APPLICATION_ID,ACTIVITY,ADMINISTERING_IC,APPLICATION_TYPE,ARRA,BUDGET_START,BUDGET_END,FOA_NUMBER,FULL_PROJECT_NUM_DC,SUBPROJECT_ID,FUNDING_ICs,FY,IC_NAME,NIH_REPORTING_CATEGORIES,ORG_CITY,ORG_COUNTRY,ORG_DEPT,ORG_DISTRICT,ORG_DUNS,ORG_FIPS,ORG_STATE,ORG_ZIPCODE,ORGANIZATION,PI_NAMEs,PI_PERSONIDS,PROJECT_NUM,PROJECT_START,PROJECT_END,PROJECT_TERMS,PROJECT_TITLE,RELEVANCE,SERIAL_NUMBER,STUDY_SECTION,STUDY_SECTION_NAME,SUFFIX,SUPPORT_YEAR,TOTAL_COST,TOTAL_COST_SUB_PROJECT
6950464,C06,RR,1,Y,02/01/2010,01/31/2015,PAR-04-122,1C06RR020547-01A1,,NCRR:3993085;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BROWNSVILLE,UNITED STATES,,27,800187965,US,TX,78520,UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL,"COLOM, LUIS VICENTE;",1877318;,1C06RR020547,02/01/2010,01/31/2015,Biomedical Research; research facility,Construction of a Biomedical Research Facility at the U*,,20547,STRB,Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities,A1,1,3993085,
7001116,C06,RR,1,Y,01/12/2010,01/11/2015,PAR-04-122,1C06RR020563-01A1,,NCRR:8000000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"COWAN, KENNETH ;",2405875;,1C06RR020563,01/12/2010,01/11/2015,"C06 Award; EXTMR; Extramural; Extramural Activities; Extramural Research Facilities Construction Project; Research Construction, Extramural; Research Facilities (Construction)",PAR04-122 Extramural Research Facilities Construction A*,,20563,STRB,Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities,A1,1,8000000,
7001751,C06,RR,1,Y,01/18/2010,01/17/2015,PAR-04-122,1C06RR020609-01A1,,NCRR:6616774;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CHARLESTON,UNITED STATES,NONE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"RAYMOND, JOHN R;",1882478;,1C06RR020609,01/18/2010,01/17/2015,EXTMR; Extramural; Extramural Activities; Programs (PT); Programs [Publication Type]; programs; research facility,Extramural Research Facilities Improvement Program: BSB*,,20609,STRB,Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities,A1,1,6616774,
7000951,C06,RR,1,Y,01/13/2010,01/12/2015,PAR-04-122,1C06RR022061-01,,NCRR:8000000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,HAMPTON,UNITED STATES,NONE,03,003135068,US,VA,23668,HAMPTON UNIVERSITY,"HARVEY, WILLIAM R;",8210481;,1C06RR022061,01/13/2010,01/12/2015,Biomedical Research; Universities,Hampton University Biomedical Research Center,,22061,STRB,Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities,,1,8000000,
7839132,C06,RR,1,Y,02/01/2010,01/31/2011,RR-09-008,1C06RR028609-01,,NCRR:5000000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BALTIMORE,UNITED STATES,NONE,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"REECE, E ALBERT;",1883551;,1C06RR028609,02/01/2010,01/31/2011,"Address; Ag element; American; Area; Arts; Award; Baltimore; C06 Mechanism; C06 Program; Cancer Center; Cancer Patient; Cancers; Cellular Stress Response; Chemotherapy-Hormones/Steroids; Department of Health and Human Services; Department of Health and Human Services (U.S.); Drug Design; EXTMR; Endocrine Gland Secretion; Equipment; Extramural; Extramural Activities; Floor; Funding; Goals; Grant; HHS; High Throughput Assay; Hormone Responsive; Hormones; Investigators; Jobs; Location; Malignant Neoplasms; Malignant Tumor; Maryland; Methods; Molecular; NCRR; NIH; National Center for Research Resources; National Institutes of Health; National Institutes of Health (U.S.); Occupations; Professional Postions; Programs (PT); Programs [Publication Type]; Recovery; Research; Research Facilities Construction Grants; Research Personnel; Researchers; Schools, Medical; Services; Silver; Structure; Therapeutic Hormone; Time; United States Department of Health and Human Services; United States Dept. of Health and Human Services; United States National Institutes of Health; Universities; anticancer research; base; cancer research; conference; design and construction; high throughput screening; interest; malignancy; medical schools; multidisciplinary; neoplasm/cancer; novel; programs; research facility; square foot; structural biology; symposium",Construction Grant 8th Floor BRB,,28609,ZRR1,Special Emphasis Panel,,1,5000000,
7839241,C06,RR,1,Y,01/26/2010,01/25/2015,RR-09-008,1C06RR028626-01,,NCRR:6651849;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,PHILADELPHIA,UNITED STATES,NONE,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"MCKENZIE, STEVEN E.;",1935335;,1C06RR028626,01/26/2010,01/25/2015,Area; Biophysics; Code; Coding System; Collaborations; Communities; Coupled; Employment; Equipment; Faculty; Floor; Grant; Housing; Information Technology; Infrastructure; Investigators; Jobs; Laboratories; Life; Modernization; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Occupations; Pharmacology; Philosophy; Physiology; Play; Principal Investigator; Productivity; Professional Postions; Recruitment Activity; Regulation; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Role; Safety; Security; Strategic Planning; Telecommunications; Therapeutic; United States National Institutes of Health; Universities; Update; Vendor; Wing; design; design and construction; designing; improved; meetings; recruit; social role; square foot,Jefferson Alumni Hall 3 West Lab Modernization,,28626,ZRR1,Special Emphasis Panel,,1,6651849,
7839524,C06,RR,1,Y,01/07/2010,01/06/2015,RR-09-008,1C06RR028634-01,,NCRR:4819500;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CINCINNATI,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"HO, SHUK-MEI ;",1872222;,1C06RR028634,01/07/2010,01/06/2015,"Age; American; Area; Atrial; Auricle of Heart; Bio-Informatics; Bioinformatics; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; C element; Caliber; Capital; Carbon; Cardiac Atrium; Communities; Computer Simulation; Computerized Models; Consumption; Diameter; Diathesis; Discipline; Disease susceptibility; Employment; Environment; Environmental Health; Environmental Health Science; Epidemiology; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Faculty; Floor; Funding; Heart Atrium; Home; Home environment; Housing; Human Resources; Interdisciplinary Research; Interdisciplinary Study; Kentucky; Life; Link; Maintenance; Maintenances; Manpower; Mathematical Model Simulation; Mathematical Models and Simulations; Mentors; Models, Computer; Multidisciplinary Collaboration; Multidisciplinary Research; Occupational Health; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; Performance; Phase; Population; Position; Positioning Attribute; Recovery; Recruitment Activity; Research; Research Training; Scientist; Simulation, Computer based; Study, Interdisciplinary; Surgical; Surgical Interventions; Surgical Procedure; Time; Toxicology; Training Programs; Translating; Translatings; Universities; Wing; Work; atrium; base; community based participatory research; comparative; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; disease/disorder proneness/risk; graduate student; human disease; improved; in silico; language translation; liability to disease; meetings; personnel; public health relevance; recruit; repair; repaired; research facility; square foot; statistics/biometry; surgery; virtual simulation",Kettering Lab Renovation to enhance PHS-supported environmental health research,,28634,ZRR1,Special Emphasis Panel,,1,4819500,
7839312,C06,RR,1,Y,01/29/2010,01/28/2011,RR-09-008,1C06RR028654-01,,NCRR:3271573;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,HARTFORD,UNITED STATES,,01,065533796,US,CT,06102,HARTFORD HOSPITAL,"SCHWARTZ, HAROLD I;",9852316;,1C06RR028654,01/29/2010,01/28/2011,"Affective Psychosis, Bipolar; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; American; Arctic; Arctic Regions; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bipolar Disorder; Boxing; Brain; Chills; Connecticut; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disabled Persons; Disabled Population; Disease; Disorder; Elevator; Emergencies; Emergency Situation; Encephalon; Encephalons; Equipment; Faculty; Fire - disasters; Fires; Generalized Growth; Goals; Growth; HOSP; Handicapped; Hospitals; Housing; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Illumination; Image; Infirmity; Institutes; Investigators; Jobs; Kanner's Syndrome; Life; Lighting; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; NMR Imaging; NMR Tomography; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Occupations; Patients; People with Disabilities; Persons with Disabilities; Postdoc; Postdoctoral Fellow; Primary Senile Degenerative Dementia; Process; Professional Postions; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Psychosis, Manic-Depressive; Pump; Research; Research Associate; Research Personnel; Researchers; Sampling; Scanning; Schizophrenia; Schizophrenic Disorders; Structure; Substance abuse problem; Technology; Testing; Tissue Growth; Universities; Work; Zeugmatography; abuse of substances; bipolar affective disorder; dementia of the Alzheimer type; dementia praecox; disabled; disabled people; disease/disorder; exhaust; handicapping; handicapping condition; heat exchanger; imaging; manic depressive disorder; manic depressive illness; neuropsychiatric; neuropsychiatry; ontogeny; post-doc; post-doctoral; primary degenerative dementia; programs; research facility; schizophrenic; senile dementia of the Alzheimer type; square foot; substance abuse",Olin Research Center: Addition for New MRI Scanner and Research Staff,,28654,ZRR1,Special Emphasis Panel,,1,3271573,
7874187,C06,RR,1,Y,01/14/2010,01/13/2015,RR-09-008,1C06RR029852-01,,NCRR:14682885;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,GAINESVILLE,UNITED STATES,OTHER HEALTH PROFESSIONS,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"PAHOR, MARCO ;",2098377;,1C06RR029852,01/14/2010,01/13/2015,"Academic Medical Centers; Address; Age; Age Group Unspecified; Aged 65 and Over; Aging; American; Area; Behavioral; Biological; CDC; Care, Health; Censuses; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Research; Clinical Study; Cognitive aging; Communities; Complex; Disabled Persons; Disabled Population; Elderly; Elderly, over 65; Environment; Epidemiology; Face; Florida; Funding; Future; Geriatric Health Services; Grant; Handicapped; Health; Health Services for the Aged; Health Services for the Elderly; Healthcare; Institutes; Intervention; Intervention Strategies; Jobs; Leadership; Life Style; Lifestyle; Memory; Modification; NIH; National Institutes of Health; National Institutes of Health (U.S.); Occupations; Older Population; People with Disabilities; Persons; Persons with Disabilities; Platinum; Platinum Black; Population; Professional Postions; Programs (PT); Programs [Publication Type]; Pt element; QOL; Quality of life; Reporting; Research; Research Resources; Resource Sharing; Resources; Senescence; Specimen Handling; Specimen Handlings; Specimen Processing; Spinal Column; Spine; Staging; Thinking; Thinking, function; Time; Training; Translational Research; Translational Research Enterprise; Translational Science; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Universities; University Medical Centers; Vertebral column; advanced age; age group; backbone; career development; conference; design; designing; disability; disabled; disabled people; elders; facial; geriatric; health services for older adults; health services for older people; health services for seniors; holistic approach; improved; innovate; innovation; innovative; interventional strategy; laboratory facility; late life; later life; novel; older adult; older person; programs; repository; research facility; response; senescent; senior citizen; success; symposium; translation research enterprise",Institute on Aging Clinical Translational Research Building,,29852,ZRR1,Special Emphasis Panel,,1,14682885,
7874377,C06,RR,1,Y,02/01/2010,01/31/2015,RR-09-008,1C06RR029858-01,,NCRR:14821565;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CORAL GABLES,UNITED STATES,NONE,20,625174149,US,FL,33134,UNIVERSITY OF MIAMI CORAL GABLES,"LEBLANC, THOMAS J;",10019521;,1C06RR029858,02/01/2010,01/31/2015,"Ag element; American; Animals; Arts; Behavior; Behavioral; Behavioral Medicine; Biological; Biological Models; Brain; Brain imaging; Brain region; Certification; Commit; Complex; Encephalon; Encephalons; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Health Psychology; Housing; Human; Human, General; Image; Image Analyses; Image Analysis; In Situ; Interdisciplinary Research; Interdisciplinary Study; Investigators; Jobs; Laboratories; Lead; Leadership; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Model System; Models, Biologic; Molecular; Multidisciplinary Collaboration; Multidisciplinary Research; NRVS-SYS; Natural regeneration; Nervous; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurosciences; Occupations; Pattern; Pb element; Professional Postions; Programs (PT); Programs [Publication Type]; Psychology, Health; ROC Analysis; Regeneration; Research; Research Personnel; Research Resources; Researchers; Resources; Science; Silver; Spinal cord damage; Study models; Study, Interdisciplinary; System; System, LOINC Axis 4; Universities; base; brain behavior; brain visualization; coral; design; designing; fMRI; frontier; heavy metal Pb; heavy metal lead; image evaluation; imaging; laboratory facility; molecular imaging; nervous system disorder; neural; neurological disease; programs; public health relevance; regenerate; relating to nervous system; square foot",Neuroscience and Health Annex on the Coral Gables Campus at the University of Mia,,29858,ZRR1,Special Emphasis Panel,,1,14821565,
7875313,C06,RR,1,Y,01/07/2010,12/31/2014,RR-09-008,1C06RR029923-01,,NCRR:10458675;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,LITTLE ROCK,UNITED STATES,NONE,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"EMANUEL, PETER D;",1862140;,1C06RR029923,01/07/2010,12/31/2014,"Area; Arkansas; Blood (Leukemia); Cancer Center; Cancer Treatment; Cancers; Clinic; Detection; Development; Electromagnetic, Laser; Epidemiology, Molecular; Faculty; Floor; Funding; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Infusion; Infusion procedures; Institutes; Jobs; Laboratory Research; Lasers; Leukemias, General; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Medical; Medicine; Molecular Epidemiology; Multiple Myeloma; Myeloma, Plasma-Cell; Occupations; Out-patients; Outpatients; Pharmacies; Pharmacogenomics; Pharmacy facility; Physicians; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Professional Postions; Profilings, Gene Expression; Radiation, Laser; Recruitment Activity; Research; Research Associate; Research, Laboratory; Science; Science of Medicine; Scientist; Speed; Speed (motion); Therapeutic; Transcript Expression Analyses; Transcript Expression Analysis; Translational Research; Translational Research Enterprise; Translational Science; Translations; Tumor Cell; Universities; anticancer therapy; base; cancer therapy; clinical care; design; designing; innovate; innovation; innovative; leukemia; malignancy; myeloma; myelomatosis; neoplasm/cancer; neoplastic cell; novel; post-doc; post-doctoral; recruit; square foot; translation research enterprise",Construction completion of the Cancer Institute's shelled space on floors 9 and 1,,29923,ZRR1,Special Emphasis Panel,,1,10458675,
7877590,C06,RR,1,Y,01/13/2010,01/12/2015,RR-09-008,1C06RR030115-01,,NCRR:15000000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CAMBRIDGE,UNITED STATES,VETERINARY SCIENCES,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"FOX, JAMES G;",1881890;,1C06RR030115,01/13/2010,01/12/2015,"Accreditation; Animals; Animals, Laboratory; Beds; Biomedical Research; Caring; EXTMR; Ensure; Environment; Extramural; Extramural Activities; Funding; Goals; House mice; Housing; Human Resources; Institutes; Laboratory Animals; Mammals, Mice; Mammals, Rodents; Manpower; Mice; Mission; Murine; Mus; Mus musculus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Operation; Operative Procedures; Operative Surgical Procedures; Programs (PT); Programs [Publication Type]; Quarantine; Research Resources; Resources; Rodent; Rodentia; Rodentias; Source; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; United States National Institutes of Health; Vacuum; animal facility; animal resource; base; high standard; isolation/quarantine; pathogen; personnel; programs; research facility; surgery",Extramural Research Facilities Improvement Program,,30115,ZRR1,Special Emphasis Panel,,1,15000000,
7898499,C06,RR,1,Y,01/28/2010,01/27/2015,RR-09-008,1C06RR030610-01,,NCRR:6530203;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,PHOENIX,UNITED STATES,,04,788240674,US,AZ,85006,BANNER ALZHEIMER'S INSTITUTE,"REIMAN, ERIC M;",2096044;,1C06RR030610,01/28/2010,01/27/2015,"20 year old; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Arizona; Biomedical Research; Brain imaging; Cancer Center; Cancer, Oncology; Clinical Trials; Clinical Trials, Unspecified; Communication; Cyclotrons; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Development; Development and Research; Devices; Diabetes Mellitus; Disease; Disorder; Environment; Equipment; Evaluation; Funding; Future; General Population; General Public; Generalized Growth; Growth; HOSP; Health; Hospitals; Image; Image Analyses; Image Analysis; Imaging Device; Imaging Procedures; Imaging Techniques; Imaging Tool; Institutes; Institution; Investigators; Investments; Jobs; Laboratories; Lead; Leadership; Longitudinal Studies; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Methods; NIH RFA; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Obesity; Occupations; PET; PET Scan; PET imaging; PETSCAN; PETT; Participant; Pb element; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Senile Degenerative Dementia; Productivity; Professional Postions; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Quality Control; R & D; R&D; ROC Analysis; Rad.-PET; Radiation Chemistry; Radioactive; Radiochemistry; Request for Applications; Research; Research Institute; Research Personnel; Research Resources; Researchers; Resources; Role; SCHED; Safety; Schedule; Security Measures; System; System, LOINC Axis 4; Tag; Technics, Imaging; Technology; The Sun; Tissue Growth; Tracer; Universities; Zeugmatography; adiposity; age dependent; age related; base; brain visualization; catalyst; clinical investigation; corpulence; corpulency; corpulentia; dementia of the Alzheimer type; design; designing; diabetes; disease/disorder; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; image evaluation; imaging; improved; long-term study; meetings; normal aging; novel; obese; obese people; obese person; obese population; oncology; ontogeny; primary degenerative dementia; programs; research and development; research study; senile dementia of the Alzheimer type; social role; square foot; twenty year old","Cyclotron, PET and MRI Facility Improvement: A Scientific Resource for Arizona",,30610,ZRR1,Special Emphasis Panel,,1,6530203,
7801860,F30,HL,1,,01/21/2010,01/20/2011,PA-08-021,1F30HL099024-01,,NHLBI:38709;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,EAST LANSING,UNITED STATES,PHARMACOLOGY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"DAVIS, ROBERT PATRICK;",9799880;,1F30HL099024,01/21/2010,07/20/2013,"11-Decorticosterone; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 21-Hydroxy-4-pregnene-3,20-dione; 21-Hydroxyprogesterone; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT Receptors; 5-Hydroxytryptamine; 5-Hydroxytryptamine Receptors; 5HT; 5HT transporter; 5HTT protein; Abbreviations; Acetates; Acetylcholine; Afferent Neurons; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Arteries; Bizzozero's corpuscle/cell; Blood Plasma; Blood Platelets; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; Blood Vessels; CGRP; Calcitonin Gene-Related Peptide; Cardiac Diseases; Cardiac Disorders; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Common Rat Strains; Control Animal; Cortexone; Deetjeen's body; Deoxycorticosterone; Desoxycorticosterone; Desoxycortone; EC 1.14.13.39; EDRF Synthase; ESRD; End stage renal failure; End-Stage Kidney Disease; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enteramine; Essential Hypertension; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Goals; Guanylyl Cyclase-Activating Factor Synthase; Hayem's elementary corpuscle; Heart Diseases; Hippophaine; Human; Human, General; Hypertension; Hypotension; In Vitro; Inbred SHR Rats; Infusion; Infusion procedures; Investigators; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow platelet; Measures; Mediating; Methods and Techniques; Methods, Other; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NADPH-Diaphorase; NO Synthase; Nerve; Nervous; Nervous System, CNS; Neuraxis; Neurons, Afferent; Neurons, Sensory; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; Pb element; Peripheral Resistance; Plasma; Platelets; Play; Pregn-4-ene-3,20-dione, 21-hydroxy-; Pressure; Pressure- physical agent; Process; Rat; Rats, Inbred SHR; Rats, SHR; Rats, Spontaneously Hypertensive; Rattus; Receptor Protein; Relaxation; Renal Disease, End-Stage; Research; Research Personnel; Researchers; Resistance, Total Peripheral; Reticuloendothelial System, Platelets; Reticuloendothelial System, Serum, Plasma; Risk Factors; Role; SNS; Sensory; Sensory Cell Afferent Neuron; Serotonin; Serum, Plasma; Sodium Chloride; Sodium chloride (NaCl); Solutions; Stroke; Sympathetic Nervous System; System; System, LOINC Axis 4; Techniques; Testing; Thrombocytes; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vascular Resistance, Systemic; Vascular, Heart; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasorelaxation; afferent nerve; brain attack; cerebral vascular accident; circulatory system; endothelial cell derived relaxing factor; falls; heart disorder; heavy metal Pb; heavy metal lead; hemodynamics; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; in vivo; inhibitor; inhibitor/antagonist; male; model organism; new therapeutic target; normotensive; pressure; primary hypertension; protective effect; receptor; response; reuptake; salt; sensory nerve; serotonin receptor; serotonin transporter; social role; sodium-dependent serotonin transporter; spontaneous hypertensive rat; stroke; thrombocyte/platelet; vascular",Mechanisms of 5-hydroxytryptamine-induced hypotension,,99024,ZRG1,Special Emphasis Panel,,1,38709,
7805974,F30,HL,1,,01/12/2010,01/11/2011,PA-08-021,1F30HL099028-01,,NHLBI:32753;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"CHOW, ANDREW ;",8780398;,1F30HL099028,01/12/2010,08/12/2012,"21+ years old; AMD-3100; AMD3100; ASPR; Ablation; Adrenergic Receptor; Adrenoceptors; Adult; Animals; Antibodies; Antibodies, Blocking; Aspirate; Aspirate substance; Assay; Bioassay; Biologic Assays; Biological Assay; Blocking Antibodies; Blood Diseases; Blood Precursor Cell; Blood monocyte; Blood, Cord; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cell Transplantation; Bone Marrow Cells; Bone Marrow Transplant; Bone Marrow Transplantation; Burn injury; Burns; CD114 Antigen; CD115; CD115 Antigens; CD115 Gene; CSF-1-R; CSF1R; CSF1R Gene Product; CSF1R gene; CSFMR; CXCL12; CXCL12 gene; Cancers; Cardiac infarction; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Transplants; CellLine; Cells; Co-culture; Cocultivation; Coculture; Coculture Techniques; Colony Stimulating Factor 1 Receptor; Colony Stimulating Factor 1 Receptor Gene; Colony Stimulating Factor 3; Colony Stimulating Factor 3 Receptor; Cytofluorometry, Flow; Cytokines, Chemotactic; Data; Dependence; Development; Dichloromethylene Diphosphonate; Diphosphonate, Dichloromethylene; ELISA; Engraftment; Enzyme-Linked Immunosorbent Assay; Erythropoiesis; Extracellular Fluid; FDA approved; Fibroblast Intermediate Filament Proteins; Filgrastim; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; G-CSF Receptors; G-CSF Recombinant, Human Methionyl; GCSF Receptor; Genes; Genetic; Genetic Models; Grafting, Bone Marrow; Granulocyte Colony-Stimulating Factor; Granulocyte Colony-Stimulating Factor Receptors; Harvest; Hematinics; Hematologic Diseases; Hematological Disease; Hematological Disorder; Hematopoiesis; Hematopoietic; Hematopoietic Agents; Hematopoietic Cellular Control Mechanisms; Hematopoietic Stem Cell Mobilization; Hematopoietic stem cells; High Dose Chemotherapy; Homologous Chemotactic Cytokines; Human, Adult; IFP; Injury; Intercrines; Intermediate Filament Proteins; Intracellular Communication and Signaling; Island; LPS; Lead; Lipopolysaccharides; Liposomal; Liposomes; Literature; Macrophage Colony Stimulating Factor I Receptor; Macrophage Colony-Stimulating Factor Receptor; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Transplantation; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Microfluorometry, Flow; Moab, Clinical Treatment; Models, Genetic; Monoclonal Antibodies; Mother Cells; Murine; Mus; Myocardial Infarct; Myocardial Infarction; Nerve Degeneration; Nervous; Neupogen; Neuron Degeneration; Operation; Operative Procedures; Operative Surgical Procedures; PBSF; Patients; Pb element; Pluripoietin; Population; Production; Progenitor Cells; Progenitor Cells, Hematopoietic; Protein Array; Proto-Oncogene Protein fms; Receptor, CSF-1; Receptors, Epinephrine; Receptors, M-CSF; Recombinant-Methionyl Human Granulocyte Colony-Stimulating Factor; Regulation; Relative; Relative (related person); Reporting; Reticuloendothelial System, Bone Marrow; Retrieval; Role; SCYB12; SDF-1A; SDF-1B; SDF1; SDF1A; SDF1B; SIS cytokines; SNS; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stem Cell Mobilization; Stem cells; Stromal Cells; Surgical; Surgical Interventions; Surgical Models; Surgical Procedure; Sympathectomy; Sympathetic Denervation; Sympathetic Nervous System; TLSF-A; TLSF-B; TPAR1; Testing; Transgenic Mice; Transplantation; Transplantation, Bone Marrow Cell; Transplants, Cell; Umbilical Cord Blood; Wound Healing; Wound Repair; adenoreceptor; adult human (21+); biological signal transduction; blood disorder; c-FMS; c-fms Protein; cardiac infarct; chemoattractant cytokine; chemokine; clinical relevance; clinically relevant; clodronate; coronary attack; coronary infarct; coronary infarction; cultured cell line; cytokine; experiment; experimental research; experimental study; fetal cord blood; filgrastrim; flow cytophotometry; granulocyte colony stimulating factor; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; improved; in vivo; in vivo Model; macrophage; malignancy; monocyte; mouse model; neoplasm/cancer; nestin; nestin protein; neural; neural degeneration; neurodegeneration; neuronal degeneration; peripheral blood; public health relevance; r-metHuG-CSF; reconstitute; reconstitution; relating to nervous system; research study; social role; stem; stem cell niche; surgery; tissue repair; transplant",Maintenance of the Hematopoietic Stem Cell Niche Monocytes and Macrophages,,99028,ZRG1,Special Emphasis Panel,,1,32753,
7800097,F30,HL,1,,01/11/2010,01/10/2011,PA-05-151,1F30HL099036-01,,NHLBI:36120;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","VAUBEL, RACHAEL ;",9831153;,1F30HL099036,01/11/2010,11/10/2012,"1,2-dithiolane-3-valeramide; 2-Keto-4-Hydroxyglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase Complex; 2-Oxoglutarate[{..}]lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating); 6,8-thioctic amide; Active Oxygen; Affect; Body Tissues; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiomyopathy, Hypertrophic Obstructive; Cell model; Cellular model; Chaperone; Cleaved cell; Consumption; Crystallographies; Crystallography; Dehydrogenases; Diaphorase (Lipoamide Dehydrogenase); Dihydrolipoamide[{..}] NAD+ oxidoreductase; Dihydrolipoyl Dehydrogenase; Energy Expenditure; Energy Metabolism; Enzymes; Equilibrium; Esteroproteases; Fe element; Generations; Genetic Alteration; Genetic Change; Genetic defect; Heart; Heart Diseases; Human; Human, General; Hypertrophic Cardiomyopathy; In Vitro; Iron; Ketoglutarate Dehydrogenase Complex; Knowledge; Lead; Lipoamide Dehydrogenase; Lipoic Acid Dehydrogenase; Lipoyl Dehydrogenase; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Diseases; Metabolic Disorder; Mitochondria; Molecular Chaperones; Mutation; NAD Diaphorase; NADH; NADH Diaphorase; Natural regeneration; Oxidative Stress; Oxidoreductase; Oxoglutarate Dehydrogenase; Oxygen Radicals; Pathogenesis; Pb element; Peptidases; Peptide Hydrolases; Play; Pro-Oxidants; Production; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Pyruvate; Pyruvates; Reactive Oxygen Species; Reductases; Regeneration; Research; Role; Testing; Thesaurismosis; Tissues; Yeasts; alpha-Ketoglutarate Dehydrogenase; alpha-Ketoglutarate Dehydrogenase Complex; alpha-lipoic amide; balance; balance function; base; cleaved; cofactor; diaphorase; dihydrolipoamide dehydrogenase; dimer; enzyme activity; frataxin; gene product; genome mutation; heart disorder; heavy metal Pb; heavy metal lead; hypertrophic myocardiopathy; improved; in vivo; infancy; infantile; lipamide; lipoamide; metabolism disorder; mitochondrial; oxidative damage; prevent; preventing; regenerate; social role",Role of DLD in oxidative stress-induced cardiac disease,,99036,ZRG1,Special Emphasis Panel,,1,36120,
7803292,F30,NS,1,,02/01/2010,01/31/2011,PA-05-151,1F30NS065566-01A1,,NINDS:32356;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"FARMER, JOCELYN R;",8404917;,1F30NS065566,02/01/2010,01/31/2012,"0-11 years old; 21+ years old; Adult; Age; Antiviral Agents; Antiviral Drugs; Antivirals; Arboviral infections; Arbovirus Infections; Arboviruses; Arthropod-Born Viral Infection; Arthropod-Borne Viruses; Brain; Cells; Central Nervous System; Child; Child Youth; Childhood; Children (0-21); Clinical; Data; Defect; Development; Disease; Disease Outbreaks; Disorder; Encephalitis; Encephalitis Virus, Western Equine; Encephalitis, Viral; Encephalomyelitis Virus, Western Equine; Encephalon; Encephalons; Goals; Human; Human, Adult; Human, Child; Human, General; IFN; IRF-9; ISGF3 gamma subunit; ISGF3-gamma; ISGF3-gamma protein; ISGF3G protein; Immune; Immune Function, Cellular; Immune response; In Vitro; Infection; Infectious Encephalomyelitis, Viral; Inflammation, Brain; Interferon Type I; Interferons; Knock-out; Knockout; Laboratories; Lead; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Molecular; Morbidity; Morbidity - disease rate; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurocyte; Neurologic; Neurological; Neurons; Outbreaks; Pathway interactions; Patients; Pb element; Peripheral; Population; Predisposition; Production; Public Health; Receptor Protein; Role; Severities; Severity of illness; Signal Pathway; Site; Susceptibility; Testing; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral; Viral Burden; Viral Diseases; Viral Encephalitis; Viral Load; Viral Load result; Virus Diseases; Virus Replication; WEE Virus; Western Equine Encephalitis Virus; Work; adult human (21+); age dependent; age related; children; disease severity; disease/disorder; farmer; gain of function; hESC; heavy metal Pb; heavy metal lead; host response; human ES cell; human ESC; human embryonic stem cell; immune function; immunoresponse; in vivo; interferon regulatory factor-9; interferon-stimulated gene factor 3, gamma subunit; mouse model; neuronal; neurotropic; neurovirulence; novel; p48 ISGF3gamma; p48 ISRE-binding protein; pathway; pediatric; public health medicine (field); receptor; response; social role; viral infection; virus infection; virus multiplication; youngster",The role of neuronal maturation on antiviral type I interferon pathway activity.,,65566,ZNS1,Special Emphasis Panel,A1,1,32356,
7803996,F30,NS,1,,04/01/2010,03/31/2011,PA-05-151,1F30NS067731-01,,NINDS:46380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,NEUROSURGERY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SHIN, SAMUEL ;",8955124;,1F30NS067731,04/01/2010,03/31/2015,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Accounting; Acute; Affect; Aldehydes; Amino Acids; Attenuated; Autoregulation; Behavioral; Blotting, Western; Body Tissues; Brain; Carboxy-Lyases; Cause of Death; Cell/Tissue, Immunohistochemistry; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chronic; Cognitive deficits; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Critiques; DA Neuron; DAT; DAT dopamine transporter; Decarboxylases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disinhibition; Dopamine; Dopamine Agonists; Dopamine Receptor Agonists; Dopamine neuron; Dopaminergic Agonists; Dysfunction; Encephalon; Encephalons; Enzymes; Functional disorder; Future; H2O2; HPLC; High Pressure Liquid Chromatography; Homeostasis; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hydroxytyramine; Hypothalamic structure; Hypothalamus; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Incidence; Individual; Injury; Intermediary Metabolism; Knock-out; Knockout; Knockout Mice; L-Tyrosine,tetrahydrobiopterin[{..}]oxygen oxidoreductase (3-hydroxylating); Lead; Link; Literature; MAO Inhibitors; MAOI; METBL; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Microdialysis; Monoamine Oxidase Inhibitors; Murine; Mus; NAC precursor; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuronal Transmission; Neurons; Neurotransmitters; Null Mouse; Outcome; Oxidative Stress; PARK1 protein; PARK4 protein; Pathologic; Pathology; Pb element; Permeability; Physiological Homeostasis; Physiopathology; Proteins; Rat; Rattus; Regulation; Risk; Role; SNCA; SNCA protein; Striate Body; Striatum; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Agents; Time; Tissues; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Tyrosine 3-Monooxygenase; Tyrosine Hydroxylase; Tyrosine Hydroxylase Inhibitor; United States; Update; VESCL; Vesicle; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; alpha synuclein; alphaSP22; aminoacid; base; behavioral disinhibition; brain tissue; cognitive function; disability; dopamine transporter; dopamine transporter proteins; dopaminergic neuron; enzyme activity; experiment; experimental research; experimental study; frontal cortex; frontal lobe; gene product; heavy metal Pb; heavy metal lead; hypothalamic; improved; in vivo; insight; meetings; neurodegenerative illness; neuronal; neurotoxic; neurotransmission; non A-beta component of AD amyloid; non A4 component of amyloid precursor; pathophysiology; prevent; preventing; protein blotting; research study; reuptake; social role; striatal; synuclein; therapeutic development; traumatic brain damage; uptake",The Effects of Traumatic Brain Injury in Alpha Synuclein and Dopamine Regulation,,67731,NST,Training Grant and Career Development Review Committee,,1,46380,
7810398,F30,NS,1,,02/01/2010,01/31/2011,PA-05-151,1F30NS068108-01,,NINDS:28794;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MADISON,UNITED STATES,PHARMACOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HANSON, KEITH A;",8743784;,1F30NS068108,02/01/2010,08/31/2013,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; ALS; APF-1; ATP-Dependent Proteolysis Factor 1; Address; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyotrophic Lateral Sclerosis; Assay; Autophagocytosis; Autophagosome; Autoregulation; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cells; Critiques; Cytoplasm; Cytoplasmic Inclusion; DNA-Binding Proteins; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Drosophila; Drosophila genus; Drosophila melanogaster; Drugs; Familial Amyotrophic Lateral Sclerosis; Flies; Frontotemporal Lobar Degenerations; Fruit Fly, Drosophila; Future; Gehrig's Disease; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic Techniques; Genetic defect; Goals; HMG-20; High Mobility Protein 20; Homeostasis; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Individual; Isoforms; Lead; Lewy Body Parkinson Disease; Lobar Degenerations, Frontotemporal; Lou Gehrig Disease; Macropain; Macroxyproteinase; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Medication; Methods and Techniques; Methods, Other; Microscopic; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motor Cell; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Multicatalytic Proteinase; Mutation; Nerve Cells; Nerve Degeneration; Nerve Tissue; Nerve Unit; Nervous Tissue; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Nuclear; Outcome; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathologic; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Physiological Homeostasis; Play; Point Mutation; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Isoforms; Proteins; Proteosome; Research; Role; Structure; TDP-43; Tars; Technics, Genetic; Techniques; Testing; Toxic effect; Toxicities; Transgenic Organisms; Ubiquitin; Update; Visual Receptor; aberrant protein folding; abnormal protein folding; autophagy; base; cost; dementia of the Alzheimer type; disease/disorder; drug/agent; fly; fruit fly; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; insight; insoluble aggregate; meetings; motoneuron; multicatalytic endopeptidase complex; mutant; neural degeneration; neurodegeneration; neurodegenerative illness; neuron toxicity; neuronal; neuronal degeneration; neuronal toxicity; neurotoxicity; novel; nucleic acid binding protein; overexpression; pathologic protein folding; pathway; primary degenerative dementia; protein TDP-43; protein aggregate; protein mis-folding; protein misfolding; public health relevance; response; senile dementia of the Alzheimer type; social role; socioeconomic; socioeconomically; socioeconomics; transgenic; ubiquilin",ALS-associated TDP-43 Aggregation: A Drosophila Model and A Role for Autophagy,,68108,NST,Training Grant and Career Development Review Committee,,1,28794,
7911575,F31,AT,1,,02/15/2010,02/14/2011,PA-09-208,1F31AT005386-01A1,,NCCAM:34195;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,NEW BRUNSWICK,UNITED STATES,MISCELLANEOUS,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"GRAZIOSE, ROCKY T;",9715713;,1F31AT005386,02/15/2010,02/14/2014,"1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-; 2nd World War; Active Follow-up; Animal Model; Animal Models and Related Studies; Animals; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Artemisinins; Arts; Aves; Avian; Biochemical; Birds; Blood erythrocyte; Blood normocyte; Botanicals; Cessation of life; Chemicals; Chlorochin; Chloroquine; Data; Death; Development; Drug resistance; Drugs; Erythrocytes; Erythrocytic; Future; Investigation; Khingamin; Malaria; Mammals, Mice; Marrow erythrocyte; Medication; Methods and Techniques; Methods, Other; Mice; Modeling; Murine; Mus; Paludism; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Physiologic; Physiological; Plant Extracts; Plants; Plants, General; Plasmodium; Plasmodium Infections; Plasmodium berghei; Plasmodium falciparum; Programs (PT); Programs [Publication Type]; Public Health; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reporting; Research; Research Proposals; Reticuloendothelial System, Erythrocytes; Scientist; Screening procedure; Second World War; Source; Techniques; Testing; Toxic effect; Toxicities; Work; World War II; World War, 1939-1945; arteannuin; artemisinin; artemisinine; blood corpuscles; drug resistant; drug/agent; efficacy evaluation; fight against; follow-up; in vitro Assay; in vitro activity; in vivo; model organism; neglect; novel; pre-clinical; preclinical; programs; public health medicine (field); public health relevance; qinghaosu; quing hau sau; quinghaosu; resistance to Drug; resistant to Drug; rodent plasmodia; screening; screenings",Efficacy evaluation of traditionally used antimalarial plants," 7. Project Narrative      The relevance of this research proposal to public health is to support the traditional use of plants  used to treat malaria, provide crucial preclinical data for the future development of novel antimalarial  therapies, and help to elucidate novel biochemical and physiological information about plasmodium- host interactions. By evaluating botanical treatments that might be cultivated locally, used locally, and  have local benefits, this scientific work will have broad and long-term impacts both on the global scale as  well on the communal scale in the fight against malaria. ",5386,ZAT1,Special Emphasis Panel,A1,1,34195,
7808230,F31,DA,1,,02/01/2010,01/31/2011,PA-07-002,1F31DA024934-01A2,,NIDA:30316;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MADISON,UNITED STATES,PSYCHIATRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"FRIEDMAN, EUGENIA LYNN;",9181957;,1F31DA024934,02/01/2010,01/31/2012,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ATP-protein phosphotransferase; Addiction, Cocaine; Addiction, Drug; Affect; Alcohols; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Area; Arm; Associative Learning; Attenuated; Behavior; Behavioral; Biochemical Pathway; Biochemistry; Biological; Brain region; Cell/Tissue, Immunohistochemistry; Chemical Class, Alcohol; Chemical Dependence; Chemistry, Biological; Clinical; Cocaine; Cocaine Dependences; Cocaine Users; Common Rat Strains; Conditioned Stimulus; Conditioning, Classical; Conditionings, Classical; Control Groups; Cornu Ammonis; Cues; Data; Dependence, Drug; Dependences, Cocaine; Dose; Drug Addiction; Drug Dependency; Drug usage; Drugs; Event; Fear; Fright; Genetics, in situ Hybridization; Goals; Harvest; Hippocampus; Hippocampus (Brain); Hour; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Infusion; Infusion procedures; Intervention; Intervention Strategies; Kinase M, Protein; Lateral; Learning; Long-Term Potentiation; Maintenance; Maintenances; Mammals, Rats; Measures; Mediating; Medical; Medication; Memory; Messenger RNA; Metabolic Networks; Methods; Molecular; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Pavlovian conditioning; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Positive Reinforcer; Process; Protein Kinase; Protein Kinase M; Proteins; Protocol; Protocols documentation; Public Health; RNA, Messenger; Rat; Rattus; Relapse; Rewards; Role; Running; SCHED; Schedule; Self Administration; Site; Stimulus; Substance of Abuse; Tactile; Testing; Time; Training; United States; Upper arm; Users, Cocaine; Visual; Work; addiction; amygdaloid nuclear complex; base; brain tissue; classical conditioning; conditioned fear; conditioning; craving; design; designing; drug craving; drug reward; drug seeking behavior; drug use; drug/agent; experience; experiment; experimental research; experimental study; fear conditioning; gene product; glycogen synthase a kinase; hippocampal; hydroxyalkyl protein kinase; in situ Hybridization Staining Method; inhibitor; inhibitor/antagonist; interventional strategy; long term memory; mRNA; neuronal; phosphorylase b kinase kinase; preference; protein expression; public health medicine (field); research study; response; social role; substances of abuse",PKM zeta-dependent maintenance of LTM in cocaine conditioned place preference,,24934,ZRG1,Special Emphasis Panel,A2,1,30316,
7807615,F31,DA,1,,02/01/2010,01/31/2011,PA-07-002,1F31DA028133-01,,NIDA:34980;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,DURHAM,UNITED STATES,BIOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"HEILBRONNER, SARAH RACHEL;",9853532;,1F31DA028133,02/01/2010,01/31/2013,"3(2H)-Isoxazolone, 5-(aminomethyl)-; Accounting; Address; Agarin; Anterior; Area; Behavior; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Complex; Data; Decision Making; Disease; Disorder; Drug abuser; Encephalon; Encephalons; FLR; Failure (biologic function); Family; Friends; GABA Agonists; GABA Receptor Agonists; Health; Housing; Individual; Intracellular Communication and Signaling; Jobs; Left; Light; Literature; Mediating; Metric; Misuses drugs; Monkeys; Muscimol; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Occupations; Outcome; Pantherine; Pattern; Photoradiation; Play; Problem Solving; Problem drug user; Process; Professional Postions; Property; Property, LOINC Axis 2; Reinforcement, Social; Relative; Relative (related person); Research; Rewards; Risk; Role; Signal Transduction; Signal Transduction Systems; Signaling; Social Reinforcement; Source; Stealing; Stealings; Substance abuse problem; System; System, LOINC Axis 4; Testing; Theft; Time; Uncertainty; abstracting; abuse of substances; abused drugs; addiction; base; biological signal transduction; cingulate cortex; discounting; disease/disorder; doubt; drug of abuse; drugs abused; drugs of abuse; experiment; experimental research; experimental study; failure; gamma-Aminobutyric Acid Agonists; neural mechanism; neuromechanism; neuronal; preference; research study; response; reward processing; social; social role; substance abuse",The role of cingulate cortex in reward-based decision making,,28133,ZRG1,Special Emphasis Panel,,1,34980,
7812802,F31,DA,1,,02/25/2010,02/24/2011,PA-07-106,1F31DA028333-01,,NIDA:37980;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"BOOKER, LAMONT ;",9817143;,1F31DA028333,02/25/2010,07/24/2012,"2-arachidonoyl-glycerol; 2-arachidonoylglycerol; 2-arachidonyl-glycerol; 2-arachidonylglycerol; 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-; 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)-; 5,8,11,14-eicosatetraenoylethanolamide; Absence of pain sensation; Absence of sensibility to pain; Address; Agonist; American; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animals, Genetically Modified; Anodynes; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antinociceptive Agents; Antinociceptive Drugs; Area; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Attention; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior; Binding; Binding (Molecular Function); Bradykinin; CB2 Receptor; Cannabinoids; Cannabinoids, Endogenous; Carrageenan; Carrageenin; Cell Communication and Signaling; Cell Signaling; Cell Wall; Cells; Central Nervous System; Cytokines, Chemotactic; Development; Differentiation Factor, B-Cell; Diffuse Myofascial Pain Syndrome; Dinoprostone; Disease; Disorder; Dropsy; Drugs; ELISA; Edema; Endocannabinoids; Endotoxins; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Enzymes; Euler-Gaddum Substance P; FAAH protein; Feels no pain; Fibromyalgia; Fibromyositis-Fibromyalgia Syndrome; Fibrositis; Filament; Freund's Adjuvant; Freund's Complete Adjuvant; GMO Animals; Genetically Modified Animals; Glycerol Monoester Hydrolases; Glycerol-ester acylhydrolase; Goals; Gram-Negative Bacteria; HPGF; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; Hybridoma Growth Factor; Hydrops; Hyperalgesia; Hyperalgesic Sensations; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Immune; Immunostimulants, adjuvants, Freund's; Inflammation; Inflammatory; Inflammatory Response; Injection of therapeutic agent; Injections; Intercrines; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Knockout Mice; LPS; Life; Life Style; Lifestyle; Lipopolysaccharides; Locomotor Activity; MGI-2; MPD syndrome; Mammals, Mice; Marihuana; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular Interaction; Monoacylglycerol Lipases; Monoglyceride Esterases; Monoglyceride Hydrolase; Monoglyceride Lipases; Motor Activity; Murine; Mus; Myeloid Differentiation-Inducing Protein; N arachidonoyl 2 hydroxyethylamide; N-(2-hydroxyethyl)arachidonamide; Nervous System, CNS; Neuraxis; Neuropathy; No sensitivity to pain; Nociception; Nociceptors; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; PGE2; PGE2 alpha; PGE2alpha; Pain; Painful; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmacytoma Growth Factor; Play; Post-Operative; Postherpetic neuralgia; Postoperative; Postoperative Period; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Proteins; Receptor Protein; Receptor, Cannabinoid, CB2; Rheumatism, Muscular; Role; SIS cytokines; SP(1-11); Signal Transduction; Signal Transduction Systems; Signaling; Societies; Stimulus; Substance P; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Tail; Techniques; Technology; Testing; Therapeutic; Time; Wild Type Mouse; allodynia; analgesia; anandamide; anandamide (20.4,n-6); arachidonoyl ethanolamide; arachidonoylethanolamide; arachidonylethanolamide; biological signal transduction; biological systems; cannabinoid receptor; chemoattractant cytokine; chemokine; combat; cytokine; disease/disorder; drug/agent; fatty acid amide hydrolase; fibromyalgia syndrome; gene product; hyperalgia; in vivo; inflammatory pain; inhibitor; inhibitor/antagonist; interferon beta 2; kallidin 9; kallidin I; mechanical allodynia; myofascial pain dysfunction syndrome; neurokinin 1; neuropathic; nociceptive; oleamide hydrolase; post herpetic neuralgia; receptor; response; social role; surgery; tool",Determining the Role of FAAH and MAGL in the Modulation of Mechanical Allodynia,,28333,ZRG1,Special Emphasis Panel,,1,37980,
7808235,F31,DA,1,,04/01/2010,03/31/2011,PA-07-002,1F31DA028812-01,,NIDA:31840;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,PSYCHOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"GROMAN, STEPHANIE MARY;",9839007;,1F31DA028812,04/01/2010,03/31/2013,"2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Affinity; Agonist; Behavior; Behavioral; Binding; Binding (Molecular Function); Blinking; Brain; Brain region; Caudate Nucleus; Caudate nucleus structure; Cerebrum; Cognition; Cognitive; Corpus Striatum; Corpus striatum structure; D-arabino-Hexose, 2-deoxy-; D2 receptor; DRD2; DRD2 Receptor; Decision Making; Deoxyglucose; Dependence; Dependence, Substance; Development; Disease; Disorder; Dopamine; Dopamine Agonists; Dopamine D2 Receptor; Dopamine Receptor Agonists; Dopaminergic Agonists; Dose; Drug abuse; Drugs; Economics; Encephalon; Encephalons; Exhibits; Family; Hand; Hydroxytyramine; Imaging Procedures; Imaging Techniques; Impulsivity; Individual; Individual Differences; Intake; Investigation; Laboratories; Lead; Left; Link; Measurement; Measures; Mediating; Medical Imaging, Positron Emission Tomography; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods and Techniques; Methods, Other; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monkeys; Nervous; Nervous System, Brain; Nucleus Caudatus; PET; PET Scan; PET imaging; PETSCAN; PETT; Patient Self-Report; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Population; Positron Emission Tomography Scan; Positron-Emission Tomography; Prevention; Process; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Receptor Protein; Risk; Role; Self-Report; Short-Term Memory; Societies; Striate Body; Striatum; Substance Addiction; Substance abuse problem; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Temperament; Variant; Variation; abuse of drugs; abuse of substances; abuses drugs; base; behavior measurement; behavioral measure; behavioral measurement; biobehavior; biobehavioral; biological systems; caudate nucleus; cognitive control; conformation; conformational state; disease/disorder; dopamine system; drug/agent; experiment; experimental research; experimental study; eye blink; eyeblink; flexibility; functional outcomes; glucose metabolism; heavy metal Pb; heavy metal lead; in vivo; insight; neural; neural mechanism; neuroimaging; neuromechanism; non-human primate; nonhuman primate; pre-clinical research; preclinical research; radioligand; receptor; receptor expression; receptor function; relating to nervous system; research study; response; social; social role; striatal; substance abuse; trait; treatment strategy; working memory",Impulsivity and D2 Receptor Function: Behavioral and PET Correlates,,28812,ZRG1,Special Emphasis Panel,,1,31840,
7911102,F31,DC,1,,04/01/2010,03/31/2011,PA-09-208,1F31DC010960-01,,NIDCD:29507;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,UNIVERSITY PARK,UNITED STATES,PSYCHOLOGY,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"POLL, GERARD HUMPHREY;",10021058;,1F31DC010960,04/01/2010,03/31/2013,"0-11 years old; 21+ years old; Accuracy of Diagnosis; Adult; Affect; Child; Child Youth; Children (0-21); Clinical Evaluation; Clinical Testing; Comprehension; Diagnosis; Diagnostic; Effectiveness; Human, Adult; Human, Child; Individual; Language; Language Disorders; Language disability; Measures; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Nature; Participant; Performance; Phrases (PT); Phrases [Publication Type]; Play; Process; Programs (PT); Programs [Publication Type]; Records; Research; Role; Short-Term Memory; Social Well-Being; System; System, LOINC Axis 4; To specify; adult human (21+); adult youth; children; clinical test; diagnostic accuracy; kindergarten; language deficit; language processing; lexical; peer; phrases; processing speed; programs; public health relevance; research clinical testing; social role; specific language impairment; syntactic; syntax; theories; tool; working memory; young adult; youngster",Sentence processing factors in specific language impairment (SLI)," Project Narrative Specific language impairment (SLI) affects more than 7% of children in kindergarten and the condition persists into adulthood in over 70% of cases, with significant consequences for the educational, vocational and social well being of affected individuals. Sentence imitation performance is one of the most effective and widely used means of identifying individuals with SLI, but little is known about why it is so effective. This project aims to identify specific factors that may explain the poor sentence imitation performance of adults with SLI, indicating how the task can be refined for better diagnostic accuracy and clarifying what poor sentence imitation reveals about the nature of SLI.",10960,CDRC,Communication Disorders Review Committee,,1,29507,
7804911,F31,DE,1,,01/15/2010,01/14/2013,PA-07-002,1F31DE019749-01A1,,NIDCR:42180;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,PITTSBURGH,UNITED STATES,GENETICS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"WALD, ABIGAIL ;",9224564;,1F31DE019749,01/15/2010,01/14/2013,"Affect; Alcohol Drinking; Alcohol consumption; Alcohols; Basal lamina; Benign Verrucous Lesion; Buccal Mucosa; Cancer Genes; Cancer Induction; Cancer-Promoting Gene; Cancerous; Cancers; Carcinoma of the Oropharynx; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Line; Cell Lines, Strains; CellLine; Chemical Class, Alcohol; Common wart; Computer Analysis; DNA; Data; Deoxyribonucleic Acid; Detection; Development; Diagnostic; EtOH drinking; Expression Profiling; Expression Signature; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Products, RNA; Gene Targeting; Genes; Genes, Regulator; Genes, p53; HNSCC; HPV; HPV 16; HPV oncogene; HPV-16; HPV16; Head and Neck Carcinoma; Head and Neck Squamous Cell Carcinoma; Human Papillomavirus; Human papilloma viral oncogene; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus type 16; Human papillomavirus, type 16; Immunologic, Luciferase; Individual; Infectious Human Wart Virus; Laboratories; Lead; Luciferases; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Oropharyngeal Neoplasm; Malignant Oropharyngeal Tumor; Malignant Tumor; Malignant Tumor of the Mouth; Malignant Tumor of the Oropharynx; Malignant neoplasm of mouth; Malignant neoplasm of oropharynx; Messenger RNA; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Micro RNA; MicroRNAs; Molecular Fingerprinting; Molecular Profiling; Mortality; Mortality Vital Statistics; Mouth Cancer; Mouth Mucosa; Mucosa; Mucosal Tissue; Mucous Membrane; Neoplasm Metastasis; Oncogene Products; Oncogene Proteins; Oncogenes; Oncoproteins; Oral; Oral Cancer; Oral Mucosa; Oral mucous membrane structure; Oropharnyx Cancers; Oropharyngeal; Oropharyngeal Cancer; Oropharyngeal Carcinoma; Oropharynx; Oropharynx Cancer; Oropharynxs; P105-RB; P53; PP110; Papilloma Virus, Human; Papillomavirus, Human; Pathway interactions; Pb element; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Profilings, Gene Expression; Quelling; RB1; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Non-Polyadenylated; RNAi; RT-PCR; RTPCR; Radiation; Rb Gene Product; Rb Protein; Rb1 Gene Product; Regulator Genes; Reporter; Retinoblastoma Associated Protein; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Risk Factors; Role; SCCHN; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Skin; Survival Rate; TP53; TP53 gene; TRP53; Targetings, Gene; Time; Tissue Sample; Tobacco; Tobacco Consumption; Tobacco use; Transcript Expression Analyses; Transcript Expression Analysis; Transcriptional Regulatory Elements; Transforming Genes; Translational Inhibition; Translational Repression; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Suppressor Proteins; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Verruca; Verruca vulgaris; Viral Oncogene; Virus; Viruses, General; Warts; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; cancer metastasis; carcinogenesis; chemotherapy; computational analysis; cultured cell line; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; human papilloma virus 16; human papilloma virus oncogene; human papillomaviral oncogene; human papillomavirus oncogene; mRNA; malignancy; malignant mouth neoplasm; malignant oropharynx neoplasm; miRNA; molecuar profile; molecular signature; mutant; neoplasm/cancer; oral carcinogenesis; oral mucosae; oral mucosal; oral pharyngeal; oral tissue; overexpression; pRB; pathway; public health relevance; ray (radiation); regulatory gene; research study; reverse transcriptase PCR; social role; trans acting element; treatment response; tumor suppressor; wart virus",Dysregulation of microRNAs in HPV-Positive Oropharyngeal Cancers,,19749,DSR,NIDR Special Grants Review Committee,A1,1,42180,
7908229,F31,DE,1,,03/01/2010,02/28/2011,PA-09-208,1F31DE020954-01,,NIDCR:31868;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,HOUSTON,UNITED STATES,GENETICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"HOMAN, ERICA PAIGE;",9238969;,1F31DE020954,03/01/2010,02/28/2015,"2-oxoglutarate 3-dioxygenase proline; 4 Hydroxyproline; Address; Affect; Amino Acids; COL1A1; COL1A1 protein; Cartilage; Cartilagenous Tissue; Cell Culture Techniques; Chromosomal, Gene, or Protein Abnormality; Ciclosporin; Collagen; Collagen Alpha 1(I) Chain; Collagen I (Alpha 1); Collagen I, Alpha-1 Polypeptide; Collagen of Skin, Tendon, and Bone, Alpha-1 Chain; Complex; Craniofacial Abnormalities; CsA; Cyclosporin A; Cyclosporine; Cyclosporine A; Cytogenetic or Molecular Genetic Abnormality; Data; Defect; FKBP-70; Fragilitas Ossium; Genetic Abnormality; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hydroxylases; Hydroxylation; Hydroxyproline; Knock-in; Knock-in Mouse; L-Proline; L-Proline, 4-hydroxy-, trans-; Light; Mixed Function Oxidases; Mixed Function Oxygenases; Modification; Molecular; Molecular Abnormality; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Monooxygenases; Mutation; Osteogenesis Imperfecta; Oxyproline; PPIase; Pathogenesis; Peptidyl-Prolyl cis-trans-Isomerase; Peptidylproline cis-trans-isomerase; Peptidylprolyl Isomerase; Phenotype; Photoradiation; Point Mutation; Process; Proline; Proline Isomerase; Proline Rotamase; Prolyl Isomerase; Proteins; Regulation; Role; Sandimmun; SangCya; aminoacid; brittle bone disease; cis-trans-Isomerases; collagen type I, alpha 1 chain; conformation; conformational state; cyclophilin; cyclophilin B; cypB gene product; experiment; experimental research; experimental study; gene product; genome mutation; immunophilin; member; mutant; neoral; ppiB gene product; proline 3-hydroxylase; proline, 2-oxoglutarate 3-dioxygenase; prolyl 3-hydroxylase; protein protein interaction; protein structure; public health relevance; research study; sandimmune; social role; triple helix; type I collagen alpha 1",The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis Imperfecta, Project Narrative This project dissects the role of the enzymatic activity of the P3H1 protein within a collagen modifying complex that serves two roles in the processing of collagen. The results of this project will impact our understanding of the regulation of collagen processing and will shed light on the molecular abnormalities leading to recessive OI.,20954,DSR,NIDR Special Grants Review Committee,,1,31868,
7912721,F31,DE,1,,01/25/2010,01/24/2011,PA-09-208,1F31DE020963-01,,NIDCR:37094;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,RICHMOND,UNITED STATES,DENTISTRY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"CALLAHAN, JILL E;",10121687;,1F31DE020963,01/25/2010,05/24/2011,"Bacteria; Buccal Cavity; Cardiac; Cardiac Valves; Cavitas Oris; Cell Communication and Signaling; Cell Signaling; Cleaved cell; Collection; Coma; Comatose; Competence; D. pneumoniae; D.pneumoniae; DNA; Dental Plaque; Deoxyribonucleic Acid; Diplococcus pneumoniae; Endocarditis; Environment; Esteroproteases; Generalized Growth; Genes; Genetic; Growth; Head and Neck, Buccal Cavity; Heart Valves; Infection; Infective endocarditis; Intracellular Communication and Signaling; Microbial Biofilms; Modeling; Mouth; Oral; Oral cavity; Ortholog; Orthologous Gene; Peptidases; Peptide Hydrolases; Peptides; Play; Pneumococcus; Process; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Regulon; Research; Role; S. mutans; S. pneumoniae; S.mutans; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Site; Streptococcus; Streptococcus Viridans Group; Streptococcus mutans; Streptococcus pneumoniae; System; System, LOINC Axis 4; Tissue Growth; Viridans Streptococci; Virulence; base; biofilm; biological signal transduction; cleaved; fitness; gene product; member; mutant; ontogeny; public health relevance; quorum sensing; screening; screenings; social role; tooth surface; uptake",Characterization of ComC export and processing in Streptococcus sanguinis, The bacterium Streptococcus sanguinis is an important component of dental plaque and may benefit people by competing against harmful bacteria in the mouth. We are characterizing a system in Streptococcus sanguinis that enables it to take up DNA from its surroundings and may also help it survive in the mouth. This study proposes to characterize the most fundamental components of this important system.,20963,DSR,NIDR Special Grants Review Committee,,1,37094,
7810370,F31,DK,1,,04/01/2010,03/31/2011,PA-07-106,1F31DK085961-01,,NIDDK:36672;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ALBANY,UNITED STATES,BIOCHEMISTRY,21,190592162,US,NY,12208,ALBANY MEDICAL COLLEGE,"MELTON, ELAINA MARIE;",9846620;,1F31DK085961,04/01/2010,03/31/2011,"Acid-Thiol Ligases; Acyl CoA; Acyl CoA Synthetases; Acyl Coenzyme A; Acyl Coenzyme A Synthetases; Address; Adipose tissue; Autoregulation; Binding; Binding (Molecular Function); Biochemical; Biological Function; Biological Process; Body Tissues; C 1 Esterase; C1 Esterase; C1 s; C1s; Caco-2 Cells; Caloric Intake; Cardiovascular Diseases; Cell membrane; Cells; Ceramide (lipids); Ceramides; Co A Ligases; Coenzyme A Ligases; Coenzyme A Synthetases; Complement 1 Esterase; Complement 1s; Complement component C1s; Complex; Coupled; Cytoplasmic Membrane; Data; Diabetes Mellitus; Dyslipidemias; Energy Intake; Exhibits; Exons; Expenditure; Family; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Acyl CoA; Fatty Tissue; Goals; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; High Throughput Assay; Homeostasis; Human; Human, General; IC50; Image; Individual; Inhibitory Concentration 50; Integral Membrane Protein; Intestinal; Intestines; Intrinsic Membrane Protein; Isoforms; Kidney; Kinetic; Kinetics; Label; Lead; Libraries; Lipids; Liver; Liver Cells; Long-Chain Acyl CoA; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Molecular Interaction; Obesity; Oxidative Stress; Pathway interactions; Pattern; Pb element; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Property; Property, LOINC Axis 2; Protein Family; Protein Isoforms; Protein Region; Proteins; RNA Splicing; Research; Research Proposals; Resolution; Role; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Substrate Specificity; Temperature; Testing; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Thesaurismosis; Tissues; Transmembrane Protein; Triacylglycerol; Triglycerides; Urinary System, Kidney; Variant; Variation; Very Long Chain Fatty Acid; Work; Yeasts; adenylate; adipose; adiposity; body system, hepatic; bowel; caloric dietary content; cardiovascular disorder; cell type; corpulence; corpulency; corpulentia; diabetes; experiment; experimental research; experimental study; fat metabolism; fatty acid metabolism; fatty acid oxidation; fatty acid transport; fatty acid-transport protein; gene product; heavy metal Pb; heavy metal lead; high throughput screening; imaging; inhibitor; inhibitor/antagonist; insight; knock-down; lipid metabolism; long chain fatty acid; loss of function; member; metabolism disorder; novel; obese; obese people; obese person; obese population; organ system, hepatic; pathway; plasma membrane fatty acid-binding protein; plasmalemma; renal; research study; shRNA; short hairpin RNA; small hairpin RNA; small molecule; social role; stem; therapeutic target; thiokinase; trafficking; translocase; uptake; white adipose tissue; yellow adipose tissue",Characterization of the Biochemical Activities Associated with Human FATP2,,85961,ZRG1,Special Emphasis Panel,,1,36672,
7811556,F31,GM,1,,01/26/2010,01/25/2011,PA-07-106,1F31GM090675-01,,NIGMS:34922;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,BIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"MILTON, ANGENEE CARY;",9714902;,1F31GM090675,01/26/2010,01/25/2013,"Binding; Binding (Molecular Function); Body Tissues; Boxing; C elegans; C.elegans; Caenorhabditis elegans; Cis-Acting Locus; Cis-Acting Sequence; Complex; Development; Ectopic Expression; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Enhancers; Family; Gene Expression; Genes; Genes, Reporter; Genetic; Goals; Head and Neck, Pharynx; In element; Indium; Libraries; Molecular Genetic; Molecular Genetics; Molecular Interaction; Muscle; Muscle Development; Muscle Tissue; Muscle structure of pharynx; Muscular Development; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Pathway interactions; Pharyngeal Muscles; Pharyngeal structure; Pharynx; Pharynxs; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primordium; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Reporter; Reporter Genes; Sequence-Specific Posttranscriptional Gene Silencing; Specific qualifier value; Specified; Temperature; Throat; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Work; base; feeding; member; mutant; neuronal; pathway; trans acting factor (genetic); transcription factor",Characterization of upstream factors regulating the C. elegans T-box gene tbx-2,,90675,ZRG1,Special Emphasis Panel,,1,34922,
7811383,F31,HD,1,,01/20/2010,01/19/2011,PA-07-106,1F31HD063345-01,,NICHD:41380;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BALTIMORE,UNITED STATES,MISCELLANEOUS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"PILGRIM, NANLESTA AUTUMN;",9806853;,1F31HD063345,01/20/2010,06/19/2011,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adolescent; Adolescent Youth; Affect; Africa South of the Sahara; Age; Analysis, Data; Belief; Cessation of life; Characteristics; Cohort Studies; Communities; Concurrent Studies; Condom; Condoms, Unspecified; Data; Data Analyses; Death; Development; Dimensions; Disadvantaged; Education; Educational aspects; Effectiveness; Environment; Equation; Family; Female; Female Adolescents; HIV; HIV Infections; HIV Prevention; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Sciences; Home; Home environment; Household and Family; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Male Adolescents; Measures; Mediating; Modeling; Multiple Partners; Multivariate Analyses; Multivariate Analysis; Partners, Multiple; Pathway interactions; Personal Satisfaction; Play; Policies; Population Study; Prevention; Programs (PT); Programs [Publication Type]; Public Health; Publishing; Research; Risk; Risk Behaviors; Risky Behavior; Role; Rural; Sexual Partners; Socio-economic status; Socioeconomic Status; Status, Socioeconomic; Structure; Sub-Saharan Africa; Subsaharan Africa; Survey Instrument; Surveys; Survival Analyses; Survival Analysis; T-Lymphotropic Virus Type III Infections, Human; Time; Uganda; Virus-HIV; adolescent boy; adolescent girl; at risk behavior; base; cohort; condoms; epidemiological model; experience; family influence; intervention design; juvenile; juvenile human; pathway; programs; public health medicine (field); sex; sex partner; sex risk; sexual coercion; sexual debut; social role; therapy design; treatment design; well-being","Effects of Family Environment on HIV Risk Behavior in Ugandan Females, ages 15-19",,63345,ZRG1,Special Emphasis Panel,,1,41380,
7811219,F31,HD,1,,02/01/2010,01/31/2011,PA-07-106,1F31HD063473-01,,NICHD:25612;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW YORK,UNITED STATES,PSYCHOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"RAMOS, MARIA DE LOS ANGELES;",9828872;,1F31HD063473,02/01/2010,02/28/2011,"0-11 years old; 12-20 years old; Accounting; Adaptation, Psychologic; Adaptation, Psychological; Address; Adherence; Adherence (attribute); Adolescence; Adolescent; Adolescent Youth; Age; Area; Asthma; Attention; Biological; Bronchial Asthma; Buffers; Characteristics; Child; Child Youth; Children (0-21); Cognitive; Cognitive Discrimination; Conflict; Conflict (Psychology); Data; Data Set; Dataset; Development; Disadvantaged; Discrimination; Discrimination (Psychology); Distress; Economic Income; Economical Income; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethnic Origin; Ethnic and Racial Minorities; Ethnic group; Ethnicity; Ethnicity aspects; Exposure to; Face; Funding; Generalized Growth; Growth; Health; Health Status; High Prevalence; Hispanic Populations; Hispanics; Hispanics or Latinos; Home; Home environment; Human, Child; Immigrant; Income; Individual; Interview; Latino Population; Level of Health; Life; Literature; Longitudinal Studies; Los Angeles; Measures; Methods and Techniques; Methods, Other; Minority; Minority Groups; Modeling; Monitor; New York; Outcome; Outcome Measure; Parents; Participant; Population; Preventive Intervention; Probability Samples; Process; Psychological adjustment; Public Health; Puerto Rican; Puerto Rico; Relative; Relative (related person); Reporting; Research; Risk; Risk Factors; Role; Samples, Probability; Sampling; Site; Social Environment; Social status; Spanish Origin; Stress; Symptoms; Techniques; Testing; Time; Tissue Growth; Violence; Youth; Youth 10-21; adolescence (12-20); aged; children; cultural values; ethnic minority; ethnic minority population; experience; facial; hispanic community; interest; juvenile; juvenile human; long-term study; low socioeconomic status; methods to study multiple-level influences; metropolitan; minority health; multilevel analysis; multilevel model; multilevel modeling; ontogeny; parent monitoring; parental monitoring; physical conditioning; preventional intervention strategy; psychologic; psychological; psychological distress; public health medicine (field); resilience; social; social climate; social context; social role; socioenvironment; stem; stressor; teenage; violent; violent behavior; youngster",Risk and protective factors for Puerto Rican children's distress in two contexts,,63473,ZRG1,Special Emphasis Panel,,1,25612,
7810411,F31,HL,1,,02/01/2010,01/31/2011,PA-07-106,1F31HL099275-01,,NHLBI:41380;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,BIOMEDICAL ENGINEERING,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"AREVALO, HERMENEGILD JAVIER;",9836631;,1F31HL099275,02/01/2010,01/31/2013,"Ablation; Action Potentials; Adoption; Architecture; Arrhythmia; Basic Research; Basic Science; Body Tissues; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cardiac ablation; Cardiac infarction; Catheter Ablation; Cells; Characteristics; Cicatrix; Communicating Junction; Complex; Computer Simulation; Computerized Models; Data; Deposit; Deposition; Development; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Drug or chemical Tissue Distribution; Engineering / Architecture; FLR; Failure (biologic function); Family suidae; Fibroblasts; Gap Junctions; Healed; Heart; Heart Arrhythmias; Heart Diseases; Image; Infarction; Inflammatory; Ion Channel; Ionic Channels; Knowledge; Lead; Lesion; Location; Low-resistance Junction; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mathematical Model Simulation; Mathematical Models and Simulations; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane Channels; Methods and Techniques; Methods, Other; Mission; Modeling; Models, Computer; Morphology; Muscle Cells; Muscle Cells, Mature; Myocardial Infarct; Myocardial Infarction; Myocytes; NMR Imaging; NMR Tomography; National Heart, Lung, and Blood Institute; Nexus; Nexus Junction; Nuclear Magnetic Resonance Imaging; Pathway interactions; Patients; Pb element; Perfusion; Physiologic; Physiological; Pigs; Procedures; Research; Resolution; Role; Scars; Simulation, Computer based; Site; Structure; Suidae; Swine; Tachycardia, Ventricular; Techniques; Testing; Tissue Distribution; Tissues; Ventricular Tachycardia; Zeugmatography; base; cardiac infarct; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; coronary attack; coronary infarct; coronary infarction; diffusion tensor imaging; failure; healing; heart attack; heart disorder; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; imaging; in silico; infarct; insight; novel; pathway; porcine; prevent; preventing; shape analysis; shape description; social role; spatiotemporal; suid; tool; virtual simulation",Image-based models that predict arrhythmia morphology in post-infarction hearts,,99275,ZRG1,Special Emphasis Panel,,1,41380,
7811767,F31,HL,1,,02/01/2010,01/31/2011,PA-07-106,1F31HL099653-01,,NHLBI:37116;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"WEIGAND, LETITIA ALEXIS;",9893727;,1F31HL099653,02/01/2010,04/30/2012,"Action Potentials; Acute; Address; Allergens; Allergic; Allergic Disease; Allergic inflammation; Anatomic; Anatomical Sciences; Anatomy; Autonomic Nerve; Autonomic nerve structure; Basophilic Histiocyte; Basophils, Tissue; Body Tissues; Bone Marrow; Breathlessness; Bronchi; Bronchial Spasm; Bronchospasm; C Fiber; Coughing; Cranial Nerve X; Disease; Disorder; Dysfunction; Dyspnea; Dyspneas; Electrophysiology; Electrophysiology (science); Functional disorder; Ganglia, Sensory; Goals; Grant; Immunomodulation; Itching; Lead; Lung; Mammals, Mice; Marrow Mast Cell; Mice; Mucous body substance; Mucus; Murine; Mus; Neurophysiology / Electrophysiology; Nociception; Ovalbumin; Pb element; Peripheral Nerves; Physiopathology; Pneumogastric Nerve; Property; Property, LOINC Axis 2; Pruritic Disorder; Pruritis; Pruritus; Pulmonary Body System; Pulmonary Organ System; Reflex; Reflex action; Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Reticuloendothelial System, Bone Marrow; Role; Science of Anatomy; Science of neurophysiology; Sensory; Sensory Ganglia; Sneezing; Sneezings; Symptoms; Tenth Cranial Nerve; Tissues; Trachea; Trachea Proper; Tracts, Respiratory; Vagus Nerve; Vagus nerve structure; afferent nerve; allergic airway disease; anatomy; autonomic nerve; disease/disorder; experiment; experimental research; experimental study; extracellular; heavy metal Pb; heavy metal lead; immune modulation; immunologic reactivity control; immunoregulation; innervation; mast cell; mastocyte; mouse model; mucous; nerve supply; neurophysiology; new therapeutics; next generation therapeutics; nociceptive; novel therapeutics; pathophysiology; pulmonary; reconstitute; reconstitution; research study; respiratory tract; response; sensory nerve; social role; windpipe",Immunomodulation of Vagal Innervation in the Respiratory Tract,,99653,ZRG1,Special Emphasis Panel,,1,37116,
7811315,F31,HL,1,,02/01/2010,01/31/2011,PA-07-106,1F31HL099654-01,,NHLBI:31986;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,PHYSIOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"GARCIA, MONICA DEANA;",9836711;,1F31HL099654,02/01/2010,01/31/2012,"3,4',5-stilbenetriol; 3,5,4'-trihydroxystilbene; Affect; American Heart Association; Apoptosis; Apoptosis Pathway; Apoptotic; Behavior; Birth Defects; Blood Island; Blood Vessels; Blood capillaries; Blood flow; Blotting, Western; Capillaries; Capillary; Capillary, Unspecified; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Cycle Genes; Cell Death; Cell Death, Programmed; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Migration; Cellular Morphology; Cellular Physiology; Cellular Process; Cessation of life; Confocal Microscopy; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Death; Defect; Development; Drugs; Embryo; Embryonic; Endothelial Cells; Equilibrium; Erythroblasts; Erythrocytes, Nucleated; Future; Genes, Cell Division Cycle; Genes, cdc; Genetic Alteration; Genetic Change; Genetic defect; Globin; Health; Image; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Lead; Learning; Life; Mammals, Mice; Medication; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Confocal; Molecular; Molecular Genetic Abnormality; Morphology; Motility; Motility, Cellular; Movement; Murine; Mus; Mutation; Normoblasts; Nucleated red blood cell; Nucleated red cell; Null Mouse; Organ System, Cardiovascular; Pathology; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Protein Phosphorylation; Regulation; Reporter; Resveratrol; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; System; System, LOINC Axis 4; Techniques; Testing; Time; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular remodeling; Vascular, Heart; Western Blotting; Western Blottings; Western Immunoblotting; Yolk Sac; balance; balance function; biological signal transduction; body movement; capillary; cardiovascular disorder; cdc Genes; cell behavior; cell morphology; cell motility; circulatory system; drug/agent; embryo culture; experiment; experimental research; experimental study; gain of function; genome mutation; heavy metal Pb; heavy metal lead; imaging; in vivo; insight; loss of function; migration; necrocytosis; nucleated RBCs; p-Globin; pathway; protein blotting; research study; response; social role; time use; tool; vascular; vitelline sac",FoxO1 regulation of endothelial cellular function during vascular remodeling,,99654,ZRG1,Special Emphasis Panel,,1,31986,
7911484,F31,NR,1,,05/01/2010,04/30/2011,PAR-09-227,1F31NR012100-01,,NINR:41380;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,PHILADELPHIA,UNITED STATES,NONE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LYONS, MARY MELANIE;",10067879;,1F31NR012100,05/01/2010,04/30/2013,"70-kD Heat-Shock Protein; AIDS Virus; ARDS; ARDS, Human; ARDSs, Human; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Activities of Daily Living; Activities of everyday life; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Adult RDS; Adult Respiratory Distress Syndrome; Affect; Attenuated; Behavior; Cause of Death; Cellular injury; Chimera Protein; Chimeric Proteins; Closure by Ligation; Critical Illness; Critical Illness Polyneuropathy; Critically Ill; Development; Disease; Disorder; Dysfunction; Early Mobilizations; Epithelial Cells; Family; Functional disorder; Fusion Protein; HIV; HSP; HSP 70; HSP70; HTLV-III; Heat Shock; Heat-Shock Proteins 70; Heat-Shock Reaction; Heat-Shock Response; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; INFLM; Inflammation; Injection of therapeutic agent; Injections; Intensive Care Units; Intervention; Intervention Strategies; LAV-HTLV-III; Length of Stay; Ligation; Locomotor Activity; Lung; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Mechanical Ventilator Weaning; Mechanical ventilation; Mission; Mobilizations, Early; Mortality; Mortality Vital Statistics; Motor Activity; Muscle; Muscle Tissue; Number of Days in Hospital; Nurses; Organ; Organ System; Outcome; Patients; Personnel, Nursing; Physiopathology; Proteins; Puncture procedure; Punctures; QOL; Quality of life; Recovery; Research; Research Training; Respirator Weaning; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Rodent Model; Role; Scientist; Sepsis; Severities; Shock Lung; Survivors; Syndrome; System; System, LOINC Axis 4; Therapeutic; Therapeutic Agents; Ventilator Weaning; Virus-HIV; adeno vector; adenovector; bloodstream infection; body system; cell damage; cell injury; cell type; daily living functionality; disease prevention; disease/disorder; disorder prevention; functional ability; functional capacity; gene product; hospital days; hospital length of stay; hospital stay; hsp70 Family; improved; interventional strategy; lung injury; mechanical respiratory assist; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathophysiology; public health relevance; pulmonary; respiratory; social role","A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS"," Project Narrative This proposal is a first of its kind, novel study of the role of HSP70 in decreasing lung injury, mortality and increasing locomotor activity in a sepsis induced Acute Respiratory Distress Syndrome rodent model. It evaluates a novel therapeutic agent for disease prevention, treatment, and improving patient quality of life.",12100,NRRC,National Institute of Nursing Research Initial Review Group,,1,41380,
7809275,F31,NS,1,,02/01/2010,01/31/2011,PA-07-002,1F31NS064730-01A1,,NINDS:32436;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WOODWORTH, MOLLIE ANN;",9390214;,1F31NS064730,02/01/2010,01/31/2013,"ALS; Affect; Age; Amyotrophic Lateral Sclerosis; Axon; Binding; Binding (Molecular Function); Brain; COUP transcription factor; COUP-TF; Cells; Cerebral Peduncle; Cerebral cortex; Clinical; Compensation; Complement; Complement Proteins; Corpus Striatum; Corpus striatum structure; Crus Cerebri; Cues; Defect; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Embryo; Embryonic; Encephalon; Encephalons; Family member; Fasciculation; Fasciculation, Muscular; Fasciculation, Neural; Financial compensation; Fore-Brain; Forebrain; Future; Gehrig's Disease; Generalized Growth; Generations; Genes; Genetic Algorithm; Genetic Programming; Goals; Growth; Growth Cones; Immune system; Individual; Internal Capsule; Investigation; Investigators; Knockout Mice; Laboratories; Lou Gehrig Disease; Mammals, Mice; Medulla Spinalis; Mesencephalon; Mice; Mice, Knock-out; Mice, Knockout; Mid-brain; Midbrain; Midbrain structure; Molecular; Molecular Interaction; Mother Cells; Motor Cell; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Murine; Mus; Muscle fasciculation; Myelopathy, Traumatic; NRVS-SYS; Nature; Neocortex; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Null Mouse; Phenotype; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Population; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Proteins; Research; Research Design; Research Personnel; Researchers; Role; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stem cells; Striate Body; Striatum; Study Type; System; System, LOINC Axis 4; Telencephalon; Tissue Growth; Travel; Work; axon growth cone guidance; axon guidance; body system, allergic/immunologic; cellular development; chicken ovalbumin upstream promoter-transcription factor; combinatorial; disease/disorder; experiment; experimental research; experimental study; gene product; homotypical cortex; insight; isocortex; motoneuron; motor neuron development; neocortical; neopallium; neuronal; ontogeny; organ system, allergic/immunologic; postnatal; progenitor; programs; repair; repaired; research study; social role; striatal; study design; transcription factor",Ctip2 Function in Corticospinal Motor Neuron Development,,64730,ZRG1,Special Emphasis Panel,A1,1,32436,
7804948,F31,NS,1,,02/01/2010,01/31/2011,PA-07-002,1F31NS067740-01,,NINDS:36492;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,PATHOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"WARD, AMANDA JOY;",9850251;,1F31NS067740,02/01/2010,01/31/2013,"2 Dimensional Gel Electrophoresis; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 21+ years old; 3' Untranslated Regions; 3'UTR; Address; Adeno-Associated Viruses; Adult; Alternate Splicing; Alternative Splicing; Antibodies; Assay; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Blotting, Western; Body Tissues; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cardiac; Cardiotoxin; Cause of Death; Cell Nucleus; Chemicals; Cobra Cardiotoxin; Dependovirus; Direct Lytic Factors; Disease; Disorder; Doxycycline; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Dystrophia Myotonica; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Ellis-van Creveld (EvC) syndrome; Event; Exercise Test; Exercise stress test; Exhibits; Gene Products, RNA; Gene Targeting; Genes; Half-Life; Half-Lifes; Heart; Histology; Human; Human, Adult; Human, General; Injection of therapeutic agent; Injections; Injury; Insulin Resistance; Ligand Binding Protein; Limb-Girdle Muscular Dystrophies; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Merosin; Mice; Mice, Transgenic; Modeling; Murine; Mus; Muscle; Muscle Proteins; Muscle Tissue; Muscle function; Muscle, Skeletal; Muscle, Voluntary; Muscular Dystrophies; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Myodystrophica; Myodystrophy; Myotonia; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Natural regeneration; Neuromuscular Diseases; Nuclear; Nucleus; PKC; Pathway interactions; Patients; Phenocopy; Phenotype; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Play; Prevalence; Progressive Muscular Dystrophy, Duchenne Type; Protein Kinase C; Protein Kinase C Inhibitor; Protein Phosphorylation; Proteins; Pseudohypertrophic Muscular Dystrophy, Childhood; Public Health; RNA; RNA Splicing; RNA Splicing, Alternative; RNA, Non-Polyadenylated; Recombinant adeno-associated virus; Recombinant adeno-associated virus (rAAV); Regeneration; Reporting; Ribonucleic Acid; Role; Sampling; Side; Skeletal Muscle Tissue; Skeletal muscle structure; Specificity; Splicing; Steinert Disease; Symptoms; Targetings, Gene; Testing; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Time; Tissues; Toxin; Trans-Acting Factors; Trans-Activators; Transactivators; Transgenic Mice; Trinucleotide Repeats; Triplet Repeats; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vibramycin; Weight; Western Blotting; Western Blottings; Western Immunoblotting; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; adeno associated virus group; adult human (21+); alpha-6-Deoxyoxytetracycline; benign X-linked recessive muscular dystrophy; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; codon reiteration; congenital muscular dystrophy; disease/disorder; experiment; experimental research; experimental study; gain of function; gene product; improved; inhibitor; inhibitor/antagonist; injured; insulin resistant; knock-down; limb-girdle muscular weakness and atrophy; limb-girdle syndrome; mild X-linked recessive muscular dystrophy; mouse model; muscle degeneration; muscular dystrophy mouse model; myoneural disorder; myopathic limb-girdle syndrome; neuromuscular disorder; notexin; pathway; prevent; preventing; progressive muscular dystrophy of childhood; protein blotting; protein expression; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; public health medicine (field); regenerate; research study; response; shRNA; short hairpin RNA; skeletal muscle wasting; small hairpin RNA; social role; trans acting factor (genetic); ward; wasting",Role of CUGBP1 in skeletal muscle wasting in myotonic dystrophy,,67740,ZRG1,Special Emphasis Panel,,1,36492,
7810461,F31,NS,1,,02/01/2010,01/31/2011,PA-07-106,1F31NS068036-01,,NINDS:32462;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,ANESTHESIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"IBARRA, YESSENIA M;",7881954;,1F31NS068036,02/01/2010,01/31/2013,"2-Propanone; 5,6,7,8-tetrahydrobiopterin; Acetone; Adverse effects; Affect; Afferent Neurons; Allergy; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Aromatic Amines; Arylamines; Autoregulation; BH4; BPH4; Behavioral; Blood Coagulation Factor IV; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Body; Cell Death; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Closure by Ligation; Coagulation Factor IV; Common Rat Strains; DNA Alteration; DNA mutation; Dimethyl formaldehyde; Dorsal Root Ganglia; Down-Regulation; Down-Regulation (Physiology); Downregulation; Electrophysiology; Electrophysiology (science); Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Factor IV; Filament; Ganglia, Spinal; Gene Alteration; Gene Mutation; Gene Transcription; Genetic; Genetic Transcription; Genetic mutation; H4B; H4biopterin; Haplotypes; Homeostasis; Human; Human, General; Hydroxylases; Hypersensitivity; Image; Injury; Intervention; Intervention Strategies; Ion Channel; Ion Channels, Calcium; Ionic Channels; Knockout Mice; Lead; Ligation; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Medulla Spinalis; Membrane Channels; Membrane Potentials; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mixed Function Oxidases; Mixed Function Oxygenases; Modeling; Molecular Target; Mononitrogen Monoxide; Monooxygenases; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology / Electrophysiology; Neurotransmitters; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nociceptors; Null Mouse; Pain; Painful; Pathway interactions; Patients; Pb element; Peripheral; Peripheral Nerves; Peripheral nerve injury; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiological Homeostasis; RNA Expression; Rat; Rattus; Receptor Protein; Receptors, Calcium Channel Blocker; Resting Potentials; Rodent Model; Role; Sensory Cell Afferent Neuron; Sequence Alteration; Signaling Molecule; Spinal Cord; Spinal Ganglia; Spinal Nerves; Spinal nerve structure; Stimulus; Subcellular Process; Symptoms; THBP; Techniques; Test Result; Testing; Time; Transcription; Transcription, Genetic; Transgenic Mice; Transmembrane Potentials; Transmission; Treatment Side Effects; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); VDCC; Voltage-Dependent Calcium Channels; allodynia; analgesia; behavior test; behavioral test; cell body (neuron); chronic neuropathic pain; chronic pain; chronic painful condition; cofactor; dorsal root ganglion; endothelial cell derived relaxing factor; heavy metal Pb; heavy metal lead; imaging; injured; interventional strategy; necrocytosis; nerve injury; neural cell body; neural injury; neuronal; neuronal cell body; neuronal growth; neuropathic pain; neurotransmitter release; painful neuropathy; pathway; prevent; preventing; receptor; repair; repaired; side effect; social role; soma; tetrahydro-6-biopterin; tetrahydrobiopterin; therapy adverse effect; transmission process; treatment adverse effect; voltage",Tetrahydrobioperin acts as a pain signaling molecule,,68036,ZRG1,Special Emphasis Panel,,1,32462,
7811357,F31,NS,1,,02/01/2010,01/31/2011,PA-07-106,1F31NS068038-01,,NINDS:27928;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,OTOLARYNGOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"COUTINHO-BUDD, JAEDA ;",9279074;,1F31NS068038,02/01/2010,01/31/2013,"0-6 weeks old; 4-3 Hydrophobic Repeat; Actins; Amino Acids; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Binding; Binding (Molecular Function); Biochemical; Brain; C-terminal; Cell Communication and Signaling; Cell Culture Techniques; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Cerebral cortex; Charge; Co-Immunoprecipitations; Code; Coding System; Coiled-Coil Domain; Complex; Cues; Cytoskeletal System; Cytoskeleton; Defect; Dendrites; Dependence; Development; Disease; Disorder; Drosophila sli protein; Dysfunction; Electroporation; Encephalon; Encephalons; Endocytosis; Filopodia; Functional disorder; GAP Proteins; GTPase-Activating Proteins; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glutamates; Human; Human, General; In Vitro; Infant, Newborn; Intervening Sequences; Intracellular Communication and Signaling; Introns; Kanner's Syndrome; Knockout Mice; L-Glutamate; Lead; Left-Handed Twist; Length; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane; Mental Retardation; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microtubules; Modeling; Molecular; Molecular Interaction; Morphogenesis; Morphology; Murine; Mus; Mutation; N-terminal; NH2-terminal; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurites; Neurocyte; Neuronal Differentiation; Neurons; Newborn Infant; Newborns; Null Mouse; Pathology; Pb element; Physiopathology; Play; Point Mutation; Process; Protein Conformation; Proteins; Proteomics; Pyramidal neuron; Regulation; Role; Schizophrenia; Schizophrenic Disorders; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; T-Cells; T-Lymphocyte; Techniques; Testing; Thymus-Dependent Lymphocytes; aminoacid; biological signal transduction; dSlit protein, Drosophila; dementia praecox; disease/disorder; extracellular; gene product; genome mutation; guanosinetriphosphatase activating protein; heavy metal Pb; heavy metal lead; hippocampal pyramidal neuron; improved; in vivo; in vivo Model; intracellular skeleton; lissencephaly; loss of function; membrane structure; migration; mutant; neurite growth; neuronal; neuropathology; newborn human (0-6 weeks); novel; overexpression; pathophysiology; prevent; preventing; response; rho; schizophrenic; sli protein, Drosophila; slit protein; social role; thymus derived lymphocyte; wdh protein, Drosophila",analysis of srGAP2 in cortical development in vitro and in vivo,,68038,ZRG1,Special Emphasis Panel,,1,27928,
7806735,F32,AR,1,,01/25/2010,01/24/2011,PA-07-107,1F32AR058079-01,,NIAMS:50474;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"ACKERMANN, MAEGEN ALLYSUM;",7879246;,1F32AR058079,01/25/2010,01/24/2013,"21+ years old; ATPase, Actin-Activated; Actin Filaments; Action Potentials; Adenosine Triphosphatase, Myosin; Adult; Autoregulation; Binding; Binding (Molecular Function); Biochemical; Cardiac; Cardiomyopathy, Dilated; Cellular Matrix; Chromosomes; Cold-Insoluble Globulins; Confocal Microscopy; Congestive Cardiomyopathy; Cytoskeletal System; Cytoskeleton; Data; Defect; Development; Dilated Cardiomyopathy; Disorder of muscle, unspecified; Down-Regulation; Down-Regulation (Physiology); Downregulation; Electroporation; Embryo Development; Embryogenesis; Embryonic Development; Expression Profiling; Expression Signature; FN1; FNZ; Fiber; Fibronectin 1; Fibronectins; Filament; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic defect; Heart; Homeostasis; Housing; Human, Adult; Imaging Procedures; Imaging Techniques; Immune Globulins; Immunofluorescence; Immunofluorescence Immunologic; Immunoglobulins; Immunoglobulins / Antibodies; Immunologic, Immunofluorescence; Isoforms; Knock-in; Knock-in Mouse; Knowledge; LETS Proteins; Large External Transformation-Sensitive Protein; Length; Maintenance; Maintenances; Mammals, Mice; Manuscripts; Measurement; Mediating; Membrane; Methods; Mice; Microfilaments; Microscopy; Microscopy, Confocal; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monitor; Morphology; Murine; Mus; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Diseases; Muscular Dystrophies; Mutation; MyBP-C protein; Myodystrophica; Myodystrophy; Myofibrils; Myofilaments; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Myotubes; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Pattern; Phosphorylation Site; Physiologic; Physiological; Physiological Homeostasis; Play; Protein Isoforms; Proteins; Public Health; RNA; RNA Splicing; RNA, Non-Polyadenylated; Regulation; Relative; Relative (related person); Relaxation; Research; Rest; Rhabdomyocyte; Ribonucleic Acid; Role; Sarcomeres; Sarcoplasmic Reticulum; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Slide; Splicing; System; System, LOINC Axis 4; Technics, Imaging; Technology; Testing; Thick; Thick Filament; Thickness; Thin Filament; Translating; Translatings; Variant; Variation; adult human (21+); alpha 2-Surface Binding Glycoprotein; experiment; experimental research; experimental study; flexor digitorum brevis; gene product; genome mutation; in vivo; intracellular skeleton; knock-down; language translation; membrane structure; molecuar profile; molecular signature; muscular disorder; myosin ATP phosphohydrolase (actin translocating); myosin-binding protein C; novel; obscurin; public health medicine (field); research study; scaffold; scaffolding; skeletal; social role; tool; uptake",MyBP-C slow variant 1: a slow isoform in a fast muscle,,58079,ZRG1,Special Emphasis Panel,,1,50474,
7807636,F32,AR,1,,02/01/2010,01/31/2011,PA-07-107,1F32AR058122-01,,NIAMS:46590;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LA JOLLA,UNITED STATES,ENGINEERING (ALL TYPES),53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"RAUB, CHRISTOPHER B;",8620408;,1F32AR058122,02/01/2010,01/31/2013,"21+ years old; 3-D; 3-Dimensional; Adherent Culture; Adult; Affect; Alginates; American; Apoptosis; Apoptosis Pathway; Arthritis; Arthritis, Degenerative; Biocompatible; Body Tissues; Bovine Species; CSBP1; CSBP2; CSPB1; Cachectin; Cachectin-Tumor Necrosis Factor; Cartilage; Cartilage injury; Cartilage, Articular; Cartilagenous Tissue; Cattle; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell-Extracellular Matrix; Cells; Chemicals; Chondrocytes; Collagen; Data; Defect; Degenerative polyarthritis; Deposit; Deposition; Development; Dimensions; Disease; Disorder; Dose; ECM; EXIP; Elements; Embryo; Embryonic; Engineering; Engineerings; Environmental Factor; Environmental Risk Factor; Esteroproteases; Event; Extracellular Matrix; Extracellular Signal-Regulated Kinase Gene; Gene Targeting; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Generations; Genes; Genetic; Genetic Algorithm; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic Intervention; Genetic Programming; Genetic defect; Glycosaminoglycans; Goals; Growth; HTRPY; Harvest; Human, Adult; Hypertrophy; Image; Immunoglobulin Enhancer-Binding Protein; In Vitro; Inflammatory; Injury; Intervention, Genetic; Intracellular Communication and Signaling; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; Knock-out; Knockout; Knockout Mice; Knowledge; Laboratories; Load-Bearing; Loadbearing; MAP Kinase 8 Gene; MAP Kinase Gene; MAP-ERK Kinase; MAP2K6; MAP2K6 gene; MAPK; MAPK ERK Kinases; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; MAPKK6; MEK6; MEKs; MKK6; Mammals, Mice; Math Models; Mechanics; Mentors; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microscopy; Mission; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular Biology, Gene Therapy; Monolayer culture; Mucopolysaccharides; Murine; Mus; Mutation; Mxi2; NF-kB; NF-kB Signaling Pathway; NF-kappa B; NF-kappaB; NFKB; NFKB Signaling Pathway; NIH; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Institutes of Health (U.S.); Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Osteoarthritis; Osteoarthrosis; PRKM14; PRKM15; PRKM8; PRKM9; PRKMK6; Pathway interactions; Peptidases; Peptide Hydrolases; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Population; Procedures; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteoglycan; Proteolytic Enzymes; Relative; Relative (related person); Research; SAPK1; SAPK2A; SAPKK3; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Stress; Structure; Structure of articular cartilage; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Targetings, Gene; Techniques; Therapy, DNA; Thinking; Thinking, function; Time; Tissue Engineering; Tissue Growth; Tissues; Training; Transcription Factor NF-kB; Transgenic Organisms; Trauma; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); United States National Institutes of Health; Weight-Bearing; Weight-Bearing state; Weightbearing; adult human (21+); aggrecan; arthritic; articular cartilage; base; biological signal transduction; bovid; bovine; career; cartilage development; cartilage repair; cow; cross-link; crosslink; degenerative joint disease; disease/disorder; engineered tissue; environmental risk; experience; gene therapy; genetic determinant; genetic therapy; genome mutation; human TNF protein; hypertrophic arthritis; imaging; in vitro Model; kappa B Enhancer Binding Protein; knockout gene; mathematical model; mathematical modeling; multidisciplinary; novel; nuclear factor kappa beta; ontogeny; osteochondral; osteochondral repair; osteochondral tissue; p38; p38 MAPK Gene; p38Alpha; p54aSAPK; pathway; programs; repair; repaired; response; scaffold; scaffolding; second harmonic; skills; surgery; tool; transgenic; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; two-photon",Controlling chondrocyte matrix degradation and repair in 3-D culture.,,58122,ZRG1,Special Emphasis Panel,,1,46590,
7804997,F32,AT,1,,02/01/2010,01/31/2011,PAR-07-319,1F32AT004879-01A2,,NCCAM:70810;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,DENVER,UNITED STATES,PSYCHOLOGY,01,007431760,US,CO,80208,UNIVERSITY OF DENVER,"SHALLCROSS, AMANDA ;",9287934;,1F32AT004879,02/01/2010,01/31/2013,"Address; Affect; Affective; Attention; Clinical; Cognitive; Confounding Factor, Epidemiologic; Confounding Factors (Epidemiology); Confounding Variables; Depressed mood; Depression; Diagnosis; Disease remission; Economic Burden; Elements; Emotional; Emotional Depression; Emotions; Family; Heterogeneity, Population; History; Intervention; Intervention Strategies; Interview; Laboratories; Lead; Lifetime Risk; Literature; Major Depressive Disorder; Measurement; Measures; Mediating; Mediation; Medical; Meditation; Mental Depression; Method LOINC Axis 6; Methodology; Modeling; Nature; Negotiating; Negotiation; Outcome; Participant; Patient Self-Report; Patients; Pb element; Physiologic; Physiological; Population; Population Heterogeneity; Public Health; RMSN; Randomized; Reaction Time; Recording of previous events; Recurrence; Recurrent; Relapse; Relative; Relative (related person); Remission; Research; Research Proposals; Response RT; Response Time; Rest; Risk; SNS; Self-Report; Severities; Social support; Societies; Specificity; Structure; Sympathetic Nervous System; Symptoms of depression; Testing; Therapeutic; Therapeutic Studies; Therapy Research; Time; Training; Uncertainty; World Health; active control; cognitive function; depressed; depressive; depressive symptoms; design; designing; diverse populations; doubt; evidence base; experience; heart rate variability; heavy metal Pb; heavy metal lead; heterogeneous population; improved; interventional strategy; major depression; mindfulness; mindfulness based cognitive therapy; mindfulness meditation; novel; post intervention; psychomotor reaction time; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; sadness; social; social support network",The Effects and Mechanisms of MBCT on Depressive Symtoms and Depression Relapse,,4879,ZAT1,Special Emphasis Panel,A2,1,70810,
7804995,F32,DA,1,,03/01/2010,02/28/2011,PA-07-107,1F32DA026660-01A1,,NIDA:50474;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BRIAND, LISA A;",8407348;,1F32DA026660,03/01/2010,02/28/2013,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ACTH-Releasing Factor; Activation, Gene; Acute; Addiction, Cocaine; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Associative Learning; Bed Nucleus of Stria Terminalis; Behavior; Behavioral; Brain region; CRE Binding Protein; CREB; CREB Protein; CRF-41; CRH; Cell/Tissue, Immunohistochemistry; Cells; Chronic stress; Cocaine; Cocaine Dependences; Conditioning, Classical; Conditionings, Classical; Cornu Ammonis; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Dependences, Cocaine; Drugs; Exhibits; Experimental Designs; Exposure to; Gene Activation; Goals; Grant; Hippocampus; Hippocampus (Brain); Human; Human, General; Hypothalamic structure; Hypothalamus; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Label; Lead; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Mice; Mice, Mutant Strains; Molecular; Murine; Mus; Mutant Strains Mice; Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Nucleus Accumbens; Pattern; Pavlovian conditioning; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Prefrontal Cortex; Public Health; Relapse; Research; Resistance; Rewards; Rodent Model; Role; Science of neurochemistry; Stimulus; Stress; Stria Terminalis Nucleus; Structure of terminal stria nuclei of preoptic region; Swimming; System; System, LOINC Axis 4; Ventral Tegmental Area; Work; amygdaloid nuclear complex; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; classical conditioning; cohort; coping; corticotropin releasing hormone; drug discovery; drug relapse; drug/agent; experience; heavy metal Pb; heavy metal lead; hippocampal; hypothalamic; model organism; mouse mutant; mutant; neural circuit; neural circuitry; neurobiological; neurochemistry; neuronal; new therapeutic target; preference; public health medicine (field); resistant; response; restraint; restraint stress; social role; stressor; ventral tegmentum",The role of CREB in stress-induced reinstatement,,26660,ZRG1,Special Emphasis Panel,A1,1,50474,
7805892,F32,DA,1,,01/25/2010,01/24/2011,,1F32DA026692-01A1,,NIDA:45590;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"MAHLER, STEPHEN VINCENT;",7963456;,1F32DA026692,01/25/2010,01/24/2013,"3(2H)-Isoxazolone, 5-(aminomethyl)-; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 6-Cyano-7-nitroquinoxaline-2,3-dione; 6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Address; Affect; Agarin; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Attenuated; Baclofen; Behavior; Behavioral; Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-; Bilateral; Brain; CNQX; Cell Communication and Signaling; Cell Signaling; Cells; Chlorophenyl GABA; Cocaine; Common Rat Strains; Conditioned Stimulus; Contralateral; Cues; DA Neuron; Dopamine; Dopamine neuron; Drug usage; Drugs; EAA Antagonists; Encephalon; Encephalons; Excitatory Amino Acid Antagonists; Exposure to; Fore-Brain; Forebrain; GABA Agonists; GABA Receptor Agonists; Glutamate Antagonists; Glutamate Receptor; Glutamate Receptor Antagonists; Glutamates; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Human; Human, General; Hydroxytyramine; Intracellular Communication and Signaling; Ipsilateral; Knowledge; L-Glutamate; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medial; Mediating; Medication; Methods; Methods and Techniques; Methods, Other; Microinjections; Modeling; Muscimol; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurosciences; PCP-GABA; Pantherine; Pharmaceutic Preparations; Pharmaceutical Preparations; Prefrontal Cortex; Procedures; Process; Prosencephalon; Proteins; Randomized; Rat; Rattus; Receptor Protein; Relapse; Rewards; Risk Factors; Role; Self Administration; Self-Administered; Signal Transduction; Signal Transduction Systems; Signaling; Source; Staining method; Stainings; Stains; Stimulus; Structure; System; System, LOINC Axis 4; Tag; Techniques; Testing; Time; Tracer; Training; Ventral Tegmental Area; addiction; amygdaloid nuclear complex; behavior measurement; behavioral measure; behavioral measurement; behavioral pharmacology; beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid; beta-(p-Chlorophenyl)-gamma-aminobutyric Acid; biological signal transduction; cocaine exposure; dopaminergic neuron; drug relapse; drug seeking behavior; drug use; drug/agent; experiment; experimental research; experimental study; gamma-Aminobutyric Acid Agonists; gene product; hypocretin; hypocretin/orexin; hypocretins/orexins; intervention development; model organism; multidisciplinary; neural circuit; neural circuitry; neuronal; orexin; prevent; preventing; randomisation; randomization; randomly assigned; receptor; research study; social role; therapy development; treatment development; ventral tegmentum",VTA Glutamate and Orexin Involvement in Cue Reinstatement of Drug Seeking,,26692,ZRG1,Special Emphasis Panel,A1,1,45590,
7808187,F32,DA,1,,01/15/2010,01/14/2011,,1F32DA028080-01,,NIDA:47604;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,STORRS-MANSFIELD,UNITED STATES,BIOCHEMISTRY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"STADEL, REBECCA ;",9831141;,1F32DA028080,01/15/2010,01/14/2013,"6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-; 9-ene-Tetrahydrocannabinol; Absence of pain sensation; Absence of sensibility to pain; Adverse effects; Affinity; Agonist; Amino Acids; Ammon Horn; Anxiety; Appetite; Arrestins; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Weight decreased; CB1 Receptor; Cannabinoids, Endogenous; Cell Line; Cell Lines, Strains; CellLine; Cells; Central Nervous System; Cessation of smoking; Chemicals; Classification; Co-Immunoprecipitations; Complex; Confocal Microscopy; Cornu Ammonis; Delta-9-Tetrahydrocannabinol; Depression; Desire for food; Development; Dronabinol; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug abuse; Endocannabinoids; Environment; Event; Family; Feels no pain; G Protein Go; G Protein-Complex Receptor; G(o) Protein; G-Protein, Go Subunit; G-Protein, Inhibitory Go; G-Protein-Coupled Receptors; GTP Binding Protein alpha Subunit, Go; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Go Alpha Subunit; Goals; Guanine Nucleotide-Binding Protein Go; Hippocampus; Hippocampus (Brain); Hypothermia; In Vitro; Individual; Label; Lead; Learning; Length; Link; Marihuana; Marinol; Measures; Memory; Mental Depression; Microscopy, Confocal; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Mutation; Nature; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; No sensitivity to pain; Nuclear Magnetic Resonance; Pathway interactions; Pb element; Process; Receptor Activation; Receptor Protein; Receptor, Cannabinoid, CB1; Relative; Relative (related person); Role; Sedation procedure; Site; Structure; Systematics; Tetrahydrocannabinol; Therapeutic; Time; Treatment Side Effects; Visual; Weight Loss; Weight Reduction; abuse of drugs; abuses drugs; aminoacid; analgesia; arr3; arrestin 1; arrestin 2; arrestin 3; arrestin B; arrestin3; beta-arrestin; body weight loss; cannabinoid receptor; cease smoking; cultured cell line; delta(1)-THC; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; desensitization; drug craving; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; hippocampal; hypothermia, natural; improved; in vivo; interest; natural hypothermia; neuronal; novel; pathway; prevent; preventing; receptor; receptor binding; receptor internalization; research study; sedation; side effect; smoking cessation; social role; therapy adverse effect; trafficking; treatment adverse effect; wt-loss",Cannabinoid Receptor One-B Arrestin Interactions,,28080,ZRG1,Special Emphasis Panel,,1,47604,
7910347,F32,DE,1,,03/03/2010,03/02/2011,PA-09-210,1F32DE020976-01,,NIDCR:52233;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,MINNEAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"KOPHER, ROSS A;",9411247;,1F32DE020976,03/03/2010,03/02/2011,"21+ years old; Adult; American; Bone Development; Bone Diseases; Bone Formation; Bone Injury; Bone Regeneration; CD34; CD34 gene; Cell Communication and Signaling; Cell Signaling; Cell Therapy; Cells; Craniosynostosis; Derivation; Derivation procedure; Development; Disease; Disorder; ES cell; Engineering; Engineerings; Experimental Models; Experimental Models, Other; Fracture; Fragilitas Ossium; Genetic; HPCA1; Hematopoietic; Human; Human, Adult; Human, General; In Vitro; Intracellular Communication and Signaling; Man (Taxonomy); Man, Modern; Mediating; Medical; Mesenchymal; Mesoderm; Modeling; Models, Experimental; Mother Cells; Osteogenesis; Osteogenesis Imperfecta; Osteoporosis; Pathway interactions; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Reporter; Research Resources; Resources; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Testing; Therapy, Cell; Translating; Translatings; adult human (21+); base; biological signal transduction; bone disorder; bone fracture; bone repair; brittle bone disease; cell type; cell-based therapy; clinical practice; disease/disorder; embryonic stem cell; hESC; human ES cell; human ESC; human embryonic stem cell; in vivo; innovate; innovation; innovative; insight; language translation; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; osteoblast differentiation; osteogenic; osteoprogenitor cell; pathway; public health relevance; repair; repaired; stem cell of embryonic origin; synostosis (cranial)",Embryonic stem cell-derived osteoprogenitor cells for bone formation and repair," Project Narrative  It is estimated that more than 10 million Americans have osteoporosis, and that 5-10% of all fractures are complicated by delayed union or nonunion, thus indicating that diseases of bone formation represent a serious medical issue. While a variety of cell-based therapies have been tested for bone disorders, there are inherent limitations to the types of cells (principally adult mesenchymal or endothelial progenitor cells) that have been used in the existing experimental models. The derivation and characterization of human embryonic stem cells (hESCs) provides a unique and potentially highly significant advance in understanding the mechanisms pertaining to bone regeneration and the management of these conditions.",20976,DSR,NIDR Special Grants Review Committee,,1,52233,
7912304,F32,DK,1,,02/01/2010,01/31/2011,PA-09-210,1F32DK088514-01,,NIDDK:50006;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TUCSON,UNITED STATES,VETERINARY SCIENCES,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"GREEN, ALICE S;",9770766;,1F32DK088514,02/01/2010,01/31/2012,"0-6 weeks old; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 21+ years old; Address; Adult; Animals; Arginine; Arginine, L-Isomer; Beta Cell; Biology; Birth; Blood Pressure, High; Cardiovascular Diseases; Catecholamines; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chemotherapy-Hormones/Steroids; Chronic; Chronic Disease; Chronic Illness; Coupling; D-Glucose; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dysfunction; Endocrine Gland Secretion; Exhibits; Exposure to; Fetal Growth; Fetal Growth Restriction; Fetal Growth Retardation; Fetus; Functional disorder; Gestation; Glucose; Goals; Growth, Fetal; Hormones; Human, Adult; Humulin R; Hyperlipemia; Hyperlipidemia; Hypertension; Hypoxemia; IUGR; Impairment; In Vitro; Incidence; Individual; Infant, Newborn; Infant, Small for Gestational Age; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Intracellular Communication and Signaling; Intrauterine Growth Retardation; L-Arginine; Last Trimester; Lead; Levarterenol; Levonorepinephrine; Life; MODY; Maturity-Onset Diabetes Mellitus; Measures; Medical; Metabolic; Metabolic Diseases; Metabolic Disorder; Mission; Modeling; Molecular; NIDDK; NIDDM; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Newborn Infant; Newborns; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Noradrenaline; Norepinephrine; Novolin R; Operation; Operative Procedures; Operative Surgical Procedures; Ovis; Parturition; Pb element; Perinatal; Physiopathology; Placental Insufficiency; Pregnancy; Pregnancy Trimester, Third; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Risk; Role; Sheep; Signal Transduction; Signal Transduction Systems; Signaling; Small for Gestational Age Infant; Stimulus; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Sympathins; T2D; T2DM; Testing; Therapeutic Hormone; Thesaurismosis; Third Pregnancy Trimester; Training Programs; Trimester, Third; Type 2 diabetes; Type II diabetes; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; adult human (21+); adult onset diabetes; biological signal transduction; cardiovascular disorder; chronic disease/disorder; chronic disorder; cost; design; designing; diabetes; disease risk; disease/disorder; disorder risk; experiment; experimental research; experimental study; fetal; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; hypoxemic; impaired glucose tolerance; improved; in vivo; insulin secretion; intrauterine growth; intrauterine growth restriction; islet; ketosis resistant diabetes; maturity onset diabetes; metabolism disorder; newborn human (0-6 weeks); offspring; oxidation; pathophysiology; prenatal growth disorder; programs; public health medicine (field); public health relevance; research study; small for gestational age; social role; surgery; therapeutic target",Role of catecholamines in beta-cell dysfunction in IUGR fetuses, 7. Project Narrative Intrauterine growth restriction (IUGR) is a significant public health challenge and results in the offspring having increased risk of chronic adulthood diseases like Type 2 Diabetes. Understanding the mechanisms for how conditions during pregnancy influence an individual's later risk for disease is important to developing treatments. Our studies investigate high fetal levels of the hormones catecholamines during IUGR pregnancies as a potential mechanism for some of the problems with insulin secretion that appear later in life and ultimately result in the development of Type 2 Diabetes. ),88514,ZDK1,Special Emphasis Panel,,1,50006,
7810376,F32,ES,1,,02/01/2010,01/31/2011,PA-07-107,1F32ES018039-01,,NIEHS:47210;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,DAVIS,UNITED STATES,ZOOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"MCCOY, MARK ;",9890453;,1F32ES018039,02/01/2010,01/31/2012,"3,4,4'-trichlorocarbanilide; Affect; Animals; Anti-Bacterial Agents; Antibacterial Agents; Antibodies; Arachidonic Acids; Assay; Back; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biosensor; Blood; Blood Pressure; Chemicals; Common Rat Strains; Complex; Detection; Development; Dorsum; Drug Administration, Topical; Environment; Enzymes; Epoxide Hydrases; Epoxide Hydratases; Epoxide hydrolase; Equipment; Human; Human, General; INFLM; Immunoassay; Inflammation; Instrumentation, Other; Laboratories; Literature; Magnetism; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea; Pain; Painful; Peptides; Phage Display; Plants; Plants, General; Production; Rat; Rattus; Reticuloendothelial System, Blood; Role; Sampling; Self Care; Site; Techniques; Time; Topical application; Translating; Translatings; United States; Urinary System, Urine; Urine; Xenobiotic Metabolism; analytical method; anti-bacterial; antibacterial; base; biomarker; cost; cost effective; cross reactivity; experiment; experimental research; experimental study; high throughput analysis; in vivo; inhibitor; inhibitor/antagonist; instrumentation; language translation; magnetic; nano particle; nanoparticle; personal care; polyclonal antibody; portability; public health relevance; research study; scaffold; scaffolding; sensor (biological); small molecule; social role; topical administration; topical drug application; topically applied; trichlorcarban; triclocarban",Development of an Immunoassay for the Detection of Triclocarban,,18039,ZRG1,Special Emphasis Panel,,1,47210,
7808186,F32,GM,1,,03/01/2010,02/28/2011,PA-07-107,1F32GM087069-01A2,,NIGMS:47606;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,GENETICS,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"KELLEY, JOANNA ;",9422695;,1F32GM087069,03/01/2010,02/29/2012,"Address; Africa; African; Age; Agriculture; Alleles; Allelomorphs; Asia; Categories; Chicago; Chromosomes; Chronology; Collaborations; Computer Programs; Computer software; Conflict; Conflict (Psychology); DNA Recombination; DNA Resequencing; DNA recombination (naturally occurring); Data; Data Set; Dataset; Demography; Diathesis; Disease; Disease susceptibility; Disorder; Environment; Ethnic group; Europe; European; Event; Evolution; Evolution, Molecular; Eye; Eye Color; Eyeball; Faculty; Frequencies (time pattern); Frequency; Funding; GWAS; Genes; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic Population Study; Genetic Recombination; Genetic Research; Genetic analyses; Genetic defect; Genetics, Population; Genome; Genomics; Genotype; Geography; Goals; History; Human; Human Genome Project; Human, General; Ice; Individual; Institution; Internet; Investigators; Learning; Length; Man (Taxonomy); Man, Modern; Mentors; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Evolution; Mollies; Mutation; Organism; Pattern; Performance; Phenotype; Phylogenetic Analysis; Phylogenetics; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Genetics; Population Studies / Demography; Pressure; Pressure- physical agent; Prevalence; Proxy; Recombination; Recombination, Genetic; Recording of previous events; Research; Research Personnel; Research Resources; Research Training; Researchers; Resequencing; Resources; Role; Sampling; Scanning; Science of Statistics; Shapes; Site; Software; Statistics; Techniques; Testing; Time; Training; Universities; Variant; Variation; WWW; Work; agricultural; base; career; computer program/software; disease/disorder; disease/disorder proneness/risk; experience; falls; genetic analysis; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human population genetics; insight; interest; liability to disease; living system; markov model; novel; polymorphism; post-doctoral training; postdoctoral training; pressure; skills; social role; statistics; tool; web; whole genome association studies; whole genome association study; world wide web",Dating selection pressures in recent human evolution,,87069,ZRG1,Special Emphasis Panel,A2,1,47606,
7804866,F32,GM,1,,01/27/2010,01/26/2011,PA-07-107,1F32GM090362-01,,NIGMS:45590;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"MCMENAMIN, SARAH KELLY;",9820901;,1F32GM090362,01/27/2010,01/26/2013,"21+ years old; Adult; Affect; Amphibia; Amphibians; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Metamorphosis; Brachydanio rerio; Cancers; Cell Communication and Signaling; Cell Function; Cell Lineage; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Danio rerio; Defect; Development; Developmental Biology; Disease; Disorder; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endocrine; Fertility/Fertilization; Fertilization; Fishes; Future; Genes; Genetic; Genetic Screening; Goals; Health; Hormonal; Human; Human, Adult; Human, General; Insertional Mutagenesis; Intracellular Communication and Signaling; Link; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metamorphosis, Biological; Molecular; Morphogenesis; Mother Cells; Mutagenesis, Insertional; Neonatal; Outcome; Pathway interactions; Pattern; Pigments; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Recruitment Activity; Research; Research Resources; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; Subcellular Process; Syndrome; System; System, LOINC Axis 4; Testing; Thyroid Gland Hormone; Thyroid Hormones; Time; Training; Transgenic Organisms; Translating; Translatings; Vertebrate Animals; Vertebrates; Work; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); base; biological signal transduction; cell behavior; cell type; disease/disorder; experiment; experimental research; experimental study; fetal; insight; language translation; malignancy; melanocyte; metamorphosis; mutant; neoplasm/cancer; novel; pathway; precursor cell; programs; recruit; research study; self-renewal; social role; stem; stem cell population; trait; transgenic; vector; vertebrata",1.19Hormonal controls of zebrafish post-embryonic melanocyte development,,90362,ZRG1,Special Emphasis Panel,,1,45590,
7806280,F32,GM,1,,02/01/2010,01/31/2011,,1F32GM090551-01,,NIGMS:47606;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"FEESER, ELIZABETH A.;",9838872;,1F32GM090551,02/01/2010,01/31/2013,"ATPase, Actin-Activated; Actins; Actomyosin; Adenosine Triphosphatase, Myosin; Affinity; Automobile Driving; Binding; Binding (Molecular Function); Biochemical; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell membrane; Cell physiology; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Deafness; Defect; Drivings, Automobile; Endothelium; Family; Family member; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Head; Human; Human, General; INFLM; Inflammation; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Isoforms; Kinetic; Kinetics; Link; Lipids; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane; Methods and Techniques; Methods, Other; Mice; Molecular; Molecular Interaction; Motility; Motility, Cellular; Motor; Murine; Mus; Mutation; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; PH Domain; PIP2; Phosphatidyl Inositol; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphoinositides; Physiologic; Physiological; Plasma Membrane; Play; Pleckstrin-Homology Domain; Predisposition; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; PtIns 4,5-P2; PtdIns; PtdInsP2; Role; Sampling; Specificity; Subcellular Process; Surface; Susceptibility; System; System, LOINC Axis 4; Tail; Techniques; base; cell motility; driving; gene product; genome mutation; insight; intracellular skeleton; kidney infection; membrane structure; myosin ATP phosphohydrolase (actin translocating); plasmalemma; public health relevance; reconstitute; reconstitution; social role",Myosin-1 interactions with membranes,,90551,ZRG1,Special Emphasis Panel,,1,47606,
7806005,F32,GM,1,,03/01/2010,02/28/2011,,1F32GM090557-01,,NIGMS:47750;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"PAABY, ANNALISE BLOSS BLOSS;",9851119;,1F32GM090557,03/01/2010,02/28/2013,"Affect; Alleles; Allelomorphs; Architecture; Biological; Biological Models; Biology; Buffers; C elegans; C. elegans genome; C.elegans; Caenorhabditis elegans; Complex; Development; Developmental Process; Disease; Disorder; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Engineering / Architecture; Event; Future; Gene Components; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic Diversity; Genetic Variation; Genetic defect; Genie; Genome; Genomics; Genotype; Goals; High Throughput Assay; History; Investigation; Laboratory Study; Maps; Medicine; Model System; Modeling; Models, Biologic; Mutation; Nematoda; Nematodes; Nucleotides; Partner in relationship; Phenotype; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; QTL; Quantitative Trait Loci; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Recombinants; Recording of previous events; Research; Research Resources; Resources; Science of Medicine; Sequence-Specific Posttranscriptional Gene Silencing; System; System, LOINC Axis 4; Translations; Variant; Variation; Variation (Genetics); Work; allelic variant; base; biological systems; developmental genetics; disease/disorder; experiment; experimental research; experimental study; fundamental research; genetic determinant; genetic manipulation; genetic variant; genome mutation; genome, C elegans; genome, C. elegans; genome, C.elegans; genome, Caenorhabditis elegans; high throughput screening; human disease; insight; interest; knock-down; mate; novel; prevent; preventing; public health research; research study; roundworm; trait",Discovering buffered developmental networks underlying C. elegans embryogenesis,,90557,ZRG1,Special Emphasis Panel,,1,47750,
7805971,F32,GM,1,,02/01/2010,01/31/2011,PA-07-107,1F32GM090671-01,,NIGMS:47606;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,BIOCHEMISTRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"ZOLTOWSKI, BRIAN DAVID;",9843624;,1F32GM090671,02/01/2010,01/31/2012,"AHR; ARNT; ARNT protein; Activation, Gene; Active Sites; Affect; Affinity; Agonist; Ah receptor nuclear translocator protein; AhR nuclear translocator; Architecture; Aryl Hydrocarbon Receptor; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cessation of life; Combining Site; Complex; Crossmatching, Tissue; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cues; DNA; Death; Deoxyribonucleic Acid; Development; Disease Progression; Elements; Endocrine system; Endocrine system (all sites); Endocrine/Metabolic Organ System; Engineering / Architecture; Equilibrium; Estrogen Receptors; Family; Gene Action Regulation; Gene Activation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Generations; Genetic Transcription; Goals; HIF-1beta protein; Histocompatibility Testing; Hormonal System; Hypoxia; Hypoxic; INFLM; In Vitro; Inflammation; Intracellular Communication and Signaling; Kinetic; Kinetics; Libraries; Ligand Binding; Ligands; Link; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Measurement; Mediating; Metabolic/Endocrine Body System; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Motion; Nuclear Translocator; Output; Oxygen Deficiency; Pathway interactions; Population; Principal Component Analyses; Principal Component Analysis; Proteins; RNA Expression; Reactive Site; Receptor Activation; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Regulation; Relative; Relative (related person); Reporting; Response Elements; Role; Sexual Development; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Sites, Active; Solutions; Specificity; Stress; Structure; System; System, LOINC Axis 4; TCDD Receptors; Techniques; Therapeutic Uses; Tissue Crossmatchings; Tissue Typing; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Up-Regulation; X Ray Crystallographies; X-Ray Crystallography; Xenobiotics; ahr ligand; anticancer therapy; aryl hydrocarbon nuclear translocator; aryl hydrocarbon receptor ligand; atheromatosis; atherosclerotic vascular disease; balance; balance function; base; biological signal transduction; cancer progression; cancer therapy; cellular development; conformation; conformational state; dimer; dioxin receptor, nuclear translocator; endocrine gland/system; gene product; histocompatibility typing; human disease; hypoxia-inducible factor 1 beta; in vivo; malignancy; neoplasm progression; neoplasm/cancer; neoplastic progression; pathway; protein complex; protein protein interaction; public health relevance; response; scaffold; scaffolding; sex development; small molecule; social role; transcription factor; tumor progression",Structural Dynamics of Pas Domain Containing Transcription Factors,,90671,ZRG1,Special Emphasis Panel,,1,47606,
7810178,F32,HD,1,,02/01/2010,01/30/2011,PA-07-107,1F32HD059318-01A1,,NICHD:49731;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CHAPEL HILL,UNITED STATES,PSYCHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"CHRIST, SHARON LOUISE;",9302082;,1F32HD059318,02/01/2010,01/31/2012,"0-11 years old; Accounting; Address; Adolescent; Adolescent Development; Adolescent Youth; Adopted; Affect; Affective; Aggression; Aggressive behavior; Anxiety; Area; Athletic; Attention; Behavior; Behavioral; Care Givers; Caregivers; Child; Child Abuse; Child Abuse and Neglect; Child Development; Child Youth; Child health care; Childhood Abuse; Childhood maltreatment; Children (0-21); Communities; Complement; Complement Proteins; Complex; Data; Depression; Development; Dimensions; Disease; Disorder; Equation; Family; Female; Goals; Health; Health, Child; Human, Child; Incidence; Infant and Child Development; Institution; Intervention; Intervention Strategies; Investigation; Investigators; Learning; Life; Life Cycle; Life Cycle Stages; Measurement; Measures; Mental Depression; Mental Health; Mental Hygiene; Mentorship; Methods; Methods and Techniques; Methods, Other; Modeling; NICHD; NRSA; National Institute of Child Health and Human Development; National Research Service Awards; Neurologic; Neurological; Personal Satisfaction; Population; Programs (PT); Programs [Publication Type]; Psyche structure; Psychological Health; Public Health; R01 Mechanism; R01 Program; RPG; Religion and Spirituality; Reporter; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Sampling; Schools; Severities; Sum; Supervision; Survey Instrument; Surveys; Techniques; Testing; Time; Training; Typology; Violence; Withdrawal; Youth; Youth 10-21; abuse neglect; child maltreatment; child protection services; child protective service; children; cognitive function; cost; design; designing; disease/disorder; improved; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; life course; male; maltreated children; maltreatment; meetings; mental; mistreatment; model development; neglect and abuse; physical conditioning; population based; programs; psychologic; psychological; public health medicine (field); public health research; religious; resilience; response; skills; social; social organization; theories; time use; violent; violent behavior; well-being; youngster",Evaluating Maltreatment Effects on Adolescent Well-being Using Advanced Modeling,,59318,ZRG1,Special Emphasis Panel,A1,1,49731,
7809053,F32,HD,1,,02/01/2010,01/31/2011,,1F32HD061177-01A1,,NICHD:50474;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,ATLANTA,UNITED STATES,MISCELLANEOUS,05,837322494,US,GA,303023999,GEORGIA STATE UNIVERSITY,"SAYERS, KENNETH ;",9433860;,1F32HD061177,02/01/2010,01/31/2012,"Aging; Animals; Area; Chimp; Chimpanzee; Cognition; Data; Decision Making; Disease; Disorder; Distant; Economics; Episodic memory; Episodic memory, function; Event; Evolution; Exhibits; Food; Gestures; Goals; Human; Human, General; Individual; Injury; Language; Location; Mammals, Primates; Man (Taxonomy); Man, Modern; Manuals; Memory; Modeling; Movement; Pan; Pan Genus; Pan Species; Persons; Primates; Protocol; Protocols documentation; Recognition (Psychology); Recovery; Recruitment Activity; Research; Research Design; Research Resources; Resources; Rewards; Risk; Senescence; Simulate; Speech; Study Type; System; System, LOINC Axis 4; Testing; Time; Training; Universities; Visit; Work; base; body movement; disease/disorder; experiment; experimental research; experimental study; food resource; long term memory; memory recall; memory recognition; meter; preference; prospective; recruit; research study; senescent; study design; theories; vocalization","Chimpanze spatial cognition, foraging theory, and the question of episodic memory",,61177,ZRG1,Special Emphasis Panel,A1,1,50474,
7806790,F32,HD,1,,02/01/2010,01/31/2013,,1F32HD061180-01A1,,NICHD:47606;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CAMBRIDGE,UNITED STATES,OTHER BASIC SCIENCES,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"EDDY, MARIANNA DOROTHY;",8559088;,1F32HD061180,02/01/2010,01/31/2011,"0-11 years old; 10 year old; 21+ years old; 5 year old; Adult; Age; Age Group Unspecified; Area; Attenuated; Behavioral; Bilateral; Brain; Child; Child Youth; Children (0-21); Development; Dyslexia; Encephalon; Encephalons; Event-Related Potentials; Functional Magnetic Resonance Imaging; Goals; Human, Adult; Human, Child; Image; Impairment; Influentials; Lead; Learning; Left; Link; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Maps; Masks; Measures; Method LOINC Axis 6; Methodology; Modeling; Nature; Nervous; Nervous System, Brain; Orthography; Pattern; Pb element; Perception; Population; Population Study; Predisposition; Process; Public Health; Reader; Reading; Research; Resolution; Risk; Role; Route; Semantic; Semantics; Series; Sound; Sound - physical agent; Staging; Susceptibility; System; System, LOINC Axis 4; Time; Training; Visual; Word Blindness; Word Processing; Word Processings; Work; adult human (21+); adult youth; age group; children; college; event related potential; experiment; experimental research; experimental study; extrastriate visual cortex; fMRI; five year old; heavy metal Pb; heavy metal lead; imaging; language processing; neural; neuroimaging; new approaches; novel; novel approaches; novel strategies; novel strategy; orthographic; orthographical; phonological; phonology; public health medicine (field); relating to nervous system; research study; skills; social role; sound; ten year old; vision development; visual development; visual process; visual processing; visual system development; young adult; youngster",Neural correlates of orthographic and phonological processing in dyslexia,,61180,ZRG1,Special Emphasis Panel,A1,1,47606,
7801872,F32,HD,1,,02/01/2010,01/31/2011,PA-07-107,1F32HD063255-01,,NICHD:50090;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LOS ANGELES,UNITED STATES,PSYCHOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"SAXBE, DARBY E.;",9816539;,1F32HD063255,02/01/2010,01/31/2013,"12-20 years old; Adolescence; Adolescent; Adolescent Youth; Affective; Age; Anterior; Anxiety; Area; Behavior; Brain; Brain region; Care Givers; Caregivers; Causality; Central Lobe; Cognitive; Computers; Conflict; Conflict (Psychology); Data; Depression; Development; Diaries; Diaries (PT); Diaries [Publication Type]; Distress; Emotional Depression; Encephalon; Encephalons; Environment; Etiology; Exclusion; Exposure to; Family; Feeling; Functional Magnetic Resonance Imaging; Housing; Insula; Insula of Reil; Island of Reil; Label; Lead; Length of Life; Life; Link; Longevity; Longitudinal Studies; MRI, Functional; Magnetic Resonance Imaging, Functional; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; Models, Theoretic; Mortality; Mortality Vital Statistics; Nervous; Nervous System, Brain; Pain; Painful; Participant; Pathway interactions; Patient Self-Report; Pb element; Personal Satisfaction; Prefrontal Cortex; Process; Protocol; Protocols documentation; Psyche structure; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychopathology; Questionnaires; Recruitment Activity; Regulation; Reporter; Research; Risk; Risk-Taking; Sampling; Self-Report; Social Behavior; Social Functioning; Social Interaction; Social isolation; Staging; Symptoms; Symptoms of depression; Testing; Theoretical model; Unspecified Mental Disorder; Yang; Youth; Youth 10-21; abnormal psychology; adolescence (12-20); base; brain research; depressive; depressive symptoms; design; designing; diaries; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experience; externalizing behavior; fMRI; feelings; heavy metal Pb; heavy metal lead; intervention development; juvenile; juvenile human; life span; lifespan; long-term study; mental; mental illness; neural; neuroimaging; pathway; peer; physical conditioning; psychologic; psychological; psychological disorder; public health relevance; recruit; relating to nervous system; response; social; social integration; social neuroscience; sociobehavior; sociobehavioral; teenage; therapy development; treatment development; well-being",Neural correlates of social exclusion among youth exposed to family conflict,,63255,ZRG1,Special Emphasis Panel,,1,50090,
7808357,F32,HL,1,,02/01/2010,01/31/2011,,1F32HL094037-01A2,,NHLBI:50054;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"CHOI, JASON CHEOL;",9299145;,1F32HL094037,02/01/2010,01/31/2013,"Actins; Affect; Amino Acids; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Circulation; Bloodstream; Body Tissues; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiomyopathies; Cell Nucleus; Cells; Cellular Matrix; Circulation; Clinical; Co-Immunoprecipitations; Complex; Cytoskeletal System; Cytoskeleton; Data; Defect; Development; Digitin; Digitonin; Disease; Disorder; EC 2.7.2-; ERK2; ERT1; Emery-Dreifuss Muscular Dystrophy; Emery-Dreifuss Muscular Dystrophy 2; Emery-Dreifuss Syndrome; Energy Transfer; Ensure; Extracellular Signal-Regulated Kinases; FRET; Fluorescence; Fluorescence Microscopy; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; GFAC; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hauptmann-Thannhauser Muscular Dystrophy; Heart; Heart myocyte; Hereditary Disease; Human; Human, General; Import, Nuclear; In Vitro; Inflammatory; Integral Membrane Protein; Intermediate Filaments; Intrinsic Membrane Protein; JNK; JNK1; JNK1A2; JNK21B1/2; Knock-in; Knock-in Mouse; Knowledge; Lamin A; Lamin Type A; Lead; Life; Ligand Binding Protein; Link; MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK1; MAPK1 gene; MAPK2; MAPK8; MAPK8 gene; MTGN; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitogen-Activated Protein Kinases; Mitogens; Molecular; Molecular Disease; Molecular Interaction; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Muscular Dystrophy, Emery-Dreifuss; Muscular Dystrophy, Emery-Dreifuss Type; Muscular Dystrophy, Emery-Dreifuss, Autosomal Dominant; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes, Cardiac; N-terminal; NH2-terminal; Nuclear Envelope; Nuclear Import; Nuclear Inner Membrane; Nuclear Lamina; Nuclear Membrane; Nuclear Structure; Nuclear Translocation; Nucleus; P41MAPK; P42MAPK; PRKM1; PRKM2; PRKM8; Pathogenesis; Pathway interactions; Patients; Pb element; Photobleaching; Point Mutation; Protein Kinase Interaction; Proteins; RNA, Small Interfering; SAPK1; Scapuloilioperoneal Atrophy with Cardiopathy; Signal Pathway; Skeletal Muscle Tissue; Skeletal muscle structure; Small Interfering RNA; Stimulus; Stress; Surface; Surface Proteins; Symptoms; Techniques; Testing; Therapeutic Intervention; Time; Tissues; Transmembrane Protein; Two Hybrid; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; aminoacid; base; beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl) O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4; biological adaptation to stress; cardiac muscle; cardiomyocyte; cytokine; disease/disorder; effective therapy; experiment; experimental research; experimental study; extracellular; gene product; genetic disorder; genome mutation; heart muscle; heavy metal Pb; heavy metal lead; hereditary disorder; intervention therapy; intracellular skeleton; mouse model; muscular dystrophy mouse model; mutant; myocardium disorder; overexpression; pathway; prevent; preventing; reaction; crisis; reconstitute; reconstitution; research study; response; siRNA; stress response; stress; reaction; treatment strategy; yeast two hybrid system",Molecular and Cellular Pathogenesis of Emery-Dreifuss Muscular Dystrophy,,94037,ZRG1,Special Emphasis Panel,A2,1,50054,
7808211,F32,HL,1,,02/01/2010,01/31/2011,,1F32HL097598-01A1,,NHLBI:52154;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,PATHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GOROVOY, MATVEY ;",8883285;,1F32HL097598,02/01/2010,01/31/2012,"Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; ApoE Receptor; Applications Grants; Arthritis; Attenuated; Autoimmune; Autoimmune Process; Autoregulation; Biodistribution; Biological; Blood; Blood Cells; Blood Circulation; Blood Neutrophil; Blood Plasma; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bloodstream; Body Tissues; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell surface; Cells; Circulation; Coupled; Data; Development; Disease; Disintegrins; Disorder; Dropsy; Dysfunction; Edema; Endocytosis; Endotoxins; Esteroproteases; Exhibits; Functional disorder; Gamma interferon; Gene Family; Goals; Grant Proposals; Grants, Applications; Half-Life; Half-Lifes; Heterophil Granulocyte; Homeostasis; Human; Human, General; Hydrops; IFN-Gamma; IFN-g; IFNG; INFLM; In Vitro; Infection; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Injection of therapeutic agent; Injections; Injury; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Intracellular Communication and Signaling; LDL; LDL-Receptor Related Protein 1; LPS; Laboratories; Ligands; Lipopolysaccharides; Lipoprotein LDL Receptors; Lipoproteins; Lipoproteins, LDL; Low Density Lipoprotein Receptor; Low Density Lipoprotein Receptor-Related Protein; Low-Density Lipoproteins; Low-Density-Lipoprotein Receptor-Related Protein-1; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Molecular; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organ; Pathogenesis; Pathway interactions; Peptidases; Peptide Hydrolases; Peripheral Blood Cell; Peripheral nerve injury; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Plasma; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteases; Proteinases; Proteolytic Enzymes; R01 Mechanism; R01 Program; RPG; Receptor Gene; Receptor Protein; Receptor, Apo E; Receptor, Apolipoprotein E; Receptors, LDL; Regulation; Reporting; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Rodent Model; Role; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stimulus; Surface Proteins; Testing; Time; Tissues; Wild Type Mouse; alpha-2-Macroglobulin Receptor; alpha2-Macroglobulin Signaling Receptor; arthritic; base; beta-Lipoproteins; biological signal transduction; biomarker; cardiovascular disorder; cytokine; disease/disorder; extracellular; in vivo; lFN-Gamma; macrophage; malignancy; member; membrane structure; metalloproteinase (general); mouse model; neoplasm/cancer; neutrophil; novel; pathophysiology; pathway; protein function; receptor; receptor mediated endocytosis; response; social role",Shed LDL Receptor Related Protein 1 (sLRP-1) and Inflammation,,97598,ZRG1,Special Emphasis Panel,A1,1,52154,
7801920,F32,HL,1,,03/01/2010,02/28/2011,,1F32HL099027-01,,NHLBI:47606;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLOTTESVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"JUNCADELLA, IGNACIO JAVIER;",9817411;,1F32HL099027,03/01/2010,02/29/2012,"Abscission; Address; Affect; Alveolar; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Apoptotic; Architecture; Assay; Autoantigens; Autologous Antigens; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Biology; CSIF; CSIF-10; Cell Death, Programmed; Cell Nucleus; Cells; Chronic; Coloring Agents; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Defect; Development; Dinoprostone; Disease; Disorder; Dyes; Engineering; Engineering / Architecture; Engineerings; Environment; Epithelial; Epithelial Cells; Excision; Extirpation; Generations; Homeostasis; Human Figure; Human body; IL-10; IL10; IL10A; INFLM; Immune response; Immune system; In Vitro; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interleukin 10 Precursor; Interleukin-10; Link; Lung; Maintenance; Maintenances; Mammals, Mice; Measures; Mediating; Mice; Mice, Transgenic; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; Nucleus; PGE2; PGE2 alpha; PGE2alpha; Physiological Homeostasis; Physiology; Play; Poisons; Process; Production; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Proteins; RNA, Small Interfering; Regulatory T-Lymphocyte; Removal; Respiratory System, Lung; Respiratory physiology; Role; Self-Antigens; Small G-Proteins; Small GTPases; Small Interfering RNA; Staging; Surgical Removal; System; System, LOINC Axis 4; T-Lymphocyte, Regulatory; Testing; Tetracycline Antibiotic; Tetracyclines; Toxic Chemical; Toxic Substance; Transgenic Mice; base; body system, allergic/immunologic; cancer type; design; designing; disease/disorder; gene product; host response; immunoresponse; in vivo; lung function; organ system, allergic/immunologic; poison; prevent; preventing; pulmonary; resection; respiratory function; response; siRNA; social role; toxic compound","Engulfment of airway epithelial cells, lung homeostasis and inflammation",,99027,ZRG1,Special Emphasis Panel,,1,47606,
7800102,F32,HL,1,,03/01/2010,02/28/2011,,1F32HL099029-01,,NHLBI:47210;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,PHYSIOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"SCRUGGS, SARAH ;",9819181;,1F32HL099029,03/01/2010,02/28/2013,"1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; 3'5'-cyclic ester of AMP; APF-1; ATP-Dependent Proteolysis Factor 1; Acute; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adrenergic Agents; Adrenergic Drugs; Adrenergics; Adult; Affect; Affinity Chromatography; Animals; Aortic Stenosis; Aortic Valve Stenosis; Attenuated; Autoregulation; Biochemical; Biological; Blood Pressure, High; Bypass; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiomyopathy, Hypertrophic Obstructive; Cardiovascular Diseases; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cell membrane; Charge; Chromatography, Affinity; Chronic; Complex; Critical Paths; Critical Pathways; Cyclic AMP; Cytoplasmic Membrane; Degradation Pathway; Degradative Pathway; Depressed mood; Diamond; Disease; Disease Progression; Disorder; Dobutamine; EC 2.7; Face; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Growth; HMG-20; HTRPY; Health; Heart; Heart Hypertrophy; Heart failure; Heart myocyte; Heterogeneity; High Mobility Protein 20; Histology; Homeostasis; Human, Adult; Hypertension; Hypertrophic Cardiomyopathy; Hypertrophy; In Situ; Intracellular Communication and Signaling; Kinases; Kinetic; Kinetics; Left; Left Ventricles; Left ventricular structure; Light; Macropain; Macroxyproteinase; Mammals, Mice; Maps; Measures; Methods; Mice; Mice, Transgenic; Modeling; Monitor; Morphology; Multicatalytic Proteinase; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Mutation; Myocytes; Myocytes, Cardiac; Names; Neonatal; Particulate; Pathogenesis; Pathologic; Pathway interactions; Patients; Pattern; Peptide Biosynthesis, Ribosomal; Peptides; Phase; Phenotype; Phosphorylation; Phosphotransferases; Photoradiation; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pressure; Pressure- physical agent; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Synthesis, Ribosomal; Protein Turnover; Proteins; Proteolytic Regulation; Proteomics; Proteosome; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reaction; Receptor Protein; Recruitment Activity; Regulation; Regulation of Proteolysis; Relative; Relative (related person); Role; Sarcomeres; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stress; System; System, LOINC Axis 4; Systolic Pressure; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Time; Tissue Growth; Transgenic Mice; Transphosphorylases; Ubiquitin; United States; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Ventricular; Ventricular Function; adenosine 3'5' monophosphate; adrenergic; adult human (21+); affinity purification; biological signal transduction; cAMP; cardiac failure; cardiac hypertrophy; cardiomyocyte; cardiovascular disorder; combat; constriction; depressed; design; designing; disease/disorder; experiment; experimental research; experimental study; facial; gene product; genome mutation; hyperpiesia; hyperpiesis; hypertensive disease; hypertrophic myocardiopathy; in vivo; insight; knock-down; mouse model; multicatalytic endopeptidase complex; novel; ontogeny; pathway; plasmalemma; pressure; prevent; preventing; protein degradation; protein synthesis; receptor; recruit; research study; sadness; social role; stoichiometry; transgene expression",Acute and Chronic Regulation of 20S Proteasome Function by cAMP-Dependent Kinase,,99029,ZRG1,Special Emphasis Panel,,1,47210,
7806144,F32,HL,1,,02/01/2010,01/31/2011,,1F32HL099070-01,,NHLBI:57686;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"CHO, JOSALYN L;",9836536;,1F32HL099070,02/01/2010,08/31/2011,"APC; Acute; Address; Allografting; Antigen-Presenting Cells; Antigens, LD; Binding; Binding (Molecular Function); Bronchioalveolar Lavage; Bronchiolitis Obliterans; Bronchiolitis, Exudative; Bronchiolitis, Proliferative; Bronchoalveolar Lavage; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; Cell-Mediated Cytolysis; Cell-Mediated Lympholysis; Cells; Cellular Cytotoxicity; Chronic; Cicatrix; Clinical, Transplantation, Organ; Complex; Cytotoxicity, Immunologic; D-Galactoside-Binding Lectin; Data; Dendritic Cells; Development; Equilibrium; Expression Profiling; Expression Signature; Galactose Binding Lectin; Galaptins; Galectins; Generations; Graft Material; Grafting Procedure; Grafting, Lung; HL-A Antigens; HLA Antigens; Human; Human Leukocyte Antigens; Human, General; Immune; Immune Globulins; Immune system; Immunoglobulins; Immunoglobulins / Antibodies; Immunologic Accessory Cells; Immunologic, Immunochemical; Immunologics; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Injury; Investigation; LYT3; Laboratories; Lavage, Bronchopulmonary; Lectins, S-Type; Leukocyte Antigens; Ligands; Lung; Lung Lavage; Lung Transplantation; Lung diseases; Lymphocyte; Lymphocyte Cytotoxicity; Lymphocyte antigen; Lymphocytic; Lymphocytotoxicity; Lytotoxicity; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monocytes / Macrophages / APC; Mortality; Mortality Vital Statistics; Mucins; Mucus Glycoprotein; Murine; Mus; Natural immunosuppression; Operation; Operative Procedures; Operative Surgical Procedures; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Pathway interactions; Patients; Pattern; Play; Protein Family; Proteins; Pulmonary Diseases; Pulmonary Disorder; Recruitment Activity; Regulation; Regulatory Protein; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Scars; Solid; Staging; Surface; Surgical; Surgical Interventions; Surgical Procedure; T-Cell Proliferation; T-Cells; T-Lymphocyte; T8 Cells; T8 Lymphocytes; Techniques; Th-1 Cell; Th1 Cells; Therapeutic; Thymus-Dependent Lymphocytes; Trachea; Trachea Proper; Transplantation; Transplantation Surgery; Transplantation Tolerance; Transplanted tissue; Type 1 Helper Cell; Veiled Cells; accessory cell; allograft rejection; animal data; balance; balance function; beta-D-Galactosyl-Specific Lectin; beta-Galactoside Binding Lectin; body system, allergic/immunologic; bronchopulmonary lavage therapy; cell mediated cytotoxicity; cell type; cytokine; cytolysin; cytotoxic serine protease B; cytotoxicity; effective therapy; experiment; experimental research; experimental study; fragmentin 2; gene product; genetic regulatory protein; granzyme B; human disease; immunosuppression; improved; in vivo; insight; lung allograft; lung disorder; lung injury; lymph cell; lymphocyte differentiation antigen; lymphocyte pore-forming protein; molecuar profile; molecular signature; mouse model; new diagnostics; next generation diagnostics; novel; novel diagnostics; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; pathway; perforin; peripheral blood; pulmonary; recruit; regulatory gene product; research study; response; social role; surgery; therapeutic target; thymus derived lymphocyte; transplant; windpipe",The role of T cell immunoglobulin and mucin domain 3 in lung transplantation,,99070,ZRG1,Special Emphasis Panel,,1,57686,
7804086,F32,HL,1,,02/01/2010,01/31/2011,PA-07-107,1F32HL099140-01,,NHLBI:47606;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"HUTCHENS, MARTHA A.;",9842912;,1F32HL099140,02/01/2010,01/31/2012,"0-11 years old; Acute Pulmonary Injury; Affect; Agonist; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antimorphic mutation; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoimmune Diseases; Bacterial Infections; Biosynthetic Proteins; Blood; Blood Cells; Blood Poisoning; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; CellLine; Cells; Child; Child Youth; Children (0-21); Circulatory Collapse; Cues; Cultured Cells; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Endotoxic Shock; Gene Expression; Genes; Heart failure; Human, Child; IL-1; IL-1 beta; IL-1-b; IL-18 receptor; IL1; IL1 Receptors; IL1-Beta; IL1B Protein; IL1F2; INFLM; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Injury; Innovative Therapy; Interleukin 1, Beta Proprotein; Interleukin 1beta; Interleukin I; Interleukin-1; Interleukin-1 Receptors; Interleukin-1 beta; Interleukins; Intracellular Communication and Signaling; LPS; Laboratories; Ligands; Lipopolysaccharides; Lung Injury, Acute; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Mammalian Cell; Mammals, Mice; Maps; Mice; Modeling; Molecular; Mortality; Mortality Vital Statistics; Murine; Mus; Myelogenous; Myeloid; Natural Immunity; Nuclear; Nucleus; Organ; Organ System; Organ System, Cardiovascular; Pathway interactions; Peripheral Blood Cell; Plant Roots; Preclinical Testing; Preinterleukin 1 Beta; Prevention; Production; Proteins; Reaction; Reagent; Receptor Protein; Receptors, IL-1; Receptors, Interleukin-1; Recombinant Proteins; Recombinants; Reticuloendothelial System, Blood; Role; Runaway; Sepsis; Septic Shock; Septicemia; Series; Shock; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Stress; System; System, LOINC Axis 4; T Helper Factor; TLR protein; TLR3; TLR3 gene; TLR4; TLR4 gene; TOLL; Testing; Therapeutic Agents; Therapy, Innovative; Toll-like receptors; Transducers; Transfection; Vascular, Heart; Work; acute lung injury; atheromatosis; atherosclerotic vascular disease; autoimmune disorder; bacterial disease; biological signal transduction; bloodstream infection; body system; cardiac failure; children; circulatory shock; circulatory system; cultured cell line; design; designing; disease/disorder; gene product; hToll; host response; immunoresponse; in vivo; inhibitor; inhibitor/antagonist; insight; interleukin-18 receptor; lymphocyte activating factor; macrophage; microbial; model organism; mouse model; mutant; novel; overexpression; pathway; receptor; root; septicaemia; social role; transcription factor; unspecified interleukin; youngster",Suppression of Inflammation by Intracellular Targeting of MyD88,,99140,ZRG1,Special Emphasis Panel,,1,47606,
7806875,F32,HL,1,,01/27/2010,01/26/2011,PA-07-107,1F32HL099148-01,,NHLBI:48806;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEWARK,UNITED STATES,ANATOMY/CELL BIOLOGY,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"DEL RE, DOMINIC ;",9827281;,1F32HL099148,01/27/2010,10/26/2011,"Ablation; Address; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Biochemical; Blood Pressure, High; Cardiac; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cause of Death; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cellular Expansion; Cellular Growth; Cessation of life; Chronic; Country; Data; Death; Development; Dysfunction; EC 2.7; Echocardiogram; Echocardiography; Enzymes; FLR; Failure (biologic function); Family; Fibroblasts; Fibrosis; Functional disorder; Generalized Growth; Growth; Heart; Heart Hypertrophy; Heart failure; Heart myocyte; Histology; Hypertension; Injury; Intracellular Communication and Signaling; Investigation; Ischemia-Reperfusion Injury; Isoforms; Kinases; Knockout Mice; Knowledge; Laboratories; Lead; Mammals, Mice; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular; Molecular Interaction; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardium; Myocytes; Myocytes, Cardiac; Null Mouse; Organ; Pb element; Phenotype; Phosphotransferases; Physiopathology; Play; Pressure; Pressure- physical agent; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Regulation; Reperfusion Damage; Reperfusion Injury; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sterility; Stress; System; System, LOINC Axis 4; Testing; Tissue Growth; Transgenic Mice; Transphosphorylases; Transthoracic Echocardiography; Tumor Suppressor Proteins; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; base; biological signal transduction; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiac muscle; cardiomyocyte; cell growth; cell type; constriction; coronary attack; coronary infarct; coronary infarction; cytokine; failure; heart attack; heart function; heart infarct; heart infarction; heart muscle; heart sonography; heavy metal Pb; heavy metal lead; hemodynamics; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vivo; mouse model; mutant; ontogeny; pathophysiology; pressure; prevent; preventing; response; social role; sound measurement; sterile; tumor suppressor","Rassf1A signaling in cardiac hypertrophy, fibrosis and failure",,99148,ZRG1,Special Emphasis Panel,,1,48806,
7807261,F32,HL,1,,01/11/2010,01/10/2011,PA-07-107,1F32HL099172-01,,NHLBI:54854;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,SURGERY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"XU, CHUN ;",8876285;,1F32HL099172,01/11/2010,01/10/2012,"Affect; American; Anatomic; Anatomical Sciences; Anatomy; Bicuspid Valve; Cardiac infarction; Chronic; Custom; Devices; Dilatation; Dilatation - action; Dysfunction; Elements; FLR; Failure (biologic function); Functional disorder; Heterogeneity; Image; LV remodeling; Laboratories; Lead; Left Ventricles; Left Ventricular Remodeling; Left ventricular structure; Length of Life; Longevity; Mechanics; Methods and Techniques; Methods, Other; Mitral Incompetence; Mitral Insufficiency; Mitral Regurgitation; Mitral Valve; Mitral Valve Incompetence; Mitral Valve Insufficiency; Mitral Valve Regurgitation; Modeling; Myocardial Infarct; Myocardial Infarction; Myocardial Revascularization; Operation; Operative Procedures; Operative Surgical Procedures; Papillary; Patients; Pattern; Pb element; Physiopathology; Reporting; Resolution; Retrospective Studies; Science of Anatomy; Shapes; Stress; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Testing; Ventricle Remodelings, Left; Ventricular; Work; anatomy; base; cardiac infarct; coronary attack; coronary infarct; coronary infarction; experience; failure; heart attack; heart infarct; heart infarction; heart revascularization; heavy metal Pb; heavy metal lead; imaging; improved; life span; lifespan; mitral valve replacement; pathophysiology; real time model; repair; repaired; surgery",The Effects of IMR and Mitral Valve Repair in Leaflet Stress Distribution,,99172,ZRG1,Special Emphasis Panel,,1,54854,
7806795,F32,HL,1,,02/01/2010,01/31/2011,PA-07-107,1F32HL099177-01,,NHLBI:47606;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"POPOVIC, RELJA ;",9819357;,1F32HL099177,02/01/2010,06/30/2011,"Alleles; Allelomorphs; Assay; B blood cells; B-Cells; B-Lymphocytes; Back; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CEK2; Cancers; Cell Line; Cell Lines, Strains; CellLine; Chromatin; DNA; DNA Sequence Rearrangement; Data; Deoxyribonucleic Acid; Development; Disease; Disorder; Dorsum; Engineering; Engineerings; FGFR3; FGFR3 gene; Gene Expression; Gene Targeting; Genes; Global Change; Goals; HSFGFR3EX; Histone H3; JTK4; Lead; Malignant Neoplasms; Malignant Tumor; Molecular; Molecular Interaction; Multiple Myeloma; Myeloma, Plasma-Cell; Nuclear; Pathogenesis; Patients; Pb element; Peptide Domain; Play; Program Development; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Domains; Rearrangement; Role; Structure; System; System, LOINC Axis 4; Targetings, Gene; Tertiary Protein Structure; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; cultured cell line; disease/disorder; gain of function; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; histone modification; malignancy; myeloma; myelomatosis; neoplasm/cancer; new therapeutics; next generation therapeutics; novel therapeutics; overexpression; programs; social role; transcription factor; treatment strategy",Importance of MMSET Protein in t(4;14) Multiple Myeloma,,99177,ZRG1,Special Emphasis Panel,,1,47606,
7809972,F32,HL,1,,01/22/2010,01/21/2011,,1F32HL099282-01,,NHLBI:50474;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"CRAIGE, SIOBHAN E;",6953256;,1F32HL099282,01/22/2010,01/21/2013,"AMP Kinase; ATP-AMP Phosphotransferase; ATP-AMP Transphosphorylase; Active Oxygen; Address; Adenylokinase; Apoplexy; Arginine; Arginine, L-Isomer; Autoregulation; Bioavailability; Biologic Availability; Biological Availability; Bizzozero's corpuscle/cell; Blood Platelets; Blood Vessels; Blood capillaries; CNOS; Capillaries; Capillary; Capillary, Unspecified; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Citrulline; Clinical; Constitutive NOS; Cyclic GMP; Data; Deetjeen's body; Dysfunction; EC 1.14.13.39; EC 2.7; ECNOS; EDRF Synthase; ENOS; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium, Vascular; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Event; Extremities; Family; Functional disorder; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanylyl Cyclase-Activating Factor Synthase; HSP-90; HSP90; Hayem's elementary corpuscle; Heat-Shock Proteins 90; Hindlimb; Homeostasis; Human; Human, General; INFLM; Impairment; Inflammation; Ischemia; Isoforms; Kinases; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Ornithine, N5-(aminocarbonyl)-; Limb structure; Limbs; Man (Taxonomy); Man, Modern; Marrow platelet; Mediating; Messenger RNA; Modeling; Molecular; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial Infarct; Myocardial Infarction; Myokinase; NADPH Oxidase; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-Trunk; Organ System, Cardiovascular; Oxygen Radicals; PTP-1B protein; PTP1B enzyme; Pathologic; Patients; Phenotype; Phosphorylation; Phosphotransferases; Physiologic; Physiologic Availability; Physiological; Physiological Homeostasis; Physiopathology; Platelets; Pro-Oxidants; Production; Protein Isoforms; Protein Phosphorylation; Proteins; RNA, Messenger; Reactive Oxygen Species; Recovery; Regulation; Relaxation; Reticuloendothelial System, Platelets; Role; Secondary to; Source; Stroke; Thrombocytes; Transphosphorylases; Vascular Accident, Brain; Vascular Diseases; Vascular Disorder; Vascular Endothelium; Vascular, Heart; Work; adenylate kinase; angiogenesis; bioavailability of drug; blood vessel disorder; brain attack; cGMP; capillary; cardiac infarct; cardiovascular disorder; cerebral vascular accident; circulatory system; coronary attack; coronary infarct; coronary infarction; design; designing; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; gene product; guanosine 3'5' monophosphate; heart attack; heart infarct; heart infarction; hsp90 Family; human NOS3 protein; improved; in vivo; indexing; insight; mRNA; migration; mouse model; novel; overexpression; pathophysiology; protein tyrosine phosphatase 1B; response; social role; stroke; thrombocyte/platelet; vascular",Nox 4 modulation of NO bioavailability and vascular function,,99282,ZRG1,Special Emphasis Panel,,1,50474,
7805233,F32,NS,1,,02/01/2010,01/31/2011,PA-07-107,1F32NS067761-01,,NINDS:47606;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,ANESTHESIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"KOLBER, BENEDICT J;",8198101;,1F32NS067761,02/01/2010,01/31/2013,"Acute Pain; Affect; Allergy; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anxiety; Area; Arthritis; Behavior; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chronic; Complex; Control Locus; EC 2.7.2-; ERK MAP Kinases; Emotional; Encephalon; Encephalons; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Fear; Formalin; Fright; Future; Human; Human, General; Hypersensitivity; INFLM; Inflammation; Intracellular Communication and Signaling; Knowledge; Lead; Learning; MAP kinase; MAPK; Mammals, Mice; Man (Taxonomy); Man, Modern; Mechanics; Mediating; Medulla Spinalis; Metabotropic Glutamate Receptors; Methods and Techniques; Methods, Other; Mice; Mitogen-Activated Protein Kinases; Modeling; Molecular; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nociception; Nucleus; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pathway interactions; Patients; Pb element; Peripheral; Phorbol; Phorbols; Population; Process; Receptors, Metabotropic Glutamate; Research; Role; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spinal Cord; Stimulus; Techniques; Threonine/Tyrosine Protein Kinase; Training; Treatment Efficacy; amygdaloid nuclear complex; arthritic; base; behavioral sensitization; biological signal transduction; chronic pain; chronic painful condition; design; designing; experience; experiment; experimental research; experimental study; extracellular signal related kinase; heavy metal Pb; heavy metal lead; inflammatory pain; inhibitor; inhibitor/antagonist; interdisciplinary approach; interest; intervention development; neuronal; neuronal excitability; new therapeutic target; nociceptive; novel; patch clamp; pathway; public health relevance; receptor coupling; research study; response; social role; therapeutic efficacy; therapeutically effective; therapy development; tool; treatment development",Cellular and molecular mechanisms undelying amygdala-dependent pain modulation,,67761,ZRG1,Special Emphasis Panel,,1,47606,
7805063,F32,NS,1,,02/01/2010,01/31/2011,PA-07-107,1F32NS067945-01,,NINDS:47606;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MARKS, DAVID ;",9831301;,1F32NS067945,02/01/2010,01/31/2012,"21+ years old; AIDS Dementia; AIDS Dementia Complex; AIDS with dementia; AIDS-related dementia; Acquired Immune Deficiency Syndrome related dementia; Address; Administration, Intranasal; Adult; Affect; Age Group Unspecified; Aged 65 and Over; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Anxiety; Behavior; Behavioral; Biochemical; Biochemistry; Brain; Causality; Cell Cycle Proteins; Cell Division Cycle Proteins; Cell-Cycle Regulatory Proteins; Chemistry, Biological; Chronic; Cognitive Discrimination; Cornu Ammonis; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dentate Fascia; Dentate Gyrus; Discrimination; Discrimination (Psychology); Disease; Disease Progression; Disease model; Disorder; Drug Administration, Intranasal; E2F-1; E2F1; E2F1 gene; Elderly; Elderly, over 65; Encephalon; Encephalons; Etiology; Exhibits; Fascia Dentata; GFAC; Gene Targeting; Generations; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Gyrus Dentatus; HIV Dementia; HIV associated dementia; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-related dementia; Hippocampus; Hippocampus (Brain); Human, Adult; Humulin R; IGF; IGF-1; IGF-I; IGF-I-SmC; IGF1; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Growth Factors; Insulin-Like Somatomedin Peptide I; Intervention; Intervention Strategies; Intranasal Administration; Knockout Mice; Life; Maintenance; Maintenances; Mammals, Mice; Memory; Memory Deficit; Memory impairment; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neuron Degeneration; Neurons; Novolin R; Null Mouse; Olfaction; Olfactions; Olfactory Bulb; Pathology; Pathway interactions; Patients; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Play; Prevalence; Primary Senile Degenerative Dementia; Proteins; RBBP3; RBP3; Regimen; Research; Role; Smell; Smell Perception; Solutions; Somatomedin C; Somatomedins; Structure of dentate gyrus; Structure of olfactory bulb; Sulfation Factor; Symptoms; Synapses; Synaptic; Targetings, Gene; Techniques; Testing; Transgenic Organisms; Treatment Cost; United States; Work; adult human (21+); adult neurogenesis; advanced age; age dependent; age group; age related; behavior test; behavioral test; cdc Proteins; clinical efficacy; cost; dementia of the Alzheimer type; density; dentate gyrus; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; disorder model; effective therapy; elders; gene product; geriatric; hippocampal; improved; insulinlike growth factor; interventional strategy; late life; later life; meetings; mouse model; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; neurotoxic; older adult; older person; olfactory bulb; pathway; prevent; preventing; primary degenerative dementia; protein protein interaction; scaffold; scaffolding; senile dementia of the Alzheimer type; senior citizen; social role; success; transgenic",Analysis and Intranasal Treatment of the E2F1 Neurodegenerative Paradigm,,67945,ZRG1,Special Emphasis Panel,,1,47606,
7805939,F32,NS,1,,02/01/2010,01/31/2011,,1F32NS068161-01,,NINDS:49046;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"LIPPMAN BELL, JOCELYN J;",9846429;,1F32NS068161,02/01/2010,01/31/2012,"21+ years old; AMPA Receptors; Acute; Adult; Affect; Age; Ammon Horn; Animals; Blood Coagulation Factor IV; Brain; CNS plasticity; Ca++ element; Calcium; Calcium Ion Signaling; Calcium Signaling; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Signaling; Cells; Childhood; Coagulation Factor IV; Cognition; Cognition Disorders; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Common Rat Strains; Comorbidity; Cornu Ammonis; Data; Defect; Development; Disturbance in cognition; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; EC 2.7; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Epileptogenesis; Factor IV; Figs; Figs - dietary; Forecast of outcome; Functional disorder; Future; Goals; Hippocampus; Hippocampus (Brain); Hour; Human; Human, Adult; Human, General; Hypoxia; Hypoxic; Image; Impaired cognition; Intracellular Communication and Signaling; Kinases; Kinetic; Kinetics; Learning; Life; Link; Long-Term Potentiation; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Memory; Molecular; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuronal Plasticity; Neurons; Oxygen Deficiency; Pathology; Pathway interactions; Patients; Perinatal; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Phosphotransferases; Physiopathology; Plastics; Prognosis; Propionic Acids; Protein Phosphorylation; Protocol; Protocols documentation; Pyramidal neuron; Rat; Rattus; Receptor Protein; Receptors, AMPA; Relative; Relative (related person); Research; Seizure Disorder; Seizures; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Slice; Source; Synaptic plasticity; Testing; Therapeutic; Time; Transphosphorylases; Whole-Cell Recordings; Work; adult human (21+); autism spectrum disorder; base; biological signal transduction; calcineurin phosphatase; cognitive disease; cognitive disorder; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; epilepsia; epileptiform; epileptogenic; experience; hippocampal; hippocampal pyramidal neuron; imaging; in vivo; nervous system disorder; neural plasticity; neurological disease; neuronal; neuroplasticity; outcome forecast; paired stimuli; pathophysiology; pathway; pediatric; prevent; preventing; ratiometric; receptor; response; synapse formation; synaptogenesis; therapeutic target",Calcium signaling as a convergence point of epilepsy and cognitive dysfunction,,68161,ZRG1,Special Emphasis Panel,,1,49046,
7771993,K01,DA,1,,01/15/2010,12/31/2010,PA-09-040,1K01DA027752-01,,NIDA:69088;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BELMONT,UNITED STATES,,07,046514535,US,MA,02478,"MC LEAN HOSPITAL (BELMONT, MA)","MYERS, KARYN M;",3128547;,1K01DA027752,01/15/2010,12/31/2012,"2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol; Abstinence; Acute; Addiction, Drug; Address; Affect; Agonist; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Basal Ganglia; Basal Nuclei; Biological Models; Blotting, Western; Body Tissues; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Cerebellum; Chemical Dependence; Clinical; Common Rat Strains; Complex; Conditioned Stimulus; Contin, MS; Cues; Cycloserine; Data; Dependence; Dependence, Drug; Drug Addiction; Drug Dependency; Drug usage; Drug user; Drugs; Endo Brand of Naloxone Hydrochloride; Environment; Event; Exposure to; Extinction; Extinction (Psychology); Fear; Fright; Fugu Toxin; Glutamate Receptor; HSV vector; Herpes Simplex Virus Vector; Infumorph; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigation; Kadian; Lamepro Brand of Naloxone Hydrochloride; Lateral; Learning; MSir; Mammals, Rats; Mediating; Medication; Memory; Methods; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; NR1; NR1 gene; Naloxone; Narcan; Narcanti; Neurobiology; Neuronal Plasticity; Opiates; Oramorph; Oramorph SR; Outcome; Pharmaceutic Preparations; Pharmaceutical Preparations; Prefrontal Cortex; Proteins; R-4-Amino-3-isoxazolidinone; Rat; Rattus; Receptor Protein; Receptors, N-Methylaspartate; Relapse; Role; Roxanol; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sodium Channel Blockers; Statex SR; Stimulus; Structure; Synaptic plasticity; TTX; Tarichatoxin; Techniques; Testing; Tetradotoxin; Tetrodotoxin; Tissues; Training; United Drug Brand of Naloxone Hydrochloride; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); Viral Vector; Western Blotting; Western Blottings; Western Immunoblotting; Withdrawal; Withdrawal Symptom; Work; alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol; amygdaloid nuclear complex; base; behavioral extinction; biological signal transduction; conditioned fear; drug seeking behavior; drug use; drug withdrawal; drug/agent; experiment; experimental research; experimental study; fear conditioning; gene product; ifenprodil; improved; interest; neural mechanism; neural plasticity; neurobiological; neuromechanism; neuroplasticity; protein blotting; public health relevance; puffer fish toxin; receptor; receptor expression; research study; response; social role; voltage",NMDA Receptor-Mediated Plasticity in Extinction of Conditioned Opiate Withdrawal," PROJECT NARRATIVE Drug withdrawal can be elicited as a conditioned response to cues paired with drug use or withdrawal itself, contributing to relapse even after periods of abstinence. For this reason it is of clinical interest to reduce or eliminate conditioned withdrawal states in recovering addicts. The experiments described in this application will begin a systematic investigation of the neural mechanisms underlying one method of reducing conditioned withdrawal, called extinction, in which withdrawal-eliciting cues are presented repeatedly until the conditioned withdrawal response disappears.",27752,NIDA,Neuropharmacology Research Subcommittee,,1,69088,
7773086,K01,DA,1,,01/15/2010,12/31/2010,PA-09-040,1K01DA027756-01,,NIDA:128604;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"HANLON, COLLEEN A;",7339834;,1K01DA027756,01/15/2010,12/31/2014,"Address; Affect; Aging; Apoplexy; Area; Award; Behavior; Behavioral; Bilateral; Biological Neural Networks; Body of uterus; Brain region; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Cocaine Users; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Corpus; Corpus Callosum; Corpus Callosums; Corpus Uteri; Data; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Disturbance in cognition; Drug usage; Drugs; Ethics Committees, Research; Fiber; Fingers; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Hand; Handedness; IRBs; Image Analyses; Image Analysis; Impaired cognition; Impairment; Individual; Institutional Review Boards; Intracellular Communication and Signaling; Investigation; Investigators; Ipsilateral; K01 Award; K01 Mechanism; K01 Program; Knowledge; Laterality; Left; Link; MRI, Functional; MS (Multiple Sclerosis); Magnetic Resonance Imaging, Functional; Manuscripts; Measures; Medication; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Motor Cortex; Movement; Multiple Sclerosis; Nerve Transmitter Substances; Neurotransmitters; Participant; Pathway interactions; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic pulse; Population; Prefrontal Cortex; Process; Public Health; Pulse; ROC Analysis; Research; Research Ethics Committees; Research Personnel; Research Scientist Development Award; Researchers; Risk Behaviors; Risky Behavior; Science of Statistics; Sclerosis, Disseminated; Senescence; Sensorimotor functions; Signal Transduction; Signal Transduction Systems; Signaling; Statistics; Stealing; Stealings; Stroke; Structure; Students; Task Performances; Testing; Theft; Time; Training; Training Programs; Transcranial magnetic stimulation; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Users, Cocaine; Uterine Body; Vascular Accident, Brain; Writing; at risk behavior; behavioral deficiency; biological signal transduction; body movement; brain attack; career development; cerebral vascular accident; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; design; designing; diffusion tensor imaging; disease/disorder; drug use; drug/agent; experience; experiment; experimental research; experimental study; fMRI; image evaluation; imaging modality; indexing; insular sclerosis; interest; meetings; neural mechanism; neural network; neuromechanism; pathway; public health medicine (field); public health relevance; research study; response; responsible research conduct; senescent; statistics; stroke; therapeutic development; traumatic brain damage; treatment strategy",Cortical Inhibition and Corpus Callosum Integrity in Cocaine Users," Project Narrative: This is a request for 5 years of funding through the ""Mentored Research Scientist Development Award"" (K01) mechanism. The applicant, Dr. Colleen Hanlon, is a neurobiologist with experience using functional magnetic resonance imaging to examine neural networks affected in chronic cocaine users. To further characterize changes in cortical activity in cocaine users, this application proposes a program of training in diffusion tensor imaging (DTI) and transcranial magnetic stimulation (TMS). The long- term goal of the applicant is to become an independent investigator, skilled in the application of multiple imaging modalities that may be used to guide treatment strategies in substance abusing populations. The training plan includes structured training courses in TMS acquisition and analysis, DTI image analysis, and multivariate statistics, as well as ongoing training by a team of mentors. Career development is also a strong component of this application with time devoted to training in the responsible conduct of research, manuscript and grant writing, mentoring students, attendance at scientific meetings, and interactions with the institutional review board. The research component of this award extends prior NIH-funded research complete by Dr. Hanlon, and has been carefully designed to parallel the training plan. The overarching goal of this proposal is to determine the extent to which changes in corpus callosum integrity (Specific Aim #1) and cortical inhibitory tone (Specific Aim #2) are related to atypical BOLD signal changes in the cortex of chronic cocaine users. In addition to extending investigations on sensorimotor laterality, the impact of loss of cortical laterality on cognitive function in cocaine users will also be addressed (Specific Aim #3). These experiments will reveal the extent to which changes in cortical inhibitory tone and corpus callosal integrity may contribute to neurofunctional and behavioral deficiencies in chronic cocaine users. The results of these experiments will be used to further the investigation and development of therapeutic treatment strategies in stimulant dependent individuals.",27756,NIDA,Neuropharmacology Research Subcommittee,,1,128604,
7771313,K01,ES,1,,02/01/2010,01/31/2011,PA-09-040,1K01ES017800-01,,NIEHS:102029;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BOSTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,08,149617367,US,MA,02115,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),"KILE, MOLLY L;",8681881;,1K01ES017800,02/01/2010,01/31/2015,"0-6 weeks old; 21+ years old; Address; Adrenal Gland Neoplasms; Adrenal Tumor; Adult; Animals; Area; Arsenic; Arts; Award; Bangladesh; Biological; Birth; Blood Vessels; Blood flow; Blood leukocyte; Blood, Cord; Body Tissues; Cancer Causing Agents; Carcinogens; Cardiovascular Diseases; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cells; Characteristics; Chemical Exposure; Chemicals; Childhood; Clinical; DNA; DNA Methylation; Data; Deoxyribonucleic Acid; Developed Countries; Developed Nations; Development; Dose; Economics; Education; Educational aspects; Embryonic Tissue, Placenta; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium-Derived Relaxing Factor; Environment; Environmental Epidemiology; Environmental Factor; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiologist; Epidemiology; Epidemiology Research; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Exposure to; Fetal Age; Fetal Growth; Fetal Maturity, Chronologic; Fetus; Generalized Growth; Genes; Genetic; Genetic Materials; Genital System, Female, Ovary; Gestational Age; Growth; Growth Factor Gene; Growth and Development; Growth and Development function; Growth, Fetal; Health; Hepatocyte Nitric Oxide Synthase; Human; Human Development; Human, Adult; Human, General; IGF; IGF-2; IGF-II; IGF2; IGF2 gene; INOS; Inducible Nitric Oxide Synthase; Industrialized Countries; Industrialized Nations; Infant, Newborn; Infant, Small for Gestational Age; Insulin-Like Growth Factor 2; Insulin-Like Growth Factor II; Insulin-Like Growth Factors; Insulin-Like Somatomedin Peptide II; Intervention; Intervention Strategies; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Leukocytes; Life; Liver; Low Birth Weight Infant; Lung; Macrophage Nitric Oxide Synthase; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Materials, Genetic; Measurement; Mentors; Mentorship; Metabolic; Metal exposure; Methylation; Mexico; Mice; Molecular; Mollies; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiplication-Stimulating Activity; Multiplication-Stimulating Factor; Murine; Mus; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Neural Development; Newborn Infant; Newborns; Nitric Oxide; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nutrition; Nutritional; Nutritional Science; O element; O2 element; Oklahoma; Oncogens; Organ; Outcome; Ovary; Oxygen; Parents; Parturition; Pb element; Perinatal; Perinatal Epidemiology; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Population; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Protein Methylation; Proto-Oncogene, Growth Factor; Public Health; Public Health Schools; Recruitment Activity; Research; Research Associate; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Risk; Schools, Public Health; Science of nutrition; Small for Gestational Age Infant; Somatomedin A; Somatomedin MSA; Somatomedins; Structure; Sulfation Factor; Tars; Tissue Growth; Tissues; Toxic effect; Toxicities; Training; Tumor of the Adrenal Gland; Umbilical Cord; Umbilical Cord Blood; Umbilical cord structure; Umbilical vein; VLBW (human); White Blood Cells; White Cell; adrenal neoplasm; adult human (21+); body system, hepatic; cardiovascular disorder; career development; cohort; cost effective; design; designing; drinking water; endothelial cell derived relaxing factor; environmental chemical; environmental risk; experience; experiment; experimental research; experimental study; exposure to metal; fetal cord blood; heavy metal Pb; heavy metal lead; human NOS2A protein; iNOS enzyme; imprint; in utero; indexing; insulinlike growth factor; interventional strategy; intrauterine growth; low birth weight infant human; low birthweight; neurodevelopment; newborn human (0-6 weeks); nitric oxide synthase, Type II; nutrition; ontogeny; organ system, hepatic; pediatric; post-doc; post-doctoral; prenatal; prenatal exposure; prenatally exposed; programs; prospective; public health medicine (field); public health priorities; public health relevance; pulmonary; recruit; research study; skills; small for gestational age; toxicant; unborn; vascular; white blood cell; white blood corpuscle",Epigenetic Effects of Prenatal Arsenic Exposure and Fetal Growth," NARRATIVE Adverse fetal growth can lead to low birthweight which is associated with increased morbidity and mortality. As such, understanding the factors that contribute to adverse fetal growth is a public health priority. The proposed studies will fill important research gaps in our knowledge of arsenic toxicity and its impact on fetal growth that could inform both clinical and public health interventions in developing and developed countries.",17800,ZES1,Special Emphasis Panel,,1,102029,
7788641,K01,HD,1,,02/01/2010,01/31/2011,PA-09-040,1K01HD060693-01A1,,NICHD:114558;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,MILWAUKEE,UNITED STATES,OTHER HEALTH PROFESSIONS,04,046929621,US,WI,532011881,MARQUETTE UNIVERSITY,"SCHINDLER-IVENS, SHEILA M;",7095598;,1K01HD060693,02/01/2010,01/31/2015,"Accounting; Acute; Age; Apoplexy; Area; Artifacts; BOLD response; Beds; Bilateral; Brain; Brain Hemisphere; Brain imaging; Brain region; Cell Communication and Signaling; Cell Signaling; Cerebellum; Cerebral Hemisphere; Cerebral Stroke; Cerebral cortex; Cerebral hemisphere structure (body structure); Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Chronic Phase; Clinical; Clinical Trials; Clinical Trials, Unspecified; Detection; Development Plans; Encephalon; Encephalons; Event; Functional Magnetic Resonance Imaging; Funding; Goals; Hand; Hemipareses; Human; Human, General; Imaging technology; Impairment; Intracellular Communication and Signaling; K01 Award; K01 Mechanism; K01 Program; Laboratories; Lead; Leg; Locomotion; Locomotor Recovery; Lower Extremity; Lower Limb; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measures; Membrum inferius; Membrum superius; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Methods; Methods and Techniques; Methods, Other; Modeling; Morphologic artifacts; Motion; Motor; Movement; Nervous; Nervous System, Brain; Participant; Pb element; Phase; Physical Health Services / Rehabilitation; Physiologic; Physiological; Plans, Development; Procedures; Process; Programs (PT); Programs [Publication Type]; QOL; Quality of life; R01 Mechanism; R01 Program; RPG; Recovery; Rehabilitation; Rehabilitation Research; Rehabilitation therapy; Rehabilitation, Medical; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Scientist Development Award; Scientist; Side; Signal Transduction; Signal Transduction Systems; Signaling; Stroke; Survivors; Techniques; Technology; Testing; Time; Training; Treatment Effectiveness; Upper Extremity; Upper Limb; Vascular Accident, Brain; Walking; Work; base; biological signal transduction; blood oxygenation level dependent response; body movement; brain attack; brain control; brain visualization; career; career development; cerebral vascular accident; chronic stroke; clinical investigation; computerized data processing; data processing; design; designing; effective therapy; fMRI; heavy metal Pb; heavy metal lead; hemiparetic; hemisphere damage; improved; insight; mind control; motor control; nerve injury; neural; neural control; neural injury; neural regulation; neuroadaptation; neuroregulation; novel; post stroke; post-doctoral training; postdoctoral training; poststroke; programs; public health relevance; rehabilitative; relating to nervous system; response; responsible research conduct; signal processing; skills; somatosensory; stroke; success; tool",Supraspinal Contributions to Locomotor Control and Recovery after Stroke, Project Narrative Many stroke survivors fail to regain walking ability which leads to poor quality of life. A better understanding of how the brain controls locomotion many lead to more effective treatments. The results of this study will provide insight into how the post-stroke brain controls locomotion and may lead to novel treatments for improving locomotion after stroke.,60693,CHHD,National Institute of Child Health and Human Development Initial Review Group,A1,1,114558,
7790109,K01,HD,1,,01/20/2010,12/30/2010,PA-09-040,1K01HD060886-01A1,,NICHD:122427;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,WASHINGTON,UNITED STATES,,00,077366664,US,DC,20010,NATIONAL REHABILITATION HOSPITAL,"HARRIS-LOVE, MICHELLE LYNN;",9464491;,1K01HD060886,01/20/2010,12/30/2014,"Address; Affect; Apoplexy; Area; Arm; Brain; Brain imaging; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Data; Development; Dorsal; Encephalon; Encephalons; Equipment; Fellowship; Fingers; Functional Magnetic Resonance Imaging; Goals; Hand; Impairment; Individual; Institution; Intervention; Intervention Strategies; Intervention Trial; Investigators; K-Awards; K-Series Research Career Programs; Learning; Lesion; Life; Love; MRI, Functional; Magnetic Resonance Imaging, Functional; Measures; Membrum superius; Mentors; Methods and Techniques; Methods, Other; Mission; Motor; Motor Cortex; Movement; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous; Nervous System, Brain; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Patients; Performance; Physical Health Services / Rehabilitation; Population; Postdoc; Postdoctoral Fellow; Principal Investigator; Programs (PT); Programs [Publication Type]; Recovery; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Research; Research Associate; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Training; Researchers; Role; Severities; Step retraining; Step training; Stroke; Techniques; Transcranial magnetic stimulation; United States; United States National Institutes of Health; Upper Extremity; Upper Limb; Upper arm; Vascular Accident, Brain; Work; base; blood oxygen level dependent; body movement; brain attack; brain visualization; burden of disease; burden of illness; cerebral vascular accident; chronic stroke; design; designing; disability; disease burden; effective intervention; experience; fMRI; improved; intervention development; interventional strategy; motor impairment; neural; neural mechanism; neuromechanism; novel; post stroke; post-doc; post-doctoral; poststroke; programs; rehabilitative; relating to nervous system; social role; stroke; stroke rehab; stroke rehabilitation; therapy development; treatment development; years of life lost to disability; years of life lost to disease",Reach Forward: Mechanisms of Practice-Induced Reaching Improvement After Stroke," Relevance: The development of interventions to improve motor abilities of the affected arm after stroke is a vital part of alleviating the disability that results from this prevalent condition. In order to develop effective rehabiliation interventions, the mechanisms of motor recovery in people with substantial stroke-induced arm impairment must be understood.",60886,ZHD1,Special Emphasis Panel,A1,1,122427,
7787252,K01,MH,1,,01/15/2010,12/31/2010,PA-09-040,1K01MH085710-01A1,,NIMH:138723;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,ADMINISTRATION,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"GREEN, JENNIFER GREIF;",7892822;,1K01MH085710,01/15/2010,12/31/2014,"0-11 years old; Address; Adolescent; Adolescent Youth; Analysis, Data; Area; Behavior Disorders; Care, Health; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Characteristics; Child; Child Youth; Children (0-21); Climate; Communities; Comorbidity; Competence; Consultations; Continuity of Care; Continuity of Patient Care; Continuum of Care; Counselor; DSM; Data; Data Analyses; Data Set; Dataset; Delivery of Health Care; Detection; Diagnosis; Diagnostic and Statistical Manual; Disease; Disorder; Early identification; Early treatment; Economics; Educational Mainstreaming; Effectiveness; Emotional; Enabling Factors; Epidemiology; Evaluation; Evaluation Research; Factors, Enabling; Family; Feedback; Foundations; Funding; Goals; Health Care Research; Health Sciences, Allied and Health Services Delivery; Health Services Evaluation; Health Services Research; Health system; Healthcare; Healthcare Delivery; Healthcare Research; Human, Child; Impairment; Improve Access; Individual; Intervention; Intervention Strategies; Interview; K-Awards; K-Series Research Career Programs; Knowledge; Link; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Measures; Medical Care Research; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Mentors; Meteorological Climate; Methods and Techniques; Methods, Other; Morbidity; Morbidity - disease rate; Neighborhoods; Outcome; PROV; Pattern; Phase; Play; Policies; Predisposing Factor; Preparation; Preventive Intervention; Process; Professional counselor; Program Evaluation; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Provider; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychologist; Psychometric; Psychometrics; Public Health; Public Policy; R01 Mechanism; R01 Program; RPG; Reading; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research, Evaluation; Resource Allocation; Resources; Role; Sampling; School Health Nursing; School Health Services; School Nursing; School-Based Services; Schools; Services; Social Workers; Source; Students; Survey Instrument; Surveys; System; System, LOINC Axis 4; Techniques; Testing; Time; Training; Training Activity; Unspecified Mental Disorder; Variant; Variation; Workers, Social; Youth; Youth 10-21; base; behavioral disorder; care systems; career; child mental health service; children; climatic; community based service; design; designing; disease/disorder; experience; health care delivery; high school; improved; intervention design; intervention development; interventional strategy; juvenile; juvenile human; mental illness; preventional intervention strategy; programs; psychological disorder; public health medicine (field); public health relevance; services research; skills; social role; systems of care; therapy design; therapy development; treatment design; treatment development; youngster",Evaluating the Role of School in Adolescent Mental Health Service Provision," This study aims to clarify the role of schools in identifying psychiatric disorders and providing referrals for mental health services. Delineating these roles is critical to informing the development of interventions that can increase access to mental health services. A substantial proportion of adolescent mental health services are provided by schools or at their behest, interventions to improve effective service provision have important public health implications.",85710,SRNS,Mental Health Services in Non-Specialty Settings,A1,1,138723,
7785629,K01,MH,1,,01/11/2010,12/31/2010,PA-09-040,1K01MH085812-01A1,,NIMH:155595;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOULDER,UNITED STATES,PSYCHOLOGY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"KELLER, MATTHEW CHARLES;",9432662;,1K01MH085812,01/11/2010,12/31/2014,"Accounting; Active Follow-up; Affect; Area; Award; Behavioral Genetics; Bio-Informatics; Bioinformatics; CNP; Collaborations; Copy Number Polymorphism; DNA Resequencing; Data; Diagnostic tests; Disease; Disorder; Educational process of instructing; Educational workshop; Environment; Equilibrium; Framingham Heart Study; Funding; Future; Gene Copy Number; Gene Dosage; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinants of Behavior; Genetic Diversity; Genetic Risk; Genetic Variation; Genetic defect; Genetics, Behavioral; Genetics, Human; Genome; Genomics; Goals; History; Human Genetics; Individual; Institutes; Interdisciplinary Research; Interdisciplinary Study; Investigation; Investigators; K01 Award; K01 Mechanism; K01 Program; Knowledge; Lead; Link; Literature; Major Depressive Disorder; Mental Retardation; Mental disorders; Mental health disorders; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Molecular; Molecular Genetic; Molecular Genetics; Multidisciplinary Collaboration; Multidisciplinary Research; Mutation; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Pb element; Pilot Projects; Play; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychiatry; R01 Mechanism; R01 Program; RPG; Recording of previous events; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Scientist Development Award; Research Training; Researchers; Resequencing; Risk; Role; Running; Sampling; Schizophrenia; Schizophrenic Disorders; Source; Study, Interdisciplinary; Teaching; Training; Translational Research; Translational Research Enterprise; Translational Science; United States National Institute of Mental Health; Unspecified Mental Disorder; Variant; Variation; Variation (Genetics); Workshop; Writing; X Chromosome; allelic variant; balance; balance function; behavior genetics; career; career development; conference; copy number variation; dementia praecox; disease risk; disease/disorder; disorder risk; follow-up; genetic variant; genome mutation; genome sequencing; graduate student; heavy metal Pb; heavy metal lead; major depression; mental illness; pilot study; programs; psychiatric genetics; psychogenetics; psychological disorder; public health relevance; schizophrenic; skills; social role; symposium; translation research enterprise",Evolutionary Roles of Homozygosity & Copy Number Variation in Mental Disorders," Project Narrative The proposed project should increase the molecular genetic and evolutionary understanding of schizophrenia and major depression, clarifying the degree to which rare versus common variants account for their risk, leading to follow-up (e.g., resequencing) investigations of important genomic regions, and potentially informing translational research aimed at developing diagnostic tests and treatments related to gene dosage.",85812,BGES,Behavioral Genetics and Epidemiology Study Section,A1,1,155595,
7770425,K01,MH,1,,01/06/2010,12/31/2010,PA-09-040,1K01MH087845-01,,NIMH:161011;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SMITH, KAREN MULLER;",8632123;,1K01MH087845,01/06/2010,12/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 0-11 years old; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; AD/HD; ADHD; Address; Affinity Chromatography; Analysis, Data; Area; Astrocytes; Astrocytus; Astroglia; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Behavioral inhibition; Binding; Binding (Molecular Function); Bipolar Depression; Blotting, Western; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Maturation; Cell Signaling; Cell Transplantation; Cells; Cerebral cortex; Child; Child Youth; Childhood; Children (0-21); Chromatography, Affinity; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cognition; Connector Neuron; Control Animal; Core Facility; Cultured Cells; Cyclic Somatostatin; DNA Synthesis Factor; Data Analyses; Depression; Development; Development Plans; Developmental Biology; Disease; Disorder; Doctor of Philosophy; Dorsal; Dysfunction; ECGF; Educational workshop; Electroporation; Embryo; Embryonic; Encephalon; Encephalons; Endothelial Cell Growth Factor; Environment; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Event; Exhibits; FGF; FGF-1 receptor tyrosine kinase; FGFR-1; FGFR1; FGFR1 protein; FGFR1 tyrosine kinase; Fibroblast Growth Factor; Fibroblast Growth Factor Receptor 1; Fibroblast Growth Regulatory Factor; Fire - disasters; Fires; Functional disorder; Future; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gilles de la Tourette syndrome; Gilles de la Tourette's Disease; Glia; Glial Cells; Goals; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; Guinon's disease; HBGF; Hand; Health; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; In Vitro; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Journals; Kanner's Syndrome; Kolliker's reticulum; Learning; Light; Magazine; Mammals, Mice; Medial; Mediating; Mental Depression; Mental disorders; Mental health disorders; Mentors; Mentorship; Messenger RNA; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Mutation; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurodevelopmental Disorder; Neuroglia; Neuroglial Cells; Neurological Development Disorder; Neurons; Neurosciences; Non-neuronal cell; Output; Parvalbumins; Pathway interactions; Pattern; Performance; Perinatal; Ph.D.; PhD; Phenotype; Photoradiation; Physiopathology; Pilot Projects; Plans, Development; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Property; Property, LOINC Axis 2; Proteins; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; RT-PCR; RTPCR; Research; Research Design; Research Proposals; Research Resources; Research Training; Resources; Reverse Transcriptase Polymerase Chain Reaction; Ribosomes; Role; SRIH; SRIH-14; Schizophrenia; Schizophrenic Disorders; Science of Statistics; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Transduction; Signal Transduction Systems; Signaling; Somatostatin; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; Statistics; Study Type; Synapses; Synaptic; System; System, LOINC Axis 4; TAM; Tamoxifen; Techniques; Telencephalon; Testing; Tic Disorder, Combined Vocal and Multiple Motor; Time; Tourette Syndrome; Tourette's; Tourette's Disease; Tourette's Disorder; Tourette's Syndrome; Training; Training Programs; Transcript; Transgenes; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Transplantation; Unspecified Mental Disorder; Validation; Western Blotting; Western Blottings; Western Immunoblotting; Work; Workshop; affinity purification; attention deficit hyperactive disorder; behavior test; behavioral control; behavioral test; biological signal transduction; brain cell; calbindin 2; calretinin; career; career development; cell cortex; cell type; children; conference; critical period; dementia praecox; developmental neurobiology; disease/disorder; excitatory neuron; experiment; experimental research; experimental study; frontal cortex; frontal lobe; gene product; genome mutation; growth hormone release inhibiting factor; in vivo; inhibitory neuron; innovate; innovation; innovative; insight; knowledge base; language translation; mRNA; maladie des tics; mental illness; microarray technology; mouse model; mouse mutant; mutant; nerve cement; neural; neurobiological; neuronal; neuronal circuitry; neuropsychiatric; neuropsychiatry; neurotrophic factor; neurotrophin; neutrophin; novel; pathophysiology; pathway; pediatric; pilot study; post-doctoral training; postdoctoral training; postnatal; prevent; preventing; progenitor; protein blotting; psychological disorder; public health relevance; relating to nervous system; research study; reverse transcriptase PCR; schizophrenic; social role; statistics; study design; symposium; tic de Guinon; tissue culture; transgenic; transplant; vector; youngster",The Role of Astrocytes in Cortical Interneuron Development,"  This project will address the postnatal development of an important subtype of neurons, cortical inhibitory interneurons, which are diminished in schizophrenia and bipolar depression, and in mice lacking the Fgfr1 gene. The research will focus on the role of glia, supportive cells of the brain that express Fgfr1, in maintaining the health and maturation of inhibitory interneurons at a time when interneurons are integrating into the brain circuitry. The ultimate goal of this research is to identify mechanisms that contribute to interneuron maturation and survival, possibly leading to novel therapies aimed at preventing or reversing interneuron disruption in psychiatric illnesses.",87845,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,1,161011,
7788779,K08,DK,1,,03/01/2010,02/28/2011,PA-09-042,1K08DK083507-01A1,,NIDDK:148500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PORTLAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"NAUGLER, WILLSCOTT E;",8038752;,1K08DK083507,03/01/2010,02/28/2015,"21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-; Abscission; Absorption; Acids, Bile; Acute Liver Failure; Adeno-Associated Viruses; Artificial Liver; Autoregulation; Back; Bile; Bile Acids; Bile Duct Obstruction; Bile Juice; Bile Salt; Bile Tract; Bile fluid; Biliary; Biliary Stasis; Biliary System; Biliary Tract; Biliary Tree; Biliary tract structure; Bilirubin; Bilirubin IX alpha; Bilirubin, total; Bioartificial Liver; Blood; Blood Coagulation Disorders; Blood Serum; Cell Communication and Signaling; Cell Signaling; Cell division; Cells; Cholest-5-en-3-ol (3beta)-; Cholestasis; Cholesterol; Cirrhosis; Clinical; Coagulation Disorder; Coagulopathy; Comprehension; DNA Molecular Biology; Data; Dependovirus; Detergents; Development; Disease; Disorder; Distal part of ileum; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Encephalopathies; Environment; Equipment; Event; Excision; Excretory function; Extirpation; Fats; Fatty acid glycerol esters; Fellowship; Five-Year Plans; Fulminating Hepatic Failure; Fulminating Liver Failure; Funding; Gastroenterology; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genetic; Genetic Algorithm; Genetic Programming; Goals; Health Sciences; Hepatic; Hepatic Cancer; Hepatic Cells; Hepatic Disorder; Hepatic Failure, Acute; Hepatic Failure, Fulminant; Hepatic Mass; Hepatic Parenchymal Cell; Hepatocarcinogenesis; Hepatocyte; Hepatology; Hepatotoxic effect; Hepatotoxicity; Homeostasis; Human Resources; INFLM; In Vitro; Inflammation; Injury; Injury to Liver; Internal Medicine; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Knowledge; Laboratories; Ligands; Lipids; Liver; Liver Carcinogenesis; Liver Cells; Liver Failure, Acute; Liver Failure, Fulminant; Liver Mass; Liver Regeneration; Liver Stem Cell; Liver Toxicity; Liver diseases; Liver, Artificial; Malignant neoplasm of liver; Mammals, Mice; Mammals, Rodents; Manpower; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane Transport Proteins; Membrane Transporters; Mentors; Methods; Mice; Modeling; Molecular Biology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Natural regeneration; Nuclear Receptors; Operation; Operative Procedures; Operative Surgical Procedures; Oregon; Outcome; Outcome Study; Partial Hepatectomy; Pathway interactions; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiological Homeostasis; Physiology; Plans, Five-Year; Portal Vein; Portal vein structure; Postdoc; Postdoctoral Fellow; Prevention; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Receptor Protein; Receptor Signaling; Recovery; Regeneration; Removal; Research; Research Associate; Research Personnel; Researchers; Residencies; Reticuloendothelial System, Blood; Rodent; Rodent Model; Rodentia; Rodentias; Role; Salts, Bile; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Study, Outcome; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Terminal Ileum; Testing; Toxic effect; Toxic effect on liver cells; Toxicities; Translational Research; Translational Research Enterprise; Translational Science; Transplantation; Universities; Work; absorption; adeno associated virus group; base; bile obstruction; bile occlusion; bile salts; biliary tract; biological signal transduction; blood glucose regulation; body system, hepatic; bowel; carcinogenesis in the liver; career; clotting disorder; disease/disorder; drug/agent; excretion; fulminant hepatic failure; glucose control; glucose homeostasis; glucose regulation; hepatic cell proliferation; hepatic cellular proliferation; hepatocellular carcinogenesis; hepatocyte cell proliferation; hepatocyte cellular proliferation; hepatocyte proliferation; hepatopathy; hepatoxicity; in vivo; in vivo Model; innovate; innovation; innovative; liver cancer; liver cancer pathogenesis; liver cell proliferation; liver cellular proliferation; liver disorder; liver function; malignant liver tumor; organ system, hepatic; partial excision of liver; pathway; personnel; post-doc; post-doctoral; prevent; preventing; programs; public health relevance; receptor; regenerate; regenerative; resection; response; shRNA; short hairpin RNA; small hairpin RNA; social role; solute; subtotal hepatectomy; surgery; translation research enterprise; transplant; uptake",Role of Bile Acids in the Initiation of Liver Regeneration, Project Narrative This contribution is significant because it is expected to provide a physiological reason for liver regeneration which can be used to manipulate hepatocyte proliferation for the purposes of preventing and treating the most common liver disease states.,83507,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,A1,1,148500,
7769689,K08,EY,1,,02/01/2010,01/31/2011,PA-09-042,1K08EY019880-01,,NEI:81000;,2010,NATIONAL EYE INSTITUTE,,CLEVELAND,UNITED STATES,PHARMACOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"MAEDA, TADAO ;",9693991;,1K08EY019880,02/01/2010,01/31/2015,"A/J Mouse; Address; Affect; Age; Age-Months; Aging; Biochemical; Brain; C57BL/6 Mouse; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chromosome Substitution Strain; Chromosomes; Clinical; Cone; Cones (Eye); Cones (Retina); Consomic Strain; Consomic Strain/Chromosome Substitution Strain; Cranial Nerve II; DNA Sequence; Dark Adaptation; Deterioration; Disease; Disorder; Drugs; Dysfunction; Electroretinography; Encephalon; Encephalons; Evaluation; Exhibits; Eye; Eyeball; Functional disorder; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Histology; Human; Human, General; Image; Intervention; Intervention Strategies; Intervention, Genetic; Intracellular Communication and Signaling; Investigation; Life; Light; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Modeling; Molecular; Molecular Biology, Gene Therapy; Mouse Strains; Murine; Mus; Mutation; Natural regeneration; Nervous System, Brain; Optic Nerve; Pathology; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Phototransduction; Physiologic; Physiological; Physiopathology; Process; Proteins; QTL; Quantitative Trait Loci; Reaction; Regeneration; Research; Retina; Retinal; Retinal Cone; Retinal Degeneration; Retinal Diseases; Retinal Disorder; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Rhodopsin; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Rods and Cones; Scotopic Adaptation; Second Cranial Nerve; Senescence; Series; Sight; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Subcellular Process; Testing; Therapy, DNA; Vertebrate Photoreceptors; Vision; Vision Disorders; Visual; Visual Disorder; Visual Perception; Visual Purple; Visual Receptor; Visual Transduction; age dependent; age related; base; biological signal transduction; chromophore; cone cell; disease/disorder; drug/agent; early onset; electroretinogram; experiment; experimental research; experimental study; gene product; gene therapy; genetic therapy; genome mutation; imaging; improved; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; pathophysiology; prevent; preventing; public health relevance; regenerate; research study; response; retina degeneration; retina disease; retina disorder; retinal degenerative; retinopathy; rod cell; senescent; visual cycle",Genetics and Therapy of Age-related Retinal Dysfunction in A/J Mice," NARRATIVE  A/J mice exhibit spontaneous early-onset progressive age-related retinal dysfunction similar to aging humans, and are therefore an excellent model to study the underlying mechanisms of ARD. We will use a simplified genetic approach to determine which chromosome(s) in the A/J mouse are likely to contribute to this deficit. We also will test the response of these mice to two artificial retinoids that improve other visual disorders by affecting the retinoid (visual) cycle in photoreceptor cells of the retina. ",19880,ZEY1,Special Emphasis Panel,,1,81000,
7787336,K08,GM,1,,02/01/2010,01/31/2011,PA-09-042,1K08GM086511-01A1,,NIGMS:119610;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"SALL, JEFFREY W.;",9344223;,1K08GM086511,02/01/2010,01/31/2014,"0-11 years old; 1-Phosphatidylinositol 3-Kinase; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; 5-Oxazolecarboxylic acid, 2-(6-(bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Aminalon; Aminalone; Ammon Horn; Anesthesia; Anesthesia procedures; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, General; Animal Neonates; Animals; Animals, Newborn; Architecture; Area; Assay; BUdR; Bicuculline; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blotting, Western; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Butanoic acid, 4-amino-; Ca++ element; Calcium; California; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Death; Cell Division Cycle; Cell Signaling; Cell division; Cell surface; Cell-Death Protease; Cells; Chelating Agents; Chelators; Child; Child Youth; Children (0-21); Coagulation Factor IV; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Common Rat Strains; Communities; Complexons; Cornu Ammonis; Data; Dentate Fascia; Dentate Gyrus; Development; Development Plans; Differentiation and Growth; Disturbance in cognition; EC 2.7.2-; Effects, Longterm; Engineering / Architecture; Enzymes; Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Event; Extracellular Signal-Regulated Kinases; Factor IV; Fascia Dentata; Fluorescence; Funding; Fura-2; Future; GABA; General Anesthesia; General anesthetic drugs; Generalized Growth; Goals; Growth; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Hour; Human, Child; ICE-like protease; Impaired cognition; In Vitro; Instruction; Intracellular Communication and Signaling; Isoflurane; Knowledge; Laboratories; Lead; Learning; Learning Disabilities; Learning disability; Link; Long-Term Effects; MAP kinase; MAPK; Mammals, Rats; Mammals, Rodents; Mediating; Memory; Mentors; Mitogen-Activated Protein Kinases; Modeling; Mother Cells; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NIH; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; National Institutes of Health; National Institutes of Health (U.S.); Neonatal; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Development; Neural Growth; Neural Stem Cell; Neurocyte; Neuronal Growth; Neurons; Newborn Animals; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Pb element; Perioperative Care; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Plans, Development; Play; Principal Investigator; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; PtdIns 3-Kinase; Publications; Qualifying; Rat; Rattus; Receptor Activation; Receptor Protein; Receptors, N-Methylaspartate; Reporting; Research; Retrospective Studies; Rodent; Rodentia; Rodentias; Role; San Francisco; Scientific Publication; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Specificity; Stem cells; Structure; Structure of dentate gyrus; Testing; Tissue Growth; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; United States National Institutes of Health; Universities; Uridine, 5-bromo-2'-deoxy-; Western Blotting; Western Blottings; Western Immunoblotting; base; biological signal transduction; brain cell; brain tissue; career development; caspase; children; clinical practice; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cystein protease; cystein proteinase; cysteine endopeptidase; dentate gyrus; experiment; experimental research; experimental study; fluoromethyl hexafluoroisopropyl ether; fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; gamma-Aminobutyric Acid; genetic manipulation; gliogenesis; heavy metal Pb; heavy metal lead; hippocampal; immunocytochemistry; in vivo; migration; necrocytosis; neonatal animal; nerve stem cell; neural; neural precursor cell; neural progenitor cells; neurodevelopment; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; ontogeny; pathway; premature; progenitor; programs; protein blotting; public health relevance; receptor; relating to nervous system; research study; sevoflurane; skills; social role; stem; stem cell biology; youngster",Volatile anesthetic alteration of neural precursor cell cycle and fate decisions, PROJECT NARRATIVE Recent identification of long-term cognitive deficits following general anesthesia in neonatal animals has caused significant concern for clinical practice. This proposal seeks to understand how anesthetics alter neural development and neural precursors in the hippocampus. ),86511,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1,1,119610,
7771164,K08,HD,1,,02/01/2010,01/31/2011,PA-09-042,1K08HD062638-01,,NICHD:137160;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SALT LAKE CITY,UNITED STATES,PEDIATRICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"ARRINGTON, CAMMON ;",9245058;,1K08HD062638,02/01/2010,01/31/2015,"0-11 years old; Binding; Binding (Molecular Function); Biological Models; Brachydanio rerio; Cardiac; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cells; Child; Child Youth; Children (0-21); Cilia; Complex; Congenital Heart Defects; Danio rerio; Defect; Detection; Development; Extracellular Fluid; Gastrula; Gene Expression; Genes; Genetic; HSPG; Handedness; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; Heparan Sulfate Proteoglycan; Human; Human, Child; Human, General; Lateral; Laterality; Lead; Left; Mammals, Mice; Man (Taxonomy); Man, Modern; Mesoderm; Mice; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Morbidity; Morbidity - disease rate; Morphogenesis; Mortality; Mortality Vital Statistics; Murine; Mus; Nodal; Organ; Organ System, Cardiovascular; Organogenesis; Pathway interactions; Pattern; Pb element; Play; Position; Positioning Attribute; Process; Proteoheparan Sulfate; Role; Side; Structure; System; System, LOINC Axis 4; Testing; Tube; VESCL; Vascular, Heart; Vertebrate Animals; Vertebrates; Vesicle; Zebra Danio; Zebra Fish; Zebrafish; base; children; ciliogenesis; cilium biogenesis; circulatory system; congenital cardiac disorder; congenital heart disease; congenital heart disorder; epithelial to mesenchymal transition; fibroglycan; fluid flow; heart defect; heavy metal Pb; heavy metal lead; improved; malformation; pathway; precursor cell; public health relevance; social role; syndecan-2; vertebrata; youngster",Establishing Left-Right Asymmetry in Vertebrates," PROJECT NARRATIVE/RELEVANCE Abnormalities in left-right development often lead to complex congenital heart defects with significant associated morbidity and mortality but little is known about the molecular anomalies that cause these defects. Understanding the mechanisms that regulate left-right development in model vertebrate systems will advance our ability to understand, detect, and treat human cardiovascular malformations.",62638,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,137160,
7786785,K08,HL,1,,02/01/2010,01/31/2011,PA-09-042,1K08HL092296-01A2,,NHLBI:133110;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"O'REILLY, PHILIP JAMES;",8553145;,1K08HL092296,02/01/2010,01/31/2015,"3-10C; 4q Chemokine; AMCF-I; Acute; Advisory Committees; Alveolar; Animals; Antiproteases; Area; Arts; Biophysics; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bronchoalveolar Lavage Fluid; C-X-C Chemokines; COAD; COPD; CXC Chemokines; CXCL8; Cells; Chemicals; Chronic; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Chronic lung disease; Clinical; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Collagen; Development; Diagnosis; Disease; Disorder; Doctor of Philosophy; Early Diagnosis; Education; Educational aspects; Endopeptidase Inhibitors; Environment; Esteroproteases; Evaluation; Exposure to; GCP-1; GCP1; Generations; Grant; Heterophil Granulocyte; Human; Human, General; Hypertrophy, Right Ventricular; IL-8; IL8; IL8 gene; INFLM; Immunology; Immunology (Including BRMP); Immunology (NCI Program); In Vitro; Inflammation; Inflammatory; Investigators; K60; LECT; LUCT; LYNAP; Lead; Lung; Lung Inflammation; Lung diseases; MDNCF; MONAP; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Master of Science; Medicine; Mentors; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods; Modeling; NAF; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pathogenesis; Patients; Pb element; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Ph.D.; PhD; Physicians; Physiology; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prevention; Pro-Gly-Pro; Pro-Pro-Gly; Process; Production; Programs (PT); Programs [Publication Type]; Protease Antagonists; Protease Inhibitor; Proteases; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; Public Health; Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; R01 Mechanism; R01 Program; RPG; Reaction; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Right Ventricular Hypertrophy; Role; SCYB8; Science of Medicine; Scientist; Signal Pathway; Smoking; Sputum; Staging; Stimulus; TSG-1; Task Forces; Testing; Training; Training Programs; United States; aerosolized; alpha-Chemokines; analog; b-ENAP; base; biomarker; career development; cigarette smoking; clinical test; cofactor; conference; cytokine; disease/disorder; early detection; heavy metal Pb; heavy metal lead; in vivo; lung disorder; metalloproteinase (general); mouse model; neutrophil; novel; post-proline cleaving enzyme; post-proline endopeptidase; pre-clinical; preclinical; programs; prolinal; proline aldehyde; proline endopeptidase; proline specific endopeptidase; prolyl endopeptidase; prolyl endopeptidase (thiol-dependent); prolyl endopeptidase I; prolyl oligopeptidase; prolyl-glycyl-proline; prolyl-prolyl-glycine; public health medicine (field); pulmonary; receptor binding; research clinical testing; research facility; response; smoke cigarette; social role; symposium; therapeutic target","Prolyl endopeptidase, a novel protease important in lung inflammation"," Chronic obstructive pulmonary disease (COPD) is caused by cigarette smoking and is a major public health problem in the United States and worldwide. COPD is frequently misdiagnosed or diagnosed at an advanced stage when options for treatment and prevention are limited. In this grant, we are studying fragments of collagen generated by the action of inflammatory cells in the lung which we believe are important in the development of COPD. Detecting and inhibiting these fragments may produce new methods for the early diagnosis and treatment of this devastating disease.",92296,ZHL1,Special Emphasis Panel,A2,1,133110,
7788013,K08,HL,1,,01/15/2010,11/30/2010,PA-09-042,1K08HL095655-01A1,,NHLBI:138215;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WEST LAFAYETTE,UNITED STATES,OTHER HEALTH PROFESSIONS,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"OVERHOLSER, BRIAN R;",9496772;,1K08HL095655,01/15/2010,11/30/2014,"Acute; Adrenergic Agents; Adrenergic Drugs; Adrenergic Receptor; Adrenergics; Adrenoceptors; Arrhythmia; Atrial; Atrial Fibrillation; Auricle of Heart; Auricular Fibrillation; Behavior; Blood Coagulation Factor IV; Ca++ element; Calcium; Cardiac Arrhythmia; Cardiac Atrium; Cardiac Myocytes; Cardiocyte; Clinical; Clinical Pharmacology; Clinical Research; Clinical Study; Coagulation Factor IV; Coupled; Development; Environment; Experimental Models; Experimental Models, Other; Exposure to; Factor IV; Fibrosis; Foundations; Generations; Goals; Heart Arrhythmias; Heart Atrium; Heart failure; Heart myocyte; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Investigation; Laboratories; Lead; Left Ventricular Dysfunction; Link; Maintenance; Maintenances; Maps; Mediating; Membrane Potentials; Modeling; Models, Experimental; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocytes, Cardiac; Nerve Transmitter Substances; Neurotransmitters; Outcome; Patients; Pb element; Pharmacology, Clinical; Phosphorylation; Predisposition; Prevention; Program Development; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Public Health; Receptor Activation; Receptors, Epinephrine; Regulation; Research; Resting Potentials; Risk; Role; SNS; Scientist; Series; Staging; Sum; Susceptibility; Sympathetic Nervous System; Testing; Therapeutic; Training Programs; Translational Research; Translational Research Enterprise; Translational Science; Transmembrane Potentials; Ventricular Dysfunction, Left; Work; adenoreceptor; adrenergic; atrium; base; cardiac failure; cardiomyocyte; career; desensitization; design; designing; experiment; experimental research; experimental study; functional status; gene product; heavy metal Pb; heavy metal lead; high risk; improved; multidisciplinary; new therapeutics; next generation therapeutics; novel; novel therapeutics; prevent; preventing; programs; public health medicine (field); public health relevance; research study; skills; social role; therapeutic target; translation research enterprise; treatment strategy",Probing the Atrial Arrhythmogenic Substrate with Sustained Adrenergic Stimulation, PROJECT NARRATIVE Patients with heart failure are at an increased risk to develop atrial fibrillation which substantially contributes to their morbidity and mortality. This proposal is designed to positively impact public health by identifying therapeutic targets to prevent arrhythmias in the early stages of heart failure.,95655,ZHL1,Special Emphasis Panel,A1,1,138215,
7771275,K08,HL,1,,01/19/2010,11/30/2010,PA-09-042,1K08HL098373-01,,NHLBI:113689;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SCHILLING, JOEL DAVID;",9159464;,1K08HL098373,01/19/2010,11/30/2014,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; Active Oxygen; Address; Advisory Committees; Affect; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Area; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Breeding; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiology; Cardiomyopathies; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cause of Death; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cessation of life; Common Rat Strains; Complement; Complement Proteins; Coupled; Cytokines, Chemotactic; Death; Development; Diabetes Mellitus; Diet; Disease; Disorder; Doctor of Philosophy; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Echocardiogram; Echocardiography; Elements; Energy Expenditure; Energy Metabolism; Environment; Faculty; Fellowship; Functional disorder; Gene Expression; Gene Transcription; Generations; Genetic Transcription; Grant; Heart; Heart Diseases; Heart failure; Heart myocyte; Hexadecanoates; Homologous Chemotactic Cytokines; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Insulin Resistance; Intercrines; Intermediary Metabolism; Internal Medicine; Intracellular Communication and Signaling; Investigators; Knockout Mice; Knowledge; LPS; Lipids; Lipopolysaccharides; Lipoproteins; METBL; Mammals, Mice; Mammals, Rats; Manuscripts; Mediating; Mentors; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Modeling; Molecular; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Mycocardium Disease; Myocardial; Myocardial Diseases; Myocardial Disorder; Myocardial Infarct; Myocardial Infarction; Myocardiopathies; Myocardium; Myocytes; Myocytes, Cardiac; Nature; Neonatal; Nuclear Receptors; Null Mouse; Obesity; Organ System, Cardiovascular; Oxygen Radicals; Palmitates; Pathogenesis; Pathway interactions; Patients; Ph.D.; PhD; Phenotype; Physicians; Physiologic; Physiological; Physiopathology; Play; Principal Investigator; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; RNA Expression; RNA, Small Interfering; Rat; Rattus; Reactive Oxygen Species; Receptor Protein; Regulatory Pathway; Research; Research Personnel; Research Proposals; Researchers; Residencies; Role; SIS cytokines; STZ; Saturated Fatty Acids; Scientist; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Streptozocin; Streptozotocin; Stress; Structure; TIL4; TLR protein; TLR2; TLR2 gene; TLR4; TLR4 gene; TLR4 receptor; TOLL; Task Forces; Techniques; Testing; Tetracycline Antibiotic; Tetracyclines; Toll-4 receptor; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Training; Training Programs; Trans-Acting Factors; Trans-Activators; Transactivators; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Regulation; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Transplantation; Transthoracic Echocardiography; Universities; Vascular, Heart; Washington; Writing; Zanosar; adiposity; atheromatosis; atherosclerotic vascular disease; biological signal transduction; cardiac failure; cardiac infarct; cardiac metabolism; cardiac muscle; cardiomyocyte; cardiovascular disorder; career; chemoattractant cytokine; chemokine; circulatory system; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cytokine; defined contribution; diabetes; diabetic; diabetic cardiomyopathy; diabetic cardiopathy; diabetic cardiopathy disease; diabetic cardiopathy disorder; diabetic cardiovascular disease; diabetic cardiovascular disorder; diabetic patient; disease/disorder; fat metabolism; hToll; heart attack; heart disorder; heart infarct; heart infarction; heart metabolism; heart muscle; heart sonography; in vivo; inflammatory modulation; insight; insulin resistant; lipid metabolism; loss of function; mitochondrial; model organism; mouse model; myocardium disorder; novel; obese; obese people; obese person; obese population; pathophysiology; pathway; programs; public health relevance; receptor; receptor-mediated signaling; siRNA; skills; social role; sound measurement; toll-like receptor 4; trans acting factor (genetic); transgenic; transplant",Inflammatory-metabolic Crosstalk in the Myocardium," PROJECT NARRATIVE  Diabetes is an extremely common disease in the U.S. and the number of people with this disorder continues to grow. Patients with diabetes have higher rates of early death than patients without diabetes, largely due to heart disease. In addition heart attacks, diabetes also causes the heart muscle to weaken, leading to heart failure. It is not known precisely why patients with diabetes develop heart failure, but inflammation may play a key role. This proposal will evaluate how the inflammatory response affects the heart and how it may contribute to the heart failure that develops in diabetic patients.",98373,ZHL1,Special Emphasis Panel,,1,113689,
7660648,K22,AI,1,,02/01/2010,01/31/2011,PAR-07-347,1K22AI079388-01A1,,NIAID:162000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CLEVELAND,UNITED STATES,NONE,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"GRIMBERG, BRIAN ;",8196889;,1K22AI079388,02/01/2010,01/31/2012,"0-11 years old; ATGN; Accounting; Address; Affinity; Afghanistan; Age-Years; Alleles; Allelomorphs; Aminoacetic Acid; Antibodies; Antigen Presentation; Antigenic Determinants; Antigens; Area; Arm; Asia; Asia, Southeastern; Aspartic Acid; Assay; B-thalassemia; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Blood; Blood Group Antigens; Blood Sample; Blood Serum; Blood erythrocyte; Blood normocyte; Blood specimen; Brazil; Cell Surface Antigens; Cell surface; Child; Child Youth; Children (0-21); Cytofluorometry, Flow; Data; Development; East Indies; Elliptocytosis, Hereditary; Epidemiology; Epitopes; Erythrocytes; Erythrocytic; Federation of Malaya; Female; Flecks; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frequencies (time pattern); Frequency; Future; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genotype; Glycine; Grant; Grouping; Hemoglobin; Hereditary Elliptocytosis; Heterogeneity; Human; Human, Child; Human, General; In Vitro; Individual; Indonesia; Infection; Instruction; Interruption; Invaded; Iraq; Knowledge; L-Aspartic Acid; Laboratories; Laboratory Study; Latin America; Lead; Life; Life Cycle; Life Cycle Stages; Ligand Binding Protein; Location; Malaria; Malaria Vaccines; Malaria, Vivax; Malarial Vaccines; Malay Archipelago; Malay Federation; Malaya; Malaysia; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Measures; Membrane Proteins; Membrane-Associated Proteins; Microfluorometry, Flow; Microscopy; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mortality; Mortality Vital Statistics; Mutation; N-terminal; NH2-terminal; Netherlands East Indies; New Guinea, East; Observational Study; Oceania; Ovalocytosis, Hereditary; Paludism; Papua New Guinea; Parasites; Pathway interactions; Patients; Pb element; Phenotype; Plasmodium; Plasmodium Infections; Plasmodium knowlesi; Plasmodium vivax; Plasmodium vivax Malaria; Population; Predisposition; Process; Protein Binding; Receptor Protein; Recombinants; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reporting; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Risk; Rural; Sampling; Serum; Shapes; Sickle Cell; Southeast Asia; Southeastern Asia; Staging; Structure; Study of epidemiology; Surface; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Surface Proteins; Susceptibility; Symptoms; Testing; Thalassemia Major; Uncertainty; Upper arm; Vaccine Design; Vaccines; Variant; Variation; Vivax Malaria; WHO; World Health Organization; base; beta Thalassemia; blood corpuscles; cell type; children; conformation; conformational state; design; designing; disease characteristic; doubt; drepanocyte; epidemiology study; extracellular; flow cytophotometry; genome mutation; groupings; heavy metal Pb; heavy metal lead; immunogen; interest; life course; male; male group; men's group; ovalocytosis; p-Thalassemia; parasite invasion; pathogen; pathway; prevent; preventing; receptor; receptor expression; sex; sickle RBC; sickle erythrocyte; sickle red blood cell; simian plasmodia; southeast Asian; vaccine development; youngster",Duffy antigen presentation and its correlation to parasite invasion,,79388,MID,Microbiology and Infectious Diseases Research Committee,A1,1,162000,
7738640,K23,GM,1,,01/04/2010,12/31/2010,PA-05-143,1K23GM087534-01A1,,NIGMS:113740;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAINT LOUIS,UNITED STATES,ANESTHESIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"NAGELE, PETER ;",9347825;,1K23GM087534,01/04/2010,12/31/2013,"2-amino-4-mercaptobutyric acid; Acute; American; Anesthesia; Anesthesia procedures; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, General; Arm; Biological; Blinded; Butanoic acid, 4,4'-dithiobis(2-amino)-; Cardiac; Cardiac Death; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cardiac infarction; Causality; Chronic; Clinical Pharmacology; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Complement; Complement Proteins; Complex; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cyanocobalamin; Cyanocobalamin (Vitatmin B12); Death, Cardiac; Development Plans; Drug Therapy; Etiology; Event; Folate; Gene variant; General anesthetic drugs; Genes; Genetic; Genetic Determinism; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Homocysteine; Homocysteine, L-Isomer; Homocystine; Incidence; Inpatients; Investigation; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; K23 Award; K23 Mechanism; K23 Program; Laughing Gas; MTHFR; MTHFR gene; Master of Science; Measurement; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Mentorship; Metabolic Pathway; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Neurobion; Nitrogen oxide (N2O); Nitrous Oxide; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PBO; Patients; Perioperative; Pharmacogenetics; Pharmacology, Clinical; Pharmacotherapy; Placebos; Plans, Development; Polymorphism (Genetics); Polymorphism, Genetic; Position; Positioning Attribute; Post-Operative; Postoperative; Postoperative Period; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Publishing; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Controlled Trials; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk; Risk Factors; Role; Safety; Science of Medicine; Sham Treatment; Structure; Supplementation; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Testing; Therapeutic; TnI; Training; Translating; Translatings; Troponin I; Universities; Upper arm; VIT B12; Variant; Variation; Variation (Genetics); Vitamin B; Vitamin B 12; Vitamin B Complex; Vitamin B12; Vitamins; Washington; allelic variant; cardiac infarct; career; career development; clinical investigation; control trial; coronary attack; coronary infarct; coronary infarction; disease causation; disease etiology; disease/disorder etiology; disorder etiology; genetic determinant; genetic epidemiology; genetic risk factor; heart attack; heart infarct; heart infarction; heart ischemia; heart surgery; high risk; inherited factor; inhibitory troponin I; innovate; innovation; innovative; language translation; multidisciplinary; myocardial ischemia/hypoxia; myocardium ischemia; polymorphism; prevent; preventing; primary outcome; programs; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; sham therapy; social role; surgery; vitamin B12 compound",Perioperative pharmacogenetics:  Nitrous oxide and anesthetic outcomes,,87534,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1,1,113740,
7771307,K23,HD,1,,02/01/2010,01/31/2011,PA-09-043,1K23HD062637-01,,NICHD:112450;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CHARLESTON,UNITED STATES,NONE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"NEWMAN, SUSAN DUNREATH;",8831216;,1K23HD062637,02/01/2010,01/31/2015,"Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Accounting; Acute; Address; Adopted; Advocate; Affect; Analysis, Cost; Availability of Health Services; Bed Sores; Bedsore; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive; Communities; Community Participation; Competence; Cost Analyses; Cost Analysis; Data; Decision Making; Decubitus ulcer; Development; Development Plans; Education for Intervention; Educational Intervention; Environment; Environmental Factor; Environmental Risk Factor; Evaluation; Feasibility Studies; Focus Groups; Funding; Future; Goals; Health; Health Promotion; Health Services Accessibility; Independent Living; Individual; Inpatients; Instruction Intervention; Intervention; Intervention Strategies; Intervention Studies; Interview; Intracellular Communication and Signaling; Investigators; Length of Stay; Life; Living, Independent; Manuals; Measurement; Measures; Medical; Mentors; Mentorship; Methodology, Research; Methods; Modeling; Monitor; Myelopathy, Traumatic; NIH; National Institutes of Health; National Institutes of Health (U.S.); Number of Days in Hospital; Outcome; Outcome Measure; PROV; Participant; Participation, Community; Phase; Physical Health Services / Rehabilitation; Plans, Development; Pressure Sore; Pressure Ulcer; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Provider; QOL; Qualitative Methods; Quality of life; Randomized; Randomized Controlled Trials; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Reporting; Research; Research Design; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Salutogenesis; Sample Size; Services; Signal Transduction; Signal Transduction Systems; Signaling; Site; Social Environment; South Carolina; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Study Type; Testing; Time; Training; Training Intervention; Treatment Efficacy; UTI; United States National Institutes of Health; Universities; Urinary tract infection; Urinary tract infectious disease; Vulnerable Populations; Work; access to services; access to treatment; availability of services; base; biological signal transduction; career development; community based participatory research; community based service; community setting; cost; cost effectiveness; design; designing; disability; disease prevention; disorder prevention; dosage; eligible participant; environmental risk; evidence base; health care availability; health care service access; health care service availability; health disparities; health disparity; health services availability; healthcare access availability; healthcare service access; healthcare service availability; high risk; hospital days; hospital length of stay; hospital stay; improved; informant; instructional intervention; instrument; interventional strategy; member; novel; patient oriented research; patient oriented study; peer; programs; public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; rehabilitative; satisfaction; skills; social; social climate; social context; social role; socioenvironment; study design; therapeutic efficacy; therapeutically effective; treatment as usual",A Peer Navigator Intervention for Individuals with Spinal Cord Injury, PROJECT NARRATIVE This research addresses the recent NIH initiative to incorporate community-based participatory research approaches to more effectively research health issues of greatest relevance to high-risk communities and the National Health Promotion and Disease Prevention Objectives for 2020 to address the environmental factors that contribute to our health. Our strategy to address health promotion after spinal cord injury (SCI) moves beyond the level of the individual and incorporates an ecological approach to identify and address issues in the physical and social environment that influence health. We propose to adapt the role of the peer navigator to promote optimal outcomes after SCI by providing participants with the supports needed to reduce rehospitalizations and secondary conditions and maximize community participation and satisfaction with life after SCI.,62637,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,112450,
7807746,K23,HD,1,,01/15/2010,12/31/2010,PA-09-043,1K23HD063261-01,,NICHD:108391;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,GALVESTON,UNITED STATES,OBSTETRICS & GYNECOLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"VAN DEN BERG, PATRICIA AMY;",9614255;,1K23HD063261,01/15/2010,12/31/2014,"Active Follow-up; Address; Adolescent; Adolescent Youth; Analysis, Data; Area; Attitude; Award; Behavior; Binge Eating; Body Image; Body Weight decreased; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Categories; Child Nutrition; Cohort Studies; Concurrent Studies; Data Analyses; Development; Diabetes Mellitus; Diet; Discipline of obstetrics; Eating; Eating Disorders; Emesis; Ensure; Environment; Equilibrium; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Evaluation; Female; Female Adolescents; Food Intake; Goals; Gynecology; Height; High Prevalence; Hispanic Populations; Hispanics; Hispanics or Latinos; Hyperphagia; Intake; Intervention; Intervention Strategies; Interview; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; Latino Population; Lead; Leanness; Literature; Measures; Medical; Medicine; Mentors; Methods; Non-Hispanic; Not Hispanic or Latino; Nutrition; Nutrition Research; Nutrition, Child; Nutritional Science; Nutritional Study; Obesity; Obstetrics; Outcome; Over weight; Overeating; Overweight; Participant; Pb element; Physical activity; Predisposition; Preparation; Prevalence; Prevention program; Preventive Intervention; Programs (PT); Programs [Publication Type]; Public Health; Qualitative Research; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Training; Researchers; Risk; Risk Factors; Sampling; Schools; Science of Medicine; Science of nutrition; Spanish Origin; Students; Survey Instrument; Surveys; Susceptibility; TV; Television; Testing; Texas; Thinness; Time; Training; Underweight; Universities; Vomiting; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Weight maintenance regimen; Weights and Measures; Woman; adiposity; adolescent girl; balance; balance function; base; body dissatisfaction; body weight gain; body weight increase; body weight loss; career; college; compulsive eating; compulsive feeding; compulsive overeating; corpulence; corpulency; corpulentia; design; designing; diabetes; experience; follow-up; girls; heavy metal Pb; heavy metal lead; high school; hispanic community; improved; interventional strategy; juvenile; juvenile human; modifiable risk; novel; nutrition; obese; obese people; obese person; obese population; obesity prevention; patient centered; patient oriented; pediatric nutrition; peer; polyphagia; preventional intervention strategy; professor; programs; public health medicine (field); public health relevance; response; sedentary; sweetened beverage; weight control; wt gain; wt-loss",Unhealthy Weight Control Behaviors and Obesity In Hispanic and non-Hispanic Girls," Because both obesity and the use of unhealthy weight control attitudes and behaviors, such as excessive dieting and poor body image, are high among adolescents, there is a need to train new investigators in areas related to both of these problems. Further, studies in this area with adolescent girls from diverse backgrounds are limited. Advancing knowledge in this area will lead to improved obesity and disordered eating prevention interventions.",63261,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,108391,
7787843,K23,HL,1,,02/01/2010,01/31/2011,PA-09-043,1K23HL094532-01A1,,NHLBI:142871;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"KINDER, BRENT W;",8175336;,1K23HL094532,02/01/2010,01/31/2015,"Active Follow-up; American; Anaplastic; Applications Grants; Biochemical; Biological; Biostatistical Methods; Blood Serum; Bronchioalveolar Lavage; Bronchoalveolar Lavage; California; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cause of Death; Cessation of life; Characteristics; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Connective Tissue; Connective Tissue Diseases; Connective Tissue Disorder; Critical Care; Data; Death; Development; Diffuse; Disease; Disease Progression; Disorder; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Evolution; Forced Vital Capacity; Future; General Prognostic Factor; Goals; Grant Proposals; Grants, Applications; ILD; Infrastructure; Interstitial Lung Diseases; Investigation; Investigators; K-Awards; K-Series Research Career Programs; K23 Award; K23 Mechanism; K23 Program; Lavage, Bronchopulmonary; Longitudinal Studies; Lung; Lung Diseases, Interstitial; Lung Lavage; Lung diseases; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Molecular; Outcome; Patients; Physiologic; Physiological; Prognostic Factor; Prognostic/Survival Factor; Progressive Disease; Proteins; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Surfactant-Associated Protein A; Research; Research Career Program; Research Career Programs, K-Series; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Rheumatology; Risk Factors; SP-A Protein; San Francisco; Science of Medicine; Serologic; Serological; Serum; Surfactant Protein A; Undifferentiated; Universities; Vital capacity; Woman; Work; abstracting; biomarker; bronchopulmonary lavage therapy; career; clinical investigation; cohort; college; design; designing; disease/disorder; evidence base; follow-up; gene product; improved; long-term study; lung disorder; patient centered; patient oriented; professor; prospective; public health relevance; pulmonary; skills; surfactant",Undifferentiated Connective Tissue-associated Interstitial Lung Disease Cohort, Public health relevance: Improving our understanding of the disease course and outcome of the development of ILD in the setting of UCTD is critical to developing an evidence-base on which to design futures studies of this disease that disproportionately impacts young women during their peak working years.,94532,ZHL1,Special Emphasis Panel,A1,1,142871,
7787229,K23,MH,1,,01/15/2010,11/30/2010,PA-09-043,1K23MH085730-01A1,,NIMH:148462;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"DALRYMPLE, KRISTY LEE;",8517299;,1K23MH085730,01/15/2010,11/30/2014,"Address; Adherence; Adherence (attribute); Alcohol dependence; Anxiety; Anxiety Disorders; Area; Award; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Client satisfaction; Clinical; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Comorbidity; Competence; Complement; Complement Proteins; Conditioning Therapy; Data; Data Collection; Depression; Development; Diagnosis; Drug Therapy; Emotional Depression; Ethanol dependence; Ethics; Fostering; Functional impairment; Future; Goals; Grant; HOSP; Health Benefit; Hospitalization; Intervention; Intervention Strategies; Investigators; K-Awards; K-Series Research Career Programs; K23 Award; K23 Mechanism; K23 Program; Knowledge; Life; Life Style Modification; Maintenance; Maintenances; Major Depressive Disorder; Manuals; Manuscripts; Medical; Mental Depression; Mental Health; Mental Hygiene; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Mentorship; Methods; Methods and Techniques; Methods, Other; Modeling; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Out-patients; Outcomes Research; Outpatients; Patient Satisfaction; Patients; Pattern; Pharmacological Treatment; Pharmacotherapy; Phase; Pilot Projects; Population; Preparation; Prevalence; Procedures; Protocol; Protocols documentation; Protocols, Treatment; Psychiatry; Psychological Health; Psychotherapy; Public Health; Publishing; QOL; Quality of life; R01 Mechanism; R01 Program; RGM; RPG; Randomized; Regimen; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research, Outcomes; Researchers; Risk; Severities; Social Phobia; Strategic Planning; Suicide attempt; Symptoms; Symptoms of depression; Syndrome; Techniques; Technology; Testing; Training; Training Programs; Treatment Protocols; Treatment Regimen; Treatment Schedule; Treatment outcome; United States National Institute of Mental Health; Visit; Work; Writing; alcohol addiction; alcohol dependency; alcohol-dependent; base; behavior intervention; behavioral intervention; clinical investigation; combination therapy; combined modality treatment; combined treatment; depressive; depressive symptoms; design; designing; disability; early onset; ethanol addiction; ethanol dependency; ethanol-dependent; experience; functional disability; improved; improved functioning; innovate; innovation; innovative; intervention design; intervention development; interventional strategy; major depression; mindfulness; multimodality therapy; non fatal attempt; patient centered; patient oriented; pilot study; primary outcome; psychosocial; public health medicine (field); public health relevance; randomisation; randomization; randomized trial; randomly assigned; routine practice; secondary outcome; skills; social; suicidal attempt; therapy design; therapy development; treatment adherence; treatment design; treatment development; treatment response; treatment trial",Treatment Development for Comorbid Major Depression and Social Phobia," Project Narrative The proposed project will result in substantial public health benefit because it will be developed for and tested in a routine practice setting, where the prevalence of comorbid Major Depressive Disorder and Social Anxiety Disorder is highest and improved treatments for it are needed. In addition, the treatment will target overall functioning and quality of life as well as symptoms, and will be designed to augment pharmacotherapy, further increasing its public health impact.",85730,ITVA,,A1,1,148462,
7772421,K24,AR,1,,02/01/2010,01/31/2011,PA-09-037,1K24AR057827-01,,NIAMS:159723;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"LOSINA, ELENA ;",6781509;,1K24AR057827,02/01/2010,01/31/2015,"21+ years old; Abscission; Accident and Emergency department; Accuracy of Diagnosis; Active Follow-up; Address; Adult; Affect; Age-Years; Aged 65 and Over; Anesthesia, Epidural; Anesthesia, Extradural; Anesthesia, Peridural; Area; Arm; Arthritis; Arthritis, Degenerative; Arthroplasty, Replacement; Arthroplasty, Replacement, Knee; Arthroscopy; Articular Range of Motion; Articulation; Award; Behavioral Sciences; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Bone; Bone and Bones; Bones and Bone Tissue; Bypass; CDC; Caring; Causality; Censuses; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Study; Clinical Trials Design; Clinical effectiveness; Code; Coding System; Commit; Communities; Comorbidity; Complication; Computer Simulation; Computer-Aided Surgery; Computer-Assisted Surgery; Computerized Models; Computers; Controlled Clinical Trials, Randomized; Coupled; Coxa; Coxalgia; Critical Paths; Critical Pathways; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Debridement; Decision Making; Degenerative polyarthritis; Dependency; Dependency (Psychology); Development; Diagnosis; Diagnostic; Disease; Dislocations; Disorder; Doctor of Philosophy; Douching, other than vaginal; Drug usage; Drugs; Early Ambulation; Education; Educational aspects; Elderly; Elderly, over 65; Emergency Department; Emergency room; Enrollment; Ensure; Epidemic; Epidural Anesthesia; Epidural Block; Etiology; Evaluation; Event; Evidence based practice; Excision; Expenditure; Extirpation; FLR; Face; Faculty; Failure (biologic function); Fostering; Foundations; Frequencies (time pattern); Frequency; Functional impairment; Funding; Future; Goals; Grant; HOSP; Hand; Hand functions; Health; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Health Status; Hip; Hip Pain; Hip region structure; History; Holly; Hospitalization; Hospitals; Human, Adult; Incidence; Incontinence; Individual; Infection; Interdisciplinary Research; Interdisciplinary Study; International; Intervention; Intervention Strategies; Investigators; Irrigation; Irrigation, other than vaginal; Joint Dislocation; Joint Prosthesis Implantation; Joint Range of Motion; Joints; Knee Osteoarthritis; Knee Replacement, Total; Knee arthroplasty; Knee joint replacement operation; Knee replacement; Lavage; Lead; Level of Health; Life Expectancy; Life Tables; Ligaments; Longitudinal Studies; Low income; Lower Extremity; Lower Limb; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Manuscripts; Mathematical Model Simulation; Mathematical Models and Simulations; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Records; Medical Students; Medicare; Medication; Membrum inferius; Mentors; Methodology, Research; Methods; Methods and Techniques; Methods, Other; Minority; Modeling; Models, Computer; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multidisciplinary Collaboration; Multidisciplinary Research; Muscle; Muscle Tissue; Musculoskeletal; Musculoskeletal Diseases; NHANES; NMR Imaging; NMR Tomography; National Health and Nutrition Examination Survey; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Non obese; Nonobese; Nonvaginal irrigation; Nonvaginal lavage; Nuclear Magnetic Resonance Imaging; Obesity; Observational Study; Operation; Operative Procedures; Operative Surgical Procedures; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Osteoarthritis; Osteoarthritis, Knee; Osteoarthrosis; Outcome; Pain; Pain Control; Pain Therapy; Pain management; Painful; Participant; Patient Recruitments; Patient Self-Report; Patients; Pb element; Personal Satisfaction; Persons; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Health Services / Rehabilitation; Physicians; Policies; Policy Maker; Population; Post-Operative; Postdoc; Postdoctoral Fellow; Postoperative; Postoperative Period; Prevalence; Prevention; Prevention strategy; Preventive strategy; Probability; Procedures; Process; Programs (PT); Programs [Publication Type]; Prosthetic total arthroplasty of the knee; Public Health; Publications; QOL; Quality of life; Quality-Adjusted Life Years; R01 Mechanism; R01 Program; RPG; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Range of Motion, Articular; Recording of previous events; Recovery; Recruitments, Patient; Registries; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Removal; Replacement Arthroplasty; Reporting; Research; Research Associate; Research Design; Research Grants; Research Methodology; Research Methods; Research Personnel; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Research Support; Research Training; Researchers; Risk; Risk Factors; Role; Rotator Cuff; Rural; Sampling; Schools, Medical; Scientific Publication; Scientist; Self-Report; Services; Severity of illness; Simulate; Simulation, Computer based; Socio-economic status; Socioeconomic Status; Source; Staging; Status, Socioeconomic; Structure; Students; Students, Medical; Study Type; Study, Interdisciplinary; Surgeon; Surgery, Computer-Assisted; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survey Instrument; Surveys; Symptoms; TKR - Total knee replacement; Techniques; Technology; Tendon structure; Tendons; Testing; Time; Title 18; Total Arthroplasty of the Knee; Total Hip Replacement; Traineeship; Training; Training Programs; Treatment Cost; Treatment outcome; Trials, Randomized Clinical; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Upper arm; Using hands; Visit; Withdrawal; Woman; Work; Writing; Zeugmatography; adiposity; adult human (21+); advanced age; aged; arthritic; base; bone; career; clinical care; clinical data repository; clinical data warehouse; cohort; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; corpulence; corpulency; corpulentia; cost; cost effectiveness; data repository; degenerative joint disease; design; designing; diagnostic accuracy; disability; disease causation; disease etiology; disease severity; disease/disorder; disease/disorder etiology; disorder etiology; drug use; drug/agent; effective therapy; elders; emotional dependency; enroll; evidence base; experience; experiment; experimental research; experimental study; facial; failure; falls; follow-up; frailty; functional disability; functional outcomes; functional status; geriatric; health economics; health insurance for disabled; heavy metal Pb; heavy metal lead; high risk; hypertrophic arthritis; improved; in silico; injury prevention; innovate; innovation; innovative; instrument; interest; interventional strategy; irrigation therapy; joint replacement; late life; later life; lavage therapy; life time cost; lifetime cost; long-term study; medical schools; men; men's; minimally invasive; models and simulation; multidisciplinary; musculoskeletal disorder; new diagnostics; new technology; next generation; next generation diagnostics; novel; novel diagnostics; obese; obese people; obese person; obese population; older adult; older person; patient expectation; patient oriented research; patient oriented study; population based; post-doc; post-doctoral; preference; professor; programs; prospective; public health medicine (field); randomized controlled study; randomized trial; range of motion; rehabilitative; relational database; research study; resection; residence; response; rheumatologist; senior citizen; sham surgery; shared decision making; simulation; sober; sobriety; social role; standard of care; statistics/biometry; study design; success; surgery; systematic review; time use; tool; treatment strategy; virtual simulation; well-being; willingness; years of life lost",Patient Oriented Research and Mentoring Program in Orthopedics," The Mid-career Award in patient oriented research (K24) will enable me to dedicate a substantial portion of my time to pursue a robust program in patient oriented research in orthopaedics and to mentor young clinical scientists committed to orthopaedic and musculoskeletal patient oriented research. I highlight two research studies in this proposal: Study 1: To conduct a randomized controlled clinical trial to determine optimal timing for withdrawal of epidural anesthesia in patients undergoing total knee replacement. Study 2: To determine the diagnostic value of clinical history for the diagnosis of symptomatic meniscal tears in the presence of knee osteoarthritis (OA). Each of these studies, coupled with a comprehensive structured mentoring program, will help to address important unanswered questions in the management of patients with MSK disorders.",57827,AMS,Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee,,1,159723,
7771595,K24,HL,1,,01/29/2010,11/30/2010,PA-09-037,1K24HL098372-01,,NHLBI:156819;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"AUERBACH, ANDREW D;",6728972;,1K24HL098372,01/29/2010,11/30/2014,"2-(Acetyloxy)benzoic Acid; ACE Inhibitors; Acetylsalicylic Acid; Adrenergic beta-Antagonists; Affect; Angiotensin I-Converting Enzyme Inhibitors; Angiotensin-Converting Enzyme Inhibitors; Antagonists, Angiotensin-Converting Enzyme; Area; Aspergum; Aspirin; Cardiac; Cardiac Failure Congestive; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Congestive Heart Failure; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Data; Development; Drops; Drugs; Ecotrin; Empirin; Entericin; Extren; Faculty; Fostering; Goals; HOSP; Healthcare; Heart Decompensation; Heart Failure, Congestive; Hospitalists; Hospitalization; Investigators; K24 Award; Kininase II Antagonists; Kininase II Inhibitors; Measures; Measurin; Medication; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Mission; Morbidity; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; Patient Care; Patient Care Delivery; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Programs (PT); Programs [Publication Type]; QOC; Quality of Care; Quality of Health Care; Quality of Healthcare; Research; Research Personnel; Researchers; Specialist; Surgical; Surgical Interventions; Surgical Procedure; Translating; Translatings; Translations; Vascular, Heart; Work; abstracting; beta blocker; beta-Adrenergic Blocking Agents; beta-Adrenergic Receptor Blockaders; beta-Blockers, Adrenergic; cardiovascular disorder; care systems; career; circulatory system; drug/agent; health care quality; improved; interest; language translation; patient centered; patient oriented; patient oriented research; patient oriented study; programs; public health relevance; research to practice; surgery; systems of care",Improving management of cardiovascular medications during hospitalization," Relevance  This proposal is relevant to the mission of NHLBI as it aims to develop understanding of problems that have scientific and policy importance in the care of patients with coronary artery disease and congestive heart failure. Moreover, the mentorship program will develop researchers with a skillset that will be critical during an era which will place even greater priority on translation of evidence into practice.",98372,ZHL1,Special Emphasis Panel,,1,156819,
7771046,K99,AA,1,,02/01/2010,12/31/2010,PA-09-036,1K99AA018697-01,,NIAAA:89988;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHAPEL HILL,UNITED STATES,PSYCHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PARNELL, SCOTT ;",9756674;,1K99AA018697,02/01/2010,12/31/2011,"12-20 years old; 21+ years old; Absolute ethanol; Acute; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Adverse effects; Alcohol, Ethyl; Ammon Horn; Arts; Attention; Behavioral; Birth; Brain; Brain region; Cerebellum; Cognitive; Collaborations; Cornu Ammonis; Corpus Callosum; Corpus Callosums; Data; Defect; Development; Diagnosis; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease model; Dose; Dysmorphology; ETOH; Early Placental Phase; Effects, Longterm; Embryo; Embryonic; Encephalon; Encephalons; Environment; Ethanol; Exhibits; Exposure to; Eye; Eyeball; FASD; Fertility/Fertilization; Fertilization; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal ETOH Exposure; Fetal Ethanol Exposure; Fiber; First Pregnancy Trimester; Foundations; Future; Generalized Growth; Gestation; Goals; Goltz-Gorlin syndrome; Grain Alcohol; Growth; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; Image; Imaging Procedures; Imaging Techniques; Imaging technology; In Utero Alcohol Exposure; In Utero ETOH Exposure; In Utero Ethanol Exposure; Individual; Knowledge; Learning; Literature; Long-Term Effects; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mentorship; Methods; Methylcarbinol; Mice; Motor; Murine; Mus; NMR Imaging; NMR Tomography; NRVS-SYS; Nervous System; Nervous System, Brain; Nervous system structure; Neural Pathways; Neurologic Body System; Neurologic Organ System; North Carolina; Nuclear Magnetic Resonance Imaging; Parturition; Pathology; Pathway interactions; Pattern; Phenotype; Pregnancy; Pregnancy Trimester, First; Prenatal Alcohol Exposure; Prenatal ETOH Exposure; Prenatal Ethanol Exposure; Prevention; Reporting; Research; Research Specimen; Research Training; Resolution; Sensory; Severities; Solid; Specimen; Staging; Structure; Technics, Imaging; Testing; Time; Tissue Growth; Training; Treatment Side Effects; Trimester, First; Universities; Work; Zeugmatography; adolescence (12-20); adult human (21+); alcohol effect; alcohol exposed; alcohol exposure; alcohol-exposed pregnancy; alcoholic embryopathy; behavior test; behavioral test; biomarker; brain pathway; brain tract; career; design; designing; diffusion tensor imaging; disorder model; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol effect; ethanol exposed; ethanol exposure; experience; experiment; experimental research; experimental study; exposed to alcohol; exposed to alcohol prenatally; exposure to alcohol; fetal; fetal alcohol syndrome (FAS); gestation ETOH exposure; gestation alcohol exposure; gestation ethanol exposure; hippocampal; imaging; juvenile; juvenile human; mouse model; offspring; ontogeny; pathway; postnatal; pregnancy ETOH exposure; pregnancy alcohol exposure; pregnancy ethanol exposure; prenatal; prenatally alcohol exposed; prenatally exposed to alcohol; public health relevance; pup; research study; side effect; teenage; therapy adverse effect; treatment adverse effect; unborn",Neuroanatomical/Functional Correlates in an FASD Model, The experiments in this project will use MRI and behavioral tests to examine the effects of ethanol during early pregnancy in a mouse model of Fetal Alcohol Spectrum Disorders (FASD). The goal of this work is to increase our understanding of the spectrum of ethanol's effects in order to aid in the prevention and better diagnosis of FASD.  ,18697,AA,"Biochemistry, Physiology and Medicine Subcommittee",,1,89988,
7788630,K99,EY,1,,02/01/2010,01/31/2011,PA-09-036,1K99EY019547-01A1,,NEI:90000;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,GENETICS,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"KANADIA, RAHUL N;",8311718;,1K99EY019547,02/01/2010,01/31/2012,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 2PP2A; ATRA; Affect; All-trans retinoic acid; Alternate Splicing; Alternative Splicing; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antibodies; Aran-Duchenne disease; Architecture; Assay; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biological Models; Birth Order; Blotting, Northern; Body Tissues; Brain; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Central Nervous System; Central Nervous System Part; Code; Coding System; Codon, Nonsense; Codon, Termination, Premature; Complementary DNA; Complex; Cruveilhier disease; DNA; DNA, Complementary; Data; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Development; Diagnosis, Ultrasound; Disease; Disorder; Drosophila; Drosophila genus; Dystrophia Myotonica; Echography; Echotomography; Electroporation; Embryo; Embryonic; Encephalon; Encephalons; Engineering / Architecture; Event; Exclusion; Exons; Fluorescence; Fruit Fly, Drosophila; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome, Human; Glia; Glial Cells; GluR-B; Goals; HLA-DR Associated Protein II; House mice; Human; Human Genome; Human, General; I2PP2A; IGAAD; In Vitro; Infection; Inhibitor of GZMA-Activated DNase; Isoforms; Kanner's Syndrome; Knockout Mice; Kolliker's reticulum; Lead; Link; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Masks; Medical Imaging, Ultrasound; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Motor Cell; Motor Neurons; Murine; Mus; Mus musculus; Mutation; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neural Development; Neural Retina; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Nonsense Codon; Northern Blotting; Northern Blottings; Null Mouse; PHAPII; Pathogenesis; Pathway interactions; Pattern; Pb element; Phosphatase 2A Inhibitor I2PP2A; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Premature Stop Codon; Primary Senile Degenerative Dementia; Process; Protein Isoforms; Proteins; Proteome; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA Splicing; RNA Splicing, Alternative; RNA blot analysis; RNA blotting; RNA, Messenger; RNA, Non-Polyadenylated; RNAi; RT-PCR; RTPCR; Reporting; Research; Research Proposals; Resolution; Retina; Retina Proper; Retinal; Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Sequence-Specific Posttranscriptional Gene Silencing; Set protein; Spinal Muscular Atrophy; Splicing; Steinert Disease; Structure; TAF-IBETA; Techniques; Technology; Template Activating Factor I Beta; Tissues; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Vertebrate Animals; Vertebrates; Virus; Viruses, General; Vitamin A Acid; Work; all-trans-Retinoic Acid; all-trans-Vitamin A acid; base; cDNA; cell sorting; cell type; d-Numb; dementia of the Alzheimer type; design; designing; diagnostic ultrasound; disease/disorder; experiment; experimental research; experimental study; fruit fly; gain of function; gangliocyte; ganglion cell; gene product; genome mutation; glutamate receptor type B; heavy metal Pb; heavy metal lead; human fetal tissue; human fetus tissue; in vivo; injured; insight; interest; loss of function; mRNA; motoneuron; nerve cement; nervous system development; neural; neurodevelopment; neuronal; numb protein; pathway; postnatal; primary degenerative dementia; public health relevance; relating to nervous system; research study; retinal progenitor; retinal progenitor cell; retinal stem cell; reverse transcriptase PCR; senile dementia of the Alzheimer type; sex determination; sibling order; social role; sonogram; sonography; sound measurement; tool; trans-Retinoic Acid; ultrasound; ultrasound imaging; ultrasound scanning; vertebrata",The Role of Alternative Splicing Factor Sfrs10 in Neural Development," Project Narrative Understanding the role of alternative splicing in development is essential to our understanding the underlying mechanism that leads to diseases. There are several diseases such as Alzhiemer's disease, myotonic dystrophy, spinal muscular atrophy and autism that are linked to defects in alternative splicing of specific genes or are caused by mutations in genes that regulate the process of alternative splicing.",19547,ZEY1,Special Emphasis Panel,A1,1,90000,
7787792,K99,GM,1,,02/01/2010,01/31/2011,PA-09-036,1K99GM087551-01A1,,NIGMS:90000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PASADENA,UNITED STATES,ENGINEERING (ALL TYPES),29,009584210,US,CA,91125,CALIFORNIA INSTITUTE OF TECHNOLOGY,"LEWIS, JARED C;",8628525;,1K99GM087551,02/01/2010,01/31/2012,"Academia; Achievement; Achievement Attainment; Aerobic; Alkenes; Amaze; Amino Acids; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases; Amino Acyl-tRNA Synthetases; Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Synthetase; Anabolism; Binding; Binding (Molecular Function); Biological; Biological Factors; Biology; Boronic Acids; California; Catalysis; Chemicals; Collection; Complex; Crude Oil; Development; Development Plans; Diagnostic; Discipline; Drug Industry; E coli; Engineering; Engineerings; Ensure; Environment; Enzymes; Escherichia coli; Factor, Biologic; Faculty; Fostering; Genetic Engineering of Proteins; Goals; Health; Human; Human, General; Individual; Industry; Industry, Pharmaceutic; Institutes; Institution; Ions; L-Tryptophan; Laboratories; Levotryptophan; Life; Man (Taxonomy); Man, Modern; Medical; Mentors; Mentorship; Metabolic; Metabolic Pathway; Metals; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Natural Products; Nature; Olefins; Organic Solvents; Organic Synthesis; Organic solvent product; Organism; Palladium; Pathway interactions; Pd element; Peptides; Petroleum; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Physiologic; Physiological; Plans, Development; Preparation; Procedures; Production; Protein Engineering; Proteins; Public Health; Reaction; Reagent; Research; Ribonucleic acids, transfer; Scaffolding Protein; Science; Scientist; Side; Site; Specificity; Speed; Speed (motion); System; System, LOINC Axis 4; Technology; Transfer RNA; Transfer RNA Synthetase; Transition Elements; Triplet Codon-Amino Acid Adaptor; Tryptophan; Work; Writing; aminoacid; aminoacid tRNA ligase; application in practice; aqueous; aryl halide; biosynthesis; career development; catalyst; chemical reaction; chemical synthesis; conformation; conformational state; design; designing; directed evolution; experience; gene product; improved; in vivo; living system; member; metalloenzyme; novel; pathway; petroleum oil; practical application; professor; public health medicine (field); public health relevance; success; tRNA; tRNA Synthetase; transition metal; trend",Transition Metal Catalysis and Metabolic Engineering using Artificial Metalloenzy, The research outlined in this proposal has the potential to greatly improve public health by creating a new class of artificial metalloenzymes for the synthesis biologically active molecules. This platform will enable inclusion of powerful transition metal catalysts in metabolic pathways in unprecedented fashion in order to efficiently produce chemicals in vivo.,87551,ZGM1,Special Emphasis Panel,A1,1,90000,
7770569,K99,GM,1,,01/15/2010,12/31/2010,PA-09-036,1K99GM089826-01,,NIGMS:85752;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"MARTIN, ADAM CHRISTOPHER;",6729530;,1K99GM089826,01/15/2010,12/31/2011,"Ablation; Abnormal Cell; Actin Filaments; Actins; Actomyosin; Apical; Architecture; Automobile Driving; Biochemical; Biochemistry; Biology; Body Tissues; Cancers; Cell Communication and Signaling; Cell Shape; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Matrix; Cellular biology; Chemistry, Biological; Complex; Cone; Cones (Eye); Cones (Retina); Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Data; Development; Developmental Cell Biology; Drivings, Automobile; Drosophila; Drosophila genus; Drugs; Education; Educational aspects; Electromagnetic, Laser; Engineering / Architecture; Environment; Epithelial; Epithelial Cells; Epithelium; Expertise, Technical; Foundations; Fruit Fly, Drosophila; Future; Gene Expression; GeneHomolog; Generations; Genes; Genetic; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; Image Analyses; Image Analysis; Individual; Intracellular Communication and Signaling; Lasers; Learning; Life; Locomotor Activity; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Math Models; Measures; Mechanics; Medication; Mentors; Mesoderm Cell; Mesodermal Cell; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Microfilaments; Modeling; Molecular; Morphogenesis; Motor Activity; Myofilaments; Myosin II; Myosin Type II; Neoplasm Metastasis; Organ; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Photobleaching; Photoreceptors, Cone; Physics; Physiologic pulse; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postdoc; Postdoctoral Fellow; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Property; Property, LOINC Axis 2; Proteins; Pulse; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; ROC Analysis; Radiation, Laser; Regulation; Research; Research Associate; Research Resources; Resources; Retinal Cone; Role; Running; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Snails; Stretching; System; System, LOINC Axis 4; Technical Expertise; Testing; Time; Tissues; Training; Translating; Translatings; Tumor Cell; Tumor Cell Migration; Universities; Variant; Variation; Work; biological signal transduction; cancer cell; cancer metastasis; cancer progression; cell behavior; cell biology; cell growth; cell imaging; cellular imaging; cone cell; constriction; driving; driving force; drug/agent; experience; experiment; experimental research; experimental study; fruit fly; gastrulation; gene product; graduate student; image evaluation; improved; insight; interdisciplinary approach; intracellular skeleton; language translation; malignancy; mathematical model; mathematical modeling; multidisciplinary; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new therapeutic target; photoactivation; post-doc; post-doctoral; prevent; preventing; prospective; protein function; public health relevance; research study; skills; social role; transcription factor; tumor progression",Investigating the molecular and mechanical regulation of pulsed actomyosin contra," 7. Project Narrative During development and cancer progression, gene expression induces mechanical changes in cells that result in changes in cell shape and tissue architecture. We will investigate the function of two genes that promote cell shape changes during the development of the fruit fly, and whose human homologues are involved in cancer cell metastasis. We will investigate how these genes generate forces in cells and tissues and whether the mechanical forces in a tissue regulate individual cell behavior.",89826,ZGM1,Special Emphasis Panel,,1,85752,
7772503,K99,GM,1,,01/11/2010,12/31/2010,PA-09-036,1K99GM089985-01,,NIGMS:89980;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"SATTELY, ELIZABETH SUSAN;",9164349;,1K99GM089985,01/11/2010,12/31/2010,"Acetonitriles; Anabolism; Antiparasitic Agents; Antiparasitic Drugs; Antiparasitics; Arabidopsis; Area; Assay; Auxins; Bio-Informatics; Bioassay; Biochemistry; Biogenesis; Bioinformatics; Biologic Assays; Biological Assay; Biological Factors; Broccoli; Broccoli - dietary; C element; Carbon; Chemicals; Chemistry; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Closure by Ligation; Collaborations; Complex; Consult; Cyanomethanes; Cysteine; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Data; Development; Drug Formulations; Ecology; Educational workshop; Endocrine Gland Secretion; Environmental Science; Enzymatic Biochemistry; Enzymes; Enzymology; Ethane Nitriles; Factor, Biologic; Formulation; Formulations, Drug; Foundations; Genes; Genetic; Glucosinolates; Half-Cystine; Health; Hormones; Host Defense; Human; Human, General; Hydroxylases; Immune response; Indoles; Intermediary Metabolism; Investigation; Kale; Kale - dietary; L-Cysteine; Ligation; METBL; Man (Taxonomy); Man, Modern; Medicine; Mentors; Metabolic Processes; Metabolism; Methods; Methyl Cyanides; Mixed Function Oxidases; Mixed Function Oxygenases; Molecular; Monooxygenases; Natural Products; Origin of Life; Orphan; P450; Parasiticides; Pathway interactions; Phase; Plant Components; Plant Model; Plant Structures; Plants; Plants, General; Prevalence; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Recombinants; Research; Research Proposals; Role; Route; Science of Chemistry; Science of Medicine; Stress; System; System, LOINC Axis 4; Therapeutic Hormone; Training; Vegetables; Work; Workshop; anti-microbial; antimicrobial; biological adaptation to stress; biosynthesis; broccoli sprout; defense response; dietary vegetable; enzyme pathway; host response; immunoresponse; interdisciplinary approach; measurement of metabolism; meetings; member; metabolomics; pathogen; pathway; phytoalexin; phytoalexins; programs; public health relevance; reaction; crisis; skills; small molecule; social role; stress response; stress; reaction; ward",Biosynthesis of Indolic Phytoalexins: Mechanisms of Plant Innate Immune Response," ¨ Project Narrative Plants produce a wealth of secondary metabolites for defense against destructive pests. The research program outlined in this proposal explores components of plant immune response pathways as well as the production, distribution, and metabolism of the contributing small molecules. These compounds are contained in commonly consumed vegetables and have been found to have beneficial effects on human health.",89985,ZGM1,Special Emphasis Panel,,1,89980,
7772531,K99,GM,1,,01/15/2010,12/31/2010,PA-09-036,1K99GM089987-01,,NIGMS:87074;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,050299031,US,TX,770051892,RICE UNIVERSITY,"STRADER, LUCIA ;",9755554;,1K99GM089987,01/15/2010,12/31/2011,"2,4-Pentadienoic acid, 5-(1-hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-, (S-(Z,E))-; 3-indolylacetic acid; Abscisic Acid; Abscissic Acid; Abscissins; Abscission; Affinity Chromatography; Agriculture; Arabidopsis; Arabidopsis thaliana; Area; Auxins; Binding; Binding (Molecular Function); Biochemical; Biochemical Genetics; Blood Vessels; Cell Communication and Signaling; Cell Signaling; Cell division; Characteristics; Chemotherapy-Hormones/Steroids; Chromatography, Affinity; Complement; Complement Proteins; Cress, Mouse-ear; DISSEC; Development; Dissection; EC 2.7.2-; Embryo Development; Embryogenesis; Embryonic Development; Endocrine Gland Secretion; Environment; Ethylenes; Excision; Exhibits; Extirpation; Extracellular Signal-Regulated Kinases; Fruit; Gene Transcription; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic Research; Genetic Transcription; Genetic defect; Genetic, Biochemical; Germination; Goals; Growth; Growth and Development; Growth and Development function; Hormones; IES cpd; Intracellular Communication and Signaling; Knowledge; Learning; Lesion; MAP kinase; MAPK; MAPK Signaling Pathway; MAPK Signaling Pathway Pathway; Mentors; Mitogen-Activated Protein Kinases; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mouse-ear Cress; Mutation; Nature; Pathway interactions; Peptide Biosynthesis, Ribosomal; Perception; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phytohormones; Plant Embryos; Plant Growth Regulators; Plant Hormones; Plant Leaves; Plant Model; Plant Roots; Plants; Plants, General; Postdoc; Postdoctoral Fellow; Principal Investigator; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Synthesis, Ribosomal; Protein phosphatase; Proteins; RNA Expression; Regulation; Removal; Reporter; Repressor Proteins; Research; Research Associate; Research Resources; Research Training; Resistance; Resources; Rice; Role; Saline; Saline Solution; Seeds; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Soil; Specificity; Stress; Students; Surgical Removal; Testing; Therapeutic Hormone; Time; Tissue Growth; Training; Transcription; Transcription, Genetic; Universities; Zygotes, Plant; affinity purification; agricultural; base; beta-indoleacetic acid; biological adaptation to stress; biological signal transduction; career; dietary fruit; experiment; experimental research; experimental study; gene product; genome mutation; indole acetic acid; indole-3-acetic acid; indoleacetic acid; indolyl-3-acetic acid; insight; leaf; mutant; novel; ontogeny; pathway; positional cloning; post-doc; post-doctoral; protein synthesis; public health relevance; reaction; crisis; research study; resection; resistant; response; reverse genetics; root; seed; senescence; social role; stress response; stress tolerance; stress; reaction; tool; vascular",Using Arabidopsis to uncover interactions between phytohormone signaling pathways," PROJECT NARRATIVE - INTERACTION OF PHYTOHORMONE SIGNALING  PATHWAYS Auxin, abscisic acid, and ethylene are three plant hormones controlling many aspects of growth and development, such as growth responses, stress tolerance, and fruit ripening. Understanding of the signaling interactions between theses phytohormones, in addition to contributing to the general knowledge of how these hormones act, may provide insight for the eventual improvement of agriculturally- and medicinally-important plants. For instance, determining how to increase stress tolerance (ABA perception) without altering growth characteristics (auxin perception) or ripening (ethylene perception) could be key to adapting crops to high stress areas (i.e., areas of low rainfall or saline soils).",89987,ZGM1,Special Emphasis Panel,,1,87074,
7787941,K99,HD,1,,02/01/2010,01/31/2011,PA-09-036,1K99HD060762-01A1,,NICHD:96570;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BATON ROUGE,UNITED STATES,NONE,06,611012324,US,LA,70808,LSU PENNINGTON BIOMEDICAL RESEARCH CTR,"REDMAN, LEANNE MAREE;",8926389;,1K99HD060762,02/01/2010,07/31/2011,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; Aerobic; Aerobic Activity; Aerobic Exercise; Affect; Age; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Aquadiol; Award; Bioavailable; Blood Serum; Body Weight; Body Weight Changes; Body Weight decreased; Cannot achieve a pregnancy; Causality; Clamping, Glucose; Clinical Research; Clinical Study; Communities; Control Groups; Controlled Clinical Trials, Randomized; Cyclicity; D-His-6-Pro-8-NEt-LHRH; Data; Delta4-androsten-17beta-ol-3-one; Development; Difficulty conceiving; Dimenformon; Dimethylbiguanidine; Dimethylguanylguanidine; Diogyn; Diogynets; Disease; Disorder; Dysfunction; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Etiology; Euglycaemic Clamp; Euglycemic Clamping; Evidence based treatment; Exercise; Exercise, Physical; FSH; FSH-Releasing Hormone; Fasting; Fecundability; Fecundity; Female; Fertility; Follicle Stimulating Hormone; Follitropin; Functional disorder; Glucose Clamp; GnRH (gonadotropin releasing hormone); Gonadoliberin; Gonadorelinum; Gonadotropin Hormone Releasing Hormone; Gonadotropin-Releasing Hormone; Hoe- 471; Hormonal; Humulin R; Hyperinsulinemia; Hyperinsulinism; Imidodicarbonimidic diamide, N,N-dimethyl-; Infertility; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Interstitial Cell Stimulating Hormone; Interstitial Cell-Stimulating Hormone; Intervention; Intervention Strategies; LH-FSH Releasing Hormone; LH-Releasing Hormone; LHFSH Releasing Hormone; Lead; Leuteinizing Hormone; Life Style; Lifestyle; Luliberin; Luteinizing Hormone; Luteinizing Hormone-Releasing Factor; Luteinizing Hormone-Releasing Hormone; Luteinizing hormone-releasing factor (pig); Lutropin; Master of Science; Measures; Mediating; Metformin; Modification; Morphology; Muscle Cells; Muscle Cells, Mature; Myocytes; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Novolin R; Obesity; Ovarian; Over weight; Overweight; Ovocyclin; Ovocylin; Ovulation; Patients; Pb element; Periodicity; Phase; Physiopathology; Pilot Projects; Pituitary Lutenizing Hormone; Polycystic Ovarian Disease; Polycystic Ovary Syndrome; Pre-Menopause; Pre-menopausal Period; Premenopausal; Premenopausal Period; Premenopause; Prevalence; Production; Programs (PT); Programs [Publication Type]; Progynon; Publishing; Pulsti; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Recombinant Gonadorelin; Recombinant Luteinizing Hormone; Relative; Relative (related person); Reproductive Endocrinology; Rhythmicity; Sclerocystic Ovarian Degeneration; Sclerocystic Ovary Syndrome; Serum; Sex Hormone-Binding Globulin; Sex Steroid-Binding Protein; Stein Lenventhal syndrome; Stein-Leventhal Syndrome; Steroid Compound; Steroids; Syndrome; Testosterone; Testosterone-Estradiol Binding Globulin; Therapeutic Androgen; Therapeutic Estradiol; Therapeutic GRH; Therapeutic LH; Therapeutic Testosterone; Training; Trans-Testosterone; Universities; Weight; Weight Change; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Woman; adiposity; body weight gain; body weight increase; body weight loss; corpulence; corpulency; corpulentia; diet and exercise; diet restriction; dietary restriction; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; fasted; fasts; follicle stimulating hormone-releasing factor; glucose disposal; gonadotropin releasing factor; granulosa cell; heavy metal Pb; heavy metal lead; improved; infertile; insulin sensitivity; insulin sensitizer; insulin sensitizing drugs; insulin stimulated glucose disposal; interventional strategy; obese; obese people; obese person; obese population; pathophysiology; pilot study; polycystic ovary; polycystic ovary disease; polycystic ovary disorder; pre-menopausal; programs; public health relevance; randomized controlled study; randomized trial; reproductive; reproductive function; restricted diet; translational study; treatment program; unable to bear children; wt gain; wt-loss",Effects of weight and insulin sensitivity on reproductive function in PCOS, Polycystic ovary syndrome (PCOS) is the most common reproductive abnormality in premenopausal  women. The prevalence of PCOS in the community is increasing in parallel with the rise in obesity.  Weight loss by regular exercise and dieting is currently recommended in the treatment of the syndrome.  The ability of these treatments to restore menstrual function and fertility in some women is not known. ,60762,CHHD,National Institute of Child Health and Human Development Initial Review Group,A1,1,96570,
7764277,P01,HL,1,,01/19/2010,12/31/2010,,1P01HL092870-01A1,,NHLBI:2330347;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BLACKWELL, TIMOTHY S;",1920895;,1P01HL092870,01/19/2010,12/31/2014,,Mechanisms of Familial Pulmonary Fibrosis,,92870,HLBP,"Heart, Lung, and Blood Program Project Review Committee",A1,1,2330347,
7860827,P20,HL,1,,04/01/2010,03/31/2011,HL-10-001,1P20HL101397-01,,NHLBI:604473;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"LIMA, JOAO A C;",1920115;,1P20HL101397,04/01/2010,03/31/2012,,PRIMARY ECG - MRI RISK STRATIFICATION,,101397,ZHL1,Special Emphasis Panel,,1,604473,
7867074,P20,HL,1,,01/15/2010,12/31/2010,HL-10-001,1P20HL101438-01,,NHLBI:741860;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,,09,086987831,US,TX,772250345,TEXAS HEART INSTITUTE,"GREGORIC, IGOR  (contact);KAR, BISWAJIT ;PERIN, EMERSON CARVALHO;",9860364;9949541 (contact);9957576;,1P20HL101438,01/15/2010,12/31/2011,,Combined Stem Cell and Assist Device Therapy for Heart Failure,,101438,ZHL1,Special Emphasis Panel,,1,741860,
7867220,P20,HL,1,,04/01/2010,03/31/2011,HL-10-001,1P20HL101443-01,,NHLBI:764867;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MIAMI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"HARE, JOSHUA M;",1897640;,1P20HL101443,04/01/2010,03/31/2012,,Autologous Adult Myocardial Cardioblasts to Treat Ischemic Heart Failure,,101443,ZHL1,Special Emphasis Panel,,1,764867,
7867658,P20,HL,1,,04/01/2010,03/31/2011,HL-10-001,1P20HL101820-01,,NHLBI:653504;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"LEVY, ROBERT J;",1874844;,1P20HL101820,04/01/2010,03/31/2012,,TGA-ethanol Pretreated Bovine Pericardium for the Norwood Procedure,,101820,ZHL1,Special Emphasis Panel,,1,653504,
7793298,R01,AA,1,,01/04/2010,12/31/2010,PA-07-070,1R01AA018153-01A2,,NIAAA:330466;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BELMONT,UNITED STATES,,07,046514535,US,MA,02478,"MC LEAN HOSPITAL (BELMONT, MA)","SILVERI, MARISA M;",6886701;,1R01AA018153,01/04/2010,12/31/2014,"12-20 years old; 2-Hydroxy-N,N,N-trimethylethanaminium; 21 year old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Adolescence; Age; Age-Years; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic; Alcohols; Aminalon; Aminalone; Anterior; Area; Boozer; Brain; Brain region; Butanoic acid, 4-amino-; California; Cerebrum; Chemical Class, Alcohol; Chiro-Inositol; Choline; Clinical; Cognition; Cognitive; Data; Decision Making; Dependence; Dependent drinker; Detection; Development; Dysfunction; Encephalon; Encephalons; EtOH drinking; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethanol dependence; Female; Functional disorder; Future; GABA; Glutamates; H+ element; Hydrogen Ions; Impulsive Behavior; Impulsivity; Inositol; L-Glutamate; Learning; Light; Literature; MR Spectroscopy; MRS; MRSI; Magnetic Resonance; Magnetic Resonance Spectroscopy; Measures; Mediating; Memory; Mesoinositol; Methods; Methods and Techniques; Methods, Other; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; Nervous System, Brain; Neurobiology; Occipital lobe; Parietal; Pattern; Performance; Photoradiation; Physiopathology; Population; Prefrontal Cortex; Prevalence; Prospective Studies; Protons; Relative; Relative (related person); Reporting; Research; Risk Factors; Sex Characteristics; Sex Differences; Staging; Techniques; Testing; Time; Verbal Learning; Work; adolescence (12-20); adult youth; alcohol addiction; alcohol dependency; alcohol effect; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; association cortex; binge alcohol consumption; binge drinking; cingulate cortex; cognitive function; cohort; design; designing; drinking; emerging adulthood; episodic drinking; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol use disorder; ethanol-dependent; etoh use; executive control; executive function; frontal cortex; frontal lobe; gamma-Aminobutyric Acid; gender difference; hazardous alcohol use; interest; magnetic field; male; morris water maze; morris watermaze; neurobiological; neuropsychological; novel; occipital cortex; pathophysiology; problem drinker; problem drinking; public health relevance; response; sex; sexual dimorphism (noncellular); teenage; twenty-one year old; young adult",Neurobiological consequences of binge alcohol consumption in young adults," The overall aim of our proposed study is to examine the effects of binge alcohol consumption on brain metabolites in 18-24 year subjects by applying magnetic resonance spectroscopy (MRS) single voxel methods to reliably detect and quantify GABA, glutamate, and other proton metabolites, in the anterior cingulate region of the prefrontal cortex at 4 Tesla. Spectroscopic data will be examined relative to cognitive performance, with a focus on executive functioning, a frontally mediated area of cognition most widely reported to show deficits in alcohol use disorders. The results of this study will have significant relevance for public health concern, as identification of neurobiological correlates associated with binge alcohol consumption during ""emerging adulthood"" will help fill a gap in the existing literature on brain alcohol effects in a population that demonstrates not only the highest rate of binge drinking, but also the highest rate of alcohol abuse and dependence.",18153,NAL,Neurotoxicology and Alcohol Study Section,A2,1,330466,
7793038,R01,AA,1,,02/01/2010,01/31/2011,PA-07-070,1R01AA018335-01A1,,NIAAA:325063;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHAPEL HILL,UNITED STATES,NEUROLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MALANGA, C J;",6972130;,1R01AA018335,02/01/2010,01/31/2014,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Address; Administration, Oral; Agonist; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic Beverages; Alcoholism; Alcohols; American; Americas; Amphetamines; Animals; Behavior; Behavioral; Biological; Blood Alcohol Content; Blood alcohol level measurement; Brain; Cell Communication and Signaling; Cell Signaling; Chemical Class, Alcohol; Chemosensitization; Chemosensitization/Potentiation; Chronic; Cocaine; Complex; Consumption; D2 receptor; DBA/2 Mouse; DRD2; DRD2 Receptor; Data; Development; Dietary Alcohol; Disease; Disorder; Dopamine; Dopamine Agents; Dopamine D2 Receptor; Dopamine Drugs; Dopaminergic Agents; Dopaminergic Drugs; Dose; Drug Administration, Oral; Drug Kinetics; Drugs; Encephalon; Encephalons; EtOH drinking; Ethanol dependence; Genetic; Gustation; Heavy Drinking; Hydroxytyramine; Impairment; Inbred Strains Mice; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Laboratories; Lead; Mammals, Mice; Measures; Mediating; Medication; Methods; Mice; Mice, Inbred Strains; Motivation; Mouse Strains; Murine; Mus; Nervous System, Brain; Nicotine; Opiates; Oral; Oral Administration; Outcome; Pain; Painful; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phase; Potentiation; Property; Property, LOINC Axis 2; Public Health; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Receptor Protein; Regulation; Rewards; Risk; Rodent Model; Role; Science; Self Administration; Self Stimulation; Self-Administered; Signal Transduction; Signal Transduction Systems; Signaling; Sound; Sound - physical agent; System; System, LOINC Axis 4; Taste; Taste Perception; Testing; Thirst; Time; Translating; Translatings; United States; Withdrawal; addiction; alcohol addiction; alcohol dependency; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol reward; alcohol sensitivity; alcohol use; alcohol use disorder; alcohol withdrawal; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; base; biological signal transduction; blood alcohol concentration; blood alcohol level; cost; disease/disorder; drink heavily; drinking; drug/agent; effective therapy; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol reward; ethanol sensitivity; ethanol use; ethanol use disorder; ethanol withdrawal; ethanol-dependent; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; extreme drinking; falls; genetic strain; hazardous alcohol use; heavy alcohol use; heavy metal Pb; heavy metal lead; insight; interventional strategy; intraoral drug delivery; language translation; mouse model; neural circuit; neural circuitry; new approaches; new therapeutic target; novel approaches; novel strategies; novel strategy; pathway; problem drinking; public health medicine (field); public health relevance; receptor; reinforcer; research study; sensitivity to alcohol; sensitivity to ethanol; social; social role; sound; withdrawal from alcohol",Effects of Acute and Chronic Alcohol on Brain Reward in Mice," PROJECT NARRATIVE The behavioral and biological problems of alcohol abuse begin with the pleasurable or rewarding effects of alcohol use. Alcohol use disorders are a major public health problem, costing American taxpayers almost $200 billion each year. The development of new and effective treatments based on sound neuroscientific evidence is critical to address the pain and impairment these disorders bring to the nearly 10 million people who suffer from them in the United States of America.",18335,NAL,Neurotoxicology and Alcohol Study Section,A1,1,325063,
7782044,R01,AG,1,,02/01/2010,01/31/2011,PA-07-070,1R01AG031774-01A1,,NIA:340300;,2010,NATIONAL INSTITUTE ON AGING,,BRONX,UNITED STATES,PHARMACOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CAI, DONGSHENG ;",9767917;,1R01AG031774,02/01/2010,01/31/2015,"Address; Affect; Age; Aging; Aging Process; Aging-Related Process; Body Tissues; Brain; C57BL/6 Mouse; Caloric Restriction; Calories; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Data; Development; Disease; Disorder; Disturbance in cognition; EC 2.7; Encephalon; Encephalons; Family; Food; Gene Transfer; Genetic; Goals; Health; Hypothalamic structure; Hypothalamus; IKBKB; IKK 2 kinase; IKK beta; INFLM; IkappaB kinase beta; Immunoglobulin Enhancer-Binding Protein; Impaired cognition; Inflammation; Inflammatory; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Knowledge; Lead; Lentivirinae; Lentivirus; Mammals, Mice; Mediating; Metabolic; Metabolic Pathway; Mice; Modification; Molecular; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nutrition; Nutritional; Nutritional Science; Outcome; Oxidative Stress; Pathway interactions; Pb element; Phosphotransferases; Physiologic; Physiological; Programs (PT); Programs [Publication Type]; Reaction; Reporter; Research; Role; Science of nutrition; Senescence; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subfamily lentivirinae; Sum; System; System, LOINC Axis 4; Testing; Tissues; Transcription Factor NF-kB; Transgenic Organisms; Transphosphorylases; Virus-Lenti; Work; age dependent; age effect; age related; aging effect; anti aging; anti aging drug; anti aging medicine; antiaging; antiaging drug; antiaging medicine; base; biological signal transduction; body sense; calorie (nutrition); calorie restriction; cognitive dysfunction; cognitive loss; cognitively impaired; combat; disease/disorder; experiment; experimental research; experimental study; food restriction; heavy metal Pb; heavy metal lead; hypothalamic; interest; kappa B Enhancer Binding Protein; molecular marker; mouse model; neural; neuronal; nuclear factor kappa beta; nutrition; pathway; programs; public health relevance; relating to nervous system; research study; senescent; social role; success; transcription factor; transfer of a gene; transgenic",Role of Hypothalamic IKK-beta/NF-kappaB in Nutritional Control of Aging," NARRATIVE The development of aging and aging-related diseases involves body's progressive formation of oxidative stress and inflammation, a deleterious reaction that can be induced by calories from consumed food, and conversely, aging has been shown to be slowed down by caloric (food) restriction. Because the hypothalamus in the brain is the headquarters for sensing body's nutritional (calorie) status, and because an inflammatory pathway in the hypothalamus can respond to nutritional signals and affect hypothalamic functions, this project will investigate whether and how this inflammatory pathway in the hypothalamus mediates the nutritional actions on aging. Success of this study will advance our knowledge about how nutrition is involved in the development of aging and aging-related diseases, and provide broad new strategies to combat aging-related diseases.",31774,CMAD,Cellular Mechanisms in Aging and Development Study Section,A1,1,340300,
7781226,R01,AG,1,,02/01/2010,01/31/2011,PA-07-070,1R01AG032333-01A2,,NIA:368385;,2010,NATIONAL INSTITUTE ON AGING,,BAR HARBOR,UNITED STATES,,02,042140483,US,ME,046091500,JACKSON LABORATORY,"HARRISON, DAVID E;",1882092;,1R01AG032333,02/01/2010,01/31/2015,"21+ years old; ACRP30 protein; AMP Kinase; ATP-AMP Phosphotransferase; ATP-AMP Transphosphorylase; Active Follow-up; Adenylokinase; Adipocytes; Adipose Cell; Adipose tissue; Adult; Age; Age-Months; Aged 65 and Over; Aging; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Birds of Prey; Blood Pressure, High; Blotting, Western; Body Composition; Body Tissues; Body fat; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cachectin; Cachectin-Tumor Necrosis Factor; Categories; Cell Communication and Signaling; Cell Signaling; Cell Size; Cessation of life; Childhood; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; D-Glucose; DISSEC; Data; Death; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Differentiation Factor, B-Cell; Disease; Disorder; Dissection; Drug or chemical Tissue Distribution; EMI scan; Elderly; Elderly, over 65; Electron Transport; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fasting; Fat Cells; Fats; Fatty Acids, Nonesterified; Fatty Tissue; Fatty acid glycerol esters; Food; Free Fatty Acids; Free Radicals; GSK-3; Gastrocnemius muscle structure; Genetic; Gluconeogenesis; Glucose; Glycogen Synthase Kinase 3; Glycohemoglobin A; Glycosylated hemoglobin A; HDL; HPGF; Hb A1; Hb A1a+b; Hb A1c; HbA1; HbA1c; Heavy Lipoproteins; Hemoglobin A(1); Hepatocyte-Stimulating Factor; High Density Lipoproteins; High density lipoprotein; Histone H2B; Human; Human, Adult; Human, General; Humulin R; Hybridoma Growth Factor; Hyperinsulinemia; Hyperinsulinism; Hypertension; IFN-beta 2; IFNB2; IGF-1; IGF-I; IGF-I-SmC; IGF1; IL-6; IL6 Protein; Image; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intervention; Intervention Strategies; Intracellular Communication and Signaling; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; Leanness; Length of Life; Leptin; Life; Light; Lipids; Lipocytes; Lipoproteins, HDL; Liver; Longevity; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; MGI-2; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Mesenteric; Mesentery; Metabolic; Metabolic Pathway; Metabolic syndrome; Mice; Mitochondria; Mitochondria, Muscle; Modeling; Murine; Mus; Muscle Mitochondria; Muscle, Gastrocnemius; Myeloid Differentiation-Inducing Protein; Myokinase; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Novolin R; Nutrient; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; PRKM8; PRKM9; Pathology; Pathway interactions; Pattern; Phenotype; Phosphorylation; Photoradiation; Plasmacytoma Growth Factor; Population; Precipitation; Production; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Public Health; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Raptors; SAPK1; Sampling; Sarcosomes; Senescence; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Somatomedin C; Specific qualifier value; Specified; Staging; T2D; T2DM; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; TSC2; TSC2 gene; Testing; Thinness; Tissue Distribution; Tissues; Tomodensitometry; Tomography, Xray Computed; Triacylglycerol; Triglycerides; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Type 2 diabetes; Type II diabetes; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Visceral; Western Blotting; Western Blottings; Western Immunoblotting; Work; X-Ray Computed Tomography; adenylate kinase; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adipose; adiposity; adult human (21+); adult onset diabetes; advanced age; alpha-Lipoproteins; apM-1 protein; apM1 (adipose-specific) protein; biological signal transduction; body system, hepatic; catscan; computed axial tomography; computerized axial tomography; computerized tomography; corpulence; corpulency; corpulentia; diet restriction; dietary restriction; disease/disorder; elders; electron transfer; experiment; experimental research; experimental study; fasted; fasting glucose; fasts; feeding; follow-up; gene product; geriatric; glucose biosynthesis; glucose tolerance; glycogenolysis; gsk-3 Gene Product; hemoglobin A1c; human FRAP1 protein; human TNF protein; hyperpiesia; hyperpiesis; hypertensive disease; imaging; in vivo; inhibitor; inhibitor/antagonist; insulin resistant; insulin sensitivity; interferon beta 2; interventional strategy; ketosis resistant diabetes; late life; later life; life span; lifespan; mTOR; maturity onset diabetes; mitochondrial; mutant; ob/ob mouse; obese; obese people; obese person; obese population; older adult; older person; organ system, hepatic; oxidation; p54aSAPK; pathway; pediatric; programs; protein blotting; public health medicine (field); public health relevance; rapamycin and FKBP12 target 1 protein, human; research study; resistin; respiratory; restricted diet; senescent; senior citizen; subcutaneous; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; white adipose tissue; yellow adipose tissue",Lifespan Extension Despite Greatly Elevated Insulin and Body Fat," Relevance to Public Health In the US, the continuing increase in childhood and adult obesity is expected to increase such ailments as type 2 diabetes, hypertension, and metabolic syndrome as the population ages. This study will suggest treatments to retard deleterious changes with age, especially those related to high insulin levels and adiposity. Effects of DR that extend life spans in both normal control and ob/ob mice in this study are likely targets for interventions to retard aging and extend healthy lifespan in human beings.",32333,CMAD,Cellular Mechanisms in Aging and Development Study Section,A2,1,368385,
7781765,R01,AG,1,,02/01/2010,01/31/2011,PAR-08-062,1R01AG033673-01A1,,NIA:553397;,2010,NATIONAL INSTITUTE ON AGING,,KANSAS CITY,UNITED STATES,NEUROLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"BURNS, JEFFREY MURRAY;",7374732;,1R01AG033673,02/01/2010,01/31/2013,"Activities of Daily Living; Activities of everyday life; Adherence; Adherence (attribute); Aerobic; Aerobic Activity; Aerobic Exercise; Aged 65 and Over; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amentia; Animals; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior; Behavioral; Body Composition; Brain; Cachectin; Cachectin-Tumor Necrosis Factor; Care giver Burden; Caregiver Burden; Chemotherapy-Hormones/Steroids; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cities; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Cognition; Cognitive; Collaborations; Communities; Control Groups; Data; Dementia; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; Development; Differentiation Factor, B-Cell; Disease; Disease Progression; Disorder; Elderly; Elderly, over 65; Encephalon; Encephalons; Endocrine Gland Secretion; Exercise; Exercise, Physical; Fitness Centers; Funding; Generalized Growth; Growth; HPGF; Health; Health Policy; Hepatocyte-Stimulating Factor; History; Hormones; Human; Human, General; Humulin R; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IGF; IL-6; IL6 Protein; Individual; Inflammatory; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Like Growth Factors; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Investigation; Kansas; Life Style; Lifestyle; MGI-2; Man (Taxonomy); Man, Modern; Measures; Memory; Mental Depression; Methods; Myeloid Differentiation-Inducing Protein; Nervous System, Brain; Neuropsychologic Tests; Neuropsychological Tests; Novolin R; Outcome Measure; Performance; Physical activity; Physiologic; Physiological; Pilot Projects; Plasmacytoma Growth Factor; Population; Prevalence; Primary Senile Degenerative Dementia; Procedures; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Public Health; QOL; Quality of life; Randomized; Randomized Controlled Trials; Recording of previous events; Research; Role; Somatomedins; Staging; Stretching; Sulfation Factor; Symptoms; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Testing; Therapeutic Hormone; Tissue Growth; Training; Triacylglycerol; Triglycerides; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); advanced age; age dependent; age related; aging brain; animal data; base; behavior measurement; behavioral measure; behavioral measurement; biomarker; brain volume; care giver stress; caregiver stress; clinical investigation; community setting; comparison group; daily functioning; daily living functionality; dementia of the Alzheimer type; density; design; designing; disability; disease/disorder; elders; executive control; executive function; fitness; functional ability; functional capacity; gene product; geriatric; gray matter; health care policy; hippocampal atrophy; hippocampal atropy; human TNF protein; inflammatory marker; insulin sensitivity; insulinlike growth factor; interferon beta 2; late life; later life; meetings; morphometry; mouse model; neuroimaging; neuropathology; neuropsychiatric; neuropsychiatry; normal aging; older adult; older person; ontogeny; pilot study; pilot trial; prevent; preventing; primary degenerative dementia; primary outcome; programs; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; response; sarcopenia; secondary outcome; senile dementia of the Alzheimer type; senior citizen; social role; substantia grisea; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",Aerobic Fitness in Slowing the Progression of Alzheimer's Disease,"  Project Narrative: Strategies for promoting healthy brain aging and preventing Alzheimer's disease (AD) are increasingly important with the unprecedented growth of the elderly population and subsequent increase in the prevalence of AD. There is a need for rigorous, well-designed trials to more precisely define the role of exercise in AD. Demonstrating and defining the efficacy of exercise in AD would not only have an impact on public health policy in encouraging the public to adapt more active lifestyles, it would also stimulate the development of effective exercise delivery programs for individuals with AD.",33673,ZRG1,Special Emphasis Panel,A1,1,553397,
7785005,R01,AG,1,,02/01/2010,01/31/2011,PA-07-070,1R01AG033747-01A1,,NIA:334900;,2010,NATIONAL INSTITUTE ON AGING,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"ARTANDI, STEVEN E;",7814715;,1R01AG033747,02/01/2010,01/31/2015,"Address; Affinity; Affinity Chromatography; Age; Aged 65 and Over; Aging; Area; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemistry; Biogenesis; Biologic Assays; Biological Assay; Blotting, Northern; Body Tissues; Boxing; CHIP assay; Cell Culture Techniques; Cell Cycle; Cell Division Cycle; Cell Extracts; Cell Function; Cell Process; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Chemistry, Biological; Chromatography, Affinity; Chromosomes; Cole syndrome; Cole-Rauschkolb-Toomey syndrome; Complex; Coupled; Cultured Cells; DNA; Deoxyribonucleic Acid; Developed Countries; Developed Nations; Disease; Disorder; Dyskeratosis Congenita; Elderly; Elderly, over 65; Elements; Elongation by Telomerase; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Engman syndrome; Enzymes; Est2 protein; Fibroblasts; Gene Products, RNA; Genetic; Genetic Condition; Genetic Diseases; Genetics, Human; Hair Follicle; Hair follicle structure; Hereditary Disease; Holoenzymes; Human; Human Genetics; Human, General; Impairment; Individual; Industrialized Countries; Industrialized Nations; Knockout Mice; Length; Ligand Binding Protein; Malignant Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Modification; Molecular; Molecular Disease; Molecular Interaction; Morphogenesis; Mother Cells; Multienzyme Complexes; Murine; Mus; Mutate; Natural regeneration; Northern Blotting; Northern Blottings; Nuclear Structure; Nucleoproteins; Null Mouse; Origin of Life; Phenotype; Photometry/Spectrum Analysis, Mass; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Progenitor Cells; Proliferating; Proteins; Public Health; Quelling; RNA; RNA Interference; RNA Sequences; RNA Silencing; RNA Silencings; RNA blot analysis; RNA blotting; RNA, Non-Polyadenylated; RNAi; RNP; Recombinants; Regeneration; Regulation; Research; Ribonucleic Acid; Ribonucleoproteins; Role; Senescence; Sequence-Specific Posttranscriptional Gene Silencing; Sequences, RNA; Site; Skin; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stem cells; Stress; Structure; Subcellular Process; Syndrome; TERT protein; Telomerase; Telomerase RNA Component; Telomere Capping; Telomere Maintenance; Telomere Shortening; Therapeutic; Time; Tissues; United States; Zinsser syndrome; Zinsser-Engman-Cole syndrome; advanced age; affinity purification; age dependent; age related; aged; biological adaptation to stress; cancer cell; chromatin immunoprecipitation; congenital dyskeratosis; disease/disorder; dyskeratosis congenita (DC, DKC); elders; enzyme complex; ever shorter teleomeres protein 2; fitness; gene product; genetic disorder; geriatric; hereditary disorder; human tissue; improved; in vivo; intervention design; late life; later life; loss of function; mouse model; older adult; older person; particle; prevent; preventing; protein complex; public health medicine (field); public health relevance; reaction; crisis; regenerate; response; senescent; senior citizen; social role; stress response; stress; reaction; telomerase RNA; telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase catalytic subunit; telomere; therapy design; trafficking; treatment design",Defining the telomerase holoenzyme in progenitor cells with aging," Aging is a process during which fitness diminishes over time, resulting in impaired tissue function and reduced responses to stress. Aging, and the diseases to which aged individuals succumb, represent an enormous public health problem, particularly with the aging of the population in the United States and in other industrialized nations. The molecular changes that characterize and cause aging and aging-related disease are just being unraveled. One such change is the shortening of telomeres, the caps that protect the ends of our chromosomes. This proposal will study a new component of the enzyme telomerase that is required for maintaining telomeres. An improved understanding of telomerase is crucial for designing therapies that will delay or reverse certain aspects of aging.",33747,CMAD,Cellular Mechanisms in Aging and Development Study Section,A1,1,334900,
7761172,R01,AG,1,,02/01/2010,01/31/2011,PAR-09-016,1R01AG034901-01,,NIA:336883;,2010,NATIONAL INSTITUTE ON AGING,,WORCESTER,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"BOGDANOV, ALEXEI A;",6769611;,1R01AG034901,02/01/2010,01/31/2014,"Aneurysm; Apoplexy; Area; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Binding; Binding (Molecular Function); Biological Models; Blood Vessels; Blood monocyte; Body Tissues; Brain; Cardiac infarction; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Cell Surface Proteins; Cell surface; Cell-Extracellular Matrix; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Death; Developed Countries; Developed Nations; Developing Countries; Developing Nations; Diagnosis; Disease; Disease Progression; Disorder; ECM; Early treatment; Encephalon; Encephalons; Endothelial Cells; Enzymes; Erythrocuprein; Exocytosis; Experimental Models; Experimental Models, Other; Extracellular Matrix; Figs; Figs - dietary; H2O2; Heart; Hemocuprein; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; INFLM; Image; Imagery; In Vitro; Industrialized Countries; Industrialized Nations; Inflammation; Intracellular Communication and Signaling; Lesion; Less-Developed Countries; Less-Developed Nations; Life; Mammals, Rabbits; Marrow monocyte; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Model System; Modeling; Models, Biologic; Models, Experimental; Molecular Interaction; Molecular Probes; Monitor; Mortality; Mortality Vital Statistics; Myocardial Infarct; Myocardial Infarction; NADPH Oxidase; Nervous System, Brain; Nuclear; Oryctolagus cuniculus; Pathology; Pathway interactions; Patients; Peroxidases; Population; Production; Property; Property, LOINC Axis 2; Proteins, Cell Surface; Rabbit, Domestic; Rabbits; Radioactive Isotopes; Radioisotopes; Radionuclides; Reporter; Reporting; Research; Rupture; SOD; Science of Statistics; Signal Transduction; Signal Transduction Systems; Signaling; Site; Statistics; Streaks, Arterial Fatty; Stroke; Superoxide Anion; Superoxide Dismutase; Superoxide Radical; Superoxide[{..}]superoxide oxidoreductase; Superoxides; Testing; Third-World Countries; Third-World Nations; Tissues; Toxic effect; Toxicities; Toxicity Testing; Toxicity Tests; Translations; Under-Developed Countries; Under-Developed Nations; Vascular Accident, Brain; Vascular blood supply; Visualization; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; base; biological signal transduction; blood supply; brain attack; cardiac infarct; cardiovascular disorder; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; cost; cytocuprein; design; designing; disease/disorder; heart attack; heart infarct; heart infarction; imaging; imaging probe; in vitro testing; in vivo; inflammatory marker; molecular imaging; monocyte; novel; pathway; prevent; preventing; public health relevance; response; sensor; statistics; stroke; tumor; vascular; vascular inflammation; vascular supply; vulnerable plaque",Molecular Imaging Probes for Reporting on Vascular Oxidative Response," Diseased blood vessel walls frequently develop lesions that can become unstable and rupture. The rupture leads to blocking blood supply and death of tissues in the brain and heart and may result in debilitating disease and loss of life. We propose to develop agents that can report on areas of instability in blood vessels and detoxify some of the reactive molecules that cause instability, which has implications in preventing heart attacks and strokes by identifying patients who carry unstable lesions and who can benefit from early treatment of such unstable leasions.",34901,ZRG1,Special Emphasis Panel,,1,336883,
7767031,R01,AG,1,,02/01/2010,01/31/2011,PA-07-070,1R01AG034972-01,,NIA:333125;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"WALSH, KENNETH ;",1880570;,1R01AG034972,02/01/2010,01/31/2015,"Activin-Binding Protein; Acute; Age; Aged 65 and Over; Aging; Animals; Atrophy, Muscle; Biochemical; Body Tissues; Bypass; Cell Communication and Signaling; Cell Signaling; Cells; Communication; Dysfunction; Elderly; Elderly, over 65; FSTL1 Gene Product; Fiber; Follistatin; Follistatin Like Protein 1; Follistatin-Related Protein 1; Functional disorder; Generalized Growth; Genetic; Grant; Growth; In Vitro; Injury; Intermediary Metabolism; Intracellular Communication and Signaling; Knockout Mice; METBL; Mammals, Mice; Mediating; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Murine; Mus; Muscle; Muscle Tissue; Muscle function; Muscular Atrophy; Natural regeneration; Null Mouse; Organism; Phenotype; Physiologic; Physiological; Physiopathology; Prevalence; Production; Proteins; Recombinants; Regeneration; Regulation; Role; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Testing; Tissue Growth; Tissues; Vascular Endothelial Cell; advanced age; age dependent; age related; base; biological signal transduction; cost; design; designing; drug discovery; elders; experiment; experimental research; experimental study; gene product; geriatric; in vivo; late life; later life; living system; loss of function; mid life; mid-life; middle age; middle aged; midlife; muscle aging; muscle form; new therapeutics; next generation therapeutics; novel therapeutics; older adult; older person; ontogeny; paracrine; pathophysiology; progenitor; public health relevance; regenerate; research study; response; sarcopenia; senescent; senior citizen; skeletal muscle growth; social role; socioeconomic; socioeconomically; socioeconomics; treatment strategy; wasting",Muscle loss and metabolic dysfunction associated with aging," PROJECT NARRATIVE Despite the prevalence and socioeconomic costs associated with conditions of muscle wasting, few treatment strategies for muscle atrophy have been identified. The Akt signaling pathway profoundly influences muscle growth, degradation and survival. Whereas previous studies have shown that reductions in Akt-associated signaling correlate with muscle age and type IIb fiber loss, the proposed studies will provide causal evidence that modulation of this signaling step will impact the phenotype of aging muscle.",34972,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,1,333125,
7766528,R01,AG,1,,02/01/2010,01/31/2011,PA-07-070,1R01AG034994-01,,NIA:316088;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"FONTANA, WALTER ;",6715110;,1R01AG034994,02/01/2010,01/31/2015,"ATP-protein phosphotransferase; Affect; Age; Aging; Aging Process; Aging, Demographic; Aging-Related Process; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Analysis, Data; Animals; Assay; Attention; Bioassay; Biologic Assays; Biological Assay; C elegans; C.elegans; Caenorhabditis elegans; Categories; Cessation of life; Code; Coding System; Collection; Communities; Computer Programs; Computer software; Cues; Culture Procedure; DNA Alteration; DNA mutation; Data; Data Analyses; Death; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Demographer; Demographic Aging; Descriptor; Development; Dimensions; Disease; Disorder; Electronics; Environment; Future; Gene Alteration; Gene Family; Gene Mutation; Gene Transfer Clinical; Gene Transfer Procedure; Gene variant; Gene-Tx; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Intervention; Genetic Variation; Genetic defect; Genetic mutation; Genome; Genotype; Human; Human, General; INSR; Idiopathic Parkinson Disease; Image; Image Analyses; Image Analysis; Imagery; Individual; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin-Dependent Tyrosine Protein Kinase; Intervention, Genetic; Knowledge; Laboratory culture; Length of Life; Lewy Body Parkinson Disease; Link; Longevity; Man (Taxonomy); Man, Modern; Manuals; Maps; Measures; Methods; Modeling; Molecular; Molecular Biology, Gene Therapy; Mortality; Mortality Vital Statistics; Movement; Mutation; Nature; Nematoda; Nematodes; Organism; Paralysis Agitans; Parental Ages; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pattern; Phenotype; Population; Population Characteristics; Primary Parkinsonism; Primary Senile Degenerative Dementia; Procedures; Process; Protein Kinase; Protocol; Protocols documentation; ROC Analysis; Reporting; Research; Research Resources; Resolution; Resources; Risk; Running; SCHED; Sampling; Schedule; Senescence; Sequence Alteration; Series; Shapes; Side; Software; Structure; Survey Instrument; Surveys; Technology; Temperature; Testing; Therapy, DNA; Time; Variant; Variation; Variation (Genetics); Visualization; Work; age dependent; age effect; age related; aging effect; allelic variant; base; body movement; cancer type; computer program/software; data acquisition; dementia of the Alzheimer type; disease/disorder; dosage; gene function; gene therapy; genetic therapy; genome mutation; glycogen synthase a kinase; hazard; hydroxyalkyl protein kinase; image evaluation; imaging; insight; life span; lifespan; living system; mutant; pathway; phosphorylase b kinase kinase; primary degenerative dementia; public health relevance; reproductive; roundworm; senescent; senile dementia of the Alzheimer type; transcription factor",The variability of the lifespan phenotype in C.elegans," Animals ranging from worms to humans become frail, disease prone, and more likely to die as they age. We will use an automated method for measuring death times of C. elegans nematodes to probe why some individuals die sooner than others. By observing the effect of 2,000 separate gene mutations on aging worm populations, this project will provide insight about how genes work together to affect the aging process.",34994,CMAD,Cellular Mechanisms in Aging and Development Study Section,,1,316088,
7890673,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI076899-01A1,,NIAID:355551;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SANTA BARBARA,UNITED STATES,CHEMISTRY,23,094878394,US,CA,93106,UNIVERSITY OF CALIFORNIA SANTA BARBARA,"PLAXCO, KEVIN W.;",1898497;,1R01AI076899,02/01/2010,01/31/2015,"Acute; Address; Affect; Affinity; Architecture; Binding; Binding (Molecular Function); Biomedical Engineering; Biosensor; Blood; Blood Sample; Blood Serum; Blood specimen; Buffers; Care, Health; Cell Communication and Signaling; Cell Signaling; Chemistry; Clinical; Complex; Cytokines, Chemotactic; DNA Binding; DNA Binding Interaction; Data; Dependence; Detection; Development; Device or Instrument Development; Devices; Diagnostic; Discipline; Doctor of Medicine; Electrodes; Electronics; Elements; Engineering / Architecture; Environmental Factor; Environmental Risk Factor; Equilibrium; Event; Exhibits; Figs; Figs - dietary; Fingers; Generations; Goals; Graft Rejection; Grafting, Kidney; Hand; Health Care Costs; Health Costs; Healthcare; Healthcare Costs; Homologous Chemotactic Cytokines; Hour; Intercrines; Intracellular Communication and Signaling; Ionic Strengths; Kidney Transplantation; Kidney Transplants; Laboratories; Laboratory Procedures; M.D.; Measurement; Measures; Methods; Microfluidic; Microfluidics; Molecular; Molecular Interaction; Output; Oxidation-Reduction; PROV; Patients; Property; Property, LOINC Axis 2; Proteins; Provider; Reagent; Redox; Renal Transplantation; Renal Transplants; Reporting; Reproducibility; Research Resources; Resources; Reticuloendothelial System, Blood; Route; SIS cytokines; Saline; Saline Solution; Sampling; Science of Chemistry; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Strengths, Ionic; Structure; Surface; Survey Instrument; Surveys; Technology; Temperature; Testing; Time; Translating; Translatings; Transplant Rejection; Transplantation Rejection; Urinary System, Urine; Urine; WHBLOOD; Whole Blood; allograft rejection; aptamer; balance; balance function; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; biomarker; chemoattractant cytokine; chemokine; clinical applicability; clinical application; clinical material; clinical practice; clinical relevance; clinically relevant; cost; cost effectiveness; density; device development; directed evolution; environmental risk; gene product; improved; innovate; innovation; innovative; instrument development; kidney allograft; language translation; molecular marker; novel; oxidation reduction reaction; point of care; point-of-care diagnostics; public health relevance; rapid detection; renal allograft; response; sensor; sensor (biological); success; urinary",Rapid detection of diagnostic chemokines," Relevance Current methods for the detection of diagnostic proteins require cumbersome, resource-intensive laboratory procedures that typically require hours or days to provide clinicians with therapeutically actionable diagnostic information. Here we propose the development of a new class of electronic (electrochemical) biosensors aimed at the rapid (<15 minutes), point-of-care quantification of multiple protein biomarkers directly in unprocessed clinical samples (i.e., urine and finger-lance samples of blood). The successful implementation of such a technology would significantly shorten the time between examination and treatment, which, in turn, will improve healthcare efficacy and transform the healthcare cost structure. While our long-term objective is the development of devices suitable for the detection of any of a wide range of diagnostic proteins, our initial efforts will focus on a representative and particularly pressing application for which comparison with standard clinical approaches is readily achieved: the measurement of urinary and blood-borne chemokines diagnostic of kidney transplant rejection. 5",76899,ZRG1,Special Emphasis Panel,A1,1,355551,
7792074,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI078183-01A2,,NIAID:689552;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DAVIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"LANZARO, GREGORY C.;LUCKHART, SHIRLEY  (contact);",1875431;1976026 (contact);,1R01AI078183,01/15/2010,12/31/2014,"Address; Affect; Africa South of the Sahara; Africa, Central; Alleles; Allelomorphs; Anopheles gambiae; Cameroon; Cameroons; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Central Africa; Chemicals; Chromosome inversion; Code; Coding System; Codon; Codon Nucleotides; Country; Culicidae; Data; Development; Exhibits; Gene Conversion; Gene Targeting; Gene Transfer Techniques; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetic analyses; Genetics, Population; Genotype; Geographic Distribution; Goals; Human; Human, General; Humulin R; Immune; Immune response; Immune system; Immunity; In Vitro; Infection; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Inversion, Chromosomal; Inversion, Sequence; Karyotype; Knowledge; Laboratory Study; Light; Malaria; Mali; Man (Taxonomy); Man, Modern; Maps; Mediating; Methods; Methods and Techniques; Methods, Other; Midgut; Molecular; Mosquitoes; Nature; Novolin R; O'nyong-nyong virus; Paludism; Parasites; Phenotype; Photoradiation; Plasmodium Infections; Plasmodium falciparum; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Population Genetics; Predisposition; Protocol; Protocols documentation; Regulation; SNP; SNPs; Sampling; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Site; Sub-Saharan Africa; Subsaharan Africa; Susceptibility; Targetings, Gene; Techniques; Testing; Transfection; Transgenesis; Translations; Transmission; United Republic of Cameroon; Variation (Genetics); Work; allelic variant; base; biological signal transduction; body system, allergic/immunologic; cultured cell line; forest; gene function; genetic analysis; host response; immunoresponse; in vivo; inhibitor; inhibitor/antagonist; insight; interest; karyogram; knock-down; novel; organ system, allergic/immunologic; overexpression; polymorphism; protein function; protein structure; public health relevance; reproductive; response; screening; screenings; transmission process; vector",An.gambiae immune signaling gene SNPs and natural P. falciparum infection," Narrative The mosquito Anopheles gambiae transmits the human malaria parasite Plasmodium falciparum in sub-Saharan Africa. Many laboratory studies have focused on how the mosquito immune system responds to and destroys these parasites, but there is little to no information on whether these responses are important in nature. Our studies will identify responses that are important in natural populations of An. gambiae with the long-term goal that this information can contribute to novel malaria control methods.",78183,ZRG1,Special Emphasis Panel,A2,1,689552,
7887391,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI079178-01A2,,NIAID:437604;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,622146454,US,NY,100214872,HOSPITAL FOR SPECIAL SURGERY,"LU, THERESA ;",8192362;,1R01AI079178,02/01/2010,01/31/2015,"Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Attenuated; Autoimmune; Autoimmune Process; Autoimmune Responses; B blood cells; B-Cells; B-Lymphocytes; Bevacizumab (rhuMAb VEGF); Blood; Blood Vessels; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD106; CD106 Antigens; CD11c; Cell Communication; Cell Function; Cell Growth in Number; Cell Interaction; Cell Multiplication; Cell Process; Cell Proliferation; Cell Survival; Cell Viability; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; DIF; Data; Dendritic Cells; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Dysfunction; Endothelial Cells; Ensure; Family; Fibroblasts; Functional disorder; Gene Deletion; Generalized Growth; Goals; Growth; High Endothelial Venule; Humoral Immunities; INCAM-110; ITGAX; ITGAX gene; Immune; Immune Function, Cellular; Immune response; Immune system; Immunities, Humoral; Immunity; In Vitro; Inducible Cell Adhesion Molecule 110; Lupus; Lymph node proper; Lymphatic Tissue; Lymphoid Tissue; Lymphoproliferative Disorders; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Methods and Techniques; Methods, Other; Mice; Micronutrients; MoAb VEGF; Molecular; Monoclonal Antibody Anti-VEGF; Murine; Mus; O element; O2 element; Oxygen; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phenotype; Physiopathology; Play; Population; Process; Proliferating; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Regulation; Reporter; Research; Resolution; Reticular Cell; Reticuloendothelial System, Blood; Reticuloendothelial System, Lymph Node; RhuMAb VEGF; Role; Stromal Cells; Subcellular Process; T-Cell Development; T-Cell Ontogeny; T-Lymphocyte Development; TNF; TNF A; TNF gene; TNFSF2; Techniques; Testing; Tissue Growth; Tumor Necrosis Factor Gene; VCAM; VCAM-1; VEGFs; Vaccines; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factors; Vegf; Veiled Cells; Work; antibody-based immunity; attenuation; bevacizumab; body system, allergic/immunologic; disease/disorder; drug/agent; feeding; gene deletion mutation; host response; immune function; immunoresponse; in vivo; insight; lymph gland; lymph nodes; lymphoproliferative disease; novel; ontogeny; organ system, allergic/immunologic; pathophysiology; public health relevance; response; rhuMabVEGF; social role; trafficking; vascular",Vascular Quiescence and Stabilization in Immunity, Blood vessels feed the lymph node and are likely to be important in controlling the normal development of an immune response. This research investigates how newly expanded blood vessels in the lymph node blood become stabilized and functional. This research has implications for development of new strategies to downregulate detrimental autoimmune responses in diseases such as lupus and to upregulate responses to vaccines.,79178,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,A2,1,437604,
7890106,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI080658-01A2,,NIAID:305000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"SMITH, GREGORY ALLAN;",1933714;,1R01AI080658,02/01/2010,01/31/2015,"0-6 weeks old; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Aclovir; Acycloguanosine; Acyclovir; Address; Affect; Antiviral Agents; Antiviral Drugs; Antivirals; Aujeszky's Disease Virus; Aujeszkys Disease Virus; Blindness; Capsid; Capsid Proteins; Cargosil; Cell Nucleus; Cells; Chickenpox Virus; Coat Proteins; Comparative Study; Country; Coupled; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasm; Developed Countries; Developed Nations; Disease; Disease Progression; Disorder; Encephalitis; Genetics-Mutagenesis; Glaxo Wellcome Brand of Aciclovir; Glaxo Wellcome Brand of Aciclovir Sodium Salt; Goals; HHV-1; HHV-2; HHV-3; HSV; HSV-1; HSV-2; HSV1; HSV2; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus 2; Herpes Simplex Virus Type 1; Herpes Simplex Virus Type 2; Herpes Zoster; Herpes labialis Virus; Herpes zoster Virus; Herpes zoster disease; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1 (alpha), Suid; Herpesvirus 1, Human; Herpesvirus 1, Suid; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus 3 (alpha), Human; Herpesvirus Suis; Herpesvirus hominis; Herpesvirus progenitalis; Herpesvirus varicellae; Herpesviruses; Heterogeneity; Human; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human herpes simplex virus type 1; Human herpes simplex virus type 2; Human herpesvirus 1; Human herpesvirus 3; Human herpesvirus type 1; Human, General; Individual; Industrialized Countries; Industrialized Nations; Infant, Newborn; Infection; Inflammation, Brain; Intervention; Intervention Strategies; Keratitis; Life; Link; Man (Taxonomy); Man, Modern; Measures; Molecular; Molecular Biology, Mutagenesis; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutagenesis; Neonatal; Newborn Infant; Newborns; Nuclear; Nuclear Envelope; Nuclear Membrane; Nucleus; Ocular Herpes zoster Virus; Parke Davis Brand of Aciclovir; Pathway interactions; Poviral; Process; Property; Property, LOINC Axis 2; Proteins; Pseudorabies virus; Role; SUBGP; Series; Shingles; Simplexvirus; Single Crystal Diffraction; Staging; Structure; Study models; Subgroup; Suid Herpesvirus 1; Swine Herpesvirus 1; VIVIPAROUS1 protein; VZ Virus; Varicella-Zoster Virus; Varicellovirus; Viral; Viral Coat Proteins; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Outer Coat Protein; Viral Pathogenesis; Viral Proteins; Virorax; Virus; Virus Diseases; Viruses, General; Viviparous-1 protein; Vp1 protein; Warner Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir Sodium Salt; X Ray Crystallographies; X-Ray Crystallography; Zona; Zoster; Zovirax; Zovirax for Injection; base; coat (nonenveloped virus); disease/disorder; domain mapping; fluorescence imaging; gene product; herpes simplex i; herpes simplex ii; herpes virus; herpes virus 1, human; herpes zona; herpesvirus; human alphaherpesvirus 1; human alphaherpesvirus 2; human alphaherpesvirus 3; human herpesvirus 1 group; human herpesvirus 3 group; imaging modality; interventional strategy; member; mutant; new approaches; newborn human (0-6 weeks); novel approaches; novel strategies; novel strategy; particle; pathogen; pathway; public health relevance; social role; viral infection; virus infection; virus protein",Alpha-herpevirus assembly egress and viral particle heterogeneity," Neuroinvasive herpesviruses are the causative agents of a number of severe diseases including shingles, encephalitis, neonatal infections and herpes keratitis (the leading cause of infectious blindness in the USA and other industrialized nations). This proposal focuses on understanding the molecular mechanisms that underlie the assembly and egress of herpesvirus particles, with the long- term goal of identifying new targets for the intervention of disease progression.",80658,VIRB,Virology - B Study Section,A2,1,305000,
7887997,R01,AI,1,,04/01/2010,03/31/2011,PA-07-070,1R01AI080688-01A2,,NIAID:372205;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RICHMOND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"ROSATO, ADRIANA E;",7269926;,1R01AI080688,04/01/2010,03/31/2015,"2,6 dimethoxyphenylpenicillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; American; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibiotics, Monobactam; Appearance; Bacteria; Binding; Binding (Molecular Function); Biology; CDC; Care, Health; Cell Function; Cell Process; Cell Wall; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Clinical; Communities; Data; Death; Detection; Development; Environment; Enzymes; Exposure to; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genus staphylococcus; Goals; HOSP; Healthcare; Heterogeneity; Hospital Infections; Hospital acquired infection; Hospitals; Hydrolysis; Immunologic Deficiency Syndrome, Acquired; Incidence; Infection; Infection Control; Killings; Knowledge; Laboratories; Lactam Antibiotics; Lactamase; Lactams; Life; Link; MRSA; Mediating; Methicillin; Methicillin Resistance; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Minor; Miscellaneous Antibiotic; Modeling; Molecular Interaction; Monobactams; Monocyclic beta-Lactams; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutation; Nosocomial Infections; Out-patients; Outpatients; Oxacillin; Oxazocilline; Pathway interactions; Patients; Penicillin, Dimethoxyphenyl; Penicillin, Methylphenylisoxazolyl; Penicillin-Binding Proteins; Phenotype; Pneumonia; Pneumonitis; Population; Process; Programs (PT); Programs [Publication Type]; Pulmonary Inflammation; Research; Research Resources; Resistance; Resources; Risk Factors; Role; S. aureus; S.aureus; SOS Function; SOS Induction; SOS Repair; SOS Response; SOS Response (Genetics); SOS System; Skin; Soft Tissue Infections; Staphylococcus; Staphylococcus aureus; Subcellular Process; Syndrome; Toxic Shock; Toxic Shock Syndrome; Tuberculosis; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral hepatitis; Virulent; anti-microbial; antimicrobial; bactericidal; bactericide; beta lactam antibiotic; chemotherapy; clinical relevance; clinically relevant; cross-link; crosslink; disseminated TB; disseminated tuberculosis; genome mutation; insight; institutional infection; methicillin resistant; methicillin resistant Staphylococcus aureus (organism); novel; pathogen; pathway; programs; public health relevance; resistant; social role; soft tissue; tuberculous spondyloarthropathy",B-lactam mediated SOS response and expression of resistance in clinical MRSA," SIGNIFICANCE OF THE PROPOSED RESEARCH. Clinical Methicillin-Resistant S.aureus (MRSA) isolates expressing low levels of resistance and being misinterpreted as oxacillin-susceptible are a growing concern. These strains spread unnoticed in the hospital environment in both patients and staff. Oxacillin susceptible low level mecA mediated resistance MRSA strains are very heterogeneous (HeR) in expression and clinically relevant since exposure of such isolates to ¨-lactams can result in high-level resistance. The central hypothesis of this proposal is that upon exposure to ¨-lactams, MRSA (SA13011) is selected from a heterotypic (HeR) to a homotypic resistant phenotype (HoR) by a ¨-lactam-induced SOS response that leads to an agr-genetically controlled increased mutation rate that helps to maintain, among others, the cell wall integrity.",80688,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,A2,1,372205,
7884039,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI081690-01A2,,NIAID:375993;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,ZOOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MUNDERLOH, ULRIKE GERTRUD;",2108383;,1R01AI081690,01/15/2010,12/31/2014,"Antibiotic Resistance; Aphaniptera; Arthropoda; Arthropods; Bacteria; Biologic Sciences; Biological Sciences; Biology; Blood; Blotting, Southern; Cells; Characteristics; DNA blotting; Disease; Disorder; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Pulsed-Field Gradient; Fever; Fleas; Fractionation, Pulse Field; Gene Transfer, Horizontal; Gene Transfer, Lateral; Gene variant; Generalized Growth; Genetic; Genetic Diversity; Genetic Variation; Genome; Gram-Negative Bacteria; Growth; History; Horizontal Gene Transfer; Human; Human, General; Hyperthermia; Insecta; Insects; Invertebrates, Insects; Ixodida; Laboratories; Lice; Life Sciences; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Metabolic; Methods and Techniques; Methods, Other; Mites; Mitochondria; PFGE; Phenotype; Phthiraptera; Phylogenetic Analysis; Phylogenetics; Phylogeny; Plasmids; Pyrexia; Recording of previous events; Relative; Relative (related person); Research; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Blood; Rickettsia; Rickettsia Infections; Rickettsial Infectious Disease; Rickettsial Infectious Disorder; Rickettsiales disease; Rickettsiosis; Role; SEQ-AN; Sequence Analyses; Sequence Analysis; Siphonaptera; Source; Southern Blotting; Spottings; Techniques; Technology; Testing; Ticks; Tissue Growth; Transmission; Typhus; Variation (Genetics); Virulence; allelic variant; antibiotic resistant; comparative; disease/disorder; experiment; experimental research; experimental study; febrile; febris; feeding; genetic element; genetic manipulation; member; microbial; mitochondrial; ontogeny; pathogen; pathogenic bacteria; public health relevance; research study; resistant; rickettsial disease; social role; tool; transmission process; vector",The Role of Plasmids in Rickettsia Biology," Project Narrative Obligate intracellular bacteria of the genus Rickettsia are transmitted by blood-feeding insects and ticks. Members of the Rickettsia cause disease in humans that includes typhus and spotted fevers. The proposed research will characterize newly discovered genetic components (plasmids) of the Rickettsia and how they may contribute to the ability of these bacteria to infect insects, ticks and humans. The results of this research may provide new tools to control Rickettsia infections of humans.",81690,BACP,Bacterial Pathogenesis Study Section,A2,1,375993,
7781065,R01,AI,1,,01/01/2010,12/31/2010,PA-07-070,1R01AI081724-01A1,,NIAID:442500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"GOLDBERG, MARCIA B;",1898301;,1R01AI081724,01/01/2010,12/31/2014,"Actins; Adhesion Plaques; Bacteria; Binding; Binding (Molecular Function); Biochemical; Biological; Body Tissues; C-terminal; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cell surface; Cell-Matrix Adherens Junctions; Cells; Cellular Migration; Cellular Stress; Cytolysis; Cytoplasmic Membrane; Data; Development; Diarrhea; Disease; Disorder; Dysentery; Effector Cell; Event; Focal Adhesions; Focal Contacts; GWAS; Genes; Genome, Human; Host Factor; Host Factor Protein; Human; Human Cell Line; Human Genome; Human, General; Infection; Infectious Diarrheal Disease; Integration Host Factors; Interphase Cell; Intestinal; Intestines; Intracellular Communication and Signaling; Invaded; Investigation; Knowledge; Lead; Lysis; Man (Taxonomy); Man, Modern; Microorganisms, General; Modeling; Molecular; Molecular Interaction; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Movement; Mucosa; Mucosal Tissue; Mucous Membrane; N-terminal; NH2-terminal; Non-dividing Cell; ORFs; Open Reading Frames; Organism; Pathogenesis; Pathway interactions; Pb element; Plasma Membrane; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Coding Region; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Resting Cell; Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation; Role; S. flexneri; S. sonnei; Sequence-Specific Posttranscriptional Gene Silencing; Shigella; Shigella flexneri; Shigella flexneri bacterium; Shigella sonnei; Shigella sonnei bacterium; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Stress Fiber Formation Pathway; Stress Fibers; Tail; Testing; Therapeutic; Tissues; Vacuole; base; biological signal transduction; body movement; bowel; cell motility; design; designing; disease/disorder; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; human tissue; improved; insight; living system; microorganism; monolayer; pathogen; pathway; plasmalemma; public health relevance; response; siRNA; social role; whole genome association studies; whole genome association study",Molecular signaling in Shigella dissemination, The human pathogen Shigella is a bacterium that causes diarrhea by infecting cells that line the human intestinal tract and disseminating through intestinal tissue by mechanisms that are poorly understood. The bacterium promotes dissemination by producing molecules that trigger specific responses in the infected cells that enhance the movement of bacteria into adjacent uninfected cells; we propose detailed studies into the molecular signaling involved in the dissemination of Shigella through tissue. Our results could lead to an improved understanding of how pathogens interact with human tissue and the development of better therapeutics.,81724,HIBP,Host Interactions with Bacterial Pathogens Study Section,A1,1,442500,
7885216,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI081830-01A1,,NIAID:292150;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,OMAHA,UNITED STATES,PATHOLOGY,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"CHAPMAN, NORA M.;",8376548;,1R01AI081830,01/15/2010,12/31/2012,"0-11 years old; 21+ years old; Acute; Adult; Affect; Binding; Binding (Molecular Function); Binding Sites; Biology; Body Tissues; C 1 Esterase; C1 Esterase; C1 s; C1s; Cardiomyopathy, Dilated; Causality; Cell Culture Techniques; Cell Nucleus; Cells; Child; Child Youth; Children (0-21); Chronic; Chronic Disease; Chronic Illness; Combining Site; Complement 1 Esterase; Complement 1s; Complement component C1s; Complex; Congestive Cardiomyopathy; Coxsackie B Viruses; Coxsackieviruses B; Culturing, in vitro Vertebrate, Primary; Cytoplasm; Dilated Cardiomyopathy; Disease; Disorder; Effects, Longterm; Enterovirus; Enterovirus Infections; Environment; Etiology; Event; Face; Family Picornaviridae; Gene Products, RNA; Generalized Growth; Generations; Genome; Genomics; Goals; Growth; Heart; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Human; Human poliovirus; Human, Adult; Human, Child; Human, General; Immune; Immune response; Infection; Knowledge; Laboratories; Lead; Life Style; Lifestyle; Link; Long-Term Effects; Lytic; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Molecular Interaction; Murine; Mus; Mutate; Myocarditis; Neurologic; Neurological; Nuclear; Nucleotides; Nucleus; Pancreatic Diseases; Pancreatic Disorder; Pb element; Picornaviridae; Picornaviruses; Polio Virus; Poliovirus; Polioviruses; Population; Primary Cell Cultures; Process; Production; Proteins; RNA; RNA Viruses; RNA chemical synthesis; RNA replication; RNA synthesis; RNA, Non-Polyadenylated; RNA, Viral; Reactive Site; Reporting; Ribonucleic Acid; Role; Serotyping; Site; Sound; Sound - physical agent; Time; Tissue Growth; Tissues; Variant; Variation; Viral; Viral Activity; Viral Function; Viral Physiology; Virion; Virus; Virus Particle; Viruses, General; Work; adult human (21+); base; children; chronic disease/disorder; chronic disorder; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; facial; fascinate; gene product; heart function; heavy metal Pb; heavy metal lead; host response; human disease; immunoresponse; insight; novel; ontogeny; pancreas disorder; poliomyelitis virus; protein structure; public health relevance; social role; sound; viral RNA; viral detection; virus RNA; virus detection; youngster",5' End Genomic Deletions and Enterovirus Persistence," Project Narrative: This study is to determine the conditions and processes for generation of persistent enterovirus infections. These infections in hearts are associated with long term effects upon heart function including debiliating conditions such as dilated cardiomyopathy and chronic myocarditis. Understanding how selection of these variant viruses occurs and how these viruses replicate will provide the basis for developing treatments and detection of these viruses in heart, neurological and pancreatic disease.",81830,VIRB,Virology - B Study Section,A1,1,292150,
7897509,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI081861-01A2,,NIAID:333000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MEMPHIS,UNITED STATES,OTHER BASIC SCIENCES,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"RE, FABIO C;",6194824;,1R01AI081861,01/15/2010,12/31/2014,"1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-; 2,6,8-Trihydroxypurine; Active Oxygen; Address; Adjuvant; Adjuvanticity; Alum Adjuvant; Amphoterin; Amphoterin Gene; Applications Grants; Biological; Box Protein 1, High Mobility Group; Cell Communication and Signaling; Cell Signaling; Cells; Chitosan; Chromosomal Protein, Nonhistone, HMG1; Chromosomal Protein, Nonhistone, HMG1 Gene; Communicable Diseases; Cytoplasm; Developing Countries; Developing Nations; Drug Formulations; Edodekin Alfa; FM1 Gene Product; Family; Formulation; Formulations, Drug; Generations; Goals; Grant Proposals; Grants, Applications; HMG-1; HMG-1 Gene; HMG-1 Protein; HMG1; HMG1 Gene; HMG3; HMG3 Gene; HMGB1; HMGB1 Protein; HMGB1 gene; Heparin-Binding Protein p30; High Mobility Group Protein 1; High Mobility Group Protein 1 Gene; High-Mobility Group (Nonhistone Chromosomal) Protein 1; High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene; High-Mobility Group Box 1; High-Mobility Group Box 1 Gene; Human; Human, General; IFN-gamma-Inducing Factor; IGIF; IL-1; IL-1 Gamma; IL-12; IL-18; IL-1g; IL1; IL12; IL18 Protein; IL1F4; Immune response; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin I; Interleukin-1; Interleukin-1 Gamma; Interleukin-12; Interleukin-18; Interleukin-18 Precursor; Intracellular Communication and Signaling; Knockout Mice; Less-Developed Countries; Less-Developed Nations; Lymphocyte-Stimulating Hormone; MF59; MGC12320; Macromolecular Protein Complexes; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Multiprotein Complexes; Murine; Mus; Myelogenous; Myeloid; NKSF; Natural Killer Cell Stimulatory Factor; Necrosis; Necrotic; Nonhistone Chromosomal Protein HGM1; Nonhistone Chromosomal Protein HGM1 Gene; Null Mouse; Oxidative Stress; Oxygen Radicals; Particulate; Pathway interactions; Pattern recognition receptor; Peritoneal; Poliglusam; Pro-Oxidants; Property; Property, LOINC Axis 2; Publishing; Radio; Reactive Oxygen Species; Receptor Protein; Recombinants; Residual; Residual state; Resistance; Role; SBP-1; SBP-1 Gene; SYK protein, human; Signal Transduction; Signal Transduction Systems; Signaling; Source; Spleen Tyrosine Kinase; Sulfoglucuronyl Carbohydrate Binding Protein; Sulfoglucuronyl Carbohydrate Binding Protein Gene; Syk kinase; T Helper Factor; Testing; Third-World Countries; Third-World Nations; Trioxopurine; Tyrosine-Protein Kinase SYK; Under-Developed Countries; Under-Developed Nations; Uric Acid; Vaccination; Vaccines; alum; aluminum sulfate; base; biological signal transduction; cell type; cytokine; design; designing; fighting; host response; human SYK protein; immunoresponse; improved; in vivo; indigo red; indirubin; lymphocyte activating factor; microbial; p72(syk); p72syk; pathway; public health relevance; receptor; resistant; response; social role; spleen tyrosine kinase, human",Role of NLRP3-inflammasome in alum's adjuvanticity," Alum is the only adjuvant approved for routine use in human vaccination although the basis for its immunostimulatory activity remains poorly understood. The studies described in this grant proposal will increase our understanding of the mechanism of action of alum. A deeper understanding of the mechanisms that determine the immunostimulatory properties of adjuvants is a prerequisite for the rational design of more sophisticated vaccines, which remain the most promising strategy to fight infectious diseases in both industrialized and developing countries.",81861,VMD,Vaccines Against Microbial Diseases Study Section,A2,1,333000,
7917958,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI081878-01A1,,NIAID:390000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DENVER,UNITED STATES,,01,076443019,US,CO,80206,NATIONAL JEWISH HEALTH,"HAGMAN, JAMES R;",1932929;,1R01AI081878,02/01/2010,01/31/2015,"Address; Alleles; Allelomorphs; Antibodies; Autoimmune Diseases; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD19; CD19 gene; Cancers; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cells; Cytotoxic cell; DNA Rearrangement; DNA Sequence Rearrangement; Defect; Development; Exhibits; Gene Expression; Gene Rearrangement; Gene Targeting; Gene Transcription; Genes; Genes, Ig; Genes, Immunoglobulin; Genetic Transcription; Hematopoietic; Immune Globulins; Immunoglobulin Genes; Immunoglobulin V(D)J Rearrangement; Immunoglobulins; Immunoglobulins / Antibodies; Intracellular Communication and Signaling; K lymphocyte; Knock-out; Knockout; Knockout Mice; Laboratories; Light; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Murine; Mus; Mutate; NK Cells; Natural Killer Cells; Normal Cell; Null Mouse; Phenotype; Photoradiation; Process; Production; Proteins; RNA Expression; Rearrangement; Regulation; Relative; Relative (related person); Reticuloendothelial System, Bone Marrow; Role; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Targetings, Gene; Testing; Transcription; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transgenes; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; autoimmune disorder; base; biological signal transduction; dosage; gene product; insight; malignancy; mutant; neoplasm/cancer; pathogen; prevent; preventing; progenitor; public health relevance; response; social role; transcription factor",Regulation of B Cell Identity and Lineage Progression," Project Narrative Early B cell Factor (EBF1) is essential for the production of B lymphocytes, which produce antibodies in response to foreign pathogens. Here, we will determine how EBF1 regulates the development of these cells in bone marrow. We will also address how EBF prevents the expression of genes of other types of hematopoietic cells, resulting in the commitment of progenitors to become B cells. Our studies are important for understanding how EBF controls these processes in normal cells, autoimmune diseases and cancer.",81878,ZRG1,Special Emphasis Panel,A1,1,390000,
7899713,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI082266-01A2,,NIAID:376220;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IRVINE,UNITED STATES,NEUROLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"DEMETRIOU, MICHAEL ;",7046346;,1R01AI082266,02/01/2010,01/31/2014,"Affinity; Alleles; Allelomorphs; Atrophic Arthritis; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); Carbohydrates; Causality; Cell Communication and Signaling; Cell Function; Cell Growth Inhibitors; Cell Process; Cell Signaling; Cell Surface Glycoproteins; Cell physiology; Cell surface; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Complex; Complexes, Macromolecular; D-Galactoside-Binding Lectin; DNA; Data; Defect; Deoxyribonucleic Acid; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Endocytosis; Environment; Etiology; Galactose Binding Lectin; Galaptins; Galectins; Gene Expression; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Glycans; Glycoproteins; Golgi; Golgi Apparatus; Golgi Complex; Growth Inhibitors; Haplotypes; Human; Human, General; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IDD; IDDM; Immune; Individual; Inflammatory Arthritis; Insulin-Dependent Diabetes Mellitus; Intracellular Communication and Signaling; Lectins, S-Type; Life; MHC Receptor; MS (Multiple Sclerosis); Macromolecular Complexes; Macromolecular Structure; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane Glycoproteins; Metabolic; Metabolic Glycosylation; Mice; Molecular; Molecular Interaction; Molecular Structure; Multiple Sclerosis; Murine; Mus; Mutation; Pathway interactions; Polymorphism (Genetics); Polymorphism, Genetic; Polysaccharides; Protein Glycosylation; Proteins; Receptors, Antigen, T-Cell; Regulation; Rheumatoid Arthritis; Risk; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subcellular Process; Supplementation; Surface; Surface Glycoproteins; T-Cell Receptor; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Therapeutic; Thymus-Dependent Lymphocytes; Type 1 diabetes; Variant; Variation; autoimmune disorder; beta-D-Galactosyl-Specific Lectin; beta-Galactoside Binding Lectin; biological signal transduction; cell growth; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gene product; genetic variant; genome mutation; glycosylation; human disease; insular sclerosis; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; pathway; polymorphism; prevent; preventing; public health relevance; self recognition (immune); sugar; synergism; thymus derived lymphocyte; type I diabetes",Human Autoimmunity and Genetic Defects in N-Glycosylation," Multiple Sclerosis and Type 1 Diabetes are autoimmune diseases resulting from complex interactions between genetic background of the individual and his/her environment. Our combined data suggests that genetic deficiency in a pathway that controls the addition of specific sugars to proteins (i.e. protein glycosylation) leads to immune hyperactivity and promotes autoimmunity in mice and humans. Metabolically supplementing the pathway with a simple sugar suppresses immune hyperactivity and development of autoimmunity, suggesting human disease may be treated/prevented with metabolic therapy.",82266,ICI,Intercellular Interactions,A2,1,376220,
7882058,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI083252-01A1,,NIAID:303005;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ANN ARBOR,UNITED STATES,ANATOMY/CELL BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"TSAI, BILLY ;",8026233;,1R01AI083252,02/01/2010,01/31/2015,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; AMF Receptor; AMF-R; AMFR; AMFR Protein; APF-1; ATP-Dependent Proteolysis Factor 1; Address; Animals; Assay; Autocrine Mobility Factor Receptor; Bacterial Toxins; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Cytoplasm; Cytosol; Data; Death; Diarrhea; Disease; Disorder; Disulfide Interchange Enzyme; Disulfide Isomerase; E3 Ligase; E3 Ubiquitin Ligase; ERp59 PDI; Endoplasmic Reticulum; Epithelial Cells; Ergastoplasm; Erp59; GP78; GSBP; Glycosylation Site-Binding Protein; HMG-20; Health; High Mobility Protein 20; Hydrogen Oxide; Infection; Intestinal; Intestines; Intoxication; Intracellular Communication and Signaling; Lead; Lectin, Castor Bean; Lectin, Ricinus; Lytotoxicity; Macropain; Macroxyproteinase; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Molecular; Molecular Interaction; Molecular Target; Multicatalytic Proteinase; PDI; Pathogenicity Factors; Pathologic; Pathway interactions; Pb element; Peptides; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Disulfide Isomerase; Protein Trafficking; Proteins; Proteosome; RCA 60; RCA60; RNF45; Ricin; Ricinus Communis Agglutinin II; Ricinus Toxin; Role; S-S rearrangase; Shiga Toxin; Shigella Cytotoxin; Shigella Toxin; Signal Transduction; Signal Transduction Systems; Signaling; Stx Protein; Stx Protein, Shigella dysenteria; Subcellular Process; Sulfhydryl-Disulfide Interchange Enzyme; Surface Proteins; Therapeutic Intervention; Thiol-Disulfide Transhydrogenase; Toxin; Traffickings, Protein; Trypanothione-Glutathione Thioltransferase; Ubiquitin; Ubiquitin-Protein Ligase E3; V. cholerae; V.cholerae; Vibrio cholerae; Vibrio comma; Virulence Factors; Water; aberrant protein folding; abnormal protein folding; autocrine motility factor receptor; base; biological signal transduction; bowel; cytotoxicity; disease/disorder; dsbA Gene Product; dsbA Protein; dsbC Gene Product; dsbD Gene Product; gene product; heavy metal Pb; heavy metal lead; human disease; insight; intervention therapy; membrane structure; multicatalytic endopeptidase complex; neuroleukin receptor GP78; novel; pathogen; pathologic protein folding; pathway; protein mis-folding; protein misfolding; protein transport; public health relevance; social role; therapeutic target; tumor autocrine motility factor receptor; ubiquitin-protein ligase; xprA Gene Product",Mechanism of cholera toxin retro-translocation," Project narrative Cholera toxin (CT) causes pathologic water secretion (i.e. diarrhea) in animals, which can lead to death in severe cases. A decisive step in the toxin-dependent infection process is transport of the toxin across the membrane of a sub-cellular compartment known as the endoplasmic reticulum (ER). However, the molecular details by which CT penetrate the ER membrane is not clear. We intend to clarify these process in this proposal.",83252,HIBP,Host Interactions with Bacterial Pathogens Study Section,A1,1,303005,
7884058,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI083279-01A1,,NIAID:377750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","SHAPIRO, VIRGINIA SMITH;",1933354;,1R01AI083279,01/15/2010,12/31/2014,"ATGN; Alleles; Allelomorphs; Antigens; Apoptosis; Apoptosis Pathway; Blood leukocyte; CD25; CD28; CD28 gene; Cell Communication and Signaling; Cell Cycle Progression; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Maturation; Cell Signaling; CellLine; Cells; Chemosensitization; Chemosensitization/Potentiation; Complement; Complement Proteins; Complex; DTX1; DTX1 Protein; Defect; Deltex Homolog 1; Deltex Protein 1; Deltex-1; Deltex1; Development; Drugs, Nonproprietary; Emigrant; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; FLR; Failure (biologic function); Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Generations; Generic Drugs; Genetic; IL2R; IL2RA; IL2RA gene; Immune; Immune response; Intracellular Communication and Signaling; Knockout Mice; Leukocytes; Libraries; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Marrow leukocyte; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Null Mouse; Play; Potentiation; Proteins; Receptors, Antigen, T-Cell; Regulation; Repression; Reticuloendothelial System, Leukocytes; Role; Signal Transduction; Signal Transduction Systems; Signaling; Staging; T-Cell Activation; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T44; TCGFR; Targetings, Gene; Thymocyte Development; Thymus-Dependent Lymphocytes; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Up-Regulation; Up-Regulation (Physiology); Upregulation; White Blood Cells; White Cell; biological signal transduction; cultured cell line; failure; gene product; generic; hDTX1; hDx-1; host response; immunogen; immunoresponse; in vivo; mutant; notch; notch protein; notch receptors; novel; public health relevance; social role; thymocyte; thymus derived lymphocyte; white blood cell; white blood corpuscle",Regulation of T cell development and maturation by NKAP," Project Narrative: T cells are critical to proper generation of the immune response, as failure to produce T cells results in severe immune deficiency. Mice deficient in the protein NKAP have a severe block in the generation of T cells. This proposal will focus on understanding how NKAP regulates T cell development and maturation.",83279,ZRG1,Special Emphasis Panel,A1,1,377750,
7886121,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI083313-01A1,,NIAID:392500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"DEEPE, GEORGE S.;",1873095;,1R01AI083313,02/01/2010,01/31/2015,"Abbreviations; Antifungal Agents; Antifungal Drug; Appearance; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor 1 Gene; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF-1 Gene; BSF1; BSF1 (B cell stimulating factor 1); BSF1 Gene; Basophilic Granulocyte; Basophilic Histiocyte; Basophilic Leukocyte; Basophils; Basophils, Tissue; Binding; Binding (Molecular Function); Binetrakin; Blood Basophil; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood granulocytic cell; Bone Marrow; C-C Chemokines; CC chemokine receptor 2; CCL2; CCL2 gene; CCL7; CCL7 gene; CCL8; CCL8 gene; CCR2 protein; CIS protein; CIS-1 Protein; CISH; CISH Protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Function; Cell Lineage; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemokines, CC; Colony-Stimulating Factors; Colony-forming units; Communicating Junction; Cytofluorometry, Flow; Cytokine Inducible SH2-Containing Protein; Cytokine Network; Cytokine Network Pathway; Cytokine-Inducible Inhibitor of Signaling Type 1B; Cytokines, Chemotactic; Data; Defect; Dendritic Cells; Dysfunction; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Evolution; FLR; Failure (biologic function); Fatal Outcome; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Functional disorder; Fungicides, Therapeutic; G18; GDCF-2; GDCF-2 HC11; GFP; Gap Junctions; Generations; Goals; Grant; Granular Leukocytes; Granulocytic cell; Green Fluorescent Proteins; HC11; HC14; Heterophil Granulocyte; Histocompatibility Complex; Histocompatibility Complices; Histoplasma capsulatum; Homologous Chemotactic Cytokines; Host Defense; Host resistance; Human; Human, General; IFN; IL-4; IL-4 Gene; IL4; IL4 Protein; IL4 gene; INFLM; Immune; Immune response; Immunity; Immunocompetent; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Situ; In Vitro; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Intercrines; Interferons; Interleukin-4; Interleukin-4 Gene; Interleukin-4 Precursor; Interleukin-4 Precursor Gene; Interleukins; Intracellular Communication and Signaling; Intravenous; Investigation; Knowledge; Life; Ligands; Link; Low-resistance Junction; Lung; Lymphocyte Stimulatory Factor 1; MARC; MCAF; MCGF-2; MCP-1; MCP-2; MCP-3; MCP1; MCP2; MCP3; MGC9434; MGI-1 Protein; Major Histocompatibility Complex; Major Histocompatibility Complices; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Basophil; Marrow Mast Cell; Marrow Neutrophil; Mast Cell Growth Factor-2; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Microfluorometry, Flow; Moab, Clinical Treatment; Molecular; Molecular Interaction; Monoclonal Antibodies; Monocyte Chemoattractant Protein-1; Monocyte Chemoattractant Proteins; Monocyte Chemotactic Protein 3; Monocyte Chemotactic Protein-1; Monocyte Chemotactic Proteins; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Mononitrogen Monoxide; Murine; Mus; Myelogenous; Myeloid; Myeloid Cell-Growth Inducer; NC28; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nexus; Nexus Junction; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organism; PCR; Pathogenesis; Pathway interactions; Phagocytes; Phagocytic Cell; Physiopathology; Polymerase Chain Reaction; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Predisposition; Property; Property, LOINC Axis 2; Receptor Protein; Relative; Relative (related person); Research; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Role; SCYA10; SCYA2; SCYA7; SCYA8; SIS cytokines; SMC-CF; SOCS; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A2; Small Inducible Cytokine A7; Small Inducible Cytokine A8; Source; Southeast U.S.; Southeast US; Southeastern United States; Subcellular Process; Suppressor Cells; Suppressor of Cytokine Signaling; Suppressor-Effector T-Lymphocytes; Surface; Susceptibility; T Suppressor Cell; T-Cell Growth Factor 2; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocytes, Suppressor-Effector; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Thymus-Dependent Lymphocytes; Time; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Veiled Cells; Work; Yeasts; amebocyte; anti-fungal; antifungals; beta-Chemokines; biological signal transduction; chemoattractant cytokine; chemokine; chemokine (C-C motif) ligand 8; chemokine receptor; cytokine; endothelial cell derived relaxing factor; failure; flow cytophotometry; fungus; granulocyte; host response; human disease; immunoresponse; immunosuppressed; immunosuppressed patient; in vivo; intraperitoneal; living system; macrophage; mast cell; mastocyte; microbial; monocyte chemoattractant protein-2; monocyte chemoattractant protein-3; monocyte chemotactic activating factor 3; monocyte chemotactic activating factor-2; monocyte chemotactic protein-2; neutrophil; pathophysiology; pathway; public health relevance; pulmonary; receptor; receptor 2, CC chemokine; residence; social role; suppressor T lymphocyte; thymus derived lymphocyte; tumor necrosis factor (unspecified); unspecified interleukin",Chemokine-Cytokine Nexus in Fungal Immunity," Project narrative This grant seeks to understand the interaction between two types of soluble mediators known as chemokines and cytokines in host resistance to a fungus that causes human disease, Histoplasma capsulatum. This fungus which is found world-wide is a serious cause of lung infection in both normal humans and those who have impaired immunity. Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive.",83313,IHD,Immunity and Host Defense Study Section,A1,1,392500,
7793268,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI083663-01A1,,NIAID:370639;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IRVINE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"RAFFATELLU, MANUELA ;",8643843;,1R01AI083663,01/15/2010,12/31/2014,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Africa South of the Sahara; Anti-Retroviral Agents; Antiretroviral Agents; Arm; Bacteremia; Bacteria; Bacterial Infections; Benign; Blood; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; CTLA-8; CTLA8; Costs and Benefits; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Defect; Diarrhea; Fe element; Gastroenteritis; Goals; Gut Inflammation; Heterophil Granulocyte; Homologous Chemotactic Cytokines; IL-17; IL-17A; IL-22; IL17; IL17 Protein; IL17A; INFLM; Immune response; Immunocompetent; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Individual; Infection; Infection prevention; Inflammation; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Intestinal; Intestinal Inflammation; Intestinal Mucosa; Intestines; Iron; Lead; Life; Localized Disease; Macaca mulatta; Mammals, Mice; Marrow Neutrophil; Mediating; Mice; Mortality; Mortality Vital Statistics; Mucosa; Mucosal Inflammation; Mucosal Tissue; Mucositis; Mucous Membrane; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Outcome; Outcome Study; Pathogenesis; Patients; Pb element; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prevent infection; Research; Resistance; Reticuloendothelial System, Blood; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk; Role; S. typhimurium; S.typhimurium; SIS cytokines; Salmonella; Salmonella infections; Salmonella typhimurium; Salmonellosis; Serotyping; Study, Outcome; Sub-Saharan Africa; Subsaharan Africa; Surface; Systemic infection; Testing; Transmission; United States; Upper arm; Western Europe; Work; anti-microbial; anti-retroviral; antimicrobial; antimicrobial peptide; antiretroviral; bacteraemia; bacterial disease; base; bowel; chemoattractant cytokine; chemokine; cytokine; expectation; heavy metal Pb; heavy metal lead; high risk; host response; immunoresponse; immunosuppressed patient; innovate; innovation; innovative; interleukin-22; neutrophil; pathogen; prevent; preventing; public health relevance; resistant; response; secondary immune deficiency; social role; transmission process; trend",Mucosal barrier function during Salmonella infection,"  Salmonella typhimurium causes inflammatory diarrhea in immunocompetent individuals, while in immunocompromised patients it causes bacteremia with a high mortality rate. Very little is known about which mucosal inflammatory responses constitute the mucosal barrier to systemic Salmonella dissemination and which are exploited by Salmonella to colonize the gut. Our long-range goal is to understand how the intestinal mucosal barrier functions as well as how it is altered in individuals at higher risk for systemic infections.",83663,HIBP,Host Interactions with Bacterial Pathogens Study Section,A1,1,370639,
7889199,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI083901-01A1,,NIAID:424925;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MANHASSET,UNITED STATES,,05,110565913,US,NY,11030,FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH,"DAVIDSON, ANNE ;",1973352;,1R01AI083901,02/01/2010,01/31/2015,"Address; Affinity; Alferon; Alleles; Allelomorphs; Anti-Phospholipid Antibodies; Anti-Phospholipid Antibody Syndrome; Anti-Phospholipid Syndrome; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Anticoagulation; Antigen-Antibody Complex; Antiphospholipid Antibodies; Antiphospholipid Antibody Syndrome; Antiphospholipid Syndrome; Antirejection Therapy; Apoptosis; Apoptosis Pathway; Apoptotic; Autoantibodies; Autoimmune; Autoimmune Process; B blood cells; B cell activating factor; B cell repertoire; B lymphocyte stimulator; B-Cell Activation; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; BAFF ligand; BAFF protein; BLyS protein; Blood Clot; Blood Clotting; Blood Plasma Cell; Blood Serum; Blood coagulation; Body Tissues; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cardiolipins; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Maturation; Cell Signaling; Cell Survival; Cell Viability; Cells; Ceramide (lipids); Ceramides; Chimera; Chimera organism; Class Switching; Clinical; Clinical Trials; Clinical Trials, Unspecified; Closure by Ligation; Clotting; Coagulation; Coagulation Process; Complement; Complement Proteins; Data; Dendritic Cells; Development; Disease; Disorder; Endosomes; Endothelial Cells; Endothelium; Event; Familial antiphospholipid syndrome; Fc Receptor; FcR; Female; Fostering; G-interferon; GWAS; Gamma Globulin, 7S; Gene Products, RNA; General Population; General Public; Genes; Genetic; Ginterferon; Goals; Human; Human, General; Hypercoagulability; IFN; IFN Alpha; IFNa; INFLM; IRAK; IRAK1; IRAK1 gene; IgG; Immune Complex; Immune Function, Cellular; Immune response; Immune system; Immunoglobulin Class Switching; Immunoglobulin G; Immunosuppressive Therapy; Individual; Inflammation; Inflammation Mediators; Interferon Alfa-n3; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Interferons; Intracellular Communication and Signaling; Intracellular Second Messengers; Isotype Switching; Ligation; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Mice; Murine; Mus; Myelogenous; Myeloid; Nephritis; Nucleic Acids; Outcome; Pathogenicity; Pathway interactions; Patients; Phosphatides; Phospholipids; Plasma Cells; Plasmacytes; Process; Production; Proliferative Glomerulonephritis; RNA; RNA, Non-Polyadenylated; Receptosomes; Recurrence; Recurrent; Regulation; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Risk; Role; SLE; SLE - Lupus Erythematosus, Systemic; STAT4; STAT4 gene; Second Messenger Systems; Second Messengers; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stress; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; Syndrome; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T-Cell Activation; T-Cells; T-Lymphocyte; TALL-1 protein; TALL1; THANK protein; TLR7; TLR7 gene; TNFSF13B protein; TNFSF20 protein; Testing; Therapeutic immunosuppression; Therapy, Anti-Rejection; Thrombocytopenia; Thrombopenia; Thrombophilia; Thrombosis; Thrombus; Thymus-Dependent Lymphocytes; Tissues; To autoantigen; Transgenic Organisms; Up-Regulation; Up-Regulation (Physiology); Upregulation; Veiled Cells; acid sphingomyelinase; antibody biosynthesis; antibody receptor; artificial immunosuppression; autoimmune antibody; autoreactive B cell; base; biological signal transduction; body system, allergic/immunologic; clinical investigation; cytokine; disease/disorder; disseminated lupus erythematosus; effective therapy; experiment; experimental research; experimental study; fetal; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; host response; human disease; immune function; immunoglobulin biosynthesis; immunoresponse; immunosuppression; in vivo; male; mouse model; necrocytosis; new therapeutics; next generation therapeutics; novel therapeutics; organ system, allergic/immunologic; overexpression; particle; pathway; pelle; plasmocyte; public health relevance; research study; response; second messenger; self reactive antibody; social role; systemic lupus erythematosis; thymus derived lymphocyte; transgenic; whole genome association studies; whole genome association study; zTNF4",Regulation of the anti-phospholipid response in SLE," Antiphospholipid syndrome (APS) is a devastating autoimmune condition that causes recurrent blood clots and has no effective treatment apart from lifelong anticoagulation. In patients with lupus anti-phospholipid antibodies are found more commonly and are associated clinical thromboses more often than in the general population. There is very little currently known about how the antibodies that cause APS are regulated. We use a mouse model of APS that has many similarities to the human disease. We will study the role of major components of the immune response in regulating the initiation and perpetuation of the autoimmune antibody response to phospholipids and will determine how inflammation in SLE patients triggers clotting events. Because there is a dearth of clinical trials for APS, an increased understanding of the role of the immune system in causing APS may form the basis for a rational clinical trial in this disease.",83901,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",A1,1,424925,
7800614,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI084041-01A1,,NIAID:413507;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"ERNST, JOEL D.;",1864687;,1R01AI084041,01/15/2010,12/31/2014,"AIDS Virus; APC; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Adjuvant; Antigen Presentation; Antigen-Presenting Cells; Antigens; Bacteria; Bone Marrow; Bypass; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cells; Cells, CD4; Chronic; Class II Antigens; Class II Major Histocompatibility Antigens; Communicable Diseases; Complex; Data; Dendritic Cells; Detection; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Resistant Tuberculosis; Drug resistance; Drugs; Exhibits; Extreme drug resistant tuberculosis; Extremely drug resistant tuberculosis; Frequencies (time pattern); Frequency; Future; Genes; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Granuloma; Granulomatous Lesion; HIV; HTLV-III; Histocompatibility Antigens Class II; History; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; I-A Antigen; Ia Antigens; Ia-Like Antigens; Imagery; Immune; Immune Response Antigens; Immune response; Immune-Response-Associated Antigens; Immunity; Immunologic Accessory Cells; In Vitro; Individual; Infection; Infection Control; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; LAV-HTLV-III; Lung; Lymphadenopathy-Associated Virus; M. tb; M. tuberculosis; M. tuberculosis antigen 85B; M.tb; M.tuberculosis; MHC Class II; MHC Class II Genes; MHC Class II Molecule; MHC Class II Protein; MHC Receptor; MHC class II antigen; MT 85B antigen complex; Major Histocompatibility Complex Class II; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Methods; Mice; Minority; Moab, Clinical Treatment; Monoclonal Antibodies; Monocytes / Macrophages / APC; Multidrug-Resistant Tuberculosis; Murine; Mus; Mycobacterium tuberculosis; Mycobacterium tuberculosis antigen 85B; Myelogenous; Myeloid; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Public Health; Publications; Reaction Time; Reagent; Receptors, Antigen, T-Cell; Recombinants; Recording of previous events; Reporting; Resistance; Respiratory System, Lung; Response RT; Response Time; Reticuloendothelial System, Bone Marrow; Scientific Publication; Site; Staging; System; System, LOINC Axis 4; T-Cell Receptor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TB vaccine; Testing; Thymus-Dependent Lymphocytes; Transgenic Organisms; Tuberculosis; Tuberculosis Vaccines; Tuberculosis, Drug Resistance; Tuberculosis, Drug Resistant; Tuberculosis, MDR; Tuberculosis, Multi-Drug Resistant; Tuberculosis, MultiDrug Resistance; Tuberculosis, Multidrug-Resistant; Vaccines; Veiled Cells; Virus-HIV; Visualization; XDR-Tuberculosis; accessory cell; anti-TB vaccine; antigen 85B, Mycobacterium tuberculosis; attenuation; base; disease/disorder; disseminated TB; disseminated tuberculosis; drug resistant; drug/agent; experiment; experimental research; experimental study; fbpB protein, Mycobacterium tuberculosis; helper T cell; host response; immune clearance; immunogen; immunoresponse; improved; in vivo; insight; macrophage; mouse model; mycolyl transferase 30; new approaches; novel; novel approaches; novel strategies; novel strategy; pMHC; pandemic; pandemic disease; prevent; preventing; psychomotor reaction time; public health medicine (field); public health relevance; pulmonary; research study; resistance to Drug; resistant; resistant to Drug; response; success; thymus derived lymphocyte; tool; transgenic; tuberculous spondyloarthropathy",Mycobacterium tuberculosis evasion of CD4+ T cells in vivo," One of the major problems that has prevented development of a successful TB vaccine is that the bacteria that cause TB are not eliminated by normal immune responses. In this project, we will identify and characterize the mechanisms that TB bacteria use to avoid recognition and elimination by immune cells. We expect that understanding these mechanisms will allow us and others to develop novel ways to increase resistance of people to tuberculosis.",84041,IHD,Immunity and Host Defense Study Section,A1,1,413507,
7750721,R01,AI,1,,02/01/2010,01/31/2011,PAR-08-130,1R01AI084315-01,,NIAID:110484;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW DELHI,INDIA,,,650304194,IN,,,PUBLIC HEALTH FOUNDATION OF INDIA,"DANDONA, LALIT ;",9706057;,1R01AI084315,02/01/2010,01/31/2014,"21+ years old; AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Adult; Analysis, Data; Anti-Retroviral Agents; Antiretroviral Agents; Blood Sample; Blood specimen; Boxing; Caring; Cohort Studies; Concurrent Studies; Confidence Intervals; Confidentiality; Counseling; Data; Data Analyses; Data Collection; Data Set; Dataset; Ensure; Ethics; Fingers; Follow-Up Studies; Followup Studies; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; HHV-2; HIV; HIV Infections; HIV Prevention; HIV Seroprevalence; HIV test; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HSV-2; HSV2; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Herpes Simplex Virus 2; Herpes Simplex Virus Type 2; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus progenitalis; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human herpes simplex virus type 2; Human immunodeficiency virus test; Human, Adult; Incidence; India; Individual; Industry; Infection; Intervention; Intervention Strategies; Interview; LAV-HTLV-III; Laboratories; Longitudinal Studies; Lymphadenopathy-Associated Virus; Marital Status; MeSH Descriptors Class 4; Methods; Methods and Techniques; Methods, Other; Migrant; Nomads; Paper; Participant; Patient Self-Report; Persons; Pilot Projects; Population; Prevention; Procedures; R01 Mechanism; R01 Program; RPG; Reporting; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Risk; Risk Behaviors; Risky Behavior; Rural; STD; Sample Size; Sampling; Self-Report; Services; Sex Behavior; Sexual Activity; Sexual Behavior; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Social Desirabilities; Social Desirability; Supportive Therapy; Supportive care; Syphilis; T-Lymphotropic Virus Type III Infections, Human; Techniques; Testing; Time; Training; Transmission; Validity of Self Report; Venereal Diseases; Venereal Disorders; Venereal Infections; Vertical Disease Transmission; Vertical Transmission; Virus-HIV; Woman; Work; adult human (21+); anti-retroviral; antiretroviral; at risk behavior; base; cohort; design; designing; evidence base; experiment; experimental research; experimental study; follow-up; geographic site; great pox; herpes simplex ii; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; human alphaherpesvirus 2; interventional strategy; long-term study; men; men who have sex with men; men who have sex with other men; men's; mother to child transmission; pilot study; population based; privacy of information; public health relevance; research study; response; risky sexual behavior; sex; sex activity; transmission process; uptake",Assessment of HIV incidence and its determinants in a population-based longitudin," PROJECT NARRATIVE This is the first study in India that will follow-up a representative sample of the population to provide original data and analysis of new HIV infections and their determinants at the population level, bias in sexual behavior reporting, and barriers to HIV interventions. Rigorous scientific methods will be used for field data collection, laboratory analysis and statistical analysis. This study will fill several crucial gaps in the evidence base needed for the understanding of HIV transmission and its control in high burden parts of India.",84315,ZRG1,Special Emphasis Panel,,1,110484,
7897115,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI084913-01A1,,NIAID:377500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MASOPUST, DAVID ;",2545214;,1R01AI084913,02/01/2010,01/31/2015,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Alimentary Canal; Anatomic; Anatomical Sciences; Anatomy; Antigens; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Differentiation; Cell Differentiation process; Cell Locomotion; Cell Migration; Cell Movement; Cells, CD4; Cellular Migration; Cues; Development; Developmental Process; Digestive Tract; Exposure to; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Genital; Genital system; Goals; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Homing; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunity; Infection; Knowledge; LAV-HTLV-III; LYT3; Location; Lymphadenopathy-Associated Virus; Lymphatic Tissue; Lymphoid Tissue; Maintenance; Maintenances; Memory; Motility; Motility, Cellular; Mucosa; Mucosal Tissue; Mucous Membrane; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Regulation; Role; Science of Anatomy; Site; Surface; T memory cell; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Tissues; Vaccination; Vaccine Design; Vaccines; Virus-HIV; Work; alimentary tract; anatomy; cell motility; cytokine; design; designing; digestive canal; experience; gastrointestinal; helper T cell; immunogen; memory T lymphocyte; mouse model; mucosal site; pathogen; programs; public health relevance; rectal; social role; thymus derived lymphocyte; trafficking; urogenital system (genital part); vaccination strategy",Mucosal T Cell Memory to Pathogens," Project Narrative. Mucosal tissues represent the most common site of infections. These studies will examine how the establishment, maintenance, and differentiation of memory CD8 T cells is regulated within mucosal tissues, and will test the ability of mucosal memory CD8 T cells to protect the host upon local exposure to intracellular pathogens. Achieving these aims will benefit the design of CD8 T cell vaccines.",84913,CMIB,Cellular and Molecular Immunology - B Study Section,A1,1,377500,
7887403,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI085015-01A1,,NIAID:393599;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"ROSS, SUSAN R;",1868816;,1R01AI085015,02/01/2010,01/31/2015,"2(1H)-Pyrimidinone, 4-amino-; AIDS Virus; APOBEC3G, human; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adeno-Associated Viruses; Affect; Antiviral Agents; Antiviral Drugs; Antivirals; Apo-B; ApoB; Apolipoproteins B; B blood cells; B-Cells; B-Lymphocytes; Biological Models; Bittner Virus; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CEM15 protein, human; Cells; Complex; Cultured Cells; Cytidine; Cytosine; Cytosine Ribonucleoside; Cytosine Riboside; DNA; Deamination; Deoxyribonucleic Acid; Dependovirus; Development; Epithelial Cells; Eukaryota; Eukaryote; Evolution; Family; Foamy Virus; Gene Deletion; Genes; Genetic Polymorphism; Genome; Genome, Human; HBV; HIV; HIV Infections; HIV-1; HIV-I; HIV1; HPV; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatitis B Virus; Hepatitis Virus, Homologous Serum; Human; Human Genome; Human Immunodeficiency Viruses; Human Papillomavirus; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Immune; Immunodeficiency Virus Type 1, Human; In Vitro; Infection; Infection Control; Infectious Agent; Infectious Human Wart Virus; Knockout Mice; LAV-HTLV-III; Lactation; Lymphadenopathy-Associated Virus; Lymphatic Tissue; Lymphoid; Lymphoid Tissue; MMTV; Mammals, Mice; Mammary Cancer Virus; Mammary Glands, Human; Mammary Tumor Virus, Mouse; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Milk; Model System; Models, Biologic; Monkeys; Mouse Mammary Tumor Virus; Murine; Mus; Null Mouse; Organism; Papilloma Virus, Human; Papillomavirus, Human; Pathway interactions; Play; Polymorphism (Genetics); Polymorphism, Genetic; Prokaryotae; Prokaryotic Cells; Protein Family; Proteins; Retroviridae; Retroviridae Infections; Retroviridae disease; Retrovirus Infections; Retroviruses; Role; SIV; Simian Immunodeficiency Viruses; Spumavirus; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Tissues; Transmission; Tumor Virus Infections; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Physiology; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Virus-HIV; Virus-Retrovirus; Viruses, General; adeno associated virus group; base; eukaryotida; experiment; experimental research; experimental study; gene deletion mutation; gene product; human CEM15 protein; human T cell leukemia virus III; human T lymphotropic virus III; human tissue; in vivo; infectious organism; insight; interest; living system; mammary; mammary tumor virus; milk agent; mouse model; pathway; polymorphism; prokaryote; protein function; public health relevance; research study; response; social role; transmission process; viral infection; virus infection; virus multiplication; wart virus",Role of APOBEC3 in in vivo Restriction of Retrovirus Infection," This project will investigate a newly discovered anti-viral host restriction factor, APOBEC3, which inhibits HIV-1  infection. Our experiments will take advantage of a unique mouse model developed by our lab to examine the  role of APOBEC3 in restricting infection by the murine retrovirus mouse mammary tumor virus in vivo. These  studies will provide insight into how APOBEC3 proteins inhibit infection by human retroviruses such as HIV-1 in  an experimentally tractable mouse model. ",85015,VIRA,Virology - A Study Section,A1,1,393599,
7899537,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI085046-01A1,,NIAID:385000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,INDIANAPOLIS,UNITED STATES,PEDIATRICS,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"ZHOU, BAOHUA ;",7549356;,1R01AI085046,01/15/2010,12/31/2014,"ATGN; Affect; Allergens; Allergic; Allergic Disease; Allergic asthma; Allergic inflammation; Allergic rhinitis; Allergic rhinitis due to allergen; Allergic rhinosinusitis; Allergy; Animals; Antibodies; Antigens; Aspiration, Respiratory; Asthma; Atopic Dermatitis; Atopic rhinitis; Bone Marrow; Breathing; Bronchial Asthma; CD154; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD40L; CD40LG; Causality; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Data; Dendritic Cells; Dermatitis, Atopic; Development; Disease; Disorder; Dose; Eczema, Atopic; Environmental Factor; Environmental Risk Factor; Epithelial Cells; Etiology; Extrinsic asthma; Generations; Genes; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Goals; Health; Human; Human, General; Hypersensitivity; Immune response; Immunity; In Vitro; Individual; Inhalation; Inhaling; Inherited Predisposition; Inherited Susceptibility; Inspiration, Respiratory; Intracellular Communication and Signaling; Laboratories; Lead; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Mice; Modeling; Murine; Mus; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; Pathogenesis; Pb element; Play; Prevalence; Prevention; Preventive Intervention; Receptor Protein; Regulatory T-Lymphocyte; Research; Reticuloendothelial System, Bone Marrow; Retroviridae; Retroviruses; Rhinitis allergic atopic; Role; Signal Transduction; Signal Transduction Systems; Signaling; Societies; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TNFSF5; TNFSF5 gene; TRAP Gene; TSLP; TSLP cytokine; TSLP gene; TSLP protein, human; Testing; Th-2 Cell; Th2 Cells; Thymic Stromal Lymphopoietin; Thymic Stromal Lymphopoietin Protein TSLP; Type 2 Helper Cell; Veiled Cells; Virus-Retrovirus; Wild Type Mouse; Work; allergic airway epithelium inflammation; allergic airway inflammation; allergic dermatitis; allergic eczema; allergic response; atopic asthma; base; biological signal transduction; clinical relevance; clinical significance; clinically relevant; clinically significant; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environmental risk; extrinsic allergic asthma; genetic etiology; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; helper T cell; host response; human TSLP protein; immunogen; immunoresponse; in vivo; innovate; innovation; innovative; inspiration; memory recall; overexpression; prevent; preventing; preventional intervention strategy; public health relevance; receptor; response; social role; therapeutic target",TSLP in Th2 Immunity and Allergic Airway Inflammation,"  Our proposed research mainly deals with the early steps of allergen sensitization that will advance our understanding of the pathogenesis of asthma and allergy. Studies on the generation and maintenance of Th2 memory, and using antibody blockade to dampen Th2 memory are of clinical relevance which might be translatable to control and/or prevent asthma in humans.",85046,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",A1,1,385000,
7769000,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI085161-01,,NIAID:337000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NORMAN,UNITED STATES,CHEMISTRY,04,848348348,US,OK,730195300,UNIVERSITY OF OKLAHOMA NORMAN,"CICHEWICZ, ROBERT HENRY;",8773906;,1R01AI085161,01/15/2010,12/31/2014,"Acinetobacter baumannii; Address; American; Americas; Anabolism; Anti-Bacterial Agents; Anti-microbial Drug Resistance; Anti-microbial Drug Resistant; Antibacterial Agents; Antifungal Agents; Antifungal Drug; Antimicrobial Drug Resistance; Antimicrobial Drug Resistant; Antimicrobial resistant; Aspergillus; Aspergillus niger; Assay; Bacteria; Bioassay; Biologic Assays; Biological Assay; Biological Factors; Burkholderia cepacia; Candida; Care, Health; Chemical Fractionation; Chemicals; Clinic; Coliform Bacilli; Complex; Contracting Opportunities; Contracts; Culture Procedure; D-Mannose; Data; Development; Distress; Drug Evaluation, Preclinical; Drug Formulations; Drug Resistance, Microbial; Drug Screening; Drug resistance; Drug, Natural Product; Drugs; ESI; ESI Mass Spectrometry; Economics; Electrospray Ionization; Engineering; Engineerings; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Enterococcus faecium; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Evaluation; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Exhibits; FLR; FRACN; Factor, Biologic; Failure (biologic function); Formulation; Formulations, Drug; Fractionation; Fractionation Radiotherapy; Fungicides, Therapeutic; Future; Gene Cluster; Gene Transcription; Genetic Transcription; Goals; Health; Healthcare; Healthcare Systems; Heart; Human; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Vitro; Incubators; Infection; Infusion; Infusion procedures; Investigation; Investments; Laboratories; Laboratory culture; Lead; Left; Length of Life; Libraries; Life; Longevity; Man (Taxonomy); Man, Modern; Mannopyranose; Mannopyranoside; Mannose; Mass Spectrum; Mass Spectrum Analysis; Medical; Medication; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microbe; Modification; Monilia; Mortality; Mortality Vital Statistics; Natural Product Drug; Natural Products; Oklahoma; P. aeruginosa; P. cepacia; P.aeruginosa; P.cepacia; PROV; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Photometry/Spectrum Analysis, Mass; Play; Position; Positioning Attribute; Preclinical Drug Evaluation; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Provider; Pseudomonas aeruginosa; Pseudomonas cepacia; Pseudomonas pyocyanea; Publishing; RNA Expression; Research; Research Design; Research Resources; Resources; Risk; S. aureus; S. faceium; S. faecium; S.aureus; S.faceium; S.faecium; Sampling; Site; Source; Spectrometry, Mass; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staphylococcus aureus; Streptococcus faceium; Streptococcus faecium; Structure; Study Section; Study Type; System; System, LOINC Axis 4; Systems, Health Care; Techniques; Testing; Therapeutic; Therapeutic Agents; Time; Transcription; Transcription, Genetic; Translating; Translatings; Universities; Work; anti-bacterial; anti-fungal; anti-microbial; anti-microbial agent; anti-microbial drug; antibacterial; antifungals; antimicrobial; antimicrobial agent; antimicrobial drug; base; biosynthesis; combat; commercialization; cost; design; designing; drug development; drug discovery; drug resistant; drug/agent; experience; failure; fungus; heavy metal Pb; heavy metal lead; immunosuppressed patient; innovate; innovation; innovative; intervention development; language translation; life span; lifespan; member; microbial; microbial drug resistance; microbial drug resistant; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathogen; pathway; pharmacophore; preclinical study; programs; public health relevance; resistance to Drug; resistant to Drug; scaffold; scaffolding; small molecule; small molecule libraries; stem; study design; therapeutic development; therapy development; tool; treatment development",Chemically diverse antimicrobials from silent biosynthetic pathways, Narrative These studies are designed to address the need for new antibacterial and antifungal agents for treating a wide range of microbial pathogens. This work is important because fungal secondary metabolites produced from silent biosynthetic pathways represent an untapped reservoir of chemically diverse substances that have immense potential for therapeutic development. The infusion of these structurally diverse compounds into the drug discovery pipeline is expected to have a significant positive impact on human health by providing a rich new source of novel small-molecule leads for combating a variety of bacterial and fungal illnesses.,85161,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,1,337000,
7768244,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI086134-01,,NIAID:417717;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"SACHS, DAVID H;",2436454;,1R01AI086134,01/15/2010,12/31/2014,"21+ years old; Activities of Daily Living; Activities of everyday life; Adolescent; Adolescent Youth; Adult; Age; Aging; Allogenic; Animal Model; Animal Models and Related Studies; Animals; Assay; BRO; Bioassay; Biologic Assays; Biological Assay; Biology; Bone Marrow; Brothers; CAPS; Calcineurin antagonist; Calcineurin inhibitor; Capsules; Cells; Chemotherapy-Hormones/Steroids; Clinical; Clinical, Transplantation, Organ; Cyclosporines; Cyclosporins; Data; Dermatoplasties; Dermatoplasty; Dose; Drugs; Elements; Endocrine Gland Secretion; Environment; Goals; Grafting Procedure; Histologic; Histologically; Home; Home environment; Hormonal; Hormones; Host Factor; Host Factor Protein; Human; Human, Adult; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; IL-7; IL7 Protein; Immune response; Immunologic, Immunochemical; Immunologics; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; In element; Inbred Strain; Inbreeding; Indium; Individual; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Integration Host Factors; Interleukin 7 Precursor; Interleukin-7; Kidney; Laboratory Study; Lead; Lobe; Lymphopoietin-1; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow; Measures; Medication; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Miniature Swine; Minipigs; Modeling; Molecular; Natural immunosuppression; Natural regeneration; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiology; Population; Pre-Clinical Model; Preclinical Models; Predisposition; Process; Protocol; Protocols documentation; Protocols, Treatment; RGM; Recombinants; Regeneration; Regimen; Rejuvenation; Relative; Relative (related person); Research; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Rodent; Rodentia; Rodentias; Role; SIS; Senescence; Sister; Skin Transplantation; Skin graft; Somatomedin C; Structure; Susceptibility; Swine, Miniature; Techniques; Testing; Therapeutic Hormone; Thymic Tissue; Thymus; Thymus Gland; Thymus Proper; Time; Tissue Transplantation; Transplantation; Transplantation Surgery; Transplantation Tolerance; Treatment Protocols; Treatment Regimen; Treatment Schedule; Urinary System, Kidney; adult animal; adult human (21+); aged; allogenic skin graft; capsule (pharmacologic); cytokine; daily living functionality; design; designing; drug/agent; experiment; experimental research; experimental study; functional ability; functional capacity; grafting, skin; heavy metal Pb; heavy metal lead; host response; immunoresponse; immunosuppression; immunosuppressive; juvenile; juvenile animal; juvenile human; kidney allograft; mature animal; mini pig; model organism; organ allograft; organ graft; organ xenograft; pre-clinical; preclinical; public health relevance; reconstitute; reconstitution; regenerate; renal; renal allograft; research study; senescent; social role; thymus transplantation; transplant; young animal",Thymic Rejuvenation for the Induction of Transplantation Tolerance," Narrative Studies in a large animal model have demonstrated: 1) that a juvenile thymus is required for the induction of tolerance to vascularized renal allografts by a short course of immunosuppressive drugs; and 2) that the aged thymus can be restored to its juvenile state by transplantation into a young recipient, indicating that factors outside of the thymus are responsible for this rejuvenation. This proposal is directed toward determining what these factors are so that they may be used to rejuvenate the thymus of adult animals and thereby render them susceptible to tolerance induction by the same simple treatment regimen that is effective in juveniles. .",86134,TTT,"Transplantation, Tolerance, and Tumor Immunology",,1,417717,
7839355,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI087135-01,,NIAID:342348;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCHESTER,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"WU, HULIN ;",2138038;,1R01AI087135,01/15/2010,12/31/2013,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adherence; Adherence (attribute); Adverse effects; Algorithms; Antiretroviral Therapy, Highly Active; Arts; Behavior; Biological; Blood Plasma; Clinical; Clinical Data; Clinical Research; Clinical Study; Communities; Computational algorithm; Computer Programs; Computer software; Data; Detection; Development; Discipline; Disease; Disorder; Drug Kinetics; Drug resistance; Drugs; Engineering; Engineerings; Epidemic; Epidemiology; Equation; Gene Products, RNA; Goals; Guidelines; HAART; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immune response; Immunologic Deficiency Syndrome, Acquired; Interdisciplinary Research; Interdisciplinary Study; Intervention; Intervention Strategies; Investigators; Kinetic; Kinetics; LAV-HTLV-III; Lead; Least Squares; Least-Squares Analyses; Least-Squares Analysis; Life; Lymphadenopathy-Associated Virus; Markers, Surrogate; Math Models; Measurement; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Multidisciplinary Collaboration; Multidisciplinary Research; Outcome; Pathogenesis; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Plasma; Preventive Intervention; Property; Property, LOINC Axis 2; Public Health; RNA; RNA, Non-Polyadenylated; Regimen; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Rights; Sampling; Scientist; Serum, Plasma; Software; Solutions; Statistical Methods; Study models; Study, Interdisciplinary; Surrogate Markers; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Techniques; Testing; Therapy, Vaccine; Time; Transmission; Treatment Side Effects; VAC-TX; Vaccine Therapy; Viral Burden; Viral Diseases; Viral Load; Viral Load result; Virus Diseases; Virus-HIV; abstracting; anti-retroviral therapy, highly active; base; computer program/software; cost; data modeling; disease/disorder; drug resistant; drug/agent; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; host response; immunoresponse; improved; innovate; innovation; innovative; interventional strategy; mathematical model; mathematical modeling; new approaches; novel; novel approaches; novel strategies; novel strategy; pandemic; pandemic disease; preventional intervention strategy; public health medicine (field); public health relevance; research study; resistance to Drug; resistant to Drug; side effect; simulation; theories; therapy adverse effect; transmission process; treatment adverse effect; treatment strategy; user friendly computer software; user friendly software; user-friendly; viral infection; virus infection; web site",Estimation Methods for Nonlinear ODE Models in AIDS Research," Impact on Public Health: The developed statistical methods for ODE models of HIV dynamics and AIDS epidemics allow to reliably estimate the unknown kinetic or epidemic parameters of HIV dynamics and AIDS epidemics. These parameters and the ODE models can be used to help HIV/AIDS investigators better understand the biological mechanisms and pathogenesis of HIV infection, which may lead to novel scientific findings and provide guidance to develop treatment strategies.",87135,ACE,AIDS Clinical Studies and Epidemiology Study Section,,1,342348,
7928479,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI087139-01A1,,NIAID:611887;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ESHLEMAN, SUSAN H;",1878926;,1R01AI087139,02/01/2010,01/31/2014,"0-11 years old; 21+ years old; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 6H-Dipyrido(3,2-b[{..}]2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-; AIDS Virus; AIDS prevention; AIDS/HIV prevention; ARV resistance; ARV resistant; AZT; AZT (Antiviral); Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Adult; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Antiretroviral Agents; Antiretroviral Therapy, Highly Active; Antiretroviral drug resistance; Antiretroviral resistance; Antiretroviral resistant; Azidothymidine; Birth; Blood Plasma; Breast Feeding; Breast Milk; Breastfeeding; CD4 Lymphocyte Count; CD4+ Cell Counts; CD4+ Counts; Cells; Child; Child Youth; Children (0-21); Counseling; Country; Data; Development; Diagnosis; Dose; Drugs; ELIG; Eligibility; Eligibility Determination; Enrollment; Exposure to; Funding; Gene Products, RNA; Gestation; Government Programs; HAART; HIV; HIV Infections; HIV Prevention; HIV drug resistance; HIV drug resistant; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human Milk; Human Mother's Milk; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Infant; LAV-HTLV-III; Life; Lymphadenopathy-Associated Virus; Malawi; Mammary Gland Milk; Medication; Milk, Human; Mothers; Nevirapine; Nyasaland; Parturition; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; Postpartum; Postpartum Period; Postpartum Women; Pregnancy; Prevalence; Prevention; Prevention Measures; Prophylactic treatment; Prophylaxis; Protocol Screening; RNA; RNA, Non-Polyadenylated; Randomized; Recommendation; Regimen; Research Resources; Resistance; Resources; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Risk; Sampling; Serum, Plasma; Sub-Saharan Africa; Subsaharan Africa; T-Lymphotropic Virus Type III Infections, Human; T4 Lymphocyte Count; Testing; Therapeutic; Thymidine, 3'-azido-3'-deoxy-; Time; Transmission; Vertical Disease Transmission; Vertical Transmission; Viral Burden; Viral Load; Viral Load result; Viramune; Virus; Virus-HIV; Viruses, General; Visit; Woman; Women, Postpartum; ZDV; Zidovudine; adult human (21+); anti-retroviral; anti-retroviral drug resistance; anti-retroviral drug resistant; anti-retroviral resistance; anti-retroviral resistant; anti-retroviral therapy, highly active; antiretroviral; antiretroviral drug resistant; antiretroviral therapy; azidodeoxythymidine; children; comparative efficacy; design; designing; drug/agent; enroll; feeding; follow-up; improved; intrapartum; mother to child transmission; pediatric human immunodeficiency virus; postnatal; pregnant; public health relevance; randomisation; randomization; randomly assigned; resistance to ARV; resistance to HIV drug; resistance to anti-retroviral; resistance to anti-retroviral drug; resistance to antiretroviral; resistance to antiretroviral drug; resistant; resistant strain; resistant to ARV; resistant to HIV drug; resistant to anti-retroviral; resistant to anti-retroviral drug; resistant to antiretroviral; resistant to antiretroviral drug; theories; transmission process; youngster",Impact of maternal HAART on HIV-infected breastfeeding infants: Malawi," NARRATIVE In resource-limited settings, many HIV-infected women are diagnosed with HIV infection during pregnancy or shortly after delivery, and many begin HIV treatment with antiretroviral drugs while they are still breastfeeding. We will determine whether initiation of treatment in breastfeeding women poses any risk to breastfeeding infants who are HIV-infected, by inducing resistance to antiretroviral drugs in the infant's virus.",87139,ACE,AIDS Clinical Studies and Epidemiology Study Section,A1,1,611887,
7929987,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI087528-01A1,,NIAID:386250;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"TROEMEL, EMILY R;",1928620;,1R01AI087528,01/15/2010,12/31/2014,"0-11 years old; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Animal Model; Animal Models and Related Studies; Animals; Binding; Binding (Molecular Function); Biochemical; Biological Function; Biological Process; C elegans; C.elegans; Caenorhabditis; Caenorhabditis elegans; Cell Components; Cell Function; Cell Process; Cell Structure; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Structures; Cessation of life; Characteristics; Child; Child Youth; Children (0-21); Complement; Complement Proteins; Cues; Death; Detection; Development; Diarrhea; Disease; Disorder; Drugs; Epidemic; Epithelial Cells; Fingers; Genes; Genetic; Genome; Genomics; Goals; Human; Human, Child; Human, General; Image; Imaging Device; Imaging Tool; Immune; Immune response; Immunologic Deficiency Syndrome, Acquired; Infection; Infection Control; Internet; Intestinal; Intestines; Intracellular Structure; Invaded; Label; Libraries; Life; Man (Taxonomy); Man, Modern; Medical; Medication; Methods and Techniques; Methods, Other; Microspora; Microsporidia; Microsporidia (protozoa); Microvillus; Mission; Modeling; Molecular; Molecular Interaction; Names; Natural Resistance; Natural regeneration; Nematoda; Nematodes; Organ; Parasites; Paris; Paris, France; Pathogenesis; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Plague; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Property; Property, LOINC Axis 2; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regeneration; Reproduction spores; Research; Resistance; Resistance to infection; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Spores; Staging; Structure; Subcellular Process; Subcellular structure; Susceptibility; System; System, LOINC Axis 4; Techniques; Testing; Transgenic Organisms; Transplant Recipients; Variant; Variation; WWW; Yersinia pestis disease; bowel; cellular microvillus; children; defense response; disease/disorder; drug/agent; fungus; gene product; host response; imaging; immunoresponse; in vivo; infection resistance; innovate; innovation; innovative; insight; model organism; molecular imaging; novel; pathogen; pathway; public health relevance; regenerate; resistant; roundworm; transgenic; transplant patient; web; world wide web; youngster",A natural host model for microsporidia pathogenesis in the intestine," Project Narrative Microsporidia are responsible for a wide variety of infections, including severe intestinal infections in AIDS patients. However, the molecular mechanisms used by microsporidia to infect host cells, and the host innate immune response to these infections, are poorly understood. This proposal employs a natural nematode host model for microsporidia pathogenesis in the intestine that has potential applicability to understanding the pathogenesis of microsporidian infections in the human intestine.",87528,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,A1,1,386250,
7866923,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI087746-01,,NIAID:474750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"GALLAY, PHILIPPE ANDRE;",6172215;,1R01AI087746,01/15/2010,12/31/2014,"1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; Adverse effects; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; Carcinoma of the Liver Cells; Cells; Chronic Hepatitis C; Chronic type C viral hepatitis; Chronic viral hepatitis C; Ciclosporin; Cirrhosis; Clinical Research; Clinical Study; Complex; CsA; Cyclophilin A; Cyclophilins; Cyclosporin A; Cyclosporin-Binding Proteins; Cyclosporine; Cyclosporine A; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Dependence; Development; Dose; Drug Industry; Drugs; EC 2.7.7.48; EC 2.7.7.6; Esteroproteases; Genetic Alteration; Genetic Change; Genetic defect; Genotype; Goals; HCC; HCV; HCV Chronic Infection; HCV infection; Hepatic Cells; Hepatic Parenchymal Cell; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis C, Chronic; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Human; Human, General; IFN; Immunosuppressants; Immunosuppressive Agents; In Vitro; Industry, Pharmaceutic; Injection of therapeutic agent; Injections; Interferons; Isomerase; Lead; Life Cycle; Life Cycle Stages; Link; Liver Cells; Man (Taxonomy); Man, Modern; Maps; Mediating; Medication; Membrane; Molecular; Molecular Interaction; Mutate; Mutation; NANBH; Nonstructural Protein; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (RNA-directed); Oral; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Pb element; Peptidases; Peptide Hydrolases; Peptidyl-Prolyl cis-trans Isomerase A; Pharmaceutic Preparations; Pharmaceutical Industry; Pharmaceutical Preparations; Phosphorylation; Polymerase; Population; Primary carcinoma of the liver cells; Proteases; Protein Phosphorylation; Protein, Nonstructural; Proteinases; Proteins; Proteolytic Enzymes; RNA Polymerases; RNA Replicase; RNA replication; RNA, Viral; RNA-Dependent RNA Polymerase; RNA-Directed RNA Polymerase; RTCA; Recombinant Proteins; Replication Unit; Replicon; Reporting; Research; Resistance; Ribavirin; Ribovirin; Risk; Role; Sandimmun; SangCya; Series; Source; Specificity; System; System, LOINC Axis 4; Testing; Treatment Side Effects; Tribavirin; Two Hybrid; Variant; Variation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; alternative treatment; analog; base; domain mapping; drug/agent; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; hepatitis non A non B; hepatitis nonA nonB; immunosuppressive; improved; in vitro Assay; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; life course; membrane structure; mutant; neoral; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; public health relevance; research study; resistance mechanism; resistant; resistant mechanism; sandimmune; side effect; social role; success; therapy adverse effect; treatment adverse effect; viral RNA; virus RNA; virus protein; yeast two hybrid system","Cyclophilins, Cyclophilin Inhibitors and Hepatitis C"," PROJECT NARRATIVE An estimated 170 million people worldwide are chronically infected with Hepatitis C virus. 10-20% of these will develop cirrhosis and 1-5% will develop hepatocellular carcinoma. The only currently approved therapy is weekly injection with pegylated interferon and daily oral ribavirin for 6-12 months. The therapy is associated with severe side effects and results in sustained viral clearance in only 50% of all patients. There is therefore a high need to develop new therapies with better efficacy and tolerability. By demonstrating that cyclophilin (Cyp) inhibitors have potent efficacy against HCV, our recent clinical study opens a new line of opportunity to eradicate this prime human threat. The current proposal outlines a comprehensive series of experiments aimed at determining the mechanism of action of Cyp inhibitors that should lead to the identification of new targets for inhibition of HCV. The study of the roles of Cyp - the intracellular targets of the Cyp inhibitors - in HCV replication is novel and should lead to the identification of new host and viral targets for the development of innovative anti-HCV therapies.",87746,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,1,474750,
7862845,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI087764-01,,NIAID:368750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,050220722,US,MO,63103,SAINT LOUIS UNIVERSITY,"TEAGUE, RYAN M;",7265460;,1R01AI087764,02/01/2010,01/31/2015,"ATGN; Address; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Adoptive Transfer; Anti-Viral Response; Antigens; Antiviral Response; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; Blood (Leukemia); CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; Cancerous; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chronic; Clinical; Complex; Defect; Disease; Disorder; Effectiveness; Engineering; Engineerings; Environment; Event; FLR; Failure (biologic function); Gene Expression; Genetic; Goals; Human; Human, General; ITX; Immune response; Immune system; Immunity; Immunization; Immunization, Booster; Immunization, Secondary; Immuno-Chemotherapy; Immunochemotherapy; Immunologic Stimulation; Immunological Stimulation; Immunologically Directed Therapy; Immunostimulation; Immunotherapy; Immunotherapy, Adoptive; Immunotherapy, Cancer, General; Infection; Infusion; Infusion procedures; Intracellular Communication and Signaling; Killings; LYT3; Lead; Leukemias, General; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Molecular; Oncogenic Viruses; Outcome; Patients; Pattern; Pb element; Peripheral; Phenotype; Population; Population Sizes; Position; Positioning Attribute; Proteins; Reagent; Receptor Signaling; Receptors, Antigen, T-Cell; Regulatory Protein; Research; Role; Secondary Immunization; Self Tolerance; Self-Antigens; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; System; System, LOINC Axis 4; T-Cell Proliferation; T-Cell Receptor; T-Cells; T-Lymphocyte; T8 Cells; T8 Lymphocytes; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Translating; Translatings; Tumor Antigens; Tumor Viruses; Tumor-Associated Antigen; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Physiology; Virus; Virus Diseases; Viruses, General; Work; adoptive cell immunotherapy; base; biological signal transduction; body system, allergic/immunologic; booster vaccination; cancer immunotherapy; cell biology; combat; design; designing; disease/disorder; exhaust; exhaustion; experiment; experimental research; experimental study; failure; functional restoration; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; host response; human disease; immune therapy; immunogen; immunoresponse; improved; in vivo; insight; language translation; leukemia; malignancy; neoplasm immunology; neoplasm/cancer; novel therapeutic intervention; organ system, allergic/immunologic; prevent; preventing; public health relevance; receptor expression; regulatory gene product; research study; response; restoration; restore function; restore functionality; restore lost function; self recognition (immune); social role; success; thymus derived lymphocyte; tool; tumor; tumor immunology; tumor-specific antigen; viral infection; virus infection",Exploiting dual-TCR for rescue of CD8 T cell tolerance in adoptive immunotherapy," Project Narrative Adoptive T cell immunotherapy has shown promise as a therapy against cancer and chronic viral infections, but significant obstacles to clinical success remain. One of the primary challenges is maintaining survival and effectiveness of transferred T cells, which are often rendered tolerant or deleted following infusion into patients. We will explore strategies to periodically immunize and rescue adoptively transferred T cell populations to achieve durable therapeutic responses against tumor and virus.",87764,TTT,"Transplantation, Tolerance, and Tumor Immunology",,1,368750,
7866251,R01,AI,1,,02/01/2010,01/31/2011,PA-07-070,1R01AI087785-01,,NIAID:358224;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RIVERSIDE,UNITED STATES,ZOOLOGY,07,627797426,US,CA,92521,UNIVERSITY OF CALIFORNIA RIVERSIDE,"RAY, ANANDASANKAR ;",9514377;,1R01AI087785,02/01/2010,01/31/2015,"Aedes; Aedes (genus); Agonist; Air; Assay; Bancroftian Elephantiasis; Behavior; Behavioral; Bioassay; Biologic Assays; Biological Assay; Blood; CO2; CO2 receptors; Carbon Dioxide; Carbonic Anhydride; Chemicals; Cues; Culex; Culex (Genus); Culicidae; Dengue; Dengue Fever; Detection; Development; Disease; Disorder; Egypt 101 virus; Electrophysiology; Electrophysiology (science); Exhalation; Exhaling; Expiration, Respiratory; Family; Female; Filaria bancrofti; Filaria sanguinis hominis; Filarial Elephantiases; Generations; Goals; Human; Human, General; Insect Repellents; Insecta; Insects; Invertebrates, Insects; Lead; Ligands; Lymphatic Filariasis; Man (Taxonomy); Man, Modern; Masks; Mediating; Methods; Modification; Molecular Genetic; Molecular Genetics; Mosquitoes; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Odors; Olfaction; Olfactions; Parasites; Pb element; Physiologic; Physiological; Play; Programs (PT); Programs [Publication Type]; Receptor Protein; Research; Reticuloendothelial System, Blood; Role; Science of neurophysiology; Skin; Smell; Smell Perception; System; System, LOINC Axis 4; Testing; WNV; West Nile; West Nile virus; Wuchereria bancrofti; Yellow fever virus; breakbone fever; carbon dioxide receptor; chemical informatics; cheminformatics; disease/disorder; feeding; heavy metal Pb; heavy metal lead; improved; in vivo; inhibitor; inhibitor/antagonist; member; neuronal; neurophysiology; novel; programs; public health relevance; receptor; receptor function; response; social role; vector; vector control",Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants,"  Aedes and Culex mosquitoes transmit several diseases including Dengue and lymphatic filariasis, and it is estimated that there are more than a hundred million people worldwide that are infected. Mosquitoes find their human hosts using the sense of smell. The goal of the proposed research is to modify odor-guided host-seeking behavior of Aedes and Culex mosquitoes using cheap and environmentally safe odor molecules that can be used in very small quantities as effective trapping agents, masking agents and repellents. Successful completion of the proposed studies will lead to the development of a new generation of effective and safe insect repellents and lures that act by modifying odor receptor function.",87785,VB,Vector Biology Study Section,,1,358224,
7864409,R01,AI,1,,01/15/2010,12/31/2010,PA-07-070,1R01AI087917-01,,NIAID:437035;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GLENN, JEFFREY S;",1929609;,1R01AI087917,01/15/2010,12/31/2014,"3-D structure; 3-dimensional structure; 3D structure; Amino Acids; Antihistamines; Antiproteases; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Arginine; Arginine, L-Isomer; Atomic Force Microscope; Atomic Force Microscopy; Binding; Binding (Molecular Function); Biochemical; Cells; Characteristics; Chemicals; Chronic; Clinical; Data; Development; Drug resistance; Drugs; Electron Microscopy; Elements; Endopeptidase Inhibitors; Evaluation; Exhibits; Figs; Figs - dietary; Force Microscopy; Future; Gene Products, RNA; Generations; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome; HCV; HCV-Hun NS3 protein; HCV-Hunan NS3 protein; Hepatic Disorder; Hepatitis C virus; Hepatitus C; High Throughput Assay; IFN; Image; In Vitro; Interferons; Internet; Knowledge; L-Arginine; Length; Life Cycle; Life Cycle Stages; Light; Lipids; Liver diseases; Maps; Mediating; Medication; Membrane; Methods; Microfluidic; Microfluidics; Microscopic; Microscopy, Atomic Force; Modification; Molecular; Molecular Interaction; Molecular Virology; Mutation; NS3 protease, hepatitis C virus; NS3 protein, HCV; NS3 protein, hepatitis C virus; New Agents; Patients; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Protease Antagonists; Protease Inhibitor; Protease Inhibitor 5; Proteinase Inhibitors; Proteins; Quartz; Quartz (SiO2); RNA; RNA Binding; RNA, Non-Polyadenylated; Reagent; Resistance; Resolution; Ribonucleic Acid; Role; SERPINB5 gene product; Scanning Force Microscopy; Structure; Technology; Testing; Therapeutic; Time; Toxic effect; Toxicities; Translating; Translatings; VESCL; Vesicle; Viral; Viral Activity; Viral Function; Viral Physiology; Virus; Virus Replication; Viruses, General; WWW; aminoacid; anti-hepatitis C; base; design; designing; drug resistant; drug/agent; gene product; genome mutation; hepatitis C virus NS3 protein; hepatopathy; high throughput screening; imaging; inhibitor; inhibitor/antagonist; language translation; life course; liver disorder; maspin; maspin gene product; member; membrane structure; mutant; novel; p70(NS3); public health relevance; resistance to Drug; resistant; resistant to Drug; small molecule; social role; tertiary amine; three dimensional structure; treatment of viral infectious disease; virus multiplication; web; world wide web",HCV NS4B: Translating molecular virology into novel antiviral therapies," HCV remains an important cause of worldwide liver disease for which current therapies are inadequate. We have discovered two new targets within the HCV NS4B protein and identified small molecule inhibitors of these targets. We propose to further study these compounds' mechanism of action, better understand the structure and function of these compounds' targets within NS4B and the HCV life cycle, and determine these compounds' potential as critical components of future anti-HCV cocktails.",87917,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,1,437035,
7780125,R01,AR,1,,01/15/2010,12/31/2010,PA-07-070,1R01AR055941-01A2,,NIAMS:330804;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SEATTLE,UNITED STATES,PEDIATRICS,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"MILLER, DANIEL G;",1943348;,1R01AR055941,01/15/2010,12/31/2014,"AAV vector; Abscission; Acantholysis Bullosa; Adeno-Associated Viruses; Alleles; Allelomorphs; Alternate Splicing; Alternative Splicing; Anaplastic; Antimorphic mutation; Athymic Nude Mouse; Autograft; Autologous Transplantation; Autotransplant; Back; Biopsy; Birth; Bleb; Blister; Blotting, Southern; Body Tissues; Bulla; Bullous Lesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell Surface Proteins; Cell Transplants; Cells; Cessation of life; Characteristics; Cicatrix; Clinical Trials; Clinical Trials, Unspecified; Clone Cells; Collaborations; Comparative Genome Hybridization; Cutaneous Disorder; DNA; DNA Recombination; DNA blotting; DNA recombination (naturally occurring); DNA, Single-Stranded; Death; Deoxyribonucleic Acid; Dependovirus; Dermatoplasties; Dermatoplasty; Dermatoses; Detection; Disadvantaged; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Epidermolysis Bullosa; Epidermolysis Bullosa Simplex; Epithelium; Excision; Exons; Extirpation; Foundations; Frequencies (time pattern); Frequency; Future; Gene Expression; Gene Targeting; Gene Transcription; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Modified; Gene-Tx; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic Recombination; Genetic Transcription; Genetic defect; Genome; Genome Stability; Genomics; Growth; Hereditary; Human; Human, General; Immune; Immune response; Infection; Inherited; Intervention, Genetic; Intracellular Communication and Signaling; K5 keratin; Karyotype; Keratin; Lead; Life; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Athymic; Mice, Nude; Modeling; Molecular Biology, Gene Therapy; Mosaicism; Mother Cells; Murine; Mus; Mutate; Mutation; Nude Mice; Pain; Painful; Parturition; Patients; Pb element; Phenotype; Population; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Proteins, Cell Surface; RNA Expression; RNA Sequences; RNA Splicing, Alternative; Recombination; Recombination, Genetic; Recurrence; Recurrent; Removal; Reporting; Scars; Sequences, RNA; Signal Transduction; Signal Transduction Systems; Signaling; Single-Stranded DNA; Site; Skin; Skin Diseases; Skin Diseases and Manifestations; Skin Transplantation; Sorting - Cell Movement; Southern Blotting; Stability, Genomic; Stem cells; Stratification; Suppressor Mutations; Surgical Removal; Targetings, Gene; Techniques; Testing; Therapeutic; Therapy, DNA; Tissue Growth; Tissues; Transcript; Transcription; Transcription, Genetic; Transplantation; Transplantation, Autologous; Transplants, Cell; Undifferentiated; Vesication; Virginia; Xenograft Model; adeno associated virus group; adeno-associated viral vector; adeno-associated virus vector; biological signal transduction; cell transduction; cellular transduction; clinical investigation; comparative genomic hybridization; design; designing; disease/disorder; effective therapy; experiment; experimental research; experimental study; expression vector; gene product; gene therapy; genetic therapy; genome mutation; grafting, skin; heavy metal Pb; heavy metal lead; homologous recombination; host response; immunogenic; immunoresponse; in vivo; in vivo Model; karyogram; keratin 5; keratin 5, K5; keratinocyte; medical complication; mutant; ontogeny; prevent; preventing; public health relevance; reconstitute; reconstitution; repository; research study; resection; skin disorder; sorting; transduced cells; transplant; treatment strategy; vector",Keratin Gene Targeting for the Treatment of Epidermolysis Bullosa," Project Narrative Epidermolysis Bullosa Simplex (EBS) is an extremely debilitating disease characterized by recurrent painful skin blisters beginning at birth and continuing throughout life. Medical complications of this blister formation include infection, scarring, and even death. There is currently no effective therapy for preventing these blisters. This proposal describes experiments designed to test gene therapy strategies for the treatment of epidermolysis bullosa simplex.",55941,ZRG1,Special Emphasis Panel,A2,1,330804,
7785910,R01,AR,1,,01/15/2010,11/30/2010,PA-07-070,1R01AR056343-01A2,,NIAMS:356756;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,DAVIS,UNITED STATES,DERMATOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"LIU, FU-TONG ;",1903137;,1R01AR056343,01/15/2010,11/30/2014,"0-11 years old; ATGN; Affect; Affinity; Allergic; Amino Acid Sequence; Animal Lectins; Antigens; Area; Atopic Dermatitis; Basophilic Histiocyte; Basophils, Tissue; Binding; Binding (Molecular Function); Biogenesis; Biological Function; Biological Process; Blood leukocyte; CBP-30; CBP-35; CBP35; Carbohydrate-Binding Protein 35; Carbohydrates; Cell Function; Cell Process; Cell Surface Proteins; Cell Surface Receptors; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Child; Child Youth; Children (0-21); Chronic; Complex; Consensus; Consensus Sequence; ConsensusSequence; Cutaneous Disorder; D-Galactoside-Binding Lectin; Data; Dendritic Cells; Dermatitis, Atopic; Dermatoses; Developed Countries; Developed Nations; Development; Disease; Disorder; Eczema, Atopic; Edodekin Alfa; Epithelial Cells; Epsilon-Binding Protein; Family; Galactose Binding Lectin; Galactosides; Galaptins; Galectin 3; Galectins; Genetically Engineered Mouse; Glycans; Goals; HL-29; Human; Human, Child; Human, General; IL-12; IL12; INFLM; IgE Binding Protein; IgEBP; Immune; In Vitro; Industrialized Countries; Industrialized Nations; Inflammation; Inflammatory; Inflammatory Response; Interleukin-12; L-29 Lectin; L-31; L-34; L30 Lectin; LGALS3; Lectin; Lectins, Animal; Lectins, S-Type; Leukocytes; MHC Receptor; MVB; Mac-2 Antigen; Macrophage-2 Antigen; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Marrow leukocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mice; Modeling; Molecular; Molecular Interaction; Multivesicular Body; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; Origin of Life; Peptide Signal Sequences; Play; Polysaccharides; Population; Prevalence; Process; Production; Protein Structure, Primary; Proteins; Proteins, Cell Surface; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Regulation; Reticuloendothelial System, Leukocytes; Role; Screening procedure; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Skin; Skin Diseases; Skin Diseases and Manifestations; Sorting - Cell Movement; Subcellular Process; T-Cell Receptor; T-Cells; T-Lymphocyte; Testing; Th-1 Cell; Th-2 Cell; Th1 Cells; Th2 Cells; Thymus-Dependent Lymphocytes; Two Hybrid; Type 1 Helper Cell; Type 2 Helper Cell; VESCL; Veiled Cells; Vesicle; White Blood Cells; White Cell; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; allergic airway epithelium inflammation; allergic airway inflammation; allergic dermatitis; allergic eczema; base; beta-D-Galactosyl-Specific Lectin; beta-Galactoside Binding Lectin; carbohydrate receptor; cell type; children; cross-link; crosslink; cytokine; disease/disorder; extracellular; gene product; immunogen; immunological synapse; in vivo; mast cell; mastocyte; member; mouse model; new therapeutics; next generation therapeutics; novel; novel therapeutics; protein bound carbohydrate; protein function; protein sequence; protein signal sequence; public health relevance; receptor downregulation; receptor expression; response; screening; screenings; skin disorder; social role; sorting; thymus derived lymphocyte; white blood cell; white blood corpuscle; yeast two hybrid system; youngster",Galectin-3 in regulation of allergic skin inflammation,"  Atopic dermatitis is a common chronic inflammatory skin disease. The prevalence of this disease has increased by two- to three-fold during the past three decades in industrialized countries, where the current prevalence in children is estimated to be 15-20%. The treatment of this disease continues to be a challenge. Elucidation of the cellular and molecular bases of this disease is important for development of novel therapeutic strategies.  Galectin-3 is a member of a family of proteins that bind carbohydrates, called lectins. The galectin family defined by their binding of ¨-galactosides and sharing of similar amino acid sequences. When galectin-3 is added to various cells, it can bind to cell surface proteins that have attached carbohydrates recognizable by the lectin. However, there is a great deal of evidence that galectin-3 that is present inside the cells regulates various cellular functions through intracellular actions (without the protein being secreted).  We have obtained important information on the functions of galectin-3 by studying genetically engineered mice we generated that lack galectin-3. Most recently, we found that galectin-3 plays an important function in the response of T cells. We found that galectin-3 is clustered inside the cells in the area that is important for the T cell response called the immunological synapse. We also found that galectin-3 has an important function in another cell type called dendritic cells.  We have previously demonstrated that galectin-3 promotes allergic airway inflammation. We now have a significant amount of data supporting the role of this protein in a mouse model of atopic dermatitis. Additional work is required for understanding how galectin-3 regulates these inflammatory processes and for advancing strategies for developing galectin-3-targeting therapies.  In this proposal, we plan to establish the mechanism by which galectin-3 regulates the responses of T cell and dendritic cell, which are both key cell types in the development of allergic skin inflammation associated with atopic dermatitis. We also plan to elucidate the cellular basis for galectin-3's regulatory role in a mouse model of atopic dermatitis.",56343,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",A2,1,356756,
7784808,R01,AR,1,,02/01/2010,01/31/2011,PA-07-070,1R01AR056664-01A1,,NIAMS:400500;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"DURYEA, JEFFREY W;",6201406;,1R01AR056664,02/01/2010,01/31/2013,"3D image; Active Follow-up; Address; Area; Arthritis, Degenerative; Bone Cysts; Bone Marrow; Cartilage; Cartilage, Articular; Cartilagenous Tissue; Clinical; Color; Computer Programs; Computer Software Tools; Computer software; Cyst; Data; Degenerative polyarthritis; Disease Progression; Dropsy; Edema; Enrollment; Evaluation; Hydrops; Image; Image Analyses; Image Analysis; Imagery; Images, 3-D; Incidence; Industry; Knee; Knee Osteoarthritis; Knee joint; Laboratories; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Metric; Modification; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Nuclear Magnetic Resonance Imaging; Organ; Osteoarthritis; Osteoarthritis, Knee; Osteoarthrosis; Pain; Painful; Physiologic pulse; Printing; Process; Process Measure; Public Health; Pulse; ROC Analysis; Reader; Research; Resolution; Reticuloendothelial System, Bone Marrow; Scanning; Science of Statistics; Side; Simple Bone Cyst; Slice; Software; Software Tools; Solitary Bone Cyst; Solitary Cysts; Specific qualifier value; Specified; Statistics; Structure; Structure of articular cartilage; Surface; System; System, LOINC Axis 4; Techniques; Testing; Thick; Thickness; Three-Dimensional Image; Time; Tools, Software; Unicameral Bone Cyst; United States National Institutes of Health; Visualization; Work; Zeugmatography; articular cartilage; base; cohort; computer program/software; degenerative joint disease; develop software; developing computer software; enroll; follow-up; hypertrophic arthritis; image evaluation; image processing; image registration; imaging; improved; morphometry; public health medicine (field); public health relevance; software development; statistics; success; tool",Quantitative MRI analysis method for longitudinal assessment of knee OA, Narrative: This project will address public health concerns by validating an improved technique for evaluating osteoarthritis of the knee. The work will contribute to the public health indirectly by assisting others in developing and evaluating OA therapies.,56664,SBSR,Skeletal Biology Structure and Regeneration Study Section,A1,1,400500,
7789919,R01,AR,1,,02/01/2010,01/31/2011,PA-07-070,1R01AR056678-01A1,,NIAMS:342000;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAINT LOUIS,UNITED STATES,NONE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"CIVITELLI, ROBERTO ;",1888073;,1R01AR056678,02/01/2010,01/31/2015,"21+ years old; Ablation; Adipocytes; Adipose Cell; Adult; Affect; Anabolism; Autoregulation; BMP-2; BMP-2A; BMP2; Binding; Binding (Molecular Function); Bone; Bone Development; Bone Formation; Bone Growth; Bone and Bones; Bones and Bone Tissue; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Proliferation; Chondrocytes; Chondrogenesis; Commit; Complex; Cues; Data; Defect; Dependency; Dependency (Psychology); Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Equilibrium; Extremities; Fat Cells; Fibroblasts; Fracture; Future; Genes; Genetic Alteration; Genetic Change; Genetic defect; Homeostasis; Human, Adult; In Vitro; Inhibition of Cell Proliferation; Intracellular Communication and Signaling; Life; Limb structure; Limbs; Lipocytes; Mammals, Mice; Mature Lipocyte; Mature fat cell; Mediating; Mesenchymal; Mice; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mutation; Negative Control of Cell Proliferation; Negative Regulation of Cell Proliferation; Non-Trunk; Osteoblasts; Osteogenesis; Osteoporosis; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; Proliferating; Recruitment Activity; Regulation; Research; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Development; Skeleton; System; System, LOINC Axis 4; Testing; Therapeutic; Trans-Activation (Genetics); Transactivation; adult animal; adult human (21+); balance; balance function; base; biological signal transduction; biosynthesis; bone; bone cell; bone fracture; bone mass; bone morphogenetic protein 2; cultured cell line; demineralization; emotional dependency; genome mutation; in vivo; in vivo Model; mature animal; mutant; osteoblast differentiation; osteoclastogenesis; osteogenic; overexpression; prevent; preventing; programs; public health relevance; recruit; skeletogenesis; social role",Smad4/B-Catenin Signaling Cross-Talk for Osteoblastogenesis,"  Therapeutic options for stimulating bone formation in subjects with bone demineralization, such as osteoporosis, are limited. This research will study an interaction between two molecules that determine how bone forming cells replicate or differentiate to produce new bone. Results will allow us to better understand how bone forming cells proliferate and function in adult animals, and will disclose new ways to stimulate bone formation that may be used in the future to discover new treatments for people with low bone mass and fractures.",56678,SBSR,Skeletal Biology Structure and Regeneration Study Section,A1,1,342000,
7781904,R01,AR,1,,02/01/2010,12/31/2010,PA-07-070,1R01AR056729-01A2,,NIAMS:393750;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW YORK,UNITED STATES,,14,622146454,US,NY,100214872,HOSPITAL FOR SPECIAL SURGERY,"HU, XIAOYU ;",8702042;,1R01AR056729,02/01/2010,12/31/2014,"Acute; Address; Animal Model; Animal Models and Related Studies; Arthritis; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atrophic Arthritis; Autoimmune; Autoimmune Diseases; Autoimmune Process; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Blood monocyte; Body Tissues; CSBP1; CSBP2; CSPB1; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chronic; Cytokine Gene; DIF; Development; Differentiation Factor, B-Cell; Disease; Disorder; ES01; EXIP; Edodekin Alfa; Elements; Endotoxins; Ensure; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Feedback; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Goals; HES-1; HES1; HPGF; Hepatocyte-Stimulating Factor; Host Defense; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-1; IL-12; IL-23; IL-6; IL1; IL12; IL6 Protein; INFLM; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Inflammation; Inflammatory; Inflammatory Arthritis; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-12; Interleukin-6; Intracellular Communication and Signaling; Killings; Knowledge; Lead; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphocyte-Stimulating Hormone; MAPK14; MAPK14 gene; MGI-2; Macrophage Activation; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Mice; Microbe; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mxi2; Myeloid Differentiation-Inducing Protein; NKSF; Natural Immunity; Natural Killer Cell Stimulatory Factor; Notch Signaling Pathway; Organ; PRKM14; PRKM15; Pathogenesis; Pathway interactions; Pb element; Physiologic; Physiological; Plasmacytoma Growth Factor; Play; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteolysis and Signaling Pathway of Notch; Recruitment Activity; Regulation; Rheumatoid Arthritis; Role; SAPK2A; SLE; SLE - Lupus Erythematosus, Systemic; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Site; Study models; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T Helper Factor; TIL4; TLR2; TLR2 gene; TLR4 receptor; TNF; TNF A; TNF gene; TNFSF2; Targetings, Gene; Testing; Therapeutic Intervention; Tissues; Toll-4 receptor; Toll/Interleukin 1 Receptor-Like 4 Gene; Toxic effect; Toxicities; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Tumor Necrosis Factor Gene; arthritic; atheromatosis; atherosclerotic vascular disease; autoimmune disorder; biological signal transduction; chromatin modification; cultured cell line; cytokine; disease/disorder; disseminated lupus erythematosus; heavy metal Pb; heavy metal lead; host response; immunoresponse; in vivo; insight; interest; interferon beta 2; interleukin-23; intervention therapy; lymphocyte activating factor; macrophage; microbial; model organism; monocyte; notch; notch protein; notch receptors; novel therapeutic intervention; p38; p38 MAPK Gene; p38Alpha; pathway; public health relevance; recruit; response; social role; systemic lupus erythematosis; therapeutic target; toll-like receptor 4",Selective regulation of macrophage activation,"  Macrophages are immune cells that produce inflammatory cytokines that are important in many autoimmune and inflammatory diseases, including rheumatoid arthritis (RA), inflammatory bowel disease and atherosclerosis, and possibly systemic lupus erythematosus (SLE). Cytokines are proven therapeutic targets in human autoimmune diseases, and this application will focus on understanding how the production of these cytokines is regulated. We anticipate that our studies will yield insights that can be exploited for therapeutic interventions to suppress inflammation in autoimmune diseases.",56729,III,Innate Immunity and Inflammation Study Section,A2,1,393750,
7784742,R01,AR,1,,02/01/2010,11/30/2010,PA-07-070,1R01AR056991-01A1,,NIAMS:339461;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"SHAYMAN, JAMES ALAN;",1881108;,1R01AR056991,02/01/2010,11/30/2014,"1(2H)-Phthalazinone, hydrazone; Apoptotic; Apresoline; Apressin; Autoimmune; Autoimmune Diseases; Autoimmune Process; Bacteriophages; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-; Binding; Binding (Molecular Function); Bright Disease; Cell Communication and Signaling; Cell Membrane Lipids; Cell Signaling; Cells; Ceramide (lipids); Ceramides; Chinidin; Choline Glycerophospholipids; Choline Phosphoglycerides; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Clinical; DNA Alteration; DNA mutation; Defect; Digestion; Disease; Disorder; Drugs; EC 3.1.1.4; Eating; Electrostatics; Enzymes; Exhibits; Family; Food Intake; Gene Alteration; Gene Mutation; Genes; Genetic mutation; Glomerulonephritis; Hepatosplenomegaly; Heymann Nephritis; Human; Human, General; Hydralazine; Hydrazinophthalazine; ITX; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; Immunologically Directed Therapy; Immunotherapy; Impairment; Intracellular Communication and Signaling; Kidney Failure; Kidney Insufficiency; Knockout Mice; Laboratories; Lecithin; Lecithinase A2; Lecithinases; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymph node proper; MERTK; MERTK protein, human; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Membrane Lipids; Mer protein, human; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Murine; Mus; NCAM-related tyrosine kinase protein, human; Names; Null Mouse; Nyk protein, human; PLA2; Pathogenesis; Phages; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenocopy; Phenotype; Phosphatides; Phosphatidylcholines; Phospholipase; Phospholipase A2; Phospholipid Degradation; Phospholipid Degradation Pathway; Phospholipids; Procainamide; Procaine Amide; Quinidine; Receptor Protein; Receptor Tyrosine Kinase MerTK; Renal Failure; Renal Insufficiency; Reporting; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Spleen; SLE; SLE - Lupus Erythematosus, Systemic; Secondary to; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Spleen; Stimulus; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Testing; Zymosan; autoimmune disorder; bacterial virus; base; biological signal transduction; c-mer Proto-oncogene Tyrosine Kinase; c-mer proto-oncogene tyrosine kinase, human; disease/disorder; disseminated lupus erythematosus; drug induced lupus; drug/agent; enzyme activity; experiment; experimental research; experimental study; human MERTK protein; immune therapy; insight; lecithinase A; lymph gland; lymph nodes; macrophage; milk fat globule; novel; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; proto-oncogene protein c-mer, human; protooncogene protein c-mer, human; public health relevance; receptor; research study; response; systemic lupus erythematosis; tyrosine kinase of monocytes and epithelial and reproductive tissues protein, human; uptake; wasting",Lysosomal phospholipase A2 in autoimmune disease," Relevance Statement We have discovered and characterized a new lysosomal phospholipase A2. Knockout mice, deficient in the activity of this enzyme, develop a late onset autoimmune phenotype with features similar to systemic lupus erythematosus. Understanding the mechanisms whereby impaired degradation of phospholipids result in the autoimmune phenotype may provide new insights into the pathogenesis of lupus and potential new targets for therapy.",56991,ACTS,"Arthritis, Connective Tissue and Skin Study Section",A1,1,339461,
7768598,R01,AR,1,,04/01/2010,03/31/2011,PA-07-070,1R01AR057886-01,,NIAMS:213014;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NASHVILLE,UNITED STATES,ENGINEERING (ALL TYPES),05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"MCCABE, CLARE ;",8126149;,1R01AR057886,04/01/2010,03/31/2013,"Absorption; Allergic rhinitis; Allergic rhinitis due to allergen; Allergic rhinosinusitis; Asthma; Atopic rhinitis; Behavior; Biological; Bronchial Asthma; Cells; Ceramide (lipids); Ceramides; Cereals; Chemicals; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Esters; Cholesteryl Esters; Cutaneous Disorder; Data; Dependence; Dermal; Dermatoses; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Effectiveness; Environment; Event; Fatty Acids, Nonesterified; Free Fatty Acids; Gel; Goals; Grain; Health; Horny Layer; Human; Human, General; Hydrogen Oxide; Infection; Investigation; Knowledge; Lateral; Lead; Lipids; Literature; Man (Taxonomy); Man, Modern; Measurement; Medication; Membrane; Methods and Techniques; Methods, Other; Microscopy; Modeling; Models, Molecular; Molecular; Molecular Dynamics Simulation; Molecular Models; Molecular Probes; Nature; Nonesterified Fatty Acids; Nucleic Acid Biochemistry, Molecular Modeling; Palmitic Acids; Pathogenesis; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphatides; Phospholipids; Physiology; Play; Position; Positioning Attribute; Process; Process of absorption; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Protocol; Protocols documentation; Reporting; Research; Rest; Rhinitis allergic atopic; Role; Skin; Skin Diseases; Skin Diseases and Manifestations; Staging; Stratum corneum; Structure; Symptoms; System; System, LOINC Axis 4; Systemic disease; Techniques; Testing; Time; Topical agent; Toxicant exposure; Transcutaneous Administration; Transdermal Administration; Transdermal Route of Drug Administration; Transdermal substance administration; Water; Work; absorption; assault; base; body water loss; chemical dehydration; cholesterol sulfate; cholesteryl sulfate; design; designing; disease/disorder; drug/agent; effective therapy; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; heuristics; improved; insight; intervention development; lipid structure; membrane structure; molecular dynamics; molecular modeling; nano meter scale; nano meter sized; nano scale; nanometer scale; nanometer sized; nanoscale; novel; prevent; preventing; public health relevance; research study; self assembly; simulation; skin disorder; social role; therapy development; toxic exposure; transdermal drug delivery; treatment development; treatment strategy",Using Molecular Modeling to Determine Structure and Organization in Skin Lipids," An improved understanding of lipid organization in the stratum corneum, the outermost layer of the skin, would greatly enhance our understanding of the skin barrier and the dermal absorption process. The work proposed will allow molecular-based insight to the compositional dependence of lipid organization and structure, which would clarify the role of abnormal lipid composition in the symptoms of diseased skin, aid development of treatments for restoring barrier function, and provide insights needed for the rational design of transdermal drug delivery systems.",57886,MSFD,Macromolecular Structure and Function D Study Section,,1,213014,
7888741,R01,AT,1,,02/01/2010,01/31/2011,PA-07-282,1R01AT005280-01A1,,NCCAM:716419;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"GOLLUB, RANDY LYANNE (contact);KAPTCHUK, TED ;",1879433 (contact);2497075;,1R01AT005280,02/01/2010,01/31/2015,"21+ years old; Absence of pain sensation; Absence of sensibility to pain; Acupuncture Analgesia; Acupuncture procedure; Adult; Affect; Affective; Age; Aged 65 and Over; Ambien; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Anodynes; Anterior; Anti-Inflammatory Agents, Non-Steroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Antinociceptive Agents; Antinociceptive Drugs; Anxiety; Area; Arthritis, Degenerative; BOLD response; Behavioral; Belief; Bilateral; Biologic Marker; Biological; Biological Markers; Brain; Brain imaging; Brain region; Care Givers; Caregivers; Cell Communication and Signaling; Cell Signaling; Central Lobe; Central Nervous System; Central gray substance of midbrain; Chronic; Chronic Disease; Chronic Illness; Clinical; Clinical Trial Overviews; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Data Pooling; Data Poolings; Degenerative polyarthritis; Disease; Disorder; Dysfunction; Education; Educational aspects; Elderly; Elderly, over 65; Encephalon; Encephalons; Expectancy; Feels no pain; Functional Magnetic Resonance Imaging; Functional disorder; Future; Grant; Gray; Gray unit of radiation dose; Healed; Heterogeneity; Human, Adult; Image; Individual; Insula; Insula of Reil; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Island of Reil; Judgment; Knee; Knee Osteoarthritis; Laboratories; Left; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Measurement; Measures; Medial; Mediating; Mesencephalic Central Gray; Meta-Analyses; Meta-Analysis; Methodology, Research; Methods; Midbrain Central Gray; Middle Temporal Gyrus; Modeling; Molecular Marker; NSAIDs; Needles; Nervous System, Brain; Nervous System, CNS; Neuraxis; No sensitivity to pain; Nociceptive Impulse; Nociceptive Stimulus; Non-Steroidal Anti-Inflammatory Agents; Nonsteroidal Anti-Inflammatory Agents; Nonsteroidal Antiinflammatory Drug; Opioid Analgesics; Osteoarthritis; Osteoarthritis, Knee; Osteoarthrosis; Outcome; PBO; Pain; Pain Disorder; Pain Research; Painful; Patients; Pattern; Perception; Periaqueductal Gray; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiopathology; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Placebo Effect; Placebos; Population; Precentral gyrus; Prefrontal Cortex; Process; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Randomized; Randomized Clinical Trials; Relative; Relative (related person); Relaxation; Reporting; Research; Research Methodology; Research Methods; Role; Sanofi brand of zolpidem tartrate; Sensory; Series; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Signature Molecule; Social support; Stimulus; Stress; Structure of middle temporal gyrus; Structure of superior frontal gyrus; Superior Frontal Convolution; Superior Frontal Gyrus; Symptoms; Test Result; Testing; Thalamic structure; Thalamus; Treatment Efficacy; Treatment outcome; Trials, Randomized Clinical; acupuncture; adult human (21+); advanced age; amygdaloid nuclear complex; analgesia; annulus of the aqueduct; biological signal transduction; biomarker; blood oxygenation level dependent response; brain visualization; chronic disease/disorder; chronic disorder; chronic pain; chronic painful condition; cingulate cortex; clinical investigation; clinical practice; clinical relevance; clinical significance; clinically relevant; clinically significant; cohort; degenerative joint disease; design; designing; disability; disease/disorder; drug mechanism; effective therapy; elders; expectancy effect; expectation; expectation effect; experience; experiment; experimental research; experimental study; fMRI; functional restoration; geriatric; healing; hypertrophic arthritis; imaging; innovate; innovation; innovative; insight; interventional strategy; late life; later life; midbrain central gray substance; neural circuit; neural circuitry; neuroimaging; nocebo; nonsteroidal anti-inflammatory drugs; novel; older adult; older person; pathophysiology; patient expectation; periaqueductal gray matter; placebo response; psycho-physiological; psychologic; psychological; public health relevance; randomisation; randomization; randomly assigned; research study; response; restore function; restore functionality; restore lost function; senior citizen; sham therapy; social role; social support network; standard care; thalamic; therapeutic efficacy; therapeutically effective; treatment response; trial comparing",An fMRI study of expectancy on acupuncture treatment outcomes in knee OA," Project Narrative The results of the proposed experiments will directly inform clinicians who treat patients with osteoarthritis of the knee about how to maximize the benefits of acupuncture treatments. And because the experiments specifically asks the question of what is the relation between a patient's expectation of how a treatment will relieve their pain and the outcome of the treatment, the results will potentially inform care givers about all treatments for osteoarthritis and other chronic pain disorders.",5280,MRS,Musculoskeletal Rehabilitation Sciences Study Section,A1,1,716419,
7887334,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA128800-01A2,,NCI:266301;,2010,NATIONAL CANCER INSTITUTE,,GREENVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,607579018,US,NC,27858,EAST CAROLINA UNIVERSITY,"LEMASSON, ISABELLE MICHELE;",8653052;,1R01CA128800,02/01/2010,12/31/2014,"0-11 years old; 21+ years old; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; ATF-1; ATF-4; ATF1; Acetyltransferase; Activator Protein-1; Address; Adult; Adult T-Cell Leukemia-Lymphoma Virus I; Affect; Affinity; Basic Leucine Zipper; Binding; Binding (Molecular Function); Binding Sites; Biological; Biology; Blood; Blood (Leukemia); Breast Feeding; Breastfeeding; CREB; CREB-2; CREB1; CREB1 gene; Cancers; Cell Nucleus; Child; Child Youth; Children (0-21); Clinical; Coitus; Collection; Combining Site; Complex; Consensus; DNA Binding; DNA Binding Interaction; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Diagnosis; Dimerization; Disease; Disorder; E1A-associated p300 protein; EP300; EP300 gene; Enhancer-Binding Protein AP1; Family; Gene Deregulation; Gene Down-Regulation; Gene Expression; Gene Expression Microarray Analysis; Gene Transcription; Genes; Genetic Transcription; Goals; HTLV-1; HTLV-I; HTLV1; Human Sexual Intercourse; Human T-Lymphotropic Virus, Type I; Human T-lymphotropic virus 1; Human, Adult; Human, Child; In Vitro; Infection; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Leucine Zippers; Leukemia, T-Cell; Leukemias, General; Life; Lymphocytic Leukemia, T-Cell; Malignant Neoplasms; Malignant Tumor; Mediating; Molecular Interaction; Mothers; N-terminal; NH2-terminal; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nucleus; Oncogene Deregulation; Play; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dimerization; Proteins; Proviruses; RNA Expression; Reactive Site; Regulation; Relative; Relative (related person); Repression; Research; Reticuloendothelial System, Blood; Retroviridae; Retroviruses; Role; Sexual Intercourse; T-Cell Leukemia; T-Cell Leukemia Virus I, Human; T-Cell Proliferation; T-Cells; T-Lymphocyte; T-Lymphocytic Leukemia; Testing; Thymus-Dependent Lymphocytes; Transcription; Transcription Factor AP-1; Transcription Regulatory Protein; Transcription Repression; Transcription, Genetic; Transcriptional Regulatory Protein; Transcriptional Repression; Transmission; Viral; Viral Gene Products; Viral Gene Proteins; Viral Latency; Viral Proteins; Virus; Virus Latency; Virus-HTLV-I; Virus-Retrovirus; Viruses, General; activating transcription factor 1; activating transcription factor 4; adult human (21+); bZIP Domain; base; c jun; c-jun Gene; children; dimer; disease/disorder; gene product; gene repression; human T cell lymphoma virus I; human T cell lymphoma virus type I; human T cell lymphotropic virus 1; human T cell lymphotropic virus type 1; human T lymphotropic virus I; human T-cell leukemia virus type 1; in vivo; insight; leukemia; malignancy; member; neoplasm/cancer; neurodegenerative illness; p300; p300 E1A-associated coactivator; p300 protein; p300-CBP coactivator; p300/CBP proteins; prevent; preventing; public health relevance; social role; thymus derived lymphocyte; transcription factor; transmission process; virus protein; youngster",Regulation of HTLV-1 and cellular gene transcription by the viral protein HBZ," PROJECT NARRATIVE  Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with an aggressive leukemia and a neurodegenerative disease. This virus encodes a viral protein, HTLV-1 bZIP factor (HBZ), which is uniquely encoded on the minus strand of the provirus and is not transcribed from the 5' LTR (the normal viral promoter). This proposal investigates how HBZ is involved in regulating viral and cellular transcription by targeting bZIP transcription factors and key coactivators required for viral and cellular transcription.",128800,VIRA,Virology - A Study Section,A2,1,266301,
7888421,R01,CA,1,,03/01/2010,12/31/2010,PA-07-318,1R01CA129491-01A2,,NCI:320588;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LIU, BIN ;",7041694;,1R01CA129491,03/01/2010,12/31/2013,"ATGN; Address; Affinity; Antibodies; Antibody Affinity; Antigen Targeting; Antigenic Determinants; Antigens; Asbestos; Assay; Bacteriophages; Behavior; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biodistribution; Biologic Assays; Biological Assay; Blood Vessels; Body Tissues; CAT Scan, X-Ray; CAT scan; CD146; CT X Ray; CT scan; Cell Surface Antigens; Cell membrane; Cell surface; Cells; Clinic; Clinical Trials Design; Collaborations; Complementary DNA; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Cytoplasmic Membrane; DNA, Complementary; Detection; Development; Diagnosis; Diagnostic; Disease; Disorder; Drug Kinetics; ELISA; EMI scan; Engineering; Engineerings; Enzyme-Linked Immunosorbent Assay; Epitopes; Eukaryote; Eukaryotic Cell; Exhibits; Exposure to; Forecast of outcome; Funding; Future; Goals; Hu-mABs; Human; Human, General; Immunoradiotherapy; Immunotherapy, Cancer, Radioisotope; In Situ; In Vitro; Investigators; Jobs; Lead; Libraries; Life; Ligands; Light; MCAM; MCAM gene; MUC18; Malignant; Malignant - descriptor; Malignant Fibrous Mesothelioma; Malignant Mesothelial Neoplasm; Malignant Mesothelial Tumor; Malignant Neoplasm of the Mesothelium; Malignant Tumor of the Mesothelium; Malignant mesothelioma; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medical Imaging, Single Photon Emission Computed Tomography; Melanoma Adhesive Molecule Gene; Mesothelioma; Mesothelium; Methods; Molecular; Molecular Interaction; NCI; NCI Organization; National Cancer Institute; National Institute for Occupational Safety and Health; National Institute for Occupational Safety and Health (U.S.); Occupations; Patients; Pb element; Phages; Pharmacokinetics; Photometry/Spectrum Analysis, Mass; Photoradiation; Plasma Membrane; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Probability; Professional Postions; Prognosis; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Radioimmunotherapy; Radionuclide Tomography, Single-Photon Emission-Computed; Research Personnel; Researchers; Route; SPECT; SPECT imaging; Sarcomatoid Mesothelioma; Sarcomatous Mesothelioma; Screening procedure; Soluble Mpf/Mesothelin-Related Protein; Sound; Sound - physical agent; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Surface; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Symptoms; Therapeutic; Tissues; Tomodensitometry; Tomography, Emission-Computed, Single-Photon; Tomography, Xray Computed; Tumor Antigens; Tumor Cell; Tumor-Associated Antigen; Work; X-Ray Computed Tomography; Xenograft Model; Yeasts; antigen antibody affinity; antigen binding; assay development; bacterial virus; base; cDNA; catscan; combinatorial; computed axial tomography; computerized axial tomography; computerized tomography; disease subtype; disease/disorder; disorder subtype; eukaryotida; expression cloning; gene product; heavy metal Pb; heavy metal lead; human monoclonal antibodies; immunogen; improved; in vivo Model; megakaryocyte potentiating factor; member; mesothelin; neoplastic cell; new diagnostics; next generation diagnostics; novel; novel diagnostics; outcome forecast; plasmalemma; prognostic; public health relevance; screening; screenings; small molecule; sound; therapeutic development; therapeutic target; tumor; tumor-specific antigen; vascular",Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma," Project narrative:  The objective of this proposal is to establish the molecular identities of a panel of mesothelioma cell surface antigens that are bound by a panel of novel internalizing human single chain antibodies that target both epithelioid and sarcomatoid (a particularly recalcitrant form) mesothelioma. Given that mesothelioma is a major occupation-related illness with no treatment to date, and little is known about mesothelioma cell surface antigens expressed by all subtypes of the disease, identification of mesothelioma antigens targeted by our panel of internalizing antibodies addresses a critical need and is likely to have a significant impact on the development of antibody-based therapeutics and diagnostics against mesothelioma.",129491,CII,Cancer Immunopathology and Immunotherapy Study Section,A2,1,320588,
7782588,R01,CA,1,,01/01/2010,12/31/2010,PA-07-070,1R01CA129771-01A2,,NCI:580656;,2010,NATIONAL CANCER INSTITUTE,,COLUMBUS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"WEWERS, MARY ELLEN;",1865808;,1R01CA129771,01/01/2010,12/31/2014,"2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; 21+ years old; Abstinence; Adult; After Care; After-Treatment; Aftercare; American; Appalachia; Appalachian Region; Application Context; Arm; Behavior; Bladder; COAD; COPD; Cancer of Lung; Cancers; Cervix; Cervix Uteri; Cessation of Treatment; Cessation of life; Cessation of smoking; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Clinical Trials Design; Communities; Control Groups; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cotinine; Counseling; County; Data; Death; Disadvantaged; Disease; Disorder; Economic Burden; Esophagus; Gastrointestinal Tract, Esophagus; Gastrointestinal Tract, Pancreas; Genital System, Female, Cervix; Head and Neck, Larynx; Head and Neck, Pharynx; Health; Health Care Costs; Health Costs; Healthcare Costs; High Prevalence; Human, Adult; IT Systems; Individual; Information Systems; Information Technology Systems; Intervention; Intervention Strategies; Intervention Studies; Interview; Kidney; Laryngeal; Larynx; Logistic Regressions; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Mouth; Malignant neoplasm of lung; Malignant neoplasm of mouth; Measures; Mediating; Methods; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouth Cancer; Neighborhoods; Nurses; Ohio; Oral Cancer; Pancreas; Pancreatic; Participant; Patient Self-Report; Pattern; Personnel, Nursing; Pharyngeal structure; Pharynx; Pharynxs; Phone; Population; Productivity; Public Health; Pulmonary Cancer; Pulmonary Disease, Chronic Obstructive; Pulmonary malignant Neoplasm; Randomized; Regressions, Logistic; Research; Risk; Risk Factors; Sampling; Scotine; Self-Report; Services; Smoke; Smoker; Societal Factors; Systems, Data; Telephone; Throat; Time; Tobacco; Tobacco Cessation; Tobacco Consumption; Tobacco Use Cessation; Tobacco use; Training; Uninsured; United States; Upper arm; Urinary System, Bladder; Urinary System, Kidney; Uterine Cervix; Validation; Vulnerable Populations; Withholding Treatment; adult human (21+); cease smoking; cigarette smoking; contextual factors; disease/disorder; intervention effect; interventional strategy; lung cancer; malignancy; malignant mouth neoplasm; neoplasm/cancer; novel; premature; public health medicine (field); public health relevance; quit line; quitline; randomisation; randomization; randomized trial; randomly assigned; renal; smoke cigarette; smoking cessation; social; success; tobacco abstinence; tobacco exposure; trend; urinary bladder; voice box",Tobacco cessation interventions with Ohio Appalachian smokers," PUBLIC HEALTH RELEVANCE STATEMENT The proposed study examines the efficacy of a scientifically valid tobacco cessation intervention with Ohio Appalachian community residents, a group known to have increased rates of tobacco-attributable diseases. We will also examine social and contextual factors associated with tobacco cessation. Finally, in selected neighborhoods and communities, we will characterize pro- and anti-tobacco features that may influence cessation, using a novel geographical information system to describe patterns of exposure.",129771,CLHP,Community-Level Health Promotion Study Section,A2,1,580656,
7795767,R01,CA,1,,01/01/2010,12/31/2010,PA-08-052,1R01CA133697-01A1,,NCI:420659;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"NEL, ANDRE ELIAS;STODDART, JAMES FRASER;TAMANOI, FUYUHIKO  (contact);ZINK, JEFFREY I;",1863185 (contact);1890438;6527935;8824490;,1R01CA133697,01/01/2010,12/31/2014,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; (S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4'[{..}]6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione; 1,2-Benzo-Pyrones; 1,2-Benzopyrones; 1,2-benzopyrone; 14-Hydroxydaunomycin; 1H-Pyrano(3',4'[{..}]6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI); 20-(S)-camptothecine; 21, 22-secocamptothecin-21-oic acid lactone; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 5,6-benzo-alpha-pyrone; Adriablastin; Adriablastine; Adriacin; Adriamycin PFS; Adriamycin RDS; Adriamycine; Adriblastin; Adriblastina; Adriblastine; Adrimedac; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Apoptosis; Apoptosis Pathway; Asotax; Athymic Nude Mouse; Bristaxol; CAPS; California; Camptothecin; Cancer Drug; Cancer Treatment; Cancer cell line; Cancerous; Capsules; Carcinoma Cell; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell membrane; CellLine; Cells; Chemotherapeutic Agents, Neoplastic Disease; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Coloring Agents; Combination Chemotherapy Regimen; Confocal Microscopy; Constitution; Coumarines; Coumarins; Cristobalite; Cytoplasmic Membrane; Cytotoxic cell; DNA Binding; DNA Binding Agent; DNA Binding Interaction; DOX; DOXO-CELL; Doxolem; Doxorubicin; Doxorubicina; Doxorubin; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Dyes; Environment; Farmiblastina; Folate; Goals; Human; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Injection of therapeutic agent; Injections; Institutes; Investigation; Investigators; Iodide, Propidium; K lymphocyte; Label; Laboratories; Ligands; Light; Liposomal Adriamycin; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Mice; Mice, Athymic; Mice, Nude; Microscopy, Confocal; Molecular Machines; Murine; Mus; NK Cells; Natural Killer Cells; Nude Mice; Operation; Operative Procedures; Operative Surgical Procedures; Paclitaxel; Paclitaxel (Taxol); Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Plasma Membrane; Praxel; Principal Investigator; Propidium Diiodide; Proteins; Pseudorotaxanes; Quimioterapia; Research; Research Personnel; Researchers; Rubex; Sand; Silica; Silicon Dioxide; Site; Solid; Solutions; Stimulus; Structure; Surface; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Tonka Bean Camphor; Tridymite; Tumor-Specific Treatment Agents; Universities; adriamycin; alpha benzopyrone; anticancer agent; anticancer drug; anticancer therapy; aqueous; azobenzene; cancer cell; cancer chemotherapy; cancer therapy; capsule (pharmacologic); chemotherapeutic agent; controlled release; coumarin; cultured cell line; design; designing; drug/agent; gene product; improved; improved functioning; light effects; mouse model; nano; nano machine; nano particle; nano systems; nanomachine; nanoparticle; nanosystems; necrocytosis; new approaches; novel; novel approaches; novel strategies; novel strategy; particle; plasmalemma; public health relevance; response; site targeted delivery; skills; subcutaneous; surgery; targeted delivery; tissue culture; tumor; tumor growth; tumor xenograft; uptake","Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs", Project Narrative Nanoparticles that contain pores controlled by molecular machines will be used to release anticancer drugs under control. The result of the research will be a novel system for cancer chemotherapy that eliminates unwanted effects on non-cancerous cells.  ,133697,NANO,Nanotechnology Study Section,A1,1,420659,
7783495,R01,CA,1,,01/19/2010,12/31/2010,PA-07-070,1R01CA134658-01A2,,NCI:346918;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"SEGARS, WILLIAM P;",7608748;,1R01CA134658,01/19/2010,12/31/2013,"3-D Imaging; 3D imaging; 4-dimensional; Anatomic; Anatomical Sciences; Anatomy; Area; Arts; Body Tissues; Breast; Breast Cancer Treatment; Breast Microcalcification; Cancer of Breast; Cardiac; Characteristics; Complex; Computer Graphics; Computer Programs; Computer Simulation; Computer software; Computerized Models; Data; Data Set; Dataset; Detection; Devices; Diagnosis; Disease; Disorder; Early Diagnosis; Elements; Female; Female breast; Foundations; Four-dimensional; Goals; Health; Human; Human, General; Image; Imaging Device; Imaging Procedures; Imaging Techniques; Imaging Tool; Imaging, Three-Dimensional; Laboratories; Lesion; Literature; MMG; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammogram; Mammography; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Medical Imaging; Medical Imaging, Three Dimensional; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microcalcification; Modality; Modeling; Models, Computer; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Patients; Performance; Physiology; Position; Positioning Attribute; RDST; Reporting; Research; Resolution; Science of Anatomy; Series; Simulate; Simulation, Computer based; Software; Source; Stratification; Surface; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Texture; Three-Dimensional Imaging; Time; Tissues; Universities; Variant; Variation; Work; anatomy; base; clinical practice; clinical relevance; clinically relevant; computational modeling; computational models; computational simulation; computer based models; computer program/software; computerized; computerized modeling; computerized simulation; data modeling; design; designing; digital; disease/disorder; early detection; flexibility; imaging; imaging modality; improved; in silico; male; malignant breast neoplasm; multimodality; public health relevance; radiologist; simulation; tool; virtual simulation; volunteer",3D Digital Breast Phantoms For Multimodality Research, The goal of this work is to create a series of detailed 3D computational breast phantoms with the flexibility to simulate a wide range of anatomical variations (normal and abnormal) and different levels of compression and to incorporate them seamlessly into the 4D NCAT phantom for multimodality breast imaging research.,134658,ZRG1,Special Emphasis Panel,A2,1,346918,
7779580,R01,CA,1,,01/20/2010,12/31/2010,PA-07-070,1R01CA134700-01A2,,NCI:260480;,2010,NATIONAL CANCER INSTITUTE,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"TURESKY, ROBERT J.;",8220333;,1R01CA134700,01/20/2010,12/31/2014,"2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Aberrant crypt foci; Address; Amino Acids; Animal Model; Animal Models and Related Studies; Animals; Aromatic Amines; Arylamines; Aspiration, Respiratory; Assay; Award; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood; Body Tissues; Breathing; C57BL/6N Mouse; CREA; Cancer Causing Agents; Cancers; Carcinogen-DNA Adducts; Carcinogens; Causality; Cessation of smoking; Chemicals; Chinese; Chinese People; Cigarette; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cohort Studies; Cola; Colon; Colon or Rectum; Colorectal; Colorectal Cancer; Concurrent Studies; Creatinine; Cytochrome P-450 Oxidase; Cytochrome P-450 Reductase; Cytochrome P450 Reductase; Cytosol; DNA Adduct Formation; DNA Adduction; DNA Adducts; DNA Damage; DNA Injury; Data; Development; Diet; Dose; Drug Kinetics; EC 1.6.2.4; Educational Mainstreaming; Environment; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epithelial Cells; Etiology; Exhibits; Exposure to; Feces; Ferrihemoprotein P-450 Reductase; Ferrihemoprotein P450 Reductase; Frequencies (time pattern); Frequency; Funding; Future; Gastrointestinal Tract, Feces; Genes; Genetic; Genetically Engineered Mouse; Genus Cola; Goals; Health; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Heterocyclic Amines; Human; Human, General; Individual; Indoles; Inhalation; Inhaling; Inspiration, Respiratory; Intermediary Metabolism; Intestinal; Intestines; Large Intestine; Length of Life; Life; Liver; Liver Cells; Longevity; Lung; METBL; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measurement; Measures; Meat; Metabolic Pathway; Metabolic Processes; Metabolism; Mice; Mission; Mouse Strains; Murine; Mus; NADPH Cytochrome P-450 Oxidoreductase; NADPH Cytochrome P-450 Reductase; NADPH Cytochrome P450 Oxidoreductase; NADPH Cytochrome c Reductase; NADPH-Cytochrome P450 Reductase; NADPH-Ferrihemoprotein Reductase; NADPH-P450 Reductase; NADPH-Specific Cytochrome C Reductase; NADPH[{..}]ferrihemoprotein oxidoreductase; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neoplasms; Oncogens; Oral; Organ; POR; Pathway interactions; PhIP; Pharmacokinetics; Population; Proteins; Public Health; Quinoxalines; Reaction; Relative; Relative (related person); Reporting; Research; Respiratory System, Lung; Reticuloendothelial System, Blood; Risk; Risk Factors; Rodent; Rodentia; Rodentias; Role; Route; Sampling; Smoke; Smoker; Smoking Status; Source; Staging; Stream; Study Subject; Time; Tissues; Tobacco; Tobacco smoke; Tobacco smoking; Toxicology; Tumors; United States; United States National Institutes of Health; University of Minnesota Cancer Center; Urinary System, Urine; Urine; aminoacid; biomarker; body system, hepatic; bowel; cancer risk; carcinogenicity; cease smoking; cigarette smoking; clinical investigation; cooking; cost; design; designing; detoxicate; detoxication; disease causation; disease etiology; disease/disorder etiology; disorder etiology; feeding; gene product; genetic strain; genotoxicity; heterocyclic aromatic amines; in vivo; innovate; innovation; innovative; inspiration; large bowel; life span; lifespan; male; malignancy; model organism; mouse model; neoplasia; neoplasm/cancer; neoplastic growth; novel; organ system, hepatic; pathway; population based; public health medicine (field); public health relevance; pulmonary; quinoline; saturated fat; smoke cigarette; smoking cessation; social role; stool; sugar; urinary","2-Amino-9H-pyrido[2,3-b]indole: a potential colorectal carcinogen formed in tobac"," 2-Amino-9H-pyrido[2,3-b]indole (AaC) is the most abundant of the heterocyclic amine/aromatic amine carcinogens formed in tobacco smoke and may be a causal agent of colorectal cancer in smokers. Mechanistic studies on A¨C genotoxicity in the colon of an animal model and characterization of the metabolic pathways involved in bioactivation and detoxication of A¨C in humans are warranted to clarify the potential role of this genotoxicant in human colorectal cancer.",134700,CE,Cancer Etiology Study Section,A2,1,260480,
7785600,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA134737-01A2,,NCI:429520;,2010,NATIONAL CANCER INSTITUTE,,CHARLOTTESVILLE,UNITED STATES,PATHOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"VANDE POL, SCOTT BRIAN;",1871020;,1R01CA134737,02/01/2010,01/31/2015,"BPV; Benign; Binding; Binding (Molecular Function); Biochemical; Biological Function; Biological Process; Bovine Papillomavirus; Bovine Papular Dermatitis Virus; Bovine Wart Virus; Bovine papillomatosis virus; Cancer Cause; Cancer Etiology; Cancer of Cervix; Cancer of the Uterine Cervix; Cancerous; Cancers; Cells; Cervical Cancer; Cervix Cancer; Cessation of life; Collaborations; Complex; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Viral; Death; Development; Drugs; E6-AP protein, human; E6-associated protein; E6-associated protein, human; Epithelial; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; HPV; HPV 16; HPV-16; HPV16; Human Papillomavirus; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus type 16; Human papillomavirus, type 16; In Vitro; Individual; Infection; Infectious Human Wart Virus; International; L-Leucine; Lead; Length; Leucine; Leucine, L-Isomer; Macromolecular Structure; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant epithelioma; Malignant neoplasm of cervix uteri; Maps; Medication; Methods and Techniques; Methods, Other; Modeling; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Structure; Mutagenesis; Mutate; Mutation; Normal Cell; Oncogene Products; Oncogene Proteins; Oncoproteins; Papilloma Virus, Bovine; Papilloma Virus, Human; Papilloma Viruses; Papillomavirus; Papillomavirus, Bovine; Papillomavirus, Human; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Proteins; Role; Solutions; Structural Protein; Structure; Surface; Techniques; Technology; Therapeutic; UBE3-A protein, human; UBE3A protein, human; Virus Replication; Woman; Work; Zinc; Zn element; aminoacid sequence of peptide; aminoacid sequence of protein; base; cellular targeting; design; designing; drug/agent; experiment; experimental research; experimental study; gene product; genome mutation; hUBE3A; hUBE3A protein, human; heavy metal Pb; heavy metal lead; human UBE3A protein; human papilloma virus 16; in vivo; malignancy; mutant; neoplasm/cancer; peptide sequence; physical property; protein aminoacid sequence; public health relevance; research study; social role; tumor; ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome), human; viral DNA; virus DNA; virus multiplication; wart virus",Papillomavirus E6 Structural Consortium," Papillomaviruses cause numerous cancers, including cervical cancer, because they make a protein called E6 that helps make normal cells into cancerous cells. Understanding the atomic structure of E6 will aid our understanding of how E6 works, and could lead to drugs that act against E6 and thereby against cervical cancer. This application will solve the atomic structure of E6 and perform experiments to show how the E6 structure participates in causing cancer.",134737,VIRA,Virology - A Study Section,A2,1,429520,
7785335,R01,CA,1,,01/11/2010,12/31/2010,PA-07-070,1R01CA134951-01A2,,NCI:326209;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,PHARMACOLOGY,08,001423631,US,MA,02115,NORTHEASTERN UNIVERSITY,"TORCHILIN, VLADIMIR P;",1885268;,1R01CA134951,01/11/2010,12/31/2013,"(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4'[{..}]6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano(3',4'[{..}]6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI); 2-Propen-1-amine; 2-propenoic acid; 20-(S)-camptothecine; 21, 22-secocamptothecin-21-oic acid lactone; 3-Aminopropylene; Adsorption; Alginates; Alkanesulfonates; Alkyl Sulfonates; Alkylsulfonate Compound; Allylamine; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Appearance; Architecture; Area; Asotax; Athymic Nude Mouse; Bioavailability; Biocompatible; Biodistribution; Biologic Availability; Biological Availability; Blood; Blood Circulation; Blood capillaries; Bloodstream; Bovine Serum Albumin; Breast Adenocarcinoma; Bristaxol; CAPS; Caliber; Camptothecin; Cancer Drug; Cancer cell line; Cancers; Capillaries; Capsules; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Membrane Permeability; CellLine; Cells; Cellulose; Charge; Chemotherapeutic Agents, Neoplastic Disease; Chitosan; Chondroitin; Circulation; Clinic; Collaborations; Colloids; Complex; Data; Deposit; Deposition; Development; Dextran Sulfate; Dextran, hydrogen sulfate; Dextrans; Diagnosis, Ultrasound; Diagnostic; Diameter; Dosage Forms; Dose; Drug Carriers; Drug Compounding; Drug Controls; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Kinetics; Drug Preparation; Drug Targeting; Drug Targetings; Drug toxicity; Drug usage; Drugs; Echography; Echotomography; Engineering; Engineering / Architecture; Engineerings; Environment; Ethylenes; Excretory function; Experimental Neoplasms; Experimental Tumor; Formulation; Formulations, Drug; Gelatin; Germinoblastoma; Goals; Hand; Hematopoietic Cell Tumor; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Heparin; Heparinic Acid; Human; Human, General; Hyaluronic Acid; Hydrogen Oxide; Hydrophobicity; IV drip; Imines; In Vitro; Individual; Intravenous Drip; Intravenous Infusion; Investigators; L-Lysine, homopolymer; Laboratories; Length of Life; Ligands; Liposomal; Liposomes; Location; Longevity; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Macrogols; Malignant Cell; Malignant Hematopoietic Neoplasm; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary adenocarcinoma; Man (Taxonomy); Man, Modern; Mediating; Medical Imaging, Ultrasound; Medication; Metabolic; Methods and Techniques; Methods, Other; Mice; Mice, Athymic; Mice, Nude; Micelles; Microcapsules drug delivery system; Mind; Moab, Clinical Treatment; Monitor; Monoclonal Antibodies; Murine; Mus; Na element; Neoplasms, Experimental; Nude Mice; PEG; Paclitaxel; Paclitaxel (Taxol); Participant; Penetration; Peptides; Permeability; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Physiologic Availability; Poliglusam; Polyanhydroglucuronic Acid; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polylysine; Polymers; Polyoxyethylenes; Praxel; Preparation; Process; Property; Property, LOINC Axis 2; Protamine Sulfate; Protocol; Protocols documentation; Public Health; Reporter; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticulolymphosarcoma; Sarcoma, Germinoblastic; Scheme; Serum Albumin, Bovine; Sodium; Solid; Solubility; Solutions; Sonication; Surface; Suspension substance; Suspensions; System; System, LOINC Axis 4; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Techniques; Technology; Testing; Therapeutic; Therapeutic Effect; Thick; Thickness; Time; Treatment Efficacy; Tumor-Specific Treatment Agents; Ultrasonic; Ultrasonic Imaging; Ultrasonics; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; Visit; Water; Work; acrylic acid; alpha-Cellulose; anticancer agent; anticancer drug; aqueous; base; bioavailability of drug; biocompatible polymer; blood cancer; cancer cell; capsule (pharmacologic); colloidal nano particle; colloidal nanoparticle; controlled release; cultured cell line; density; design; designing; dextran; diagnostic ultrasound; drip infusion; drug candidate; drug development; drug efficacy; drug use; drug/agent; excretion; experiment; experimental research; experimental study; improved; in vivo; innovate; innovation; innovative; interest; intravenous administration; life span; lifespan; malignancy; meetings; melanoma; membrane permeability; microcapsule; nano; nano assembly; nano carrier; nano coating; nano meter; nano particle; nano particulate; nano shell; nanoassembly; nanocarrier; nanocoating; nanocolloid; nanometer; nanoparticle; nanoparticulate; nanoshell; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; particle; polyallylamine; polyanion; polycation; prevent; preventing; public health medicine (field); public health relevance; research study; scale up; skills; sonogram; sonography; sound measurement; subcutaneous; sulfonate; suspension; therapeutic efficacy; therapeutically effective; tumor; ultrasound; ultrasound imaging; ultrasound scanning; uptake; vein infusion",Layer-by-layer nanocarriers for highly efficient solubilization of insoluble drug,"  We plan to obtain new dosage forms of poorly soluble drugs suitable for parenteral administration by applying the layer-by-layer (LbL) technology by assembling polyelectrolyte multilayer shells on various particles through the process of an alternate adsorption of oppositely charged polyelectrolytes. This will result in stable aqueous colloids of poorly soluble drugs with high stability, controllable release rate, and very high content (up to 90% wt) of the active drug. By varying the charge density on polymers and/or the number of coating cycles, particles with a controlled surface charge and different composition of the coat can be prepared to control drug release rate. The use of a reactive polymer to form the ""outer"" surface layer will allow for the attachment of specific ligands or reporter groups and other moieties of interest to drug nanoparticles. The approach will be applied to several poorly soluble anticancer drugs, and the nanocolloids obtained will be additionally modified by various ligands to make them long-circulating, targeted, and capable of intracellular penetration.",134951,GDD,Gene and Drug Delivery Systems Study Section,A2,1,326209,
7784918,R01,CA,1,,01/18/2010,12/31/2010,PA-07-070,1R01CA135101-01A2,,NCI:615763;,2010,NATIONAL CANCER INSTITUTE,,TORONTO,CANADA,,,208469486,CA,ON,M5G 2M9,UNIVERSITY HEALTH NETWORK,"BOYD, NORMAN F (contact);ROMMENS, JOHANNA M;",1971830 (contact);2423577;,1R01CA135101,01/18/2010,12/31/2014,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 18 year old; 19 year old; Age; Age Group Unspecified; Androst-4-en-17beta-ol-3-one; Area; Blood; Blood Serum; Body Tissues; Breast; Breast Cancer Prevention; Breast Tissue; Cancer Causing Agents; Cancer of Breast; Carcinogens; Change of Life, Female; Chemotherapy-Hormones/Steroids; Computer Assisted; Contraceptives, Oral; DNA; Data; Delta4-androsten-17beta-ol-3-one; Deoxyribonucleic Acid; Endocrine Gland Secretion; Environmental Exposure; Epidemiology; Esocidae; Event; GFAC; GHN; GWAS; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Variation; Genome; Genotype; Gestation; Goals; Gonadal Steroid Hormones; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Hormone; Growth Hormone 1; Growth Substances; Growth and Development; Growth and Development function; Height; Hereditary; Heritable Quantitative Trait; Hormonal; Hormones; Hydrogen Oxide; Image; Incidence; Inherited; Knowledge; Left; Life; Luteal Phase; MMG; MR Imaging; MR Tomography; MRI; MTGN; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Tumorigenesis; Mammogram; Mammographic Density; Mammography; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Menopause; Menstrual Cycle, Luteal Phase; Menstrual Cycle, Secretory Phase; Menstrual Secretory Phase; Mitogens; Modeling; Mothers; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Oncogens; Oral Contraceptives; Output; Pike; Pike fish; Pituitary Growth Hormone; Postovulatory Phase; Pre-Menopause; Pre-menopausal Period; Predisposition; Pregnancy; Premenopausal; Premenopausal Period; Premenopause; Quantitative Trait, Heritable; Recruitment Activity; Red Cross; Research; Reticuloendothelial System, Blood; Risk; Risk Factors; STH; Sampling; Serum; Sex Hormone-Binding Globulin; Sex Hormones; Sex Steroid Hormones; Sex Steroid-Binding Protein; Slice; Solid; Somatotropin; Susceptibility; Testosterone; Testosterone-Estradiol Binding Globulin; Therapeutic Hormone; Therapeutic Testosterone; Thick; Thickness; Tissues; Trans-Testosterone; Variant; Variation; Variation (Genetics); Water; Weight; Woman; Work; Zeugmatography; age group; aged; allelic variant; birth control pill; cancer risk; computer aided; density; eighteen year old; genetic variant; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; girls; gonadal steroids; hGHN; imaging; malignant breast neoplasm; mammary cancer prevention; mammary tumor prevention; menopausal; mid life; mid-life; middle age; middle aged; midlife; nineteen year old; pre-menopausal; prevent; preventing; public health relevance; recruit; sex steroid; somatotropic hormone; whole genome association studies; whole genome association study",Determinants of breast tissue composition in young women," Research & Related Other Project Information 7. Project Narrative We propose to recruit young women, and their mothers, to add to those already examined, to provide a sample large enough for studies of genes associated with variations in breast tissue composition, and to provide data to confirm findings from previous work concerned with hormones and breast tissue composition. The proposed study will examine the relationship between genotype and the phenotypic features of breast tissue. The work completed to date has shown the feasibility of recruiting the number of young women required to achieve these aims. To the best of our knowledge this is the first extensive study of breast tissue in young women, when susceptibility to carcinogenic events is greatest, and variation in breast tissue composition is also greatest. Further, pregnancy, menopause, and other factors associated with ageing have not yet influenced breast tissue composition. For these reasons it may be easier at early ages to detect genetic effects, as well as the effects of environmental exposures unique to early life.",135101,EPIC,Epidemiology of Cancer Study Section,A2,1,615763,
7780106,R01,CA,1,,01/16/2010,12/31/2010,PAR-07-259,1R01CA135133-01A2,,NCI:714853;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"KRISTAL, ALAN R.;",1921132;,1R01CA135133,01/16/2010,12/31/2013,"Address; Beverages; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Chronic Disease; Chronic Illness; Clinical; Code; Coding System; Collection; Computer Assisted; Computer Programs; Computer Systems Development; Computer software; Computers, Handheld; Data; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Development, Computer Systems; Devices; Diet; Diet Records; Dietary Assessment; Dietary Component; Dietary Records; Dietary intake; Dimensions; Eating; Electromagnetic, Laser; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Evaluation; Evaluation Studies; Food; Food Diaries; Food Intake; Goals; Hand; Hand-Held Computer; Handheld Computers; Health; Home; Home environment; Human; Human, General; IT Systems; Image; Information Systems; Information Technology Systems; Institution; Intake; Investigators; Knowledge; Laboratories; Lasers; Man (Taxonomy); Man, Modern; Measurement; Measures; Methods; Minnesota; Nutrient; Nutrition; Nutrition Research; Nutritional Science; Nutritional Study; Pain; Painful; Paper; Participant; Patient Self-Report; Physical activity; Pilot Projects; Preparation; Procedures; Productivity; Protocol; Protocols documentation; Radiation, Laser; Real-Time Systems; Recommendation; Records; Reporting; Research; Research Personnel; Researchers; Restaurants; Science of nutrition; Scientist; Self-Report; Senior Scientist; Simulate; Software; Sound; Sound - physical agent; Surface; System; System, LOINC Axis 4; Systems Development; Systems, Data; Systems, Real-Time; TXT; Technology; Text; Time; Translating; Translatings; Universities; Voice; Weight; Work; base; chronic disease/disorder; chronic disorder; clinical data repository; clinical data warehouse; computer aided; computer program/software; computerized data processing; cost; data processing; data repository; electronic data; experience; food consumption; imaging; improved; innovate; innovation; innovative; language translation; literacy; miniaturize; new approaches; new technology; novel approaches; novel strategies; novel strategy; nutrition; nutritional epidemiology; optic imaging; optical imaging; pilot study; prototype; public health relevance; relational database; sensor; signal processing; sound; statistics/biometry; systems research; tool; validation studies; volunteer",Integrated sensor technology for real-time recording of food intake," Project Narrative Accurate assessment of diet is key to research on the relationships between diet and health, and much of the controversy regarding diet and chronic disease may be due to the use of poor dietary assessment methods. This proposal develops and evaluates a new approach to dietary assessment, based on a small hand-held computer that records pictures and descriptions of foods as they are eaten. If successful, this new approach to dietary assessment could facilitate our ability to make scientifically sound recommendations for healthful diets.",135133,ZRG1,Special Emphasis Panel,A2,1,714853,
7799641,R01,CA,1,,01/01/2010,12/31/2010,PA-07-070,1R01CA135288-01A1,,NCI:610077;,2010,NATIONAL CANCER INSTITUTE,,MIAMI,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"HU, JENNIFER J;",1971843;,1R01CA135288,01/01/2010,12/31/2014,"Active Follow-up; Acute; Adjuvant Radiotherapy; Adverse Late Effects; Adverse effects; Adverse reactions; African American; Afro American; Afroamerican; American; Amino Acid Sequence; Amino Acids; Angiogenesis Pathway; Apoptosis; Apoptosis Pathway; Assay; Benefits and Risks; Bioassay; Biologic Assays; Biological Assay; Black Populations; Black or African American; Breast; Cancer Cause; Cancer Etiology; Cancer Patient; Cancer Radiotherapy; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Division Cycle; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cellular Migration; Cessation of life; Clinical; Clinical Treatment; Comet Assay; Cosmetics; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Data; Death; Development; Developmental Process; Disease; Disorder; Dropsy; Edema; Electromagnetic Radiation, Ionizing; Epidemiologist; Ethnic group; Evaluation; Follow-Up Studies; Followup Studies; Forecast of outcome; Funding; Gel Electrophoresis, Single-Cell; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Models; Genetic Variation; Genetic analyses; Genetic defect; Genomics; Goals; Hispanic Populations; Hispanics; Hispanics or Latinos; Hydrops; IMRT; INFLM; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Inflammation; Intensity Modulated RT; Intensity Modulated Radiation Therapy; Intensity-Modulated Radiotherapy; Interdisciplinary Research; Interdisciplinary Study; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Ionizing radiation; Knowledge; Late Effects; Latino Population; Lead; Learning; Local Excision Mastectomy; Logit Models; Lumpectomy; Lumpectomy of breast; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Minority; Modeling; Models, Genetic; Models, Logit; Molecular; Molecular Biology, Protein Sequencing; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Multidisciplinary Collaboration; Multidisciplinary Research; Mutation; Non-Hispanic; Normal Tissue; Normal tissue morphology; Not Hispanic or Latino; Oncologist; Outcome; Pain; Painful; Pathway interactions; Patients; Pb element; Peptide Sequence Determination; Phenotype; Phosphorylation; Polymorphism, Single Base; Population; Population Study; Position; Positioning Attribute; Post-Operative; Postoperative; Postoperative Period; Prognosis; Progression-Free Survivals; Protein Phosphorylation; Protein Sequencing; Protein Structure, Primary; QOL; Quality of life; Radiation Oncologist; Radiation Sensitivity; Radiation Tolerance; Radiation therapy; Radiation-Ionizing Total; Radiosensitivity; Radiotherapeutics; Radiotherapy; Radiotherapy, Adjuvant; Reaction; Recruitment Activity; Recurrence; Recurrent; Research; Resection Mastectomy, Limited; Resistance; SNP; SNPs; Sampling; Second Cancer; Second Primary Cancers; Secondary Malignancy; Secondary Malignancy (After Treatment of Primary Cancer); Secondary Malignant Neoplasm; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Skin; Spanish Origin; Staging; Study, Interdisciplinary; Surgeon; Survivals, Progression-Free; Target Populations; Testing; Treatment Side Effects; Trees; Underserved Population; Unscheduled DNA Synthesis; VEGF, Hypoxia, and Angiogenesis; Variation (Genetics); Woman; Work; allelic variant; aminoacid; biological signal transduction; biomarker; black American; breast lumpectomy; cancer diagnosis; cancer disparity; cancer health disparity; cancer risk; cell motility; cohort; cosmetic product; data mining; datamining; design; designing; disease/disorder; dosimetry; effective intervention; experience; follow-up; functional genomics; gene interaction; genetic analysis; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; high risk; high throughput technology; hispanic community; improved; indexing; interventional strategy; irradiation; malignancy; malignant breast neoplasm; medically disadvantaged; medically disadvantaged population; medically underserved group; medically underserved population; neoplasm/cancer; outcome forecast; partial mastectomy; pathway; protein sequence; public health relevance; racial and ethnic; racial/ethnic; recruit; resistant; response; secondary cancer; side effect; standard care; therapy adverse effect; tool; treatment adverse effect; treatment strategy; trial regimen; trial treatment; tumor; under served population; underserved people",Impact of Genomics on Disparities in Breast Cancer Radiosensitivity," PROJECT NARRATIVE  Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in American women. The long-term goal of this study is to improve quality of life, clinical outcome, and breast cancer disparities. The proposed research will use a genome-wide approach to develop and validate genomic prediction models for radiotherapy-induced early and late side effects as well as local-regional recurrence in three racial/ethnic populations. The outcome of the proposed research will advance our scientific knowledge in the accurate assessment of prognosis and response to therapy in cancer patients, which is crucial to controlling the suffering and death due to breast cancer.",135288,RTB,Radiation Therapeutics and Biology Study Section,A1,1,610077,
7781653,R01,CA,1,,01/01/2010,12/31/2010,PA-07-070,1R01CA136799-01A1,,NCI:315400;,2010,NATIONAL CANCER INSTITUTE,,MILWAUKEE,UNITED STATES,PHARMACOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"WILLIAMS, CAROL LUCILLE;",1871384;,1R01CA136799,01/01/2010,12/31/2014,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; Affect; Agar; Assay; Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; C-terminal; Cancer of Lung; Cancers; Carcinoma Cell; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; CellLine; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Cytoplasmic Membrane; Development; Doxycycline; Endoplasmic Reticulum; Epithelial Cells; Ergastoplasm; Family; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GTP GDP exchange factor; GTP Phosphohydrolases; GTPases; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanine Nucleotides; Guanosine Phosphates; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Human; Human, General; Image; In Vitro; Intracellular Communication and Signaling; Laboratories; Lead; Life; Lung; Lung Neoplasms; Lung Parenchyma; Lung Tissue; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measures; Messenger RNA; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Names; Neoplasm Metastasis; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Oncogenesis; Pathway interactions; Patients; Pb element; Photometry/Spectrum Analysis, Mass; Plasma Membrane; Process; Proliferating; Proteins; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; RNA Splicing; RNA, Messenger; RNA, Small Interfering; Recombinant Proteins; Regulation; Reporting; Research; Respiratory System, Lung; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Small Interfering RNA; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Structure of parenchyma of lung; Subcellular Process; Testing; Therapeutic; Time; Tumor Cell Migration; Tumor of the Lung; Variant; Variation; Vibramycin; alpha-6-Deoxyoxytetracycline; base; biological signal transduction; cancer cell; cancer metastasis; cultured cell line; design; designing; exchange factor; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; imaging; in vivo; lung cancer; mRNA; malignancy; malignant phenotype; migration; mutant; neoplasm/cancer; new approaches; nonsmall cell lung cancer; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; pathway; plasmalemma; prenylation; public health relevance; pulmonary; research study; rho; siRNA; tumor; tumorigenesis",Regulation of Ras and Rho Family GTPases in Lung Cancer," Lung cancer cells make a group of proteins called ""small GTPases"". When these small GTPases are activated in lung cancer cells, they induce the lung cancer cells to proliferate and migrate, which promotes tumorigenesis and metastasis. Our laboratory is investigating how these small GTPases are activated in lung cancer, because this information will help us design new ways to stop the activation of small GTPases, and thereby stop lung cancer tumorigenesis and metastasis. We found that a protein called SmgGDS activates small GTPases in lung cancer cells and is made in high amounts in lung tumors from patients. Our proposed research will define how SmgGDS activates different small GTPases in lung cancer. This research may discover how small GTPases are activated in lung cancer and thus may identify new approaches to stop these proteins from promoting lung cancer tumorigenesis and metastasis.",136799,TCB,Tumor Cell Biology Study Section,A1,1,315400,
7779660,R01,CA,1,,01/01/2010,12/31/2010,PA-07-021,1R01CA138410-01A1,,NCI:305497;,2010,NATIONAL CANCER INSTITUTE,,LOUISVILLE,UNITED STATES,BIOCHEMISTRY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"KLINGE, CAROLYN M.;",1892073;,1R01CA138410,01/01/2010,12/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 3' Flanking Region; 3' Flanking Sequence; 3' Untranslated Regions; 3'UTR; 4-Hydroxy-Tamoxifen; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; Active Follow-up; Affect; Androstenedione Aromatase Inhibitor; Anti-Estrogens; Antiestrogens; Aquadiol; Aromatase Inhibitors; Assay; B-Cell CLL/Lymphoma 2 Gene; BCL2; BCL2 gene; BZS; Binding; Binding (Molecular Function); Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Blood Vessels; Blotting, Western; Breast; Breast Cancer Cell; Breast Neoplasms; Breast Tumors; Cancer Patient; Cancer Staging; Cancer Treatment; Cancer cell line; Cancer of Breast; Cancers; Cells; Clinical; Clinical Markers; Cloning; Computer Simulation; Computerized Models; Data; Development; Diagnostic; Diagnostic Neoplasm Staging; Dimenformon; Diogyn; Diogynets; Down-Regulation; Down-Regulation (Physiology); Downregulation; ERalpha; Endocrine; Endocrine Therapy; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol Receptor alpha; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptor alpha; Estrogen Receptors; Estrogen Synthase Inhibitor; Estrogen Synthetase Inhibitor; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exploratory/Developmental Grant; Forecast of outcome; Functional RNA; Gene Expression; Gene Products, RNA; Gene Targeting; Genes; Genes, bcl-2; Genome, Human; Goals; Hormonal Therapy; Human; Human Breast Cancer Cell; Human Genome; Human, General; ICI 182,780; ICI 182780; Immunologic, Luciferase; In Vitro; Individual; Lead; Luciferases; Luciferases, Renilla; Luciferases, Sea Pansy; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MHAM; MMAC1; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Messenger RNA; Micro RNA; MicroRNAs; Models, Computer; Molecular Interaction; Monitor; Neoplasm Staging; Non-Coding; Non-Coding RNA; Ovocyclin; Ovocylin; PTEN; PTEN gene; PTEN1; Patients; Pattern; Pb element; Phosphatase and Tensin Homolog; Plant Embryos; Positive Lymph Node; Prevention; Progesterone Receptors; Prognosis; Progynon; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; R21 Mechanism; R21 Program; RNA; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Small Interfering; RT-PCR; RTPCR; Receptors, Progesterone; Receptors, Progestin; Regulation; Renilla Luciferases; Reporter; Reporting; Repression; Research; Resistance; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; SERMs; Sampling; Seeds; Selective Estrogen Receptor Modulators; Simulation, Computer based; Site; Small Interfering RNA; Stability, mRNA; T-Stage; T47D; TAM; Tamoxifen; Targetings, Gene; Testing; Therapeutic; Therapeutic Estradiol; Therapeutic Estrogen; Time; Transcript; Transfection; Translation Process; Translations; Tumor Staging; Tumor stage; UTRs; Untranslated Regions; Western Blotting; Western Blottings; Western Immunoblotting; Zygotes, Plant; anticancer therapy; antiestrogen; antiestrogenic; biomarker; cancer therapy; ced9 homolog; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; estrogen inhibitor; experiment; experimental research; experimental study; expression vector; follow-up; gene product; heavy metal Pb; heavy metal lead; hormone therapy; human disease; in silico; in vivo; inhibitor; inhibitor/antagonist; insight; mRNA; mRNA Stability; malignancy; malignant breast neoplasm; mammary tumor; miRNA; migration; neoplasm/cancer; node-positive; non-genomic; nongenomic; novel; outcome forecast; overexpression; para-hydroxytamoxifen; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; progesterone receptor; protein blotting; public health relevance; research study; resistant; response; reverse transcriptase PCR; seed; siRNA; social role; tamoxifen metabolite B; treatment planning; tumor; tumor xenograft; vascular; virtual simulation",Regulation of miRNA in breast cancer," Aromatase inhibitor therapy is not useful for all ER¨ positive breast cancer patients and the selective estrogen receptor modulator tamoxifen (TAM) remains the most widely used endocrine therapy for the treatment and prevention of estrogen receptor alpha (ER¨) positive breast cancer. However, ~ 40% of initially TAM-sensitive tumors become endocrine/TAM-resistant. The mechanism behind such acquired TAM/endocrine resistance is unknown. The overall goal of the proposed research is to determine the identity and gene targets of miRNAs that may provide novel biomarkers and new insights into the mechanisms by which breast tumors gain endocrine/TAM-resistance and become invasive and metastatic.",138410,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,A1,1,305497,
7779594,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA138535-01A1,,NCI:368525;,2010,NATIONAL CANCER INSTITUTE,,BIRMINGHAM,UNITED STATES,PATHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"SANDERSON, RALPH D;",7752183;,1R01CA138535,02/01/2010,12/31/2014,"3-D structure; 3-dimensional structure; 3D structure; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Active Sites; Adverse effects; Affinity; Affinity Chromatography; Animal Model; Animal Models and Related Studies; Anticoagulant Agents; Anticoagulant Drugs; Anticoagulants; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biology; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; Cancer Treatment; Cancers; Carbohydrate Chemistry; Characteristics; Chemicals; Chromatography, Affinity; Cleaved cell; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coagulants; Crystallization; Development; Disease; Disorder; Docking; Dose; Drug Design; Drug Kinetics; Drugs; Endoglycosidases; Enzymatic Biochemistry; Enzymes; Enzymology; Exhibits; Forecast of outcome; GFAC; Gelatinase B; Generalized Growth; Generations; Glycols; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HPSE; HPSE Protein; Heparan Sulfate; Heparanase-1; Heparin; Heparinic Acid; Heparitin Sulfate; Human; Human, General; In Vitro; Institutes; Knockout Mice; Knowledge; Length; Link; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-9; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice, Knock-out; Mice, Knockout; Models, Molecular; Modification; Molecular Interaction; Molecular Models; Multiple Myeloma; Myeloma, Plasma-Cell; Neoplasm Metastasis; Normal Tissue; Normal tissue morphology; Nucleic Acid Biochemistry, Molecular Modeling; Null Mouse; Ohio; Oligosaccharides; Osteolysis; Osteolytic; Pathology; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Pharmacology; Phenotype; Play; Prognosis; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Relative; Relative (related person); Research; Research Institute; Reticuloendothelial System, Bone Marrow; Role; Scheme; Secondary Neoplasm; Secondary Tumor; Senior Scientist; Sites, Active; Spectrometry; Spinal Column; Spine; Structure; Structure-Activity Relationship; Testing; Therapeutic Studies; Therapy Research; Tissue Growth; Translations; Treatment Side Effects; Tumor Cell Migration; Type V Collagenase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uronic Acids; VEGFs; Vascular Endothelial Growth Factors; Vegf; Vertebral column; Work; affinity purification; angiogenesis; antibody inhibitor; anticancer therapy; backbone; base; blood thinner; bone; cancer cell; cancer metastasis; cancer therapy; cancer type; chemical structure function; cleaved; clinical investigation; density; design; designing; disease/disorder; drug candidate; drug development; drug/agent; enzyme activity; experiment; experimental research; experimental study; flexibility; gene product; heparan sulphate endoglycosidase; heparanase; in vitro activity; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; malignancy; model organism; molecular modeling; myeloma; myelomatosis; neoplasm/cancer; new therapeutics; next generation therapeutics; novel; novel therapeutic intervention; novel therapeutics; ontogeny; outcome forecast; preclinical study; public health relevance; research study; side effect; social role; structure function relationship; success; sulfation; therapy adverse effect; three dimensional structure; thrombopoiesis inhibitor; tool; treatment adverse effect; tumor; tumor growth",Novel Heparanase Inhibitors for Cancer Therapy, Project Narrative Heparanase is a protein made by cancer cells that plays a major role in helping them grow and spread throughout the body. This project is designed to develop new drugs that will block the function of heparanase and thereby block tumor growth and metastasis.,138535,DMP,Drug Discovery and Molecular Pharmacology Study Section,A1,1,368525,
7889862,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA138882-01A1,,NCI:301604;,2010,NATIONAL CANCER INSTITUTE,,CHAMPAIGN,UNITED STATES,ENGINEERING (ALL TYPES),15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"BHARGAVA, ROHIT ;",8464421;,1R01CA138882,02/01/2010,12/31/2014,"Address; Age; Aging; Algorithms; Analysis, Data; Animal Model; Animal Models and Related Studies; Au element; Automation; Biochemical; Biology; Biopsy; Body Tissues; Cancer of Prostate; Cancers; Care, Health; Cataloging; Catalogs; Cessation of life; Characteristics; Chemicals; Clinical; Clinical Data; Clinical Research; Clinical Study; Collaborations; Coloring Agents; Computers; Data Analyses; Death; Decision Aid; Decision Aids; Diagnosis; Disease; Disorder; Drugs; Dyes; Economics; Engineering; Engineerings; Epidemic; Epithelial Cells; Expenditure; Family; Fourier Transform; Genital System, Male, Prostate; Gleason Grade; Gleason Grade for Prostate Cancer; Gleason Score; Gleason Score for Prostate Cancer; Gleason Sum; Gleason-SC; Goals; Gold; Healthcare; Histologic; Histologically; Histology; Histopathology; Human; Human Prostate; Human Prostate Gland; Human, General; Image; Imaging technology; Incidence; Indolent; Instrumentation, Other; Knowledge; Label; Laboratories; Lead; Lesion; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Manuals; Measurement; Measures; Medication; Methods; Modeling; Molecular; Morphology; Nomograms; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pathologic; Pathologist; Pathology; Patients; Pattern; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; QOL; Quality of life; Reagent; Research; Research Resources; Resolution; Resources; Risk; Risk Factors; Route; Sampling; Scientist; Senescence; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Stains, Tissue; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Technology; Time; Tissue Stains; Tissues; Training; Transform, Fourier; Translating; Translatings; Triage; Work Load; Workload; analytical method; anticancer research; base; cancer research; cell type; cellular development; clinical care; cohort; computerized; disease/disorder; drug/agent; heavy metal Pb; heavy metal lead; imaging; improved; infrared microscopy; insight; instrument; instrumentation; language translation; malignancy; men; men's; model organism; neoplasm/cancer; new approaches; new technology; novel; novel approaches; novel strategies; novel strategy; prognostic; public health relevance; response; senescent; spectroscopic imaging; surgery; tumor",Infrared microscopy for a systems approach to prostate pathology," Project narrative The major goal of this project is to leverage novel chemical imaging technology to identify those truly at risk of death from prostate cancer. To achieve this goal, we develop novel chemical imaging technology that can measure the spatial and molecular content of tissue as without the use of dyes or labels. Analytical methods will be developed to extract information from the measurements and relate it to biochemical knowledge of the prostate. A systems pathology approach, finally, is presented to predict those at risk. The project has the potential to transform therapy decisions for patients by identifying aggressive and indolent lesions accurately. This would enable focusing of resources on ~40,000 patients who have lethal disease and avoid wasteful expenditures on ~200,000 people. If successful, establishment of the instrumentation and analytical methods here would alter the standard practice in clinical histologic assessment of research in prostate cancer.",138882,MI,Microscopic Imaging Study Section,A1,1,301604,
7785321,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA138937-01A1,,NCI:305763;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"BALDWIN, ALBERT SIDNEY;",1865037;,1R01CA138937,02/01/2010,12/31/2014,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 3-10C; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; AMCF-I; Activation, Gene; Address; Adriamycine; African American; Afro American; Afroamerican; Animal Cancer Model; Animal Disease Models; Animal Model; Animal Models and Related Studies; AnimalModel; Animals; Apoptosis; Apoptosis Pathway; Black Populations; Black or African American; Breast Cancer Cell; Breast Neoplasms; Breast Tumors; CASP8 and FADD-like apoptosis regulating protein; CXCL8; Cancer Patient; Cancer Treatment; Cancer cell line; Cancer of Breast; Cancers; Casper protein; Categories; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Clinical; DOX; Data; Development; Disease; Disorder; Doxorubicin; Doxorubicina; Drugs; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Exhibits; Expression Profiling; Expression Signature; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FLICE-inhibitory protein; FLIP (cellular); FRAP1 protein, human; Forecast of outcome; GCP-1; GCP1; Gene Activation; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profile; Gene Expression Profiling; Gene Targeting; Genentech brand of trastuzumab; Generalized Growth; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic Models; Genetic defect; Growth; HER1; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic Cancer; Herceptin; Heterogeneity; Heterograft; Hoffman-La Roche brand of trastuzumab; Human; Human Breast Cancer Cell; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; IL-8; IL8; IL8 gene; Immunoglobulin Enhancer-Binding Protein; Intracellular Communication and Signaling; K60; Knock-in; Knock-in Mouse; LECT; LUCT; LYNAP; MDNCF; MONAP; Malignant Cell; Malignant Hematologic Neoplasm; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Medication; Mice; Mice, Transgenic; Models, Genetic; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutation; NAF; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Oncogenic; Outcome; P53; Pathologic; Pathway interactions; Patients; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Pre-Menopause; Pre-menopausal Period; Predictive Value; Premenopausal; Premenopausal Period; Premenopause; Profilings, Gene Expression; Prognosis; Property; Property, LOINC Axis 2; Proteins; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Regulatory Pathway; Reporting; Resistance; Roche brand of trastuzumab; Role; SCYB8; SUBGP; Sampling; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Solid Neoplasm; Solid Tumor; Subgroup; TIL4; TLR2; TLR2 gene; TP53; TP53 gene; TRP53; TSG-1; Targetings, Gene; Testing; Therapeutic; Tissue Growth; Toll/Interleukin 1 Receptor-Like 4 Gene; Transcript Expression Analyses; Transcript Expression Analysis; Transcription Factor NF-kB; Transforming Growth Factor alpha Receptor; Transgenic Mice; Transplantation, Heterologous; Tumor Cell; Tumor Cell Line; Tumor Protein p53 Gene; Tumor Subtype; Tumor-Derived; Woman; Work; Xenograft; Xenograft procedure; Xenotransplantation; anticancer therapy; b-ENAP; base; biological signal transduction; black American; c-FLIP; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer progression; cancer therapy; cancer type; cell growth; chemotherapy; cultured cell line; disease/disorder; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gene expression signature; gene product; genome mutation; human FRAP1 protein; human tissue; inhibitor; inhibitor/antagonist; insight; interest; intervention development; kappa B Enhancer Binding Protein; mTOR; malignancy; malignant breast neoplasm; mammary tumor; model organism; molecuar profile; molecular signature; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new therapeutics; next generation therapeutics; novel therapeutics; nuclear factor kappa beta; ontogeny; outcome forecast; p65; pathway; pre-menopausal; proto-oncogene protein c-erbB-1; public health relevance; rapamycin and FKBP12 target 1 protein, human; research study; resistant; response; social role; therapy development; transcription factor; transcriptome; treatment development; tumor; tumor initiation; tumor progression",Regulation of Basal-Like and Her2+ Breast Cancer Phenotypes by IKK/NF-kappaB," Project Narrative While activation of the transcription factor NF-¨B is associated with hematologic malignancies and with solid tumors, there are only a few studies using specific inhibitors of the NF-¨B pathway in animal models of cancer. NF-¨B is activated by both IKK¨ and IKK¨, and no efforts have been directed at blocking total IKK in tumor cells. Additionally, there are no inhibitor studies directed at targeting the ability of IKK to control other key pro-oncogenic pathways (separate from NF-¨B). Our effort is directed towards understanding the role of NF-¨B in two breast tumor subtypes with poor prognosis: basal-like cancers and Her2/ErbB2+ cancers. Preliminary data indicate that different forms of NF-¨B are activated in these cancers leading to the regulation of distinct sets of genes. Interestingly, genes expressed in human basal-like or Her2+ cancers are also expressed in human cancer cell lines and in animal models for these breast cancer subtypes. We will explore the regulatory pathways associated with NF-¨B activation and function in these two types of cancer, with additional studies focused on the ability of IKK to control Akt in these cells. Based on encouraging preliminary data, we will utilize genetic models and we will test highly specific inhibitors of IKK¨ and IKK¨ (key upstream regulators of NF-¨B) in cell lines and in animal models to test the involvement of this pathway in controlling oncogenic development/progression and in regulating resistance to key cancer therapeutics. In this regard, we are hopeful that our experiments will provide new therapeutic options for forms of breast cancer with poor outcome. Additionally, our studies will provide unique insight into the functions of different signaling pathways associated with NF-¨B in controlling oncogenic phenotypes.",138937,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,A1,1,305763,
7779140,R01,CA,1,,01/01/2010,12/31/2010,PA-07-070,1R01CA139319-01A1,,NCI:362088;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073724262,US,PA,191112434,FOX CHASE CANCER CENTER,"MURPHY, MAUREEN E;",1933733;,1R01CA139319,01/01/2010,12/31/2014,"1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-; 1-Phosphatidylinositol 3-Kinase; 3-methyladenine; ARF; ARF tumor suppressor, mouse; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Abbreviations; Address; Amino Acids; Annexin A2; Annexin II; Annexin II, P36; Anti-Cancer Agents; Anti-Oncogenes; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogenes; Antiproliferative Agents; Antiproliferative Drugs; Atrophic Arthritis; Autophagocytosis; B23 Nuclear Matrix Protein; Binding; Binding (Molecular Function); Binding Proteins; Biochemistry; Blood Coagulation Factor IV; Breast Carcinoma; Buffers; Burkitt Lymphoma; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; CDK4I; CDKN2; CDKN2A; CDKN2A gene; CMM2; Ca++ element; Calcium; Cancer Drug; Cancer Treatment; Cancers; Capactin I Heavy Chain; Catabolic Process; Cdkn2a(p19ARF); Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Chemicals; Chemistry, Biological; Chemotherapeutic Agents, Neoplastic Disease; Chlorochin; Chloroquine; Coagulation Factor IV; Connective Tissue Sarcoma; Cyclin-Dependent Kinase Inhibitor 2A Gene; D-Glucose; Data; Development; Dextrose; Digestion; Disaccharides; Drugs; E2F-1; E2F1; E2F1 gene; EC 2.7; Emerogenes; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Factor IV; Foundations; Gene Down-Regulation; Generalized Growth; Genes; Genes, CDKN2; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p16; Genes, p16INK4A; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Germinoblastoma; Glucose; Goals; Growth; Heel; Human; Human, General; INK4; INK4A; Inflammatory Arthritis; Intracellular Communication and Signaling; Khingamin; Kinases; Ligand Binding Protein; Lipids; Lipocortin II; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lysosomes; MDM 2; MDM2; MDM2 gene; MLM; MTS1; MTS1 Genes; Malaria; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Soft Tissue; Mammals, Mice; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane; Metabolic stress; Mice; Mitochondria; Mitochondrial Proteins; Molecular Interaction; Murine; Mus; Mutate; Mutation; N(3)-methyladenine; NPM1; NUMATRIN; Nucleolar Phosphoprotein B23; Nutrient; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Organelles; Ovarian; P53; PI-3 Kinase; PI-3K; PI3-Kinase; PI3-Kinase Inhibitors; Paludism; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatides; Phosphatidylinositide 3-Kinase Inhibitor; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phospholipids; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Plasmodium Infections; Play; Process; Proteins; PtdIns 3-Kinase; Public Health; RAFT1 protein, human; RAPT1 protein, human; RBBP3; RBP3; Rapamycin Target Protein; Research; Reticulolymphosarcoma; Rheumatoid Arthritis; Role; Sarcoma of the Soft Tissue and Bone; Sarcoma, Germinoblastic; Sarcoma, Soft Tissue; Signal Transduction; Signal Transduction Systems; Signaling; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Sodium Chloride; Sodium chloride (NaCl); Solutions; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Starvation; Stress; TP16; TP53; TP53 gene; TRP53; TSG9A; Terminology; Testing; Tissue Growth; Transcription Repression; Transcriptional Repression; Transphosphorylases; Trehalose; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tumor-Specific Treatment Agents; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Up-Regulation; Up-Regulation (Physiology); Upregulation; alpha-D-Glucopyranoside, alpha-D-glucopyranosyl; aminoacid; anticancer agent; anticancer drug; anticancer therapy; autophagy; biological signal transduction; c myc; c-myc Genes; cancer cell; cancer therapy; cell transformation; combat; cultured cell line; d-Numb; deprivation; drug/agent; gene product; gene repression; genome mutation; human FRAP1 protein; in vivo; inhibitor; inhibitor/antagonist; mTOR; malignancy; membrane structure; mitochondrial; mutant; neoplasm/cancer; neoplastic cell; novel; nucleolar protein B23; nucleophosmid; nucleophosmin; numb protein; oncosuppressor gene; ontogeny; overexpression; p14ARF; p16INK4 Genes; p16INK4a; p19(ARF); p19(ARF) protein; p19(ARF) protein, mouse; p19ARF; p53-Binding Protein Gene; pathway; protein B23; public health medicine (field); public health relevance; rapamycin and FKBP12 target 1 protein, human; response; salt; sarcoma; small molecule; social role; transformed cells; tumor; tumor suppressor; tumorigenesis; ubiquitin ligase; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",The ARF Tumor Suppressor," PUBLIC HEALTH STATEMENT The ARF gene is encoded by the Ink4a/ARF locus, which is the second most commonly mutated genetic locus in human cancer; up to 50% of human tumors contain mutations in Ink4a/ARF. This fact argues that research aimed at understanding the basic function of ARF in human cancer is warranted. We show that ARF controls a key survival pathway for tumor cells. We believe that the requirement for ARF and autophagy may be an Achilles Heel for tumor cells. This research is aimed at understanding this pathway, and at finding ways to manipulate this pathway to combat cancer.",139319,CAMP,Cancer Molecular Pathobiology Study Section,A1,1,362088,
7842343,R01,CA,1,,02/01/2010,01/31/2011,PA-07-455,1R01CA139984-01A1,,NCI:303988;,2010,NATIONAL CANCER INSTITUTE,,SHREVEPORT,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,04,095439774,US,LA,71103,LOUISIANA STATE UNIV HSC SHREVEPORT,"TIBBETTS, SCOTT A;",8882386;,1R01CA139984,02/01/2010,01/31/2015,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Associated Viruses; Attenuated; B blood cells; B-Cells; B-Lymphocytes; Burkitt Herpesvirus; Burkitt Lymphoma Virus; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Data; Defective Hybrids; Defective Interfering Particles; Defective Interfering Viruses; Defective Viruses; Development; Disease; Disorder; E-B Virus; EB virus; EBV; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Episome; Epstein Barr Virus; Epstein-Barr Virus; Event; Gene Expression; Genes; Genes, Viral; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Goals; HDAC; HDAC Proteins; HHV-4; HHV-8; HHV8; HIV; HTLV-III; Herpesviridae; Herpesviridae Infections; Herpesviridae disease; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesvirus Infections; Herpesviruses; Histone Deacetylase; Histone Deacetylation; Histones; Hour; Human; Human Herpesvirus 4; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Incomplete Viruses; Infection; Infectious Mononucleosis Virus; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; LAV-HTLV-III; Laboratories; Life; Link; Lymphadenopathy-Associated Virus; Lytic; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Method LOINC Axis 6; Methodology; Mice; Modality; Modification; Molecular; Murine; Mus; Mutate; Mutation; Patients; Phase; Physiologic; Physiological; Populations at Risk; Process; Proteins; Recombinants; Research; Risk; Role; Satellite Viruses; Staging; System; System, LOINC Axis 4; Testing; Therapeutic; Time; Transplant Recipients; Viral; Viral Genes; Viral Genome; Virus; Virus-HHV8; Virus-HIV; Viruses, General; Work; attenuation; cancer type; design; designing; disease/disorder; drug development; gammaherpesvirus; gene product; genome mutation; herpes virus; human herpesvirus 4 group; human herpesvirus 8; immunosuppressed patient; in vivo; infected B cell; infected B lymphocyte; insight; latent infection; lytic replication; lytic viral replication; lytic virus replication; maintenance of viral episome; maintenance of virus episome; malignancy; mutant; neoplasm/cancer; novel marker; prevent; preventing; public health relevance; social role; tool; transplant patient; virus episome maintenance",Role of gammaherpesvirus lytic replication-associated genes in the establishment," Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus infections are linked to the development of numerous types of cancers, and pose a particularly significant risk to AIDS patients and transplant recipients. The proposed research will examine the events that occur in the earliest stages of infection in an effort to gain new insight into the means by which these viruses establish lifelong infections. This work has important implications for the development of drugs to prevent or treat virus-associated cancers.",139984,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,A1,1,303988,
7899319,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA140432-01A2,,NCI:313533;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","DATTA, KAUSTUBH ;",7697429;,1R01CA140432,02/01/2010,01/31/2015,"Ablation; Address; Androgenic Agents; Androgenic Compounds; Androgens; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; BZS; Body Tissues; Cancer Cause; Cancer Etiology; Cancer Patient; Cancer Radiotherapy; Cancer of Lung; Cancer of Prostate; Cancers; Cell Death, Programmed; Cellular Stress; Cessation of life; Clinical Research; Clinical Study; Complex; Cutaneous; Death; Development; Disease; Disorder; Electromagnetic Radiation, Ionizing; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FLR; FLT4 Ligand; FLT4-L; FRAP1 protein, human; Failure (biologic function); Frequencies (time pattern); Frequency; Goals; Hormonal; Human; Human, General; Hypoxia; Hypoxic; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Vitro; Ionizing radiation; Knockout Mice; Lymph node proper; Lymphangiogeneses; Lymphangiogenesis; Lymphatic vessel; MHAM; MMAC1; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Prostate; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Prostate Cancer; Metastatic Tumor; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Mortality; Mortality Vital Statistics; Murine; Mus; NKX3-1 gene; NKX3.1; NKX3A; NRP2 Protein; Neoplasm Metastasis; Neuropilin-2; Npn-2 Protein; Null Mouse; Outcome; Oxidative Stress; Oxygen Deficiency; PTEN; PTEN gene; PTEN1; Pathway interactions; Patients; Phosphatase and Tensin Homolog; Process; Prostate CA; Prostate Cancer; Prostate Carcinoma Metastatic; Prostatectomy; Prostatic Cancer; Publications; Pulmonary Cancer; Pulmonary malignant Neoplasm; RAFT1 protein, human; RAPT1 protein, human; Radiation; Radiation therapy; Radiation-Ionizing Total; Radiotherapeutics; Radiotherapy; Rapamycin Target Protein; Receptor Protein; Recurrence; Recurrent; Refractory; Research Specimen; Resistance; Reticuloendothelial System, Lymph Node; Role; Scientific Publication; Secondary Neoplasm; Secondary Tumor; Specimen; Staging; Stream; Stress; Therapeutic Androgen; Therapeutic Intervention; Tissues; Transgenic Mice; Transgenic Organisms; Tumor Cell Migration; VEGF-C; VEGFC; VRP; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor Related Protein; Western World; cancer cell; cancer metastasis; cancer recurrence; cohort; deprivation; disease/disorder; effective therapy; failure; human FRAP1 protein; immunosuppressed patient; implantation; intervention therapy; irradiation; lung cancer; lymph gland; lymph nodes; mTOR; malignancy; meetings; men; men's; model organism; mouse model; neoplasm/cancer; new growth; novel; paracrine; pathway; prognostic; prognostic indicator; public health relevance; rapamycin and FKBP12 target 1 protein, human; ray (radiation); receptor; resistance to therapy; resistant; resistant to therapy; social role; therapeutic target; therapy resistant; tissue culture; transgenic; tumor",The role of VEGF-C in resisting stress in prostate cancer, Relevance: This proposal will help to understand the mechanism of metastatic progression of prostate cancer and is therefore important for the development of novel and effective therapies. It will also help to predict the outcome of currently available therapies in prostate cancer patients like radiation and hormonal ablation.,140432,TPM,Tumor Progression and Metastasis Study Section,A2,1,313533,
7781632,R01,CA,1,,01/18/2010,12/31/2010,PA-07-070,1R01CA140471-01A1,,NCI:316438;,2010,NATIONAL CANCER INSTITUTE,,TEMPE,UNITED STATES,MISCELLANEOUS,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"HECHT, SIDNEY M.;",8231162;,1R01CA140471,01/18/2010,12/31/2014,"Address; Affinity; Antibiotics, Antineoplastic; Anticancer Antibiotic; B-DNA; Binding; Binding (Molecular Function); Bleo; Bleomycin; Bleomycin Antibiotic; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell surface; Characteristics; Chemotherapy, Antibiotics; Chemotherapy, Cancer, Antibiotics; Cleaved cell; DNA; DNA Binding; DNA Binding Interaction; DNA, B Form; Deoxyribonucleic Acid; Diagnosis; Disaccharides; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elements; Family; Gene Products, RNA; Germinoblastoma; Glycopeptides; Goals; In-bleomycin; Investigation; Lundbeck Brand of Bleomycin Sulfate; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Malignant Cell; Mediating; Methods; Molecular; Molecular Interaction; Monitor; Nucleic Acids; Physiologic; Physiological; Preparation; Property; Property, LOINC Axis 2; RNA; RNA, Non-Polyadenylated; Research; Reticulolymphosarcoma; Ribonucleic Acid; Right-Handed DNA; Sarcoma, Germinoblastic; Squamous Cell Epithelioma; Squamous cell carcinoma; Streptomyces; Tumor Tissue; analog; antineoplastic antibiotics; antitumor agent; antitumor antibiotics; base; cancer cell; cleaved; improved; indium-bleomycin; molecular recognition; public health relevance; soft tissue; tumor",Molecular Recognition by Bleomycin," Project Narrative The bleomycins are used clinically for the treatment of certain tumors that occur in soft tissues. The studies proposed here will facilitate an understanding of the way that this drug targets tumors, and binds to and degrades the nucleic acids in tumor tissue. As such, these studies will enable the preparation of bleomycins with improved properties.",140471,SBCA,Synthetic and Biological Chemistry A Study Section,A1,1,316438,
7929373,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA142362-01A2,,NCI:306063;,2010,NATIONAL CANCER INSTITUTE,,CHARLESTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"PARSONS, CHRISTOPHER H;",6932711;,1R01CA142362,02/01/2010,12/31/2014,"AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Amino Acids; Autocrine Systems; Binding; Binding (Molecular Function); Blood Circulation; Blood Serum; Blood monocyte; Bloodstream; Buccal Cavity; Cancers; Cavitas Oris; Cell Culture System; Cell Death; Cell Line; Cell Lines, Strains; Cell Survival; Cell Viability; CellLine; Cells; Circulation; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Study; Common Neoplasm; Common Tumor; Data; EC 1.14.13.39; EDRF Synthase; Endothelial Cells; Endothelium-Derived Growth Factor Synthase; Environment; Exhibits; Future; Gene Transcription; Gene Transfer; Generations; Genetic Transcription; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Guanylyl Cyclase-Activating Factor Synthase; HHV-8; HHV8; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Head and Neck, Buccal Cavity; Herpesviridae Infections; Herpesviridae disease; Herpesvirus Infections; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Infection; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); LAV-HTLV-III; Length of Life; Lesion; Link; Longevity; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Membrane; Membrane Transport Proteins; Membrane Transporters; Mice; Micro RNA; MicroRNAs; Molecular Interaction; Mononuclear; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouth; Multiple Hemorrhagic Sarcoma; Murine; Mus; NADPH-Diaphorase; NO Synthase; Natural immunosuppression; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Oral cavity; Oxidative Stress; PBMC; Pathogenesis; Patients; Peripheral; Peripheral Blood Mononuclear Cell; Permissivenesses; Play; Prevention; Preventive; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Subunits; Proteins; RNA Expression; Reactive Nitrogen Species; Receptor Protein; Receptors, Virus; Regulation; Regulatory Pathway; Relative; Relative (related person); Risk; Role; Sampling; Science; Serum; Source; Stress; T-Lymphotropic Virus Type III Infections, Human; Toxic effect; Toxicities; Transcription; Transcription, Genetic; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral Receptor; Virus Receptors; Virus-HHV8; Virus-HIV; aminoacid; autocrine; base; cell type; cultured cell line; design; designing; experiment; experimental research; experimental study; extracellular; functional outcomes; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gammaherpesvirus; gene product; human herpesvirus 8; immunosuppression; life span; lifespan; macrophage; malignancy; membrane structure; men who have sex with men; men who have sex with other men; miRNA; monocyte; necrocytosis; neoplasm/cancer; new therapeutics; next generation therapeutics; novel; novel therapeutics; paracrine; peripheral blood; permissiveness; public health relevance; receptor; research study; skin lesion; social role; therapeutic target; transfer of a gene; treatment strategy; tumor",Regulation of the Tumor Microenvironment by KSHV," PROJECT NARRATIVE Tumors etiologically linked to the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), including Kaposi's sarcoma (KS), are among the most common tumors encountered in the setting of HIV infection and other forms of immune suppression. KS remains an important cause of morbidity and mortality for these patients in the modern era, and the efficacy and toxicity of available therapies for KS are limiting. Therefore, understanding mechanisms for how KSHV regulates expression of its own receptors and the longevity of KSHV-infected cells could provide a scientific basis for developing novel preventive and therapeutic targets for KS.",142362,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,A2,1,306063,
7766552,R01,CA,1,,02/01/2010,01/31/2011,PAR-07-214,1R01CA142575-01,,NCI:644525;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BOAS, DAVID A;",1888665;,1R01CA142575,02/01/2010,01/31/2015,"Accounting; Active Follow-up; Adipose tissue; Affect; Algorithms; American Cancer Society; Anxiety; Benign; Biomechanics; Biopsy; Blood flow; Boa; Body Tissues; Breast; Breast Cancer Detection; Breast Tissue; Breast cancer screening; Cancer Staging; Cancer of Breast; Cancer of Lung; Cancers; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Collaborations; Complement; Complement Proteins; Conventional X-Ray; Custom; Cyst; Data; Development; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Diagnostic Radiology; Diagnostic radiologic examination; Digital Mammography; Digital X-Ray; Disease; Disorder; Early Diagnosis; Early-Stage Clinical Trials; Engineering; Engineerings; Evolution; Fatty Tissue; Female; Fiber Optics; Functional Imaging; Goals; Health Care Costs; Health Costs; Healthcare Costs; Hemoglobin; Image; Image Reconstructions; Imaging Procedures; Imaging Techniques; Imaging technology; Instrumentation, Other; Lesion; Letters; MMG; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Lung; Malignant Tumor of the Skin; Malignant neoplasm of breast; Malignant neoplasm of lung; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammogram; Mammography; Measurement; Measures; Mechanics; Medical Imaging; Medical Imaging, X-Ray; Melanoma and Non-Melanoma Skin Cancer; Metabolic; Metabolic Marker; Mortality; Mortality Vital Statistics; Neoplasm Staging; Newly Diagnosed; Normal Tissue; Normal tissue morphology; Optics; Oxygen Consumption; Patients; Performance; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Physiologic Imaging; Population; Position; Positioning Attribute; Procedures; Process; Property; Property, LOINC Axis 2; Pulmonary Cancer; Pulmonary malignant Neoplasm; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Radiography; Radiology, Diagnostic X-Ray; Reconstructions, Image; Resolution; Roentgen Rays; Roentgenography; Screening procedure; Sensitivity and Specificity; Skin Cancer; Skin Cancer, Including Melanoma; Specificity; System; System, LOINC Axis 4; Technics, Imaging; Technology; Testing; Time; Tissues; Tumor Staging; Variant; Variation; Woman; X-Radiation; X-Ray Imaging; X-Ray, Diagnostic; X-Rays; Xrays; adipose; angiogenesis; biomarker; breast cancer diagnosis; calcification; clinical investigation; digital; disease/disorder; early detection; effectiveness trial; experience; follow-up; imaging; imaging modality; improved; instrumentation; interest; lung cancer; malignancy; malignant breast neoplasm; mammary cancer detection; neoplasm/cancer; optic imaging; optical imaging; phase 1 study; phase 1 trial; phase I trial; prognostic; protocol, phase I; prototype; public health relevance; response; screening; screenings; white adipose tissue; yellow adipose tissue",Integrated 3D Xray and Dynamic Tomographic Optical Breast Imaging System," Project Narrative Development of optical cancer markers may improve sensitivity of x-ray mammography, leading to fewer missed early stage cancers; at the same time, improvements in specificity may decrease the number of un-necessary biopsies, thus reducing both patient anxiety and health care costs.",142575,ZRG1,Special Emphasis Panel,,1,644525,
7765922,R01,CA,1,,01/19/2010,12/31/2010,PA-07-070,1R01CA142664-01,,NCI:318513;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"YOTNDA, PATRICIA ;",7746882;,1R01CA142664,01/19/2010,12/31/2014,"ATGN; Active Oxygen; Address; Adoptive Transfer; Affect; Anoxia, Cellular; Antigen Receptors; Antigens; Antioxidants; Apoptosis; Apoptosis Pathway; Apoptotic; Area; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Behavior; Biological; CTL; Cancers; Cell Anoxia; Cell Death; Cell Death, Programmed; Cell Function; Cell Hypoxia; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cell-Mediated Lympholytic Cells; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Transformation; Clinical; Clinical Research; Clinical Study; Co-Stimulator; Costimulator; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; DHQU; DIA4; DT-diaphorase; DTD; Data; Dependence; Development; Diaphorase (NADH/NADPH); Diaphorase-4; EBV-Specific Cytotoxic T-Lymphocyte; EBV-associated malignancy; EBV-specific CTL; Effectiveness; Effector Cell; Engineering; Engineerings; Environment; Epidermal Thymocyte Activating Factor; Epstein-Barr Virus associated malignancy; Epstein-Barr virus-specific cytotoxic T-lymphocytes; Exposure to; FLR; Failure (biologic function); Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Generations; Genes; Genetic Intervention; Germinoblastoma; Growth; H2O2; Homing; Human; Human Engineering; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypoxia; Hypoxia, Cellular; Hypoxia-Responsive Elements; Hypoxic; IL-15; IL-15 Gene; IL-2; IL15; IL15 Protein; IL15 gene; IL2; IL2 Protein; ITX; Immune; Immune Escape, Tumor; Immune response; Immunologically Directed Therapy; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunotherapy; In Vitro; Infusion; Infusion procedures; Institution; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-15; Interleukin-15 Gene; Interleukin-15 Precursor; Interleukin-15 Precursor Gene; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intervention, Genetic; Killings; Life; Lymphocyte Mitogenic Factor; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lytotoxicity; MGC9721; MGC9721 Gene; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant; Malignant - descriptor; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Mediating; Memory; Menadione Reductase; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mitogenic Factor; Modeling; Modification; Molecular Biology, Gene Therapy; NAD(P)H Dehydrogenase (Quinone) 1; NAD(P)H dehydrogenase (quinone) 1, human; NAD(P)H[{..}]Quinone Oxidoreductase; NADPH[{..}]Quinone Reductase; NMOR1; NMORI; NQO1; NQO1 gene; NQO1 protein; NQO1 protein, human; Natural immunosuppression; Neoplasm Metastasis; Non-Malignant; O element; O2 element; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen; Oxygen Deficiency; Oxygen Radicals; Oxygen measurement, partial pressure, arterial; Patients; Phenotype; Phylloquinone Reductase; Play; Pro-Oxidants; Production; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; QR1; Quinone Oxidoreductase; Radio; Reactive Oxygen Species; Receptor Protein; Receptors, Antigen; Receptors, Antigen, T-Cell; Regulatory T-Lymphocyte; Research Resources; Resistance; Resources; Reticulolymphosarcoma; Role; Safety; Sarcoma, Germinoblastic; Secondary Neoplasm; Secondary Tumor; Series; Site; Subcellular Process; System; System, LOINC Axis 4; T cell growth factor; T-Cell Growth Factor; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; Testing; Therapy, DNA; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Tissue Growth; Toxic effect; Toxicities; Transgenic Organisms; Translational Research; Translational Research Enterprise; Translational Science; Tumor Antigens; Tumor Cell Migration; Tumor Escape; Tumor-Associated Antigen; Up-Regulation; Up-Regulation (Physiology); Upregulation; Xenograft Model; Zeta-Crystallin; anti-oxidant; arterial pO2; base; cancer metastasis; cell engineering; cellular engineering; cytokine; cytotoxic; cytotoxicity; diaphorase 4, human; electron acceptor; failure; gene product; gene therapy; genetic therapy; host response; immune therapy; immunogen; immunoresponse; immunosuppression; immunosuppressive; improved; in vivo; malignancy; melanoma; metaplastic cell transformation; necrocytosis; neoplasm/cancer; nonmalignant; ontogeny; overexpression; oxygen tension; preclinical study; prevent; preventing; public health relevance; quinone reductase 1, human; receptor; receptor expression; research facility; resistant; restoration; social role; success; thymus derived lymphocyte; transgenic; translation research enterprise; tumor; tumor specificity; tumor-specific antigen",Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.," Narrative Studies involving infusion of tumor-specific T cell into patients have shown that T cells persistence and survival is affected by tumor escape mechanisms. We will reinforce the activity, persistence, and overall effectiveness of T cells by increasing their resistance to hypoxia- and oxidant-mediated immunosuppression.",142664,CII,Cancer Immunopathology and Immunotherapy Study Section,,1,318513,
7766538,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA142698-01,,NCI:360358;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"CHOWDHURY, DIPANJAN ;",9393422;,1R01CA142698,02/01/2010,01/31/2015,"Address; Algorithms; Alimentary Canal; Apoptosis; Apoptosis Pathway; Assay; Attenuated; B-Cell CLL; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; BRCA1; BRCA1 gene; Bio-Informatics; Bioassay; Biochemical; Bioinformatics; Biologic Assays; Biological Assay; Blood Cells; Breast; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer Type 1 Susceptibility Gene; Cancer Biology; Cancer Radiotherapy; Cancer Treatment; Cancers; Cell Death; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Line, Transformed; Cell Lines, Strains; CellLine; Cells; Central Nervous System; Chromosomal Breakage; Chromosome Breakage; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Clinical; Comet Assay; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Repair; DNA Repair Gene; DNA Repair Pathway; DNA repair protein; Digestive Tract; Electromagnetic Radiation, Ionizing; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Pulsed-Field Gradient; Expression Profiling; Expression Signature; Forecast of outcome; Fractionation, Pulse Field; Functional RNA; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gel Electrophoresis, Single-Cell; Gene Expression; Gene Targeting; Genital System, Female, Ovary; Genital System, Male, Prostate; Goals; Hematopoietic; Hereditary Breast Cancer 1; Housing; Human Prostate; Human Prostate Gland; In Vitro; Interphase Cell; Ionizing radiation; Kidney; Leukemia, B-Cell; Lung; Lymphoblastic Leukemia, Chronic; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; Malignant Cell; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Measures; Mediating; Messenger RNA; Micro RNA; MicroRNAs; Mitotic; Molecular Fingerprinting; Molecular Profiling; Monitor; NHEJ; Nervous System, CNS; Neuraxis; Non-Coding; Non-Coding RNA; Non-Homologous End Joining; Non-dividing Cell; Nonhomologous DNA End Joining; Normal Cell; Oncogenesis; Ovary; PFGE; PSCP; Pathway interactions; Peripheral Blood Cell; Phenotype; Production; Prognosis; Prostate; Prostate Gland; Prostatic Gland; Proteins; RNA, Messenger; RNF53; Radiation; Radiation Sensitivity; Radiation Tolerance; Radiation therapy; Radiation-Ionizing Total; Radiosensitivity; Radiotherapeutics; Radiotherapy; Reagent; Reporter; Resistance; Resistance development; Resistant development; Respiratory System, Lung; Resting Cell; Role; Specificity; System; System, LOINC Axis 4; Targetings, Gene; Transcript; Transformed Cell Line; Tumor Cell; Unscheduled DNA Synthesis; Urinary System, Kidney; alimentary tract; anticancer therapy; attenuation; brca 1 gene; cancer cell; cancer therapy; chemotherapeutic agent; chronic lymphoid leukemia; cultured cell line; cytotoxic; developing resistance; digestive canal; experiment; experimental research; experimental study; gene product; homologous recombination; irradiation; mRNA; malignancy; melanoma; member; miRNA; molecuar profile; molecular signature; necrocytosis; neoplasm/cancer; neoplastic cell; novel; outcome forecast; overexpression; pathway; public health relevance; pulmonary; ray (radiation); renal; repair; repaired; research study; resistance to therapy; resistant; resistant to therapy; response; social role; therapy resistant; tumor; tumorigenesis",Investigate role of microRNA cluster 183-96-182 in DNA repair and radiosensitivit," Radiation and chemotherapeutic agents eradicate tumors by inducing irreparable DNA damage, and cancer cells often counter this treatment by manipulating the DNA repair machinery to develop resistance. In our preliminary studies we have discovered a novel connection between a new class of gene expression regulators, microRNAs (miRNAs) and DNA repair proteins, and the miRNAs (182, 183 and 96) that we propose to investigate have already been recognized for aberrant expression in a variety of tumors. Identifying specific miRNAs that suppress DNA repair, and their functional impact upon the DNA repair pathways, and radiosensitivity of cells, will have significant clinical implications in cancer biology.",142698,RTB,Radiation Therapeutics and Biology Study Section,,1,360358,
7766172,R01,CA,1,,02/01/2010,12/31/2010,PA-07-070,1R01CA142737-01,,NCI:292639;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"BRACE, CHRISTOPHER L;",8491835;,1R01CA142737,02/01/2010,12/31/2013,"Ablation; Adoption; Affect; Algorithms; Area; Arts; Blood flow; Body Tissues; Body part; Bone; Bone and Bones; Bones and Bone Tissue; Cancer Treatment; Cancer, Oncology; Cancerous; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Crossmatching, Tissue; Cryoablation; Cryosurgery; Data; Development; Devices; Electric Conductivity; Electrical Conductivity; Electromagnetic, Laser; Electromagnetic, Microwave; Engineering; Engineerings; Equipment; Frequencies (time pattern); Frequency; Generalized Growth; Growth; Heating; Histocompatibility Testing; Human; Human, General; Hybrids; Image; Killings; Knowledge; Lasers; Liver; Lung; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Medical; Medicine; Methods and Techniques; Methods, Other; Microwaves; Modality; Modeling; Monitor; Operation; Operative Procedures; Operative Surgical Procedures; Patient Care; Patient Care Delivery; Patients; Performance; Phase; Physiologic pulse; Plague; Preclinical Testing; Procedures; Property; Property, LOINC Axis 2; Protocols, Treatment; Pulse; Puncture procedure; Punctures; RF ablation; RGM; Radiation, Laser; Radio Frequency Ablation; Radiofrequency Ablation; Radiofrequency Interstitial Ablation; Recurrence; Recurrent; Regimen; Reporting; Respiratory System, Lung; Role; Science of Medicine; Source; Specificity; Speed; Speed (motion); Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Technology; Thermal Ablation Therapy; Time; Tissue Crossmatchings; Tissue Growth; Tissue Model; Tissue Typing; Tissues; Translations; Treatment Efficacy; Treatment Protocols; Treatment Regimen; Treatment Schedule; Yersinia pestis disease; anticancer therapy; base; body system, hepatic; bone; cancer care; cancer therapy; clinical efficacy; clinical investigation; clinical practice; clinical relevance; clinically relevant; cryogenics; design; designing; electrical conductance; experience; histocompatibility typing; imaging; improved; industry partner; innovate; innovation; innovative; interstitial; intervention design; microwave electromagnetic radiation; microwave radiation; minimally invasive; oncology; ontogeny; organ system, hepatic; patient population; public health relevance; pulmonary; radiofrequency; simulation; social role; stem; surgery; therapeutic efficacy; therapeutically effective; therapy design; thermal ablation; tool; treatment design; tumor",Optimizing microwave ablation techniques for targeted cancer therapy," PROJECT NARRATIVE This proposal will combine the best of engineering and medicine to better understand how ablations are created, develop tools for improved system design, and create a cancer treatment platform that requires minimal invasiveness to provide maximal patient benefit.",142737,RTB,Radiation Therapeutics and Biology Study Section,,1,292639,
7899344,R01,CA,1,,03/01/2010,12/31/2010,PA-07-070,1R01CA142776-01A1,,NCI:331309;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,OBSTETRICS & GYNECOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"ZHANG, LIN ;",8904530;,1R01CA142776,03/01/2010,12/31/2014,"Adenovirus E1b19k-Binding Protein B5 Gene; Animal Model; Animal Models and Related Studies; Anoxia, Cellular; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a Gene; BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like Gene; BNIP3A Gene; BNIP3L; BNIP3L gene; Biological Function; Biological Process; Breast; Breast Neoplasms; Breast Tumors; Cancer Biology; Cancer Cause; Cancer Etiology; Cancer Genes; Cancer Patient; Cancer of Breast; Cancer of the Ovary; Cancer stem cell; Cancer-Promoting Gene; Cancers; Cell Anoxia; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Hypoxia; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Clinical; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Collection; DNA copy number; Development; Diagnosis; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Disease; Disorder; Emerogenes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial; Epithelium; Exhibits; Faculty; Figs; Figs - dietary; Frequencies (time pattern); Frequency; Functional RNA; Funding; Gene Expression; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic Condition; Genetic Diseases; Genomics; Goals; Grant; Hereditary Disease; Heterograft; Human; Human, General; Hypoxia; Hypoxia, Cellular; Hypoxic; In Vitro; Intracellular Communication and Signaling; Investigation; Laboratories; Learning; Libraries; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Ovary; Malignant neoplasm of breast; Malignant neoplasm of ovary; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Man (Taxonomy); Man, Modern; Maps; Mice, Transgenic; Micro RNA; MicroRNAs; Modification; Molecular; Molecular Disease; Mortality; Mortality Vital Statistics; NIX Gene; Nature; Non-Coding; Non-Coding RNA; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Outcome; Ovarian; Oxygen Deficiency; P53; Pathway interactions; Phase; Play; Prevention strategy; Preventive strategy; Proteins; Reporting; Research Specimen; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Surface; TP53; TP53 gene; TRP53; Testing; Tetracycline Antibiotic; Tetracyclines; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transforming Genes; Transgenic Mice; Transplantation, Heterologous; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Woman; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; biological signal transduction; cancer progression; career development; cell growth; clinical investigation; disease/disorder; gene product; genetic disorder; hereditary disorder; in vivo; inhibitor; inhibitor/antagonist; malignancy; malignant breast neoplasm; mammary; mammary tumor; miRNA; migration; model organism; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new approaches; new diagnostics; new therapeutic target; next generation diagnostics; novel; novel approaches; novel diagnostics; novel strategies; novel strategy; oncosuppressor gene; ovarian cancer; overexpression; pathway; pre-clinical; preclinical; prevent; preventing; public health relevance; social role; tumor; tumor growth; tumor progression; tumor xenograft; tumorigenesis","The role of microRNA, mir-30d, in the initiation and progression of cancer"," Project Narrative Ovarian and breast cancers are the most important causes of cancer-related mortality in women. microRNAs are small non-coding RNAs, which regulate gene expression in a sequence-specific manner. We will conduct a detailed study of mir-30d in ovarian and breast cancer with the intent to (i) learn important lessons in ovarian and breast cancer biology; (ii) discover novel therapeutic target.",142776,MONC,Molecular Oncogenesis Study Section,A1,1,331309,
7766688,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA142780-01,,NCI:360359;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"PANDOLFI, PIER PAOLO ;",1881582;,1R01CA142780,02/01/2010,01/31/2015,"Abnormal Assessment of Metabolism; Acute; Address; Adverse effects; Affect; Anti-Oncogenes; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Antioncogenes; Apoptosis; Apoptosis Pathway; Autoregulation; Biological; Blood; Cancer Genes; Cancer of Prostate; Cancer-Promoting Gene; Cancers; Catabolism; Caucasian; Caucasian Race; Caucasoid; Caucasoid Race; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cytoplasm; D-Glucose; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Dextrose; Diabetes Mellitus; Diet; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disorder; EC 2.7; Embryo; Embryonic; Emerogenes; Energy-Generating Resources; Epidemic; Event; Fasting; Fatty Acid Metabolism Pathway; Fatty Acids; Fibroblasts; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic; Glucose; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Homeostasis; Human; Human Cell Line; Human, General; Imidodicarbonimidic diamide, N,N-dimethyl-; Incidence; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; Kinases; Knockout Mice; LKB1; LKB1/STK11 Gene; Lipids; Liver Cells; Lymphocytes, Null; METBL; MYL; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Metabolic Processes; Metabolic Studies; Metabolic syndrome; Metabolism; Metabolism Studies; Metformin; Mice; Mice, Knock-out; Mice, Knockout; Modification; Molecular; Murine; Mus; Nucleus; Null Cells; Null Lymphocytes; Null Mouse; Nutrient; Obesity; Occidental; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P53; PJS; PML gene; Pathogenesis; Pathway interactions; Patients; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiological Homeostasis; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Predisposition; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Regulation; Research Specimen; Reticuloendothelial System, Blood; Role; STK11; STK11 gene; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solid; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stress; Subcellular Process; Susceptibility; Syndrome; TP53; TP53 gene; TRIM19; TRP53; Testing; Therapeutic; Thesaurismosis; Transforming Genes; Transphosphorylases; Treatment Side Effects; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Genes; Tumor Suppressor Proteins; adiposity; anti-diabetic drugs; anticancer activity; antidiabetic; base; biological signal transduction; cancer risk; clinical data repository; clinical data warehouse; corpulence; corpulency; corpulentia; data repository; deprivation; diabetes; diabetic; diabetic patient; disease/disorder; energy source; fasted; fasts; fatty acid metabolism; fatty acid oxidation; gene product; glucose metabolism; in vivo; interest; malignancy; metabolic abnormality assessment; metabolism disorder; mouse model; mutant; neoplasm/cancer; novel; obese; obese people; obese person; obese population; oncosuppressor gene; pathway; programs; public health relevance; relational database; respiratory; response; senescence; side effect; social role; therapy adverse effect; treatment adverse effect; tumor; tumor suppressor; tumor xenograft; tumorigenesis; white race",A metabolic role for PML in tumor suppression," Narrative Cancer, diabetes and obesity are by now epidemic disorders in the occidental world. Their development is intertwined because molecular pathways that are involved in the genesis of these metabolic disorders have been also implicated in cancer development. Exciting preliminary findings indicate that the PML tumor suppressor opposes cancer but also these metabolic syndromes. This proposal outlines an experimental program to study this novel function of PML with important therapeutic implications.",142780,TCB,Tumor Cell Biology Study Section,,1,360359,
7766562,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA142805-01,,NCI:358877;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"LEE, SAM W;",1905918;,1R01CA142805,02/01/2010,01/31/2015,"(SP-4-2)-Diamminedichloroplatinum; A549; Active Oxygen; Address; Adverse effects; Affinity Chromatography; Antioncogene Protein p53; Antioxidants; Anzatax; Apoptosis; Apoptosis Pathway; Apoptotic; Asotax; Biochemical; Bladder; Body Tissues; Breast; Breast Cancer Model; Breast Neoplasms; Breast Tumors; Bristaxol; CDDP; Cancer Cell Growth; Cancer Radiotherapy; Cancer Treatment; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cells; Cellular Tumor Antigen P53; Cessation of life; Characteristics; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Chromatography, Affinity; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical; Collaborations; Combination Chemotherapy Regimen; Combined Modality Therapy; Crossmatching, Tissue; Cysplatyna; Cytotoxic Chemotherapy; Cytotoxic Therapy; Cytotoxic agent; Cytotoxic drug; DDP; DNA Damage; DNA Injury; Death; Development; Dichlorodiammineplatinum; Dose; Drug Design; Drug Discovery Groups; Drug resistance; Drugs; Electromagnetic Radiation, Ionizing; Gene Transcription; Generations; Genes, p53; Genetic Transcription; Genotoxic Stress; Goals; Histocompatibility Testing; Human; Human, General; In Vitro; Institutes; Intracellular Communication and Signaling; Ionizing radiation; JNK; JNK1; JNK1A2; JNK21B1/2; Killings; Left; Lung; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Malignant Cell; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medication; Mice; Mice, Transgenic; Mind; Molecular; Molecular Target; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Names; Normal Cell; Normal Tissue; Normal tissue morphology; Noxae; Oncoprotein p53; Organ; Oxidative Stress; Oxidative Stress Induction; Oxygen Radicals; P53; PRKM8; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Photometry/Spectrum Analysis, Mass; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Praxel; Pro-Oxidants; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein TP53; Protein p53; Quimioterapia; RNA Expression; Radiation therapy; Radiation-Ionizing Total; Radio; Radiotherapeutics; Radiotherapy; Reactive Oxygen Species; Research; Resistance; Respiratory System, Lung; Role; SAPK1; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stress, Genotoxic; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Therapeutic; Tissue Crossmatchings; Tissue Typing; Tissues; Transcription; Transcription, Genetic; Transgenic Mice; Treatment Efficacy; Treatment Side Effects; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumorigenicity; Urinary System, Bladder; abstracting; affinity purification; anti-oxidant; anticancer therapy; base; biological signal transduction; cancer cell; cancer chemotherapy; cancer therapy; cell type; chemical genetics; chemotherapeutic agent; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; combination therapy; combined modality treatment; combined treatment; cytotoxic; design; designing; drug discovery; drug resistant; drug/agent; experiment; experimental research; experimental study; histocompatibility typing; in vivo; insight; interest; irradiation; malignancy; mammary cancer model; mammary tumor; mammary tumor model; melanoma; mouse model; multimodality therapy; necrocytosis; neoplasm/cancer; neoplastic cell; novel; nutlin 3; p53 Antigen; p53 Tumor Suppressor; pathway; pre-clinical; preclinical; public health relevance; pulmonary; research study; resistance to Drug; resistant; resistant to Drug; response; side effect; small molecule; social role; therapeutic efficacy; therapeutically effective; therapy adverse effect; treatment adverse effect; tumor; tumor growth; tumor xenograft; urinary bladder",Targeting ROS by a p53-activating agent for selective killing of cancer cells," Project Narrative In cancer chemotherapy, selectivity remains a great concern because DNA damaging drugs kill both cancer cells and the surrounding normal cells, which is an important cause of side effects during cancer chemotherapy. The goal of this application is to understand the underlying mechanisms for the unusual cancer specific selective effect of a newly identified p53 activator.",142805,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,1,358877,
7768872,R01,CA,1,,01/18/2010,12/31/2010,PA-07-070,1R01CA142824-01,,NCI:405051;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,BIOMEDICAL ENGINEERING,04,044387793,US,NC,27705,DUKE UNIVERSITY,"NIGHTINGALE, KATHRYN RADABAUGH;",1864423;,1R01CA142824,01/18/2010,12/31/2014,"Acoustic; Acoustics; Adenocarcinoma; Adenoma, Malignant; Algorithms; Ally; Benign; Benign Prostatic Hypertrophy; Biopsy; Biopsy, Core Needle; Body Tissues; Breast; Cancer Detection; Cancer Radiotherapy; Cancer of Prostate; Cancers; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cessation of life; Characteristics; Clinical; Cold Therapy; Core Biopsy; Coupled; Cryotherapy; Cutaneous; DRE; Data; Death; Detection; Development; Diagnosis; Diagnosis, Ultrasound; Digital Rectal Examination; Disease; Disorder; EC 3.4.21.34; Echography; Echotomography; Elasticity; Europe; Fletcher Factor; Generalized Growth; Genital System, Male, Prostate; Gleason Grade; Gleason Grade for Prostate Cancer; Gleason Score; Gleason Score for Prostate Cancer; Gleason Sum; Gleason-SC; Goals; Growth; Hand; Head and Neck, Thyroid; Heating; Histologic; Histologic Grade; Histologically; Histology; Histopathologic Grade; Human Prostate; Human Prostate Gland; INFLM; Image; Imagery; In Situ; Inflammation; Investigation; KLK3; Kallikrein 3; Laboratories; Lesion; Liver; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Measures; Medical Imaging, Ultrasound; Methods; Monitor; Needles; Newly Diagnosed; Organ System, Cardiovascular; P-30 Antigen; Pathologic; Pathology; Patient observation; Pattern; Physiologic pulse; Plasma Kallikrein Precursor; Plasma Prekallikrein; Procedures; Process; Prostate; Prostate CA; Prostate CA therapy; Prostate Cancer; Prostate Cancer therapy; Prostate Gland; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostatic; Prostatic Cancer; Prostatic Gland; Prostatic Hyperplasia, Benign; Prostatic Hypertrophy, Benign; Prostatovesiculectomy; Pulse; Radiation; Radiation therapy; Radical Prostatectomy; Radiotherapeutics; Radiotherapy; Recurrence; Recurrent; Reporting; Research; Research Specimen; Resolution; Sampling; Screening procedure; Semenogelase; Seminin; Specimen; Staging; Stress; Structure; System; System, LOINC Axis 4; Therapeutic Cold; Thyroid; Thyroid Gland; Time; Tissue Growth; Tissues; Transducers; Tumor Tissue; Ultrasonic; Ultrasonic Diagnosis; Ultrasonic Imaging; Ultrasonic Transducer; Ultrasonics; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound transducer; Ultrasound, Medical; United States; Universities; Vascular, Heart; Visualization; Watchful Waiting; Work; base; benign prostate hyperplasia; body system, hepatic; cancer recurrence; circulatory system; clinical applicability; clinical application; clinical significance; clinically significant; cohort; density; design; designing; diagnostic ultrasound; disease/disorder; gamma-Seminoprotein; hK3 Kallikrein; imaging; imaging modality; improved; in vivo; irradiation; kininogenin; malignancy; men; men's; neoplasm/cancer; ontogeny; organ system, hepatic; public health relevance; ray (radiation); response; screening; screenings; sonogram; sonography; sound measurement; standard of care; tumor; ultrasound; ultrasound imaging; ultrasound scanning",Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures," Relevance: Prostate cancer (PCa) is the most common non-cutaneous cancer in men in the United States, with over 185,000 cases newly diagnosed, and over 28,000 deaths annually [1]; PCa is currently diagnosed by ultrasonic guided biopsy in which systematic sampling of the prostate is performed because PCa is not gener- ally visualized in ultrasonic images, thus, PCa biopsy is reported to have poor sensitivity (53%)[5]. We propose to develop ultrasonic radiation force based stiffness imaging methods capable of visualizing focal can- cers in the prostate, thus providing targeting for biopsy procedures. If successful, this research has the potential to greatly improve the cancer detection yield for clinically significant grade cancers on first time biopsies, to reduce the number of biopsy cores taken during biopsy, to facilitate longitudinal monitoring of PCa growth or recurrence after in situ therapies, and to provide image guidance for focal PCa therapies.",142824,BMIT,Biomedical Imaging Technology Study Section,,1,405051,
7768562,R01,CA,1,,01/20/2010,12/31/2010,PA-07-070,1R01CA143032-01,,NCI:633103;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"MELNICK, ARI M.;",1976585;,1R01CA143032,01/20/2010,12/31/2014,"Affinity; Animals; Antibody Formation; Antibody Production; Antibody Response; B blood cells; B lymphoma; B-Cell CLL/Lymphoma-6 Gene; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; BCL5; BCL6; BCL6 gene; BTB Domain; BTB/POZ Domain; Binding; Binding (Molecular Function); Biological; Biology; Brill-Symmers Disease; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Genes; Cancer-Promoting Gene; Cancers; Cell Death; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Clinic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Complex; Cys-His2 Zinc Finger Transcription Factor Gene; DLBCL; DNA Damage; DNA Injury; Data; Development; Diffuse Large B-Cell Lymphoma; Diffuse non-Hodgkin's lymphoma, large cell; Docking; Dose; Drug Design; Drug Kinetics; Drug usage; Drugs; Family; Follicle Center Lymphoma; Follicular Lymphoma; Follicular Non-Hodgkin's Lymphoma; Funding; Gene Inactivation; Gene Silencing; Gene Targeting; Genes, Regulator; Genes, p53; Germinal Center; Germinoblastoma; Goals; Hematopathology; Human; Human, General; In Vitro; KIAA1047; Killings; LAZ-3 Gene; LAZ3; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Follicular; Lymphoma, Giant Follicular; Lymphoma, Malignant; Lymphoma, Nodular; Lymphoma-Associated Zinc Finger Gene on Chromosome 3; Macromolecular Structure; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Molecular Interaction; Molecular Structure; Molecular Target; Murine; Mus; N-CoR; N-CoR1; N-terminal; NCOR1; NCOR1 protein, human; NH2-terminal; Normal Cell; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Corepressor; Oncogenes; P53; POZ Domain; Pathway interactions; Patients; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phase 2 Clinical Trials; Phase II Clinical Trials; Protein Family; Proteins; Regulator Genes; Repression; Repressor Proteins; Research Specimen; Reticulolymphosarcoma; Safety; Sarcoma, Germinoblastic; Scientist; Specimen; Structure of germinal center of lymph node; Surface; TP53; TP53 gene; TRAC1; TRP53; Targetings, Gene; Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1; Toxic effect; Toxicities; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Regulatory Elements; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transforming Genes; Translating; Translatings; Tumor Protein p53 Gene; United States; Work; ZNF51; ZNF51 Gene; Zinc Finger Protein 51 Gene; antibody biosynthesis; biomarker; cell killing; clinical care; clinical investigation; cultured cell line; design; designing; disease subtype; disorder subtype; drug use; drug/agent; experience; gene product; hCIT529I10; hN-CoR; human NCOR1 protein; immunoglobulin biosynthesis; improved; in vivo; inhibitor; inhibitor/antagonist; language translation; large cell Diffuse non-Hodgkin's lymphoma; malignancy; member; mimetics; necrocytosis; neoplasm/cancer; pathway; peptidomimetics; phase 2 study; phase 2 trial; phase II trial; protein protein interaction; protocol, phase II; public health relevance; regulatory gene; response; study, phase II; therapeutic target; trans acting element; tumor",Molecular Targeting of Diffuse Large B-cell Lymphoma," Project Narrative B-cell lymphomas are the fourth most common form of cancer in the United States and several subtypes of this disease are incurable. The most common causative oncogene in these tumors is the BCL6 transcriptional repressor protein. This proposal will define the mechanism of action, refine and translate to a clinical trial a specific BCL6 targeted therapy peptidomimetic drug that we predict will have a major impact on improving the clinical care for patients with B-cell lymphomas.",143032,DMP,Drug Discovery and Molecular Pharmacology Study Section,,1,633103,
7768941,R01,CA,1,,01/01/2010,12/31/2010,PA-07-070,1R01CA143167-01,,NCI:355729;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,,00,143983562,US,DC,20010,CHILDREN'S RESEARCH INSTITUTE,"HILL, DANA ASHLEY;",8313428;,1R01CA143167,01/01/2010,12/31/2014,"0-11 years old; 1 year old; 14q31; 6 year old; Address; Affect; Alleles; Allelomorphs; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Autoimmune; Autoimmune Process; Body Tissues; Cancer Family; Cancers; Candidate Disease Gene; Candidate Gene; Caring; Cell Function; Cell Process; Cell Transformation, Neoplastic; Cell physiology; Cell/Tissue, Immunohistochemistry; Cells; Cellular Function; Cellular Physiology; Cellular Process; Child; Child Youth; Childhood Neoplasm; Childhood Tumor; Children (0-21); Chromosomes; Cleaved cell; Clinical; Connective Tissue Sarcoma; Consent; Counseling; Cyst; Cyst, Pilar; DCR-1 Homolog Gene; DICER Gene; DICER1; DICER1 gene; DROSHA; Data; Defect; Detection; Development; Disease; Disorder; Early Diagnosis; Embryo; Embryonic; Endoribonuclease Dicer Gene; Epidemiology, Family Medical History; Epidemiology, Personal Medical History; Epidermal Cyst; Epidermal Inclusion Cyst; Epidermoid Cyst; Epithelial; Epithelial cyst; Epithelium; Evaluation; Expression Profiling; Expression Signature; Extended Family; Familial disease; Family; Family Medical History; Family Study; Family history of; Family member; Family, Extended; Fetal Lung; Foundations; Frequencies (time pattern); Frequency; Future; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Heterogeneity; Genetic defect; Germ-Line Mutation; Germline Mutation; HERNA Gene; HSA242976; Helicase with RNase Motif Gene; Helicase-MOI Gene; Hereditary; Hereditary Mutation; Heritability; History; Homolog of Drosophila Dicer Gene; Horn Cyst; Human; Human, Child; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Inclusion Cyst; Individual; Inherited; Investigation; K12H4.8-Like Gene; Keratin Cyst; Keratinizing Cyst; Keratinous Cyst; Knock-out; Knockout; Lead; Learning; Light; Linkage Analysis; Lung; Malignant Neoplasms; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Soft Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measures; Medical; Medical History; Medical Records; Mesenchymal; Mesenchymas; Mesenchyme; Mice; Micro RNA; MicroRNAs; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutation; Mutation Analysis; Neoplasms; Neoplastic Cell Transformation; Nephroblastoma; Nuclear RNase III Drosha; Oncogenesis; Parents; Pathogenesis; Pathway interactions; Patients; Pb element; Pediatric Neoplasm; Pediatric Tumor; Penetrance; Personal Medical History; Phenotype; Photoradiation; Play; Pleuropulmonary Blastoma; Predisposition; Pregnancy Histories; Processed Genes; Proteins; Pulmonary Sarcoma; Questionnaire Designs; RN3; RNASE3L; RNASE3L gene; RNase D; RNase III; RNase III Gene; RNase O; Recording of previous events; Renal Wilms' Tumor; Research; Respiratory System, Lung; Rhabdomyosarcoma; Ribonuclease D; Ribonuclease III; Risk; Role; Sarcoma of the Soft Tissue and Bone; Sarcoma, Soft Tissue; Science of Anatomy; Screening procedure; Sebaceous Cyst; Siblings; Solid; Somatic Mutation; Staging; Subcellular Process; Susceptibility; Syndrome; Testing; Tissues; Tumors; Wilm's Tumor; Wilms Tumor; Wilms' Tumor of the Kidney; Work; anatomy; base; children; cleaved; cohort; disease/disorder; early detection; experiment; experimental research; experimental study; exportin 5; familial disorder; family based linkage study; gene product; genetic linkage analyses; genetic linkage analysis; genome mutation; grandparent; heavy metal Pb; heavy metal lead; human disease; knowledge base; linkage analyses; loss of function; lung development; lung sarcoma; malignancy; member; miRNA; model organism; molecuar profile; molecular signature; neoplasia; neoplasm/cancer; neoplastic; neoplastic growth; neoplastic transformation; novel; one year old; p241; pathway; pre-miRNA; proband; public health relevance; pulmonary; research study; sarcoma; screening; screenings; six year old; social role; tumor; tumor initiation; tumorigenesis; youngster",DICER1 and the Pleuropulmonary Blastoma Family Cancer Syndrome, This work will shed light on the role genetics plays in a new pediatric tumor syndrome and could ultimately lead to new strategies to the detection and treatment of PPB and related tumors such as rhabdomyosarcoma and Wilms tumor.,143167,CG,Cancer Genetics Study Section,,1,355729,
7769987,R01,CA,1,,02/01/2010,01/31/2011,PA-08-243,1R01CA143204-01,,NCI:334695;,2010,NATIONAL CANCER INSTITUTE,,PISCATAWAY,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"FENG, ZHAOHUI ;",9759503;,1R01CA143204,02/01/2010,11/30/2014,"Accounting; Allelic Loss; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; Assay; Athymic Nude Mouse; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Breast Cell Glutaminase; Cancer Treatment; Carcinoma Cell; Carcinoma of the Liver Cells; Causality; Cell Cycle Arrest; Cell Death, Programmed; Cells; Cellular Regulation; Cellular Tumor Antigen P53; Code; Coding System; DNA Alteration; DNA mutation; Data; Detection; Development; Diagnosis; EC 3.5.1.2; Early Diagnosis; Energy Expenditure; Energy Metabolism; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Etiology; Event; GA Protein; GLS2; Gene Alteration; Gene Mutation; Gene Products, RNA; Gene Targeting; Genes; Genes, p53; Genetic; Genetic mutation; Glutaminase; Glycolysis; HCC; Hepatic Cancer; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Heterograft; Human; Human, General; Hypermethylation; Intermediary Metabolism; L glutamine amidohydrolase; Lead; Link; Liver; Liver Glutaminase; Loss of Heterozygosity; METBL; Malignant; Malignant - descriptor; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant neoplasm of liver; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Processes; Metabolism; Mice, Athymic; Mice, Nude; Mitochondria; Modeling; Molecular; Mortality; Mortality Vital Statistics; Nude Mice; Oncogenesis; Oncoprotein p53; P53; Pb element; Phosphoprotein P53; Phosphoprotein pp53; Play; Prevention; Primary carcinoma of the liver cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein TP53; Protein p53; Proteins; RNA; RNA, Non-Polyadenylated; Radiation; Regulation; Research Specimen; Residual; Residual state; Respiration; Ribonucleic Acid; Role; Sampling; Sequence Alteration; Series; Specimen; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Tet; Tetanus Helper Peptide; Therapeutic; Tissues; Transfection; Transplantation, Heterologous; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; United States; Warburg Effect; Xenograft; Xenograft procedure; Xenotransplantation; anticancer therapy; base; biological adaptation to stress; biomarker; body system, hepatic; cancer therapy; cancer type; cell growth regulation; chemotherapeutic agent; disease causation; disease etiology; disease/disorder etiology; disorder etiology; early detection; effective therapy; expression vector; gene product; heavy metal Pb; heavy metal lead; in vivo; knock-down; liver cancer; mRNA Expression; malignant liver tumor; mitochondrial; mouse model; mutant; neoplastic cell; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; organ system, hepatic; p53 Antigen; p53 Tumor Suppressor; prevent; preventing; public health relevance; ray (radiation); reaction; crisis; respiratory mechanism; response; restoration; senescence; shRNA; short hairpin RNA; small hairpin RNA; social role; stress response; stress; reaction; therapeutic target; tumor; tumor initiation; tumorigenesis; vector","The role of glutaminase 2, a novel p53 target gene in metabolism, in liver cancer"," In this proposed study we will study the role and mechanisms of GLS2 gene in tumor suppression. This study will greatly increase our understanding of the molecular mechanisms for tumorigenesis, especially the role of metabolic changes in tumor initiation and progression. This study will have direct potential to provide GLS2 as a novel tumor biomarker for tumor diagnosis and therapeutic target for tumor therapy, especially for liver cancer.",143204,CG,Cancer Genetics Study Section,,1,334695,
7776810,R01,CA,1,,01/25/2010,12/31/2010,PA-07-070,1R01CA143811-01,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"WALKER, CHERYL L;",1864344;,1R01CA143811,01/25/2010,12/31/2014,"AKT; ATM activation; Active Oxygen; Akt protein; Apoptosis; Apoptosis Pathway; Attention; Autophagocytosis; Autophagosome; Autoregulation; Cancer Induction; Cancer Treatment; Carrier Proteins; Catabolism; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Chemical Fractionation; Clofibrate; Clofibric Acid, Ethyl Ester; Complex; Confocal Microscopy; Data; Development; EC 2.7; Ethyl Chlorophenoxyisobutyrate; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRACN; FRAP1 protein, human; Fractionation; Fractionation Radiotherapy; Future; Gatekeeping; Generations; Hepatocarcinogenesis; Homeostasis; Imagery; Intracellular Communication and Signaling; KIAA0243; Kinases; Knockout Mice; LKB1; LKB1/STK11 Gene; Liver Carcinogenesis; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mediating; Membrane; Mice, Knock-out; Mice, Knockout; Microscopy, Confocal; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Null Mouse; Organelles; Oxidation-Reduction; Oxidative Stress; Oxygen Radicals; PJS; PKB protein; Pathway interactions; Peptide Biosynthesis, Ribosomal; Peroxisome Proliferators; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Play; Prevention strategy; Preventive strategy; Pro-Oxidants; Process; Production; Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase B; Protein Synthesis, Ribosomal; Proteins; Proto-Oncogene Proteins c-akt; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Ras homolog enriched in brain; Reactive Oxygen Species; Receptor Protein; Redox; Regulation; Repression; Role; STK11; STK11 gene; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small G-Proteins; Small GTPases; Subcellular Process; TSC1; TSC1 gene; Testing; Therapeutic; Time; Transphosphorylases; Transport Proteins; Transporter Protein; Tsc1 [{C0694894}]; Tuberous sclerosis protein complex; Tumor Cell; Tumor Suppressor Proteins; Visualization; activation, Atm; anticancer therapy; autophagy; biological adaptation to stress; biological signal transduction; c-akt protein; cancer therapy; carcinogenesis; carcinogenesis in the liver; cell growth; design; designing; experiment; experimental research; experimental study; fatty acid oxidation; gatekeeper; gene product; hepatocellular carcinogenesis; human FRAP1 protein; in vivo; liver cancer pathogenesis; mTOR; membrane structure; mutant; neoplastic cell; novel; oxidation reduction reaction; pathway; peroxisome; protein synthesis; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; reaction; crisis; receptor; related to A and C-protein; research study; response; sensor; social role; stress response; stress; reaction; tuberous sclerosis complex; tumor suppressor",TSC2 Localization and Function at the Peroxisome," Project Narrative The overarching hypothesis of this proposal is that TSC2 participates in a novel stress response pathway at the peroxisome to repress mTOR signaling and regulate cellular autophagy. Understanding the mechanisms that regulate the process of autophagy or influence the cell's decision to initiate this process has important implications for carcinogenesis and cancer therapy. A better understanding of the mechanisms that control this process has the potential to aid in the design of prevention strategies targeting the peroxisome and signaling pathways that localize to this organelle. In addition, in the future they may aid in the design of therapeutics that limit the ability of tumor cells to utilize autophagy as a survival pathway and/or promote autophagy-induced programmed cell death in response to therapy.",143811,CSRS,Cellular Signaling and Regulatory Systems Study Section,,1,319550,
7789956,R01,CA,1,,01/15/2010,12/31/2010,PA-07-070,1R01CA144034-01,,NCI:1546796;,2010,NATIONAL CANCER INSTITUTE,,MINNEAPOLIS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"YUAN, JIAN-MIN ;",7997357;,1R01CA144034,01/15/2010,12/31/2014,"2,4(1H,3H)-pyrimidinedione; 2,4-dioxopyrimidine; 2,4-pyrimidinediol; 2-Hydroxy-N,N,N-trimethylethanaminium; 2-Propenal; 2-amino-4-mercaptobutyric acid; 2-hydroxy-4-(3H)-pyrimidione; 4-hydroxy-2-(1H)-pyrimidione; Acetylcysteine; Acetylin; Acraldehyde; Acrolein; Acrylaldehyde; Acrylic Aldehyde; Active Follow-up; Age-Years; Airbron; Allen & Hanburys Brand of Acetylcysteine; Allyl Aldehyde; Applications Grants; Aromatic Polycyclic Hydrocarbons; Benzene; Benzol; Benzole; Biochemical Markers; Blood; Blood Serum; Bristol-Myers Squibb Brand of Acetylcysteine; Bristol-Myers Squibb Brand of Acetylcysteine Sodium Salt; Broncholysin; Brunac; Butadiene; Butanoic acid, 4,4'-dithiobis(2-amino)-; Cancer Cause; Cancer Etiology; Cancer of Lung; Cancers; Carcinoma of the Liver Cells; Cessation of life; Chinese; Chinese People; Choline; Clinical Treatment; Cohort Studies; Collection; Concurrent Studies; Consent; Cyclohexatriene; DNA; DNA Methylation; DNA Modification Methylases; DNA Modification Methyltransferases; DNA-Methyltransferases; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Deoxyribonucleic Acid; Development; Diagnostic; Dnmt; EC 2.1.1.113; Early Diagnosis; Enrollment; Environmental Exposure; Environmental Factor; Environmental Risk Factor; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethylene Aldehyde; Ethylene Oxide; Fabrol; Fluatox; Fluimucetin; Fluimucil; Fluprowit; Folate; Funding; Genetic; Genetic Markers; Genetic Polymorphism; Goals; Grant Proposals; Grants, Applications; HCC; Health; Hepatic Cancer; Hepatocarcinogenesis; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Homocysteine; Homocysteine, L-Isomer; Homocystine; Human; Human, General; Incidence; Individual; Inpharzam Brand of Acetylcysteine; Intermediary Metabolism; Interview; Investigation; Investigators; Knowledge; L-Alpha-acetamido-beta-mercaptopropionic Acid; L-Methionine; Lead; Life Style; Lifestyle; Liver Carcinogenesis; Lung; METBL; MTHFR; MTHFR gene; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of liver; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Markers, Biochemical; Measures; Mercapturic Acid; Metabolic Processes; Metabolism; Methionine; Methionine, L-Isomer; Modification Methylases; Mortality; Mortality Vital Statistics; Muco Sanigen; Mucocedyl; Mucolator; Mucolyticum; Mucomyst; Mucosolvin; Mucret; N-Acetyl Cysteine; N-Acetyl-L-cysteine; N-Acetylcysteine; N-acetyl-3-mercaptoalanine; NAC; NAC Zambon; NCI; NCI Organization; National Cancer Institute; Neo-Fluimucil; Nested Case-Control Study; Non-smoker; Optipect Hustengetr??nk; Oxirane; PAH; Participant; Parvolex; Pathway interactions; Pb element; Peer Review; Persons; Polycyclic Hydrocarbons, Aromatic; Polymorphism (Genetics); Polymorphism, Genetic; Polynuclear Aromatic Hydrocarbons; Predisposition; Prevention; Preventive; Primary carcinoma of the liver cells; Procedures; Produpharm Lappe Brand of Acetylcysteine; Prospective Studies; Publishing; Pulmonary Cancer; Pulmonary malignant Neoplasm; Pyridoxine (Vitamin B6); R01 Mechanism; R01 Program; RPG; Repetitive Element; Repetitive Regions; Repetitive Sequence; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Respaire; Respiratory System, Lung; Reticuloendothelial System, Blood; Retirement; Risk; Roberts Brand of Acetylcysteine; Role; Sample Size; Sampling; Screening procedure; Series; Serum; Singapore; Site-Specific DNA-methyltransferase; Smoker; Study Type; Study, Nested Case-Control; Sum; Susceptibility; TYMS; TYMS gene; Thiemann Brand of Acetylcysteine; Thymidylate Synthase Gene; Tixair; UPSA Brand of Acetylcysteine; Uracil; Urinary System, Urine; Urine; VIT B6; Variant; Variation; Vitamin B 6; Vitamin B6; Woman; Zambon Brand of Acetylcysteine; Zyma Brand of Acetylcysteine; acryaldehyde; base; biomarker; cancer risk; carcinogenesis in the liver; clinical data repository; clinical data warehouse; cohort; cold temperature; cost; data repository; early detection; enroll; environment effect on gene; environmental risk; experiment; experimental research; experimental study; follow-up; gene environment interaction; genetic variant; heavy metal Pb; heavy metal lead; hepatocellular carcinogenesis; high risk; insight; liver cancer; liver cancer pathogenesis; low temperature; lung cancer; lung development; malignancy; malignant liver tumor; member; men; men's; methyl group; mid life; mid-life; middle age; middle aged; midlife; neoplasm/cancer; nonsmoker; novel; pathway; polymorphism; polynuclear aromatic hydrocarbon; public health relevance; pulmonary; relational database; research study; screening; screenings; social role; study design; trait; trial regimen; trial treatment; uptake",Prospective studies of cancer etiology and prevention in Shanghai and Singapore," The Shanghai and Singapore cohort studies are ongoing observational follow-up investigation of environmental and genetic factors on human cancers in 81,501 middle-aged and older Chinese men and women beginning in 1986 and 1993, respectively. The proposed studies within these two cohort will identify a set of non-invasive, predictive markers of lung and liver cancer development. People with high risk could take primary preventive measures to reduce their risk, or undergo regular screening for early detection of the malignancies when clinical treatment is more effective. The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans.",144034,ZRG1,Special Emphasis Panel,,1,1546796,
7862092,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA149253-01,,NCI:234465;,2010,NATIONAL CANCER INSTITUTE,,PORTLAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"QIAN, ZHENG DAVID ;",8641674;,1R01CA149253,02/01/2010,01/31/2015,"Acetylation; Animal Model; Animal Models and Related Studies; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Biological; Cancer Drug; Cancer Patient; Cancer cell line; Cancers; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Coupled; Development; Disease; Disorder; Family; Generalized Growth; Goals; Grant; Growth; HA6116; HD1; HD4; HDAC; HDAC Agent; HDAC Proteins; HDAC-A; HDAC1; HDAC1 gene; HDAC1 protein, human; HDAC3; HDAC3 enzyme; HDAC4; HDAC4 gene; HDACA; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Heterograft; Histone Deacetylase; Histone Deacetylase 1; Histone Deacetylase Inhibitor; Histone deacetylase inhibition; Human; Human, General; In Vitro; Isoenzymes; Isozymes; KIAA0288; Knowledge; L-Lysine; Lead; Lysine; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Molecular Target; N-terminal; NH2-terminal; Oncogenesis; Patients; Pb element; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; RPD3; RPD3L1; RPD3L1 protein, human; Reporting; Site; Testing; Therapeutic; Tissue Growth; Toxic effect; Toxicities; Transplantation, Heterologous; Treatment outcome; Tumor-Specific Treatment Agents; Xenograft; Xenograft procedure; Xenotransplantation; angiogenesis; anticancer agent; anticancer drug; base; clinical investigation; design; designing; disease/disorder; erythrocyte histone deacetylase 1, human; gene product; heavy metal Pb; heavy metal lead; histone deacetylase 3; human HDAC1 protein; hypoxia inducible factor 1; improved; in vivo; malignancy; member; model organism; mutant; neoplasm/cancer; new approaches; next generation; novel; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; prevent; preventing; protein degradation; public health relevance; shRNA; short hairpin RNA; small hairpin RNA; tumor growth; tumorigenesis",HIF1a N-terminus hyperacetylation and anticancer mechanism of hydroxamic-HDACi, The knowledge gained from this grant will help us to use the current cancer therapeutics more effectively and appropriately to treat cancer patients. It will also guide us to design and discover the next generation of anticancer drugs.,149253,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,1,234465,
7865790,R01,CA,1,,02/01/2010,01/31/2011,PA-07-070,1R01CA149614-01,,NCI:325010;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"OLSEN, MARGARET A;",2072025;,1R01CA149614,02/01/2010,01/31/2015,"Abscission; Accounting; Adjuvant Radiotherapy; Algorithms; Autologous; Axillary Lymph Node Dissection; Body Image; Body Tissues; Breast; Breast Implants; Breast Prosthesis, Internal; Breast Reconstruction; Cancer Patient; Cancer Radiotherapy; Cancer of Breast; Cancers; Carcinoma in Situ; Carcinoma, Intraepithelial; Carcinoma, Preinvasive; Caring; Clinical; Complication; Data; Diabetes Mellitus; Diagnosis; Emotional; Excision; Extirpation; Flaps; Healed; Health Insurance; Hematoma; History; Implant; Incidence; Individual; Infection; Institution; Insurance; Internal Breast Prosthesis; Island Flaps; Link; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammaplasty; Mammectomy; Mastectomy; Methods; Modeling; Multicenter Studies; Nature; Necrosis; Necrotic; Newly Diagnosed; Obesity; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Patient Preferences; Population; Preferences, Patient; Primary Neoplasm; Primary Tumor; Procedures; Process; QOL; Quality of life; Radiation therapy; Radiotherapeutics; Radiotherapy; Radiotherapy, Adjuvant; Reconstructive Surgical Procedures; Recording of previous events; Relative; Relative (related person); Removal; Reporting; Risk; Risk Factors; Seroma; Site; Staging; Stratification; Surgeon; Surgical; Surgical Flaps; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Time; Tissue Expanders; Tissues; Variant; Variation; Woman; adiposity; axillary dissection; base; breast surgery; cancer surgery; case finding; comparative; corpulence; corpulency; corpulentia; diabetes; healing; improved; in situ cancer; indexing; irradiation; malignancy; malignant breast neoplasm; neoplasm/cancer; obese; obese people; obese person; obese population; population based; psychosocial; public health relevance; randomized trial; reconstruction; reconstructive surgery; resection; surgery; tumor; wound",IMMEDIATE VS DELAYED RECONSTRUCTION AND BREAST CANCER SURGERY COMPLICATIONS, We propose to determine rates and risk factors for infectious and noninfectious wound complications after mastectomy with immediate compared to delayed breast reconstruction. We will develop an algorithm to predict wound complication rates. This study will provide important new information to determine the optimal timing and type of reconstructive surgery for women after mastectomy based on their underlying illnesses.,149614,NSAA,Nursing Science:  Adults and Older Adults Study Section,,1,325010,
7729355,R01,DA,1,,02/01/2010,01/31/2011,PA-07-070,1R01DA022451-01A2,,NIDA:181406;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LEXINGTON,UNITED STATES,PSYCHOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"AKINS, CHANA K.;",7880932;,1R01DA022451,02/01/2010,01/31/2015,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS Virus; Abuse, Cocaine; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Addiction, Drug; Animal Model; Animal Models and Related Studies; Animals; Association Learning; Behavior; Brain region; Breeding; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Chronic; Clinical; Clinical Research; Clinical Study; Cocaine; Cocaine Abuse; Conditioned Stimulus; Coturnix japonica; Cues; Dependence; Dependence, Drug; Dose; Drug Addiction; Drug Dependency; Drug Effects on Physiology; Drug abuse; Drug usage; Drugs; Effects, Longterm; Empirical Research; Ethics; Event; Extinction; Extinction (Psychology); Female; Food; Frequencies (time pattern); Frequency; Goals; HCV infection; HIV; HTLV-III; Health; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; High Prevalence; High-Risk Sex; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Intracellular Communication and Signaling; Investigation; K01 Award; K01 Mechanism; K01 Program; LAV-HTLV-III; Learning; Length; Light; Link; Long-Term Effects; Lymphadenopathy-Associated Virus; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Medication; Memory; Mentored Research Scientist Development Award; Mentored Training Award; Methods; Modeling; Motivation; Multiple Partners; NANBH; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Partner in relationship; Partners, Multiple; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Photoradiation; Physiological Effects of Drugs; Pre-Clinical Model; Preclinical Models; Procedures; Property; Property, LOINC Axis 2; Public Health; Publishing; Quail; Quails, Japanese; Recovery; Research; Research Scientist Development Award; Research Training; Resistance; Rewards; Rodent; Rodentia; Rodentias; STD; Saline; Saline Solution; Seasons; Sensory; Sex Behavior; Sexual Activity; Sexual Behavior; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Stimulus; System; System, LOINC Axis 4; Testing; Time; Translating; Translatings; Transmission; United States; Unprotected Sex; Unsafe Sex; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Visual; Withdrawal; Work; abuse of drugs; abused drugs; abuses drugs; addiction; approach behavior; behavior test; behavioral extinction; behavioral test; biological signal transduction; clinical relevance; clinically relevant; cocaine exposure; cocaine use; conditioning; drug detection; drug of abuse; drug testing; drug use; drug/agent; drugs abused; drugs of abuse; experience; experiment; experimental research; experimental study; hepatitis non A non B; hepatitis nonA nonB; high risk; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; indexing; language translation; male; mate; model organism; neural circuit; neural circuitry; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; preclinical study; public health medicine (field); public health relevance; research study; resistant; response; risky sexual behavior; sex; sex activity; transmission process",Enhancement of Sexual Motivation," Narrative Clinical studies have shown a correlation between cocaine use and risky sexual practices such as increased frequency, an increased number of partners, and unprotected sex. These sexual practices have been linked to adverse health consequences including high prevalence rates for sexually-transmitted diseases. The current application is a preclinical model used to investigate how drugs of abuse alter sexual motivation.",22451,ZRG1,Special Emphasis Panel,A2,1,181406,
7780482,R01,DA,1,,02/01/2010,11/30/2010,PA-07-329,1R01DA023996-01A1,,NIDA:344250;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MIAMI,UNITED STATES,PSYCHIATRY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"IZENWASSER, SARI ;",6619398;,1R01DA023996,02/01/2010,11/30/2014,"1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-; 12-20 years old; 21+ years old; 3,4 methylenedioxymethamphetamine; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; 5HT transporter; 5HTT protein; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abuse, Cocaine; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Age; Animals; Assay; Autoradiography; Behavior; Behavioral; Bioassay; Biologic Assays; Biological Assay; Cocaine; Cocaine Abuse; Common Rat Strains; Critical Period; Critical Period (Psychology); D2 receptor; DAT; DAT dopamine transporter; DRD2; DRD2 Receptor; Data; Development; Dopamine; Dopamine D2 Receptor; Drug abuse; Drug usage; Drugs; Drugs, Illicit; Ecstasy; Ecstasy - drug; Enteramine; Environment; Environmental Factor; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Exposure to; Female; Female Adolescents; Goals; Hippophaine; Housing; Human, Adult; Hydroxytyramine; Illicit Drugs; Incidence; Laboratory Study; Lead; Learning; Locomotor Activity; MDMA; Male Adolescents; Mammals, Rats; Measures; Mediating; Mediation; Medication; Methylenedioxymethamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Negotiating; Negotiation; Neurochemistry; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical environment; Play; Radioautography; Rat; Rat-1; Rat-1 Cells; Rattus; Receptor Protein; Research Design; Rewards; Role; Science of neurochemistry; Self Administration; Serotonin; Sex Characteristics; Sex Differences; Socialization; Socializations; Staging; Study Type; Substance abuse problem; Teen; Teenagers; Teens; Time; Toy; Translating; Translatings; abuse of drugs; abuse of substances; abused drugs; abuses drugs; adolescence (12-20); adolescent boy; adolescent drug use; adolescent girl; adult human (21+); cocaine use; critical developmental period; dopamine transporter; dopamine transporter proteins; drug of abuse; drug reward; drug use; drug/agent; drugs abused; drugs of abuse; ecstasy; environmental change; environmental risk; gender difference; heavy metal Pb; heavy metal lead; juvenile; juvenile human; language translation; male; neurochemistry; novel; preference; psychostimulant; psychostimulant abuse; public health relevance; receptor; receptor binding; response; serotonin transporter; sex; sexual dimorphism (noncellular); social; social role; sodium-dependent serotonin transporter; stimulant abuse; study design; substance abuse; teen years; teenage; uptake; youth drug use",Social and Environmental Factors in Adolescent Stimulant Abuse," It has been shown that teenagers who use MDMA (ecstasy) are more likely to use other drugs such as cocaine. The factors that contribute to this increased use are not completely known, however, it appears that several factors such as age, sex, socialization, and environment all play a role. Adolescents appear to be more vulnerable to the effects of drugs such as MDMA, and use during this time seems to sensitize them to the effects of other drugs of abuse. These studies are designed to study the role that these factors play in the effects that MDMA has and the effects of differences in social (housing) and environmental (availability of toys) will be studied on the effects of MDMA during adolescence in males and females. A better understanding of the specific effects of social and environmental factors on behaviors and neurochemistry altered by MDMA and cocaine in males and females during this important developmental period will lead to novel treatments and/or preventions for drug abuse.",23996,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",A1,1,344250,
7779690,R01,DA,1,,02/01/2010,01/31/2011,PA-07-070,1R01DA024746-01A2,,NIDA:377974;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,IRVINE,UNITED STATES,PHARMACOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"CIVELLI, OLIVIER ;",6529468;,1R01DA024746,02/01/2010,01/31/2014,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Addiction, Cocaine; Affect; Amphibia; Amphibians; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anti-Obesity Agents; Anti-Obesity Drugs; Antiobesity Agents; Antiobesity Drugs; Anxiolytic Agents; Anxiolytics; Area; Assay; Attention; Behavior; Bioassay; Biologic Assays; Biological Assay; Brain; Cells; Cocaine; Cocaine Dependences; Cues; DA melanin; Data; Dependences, Cocaine; Dopamine Receptor; Drug Design; Drug abuse; Eating; Encephalon; Encephalons; Exhibits; Expression Profiling; Expression Signature; Feeding behaviors; Fishes; Food; Food Intake; Genetics, in situ Hybridization; Hypothalamic structure; Hypothalamus; In Situ Hybridization; Ingestive Behavior; Knowledge; Lateral; Macromolecular Structure; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rodents; Mice; Mice, Obese; Molecular Fingerprinting; Molecular Profiling; Molecular Structure; Motivation; Mouse Strains; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptides; Nucleus Accumbens; Obese Mice; Peptides; Physiologic; Physiological; Property; Property, LOINC Axis 2; Psychological reinforcement; Receptor Protein; Reinforcement; Reinforcement (Psychology); Research; Rewards; Rodent; Rodentia; Rodentias; Role; Self Administration; Site; Skin; Structure of zona incerta; System; System, LOINC Axis 4; Testing; Tranquilizing Agents, Minor; Zona Incerta; abuse of drugs; abused drugs; abuses drugs; addiction; antianxiety agent; base; brain tissue; dopamine melanin; dopamine system; drug of abuse; drug relapse; drugs abused; drugs of abuse; feeding-related behaviors; fighting; hypothalamic; in situ Hybridization Staining Method; interest; melanin-concentrating hormone; melanin-concentrating hormone receptor; melanophore-concentrating hormone; melanosome concentrating hormone; molecuar profile; molecular signature; neuronal; novel; nutrient intake activity; preference; public health relevance; receptor; receptor expression; receptor, MCH; receptor, melanine-concentrating hormone; reinforced behavior; response; social role; teleost fish; teleostean fish; teleostfish; zona incerta",A novel neuropeptide system involved in drug abuse," PROJECT NARRATIVE If we can demonstrate that the MCH system can regulate the motivational aspect of drugs of abuse, we will have discovered a novel transmitter system involved in addiction. Since we may show that the MCH system may block drug relapse, our data may serve as a basis to use the MCH system as a possible target for helping fight drug of abuse.",24746,MNPS,Molecular Neuropharmacology and Signaling Study Section,A2,1,377974,
7781108,R01,DA,1,,02/01/2010,01/31/2011,PA-07-226,1R01DA025646-01A2,,NIDA:321834;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHAPEL HILL,UNITED STATES,PSYCHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"FUCHS LOKENSGARD, RITA A;",7732213;,1R01DA025646,02/01/2010,01/31/2015,"3'5'-cyclic ester of AMP; 3,4-Dihydroxyphenethylamine; 3,4-Pyrrolidinediol, 2-((4-methoxyphenyl)methyl)-, 3-acetate, (2R-(2alpha,3alpha,4beta))-; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Cocaine; Addiction, Drug; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Anisomycin; Behavior; Bilateral; Brain; Brain region; CNS plasticity; CaM KII; CaM PK II; CaM kinase II; CaMKII; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Chronic; Cocaine; Cocaine Dependences; Common Rat Strains; Complex; Cornu Ammonis; Cues; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dependence, Drug; Dependences, Cocaine; Development; Dopamine; Dorsal; Dose; Drug Addiction; Drug Dependency; Drug Therapy; Drugs; Elements; Encephalon; Encephalons; Extinction; Extinction (Psychology); Fear; Fiber; Figs; Figs - dietary; Freezing; Fright; Fugu Toxin; Future; Glutamates; Goals; Hippocampus; Hippocampus (Brain); Hydroxytyramine; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Intracellular Communication and Signaling; L-Glutamate; Mammals, Rats; Maps; Marshal; Measures; Mediating; Medication; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Method LOINC Axis 6; Methodology; Modeling; Nerve Impulse Transmission; Nerve Transmission; Nervous System, Brain; Neurobiology; Neurochemistry; Neuronal Plasticity; Neuronal Transmission; Nucleus Accumbens; PKA; Pathology; Pathway interactions; Peptide Biosynthesis, Ribosomal; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Play; Prevention; Prevention of relapse; Procedures; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase A; Protein Synthesis, Ribosomal; Proteins; Rat; Rattus; Recovery; Relapse; Relative; Relative (related person); Research; Retrieval; Role; Science of neurochemistry; Self Administration; Self-Administered; Short-Term Memory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Sum; TTX; Tarichatoxin; Testing; Tetradotoxin; Tetrodotoxin; Thinking; Thinking, function; Time; Training; Wolves; Work; addiction; adenosine 3'5' monophosphate; amygdaloid nuclear complex; base; behavioral extinction; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cocaine exposure; cocaine use; cue reactivity; disorder later incidence prevention; drug addiction pharmacotherapy; drug relapse; drug/agent; effective therapy; experiment; experimental research; experimental study; gene product; hippocampal; information processing; inhibitor; inhibitor/antagonist; interest; long term memory; model organism; neural plasticity; neuroadaptation; neurobiological; neurobiological mechanism; neurochemistry; neuroplasticity; neurotransmission; novel; pathway; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; protein expression; protein synthesis; public health relevance; puffer fish toxin; research study; response; social role; theories; working memory",Drug Context-Induced Instrumental Cocaine Seeking: Influence of Memory Reconsolid," PROJECT NARRATIVE This project will explore the functional neuroanatomical and cellular mechanisms of memory reconsolidation, which are postulated to stabilize cocaine-related associative memories and facilitate the ability of a drug- predictive context to trigger instrumental cocaine-seeking behavior in a rat model of drug relapse. The project is intended to provide rationale for (A) future research into pathological cocaine memory reconsolidation and (B) for the development of novel and more effective pharmacotherapies for cocaine addiction.",25646,NMB,Neurobiology of Motivated Behavior Study Section,A2,1,321834,
7791216,R01,DA,1,,01/15/2010,12/31/2010,PA-07-277,1R01DA025687-01A2,,NIDA:316159;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,,01,798390928,US,PA,191063414,"TREATMENT RESEARCH INSTITUTE, INC. (TRI)","DUGOSH, KAREN LEGGETT;",7905787;,1R01DA025687,01/15/2010,12/31/2012,"21+ years old; Admission; Admission activity; Adoption; Adult; Area; Client; Clinical; Coercion; Commit; Consent; Consultations; Controlled Study; Coupled; Crime; Criminal Justice; Development; Development and Research; Device or Instrument Development; Drug Courts; Ensure; Ethics; Ethics Committees, Research; Evaluation; Focus Groups; Human; Human, Adult; Human, General; IRBs; Imprisonment; Individual; Institutional Review Boards; Intervention; Intervention Strategies; Justice, Criminal; Lead; Man (Taxonomy); Man, Modern; Measures; Participant; Patients; Pb element; Perception; Phase; Population; Pressure; Pressure- physical agent; Prevalence; Prisons; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Psychometric; Psychometrics; Punishment; R & D; R&D; Randomized; Research; Research Ethics Committees; Scientist; Source; Staging; Structure; Substance Use Disorder; Substance abuse problem; Survey Instrument; Surveys; System; System, LOINC Axis 4; Testing; Vulnerable Populations; abuse of substances; adjudicate; adult human (21+); cognitive function; court; criminal offender; device development; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; human subject protection; improved; incarceration; instrument; instrument development; interventional strategy; meetings; offender; parolee; pressure; programs; psychopharmacologic; psychopharmacological; public health relevance; randomisation; randomization; randomly assigned; research and development; research study; response; substance abuse; substance abuser",Improving Ethics in Research Development of the Coercion Assessment Scale (CAS)," PROJECT NARRATIVE  Development of the Coercion Assessment Scale (CAS) responds to the need for an instrument to accurately measure perceptions of coercion among substance abusing criminal justice clients participating in research. Much like consent quizzes and tests of cognitive functioning, the CAS will be useful for identifying individuals who are not appropriate for research participation because of their level of perceived coercion. In this context, the CAS may be particularly useful to research staff, research intermediaries, and ethics review boards.",25687,ZRG1,Special Emphasis Panel,A2,1,316159,
7782871,R01,DA,1,,02/01/2010,01/31/2011,PA-07-070,1R01DA026431-01A1,,NIDA:317167;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BROOKLYN,UNITED STATES,BIOCHEMISTRY,11,040796328,US,NY,11203,SUNY DOWNSTATE MEDICAL CENTER,"CHAKRABARTI, SUMITA ;GINTZLER, ALAN R (contact);",1883856 (contact);9476131;,1R01DA026431,02/01/2010,01/31/2015,"21+ years old; Ablation; Acute; Adult; Agonist; Autoregulation; Binding; Binding (Molecular Function); Biochemical; Biological Preservation; Body Tissues; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Chronic; Co-Immunoprecipitations; Common Rat Strains; Complex; Contin, MS; Coupling; Data; Dependence; Dependency; Dependency (Psychology); Development; Dimensions; Dose; Drug Formulations; Drug Therapy; Effectiveness; Employee Strikes; Endo Brand of Naloxone Hydrochloride; Endogenous Opiates; Exhibits; Feedback; Female; Flexibility; Formulation; Formulations, Drug; G Protein-Coupled Receptor Signaling; G-Proteins; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Gonadal Steroid Hormones; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Homeostasis; Human, Adult; In Vitro; Infumorph; Intracellular Communication and Signaling; Kadian; Lamepro Brand of Naloxone Hydrochloride; MSir; Mammals, Rats; Masks; Medical; Medulla Spinalis; Modality; Modeling; Molecular Interaction; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; Naloxone; Narcan; Narcanti; Narcotics; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Oophorectomy; Opioid; Opioid Receptor; Oramorph; Oramorph SR; Ovarian; Ovariectomy; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTPA; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pharmacotherapy; Phenotype; Phosphorylation; Phosphotyrosyl Phosphatase Activator; Physiologic; Physiological; Physiological Homeostasis; Pliability; Preservation, Biologic; Preservation, Biological; Propanamide, N-(4-(methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenyl-; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Phosphorylation; Rat; Rattus; Receptor Activation; Receptor Inhibition; Receptor Signaling; Receptors, Opiate; Receptors, Opioid, mu; Receptors, mu; Recruitment Activity; Regulation; Relative; Relative (related person); Resolution; Roxanol; Sensory; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Spinal; Spinal Cord; Statex SR; Strikes; Strikes, Employee; Structure; Sufentanil; Sulfentanyl; System; System, LOINC Axis 4; Testing; Tissues; Tyr-Pro-Phe-Phe-NH2; United Drug Brand of Naloxone Hydrochloride; Withdrawal; Woman; addiction; adult human (21+); base; biological signal transduction; desensitization; emotional dependency; empowered; endogenous opioid; endomorphin 2; experience; female gonadectomy; gonadal steroids; in vivo; male; men; men's; neuronal; new approaches; novel; novel approaches; novel strategies; novel strategy; opioid withdrawal; pleiotropism; pleiotropy; preservation; public health relevance; receptor coupling; recruit; sex; sex dimorphism; sex steroid; sexual dimorphism; translational approach; tyrosyl-prolyl-phenylalanyl-phenylalaninamide",Sex-dependent tolerance and withdrawal mechanisms, This application will establish sexual dimorphic dimensions of opioid tolerance and withdrawal adaptations that influence the ability of the mu-opioid receptor (MOR) to regulate the release of endomorphin 2 (an endogenous opioid) from spinal cord. We will determine the effect of chronic systemic morphine and its acute in vitro with- drawal on the regulation by MOR of endomorphin 2 released from spinal cord of male and female rats. Eluci- dation of sex-dependent aspects of addictive states should profoundly influence their medical management and help to maximize the effectiveness of pain control strategies that are utilized in women as well as men.,26431,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",A1,1,317167,
7782392,R01,DA,1,,01/15/2010,12/31/2010,PA-08-263,1R01DA026469-01A1,,NIDA:394144;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,,01,798390928,US,PA,191063414,"TREATMENT RESEARCH INSTITUTE, INC. (TRI)","BROOKS, ADAM C;",8215018;,1R01DA026469,01/15/2010,12/31/2012,"Address; Adherence; Adherence (attribute); Adoption; Affect; Algorithms; Area; Attention; Award; Behavior Therapy, Cognitive; Behavioral; Behavioral Therapy; Benchmarking; Best Practice Analysis; Caring; Clinical; Clinical Data; Cognitive; Cognitive Therapy; Collaborations; Communities; Coping Skills; Counselor; Data; Data Collection; Delaware; Development; Documentation; Drops; Drugs; Early treatment; Electronics; Elements; Evaluation; Evidence based intervention; Evidence based practice; Feasibility Studies; Feedback; Funding; Government; Graph; Instruction; Intake; Intervention; Intervention Strategies; Intervention Studies; Learning; Left; Length of Stay; MT-bound tau; Measures; Medical; Medication; Modeling; Monitor; Monitoring, Patient; Number of Days in Hospital; On-Line Systems; Online Systems; Out-patients; Outcome; Outpatients; PROV; Paper; Patient Monitoring; Patient Self-Report; Patients; Pattern; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Procedures; Process; Professional counselor; Programs (PT); Programs [Publication Type]; Progress Reports; Provider; Psychotherapy, Cognitive; Randomized; Randomized Clinical Trials; Records; Recovery; Reporting; Reports, Progress; Research; Self-Report; Services; Skills, Coping; Staging; Substance abuse problem; Supervision; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Therapy, Cognition; Time; Training; Translating; Translatings; Treatment outcome; Trials, Randomized Clinical; Urinary System, Urine; Urine; abuse of substances; addiction; base; brief intervention; clinical efficacy; clinical practice; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; dissemination research; drug/agent; efficacy testing; evidence base; flexibility; high risk; hospital days; hospital length of stay; hospital stay; improved; instrument; intervention development; intervention therapy; interventional strategy; language translation; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; online computer; programs; psychosocial; public health relevance; randomisation; randomization; randomly assigned; response; substance abuse; tau; tau Proteins; tau factor; therapy development; treatment development; treatment program; treatment site; trial comparing; web based",Evaluation of Web-based Recovery Monitoring with Clinical Alerts," PROJECT NARRATIVE The proposed project will modify an existing state-wide Web-based monitoring system to alert counselors with feedback regarding patients at highest risk for treatment drop out. RecoveryTrack + Clinical Alerts is a monitoring and intervention system that clinical staff can easily incorporate into their usual practice with minimal training and has the potential to be portable, practical and sustainable as recommended for the field. It will allow both counselors and supervisors to monitor patient clinical status and progress and to intervene with patients at high risk for treatment attrition.",26469,NIDA,Neuropharmacology Research Subcommittee,A1,1,394144,
7782424,R01,DA,1,,12/01/2009,11/30/2010,PA-07-226,1R01DA026487-01A1,,NIDA:328680;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"DEADWYLER, SAMUEL A.;",1887844;,1R01DA026487,12/01/2009,11/30/2014,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abuse, Cocaine; Acute; Addiction, Cocaine; Affect; Animals; Area; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Cephalon brand of modafinil; Cerebrum; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Abuse; Cocaine Dependences; Cognition; Cognitive; D-Glucose; Dependence; Dependences, Cocaine; Dextrose; Dorsal; Drug Compounding; Drug Preparation; Drug effect disorder; Drugs; Effectiveness; Encephalon; Encephalons; Exposure to; Glucose; History; Human; Human, General; Image; Individual; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigation; Juice; Laboratories; Lead; Man (Taxonomy); Man, Modern; Measures; Medial; Medical Imaging, Positron Emission Tomography; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Metabolic; Modafinil; Modeling; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; PET; PET Scan; PET imaging; PETSCAN; PETT; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic; Physiological; Positron Emission Tomography Scan; Positron-Emission Tomography; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Provigil; Psyche structure; Psychological reinforcement; Public Health; R01 Mechanism; R01 Program; RPG; Rad.-PET; Recording of previous events; Regimen; Reinforcement; Reinforcement (Psychology); Relative; Relative (related person); Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rewards; Sampling; Self Administration; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Sleep Deprivation; Societies; Stress; Striatum, Ventral; Structure; Temporal Lobe; Testing; Therapeutic; Time; Ventral Striatum; base; benzhydrylsulfinylacetamide; biological signal transduction; clinical investigation; cocaine exposure; cognitive function; craving; drug action; drug candidate; drug/agent; executive control; executive function; experience; hcrt receptor 1; hctr1; heavy metal Pb; heavy metal lead; hypocretin-1 receptor; imaging; information processing; mental; neuroimaging; neuronal; non-human primate; nonhuman primate; orexin A receptor; preference; programs; public health medicine (field); public health relevance; temporal cortex; temporal lobe/cortex; working memory",Neuroimaging Correlates of Cocaine Reinforcement for Cognitive Performance, The relevance of this Project to public health is directly related to finding agents and drugs that will alleviate the dependence on substances that are abused in society. Primarily the Program will focus on the effects of cocaine on cognition in nonhuman primates which serves as the final testbed for candidate drugs that can lead to therapeutic treatment of cocaine abusers.,26487,NMB,Neurobiology of Motivated Behavior Study Section,A1,1,328680,
7762683,R01,DA,1,,01/15/2010,12/31/2010,DA-09-013,1R01DA027535-01,,NIDA:393167;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ATLANTA,UNITED STATES,GENETICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HOLMES, PHILIP V;WEINSHENKER, DAVID  (contact);",1877517 (contact);1885456;,1R01DA027535,01/15/2010,12/31/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Addiction, Cocaine; Addiction, Drug; Adrenergic Agents; Adrenergic Drugs; Adrenergics; Aerobic Activity; Aerobic Exercise; Affect; Animal Model; Animal Models and Related Studies; Attenuated; Autoreceptors; Brain; Brain region; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Chemical Dependence; Chronic; Circulatory Collapse; Cocaine; Cocaine Dependences; Common Rat Strains; Cues; Dependence, Drug; Dependences, Cocaine; Drip Infusions; Drip, Intravenous; Drug Addiction; Drug Dependency; Drug Exposure; Drug Therapy; Drug abuse; Drugs; Economics; Encephalon; Encephalons; Exercise; Exercise, Physical; Exposure to; Extinction; Extinction (Psychology); Feeling; Foot; Fore-Brain; Forebrain; Galanin; Galanin (1-29); Gene Expression; Genetics, in situ Hybridization; Human; Human, General; IV Infusion; In Situ Hybridization; Individual; Infusion; Infusion procedures; Infusions, Intravenous; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Intravenous infusion procedures; Investigation; Levarterenol; Levonorepinephrine; Link; Locus Coeruleus; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medical; Medication; Mental Health; Mental Hygiene; Messenger RNA; Microdialysis; Modeling; Monkeys; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptides; Noradrenaline; Norepinephrine; Nucleus; Nucleus Pigmentosus Pontis; Pathway interactions; Pes; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Physical activity; Prevention; Process; Prosencephalon; Psyche structure; Psychological Health; RNA, Messenger; RT-PCR; RTPCR; Rat; Rattus; Recurrent disease; Regimen; Relapse; Relapsed Disease; Research; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Rewards; Rodent Model; Role; Running; Self Administration; Shock; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Stimulus; Stress; Structure of locus ceruleus; System; System, LOINC Axis 4; Testing; Time; Training; Transmission; Treatment outcome; Up-Regulation; Up-Regulation (Physiology); Upregulation; abuse of drugs; abuses drugs; acute stress; adrenergic; animal data; behavioral extinction; biological signal transduction; blue nucleus; circulatory shock; drug relapse; drug seeking behavior; drug/agent; effective therapy; experiment; experimental research; experimental study; feelings; foot; galanin receptor; human relapse; improved; in situ Hybridization Staining Method; in vivo; inhibitor; inhibitor/antagonist; insight; locus ceruleus structure; mRNA; mental; model organism; neural mechanism; neuromechanism; neuronal; noradrenergic; novel; pathway; physical conditioning; prevent; preventing; psychologic; psychological; public health relevance; research study; resistant; response; reverse transcriptase PCR; reward circuitry; sedentary; social; social role; substance abuse prevention; transmission process",Effects of voluntary exercise on reinstatement of cocaine seeking," Project Narrative Drug addiction is a chronic, relapsing disease that is very difficult to treat and places enormous social and economic stress on society. Aerobic exercise is beneficial for many aspects of physical and mental health, and may be beneficial for the treatment of drug dependence. The purpose of this proposal is to assess the effects of aerobic exercise in a rat model of drug relapse, and to investigate potential underlying mechanisms. Completion of these experiments may indicate a new therapy for the treatment of drug addiction.",27535,ZDA1,Special Emphasis Panel,,1,393167,
7770131,R01,DA,1,,01/15/2010,12/31/2010,PA-07-070,1R01DA027761-01,,NIDA:353921;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,08,080481880,US,NY,100103509,NATIONAL DEVELOPMENT & RES INSTITUTES,"DUNLAP, ELOISE  (contact);ELLIOTT, LUTHER ;REAM, GEOFFREY LEWIS;",10361901 (contact);9369745;9785311;,1R01DA027761,01/15/2010,12/31/2012,"12-20 years old; 17 year old; 21+ years old; AOD use; Address; Adolescence; Adult; Affective; Alcohol or Other Drugs use; American; Arousal; Behavior; Brain; Characteristics; Childhood; Cognitive; Commit; Complex; Data; Data Collection; Demographic Factors; Dependence; Development; Drugs; Encephalon; Encephalons; Engineering; Engineerings; Environment; Esthesia; Ethnography; Exhibits; Female; Functional Magnetic Resonance Imaging; Generalized Growth; Grips; Growth; Health; Human, Adult; Interview; Label; Latino; Lead; Life Cycle; Life Cycle Stages; MRI, Functional; Magnetic Resonance Imaging, Functional; Medication; Metabolic; Methods; Modeling; Neighborhoods; Nervous System, Brain; New York City; Operation; Operative Procedures; Operative Surgical Procedures; Parents; Pattern; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Policies; Population; Problem behavior; Relaxation; Research; Rewards; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Ritual compulsion; Rituals; Role; Sampling; Sensation; Socioeconomic Factors; Staging; Stealing; Stealings; Stress; Substance abuse problem; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Teen; Teenagers; Teens; Testing; Theft; Time; Tissue Growth; Trademark; Video Games; Violence; Work; abuse of substances; addiction; adolescence (12-20); adult human (21+); at risk behavior; base; behavioral problem; biobehavior; biobehavioral; career; coping; deviancy; deviant; drug/agent; emerging adult; ethnographic; experience; fMRI; grasp; heavy metal Pb; heavy metal lead; high risk; informant; life course; male; meetings; member; ontogeny; pediatric; preconditioning; prevent; preventing; psychologic; psychological; psychosocial; public health relevance; research in practice; response; seventeen year old; sex; skills; social; social role; socioeconomic; socioeconomically; socioeconomics; substance abuse; substance use; surgery; teen years; teenage; theories; video game violence; violent; violent behavior",Video Games' Role in Developing Substance Use," Public Health Relevance Statement Video gaming is often labeled as ""addictive"" and is alleged to contribute to substance use. This project will provide unavailable information about whether and how different genres of video gaming may contribute to substance use/dependence. It will also clearly distinguish the highest-risk subpopulations and locate the most effective points in the life course at which parents and/or public control policies could to intervene to prevent problematic involvements. It could also provide a basis for developing treatments for video gaming addiction and/or possible inclusion in substance abuse treatments.",27761,CIHB,Community Influences on Health Behavior,,1,353921,
7769634,R01,DA,1,,01/15/2010,12/31/2010,PA-07-070,1R01DA027845-01,,NIDA:317573;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,GRAND FORKS,UNITED STATES,PHARMACOLOGY,00,102280781,US,ND,58202,UNIVERSITY OF NORTH DAKOTA,"HENRY, LOREN KEITH (contact);VAUGHAN, ROXANNE A;",2283809;6772619 (contact);,1R01DA027845,01/15/2010,12/31/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 5HT transporter; 5HTT protein; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Active Sites; Assay; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Chemicals; Clinical; Cluster Analyses; Cluster Analysis; Cocaine; Combining Site; Computer Simulation; Computerized Models; Computing Methodologies; Cysteine; DAT; DAT dopamine transporter; Data; Digestion; Docking; Drug Compounding; Drug Preparation; Drugs; Family member; Generations; Genetics-Mutagenesis; Half-Cystine; Homology Modeling; Integral Membrane Protein; Intrinsic Membrane Protein; Investigation; L-Cysteine; L-Methionine; Lead; Levarterenol; Levonorepinephrine; Libraries; Ligand Binding; Ligands; Link; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Mental Health; Mental Hygiene; Methionine; Methionine, L-Isomer; Methods; Modeling; Models, Computer; Models, Molecular; Models, Structural; Molecular; Molecular Biology, Mutagenesis; Molecular Dynamics Simulation; Molecular Interaction; Molecular Models; Mutagenesis; Mutagenesis, Site-Directed; Neurologic; Neurological; Noradrenaline; Norepinephrine; Nucleic Acid Biochemistry, Molecular Modeling; Outcome; Pb element; Peptide Fingerprinting; Peptide Mapping; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Psychological Health; Reactive Site; Role; Scanning; Sequence Alignment; Simulation, Computer based; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Structural Models; Structure; Targeted DNA Modification; Targeted Modification; Testing; Transmembrane Protein; Tropanes; abused drugs; addiction; analog; base; clinical relevance; clinically relevant; comparative; computational methodology; computational methods; computational modeling; computational models; computational simulation; computational studies; computer based models; computer methods; computer studies; computerized modeling; computerized simulation; cross-link; crosslink; dopamine transporter; dopamine transporter proteins; drug of abuse; drug seeking behavior; drug/agent; drugs abused; drugs of abuse; flexibility; gene product; heavy metal Pb; heavy metal lead; in silico; inhibitor; inhibitor/antagonist; molecular dynamics; molecular modeling; novel; programs; protein folding; public health relevance; serotonin transporter; social role; sodium-dependent serotonin transporter; transporter (molecular); uptake; virtual simulation",Computational and Biochemical Docking of Dopamine Transporter Antagonists," Narrative The dopamine transporter is a major target of several drugs of abuse and has been linked to addiction and drug seeking behaviors, and as such is a highly clinically relevant protein. However, we still do not understand many of the details regarding the basis of drug recognition at DAT, or how various DAT drugs induce particular behavioral outcomes. Understanding the molecular basis of these properties could lead to important advances in clinical targeting of DAT as well as the related norepinepherine and serotonin transporters, all which play critical roles in our neurological and psychological health.",27845,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,1,317573,
7782943,R01,DC,1,,02/01/2010,01/31/2011,PA-07-070,1R01DC009980-01A1,,NIDCD:383670;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BALTIMORE,UNITED STATES,PHYSICAL MEDICINE & REHAB,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GERMAN, REBECCA Z;",1888589;,1R01DC009980,02/01/2010,01/31/2015,"Address; Affect; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Behavior; Bilateral; Biomechanics; Bolus; Bolus Infusion; Buccal Cavity; Cavitas Oris; Cell Communication and Signaling; Cell Signaling; Clinical; Compensation; Complex; Contralateral; Crossing Over; Crossing Over, Genetic; DYSPH; Data; Deglutition; Deglutition Disorders; Denervation; Disease; Disorder; Dysfunction; Dysphagia; EMG; Electromyography; Esophageal Sphincter, Upper; Ethics; Event; Extravasation; FLR; Failure (biologic function); Family suidae; Financial compensation; Functional disorder; Genetic Crossing Over; Head and Neck, Buccal Cavity; Head and Neck, Larynx; Head and Neck, Pharynx; Health; Human; Human Activities; Human, General; Infant; Injury; Intracellular Communication and Signaling; Ipsilateral; Laryngeal; Laryngeal Nerves; Larynx; Leakage; Length of Life; Lesion; Locomotor Activity; Longevity; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanics; Medical; Methods; Modeling; Motor; Motor Activity; Mouth; Movement; Muscle; Muscle Tissue; Muscle function; Nerve; Nervous; Neural Pathways; Operation; Operative Procedures; Operative Surgical Procedures; Oral cavity; Oropharyngeal; Oropharynx; Oropharynxs; Palate, Soft; Pattern; Penetration; Peripheral; Personal Satisfaction; Pharyngeal structure; Pharynx; Pharynxs; Physical Health Services / Rehabilitation; Physiopathology; Pigs; Recovery; Recurrent Laryngeal Nerve; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Rest; Science of Anatomy; Sensory; Side; Signal Transduction; Signal Transduction Systems; Signaling; Soft Palate; Spillage; Stimulus; Structure; Structure of superior laryngeal nerve; Suidae; Superior Laryngeal Nerve; Surgical; Surgical Interventions; Surgical Procedure; Swallowing; Swallowing Disorders; Swine; System; System, LOINC Axis 4; Throat; Trauma; UES; Upper Esophageal Sphincter; Velum Palatinum; anatomy; base; biological signal transduction; body movement; design; designing; disease/disorder; experiment; experimental research; experimental study; failure; kinematics; life span; lifespan; model organism; motor control; motor deficit; nerve injury; neural control; neural injury; neural regulation; neuroregulation; nonsister chromatid exchange; oral pharyngeal; pathophysiology; porcine; public health relevance; rehabilitative; research study; response; suid; surgery; voice box; well-being",Dysphagia and Recovery After Vagal or Laryngeal Nerve Injury," Due to its extensive anatomic course and vulnerability to disease and trauma, injury to the vagus and its laryngeal branches is not an uncommon medical finding across the lifespan. Determination of the functional consequences of such injuries will elucidate how disruption of the biomechanical integrity of the oropharyngeal system produces dysphagia. Establishing the pathophysiologic basis for dysphagia is the first step towards developing an effective rehabilitative strategy for this condition.",9980,MFSR,"Motor Function, Speech and Rehabilitation Study Section",A1,1,383670,
7793296,R01,DC,1,,02/01/2010,01/31/2011,PA-07-085,1R01DC010191-01A1,,NIDCD:529368;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHAPEL HILL,UNITED STATES,OTHER HEALTH PROFESSIONS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"LOSH, MOLLY C;",6140865;,1R01DC010191,02/01/2010,01/31/2015,"0-11 years old; Active Follow-up; Address; Affect; Approaches to prevention; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Causality; Characteristics; Child; Child Youth; Childhood; Children (0-21); Clinical; Cognitive; Collection; Complement; Complement Proteins; Complex; DISSEC; DNA; Data; Deoxyribonucleic Acid; Development; Diagnostic; Dissection; Etiology; Family; Family Study; Future; Genes; Genetic; Genetic Markers; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genotype; Heritability; Human, Child; Impairment; Individual; Inherited Predisposition; Inherited Susceptibility; Intervention; Intervention Strategies; Kanner's Syndrome; Language; Language Development; Language Disorders; Language disability; Lead; Life; Linguistic; Linguistics; Measures; Methods; Molecular Genetic; Molecular Genetics; Neurocognitive; Neurodevelopmental Disorder; Neurological Development Disorder; Parents; Pathogenesis; Pattern; Pb element; Personality; Phenotype; Prevention approach; Process; Production; Psycholinguistic; Psycholinguistics; Records; Relative; Relative (related person); Research; Research Design; Research Resources; Resources; Sampling; Social Functioning; Societies; Speech; Study Type; Symptoms; Syndrome; Twin Multiple Birth; Twins; Work; acquiring language skills; base; biobank; children; cohort; developmental disease/disorder; developmental disorder; disease causation; disease etiology; disease/disorder etiology; disorder etiology; evidence base; experiment; experimental research; experimental study; family genetics; follow-up; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome-wide; heavy metal Pb; heavy metal lead; indexing; insight; interest; interventional strategy; language acquisition; language deficit; language learning; language processing; neuropsychological; pediatric; public health relevance; research study; skills; social; study design; trait; youngster",A Family-Genetic Study of Language in Autism, This project aims to identify specific linguistic markers of genetic liability to autism which may be used to illuminate the pathogenesis of autism and its component features. Research aimed at uncovering the pathogenesis of autism may lead to evidence-based approaches to prevention or treatment. ,10191,CPDD,Child Psychopathology and Developmental Disabilities Study Section,A1,1,529368,
7762673,R01,DC,1,,02/01/2010,01/31/2011,PA-07-095,1R01DC010367-01,,NIDCD:347110;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","JOSEPHS, KEITH A;",9040102;,1R01DC010367,02/01/2010,01/31/2015,"6-hydroxybenzothiazole; Activities of Daily Living; Activities of everyday life; Algorithms; Alzheimer; Alzheimer beta-Protein; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimer's amyloid; Alzheimers Dementia; Alzheimers disease; Amentia; Amyloid Alzeheimer's Dementia Amyloid Protein; Amyloid Beta-Peptide; Amyloid Fibril Protein (Alzheimer's); Amyloid Protein A4; Amyloid beta-Protein; Amyloid beta-Protein, Alzheimer's; Amyloid deposition; Anomia; Anomic Dysphasia; Aphasia, Amnesic; Aphasia, Anomic; Aphasia, Nominal; Area; Articulation; Atomic Medicine; Atrophic; Atrophy; Au element; Autopsy; Behavioral; Brain; Center for Translational Science Activities; Clinic; Clinical; Comprehension; D-Glucose; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deposit; Deposition; Detection; Development; Dextrose; Diagnosis; Discipline of Nuclear Medicine; Disease; Disorder; Doctor of Philosophy; Dysfunction; Dyskinesia Syndromes; Dysnomia; Dysnomias; Dysphasias, Anomic; Encephalon; Encephalons; Equipment; Extremities; Foundations; Frontotemporal Lobar Degenerations; Functional disorder; Future; Glucose; Goals; Gold; Grant; Hand; Image; Imaging Procedures; Imaging Techniques; Impairment; Investigators; Joints; Laboratories; Language; Language Disorders; Language disability; Lead; Limb structure; Limbs; Lobar Degenerations, Frontotemporal; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Manuscripts; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Medical center; Memory; Memory Loss; Methods; Methods and Techniques; Methods, Other; Minority; Movement Disorder Syndromes; Movement Disorders; NMR Imaging; NMR Tomography; Nervous System Diseases; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological; Neurological Disorders; Neurology; Neuropsychologic Tests; Neuropsychological Tests; Neurosciences; Nominal Dysphasia; Nominal Dysphasias; Non-Trunk; Nuclear; Nuclear Magnetic Resonance Imaging; Nuclear Medicine; PET; PET Scan; PET imaging; PETSCAN; PETT; Parietal Lobe; Parietal Lobe of the Brain; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Pathology; Patients; Pb element; Peer Review; Ph.D.; PhD; Physiopathology; Pittsburgh Compound-B; Position; Positioning Attribute; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Senile Degenerative Dementia; Principal Investigator; Prize; Production; Progressive Aphasias; Proteins; Proton Magnetic Resonance Spectroscopic Imaging; Publications; Publishing; RDST; Rad.-PET; Radiology; Radiology / Radiation Biology / Nuclear Medicine; Radiology Specialty; Radiology, General; Radiology-Nuclear Medicine; Recruitment Activity; Research; Research Personnel; Researchers; Rest; Scanning; Scientific Publication; Scientist; Severities; Solid; Solutions; Specialist; Speech; Speech Pathologist; Speech Pathology; Technics, Imaging; Techniques; Testing; Training; United States; Visuospatial; Work; Zeugmatography; a beta peptide; abeta; amyloid beta; amyloid imaging; amyloid-b protein; aphasic; base; beta amyloid associated pathology; beta amyloid fibril; beta amyloid pathology; biomarker; cost effective; daily living functionality; dementia of the Alzheimer type; diagnosis evaluation; disease/disorder; executive control; executive function; expectation; experience; frontal cortex; frontal lobe; functional ability; functional capacity; gene product; gray matter; heavy metal Pb; heavy metal lead; imaging; in vivo; innovate; innovation; innovative; language deficit; ligand PIB; necropsy; nervous system disorder; neurodegenerative illness; neurological disease; neuropsychological; parietal cortex; pathophysiology; postmortem; primary degenerative dementia; public health relevance; radiologist; recruit; senile dementia of the Alzheimer type; soluble amyloid precursor protein; substantia grisea; tomography; visual spatial",PIB PET Scanning in Speech and Language Based Dementias," PROJECT NARRATIVE This study will identify ways to determine whether Alzheimer's disease is the underlying cause of a patient's progressive speech and language problem. In addition, the study aims to identify the most cost effective way to do this so that more patients, including minorities, can be given an accurate diagnosis. Results from this grant will ultimately lead to better targeted future treatments for patients with problems with speech and language.",10367,LCOM,Language and Communication Study Section,,1,347110,
7781220,R01,EB,1,,02/01/2010,01/31/2011,PA-07-070,1R01EB008699-01A2,,NIBIB:347625;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,SAN FRANCISCO,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ZHANG, XIAOLIANG ;",7941567;,1R01EB008699,02/01/2010,01/31/2014,"Abnormal Assessment of Metabolism; Apoplexy; Applications Grants; Basic Research; Basic Science; Bioenergetic; Bioenergetics; California; Cardiac; Cardiac infarction; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Communities; Detection; Development; Diagnosis, clinical; Disease; Disorder; Drugs; Elements; Engineering; Engineerings; Evaluation; Frequencies (time pattern); Frequency; Funding; Future; Goals; Grant Proposals; Grants, Applications; H+ element; Head; Health; Human; Human, General; Hydrogen Ions; Image; Imaging Procedures; Imaging Techniques; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Label; METBL; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Magnetism; Man (Taxonomy); Man, Modern; Maps; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Metabolic; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Myocardial Infarct; Myocardial Infarction; NMR Imaging; NMR Tomography; Noise; Nuclear; Nuclear Magnetic Resonance Imaging; Nucleus; O element; O2 element; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Oxygen; Pathology; Patients; Penetration; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiology; Play; Protons; Public Health; Pyruvate; Pyruvates; RF coil; Radiation; Research; Role; Safety; San Francisco; Science; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Solutions; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Speed; Speed (motion); Spinal Column; Spine; Stroke; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Technology; Time; Transmission; Universities; Validation; Vascular Accident, Brain; Vertebral column; Zeugmatography; backbone; base; biological signal transduction; brain attack; cardiac infarct; cerebral vascular accident; clinical Diagnosis; coronary attack; coronary infarct; coronary infarction; design; design and construction; designing; disease/disorder; drug/agent; experience; flexibility; heart attack; heart infarct; heart infarction; human subject; imaging; imaging modality; improved; in vivo; magnetic; metabolic abnormality assessment; pre-clinical; preclinical; public health medicine (field); public health relevance; ray (radiation); social role; spectroscopic imaging; stroke; success; surgery; theories; transmission process",Multichannel Dual-tuned Transceiver Techniques for Human Low-Gamma Nuclei MR," Relevance to Public Health: The successful outcome of the proposed project will advance the low-gamma nuclear MRI/MRSI with high sensitivity and speed for studying metabolism and physiology in health and diseased conditions in human non- invasively, and make the low-gamma nuclear, in particular, hyperpolarized 13C, MRI/MRSI clinically practical. The research effort will have an immediately impact to better understanding of human physiology, pathology, metabolism and diseases, at molecular level possibly.",8699,BMIT,Biomedical Imaging Technology Study Section,A2,1,347625,
7767586,R01,EB,1,,02/01/2010,01/31/2011,PA-07-279,1R01EB010043-01,,NIBIB:350172;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CINCINNATI,UNITED STATES,ENGINEERING (ALL TYPES),01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"HO, CHIA-CHI ;",7671710;,1R01EB010043,02/01/2010,01/31/2014,"Actins; Address; Adhesions; Adhesives; Area; Automobiles; Biocompatible Materials; Biological; Biomaterials; Biomaterials Research; Body Tissues; Cell Body; Cell Communication and Signaling; Cell Count; Cell Function; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Migration Pathway; Cell Movement; Cell Number; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Shape; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Chemicals; Chemoattractants; Chemotactic Factors; Chemotaxins; Collaborations; Complex; Cues; Cytoskeletal System; Cytoskeleton; Family; Foundations; Funding; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HGF/SF; Hepatic Cells; Hepatic Parenchymal Cell; Hepatic Stellate Cell; Hepatocyte; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; In Vitro; Intracellular Communication and Signaling; Island; Ito Cell; Lead; Liver; Liver Cells; Location; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; Mammalian Cell; Mechanics; Methods and Techniques; Methods, Other; Molecular; Molecular Genetic; Molecular Genetics; Motility; Motility, Cellular; Movement; Natural regeneration; Nerve Cells; Nerve Regeneration; Nerve Unit; Neural Cell; Neurocyte; Neurons; Organ; PTK Receptors; Pattern; Pattern Formation; Pb element; Position; Positioning Attribute; Process; Public Health; RTK; Receptor Protein-Tyrosine Kinases; Regeneration; Regulation; Research; Resolution; Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration; Scatter Factor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; TLC; Techniques; Technology; Thin Layer Chromatography; Time; Tissue Engineering; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Vascularization; analog; base; biological research; biological signal transduction; biological systems; body movement; body system, hepatic; cell assembly; cell body (neuron); cell growth; cell motility; cell sorting; cell type; complement chemotactic factor; cost; cultured cell line; design; designing; directional cell; disease diagnosis; engineered tissue; heavy metal Pb; heavy metal lead; in vivo; intracellular skeleton; migration; multidisciplinary; nervous system regeneration; neural cell body; neural regeneration; neuronal; neuronal cell body; next generation; organ system, hepatic; polymerization; public health medicine (field); public health relevance; regenerate; response; rho; scaffold; scaffolding; self assembly; shear stress; soma; trafficking",One Way Micropatterns for Self-Assembly and Sorting of Cells, The application is relevant to public health as a low-cost cell sorting technology for rapid screening/purification of cells or diagnosis of diseases related to cell motility and can be applied to engineer tissues by 3D scaffolds that direct migration of multiple cell types.,10043,BMBI,Biomaterials and Biointerfaces Study Section,,1,350172,
7792699,R01,EB,1,,02/01/2010,01/31/2011,PA-07-070,1R01EB011785-01A2,,NIBIB:624923;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,BLACKSBURG,UNITED STATES,ENGINEERING (ALL TYPES),09,003137015,US,VA,24060,VIRGINIA POLYTECHNIC INST AND ST UNIV,"DE MAN, BRUNO ;WANG, GE  (contact);",1874878 (contact);9341763;,1R01EB011785,02/01/2010,01/31/2013,"Affect; Algorithms; American; Anatomic; Anatomical Sciences; Anatomy; Architecture; Artifacts; Arts; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cardiac; Cardiovascular Diseases; Clinical; Clinics and Hospitals; Clinics or Hospitals; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Cone; Cones (Eye); Cones (Retina); Data; Development; Diagnostic; Dose; EMI scan; Electron Beam Computed Tomography; Electron Beam Tomography; Elements; Engineering; Engineering / Architecture; Engineerings; Ensure; Evaluation; Functional Imaging; Generations; Goals; Health Care Costs; Health Costs; Healthcare Costs; Heart; Image; Investigators; Knowledge; Low Dose Radiation; Measurement; Measures; Morbidity; Morbidity - disease rate; Morphologic artifacts; Mortality; Mortality Vital Statistics; Motion; Noise; Outcome; Patients; Performance; Phase; Photoreceptors, Cone; Physiologic Imaging; Protocol; Protocols documentation; Publishing; Radiation; Radon; Research; Research Personnel; Researchers; Resolution; Retinal Cone; Rn element; Rotation; Sampling; Scanning; Scheme; Science of Anatomy; Source; Speed; Speed (motion); Spottings; Staging; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Technology; Testing; Theoretical Studies; Therapeutic; Tomodensitometry; Tomography, Computed, Scanners; Tomography, Xray Computed; Virginia; Weight; X-Ray Computed Tomography; anatomy; base; cardiac motion; cardiovascular disorder; catscan; computed axial tomography; computerized axial tomography; computerized tomography; cone cell; design; designing; detector; experiment; experimental research; experimental study; heart motion; imaging; improved; indexing; innovate; innovation; innovative; next generation; novel; prototype; public health relevance; quantum; ray (radiation); reconstruction; research study; simulation; social",Cardiac CT: Advanced Architectures and Algorithms, Project Narrative Cardiovascular diseases are pervasive with high mortality and morbidity at tremendous social and healthcare costs. Cardiac CT technology needs major improvements to capture a fast beating heart with better image clarity at lower radiation dose. The overall goal of this project is to develop the next generation cardiac CT architecture and algorithms for significantly superior diagnostic performance and therapeutic outcomes that affect 61.8 million Americans.,11785,ZRG1,Special Emphasis Panel,A2,1,624923,
7731583,R01,ES,1,,01/13/2010,11/30/2010,PA-07-070,1R01ES016769-01A1,,NIEHS:655726;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ANN ARBOR,UNITED STATES,PEDIATRICS,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LEWIS, TOBY C;",7856212;,1R01ES016769,01/13/2010,11/30/2014,"0-11 years old; 15-F(2t)-IsoP; 15-F(2t)-isoprostane; 8-F(2t)-isoprostane; 8-iso-PGF(2alpha); 8-iso-PGF2alpha; 8-isoprostaglandin F2alpha; 8-isoprostane; Acute; Adhesions; Affect; Air; Air Pollutants; Air Pollution; Airway Hyper-responsiveness; Animals; Anionic Neutrophil-Activating Peptide; Arts; Asthma; Asthma in Children; Automobile Exhaust; Biological; Bronchial Asthma; Budgets; Build-it; CD54 (ICAM 1); CD54 Antigens; Characteristics; Chemotactic Factor, Macrophage-Derived; Chemotactic Factor, Neutrophil; Chemotactic Factor, Neutrophil, Monocyte-Derived; Child; Child Youth; Child health care; Childhood Asthma; Children (0-21); Clinical; Clinical Pathways; Cohort Studies; Common Rat Strains; Complex; Concurrent Studies; Diesel Exhaust; Disease; Disorder; Distant; Douching, other than vaginal; Drugs; Dysfunction; ELISA; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enrollment; Enzyme-Linked Immunosorbent Assay; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epithelial Cells; Equation; Evaluation; Exhalation; Exhaling; Exhaust, Automobile; Exhaust, Diesel; Expiration, Respiratory; Exposure to; FEV1; FEV1%VC; Figs; Figs - dietary; Forced Expiratory Volume 1 Test; Forced Expiratory Volume in 1 Second; Foundations; Free Radicals; Frequencies (time pattern); Frequency; Functional disorder; Funding; GCP-IL-8; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Granulocyte Chemotactic Peptide-Interleukin-8; Health; Health Diary; Health Status; Health, Child; Home; Home environment; Human, Child; ICAM-1; IFN; INFLM; Incidence; Inflammation; Inflammatory; Infrastructure; Intercellular Adhesion Molecules; Intercellular adhesion molecule 1; Interferons; Interleukin-8; Investigators; Irrigation; Irrigation, other than vaginal; Knowledge; LDL; Laboratories; Lavage; Leukocyte Adhesion Inhibitor; Level of Health; Life; Linear Models; Lipoprotein LDL Receptors; Lipoproteins, LDL; Liquid substance; Low Density Lipoprotein Receptor; Low-Density Lipoproteins; Lower respiratory tract structure; Lung; Mammals, Rats; Measures; Medical; Medication; Messenger RNA; Michigan; Modeling; Molecules, Intercellular Adhesion; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Nasal; Nature; Neutrophil Activating Peptide; Neutrophil Activation Factor; Neutrophil Activation Peptide; Neutrophil-Activating Peptide, Lymphocyte-Derived; Neutrophil-Activating Peptide, Monocyte-Derived; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Dioxide; Nitrogen Monoxide; Nitrogen Peroxide; Nitrogen Protoxide; Nitrogen oxide; Nitrogen oxide (NO2); Nonvaginal irrigation; Nonvaginal lavage; Nose; Nose, Nasal Passages; Outcome; Outcome Measure; Oxidative Stress; PFT/FEV1; Participant; Pathway interactions; Pathways, Clinical; Patient Self-Report; Pediatric asthma; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiopathology; Policies; Pollution; Predisposition; Prospective Studies; Proteins; Public Health; Pulmonary Body System; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary Organ System; R01 Mechanism; R01 Program; RNA, Messenger; RPG; RT-PCR; RTPCR; Rat; Rattus; Receptor Protein; Receptors, LDL; Receptors, Virus; Recruitment Activity; Reporting; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Specimen; Researchers; Resources; Respiratory Infections; Respiratory System; Respiratory System, Lung; Respiratory System, Nose, Nasal Passages; Respiratory Tract Infections; Respiratory physiology; Respiratory system (all sites); Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Robin; Robin bird; Role; Schools; Screening procedure; Self-Report; Severities; Specimen; Sulfur Dioxide; Sulfurous Anhydride; Susceptibility; Symptoms; TLR3; TLR3 protein, human; TLR3 receptor; Testing; Toll-Like Receptor 3; Toll-like receptor 3, human; United States; Upper Respiratory Infections; Upper Respiratory Tract Infection; Vehicle Emissions; Vehicular Emissions; Viral; Viral Burden; Viral Diseases; Viral Load; Viral Load result; Viral Receptor; Virus; Virus Diseases; Virus Receptors; Viruses, General; Visit; Wheezing; Wheezings; Work; airway epithelium infalmmation; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway inflammation; base; beta-Lipoproteins; biological adaptation to stress; biomarker; child trafficking; children; cohort; cost; cytokine; disease/disorder; drug/agent; endothelial cell derived relaxing factor; enroll; experience; falls; fluid; gene product; human TLR3 protein; improved; inflammatory marker; insight; irrigation therapy; isoprostaglandin F2alpha type-III; lavage therapy; liquid; lower respiratory tract; lung function; mRNA; oxidant stress; particle; pathophysiology; pathway; pollutant; prospective; protein expression; public health medicine (field); public health relevance; pulmonary; reaction; crisis; receptor; recruit; respiratory; respiratory function; respiratory tract; respiratory virus; response; reverse transcriptase PCR; screening; screenings; social role; stress response; stress; reaction; trafficking; urinary; vehicular exhaust; viral infection; virus infection; wheeze; youngster",Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children," Project Narrative: Relevance to Public Health This project will evaluate the impact on the health of asthmatic children of two very common ""real world"" asthma triggers: air pollution (especially diesel and vehicular exhaust) and respiratory viral infections. Enhanced knowledge of the extent and mechanisms of the interactions of these triggers will: a) give a more complete view of the public health impact of air pollution, facilitating scientifically-based air quality and traffic emissions policy; and b) enhance our understanding of the pathophysiology of asthma, a complex disease affecting 22.2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches.",16769,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",A1,1,655726,
7784697,R01,ES,1,,01/14/2010,11/30/2010,PA-07-070,1R01ES017272-01A1,,NIEHS:537116;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,PROVIDENCE,UNITED STATES,PATHOLOGY,01,001785542,US,RI,02912,BROWN UNIVERSITY,"BOEKELHEIDE, KIM ;",1881054;,1R01ES017272,01/14/2010,11/30/2014,"(17Beta)-17-hydroxyandrost-4-en-3-one; (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol; 1,2-Benzenedicarboxylic acid, dibutyl ester; 17-beta-Hydroxy-4-Androsten-3-one; 3-Hexene,3,4-bis(p-hydroxyphenyl)-; 4,4'-Dihydroxy-alpha,beta-diethylstilbene; Acnestrol; Address; Alpha,alpha'-diethylstilbenediol; Androst-4-en-17beta-ol-3-one; Animal Model; Animal Models and Related Studies; Antigestil; Apstil; Assay; Attention; Bioassay; Biologic Assays; Biological Assay; Birth Defects; Bufon; Butyl Phthalate; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chemical Exposure; Common Rat Strains; Comparative Biology; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cryptorchidism; Cryptorchism; Defect; Delta4-androsten-17beta-ol-3-one; Developed Countries; Developed Nations; Development; Developmental Process; Di-n-Butyl Phthalate; Diastyl; Dibutyl Phthalate; Diethylstilbenediol; Diethylstilbestrol; Diethylstilbestrolum; Disease; Disorder; Distilbene; Domestrol; Dose; Employee Strikes; Endocrine; Endocrine Disrupter; Endocrine Disrupting Chemicals; Endocrine Disruptors; Endocrine disrupting agent; Endocrine disruption; Environment; Environmental Exposure; Environmental Pollution; Enzymes; Estrobene; Estrosyn; Event; Exposure to; Fetus; Fonatol; Gene Expression; Genes; Genital System, Male, Testis; Germ Cell Cancers; Goals; Grafestrol; Heterograft; Hormonal; Human; Human, General; Hyperplasia; Hyperplastic; Hypospadia; Hypospadias; Implant; In Vitro; Industrialized Countries; Industrialized Nations; Interstitial Cell of Leydig; Interstitial Cell of the Testis; Laboratories; Leydig Cells; Makarol; Malignant Germ Cell Tumor; Malignant Neoplasm of the Germ Cell; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Messenger RNA; Methods; Mice; Microest; Milestrol; Modeling; Molecular; Molecular Genetic Abnormality; Murine; Mus; Nature; Neo-Oestronol I; Oestrogenine; Oestromenin; Oestromensyl; Oestromon; Palestrol; Pathway interactions; Perinatal; Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-; Plasticizers; Predisposition; Prevalence; Proteins; RNA, Messenger; Rat; Rattus; Reporting; Resistance; Risk Assessment; Rodent; Rodentia; Rodentias; Serral; Sexocretin; Sinestrol; Species Specificity; Sperm Count; Sperm Count Procedure; Sperm Numbers; Steroid biosynthesis; Stilbene Estrogen; Stilbestrol; Stilbetin; Stilboefral; Stilboestroform; Stilkap; Strikes; Strikes, Employee; Structure of interstitial cell of Leydig; Subcellular Process; Susceptibility; Synestrin; Synthoestrin; System; System, LOINC Axis 4; Testicles; Testicular Dysgenesis Syndrome; Testicular Interstitial Cells; Testing; Testis; Testis, Undescended; Testosterone; Therapeutic Testosterone; Trans-Testosterone; Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3; Transplantation; Transplantation, Heterologous; Vagestrol; Work; Xenograft; Xenograft procedure; Xenotransplantation; biomarker; diethylstilbesterol; disease/disorder; endocrine disrupting; endocrine disrupting compound; environmental contaminant; environmental contamination; external genitalia; falls; fetal; gene product; human male; in utero; in vivo; leydig interstitial cell; mRNA; male; model organism; mono-n-butyl phthalate; monobutyl phthalate; pathway; phthalates; public health relevance; reproductive; reproductive development; resistant; response; steroidogenesis; toxicant; transplant; undescended testicles",Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption," 7. PROJECT NARRATIVE Increases in human male reproductive tract abnormalities (falling sperm counts, hypospadias, cryptorchidism, and testis germ cell cancer) have been blamed on environmental exposures that alter the in utero and perinatal hormonal milieu. This project will develop a xenograft bioassay consisting of fetal testes implanted in a rodent host to directly assess human susceptibility to endocrine disrupting chemicals, including the plasticizer di-n-butyl phthalate.",17272,ZRG1,Special Emphasis Panel,A1,1,537116,
7792667,R01,ES,1,,01/07/2010,11/30/2010,PA-07-070,1R01ES017286-01A2,,NIEHS:331688;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,LITTLE ROCK,UNITED STATES,,02,002593692,US,AR,72202,ARKANSAS CHILDREN'S HOSPITAL RES INST,"GILBERT, KATHLEEN M;",1945437;,1R01ES017286,01/07/2010,11/30/2012,"2ar peptide; ATGN; Acute; Adoptive Transfer; Affect; Allergy; Antibodies; Antigens; Apoptosis; Apoptosis Pathway; Autoimmune; Autoimmune Diseases; Autoimmune Hepatitis; Autoimmune Process; Autoimmune Status; Autoimmunity; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell surface; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chronic; Dendritic Cells; Development; Disease; Disorder; Environmental Pollutants; Eta-1 protein; Eta-1-Op protein; Ethene, trichloro-; Ethinyl Trichloride; Evaluation; Exposure to; Future; Generations; Health; Hepatitis, Autoimmune; Human; Human, General; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hypersensitivity; IFN; INFLM; Immune; Immune system; In Vitro; Individual; Inflammation; Inflammatory; Interferons; Intervention; Intervention Strategies; Job Environment; Job Location; Job Place; Job Setting; Job Site; MMP-7; Mammals, Mice; Man (Taxonomy); Man, Modern; Math Models; Matrilysin; Matrin; Matrix Metalloproteinase-7; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Mice, Transgenic; Murine; Mus; Organic Solvents; Organic solvent product; PUMP-1; Pathway interactions; Population; Process; Production; Relative; Relative (related person); Research; Subcellular Process; T-Cell Activation; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Transgenic Mice; Transgenic Organisms; Trichloroethene; Trichloroethylene; Veiled Cells; Water Pollutants; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; autoimmune disorder; autoreactive T cell; body system, allergic/immunologic; bone sialoprotein 1; bone sialoprotein I; cytokine; design; designing; disease/disorder; drinking water; early T-lympocyte activation-1 protein; experiment; experimental research; experimental study; exposed human population; helper T cell; human exposure; immunogen; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; macrophage; mathematical model; mathematical modeling; metalloproteinase (general); mouse model; organ system, allergic/immunologic; osteopontin; pathway; phosphoprotein I, 2aR; prevent; preventing; public health relevance; remediation; research study; secreted phosphoprotein 1; self recognition (immune); sialoprotein 1; thymus derived lymphocyte; transgenic; work environment; work setting",Determining how trichloroethylene alters CD4+ T cell function," A generalized decrease in CD4+ T cell activation-induced apoptosis could predispose an individual to many different types of hypersensitivity disorders and autoimmune disease. Consequently, demonstrating that a common water pollutant such as trichloroethylene can cause this effect and describing the mechanism for it could have important implications for human health.",17286,ZRG1,Special Emphasis Panel,A2,1,331688,
7788064,R01,ES,1,,01/26/2010,12/31/2010,PA-07-070,1R01ES017425-01A1,,NIEHS:423869;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,IOWA CITY,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"LEHMLER, HANS-JOACHIM  (contact);LEIN, PAMELA J;PESSAH, ISAAC N;",1935511;7371642 (contact);8462693;,1R01ES017425,01/26/2010,12/31/2014,"Abnormal Assessment of Metabolism; Address; Ammon Horn; Binding; Binding (Molecular Function); Biochemical; Biotransformation; Body Tissues; CPB6; CYP; CYP2B; CYP2B6 protein, human; CYPIIB6; Ca Release Channel-Ryanodine Receptor; Calcium-Ryanodine Receptor Complex; Chlorine; Cl element; Co-culture; Cocultivation; Coculture; Coculture Techniques; Common Rat Strains; Complex; Cornu Ammonis; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytochrome P450 2B6; Cytochrome P450 CYP2B6; Cytochrome P450 Family 2 Subfamily B Polypeptide 6; Cytochromes; Data; Development; Dose; Elements; Enzymes; Exhibits; Exposure to; FK506-Binding Protein 1; FK506-Binding Protein 1A; FKBP-12; FKBP12; Future; Generalized Growth; Genes; Genetic Polymorphism; Glia; Glial Cells; Goals; Growth; Hippocampus; Hippocampus (Brain); Human; Human, General; IIB1; Immunophilins; In Vitro; Interdisciplinary Research; Interdisciplinary Study; Intermediary Metabolism; Intravenous; Investigation; Isoforms; Kolliker's reticulum; Light; Link; Liver; METBL; Macrophilin-12; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Metabolic Biotransformation; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Mice; Microsomes; Molecular; Molecular Interaction; Molecular Transport; Morphology; Multidisciplinary Collaboration; Multidisciplinary Research; Murine; Mus; Mutagenesis, Site-Directed; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurodevelopmental Disorder; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Organ System; Neurological Development Disorder; Neurons; Non-neuronal cell; Oral; Outcome; P450; P450 IIB1; PCBs; Parents; Perinatal; Perinatal Exposure; Pesticides; Photoradiation; Plasticizers; Polychlorinated Biphenyls; Polychlorobiphenyl Compounds; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Process; Protein Isoforms; Public Health; Rat; Rattus; Receptors, Ryanodine; Recombinants; Research; Risk; Role; RyR1; RyR2; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Slice; Study, Interdisciplinary; Susceptibility; Tacrolimus Binding Protein 1A; Targeted DNA Modification; Targeted Modification; Testing; Tissue Growth; Tissues; Toxic effect; Toxicities; Transport Process; base; body system, hepatic; chlorine gas; clinical relevance; clinically relevant; cytochrome P-450 CYP2B6; cytochrome P-450 CYP2B6 (human); developmental neurotoxicity; enantiomer; environment effect on gene; exposed human population; fetal exposure; gene environment interaction; hippocampal; human CYP2B6 protein; human exposure; in utero exposure; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; insight; intra-uterine environmental exposure; intrauterine environmental exposure; metabolic abnormality assessment; nerve cement; neuron toxicity; neuronal; neuronal toxicity; neurotoxicity; novel; offspring; ontogeny; organ system, hepatic; pharmacokinetic model; pollutant; polychlorobiphenyl; polymorphism; pregnant; protein expression; public health medicine (field); public health relevance; receptor binding; receptor expression; social role",Enantioselective Metabolism Influences PCB Developmental Neurotoxicity," RELEVANCE TO PUBLIC HEALTH Developmental exposures to chiral polychlorinated biphenyls (PCBs) may cause neurodevelopmental toxicity by interfering with dendritic growth and plasticity via mechanisms involving the enantiospecific sensitization of ryanodine receptors. The goal of the proposed research is to investigate how differences in the enantioselective disposition of chiral PCBs in pregnant mice influence neurodevelopmental endpoints in exposed offspring. Because the enantiomer ratio of chiral PCBs is highly variable in human populations, the proposed studies will make a fundamental contribution to understanding the risk associated with human exposure to chiral PCB congeners that are highly toxic to the developing nervous system and will provide an insight into the role of chirality in the disposition and toxicity of a broad range of other organic pollutants, such as many pesticides and plasticizers.",17425,ZRG1,Special Emphasis Panel,A1,1,423869,
7765814,R01,ES,1,,02/01/2010,11/30/2010,PA-07-070,1R01ES017764-01,,NIEHS:470593;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,MILWAUKEE,UNITED STATES,PEDIATRICS,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"MCCARVER, D GAIL;",6670349;,1R01ES017764,02/01/2010,11/30/2013,"0-11 years old; 0-6 weeks old; 18 year old; 21+ years old; 4,4' isopropylidinediphenol; Address; Adult; Adverse effects; Age; Age-Months; Alleles; Allelomorphs; Animals; Assay; Attention; Behavioral; Bioassay; Biologic Assays; Biologic Monitoring; Biological Assay; Biological Monitoring; Blood; Chemicals; Child; Child Youth; Children (0-21); Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Computers; Data; Development; Dose; Enzymes; Epoxy Resins; Evaluation; Exhibits; Fetal Age; Fetal Maturity, Chronologic; Fetus; Food; Food Container; Gender; Generalized Growth; Genetic; Genetic Polymorphism; Genital System, Male, Prostate; Genotype; Gestation; Gestational Age; Glucuronides; Goals; Government; Gray; Gray unit of radiation dose; Growth; HPLC; Health; Hepatic; High Pressure Liquid Chromatography; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, Child; Human, General; In Vitro; Individual; Industry; Infant; Infant, Newborn; Infant, Newborn, Intensive Care; Intensive Care, Neonatal; Intermediary Metabolism; Life; Light; Literature; Liver; Liver Microsomes; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Math Models; Measurable; Measures; Medical Device; Metabolic; Metabolic Processes; Metabolism; Mice; Microsomes, Liver; Modeling; Monitoring, Biological; Mothers; Murine; Mus; Neonatal; Neonatal Intensive Care; Nervous; Newborn Infant; Newborns; Oral; Outcome; Pathway interactions; Pattern; Photoradiation; Physiologic; Physiological; Plant Resins; Policy Maker; Polymorphism (Genetics); Polymorphism, Genetic; Population; Postpartum Women; Pregnancy; Production; Prostate; Prostate Gland; Prostatic Gland; Public Health; Publishing; Relative; Relative (related person); Reporting; Resins, Plant; Reticuloendothelial System, Blood; Risk; Risk Assessment; Sampling; Sound; Sound - physical agent; Source; Testing; Tissue Growth; Toxic effect; Toxicities; Transcript; Treatment Side Effects; Urinary System, Urine; Urine; Woman; Women, Postpartum; Work; adult human (21+); biomonitoring; bisphenol A; body system, hepatic; children; cohort; diphenylolpropane; eighteen year old; exposed human population; feeding; fetal; human data; human exposure; improved; in vivo; infancy; infantile; longitudinal design; mathematical model; mathematical modeling; neural; newborn human (0-6 weeks); ontogeny; organ system, hepatic; pathway; polycarbonate plastic; polymorphism; postnatal; premature; public health medicine (field); public health relevance; relating to nervous system; reproductive; resin; side effect; sound; subcutaneous; sulfation; therapy adverse effect; treatment adverse effect; urinary; youngster",Factors Determining Bisphenol A Disposition in Human Infants," PROJECT NARRATIVE The proposed work will fill the following data gaps limiting human bisphenol A (BPA) risk assessment: 1) quantification of human newborn BPA exposure and the impact of prematurity and postnatal age on BPA metabolism; 2) determination of whether a common, functional genetic difference in UGT2B15 (the enzyme that metabolizes BPA) is associated with differences in BPA disposition; and 3) characterization of the developmental pattern of UGT2B15 such that physiologic mathematical modeling of BPA A disposition across development can be achieved. Without the results of this study, the vast number of BPA animal studies will remain controversial and of limited risk assessment use. Irrespective of the outcome of the proposed hypotheses testing, the data generated will have significant public health impact and will be used for risk assessment for this high volume, ubiquitous chemical.",17764,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,1,470593,
7789373,R01,ES,1,,01/08/2010,11/30/2010,PA-07-070,1R01ES019313-01,,NIEHS:308250;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,COLUMBIA,UNITED STATES,PATHOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"NAGARKATTI, MITZI ;NAGARKATTI, PRAKASH S. (contact);",1863084;1888448 (contact);,1R01ES019313,01/08/2010,11/30/2014,"(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol; 0-11 years old; 0-6 weeks old; 3-Hexene,3,4-bis(p-hydroxyphenyl)-; 4,4'-Dihydroxy-alpha,beta-diethylstilbene; ATGN; Acnestrol; Age; Alpha,alpha'-diethylstilbenediol; American; Antigens; Antigestil; Apoptosis; Apoptosis Antigen Ligand 1; Apoptosis Pathway; Apstil; Aquadiol; Atrophic; Atrophy; Autoantigens; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Autologous Antigens; Benign; Binding; Binding (Molecular Function); Bufon; CD178 Antigen; CD8; CD8B; CD8B1; CD8B1 gene; CD95 Ligand; CD95 antigen ligand; Cancer of Breast; Cancers; Cell Communication; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell-to-Cell Interaction; Chemicals; Child; Child Youth; Children (0-21); Daughter; Development; Diastyl; Diethylstilbenediol; Diethylstilbestrol; Diethylstilbestrolum; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Distilbene; Domestrol; Drugs; Elements; Endocrine Disrupter; Endocrine Disrupting Chemicals; Endocrine Disruptors; Endocrine disrupting agent; Environment; Environmental Estrogen; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrobene; Estrogen Receptors; Estrogen Replacement Therapy; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrosyn; Exposure to; FTOC; Farm Animal; Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Female; Fetal Thymic Organ Culture; Fonatol; Food; GA-1 Germ Cell Antigen; Generations; Genes; Genes, Class I; Genes, MHC Class I; Germinoblastoma; Gestation; Grafestrol; H-Y Antigen; HY Antigen; Health; Hormone Replacement Rx; Hormone replacement therapy; Human, Child; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immune system; Immunologic Diseases; Immunological Diseases; Immunomodulation; In Vitro; Incidence; Induction of Apoptosis; Infant, Newborn; Infection; LYT3; Lead; Life; Lifetime Risk; Link; Livestock; Livestocks; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MHC Class I; MHC Class I Genes; MHC Receptor; Major Histocompatibility Complex Receptor; Makarol; Malignant Neoplasm of the Uterus; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Uterus; Malignant Uterine Neoplasm; Malignant Uterine Tumor; Malignant neoplasm of breast; Mammals, Mice; Mature T-Cell; Mature T-Lymphocyte; Mediating; Medication; Menopausal Symptom; Mice; Mice, Transgenic; Microest; Milestrol; Miscarriage; Molecular Interaction; Mothers; Murine; Mus; NF-AT proteins; NFAT proteins; NFATC proteins; Neo-Oestronol I; Newborn Infant; Newborns; Nuclear; Oestrogenine; Oestromenin; Oestromensyl; Oestromon; Ovarian Tumor; Ovary Neoplasms; Ovocyclin; Ovocylin; Palestrol; Pb element; Pesticides; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-; Physiologic; Physiological; Phyto-Estrogen; Phytoestrogens; Plants; Plants, General; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Predisposition; Pregnancy; Premature Birth; Preterm Birth; Prevention; Progynon; Receptors, Antigen, T-Cell; Regulation; Reporting; Research; Reticuloendothelial System, Thymus; Reticulolymphosarcoma; Risk; Role; Sarcoma, Germinoblastic; Self-Antigens; Serral; Sexocretin; Sinestrol; Son; Spontaneous abortion; Stilbene Estrogen; Stilbestrol; Stilbetin; Stilboefral; Stilboestroform; Stilkap; Stromal Cells; Susceptibility; Synestrin; Synthetic Estrogens; Synthoestrin; T-Cell Receptor; T-Cells; T-Lymphocyte; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Toxic effect; Toxicities; Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Transgenic Organisms; Tumor Necrosis Factor Ligand Superfamily Member 6; Tumor of the Ovary; Uterine Cancer; Uterus Cancer; Vagestrol; Woman; autoimmune disorder; body system, allergic/immunologic; cancer type; children; diethylstilbesterol; disease/disorder; drug/agent; endocrine disrupting compound; feeding; heavy metal Pb; heavy metal lead; immune modulation; immunogen; immunologic reactivity control; immunoregulation; immunotoxicity; in utero; in vivo; insight; male; malignancy; malignant breast neoplasm; men; men's; neoplasm/cancer; newborn human (0-6 weeks); novel; nuclear factor of activated T-cells, cytoplasmic; nuclear factors of activated T-cells; offspring; organ system, allergic/immunologic; ovarian neoplasm; post-menopausal; postmenopausal; postnatal; premature childbirth; premature delivery; prenatal; prenatal exposure; prenatally exposed; preterm delivery; prevent; preventing; public health relevance; pup; reproductive; response; self recognition (immune); sex determinant antigen; social role; soy; surfactant; synthetic estrogenic compound; thymocyte; thymus derived lymphocyte; toxic reaction in immunology; transcription factor; transcription factor NF-AT; transgenic; tumor; unborn; xenoestrogen; youngster",Estrogen-T cell Interactions," There has been a high incidence of cancers as well as autoimmune diseases observed in women who were prescribed during pregnancy, a synthetic estrogen known as diethylstibestrol, as well as in their sons and daughters. Postmenopausal women administered estrogens in hormone replacement therapy, as well as, several chemicals found in the environment and foods act as estrogens causing significant health problems. Thus, our studies are aimed at providing insights into the mechanism by which estrogens mediate their toxic effects on the immune system, thereby leading to the development of strategies for their prevention and treatment.",19313,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,1,308250,
7782389,R01,EY,1,Y,01/18/2010,12/31/2010,PA-07-070,1R01EY019152-01A2,,NEI:612145;,2010,NATIONAL EYE INSTITUTE,,CAMBRIDGE,UNITED STATES,MISCELLANEOUS,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"SUR, MRIGANKA ;",1876335;,1R01EY019152,01/18/2010,12/31/2010,"Acute; Address; Affect; Amblyopia; Anterior Quadrigeminal Body; Area striata; Area striata structure; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Behavior; Behavioral; Binocular Disparity; Binocular Vision; Blindness; Blood Coagulation Factor IV; Ca++ element; Calcium; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Coagulation Factor IV; Cognition Disorders; Contralateral; Corpora quadrigemina, superior colliculus; Cortex, Striate; Data; Development; Dominance, Ocular; Dorsal; Dysfunction; EPH; Eph Family Receptors; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Exhibits; Eye; Eye Dominance; Eyeball; FOS gene; Factor IV; Fixation Disparity; Functional disorder; G0S7; Generations; Genes; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Ipsilateral; Kanner's Syndrome; Knock-out; Knockout; Knockout Mice; Lateral Geniculate Body; Lead; Link; Location; Mammals, Mice; Maps; Mediating; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Murine; Mus; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Null Mouse; Ocular Disparity; Ocular Dominance; Ocular dominance columns; Optic Tectum; Parallax, Ocular; Pattern; Pb element; Phenotype; Phorias; Physiologic; Physiological; Physiopathology; Position; Positioning Attribute; Primary visual cortex; Process; Protooncogene FOS; Receptors, Eph Family; Relative; Relative (related person); Retina; Retinal; Retinal Disparity; Role; Sensory Process; Shapes; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Social Development; Specific qualifier value; Specified; Squint; Strabismus; Striate area; Structure; Superior Colliculus; Tag; Techniques; Tectums, Optic; Testing; Tracer; Transmembrane Protein; Vision; Vision Disorders; Vision Disparity; Vision, Binocular; Visual; Visual Cortex; Visual Disorder; Visual Disparity; Visual Pathways; Work; area striata; axon growth cone guidance; axon guidance; base; biological signal transduction; c fos; c-fos Gene; c-fos Proto-Oncogenes; cognitive disease; cognitive disorder; design; designing; emx2; emx2 gene product; emx2 protein; emx2 protein, vertebrate; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; imaging; in vivo; intervention design; lateral geniculate; lateral geniculate nucleus; monocular; mutant; neuronal; novel; optic imaging; optical imaging; pathophysiology; public health relevance; receptive field; research study; response; social role; superior colliculus Corpora quadrigemina; therapy design; treatment design; two-photon; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; vision development; visual cortical; visual development; visual process; visual processing; visual system development; visual tectum",Molecular and functional mechanisms underlying binocular vision,"Narrative Ten_m3 has been shown to be instrumental in development of the visual system. Improper processing of visual inputs can result in amblyopia, strabismus, or blindness; in addition, deficits in sensory processing have been linked to autism and other disorders of cognitive and social development. The planned experiments promise to elucidate the mechanisms by which Ten_m3 expression affects the development of binocular vision, and thus to provide a novel basis for the design of therapies for visual dysfunction.",19152,CVP,Central Visual Processing Study Section,A2,1,612145,
7767142,R01,EY,1,,02/01/2010,01/31/2011,PA-07-070,1R01EY019869-01,,NEI:527219;,2010,NATIONAL EYE INSTITUTE,,LA JOLLA,UNITED STATES,OPHTHALMOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"SAMPLE, PAMELA A;",1902551;,1R01EY019869,02/01/2010,01/31/2015,"Accounting; Active Follow-up; Address; African; African American; Afro American; Afroamerican; Age; Alabama; Algorithms; Black Populations; Black or African American; Blindness; California; Caring; Characteristics; Clinical; Clinical Research; Clinical Study; Cohort Studies; Concurrent Studies; Cornea; Cranial Nerve II; Cranial Nerve II Diseases; Cranial Nerve II Disorder; Data; Data Collection; Data Coordinating Center; Data Coordination Center; Detection; Development; Diagnosis; Diagnostic; Diagnostic tests; Disease; Disease Progression; Disorder; Disorder of the optic nerve; Doctor of Medicine; Doctor of Philosophy; Drugs; Dysfunction; Ear; Ear structure; Effectiveness; Enrollment; European; Evaluation; Evaluation Studies; Event; Eye; Eyeball; Functional Imaging; Functional disorder; Funding; Glaucoma; Goals; History; Image; Imaging Device; Imaging Tool; Individual; Intervention; Intervention Strategies; Investigators; Knowledge; Length; Literature; Longitudinal Studies; M.D.; Manuals; Measurement; Measures; Medication; Methods; Minority; Modeling; Monitor; Natural History; Nerve Fibers; Neural-Optical Lesion; New York; Ophthalmology; Optic Disk; Optic Nerve; Optic Nerve Diseases; Optic Nerve Head; Optic Neuropathy; Optic Papilla; POAG; Partial Sight; Participant; Patients; Pattern; Perimetry; Persons; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic Imaging; Physiopathology; Population; Prevalence; Primary Open Angle Glaucoma; Procedures; Process; Progressive Disease; Prospective Studies; Protocol; Protocols documentation; Race; Racial Group; Reading; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Researchers; Retina; Retinal; Risk; Risk Factors; SUBGP; Saint Lucia; Sample Size; Sampling; Second Cranial Nerve; Second Cranial Nerve Diseases; Severity of illness; Sight; Site; Specialist; St. Lucia; Staging; Stocks, Racial; Stress; Structure; Study Type; Subgroup; Testing; Thick; Thickness; Time; Universities; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visit; Visual; Visual Fields; Visual impairment; base; black American; cohort; computer based prediction; corneal; cost; design; designing; disease severity; disease/disorder; drug/agent; enroll; follow-up; glaucomatous; high risk; imaging; improved; innovate; innovation; innovative; interventional strategy; long-term study; meetings; optic nerve disorder; pathophysiology; patient population; population based; predictive modeling; prospective; public health relevance; retinal nerve fiber layer; second cranial nerve disorder; study design; tool; visually impaired",African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma Progression," African Descent and Glaucoma Evaluation Study (ADAGES) II: Progression Project Narrative  Glaucoma is four to five times more likely to occur in persons of African descent, up to fifteen times more likely to cause meaningful visual impairment in this group compared to those of European descent, and the leading cause of blindness in African Americans. ADAGES II will develop models to predict which individuals are most at risk for progression of glaucoma using knowledge gained about the factors associated with change in visual function and retinal structure, including ancestry, stage of disease, and rate of change. This will provide clinicians with critical information currently not known or well understood, information that will substantially improve the effectiveness of individualized treatment for this potentially blinding disease.",19869,ZEY1,Special Emphasis Panel,,1,527219,
7766070,R01,EY,1,,02/01/2010,01/31/2011,PA-07-070,1R01EY019904-01,,NEI:627293;,2010,NATIONAL EYE INSTITUTE,,BALTIMORE,UNITED STATES,OPHTHALMOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HANDA, JAMES T;",1902592;,1R01EY019904,02/01/2010,01/31/2014,"ATF; Acids; Acquired Blindness; Active Oxygen; Address; Age; Age related macular degeneration; Aged 65 and Over; Aging; Antioxidants; Apoptosis; Apoptosis Pathway; Basic Leucine Zipper; Binding; Binding (Molecular Function); Blindness; Cell Communication and Signaling; Cell Death, Programmed; Cell Protection; Cell Signaling; Chemicals; Chronic; Clinical Trials, Phase I; Complement Activation; Cytoprotection; Data; Deposit; Deposition; Development; Disease; Disorder; Dysfunction; Early treatment; Early-Stage Clinical Trials; Elderly; Elderly, over 65; Enhancers; Enzymes; Epidemiology; Event; Functional disorder; Fundus; Gene Transcription; Genes; Genetic; Genetic Transcription; Injury; Intracellular Communication and Signaling; Link; Macular degeneration; Macular degenerative disease; Maculopathy, Age-Related; Mammals, Mice; Measures; Mediating; Medicine; Mice; Molecular Interaction; Murine; Mus; NF-E2 protein; NF-E2 transcription factor; NFE2 protein; Nuclear; Onset of illness; Outcome; Outer pigmented layer of retina; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; Patients; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phenotype; Physiopathology; Pigment cell layer of retina; Pigmented layer of retina; Prevention; Pro-Oxidants; RNA Expression; Reactive Oxygen Species; Redox; Regulation; Response Elements; Retina; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Risk Factors; Role; Science of Medicine; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Smoke; Smoking; Solid; Stimulus; Structure of retinal pigment epithelium; System; System, LOINC Axis 4; Testing; Transcription; Transcription, Genetic; United States; Wild Type Mouse; activating transcription factor; advanced age; air filter; anti-oxidant; bZIP Domain; biological adaptation to stress; biological signal transduction; cell type; cigarette smoke; cigarette smoke-induced; cigarette smoking; complement pathway; complement pathway regulation; disease onset; disease/disorder; disorder onset; elders; electron acceptor; experiment; experimental research; experimental study; gain of function; geriatric; inhibitor; inhibitor/antagonist; late life; later life; loss of function; mouse model; neovascular; nuclear factor-erythroid 2; older adult; older person; oxidant stress; oxidation reduction reaction; oxidative damage; pathophysiology; phase 1 study; phase 1 trial; phase I trial; prevent; preventing; protocol, phase I; public health relevance; reaction; crisis; research study; response; senescent; senile macular disease; senior citizen; small molecule; smoke cigarette; smoke of cigarettes; social role; stress response; stress; reaction; stressor; transcription factor; treatment strategy",Nrf2 signaling and oxidative stress in Age-related macular degeneration," Project Narrative Age-related macular degeneration is now the most common cause of blindness among the elderly in the United States, yet our understanding of how early disease develops is limited. Cigarette smoking is the strongest risk factor associated with AMD yet we do not understand how it causes disease onset or progression. This proposal will study how cigarette smoking triggers the onset of macular degeneration. Experiments will explore if Nuclear factor-erythroid 2-related factor 2 (Nrf2), a transcription factor that activates antioxidant and cytoprotective enzymes, protects against cigarette smoke induced oxidative stress and complement activation. This proposal will also explore whether triterpenoids, or small molecules that can activate Nrf2, will prevent the development of AMD in mouse models.",19904,BDPE,Biology and Diseases of the Posterior Eye Study Section,,1,627293,
7769011,R01,EY,1,,02/01/2010,01/31/2011,PA-07-070,1R01EY019924-01,,NEI:386607;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"MERABET, LOTFI ;",8679590;,1R01EY019924,02/01/2010,01/31/2015,"0-11 years old; 21+ years old; Adult; Ammon Horn; Area; Auditory; Award; Basic Research; Basic Science; Behavioral; Biological Neural Networks; Blindness; CNS plasticity; Child; Child Youth; Children (0-21); Clinical; Cognitive; Computer Programs; Computer software; Computers; Cornu Ammonis; Cues; Destinations; Development; Effectiveness; Environment; Evaluation; Eye; Eyeball; Functional Magnetic Resonance Imaging; Generations; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, Child; Human, General; Image; Individual; Investigative Technics; Investigative Techniques; Knowledge; Laboratories; Lead; Learning; MRI, Functional; Magnetic Resonance Imaging, Functional; Magnetism; Man (Taxonomy); Man, Modern; Maps; Methods; Methods and Techniques; Methods, Other; Motor; Nervous; Neurobiology; Neuronal Plasticity; Neurosciences; Neurosciences Research; Occipital lobe; Outcome Measure; Parietal; Partial Sight; Participant; Pb element; Performance; Phase; Physical Health Services / Rehabilitation; Physical environment; Principal Investigator; Process; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Route; Scientist; Sensory; Sensory Process; Sight; Simulate; Software; Structure; Task Performances; Techniques; Testing; Time; Training; Training of Investigators; Transcranial magnetic stimulation; Transference; Transference (Psychology); Translating; Translatings; Travel; Video Games; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual; Visual impairment; Visually Impaired Persons; adult human (21+); application in practice; base; blind; blind individual; blind people; blind person; career; children; cognitive neuroscience; compare effectiveness; computer center; computer program/software; experience; experiment; experimental research; experimental study; fMRI; heavy metal Pb; heavy metal lead; hippocampal; imaging; indexing; insight; interest; investigator training; language translation; magnetic; neural; neural mechanism; neural network; neural plasticity; neurobiological; neuroimaging; neuromechanism; neuroplasticity; new approaches; novel; novel approaches; novel strategies; novel strategy; occipital cortex; practical application; primary outcome; public health relevance; rehabilitative; relating to nervous system; research study; skills; spatial navigation; spatial relationship; translational neuroscience; virtual; visually impaired; visually impaired people; way finding; wayfinding; youngster",Audio Based Navigation in the Blind, Project Narrative We propose to investigate cognitive spatial mapping skills in the blind through virtual navigation of real-world environments using a computer-based software approach. The results of this study will contribute new insights towards our understanding of the neural mechanisms associated with navigation and develop novel approaches for orientation and mobility training in the blind.,19924,ZRG1,Special Emphasis Panel,,1,386607,
7770341,R01,EY,1,,02/01/2010,01/31/2011,PA-07-070,1R01EY019943-01,,NEI:456690;,2010,NATIONAL EYE INSTITUTE,,BAR HARBOR,UNITED STATES,,02,042140483,US,ME,046091500,JACKSON LABORATORY,"CHANG, BO ;",2094860;,1R01EY019943,02/01/2010,01/31/2015,"Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Authorization; Authorization documentation; Award; Biological Models; Candidate Disease Gene; Candidate Gene; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Charge; Collection; Communities; DNA; DNA Markers; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Deoxyribonucleic Acid; Development; Disease; Disorder; Electronics; Electroretinography; Engineering; Engineerings; Ensure; Environment; Exhibits; Expertise, Technical; Expression Profiling; Expression Signature; Eye; Eye diseases; Eyeball; Fees; Future; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genotype; Goals; Grant; Human; Human, General; In Situ; Inbred Strain; Institutes; Investigators; Laboratories; Literature; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Model System; Modeling; Models, Biologic; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutant Strains Mice; Mutation; Nature; OMIM; Online Mendelian Inheritance In Man; Ophthalmoscopy; Pathway interactions; Permission; Phenotype; Physiology; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; Recovery; Research; Research Personnel; Research Resources; Researchers; Resources; Retinal; Retinal Diseases; Retinal Disorder; Retinal Neovascularization; Role; Science of Anatomy; Scientific Publication; Scientist; Screening procedure; Services; Site; Structure; Study models; Subcellular Process; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Technical Expertise; Techniques; Testing; Therapeutic; Time; Update; Variant; Variation; Vision research; Work; anatomy; animal care; biomarker; clinical data repository; clinical data warehouse; clinical phenotype; clinical relevance; clinically relevant; cost; data repository; disease phenotype; disease/disorder; electroretinogram; eye disorder; genome mutation; human disease; improved; information gathering; interest; meetings; model organism; molecuar profile; molecular signature; mouse model; mouse mutant; mutant; neovascularization; novel; ophthalmopathy; pathway; programs; public health relevance; relational database; repository; retina disease; retina disorder; retinopathy; screening; screenings; social role; success; tool; web site",Eye Mutant Resource," Public Health Relevance  Models to study eye diseases that occur in humans are important as reproducible experimental systems for elucidating pathways of normal development and function. Further, these models can be used to identify treatment targets and to test therapeutic strategies. The EMR focuses on identifying, characterizing and distributing such models.",19943,ZRG1,Special Emphasis Panel,,1,456690,
7785960,R01,GM,1,,01/15/2010,12/31/2010,PA-07-070,1R01GM087575-01A1,,NIGMS:297502;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,ANATOMY/CELL BIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"KREITZER, GERI E;",1897021;,1R01GM087575,01/15/2010,12/31/2014,"Absorption; Actins; Adherens Junction; Adhering Junction; Adhesive Junction; Anchoring Junction; Animals; Apical; Assay; Automobile Driving; Autoregulation; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biosensor; Body Tissues; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Polarity; Cell Signaling; Cell membrane; Cell surface; Cells; Cellular Expansion; Cellular Growth; Cyst, Pilar; Cytoplasmic Membrane; Data; Defect; Destinations; Development; Disease; Disorder; Drivings, Automobile; Ensure; Environment; Epidermal Cyst; Epidermal Inclusion Cyst; Epidermoid Cyst; Epithelial; Epithelial Cells; Epithelial cyst; Epithelium; Event; Family; Goals; Golgi; Golgi Apparatus; Golgi Complex; Growing End of the Microtubule; Homeostasis; Horn Cyst; Human Pathology; Hybrids; Inclusion Cyst; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Keratin Cyst; Keratinizing Cyst; Keratinous Cyst; Kinesin; Lead; Life; Maintenance; Maintenances; Malabsorption Syndromes; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediating; Membrane; Membrane Protein Traffic; Membrane Proteins; Membrane Traffic; Membrane Transport; Membrane Transport Proteins; Membrane Transporters; Membrane-Associated Proteins; Methods; Micro-tubule; Microtubule Stabilization; Microtubules; Mitotic spindle; Modification; Molecular; Molecular Interaction; Motor; NGFR; NGFR gene; Organ; Organ System; Organism; Outcome; Pb element; Photometry/Spectrum Analysis, Mass; Physiological Homeostasis; Plasma Membrane; Play; Plus End of the Microtubule; Process; Process of absorption; Proteins; Reagent; Regulation; Role; Route; Scaffolding Protein; Sebaceous Cyst; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Surface Proteins; System; System, LOINC Axis 4; TNFRSF16; Testing; Therapeutic Intervention; Tissues; Transmembrane Transport; Transport Vesicles; VESCL; Vesicle; Yeasts; absorption; apical membrane; base; biological signal transduction; body system; cardiovascular disorder; cell cortex; cell growth; cellular polarity; disease/disorder; driving; fungus; gastrointestinal absorption disorder; gene product; heavy metal Pb; heavy metal lead; interest; intervention therapy; interventional strategy; intestinal malabsorption; knock-down; living system; malabsorption; malignancy; member; membrane structure; mutant; neoplasm/cancer; new therapeutic target; p75; p75 transcription factor; p75(NTR); plasmalemma; polarized cell; public health relevance; response; sensor (biological); social role; trafficking; transcriptional coactivator p75; yeast protein",Kinesin function and regulation during epithelial polarization," Project Narrative Polarized epithelial cells play a key role in maintaining internal homeostasis by acting as a barrier between the outside environment and internal organs. Our long-term goal is to understand, at molecular and mechanistic levels, how epithelial cells develop structural and functional asymmetry, a process critical to the normal function of tissues comprised of these cells. Indeed, loss of epithelial polarity is associated with a variety of human pathologies including cancers of diverse tissue origin, cystic diseases and malabsorption and secretory disorders in several organ systems. Elucidation of molecular events driving polarization is important, not only for understanding normal development, but also because the details of this process will enable us to develop therapeutic intervention strategies targeting diseases associated with loss of epithelial polarity.",87575,ZRG1,Special Emphasis Panel,A1,1,297502,
7791799,R01,GM,1,,01/20/2010,12/31/2010,PA-07-070,1R01GM088237-01A1,,NIGMS:327703;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,CHEMISTRY,08,082359691,US,MA,02138,HARVARD UNIVERSITY,"RITTER, TOBIAS ;",8964381;,1R01GM088237,01/20/2010,12/31/2014,"Acids; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Applications Grants; Area; C element; Carbon; Chemicals; Complex; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; F element; Fluorides; Fluorine; Goals; Grant Proposals; Grants, Applications; Idiopathic Parkinson Disease; Lewy Body Parkinson Disease; Ligands; Mediating; Medical Imaging, Positron Emission Tomography; Mental Depression; Methods; Molecular; Organometallic Chemistry; PET; PET Scan; PET imaging; PETSCAN; PETT; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Parkinsonism; Primary Senile Degenerative Dementia; Property; Property, LOINC Axis 2; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Reaction; Reagent; Research; Schizophrenia; Schizophrenic Disorders; Science; Silanes; Source; Staging; Tag; Tracer; Transition Elements; base; dementia of the Alzheimer type; dementia praecox; drug development; functional group; metal complex; molecular imaging; paxil; prevent; preventing; primary degenerative dementia; public health relevance; schizophrenic; senile dementia of the Alzheimer type; silane; transition metal",Organometallic Chemistry for Applications in Biomedical Sciences," Relevance Many of the most useful man-made molecules contain fluorine due to the unique, desired properties of fluorinated molecules. The current inability of chemists to make complex fluorinated molecules by late-stage fluorination often prevents research in diverse areas such as drug development and molecular PET imaging.",88237,SBCB,Synthetic and Biological Chemistry B Study Section,A1,1,327703,
7783899,R01,HD,1,,02/01/2010,01/31/2011,PA-07-070,1R01HD058886-01A2,,NICHD:671485;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"GRANT, STRUAN F.A.;ZEMEL, BABETTE S (contact);",3099834 (contact);8757369;,1R01HD058886,02/01/2010,01/31/2014,"0-11 years old; 12-20 years old; 19 year old; 6 year old; Adolescence; Adolescent; Adolescent Youth; Affect; African; African American; Afro American; Afroamerican; Age; Alleles; Allelomorphs; American; Arts; Assay; Behavioral; Bioassay; Biologic Assays; Biological; Biological Assay; Black Populations; Black or African American; Body Size; Bone; Bone Density; Bone Formation; Bone Mineral Contents; Bone Mineral Density; Bone and Bones; Bone remodeling; Bones and Bone Tissue; CNP; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Child health care; Childhood; Children (0-21); Cohort Studies; Collection; Concurrent Studies; Copy Number Polymorphism; Coxa; Data; Data Quality; Development; Diagnosis; Dietary Factors; Dietary intake; Disease; Disorder; Enrollment; Ethnic Origin; Ethnicity; Ethnicity aspects; Event; FLR; Failure (biologic function); Forearm; GWAS; Generalized Growth; Genes; Genetic; Genetic Determinism; Genotype; Goals; Growth; Growth and Development; Growth and Development function; Haplotypes; Health, Child; Height; Hip; Hip region structure; Hispanic Populations; Hispanics; Hispanics or Latinos; Human; Human, Child; Human, General; Institutes; International; Intracellular Communication and Signaling; Laboratories; Latino Population; Lead; Life; Life Cycle; Life Cycle Stages; Linkage Disequilibrium; Linkage Disequilibriums; Longitudinal Studies; Man (Taxonomy); Man, Modern; Maps; Measurement; Measures; Methods and Techniques; Methods, Other; Minerals; Modeling; Nature; Occidental; Osteogenesis; Osteoporosis; Osteoporosis prevention; Outcome; Pathway interactions; Pattern; Pb element; Phase; Physical activity; Population; Population Control; Prepuberal state; Prevention; Procedures; Process; Puberty; Publishing; Quality, Data; Reference Standards; Regulation; Relative; Relative (related person); Research Design; Risk; Risk Factors; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Skeleton; Spanish Origin; Spinal Column; Spine; Staging; Stratification; Study Type; Techniques; Testing; Time; Tissue Growth; Variant; Variation; Vertebral column; Visit; Woman; adolescence (12-20); backbone; base; biological signal transduction; black American; bone; bone health; bone loss; bone mass; bone remodelling; children; cohort; copy number variation; critical period; density; design; designing; disease/disorder; enroll; failure; genetic determinant; genetic variant; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; hispanic community; human puberty; juvenile; juvenile human; life course; long-term study; men; men's; nineteen year old; ontogeny; pathway; pediatric; prepuberty; public health relevance; six year old; skeletal; study design; teenage; trait; white race; whole genome association studies; whole genome association study; youngster",Genome Wide Association Study of Bone Mineral Accretion During Childhood," PROJECT NARRATIVE Osteoporosis, a common condition that affects up to 30% of women and 12% of men, likely has its origins in childhood as a result of inadequate bone mineral accretion. Bone density and risk of osteoporosis have a strong heritable component, but little is known about the genetic determinants of bone mineral status and bone accretion during childhood. This study, in cooperation with the existing NICHD multi-center, multi-ethnic longitudinal Bone Mineral Density in Childhood Study, will conduct a genome wide association study of bone mineral status and bone accretion during childhood in order to identify the genetic determinants of bone health early in life with the ultimate goal of identifying new pathways for osteoporosis prevention.",58886,ZRG1,Special Emphasis Panel,A2,1,671485,
7740563,R01,HD,1,Y,01/11/2010,12/31/2010,PA-07-070,1R01HD059739-01A1,,NICHD:921000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,ROCHESTER,UNITED STATES,GENETICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"MAYER-PROSCHEL, MARGOT ;",6622148;,1R01HD059739,01/11/2010,12/31/2010,"0-11 years old; AD/HD; ADHD; Acoustic Nerve; Address; Affect; Alcoholism; American; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Auditory; Auditory Brainstem Responses; Auditory system; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Behavioral; Brain; Brain Stem; Brainstem; Cell/Tissue, Immunohistochemistry; Cells; Central Nervous System; Child; Child Youth; Children (0-21); Chronic; Clinical; Cranial Nerve Eight; Cranial Nerve VIII; Data; Defect; Demyelinations; Depression; Development; Diagnosis; Diagnostic; Diffuse; Disease; Disorder; Dysfunction; Early Diagnosis; Eighth Cranial Nerve; Electrons; Encephalon; Encephalons; Environmental Toxin; Exposure to; FLR; Failure (biologic function); Fe element; Functional disorder; Generations; Gestation; Hearing; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Hypoxia; Hypoxic; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Impairment; Inflammatory; Injury; Intervention; Intervention Strategies; Iron; Kanner's Syndrome; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Malnutrition; Measurement; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mental Depression; Metabolic; Methods; Microscopic; Modeling; Monitor; Mothers; Myelin; NMR Imaging; NMR Tomography; Negative Beta Particle; Negatrons; Nerve; Nerve Conduction; Nervous; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, Brain; Nervous System, CNS; Neural Conduction; Neuraxis; Neurological Damage; Neurological Injury; Neurological trauma; Nuclear Magnetic Resonance Imaging; Nutritional Deficiency; Oxygen Deficiency; Physiopathology; Population; Pregnancy; Process; Psychoses; Psychotic Disorders; Research; Response Latencies; Responses, Auditory Brainstem; Schizophrenia; Schizophrenic Disorders; Symptoms; Syndrome; Systems Analyses; Systems Analysis; Testing; Therapeutic; Therapeutic Intervention; Time; Toxic Environmental Agents; Toxic Environmental Substances; Trauma, Nervous System; Undernutrition; VIIIth Cranial Nerve; Vestibulocochlear Nerve; Viral Diseases; Virus Diseases; Work; Zeugmatography; attention deficit hyperactive disorder; auditory nerve; base; chemotherapeutic agent; children; clinical relevance; clinically relevant; dementia praecox; design; designing; dietary deficiency; disease/disorder; early detection; environmental toxicant; experiment; experimental research; experimental study; failure; hearing perception; in vivo; interdisciplinary approach; interpersonal competence; interpersonal competency; intervention design; intervention therapy; interventional strategy; longitudinal analysis; myelination; new approaches; new diagnostics; next generation diagnostics; novel approaches; novel diagnostics; novel strategies; novel strategy; offspring; pathophysiology; prevent; preventing; research study; response; schizophrenic; social competence; social competency; social skills; sound perception; therapy design; tool; treatment design; viral infection; virus infection; youngster",Integrated multidisciplinary approach for analyzing diffuse myelination disorders,"The central hypothesis of this application is that impairment of myelination, irrespective of the mechanisms, can be diagnosed and characterized by utilizing auditory brain stem recordings and analysis as a sensitive and non-invasive diagnostic tool. We focus on two myelin disorders: demyelination caused by exposure to chemotherapeutic agents and hypomyelination as a result of being born to a mother who suffered iron deficiency during pregnancy. We propose experiments that will identify the cell populations that are associated with neural conduction deficits in the auditory system, we will determine whether the auditory system can be used as a novel diagnostic too diffuse myelination impairment and will identify rescue strategies that have clinical relevance.",59739,ZRG1,Special Emphasis Panel,A1,1,921000,
7782313,R01,HD,1,,01/15/2010,12/31/2010,PA-07-070,1R01HD059844-01A1,,NICHD:272935;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,AUSTIN,UNITED STATES,MISCELLANEOUS,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"DINGWELL, JONATHAN BATES;",1991232;,1R01HD059844,01/15/2010,12/31/2014,"Accidental Injury; Address; Adopted; Affect; Age; Aged 65 and Over; Amputation; Amputation, Traumatic; Amputees; Apoplexy; Arts; Balance training; Behavior; Biomechanics; Care, Health; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Crowding; Data; Death; Distal; Elderly; Elderly, over 65; Engineering; Engineerings; Environment; Equilibrium; Event; Evidence based treatment; Exhibits; Fall prevention; Feedback; Foundations; Gait; Goals; Gramineae; Grasses; Healthcare; Healthy People 2010; Height; Hip Fractures; Human; Human, General; Impairment; Injury; Intervention; Intervention Strategies; Knowledge; Laboratories; Lateral; Lead; Leg; Life; Lower Extremity; Lower Limb; Man (Taxonomy); Man, Modern; Measures; Mechanics; Membrum inferius; Modeling; Monitoring, Patient; Motor; Movement; Muscle; Muscle Tissue; Patient Monitoring; Patient Participation; Patients; Pb element; Performance; Physical Health Services / Rehabilitation; Physical activity; Poaceae; Population; Populations at Risk; Preventive Intervention; Prosthesis; Prosthetic device; Prosthetics; Protocol; Protocols documentation; Public Health; Randomized; Recovery; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Research Resources; Resources; Risk; Sensory; Sight; Speed; Speed (motion); Stroke; Surface; Testing; Therapeutic Intervention; Time; Training; Training Programs; Translating; Translatings; Trauma, Brain; Traumatic Amputation; Traumatic Brain Injury; Traumatic encephalopathy; Unintentional Injury; Vascular Accident, Brain; Vision; Visual; Walking; Weight; Work; active control; advanced age; balance; balance function; base; body movement; brain attack; cerebral vascular accident; clinical practice; compare effectiveness; conventional therapy; cost; design; designing; elderly patient; elders; experience; falls; fear of falling; geriatric; heavy metal Pb; heavy metal lead; improved; injured; injury prevention; intervention design; intervention therapy; interventional strategy; kinematics; language translation; late life; later life; neuromuscular; novel; older adult; older patient; older person; patient population; preventional intervention strategy; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; rehabilitative; response; senior citizen; somatosensory; standard care; stroke; therapy design; traumatic brain damage; treatment design; treatment strategy; treatment trial; virtual; virtual reality; visual feedback",Improving Dynamic Walking Stability in Traumatic Amputees," PROJECT NARRATIVE: Falls and the injuries that result from falls are a significant health care problem for the thousands of patients who undergo lower limb amputation every year, as well as for millions of elderly and patients with other locomotor impairments. Determining how these patients use their available sensory and motor resources to regulate stability during walking and developing effective evidence based treatment strategies to improve their walking stability will significantly extend and improve the lives of these patients. The proposed work will apply novel state-of-the-art experimental and analytical approaches to directly address these critical issues.",59844,MRS,Musculoskeletal Rehabilitation Sciences Study Section,A1,1,272935,
7782223,R01,HD,1,,02/01/2010,01/31/2011,PA-08-043,1R01HD059946-01A1,,NICHD:532361;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PORTLAND,UNITED STATES,OBSTETRICS & GYNECOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"MITALIPOV, SHOUKHRAT M;",8048189;,1R01HD059946,02/01/2010,01/31/2015,"Autologous; Blastocyst; Blastocyst structure; Blastosphere; CAM 120/80; CDX-3 Gene; CDX2; CDX2 gene; CDX3 Gene; Cadherin-1; Caudal-Type Homeo Box Transcription Factor 2 Gene; Caudal-Type Homeo Box Transcription Factor 3 Gene; Caudal-Type Homeobox Protein 2 Gene; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Cells; Degenerative Disorder; Derivation; Derivation procedure; Development; E-Cadherin; Embryo; Embryo, Preimplantation; Embryoblast; Embryonic; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Expression Profiling; Expression Signature; Homeobox Protein CDX-2 Gene; Inner Cell Mass; Insulin-Regulating Transcription Factor CDX3 Gene; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Modeling; Molecular Fingerprinting; Molecular Profiling; Monkeys; Mother Cells; Murine; Mus; Nucleus; Oocytes; Outcome; Ovocytes; Patients; Pluripotent Stem Cells; Production; Progenitor Cells; RNA, Small Interfering; Role; Small Interfering RNA; Somatic Cell; Stem cells; Testing; Therapeutic; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uvomorulin; blastocyst; blastula; cultured cell line; degenerative condition; degenerative disease; experiment; experimental research; experimental study; improved; insight; molecuar profile; molecular signature; mouse model; non-human primate; nonhuman primate; nuclear transfer; nuclear transplantation; pre-clinical; preclinical; prevent; preventing; public health relevance; research study; siRNA; social role; somatic cell nuclear transfer; transcription factor",Altered Nuclear Transfer," NARRATIVE In this application we will study the potential of autologous (patient-matched) stem cells derived by somatic cell nuclear transfer in the nonhuman primate model while avoiding the destruction of viable embryos. The outcomes of these experiments, in turn, will allow the production of useful preclinical monkey models for testing therapeutic applications involving autologous stem cells for the treatment of wide range of degenerative diseases.",59946,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",A1,1,532361,
7785865,R01,HD,1,,02/01/2010,01/31/2011,PAR-07-184,1R01HD060576-01A1,,NICHD:527087;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,WORCESTER,UNITED STATES,NEUROLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"ESTEVES, MIGUEL S (contact);MARTIN, DOUGLAS R;",7622764;7941304 (contact);,1R01HD060576,02/01/2010,01/31/2014,"2 year old; 21+ years old; AAV vector; Acids; Adolescent; Adolescent Youth; Adult; Age of Onset; Age-Months; Aged 65 and Over; Animal Model; Animal Models and Related Studies; Animals; Assay; Behavioral; Bioassay; Biochemical; Biologic Assays; Biological Assay; Brain; Caffey pseudo-Hurler syndrome; Caffey syndrome; Capsid; Cats; Cells; Central Nervous System; Cerebellar Nuclei; Cerebrospinal Fluid; Childhood; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clinical assessments; Complementary DNA; Complex; DNA Shuffling; DNA, Complementary; Development; Disease; Disease Progression; Disorder; Domestic Cats; Dose; Dysfunction; Effectiveness; Elderly; Elderly, over 65; Encephalon; Encephalons; Ensure; Enzymes; Evolution, Molecular; Family Felidae; Felidae; Felids; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Frequencies (time pattern); Frequency; Functional disorder; Future; G(A(2)) Ganglioside; G(M1) Ganglioside; G(M1) Gangliosidosis; GA(2) Ganglioside; Galactosidase; Ganglioside GM1; Gangliosidosis GM1; Gene Delivery; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generations; Genes; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Goals; Health; Human; Human, Adult; Human, General; Hurler variant; Hurler-like syndrome; Infant; Infusion; Infusion procedures; Intervention, Genetic; Investigators; Knockout Mice; L-Tyrosine; Landing syndrome; Lateral Ventricle of Brain; Lateral Ventricles; Lateral ventricle structure; Libraries; Live Birth; Longitudinal Studies; Lung; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; Lysosomes; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Cats; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Method LOINC Axis 6; Methodology; Mice; Mice, Knock-out; Mice, Knockout; Modality; Modeling; Modern Medicine; Molecular Biology, Gene Therapy; Molecular Breeding; Molecular Evolution; Monosialosyl Tetraglycosyl Ceramide; Murine; Mus; Mutation; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurochemistry; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neuron Degeneration; Neurons; Neurosciences; Norman-Landing syndrome; Nuclear Magnetic Resonance Imaging; Null Mouse; Organ; Outcome; Patients; Peripheral; Phase; Physiopathology; Process; Research Personnel; Researchers; Respiratory System, Lung; Science of neurochemistry; Serotyping; Severity of illness; Shufflings, DNA; Single-Gene Defect; Spinal Cord; Staging; Surface; TYR; Tay-Sachs disease with visceral involvement; Testing; Thalamic structure; Thalamus; Therapeutic; Therapeutic Studies; Therapy Research; Therapy, DNA; Time; Treatment Efficacy; Tropism; Tyrosine; Tyrosine, L-isomer; Validation; Zeugmatography; adeno-associated viral vector; adeno-associated virus vector; adult human (21+); advanced age; base; beta galactosidase deficiency; beta-galactosidase-1 (GLB1) deficiency; beta-galactosidase-1 deficiency; brain size; cDNA; cerebral GM1 gangliosidosis; clinical investigation; coat (nonenveloped virus); design; designing; disease severity; disease/disorder; effective therapy; efficacy testing; elders; experiment; experimental research; experimental study; familial neurovisceral lipidosis; feline; gagliosidosis GM1, type I; gene therapy; generalized gangliosidosis GM1, type I; generalized infantile gangliosidosis; generalized infantile gangliosidosis with bony involvement; genetic therapy; genome mutation; geriatric; in vivo; inborn lysosomal enzyme disorder; infancy; infantile; juvenile; juvenile human; late life; later life; lateral ventricle; long-term study; meetings; minimally invasive; model organism; mouse model; mutant; nervous system disorder; neural degeneration; neurochemistry; neurodegeneration; neurological disease; neuronal; neuronal Gm(1) gangliosidosis; neuronal degeneration; neurovisceral lipidosis; new approaches; novel approaches; novel strategies; novel strategy; older adult; older person; para-Tyrosine; pathophysiology; pediatric; pseudo-Hurler disease; pulmonary; research study; senior citizen; spinal fluid; thalamic; therapeutic effectiveness; therapeutic efficacy; therapeutically effective; transduction efficiency; transfer of a gene; treatment strategy; two year old; vector",Gene Therapy for Neurodegenerative Lysosomal Storage Diseases," Project Narrative The AAV vector-based approaches investigated in this project for CNS therapy in GM1-gangliosidosis are likely to be applicable to many, if not all neurodegenerative lysosomal storage diseases. The experiments proposed here are essential to determine the scalability and therapeutic efficacy of each approach applied to a much larger and complex brain such as that in GM1-gangliosidosis cats. Moreover the AAV vectors encoding the human lysosomal ¨-galactosidase enzyme developed and tested here for their therapeutic efficacy in GM1 mice and cats may ultimately progress into human clinical trials for this devastating disease for which there is no treatment. Finally, we are proposing to develop a new generation of AAV vectors capable of targeting the brain through the vasculature. This new generation of AAV vectors may provide the means to develop highly effective gene therapy approaches to treat many childhood, adult, and geriatric neurological diseases currently beyond the reach of modern medicine.",60576,ZHD1,Special Emphasis Panel,A1,1,527087,
7784879,R01,HD,1,,02/01/2010,01/31/2011,PA-07-070,1R01HD060628-01A2,,NICHD:578007;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,IRVINE,UNITED STATES,PSYCHIATRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"WADHWA, PATHIK D;",1967470;,1R01HD060628,02/01/2010,01/31/2015,"0-11 years old; 16-Hydroxyestradiol; 16-alpha-Hydroxy-Estradiol; 21+ years old; ACOG; ACTH-Releasing Factor; Accounting; Address; Adult; Adverse Experience; Adverse event; Aeroseb-HC; Affect; Age; Ambulatory Monitoring; American College of Obstetricians and Gynecologists; Animals; Area; Articulation; Assay; Behavior; Behavioral; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biology; Birth; Birth Weight; BlackBerry Device; Blood Sample; Blood Vessels; Blood specimen; Blueberry Device; CRF-41; CRH; Causality; Cetacort; Characteristics; Chemotherapy-Hormones/Steroids; Child; Child Youth; Children (0-21); Chronotropism, Cardiac; Chronotropisms, Cardiac; Cities; Clinical; Clinical Management; Clinical Trial Overviews; Collection; Complex; Cort-Dome; Cortef; Cortenema; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Cortisol; Cortispray; Cortril; Data; Data Pooling; Data Poolings; Data Set; Dataset; Depressed mood; Dermacort; Development; Diaries; Diaries (PT); Diaries [Publication Type]; Diet; Discipline of obstetrics; Drug usage; Drugs, Illicit; Eating; Eldecort; Electronics; Empirical Research; Endocrine; Endocrine Gland Secretion; Endocrine Physiology; Ensure; Environmental Factor; Environmental Risk Factor; Epidemiology; Equation; Estra-1,3,5(10)-triene-3,16,17-triol, (16alpha,17beta)-; Estriol; Ethnic Origin; Ethnicity; Ethnicity aspects; Etiology; Evaluation; Event; Exclusion Criteria; Exhibits; Exposure to; FLR; Failure (biologic function); Fetal Age; Fetal Growth; Fetal Maturity, Chronologic; Food Intake; Future; Genetic; Gestation; Gestational Age; Growth, Fetal; Gynecologist; Hand functions; Head and Neck, Saliva; Health; Health behavior; Heart Rate; Home; Home environment; Hormonal; Hormones; Hostility; Hour; Human; Human, Adult; Human, Child; Human, General; Hydrocortisone; Hydrocortone; Hytone; INFLM; Illicit Drugs; Immune response; Incidence; Individual; Individual Differences; Infant, Small for Gestational Age; Infection; Inflammation; Intervention; Intervention Strategies; Joints; Knowledge; Laboratories; Length; Lesion; Life; Linear Models; Link; Literature; Low Birth Weight Infant; Man (Taxonomy); Man, Modern; Maternal and Child Health; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medical Records; Medicine; Memory; Meta-Analyses; Meta-Analysis; Method LOINC Axis 6; Methodology; Methods; Modeling; Monitor; Monitoring, Ambulatory; Moods; Mothers; NIH; National Academy of Sciences; National Academy of Sciences (U.S.); National Children's Study; National Institutes of Health; National Institutes of Health (U.S.); Natural Disasters; Nature; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nutracort; Obstetrics; Outcome; Outpatient Monitoring; PDA Computer; Palm Pilot; Palm-top; Palm-top computer; Palmtop; Palmtop computer; Parturition; Pathway interactions; Patient Self-Report; Perinatology; Personal Digital Assistant; Personal Digital Assistant Computer; Personality; Persons; Physical activity; Pilot Projects; Play; Pocket PCs; Pocket Personal Computer; Population; Population Study; Predisposition; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Preterm Birth; Preventive; Probability; Procedures; Process; Proctocort; Protocol; Protocols documentation; Psychological Stress; Psychosocial Factor; Psychosocial Stress; Public Health; Race; Racial Group; Recovery; Recruitment Activity; Regression Analyses; Regression Analysis; Regression Diagnostics; Reporting; Research; Research Design; Research Resources; Resources; Respiration; Respiratory physiology; Respondent; Risk; Risk Assessment; Risk Factors; Role; SUBGP; Saliva; Sampling; Science of Medicine; Secondary Prevention; Self-Report; Sensitivity and Specificity; Side; Sleep; Small for Gestational Age Infant; Smoking; Social Interaction; Social support; Specificity; Staging; Statistical Regression; Stocks, Racial; Stress; Stress, Psychological; Study Type; Subgroup; Susceptibility; System; System, LOINC Axis 4; Systems Biology; Terrorism; Testing; Therapeutic Hormone; Therapeutic Hydrocortisone; Time; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; United States; United States National Academy of Sciences; United States National Institutes of Health; Urinary System, Urine; Urine; Using hands; VLBW (human); Variant; Variation; Woman; Work; abstracting; adult human (21+); base; biobehavior; biobehavioral; biopsychosocial; children; clinical research site; clinical site; corticotropin releasing hormone; critical period; depressed; design; designing; diaries; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; environmental risk; experience; failure; fetal; fetal stress; heart rate variability; high risk; host response; immunoresponse; indexing; innovate; innovation; innovative; innovative technologies; insight; instrument; interventional strategy; intrauterine growth; knowledge translation; language translation; low birth weight infant human; low birthweight; lung function; maternal stress; modifiable risk; neglect; optimism; parity; pathway; pilot study; postiive attitude; pregnant; premature childbirth; premature delivery; prenatal; prenatal stress; preterm delivery; prevent; preventing; prospective; psychobiologic; psychobiological; psychologic; psychological; psychosocial; psychosocial variables; public health medicine (field); public health relevance; recruit; respiratory; respiratory function; respiratory mechanism; response; sadness; self esteem; small for gestational age; social; social role; social support network; stressed mothers; stressor; study design; translation research enterprise; unborn; unborn child; vascular; youngster",EMA Assessment of Biobehavioral Processes in Human Pregnancy," PROJECT NARRATIVE  This proposal addresses what is arguably the most important public health issue in maternal-child health in our nation - adverse pregnancy and birth outcomes related to shortened gestation/preterm birth and reduced fetal growth/low birth weight. Several lines of animal and human evidence converge to convincingly suggest that maternal psychosocial stress-related processes in pregnancy represent an important and potentially modifiable risk factor for adverse birth outcomes and subsequent child and adult health outcomes. However, despite many years of empirical research and findings, key questions still remain to be answered about the nature, mechanism and timing of effects of prenatal stress. We argue that the critical first step towards translating prenatal stress findings from the population to the individual level is to develop ways to identify which subgroup(s) of pregnant women (under what circumstances/ context, and at which time/stage in gestation) are particularly susceptible to the detrimental effects of prenatal stress. We propose that newer, innovative technologies and methods based on real-time, ambulatory, repeated sampling of psychological, behavioral and biological states (i.e., ecological momentary assessment (EMA)) can be adapted successfully to achieve this objective. The scientific significance of this research is that it will clarify psychobiological mechanisms that are likely determinants of individual vulnerability for stress-related adverse birth outcomes. The public health impact is that it will increase the sensitivity and specificity of biopsychosocial risk assessment and provide an empirical basis for the development and evaluation of comprehensive intervention strategies to prevent or manage stress in pregnancy and reduce its adverse health consequences in the mother and her unborn child. The objectives, approach, and outcomes of our proposed research are consistent with the emphasis placed by the NIH on clinical translational research and the aspiration in Systems Biology to progress towards the new P4 medicine (predictive, preventive, personalized, participatory) of the future.",60628,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",A2,1,578007,
7786408,R01,HD,1,,01/15/2010,12/31/2010,PA-07-070,1R01HD060680-01A1,,NICHD:572197;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BOSTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"HATCH, ELIZABETH E;",1944220;,1R01HD060680,01/15/2010,12/31/2014,"1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Active Follow-up; Affect; Age; Alcohol Drinking; Alcohol consumption; Alcohols; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Applications Grants; Asthma; Automobile Driving; BMI percentile; BMI z-score; Behavior; Behavioral; Bicycling; Birth; Body mass index; Bronchial Asthma; Caffeine; Cannot achieve a pregnancy; Chemical Class, Alcohol; Clinical; Cohort Studies; Commuting; Conceptions; Concurrent Studies; Consumption; Contraception; Contraceptive methods; Couples; Dairy Products; Data; Data Collection; Denmark; Depression; Diet; Dietary Factors; Difficulty conceiving; Disease; Disorder; Drivings, Automobile; Drugs; Economic Burden; Education; Educational aspects; Emotional Depression; Enrollment; Enteramine; Epidemiologic Methods; Epidemiologic Research; Epidemiologic Studies; Epidemiological Methods; Epidemiological Studies; Epidemiological Techniques; Epidemiology Research; Epidemiology, Methods; Epidemiology, Personal Medical History; Epidemiology, Reproductive History; Esophageal Reflux; EtOH drinking; Evaluation; Fats; Fatty Acids; Fatty acid glycerol esters; Fe element; Fecundability; Fecundity; Female; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Fertility; Fertility Control; Folate; Folic Acid; Food; Food Supplements; Frequencies (time pattern); Frequency; Funding; GERD; Gastro-oesophageal Reflux; Gastroesophageal Reflux; Gastroesophageal reflux disease; Gestation; Glucocorticoids; Goals; Grant Proposals; Grants, Applications; Headache, Migraine; Health, Reproductive; Heme; Heme b; Hippophaine; Infertility; Inhibition of Fertilization; Intake; Intention; Internet; Investigators; Iron; Jobs; Length; Life; Life Style; Lifestyle; Link; Mails; Maintenance; Maintenances; Medical History; Medication; Mental Depression; Methods; Migraine; Miscarriage; N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; Occupational Exposure; Occupations; Outcome; Participant; Parturition; Patient Self-Report; Personal Medical History; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical activity; Pilot Projects; Population; Population Study; Pregnancy; Prevalence; Professional Postions; Prospective Studies; Protoheme; Protoheme IX; Pteroylglutamic Acid; Public Health; Questionnaires; Quetelet index; Recruitment Activity; Registries; Reporting; Reproductive Factors; Reproductive Health; Reproductive History; Reproductive Issues; Research; Research Design; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Factors; SSRI; Saturated Fatty Acids; Selection Bias; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Self-Report; Serotonin; Services; Smoking; Source; Spontaneous abortion; Stress; Study Type; Subfecundity; Symptoms of depression; Telephone Interviews; Therapeutic Glucocorticoid; Time; Time Study; Treatment Effectiveness; Vitamin M; WWW; Woman; Work; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; cohort; cost; cost effective; depressive; depressive symptoms; design; designing; disease/disorder; driving; drug/agent; enroll; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; expectation; ferroheme; follow-up; impaired fecundity; infertile; inhibitor; inhibitor/antagonist; interest; male; modifiable risk; obesity in children; parity; pilot study; population based; pregnant; prospective; public health medicine (field); public health relevance; recruit; reproductive; reproductive epidemiology; sedentary; serotonin reuptake inhibitor; study design; success; unable to bear children; uptake; vitamin Bc; volunteer; web; world wide web",An internet based prospective study of time to pregnancy," Nearly 15% of all couples have difficulty becoming pregnant and approximately 20% of all pregnancies end in miscarriage. Despite their frequent occurrence, few factors have been firmly linked to an increased risk of infertility and miscarriage. Identifying modifiable risk factors for infertility and miscarriage is an important public health goal, especially because the effectiveness of treatments for these conditions is relatively poor.",60680,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",A1,1,572197,
7791090,R01,HD,1,,01/15/2010,12/31/2010,PA-07-070,1R01HD060711-01A2,,NICHD:334169;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CHICAGO,UNITED STATES,SOCIAL SCIENCES,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"GORDON, RACHEL A.;",9479526;,1R01HD060711,01/15/2010,12/31/2012,"0-11 years old; Achievement; Achievement Attainment; Address; Affect; Area; Attention; Behavior; Behavioral; Birth; Caring; Child; Child Care; Child Development; Child Welfare; Child Youth; Child health care; Children (0-21); Cities; Cognition; Cognitive; Communities; Data Set; Dataset; Day Care; Development; Dimensions; Disease; Disorder; Emotional; Evaluation Research; Family; Future; Head Start; Head Start Program; Health; Health behavior; Health, Child; Home; Home environment; Hospitalization, Partial; Hour; Human, Child; Infant and Child Development; Infection Control; Influentials; Injury; Intervention; Intervention Strategies; Intervention Studies; Language; Language Development; Learning; Link; Literature; Locomotor Activity; Longitudinal Studies; Measures; Methods; Modeling; Motor; Motor Activity; NICHD; National Institute of Child Health and Human Development; Outcome; Parturition; Policies; Policy Research; Preparedness; Problem behavior; Program, Head Start; Property; Property, LOINC Axis 2; Proxy; Psychometric; Psychometrics; Puericulture; QOC; Quality of Care; Readiness; Regulation; Reporting; Research; Research, Evaluation; Schools; Social Sciences; Specificity; Survey Instrument; Surveys; Time; Treatment Day Care; Validity and Reliability; Youth; Youth 10-21; acquiring language skills; adolescent welfare; base; behavioral health; behavioral problem; children; cohort; community based care; disease/disorder; early childhood; interpersonal competence; interpersonal competency; interventional strategy; language acquisition; language learning; long-term study; neglect; public health relevance; safety practice; skills; social competence; social competency; social science research; social skills; theories; youngster","Child Health, Cognition, and Behavior: Domain-Specific Estimates of the Effects o"," Significance of the Project The purpose of our proposal is to investigate how domain-specific quality of child care affects child health and development. This research will fill important gaps in the social science literature concerned with the relationship between child care quality and child development. Currently there is insufficient evidence on domain-specificity: associations between specific aspects of care most relevant to particular domains of development and outcomes in the same domain. The absence of research based on a tight link between dimensions of child care quality and specific developmental outcomes has been prominent in criticism of existing research. It also may explain some notable findings of past research such as the higher cognitive achievement of children in center-based versus home-based care and greater behavior problems for children who spend long hours in large-group settings. Here we begin to remedy this limitation of past research by focusing on several specific research questions within the literature on each domain. We also broaden the range of outcomes to study, most notably aspects of school readiness and health. In short, we seek to provide a more complete picture of the relationship between child care quality and developmental outcomes that can be used to inform both policy and practice, and to stimulate further research.  ",60711,SSPS,Social Sciences and Population Studies Study Section,A2,1,334169,
7780961,R01,HD,1,,02/01/2010,01/31/2011,PA-07-070,1R01HD060723-01A1,,NICHD:298687;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,AURORA,UNITED STATES,OBSTETRICS & GYNECOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WINN, VIRGINIA ;",1931550;,1R01HD060723,02/01/2010,01/31/2015,"21+ years old; 72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; ACTH-Releasing Factor; ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Adult; Affect; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Apoplexy; B blood cells; B-Cells; B-Lymphocytes; Back; Basal Plate; Biological; Biology; Blood Pressure, High; Blood Serum; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CDF; CRF-41; CRH; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cause of Death; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Complex; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Cytotrophoblast; Data; Death; Diabetes Mellitus; Diagnostic; Disease; Disorder; Dorsum; Dysfunction; Dysfunction, Liver; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Embryonic Tissue, Placenta; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; FLR; FLT1; FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Failure (biologic function); Flt-1; Functional disorder; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Gene Expression; Gene Expression Profile; Generalized Growth; Genes; Genital System, Female, Uterus; Gestation; Gestosis, EPH; Goals; Growth; HEK3; HILDA; Health; Health Care Costs; Health Costs; Healthcare Costs; Heart Diseases; Hops; HuB219; Human; Human, Adult; Human, General; Humulus; Hypertension; ITIM; Immunoreceptor Tyrosine-Based Inhibitory Motif; In Vitro; Infant; Intracellular Communication and Signaling; Invaded; Investigators; Kinases; LEP-R; LEPR; LEPR Protein; LIF; LIF gene; Laboratories; Lead; Leptin; Ligands; Liver Dysfunction; MMP-2; MMP-9; MMP-9 Protein; MMP2; MMP9; Macrophage Gelatinase; Mammals, Primates; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Measures; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mothers; Myocardial Infarct; Myocardial Infarction; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; PEX; PTK; Pathogenesis; Pathway interactions; Pb element; Phospho-Specific Antibodies; Phosphopeptide-Specific Antibodies; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Phosphotransferases; Physiopathology; Placenta; Placenta-Tissue, Cells; Placental Development; Placentation; Placentoma, Normal; Placentome; Play; Poisons; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnant Women; Premature Birth; Preterm Birth; Primates; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proteinuria-Edema-Hypertension Gestosis; Proto-Oncogene Protein flt; Receptor Protein; Receptor Tyrosine Kinase,Class V; Research; Research Personnel; Researchers; Role; Seizures; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Staging; Stillbirth; Stress; Stroke; Structure of cytotrophoblast; Swelling; Tail; Testing; Tissue Growth; Tissues; Toxemias, Pregnancy; Toxic Chemical; Toxic Substance; Transphosphorylases; Type V Collagenase; Tyrosine Kinase; Tyrosine Protein Kinase FRT; Tyrosine Protein Kinase Receptor FLT; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Urinary System, Urine; Urine; Uterus; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; VEGFR-1; VEGFR1; VEGFs; Vascular Accident, Brain; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vegf; Villous; Woman; Work; adult human (21+); biological signal transduction; brain attack; cardiac infarct; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; corticotropin releasing hormone; cultured cell line; cytotrophoblast; diabetes; disease risk; disease/disorder; disorder risk; experience; failure; fetus cell; fms-Like Tyrosine Kinase; gene expression signature; gene product; heart attack; heart disorder; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; hydroxyaryl protein kinase; hyperpiesia; hyperpiesis; hypertensive disease; improved; inhibitor; inhibitor/antagonist; insight; interstitial; knock-down; leptin receptor; leptin-binding protein; mutant; neonatal morbidity; novel; ob/ob mouse; ontogeny; overexpression; pathophysiology; pathway; poison; pregnancy toxemia/hypertension; premature childbirth; premature delivery; preterm delivery; public health relevance; receptor; response; sialic acid binding Ig-like lectin; siglec; social role; stroke; toxic compound; transcriptome; treatment strategy; trophoblast; tyrosyl protein kinase; vector control; womb","Functional significance of Siglec-6, a novel leptin receptor, in human placental"," Preeclampsia is a disorder that affects four to eight percent of pregnancies and is a leading cause of death among pregnant women worldwide. Women with preeclampsia (PE) experience swelling and high blood pressure in the second half of pregnancy that can progress to stroke, heart attack, liver dysfunction, or seizure. For the baby, PE can cause growth failure or stillbirth. Those babies that do survive have an increased risk of disorders as adults including diabetes and heart disease. In part, PE develops because the placenta does not form properly. However, why the placenta does not form correctly is not completely understood. The cure for PE is delivery of the placenta. The need for delivery is responsible for 15% of all preterm birth in the U.S. The general goal of our research is to understand normal placental development and the role of abnormal placental development in the pathogenesis of preeclampsia. The placenta is created by cells from the fetus, which invade into the mother's uterus. If these fetal cells, cytotrophoblasts (CTBs), do not invade sufficiently, pregnancy problems such as PE can occur. Inadequate invasion of CTBs results in a poorly perfused placenta. The stressed placenta gives off substances that are ""toxic"" to the mother causing the swelling, high blood pressure, leaking protein in the urine and other complications of PE. Previous work in our laboratory has shown that the basal plate region of placentas, were the CTBs invade, from women with PE express more leptin and Siglec-6 (sialic acid binding Ig like lectin 6), a leptin receptor, compared to those from normal pregnancies, while the classic leptin receptor levels (ObR) are not different. This proposal focuses on these three specific molecules- leptin, and its known receptors (ObR and Siglec-6)- to determine how they may go awry in PE. In this proposal we will test the hypothesis that Siglec-6 overexpression inhibits leptin promotion of CTB differentiation and invasion by altering ObR signaling by answering the following questions: Aim 1. Does Siglec-6 inhibit leptin promotion of human CTB invasion? Aim 2. Are the ObR signaling pathways critical for human CTB invasion modified by Siglec-6 expression? Aim 3. What downstream targets of ObR signaling are altered by Siglec-6 expression during CTB differentiation and invasion? Discovering how the PE-associated molecules leptin and Siglec-6 regulate CTB invasion will determine their potential role in early PE pathogenesis. Ultimately, understanding the complex pathways that regulate trophoblast invasion will provide the insights needed to develop novel preventative, diagnostic and/or treatment strategies geared at the cause rather than the consequences of this serious pregnancy disease, in the hop of improving the health of the 8 million woman-infant pairs annually afflicted by PE.",60723,PN,Pregnancy and Neonatology Study Section,A1,1,298687,
7793344,R01,HD,1,,01/11/2010,12/31/2010,PA-07-070,1R01HD061457-01A1,,NICHD:202313;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LOS ANGELES,UNITED STATES,MISCELLANEOUS,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"KAISER, ELSI M;",7752578;,1R01HD061457,01/11/2010,12/31/2012,"0-11 years old; Accounting; Alogia; Alogias; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Anepia; Anepias; Aphasia; Causality; Child; Child Youth; Children (0-21); Cognition; Cognitive; Communication; Comprehension; Cues; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependency; Dependency (Psychology); Environment; Etiology; Event; Eye; Eyeball; Fertility/Fertilization; Fertilization; Goals; Human; Human, Child; Human, General; Individual; Information Management; Knowledge; Language; Learning; Light; Linguistic; Linguistics; Logagnosia; Logamnesia; Logamnesias; Logasthenia; Logasthenias; Man (Taxonomy); Man, Modern; Memory; Methods; Mind; Nature; Perception; Photoradiation; Play; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Research; Resolution; Role; Semantic; Semantics; Sight; Specificity; Structure; System; System, LOINC Axis 4; Testing; Vision; Visual; Work; abstracting; base; children; dementia of the Alzheimer type; disease causation; disease etiology; disease/disorder etiology; disorder etiology; emotional dependency; experiment; experimental research; experimental study; insight; language processing; mental representation; novel; prevent; preventing; primary degenerative dementia; public health relevance; research study; senile dementia of the Alzheimer type; social role; tool; visual stimulus; youngster",The Role of Cognitive Coherence in Reference Resolution," Research on the mental representations involved in the interpretation of pronouns (she, it, they) - in particular the extent of their linguistic and cognitive generality - can potentially contribute to our understanding of the discourse-level challenges faced by second-language learners, children, and linguistically- and/or memory- impaired individuals (e.g., individuals with aphasia or Alzheimer's disease). In addition, the proposed research has the potential to bring together insights from linguistic and visuo-spatial research, thereby furthering our understanding of how humans recognize and represent semantic relations between events - an aspect of cognition that is crucial for our ability to learn and reason about our environment.",61457,LCOM,Language and Communication Study Section,A1,1,202313,
7762906,R01,HG,1,,02/01/2010,01/31/2011,PA-07-070,1R01HG005216-01,,NHGRI:281522;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,MINNEAPOLIS,UNITED STATES,ENGINEERING (ALL TYPES),05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"DORFMAN, KEVIN D;",7255830;,1R01HG005216,02/01/2010,01/31/2013,"Accounting; Area; Biological Models; Biology; Biomedical Research; Caliber; DNA; DNA Fingerprinting; DNA Profiling; DNA Profilings; DNA Typing; Data; Deoxyribonucleic Acid; Device Designs; Devices; Diameter; Electrophoresis; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Pulsed-Field Gradient; Engineering; Engineerings; Ensure; Fingerprintings, DNA; Fractionation, Electrophoretic; Fractionation, Pulse Field; Gel; Generations; Genome; Genomics; Goals; Hour; Laboratories; Laws; Lead; Literature; Maps; Medicine; Methods; Microfluidic; Microfluidics; Microscopy, Video; Model System; Models, Biologic; Organism; PFGE; PROV; Pb element; Performance; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Province; Radial; Reading; Relaxation; Research; Resolution; Sampling; Science of Medicine; Screening procedure; Shotgun Sequencing; Staging; System; System, LOINC Axis 4; Technology; Time; Translating; Translatings; Translations; Video Microscopy; Videomicrography; Videomicroscopy; Work; base; cost; design; designing; experiment; experimental research; experimental study; genome sequencing; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; insight; language translation; living system; migration; models and simulation; nano fluidic; nano meter scale; nano meter sized; nano scale; nanofluidic; nanometer scale; nanometer sized; nanoscale; pathogen; physical mapping; programs; public health relevance; research study; restriction enzyme; screening; screenings; simulation; single molecule; tool; trend",Rational Engineering of Nanopost Arrays for DNA Electrophoresis," The proposed work will lead to improved nanoscale systems for rapid and high-resolution separations of long DNA. These devices will accelerate a number of key genomics applications, such as DNA fingerprinting of infec- tious organisms and genome assembly.",5216,ISD,Instrumentation and Systems Development Study Section,,1,281522,
7777014,R01,HG,1,,01/28/2010,11/30/2010,PA-07-070,1R01HG005254-01,,NHGRI:232165;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,BLACKSBURG,UNITED STATES,NONE,09,003137015,US,VA,24060,VIRGINIA POLYTECHNIC INST AND ST UNIV,"HOESCHELE, INA ;",6982631;,1R01HG005254,01/28/2010,11/30/2012,"Accounting; Algorithms; Animals; Arthritis; Au element; Cardiovascular Diseases; Chromosome Mapping; Code; Coding System; Complex; Computing, Statistical; DNA Markers; DNA Methylation; Data; Data Set; Dataset; Development; Disease; Disease Association; Disorder; Environment; Expression Profiling; Expression Signature; Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Transcription; Genes; Genes, Regulator; Genetic; Genetic Transcription; Genetic analyses; Genetics, Gene Mapping; Genotype; Goals; Gold; Human; Human, General; InAs; Language; Least Squares; Least-Squares Analyses; Least-Squares Analysis; Linkage Mapping; Man (Taxonomy); Man, Modern; Maps; Markov Chains; Markov Process; Measures; Methods; Modeling; Molecular Fingerprinting; Molecular Profiling; Multivariate Analyses; Multivariate Analysis; Obesity; Osteoporosis; Pathway interactions; Phenotype; Population; Preventive; QTL; Quantitative Trait Loci; RNA Expression; Randomized; Regulator Genes; Regulatory Pathway; Sampling; Simulate; Statistical Computing; Statistical Computings; Structure; System; System, LOINC Axis 4; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; adiposity; arthritic; base; cardiovascular disorder; corpulence; corpulency; corpulentia; disease phenotype; disease/disorder; experiment; experimental research; experimental study; genetic analysis; genetic mapping; genome-wide; human disease; indium arsenide; interest; measurement of metabolism; metabolomics; molecuar profile; molecular signature; mouse model; obese; obese people; obese person; obese population; pathway; public health relevance; randomisation; randomization; randomly assigned; regulatory gene; research study; trait; trans acting element; user-friendly",Highly multivariate quantitative trait loci mapping in systems genetics," Linkage mapping of Quantitative Trait Loci (QTL) in inbred line crosses of animal (mouse) models of human diseases and association mapping of QTL in human populations for genome- wide gene expression traits and disease phenotypes (and other 'omics', e.g. metabolomics, traits) are critical steps in systems genetics approaches to the identification of genes, pathways and regulatory networks underlying complex human diseases, such as cardiovascular disease, obesity, osteoporosis, arthritis and so on. Identifying key targets in regulatory networks underlying diseases is a critical step towards the development of better therapies and preventive measures for these complex diseases.",5254,GCAT,"Genomics, Computational Biology and Technology Study Section",,1,232165,
7776715,R01,HL,1,,02/03/2010,01/31/2011,PA-07-046,1R01HL089495-01A2,,NHLBI:746860;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PISCATAWAY,UNITED STATES,PSYCHIATRY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"LEHRER, PAUL M;",1872336;,1R01HL089495,02/03/2010,01/31/2014,"(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ butyraldehyde; 1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-; 2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol; Acute; Adherence; Adherence (attribute); Adrenal Cortex Hormones; Adverse effects; Affect; Air; Airway Hyper-responsiveness; Albuterol; American Lung Association; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arrhythmia, Sinus; Aspiration, Respiratory; Asthma; Baroreflex; Behavioral; Biofeedback; Biology; Breathing; Bronchial Asthma; Bronchial Constriction; Bronchial-Dilating Agents; Bronchoconstriction; Bronchodilation; Bronchodilator Agents; Bronchodilators; Budesonide; Caring; Cessation of life; Characteristics; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Complement; Complement Proteins; Corticoids; Corticosteroids; Death; Dentistry; Diagnostic Findings; Disease; Disorder; Dose; Drugs; ELIG; Eligibility; Eligibility Determination; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Ensure; Exhalation; Exhaling; Expiration, Respiratory; FEV1; FEV1%VC; Fear; Forced Expiratory Volume 1 Test; Forced Expiratory Volume in 1 Second; Forced Vital Capacity; Fright; Goals; Guidelines; Health; Height; INFLM; Inflammation; Inhalation; Inhaling; Inspiration, Respiratory; Investigators; Investments; Jewish; Jewish, follower of religion; Laboratories; Learning; Life; Measures; Medication; Medicine; Methodology, Research; Methods; Mononitrogen Monoxide; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; National Heart, Lung, and Blood Institute; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Outcome; Outcome Measure; PBO; PEFR; PFT/FEV1; Patients; Peak Expiratory Flow Rate; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic; Physiological; Placebos; Population; Predisposition; Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocol Screening; Protocols documentation; Proventil; Psychological Stress; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; QOL; Quality of life; Randomized; Recruitment Activity; Reflex, Baroreceptor; Regimen; Research; Research Methodology; Research Methods; Research Personnel; Researchers; Resistance; Respiratory physiology; Risk; Role; Running; Safety; Salbutamol; Science of Medicine; Self Management; Severities; Sham Treatment; Signs and Symptoms; Sinus Arrhythmia; Site; Spirometry; Steroid Compound; Steroids; Stress; Stress, Psychological; Susceptibility; Symptoms; Testing; Therapeutic; Therapeutic Corticosteroid; Time; Training; Treatment Side Effects; Tweens; Validation; Ventolin; Vital capacity; Work; airway epithelium infalmmation; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway inflammation; airway smooth muscle; alternative treatment; asthma MDI; asthma controller; asthma inhaler; asthma reliever; base; biofeedback conditioning; clinical investigation; clinical significance; clinically significant; combination therapy; combined modality treatment; combined treatment; constriction; design; designing; disability; disease/disorder; drug/agent; efficacy testing; endothelial cell derived relaxing factor; experience; follower of religion Jewish; heart rate variability; improved; indexing; inspiration; lumen dilator; lung function; meetings; methacholine; multimodality therapy; non-drug; non-drug therapy; non-drug treatment; nondrug therapy; nondrug treatment; novel; open label; pneumography; primary outcome; programs; public health medicine (field); public health relevance; pulmonary function; randomisation; randomization; randomized trial; randomly assigned; recruit; rescue inhaler; resistant; respiratory; respiratory function; respiratory smooth muscle; response; secondary outcome; sham therapy; side effect; social role; therapy adverse effect; treatment adverse effect; treatment center; treatment effect",Heart Rate Variability Biofeedback: Its Role in Asthma Therapeutics," Effective nondrug treatment for asthma, a disease affecting 10% of the population, is important for public health because almost 50% of asthma patients fail to take prescribed steroid medications, substantially increasing disability and expense. Preliminary studies documented that heart rate variability biofeedback allows asthma patients to decrease inhaled steroid medication while decreasing asthma symptoms and exacerbations and improving lung function. This study will verify the preliminary findings using standard and objective research methodology, and will assess whether heart rate variability biofeedback changes two physiological markers considered to be hallmarks of asthma, namely airway irritability and airway inflammation, and will determine the extent to which this treatment can substitute for inhaled steroid treatment, and/or whether it can complement this currently accepted first-line treatment.",89495,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",A2,1,746860,
7783700,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL092144-01A1,,NHLBI:401771;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"COLOMBO, PAOLO C;",6386053;,1R01HL092144,02/01/2010,01/31/2015,"Abscission; Active Oxygen; Acute; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Area; Arm; Blood Plasma; Blood Pressure; Blood Pressure, Venous; Blood Vessels; Cardiac Diseases; Cardiac Disorders; Care, Health; Chronic; Clinical; Compensation; Coupled; Data; Development; Disease; Disorder; Dysfunction; Economic Inflation; Endocrine; Endothelial Cells; Endothelium; Endothelium, Vascular; Equation; Event; Excision; Experimental Models; Experimental Models, Other; Extirpation; Financial compensation; Functional disorder; Future; Gene Expression; Gene Proteins; Genes; Genetic; Genome; HOSP; Health; Healthcare; Heart Diseases; Heart failure; History; Hospitalization; Hospitals; Hour; Human; Human, General; INFLM; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Individual; Inflammation; Inflammatory; Inflation; Kidney Failure; Kidney Insufficiency; Link; Man (Taxonomy); Man, Modern; Measures; Medicine; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Modeling; Models, Experimental; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurohormones; Organ; Oxidative Stress; Oxygen Radicals; Pathway interactions; Patients; Peripheral; Physiopathology; Plasma; Prevention; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Protein Analysis; Protein Gene Products; Proteins; Public Health; RNA, Messenger; Randomized; Reactive Oxygen Species; Recording of previous events; Removal; Renal Failure; Renal Insufficiency; Research; Research Resources; Resolution; Resources; Reticuloendothelial System, Serum, Plasma; Role; Sampling; Science of Medicine; Series; Serum, Plasma; Side; Stimulus; Stretching; Surgical Removal; Symptoms; Techniques; Testing; Therapeutic; Time; Translating; Translatings; Ultrafiltration; United States National Institutes of Health; Up-Regulation; Up-Regulation (Physiology); Upper arm; Upregulation; Vascular Endothelium; Veins; Venous; Venous Pressure; Venous Pressure level; anti-oxidant; base; cardiac failure; design; designing; disease/disorder; gene product; heart disorder; hemodynamics; in vivo; intervention design; language translation; mRNA; microarray technology; minimally invasive; novel; paracrine; pathophysiology; pathway; programs; protein expression; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; resection; response; social role; therapy design; treatment design; vascular",Endothelial Oxidative Stress and Inflammation:Mechanisms and Human Studies," PROJECT NARRATIVE Chronic heart failure (CHF) is a major health problem; a systemic rather than only cardiac disorder characterized by vascular and neurohormonal derangement. Patients with CHF are responsible for consuming a large percentage of the health care resources as they are frequent hospitalized for acute decompensation. The results of this study will help elucidate the vascular and neurohormonal events that sustain clinical compensation and/or promote resolution of decompensation in the unique CHF patient, thus paving the way to more predictive and personalized medicine.",92144,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,A1,1,401771,
7782599,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL092985-01A2,,NHLBI:405991;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ABRAHAM, MARIA ROSELLE;BENGEL, FRANK MICHAEL (contact);",8561449 (contact);8746865;,1R01HL092985,01/15/2010,12/31/2014,"Adhesion Molecule; Area; Biology; Body Tissues; Bone Marrow Cell Transplantation; Bone Marrow Stem Cell; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cell Adhesion Molecules; Cell Survival; Cell Therapy; Cell Transplantation; Cell Transplants; Cell Viability; Cells; Clinical; Clinical Management; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Decision Making; Disease; Disorder; Echocardiogram; Echocardiography; Engraftment; Environment; Extracellular Matrix, Integrins; Future; Goals; Hand; Heart Diseases; Histologic; Histologically; Image; Imaging Procedures; Imaging Techniques; Individual; Integrins; Intermediary Metabolism; Investigation; Left; METBL; Mammals, Rats; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Metabolic Processes; Metabolism; Modeling; Molecular Target; Mother Cells; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardium; Natural regeneration; Nuclear; Outcomes of Therapy; Patient Selection; Perfusion; Play; Progenitor Cells; Protocol; Protocols documentation; Rat; Rattus; Regeneration; Residual; Residual state; Role; Signaling Molecule; Stem cells; Technics, Imaging; Testing; Therapeutic; Therapy, Cell; Time; Tissues; Transplantation; Transplantation, Bone Marrow Cell; Transplants, Cell; Transthoracic Echocardiography; Treatment Efficacy; Up-Regulation; Up-Regulation (Physiology); Upregulation; Wit; Work; base; cardiac infarct; cardiac muscle; cell adhesion protein; cell type; cell-based therapy; clinical investigation; coronary attack; coronary infarct; coronary infarction; design; designing; disease/disorder; function improvement; functional improvement; functional outcomes; heart attack; heart disorder; heart infarct; heart infarction; heart muscle; heart sonography; imaging; improved; injured; innovate; innovation; innovative; insight; molecular imaging; new approaches; novel approaches; novel strategies; novel strategy; public health relevance; regenerate; regenerative; repair; repaired; social role; sound measurement; stem cell therapy; success; therapeutic efficacy; therapeutically effective; therapy outcome; transplant",Imaging of the Myocardial Microenvironment to Facilitate Stem Cell Engraftment," Project Narrative / Relevance  Cardiac stem cell therapy is condsidered to be a very promising approach for repair of damaged myocardium, but the benefit in clinical trials is currently still variable. In this proposal, molecular imaging techniques are introduced which aim at improving cell therapy by providing information about myocardial microenvironmental conditions which are most suitable for stem cell engraftment. Such biologic imaging strategies have the potential to guide individual therapeutic decisions, and are thus highly relevant to optimize the benefit of stem cell therapy in the clinical management of heart disease.",92985,MEDI,Medical Imaging Study Section,A2,1,405991,
7779814,R01,HL,1,,02/01/2010,11/30/2010,PA-07-070,1R01HL092991-01A2,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"SEHAYEK, EPHRAIM ;",6272906;,1R01HL092991,02/01/2010,11/30/2013,"1,2-diacylglycerol; Absorption; Animals; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bio-Informatics; Bioinformatics; Blood Plasma; Body Weight; Body Weight decreased; Caco-2 Cells; Candidate Disease Gene; Candidate Gene; Cell Culture Techniques; Cell Death; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol, Dietary; Chromosome 14; Chromosome Mapping; Chromosomes, Human, Pair 14; Congenic Strain; DAG; Development; Diacylglycerols; Diet; Dietary Cholesterol; Dietary Fats; Dietary Fatty Acid; Diglycerides; Distal; EC 2; Enterocytes; Enzymes; Event; FLR; Failure (biologic function); Fat Body; Fats; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty acid glycerol esters; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic Markers; Genetics, Gene Mapping; Goals; Human; Human, General; Hypercholesteremia; In Vitro; Inbred Strains Mice; Individual; Intermediary Metabolism; Intestinal; Intestines; Knock-out; Knockout; Lead; Linkage Mapping; Lipids; Liver; METBL; Man (Taxonomy); Man, Modern; Maps; Measures; Metabolic Processes; Metabolic syndrome; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice, Inbred Strains; Molecular; Mono-S; MonoS; Obesity; Ortholog; Orthologous Gene; Over weight; Overweight; Pb element; Phytosterols; Plant Sterols; Plasma; Position; Positioning Attribute; Process; Process of absorption; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; Role; Serum, Plasma; Sterols; Testing; Transferase; Weight Loss; Weight Reduction; absorption; adiposity; atheromatosis; atherosclerotic vascular disease; body system, hepatic; body weight loss; bowel; cholesterol absorption; congenic; corpulence; corpulency; corpulentia; diacylglycerol; dietary lipid; diglyceride; failure; fat metabolism; fatty acid metabolism; fatty acid oxidation; gene discovery; genetic mapping; heavy metal Pb; heavy metal lead; hypercholesterolemia; lipid metabolism; microbial; necrocytosis; new therapeutic target; novel; obese; obese people; obese person; obese population; organ system, hepatic; public health relevance; response; social role; uptake; wt-loss",Cholesterol_fat_absorption," The discovery of genes that control the processes of dietary cholesterol and dietary fat absorption from the intestine will increase our understanding of these processes at the molecular level, may lead to the development of genetic markers to identify individuals with increased absorption of dietary cholesterol and fat, and identify new targets for therapy of hypercholesterolemia, overweight and obesity.",92991,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,A2,1,392500,
7783229,R01,HL,1,,01/18/2010,12/31/2010,PA-07-070,1R01HL093017-01A2,,NHLBI:413750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"ELIAS, JACK A;",1866855;,1R01HL093017,01/18/2010,12/31/2013,"38-kDa heparin-binding glycoprotein, human; AKT; APO-1; ATGN; Acute; Address; Akt protein; Allergic inflammation; Animals; Antifungal Agents; Antifungal Drug; Antigens; Antisera; Apoptosis; Apoptosis Pathway; Area; Aspergillus; Asthma; Binding; Binding (Molecular Function); Binding Sites; Biology; Blood Circulation; Blood Serum; Bloodstream; Body Tissues; Breast; Breeding; Bronchial Asthma; CD95; CHI3L1 protein, human; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Protection; Cell Signaling; Cells; Cessation of life; Chitin; Chitin Synthase; Chitin-UDP Acetylglucosaminyltransferase; Chitinase; Chronic; Circulation; Cleaved cell; Combining Site; Crustacea; Cytoprotection; Death; Defect; Disease; Disorder; EC 2.7.2-; ERK3 Kinase; Enzymes; Epithelial; Epithelial Cells; Evaluation; Event; Extracellular Signal-Regulated Kinase, p97; Extracellular Signal-Regulated Kinases; FASTM; Family; Family member; Fungicides, Therapeutic; GeneHomolog; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Health; Homolog; Homologous Gene; Homologue; Human; Human Biology; Human, General; Hydrolase; IFN; IL-13; IL-13 binding protein; IL-13 receptor; IL-13R; IL13; INFLM; IgE; Immune Sera; Immunoglobulin E; In Vitro; Inflammation; Inflammatory; Interferons; Interleukin-13; Intracellular Communication and Signaling; Knowledge; Laboratories; Life Cycle; Life Cycle Stages; Lung; MAP Kinase 6; MAP kinase; MAPK; MAPK6 Mitogen-Activated Protein Kinase; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Mitogen-Activated Protein Kinase 6; Mitogen-Activated Protein Kinases; Modeling; Molecular Interaction; Murine; Mus; Mutation; Names; PKB protein; Parasites; Pathogenesis; Pathway interactions; Patients; Phenotype; Play; Poly(1,4-(N-acetyl-beta-D-glucosaminide)) glycanohydrolase; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition gene; Process; Production; Protein Kinase B; Protein Kinase, Mitogen-Activated 5; Proteins; Proto-Oncogene Proteins c-akt; RAC-PK protein; RNA, Messenger; RNA, Small Interfering; Reaction; Reactive Site; Receptor Signaling; Recombinants; Regulation; Relative; Relative (related person); Research; Respiratory System, Lung; Respiratory physiology; Role; Serum; Severity of illness; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Susceptibility Gene; T-Cells; T-Lymphocyte; TNFRSF6; TNFRSF6 gene; Testing; Thymus-Dependent Lymphocytes; Tissues; Transgenic Organisms; UDP-N-acetyl-D-glucosamine[{..}]chitin 4-beta-N-acetylglucosaminyltransferase; YKL-39 protein, human; acidic mammalian chitinase; anti-fungal; antifungals; antigen challenge; biological signal transduction; c-akt protein; cartilage gp-39, human; cleaved; cytokine; defined contribution; disease severity; disease/disorder; experiment; experimental research; experimental study; extracellular signal-regulated kinase 3; fungus; gene product; genome mutation; human CHI3L1 protein; human cartilage glycoprotein-39; human cartilage gp39; immunogen; in vivo; insight; interleukin-13 receptor; life course; lung function; mRNA; macrophage; man; man's; necrocytosis; null mutation; overexpression; p97(MAPK) Protein; p97MAPK Protein; pathway; polymorphism; predisposing gene; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; prototype; public health relevance; pulmonary; rac protein kinase; related to A and C-protein; research study; respiratory function; response; selective expression; selectively expressed; siRNA; social role; thymus derived lymphocyte; trans-N-Acetylglucosaminosylase; transgenic",BRP-39/YKL-40 in Th2 Inflammation and Asthma," PROJECT NARRATIVE Our studies demonstrated that a protein named BRP-39 plays a critical role in asthma-like inflammation in the mouse and that the human equivalent, YKL-40, is found in exaggerated quantities in the circulation of people with severe asthma. They also demonstrated that BRP-39/YKL-40 likely mediates its biologic effects by controlling the death of inflammatory cells. This proposal will investigate the processes that regulate the production of this molecule and define the receptor, signaling pathways and mechanisms that It uses to regulate cell death.",93017,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",A2,1,413750,
7782625,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL093074-01A2,,NHLBI:485900;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,PHYSIOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SALAMA, GUY ;",1884225;,1R01HL093074,01/15/2010,12/31/2013,"Adrenergic Agents; Adrenergic Drugs; Adrenergics; Affinity; Arrhythmia; Atrial; Auricle of Heart; Binding; Binding (Molecular Function); Cardiac; Cardiac Arrhythmia; Cardiac Atrium; Cardiac Complexes, Premature; Cardiac Diseases; Cardiac Disorders; Cardioversion; Cations; Cell membrane; Cells; Cleaved cell; Closure by Ligation; Coloring Agents; Coronary Vessels; Crown Compounds; Crown Ethers; Cytoplasmic Membrane; Defibrillation, Electric; Diffuse; Dyes; Ectopic beats; Electric Countershock; Electrophysiology; Electrophysiology (science); Electroversion, Cardiac; Electroversions, Cardiac; Epicardium; Equilibrium; Exhibits; Extrasystole; Fiber; Fluorescence; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Fluorescent Probes; Goals; Heart; Heart Arrhythmias; Heart Atrium; Heart Diseases; Heterogeneity; In Vitro; Intervention; Intervention Strategies; Ion Channels, Potassium; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; K channel; Kinetic; Kinetics; Lead; Ligation; Lipid Bilayers; Liquid substance; Maps; Measures; Membrane; Membrane Potentials; Metabolic; Methods; Molecular Interaction; Muscle Cells; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial Ischemia; Myocardium; Myocytes; Neurophysiology / Electrophysiology; Optics; Pathology; Pb element; Physiologic; Physiological; Physiology; Plasma Membrane; Potassium Channel; Premature Beats; Premature Complices, Cardiac; Probes, Fluorescent; Property; Property, LOINC Axis 2; Pump; Recurrence; Recurrent; Regulation; Reperfusion Therapy; Reporting; Rest; Resting Potentials; Role; Tail; Testing; Time; Transmembrane Potentials; Ventricular; adrenergic; aqueous; atrium; balance; balance function; base; cardiac electrical activity; cardiac muscle; cleaved; defibrillation; electric countershock heart resuscitation; extracellular; fluid; fluorescent dye/probe; heart disorder; heart electrical activity; heart ischemia; heart muscle; heavy metal Pb; heavy metal lead; improved; interstitial; interventional strategy; lipid bilayer membrane; liquid; membrane structure; myocardial ischemia/hypoxia; myocardium ischemia; new approaches; new therapeutic target; novel approaches; novel strategies; novel strategy; plasmalemma; premature; prevent; preventing; public health relevance; reperfusion; response; social role; stop flow technique; success; uptake",Effects of K+ Accumulation/Depletion in the Heart," Extracellular K+ accumulation in T-tubules and narrow invaginations of heart muscle has been implicated as a determinant of normal cardiac physiology and pathology. However, [K+] concentrations in narrow regions that are not in diffusional equilibrium with the surrounding aqueous medium have never been measured directly. The project will synthesize new K+ indicator probes, measure [K+] in t-tubules, and interstitial spaces and characterize local [K+] accumulation in normal physiological conditions and various pathologies. The role of K+ accumulation may lead to a new understanding of mechanisms that enhanced the likelihood of arrhythmias, provide novel approaches to reduce defibrillation threshold, reduce the recurrence of VF after defibrillation, improve the success rate of defibrillation past 5 min of fibrillation and may lead to new therapeutic targets for the treatment of ischemic heart disease.",93074,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",A2,1,485900,
7779535,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL093146-01A2,,NHLBI:462849;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,OTHER HEALTH PROFESSIONS,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"FAN, VINCENT S;NGUYEN, HUONG Q (contact);",7744092 (contact);8310106;,1R01HL093146,02/01/2010,01/31/2015,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; 5HT transporter; 5HTT protein; Activities of Daily Living; Activities of everyday life; Adverse effects; Affective Disorders; Alleles; Allelomorphs; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Assay; Au element; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bioassay; Biologic Assays; Biological; Biological Assay; Blood Sample; Blood specimen; Brain; Breath Shortnesses; Breathlessness; COAD; COPD; Cachectin; Cachectin-Tumor Necrosis Factor; Cause of Death; Chronic; Chronic Disease; Chronic Illness; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Chronic lung disease; Chronically Ill; Clinical; Conditioning Therapy; Coughing; Data; Depression; Depressive disorder; Development; Differentiation Factor, B-Cell; Disease; Disease Progression; Disease remission; Disorder; Drug Therapy; Dysfunction; Dyspnea; Dyspneas; Emotional Depression; Encephalon; Encephalons; Enteramine; Equation; Exercise; Exercise, Physical; Functional disorder; Gene variant; Generalized Growth; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genotype; Goals; Gold; Growth; HPGF; Health; Hepatocyte-Stimulating Factor; Hippophaine; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Inflammation; Inflammatory; Inherited Predisposition; Inherited Susceptibility; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intervention; Intervention Strategies; Lead; Life Style Modification; Link; MGI-2; Measures; Mediating; Medical; Mental Depression; Methods and Techniques; Methods, Other; Minisatellite Repeats; Minisatellites; Modeling; Mood Disorders; Mortality; Mortality Vital Statistics; Myeloid Differentiation-Inducing Protein; Nerve Transmitter Substances; Nervous System, Brain; Neurosis, Depressive; Neurotransmitters; Organ System; Outcome; Patients; Pb element; Pharmacotherapy; Physical activity; Physiopathology; Plasmacytoma Growth Factor; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Prevalence; Process; Production; Prospective Studies; Pulmonary Disease, Chronic Obstructive; QOL; Quality of life; RMSN; Recruitment Activity; Relative; Relative (related person); Remission; Reporting; Respiratory physiology; Risk; Role; Serotonin; Severities; Shortness of Breath; Simple Repetitive Sequence; Spirometry; Sputum; Staging; Symptoms of depression; Synapses; Synaptic; TNF-alpha; Techniques; Testing; Time; Tissue Growth; Treatment Side Effects; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; United States; VNTR; VNTR Loci; VNTR Region; VNTR Sequences; Variable Number of Tandem Repeats; Variable Tandem Repeats; Variation (Genetics); Walking; allelic variant; behavior intervention; behavioral intervention; body system; chronic disease/disorder; chronic disorder; clinical research site; clinical site; cytokine; daily living functionality; decline in function; depressive; depressive symptoms; design; designing; disease/disorder; elderly patient; environment effect on gene; experience; functional ability; functional capacity; functional decline; functional outcomes; functional status; gene environment interaction; genetic etiology; genetic mechanism of disease; genetic risk factor; genetic vulnerability; health related quality of life; heavy metal Pb; heavy metal lead; high risk; improved; inflammatory marker; inherited factor; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; interferon beta 2; interventional strategy; lung function; older patient; ontogeny; pathophysiology; performance tests; polymorphism; primary outcome; public health relevance; recruit; respiratory function; response; reuptake; secondary outcome; serotonin transporter; side effect; social role; sodium-dependent serotonin transporter; therapy adverse effect; treatment adverse effect",Depression and functional outcomes in COPD: Impact of genetics and inflammation," NARRATIVE Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States, is characterized by chronic, progressive worsening shortness-of-breath, cough and sputum production, and 25- 50% of patients will develop depressive symptoms. The overall goal of this proposal is to examine the impact of inflammation and genetic risk factors on depression in patients with moderate to severe COPD, and to assess the combined effects of inflammation, genetics, and depression on changes in functional outcomes. Understanding these relationships will in inform the development of more tailored medical and behavioral interventions to improve depression and functional outcomes in patients with COPD.",93146,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",A2,1,462849,
7780590,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL093269-01A2,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"KAO, HUNG-YING ;",7042547;,1R01HL093269,02/01/2010,01/31/2014,"Acute Promyelocytic Leukemia; Adhesions; Affect; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Blood Vessels; Blood monocyte; CHIP assay; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cellular Expansion; Cellular Growth; Cellular Migration; Cellular Proliferation; ChIP (chromatin immunoprecipitation); Chemicals; Complex; Cytokine Activation; Cytokine Receptors; Cytoplasm; DNA Sequence; Development; Dilatation; Dilatation - action; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drug or chemical Tissue Distribution; Electromagnetic Radiation, Ionizing; Embryo; Embryonic; Endothelial Cells; Fibroblasts; Gene Expression; Gene Targeting; Gene Transcription; Genetic Transcription; Goals; HA6116; HD4; HDAC; HDAC Proteins; HDAC-A; HDAC4; HDAC4 gene; HDACA; Histone Deacetylase; Histones; Human; Human, General; IFN; INFLM; In Vitro; Inducer of Promyelocytic Leukemia Protein; Infection; Inflammation; Inflammatory; Injury; Interferons; Interleukins; Intracellular Communication and Signaling; Ionizing radiation; KIAA0288; Knock-out; Knockout; Knockout Mice; LPS; Link; Lipopolysaccharides; MMP-10; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular Interaction; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Motility; Motility, Cellular; Murine; Mus; Muscle Cells; Muscle Cells, Mature; Myeloid Leukemia, Acute, M3; Myocytes; Nuclear; Nucleus; Null Mouse; Oxidative Stress; Pathway interactions; Play; Progranulocytic Leukemia; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Promyelocytic Leukemia Protein; Proteins; RNA Expression; RNA, Messenger; RNA, Small Interfering; Radiation-Ionizing Total; Receptors, Cytokine; Regulation; Reporter; Repression; Role; Rupture; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin Carcinogenesis; Small Inducible Cytokine A2; Small Interfering RNA; Stimulus; TNF-alpha; TRIM19; Targetings, Gene; Testing; Therapeutic; Tissue Distribution; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transfection; Tripartite Motif Protein TRIM19; Tube; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell; Virus; Viruses, General; angiogenesis; biological signal transduction; blood vessel disorder; cell growth; cell motility; chromatin immunoprecipitation; cytokine; derepression; experiment; experimental research; experimental study; extracellular; gene product; histone modification; human disease; in vivo; inhibitor; inhibitor/antagonist; interest; irradiation; mRNA; matrix metalloproteinase 10; member; migration; model organism; monocyte; novel; overexpression; pathway; promyelocytic leukemia; protein expression; public health relevance; research study; response; senescence; siRNA; social role; stromelysin 2; transcription factor; transcription factor PML; transin 2; tumor; ultraviolet; unspecified interleukin; vascular",Histone deacetylase 7 and its interacting proteins in endothelial cells," Narrative Endothelial cells reprogram their transcriptional network in response to cytokine stimulation such as tumor necrosis factor alpha (TNF¨), interleukin (IL), lipopolysacharide (LPS), or interferons (IFNs). Cytokine activation of endothelial cells initiates a series of responses including inflammation, cellular proliferation, apoptosis, and remodeling of blood vessels. The immediate receptors for these cytokines have been intensively studied, whereas the mechanisms underlying transcriptional regulation by downstream effectors remain largely unknown. We have identified histone deacetylase 7 (HDAC7) and promyelocytic leukemia (PML) protein as key mediators in TNF¨-induced altered gene expression in human umbilical vascular endothelial cells (HUVECs). We have also shown that PML and HDAC7 play a role in tube formation in HUVECs and human microvascular endothelial cells (HMVECs) in vitro. We will dissect the mechanisms and identify the effectors in TNF¨-mediated activation of ECs. Understanding the signaling that control inflammation, proliferation, apoptosis, and angiogenesis may have therapeutic implication in treating vascular diseases.",93269,VCMB,Vascular Cell and Molecular Biology Study Section,A2,1,392500,
7779705,R01,HL,1,,02/01/2010,01/31/2011,PA-08-083,1R01HL093386-01A2,,NHLBI:759148;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ANN ARBOR,UNITED STATES,MISCELLANEOUS,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"CLARK, NOREEN M;",1871496;,1R01HL093386,02/01/2010,01/31/2014,"0-11 years old; Accounting; Address; African American; Afro American; Afroamerican; Americas; Asthma; Belief; Black Populations; Black or African American; Bronchial Asthma; Care, Health; Caring; Child; Child Youth; Child health care; Childhood; Children (0-21); Clinical; Communication; Control Groups; Counseling; Cultural Diversity; Curriculum; Data; Dimensions; Education; Education, Medical, Continuing; Educational Curriculum; Educational aspects; Ethnic group; Fostering; Future; General Population; General Public; Goals; Guidelines; Health; Health behavior; Health, Child; Healthcare; Healthcare Systems; High Prevalence; Hispanic Populations; Hispanics; Hispanics or Latinos; Human, Child; Institution; Intervention; Intervention Strategies; Latino; Latino Population; Literature; Medical Records; Methods and Techniques; Methods, Other; Mink; Minority; Multiculturalism; New York; Outcome; PROV; Parents; Patients; Performance; Physicians; Population; Prevention program; Programs (PT); Programs [Publication Type]; Provider; Puerto Rican; QOL; Quality of life; Randomized Clinical Trials; Reporting; Research; Research Resources; Resources; Schools, Medical; Spanish Origin; Stereotyping; Survey Instrument; Surveys; Symptoms; Systems, Health Care; Techniques; Telephone Interviews; Therapeutic; Training; Training Programs; Trials, Randomized Clinical; Uncertainty; United States; Work; black American; children; clinical practice; continuing medical education; cultural competence; design; designing; doubt; expectation; experience; hispanic community; improved; interventional strategy; medical schools; patient population; pediatric; programs; racial and ethnic; racial/ethnic; response; satisfaction; skills; social; youngster",Improving Asthma Outcomes through Cultural Competence Training for Physicians,,93386,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",A2,1,759148,
7785124,R01,HL,1,,01/04/2010,12/31/2010,PA-07-070,1R01HL093457-01A2,,NHLBI:301000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SALT LAKE CITY,UNITED STATES,GENETICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"LALOUEL, JEAN-MARC ;",1869078;,1R01HL093457,01/04/2010,12/31/2010,"1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-; 2,6,8-Trihydroxypurine; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; ANF; ANH; ANP; Accounting; Age-Years; Aging; Albumins; Aldosterone; Angiotensin-Forming Enzyme; Angiotensinogen; Angiotensinogen (protein renin substrate); Angiotensinogenase; Animals; Atrial Natriuretic Factor; Atriopeptins; Auriculin; Autoregulation; BP control; Backcrossings; Blood Plasma; Blood Plasma Volume; Blood Pressure; Blood Pressure Monitors; Blood Pressure, High; Body Tissues; CDI1 Gene; CDK2-Associated Dual Specificity Phosphatase Gene; CDKN3; CDKN3 gene; CIP2 Gene; CREA; Chronic; Clinical; Clinical Management; Code; Coding System; Complex; Creatinine; Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase) Gene; Cyclin-Dependent Kinase Inhibitor 3 Gene; Cyclin-Dependent Kinase Interacting Protein 2 Gene; Cyclin-Dependent Kinase Interactor 1 Gene; Data; Development; Diagnosis; Diet; Dietary Sodium; Dietary intake; Disease; Disorder; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Environment; Essential Hypertension; Experimental Models; Experimental Models, Other; Feedback; Figs; Figs - dietary; Funding; Gender; Gene Expression; Gene Targeting; Gene variant; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Diversity; Genetic Variation; Genomics; Goals; Hereditary Disease; Homeostasis; Human; Human, General; Hypertensinogen; Hypertension; Infusion; Infusion procedures; Investments; KAP Gene; KAP1 Gene; Kidney; Kinase-Associated Phosphatase Gene; Knowledge; Lead; Life Style; Lifestyle; Link; Liver; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Mediating; Messenger RNA; Mice; Mice, Transgenic; Modeling; Models, Experimental; Molecular Disease; Murine; Mus; NIH; Na element; National Institutes of Health; National Institutes of Health (U.S.); Natriuretic Peptides, Atrial; Osmolalities; Pathogenesis; Patients; Pb element; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Plasma; Plasma Volume; Play; Population; Predisposition; Predisposition gene; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Proangiotensin; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Protocol; Protocols documentation; RNA, Messenger; Regulation; Relative; Relative (related person); Renal function; Renin; Renin-Angiotensin System; Renin-Substrate; Research; Research Specimen; Resistance; Reticuloendothelial System, Serum, Plasma; Rodent; Rodentia; Rodentias; Senescence; Serum, Plasma; Site; Sodium; Sodium, Dietary; Solid; Source; Specificity; Specimen; Sphygmomanometers, Continuous; Staging; Susceptibility; Susceptibility Gene; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic; Time; Tissues; Titrations; Transgenic Mice; Trioxopurine; Tubular; Tubular formation; UTRs; United States; United States National Institutes of Health; Universities; Untranslated Regions; Uric Acid; Urinary System, Kidney; Urinary System, Urine; Urine; Utah; Variant; Variation; Variation (Genetics); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weaning; Work; adult animal; adult youth; allelic variant; atrial natriuretic hormone; base; blood pressure control; blood pressure homeostasis; blood pressure regulation; body system, hepatic; design; designing; disease duration; disease length; disease/disorder; experiment; experimental research; experimental study; gene product; genetic disorder; genetic variant; heavy metal Pb; heavy metal lead; hereditary disorder; homologous recombination; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; illness length; juvenile animal; kidney function; mRNA; male; mature animal; organ system, hepatic; overexpression; predisposing gene; primary hypertension; public health relevance; renal; research study; resistant; response; senescent; spelling; urinary; young adult; young animal","Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender"," Narrative Summary Over 50% of the population of the United States have essential hypertension, or high blood pressure of unknown cause, by the time they reach 65 years of age, and only a fraction of these patients have their blood pressure under control. The renin-angiotensin system (RAS) is a major controller of blood pressure and of its relationship to dietary salt, but its function is complex because it involves overlapping circulating and tissue systems. We have shown that common genetic variants in the angiotensinogen gene (AGT), a component of the RAS, lead to increased plasma levels of the protein and predisposes to EH. As a result of its expression at multiple sites, AGT is involved in both systemic and renal function. We will use transgenic mice to manipulate expression of the gene at two major sites, namely the liver and the kidney, and test the relative significance of these two sources as a function of genetic background, gender, dietary salt, aging and renin regulation. Our goal is to advance the specificity of clinical management and treatment of EH.",93457,HM,Hypertension and Microcirculation Study Section,A2,1,301000,
7782902,R01,HL,1,,01/04/2010,11/30/2010,PA-07-070,1R01HL093463-01A1,,NHLBI:381250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBUS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"MAGALANG, ULYSSES J;PARINANDI, NARASIMHAM LAXMI (contact);",1890729;1919350 (contact);,1R01HL093463,01/04/2010,11/30/2013,"ACRP30 protein; Adipocytes; Adipose Cell; Adipose tissue; Affect; Airway Obstruction; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-atherogenic; Anti-diabetic Agents; Anti-inflammatory; Antiatherogenic; Antidiabetic Agents; Antidiabetic Drugs; Antiinflammatories; Antiinflammatory Agents; Apnea, Sleep; Attention; Biology; CPAP; CPAP Ventilation; Cardiac; Cardiac Failure Congestive; Cardiac infarction; Cardiomyopathies; Cardiovascular Diseases; Cells; Congestive Heart Failure; Continuous Positive Airway Pressure; Coupled; Data; Development; Dysfunction; Endocrine Glands; Endocrine Organs; Environment; Exposure to; Fat Cells; Fatty Tissue; Functional disorder; HTRPY; Heart; Heart Decompensation; Heart Failure, Congestive; Heart failure; Human; Human, General; Hypertrophy; Hypoxia; Hypoxic; Individual; Institutes; Insulin Resistance; Knowledge; Left; Link; Lipocytes; Lung; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medicine; Mice; Modeling; Molecular Weight; Murine; Mus; Muscle Cells; Muscle Cells, Mature; Mycocardium Disease; Myocardial; Myocardial Diseases; Myocardial Disorder; Myocardial Infarct; Myocardial Infarction; Myocardial depression; Myocardial dysfunction; Myocardiopathies; Myocytes; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Obesity; Obstructive Sleep Apnea; Ohio; Organism-Level Process; Organismal Process; Oxygen Deficiency; Patients; Peptides; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Physiopathology; Play; Pressure; Pressure- physical agent; Proteins; Regulation; Respiratory System, Lung; Risk; Risk Factors; Role; Science of Medicine; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Sleep Disorders; Sleep Hypopnea; Sleep-Disordered Breathing; Stimulus; Structure; Syndrome, Sleep Apnea, Obstructive; System; System, LOINC Axis 4; Time; Transgenic Organisms; Translational Research; Translational Research Enterprise; Translational Science; Universities; Ventricular; Zeugmatography; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adipose; adiposity; anti-diabetic drugs; antidiabetic; apM-1 protein; apM1 (adipose-specific) protein; attenuation; authority; cardiac failure; cardiac infarct; cardiovascular disorder; cardiovascular risk; cardiovascular risk factor; college; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; experiment; experimental research; experimental study; gene product; glucose transport; heart attack; heart infarct; heart infarction; human subject; improved; in vivo; insulin resistant; insulin sensitivity; model organism; mouse model; myocardium disorder; novel; obese; obese people; obese person; obese population; overexpression; pathophysiology; pressure; prevent; preventing; public health relevance; pulmonary; research study; sleep problem; social role; transgenic; translation research enterprise; treatment strategy; white adipose tissue; yellow adipose tissue","Intermittent hypoxia, adiponectin, and insulin resistance in cardiovascular risk"," Intermittent hypoxia associated with obstructive sleep apnea is a very common problem that is an important risk factor for cardiovascular disease. Knowledge of the mechanisms of how adiponectin protects against intermittent hypoxia-induced insulin resistance and associated myocardial dysfunction, may provide novel treatment strategies for patients with sleep apnea and cardiovascular disease.",93463,MIM,Myocardial Ischemia and Metabolism Study Section,A1,1,381250,
7792619,R01,HL,1,,01/04/2010,11/30/2010,PA-07-070,1R01HL094384-01A2,,NHLBI:351000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"STEMPIEN-OTERO, APRIL ;",2282116;,1R01HL094384,01/04/2010,11/30/2013,"Abbreviations; Accounting; Acute; Americas; Analysis, Data; Animal Model; Animal Models and Related Studies; Animals; Area; Arm; Arrhythmia; Autologous; Berlex brand of ferumoxides; Berlin blue; Biology; Bleeding; Blood Plasma; Blood Vessels; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cell Transplantation; Bone Marrow Cells; Bone Marrow Stem Cell; Bone Marrow Transplant; Bone Marrow Transplantation; CD34; CD34 gene; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cardiac Failure Congestive; Cardiac Remodeling, Ventricular; Cardiomyopathies; Cell Fraction; Cell Therapy; Cell/Tissue, Immunohistochemistry; Cells; Characteristics; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Congestive Heart Failure; Data; Data Analyses; Devices; Disease; Disorder; Endothelial Cells; Endothelium; Endothelium, Vascular; Enrollment; Ethics Committees, Research; Evaluation; Exhibits; Feridex; Fibrosis; Funding; Generations; Grafting, Bone Marrow; Grafting, Heart; Grant; HPCA1; Harvest; Heart; Heart Arrhythmias; Heart Decompensation; Heart Diseases; Heart Failure, Congestive; Heart Muscle tissue; Heart Transplantation; Heart failure; Hemorrhage; Histologic; Histologically; Histology; Human; Human Subject Research; Human, General; IHC; IRBs; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Infection; Inflammatory; Injection of therapeutic agent; Injections; Injury; Institutional Review Boards; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Label; Left; MR Imaging; MR Tomography; MRI; MRI Scans; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant; Malignant - descriptor; Man (Taxonomy); Man, Modern; Marrow; Marrow Transplantation; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Modality; Modeling; Mononuclear; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Muscle, Cardiac; Muscle, Heart; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardial Ischemia; Myocardial Remodeling, Ventricular; Myocardial tissue; Myocardiopathies; Myocardium; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Patients; Perfusion; Phase; Phenotype; Pilot Projects; Plasma; Population; Process; Progenitor Cells; Protocol; Protocols documentation; Prussian blue; Randomized; Refractory; Research Ethics Committees; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Serum, Plasma; Safety; Sampling; Scans, MRI; Serum, Plasma; Site; Staging; Staining method; Stainings; Stains; Stem cells; Structure; Testing; Therapy, Cell; Time; Tissues; Transplantation; Transplantation, Bone Marrow Cell; Transplantation, Cardiac; Universities; Upper arm; Vascular Endothelium; Ventricle Remodeling; Ventricular; Ventricular Remodeling; Washington; Zeugmatography; base; blood loss; cardiac failure; cardiac graft; cardiac muscle; cell type; cell-based therapy; clinical investigation; cofactor; colcothar; conventional therapy; density; disease/disorder; enroll; ferric ferrocyanide; ferric oxide; ferrihexacyanoferrate; ferrotsin; heart disorder; heart ischemia; heart muscle; heart transplant; human study; human subject; imaging; implantation; improved; in vivo; injured; insight; iron oxide; macrophage; model organism; myocardial ischemia/hypoxia; myocardial remodeling; myocardium disorder; myocardium ischemia; novel; paracrine; particle; patient population; pilot study; public health relevance; randomisation; randomization; randomly assigned; red iron oxide; response; transdifferentiation; translational study; transplant; treatment site; vascular; ventricular assist device",Fate of Bone Marrow Cells Injected into the Human Heart, Congestive heart failure is a major cause of morbidity and mortality in America. There are currently few therapies besides cardiac transplantation for end-stage heart failure. These studies will increase understanding of how bone marrow derived cells may be used to treat congestive heart failure.,94384,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,A2,1,351000,
7783134,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL094677-01A1,,NHLBI:434063;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"ROSENZWEIG, ANTHONY ;",1888424;,1R01HL094677,01/15/2010,12/31/2013,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Action Potentials; Address; Antimorphic mutation; Arrhythmia; Binding; Binding (Molecular Function); Body Tissues; Cardiac; Cardiac Arrhythmia; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Signaling; Characteristics; Chronic; Data; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; EC 2.7; Electrophysiology; Electrophysiology (science); Exhibits; Fibrosis; Functional disorder; Generalized Growth; Genetic; Genetics-Mutagenesis; Genomics; Goals; Growth; HTRPY; Heart; Heart Arrhythmias; Heart Hypertrophy; Heart failure; Heart myocyte; Hypertrophy; In Vitro; Intracellular Communication and Signaling; Investigation; Ion Channel; Ion Channels, Potassium; Ion Channels, Sodium; Ionic Channels; K channel; Kinases; Kinetic; Kinetics; Mammals, Mice; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane Channels; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Mutagenesis; Myocardium; Myocytes, Cardiac; Na element; Neurophysiology / Electrophysiology; Optics; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Patients; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Physiopathology; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Potassium Channel; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteomics; PtdIns 3-Kinase; Relative; Relative (related person); Risk; Role; SGK1 protein; Serine Kinase; Serine-Threonine Kinases; Serum-glucocorticoid-regulated kinase 1; Sgk protein; Signal Transduction; Signal Transduction Systems; Signaling; Sodium; Sodium Channel; System; System, LOINC Axis 4; Testing; Threonine Kinase; Tissue Growth; Tissues; Transgenic Mice; Transphosphorylases; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; base; biological signal transduction; cardiac failure; cardiac hypertrophy; cardiac muscle; cardiac rhythm; cardiomyocyte; constriction; drug development; gene product; heart muscle; heart rhythm; in vivo; inhibitor; inhibitor/antagonist; interest; novel; novel therapeutic intervention; ontogeny; pathophysiology; pathway; public health relevance; serum and glucocorticoid-regulated kinase; social role; therapeutic target",Role of serum- and glucocorticoid-regulated kinase-1 in electrical remodeling," Project Narrative: Patients with heart failure or thickened (hypertrophied) heart muscle are at increased risk for heart rhythm problems, some of which can be fatal. Our goal is to understand the role of a specific molecule (SGK1) in the development of heart rhythm problems in this context. We will study this question in mice in which we have genetically activated or inhibited this molecule specifically in heart muscle cells. Our initial results suggest that activating this molecule promotes rhythm problems, whereas inhibiting it has beneficial effects. While we think it is important in general to understand mechanisms underlying heart rhythm problems, this molecule is particularly interesting because it belongs to a class of molecules that have previously been successfully targeted for drug development. Thus understanding SGK1's role in the heart could have important practical implications, and the current application would help advance our understanding of the potential of SGK1 as a therapeutic target.",94677,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",A1,1,434063,
7760425,R01,HL,1,,01/15/2010,12/31/2010,PAR-07-102,1R01HL095454-01A1,,NHLBI:365000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PORTLAND,UNITED STATES,BIOLOGY,01,052226800,US,OR,97207,PORTLAND STATE UNIVERSITY,"PODRABSKY, JASON EARL;",9037445;,1R01HL095454,01/15/2010,12/31/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Acids; Active Oxygen; Adaptation, Physiological; Adaptations, Physiologic; Address; Aerobic; Affect; Alanine; Alanine, L-Isomer; Amaze; Aminalon; Aminalone; Animals; Anoxia; Apoplexy; Atlantic Killifish; Biochemical; Biochemical Pathway; Biology; Body Tissues; Brain; Butanoic acid, 4-amino-; C element; Carbon; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cell Death; Cell Function; Cell Process; Cell physiology; Cell/Tissue, Immunohistochemistry; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Characteristics; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Citric Acid Cycle; Coupled; Creatine Phosphate; Cyprinodontidae; Cytoplasm; Data; Death; Detection; Development; Diapause; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Engineering; Engineerings; Enzymes; Event; Exhibits; Exposure to; Fishes; Fluorescent Probes; Fundulus heteroclitus; GABA; GTP; Generations; Genetic; Genomics; Glycine, N-(imino(phosphonoamino)methyl)-N-methyl-; Glycolysis; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; HPLC; Heart; Heart Diseases; High Pressure Liquid Chromatography; Hour; Human; Human Development; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Intermediary Metabolism; Killifish; Killifishes; Kinetic; Kinetics; Knowledge; Krebs Cycle; L-Alanine; Light; METBL; Man (Taxonomy); Man, Modern; Mediating; Membrane Potentials; Metabolic; Metabolic Networks; Metabolic Pathway; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Mitochondria; Modeling; Molecular; Morbidity; Morbidity - disease rate; Myocardial Infarct; Myocardial Infarction; Natural Selections; Nature; Nervous System, Brain; O element; O2 element; Organism; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); Oxygen; Oxygen Radicals; PEPCK; Pattern; Peptide Biosynthesis, Ribosomal; Phosphates; Phosphocreatine; Phosphoenolpyruvate Carboxylase; Phosphorylcreatine; Photoradiation; Physiologic; Physiological; Physiological Adaptation; Physiology; Pro-Oxidants; Probes, Fluorescent; Process; Production; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Pupfishes; Reactive Oxygen Species; Recovery; Reporting; Resting Potentials; Role; Sampling; Selections, Natural; Source; Stroke; Subcellular Process; Succinates; System; System, LOINC Axis 4; TCA cycle; Testing; Time; Tissues; Transmembrane Potentials; Tricarboxylic Acid Cycle; Vascular Accident, Brain; Vertebrate Animals; Vertebrates; Writing; Yolk Cell; base; brain attack; brain tissue; cardiac infarct; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; deprivation; embryo cell; enzyme activity; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; heart attack; heart cell; heart disorder; heart infarct; heart infarction; inhibitor; inhibitor/antagonist; inorganic phosphate; living system; measurement of metabolism; metabolomics; methylxanthine; mitochondrial; mitochondrial membrane; mummichog; necrocytosis; novel; oxidation; phosphoenolpyruvate carboxykinase; prevent; preventing; protein synthesis; public health relevance; research study; response; social role; stroke; vertebrata",The Role of phosphoenolpyruvate carboxykinase and reactive oxygen species in the," Heart disease and stroke are responsible for the vast majority of deaths in the developed world. The extreme sensitivity of human heart and brain tissue to lack of oxygen is poorly understood at the cellular level. By understanding the cellular mechanisms that support extreme anoxia tolerance in embryos of the annual killifish, Austrofundulus limnaeus, we may be able to develop treatments to mediate or prevent the damaging affects of heart attacks and strokes to humans.",95454,ZRG1,Special Emphasis Panel,A1,1,365000,
7778087,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL095541-01A1,,NHLBI:380704;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"LIU, ZHENG ;",9459513;,1R01HL095541,01/15/2010,12/31/2013,"3-D structure; 3-dimensional structure; 3D structure; Amino Acids; Arrhythmogenic Right Ventricular Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Ca Release Channel-Ryanodine Receptor; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium-Ryanodine Receptor Complex; Calmodulin; Cardiac; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chimera Protein; Chimeric Proteins; Coagulation Factor IV; Coupling; Cryo-electron Microscopy; Cryoelectron Microscopy; Death; Death, Sudden, Cardiac; Disorder of muscle, unspecified; Dissociation; Drugs; Dysfunction; Electron Cryomicroscopy; FK-506-Binding Protein; FK506 Binding Proteins; FKBP; FKBP Rotamase; FRET; Factor IV; Fluorescence Resonance Energy Transfer; Functional disorder; Fusion Protein; GFP; Goals; Green Fluorescent Proteins; Heart Diseases; Heart failure; Hereditary; Inherited; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Investigation; Ion Channel; Ionic Channels; KBP; Knowledge; Laboratories; Location; Maps; Mediating; Medication; Membrane; Membrane Channels; Methods and Techniques; Methods, Other; Models, Structural; Molecular Interaction; Mortality; Mortality Vital Statistics; Movement; Muscle; Muscle Disease; Muscle Disorders; Muscle Tissue; Muscle disease or syndrome; Muscle, Cardiac; Muscle, Heart; Muscular Diseases; Myocardium; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiopathology; Play; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Receptors, Ryanodine; Regulation; Research; Resolution; Roentgen Rays; Role; RyR2; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Sarcoplasmic Reticulum; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Structural Models; Structure; System; System, LOINC Axis 4; Tachycardia, Ventricular; Tacrolimus Binding Proteins; Techniques; Testing; Transmembrane Protein; United States; Ventricular Tachycardia; Work; X-Radiation; X-Rays; Xrays; aminoacid; base; biological signal transduction; body movement; cardiac failure; cardiac muscle; computer imaging; cryoEM; design; designing; digital imaging; drug/agent; effective therapy; fluorophore; gene product; heart disorder; heart muscle; image processing; innovate; innovation; innovative; membrane structure; molecular mass; muscular disorder; new therapeutics; next generation therapeutics; novel; novel therapeutics; particle; pathophysiology; public health relevance; screening; screenings; social role; three dimensional structure; tool",Structural Basis of Dysfunctional Calcium Release Channels in Heart Disease," PROJECT NARRATIVE Heart disease is the leading cause of natural death in the United States. Abnormal calcium release through a dysfunctional cardiac muscle ryanodine receptor has been implicated to certain type of sudden cardiac death and heart failure. The proposed research will investigate the structural basis for the dysfunctional cardiac ryanodine receptors. The information will help us to understand the role of ryanodine receptors in excitation-contraction coupling mechanisms, and how ryanodine receptors dysfunction leads to cardiac muscle diseases, which in turn should allow rational design of novel therapeutic strategies.",95541,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",A1,1,380704,
7779910,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095552-01A1,,NHLBI:390000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,ANESTHESIOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"PASCHEN, WULF ;",8351291;,1R01HL095552,02/01/2010,01/31/2013,"21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Adult; Adverse effects; Age; Ammon Horn; Animals; Apoplexy; Asystole; Basic Mechanisms of SUMOylation; Blotting, Western; Brain; Brain region; Cardiac; Cardiac Abnormalities; Cardiac Arrest; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cardiopulmonary Bypass; Cardiovascular; Cardiovascular Body System; Cardiovascular Surgical Procedures; Cardiovascular system; Cardiovascular system (all sites); Cell/Tissue, Immunohistochemistry; Cells; Cellular Stress; Cellular injury; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Childhood; Clinical; Congenital Heart Defects; Cornu Ammonis; Encephalon; Encephalons; Exposure to; HMG-20; Heart Abnormalities; Heart Arrest; Heart Defects, Congenital; Heart Malformation; Heart-Lung Bypass; Hibernation, Artificial; High Mobility Protein 20; Hippocampus; Hippocampus (Brain); Human, Adult; Hypothermia; IHC; Immune Precipitation; Immunohistochemistry; Immunohistochemistry Staining Method; Immunoprecipitation; Injury; Interruption; Ischemia; Kidney; Lentivirinae; Lentivirus; Location; Micro RNA; MicroRNAs; Nervous System, Brain; Nuclear Translocation; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organ System, Cardiovascular; Outcome; Pathologic Processes; Pathological Processes; Pathway interactions; Patients; Perioperative; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Procedures; Process; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteomics; Recovery; Research; Resistance; Risk; Role; Signal Transduction Pathway; Stroke; Subfamily lentivirinae; Sumoylation Pathway; Surgical; Surgical Interventions; Surgical Procedure; Therapeutic; Therapeutic Intervention; Time; Treatment Side Effects; Ubiquitin; Urinary System, Kidney; Vascular Accident, Brain; Vascular blood supply; Vascular, Heart; Virus; Virus-Lenti; Viruses, General; Western Blotting; Western Blottings; Western Immunoblotting; Work; adult human (21+); blood supply; brain attack; cardiovascular surgery; cell damage; cell injury; cell transduction; cellular transduction; cerebral vascular accident; circulatory system; design; designing; gene product; genetically modified cells; glucose metabolism; heart bypass; heart defect; hippocampal; hypothermia, induced; hypothermia, natural; induced hypothermia; interest; intervention therapy; miRNA; natural hypothermia; neonate; new approaches; novel approaches; novel strategies; novel strategy; pathway; pediatric; protective effect; protein activation; protein blotting; public health relevance; renal; resistant; side effect; social role; stroke; surgery; therapy adverse effect; transcription factor; transduced cells; treatment adverse effect; vascular supply",SUMO Conjugation and Deep Hypothermia-Induced Organ Protection," Circulatory arrest is required for various surgeries, including aortic surgery or correction of congenital heart defects in the neonates. To protect organs from damage caused by transient ischemia, circulatory arrest is carried out under deep hypothermic conditions. This proposal focuses on the hypothesis that activation of small ubiquitin-like modifier (SUMO) conjugation of target proteins plays a major role in deep hypothermia- induced organ protection. If our hypothesis proves valid, SUMO conjugation could prove to be a very exciting new target for therapeutic intervention by providing a means of increasing the resistance of organs to a transient interruption of blood supply.",95552,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1,1,390000,
7792312,R01,HL,1,,02/01/2010,11/30/2010,PA-07-070,1R01HL095566-01A2,,NHLBI:372500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW ORLEANS,UNITED STATES,PHYSIOLOGY,02,053785812,US,LA,70118,TULANE UNIVERSITY OF LOUISIANA,"MATROUGUI, KHALID ;",8243671;,1R01HL095566,02/01/2010,11/30/2014,"2,2,6,6-tetramethyl-4-piperidinol-N-oxyl; 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine; 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical; 4-hydroxy-3-methoxyacetophenone; 4-hydroxy-TEMPO; ADP-Ribosyltransferase (Polymerizing); ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Adenoviridae; Adenoviruses; Arterioles; Blood Vessels; CCAAT-Box Binding Transcription Factor; CTF; Caliber; Cardiac Diseases; Cardiac Disorders; Cardiovascular Diseases; Causality; Cell Communication and Signaling; Cell Signaling; Cellular Expansion; Cellular Growth; Cessation of life; Chemosensitization; Chemosensitization/Potentiation; Coenzyme II; Complex; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; DNA Molecular Biology; Data; Death; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetic Angiopathies; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Diabetic mouse; Diameter; Disease; Disorder; Dysfunction; EGFR; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; Endothelial Cells; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Etiology; Functional disorder; Generations; Goals; HEK3; HER1; HOTMP; Heart; Heart Diseases; HuB219; HyTEMPO; Immunoglobulin Enhancer-Binding Protein; In Vitro; Intracellular Communication and Signaling; Investigation; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Knockout Mice; LEP-R; LEPR; LEPR Protein; Laboratories; Leiomyocyte; Link; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Molecular Biology; Morbidity; Morbidity - disease rate; Murine; Mus; Myocardial Ischemia; Myocytes, Smooth Muscle; NAD phosphate; NAD(H) phosphate; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; NADH phosphate; NADP; NADPH; NF-I Protein; NF-kB; NF-kappa B; NF-kappaB; NFI; NFI Transcription Factor; NFKB; NIDDM; Nicotinamide-Adenine Dinucleotide Phosphate; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nuclear; Nuclear Factor I; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; OB Receptor; OB-R; Oxidative Stress; PARP Polymerase; PARP-1, mouse; PARS; PEG-SOD; PTK; Pathology; Pathway interactions; Pharmacology; Phosphorylation; Physiopathology; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Potentiation; Pressure; Pressure- physical agent; Prevalence; Production; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; RNA, Small Interfering; Receptor Gene; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Relaxation; Research; Research Personnel; Researchers; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Stream; Structure of arteriole; Superoxide Anion; Superoxide Radical; Superoxides; T2D; T2DM; TGGCA-Binding Protein; TMPN; TPL cpd; Technology; Testing; Transcription Factor NF-kB; Transforming Growth Factor alpha Receptor; Triphosphopyridine Nucleotide; Type 2 diabetes; Type II diabetes; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell; acetovanillone; adult onset diabetes; apocynin; apocynine; arteriole; biological signal transduction; blood vessel disorder; burden of disease; burden of illness; c-erbB-1; c-erbB-1 Protein; cardiovascular disorder; cell growth; constriction; db/db mouse; diabetes; diabetic; diabetic patient; disease burden; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; heart disorder; heart ischemia; hydroxyaryl protein kinase; improved; in vivo; insight; intervention development; kappa B Enhancer Binding Protein; ketosis resistant diabetes; leptin receptor; leptin-binding protein; maturity onset diabetes; microvascular complications; microvascular complications of diabetes; microvascular disease; migration; mimetics; mouse model of diabetes; myocardial ischemia/hypoxia; myocardium ischemia; nitroxyl 2; nuclear factor 1; nuclear factor kappa beta; p65; pathophysiology; pathway; poly ADP polymerase; poly ADP ribose synthetase; poly(ADP-ribose)polymerase-1, mouse; polyethylene glycol-superoxide dismutase; pressure; proto-oncogene protein c-erbB-1; public health relevance; response; siRNA; tanol; tempol; therapy development; treatment development; tyrosyl protein kinase; vascular; years of life lost to disability; years of life lost to disease",Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes, Project narrative: Type 2 diabetes mellitus and cardiovascular disease contribute to a high proportion of the burden of disease in the UNITED STATES. The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes.,95566,VCMB,Vascular Cell and Molecular Biology Study Section,A2,1,372500,
7779918,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL095608-01A1,,NHLBI:368750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLESTON,UNITED STATES,SURGERY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SPINALE, FRANCIS G;",1885383;,1R01HL095608,01/15/2010,12/31/2013,"ATP-protein phosphotransferase; Address; Affect; Animal Model; Animal Models and Related Studies; Binding; Binding (Molecular Function); Biological; Blood flow; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cardiac; Cardiac infarction; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Country; Dysfunction; ECM; Enzymes; Esteroproteases; Event; Extracellular Matrix; FLR; Failure (biologic function); Family suidae; Fibroblasts; Functional disorder; Healed; Heart failure; Intention; Interruption; Intracellular Communication and Signaling; Ischemia; Ischemia-Reperfusion Injury; Isoforms; Lentiviral Vector; Lentivirus Vector; MMP-14 gene product; MMP-X1; MMP14; MMP14 gene product; MMP14 protein, human; MMPs; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Matrix Metalloproteinase-14; Matrix Metalloproteinases; Measures; Mediating; Membrane; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Methods; Microdialysis; Modeling; Modification; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardium; Myocytes; Outcome; PKC; Pathologic Processes; Pathological Processes; Pathway interactions; Patients; Peptidases; Peptide Hydrolases; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Physiopathology; Pigs; Play; Process; Proteases; Protein Isoforms; Protein Kinase; Protein Kinase C; Protein Phosphorylation; Proteinases; Proteolytic Enzymes; Pump; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Residual; Residual state; Risk; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Suidae; Swine; System; System, LOINC Axis 4; Testing; biological signal transduction; cardiac failure; cardiac infarct; cardiac muscle; clinical relevance; clinically relevant; coronary attack; coronary infarct; coronary infarction; disability; extracellular; failure; glycogen synthase a kinase; healing; heart attack; heart infarct; heart infarction; heart muscle; human MMP14 protein; hydroxyalkyl protein kinase; interstitial; membrane structure; model organism; new therapeutic target; pathophysiology; pathway; phosphorylase b kinase kinase; porcine; public health relevance; reperfusion; social role; suid; trafficking",Myocardial Protection and Matrix Proteases," Project Narrative: One of the most common causes of death and disability in this country is from a heart attack; damage to the heart muscle. We have identified that a specific membrane bound enzyme is upregulated following a heart attack. Our intention is to understand how increased levels of this membrane enzyme can contribute to poor outcomes following a heart attack, and more importantly develop strategies to regulate this enzyme. These results will help develop new tests and treatments for patients suffering from heart failure after a heart attack.",95608,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1,1,368750,
7783163,R01,HL,1,,01/18/2010,12/31/2010,PA-07-070,1R01HL095699-01A1,,NHLBI:425000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"SPENCER, LISA ANN;",8904038;,1R01HL095699,01/18/2010,12/31/2014,"1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydroaminoacridine; 9-Amino-1,2,3,4-Tetrahydroacridine; APC; ATGN; Acidophilic Leukocyte; Airway Hyper-responsiveness; Allergy; Antigen-Presenting Cells; Antigens; Asthma; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Blood Eosinophil; Blood leukocyte; Bronchial Asthma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Cells; Cells, CD4; Cellular Infiltrate; Chemotaxis; Cytokine Signal Transduction; Cytokine Signaling; Data; Development; Disease; Disease Progression; Disorder; Eosinophilia; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Goals; Human; Human, General; Hypersensitivity; IL-4; IL4; IL4 Protein; Immune; Immunity; Immunologic Accessory Cells; Immunomodulation; Inflammatory; Interleukin-4; Interleukin-4 Precursor; Intracellular Communication and Signaling; Investigation; Investigators; Laboratories; Lead; Length of Life; Leucocytic infiltrate; Leukocytes; Ligands; Longevity; Lung; Lung diseases; Lymphocyte Stimulatory Factor 1; MCGF-2; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Marrow leukocyte; Mast Cell Growth Factor-2; Mediating; Mice; Microscopic; Monocytes / Macrophages / APC; Murine; Mus; Notch Signaling Pathway; Ovalbumin; Pathogenesis; Pathway interactions; Pb element; Phase; Proteolysis and Signaling Pathway of Notch; Pulmonary Diseases; Pulmonary Disorder; Receptor Activation; Receptor Protein; Research Design; Research Personnel; Researchers; Resolution; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Role; Shapes; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Stimulus; Study Type; T-Cell Growth Factor 2; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Tacrine; Tetrahydroaminoacridine; Thymus-Dependent Lymphocytes; White Blood Cells; White Cell; accessory cell; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway remodeling; asthmatic airway; base; biological signal transduction; cytokine; design; designing; disease/disorder; eosinocyte; eosinophil; heavy metal Pb; heavy metal lead; helper T cell; immune modulation; immunogen; immunologic reactivity control; immunoregulation; in vivo; insight; life span; lifespan; lung disorder; mouse model; new therapeutic target; notch; notch protein; notch receptors; novel; pathway; public health relevance; pulmonary; receptor; social role; study design; therapeutic target; thymus derived lymphocyte; white blood cell; white blood corpuscle",Notch signaling-mediated functions of airway eosinophils in lung disease," Project Narrative Asthma is a highly prevalent and costly disease. Eosinophils, innate immune leukocytes associated with asthma, allergies and other diseases, are the predominant cellular infiltrate in asthmatic airways. This proposal is designed to elucidate the mechanistic basis of eosinophil functions leading to asthma exacerbation. These studies may lead to the development of novel, targeted therapeutic approaches.",95699,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",A1,1,425000,
7783171,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL095712-01A1,,NHLBI:428125;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"PU, WILLIAM T;",2111949;,1R01HL095712,01/15/2010,12/31/2013,"21+ years old; Adult; Agonist; Autoregulation; Binding; Binding (Molecular Function); Binding Sites; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Signaling; Cells; Chromatin; Chromatin Structure; Combining Site; Complex; Coronary; Cues; DNA; DNA Binding; DNA Binding Interaction; DNA Packaging; Data; Deoxyribonucleic Acid; Developed Countries; Developed Nations; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; E2A; E2A Immunoglobulin Enhancer Binding Factors E12/E47 Gene; Environment; FLR; Failure (biologic function); GATA-4 protein; GATA-binding protein 4; GATA4 protein; GATA4 transcription factor; Gene Expression; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Materials; Genetic Transcription; Genome; Growth; HDAC; HDAC Proteins; HTRPY; Heart; Heart Diseases; Heart Hypertrophy; Heart failure; Heart myocyte; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Histone Deacetylase; Histones; Homeostasis; Human, Adult; Hypertrophy; ITF1; Industrialized Countries; Industrialized Nations; Intracellular Communication and Signaling; Knowledge; Lead; MEF-2A; MEF2A; Mammals, Mice; Materials, Genetic; Measures; Mediating; Methylation; Mice; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocytes; Myocytes, Cardiac; Neonatal; Pathogenesis; Pb element; Phenotype; Physiological Homeostasis; Polycomb; Programs (PT); Programs [Publication Type]; Protein Methylation; RNA Expression; Reactive Site; Recruitment Activity; Regulation; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Symptoms; TCF3; TCF3 gene; Targetings, Gene; Testing; Time; Tissue Growth; Transcription; Transcription, Genetic; Work; Work Load; Workload; adult human (21+); biological signal transduction; cardiac failure; cardiac hypertrophy; cardiogenesis; cardiomyocyte; chromatin remodeling; cofactor; disease/disorder; extracellular; failure; heart development; heart disorder; heart function; heavy metal Pb; heavy metal lead; improved; insight; muscle enhancer factor-2A; novel; novel therapeutic intervention; ontogeny; postnatal; programs; protein complex; public health relevance; recruit; response; social role; transcription factor",Regulation of Heart Function by a Gata4-Fog2 transcriptional complex," Narrative  Heart failure is the leading cause of morbidity and mortality in industrialized nations. Current treatments can slow the progression of heart failure and reduce the symptoms, but cannot rev- erse its course. One of the main contributors to the progression of heart failure is altered gene expression. While research in the last 20 years has identified many key factors that control gene expression in the failing heart, little is known about how they work. Research is also beginning to show that the packaging of genetic material inside the cell profoundly influences gene expres- sion. However, understanding of how the packaging responds to signals from outside the cell, such as increased workload, are not well understood. In this proposal, we study how one key regulator factor, GATA4, controls gene expression and how it modifies genetic packaging in re- sponse to the cell's environment. This knowledge may lead to improved therapies that can rev- erse gene expression changes and disease course in heart disease.",95712,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",A1,1,428125,
7780498,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095785-01A1,,NHLBI:765887;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MEMPHIS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"KLESGES, ROBERT C;",1866443;,1R01HL095785,02/01/2010,01/31/2015,"21+ years old; Abstinence; Active Follow-up; Adult; Air; American; Armed Forces Personnel; Booklets; Brochures; Cessation of smoking; Country; Human, Adult; Internet; Intervention; Intervention Strategies; Jail; Knowledge; Length of Stay; Maintenance; Maintenances; Methods; Military; Military Personnel; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Number of Days in Hospital; Pamphlets; Participant; Phone; Premature Mortality; Prevalence; Prevention of relapse; Printing; Prisons; Programs (PT); Programs [Publication Type]; Public Health; Randomized; Recruitment Activity; Relapse; Research; Sampling; Series; Smoke; Smoker; Smoking; Telephone; Testing; Time; Tobacco; Training; United States; WWW; adult human (21+); cease smoking; cigarette smoking; design; designing; disorder later incidence prevention; follow-up; hospital days; hospital length of stay; hospital stay; interventional strategy; involuntary smoking; population based; prevent; preventing; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; primary outcome; programs; public health medicine (field); public health relevance; quit line; quitline; randomisation; randomization; randomly assigned; recruit; secondary outcome; self help; smoke cigarette; smoking cessation; web; world wide web",Preventing Relapse Following Involuntary Smoking Abstinence," 7. Project Narrative  Despite large campaigns, over 22% of adult Americans smoke. The vast majority of people try to quit smoking on their own but most fail at these attempts. The current study will test ways of helping people who have quit involuntarily to maintain their abstinence. Since smoking is the #1 cause of premature mortality and morbidity in this country, the public health significance of this project is high.",95785,ZRG1,Special Emphasis Panel,A1,1,765887,
7781877,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095786-01A1,,NHLBI:362534;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLLEGE STATION,UNITED STATES,OTHER BASIC SCIENCES,17,141582986,US,TX,77845,TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR,"BAYLESS, KAYLA J;",6844434;,1R01HL095786,02/01/2010,01/31/2015,"21+ years old; 3D modeling; Address; Adult; Angiogenic Factor; Angiogenic Switch; Biochemical; Blood Vessels; Blood capillaries; Body Tissues; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chronic; Cleaved cell; Communication; Cues; DNA Sequence Rearrangement; Desminase; Dimensions; EC 2.7; Economic Burden; Endothelial Cells; Environment; Equilibrium; Esteroproteases; Event; Exhibits; Factor, Angiogenesis; Fibroblast Intermediate Filament Proteins; Future; GFAC; Generalized Growth; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, Adult; Human, General; IFP; Image; In Vitro; Injury; Intermediate Filament Proteins; Intermediate Filaments; Intracellular Communication and Signaling; Invaded; Isoforms; Kinases; Knowledge; Lipids; MMP-14 gene product; MMP-X1; MMP14; MMP14 gene product; MMP14 protein, human; MMPs; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-14; Matrix Metalloproteinases; Mechanics; Membrane; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Mice, Transgenic; Molecular; Monitor; Motility; Motility, Cellular; Murine; Mus; Organism; Papain-Like Cysteine Protease; Peptidases; Peptide Hydrolases; Phenotype; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Population; Process; Production; Proteases; Protein Cleavage; Protein Isoforms; Protein Phosphorylation; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Rearrangement; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Structure; System; System, LOINC Axis 4; Time; Tissue Growth; Tissues; Transgenic Mice; Transphosphorylases; Vimentin; Wound Healing; Wound Repair; adult human (21+); angiogenesis; balance; balance function; base; biological signal transduction; capillary; cell motility; cleaved; experiment; experimental research; experimental study; gene product; human MMP14 protein; imaging; improved; in vivo; in vivo Model; innovate; innovation; innovative; insight; interdisciplinary approach; living system; membrane structure; metalloproteinase (general); migration; novel; ontogeny; public health relevance; regenerate new tissue; regenerating damaged tissue; research study; response; shear stress; social; three-dimensional modeling; tissue regeneration; tissue repair; vascular; wound; wound vascularization",Mechanisms of Angiogenic Switch Activation During Wound  Repair," PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Chronic wounds elicit significant social and economic burdens; therefore, a complete understanding of these events is warranted. This proposal will significantly advance our understanding of how various physiological forces and biochemical signals initiate new blood vessel growth, which is a required step in wound healing. Such knowledge will ultimately aid to decrease the socio-economic burdens associated with aberrations or deficiencies in the process.",95786,VCMB,Vascular Cell and Molecular Biology Study Section,A1,1,362534,
7781214,R01,HL,1,,01/12/2010,11/30/2010,PA-07-070,1R01HL095787-01A1,,NHLBI:387500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"FEOKTISTOV, IGOR ;",1959527;,1R01HL095787,01/12/2010,11/30/2013,"21+ years old; Acute myocardial infarct; Acute myocardial infarction; Address; Adenosine; Adenosine A(2B) Receptor; Adenosine A2B Receptor; Adult; Affinity; Angiogenic Factor; Animal Model; Animal Models and Related Studies; Applications Grants; Autologous; Binding; Binding (Molecular Function); Blood Vessels; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bone Marrow Stem Cell; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cardiac; Cardiovascular Diseases; Catenin, Beta-1; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Proliferation Regulation; Cell Signaling; Cell Therapy; Cell Transplants; Cell surface; Cells; Cellular Proliferation; Cellular injury; Cessation of life; Coronary Circulation; Death; Disease; Disorder; Factor, Angiogenesis; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Generalized Growth; Goals; Grant Proposals; Grants, Applications; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heart; Homing; Human, Adult; Hypoxia; Hypoxic; Injury; Intracellular Communication and Signaling; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Knowledge; Modeling; Molecular; Molecular Interaction; Mononuclear; Mother Cells; Muscle, Cardiac; Muscle, Heart; Myocardial Ischemia; Myocardium; Natural regeneration; Nucleosides; Organ; Oxygen Deficiency; P1 Purinoceptors; PRO2286; Pathway interactions; Physiologic; Physiological; Production; Progenitor Cells; Property; Property, LOINC Axis 2; Purinergic P1 Receptors; Receptor Protein; Receptors, Adenosine; Receptors, Purinergic P1; Recovery; Regeneration; Regulation; Research; Reticuloendothelial System, Bone Marrow; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Testing; Therapeutic Effect; Therapy, Cell; Time; Tissue Growth; Tissues; Transplants, Cell; United States; VEGFs; Vascular Endothelial Growth Factors; Vegf; adult human (21+); adult stem cell; base; beta catenin; biological signal transduction; cardiac muscle; cardiovascular disorder; cell damage; cell injury; cell-based therapy; disability; disease/disorder; extracellular; heart ischemia; heart muscle; improved; in vivo; interstitial; model organism; myocardial ischemia/hypoxia; myocardium ischemia; neovascularization; novel; ontogeny; paracrine; pathway; preclinical study; public health relevance; receptor; regenerate; social role; stem; stem cell population; vascular",Role of Adenosine Receptors in Neovascularization, Narrative: The use of adult stem cells holds great promise for treatment of cardiovascular disease. The goal of this proposal is to understand the role of specific cell surface molecules called adenosine receptors in new blood vessel growth induced by stem cells. This knowledge may improve cell-based therapies.,95787,MIM,Myocardial Ischemia and Metabolism Study Section,A1,1,387500,
7785384,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095791-01A1,,NHLBI:834441;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,PEDIATRICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"KEAN, LESLIE S;",1879993;,1R01HL095791,02/01/2010,01/31/2015,"21+ years old; Acute GVHD; Acute Graft Versus Host Disease; Address; Adhesions; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Adult; Antibodies; Aplastic Anemia; Biologic Therapy; Biological Models; Biological Response Modifier Therapy; Biological Therapy; Blood (Leukemia); Blood Diseases; Blood Serum; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Canine Species; Canis familiaris; Cell Adhesion; Cellular Adhesion; Cessation of life; Childhood; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clinical, Transplantation, Organ; Death; Diagnosis; Disease; Disorder; Dogs; Donor person; Evaluation; Face; Genetic; Graft Rejection; Grafting Procedure; Grafting, Bone Marrow; Hb SS disease; HbSS disease; Hematologic Diseases; Hematological Disease; Hematological Disorder; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hereditary Metabolic Disorder; Human; Human, Adult; Human, General; IMPHENO; ITX; Immune; Immune response; Immunity; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Immunologically Directed Therapy; Immunophenotyping; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunotherapy; Immunotherapy, Adoptive; Inborn Errors of Metabolism; Intervention; Intervention Strategies; Investigation; Lead; Leukemias, General; Life; Macaca mulatta; Malignant; Malignant - descriptor; Mammals, Dogs; Mammals, Mice; Mammals, Primates; Man (Taxonomy); Man, Modern; Marrow Transplantation; Metabolism, Inborn Errors; Mice; Minority; Model System; Modeling; Models, Biologic; Murine; Mus; Natural immunosuppression; Non-Malignant; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Pathway interactions; Patients; Pb element; Phenotype; Plague; Population; Pre-Clinical Model; Preclinical Models; Preclinical Testing; Prevention; Prevention Measures; Primates; Prophylactic treatment; Prophylaxis; Protocols, Treatment; Public Health; RGM; Regimen; Registries; Regulatory T-Lymphocyte; Research Proposals; Reticuloendothelial System, Bone Marrow; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk; Serum; Siblings; Sickle Cell Anemia; Solid; Source; Subtyping, Immunologic; Subtypings, Immunologic; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Transplant Recipients; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation Surgery; Treatment Protocols; Treatment Regimen; Treatment Schedule; Yersinia pestis disease; adoptive cell immunotherapy; adult human (21+); base; biomarker; biotherapeutics; biotherapy; blood disorder; canine; clinical applicability; clinical application; clinical investigation; disease prevention; disease/disorder; disorder prevention; domestic dog; experiment; experimental research; experimental study; facial; heavy metal Pb; heavy metal lead; host response; hypoimmunity; immune deficiency disorder; immune therapy; immunodeficiency; immunophenotype; immunoresponse; immunosuppression; immunosuppressive; inborn metabolism disorder; insight; interventional strategy; leukemia; new therapeutics; next generation therapeutics; nonmalignant; novel; novel therapeutic intervention; novel therapeutics; organ allograft; organ graft; organ xenograft; pathway; pediatric; prevent; preventing; public health medicine (field); public health relevance; research study; sickle cell disease; sickle disease; sicklemia; thymus derived lymphocyte; transplant; transplant donor; transplant patient",Novel Biologic Therapies for BMT: Mechanistic Evaluation in Rhesus Macaques," Project Narrative: Bone marrow transplantation (BMT) is the treatment of choice for many of the thousands of pediatric and adult patients each year who are diagnosed with both malignant and non-malignant hematologic diseases, including leukemia, aplastic anemia, sickle cell disease, as well as the genetic immunodeficiencies and other inborn errors of metabolism. While BMT represents the best hope for cure for these devastating disorders, it is a treatment that is fraught with complications, which continue to severely limit its wide-spread application, especially for the large majority of patients (70-80%) which lack an MHC-matched sibling bone marrow donor and thus must be transplanted using an 'alternative-donor BMT' (AD-BMT): while some of these patients without a matched sibling donor will find a highly matched unrelated donor from the registry, the wait-time to activate these donors is often prohibitive (for patients with the most aggressive malignant diseases), and many minority populations still lack adequate donors in the registry, making them far less likely to find a matched unrelated donor than patients from the ethnic majority. This research proposal thus has direct relevance to world-wide public health, in that it seeks to understand the mechanisms and efficacy of new biologic therapies for AD-BMT, in order to develop safer, and more efficacious therapeutic regimens for the thousands of patients requiring this treatment each year.",95791,TTT,"Transplantation, Tolerance, and Tumor Immunology",A1,1,834441,
7783873,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095820-01A1,,NHLBI:488275;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"TSAI, AH-LIM ;",1887240;,1R01HL095820,02/01/2010,01/31/2014,"5,6,7,8-tetrahydrobiopterin; Active Oxygen; Address; Anabolism; Arginine; Arginine, L-Isomer; BH4; BPH4; Binding; Binding (Molecular Function); Body Tissues; CNOS; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiovascular Diseases; Catalysis; Causality; Cell model; Cells; Cellular model; Constitutive NOS; Coupled; Cysteine; Dehydrogenases; Dependence; Disease; Disorder; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; ENDOR; ENOS; EPR spectroscopy; Electron Nuclear Double Resonance; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Equilibrium; Etiology; Event; FMN; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Flavin Mononucleotide; Flavins; Fluorescence Microscopy; Freezing; Functional disorder; Guanylyl Cyclase-Activating Factor Synthase; H2O2; H4B; H4biopterin; Half-Cystine; Heart Diseases; Heart myocyte; Heme; Heme b; Hepatocyte Nitric Oxide Synthase; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hydroxyl; Hydroxyl Radical; Hypoxia; Hypoxic; INOS; In Vitro; Inducible Nitric Oxide Synthase; Ischemia; Ischemia-Reperfusion Injury; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Isoenzymes; Isoforms; Isotopes; Isozymes; Kinetic; Kinetics; Knowledge; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Cysteine; Length; Ligands; Macrophage Nitric Oxide Synthase; Measurement; Mercaptans; Mercapto Compounds; Methods; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular Interaction; Monitor; Mononitrogen Monoxide; Muscle Cells, Cardiac; Muscle Cells, Heart; Mutagenesis, Site-Directed; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocytes, Cardiac; NADPH-Diaphorase; NO Synthase; NOS 1 protein; NOS Type II; NOS Type III; NOS2; NOS2A; NOS2A protein, human; NOS3; NOS3 protein, human; NOSIII; Neural Constitutive Nitric Oxide Synthase; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 2A; Nitric Oxide Synthase 3; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Oxidation-Reduction; Oxidoreductase; Oxygen; Oxygen Deficiency; Oxygen Radicals; Oxygenases; Paramagnetic Resonance; Peroxonitrite; Peroxonitrites; Peroxynitrites; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic pulse; Physiology; Physiopathology; Pro-Oxidants; Process; Protein Isoforms; Proteins; Protoheme; Protoheme IX; Pulse; Reaction; Reactive Nitrogen Species; Reactive Oxygen Species; Redox; Reductases; Regimen; Regulation; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Riboflavin 5'-(dihydrogen phosphate); Riboflavin 5'-Monophosphate; Riboflavin 5'-Phosphate; Riboflavin Mononucleotide; Role; SH-Reagents; Signal Pathway; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Spectroscopy, ESR; Spin Trapping; Staging; Structure; Sulfhydryl Compounds; Sulfhydryl Reagents; Superoxide Anion; Superoxide Radical; Superoxides; THBP; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Thiol Reagents; Thiols; Tissues; balance; balance function; biosynthesis; cardiac infarct; cardiomyocyte; cardiovascular disorder; catalyst; chemical reaction; cofactor; coronary attack; coronary infarct; coronary infarction; dimer; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; eNOS enzyme; electron paramagnetic resonance spectroscopy; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; ferroheme; gene product; heart attack; heart disorder; heart infarct; heart infarction; heart ischemia; human NOS2A protein; human NOS3 protein; iNOS enzyme; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; macrophage; monomer; mutant; myocardial ischemia/hypoxia; myocardium ischemia; nNOS enzyme; neuronal nitric oxide synthase; nitric oxide synthase, Type II; oxidation; oxidation reduction reaction; pathophysiology; peroxynitrite; prevent; preventing; public health relevance; reperfusion; social role; sulfhydryl group; tetrahydro-6-biopterin; tetrahydrobiopterin",Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia Reperfusion," PROJECT NARRATIVE This project focuses on characterizing the structure and temporal dependence of the radical intermediates, including ROS and RNS, induced by oxygen in all three nitric oxide synthase isozymes. The regulation of these radical intermediates by substrate, cofactors and thiol also are studied, both in vitro and ex vivo, in order to elucidate the underlying disease mechanism of myocardial ischemia and reperfusion injury.",95820,MSFE,Macromolecular Structure and Function E Study Section,A1,1,488275,
7785275,R01,HL,1,,01/22/2010,11/30/2010,PA-07-070,1R01HL095846-01A1,,NHLBI:362500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LITTLE ROCK,UNITED STATES,PHARMACOLOGY,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"PALADE, PHILIP T. (contact);PANG, LI ;",1881782 (contact);8544285;,1R01HL095846,01/22/2010,11/30/2013,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; AAV vector; ANG-(1-8)Octapeptide; Adeno-Associated Viruses; Adverse effects; American; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; Blood Vessels; Blotting, Western; Calcium Antagonists, Exogenous; Calcium Blockaders, Exogenous; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Channel Blockers; Calcium Channel Blocking Drugs; Calcium Inhibitors, Exogenous; Cardiovascular Diseases; Cells; Chronic; Clinical; Compliance behavior; Coupled; DNA Sequence; Dependovirus; Dose; Drug usage; Drugs; Electrodes, Miniaturized; Enhancers; Epidemic; Event; Exhibits; Experimental Animal Model; Foundations; Genes; Hypertension; Hypotension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; In Vitro; Infusion; Infusion procedures; Ion Channels, Calcium; Ion Channels, Potassium; K channel; Lead; Leiomyocyte; Levarterenol; Levonorepinephrine; Mammals, Mice; Mediating; Medication; Membrane Potentials; Mesenteric; Mesenteric Arteries; Mesenteric Circulation; Mesentery; Methods; Mice; Micro RNA; MicroRNAs; Microelectrodes; Minority; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Heavy Chains; Noradrenaline; Norepinephrine; Patient Compliance; Patient Cooperation; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Potassium Channel; Pressure; Pressure- physical agent; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Receptors, Calcium Channel Blocker; Regimen; Rest; Resting Potentials; Site; Small RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Splanchnic Circulation; Technology; Testing; Therapeutic; Time; Transcript; Transmembrane Potentials; Treatment Compliance; Treatment Side Effects; VDCC; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vascular constriction (function); Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Viral; Voltage-Dependent Calcium Channels; Voltage-Gated K+ Channels; Voltage-Gated Potassium Channel; Western Blotting; Western Blottings; Western Immunoblotting; Western World; adeno associated virus group; adeno-associated viral vector; adeno-associated virus vector; base; calcium antagonist; cardiovascular disorder; cell type; channel blockers; compliance cooperation; design; designing; drug use; drug/agent; gene product; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; miRNA; mouse model; myosin heavy chain; normotensive; novel; patch clamp; patient adherence; pressure; protein blotting; public health relevance; restoration; side effect; therapy adverse effect; therapy compliance; therapy cooperation; treatment adverse effect; vascular; vasopressor",MicroRNA to decrease vascular CaV1.2 in hypertension," NARRATIVE High blood pressure known as hypertension afflicts over 60 million Americans and can lead to even more debilitating conditions. While there are numerous short-acting medications (including calcium channel blockers) to treat hypertension, most patients do not take their medications faithfully and consequently less than one third of patients have their blood pressure adequately controlled. We have developed a small RNA-based therapeutic (microRNA) which decreases expression of a calcium channel found in blood vessels that is also the site of action of all antihypertensive calcium channel blockers. When incorporated into a safe adeno associated virus, our therapeutic can continuously produce more microRNA over a period of months. In addition our therapeutic is coupled to a DNA sequence that will selectively generate the desired microRNA only in vascular smooth muscle cells that make up the wall of blood vessels. This is likely to reduce side effects encountered with many orally administered antihypertensive medications, which spread throughout the body. A longer lasting therapy with fewer side effects may be extremely beneficial for the >40 million Americans whose hypertension is not properly managed.",95846,HM,Hypertension and Microcirculation Study Section,A1,1,362500,
7792954,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL095924-01A1,,NHLBI:396458;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BROOKLYN,UNITED STATES,PEDIATRICS,11,040796328,US,NY,11203,SUNY DOWNSTATE MEDICAL CENTER,"HUSSAIN, M MAHMOOD;",1868436;,1R01HL095924,02/01/2010,01/31/2014,"6-Methylcompactin; AAT1; ALT1; Ablation; Abscission; Accounting; Adverse effects; Advocate; Agonist; Alanine Aminotransferase; Alanine Transaminase; Alanine-2-Oxoglutarate Aminotransferase; Aminotransferases; Anabolism; Apo-B; ApoB; Apolipoproteins B; Apoptosis; Apoptosis Pathway; Aspartate Aminotransferases; Aspartate Apoaminotransferase; Aspartate Transaminase; Assimilation; Assimilations; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Blood Plasma; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; Canine Species; Canis familiaris; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Catabolism; Cell Death; Cell Death, Programmed; Chaperone; Chemicals; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Esters; Cholesteryl Esters; Coronary; Data; Dehydrogenases; Diabetes Mellitus; Diet; Disease; Disorder; Dogs; Drugs; EC 2.6.1; Endoplasmic Reticulum; Enzymes; Ergastoplasm; Event; Excision; Extirpation; Familial Combined Hyperlipidemia; Familial Hypercholesterolemia; Fats; Fatty Acids; Fatty acid glycerol esters; Future; GPT; GPT1; Gene Deletion; Genes; Genetic; Glutamate-Aspartate Transaminase; Glutamic-Alanine Transaminase; Glutamic-Oxaloacetic Transaminase; Glutamic-Pyruvate Transaminase; Glutamic-Pyruvic Transaminase; Golgi; Golgi Apparatus; Golgi Complex; Grafting, Liver; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hyperbetalipoproteinemia; Hypercholesterolemia, Essential; Hypercholesterolemia, Familial; Hyperlipemia; Hyperlipidemia; Hyperlipidemia, Familial Combined; Hyperlipidemia, Multiple Lipoprotein-Type; Hyperlipoproteinemia Type 2; Hyperlipoproteinemia Type II; In Vitro; Induction of Apoptosis; Injury; Intestinal; Intestines; Investigators; Isoforms; JNK; JNK1; JNK1A2; JNK21B1/2; L-Alanine[{..}]2-oxoglutarate aminotransferase; L-Aspartate-2-Oxoglutarate Aminotransferase; L-Aspartate[{..}]2-oxoglutarate aminotransaminase; Lead; Link; Lipids; Lipoproteins; Liver; Liver Cells; Liver Transplant; Lovastatin; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MTP triglyceride carrier; Mammals, Dogs; Mammals, Mice; Measurement; Medication; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Mevinolin; Mice; Microsomes; Mixed Hyperlipidemia; Modality; Molecular; Molecular Chaperones; Monacolin K; Murine; Mus; Obesity; Olive Oil; Olive oil preparation; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; Oxidoreductase; PRKM8; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphatides; Phospholipids; Plasma; Population; Process; Production; Protein Inhibition; Protein Isoforms; Proteins; Reductases; Removal; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Risk Factors; Role; SAPK1; Serum, Plasma; Solutions; Structural Protein; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Testing; Thapsigargin; Therapeutic Intervention; Therapeutic Uses; Thesaurismosis; Toxic effect; Toxicities; Transaminases; Transplantation of liver; Transplantation, Hepatic; Treatment Side Effects; Triacylglycerol; Triglycerides; Tunicamycin; Type 2 Hyperlipidemia; Type 2b Hyperlipoproteinemia; Type II Hyperlipidemia; Type IIb Hyperlipoproteinemia; Vascular, Heart; adiposity; atheromatosis; atherosclerotic vascular disease; bariatric surgery; base; biological adaptation to stress; biosynthesis; body system, hepatic; bowel; canine; caspase 12; cholesterol biosynthesis; circulatory system; corpulence; corpulency; corpulentia; diabetes; disease/disorder; domestic dog; drug/agent; endoplasmic reticulum stress; experiment; experimental research; experimental study; familial hyperbetalipoproteinemia; familial hypercholesteremia; familial hyperlipoproteinemia type 2; familial hyperlipoproteinemia type II; fatty acid oxidation; feeding; gastric banding; gastric bypass surgery; gene deletion mutation; gene product; genetic inhibitor; glutamic aspartic transaminase; heavy metal Pb; heavy metal lead; implantable gastric stimulation banding; in vitro activity; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; intervention therapy; liver transplantation; metabolism disorder; mevacor; microsomal TG transfer protein; microsomal triglyceride transfer protein; necrocytosis; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; obese; obese people; obese person; obese population; obesity surgery; organ system, hepatic; pathway; public health relevance; reaction; crisis; research study; resection; side effect; social role; stomach stapling; stress response; stress; reaction; success; surgery; therapy adverse effect; transaminase A; treatment adverse effect; weight loss surgery",Avoiding toxicity associated with MTP ablation, Project narrative This proposal is to find out why MTP drugs cause unwanted side effects and to come up with novel solutions to avoid these effects. These studies will explain molecular mechanisms involved in toxicities associated with MTP inhibitors and genetic ablations. Proposed studies may lead to new therapeutic modalities for the treatment of various disorders associated with high plasma lipids.,95924,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,A1,1,396458,
7785160,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL096121-01A1,,NHLBI:379000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"LIEN, CHING-LING ELLEN;",7772399;,1R01HL096121,02/01/2010,01/31/2015,"21+ years old; Abscission; Adult; Adventitial Cell; Antimorphic mutation; Blood Vessels; Body Tissues; Brachydanio rerio; CD140A; CD140B; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cicatrix; Coronary; Coronary Vessels; DNA Replication; DNA Synthesis; DNA biosynthesis; Danio rerio; Defect; Degenerative Disorder; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; Embryo; Embryonic; Endothelial Cells; Epicardium; Excision; Extirpation; FLR; Failure (biologic function); Fishes; Functional disorder; Future; Goals; Healed; Heart; Heart Diseases; Heart myocyte; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Human; Human, Adult; Human, General; In Vitro; Injury; Intracellular Communication and Signaling; JTK12; Lead; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Mesenchymal; Modeling; Molecular; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardium; Myocytes, Cardiac; Natural regeneration; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organism; PDGF; PDGF-R-Beta; PDGFR; PDGFR1; PDGFR2; PDGFRA; PDGFRA gene; PDGFRB; PDGFRB gene; Pathology; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Physiopathology; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor Receptor; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Receptor Signaling; Receptors, PDGF; Regeneration; Regenerative Medicine; Removal; Research; Rouget Cells; Scars; Signal Transduction; Signal Transduction Systems; Signaling; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Testing; Therapeutic; Time; Tissues; Transgenic Organisms; United States; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); base; biological signal transduction; cardiac muscle; cardiomyocyte; cell type; degenerative condition; degenerative disease; design; designing; disability; epithelial to mesenchymal transition; failure; healing; heart disorder; heart muscle; heavy metal Pb; heavy metal lead; improved; in vivo; knock-down; living system; neovascularization; novel therapeutic intervention; pathophysiology; progenitor; public health relevance; regenerate; regenerate new tissue; regenerating damaged tissue; regenerative; resection; surgery; tissue regeneration; transgenic; vascular",Molecular Mechanisms of Zebrafish Heart Regeneration," Narrative  Regenerative medicine holds a great deal of promise for treating congenital and degenerative diseases. The goal of this proposal is to determine the molecular and cellular mechanisms of heart regeneration in zebrafish, an organism with a natural regenerative ability. We expect the proposed research can lead to findings that may enhance regenerative capacity in diseased human hearts in the future.  ",96121,CDD,Cardiovascular Differentiation and Development Study Section,A1,1,379000,
7783278,R01,HL,1,,01/29/2010,11/30/2010,PA-07-070,1R01HL096305-01A1,,NHLBI:385000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"PELUS, LOUIS M;",2064981;,1R01HL096305,01/29/2010,11/30/2014,"21+ years old; APC; Adult; Affect; Agonist; Anabolism; Antigen-Presenting Cells; Blood Precursor Cell; Blood, Cord; Bone Marrow; CSF3; CSF3 gene; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Cannabinoids, Endogenous; Cell Count; Cell Cycle; Cell Division Cycle; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Number; Cell Process; Cell Proliferation; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Collection; Complex; D2S201E; Dinoprostone; Eicosanoid Modulation; Eicosanoid Production; Eicosanoids; Endocannabinoids; Engraftment; Exposure to; FB22; Family; G-CSF; GCSF; Genetic Condition; Genetic Diseases; HM89; HSC transplantation; HSY3RR; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hereditary Disease; Homing; Human, Adult; Immunologic Accessory Cells; In Vitro; LAP3; LCR1; LESTR; Laboratories; Leukotrienes; Light; Lipids; MGC45931; Maintenance; Maintenances; Marrow; Mediating; Methods; Molecular Disease; Monitor; Monocytes / Macrophages / APC; Mother Cells; Myelopoiesis; NPY3R; NPYR; NPYRL; NPYY3R; Outcome; PBSC; PGE2; PGE2 alpha; PGE2alpha; Pathway interactions; Patients; Peripheral Blood Stem Cell; Peripheral Stem Cells; Photoradiation; Physiologic; Physiologic pulse; Physiological; Play; Progenitor Cell Engraftment; Progenitor Cell Transplantation; Progenitor Cells; Progenitor Cells, Hematopoietic; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostacyclins; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandins; Prostaglandins I; Prostanoids; Pulse; Receptor Protein; Reticuloendothelial System, Bone Marrow; Role; Signal Pathway; Source; Stem Cell Mobilization; Stem Cell Transplantation; Stem cell transplant; Stem cells; Subcellular Process; Thromboxanes; Translating; Translatings; Transplantation; Umbilical Cord Blood; Work; accessory cell; adult human (21+); biosynthesis; fetal cord blood; genetic disorder; hematopoietic stem cell fate; hematopoietic tissue; hereditary disorder; his-PG; improved; in vivo; interest; language translation; member; pathway; peripheral blood; progesterone 11-hemisuccinate-(2-iodohistamine); public health relevance; receptor; self-renewal; social role; stem; transplant",Role of PGE2 and other eicosanoids in hematopoietic stem cell function,,96305,HP,Hematopoiesis Study Section,A1,1,385000,
7799007,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL096376-01A1,,NHLBI:493005;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MALLAMPALLI, RAMA K;",1902026;,1R01HL096376,02/01/2010,01/31/2014,"APF-1; ASPR; ATP-Dependent Proteolysis Factor 1; Acute; Acute Pulmonary Injury; Adverse effects; Alveolar; Alveolar Cell; Antimorphic mutation; Apical; Apoptosis; Apoptosis Pathway; Apoptotic; Aspirate; Aspirate substance; Assay; Attenuated; Bacterial Infections; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Bronchial Lavage Fluid; Bronchioalveolar Lavage; Bronchoalveolar Lavage; COAD; COPD; Cardiolipins; Carrier Proteins; Cartoons; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chronic; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Complement; Complement Proteins; Coupled; Data; Disease; Disorder; Distal; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Douching, other than vaginal; Drugs; E coli; E3 Ligase; E3 Ubiquitin Ligase; Epithelial; Epithelial Cells; Epithelium; Escherichia coli; Escherichia coli Infections; Exhibits; Expression Profiling; Expression Signature; Foundations; Gene Transfer; Generations; HMG-20; High Mobility Protein 20; Human; Human, General; Impairment; In Vitro; Infection; Infections, E coli; Inflammation Mediators; Inflammatory; Intermediary Metabolism; Irrigation; Irrigation, other than vaginal; Knock-out; Knockout; Laboratories; Lavage; Lavage Fluids, Alveolar; Lavage, Bronchopulmonary; Lead; Left; Link; Lipids; Liquid substance; Lung; Lung Alveolar Epithelia; Lung Compliance; Lung Injury, Acute; Lung Lavage; Lung Lavage Fluid; Lung diseases; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane; Metabolic Processes; Metabolism; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Modeling; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Murine; Mus; Mutant Strains Mice; Nonvaginal irrigation; Nonvaginal lavage; Organism-Level Process; Organismal Process; P. aeruginosa; P.aeruginosa; Pathway interactions; Patients; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatides; Phosphatidylserines; Phospholipids; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Physiology; Pneumonia; Pneumonitis; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; Pump; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory physiology; Role; Sepsis; Sequence-Specific Posttranscriptional Gene Silencing; Serine Phosphoglycerides; Severity of illness; Structure; Structure of alveolar epithelium; Surface Tension; Teaching Hospitals; Testing; Time; Transgenic Mice; Transport Proteins; Transporter Protein; Treatment Side Effects; Ubiquitin; Ubiquitin-Protein Ligase E3; Universities; Ventilator; Virulent; Work; acute lung injury; alveolar epithelium; bacterial disease; base; bloodstream infection; bronchopulmonary lavage therapy; clinical relevance; clinically relevant; cultured cell line; disease severity; disease/disorder; drug/agent; fluid; gene product; heavy metal Pb; heavy metal lead; human disease; in vitro activity; in vivo; inhibitor; inhibitor/antagonist; irrigation therapy; lavage therapy; liquid; lung disorder; lung function; lung injury; member; membrane structure; microbial; mitochondrial; molecuar profile; molecular signature; mouse mutant; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; overexpression; pathogen; pathway; patient centered; patient oriented; programs; protein expression; public health relevance; pulmonary; respiratory function; response; sensor; side effect; site targeted delivery; small molecule; social role; surfactant; targeted delivery; therapy adverse effect; tool; trafficking; transfer of a gene; treatment adverse effect; ubiquitin-protein ligase; uptake",Cardiolipin Induced Lung Injury and FIC1," NARRATIVE We have recently discovered that in pneumonia, there is marked elevation of a rare lipid, termed cardiolipin, that potently inhibits lung function. We have also discovered a lipid pump, termed FIC1, that is rapidly degraded after bacterial infection. We propose in this application to use several tools to confirm that FIC1 is indispensable for controlling the availability of cardiolipin in lung fluid, to identify the molecular and biochemical mechanisms for FIC1 breakdown after bacterial infection, and to correlate cardiolipin levels in lung fluid of patients having pneumonia with illness severity.",96376,ZRG1,Special Emphasis Panel,A1,1,493005,
7791263,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL096706-01A1,,NHLBI:338834;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,PHARMACOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"TOTAH, RHEEM ANGELA;",3081253;,1R01HL096706,02/01/2010,01/31/2015,"Acids; Action Potentials; Adhesion Molecule; Adverse drug effect; Anabolism; Antibodies; Arachidonic Acids; Arrhythmia; Body Tissues; Boxing; C 1 Esterase; C1 Esterase; C1 s; C1s; CYP2J2; CYP2J2 protein, human; CYPIIJ2; Cardiac; Cardiac Arrhythmia; Cardiac Myocytes; Cardiac Toxicity; Cardiocyte; Cardiotoxicity; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Adhesion Molecules; Cell model; Cellular model; Chemicals; Chronic; Common Rat Strains; Complement 1 Esterase; Complement 1s; Complement component C1s; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Data; Drug Prescribing; Drug Prescriptions; Drug Side Effects; Drug or Chemical; Drugs; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium-Derived Relaxing Factor; Enzymes; Ethers; Food; Frequencies (time pattern); Frequency; General Population; General Public; Genes; Heart; Heart Arrhythmias; Heart myocyte; Human; Human, General; Iatrogenic Disease; Intermediary Metabolism; Ion Channel; Ion Channels, Potassium; Ionic Channels; Isoenzymes; Isozymes; K channel; Kinetic; Kinetics; Label; Laboratories; METBL; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Membrane Channels; Metabolic Processes; Metabolism; Mice; Mice, Transgenic; Microsomes; Moab, Clinical Treatment; Monoclonal Antibodies; Mononitrogen Monoxide; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocytes; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; P450; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Potassium Channel; Prescriptions, Drug; RNA, Small Interfering; Rat; Rattus; Recombinants; Reporting; Research; Research Proposals; Risk; Role; Safety; Small Interfering RNA; System; System, LOINC Axis 4; Testing; Time; Tissues; Torsades de Pointes; Toxic effect; Toxicities; Transgenic Mice; Transgenic Organisms; Vascular, Heart; Ventricular; Wild Type Mouse; Withdrawal; Xenobiotics; biosynthesis; cardiomyocyte; cell adhesion protein; circulatory system; cytochrome P450 2J2 (human); cytokine; design; designing; drug market; drug/agent; endothelial cell derived relaxing factor; improved; inhibitor; inhibitor/antagonist; prevent; preventing; public health relevance; siRNA; social role; transgenic",Role of CYP2J2 in Xenobiotic Induced QT-prolongation," Project Narrative: The research described in this proposal aims at understanding the mechanism of an iatrogenic disease. Sometimes ingesting certain drugs or chemicals in food interferes with the endogenous function of an enzyme, CYP2J2, and may precipitate cardiotoxicity. Predicting which drugs pose a risk of modulating CYP2J2 activity will aid us in preventing this cardiotoxicity before it occurs, improve drug safety, and reduce drug adverse effects.",96706,ZRG1,Special Emphasis Panel,A1,1,338834,
7793009,R01,HL,1,,01/19/2010,11/30/2010,PA-07-070,1R01HL097111-01A1,,NHLBI:395000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ALBANY,UNITED STATES,OTHER BASIC SCIENCES,21,190592162,US,NY,12208,ALBANY MEDICAL COLLEGE,"TREBAK, MOHAMED ;",8828812;,1R01HL097111,01/19/2010,11/30/2014,"1,2-diacylglycerol; Adenoviridae; Adenoviruses; Agonist; Arachidonic Acids; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biochemical; Blood Coagulation Factor IV; Blood Pressure, High; Blood Vessels; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chiro-Inositol; Clinical; Co-Immunoprecipitations; Coagulation Factor IV; Common Rat Strains; Cytoplasmic Membrane; DAG; Development; Diacylglycerols; Diglycerides; Disease; Disorder; Drug Therapy; Dysfunction; Electrophysiology; Electrophysiology (science); Ensure; FRET; Factor IV; Fluorescence Resonance Energy Transfer; Functional disorder; GOK Gene; Gene Products, RNA; GeneHomolog; Goals; Growth Factor Receptors; Homolog; Homologous Gene; Homologue; Hypertension; Image; Immigrations; In Vitro; In-Migration; Injury; Inositol; Intracellular Communication and Signaling; Intracellular Second Messengers; Ion Channel; Ion Channels, Calcium; Ionic Channels; Lecithinase C; Leiomyocyte; Mammals, Rats; Mediating; Membrane Channels; Mesoinositol; Microscopy; Modeling; Molecular; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neurophysiology / Electrophysiology; PDGF; Pathway interactions; Pharmacotherapy; Phenotype; Phospholipase C; Physiopathology; Plasma Membrane; Platelet-Derived Growth Factor; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Proliferating; Proteins; Proto-Oncogene, Growth Factor Receptor; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; Rat; Rattus; Receptor Protein; Receptors, Calcium Channel Blocker; Regulation; Ribonucleic Acid; Role; STIM1; STIM1 gene; Sarcoplasmic Reticulum; Second Messenger Systems; Second Messengers; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Stromal Interaction Molecule 1 Gene; Subcellular Process; Testing; Thrombase; Thrombin; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); VDCC; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Voltage-Dependent Calcium Channels; angiogenesis; atheromatosis; atherosclerotic vascular disease; biological signal transduction; blood vessel disorder; diacylglycerol; diglyceride; disease/disorder; fibrinogenase; gene product; hyperpiesia; hyperpiesis; hypertensive disease; imaging; in vivo; injured; insight; leiomyosarcoma; lipophosphodiesterase I; migration; novel; patch clamp; pathophysiology; pathway; phosphatidylcholine cholinephosphohydrolase; plasmalemma; protein expression; public health relevance; receptor; repair; repaired; response; second messenger; sensor; social role; vascular; vascular smooth muscle cell proliferation; voltage",Receptor-regulated Ca2+ Entry Pathways in Smooth Muscle, PROJECT NARRATIVE The results from this proposal will generate a better understanding of VSMC physiology and unveil novel targets for drug therapy aimed at controlling VSMC proliferation and migration that occur during vascular diseases such as atherosclerosis and hypertension.,97111,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",A1,1,395000,
7790726,R01,HL,1,,01/15/2010,11/30/2010,PA-07-070,1R01HL097365-01A1,,NHLBI:415000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,PATHOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"BORNFELDT, KARIN E.;",2319037;,1R01HL097365,01/15/2010,11/30/2013,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 60B8-B Antigen; AGE receptor; Address; Antigen 60B8-A; Arterial Fatty Streak; Arteries; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoimmune; Autoimmune Process; Binding; Binding (Molecular Function); Bleeding; Blood monocyte; Body Tissues; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; CABP-P14; CABP-P8; CAGA; CAGB; CGCB; CGLA; CGLB; Calgranulin A; Calgranulin B; Calprotectin L1H Subunit; Calprotectin L1L Subunit; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cause of Death; Complement; Complement Proteins; Coronary Occlusions; Cystic Fibrosis Antigen; Cytofluorometry, Flow; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetic Angiopathies; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Diabetic mouse; Electromagnetic, Laser; Employee Strikes; Equilibrium; Event; Exhibits; Figs; Figs - dietary; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Germany; Goals; Grafting, Bone Marrow; Greater sac of peritoneum; Hemorrhage; Human; Human, General; IDD; IDDM; INFLM; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Insulin-Dependent Diabetes Mellitus; Knock-out; Knockout; LIAG; Lasers; Lesion; Leukocyte L1 Complex Heavy Chain; Leukocyte L1 Complex Light Chain; Leukocyte L1 Protein Heavy Chain; Leukocyte L1 Protein Light Chain; Lipoprotein LDL Receptors; Liver; Low Density Lipoprotein Receptor; MA387; MAC387; MRP-14 Protein; MRP-8 Protein; MRP14; MRP14 Protein; MRP8; MRP8 Protein; Macrophage Activation; Macrophage-Related Protein-14; Macrophage-Related Protein-8; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Marrow monocyte; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Transgenic; Microfluorometry, Flow; Migration Inhibitory Factor-Related Protein 14; Migration Inhibitory Factor-Related Protein 8; Modeling; Molecular; Molecular Interaction; Morphology; Murine; Mus; Myeloid Calcium-Binding Protein P8; Myeloid Calcium-Binding Protein p14; Occlusions, Coronary; Organ System, Cardiovascular; Pathogenesis; Pathway interactions; Patients; Peritoneal; Peritoneal Cavity; Photometry/Spectrum Analysis, Mass; Play; Population; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteome; Proteomics; Protocol; Protocols documentation; RAGE receptor; Radiation, Laser; Receptors, LDL; Recombinants; Regulation; Relative; Relative (related person); Research; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Spleen; Role; S100 A8 Protein; S100 Calcium Binding Protein A8; S100 Calcium Binding Protein A9; S100A8; S100A8 Protein; S100A8 gene; S100A9; S100A9 Protein; S100A9 gene; STZ; Scheme; Sclerosis; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spleen; Streaks, Arterial Fatty; Streptozocin; Streptozotocin; Strikes; Strikes, Employee; T1 diabetes; T1D; T1DM; TLR4 receptor; Testing; Thick; Thickness; Tissues; Toll-4 receptor; Toxin; Transgenic Mice; Transgenic Organisms; Type 1 diabetes; Universities; Vascular, Heart; Virus; Viruses, General; Work; Zanosar; advanced glycosylation end-product receptor; amphoterin receptor; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; balance; balance function; base; biomarker; blood loss; body system, hepatic; cardiac occlusion; cardiovascular disease risk; cardiovascular disorder risk; cell type; circulatory system; cytokine; diabetes; diabetic; experiment; experimental research; experimental study; flow cytophotometry; gene product; heart occlusion; immunoreactivity; in vivo; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; laser capture microdissection; mRNA Expression; macrophage; microvascular complications; microvascular complications of diabetes; microvascular disease; monocyte; mouse model; mouse model of diabetes; non-diabetic; nondiabetic; novel; organ system, hepatic; pathway; prevent; preventing; public health relevance; receptor for advanced glycation endproducts; research study; social role; toll-like receptor 4; transgenic; treatment strategy; type I diabetes; type I diabetic; vulnerable plaque",S100A9 and S100A8 in Diabetes and Atherosclerosis, Project Narrative These studies will increase our understanding of the molecular and cellular mechanisms involved in type 1 diabetes-accelerated atherosclerotic lesion initiation and progression to advanced lesions. Identification of such mechanisms might help develop treatment strategies to target cardiovascular complications associated with type 1 diabetes.,97365,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,A1,1,415000,
7808388,R01,HL,1,,01/07/2010,12/31/2010,PA-07-070,1R01HL097561-01A1,,NHLBI:385000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,PEDIATRICS,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LIN, SHUO ;SAKAMOTO, KATHLEEN MIHO (contact);",1864456;1875087 (contact);,1R01HL097561,01/07/2010,12/31/2014,"21+ years old; 40S Ribosomal Protein S19; Adult; Apoptosis; Apoptosis Pathway; Automobile Driving; Biological Models; Birth Defects; Blood; Bone marrow failure; Brachydanio rerio; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell model; Cells; Cellular model; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DBA; Danio rerio; Data; Defect; Development; Diamond-Blackfan anemia; Disease; Disorder; Drivings, Automobile; Drugs; Dysfunction; Embryo; Embryonic; Erythrocyte Aplasia; Erythroid; FDA approved; Family; Family member; Folliculostatin; Functional disorder; Genes, p53; Genetic Alteration; Genetic Change; Genetic Diseases, Inborn; Genetic Models; Genetic defect; Hematopoiesis; Hematopoietic; Hematopoietic Cell Tumor; Hematopoietic Cellular Control Mechanisms; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Human; Human, Adult; Human, General; In Vitro; Inborn Genetic Diseases; Incidence; Inherited disorder; Inhibin Hormone; Intracellular Communication and Signaling; Lead; Libraries; Link; Malignant; Malignant - descriptor; Malignant Hematopoietic Neoplasm; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Mice; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular; Molecular Genetic Abnormality; Mother Cells; Murine; Mus; Mutation; Neonatal; P53; Pancytopenia; Pathogenesis; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiopathology; Post-Translational Regulation; Posttranslational Regulation; Pressure; Pressure- physical agent; Progenitor Cells; Protein Deficiency; Protein Subunits; Proteins; Public Health; Publishing; Pure Red-Cell Aplasia; QOL; Quality of life; RPS19; RPS19 gene; Red-Cell Aplasia, Pure; Regulation; Reticuloendothelial System, Blood; Ribosomal Proteins; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Syndrome; TP53; TP53 gene; TRP53; Testing; Therapeutic; Tumor Protein p53 Gene; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); base; biological signal transduction; blood cancer; cancer risk; clinical phenotype; disease/disorder; driving; drug/agent; exhaustion; fetal; gene product; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; inborn error; inhibin; insight; malignancy; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; p53 Signaling Pathway; pathophysiology; pathway; pressure; progenitor; public health medicine (field); public health relevance; ribosomal protein S19; social role",Molecular Pathogenesis of Diamond Blackfan Anemia," Project Narrative  This project is relevant to public health because it focuses on identifying new pathways and development of new approaches to treat DBA. Therefore, results from this work will improve the quality of life of DBA patients.",97561,ZRG1,Special Emphasis Panel,A1,1,385000,
7760749,R01,HL,1,,02/01/2010,01/31/2011,PAR-07-426,1R01HL098046-01,,NHLBI:410000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ABRAHAM, THEODORE P;",7044438;,1R01HL098046,02/01/2010,01/31/2012,"Address; Adverse Experience; Adverse event; Analysis, Data; Angiogram; Angiography; Architecture; Arrhythmia; Asia; Atrial; Atrial Fibrillation; Auricle of Heart; Auricular Fibrillation; Body Tissues; Cardiac; Cardiac Arrhythmia; Cardiac Atrium; Cardiomyopathy, Hypertrophic Obstructive; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cessation of life; Clinical; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Collection; Communities; Coronary; Custom; Data; Data Analyses; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Death; Death, Sudden; Death, Sudden, Cardiac; Development; Diagnosis; Diagnostic; Dimensions; Disease; Disease Progression; Disorder; Dysfunction; ECG; EFRAC; EKG; Echocardiography, 2-D; Echocardiography, 2D; Echocardiography, Color Flow; Echocardiography, Doppler, Color; Echocardiography, Two-Dimensional; Ejection Fraction; Electrocardiogram; Electrocardiography; Electrophysiology; Electrophysiology (science); Engineering / Architecture; Europe; Evaluation; Fainting; Functional disorder; Genetic; Genetic Condition; Genetic Diseases; Genetic Heterogeneity; Genotype; Goals; HIPAA; Health Insurance Portability and Accountability Act; Heart Arrhythmias; Heart Atrium; Heart failure; Hereditary; Hereditary Disease; History; Holter Electrocardiography; Holtmon; Hour; Hypertrophic Cardiomyopathy; Image; Individual; Informatics; Infrastructure; Inherited; Institution; Intracellular Communication and Signaling; Investigators; Kennedy Kassebaum Act; Laboratories; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Manuals; Maps; Measures; Mechanics; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Inspection; Methods; Molecular Disease; Monitoring, Holter; Morphology; Myocardial; NMR Imaging; NMR Tomography; Neurophysiology / Electrophysiology; Nuclear Magnetic Resonance Imaging; Ontology; Organ System, Cardiovascular; Outcome; Output; PL 104-191; PL104-191; Patients; Persons; Phase; Physical Examination; Physiopathology; Population; Population Research; Process; Programs (PT); Programs [Publication Type]; Public Law 104-191; Recording of previous events; Registries; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Series; Services; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Sudden Death; Syncope; System; System, LOINC Axis 4; Testing; Thick; Thickness; Time; Time Series Analysis; Tissues; Translations; Two-Dimensional Echocardiography; United States; United States Health Insurance Portability and Accountability Act; Universities; Vascular, Heart; Ventricular; Width; Work; Zeugmatography; atrium; biological signal transduction; cardiac failure; cardiac motion; cardiac scanning; cardiovascular disorder; circulatory system; clinical data repository; clinical data warehouse; clinical relevance; clinical test; clinically relevant; cluster computing; cohort; computational grid; data grid; data modeling; data repository; datagrid; design; designing; disease/disorder; distributed computing; e-science; effective therapy; escience; federated computing; federated data; federated database; genetic disorder; grid computing; heart imaging; heart motion; heart scanning; hereditary disorder; hypertrophic myocardiopathy; imaging; improved; indexing; novel; pathophysiology; patient population; prevent; preventing; programs; public health relevance; relational database; research clinical testing; sharing data; social role; tool",Development of a Hypertrophic Cardiomyopathy Consortium," Narrative This project seeks to develop a clinical consortium of hypertrophic cardiomyopathy using the cardiovascular research grid with several participating centers from the United States, Europe and Asia. This consortium, a first of its kind, would allow pooling of clinical and imaging information thus creating a large database capable of answering critical clinical questions concerning the management of hypertrophic cardiomyopathy, a common genetic disorder, not otherwise possible with smaller, single institution volumes.",98046,ZRG1,Special Emphasis Panel,,1,410000,
7753439,R01,HL,1,,01/04/2010,12/31/2010,PA-07-070,1R01HL098135-01,,NHLBI:367500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AUGUSTA,UNITED STATES,PHYSIOLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"INSCHO, EDWARD W.;",1887602;,1R01HL098135,01/04/2010,12/31/2014,"Active Oxygen; Acute; Address; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arterioles; Attenuated; Autoregulation; Behavior; Blood Pressure, High; Bone-Derived Transforming Growth Factor; CCL2; CCL2 gene; CCR2 receptor; Calcium Ion Signaling; Calcium Signaling; Cell Communication and Signaling; Cell Signaling; Chronic; Common Rat Strains; Data; Development; Dysfunction; Event; Exposure to; Functional disorder; GDCF-2; GDCF-2 HC11; Glomerular Capillary; H2O2; HC11; Homeostasis; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypertension; INFLM; Impairment; Inflammation; Inflammation Mediators; Inflammatory; Injury; Intracellular Communication and Signaling; Kidney; Left; Link; MCAF; MCP-1; MCP1; MGC9434; MMF; Mammals, Rats; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Milk Growth Factor; Muscle, Smooth, Vascular; Mycophenolate Mofetil (Cellcept); Oxygen Radicals; P2X; P2X-receptor; Pentosan Polysulfate; Physiological Homeostasis; Physiopathology; Platelet Transforming Growth Factor; Play; Polysulfate, Pentosan; Pressure; Pressure- physical agent; Pro-Oxidants; Process; Production; Property; Property, LOINC Axis 2; Rat; Rattus; Reactive Oxygen Species; Receptor Activation; Receptor Protein; Receptor Signaling; Renal Vascular; Renal function; Renal vessels; Research; Risk Factors; Role; SCYA2; SMC-CF; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Structure of arteriole; Superoxide Anion; Superoxide Radical; Superoxides; TGF B; TGF-beta; TGFbeta; Testing; Transforming Growth Factor beta; Transmission; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular constriction (function); Vascular structure of kidney; Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Work; Xylan Hydrogen Sulfate; Xylan Polysulfate; adenosine receptor activation; arteriole; biological signal transduction; cytokine; experiment; experimental research; experimental study; hyperpiesia; hyperpiesis; hypertensive disease; improved; insight; kidney function; kidney vascular; kidney vascular structure; monocyte chemoattractant protein 1 receptor; mycophenolate mofetil; mycophenolic acid morpholinoethyl ester; normotensive; pathophysiology; pressure; prevent; preventing; public health relevance; receptor; receptor, MCP-1; renal; renovascular; research study; response; social role; transmission process; vasopressor","The Inflammatory Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory Impa", Relevance: This project focuses on determining the mechanisms involved in the autoregulatory and renal microvascular dysfunction that occurs in Ang II hypertension. Our preliminary work suggests a strong link to inflammation and inflammatory mediators playing a causal role in this renal vascular impairment. Understanding the impact of hypertension and inflammation on renal vascular function will provide unique insights capable of reducing hypertensive kidney injury.,98135,HM,Hypertension and Microcirculation Study Section,,1,367500,
7763986,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL098174-01,,NHLBI:340875;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MALLAMPALLI, RAMA K;",1902026;,1R01HL098174,02/01/2010,01/31/2015,"APF-1; ATP-Dependent Proteolysis Factor 1; ATP-protein phosphotransferase; Acute; Acute Pulmonary Injury; Address; Alveolar; Animal Model; Animal Models and Related Studies; Animals; Arts; Bacteria; Bacterial Infections; Binding; Binding (Molecular Function); Biochemical; Blood Coagulation Factor IV; Ca++ element; Ca2+-Activated Protease; Calcium; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Activator Protein; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calcium-Dependent Regulator; Calmodulin; Calpain; Cardiorespiratory distress syndrome of newborn; Cartoons; Cell membrane; Cells; Choline Glycerophospholipids; Choline Phosphoglycerides; Clinical Trials; Clinical Trials, Unspecified; Coagulation Factor IV; Complex; Congenital alveolar dysplasia; Cytidyl Transferase; Cytidylyltransferase; Cytoplasmic Membrane; Data; Degradation Pathway; Degradative Pathway; Desminase; Disease; Disorder; Docking; Drugs; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Effectiveness; Enzymes; Epithelial Cells; Esteroproteases; Event; Exhibits; Expression Profiling; Expression Signature; F Box; F Box Domain; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; Factor IV; Foundations; GSK-3; Gene Transfer; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Goals; HMG-20; High Mobility Protein 20; IRDS of newborn; Idiopathic respiratory distress syndrome; Idiopathic respiratory distress syndrome of newborn; Impairment; In Vitro; Infection; Inflammatory; Intermediary Metabolism; Kinases; L-Lysine; Laboratories; Lead; Lecithin; Left; Life; Ligase; Lipids; Lung; Lung Alveolar Epithelia; Lung Injury, Acute; Lysine; METBL; Mammals, Mice; Mediating; Medication; Membrane; Messenger RNA; Metabolic Processes; Metabolism; Mice; Modeling; Modification; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monoubiquitination; Murine; Mus; NLS Peptide; Neonatal Respiratory Distress Syndrome; Newborn RDS; Newborn Respiratory Distress Syndrome; Nuclear Localization Signal; Nuclear Localization Signal Peptide; P. aeruginosa; P.aeruginosa; Papain-Like Cysteine Protease; Pb element; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphatides; Phosphatidylcholines; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phospholipids; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Plasma Membrane; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Production; Proteases; Protein Binding; Protein Kinase; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteinases; Proteins; Proteolytic Enzymes; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Pulmonary hypoperfusion syndrome of newborn; RDS, type I; RNA, Messenger; Regulation; Regulatory Protein; Replacement Therapy; Resistance; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome, Perinatal; Respiratory System, Lung; Respiratory physiology; Sepsis; Site; Stress; Structure; Structure of alveolar epithelium; Surface; Surfactant deficiency syndrome neonatal; Synthetases; Testing; Transphosphorylases; Type II Cell; Type II Epithelial Receptor Cell; Ubiquitilation; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Virulent; Wet lung disease of newborn; acute lung injury; alveolar epithelium; alveolar homeostasis; bacterial disease; bloodstream infection; clinical investigation; disease/disorder; distress; respiratory, newborn; drug/agent; enzyme activity; gene product; genetic regulatory protein; glycogen synthase a kinase; gsk-3 Gene Product; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; idiopathic respiratory distress of newborn; in vitro activity; in vivo; inhibitor; inhibitor/antagonist; lung function; lung injury; mRNA; membrane structure; model organism; molecuar profile; molecular signature; molecular site; mutant; neonatal RDS; novel; phosphorylase b kinase kinase; plasmalemma; public health relevance; pulmonary; regulatory gene product; resistant; respiratory distress syndrome; respiratory function; response; sensor; septic; small molecule; surfactant; surfactant deficiency; synthetic enzyme; tool; transfer of a gene; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",Septic Lung Injury and Surfactant," Project Narrative Sepsis-induced acute lung injury results in decreased production of surfactant, an essential material that stabilizes lung function. We have discovered that in animal models of septic lung injury, there are two mechanisms that greatly reduce function of a key surfactant synthetic enzyme, CCT: i) CCT phosphorylation by stress kinase, and ii) CCT is degraded a F-Box E 3 ligase; these effects are opposed by calmodulin. In this application we will use several tools to confirm that stress kinase and F-Box are critical factors that reduce CCT availability and surfactant production after bacterial infection. Execution of studies outlined in this application will provide a major advance in the conceptual framework for how sepsis causes lung impairment by altering surfactant production.",98174,SAT,"Surgery, Anesthesiology and Trauma Study Section",,1,340875,
7765764,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL098220-01,,NHLBI:635429;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,ANESTHESIOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"NIKLASON, LAURA E;",1873979;,1R01HL098220,01/15/2010,12/31/2013,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 21+ years old; 3-D structure; 3-dimensional structure; 3D structure; ATRA; Accounting; Address; Adhesions; Adhesives; Adult; Air; All-trans retinoic acid; Alveolar; Alveolus; American Lung Association; Anatomic; Anatomical Sciences; Anatomy; Architecture; Area; Aspiration, Respiratory; Autologous; Bears; Biology; Biomimetics; Bioreactors; Bladder; Blood; Blood Circulation; Blood Vessels; Bloodstream; Body Tissues; Bone Marrow; Breathing; Bronchi; Bronchial Alveolus; CO2; COAD; COPD; Cancer of Lung; Carbon Dioxide; Carbonic Anhydride; Cartilage; Cartilagenous Tissue; Cell Differentiation; Cell Differentiation process; Cell Therapy; Cells; Cellular Expansion; Cellular Growth; Cessation of life; Characteristics; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Chronic lung disease; Circulation; Clinical; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Complex; Connective Tissue; Data; Death; Detergents; Differentiation and Growth; ES cell; Effectiveness; Elements; Endothelium; Engineering; Engineering / Architecture; Engineerings; Environment; Epithelial; Epithelial Cells; Epithelium; Event; Exposure to; FGF-2; FGF2; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Future; Gases; Generalized Growth; Glean; Goals; Grafting, Lung; Growth; Growth and Development; Growth and Development function; HBGF-2; Harvest; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Human; Human, Adult; Human, General; In Vitro; Infection; Inhalation; Inhaling; Inspiration, Respiratory; Intervention; Intervention Strategies; Investigators; Knowledge; Liquid substance; Location; Lung; Lung Parenchyma; Lung Tissue; Lung Transplantation; Lung diseases; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Mechanics; Microscopic; Mimetics, Biological; Mission; Mortality; Mortality Vital Statistics; Mother Cells; Mucous body substance; Mucus; Natural regeneration; Neonatal; Nutrient; O element; O2 element; Organ; Oxygen; Pathologist; Patients; Perfusion; Permeability; Physiologic; Physiological; Population; Pressure; Pressure- physical agent; Procedures; Production; Progenitor Cells; Property; Property, LOINC Axis 2; Prostate Epithelial Cell Growth Factor; Prostatropin; Pulmonary Cancer; Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; Pulmonary malignant Neoplasm; Rat; Rattus; Regeneration; Regenerative Medicine; Research Personnel; Researchers; Resected; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Retinoic Acid; Rodent Model; Science of Anatomy; Skin; Social Support System; Source; Staging; Stem cells; Sterility; Structure of parenchyma of lung; Support System; Surface; System; System, LOINC Axis 4; Technology; Testing; Therapy, Cell; Tissue Engineering; Tissue Growth; Tissues; Trachea; Trachea Proper; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Universities; Urinary System, Bladder; Ursidae; Ursidae Family; Vascular Graft; Vascular Permeabilities; Vitamin A Acid; Work; adult human (21+); all-trans-Retinoic Acid; all-trans-Vitamin A acid; anatomy; bFGF; base; cell growth; cell-based therapy; clinical investigation; embryonic stem cell; engineered tissue; engineered vascular tissue; fluid; improved; in utero; in vivo; induced pluripotent stem cell; insight; inspiration; interventional strategy; liquid; lung cancer; lung disorder; lung injury; mucous; novel; ontogeny; pressure; public health relevance; pulmonary; regenerate; regenerate new tissue; regenerating damaged tissue; remediation; repair; repaired; scaffold; scaffolding; shear stress; skills; stem cell biology; stem cell of embryonic origin; sterile; success; surfactant; three dimensional structure; tissue regeneration; trans-Retinoic Acid; urinary bladder; vascular; vascular tissue engineering; windpipe",Lung Tissue Engineering,"  Lung diseases, including lung cancer and chronic lung diseases such as chronic obstructive pulmonary disease, together account for some 280,000 deaths annually. Over the past 3 years, we have worked to address some fundamental challenges in lung tissue engineering in order to provide lung tissue replacements for patients with lung disease. We hypothesize that an acellular lung matrix, when suitably re-populated with lung epithelium and vascular cells, will support the growth and differentiation of these cells and will produce a tissue that is effective for functional gas exchange.",98220,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,1,635429,
7765762,R01,HL,1,,01/19/2010,12/31/2010,PA-07-070,1R01HL098228-01,,NHLBI:413750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,SURGERY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"BREUER, CHRISTOPHER KANE;",8192044;,1R01HL098228,01/19/2010,12/31/2014,"0-11 years old; 0-6 weeks old; Absence of interventricular septum; Affect; Autologous; Biological; Birth Defects; Blood Circulation; Blood Serum; Blood Vessels; Blood monocyte; Bloodstream; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Cardiac; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cause of Death; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chemotaxis; Child; Child Youth; Children (0-21); Circulation; Clinical; Clinical Trials; Clinical Trials, Unspecified; Common Ventricle; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Constriction, Pathologic; Constriction, Pathological; Cor triloculare biatriatum; Cytokines, Chemotactic; Data; Development; Endothelial Cells; Exhibits; FLR; Failure (biologic function); Fontan Operation; Fontan Procedure; Generalized Growth; Generations; Genetic; Growth; HBGF; Homologous Chemotactic Cytokines; Human; Human, Child; Human, General; Hyperplasia; Hyperplastic; Implant; Incidence; Incubated; Individual; Infant; Infant, Newborn; Inferior vena cava structure; Intercrines; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Knock-out; Knockout; Leiomyocyte; Life; MTGN; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Medial; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Mice, Transgenic; Mitogenesis; Mitogens; Modeling; Molecular; Molecular Genetic Abnormality; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Mononuclear; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Murine; Mus; Myocytes, Smooth Muscle; Newborn Infant; Newborns; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PDGF; PDGF, B Chain; PDGF-2; PDGFB; Pathologic Processes; Pathological Processes; Pilot Projects; Platelet Derived Growth Factor Beta Chain; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor B; Platelet-Derived Growth Factor Beta; Platelet-Derived Growth Factor, B Chain; Platelet-Derived Growth Factor, Beta Polypeptide; Play; Positive Control of Cell Proliferation; Post-Operative; Postoperative; Postoperative Period; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proto-Oncogene Products c-sis; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pulmonary artery structure; Reconstructive Surgical Procedures; Recruitment Activity; Research; Reticuloendothelial System, Bone Marrow; Role; SIS Gene Product; SIS cytokines; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A2; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Source; Stenosis; Stimulation of Cell Proliferation; Surface; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Technology; Testing; Thrombosis; Tissue Engineering; Tissue Growth; Transgenic Mice; Tubular; Tubular formation; VEGFs; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vascular Graft; Vasculotropin; Vegf; Vena Cava, Inferior; Work; base; biological signal transduction; c-sis Proteins; cell motility; cellular targeting; chemoattractant cytokine; chemokine; children; clinical investigation; design; designing; effective therapy; engineered tissue; failure; graft failure; heart surgery; implantation; improved; infant outcome; interest; interventional strategy; macrophage; monocyte; mouse model; newborn human (0-6 weeks); ontogeny; paracrine; pilot study; preclinical study; public health relevance; reconstructive surgery; recruit; repair; repaired; scaffold; scaffolding; single functional ventricle; single ventricle; sis Proto-Oncogene Proteins; social role; surgery; tool; univentricular heart; vascular; youngster",Investigating the Mechanisms of Vascular Neotissue Formation In Tissue Engineered,"  Congenital cardiac anomalies are the most common birth defect and a leading cause of death in the newborn period. The most effective treatment for congenital cardiac anomalies is reconstructive surgery. Unfortunately, complications arising from the use of currently available vascular conduits are a significant cause of postoperative morbidity and mortality. The development of a tissue engineered vascular graft, created from an individual's own cells, with the ability to grow, repair, and remodel, holds great promise for advancing the field of congenital heart surgery and improving the outcomes of infants requiring surgical intervention.",98228,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,1,413750,
7765403,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL098243-01,,NHLBI:376250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,PHARMACOLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"NELSON, MARK T;",1866940;,1R01HL098243,01/15/2010,12/31/2014,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Apamin; Arterioles; Astrocytes; Astrocytus; Astroglia; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; BK channels; Big K channels; Biosensor; Blood - brain barrier anatomy; Blood Coagulation Factor IV; Blood Pressure, High; Blood Vessels; Blood flow; Blood-Brain Barrier; Brain; CNOS; Ca++ element; Calcium; Caliber; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Cerebrovascular Circulation; Cerebrum; Chiro-Inositol; Coagulation Factor IV; Communicating Junction; Communication; Complex; Constitutive NOS; Coupling; Cytoplasmic Membrane; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diameter; Disease; Disorder; Dysfunction; ECNOS; ENOS; Encephalon; Encephalons; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium, Vascular; Factor IV; Figs; Figs - dietary; Fluo 4; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Functional disorder; Gap Junctions; Genetic; Hemato-Encephalic Barrier; Hypertension; Inositol; Intracellular Communication and Signaling; Ion Channels, Potassium; K channel; K element; Leiomyocyte; Level of Evidence; Low-resistance Junction; Mammals, Mice; MaxiK channels; Measurement; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane Potentials; Mesoinositol; Mice; Mice, Transgenic; Microscopy; Modality; Murine; Mus; Muscle Tonus; Muscle, Involuntary; Muscle, Smooth; Myocytes, Smooth Muscle; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Nexus; Nexus Junction; Nitric Oxide Synthase 3; Pathway interactions; Physiopathology; Plasma Membrane; Plastics; Potassium; Potassium Channel; Primary Senile Degenerative Dementia; Property; Property, LOINC Axis 2; Pulsar; Receptor Protein; Resting Potentials; Role; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Structure of arteriole; Testing; Therapeutic Agents; Transgenic Mice; Transmembrane Potentials; Transmission; Vanilloid; Vascular Endothelial Cell; Vascular Endothelium; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vibrissae; Whiskers; Work; arteriole; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; cerebral blood flow; cerebral circulation; cerebrocirculation; dementia of the Alzheimer type; disease/disorder; eNOS enzyme; endothelial constitutive nitric oxide synthase; extracellular; fluorescent dye/probe; human NOS3 protein; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; insight; large-conductance calcium-activated potassium channels; maxi-K channels; mouse model; muscle tone; nervous system disorder; neurological disease; neuronal; neurovascular unit; new approaches; novel; novel approaches; novel strategies; novel strategy; pathophysiology; pathway; plasmalemma; primary degenerative dementia; public health relevance; receptor; response; senile dementia of the Alzheimer type; sensor (biological); slowpoke protein; social role; transmission process; two-photon; vascular","Endothelial KCa channels, Ca2+ signaling & arteriolar function in the brain"," Relevance The cells (endothelial) that line the small blood vessels (arterioles) in the brain are critical mediators of normal cerebral function, serving as both a physical barrier and a modulator of blood flow. Endothelial cell dysfunction is a common feature of blood vessel diseases (hypertension, atherosclerosis) and a likely contributor to neurological disorders (Alzheimer's). This project will elucidate key control mechanisms by which endothelial cells in cerebral arterioles regulate blood flow in the brain.",98243,HM,Hypertension and Microcirculation Study Section,,1,376250,
7765241,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL098252-01,,NHLBI:774867;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,ENGINEERING (ALL TYPES),05,097394084,US,GA,303320420,GEORGIA INSTITUTE OF TECHNOLOGY,"YOGANATHAN, AJIT P;",1966406;,1R01HL098252,02/01/2010,01/31/2014,"0-11 years old; Absence of interventricular septum; Active Follow-up; Anatomic; Anatomical Sciences; Anatomy; Arrhythmia; Arteriovenous Angioma; Arteriovenous Hemangioma; Arteriovenous malformation; Atrial; Auricle of Heart; Automobile Driving; Award; Biomedical Engineering; Birth; Blood Circulation; Bloodstream; Cardiac; Cardiac Abnormalities; Cardiac Arrhythmia; Cardiac Atrium; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac Output; Cardiac defect; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Case Report Form; CaseReportForm; Child; Child Youth; Childhood; Children (0-21); Chronic; Circulation; Clinical; Clinical Management; Clinical Markers; Cohort Analyses; Cohort Analysis; Collection; Common Ventricle; Complement; Complement Proteins; Complex; Congenital Heart Defects; Cor triloculare biatriatum; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dependence; Deterioration; Development; Diagnosis; Disease Frequency Surveys; Drivings, Automobile; Early Diagnosis; Enrollment; Enteropathy, Exudative; Environment; Equipment and supply inventories; Evaluation; Evolution; Exercise; Exercise Test; Exercise stress test; Exercise, Physical; FLR; Failure (biologic function); Figs; Figs - dietary; Forecast of outcome; Future; Generalized Growth; Grant; Growth; Heart Abnormalities; Heart Arrhythmias; Heart Atrium; Heart Defects, Congenital; Heart Malformation; Heart failure; Hepatic; Hospitals, Pediatric; Human, Child; Image; Incidence; Interdisciplinary Research; Interdisciplinary Study; Inventory; Investigation; Investigators; Lead; Longitudinal Studies; Lung; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measures; Mechanics; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Records; Metabolic; Metric; Modeling; Multidisciplinary Collaboration; Multidisciplinary Research; Myocardial depression; Myocardial dysfunction; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; Output; Parturition; Patients; Pb element; Pediatric Hospitals; Performance; Philadelphia; Physiology; Prognosis; Protein-Losing Enteropathies; Protocol; Protocols documentation; Pulmonary Artery; Pulmonary Circulation; Pulmonary Vascular Resistance; Pulmonary artery structure; Pump; QOL; Quality of life; Questionnaires; Racemose Angioma; Racemose Hemangioma; Records; Recruitment Activity; Research; Research Personnel; Researchers; Resistance; Respiratory Circulation; Respiratory System, Lung; Rest; Role; Sample Size; Science of Anatomy; Series; Study, Interdisciplinary; Surgical; Surgical Interventions; Surgical Procedure; Testing; Time; Tissue Growth; United States National Institutes of Health; Vascular Resistance, Pulmonary; Vascular, Heart; Venous; Ventricular; Ventricular Dysfunction; Ventricular Function; Work; Work Load; Workload; Zeugmatography; analytical tool; anatomy; atrium; bioengineering; bioengineering/biomedical engineering; cardiac failure; cardiovascular function; children; circulatory system; clinical data repository; clinical data warehouse; cohort; data repository; design; designing; driving; early detection; enroll; experience; failure; follow-up; heart defect; heart output; heavy metal Pb; heavy metal lead; hemodynamics; imaging; improved; in vivo; indexing; interest; long-term study; longitudinal analysis; meetings; multidisciplinary; novel; ontogeny; outcome forecast; palliative; patient population; pediatric; prevent; preventing; public health relevance; pulmonary; recruit; relational database; repair; repaired; resistant; single functional ventricle; single ventricle; social role; surgery; univentricular heart; youngster",Understanding mechanisms of Fontan failure and key predictors for patient outcome, PROJECT NARRATIVE This grant investigates the relationship between Fontan hemodynamics and ventricular function in patients born with single-ventricle heart defects. These surrogates will subsequently be correlated to quality of life measures to identify the strongest outcome predictors to be used for patient diagnosis. Understanding these interconnections will provide the means to develop optimal medical strategies to improve those outcomes.,98252,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,1,774867,
7765657,R01,HL,1,,01/01/2010,11/30/2010,PA-07-070,1R01HL098256-01,,NHLBI:375191;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,TUCSON,UNITED STATES,PHYSIOLOGY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"KONHILAS, JOHN P;",2112063;,1R01HL098256,01/01/2010,11/30/2014,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 5'-AMP-activated protein kinase; 5'-Adenylic acid; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; ATP phosphohydrolase; ATPase; Accounting; Actin Filaments; Address; Adenosine Monophosphate; Adenosine Triphosphatase; Adenosinetriphosphatase; Adenylic Acid; Blood Pressure, High; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cardiomyopathy, Hypertrophic Obstructive; Cardiovascular Diseases; Causality; Cell Communication and Signaling; Cell Signaling; Contractile Proteins; Data; Deterioration; Disease; Disease Progression; Disorder; Dysfunction; EC 2.7; Etiology; Female; Foundations; Functional disorder; Future; Genetic Alteration; Genetic Change; Genetic defect; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; HTRPY; Heart; Heart Diseases; Human; Human, General; Hypertension; Hypertrophic Cardiomyopathy; Hypertrophy; Intracellular Communication and Signaling; Isoforms; Kinases; Kinetic; Kinetics; Left; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Mice; Microfilaments; Motor; Murine; Mus; Muscle; Muscle Tissue; Muscle, Cardiac; Muscle, Heart; Mutation; Myocardial Infarct; Myocardial Infarction; Myocardium; Myofilaments; Myosin Heavy Chains; Pathology; Pathway interactions; Phosphorylation; Phosphotransferases; Physiopathology; Population; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Preparation; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Research; Role; Sex Characteristics; Sex Differences; Signal Transduction; Signal Transduction Systems; Signaling; Site; Testing; Time; TnI; Transphosphorylases; Troponin I; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Ventricular; Wild Type Mouse; Woman; Work; biological signal transduction; cardiac infarct; cardiac muscle; cardiovascular disorder; clinical significance; clinically significant; coronary attack; coronary infarct; coronary infarction; cost; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gender difference; gene product; genome mutation; heart attack; heart disorder; heart infarct; heart infarction; heart muscle; hydroxymethylglutaryl-CoA-reductase kinase; hyperpiesia; hyperpiesis; hypertensive disease; hypertrophic myocardiopathy; indexing; inhibitor; inhibitor/antagonist; inhibitory troponin I; male; men; men's; myosin heavy chain; pathophysiology; pathway; pressure; public health relevance; response; sex; sex dimorphism; sexual dimorphism; sexual dimorphism (noncellular); social role",Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathy," Males and females respond differently to cardiac disease such that males typically show signs of worsening cardiac function and females do not. The way males and females uniquely handle the energetic deficiencies associated with cardiac disease underlies these differences. Therefore, it is of major clinical significance that the mechanistic link be determined between cardiac disease, sex/gender differences and energetic regulators in the heart. )",98256,ZRG1,Special Emphasis Panel,,1,375191,
7766231,R01,HL,1,,01/12/2010,12/31/2010,PA-07-070,1R01HL098283-01,,NHLBI:670611;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"NEWTON-CHEH, CHRISTOPHER HOLMES;WANG, THOMAS J (contact);",2056870 (contact);7074148;,1R01HL098283,01/12/2010,12/31/2013,"Active Follow-up; Acute; Alleles; Allelomorphs; Atrial; Attention; Auricle of Heart; BACs (Chromosomes); BP control; Bacterial Artificial Chromosomes; Behavioral; Blood Pressure; Blood Pressure, High; Cardiac Atrium; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Signaling; Cells; Chemotherapy-Hormones/Steroids; Chronic; Clinical; DNA Resequencing; DNA Sequence; Data; Diet; Disease; Disorder; Echocardiogram; Echocardiography; Endocrine Gland Secretion; Equilibrium; Excretory function; Family Study; Feedback; Frequencies (time pattern); Frequency; Gene variant; General Population; General Public; Genetic; Genetic Diversity; Genetic Variation; Genotype; Heart; Heart Atrium; Heart myocyte; Hormones; Human; Human, General; Hypertension; In Vitro; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Intravenous; Investigation; Investigators; Kidney; Kidney Diseases; Man (Taxonomy); Man, Modern; Maps; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocytes, Cardiac; Na element; Natriuretic Peptide Hormones; Natriuretic Peptides; Nephropathy; Pathway interactions; Phenotype; Physiologic; Physiological; Prevalence; Proteins; Reading; Recruitment Activity; Renal Disease; Renin-Angiotensin-Aldosterone System; Reporting; Research; Research Personnel; Researchers; Resequencing; Rest; Risk; Role; Saline; Saline Solution; Sampling; Scandinavian; Signal Transduction; Signal Transduction Systems; Signaling; Sodium; Sodium Chloride; Sodium chloride (NaCl); Stress; Structure-Activity Relationship; Syndrome; System; System, LOINC Axis 4; System, Renin-Angiotensin-Aldosterone; Testing; Therapeutic Hormone; Transthoracic Echocardiography; Urinary System, Kidney; Variant; Variation; Variation (Genetics); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; allelic variant; association test; atrium; balance; balance function; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; cardiomyocyte; cardiovascular risk; cardiovascular risk factor; cerebrovascular; chemical structure function; disease/disorder; excretion; experience; follow-up; gene product; genetic association; genetic variant; heart sonography; hot climate; hyperpiesia; hyperpiesis; hypertensive disease; insight; interventional strategy; kidney disorder; molecular phenotype; natriuretic; normotensive; novel; pathway; population based; public health relevance; recruit; renal; renal disorder; response; salt; saluretic; social role; sound measurement; structure function relationship; trait; urinary",Physiologic effects of natriuretic peptide genetic variation," PUBLIC HEALTH RELEVANCE: High blood pressure leads to substantial morbidity and mortality, but its causes are not well established. The proposed research investigates the role of hormones produced by the heart in the regulation of blood pressure and responses to dietary salt, which could have important implications for behavioral and pharmacologic treatments to control blood pressure.",98283,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,1,670611,
7766535,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL098316-01,,NHLBI:423750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WALTER, JOHANNES ;",1871993;,1R01HL098316,02/01/2010,01/31/2014,"(SP-4-2)-Diamminedichloroplatinum; 2PP2A; Address; Affect; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Blood (Leukemia); Bone marrow failure; Bypass; CDDP; Cancers; Cell-Free System; Cellfree System; Cells; Chemicals; Chromatin; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Complex; Coupled; Cysplatyna; DDP; DNA; DNA Damage; DNA Double Strand Break; DNA Helicases; DNA Injury; DNA Interstrand Cross-Link Repair; DNA Polymerases; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA replication fork; DNA unwinding enzyme; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; DNA-dependent ATPase; DNA-dependent adenosinetriphosphatases; Defect; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Development; Dichlorodiammineplatinum; Disease; Disorder; EC 2.7.7.7; Egg Proteins; Environment; Event; Factor Analyses; Factor Analysis; Fanconi Anemia; Fanconi Anemia Complementation Group Protein; Fanconi anemia protein; Fanconi dysplasia; Fanconi's Anemia; Frog; Genetic; Genetic Condition; Genetic Diseases; Genetics, Human; Grant; HLA-DR Associated Protein II; Hereditary Disease; Human; Human Genetics; Human, General; I2PP2A; IGAAD; In Vitro; Incidence; Inhibitor of GZMA-Activated DNase; Knowledge; Laboratories; Lesion; Leukemias, General; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Manuscripts; Measures; Mitomycin Antibiotic; Mitomycins; Model System; Modeling; Models, Biologic; Molecular; Molecular Disease; Mono-S; MonoS; Nature; Nucleotides; Organism; Otomy; Ovum Proteins; PHAPII; Pancytopenia; Pancytopenia, Congenital; Panmyelopathy, Fanconi; Pathway interactions; Peyrone's Chloride; Peyrone's Salt; Phosphatase 2A Inhibitor I2PP2A; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Play; Polymerase; Position; Positioning Attribute; Predisposition; Preparation; Primary Erythroid Hypoplasia; Process; Proteins; Rana; Rana (genus); Recruitment Activity; Resistance; Role; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Set protein; Slide; Social Support System; Solid Neoplasm; Solid Tumor; Support System; Surgical incisions; Susceptibility; Syndrome; System; System, LOINC Axis 4; TAF-IBETA; Template Activating Factor I Beta; Testing; Xenopus; base; biochemical model; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; congenital aplastic anemia; cross-link; crosslink; disease/disorder; egg; experiment; experimental research; experimental study; gene product; genetic disorder; helicase; hereditary disorder; incision; insight; leukemia; living system; malignancy; mutant; neoplasm/cancer; pathway; public health relevance; recruit; repair; repaired; research study; resistant; social role; ubiquitin ligase",The Fanconi anemia pathway: role in DNA interstrand cross-link repair," Narrative Fanconi anemia (FA) is a cancer predisposition disorder which is caused by defects in a set of proteins that are thought to fix DNA inter-strand cross-links (ICLs), a particularly dangerous type of DNA damage. However, the mechanism by which the FA proteins normally fix ICLs is obscure. We have discovered that extracts derived from frog eggs recapitulate the process of ICL repair in a cell-free environment. We will use this system to elucidate the function of FA proteins in ICL repair.",98316,HP,Hematopoiesis Study Section,,1,423750,
7767448,R01,HL,1,,01/04/2010,11/30/2010,PA-07-070,1R01HL098481-01,,NHLBI:387500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,SURGERY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"CALVERT, JOHN WINTER;",8553005;,1R01HL098481,01/04/2010,11/30/2014,"Acute; Address; Affect; Antioxidants; Apoptosis; Apoptosis Pathway; Attenuated; Autoregulation; Biogenesis; Biological Models; Cardiac; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Caring; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cystathionine; Developed Countries; Developed Nations; Development; Drug Therapy; Dysfunction; Enzymes; Experimental Models; Experimental Models, Other; Foundations; Functional disorder; HDAC; HDAC Proteins; HO-1 enzyme; HO1; HO2; HSP32; HTRPY; Haem Oxygenase; Health; Healthcare; Heart; Heart Hypertrophy; Heart failure; Heme Oxygenase (Decyclizing); Heme,hydrogen-donor[{..}]oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating); Histone Deacetylase; Homeostasis; Hydrogen Sulfide; Hydrogen sulfide (H2S); Hypertrophy; In Vitro; Incidence; Industrialized Countries; Industrialized Nations; Injury; Intracellular Communication and Signaling; Ischemia; Ischemia-Reperfusion Injury; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; L-Homocysteine, S-(2-amino-2-carboxyethyl)-, (R)-; Lyase; Mammals, Mice; Mediating; Mice; Mitochondria; Model System; Modeling; Models, Biologic; Models, Experimental; Murine; Mus; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocardium; Nuclear; Organ System, Cardiovascular; Origin of Life; Oxidative Stress; Pharmacotherapy; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Play; Pressure; Pressure- physical agent; Prevalence; Regulation; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Staging; System; System, LOINC Axis 4; Testing; Therapeutic; Thioredoxin; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular, Heart; Work; anti-oxidant; biological signal transduction; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiac muscle; cardiovascular disorder; circulatory system; clinical relevance; clinically relevant; coronary attack; coronary infarct; coronary infarction; cost; design; designing; heart attack; heart infarct; heart infarction; heart ischemia; heart muscle; heme oxygenase-1; hemeoxygenase 1; hemodynamics; improved; in vitro Model; in vivo; in vivo Model; intervention design; meetings; mitochondrial; mitochondrial dysfunction; myocardial ischemia/hypoxia; myocardium ischemia; novel; nuclear respiratory factor; pathophysiology; pressure; protective effect; protein complex; protein expression; public health relevance; reperfusion; social role; therapy design; transcription factor; treatment design",Hydrogen sulfide attenuates heart failure through Nrf2-mediated signaling," Project Narrative Despite numerous advances in health care, cardiovascular disease remains the number one killer in the United States and heart failure, as a direct result of cardiovascular disease, affects nearly 5.3 million people in the United States resulting in about $34.8 billion being spent a year to cover associated health care related costs. The proposed studies will evaluate the efficacy of a hydrogen sulfide releasing compound in clinically relevant and highly translational experimental model systems of heart failure. The proposed studies will significantly advance our current understanding of the mechanisms responsible for the development of heart failure and will answer important questions regarding the signaling mechanism responsible for the cardioprotective effects of hydrogen sulfide in the setting of heart failure.",98481,MIM,Myocardial Ischemia and Metabolism Study Section,,1,387500,
7768551,R01,HL,1,,01/21/2010,12/31/2010,PA-07-070,1R01HL098489-01,,NHLBI:735238;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"KIEM, HANS-PETER ;",2094983;,1R01HL098489,01/21/2010,12/31/2013,"1,3-Bis(2-Chloroethyl)-1-Nitrosourea; 1,4-Bis(methanesulfonoxy)butane; 1,4-Bitanediol Dimethanesulfonate Esters; 1,4-Butanediol, dimethanesulfonate; 1,4-Di(methanesulfonyloxy)butane; 1,4-Di(methylsulfonyloxy)butane; 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; AMD-3100; AMD3100; Animal Model; Animal Models and Related Studies; Animals; Assay; B220; BCNU; Bioassay; Biologic Assays; Biological Assay; Bis-Chloronitrosourea; Blood; Blood Precursor Cell; Blood erythrocyte; Blood normocyte; Bussulfam; Busulfan; Busulfanum; CD34; CD34 gene; CD45; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Carmustine; Carmustine (BCNU); Cells; Cellular Oncogene; Chemoprotection; Chimpanzee foamy virus human isolate; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clonality; D2S201E; Data; Defect; Development; Disease; Disorder; Dose; Engraftment; Erythrocytes; Erythrocytic; Essex brand of temozolomide; FB22; FIVB; Foamy Virus; Future; GP180; Gammaretrovirus; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Modified; Gene-Tx; Genes; Genetic Condition; Genetic Diseases; Genetic Intervention; Genome; Globin; HM89; HPCA1; HSY3RR; Hematopoietic; Hematopoietic Stem Cell Mobilization; Hematopoietic stem cells; Hemoglobinopathies; Hemoglobinopathies / Iron Metabolism; Hereditary Disease; High Dose Chemotherapy; Homologous Transplantation; Human; Human Foamy Virus; Human Spumavirus; Human, General; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; In Vitro; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Insertional Mutagenesis; Intervention, Genetic; LAP3; LCA; LCR1; LESTR; LY5; Laboratories; Lentiviral Vector; Lentivirinae; Lentivirus; Lentivirus Vector; MGMT; MGMT gene; Macaca; Macaque; Mammals, Mice; Mammals, Primates; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mediating; Methanesulfonic acid, tetramethylene ester; Methods; Methods and Techniques; Methods, Other; Methylguanine-DNA Methyltransferase Gene; Mice; Modeling; Molecular Biology, Gene Therapy; Molecular Disease; Monitor; Monkeys; Mother Cells; Murine; Mus; Mutagenesis, Insertional; N,N'-Bis(2-Chloroethyl)-N-Nitrosourea; NPY3R; NPYR; NPYRL; NPYY3R; O element; O2 element; Oncogene Activation; Oxygen; PTPRC; PTPRC gene; Patients; Population; Primates; Progenitor Cells; Progenitor Cells, Hematopoietic; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proto-Oncogenes; Protocol; Protocols documentation; Radiation, Whole-Body; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regimen; Relative; Relative (related person); Reporting; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Retroviral Vector; Retrovirus Vector; Risk; Safety; Schering brand of temozolomide; Schering-Plough brand of temozolomide; Site; Spinal Column; Spine; Spumavirus; Stem Cell Mobilization; Stem cells; Subfamily lentivirinae; Sulfabutin; System; System, LOINC Axis 4; T200; Techniques; Temodal; Temodar; Testing; Tetramethylene bis[methanesulfonate]; Thalassemia; Therapeutic; Therapy, DNA; Time; Total Body Irradiation; Toxic effect; Toxicities; Transgenes; Translating; Translatings; Transplantation; Transplantation Conditioning; Transplantation Conditionings; Transplantation, Allogeneic; Transplantation, Homologous; Type C Retroviruses, Mammalian; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Vertebral column; Viral; Virus-Lenti; Whole-Body Irradiation; backbone; base; bis chloroethylnitrosourea; blood corpuscles; c-ONC; cell transduction; cellular transduction; chemotherapy; clinical investigation; clinical relevance; clinically relevant; conditioning; cytokine; disease/disorder; gene correction; gene product; gene therapy; gene-corrected; genetic disorder; genetic therapy; hematopoietic repopulating cell; hereditary disorder; hypoimmunity; imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-; immune deficiency disorder; immunodeficiency; improved; in vivo; language translation; mammalian type C retrovirus group; methazolastone; model organism; mouse model; non-human primate; nonhuman primate; novel; p-Globin; pre-clinical; preclinical; protooncogene; public health relevance; stem; temozolomide; transduced cells; transfer of a gene; transplant; treatment planning; vector; vector control",Development of safe and efficient gene therapy strategies for hemoglobinopathies," Project Narrative We propose to develop safer and more clinically applicable gene therapy treatment plans for genetic diseases in blood-forming stem cells, especially for defects in red blood cells which carry oxygen.",98489,ZRG1,Special Emphasis Panel,,1,735238,
7767246,R01,HL,1,,01/29/2010,11/30/2010,PA-07-070,1R01HL098511-01,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"MACIEJEWSKI, JAROSLAW P;",1863086;,1R01HL098511,01/29/2010,11/30/2013,"AML - Acute Myeloid Leukemia; Aberrant Chromosome; Abnormalities, Chromosomal; Acquired uniparental disomy; Adopted; Affect; Allelic Loss; Area; Blood (Leukemia); Blood Cells; Blood Precursor Cell; Bone Marrow; Bone marrow failure; CBL E3 ubiquitin protein ligase; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; CYTOGEN; Cancer Genes; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Signaling; Cells; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Clinical; Complement; Complement Proteins; Cytogenetic; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytogenetic Analyses; Cytogenetic Analysis; Cytogenetic Technics; Cytogenetic Techniques; Cytogenetics; DNA; DNA Alteration; DNA mutation; Defect; Deoxyribonucleic Acid; Detection; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Disorder; Dysmyelopoietic Syndromes; Dysplasia; E3 Ligase; E3 Ubiquitin Ligase; Evolution; Fingers; Forecast of outcome; Frequencies (time pattern); Frequency; Gene Alteration; Gene Mutation; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetics, Karyotyping; Genome Scan; Genomics; Germ Lines; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Hemoglobin H Disease; Heterogeneity; In Vitro; Individual; Intracellular Communication and Signaling; Investigation; Karyotype determination procedure; Karyotyping; Knock-in; Knock-in Mouse; Lead; Lesion; Leukemia, Myelocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemias, General; Link; Loss of Heterozygosity; Maps; Marrow; Mediating; Metaphase; Methods; Mitotic Metaphase; Molecular; Molecular Cytogenetic Technics; Molecular Cytogenetic Techniques; Molecular Target; Mutation; Myeloblastic Leukemia, Acute; Myelodysplastic Disease; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Disease; Myelogenous Leukemia, Acute; Myeloproliferative/Myelodysplastic Disorders; Myeloproliferative/Myelodysplastic Syndromes; OKT3 antigen; Oncogenes; Oncogenic; Outcome; PTK Receptors; Pancytopenia; Pathogenesis; Pathologic; Pathway interactions; Patients; Pb element; Peripheral Blood Cell; Play; Polymorphism, Single Base; Production; Progenitor Cells, Hematopoietic; Prognosis; Protein-Tyrosine Kinases, src; RTK; Receptor Protein-Tyrosine Kinases; Recurrence; Recurrent; Resolution; Reticuloendothelial System, Bone Marrow; Ring Finger; Ring Finger Domain; Ring Finger Motif; Ring-Type Zinc Finger Domain; Risk; Role; SNP; SNPs; Sampling; Scheme; Sequence Alteration; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Smoldering Leukemia; Sorting - Cell Movement; T3 Antigens; T3 Complex; T3 molecule; Testing; Transforming Genes; Translations; Transmembrane Receptor Protein Tyrosine Kinase; Tumor Suppressor Proteins; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Ubiquitin-Protein Ligase E3; Unbalanced Chromosomal Alteration; Unbalanced Chromosomal Alteration/Rearrangement; Unbalanced Chromosomal Rearrangement; Unbalanced Translocation; Uniparental Disomy; Variant; Variation; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; alpha-Thalassemia; attenuation; base; biological signal transduction; c-cbl protein; clinical phenotype; clinical practice; cytopenia; design; designing; disease/disorder; dyscrasia; genome mutation; heavy metal Pb; heavy metal lead; improved; leukemia; mutant; myelodysplasia; new therapeutic target; outcome forecast; pathway; prognostic; proto-oncogene protein c-cbl; public health relevance; secondary leukemia; social role; sorting; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; theories; therapeutic target; treatment associated acute myelogenous leukemia; tumor suppressor; ubiquitin-protein ligase",Molecular Pathogenesis of MDS and CMML," NARRATIVE Myelodysplastic syndromes (MDS) is a heterogeneous group of bone marrow failure states characterized by dysplastic hematopoiesis, deficient blood cell production and a propensity to progression to acute myelogenous leukemia (AML); this heterogeneity has greatly impeded investigations into the molecular pathogenesis and potential therapies for these diseases. We propose that single nucleotide polymorphisms arrays (SNP-A) can be applied, complementary to metaphase cytogenetics for the identification of chromosomal abnormalities, including a newly recognized class of lesion, somatic uniparental disomy. We will precisely map these lesions, identifying genes that may play a role in the disease and potentially act as targets of therapy.",98511,HP,Hematopoiesis Study Section,,1,392500,
7768056,R01,HL,1,,01/12/2010,11/30/2010,PA-07-070,1R01HL098538-01,,NHLBI:664239;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLOTTESVILLE,UNITED STATES,PHYSIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"OWENS, GARY K;",6402591;,1R01HL098538,01/12/2010,11/30/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; APOE [{C0003595}]; ATGN; Acetylation; Actins; Activation, Gene; Adenoviridae; Adenoviruses; Adventitial Cell; Angioplasty; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antigens; Antigens, Differentiation; Antiheparin Factor; Antiinflammatories; Antiinflammatory Agents; Aorta; Aortic arch structure; Apo-E; ApoE; ApoE knockout mouse; Apolipoprotein E; Apoptotic; Applications Grants; Arch of the Aorta; Arch, Aortic; Area; Arterial Fatty Streak; Assay; Asthma; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Automobile Driving; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Blood Platelet Factor IV; Blood Pressure, High; Blood Vessels; Blood platelet factor 4; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Bronchial Asthma; CCL2; CCL2 gene; CD106; CD106 Antigens; CHIP assay; CMV; Candidate Disease Gene; Candidate Gene; Cardiac artery; Cardiovascular Diseases; Carotid Arteries; Catheters; Cell Communication and Signaling; Cell Culture System; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chemokine (C-X-C motif) Ligand 4; Closure by Ligation; Collaborations; Combining Site; Common Rat Strains; Complex; Confocal Microscopy; Coronary; Coronary artery; Cytomegalovirus; DNA Binding; DNA Binding Interaction; Dermal; Development; Diet; Differentiation Antigens; Differentiation Markers; Differentiation and Growth; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drivings, Automobile; ES cell; Electrophoretic Mobility Shift Assay; Elements; Embryo; Embryonic; Endothelial Cells; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Factor 4; Femoral Artery; Fibroblasts; Figs; Figs - dietary; Freezing; Frequencies (time pattern); Frequency; GDCF-2; GDCF-2 HC11; Gel; Gene Activation; Gene Down-Regulation; Gene Expression; Gene Targeting; Genes; Genes, LacZ; Genetic Alteration; Genetic Change; Genetic defect; Globin; Goals; Grafting, Bone Marrow; Grant Proposals; Grants, Applications; HC11; HCMV; Heart artery; Heparin Neutralizing Protein; Histone Code; Human; Human, General; Hypertension; INCAM-110; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Situ Nick-End Labeling; In Vitro; In element; Indium; Inducible Cell Adhesion Molecule 110; Inflammatory; Injury; Intracellular Communication and Signaling; Intramural Program; Intramural Research Program; Knock-out; Knockout; Knockout Mice; Label; Laboratories; LacZ; LacZ Genes; Lead; Leiomyocyte; Lesion; Letters; Ligation; Liquid substance; MCAF; MCP-1; MCP1; MGC9434; MMP3; MMP3 gene; Maintenance; Maintenances; Mammals, Mice; Mammals, Rabbits; Mammals, Rats; Man (Taxonomy); Man, Modern; Marker Antigens; Markers, Differentation; Marrow Transplantation; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methylation; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microscopic; Microscopy, Confocal; Mobility Shift Assay; Modification; Molecular; Molecular Interaction; Mother Cells; Murine; Mus; Mutate; Mutation; Myocytes, Smooth Muscle; N element; N2 element; Neoplasm Metastasis; Nitrogen; Null Mouse; Oligo; Oligonucleotides; Oryctolagus cuniculus; PDGF; Pathogenesis; Pattern; Pb element; Peptides; Pericapillary Cell; Pericytes; Perivascular Cell; Phosphatides; Phospholipids; Platelet Factor 4; Platelet-Derived Growth Factor; Play; Process; Progenitor Cells; Proliferating; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Protein Methylation; RNA, Small Interfering; Rabbit, Domestic; Rabbits; Rat; Rattus; Reactive Site; Recombinant Platelet Factor 4; Recombinants; Regulation; Regulatory Element; RegulatoryElement; Relative; Relative (related person); Repression; Reticuloendothelial System, Bone Marrow; Role; Rouget Cells; SCYA2; SEQ-AN; SL-1; SMC-CF; STMY; STMY1; STR1; Salivary Gland Viruses; Sampling; Secondary Neoplasm; Secondary Tumor; Sequence Analyses; Sequence Analysis; Series; Shoulder; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Somatic Cell; Specificity; Staining method; Stainings; Stains; Stem cells; Streaks, Arterial Fatty; Structure of femoral artery; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TAM; TRANSIN; TUNEL; Tamoxifen; Targetings, Gene; Testing; Thymus-Dependent Lymphocytes; Time; Transcription Repression; Transcriptional Repression; Transgenes; Transgenic Mice; Transgenic Organisms; Trees; Tumor Cell Migration; VCAM; VCAM-1; Validation; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; aortic arch; atherogenesis; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; base; biological signal transduction; blood vessel disorder; cancer metastasis; cardiovascular disorder; cell type; chromatin immunoprecipitation; cohort; combinatorial; cultured cell line; cytomegalovirus group; disease/disorder; driving; effective therapy; embryonic stem cell; extracellular; fascinate; feeding; femoral artery; fluid; gamma-Thromboglobulin; gel shift assay; gene repression; genetic promoter element; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; histone modification; human cytomegalovirus; human disease; hyperpiesia; hyperpiesis; hypertensive disease; immunogen; in vivo; insight; interest; intraluminal angioplasty; liquid; loss of function; macrophage; man; man's; morphometry; mutant; myocardin; neointima formation; neointimal thickening; novel; p-Globin; platelet factor IV; pluripotency; public health relevance; reconstitute; reconstitution; response; self-renewal; siRNA; social role; stem; stem cell of embryonic origin; terminal nick end labeling; thymus derived lymphocyte; transgenic; tumor; vascular; vulnerable plaque",KLF4-Dependent Regulation of SMC Differentiation and Phenotypic Switching," Project Narrative Abnormal control of the differentiated state (i.e. cell specific properties) of vascular smooth muscle cells (SMC) is known to play a critical role in a number of major diseases including atherosclerosis, asthma, hypertension, and tumor metastasis. Studies in this proposal will provide novel insights into mechanisms that control SMC differentiation in development and disease and may lead to new and more effective therapies.",98538,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,1,664239,
7771616,R01,HL,1,,01/15/2010,12/31/2010,PA-07-070,1R01HL098634-01,,NHLBI:387676;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"EGHTESADY, PIROOZ ;",8421451;,1R01HL098634,01/15/2010,12/31/2014,"0-11 years old; ATGN; Accounting; Accreditation; Affect; Antibodies; Antigenic Determinants; Antigens; Aortic Valve; Aortic valve structure; Arthritis, Rheumatic, Acute; Autoantibodies; Award; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bicuspid Valve; Binding Determinants; Binetrakin; Birth; Blood; Blood Serum; Blood flow; Blotting, Western; Body Tissues; Cachectin; Cachectin-Tumor Necrosis Factor; Cardiac; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Diseases; Cardiac Disorders; Cardiac Malformation; Cardiac Muscle Myosins; Cardiac Myosins; Cardiac defect; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cell/Tissue, Immunohistochemistry; Child; Child Youth; Child health care; Childhood; Children (0-21); Clinical; Clinical Research; Clinical Study; Communities; Complex; Congenital Heart Defects; Constriction, Pathologic; Constriction, Pathological; Control Groups; Cross Infection; Data; Development; Disease; Disorder; ELISA; Echocardiogram; Echocardiography; Education; Educational aspects; Embryonic Tissue, Placenta; Ensure; Environment; Environmental Factor; Environmental Risk Factor; Enzyme-Linked Immunosorbent Assay; Epitopes; Exhibits; Family; Fetal Heart; Fetus; Gamma Globulin, 7S; General Population; General Public; Genetic; Gestation; Goals; Head and Neck, Pharynx; Health, Child; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Diseases; Heart Malformation; Heart Muscle tissue; History; Human; Human, Child; Human, General; Hypoplastic Left Heart Syndrome; Hypoplastic Left Ventricle; IHC; IL-4; IL4; IL4 Protein; IgG; Immune Markers; Immunoglobulin Deposition; Immunoglobulin G; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Markers; Immunologic, Immunochemical; Immunologics; In Situ; Infection; Inflammatory; Injury; Institutes; Interleukin-4; Interleukin-4 Precursor; Interrupted Aortic Arch; Intervention; Intervention Strategies; Lead; Left; Left Ventricles; Left ventricular structure; Lesion; Life; Longitudinal Studies; Lymphocyte Stimulatory Factor 1; MCGF-2; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Maternal antibody; Measurement; Medical; Medical Records; Mission; Mitral Stenosis; Mitral Valve; Mitral Valve Stenosis; Molecular; Molecular Mimicries; Molecular Mimicry; Morbidity; Morbidity - disease rate; Mothers; Myocardial; Myocardial tissue; Neonatal; Obstruction; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Parturition; Pathogenesis; Pathology; Patients; Pb element; Pharyngeal structure; Pharynx; Pharynxs; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Polyarthritis Rheumatica; Pregnancy; Pregnant Women; Prevention; Process; Programs (PT); Programs [Publication Type]; Public Health; QOL; Quality of life; Questionnaires; Reaction; Recording of previous events; Recruitment Activity; Recurrence; Recurrent; Reporting; Research; Research Resources; Research Specimen; Resources; Reticuloendothelial System, Blood; Rheumatic Fever; Rheumatic Heart Disease; Rheumatism, Articular, Acute; Rheumatisms, Acute Articular; SCHED; Sampling; Schedule; Science of Statistics; Selection Bias; Serum; Side; Social Support System; Specimen; Statistics; Stenosis; Streptococcal Infections; Streptococcus; Streptococcus infection; Structure; Support System; Surgeon; Surgical; Surgical Interventions; Surgical Management; Surgical Procedure; T-Cell Growth Factor 2; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Testing; Throat; Time; Tissues; Transthoracic Echocardiography; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Ventricular; Western Blotting; Western Blottings; Western Immunoblotting; alternative treatment; aortic valve; autoimmune antibody; care delivery; career; children; congenital cardiac disorder; congenital heart disease; congenital heart disorder; cytokine; delivery of care; disease/disorder; environmental risk; experience; fascinate; fetal; heart defect; heart disorder; heart sonography; heavy metal Pb; heavy metal lead; human TNF protein; immunogen; improved; in utero; inflammatory marker; innovate; innovation; innovative; interest; interventional strategy; long-term study; maternal serum; neonatal death; novel; palliation; pediatric; prevent; preventing; programs; protein blotting; public health medicine (field); public health relevance; recruit; repository; response; self reactive antibody; sound measurement; statistics; stem; streptolysin O; success; surgery; theories; tool; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; youngster",Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?," PROJECT NARRATIVE The proposed project has the potential to improve public health by preventing and/or defining alternative treatments for babies with Hypoplastic Left Heart Syndrome (HLHS), a devastating congenital heart defect. We propose to test a novel theory that there is a potential association between pharyngeal streptococcal infection or ""strep throat"" in mothers and the development of HLHS in their babies. If proven true, the findings will have a profound impact on this disease and the lives of many mothers and their affected babies.",98634,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,1,387676,
7787639,R01,HL,1,,01/18/2010,12/31/2010,PA-07-070,1R01HL098950-01,,NHLBI:406250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,BIOCHEMISTRY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"ZAIA, JOSEPH ;",3096391;,1R01HL098950,01/18/2010,12/31/2013,"2-Amino-2-Deoxyglucose; 2-dimensional; Address; Affinity; Anabolism; Angiogenesis, Pathologic; Angiogenesis, Pathological; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Blood Vessels; Body Tissues; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cell-Extracellular Matrix; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Characteristics; Chemicals; Chemistry, Biological; Chromatography; Chromatography / Separation Science; D-Glucose, 2-amino-2-deoxy-; DNA Synthesis Factor; Data; Disease; Disorder; Dissociation; Drugs; ECGF; ECM; Endothelial Cell Growth Factor; Environment; Enzymes; Event; Extracellular Matrix; Extracellular Space; FGF; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; GFAC; Generalized Growth; Glucosamine; Goals; Growth; Growth Agents; Growth Factor; Growth Factor Receptors; Growth Factors, Proteins; Growth Substances; HBGF; HPSE; HPSE Protein; Heparan Sulfate; Heparanase-1; Heparitin Sulfate; In Vitro; Inorganic Sulfates; Intercellular Space; Intracellular Communication and Signaling; Investigation; Ions; Length; Libraries; Liquid Chromatography; Lysosomes; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medication; Methods; Mitogenesis; Modification; Molecular Interaction; Neovascularization, Pathological; Oligosaccharides; Organ; Pathologic Neovascularization; Pharmaceutic Preparations; Pharmaceutical Preparations; Photometry/Spectrum Analysis, Mass; Play; Positive Control of Cell Proliferation; Property; Property, LOINC Axis 2; Protein Binding; Proteins; Proto-Oncogene, Growth Factor Receptor; Public Health; Receptor Activation; Research; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stimulation of Cell Proliferation; Stimulus; Structure; Structure-Activity Relationship; Subcellular Process; Sulfatases; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Surface; Therapeutic; Time; Tissue Growth; Tissues; Unspecified or Sulfate Ion Sulfates; Variant; Variation; Vascular Diseases; Vascular Disorder; Work; angiogenesis; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; biological systems; biosynthesis; blood vessel disorder; cell growth; chemical structure function; disease/disorder; drug/agent; enzyme activity; extracellular; gene product; heparan sulphate endoglycosidase; heparanase; high throughput analysis; in vivo; ontogeny; public health medicine (field); public health relevance; receptor binding; response; social role; structure function relationship; sulfate; sulfation; tandem mass spectrometry; two-dimensional; vascular",Post-biosynthetic remodeling of heparan sulfate," Relevance of this research to public health In vascular tissue, both normal and pathological cell growth related to angiogenesis is regulated through growth factor signaling cascades. Cells modulate their responses to growth factor signaling by altering the structures of heparan sulfate chains expressed on their surfaces and secreted into the extracellular matrix. This research will explore the structure-function relationships of vascular heparan sulfates in order to inform efforts to develop protein binding microarrays, drugs and therapeutics.",98950,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,1,406250,
7780738,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL098967-01A1,,NHLBI:567532;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","MISRA, SANJAY ;",6872702;,1R01HL098967,02/01/2010,01/31/2015,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Adventitia; Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Antibodies; Arteriovenous Aneurysm; Arteriovenous fistula; Arts; Avastin; Bevacizumab (rhuMAb VEGF); Blood Vessels; Catheters; Cell Culture Techniques; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; CellLine; Cells; Cellular Migration; Cellular Proliferation; Clinical; Clinical Trials; Clinical Trials, Unspecified; Constriction, Pathologic; Constriction, Pathological; Data; Deposit; Deposition; Dysfunction; ESRD; End stage renal failure; End-Stage Kidney Disease; FLR; Failure (biologic function); Fibroblasts; Functional disorder; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Gelatinases; Gene Expression; Goals; HBGF; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Harvest; Hemodialyses; Hemodialysis; Hyperplasia; Hyperplastic; Hypoxia; Hypoxic; In Vitro; Individual; Injury; Kidney Replacement Therapy; Knockout Mice; Knowledge; Lentivirinae; Lentivirus; MMP Inhibitor; MMP-2; MMP-9; MMP-9 Protein; MMP2; MMP9; MMPs; Macrophage Gelatinase; Maleates; Mammals, Mice; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Mediating; Mice; Mice, Knock-out; Mice, Knockout; MoAb VEGF; Modeling; Molecular; Monoclonal Antibody Anti-VEGF; Motility; Motility, Cellular; Murine; Mus; Myofibroblast; Nephrectomy; Null Mouse; Outcome; Oxygen Deficiency; PEX; PTK Inhibitors; Pathway interactions; Patient Care; Patient Care Delivery; Patients; Phenotype; Physiopathology; Play; Population; Production; Programs (PT); Programs [Publication Type]; Protein Tyrosine Kinase Inhibitors; Proteins; Rapamune; Rapamycin; Reagent; Receptor Protein; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Regulation; Renal Disease, End-Stage; Renal Replacement Therapy; Research Proposals; Research Specimen; RhuMAb VEGF; Role; Secondary to; Simvastatin; Sirolimus; Specimen; Stenosis; Subfamily lentivirinae; Sutent; Synvinolin; TK Inhibitors; Technology; Testing; Therapeutic; Translating; Translatings; Tunica Adventitia; Type V Collagenase; Tyrosine Kinase Inhibitor; VEGF Receptors; VEGFR; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vasculotropin; Vegf; Venous; Virus-Lenti; base; bevacizumab; cell motility; clinical investigation; cultured cell line; design; designing; experiment; experimental research; experimental study; failure; gain of function; gene product; hypoxia inducible factor 1; improved; in vivo Model; language translation; migration; neutralizing antibody; pathophysiology; pathway; programs; public health relevance; receptor; research study; rhuMabVEGF; shRNA; short hairpin RNA; small hairpin RNA; social role; therapeutic target; vascular",The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts," Public Health Relevance Statement: More than 400,000 patients in the US have end stage renal disease (ESRD), a population expected to double in the next decade. The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy.",98967,MEDI,Medical Imaging Study Section,A1,1,567532,
7800622,R01,HL,1,,02/01/2010,01/31/2011,PA-07-070,1R01HL099014-01,,NHLBI:372500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOUISVILLE,UNITED STATES,NONE,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"PRABHU, SUMANTH D;",1918960;,1R01HL099014,02/01/2010,01/31/2014,"2-Propenal; 4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; Ablation; Accounting; Acraldehyde; Acrolein; Acrylaldehyde; Acrylic Aldehyde; Active Oxygen; Affect; Aldehydes; Alleles; Allelomorphs; Allyl Aldehyde; Angiogenic Proteins; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Apoptosis; Apoptosis Pathway; Body Tissues; Bone Marrow; Cancers; Cardiac; Cardiomyopathies; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Closure by Ligation; Coronary; Depressed mood; Diagnostic; Diathesis; Disease; Disease susceptibility; Disorder; Drug Metabolic Detoxication; Dysfunction; EC 2.5.1.18; EC 2.7; Enzymes; Ethylene Aldehyde; FLR; Failure (biologic function); Fatty Acid Hydroperoxides; Fibrosis; Functional disorder; GST; Gene Expression; Generations; Genetic; Genetic Polymorphism; Glutathione; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione Transferase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; H2O2; Heart; Heart failure; Hematopoietic; Heme Transfer Protein; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; INFLM; Individual Differences; Infarction; Inflammation; Inflammatory; Injury; Intermediary Metabolism; Isoforms; Isotope Labeling; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; Kinases; LV remodeling; Left Ventricular Remodeling; Ligandins; Ligation; Lipid Hydroperoxide; Lipid Peroxidation; Lipid Peroxides; Lipoperoxides; MAP Kinase 8; MAPK8 Mitogen-Activated Protein Kinase; METBL; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measures; Membrane; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Mice; Mitogen-Activated Protein Kinase 8; Modeling; Mother Cells; Murine; Mus; Muscle Cells; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Mycocardium Disease; Myeloproliferation; Myocardial; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; Patients; Peroxidases; Peroxides; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiopathology; Play; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Pro-Oxidants; Process; Progenitor Cells; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; RX[{..}]glutathione R-transferase; Reactive Oxygen Species; Redox; Reticuloendothelial System, Bone Marrow; Role; S-Hydroxyalkyl Glutathione Lyase; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Se element; Selenium; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stem cells; Stress; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Subcellular Process; Susceptibility; Systemic disease; Testing; Therapeutic; Tissues; Transgenic Organisms; Transphosphorylases; Variant; Variation; Ventricle Remodelings, Left; Wild Type Mouse; Work; Xenobiotics; acryaldehyde; adduct; anti-oxidant; base; biological adaptation to stress; biomarker; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cardiac failure; cardiac muscle; chemotherapy; clinical investigation; cytotoxic; depressed; design; designing; detoxification; disease/disorder; disease/disorder proneness/risk; electron acceptor; failure; gain of function; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; glutathione aralkyltransferase; glutathione aryltransferase; heart muscle; in vivo; infarct; jun-NH2-Terminal Kinase; liability to disease; malignancy; membrane structure; myocardium disorder; neoplasm/cancer; neovascularization; novel; overexpression; oxidation reduction reaction; pathophysiology; peroxiredoxin; polymorphism; public health relevance; reaction; crisis; regenerative therapy; repair; repaired; response; sadness; social role; stress response; stress-activated protein kinase 1; stress; reaction; transgenic",Role of Glutathione S-Transferase P in Heart Failure," Relevance: These studies will establish glutathione S-transferase P (GSTP) as a critical antioxidant and tissue reparative protein in heart failure and identify new determinants of oxidative injury. Hence, the results can help design new, non-classical antioxidant and regenerative therapies in heart failure. We will also evaluate the cardioprotective potency of human GSTP variants in the failing heart; important differences between GSTP variants can establish a genetic basis for variability of antioxidant responses in the heart and provide a novel biomarker for the progression of heart failure.",99014,MIM,Myocardial Ischemia and Metabolism Study Section,,1,372500,
7855220,R01,HL,1,,01/07/2010,12/31/2010,HL-09-001,1R01HL101382-01,,NHLBI:386523;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,ANESTHESIOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"BENNETT-GUERRERO, ELLIOTT  (contact);STOWELL, CHRISTOPHER ;",6200143 (contact);9820605;,1R01HL101382,01/07/2010,12/31/2013,"Acute; Address; Age; Ancillary Study; Arm; Blood; Blood erythrocyte; Blood flow; Blood normocyte; Body Tissues; Boston; Cardiac; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Case Report Form; CaseReportForm; Cerebrum; Cessation of life; City of Boston; Clinical; Clinical Trials Network; Data; Data Base Management; Death; Deterioration; Dysfunction; Electronics; Enrollment; Erythrocyte Transfusion; Erythrocytes; Erythrocytic; Event; Functional disorder; Funding; Hemostasis; Hemostatic function; Hour; Image; Ischemia; Kidney; Laboratories; Lung; Marrow erythrocyte; Measurement; Measures; Mechanical ventilation; Medicine; Methods; Methods and Techniques; Methods, Other; Microcirculation; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; NIR Spectroscopy; National Institutes of Health; National Institutes of Health (U.S.); Near-Infrared Spectroscopy; New England; Northeastern United States; O element; O2 element; Observational Study; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Otomy; Outcome; Oxygen; Parents; Participant; Patients; Perfusion; Peripheral; Physiologic; Physiological; Physiopathology; Post-Operative; Postoperative; Postoperative Period; Randomized; Recovery; Red Blood Cell Transfusion; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research Institute; Respiratory System, Lung; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Retrospective Studies; Risk; Safety; Schools, Medical; Science of Medicine; Site; Skin; Spectrometry, Near-Infrared; Spectroscopy, Near-Infrared; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Surgical incisions; TRNSF; Techniques; Testing; Time; Tissue Viability; Tissues; Transfusion; Trauma; United States National Institutes of Health; Upper arm; Urinary System, Kidney; Viability, Tissue; Visually Impaired Persons; blind individual; blind people; blind person; blood corpuscles; cell bank; electronic data; enroll; experience; heart surgery; high risk; human study; imaging; incision; mechanical respiratory assist; medical schools; pathophysiology; prospective; public health relevance; pulmonary; randomisation; randomization; randomly assigned; renal; statistical service; surgery; tissue oxygen saturation; tissue oxygenation; visually impaired people",Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Study," Red blood cells (RBCs) are transfused to patients with the aim of increasing oxygen delivery to tissues in order to protect them from ischemia. There are some studies which indicate that transfusion of RBCs stored for a longer period of time may harm cardiac surgical patients. However, there are also studies that show no difference. The proposed ancillary study will provide important new information on whether longer storage duration of RBCs has a negative impact on tissue oxygenation and blood flow at the level of the microcirculation.",101382,ZHL1,Special Emphasis Panel,,1,386523,
7809216,R01,MD,1,,04/01/2010,12/31/2010,MD-09-004,1R01MD004065-01,,NCMHD:335920;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"ADIMORA, ADAORA A;",6607332;,1R01MD004065,04/01/2010,12/31/2014,"AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV prevention; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; African American; Afro American; Afroamerican; Age; Application Context; Attention; Attitude; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Belief; Black Populations; Black or African American; Communication; Communities; Conditioning Therapy; Condom; Condoms, Unspecified; County; Development; Development and Research; Epidemic; Evaluation; Focus Groups; Goals; HIV; HIV Infections; HIV Prevention; HIV test; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Communication; Heterosexuals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Individual; Intervention; Intervention Strategies; Knowledge; LAV-HTLV-III; Life Style Modification; Lymphadenopathy-Associated Virus; Mass Media; Math Models; Media Campaign; North Carolina; Outcome; Pattern; Phone; Play; Population; Population Decreases; Populations at Risk; Prevalence; Prevention; Prevention program; Publishing; R & D; R&D; Radio; Reporting; Research; Risk; Risk Factors; Role; Rural; STD; Sex Behavior; Sexual Activity; Sexual Behavior; Sexual Partners; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Source; Speed; Speed (motion); Survey Instrument; Surveys; T-Lymphotropic Virus Type III Infections, Human; TV; Telephone; Television; Testing; Time; Transmission; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Woman; Work; aged; base; behavior intervention; behavioral intervention; black American; condoms; contextual factors; design; designing; expectation; experience; interventional strategy; mass information media; mathematical model; mathematical modeling; men; men's; research and development; response; safer sex; sex activity; sex partner; simulation; social; social role; socioeconomic; socioeconomically; socioeconomics; transmission process; willingness",HIV Prevention among African Americans: A Media Campaign," This application proposes development and implementation of a mass media campaign to decrease concurrent partnerships, a sexual network pattern that promotes HIV transmission. This study represents a critical first step in the development and more definitive testing of a multi-component mass communication HIV prevention program for African Americans in the rural Southeast and throughout the nation.",4065,ZMD1,Special Emphasis Panel,,1,335920,
7780181,R01,MH,1,,01/15/2010,12/31/2010,PA-07-092,1R01MH080906-01A2,,NIMH:241762;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ROCHESTER,UNITED STATES,PEDIATRICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"SMITH, TRISTRAM H;",1912139;,1R01MH080906,01/15/2010,12/31/2014,"0-11 years old; 1-5 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; 7 year old; Accountability; Address; Advocate; Affect; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Aggression; Aggressive behavior; Agreement; Aman; Amendment; Analysis, Data; Arts; Asperger Syndrome; Asperger's Disorder; Attention; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blinded; Budgets; Bylaw; Child; Child Behavior; Child Development Disorders; Child Youth; Child, Preschool; Childhood; Children (0-21); Chronic; Clinical; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Communication; Communities; Conditioning Therapy; Consensus; Data; Data Analyses; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Decision Making; Deliberate Self-Harm; Development; Developmental Disabilities; Diagnosis; Education, Parenting; Educational process of instructing; Effectiveness; Enrollment; Ensure; Ethics Committees, Research; Evidence based intervention; Explosion; Faculty; Family; Funding; Genetic; Government; Hexal Brand of Amantadine Sulfate; History; Home; Home environment; Hospitals, Pediatric; Hour; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRBs; IT Systems; Indiana; Informatics; Information Systems; Information Technology Systems; Institutional Review Boards; Intervention; Intervention Strategies; Intervention Trial; Investigators; Kanner's Syndrome; Laboratories; Language; Language Tests; Laws; Leadership; Left; Letters; Life; Life Style Modification; Manuals; Measurement; Measures; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Methylphenidate; Monitor; NIH; NIH Program Announcements; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Neuro Hexal Brand of Amantadine Sulfate; Neurobiology; Newly Diagnosed; Nursery Schools; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; P50 Mechanism; P50 Program; Paper; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting Education; Parenting behavior; Parents; Pediatric Hospitals; Pervasive Development Disorder; Pervasive Developmental Disorder; Pharmacology-Psychopharmacology; Phase; Policies; Population; Position; Positioning Attribute; Positive Reinforcements; Postdoc; Postdoctoral Fellow; Preschool Child; Prevalence; Principal Investigator; Problem behavior; Procedures; Program Announcement; Program Reviews; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychologist; Psychopharmacology; Psychopharmacology / Toxicology; Public Health; Publications; Quality Control; Quality, Data; Questionnaires; Random Allocation; Random Selection; Randomized; Recommendation; Recording of previous events; Records; Reinforcements, Positive; Reporting; Research; Research Associate; Research Ethics Committees; Research Personnel; Researchers; Risperidone; Role; Safety; Safety Monitoring Boards; School-Age Population; Schools, Nursery; Scientific Publication; Self-Injurious Behavior; Series; Services; Severities; Site; Site Visit; Soaps; Socialization; Socializations; Solid; Specialized Center; Specific qualifier value; Specified; Stress; Structure; Study Subject; Supervision; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Teaching; Techniques; Teleconferences; Testing; Therapeutic Intervention; Time; TimeLine; Training; Training Programs; United States National Institute of Mental Health; United States National Institutes of Health; Universities; Unspecified Mental Disorder; Variant; Variation; Video Recording; Videorecording; Visit; Vulnerable Populations; Work; Writing; age group; analog; autism spectrum disorder; base; behavior intervention; behavioral intervention; behavioral problem; blind; children; clinical practice; data management; deliberate self harm; design; designing; developmental disease/disorder; developmental disorder; disability; early childhood; effective therapy; enroll; evidence base; experience; follow up assessment; impression; improved; indexing; intentional self harm; intentional self injury; interest; intervention development; intervention therapy; interventional strategy; meetings; mental illness; neurobiological; non-compliance; parent child interaction; parent offspring interaction; parental role; pediatric; post-doc; post-doctoral; preschool child (1-5); primary outcome; programs; psychoeducation; psychoeducational intervention; psychological disorder; psychosocial; public health medicine (field); public health relevance; publication formats; quality assurance; randomisation; randomization; randomized trial; randomly assigned; resperidone; response; role of parent; school age; self harm; self injury; seven year old; skills; social; social communication; social role; statistical service; statistics/biometry; surgery; teacher; therapy development; treatment development; video recording system; web based interface; youngster",3/5-Randomized Trial of Parent Training for Young Children with Autism," Relevance. There is an urgent need for large-scale, methodologically rigorous studies to develop evidence-based interventions for children with autism. This trial is designed to address this need by providing information on optimal practices for educating parents to be effective teachers and advocates for their young children.",80906,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,241762,
7782836,R01,MH,1,,01/15/2010,12/31/2010,PA-07-092,1R01MH080965-01A2,,NIMH:238613;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PEDIATRICS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"JOHNSON, CYNTHIA R;",1964303;,1R01MH080965,01/15/2010,12/31/2014,"0-11 years old; 1-5 years old; 7 year old; Accountability; Address; Advocate; Affect; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Aggression; Aggressive behavior; Agreement; Asperger Syndrome; Asperger's Disorder; Attention; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blinded; Child; Child Behavior; Child Youth; Child, Preschool; Childhood; Children (0-21); Clinical; Communication; Communities; Conditioning Therapy; Data; Deliberate Self-Harm; Development; Education, Parenting; Effectiveness; Enrollment; Ensure; Ethics Committees, Research; Evidence based intervention; Family; Government; Home; Home environment; Hour; Human, Child; IRBs; Indiana; Institutional Review Boards; Intervention; Intervention Strategies; Investigators; Kanner's Syndrome; Laboratories; Left; Life; Life Style Modification; Measures; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Monitor; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Research Council; National Research Council (U.S.); Newly Diagnosed; Nursery Schools; Ohio; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting Education; Parenting behavior; Parents; Pervasive Development Disorder; Pervasive Developmental Disorder; Pharmacology-Psychopharmacology; Phase; Population; Positive Reinforcements; Preschool Child; Prevalence; Procedures; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychopharmacology; Psychopharmacology / Toxicology; Public Health; Questionnaires; Randomized; Recommendation; Reinforcements, Positive; Research; Research Ethics Committees; Research Personnel; Researchers; Schools, Nursery; Self-Injurious Behavior; Services; Severities; Site; Soaps; Socialization; Socializations; Specific qualifier value; Specified; Stress; Structure; Techniques; Testing; Time; TimeLine; Training; Training Programs; United States National Institute of Mental Health; Universities; Unspecified Mental Disorder; Variant; Variation; Video Recording; Videorecording; age group; analog; autism spectrum disorder; base; behavior intervention; behavioral intervention; blind; children; data management; deliberate self harm; design; designing; developmental disease/disorder; developmental disorder; disability; early childhood; enroll; experience; follow up assessment; impression; improved; indexing; intentional self harm; intentional self injury; interest; interventional strategy; mental illness; non-compliance; parent child interaction; parent offspring interaction; parental role; pediatric; preschool child (1-5); primary outcome; programs; psychoeducation; psychoeducational intervention; psychological disorder; psychosocial; public health medicine (field); public health relevance; quality assurance; randomisation; randomization; randomized trial; randomly assigned; response; role of parent; self harm; self injury; seven year old; skills; social; social communication; statistical service; teacher; video recording system; youngster",5/5-Randomized Trial of Parent Training for Young Children with Autism," PROJECT RELEVANCE There is an urgent need for large-scale, methodologically rigorous studies to develop evidence-based interventions for children with autism. This trial is designed to address this need by providing information on optimal practices for educating parents to be effective teachers and advocates for their young children.",80965,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,238613,
7783408,R01,MH,1,,01/15/2010,12/31/2010,PA-07-092,1R01MH081105-01A2,,NIMH:230104;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,COLUMBUS,UNITED STATES,PSYCHOLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"LECAVALIER, LUC ;",10418802;,1R01MH081105,01/15/2010,12/31/2014,"0-11 years old; 1-5 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; 7 year old; Accountability; Address; Advocate; Affect; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Aggression; Aggressive behavior; Agreement; Aman; Amendment; Analysis, Data; Arts; Asperger Syndrome; Asperger's Disorder; Attention; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blinded; Budgets; Bylaw; Child; Child Behavior; Child Development Disorders; Child Youth; Child, Preschool; Childhood; Children (0-21); Chronic; Clinical; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Communication; Communities; Conditioning Therapy; Consensus; Data; Data Analyses; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Decision Making; Deliberate Self-Harm; Development; Developmental Disabilities; Diagnosis; Education, Parenting; Educational process of instructing; Effectiveness; Enrollment; Ensure; Ethics Committees, Research; Evidence based intervention; Explosion; Faculty; Family; Funding; Genetic; Government; Hexal Brand of Amantadine Sulfate; History; Home; Home environment; Hospitals, Pediatric; Hour; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRBs; IT Systems; Indiana; Informatics; Information Systems; Information Technology Systems; Institutional Review Boards; Intervention; Intervention Strategies; Intervention Trial; Investigators; Kanner's Syndrome; Laboratories; Language; Language Tests; Laws; Leadership; Left; Letters; Life; Life Style Modification; Manuals; Measurement; Measures; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Methylphenidate; Monitor; NIH; NIH Program Announcements; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Neuro Hexal Brand of Amantadine Sulfate; Neurobiology; Newly Diagnosed; Nursery Schools; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; P50 Mechanism; P50 Program; Paper; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting Education; Parenting behavior; Parents; Pediatric Hospitals; Pervasive Development Disorder; Pervasive Developmental Disorder; Pharmacology-Psychopharmacology; Phase; Policies; Population; Position; Positioning Attribute; Positive Reinforcements; Postdoc; Postdoctoral Fellow; Preschool Child; Prevalence; Principal Investigator; Problem behavior; Procedures; Program Announcement; Program Reviews; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychologist; Psychopharmacology; Psychopharmacology / Toxicology; Public Health; Publications; Quality Control; Quality, Data; Questionnaires; Random Allocation; Random Selection; Randomized; Recommendation; Recording of previous events; Records; Reinforcements, Positive; Reporting; Research; Research Associate; Research Ethics Committees; Research Personnel; Researchers; Risperidone; Role; Safety; Safety Monitoring Boards; School-Age Population; Schools, Nursery; Scientific Publication; Self-Injurious Behavior; Series; Services; Severities; Site; Site Visit; Soaps; Socialization; Socializations; Solid; Specialized Center; Specific qualifier value; Specified; Stress; Structure; Study Subject; Supervision; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Teaching; Techniques; Teleconferences; Testing; Therapeutic Intervention; Time; TimeLine; Training; Training Programs; United States National Institute of Mental Health; United States National Institutes of Health; Universities; Unspecified Mental Disorder; Variant; Variation; Video Recording; Videorecording; Visit; Vulnerable Populations; Work; Writing; age group; analog; autism spectrum disorder; base; behavior intervention; behavioral intervention; behavioral problem; blind; children; clinical practice; data management; deliberate self harm; design; designing; developmental disease/disorder; developmental disorder; disability; early childhood; effective therapy; enroll; evidence base; experience; follow up assessment; impression; improved; indexing; intentional self harm; intentional self injury; interest; intervention development; intervention therapy; interventional strategy; meetings; mental illness; neurobiological; non-compliance; parent child interaction; parent offspring interaction; parental role; pediatric; post-doc; post-doctoral; preschool child (1-5); primary outcome; programs; psychoeducation; psychoeducational intervention; psychological disorder; psychosocial; public health medicine (field); public health relevance; publication formats; quality assurance; randomisation; randomization; randomized trial; randomly assigned; resperidone; response; role of parent; school age; self harm; self injury; seven year old; skills; social; social communication; social role; statistical service; statistics/biometry; surgery; teacher; therapy development; treatment development; video recording system; web based interface; youngster",2/5-Randomized Trial of Parent Training for Young Children with Autism," Relevance. There is an urgent need for large-scale, methodologically rigorous studies to develop evidence-based interventions for children with autism. This trial is designed to address this need by providing information on optimal practices for educating parents to be effective teachers and advocates for their young children.",81105,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,230104,
7783088,R01,MH,1,,01/15/2010,12/31/2010,PA-07-092,1R01MH081148-01A2,,NIMH:447909;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,NONE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SCAHILL, LAWRENCE D.;",7361234;,1R01MH081148,01/15/2010,12/31/2014,"0-11 years old; 1-5 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; 7 year old; Accountability; Address; Advocate; Affect; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Aggression; Aggressive behavior; Agreement; Aman; Amendment; Analysis, Data; Arts; Asperger Syndrome; Asperger's Disorder; Attention; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blinded; Budgets; Bylaw; Child; Child Behavior; Child Development Disorders; Child Youth; Child, Preschool; Childhood; Children (0-21); Chronic; Clinical; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Communication; Communities; Conditioning Therapy; Consensus; Data; Data Analyses; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Decision Making; Deliberate Self-Harm; Development; Developmental Disabilities; Diagnosis; Education, Parenting; Educational process of instructing; Effectiveness; Enrollment; Ensure; Ethics Committees, Research; Evidence based intervention; Explosion; Faculty; Family; Funding; Genetic; Government; Hexal Brand of Amantadine Sulfate; History; Home; Home environment; Hospitals, Pediatric; Hour; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRBs; IT Systems; Indiana; Informatics; Information Systems; Information Technology Systems; Institutional Review Boards; Intervention; Intervention Strategies; Intervention Trial; Investigators; Kanner's Syndrome; Laboratories; Language; Language Tests; Laws; Leadership; Left; Letters; Life; Life Style Modification; Manuals; Measurement; Measures; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Methylphenidate; Monitor; NIH; NIH Program Announcements; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Neuro Hexal Brand of Amantadine Sulfate; Neurobiology; Newly Diagnosed; Nursery Schools; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; P50 Mechanism; P50 Program; Paper; Parent-Child Relations; Parent-Child Relationship; Parenting Education; Parents; Pediatric Hospitals; Pervasive Development Disorder; Pervasive Developmental Disorder; Pharmacology-Psychopharmacology; Phase; Policies; Population; Position; Positioning Attribute; Positive Reinforcements; Postdoc; Postdoctoral Fellow; Preschool Child; Prevalence; Principal Investigator; Problem behavior; Procedures; Program Announcement; Program Reviews; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychologist; Psychopharmacology; Psychopharmacology / Toxicology; Public Health; Publications; Quality Control; Quality, Data; Questionnaires; Random Allocation; Random Selection; Randomized; Recommendation; Recording of previous events; Records; Reinforcements, Positive; Reporting; Research; Research Associate; Research Ethics Committees; Research Personnel; Researchers; Risperidone; Role; Safety; Safety Monitoring Boards; School-Age Population; Schools, Nursery; Scientific Publication; Self-Injurious Behavior; Series; Services; Severities; Site; Site Visit; Soaps; Socialization; Socializations; Solid; Specialized Center; Specific qualifier value; Specified; Stress; Structure; Study Subject; Supervision; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Teaching; Techniques; Teleconferences; Testing; Therapeutic Intervention; Time; TimeLine; Training; Training Programs; United States National Institute of Mental Health; United States National Institutes of Health; Universities; Unspecified Mental Disorder; Variant; Variation; Video Recording; Videorecording; Visit; Vulnerable Populations; Work; Writing; age group; analog; autism spectrum disorder; base; behavior intervention; behavioral intervention; behavioral problem; blind; children; clinical practice; data management; deliberate self harm; design; designing; developmental disease/disorder; developmental disorder; disability; early childhood; effective therapy; enroll; evidence base; experience; follow up assessment; impression; improved; indexing; intentional self harm; intentional self injury; interest; intervention development; intervention therapy; interventional strategy; meetings; mental illness; neurobiological; non-compliance; parent child interaction; parent offspring interaction; parental role; pediatric; post-doc; post-doctoral; preschool child (1-5); primary outcome; programs; psychoeducation; psychoeducational intervention; psychological disorder; psychosocial; public health medicine (field); public health relevance; publication formats; quality assurance; randomisation; randomization; randomized trial; randomly assigned; resperidone; response; role of parent; school age; self harm; self injury; seven year old; skills; social; social communication; social role; statistical service; statistics/biometry; surgery; teacher; therapy development; treatment development; video recording system; web based interface; youngster",1/5-Randomized Trial of Parent Training for Young Children with Autism," PROJECT RELEVANCE There is an urgent need for large-scale, methodologically rigorous studies to develop evidence-based interventions for children with autism. This trial is designed to address this need by providing information on optimal practices for educating parents to be effective teachers and advocates for their young children.",81148,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,447909,
7780569,R01,MH,1,,01/15/2010,12/31/2010,PA-07-092,1R01MH081221-01A2,,NIMH:242552;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,INDIANAPOLIS,UNITED STATES,PSYCHIATRY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"SWIEZY, NAOMI BETH;",8797352;,1R01MH081221,01/15/2010,12/31/2014,"0-11 years old; 1-5 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; 7 year old; Accountability; Address; Advocate; Affect; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Aggression; Aggressive behavior; Agreement; Aman; Amendment; Analysis, Data; Arts; Asperger Syndrome; Asperger's Disorder; Attention; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blinded; Budgets; Bylaw; Child; Child Behavior; Child Development Disorders; Child Youth; Child, Preschool; Childhood; Children (0-21); Chronic; Clinical; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Communication; Communities; Conditioning Therapy; Consensus; Data; Data Analyses; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Decision Making; Deliberate Self-Harm; Development; Developmental Disabilities; Diagnosis; Education, Parenting; Educational process of instructing; Effectiveness; Enrollment; Ensure; Ethics Committees, Research; Evidence based intervention; Explosion; Faculty; Family; Funding; Genetic; Government; Hexal Brand of Amantadine Sulfate; History; Home; Home environment; Hospitals, Pediatric; Hour; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRBs; IT Systems; Indiana; Informatics; Information Systems; Information Technology Systems; Institutional Review Boards; Intervention; Intervention Strategies; Intervention Trial; Investigators; Kanner's Syndrome; Laboratories; Language; Language Tests; Laws; Leadership; Left; Letters; Life; Life Style Modification; Manuals; Measurement; Measures; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Methylphenidate; Monitor; NIH; NIH Program Announcements; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Neuro Hexal Brand of Amantadine Sulfate; Neurobiology; Newly Diagnosed; Nursery Schools; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; P50 Mechanism; P50 Program; Paper; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting Education; Parenting behavior; Parents; Pediatric Hospitals; Pervasive Development Disorder; Pervasive Developmental Disorder; Pharmacology-Psychopharmacology; Phase; Policies; Population; Position; Positioning Attribute; Positive Reinforcements; Postdoc; Postdoctoral Fellow; Preschool Child; Prevalence; Principal Investigator; Problem behavior; Procedures; Program Announcement; Program Reviews; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychologist; Psychopharmacology; Psychopharmacology / Toxicology; Public Health; Publications; Quality Control; Quality, Data; Questionnaires; Random Allocation; Random Selection; Randomized; Recommendation; Recording of previous events; Records; Reinforcements, Positive; Reporting; Research; Research Associate; Research Ethics Committees; Research Personnel; Researchers; Risperidone; Role; Safety; Safety Monitoring Boards; School-Age Population; Schools, Nursery; Scientific Publication; Self-Injurious Behavior; Series; Services; Severities; Site; Site Visit; Soaps; Socialization; Socializations; Solid; Specialized Center; Specific qualifier value; Specified; Stress; Structure; Study Subject; Supervision; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Teaching; Techniques; Teleconferences; Testing; Therapeutic Intervention; Time; TimeLine; Training; Training Programs; United States National Institute of Mental Health; United States National Institutes of Health; Universities; Unspecified Mental Disorder; Variant; Variation; Video Recording; Videorecording; Visit; Vulnerable Populations; Work; Writing; age group; analog; autism spectrum disorder; base; behavior intervention; behavioral intervention; behavioral problem; blind; children; clinical practice; data management; deliberate self harm; design; designing; developmental disease/disorder; developmental disorder; disability; early childhood; effective therapy; enroll; evidence base; experience; follow up assessment; impression; improved; indexing; intentional self harm; intentional self injury; interest; intervention development; intervention therapy; interventional strategy; meetings; mental illness; neurobiological; non-compliance; parent child interaction; parent offspring interaction; parental role; pediatric; post-doc; post-doctoral; preschool child (1-5); primary outcome; programs; psychoeducation; psychoeducational intervention; psychological disorder; psychosocial; public health medicine (field); public health relevance; publication formats; quality assurance; randomisation; randomization; randomized trial; randomly assigned; resperidone; response; role of parent; school age; self harm; self injury; seven year old; skills; social; social communication; social role; statistical service; statistics/biometry; surgery; teacher; therapy development; treatment development; video recording system; web based interface; youngster",4/5-Randomized Trial of Parent Training for Young Children with Autism," PROJECT RELEVANCE There is an urgent need for large-scale, methodologically rigorous studies to develop evidence-based interventions for children with autism. This trial is designed to address this need by providing information on optimal practices for educating parents to be effective teachers and advocates for their young children.",81221,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,242552,
7781077,R01,MH,1,,01/06/2010,11/30/2010,PA-07-070,1R01MH083744-01A2,,NIMH:497720;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"AHVENINEN, JYRKI ;",8800973;,1R01MH083744,01/06/2010,11/30/2013,"Analysis, Area; Area; Area Analyses; Attention; Auditory; Auditory Cortex; Auditory Localization; Auditory Pathways; Auditory area; Auditory pathway structure; Behavior; Behavioral; Brain; Brain imaging; Brain region; Causality; Cognition; Cognitive; Conflict; Conflict (Psychology); Cortical Synchronization; Coupling; Cues; Data; Detection; Disease; Disorder; Distant; EEG; Electroencephalography; Encephalon; Encephalons; Etiology; Event-Related Potentials; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Goals; Human; Human, General; Image; Imaging Procedures; Imaging Techniques; Inferior; Investigation; Life; Location; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Magnetoencephalography; Man (Taxonomy); Man, Modern; Measures; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; Motor Cortex; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear Magnetic Resonance Imaging; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Participant; Pattern; Phase; Physiologic; Physiological; Play; Population; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Relative; Relative (related person); Research; Research Resources; Resolution; Resource Allocation; Resources; Role; Selective inattention; Sensory; Sound; Sound - physical agent; Sound Localization; Source; Spottings; System; System, LOINC Axis 4; Task Performances; Technics, Imaging; Techniques; Testing; Time; Work; Zeugmatography; auditory pathway; brain visualization; cognitive control; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environmental change; event related potential; fMRI; frontal cortex; frontal lobe; imaging; imaging modality; information processing; insight; neuronal; parietal cortex; programs; public health relevance; response; selective attention; social role; sound; spatiotemporal",Dynamic imaging of oscillatory brain networks controlling selective attention, PROJECT NARRATIVE We will use advanced brain imaging methods to investigate how neurons in different brain areas work together to enable attention and cognitive control during auditory information processing. Our results may also support investigation of disorders with abnormal cognitive control functions.,83744,ZRG1,Special Emphasis Panel,A2,1,497720,
7795568,R01,MH,1,,01/06/2010,11/30/2010,PA-07-070,1R01MH083990-01A2,,NIMH:414016;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"PERERA, TARIQUE DHYAN;",7122684;,1R01MH083990,01/06/2010,11/30/2014,"21+ years old; Ablation; Accounting; Acute; Address; Adult; Adverse effects; Age; Ammon Horn; Animals; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Anxiety; Anxiety Disorders; Attenuated; Beginning of Human Life; Behavior; Behavioral; Bonnet Macaques; Brain; Cephalic; Chronic; Chronic stress; Clinical; Control Groups; Convulsive Therapy, Electric; Cornu Ammonis; Cranial; Data; Depression; Derivation; Derivation procedure; Drugs; Economic Burden; Electroconvulsive Psychotherapy; Electroconvulsive Shock Therapy; Electroconvulsive Therapy; Electroconvulsive treatment; Electroshock Psychotherapy; Electroshock Therapy; Electroshock treatment; Elements; Emotional Depression; Encephalon; Encephalons; Endogenous depression; Ensoulment; Ensoulments; Fluoxetin; Fluoxetine; Generations; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; Hyperplasia; Hyperplastic; Laboratories; Lead; Learning; Location; Macaca radiata; Major Depressive Disorder; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Memory Deficit; Memory impairment; Mental Depression; Mice; Modeling; Monkey, Bonnet; Monkeys; Moods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Growth; Neural Pathways; Neural Stem Cell; Neurobiology; Neurocyte; Neuronal Growth; Neurons; Pathogenesis; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Predisposing Factor; Prevalence; Prevention; Process; Production; Property; Property, LOINC Axis 2; Recruitment Activity; Regulation; Resistance; Risk; Rodent; Rodentia; Rodentias; Role; Shock Therapy, Electric; Simulate; Speed; Speed (motion); Staging; Stimulus; Stress; Symptoms of depression; Syndrome; Testing; Therapeutic; Therapeutic Effect; Treatment Side Effects; adult human (21+); base; clinical depression; clinical relevance; clinically relevant; depressive; depressive symptoms; design; designing; drug/agent; electric shock treatment; electro-convulsive therapy; electroplexy shock therapy; expectation; heavy metal Pb; heavy metal lead; hippocampal; irradiation; major depression; nerve stem cell; neural circuit; neural circuitry; neural progenitor cells; neurobiological; neurobiological mechanism; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; pre-clinical; preclinical; prevent; preventing; public health relevance; radiatas, Macaca; recruit; regional difference; resistant; response; shock treatment; side effect; social; social role; therapy adverse effect; treatment adverse effect",Necessity of Neurogenesis for Antidepressant Efficacy," Narrative Depression is a devastating and common illness, yet treatments are not universally effective because their mechanisms are only partially understood. Recent evidence from our laboratory and others' suggests that the production of new nerve cells in the brain is critical for antidepressants to treat depression. Since we cannot study new neurons in humans we will conduct a project to test this hypothesis in monkeys because of their similarity to humans.",83990,ZRG1,Special Emphasis Panel,A2,1,414016,
7790468,R01,MH,1,,01/06/2010,11/30/2010,PA-07-070,1R01MH085069-01A2,,NIMH:323197;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DAVIS,UNITED STATES,PSYCHOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"TRAINOR, BRIAN C;",6776297;,1R01MH085069,01/06/2010,11/30/2013,"2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Affect; Affective Psychosis, Bipolar; Aggression; Aggressive behavior; Ammon Horn; Animals; Aquadiol; Automobile Driving; BPD; Behavior; Behavioral; Bipolar Disorder; Blotting, Western; Borderline Personality Disorder; Brain; Brain region; CRE Binding Protein; CREB; CREB Protein; California; Cell Nucleus; Cell/Tissue, Immunohistochemistry; Cells; Chemotherapy-Hormones/Steroids; Cicloheximide; Clinical Trials; Clinical Trials, Unspecified; Complex; Cornu Ammonis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Cycloheximide; Cytoplasm; D-His-6-Pro-8-NEt-LHRH; Data; Dimenformon; Diogyn; Diogynets; Drivings, Automobile; ERK MAP Kinases; Encephalon; Encephalons; Endocrine Gland Secretion; Environment; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; FSH-Releasing Hormone; Feedback; Gene Expression; Gene Transcription; Genetic Transcription; Genomics; GnRH (gonadotropin releasing hormone); Gonadal Hormones; Gonadoliberin; Gonadorelinum; Gonadotropin Hormone Releasing Hormone; Gonadotropin-Releasing Hormone; Hippocampus; Hippocampus (Brain); Hoe- 471; Hormones; House mice; Human; Human, General; Hypothalamic structure; Hypothalamus; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Injection of therapeutic agent; Injections; Investigators; LH-FSH Releasing Hormone; LH-Releasing Hormone; LHFSH Releasing Hormone; Light; Luliberin; Luteinizing Hormone-Releasing Factor; Luteinizing Hormone-Releasing Hormone; Luteinizing hormone-releasing factor (pig); Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Mediating; Melatonin; Membrane; Memory; Mental disorders; Mental health disorders; Mice; Modeling; Molecular; Murine; Mus; Mus musculus; Nervous System, Brain; Nucleus; Ovocyclin; Ovocylin; Ovulation; Pathway interactions; Pattern; Peripheral; Peromyscus; Phase; Phosphorylation; Photoperiod; Photoradiation; Process; Progynon; Protein Phosphorylation; Protein Synthesis Antagonists; Protein Synthesis Inhibitors; Psychiatric Disease; Psychiatric Disorder; Psychosis, Manic-Depressive; Pulsti; RNA Expression; Receptor Protein; Receptor Signaling; Recombinant Gonadorelin; Regulation; Reproduction; Research; Research Personnel; Researchers; Schizophrenia; Schizophrenic Disorders; Signal Pathway; Social Interaction; Stream; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic GRH; Therapeutic Hormone; Therapeutic Steroid Hormone; Threonine/Tyrosine Protein Kinase; Time; Transcription; Transcription, Genetic; Unspecified Mental Disorder; Western Blotting; Western Blottings; Western Immunoblotting; Woman; base; bipolar affective disorder; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; clinical investigation; dementia praecox; dimer; driving; environment effect on gene; extracellular signal related kinase; follicle stimulating hormone-releasing factor; gene environment interaction; gonadotropin releasing factor; hippocampal; hypothalamic; insight; male; manic depressive disorder; manic depressive illness; membrane structure; men; men's; mental illness; non-genomic; nongenomic; pathway; protein blotting; psychological disorder; public health relevance; receptor; response; schizophrenic; steroid hormone",Environmental regulation of estrogen dependent aggression,"  Estrogens affect a wide variety of processes in the brain and many aspects of behavior including social interactions, reproduction, and memory. The amount of light a male California mouse is exposed to each day determines whether estrogens increase or decrease aggression. The proposed research will investigate the cellular mechanisms that underlie this gene-environment interaction that affects a behavior associated with many mental disorders.",85069,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",A2,1,323197,
7786036,R01,MH,1,,02/01/2010,11/30/2010,PA-08-089,1R01MH085132-01A2,,NIMH:727862;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,14,075239632,US,NY,10029,NEW YORK ACADEMY OF MEDICINE,"BEARD, JOHN ;",8545196;,1R01MH085132,02/01/2010,11/30/2014,"Accounting; Affect; Age; Age-Years; Aged 65 and Over; Area; Behavior; Characteristics; Cities; Clinical Research; Clinical Study; Communities; Complex; Data Banks; Data Bases; Data Sources; Databank, Electronic; Databanks; Database, Electronic; Databases; Depression; Development; Digit; Digit structure; Dimensions; Disadvantaged; Disease; Disorder; Effects, Longterm; Elderly; Elderly, over 65; Emotional Depression; Environment; Environmental Factor; Environmental Risk Factor; Evaluation; Factor Analyses; Factor Analysis; Fostering; Future; General Population; General Public; Health; History; Individual; Infrastructure; Intervention; Intervention Strategies; Interview; Investigators; Investments; Life; Long-Term Effects; Longitudinal Studies; Measures; Mental Depression; Mental Health; Mental Hygiene; Methods; Modification; Nature; Neighborhoods; New York City; Outcome; Participant; Pattern; Perception; Personal Satisfaction; Phone; Physical activity; Policies; Programs (PT); Programs [Publication Type]; Psychological Health; Randomized; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Researchers; Risk; Safety; Sampling; Services; Site; Sources, Data; Statistical Methods; Symptoms; Symptoms of depression; Telephone; Testing; Time; Transportation; Visual; advanced age; aged; base; clinical data repository; clinical data warehouse; cohort; community safety; data repository; depressive; depressive symptoms; design; designing; disease/disorder; elders; environmental intervention; environmental risk; evidence base; geriatric; healthy aging; improved; innovate; innovation; innovative; instrument; intervention design; interventional strategy; late life; later life; long-term study; member; neighborhood safety; novel; older adult; older person; pedestrian safety; physical conditioning; population based; population survey; programs; public health relevance; randomisation; randomization; randomly assigned; recruit; relational database; residence; senior citizen; social; theories; therapy design; treatment design; well-being","Risk for Depression, Neighborhood Characteristics, and Physical Activity"," Narrative The proposed study will fill major gaps in our understanding of the relationship between physical activity and depression in older adults. It will also explore how the environment in which an older person lives may influence both these outcomes. Finally, it will test the influence of environmental factors on the health of older adults by evaluating the impact on participants of a major environmental intervention that will be undertaken in the study area. Characterizing these relationships has many potential benefits, and will provide evidence on which to base the development of individual and neighborhood level interventions to foster healthy aging.",85132,CIHB,Community Influences on Health Behavior,A2,1,727862,
7783980,R01,MH,1,,01/06/2010,12/31/2010,PA-07-070,1R01MH085974-01A1,,NIMH:378710;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,NEUROLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"CARTER, ADAM GEORGE;",9064651;,1R01MH085974,01/06/2010,12/31/2014,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Action Potentials; Addiction, Drug; Animals; Area; Back; Behavior; Blood Coagulation Factor IV; Brain; Brain region; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Ion Signaling; Calcium Signaling; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Chemical Dependence; Coagulation Factor IV; Cognition; Complex; D(2C) Dopamine Receptor; D(4) Dopamine Receptor; D4DR; DRD4; DRD4 Protein; DRD4 protein, human; Dendrites; Dendritic Spines; Dependence, Drug; Disease; Disease Attributes; Disorder; Dopamine; Dopamine Receptor; Dopamine Receptor D4; Dorsum; Drug Addiction; Drug Dependency; Dysfunction; Electromagnetic, Laser; Emotional; Emotions; Encephalon; Encephalons; Event; Factor IV; Functional disorder; Gene Expression; Glutamate Receptor; Glutamates; Goals; Human; Human, General; Hydroxytyramine; Image; Individual; Intracellular Communication and Signaling; Ion Channel; Ion Channels, Calcium; Ionic Channels; Kinetic; Kinetics; L-Glutamate; Laser Scanning Microscopy; Lasers; Location; Magnesium; Mammals, Mice; Mammals, Primates; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Channels; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mg element; Mice; Microscopy; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Na element; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Pattern; Pharmacology; Photons; Physiologic; Physiological; Physiology; Physiopathology; Play; Prefrontal Cortex; Primates; Property; Property, LOINC Axis 2; Pyramidal neuron; Radiation, Laser; Receptor Activation; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, N-Methylaspartate; Rodent; Rodentia; Rodentias; Role; Scanning Microscopy, Laser; Schizophrenia; Schizophrenic Disorders; Shapes; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Sodium; Spinal Column; Spine; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Technology; Testing; V (voltage); VDCC; Ventral Tegmental Area; Vertebral column; Voltage-Dependent Calcium Channels; backbone; biological signal transduction; cell body (neuron); cognitive control; dementia praecox; dendrite spine; disease/disorder; dopamine D4 receptor; dopamine receptor D4 protein, human; excitatory neuron; experiment; experimental research; experimental study; hippocampal pyramidal neuron; human DRD4 protein; human disease; imaging; membrane structure; nervous system disorder; neural cell body; neurological disease; neuronal; neuronal cell body; new therapeutic target; novel; pathophysiology; public health relevance; receptor; research study; response; schizophrenic; social role; soma; ventral tegmentum; voltage; working memory",Dendritic physiology and calcium signaling in pyramidal neurons of the prefrontal," Project Narrative The prefrontal cortex is important for controlling cognition, emotion and memory in animals ranging from mice to humans. The importance of the prefrontal cortex is highlighted in multiple neurological diseases, including schizophrenia and drug addiction. The proposed experiments will determine how these neurons function and identify novel treatments for these and other debilitating neurological diseases.",85974,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",A1,1,378710,
7791121,R01,MH,1,,01/06/2010,12/31/2010,PA-07-070,1R01MH086518-01A1,,NIMH:409000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,WALTHAM,UNITED STATES,BIOLOGY,07,616845814,US,MA,024549110,BRANDEIS UNIVERSITY,"LISMAN, JOHN E;",1883885;,1R01MH086518,01/06/2010,12/31/2014,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Address; Affect; Ammon Horn; Animal Model; Animal Models and Related Studies; Anterior; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Attention; Behavior; Behavioral; Biological Models; CRE Recombinase; Cell Nucleus; Cells; Characteristics; Chronic; Cognitive Discrimination; Common Rat Strains; Cornu Ammonis; Cre recombinase, Enterobacteria phage P1; Delta Wave; Delta Wave sleep; Discrimination; Discrimination (Psychology); Disease; Disorder; Dopamine; Drug Therapy; Drugs; EEG; Electroencephalography; Enterobacteria phage P1 Cre recombinase; Frequencies (time pattern); Frequency; Genetics, in situ Hybridization; Glutamates; Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Hydroxytyramine; In Situ Hybridization; In Vitro; Injection of therapeutic agent; Injections; Investigation; Knock-out; Knockout; L-Glutamate; Major Tranquilizers; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Medication; Membrane Potentials; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods; Mice; Model System; Modeling; Models, Biologic; Molecular; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Nucleus; Occipital lobe; Pace Stimulators; Pacemakers; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phenotype; Prefrontal Cortex; Process; Property; Property, LOINC Axis 2; Rat; Rattus; Receptors, N-Methylaspartate; Resting Potentials; Role; Schizophrenia; Schizophrenic Disorders; Short-Term Memory; Sight; Slow-Wave Sleep; Stimulators, Electrical, Pace; Survey Instrument; Surveys; Symptoms; System; System, LOINC Axis 4; Testing; Thalamic Nuclei; Thalamic structure; Thalamus; Tranquilizing Agents, Major; Transmembrane Potentials; Vision; Visual; Wakefulness; Wakefulnesses; Work; awake; bacteriophage P1 recombinase Cre; base; dementia praecox; disease/disorder; dopamine system; drug/agent; experiment; experimental research; experimental study; hippocampal; in situ Hybridization Staining Method; in vivo; information processing; insight; model organism; new therapeutics; next generation therapeutics; novel therapeutics; nucleus reticularis; occipital cortex; prepulse inhibition; public health relevance; research study; response; schizophrenic; social role; thalamic; therapeutic target; working memory",Role of NMDA receptors in awake-state thalamocortical slow waves," Public Health Relevance Statement According to the dysrhythmia hypothesis of schizophrenia, the enhanced low frequency thalamocortical oscillation found in the disease causes many of the symptoms. The cellular and molecular causes of this dysrhythmia in the thalamus will be investigated. A major clue appears to be the ability of NMDA recent antagonists to mimic the dysrhythmia.",86518,ZRG1,Special Emphasis Panel,A1,1,409000,
7767451,R01,MH,1,,01/06/2010,11/30/2010,PA-07-070,1R01MH087610-01,,NIMH:306614;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DURHAM,UNITED STATES,OTHER BASIC SCIENCES,04,044387793,US,NC,27705,DUKE UNIVERSITY,"EGNER, TOBIAS ;",8969908;,1R01MH087610,01/06/2010,11/30/2012,"Address; Animals; Architecture; Attention; Bears; Behavior; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Collaborations; Collection; Complex; Conflict; Conflict (Psychology); Cues; Detection; Encephalon; Encephalons; Engineering / Architecture; Ensure; Event; FLR; Failure (biologic function); Forms Controls; Functional Magnetic Resonance Imaging; Goals; Heart; Human; Human, General; Intracellular Communication and Signaling; Investigators; Knowledge; Label; Learning; Left; Literature; Locomotor Activity; MRI, Functional; Magnetic Resonance Imaging, Functional; Maintenance; Maintenances; Mammals, Primates; Man (Taxonomy); Man, Modern; Measurement; Mediating; Methods and Techniques; Methods, Other; Modeling; Monitor; Motor Activity; Nature; Nervous; Nervous System Diseases; Nervous System, Brain; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurosciences; Play; Position; Positioning Attribute; Primates; Process; Programs (PT); Programs [Publication Type]; Psychological reinforcement; Recruitment Activity; Reinforcement; Reinforcement (Psychology); Research; Research Personnel; Research Resources; Researchers; Resources; Role; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stimulus; Substrate Interaction; System; System, LOINC Axis 4; Taxes; Techniques; Testing; Time; Transcranial magnetic stimulation; Ursidae; Ursidae Family; Work; base; biological signal transduction; clinical relevance; clinically relevant; cognitive control; design; designing; expectation; fMRI; failure; flexibility; improved; nervous system disorder; neural; neural mechanism; neuroimaging; neurological disease; neuromechanism; programs; public health relevance; recruit; relating to nervous system; repetitive transcranial magnetic stimulation; response; social role",Characterizing neural mechanisms of cognitive control," Project Narrative The proposed research is designed to elucidate neural mechanisms of 'cognitive control', the ability to generate, maintain, and adjust sets of goal-directed processing strategies, which lies at the heart of the type of flexible behavior that distinguishes humans from other animals, including other primates. We pursue this goal by combining experimental tasks that tax various component processes of cognitive control to differing degrees with measurements of brain activity (and functional connectivity between brain regions), as well as with stimulation techniques that temporarily inhibit function in a specific brain region, so that we can pinpoint which aspect of cognitive control is mediated by which brain region (or which set of interacting brain regions). The knowledge gained from this work will enhance our understanding of how the healthy brain mediates flexible, goal-directed behavior, and will provide more precise ideas of how neural mechanisms of cognitive control might be disrupted in psychiatric and neurological conditions.",87610,COG,Cognitive Neuroscience Study Section,,1,306614,
7767107,R01,MH,1,,01/06/2010,12/31/2010,PAR-07-048,1R01MH087758-01,,NIMH:369009;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"RAYPORT, STEPHEN ;",1884462;,1R01MH087758,01/06/2010,12/31/2014,"(Methyl-ONN-azoxy)methanol Acetate; 21+ years old; Acute; Address; Adult; Affect; Agonist; Alleles; Allelomorphs; Ammon Horn; Apoplexy; Attenuated; Behavioral; Birth; Body Tissues; Breast Cell Glutaminase; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Clinical; Clinical Drug Development; Clinical Trials; Clinical Trials, Unspecified; Cornu Ammonis; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Development Plans; Drug Development, Clinical; Drug Testing/Development, Clinical; Drug Therapy; Drugs; Dysfunction; EC 3.5.1.2; Early treatment; Embryo; Embryonic; Functional Imaging; Functional disorder; GA Protein; GLS2; Genetic; Glutamates; Glutaminase; High Throughput Assay; Hippocampus; Hippocampus (Brain); Human, Adult; Image; Knock-out; Knockout; Knockout Mice; Knowledge; L glutamine amidohydrolase; L-Glutamate; Lead; Liver Glutaminase; Mammals, Mice; Measures; Medication; Methanol, (methyl-ONN-azoxy)-, acetate (ester); Methylazoxymethanol Acetate; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Movement; Murine; Mus; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neural Transmission; Neurochemistry; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuronal Transmission; Neurons; Null Mouse; Parturition; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Phosphate Activated Glutaminase; Physiologic Imaging; Physiopathology; Plans, Development; Proteins; Psychopathology; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Stroke; Synapses; Synaptic; Synaptic Transmission; Testing; Therapeutic; Tissues; Translating; Translatings; Transmission; Vascular Accident, Brain; abnormal psychology; adult human (21+); atypical antipsychotic; base; body movement; brain attack; cerebral vascular accident; clinical applicability; clinical application; clinical investigation; dementia praecox; drug candidate; drug development; drug/agent; endophenotype; excitotoxicity; gene product; heavy metal Pb; heavy metal lead; high throughput screening; hippocampal; imaging; inhibitor; inhibitor/antagonist; insight; intervention effect; language translation; neurochemistry; neurodegenerative illness; neuronal; neurotransmission; novel; pathophysiology; preclinical study; presynaptic; public health relevance; resilience; schizophrenic; small molecule; stroke; synapse inhibition; synaptic inhibition; transmission process",Therapeutic potential of GLS1 inhibition for the pharmacotherapy of schizophrenia," We have recently generated a coherent set of clinical and basic findings raising the hypothesis that pharmacological inhibition of phosphate-activated glutaminase, the product of gene GLS1, should prove therapeutic in schizophrenia. We propose to test this hypothesis using GLS1- deficient mice as a proof of concept. The aims are to gain insight into the therapeutic basis for GLS1 inhibition, to elucidate the circuitry involved, and to gain the necessary knowledge for moving toward clinical drug development.",87758,ZRG1,Special Emphasis Panel,,1,369009,
7865574,R01,MH,1,,02/01/2010,01/31/2011,PA-07-070,1R01MH090173-01,,NIMH:423998;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHARLESTON,UNITED STATES,PSYCHIATRY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SWEAT, MICHAEL D;",2024564;,1R01MH090173,02/01/2010,01/31/2015,"AIDS; AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV prevention; AIDS/HIV test; Abstinence; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Analysis, Data; Anti-Retroviral Agents; Antiretroviral Agents; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Caring; Case Study; Clinical Trial Overviews; Cognitive; Collaborations; Communities; Conditioning Therapy; Condom; Condoms, Unspecified; Consensus; Counseling; Data; Data Analyses; Data Pooling; Data Poolings; Department of Health and Human Services; Department of Health and Human Services (U.S.); Developing Countries; Developing Nations; Diffusion; Drugs; Economic Income; Economical Income; Education; Educational aspects; Effectiveness; Emergencies; Emergency Situation; Environment; Evaluation; Family; Family Planning; Family Planning Services; Funding; Funding Agency; Funding Source; Generalized Growth; Generations; Goals; Government; Growth; HHS; HIV; HIV Prevention; HIV test; HIV/AIDS prevention; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Immunologic Deficiency Syndrome, Acquired; Income; Individual; Intervention; Intervention Strategies; Interview; Investigators; LAV-HTLV-III; Less-Developed Countries; Less-Developed Nations; Life; Life Style Modification; Literature; Lymphadenopathy-Associated Virus; Mass Media; Math Models; Medical; Medication; Meta-Analyses; Meta-Analysis; Needles; Outcome; PROV; Partner Notification; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Phone; Policies; Pressure; Pressure- physical agent; Prevention; Prevention program; Prevention strategy; Preventive strategy; Principal Investigator; Programs (PT); Programs [Publication Type]; Provider; Psychosocial Assessment and Care; Publishing; Relative; Relative (related person); Reporting; Research Personnel; Research Resources; Researchers; Resources; Review Literature; Risk Behaviors; Risky Behavior; Schools; Sex Education; Social Marketing; South Carolina; Syringes; Telephone; Terminology; Testing; Third-World Countries; Third-World Nations; Tissue Growth; Treatment Efficacy; Typology; Under-Developed Countries; Under-Developed Nations; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Universities; Update; Vertical Disease Transmission; Vertical Transmission; Virus-HIV; WHO; Woman; Work; World Health Organization; anti-retroviral; antiretroviral; at risk behavior; base; behavior intervention; behavioral intervention; case report; comparative effectiveness; condoms; drug/agent; empowerment; evidence base; experience; improved; interest; intervention design; interventional strategy; mass information media; mathematical model; mathematical modeling; meetings; mother to child transmission; ontogeny; peer; pressure; programs; psychosocial assessment; psychosocial care; psychosocial studies; psychosocial support; public health relevance; skills training; social capital; systematic review; therapeutic efficacy; therapeutically effective; therapy design; treatment design; uptake",Synthesizing HIV Behavioral Intervention Effectiveness in Developing Countries," PROJECT NARRATIVE With the dramatic growth in funding for HIV behavioral interventions in developing countries there are multiple initiatives to better allocate of these funds based on evidenced-based standards. Comparative effectiveness studies have been requested by multiple donors and agencies to meet this need. This requires up to date systematic reviews and meta-analyses, as well as careful evaluation of the content of interventions. These will result in improved understanding of which intervention components are proven to be most efficacious, and will advance the field in establishing clear intervention terminology and theoretical constructs. The goal of this study is to provide needed policy and program advice on what is working in HIV prevention based on the strength of evidence from the scientific literature.",90173,ZRG1,Special Emphasis Panel,,1,423998,
7891127,R01,NS,1,,03/01/2010,02/28/2011,PA-07-070,1R01NS049117-01A2,,NINDS:334688;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DAVIS,UNITED STATES,NEUROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"MASELLI, RICARDO ANIBAL;",3095403;,1R01NS049117,03/01/2010,02/28/2015,"21+ years old; Acetyl-CoA[{..}]choline O-acetyltransferase; Acetylcholine Hydrolase; Acetylcholinesterase; Adult; Affect; Agrin; Animal Model; Animal Models and Related Studies; Biological; Biopsy; Blood capillaries; Candidate Disease Gene; Candidate Gene; Capillaries; Capillary; Capillary, Unspecified; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Line; Cell Lines, Strains; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Choline Acetylase; Choline Acetyltransferase; Choline O-Acetyltransferase; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Chromosomal microdeletion; Chromosomal, Gene, or Protein Abnormality; Clinical; Clinical Data; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Code; Coding System; Collagen; Comparative Genome Hybridization; Complex; Congenital Myasthenic Syndromes; Cytogenetic or Molecular Genetic Abnormality; DNA; DNA Resequencing; DNA Sequence; DNA analysis; Defect; Deoxyribonucleic Acid; Detection; Disease; Disorder; EC 2.7; Electrodes, Miniaturized; Electron Microscopy; Elements; Enzymes; Evaluation; FLR; Failure (biologic function); Gene Products, RNA; Genealogic Tree; Genealogical Tree; Genes; Genetic Abnormality; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Glycoprotein GP-2; Goals; Hereditary; History; Human, Adult; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Inherited; Intercostal Muscles; Ion Channels, Sodium; Kinases; Knowledge; Laboratory Study; Laminin; Lead; Life; Mammalian Cell; Medical Inspection; Membrane; Methods; Methods and Techniques; Methods, Other; Microelectrodes; Mind; Missense Mutation; Modality; Molecular Abnormality; Molecular Diagnosis; Molecular Target; Muscle; Muscle Tissue; Muscle Weakness; Muscle, Skeletal, Receptor Tyrosine Kinase; Muscle-Specific Kinase; Muscular Weakness; Mutate; Mutation; Mutation, Missense; Myasthenia Gravis, Congenital; Myasthenic Syndromes, Congenital; Myoneural Junction; Nature; Neuromuscular Diseases; Neuromuscular Junction; Pathogenesis; Patients; Pb element; Performance; Phenotype; Phosphotransferases; Physical Examination; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Population Control; Proteins; RAPsyn; RNA; RNA, Non-Polyadenylated; Receptor Protein; Receptor Tyrosine Kinase MuSK; Receptors, ACh; Receptors, Acetylcholine; Recording of previous events; Reporting; Research; Resequencing; Ribonucleic Acid; SNP; SNPs; Single Nucleotide Polymorphism; Sodium Channel; Splice-Junction Mutation; Splice-Site Mutation; Structure of intercostal muscle; Syndrome; System; System, LOINC Axis 4; Tail; Techniques; Testing; Time; Transmission; Transphosphorylases; Trees, Family; V (voltage); acetylcholine acetylhydrolase; acetylcholine receptor-associated protein 43K; adult human (21+); alpha Bungarotoxin; association test; capillary; choline esterase I; clinical phenotype; clinical test; comparative genomic hybridization; cultured cell line; disease/disorder; effective therapy; failure; fetal; gene product; genetic association; genome mutation; heavy metal Pb; heavy metal lead; membrane structure; microdeletion; model organism; mutant; myoneural disorder; neuromuscular disorder; neuromuscular transmission; new technology; novel; peripheral membrane protein 43K; polymorphism; postsynaptic protein 43K; prevent; preventing; protein function; public health relevance; receptor; research clinical testing; response; transmission process; voltage",Congenital Myasthenic Syndromes:  Pathogenic Mechanisms," Narrative This project will study a rare form of hereditary neuromuscular disorders, congenital myasthenic syndromes (CMS). Current understanding of these diseases is incomplete, and for many forms of CMS the underlying genetic defects are unknown. The proposed research will investigate the feasibility of applying novel techniques of identification of complex genetic defects causing CMS to determine the underlying cause and resulting effects of those forms of CNS for which no genetic association has been made, thereby bringing us closer to treatments for a large group of afflicted patients for whom there is currently no effective treatment.",49117,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,A2,1,334688,
7780266,R01,NS,1,,01/15/2010,12/31/2010,PA-07-070,1R01NS057670-01A1,,NINDS:261498;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,NEUROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"SEGAL, BENJAMIN MATTHEW;",6481094;,1R01NS057670,01/15/2010,12/31/2014,"A5 Antigen; APC; Acute; Address; Adhesion Molecule; Animal Model; Animal Models and Related Studies; Animals; Animals, Laboratory; Antigen-Presenting Cells; Apoptosis; Apoptosis Pathway; Autoimmune; Autoimmune Process; Autoimmune Responses; Autoimmune Status; Autoimmunity; Automobile Driving; Blood; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood monocyte; Bone Marrow; Bp50; CD106; CD106 Antigens; CD11b; CD11c; CD154; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD40; CD40L; CD40LG; CD54 (ICAM 1); CD54 Antigens; CDW40; CR3A; CSF3; CSF3 gene; CXCL12; CXCL12 gene; Cell Adhesion Molecules; Cell Communication; Cell Communication and Signaling; Cell Components; Cell Death, Programmed; Cell Interaction; Cell Signaling; Cell Structure; Cell surface; Cell-to-Cell Interaction; Cells; Cells, CD4; Cellular Structures; Central Nervous System; Characteristics; Chemokine (C-C motif) Ligand 3; Clinical; Cytokines, Chemotactic; DIF; Data; Demyelinating Diseases; Demyelinating Disorders; Demyelinations; Dendritic Cells; Development; Disease; Disease remission; Disorder; Drivings, Automobile; EAE; Effector Cell; Encephalomyelitis; Encephalomyelitis, Allergic; Esteroproteases; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; G-CSF; GCSF; GM-CSF; GMCSF; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Glia; Glial Cells; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic; Heterophil Granulocyte; Histamine-Producing Cell-Stimulating Factor; Homologous Chemotactic Cytokines; ICAM-1; INCAM-110; ITGAM; ITGAM gene; ITGAX; ITGAX gene; ITX; Immunologic Accessory Cells; Immunologically Directed Therapy; Immunotherapy; In Situ; Inducible Cell Adhesion Molecule 110; Inflammatory; Inflammatory Infiltrate; Intercellular adhesion molecule 1; Intercrines; Interruption; Intracellular Communication and Signaling; Kolliker's reticulum; LTA; Laboratory Animals; Lead; Lymphotoxin; Lymphotoxin A; Lymphotoxin-alpha; MAC-1; MAC1A; MGC45931; MGC9013; MHC Class II; MHC Class II Genes; MIP 1alpha; MIP-1 Alpha; MIP-1a; MO1A; MS (Multiple Sclerosis); Marrow Neutrophil; Marrow monocyte; Mediating; Modeling; Molecular; Molgramostin; Monocytes / Macrophages / APC; Multiple Sclerosis; Myelin; Myeloencephalitis; Myelogenous; Myeloid; Myeloid Cells; Myeloid Progenitor Cells; NRP; NRP1; NRP1 Protein; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neuropilin-1; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Non-neuronal cell; Npn-1 Protein; ODF; OPGL; PBSF; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Peripheral; Phenotype; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteolytic Enzymes; RANKL; RMSN; Recovery; Regulation; Regulatory T-Lymphocyte; Relapse; Remission; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Role; SCYB12; SDF-1A; SDF-1B; SDF1; SDF1A; SDF1B; SIS cytokines; Sclerosis, Disseminated; Sema III Receptor; Semaphorin III Receptor; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A3; Source; Staging; Stem Cell Inhibitor; Stem Cells, Myeloid; Stromal Cells; Suppressor Cells; Suppressor-Effector T-Lymphocytes; T Suppressor Cell; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Suppressor-Effector; T4 Cells; T4 Lymphocytes; TC-GM-CSF; TLSF-A; TLSF-B; TNF; TNF A; TNF Superfamily, Member 1; TNF gene; TNF-b; TNF-beta; TNFRSF5; TNFRSF5 gene; TNFSF1; TNFSF11; TNFSF11 gene; TNFSF2; TNFSF5; TNFSF5 gene; TPAR1; TRAP Gene; Testing; Thymus-Dependent Lymphocytes; Tumor Cell; Tumor Necrosis Factor Gene; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Tumor Necrosis Factor-Beta; Tumor-Cell Human GM Colony-Stimulating Factor; VCAM; VCAM-1; VEGF165R; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Cell Growth Factor 165 Receptor; Veiled Cells; Work; accessory cell; anergy; autoimmune encephalomyelitis; base; biological signal transduction; biomarker; cell adhesion protein; chemoattractant cytokine; chemokine; cytokine; disability; disease/disorder; driving; exhaust; experiment; experimental research; experimental study; granulocyte macrophage colony stimulating factor; hRANKL2; heavy metal Pb; heavy metal lead; helper T cell; immune therapy; insight; insular sclerosis; macrophage; model organism; monocyte; neoplastic cell; nerve cement; neuroinflammation; neuronal; neutrophil; new therapeutic target; novel; p50; pathway; pre-clinical; preclinical; precursor cell; prevent; preventing; public health relevance; research study; response; sOdf; self recognition (immune); social role; suppressor T lymphocyte; therapeutic target; thymus derived lymphocyte",The regulation of myeloid cell development and mobilization during autoimmune dem," Project Narrative Although recent advancements in the immunotherapy of multiple sclerosis (MS) have focused on the T cell component of the autoimmune response, myeloid cells (including macrophages and dendritic cells) compose the majority of CNS-infiltrating cells in MS and its model, experimental autoimmune encephalomyelitis (EAE), and mediate direct damage to neurons and glia. The purpose of this proposal is to elucidate the cytokine pathways and molecular mechanisms that underlie the mobilization of myeloid cells from the bone marrow and that drive their differentiation into pathogenic effector cells during autoimmune demyelinating disease. It is anticipated that our results will lead to the discovery of novel biomarkers and therapeutic targets related to myeloid cell dysregulation in MS.",57670,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,A1,1,261498,
7777203,R01,NS,1,,01/15/2010,12/31/2010,PA-08-097,1R01NS060125-01A2,,NINDS:332228;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DAVIS,UNITED STATES,NEUROSCIENCES,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"MCALLISTER, A KIMBERLEY;",1926705;,1R01NS060125,01/15/2010,12/31/2013,"21+ years old; Address; Adult; Age; Assay; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological Assay; Body Tissues; Brain; Cell/Tissue, Immunohistochemistry; Cells; Central Nervous System; Chemistry, Biological; Cytotoxic cell; Development; Disease; Disorder; Electron Microscopy; Encephalon; Encephalons; Family; Glutamates; Goals; Histocompatibility Complex; Histocompatibility Complices; Histocytochemistry; Human; Human, Adult; Human, General; IHC; Image; Immune; Immune Function, Cellular; Immune Globulins; Immune response; Immune system; Immunoelectron Microscopy; Immunoglobulins; Immunoglobulins / Antibodies; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Receptors; Immunological Receptors; In Vitro; K lymphocyte; KIR receptor; KLRA1; KLRA1 gene; Kanner's Syndrome; Knock-out; Knockout; Knockout Mice; L-Glutamate; LY49; LY49L; Label; Location; Major Histocompatibility Complex; Major Histocompatibility Complices; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Knock-out; Mice, Knockout; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Molecular; Molecular Interaction; NK Cells; NRVS-SYS; Natural Killer Cells; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurocyte; Neurodevelopmental Disorder; Neurologic Body System; Neurologic Organ System; Neurological Development Disorder; Neurons; Null Mouse; Pathogenesis; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Receptor Signaling; Receptors, Immunologic; Role; Schizophrenia; Schizophrenic Disorders; Sequence-Specific Posttranscriptional Gene Silencing; Slice; Staging; Stimulus; Synapses; Synaptic; Testing; Time; Tissues; Transfection; adult human (21+); base; body system, allergic/immunologic; critical period; dementia praecox; density; disease/disorder; gene product; histochemistry; histochemistry/cytochemistry; host response; imaging; immune function; immune receptor; immunocytochemistry; immunoresponse; in vivo; killer inhibitory receptor; nervous system development; neuronal; novel; organ system, allergic/immunologic; overexpression; p58 NK cell inhibitory receptor; patch clamp; postnatal; postsynaptic; presynaptic; public health relevance; receptor; schizophrenic; social role; synapse formation; synapse function; synaptic function; synaptogenesis",Immune molecules in early postnatal nervous system development," Project Narrative  Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of neurodevelopmental disorders including autism and schizophrenia, many of these stimuli have in common the ability to alter immune function. Since MHCI molecules initiate and mediate the immune response 9 and are present in the brain 10, it is entirely possible that changes in expression of MHCI in the developing brain caused by environmental insults contribute to the cellular changes that cause these disorders. The central goal of this proposal is to determine the function of MHCI proteins during the initial formation of connections in the early postnatal brain, a comparable developmental stage to the time of the immune challenge proposed to predispose humans toward neurodevelopmental disorders.",60125,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",A2,1,332228,
7892721,R01,NS,1,,02/01/2010,01/31/2011,PA-07-303,1R01NS062097-01A2,,NINDS:339063;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,ANESTHESIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"WEI, LING ;",1952752;,1R01NS062097,02/01/2010,01/31/2015,"21+ years old; Address; Adult; Angiogenic Factor; Animals; Antibodies; Apoplexy; Assay; Autograft; Autologous Transplantation; Autotransplant; Behavior; Bioassay; Biologic Assays; Biological Assay; Blood; Blood - brain barrier anatomy; Blood-Brain Barrier; Blotting, Western; Bone Marrow; Bone Marrow Stem Cell; Bone Marrow Transplant; Bone Marrow Transplantation; Brain; Brain region; CNS Diseases; CNS disorder; Cardiovascular Surgical Procedures; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cells; Central Nervous System Diseases; Central Nervous System Disorders; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Chest; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Data; ELISA; Editorial; Editorial (PT); Editorial Comment; Editorial Comment (PT); Editorial [Publication Type]; Effectiveness; Encephalon; Encephalons; Environment; Enzyme-Linked Immunosorbent Assay; Ethical Issues; Exhibits; Exposure to; Factor, Angiogenesis; Future; Goals; Graft Rejection; Graft Survival; Grafting, Bone Marrow; Grant; Hemato-Encephalic Barrier; Home; Home environment; Homing; Human, Adult; Hypoxia; Hypoxic; In Vitro; Intracellular Communication and Signaling; Investigation; Investigators; Ischemia; Ischemic Stroke; Issues, Ethical; Journals; MSC transplantation; Magazine; Mammals, Rats; Marrow Transplantation; Mesenchymal Progenitor Cell; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Modeling; Mortality; Mortality Vital Statistics; Mother Cells; Neonatal; Nervous; Nervous System, Brain; Neural Growth; Neurologic; Neurological; Neuronal Growth; Outcome; Oxygen Deficiency; Paper; Pathway interactions; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Process; Progenitor Cell Transplantation; Progenitor Cells; Published Comment; Publishing; Rat; Rattus; Recovery; Recovery of Function; Research; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Sensorimotor functions; Signal Transduction; Signal Transduction Systems; Signaling; Staining method; Stainings; Stains; Stem Cell Transplantation; Stem cell transplant; Stem cells; Stroke; Survival Rate; Testing; Therapeutic; Thorace; Thoracic; Thorax; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation, Autologous; VEGFs; Vascular Accident, Brain; Vascular Endothelial Growth Factors; Vascularization; Vegf; Vibrissae; Viewpoint; Viewpoint (PT); Western Blotting; Western Blottings; Western Immunoblotting; Whiskers; Work; Wound Healing; Wound Repair; Writing; adult animal; adult human (21+); angiogenesis; barrel cortex; biological signal transduction; brain attack; cardiovascular surgery; cell type; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; editorial; effective therapy; function improvement; functional improvement; functional recovery; improved; in vivo; mature animal; necrocytosis; neonatal human; neonate; neural; neurogenesis; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; optic imaging; optical imaging; pathway; preconditioning; protein blotting; public health relevance; regenerative; relating to nervous system; repair; repaired; response; stroke; stroke therapy; tissue repair; transplant",Transplantation of Pre-conditioned Bone Marrow Mesenchymal Stem Cells after Ische,  A combination strategy will be tested to improve the cell survival quality and regenerative capacities of transplanted bone marrow mesenchymal stem cells (BMSCs) after rat neonatal ischemic stroke. We will address three key issues in BMSC transplantation: 1) to promote survival of BMSCs after transplantation; 2) to promote endogenous regenerative responses; 3) to guide and improve the repair process and functional recovery in the whisker-barrel pathway after BMSC transplantation.,62097,DBD,Developmental Brain Disorders Study Section,A2,1,339063,
7785009,R01,NS,1,,01/18/2010,11/30/2010,PA-07-070,1R01NS062182-01A2,,NINDS:322745;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,RALEIGH,UNITED STATES,VETERINARY SCIENCES,04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"GHASHGHAEI, HOOMAN TROY;",7796766;,1R01NS062182,01/18/2010,11/30/2013,"21+ years old; Address; Adult; Aging; Anterior; Astrocytes; Astrocytus; Astroglia; Autoregulation; Birth; Birth Defects; Brain; Brain region; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Therapy; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cerebral cortex; Characteristics; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Connector Neuron; Data; Development; ES cell; Embryo; Embryonic; Encephalon; Encephalons; Ependymal Cell; Ependymocyte; Exhibits; Fore-Brain; Forebrain; Future; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Generations; Genes; Genetic; Glia; Glial Cells; Goals; Harvest; Head; Homeostasis; Human, Adult; Hydrocephalus; Hydrocephaly; In Vitro; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Knockout Mice; Kolliker's reticulum; Lateral; Lateral Ventricle of Brain; Lateral Ventricles; Lateral ventricle structure; Life; Light; Mediating; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Genetic Abnormality; Mother Cells; Myxoid cyst; Neostriatum; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Ganglion; Neural Growth; Neural Stem Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neuronal Growth; Neurons; Non-neuronal cell; Null Mouse; Olfactory Bulb; Parturition; Photoradiation; Physiological Homeostasis; Population; Production; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prosencephalon; Radial; Regulation; Role; Senescence; Specific qualifier value; Specified; Stem cells; Stream; Structure; Structure of olfactory bulb; Subcellular Process; Surface; Testing; Therapy, Cell; Time; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Ventricular; adult human (21+); adult neurogenesis; adult stem cell; base; cell type; cell-based therapy; cellular development; cultured cell line; embryonic stem cell; fork head protein; forkhead protein; forkhead transcription factors; interest; lateral ventricle; loss of function; migration; nerve cement; nerve stem cell; neural progenitor cells; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; novel; olfactory bulb; postnatal; prenatal; progenitor; public health relevance; senescent; social role; stem cell niche; stem cell of embryonic origin; subventricular zone; tool; transcription factor; unborn",Transcriptional regulation of aging in the adult neural stem cell niche, PROJECT NARRATIVE Our proposed studies will determine novel regulatory mechanisms of a gene that drives the development of a cellular niche for postnatal and adult neural stem cells. Delineation of mechanisms that regulate persistence of regionally specific neurogenesis in the postnatal and adult brain is critical to future application of adult neural stem cells in cell-based therapies.,62182,NCF,Neurogenesis and Cell Fate Study Section,A2,1,322745,
7792679,R01,NS,1,,02/01/2010,01/31/2011,PAS-08-048,1R01NS062219-01A2,,NINDS:364327;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"JOHNSON, MARK D;",1911227;,1R01NS062219,02/01/2010,01/31/2015,"ATP[{..}]myosin-light-chain O-phosphotransferase; Abscission; Actins; Adhesion Plaques; Antimorphic mutation; Area; Assay; Astrocytoma, Grade IV; Bioassay; Biologic Assays; Biological Assay; Brain; CCND1 Protein; CDI1 Protein; CDK; CDK2-Associated Dual Specificity Phosphatase; CDKN3 Protein; CIP2 Protein; Cancer stem cell; Cell Locomotion; Cell Migration; Cell Movement; Cell-Matrix Adherens Junctions; Cells; Cellular Migration; Clinical Trials; Clinical Trials, Unspecified; Cyclin D1; Cyclin-Dependent Kinase Inhibitor 3; Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase); Cyclin-Dependent Kinase Interacting Protein 2; Cyclin-Dependent Kinase Interactor 1; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; EC 2.7.1.117; Encephalon; Encephalons; Excision; Extirpation; FADK; FAK; FAK1; Focal Adhesions; Focal Contacts; G1/S-Specific Cyclin D1; Gene Transcription; Genetic Transcription; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Human; Human, General; In Vitro; KAP Protein; KAP1 Protein; Kinase-Associated Phosphatase; Kinases; Lesion; Life; MLCK; MYLK; MYLK2; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Micro-tubule; Microtubules; Modeling; Motility; Motility, Cellular; Murine; Mus; Myosin Kinase; Myosin LCK; Myosin Light Chain Kinase; Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes; Myosin Light Chains; Myosin Light Polypeptide Kinase; Myosin Regulatory Light-Chain Kinase; Myosin light chain kinase 2, skeletal/cardiac muscle; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PRAD1 Protein; PTK2; PTK2 gene; Pathway interactions; Patients; Peripheral; Phosphorylation; Phosphotransferases; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-1; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA Splicing; RNA, Messenger; RNA, Small Interfering; RNAi; Recurrence; Recurrent; Removal; Rho-associated kinase; Rho-kinase; Role; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Splicing; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Therapeutic; Transcription; Transcription, Genetic; Transphosphorylases; Transplantation; Tumor Suppressor Proteins; Tumors of Neuroglia; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; c-bcl-1 Proteins; caldesmon; cdk Proteins; cell motility; clinical investigation; cyclin D; experiment; experimental research; experimental study; gene product; glioblastoma multiforme; glioma cell line; in vivo; inhibitor; inhibitor/antagonist; intervention development; kinase inhibitor; mRNA; migration; novel; overexpression; pathway; pp125FAK; prevent; preventing; public health relevance; research study; resection; siRNA; small molecule; smooth muscle myosin light chain kinase; social role; spongioblastoma multiforme; stem; surgery; therapy development; transplant; treatment development; tumor; tumor suppressor",Preventing Glioma Cancer Stem Cell Dispersal Using Cdc2 Kinase Inhibitors," The intracellular mechanisms regulating glioma invasion of the surrounding brain remain poorly understood. We have identified a novel intracellular pathway that regulates glioma migration and involves the cyclin-dependent kinase-associated phosphatase, KAP, Rho kinase and Cdc2 kinase. Dysregulation of this pathway defines a subpopulation of glioblastomas associated with poor patient outcome. This project will examine the downstream effector mechanisms of this KAP/ROCK/Cdc2 invasion pathway in human CD133+ glioblastoma-derived stem-like cells and in established glioma cell lines. The effect of Cdc2 kinase inhibition on glioblastoma dispersal and overall survival will also be determined using a mouse intracranial human glioma transplantation model.",62219,DT,Developmental Therapeutics Study Section,A2,1,364327,
7890244,R01,NS,1,,04/01/2010,03/31/2011,PA-07-070,1R01NS062365-01A2,,NINDS:333594;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"MILLER, STEPHEN D;",1866587;,1R01NS062365,04/01/2010,03/31/2015,"APC; ATGN; Activities of Daily Living; Activities of everyday life; Acute; Animal Model; Animal Models and Related Studies; Antibody Formation; Antibody Production; Antibody Response; Antigen Presentation; Antigen-Presenting Cells; Antigenic Determinants; Antigenic Determinants, Immunodominant; Antigens; Autoimmune; Autoimmune Process; Autoimmune Responses; Autoimmune Status; Autoimmunity; Automobile Driving; Binding Determinants; C57BL/6 Mouse; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CTLA-8; CTLA8; Cells; Cells, CD4; Central Nervous System; Chronic; Chronic Disease; Chronic Illness; Chronic Phase of Disease; Collection; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Demyelinating Diseases; Demyelinating Disorders; Demyelinations; Dendritic Cells; Development; Disease; Disorder; Drivings, Automobile; Epidemiology; Epitopes; Extremities; FLR; Failure (biologic function); Family; Family Picornaviridae; Folch-Lees Protein; Folch-PI Proteolipid Protein; Funding; Future; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Homologous Chemotactic Cytokines; Hortega cell; Human; Human, General; IL-17; IL-17A; IL17; IL17 Protein; IL17A; Immune; Immune response; Immune system; Immunity; Immunodominant Determinants; Immunodominant Domains; Immunodominant Epitopes; Immunodominant Regions; Immunodominant Sites; Immunologic Accessory Cells; Inbred Strains Mice; Individual; Infection; Inflammatory; Inherited Predisposition; Inherited Susceptibility; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Knockout Mice; LYT3; Lead; Lesion; Life; Limb structure; Limbs; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Mice; Mice, Inbred Strains; Mice, Knock-out; Mice, Knockout; Microglia; Molecular Mimicries; Molecular Mimicry; Monocytes / Macrophages / APC; Mononuclear; Mouse Polioviruses; Mouse Strains; Multiple Sclerosis; Murine; Mus; Myelin; Myelin PLP; Myelin Proteolipid Protein; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, CNS; Neuraxis; Non-Trunk; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; PLP; Palsy; Paralysed; Pathogenesis; Pathology; Pattern; Pb element; Phagocytes; Phagocytic Cell; Phase; Picornaviridae; Picornaviruses; Play; Plegia; Polioviruses, Murine; Predisposition; Regulation; Regulatory T-Lymphocyte; Resistance; Role; SIS cytokines; SJL Mouse; SJL/J Mouse; Sclerosis, Disseminated; Secondary to; Spastic; Staging; Superantigens; Supplementation; Susceptibility; T-Cell Activation; T-Cell Proliferation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TMEV; Testing; Theiler Murine Encephalomyelitis Virus; Theiler's Virus; Theiler's encephalomyelitis virus; Thymus-Dependent Lymphocytes; Transgenic Organisms; United States National Institutes of Health; Veiled Cells; Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; accessory cell; amebocyte; antibody biosynthesis; autoreactive T cell; base; bean; body system, allergic/immunologic; chemoattractant cytokine; chemokine; chronic demyelination; chronic disease/disorder; chronic disorder; cytokine; daily living functionality; design; designing; disease/disorder; driving; enteric pathogen; failure; functional ability; functional capacity; genetic etiology; genetic mechanism of disease; genetic vulnerability; gitter cell; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunoglobulin biosynthesis; immunopathology; immunoresponse; insular sclerosis; macrophage; member; mesoglia; microglial cell; microgliocyte; model organism; mouse model; myelin proteolipid; organ system, allergic/immunologic; paralysis; paralytic; pathogen; perivascular glial cell; proteolipid protein of myelin; public health relevance; resistant; response; self recognition (immune); social role; thymus derived lymphocyte; transgenic; treatment strategy; viral infection; viral-induced demyelination; virus development; virus infection; virus-induced demyelination",Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination," Multiple sclerosis (MS) is an autoimmune paralytic disease caused by immune cell-mediated destruction of myelin-producing oligodendrocytes in the central nervous system. Certain forms of MS are suspected to occur as a secondary consequence a virus infection in genetically susceptible individuals. We will employ a mouse model of MS induced by infection with Theiler's murine encephalomyelitis virus to study the role of regulatory T cells in determining genetic susceptibility to disease in different strains of inbred mice, and to determine the role of dendritic cells, specialized antigen presenting cells of the innate immune system, both in inducing virus immunity in the acute stages of the disease and in inducing development of autoimmune T cells making destructive cytokines (IFN-¨ and IL-17) in the chronic phase of disease.",62365,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",A2,1,333594,
7783286,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS062811-01A2,,NINDS:324844;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN ANTONIO,UNITED STATES,PHYSIOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"EATON, BENJAMIN ARTHUR;",9229931;,1R01NS062811,02/01/2010,01/31/2015,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; ALS; Adenosine Triphosphatase, Dynein; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyotrophic Lateral Sclerosis; Assay; Axonal Transport; Axoplasmic Transport; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cellular Assay; Cellular biology; Complex; Cytoplasmic Membrane; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deposit; Deposition; Development; Disease; Disorder; Drosophila; Drosophila genus; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Dysfunction; Enhancers; Event; Family; Flies; Fluorescence; Frontotemporal Dementia; Fruit Fly, Drosophila; Functional disorder; GTP Phosphohydrolases; GTPases; Gehrig's Disease; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic Techniques; Genetic defect; Glues; Goals; Golgi; Golgi Apparatus; Golgi Complex; Growth; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Homolog; Homologous Gene; Homologue; Human; Human Pathology; Human, General; Idiopathic Parkinson Disease; Image; Impairment; In Vitro; Intracellular Communication and Signaling; Investigation; Lewy Body Parkinson Disease; Ligand Binding Protein; Link; Lipid Binding; Lou Gehrig Disease; Macropain; Macroxyproteinase; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediation; Membrane; Mice; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Multicatalytic Proteinase; Murine; Mus; Mutation; NRVS-SYS; Negotiating; Negotiation; Nerve; Nerve Cells; Nerve Degeneration; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System; Nervous System Diseases; Nervous System Physiology; Nervous system structure; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurologic Organ System; Neurologic function; Neurological Disorders; Neurological function; Neuron Degeneration; Neuronal Transmission; Neurons; Neurophysiology - biologic function; Onset of illness; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Peptide Domain; Phenocopy; Physiopathology; Plasma Membrane; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibition; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Domains; Protein Turnover; Proteins; Proteosome; Reagent; Regulation; Reporter; Resolution; Role; SEQ-AN; Sequence Analyses; Sequence Analysis; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Structure; Synapses; Synaptic; System; System, LOINC Axis 4; Technics, Genetic; Tertiary Protein Structure; Tissue Growth; VESCL; Vesicle; base; biological signal transduction; cell biology; dementia of the Alzheimer type; design; designing; disease onset; disease/disorder; disorder onset; dynactin; dynein ATP phosphohydrolase (tubulin translocating); dynein activator protein; fly; frontotemporal lobar dementia; fruit fly; gene product; genome mutation; guanosinetriphosphatase; human disease; imaging; in vivo; insoluble aggregate; interest; membrane structure; multicatalytic endopeptidase complex; mutant; nervous system disorder; nervous system function; neural degeneration; neural function; neurodegeneration; neurodegenerative illness; neurodegenerative phenotype; neurological disease; neurological pathology; neuronal; neuronal degeneration; neurotransmission; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; pathophysiology; pathway; plasmalemma; presynaptic; primary degenerative dementia; progressive neurodegeneration; protein aggregate; protein complex; protein degradation; public health relevance; response; rho; senile dementia of the Alzheimer type; social role; synapse function; synaptic function; tool; trafficking",Regulation of synaptic proteasome activity by the dynactin complex, NARRATIVE A hallmark of neurodegenerative disease is the early and prominent loss of synaptic contacts observed throughout the nervous system that tightly correlates with the decline in neural function. Recent data has demonstrated the importance synapse degeneration to the onset of disease but mechanisms involved in the maintenance of synaptic contacts remain unclear. We predict that studies aimed at elucidating the molecular mechanism associated with the regulation of synapse maintenance will have broad applications to neurological disease and provide the basis for novel strategies for treatment.,62811,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",A2,1,324844,
7921321,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS063227-01A2,,NINDS:363125;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BRONX,UNITED STATES,NEUROSCIENCES,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"KHODAKHAH, KAMRAN ;",6190710;,1R01NS063227,02/01/2010,01/31/2015,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT Agonists; 5-HT Receptors; 5-Hydroxytryptamine; 5-Hydroxytryptamine Agonists; 5-Hydroxytryptamine Receptors; 5-Hydroxytrytamine Agonist; 5HT; AMPA Receptors; Affect; Agonist; Ataxia; Ataxia, Hereditary; Ataxy; Cerebellar Ataxia; Cerebellar Incoordination; Cerebellum; Coordination Impairment; Data; Dendrites; Drugs; Dysfunction; Dyssynergia; Enteramine; Equilibrium; Excitatory Synapse; Familial Spinocerebellar Degenerations; Fiber; Functional disorder; Genetic Condition; Genetic Diseases; Glutamate Receptor; Glutamates; Goals; Hereditary Disease; Hereditary Spinocerebellar Degenerations; Hippophaine; Inherited Spinocerebellar Degenerations; Kainic Acid Receptors; Knowledge; L-Glutamate; Learning; Literature; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Synaptic Depression; Maintenance; Maintenances; Medication; Molecular Disease; Motor; Movement; Nerve Cells; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neurons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Play; Probability; Purkinje Cells; Purkinje's Corpuscles; Receptor Protein; Receptors, AMPA; Receptors, Kainate; Receptors, Kainic Acid; Role; Serotonergic Agents; Serotonergic Agonists; Serotonergic Drugs; Serotonin; Serotonin Agents; Serotonin Agonists; Serotonin Drugs; Serotonin Receptor Agonists; Symptoms; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Testing; Therapeutic; Therapeutic Uses; Treatment Efficacy; balance; balance function; base; body movement; cerebellar Purkinje cell; density; drug/agent; genetic disorder; hereditary disorder; improved; long term depression; neural control; neural regulation; neuronal; neuroregulation; pathophysiology; postsynaptic; public health relevance; receptor; serotonin receptor; social role; therapeutic efficacy; therapeutically effective; trafficking",Cerebellar Neuromodulation," A major function of the cerebellum is motor coordination and maintenance of balance. Dysfunction of the cerebellum, either as a consequence of a hereditary disorder or acquired deficiency, results in uncoordinated movement (ataxia). There is presently no cure for any of the hereditary ataxias, and there are few effective therapeutic options for ataxia in general. However, during the last two decades serotonergic agonists have been shown to be therapeutically effective in reducing the symptoms of a wide variety of cerebellar ataxias. The mechanism of action of serotonergic drugs is not understood. Given the therapeutic utility of serotonin it is important to delineate its mechanism of action in the cerebellum as a first step towards improving its therapeutic use in ataxia. The goal of this proposal is to delineate the effects of serotonergic drugs on cerebellar Purkinje cells.",63227,ZRG1,Special Emphasis Panel,A2,1,363125,
7780486,R01,NS,1,,01/15/2010,12/31/2010,PA-07-070,1R01NS063279-01A1,,NINDS:343438;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,ANESTHESIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"PELLIGRINO, DALE ALAN;",1866863;,1R01NS063279,01/15/2010,12/31/2014,"21+ years old; Accounting; Adhesion Molecule; Adhesions; Adult; Affect; Amine Oxidase (Copper-Containing); Amine[{..}]oxygen oxidoreductase (deaminating)(copper-containing); Animals; Antibodies; Apoplexy; Appearance; Behavior; Blood; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Blood leukocyte; Blood monocyte; Body Tissues; Brain; Cell Adhesion Molecules; Cell/Tissue, Immunohistochemistry; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Characteristics; Clinical; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Copper Amine Oxidase; Coupled; Cytofluorometry, Flow; Cytoplasmic Granules; Diamine Oxidase; Dichloromethylene Diphosphonate; Diphosphonate, Dichloromethylene; Drugs; Encapsulated; Encephalitis; Encephalon; Encephalons; Endothelial Cells; Endothelium; Enzymes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exhibits; Extracellular Matrix, Integrins; FLR; Face; Failure (biologic function); Female; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fore-Brain; Forebrain; Hematogenous; Heterophil Granulocyte; Histaminase; Hour; Human, Adult; IHC; IVM; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; Immunohistochemistry; Immunohistochemistry Staining Method; Infarction; Infiltration; Inflammation, Brain; Inflammatory; Inflammatory Response; Integrins; Intervention; Intervention Strategies; Ischemia; Ischemic Stroke; Laboratories; Leukocytes; Leukocytes, Mononuclear; Link; Liposomal; Liposomes; Lymphocyte; Lymphocytic; Mammals, Rats; Mammals, Rodents; Marrow Neutrophil; Marrow leukocyte; Marrow monocyte; Measurement; Mediating; Medication; Microfluorometry, Flow; Middle Cerebral Artery Occlusion; Modeling; Monitor; Mononuclear Leukocytes; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Non-Granular Leukocyte; Occlusion, Middle Cerebral Artery; Pathway interactions; Pattern; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Process; Prosencephalon; Proteins; Protocol; Protocols documentation; Publishing; Rat; Rattus; Recovery; Reperfusion Therapy; Reporting; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Rodent; Rodent Model; Rodentia; Rodentias; Role; Selectins; Semicarbazide-Sensitive Amine Oxidase; Stimulus; Stroke; Surface; Surgical sutures; Sutures; T-Cells; T-Lymphocyte; Testing; Therapeutic; Therapeutic Estrogen; Thymus-Dependent Lymphocytes; Time; Tissues; Vascular Accident, Brain; White Blood Cells; White Cell; adult human (21+); agranulocyte; base; brain attack; cell adhesion protein; cerebral vascular accident; clinical efficacy; clinical investigation; clodronate; design; designing; diabetic; diamino oxhydrase; drug efficacy; drug/agent; experiment; experimental research; experimental study; facial; failure; flow cytophotometry; gene product; granule; improved; infarct; inhibitor; inhibitor/antagonist; interventional strategy; intravital microscopy; lymph cell; male; monocyte; neurobehavioral; neuronal; neuropathology; neuroprotection; neurotoxic; neutrophil; novel; pathway; prevent; preventing; public health relevance; reperfusion; research study; response; social role; stroke; therapeutic target; thymus derived lymphocyte; trafficking; vascular; vascular bed; white blood cell; white blood corpuscle",Vascular adhesion protein-1 (VAP-1) as a therapeutic target in stroke,"  Post-ischemic brain inflammation can play a major role in the cerebral neuropathology that occurs following stroke. One potentially key player in that inflammatory attack is the leukocyte. These blood-derived cells may enter the brain after a stroke and release neurotoxic agents. The failure of anti-leukocyte strategies in clinical trials to date may, in part, relate to the presence of multiple leukocyte subsets and redundancy in the pathways responsible for their passage into the brain. The present project utilizes a selective pharmacologic approach that targets a novel protein which appears to be important in the trafficking of all leukocyte subsets and, therefore, may prove to have wide-ranging clinical efficacy.",63279,ANIE,Acute Neural Injury and Epilepsy Study Section,A1,1,343438,
7890013,R01,NS,1,,02/01/2010,12/31/2010,PA-07-070,1R01NS064084-01A2,,NINDS:326892;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,,07,068477546,US,IL,60611,REHABILITATION INSTITUTE OF CHICAGO,"BEER, RANDALL FREDERICK;DHAHER, YASIN YOUSEF (contact);",8293743 (contact);8293759;,1R01NS064084,02/01/2010,12/31/2014,"Abnormal gait; Algorithms; Ankle; Apoplexy; Articulation; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Clinical Assessment Tool; Clinical Research; Clinical Study; Computers; Conflict; Conflict (Psychology); Contralateral; Coupling; Coxa; Data; Dependence; Development; Dysfunction; Dyskinesia Syndromes; Elements; Equilibrium; Evoked Potentials, Motor; Exhibits; Extremities; Freedom; Functional disorder; Future; Gait; Gait abnormality; Gait disorder; Gait disturbances; Generations; Hip; Hip Joint; Hip region structure; Human; Human, General; Impairment; Individual; Ipsilateral; Isometric Exercise; Isometrics; Joints; Knee; Knowledge; Lesion; Liberty; Limb structure; Limbs; Linear Regressions; Lower Extremity; Lower Limb; Magnetism; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrum inferius; Methods and Techniques; Methods, Other; Metric; Motion; Motor; Motor Cortex; Motor Evoked Potentials; Motor output; Movement; Movement Disorder Syndromes; Movement Disorders; Muscle; Muscle Tissue; Muscle Weakness; Muscle, Skeletal; Muscle, Voluntary; Muscle-Setting Exercise; Muscular Weakness; Nervous; Neurologic; Neurological; Neuromechanics; Non-Trunk; Output; Participant; Patients; Pattern; Pelvic; Pelvic Region; Pelvis; Phase; Physical Health Services / Rehabilitation; Physiopathology; Pilot Projects; Posture; Procedures; Production; Protocol; Protocols documentation; Quantitative Evaluations; Recovery; Regio tarsalis; Regressions, Linear; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Role; Skeletal Muscle Tissue; Skeletal muscle structure; Static Exercise; Stroke; Structure; Survivors; Tarsal Bone; Tarsus; Techniques; Testing; Torque; Training; Transcranial magnetic stimulation; Vascular Accident, Brain; Walking; Weight; Work; balance; balance function; base; body movement; brain attack; cerebral vascular accident; chronic stroke; design; designing; exoskeleton; experiment; experimental research; experimental study; flexibility; improved; independent component analysis; insight; instrument; intervention design; invertebrate cuticle; kinematics; magnetic; motor control; neural; novel; pathophysiology; pilot study; post stroke; poststroke; public health relevance; rehabilitative; relating to nervous system; research study; response; social role; stroke; stroke recovery; stroke rehab; stroke rehabilitation; therapy design; time use; treatment design",Neuromechanical Substrates for Post Stroke Asymmetric Gait," Narrative Following stroke, stereotypical abnormal gait patterns emerge during recovery. It is possible that these abnormal patterns are the result of inappropriate combinations of muscle activations. Since the few existing studies have shown conflicting results, we propose to quantify these lower limb patterns, identify the possible muscle activation combinations producing these patterns, and take the important first stop toward identifying the neurological basis for these gait impairments. The results of these studies will assist in developing rehabilitation techniques and strategies and identify novel neurological targets to improve functional movement in stroke survivors.",64084,MFSR,"Motor Function, Speech and Rehabilitation Study Section",A2,1,326892,
7782142,R01,NS,1,,01/15/2010,11/30/2010,PA-07-070,1R01NS064135-01A1,,NINDS:287656;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,PHYSIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"MACCAFERRI, GIANMARIA ;",6722190;,1R01NS064135,01/15/2010,11/30/2013,"Abscission; Affect; Ammon Horn; Anatomic; Anatomical Sciences; Anatomy; Animals; Astrocytes; Astrocytus; Astroglia; Biology; Brain region; C-X-C Chemokine Receptor Type 4; CD184 Antigen; CXCL12 protein; CXCR4 Receptors; Cajal-Retzius cells; Cell Communication and Signaling; Cell Signaling; Chemokine (C-X-C Motif) Ligand 12; Chemokine (C-X-C Motif) Receptor 4; Chemokine, CXC Motif, Receptor 4; Connector Neuron; Cornu Ammonis; Cytokines, Chemotactic; Data; Development; Electrophysiology; Electrophysiology (science); Engineering; Engineerings; Epilepsy; Epileptic Seizures; Epileptics; Epileptogenesis; Excision; Extirpation; Fusin; Future; Gliosis; Hippocampus; Hippocampus (Brain); Homologous Chemotactic Cytokines; Hortega cell; In Vitro; Intercalary Neuron; Intercalated Neurons; Intercrines; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Intractable Epilepsy; LPS-Associated Protein 3; Lead; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Mediating; Medical; Mice, Transgenic; Microglia; Molecular; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neuropeptide Y Receptor Y3; Neurophysiology / Electrophysiology; Patients; Pattern; Pb element; Pharmacological Treatment; Pre-B Cell Growth Stimulating Factor; Prevention strategy; Preventive strategy; Property; Property, LOINC Axis 2; Receptor, LESTR; Removal; SDF-1; SDF-1 Receptor; SDF-1alpha; SDF1/PBSF Receptor CXCR4; SIS cytokines; Science of Anatomy; Sdf1 protein; Seizure Disorder; Seizures; Seven-Transmembrane-Segment Receptor, Spleen; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Source; Stromal Cell-Derived Factor 1; Stromal Cell-Derived Factor 1 Receptor; Surgical Removal; Synapses; Synaptic; Testing; Therapeutic; Transgenic Mice; Work; anatomy; base; biological signal transduction; cell type; chemoattractant cytokine; chemokine; conventional therapy; epilepsia; epileptiform; epileptogenic; excitatory neuron; gitter cell; hIRH; heavy metal Pb; heavy metal lead; hippocampal; in vitro activity; insight; mesoglia; microglial cell; microgliocyte; neuronal; novel; perivascular glial cell; postnatal; public health relevance; receptor-mediated signaling; resection; stromal cell-derived factor-1alpha",Cajal-Retzius Cells and Neuronal Signaling in Postnatal Cortical Networks," Project Narrative The purpose of this application is to identify novel neuronal mechanisms that contribute to epileptogenesis in a specific microcircuit of the hippocampus, which is a brain region with a low threshold for seizures. In more detail, this proposal concerns epileptiform activity in vitro that is sustained by excitatory GABAergic input and is similar to dynamic patterns occurring in some epileptic patients who do not respond to conventional therapies. These epileptic patients require surgical removal of the epileptic focus: hence understanding the cellular details underlying their illness is imperative to provide new strategies for medical treatments. .",64135,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,A1,1,287656,
7890685,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS064341-01A1,,NINDS:318298;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,ANESTHESIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"LUO, ZHIGANG DAVID;",1894390;,1R01NS064341,02/01/2010,01/31/2014,"1-(aminomethyl)cyclohexaneacetic Acid; Allergy; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antibodies; Antinociceptive Agents; Antinociceptive Drugs; Behavioral; Blotting, Western; Body Tissues; Calcium Channel; Calcium Channel Antagonist Receptor; Cells; Clinical; Common Rat Strains; Complex; Data; Detection; Development; Disease; Disorder; Dorsal; Dorsal Root Ganglia; Dose; Excitatory Synapse; Ganglia, Spinal; Goals; Hypersensitivity; Immune Precipitation; Immunoprecipitation; In Vitro; Injury; Intrathecal Injections; Ion Channels, Calcium; Knockout Mice; Knowledge; Left; Lumbar Regions; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Mediating; Medulla Spinalis; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Monitor; Murine; Mus; Neurontin; Neuropathy; Nociception; Null Mouse; Pain; Painful; Pathway interactions; Peripheral nerve injury; Phenotype; Play; Proteins; RNA, Messenger; Rat; Rattus; Receptors, Calcium Channel Blocker; Regions, Lumbar; Role; Slice; Spinal; Spinal Cord; Spinal Ganglia; Spinal Nerves; Spinal nerve structure; Synapses; Synaptic; Syndrome; TSP-4; TSP4; Techniques; Testing; Therapeutic Agents; Time; Tissues; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); VDCC; Voltage-Dependent Calcium Channels; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; allodynia; analgesia; behavior test; behavioral pharmacology; behavioral test; biochemical model; cell type; chronic pain; chronic painful condition; disease/disorder; dorsal horn; dorsal root ganglion; experiment; experimental research; experimental study; gabapentin; gene product; injured; mRNA; nerve injury; neural injury; neuropathic; neuropathic pain; next generation; nociceptive; overexpression; painful neuropathy; pathway; prevent; preventing; protein blotting; public health relevance; research study; social role; synapse formation; synaptogenesis; thrombospondin 4; voltage",Mechanism of Calcium Channel Cava2d1 Protein Mediated Neuropathic Pain,"  Chronic pain derived from nerve injury, or neuropathic pain, is a common clinical syndrome lacking specific and effective therapeutic agents due to the fact that its cellular mechanisms are poorly understood. Existing data indicate that injury-induced voltage-gated calcium channel ¨2¨-1 subunit (Cav¨2¨1) in dorsal root ganglia and spinal cord contributes to the development of neuropathic pain. However, mechanisms underlying injury-induced Cav¨2¨1 in neuropathic pain are not known. We hypothesize that elevated Cav¨2¨1 interacts with thrombospondin-4 (TSP4) post injury in promoting synapse formation, and abnormal synapse formation plays a causal role in neuropathic pain. We will test this hypothesis using genetically modified mice, nerve injury models, biochemical, electrophysiological, and behavioral pharmacology approaches. Completion of this study will provide important information for the understanding of neuropathic pain mechanisms and the development of next generation of neuropathic pain medications.",64341,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",A1,1,318298,
7889010,R01,NS,1,,02/01/2010,01/31/2011,PA-08-015,1R01NS064583-01A2,,NINDS:370781;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"GU, CHENGHUA ;",6273889;,1R01NS064583,02/01/2010,01/31/2015,"21+ years old; ALS; Address; Adult; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyotrophic Lateral Sclerosis; Axon; B2 antigen, Xenopus; Blood Vessels; Blood capillaries; Brain; Cancer Treatment; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Central Nervous System; Chronotropism, Cardiac; Chronotropisms, Cardiac; Complex; Coupled; Cues; DNA Sequence Rearrangement; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependency; Dependency (Psychology); Development; Diabetic Neuropathies; Diagnosis; Encephalon; Encephalons; Endothelial Cells; Epileptiform Neuralgia; Fothergill Disease; Fothergill's neuralgia; GAP Proteins; GTPase-Activating Proteins; GWAS; Gehrig's Disease; Genetic; Genetically Engineered Mouse; Growth Cones; Heart Rate; Human; Human, Adult; Human, General; Image; Intracellular Communication and Signaling; Knockout Mice; Ligands; Lou Gehrig Disease; MS (Multiple Sclerosis); Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Motility; Motility, Cellular; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Multiple Sclerosis; Murine; Mus; NRVS-SYS; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurons; Null Mouse; Nutrient; O element; O2 element; Oxygen; PNS Diseases; Pathway interactions; Pattern; Peripheral; Peripheral Nerve Diseases; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevention therapy; Primary Senile Degenerative Dementia; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rearrangement; Receptor Protein; Recruitment Activity; Role; Running; Sclerosis, Disseminated; Semaphorins; Sensory; Sequence-Specific Posttranscriptional Gene Silencing; Serine Kinase; Serine-Threonine Kinases; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Structure; System; System, LOINC Axis 4; Testing; Threonine Kinase; Tic Douloureux; Toxin; Trifacial Neuralgia; Trigeminal Neuralgia; Trigeminal Pain; Trigeminal System; Vascular System; Vibrissae; Whiskers; adult human (21+); angiogenesis; anticancer therapy; axon growth cone guidance; axon guidance; base; biological signal transduction; cancer therapy; capillary; cell motility; cell type; dementia of the Alzheimer type; diabetes-associated neuropathy; emotional dependency; experiment; experimental research; experimental study; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; guanosinetriphosphatase activating protein; imaging; improved; in vitro Assay; in vivo; innervation; insight; insular sclerosis; mouse model; neovascularization; nerve supply; nervous system disorder; neural; neural circuit; neural circuitry; neurodegenerative illness; neurological disease; neuron development; neuronal; novel; pathogen; pathway; plexin; prevent; preventing; primary degenerative dementia; protein function; public health relevance; receptor; recruit; relating to nervous system; research study; response; senile dementia of the Alzheimer type; social role; somatosensory; trifocal neuralgia; trigeminal; tumor; vascular; whole genome association studies; whole genome association study",The Role of Semaphorins in Axon and Blood Vessel Guidance," Project Narrative Understanding the interactions between vascular and nervous systems will advance the diagnosis, therapy, and prevention of several neurological diseases, including diabetic neuropathy and trigeminal neuralgia. Moreover, emerging evidence shows some neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), that once were thought to be caused primarily by intrinsic neuronal defects, actually may be related to vascular abnormalities. Finally, since mechanisms that control angiogenesis during development are likely to be essential for neovascularization in tumors, this study may have a direct impact on cancer treatment.",64583,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",A2,1,370781,
7928666,R01,NS,1,,02/01/2010,01/31/2011,PA-07-085,1R01NS065027-01A1,,NINDS:320469;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,NEUROSCIENCES,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"POZZO-MILLER, LUCAS D.;",3146974;,1R01NS065027,02/01/2010,01/31/2015,"0-11 years old; Affect; Ammon Horn; Area; Assay; Autism; Autism, Early Infantile; Autism, Infantile; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome; Autistic Disorder; Axon; BDNF; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Birth; Brain; Brain-Derived Neurotrophic Factor; Cell Communication and Signaling; Cell Signaling; Cerebroatrophic Hyperammonemia; Child; Child Youth; Childhood; Children (0-21); Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Coloring Agents; Connector Neuron; Cornu Ammonis; DNA; DNA Recombination; DNA recombination (naturally occurring); DNA-Binding Proteins; Dentate Fascia; Dentate Gyrus; Deoxyribonucleic Acid; Development; Disease; Disorder; Disturbance in cognition; Dyes; Encephalon; Encephalons; Equilibrium; Excitatory Synapse; Exons; Family; Fascia Dentata; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Human, Child; IGF-1; IGF-I; IGF-I-SmC; IGF1; Image; Impaired cognition; Individual; Inhibitory Synapse; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Kanner's Syndrome; Knockout Mice; Link; MGC34632; Mammals, Mice; MeCP-2 protein; MeCP2; MeCP2 protein; Mediating; Membrane; Mental Retardation; Methyl CpG Binding Protein 2; Methyl CpG binding protein (MeCP2); Methyl CpG binding protein MeCP2; Methyl-CpG binding protein 2; Methyl-CpG-Binding Protein 2; Methyl-DNA binding protein MECP2; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular Interaction; Murine; Mus; Mutation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodevelopmental Disorder; Neurological Development Disorder; Neurons; Null Mouse; Parturition; Pathway interactions; Phenotype; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Pyramidal neuron; Receptor Protein; Recombination; Recombination, Genetic; Rett Disorder; Rett Syndrome; Rett syndrome (RS, RTS); Signal Transduction; Signal Transduction Systems; Signaling; Site; Slice; Societies; Somatomedin C; Structure of dentate gyrus; Synapses; Synaptic; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenes; V (voltage); Whole-Cell Recordings; autism spectrum disorder; balance; balance function; base; biological signal transduction; children; cognitive dysfunction; cognitive loss; cognitively impaired; dentate gyrus; disease/disorder; experiment; experimental research; experimental study; genetic promoter element; genome mutation; granule cell; hippocampal; hippocampal pyramidal neuron; imaging; loss of function mutation; membrane structure; methyl-CpG (cytosine-guanine dinucleotide) binding protein 2; mossy fiber; neuronal; neuropathology; novel; pathway; pediatric; postnatal; presynaptic; prevent; preventing; public health relevance; receptor; research study; synapse formation; synapse function; synapse inhibition; synaptic function; synaptic inhibition; synaptogenesis; voltage; youngster",MeCP2 Modulation of BDNF Signaling: Shared Mechanisms of Rett and Autism," Rett syndrome (RTT) is an X-linked neurodevelopmental disorder associated with autism and mental retardation, which is caused by mutations in MECP2, a DNA-binding protein that regulates target genes, including Bdnf. We will test whether impaired development of hippocampal inhibitory synapses due to reduced BDNF release contributes to the excitatory/inhibitory imbalance of synaptic function implicated in cognitive impairments and autism in RTT.",65027,ZRG1,Special Emphasis Panel,A1,1,320469,
7899513,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065052-01A2,,NINDS:321152;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LEXINGTON,UNITED STATES,NEUROLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"LIFSHITZ, JONATHAN ;",2052205;,1R01NS065052,02/01/2010,01/31/2015,"21+ years old; Acquired brain injury; Acute; Address; Adult; Agitation; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Atrophic; Atrophy; Attenuated; Axon; Behavior; Behavioral; Biological Models; Blood Vessels; Brain; Brain Injuries; Brain region; CNS plasticity; Cellular Membrane; Chronic; Common Rat Strains; Communities; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Diffuse; Diffuse Brain Injury; Dose; Drugs; Dysfunction; Encephalon; Encephalons; Excitement, Psychomotor; Face; Figs; Figs - dietary; Freezing; Functional disorder; Gene Expression; Genes, Immediate-Early; Goals; Human, Adult; INFLM; Ibuprofen; Immediate-Early Genes; Inflammation; Inflammatory; Injury; Injury, Diffuse Brain; Intervention; Intervention Strategies; Left; Liquid substance; Mammals, Rats; Mammals, Rodents; Measures; Mechanics; Medical; Medication; Messenger RNA; Model System; Modeling; Models, Biologic; Molecular; Morbidity; Morbidity - disease rate; Motrin; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Dysfunctions; Neurological; Neuronal Plasticity; Neurons; Pathologic Processes; Pathological Processes; Percussion; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Health Services / Rehabilitation; Physiopathology; Process; Psychomotor Agitation; Psychomotor Hyperactivity; Psychomotor Restlessness; QOL; Quality of life; RNA, Messenger; Rat; Rattus; Regimen; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Resolution; Restlessness; Rodent; Rodentia; Rodentias; Sensory; Severities; Societies; Somatosensory Cortex; Survivors; Symptoms; Testing; Therapeutic; Time; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Ventral Posterior Nucleus; Ventral Posterior Thalamic Nucleus; Vibrissae; Whiskers; adult human (21+); alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid; base; brain damage; brain lesion (from injury); clinical relevance; clinically relevant; drug/agent; effective therapy; experience; facial; fluid; improved; in vivo Model; injured; innovate; innovation; innovative; interventional strategy; liquid; mRNA; male; man; man's; model organism; neural circuit; neural circuitry; neural plasticity; neurodegenerative illness; neuroinflammation; neurological dysfunction; neuronal; neuropathology; neuroplasticity; novel; organic base; p-Isobutylhydratropic Acid; pathophysiology; prevent; preventing; protein expression; psychologic; psychological; public health relevance; rehabilitative; response; somatosensory; somesthetic sensory cortex; tool; traumatic brain damage; treatment strategy; vascular",Neural circuit disruption by diffuse brain injury: basis for morbidity & therapy," 7. Project Narrative  The present proposal focuses on the persistent morbidity experienced by diffuse brain injury survivors, for whom treatment options are limited. In diffuse brain-injured rats, aberrant responses to whisker stimulation will be employed as a tool to identify pathological and reparative mechanisms associated with somatosensory whisker circuit disruption. By developing, validating and implementing an animal model of one discrete post- traumatic morbidity, significant advancements can be made towards reshaping first one, then other, brain- injured circuits in rodents and man.",65052,BINP,Brain Injury and Neurovascular Pathologies Study Section,A2,1,321152,
7781204,R01,NS,1,,01/18/2010,11/30/2010,PA-07-070,1R01NS065053-01A1,,NINDS:332500;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,ANATOMY/CELL BIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"DIANTONIO, AARON ;",1931498;,1R01NS065053,01/18/2010,11/30/2013,"Apoptosis; Apoptosis Pathway; Axon; Axotomy; Bleb; Blister; Bulla; Bullous Lesion; Cell Death, Programmed; Chimera Protein; Chimeric Proteins; Commit; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Diabetes Mellitus; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drosophila; Drosophila genus; EC 2.7; EC 2.7.2-; Exposure to; Extracellular Signal-Regulated Kinases; Fruit Fly, Drosophila; Fusion Protein; Glaucoma; Goals; Inherited Neuropathy; Injury; Isoforms; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; Lead; Length; MAP Kinase 8 Gene; MAP Kinase Kinase Kinase; MAP kinase; MAP3 Kinases; MAPK; MAPK8; MAPK8 gene; MAPKKKs; Mammals, Mice; Mechanics; Membrane; Mice; Mice, Mutant Strains; Micro-tubule; Microtubules; Mitogen-Activated Protein Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Modeling; Molecular; Murine; Mus; Mutant Strains Mice; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neurons; Neuropathy; Neurotoxins; PRKM8; Pathway interactions; Pb element; Peripheral; Peripheral Nerves; Phagocytes; Phagocytic Cell; Phase; Phosphotransferases; Process; Programs (PT); Programs [Publication Type]; Protein Isoforms; Public Health; Regulation; Research; Role; SAPK1; SCG-10 protein; SCG10 mRNA product; SCG10 protein; Stimulus; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Therapeutic; Transphosphorylases; Trauma; Vesication; amebocyte; apoptosis of neuronal cells; axonal degeneration; axonopathy; chemotherapy; diabetes; disability; disease/disorder; fruit fly; glaucomatous; heavy metal Pb; heavy metal lead; hereditary neuropathy; improved; in vivo; in vivo Model; injury response; insight; membrane structure; mouse mutant; nervous system disorder; neurodegenerative illness; neurological disease; neuromuscular; neuron apoptosis; neuron toxicity; neuronal; neuronal apoptosis; neuronal toxicity; neuropathic; neurotoxicant; neurotoxicity; overexpression; pathway; prevent; preventing; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; public health medicine (field); public health relevance; response; response to injury; social role; superior cervical ganglion-10; therapeutic target",REGULATION OF AXONAL DEGENERATION BY THE DLK KINASE," Project Narrative:  This research is relevant to public health because it will improve our understanding of the mechanism of axonal degeneration following injury and disease. Axonal degeneration is a prominent component of many neurological disorders including neuropathies associated with trauma, diabetes, glaucoma, chemotherapy-induced neurotoxicity, and neurodegenerative diseases. Identifying components of the pathway in axons that promote degeneration will provide insights into the fundamental mechanism underlying axonal degeneration as well as potential therapeutic targets for the many neurological diseases characterized by axonal degeneration.",65053,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",A1,1,332500,
7789795,R01,NS,1,,01/15/2010,12/31/2010,PA-07-070,1R01NS065219-01A1,,NINDS:334688;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,NEUROLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"WEISS, JOHN H;",1865102;,1R01NS065219,01/15/2010,12/31/2014,"Abscission; Acidosis; Acids; Acquired brain injury; Acute; Address; Ammon Horn; Apoplexy; Axon Terminals; Binding; Binding (Molecular Function); Brain; Brain Injuries; Buffers; Cations; Cations, Divalent; Cell Death; Cell Membrane Permeability; Cells; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chelating Agents; Chelators; Cognitive Discrimination; Complex; Complexons; Cornu Ammonis; D-Glucose; Death; Development; Dextrose; Discrimination; Discrimination (Psychology); Divalent Cations; Encephalon; Encephalons; Event; Excision; Extirpation; Generations; Glucose; Glutamates; Growth Inhibitory Factor, Brain; Growth Inhibitory Factor, Neurotrophic; Hippocampus; Hippocampus (Brain); Hour; Imaging Procedures; Imaging Techniques; Individual; Injury; Intervention; Intervention Strategies; Ions; Ischemia; Ischemic Brain Injury; Ischemic Neuronal Injury; Knock-out; Knockout; L-Glutamate; Lead; MT-III; MT3 protein, human; Mammals, Mice; Mediating; Membrane; Metallothionein 3; Metallothionein-III; Metals; Mice; Mice, Transgenic; Mitochondria; Modeling; Molecular Interaction; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motion; Mouse Strains; Movement; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Endings, Presynaptic; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neuron Degeneration; Neuronal Injury; Neurons; Neurotransmitters; O element; O2 element; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen; Pathway interactions; Pb element; Phase; Play; Preparation; Presynaptic Terminals; Process; Proteins; Pyramidal neuron; Removal; Reperfusion Therapy; Role; Route; Seizures; Simulate; Slice; Source; Staging; Stroke; Surgical Removal; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; Technics, Imaging; Testing; Therapeutic Intervention; Time; Transgenic Mice; Transgenic Organisms; Vascular Accident, Brain; Zinc; Zn element; aging population; base; body movement; brain attack; brain damage; brain lesion (from injury); brain tissue; cerebral vascular accident; channel blockers; chelation; cyclophilin D; cyclophilin-40; deprivation; effective therapy; electron acceptor; extracellular; gene product; growth inhibitory factor; heavy metal Pb; heavy metal lead; hippocampal; hippocampal pyramidal neuron; human GIF; human MT3 protein; injured; insight; intervention therapy; interventional strategy; ischemic brain damage; loss of function; membrane permeability; membrane structure; metallothionein III; mitochondrial; mitochondrial dysfunction; necrocytosis; neural degeneration; neurodegeneration; neuron cell death; neuron injury; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; new approaches; novel approaches; novel strategies; novel strategy; pathway; public health relevance; reperfusion; resection; response; social role; stroke; transgenic; uptake","Zn2+, mitochondria and the induction of ischemic neurodegeneration","  Despite being a cause of tremendous morbidity to the aging population, treatment of stroke is presently poor in part because of limited understanding of the events set in motion by ischemia that culminate in loss of function and nerve cell death. In this study, nerve cells in slices of mouse brain will be examined during and after simulated ischemia to directly examine movements and effects of the metal ion, zinc, which seems to play critical yet presently poorly understood in the triggering of ischemic brain injury. It is hoped that these studies will provide new insights into critical early events in ischemia that will suggest new approaches for new and better treatments to decrease brain damage.",65219,NOMD,Neural Oxidative Metabolism and Death Study Section,A1,1,334688,
7895476,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065395-01A2,,NINDS:294175;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"BEAUCHAMP, MICHAEL S;",7942062;,1R01NS065395,02/01/2010,01/31/2015,"Accounting; Area; Auditory; Behavior; Behavioral; Brain; Classification; Cognitive; Effectiveness; Encephalon; Encephalons; Environment; Functional Magnetic Resonance Imaging; Goals; Hand; Hearing; Individual; Intraparietal Sulcus; Knowledge; Link; MRI, Functional; Magnetic Resonance Imaging, Functional; Modality; Modeling; Nervous; Nervous System, Brain; Operation; Operative Procedures; Operative Surgical Procedures; Pattern; Perception; Performance; Process; Sensory; Speech; Stimulus; Structure of intraparietal sulcus; Structure of superior temporal sulcus; Superior Temporal Sulcus; Surgical; Surgical Interventions; Surgical Procedure; Systematics; Tactile; Testing; Touch; Touch sensation; Transcranial magnetic stimulation; Visual; Weight; auditory stimulus; base; blood oxygen level dependent; driving behavior; experiment; experimental research; experimental study; fMRI; hearing perception; human subject; intraparietal sulcus; multisensory; neural; neural mechanism; neural model; neuromechanism; public health relevance; relating to nervous system; research study; response; somatosensory; sound perception; surgery; visual stimulus",Neural Mechanisms of Optimal Multisensory Integration, Project Narrative  Multisensory integration is at the core of many cognitive phenomena. We will use functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) in normal human subjects to study the organization and operation of the brain during multisensory integration.,65395,COG,Cognitive Neuroscience Study Section,A2,1,294175,
7909154,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065450-01A1,,NINDS:320682;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,NEUROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"PARENT, JACK M;",1873822;,1R01NS065450,02/01/2010,01/31/2015,"21+ years old; ATGN; Acute; Address; Adult; Allografting; Ammon Horn; Antigens; Apoplexy; Area; Assay; Attention; Autologous; BACs (Chromosomes); Bacterial Artificial Chromosomes; Behavior; Bioassay; Biologic Assays; Biological Assay; Brain; Brain Diseases; Brain Disorders; Cell Line; Cell Lines, Strains; Cell Surface Antigens; Cell Transplants; CellLine; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Common Rat Strains; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Cytogenetic Analyses; Cytogenetic Analysis; Cytogenetic Technics; Cytogenetic Techniques; Development; Dysembryoma; Encephalon; Encephalon Diseases; Encephalons; Environment; Fibroblasts; GFP; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Generalized Growth; Genes; Goals; Green Fluorescent Proteins; Growth; Heterograft; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Infarction; Injection of therapeutic agent; Injections; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Ischemia; Knowledge; Light; Mammals, Rats; Man (Taxonomy); Man, Modern; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Cytogenetic Technics; Molecular Cytogenetic Techniques; Natural immunosuppression; Natural regeneration; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuronal Growth; Neurons; Photoradiation; Population; Profilings, Gene Expression; Progenitor Cell Transplantation; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Rat; Rattus; Recovery; Recovery of Function; Regeneration; Reporter; Risk; Safety; Skin; Somatic Cell; Source; Staging; Stem Cell Transplantation; Stem cell transplant; Striate Body; Striatum; Stroke; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Techniques; Teratoid Tumor; Teratoma; Testing; Tissue Growth; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Transplantation; Transplantation, Heterologous; Transplants, Cell; Tubulin; Vascular Accident, Brain; Xenograft; Xenograft procedure; Xenotransplantation; adult human (21+); base; behavior influence; behavioral influence; brain attack; cell type; cerebral vascular accident; cultured cell line; functional recovery; functional restoration; genetic manipulation; hESC; hippocampal; human ES cell; human ES cell lines; human ESC; human embryonic stem cell; human embryonic stem cell line; immunogen; immunosuppression; improved; in vivo; induced pluripotent stem cell; infarct; injured; insight; migration; nerve stem cell; nervous system disorder; neural progenitor cells; neurogenesis; neurological disease; neuronal; neuronal progenitor; neuronal progenitor cells; neuronal replacement; novel; ontogeny; public health relevance; regenerate; regenerative therapy; repair; repaired; restorative treatment; restore function; restore functionality; restore lost function; self-renewal; striatal; stroke; stroke therapy; subventricular zone; transplant",Neural Progenitor Grafting for Restorative Stroke Therapy," Project Narrative  Stroke is a common and potentially devastating neurological disorder with no proven regenerative therapies. This proposal aims to derive neural stem cells (NSCs) from human embryonic stem cells or reprogramming of human adult skin cells, and to use a stroke model to identify the optimal NSC grafts for brain reparative stroke therapy. Progress in this area offers advances toward novel cell-based restorative therapies for stroke and other brain insults.",65450,BINP,Brain Injury and Neurovascular Pathologies Study Section,A1,1,320682,
7788539,R01,NS,1,,01/15/2010,11/30/2010,PA-07-070,1R01NS065714-01A1,,NINDS:329219;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SALT LAKE CITY,UNITED STATES,PATHOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"FUJINAMI, ROBERT S;",1865276;,1R01NS065714,01/15/2010,11/30/2013,"Acute; Adenoviridae; Adenoviruses; Affect; American; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-epileptic; Anti-inflammatory; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Antigens, Viral; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior; Biological Models; Brain; Brain Part; C57BL/6 Mouse; Cachectin; Cachectin-Tumor Necrosis Factor; Causality; Cell Death, Programmed; Cells; Central Nervous System; Central Nervous System Infections; Central Nervous System Infectious Disease; Central Nervous System Infectious Disorder; Central Nervous System Viral Diseases; Cessation of life; Chimera; Chimera organism; Common Rat Strains; Cornu Ammonis; DNA Nucleotidylexotransferase; DNTT; Death; Deoxynucleotidyl Transferase; Deoxynucleotidyltransferase; Desoxynucleotidyl Transferase; Desoxynucleotidyltransferase; Development; Differentiation Factor, B-Cell; Disease; Disorder; Drugs; EC 2.7.7.31; Electric Stimulation; Electrical Stimulation; Encephalitis; Encephalitis Viruses; Encephalitis, Viral; Encephalon; Encephalons; Enterovirus 71; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Epileptogenesis; Etiology; Experimental Animal Model; Family Picornaviridae; HPGF; Hepatocyte-Stimulating Factor; Herpesviridae; Herpesviruses; Hippocampus; Hippocampus (Brain); Human; Human, General; Hybridoma Growth Factor; IFN; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; INFLM; Immune; Immune response; Immunodeficient Mouse; Incidence; Individual; Infection; Infections, Viral CNS; Infectious Encephalomyelitis, Viral; Inflammation; Inflammation, Brain; Influenza Virus; Interferons; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; Intervention; Intervention Strategies; Investigation; Killings; Lead; Life; Limbic System; Lymphocyte-Stimulating Hormone; MGI-2; Macrophage Cell Factor; Mammals, Mice; Mammals, Rabbits; Mammals, Rats; Man (Taxonomy); Man, Modern; Medication; Mice; Model System; Modeling; Models, Biologic; Mouse Polioviruses; Murine; Mus; Myeloid Differentiation-Inducing Protein; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuronal Dysfunction; Neurons; Nucleoside-triphosphate[{..}]DNA deoxynucleotidylexotransferase; Olfactory Bulb; Oryctolagus cuniculus; Pathogenesis; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Picornaviridae; Picornaviruses; Plague; Plasmacytoma Growth Factor; Polioviruses, Murine; Prevention; Production; Public Health; Pyramidal Cells; Rabbit, Domestic; Rabbits; Rat; Rattus; Recurrence; Recurrent; Refractory; Relative; Relative (related person); Reporting; Respiratory syncytial virus; Risk; Risk Factors; Role; Rotavirus; Route; Seizure Disorder; Seizures; Staining and Labeling; Staining method; Stainings; Stains; Structure; Structure of olfactory bulb; T Helper Factor; TMEV; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TdT; Temporal Lobe Epilepsy; Terminal Addition Enzyme; Terminal Deoxynucleotidyl Transferase; Terminal Deoxynucleotidyltransferase; Terminal Deoxyribonucleotidyl Transferase; Terminal Deoxyribonucleotidyltransferase; Testing; Theiler Murine Encephalomyelitis Virus; Theiler's Virus; Theiler's encephalomyelitis virus; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Viral; Viral Antigens; Viral Diseases; Viral Encephalitis; Viral Infections, Central Nervous System; Virus; Virus Diseases; Viruses, General; Yersinia pestis disease; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; epilepsia; epileptiform; epileptogenic; heavy metal Pb; heavy metal lead; herpes virus; hippocampal; host response; immunoresponse; influenzavirus; influenzavirus (unspecified); interferon beta 2; interventional strategy; lymphocyte activating factor; model organism; mouse model; mutant; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neurotoxic; neurotropic; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; novel therapeutics; olfactory bulb; public health medicine (field); public health relevance; social role; suicidal risk; suicide risk; tumor necrosis factor (unspecified); viral infection; virus antigen; virus host interaction; virus infection",Virus-Host Interactions that Lead to Epilepsy," PROJECT NARRATIVE  Viral infections of the central nervous system result in encephalitis. Viral encephalitis is associated with an increased risk for seizures and the development of epilepsy. We have developed a new and novel mouse model of virus-induced epilepsy. Other animal models for epilepsy use electrical stimulation or neurotoxic substances that kill and/or alter neurons within the CNS leading to spontaneous seizures. Our viral model is potentially more relevant particularly for the testing of new therapeutic strategies that use an anti-inflammatory approach. About 30% of individuals with epilepsy are refractory to existing anti-seizure medications, and recently the FDA is recommending that warnings be attached to eleven epilepsy drugs disclosing the risk of suicide. Therefore, new and novel approaches to this disease are warranted.",65714,ZRG1,Special Emphasis Panel,A1,1,329219,
7892074,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065874-01A1,,NINDS:337969;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,PEDIATRICS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"LA SPADA, ALBERT R;",1930750;,1R01NS065874,02/01/2010,01/31/2015,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; ATRA; Affect; Agonist; All-trans retinoic acid; Antimorphic mutation; Assay; Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression; Bioassay; Bioenergetic; Bioenergetics; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain region; Cataloging; Catalogs; Cell Communication and Signaling; Cell Death; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Co-Immunoprecipitations; Corpus Striatum; Corpus striatum structure; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Encephalon; Encephalons; Energy Expenditure; Energy Metabolism; FABP5; FABP5 gene; Gene Expression; Gene Targeting; Gene Transcription; Generations; Genetic; Genetic Transcription; HD protein, human; Health; Human; Human, General; Huntingtin; Huntingtin Protein; Huntingtin protein, human; Huntington Chorea; Huntington Disease; Huntington disease protein, human; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntington's disease gene product; Huntingtons Disease; IT15 protein, human; In Vitro; Intracellular Communication and Signaling; Investigation; Knock-in; Knock-in Mouse; Laboratories; Lead; Ligands; Link; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Mitochondria; Modeling; Murine; Mus; Nature; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological; Neurological Disorders; Neuron Degeneration; Neurons; Neurophysiology - biologic function; Nuclear; Nuclear Receptors; PPAR; PPAR Pathway; PPAR delta; PPARD protein; PPARdelta; Pathogenesis; Pathway interactions; Pattern; Pb element; Peroxisome Proliferator-Activated Receptor delta; Peroxisome Proliferator-Activated Receptors; Phenotype; Play; Poly Q; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Publishing; RNA Expression; Regulation; Retinoic Acid; Retinoid Binding Proteins; Retinol Binding Proteins; Retinol-Binding Protein 1; Role; Signal Transduction; Signal Transduction Systems; Signaling; Striate Body; Striatum; Subcellular Process; Targetings, Gene; Testing; Therapeutic Intervention; Time; Tissues; Trans Vitamin A Acid; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Transgenic Mice; Treatment Efficacy; Tretinoin; Tretinoinum; Vitamin A Acid; Work; all-trans-Retinoic Acid; all-trans-Vitamin A acid; base; biological signal transduction; disease phenotype; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; human Huntingtin protein; in vivo; intervention therapy; microarray technology; mitochondrial; mitochondrial dysfunction; mouse model; mutant; necrocytosis; nervous system disorder; nestin; nestin protein; neural; neural degeneration; neural function; neurodegeneration; neurodegenerative illness; neurodegenerative phenotype; neurological disease; neuron toxicity; neuronal; neuronal degeneration; neuronal toxicity; neurotoxicity; pathway; poly(glutamine); polyQ; polyglutamine; protein expression; public health relevance; relating to nervous system; research study; response; social role; striatal; therapeutic efficacy; therapeutic target; therapeutically effective; trans-Retinoic Acid; transcription factor",The PPAR-delta pathway in neural function and Hungtington's disease neuropatholog," 7. Project Narrative Studies of Huntington's disease (HD) and other related neurodegenerative disorders have highlighted the importance of mitochondrial function and bioenergetics in the maintenance of normal neural function. In this project, we will examine the exciting hypothesis that PPAR¨ is involved in the maintenance of neuronal energy generation and that altered function of PPAR¨ contributes to HD neurodegeneration. If PPAR¨ is involved in this neurological disease, then tractable therapies to boost PPAR¨ function would be tested, as highly selective and powerful pharmacological agonists for PPAR¨ have been developed and are in use in humans, and PPAR¨ mediates pro-survival signaling in response to retinoic acid.",65874,ZRG1,Special Emphasis Panel,A1,1,337969,
7694887,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065895-01,,NINDS:358750;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MARTIN, LEE J;",1882519;,1R01NS065895,02/01/2010,01/31/2015,"21+ years old; ALS; Adenine Nucleotides; Adenosine Phosphates; Adult; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Apoptosis Pathway; Atrophic; Atrophy; Attenuated; Automobile Driving; Biology; Body Tissues; Cell Culture Techniques; Cell Death, Programmed; Cell model; Cells; Cellular model; Cessation of life; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cultured Cells; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disease Progression; Disease by Site; Disorder; Disorder by Site; Disorder of muscle, unspecified; Distal; Drivings, Automobile; Environmental Factor; Environmental Risk Factor; Extremities; FRET; Familial Amyotrophic Lateral Sclerosis; Fluorescence Resonance Energy Transfer; Fluorescent Probes; Gehrig's Disease; Gene Deletion; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Variation; Genetic defect; Grant; Hereditary; Human; Human, Adult; Human, General; In Vitro; Inherited; Investigators; Ion Channel; Ionic Channels; Lead; Life; Limb structure; Limbs; Lou Gehrig Disease; MMC; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medulla Spinalis; Membrane Channels; Mice; Mice, Transgenic; Microscopy; Mitochondria; Mitochondria, Muscle; Mitochondrial Porin; Modeling; Molecular Target; Motor Cell; Motor Neuron Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Murine; Mus; Muscle; Muscle Cells, Embryonic; Muscle Cells, Precursor; Muscle Denervation; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Mitochondria; Muscle Paresis; Muscle Tissue; Muscle denervation procedure; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Diseases; Muscular Paresis; Mutation; Myoblasts; Myoneural Junction; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotubes; N element; N2 element; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neuromuscular Diseases; Neuromuscular Junction; Nitrogen; Non-Trunk; O element; O2 element; Oxidation-Reduction; Oxidative Stress; Oxygen; Palsy; Paralysed; Paresis; Pathogenesis; Pathologic; Pathologic Processes; Pathological Processes; Pathology; Pb element; Permeability; Phenotype; Plegia; Probes, Fluorescent; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Redox; Research Personnel; Researchers; Rhabdomyocyte; Role; SOD-1 protein; SOD1 gene; SOD1 gene product; Sarcosomes; Site; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Spinal Cord; System; System, LOINC Axis 4; Testing; Tissues; Toxic effect; Toxicities; Transgenic Mice; Transgenic Organisms; VDAC mitochondrial porin; VDAC proteins; Variant; Variation; Variation (Genetics); Voltage-Dependent Anion Channel; Whole-Cell Recordings; Work; adult human (21+); age dependent; age related; allelic variant; axonopathy; base; cell imaging; cellular imaging; cyclophilin D; cyclophilin-40; cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; denitration; deprivation; disease/disorder; driving; drug discovery; effective therapy; environmental risk; gene deletion mutation; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; mitochondrial; mitochondrial megachannel; mitochondrial permeability transition pore; mitochondrial pore protein; motoneuron; motor deficit; motor neuron degeneration; muscular disorder; mutant; myoneural disorder; neurodegenerative illness; neuromuscular disorder; nitration; novel; oxidation; oxidation reduction reaction; oxidative damage; paralysis; paralytic; pore forming protein VDAC; porins, mitochondria; public health relevance; social role; superoxide dismutase 1; therapeutic development; transgenic; voltage-dependent, anion-selective channels; voltage-dependent, anion-selective, channel forming protein, mitochondrial",Skeletal Muscle Mechanisms of Disease in ALS, Project Narrative Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder. This work will determine if abnormalities in skeletal muscle have causal roles in the disease mechanisms. Skeletal muscle could provide new tissue- and molecular targets for drug discovery in ALS.,65895,NOMD,Neural Oxidative Metabolism and Death Study Section,,1,358750,
7877345,R01,NS,1,,02/01/2010,01/31/2011,PAR-07-048,1R01NS065917-01A1,,NINDS:336875;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"PARDRIDGE, WILLIAM M;",1891127;,1R01NS065917,02/01/2010,01/31/2013,"4-Amino-10-methylfolic Acid; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)-; 5,6,7,8-Tetrahydrofolate[{..}]NADP+ oxidoreductase; 5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-Hydroxydopamine; 6-OHDA; Affect; Affinity; Affinity Chromatography; Age-Months; Amphetamines; Antibodies; Apomorphine; Area; Assay; BALB/c; Behavior; Bioassay; Biochemical; Biologic Assays; Biological Assay; Bioreactors; Biotechnology, Genetic Engineering; Blood; Blood - brain barrier anatomy; Blood Plasma; Blood Serum; Blood capillaries; Blood-Brain Barrier; Blotting, Western; Brain; Brain Part; Brain region; C57BL/6 Mouse; CHO Cells; CMV; COS Cells; COS-1; Capillaries; Capillary; Capillary, Unspecified; Cations; Cell Line; Cell Lines, Strains; CellLine; Cells; Cephalic; Cerebellum; Chemistry; Chimera Protein; Chimeric Proteins; Chinese Hamster; Chinese Hamster Ovary Cell; Chromatography; Chromatography / Separation Science; Chromatography, Affinity; Chronic; Clinical; Clinical Pharmacology; Cloning; Common Rat Strains; Complementary DNA; Control Groups; Corpus Striatum; Corpus striatum structure; Cranial; Culture Media, Serum-Free; Cytomegalovirus; DHFR; DNA; DNA, Complementary; Data; Degenerative Disorder; Deoxyribonucleic Acid; Development; Dihydrofolate Dehydrogenase; Dihydrofolate Reductase; Dose; Drug Delivery; Drug Delivery Systems; Drug Kinetics; Drug Targeting; Drug Targetings; Drugs; EC 1.5.1.3; ELISA; Encephalon; Encephalons; Engineering; Engineerings; Enzyme-Linked Immunosorbent Assay; Equine; Equine Species; Equus caballus; Equus przewalskii; Euthanasia; Experimental Parkinsonism; Experimental Parkinsonisms; Feasibility Studies; Female; Filtration; Folic Acid Reductase; Fractionation, Filtration; Fusion Protein; G-substrate; Gamma Globulin, 7S; Genes; Genetic Engineering; Genital System, Female, Ovary; Granulocyte/Pollen-Binding Protein; HBV; HCMV; Hamster, Chinese; Hemato-Encephalic Barrier; Hepatitis B Virus; Hepatitis Virus, Homologous Serum; Histology; Horse, Domestic; Horses; Human; Human, General; Hybridomas; INSR; INSR protein, human; Idiopathic Parkinson Disease; IgG; IgG1; Immunoglobulin G; Immunoglobulin V; Immunoglobulin Variable Region; Inbred BALB C Mice; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin-Dependent Tyrosine Protein Kinase; Intervening Sequences; Introns; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-; L-Tyrosine,tetrahydrobiopterin[{..}]oxygen oxidoreductase (3-hydroxylating); Label; Laboratories; Lesion; Lewy Body Parkinson Disease; Light; MPTP-Induced Experimental Parkinsonism; Macaca mulatta; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Medication; Mercy Killing; Methods; Methotrexate; Methotrexate Methylaminopterin; Methotrexatum; Metotrexato; Mice; Mice, Inbred BALB C; Moab, Clinical Treatment; Molecular Biology, Genetic Engineering; Monoclonal Antibodies; Mouse, BALB C; Murine; Mus; Nerve Degeneration; Nerve Growth Factor Receptors; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Neuron Degeneration; Neurotoxins; Neurotrophic Factor Receptor; Organ; Organ Weight; Ovary; Oxidopamine; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson Disease, Experimental; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Pharmacology, Clinical; Photoradiation; Plasma; Polyomavirus macacae; Polyomavirus maccacae 1; Primary Parkinsonism; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein-Free Media; Proteins; Public Health; RNA Splicing; Radio; Rat; Rattus; Reaction Time; Receptor Protein; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Recombinant DNA Technology; Research; Response RT; Response Time; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Rhesus; Rhesus Macaque; Rhesus Monkey; Rodent; Rodentia; Rodentias; Rotation; SV 40; SV 40 Virus; SV40; SV40 Virus; Salivary Gland Viruses; Science of Chemistry; Series; Serum; Serum, Plasma; Serum-Free Culture Media; Serum-Free Media; Siderophilin; Simian Vacuolating Virus 40; Simian virus 40; Splicing; Striate Body; Striatum; System; System, LOINC Axis 4; Testing; Tetrahydrofolate Dehydrogenase; Therapeutic; Therapeutic Index; Toxic effect; Toxicities; Toxin; Transferrin; Transferrin Receptor; Tyrosine 3-Monooxygenase; Tyrosine Hydroxylase; Vacuolating Agent; Variable Region; Variable Region, Ig; Weight, Organ; Western Blotting; Western Blottings; Western Immunoblotting; affinity purification; analog; behavior measurement; behavior test; behavioral measure; behavioral measurement; behavioral test; bovine growth hormone; brain cell; cDNA; capillary; cerebellum protein substrate for cGMP dependent protein kinase; cultured cell line; cytomegalovirus group; degenerative condition; degenerative disease; drug development; drug discovery; drug efficacy; drug/agent; enzyme activity; experiment; experimental research; experimental study; fusion gene; gene cloning; gene product; growth hormone, bovine; human INSR protein; human cytomegalovirus; immunocytochemistry; immunogenicity; in vivo; insulin receptor, human; light microscopy; male; molecular trojan horse; molecular trojan horse technology; mouse model; nervous system disorder; neural degeneration; neurodegeneration; neurological disease; neuronal degeneration; neurotoxicant; neurotrophic factor; neurotrophin; neutrophin; new therapeutics; next generation therapeutics; novel; novel therapeutics; plasmid DNA; pre-clinical; preclinical; protein G; protein blotting; psychomotor reaction time; public health medicine (field); public health relevance; receptor; receptor binding; research study; response; sex; somatotropin, bovine; somidobove; striatal; uptake; vacuolating virus",Neurotrophin Drug Development for Parkinson's Disease,"  RELEVANCE TO PUBLIC HEALTH Parkinson's disease (PD) affects 1 million people in the U.S. The most potent form of treatment of PD is a neurotrophin called GDNF; however, GDNF does not cross the blood-brain barrier (BBB). The present research will test in experimental PD in mice the efficacy of a new form of GDNF, wherein the neurotrophin is re-engineered as a fusion protein with a monoclonal antibody that crosses the BBB via receptor-mediated transport.",65917,ZRG1,Special Emphasis Panel,A1,1,336875,
7899610,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS065945-01A2,,NINDS:343438;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"LIPTON, HOWARD LEE;",1894997;,1R01NS065945,02/01/2010,01/31/2014,"Address; Apical; Apoptosis; Apoptosis Pathway; Apoptotic; Arm; Attenuated; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Capsid Proteins; Cardiovirus; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; Cell surface; CellLine; Cells; Cells, CD4; Central Nervous System; Central Nervous System Infections; Central Nervous System Infectious Disease; Central Nervous System Infectious Disorder; Cessation of life; Coat Proteins; D Cells; Death; Delta Cell; Demyelinating Diseases; Demyelinating Disorders; Demyelinations; Elements; Experimental Animal Model; Family Picornaviridae; Fostering; Genes, p53; Host Factor; Host Factor Protein; Immune; Immune response; Immunity; In Vitro; Infection; Inhibition of Apoptosis; Integration Host Factors; Intracellular Communication and Signaling; Killings; Lytic; MS (Multiple Sclerosis); Mammalian Cell; Mammals, Mice; Mammals, Rodents; Mediating; Mice; Mice, Transgenic; Mitochondria; Modeling; Mouse Polioviruses; Mouse Strains; Multiple Sclerosis; Murine; Mus; Necrosis; Necrotic; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Nonstructural Protein; Noxae; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Organism; P53; Pathway interactions; Phagocytosis; Picornaviridae; Picornaviruses; Polioviruses, Murine; Population; Process; Production; Protein, Nonstructural; Proteins; RNA Virus Infections; RNA Viruses; Replication Unit; Replicon; Resistance; Rodent; Rodentia; Rodentias; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Somatostatin Cells; Somatostatin Secreting Cell; System; System, LOINC Axis 4; T4 Cells; T4 Lymphocytes; TMEV; TP53; TP53 gene; TRP53; Theiler Murine Encephalomyelitis Virus; Theiler's Virus; Theiler's encephalomyelitis virus; Transgenic Mice; Tumor Protein p53 Gene; Upper arm; Viral; Viral Coat Proteins; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Outer Coat Protein; Viral Proteins; Virulent; Virus; Virus Diseases; Virus Replication; Viruses, General; Work; autoimmune disorder; bean; biological signal transduction; cultured cell line; experiment; experimental research; experimental study; extracellular; gene product; genetic variant; helper T cell; host response; immunoresponse; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; insular sclerosis; living system; macrophage; member; mitochondrial; necrocytosis; neuronal; neurovirulence; neutralizing antibody; pathway; public health relevance; research study; resistant; response; self recognition (immune); viral infection; virus infection; virus multiplication; virus protein",Theiler's virus-induced aoptosis: A mechanism for CNS virus persistence," The notion that multiple sclerosis (MS) is an autoimmune disease is widely accepted as fact. While MS is undoubtedly immune-mediated, an autoimmune mechanism remains unproven. Circumstantial evidence points to a persistent virus infection in MS. Moreover, immune- mediated damage can result from a virus infection in which the host immune response is directed to virus proteins rather than selfproteins (autoimmunity). Theiler's murine encephalomyelitis virus (TMEV) produces a persistent central nervous system infection and immune-mediated demyelination in susceptible strains of mice, providing a relevant experimental animal model for MS. TMEV persistence is needed to drive the demyelinating disease process, but just how this virus that rapidly kills infected cells is able to perpetuate the infection is not known. This proposal addresses a mechanism of TMEV persistence, programmed cell death also termed apoptosis, which decreases virus production (may be required for persistence of virulent virus) and also fosters cell-to-cell virus spread (required for persistence in the presence of host immunity).",65945,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,A2,1,343438,
7766343,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS066955-01,,NINDS:351549;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"CANOLL, PETER D;",1932135;,1R01NS066955,02/01/2010,01/31/2015,"1-Phosphatidylinositol 3-Kinase; 21+ years old; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Adult; Affect; Anti-Oncogenes; Antioncogenes; Astrocytoma, Grade IV; Autocrine Systems; BZS; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CD140B; CD140a Antigens; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Signaling; Cells; Embryo; Embryonic; Emerogenes; Encephalon; Encephalons; Environment; GFAC; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Gliomagenesis; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heterograft; Human; Human, Adult; Human, General; Intracellular Communication and Signaling; JTK12; Link; MHAM; MMAC1; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Man (Taxonomy); Man, Modern; Mice, Transgenic; Modeling; Molecular; Mother Cells; Mutation; Neonatal; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P53; PDGF; PDGF, B Chain; PDGF-2; PDGF-R-Beta; PDGF-R-alpha; PDGFB; PDGFR; PDGFR1; PDGFR2; PDGFRA; PDGFRB; PDGFRB gene; PI-3 Kinase; PI-3K; PI3-Kinase; PTEN; PTEN gene; PTEN1; Paracrine Communication; Paracrine Signaling; Pathway interactions; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Platelet Derived Growth Factor Beta Chain; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor B; Platelet-Derived Growth Factor Beta; Platelet-Derived Growth Factor Receptor Alpha Polypeptide; Platelet-Derived Growth Factor alpha Receptor; Platelet-Derived Growth Factor, B Chain; Platelet-Derived Growth Factor, Beta Polypeptide; Play; Population; Progenitor Cells; Proliferating; Proto-Oncogene Products c-sis; Proto-Oncogene Proteins c-sis; PtdIns 3-Kinase; Receptor, PDGF alpha; Recruitment Activity; Retroviridae; Retroviruses; Role; SIS Gene Product; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Transgenic Mice; Transplantation, Heterologous; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tumors of Neuroglia; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Virus-Retrovirus; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; adult human (21+); autocrine; biological signal transduction; c-sis Proteins; cell transformation; genome mutation; glioblastoma multiforme; glioma genesis; insight; malignant phenotype; migration; mutant; oncosuppressor gene; ontogeny; paracrine; pathway; progenitor; public health relevance; recruit; response; sis Proto-Oncogene Proteins; social role; spongioblastoma multiforme; substantia alba; transformed cells; tumor; tumor growth; tumor suppressor; tumorigenesis; tumorigenic; tumors in the brain; white matter",The Role of White Matter Progenitors in Glioma Formation and Progression, Project Narrative: Oligodendrocyte progenitors are one of the largest populations of cycling cells in the adult brain. These cells have an inherent capacity to proliferate massively when stimulated with platelet derived growth factor (PDGF) and genetic deletion of the tumor suppressor genes PTEN and p53 greatly facilitate their responsiveness to PDGF. Our goal is to characterize the role that adult oligodendrocyte progenitors play in the formation and progression of malignant gliomas.,66955,CMBG,Cellular and Molecular Biology of Glia Study Section,,1,351549,
7766465,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS066977-01,,NINDS:265132;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WALTHAM,UNITED STATES,BIOLOGY,07,616845814,US,MA,024549110,BRANDEIS UNIVERSITY,"BIRREN, SUSAN J;",1885141;,1R01NS066977,02/01/2010,01/31/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine; Acute; BDNF; Blood Pressure, High; Body Tissues; Brain-Derived Neurotrophic Factor; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiac Output; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cells; Death, Sudden, Cardiac; Development; Disease; Disorder; Electrophysiology; Electrophysiology (science); Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Heart; Heart Diseases; Heart failure; Heart myocyte; Human; Human, General; Hypertension; In Vitro; Individual; Intracellular Communication and Signaling; Levarterenol; Levonorepinephrine; Link; MGC34632; Man (Taxonomy); Man, Modern; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardium; Myocytes, Cardiac; NRVS-SYS; Nerve Cells; Nerve Growth Factor Receptors; Nerve Growth Factors; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neural Transmission; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuronal Transmission; Neuronotrophic Factors; Neurons; Neurophysiology / Electrophysiology; Neurotransmitters; Neurotrophic Factor Receptor; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Noradrenaline; Norepinephrine; Organ System, Cardiovascular; Output; Parasympathetic Nervous System; Pathology; Pathway interactions; Pattern; Population; Property; Property, LOINC Axis 2; Receptor Protein; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Regulation; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Synapses; Synaptic; Synaptic Transmission; System; System, LOINC Axis 4; Testing; Therapeutic; Tissues; Transmission; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Whole-Cell Recordings; biological signal transduction; cardiac failure; cardiac muscle; cardiomyocyte; cholinergic; cholinergic neuron; circulatory system; disease/disorder; experiment; experimental research; experimental study; heart disorder; heart muscle; heart output; hyperpiesia; hyperpiesis; hypertensive disease; immunocytochemistry; in vivo; neural circuit; neural circuitry; neural control; neural regulation; neuronal; neuroregulation; neurotransmission; neurotrophic factor; neurotrophin; neutrophin; new approaches; new therapeutics; next generation therapeutics; noradrenergic; novel approaches; novel strategies; novel strategy; novel therapeutics; pathway; postsynaptic; presynaptic; public health relevance; receptor; research study; response; social role; synapse function; synaptic function; transmission process",Regulation of Sympathetic Neuron Synaptic Activity," Project Narrative Heightened sympathetic drive to the heart is linked to a number of pathologies, including sudden cardiac death. In this project we will investigate mechanisms that acutely regulate the level of excitatory and inhibitory transmission in individual sympathetic neurons and test the hypothesis that interactions with target-derived neurotrophic factors can rapidly modulate the pattern of sympathetic activity and the effects of that activity on synaptic function. An understanding of these mechanisms will permit new approaches for developing therapeutics for cardiac pathologies.",66977,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,1,265132,
7767459,R01,NS,1,,01/15/2010,12/31/2010,PA-07-070,1R01NS067216-01,,NINDS:326206;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GHOSH, ANIRVAN ;",1912280;,1R01NS067216,01/15/2010,12/31/2013,"Affect; Ammon Horn; Autism; Autism, Early Infantile; Autism, Infantile; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome; Autistic Disorder; Axon; Brain; Cell Surface Proteins; Cells; Cerebroatrophic Hyperammonemia; Childhood Neurological Disorder; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cornu Ammonis; Defect; Dendritic Spines; Dentate Fascia; Dentate Gyrus; Development; Disease; Disorder; Encephalon; Encephalons; Excitatory Synapse; Fascia Dentata; Frequencies (time pattern); Frequency; Genetic Alteration; Genetic Change; Genetic defect; Glutamates; Goals; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Integral Membrane Protein; Intrinsic Membrane Protein; Kanner's Syndrome; L-Glutamate; LRR; Leucine-Rich Repeat; Link; Mental Retardation; Molecular; Morphogenesis; Morphology; Mutation; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurological Disorder in Children; Neurons; Peptide Domain; Play; Population; Probability; Property; Property, LOINC Axis 2; Protein Domains; Proteins, Cell Surface; Pyramidal neuron; Receptors, N-Methylaspartate; Regulation; Rett Disorder; Rett Syndrome; Rett syndrome (RS, RTS); Right-Handed Beta-Alpha Superhelix; Role; Series; Specific qualifier value; Specified; Spinal Column; Spine; Structure; Structure of dentate gyrus; Synapses; Synaptic; Tertiary Protein Structure; Therapeutic; Time; Transmembrane Protein; Vertebral column; backbone; cell type; dendrite spine; dentate gyrus; disease/disorder; experiment; experimental research; experimental study; extracellular; genome mutation; hippocampal; hippocampal pyramidal neuron; in vivo; mossy fiber; neuronal; postsynaptic; presynaptic; public health relevance; research study; shRNA; short hairpin RNA; small hairpin RNA; social role; synapse formation; synaptogenesis",REGULATION OF GLUTAMATERGIC SYNAPSES BY LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN," Project Narrative The goal of this project is to understand the role of a class of cell surface proteins in the establishment and function of excitatory synaptic connections. Several childhood neurological disorders, such as Autism, Rett Syndrome, and X-linked mental retardation are characterized by defects in synaptic connectivity and function. The findings of this project should guide efforts to better understand and develop therapeutic strategies for these disorders.",67216,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,1,326206,
7766588,R01,NS,1,,01/15/2010,11/30/2010,PA-07-070,1R01NS067288-01,,NINDS:326900;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,PHARMACOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"HOSHI, NAOTO ;",9758428;,1R01NS067288,01/15/2010,11/30/2014,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine; Action Potentials; Address; Affinity; Agents, Muscarinic; Arousal; Assay; Attention; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Brain; CNS plasticity; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Coagulation Factor IV; Cognition; Combining Site; Complex; DNA Sequence Rearrangement; Dissociation; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; FRET; Factor IV; Fluorescence Resonance Energy Transfer; Frequencies (time pattern); Frequency; Gamstorp-Wohlfart Syndrome; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Image; In Vitro; Intracellular Communication and Signaling; Ion Channel; Ion Channels, Potassium; Ionic Channels; Isaacs syndrome; Isaacs-Mertens Syndrome; K channel; K element; Learning; Lecithinase C; Life; Link; M Components; Measurement; Mediating; Membrane Channels; Memory; Microscopy; Modeling; Molecular; Molecular Interaction; Muscarinic Acetylcholine Receptor; Muscarinics; Mutation; Myeloma Proteins; Myokymia, Continuous; Nerve Cells; Nerve Pain; Nerve Transmitter Substances; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuromyotonia; Neuronal Plasticity; Neurons; Neurotransmitters; PIP2; Pain; Painful; Patch-Clamp Technics; Patch-Clamp Techniques; Pathway interactions; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phospholipase C; Phosphorylation; Physiologic; Physiological; Potassium; Potassium Channel; Process; Protein Phosphorylation; Pseudomyotonia; Pseudomyotonia Syndrome of Isaacs; PtIns 4,5-P2; PtdInsP2; Quantal Squander; Reactive Site; Rearrangement; Receptor Activation; Receptors, Muscarinic; Regulation; Regulatory Pathway; Reporting; Role; Scaffolding Protein; Seizure Disorder; Seizures; Signal Transduction; Signal Transduction Systems; Signaling; Syndrome of Continuous Muscle Activity; Testing; Therapeutic; Therapeutic Agents; V (voltage); Work; biological signal transduction; cholinergic; cofactor; cultured cell line; design; designing; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; genome mutation; imaging; lipophosphodiesterase I; mutant; nervous system disorder; neural plasticity; neurological disease; neuronal; neuronal excitability; neuroplasticity; pathway; phosphatidylcholine cholinephosphohydrolase; protein complex; public health relevance; research study; social role; voltage; voltage gated channel",Regulations and function of the M-channel," PROJECT NARRATIVE The present study is designed to identify regulatory mechanisms for the M-type potassium ion channel that are critical for setting nervous tone. The change in M-channel activities is related with nerve pain, epilepsy and cognition. This project will advance the understanding of these pathogenic conditions.",67288,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,1,326900,
7912610,R01,NS,1,,04/01/2010,03/31/2011,PA-07-070,1R01NS067469-01A1,,NINDS:559758;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"PAYAMI, HAYDEH ;",1891042;,1R01NS067469,04/01/2010,03/31/2015,"1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 4,4'-Bipyridinium, 1,1'-dimethyl-; Active Follow-up; Affect; Age; Aging; Animal Model; Animal Models and Related Studies; Animals; Biological; CNP; Caffeine; Candidate Disease Gene; Candidate Gene; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell model; Cellular model; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coffee; Copy Number Polymorphism; Custom; Data; Data Linkages; Development; Diathesis; Disease; Disease Progression; Disease susceptibility; Disorder; Drosophila; Drosophila genus; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Dyskinesia Syndromes; Environmental Factor; Environmental Risk Factor; Flies; Fruit Fly, Drosophila; Future; GWAS; GeneHomolog; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Techniques; Genotype; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; Idiopathic Parkinson Disease; Individual; Knowledge; Lewy Body Parkinson Disease; Linkages, Data; Man (Taxonomy); Man, Modern; Maps; Medication; Methyl Viologen; Modeling; Movement Disorder Syndromes; Movement Disorders; Nicotine; Nucleic Acid Regulatory Sequences; Occidental; Paralysis Agitans; Paraquat; Parents; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenomics; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Prevalence; Primary Parkinsonism; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Record Linkage Study; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research; Research Design; Risk; Risk Reduction; Running; SNP; SNPs; Safety; Screening procedure; Senescence; Single Nucleotide Polymorphism; Smoke; Smoking; Study Type; Technics, Genetic; Testing; Therapeutic; Translating; Translatings; Weight; analog; base; case control; clinical applicability; clinical application; clinical investigation; copy number variation; design; designing; disability; disease prevention; disease risk; disease/disorder; disease/disorder proneness/risk; disorder prevention; disorder risk; drug development; drug/agent; effective therapy; environment effect on gene; environmental risk; experiment; experimental research; experimental study; fly; follow-up; fruit fly; gene discovery; gene environment interaction; gene interaction; genetic regulatory element; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human stem cells; improved; interest; language translation; liability to disease; model organism; mutant; neurogenetics; novel; pathway; patient population; polymorphism; prevent; preventing; public health relevance; research study; screening; screenings; senescent; study design; therapeutic target; white race; whole genome association studies; whole genome association study",Pharmacogenomics of Parkinson's Disease,  PROJECT NARRATIVE This study aims to identify genes that interact with environmental compounds that may reduce the risk of developing Parkinson's disease (PD). The new knowledge will enable development of novel personalized therapeutics for PD prevention.,67469,MNG,Molecular Neurogenetics Study Section,A1,1,559758,
7565237,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS068464-01,,NINDS:339063;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PHARMACOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"TRAYNELIS, STEPHEN F.;",1891242;,1R01NS068464,02/01/2010,01/31/2014,"AMPA Receptors; ATP-protein phosphotransferase; Accounting; Address; Agonist; Ammon Horn; Binding; Binding (Molecular Function); Biochemical; Brain; C protein; C-terminal; CBP protein (citrate-binding); Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cations; Cell Communication and Signaling; Cell Signaling; Cell model; Cellular model; Central Nervous System; Chemosensitization; Chemosensitization/Potentiation; Cognition; Communication; Cornu Ammonis; Coupling; Data; EC 2.7; Elements; Encephalon; Encephalons; Event; Excitatory Synapse; Genetics-Mutagenesis; Glutamate Receptor; Glutamates; Goals; Hippocampus; Hippocampus (Brain); Hydrogen Bonding; Individual; Infection; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Kinases; L-Glutamate; L-Serine; Lead; Learning; Ligands; Long-Term Potentiation; Mediating; Membrane; Membrane Channels; Memory; Modeling; Models, Structural; Molecular Biology, Mutagenesis; Molecular Interaction; Movement; Mutagenesis; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuronal Transmission; Neurons; PKC; Pb element; Peptides; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Potentiation; Probability; Property; Property, LOINC Axis 2; Protein Kinase; Protein Kinase C; Protein Phosphorylation; Proteins; Receptor Protein; Receptors, AMPA; Recombinants; Regulation; Role; Scanning; Series; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structural Models; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Time; Transphosphorylases; Work; base; biological signal transduction; body movement; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; experiment; experimental research; experimental study; functional mimics; gene product; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hippocampal; hydroxyalkyl protein kinase; membrane structure; neuronal; neurotransmission; novel; phosphorylase b kinase kinase; polypeptide; postsynaptic; public health relevance; receptor; receptor function; research study; response; social role; stargazin; trafficking; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein",Control of AMPA receptor function by phosphorylation,,68464,BPNS,Biophysics of Neural Systems Study Section,,1,339063,
7861679,R01,NS,1,,03/01/2010,02/28/2011,PA-07-070,1R01NS069537-01,,NINDS:329848;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,NEUROSURGERY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"FERGUSON, ADAM R;",8207725;,1R01NS069537,03/01/2010,02/28/2013,"AMPA Receptors; Agonist; Ammon Horn; BDNF; Biochemical; Blotting, Western; Brain-Derived Neurotrophic Factor; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Culture Techniques; Cell Death; Cell Fractionation; Cell membrane; Chemical Fractionation; Circulatory Collapse; Common Rat Strains; Communication; Confocal Microscopy; Cornu Ammonis; Crowns; Cytoplasmic Membrane; Data; Dental crowns; Dose; Dysfunction; ELISA; Enzyme-Linked Immunosorbent Assay; FRACN; Fiber; Fractionation; Fractionation Radiotherapy; Functional disorder; Future; Genetics, in situ Hybridization; Glutamate Receptor; Glutamates; Goals; Hand; Hindlimb; Hippocampus; Hippocampus (Brain); Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Impairment; In Situ Hybridization; Injury; Intractable Pain; Intraspinal Neoplasm; Intraspinal Tumor; L-Glutamate; Lead; Learning; Leg; Link; Literature; Locomotor Recovery; MGC34632; Mammals, Rats; Mediating; Medulla Spinalis; Messenger RNA; Methods; Microscopy, Confocal; Monitor; Myelopathy, Traumatic; Natural regeneration; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neuro rehabilitation; Neurocyte; Neurons; Neurorehabilitation; Nociception; Outcome; Pain; Pain, Intractable; Painful; Patients; Pb element; Peripheral; Physiopathology; Plasma Membrane; Play; Position; Positioning Attribute; Preparation; Proteins; RNA, Messenger; RT-PCR; RTPCR; Rat; Rattus; Receptors, AMPA; Recovery; Recovery of Function; Refractory Pain; Regeneration; Research; Reverse Transcriptase Polymerase Chain Reaction; Role; Sensory; Shapes; Shock; Spinal; Spinal Canal Tumors; Spinal Canal and Spinal Cord Neoplasm; Spinal Cord; Spinal Cord Contusions; Spinal Cord Trauma; Spinal Cord transection injury; Spinal Neoplasms; Spinal Trauma; Spinal Tumors; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stimulus; Synaptic Membranes; Synaptic plasticity; Syndrome; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TNF-alpha inhibitor; Tactile; Testing; Therapeutic; Thoracic Portion of Spinal Cord; Thoracic Spinal Cord; Thoracic spinal cord structure; Time; Training; Transections, Spinal Cord; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumor of the Spinal Canal and Spinal Cord; Urination; Western Blotting; Western Blottings; Western Immunoblotting; Work; behavioral pharmacology; circulatory shock; cytokine; excitotoxicity; experiment; experimental research; experimental study; functional recovery; gene product; heavy metal Pb; heavy metal lead; hippocampal; improved; in situ Hybridization Staining Method; in vivo; inhibitor; inhibitor/antagonist; innervation; intractable pain syndrome; mRNA; micturition; motor control; necrocytosis; nerve supply; neural; neural patterning; neuronal; neuronal excitability; new therapeutic target; nociceptive; novel; pathophysiology; plasmalemma; prevent; preventing; protein blotting; public health relevance; regenerate; relating to nervous system; research study; response; reverse transcriptase PCR; social role; subcellular fractionation; therapeutic target; trafficking; tumor necrosis factor (unspecified); tumor necrosis factor-alpha inhibitor; uRNA; voiding",Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms,"  Project Narrative/Public Health Relevance Statement Spinal cord Injury (SCI) produces a devastating syndrome that is characterized by loss of motor control and mobility, as well as sensory dysfunction and pain. The proposed project explores cellular mechanisms that regulate a form of spinal cord learning that is thought to contribute to recovery of function after SCI. These studies may provide a novel target for improving recovery after SCI.",69537,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,1,329848,
7852561,R01,NS,1,,01/19/2010,12/31/2010,PA-07-070,1R01NS069628-01,,NINDS:342606;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BURLINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"TEUSCHER, CORY ;",2456304;,1R01NS069628,01/19/2010,12/31/2014,"1H-Imidazole-4-ethanamine; Adjuvant; Affect; Alleles; Allelomorphs; Allergy; Amines; Amino Acids; Arrestins; Autoimmune; Autoimmune Diseases; Autoimmune Process; Bears; Bordetella pertussis; Bordetella pertussis Bacterium; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CNS Diseases; CNS disorder; CSAIDS Binding Protein; CSBP; CTLA-8; CTLA8; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Cell surface; Cells; Cells, CD4; Central Nervous System Diseases; Central Nervous System Disorders; Chaperone; Chimera Protein; Chimeric Proteins; Complement; Complement Proteins; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Demyelinating Disease of Central Nervous System; Demyelinating Disorder of Central Nervous System; Development; Diathesis; Disease; Disease Resistance; Disease susceptibility; Disorder; EAE; EC 2.7.2-; Encephalomyelitis; Encephalomyelitis, Allergic; Endoplasmic Reticulum; Enhancers; Ergastoplasm; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Exposure to; Extracellular Signal-Regulated Kinases; Fusion Protein; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein Signaling Pathway; G-Protein-Coupled Receptors; G-Proteins; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Cluster; Gene Transfer Techniques; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Haemophilus pertussis; Histamine; Histamine H1 Receptors; Histamine-Sensitizing Factor; Hypersensitivity; IAP Pertussis Toxin; IFN; IL-17; IL-17A; IL17; IL17 Protein; IL17A; Immune; Immune Function, Cellular; Immune response; In Vitro; Inbred Strains Mice; Inflammation Mediators; Inflammatory; Interferons; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Intracellular Communication and Signaling; Islet-Activating Protein; Knowledge; Lead; Ligand Binding; Link; Linkage Disequilibrium; Linkage Disequilibriums; Lymphocytosis-Promoting Factor; MAP Kinase 14; MAP Kinase Mxi2; MAP kinase; MAPK; MAPK14 protein, human; MAX-Interacting Protein 2; MOG glycoprotein; MS (Multiple Sclerosis); Mammals, Mice; Maps; Mediating; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase p38Alpha; Mitogen-Activated Protein Kinases; Modeling; Molecular Chaperones; Multiple Sclerosis; Murine; Mus; Mutation; Myeloencephalitis; Pathway interactions; Pb element; Peptides; Pertussigen; Pertussis Toxin; Phenotype; Play; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Process; Production; Receptor Activation; Receptor Signaling; Receptors, H1; Receptors, Histamine H1; Regulation; Resistance; Resistance, Disease; Role; SJL/J Mouse; Sclerosis, Disseminated; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway from G-Protein Families; Stress-Activated Protein Kinase 2A; Surface; Susceptibility; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Thymus-Dependent Lymphocytes; Transfection; Transgenesis; Ursidae; Ursidae Family; aminoacid; autoimmune disorder; autoimmune encephalomyelitis; biological signal transduction; central nervous system demyelinating disorder; cytokine; disease/disorder; disease/disorder proneness/risk; experiment; experimental research; experimental study; gene cloning; genome mutation; heavy metal Pb; heavy metal lead; helper T cell; host response; human MAPK14 protein; immune function; immunoresponse; in vivo; insular sclerosis; liability to disease; loss of function; mouse model; mutant; myelin oligodendrocyte glycoprotein; new therapeutics; next generation therapeutics; novel; novel therapeutics; oligodendrocyte-myelin glycoprotein; overexpression; p38 MAP Kinase; p38 MAPK; p38 Mitogen Activated Protein Kinase; p38Alpha EXIP; pathway; polymorphism; protein activation; protein folding; public health relevance; receptor expression; research study; resistance to disease; resistant; resistant disease; resistant to disease; restoration; social role; thymus derived lymphocyte; trafficking",H1R Signaling and Immune Deviation in EAE," PROJECT NARRATIVE The function of G-protein coupled receptors (GPCRs) such as the histamine H1 receptor (H1R) can be regulated by their subcellular localization and the signaling pathways they elicit. Proper folding and cell surface expression of GPCRs is required for ligand binding and signaling. Mutations that lead to improper folding and/or intracellular trafficking comprise the largest class of GPCR mutations that result in disease. Our finding that H1R alleles controlling susceptibility to autoimmune disease exhibit differential cell surface expression and altered intracellular trafficking, with the resistant allele being retained within the endoplasmic reticulum, was the first demonstration that polymorphisms influencing GPCR trafficking and cell surface expression can regulate immune functions. Understanding the mechanisms leading to differences in the trafficking and cell surface expression of the H1R alleles, and how they can be manipulated in vivo using this naturally occurring mouse model, will undoubtedly aid in the development of new therapeutic strategies for diseases in which gain- or loss-of-function mutants leading to GPCR misfolding and/or improper intracellular trafficking are implicated.",69628,ZRG1,Special Emphasis Panel,,1,342606,
7863492,R01,NS,1,,04/01/2010,03/31/2011,PA-07-070,1R01NS069719-01,,NINDS:632335;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"RASKIND, WENDY H;",1930761;,1R01NS069719,04/01/2010,03/31/2014,"3' Splice Site; AD3-like protein; AD3LP; Abbreviations; Abnormal Movements; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Arts; Ataxia; Ataxy; Benign; Bio-Informatics; Bioinformatics; Biology; Bone marrow failure; CNP; Candidate Disease Gene; Candidate Gene; Cerebellar Ataxia; Cerebellar Incoordination; Charcot Marie Disorder; Charcot Marie Muscular Atrophy; Charcot Marie Tooth Disorder; Charcot Marie Tooth muscular atrophy; Charcot-Marie Disease; Charcot-Marie-Tooth; Charcot-Marie-Tooth Disease; Charcot-Marie-Tooth neuropathy; Chorea; Choreic Movement; Choreiform Movement; Clinic; Clinical; Code; Coding System; Collection; Comparative Genome Hybridization; Coordination Impairment; Copy Number Polymorphism; DNA; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Deposit; Deposition; Detection; Disease; Disorder; Disorder of muscle, unspecified; Dyskinesia Syndromes; Dyskinesias; Dyskinetic syndrome; Dyssynergia; Epidemiology, Family Medical History; Evaluation; Exons; Facial Myokymias; Familial Dementias; Family; Family Medical History; Family history of; Family member; Frontotemporal Dementia; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genome; Genome, Human; Genomics; Genotype; Goals; HMSN Type V; HMSN V (Hereditary Motor and Sensory Neuropathy Type V); Hereditary Disease; Hereditary Motor-Sensory Neuropathy with Pyramidal Signs; Hereditary Neuralgic Amyotrophy; Hereditary Spastic Paraplegia; History; Human; Human Genome; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hybridization Array; Hybrids; Idiopathic Parkinson Disease; Infrastructure; Investigators; Late Onset Alzheimer Disease; Lewy Body Parkinson Disease; Link; Linkage Analysis; MT-bound tau; Man (Taxonomy); Man, Modern; Methods; Methods and Techniques; Methods, Other; Molecular Disease; Molecular Genetic; Molecular Genetics; Morbidity; Morbidity - disease rate; Motor; Movement; Movement Disorder Syndromes; Movement Disorders; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Mutation; Myokymias, Facial; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Nerve Degeneration; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Neuron Degeneration; Neuropathy; Nucleotides; ORFs; Open Reading Frames; PNS Diseases; PS2 protein (alzheimer-associated); PSEN1; PSEN2; Pancytopenia; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Paroxysmal Dystonia; Participant; Pathway interactions; Peripheral Nerve Diseases; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Peroneal Muscular Atrophy; Persons; Phase; Phenotype; Polymorphism, Single Base; Predisposition; Primary Lateral Sclerosis; Primary Parkinsonism; Primary Senile Degenerative Dementia; Progranulin; Progressive Chorea, Hereditary, Chronic (Huntington); Protein Coding Region; Proteins; Publishing; RNA Splicing; Recording of previous events; Relative; Relative (related person); Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resolution; Resources; Role; S182 protein; SNP; SNPs; Sampling; Sclerosis, Lateral; Sensory; Sensory Ataxias; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism in Coding Sequence; Single Nucleotide Polymorphisms in cDNA Sequences; Site; Spastic Paraplegia, Hereditary; Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy; Spinocerebellar Ataxias; Spinocerebellar Ataxias, Dominantly-Inherited; Spinocerebellar Atrophies; Splice Acceptor Sites; Splicing; Susceptibility; Tauopathies; Techniques; Technology; Therapeutic Intervention; Type V Hereditary Motor and Sensory Neuropathy; Universities; Validation; Variant; Variation; Washington; aging population; base; body movement; brachial plexus neuropathy, hereditary; cSNP; case control; clinical data repository; clinical data warehouse; comparative genomic hybridization; comparative genomics; copy number variation; data repository; database of Genotypes and Phenotypes; dementia of the Alzheimer type; disease control; disease/disorder; disorder control; exome; experience; family based linkage study; frontotemporal lobar dementia; gene discovery; gene product; genetic disorder; genetic linkage analyses; genetic linkage analysis; genetic variant; genome mutation; genome-wide; hereditary disorder; innovate; innovation; innovative; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; intervention therapy; linkage analyses; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; muscular disorder; nervous system disorder; neural degeneration; neuritis with brachial predilection; neurodegeneration; neurogenetics; neurological disease; neuronal degeneration; neuropathic; new approaches; next generation; non-alzheimer dementia; nonalzheimer dementia; novel; novel approaches; novel strategies; novel strategy; pathway; positional cloning; presenilin 1 protein; presenilin 2 protein; presenilin-1; presenilin-2; primary degenerative dementia; public health relevance; relational database; reverse genetics; senile dementia of the Alzheimer type; social role; surveillance study; tau; tau Proteins; tau associated neurodegeneration; tau associated neurodegenerative process; tau factor; tau induced neurodegeneration; tau mediated neurodegeneration; tau neurodegenerative disease; tau neuropathology; tauopathic neurodegenerative disorder; tauopathy",Next Generation gene discovery in neurogenetics," Project Narrative The goal of this proposal is to identify novel genes that are responsible for mendelian neurogenetic disorders, including ataxias, neuropathies, myopathies, movement disorders, and highly penetrant familial dementia. We will employ newly available powerful comparative genomic array hybridization, targeted capture and massively parallel sequencing of all protein coding regions in the human genome, and bioinformatics techniques to detect causative mutations in families where the number of available affected persons is too few for linkage analyses. This new approach can rapidly identify the causes of many rare genetic diseases in humans.) )",69719,MNG,Molecular Neurogenetics Study Section,,1,632335,
7862247,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS069842-01,,NINDS:415406;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"JEGLA, TIMOTHY J;",1909604;,1R01NS069842,02/01/2010,01/31/2015,"5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-; Acute; Address; Affect; Alleles; Allelomorphs; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Anti-epileptic; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Attention; Biochemical; Biological Models; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Characteristics; Clinical; Compensation; Cornu Ammonis; Cre recombinase, mouse; Development; EEG; Electroencephalography; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Epileptogenesis; Evolution; Family; Financial compensation; Fore-Brain; Forebrain; Gene Family; Gene Transcription; Generalized seizures; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Individual; Intracellular Communication and Signaling; Ion Channel; Ion Channels, Potassium; Ionic Channels; K channel; K element; Knock-out; Knockout; Knockout Mice; Knowledge; Lead; Leptazole; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane Channels; Membrane Potentials; Mice; Mice, Knock-out; Mice, Knockout; Model System; Modeling; Models, Biologic; Murine; Mus; Mutation; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurons; Null Mouse; Pattern; Pb element; Pentamethylenetetrazole; Pentetrazole; Pentylenetetrazol; Pentylenetetrazole; Phenotype; Physiologic; Physiological; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Potassium; Potassium Channel; Predisposition; Property; Property, LOINC Axis 2; Prosencephalon; Protein Trafficking; Pyramidal neuron; Quelling; R01 Mechanism; R01 Program; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RPG; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resistance; Rest; Resting Potentials; Retrieval; Role; Seizure Disorder; Seizures; Sequence-Specific Posttranscriptional Gene Silencing; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Surface; Susceptibility; System; System, LOINC Axis 4; Testing; Therapeutic; Traffickings, Protein; Transcription; Transcription, Genetic; Transmembrane Potentials; V (voltage); Voltage-Gated K+ Channels; Voltage-Gated Potassium Channel; Work; biological signal transduction; design; designing; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gain of function; genome mutation; heavy metal Pb; heavy metal lead; hippocampal; hippocampal pyramidal neuron; human disease; in vivo; inhibitor; inhibitor/antagonist; insight; model organism; mouse Cre recombinase; mouse model; mutant; nervous system disorder; neurological disease; neuronal; neuronal excitability; novel; overexpression; protein function; protein transport; public health relevance; research study; resistant; small molecule; social role; therapeutic target; tool; trafficking; voltage","Characterization of a novel animal model of epilepsy, the Kv12.2 -/- mouse", PROJECT NARRATIVE We have developed a novel and unique animal model of epilepsy by knocking out the potassium channel Kv12.2 in the mouse. The research in this proposal is designed explore the role of Kv12.2 in neuronal signaling in order to understand how loss of this potassium channel leads to seizure susceptibility and epilepsy. This research will provide valuable new insights into mechanisms of seizure control and thus addresses a critical need for new clinical strategies for the control of epilepsy.,69842,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,1,415406,
7863432,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS069847-01,,NINDS:370141;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"BURSTEIN, RAMI ;",1971035;,1R01NS069847,02/01/2010,01/31/2015,"1H-Imidazole-4-ethanamine; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; Ablation; Animals; Applications Grants; Area; Axon; Axon Terminals; Behavioral; Benzenaminium, 4-((4-(dimethylamino)phenyl)(4-(dimethyliminio)-2,5-cyclohexadien-1-ylidene)methyl)-N,N,N-trimethyl-, dichloride; Biology; Brain; Cell Body; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cephalalgia; Cephalgia; Cephalic; Cephalodynia; Cephalodynias; Characteristics; Chemicals; Circadian Rhythms; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Cone; Cones (Eye); Cones (Retina); Cranial; Cranial Nerve II; Cranial Pain; Data; Dendrites; Diurnal Rhythm; Dopamine; Dorsal; Dura; Dura Mater; Dysfunction; Encephalon; Encephalons; Enteramine; Environment; Epileptiform Neuralgia; Exhibits; Exposure to; Eye; Eyeball; Fiber; Figs; Figs - dietary; Fothergill Disease; Fothergill's neuralgia; Functional disorder; Ganglion Cells (Retina); Goals; Grant Proposals; Grants, Applications; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Head Pain; Headache; Headache, Migraine; Hippophaine; Histamine; Hydroxytyramine; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Individual; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Label; Lateral Posterior Nucleus; Lateral Posterior Thalamic Nucleus; Lateral posterior nucleus of thalamus; Learning; Life; Light; Light Activity; Light Exercise; Light Green; Light Sensitivity; Mammals, Rats; Manuscripts; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Meningeal; Method LOINC Axis 6; Methodology; Methyl Green; Migraine; Molecular; Nerve; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neuromodulator; Neurons; Nociception; Nociceptors; Nyctohemeral Rhythm; Optic Nerve; Pain; Painful; Pathway interactions; Pattern; Perception; Peripheral; Persons; Photophobia; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Photosensitiveness due to sun; Photosensitivity; Physiopathology; Play; Position; Positioning Attribute; Posterior Nuclear Complex; Posterior Nuclear Complices; Posterior Thalamic Nuclear Group; Posterior Thalamic Nuclei; Presynaptic Terminals; Pupil light reflex; Radiation, Visible; Radiation, Visible Light; Rat; Rattus; Reaction; Relative; Relative (related person); Resolution; Response Latencies; Retina; Retinal; Retinal Cone; Retinal Ganglion Cells; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Rods and Cones; Role; Second Cranial Nerve; Sensory; Serotonin; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Somatosensory Cortex; Stimulus; Symptoms; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Tag; Testing; Thalamic structure; Thalamus; Tic Douloureux; Time; Tracer; Transmission; Trifacial Neuralgia; Trigeminal Neuralgia; Trigeminal Pain; Trigeminal System; Twenty-Four Hour Rhythm; Vertebrate Photoreceptors; Visible Light; Visible Radiation; Visual; Visual Cortex; Visual Receptor; Visually Impaired Persons; Work; allodynia; base; biological signal transduction; blind; blind individual; blind people; blind person; cell body (neuron); central sensitization; circadian; circadian process; cone cell; cone-rod degneration; daily biorhythm; diurnal variation; dorsal horn; experience; hypocretin; hypocretin/orexin; hypocretins/orexins; imaging; in vivo; innervation; insight; light intensity; melanopsin; nerve supply; neural; neural cell body; neural mechanism; neural tract; neuromechanism; neuronal; neuronal cell body; neuronal patterning; nociceptive; noradrenergic; novel; orexin; pathophysiology; pathway; photoactivation; public health relevance; pupillary light reflex; pupillary reflex; relating to nervous system; response; retinal axon; retinal ganglion; rod cell; rod-cone degeneration; sensory cortex; social role; soma; somatosensory; somesthetic sensory cortex; sun sensitivity; thalamic; transmission process; trifocal neuralgia; trigeminal; visual cortical; visually impaired people",Migraine pathophysiology: neural basis of photophobia, PROJECT NARRATIVE Almost every person undergoing a migraine attack seeks sanctuary in a dark environment in order to lessen the intensification of headache caused by exposure to light. This grant proposal will test a novel hypothesis that migraine headache is exacerbated by non-image-forming signals from the retina that are incorporated in the thalamus by nociceptive neurons that project to cortical areas involved in pain perception. This application could potentially open a unique window into the biology of an adverse phenomenon described by millions of headache sufferers.,69847,SCS,Somatosensory and Chemosensory Systems Study Section,,1,370141,
7856804,R01,NS,1,,02/01/2010,01/31/2011,PA-07-070,1R01NS070001-01,,NINDS:389375;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"LIAO, JAMES KUANG-JAN;",1864683;,1R01NS070001,02/01/2010,01/31/2015,"1-(5-isoquinolinesulfonyl)homopiperazine; 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-; 280 kDa actin-binding protein; 3-hydroxy-3-methylglutaryl coenzyme A Inhibitors; ABP 280; Actins; Acute; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adhesions; Affect; Agonist; Apoplexy; Arteriosclerosis; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bizzozero's corpuscle/cell; Blood Clot; Blood Clotting; Blood Coagulation Factor IV; Blood Platelets; Blood Pressure, High; Blood Vessels; Blood coagulation; Blood flow; Blood leukocyte; Body Tissues; Bone Marrow Transplant; Bone Marrow Transplantation; CNOS; Ca++ element; Calcium; Carotid Arteriopathies, Traumatic; Carotid Artery Injuries; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Matrix; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Clotting; Coagulation; Coagulation Factor IV; Coagulation Process; Constitutive NOS; Coronary Artery Vasospasm; Coronary Vasospasm; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal System; Cytoskeleton; Data; Death; Deetjeen's body; Development; Disease; Disorder; Dysfunction; EC 2.7; ECNOS; ENOS; Electron Microscopy; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Event; Extracellular Matrix, Integrins; Factor IV; Filament; Functional disorder; Generations; Genetic; Goals; Grafting, Bone Marrow; HMG-CoA Reductase Inhibitors; Hayem's elementary corpuscle; Homo; Human; Human, General; Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; INFLM; Imagery; In Vitro; Infarction; Inflammation; Inflammatory; Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase; Inhibitors, Hydroxymethylglutaryl-CoA; Inhibitors, Hydroxymethylglutaryl-Coenzyme A; Integrins; Intracellular Communication and Signaling; Ischemic Stroke; Isoforms; Kinases; Knock-out; Knockout; Knockout Mice; LIM Domain Kinase 1; LIM kinase; LIMK protein; LIMK-1; LIMK1; Lead; Leukocytes; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Marrow leukocyte; Marrow platelet; Measurement; Mediating; Methods; Mice; Mice, Knock-out; Mice, Knockout; Middle Cerebral Artery Occlusion; Modeling; Murine; Mus; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Necrosis; Necrotic; Neuronal Injury; Nitric Oxide Synthase 3; Null Mouse; Occlusion, Middle Cerebral Artery; P160ROCK; PKA; Pathway interactions; Patients; Pb element; Phosphotransferases; Physiopathology; Platelet Activation; Platelet aggregation; Platelets; Play; Production; Protein Isoforms; Protein Kinase A; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; ROCK1; ROCK1 gene; Receptor Protein; Research; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Platelets; Rho-associated kinase; Rho-kinase; Role; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Statins, HMG-CoA; Stroke; Structure; Technology; Testing; Threonine Kinase; Thrombase; Thrombin; Thrombocytes; Thrombosis; Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Thromboxane A2; Thrombus; Tissues; Transphosphorylases; Trauma, Carotid Artery; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Visualization; WHBLOOD; White Blood Cells; White Cell; Whole Blood; atheromatosis; atherosclerotic vascular disease; biological signal transduction; brain attack; cAMP-Dependent Protein Kinases; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; disability; disease/disorder; eNOS enzyme; endothelial constitutive nitric oxide synthase; fasudil; fibrinogenase; filamin; filamin 1; filamin A; heavy metal Pb; heavy metal lead; human NOS3 protein; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; infarct; inhibitor; inhibitor/antagonist; intracellular skeleton; loss of function; mouse model; neuron injury; neurovascular unit; novel; pathophysiology; pathway; prevent; preventing; public health relevance; receptor; response; rho; social role; stroke; therapeutic target; thrombocyte/platelet; vascular; vascular inflammation; white blood cell; white blood corpuscle",Novel Signaling Pathways in Ischemic Stroke," Stroke is the 3rd leading cause of death and a major cause of disability in the Western society. The final common pathway of most strokes is platelet activation and aggregation. This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in platelets as a potential therapeutic target for preventing and treating ischemic strokes.",70001,ANIE,Acute Neural Injury and Epilepsy Study Section,,1,389375,
7879078,R01,NS,1,,04/01/2010,03/31/2011,PA-07-070,1R01NS070644-01,,NINDS:322444;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,BIOCHEMISTRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"MANN, RICHARD S;",1902259;,1R01NS070644,04/01/2010,03/31/2015,"21+ years old; Active Follow-up; Address; Adult; Afferent Neurons; Aging; Animals; Assay; Axon; Behavior; Bioassay; Biologic Assays; Biological Assay; Biological Models; Candidate Disease Gene; Candidate Gene; Cell Body; Central Nervous System; Characteristics; Code; Coding System; Complement; Complement Proteins; Complex; DNA Molecular Biology; Date of birth; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Drosophila; Drosophila genus; Drosophila melanogaster; Dysfunction; Embryo; Embryonic; Feedback; Flies; Fruit Fly, Drosophila; Functional disorder; Funding; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Genetic; Genetic Models; Genetic Screening; Goals; Hand; Human, Adult; Learning; Leg; Length of Life; Locomotion; Longevity; Mind; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular Biology; Monitor; Mother Cells; Motor; Motor Cell; Motor Neurons; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscular Contraction; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neurons, Afferent; Neurons, Sensory; Organ; Paper; Physiopathology; Play; Profilings, Gene Expression; Progenitor Cells; Publishing; Role; Senescence; Sensory; Sensory Cell Afferent Neuron; Specific qualifier value; Specified; Stem cells; System; System, LOINC Axis 4; Testing; Time; Transcript Expression Analyses; Transcript Expression Analysis; Vertebrate Animals; Vertebrates; Walking; Work; adult human (21+); appendage; base; cell body (neuron); combinatorial; feeding; fly; follow-up; fruit fly; genetic manipulation; life span; lifespan; motoneuron; motor neuron development; nervous system development; neural cell body; neural circuit; neural circuitry; neurodegenerative illness; neuromotor system; neuromuscular; neuromuscular system; neuronal; neuronal cell body; novel; pathophysiology; public health relevance; senescent; sensory feedback; sensory system; social role; soma; tool; transcription factor; vertebrata",Development and function of an adult locomotion circuit in Drosophila," Animal locomotion requires the coordinated firing of motor neurons that trigger the contraction of muscles in the appendages, such as the legs. This project will investigate the development and function of the motor circuit used by the adult fruit fly for walking. The use of this model system will help to decipher the genes and neurons required for coordinated locomotion and, therefore, the eventual treatment of motor neuron-related dysfunction resulting from neurodegenerative diseases and aging.",70644,DEV2,Development - 2 Study Section,,1,322444,
7773565,R03,AG,1,,02/01/2010,01/31/2011,PA-06-180,1R03AG035228-01,,NIA:62115;,2010,NATIONAL INSTITUTE ON AGING,,BOULDER,UNITED STATES,CHEMISTRY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"TAATJES, DYLAN J;",6275624;,1R03AG035228,02/01/2010,01/31/2012,"Affect; Age; Aging; Aging, Premature; Animals; Antioncogene Protein p53; Biochemical; Cancers; Cells; Cellular Tumor Antigen P53; Chimera Protein; Chimeric Proteins; DNA Binding; DNA Binding Interaction; Disease; Disorder; Fusion Protein; Future; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genes, p53; Genetic Transcription; HCT 116 Cells; HCT116; HCT116 Cells; HDM2; HDM2 protein; Heart; Human; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Insecta; Insects; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Invertebrates, Insects; Isoforms; Knock-in; Knock-in Mouse; Lead; Length; Length of Life; Link; Longevity; MDM 2 Protein; MDM2; MDM2 protein, human; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Messenger RNA; Mice; Modeling; Molecular; Murine; Mus; Oncoprotein p53; Organism-Level Process; Organismal Process; P53; Pb element; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Physiologic Processes; Physiological Processes; Play; Premature aging syndrome; Process; Protein Isoforms; Protein TP53; Protein p53; Proteins; RNA Expression; RNA, Messenger; Refractory; Regulation; Relative; Relative (related person); Repression; Research; Role; Senescence; Series; Somatomedin C; Staging; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Time; Transcription; Transcription Activation; Transcription Corepressor; Transcription Regulation; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Ubiquitin-Protein Ligase E3 MDM2; Up-Regulation; Work; age dependent; age related; base; cancer prevention; design; designing; dimer; disease/disorder; double minute 2 protein; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; human MDM2 protein; human disease; human double minute 2 protein; insight; life span; lifespan; mRNA; malignancy; mutant; neoplasm/cancer; overexpression; p53 Antigen; p53 Binding Protein; p53 Tumor Suppressor; p53-Binding Protein MDM2; prevent; preventing; public health relevance; reconstitute; reconstitution; research study; response; senescent; social role; transcription factor; tumor suppressor",Biochemical Analysis of a p53 Isoform that Accelerates Mammalian Aging," Our research analyzes the basic mechanisms of gene expression-what turns a gene ""on"" or ""off"" in a cell. Understanding this process is vital because proper regulation of gene expression is essential for virtually every major physiological process; furthermore, breakdown in this regulation is a hallmark of human disease, most notably cancer. In this proposal we will examine the function of an improperly activated protein called p53. Understanding how p53 functions, particularly in its abnormal, ""hyper-active"" state, lies at the heart of the cancer and aging problem because the form of p53 we are studying shows enhanced ability to prevent cancer yet concomitantly shortens lifespan. The precise mechanisms by which this occurs are not at all understood and will be explored in this study. We anticipate that the information accumulated by our efforts will identify new strategies for controlling the transcriptional activity of p53.",35228,CMAD,Cellular Mechanisms in Aging and Development Study Section,,1,62115,
7872640,R03,AI,1,,02/01/2010,01/31/2011,PA-09-163,1R03AI088042-01,,NIAID:80000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"SINGH, UPINDER ;",1950672;,1R03AI088042,02/01/2010,01/31/2012,"Amebiasis; Amoeba; Amoeba genus; Area; Assay; Award; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Models; Biological Process; Biology; Blotting, Western; Body Tissues; C-terminal; Candidate Disease Gene; Candidate Gene; Causality; Clinical; Communities; Cyst; Data; Development; Developmental Biology; Disease; Disorder; Double-Stranded RNA; Down-Regulation; Down-Regulation (Physiology); Downregulation; E. histolytica; E. invadens; E.invadens; Endamoeba histolytica; Entamoeba; Entamoeba histolytica; Entamoeba invadens; Etiology; GWAS; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gene Expression; Gene Inactivation; Gene Proteins; Gene Silencing; Genes; Genetic; Health; Human; Human, General; Immune Precipitation; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Immunoprecipitation; In Vitro; Infection; Intestinal Diseases; Intestinal Disorder; Investigators; Life Cycle; Life Cycle Stages; Man (Taxonomy); Man, Modern; Measures; Methods; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Molecular; Nucleic Acid Regulatory Sequences; Overexpression; Parasites; Pathway interactions; Pattern; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Gene Products; Protein Overexpression; Proteins; RNA, Double-Stranded; Reagent; Regulator Regions, Nucleic Acid; Regulatory Pathway; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reptiles; Reptilia; Research; Research Personnel; Research Resources; Researchers; Resources; Staging; Study models; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Therapeutic Intervention; Time; Tissues; Transfection; Western Blotting; Western Blottings; Western Immunoblotting; Work; base; communicable disease transmission; disease causation; disease etiology; disease transmission; disease/disorder; disease/disorder etiology; disorder etiology; dsRNA; excystation; gastrointestinal disorder; gene product; genetic manipulation; genetic regulatory element; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human disease; infectious disease transmission; insight; interest; intervention therapy; intestine disorder; life course; member; method development; new diagnostics; next generation diagnostics; novel diagnostics; overexpress; overexpression; pathogen; pathway; prevent; preventing; protein blotting; public health relevance; shRNA; short hairpin RNA; small hairpin RNA; tool; tool development; vector; whole genome association studies; whole genome association study",Developing tools for genetic manipulation in Entamoeba invadens," Project Narrative Entamoeba histolytica is an important pathogen with an impact on human health on a global scale. Conversion between the two life cycle stages is crucial to disease transmission; however, this area of parasite biology is poorly understood. We are interested in understanding the molecular mechanisms that the parasite uses to convert between life cycle stages.",88042,ZRG1,Special Emphasis Panel,,1,80000,
7772393,R03,DA,1,,02/01/2010,01/31/2011,PAS-07-327,1R03DA027849-01,,NIDA:194635;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,MISCELLANEOUS,08,001423631,US,MA,02115,NORTHEASTERN UNIVERSITY,"TIBURU, ELVIS K;",8079426;,1R03DA027849,02/01/2010,01/31/2012,"2-arachidonoyl-glycerol; 2-arachidonoylglycerol; 2-arachidonyl-glycerol; 2-arachidonylglycerol; 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-; 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)-; 5,8,11,14-eicosatetraenoylethanolamide; 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-; 9-ene-Tetrahydrocannabinol; Addiction, Drug; Adverse effects; Affinity; Aggregated Data; Aggregation, Data; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Aminoethanols; Architecture; Behavioral; Binding; Binding (Molecular Function); Biochemical; Bone remodeling; Boston; Brain; CB2 Receptor; Cannabinoids; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Central Nervous System; Chemical Dependence; City of Boston; Clinic; Complementary DNA; Complex; Coupling; Cysteine; Cytoplasm; Cytoplasmic Membrane; DNA Sequence Rearrangement; DNA, Complementary; Data; Data Aggregation; Delta-9-Tetrahydrocannabinol; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence, Drug; Detergents; Disease; Disorder; Dronabinol; Drug Addiction; Drug Dependency; Drug or chemical Tissue Distribution; E coli; Encephalon; Encephalons; Endocannabinoids; Engineering / Architecture; Environment; Enzymes; Escherichia coli; Ethanolamines; Event; FAAH protein; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Glycerol Monoester Hydrolases; Glycerol-ester acylhydrolase; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Half-Cystine; Hematopoietic; Homology Modeling; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hydrolysis; INFLM; Immune response; Immunocompetent; Inflammation; Intracellular Communication and Signaling; Knowledge; L-Cysteine; Label; Length; Ligands; Link; Lipids; Man (Taxonomy); Man, Modern; Marinol; Marketing; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medical; Membrane; Metabolic syndrome; Methods and Techniques; Methods, Other; Micelles; Models, Molecular; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Models; Molecular Stereochemistry; Monoacylglycerol Lipases; Monoglyceride Esterases; Monoglyceride Hydrolase; Monoglyceride Lipases; N arachidonoyl 2 hydroxyethylamide; N-(2-hydroxyethyl)arachidonamide; Nervous System, Brain; Nervous System, CNS; Neuraxis; Nucleic Acid Biochemistry, Molecular Modeling; Obesity; Organism-Level Process; Organismal Process; Osteoblasts; Osteoclasts; Over weight; Overweight; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pathologic Processes; Pathological Processes; Peptides; Phosphatides; Phospholipids; Photometry/Spectrum Analysis, Mass; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Plants; Plants, General; Plasma Membrane; Primary Senile Degenerative Dementia; Progressive Chorea, Hereditary, Chronic (Huntington); Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Rearrangement; Receptor Activation; Receptor Protein; Receptor, Cannabinoid, CB2; Relative; Relative (related person); Research; Rhodopsin; Risk; Roentgen Rays; Signal Transduction; Signal Transduction Systems; Signaling; Sodium Chloride; Sodium chloride (NaCl); Solutions; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stimulus; Structure; Study models; Substance abuse problem; System; System, LOINC Axis 4; Techniques; Tetrahydrocannabinol; Therapeutic; Tissue Distribution; Transmission; Treatment Side Effects; Universities; Visual Purple; Weight Loss Agents; Weight-Loss Drugs; Work; X-Radiation; X-Rays; Xrays; abuse of substances; adiposity; anandamide; anandamide (20.4,n-6); arachidonoyl ethanolamide; arachidonoylethanolamide; arachidonylethanolamide; base; biological signal transduction; bone remodelling; cDNA; cannabinoid receptor; conformation; conformational state; corpulence; corpulency; corpulentia; delta(1)-THC; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; dementia of the Alzheimer type; design; designing; disease/disorder; drug candidate; drug discovery; experiment; experimental research; experimental study; extracellular; fatty acid amide hydrolase; gene product; host response; immunoresponse; inflammatory neuropathic pain; membrane model; membrane structure; molecular modeling; novel; obese; obese people; obese person; obese population; oleamide hydrolase; plasmalemma; polypeptide; primary degenerative dementia; professor; protein structure; public health relevance; receptor; research study; response; salt; senile dementia of the Alzheimer type; side effect; small molecule; solid state nuclear magnetic resonance; substance abuse; therapy adverse effect; transmission process; treatment adverse effect","Ligand-Assisted Structural Studies of the Human Cannabinoid Receptor 2, Using NMR"," OTHER PROJECT INFORMATION - SECTION 7 - PROJECT NARRATIVE The current proposal will provide structural and dynamic information on the transmembrane polypeptides of the human CB2 receptor. Knowledge of the specific orientations and precise distances between identified residues in contact with the ligand, as well as the conformation of the polypeptide-ligand complex, will be helpful in optimizing the binding properties and selection of ligands to the cannabinoid receptor. Therefore, the proposed work is expected to provide significant biomedical findings with therapeutic potential.",27849,ZRG1,Special Emphasis Panel,,1,194635,
7771859,R03,DA,1,,04/01/2010,03/31/2011,PAR-06-541,1R03DA027870-01,,NIDA:73850;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MILWAUKEE,UNITED STATES,PSYCHOLOGY,04,627906399,US,WI,532010340,UNIVERSITY OF WISCONSIN MILWAUKEE,"MUELLER, DEVIN ;",8842519;,1R03DA027870,04/01/2010,03/31/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AMPA Receptors; Addiction, Drug; Behavior; Cell Communication and Signaling; Cell Signaling; Cells; Chemical Dependence; Clinical; Cocaine; Common Rat Strains; Cues; Dependence, Drug; Development; Disease; Disorder; Drug Addiction; Drug Dependency; Drug Exposure; Drug Regulations; Drug Therapy; Drugs; Effectiveness; Electrodes; Extinction; Extinction (Psychology); Fear; Fright; Glutamates; Goals; Grant; Infusion; Infusion procedures; Intracellular Communication and Signaling; L-Glutamate; Lead; Learning; Mammals, Rats; Measures; Medial; Mediating; Medication; Memory; Methods; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; Nerve Cells; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neurons; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Play; Prefrontal Cortex; Prevention of relapse; Pyramidal neuron; Rat; Rattus; Receptors, AMPA; Receptors, N-Methylaspartate; Regulation; Regulations, Drug; Relative; Relative (related person); Research; Retrieval; Role; Self Administration; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Stimulus; Synapses; Synaptic; Synaptic Transmission; Training; Work; addiction; base; behavioral extinction; biological signal transduction; conditioned fear; disease/disorder; disorder later incidence prevention; drug addiction therapy; drug reward; drug seeking behavior; drug/agent; fear conditioning; heavy metal Pb; heavy metal lead; hippocampal pyramidal neuron; learning extinction; neural mechanism; neuromechanism; neuronal; patch clamp; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; public health relevance; reinforcer; response; social role",Glutamate and prefrontal regulation of cocaine seeking after extinction," Relevance  Perhaps more than any other field in learning and memory, extinction is directly applicable to the treatment of various clinical disorders, which arise when conditioned responses are pathologically over-expressed. This research will explore the glutamatergic mechanisms of consolidation of extinction learning as it pertains to drug seeking. Understanding the mechanisms by which the prefrontal cortex consolidates extinction of drug seeking could lead to the development of pharmacotherapies to increase the effectiveness of extinction-based therapies for treatment of addiction.",27870,ZDA1,Special Emphasis Panel,,1,73850,
7781127,R03,DA,1,,02/01/2010,01/31/2011,DA-09-021,1R03DA027942-01,,NIDA:37000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,UNIVERSITY PARK,UNITED STATES,MISCELLANEOUS,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"BROWN, LOUIS DAVIS;",9528017;,1R03DA027942,02/01/2010,01/31/2012,"12-20 years old; AOD use; Adolescence; Alcohol or Other Drugs use; Alcohols; Approaches to prevention; Behavior; Caring; Causality; Chemical Class, Alcohol; Communities; Cost Savings; Data Set; Data Sources; Dataset; Drug abuse; Drug usage; Drugs; Ensure; Etiology; Evaluation; Evidence based program; Factor Analyses; Factor Analysis; Funding; Lead; Measurement; Measures; Medication; Modeling; Models, Theoretic; Outcome; Outcome Measure; PROV; Pb element; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Preparedness; Prevention; Prevention Research; Prevention approach; Prevention program; Problem behavior; Process; Programs (PT); Programs [Publication Type]; Provider; Public Health; Questionnaires; Readiness; Reporter; Reporting; Research; Risk; Role; Saving, Cost; Schools; Sources, Data; Structure; Survey Instrument; Surveys; Theoretical model; Time; Tobacco; Training; Work; Youth; Youth 10-21; abuse of drugs; abuses drugs; addiction; adolescence (12-20); alcohol and other drug; anti social; antisocial; base; behavioral problem; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; drug/agent; evidence base; heavy metal Pb; heavy metal lead; improved; interest; member; prevent; preventing; programs; public health medicine (field); public health relevance; social role; substance use; substance use prevention; teenage",Using Coalitions to Support Evidence-Based Programs and Prevent Drug Abuse, Project Narrative/Relevance: This study will enhance understanding of how community coalitions can support the dissemination and implementation of evidence-based programs that are known to prevent early drug use and abuse. Findings can improve prevention practice and reduce drug abuse and addiction rates at a population level.,27942,ZRG1,Special Emphasis Panel,,1,37000,
7772087,R03,DA,1,,02/01/2010,01/31/2011,PAS-07-327,1R03DA027965-01,,NIDA:194635;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,MISCELLANEOUS,08,001423631,US,MA,02115,NORTHEASTERN UNIVERSITY,"BOWMAN, ANNA LOUISE;",9783784;,1R03DA027965,02/01/2010,01/31/2012,"2-arachidonoyl-glycerol; 2-arachidonoylglycerol; 2-arachidonyl-glycerol; 2-arachidonylglycerol; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-; Accounting; Advocate; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acids; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Brain; Cannabinoids; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Signaling; Chemicals; Combining Site; Computer Simulation; Computerized Models; Cost Savings; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Docking; Drug abuse; Elements; Encephalon; Encephalons; Endocannabinoids; Ensure; Enzymes; Equilibrium; FAAH protein; Flooding; Floods; Glycerol Monoester Hydrolases; Glycerol-ester acylhydrolase; Homology Modeling; Hot Spot; Hot Spots (Area of Increased Mortality); Human; Human, General; Hydrolysis; INFLM; Idiopathic Parkinson Disease; Inflammation; Intracellular Communication and Signaling; Lewy Body Parkinson Disease; Ligands; Lipids; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Medical; Metabolic syndrome; Methods; Mining; Minings; Modeling; Models, Computer; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; Monoacylglycerol Lipases; Monoglyceride Esterases; Monoglyceride Hydrolase; Monoglyceride Lipases; Nerve Degeneration; Nervous System, Brain; Neuron Degeneration; Obesity; Organism-Level Process; Organismal Process; Pain; Painful; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Physiologic Processes; Physiological Processes; Primary Parkinsonism; Primary Senile Degenerative Dementia; Production; Proteins; Reactive Site; Receptor Protein; Research; Saving, Cost; Screening procedure; Serine Hydrolase; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Solvents; Structure; System; System, LOINC Axis 4; Testing; Therapeutic; Time; Tissues; Validation; Work; abuse of drugs; abuses drugs; activity-based protein profiling; adiposity; aminoacid; balance; balance function; base; biological signal transduction; cannabinoid receptor; clinical data repository; clinical data warehouse; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; corpulence; corpulency; corpulentia; cost; data repository; dementia of the Alzheimer type; disease/disorder; drug discovery; fatty acid amide hydrolase; flexibility; gene product; in silico; inhibitor; inhibitor/antagonist; insight; molecular dynamics; neural degeneration; neurodegeneration; neuronal degeneration; novel; obese; obese people; obese person; obese population; oleamide hydrolase; pharmacophore; primary degenerative dementia; public health relevance; receptor; relational database; screening; screenings; senile dementia of the Alzheimer type; small molecule; tool; virtual; virtual simulation","VIRTUAL SCREENING TO IDENTIFY NOVEL, SELECTIVE MONOACYLGLYCEROL LIPASE INHIBITORS"," OTHER PROJECT INFORMATION - SECTION 7 - PROJECT NARRATIVE 2-arachidonoylglycerol (2-AG) is a signaling lipid which is degraded by monoacylglycerol lipase (MGL). Compounds which inhibit MGL, and thereby increase the level of 2-AG, are considered therapeutic towards pain, inflammation, and neurodegenerative/neuroinflammatory disorders including Alzheimer's and Parkinson's disease. This proposal aims to develop a fast, computational approach to search large databases of compounds in order to identify novel, potent and selective MGL inhibitors.",27965,ZRG1,Special Emphasis Panel,,1,194635,
7779263,R03,DC,1,,01/15/2010,12/31/2010,PAR-07-287,1R03DC010465-01,,NIDCD:144620;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,MADISON,UNITED STATES,PSYCHOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KAUSHANSKAYA, MARGARITA ;",9782561;,1R03DC010465,01/15/2010,12/31/2012,"0-11 years old; Academic achievement; Accounting; Age; Bypass; Child; Child Youth; Children (0-21); Detection; Development; Diagnostic; Early Diagnosis; Early identification; English Language; FLR; Failure (biologic function); Goals; Health; History; Human, Child; Impairment; Individual; Knowledge; Language; Language Development; Language Disorders; Language disability; Laws; Learning; Linguistic; Linguistics; Link; Logic; Measures; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods; Modeling; Pattern; Performance; Population; Procedures; Process; Public Health; QOL; Quality of life; Recording of previous events; Research; Risk; Short-Term Memory; Sound; Sound - physical agent; Speech; Stimulus; Structure; Students; Testing; United States; Vocabulary; Vocabulary Words; Work; acquiring language skills; base; children; early detection; experience; experiment; experimental research; experimental study; failure; improved; indexing; language acquisition; language deficit; language learning; lexical; long term memory; meetings; novel; peer; phonological; phonology; public health medicine (field); public health relevance; research study; skills; sound; success; successful intervention; tool; working memory; youngster",Word Learning and Word Knowledge in Monolingual and Sequential Bilingual Children," Project Narrative The current project aims to improve diagnostic practices with children who speak English as a second language, and who therefore cannot be tested using tools developed for monolingual English-speaking children. In the proposed work, we test whether word-learning tasks can serve as markers of typical vocabulary development in Spanish-speaking bilingual children who are acquiring English as a second language. Because early diagnosis of a language difficulty is key to successful intervention and to the child's ultimate quality of life, identification of tasks that can accurately index bilingual children's typical vs. atypical development can make significant contribution to public health.",10465,ZDC1,Special Emphasis Panel,,1,144620,
7789382,R03,EB,1,,02/01/2010,01/31/2011,PA-06-180,1R03EB008790-01A2,,NIBIB:72409;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,RALEIGH,UNITED STATES,ENGINEERING (ALL TYPES),04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"LOBOA, ELIZABETH GRACE;",8008816;,1R03EB008790,02/01/2010,01/31/2012,"Adipose tissue; Adverse reactions; Alkaline Phosphatase; Area; Attention; Au element; Autograft; Autologous Transplantation; Autotransplant; Biochemical; Blood Coagulation Factor IV; Body Tissues; Bone; Bone Formation; Bone Tissue; Bone Transplantation; Bone and Bones; Bones and Bone Tissue; Ca++ element; Calcium; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chondrogenesis; Cilia; Coagulation Factor IV; Collagen; Culture Media; Data; Defect; Deposit; Deposition; Electrodeposition; Electroplating; Environment; Exhibits; FLR; Factor IV; Failure (biologic function); Fats; Fatty Tissue; Fatty acid glycerol esters; Future; Gel; Genes; Genetic; Gold; Graft Material; Grafting, Bone; Hair; Harvest; Human; Human, General; Infection; Lamellar Bone; Lead; Load-Bearing; Loadbearing; Man (Taxonomy); Man, Modern; Mature Bone; Mechanics; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Metal Plating; Methacrylates; Minerals; Mother Cells; Operation; Operative Procedures; Operative Surgical Procedures; Organelles; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Osteogenesis; Pain; Painful; Patients; Pb element; Physical Stimulation; Play; Population; Procedures; Progenitor Cells; Property; Property, LOINC Axis 2; Public Health; RNA, Small Interfering; Relative; Relative (related person); Replacement Therapy; Role; Site; Small Interfering RNA; Source; Stem cells; Stimulus; Structure; Surgical; Surgical Interventions; Surgical Procedure; Testing; Tissue Engineering; Tissues; Transplantation, Autologous; Transplanted tissue; Weight-Bearing; Weight-Bearing state; Weightbearing; Work; adipogenesis; adipose; alkaline phosphomonoesterase; appendage; base; bone; bone cell; cultured cell line; engineered tissue; failure; glycerophosphatase; growth media; heavy metal Pb; heavy metal lead; human stem cells; in vivo; irritation; lipid biosynthesis; lipogenesis; myogenesis; osteogenic; public health medicine (field); public health relevance; reconstruction; response; sensor; siRNA; social role; stem cell fate; surgery; white adipose tissue; wound; yellow adipose tissue",Tensile Strain-Induced Osteogenesis of Human Mesenchymal Stem Cells in 3D Culture," PROJECT NARRATIVE Relevance to Public Health: the gold standard for bone grafts (90% of surgeries) is the autograft where bone is removed from one portion of the patient's body and grafted to a wound elsewhere. While minimizing tissue rejection, limitations of this procedure include limited supply of bone in the body, infection, and pain at the donor site. Large bone defects can be reconstructed with materials such as metal plates or methyl methacrylate. However, these are foreign materials and may cause a variety of adverse reactions, including irritation, encapsulation of the replacement material, and eventual exposure of the reconstructed area. If this happens, the foreign material has to be removed and the site reconstructed with bone. Bone truly is the best material for reconstruction of bone defects. Being able to create a tissue- engineered bone construct using a patient's own stem cells would eliminate the need for painful bone grafts and/or use of foreign materials to fill critical-sized bone defects.",8790,MTE,Musculoskeletal Tissue Engineering Study Section,A2,1,72409,
7777140,R03,ES,1,,01/11/2010,12/31/2010,PA-06-180,1R03ES017860-01,,NIEHS:75250;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BURLINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"FUKAGAWA, NAOMI K;",1948536;,1R03ES017860,01/11/2010,12/31/2011,"Agriculture; Air Pollution; Animals; Apoptosis; Apoptosis Pathway; Area; Aromatic Compounds; Aspiration, Respiratory; Atmosphere; Atmosphere, planetary; Attenuated; Belief; Biological; Breathing; COT Gene; Caliber; Cancer Osaka Thyroid Gene; Cancer Osaka Thyroid Oncogene; Cancer of Lung; Cancers; Carbon Monoxide; Cardiac Diseases; Cardiac Disorders; Cardiopulmonary; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Death; Cell Death, Programmed; Cells; Cellular Expansion; Cellular Growth; Cellular Oncogene; Characteristics; Chemistry; Common Rat Strains; Cor pulmonale; Crude Oil; Cytokines, Chemotactic; Data; Development; Diameter; Diesel Fuels; Disease; Disorder; Distal; EC 2.7.2-; ESTF; Ecological impact; Endotoxins; Energy-Generating Resources; Engineering; Engineerings; Environment; Environmental Factor; Environmental Impact; Environmental Risk Factor; Epidemiology; Epithelial Cells; Equilibrium; Europe; Exposure to; Extracellular Signal-Regulated Kinases; Family; Fats; Fatty acid glycerol esters; Fibrosis; Fuels, Diesel; Future; GeneHomolog; Head and Neck, Thyroid; Health; Heart; Heart Diseases; Hematopoietic; Homolog; Homologous Chemotactic Cytokines; Homologous Gene; Homologue; Human; Human Cell Line; Human, General; Hydrocarbons; Immunoglobulin Enhancer-Binding Protein; Impact, Environmental; In Vitro; Inflammation Mediators; Inflammatory Response; Inhalation; Inhaling; Inspiration, Respiratory; Intercrines; Intervention; Intervention Strategies; Lead; Letters; Link; Lung; Lung Parenchyma; Lung Tissue; Lung diseases; MAP Kinase Kinase Kinase; MAP kinase; MAP3 Kinases; MAP3K8; MAP3K8 gene; MAPK; MAPKKKs; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mice; Mitogen Activated Protein Kinase 8 Gene; Mitogen-Activated Protein Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nasal; Nose; Nose, Nasal Passages; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Organ System, Cardiovascular; Particle Size; Particulate; Particulate Matter; Pathogenesis; Pathway interactions; Pb element; Petroleum; Play; Pneumonia; Pneumonitis; Process; Production; Property; Property, LOINC Axis 2; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proto-Oncogene Serine/Threoine Protein Kinase Gene; Proto-Oncogenes; Public Health; Pulmonary Body System; Pulmonary Cancer; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Heart Disease; Pulmonary Heart Disorder; Pulmonary Inflammation; Pulmonary Organ System; Pulmonary malignant Neoplasm; Rat; Rattus; Regulation; Reporting; Research; Respiratory Disease; Respiratory Disorder; Respiratory System; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory System, Nose, Nasal Passages; Respiratory system (all sites); Role; S element; SIS cytokines; Schools; Science of Chemistry; Scientist; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Source; Structure of parenchyma of lung; Sulfur; T-Cell Activation; TPL-2; Testing; Threonine Kinase; Thyroid; Thyroid Gland; Transcription Factor NF-kB; Transportation; Tumor Progression Locus-2; Ultrafine; Universities; Vascular, Heart; Vegetable Oils; Vermont; agricultural; balance; balance function; base; c-COT; c-ONC; cardiopulmonary disease; cardiopulmonary disorder; cardiovascular disorder; cell growth; chemoattractant cytokine; chemokine; circulatory system; cytokine; design; designing; disease/disorder; energy source; environmental risk; exhaust; heart disorder; heavy metal Pb; heavy metal lead; in vivo; inspiration; interventional strategy; kappa B Enhancer Binding Protein; lung cancer; lung disorder; lung injury; macrophage; malignancy; necrocytosis; neoplasm/cancer; nuclear factor kappa beta; particle; pathway; petroleum oil; planetary Atmosphere; protooncogene; public health medicine (field); public health relevance; pulmonary; respiratory tract; response; social role",Tlp2/COT Regulation of ERK1/2 and NF-kB in Response to Particulates," Project Narrative Biodiesel has been touted as an important strategy for energy independence as well as sustainability in terms of agricultural production and reduced environmental impact from the transportation sector, but as with petrodiesel, combustion of biodiesel produces particulate air pollution. Adverse health effects have been reported at unexpectedly low concentrations of particulate matter in air pollution, leading scientists and public health officials to conclude that long-term exposure to combustion-related particulate air pollution is a significant environmental risk factor for heart and lung diseases. Despite the belief that biofuels may be better for the environment and for human health, there is very limited information about the biological and health effects of biodiesel emissions so this project will compare and contrast the biological effects of emission particles from the combustion of petro- and biodiesel in an effort to lay the groundwork for future studies aimed at elucidating the mechanisms responsible for the significant relationship between airborne particulates and lung and heart disease and at developing approaches to reduce the adverse health consequences of air pollution.",17860,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,1,75250,
7788621,R03,HD,1,,01/15/2010,12/31/2010,PA-06-402,1R03HD057984-01A2,,NICHD:75000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,COLLEGE PARK,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"HOWARD, DONNA ELISE;",7598046;,1R03HD057984,01/15/2010,12/31/2011,"0-11 years old; 12-20 years old; 21+ years old; Adolescence; Adolescent; Adolescent Development; Adolescent Youth; Adult; Area; Attitude; Baltimore; Behavior; Belief; Child; Child Youth; Children (0-21); Code; Coding System; Complex; Computer Programs; Computer software; Development; Enrollment; Environment; Extended Family; Family; Family, Extended; Female Adolescents; Focus Groups; Foundations; Future; Goals; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; Human, Adult; Human, Child; Incidence; Institution; Interview; Investigators; Lead; Maintenance; Maintenances; Maryland; Measures; Method LOINC Axis 6; Methodology; Methods; Modeling; Nature; Parents; Participant; Partner in relationship; Pattern; Pb element; Process; Religion and Spirituality; Research; Research Personnel; Researchers; Retrieval; Risk; Role; Sampling; Schools; Series; Sex Behavior; Sexual Activity; Sexual Behavior; Sexual Health; Sexuality; Shapes; Siblings; Social Controls; Social support; Socialization; Socializations; Software; Study models; T-Lymphotropic Virus Type III Infections, Human; Victimization; abusive relationship; adolescence (12-20); adolescent girl; adult human (21+); base; children; computer program/software; data management; dating behavior; dating violence; enroll; girls; heavy metal Pb; heavy metal lead; high school; information gathering; intimacy; intimate behavior; juvenile; juvenile human; mate; novel; partner violence; peer; prevent; preventing; problem, partner, abuse, violent; public health relevance; relationship abuse; religious; sex activity; social role; social support network; teenage; unintended pregnancy; violent partner; youngster",Girls Healthy Dating Relationship Study," Project Narrative The aim of this study is to better understand how adolescent girls' ideas about healthy and harmful dating relationships may be shaped by religious affiliation, beliefs and practices and whether these factors may be related to their risk of being a victim of dating violence. Information gathered from this study can contribute greatly to our understanding of the ways religious socialization may influence adolescent development and sexual health.",57984,CHHD,National Institute of Child Health and Human Development Initial Review Group,A2,1,75000,
7789375,R03,HD,1,,01/15/2010,12/31/2010,PA-06-180,1R03HD060758-01A1,,NICHD:71808;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,TALLAHASSEE,UNITED STATES,NONE,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"WANZEK, JEANNE ;",9507784;,1R03HD060758,01/15/2010,12/31/2011,Accounting; Achievement; Achievement Attainment; Active Follow-up; Attention; Code; Coding System; Collaborations; Comprehension; Data; Development; Florida; Frequencies (time pattern); Frequency; Health Status; Individual; Instruction; Learning Disabilities; Learning disability; Level of Health; Linear Models; Link; Measures; Outcome; Performance; Printing; Problem behavior; Public Health; QOL; Quality of life; Reading; Risk; Sampling; Schools; Series; Structure; Students; TXT; Text; Time; Videotape; behavioral problem; cohort; follow-up; kindergarten; literacy; prevent; preventing; prognostic; public health medicine (field); public health relevance; skills; teacher,Frequency and Quality of Academic Engagement with Teachers and Text and the Relat," Project Narrative Poor academic performance is of great concern in that it is prognostic of overall low quality of life. Numerous studies have documented the relationship between literacy levels and health outcomes (Berkman et al., 2004). As a result, ways in which low reading achievement can be prevented or ameliorated are highly relevant to the public health sector.",60758,CHHD,National Institute of Child Health and Human Development Initial Review Group,A1,1,71808,
7760210,R03,HD,1,,02/01/2010,01/31/2011,PA-06-180,1R03HD062471-01,,NICHD:70566;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,ITHACA,UNITED STATES,OTHER BASIC SCIENCES,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"SUAREZ, SUSAN STEVENS;",1896736;,1R03HD062471,02/01/2010,01/31/2012,"Behavior; Biological; Cannot achieve a pregnancy; CatSper; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cells; Cellular Migration; Chemoattractants; Chemotactic Factors; Chemotaxins; Chemotaxis; Contraception; Contraceptive Usage; Contraceptive methods; Corpus Luteum Hormone; Couples; Cytoplasmic Membrane; Delta4-pregnene-3,20-dione; Diaphanoscopy; Difficulty conceiving; Epithelium; Exposure to; FLR; Failure (biologic function); Fallopian Tubes; Fertility Control; Fertility/Fertilization; Fertilization; Flagella; Head of the Spermatozoon; Image; In Vitro; Infertility; Inhibition of Fertilization; Intracellular Communication and Signaling; Mammalian Oviducts; Mammals, Mice; Mice; Mice, Mutant Strains; Motility; Motility, Cellular; Movement; Murine; Mus; Mutant Strains Mice; Nuclear Envelope; Nuclear Membrane; Oocytes; Ovocytes; Partner in relationship; Pattern; Pilot Projects; Plasma Membrane; Pregn-4-ene-3,20-dione; Pregnenedione; Process; Progesterone; Proteomics; Reporting; Research; Salpinx; Side; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solid; Source; Sperm; Sperm Head; Sperm Motility; Spermatozoa; Testing; Therapeutic Progesterone; Time; Transillumination; Uterine Tubes; Work; base; biological signal transduction; body movement; cell motility; complement chemotactic factor; contraceptive use; egg; experiment; experimental research; experimental study; failure; imaging; in vivo; infertile; male; mate; mouse model; mouse mutant; oviduct; ovulation time; pilot study; plasmalemma; pregnant; public health relevance; research study; response; sperm cell; sperm mobility; sperm specific ion channel; unable to bear children; zoosperm",Sperm Motility Modulations Crucial to Fertilization," Narrative Approximately 7% US couples reported that they did not get pregnant after a year without contraceptive use. Roughly half of the cases of infertility are attributed to a male factor, particularly low sperm quantity and/or motility. To fertilize, sperm must be able to hyperactivate and also to respond to chemotactic factors to direct their movement toward the egg. Nothing is known about the relationship of hyperactivation to chemotaxis. The objective is to elucidate this relationship, by analyzing behavior of sperm in the oviduct and using cell biological and proteomic approaches to determine how sperm movement is modulated to enable them to reach the egg.",62471,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,70566,
7770429,R03,HD,1,,01/15/2010,12/31/2010,PA-06-180,1R03HD062600-01,,NICHD:73662;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BOULDER,UNITED STATES,PSYCHOLOGY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"BANICH, MARIE ;",6795014;,1R03HD062600,01/15/2010,12/31/2011,"12-20 years old; 21+ years old; Address; Adolescence; Adult; Affect; Age; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anatomic; Anatomical Sciences; Anatomy; Anti-Human Globulin Consumption Test; Antiglobulin Consumption Test; Antiglobulin Test; Antihuman Globulin Consumption Test; Anxiety; Attention; Basic Research; Basic Science; Behavioral; Brain; Brain region; Brain scan; Child Abuse; Childhood; Childhood Abuse; Clinical; Cognitive; Cognitive deficits; Collaborations; Coomb's; Coombs' Test; Corpus Callosum; Corpus Callosums; Country; Data; Department of Health and Human Services; Department of Health and Human Services (U.S.); Depression; Development; Diagnosis; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Distress; Early treatment; Emotional; Emotional disorder; Encephalon; Encephalons; Face; Functional Magnetic Resonance Imaging; Goals; HHS; History; Hour; Human, Adult; Individual; Intervention; Intervention Strategies; Investigation; Journals; Knowledge; Laboratories; Link; MRI, Functional; Magazine; Magnetic Resonance Imaging, Functional; Medical Specialities; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; NICHD; National Academy of Sciences; National Academy of Sciences (U.S.); National Institute of Child Health and Human Development; Nature; Nervous; Nervous System, Brain; Neural Development; Neurophysiology - biologic function; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Outcome; PTSD; Participant; Pattern; Pear; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Psychologist; Psychopathology; Publishing; Recording of previous events; Regulation; Relative; Relative (related person); Reporting; Research; Resolution; Scanning; Science; Science of Anatomy; Sensitivity Training Groups; Severities; Sexual abuse; Short-Term Memory; Social Support System; Specialties, Medical; Specialty; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Support System; Symptoms; System; System, LOINC Axis 4; T-Groups; Therapeutic Intervention; Thinking; Thinking, function; Time; Trauma; United States Department of Health and Human Services; United States Dept. of Health and Human Services; United States National Academy of Sciences; Work; abnormal psychology; adolescence (12-20); adolescent trauma; adult human (21+); adult youth; amygdaloid nuclear complex; anatomy; base; childhood trauma; cognitive control; cognitive function; design; designing; diffusion tensor imaging; emerging adult; experience; fMRI; facial; falls; graduate student; intervention therapy; interventional strategy; medical specialties; meetings; neural; neural control; neural function; neural mechanism; neural regulation; neurodevelopment; neuromechanism; neuroregulation; pediatric; pediatric trauma; physical abuse; physical maltreatment; public health relevance; relating to nervous system; sex abuse; teenage; traumatic neurosis; working memory; young adult",Cognitive and Brain Processes in Individuals with Childhood Interpersonal Trauma," The current project aims to understand how trauma experienced during childhood affects the thinking styles and pattern of brain activity of people in adulthood. In particular, the project examines the hypothesis that childhood trauma affects the ability to pay attention, especially in the face of distracting information, and the ability to control information in one's memory, such as is required to suppress particular thoughts. These changes are proposed to be accompanied by changes in the brain systems that support these abilities. Understanding the effects of trauma on thoughts and the brain should enable the design and implementation of better interventions to reduce the negative effects of trauma experienced during childhood.",62600,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,73662,
7766031,R03,HG,1,,01/26/2010,12/31/2010,PA-08-013,1R03HG005225-01,,NHGRI:37000;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,MEMPHIS,UNITED STATES,MISCELLANEOUS,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"STRONG, CARSON MCCARTY;",9677409;,1R03HG005225,01/26/2010,12/31/2011,"0-11 years old; 21+ years old; Accounting; Address; Adult; Attention; Awareness; Awarenesses; Benefits and Risks; Child; Child Youth; Children (0-21); Department of Health and Human Services; Department of Health and Human Services (U.S.); Diagnosis; Equilibrium; Ethical Analyses; Ethical Analysis; Ethical Issues; Ethics; Fathers; Fetal Experimentation; Fetal Research; Fetus; Future; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Condition; Genetic Diseases; Genetic Intervention; Goals; HHS; Health; Hereditary Disease; Human; Human, Adult; Human, Child; Human, General; Informed Consent; Intervention, Genetic; Issues, Ethical; Journal Article; Journal Article (PT); Journal Article [Publication Type]; Knowledge; Life; Literature; Man (Taxonomy); Man, Modern; Methods; Molecular Biology, Gene Therapy; Molecular Disease; Mothers; Nature; Organizations, Professional; Peer Review; Pregnant Women; Professional Organizations; Publications; Publishing; Regulation; Reporting; Research; Research Design; Research Subjects; Resolution; Risk; Scientific Publication; Societies; Specific qualifier value; Specified; Study Type; Termination of pregnancy; Therapeutic Studies; Therapy Research; Therapy, DNA; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Woman; adult human (21+); balance; balance function; base; children; design; designing; fetal; gene therapy; genetic disorder; genetic therapy; hereditary disorder; human subject; human subject protection; improved; journal article; minimal risk; neonate; prenatal; public health relevance; study design; transfer of a gene; unborn; youngster",Human Subjects Protections in Prenatal Gene Transfer Research," Project Narrative RELEVANCE: Gene therapy research seeks treatments for serious genetic diseases, and it promises to have a significant health impact for society. In the future, it is anticipated that research into human prenatal gene therapy will be feasible and important. This project seeks to improve the protections that will be provided to subjects of prenatal gene therapy research, thereby contributing to the ethical standards for such research.",5225,ELS,"Ethical, Legal, and Social Implications of Human Genetics Study Section",,1,37000,
7859772,R03,HS,1,,02/01/2010,01/31/2011,PAR-06-448,1R03HS018697-01,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,BETHESDA,UNITED STATES,,08,612993097,US,MD,20814,MEDICAL TECHNOLOGY AND PRACTICE PATTERNS,"ZHANG, YI ;",10020190;,1R03HS018697,02/01/2010,01/31/2012,,The Effect of Dialysis Chains on Mortality in Patients Receiving Hemodialysis," The Effect of Dialysis Chains on Mortality in Patients Receiving Hemodialysis According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the death rate of 24% annually among the end-stage renal disease (ESRD) population in the U.S. remains ""unacceptably high."" With the steady increase in the incidence and prevalence of patients with ESRD, it is becoming an even more urgent public health problem both medically and economically. The vast majority of ESRD patients (more than 90%) receive hemodialysis 3 times per week from the nation's roughly 4,000 Medicare-certified dialysis facilities. Substantial differences in patient mortality rate might be influenced by dialysis facility characteristics in addition to patient case mix factors. Facility-specific policies governing dialysis care and associated practice patterns, as opposed to patient-specific causes, have been under-researched and might play an important role in influencing patient outcomes. In this project, the proliferation of chains providing efficient dialysis services will be examined with regard to their influence on patient outcomes and mortality. The potential findings of the proposed study will shed new light on the relationship between type of facility and patient mortality, aid clinicians and policy makers in identifying optimal management practices, and eventually improve care and outcomes of ESRD patients.",18697,HSR,Health Systems Research,,1,51026,
7844780,R03,MH,1,,02/01/2010,11/30/2010,PAR-09-129,1R03MH089489-01,,OD:47625;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"WAHL, GEOFFREY MYLES;",1895553;,1R03MH089489,02/01/2010,11/30/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Amino Acid Sequence; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogene Protein p53; Antiproliferative Agents; Antiproliferative Drugs; Behavior; Binding; Binding (Molecular Function); C-terminal; Cancer Drug; Cancer Treatment; Cancers; Cardiovascular Diseases; Cause of Death; Cells; Cellular Tumor Antigen P53; Cessation of life; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Complex; Data; Death; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; E3 Ligase; E3 Ubiquitin Ligase; Exhibits; Expression Profiling; Expression Signature; Follow-Up Studies; Followup Studies; Future; Generalized Growth; Genes, p53; Genetic; Growth; HMG-20; High Mobility Protein 20; High Throughput Assay; Homologous Protein; Human; Human, General; In Vitro; Kinetic; Kinetics; Lead; Macropain; Macroxyproteinase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Medication; Modification; Molecular Bank; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Multicatalytic Proteinase; N-terminal; NH2-terminal; NIH; National Institutes of Health; National Institutes of Health (U.S.); Oncoprotein p53; P53; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein P53; Phosphoprotein pp53; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Homolog; Protein Structure, Primary; Protein TP53; Protein p53; ProteinHomolog; Proteins; Proteosome; Research; Sampling; Screening procedure; Specificity; TP53; TP53 gene; TRP53; Therapeutic; Tissue Growth; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumor-Specific Treatment Agents; Ubiquitin; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligase E3; United States; United States National Institutes of Health; anticancer agent; anticancer drug; anticancer therapy; base; cancer therapy; cardiovascular disorder; chemotherapy; disease/disorder; drug development; drug discovery; drug/agent; gene product; heavy metal Pb; heavy metal lead; high throughput screening; inhibitor; inhibitor/antagonist; malignancy; molecuar profile; molecular signature; multicatalytic endopeptidase complex; neoplasm/cancer; neoplastic cell; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; p53 Antigen; p53 Tumor Suppressor; pathway; protein sequence; public health relevance; repository; screening; screenings; small molecule; small molecule libraries; tumor; ubiquitin ligase; ubiquitin-protein ligase",High throughput screen for inhibitors of the mdm2/mdmx interaction," Project Narrative Cancer ranks second to cardiovascular diseases in causes of death in the United States, and is a leading killer worldwide. The p53 tumor suppressor is wild type but functionally inactivated in ~50% of all cancers, and is an attractive target for reactivation by small molecule anticancer drugs. The Aims of this proposal describe an approach to identify a novel class of p53 activating compounds, and their successful completion will have implications for future treatment of cancers harboring wild type p53.",89489,ZRG1,Special Emphasis Panel,,1,47625,
7844464,R03,MH,1,,01/15/2010,11/30/2010,PAR-09-129,1R03MH089536-01,,OD:37250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOUISVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"JONSSON, COLLEEN B;",1875928;,1R03MH089536,01/15/2010,11/30/2011,"Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Aves; Avian; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Birds; Body Tissues; Cells; Cessation of life; Chemistry; Death; Development; Double-Stranded RNA; Epidemic; Flu virus; Gene Products, RNA; Grippe; HOSP; High Throughput Assay; Hospitalization; Influenza; Influenza A virus; Influenza Virus; Influenza Viruses Type A; Life Cycle; Life Cycle Stages; Lower respiratory tract structure; Mexico; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; North America; Orthomyxovirus Type A; Penetration; Proteins; Public Health; RNA; RNA Binding; RNA Viruses; RNA, Double-Stranded; RNA, Non-Polyadenylated; Research; Ribonucleic Acid; Science of Chemistry; Screening procedure; Specificity; Tissues; United States; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus Diseases; Viruses, General; base; drug discovery; dsRNA; flu infection; gene product; high throughput screening; influenza infection; influenzavirus; influenzavirus (unspecified); inhibitor; inhibitor/antagonist; life course; lower respiratory tract; pandemic; pandemic disease; public health medicine (field); public health relevance; screening; screenings; small molecule; swine flu; tool; viral infection; virus infection; virus protein",Discovery of Small Molecule Probes for Influenza NS1A," Influenza viruses are negative-sense, single-stranded RNA viruses that infect the upper and lower respiratory tracts and cause substantial morbidity and mortality annually. In the United States, approximately 36,000 deaths are attributed to influenza or its complications each year. Influenza A viruses, which also infect a wide number of avian and mammalian species, pose a considerable public health burden with epidemic and pandemic potential. The proposed research effort seeks to identify small molecule inhibitors for the RNA binding activity of NS1A, a key viral protein in the life cycle of the virus. ",89536,ZRG1,Special Emphasis Panel,,1,37250,
7762959,R03,TW,1,,01/01/2010,11/30/2010,PAR-08-222,1R03TW008228-01A1,,FIC:59795;,2010,FOGARTY INTERNATIONAL CENTER,,MINNEAPOLIS,UNITED STATES,DENTISTRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"SIMONE, DONALD A;",1889016;,1R03TW008228,01/01/2010,11/30/2012,"0-11 years old; 21+ years old; Absence of pain sensation; Absence of sensibility to pain; Accounting; Adenosine; Adult; Adverse effects; Afferent Neurons; Agonist; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Behavioral; Bone; Bone and Bones; Bone remodeling; Bones and Bone Tissue; Calcium Ion Signaling; Calcium Signaling; Cancer Model; Cancer Pain Management; Cancer of Bone; CancerModel; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Central Nervous System; Child; Child Youth; Children (0-21); Co-culture; Cocultivation; Coculture; Coculture Techniques; Collaborations; Contin, MS; Development; Diagnosis; Dorsal Root Ganglia; Dose; Effectiveness; Electrophysiology; Electrophysiology (science); Feels no pain; Fiber; Ganglia, Spinal; Grant; Human, Adult; Human, Child; Hyperalgesia; Hyperalgesic Sensations; INFLM; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Infumorph; Institutes; Intracellular Communication and Signaling; Kadian; Lead; Ligands; MSir; Malignant Bone Neoplasm; Malignant Cell; Malignant Neoplasms; Malignant Osseous Neoplasm; Malignant Osseous Tumor; Malignant Tumor; Malignant Tumor of the Bone; Mammals, Mice; Mechanics; Medulla Spinalis; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Modeling; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Murine; Mus; NCI; NCI Organization; NIH; National Cancer Institute; National Institutes of Health; National Institutes of Health (U.S.); Neoplasm Metastasis; Nerve Cells; Nerve Degeneration; Nerve Endings; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuron Degeneration; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropathy; Neurophysiology / Electrophysiology; No sensitivity to pain; Nociception; Nociceptors; Opioid; Opioid Receptor; Oramorph; Oramorph SR; Osseous Cancer; P2X; P2X-receptor; Pain; Pain Control; Pain Therapy; Pain management; Painful; Patients; Pb element; Peripheral; Physiology; Public Health; QOL; Quality of life; Receptor Protein; Receptors, Opiate; Relative; Relative (related person); Reporting; Research; Resistance; Roxanol; Secondary Neoplasm; Secondary Tumor; Sensory; Sensory Cell Afferent Neuron; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Spinal Ganglia; Statex SR; TRPV1; TRPV1 gene; Therapeutic; Therapeutic Uses; Treatment Side Effects; Tumor Cell Migration; Ukraine; United States; United States National Institutes of Health; WHO; World Health Organization; adult human (21+); analgesia; biological signal transduction; bone; bone remodelling; cancer cell; cancer metastasis; cancer pain; children; chronic pain; chronic painful condition; dorsal root ganglion; experience; fibrosarcoma; heavy metal Pb; heavy metal lead; hyperalgia; improved; in vitro Model; in vivo; injured; malignancy; neoplasm/cancer; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; neuronal excitability; neuropathic; new approaches; nociceptive; novel; novel approaches; novel strategies; novel strategy; patch clamp; public health medicine (field); public health relevance; receptor; receptor function; release factor; resistant; response; side effect; therapy adverse effect; treatment adverse effect; triphosphate; tripolyphosphate; tumor; tumor growth; youngster",Functional Interactions between Cancer Cells and Sensory Neurons," Narrative  It is estimated by the National Cancer Institute that more than 1.4 million new cases of cancer were diagnosed in the United States in 2007, and the World Health Organization estimates that up to 15 million new cases of cancer may be diagnosed world-wide in 2020. Approximately 85% of adult patients with terminal cancer report intolerable pain and up to 75% of children with cancer experience pain. Understanding the mechanisms that drive cancer pain so that new and improved therapeutic approaches for pain management can be developed is a relevant public health issue.",8228,ICP1,International and Cooperative Projects - 1 Study Section,A1,1,59795,
7749904,R13,AI,1,,01/04/2010,12/31/2010,PA-08-149,1R13AI084376-01,,NIAID:8000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI084376,01/04/2010,12/31/2010,"APF-1; ATP-Dependent Proteolysis Factor 1; Basic Research; Basic Science; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Cell surface; Clinical Trials; Clinical Trials, Unspecified; Diabetes Mellitus; Disease; Disorder; Drug Industry; Dysfunction; EC 2.7; Enzymes; Fostering; Functional disorder; Future; Generalized Growth; Genetic analyses; Growth; HMG-20; High Mobility Protein 20; INFLM; Immune; Immunoglobulin Enhancer-Binding Protein; Industry, Pharmaceutic; Inflammation; Inflammatory; Intracellular Communication and Signaling; Kinases; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mice; Molecular; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; New Mexico; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Osteoporosis; Pharmaceutical Industry; Phosphotransferases; Physiopathology; Receptor Protein; Regulation; Research; Role; Scientist; Signal Transduction; Signal Transduction Systems; Signaling; TLR protein; Therapeutic Intervention; Tissue Growth; Toll-like receptors; Transcription Factor NF-kB; Transducers; Transphosphorylases; Ubiquitin; Whole Organism; Work; biological signal transduction; cardiovascular disorder; clinical investigation; conference; diabetes; disease/disorder; genetic analysis; inhibitor; inhibitor/antagonist; interest; intervention therapy; kappa B Enhancer Binding Protein; malignancy; meetings; neoplasm/cancer; nuclear factor kappa beta; ontogeny; pathophysiology; receptor; social role; symposium; transcription factor",NF-kappaB in Inflammation and Disease," PROJECT NARRATIVE The continuing growth in the field of NF- B research has been accelerated by discoveries that reveal the ever- increasing importance of NF- B in several diseases including cancer, diabetes, osteoporosis, cardiovascular diseases, and in immune and inflammatory disorders. As a result of these discoveries, NF- B has become of great interest to the pharmaceutical industry and remains a prime target for therapeutic intervention in many diseases. The NF-kappaB in Inflammation and Disease meeting will be organized to foster interaction between basic scientists and clinicians alike to view the importance of NF- B from the perspective of the whole organism.",84376,ZAI1,Special Emphasis Panel,,1,8000,
7796947,R13,AI,1,,02/01/2010,01/31/2011,PA-08-149,1R13AI085574-01,,NIAID:3000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"WARD, ELIZABETH SALLY;",3153331;,1R13AI085574,02/01/2010,01/31/2011,"Academia; Antibodies; Area; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; Biology; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Cellular biology; Collaborations; Communicable Diseases; Complement; Complement Proteins; Development; Engineering; Engineerings; Fostering; Goals; Health; Human; Human, General; Industry; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Lead; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Pb element; Posters; Posters [Publication Type]; Process; Programs (PT); Programs [Publication Type]; RFP; Request for Proposals; Research; Scanning; Scientist; TXT; Text; Therapeutic; Therapeutic antibodies; abstracting; antibody engineering; base; cell biology; conference; heavy metal Pb; heavy metal lead; improved; malignancy; meetings; neoplasm/cancer; novel; posters; programs; self recognition (immune); symposium",2010 Antibody Biology and Engineering Gordon Research Conference," Antibodies represent a rapidly expanding class of therapeutics to treat cancer, autoimmunity, infectious diseases and other illnesses. The Gordon Research Conference on Antibody Biology and Engineering will cover topics that range from basic aspects of B cell biology to the application of therapeutic antibodies. As such, the conference should foster the development of improved and/or novel antibody-based therapeutics.",85574,ZAI1,Special Emphasis Panel,,1,3000,
7798333,R13,AI,1,,01/15/2010,12/31/2010,PA-08-149,1R13AI085592-01,,NIAID:5000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085592,01/15/2010,12/31/2010,"ATGN; Antigen Receptors; Antigens; Area; Autoimmune Status; Autoimmunity; Blast Transformation; Blastogenesis; Cell Communication and Signaling; Cell Signaling; Cell Transplants; Cells; Cellular Matrix; Cellular biology; Chromatin; Chronic; Clinical; Colorado; Communicable Diseases; Complex; Cytoskeletal System; Cytoskeleton; Development; Disease; Disorder; Enzymes; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; INFLM; Immune response; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Intracellular Communication and Signaling; Learning; Lymphoblast Transformation; Lymphocyte; Lymphocyte Activation; Lymphocyte Stimulation; Lymphocyte Transformation; Lymphocytic; Mediating; Organ; Organelles; Pathway interactions; Process; Receptor Protein; Receptors, Antigen; Research; Scanning; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; TXT; Text; Transplantation Immunology; Transplants, Cell; abstracting; biological signal transduction; cell biology; cell transformation; conference; disease/disorder; host response; hypoimmunity; immune deficiency disorder; immunodeficiency; immunogen; immunoresponse; infectious organism; intracellular skeleton; lymph cell; meetings; neoplasm immunology; new therapeutics; next generation therapeutics; novel therapeutics; pathway; receptor; self recognition (immune); symposium; transformed cells; tumor immunology",Lymphocyte Activation and Gene Expression," PROJECT NARRATIVE The topics covered in the 2010 Keystone Symposia meeting on Lymphocyte Activation and Gene Expression have direct relevance to a number of clinically important areas, including autoimmunity, immunodeficiency diseases, transplantation immunology, tumor immunology, infectious diseases, and chronic inflammation. Moreover, these mechanisms and pathways represent a major source of target leads for the development of new therapeutics to treat immunological disorders.",85592,ZAI1,Special Emphasis Panel,,1,5000,
7798801,R13,AI,1,,10/01/2009,09/30/2010,PA-08-149,1R13AI085595-01,,NIAID:10000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"HAAKE, DAVID A;",1898308;,1R13AI085595,10/01/2009,02/28/2011,"Address; Area; Arts; B. burgdorferi; B.burgdorferi; Bacteria; Basic Research; Basic Science; Biology; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; Bovine Species; California; Cattle; Collaborations; Dermatitis; Development; Disease; Disorder; Dysentery; Ensure; Eubacterium; Faculty; Family suidae; Funding; Genetic; Genomics; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Human; Human, General; Immunobiology; Immunophysiology; In Vitro; Infectious Diarrheal Disease; International; Investigators; Leptospira; Leptospirosis; Lyme Borreliosis; Lyme Disease; Lyme Disease Spirochete; Man (Taxonomy); Man, Modern; MeSH Descriptors Class 4; Methods; Methods and Techniques; Methods, Other; Minority; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutritional Requirements; Oral; Order Spirochaetales; Parodontosis; Participant; Pathogenesis; Periodontal Diseases; Physiology; Pigs; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Process; Relapsing Fever; Research; Research Associate; Research Personnel; Researchers; Scanning; Scientist; Spirochaetales; Spirochetes; Structure; Suidae; Swine; Syphilis; T. denticola; T. pallidum; T.denticola; T.pallidum; TXT; Techniques; Text; Travel; Treponema denticola; Treponema pallidum; Underrepresented Minority; United States National Institutes of Health; Woman; abstracting; bovid; bovine; conference; cow; digital; disease/disorder; forging; functional genomics; genetic manipulation; geographic site; graduate student; great pox; interest; lyme spirochete; meetings; nutrient requirement; pathogen; periodontal disorder; periodontium disease; periodontium disorder; porcine; post-doc; post-doctoral; posters; suid; symposium; under-represented minority; underserved minority; working group","2009 Spirochetes, Biology of"," This conference will address diseases caused by spirochetes, including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Participants will include, but not be limited to, women and/or other minorities.",85595,ZAI1,Special Emphasis Panel,,1,10000,
7798744,R13,AI,1,,01/15/2010,12/31/2010,PA-08-149,1R13AI085598-01,,NIAID:7000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085598,01/15/2010,12/31/2010,"Address; Alberta; Alberta province; Animal Model; Animal Models and Related Studies; Area; Articulation; Basic Research; Basic Science; Canada; Chronic; Educational workshop; Fostering; Foundations; Generations; HIV vaccine; HIV/AIDS Vaccines; Health; Human; Human, General; Immune; Immune response; Immunity; Immunologist; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Infection; Investigators; Joints; Man (Taxonomy); Man, Modern; Memory; Process; Research; Research Personnel; Researchers; Role; Scanning; TXT; Text; Therapeutic Intervention; Therapy, Vaccine; Time; Translations; VAC-TX; Vaccine Design; Vaccine Therapy; Viral; Viral Vaccines; Workshop; abstracting; conference; design; designing; host response; human immunodeficiency virus vaccine; immunoresponse; improved; intervention therapy; meetings; model organism; pathogen; social role; symposium; virus host interaction",Viral Immunity," PROJECT NARRATIVE Basic viral immunology research provides the essential foundation for understanding virus-host interaction and the rational design of anti-viral vaccines and therapies that bolster host anti-viral immunity. The Keystone Symposia meeting on Viral Immunity aims to 1) address gaps remaining in our understanding of basic features of anti-viral immunity, and 2) encourage translation of what is now known into improved vaccines and therapies. For the first time, the viral symposium is being convened jointly with the Keystone Symposia meeting on HIV Vaccines in order to introduce the latest advances in basic research to the HIV vaccine field.",85598,ZAI1,Special Emphasis Panel,,1,7000,
7800846,R13,AI,1,,02/01/2010,01/31/2011,PA-08-149,1R13AI085733-01,,NIAID:13500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085733,02/01/2010,01/31/2011,"Address; Anti-Infective Agents; Anti-Infective Drugs; Anti-Infectives; Anti-infective Preparation; AntiInfective Drugs; AntiInfectives; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotic Therapy; Antibiotic Treatment; Antibiotics; Antiinfective Agents; Arts; Awareness; Awarenesses; Biochemistry; Biology; Chemistry; Chemistry, Biological; Clinical; Communicable Diseases; Communication; Data; Development; Discipline; Drug Industry; Drugs; Engineering; Engineerings; Environment; Evolution; Face; Future; Generalized Growth; Genome; Genomics; Growth; Human Microbiome; Industry; Industry, Pharmaceutic; Infection; Infection Control; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Investments; Lead; Learning; Medication; Medicine; Microbial Physiology; Miscellaneous Antibiotic; New Mexico; Participant; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Postdoc; Postdoctoral Fellow; Problem Solving; Process; Research Associate; Research Personnel; Researchers; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Role; Science of Chemistry; Science of Medicine; Site; Solutions; Source; Students; Technology; Time; Tissue Growth; Virulence; Work; anti-microbial agent; anti-microbial drug; antibiotic resistant; antimicrobial agent; antimicrobial drug; communicable disease control agent; conference; disease control; disorder control; drug development; drug discovery; drug/agent; facial; heavy metal Pb; heavy metal lead; innovate; innovation; innovative; meetings; microbial; multidisciplinary; new technology; next generation; ontogeny; pathogen; post-doc; post-doctoral; resistance mechanism; resistant; resistant mechanism; social role; symposium; treatment of bacterial diseases; treatment of bacterial infectious disease",Antibiotics and Resistance: Challenges and Solutions,PROJECT NARRATIVE  The cycle of antibiotic discovery and resistance represents a growing challenge faced by clinicians and the  pharmaceutical sector across the globe. The Keystone Symposia meeting on Antibiotics and Resistance:  Challenges and Solutions will bring together a broad spectrum of researchers to discuss short and long term  solutions to this challenge. Topics under discussion at this meeting have the potential to expand our  understanding of the evolution and function of antibiotics and to inform next generation drug discovery.,85733,ZAI1,Special Emphasis Panel,,1,13500,
7802766,R13,AI,1,,01/15/2010,12/31/2010,PA-08-149,1R13AI085738-01,,NIAID:8000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085738,01/15/2010,12/31/2010,"ATGN; Address; Adipocytes; Adipose Cell; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Antigen Receptors; Antigens; Antiinflammatories; Antiinflammatory Agents; Apoptotic; Attention; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; Biologic Therapy; Biological Response Modifier Therapy; Biological Therapy; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cells; Clinical Investigator; Cytotoxic cell; Diamond; Diathesis; Disease; Disease susceptibility; Disorder; Early treatment; Event; Fat Cells; INFLM; Immune; Immune Tolerance; Immune system; Immunocompetence; Immunologic Competence; Immunologic Tolerance; Immunological Competence; Individual; Inflammation; Inflammatory; Injury; Intervention; Intervention Strategies; Investigators; K lymphocyte; Knowledge; Lead; Lipocytes; Lymphocyte; Lymphocytic; Mature Lipocyte; Mature fat cell; NK Cells; Natural Killer Cells; Nature; New Mexico; Pathway interactions; Pb element; Peripheral; Phase; Predisposition gene; Process; Programs (PT); Programs [Publication Type]; Receptor Signaling; Receptors, Antigen; Regulation; Research; Research Personnel; Researchers; Source; Susceptibility Gene; Tissues; abstracting; autoimmune disorder; autoreactivity; biotherapeutics; biotherapy; body system, allergic/immunologic; cholinergic; chromatin remodeling; conference; cytokine; disease/disorder; disease/disorder proneness/risk; heavy metal Pb; heavy metal lead; human disease; immune system tolerance; immune unresponsiveness; immunogen; immunogenic; immunological paralysis; improved; interventional strategy; liability to disease; lymph cell; meetings; model organism; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathway; predisposing gene; programs; response; self recognition (immune); symposium",Tolerance and Autoimmunity,"PROJECT NARRATIVE  The very modest advances over the past decade in therapy for autoimmune diseases necessitates a rethinking  about errors in regulation of the immune system and the nature of the tissue responses that ultimately lead to  autoimmune disease. Moreover, novel biologic therapies have proven to be less efficacious than hoped. The  Keystone Symposia meeting on Tolerance and Autoimmunity will bring together basic, translational and clinical  investigators to explore new observations in immune tolerance and autoimmunity research with the aim of  developing new perspectives on autoimmune diseases and new approaches to therapies for these diseases.",85738,ZAI1,Special Emphasis Panel,,1,8000,
7804043,R13,AI,1,,02/01/2010,01/31/2011,PA-08-149,1R13AI085778-01,,NIAID:14500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085778,02/01/2010,01/31/2011,"Address; Antiviral Agents; Antiviral Drugs; Antivirals; Biological; Biology; Categories; Cells; Cellular biology; Communities; DNA Viruses; DNA, Viral; Epidemiologic Methods; Epidemiological Methods; Epidemiological Techniques; Epidemiology, Methods; Future; Goals; Investigators; Molecular; Nature; New Mexico; Pathogenesis; Pathway interactions; Process; RNA Viruses; Research Personnel; Researchers; Scanning; Science of Virology; TXT; Text; Viral Diseases; Virology; Virus; Virus Diseases; Viruses, General; abstracting; cell biology; conference; design; designing; meetings; novel; pathway; response; symposium; viral DNA; viral infection; virology; virus DNA; virus infection","Cell Biology of Virus Entry, Replication and Pathogenesis"," PROJECT NARRATIVE Many important aspects of virus biology remain unsolved for both well-studied and emerging viruses. Future progress and new antiviral strategies require detailed understanding of the virus and its interactions with the host cell. The Keystone Symposia meeting on Cell Biology of Virus Entry, Replication and Pathogenesis will bring together an interdisciplinary community of researchers to address the multiple experimental approaches essential for the field of virology to advance.",85778,ZAI1,Special Emphasis Panel,,1,14500,
7803870,R13,AI,1,,01/15/2010,12/31/2010,PA-08-149,1R13AI085791-01,,NIAID:7000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13AI085791,01/15/2010,12/31/2010,"Address; Alberta; Alberta province; Animals; Area; Arts; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoregulation; Biological Models; Biology; Canada; Cancers; Cells; Development; Disease; Disorder; Forms Controls; Homeostasis; INFLM; Immunity; Infection; Inflammation; Inflammatory; Investigation; Investigators; Knowledge; Link; Macrophage Activation; Malignant Neoplasms; Malignant Tumor; Metabolic Diseases; Metabolic Disorder; Model System; Models, Biologic; Molecular; Organism-Level Process; Organismal Process; Outcome; Pathogenesis; Physiologic Processes; Physiological Homeostasis; Physiological Processes; Play; Process; Regulation; Research Personnel; Researchers; Role; Scanning; Sterility; TXT; Text; Thesaurismosis; Work; Wound Healing; Wound Repair; abstracting; atheromatosis; atherosclerotic vascular disease; conference; disease/disorder; insight; macrophage; malignancy; meetings; metabolism disorder; neglect; neoplasm/cancer; pathogen; sensor; social role; sterile; symposium; tissue repair; trafficking",The Macrophage: Intersection of Pathogenic and Protective Inflammation," PROJECT NARRATIVE Macrophages have vital roles in virtually every disease process. Understanding the development, trafficking and regulation of macrophages is therefore an important component of understanding disease and normal physiological process. The Keystone Symposia meeting on The Macrophage: Intersection of Pathogenic and Protective Inflammation will address several gaps in knowledge in the field of macrophage biology through a focus on whole animal studies of infection where macrophages play essential roles in the outcome of protective or pathogenic immunity.",85791,ZAI1,Special Emphasis Panel,,1,7000,
7916313,R13,AI,1,,01/15/2010,02/28/2011,PA-08-149,1R13AI088886-01,,NIAID:7000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,PEDIATRICS,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"UITTENBOGAART, CHRISTEL H.;",1869095;,1R13AI088886,01/15/2010,02/28/2013,"Address; Autoimmune Diseases; Autoimmune Responses; Autoimmune Status; Autoimmunity; Cell Communication and Signaling; Cell Signaling; Collaborations; Development; Goals; Immune; Immune response; Immune system; Immunologist; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Infection; Intracellular Communication and Signaling; Investigators; Molecular; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Regulation; Research Associate; Research Personnel; Researchers; Role; SCHED; Schedule; Scientist; Senior Scientist; Signal Transduction; Signal Transduction Systems; Signaling; T-Cell Subsets; T-Lymphocyte Subsets; Time; autoimmune disorder; base; biological signal transduction; body system, allergic/immunologic; combat; conference; graduate student; host response; human disease; immunoresponse; insight; meetings; novel; organ system, allergic/immunologic; pathogen; post-doc; post-doctoral; postdoctoral investigator; programs; self recognition (immune); social role; symposium; tumor",2010 Midwinter Conference of Immunologists at Asilomar," Project Narrative The major objective of the Midwinter Conference of Immunologists is to provide an annual scientific meeting conducive to interaction among established senior scientists with new investigators, postdoctoral and graduate students. The goal of the conference is to communicate the most recent developments in the field of immunology. The conference schedule will allow ample time for discussion, exchange of ideas and establishment of collaborations. The 2010 conference promises to be as successful as the previous 48 Midwinter Conferences to generate novel ways to explore the immune system, which will benefit studies of human diseases in general and infectious and autoimmune diseases in particular.",88886,ZAI1,Special Emphasis Panel,,1,7000,
7917138,R13,AT,1,,04/01/2010,10/01/2010,PA-08-149,1R13AT005420-01A1,,NCCAM:30000;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,EVANSTON,UNITED STATES,,09,826022100,US,IL,602014695,"MASSAGE THERAPY FOUNDATION, INC.","THOMPSON, DIANA L.;",9714689;,1R13AT005420,04/01/2010,10/01/2010,"Address; Applications Grants; Area; Clinical; Collaborations; Communities; Complementary and alternative medicine; Decision Making; Educational workshop; Environment; Evidence based treatment; Foundations; Grant Proposals; Grants, Applications; Integrative Medicine; Investigators; Manuals; Marshal; Massage; Medical; Methods and Techniques; Methods, Other; Posters; Posters [Publication Type]; Public Health; Research; Research Personnel; Researchers; Structure; Techniques; Therapeutic Studies; Therapy Research; Training; Translating; Translatings; Translations; Workshop; clinical practice; clinical relevance; clinically relevant; conference; evidence base; integrative healing; language translation; literacy; massage therapy; posters; public health medicine (field); public health relevance; symposium",The 2010 Highlighting Massage Therapy in Complementary and Integrative Medicine C," Massage)Therapy)Foundation)R13)Conference)Grant)Proposal)to)NCCAM)  Research)and)Related:)Other)Project)Information)  Section)7:)Project)Narrative)-)Statement)of)Public)Health)Relevance) ) The)conference)proposed)in)this)application)will)contribute)to)the)public)health)by) deepening)the)research)literacy)and)translational)competency)of)manual)therapists,) leading)to)more)evidence-based)treatment.))This)conference)will)also)help)catalyze)a) more)clinically)relevant)body)of)CIM)research)and,)by)convening)researchers)from) highly)diverse)backgrounds,)will)reduce)duplicative)research)efforts)and)increase)the) overall)evidence)base)of)manual)therapy.))Finally,)this)conference)will)host)discussions) directly)focused)on)the)public)health)potential)of)massage)and)related)manual)therapies,) which)are)among)the)most)widely)consumed)forms)of)complementary)and)alternative) medicine)in)the)world.)",5420,ZAT1,Special Emphasis Panel,A1,1,30000,
7799468,R13,CA,1,,02/01/2010,01/31/2011,PA-08-149,1R13CA144225-01,,NCI:3000;NIEHS:2000;,2010,NATIONAL CANCER INSTITUTE,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13CA144225,02/01/2010,01/31/2011,"Address; Apoptosis; Apoptosis Pathway; Automobile Driving; Cancer Biology; Cancer Diagnostics; Cancer Induction; Cancer of Cervix; Cancer of the Fundus of the Stomach; Cancer of the Gastric Body; Cancer of the Gastric Cardia; Cancer of the Gastric Fundus; Cancer of the Gastric Pylorus; Cancer of the Pylorus of the Stomach; Cancer of the Uterine Cervix; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cervical Cancer; Cervix Cancer; Chronic; Collaborations; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Colorado; DNA Damage; DNA Injury; Development; Diagnostics, Cancer; Drivings, Automobile; Elements; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Fostering; Gastric Cancer; Generalized Growth; Genetic; Goals; Growth; HPV; Helicobacter Infections; Helicobacter Pylori Infection; Human Papillomavirus; INFLM; Immune; Immune system; Immunologic Receptors; Immunological Receptors; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Infection; Infectious Human Wart Virus; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intracellular Communication and Signaling; Investigators; Lead; Light; Link; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Gastric Neoplasm; Malignant Gastric Tumor; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Tumor of the Stomach; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of cervix uteri; Malignant neoplasm of stomach; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular; Molecular and Cellular Biology; Neoplasm Metastasis; Neoplastic Processes; Oncogenesis; Papilloma Virus, Human; Papillomavirus, Human; Pathogenesis; Pathway interactions; Pb element; Photoradiation; Plant Embryos; Play; Postdoc; Postdoctoral Fellow; Process; Production; Receptors, Immunologic; Reporting; Research; Research Associate; Research Personnel; Researchers; Resistance; Role; Science; Scientist; Secondary Neoplasm; Secondary Tumor; Seeds; Signal Transduction; Signal Transduction Systems; Signaling; Stomach Cancer; Students; Technology; Therapeutic; Tissue Growth; Tumor Cell Migration; Work; Zygotes, Plant; bench bed side; bench bedside; bench to bed side; bench to bedside; biological signal transduction; body system, allergic/immunologic; cancer metastasis; cancer progression; carcinogenesis; cohort; conference; cytokine; driving; heavy metal Pb; heavy metal lead; immune receptor; interest; malignancy; malignant stomach neoplasm; meetings; neoplasm progression; neoplasm/cancer; neoplastic progression; next generation; ontogeny; organ system, allergic/immunologic; pathway; post-doc; post-doctoral; resistant; seed; social role; symposium; tumor; tumor growth; tumor initiation; tumor progression; tumorigenesis; wart virus",Role of Inflammation in Oncogenesis,"PROJECT NARRATIVE  Recent studies are shedding a new light on the way in which innate resistance, as an integral part of  inflammation, participates in oncogenesis and tumor surveillance. The goal of the Keystone Symposia meeting  on Role of Inflammation in Oncogenesis is to bring together investigators from many distinct fields in order to  facilitate new ideas regarding the means by which inflammation impacts tumor initiation and progression. The  science discussed here has the potential to seed the generation of the next cohort of anti-cancer diagnostics  and therapeutics.",144225,ZCA1,Special Emphasis Panel,,1,5000,
7800639,R13,CA,1,,01/20/2010,12/31/2010,PA-08-149,1R13CA144312-01,,NCI:10000;,2010,NATIONAL CANCER INSTITUTE,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"MORGAN, WILLIAM F.;",1897671;,1R13CA144312,01/20/2010,12/31/2010,"Address; Basic Research; Basic Science; Biological; Cancer Radiotherapy; Cancer Treatment; Cellular Stress; Collaborations; Coupled; DNA Damage Repair; DNA Repair; Development; Electromagnetic Radiation, Ionizing; Fostering; Goals; Human; Human, General; International; Investigators; Ionizing radiation; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Modality; Patients; Physicians; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Radiation Oncology; Radiation therapy; Radiation-Ionizing Total; Radiotherapeutics; Radiotherapy; Research; Research Associate; Research Personnel; Researchers; Role; Scientist; Shapes; Students; Suggestion; Targeted Radiotherapy; Therapeutic Effect; Translating; Translatings; Unscheduled DNA Synthesis; Work; anticancer therapy; base; biological adaptation to stress; cancer therapy; clinical applicability; clinical application; conference; irradiation; language translation; meetings; novel; palliative; peer; post-doc; post-doctoral; programs; reaction; crisis; social role; stress response; stress; reaction; symposium; tumor",2010 Radiation Oncology Gordon Research Conference,"Gordon Research Conference on Radiation Oncology 2009 Narrative  During cancer therapy approximately 60% of all patients will be treated with ionizing  radiation, to either cure the tumor or for palliative reasons. The Gordon Research  Conference on Radiation Oncology covers the biological basis of the therapeutic effects  of ionizing radiation. The exciting advances in basic research coupled with novel  technological modalities for delivering targeted radiotherapy will be showcased with  emphasis on translating new developments to the patient.  Public",144312,ZCA1,Special Emphasis Panel,,1,10000,
7795339,R13,EY,1,,02/01/2010,01/31/2011,PA-08-149,1R13EY020033-01,,NEI:30000;,2010,NATIONAL EYE INSTITUTE,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"CHAKRAVARTI, SHUKTI ;",1977429;,1R13EY020033,02/01/2010,01/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Anterior; Area; Biology; Biomechanics; Biomimetics; Blindness; Body Tissues; Clinical; Contact Lenses; Cornea; Disease; Disorder; Equilibrium; Eye; Eyeball; Eyelid structure; Eyelids; Fees; Funding; Gene Action Regulation; Gene Delivery; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genetic Research; Genomics; Hydration; Hydration status; Image; Immune response; Immunomodulation; Infection; Injury; Investigators; Lacrimal Glands; Lacrimal gland structure; Light; Meibomian Glands; Mimetics, Biological; Molecular and Cellular Biology; Operation; Operative Procedures; Operative Surgical Procedures; Palpebra; Participant; Photoradiation; Play; Postdoc; Postdoctoral Fellow; Property; Property, LOINC Axis 2; Proteomics; QOL; Quality of life; Research; Research Associate; Research Personnel; Researchers; Role; Secure; Sight; Staging; Structure of meibomian gland; Students; Surgical; Surgical Interventions; Surgical Procedure; Tarsal Glands; Time; Tissues; Transgenic Animals; Travel; Vision; angiogenesis; balance; balance function; career; conference; conjunctiva; corneal; cost; disease/disorder; frontier; graduate student; host response; imaging; immune modulation; immunologic reactivity control; immunoregulation; immunoresponse; insight; meetings; meibomian gland; model organism; ocular surface; post-doc; post-doctoral; public health relevance; regenerative; skills; social role; stem cell biology; surgery; symposium",2010 Biology and Pathobiology of The Cornea, This biennial Gordon Research Conference on the Biology and pathobiology of the cornea will make a huge impact on the field by providing a well-known conference setting for investigators with diverse expertise and at different career stages to meet and push the frontiers of cornea research.,20033,ZEY1,Special Emphasis Panel,,1,30000,
7980301,R13,FD,1,,01/28/2010,12/31/2010,FD-08-003,1R13FD003878-01,,FDA:;,2010,FOOD AND DRUG ADMINISTRATION,,SALT LAKE CITY,UNITED STATES,,01,,US,UT,841146500,"NATIONAL EGG REGULATORY OFFICIALS, INC.","STRAW, MARK ;",9662135;,1R13FD003878,01/28/2010,12/31/2010,,National EGG Regulatory Officials 18th Annual Conference and Training Seminar,,3878,ZFD1,Special Emphasis Panel,,1,25000,
7995634,R13,FD,1,,01/28/2010,12/31/2010,FD-08-003,1R13FD003882-01,,FDA:;,2010,FOOD AND DRUG ADMINISTRATION,,PORTLAND,UNITED STATES,,03,,US,OR,972151042,CONFERENCE FOR FOOD PROTECTION,"PIPPERT, ERIC ;",10304889;,1R13FD003882,01/28/2010,12/31/2010,,conference  for food protection 2010 binnial meeting,,3882,ZFD1,Special Emphasis Panel,,1,25000,
7804872,R13,HD,1,,01/11/2010,01/10/2011,PA-08-149,1R13HD063228-01,,NICHD:6000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13HD063228,01/11/2010,01/10/2011,"Animals; Biogenesis; Biological; Biology; Cancers; Development; Developmental Gene; Eukaryota; Eukaryote; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene, Developmental; Genome Stability; Goals; Guide RNA; Immunity; Learning; Logic; Malignant Neoplasms; Malignant Tumor; Methods; Micro RNA; MicroRNAs; Molecular; Origin of Life; Pathway interactions; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Guide; RNA, Small Interfering; RNAi; Regulation; Research; Role; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Small RNA; Stability, Genomic; Therapeutic; base; conference; eukaryotida; gRNA; gRNA (guide RNA); gene discovery; malignancy; meetings; miRNA; neoplasm/cancer; pathway; plant fungi; public health relevance; siRNA; social role; symposium","RNA Silencing: Mechanism, Biology and Application"," PROJECT NARRATIVE RNA silencing pathways function in RNA-based immunity, developmental gene regulation, transcriptional silencing, and genomic stability. For instance, miRNAs play critical roles in virtually every biological pathway, although their roles in development and cancer have received special notice. The study of RNA silencing encompasses research in fungi, plants, basal eukaryotes, and animals. A key goal of The Keystone Symposia meeting on RNA Silencing: Mechanism, Biology and Application will be to highlight the unexpected, and often unexplained, complexity in the interactions between distinct small RNA pathways.",63228,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,6000,
7805092,R13,HD,1,,02/01/2010,01/31/2011,PAR-09-092,1R13HD063283-01,,NICHD:6000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEWARK,UNITED STATES,OTHER HEALTH PROFESSIONS,00,059007500,US,DE,19716,UNIVERSITY OF DELAWARE,"DAVIS, IRENE S;",7849265;,1R13HD063283,02/01/2010,01/31/2011,"Articulation; Biomechanics; Body Tissues; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Migration; Classification; Communities; Community Participation; Complex; Delaware; Dyskinesia Syndromes; Educational workshop; Examination of gait; Extremities; Future; Gait Analysis; Goals; Health; Human; Human, General; International; Investigation; Investigators; Joints; Journals; Kinesiology; Knowledge; Limb structure; Limbs; Magazine; Man (Taxonomy); Man, Modern; Mechanics; Motility; Motility, Cellular; Movement; Movement Disorder Syndromes; Movement Disorders; Movement science; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neurologic; Neurological; Non-Trunk; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Outcome; Paper; Participant; Participation, Community; Position; Positioning Attribute; Publications; Recommendation; Reporting; Research; Research Personnel; Researchers; Scientific Publication; Scientist; Sight; Structure; System; System, LOINC Axis 4; Systematics; Technology; Tissues; United States National Institutes of Health; Universities; Vision; WHO; Workshop; World Health Organization; Writing; base; body mechanics; body movement; cell motility; disability; gait examination; mechanistic (body); meetings; neuromusculoskeletal; novel; social",NIH-BIOMECHANICS IN MOVEMENT SCIENCE: BUILDING TRANSDOMAIN BRIDGES,"The study of human movement requires the investigation of mechanics of cells and tissues, joints, limbs, and  whole body movements. The purpose of this proposed meeting is to develop and prioritize a set of  recommendations pertaining to biomechanics and movement science research that is trans-domain and  translational in nature. The overarching goal is to provide the roadmap for this research for the next decade.",63283,CHHD,National Institute of Child Health and Human Development Initial Review Group,,1,6000,
7797041,R13,HL,1,,02/01/2010,01/31/2011,PA-08-149,1R13HL098974-01,,NHLBI:10000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"SCHWARTZ, BRADFORD S;",1875288;,1R13HL098974,02/01/2010,01/31/2011,"Achievement; Achievement Attainment; Alteplase; Apoplexy; Area; Autoregulation; Basic Research; Basic Science; Biology; Blood Vessels; Body Tissues; California; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical Research; Clinical Study; Collaborations; Deep Vein Thrombosis; Deep-Venous Thrombosis; Development; Discipline; Disease; Disorder; Dysfunction; EC 3.4.21.7; Esteroproteases; Functional disorder; Funding; Funding Applicant; Goals; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Homeostasis; Intermediary Metabolism; International; Investigators; Lead; Location; METBL; Metabolic Processes; Metabolism; Myocardial Infarct; Myocardial Infarction; Natural regeneration; Nervous System Physiology; Nervous System, CNS; Neuraxis; Neurologic function; Neurological function; Obesity; Organ System, Cardiovascular; PLAT; Participant; Pb element; Peptidases; Peptide Hydrolases; Physiological Homeostasis; Physiopathology; Plasminogen; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Profibrinolysin; Proteases; Protein Cleavage; Proteinases; Proteolysis; Proteolytic Enzymes; Recombinant Tissue Plasminogen Activator; Regeneration; Research; Research Associate; Research Personnel; Researchers; Scientist; Stroke; System; System, LOINC Axis 4; T-Plasminogen Activator; TTPA; Tissue Activator D-44; Tissue Plasminogen Activator; Tissue-Type Plasminogen Activator; Tissues; Translating; Translatings; Tumor Biology; Underrepresented Minority; Vascular Accident, Brain; Vascular, Heart; Woman; adiposity; angiogenesis; brain attack; cardiac infarct; cerebral vascular accident; circulatory system; conference; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; disease/disorder; experience; extracellular; frontier; graduate student; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; human disease; innovate; innovation; innovative; language translation; nervous system function; novel; obese; obese people; obese person; obese population; pathophysiology; peer; post-doc; post-doctoral; posters; public health relevance; regenerate; stem cell biology; stroke; symposium; t-PA; thrombolysis; under-represented minority; underserved minority; vascular",2010 Gordon Research Conference on Plasminogen Activation and Ertracellular Prote," Project Narrative Plasminogen activation and extracellular proteolysis are rapidly advancing research areas that intersect with basic science and clinical research. Research in these areas is uniquely important for the development of new ways to treat a wide range of disorders related to the circulatory system, including heart attack, deep vein thrombosis, and occlusive stroke. The conference will bring together the leading researchers in the world to discuss their latest research in this area, with the goal of translating these discoveries into new and better treatment of human disease.",98974,ZHL1,Special Emphasis Panel,,1,10000,
7803943,R13,HL,1,,02/01/2010,01/31/2011,PA-08-149,1R13HL099157-01,,NHLBI:15500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13HL099157,02/01/2010,01/31/2011,"Address; Area; Basic Research; Basic Science; Biology; Blood Vessels; Cancer, Oncology; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Clinical; Clinical Research; Clinical Study; Colorado; Development; Developmental Biology; Discipline; Disease; Disorder; Educational workshop; Genetic; Health; Intracellular Communication and Signaling; Investigators; Medicine; Nature; Nervous; Ophthalmology; Organ System, Cardiovascular; Posters; Posters [Publication Type]; Process; Research; Research Personnel; Researchers; Science of Medicine; Scientist; Signal Transduction; Signal Transduction Systems; Signaling; Time; Vascular, Heart; Workshop; angiogenesis; base; biological signal transduction; circulatory system; conference; disease/disorder; interest; meetings; neural; oncology; posters; public health relevance; relating to nervous system; repair; repaired; symposium; vascular",Angiogenesis in Health and Disease," PROJECT NARRATIVE Angiogenesis continues to occupy a central place in many disciplines including cardiovascular medicine, oncology, ophthalmology and many others. Recent advances in developmental biology, genetics and signaling are leading to a new understanding of how blood vessels are forming and new ideas for stimulating and inhibiting this process. This meeting will bring together leading researches in this field and related basic science and clinical disciplines to discuss the new concepts, exchange the most up-to date information and formulate new strategies.",99157,ZHL1,Special Emphasis Panel,,1,15500,
7804073,R13,HL,1,,01/05/2010,01/04/2011,PA-08-149,1R13HL099162-01,,NHLBI:18000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13HL099162,01/05/2010,01/04/2011,"Academia; Adipose tissue; Affect; Anabolism; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biology; Body Tissues; Cells; Chylomicrons; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials, Unspecified; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; DNA Molecular Biology; Data; Development; Disease; Disorder; Fatty Acids, Nonesterified; Fatty Tissue; Free Fatty Acids; Genetic; Health; Humulin R; Hyperglyceridemia; Hypertriglyceridemia; Industry; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intestinal; Intestines; Lipids; Lipolysis; Lipoproteins; Lipoproteins, VLDL; Liver; METBL; Medicine; Metabolic Processes; Metabolism; Molecular Biology; Montana; Nonesterified Fatty Acids; Novolin R; Pathogenesis; Pharmacological Treatment; Play; Population; Prebeta-Lipoproteins; Raised TG; Raised triglycerides; Regulation; Research; Role; Science; Science of Medicine; Scientist; Skiing; Snow Skiing; Tissues; Triacylglycerol; Triglyceride increased; Triglycerides; Triglycerides high; Update; VLDL; Very low density lipoprotein; adipose; atheromatosis; atherosclerotic vascular disease; base; biosynthesis; body system, hepatic; bowel; cardiovascular disease risk; cardiovascular disorder risk; clinical investigation; clinical relevance; clinically relevant; conference; cytokine; disease/disorder; elevated tg; elevated triglyceride; energy balance; insight; meetings; organ system, hepatic; particle; public health relevance; social role; symposium; white adipose tissue; yellow adipose tissue",Triglycerides and Triglyceride-Rich Particles in Health and Disease," PROJECT NARRATIVE Research suggests that triglycerides are a cause of greater coronary artery disease; however, significant questions remain as to whether or not reducing triglyceride levels is protective. Moreover, the data relating the most severe forms of hypertriglyceridemia to development of atherosclerosis are limited. This Keystone Symposia meeting on Triglycerides and Triglyceride-Rich Particles in Health and Disease will assemble leading scientists to discuss 1) the clinical science on causes and treatment of hypertriglyceridemia, and 2) how triglycerides are regulated and affect biology in animals and cells.",99162,ZHL1,Special Emphasis Panel,,1,18000,
7805127,R13,HL,1,,02/01/2010,01/31/2011,PA-08-149,1R13HL099225-01,,NHLBI:15500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SILVERTHORNE,UNITED STATES,,02,079780750,US,CO,80498,KEYSTONE SYMPOSIA,"ROBERTSON, ANDREW D;",1896881;,1R13HL099225,02/01/2010,01/31/2011,"21+ years old; Adult; Aging; Automobile Driving; Autophagocytosis; Back; Blood Vessels; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Aging; Cell Lineage; Cell Senescence; Cell Transplants; Cells; Cellular Aging; Cellular biology; Clinical; Clinical Research; Clinical Study; Colorado; Companions; Cues; Defect; Development; Disease; Disorder; Dorsum; Drivings, Automobile; Environment; FLR; Failure (biologic function); Fetal Development; Fetal development of the mammalian embryo or fetus; Genes; HTRPY; Health; Heart; Heart Diseases; Heart myocyte; Human, Adult; Hypertrophy; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Investigators; Life; Mammalia; Mammals; Mammals, General; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardium; Myocytes, Cardiac; Natural regeneration; Organ; Organ System, Cardiovascular; Phenotype; Postdoc; Postdoctoral Fellow; Progenitor Cells; Proliferating; Regeneration; Regenerative Medicine; Research; Research Associate; Research Personnel; Researchers; Scientist; Senescence; Senescence, Cellular; Senescence, Replicative; Stem cells; Students; System; System, LOINC Axis 4; Technology; Tissue Engineering; Transplantation; Transplants, Cell; Vascular, Heart; Vertebrate Animals; Vertebrates; Western World; Work; adult human (21+); angiogenesis; autophagy; bench bed side; bench bedside; bench to bed side; bench to bedside; cardiac muscle; cardiogenesis; cardiomyocyte; cell age; cell biology; circulatory system; conference; design; designing; disease/disorder; driving; elderly patient; engineered tissue; failure; heart development; heart disorder; heart muscle; injured; meetings; older patient; panacea; post-doc; post-doctoral; pre-clinical; pre-clinical research; preclinical; preclinical research; progenitor; public health relevance; regenerate; repair; repaired; senescent; small molecule; stem; symposium; therapeutic target; tool; transplant; vascular; vasculogenesis; vertebrata",Cardiovascular Development and Repair,"PROJECT NARRATIVE  Heart disease remains the leading cause of morbidity and mortality in the western world. Many years of  preclinical research and more recent clinical studies illustrate that cell transplant alone is not the hoped-for  panacea. In order to understand more fully the capability for repair or regeneration in mammalian heart, this  meeting is designed to bring together scientists who study the following: cardiac development; heart systems in  lower vertebrates; stem and progenitor cells or small molecules; aging myocardium; and transplant  immunology, a field that likely will impact the ultimate potential for safe therapies.",99225,ZHL1,Special Emphasis Panel,,1,15500,
7806123,R13,HL,1,,02/01/2010,01/31/2011,PA-08-149,1R13HL099227-01,,NHLBI:7500;OD:15000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOUISVILLE,UNITED STATES,BIOCHEMISTRY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"ELLIS, STEVEN R;",1926343;,1R13HL099227,02/01/2010,01/31/2011,"Award; Biology; Bone Marrow; Bone marrow failure; Breeding; Cancers; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Community Physician; Consensus; Diamond-Blackfan anemia; Discipline; Disease; Disorder; Dysfunction; Environment; FLR; Failure (biologic function); Fostering; Functional disorder; Funding Agency; Funding Source; Hematologist; International; Investigators; Link; Malignant Neoplasms; Malignant Tumor; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pancytopenia; Patient Care; Patient Care Delivery; Physicians; Physiopathology; Rare Diseases; Rare Disorder; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Ribosomes; Role; Scientist; Syndrome; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; base; clinical care; clinical investigation; clinical practice; conference; disease/disorder; failure; human disease; interdisciplinary approach; interest; malignancy; meetings; neoplasm/cancer; pathophysiology; public health relevance; social role; symposium; translation research enterprise",Diamond Blackfan Anemia International Consensus Conference," The Diamond Blackfan Anemia International Consensus Conference is the only meeting held each year that brings together physicians, scientists, and other parties interested in all aspects of Diamond Blackfan anemia. Over the past 10 years this meeting has produced a consensus clinical care document for patient care, helped coordinate clinical trials, stimulated collaborations promoting translational research and fostered an environment which has led to tremendous advances in understanding the underlying molecular basis for Diamond Blackfan anemia. As Diamond Blackfan anemia is the first human disease caused by a failure of ribosome synthesis, an interdisciplinary conference such as this is absolutely essential for bringing together physicians and scientists of diverse disciplines for productive interactions relevant to DBA and broadening applications to other disease states.",99227,ZHL1,Special Emphasis Panel,,1,22500,
7915158,R13,HL,1,,02/01/2010,01/31/2011,PA-08-149,1R13HL102943-01,,NHLBI:25000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DENVER,UNITED STATES,,01,076443019,US,CO,80206,NATIONAL JEWISH HEALTH,"CRAPO, JAMES D;",1897607;,1R13HL102943,02/01/2010,01/31/2011,"ACR; American College of Radiology; Au element; CAT Scan, X-Ray; CAT scan; COAD; COPD; CT X Ray; CT scan; Chest; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Communities; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Consensus; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Disease; Disorder; EMI scan; Education; Educational aspects; Educational workshop; Emphysema; Financial Support; Foundations; Genes; Goals; Gold; Investigators; Lectures; Lectures (PT); Lectures [Publication Type]; Logistics; Lung diseases; Medicine; Normal Range; Normal Values; Participant; Pneumology; Pneumonology; Pulmonary Disease (Specialty); Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Emphysema; Pulmonary Medicine; Pulmonology; Radiology; Radiology Specialty; Radiology, General; Reading; Research Personnel; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Reston; Science of Medicine; Scientist; Severities; Staging; Thorace; Thoracic; Thorax; Time; Tomodensitometry; Tomography, Xray Computed; Virginia; Work; Workshop; Writing; X-Ray Computed Tomography; base; catscan; clinical data repository; clinical data warehouse; computed axial tomography; computerized axial tomography; computerized tomography; conference; data repository; disease/disorder; interest; lectures; lung disorder; public health relevance; relational database; symposium",Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD," Project Narrative: This proposal is for a conference/workshop of leaders in radiology and pulmonology to develop consensus on how to visually score chest CT scans to identify clinically important different types of COPD. This conference will be held at the American College of Radiology Education Center in Reston, Virginia, and will use chest CT scans from COPD subjects created by the COPDGene Project. Creating a consensus for the different important subtypes of COPD is a critical step in developing new therapies and personalized medicine for this major lung disease.",102943,ZHL1,Special Emphasis Panel,,1,25000,
7916273,R13,HS,1,,02/01/2010,12/31/2010,PA-06-378,1R13HS018886-01,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,TEMPLE,UNITED STATES,,31,076697960,US,TX,76504,SCOTT AND WHITE MEMORIAL HOSPITAL,"STEVENS, ALAN B;",1964355;,1R13HS018886,02/01/2010,12/31/2010,,2010 HMO Research Network Annual Conference," Project Narrative The HMO Research Network's annual meetings support the collaborative work of 16 research centers. These research centers are all based in integrated healthcare systems and conduct clinical, epidemiologic, and health services research. These health plans provide the perfect environment for research with their stable populations, electronic medical records, and ability to focus on the whole population or a single patient. The Network's mission is to use its collective capabilities to conduct research that can be easily translated into medical care.",18886,HCRT,HSR Health Care Research Training SS,,1,74692,
7918546,R13,HS,1,,01/15/2010,11/14/2010,PA-06-074,1R13HS018891-01,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,ALEXANDRIA,UNITED STATES,,08,070110986,US,VA,223143402,AMERICAN STATISTICAL ASSOCIATION,"CRANK, KEITH N;",9286164;,1R13HS018891,01/15/2010,11/14/2010,,2010 International Conference on Health Policy Statistics (ICHPS): Quantitative I," The International Conference on Health Policy Statistics: Striving for Consensus on Methods is a scientific conference that focuses on the interplay between health policy and research methodology. Its specific aim is to create an educational and research forum for statisticians, psychometricians, and other experts in research methodology, to engage policy makers and to exchange and build upon ideas, discuss research needs, and develop solutions to methodological challenges",18891,ZHS1,Special Emphasis Panel,,1,27250,
7798684,R13,NS,1,,01/27/2010,12/31/2010,PA-08-149,1R13NS067696-01,,NIMH:3000;NINDS:15000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"MACKLIN, WENDY B;",1891129;,1R13NS067696,01/27/2010,12/31/2010,"21+ years old; Adult; Area; Attention; Biology; Biomedical Research; CNS Diseases; CNS disorder; California; Cells; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Clinical; Data; Development; Disease; Disorder; Ensure; Equilibrium; Faculty; Fostering; Funding; Gender; Goals; Health; Human; Human, Adult; Human, General; In element; Indium; Investigation; Investigators; Link; MS (Multiple Sclerosis); Man (Taxonomy); Man, Modern; Mental disorders; Mental health disorders; Multiple Sclerosis; Myelin; NIH RFA; NRVS-SYS; Nervous; Nervous System; Nervous System, CNS; Nervous system structure; Neural Stem Cell; Neuraxis; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Oral; Pathology; Peripheral Nervous System; Population; Posters; Posters [Publication Type]; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Request for Applications; Research; Research Personnel; Researchers; Scientist; Sclerosis, Disseminated; Travel; Unspecified Mental Disorder; Work; adult human (21+); balance; balance function; conference; design; designing; disease/disorder; dysmyelinating; dysmyelination; human disease; insular sclerosis; meetings; mental illness; myelination; nerve stem cell; nervous system development; neural; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; peer; posters; precursor cell; programs; psychological disorder; public health relevance; relating to nervous system; repair; repaired; stem; stem cell population; symposium",2010 Myelin Gordon Research Conference," Narrative This meeting highlights the advances made in research on myelin in the central and peripheral nervous system. These advances are important both for our understanding of basic mechanisms of nervous system development and function and for its relevance to numerous de/dysmyelinating human diseases, such as multiple sclerosis in the central nervous system. The 2010 meeting will also discuss new data linking underlying myelin pathology with other human neurologic and psychiatric diseases. Our understanding of the biology of myelinating cells in the nervous system continues to expand rapidly, with a particular focus on the fact that the adult CNS contains populations of neural stem/precursor cells capable of generating new myelin. This highlights the potential clinical implications for our investigations on myelination and remyelination.",67696,ZNS1,Special Emphasis Panel,,1,18000,
7914991,R13,RR,1,,02/01/2010,01/31/2011,PA-08-149,1R13RR030762-01,,NCRR:85552;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,COLUMBIA,UNITED STATES,VETERINARY SCIENCES,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"CRITSER, JOHN K.;",2190608;,1R13RR030762,02/01/2010,01/31/2015,"ATCC; Active Follow-up; American Type Culture Collection; Bio-Informatics; Bioinformatics; California; Electronics; Face; Funding; Grant; Intellectual Property; Laboratories; Mails; Mammals, Primates; Marines; Maryland; Medicine; Mission; NCRR; NIH; NIH RFA; National Center for Research Resources; National Institutes of Health; National Institutes of Health (U.S.); Primates; Programs (PT); Programs [Publication Type]; Request for Applications; Research; Research Resources; Resources; Schools; Science; Science of Medicine; Solutions; United States National Institutes of Health; Universities; Update; comparative; conference; facial; follow-up; improved; meetings; programs; symposium",Comparative Medicine Resource Center Director Meetings," Project Narrative This grant will support three conferences over the next five years to convene the Directors of Resource Centers funded by the National Institutes of Health National Center for Research Resources (NIH NCRR). The objectives of the conference are to provide a forum for Directors to discuss common issues and problems relevant to fulfilling the mission of NCRR, to receive input and guidance from NCRR, and to share ideas for common solutions.",30762,ZDK1,Special Emphasis Panel,,1,85552,
7779788,R15,GM,1,,03/01/2010,02/28/2013,PA-06-042,1R15GM086838-01A1,,NIGMS:228000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,CHEMISTRY,03,957447782,US,MA,01610,"CLARK UNIVERSITY (WORCESTER, MA)","CRAMPTON, DONALD ;",9381164;,1R15GM086838,03/01/2010,02/28/2013,"Aging Process; Aging-Related Process; Ally; Arabidopsis; Arabidopsis thaliana; Bacteriophage T7; Bears; Biochemical; Cell Survival; Cell Viability; Chimera Protein; Chimeric Proteins; Coliphage T7; Cress, Mouse-ear; DNA; DNA Helicases; DNA Primase; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA unwinding enzyme; DNA, Mitochondrial; DNA, Single-Stranded; Deoxyribonucleic Acid; Development; Disease; Disorder; Double-Stranded DNA; Employee Strikes; Enterobacteria phage T7; Enzymes; Eukaryota; Eukaryote; Fusion Protein; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Genomics; Human; Human, General; Individual; Life; Link; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Microscopy; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Molecular Biology, Mutagenesis; Monitor; Mouse-ear Cress; Mutagenesis; Mutation; Nature; Organism; Predisposition; Primase; Primer Extension; Process; Proteins; Single-Stranded DNA; Site; Source; Strikes; Strikes, Employee; Susceptibility; T7 Phage; Time; Ursidae; Ursidae Family; disease/disorder; ds-DNA; enzyme activity; eukaryotida; gene product; genome mutation; helicase; human disease; interest; living system; mitochondrial; mitochondrial genome; mtDNA; polypeptide; public health relevance; reconstitute; reconstitution; single molecule",Primase Activity of the Mitochondrial Replisome," PROJECT NARRATIVE Mutations in mitochondrial genomic DNA are associated with a wide range of human diseases as well as the ageing process. We propose to study mitochondrial DNA replication in order to resolve mechanisms of mutagenesis and, potentially, to find ways to decrease the rate of mutation in mitochondrial DNA.",86838,MSFC,Macromolecular Structure and Function C Study Section,A1,1,228000,
7779181,R15,GM,1,,01/15/2010,12/31/2012,PA-06-042,1R15GM087699-01A1,,NIGMS:217826;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MILWAUKEE,UNITED STATES,BIOLOGY,04,046929621,US,WI,532011881,MARQUETTE UNIVERSITY,"NOEL, KENNETH D;",2186850;,1R15GM087699,01/15/2010,12/31/2012,"ABC Transport Protein; ABC Transporter Protein; ABC Transporters; ATP-Binding Cassette Transporters; Accounting; Address; Anabolism; Animals; Bacteria; Base Sequence; Biochemical; Carbohydrates; Cell Extracts; Complex; EC 2; EC 2.4; Environment; Enzymes; Gene Cluster; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Genome; Glycoside Transferases; Gram-Negative Bacteria; In Vitro; LPS; Label; Length; Lesion; Lipid A; Lipopolysaccharides; Liquid substance; Medical; Modeling; Mutate; Mutation; Nucleotide Sequence; O Antigen, Bacterial; O Antigens; O-Specific Polysaccharides; Phaseolus vulgaris; Phosphates; Plants; Plants, General; Property; Property, LOINC Axis 2; Reaction; Rhizobium etli; SUBGP; Specific qualifier value; Specified; Structure; Subgroup; Surface; Symbiosis; Testing; Transferase; Work; bactoprenol; base; bean; biosynthesis; commensalism; experiment; experimental research; experimental study; fluid; genetic analysis; genetic manipulation; genome mutation; glycosyltransferase; in vivo; inorganic phosphate; interest; liquid; mutant; nucleic acid sequence; pathogenic bacteria; public health relevance; research study; sugar; sugar nucleotide",Genetics and biosynthesis of an O antigen essential for symbiosis," Project Narrative  With a model bacterium that does not cause medical problems, this project examines the fundamental basis of a property of health-beneficial and pathogenic bacteria that is crucial to their survival, especially in the hostile confines of the mammalian circulatory fluids. It also is important in other interactions with animal and plant hosts. This property is a type of carbohydrate chain on the surfaces of many bacteria. The question addressed in this work is how this chain is synthesized.",87699,PCMB,Prokaryotic Cell and Molecular Biology Study Section,A1,1,217826,
7778013,R15,GM,1,,02/01/2010,01/31/2013,PA-06-042,1R15GM090228-01,,NIGMS:227250;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ALBANY,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,21,152652822,US,NY,12222,STATE UNIVERSITY OF NEW YORK AT ALBANY,"KUZNETSOV, IGOR B.;",8242580;,1R15GM090228,02/01/2010,01/31/2013,"Accounting; Address; Algorithms; Area; Arts; Au element; Benchmarking; Best Practice Analysis; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Bioinformatics; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Classification; Combining Site; Complex; Computer Analysis; Computer Programs; Computer software; Computers; Computing Methodologies; Consensus; Data; Data Set; Dataset; Descriptor; Disadvantaged; Disease; Disorder; Docking; Environment; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genome; Genomics; Goals; Gold; Health; Human; Human, General; Internet; Intracellular Communication and Signaling; Investigators; Life; Location; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Membrane Proteins; Membrane-Associated Proteins; Method LOINC Axis 6; Methodology; Methods; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nucleic Acids; Outcome; Output; Performance; Process; Property; Property, LOINC Axis 2; Protein Analysis; Proteins; Reactive Site; Research; Research Personnel; Researchers; Resolution; Signal Transduction; Signal Transduction Systems; Signaling; Site; Software; Structure; Surface; Surface Proteins; Systematics; Systems Biology; Testing; United States National Institutes of Health; Universities; Validation; WWW; Work; base; biological signal transduction; computational analysis; computational methodology; computational methods; computer methods; computer program/software; conformation; conformational state; design; designing; disease/disorder; flexibility; functional/structural genomics; gene product; human disease; innovate; innovation; innovative; malignancy; neoplasm/cancer; novel; protein structure; public health relevance; web; web-accessible; world wide web",Computational analysis of protein interaction sites," The proposed research is significant because it will address the fundamental problem of protein-protein and protein-nucleic acid interactions. It will facilitate research areas directly related to human health, including studies of protein interactions involved in various diseases such as cancer.",90228,MSFD,Macromolecular Structure and Function D Study Section,,1,227250,
7778954,R15,HD,1,,01/18/2010,12/31/2012,PA-06-042,1R15HD062979-01,,NICHD:212792;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,HUNTINGTON,UNITED STATES,BIOLOGY,03,036156615,US,WV,25701,MARSHALL UNIVERSITY,"ZHU, GUO-ZHANG ;",7932064;,1R15HD062979,01/18/2010,12/31/2012,"Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Brachydanio rerio; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Contraception, Male; Danio rerio; Data; Defect; Development; Developmental Process; Difficulty conceiving; Disease; Disorder; Ectopic Expression; Education; Educational aspects; Erinaceidae; Family; Family member; Gametes; Genes; Genetic; Genetic, Biochemical; Genital System, Male, Testis; Germ Cells; Germ-Line Cells; Goals; Hedgehog (Hh) signal transduction pathway; Hedgehogs; Human; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Infertility; Institution; Intracellular Communication and Signaling; Knock-out; Knockout; Knowledge; Laboratories; Lead; Ligands; Literature; Male Contraceptions; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Mice; Mice, Mutant Strains; Molecular; Molecular Interaction; Murine; Mus; Mutant Strains Mice; One Step; One-Step dentin bonding system; Organism; Pb element; Play; Process; Proliferating; Proteins; Receptor Protein; Regulation; Reporting; Reproduction; Reproductive Cells; Research; Role; Scholarship; Sertoli Cells; Sex Cell; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sperm; Spermatocytes; Spermatogenesis; Spermatogenic Cell; Spermatozoa; Spermiocytes; Staging; Sterility; Structure of sertoli cell; Students; Sustentacular Cell of Testis; Testicles; Testing; Testis; Vertebrate Animals; Vertebrates; Work; Zebra Danio; Zebra Fish; Zebrafish; base; biological signal transduction; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hedgehog signaling pathway; hh signaling pathway; infertile; initial cell; insight; living system; male; member; membrane structure; men; men's; mouse model; mouse mutant; novel; null mutation; protein expression; public health relevance; receptor; research study; sertoli cell; sexual cell; smoothened signaling pathway; social role; sperm cell; sterile; unable to bear children; vertebrata; zoosperm",Role of Ptchd3 in Spermatogenesis," Results from these studies will advance our knowledge about the regulation of spermatogenesis, may provide insight into unexplained (or idiopathic) infertility in men, and may lead to new strategies for male contraception.",62979,DEV1,Development - 1 Study Section,,1,212792,
7782291,R15,HL,1,,01/29/2010,12/31/2012,PA-06-042,1R15HL098931-01,,NHLBI:206302;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WORCESTER,UNITED STATES,BIOLOGY,03,168704765,US,MA,016022861,WORCESTER STATE COLLEGE,"BRYAN, BRAD ALLEN;",9800174;,1R15HL098931,01/29/2010,12/31/2012,"Actins; Adhesion Molecule; Adverse effects; Age related macular degeneration; Angiogenesis, Pathologic; Angiogenesis, Pathological; Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Assay; Atrophic Arthritis; Attenuated; Avastin; Bevacizumab (rhuMAb VEGF); Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Blindness; Blood Vessels; Blood capillaries; Body Tissues; Cancers; Capillaries; Capillary; Capillary Endothelial Cell; Capillary, Unspecified; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Components; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell Structure; Cell division; Cell physiology; CellLine; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular Structures; Clinical Trials; Clinical Trials, Unspecified; Colorectal Cancer; Cytokines, Chemotactic; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Development; Diabetic Retinopathy; Disease; Disease Progression; Disease remission; Disorder; Distal; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug usage; Drugs; Electron Microscopy; Endothelial Cell, Capillary; Endothelial Cells; Environment; Esteroproteases; Exhibits; Extracellular Matrix Degradation; Foundations; GFAC; Gene Expression; Gene Targeting; General Population; General Public; Generalized Growth; Generations; Genes; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF; Homologous Chemotactic Cytokines; Immunoblot Analysis; Incidence; Individual; Inflammatory Arthritis; Intercrines; Intracellular Communication and Signaling; Label; Laboratories; Lead; Location; Lucentis; Lung; Macular degeneration; Macular degenerative disease; Maculopathy, Age-Related; Malignant Neoplasms; Malignant Tumor; Mediating; Medication; Membrane; MoAb VEGF; Molecular; Monoclonal Antibody Anti-VEGF; Morphogenesis; Neovascularization, Pathological; P160ROCK; Pathologic Neovascularization; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Psoriasis; RMSN; ROCK1; ROCK1 gene; Randomized; Receptor Protein; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Regulation; Remission; Reporting; Respiratory System, Lung; Retinal; Retinal Degeneration; Rheumatoid Arthritis; RhuMAb VEGF; Role; SIS cytokines; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subcellular Process; Targetings, Gene; Therapeutic; Tissue Growth; Tissues; Treatment Side Effects; VEGFs; Validation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vascularization; Vasculotropin; Vegf; angiogenesis; base; bevacizumab; biological signal transduction; capillary; cell adhesion protein; chemoattractant cytokine; chemokine; clinical investigation; cultured cell line; cytokine; design; designing; diabetic; disease/disorder; drug use; drug/agent; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; intracellular skeleton; malignancy; member; membrane structure; metastatic colorectal; migration; neoplasm/cancer; new therapeutic target; novel; ontogeny; pathway; psoriasiform; psoriatic; psoriatiform; public health relevance; pulmonary; randomisation; randomization; randomly assigned; ranibizumab; receptor; research study; retina degeneration; retinal degenerative; rhuFab V2; rhuMabVEGF; senile macular disease; side effect; social role; therapeutic target; therapy adverse effect; transcription factor; treatment adverse effect; tumor; tumor growth; vascular",The role of VEGF-stimulated Rhoa/ROCK2 signaling in blood vessel formation.," Project Narrative Diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and more than 70 other known conditions are all characterized by excessive or insufficient blood vessel growth. The aims proposed in this project, which are designed to elucidate the role of a protein called ROCK2 in blood vessel formation, will provide a better understanding of the deregulation of cellular signaling in abnormal blood vessel formation. The findings from this project will lay a foundation for the development of more efficiently targeted therapeutics for these diseases.",98931,CDD,Cardiovascular Differentiation and Development Study Section,,1,206302,
7881342,R15,NS,1,,02/01/2010,01/31/2013,PA-06-042,1R15NS070268-01,,NINDS:203100;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HIGHLAND HEIGHTS,UNITED STATES,BIOLOGY,04,072879760,US,KY,41099,NORTHERN KENTUCKY UNIVERSITY,"SCHULTHEIS, PATRICK JOHN;",6949336;,1R15NS070268,02/01/2010,01/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; ATP phosphohydrolase; ATPase; Ablation; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Age; Aminalon; Aminalone; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Anxiety; Assay; Atrophic; Atrophy; Autophagocytosis; Basal Ganglia; Basal Nuclei; Behavior; Behavioral; Behavioral Assay; Bioassay; Biologic Assays; Biological Assay; Bradykinesia; Brain; Butanoic acid, 4-amino-; C elegans; C.elegans; Caenorhabditis elegans; Cell Count; Cell Function; Cell Number; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cellular Function; Cellular Inclusions; Cellular Physiology; Cellular Process; Chronic; Clinical; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Corpus Striatum; Corpus striatum structure; DA Neuron; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Degradation Pathway; Degradative Pathway; Depression; Development; Disease; Disorder; Disturbance in cognition; Dopamine; Dopamine neuron; Dysfunction; Encephalon; Encephalons; Environmental Factor; Environmental Risk Factor; Equilibrium; Exhibits; Exons; Functional disorder; GABA; Gait; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glia; Glial Cells; Globus Pallidus; Glutamate Carboxy-Lyase; Glutamate Decarboxylase; Glutamic Acid Decarboxylase; Hereditary; Homolog; Homologous Gene; Homologue; Human; Human, General; Hydroxytyramine; IP injection; Idiopathic Parkinson Disease; Impaired cognition; Inclusion Bodies; Inherited; Injections, Intraperitoneal; Intraperitoneal Injections; Knockout Mice; Kolliker's reticulum; Kufor-Rakeb syndrome gene; L-Glutamate-1-carboxy-lyase; L-Tyrosine,tetrahydrobiopterin[{..}]oxygen oxidoreductase (3-hydroxylating); Lead; Learning; Lewy Bodies; Lewy Body Parkinson Disease; Link; MRI Scans; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manganese; Measurement; Mediating; Memory; Mental Depression; Mice; Mice, Knock-out; Mice, Knockout; Mn element; MnCl2; Motor; Movement; Murine; Mus; Muscle Rigidity; Mutation; NAC precursor; Nematoda; Nematodes; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Non-neuronal cell; Null Mouse; Ortholog; Orthologous Gene; Oxidative Stress; PARK1 protein; PARK4 protein; PARK9; PARK9 gene; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson disease 9 gene; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Pathogenesis; Patients; Pb element; Phenotype; Phosphorylation Site; Physiopathology; Play; Predisposition; Primary Parkinsonism; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Rat; Rattus; Relative; Relative (related person); Research; Rigidity; Rigidity, Muscular; Rodent; Rodentia; Rodentias; Role; SNCA; SNCA protein; Saline; Saline Solution; Scans, MRI; Staining method; Stainings; Stains; Striate Body; Striatum; Subcellular Process; Substantia Nigra; Substantia nigra structure; Substrate Specificity; Susceptibility; Symptoms; Syndrome; Testing; Toxic effect; Toxicities; Tremor; Tyrosine 3-Monooxygenase; Tyrosine Hydroxylase; Yeasts; alpha synuclein; alphaSP22; autophagy; balance; balance function; behavior test; behavioral test; body movement; brain tissue; cognitive dysfunction; cognitive loss; cognitively impaired; cresyl violet; design; designing; disease/disorder; dopaminergic neuron; environmental risk; enzyme activity; exposed human population; gamma-Aminobutyric Acid; gene product; genome mutation; heavy metal Pb; heavy metal lead; human exposure; improved; insight; lysosomal proteins; manganese chloride; manganese chloride (MnCl2); manganese dichloride; manganous chloride; model organism; morris water maze; morris watermaze; nerve cement; neural degeneration; neurodegeneration; neurodegenerative illness; neuron toxicity; neuronal; neuronal degeneration; neuronal toxicity; neurotoxic; neurotoxicity; nigrostriatal pathway; non A-beta component of AD amyloid; non A4 component of amyloid precursor; non-human primate; nonhuman primate; novel; pallidum; pathophysiology; protein degradation; public health relevance; roundworm; social role; striatal",Behavioral and Neuroanatomical Characterization of a Novel Genetic Animal Model o," Project Narrative: Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have created a mouse animal model to research a rare, inherited form of this disease called Kufor- Rakeb syndrome. Our findings could lead to new insights into the causes of PD and its treatment.",70268,CDIN,Cell Death in Neurodegeneration Study Section,,1,203100,
7774048,R21,AI,1,,02/01/2010,11/30/2011,PA-06-181,1R21AI085250-01,,NIAID:247500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"ISBERG, RALPH R;",2071591;,1R21AI085250,02/01/2010,11/30/2012,"Actins; Address; Assay; Bacteria; Bacterial Gene Proteins; Bacterial Proteins; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Cell Communication; Cell Components; Cell Function; Cell Interaction; Cell Isolation; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Structure; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Structures; Chaperone; Communicable Diseases; Complex; Cultured Cells; Cytoskeletal System; Cytoskeleton; Data; Defect; Deposit; Deposition; Detection; Development; Diarrhea; Disease; Disease Progression; Disorder; Ensure; Event; FRET; Family member; Fluorescence Resonance Energy Transfer; Future; GAP Proteins; GTPase-Activating Proteins; Gene Products, Bacterial; Gene Products, RNA; Genes; Genome, Human; Goals; Gram-Negative Bacteria; History; Human; Human Genome; Human, General; Image; Image Analyses; Image Analysis; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intervention; Intervention Strategies; Lactamase; Lead; Lentivirinae; Lentivirus; Libraries; Longitudinal Studies; Man (Taxonomy); Man, Modern; Measures; Molecular Chaperones; Motility; Motility, Cellular; Movement; Nature; Outcome; P. pseudotuberculosis; Participant; Pasteurella pseudotuberculosis; Pb element; Plague; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein translocation; Proteins; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; ROC Analysis; Recording of previous events; Ribonucleic Acid; Scheme; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Site; Sorting - Cell Movement; Staging; Subcellular Process; Subfamily lentivirinae; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Therapeutic Intervention; Transmembrane Protein Transport; Type III Secretion System; Type III Secretion System Pathway; Virulent; Virus-Lenti; Work; Y. pseudotuberculosis; Yersinia; Yersinia pestis disease; Yersinia pseudotuberculosis; base; body movement; cell motility; cell sorting; d-Numb; disease/disorder; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase activating protein; heavy metal Pb; heavy metal lead; image evaluation; imaging; innovate; innovation; innovative; interest; intervention therapy; interventional strategy; intracellular skeleton; long-term study; novel; numb protein; pathogen; pathogenic bacteria; protein function; protein protein interaction; public health relevance; reconstruction; research study; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; screening; screenings; sensor; shRNA; short hairpin RNA; small hairpin RNA; sorting; success; trafficking",Host Protein Modulation of Type III Secretion," Specialized protein translocation systems encoded by pathogenic bacteria are critical for establishing colonization and causing disease within human hosts by facilitating the movement of bacterial proteins that are toxic for host cells. Evidence exists that the host cell is somehow collaborating with the pathogen to allow itself to be intoxicated, but unfortunately very little is known regarding how the host becomes an unwitting participant in the process. By taking advantage of assays recently developed for identifying cells misregulated by the bacterial protein, schemes are proposed to uncover proteins that collaborate with the pathogen. The data obtained are intended to work toward the long-term goal of finding host proteins that escort a broad swath of pathogen proteins, providing potential sites for chemotherapeutic intervention.",85250,ZRG1,Special Emphasis Panel,,1,247500,
7787149,R21,AI,1,,01/16/2010,12/31/2010,AI-08-055,1R21AI085548-01,,NIAID:190350;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RENO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,146515460,US,NV,89557,UNIVERSITY OF NEVADA RENO,"AUCOIN, DAVID P;KOZEL, THOMAS R (contact);",1868240 (contact);6956339;,1R21AI085548,01/16/2010,12/31/2011,"2-dimensional; ATGN; Animal Model; Animal Models and Related Studies; Antibodies; Antifungal Therapy; Antigen Targeting; Antigens; Antigens, Fungal; Aspergillosis; Aspergillus; Aspergillus fumigatus; BALB/c; Bacteremia; Blood; Blood Serum; Body Fluids; Body Tissues; Cavia; Cells; Detection; Development; Diagnosis; Diagnosis, Immunological; Diagnostic; Distant; Early Diagnosis; Employee, Untrained; Evaluation; Fungal Antigens; Fungal Gene Proteins; Fungal Proteins; Gel; Gene Products, Fungal; Glycans; Goals; Guinea Pigs; Hand; Hyphae; Immune; Immunoassay; Immunoblotting; Immunodiagnoses; Immunodiagnosis; Immunodiagnostics; Immunologic Diagnosis; Immunological Diagnosis; Inbred BALB C Mice; Infection; Left; Lung; Mammals, Guinea Pigs; Mammals, Mice; Melioidosis; Mice; Mice, Inbred BALB C; Moab, Clinical Treatment; Modeling; Monoclonal Antibodies; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouse, BALB C; Murine; Mus; Organism; Patients; Personnel, Untrained; Phase; Polysaccharides; Preparation; Process; Proteins; Relapsing Fever; Reproduction spores; Respiratory System, Lung; Reticuloendothelial System, Blood; Route; Sampling; Serum; Site; Specificity; Spores; Technology; Tissues; Treatment Failure; Tularemia; Untrained Personnel; Urinary System, Urine; Urine; WHBLOOD; Whole Blood; anti-microbial; antimicrobial; bacteraemia; base; communicable disease diagnosis; cost; early detection; experience; fungus; fungus protein; gene product; immunogen; improved; in vivo; infectious disease diagnosis; living system; microbial antigen; microorganism antigen; model organism; new approaches; novel approaches; novel strategies; novel strategy; pulmonary; treatment of fungal infectious disease; two-dimensional; worker, untrained",Target discovery and immunoassay for diagnosis of invasive aspergillosis, Immunoassay for detection of Aspergillus antigens in blood or urine has great promise for early diagnosis of invasive aspergillosis (IA). The project goals are: i) identification of fungal proteins that are shed into serum or urine during IA and ii) development and evaluation of immunoassays for detection of these target proteins.,85548,ZAI1,Special Emphasis Panel,,1,190350,
7839564,R21,AI,1,,02/01/2010,01/31/2011,PA-09-119,1R21AI087383-01,,NIAID:153286;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"SHAW, GEORGE M;",1973933;,1R21AI087383,02/01/2010,01/31/2012,"AIDS Vaccines; AIDS Virus; Address; Antibodies; Area; Award; Biological; Blood Plasma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells; Cells, CD4; Cessation of life; Clinical; Cloning; Cloning, Molecular; DNA; Death; Deoxyribonucleic Acid; Development; Dose; Evolution; FLR; Failure (biologic function); Genome; HIV vaccine; HIV-1; HIV-1 vaccine; HIV-I; HIV/AIDS Vaccines; HIV1; HIV1 vaccine; Human; Human immunodeficiency virus 1; Human, General; Immune response; Immunodeficiency Virus Type 1, Human; In Vitro; Infection; Kinetic; Kinetics; Knowledge; Laboratories; Lead; Length; Life; Light; Lymphocyte Depletion; Macaca; Macaca mulatta; Macaque; Man (Taxonomy); Man, Modern; Methods; Modeling; Molecular; Molecular Cloning; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Pathogenesis; Pathogenicity; Pathway interactions; Pb element; Phase; Phased Innovation Awards; Phenotype; Photoradiation; Plasma; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; R21/R33 Mechanism; R21/R33 Program; RNA, Viral; Reagent; Research Priority; Reticuloendothelial System, Serum, Plasma; Rhesus; Rhesus Macaque; Rhesus Monkey; SEQ-AN; SIV; Sequence Analyses; Sequence Analysis; Serum, Plasma; Sexual Transmission; Simian Immunodeficiency Viruses; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Time; Transmission; Transmission, Sexual; Tropism; United States National Institutes of Health; Vaccine Design; Vaccine Research; Vaccines; Viral Diseases; Viral Genome; Viremia; Virus; Virus Diseases; Viruses, General; base; efficacy trial; failure; heavy metal Pb; heavy metal lead; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunoresponse; in vivo; innovate; innovation; innovative; new approaches; new technology; new vaccines; next generation vaccines; non-human primate; nonhuman primate; novel; novel approaches; novel strategies; novel strategy; novel vaccines; pandemic; pandemic disease; pathway; programs; public health relevance; thymus derived lymphocyte; transmission process; viraemia; viral RNA; viral infection; viral sepsis; virus RNA; virus infection; virusemia","Cloning, characterization and in vivo testing of mucosally transmitted SIV", Project Narrative One of the most important knowledge gaps in HIV/AIDS vaccine research relates to the molecular properties of HIV-1 that are responsible for sexual transmission and the initial virus-host cell interactions that lead to productive viral infection. The present proposal takes advantage of our laboratory's recent discovery of a novel method for identifying transmitted HIV-1 viruses and applies this new technology to the discovery and characterization of transmitted simian immunodeficiency viruses (SIV). These results will shed new light on the molecular basis of mucosal transmission by SIV in the rhesus macaque model and promise to aide in the identification of new vaccine targets and strategies.,87383,AIP,AIDS Immunology and Pathogenesis Study Section,,1,153286,
7871109,R21,AI,1,,02/01/2010,01/31/2011,PA-09-164,1R21AI088038-01,,NIAID:185625;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,VETERINARY SCIENCES,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HARMS, JEROME SCOTT;",9833974;,1R21AI088038,02/01/2010,01/31/2012,"Adaptor Protein; Adaptor Signaling Protein; Address; Animals, Domestic; Architecture; Assay; B. melitensis; B.melitensis; Bacteria; Bioassay; Biologic Assays; Biological Assay; Blotting, Western; Brucella; Brucella melitensis; Brucella melitensis bacterium; Brucellosis; Cannot achieve a pregnancy; Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Cellular Matrix; Chronic; Communicable Diseases; Culture Media; Cytokine Suppression; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Cytoskeletal System; Cytoskeleton; Data; Difficulty conceiving; Domestic Animals; ELISA; Engineering / Architecture; Environment; Enzyme-Linked Immunosorbent Assay; Event; GTP Phosphohydrolases; GTPases; Goals; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Human; Human, General; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Incubated; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infertility; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Killings; Kinetic; Kinetics; L-Leucine; Leucine; Leucine, L-Isomer; Life Style; Lifestyle; Link; Malta Fever; Mammalia; Mammalian Cell; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Membrane; Micro-tubule; Microtubules; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Natural Immunity; Nocodazole; Oncodazole; Pathogenesis; Penetration; Peptides; Permeability; Phagocytosis; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Plasma Membrane; Play; Property; Property, LOINC Axis 2; Proteins; PtdIns; Receptor Protein; Reporter; Role; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Specificity; System; System, LOINC Axis 4; TIL4; TLR protein; TLR2; TLR2 gene; TLR4; TLR4 gene; TOLL; Testing; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Tubulin; Two Hybrid; Undulant Fever; Unspecified Abortion; Vacuole; Virulence; Virulent; Western Blotting; Western Blottings; Western Immunoblotting; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; abortion; base; biological signal transduction; computerized data processing; cytokine; data processing; domesticated animal; experiment; experimental research; experimental study; extracellular; gene product; growth media; guanosinetriphosphatase; hToll; host response; immunoresponse; infertile; intracellular skeleton; macrophage; membrane structure; pathogen; plasmalemma; polymerization; protein blotting; protein function; public health relevance; receptor; research study; response; screening; screenings; signal processing; social role; trait; unable to bear children; yeast two hybrid system",TIR domain containing protein from Brucella melitensis," Project Narrative Our proposal will determine the effect of a TIR domain containing protein of Brucella melitensis that suppresses NFkB signaling as well as hijack the signaling pathway of Toll-Like Receptor proteins that possess an extracellular leucine-rich domain and a cytoplasmic domain referred to as Toll/IL-1R domain or TIR domain. Brucella spp. encode a TIR domain-containing protein (27 kDa) that can suppress the innate immune responses allowing the bacterium to successfully establish an intracellular niche. We are confident of achieving our project goals based on preliminary data that demonstrate our ability in each specific aim. We will first explore the detailed mechanism of TcpB mediated NF-¨B suppression. This aim will identify the various host proteins that TcpB engages. Second, we will analyze the secretion of TcpB by Brucella melitensis and membrane penetration of TcpB. This aim will link the mechanism of TcpB transport from the bacterium to the internal environment of the cell. Third, we will analyze the effect of TcpB on tubulin polymerization and TcpB mediated activation of small GTPases. This aim will identify how TcpB disrupts cell architecture and potentially alters additional host signaling processes. We are confident of achieving these goals based on preliminary data that demonstrate our ability in each specific aim. The Problem: B. melitensis, a Gram-negative facultative intracellular bacterium, induces chronic infectious disease in humans and domestic animals. While an initial framework of several B. melitensis virulence traits has been documented, little is known about the mechanisms used by Brucella virulence associated proteins that permit an intracellular lifestyle. Now, we have preliminary data supporting a role for the Brucella protein TcpB to disrupt the very early steps of host cell response to this pathogen by disrupting the initial signaling events of innate immunity. Thus, pathogenic intracellular Brucella utilize a number of mechanisms to evade macrophage killing. Unfortunately, little is known regarding how any of these Brucella proteins function mechanistically to hijack host intracellular defenses. The Product: Our Preliminary Studies have identified a B. melitensis TIR domain containing protein, termed TcpB, that possesses the ability to alter signaling events in host cells and disrupt innate immune mechanisms. Critical information gained from these specific aims will begin to bridge the gap between what we know about B. melitensis virulence and how virulence is regulated.",88038,ZRG1,Special Emphasis Panel,,1,185625,
7874019,R21,AI,1,,02/01/2010,01/31/2011,PA-09-164,1R21AI088070-01,,NIAID:218160;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MANHATTAN,UNITED STATES,BIOLOGY,02,929773554,US,KS,665061103,KANSAS STATE UNIVERSITY,"CHAPES, STEPHEN K (contact);VON OHLEN, TONIA L;",6065413;8263672 (contact);,1R21AI088070,02/01/2010,01/31/2012,"21+ years old; Address; Adult; Affect; Amblyomma; Anaplasma phagocytophila; Anaplasma phagocytophilum; Anthrax; Anthrax disease; Arthropoda; Arthropods; B. anthracis; Bacillus anthracis; Bacteria; Biochemical; Biochemical Pathway; C. burnetii; Categories; Cells; Communicable Diseases; Communicable Diseases, Emerging; Cowdria; Coxiella burnetii; Cytoecetes phagocytophila; Data; Disease; Disorder; Double-Stranded RNA; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drosophila; Drosophila genus; Drosophila melanogaster; Drugs; Ehrlichia; Ehrlichia chaffeensis; Ehrlichia equi; Ehrlichia phagocytophila; Ehrlichiosis; Emerging Communicable Diseases; Flies; Fruit Fly, Drosophila; Gene Down-Regulation; Gene Expression; Gene Inactivation; Gene Silencing; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; HGE Agent; Head; Hemocytes; Human; Human, Adult; Human, General; Immunologist; In Vitro; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Diseases, Emerging; Infectious Disorder; Invertebrata; Invertebrates; Invertebrates, General; Ixodida; Lead; Libraries; Man (Taxonomy); Man, Modern; Medication; Metabolic Networks; Modeling; Mutation; Organism; Outcome; Pasteurella pestis; Pathogenesis; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Plague; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Q Fever; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Double-Stranded; RNAi; Rickettsia Infections; Rickettsia rickettsii; Rickettsial Infectious Disease; Rickettsial Infectious Disorder; Rickettsiales disease; Rickettsiosis; Rocky Mountain Spotted Fever; Scientist; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Sorting - Cell Movement; System; System, LOINC Axis 4; Testing; Ticks; Tissue Growth; Transcription Repression; Transcriptional Repression; Typhus, Sao Paulo; United States; Vector-borne disease; Vector-borne infectious disease; Vector-transmitted disease; Vector-transmitted infectious disease; Vertebrate Animals; Vertebrates; Work; Y. pestis; Y.pestis; Yersinia pestis; Yersinia pestis disease; adult human (21+); anthracis; disease/disorder; drug/agent; dsRNA; experiment; experimental research; experimental study; fly; fruit fly; fundamental research; gene repression; genome mutation; heavy metal Pb; heavy metal lead; human granulocytic ehrlichiosis; in vivo; innovate; innovation; innovative; intracellular parasitism; living system; macrophage; meetings; multidisciplinary; mutant; ontogeny; pathogen; pathway; prevent; preventing; public health relevance; research study; rickettsial disease; screening; screenings; sorting; vertebrata",Definition of host genes required for intracellular pathogen growth, Project Relevance This is a biomedically related project that addresses which host genes are necessary for the successful replication of an intracellular bacteria that is a human category C pathogen.,88070,VB,Vector Biology Study Section,,1,218160,
7789289,R21,AR,1,,02/01/2010,01/31/2011,PA-06-542,1R21AR057159-01A1,,NIAMS:163571;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,MADISON,UNITED STATES,MISCELLANEOUS,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KOLTYN, KELLI F;",6100052;,1R21AR057159,02/01/2010,01/31/2012,"Absence of pain sensation; Absence of sensibility to pain; Age; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animal Experimental Use; Animal Experimentation; Animal Research; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Arthritis; Blood; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; Cannabinoids, Endogenous; Causality; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Clinical; Colitis, Mucous; Colon, Irritable; Consensus; Country; Cranial Pain; Crossover Design; Designs, Cross-Over; Diffuse Myofascial Pain Syndrome; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Du Pont Brand of Naltrexone Hydrochloride; Emotional well being; Endocannabinoids; Endogenous Opiates; Etiology; Exercise; Exercise, Physical; Feels no pain; Feels well; Female; Fibromyalgia; Fibromyositis-Fibromyalgia Syndrome; Fibrositis; Head Pain; Headache; Health; Health Care Costs; Health Costs; Healthcare Costs; Human; Human, General; In element; Indium; Individual; Institute of Medicine; Institute of Medicine (U.S.); International; Investigators; Irritable Bowel Syndrome; Knowledge; Lamepro Brand of Naltrexone Hydrochloride; MPD syndrome; Man (Taxonomy); Man, Modern; Mediating; Mediation; Mental well-being; Method LOINC Axis 6; Methodology; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; NAS/IOM; NIH; Nalorex; Naltrexone; Narcotic Antagonists; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Nemexin; Neurochemistry; No sensitivity to pain; Normal mental condition; Normal mental state; Normal psyche; Operating System; Opiate Antagonist; Opioid; Opioid Antagonists; Orphan Brand of Naltrexone Hydrochloride; PBO; Pain; Pain Control; Pain Therapy; Pain management; Painful; Participant; Perception; Placebo Control; Placebos; Pressure; Pressure- physical agent; Prevalence; Prevention; Productivity; Programs (PT); Programs [Publication Type]; Protected Sex; Psychological Well Being; Randomized; ReVia; Recruitment Activity; Reporting; Research; Research Personnel; Researchers; Responsible Sex; Responsible sexual behavior; Reticuloendothelial System, Blood; Rheumatism, Muscular; Safe Sex; Schering-Plough Brand of Naltrexone Hydrochloride; Science of neurochemistry; Sense of well-being; Sex Characteristics; Sex Differences; Sham Treatment; Stimulus; Syndrome; System; System, LOINC Axis 4; TMJ Diseases; TMJ Disorders; TMJD; Temporo-mandibular joint disorder; Temporomandibular Disorders; Temporomandibular Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular joint disorder; Terminology; Testing; Therapeutic; United Drug Brand of Naltrexone Hydrochloride; United States National Institutes of Health; Well in self; Woman; analgesia; arthritic; attenuation; base; chronic pain; chronic painful condition; cost; disease causation; disease etiology; disease/disorder etiology; disorder etiology; endogenous opioid; fibromyalgia syndrome; gender difference; male; men; men's; myofascial pain dysfunction syndrome; neurochemistry; new approaches; novel approaches; novel strategies; novel strategy; preclinical study; pressure; programs; psychological wellness; public health relevance; randomisation; randomization; randomly assigned; recruit; response; self wellness; sex; sexual dimorphism (noncellular); sham therapy; social; spastic colon",Attenuation of Pain in Men and Women: Mechanisms of Exercise-Induced Analgesia," The perception of pain is modulated by multiple endogenous analgesic systems, and there is evidence that these systems operate differently in men and women. Given the substantially greater prevalence of many clinical pain conditions in women vs men, it is essential to gain a better understanding of sex differences in endogenous pain inhibitory mechanisms which will ultimately permit the tailoring of better treatments to enhance pain control in both men and women.",57159,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",A1,1,163571,
7788286,R21,AR,1,,01/15/2010,12/31/2010,PA-06-181,1R21AR057243-01A1,,NIAMS:223425;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"BROADUS, ARTHUR EASTWOOD;",1902637;,1R21AR057243,01/15/2010,12/31/2011,"Anaplastic; Arthritis; Arthritis, Degenerative; Articulation; Bone Development; Cartilage; Cartilage, Articular; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Chondrocytes; Degenerative polyarthritis; Dysfunction; Embryo; Embryonic; Erinaceidae; Functional disorder; Generalized Growth; Genes; Growth; Gx Protein; Hedgehogs; Hypercalcemic Hormone of Malignancy; Intracellular Communication and Signaling; Joints; Load-Bearing; Loadbearing; Maintenance; Maintenances; Mammals, Mice; Mechanics; Mice; Modeling; Molecular; Murine; Mus; Osteoarthritis; Osteoarthrosis; PTH Like Tumor Factor; PTH-Like Protein; PTH-Related Peptide; PTHrP; Parathyroid Hormone Like Tumor Factor; Parathyroid Hormone-Like Hormone; Parathyroid Hormone-Like Protein; Parathyroid Hormone-Related Peptide; Pathway interactions; Peptide Signal Sequences; Physiopathology; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protocol; Protocols documentation; Recombinant Parathyroid Hormone-Related Protein; Role; SMO; SMO protein, human; SMOH; SMOH protein, human; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Smoothened; Smoothened Homolog; Structure of articular cartilage; Testing; Tissue Growth; Tumor Hypercalcemic Factor; Undifferentiated; Weight-Bearing; Weight-Bearing state; Weightbearing; Work; arthritic; articular cartilage; biological signal transduction; combinatorial; degenerative joint disease; design; designing; disability; human SMO protein; hypertrophic arthritis; insight; mineralization; ontogeny; parathyroid hormone-related protein; pathophysiology; pathway; prevent; preventing; programs; protein signal sequence; public health relevance; smoothened homolog (Drosophila), human; social role",Ihh and PTHrP Regulate Articular Chondrocyte Maintenance," Project Narrative  The chondrocytes that make up articular cartilage must remain in their native, undifferentiated state in order for this cartilage to carry out its normal functions, which include lubricating the joints and cushioning load in weight-bearing joints. When chondrocytes differentiate, they begin to mineralize and degenerate, and these are hallmarks of osteoarthritis, the most common form of arthritis, and a leading cause of disability worldwide. We describe here two regulatory molecules that together seem to regulate articular chondrocyte differentiation and describe models that may provide insight into the cause of osteoarthritis at a cellular and molecular level.",57243,SBSR,Skeletal Biology Structure and Regeneration Study Section,A1,1,223425,
7768143,R21,AR,1,,03/01/2010,02/28/2011,PA-06-181,1R21AR057794-01,,NIAMS:245700;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SEATTLE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"YABLONKA-REUVENI, ZIPORA ;",1882037;,1R21AR057794,03/01/2010,02/29/2012,"21+ years old; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Adult; Adventitial Cell; Aging; Animals; Area; Asphyxia; Behavioral; Biopsy; Blood Circulation; Bloodstream; Blotting, Western; CD31; Cancers; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Therapy; Cells; Cessation of life; Circulation; Clinical; Clinical Research; Clinical Study; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cranin; Death; Development; Diabetes Mellitus; Disease; Disorder; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Dystroglycan; Dystroglycans; Dystrophin; Effectiveness; Ellis-van Creveld (EvC) syndrome; Endothelium; Engraftment; Exploratory/Developmental Grant; Extremities; Femoral Artery; Future; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Goals; Guidelines; Hereditary Disease; Human, Adult; Immunologic Deficiency Syndrome, Acquired; Inbred mdx Mice; Injection of therapeutic agent; Injections; Intra-Arterial Injections; Intra-Arterial Route of Drug Administration; Intraarterial Injections; Intraarterial Route of Drug Administration; Intramuscular; Investigation; Knowledge; Lead; Life; Limb structure; Limbs; Lung; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Inbred mdx; Modeling; Molecular Disease; Mother Cells; Mouse, mdx; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Embryonic; Muscle Cells, Mature; Muscle Cells, Precursor; Muscle Fibers; Muscle Tissue; Muscle satellite cell; Muscle, Skeletal; Muscle, Voluntary; Muscular Dystrophies; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Mutation; Myoblasts; Myocytes; Myodystrophica; Myodystrophy; Myotubes; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Non-Trunk; Organ; Outcome; PECAM1; PECAM1 gene; Patients; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Progenitor Cells; Progressive Muscular Dystrophy, Duchenne Type; Proliferating; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Pseudohypertrophic Muscular Dystrophy, Childhood; R01 Mechanism; R01 Program; R21 Mechanism; R21 Program; RPG; Reporter; Reporting; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Respiratory Muscles; Respiratory System, Lung; Retinal; Rhabdomyocyte; Risk; Rouget Cells; Sarcolemma; Senescence; Sepsis; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Source; Staging; Stem cells; Striated Muscle Tissue; Striated Muscles; Structure of femoral artery; Suffocation; System; System, LOINC Axis 4; Techniques; Therapy, Cell; United States National Institutes of Health; Venous; Ventilatory Muscles; Wasting Disease; Wasting Syndrome; Western Blotting; Western Blottings; Western Immunoblotting; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; adult human (21+); asphyxiation; base; benign X-linked recessive muscular dystrophy; bloodstream infection; cell sorting; cell-based therapy; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; clinical practice; combat; congenital muscular dystrophy; diabetes; disease/disorder; femoral artery; genetic disorder; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; in vivo; insight; malignancy; mild X-linked recessive muscular dystrophy; muscle form; muscle stem cell; neoplasm/cancer; novel; progressive muscular dystrophy of childhood; protein blotting; protein complex; protein expression; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; public health relevance; pulmonary; regenerative; repair; repaired; satellite cell; senescent; skeletal; wasting",Intra-arterial delivery of skeletal muscle stem cells," PROJECT NARRATIVE Muscle wasting is associated with muscular dystrophies and causes generalized weakness and debilitation and in severe cases, leads to early lethality. Muscle wasting is also associated with aging and is a hallmark of a number of diseases including cancer and diabetes. The proposed study will evaluate whether systemically delivered donor cells can reach target muscles and contribute to muscle repair and increased muscle mass. The anticipated results will provide important insights for developing cell-based therapies to combat muscle wasting disorders.",57794,ZRG1,Special Emphasis Panel,,1,245700,
7772801,R21,AR,1,,03/01/2010,12/31/2010,PA-06-181,1R21AR057930-01,,NIAMS:258480;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,MANHASSET,UNITED STATES,,05,110565913,US,NY,11030,FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH,"DAVIDSON, ANNE ;",1973352;,1R21AR057930,03/01/2010,12/31/2011,"Adhesion Molecule; Adhesions; Affect; Alleles; Allelomorphs; Amino Acid Substitution; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Biopsy; Blood leukocyte; Blood monocyte; CD11b; CR3A; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell surface; CellLine; Cellular Migration; Characteristics; Coagulants; Code; Coding System; DNA; Deoxyribonucleic Acid; Disease; Disorder; Enrollment; Ethnic group; Event; Explosion; Extracellular Matrix, Integrins; GWAS; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Haplotypes; Human; Human, General; ITGAM; ITGAM gene; Incidence; Individual; Inflammatory; Integrins; Intracellular Communication and Signaling; Kidney; Laboratories; Leukocytes; Ligand Binding; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; MAC-1; MAC1A; MO1A; Man (Taxonomy); Man, Modern; Marrow leukocyte; Marrow monocyte; Measures; Modeling; Motility; Motility, Cellular; Nephritis; Phagocytosis; Phenotype; Phosphorylation; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Production; Protein Phosphorylation; Protocol; Protocols documentation; Registries; Research; Research Resources; Resources; Reticuloendothelial System, Leukocytes; Risk; SLE; SLE - Lupus Erythematosus, Systemic; Severities; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Solvents; Susceptibility; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Testing; Time; Urinary System, Kidney; Variant; Variation; Variation (Genetics); White Blood Cells; White Cell; allelic variant; association test; autoimmune disorder; base; biological signal transduction; cell adhesion protein; cell motility; clinical remission; cultured cell line; cytokine; disease severity; disease/disorder; disseminated lupus erythematosus; enroll; gain of function; genetic association; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; interest; mRNA Expression; macrophage; migration; monocyte; overexpression; particle; peripheral blood; polymorphism; public health relevance; renal; self recognition (immune); systemic lupus erythematosis; white blood cell; white blood corpuscle; whole genome association studies; whole genome association study; willingness",Functional significance of an ITGAM polymorphism in SLE," The goal of this proposal is to determine the functional significance of the R77H coding region polymorphism in the ITGAM gene that is associated with human SLE. ITGAM encodes the alpha chain of the CD11b adhesion molecule expressed on leukocytes and monocytes. The approach will be to use peripheral blood normal individuals homozygous for the two allelic forms of ITGAM to analyze the expression of CD11b and the function of monocytes with respect to adhesion, migration and expression of pro-inflammatory molecules.",57930,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,1,258480,
7787632,R21,CA,1,,01/25/2010,12/31/2010,PA-08-165,1R21CA124942-01A2,,NCI:186377;,2010,NATIONAL CANCER INSTITUTE,,MINNEAPOLIS,UNITED STATES,NONE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MORRIS, REBECCA ;",1885286;,1R21CA124942,01/25/2010,12/31/2011,"Actinic Rays; Address; Annexins; Antibodies; Apoptosis; Apoptosis Pathway; Apoptotic; Benign; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bone Marrow Stem Cell; Bone Marrow Transplant; Bone Marrow Transplantation; CD34; CD34 gene; Calcimedins; Cancer Induction; Cancer of the Fundus of the Stomach; Cancer of the Gastric Body; Cancer of the Gastric Cardia; Cancer of the Gastric Fundus; Cancer of the Gastric Pylorus; Cancer of the Pylorus of the Stomach; Cancers; Carcinoma; Cell Death; Cell Death, Programmed; Cells; Characteristics; Chronic; Clinic; Colony-Forming Units, Neoplastic; Coon's Technic; Coon's Technique; Cutaneous; Development; Diagnosis; Epidemiology; Epidermis; Epithelial; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Event; Exposure to; Female; Fluorescent Antibody Technic; Fluorescent Antibody Technique; Fluorescent Antinuclear Antibody Test; Gastric Cancer; Genes, p53; Grafting, Bone Marrow; HPCA1; Hair Follicle; Hair follicle structure; Hand; Harvest; Health; Human; Human, General; Immune; Immunofluorescence Technic; Immunofluorescence Technique; Investigation; Keratin; Killings; Label; Laboratories; Langerhans cell; Left; Lesion; Lipocortins; Malignant; Malignant - descriptor; Malignant Gastric Neoplasm; Malignant Gastric Tumor; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Malignant Tumor of the Stomach; Malignant neoplasm of stomach; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Marrow Transplantation; Melanoma and Non-Melanoma Skin Cancer; Methods; Mice; Mice, Transgenic; Modeling; Mother Cells; Murine; Mus; Neoplasms; P53; Papilloma; Pattern; Population; Progenitor Cells; R 38486; R38486; RU-38486; RU-486; RU38486; RU486; Recruitment Activity; Relative; Relative (related person); Reporting; Research; Reticuloendothelial System, Bone Marrow; Role; Science; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Skin Cancer, Non-Melanoma; Skin Carcinogenesis; Skin Carcinoma; Skin Neoplasms; Staging; Staining method; Stainings; Stains; Stem Cells, Neoplastic; Stem cells; Stomach; Stomach Cancer; Sun/Ultra-Violet Rays; Sunburn; Sunlight; T-Cells; T-Lymphocyte; TP53; TP53 gene; TRP53; Thinking; Thinking, function; Thymus-Dependent Lymphocytes; Tissues; Transgenic Mice; Transplantation; Tumor Protein p53 Gene; Tumor Stem Cells; Tumor of the Skin; Tumors; UV induced; UV radiation; UVB; UVB induced; UVB radiation; Ultraviolet B Radiation; Ultraviolet Rays; Y Chromosome; beta-D-Galactosidase; beta-D-Galactoside galactohydrolase; beta-Galactosidase; cancer diagnosis; carcinogenesis; cell preparation; epithelial carcinoma; experiment; experimental research; experimental study; fluorescent antibody; gastric; immunoreactivity; irradiation; keratinocyte; lac Z Protein; malignancy; malignant stomach neoplasm; mouse model; mutant; necrocytosis; neoplasia; neoplasm/cancer; neoplastic growth; nonmelanoma skin cancer; novel; public health relevance; recombinase; reconstitute; reconstitution; recruit; research study; skin lesion; social role; thymus derived lymphocyte; transplant; tumor; ultraviolet light; ultraviolet radiation",The Role of Bone Marrow Derived Cells in Skin Cancer," Project Narrative Chronic exposure of the skin to sunlight (UV light) is a major known cause of skin cancer. Although UV-induced skin cancers are widely believed to originate from epidermal or hair follicle stem cells, a recent report that stomach cancer can originate from the transformation of bone marrow derived cells challenges this dogma. The objective of the research proposed here is to determine the relative roles of Bone marrow derived cells and hair follicle stem cells and their progeny to developing skin tumors in the mouse UV model of skin cancer. The approach and results of this study are relevant to human health in that the will not only determine the respective contributions of bone marrow derived cells and hair follicle stem cells to skin cancer, they will also have the potential to change current thinking on the way that skin cancer is diagnosed and treated in the clinic.",124942,CE,Cancer Etiology Study Section,A2,1,186377,
7789926,R21,CA,1,,01/01/2010,12/31/2010,PA-06-270,1R21CA133701-01A2,,NCI:176168;,2010,NATIONAL CANCER INSTITUTE,,HUNTINGTON,UNITED STATES,PATHOLOGY,03,036156615,US,WV,25701,MARSHALL UNIVERSITY,"SOLLARS, VINCENT E;VALENTOVIC, MONICA A;WILKINSON IV, JOHN  (contact);",1943454 (contact);1959267;6672740;,1R21CA133701,01/01/2010,12/31/2011,"2-amino-4-mercaptobutyric acid; Absolute ethanol; Affect; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Apoptosis; Apoptosis Pathway; Area; Attenuated; Biology; Body Tissues; Butanoic acid, 4,4'-dithiobis(2-amino)-; C element; CAM 120/80; Cadherin-1; Cadherins; Cancer Biology; Cancer Genes; Cancer-Promoting Gene; Cancers; Carbon; Cell Death, Programmed; Cells; Cellular injury; Chemical Class, Alcohol; Chemicals; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chromosomal Instability; Chromosome Instability; Chronic; Cystathionine; DNA; DNA Methylation; Data; Deoxyribonucleic Acid; Development; Disease; Disorder; Dysplasia; E-Cadherin; EC 2; ETOH; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; EtOH drinking; Ethanol; Evaluation; Exposure to; Fatty Acid Ethyl Ester Synthase III, Myocardial; Fe element; Fibrosis; Folate Metabolism; Folic Acid Metabolosm; GST P1-1; GST-Pi; GST3; GSTP1; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Generations; Genes; Glutathione; Glutathione S-Transferase 3; Glutathione, Reduced; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Grain Alcohol; H ferritin; HGF/SF; HPLC; Hepatic; Hepatic Cancer; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; High Pressure Liquid Chromatography; Histologic; Histologically; Histones; Homocysteine; Homocysteine, L-Isomer; Homocystine; Human; Human, General; In Vitro; Individual; Intermediary Metabolism; Investigators; Iron; Iron Overload; L-Homocysteine, S-(2-amino-2-carboxyethyl)-, (R)-; L-Methionine; LINE Repeat Sequences; Lesion; Liver; Liver Cell Adhesion Molecules; Liver Cells; Long Interspersed DNA Sequence Elements; Long Interspersed Nucleotide Elements; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; METBL; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Metabolic Processes; Metabolism; Methionine; Methionine, L-Isomer; Methods; Methylation; Methylcarbinol; Mice; Modeling; Murine; Mus; NADH; Oncogenes; Pathway interactions; Phase; Population; Principal Investigator; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Methylation; Proteins; Reaction; Reduced Glutathione; Regulation; Research Personnel; Researchers; Risk; Risk Factors; SAH; Scatter Factor; Source; Stress; Subarachnoid Hemorrhage; Testing; Tet; Tetanus Helper Peptide; Tissues; Transferase; Transforming Genes; Transgenic Model; Uvomorulin; adduct; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; alpha1-microglobulin; angiogenesis; bikunin; bisulfite; body system, hepatic; cancer progression; cancer type; cell damage; cell injury; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; design; designing; disease/disorder; dyscrasia; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; folic acid metabolism; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; glutathione S-transferase pi; glutathione transferase P1-1; high risk; hydrogen sulfite; hydrosulfite; in vivo; inhibitor; inhibitor/antagonist; liver cancer; liver cell adhesion molecule; malignancy; malignant liver tumor; multidisciplinary; neoplasm progression; neoplasm/cancer; neoplastic; neoplastic progression; organ system, hepatic; oxidant stress; pathway; prevent; preventing; public health relevance; research study; tumor progression",Alcohol and Iron Derived Oxidant Stress Impact Epigenetic Regulation," PROJECT NARRATIVE: Alcohol drinking is known to place the drinker at increased risk for many types of cancer. Individuals that have iron overload disease are at much higher risk of developing liver cancer if they drink alcohol regularly. In addition, how cells handle iron can be influenced by alcohol, making iron an important factor in the development of alcohol associated cancer. Iron acts by causing an increase in a process that damages the cell, called oxidant stress. We think this process may affect a chemical that cells make that is responsible for regulating genes through modifying DNA. We propose to find out if this occurs in liver cells in mice. If this is the case, then we will have identified a mechanism by which iron and oxidant stress may help to drive the formation of cancer in alcohol drinkers. Discovering such a mechanism would give us targets that may help prevent alcohol associated cancer formation.",133701,CE,Cancer Etiology Study Section,A2,1,176168,
7788327,R21,CA,1,,01/18/2010,12/31/2010,PA-06-418,1R21CA135216-01A1,,NCI:222751;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,DERMATOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"RODECK, ULRICH  (contact);WILLIAMS, JOHN CHARLES;",1886198 (contact);8339566;,1R21CA135216,01/18/2010,12/31/2011,"ADCC; ATGN; Address; Adverse effects; Alimentary Canal; Animal Model; Animal Models and Related Studies; Anti-EGFR Monoclonal Antibody; Anti-Epidermal Growth Factor Receptor Monoclonal Antibody; Antibodies; Antibody -dependent cell cytotoxicity; Antibody Affinity; Antibody Fragments; Antibody-Dependent Cellular Cytotoxicity; Antigen Targeting; Antigenic Determinants; Antigens; Athymic Nude Mouse; Binding; Binding (Molecular Function); Binding Determinants; Biological Testing; C225; CLG4B; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Cytoxicity, Antibody-Dependent; Cell Line, Tumor; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cetuximab; Chimera Protein; Chimeric Proteins; Clinical; Clinical Management; Clinical Trials; Clinical Trials, Unspecified; Complex; Development; Diagnostic; Digestive Tract; Dimerization; Disease; Disorder; Dose-Limiting; Drug Precursors; EGFR; ERBB; ERBB Protein; ERBB1; ERBB2; ERBB2 gene; Engineering; Engineerings; Environment; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epitopes; Erbitux; Esteroproteases; External Domain; Extracellular Domain; Family member; Fusion Protein; Future; GELB; GI Tract; Gamma Globulin, 7S; Gastrointestinal Tract; Gastrointestinal tract structure; Generalized Growth; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Goals; Growth; HER -2; HER-2; HER1; HER2; HER2/neu; Her2/erbb2/neu Staining Method; Homing; Human; Human EGF Receptor 2 Gene; Human, General; IMC-C225; IgG; IgG1; Image; Immunoglobulin Fragments; Immunoglobulin G; In Vitro; Intracellular Communication and Signaling; Label; Ligand Binding; Link; MAb C225; MMP9; MMP9 gene; MOAB 225 Anti-EGFR (C225; Cetuximab); Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Masks; Medical Imaging, Positron Emission Tomography; Metallopeptidases; Metalloproteases; Metalloproteinases; Method LOINC Axis 6; Methodology; Mice; Mice, Athymic; Mice, Nude; MoAb C225; Moab, Clinical Treatment; Modification; Molecular; Molecular Interaction; Mono-S; MonoS; Monoclonal Antibodies; Monoclonal Antibody C225; Multiple Myeloma; Murine; Mus; Mutate; Myeloma, Plasma-Cell; Neoplasms; Normal Tissue; Normal tissue morphology; Nude Mice; PET; PET Scan; PET imaging; PETSCAN; PETT; Patients; Peptidases; Peptide Hydrolases; Point Mutation; Positron Emission Tomography Scan; Positron-Emission Tomography; Pro-Drugs; Prodrugs; Property; Property, LOINC Axis 2; Proteases; Protein Dimerization; Proteinases; Proteolytic Enzymes; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Reagent; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Recombinants; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin; Structure; Surface Plasmon Resonance; TKR1; Testing; Therapeutic; Tissue Growth; Toxic effect; Toxicities; Transforming Growth Factor alpha Receptor; Treatment Side Effects; Tumor Antigens; Tumor Cell; Tumor Cell Line; Tumor Tissue; Tumor-Associated Antigen; Tumors; Variant; Variation; Work; alimentary tract; antibody dependent cell mediated cytotoxicity; antibody engineering; anticancer therapy; antigen antibody affinity; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer therapy; cell growth; clinical investigation; design; designing; digestive canal; disease/disorder; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; extracellular; flexibility; gastrointestinal; her2/erbb2/neu; imaging; immunogen; in vitro testing; in vivo; inhibiting antibody; malignancy; metalloproteinase (general); model organism; myeloma; myelomatosis; neoplasia; neoplasm/cancer; neoplastic cell; neoplastic growth; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; peripheral blood; polypeptide; proto-oncogene protein c-erbB-1; public health relevance; receptor; reconstitute; reconstitution; research study; side effect; therapy adverse effect; tool; treatment adverse effect; trend; tumor; tumor growth; tumor xenograft; tumor-specific antigen",Monoclonal Antibody-based Prodrugs - Novel Tools for Cancer Therapy," NARRATIVE In recent years monoclonal antibodies (mAbs) have been used increasingly in the clinical management of certain forms of cancer and select other diseases. Most mAbs currently used in cancer therapy recognize tumor-associated antigens, which are also present on normal tissues. This circumstance leads to adverse side effects that limit the application and efficacy of these agents in patients. This proposal describes a novel concept to engineer antibody derivatives that overcome these limitations. To this end, we will focus on molecular modification of two EGFR antagonistic monoclonal antibodies currently in clinical use or clinical trials, i.e. C225 and 425, respectively. If successful, the concept to be tested here may be applicable to a wide range of mAbs currently in clinical use or development.",135216,CII,Cancer Immunopathology and Immunotherapy Study Section,A1,1,222751,
7787905,R21,CA,1,,01/07/2010,12/31/2010,PA-08-267,1R21CA135428-01A2,,NCI:171825;,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,PHYSIOLOGY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"NORTH, WILLIAM G;",1885293;,1R21CA135428,01/07/2010,12/31/2011,"AOD use; Active Follow-up; Affinity; Affinity Chromatography; Alcohol or Other Drugs use; Animal Testing; Animals; Antibodies; Antigen Binding Fragment; Apoptotic; Athymic Nude Mouse; Behavior; Binding; Binding (Molecular Function); Biopsy; Blinded; Body Tissues; Brain; Breast; Breast Cancer Cell; Breast Cancer Treatment; Breast Fibrocystic Disease; Breast Neoplasms; Breast Tissue; Breast Tumors; Cancer Patient; Cancer cell line; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Central Nervous System; Chromatography, Affinity; Clinical; Cloning; Cytofluorometry, Flow; DNA Sequence; Data; Detection; Development; Diagnosis; Diagnostic Imaging; Diffuse Cystic Mastopathy; Disease; Disorder; Dose; Ductal; ELISA; Effectiveness; Encephalon; Encephalons; Enzyme-Linked Immunosorbent Assay; Enzymes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Evaluation; External Domain; Extracellular Domain; Fab Fragments; Fab Immunoglobulins; Fibrocystic Breast; Fibrocystic Changes of Breast; Fibrocystic Disease; Fibrocystic Mastopathy; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Forecast of outcome; GFAC; Generalized Growth; Generations; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Health; Heterograft; Human Breast Cancer Cell; IHC; IgG1; Image; Immune Globulins; Immunoglobulin, F(ab) Fragment; Immunoglobulins; Immunoglobulins / Antibodies; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Individual; Intracellular Communication and Signaling; Investigation; Killings; Label; Lead; Legal patent; Libraries; Life; Lobular; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MDA MB 231; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Neoplasms; Measurement; Measures; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Metastatic/Recurrent; Methods; Mice; Mice, Athymic; Mice, Nude; Microfluorometry, Flow; Moab, Clinical Treatment; Molecular; Molecular Interaction; Monitor; Monoclonal Antibodies; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor A1; NMDAR1; NMDARA1 protein; Neoplasm Metastasis; Nervous System, Brain; Nervous System, CNS; Neuraxis; Normal Tissue; Normal tissue morphology; Nude Mice; Organ; Outcome; Patents; Pathology; Pathway interactions; Patients; Pb element; Prognosis; RT-PCR; RTPCR; Radioactivity; Receptor Activation; Receptor Protein; Receptors, N-Methylaspartate; Recurrence; Recurrent; Recurrent disease; Relapse; Relapsed Disease; Residual; Residual Tumors; Residual state; Reverse Transcriptase Polymerase Chain Reaction; Role; Scanning; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Spinal; Testing; Therapeutic Estrogen; Time; Tissue Arrays; Tissue Chip; Tissue Growth; Tissue Microarray; Tissues; Transplantation, Heterologous; Tumor Cell Migration; Tumor Volume; Tumor Weights; Tumors, Residual; Volume, Tumor; Weight; Weights, Tumor; Xenograft; Xenograft procedure; Xenotransplantation; affinity purification; base; biological signal transduction; cancer metastasis; design; designing; disease/disorder; effective therapy; flow cytophotometry; follow-up; heavy metal Pb; heavy metal lead; human tissue; imaging; imaging modality; immunoreactivity; in vivo; malignancy; malignant breast neoplasm; mammary tumor; neoplasm/cancer; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; outcome forecast; pathway; prevent; preventing; public health relevance; receptor; residual disease; response; reverse transcriptase PCR; selective expression; selectively expressed; shRNA; short hairpin RNA; small hairpin RNA; social role; substance use; triple-negative invasive breast carcinoma; tumor; tumor growth; tumor xenograft; whole body imaging; whole body scanning",NMDA receptors in the diagnosis and treatment of breast cancer," 7. Project Narrative/Relevance. Our project focuses on two receptor proteins, and should provide those treating breast cancer patients, with the prospect of new and precise methods for detecting disease in tissue biopsies at an earlier time, for detecting pockets of residual metastases, and for diagnosing relapse soon after a tumor recurs. Of more significance, it is also expected to eventually lead to effective new targeted treatments for most, or all, breast cancer. Such new treatments can then be directly and closely monitored for efficacy by visualizing the receptor protein markers on the tumor.",135428,DT,Developmental Therapeutics Study Section,A2,1,171825,
7798351,R21,CA,1,,02/01/2010,01/31/2011,PA-06-371,1R21CA137364-01A2,,NCI:181830;,2010,NATIONAL CANCER INSTITUTE,,MILWAUKEE,UNITED STATES,PHYSICS,04,627906399,US,WI,532010340,UNIVERSITY OF WISCONSIN MILWAUKEE,"PATCH, SARAH KATHRYN;",9311278;,1R21CA137364,02/01/2010,01/31/2012,"Absorption; Acoustic; Acoustics; Body Tissues; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancer of Prostate; Cell Communication and Signaling; Cell Phone; Cell Signaling; Cellular Phone; Clinical; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Computed Tomography; Computer Programs; Computer software; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Contrast Agent; Contrast Drugs; Contrast Media; Crossmatching, Tissue; Data; Deposit; Deposition; Diagnosis, Ultrasound; Diagnostic; Drops; EMF; EMI scan; Echography; Echotomography; Effectiveness; Electromagnetic; Electromagnetic Energy; Electromagnetic Fields; Electromagnetic Radiation; Electromagnetic Waves; Electromagnetic, Microwave; Electromagnetics; Ensure; Environment; Exploratory/Developmental Grant; Frequencies (time pattern); Frequency; Goals; Heat Losses; Histocompatibility Testing; Illumination; Image; Imaging Procedures; Imaging Techniques; Intracellular Communication and Signaling; Investigators; Lighting; Losses, Heat; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Measurement; Measures; Medical Imaging; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Microbubbles; Microwaves; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Optics; Pattern; Penetration; Physiologic pulse; Pressure; Pressure- physical agent; Process of absorption; Property; Property, LOINC Axis 2; Prostate CA; Prostate Cancer; Prostatic Cancer; Pulse; R21 Mechanism; R21 Program; Radiation, Electromagnetic Fields; Radiation-Total; Radiopaque Media; Relative; Relative (related person); Reporting; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Safety; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Software; Source; Specimen; Spinal Column; Spine; Structure; Surface; System; System, LOINC Axis 4; Technics, Imaging; Telephone, Cellular; Testing; Tissue Crossmatchings; Tissue Typing; Tissues; Tomodensitometry; Tomography, Xray Computed; Translating; Translatings; Ultrasonic Imaging; Ultrasonic Transducer; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound transducer; Ultrasound, Medical; Vertebral column; Width; Work; X-Ray Computed Tomography; Zeugmatography; absorption; animal tissue; backbone; biological signal transduction; cancer imaging; catscan; clinical investigation; computed axial tomography; computer program/software; computerized axial tomography; computerized tomography; design; designing; develop software; developing computer software; diagnostic ultrasound; electric field; electromagnetic field; flexibility; histocompatibility typing; imaging; in vivo; language translation; microwave electromagnetic radiation; microwave radiation; nano particle; nanoparticle; pressure; public health relevance; radiation (unspecified type); radiofrequency; reconstruction; response; soft tissue; software development; sonogram; sonography; sound measurement; tomography; tool; ultrasound; ultrasound imaging; ultrasound scanning; wave (radiation)",Testbed for Quantitative Thermoacoustic Tomography,"  We will validate a completely new contrast mechanism for diagnostic medical imaging in soft tissues. Thermoacoustics may be a boon to applications for which current imaging techniques are woefully inadequate, such as prostate cancer imaging.",137364,BMIT,Biomedical Imaging Technology Study Section,A2,1,181830,
7789755,R21,CA,1,,01/18/2010,12/31/2010,PA-06-371,1R21CA139385-01A1,,NCI:184260;,2010,NATIONAL CANCER INSTITUTE,,BATON ROUGE,UNITED STATES,CHEMISTRY,06,075050765,US,LA,70803,LOUISIANA STATE UNIV A&M COL BATON ROUGE,"VICENTE, MARIA DA GRACA HENRIQUES;",6199057;,1R21CA139385,01/18/2010,12/31/2011,"ATGN; Age related macular degeneration; Antibodies; Antigens; Architecture; Area; Athymic Nude Mouse; Binding; Binding (Molecular Function); Body Tissues; CD66e Antigen; Cancer Treatment; Cancers; Carcinoembryonic Antigen; Carcinoembryonic Antigen CGM2; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5; Carcinoma Cell; Cause of Death; Cells; Cessation of life; Characteristics; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Cola; Colon; Colon Cancer; Colon Carcinoma; Colon Neoplasms; Colonic Carcinoma; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Colonoscopy; Colorectal Cancer; Colorectal Neoplasms; Complement; Complement Proteins; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Development; Disease; Disorder; Dissociation; Drug Design; Drugs; EGFR; ERBB Protein; ERBB1; Early Diagnosis; Electromagnetic, Laser; Endoscopy; Engineering / Architecture; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Fluorescence; Genus Cola; HER1; Histology; Human; Human, General; Image; In Situ; In Vitro; Incidence; Incubated; Investigation; Kinetic; Kinetics; Label; Large Intestine Neoplasm; Large Intestine Tumor; Lasers; Lead; Lesion; Libraries; Ligands; Light; Lytotoxicity; Maculopathy, Age-Related; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Meconium Antigen 100; Medication; Membrane Proteins; Membrane-Associated Proteins; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Mice; Mice, Athymic; Mice, Nude; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mortality; Mortality Vital Statistics; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Neoplasm Metastasis; Neoplasm of the Large Bowel; Nude Mice; Organ Culture; Organ Culture Techniques; Patients; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Photochemotherapy; Photodynamic Therapy; Photofrin; Photoradiation; Photosensitizers; Photosensitizing Agents; Porfimer Sodium; Porphyrins; Programs (PT); Programs [Publication Type]; Public Health; QOL; Quality of life; Radiation, Laser; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Research; Screening for Colorectal Cancer; Screening procedure; Secondary Neoplasm; Secondary Tumor; Series; Solid; Solubility; Solutions; Specificity; Staining method; Stainings; Stains; Surface; Surface Proteins; Symptoms; Techniques; Tetrapyrroles; Tissues; Toxic effect; Toxicities; Transforming Growth Factor alpha Receptor; Treatment outcome; Tumor Cell; Tumor Cell Migration; Tumor of the Colon; Tumor of the Large Bowel; Tumors, Colorectal; adenoma; aminoacid sequence of peptide; aminoacid sequence of protein; anticancer therapy; base; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer imaging; cancer metastasis; cancer therapy; carcinoembryonal antigen; cell type; cellular targeting; chemotherapeutic agent; clinical data repository; clinical data warehouse; clinical investigation; colorectal cancer screening; colorectal neoplasia; conformation; conformational state; cost; cytotoxicity; data repository; design; designing; disease/disorder; drug/agent; early detection; early detection of colorectal cancer; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; fluorophore; heavy metal Pb; heavy metal lead; imaging; immunogen; in vivo; malignancy; metal complex; neoplasm/cancer; neoplasm/cancer photoradiation therapy; neoplastic; neoplastic cell; novel; peptide sequence; phthalocyanine; porphyrin a; programs; protein aminoacid sequence; proto-oncogene protein c-erbB-1; public health medicine (field); public health relevance; rectal; relational database; response; screening; screenings; senile macular disease; success; treatment planning; trial regimen; trial treatment; tumor; uptake",Tumor-specific agents for cancer imaging," RELEVANCE Our proposed program is of great relevance to public health since cancer is still the second most common cause of death in the Nation and, in particular colorectal cancer, is the second most common solid internal malignancy. The effective early detection of tumors as well as tumor infiltrative areas and tumor metastasis will have an enormous impact on treatment planning, tumor response to treatment and overall treatment outcome, will increase the success of cancer treatment with minimal cost, and will increase the patient's quality of life.",139385,SBCA,Synthetic and Biological Chemistry A Study Section,A1,1,184260,
7894063,R21,CA,1,,04/01/2010,03/31/2011,PA-06-418,1R21CA140886-01A1,,NCI:202385;,2010,NATIONAL CANCER INSTITUTE,,BUFFALO,UNITED STATES,,28,824771034,US,NY,14263,ROSWELL PARK CANCER INSTITUTE CORP,"KOZBOR, DANUTA B;",1881866;,1R21CA140886,04/01/2010,03/31/2012,"ABC15; ABCG2; ABCG2 gene; ABCP; ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 Gene; Ablation; Absorption; Affect; Antitumor Response; BCRP; BCRP1; BMDP; Beds; Blood Vessels; Body Tissues; Buffaloes; Carbohydrates; Carcinoma; Cities; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Disease; Disorder; EST157481; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Exhibits; Generations; HNSCC; Head and Neck Carcinoma; Head and Neck Neoplasm (Excluding Central Nervous System); Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Heterograft; Histologic; Histologically; Human; Human, General; Hypoxia; Hypoxic; Induction of Apoptosis; Kinetic; Kinetics; Lesion; MRX; MXR; MXR1; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modality; Morphology; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Oncolytic; Oncolytic viruses; Operation; Operative Procedures; Operative Surgical Procedures; Oxygen Deficiency; Patients; Phase; Phenotype; Photochemotherapy; Photodynamic Therapy; Photosensitizers; Photosensitizing Agents; Poxvirus officinale; Primary Neoplasm; Primary Tumor; Procedures; Process of absorption; Radiation, Visible; Radiation, Visible Light; Recombinants; Regimen; Relative; Relative (related person); Reporting; Roswell Park Cancer Institute; SCCHN; Sampling; Singlet Dioxygen; Singlet Oxygen; Site; Solid Neoplasm; Solid Tumor; Structure; Surgical; Surgical Interventions; Surgical Procedure; Time; Tissues; Transplantation, Heterologous; Tumor Cell; Tumor Tissue; Tumor Volume; Tumor of the Head and Neck; Vaccinia virus; Vascular Permeabilities; Viral Vector; Virus; Virus Replication; Viruses, General; Visible Light; Visible Radiation; Volume, Tumor; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; absorption; cell stroma; chemotherapy; clinical investigation; combination therapy; combined modality treatment; combined treatment; cytotoxic; disease/disorder; epithelial carcinoma; established cell line; head and neck tumor; immunodeficient mouse model; improved; multimodality therapy; neoplasm/cancer photoradiation therapy; neoplastic cell; performance site; pre-clinical; preclinical; public health relevance; pyropheophorbide a; recombinant vaccinia virus; response; surgery; trend; tumor; uptake; vascular; vector; virus multiplication",Enhancing Efficacy of Oncolytic Viriotherapy with PDT, Enhancing Efficacy of Oncolytic Virotherapy with PDT We propose to investigate the effect of photodynamic therapy (PDT)-induced local tumor damage and changes in vascular permeability on the antitumor efficacy of oncolytic virotherapy treatment using xenografts of human head and neck squamous cell carcinomas (HNSCCs) in an immunodeficient mouse model. We hypothesize that optimal PDT treatment conditions resulting in increases in vascular permeability will enhance the uptake and replication of an oncolytic vaccinia virus in tumor tissues leading to ablation of primary tumor and long-term control of disseminated disease.,140886,RTB,Radiation Therapeutics and Biology Study Section,A1,1,202385,
7787139,R21,CA,1,,02/01/2010,01/31/2011,PAR-08-025,1R21CA141404-01A1,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"FARAG, SHERIF S;",6920532;,1R21CA141404,02/01/2010,01/31/2012,"1-Phosphatidylinositol 3-Kinase; 2,6-Dioxo-3-phthalimidopiperidine; 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 3-Phthalimidoglutarimide; ANG; ANG1; ANGPT1; API4; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Administration, Oral; After Care; After-Treatment; Aftercare; Alkylating Agents; Alkylators; Alpha-Phthalimidoglutarimide; Angiogenesis Inhibition; Angiogenic Inhibition; Angiogenin, ribonuclease, RNase A family, 5; Angiopoietin-1; Apoptosis Inhibitor 3; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptotic; Area Under Curve; Assay; BIRC4; BIRC4 protein, human; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 4; Baculoviral IAP Repeat-Containing Protein 5; Bioassay; Bioavailable; Biologic Assays; Biological; Biological Assay; Biopsy Sample; Biopsy Specimen; Biopsy, Core Needle; Blood; Blood Plasma; Blood Precursor Cell; Body Tissues; Bone Marrow; Bortezomib; Cancers; Cell Cycle Arrest; Cell Line; Cell Lines, Strains; CellLine; Cells; Cleaved cell; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Phase II; Clinical Trials, Unspecified; Complex; Core Biopsy; Critical Paths; Critical Pathways; Cytotoxic agent; Cytotoxic drug; Data; Development; Disease; Disorder; Dose; Dose-Limiting; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Administration, Oral; Drug Kinetics; Drug resistance; Drugs; EC 2.7; ELISA; EPR-1; Early-Stage Clinical Trials; Enzyme-Linked Immunosorbent Assay; FGF-2; FGF2; FGFR-3; FGFR3 protein; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Future; Generalized Growth; Growth; HBGF-2; Half-Life; Half-Lifes; Hematopoietic stem cells; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Histones; Hydroxyaryl-Protein Kinase; IAP-Like Protein; IAP4; IMiD3 cpd; Immunofluorescence Microscopy; In Vitro; In complete remission; Investigation; Killings; Kinases; Laboratories; Laboratory Study; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measurement; Medication; Microscopy, Immunofluorescence; Mitosis; Mitosis Stage; Multiple Myeloma; Myeloma, Plasma-Cell; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; Oral; Oral Administration; Outcome; PBMC; PI-3 Kinase; PI-3K; PI3-Kinase; PTK Receptors; Pathogenesis; Pathway interactions; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Phase 1 Clinical Trials; Phase 2 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phase II Clinical Trials; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Inhibition; Phosphotransferases; Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-; Plasma; Progenitor Cells, Hematopoietic; Prostate Epithelial Cell Growth Factor; Prostatropin; Protein Phosphorylation; Proteins; PtdIns 3-Kinase; RTK; Receptor Inhibition; Receptor Protein-Tyrosine Kinases; Refractory; Relapse; Reporting; Research; Resistance; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Serum, Plasma; Sedalis; Serum, Plasma; Survival Rate; Testing; Thalidomide; Time; Tissue Growth; Tissues; Toxic effect; Toxicities; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase JTK4; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; VEGFs; Vascular Endothelial Growth Factors; Vegf; X-linked Inhibitor of Apoptosis; angiogenesis; angiogenin; aurora kinase; aurora-A kinase; auroraA kinase; bFGF; baculoviral IAP repeat-containing protein-4, human; base; biomarker; cleaved; clinical investigation; complete response; conventional therapy; cultured cell line; cytokine; cytotoxic; density; disease/disorder; drug resistant; drug/agent; experience; fibroblast growth factor receptor 3; gene product; human BIRC4 protein; improved; in vivo; intraoral drug delivery; kinase inhibitor; lenalidomide; malignancy; myeloma; myelomatosis; neoplasm/cancer; novel; ontogeny; pathway; phase 1 study; phase 1 trial; phase 2 study; phase 2 trial; phase I trial; phase II trial; pre-clinical; preclinical; preclinical study; protocol, phase I; protocol, phase II; public health relevance; resistance to Drug; resistant; resistant to Drug; response; study, phase II; survivin",Multiple kinase target inhibition with EMND-2076 in multiple myeloma," PROJECT NARRATIVE Multiple myeloma (MM) remains an incurable cancer with current treatment, indicating the need for continued investigation and development of new drugs. In our laboratory, we have investigated a novel drug, ENMD- 2076, for its activity against MM cells. We have shown that ENMD-2076 potently kills myeloma cells, and appears to target a number of pathways on which the myeloma cells critically depend for their growth and survival. Our studies suggest that ENMD-2076 has promise for the treatment of MM, and that it should undergo clinical investigation. No significant clinical experience with ENMD-2076 exists. Therefore, to develop this novel agent in MM, we propose to conduct a phase I trial to determine the toxicity and safe dose of ENMD- 2076 in patients with relapsed or resistant MM. The laboratory studies that will accompany the trial, including determination of the drug's concentration in blood after different doses, and its biological activity in patients will give better understanding of its clinical mechanism of action and the way it may be best developed in MM. The results of our proposed trial hold promise to eventually improve the outcome of patients with this disease.",141404,CONC,Clinical Oncology Study Section,A1,1,319550,
7915023,R21,CA,1,,04/01/2010,03/31/2011,PAR-08-147,1R21CA141836-01A2,,NCI:337125;,2010,NATIONAL CANCER INSTITUTE,,ATLANTA,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HU, XIAOPING P;OLSON, JEFFREY J;SHIM, HYUNSUK  (contact);",1878969 (contact);1882523;1971817;,1R21CA141836,04/01/2010,03/31/2012,"21+ years old; 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; Adjuvant Therapy; Adult; After Care; After-Treatment; Aftercare; Alanine; Alanine, L-Isomer; Animals; Anti-Oncogenes; Antioncogenes; Appetite stimulated; Astrocytoma, Grade IV; Back; Behavior; Biochemical; Biopsy; Body Tissues; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Cancer Induction; Cancer Radiotherapy; Cerebrospinal Fluid; Cerebrum; Chiro-Inositol; Classification; Clinical; Clinical Evaluation; Clinical Testing; Common Rat Strains; Correlative Study; Creatine; Data; Depression; Dorsum; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Early treatment; Effectiveness; Emerogenes; Emotional Depression; Endogenous depression; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Essex brand of temozolomide; Evaluation; Funding; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Glioblastoma; Glycine, N-(aminoiminomethyl)-N-methyl-; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; H+ element; HDAC; HDAC Agent; HDAC Proteins; Histone Deacetylase; Histone Deacetylase Inhibitor; Histone Deacetylation; Human, Adult; Hydrogen Ions; Image; Increased food appetite; Individual; Inositol; Institution; L-Alanine; Locomotor Activity; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Mammals, Rats; Mass Spectrum; Mass Spectrum Analysis; Measures; Mental Depression; Mesoinositol; Metabolic; Methods; Modeling; Modification; Monitor; Mood stabilizers; Moods; Motor Activity; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Newly Diagnosed; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncologist; Operation; Operative Procedures; Operative Surgical Procedures; Patient Self-Report; Patients; Phase; Photometry/Spectrum Analysis, Mass; Primary Brain Neoplasms; Procedures; Protons; QOL; Quality of life; Radiation therapy; Radiotherapeutics; Radiotherapy; Rat; Rattus; Recurrence; Recurrent; Risk; SAHA; Schering brand of temozolomide; Schering-Plough brand of temozolomide; Self-Report; Social Interaction; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Suberoylanilide Hydroxamic Acid; Surgical; Surgical Interventions; Surgical Procedure; Survey Instrument; Surveys; Symptoms of depression; Systematics; Technology; Temodal; Temodar; Testing; Therapeutic; Therapeutic Effect; Time; Tissues; Treatment Period; Tumor Suppressing Genes; Tumor Suppressor Genes; Vorinostat; Zolinza; adult human (21+); alternative treatment; base; biomarker; brain metabolism; carcinogenesis; clinical depression; clinical effect; clinical test; depressive; depressive symptoms; disturbance in affect; effective therapy; experience; glioblastoma multiforme; imaging; imaging modality; imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-; improved; increased appetite; increased hunger; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; irradiation; methazolastone; mood alteration; mood and affect disturbance; mood disturbance; mood dysfunction; neuronal; oncosuppressor gene; pre-clinical; preclinical; public health relevance; research clinical testing; response; restoration; spinal fluid; spongioblastoma multiforme; standard of care; suberanilohydroxamic acid; surgery; temozolomide; theories; tool; treatment days; treatment duration; tumor; tumors in the brain; vector",Using Proton MRS to Predict Response of SAHA treatment in Glioblastoma," During carcinogenesis, tumor-suppressor genes can be silenced by aberrant histone deacetylation. This epigenetic modification has become an important target for tumor therapy. Vorinostat (SAHA, Zolinza; Merck & Co., Inc., Whitehouse Station, NJ) is an orally active, potent inhibitor of aberrant histone deacetylation activity that is currently being evaluated in glioblastoma patients. In this study, we will establish an important clinical tool to predict therapeutic response soon after treatment initiation. Our MRS- based tool will aid clinicians in early modification of SAHA treatment or in seeking alternative treatments in those with glioblastoma.",141836,ZRG1,Special Emphasis Panel,A2,1,337125,
7766679,R21,CA,1,,01/15/2010,12/31/2010,PA-06-351,1R21CA142921-01,,NCI:253087;,2010,NATIONAL CANCER INSTITUTE,,MEMPHIS,UNITED STATES,,09,067717892,US,TN,38105,ST. JUDE CHILDREN'S RESEARCH HOSPITAL,"COX, CHERYL LORANE;",2084848;,1R21CA142921,01/15/2010,12/31/2011,"21+ years old; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Address; Adult; Adverse Late Effects; Affect; After Care; After-Treatment; Aftercare; Age; Age-Years; Aging; Am 80; Am80; Availability of Health Services; Behavior; Benzoic acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-; CCSS; Cancer Survivor; Cancer Treatment; Cancers; Care, Health; Caring; Childhood; Childhood Cancer Survivor Study; Childhood Cancers; Clinic; Cohort Studies; Communities; Concurrent Studies; Development; Economics; Enrollment; Evaluation; Feasibility Studies; Foundations; Future; Health; Health Services Accessibility; Healthcare; Heterogeneity; Human, Adult; Infrastructure; Intervention; Intervention Strategies; Investigators; Knowledge; LTS; Late Effects; Length; Life; Long-Term Survivors; Longitudinal Surveys; Malignant Childhood Neoplasm; Malignant Childhood Tumor; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Pediatric Neoplasm; Malignant Pediatric Tumor; Malignant Tumor; Methods; Minority; Modeling; Needs Assessment; North America; Participant; Patient Self-Report; Perception; Performance; Population; Prevention strategy; Preventive strategy; Public Health; QOL; Quality of life; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Respondent; Rural; Sampling; Sampling Studies; Self-Report; Senescence; Services; Shapes; Stratification; Survey Instrument; Surveys; Surveys, Longitudinal; Survivors; Survivors, Long-Term; Time; Triage; access to services; access to treatment; adult human (21+); adult youth; aged; anticancer therapy; availability of services; base; cancer care; cancer therapy; childhood cancer survivor; cohort; design; designing; enroll; experience; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; instrument; interest; interventional strategy; malignancy; meetings; neoplasm/cancer; pediatric; pediatric cancer; pediatric cancer survivor; pediatric neoplasm/cancer; primary care setting; prospective; psychologic; psychological; public health medicine (field); public health relevance; response; rural area; senescent; social; young adult",Investigating the Needs of Childhood Cancer Survivors: The UnReported Experience," RELEVANCE STATEMENT The pediatric malignancy cure rate is now nearly 80%, and the growing population of childhood cancer survivors comprises 1 in 640 young adults 20 to 39 years of age. Within the Childhood Cancer Survivor Study (CCSS), North America's largest survivor cohort, 26% are now e 41 years of age, and 2.8% are e 51 years of age. While the late effects of childhood cancer and its treatment have been studied extensively, we know very little about the self-perceived health care needs or the long-term health experience of these adult survivors. The results of this feasibility study will inform and lay the groundwork for longitudinal surveys that will provide the basis for models of comprehensive cancer care that specifically target the needs of aging childhood cancer survivors.",142921,HSOD,Health Services Organization and Delivery Study Section,,1,253087,
7771029,R21,CA,1,,01/04/2010,12/31/2010,PA-06-386,1R21CA143242-01,,NCI:216226;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078198520,US,WA,981011466,GROUP HEALTH COOPERATIVE,"CHUBAK, JESSICA ;",9245416;,1R21CA143242,01/04/2010,12/31/2011,"Active Follow-up; Affect; Algorithms; Au element; Cancer Burden; Cancer Patient; Cancer Prognosis; Cancer Relapse; Cancer Research Network; Cancer Survivor; Cancer Survivorship; Cancer of Breast; Cancers; Care, Health; Data; Data Set; Data Sources; Dataset; Delivery of Health Care; Development; Diagnosis; Drugs; Enrollment; Epidemiology / Surveillance; Event; Forecast of outcome; Funding; Future; Goals; Gold; Health; Health Care Utilization; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Health Sciences, Allied and Health Services Delivery; Health system; Healthcare; Healthcare Delivery; Healthcare Systems; Integrated Delivery Systems; Investigators; Longitudinal Studies; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Manuals; Medical Records; Medical Surveillance; Medicare; Medication; Methods; Michigan; NCI; NCI Organization; National Cancer Burden; National Cancer Institute; Outcome; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacies; Pharmacy facility; Population; Predictive Value; Prescription; Probability; Prognosis; Public Health; Publishing; QOL; Quality of life; Records; Recurrence; Recurrent; Research; Research Personnel; Researchers; Sampling; Second Cancer; Second Primary Cancers; Secondary Malignancy; Secondary Malignancy (After Treatment of Primary Cancer); Secondary Malignant Neoplasm; Sensitivity and Specificity; Site; Source; Sources, Data; Specificity; Surveillance; Survivors; System; System, LOINC Axis 4; Systems, Health Care; Systems, Integrated Delivery; Testing; Time; Title 18; Training; Validation; Washington; Woman; Work; abstracting; adjudicate; cancer recurrence; cancer registry; cohort; cost; drug/agent; electronic data; enroll; experience; follow-up; health care delivery; health care service utilization; health insurance for disabled; health services utilization; healthcare service utilization; healthcare utilization; improved; innovate; innovation; innovative; long-term study; malignancy; malignant breast neoplasm; neoplasm registry; neoplasm/cancer; outcome forecast; population based; prescription procedure; prevent; preventing; public health medicine (field); public health relevance; response; secondary cancer; treatment utilization; tumor registry",Algorithms to Identify Second Breast Cancer Events from Electronic Data," Project Narrative/Relevance  As the number of breast cancer survivors grows, research on breast cancer prognosis and quality of life is becoming increasingly important to public health; however, current methods for collecting data on breast cancer recurrences and second primary breast cancers are either time-consuming and costly or have not yet been validated. Being able to identify cancer breast cancer outcomes from automated healthcare data is necessary for conducting large-scale, population-based studies to identify and modify factors that impact the prognosis and quality of life of women with breast cancer.",143242,EPIC,Epidemiology of Cancer Study Section,,1,216226,
7773490,R21,CA,1,,01/07/2010,12/31/2010,PA-06-371,1R21CA143331-01,,NCI:167077;,2010,NATIONAL CANCER INSTITUTE,,EVANSTON,UNITED STATES,CHEMISTRY,09,160079455,US,IL,602081110,NORTHWESTERN UNIVERSITY,"BURDETTE, JOANNA E;MEADE, THOMAS J. (contact);",2067578 (contact);6777129;,1R21CA143331,01/07/2010,12/31/2011,"Address; Animals; Applications Grants; Athymic Nude Mouse; Benign; Binding; Binding (Molecular Function); Biopsy; Body Tissues; Breast; Breast Neoplasms; Breast Tumors; Cancer of Breast; Cancer of Endometrium; Cancers; Carcinoma of Endometrium; Cell Function; Cell Nucleus; Cell Process; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Contrast Agent; Contrast Drugs; Contrast Media; Corpus Luteum Hormone; Cytoplasmic Membrane; DNA; Delta4-pregnene-3,20-dione; Deoxyribonucleic Acid; Development; Diagnosis; Diagnosis, Ultrasound; Disease; Disorder; Early Diagnosis; Echography; Echotomography; Endocrine Gland Secretion; Endometrial Cancer; Endometrial Carcinoma; Endometrial Neoplasms; Endometrial Tumor; Expression Profiling; Expression Signature; Forecast of outcome; Gadolinium; Gd element; Gene Transcription; Genetic Transcription; Grant Proposals; Grants, Applications; Hormone Receptor; Hormones; Image; In Vitro; In element; Indium; Lesion; Location; MMG; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Cell; Malignant Neoplasm of the Uterus; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Uterus; Malignant Uterine Neoplasm; Malignant Uterine Tumor; Malignant neoplasm of breast; Mammalian Cell; Mammals, Mice; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Mammogram; Mammography; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Mice, Athymic; Mice, Nude; Modeling; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monitor; Murine; Mus; NMR Imaging; NMR Tomography; Names; Neoplasm Metastasis; Neoplasm of the Endometrium; Nuclear Magnetic Resonance Imaging; Nucleus; Nude Mice; Optics; Organ; Pain; Painful; Patients; Permeability; Plasma Membrane; Pregn-4-ene-3,20-dione; Pregnenedione; Progesterone; Progesterone Receptors; Prognosis; RNA Expression; Radiopaque Media; Receptor Protein; Receptors, Progesterone; Receptors, Progestin; Receptors, Steroid; Recurrence; Recurrent; Research; Research Proposals; Secondary Neoplasm; Secondary Tumor; Series; Solutions; Specificity; Steroid Compound; Steroid Receptors; Steroids; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Hormone; Therapeutic Progesterone; Therapeutic Steroid Hormone; Tissues; Transcription; Transcription, Genetic; Tumor Cell Migration; Tumor Tissue; Tumor Volume; Tumor of the Endometrium; Tumor of the Uterus; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Uterine Cancer; Uterine Neoplasms; Uterine Tumor; Uterus Cancer; Uterus Neoplasms; Volume, Tumor; Zeugmatography; base; cancer cell; cancer diagnosis; cancer imaging; cancer metastasis; cell imaging; cellular imaging; diagnostic ultrasound; disease/disorder; early detection; imaging; improved; in vivo; malignancy; malignant breast neoplasm; mammary; mammary tumor; molecuar profile; molecular marker; molecular signature; mouse model; neoplasm/cancer; noninvasive diagnosis; outcome forecast; plasmalemma; progesterone receptor; public health relevance; receptor; receptor binding; receptor function; response; sonogram; sonography; sound measurement; steroid hormone; tool; transcription factor; tumor; tumor growth; tumor xenograft; ultrasound; ultrasound imaging; ultrasound scanning",Progesterone Contrast Agents for MRI,"  The determination of molecular markers in breast and endometrial cancers is necessary because these markers decide the prognosis and treatment options for patients, but this requires invasive biopsies that are painful and subject to error due to the use of only small portions of a tumor. The proposed research develops cancer-targeted magnetic resonance imaging contrast agents that can be used to noninvasively diagnose and molecularly characterize entire tumors and metastases in order to improve treatment decisions and monitor these diseases and recurrences.",143331,ZRG1,Special Emphasis Panel,,1,167077,
7780476,R21,CA,1,,02/01/2010,01/31/2011,PA-08-267,1R21CA143711-01,,NCI:204543;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,OTHER BASIC SCIENCES,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"AMBROS, VICTOR ;",7713196;,1R21CA143711,02/01/2010,01/31/2012,"Active Follow-up; Affect; Avian Myelocytomatosis Viral Oncogene Homolog; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Behavior; Biogenesis; Biosynthetic Proteins; C elegans; C.elegans; Caenorhabditis elegans; Cancer cell line; Cancers; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Chemicals; Circulatory Collapse; Clinic; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Employee Strikes; Epistasis; Epistasis, Genetic; Epistatic Deviation; FDA approved; Family; Fingers; Future; GeneHomolog; Genes; Genetic; Genetic Epistasis; Goals; HCC; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Homolog; Homologous Gene; Homologue; Human; Human, General; Interaction Deviation; Intracellular Communication and Signaling; LIN; Libraries; Lobular Intraepithelial Neoplasia; Lobular Neoplasia; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MYC; MYC gene; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Measures; Medication; Micro RNA; MicroRNAs; Modeling; Mother Cells; Nematoda; Nematodes; Oncogenes, myc; Oncogenic; Origin of Life; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plasmids; Play; Primary carcinoma of the liver cells; Progenitor Cells; Proteins; RNA-Binding Proteins; RNA-Protein Interaction; Recombinant Proteins; Recombinants; Role; Shock; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Strikes; Strikes, Employee; System; System, LOINC Axis 4; Testing; Tetracycline Antibiotic; Tetracyclines; Time; Transgenic Organisms; Triage; Tumor Suppressor Proteins; anti-cancer therapeutic; anticancer therapeutic; base; biological signal transduction; cancer cell; cell growth; chemical genetics; circulatory shock; clinical applicability; clinical application; cultured cell line; drug/agent; follow-up; gain of function; gene product; gene x gene interaction; genetic epistases; in vivo; inhibitor; inhibitor/antagonist; loss of function; malignancy; miRNA; neoplasm/cancer; pathway; pluripotency; protein function; public health relevance; response; roundworm; small molecule; small molecule libraries; social role; tissue culture; transgenic; tumor suppressor",Chemical genetics of LIN-28 in C. elegans," HEALTH RELEVANCE  LIN-28 plays a major role in regulating the biogenesis of the tumor suppressor miRNAs of the let-7 family and does so downstream of Myc oncogene signaling. LIN-28 therefore represents a potential druggable target in the context of human cancer. We propose to utilize the nematode C. elegans as an in vivo system to efficiently screen for small molecule drugs that can inhibit LIN-28 activity. The chemical compounds the we identify by their inhibition of LIN-28 function in C. elegans will form the basis for further testing of their ability to inhibit LIN-28 in mammalian cancer lines. Since we will include in our screens libraries of FDA-approved drugs, there is the prospect of almost immediate clinical application of anti-LIN-28 drugs that we will identify.",143711,CSRS,Cellular Signaling and Regulatory Systems Study Section,,1,204543,
7876599,R21,CA,1,,02/01/2010,01/31/2011,PA-08-208,1R21CA149554-01,,NCI:229680;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"LAMPE, PAUL D;",3172804;,1R21CA149554,02/01/2010,01/31/2012,"Acute; Affect; Amino Acid Substitution; Animal Model; Animal Models and Related Studies; Animals; Anti-Oncogenes; Antibodies; Antioncogenes; Apoptosis; Apoptosis Pathway; Area; Belief; Biology; Body Tissues; C-K-RAS; C-terminal; Cancer Biology; Cancer Cause; Cancer Etiology; Cancer Induction; Carcinoma; Casein Kinase 1; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cessation of life; Characteristics; Communicating Junction; Communication; Complex; Connexin 43; Connexin43; Connexins; Cx43; DNA Alteration; DNA mutation; Death; Development; Disease; Disease Progression; Disorder; Disseminated Malignant Neoplasm; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Ductal Cell; Ductal Epithelial Cell; EGFR; ERBB Protein; ERBB1; Emerogenes; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Event; Exhibits; Extracellular Signal-Regulated Kinase Gene; Gap Junction Proteins; Gap Junctions; Gastrointestinal Tract, Pancreas; Gene Alteration; Gene Mutation; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Growth; HER1; Histologic; Histologically; Human; Human, General; Incidence; Intracellular Communication and Signaling; Intracellular Second Messengers; Invasive Lesion; Investigation; Investigators; Ions; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Knock-in; Knock-in Mouse; L-Serine; Lead; Lesion; Low-resistance Junction; MAP Kinase Gene; MAPK; Malignant Pancreatic Neoplasm; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane; Metastatic Cancer; Metastatic Malignant Neoplasm; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Mortality; Mortality Vital Statistics; Murine; Mus; Mutation; Nexus; Nexus Junction; Normal Tissue; Normal tissue morphology; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Pancreas; Pancreas Cancer; Pancreas Ductal Adenocarcinoma; Pancreatic; Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Pathologist; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphorylation Site; Physiologic; Physiological; Play; Prevention; Protein Kinase CK1; Protein Kinase CKI; Protein Phosphorylation; Protein Trafficking; Proteins; RASK2; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Research Personnel; Researchers; Resected; Resistance; Role; Second Messenger Systems; Second Messengers; Sequence Alteration; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Site; Speed; Speed (motion); Stimulus; Survival Rate; Symptoms; Testing; Time; Tissue Growth; Tissues; Traffickings, Protein; Transforming Growth Factor alpha Receptor; Tumor Suppressing Genes; Tumor Suppressor Genes; United States; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cancer location; cancer progression; cancer site; carcinogenesis; casein kinase I; cell growth; cell type; cultured cell line; disease/disorder; drug/agent; epithelial carcinoma; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; intercellular communication; membrane structure; migration; model organism; mouse model; mutant; neoplasm progression; neoplastic progression; oncosuppressor gene; ontogeny; pathway; protein transport; proto-oncogene protein c-erbB-1; public health relevance; resistant; response; second messenger; small molecule; social role; tumor; tumor progression; tumorigenesis; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog",Cx43 phosphorylation modulates Kras mediated pancreas cancer progression," Project Narrative We hypothesize that Cx43 phosphorylation is critical for the control of cell growth and is modulated during pancreas carcinogenesis affecting its progression. Since drugs that affect Cx43 activity and gap junctional communication are under development, understanding how these factors affect progression could ultimately lead to better treatment of this lethal disease.",149554,TME,Tumor Microenvironment Study Section,,1,229680,
7788975,R21,DA,1,,02/01/2010,01/31/2011,PA-06-181,1R21DA026541-01A1,,NIDA:223652;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,Beltsville,UNITED STATES,,05,021883350,US,MD,207053111,PACIFIC INSTITUTE FOR RES AND EVALUATION,"STOUT, ROBERT L;",1873416;,1R21DA026541,02/01/2010,01/31/2012,"Active Follow-up; Addiction, Cocaine; Affect; Alcohol Drinking; Alcohol consumption; Anxiety Disorders; Attitude; Behavior; Biological; Body Dysmorphic Disorder; Client; Clinic; Clinical; Clinical Data; Cocaine Dependences; Communities; Comorbidity; Counseling; Data; Dependence; Dependences, Cocaine; Depression; Deterioration; Diagnosis; Disease; Disease remission; Disorder; Drug Use Disorder; Drug abuse; Drug usage; Drugs; Ensure; EtOH drinking; Event; Frequencies (time pattern); Frequency; Funding; Future; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare worker; History; Individual; Influentials; Intervention; Intervention Strategies; Interview; Lead; Life; Longitudinal Studies; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mental Depression; Mental disorders; Mental health disorders; Motivation; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Outcome; PTSD; Patients; Pattern; Pb element; Personality Disorders; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; Population; Post-Traumatic Stress Disorders; Preventive Intervention; Procedures; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychopathology; Qualifying; RMSN; Recording of previous events; Recovery; Recruitment Activity; Relapse; Remission; Research; Research Resources; Resort; Resources; Risk Factors; Sampling; Self Efficacy; Services; Social Support System; Social support; Statistical Methods; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Stressful Event; Substance Use Disorder; Support System; Survey Instrument; Surveys; System; System, LOINC Axis 4; Testing; Time; TimeLine; Unspecified Mental Disorder; abnormal psychology; abuse of drugs; abuses drugs; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; cocaine use; coping; design; designing; disease/disorder; drug use; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; follow-up; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; high risk; improved; insight; instrument; interventional strategy; long-term study; medical personnel; mental illness; pilot study; preventional intervention strategy; programs; psychologic; psychological; psychological disorder; public health relevance; recruit; social; social support network; synergism; traumatic neurosis; treatment provider",Longitudinal Study of Mechanisms of Drug Abuse Recovery-Pilot," Most people who qualify for a drug abuse or dependence diagnosis do not use professional treatment for this condition; nonetheless, many are able to overcome the disorder and lead normal lives. We know very little about how people achieve remission without resorting to professional treatment; such information will be valuable in devising interventions for persons with drug use disorders that can take advantage of the strengths that people bring with them, and in coping with the risk factors that can lead to deterioration. This study represents the beginning of a research program on recovery and relapse in drug use disorders in the community.",26541,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",A1,1,223652,
7784585,R21,DA,1,,02/01/2010,01/31/2011,PA-08-218,1R21DA027146-01A1,,NIDA:258925;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW BRUNSWICK,UNITED STATES,PSYCHOLOGY,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"GREENE, KATHRYN L;",1895952;,1R21DA027146,02/01/2010,01/31/2012,"AOD use; Active Follow-up; Address; Adolescent; Adolescent Youth; Adoption; Advertisements; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Approaches to prevention; Attitude; Belief; Chemical Class, Alcohol; Cognitive; Communication; Communities; Control Groups; Curriculum; Decision Making; Deterioration; Development; Drug Precursors; Drug usage; Drugs; Educational Curriculum; Educational process of instructing; Educational workshop; EtOH drinking; Expectancy; Feasibility Studies; Focus Groups; Fostering; Foundations; Friends; Future; Goals; Human Resources; Intervention; Intervention Strategies; Intervention Studies; Interview; Investigation; Investigators; Leadership; Life; Manpower; Measurement; Measures; Medication; Modeling; Motivation; NIDA; National Institute of Drug Abuse; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Participant; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Prevention; Prevention approach; Prevention program; Preventive Intervention; Pro-Drugs; Procedures; Process; Prodrugs; Production; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Review Literature; School-Age Population; Schools; Services; Smoking; Students; Teaching; Testing; Thinking; Thinking, function; Time; Tobacco; Trials, Randomized Clinical; Work; Workshop; Youth; Youth 10-21; adolescent substance abuse; adolescent substance use; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; brief intervention; combat; design; designing; drug abuse prevention; drug addiction prevention; drug use; drug use prevention; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; follow-up; high school; innovate; innovation; innovative; intervention development; interventional strategy; juvenile; juvenile human; literacy; middle school; novel; peer; personnel; preventional intervention strategy; programs; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; school age; skills; social; substance use; substance use prevention; teacher; theories; therapy development; treatment development; youth substance abuse; youth substance use",Active Involvement in Creating High School Substance Use Prevention Messages," Project Narrative Adolescent substance abuse remains a significant public health concern and media literacy-based interventions appear to be a promising approach to addressing this problem that deserves to be evaluated rigorously. This study provides a feasibility test of a media literacy intervention and a preliminary look at how it functions, with what effects, and how it may be implemented on a broader scale. The long-term objective of this project is to develop a component of an effective brief school-based prevention program to reduce adolescent substance use for testing in a randomized clinical trial.",27146,CIHB,Community Influences on Health Behavior,A1,1,258925,
7771002,R21,DA,1,,02/01/2010,01/31/2011,PA-06-181,1R21DA027786-01,,NIDA:189114;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,TUCSON,UNITED STATES,PHARMACOLOGY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"VARGA, EVA V;",7730951;,1R21DA027786,02/01/2010,01/31/2012,"AM 1241; AM1241; Addiction, Drug; Addiction, Opiate; Adverse effects; Agonist; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Astrocytes; Astrocytus; Astroglia; Attenuated; Biological Models; CB2 Receptor; Cannabinoids; Cell Communication and Signaling; Cell Signaling; Cell model; Cellular model; Central Nervous System; Chemical Dependence; Common Rat Strains; Contin, MS; Dependence, Drug; Dependence, Opiate; Development; Dose; Drug Addiction; Drug Combinations; Drug Dependency; Drugs; Event; Exhibits; Exposure to; Future; Glia; Glial Cells; Hand; Hortega cell; Hyperalgesia; Hyperalgesic Sensations; INFLM; In Vitro; Inflammation; Infumorph; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigation; Kadian; Kolliker's reticulum; Lead; MSir; Mammals, Mice; Mammals, Rats; Measures; Mediating; Medication; Medulla Spinalis; Mice; Microglia; Model System; Models, Biologic; Molecular; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Murine; Mus; Neonatal; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neuropathy; Neurotransmitters; Non-neuronal cell; Opiate Addiction; Opioid; Opioid Analgesics; Oramorph; Oramorph SR; Pain; Painful; Painless; Patients; Pb element; Peripheral; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Rat; Rattus; Receptor Mediated Signal Transduction; Receptor, Cannabinoid, CB2; Regulation; Research; Role; Roxanol; Signal Transduction; Signal Transduction Systems; Signaling; Spinal; Spinal Cord; Statex SR; Stimulus; Tactile Hyperalgesias; Treatment Side Effects; Withdrawal; Work; allodynia; analgesia; attenuation; base; biological signal transduction; chronic pain; chronic painful condition; design; designing; drug development; drug/agent; experiment; experimental research; experimental study; gitter cell; heavy metal Pb; heavy metal lead; hyperalgia; immunoreactivity; in vitro Model; in vivo; inflammatory neuropathic pain; inhibitor; inhibitor/antagonist; mesoglia; microglial cell; microgliocyte; nerve cement; nerve injury; neural injury; neuronal; neuropathic; neuropathic pain; neurotransmitter release; novel; opioid addiction; opioid dependence; painful neuropathy; perceptual stimulus; perivascular glial cell; pharmacophore; physicochemical phenomena related to the senses; prevent; preventing; public health relevance; research study; response; sensory stimulus; side effect; social role; therapy adverse effect; treatment adverse effect",A novel pharmacological target to prevent sustained-morphine-mediated pain sensit," NARRATIVE:  Prolonged morphine treatment leads to a gradual decline of pain relief. Consequently, clinicians need to use steadily increasing morphine doses to manage severe chronic pain (analgesic tolerance). Higher morphine doses on the other hand are more likely to cause serious side effects and may also lead to drug addiction. Interestingly, recently it was demonstrated that sustained exposure to morphine actually increases the sensitivity of patients to painful (hyperalgesia) and even to normally painless (allodynia) stimuli, contributing to the need for increased morphine doses in the treatment of chronic pain. Activation of spinal glia was shown to play a crucial role in the development of such paradoxical sensitization to sensory stimuli upon sustained morphine treatment. Accordingly, glial inhibitors were found to reduce both neuropathic pain sensitization and morphine tolerance. In the present proposal we intend to explore the utility of a novel pharmacological approach -activation of the CB2 cannabinoid receptor type - to inhibit spinal microglia activation during sustained morphine treatment. By preventing glia activation, opioid and CB2 agonist co-treatment is expected to produce more efficient pain relief without adaptive pain sensitization during sustained treatment. Thus, with such drug combinations, we may be able to achieve longer- lasting pain relief with lower morphine doses, reducing the likelihood of dangerous side effects and opiate addiction in the treatment of chronic pain.",27786,SCS,Somatosensory and Chemosensory Systems Study Section,,1,189114,
7771436,R21,DA,1,,02/01/2010,01/31/2011,PA-08-264,1R21DA027872-01,,NIDA:187397;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SEATTLE,UNITED STATES,NONE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HAGGERTY, KEVIN P;",8191978;,1R21DA027872,02/01/2010,01/31/2012,"0-11 years old; 12-20 years old; Active Follow-up; Adolescence; Adoption; Age; Attitude; Behavior; Behavioral; Characteristics; Child; Child Youth; Children (0-21); Client; Climate; Clinic; Communities; Community Health; Conflict; Conflict (Psychology); Controlled Study; Counselor; Development; Drug abuse; Drugs; Education; Education Level; Educational Background; Educational aspects; Effectiveness; Ensure; Family; Family member; Health Care Research; Health Services; Health Services Evaluation; Health Services Research; Healthcare Research; History; Human; Human, Child; Human, General; Intervention Studies; Knowledge; Length; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Marital Status; Medical Care Research; Medication; Mental Health; Mental Hygiene; Meteorological Climate; Modeling; Models, Theoretic; Parents; Pharmaceutic Preparations; Pharmaceutical Preparations; Prevention; Prevention program; Problem Solving; Problem behavior; Process; Professional counselor; Programs (PT); Programs [Publication Type]; Psychological Health; Psychological reinforcement; Recording of previous events; Reinforcement; Reinforcement (Psychology); Reporting; Research Design; Rewards; Services; Social Development; Study Type; Teen; Teenagers; Teens; Testing; Theoretical model; Therapeutic; Time; Violence; abuse of drugs; abuses drugs; adolescence (12-20); base; behavioral problem; children; climatic; design; designing; drug abuse prevention; drug addiction prevention; drug use prevention; drug/agent; family management; follow-up; health care service; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; improved; inner city; prevention service; programs; public health relevance; response; risky sexual behavior; services research; skills; study design; substance use prevention; success; teen years; teenage; treatment center; violent; violent behavior; youngster",Exploring Implementation of Drug Abuse Prevention in Treatment Settings," This study should answer preliminary questions about the feasibility of disseminating self-study prevention programs through treatment and human services agencies, and generate valuable knowledge about barriers, enablers and adaptations. This knowledge can be used in subsequent projects designed to test various strategies for improving the adoption of tested and effective prevention efforts in existing health services agencies and to evaluate the level of supports necessary to ensure quality implementation.",27872,NIDA,Neuropharmacology Research Subcommittee,,1,187397,
7785685,R21,DC,1,,01/22/2010,12/31/2010,PA-06-181,1R21DC009986-01A1,,NIDCD:214063;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"KOHANE, DANIEL S;",6086590;,1R21DC009986,01/22/2010,12/31/2011,"1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; Acoustic; Acoustics; Address; Affect; Amides; Animals; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antibiotics, Combined; Bacteria; Biological; Boxing; Brain; Bupivacaine; Chemicals; Childhood; Combinations, Antibiotic; Combined Antibiotics; Conduction-Blocking Anesthetics; Development; Disease; Disorder; Drug Combinations, Antibiotic; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; Ear; Ear structure; Eardrum; Effectiveness; Encephalon; Encephalons; Enhancers; Evaluation; Formulation; Formulations, Drug; Gel; Hearing; High Prevalence; Hydrogels; In Situ; In Vitro; Infection; Investigation; Local Anesthetics; Lytotoxicity; Medication; Membrana Tympanica; Miscellaneous Antibiotic; Nervous System, Brain; Otitis Media; Pain; Painful; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Recurrence; Recurrent; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Site; Skin; System; System, LOINC Axis 4; Time; Toxic effect; Toxicities; Tympanic Membrane; Tympanic membrane structure; United States; anti-microbial agent; anti-microbial drug; antibiotic resistant; antimicrobial agent; antimicrobial drug; bactericidal; bactericide; base; biocompatibility; biomaterial compatibility; cytotoxicity; design; designing; disease/disorder; drug/agent; ear drum; ear infection; hearing perception; improved; in vivo; knowledge base; middle ear; pathogenic bacteria; pediatric; prevent; preventing; public health relevance; resistant; response; sound perception",Trans-tympanic treatment of otitis media," Middle ear infections are the most commonly treated infections in childhood. The purpose of this application is to develop a means of treating middle ear infections by applying a gel in the outer ear, once. Chemicals in the gel will help antibiotics cross the eardrum; the gel holds it in place. This approach could prevent antibiotic resistance and toxicity.",9986,CRFS,Clinical Research and Field Studies of Infectious Diseases Study Section,A1,1,214063,
7789558,R21,EB,1,,02/01/2010,01/31/2011,PA-06-418,1R21EB008785-01A2,,NIBIB:214408;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CLEMSON,UNITED STATES,BIOMEDICAL ENGINEERING,03,042629816,US,SC,296345702,CLEMSON UNIVERSITY,"NAGATOMI, JIRO ;",8251146;,1R21EB008785,02/01/2010,01/31/2012,"3T3 Cells; Acrylamides; Actinic Rays; Address; Adhesiveness; Adhesives; Age; Animals; Arm; Autologous Fibrin Tissue Adhesive; Biocompatible Materials; Biological; Biomaterials; Biomechanics; Bladder; Bladder Injury; Bladder Tissue; Body Tissues; Bolus; Bolus Infusion; Businesses; Catheters; Cell surface; Cells; Chemicals; Cicatrix; Clinical Treatment; Common Rat Strains; Complex; Complication; Crosslinker; Cultured Cells; Cyanoacrylates; Data; Development; Drug Controls; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Elasticity; Engineering; Engineerings; Equipment; Exhibits; Fibrin; Fibrin Adhesive; Fibrin Glue; Fibrin Sealant; Fibrin Sealant System; Fibrin Tissue Adhesive; Fibrinogen Adhesive; Fluorescence; Formulation; Formulations, Drug; Free Radicals; Funding; Gel; Gene Delivery; Gene Expression; Gene Inactivation; Gene Silencing; Genes; Genetic Vectors; Glues; Goals; Healed; Health; Hydrogels; Hysterectomy; Immune response; In Vitro; Incidence; Injury; Investigators; JV15-2; Kinetic; Kinetics; Laceration; Life; Liquid substance; MAD Homolog 3; MADH3; MADH3 gene; MADH3 protein, human; Macrogols; Mammals, Rats; Mechanics; Mercaptans; Mercapto Compounds; Methods; Modeling; Modification; Molecular Weight; Mothers Against Decapentaplegic Homolog 3; Mothers Against Decapentaplegic Homolog 3 Protein; Mothers Against Decapentaplegic, Drosophila, Homolog of, 3; Nature; Nucleic Acids; Operating Rooms; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PEG; Patients; Phase; Plasmids; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polymers; Polyoxyethylenes; Population; Pressure; Pressure- physical agent; Procedures; Property; Property, LOINC Axis 2; QOL; Quality of life; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reaction; Recovery; Relative; Relative (related person); Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Route; SBIR; SBIRS (R43/44); SMA- and MAD-Related Protein 3; SMAD3; SMAD3 Protein; Safety; Scars; Signal Pathway; Small Business Innovation Research; Small Business Innovation Research Grant; Solutions; Spottings; Stretching; Sulfhydryl Compounds; Sun/Ultra-Violet Rays; Surgical; Surgical Interventions; Surgical Procedure; Surgical sutures; Sutures; System; System, LOINC Axis 4; Technology; Therapeutic; Thiols; Time; Tissel; Tissue Adhesives; Tissues; Toxic effect; Toxicities; Transfection; UV radiation; Ultraviolet Rays; United States; Upper arm; Urinary System, Bladder; Urinary System, Urine; Urine; Viral; Woman; Work; base; biocompatibility; biomaterial compatibility; bladder surgery; cohesion; controlled release; copolymer; cross-link; crosslink; design; designing; extracellular; fluid; healing; host response; human MADH3 protein; immunoresponse; implantation; in vivo; injury and repair; innovate; innovation; innovative; knock-down; liquid; mRNA Expression; novel; polymerization; pressure; public health relevance; repair; repaired; shRNA; short hairpin RNA; small hairpin RNA; sulfhydryl group; surgery; tisseel; tissue glueing; transfection vector; trial regimen; trial treatment; ultraviolet light; ultraviolet radiation; urinary bladder; urologic; urological; vector; vector (nucleic acid cloning)",Development of Scar-Inhibiting Compliant Tissue Adhesive,"  In the United States, 1/3 of women can expect to have hysterectomy by age 60 and the most common (incidence of up to 8.3%) complication associated with this procedure is accidental nicking of the bladder during surgery. The main goal of the proposed research is to engineer a novel, biodegradable tissue glue for on-the-spot treatment of surgical bladder injuries. The new glue will not only eliminate the need for stitches, catheters, and collecting bags during recovery, but also release therapeutics to block unwanted scar tissues on the bladder during healing, and thus, will help increase the quality of life of many women.",8785,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",A2,1,214408,
7791757,R21,EB,1,,01/05/2010,12/31/2010,PA-06-181,1R21EB009435-01A1,,NIBIB:253500;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NEW YORK,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"SIGMUND, ERIC EDWARD;",8850423;,1R21EB009435,01/05/2010,12/31/2011,"Algorithms; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Model; Animal Models and Related Studies; Anisotropy; Apoplexy; Area; Artifacts; Attention; Behavior; Body Tissues; Brain; Brain region; Cardiac infarction; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Clinical; Compartment syndromes; Complex; Crossmatching, Tissue; DWI (diffusion weighted imaging); Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Diabetes Mellitus; Diagnostic; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Diffusion weighted imaging; Dysfunction; Encephalon; Encephalons; Ensure; Exertion; Fiber; Functional disorder; Future; Goals; Histocompatibility Testing; Human; Human, General; INFLM; Image; Image Reconstructions; Imaging technology; In Situ; Infarction; Infiltration; Inflammation; Injury; Intracellular Communication and Signaling; Ischemia; Knee; Lesion; MR Imaging; MR Tomography; MRI; MS (Multiple Sclerosis); Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Maps; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Metric; Microscopic; Monitor; Morphologic artifacts; Morphology; Motion; Multiple Sclerosis; Muscle; Muscle Tissue; Muscle function; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Muscular Dystrophies; Musculoskeletal Diseases; Myocardial Infarct; Myocardial Infarction; Myocardium; Myodystrophica; Myodystrophy; NMR Imaging; NMR Tomography; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Noise; Nuclear Magnetic Resonance Imaging; Organ; Organ System; Output; Pathology; Pattern; Phase; Physiologic; Physiologic pulse; Physiological; Physiopathology; Population; Position; Positioning Attribute; Primary Senile Degenerative Dementia; Process; Productivity; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Pulse; Radial; Radiology; Radiology Specialty; Radiology, General; Reconstructions, Image; Relaxation; Resolution; Rotation; Scanning; Scheme; Sclerosis, Disseminated; Series; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Stroke; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Techniques; Testing; Time; Tissue Crossmatchings; Tissue Typing; Tissues; Training; Translating; Translatings; Validation; Vascular Accident, Brain; Work; Zeugmatography; biological signal transduction; biomarker; body system; brain attack; cardiac infarct; cardiac motion; cardiac muscle; cerebral vascular accident; clinical applicability; clinical application; clinical relevance; clinically relevant; coronary attack; coronary infarct; coronary infarction; dementia of the Alzheimer type; design; designing; diabetes; diffusion tensor imaging; experiment; experimental research; experimental study; healthy volunteer; heart attack; heart infarct; heart infarction; heart motion; heart muscle; histocompatibility typing; imaging; improved; in vivo; indexing; infarct; insular sclerosis; kinematics; language translation; model organism; musculoskeletal disorder; musculoskeletal disorder diagnosis; neurodegenerative illness; pathophysiology; patient population; primary degenerative dementia; programs; public health medicine (field); public health relevance; reconstruction; research study; senile dementia of the Alzheimer type; skeletal; stroke; substantia alba; tool; tumor; virtual; white matter",Dynamical DTI: A method for time-resolved in vivo diffusion tensor imaging," NARRATIVE / PROJECT RELEVANCE The relevance of this project to public health lies in its potential to translate a powerful technique of clinical radiology (diffusion tensor imaging) to the regime of dynamic time-resolved imaging. If successful, it promises to impact diagnosis of musculoskeletal disorders (such as muscular dystrophy, chronic exertional compartment syndrome, or diabetes), by tracking microarchitectural status during muscle exertion. Similarly, in the future, the technique may be applicable to the complex motion of the heart and allow the microscopic tissue state to be dynamically monitored in both the healthy state and in the case of infarct.",9435,BMIT,Biomedical Imaging Technology Study Section,A1,1,253500,
7788377,R21,EB,1,,05/01/2010,04/30/2011,PA-06-181,1R21EB009513-01A1,,NIBIB:231627;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,ROCHESTER,UNITED STATES,CHEMISTRY,09,041808262,US,MI,483094401,OAKLAND UNIVERSITY,"ZENG, XIANGQUN ;",7087879;,1R21EB009513,05/01/2010,04/30/2012,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; ABX-EGF; ABX-EGF MAb; ATGN; Agonist; Allergy; Anti-EGFR Monoclonal Antibody; Anti-ERB-2; Anti-Epidermal Growth Factor Receptor Monoclonal Antibody; Anti-HER2/c-erbB2 Monoclonal Antibody; Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Anti-c-ERB-2; Anti-c-erbB2 Monoclonal Antibody; Anti-erbB-2; Anti-erbB2 Monoclonal Antibody; Anti-p185-HER2; Antibodies; Antibody Fragments; Antigens; Articulation; Assay; Atrophic Arthritis; Autoimmune Diseases; Avastin; Bevacizumab (rhuMAb VEGF); Bioassay; Biologic Assays; Biological; Biological Assay; Biotin; Blood Serum; C2B8 Monoclonal Antibody; CYP1B1; Cancers; Cardiovascular Diseases; Cellular Expansion; Cellular Growth; Cetuximab; Clinic; Clinical; Clinical Research; Clinical Study; Collaborations; Coupling; Decision Making; Detection; Development; Diagnostic; Disease; Disorder; Drops; Drugs, Nonproprietary; EDS-4-hydroxylase; Engineering; Engineerings; Ensure; Enzymes; Erbitux; Exhibits; Future; Genentech brand of rituximab; Genentech brand of trastuzumab; Generic Drugs; Graft Rejection; HER2 Monoclonal Antibody; Half-Life; Half-Lifes; Health Care Costs; Health Costs; Healthcare Costs; Herceptin; Hoffman-La Roche brand of trastuzumab; Hoffmann-La Roche brand of rituximab; Human; Human, General; Hypersensitivity; IDEC brand of rituximab; Immune response; Immunoassay; Immunoglobulin Fragments; Immunologist; Industry; Inflammatory Arthritis; Injection of therapeutic agent; Injections; Instrumentation, Other; Investigation; Joints; Killings; Label; Legal patent; Libraries; Life; Link; MAb Therapeutics; MabThera; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Manuscripts; MoAb ABX-EGF; MoAb HER2; MoAb VEGF; Monitor; Monoclonal Antibody ABX-EGF; Monoclonal Antibody Anti-VEGF; One Step; One-Step dentin bonding system; Patents; Patients; Phage Display; Physicians; Process; Protocol; Protocols documentation; Publications; Quartz; Quartz (SiO2); Reagent; Recombinant Antibody; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Recombinants; Research; Rheumatoid Arthritis; RhuMAb VEGF; Rituxan; Rituximab (C2B8 Antibody); Roche brand of rituximab; Roche brand of trastuzumab; Sampling; Scientific Publication; Serum; Specificity; Surface; Technology; Therapeutic; Therapeutic Effect; Therapeutic Monoclonal Antibodies; Therapeutic antibodies; Transducers; Transplant Rejection; Transplantation Rejection; Trastuzumab; Tumor Cell; Vitamin H; Work; assay development; autoimmune disorder; base; bevacizumab; biomarker; c-erb-2 Monoclonal Antibody; cardiovascular disorder; cell growth; coenzyme R; cost; cytochrome P-450 CYP1B1; cytochrome P450 CYP1B1; cytochrome P4501B1; disease/disorder; dosage; estradiol 17-sulfate 4-hydroxylase; estradiol-4-hydroxylase; estrogen 4-hydroxylase; generic; host response; human disease; immunogen; immunogenic; immunoresponse; instrumentation; malignancy; member; neoplasm/cancer; neoplastic cell; panitumumab; point of care; public health relevance; rhuMAb HER2; rhuMabVEGF; rituximab; success",ScFv Piezoimmunosensor Detection of Therapeutic Antibodies in Human Serum," Project narrative  The proposed research will focus on developing scFv recombinant antibodies and scFv-based piezoimmunosensor assays for use in detecting therapeutic antibodies in human serum samples. At present, rapid, simple, highly sensitive, inexpensive assays to detect most of therapeutic antibodies in human serum samples are not readily available. Since the proposed assay will be more sensitive than traditional immunoassay (e.g. ELISAs or whole antibody immunosensors) and can rapidly and accurately detect therapeutic antibodies in humans using a few drops of human serum and inexpensive instrumentation, a physician will be able to quickly determine if the concentration of therapeutic antibody in patients is sufficient or if therapy must be changed to benefit the patient.",9513,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,A1,1,231627,
7772395,R21,EB,1,,02/01/2010,01/31/2011,PA-06-181,1R21EB010126-01,,NIBIB:193125;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"ROESSLER, BLAKE J;",1947669;,1R21EB010126,02/01/2010,01/31/2012,"Amputation; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bone; Bone Infection; Bone and Bones; Bone structure of foot; Bones and Bone Tissue; Characteristics; Charcot foot; Clinical; Complication; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Debridement; Development; Devices; Diabetes Mellitus; Diabetic Foot; Diabetic Foot Ulcer; Diagnosis; Diagnostic; Disease Frequency Surveys; Early Diagnosis; Electromagnetic, Laser; Foot; Foot Bones; Foot Ulcer; Foot Ulcer, Diabetic; Goals; Hand; Human; Human, General; Infection; Lasers; Lead; Light; Man (Taxonomy); Man, Modern; Metatarsal Bones; Metatarsal bone structure; Metatarsals; Methods; Miscellaneous Antibiotic; NIR Spectroscopy; Near-Infrared Spectroscopy; Operation; Operative Procedures; Operative Surgical Procedures; Osteomyelitis; Patients; Pattern; Pb element; Pes; Photoradiation; Radiation, Laser; Raman Spectroscopy; Raman Spectrum Analysis; Raman spectrometry; Sampling; Spectrometry, Near-Infrared; Spectroscopy, IR/UV/Raman; Spectroscopy, Near-Infrared; Spectrum Analysis, Raman; Surface; Surgical; Surgical Interventions; Surgical Procedure; Technology; ULCN; Ulcer; Ulceration; bone; bone quality; cost; detector; diabetes; diabetic; diabetic patient; early detection; foot; foot bone; healthy volunteer; heavy metal Pb; heavy metal lead; improved; in vivo; prototype; public health relevance; surgery",Transcutaneous Raman Spectroscopy for Diagnosis of Diabetic Osteomyelitis, PROJECT NARRATIVE Patients with diabetes frequently get foot ulcers and these ulcers can lead to infection of foot bones. Early diagnosis of infected foot bones would improve treatment. We propose to develop a hand held device that would use laser light to identify infected bone in patients with diabetic foot ulcers.,10126,ZRG1,Special Emphasis Panel,,1,193125,
7771391,R21,ES,1,,02/01/2010,01/31/2011,PA-06-181,1R21ES017813-01,,NIEHS:231750;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,SAN FRANCISCO,UNITED STATES,DENTISTRY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"DEN BESTEN, PAMELA K;",1872179;,1R21ES017813,02/01/2010,01/31/2012,"A Mouse; A/J Mouse; Acquired Dental Fluorosis; Address; Affect; Animals; Anxiety; Applications Grants; Behavior; Behavioral; Blood Serum; Brain; Brain region; Cognitive; Collaborations; Communities; Cross-Over Studies; Cross-Over Trials; Crossover Studies; Crossover Trials; Dental Enamel; Dental Fluorosis, Acquired; Development; Discipline; Dose; Enamel; Encephalon; Encephalons; Ensure; Exhibits; Female; Fluorides; Fluorosis, Dental; Future; Gender; Gene variant; Genetic; Genetic Diversity; Genetic Variation; Goals; Grant Proposals; Grants, Applications; Human; Human, General; Inbred Mouse; Ingestion; Institutes; Institution; Investigation; Lead; Learning; Link; Locomotion; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Memory; Methods; Mice; Mottled Enamel; Mouse Strains; Murine; Mus; NRVS-SYS; Nervous System; Nervous System, Brain; Nervous system structure; Neurochemistry; Neurologic; Neurologic Body System; Neurologic Effect; Neurologic Organ System; Neurological; Oral health; Pb element; Physiologic; Physiological; Physiology; Population; Predisposition; Prevalence; Publishing; Relative; Relative (related person); Relative Risks; Reporting; Risks, Relative; Rodent; Rodentia; Rodentias; School Dentistries; School Dentistry; Science of neurochemistry; Serum; Social Behavior; Susceptibility; System; System, LOINC Axis 4; Testing; Tooth; Tooth Diseases; Tooth Disorder; Tooth structure; Toxic effect; Toxicities; Variation (Genetics); Water Supply; allelic variant; base; behavior test; behavioral test; cost effective; dental disease; dental disorder; dental health; drinking water; experiment; experimental research; experimental study; fluorosis; heavy metal Pb; heavy metal lead; male; molecular marker; mouse model; neurobehavioral; neurochemistry; public health relevance; research study; response; risk benefit ratio; sex; sociobehavior; sociobehavioral; teeth; tooth enamel",Effects of Fluoride on Behavior in Genetically Diverse Mouse Models," PROJECT NARRATIVE Fluoride is important for optimal dental health. However, at higher fluoride concentrations, animal and human studies have suggested neurological effects of fluoride that have been linked to behavioral changes. In this proposal we will expose mice to fluoride in drinking water that results in physiologically relevant serum fluoride concentrations, to determine the effects of fluoride on behavior relative to dose, sex, and strain of mouse.",17813,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,1,231750,
7773778,R21,EY,1,,02/01/2010,01/31/2011,PA-06-181,1R21EY019977-01,,NEI:217500;,2010,NATIONAL EYE INSTITUTE,,FORT WORTH,UNITED STATES,ANATOMY/CELL BIOLOGY,12,110091808,US,TX,761072699,UNIVERSITY OF NORTH TEXAS HLTH SCI CTR,"CLARK, ABBOT FREDERICK;",8688641;,1R21EY019977,02/01/2010,01/31/2012,"Address; Animal Model; Animal Models and Related Studies; Anterior; Aqueous Humor; Back; Blindness; Body Tissues; Cranial Nerve II; Cranial Nerve II Diseases; Cranial Nerve II Disorder; DISSEC; Development; Disease; Disorder; Disorder of the optic nerve; Dissection; Dorsum; Eye; Eyeball; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glaucoma; Human; Human, General; Intraocular Fluid; Intraocular Pressure; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mice; Modeling; Molecular; Mouse Strains; Murine; Mus; Mutation; Neural-Optical Lesion; Ocular Hypertension; Ocular Tension; Optic Nerve; Optic Nerve Diseases; Optic Neuropathy; POAG; Partial Sight; Pathway interactions; Patients; Perfusion; Physiologic Intraocular Pressure; Pressure; Pressure- physical agent; Primary Open Angle Glaucoma; Process; Retinal Diseases; Retinal Disorder; Risk Factors; Rodent; Rodentia; Rodentias; Second Cranial Nerve; Second Cranial Nerve Diseases; Sight; Survey Instrument; Surveys; Testing; Therapeutic; Time; Tissues; Trabecular Meshwork; Trabecular meshwork structure; Transgenes; United States; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual impairment; cytokine; disease/disorder; genome mutation; glaucomatous; model organism; mouse model; mutant; myocilin; novel therapeutic intervention; ocular hypertensive; optic nerve disorder; pathway; pressure; public health relevance; retina disease; retina disorder; retinopathy; second cranial nerve disorder; visually impaired",A New Model of Human Primary Open-Angle Glaucoma,,19977,AED,Anterior Eye Disease Study Section,,1,217500,
7788497,R21,HD,1,,01/20/2010,12/31/2010,PA-06-181,1R21HD059043-01A2,,NICHD:246745;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,DENVER,UNITED STATES,,01,076443019,US,CO,80206,NATIONAL JEWISH HEALTH,"KLINNERT, MARY D.;",1885942;,1R21HD059043,01/20/2010,12/31/2011,"0-11 years old; Accounting; Address; Affect; Allergic; Allergic Reaction; Allergy; Allergy, Food; American; Anxiety; Asthma; Attention; Behavior; Bronchial Asthma; Child; Child Youth; Childhood; Children (0-21); Country; Development; Distress; Equilibrium; European; Family; Family Study; Fear; Food; Food Hypersensitivity; Frequencies (time pattern); Frequency; Fright; Goals; Human, Child; Hypersensitivity; Intervention; Intervention Strategies; Interview; Lead; Life; Measures; Parents; Pattern; Pb element; Preparation; Prevalence; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Reaction; Research; Safety; Schools; Services; Stress; System; System, LOINC Axis 4; balance; balance function; base; children; coping; design; designing; experience; family management; heavy metal Pb; heavy metal lead; instrument; intervention development; interventional strategy; pediatric; programs; psychosocial; public health relevance; service intervention; therapy development; tool; treatment development; vigilance; youngster",Children's Food Allergies:  Assessing Family Management and Adaptation," PUBLIC HEALTH RELEVANCE Food allergies have increased dramatically in prevalence in the past decade. The public media has drawn attention to the severe impact on families of food allergic children due to the strains of daily management and the anxiety and distress that results from constant vigilance and fear of life-threatening reactions. Attention has also turned to the needs of food-allergic children in the public school setting, where both affected and unaffected children are impacted. The goal of this study is to develop an interview-based measure of families' food allergy management and adaptation. With this tool it will be possible to evaluate families' adaptation to their children's food allergies, to determine how many families have significant distress or difficulty managing, and to develop services for families with difficulties in coping.",59043,PDRP,"Psychosocial Development, Risk and Prevention Study Section",A2,1,246745,
7796521,R21,HD,1,,01/13/2010,12/31/2010,PAR-08-135,1R21HD060978-01A1,,NICHD:160500;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,HOUSTON,UNITED STATES,NEUROLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"SAVITZ, SEAN I;",8953831;,1R21HD060978,01/13/2010,12/31/2011,"21+ years old; ARDS; ARDS, Human; ARDSs, Human; Acquired brain injury; Acute; Acute Liver Failure; Acute myocardial infarct; Acute myocardial infarction; Adult; Adult RDS; Adult Respiratory Distress Syndrome; Adverse Experience; Adverse event; Animals; Apoplexy; Autograft; Autologous; Autologous Transplantation; Autotransplant; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Brain; Brain Injuries; Brain Mass; Cell Therapy; Cell Transplantation; Cells; Cerebral Stroke; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Clinical Research; Clinical Study; Conduct Clinical Trials; Craniocerebral Trauma; DWI (diffusion weighted imaging); Data; Diffusion weighted imaging; Dose; Drip Infusions; Drip, Intravenous; Encephalon; Encephalons; Enrollment; Evaluation; Exploratory/Developmental Grant; Fulminating Hepatic Failure; Fulminating Liver Failure; Funding; Gait; Grant; HOSP; Harvest; Head Injuries; Head Trauma; Hepatic; Hepatic Failure; Hepatic Failure, Acute; Hepatic Failure, Fulminant; Hospital safety; Hospitalization; Hospitals; Human; Human, Adult; Human, General; INFLM; IV Infusion; IV drip; Image; Infarction; Infection; Inflammation; Infusion; Infusion procedures; Infusions, Intravenous; Injection of therapeutic agent; Injections; Injuries, Craniocerebral; Injury; Institution; Intravenous; Intravenous Drip; Intravenous Infusion; Intravenous infusion procedures; Ischemic Heart; Ischemic Heart Disease; Ischemic Stroke; Ischemic myocardium; Laboratories; Laboratory Study; Liver Failure; Liver Failure, Acute; Liver Failure, Fulminant; Lung; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Minority; Modality; Modeling; Monitor; Mononuclear; Myocardial Ischemia; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Nature; Nervous System, Brain; Neurologic; Neurological; Nuclear Magnetic Resonance Imaging; Organ System; Outcome; Outcome Measure; Patients; Population; Public Health; R21 Mechanism; R21 Program; Recovery; Research Design; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Risk; Rodent; Rodent Model; Rodentia; Rodentias; Safety; Seizures; Series; Severe Adverse Event; Shock Lung; Stroke; Strokes, Acute; Study Type; Symptoms; Testing; Therapeutic; Therapy, Cell; Time; Tissues; Toxic effect; Toxicities; Transplantation; Transplantation, Autologous; United States National Institutes of Health; Vascular Accident, Brain; Work; Zeugmatography; acute stroke; adult human (21+); body system; brain attack; brain damage; brain lesion (from injury); cell-based therapy; cerebral vascular accident; design; designing; disability; drip infusion; effective therapy; enroll; experience; experiment; experimental research; experimental study; fulminant hepatic failure; functional outcomes; heart ischemia; imaging; improved; indexing; infarct; interest; intravenous administration; myocardial ischemia/hypoxia; myocardium ischemia; neurorestoration; neurorestorative; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; patient population; phase 1 study; public health medicine (field); public health relevance; pulmonary; repair; repaired; research study; safety study; stroke; stroke recovery; study design; transplant; vein infusion",Safety/Feasibility of Autologous Mononuclear Bone Marrow Cells in Stroke Patients, Stroke is the leading cause of adult disability but there are few effective therapies for this devastating condition. Cell therapy is a promising new approach to enhance recovery from stroke. This application proposes to assess the safety and feasibility of autologous bone marrow mononuclear cells in stroke patients. The data from these proposed experiments are essential to begin developing this new therapeutic approach to enhance recovery from stroke.,60978,ANIE,Acute Neural Injury and Epilepsy Study Section,A1,1,160500,
7772082,R21,HD,1,,02/01/2010,01/31/2011,PA-06-181,1R21HD062853-01,,NICHD:192500;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BLOOMINGTON,UNITED STATES,CHEMISTRY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"DANN, CHRISTINA TENENHAUS;",9643257;,1R21HD062853,02/01/2010,01/31/2012,"Address; Adeno-Associated Viruses; Antibiotic Resistance; Assay; Autograft; Autologous Transplantation; Autotransplant; Bioassay; Biologic Assays; Biological Assay; Biopsy; Breeding; Cell Cycle; Cell Cycle Stage; Cell Differentiation; Cell Differentiation process; Cell Division Cycle; Cell Line; Cell Lines, Strains; Cell Transplants; CellLine; Cells; DNA; DNA Binding Domain; Deoxyribonucleic Acid; Dependovirus; Development; Disease; Disorder; ES cell; Embryo; Embryonic; Engineering; Engineerings; Event; Fertility/Fertilization; Fertilization; Fluorescence; GFP; Gametes; Gene Delivery; Gene Targeting; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Intervention; Genetic defect; Genital System, Male, Testis; Germ Cells; Germ-Line Cells; Goals; Green Fluorescent Proteins; Hereditary Disease; Human; Human, General; In Vitro; Intervention, Genetic; Knock-in; Knock-in Mouse; Lentiviral Vector; Lentivirus Vector; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods; Mice; Modeling; Modification; Molecular; Molecular Biology, Gene Therapy; Molecular Disease; Mother Cells; Murine; Mus; Mutate; Mutation; Oncogene Activation; Oncogenesis; Organism; Patients; Process; Processed Genes; Progenitor Cell Transplantation; Progenitor Cells; Protein Motifs, DNA-Binding; Proteins; Reproductive Cells; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Route; Sex Cell; Site; Somatic Cell; Source; Stem Cell Transplantation; Stem cell transplant; Stem cells; Targetings, Gene; Testicles; Testing; Testis; Therapeutic; Therapy, DNA; Transgenes; Transgenic Organisms; Transmission; Transplantation; Transplantation, Autologous; Transplants, Cell; Validation; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adeno associated virus group; antibiotic resistant; base; cDNA Expression; cell type; clinical relevance; clinically relevant; cultured cell line; disease/disorder; embryonic stem cell; gene correction; gene product; gene therapy; gene-corrected; genetic disorder; genetic therapy; genome mutation; hereditary disorder; homologous recombination; initial cell; interest; living system; men; men's; mouse model; mutant; next generation; nuclease; protein expression; public health relevance; repair; repaired; self-renewal; sexual cell; stem; stem cell differentiation; stem cell of embryonic origin; success; technology development; theories; tool; transgenic; transmission process; transplant; tumorigenesis",Gene therapy using homologous recombination in mouse spermatogonial stem cells," PUBLIC HEALTH RELEVANCE STATEMENT/NARRATIVE Correcting a mutated gene in stem cells and transplanting the corrected stem cells into a patient could be an effective way to cure certain genetic diseases. A promising new method to correct mutant genes is to cut the gene using molecular scissors (zinc finger nucleases), a process that then stimulates the exchange of the mutated gene sequence with an exogenously provided normal gene sequence. We propose to test and optimize this process of gene correction in cultured spermatogonial stem cells, cells with great therapeutic potential and that are highly related to pluripotent embryonic stem cells.  ",62853,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,1,192500,
7770965,R21,HD,1,,02/01/2010,01/31/2011,PA-06-181,1R21HD062859-01,,NICHD:255743;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,AMHERST,UNITED STATES,,01,153926712,US,MA,010039242,UNIVERSITY OF MASSACHUSETTS AMHERST,"SCHNEYER, ALAN L;",1862034;,1R21HD062859,02/01/2010,01/31/2012,"21+ years old; Activin-Binding Protein; Activins; Adult; Age; Aged 65 and Over; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Biochemical; Biological; Birth; Breeding; Cannot achieve a pregnancy; Causality; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Proliferation; Change of Life, Female; Cyst; Defect; Development; Difficulty conceiving; Disease; Disorder; Dysfunction; Elderly; Elderly, over 65; Embryo; Embryonic; Etiology; FLR; FSH-Releasing Protein; Failure (biologic function); Fecundability; Fecundity; Female; Fertility; Fertility Disorders; Fertility/Fertilization; Fertilization; Follistatin; Foundations; Frequencies (time pattern); Frequency; Functional disorder; Future; Gametes; Generalized Growth; Genes; Genital System, Female, Ovary; Germ Cells; Germ-Line Cells; Goals; Growing Follicle; Growth; Human; Human, Adult; Human, General; Infertility; Isoforms; Lead; Left; Litter Size; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Meiosis; Menopause; Mice; Murine; Mus; Neonatal; Oocytes; Ovarian; Ovarian Failure, Premature; Ovary; Ovocytes; Parturition; Patients; Pb element; Physiopathology; Premature Ovarian Failure; Primordial Follicle; Process; Property; Property, LOINC Axis 2; Protein Isoforms; Regulation; Reproductive Cells; Reproductive Periods; Research; Rest; Role; Sex Cell; Site; Staining method; Stainings; Stains; Superovulation; Syndrome; Technology; Testing; Time; Tissue Growth; Transgenic Organisms; adult human (21+); advanced age; analog; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; egg; elders; exhaust; failure; geriatric; granulosa cell; heavy metal Pb; heavy metal lead; infertile; initial cell; late life; later life; meiotic; member; menopausal; model organism; mouse model; neonate; older adult; older person; ontogeny; pathophysiology; premature; public health relevance; reproductive; senior citizen; sexual cell; social role; transgenic; unable to bear children",Regulation Of Follicle Development and Fertility By Activin and Follistatin," Project Narrative: The number of eggs that female animals and humans are born with is their entire stock for their reproductive lifetime. When this stock is depleted, the ovary stops maturing new eggs, a process known as menopause in humans. In some fertility disorders, this process occurs earlier than expected, shortening the reproductive period for these patients and leaving them with few treatment options. The research in this proposal will investigate the role of activin and follistatin in regulating both the number of eggs, and the process of maturation, which could help define the defects that lead to early menopause, and to new treatments for this disorder.",62859,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,1,255743,
7774526,R21,HD,1,,02/01/2010,01/31/2011,PA-06-181,1R21HD062951-01,,NICHD:229500;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,IRVINE,UNITED STATES,BIOCHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"YOKOMORI, KYOKO ;",2796248;,1R21HD062951,02/01/2010,01/31/2012,"Address; Affect; Amsterdam type; BMH; Binding; Binding (Molecular Function); Binding Sites; Biological Models; Brachmann-Cornelia de Lange (BCDL) syndrome (BDLS); Brachmann-Cornelia de Lange syndrome; Brachmann-De Lange Syndrome; Bruck-de Lange syndrome; CHIP assay; CSPG6; CSPG6 gene; Candidate Disease Gene; Candidate Gene; Cell Cycle; Cell Division Cycle; Cell Nucleus; Cell division; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromosomal Organization; Chromosomal Structure; Chromosome Organization; Chromosome Segregation; Chromosome Structures; Combining Site; Complex; Cornelia De Lange Syndrome; Cornelia de Lange (CDL) syndrome (CLS) 1; Cornelia de Lange 1; Cornelia de Lange syndrome (CLS) 2; Cornelia de Lange syndrome 2; DNA Double Strand Break; Data; De Lange Syndrome; Developmental Gene; Disease; Disorder; Distal; Distant; Drosophila; Drosophila genus; Enhancers; Event; Fruit Fly, Drosophila; Future; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Gene, Developmental; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genome; Globin; Goals; HCAP; Hereditary; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Homologous Recombinational Repair; Inherited; Interphase; Investigation; Lange syndrome 1 Amsterdam dwarf; Lange syndrome 2; Lead; Link; M Phase; M phase (cell cycle); Maintenance; Maintenances; Mammalian Cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Mutant Strains; Mitosis; Mitosis Stage; Mitotic Chromosome; Model System; Models, Biologic; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutant Strains Mice; Mutation; Nucleus; Outcome Study; Pathogenesis; Patients; Pb element; Phenotype; Plant Roots; Play; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); RNA Expression; Racial Segregation; Reactive Site; Recombination Repair; Regulation; Role; SMC3; SMC3L1; Sister Chromatid; Study, Outcome; Targetings, Gene; Testing; Tissue Sample; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Typus Degenerativus Amstelodamensis; Yeasts; chromatin immunoprecipitation; cohesin; cohesion; conformation; conformational state; congenital muscular hypertrophy-cerebral syndrome; de Lange syndrome 1; de Lange syndrome 2; developmental disease/disorder; developmental disorder; disease-causing mutation; disease/disorder; fruit fly; genetic promoter element; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; homologous recombination; human disease; imprint; in vivo; insight; mouse model; mouse mutant; novel; p-Globin; protein complex; public health relevance; recombinational repair; root; segregation; social role; status degenerativus amstelodamensis; therapeutic development; transcription factor; typus amstelodamensis",Role of Cohesin in Developmental Gene Regulation," Project Narrative Cornelia de Lange syndrome (CdLS) is a dominantly-inherited multisystem developmental disorder whose underlying pathogenic mechanism remains unclear. Since most CdLS cases result from mutations of factors related to cohesin, it is essential to understand cohesin's role in this disease's pathogenesis. In the proposed project, we plan to test the hypothesis that the disease is caused by dysregulation of target genes that are directly controlled by cohesin and to address the molecular mechanism of cohesin-mediated gene regulation. The outcome of this study should provide new insight into the molecular events at the root of CdLS, which may lead to the possible development of therapeutic strategies.",62951,GHD,Genetics of Health and Disease Study Section,,1,229500,
7773394,R21,HD,1,,02/01/2010,01/31/2011,PA-06-181,1R21HD062952-01,,NICHD:236250;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PHILADELPHIA,UNITED STATES,ANATOMY/CELL BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MULLINS, MARY C;",1904461;,1R21HD062952,02/01/2010,01/31/2012,"Aberrant Chromosome; Abnormalities, Chromosomal; Anaphase; Animal Model; Animal Models and Related Studies; Animals; Architecture; Biological Function; Biological Process; Blastocyst; Blastocyst structure; Blastocytes; Blastomere; Blastomeres; Blastosphere; Brachydanio rerio; Causality; Cell Culture Techniques; Cell Cycle; Cell Division Cycle; Cell Nucleus; Cell division; Cell division phases; Cells; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Chromosomes; Cytogenetic Aberrations; Cytogenetic Abnormalities; Danio rerio; Defect; Development; Disease; Disorder; Electron Microscopy; Embryo; Embryo Development; Embryo stage 2; Embryo, Preimplantation; Embryogenesis; Embryonic; Embryonic Cell; Embryonic Development; Engineering / Architecture; Ensure; Etiology; Exhibits; Fertilization in Vitro; Fertilized Egg; Fertilized Ovums; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Genome; Human; Human, General; IVF; Injection of therapeutic agent; Injections; Kinesin; M Phase; M phase (cell cycle); MAP; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Mutant Strains; Microscopy; Microtubule-Associated Proteins; Mitosis; Mitosis Stage; Mitotic Anaphase; Mitotic spindle; Molecular; Mothers; Murine; Mus; Mutant Strains Mice; Nature; Nuclear; Nuclear Envelope; Nuclear Membrane; Nucleus; Ovum, Fertilized; Phase; Phenotype; Play; Prevention; Process; Proteins; RNA Expression; Regulation; Reliance; Reporting; Reproductive Technology; Role; Sperm; Spermatozoa; Staging; Structure of blastomere; Structure of embryo stage 2; Structure of zygote; Technology, Reproductive; Test-Tube Fertilization; Testing; Time; Transcription; Transcription, Genetic; Zebra Danio; Zebra Fish; Zebrafish; Zygote; base; blastocyst; blastomere structure; blastula; chromokinesin; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; egg; embryo stage 2; experimental analysis; gene product; implantation; in vivo; in vivo Model; loss of function; micronucleus; model organism; mouse mutant; mutant; public health relevance; reproductive; social role; sperm cell; telophase; tool; zoosperm; zygote",Nuclear architecture and chromosomal dynamics in cleavage stage of development," The proposed studies are particularly relevant to understanding human reproductive disorders and the development of effective reproductive technology, since about 15% of good quality monospermic human embryos produced by in vitro fertilization or intra cytoplasmic sperm injection display multinucleated blastomeres at the 2- to 8-cell stage. Analysis of such blastomeres has shown that chromosomal abnormalities are a frequent occurrence and as such, these embryos are not advised for use in implantation. Understanding the etiology and molecular basis of multi-micronucleation during early embryonic cell division stages in model organisms will provide important parameters and tools to limit multinucleation in human embryos.",62952,DEV2,Development - 2 Study Section,,1,236250,
7774587,R21,HG,1,,02/01/2010,01/31/2011,PA-06-181,1R21HG005252-01,,NHGRI:218414;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"IDEKER, TREY ;PILLUS, LORRAINE  (contact);",1901356 (contact);7040047;,1R21HG005252,02/01/2010,01/31/2012,"Activation, Gene; Address; Affect; Aging; Antibodies; Assay; Aves; Avian; Behavior; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biomedical Research; Birds; Cancer Induction; Cancers; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromosomes; Custom; DNA Binding; DNA Binding Interaction; DNA Damage Repair; DNA Methylation; DNA Repair; DNA-Binding Proteins; Data; Defect; Development; Differential Gene Expression; Diploid; Diploidy; Disease; Disorder; Elements; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Frequencies (time pattern); Frequency; Funding; Future; Gene Action Regulation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Proteins; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Transcription; Genes; Genetic; Genetic Markers; Genetic Transcription; Genomics; Goals; Grouping; Health; Histones; Human; Human, General; Immune Precipitation; Immunoprecipitation; Individual; Instruction; International; Investigators; Knock-out; Knockout; Libraries; Location; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Measurement; Measures; Methods; Microarray Analysis; Microarray-Based Analysis; Modification; Molecular; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pathology; Pattern; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Gene Products; RNA Expression; RT-PCR; RTPCR; Regulation; Research; Research Personnel; Research Resources; Researchers; Resources; Reverse Transcriptase Polymerase Chain Reaction; Reverse Transcription; Senescence; Subcellular Process; Syndrome; Technology; Testing; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Transcription; Transcription, Genetic; United States National Institutes of Health; Unscheduled DNA Synthesis; Variant; Variation; Yeasts; base; carcinogenesis; deletion library; disease phenotype; disease/disorder; epigenomics; experiment; experimental research; experimental study; functional genomics; genome-wide; groupings; histone modification; homologous recombination; interest; malignancy; microarray technology; microchip; neoplasm/cancer; programs; public health relevance; research study; reverse transcriptase PCR; senescent; stem; technology development; transcription factor",Massively parallel epigenomics: building new value with current resources," PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Epigenetics contribute to critical cellular functions and pathologies ranging from gene silencing and DNA repair to tissue-specific gene expression, cell differentiation, carcinogenesis, and aging. Throughout development, differentiating cells accumulate epigenetic instructions that ultimately determine fully differentiated patterns of expression. Many developmental syndromes, and specific disease phenotypes, including cancer, stem from fundamental epigenetic changes that inactivate critical genes or activate disruptive genes. Identifying disease- causing epigenetic changes and finding ways to mitigate, alter, or reverse deleterious ones will be the subject of biomedical research for the foreseeable future. Combining reference epigenome maps with TF-epigenome interaction measurements, as proposed in this study, will enable researchers to specifically pinpoint epigenetic changes that induce altered TF binding behavior and contribute to developmental defects and disease.  ",5252,GCAT,"Genomics, Computational Biology and Technology Study Section",,1,218414,
7787228,R21,HL,1,,02/01/2010,11/30/2010,PA-06-181,1R21HL084239-01A1,,NHLBI:191875;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,GENETICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"CRAIGEN, WILLIAM JAMES;",1930372;,1R21HL084239,02/01/2010,11/30/2011,"0-11 years old; 21+ years old; Adult; Affect; Animal Model; Animal Models and Related Studies; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Function; Biological Models; Biological Process; Biology; Body Tissues; Candidate Disease Gene; Candidate Gene; Cardiomyopathies; Cardiovascular Diseases; Cataloging; Catalogs; Cell Culture Techniques; Cell Death; Cell Line; Cell Lines, Strains; CellLine; Cells; Child; Child Youth; Childhood; Children (0-21); Clinical; Coloring Agents; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Development; Disease; Disorder; Double-Stranded RNA; Drugs; Dyes; Dysfunction; ES cell; Embryo; Embryonic; Epidemiology; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; Functional disorder; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Research; Genetic Screening; Genetic Susceptibility; Genetic defect; Genetics-Mutagenesis; Genomics; Goals; Human; Human, Adult; Human, Child; Human, General; Individual; Inherited Predisposition; Inherited Susceptibility; Lead; Lentivirinae; Lentivirus; Libraries; Maintenance; Maintenances; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Membrane Potentials; Mental Retardation; Methods; Mice; Mining; Minings; Minority; Mitochondria; Mitochondrial Diseases; Mitochondrial Disorders; Mitochondrial Encephalomyopathies; Mitochondrial Proteins; Model System; Models, Biologic; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Nuclear; Organ; Pathogenesis; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiopathology; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevalence; Process; Proteins; Proteomics; Publishing; Quelling; RNA Interference; RNA Interference Pathway; RNA Silencing; RNA Silencings; RNA polymerase III transcription; RNA, Double-Stranded; RNAi; Respiratory Chain; Resting Potentials; Retroviral Vector; Retrovirus Vector; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Services; Sortings, Fluorescence-Activated Cell; Structure; Subfamily lentivirinae; System; System, LOINC Axis 4; Tissues; Transcript; Transmembrane Potentials; Virus-Lenti; Whole Organism; adult human (21+); anticancer research; base; cancer research; cardiovascular disorder; children; clinical data repository; clinical data warehouse; cultured cell line; data repository; design; designing; disease/disorder; drug/agent; dsRNA; effective therapy; embryonic stem cell; flexibility; gene product; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; human disease; in vivo Model; innovate; innovation; innovative; insight; knock-down; mitochondrial; mitochondrial disease/disorder; mitochondrial dysfunction; mitochondrial membrane; model organism; mutant; myocardium disorder; necrocytosis; new approaches; novel; novel approaches; novel strategies; novel strategy; pathophysiology; pathway; pediatric; public health relevance; relational database; retroviral-mediated; screening; screenings; shRNA; short hairpin RNA; small hairpin RNA; stem; stem cell of embryonic origin; therapeutic target; tool; vector; youngster",A novel recessive genetic screen for mitochondrial phenotypes in mammalian cells, Mitochondria are the structures found in cells that generate energy and regulate cell death. This proposal is to generate cell lines and animal models where specific genes that have some mitochondria functions are disrupted by novel genetic research tools.,84239,ZRG1,Special Emphasis Panel,A1,1,191875,
7788973,R21,HL,1,,01/04/2010,11/30/2010,PA-06-181,1R21HL092799-01A2,,NHLBI:231000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"MATHER, KIEREN J;",6957054;,1R21HL092799,01/04/2010,11/30/2011,"Acute; Animals; B9 endocrine pancreas; Cardiac; Cardiac Diseases; Cardiac Disorders; Cause of Death; Chemotherapy-Hormones/Steroids; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; D-Glucose; Data; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dose; Endocrine Gland Secretion; Evaluation; Fasting; Fatty Acids; GLP-1; Glucose; Heart; Heart Diseases; Hormones; Human; Human, General; Impairment; In Vitro; Infusion; Infusion procedures; Insulin Resistance; Intermediary Metabolism; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Islands of Langerhans; Islet Cells; Islets of Langerhans; Knowledge; Literature; METBL; MODY; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Medical Imaging, Positron Emission Tomography; Metabolic; Metabolic Processes; Metabolism; Myocardial; Myocardial Ischemia; Myocardial perfusion; NIDDM; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; O element; O2 element; Obesity; Organ; Oxygen; PET; PET Scan; PET imaging; PETSCAN; PETT; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Patients; Peptides; Position; Positioning Attribute; Positron Emission Tomography Scan; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopic Imaging; Publishing; Rad.-PET; Reporting; Research Design; Resistance; Saline; Saline Solution; Source; Study Type; T2D; T2DM; Tag; Therapeutic; Therapeutic Hormone; Tracer; Type 2 diabetes; Type II diabetes; adiposity; adult onset diabetes; base; beta cell development; cardiac metabolism; clinical investigation; corpulence; corpulency; corpulentia; diabetes; diabetic; endocrine pancreas; endocrine pancreas development; experience; fasted; fasts; glucagon like peptide; glucagon-like peptide; glucagon-like peptide 1; glucose metabolism; glucose uptake; heart disorder; heart ischemia; heart metabolism; improved; in vivo; insulin resistant; islet development; islet progenitor; ketosis resistant diabetes; maturity onset diabetes; myocardial ischemia/hypoxia; myocardium ischemia; new approaches; new therapeutics; next generation therapeutics; non-diabetic; nondiabetic; novel approaches; novel strategies; novel strategy; novel therapeutics; obese; obese people; obese person; obese population; oxidation; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; public health relevance; resistant; response; study design; tool",Modulation of Human Myocardial Metabolism by GLP-1," The proposed studies are necessary to quantify and better understand the effects of GLP-1 on myocardial metabolism in humans with and without type 2 diabetes. This will allow rational dose selection for further clinical studies evaluating the use of GLP-1 in the management of acute myocardial ischemia, which may be of particular benefit for people with diabetes ",92799,ZRG1,Special Emphasis Panel,A2,1,231000,
7789672,R21,HL,1,,01/12/2010,11/30/2010,PA-06-181,1R21HL093383-01A1,,NHLBI:232650;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HERSHEY,UNITED STATES,NEUROSCIENCES,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"TANG, XIAORUI ;",8443818;,1R21HL093383,01/12/2010,11/30/2011,"Address; Adverse drug effect; Affect; Algorithms; American; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; BP control; Baroreceptors; Baroreflex; Bilateral; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; Blood Vessels; Body Tissues; Brain; Brain Stem; Brainstem; Canine Species; Canis familiaris; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Carotid Sinus; Cell Communication and Signaling; Cell Signaling; Clinical; Common Rat Strains; Devices; Diet; Dogs; Dorsomedial Nucleus; Dorsomedial Nucleus of the Thalamus; Dorsomedial Thalamic Nucleus; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Side Effects; Drug Therapy; Drug resistance; Drugs; Electric Stimulation; Electrical Stimulation; Electrodes; Encephalon; Encephalons; Energy Supply; Exercise; Exercise, Physical; Fats; Fatty acid glycerol esters; Frequencies (time pattern); Frequency; Goals; High Prevalence; Hour; Hypertension; Hypotension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Implant; Intracellular Communication and Signaling; Lateral; Long-Term Potentiation; Mammals, Dogs; Mammals, Rats; Medial Dorsal Nucleus; Medication; Mediodorsal Nucleus; Mediodorsal Thalamic Nucleus; Methods; Modeling; Multi-Drug Resistance; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Multidrug Resistance; Nerve; Nervous; Nervous System, Brain; Nucleus Tractus Solitarii; Nucleus solitarius; Obesity; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Pressoreceptors; Pressure; Pressure- physical agent; Procedures; Protocol; Protocols documentation; Publishing; Rat; Rattus; Receptor Protein; Recovery; Reflex, Baroreceptor; Regimen; Regulation; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Science of neurophysiology; Signal Transduction; Signal Transduction Systems; Signaling; Solitary Nucleus; Stretch Receptors, Arterial; Stretch Receptors, Vascular; Structure of carotid sinus; Supply, Energy; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Tetanus; Time; Tissues; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vascular, Heart; adiposity; base; biological signal transduction; biomedical implant; blood pressure control; blood pressure homeostasis; blood pressure regulation; canine; carotid sinus; circulatory system; clinical significance; clinically significant; clostridial tetanus; computerized data processing; corpulence; corpulency; corpulentia; data processing; domestic dog; drug resistant; drug/agent; effective therapy; experiment; experimental research; experimental study; hyperpiesia; hyperpiesis; hypertension control; hypertensive disease; implant device; implantable device; indwelling device; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; multi-drug resistant; multidrug resistant; neurophysiology; non-drug; normotensive; obese; obese people; obese person; obese population; pathway; pressure; public health relevance; receptor; research study; resistance to Drug; resistant to Drug; response; sensor; signal processing; solitary tract nucleus; surgery; vascular",Antihypertensive Effects of Tetanic Baraoreceptor Input Stimulation, Project Narrative 50 million Americans suffer from high blood pressure; the proposed experiments investigate the effects of brief high frequency (tetanic) stimulation of the carotid sinus nerve on a long lasting blood pressure reduction in normotensive and hypertensive dogs. Positive results could open entirely new avenues for developing more efficient hypertension therapies; and provide an effective treatment for the many patients suffering from drug resistant hypertension.,93383,HM,Hypertension and Microcirculation Study Section,A1,1,232650,
7769809,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL093568-01A2,,NHLBI:228017;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUGHTON,UNITED STATES,ENGINEERING (ALL TYPES),01,065453268,US,MI,499311295,MICHIGAN TECHNOLOGICAL UNIVERSITY,"GOLDMAN, JEREMY ;",8290731;,1R21HL093568,01/15/2010,12/31/2011,"Arm; Axillary Lymph Node Dissection; Body Tissues; C protein; CBP protein (citrate-binding); Cancer of Breast; Capillaries, Lymphatic; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell-Extracellular Matrix; Cells; Cellular Migration; Cellular Proliferation; Data; Disease; Disorder; Drainage; Drainage procedure; ECM; Endothelial Cells, Lymphatic; Extracellular Matrix; FLT4 Ligand; FLT4-L; GFAC; Generalized Growth; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; Implant; Liquid substance; Lymph; Lymphangiogeneses; Lymphangiogenesis; Lymphatic; Lymphatic Capillaries; Lymphatic Endothelial Cells; Lymphedema; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Motility; Motility, Cellular; Murine; Mus; Natural regeneration; Obstruction; Physiologic; Physiological; Regeneration; Regulation; Relative; Relative (related person); Reporting; Resolution; Reticuloendothelial System, Lymph; Role; Scheme; Site; Skin; Staging; Swelling; Tail; Testing; Tissue Growth; Tissues; Upper arm; VEGF-C; VEGFC; VEGFs; VRP; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor Related Protein; Vascular Endothelial Growth Factors; Vegf; angiogenesis; axillary dissection; cancer surgery; cell motility; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; clinical significance; clinically significant; compare effectiveness; disease/disorder; fluid; improved; interstitial; liquid; lymphatic fluid; malignant breast neoplasm; mouse model; ontogeny; overexpression; public health relevance; regenerate; scaffold; scaffolding; social role; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; wound",The Regulation of Interstitial Flow in Experimental Lymphedema by Compression," Lymphedema often follows axillary lymph node dissection from breast cancer surgery. Although compression therapy reduces lymphedema, the mechanism of action is not clear. We aim to clarify the role of compression in regulating interstitial flow and to determine the ability of combined compression/lymphangiogenesis therapy to improve lymphedema.",93568,HM,Hypertension and Microcirculation Study Section,A2,1,228017,
7787295,R21,HL,1,,01/04/2010,11/30/2010,PA-06-181,1R21HL094807-01A1,,NHLBI:188125;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"MEYER, MARKUS ;",9352690;,1R21HL094807,01/04/2010,11/30/2011,"1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy)-, tetrasodium salt; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Acetylcysteine; Acetylin; Acute; Airbron; Allen & Hanburys Brand of Acetylcysteine; Analysis, Area; Animal Model; Animal Models and Related Studies; Animals; Anterior; Anterior Descending Coronary Artery; Antioxidants; Apoptosis; Apoptosis Pathway; Area; Area Analyses; Arrhythmia; Arteries; Azovan Blue; Blood Serum; Body Tissues; Bolus; Bolus Infusion; Bristol-Myers Squibb Brand of Acetylcysteine; Bristol-Myers Squibb Brand of Acetylcysteine Sodium Salt; Broncholysin; Brunac; CREA; Cardiac; Cardiac Arrhythmia; Cardiac Catheterization Procedures; Cardiac Function Study; Cardiac infarction; Cardioscopes; Catheterization, Cardiac; Cell Death, Programmed; Clinical; Clinical Trials; Clinical Trials, Unspecified; Closure by Ligation; Complication; Contrast Agent; Contrast Drugs; Contrast Media; Coronary Disease; Coronary Function Study; Coronary heart disease; Creatinine; Detection; Dysfunction; Evaluation; Evans Blue; Evans blue stain; Fabrol; Family suidae; Fluatox; Fluimucetin; Fluimucil; Fluprowit; Foundations; Functional disorder; Goals; Heart; Heart Arrhythmias; Heart Catheterization; Heart Catheterization Pocedure; Heart Function Study; Heart Muscle tissue; Hour; Human; Human, General; In Situ Nick-End Labeling; In Vitro; Infarction; Injury; Inpharzam Brand of Acetylcysteine; Insertion of catheter into heart chamber; Intravenous; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; KIM-1 protein, rat; Kidney; Kidney Diseases; Kidney Failure; Kidney Insufficiency; L-Alpha-acetamido-beta-mercaptopropionic Acid; Left; Left Ventricular Function; Ligation; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mercapturic Acid; Microbeads; Microspheres; Miniature Swine; Minipigs; Modeling; Molecular; Monitor; Monitoring, Physiologic; Monitoring, Physiological; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muco Sanigen; Mucocedyl; Mucolator; Mucolyticum; Mucomyst; Mucosolvin; Mucret; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocardial tissue; Myocardium; N-Acetyl Cysteine; N-Acetyl-L-cysteine; N-Acetylcysteine; N-acetyl-3-mercaptoalanine; NAC; NAC Zambon; NMR Imaging; NMR Tomography; Neo-Fluimucil; Nephropathy; Nuclear Magnetic Resonance Imaging; Observational Study; Optipect Hustengetr??nk; Parvolex; Patients; Perfusion; Physiologic Monitoring; Physiopathology; Pigs; Produpharm Lappe Brand of Acetylcysteine; Protocol; Protocols documentation; Radiopaque Media; Renal Disease; Renal Failure; Renal Insufficiency; Renal Tissue; Renal function; Reperfusion Therapy; Respaire; Risk; Roberts Brand of Acetylcysteine; Safety; Sampling; Serum; Simulate; Staining method; Stainings; Stains; Stains, Tissue; Suidae; Swine; Swine, Miniature; TUNEL; Tachycardia, Ventricular; Telemetries; Telemetry; Testing; Thiemann Brand of Acetylcysteine; Time; Tissue Sample; Tissue Stains; Tissues; Tixair; Toxic effect; Toxicities; Tubular; Tubular formation; UPSA Brand of Acetylcysteine; Urinary System, Kidney; Urinary System, Urine; Urine; Ventricular; Ventricular Function, Left; Ventricular Tachycardia; Zambon Brand of Acetylcysteine; Zeugmatography; Zyma Brand of Acetylcysteine; anti-oxidant; cardiac infarct; cardiac muscle; clinical investigation; clinical practice; coronary attack; coronary disorder; coronary infarct; coronary infarction; design; designing; electrocardiographic monitor; heart attack; heart infarct; heart infarct sizing; heart infarction; heart infarction sizing; heart ischemia; heart muscle; hemodynamics; in vivo; infarct; kidney disorder; kidney function; kidney injury molecule 1; mini pig; model organism; myocardial infarct sizing; myocardial infarction sizing; myocardial ischemia/hypoxia; myocardium ischemia; pathophysiology; percutaneous coronary intervention; porcine; protective effect; public health relevance; rat KIM-1 protein; renal; renal KIM-1; renal disorder; reperfusion; suid; terminal nick end labeling",Cardiac and Renal Effects of N-Acetylcysteine," The detection of coronary heart disease or the treatment of heart attacks requires the use of contrast agents. Unfortunately, these contrast agents are toxic to the kidneys and some patients will develop kidney failure. We are investigating if the antioxidant N-Acetylcysteine added to a contrast agent can reduce kidney toxicity and protect the heart at the same time.",94807,MIM,Myocardial Ischemia and Metabolism Study Section,A1,1,188125,
7787242,R21,HL,1,,01/04/2010,11/30/2010,PA-06-181,1R21HL095891-01A1,,NHLBI:203125;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"SAM, FLORA ;",6384806;,1R21HL095891,01/04/2010,11/30/2011,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Active Follow-up; Affect; Amyloid; Amyloid Fibrils; Amyloid Substance; Amyloidosis; Arrhythmia; Biological Preservation; Blood; Body Tissues; Boston; CLG; Cardiac; Cardiac Arrhythmia; Cardiac Failure Congestive; Cardiac Myocytes; Cardiocyte; Cell-Extracellular Matrix; Cessation of life; City of Boston; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Congestive Heart Failure; Data; Death; Deposit; Deposition; Detection; Diagnosis; Disease Progression; Dysfunction; ECM; Echocardiogram; Echocardiography; Educational workshop; Extracellular Matrix; Fibrils, Amyloid; Fibroblast Collagenase; Forecast of outcome; Functional disorder; Future; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Grafting, Heart; Grant; HOSP; Heart; Heart Arrhythmias; Heart Decompensation; Heart Failure, Congestive; Heart Transplantation; Heart failure; Heart myocyte; Hospitalization; Hospitals; Housing; Immunoglobulins, Light-Chain; Infiltration; Interstitial Collagenase; Lead; Light; Light-Chain Immunoglobulins; MMP-1; MMP-1Fibroblast Collagenase; MMP-2; MMP-9; MMP-9 Protein; MMP1; MMP2; MMP9; MMPs; Macrophage Gelatinase; Matrix Metalloproteinase-1; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Measures; Medical center; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial depression; Myocardial dysfunction; Myocytes, Cardiac; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organ System; Outcome; PEX; Pathogenesis; Pathologic; Patients; Pattern; Pb element; Photoradiation; Physiopathology; Play; Prealbumin; Preservation, Biologic; Preservation, Biological; Prevention; Proalbumin; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; Rare Diseases; Rare Disorder; Research; Research Priority; Reticuloendothelial System, Blood; Risk; Role; Sampling; Stratification; Stress; TIMP-1; TIMP-4; TIMP-4 protein; Testing; Therapeutic Intervention; Time; Tissue Inhibitor of Metalloproteinase-1; Tissues; Transplantation, Cardiac; Transthoracic Echocardiography; Transthyretin; Type V Collagenase; United States National Institutes of Health; Universities; Work; Workshop; amyloid disease; biomarker; body system; cardiac failure; cardiac graft; cardiomyocyte; clinical investigation; cohort; follow-up; gene product; heart sonography; heart transplant; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; insight; intervention therapy; mutant; new therapeutic target; novel; outcome forecast; pathophysiology; preservation; prevent; preventing; programs; public health relevance; repository; response; social role; sound measurement; tissue inhibitor of metalloproteinase 4",Novel Insights into the Pathogenesis of  Light Chain Cardiac Amyloidosis," Systemic amyloidosis is a rare disease that affects many organ systems, the most devastating and lethal of which is cardiac involvement. Cardiac involvement and its resultant dysfunction is the least understood aspect of amyloid pathophysiology, therefore improved detection and treatment is needed. In response to statements from the U.S. House of Representatives Appropriations Committee on the need for additional research in amyloidosis, the Office of Rare Diseases (NIH) sponsored a workshop and is promoting amyloidosis-related grants and as a result amyloidosis is considered to be a high priority for research in the field.",95891,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,A1,1,203125,
7789816,R21,HL,1,,01/12/2010,11/30/2010,PA-06-181,1R21HL095957-01A1,,NHLBI:232449;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MEMPHIS,UNITED STATES,PHYSIOLOGY,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"YUE, JUNMING ;",9196967;,1R21HL095957,01/12/2010,11/30/2011,"1-Phosphatidylinositol 3-Kinase; 3' Untranslated Regions; 3'UTR; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Age; Akt protein; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; B-Cell CLL/Lymphoma 2 Gene; BCL2; BCL2 gene; BZS; Biological; Biological Function; Biological Process; Blood Vessels; Body Size; Cancers; Cardiac; Cardiovascular Diseases; Carotid Arteries; Carotid Arteriopathies, Traumatic; Carotid Artery Injuries; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Common Rat Strains; Defect; Development; Diagnosis; Disease; Disorder; EC 2.7.2-; Exhibits; Extracellular Signal-Regulated Kinases; Extremities; Functional RNA; Gene Expression; Generalized Growth; Genes; Genes, bcl-2; Genetic Condition; Genetic Diseases; Grant; Growth; HTRPY; Heart Hypertrophy; Hereditary Disease; Human; Human, General; Hyperplasia; Hyperplastic; Hypertension, Pulmonary; Hypertrophy; Injury; Intracellular Communication and Signaling; Knockout Mice; Leiomyocyte; Lentiviral Vector; Lentivirus Vector; Limb structure; Limbs; MAP kinase; MAPK; MHAM; MMAC1; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Messenger RNA; Methods; Mice; Mice, Knock-out; Mice, Knockout; Micro RNA; MicroRNAs; Microscopic; Mitogen-Activated Protein Kinases; Modeling; Molecular; Molecular Disease; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Myocytes, Smooth Muscle; Non-Coding; Non-Coding RNA; Non-Trunk; Null Mouse; Oncogenic; PI-3 Kinase; PI-3K; PI3-Kinase; PKB protein; PTEN; PTEN gene; PTEN1; Palsy; Paralysed; Pathway interactions; Phenotype; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Physiologic; Physiological; Play; Plegia; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Kinase B; Proteins; Proto-Oncogene Proteins c-akt; PtdIns 3-Kinase; Pulmonary Hypertension; RAC-PK protein; RNA, Messenger; Rat; Rattus; Regulation; Reporting; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Testing; Tissue Growth; Transgenic Organisms; Translations; Trauma, Carotid Artery; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Vascular Diseases; Vascular Disorder; Viral Diseases; Virus Diseases; base; biological signal transduction; blood vessel disorder; c-akt protein; cardiac hypertrophy; cardiovascular disease therapy; cardiovascular disorder; cardiovascular disorder therapy; ced9 homolog; disease/disorder; gene product; genetic disorder; hereditary disorder; injured; insight; mRNA; malignancy; miRNA; model organism; molecular phenotype; mouse model; neointima formation; neointimal thickening; neoplasm/cancer; ontogeny; overexpression; paralysis; paralytic; pathway; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; related to A and C-protein; social role; transgene expression; transgenic; vascular; viral infection; virus infection",Transgenic rat overexpressing miR-21 in vascular smooth muscle cells:functional i, Project Narrative This proposal is to characterize transgenic rats expressing miR-21 using lentiviral vector to address the biological functions of miRNAs by targeting miR-21 gene into vascular smooth muscle cells. The phenotype and molecular mechanisms underlying the phenotypes will also be examined using this transgenic rat models by investigating how miR-21 is involved in the posttranscriptional regulation.,95957,ZRG1,Special Emphasis Panel,A1,1,232449,
7789392,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL096047-01A1,,NHLBI:231750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"CHEN, SONGCANG ;",8033640;,1R21HL096047,01/15/2010,12/31/2011,"1,25-Dihydroxycholecalciferol Receptors; 1,25-Dihydroxyvitamin D3 Receptors; 21+ years old; 25-Hydroxycholecalciferol; 25-Hydroxyvitamin D 3; 25-Hydroxyvitamin D3; 25-hydroxy-D3; 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5Z,7E)-; Adult; Agonist; Angioplasty; Animal Model; Animal Models and Related Studies; Animals; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Band Shift Mobility Assay; Bandshift Mobility Assay; Bioassay; Biologic Assays; Biological Assay; Blood Pressure, High; Blood Vessels; Body Tissues; Breast; Bypass; CHIP assay; Calcidiol; Calcifediol; Cancers; Cardiac Failure Congestive; Carotid Arteries; Carotid Arteriopathies, Traumatic; Carotid Artery Injuries; Cell Cycle; Cell Division Cycle; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Cholecalciferol Receptors; Chromosomes; Chronic; Common Rat Strains; Common carotid artery; Congestive Heart Failure; Constriction, Pathologic; Constriction, Pathological; Data; Development; Disease; Disorder; Distal; EC 2.7; Electrophoretic Mobility Shift Assay; Endothelin; Endothelium; Endothelium-Derived Vasoconstrictor Factors; Exons; Gatekeeping; Gene Expression; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Genital System, Male, Prostate; Growth; Health; Heart Decompensation; Heart Failure, Congestive; Heart Hypertrophy; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, General; Hypercalcemia; Hyperplasia; Hyperplastic; Hypertension; In Vitro; Injury; Kinases; Knockout Mice; Leiomyocyte; Ligands; Link; MTGN; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mitogenesis; Mitogens; Mobility Shift Assay; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Murine; Mus; Myocytes, Smooth Muscle; Null Mouse; Pathogenesis; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Phosphotransferases; Play; Positive Control of Cell Proliferation; Prevention; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate Gland; Prostatic Gland; RNA Expression; Rat; Rattus; Receptor Gene; Receptors, 1,25-Dihydroxyvitamin D 3; Receptors, Calcitriol; Research; Role; Scanning; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Stenosis; Stents; Stimulation of Cell Proliferation; Testing; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transphosphorylases; Transplantation; Trauma, Carotid Artery; VDR; VIT D; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Veins; Vitamin D; Vitamin D 3 Receptors; Vitamin D Deficiency; Vitamin D Receptors; Vitamin D3 Receptor; adult human (21+); analog; atheromatosis; atherosclerotic vascular disease; blood vessel disorder; cancer cell; cardiac hypertrophy; cell growth; cell type; chromatin immunoprecipitation; conformation; conformational state; disease/disorder; gatekeeper; gel shift assay; graft failure; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; injured; insight; intraluminal angioplasty; malignancy; model organism; mouse model; neoplasm/cancer; novel; ontogeny; peripheral blood vessel disorder; public health relevance; receptor binding; response; social role; transplant; vascular; vascular smooth muscle cell proliferation",A Role for Non-Hypercalcemic VDR Agonists in the Control of VSMC Proliferation," Public Health Relevance Statement Aberrant vascular smooth muscle cell (VSMC) growth plays a pivotal role in the pathogenesis of chronic vascular disease, e.g. atherosclerosis and hypertension, and in subacute vascular injury, as seen in transplant vasculopathy, in-stent stenosis and vein bypass graft failure. Research outlined in this proposal will seek to generate evidence that VD3 analogues suppress abnormal VSMC growth in an animal model and help to substantiate the hypothesis that vitamin D sufficiency is important for maintenance of vascular health.",96047,ZRG1,Special Emphasis Panel,A1,1,231750,
7788940,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL097131-01A1,,NHLBI:222000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,EMERGENCY MEDICINE,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"MILLER, CHADWICK DAVID;",8717943;,1R21HL097131,01/15/2010,12/31/2011,"Address; Admission; Admission activity; Adopted; Adverse Experience; Adverse event; Aging; Algorithms; American; American Heart Association; Atomic Medicine; Baptist Church; Baptists; Cardiac; Cardiology; Cardiovascular Disease (Specialty); Caring; Cessation of life; Chest Pain; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coronary; Coronary Disease; Coronary heart disease; Death; Diagnosis; Diagnostic; Diagnostic tests; Discipline of Nuclear Medicine; Electromagnetic Radiation, Ionizing; Emergencies; Emergency Situation; Evaluation; Event; Exercise; Exercise, Physical; Exposure to; Goals; Guidelines; HOSP; Healthcare Systems; Hospitalization; Hospitals; Image; Infarction; Inpatients; Investigation; Ionizing radiation; Ischemia; Lead; Length of Stay; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical center; Methods; Modality; Monitor; Mortality; Mortality Vital Statistics; Myocardial perfusion; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Nuclear Medicine; Number of Days in Hospital; Outcome; PROV; Participant; Patients; Patterns of Care; Pb element; Population; Probability; Procedures; Process; Protocol; Protocols documentation; Provider; Radiation; Radiation-Ionizing Total; Radiology / Radiation Biology / Nuclear Medicine; Radiology-Nuclear Medicine; Randomized; Randomized Clinical Trials; Recruitment Activity; Recurrence; Recurrent; Research; Research Resources; Resources; Rest; Risk; Safety; Senescence; Stratification; Stress; Stress Tests; Structure; Symptoms; Systems, Health Care; Technology; Testing; Time; Triage; Trials, Randomized Clinical; Universities; Zeugmatography; acute coronary syndrome; base; calcification; clinical investigation; college; coronary disorder; cost; design; designing; forest; heavy metal Pb; heavy metal lead; high risk; hospital days; hospital length of stay; hospital stay; imaging; improved; indexing; infarct; patient population; primary outcome; public health relevance; randomisation; randomization; randomly assigned; ray (radiation); recruit; secondary outcome; senescent",Randomized Investigation of Chest Pain Diagnostic Strategies," Project Narrative The US health care system cannot afford to continue lengthy inpatient evaluations for patients with chest pain. This investigation will determine if a cardiac MRI strategy in a clinical decision unit is more efficient at delivering care to patients with chest pain than an inpatient care strategy. Because of the large number of patients evaluated for chest pain in the US, improvements in the care processes for these patients will have a large positive societal impact.",97131,CASE,Cardiovascular and Sleep Epidemiology Study Section,A1,1,222000,
7772428,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL098711-01,,NHLBI:248250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RUDDLE, NANCY H;",1959466;,1R21HL098711,01/15/2010,12/31/2011,"APC; ATGN; Abbreviations; Antigen-Presenting Cells; Antigens; Autoimmune Status; Autoimmunity; Automobile Driving; Blood Circulation; Bloodstream; Body Tissues; CD44 Adhesion Receptor; CD44 Antigens; CD44 molecule; Cachectin; Cachectin-Tumor Necrosis Factor; Cancers; Cells; Characteristics; Chronic; Chylothorax; Circulation; Common Rat Strains; Communicable Diseases; DIF; Development; Drivings, Automobile; Dysfunction; EC 2.8.2; Endothelial Cells; Exhibits; FP593; Functional disorder; GFP; Galactosidase; Gastrointestinal Tract, Pancreas; Generalized Growth; Genes; Genes, LacZ; Genes, Reporter; Goals; Greater sac of peritoneum; Green Fluorescent Proteins; Growth; HUTCH-1; Hermes Antigen; High Endothelial Venule; Homeo Boxes; Homeobox; Humulin R; Hyaluronan-Binding Protein; Hyaluronic Acid Binding Protein; INFLM; Image; Imaging Device; Imaging Tool; Immune response; Immune system; Immunization; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intercellular Fluid; Interstitial Fluids; LTA; LacZ; LacZ Genes; Life; Lipid Trafficking; Liquid substance; Lymph; Lymph node proper; Lymphangiogeneses; Lymphangiogenesis; Lymphatic; Lymphatic Tissue; Lymphatic vessel; Lymphedema; Lymphoid; Lymphoid Tissue; Lymphotoxin; Lymphotoxin A; Lymphotoxin-alpha; MECA-79 antigen; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Microscopy; Monocytes / Macrophages / APC; Murine; Mus; NMR Imaging; NMR Tomography; Nasal; Nose; Nose, Nasal Passages; Novolin R; Nuclear Magnetic Resonance Imaging; Organ; PLPF; PNAd; Pancreas; Pancreatic; Peripheral; Peritoneal Cavity; Physiopathology; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Rat; Rattus; Receptors, Hyaluronan; Regulation; Reporter; Reporter Genes; Respiratory System, Nose, Nasal Passages; Reticuloendothelial System, Lymph; Reticuloendothelial System, Lymph Node; Sensitization, Immunologic; Sensitization, Immunological; Site; Staining method; Stainings; Stains; TNF; TNF (unspecified); TNF A; TNF Receptor Ligands; TNF Superfamily, Member 1; TNF gene; TNF-alpha; TNF-b; TNF-beta; TNFSF1; TNFSF2; Techniques; Technology; Temperature; Therapeutic; Time; Tissue Growth; Tissues; Transgenes; Transgenic Mice; Transplantation; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-Beta; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Vascular System; Zeugmatography; accessory cell; body system, allergic/immunologic; drFP583; driving; ds red protein; dsFP593; fluid; gene product; gp85; host response; imaging; immunogen; immunoresponse; in vivo; injured; insight; interstitial; lipid transport; liquid; lymph gland; lymph nodes; lymphatic fluid; malignancy; neoplasm/cancer; ontogeny; organ system, allergic/immunologic; pathophysiology; periodate-lysine-paraformaldehyde; peripheral lymph node addressin; podoplanin; public health relevance; red fluorescent protein; residence; self recognition (immune); sulfotransferase; theories; transplant; tumor necrosis factor (unspecified)",Lymphatic Vessel Imaging," A thorough understanding of lymphangiogenesis and lymphatic vessel function will provide therapeutic insight into lymphatic function and dysfunction in conditions such as lymphedema. Imaging tools for lymphatic vessels will provide insight into how this vascular system is maintained and regulated during an immune response and provide insight into lymphangiogenesis in inflammation, transplantation, autoimmunity, infectious diseases, and cancer. )",98711,CDD,Cardiovascular Differentiation and Development Study Section,,1,248250,
7773677,R21,HL,1,,01/12/2010,11/30/2010,PA-06-181,1R21HL098777-01,,NHLBI:229500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,STORRS-MANSFIELD,UNITED STATES,PHARMACOLOGY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"VINOGRADOVA, OLGA ;",1879061;,1R21HL098777,01/12/2010,11/30/2011,"Affinity; Apoptosis; Apoptosis Pathway; Avidity; Binding; Binding (Molecular Function); Biology; Blood; Blood Cells; Blood Vessels; Body Tissues; Cell Adhesion; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cell-Extracellular Matrix; Cells; Cellular Adhesion; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Clinic; Collaborations; Communication; Complex; Cytoplasmic Domain; Cytoplasmic Tail; Cytoskeletal System; Cytoskeleton; Data; Development; Diabetic Retinopathy; Disease; Disorder; ECM; Endothelial Cells; Endothelium; Event; External Domain; Extracellular Domain; Extracellular Matrix; Extracellular Matrix, Integrins; Family; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Foundations; GFAC; Generations; Genetic Alteration; Genetic Change; Genetic defect; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; In Vitro; Injury; Integrin Binding; Integrins; Intracellular Communication and Signaling; Investigation; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Lead; Ligand Binding; Link; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Motility; Motility, Cellular; Mutate; Mutation; Neoplasm Metastasis; Pathogenesis; Pb element; Peptide Signal Sequences; Peptides; Peripheral Blood Cell; Physiologic; Physiological; Play; Process; Receptor Cross-Talk; Receptor Protein; Regulation; Reticuloendothelial System, Blood; Role; Secondary Neoplasm; Secondary Tumor; Series; Shapes; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic Agents; Tissues; Tube; Tumor Cell Migration; Tyrosine Phosphorylation; Uncertainty; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptors; VEGFR; VEGFR-2; VEGFR2; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vegf; Vitronectin Receptors; adhesion receptor; angiogenesis; base; biological signal transduction; cancer metastasis; cell motility; conformation; conformational state; density; design; designing; disease/disorder; doubt; extracellular; genome mutation; heavy metal Pb; heavy metal lead; in vivo; intracellular skeleton; migration; mutant; new therapeutics; next generation therapeutics; novel; novel therapeutics; protein complex; protein protein interaction; protein signal sequence; public health relevance; receptor; response; social role; tumor; tumor growth; vascular",Investigation of the VEGFR/Integrin cytoplasmic domains interaction.," This proposal presents the evidence that there is a complex between VEGFR2 and integrin 3 cytoplasmic tails. We will investigate the exact mechanisms and the role of this interaction: the VEGF-integrin partnership may serve as an important model for fundamental studies of the communication between growth factors and cell adhesion systems. Our data may ultimately lead to a new paradigm for understanding how VEGF and integrin cross talk and regulate the complex cell adhesion events and angiogenic response. Moreover, our structural approach should contribute to the development of new therapeutic agents designed to inhibit integrin (and other receptors) cytoplasmic domain protein-protein interactions.",98777,ZRG1,Special Emphasis Panel,,1,229500,
7772910,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL098782-01,,NHLBI:241441;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,STANFORD,UNITED STATES,PEDIATRICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"RABINOVITCH, MARLENE ;",2417466;,1R21HL098782,01/15/2010,12/31/2011,"5-HT Receptors; 5-Hydroxytryptamine Receptors; Accounting; Adventitial Cell; Affinity; Antibodies; Antigens, Viral; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Biological; Blood Serum; Blood Vessels; Cell Death, Programmed; Cells; Clinical; Cloning, Human; Complementary DNA; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; DNA, Complementary; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disorder; Elastases; Elastin; Endothelial Cells; Environmental Factor; Environmental Risk Factor; Enzymes; Exhibits; Future; GeneHomolog; Genes; Genetic; Homolog; Homologous Gene; Homologue; Human; Human Cloning; Human, General; Hypertension, Pulmonary; Immune Precipitation; Immunoprecipitation; Infection; Inflammatory; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi?s Sarcoma; Knockout Mice; L-Serine; Leiomyocyte; Length; Lesion; Link; Lung; Lung Parenchyma; Lung Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Micro RNA; MicroRNAs; Microcirculation; Modeling; Molecular Interaction; Multiple Hemorrhagic Sarcoma; Murine; Mus; Myocytes, Smooth Muscle; Null Mouse; Organ Culture; Organ Culture Techniques; PI3 protein, human; Pathogenesis; Pathology; Patients; Peptides; Pericapillary Cell; Pericytes; Perivascular Cell; Photometry/Spectrum Analysis, Mass; Play; Predisposition; Proteins; Pulmonary Artery; Pulmonary Hypertension; Pulmonary artery structure; Recombinants; Recurrence; Recurrent; Respiratory System, Lung; Role; Rouget Cells; SKALP; Serine; Serum; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Structure of parenchyma of lung; Susceptibility; Transgenic Mice; Transplantation; Variant; Variation; Vascular Diseases; Vascular Disorder; Viral Antigens; Viral Burden; Viral Diseases; Viral Load; Viral Load result; Virus; Virus Activation; Virus Diseases; Virus Induction; Viruses, General; WAP four-disulfide core domain protein 14, human; WAP3 protein, human; aminoacid sequence of peptide; aminoacid sequence of protein; blood vessel disorder; cDNA; clinical data repository; clinical data warehouse; data repository; disease/disorder; elafin; environmental risk; gene product; human disease; inhibitor; inhibitor/antagonist; insight; miRNA; migration; mutant; new approaches; novel; novel approaches; novel strategies; novel strategy; overexpression; peptide sequence; prevent; preventing; protease inhibitor 3, skin-derived (SKALP), human; protein aminoacid sequence; protein structure; public health relevance; pulmonary; pulmonary arterial hypertension; relational database; response; serotonin receptor; skin-derived antileukoproteinase; social role; transcription factor; transplant; vascular; viral infection; virus antigen; virus infection",Identifying the Serine Elastase Elevated in Pulmonary Vascular Disease," IDENTIFYING THE SERINE ELASTASE ELEVATED IN PULMONARY VASCULAR DISEASE Project Narrative: Our group has shown that an enzyme called endogenous vascular elastase (EVE) plays a pivotal role in the pathogenesis of pulmonary arterial hypertension (PAH) and that inhibition of EVE may be a strategy to reverse the disease. We therefore plan to establish the structure of both the murine form of EVE and of the human enzyme, so that in the future highly targeted therapies can be developed to inhibit its activity. We also propose to determine whether EVE may be regulated by a microRNA and whether the level of this microRNA determines host susceptibility to virus-induced pulmonary vascular disease.",98782,ZRG1,Special Emphasis Panel,,1,241441,
7773180,R21,HL,1,,02/01/2010,01/31/2011,PA-06-181,1R21HL098786-01,,NHLBI:189194;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW ORLEANS,UNITED STATES,PATHOLOGY,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"VANDER HEIDE, RICHARD ;",2097400;,1R21HL098786,02/01/2010,01/31/2012,"Accident and Emergency department; Acidity; Adenosine; Adverse effects; Animal Model; Animal Models and Related Studies; Antioxidants; Area; Arts; Biochemical; Biological Models; Body Tissues; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cell Death; Cellular Matrix; Cessation of life; Clinical Trials; Clinical Trials, Unspecified; Cytoskeletal System; Cytoskeleton; Death; Development; Dose; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; Emergency Department; Emergency room; Event; Formulation; Formulations, Drug; Free Radical Scavengers; Free Radicals; H element; Healthcare Systems; Heart; Heart myocyte; Human; Human, General; Hydrogen; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; In Vitro; Infarction; Injury; Investigators; Ischemia-Reperfusion Injury; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Kinetic; Kinetics; Laboratories; Life; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Mitochondria; Model System; Modeling; Models, Biologic; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes; Myocytes, Cardiac; Na element; Nanoscale Science; Nanotechnology; Necrosis; Necrotic; O element; O2 element; Outcome; Oxygen; Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phosphates; Play; Polymers; Preparation; Proteins; Public Health Service; Public Health Service (U.S.); Pump; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Research Personnel; Researchers; Role; Side; Sodium; Systems, Health Care; Techniques; Testing; Therapeutic; Therapeutic Agents; Time; Tissues; Toxic effect; Toxicities; Treatment Side Effects; USPHS; United States; United States Public Health Service; Ventricular; anti-oxidant; base; cardiac infarct; cardiac muscle; cardiomyocyte; catalase; clinical investigation; coronary attack; coronary infarct; coronary infarction; cost; design; designing; drug/agent; gene product; heart attack; heart function; heart infarct; heart infarction; heart ischemia; heart muscle; improved; in vivo Model; infarct; inhibitor; inhibitor/antagonist; inorganic phosphate; intracellular skeleton; mitochondrial; model organism; myocardial ischemia/hypoxia; myocardium ischemia; nano particle; nano scale Science; nano tech; nano technology; nanoparticle; nanotech; necrocytosis; new therapeutics; next generation therapeutics; novel therapeutics; oxidative damage; particle; prevent; preventing; public health relevance; reperfusion; side effect; social role; therapy adverse effect; trafficking; treatment adverse effect",New methods to deliver therapeutic drugs in myocardial ischemia/reperfusion injur," Public Health Service Relevance Statement Significance: If achievable, this drug delivery vehicle could be given to a patient with a developing heart attack (i.e. a developing myocardial infarct) in the field or in the emergency department and directly reduce the cell death resulting from the event. The best predictor of morbidity and mortality subsequent to myocardial infarction is the amount of heart tissue that dies. Therefore, if the drug reduces the amount of cell death, it will directly reduce morbidity, mortality, and the cost to the patient and the overall health care system. Furthermore, our delivery vehicle is not restricted to the use of a single drug. In these initial studies we will use the readily available, well-characterized antioxidant catalase. However, the delivery vehicle would be adaptable to many other free radical scavengers as well other drugs that could be designed to directly reduce or prevent myocyte cell death. The ultimate outcome of such a drug delivery vehicle could have a large impact on the health care system in the United States.",98786,MIM,Myocardial Ischemia and Metabolism Study Section,,1,189194,
7773652,R21,HL,1,,01/01/2010,11/30/2010,PA-06-181,1R21HL098802-01,,NHLBI:195000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEWARK,UNITED STATES,BIOCHEMISTRY,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"TIAN, BIN ;",7860837;,1R21HL098802,01/01/2010,11/30/2011,"Alternate Splicing; Alternative Splicing; Assay; Bioassay; Biologic Assays; Biological Assay; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cardiomegaly; Cause of Death; Computing Methodologies; Data; Development; Disease; Disorder; Elements; Enlarged Heart; Event; Exons; Extracellular Structure; Fetus; Foundations; Future; Gene Action Regulation; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Goals; Growth; HTRPY; Heart; Heart Diseases; Heart Enlargement; Heart Hypertrophy; Heart failure; Heart myocyte; Human; Human, General; Hypertrophy; Knowledge; Lead; Left Ventricles; Left ventricular structure; Light; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mechanics; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Micro RNA; MicroRNAs; Molecular; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocytes, Cardiac; Pattern; Pb element; Photoradiation; Physiology; Play; Polyadenylation; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; RNA Expression; RNA Polyadenylation; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger; RNA-Binding Proteins; Regulation; Regulatory Element; RegulatoryElement; Reporter; Reporting; Reverse Transcription; Role; Signal Pathway; Site; Solid; Splicing; Staging; Techniques; Therapeutic; Tissue Growth; Transcription; Transcription, Genetic; United States; cardiac failure; cardiac hypertrophy; cardiogenesis; cardiomyocyte; computational methodology; computational methods; computer methods; constriction; design; designing; disease/disorder; effective therapy; fetal; gene expression signature; genome-wide; heart development; heart disorder; heavy metal Pb; heavy metal lead; mRNA; miRNA; ontogeny; pressure; programs; public health relevance; response; social role; transcriptome",Alternative mRNA processing in cardiac hypertrophy," Project Narrative Cardiac hypertrophy is enlargement of the heart in response to increased mechanical load, which often leads to heart failure. Heart failure is one of the leading causes of death in the United States. Understanding the molecular mechanism underlying cardiac hypertrophy will help us design effective therapies to mitigate or cure the disease.",98802,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,1,195000,
7773717,R21,HL,1,,01/15/2010,12/31/2010,PA-06-181,1R21HL098850-01,,NHLBI:185000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,GENETICS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"KOLLER, BEVERLY H;",1881083;,1R21HL098850,01/15/2010,12/31/2011,"ANG-(1-8)Octapeptide; Accounting; Address; Alleles; Allelomorphs; Alu Elements; Alu Family; Alu Repetitive Sequences; AngII; Angiotensin Converting Enzyme; Angiotensin I; Angiotensin I-Converting Enzyme; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensinogen; Angiotensinogen (protein renin substrate); Apoplexy; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Autoregulation; Blood Pressure; Blood Pressure, High; Body Tissues; Bradykinin; CD143 Antigens; Candidate Disease Gene; Candidate Gene; Carboxycathepsin; Cardiac Diseases; Cardiac Disorders; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Causality; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic Disease; Chronic Illness; Clinical; Complex; Computer Systems Development; Conflict; Conflict (Psychology); Consensus; Development; Development, Computer Systems; Diabetic Kidney Disease; Diabetic Nephropathy; Dipeptidyl Peptidase A; Disease; Disorder; ES Cell Line; ES cell; ESRD; Embryonic Stem Cell Line; End stage renal failure; End-Stage Kidney Disease; Enzyme Gene; Enzymes; Etiology; Gene variant; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetics, Human; Haplotypes; Healthcare; Heart Diseases; Hereditary Disease; History; Homeostasis; Human; Human Genetics; Human, General; Hypertensinogen; Hypertension; Individual; Intervening Sequences; Introns; Kidney; Kidney Diseases; Kininase A; Kininase II; Link; Linkage Disequilibrium; Linkage Disequilibriums; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mice; Modification; Molecular Disease; Morbidity; Morbidity - disease rate; Murine; Mus; Na element; Nephropathy; Organ; Organ System, Cardiovascular; Ortholog; Orthologous Gene; Pathogenesis; Peptides; Peptidyl-Dipeptidase A; Phenotype; Physiological Homeostasis; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Pressure; Pressure- physical agent; Prevalence; Proangiotensin; Recording of previous events; Regulation; Renal Disease; Renal Disease, End-Stage; Renal function; Renin-Angiotensin System; Renin-Substrate; Reporting; Risk; Risk Factors; Role; Societies; Sodium; Stroke; Susceptibility; System; System, LOINC Axis 4; Systems Development; Testing; Tissues; Urinary System, Kidney; Variant; Variation; Variation (Genetics); Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; allelic variant; brain attack; cardiovascular risk; cardiovascular risk factor; cell type; cerebral vascular accident; chronic disease/disorder; chronic disorder; circulatory system; disease causation; disease etiology; disease risk; disease/disorder; disease/disorder etiology; disorder etiology; disorder risk; embryonic stem cell; enzyme activity; genetic disorder; heart disorder; hereditary disorder; homologous recombination; human DNA; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; kallidin 9; kallidin I; kidney disorder; kidney function; mouse model; novel; polymorphism; pressure; public health relevance; renal; renal disorder; social; social role; stem cell of embryonic origin; stroke; vector",Functional consequences of RAS polymorphisms," NARRATIVE Hypertension is a common, chronic disease, and represents an important risk factor for stroke, heart disease and end stage renal disease. With a prevalence of approximately 27% world wide this disease places an enormous economical, health care and social burden on society. There is general consensus that genetic factors contribute to individual susceptibilities to hypertension, and many candidate genes and polymorphisms have been identified through human genetic studies. However, determination of which of these polymorphism(s) is functional and delineation of the mechanism by which the polymorphisms confer risk for disease has been difficult. In this application, using polymorphisms in the ACE gene as an example, we propose a new method for approaching this problem.",98850,GHD,Genetics of Health and Disease Study Section,,1,185000,
7788906,R21,NS,1,,01/15/2010,12/31/2010,PA-06-181,1R21NS060675-01A2,,NINDS:231000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NEUROSURGERY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"MATHERN, GARY W;",1866758;,1R21NS060675,01/15/2010,12/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Animals; Anisotropy; Astroprotein; Au element; Body Tissues; Brain; Causality; Cell Communication and Signaling; Cell Signaling; Cerebral cortex; Cessation of life; Data; Death; Diffuse; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Drug Controls; EEG; Electric Conductivity; Electrical Conductivity; Electrodes; Electroencephalography; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Etiology; Evaluation; GFA-Protein; GFAP; Glial Fibrillary Acid Protein; Glial Fibrillary Acidic Protein; Glial Intermediate Filament Protein; Gliosis; Goals; Gold; Grant; Hydrogen Oxide; Individual; Intracellular Communication and Signaling; Lead; Lesion; MR Imaging; MR Tomography; MRI; MRI Scans; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mental Retardation; Methods; Methods and Techniques; Methods, Other; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myelin; Myelin Basic Proteins; NMR Imaging; NMR Tomography; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Pathology; Patients; Pb element; Proteins; Proteolipids; Public Health; Refractory; Research Technics; Risk; Scalp; Scalp structure; Scanning; Scans, MRI; Science of neurosurgery; Seizure Disorder; Seizures; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Structure; Surface; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Techniques, Research; Tissues; Water; Work; Zeugmatography; biological signal transduction; brain tissue; diffusion tensor imaging; disease causation; disease etiology; disease/disorder etiology; disorder etiology; electrical conductance; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gene product; gray matter; heavy metal Pb; heavy metal lead; improved; in vivo; model organism; nervous system disorder; neurological disease; neurosurgery; public health medicine (field); public health relevance; research study; resistance to therapy; resistant to therapy; substantia alba; substantia grisea; surgery; therapy resistant; tool; water diffusion; white matter",Mechanisms Altering Electrical Conductivity & DTI in Epilepsy Surgery Patients," Project Narrative  One-third of epilepsy patients have seizures that are not controlled by drugs, and are at risk for seizure- induced death and mental retardation. Surgery is an option to treat uncontrolled seizures, but less than half are candidates because of limitations of EEG and MRI techniques. This grant will improve these tools by studying if electrical signals move through the brain differently in epilepsy patients, whether electrical signal changes can be estimated using new MRI techniques, and if the electrical and MRI changes are from disorganization of the cerebral cortex.",60675,DBD,Developmental Brain Disorders Study Section,A2,1,231000,
7788439,R21,NS,1,,02/01/2010,01/31/2011,PAR-08-232,1R21NS062992-01A1,,NINDS:230250;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,PEDIATRICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"SWANN, JOHN WILLIAM;",7358177;,1R21NS062992,02/01/2010,01/31/2012,"0-11 years old; ACTH; ACTH (1-39); Adrenocorticotropic Hormone; Adrenocorticotropin; Adverse effects; Affect; Age; Animal Model; Animal Models and Related Studies; Animal Testing; Animals; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Biological; Child; Child Youth; Children (0-21); Clinical; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Corticotropin; Corticotropin (1-39); Critiques; Development; Disease; Disorder; Disturbance in cognition; Dose; Drug Therapy; Drug usage; Drugs; Effectiveness; Epilepsy; Epileptic Seizures; Epileptics; Evaluation; Event; Frequencies (time pattern); Frequency; Fugu Toxin; Future; Generations; Goals; High Frequency Oscillation; History; Human; Human, Child; Human, General; Impaired cognition; Impairment; Incidence; Individual; Infant; Infantile spasms; Ion Channels, Sodium; Laboratories; Learning; Life; Lightning Attacks; Live Birth; Mammals, Rats; Man (Taxonomy); Man, Modern; Medication; Memory; Memory Deficit; Memory impairment; Mental Retardation; Modeling; Muscle Spasm; Muscular Spasm; Neocortex; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurons; Outcome; Outcome Measure; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Protocol; Protocols documentation; Rat; Rattus; Recording of previous events; Research; Sampling; Seizure Disorder; Seizures; Sodium Channel; Spasm; Study Section; Syndrome; TTX; Tarichatoxin; Testing; Tetradotoxin; Tetrodotoxin; Time; Treatment Side Effects; United States; Update; V (voltage); Variant; Variation; West Syndrome; West syndrome (WS); Writing; X-linked infantile spasms; attenuation; base; behavior test; behavioral test; children; cognitive dysfunction; cognitive loss; cognitively impaired; cost effective; digital; disease/disorder; dosage; drug efficacy; drug use; drug/agent; early childhood; eclampsia nutans; epilepsia; epileptiform; epileptogenic; flexion spasm; greeting spasms; homotypical cortex; improved; infancy; infantile; infantile salaam; infantile spasms with mental retardation; infantile spasms-hypsarrhythmia-mental retardation syndrome; isocortex; jackknife spasm; meetings; model organism; neopallium; nervous system disorder; neurological disease; neuronal; public health relevance; puffer fish toxin; response; side effect; therapy adverse effect; tool; treatment adverse effect; voltage; youngster",Infantile Spasms:  Tools for Therapies, Infantile Spasms is one of the most severe epilepsies of early childhood for which there is no satisfactory treatment. Using a newly developed animal model of this disorder we plan to fully characterize the spasms in these animals and test the effectiveness of ACTH in suppressing these seizures. Our goal is to develop research and analytical protocols that can be used to test new generations of rational drug therapies for this devastating neurological disorder.,62992,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,A1,1,230250,
7892207,R21,NS,1,,01/19/2010,12/31/2010,PA-08-016,1R21NS064185-01A2,,NINDS:188125;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ALBUQUERQUE,UNITED STATES,NEUROSCIENCES,01,829868723,US,NM,871310001,UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR,"ROITBAK, TAMARA ;",8827423;,1R21NS064185,01/19/2010,12/31/2011,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; Acquired brain injury; Address; Adult; Apoplexy; Area; Behavior; Blood Vessels; Brain; Brain Injuries; Brain Ischemia; Caliber; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell Survival; Cell Viability; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; D-Glucose; Dextrans; Dextrose; Diameter; Embryo; Embryonic; Encephalon; Encephalons; Endothelial Cells; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Gene Deletion; Gene Transcription; Genes; Genetic Transcription; Glucose; Goals; HIF 1 alpha; HIF-1alpha; HIF1-Alpha; HIF1A; HIF1A gene; Human, Adult; Hypoxia; Hypoxia Inducible Factor; Hypoxic; In Vitro; Injection of therapeutic agent; Injections; Injury; Intracellular Communication and Signaling; Ischemia; Ischemic Brain Injury; Ischemic Encephalopathy; Knock-out; Knockout; Knockout Mice; Lead; Link; MOP1; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Middle Cerebral Artery Occlusion; Morphogenesis; Mother Cells; Murine; Mus; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Stem Cell; Neurocyte; Neurons; Nucleus; Null Mouse; O element; O2 element; Occlusion, Middle Cerebral Artery; Oxygen; Oxygen Deficiency; Pathway interactions; Pb element; Permeability; Play; Population; Process; Progenitor Cells; Property; Property, LOINC Axis 2; Publishing; RNA Expression; Reperfusion Therapy; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stem cells; Stroke; Stroke prevention; System; System, LOINC Axis 4; TAM; Tamoxifen; Testing; Therapeutic Uses; Transcription; Transcription, Genetic; Transplantation; VEGFs; Vascular Accident, Brain; Vascular Endothelial Growth Factors; Vascular remodeling; Vegf; adult human (21+); angiogenesis; biological signal transduction; brain attack; brain damage; brain lesion (from injury); brain remodeling; brain tissue; cerebral vascular accident; density; deprivation; design; designing; dextran; experiment; experimental research; experimental study; gene deletion mutation; heavy metal Pb; heavy metal lead; immunocytochemistry; improved; in vivo; ischemic brain damage; migration; mouse model; nerve stem cell; nestin; nestin protein; neural; neural progenitor cells; neuronal; neuronal progenitor; neuronal progenitor cells; neuronal replacement; pathway; prevent stroke; public health relevance; relating to nervous system; repair; repaired; reperfusion; research study; response; social role; stem; stem cell niche; stroke; stroke recovery; transcription factor; transplant; vascular; vasculogenesis",The Role of HIF-1 alpha in Vasculotrophic Influence of Neural Stem Cells, PROJECT NARRATIVE Our main hypothesis is that neural stem cells protect brain blood vessels and induce new vessel formation following stroke. The goal of our study is to identify the molecules and mechanisms responsible for the neural stem cell-induced protection. Our findings may have important implications for the therapeutic use of stem cells in the treatment and prevention of stroke.,64185,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,A2,1,188125,
7797950,R21,NS,1,,01/15/2010,12/31/2010,PAR-08-232,1R21NS065435-01A1,,NINDS:247837;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,NEUROLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"ANDREASSON, KATRIN I;",1872704;,1R21NS065435,01/15/2010,12/31/2011,"Age; Agonist; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoplexy; Assay; Bioassay; Biologic Assays; Biological Assay; Brain; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Common Rat Strains; Data; Dinoprostone; Disease; Disorder; Dose; Drugs; EP2 receptor; EP4; EP4 receptor; ESP 13.2 protein, human; ESP-H4 protein, human; Encephalon; Encephalons; Epididymal Secretory Protein E4; Epididymis-Specific Whey-Acidic Type Four-Disulfide Core Protein; Female; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Genetic; Goals; HE4 protein, human; Hour; Human; Human, General; INFLM; In Vitro; Infarction; Inflammation; Ischemia; Major Epididymis-Specific Protein E4; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medication; Middle Cerebral Artery Occlusion; Misoprostol; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neurons; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Occlusion, Middle Cerebral Artery; Outcome Measure; PGE2; PGE2 alpha; PGE2alpha; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Prevention Measures; Prophylactic treatment; Prophylaxis; Prost-13-en-1-oic acid, 11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11alpha,13E)-; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin Receptor; Putative Protease Inhibitor WAP5; Rat; Rats, Sprague-Dawley; Rattus; Reaction Time; Receptor Protein; Recovery of Function; Reperfusion Therapy; Response RT; Response Time; Rodent; Rodent Model; Rodentia; Rodentias; Screening procedure; Sprague-Dawley Rats; Stroke; Testing; Therapeutic; Time; ULCN; Ulcer; Ulceration; Validation; Vascular Accident, Brain; WAP Domain Containing Protein HE4-V4; WAP Four-Disulfide Core Domain Protein 2; WAP four-disulfide core domain 2 protein, human; WFDC2; WFDC2 protein, human; aged; behavior test; behavioral test; brain attack; brain tissue; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; clinical investigation; cohort; disease/disorder; drug/agent; efficacy testing; epididymal secretory protein E4, human; epididymis-specific protein E4, human; epididymis-specific protein HE4, human; functional recovery; human WFDC2 protein; improved; in vivo; infarct; male; model organism; mouse model; neuronal; neurovascular unit; pre-clinical; preclinical; preclinical study; prostaglandin EP2 receptor; prostanoid receptor EP4; protective effect; psychomotor reaction time; public health relevance; receptor; reperfusion; response; screening; screenings; stroke; therapeutic target",Protective PGE2 receptors as therapeutic targets in cerebral ischemia.," Project narrative R21 We have identified a class of protective prostaglandin receptors that protect brain tissue in a rodent model of stroke and that are activated by an agonist called misoprostol, a medication that is already prescribed and in use in patients for ulcer prophylaxis. In this proposal, we will confirm the protective effects of misoprostol in a model of cerebral ischemia in young and aged rodents. Successful validation of this compound in aged rodent stroke will allow for future expanded pre-clinical studies for human stroke.",65435,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,A1,1,247837,
7895361,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS066490-01A1,,NINDS:253500;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"TURNBULL, DANIEL H;",1870007;,1R21NS066490,02/01/2010,01/31/2012,"21+ years old; Acquired brain injury; Adult; Age; Ammon Horn; Animals; Apoplexy; Behavior; Brain; Brain Diseases; Brain Disorders; Brain Injuries; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; Cells; Cellular Migration; Cellular Proliferation; Cellular injury; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Connector Neuron; Cornu Ammonis; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Dentate Fascia; Dentate Gyrus; Development; Disease; Disorder; Drug Design; Embryo; Embryonic; Encephalon; Encephalon Diseases; Encephalons; Fascia Dentata; Fluorescence Microscopy; Fore-Brain; Forebrain; Future; GFAC; Genetic; Genetically Engineered Mouse; Glia; Glial Cells; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Histology; Home; Home environment; Human; Human, Adult; Human, General; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ; Individual; Infusion; Infusion procedures; Injury; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Kolliker's reticulum; Label; Lateral Ventricle of Brain; Lateral Ventricles; Lateral ventricle structure; Lesion; Life; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetism; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Mice; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitotic; Modeling; Monitor; Mother Cells; Motility; Motility, Cellular; Movement; Murine; Mus; NMR Imaging; NMR Tomography; NRVS-SYS; Neonatal; Nerve Cells; Nerve Unit; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurologic Organ System; Neurological; Neurological Disorders; Neuronal Growth; Neuronal Injury; Neurons; Non-neuronal cell; Nuclear Magnetic Resonance Imaging; Olfactory Bulb; Patients; Progenitor Cells; Prosencephalon; Recovery of Function; Reporting; Research Resources; Resources; Rodent; Rodentia; Rodentias; Site; Staging; Stem cells; Stream; Stroke; Structure of dentate gyrus; Structure of olfactory bulb; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Effect; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Zeugmatography; adult human (21+); body movement; brain attack; brain damage; brain lesion (from injury); cell behavior; cell damage; cell injury; cell motility; cell type; cerebral vascular accident; degenerative condition; degenerative disease; dentate gyrus; disease/disorder; effective therapy; experience; experiment; experimental research; experimental study; functional recovery; hippocampal; human disease; imaging; in vivo; injury response; lateral ventricle; magnetic; migration; mouse model; nerve cement; nerve stem cell; nervous system disorder; neural progenitor cells; neuroblast; neurodegenerative illness; neurogenesis; neuroimaging; neurological disease; neuron injury; neuron toxicity; neuronal; neuronal progenitor; neuronal progenitor cells; neuronal toxicity; neurotoxicity; olfactory bulb; optimism; postiive attitude; progenitor; public health relevance; regenerate new tissue; regenerating damaged tissue; repair; repaired; research study; response; response to injury; stem cell population; stem cell therapy; stroke; subventricular zone; tissue regeneration; tool; traumatic brain damage",MRI Tracking of Stem Cell Migration During Brain Injury," Project narrative We are developing magnetic resonance micro-imaging approaches to label endogenous neural stem cells (NSCs) in the mouse brain, and to track their migrations at different developmental stages, from neonatal to adult, as well as in mice with brain injury, with and without administration of growth factors to enhance the response of the NSCs. The excitotoxic neuronal injury model is highly relevant to stroke and many human neurodevelopmental and neurodegenerative diseases. The ability to perform the imaging studies in mice will enable important future studies of NSC behaviors in genetically- engineered mouse models of many human brain diseases, and to use this vast resource of mouse models for testing drugs designed to enhance the therapeutic effects of the endogenous NSCs.",66490,MEDI,Medical Imaging Study Section,A1,1,253500,
7897453,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS067345-01A1,,NINDS:232500;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PHYSIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"PINTER, MARTIN J;",1900732;,1R21NS067345,02/01/2010,01/31/2012,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine; Action Potentials; Address; Axon; Axotomy; Cell Communication and Signaling; Cell Signaling; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Collection; Data; Dependency; Dependency (Psychology); Diffusion; Enabling Factors; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Factors, Enabling; Injury; Intracellular Communication and Signaling; Lead; Learning; Link; Mechanics; Mediating; Metric; Molecular; Mononitrogen Monoxide; Morphology; Motor; Motor Cell; Motor End-Plate; Motor Endplate; Motor Neurons; Muscle; Muscle Fibers; Muscle Tissue; Myotubes; NOS 1 protein; Natural regeneration; Neural Constitutive Nitric Oxide Synthase; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Pb element; Process; Production; Property; Property, LOINC Axis 2; Receptor Activation; Receptors, ACh; Receptors, Acetylcholine; Recovery; Regeneration; Rhabdomyocyte; Role; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Synapses; Synaptic; Testing; Work; axotomy response; base; biological signal transduction; electrical property; emotional dependency; endothelial cell derived relaxing factor; heavy metal Pb; heavy metal lead; innervation; insight; motoneuron; nNOS enzyme; nerve supply; neuronal nitric oxide synthase; novel; prevent; preventing; protein complex; public health relevance; receptor binding; receptor-mediated signaling; regenerate; regenerative; reinnervation; response; social role",Mechanisms of retrograde signaling between muscle and motor neurons," Narrative This work is focused on understanding mechanisms underlying retrograde signaling between muscle and motor neurons. Based on data we collected, e have developed the hypothesis that this signaling is initiated by motor endplate acetylcholine receptor activation. The purpose of the proposed studies is to test whether loss of this signaling underlies the motor neuron response to axotomy and to begin identification of molecular mechanisms in muscle that mediate retrograde signaling.",67345,SMI,Sensorimotor Integration Study Section,A1,1,232500,
7779144,R21,NS,1,,01/18/2010,11/30/2010,PA-06-181,1R21NS067513-01,,NINDS:180000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLOTTE,UNITED STATES,BIOLOGY,12,066300096,US,NC,282230001,UNIVERSITY OF NORTH CAROLINA CHARLOTTE,"BOST, KENNETH L;",1871416;,1R21NS067513,01/18/2010,11/30/2011,"APC; ATGN; Address; Animal Model; Animal Models and Related Studies; Antigen Presentation; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Assay; Autoantigens; Autoimmune Diseases; Autoimmune Responses; Autoimmune Status; Autoimmunity; Autologous Antigens; B blood cells; B-Cells; B-Lymphocytes; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Burkitt Herpesvirus; Burkitt Lymphoma Virus; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CNS Diseases; CNS disorder; CTLA-8; CTLA8; Cells; Cells, CD4; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communicable Diseases; Coupled; Critiques; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Demyelinations; Dendritic Cells; Development; Disease; Disorder; E-B Virus; EAE; EB virus; EBV; EBV Infections; Editorial Comment; Editorial Comment (PT); Employee Strikes; Encephalomyelitis; Encephalomyelitis, Allergic; Environmental Factor; Environmental Risk Factor; Epitopes; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus Infections; Event; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Exposure to; Funding; Gamma interferon; Generations; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; HHV-4; HSP; Heat shock proteins; Herpesviridae; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesviruses; Human Herpes Virus 4 Infections; Human Herpesvirus 4; Human Herpesvirus 4 Infections; IFN-Gamma; IFN-g; IFNG; IL-17; IL-17A; IL17; IL17 Protein; IL17A; Immunologic Accessory Cells; In Vitro; Infection; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infectious Mononucleosis Virus; Inflammatory; Inherited Predisposition; Inherited Susceptibility; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Laboratories; Lead; Link; MS (Multiple Sclerosis); Mammals, Mice; Mammals, Rodents; Mice; Modeling; Molecular Mimicries; Molecular Mimicry; Monocytes / Macrophages / APC; Multiple Sclerosis; Murine; Mus; Myelin; Myeloencephalitis; Nervous System, CNS; Neuraxis; Pathogenesis; Pathway interactions; Patients; Pb element; Peripheral; Population; Published Comment; Reporting; Research; Research Resources; Resources; Rodent; Rodent Model; Rodentia; Rodentias; Role; Sclerosis, Disseminated; Self-Antigens; Severities; Source; Stress Proteins; Strikes; Strikes, Employee; Symptoms; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Thymus-Dependent Lymphocytes; Time; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Veiled Cells; Viewpoint; Viewpoint (PT); Virus; Viruses, General; accessory cell; alpha-Crystallins; autoimmune disorder; autoimmune encephalomyelitis; base; cytokine; disease/disorder; environmental risk; experiment; experimental research; experimental study; gammaherpesvirus; genetic etiology; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; helper T cell; herpes virus; human herpesvirus 4 group; human subject; immunogen; in vivo; infectious organism; insular sclerosis; lFN-Gamma; macrophage; microbial; model organism; mouse model; pathogen; pathway; public health relevance; research study; response; self recognition (immune); social role; thymus derived lymphocyte",Induced Autoantigen Expression Exacerbates EAE," Using a mouse model of Experimental Autoimmune Encephalomyelitis, we propose to explore one possible mechanism which might contribute to the ""pathogen-induced exacerbation"" hypothesis of this autoimmune disease. Specifically, we will question whether an autoimmune response against crystallin alpha-beta following an infection might contribute to the exacerbation of clinical disease in this animal model of multiple sclerosis.",67513,ZRG1,Special Emphasis Panel,,1,180000,
7876353,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS069946-01,,NINDS:215831;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLOTTESVILLE,UNITED STATES,ENGINEERING (ALL TYPES),05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"KWON, INCHAN ;",10039513;,1R21NS069946,02/01/2010,01/31/2012,"ALS; Adeno-Associated Viruses; Affinity; Alanine; Alanine, L-Isomer; Amyloidosis; Amyotrophic Lateral Sclerosis; Behavior; Binding; Binding (Molecular Function); Candidate Disease Gene; Candidate Gene; Cells; CuZnSOD; Cytosol; Dependovirus; Development; Disease; Disorder; Erythrocuprein; Fluorescence; Future; Gehrig's Disease; Gene Delivery; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hemocuprein; High Throughput Assay; Human; Human, General; Idiopathic Parkinson Disease; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; L-Alanine; L-Valine; Lead; Lewy Body Parkinson Disease; Libraries; Lou Gehrig Disease; Mammalian Cell; Man (Taxonomy); Man, Modern; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Monitor; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Muscle, Skeletal; Muscle, Voluntary; Mutation; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pb element; Point Mutation; Prealbumin; Primary Parkinsonism; Proalbumin; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Reporting; Research; SOD; Screening procedure; Skeletal Muscle Tissue; Skeletal muscle structure; Superoxide Dismutase; Superoxide[{..}]superoxide oxidoreductase; Surface; Techniques; Technology; Testing; Therapeutic; Therapeutic Agents; Transthyretin; Valine; Variant; Variation; adeno associated virus group; amyloid disease; base; copper zinc superoxide dismutase; cytocuprein; design; designing; dimer; directed evolution; disease/disorder; gene product; genome mutation; heavy metal Pb; heavy metal lead; high throughput screening; monomer; mutant; nervous system disorder; neurological disease; neuronal; neurotoxic; programs; protein aggregation; public health relevance; screening; screenings; self assembly; success; therapeutic gene; vector",Exploiting Trans-Suppression to Arrest hSOD Aggregation in ALS," Project Narrative  Although the molecular mechanisms are still poorly understood, familial forms of amyotrophic lateral sclerosis (FALS) involves the formation of neurotoxic aggregates of human superoxide dismutase. The proposed research will lead to designed proteins that could be tested as gene therapeutic agents in future studies.",69946,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,,1,215831,
7874750,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS070029-01,,NINDS:223848;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"PAWLIKOWSKA, LUDMILA ;",9041925;,1R21NS070029,02/01/2010,01/31/2012,"21+ years old; Adult; Affect; Algorithms; American; Animal Model; Animal Models and Related Studies; Arteriovenous Angioma; Arteriovenous Hemangioma; Arteriovenous malformation; Biological; Biology; Bleeding; Blood; Blood Circulation; Blood Vessels; Bloodstream; Body Tissues; Brain; Brain Vascular Malformation; Brain hemorrhage; Candidate Disease Gene; Candidate Gene; Causality; Cavernous Malformation; Cell Fraction; Cells; Cerebrum; Cessation of life; Circulation; Clinical; Clinical Course of Disease; Clinical Management; Complex; DNA; DNA Resequencing; DNA lesion; DPC4; Death; Deoxyribonucleic Acid; Detection; Development; Disease; Disorder; Encephalon; Encephalons; Endothelial Cells; Etiology; Familial disease; Freezing; Gene variant; Genes; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Variation; Genetic defect; Goals; Health; Health Care Costs; Health Costs; Healthcare Costs; Hemorrhage; Hemorrhagic Diathesis; Hemorrhagic Disorders; Hereditary; Hereditary hemorrhagic telangiectasia; Human, Adult; Individual; Inherited; Intracranial Hemorrhages; Investigation; Lesion; MAD Homolog 4 Gene; MADH4; MADH4 gene; Molecular; Mothers Against Decapentaplegic Homolog 4; Mutate; Mutation; Mutation Detection; Nature; Nervous System, Brain; Neurofibrillary Tangles; Neurologic; Neurological; Osler-Rendu Disease; Osler-Weber-Rendu Disease; Pathogenesis; Patients; Population; Prevalence; Productivity; Protocol; Protocols documentation; Public Health; Racemose Angioma; Racemose Hemangioma; Resequencing; Reticuloendothelial System, Blood; Risk; Risk Estimate; Role; SMAD4; SMAD4/DPC4 Gene; Sampling; Shunt; Shunt Device; Somatic Mutation; Stratification; Syndrome; Technology; Testing; Tissue Sample; Tissues; Validation; Variation (Genetics); Vascular Diseases; Vascular Disorder; Vascular Malformation, Brain; Vascular malformations of the brain; Venous; Venous Angioma; Venous Malformation; Work; adult human (21+); adult youth; allelic variant; blood loss; blood vessel disorder; capillary bed; cost; disability; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; familial disorder; genome mutation; hemorrhagic stroke; improved; laser capture microdissection; loss of function mutation; malformation; model organism; neoplastic; neurofibrillary degeneration; neurofibrillary lesion; neurofibrillary pathology; next generation; novel; public health medicine (field); public health relevance; shunts; social role; tangle; vascular; young adult",Somatic mutation detection in brain AVM by massively high-throughput sequencing," PROJECT NARRATIVE Brain arteriovenous malformations (AVMs) are an important cause of hemorrhagic stroke in young adults, resulting in a considerable public health burden encompassing high healthcare costs and lost productivity. The causes of brain AVMs are poorly understood. We will investigate whether brain AVMs, both sporadic and those occurring in the familial disease Hereditary Hemorrhagic Telangiectasia, are caused by somatic mutations in the cells of the AVM lesion. This work will enhance understanding of the molecular mechanisms of AVM formation and hemorrhage, with the long-term goal of improving clinical management and developing new treatment approaches to lessen the negative burden AVMs on health.",70029,BINP,Brain Injury and Neurovascular Pathologies Study Section,,1,223848,
7873975,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS070049-01,,NINDS:235500;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"BAKER, KENNETH B;",8242142;,1R21NS070049,02/01/2010,01/31/2012,"Acquired brain injury; Address; Affect; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Area; Behavioral; Brain; Brain Injuries; Brain region; Cephalic; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Communication; Corpus Callosum; Corpus Callosums; Corticospinal Tracts; Cranial; Crossing Over; Crossing Over, Genetic; Data; Disease; Disinhibition; Disorder; Electric Stimulation; Electrical Stimulation; Electrodes; Encephalon; Encephalons; Evoked Potentials, Motor; Fiber; Forecast of outcome; Frequencies (time pattern); Frequency; General Population; General Public; Genetic Crossing Over; Goals; Hemipareses; Hemiplegia; Human; Human, General; Incidence; Infection; Internal Capsule; Ipsilateral; Lead; Lesion; MS (Multiple Sclerosis); Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Modeling; Monitor; Motor; Motor Cortex; Motor Evoked Potentials; Multiple Sclerosis; Nervous System, Brain; Neurologic; Neurological; Outcome; Outcome Measure; PBO; Pathway interactions; Patients; Pb element; Performance; Physical Health Services / Rehabilitation; Placebos; Prevalence; Primates; Prognosis; Recovery; Recovery of Function; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Research; Route; Sclerosis, Disseminated; Secondary to; Sham Treatment; Side; Specific qualifier value; Specified; Stroke; Testing; Time; Training; Transcranial magnetic stimulation; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Work; base; behavioral disinhibition; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; clinical applicability; clinical application; corticofugal fiber; disease/disorder; economic cost; experiment; experimental research; experimental study; functional recovery; heavy metal Pb; heavy metal lead; hemiparetic; improved; indexing; insular sclerosis; intervention design; model organism; motor control; motor deficit; neural control; neural regulation; neuroregulation; neurorestoration; neurorestorative; non-human primate; nonhuman primate; nonsister chromatid exchange; outcome forecast; pathway; post stroke; poststroke; pre-clinical; preclinical; primary outcome; public health relevance; rehabilitative; research study; response; sham therapy; stroke; substantia alba; therapy design; traumatic brain damage; treatment design; tumor; white matter",Modulation of interhemispheric inhibition for the treatment of subcortical stroke," PROJECT NARRATIVE The goal of this study is to determine whether electrical stimulation of certain brain regions can be used to improve recovery in patients with motor deficits following stroke or other types of brain damage. In some cases of subcortical stroke, a type of stroke where the damage occurs deep in the brain, there is limited opportunity for recovery as the fibers that connect the brain to the body have been destroyed. There is evidence that the opposite side of the brain may have a latent ability to assume motor function over the side of the body that is impaired, however this ability is limited by on-going interactions that occur between the two sides of the brain by way of the corpus callosum. To address this, we propose to disrupt this communication between the two sides of the brain by electrically stimulating the corpus callosum in an animal model of stroke. The effect of stimulation on both motor recovery and the motor representation of the side of the body affected by the stroke will be monitored over time. New treatments that can further enhance recovery of function after strokes are necessary and, if proven efficacious, will have a dramatic impact given the combined high incidence and prevalence of neurological deficits and the high economic cost from stroke in the general population.",70049,ANIE,Acute Neural Injury and Epilepsy Study Section,,1,235500,
7874774,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS070064-01,,NINDS:237992;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,CHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"DU BOIS, JUSTIN ;",8912994;,1R21NS070064,02/01/2010,01/31/2012,"1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; 1-propyl-2',6'-pipecoloxylidide; 1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS-(3aalpha,4alpha,10aR*))-; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide; 2-2EtN-2MePhAcN; 2-Diethylamino-2',6'-acetoxylidide; 21+ years old; Acute; Adult; Adverse effects; Amino Acids; Analgesia, Congenital; Analgesics, Opioid; Anesthesia; Anesthesia procedures; Antibodies; Ataxia; Ataxy; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Buccal Cavity; Bupivacaine; Causality; Cavitas Oris; Cell Communication and Signaling; Cell Signaling; Cells; Central Nervous System; Characteristics; Chronic; Clinical; Closure by Ligation; Combining Site; Communication; Conduction-Blocking Anesthetics; Confusion; Confusional State; Congenital Pain Indifferences; Congenital Pain Insensitivity; Contin, MS; Coordination Impairment; Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-; Dependence; Development; Dihydrocodeinone; Dihydromorphinone; Dilaudid; Dilaudid HP; Dimorphone; Drowsiness; Drowsinesses; Drug Design; Drug Prescribing; Drug Prescriptions; Drug or chemical Tissue Distribution; Drugs; Du Pont Brand of Hydrocodone Tartrate; Dyssynergia; Electrophysiology; Electrophysiology (science); Engineering; Engineerings; Esthesia; Etiology; Evaluation; Family; Fentanyl; Fentyl; Generations; Genes; Genetics-Mutagenesis; Goals; Gonyaulax Toxin; Head and Neck, Buccal Cavity; Human, Adult; Hycodan; Hycodan brand of hydrocodone bitartrate; Hycon; Hydrocodone; Hydromorphon; Hydromorphone; Hydrostat; Hymorphan; Hyperalgesia; Hyperalgesic Sensations; Individual; Infumorph; Injection of therapeutic agent; Injections; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Ion Channel; Ion Channels, Sodium; Ionic Channels; Ions; Isoforms; Kadian; Laudacon; Laudicon; Lead; Lidocaine; Ligation; Lignocaine; Link; Local Anesthetics; Loss of Sensation; MSir; Macrogols; Macromolecular Structure; Maleimides; Mediating; Medication; Medicine; Membrane Channels; Mental Confusion; Mercaptans; Mercapto Compounds; Methods and Techniques; Methods, Other; Mitilotoxin; Moab, Clinical Treatment; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Structure; Molecular Weight; Monoclonal Antibodies; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-; Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-; Morphine; Mouth; Mutagenesis; NIDA; National Institute of Drug Abuse; Nausea; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Nociception; Novolauden; Numbness; Omega-diethylamino-2,6-dimethylacetanilide; Opioid; Opioid Analgesics; Opioid Receptor; Oral cavity; Oramorph; Oramorph SR; PEG; Pain; Pain Control; Pain Indifference, Congenital; Pain Insensitivity, Congenital; Pain Therapy; Pain management; Painful; Pakistan; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Phentanyl; Physiology; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polyoxyethylenes; Post-Operative; Postoperative; Postoperative Period; Prescriptions, Drug; Programs (PT); Programs [Publication Type]; Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)-; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Reactive Site; Receptors, Opiate; Recombinants; Respiratory Depression; Risk; Roxanol; STX; Saxitonin; Saxitoxin; Science of Medicine; Sensation; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sodium Channel; Somnolence; Statex SR; Sulfhydryl Compounds; Surface; Techniques; Therapeutic Studies; Therapy Research; Thiols; Tissue Distribution; Tramadol; Transmembrane Protein; Treatment Side Effects; United States; V (voltage); Variant; Variation; Ventilatory Depression; abused drugs; addiction; adult human (21+); aminoacid; antibody conjugate; antibody engineering; biological signal transduction; chemotherapy; chronic neuropathic pain; chronic pain; chronic painful condition; congenital hyposensitivity to pain; congenital insensitivity to pain; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug of abuse; drug/agent; drugs abused; drugs of abuse; efficacy testing; extracellular; familial hyposensitivity to pain; familial insensitivity to pain; functional group; gene product; heavy metal Pb; heavy metal lead; hyperalgia; inhibitor; inhibitor/antagonist; interest; loss of function mutation; neuronal; neuronal excitability; new therapeutics; next generation; next generation therapeutics; nociceptive; novel therapeutics; programs; protein complex; public health relevance; ropivacaine; side effect; small molecule; success; sulfhydryl group; therapy adverse effect; tool; treatment adverse effect; voltage; voltage clamp",Saxitoxin-Antibody Conjugates as Tools for Na+ Ion Channel Study and Therapeutics," PROJECT NARRATIVE Opioid analgesics, such as morphine, cause a range of side effects and are subject to abuse, yet remain the most frequently prescribed drugs for the treatment of pain. We wish to develop new pharmacological tools that act by intervening with specific pain-producing signals in order to gain a deeper understanding of the etiology of pain. Results from these studies could help guide the development of next-generation therapies for pain management.",70064,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,1,237992,
7875911,R21,NS,1,,02/01/2010,01/31/2011,PA-07-306,1R21NS070084-01,,NINDS:231000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NEUROLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BRENNAN, KEVIN CHRISTOPHER;",8724587;,1R21NS070084,02/01/2010,01/31/2012,"1,3-Dimethyl-5-aminoadamantane; 1-Amino-3,5-dimethyladamantane; Accounting; Acute; Address; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Attenuated; Auras; Behavior; Benign; Blood Vessels; Body Tissues; Bone structure of cranium; Brain; CK1; CSNK1A1; CSNK1A1 gene; Calcium Channel; Calcium Channel Antagonist Receptor; Casein Kinase 1; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chemotherapy-Hormones/Steroids; Chronic; Classic Migraine; Classical Migraine; Clinical; Complement; Complement Proteins; Cranium; Data; Death; Disease; Disorder; Dose; Drugs; Effects, Longterm; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Endocrine Gland Secretion; Endocrine Therapy; Event; Familial Hemiplegic Migraine; Family; Female; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic defect; Gonadal Hormones; Gonadal Steroid Hormones; HLCDGP1; Headache, Migraine; Hemoglobin; Histology; Hormonal; Hormonal Therapy; Hormones; Human; Human, General; Hypoxia; Hypoxic; Image; Infarction; Inherited Predisposition; Inherited Susceptibility; Ion Channels, Calcium; Ischemia; Leao depression; Link; Long-Term Effects; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medication; Memantin; Memantine; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Migraine; Migraine Variants; Migraine with Aura; Migraine with Typical Aura; Modeling; Motor; Murine; Mus; Mutation; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology / Electrophysiology; Oxygen Deficiency; PRO2975; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Predisposition; Preparation; Prevention Measures; Preventive; Prophylactic treatment; Prophylaxis; Protein Kinase CK1; Protein Kinase CKI; Protocol; Protocols documentation; Public Health; Receptors, Calcium Channel Blocker; Recommendation; Recovery; Recovery of Function; Risk; Sensory; Severities; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Skull; Spreading Cortical Depression; Stroke; Surface; Susceptibility; Techniques; Testing; Therapeutic Hormone; Time; Tissues; Transgenic Animals; Transgenic Mice; Transgenic Model; Transgenic Organisms; Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl-; VDCC; Variants, Migraine; Vascular Accident, Brain; Voltage-Dependent Calcium Channels; Wild Type Mouse; Woman; Work; base; brain attack; casein kinase I; cerebral vascular accident; cranium; disease/disorder; drug/agent; experiment; experimental research; experimental study; functional recovery; gender difference; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome mutation; gonadal steroids; high risk; hormone therapy; imaging; in vivo; infarct; innovate; innovation; innovative; male; men; men's; model organism; nervous system disorder; neurological disease; neuronal; novel; public health medicine (field); public health relevance; research study; response; sex; sex steroid; sexual dimorphism (noncellular); stroke; stroke recovery; transgenic; vascular",Investigating the basic mechanisms linking migraine and stroke," RELEVANCE TO PUBLIC HEALTH This proposal directly addresses a serious clinical problem with techniques that should provide both mechanistically specific and clinically-actionable information. Our experiments should advance the understanding of both migraine and stroke, especially the hormonal and genetic factors that increase risks in women, and in doing so generate concrete recommendations for the treatment of at-risk patients.",70084,ANIE,Acute Neural Injury and Epilepsy Study Section,,1,231000,
7876141,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS070153-01,,NINDS:193125;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"SU, HUA ;",8133807;,1R21NS070153,02/01/2010,01/31/2012,"AAV vector; ANG1; ANGPT1; Adverse effects; Angiogenic Factor; Angiopoietin-1; Arterial Obstruction; Arterial Occlusion; Artery Obstruction; Attenuated; Blood - brain barrier anatomy; Blood Vessels; Blood flow; Blood-Brain Barrier; Body Tissues; Brain; Capsid; Cerebrum; Cessation of life; Clinical; Critical Illness; Critically Ill; Custom; Death; Development; Diffuse; Distal; Dose; Encephalon; Encephalons; Extravasation; Factor, Angiogenesis; Feasibility Studies; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Genes; Genes, LacZ; Genetic Intervention; Goals; Growth; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Hemato-Encephalic Barrier; Hypoxia; Hypoxic; IV drip; In Vitro; Injection of therapeutic agent; Injections; Injury; Intervention, Genetic; Intravenous; Intravenous Drip; Intravenous Infusion; Intraventricular; Ischemic Brain Injury; Ischemic Heart; Ischemic Heart Disease; Ischemic Penumbra; Ischemic Stroke; Ischemic myocardium; LacZ; LacZ Genes; Lead; Leakage; Mammals, Mice; Mediating; Methods; Methods and Techniques; Methods, Other; Mice; Middle Cerebral Artery Occlusion; Modeling; Molecular Biology, Gene Therapy; Murine; Mus; Myelopathy, Traumatic; Myocardial Ischemia; Names; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Injury; Neurons; Normal Tissue; Normal tissue morphology; Occlusion, Middle Cerebral Artery; Outcome; Oxygen Deficiency; Patients; Pb element; Penetration; Pilot Projects; Procedures; Proteins; R01 Mechanism; R01 Program; RNA, Small Interfering; RPG; Recovery; Recovery of Function; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Response Elements; Scheme; Serotyping; Small Interfering RNA; Solid; Spillage; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Tail; Techniques; Technology; Testing; Therapeutic; Therapeutic Effect; Therapy, DNA; Tissue Growth; Tissues; Translations; Treatment Side Effects; VEGFs; Vascular Endothelial Growth Factors; Vascular blood supply; Vegf; Veins; Work; adeno-associated viral vector; adeno-associated virus vector; angiogenesis; artery occlusion; base; blood supply; brain tissue; clinical applicability; clinical application; coat (nonenveloped virus); design; designing; dosage; drip infusion; experiment; experimental research; experimental study; functional recovery; gene product; gene therapy; genetic therapy; heart ischemia; heavy metal Pb; heavy metal lead; hypoxia inducible factor 1; improved; injury response; innovate; innovation; innovative; intravenous administration; intravenous injection; ischemic brain damage; myocardial ischemia/hypoxia; myocardium ischemia; neurobehavioral; neuron injury; neuronal; neuroprotection; neurorestoration; neurorestorative; novel; ontogeny; pilot study; prevent; preventing; public health relevance; research study; response; response to injury; restoration; siRNA; side effect; stroke therapy; therapeutic protein; therapy adverse effect; tool; transgene expression; treatment adverse effect; vascular; vascular supply; vector; vein infusion",Targeted Gene Expression in Ischemic Brain by Intravenous Delivery," Project Narrative This project will develop a new method to induce new functional small blood vessels in the brain where the blood supply is insufficient. As result, increased blood flow will protect neurons from death.",70153,BINP,Brain Injury and Neurovascular Pathologies Study Section,,1,193125,
7877507,R21,NS,1,,01/19/2010,12/31/2010,PA-09-164,1R21NS070175-01,,NINDS:231375;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW BRUNSWICK,UNITED STATES,OTHER BASIC SCIENCES,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"GRUMET, MARTIN H;",1886517;,1R21NS070175,01/19/2010,12/31/2011,"Acute; Alginates; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Biochemical; Bioreactors; Body Tissues; Bone Marrow; CAPS; Capsules; Cell Density; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell Survival; Cell Therapy; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cicatrix; Common Rat Strains; Cyst; Data; Density, Cell; Disease; Disorder; Early treatment; Encapsulated; Environment; Foundations; Freezing; Gliosis; Goals; Histologic; Histologically; Home; Home environment; Human; Human, General; INFLM; Immune; Immunomodulation; Implant; In Vitro; Infiltration; Inflammation; Inflammatory; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Injury; Location; Lumbar Puncture; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Microscopic; Modeling; Molecular; Mother Cells; Myelopathy, Traumatic; Nervous; Neural Stem Cell; Operation; Operative Procedures; Operative Surgical Procedures; Procedures; Progenitor Cell Transplantation; Progenitor Cells; Proteins; Protocol; Protocols documentation; RNA, Messenger; Rat; Rattus; Reaction; Recovery; Recovery of Function; Relative; Relative (related person); Reticuloendothelial System, Bone Marrow; Scars; Site; Spinal Cord; Spinal Cord Contusions; Spinal Cord Trauma; Spinal Puncture; Spinal Tap; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stem Cell Transplantation; Stem cell transplant; Stem cells; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Testing; Therapy, Cell; Time; Tissue Extracts; Tissues; Transplantation; Variant; Variation; axon regeneration; axonal regeneration; capsule (pharmacologic); cell bank; cell type; cell-based therapy; clinical relevance; clinically relevant; combinatorial; cytokine; disease/disorder; experiment; experimental research; experimental study; functional recovery; gene product; immune modulation; immunologic reactivity control; immunoregulation; implantation; mRNA; model organism; nerve stem cell; neural; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; novel; paracrine; poly-L-lysine alginate; precursor cell; prevent; preventing; protein expression; public health relevance; relating to nervous system; release factor; research study; response; stem; surgery; transplant",Lumbar Puncture Delivery of MSC & Function in Spinal Cord Injury,  We will investigate the anti-inflammatory effects of human and rat bone marrow mesenchymal stem cells (MSC) for clinically-relevant treatments of acute spinal cord injury (SCI) by introducing these cells through less invasive procedures that do not require surgery but resemble a spinal tap. We will also test enclosing the cells in alginate capsules that prevent them from getting rejected. The combined approach may open widely applicable and less invasive treatments for early intervention after spinal cord injury with partially matched MSC that can be stored in frozen cell banks.,70175,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,1,231375,
7884874,R21,NS,1,,02/01/2010,01/31/2011,PA-09-164,1R21NS070269-01,,NINDS:189624;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"ZHUANG, XIAOXI ;",6846989;,1R21NS070269,02/01/2010,01/31/2012,"3'5'-cyclic ester of AMP; 3,4-Dihydroxyphenethylamine; 3,5 cyclic AMP synthetase; 4-(2-Aminoethyl)-1,2-benzenediol; AC5 enzyme; ACI (cyclase); ATP pyrophosphate-lyase (cyclizing); Abnormal Movements; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Animal Model; Animal Models and Related Studies; Blood Coagulation Factor IV; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Signaling; Cells; Coagulation Factor IV; Corpus Striatum; Corpus striatum structure; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; D1 receptor; D2 receptor; DA Neuron; DRD2; DRD2 Receptor; Development; Dopamine; Dopamine Antagonists; Dopamine D1 Receptor; Dopamine D2 Receptor; Dopamine Receptor Antagonists; Dopamine neuron; Dopaminergic Antagonists; Dose; Dyskinesia Syndromes; Dyskinesias; Dyskinetic syndrome; Examination of gait; Factor IV; Feedback; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gait Analysis; Glutamates; Goals; Hydroxytyramine; Idiopathic Parkinson Disease; Intracellular Communication and Signaling; Isoforms; L-Glutamate; Lesion; Lewy Body Parkinson Disease; Locomotor Activity; Mammals, Mice; Mice; Mice, Transgenic; Motor; Motor Activity; Motor output; Movement Disorder Syndromes; Movement Disorders; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neuron Degeneration; Neurons; PKA; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Phenotype; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Primary Parkinsonism; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase A; Receptor Cell; Replacement Therapy; Reserpine; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Striate Body; Striatum; Substantia Nigra; Substantia nigra structure; Symptoms; Testing; Transgenic Mice; Transgenic Organisms; Work; Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-; adenosine 3'5' monophosphate; adenylcyclase; adenylyl cyclase 1; adenylyl cyclase type 5; adenylyl cyclase type I; adenylyl cyclase type V; base; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; dopaminergic neuron; effective therapy; gait examination; high risk; model organism; motor control; motor impairment; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; overexpression; pathway; public health relevance; striatal; transgenic",Animal models of dopamine-independent motor control, Project Narrative  We will generate transgenic mice with dopamine-independent motor control. Positive results will provide proof of principle and will guide the development of non- dopamine replacement based therapies for Parkinson's disease.,70269,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,1,189624,
7917975,R21,NS,1,,01/19/2010,12/31/2010,PA-07-035,1R21NS070580-01,,NINDS:225439;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"WASCHEK, JAMES A;",1904128;,1R21NS070580,01/19/2010,12/31/2011,"0-11 years old; Acceleration; Acquired brain injury; Affect; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Area; Behavioral; Birth of Full-Term Infant; Birth of Full-Term Newborn; Blood Vessels; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Cell Death, Programmed; Cells; Cerebral Palsy; Cessation of life; Child; Child Youth; Children (0-21); Cognitive; Communicable Diseases; DISSEC; Data; Death; Defect; Development; Diffuse; Disease; Disorder; Dissection; Encephalon; Encephalons; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Family; Fullterm Birth; Gestation; Human; Human, Child; Human, General; Hypoxia-Ischemia, Brain; INFLM; In element; Incidence; Indium; Infant; Infant, Premature; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Inflammatory; Injection of therapeutic agent; Injections; Injections, Subcutaneous; Injury; Knock-out; Knockout; Knockout Mice; LPS; Label; Light; Lipopolysaccharides; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mental Retardation; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modality; Modeling; Molecular Target; Motor; Murine; Mus; Natural regeneration; Nature; Necrosis; Necrotic; Neonatal; Nervous System, Brain; Neurologic; Neurological; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Pathogenesis; Perinatal; Perinatal Care; Peripheral; Periventricular white matter injury; Photoradiation; Population; Preclinical Testing; Pregnancy; Premature Birth; Premature Infant; Preterm Birth; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Regeneration; Risk; Rupture; Societies; Staging; Subcutaneous Injections; Survivors; System; System, LOINC Axis 4; Term Birth; Testing; Therapeutic Agents; Therapeutic Intervention; Time; Transgenic Mice; Transgenic Organisms; astrogliosis; brain damage; brain lesion (from injury); cell type; children; disability; disease/disorder; hypoxia ischemia; improved; intervention therapy; model organism; mouse model; myelination; neuroinflammation; oligodendrocyte precursor; postnatal; premature baby; premature childbirth; premature delivery; premature infant human; preterm baby; preterm delivery; preterm infant; preterm infant human; preterm neonate; progenitor; public health relevance; pup; regenerate; response; substantia alba; tool; transgenic; vascular; white matter; white matter damage; white matter injury; youngster",Mechanisms of inflammation-associated brain injury: transgenic dissection," Project Narrative Brain injury, including cerebral palsy and mental retardation is associated with premature birth and results in significant suffering to the afflicted and their families and is a major financial burden to society. As epidemiological studies indicate that a likely cause for this condition is maternal infection, we have established a mouse model which recapitulates the disease, and propose to use the model to determine how maternal infection leads to these defects. The proposed studies are expected to reveal new strategies that will allow the development of both predictors that help identify infants at risk and therapeutic agents reduce the consequences in afflicted children.",70580,CMBG,Cellular and Molecular Biology of Glia Study Section,,1,225439,
7762499,R21,RR,1,,01/01/2010,12/31/2010,RR-09-001,1R21RR025816-01A1,,NCRR:195968;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NEW YORK,UNITED STATES,ENGINEERING (ALL TYPES),15,049179401,US,NY,100277003,COLUMBIA UNIV NEW YORK MORNINGSIDE,"LIN, QIAO ;",8559035;,1R21RR025816,01/01/2010,12/31/2012,"Address; Affinity; Affinity Chromatography; Binding; Binding (Molecular Function); Biological; Biomedical Research; Cells; Characteristics; Chromatography, Affinity; Complex Mixtures; DNA; Deoxyribonucleic Acid; Dependence; Development; Diagnostic; Disease; Disorder; Engineering; Engineerings; Equilibrium; Evolution; Exhibits; In Vitro; Interdisciplinary Research; Interdisciplinary Study; Kinetic; Kinetics; Libraries; Ligands; Mechanics; Medicine; Methods; Methods and Techniques; Methods, Other; Microfluidic; Microfluidics; Modeling; Molecular Interaction; Multidisciplinary Collaboration; Multidisciplinary Research; Nucleic Acids; Oligo; Oligonucleotides; PCR; Polymerase Chain Reaction; Principal Investigator; Procedures; Property; Property, LOINC Axis 2; Proteins; Public Health; Research; Science of Medicine; Stimulus; Study, Interdisciplinary; System; System, LOINC Axis 4; Techniques; Technology; Temperature; Thermodynamic; Thermodynamics; Time; Universities; Validation; Work; affinity purification; aptamer; balance; balance function; base; disease/disorder; drug discovery; gene product; instrument; microchip; nucleic acid structure; prototype; public health medicine (field); public health relevance; small molecule",Microfluidic Selection of Aptamers for Biological Purification Applications," PROJECT NARRATIVE Microfluidic Selection of Aptamers for Biological Purification Applications  Principal Investigator: Qiao Lin, Columbia University This research will pursue proof-of-concept demonstration of a microfluidic system that integrates all steps of the method of systematic evolution of ligands by exponential enrichment (SELEX). The system will allow automated development of aptamers with predefined temperature-dependent binding characteristics for analyte purification applications. It is relevant to public health because it will provide a platform for selecting aptamers for affinity purification of analytes such as proteins, small molecules and cells involved in biomedical research on diseases. In addition, this system could also be used to develop aptamers for applications to target validation, drug discovery, diagnostics, and therapy.",25816,ZRR1,Special Emphasis Panel,A1,1,195968,
7762675,R21,RR,1,,02/01/2010,12/31/2010,RR-09-001,1R21RR026228-01,,NCRR:196599;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,OKLAHOMA CITY,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"RUTEL, ISAAC B;",9741160;,1R21RR026228,02/01/2010,12/31/2011,"Affect; Ag element; Aging; Animals; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Area; Atrial Fibrillation; Auricular Fibrillation; Automobile Driving; Bacteria; Benefits and Risks; Blood; Body Tissues; Bypass; Care, Health; Cavia; Cell Coat; Cells; Clinical; Collaborations; Computer Programs; Computer software; Costs and Benefits; Development; Devices; Diabetic Retinopathy; Diffusion; Disease by Site; Disorder by Site; Dose; Drivings, Automobile; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; ENT; Ear; Ear structure; Ear, Internal; Evaluation; Eye; Eyeball; Face; Formulation; Formulations, Drug; Gamma Camera Imaging; Gel; Glycocalyx; Government; Guinea Pigs; HOSP; Hand; Health Care Costs; Health Costs; Healthcare; Healthcare Costs; Hearing Loss, Sensorineural; Heart; Hospitalization; Hospitals; Human; Human, General; Image Analyses; Image Analysis; In Vitro; Infection; Infectious Skin Diseases; Injection of therapeutic agent; Injections; Instrumentation, Other; Killings; Labyrinth; Liquid substance; MRSA; Magnetism; Mammals, Guinea Pigs; Man (Taxonomy); Man, Modern; Medication; Medicine; Membrane; Methicillin Resistance; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Methods; Methods and Techniques; Methods, Other; Microbe; Microbial Biofilms; Miscellaneous Antibiotic; Modeling; Movement; Muscle; Muscle Tissue; Nanoscale Science; Nanotechnology; Needles; Nerve; Nervous; Ophthalmologist; Otolaryngologist; Paint; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Polymers; Population; Post-Operative; Postoperative; Postoperative Period; Prevention; Protocols, Treatment; RGM; ROC Analysis; Radioactive Isotopes; Radioisotopes; Radionuclide Imaging; Radionuclides; Records Controls; Recovery; Regimen; Research; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Blood; Retina; Retinal; Retinal Diseases; Retinal Disorder; Round Window; Safety; Scanning, Radioisotope; Science of Medicine; Scintigraphy; Senescence; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Side; Silver; Site; Skin; Skin Diseases, Infectious; Software; Solutions; Structure of cochlear window; Surface; Syringes; System; System, LOINC Axis 4; Techniques; Technology; Testing; Therapeutic; Tissues; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States; Validation; Viscosity; Visual; Vitreous humor; Work; advanced simulation; antibiotic resistant; biofilm; body movement; clinical applicability; clinical application; computer program/software; cost effective; design; designing; diabetic; driving; drug/agent; effective therapy; experiment; experimental research; experimental study; facial; fenestra cochleae; ferrosoferric oxide, magnetite; fluid; image evaluation; improved; in vivo; inner ear; instrument; instrumentation; interest; liquid; magnetic; magnetic field; magnetite; magnetite ferrosoferric oxide; membrane structure; methicillin resistant; methicillin resistant Staphylococcus aureus (organism); nano composite; nano medicine; nano particle; nano scale Science; nano tech; nano technology; nano therapy; nanocomposite; nanomedicine; nanoparticle; nanotech; nanotherapy; novel; open wound; particle; public health relevance; radionuclide imaging/scanning; radionuclide scanning; research study; retina disease; retina disorder; retinopathy; risk benefit ratio; senescent; site targeted delivery; skin infection; targeted delivery",Magnetic Injector for Targeted Delivery of Therapeutics," We propose to develop and optimize a novel instrument to inject or push magnetically active nanoparticle therapies into medically affected tissues. The instrument will not only enhance current nano-therapy practices, but provide a means to new therapies that until now have been impractical or dangerous due to the size of magnets required to implement them. We expect the instrument to work (with properly loaded nanoparticles) to treat sensorineural hearing loss, postoperative atrial fibrillation, MRSA infections, and diabetic retinopathies.",26228,ZRR1,Special Emphasis Panel,,1,196599,
7763336,R21,RR,1,,01/20/2010,01/19/2011,RR-09-001,1R21RR026253-01,,NCRR:177256;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,RIVERSIDE,UNITED STATES,ENGINEERING (ALL TYPES),07,627797426,US,CA,92521,UNIVERSITY OF CALIFORNIA RIVERSIDE,"BALLAS, CHRISTOPHER BRADLEY;RAO, MASARU PALAKURTHI (contact);",8707318 (contact);8780358;,1R21RR026253,01/20/2010,01/19/2013,"Address; Advanced Instrumentation; Area; Arts; Au element; Automation; Biological; Blood Precursor Cell; Cancer, Oncology; Cell Therapy; Cells; Clinical; Clinical Research; Clinical Study; Communities; Computer Instrumentation; Computers; Computers and Advanced Instrumentation; Development; Device or Instrument Development; Devices; Discipline; Disease; Disorder; Drug Evaluation, Preclinical; Drug Screening; Elements; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Future; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic; Genetic Condition; Genetic Diseases; Genetic Intervention; Goals; Gold; Health; Hematology; Hematopoietic stem cells; Hereditary Disease; Human; Human, General; Injection of therapeutic agent; Injections; Instrumentation, Other; Intervention, Genetic; Investigation; Investigators; Lead; Libraries; Life; Man (Taxonomy); Man, Modern; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microfabrication; Microinjections; Mission; Modification; Molecular Biology, Gene Therapy; Molecular Disease; Operation; Operative Procedures; Operative Surgical Procedures; Outcome Study; Pb element; Performance; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Preclinical Drug Evaluation; Process; Production; Progenitor Cells, Hematopoietic; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reliance; Research; Research Personnel; Researchers; Risk; Robotics; Safety; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Site; Solid; Speed; Speed (motion); Staging; Study, Outcome; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Technology; Testing; Therapeutic; Therapy, Cell; Therapy, DNA; Time; Transfection; Transgenic Animals; Transgenic Organisms; Translations; Validation; Viral Vector; base; biological systems; cell engineering; cell type; cell-based therapy; cellular engineering; clinical applicability; clinical application; cost; design; designing; device development; disease control; disease/disorder; disorder control; drug discovery; gene therapy; genetic disorder; genetic therapy; heavy metal Pb; heavy metal lead; hereditary disorder; improved; innovate; innovation; innovative; instrument; instrument development; instrumentation; novel; oncology; prevent; preventing; prototype; public health relevance; screening; screenings; success; surgery; transgenic",Ultrahigh throughput cellular manipulation via massively parallel microinjection,"  The proposed effort seeks to develop innovative instrumentation for cellular manipulation that holds potential for opening new avenues of biological investigation at larger scales than previously possible across many disciplines. It may also enable realization of novel techniques for curing genetic diseases and engineering cellular therapies for other diseases. As such, the relevance of the proposed effort to NIH's mission to advance understanding of biological systems, improve control of disease, and enhance health is apparent.",26253,ZRR1,Special Emphasis Panel,,1,177256,
7867760,R21,RR,1,,01/15/2010,12/31/2010,PA-07-336,1R21RR030264-01,,NCRR:164226;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,FARMINGTON,UNITED STATES,ANATOMY/CELL BIOLOGY,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"PELUSO, JOHN J;",1867074;,1R21RR030264,01/15/2010,12/31/2011,"2 Dimensional Gel Electrophoresis; Agonist; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Binding Proteins; Blastocyst Implantation, natural; Body Tissues; Cancer of the Ovary; Cancers; Cannot achieve a pregnancy; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Survival; Cell Viability; CellLine; Cells; Chemotherapy-Hormones/Steroids; Cholest-5-en-3-ol (3beta)-; Cholesterol; Corpus Luteum Hormone; Data; Decidual Cell Reactions; Delta4-pregnene-3,20-dione; Development; Difficulty conceiving; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Embryo Implantation; Endocrine Gland Secretion; Endometrial; Endometrium; Epithelial Cell Proliferation; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrous Cycle; Fecundability; Fecundity; Female; Fertility; Gene Expression; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Female, Ovary; Genital System, Female, Uterus; Gestation; Goals; Gonadotropins; Grant; Granulosa-Luteal Cells; Granulosa-Lutein Cells; Growth; Histocompatibility; Hormones; Human; Human, General; Immune Precipitation; Immune system; Immunoprecipitation; Implantation, Blastocyst; In Vitro; Infertility; Investigators; Knockout Mice; Lead; Length of Life; Ligand Binding Protein; Ligands; Longevity; Luteal Cells; Luteal Cells, Large; Lutein Cells; M Phase; M phase (cell cycle); Malignant Neoplasm of the Uterus; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant Tumor of the Uterus; Malignant Uterine Neoplasm; Malignant Uterine Tumor; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Mesenchymal; Mice; Mice, Knock-out; Mice, Knockout; Mitosis; Mitosis Stage; Molecular Interaction; Monitor; Mouse Strains; Murine; Mus; Mutation; Nidation; Nuclear; Null Mouse; Ovarian; Ovarian Failure, Premature; Ovary; Ovulation; Ovum Implantation; Pb element; Physiologic; Physiological; Play; Pregn-4-ene-3,20-dione; Pregnancy; Pregnenedione; Premature Ovarian Failure; Progesterone; Progesterone Receptors; Protein Binding; Proteomics; Receptor Protein; Receptors, Progesterone; Receptors, Progestin; Reproduction; Reproductive Physiology; Reproductive Process; Research Personnel; Researchers; Role; Site; Staging; Steroid Compound; Steroids; Stromal Cells; Technology; Testing; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Tissue Compatibility; Tissue Growth; Tissues; Uterine Cancer; Uterus; Uterus Cancer; base; body system, allergic/immunologic; cultured cell line; decidualization; embryo/fetus; genome mutation; granulosa cell; heavy metal Pb; heavy metal lead; implantation; in vivo; infertile; life span; lifespan; malignancy; membrane structure; natural Blastocyst Implantation; neoplasm/cancer; ontogeny; organ system, allergic/immunologic; ovarian cancer; progesterone receptor; public health relevance; receptor; reproductive; reproductive axis; reproductive function; social role; transcription factor; unable to bear children; womb",PGRMC1 function in female reproductive physiology," Principle Investigator: Peluso, John, J Project Narrative Progesterone (P4) is an essential hormone that regulates the entire female reproductive process. Our recent in vitro studies of ovarian and uterine cells have revealed that some actions of P4 such as granulosa/luteal cell viability, P4 synthesis and uterine stromal cell differentiation are mediated in part through the P4 binding protein, Progesterone Receptor Membrane Component-1 (PGRMC1). In this grant we will conclusively determine the role of PGRMC1 by generating a conditional knockout mouse and then monitoring the effects of depleting PGRMC1 on 1) female fertility, 2) ovarian function and 3) uterine function. If successful, the proposed studies could lead to the development of a new class of P4 antagonists and agonists that could be used to treat human infertility and potentially ovarian and uterine cancers.",30264,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,1,164226,
7763447,R24,DK,1,Y,01/12/2010,12/31/2010,PAR-08-181,1R24DK084969-01,,NIDDK:573000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,,53,020520466,US,CA,92037,BURNHAM INSTITUTE FOR MEDICAL RESEARCH,"BODMER, ROLF ;GULICK, TOD ;KELLY, DANIEL PATRICK (contact);ROTH, GREGORY ;",1865843 (contact);1874439;1886788;8333469;,1R24DK084969,01/12/2010,12/31/2010,"Address; Adipocytes; Adipose Cell; Adipose tissue; Automobile Driving; Bio-Informatics; Bioinformatics; Biology; Body Tissues; Cell Communication and Signaling; Cell Signaling; Cells; Chemistry; Chemistry, Pharmaceutical; Chronic; Complex; Data; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Discipline; Drivings, Automobile; Dysfunction; Engineering; Engineerings; Epidemic; Event; Fat Cells; Fatty Acids; Fatty Tissue; Functional disorder; Genes, Regulator; Genetic; Glucose Intolerance; Goals; Heart; High Throughput Assay; Humulin R; Institutes; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Interdisciplinary Research; Interdisciplinary Study; Intracellular Communication and Signaling; Investigators; Lipocytes; MODY; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Medical Research; Medicinal Chemistry; Metabolic; Mitochondria; MoAb R24; Molecular; Molecular Medicine; Monoclonal Antibody R24; Multidisciplinary Collaboration; Multidisciplinary Research; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Myocytes; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Pathway interactions; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Pharmacology; Physiology; Physiopathology; Plant Embryos; Prevalence; Prevention therapy; Process; R-24 Monoclonal Antibody; R24; Regulator Genes; Regulatory Pathway; Research Personnel; Research Support; Research, Medical; Researchers; Science of Chemistry; Scientist; Seeds; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Striated Muscle Tissue; Striated Muscles; Study, Interdisciplinary; System; System, LOINC Axis 4; T2D; T2DM; Testing; Tissues; Toxic effect; Toxicities; Transcriptional Regulatory Elements; Type 2 diabetes; Type II diabetes; Zygotes, Plant; adipose; adiposity; adult onset diabetes; base; biological signal transduction; biomarker; corpulence; corpulency; corpulentia; cytokine; diabetes; driving; high throughput screening; in vivo; insulin resistant; interdisciplinary approach; ketosis resistant diabetes; maturity onset diabetes; mitochondrial; nano science; nanoscience; new diagnostics; next generation diagnostics; novel; novel diagnostics; obese; obese people; obese person; obese population; pandemic; pandemic disease; pathophysiology; pathway; public health relevance; regulatory gene; response; seed; small molecule; therapeutic target; trans acting element; white adipose tissue; yellow adipose tissue",Probing the adipocyte-myocyte axis: An Interdisciplinary Approach,,84969,ZDK1,Special Emphasis Panel,,1,573000,
7761088,R25,GM,1,,02/01/2010,01/31/2011,PAR-06-548,1R25GM089568-01,,NIGMS:310603;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BROOKLYN,UNITED STATES,BIOLOGY,10,618059232,US,NY,112018423,LONG ISLAND UNIVERSITY BROOKLYN CAMPUS,"DEPASS, ANTHONY LYNDON;",8639561;,1R25GM089568,02/01/2010,01/31/2014,"Academic Training; Academic achievement; Address; Admission; Admission activity; Affect; African American; Afro American; Afroamerican; Area; Asia; Award; Baccalaureate Degree; Bachelor's Degree; Bears; Biliary or Urinary Stones; Biochemistry; Biologic Sciences; Biological Sciences; Biology; Black Populations; Black or African American; Calculi; Caribbean; Caribbean Sea Region; Caribbean region; Chemistry; Chemistry, Biological; Chemistry, Organic; Clinical Sciences; Cognitive Discrimination; Collaborations; Communities; Complement; Complement Proteins; Data; Development; Development and Research; Discipline; Discrimination; Discrimination (Psychology); EXTMR; Economically Deprived; Economically Deprived Population; Education; Educational Achievement; Educational Status; Educational aspects; Educational process of instructing; Educational workshop; Effectiveness; Enrollment; Ensure; Environment; Ethics; Ethnic and Racial Minorities; Evaluation; Extramural; Extramural Activities; Faculty; Female; Foundations; Funding; Gatekeeping; Generalized Growth; Goals; Growth; Health Occupations; Health Professions; Hispanic Populations; Hispanics; Hispanics or Latinos; History; Home; Home environment; Hour; Immigrant; Individual; Institution; Institutional Practice; Intervention; Intervention Strategies; Intramural Research; Investigators; Jewish; Jewish, follower of religion; Knowledge; Laboratories; Laboratory Research; Latino Population; Leadership; Learning; Life Sciences; Literature; Long Island; Master's Degree; Measurable; Medicine; Mentors; Mentorship; Methods and Techniques; Methods, Other; Minority; Minority Groups; Modeling; Monitor; New York; New York City; Newsletter; Organic Chemistry; Outcome; Performance; Pharmacy Schools; Population; Posters; Posters [Publication Type]; Preparation; Principal Investigator; Probability; Production; Program Development; Programs (PT); Programs [Publication Type]; Publishing; Qualifying; R & D; R&D; Reading; Recording of previous events; Recruitment Activity; Regimen; Relative; Relative (related person); Reporting; Research; Research Personnel; Research Resources; Research Support; Research Technics; Research Training; Research, Laboratory; Researchers; Resources; Running; Schools; Schools, Medical; Schools, Pharmacy; Science; Science of Chemistry; Science of Medicine; Scientist; Self Assessment; Self Assessment (Psychology); Self Efficacy; Series; Services; Social Support System; Soviet Union; Spanish Origin; Stone; Students; Support System; Survey Instrument; Surveys; System; System, LOINC Axis 4; Teaching; Techniques; Techniques, Research; Technology; Testing; Thinking; Thinking, function; Time; Tissue Growth; Training; Training Activity; Training Programs; Training, Academic; Translating; Translatings; USSR; Underrepresented Minority; Union of Soviet Socialist Republics; Universities; Ursidae; Ursidae Family; West Indies Region; Work; Workshop; Writing; base; black American; career; college; conference; demographics; design; designing; educational level; enroll; experience; experiment; experimental research; experimental study; follower of religion Jewish; gatekeeper; health science profession; hispanic community; innovate; innovation; innovative; interest; interventional strategy; language translation; medical schools; meetings; member; novel; ontogeny; peer; posters; programs; public health relevance; recruit; research and development; research study; responsible research conduct; sex; skills; stem; success; symposium; training achievement; training level; training status; under-represented minority; underserved minority; web site",Long Island University- Brooklyn MBRS- RISE Program, Narrative The activities described in this proposal will effectively increase the diversity in the scientific workforce through a very intensive training regiment that is designed to better prepare students from underrepresented minorities in the sciences for doctoral level training in the biomedical sciences.,89568,MPRC,Minority Programs Review Committee,,1,310603,
7761074,R25,GM,1,,02/01/2010,01/31/2011,PAR-07-411,1R25GM089573-01,,NIGMS:160440;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,ENGINEERING (ALL TYPES),07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"CHUDLER, ERIC H;",1907452;,1R25GM089573,02/01/2010,01/31/2015,"Advertisements; Advocate; African American; Afro American; Afroamerican; Baccalaureate Degree; Bachelor's Degree; Behavioral Sciences; Biocompatible Materials; Biomaterials; Biomedical Engineering; Biomedical Research; Biotechnology; Black Populations; Black or African American; Communicable Diseases; Communication; Communities; Counseling; Counselor; Development; E-Mail; Educational workshop; Electronic Mail; Email; Engineering; Engineerings; Enrollment; Environmental Health; Environmental Health Science; Essays (PT); Essays [Publication Type]; Ethical Issues; Faculty; Food; Grant; Health; Hispanic Americans; Hour; Human Resources; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Institution; Issues, Ethical; Journals; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Legal; Letters; Magazine; Manpower; Mentors; Methods; Molecular Nano technology; Molecular Nanotechnology; NIH; National Institutes of Health; National Institutes of Health (U.S.); Native Americans; Newspapers; Oral; Pacific Islands; Participant; Population Group; Posters; Posters [Publication Type]; Process; Production; Professional counselor; Programs (PT); Programs [Publication Type]; Public Speaking; Recommendation; Research; Science; Scientist; Source; Spanish Americans; Speaking, Public; Students; Technology; Transcript; Underrepresented Minority; United States National Institutes of Health; Universities; Washington; Work; Workshop; World Health; Writing; bioengineering; bioengineering/biomedical engineering; black American; career; cohort; college; college student; conference; enroll; essays; experience; high school; instructor; interest; lectures; personnel; posters; programs; public health relevance; skills; stem; symposium; technical writing; under-represented minority; underserved minority; university student",Building Bridges to Bioengineering," 7. Project Narrative Building Bioengineering Bridges (B3) will work with underrepresented minority students from Seattle Community College as they transition to baccalaureate degree programs at the University of Washington (UW) and other four-year universities. The B3 program will focus on how bioengineering and biotechnology can be used to solve global health problems. The B3 program will provide both academic opportunities and mentored research experiences for students and will include workshops and seminars to provide students will experience giving scientific presentations. The program will provide students with the background and experiences necessary to successfully transition from their community college to four-year universities. Through this effort, the partnering institutions will provide a source of outstanding URM students interested biomedical research to a variety of departments within the UW and other universities.",89573,ZGM1,Special Emphasis Panel,,1,160440,
7761930,R25,GM,1,,02/01/2010,01/31/2011,PAR-07-410,1R25GM089637-01,,NIGMS:298882;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,NONE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"CHADIHA, LETHA A;",2216044;,1R25GM089637,02/01/2010,01/31/2013,"AHCPR; AHRQ; Academia; Acceptability of Healthcare; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Address; Admission; Admission activity; Advocacy; Affect; African American; Afro American; Afroamerican; Agency for Health Care Policy and Research; Agency for Healthcare Research and Quality; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; American; Asians; Attention; Availability of Health Services; Behavioral; Behavioral Sciences; Biological; Black Populations; Black or African American; California; Care, Health; Caring; Chicago; Chronic Disease; Chronic Illness; Communities; Coupled; Data; Decision Making; Discipline of Nursing; Doctor of Philosophy; Education; Educational aspects; Employment; Enrollment; Ensure; Ethnic and Racial Minorities; Ethnic group; FLR; Faculty; Failure (biologic function); Force of Gravity; Future; General Population; General Public; Goals; Government Programs; Grant; Gravities; Health; Health Care Acceptability; Health Care Professional; Health Care Sector; Health Care Utilization; Health Professional; Health Services; Health Services Accessibility; Health profession; Healthcare; Healthcare Acceptabilities; Healthcare Sector; Healthcare professional; Healthcare worker; Heterogeneity, Population; Hispanic Populations; Hispanics; Hispanics or Latinos; Human Resources; Improve Access; Incentives; Individual; Institute of Medicine; Institute of Medicine (U.S.); Institution; Investigators; Knowledge; Language; Latino; Latino Population; Los Angeles; Manpower; Master's Degree; Mental Health; Mental Hygiene; Mentors; Michigan; Minority; Minority Groups; Mission; Monitor; NAS/IOM; NIGMS; NIH; National Institute of General Medical Sciences; National Institutes of Health; National Institutes of Health (U.S.); Native Alaskan; Native Hawaiian or Other Pacific Islander; News; News (PT); News [Publication Type]; Nurses; Nursing; Nursing Field; Nursing Profession; Nursing Students; Outcome; Pacific Island Americans; Pacific Islander; Pacific Islander American; Participant; Patient Care; Patient Care Delivery; Patients; Pennsylvania; Personnel, Nursing; Persons; Ph.D.; PhD; Physiologic; Physiological; Policies; Population; Population Heterogeneity; Preparation; Programs (PT); Programs [Publication Type]; Psychological Health; Public Health; Pupil Nurses; Quality of Health Care; Quality of Healthcare; Race; Racial Group; Recruitment Activity; Reporting; Research; Research Personnel; Researchers; Review Literature; Role; San Francisco; School Health Nursing; School Nursing; Schools; Scientist; Services; Social Environment; Social Sciences; Social Service; Social Work; Social Workers; Social work (field); Spanish Origin; Stocks, Racial; Student Loan; Students; Students, Nursing; Target Populations; Time; Training; Trust; Underrepresented Minority; United States Agency for Health Care Policy and Research; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Washington; Workers, Social; access to services; access to treatment; availability of services; base; black American; care giving; career; career development; caregiving; chronic disease/disorder; chronic disorder; cohort; college; design; designing; diverse populations; enroll; ethnic minority; ethnic minority population; evidence base; failure; graduate student; health care availability; health care quality; health care service; health care service access; health care service availability; health care service utilization; health disparities; health disparity; health services availability; health services utilization; healthcare access availability; healthcare service access; healthcare service availability; healthcare service utilization; healthcare utilization; heterogeneous population; hispanic community; improved; incentive; inducement; insight; interest; member; minority health; news; oriental; personnel; programs; public health medicine (field); public health relevance; racial and ethnic; racial and ethnic disparities; racial/ethnic; recruit; residence; response; role model; skills; skills training; social; social climate; social context; social role; socioenvironment; success; treatment utilization; under-represented minority; underserved minority",UM Social Work/Nursing Bridges to the Doctoral Program, PROJECT NARRATIVE Health disparities remain a serious national public health concern. The gravity of the problem of persistent health disparities is compounded by the low number of trained behavioral scientists from underrepresented minority populations that are disproportionately affected by health disparities and hold Ph.D. degrees. The overall goal of the University of Michigan Social Work/Nursing Bridges to the Doctorate Program is to increase the number of trained behavioral scientists holding Ph.D. degrees and conducting health disparities research.,89637,MPRC,Minority Programs Review Committee,,1,298882,
7690135,R25,RR,1,,01/01/2010,12/31/2010,PAR-06-549,1R25RR026014-01,,NCRR:258780;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,COLUMBIA,UNITED STATES,,06,966244915,US,SC,292013067,EDVENTURE CHILDREN'S MUSEUM,"BONK, SUSAN EMILY;",9609547;,1R25RR026014,01/01/2010,12/31/2014,"0-11 years old; 21+ years old; Adult; Affect; Age; Anxiety; Area; Behavior; Biomedical Research; Career Choice; Cause of Death; Child; Child Youth; Children (0-21); Chronic Disease; Chronic Illness; Collaborations; Communities; Depressed mood; Disadvantaged; Disease; Disorder; Educational process of instructing; Elements; Engineering; Engineerings; Environment; Exhibits; Exposure to; Familiarity; Family; Feeling; Flooding; Floods; Funding; Future; General Population; General Public; Genotype; Goals; Hand; Health; Health Sciences; Human Figure; Human body; Human, Adult; Human, Child; Investigators; Laboratories; Lead; Life; Life Expectancy; Life Style; Lifestyle; Low Income Population; Medical; Mentors; Microscopic; Minority; Museums; Names; Nanoscale Science; Nanotechnology; Nature; Participant; Pathway interactions; Pb element; Population; Position; Positioning Attribute; Process; Program Development; Programs (PT); Programs [Publication Type]; Public Health; Research; Research Personnel; Researchers; Rural; Schools; Science; South Carolina; Stem Cell Research; Students; Teaching; Technology; Teen; Teenagers; Teens; Time; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Underrepresented Minority; Underserved Population; Universities; Youth; Youth 10-21; adult human (21+); base; career; children; chronic disease/disorder; chronic disorder; depressed; design; designing; disease/disorder; empowered; evidence base; experience; experiment; experimental research; experimental study; feelings; health disparities; health disparity; heavy metal Pb; heavy metal lead; interest; language translation; nano scale Science; nano science; nano tech; nano technology; nanoscience; nanotech; pathway; population health; programs; public health medicine (field); public health relevance; research study; sadness; skills; teacher; teen years; tool; translation research enterprise; under served population; under-represented minority; underserved minority; underserved people; youngster","Unlocking the Mysteries of Chronic Disease:  Bioinvestigations for Family, School"," Narrative: ""Unlocking the Mysteries of Chronic Disease: BioInvestigations for Family, School and Youth Audiences"" is specifically relevant to public health as it provides information to museum visitors and program participants about the chronic diseases and health disparities in the state of South Carolina and the current research around these topics. Additionally, participants gain an understanding of the personal choices they can make to positively influence their health and acquire tools to make evidence-based decisions about critical health issues.",26014,ZRR1,Special Emphasis Panel,,1,258780,
7788469,R34,MH,1,,02/01/2010,11/30/2010,PAR-06-248,1R34MH083832-01A2,,NIMH:225000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,COLLEGE PARK,UNITED STATES,SOCIAL SCIENCES,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"CHRONIS-TUSCANO, ANDREA M (contact);RUBIN, KENNETH H;",2104188;7752357 (contact);,1R34MH083832,12/01/2009,11/30/2012,"0-11 years old; 1-5 years old; 12-20 years old; 21+ years old; Active Follow-up; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; After Care; After-Treatment; Aftercare; Age; Agoraphobia; Anxiety; Anxiety Disorders; Anxiety, Separation; Area; Au element; Behavior; Behavioral; Behavioral inhibition; Categories; Characteristics; Characteristics, Social; Child; Child Behavior; Child Youth; Child, Preschool; Childhood; Children (0-21); Clinical; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Coercion; Control Groups; Data; Depression; Depressive disorder; Development; Developmental Process; Diagnosis; Diagnostic; Dimensions; Disease; Disorder; Early identification; Early treatment; Effectiveness; Emotional; Ensure; Event; Evidence based intervention; Exclusion; Family; Fear; Feedback; Feeling; Focus Groups; Foxes; Friendships; Fright; Funding; Generalized Anxiety Disorder; Goals; Gold; Hand; Hostility; Human Resources; Human, Adult; Human, Child; Impairment; Individual; Infant; Intervention; Intervention Strategies; Interview; Investigators; Life; Literature; Loneliness; Manpower; Manuals; Measures; Mental Depression; Methods; Methods and Techniques; Methods, Other; Minority; Modeling; Mothers; Mutism, Elective; Mutism, Selective; Mutism, Voluntary; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neurosis, Depressive; Nursery Schools; Outcome; Outcome Measure; Panic Disorder; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting behavior; Parents; Participant; Pathway interactions; Patient Self-Report; Peer Group; Phase; Play; Population; Preschool Child; Prevalence; Prevention; Prevention Protocols; Prevention program; Preventive; Preventive Intervention; Problem Solving; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychopathology; Public Health; Publishing; Questionnaires; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk; Risk Factors; Sampling; Schools; Schools, Nursery; Self-Report; Separation Anxiety; Services; Shyness; Social Behavior; Social Characteristics; Social Development; Social Environment; Social Interaction; Social Phobia; Specific Phobia; Staging; Structure; Suggestion; Survey Instrument; Surveys; Symptoms; Targeted Research; Techniques; Testing; Time; Toddler; Training; Training Programs; United States National Institute of Mental Health; Victimization; Voluntary Mutism; Waiting Lists; Withdrawal; Work; abnormal psychology; adolescence (12-20); adult human (21+); base; childhood anxiety; children; clinical investigation; design; designing; disease/disorder; domain mapping; efficacy testing; elementary school; emotional adaptation; emotional adjustment; emotional style; evidence base; experience; feelings; follow-up; improved; in vivo; indexing; infancy; infantile; innovate; innovation; innovative; interest; interpersonal competence; interpersonal competency; intervention development; intervention program; interventional strategy; juvenile; juvenile human; meetings; model development; neglect; novel; panic anxiety syndrome; parent child interaction; parent influence; parent offspring interaction; parental influence; pathway; pediatric; peer; personnel; preschool child (1-5); preventional intervention strategy; primary outcome; programs; psychologic; psychological; psychological outcomes; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; recruit; response; satisfaction; secondary outcome; self esteem; skills; skills training; social; social climate; social competence; social competency; social context; social skills; sociobehavior; sociobehavioral; socioenvironment; teacher; teenage; theories; therapy development; treatment development; youngster",A Multi-Method Early Intervention Program for Inhibited and Anxious Preschoolers," Project Narrative Behavioral inhibition (BI), along with its associated characteristics of social reticence and withdrawal, is one of the most stable individual characteristics reported in childhood. Socially inhibited, wary and withdrawn preschool children are at risk for subsequent diagnosable anxiety and depressive disorders during adolescence and adulthood. Given the serious developmental outcomes associated with adolescent anxiety, very early identification and prevention of early social inhibition represents a major public health agenda.",83832,ITVC,Interventions Committee for Disorders Involving Children and Their Families,A2,1,225000,
7774062,R36,HS,1,,02/01/2010,04/30/2011,PAR-06-118,1R36HS018233-01,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,ATLANTA,UNITED STATES,OTHER HEALTH PROFESSIONS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"SCHIPPITS, KIM MARIE;",9703352;,1R36HS018233,02/01/2010,04/30/2011,,The Magnet Journey: Understanding the Role of Unit Culture in EBP Adoption," Patients admitted to the hospital are entitled to safe, effective, quality care that is based on an evidence-based decision-making process that incorporates the best evidence, patient preferences, and clinical expertise. Hospitals have yet to consistently implement EBP and therefore care is not always safe, effective, or of good quality. This study will begin to identify how the magnet culture affects the emergence and maintenance of EBP by identifying theoretically based cultural and individual interventions that will optimize EBP implementation that will improve the quality, safety, and effectiveness of care provided.",18233,HCRT,HSR Health Care Research Training SS,,1,37800,
7873947,R36,HS,1,,02/01/2010,01/31/2011,PAR-06-118,1R36HS018809-01,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,MADISON,UNITED STATES,ENGINEERING (ALL TYPES),02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"VALDEZ, RUPA SHETH;",10000602;,1R36HS018809,02/01/2010,01/31/2011,,Creating a foundation for the design of culturally-informed health IT," The goal of this program of research is to reduce healthcare disparities by creating systematic ways to incorporate cultural patterns of daily living as design guidance for consumer health IT. It addresses goals of national initiatives such as Health People 2010 to eliminate disparities in health care attributable to cultural differences. The work blends methods from systems engineering and anthropology to better address the needs, values, preferences and behaviors of persons with a wide range of cultural identities.",18809,HCRT,HSR Health Care Research Training SS,,1,33914,
7803769,R41,ES,1,,02/01/2010,01/31/2011,PA-09-007,1R41ES018022-01,,NIEHS:150000;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,TROY,UNITED STATES,,21,173649075,US,NY,121803511,"SOLIDUS BIOSCIENCES, INC.","LEE, MOO-YEAL ;",7786567;,1R41ES018022,02/01/2010,01/31/2011,"2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; APAP; Acetamide, N-(4-hydroxyphenyl)-; Acetamidophenol; Acetaminophen; Acetominophen; Address; Adenoviridae; Adenoviruses; Affect; Alginates; Analysis, Data; Animals; Assay; Bioassay; Biologic Assays; Biological Assay; CP12; CP33; CP34; CTX; CYCLO-cell; CYP1A2; CYP1A2 gene; CYP3; CYP3A; CYP3A13; CYP3A3; CYP3A4; CYP3A4 gene; CYPIIIA4; Carloxan; Catalysis; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; Clinical Trials; Clinical Trials, Unspecified; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytophosphan; Cytophosphane; Cytoxan; Data; Data Analyses; Development; Drug or Chemical; Drugs; Encapsulated; Endoxan; Endoxana; Enduxan; Environmental Pollutants; Enzymes; Epithelial Cells; Evaluation; Exposure to; FP593; Fluorogenic Substrate; Fosfaseron; GFP; Generations; Genes; Genes, Reporter; Genoxal; Genuxal; Glass; Green Fluorescent Proteins; HLP; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hepatotoxic effect; Hepatotoxicity; Human; Human Figure; Human body; Human, General; Hydroxyacetanilide; In Vitro; Individual; Institutes; Intermediary Metabolism; Investigators; Investments; Isoforms; Lead; Ledoxina; Libraries; Liver; Liver Cells; Liver Toxicity; Lung; METBL; Man (Taxonomy); Man, Modern; Measurement; Medication; Metabolic; Metabolic Processes; Metabolism; Methods; Mitoxan; N-(4-Hydroxyphenyl)acetanilide; N-Acetyl-p-aminophenol; NF-25; Neosar; Organ; P3-450; P450; P450(PA); P450-PCN1; P450C3; P450PCN1; Paracetamol; Parents; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Population; Predisposition; Process; Procytox; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protocol; Protocols documentation; Protocols, Treatment; Public Health; RGM; Recombinants; Regimen; Reporter Genes; Research; Research Personnel; Researchers; Respiratory System, Lung; STTR; SUBGP; Safety; Screening procedure; Sendoxan; Simulate; Slide; Small Business Technology Transfer Research; Speed; Speed (motion); Staging; Subgroup; Substrate, Fluorogenic; Susceptibility; Syklofosfamid; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Time; Toxic effect; Toxic effect on liver cells; Toxicities; Toxicology; Transfection; Treatment Protocols; Treatment Regimen; Treatment Schedule; Viral; Xenobiotic Metabolism; Xenobiotics; Zytoxan; base; body system, hepatic; cDNA Library; cell type; clinical investigation; cultured cell line; design; designing; drFP583; drug candidate; drug development; drug discovery; drug/agent; ds red protein; dsFP593; environmental chemical; flexibility; heavy metal Pb; heavy metal lead; hepatoxicity; high risk; high throughput analysis; in vivo; monolayer; organ system, hepatic; p-Acetamidophenol; p-Hydroxyacetanilide; programs; public health medicine (field); public health relevance; pulmonary; red fluorescent protein; response; screening; screenings; tool; toxicant","TeamChip for High-throughput, Predictive Human Metabolism and Toxicology"," Project Narrative  The drug discovery process is an investment-intensive, high-risk endeavor that results in low yields of effective and safe drugs; a problem that is confounded by the significant lack of information that exists in predicting the metabolic fate of drug candidates, in general, and in predicting the reactivity of drug candidates in the human body. The proposed Phase I STTR project for the development of Solidus Bioscience's TeamChip technology has significant relevance to public health by providing pharmaceutical researchers with the information needed to predict the in vivo metabolism of drug candidates, and thus help to decide which compounds are brought forward for lead optimization and the ultimate development of better and safer drugs. Furthermore, this research is relevant to the prioritization of industrial and environmental chemicals in terms of their safety and use. 1",18022,ZRG1,Special Emphasis Panel,,1,150000,
7803512,R41,GM,1,,02/01/2010,01/31/2011,PA-09-114,1R41GM090585-01,,NIGMS:200000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ITHACA,UNITED STATES,,22,884942012,US,NY,148531279,"VYBION,  INC.","DELISA, MATTHEW P;",7980421;,1R41GM090585,02/01/2010,01/31/2011,"ATGN; Accounting; Affinity; Affinotoxins; Antibodies; Antibody Affinity; Antibody Fragments; Antibody Therapy; Antigen Targeting; Antigens; Arginine; Arginine, L-Isomer; Binding; Binding (Molecular Function); Biological; Biosynthetic Proteins; Biotechnology; Cancers; Cell surface; Cells; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collection; Complex; Culture Media; Cytoplasm; Cytotoxin-Antibody Conjugates; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Diagnostics Research; Disease; Disorder; Drugs; Engineering; Engineerings; Ensure; Environment; Enzymes; Esteroproteases; Evolution; Future; Genes; Goals; Health; Human; Human, General; Immobilization; Immunization; Immunoglobulin Fragments; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Immunotoxins; Inflammatory; L-Arginine; Lactamase; Libraries; Light; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Marketing; Medication; Membrane; Methods; Methods and Techniques; Methods, Other; Moab, Clinical Treatment; Molecular; Molecular Interaction; Monoclonal Antibodies; Monoclonal Antibody-Toxin Conjugates; Nature; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Pathway interactions; Peptidases; Peptide Hydrolases; Peptides; Periplasmic Space; Phage Display; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Production; Property; Property, LOINC Axis 2; Proteases; Protein Export; Protein Export Pathway; Proteinases; Proteins; Proteolytic Enzymes; Quality Control; Reagent; Recombinant Antibody; Recombinant Proteins; Relative; Relative (related person); Reporter; Research; Resistance; Screening procedure; Selection (Genetics); Sensitization, Immunologic; Sensitization, Immunological; Series; Solid; Specificity; Staging; Structure; Surface; System; System, LOINC Axis 4; TAT; Techniques; Technology; Toxin-Antibody Conjugates; Toxin-Antibody Hybrids; Trans-Activation of Transcription Protein; Trans-Activator of Transcription of HIV; Transactivating Regulatory Protein; Twin Multiple Birth; Twins; Viral Diseases; Virus Diseases; Yeasts; antigen antibody affinity; antigen antibody binding; antigen binding; base; clinical investigation; combinatorial; commercial application; cost; design; designing; directed evolution; disease/disorder; drug development; drug/agent; experiment; experimental research; experimental study; gene product; growth media; human disease; immobilization of body part; immunogen; innovate; innovation; innovative; interest; malignancy; membrane structure; neoplasm/cancer; neurodegenerative illness; new technology; new therapeutics; next generation therapeutics; novel; novel therapeutics; orthopedic freezing; pathway; periplasm; periplasmic; polypeptide; pre-clinical; preclinical; protein expression; protein folding; public health relevance; research study; resistant; screening; screenings; secretory protein; success; tat Protein; therapeutic protein; therapeutic target; tool; viral infection; virus infection",Rapid isolation of high-affinity human antibodies from large synthetic libraries," Project Narrative By 2008, engineered antibody fragments are predicted to account for >30% of all revenues in the biotechnology market and will be used to treat a wide array of human diseases including bacterial and viral infections, cancer, inflammatory diseases and neurodegenerative disorders. Since antibody therapies are an increasingly large fraction of the drugs in development, with ever escalating increases in the cost of drug development, any improvements to the production or discovery of efficacious antibody fragments will have a significant impact on human health. Thus, this proposal seeks to develop a novel bacterial selection strategy for rapid, low-cost isolation of potent human antibodies against virtually any target antigen of interest.",90585,ZRG1,Special Emphasis Panel,,1,200000,
7801467,R41,NS,1,,02/01/2010,01/31/2011,PA-09-081,1R41NS064708-01A2,,NINDS:176926;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,TAMPA,UNITED STATES,,11,039606491,US,FL,33612,"SANERON CCEL THERAPEUTICS, INC.","CHEN, JIELI ;",7646962;,1R41NS064708,02/01/2010,01/31/2011,"21+ years old; Adjuvant; Adult; Apoplexy; Blood Cell Count; Blood Cell Number; Blood Cells; Blood, Cord; Body Tissues; Bone Marrow Stem Cell; Brain; Cell Locomotion; Cell Migration; Cell Movement; Cell Therapy; Cells; Cellular Migration; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Combined Modality Therapy; Common Rat Strains; Data; Dose; Encephalon; Encephalons; Figs; Figs - dietary; GVHD; Graft-Versus-Host Disease; Graft-vs-Host Disease; Homologous Wasting Disease; Human; Human, Adult; Human, General; Infarction; Intention; Mammals, Rats; Man (Taxonomy); Man, Modern; Middle Cerebral Artery Occlusion; Modality; Modeling; Mono-S; MonoS; Morbidity; Morbidity - disease rate; Motility; Motility, Cellular; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Nervous System Physiology; Nervous System, Brain; Neural Growth; Neurologic; Neurologic function; Neurological; Neurological function; Neuronal Growth; Occlusion, Middle Cerebral Artery; Outcome; Peripheral Blood Cell; Pharmacological Treatment; Population; Rat; Rattus; Recovery; Regulation; Risk; Runt Disease; Simvastatin; Stroke; Synvinolin; Testing; Therapeutic; Therapeutic Effect; Therapy, Cell; Tissues; Translating; Translatings; Treatment Efficacy; Umbilical Cord Blood; Vascular Accident, Brain; adult human (21+); adult youth; angiogenesis; base; brain attack; brain tissue; cell motility; cell-based therapy; cerebral vascular accident; clinical relevance; clinically relevant; combination therapy; combined modality treatment; combined treatment; design; designing; disability; fetal cord blood; functional outcomes; improved; infarct; language translation; migration; multimodality therapy; nervous system function; neurogenesis; new therapeutic target; post stroke; poststroke; prototype; public health relevance; response; stroke; stroke recovery; stroke therapy; therapeutic efficacy; therapeutically effective; young adult",Neuroprotective therapy of stroke with HUCNC and simvastatin," Project Narrative Stroke is the third leading cause of morbidity and long-term disability. Treatment of stroke has taken essentially two approaches, cellular and pharmacological therapy. We propose to combine cell and pharmacological treatment, to enhance recovery of neurological function post stroke. Our preliminary data show that the human umbilical cord blood cells (HUCBCs) treatment of stroke improves functional outcome. Combination of sub- therapeutic doses of simvastatin with HUCBCs increases exogenously administered cell migration into the ischemic brain and additively improves the therapeutic outcome after stroke. Thus, we propose that HUCBC cell-based therapy can be enhanced by making the tissue more receptive to the administered cells by creating a microenvironment within the ischemic cerebral tissue that facilitates cell-based induction of brain plasticity. A clinically relevant embolic middle cerebral artery occlusion (MCAo) rat model will be used in this study, which will provide new and important data regarding novel therapeutic targets for stroke recovery.",64708,ZRG1,Special Emphasis Panel,A2,1,176926,
7801739,R41,NS,1,,01/18/2010,12/31/2010,PA-09-081,1R41NS065559-01A1,,NINDS:199281;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MELVILLE,UNITED STATES,,02,806706144,US,NY,117473821,"POPULATION DIAGNOSTICS, INC.","HATCHWELL, ELI ;",7038729;,1R41NS065559,01/18/2010,12/31/2010,"Affect; Aged 65 and Over; Allele Frequency; Assay; Back; Bioassay; Biologic Assays; Biological; Biological Assay; Biology; Bradykinesia; Causality; Communities; Comparative Genome Hybridization; Complex; Critiques; Cross-Product Ratio; DNA; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Diagnosis; Diagnostic tests; Disease; Disorder; Dopaminergic Cell; Dorsum; Dysfunction; Elderly; Elderly, over 65; Etiology; Exons; Frequencies (time pattern); Frequency; Functional disorder; Future; GWAS; Gel; Gene Frequency; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Heterogeneity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genome Scan; Genomics; Goals; Hereditary Disease; Hybridization Array; Idiopathic Parkinson Disease; Incidence; Individual; Inherited Predisposition; Inherited Susceptibility; Intervention; Intervention Strategies; Knowledge; Lewy Body Parkinson Disease; Light; Method LOINC Axis 6; Methodology; Methods; Molecular Disease; Muscle Rigidity; Odds Ratio; Oligo; Oligonucleotides; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathology; Pathway interactions; Patients; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Photoradiation; Physiopathology; Polymorphism, Single Base; Primary Parkinsonism; Relative Odds; Research; Resolution; Rest Tremor; Rigidity; Rigidity, Muscular; Risk; Risk Ratio; Role; SNP; SNPs; Sampling; Single Nucleotide Polymorphism; Stratification; Substantia Nigra; Substantia nigra structure; Therapeutic Intervention; Uncertainty; Variant; Variation; advanced age; allelic frequency; base; biomarker; clinical data repository; clinical data warehouse; cohort; comparative genomic hybridization; data repository; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; doubt; elders; genetic disorder; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; geriatric; hereditary disorder; improved; insight; intervention therapy; interventional strategy; late life; later life; next generation; novel; older adult; older person; pathophysiology; pathway; public health relevance; relational database; senior citizen; social role; theories; therapeutic development; whole genome association studies; whole genome association study",Identification and Characterization of Causative Genetic Biomarkers for Parkinson," There is no doubt that the only rational approach to future therapeutic interventions in common disorders, such as Parkinson's Disease (PD), is one that will be based on a more precise knowledge of the underlying biological causes of such disorders. The successful application of genome wide copy number analysis for biomarker development in PD will facilitate improved diagnostic testing and risk stratification as well as yielding insight into the underlying pathogenesis of PD, paving the way for research into specific interventions, whether pharmaceutical or otherwise.",65559,ZRG1,Special Emphasis Panel,A1,1,199281,
7803709,R41,NS,1,,02/01/2010,01/31/2011,PA-07-390,1R41NS067874-01,,NINDS:221890;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,,15,155819035,US,MI,48108,NEURONEXUS TECHNOLOGIES,"KIPKE, DARYL R;SEYMOUR, JOHN P (contact);",6578458;8092230 (contact);,1R41NS067874,02/01/2010,01/31/2011,"Acute; Address; Adhesions; Amputees; Animals; Biomimetics; Body Tissues; Brain; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Cessation of life; Chronic; Clinical; Data Set; Dataset; Death; Defect; Devices; Electrical Impedance; Electrodes; Electrodes, Miniaturized; Electron Microscopy; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Engineering; Engineerings; Epilepsy; Epileptic Seizures; Epileptics; Evaluation; Figs; Figs - dietary; Foreign Bodies; Goals; Histology; Hortega cell; Impedance; Implant; Intracellular Communication and Signaling; Laboratories; Lead; Learning; Length of Life; Longevity; Measurement; Mechanical Stress; Mechanics; Memory; Metric; Michigan; Microelectrodes; Microfabrication; Microglia; Mimetics, Biological; Modification; Mother Cells; Myelopathy, Traumatic; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology / Electrophysiology; Neurosciences; Noise; Optics; Outcome Measure; Patients; Pb element; Performance; Phase; Preparation; Prevention; Process; Progenitor Cells; Proxy; Relative; Relative (related person); Research; Resolution; Science of neurophysiology; Seizure Disorder; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spinal Column; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Spine; Stem cells; Stress Tests; Stress, Mechanical; Structure; Surface; Technology; Testing; Thick; Thickness; Time; Tissues; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Universities; Validation; Vertebral column; Work; attenuation; backbone; biocompatibility; biological signal transduction; biomaterial compatibility; brain machine interface; cell body (neuron); clinical applicability; clinical application; deep brain stimulator; density; design; designing; electric impedance; epilepsia; epileptiform; epileptogenic; experience; experiment; experimental research; experimental study; gitter cell; heavy metal Pb; heavy metal lead; improved; in vivo; innovate; innovation; innovative; language translation; life span; lifespan; mesoglia; metrology; microglial cell; microgliocyte; motor control; nervous system disorder; neural; neural cell body; neurological disease; neuronal; neuronal cell body; neurophysiology; next generation; novel; parylene; perivascular glial cell; poly(chloro-p-xylylene); prevent; preventing; prototype; public health relevance; relating to nervous system; research study; response; sensory system; soma; systems research; technology development; tool; translation research enterprise; usability",Long-term Sensing in the Brain Using Sub-cellular Edge Electrode Arrays," Project Narrative The primary objective of the proposed work is to develop and validate a microelectrode technology that has shown great promise in improving biocompatibility. This work will microfabricate a novel biomimetic design, the ""sub-cellular edge electrode"" array, and provide subsequent long-term validation in animal studies. Animal studies are expected to show improved electrophysiological recording quality, stability, and longevity. Such microelectrode technology will enable neuroscientists and clinicians to achieve long-term sensing in the brain, which would greatly improve our understanding of healthy brain function and offer new opportunities for those suffering from neurological disorders such as spinal cord injury, epilepsy, or ALS.",67874,ZRG1,Special Emphasis Panel,,1,221890,
7908443,R43,AI,1,,02/01/2010,01/31/2011,PA-09-095,1R43AI081404-01A2,,NIAID:200000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Aurora,UNITED STATES,,01,160156543,US,CO,80045,"ISOGENIS, INC.","BRENNAN, MILES ;",1869273;,1R43AI081404,02/01/2010,01/31/2012,"2S-isocapryloyl-3S-hydroxymethyl-gamma-butyrolactone; A-factor; A-factor (Streptomyces); ATGN; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Animal Model; Animal Models and Related Studies; Animals; Antigens; Architecture; Back; Biology; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; Capsid; Cells; Clinical; Complex; Defect; Development; Disease; Disorder; Dorsum; Engineering / Architecture; Enzymes; F8 protein, human; F8B protein, human; FVIII protein, human; Factor VIII Deficiency; Gene Expression; Gene Therapy Vectors; Gene Transduction Agent; Gene Transduction Vectors; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genes, Viral; Genetic Intervention; Genome, Human; Goals; Helper Viruses; Hemophilia; Hemophilia A; Hemophilia As; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human Genome; Human, General; Immune; Immune response; Immunity; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Interphase Cell; Intervention, Genetic; L-factor (Streptomyces); LYT3; Lead; Learning; Length; Liver Cells; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Molecular Biology, Gene Therapy; Murine; Mus; Natural immunosuppression; Non-dividing Cell; Oncogenic; Ornithine Carbamoyltransferase Deficiency Disease; Ornithine Transcarbamylase Deficiency Disease; Ornithine carbamoyltransferase deficiency; Patients; Pb element; Preparation; Principal Investigator; Production; Proteins; Reagent; Recombinants; Research; Resting Cell; Retroviridae; Retroviruses; Serotyping; Surface; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Testing; Therapeutic; Therapeutic Effect; Therapy, DNA; Thymus-Dependent Lymphocytes; Time; Tissues; Transgenes; Treatment Efficacy; Viral; Viral Genes; Viral Vector; Virus; Virus Replication; Virus-Retrovirus; Viruses, General; adeno vector; adenovector; base; cell type; coagulation factor VIII, procoagulant component (hemophilia A) protein, human; coat (nonenveloped virus); design; designing; disease/disorder; effective therapy; factor VIII, human; gene product; gene repair; gene therapy; gene transfer vector; genetic therapy; genetically engineered virus; heavy metal Pb; heavy metal lead; host response; human F8 protein; hyperammonemia due to ornithine transcarbamylase deficiency; hyperammonemic syndrome; immunogen; immunogenic; immunogenicity; immunoresponse; immunosuppression; in vivo; innovate; innovation; innovative; model organism; mouse model; novel; ornithine carbomoyltransferase (OCT) deficiency; ornithine transcarbamylase (OTC) deficiency (OTCD); ornithine transcarbamylase deficiency; particle; pre-clinical; preclinical; public health relevance; repair; repaired; success; therapeutic efficacy; therapeutically effective; thymus derived lymphocyte; vector; virus multiplication",Activity of Fully Deleted Helper-Virus Independent Adenoviral Gene Therapy Vector," Principal Investigator: Brennan, Miles B. The goal of gene therapy is the cure of the disease by the introduction or repair of the defective gene. In the case of hemophilia A and OTCD, the 'missing' enzyme will be directly delivered to the resident hepatocytes. Gene therapy vectors will have to lead to sustained gene expression in their target tissue to provide a permanent cure. Immune responses directed against vector proteins generally negate any therapeutic effect. Therefore, strategies are being sought that allowed the production of effective gene therapy vectors that did no longer contain vector-derived, i.e. viral, genes. In the case of adenoviral vectors such fully deleted vectors had been designed. There efficient production depended on the use of helper viruses. Yet, the use of a helper virus was considered problematic by the FDA. Present purification systems do not deliver preparations with helper virus contamination levels of less than 1-in-3x1010. In this application, we therefore propose to investigate how w novel set of helper-virus independent fully deleted Adenoviral gene transfer vectors function in vivo.",81404,ZRG1,Special Emphasis Panel,A2,1,200000,
7802436,R43,AI,1,,02/15/2010,01/31/2011,PA-09-115,1R43AI085740-01,,NIAID:299993;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCKVILLE,UNITED STATES,,08,131092715,US,MD,20850,"SANARIA, INC.","HOFFMAN, STEPHEN LEV;",1982481;,1R43AI085740,02/15/2010,01/31/2012,"0-11 years old; African; Anopheles; Anopheles Genus; Attention; Attenuated; Bite; Blood; Cell Line; Cell Lines, Strains; CellLine; Cessation of life; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Culicidae; Death; Disease; Disorder; Dose; Early-Stage Clinical Trials; Fertilized Egg; Fertilized Ovums; Gametes; Germ Cells; Germ-Line Cells; Goals; Health Benefit; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human Volunteers; Human, Child; Human, General; In Vitro; Infant; Infection; Invaded; Licensure; Liver Cells; Malaria; Malaria Vaccines; Malarial Vaccines; Man (Taxonomy); Man, Modern; Marketing; Methods; Mosquitoes; Oocysts; Ovum, Fertilized; Paludism; Parasites; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Plasmodium Infections; Plasmodium falciparum; Production; Public Health; Reproductive Cells; Research; Reticuloendothelial System, Blood; SBIR; SBIRS (R43/44); Safety; Sex Cell; Small Business Innovation Research; Small Business Innovation Research Grant; Sporozoite vaccine; Sporozoites; Staging; Structure of zygote; System; System, LOINC Axis 4; Vaccines; Volunteers, Human; Zygote; adult youth; children; clinical investigation; clinical lot; commercialization; communicable disease transmission; cultured cell line; disease transmission; disease/disorder; feeding; immunogenicity; improved; infectious disease transmission; initial cell; phase 1 study; phase 1 trial; phase 2 study; phase 3 study; phase I trial; prevent; preventing; protective efficacy; protocol, phase I; public health medicine (field); public health relevance; sexual cell; tool; young adult; youngster; zygote",In-vitro culture of Plasmodium falciparum sporozoites for malaria vaccine, PROJECT NARRATIVE A highly effective malaria vaccine would have an enormous public health benefit. Sanaria's attenuated malaria sporozoite vaccine (PfSPZ Vaccine) is expected to be highly effective and will be studied in clinical trials in 2009. The PfSPZ Vaccine is manufactured in mosquitoes. This research aims to eliminate the need for mosquitoes in manufacturing the PfSPZ Vaccine.,85740,ZRG1,Special Emphasis Panel,,1,299993,
7804026,R43,AI,1,,02/01/2010,01/31/2011,PA-09-115,1R43AI085815-01,,NIAID:299999;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,174347732,US,MA,02210,"IMMUNETICS, INC.","LEVIN, ANDREW E.;",7899226;,1R43AI085815,02/01/2010,01/31/2012,"Address; Affect; Africa; African; African Sleeping Sickness; African Trypanosomiasis; American Trypanosomiasis; American trypanosome; Americas; Animals; Application procedure; Area; Armed Forces Personnel; Asia; Assay; Bacteria; Bacterial Meningitis; Base Sequence; Basic Research; Basic Science; Bioassay; Biologic Assays; Biological Assay; Biology; Blood; Categories; Causality; Cells; Chagas Disease; Characteristics; Chronic; Clinical; Complex; Cutaneous; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Disorder; Drugs, Nonproprietary; Educational Achievement; Educational Status; Ensure; Enteric Fever; Environment; Epidemiologic Monitoring; Epidemiology; Epidemiology / Surveillance; Etiology; Evolution; Family; Frequencies (time pattern); Frequency; Generations; Generic Drugs; Genome; Glass; H. influenza; H. influenzae; H.influenza; H.influenzae; Haemophilus influenzae; Home; Home environment; Human; Human Resources; Human, General; Immigrations; In-Migration; Infection; Insecta; Insects; Invertebrates, Insects; Isoenzymes; Isozymes; Kala-Azar; Laboratories; Latin America; Leishmania; Leishmania (genus); Leishmaniasis; Leishmaniasis, Visceral; Life Cycle; Life Cycle Stages; Malaria; Man (Taxonomy); Man, Modern; Manpower; Medical Surveillance; Membrane; Meningitis; Meningitis, Bacterial; Meningococcus; Methods; Methods and Techniques; Methods, Other; Microbiology, Virology, Parasitology; Military; Military Personnel; Modification; Molecular; Monitor; Monitoring, Epidemiologic; Monitoring, Epidemiological; Neisseria meningitidis; Nucleic Acids; Nucleotide Sequence; Nucleotides; Oligo; Oligonucleotide Array; Oligonucleotide Microarrays; Oligonucleotides; PCR; Paludism; Parasites; Parasitic Diseases; Parasitology; Pathogenicity; Patients; Pattern; Performance; Plasmodium; Plasmodium Infections; Polymerase Chain Reaction; Procedures; Production; Public Health; Reagent; Research; Reticuloendothelial System, Blood; Risk; Running; S. typhi; S. typhosa; S.Typhi; Salmonella enterica serovar Typhi; Salmonella typhi; Salmonella typhosa; Sampling; Services; Slide; Sorting - Cell Movement; Specificity; Staging; Streptococcus; Surveillance; Symptoms; Syndrome; T. brucei; T. cruzi; Techniques; Testing; Time; Training; Travel; Trypanosoma; Trypanosoma brucei; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosome; Trypanosomiasis; Trypanosomiasis, African; Trypanosomiasis, South American; Typhoid; Typhoid Fever; Typhoids; Typhus, Abdominal; Vector-borne disease; Vector-borne infectious disease; Vector-transmitted disease; Vector-transmitted infectious disease; Visceral Leishmaniasis; WHBLOOD; Whole Blood; analytical tool; anti-microbial; antimicrobial; assay development; base; cross reactivity; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; educational level; effective therapy; experience; flasks; flexibility; generic; health economics; life course; member; membrane structure; nucleic acid sequence; parasite genome; pathogen; personnel; prevent; preventing; public health medicine (field); public health relevance; public health research; seal; sleeping sickness; sorting; success; therapeutic vaccine; tool; training achievement; training level; training status; vector",Reverse Line Blot Assay for Trypanosome and Leishmania Detection and Identificati," Human African trypanosomiasis, American trypanosomiasis (Chagas' disease) and leishmaniasis directly affect over 30 million people in endemic regions of the Americas, Asia and Africa, while ten times that number are at risk of infection. Diagnosis and epidemiological monitoring of these diseases has been challenging due to the complex life cycles of the parasitic agents causing them, the difficulty in identifying symptoms of infection, and the cross-reactivities between many pathogen species. This project will result in the development of a molecular assay for detection and identification of the parasitic species and strains responsible for both forms of trypanosomiasis and leishmaniasis. Earlier and more accurate detection and identification than is possible with current methods will enable clinicians to select more effective antimicrobial therapy for patients, and will contribute to epidemiological monitoring and surveillance of the spread of these parasitic agents.",85815,ZRG1,Special Emphasis Panel,,1,299999,
7911350,R43,AI,1,,02/01/2010,01/31/2011,PA-09-115,1R43AI088952-01,,NIAID:300000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCKVILLE,UNITED STATES,,08,125129606,US,MD,208506332,"SEQUELLA, INC.","EINCK, LEO ;",1930653;,1R43AI088952,02/01/2010,01/31/2012,"1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (S-(R*,R*))-; 1-cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 4 ASA; 4-Aminosalicylic Acid; 4-Pyridinecarbothioamide, 2-ethyl-; 4-Pyridinecarboxylic acid, hydrazide; Amidazine; Amikacin; Amikin; Amiklin; Amukin; Animals; Antibiotics, Antitubercular; Antitubercular Agents; Antitubercular Antibiotics; Antitubercular Drugs; Apothecon Brand of Amikacin Sulfate; Bacterial Infections; Benemycin; Benzoic acid, 4-amino-2-hydroxy-; Biclin; Biklin; Bristol-Myers Squibb Brand of Amikacin Sulfate; Capreomycin; Capromycin; Cessation of life; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Combination Drug Therapy; Communicable Diseases; Cycloserine; D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-; D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-; Data; Death; Disease; Disorder; Dose; Drug Combinations; Drug Exposure; Drug Kinetics; Drug Resistance, Multiple; Drug Resistant Tuberculosis; Drug Resistant, Multiple; Drug Therapy; Drug resistance; Drug usage; Drug-sensitive; Drugs; Ethambutol; Ethionamide; Ethioniamide; Evaluation; Extreme drug resistant tuberculosis; Extremely drug resistant tuberculosis; Genus Mycobacterium; Health; Human; Human, General; In Vitro; Incidence; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Isonicotinic Acid Hydrazide; Kanamycin; Killings; Laboratories; Lung; Lung TB; Lung Tuberculosis; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Mammals, Mice; Man (Taxonomy); Man, Modern; Mead Johnson Brand of Amikacin Sulfate; Medication; Mice; Microorganisms, General; Moxifloxacin; Multi-Drug Resistance; Multidrug Resistance; Multidrug-Resistant Tuberculosis; Murine; Mus; Mycobacterium; Mycobacterium tuberculosis; NIAID; National Institute of Allergy and Infectious Disease; Natural Resistance; PAS; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Pharmacology; Pharmacotherapy; Phase; Phenotype; Polychemotherapy; Population; Predisposition; Procedures; Protocols, Treatment; Pulmonary TB; Pulmonary Tuberculosis; Pyrazinamide; Pyrazinecarboxamide; R-4-Amino-3-isoxazolidinone; RGM; Regimen; Reporting; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Respiratory System, Lung; Reticuloendothelial System, Spleen; Rifadin; Rifampicin; Rifampicin resistance; Rifampicin resistant; Rifampin; Rifampin resistance; Rifampin resistant; Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-; Rimactane; SBIR; SBIRS (R43/44); Safety; Small Business Innovation Research; Small Business Innovation Research Grant; Spleen; Susceptibility; Time; Toxicology; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tuberculosis; Tuberculosis, Drug Resistance; Tuberculosis, Drug Resistant; Tuberculosis, MDR; Tuberculosis, Multi-Drug Resistant; Tuberculosis, MultiDrug Resistance; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tuberculostatic Agents; WHO; Work; World Health Organization; XDR-Tuberculosis; anti-microbial; anti-tuberculosis; antimicrobial; antituberculosis; bacterial disease; base; chemotherapy; clinical investigation; combination pharmacotherapy; design; designing; disease/disorder; disseminated TB; disseminated tuberculosis; drug candidate; drug efficacy; drug resistant; drug use; drug/agent; improved; in vitro activity; in vivo; intervention development; isoniazid; microorganism; mouse model; multi-drug resistant; multidrug resistant; p aminosalicylate; p-Aminosalicylic Acid; para-Aminosalicylic Acid; particle; pre-clinical; preclinical; public health relevance; pulmonary; resistance to Drug; resistant; resistant strain; resistant to Drug; response; safety study; small molecule; standard care; standard of care; therapy development; treatment development; tuberculosis drugs; tuberculosis treatment; tuberculous spondyloarthropathy",SQ109 for treatment of MDR-TB," Project Narrative: SQ109 is an orally active drug and a new drug candidate in clinical development for the treatment of all forms of tuberculosis (TB), including multi-drug resistant (MDR) and extreme drug resistant (XDR) TB. TB is a contagious bacterial infection caused by Mycobacterium tuberculosis (MTB) transmitted from person to person by airborne particles. TB kills more people than any other single etiologic agent, and yet the drugs used to treat this infectious disease are so ineffective that a combination of drugs given for six months is the standard treatment regimen for uncomplicated drug-sensitive TB. The National Institute of Allergy and Infectious Diseases (NIAID) and World Health Organization (WHO) recognize TB as one of the most serious health problems in the world. Two billion (one third) of the world's population are infected with TB. The estimated incidence of TB disease was more than 9 million worldwide in 2007, and these newly identified active infections resulted in nearly 2 million deaths. WHO reports that over 450,000 of these TB cases had MDR-TB. The WHO and the U.S. FDA are encouraging pharmaceutical companies to develop new TB drugs for MDR-TB, citing the rising numbers of patients and the critical need for new effective drugs for MDR-TB. A clinical trial to establish new drug efficacy for treating MDR-TB will compare a group of MDR-TB patients treated with a standard of care dose regimen selected from the 2nd line TB drugs with a seconf group of MDR-TB patients treated with the new drug plus the same standard of care regimen used in the first group. To correctly design a new regimen for MDR-TB, the clinical trials will benefit from an understanding of how well the drugs work together in humans (pharmacokinetics, interactions) and how efficacious the new regimen is (antimicrobial efficacy of drug combinations). This study proposes to examine the interaction of SQ109 with selected 1st and 2nd line TB drugs.",88952,ZRG1,Special Emphasis Panel,,1,300000,
7802402,R43,DA,1,,02/01/2010,01/31/2011,PA-09-080,1R43DA026224-01A2,,NIDA:199845;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEWTON,UNITED STATES,,04,796369155,US,MA,024641954,"INFLEXXION, INC.","TRUDEAU, KIMBERLEE JEAN;",8877567;,1R43DA026224,02/01/2010,01/31/2011,"Address; Advertising; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Climate; Communities; Consensus; Development; Development Plans; Drug Controls; Drug Prescribing; Drug Prescriptions; Drugs; Effectiveness; FDA; Feedback; Food and Drug Administration; Food and Drug Administration (U.S.); Goals; Grant; Intervention; Intervention Strategies; Interview; Knowledge; Link; Maintenance; Maintenances; Maps; Medication; Meteorological Climate; Methods; Opioid; Perception; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Plans, Development; Policies; Populations at Risk; Preparedness; Prescriptions, Drug; Prevention; Prevention education; Preventive Intervention; Programs (PT); Programs [Publication Type]; Public Health; Readiness; Reporting; Reportings, Hospital Risk; Research Resources; Resources; Risk; Risk Management; Risk Reporting, Hospital; SAMHSA; Sight; Site; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Survey Instrument; Surveys; Testing; USFDA; United States Food and Drug Administration; United States Substance Abuse and Mental Health Services Administration; Vision; analgesia; base; climatic; drug abuse prevention; drug addiction prevention; drug use prevention; drug/agent; indexing; innovate; innovation; innovative; interest; interventional strategy; member; opioid misuse; prescription drug abuse; preventional intervention strategy; programs; public health medicine (field); public health relevance; tool; willingness",PRESCRIPTION: INTERVENTION--A COALITION PLANNING TOOL FOR PAINKILLER MISUSE," COALITION GRANT PHASE I 7. Project Narrative Prescription pain reliever misuse and abuse is a growing national issue that requires immediate, targeted intervention. Community anti-drug coalitions know about both local needs and resources; therefore, we propose to test the feasibility of a new online program: CAP: The Coalition Action Planner. CAP would help coalitions by providing a) an online survey to assess community willingness to participate in prescription pain reliever prevention and intervention and b) survey feedback and related tools to help coalitions mobilize communities towards action in a timely and effective manner",26224,ZRG1,Special Emphasis Panel,A2,1,199845,
7803413,R43,DA,1,,02/01/2010,01/31/2011,PA-09-080,1R43DA027190-01A1,,NIDA:231565;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEWTON,UNITED STATES,,04,796369155,US,MA,024641954,"INFLEXXION, INC.","DONOVAN, ELIZABETH ANNA;",9422249;,1R43DA027190,02/01/2010,01/31/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Accounting; Address; Age; Alcohols; American; Amphetamines; Area; Behavioral; Care, Health; Chemical Class, Alcohol; Cocaine; Communities; Community Education; Community Health; Community Health Education; Community Health Taining; Community HealthTutoring; Consultations; Country; Development Plans; Drug Prevention Program; Drug usage; Drugs; Enrollment; Equilibrium; Feedback; Goals; Health; Health Education, Community; Health Resources; Healthcare; High Prevalence; Individual; Internet; Intervention; Intervention Strategies; Interview; Knowledge; Lead; Learning; Life; Link; Literature; Marijuana Smoking; Medication; Modeling; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Plans, Development; Population; Prevention; Programs (PT); Programs [Publication Type]; Public Health; Research Design; Research Resources; Resources; Self Efficacy; Site; Smoke; Smoking; Stress; Students; Study Type; Technology; Testing; WWW; Work; alcohol and other drug; balance; balance function; base; binge alcohol consumption; binge drinking; college; college student; community intervention; cost; cost effective; design; designing; disease risk; disorder risk; drug use; drug/agent; enroll; episodic drinking; experience; heavy metal Pb; heavy metal lead; high risk; improved; innovate; innovation; innovative; interventional strategy; meetings; programs; psychosocial; public health medicine (field); public health relevance; skills; socioeconomic; socioeconomically; socioeconomics; study design; tool; university student; usability; web; web site; world wide web",MyStudentBody-Community College: A Health Website for Students," MYSTUDENTBODY-COMMUNITY COLLEGE PHASE I 7. Project Narrative  Currently, 11.5 million students, 46% of all US undergraduates, are enrolled at community colleges. This college population is, arguably, in the greatest need of wellness and AOD prevention programming; however, community college students are offered very few, if any, health resources. We propose to develop an interactive, online wellness and AOD prevention website, which, if successful, will have a significant public health impact by improving the health of community college students.",27190,ZRG1,Special Emphasis Panel,A1,1,231565,
7746973,R43,DA,1,,02/01/2010,01/31/2011,PA-08-050,1R43DA027304-01,,NIDA:649545;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,AUBURN,UNITED STATES,,09,114845659,US,WA,98001,"SYNTRIX BIOSYSTEMS, INC.","KAHN, STUART J (contact);ZEBALA, JOHN A;",1892924 (contact);6769125;,1R43DA027304,02/01/2010,01/31/2011,"Absence of pain sensation; Absence of sensibility to pain; Addiction, Opiate; Adopted; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Binding; Binding (Molecular Function); Blood Plasma; Blood Serum; CYP 2D6; CYPIID6; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Chemistry; Clinical; Conduct Clinical Trials; Controlled Clinical Trials; Country; Cyclic GMP; Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-; Cytochrome P-450 CYP2D6; Cytochrome P450 2D6; Cytochrome P450 Subfamily IID Polypeptide 6; Cytochrome P450, Subfamily IID; Cytochrome P450, Subfamily IID-Like 1; Data; Debrisoquine 4-Hydroxylase; Debrisoquine 4-Monooxygenase; Debrisoquine Hydroxylase; Dependence, Opiate; Documentation; Dose; Drug Formulations; Drug Kinetics; Drugs; Drugs, Nonproprietary; Electronics; Elements; Feels no pain; Formulation; Formulations, Drug; Generic Drugs; Genotype; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Human; Human, General; Imipramine 2-Hydroxylase; Individual; Isoenzymes; Isozymes; Man (Taxonomy); Man, Modern; Marketing; Medication; Molecular Interaction; No sensitivity to pain; Nociceptive Impulse; Nociceptive Stimulus; Occidental; Opiate Addiction; Opioid; Opioid Receptor; P450-2D6; P450DB1; Pain; Painful; Parents; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phase; Phenotype; Physicians; Plasma; Population; Process; Production; Receptors, Opiate; Resistance; Reticuloendothelial System, Serum, Plasma; Risk; SBIR; SBIRS (R43/44); Safety Management; Sales; Science of Chemistry; Serum; Serum, Plasma; Small Business Innovation Research; Small Business Innovation Research Grant; Sparteine Monooxygenase; Spinal; Tablets; Therapeutic Index; Time; Tramadol; analgesia; base; cGMP; disability; drug/agent; generic; guanosine 3'5' monophosphate; improved; opioid addiction; opioid dependence; phase 2 study; public health relevance; resistant; tablet (pharmacologic); tool; white race",Overcoming Tramadol Resistance In CYP2D6 Poor Metabolizers," Pain is a leading cause of human disability effecting ~1% of the population. Tramadol is a widely prescribed pain medication that was prescribed 18,526,000 times in 2007. An important advantage of tramadol is its lower risk of opioid dependence. Approximately 10% of Caucasians can not use tramadol because they fail to process the drug appropriately. This project will develop a new, improved tramadol that can be processed by all people for their benefit.",27304,ZRG1,Special Emphasis Panel,,1,649545,
7802476,R43,DA,1,,03/01/2010,12/31/2010,PA-09-080,1R43DA028016-01,,NIDA:286830;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,EUGENE,UNITED STATES,,04,783579782,US,OR,97401,"OREGON CENTER FOR APPLIED SCIENCE, INC.","RODE, CATRIN ;",8406199;,1R43DA028016,03/01/2010,12/31/2010,"AOD use; Academic achievement; Adopted; Age; Age Group Unspecified; Alcohol abuse; Alcohol or Other Drugs use; Alcohols; Attitude; Behavior-Related Disorder; Behavior-Related Problem; Behavioral; CD-ROM; CD-ROM (Compact Disc-Read Only Memory); CDROM; Characteristics; Chemical Class, Alcohol; Code; Coding System; Cognitive Science; Compact Disk Read-Only Memory; Competence; Computers; Drops; Drug usage; Drugs; Drugs, Illicit; Educational process of instructing; Effectiveness, Program; Emotional disorder; Ensure; Environment; FLR; Failure (biologic function); Flow Charts (Computer); Flowchart (Computer); Flowcharts; Focus Groups; Fostering; Goals; Habits; Illicit Drugs; Individual; Internet; Intervention; Intervention Strategies; Interview; Knowledge; Learning; Lifestyle-Related Disorder; Lifestyle-Related Problem; Lifestyle-related condition; Measures; Medication; Methods and Techniques; Methods, Other; Modeling; NIDA; National Institute of Drug Abuse; On-Line Systems; Online Systems; Parents; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Preparation; Prevention; Prevention program; Problem behavior; Process; Program Development; Program Effectiveness; Programs (PT); Programs [Publication Type]; Public Health; Randomized Controlled Trials; Research; Retrieval; Risk; Risk Factors; Sampling; Schools; Students; Substance abuse problem; Teaching; Techniques; Testing; Time Study; TimeLine; Tobacco Consumption; Tobacco use; United States; WWW; Writing; Youth; Youth 10-21; abuse of substances; adolescent drug use; age group; alcohol problem; anti social; antisocial; base; behavioral problem; cognitive psychology; cost; design; designing; drug abuse prevention; drug addiction prevention; drug use; drug use prevention; drug/agent; ethanol abuse; evidence base; experience; failure; follow up assessment; habit learning; hazardous alcohol use; high school; improved; interactive multimedia; interpersonal competence; interpersonal competency; interventional strategy; long term memory; ninth grade; online computer; peer; prevent; preventing; problem drinking; programs; prototype; public health medicine (field); public health relevance; randomized controlled study; randomized trial; skills; social competence; social competency; social skills; substance abuse; substance use; success; teacher; tool; tool development; usability; web; web based; world wide web; youth drug use",Preventing Drug Use: Interactive Program to Improve Academic Skills, NARRATIVE  This project has the potential to support at risk youth by teaching evidence-based learning strategies that promote academic success which is known to be an important protective factor for substance abuse and other problem behavior.,28016,ZRG1,Special Emphasis Panel,,1,286830,
7804875,R43,EB,1,,02/01/2010,07/31/2010,PA-09-080,1R43EB010342-01,,NIBIB:100000;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NORTHRIDGE,UNITED STATES,,27,153098871,US,CA,91324,"DXRAY, INC.","HARTSOUGH, NEAL EUGENE;",7532676;,1R43EB010342,02/01/2010,07/31/2010,"2,5-di-t-amyl-p-benzoquinone; 2,5-di-tert-pentyl-p-benzoquinone; Area; Cadmium; Cd element; Cd-Te; Characteristics; Charge; Collection; Conventional X-Ray; Coupled; Custom; DAQ; Deposit; Deposition; Detection; Devices; Diagnostic Radiology; Diagnostic radiologic examination; Digital Mammography; Equipment; Figs; Figs - dietary; Film; Fluoroscopy; Generalized Growth; Glass; Goals; Growth; HgI2; Housing; Image; Japan; Korea; MMG; Mammogram; Mammography; Manufacturer; Manufacturer Name; Marketing; Measures; Medical Imaging, X-Ray; Methods; Noise; Output; PCBs; Performance; Phase; Physics; Polychlorinated Biphenyls; Polychlorobiphenyl Compounds; Powder dose form; Powders; Power Sources; Power Supplies; Price; Printing; Process; Property; Property, LOINC Axis 2; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Radiography; Radiology, Diagnostic X-Ray; Reporting; Research; Research Design; Resolution; Risk; Roentgen Rays; Roentgenography; Se element; Selenium; Side; Slide; Source; Speed; Speed (motion); Study Type; Surface; System; System, LOINC Axis 4; Technology; Temperature; Testing; Thick; Thickness; Tissue Growth; Transistors; Work; Writing; X-Radiation; X-Ray Imaging; X-Ray, Diagnostic; X-Rays; Xrays; Zinc; Zn element; base; cadmium telluride; cost; cost effective; design; designing; detector; experience; imaging; imaging detector; imaging modality; improved; indium tin oxide; interest; meetings; mercuric diiodide; mercuric iodide; mercuric iodide, red; mercury iodide (HgI2); ontogeny; polychlorobiphenyl; pricing; public health relevance; quantum; red mercuric iodide; response; solid state; study design; sublimation",Low-cost Large-area High-Sensitivity X-ray Panel Detector for Digital Mammography," Project Narrative  We will grow a high-sensitivity detector material, cadmium zinc telluride (CZT), directly onto CMOS technology megapixel readouts. This will achieve significant breakthroughs in x-ray imaging panel detector price and performance. Mammography will benefit due to the improved spatial resolution and reduced cost from this unique combination of detector material and readout.",10342,ZRG1,Special Emphasis Panel,,1,100000,
7801418,R43,ES,1,,01/19/2010,12/31/2010,PA-09-006,1R43ES018004-01,,NIEHS:130000;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BIRMINGHAM,UNITED STATES,,07,168161532,US,AL,352054709,"VIVO BIOSCIENCES, INC.","SINGH, RAJ K.;",1971943;,1R43ES018004,01/19/2010,12/31/2010,"2-dimensional; 3-D; 3-Dimensional; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Au element; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cancer Drug; Cell Culture Techniques; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cell-Extracellular Matrix; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemical Agents; Chemotherapeutic Agents, Neoplastic Disease; Clinical Evaluation; Clinical Testing; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen; Development; Diagnostics Research; Drug toxicity; Drugs; ECM; ENTACTIN; Environment; Esteroproteases; Exhibits; Expression Profiling; Expression Signature; Extracellular Matrix; Future; GFAC; Generalized Growth; Genomics; Glycoprotein GP-2; Goals; Gold; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hepatotoxic effect; Hepatotoxicity; Hour; Human; Human Development; Human, General; Hydrogels; In Vitro; Intermediary Metabolism; Laminin; Legal patent; Liver; Liver Cells; Liver Toxicity; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Marketing; Medication; Metabolic; Metabolic Processes; Metabolism; Methods; Mice; Microscopy; Modeling; Molecular; Molecular Analysis; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; NID; NID gene; NID1; Nature; Oncogenesis; Patents; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic; Physiological; Polymers; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteoglycan; Proteolytic Enzymes; Proteomics; Protocol; Protocols documentation; Real-Time Systems; SBIR; SBIRS (R43/44); Sales; Slice; Small Business Innovation Research; Small Business Innovation Research Grant; Social Support System; Study models; Subcellular Process; Support System; System; System, LOINC Axis 4; Systems, Real-Time; Technology; Time; Tissue Growth; Toxic effect; Toxic effect on liver cells; Toxicities; Toxicogenomics; Tumor-Derived; Tumor-Specific Treatment Agents; Validation; abstracting; anticancer agent; anticancer drug; base; biomarker; body system, hepatic; cell type; clinical test; design; designing; drug discovery; drug metabolism; drug/agent; hepatoxicity; improved; in vivo; liver function; matrigel; molecuar profile; molecular signature; novel; ontogeny; organ system, hepatic; pre-clinical; pre-clinical research; preclinical; preclinical research; public health relevance; research clinical testing; scaffold; scaffolding; tool; tumorigenesis; two-dimensional",New In Vitro Human Liver Toxicity Bioassay System," Project Narrative: Current cell-based assay models for studying drug metabolism & toxicity are of limited utility because liver cells die rapidly in their non-physiologic, 2-dimensional (2D) culture formats. Our company has recently created a novel human biomatrix system- HuBiogel""which supports long term 3-dimensional (3D) growth, survival and organization of a variety of cell types. We propose to employ unique HuBiogel and a NASA-developed rotary culture technology to develop a new 3D human liver bioassay that greatly extends liver cell survival & function beyond current culture methods, providing a much needed tool for real-time analysis of drug metabolism & toxicity in vitro. Cells isolated from donor human livers are the gold standard for pre-clinical evaluation of drug metabolism profiles and potential hepatotoxicity. Unfortunately, these cells lose function and die within hours in traditional cell culturing techniques. The proposed development of human matrix-based 3D bioassay system supporting long-term survival & function of liver cells will have a world-wide market, both as a research and diagnostic tool.",18004,ZRG1,Special Emphasis Panel,,1,130000,
7801106,R43,GM,1,,01/04/2010,12/31/2010,PA-08-114,1R43GM087755-01A2,,NIGMS:334910;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,08,827056362,US,CA,941582330,"PHOTOSWITCH BIOSCIENCES, INC.","BLATZ, ANDREW ;",9549461;,1R43GM087755,01/04/2010,12/31/2010,"Address; Adoption; Affect; Arrhythmia; Arts; Assay; Behavior; Bioassay; Biologic Assays; Biological Assay; Blood Pressure, High; Brain; Cardiac Arrhythmia; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular Membrane; Charge; Coloring Agents; Communities; Cultured Cells; Cystic Fibrosis; Data; Detection; Development; Device or Instrument Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Dyes; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Event; Gated Ion Channel; Glutamate Receptor; Goals; Heart; Heart Arrhythmias; Hypertension; Illumination; Ion Channel; Ion Channels, Potassium; Ionic Channels; Ions; K channel; Light; Lighting; Liquid substance; Mammalian Cell; Medication; Membrane Channels; Membrane Potentials; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Movement; Mucoviscidosis; Muscle; Muscle Tissue; Muscular Dystrophies; Myodystrophica; Myodystrophy; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurophysiology / Electrophysiology; Operation; Operative Procedures; Operative Surgical Procedures; Optical Methods; Optics; Outcome; Pathology; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Photoradiation; Physiologic; Physiological; Potassium Channel; Price; Property; Property, LOINC Axis 2; Proteins; Research Resources; Resources; Rest; Resting Potentials; Screening procedure; Slice; Solutions; Stretching; Surface Proteins; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Technology; Testing; Therapeutic Intervention; Time; Transmembrane Potentials; V (voltage); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Voltage-Clamp Technics; Voltage-Clamp Technique; Work; assay development; base; body movement; cell type; cultured cell line; device development; disease/disorder; drug discovery; drug/agent; experiment; experimental research; experimental study; fluid; gene product; hyperpiesia; hyperpiesis; hypertensive disease; instrument; instrument development; interest; intervention therapy; light gated; liquid; nano machine; nanomachine; neuronal; novel; patch clamp; pricing; public health relevance; research study; response; screening; screenings; stable cell line; success; surgery; voltage",Ion Channel Drug Discovery Using Photoswitch Technology," Many diseases involve problems with the functioning of membrane proteins called ion channels. These proteins are responsible for proper operation of the nervous system, the muscles, and virtually all other physiological events. Drugs that affect ion channel behavior have been developed for a variety of diseases, including heart problems, cystic fibrosis, and other diseases. Ion channels are difficult to study and, because of this, drugs directed at ion channels have been difficult to find. Photoswitch Biosciences proposes to develop methods to increase the ability to study ion channels, and, thus, to increase the number of ion channel drugs.",87755,ZRG1,Special Emphasis Panel,A2,1,334910,
7801581,R43,GM,1,,01/01/2010,12/31/2010,PAR-07-160,1R43GM090343-01,,NIGMS:175768;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ST. JOSEPH,UNITED STATES,,06,113429489,US,MI,49085,"GENEGO, INC.","BUGRIM, ANDREJ ;",8085675;,1R43GM090343,01/01/2010,12/31/2011,"Algorithms; Biological; Cancer cell line; Carcinoma Cell; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Clinical; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Data; Data Set; Dataset; Diagnostic; Disease Progression; Drug resistance; Drugs; EGF; EGF gene; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Evaluation; Expression Profiling; Expression Signature; Family; Gene Expression; Gene Proteins; Goals; HER1; Heterogeneity; Individual; Intracellular Communication and Signaling; Knowledge; Lead; Malignant Epithelial Cell; Medication; Method LOINC Axis 6; Methodology; Methods; Modeling; Molecular; Molecular Diagnostic Methods; Molecular Diagnostic Technics; Molecular Diagnostic Techniques; Molecular Fingerprinting; Molecular Profiling; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Network Analysis; Network-based; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Pathway Analysis; Pathway interactions; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Procedures; Process; Protein Gene Products; Proteins; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Regulatory Protein; Resistance; Sampling; Scoring Method; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Staging; System; System, LOINC Axis 4; Technology; Testing; Training; Transforming Growth Factor alpha Receptor; URG; Validation; Weight; Work; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; clinical investigation; cohort; combination therapy; combined modality treatment; combined treatment; computer based prediction; cultured cell line; drug resistant; drug sensitivity; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; knowledge base; molecuar profile; molecular signature; multimodality therapy; network models; nonsmall cell lung cancer; novel; pathway; performance tests; predictive modeling; process optimization; protein expression; proto-oncogene protein c-erbB-1; public health relevance; receptor; regulatory gene product; resistance to Drug; resistant; resistant to Drug; response; success; therapeutic target",Regulation signatures for predicting drug resistance and its molecular mechanisms," In this project we will develop novel ""regulation signatures"" to predict sensitivity to the inhibitors of EGF receptor and identify mechanisms of drug resistance. Project will utilize public gene expression data in combination with knowledge base on protein interactions and our recently developed network analysis algorithm. If successful, the methodology could lead to a number of diagnostic applications.",90343,BCHI,Biomedical Computing and Health Informatics Study Section,,1,175768,
7801336,R43,GM,1,,01/01/2010,12/31/2010,PA-07-451,1R43GM090392-01,,NIGMS:251293;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,170943737,US,CA,920374613,"PROGNOSYS BIOSCIENCES, INC.","KOZLOV, IGOR A.;",8925489;,1R43GM090392,01/01/2010,12/31/2011,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; Amino Acid Sequence; Assay; Bacteriophages, RNA; Bioassay; Biologic Assays; Biological; Biological Assay; Biotin; Cells; Code; Coding System; Complementary DNA; Custom; DNA; DNA Chips; DNA Library; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA bank; DNA, Complementary; Deoxyribonucleic Acid; Detection; Development; Diagnosis; Diagnostic; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7; Enzymes; Fungal Genome; Gene Products, RNA; Gene Transcription; Generations; Genetic Transcription; Genome; Genome, Fungal; Genomics; Goals; In Vitro; Individual; Kinases; Label; Link; Medical; Methods; Methods and Techniques; Methods, Other; Modeling; Oligo; Oligonucleotides; Peptide Synthesis; Peptides; Phase; Phosphates; Phosphorylated Peptide; Phosphorylation; Phosphotransferases; Protein Analysis; Protein Phosphorylation; Protein Structure, Primary; Proteins; Proteome; Protocol; Protocols documentation; RNA; RNA Expression; RNA Phages; RNA, Non-Polyadenylated; Random Peptide Libraries; Ribonucleic Acid; Role; Sampling; Screening procedure; Solid; Spottings; Strepavidin; Streptavidin; Structure; Substrate Specificity; Surface; Techniques; Technology; Time; Transcription; Transcription, Genetic; Translation Process; Transphosphorylases; Vitamin H; Yeasts; base; cDNA; chemical synthesis; coenzyme R; cost; design; designing; digital; disease/disorder; drug development; experiment; experimental research; experimental study; gene product; genome-wide; inorganic phosphate; interest; magnetic beads; new approaches; new technology; next generation; novel; novel approaches; novel strategies; novel strategy; protein sequence; public health relevance; research study; screening; screenings; social role; tool; yeast genome",New Technology for Functional Studies of the Kinome," The kinase substrate screening technology we are developing will help to enable large- scale studies of kinases. This is useful for identifying new drug targets and for drug development. It would help to guide experiments to elucidate the functional roles of specific kinases and may also prove to be a sensitive diagnostic tool, and therefore may result in medical advances in the diagnosis and treatment of disease.",90392,ZRG1,Special Emphasis Panel,,1,251293,
7803170,R43,HD,1,,02/01/2010,07/31/2010,PA-09-080,1R43HD062025-01A1,,NICHD:100000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,WOODMERE,UNITED STATES,,04,101398662,US,NY,11598,"PAGEFLIP, INC.","SCHIPPER, IRENE SANDRA;",6838905;,1R43HD062025,02/01/2010,07/31/2010,"ALS; Activities of Daily Living; Activities of everyday life; Address; Adhesives; Aged 65 and Over; Amyotrophic Lateral Sclerosis; Apoplexy; Arm; Arthritis; Articulation; Assistive Technology; Award; Bilateral; Books; Cerebral Palsy; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chin; Communities; Development Plans; Devices; Disabled Persons; Disabled Population; Document Type; Elderly; Elderly, over 65; Electronics; Employee Strikes; Equipment; Exercise; Exercise, Physical; FLR; Failure (biologic function); Foot; Friction; Future; Gehrig's Disease; Goals; Grant; Hand; Handicapped; Hospital Nursing; Impairment; Individual; Joints; Latex Rubber; Learning; Legal patent; Libraries; Location; Lou Gehrig Disease; MS (Multiple Sclerosis); Marketing; Measures; Mechanics; Membrum superius; Mentum; Modeling; Motion; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Multiple Sclerosis; Musculoskeletal; Music; Musics; Myelopathy, Traumatic; Neurologic; Neurological; Nursing Homes; Operation; Operative Procedures; Operative Surgical Procedures; Paper; Patents; Patients; Penetration; People with Disabilities; Performance; Persons with Disabilities; Pes; Phase; Plans, Development; Population; Pressure; Pressure- physical agent; Process; QOL; Quality of life; Reader; Reading; Report (document); Reporting; Role; Rotation; Rubber; Rubber, natural; SBIR; SBIRS (R43/44); Sclerosis, Disseminated; Self-Help Devices; Side; Small Business Innovation Research; Small Business Innovation Research Grant; Solutions; Speed; Speed (motion); Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Strikes; Strikes, Employee; Stroke; Surface; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Technology; Testing; Time; Travel; Upper Extremity; Upper Limb; Upper arm; Vascular Accident, Brain; Voice; Weight; Wireless Technology; advanced age; arthritic; assistive device; base; brain attack; cerebral vascular accident; cost; daily living functionality; design; designing; disability; disabled; disabled people; elders; experiment; experimental research; experimental study; failure; foot; functional ability; functional capacity; geriatric; improved; insular sclerosis; late life; later life; musician; new approaches; novel; novel approaches; novel strategies; novel strategy; nursing home; older adult; older person; portability; pressure; prototype; public health relevance; research study; senior citizen; social role; stroke; success; surgery; wireless",Hands-Free Assistive Reading Technology for Persons with Disabilities,"  An automatic page turner would be particularly beneficial to people with limited upper extremity function caused by neurological impairment, musculoskeletal problems, and generalized weakness. Included in this population, for example, are patients who have suffered cerebrovascular accidents, spinal cord injuries, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cerebral palsy, and arthritic joint changes. The proposed device would serve to enhance their quality of life by improving their independence in this activity of daily living. Furthermore, successful penetration of large consumer markets consisting of musicians and avid readers will offer economies of scale that would significantly lower cost and facilitate pervasive use. This can enable the device to become convenient attachments to pianos, music stands, book stands, and exercise equipment, in addition to its role as an assistive technology in hospitals, nursing homes, and libraries.",62025,ZRG1,Special Emphasis Panel,A1,1,100000,
7801119,R43,HL,1,,01/15/2010,01/04/2011,PA-09-080,1R43HL096155-01A1,,NHLBI:265823;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MALVERN,UNITED STATES,,06,190641816,US,PA,19355,"PROGENRA, INC.","GOLDENBERG, SETH ;",8830675;,1R43HL096155,01/15/2010,01/04/2011,"ADME Study; APF-1; ATP-Dependent Proteolysis Factor 1; Absorption, Distribution, Metabolism, and Excretion Study; Accelerated interstitial pneumonitis; Acute Interstitial Pneumonitis; Affinity Chromatography; Anger; Assay; Bioassay; Biologic Assays; Biological Assay; Bleo; Bleomycin; Bleomycin Antibiotic; Cancers; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cell model; Cell-Mediated Cytolysis; Cell-Mediated Lympholysis; Cells; Cellular Cytotoxicity; Cellular Proliferation; Cellular model; Chemical Structure; Chemistry, Pharmaceutical; Chromatography, Affinity; Collaborations; Collagen; Cytoplasm; Cytotoxicity, Immunologic; Deposit; Deposition; Desquamative interstitial pneumonitis; Detection; Development; Disease; Disease Pathway; Disorder; Diversity Library; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Kinetics; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Esteroproteases; Evaluation; Fibrosing Alveolitis; Fibrosis; Forecast of outcome; Genetic Alteration; Genetic Change; Genetic defect; Goals; HMG-20; Hamman-Rich syndrome; High Mobility Protein 20; High Throughput Assay; Idiopathic ARDS; Idiopathic Interstitial Pneumonia; Intracellular Communication and Signaling; Lead; Libraries; Link; Lundbeck Brand of Bleomycin Sulfate; Lung; Lymphocyte Cytotoxicity; Lymphocytotoxicity; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Medicinal Chemistry; Mice; Modeling; Murine; Mus; Mutation; Non-specific interstitial neumonia/fibrosis; Nuclear; Nucleus; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Pharmaceutic Chemistry; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceuticals; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Phase; Play; Prognosis; Proteases; Proteinases; Proteolytic Enzymes; Publishing; Pulmonary Fibrosis; Respiratory System, Lung; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Technology; Therapeutic; Therapeutic Agents; Therapeutic Effect; Therapeutic Intervention; Ubiquitin; Universities; Usual Interstitial Pneumonia; Usual Interstitial Pneumonitis; Validation; WNT Signaling Pathway; WNT signaling; Work; affinity purification; angers; angry; base; biological signal transduction; cancer cell; cell mediated cytotoxicity; de-ubiquitinase; de-ubiquitinating enzyme; diffuse interstitial pulmonary fibrosis; disease/disorder; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; high throughput screening; human disease; idiopathic pulmonary fibrosis; in vivo Model; inhibitor; inhibitor/antagonist; intervention therapy; isopeptidase; malignancy; neoplasm/cancer; new therapeutic target; novel; outcome forecast; pathway; pre-clinical; preclinical; public health relevance; pulmonary; research study; small molecule; small molecule libraries; social role; therapeutic target; ubiquitin isopeptidase; ubiquitin-specific isopeptidase",USP34 as a novel target for treatment of idiopathic pulmonary fibrosis,"  The WNT/ss-catenin signaling pathway has been linked to various human diseases, including cancer and Idiopathic Pulmonary Fibrosis (IPF). For these diseases, inhibitors of WNT signaling are potentially useful as therapeutic agents. Progenra proposes to collaborate with academic experts in the WNT pathway and lung fibrosis to discover inhibitors of an enzyme called USP34, which acts to increase WNT signaling in IPF. Inhibitors of USP34 will be identified in high throughput screening using Progenra's assay technology and evaluated for preclinical development as therapeutic agents to treat IPF.",96155,ZRG1,Special Emphasis Panel,A1,1,265823,
8002381,R56,DK,1,Y,01/19/2010,12/31/2010,PA-07-070,1R56DK080128-01A1,,NIDDK:229500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,RICHARDSON,UNITED STATES,CHEMISTRY,03,800188161,US,TX,750801407,UNIVERSITY OF TEXAS DALLAS,"AHN, JUNG-MO ;",8238750;,1R56DK080128,01/19/2010,12/31/2010,"Accounting; Affinity; Architecture; Benzamides; Binding; Binding (Molecular Function); Bioavailability; Biochemical; Biochemical Pathway; Biologic Availability; Biological; Biological Availability; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Development; Diabetes Mellitus; Engineering; Engineering / Architecture; Engineerings; Face; GLP-1; GLP-1 receptor; GLP-I receptor; Gastrointestinal Tract, Pancreas; Length; Ligands; Link; Mediating; Metabolic Networks; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Oral; Pancreas; Pancreatic; Peptides; Physiologic; Physiologic Availability; Physiological; Play; Predisposition; Proteins; Receptor Protein; Reporting; Research; Role; Seminal; Side; Single Crystal Diffraction; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Structure; Subcellular Process; Surface; Susceptibility; Techniques; Therapeutic; X Ray Crystallographies; X-Ray Crystallography; amphiphilicity; base; bioavailability of drug; biological systems; blood glucose regulation; design; design and construction; designing; diabetes; facial; functional group; gene product; glucagon-like peptide 1; glucagon-like peptide-1 receptor; glucose control; glucose homeostasis; glucose regulation; human disease; improved; in vivo; insulin secretion; interest; mimetics; mimicry; new therapeutics; next generation therapeutics; novel; novel therapeutics; peptide hormone; peptide structure; peptidomimetics; pharmacophore; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; protein complex; prototype; receptor; scaffold; scaffolding; small molecule; social role; success; tool",Rational Design of Peptidomimetics Targeting Glucagon-Like Peptide-1 Receptors,"Peptides and proteins play fundamental roles in regulating critical biochemical pathways and often use helical  structures to exert their functions. This recognizes that small molecules which can accurately represent  helical structures would be of great value in modulating activity of target proteins, developing molecular tools to  probe their relevance in human diseases, and ultimately discovering novel therapeutic candidates. Herein,  we propose a rational approach to design and synthesize surrogates for a peptide hormone, glucagon-like  peptide-1 that plays important physiological roles in glucose homeostasis and treating diabetes.",80128,SBCB,Synthetic and Biological Chemistry B Study Section,A1,1,229500,
8002380,R56,DK,1,Y,02/01/2010,01/31/2011,PA-07-070,1R56DK083474-01A1,,NIDDK:220002;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MINNEAPOLIS,UNITED STATES,BIOCHEMISTRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"KIM, DO-HYUNG ;",8068371;,1R56DK083474,02/01/2010,01/31/2011,"ATP-protein phosphotransferase; Address; Adipocytes; Adipose Cell; Adipose tissue; Aging; Autophagocytosis; Biology; Body Tissues; Cancers; Cell Function; Cell Process; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Collaborations; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; EC 2.7; Energy Expenditure; Energy Metabolism; Eukaryote; Eukaryotic Cell; Fat Cells; Fatty Tissue; GeneHomolog; Genes; Goals; Homolog; Homologous Gene; Homologue; Infection; Insulin Resistance; Intermediary Metabolism; Investigators; Kinases; Knowledge; Laboratories; Link; Lipocytes; METBL; MODY; Malignant Neoplasms; Malignant Tumor; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mechanics; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mitochondria; Molecular; NIDDM; Nerve Degeneration; Neuron Degeneration; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Organelles; Phosphorylation; Phosphotransferases; Physiology; Play; Protein Kinase; Protein Phosphorylation; Proteins; RAFT-1 gene product; Rapamune; Rapamycin; Regulation; Research; Research Personnel; Researchers; Role; Senescence; Sirolimus; Starvation; Stress; Subcellular Process; T2D; T2DM; Thesaurismosis; Tissues; Transphosphorylases; Type 2 diabetes; Type II diabetes; Yeasts; adipose; adiposity; adult onset diabetes; autophagy; cell growth; corpulence; corpulency; corpulentia; diabetes; endoplasmic reticulum stress; eukaryotida; fat metabolism; gene product; glycogen synthase a kinase; human disease; hydroxyalkyl protein kinase; insulin resistant; insulin sensitivity; ketosis resistant diabetes; lipid metabolism; mTOR gene product; mTOR protein; macromolecule; malignancy; mammalian target of rapamycin (mTOR); maturity onset diabetes; metabolism disorder; microbial; mitochondrial; mitochondrial dysfunction; neoplasm/cancer; neural degeneration; neurodegeneration; neuronal degeneration; obese; obese people; obese person; obese population; phosphorylase b kinase kinase; protein complex; response; senescent; social role; white adipose tissue; yellow adipose tissue",Role of Adipose Autophagy in Metabolism,"Insulin resistance in fat cells, which is commonly found in obese people, can cause problems with lipid  metabolism and often leads to type 2 diabetes. The mechanism underlying the development of insulin  resistance is not completely understood. This proposed research is intended to define a potential mechanism  involving autophagy, a nutrient-regulated cellular process through which dysfunctional organelles (especially  mitochondria) and proteins are degraded, that operates in fat cells and likely plays crucial roles in determining  insulin sensitivity of fat cells.",83474,CADO,Cellular Aspects of Diabetes and Obesity Study Section,A1,1,220002,
8002414,R56,DK,1,Y,01/15/2010,12/31/2010,PA-07-070,1R56DK085121-01,,NIDDK:239125;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"HUA, XIANXIN ;",8150048;,1R56DK085121,01/15/2010,12/31/2010,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; Abscission; Acute; Adenovirus E1A-Associated Protein p60; Affect; Americas; Arginine; Arginine, L-Isomer; B9 endocrine pancreas; Benign; Beta Cell; Blood Glucose; Blood Sugar; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cellular Proliferation; Cyclin A; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Gestational; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes, Gestational; Diabetes, Pregnancy-Induced; Diabetic mouse; Diagnosis; Diet; Drugs; E1A p60; Endocrine Glands; Endocrine Organs; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Excision; Extensive Disease; Extirpation; Fats; Fatty acid glycerol esters; Fear; Fright; GLP-1; Gene Transcription; Generalized Disease; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Gestational Diabetes; Glucose Intolerance; Goals; Histones; Humulin R; Hyperglycemia; Hyperplasia; Hyperplastic; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; L-Arginine; Link; Liver; MEA Type 1; MEA Type I; MEN Type 1; MEN Type I; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Medication; Menin; Mice; Multiple Endocrine Adenomatosis Type 1; Multiple Endocrine Adenomatosis, Type I; Multiple Endocrine Neoplasia Type 1; Multiple Endocrine Neoplasia Type I; Murine; Mus; Mutation; NIDDM; Natural regeneration; Neoplasms, Multiple Endocrine Type 1; Neoplasms, Multiple Endocrine Type I; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nuclear Protein; Nuclear Proteins; Organ; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Production; RNA Expression; Regeneration; Regulation; Removal; Research; Resistance; STZ; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Streptozocin; Streptozotocin; Surgical Removal; T2D; T2DM; Transcription; Transcription, Genetic; Type 2 diabetes; Type II diabetes; United States; Wermer Syndrome; Widespread Disease; Zanosar; adult onset diabetes; base; beta cell development; biological signal transduction; body system, hepatic; diabetes; diabetes of pregnancy; drug/agent; endocrine pancreas; endocrine pancreas development; feeding; genome mutation; glucagon-like peptide 1; hyperglycemic; islet development; islet progenitor; ketosis resistant diabetes; maturity onset diabetes; mouse model of diabetes; next generation; novel; organ system, hepatic; p60 (cyclin A); pathway; prevent; preventing; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; regenerate; resection; resistant; tumorigenic",Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.,"There are over 20 million patients with diagnosed or undiagnosed type 2 diabetes in the United States of  America; in these patients there is an inadequate number of beta cells to control blood glucose. Our proposed  studies likely unravel a new pathway, the menin pathway, in controlling beta cell proliferation, and this pathway  could be modulated to ameliorate type 2 diabetes. These studies will likely pave the way to develop the next  generation of new drugs to treat this widespread disease.",85121,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,1,239125,
7818919,RC1,AI,1,Y,01/15/2010,12/31/2011,OD-09-003,1RC1AI086238-01,,OD:978822;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"SPANGRUDE, GERALD J;",1886740;,1RC1AI086238,01/15/2010,12/31/2011,"Address; Allografting; Antirejection Therapy; Area; Autoimmune Diseases; Basic Research; Basic Science; Blood Cells; Blood, Cord; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Cell Differentiation; Cell Differentiation process; Cell Lineage; Cell Maturation; Cells; Chemicals; Class II Antigens; Class II Major Histocompatibility Antigens; Clinical; Clinical, Transplantation, Organ; DNA Recombination; DNA recombination (naturally occurring); Data; Development; Disease; Disorder; Dose; ES cell; Engineering; Engineerings; FLR; Failure (biologic function); Future; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Genetic Recombination; Graft Material; Graft Rejection; Grafting Procedure; Histocompatibility; Histocompatibility Antigens; Histocompatibility Antigens Class II; Human; Human Engineering; Human, General; I-A Antigen; Ia Antigens; Ia-Like Antigens; Immune; Immune Function, Cellular; Immune Response Antigens; Immune response; Immune system; Immune-Response-Associated Antigens; Immunization; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunodeficient Mouse; Immunologic Deficiency Syndromes; Immunologic Stimulation; Immunological Deficiency Syndromes; Immunological Stimulation; Immunostimulation; Immunosuppressive Therapy; Laboratories; Lead; Lymphocyte; Lymphocytic; MHC Class II; MHC Class II Genes; MHC Class II Molecule; MHC Class II Protein; MHC Receptor; MHC class II antigen; Major Histocompatibility Complex Class II; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature T-Cell; Mature T-Lymphocyte; Methods; Mice; Modeling; Monitor; Monozygotic twins; Mother Cells; Murine; Mus; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Pb element; Peripheral Blood Cell; Phase; Process; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Receptors, Antigen, T-Cell; Recombination; Recombination, Genetic; Research; Reticuloendothelial System, Bone Marrow; Sensitization, Immunologic; Sensitization, Immunological; Source; Specificity; Staging; Stem cells; Stromal Cells; System; System, LOINC Axis 4; T Cell Specificity; T-Cell Activation; T-Cell Development; T-Cell Immunologic Specificity; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; Technology; Testing; Therapeutic immunosuppression; Therapy, Anti-Rejection; Thymus-Dependent Lymphocytes; Tissue Compatibility; Tissue Engineering; Tissue Transplantation; Tissues; Toxic effect; Toxicities; Translating; Translatings; Transplant Rejection; Transplantation; Transplantation Antigens; Transplantation Rejection; Transplantation Surgery; Transplanted tissue; Twins, Identical; Umbilical Cord Blood; artificial immunosuppression; autoimmune disorder; base; body system, allergic/immunologic; cell engineering; cellular engineering; clinical applicability; clinical application; disease/disorder; embryonic stem cell; engineered tissue; failure; fetal cord blood; gene product; hESC; heavy metal Pb; heavy metal lead; host response; human ES cell; human ESC; human disease; human embryonic stem cell; hypoimmunity; immune deficiency disorder; immune function; immunodeficiency; immunoresponse; immunosuppression; language translation; lymph cell; model development; mouse model; neoplastic; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; progenitor; programs; public health relevance; receptor expression; regenerate new tissue; regenerating damaged tissue; response; scaffold; scaffolding; stem; stem cell of embryonic origin; thymocyte; thymus derived lymphocyte; tissue regeneration; transplant; tumor",Maturation of Human Lymphocytes for Transplantation," Project Narrative One of the major obstacles facing the field of tissue engineering is the problem of immune responses against transplanted tissues. This project proposes to define culture conditions that allow engineering of the human immune response to provide normal immune function in the absence of tissue rejection. The proposal will test the ability of human bone marrow, cord blood, and embryonic stem cells to develop into T lymphocytes with normal immune function but lacking reactivity against transplanted tissue.",86238,ZRG1,Special Emphasis Panel,,1,978822,
7808940,RC1,AR,1,Y,01/15/2010,01/14/2012,OD-09-003,1RC1AR058118-01,,OD:999659;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,MINNEAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"PERLINGEIRO, RITA C. R.;",8305613;,1RC1AR058118,01/15/2010,01/14/2012,"21+ years old; Adult; Autograft; Autologous Transplantation; Autotransplant; Cells; Clinic; Degenerative Disorder; Derivation; Derivation procedure; Disease; Disorder; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; ES cell; Ellis-van Creveld (EvC) syndrome; Embryo; Embryonic; Engraftment; Ethical Issues; Fibroblasts; Future; Generations; Goals; Homologous Transplantation; Human; Human, Adult; Human, General; In Vitro; Inbred mdx Mice; Injury; Issues, Ethical; Knowledge; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mice; Mice, Inbred mdx; Mother Cells; Mouse, mdx; Murine; Mus; Muscle; Muscle Fibers; Muscle Tissue; Muscle function; Muscle, Skeletal; Muscle, Voluntary; Muscular Dystrophies; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Myodystrophica; Myodystrophy; Myotubes; Natural regeneration; Paraxial Mesoderm; Patients; Progenitor Cells; Progressive Muscular Dystrophy, Duchenne Type; Pseudohypertrophic Muscular Dystrophy, Childhood; Regeneration; Rhabdomyocyte; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Stem cells; Testing; Therapeutic; Translating; Translatings; Transplantation; Transplantation, Allogeneic; Transplantation, Autologous; Transplantation, Homologous; Wild Type Mouse; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; adult human (21+); benign X-linked recessive muscular dystrophy; c myc; c-myc Genes; cell type; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; degenerative condition; degenerative disease; disease/disorder; embryonic stem cell; hESC; human ES cell; human ESC; human embryonic stem cell; improved; in vivo; induced pluripotent stem cell; injured; language translation; mild X-linked recessive muscular dystrophy; novel; progenitor; progressive muscular dystrophy of childhood; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; public health relevance; regenerate; regenerative; skeletal; stem; stem cell of embryonic origin; transplant; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",Examining the Therapeutic Potential of iPS cells in Duchenne Muscular Dystrophy," Project Narrative Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells hold great promise for the treatment of degenerative diseases, however to date studies on their potential use in the treatment of muscular dystrophies have been hampered by the difficulty of differentiating ES cells into skeletal muscle progenitors. This application builds on a novel method we have developed to generate muscle progenitors from mouse ES cells. We have shown that such progenitors can be transplanted into normal injured, and dystrophic mice, where they contribute to muscle fiber regeneration, and improve muscle function after injury. In these studies, we will apply this approach to wild-type mouse iPS cells (Aim 1) as well as ex vivo genetically corrected dystrophic mouse iPS cells (Aim 2), thus assessing proof-of-principle to whether these cells are endowed with in vivo regenerative potential. In Aim 3, we will investigate the mechanisms controlling muscle differentiation in human ES cells with the goal to apply this knowledge to future studies involving human iPS cells obtained from patients with Duchenne muscular dystrophy.",58118,ZRG1,Special Emphasis Panel,,1,999659,
7826465,RC1,DA,1,Y,01/15/2010,12/31/2010,OD-09-003,1RC1DA028446-01,,NIDA:499999;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,15,790622591,US,NY,100176706,NATIONAL CENTER ON ADDICTION/SUB ABUSE,"MORGENSTERN, JON ;",1882177;,1RC1DA028446,01/15/2010,12/31/2010,"Accountability; Active Follow-up; Address; American; Area; Asthma; Behavioral; Biology; Bronchial Asthma; Care, Health; Caring; Chronic; Chronic Disease; Chronic Illness; Clinical; Complex; Consensus; Criminal Justice; Development; Diabetes Mellitus; Disease; Disorder; Drug abuse; Drugs; Event; Freedom; Funding; Goals; Government; Grant; Health; Health system; Healthcare; Intervention; Intervention Strategies; Justice, Criminal; Knowledge; Laboratories; Liberty; Local Government; Medical Specialities; Medication; Medicine; Modeling; Nanoscale Science; Nanotechnology; Nature; Neurosciences; New York; PROV; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Population; Pressure; Pressure- physical agent; Process; Provider; Public Sector; QOC; Quality of Care; Recommendation; Regulation; Reporting; Science; Science of Medicine; Scientist; Services; Solutions; Specialties, Medical; Specialty; Substance Use Disorder; Substance abuse problem; System; System, LOINC Axis 4; Testing; Time; Translating; Translatings; Treatment Cost; Work; abuse of drugs; abuse of substances; abuses drugs; addiction; base; behavioral health; care systems; chronic care model; chronic disease/disorder; chronic disorder; comparative effectiveness; cost; cost effective; criminal offender; design; designing; diabetes; disease/disorder; drug/agent; effective intervention; effectiveness research; experiment; experimental research; experimental study; follow-up; implementation science; improved; innovate; innovation; innovative; interventional strategy; language translation; medical specialties; nano scale Science; nano tech; nano technology; nanotech; offender; pressure; research study; substance abuse; systems of care; tool",Treating Addiction as a Chronic Illness,"Project Narrative Substance Use Disorders (SUD) are among the most prevalent and costly health conditions in the U.S. Experts agree that the quality of care for SUD is mediocre. This proposal will capitalize on a unique set of policy events occurring in New York State to jump start a science-based, systems-level transform of the SUD care system and in the process create a national model for state-level interventions to improve the quality of care and reduce costs associated with SUD.",28446,ZRG1,Special Emphasis Panel,,1,499999,
7855323,RC2,EY,1,Y,02/01/2010,01/31/2011,OD-09-004,1RC2EY020678-01,,NEI:2213935;,2010,NATIONAL EYE INSTITUTE,,LA JOLLA,UNITED STATES,ZOOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GAASTERLAND, THERESA ;",6473600;,1RC2EY020678,02/01/2010,01/31/2011,"Affect; Age; Algorithms; American; Area; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Blindness; CNP; Code; Coding System; Complement; Complement Proteins; Computer Analysis; Copy Number Polymorphism; DNA; DNA Resequencing; DNA Sequence Rearrangement; Data; Deoxyribonucleic Acid; Development; Disease; Disease Association; Disease Management; Disease Progression; Disorder; Disorder Management; Ear; Ear structure; Early Diagnosis; Exons; Eye; Eye diseases; Eyeball; First Degree Relative; Funding; GWAS; Gene Targeting; Gene variant; General Population; General Public; Genes; Genetic; Genetic Diversity; Genetic Variation; Genome; Genome, Human; Genomics; Genotype; Glaucoma; Glean; Goals; Grouping; Health Benefit; Heritability; Human Genome; Intervening Sequences; Introns; Knowledge; Laboratories; Libraries; Life Style; Lifestyle; Maps; Massachusetts; Measures; Medical; Methods; Monozygotic Twinning; Monozygotic twins; Nature; ORFs; Open Reading Frames; POAG; Partial Sight; Pathogenesis; Pathway interactions; Patients; Point Mutation; Predisposition; Prevention; Primary Open Angle Glaucoma; Protein Coding Region; Proteins; Public Health; Rare Diseases; Rare Disorder; Reaction; Rearrangement; Records; Research; Resequencing; Risk; Role; SEQ-AN; Sampling; Sequence Analyses; Sequence Analysis; Structure; Susceptibility; Targetings, Gene; Technology; Testing; Time; Tube; Twins, Identical; United States; Variant; Variation; Variation (Genetics); Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual impairment; Work; allelic variant; base; case control; comparative; computational analysis; copy number variation; design; designing; disease/disorder; early detection; exome; eye center; eye disorder; gene product; genetic variant; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; glaucomatous; groupings; human disease; improved; innovate; innovation; innovative; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; member; novel; ophthalmopathy; pathway; prevent; preventing; public health medicine (field); public health relevance; social role; visually impaired; whole genome association studies; whole genome association study",Genome-Wide Targeted Gene Resequencing in Glaucoma,"Project Narrative Primary open angle glaucoma (POAG) is the most common form of glaucoma in the United States and a leading cause of irreversible blindness and visual impairment worldwide, affecting more than 2 million Americans over age 40, and causing blindness in ~100,000 Americans and 3 million people worldwide each year. Treatments for the disease can slow progression but do not reverse damage, so early detection is the key for effective disease management and prevention of further damage; so to find genomic variations associated with POAG, a disease with high heritability and with no remedial treatment, this research will use a novel dual approach to genome-wide association study: re-sequence all exons from protein-coding genes in 350 cases and 350 controls, and simultaneously, study copy number variation to find disease-associated single point mutations, small insertions and deletions, and genome structure variations. This research could have considerable public health benefit by identifying genes and their variants associated with pathogenesis of the disease, leading to new strategies for early diagnosis and treatment, inhibition of vision loss, and possibly provide an avenue to prevention.",20678,ZHG1,Special Emphasis Panel,,1,2213935,
7792771,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR023594-01A1,,NCRR:194240;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"DIFIGLIA, MARIAN ;",1875161;,1S10RR023594,02/01/2010,01/31/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Disease Models; Area; Autophagocytosis; Cell Membrane Permeability; Communities; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Demyelinations; Disease; Disorder; Electron Microscope; Electron Microscopy; General Hospitals; Hospitals, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Institution; Investigators; Lewy Body Parkinson Disease; Massachusetts; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neurology; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Primary Parkinsonism; Primary Senile Degenerative Dementia; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Receptors, Neurohumor; Records; Recycling; Research; Research Personnel; Researchers; Role; Training; Transmission; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Work; autophagy; computer imaging; dementia of the Alzheimer type; digital imaging; disease/disorder; gene product; improved; instrument; membrane permeability; neurodegenerative illness; neuronal; primary degenerative dementia; senile dementia of the Alzheimer type; social role; transmission process; traumatic brain damage",Request for electron microscope,,23594,ZRG1,Special Emphasis Panel,A1,1,194240,
7794221,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR023629-01A2,,NCRR:497680;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BUFFALO,UNITED STATES,,28,074025479,US,NY,14203,HAUPTMAN-WOODWARD MEDICAL RESEARCH INST,"LATTMAN, EATON E;",1880427;,1S10RR023629,01/28/2010,01/27/2011,"Anodes; Data Collection; Disease; Disorder; Drug Design; Drugs; Equipment; FLR; Failure (biologic function); Funding; Housing; Image; Institutes; Life; Medical Research; Medication; Organism; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Research Institute; Research, Medical; Robotics; Roentgen Rays; Saturn; Site; System; System, LOINC Axis 4; Time; Work; X-Radiation; X-Rays; Xrays; detector; disease/disorder; drug/agent; failure; gene product; imaging; living system",Acquisition of Rigaku MicroMax-007 HF lab x-ray system,,23629,ZRG1,Special Emphasis Panel,A2,1,497680,
7794555,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR023651-01A2,,NCRR:495000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,WEST LAFAYETTE,UNITED STATES,OTHER BASIC SCIENCES,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"LEARY, JAMES F.;",1959200;,1S10RR023651,01/07/2010,01/06/2011,"Ablation; Abscission; Area; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Cell Culture Techniques; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Contracting Opportunities; Contracts; Cytofluorometry, Flow; Cytometry; Electromagnetic, Laser; Electroporation; Evolution; Excision; Extirpation; Far Go; FarGo; Fees; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Funding; Future; Gene Expression Microarray Analysis; Generalized Growth; Genes; Grant; Graphical interface; Growth; Injection of therapeutic agent; Injections; Instrumentation, Other; Laboratories; Lasers; Life; Maintenance; Maintenances; Manuals; Microfluorometry, Flow; Minor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Process; Proteomics; Radiation, Laser; Removal; Research; Running; Sampling; Scanning; Site; Sorting - Cell Movement; Speed; Speed (motion); Surgical Removal; Suspension substance; Suspensions; System; System, LOINC Axis 4; Testing; Tissue Growth; Training; United States National Institutes of Health; Universities; Vendor; Visit; base; cell imaging; cell sorting; cellular imaging; cost; experience; flow cytophotometry; graphic user interface; graphical user interface; image processing; instrument; instrumentation; macromolecule; ontogeny; prototype; resection; software systems; sorting; suspension",LEAP Image Scanning Cytometer/Sorter/Optoinjection Shared Instrument,,23651,ZRG1,Special Emphasis Panel,A2,1,495000,
7794699,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR025554-01A1,,NCRR:500000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BRONX,UNITED STATES,PATHOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"SANTAMBROGIO, LAURA ;",2295855;,1S10RR025554,02/01/2010,01/31/2011,"Appearance; Artifacts; Arts; Au element; Bacteria; Biogenesis; Biological; Cell Locomotion; Cell Migration; Cell Movement; Cell secretion; Cell surface; Cellular Migration; Cellular Secretion; Characteristics; Cytoplasmic Granules; Dehydration; Devices; Electron Microscope; Electron Microscopy; Electrons; Freezing; Funding; Gold; Image; Investigation; Investigators; Location; Lysosomes; Microscopy, Electron, Scanning; Microscopy, Electron, Scanning Transmission; Modification; Morphologic artifacts; Morphology; Motility; Motility, Cellular; Negative Beta Particle; Negatrons; Nematoda; Nematodes; Organelles; Origin of Life; Physiologic; Physiological; Receptor Protein; Research Personnel; Research Resources; Researchers; Resolution; Resources; Sampling; Scanning; Scanning Transmission Electron Microscopy Procedures; Source; Structure; Surface; System; System, LOINC Axis 4; Time; Training of Investigators; V (voltage); body water dehydration; cell imaging; cell motility; cellular imaging; fungus; granule; imaging; investigator training; late endosome; pathogen; receptor; roundworm; voltage",Field Emission Scanning Electron Microscope for use in a multi-user Facility,,25554,ZRG1,Special Emphasis Panel,A1,1,500000,
7784169,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR026293-01,,NCRR:200000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,IOWA CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"WEISS, ROBERT M;",1916313;,1S10RR026293,01/28/2010,01/27/2011,"Animals; Architecture; Archives; Cancers; Cardiac; Cardiac Valves; Cardiomyopathies; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Charge; Clinical; Color; Computer Hardware; Computer Programs; Computer software; Contract Services; Data; Diagnosis, Ultrasound; Disease; Disease model; Disorder; Disorder of muscle, unspecified; Doppler velocimetry; Drugs, Nonproprietary; Echography; Echotomography; Engineering / Architecture; Equipment; Event; FLR; Failure (biologic function); Funding; Funding Applicant; Future; Generic Drugs; Genetic; Gestosis, EPH; Heart Valves; Hereditary; Housing; Human; Human Resources; Human, General; Image; Image Analyses; Image Analysis; Imagery; Inherited; Iowa; Lead; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manpower; Medical Imaging, Ultrasound; Mice; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organ System, Cardiovascular; Pb element; Phenotype; Physiologic; Physiological; Pre-Eclampsia; Preeclampsia; Proteinuria-Edema-Hypertension Gestosis; ROC Analysis; Research; Resolution; Rodent; Rodentia; Rodentias; Salaries; Services; Software; Structure; System; System, LOINC Axis 4; Toxemias, Pregnancy; Trust; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States National Institutes of Health; Universities; Vascular, Heart; Vendor; Visualization; Wages; cardiovascular function; circulatory system; clinical relevance; clinically relevant; computer program/software; computer system hardware; cost; design; designing; diagnostic ultrasound; disease/disorder; disorder model; failure; fetal; generic; heavy metal Pb; heavy metal lead; human disease; image evaluation; imaging; improved; instrument; interest; malignancy; meetings; muscular disorder; myocardium disorder; neoplasm/cancer; open source; personnel; pregnancy toxemia/hypertension; public health relevance; sonogram; sonography; sound measurement; ultrasound; ultrasound imaging; ultrasound scanning; waiver",Research Ultrasound Imaging Upgrades,,26293,ZRG1,Special Emphasis Panel,,1,200000,
7791805,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR026405-01,,NCRR:359897;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,ANN ARBOR,UNITED STATES,UROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"KELLER, EVAN TODD;",1883659;,1S10RR026405,02/01/2010,01/31/2011,"Advisory Committees; Animals; Award; Biology of Aging; Bioluminescence; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Bp50; CD40; CDW40; Cancer Center; Cancers; Cells; Commit; Dental Schools; Disease; Disorder; Ensure; Equipment; Evaluation; Fluorescence; Funding; Generalized Growth; Goals; Growth; Health; Image; Imagery; In Vitro; Investigators; K22 Award; Label; Life; Location; MGC9013; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Medical; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Michigan; Monitor; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neoplasm Metastasis; R01 Mechanism; R01 Program; RPG; Reporter; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Scanning; Schools, Dental; Secondary Neoplasm; Secondary Tumor; Source; System; System, LOINC Axis 4; TNFRSF5; TNFRSF5 gene; Task Forces; Technology; Time; Tissue Growth; Tissues; Training; Transmission; Tumor Cell Migration; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; United States National Institutes of Health; Universities; Visualization; Walking; age dependent; age related; angiogenesis; angiogenesis therapy; animal facility; base; bone; cancer metastasis; cost; design; designing; disease/disorder; efficacy testing; experience; experiment; experimental research; experimental study; imaging; improved; in vivo; malignancy; member; molecular imaging; neoplasm/cancer; ontogeny; p50; public health relevance; research study; therapeutic angiogenesis; transmission process",In vivo non-invasive 3D quantitative IVIS Spectrum molecular imaging system,,26405,ZRG1,Special Emphasis Panel,,1,359897,
7791622,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR026429-01,,NCRR:495988;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,MINNEAPOLIS,UNITED STATES,DENTISTRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"ZHANG, WEI ;",9243662;,1S10RR026429,01/07/2010,01/06/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 27E10 Antigen; AIDS Virus; Adhesins, Bacterial; Alpha Virus; Alphavirus; Animal Viruses; Antiviral Agents; Antiviral Drugs; Antivirals; Applications Grants; Arboviruses, Group A; Bacillus subtilis; Bacterial Adhesins; Bacteriophages; Biologic Sciences; Biological Sciences; Calcium-Binding Myeloid Protein P8,14; Calgranulin; Calprotectin; Cilia; Diabetes Mellitus; Disease; Disorder; Electron Microscope; Electron Microscopy; Faculty; Flagella; Grant Proposals; Grants, Applications; HIV-1; HIV-I; HIV1; Health; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Institutes; Instrumentation, Other; Investigators; Kidney; L1 Antigen; Leukocyte L1 Antigen Complex; Leukocyte L1 Protein; Life Sciences; Macromolecular Structure; Macropain; Macroxyproteinase; Membrane Fusion; Microbial Biofilms; Migratory Inhibitory Factor-Related Protein MRP; Minnesota; Modeling; Molecular Structure; Molecular Virology; Multicatalytic Proteinase; Myelomonocytic Antigen L1; Patients; Phages; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteosome; Research; Research Personnel; Researchers; School Dentistries; School Dentistry; Schools, Medical; Sensory; Structure; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; Transmission; Universities; Urinary System, Kidney; Variant; Variation; Viruses, Animal; adhesin; bacterial virus; biofilm; commensal bacteria; commensal microbes; diabetes; disease/disorder; human T cell leukemia virus III; human T lymphotropic virus III; instrument; instrumentation; keratinocyte; medical schools; member; microbial; multicatalytic endopeptidase complex; particle; renal; structural biology; thymus derived lymphocyte; transmission process",Transmission Electron Microscope in the Academic Health Center,,26429,ZRG1,Special Emphasis Panel,,1,495988,
7791902,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR026501-01,,NCRR:477916;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,ROCHESTER,UNITED STATES,BIOCHEMISTRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"WEDEKIND, JOSEPH E;",1927484;,1S10RR026501,02/01/2010,01/31/2011,"14 year old; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Area; Arts; Biological; Biology; Cells; Clinical; Contract Services; Core Facility; Cost Sharing; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Development; Doctor of Philosophy; Equipment; FLR; Failure (biologic function); Fees; Funding; Gene Products, RNA; Genome; Goals; Hand; Head; High Throughput Assay; Housing; Immunologic Deficiency Syndrome, Acquired; Institutes; Instrumentation, Other; Investigators; Maintenance; Maintenances; Medical center; Medicine; Methods and Techniques; Methods, Other; Mission; Optics; Ph.D.; PhD; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RNA; RNA, Non-Polyadenylated; RPG; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Resource Sharing; Ribonucleic Acid; Roentgen Rays; Salaries; Sampling; Science of Medicine; Scientist; Screening procedure; Services; Single Crystal Diffraction; Source; Specialist; Staging; Stream; System; System, LOINC Axis 4; Targeted Research; Techniques; Technology; Testing; Tube; Universities; Wages; War; X Ray Crystallographies; X ray diffraction; X ray diffraction analysis; X-Radiation; X-Ray Crystallography; X-Ray Diffraction; X-Rays; Xray Diffraction; Xrays; aged; detector; experiment; experimental research; experimental study; failure; fourteen year old; high throughput screening; human disease; improved; instrument; instrumentation; programs; public health medicine (field); research study; screening; screenings; seal",A shared macromolecular X-ray diffraction system in Rochester,,26501,ZRG1,Special Emphasis Panel,,1,477916,
7790922,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR026503-01,,NCRR:496719;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,PITTSBURGH,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"KIM, SEONG-GI ;",1979618;,1S10RR026503,01/28/2010,01/27/2011,"Animals; Arts; Biomedical Research; Bite; Cell Nucleus; Computer Programs; Computer software; Equipment; Frequencies (time pattern); Frequency; Funding; Future; Grant; H+ element; Hydrogen Ions; Image; Imaging Device; Imaging Tool; Instrumentation, Other; Investigators; Libraries; Linux; Magnetic Resonance; NCRR; National Center for Research Resources; Nucleus; Operating System; Personal Computers; Physiologic; Physiologic pulse; Physiological; Protons; Pulse; Research; Research Personnel; Researchers; Resolution; Sampling; Software; System; System, LOINC Axis 4; The Sun; Universities; analog; base; bioimaging; bioimaging/biomedical imaging; biomedical imaging; computer program/software; digital; imaging; in vivo; instrument; instrumentation; microsystems; pre-clinical; preclinical; public health relevance",9.4T MR Instrument Console Upgrade,,26503,ZRG1,Special Emphasis Panel,,1,496719,
7791458,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR026525-01,,NCRR:115000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SEATTLE,UNITED STATES,BIOMEDICAL ENGINEERING,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"CASTNER, DAVID G;",1995232;,1S10RR026525,01/07/2010,01/06/2011,"3-D; 3-D Imaging; 3-Dimensional; 3D image; 3D imaging; Antibodies; Biocompatible Materials; Biological; Biological Function; Biological Process; Biomaterials; Biosensor; Body Tissues; Carbohydrates; Cells; Chemicals; Communities; Devices; Drugs; Electrons; Funding; Image; Images, 3-D; Imaging, Three-Dimensional; Ions; Knowledge; Macromolecular Structure; Manufacturer; Manufacturer Name; Medical Imaging, Three Dimensional; Medication; Methods and Techniques; Methods, Other; Microbial Biofilms; Molecular; Molecular Structure; Negative Beta Particle; Negatrons; Pharmaceutic Preparations; Pharmaceutical Preparations; R01 Mechanism; R01 Program; RPG; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; SIMS Microscopy; Sampling; Secondary Ion Mass Spectrometry Microscopy; Secondary Ion Mass Spectroscopy Microscopy; Source; Spectrometry, Mass, Secondary Ion; Spectroscopy; Spectroscopy, Mass, Secondary Ion; Spectrum Analyses; Spectrum Analysis; Stents; Surface; Surface Properties; Techniques; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissue Engineering; Tissues; Universities; Washington; biofilm; biomedical implant; design; designing; drug/agent; engineered tissue; experience; falls; imaging; implant device; implantable device; improved; indwelling device; instrument; ion source; medical implant; scaffold; scaffolding; sensor (biological); success",Cluster Ion Source for ESCA Instrument,,26525,ZRG1,Special Emphasis Panel,,1,115000,
7791590,S10,RR,1,Y,01/26/2010,01/25/2011,PAR-09-028,1S10RR026526-01,,NCRR:455000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SHLOMCHIK, MARK J;",1935323;,1S10RR026526,01/26/2010,01/25/2011,"Accounting; Ally; Area; Biology; Blood Vessels; Cancer stem cell; Caring; Cells; Cellular biology; Communicable Diseases; Cytofluorometry, Flow; Detection; Dimensions; Direct Costs; Discipline; Electromagnetic, Laser; Ensure; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Funding; Hand; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Hour; Image; Image Analyses; Image Analysis; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunologic Diseases; Immunological Diseases; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infrastructure; Institutes; Investigators; Lasers; Microfluorometry, Flow; Minor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Phase; Principal Investigator; Productivity; ROC Analysis; Radiation, Laser; Research; Research Infrastructure; Research Personnel; Researchers; Services; Stem Cell Research; Stream; Time; Training; United States National Institutes of Health; Work; cell biology; experiment; experimental research; experimental study; flow cytophotometry; image evaluation; imaging; instrument; new approaches; novel approaches; novel strategies; novel strategy; optic imaging; optical imaging; public health relevance; research study; stem cell biology; vascular",Amnis ImageStream Analyzer for the Yale Flow Core,,26526,ZRG1,Special Emphasis Panel,,1,455000,
7794638,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR026719-01,,NCRR:459995;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NASHVILLE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"REYNOLDS, ALBERT B;",6936036;,1S10RR026719,02/01/2010,01/31/2011,"Academic Medical Centers; Area; Biology; Cancer Center; Cancer of the Gastrointestinal Tract; Cancers; Cell Line; Cell Lines, Strains; CellLine; Chemicals; Community Healthcare; Core Facility; Country; Detection; Diagnosis; Explosion; Funding; Gastrointestinal Cancer; Hand; Health; Health Care Research; Health Care, Community; Health Services Evaluation; Health Services Research; Healthcare Research; Healthcares, Community; Housing; Hybridomas; Individual; Institutes; Malignant Gastrointestinal Neoplasm; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of gastrointestinal tract; Mass Spectrum; Mass Spectrum Analysis; Medical Care Research; Mission; Moab, Clinical Treatment; Monoclonal Antibodies; Mouse Models of Human Cancer Consortium; NIH; NIH RFA; National Institutes of Health; National Institutes of Health (U.S.); Photometry/Spectrum Analysis, Mass; Process; Productivity; Programs (PT); Programs [Publication Type]; Proteomics; Reagent; Reproduction spores; Request for Applications; Research; Resource Sharing; Role; Screening procedure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spores; System; System, LOINC Axis 4; Time; United States National Institutes of Health; University Medical Centers; Vaccines; Work; anticancer research; cancer research; clinical applicability; clinical application; cultured cell line; instrument; malignancy; meetings; neoplasm/cancer; programs; public health relevance; screening; screenings; services research; social role; success; therapeutic target; tool",Acquistion of a ClonePix FL System,,26719,ZRG1,Special Emphasis Panel,,1,459995,
7791815,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR026780-01,,NCRR:411627;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,STANFORD,UNITED STATES,ANATOMY/CELL BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"TALBOT, WILLIAM S;",1905329;,1S10RR026780,01/28/2010,01/27/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Model; Animal Models and Related Studies; Area; Arvin; Arwin; Axon; Bacterial Chromosomes; Berk Brand of Ancrod; Biological; Biology; CCD camera; Cancers; Cell Polarity; Cells; Cellular Matrix; Chromosomes, Bacterial; Communities; Complex; Cytoskeletal System; Cytoskeleton; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Electron Microscope; Electron Microscopy; Electron Microscopy Facility; Funding; Health; Human; Human, General; Image; Intracellular Structure; Knoll Brand of Ancrod; Light; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Micro-tubule; Microtubules; Modeling; Molecular; NIH; NIH RFA; National Institutes of Health; National Institutes of Health (U.S.); Nematoda; Nematodes; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Pathway interactions; Photoradiation; Primary Senile Degenerative Dementia; R01 Mechanism; R01 Program; RPG; Receptor Protein; Regulation; Request for Applications; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Resource Sharing; Sampling; Science; Sensory; Subcellular structure; Touch; Touch sensation; Transmission; United States National Institutes of Health; Universities; Viral; Viral Pathogenesis; Wound Healing; Wound Repair; Yeasts; amyloid assembly; amyloid formation; base; cellular polarity; charge coupled device camera; computer imaging; dementia of the Alzheimer type; digital imaging; disease/disorder; experience; human tissue; imaging; instrument; intracellular skeleton; malignancy; member; migration; model organism; neoplasm/cancer; neuronal; pathway; primary degenerative dementia; receptor; response; roundworm; senile dementia of the Alzheimer type; skin regeneration; tissue repair; transmission process",Transmission Electron Microscope,,26780,ZRG1,Special Emphasis Panel,,1,411627,
7793689,S10,RR,1,Y,01/26/2010,01/25/2011,PAR-09-028,1S10RR026802-01,,NCRR:499950;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SALT LAKE CITY,UNITED STATES,MISCELLANEOUS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"GREEN, WAYNE FRANCIS;",6218223;,1S10RR026802,01/26/2010,01/25/2011,"Address; Area; Arts; Bacteria; Brachydanio rerio; Cancer Immunology Science; Cancers; Care, Health; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Segregation; Cell Separation; Cell Separation Technology; CellLine; Cells; Cellular biology; Cherries; Cherry - dietary; Color; Compensation; Cytofluorometry, Flow; Danio rerio; Data; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Electromagnetic, Laser; FP593; Financial compensation; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorochrome; Funding; Genetic; Grant; Health; Health Sciences; Healthcare; Human; Human, General; Image; Institutes; Instrumentation, Other; Investigators; Lasers; Lymphatic Tissue; Lymphoid Tissue; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Manufacturer; Manufacturer Name; Medical; Medical center; Microfluorometry, Flow; NCRR; NIH; National Center for Research Resources; National Institutes of Health; National Institutes of Health (U.S.); Organelles; Peer Review; Pharmacy Schools; Population; Process; Public Health; Radiation, Laser; Reporter; Research; Research Personnel; Researchers; Resolution; Running; Sampling; Schools, Pharmacy; Services; Sorting - Cell Movement; Technology; Testing; Time; United States National Institutes of Health; Universities; Utah; Yeasts; Zebra Danio; Zebra Fish; Zebrafish; cancer immunology; cell biology; cell sorting; cultured cell line; drFP583; drug development; ds red protein; dsFP593; flow cytophotometry; imaging; instrument; instrumentation; malignancy; meetings; neoplasm/cancer; public health medicine (field); public health relevance; red fluorescent protein; sorting; success; tumor",Univ of Utah Cell Sorter for Flow Cytometry Core,,26802,ZRG1,Special Emphasis Panel,,1,499950,
7792508,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR026814-01,,NCRR:228059;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SAN FRANCISCO,UNITED STATES,BIOCHEMISTRY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"CHENG, YIFAN ;",8823289;,1S10RR026814,01/28/2010,01/27/2011,"Biomedical Research; Boxing; Complex; Complexes, Macromolecular; Computer Programs; Computer software; Computers; Cryo-electron Microscopy; Cryoelectron Microscopy; Data Set; Dataset; Electron Cryomicroscopy; Electron Microscope; Funding; Goals; Image; Linux; Macromolecular Complexes; NIH; National Institutes of Health; National Institutes of Health (U.S.); Process; Proteins; R01 Mechanism; R01 Program; RPG; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Software; Structure; System; System, LOINC Axis 4; United States National Institutes of Health; Virus; Viruses, General; computer program/software; computerized data processing; cryoEM; data processing; develop software; developing computer software; digital; experience; gene product; imaging; particle; protein complex; signal processing; software development; success",GPU Computing Enabled Linux Computer Cluster,,26814,ZRG1,Special Emphasis Panel,,1,228059,
7792823,S10,RR,1,Y,01/26/2010,01/25/2011,PAR-09-028,1S10RR026825-01,,NCRR:499785;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"NOLTA, JAN A.;",1865657;,1S10RR026825,01/26/2010,01/25/2011,"Area; Arts; Biology; Cancer Center; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Collaborations; Color; Core Facility; Custom; Cytofluorometry, Flow; Development; Electromagnetic, Laser; Ensure; Equipment; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorochrome; Funding; Future; Grant; Institutes; Instrumentation, Other; Investigators; Lasers; Location; Medical center; Microfluorometry, Flow; Mind; Mother Cells; NCI-Designated Cancer Center; NIH; National Institutes of Health; National Institutes of Health (U.S.); Optics; Progenitor Cells; Programs (PT); Programs [Publication Type]; Publications; Radiation, Laser; Research; Research Personnel; Researchers; Scientific Publication; Stem cells; Technology; United States National Institutes of Health; base; cell sorting; design; designing; flow cytophotometry; instrument; instrumentation; programs; stem cell biology; success; tool",Shared LSRII Cytometer Equipment Application - UC Davis Stem Cell Program,,26825,ZRG1,Special Emphasis Panel,,1,499785,
7794136,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR026881-01,,NCRR:463840;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"FISHMAN, GLENN I;",1902100;,1S10RR026881,02/01/2010,01/31/2011,"Animals; Area; Arts; Biological; Biological Function; Biological Models; Biological Process; Cancer Biology; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Development; Developmental Process; Diagnosis, Ultrasound; Disease; Disease Progression; Disorder; Echography; Echotomography; Equipment; Experimental Animal Model; Funding; Generations; Genetically Engineered Mouse; Health; Heart; Human Development; Image; Instrumentation, Other; Investigators; Knowledge; Life; Mammals, Mice; Measurement; Medical; Medical Imaging, Ultrasound; Mice; Mission; Model System; Modeling; Models, Biologic; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurologic; Neurological; Organ System, Cardiovascular; Organism; Pathologic; Programs (PT); Programs [Publication Type]; Research; Research Personnel; Researchers; Resolution; Schools, Medical; Staging; Structure; System; System, LOINC Axis 4; Time; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States National Institutes of Health; Vascular, Heart; bioimaging; bioimaging/biomedical imaging; biomedical imaging; circulatory system; diagnostic ultrasound; disease/disorder; imaging; imaging modality; improved; insight; instrumentation; living system; medical schools; programs; public health relevance; response; sonogram; sonography; sound measurement; tool; ultrasound; ultrasound imaging; ultrasound scanning",High Resolution Imaging System,,26881,ZRG1,Special Emphasis Panel,,1,463840,
7793214,S10,RR,1,Y,01/26/2010,01/25/2011,PAR-09-028,1S10RR026916-01,,NCRR:235750;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,HOUSTON,UNITED STATES,PEDIATRICS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"COOPER, LAURENCE J.N.;",1933174;,1S10RR026916,01/26/2010,01/25/2011,"Active immunity; Animals; Applications Grants; Assay; Bioassay; Biologic Assays; Biologic Therapy; Biological Assay; Biological Response Modifier Therapy; Biological Therapy; Body Tissues; Cancer Immunology Science; Cancers; Cells; Clinical; Cytofluorometry, Flow; Detection; Enzymes; Expression Profiling; Expression Signature; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Formalin; Gene Expression; Gene Expression Profile; Gene Products, RNA; Genes; Grant Proposals; Grants, Applications; Homing; Human; Human, General; IMPHENO; ITX; Image; Immune; Immunologically Directed Therapy; Immunophenotyping; Immunotherapeutic agent; Immunotherapy; Infusion; Infusion procedures; Institution; Investigators; MDACC; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measurement; Messenger RNA; Microfluorometry, Flow; Modern Medicine; Molecular; Molecular Fingerprinting; Molecular Profiling; Paraffin Embedding; Patients; Phenotype; Programs (PT); Programs [Publication Type]; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Reaction; Research; Research Personnel; Researchers; Ribonucleic Acid; Role; Sampling; Serologic; Serological; Specificity; Subtyping, Immunologic; Subtypings, Immunologic; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Technology; Testing; Therapeutic; Tissue Sample; Tissues; Transcript; University of Texas M D Anderson Cancer Center; University of Texas MD Anderson Cancer Center; WHBLOOD; Whole Blood; Work; base; biotherapeutics; biotherapy; cancer immunology; conventional therapy; design; designing; digital; flow cytophotometry; gene expression signature; imaging; immune therapy; immunologic preparation; immunophenotype; immunotherapeutics; improved; mRNA; mRNA Expression; malignancy; molecuar profile; molecular signature; neoplasm/cancer; new technology; next generation; novel; programs; protein expression; single molecule; social role; tissue/cell culture; transcriptome; tumor",nCounter Prep Station and the Digital Analyzer,,26916,ZRG1,Special Emphasis Panel,,1,235750,
7793271,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR026935-01,,NCRR:364688;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"DAVIS, RANDALL S;",2054478;,1S10RR026935,01/07/2010,01/06/2011,"Advisory Committees; Alabama; Area; Arts; Binding; Binding (Molecular Function); Biosensor; Commit; Communities; Complement; Complement Proteins; Conflict; Conflict (Psychology); Discipline; Ensure; Expertise, Technical; Fees; Funding; Generalized Growth; Grant; Growth; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Instrumentation, Other; Investigators; Kinetic; Kinetics; Laboratories; Leadership; Microbiology; Minor; Molecular Interaction; Operation; Operative Procedures; Operative Surgical Procedures; Research; Research Institute; Research Personnel; Research Resources; Researchers; Resources; Running; Salaries; Schools; Science of Microbiology; Scientist; Surface Plasmon Resonance; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Technical Expertise; Tissue Growth; Training; Translational Research; Translational Research Enterprise; Translational Science; Universities; Wages; base; cost; drug discovery; experience; innovate; innovation; innovative; instrument; instrumentation; interest; multidisciplinary; novel; ontogeny; sensor (biological); success; surgery; translation research enterprise",UAB Shared Biacore T100 Biosensor,,26935,ZRG1,Special Emphasis Panel,,1,364688,
7794706,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR027088-01,,NCRR:495100;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SAN FRANCISCO,UNITED STATES,SURGERY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"TANG, QIZHI ;",6065721;,1S10RR027088,02/01/2010,01/31/2011,"Aerosols; Animal Model; Animal Models and Related Studies; Applications Grants; Asthma; Bronchial Asthma; California; Cancer Immunology Science; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Clinical; Communities; Containment; Custom; Cytofluorometry, Flow; Development; Development and Research; Devices; Diabetes Mellitus; Electromagnetic, Laser; Ensure; Equipment; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Funding; Grant Proposals; Grants, Applications; Hour; Housing; Human; Human, General; Investigators; Laboratories; Laboratory Research; Lasers; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Microfluorometry, Flow; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Process; Programs (PT); Programs [Publication Type]; R & D; R&D; R01 Mechanism; R01 Program; RPG; Radiation, Laser; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Support; Research, Laboratory; Researchers; Safety; Sampling; San Francisco; Speed; Speed (motion); Transplantation; Tube; United States National Institutes of Health; Universities; advanced system; base; cancer immunology; career; cell sorting; design; designing; diabetes; experience; flexibility; flow cytophotometry; fluorescence activated cell sorter; fluorescence activated cell sorter device; improved; instrument; meetings; model organism; pathogen; photomultiplier; programs; public health relevance; research and development; response; transplant; user-friendly","""BD FACS ARIA II CELL SORTER'",,27088,ZRG1,Special Emphasis Panel,,1,495100,
7794649,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR027187-01,,NCRR:111200;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,COLUMBUS,UNITED STATES,BIOCHEMISTRY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"CHAN, MICHAEL K;",1925615;,1S10RR027187,01/07/2010,01/06/2011,"Address; Amino Acids; Area; Arts; Collaborations; Complex; Crystallization; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Culicidae; DNA Repair Enzymes; Drugs; Equipment; Faculty; Funding; Health; Housing; Human; Human, General; Investigators; Man (Taxonomy); Man, Modern; Medication; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Minor; Mosquitoes; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Ohio; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Programs (PT); Programs [Publication Type]; Proteins; RNA Metabolism[{..}] Processing and Transport; RNA Processing; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Regulation; Research; Research Personnel; Researchers; Robot; Roentgen Rays; Running; Sampling; Single Crystal Diffraction; Solutions; Structure; System; System, LOINC Axis 4; Techniques; Technology; Testing; United States National Institutes of Health; Universities; X Ray Crystallographies; X ray diffraction; X ray diffraction analysis; X-Radiation; X-Ray Crystallography; X-Ray Diffraction; X-Rays; Xray Diffraction; Xrays; aminoacid; college; design; designing; drug/agent; experiment; experimental research; experimental study; gene product; insight; instrument; interest; member; nano; novel; programs; protein function; protein structure; quorum sensing; research study; small molecule; success; tool",OSU Crystallography Facility: Acquisition of Crystallization Robot,,27187,ZRG1,Special Emphasis Panel,,1,111200,
7790426,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR027217-01,,NCRR:312504;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SEATTLE,UNITED STATES,BIOCHEMISTRY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"KLEVIT, RACHEL E.;",1883149;,1S10RR027217,01/07/2010,01/06/2011,"Arts; Basic Research; Basic Science; Cancers; Collaborations; Communicable Diseases; Data; Disease; Disorder; Fee-for-Service Plans; Fees for Service; Fred Hutchinson Cancer Research Center; Health; Human; Human, General; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Ions; Ligand Binding; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Minor; Modeling; N.I.H. Research Support; Proteins; R01 Mechanism; R01 Program; RPG; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Support, N.I.H.; Researchers; Schools, Medical; Shapes; Site; Techniques; Universities; Washington; analytical ultracentrifugation; base; disease/disorder; gene product; instrument; malignancy; medical schools; member; neoplasm/cancer",Acquisition of Analytical Ultracentrifuge at UW,,27217,ZRG1,Special Emphasis Panel,,1,312504,
7792943,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR027241-01,,NCRR:364762;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,ROCHESTER,UNITED STATES,BIOCHEMISTRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"KIELKOPF, CLARA L;",2642816;,1S10RR027241,01/07/2010,01/06/2011,"AIDS Virus; Advertisements; Advisory Committees; Area; Arts; Bleeding; Cell Communication and Signaling; Cell Signaling; Chromatin; Communities; Computer Programs; Computer software; DNA Replication; DNA Synthesis; DNA biosynthesis; Data; Disease; Disorder; Disputes; Funding; HIV-1; HIV-I; HIV1; Hand; Hemorrhage; Housing; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Instrumentation, Other; Intracellular Communication and Signaling; Investments; Maintenance; Maintenances; Methods and Techniques; Methods, Other; Molecular Weight; Process; Productivity; RNA Splicing; Research; Signal Transduction; Signal Transduction Systems; Signaling; Software; Splicing; Strategic Planning; Students; Task Forces; Techniques; Therapeutic; Training; Universities; biological signal transduction; blood loss; computer program/software; disease/disorder; drug discovery; experience; flexibility; human T cell leukemia virus III; human T lymphotropic virus III; instrument; instrumentation; member; theories",BIAcore T100 for research and drug discovery in Rochester,,27241,ZRG1,Special Emphasis Panel,,1,364762,
7792850,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-028,1S10RR027383-01,,NCRR:498000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"KIM, KANG ;",8252624;,1S10RR027383,01/07/2010,01/06/2011,"3-D Imaging; 3D imaging; Address; Advisory Committees; Analysis, Data; Animals; Biomedical Engineering; Biomedical Research; Blood Vessels; Brachydanio rerio; Cancer Center; Cancers; Cardiac; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cells; Cellular biology; Color; Commit; Danio rerio; Data; Data Analyses; Development; Diagnosis, Ultrasound; Echography; Echotomography; Embryo; Embryonic; Ensure; Environment; Fostering; Frequencies (time pattern); Frequency; Funding; Funding Mechanisms; Future; Guidelines; Human Resources; Image; Imaging Device; Imaging Tool; Imaging, Three-Dimensional; Institutes; Institution; Laboratories; Lateral; Left Ventricular Function; Life; Lung diseases; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rabbits; Mammals, Rodents; Manpower; Medical Imaging, Three Dimensional; Medical Imaging, Ultrasound; Mice; Molecular; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Occupational Health; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organ System, Cardiovascular; Organism; Oryctolagus cuniculus; Pharmacology; Physiologic; Physiological; Physiology; Preclinical Testing; Pulmonary Diseases; Pulmonary Disorder; Rabbit, Domestic; Rabbits; Radio; Regenerative Medicine; Research; Research Resources; Resolution; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Rodent; Rodentia; Rodentias; Scheme; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Technology; Therapeutic; Three-Dimensional Imaging; Time; Tissue Engineering; Training; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States National Institutes of Health; Universities; Variant; Variation; Vascular, Heart; Ventricular Function, Left; Zebra Danio; Zebra Fish; Zebrafish; bioengineering; bioengineering/biomedical engineering; cell biology; circulatory system; clinical relevance; clinically relevant; computer imaging; cost effectiveness; design; designing; diagnostic ultrasound; digital; digital imaging; engineered tissue; experiment; experimental research; experimental study; image processing; image registration; imaging; in vivo; living system; lung disorder; malignancy; molecular imaging; multidisciplinary; neoplasm/cancer; personnel; public health relevance; research study; sonogram; sonography; sound measurement; surgery; ultrasound; ultrasound imaging; ultrasound scanning; vascular",High-resolution ultrasound in-vivo animal imaging system-Vevo2100,,27383,ZRG1,Special Emphasis Panel,,1,498000,
7794795,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR027557-01,,NCRR:499961;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"POLLARD, KENNETH MICHAEL;",1867603;,1S10RR027557,02/01/2010,01/31/2011,"8 year old; AIDS/HIV; AIDS/HIV problem; Aging; Area; Asthma; Autoimmune Status; Autoimmunity; Bronchial Asthma; Cancers; Cell Shape; Cells; Cellular Matrix; Color; Cytofluorometry, Flow; Cytoskeletal System; Cytoskeleton; Disease; Disorder; Electromagnetic, Laser; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Funding; Grippe; HIV/AIDS; HIV/AIDS problem; Hour; Housing; Image; Influenza; Instrumentation, Other; Investigators; Lasers; Malignant Neoplasms; Malignant Tumor; Medicine; Microfluorometry, Flow; Molecular; Mother Cells; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pansy; Population; Progenitor Cells; Protein-Carbohydrate Interaction; Qualifying; Radiation, Laser; Research; Research Institute; Research Personnel; Researchers; Science of Medicine; Senescence; Sepsis; Services; Site; Stem cells; System; System, LOINC Axis 4; Technology; United States National Institutes of Health; Viola; Violet; Work; bloodstream infection; disease/disorder; eight year old; experiment; experimental research; experimental study; flow cytophotometry; flu infection; imaging; influenza infection; instrument; instrumentation; intracellular skeleton; malignancy; member; neoplasm/cancer; public health relevance; research study; self recognition (immune); senescent; tool",BD LSR II Special Order System,,27557,ZRG1,Special Emphasis Panel,,1,499961,
7795386,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR027564-01,,NCRR:417792;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,KANSAS CITY,UNITED STATES,ANATOMY/CELL BIOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"ABRAHAMSON, DALE R;",1892196;,1S10RR027564,01/28/2010,01/27/2011,"Address; Brain; Breast Cancer Cell; Cancers; Cell Communication; Cell Interaction; Cell division; Cell-to-Cell Interaction; Cellular Matrix; Core Facility; Cystic Fibrosis; Cytoskeletal System; Cytoskeleton; Defect; Development; Electron Microscope; Electron Microscopy; Encephalon; Encephalons; Equipment; Fatty Acids; Fecundability; Fecundity; Fertility; Filtration; Financial Support; Fractionation, Filtration; Funding; Gametes; Germ Cells; Germ-Line Cells; Glomerular Capillary; Human Breast Cancer Cell; Intestinal; Intestines; Kansas; Kidney; Laboratory Research; Malignant Neoplasms; Malignant Tumor; Mammals, Primates; Medical center; Microscope; Microscopy, Electron, Scanning; Modeling; Mucoviscidosis; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Oxidative Stress; Pathogenesis; Primates; Property; Property, LOINC Axis 2; Reproductive Cells; Research; Research, Laboratory; Sampling; Sex Cell; Somatic Cell; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; System; System, LOINC Axis 4; Transmission; Universities; Urinary System, Kidney; bowel; digital; dysmotility; dysmotility syndrome; experience; experiment; experimental research; experimental study; initial cell; instrument; intracellular skeleton; malignancy; motility disorder; muscle aging; neoplasm/cancer; neuronal; renal; research study; sexual cell; surgery; transmission process",JEOL JEM-1400 Transmission Electron Microscope with AMT-XR611M Digital Camera Sys,,27564,ZRG1,Special Emphasis Panel,,1,417792,
7795560,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR027744-01,,NCRR:499706;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,LA JOLLA,UNITED STATES,OTHER BASIC SCIENCES,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"FARQUHAR, MARILYN GIST;",1871393;,1S10RR027744,01/28/2010,01/27/2011,"20 year old; Age; Agreement; Arts; Biological; Biology; Cell Communication and Signaling; Cell Signaling; Cells; Communicable Diseases; Cryosectioning; Cryoultramicrotomy; Developmental Biology; Discipline; Electron Microscope; Electron Microscopy Facility; Ensure; Environment; Funding; Future; Image; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intracellular Communication and Signaling; Investigators; Label; Maintenance; Maintenances; Membrane Protein Traffic; Membrane Traffic; Methods and Techniques; Methods, Other; Microscopy; Molecular Medicine; Molecular and Cellular Biology; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurosciences; Organism; Organogenesis; Pathology; Plague; Plastics; Recovery; Research; Research Personnel; Researchers; Resource Sharing; Salaries; Sampling; Schools, Medical; Signal Transduction; Signal Transduction Systems; Signaling; Staining method; Stainings; Stains; System; System, LOINC Axis 4; TEM; Techniques; Time; Transmission; Transmission Electron Microscopy; United States National Institutes of Health; Vascular remodeling; Wages; Work; Yersinia pestis disease; biological signal transduction; cost; imaging; instrument; lens; living system; medical schools; meetings; partial recovery; transmission process; twenty year old",FEI Tecnai G2 Spirit BioTWIN Transmission Electron Microscope,,27744,ZRG1,Special Emphasis Panel,,1,499706,
7794409,S10,RR,1,Y,01/14/2010,01/13/2011,PAR-09-028,1S10RR027764-01,,NCRR:139485;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"RODEN, DAN M;",1885740;,1S10RR027764,01/14/2010,01/13/2011,"0-11 years old; 21+ years old; 5 year old; Academic Medical Centers; Adult; Behavior; Bio-Informatics; Bioinformatics; Cessation of life; Child; Child Youth; Child health care; Childhood; Children (0-21); Clinical; Clinical Research; Clinical Study; Collection; Computer Programs; Computer software; Computerized Medical Record; DNA; DNA Data Banks; DNA Databanks; DNA Databases; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, DNA; Death; Deoxyribonucleic Acid; Discipline; Discipline of obstetrics; Disease; Disorder; Dreams; Electronic Medical Record; Ensure; Environmental Exposure; Funding; Future Generations; Generations; Generations, Future; Genetic; Gestation; Health; Health, Child; Hospitals, Pediatric; Human; Human, Adult; Human, Child; Human, General; Individual; Instrumentation, Other; Knowledge; Length of Life; Life; Link; Longevity; Man (Taxonomy); Man, Modern; Medical Record, Computerized; Medical Research; Medicine; Neurology; Obstetrics; Outcome; Patient Care; Patient Care Delivery; Pediatric Hospitals; Pediatrics; Perinatal; Personal Satisfaction; Pharmacology; Population; Pregnancy; Preparation; RFP; Request for Proposals; Research Resources; Research, Medical; Resources; Sampling; Science of Medicine; Software; System; System, LOINC Axis 4; Therapeutic; Translational Research; Translational Research Enterprise; Translational Science; University Medical Centers; adult human (21+); base; biobank; children; clinical data repository; clinical data warehouse; computer program/software; data repository; disability; disease/disorder; dreaming; five year old; improved; infancy; infantile; innovate; innovation; innovative; instrument; instrumentation; life span; lifespan; pediatric; prevent; preventing; relational database; translation research enterprise; well-being; youngster",Automated DNA Extraction for Small Volume Samples Enabling Pediatric Biobanking,,27764,ZRG1,Special Emphasis Panel,,1,139485,
7794513,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-028,1S10RR027840-01,,NCRR:327585;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SAINT LOUIS,UNITED STATES,NONE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"ACKERMAN, JOSEPH J. H.;",1961327;,1S10RR027840,01/28/2010,01/27/2011,"Animal Disease Models; Animal Model; Animal Models and Related Studies; Animals; Architecture; Artifacts; Arts; Award; Biomedical Research; Care, Health; Cell Communication and Signaling; Cell Culture System; Cell Signaling; Characteristics; Clinic; Common Rat Strains; Communities; Cricetinae; DNA Molecular Biology; Engineering; Engineering / Architecture; Engineerings; Evaluation; Event; Funding; Generations; Hamsters; Healthcare; Home; Home environment; Image; Imaging Procedures; Imaging Techniques; Injury; Institution; Instrumentation, Other; Intracellular Communication and Signaling; Investigators; Laboratories; Laboratory Animal Models; Longitudinal Studies; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Hamsters; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mice; Modeling; Models, Laboratory Animal; Molecular Biology; Morphologic artifacts; Murine; Mus; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Noise; Nuclear Magnetic Resonance Imaging; Pathology; Performance; Phase; Population; Procedures; Programs (PT); Programs [Publication Type]; Rat; Rattus; Research Personnel; Research Resources; Researchers; Resources; Rodent; Rodentia; Rodentias; Running; Sampling; Science; Signal Transduction; Signal Transduction Systems; Signaling; Social Support System; Support System; System; System, LOINC Axis 4; Technics, Imaging; Technology; Time; Transgenic Organisms; Translating; Translatings; United States National Institutes of Health; Universities; Washington; Zeugmatography; biological signal transduction; cost effective; experiment; experimental research; experimental study; imaging; instrument; instrumentation; interest; language translation; long-term study; magnetic field; member; method development; model organism; pre-clinical; preclinical; programs; public health relevance; research study; tool; transgenic",MRI CONSOLE UPGRADE FOR SMALL-ANIMAL 12-T SCANNER,,27840,ZRG1,Special Emphasis Panel,,1,327585,
7794944,S10,RR,1,Y,02/01/2010,01/31/2011,PAR-09-028,1S10RR027916-01,,NCRR:312755;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"PETERSON, KIRK ;",9076649;,1S10RR027916,02/01/2010,01/31/2011,"10 year old; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Applications Grants; Biomedical Engineering; California; Cardiac; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular system; Cardiovascular system (all sites); Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Characteristics; Clinical; Color; DNA Alteration; DNA mutation; Developmental Biology; Diagnosis, Ultrasound; Disease; Disorder; Dysfunction; Echography; Echotomography; Electronics; Embryo; Embryo Development; Embryogenesis; Embryology; Embryology / Fetal Growth; Embryonic; Embryonic Development; Exercise; Exercise, Physical; Faculty; Functional disorder; Gene Alteration; Gene Mutation; Generations; Genetic mutation; Grant Proposals; Grants, Applications; Heart; Image; Imagery; In Situ; Injection of therapeutic agent; Injections; Instrumentation, Other; Intracellular Communication and Signaling; Investigation; Laboratories; Laboratory Study; Mechanics; Medical Imaging, Ultrasound; Medicine; Modeling; Molecular; Mother Cells; Muscle, Cardiac; Muscle, Heart; Myocardium; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organ System, Cardiovascular; Pathogenesis; Performance; Pharmacology; Phase; Physiologic; Physiological; Physiology; Physiopathology; Progenitor Cells; Proteins; Regenerative Medicine; Research; Resolution; Scanning; Science of Anatomy; Science of Medicine; Scientist; Seaweed; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Therapeutic Agents; Trees; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States National Institutes of Health; Universities; Vascular, Heart; Visualization; Work; anatomy; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; biomarker; cardiac muscle; circulatory system; congenital cardiac disorder; congenital heart disease; congenital heart disorder; data management; design; designing; diagnostic ultrasound; disease/disorder; gene product; heart muscle; human disease; imaging; improved; in vivo; innovate; innovation; innovative; instrument; instrumentation; man; man's; member; model organism; new diagnostics; new therapeutics; next generation diagnostics; next generation therapeutics; novel diagnostics; novel therapeutic intervention; novel therapeutics; pathophysiology; postnatal; preclinical study; public health relevance; sonogram; sonography; sound measurement; stem cell biology; ten year old; ultrasound; ultrasound imaging; ultrasound scanning",VisualSonics Ultrasound Imaging System Upgrade,,27916,ZRG1,Special Emphasis Panel,,1,312755,
7836246,S10,RR,1,Y,01/07/2010,01/06/2011,PAR-09-118,1S10RR029229-01,,NCRR:824680;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,ROCHESTER,UNITED STATES,PEDIATRICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"BUSHNELL, TIMOTHY P;",2121871;,1S10RR029229,01/07/2010,01/06/2011,"Acoustic; Acoustics; Area; Autoimmune Diseases; B blood cells; B-Cells; B-Lymphocytes; Biochemical; Blood Precursor Cell; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Clinical; Collaborations; Color; Complex; Containment; Core Facility; Cytofluorometry, Flow; Data; Detection; Development; Electromagnetic, Laser; Electronics; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Generalized Growth; Generations; Genomics; Germinoblastoma; Grippe; Growth; Hematopoietic; Hematopoietic stem cells; Hour; Human; Human, General; Immune response; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Influenza; Instrumentation, Other; Investigators; Lasers; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Man (Taxonomy); Man, Modern; Measures; Microfluorometry, Flow; Modeling; Nematoda; Nematodes; Optics; Patients; Population; Position; Positioning Attribute; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Proteomics; Radiation, Laser; Research Personnel; Researchers; Reticulolymphosarcoma; Retirement; Role; Running; Sampling; Sarcoma, Germinoblastic; Sorting - Cell Movement; Speed; Speed (motion); Stress; T-Cells; T-Lymphocyte; Technology; Thymus-Dependent Lymphocytes; Tissue Growth; Translational Research; Translational Research Enterprise; Translational Science; autoimmune disorder; cell sorting; flow cytophotometry; flu infection; host response; immunoresponse; improved; influenza infection; instrument; instrumentation; novel; ontogeny; pathogen; programs; roundworm; social role; sorting; thymus derived lymphocyte; tool; translation research enterprise","Acquisition Of A High-End, High-Speed Cell Sorter With Bio-Containment Hood",,29229,ZRG1,Special Emphasis Panel,,1,824680,
7838100,S10,RR,1,Y,01/28/2010,01/27/2011,PAR-09-118,1S10RR029300-01,,NCRR:1968422;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,NEW YORK,UNITED STATES,,15,011191520,US,NY,10027,NEW YORK STRUCTURAL BIOLOGY CENTER,"STOKES, DAVID L.;",1886152;,1S10RR029300,01/28/2010,01/27/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Transport, Cell Nucleus; Address; Area; Arts; Autophagocytosis; Bacteria; Biological; Body Tissues; Cell Components; Cell Culture Techniques; Cell Structure; Cell-Cell Adhesion; Cells; Cellular Structures; Cities; Complexes, Macromolecular; Computer Programs; Computer software; DNA; Deoxyribonucleic Acid; Development; Electron Microscope; Electron Microscopy Facility; Endocytosis; Evaluation; Freezing; Goals; HIV; HTLV-III; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Image; Individual; Institution; Instrumentation, Other; Investigators; LAV-HTLV-III; LDL; Lipoproteins, LDL; Low-Density Lipoproteins; Lymphadenopathy-Associated Virus; MSKCC; Macromolecular Complexes; Medicine; Memorial Sloan-Kettering Cancer Center; Neurobiology; New York; New York City; Nuclear Transport; Nucleocytoplasmic Shuttling; Pathogenesis; Phase; Plant Resins; Process; RNA replication; Research Activity; Research Personnel; Researchers; Resins, Plant; Resolution; Sampling; Scanning; Schools, Medical; Science of Medicine; Series; Slice; Software; Structure; Surface; TEM; Technology; Tissues; Transmission; Transmission Electron Microscopy; Universities; Virus-HIV; X ray diffraction; X ray diffraction analysis; X-Ray Diffraction; Xray Diffraction; autophagy; beta-Lipoproteins; college; computer program/software; detector; imaging; instrumentation; light microscopy; macromolecule; medical schools; metropolitan; neurobiological; new technology; nucleocytoplasmic transport; particle; resin; stem; structural biology; tomography; transmission process",Dual-Beam Scanning Electron Microscope for New York Structural Biology Center,,29300,ZRG1,Special Emphasis Panel,,1,1968422,
7761457,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM082307-01A2,,NIGMS:157000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,CHEMISTRY,10,620127691,US,NY,11210,BROOKLYN COLLEGE,"CONTEL, MARIA ;",8762987;,1SC2GM082307,02/01/2010,01/31/2013,"(SP-4-2)-Diamminedichloroplatinum; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex; 1,2-diaminocyclohexane platinum oxalate; 1,2-diamminocyclohexane(trans-1)oxolatoplatinum(II); 1-OHP; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adverse effects; Affinity; Apoptosis; Apoptosis Pathway; Apoptotic; Arts; Assay; Au element; Award; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Blood (Leukemia); CBDCA; CDDP; Cancer cell line; Cancer of the Ovary; Cancers; Carboplatin; Carboplatino; Carcinoma of the Uterine Cervix; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cells; Cervical Carcinoma; Cervix Uteri Carcinoma; Cervix carcinoma; Chemicals; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical; Coenzyme Q-Cytochrome-c Reductase; Coenzyme QH2-Cytochrome-c Reductase; Collaborations; Combination Chemotherapy Regimen; Comparative Study; Complement; Complement Proteins; Complex; Complex III; Cysplatyna; Cytochrome b-c2 Oxidoreductase; DDP; DNA; DNA Damage; DNA Injury; Data; Deoxyribonucleic Acid; Development; Diaminocyclohexane Oxalatoplatinum; Dichlorodiammineplatinum; Dihydroubiquinone-Cytochrome-c Reductase; Drugs; Electron Transport Complex III; Enzymes; Evaluation; Funding; Goals; Gold; Gold Compounds; HIV; HTLV-III; HeLa; Health; Hela Cells; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; IC50; In Vitro; Inhibitory Concentration 50; Investigators; L-OHP cpd; LAV-HTLV-III; Laboratories; Leukemias, General; Ligands; Light; Link; Lymphadenopathy-Associated Virus; Lytotoxicity; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Mission; Mitochondria; Mitochondrial Proteins; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); New York; Nucleic Acids; Oxalatoplatin; Oxalatoplatinum; Oxidation-Reduction; P element; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphorus; Photoradiation; Pilot Projects; Platinum; Platinum Black; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pt element; Public Health; Publishing; Purines; QH(2)-Cytochrome-c Reductase; QH(2)-Ferricytochrome-c Oxidoreductase; Quimioterapia; Redox; Reporting; Research; Research Personnel; Researchers; Resistance; Solid; Solid Neoplasm; Solid Tumor; Structure-Activity Relationship; Synthesis Chemistry; Synthetic Chemistry; System; System, LOINC Axis 4; Techniques; Testing; Texas; Treatment Side Effects; Ubihydroquinone-Cytochrome-c Reductase; Ubiquinol-Cytochrome-c Reductase; Ubiquinol-ferricytochrome-c oxidoreductase; Ubiquinone-Cytochrome b-c2 Oxidoreductase; United States National Institutes of Health; Universities; Virus-HIV; Work; [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum; antitumor agent; base; cancer chemotherapy; chemical structure function; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diammine(cyclobutanedicarboxylato)platinum II; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); cultured cell line; cytotoxic; cytotoxicity; design; designing; drug/agent; human disease; hydrophilicity; improved; in vivo; innovate; innovation; innovative; insight; leukemia; lipophilicity; malignancy; mitochondrial; neoplasm/cancer; novel; ovarian cancer; oxalato (1R,2R-cyclohexanediamine)platinum(II); oxalato (trans-l-1,2-diaminocyclohexane)platinum(II); oxalato-(1,2-cyclohexanediamine)platinum II; oxaliplatin; oxaliplatine; oxidation; oxidation reduction reaction; pilot study; platinum(II)-1,2-cyclohexanediamine oxalate; platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); programs; public health medicine (field); public health relevance; purine; resistant; side effect; single molecule; structure function relationship; therapy adverse effect; trans-l DACH oxalatoplatinum; trans-l diaminocyclohexane oxalatoplatinum; treatment adverse effect; tumor",Organogold phosphorus-containing compounds as antitumor agents," Project Narrative  The proposed studies are important since they will help to design new anticancer pharmaceuticals by understanding the mechanism of action of gold compounds. This has relevance to public health, because of the clinical problems associated to the drugs currently used. Thus, the findings are ultimately expected to be applicable to the health of human beings.",82307,ZGM1,Special Emphasis Panel,A2,1,157000,
7761039,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM089556-01,,NIGMS:155487;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,MISCELLANEOUS,08,620128863,US,NY,100191093,JOHN JAY COLLEGE OF CRIMINAL JUSTICE,"RAUCEO, JASON MALCOLM;",9702532;,1SC2GM089556,02/01/2010,01/31/2013,"ATP-protein phosphotransferase; Adhesions; Anabolism; Antifungal Agents; Antifungal Drug; Antigenic Determinants; Applications Grants; Area; Binding Determinants; Biomedical Research; C. albicans; C.albicans; Candida albicans; Candida glabrata; Caspofungin; Cell Communication and Signaling; Cell Signaling; Cell Wall; Cell membrane; Collaborations; Cytoplasmic Membrane; Development; Epitopes; Event; Extramural Funding Mechanisms; Fostering; Funding; Funding Agency; Funding Source; Fungicides, Therapeutic; Future; Gene Expression; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic Techniques; Genetic analyses; Genetic defect; Grant Proposals; Grants, Applications; Gray; Gray unit of radiation dose; Human; Human, General; Infectious Diseases / Laboratory; Infectious Diseases Research; Intracellular Communication and Signaling; Licensing; Man (Taxonomy); Man, Modern; Mediating; Membrane Proteins; Membrane-Associated Proteins; Microbial Biofilms; Modeling; Molecular Genetic; Molecular Genetics; Monitor; Mortality; Mortality Vital Statistics; Mutation; Ortholog; Orthologous Gene; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Phosphorylation; Pilot Projects; Plasma Membrane; Population; Process; Programs (PT); Programs [Publication Type]; Protein Kinase; Protein Phosphorylation; Proteins; Receptor Protein; Research; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Stress Response Signaling; Students; Surface Proteins; Targetings, Gene; Technics, Genetic; Testing; Therapeutic; Torulopsis glabrata; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Yeast Model System; YeastModel; Yeasts; anti-fungal; antifungals; base; biofilm; biological adaptation to stress; biological signal transduction; biosynthesis; candidaemia; candidemia; career; college; cost; dimorphism; environmental change; gene product; genetic analysis; genome mutation; glycogen synthase a kinase; hydroxyalkyl protein kinase; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; interest; meetings; mutant; novel; pathogen; pathway; phosphorylase b kinase kinase; pilot study; plasmalemma; programs; public health relevance; reaction; crisis; receptor; resistance mechanism; resistant mechanism; response; social role; stress response; stress; reaction; transcription factor",Yeast cell wall damage response pathways," Relevance  Candida albicans is the major fungal pathogen of humans. C. albicans is the 4th most common nosocomial infective agent in the US alone with a high mortality rate amongst candidemia patients. Signaling pathways are critical for adaptation, survival, and pathogenesis. This proposal is relevant as we will determine the signaling mechanisms that govern the response to antifungal drugs.",89556,ZGM1,Special Emphasis Panel,,1,155487,
7761697,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM089601-01,,NIGMS:132809;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,CHEMISTRY,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"BOLIG, ANDREW D.;",9765779;,1SC2GM089601,02/01/2010,01/31/2013,"Animal Model; Animal Models and Related Studies; Animals; Architecture; Area; Basic Research; Basic Science; Biocompatible; Biocompatible Materials; Biomaterials; Blood; Care, Health; Catalysis; Characteristics; Chemicals; Chemistry; Collaborations; Communities; Consultations; Crystallization; Data; Development; Devices; Education; Educational aspects; Elements; Endocrine Disrupter; Endocrine Disrupting Chemicals; Endocrine Disruptors; Endocrine disrupting agent; Endocrine disruption; Engineering / Architecture; Esters; Ethene Homopolymers; Ethylene Homopolymers; Ethylene Polymers; Exhibits; FTIR; FTIR spectroscopy; Fourier transform infrared spectroscopy; Funding; Goals; Hazards, Health; Health; Health Care Providers; Health Hazards; Health Personnel; Health, Reproductive; Healthcare; Healthcare Providers; Healthcare worker; Human; Human, General; Industry; Instrumentation, Other; Investigators; Journals; Knowledge; Leadership; Legislation; Libraries; Life; Literature; Magazine; Man (Taxonomy); Man, Modern; Medical; Medical Device; Mentors; Method LOINC Axis 6; Methodology; Methods; Mission; Molecular Weight; NIH; National Institutes of Health; National Institutes of Health (U.S.); Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pattern; Performance; Phase; Plasticizers; Plastics; Polyesters; Polyethylenes; Polymers; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Public Health; Publications; Recruitment Activity; Reproductive Health; Research; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Blood; Risk; Science of Chemistry; Scientific Publication; Scientist; Screening procedure; Series; Societies; Source; Spectroscopy, Fourier Transform Infrared; Statutes and Laws; Structure; Students; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicities; Toxicology; Toy; Transition Elements; Underrepresented Minority; United States National Institutes of Health; Variant; Variation; Weight; Work; base; burden of disease; burden of illness; cancer risk; career; career development; catalyst; conference; copolymer; design; designing; disability; disease burden; endocrine disrupting; endocrine disrupting compound; experience; flexibility; hazard; health care personnel; health care worker; health provider; healthcare personnel; human male; improved; instrumentation; interest; macromolecule; male; medical personnel; migration; model organism; monomer; phthalates; physical property; prevent; preventing; programs; public health medicine (field); public health relevance; recruit; reproductive; reproductive development; resistant; screening; screenings; skills; small molecule; surgery; symposium; transition metal; treatment provider; under-represented minority; underserved minority; years of life lost to disability; years of life lost to disease",Synthesis and Screening of Non-Migrating Plasticizers for Medical Devices," The impact of the proposed research on public health is considerable.  These studies have the potential to provide  replacements for substances of known reproductive toxicity to which all humans are exposed, many at elevated levels in  medical procedures.  The development of non-migrating  plasticizers will allow the continued necessary use of flexible  plastics materials without exposing patients to reproductive health hazards. ",89601,ZGM1,Special Emphasis Panel,,1,132809,
7761672,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM089602-01,,NIGMS:122500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NORTHRIDGE,UNITED STATES,BIOLOGY,27,055752331,US,CA,913308232,CALIFORNIA STATE UNIVERSITY NORTHRIDGE,"HONG, RAY L;",9366369;,1SC2GM089602,02/01/2010,01/31/2013,"Afferent Neurons; Animals; Arthropoda; Arthropods; Asians; Beetles; Behavior; Behavioral; Behavioral Genetics; Brugia malayi; C elegans; C.elegans; Caenorhabditis elegans; Candidate Disease Gene; Candidate Gene; Chemicals; Chemotaxis; Coleoptera; Communication; Development; Developmental Process; Disease; Disorder; Engineering; Engineerings; Environment; Evolution; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinants of Behavior; Genetic Markers; Genetic Screening; Genetic defect; Genetics, Behavioral; Genetics, Other; Genomics; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Homeo Domain; Human; Human, General; Insecta; Insects; Intercept; Invertebrata; Invertebrates; Invertebrates, General; Invertebrates, Insects; Knowledge; Length; Lesion; Life; Logic; Man (Taxonomy); Man, Modern; Maps; Mediating; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Mutation; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Odors; Olfaction; Olfactions; Order Coleoptera; Other Genetics; Output; Parasitic nematode; Partner in relationship; Pathway interactions; Pattern; Perception; Phenotype; Pheromone; Physiology; Postdoc; Postdoctoral Fellow; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Receptor Protein; Research Associate; Science of neurophysiology; Sensory Cell Afferent Neuron; Smell; Smell Perception; Soil; Specificity; System; System, LOINC Axis 4; TRP channel; TRP protein; Time; Transgenic Organisms; Translating; Translatings; Variant; Variation; Wing; Work; behavior genetics; comparative; disease/disorder; gain of function; gene product; genome mutation; homeodomain; human disease; improved; language translation; mate; molecular marker; mutant; neuronal; neurophysiology; oriental; pathway; positional cloning; post-doc; post-doctoral; preference; public health relevance; receptor; response; reverse genetics; roundworm; transgenic; vector",Molecular Characterization of Insect Pheromone Chemosensory Mutants in Nematodes," ) Project Narrative The molecular physiology of insect pheromone attraction will have a direct impact on our understanding of olfaction in nematodes, as well as chemosensation in general. Our proposal has the potential to be translated into improving treatments against parasitic nematodes by targeting their means of perceiving their environment and to elucidate the overall diversity of molecular pathways in animal chemosensation.",89602,ZGM1,Special Emphasis Panel,,1,122500,
7762116,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM089622-01,,NIGMS:129400;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,POMONA,UNITED STATES,BIOLOGY,38,028929438,US,CA,917682557,CALIFORNIA STATE POLY U POMONA,"LIU, JUNJUN ;",9757877;,1SC2GM089622,02/01/2010,01/31/2013,"ATP-protein phosphotransferase; Affect; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Approaches to prevention; Binding Sites; California; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer-Promoting Gene; Cancers; Cell Cycle; Cell Cycle Control; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Division Cycle; Cell division; Cellular biology; Chemotherapeutic Agents, Neoplastic Disease; Chromosomes; Combining Site; Cyclin B; Cytokinesis; Cytoplasmic Division; Data; Deubiquitination; Development; Disease; Disorder; EC 2.7; Esteroproteases; Event; Family; Foundations; Gene Expression; GeneHomolog; Goals; Grant; Histone H2A; Histones; Homolog; Homologous Gene; Homologue; Human; Human Ubiquitin; Human, General; In Vitro; Journals; Kinases; Knowledge; Laboratory Research; Lead; Literature; M Phase; M phase (cell cycle); Magazine; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Manuscripts; Mediating; Mitosis; Mitosis Stage; Mitotic; Modification; Molecular; Oncogenes; Oncogenesis; Outcome; P62 (cyclin B); PLK; PLK gene product; PLK1 protein, human; Pb element; Peer Review; Peptidases; Peptide Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Platanna; Play; Plk1 protein; Polo-Box Domain; Polo-Like Kinase; Prevention approach; Principal Investigator; Process; Proteases; Protein Kinase; Protein Phosphorylation; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteinases; Proteolytic Enzymes; Publications; Reactive Site; Regulation; Regulatory Pathway; Reporting; Research; Research Proposals; Research, Laboratory; Rest; Role; STPK13 gene product; Scientific Publication; Serine Kinase; Serine-Threonine Kinases; Site; Structure; System; System, LOINC Axis 4; Testing; Threonine Kinase; Transforming Genes; Transphosphorylases; Tumor-Specific Treatment Agents; Universities; Work; Xenopus; Xenopus laevis; anaphase-promoting complex; anticancer agent; anticancer drug; anticancer therapy; base; cancer cell; cancer therapy; cdc13 Protein; cell biology; cell transformation; cyclosome; disease/disorder; enzyme substrate; experience; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human PLK1 protein; human disease; hydroxyalkyl protein kinase; in vivo; innovate; innovation; innovative; malignancy; neoplasm/cancer; novel; overexpression; p56cdc13; phosphorylase b kinase kinase; polo-like kinase 1; public health relevance; social role; transformed cells; tumor growth; tumorigenesis",Regulation Of A Novel Xenopus Polo-Like Kinase 1 Substrate, Project Narrative Polo-like kinase 1 is a key cell cycle regulator and has recently emerged as a promising target for anti-cancer drugs. This application proposes to study the regulation of a novel substrate for polo-like kinase 1. The study is expected to reveal a new mechanism of cell cycle control and may also provide a foundation for developing innovative strategies for treating human diseases such as cancer.,89622,ZGM1,Special Emphasis Panel,,1,129400,
7762560,SC2,GM,1,,02/01/2010,01/31/2011,PAR-08-027,1SC2GM089642-01,,NIGMS:104443;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MAYAGUEZ,UNITED STATES,ENGINEERING (ALL TYPES),,175303262,US,PR,006819000,UNIVERSITY OF PUERTO RICO MAYAGUEZ,"RAMIREZ-VICK, JAIME E;",7756507;,1SC2GM089642,02/01/2010,01/31/2013,"2ar peptide; 4-Carboxyglutamic Protein, Bone; Adhesions; Adhesives; Adipogenesis Inhibitory Factor; Adsorption; Affect; Alloys; Applications Grants; Area; Arg-Gly-Asp; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain; Arts; Assay; Atomic Force Microscope; Atomic Force Microscopy; B-Protein; Binding; Binding (Molecular Function); Bioassay; Biocompatible Materials; Biologic Assays; Biological Assay; Biomaterials; Blood Plasma; Blood Serum; Body Tissues; Bone Formation; Bone Tissue; Bone gamma-Carboxyglutamic Acid Protein; Calcium-Binding Protein, Vitamin K-Dependent; Catalase B; Cell Adhesion; Cell Communication; Cell Culture Techniques; Cell Function; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell physiology; Cell surface; Cell-Extracellular Matrix; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Chemicals; Chemistry; Clinic; Clinical; Cold-Insoluble Globulins; Collagen Type I; Complement S-Protein; Complex; Coxa; Cultured Cells; Data; Dental; Deposit; Deposition; Detection; Development; Diffusion; Distant; Drug Formulations; Dysfunction; ECM; Economics; Electron Probe Microanalysis; Engineering; Engineerings; Environment; Epibolin; Eta-1 protein; Eta-1-Op protein; Exhibits; Extracellular Matrix; FN1; FNZ; FTIR; FTIR spectroscopy; Fibronectin 1; Fibronectins; Film; Fluorescence Microscopy; Force Microscopy; Formulation; Formulations, Drug; Foundations; Fourier transform infrared spectroscopy; Functional disorder; Gene Expression; Genes; Gla Protein, Bone; Glycoprotein 75; Glycoprotein GP-2; Goals; Grant Proposals; Grants, Applications; Heparin Binding; Hip; Hip region structure; Hour; IL-11; IL11; Immunofluorescence Microscopy; Implant; In Vitro; Institution; Interleukin-11; International; Investigation; Knowledge; LETS Proteins; Laminin; Large External Transformation-Sensitive Protein; Laser Scanning Confocal Microscopy; Libraries; Life; Liquid substance; Location; Marketing; Measurement; Mechanics; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Messenger RNA; Metals; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Microscopy, Electron, X-Ray Microanalysis; Microscopy, Fluorescence; Microscopy, Immunofluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Morphology; Mother Cells; Motility; Motility, Cellular; ODF; OPGL; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Osseointegration; Osteoblasts; Osteocalcin; Osteogenesis; Outcome; Oxides; Peer Review; Physiology; Physiopathology; Plasma; Population; Population Distributions; Procedures; Process; Progenitor Cells; Prosthesis; Prosthetic device; Prosthetics; Protein Conformation; Proteins; Publications; RANKL; RGD; RGD (peptide); RGD (sequence); RGD Cell Adhesion Domain; RGD Domain; RGD Motif; RGD Tripeptide Sequence; RGD tripeptide; RNA, Messenger; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Research; Research Activity; Reticuloendothelial System, Serum, Plasma; Roentgen Rays; Scanning Force Microscopy; Science; Science of Chemistry; Scientific Publication; Scientist; Screening procedure; Serum; Serum Spreading Factor; Serum, Plasma; Spectrometry; Spectroscopy; Spectroscopy, Fourier Transform Infrared; Spectrum Analyses; Spectrum Analysis; Staging; Stem cells; Stimulus; Subcellular Process; Surface; Surface Properties; TNFSF11; TNFSF11 gene; TRP-1; TYRP; TYRP1; TYRP1 protein, human; Techniques; Technology; Testing; Therapeutic; Thick; Thickness; Ti element; Tissue Engineering; Tissue Model; Tissues; Titanium; Training; Transcript; Translating; Translatings; Type 1 Collagen; Tyrosinase-Related Protein 1; VTN; Vitamin K-Dependent Bone Protein; Vitronectin; X-Radiation; X-Ray Emission Spectrometry, Electron Microscopic; X-Ray Emission Spectrometry, Electron Probe; X-Ray Microanalysis; X-Ray Microanalysis, Electron Microscopic; X-Ray Microanalysis, Electron Probe; X-Rays; Xrays; alpha 2-Surface Binding Glycoprotein; arginyl-glycyl-aspartic acid; base; bone healing; bone sialoprotein 1; bone sialoprotein I; brown locus protein, human; cell behavior; cell motility; cell type; cold temperature; combinatorial; conference; confocal scanning microscopy; conformation; conformational state; early T-lympocyte activation-1 protein; electron probe spectrometry; engineered tissue; fluid; gene product; glycoprotein-75, human; gp75 TRP-1, brown protein, human; graduate student; hRANKL2; human TYRP1 protein; human tissue; implant material; improved; in vivo; interest; language translation; liquid; low temperature; mRNA; melanoma antigen gp75, human; metal oxide; migration; nano; nano structured; nanostructured; novel; osteogenic; osteopontin; pathophysiology; phosphoprotein I, 2aR; protein distribution; public health relevance; sOdf; scaffold; scaffolding; screening; screenings; secreted phosphoprotein 1; sialoprotein 1; stem cell differentiation; symposium; tyrosinase-related protein 1, human; vapor",Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions," Project Narrative With a U.S. Prosthetic Implant market of about $1 billion a year and growing at a rate of 10% a year, any improvement in osseointegration and life of the prosthetic implant will have a drastic economic effect, especially if one takes into consideration that up to 30% of the implants in procedures such as hip replacement do not show appropriate osseointegration. The proposed project aims to improve the number of candidate biomaterials screened for improved osseointegration by investigating the effect of the material surface properties and protein adsorption on osteogenic mesenchymal stem cell behavior, using state of the art surface characterization and gene expression technologies.",89642,ZGM1,Special Emphasis Panel,,1,104443,
7871860,T32,EY,1,,04/01/2010,03/31/2011,PA-08-226,1T32EY020485-01,,NEI:159829;,2010,NATIONAL EYE INSTITUTE,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"BARRES, BEN A (contact);LIAO, YAPING J;",1891951 (contact);1904416;,1T32EY020485,04/01/2010,03/31/2015,Research Training; Training Programs; Vision research,Vision Research Training Program,,20485,ZEY1,Special Emphasis Panel,,1,159829,
7849165,T35,EY,1,,01/08/2010,12/31/2010,,1T35EY020481-01,,NEI:45680;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,OPHTHALMOLOGY,14,152652764,US,NY,10036,STATE COLLEGE OF OPTOMETRY,"CIUFFREDA, KENNETH JOSEPH;",1969903;,1T35EY020481,01/08/2010,12/31/2014,"Admission; Admission activity; Area; Award; Binding; Binding (Molecular Function); Biochemistry; Career Choice; Cell Communication and Signaling; Cell Signaling; Chemistry, Biological; Clinic; Clinical; Clinical Research; Clinical Study; Collaborations; Communities; Complement; Complement Proteins; Computer Vision Systems; Computers; Connecticut; Consult; Criteria, Selection; Data; Discipline; Doctor of Philosophy; E-Mail; Educational workshop; Electronic Mail; Electronics; Email; Enrollment; Equipment; Ethics; Ethics Committees, Research; Ethics, Research; Experimental Designs; Eye; Eyeball; Faculty; Feedback; Fostering; Funding; Future; Goals; Grant; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Hearing; History; Hour; IRBs; Individual; Institutes; Institution; Institutional Review Boards; International; Interview; Intracellular Communication and Signaling; Investigation; Investigators; Journals; Knowledge; Laboratories; Laboratory Research; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Libraries; Literature; Magazine; Manuscripts; Measures; Mentors; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); Ocular Pathology; Optics; Optometries; Optometry; Oral; Outcome Measure; Paper; Patient Care; Patient Care Delivery; Peer Review; Ph.D.; PhD; Physiologic; Physiological; Physiology; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Psychology; Psychophysic; Psychophysics; Public Health; Publications; Publishing; Reading; Recommendation; Recording of previous events; Reporting; Research; Research Activity; Research Associate; Research Ethics; Research Ethics Committees; Research Personnel; Research Training; Research, Laboratory; Researchers; Respondent; Role; Running; Schools; Science; Science of Statistics; Scientific Publication; Scientist; Selection Criteria; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Statistics; Structure; Students; Suggestion; Survey Instrument; Surveys; System; System, LOINC Axis 4; Time; Training; Travel; United States National Institutes of Health; Universities; Vision; Vision Systems, Computer; Vision research; Visual Perception; Wood; Wood material; Workshop; Writing; abstracting; base; biological signal transduction; career; college; computer vision; conference; enroll; experience; graduate student; hearing perception; improved; interest; lectures; meetings; metropolitan; ocular motor; ocularmotor; oculomotor; post-doc; post-doctoral; programs; public health medicine (field); public health relevance; response; satisfaction; social role; sound perception; square foot; statistics; symposium; vision science; willingness",Short-term Training Students in Health Professional Schools,,20481,ZEY1,Special Emphasis Panel,,1,45680,
7783391,U01,NS,1,,04/01/2010,03/31/2011,PAR-08-233,1U01NS062676-01A2,,NINDS:666013;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,EMERGENCY MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"STEIN, DONALD G;",2451596;,1U01NS062676,04/01/2010,03/31/2013,"21+ years old; Acquired brain injury; Acute; Adult; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Area; Arts; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Assay; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blinded; Blood Pressure, High; Brain; Brain Injuries; Cerebral Infarction; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Characteristics; Clinical; Clinical Evaluation; Clinical Testing; Clinical Treatment; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Cognitive; Common Rat Strains; Conditioning Therapy; Contracting Opportunities; Contracts; Cooperative Agreements; Cooperative Agreements, U-Series; Corpus Luteum Hormone; Data; Delta4-pregnene-3,20-dione; Development; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Therapy; Drugs; Empirical Research; Encephalon; Encephalons; Evaluation; Exclusion; FLR; Failure (biologic function); Female; Future; Gender; Goals; Guidelines; Human; Human, Adult; Human, General; Hypertension; Infarction; Injury; Ischemia; Ischemic Stroke; Lab Findings; Laboratories; Laboratory Finding; Lead; Lesion; Life Style Modification; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medication; Middle Cerebral Artery Occlusion; Modeling; Mortality; Mortality Vital Statistics; Motor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, Brain; Neurologic; Neurological; Occlusion, Middle Cerebral Artery; Outcome; Outcome Study; PBO; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Physiologic; Physiological; Placebos; Policies; Population; Populations at Risk; Pregn-4-ene-3,20-dione; Pregnenedione; Principal Investigator; Progesterone; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Publishing; Randomized; Rat; Rattus; Recommendation; Recovery; Recovery of Function; Research; Resolution; Risk; Risk Factors; Safety; Sex Characteristics; Sex Differences; Sham Treatment; Stroke; Study, Outcome; Suggestion; Testing; Therapeutic; Therapeutic Progesterone; Time; Translational Research; Translational Research Enterprise; Translational Science; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; U-Series Cooperative Agreements; United States National Institutes of Health; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; adult human (21+); base; behavior intervention; behavior test; behavioral intervention; behavioral test; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; clinical investigation; clinical relevance; clinical test; clinically relevant; cognitive recovery; comparative efficacy; drug development; drug/agent; expectation; experience; experiment; experimental research; experimental study; failure; functional outcomes; functional recovery; gender difference; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; improved; infarct; male; meetings; mid life; mid-life; middle age; middle aged; midlife; model organism; motor deficit; neurosteroids; normotensive; pre-clinical; preclinical; programs; public health medicine (field); randomisation; randomization; randomly assigned; research clinical testing; research study; response; restoration; sex; sexual dimorphism (noncellular); sham therapy; stroke; stroke therapy; translation research enterprise; traumatic brain damage; treatment effect; trial regimen; trial treatment",Progesterone in the Treatment of ischemic Stroke,,62676,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,A2,1,666013,
7768241,U01,NS,1,,02/01/2010,01/31/2011,PAR-08-233,1U01NS066915-01,,NINDS:491655;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LEXINGTON,UNITED STATES,PHYSICAL MEDICINE & REHAB,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"SPRINGER, JOE E;",7879184;,1U01NS066915,02/01/2010,01/31/2014,"Acute; Acute myocardial infarct; Acute myocardial infarction; Assay; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Care, Health; Cell Death; Ciclosporin; Clinical; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; CsA; Cyclosporin A; Cyclosporine; Cyclosporine A; Cyclosporines; Cyclosporins; Dose; Drug Design; Drug Kinetics; Dysfunction; Early treatment; Event; Exhibits; Functional disorder; Health; Healthcare; Human; Human, General; Immunosuppressants; Immunosuppressive Agents; Individual; Ischemia-Reperfusion Injury; Life; Lytotoxicity; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mitochondria; Modeling; Myelopathy, Traumatic; Permeability; Pharmacokinetics; Phase; Physiopathology; Process; Property; Property, LOINC Axis 2; Rat; Rattus; Recovery; Recovery of Function; Reperfusion Damage; Reperfusion Injury; Sandimmun; SangCya; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Testing; Therapeutic; Time; Tissues; Toxic effect; Toxicities; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; United States; analog; base; clinical investigation; clinical relevance; clinically relevant; cost; cytotoxicity; effective therapy; experiment; experimental research; experimental study; functional outcomes; functional recovery; immunosuppressive; improved; in vivo; inhibitor; inhibitor/antagonist; meetings; mitochondrial; necrocytosis; neoral; pathophysiology; preclinical study; research study; sandimmune; traumatic brain damage",NIM811 FOR THE TREATMENT OF ACUTE SPINAL CORD INJURY,,66915,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,1,491655,
7787802,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063020-01,,NICHD:198162;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CHICAGO,UNITED STATES,OBSTETRICS & GYNECOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"GROBMAN, WILLIAM ADAM;",6958803;,1U10HD063020,01/10/2010,12/31/2012,"Accounting; Causality; Characteristics; Clinical; Collaborations; Data; Data Coordinating Center; Data Coordination Center; Development; Diagnosis, Ultrasound; Discipline of obstetrics; Echography; Echotomography; Ensure; Etiology; Generalized Growth; Genetic; Growth; Health; Infrastructure; Investigation; Investigators; Laboratories; Location; Medical Imaging, Ultrasound; Medical Inspection; Michigan; Multicenter Trials; NICHD; National Institute of Child Health and Human Development; Nursing Research; Observational Study; Obstetrics; Organization Charts; PROV; Patient Recruitments; Patients; Physical Examination; Physiologic; Physiological; Population; Pregnancy Outcome; Premature Birth; Preterm Birth; Prevention; Procedures; Process; Protocol; Protocols documentation; Provider; Recruitment Activity; Recruitments, Patient; Research; Research Infrastructure; Research Personnel; Researchers; Risk; Site; Study Subject; Survey Instrument; Surveys; Therapeutic; Tissue Growth; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; Woman; diagnostic ultrasound; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experience; experiment; experimental research; experimental study; fetal; innovate; innovation; innovative; meetings; multidisciplinary; novel; ontogeny; organizational structure; premature childbirth; premature delivery; preterm delivery; prospective; public health relevance; recruit; research study; sample collection; sonogram; sonography; sound measurement; specimen collection; ultrasound; ultrasound imaging; ultrasound scanning",Preterm Birth in Nulliparous Women:  An Understudied Population at Great Risk ,,63020,ZHD1,Special Emphasis Panel,,1,198162,
7789832,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063036-01,,NICHD:2969016;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"PARKER, CORETTE B;",6111273;,1U10HD063036,01/10/2010,12/31/2013,"Advisory Committees; Analysis, Data; Articulation; Attention; Back; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Booklets; Brochures; Capitate; Capitate Bone; Certification; Communication; Consent Documents; Consent Forms; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Coordination Center; Development; Doctor of Philosophy; Doctor of Public Health; Dorsum; Dr.P.H.; Enrollment; Ensure; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethics Committees, Research; Genetic; Gestation; Health; Human Resources; IRBs; Individual; Informed Consent Documents; Informed Consent Forms; Infrastructure; Institutional Review Boards; Interview; Investigators; Joints; Knowledge; Leadership; Logistics; Manpower; Manuals; Measurement; Medical; Method LOINC Axis 6; Methodology; Methods; Monitor; NICHD; National Institute of Child Health and Human Development; Operation; Operative Procedures; Operative Surgical Procedures; Pamphlets; Paper; Patients; Perinatal Epidemiology; Ph.D.; PhD; Phase; Physicians; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Preterm Birth; Principal Investigator; Procedures; Process; Protocol; Protocols documentation; Publications; Quality Control; Reporting; Research; Research Design; Research Ethics Committees; Research Infrastructure; Research Personnel; Researchers; Risk; Running; SCHED; Safety; Sample Size; Schedule; Science of Statistics; Scientific Publication; Scientist; Screening procedure; Security; Site Visit; Sound; Sound - physical agent; Statistics; Stillbirth; Structure of capitate bone; Study Section; Study Type; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Teleconferences; Testing; Texas; Training; Translations; Universities; Visit; Woman; Work; base; biomarker; capitate bone; clinical research site; clinical site; data management; enroll; experience; fetal medicine; improved; instrument; meetings; member; personnel; premature childbirth; premature delivery; preterm delivery; protocol development; public health relevance; quality assurance; screening; screenings; sound; statistics; statistics/biometry; study design; surgery; web site",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63036,ZHD1,Special Emphasis Panel,,1,2969016,
7789198,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063037-01,,NICHD:187920;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,INDIANAPOLIS,UNITED STATES,OBSTETRICS & GYNECOLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"HAAS, DAVID MICHAEL;",8471386;,1U10HD063037,01/10/2010,12/31/2012,"0-11 years old; 0-6 weeks old; Accounting; Address; Affect; Birth Rate; Candidate Disease Gene; Candidate Gene; Care, Health; Causality; Child; Child Youth; Children (0-21); Clinical Research; Clinical Study; Complex; Complication; Corpus Luteum Hormone; DNA; Delta4-pregnene-3,20-dione; Deoxyribonucleic Acid; Diagnosis; Diagnostic; Disease; Disorder; Ensure; Environment; Environmental Factor; Environmental Risk Factor; Etiology; Family; GWAS; Genes; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Risk; Genetic Susceptibility; Genetic screening method; Genomics; Gestation; Goals; Health Care Costs; Health Costs; Health Expenditures; Healthcare; Healthcare Costs; Heterogeneity, Population; High Risk Woman; History; Human, Child; Infant, Newborn; Inherited Predisposition; Inherited Susceptibility; Institution; Intervention; Intervention Strategies; Investigators; Measures; Mortality; Mortality Vital Statistics; Newborn Infant; Newborns; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Outcomes Research; PROV; Physiologic; Physiological; Polymorphism (Genetics); Polymorphism, Genetic; Population Heterogeneity; Pregn-4-ene-3,20-dione; Pregnancy; Pregnancy Complications; Pregnant Women; Pregnenedione; Premature Birth; Preterm Birth; Preventive; Process; Progesterone; Proteomics; Provider; Proxy; Public Health; Publishing; Recording of previous events; Recurrence; Recurrent; Reporting; Research; Research Personnel; Research Specimen; Research, Outcomes; Researchers; Risk; Risk Factors; Sample Size; Sampling; Series; Societies; Specimen; Supplementation; Technology; Testing; Therapeutic; Therapeutic Human Experimentation; Therapeutic Progesterone; Therapeutic Research; United States; Woman; biobank; biomarker; children; cost; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; diverse populations; environment effect on gene; environmental risk; gene environment interaction; genetic etiology; genetic mechanism of disease; genetic testing; genetic variant; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; health care expenditure; heterogeneous population; high risk; improved; innovate; innovation; innovative; insight; intervention design; interventional strategy; neonatal morbidity; new technology; newborn human (0-6 weeks); novel; polymorphism; pregnant; premature childbirth; premature delivery; preterm delivery; prevent; preventing; public health medicine (field); public health relevance; success; technological innovation; therapy design; treatment design; whole genome association studies; whole genome association study; women at high risk; youngster",Dissecting the Genetic Etiology of Preterm Birth in Nulliparous Women,,63037,ZHD1,Special Emphasis Panel,,1,187920,
7790819,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063041-01,,NICHD:215467;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PITTSBURGH,UNITED STATES,,14,119132785,US,PA,152133180,MAGEE-WOMEN'S RES INST AND FOUNDATION,"SIMHAN, HYAGRIV N;",7895323;,1U10HD063041,01/10/2010,12/31/2012,"Address; Affect; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Area; Bacterial Vaginosis; Biological Function; Biological Process; Birth; Black race; Causality; Characteristics; Charge; Clinical; Clinical Research; Clinical Study; Cohort Studies; Collaborations; Collection; Concurrent Studies; Data; Development; Diagnosis, Ultrasound; Diagnostic tests; Discipline of obstetrics; Early Placental Phase; Echography; Echotomography; Enrollment; Environment; Environmental Exposure; Environmental Factor; Environmental Risk Factor; Epidemiology; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Etiology; Expertise, Technical; Faculty; Fetus; First Pregnancy Trimester; Future; Generalized Growth; Genes; Genetic; Genetic Polymorphism; Genital; Genital system; Genomics; Genotype; Gestation; Growth; HOSP; History; Hospitals; INFLM; Image; Immunity; Incidence; Infection; Inflammation; Inflammatory; Infrastructure; Intervention; Intervention Strategies; Intervention Studies; Knowledge; Lead; Mediating; Medical Imaging, Ultrasound; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multicenter Studies; Nature; Negroes; Neonatal Mortality; Obstetrics; Operations Research; Parturition; Pathology; Patient Self-Report; Patients; Pb element; Physiologic; Physiological; Placental Development; Placentation; Polymorphism (Genetics); Polymorphism, Genetic; Population; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Pregnant Women; Premature Birth; Prenatal care; Preterm Birth; Prevention; Proteomics; Public Health; Race; Racial Group; Recording of previous events; Research Infrastructure; Research Resources; Resources; Risk; Sampling; Sampling Studies; Screening procedure; Self-Report; Site; Stocks, Racial; System; System, LOINC Axis 4; Technical Expertise; Tissue Growth; Trimester, First; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; VIT D; Vaginitis, Bacterial; Vaginitis, Nonspecific; Vitamin D; Woman; base; cigarette smoking; clinical research site; clinical site; cohort; cytokine; design; designing; diagnostic ultrasound; disease causation; disease etiology; disease/disorder etiology; disorder etiology; enroll; environment effect on gene; environmental risk; experience; fetal; gene environment interaction; heavy metal Pb; heavy metal lead; imaging; interventional strategy; maternal cigarette smoking; maternal smoking; neonatal mortalities; newborn mortality; ontogeny; polymorphism; premature childbirth; premature delivery; preterm delivery; public health medicine (field); public health relevance; response; screening; screenings; smoke cigarette; sonogram; sonography; sound measurement; ultrasound; ultrasound imaging; ultrasound scanning; urogenital system (genital part)",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63041,ZHD1,Special Emphasis Panel,,1,215467,
7791061,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063046-01,,NICHD:198902;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,IRVINE,UNITED STATES,OBSTETRICS & GYNECOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"WING, DEBORAH A;",6438292;,1U10HD063046,01/10/2010,12/31/2012,"0-11 years old; Acculturation; Acculturations; Adopted; Affect; African American; Afro American; Afroamerican; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; American; American Indian; American Indians; Analysis, Data; Appointment; Asia, Southeastern; Asian Americans; Asians; Awareness; Awarenesses; Behavior; Behavioral; Belief; Bio-Informatics; Bioinformatics; Biological; Biological Terrorism; Bioterrorism; Birth; Birth Rate; Black Populations; Black or African American; California; Care, Health; Care, Managed; Caring; Causality; Central America; Central American; Characteristics; Child; Child Youth; Child health care; Children (0-21); China; Clinic; Clinical; Clinical Pathology; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collection; Communities; Community Outreach; Contracting Opportunities; Contracts; Costa Rica; Country; County; Cultural Assimilation; Cultural Backgrounds; DNA, Mitochondrial; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Detection; Diagnosis, Ultrasound; Discipline of obstetrics; Disease; Disorder; Doctor of Philosophy; Doppler velocimetry; Dysfunction; Early Placental Phase; Echography; Echotomography; Economics; El Salvador; Elements; Enrollment; Ensure; Environmental Factor; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Etiology; Evaluation; Exclusion; Faculty; Fellowship; Fetal Age; Fetal Growth; Fetal Maturity, Chronologic; First Births; First Pregnancy Trimester; Frequencies (time pattern); Frequency; Functional disorder; Funding; Generalized Growth; Genetic; Genetic Determinism; Genetic Medicine; Genomics; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Geography; Gestation; Gestational Age; Goals; Grant; Group Practice; Growth; Growth, Fetal; Gynecology; Hawaii; Hawaiian; Hawaiian population; Health, Child; Healthcare; Hispanic Populations; Hispanics; Hispanics or Latinos; Household; Housing; Human Resources; Human, Child; Immigrant; Indians, American; Individual; Industry; Infrastructure; Institutes; Insurance Coverage; Insurance Status; Intervention; Intervention Strategies; Investigation; Investigators; Laboratory Research; Latino; Latino Population; Lead; Leadership; Letters; Los Angeles; Mainland China; Managed Care; Manpower; Maternal Age; MeSH Descriptors Class 4; Medical Imaging, Ultrasound; Medical center; Methods; Mexican; Mexico; Mission; Mitochondria; Mitochondrial DNA; Molecular; Molecular Genetic; Molecular Genetics; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NICHD; NIH; Nafion; National Children's Study; National Institute of Child Health and Human Development; National Institutes of Health; National Institutes of Health (U.S.); Native Alaskan; Native Americans; Nature; Neonatal; Neonatology; Nicaragua; Non-Hispanic; Not Hispanic or Latino; Obesity; Obstetrics; Oranges; Outcome; Outreach, Community; Pacific Island Americans; Pacific Islander; Pacific Islander American; Participant; Parturition; Pathology, Clinical; Patient Education; Patient Instruction; Patient Training; Patients; Pb element; Perinatal; Perinatology; Ph.D.; PhD; Pharmacies; Pharmacy facility; Physicians; Physiopathology; Population; Population Sizes; Pregnancy; Pregnancy Trimester, First; Premature Birth; Prenatal care; Preterm Birth; Prevention; Principal Investigator; Process; Productivity; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Publications; Qualifying; Race; Racial Group; Randomized; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Support; Research, Laboratory; Researchers; Risk; Sampling; Scheme; Scientific Publication; Screening procedure; Services; Site; Socio-economic status; Socioeconomic Status; Source; South America; Southeast Asia; Southeastern Asia; Spanish Origin; Status, Socioeconomic; Stocks, Racial; Study Subject; Study Type; Survey Instrument; Surveys; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Training; Trimester, First; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States; United States National Institutes of Health; Universities; Weight; Wing; Woman; Work; adiposity; age at pregnancy; base; black American; children; clinical care; clinical data repository; clinical data warehouse; clinical investigation; cohort; corpulence; corpulency; corpulentia; data repository; demographics; diagnostic ultrasound; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; enroll; environment effect on gene; environmental risk; experience; fetal medicine; gene environment interaction; genetic determinant; genetic epidemiology; geographic site; heavy metal Pb; heavy metal lead; hispanic community; insight; interventional strategy; intrapartum; intrauterine growth; meetings; member; mitochondrial; mtDNA; novel; obese; obese people; obese person; obese population; ontogeny; oriental; outreach program; parity; pathophysiology; patient population; personnel; phase 1 study; pregnant; premature; premature childbirth; premature delivery; preterm delivery; professor; programs; prospective; public health medicine (field); public health relevance; quality assurance; racial and ethnic; racial/ethnic; randomisation; randomization; randomly assigned; recruit; relational database; screening; screenings; social; sonogram; sonography; sound measurement; study design; ultrasound; ultrasound imaging; ultrasound scanning; working group; youngster",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63046,ZHD1,Special Emphasis Panel,,1,198902,
7791022,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063047-01,,NICHD:199786;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW YORK,UNITED STATES,OBSTETRICS & GYNECOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"WAPNER, RONALD ;",8385906;,1U10HD063047,01/10/2010,12/31/2012,"Birth; Birth of Full-Term Infant; Birth of Full-Term Newborn; Characteristics; Clinical; Clinical Cooperative Groups; Clinical Research; Clinical Study; Clinical Trial Groups; Clinical Trials Cooperative Group; Coupled; Demographic Factors; Development; Diagnosis, Ultrasound; Discipline of obstetrics; Echography; Echotomography; Environmental Exposure; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Fetal Mortality; Fetal Mortality Statistics; Fetus; Fullterm Birth; Generalized Growth; Genetic; Genotype; Gestation; Growth; Healthcare Systems; Incidence; Inflammatory; Infrastructure; Intervention; Intervention Strategies; Lead; Medical Imaging, Ultrasound; Morbidity; Morbidity - disease rate; Obstetrics; Participant; Parturition; Pathology; Pathway interactions; Patients; Pb element; Physiologic; Physiological; Placental Development; Placentation; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Preterm Birth; Prevention; Public Health; Relative; Relative (related person); Research Infrastructure; Risk; Risk Factors; Role; Systems, Health Care; Term Birth; Tissue Growth; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; Woman; cytokine; diagnostic ultrasound; fetal; fetal medicine; genetic epidemiology; heavy metal Pb; heavy metal lead; high risk; interventional strategy; ontogeny; pathway; premature; premature childbirth; premature delivery; preterm delivery; public health medicine (field); public health relevance; response; social role; sonogram; sonography; sound measurement; ultrasound; ultrasound imaging; ultrasound scanning",Prevention of Preterm Birth in high Risk Nulliparous Patients,,63047,ZHD1,Special Emphasis Panel,,1,199786,
7790992,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063048-01,,NICHD:207350;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PHILADELPHIA,UNITED STATES,OBSTETRICS & GYNECOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"PARRY, SAMUEL I.;",1879283;,1U10HD063048,01/10/2010,12/31/2012,"Affect; Angiogenic Factor; Arteries; Assay; Bioassay; Biologic Assays; Biological Assay; Cells; Cervical; Clinical; Clinical Research; Clinical Study; Cohort Studies; Collaborations; Concurrent Studies; Consultations; Data; Data Quality; Diagnosis, Ultrasound; Discipline of obstetrics; Dysfunction; Echography; Echotomography; Enrollment; Environmental Exposure; Factor, Angiogenesis; Functional disorder; Genetic; Genomics; Gestation; Gynecology; HOSP; Health system; High Throughput Assay; Histology; Hospitals; Hospitals, University; Investigators; Label; Laboratory Study; Length; Medical Imaging, Ultrasound; Methods and Techniques; Methods, Other; Neonatal Mortality; Obstetrics; Outcome; Participant; Patient Recruitments; Pennsylvania; Physicians; Physiopathology; Population; Population Study; Pregnancy; Premature Birth; Preterm Birth; Principal Investigator; Proteins; Proteomics; Protocol; Protocols documentation; Publications; Quality, Data; Recruitments, Patient; Research; Research Design; Research Personnel; Researchers; Risk; Risk Factors; Sample Size; Sampling Studies; Scientific Publication; Services; Site; Study Type; Techniques; Testing; Translational Research; Translational Research Enterprise; Translational Science; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; University Hospitals; Woman; biomarker; design; designing; diagnostic ultrasound; enroll; fetal medicine; gene product; high throughput screening; interest; neonatal mortalities; new therapeutics; newborn mortality; next generation therapeutics; novel therapeutics; pathophysiology; premature childbirth; premature delivery; prenatal; preterm delivery; prevent; preventing; prospective; public health relevance; sample collection; sonogram; sonography; sound measurement; specimen collection; study design; transcriptomics; translation research enterprise; ultrasound; ultrasound imaging; ultrasound scanning; unborn",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63048,ZHD1,Special Emphasis Panel,,1,207350,
7791505,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063053-01,,NICHD:193948;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SALT LAKE CITY,UNITED STATES,OBSTETRICS & GYNECOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"SILVER, ROBERT M;",2298784;,1U10HD063053,01/10/2010,12/31/2012,"0-6 weeks old; Accounting; Address; Birth; Cause of Death; Characteristics; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Network; Clinical Trials, Unspecified; Cohort Studies; Communities; Community Hospitals; Concurrent Studies; Discipline of obstetrics; Environmental Exposure; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Fetal Growth; Future; Genetic; Genomics; Gestation; Gestosis, EPH; Growth and Development; Growth and Development function; Growth, Fetal; Gynecology; Health Sciences; History; Hospitals, Community; Image; Individual; Infant, Newborn; Infrastructure; Investigators; Knowledge; Methods; Mortality; Mortality Vital Statistics; NICHD; National Institute of Child Health and Human Development; Newborn Infant; Newborns; Obstetrics; Organization Charts; Outcome; PROV; Parturition; Pathology; Perinatal; Perinatal Epidemiology; Physiologic; Physiological; Placental Development; Placentation; Population; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Preterm Birth; Proteinuria-Edema-Hypertension Gestosis; Proteomics; Protocol; Protocols documentation; Provider; Qualifying; Recording of previous events; Research; Research Infrastructure; Research Personnel; Researchers; Risk; Screening procedure; Stillbirth; Toxemias, Pregnancy; United States; Universities; Utah; Woman; base; clinical investigation; clinical research site; clinical site; design; designing; experience; fetal; fetal medicine; flexibility; health disparities; health disparity; imaging; improved; intrauterine growth; member; multidisciplinary; neonatal morbidity; neonate; newborn human (0-6 weeks); organizational structure; population based; pregnancy toxemia/hypertension; premature childbirth; premature delivery; preterm delivery; prospective; public health relevance; response; screening; screenings; willingness",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63053,ZHD1,Special Emphasis Panel,,1,193948,
7791631,U10,HD,1,,01/10/2010,12/31/2010,HD-08-029,1U10HD063072-01,,NICHD:215459;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CLEVELAND,UNITED STATES,OBSTETRICS & GYNECOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"MERCER, BRIAN M.;",6663945;,1U10HD063072,01/10/2010,12/31/2012,"Active Follow-up; Biologic Characteristic; Biologic Marker; Biological Characteristics; Biological Markers; Care Givers; Caregivers; Caring; Characteristic, Biologic; Clinical; Clinical Research; Clinical Study; Clinical and Translational Science Awards; Collaborations; Data; Diagnosis, Ultrasound; Discipline of obstetrics; Doppler velocimetry; Echography; Echotomography; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Ethnic Origin; Ethnicity; Ethnicity aspects; Faculty; Fetal Growth Restriction; Fetal Growth Retardation; Fetus; Funding; Future; Genomics; Gestation; Gestosis, EPH; HOSP; History; Hospitals; Human Resources; IUGR; Image; Infrastructure; Institution; Intervention; Intervention Strategies; Intrauterine Growth Retardation; Investigators; Knowledge; Leadership; Link; Manpower; Medical Imaging, Ultrasound; Medical center; Mentors; Molecular Marker; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mothers; Multicenter Trials; NICHD; National Institute of Child Health and Human Development; Neonatal; Neonatology; Observational Study; Obstetrics; Ohio; Outcome; Pathology; Patient Care; Patient Care Delivery; Patients; Performance; Perinatal; Perinatal Epidemiology; Physiologic; Physiological; Population; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Preterm Birth; Prevention; Principal Investigator; Procedures; Process; Proteinuria-Edema-Hypertension Gestosis; Proteomics; Publications; Race; Racial Group; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Research Resources; Research Subject Recruitments; Researchers; Resources; Risk; Sampling; Science; Scientific Publication; Signature Molecule; Site; Socio-economic status; Socioeconomic Status; Specialist; Status, Socioeconomic; Stillbirth; Stocks, Racial; Subject Recruitments, Research; Toxemias, Pregnancy; Translational Research; Translational Research Enterprise; Translational Science; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States; Universities; Woman; biomarker; clinical practice; design; designing; diagnostic ultrasound; experience; fetal; fetal medicine; follow-up; genetic epidemiology; high risk; imaging; interest; interventional strategy; intrauterine growth restriction; multidisciplinary; personnel; pregnancy toxemia/hypertension; premature childbirth; premature delivery; prenatal growth disorder; preterm delivery; prevent; preventing; public health relevance; sample collection; sonogram; sonography; sound measurement; specimen collection; success; translation research enterprise; ultrasound; ultrasound imaging; ultrasound scanning",Adverse Outcomes in Nulliparous Pregnancies: The Ohio Collaborative,,63072,ZHD1,Special Emphasis Panel,,1,215459,
7798372,U10,HD,1,,02/01/2010,12/31/2010,HD-09-002,1U10HD063094-01,,NICHD:983372;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"FLOCKHART, DAVID ALASTAIR;",1888575;,1U10HD063094,02/01/2010,12/31/2014,"0-11 years old; 1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT-2A Gene; 5-HT2A; 5-Hydroxytryptamine; 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene; 5-Hydroxytryptamine Receptor 2A Gene; 5HT; 5HT transporter; 5HTT protein; Address; Adverse effects; Affect; Alcohol Drinking; Alcohol consumption; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Bio-Informatics; Biochemical; Bioethics; Bioinformatics; Blood Plasma; Blood Vessels; CP33; CP34; CPC9; CPCJ; CPD6; CYP2C; CYP2C10; CYP2C19; CYP2C19 gene; CYP2C9; CYP2C9 gene; CYP2D; CYP2D6; CYP2D6 gene; CYP2DL1; CYP3; CYP3A; CYP3A13; CYP3A3; CYP3A4; CYP3A4 gene; CYP3A5; CYP3A5 protein, human; CYPIIIA4; CYPIIIA5; Caring; Child; Child Youth; Children (0-21); Clinical; Clinical Pharmacology; Clinical Research; Clinical Study; Data; Data Set; Dataset; Depression; Depression, Postpartum; Development, Infant; Discipline; Discipline of obstetrics; Disease; Disorder; Dose; Drug Kinetics; Drugs; Emotional Depression; Enteramine; Environment; Enzymes; EtOH drinking; Ethics Committees, Research; Ethics, Biomedical; Exposure to; Fetus; Fluoxetin; Fluoxetine; Genes; Genetic Polymorphism; Gestation; Goals; HLP; HTR2; HTR2 Gene; HTR2A; HTR2A gene; Hippophaine; History; Human, Child; IRBs; Incidence; Indiana; Infant; Infant Development; Institutional Review Boards; Intermediary Metabolism; Knowledge; Laboratories; Lead; Life; Link; METBL; Measures; Medication; Mental Depression; Metabolic Processes; Metabolism; Modeling; Mothers; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; NF-25; Neonatal; Neonatology; Obstetrics; Outcome; P450 MP-4; P450 PB-1; P450-DB1; P450-PCN1; P450-PCN3; P450C2C; P450C2D; P450C3; P450IIC19; P450IIC9; P450PCN1; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacogenetics; Pharmacogenomics; Pharmacokinetics; Pharmacology; Pharmacology, Clinical; Plasma; Polymorphism (Genetics); Polymorphism, Genetic; Population; Post-Natal Depression; Post-Partum Depression; Postnatal Depression; Postpartum Depression; Pregnancy; Pregnancy Outcome; Pregnant Women; Prevalence; Principal Investigator; Recording of previous events; Research; Research Design; Research Ethics Committees; Reticuloendothelial System, Serum, Plasma; Risk; SSRI; Safety; Sampling; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Serotonin; Serotonin 5-HT-2 Receptor Gene; Sertraline; Serum, Plasma; Study Type; Symptoms of depression; Technology; Testing; Therapeutic; Therapeutic Studies; Therapy Research; Time; Treatment Side Effects; Woman; Work; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; angiogenesis; base; bear children; bearing children; biomarker; child bearing; childbearing; children; clinical applicability; clinical application; clinical efficacy; coping; cytochrome P-450 CYP3A5; cytochrome P-450 CYP3A5 (human); cytochrome P-450 hPCN3; cytochrome P4503A5; depressed mother; depressive; depressive symptoms; disease/disorder; drug metabolism; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; heavy metal Pb; heavy metal lead; high throughput technology; improved; innovate; innovation; innovative; maternal depression; neonate; new approaches; novel approaches; novel strategies; novel strategy; pathway; pharmacokinetic model; polymorphism; pre-clinical; preclinical; pregnant; serotonin reuptake inhibitor; serotonin transporter; side effect; skills; sodium-dependent serotonin transporter; study design; success; suicidal; therapy adverse effect; treatment adverse effect; vascular; youngster",Indiana PREGMED,,63094,ZHD1,Special Emphasis Panel,,1,983372,
7799565,U13,HD,1,,01/21/2010,12/31/2010,PAR-09-092,1U13HD063139-01,,NICHD:30000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,HONOLULU,UNITED STATES,OTHER HEALTH PROFESSIONS,01,965088057,US,HI,96822,UNIVERSITY OF HAWAII AT MANOA,"QURESHI, KRISTINE ANN (contact);TSE, ALICE ;",8843649 (contact);9827626;,1U13HD063139,01/21/2010,12/31/2012,"0-11 years old; Address; Affect; American; American Samoa; Applications Grants; Area; Armed Forces Personnel; Asia; Care, Health; Child; Child Youth; Childhood; Children (0-21); Collaborations; Commerce; Commerces; Communication; Communities; Community Education; Community Health; Community Health Education; Community Health Taining; Community HealthTutoring; Data; Dental Hygiene; Development; Discipline of Nursing; Disease; Disorder; Eastern Samoa; Education; Educational aspects; Educational workshop; Effectiveness; Employment; Federated States of Micronesia; Fostering; Geography; Goals; Grant; Grant Proposals; Grants, Applications; Guam; Hawaii; Health; Health Education, Community; Health Instruction; Health Promotion; Health Training; Health Tutoring; Health education; Healthcare; Healthy People 2010; Human, Child; Infant Mortality; Infant Mortality Total; Information Dissemination; Institution; Internet; Knowledge; Leadership; Life; Marshall Islands; Mentors; Methods and Techniques; Methods, Other; Military; Military Personnel; Northern Mariana Islands; Nurses; Nursing; Nursing Field; Nursing Profession; Nutrition Disorders; Nutritional Disorders; Obesity; On-Line Systems; Online Systems; Oral; Oral Hygiene; Outcome; Pacific Island Americans; Pacific Islander; Pacific Islander American; Pacific Islands; Palau; Participant; Partner Communications; Personnel, Nursing; Persons; Phone; Population; Postneonatal Mortality; Primary Care; Primary Health Care; Primary Healthcare; Process; Programs (PT); Programs [Publication Type]; QOL; Quality of life; R01 Mechanism; R01 Program; RPG; Research Activity; Research Grants; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Rest; Salutogenesis; School Health Nursing; School Nursing; Series; Social Change; Social modification; Social transformation; Structure; System; System, LOINC Axis 4; Techniques; Technology; Telephone; Trainers Training; Training; Training Programs; Travel; United States; Universities; Videoconference; Videoconferences; Videoconferencing; Videoconferencings; WWW; Work; Workshop; adiposity; base; children; community based participatory research; community organizations; conference; corpulence; corpulency; corpulentia; design; designing; disease prevention; disease/disorder; disorder prevention; health disparities; health disparity; health literacy; improved; meetings; member; obese; obese people; obese person; obese population; online computer; outreach; pediatric; prevent; preventing; prevention service; programs; public health relevance; residence; symposium; web; web based; world wide web; youngster",Community-Based Capacity Building:  Academic-Community Partnerships Using Partici," Project Narrative  The UH SONDH will collaborate with the American Pacific Nursing Leadership Council to implement a project with the overall aim of developing capacity for community based participatory research in the USAPI. The project work will be accomplished through training programs & meetings to be conducted in the USAPI jurisdictions, and culminate in a CBPR grant proposal for the USAPI.",63139,ZHD1,Special Emphasis Panel,,1,30000,
7798683,U13,HD,1,,01/22/2010,12/31/2010,PAR-09-092,1U13HD063168-01,,NICHD:29999;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PHILADELPHIA,UNITED STATES,PHYSICAL MEDICINE & REHAB,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"COOPER, JEFFREY W;SEGAL, MARY E (contact);",1868458 (contact);9730480;,1U13HD063168,01/22/2010,12/31/2012,"0-11 years old; 21+ years old; Academy; Address; Adult; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Awareness; Awarenesses; Care, Health; Cerebral Palsy; Characteristics; Child; Child Development Disorders; Child Youth; Children (0-21); Chronic Disease; Chronic Illness; Collaborations; Communities; Consultations; Development; Developmental Disabilities; Diagnosis; Doctor of Philosophy; Educational workshop; Family Health; Family health status; Funding; Funding Opportunities; General Population; General Public; Goals; Grant; Health; Health Instruction; Health Promotion; Health Training; Health Tutoring; Health education; Health, School; Healthcare; Human, Adult; Human, Child; Institution; Intellectual disability; Intellectual functioning disability; Intellectual limitation; Investigators; Kanner's Syndrome; Knowledge; Lead; Letters; Life; Method LOINC Axis 6; Methodology; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutrition; Nutritional Science; Obesity; Outcome; Over weight; Overweight; Pb element; Pennsylvania; Perception; Persons; Ph.D.; PhD; Population; Prevalence; Principal Investigator; R01 Mechanism; R01 Program; RPG; Research; Research Design; Research Grants; Research Personnel; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk; Risk Factors; Salutogenesis; School-Age Population; Science of nutrition; Series; Stigmata; Study Type; Underserved Population; United States National Institutes of Health; Universities; Weight; Work; Workshop; adiposity; adult human (21+); base; children; chronic disease/disorder; chronic disorder; community based participatory research; community organizations; corpulence; corpulency; corpulentia; experience; fitness; health disparities; health disparity; health literacy; heavy metal Pb; heavy metal lead; improved; interest; meetings; member; nutrition; obese; obese people; obese person; obese population; obesity in children; obesity risk; outreach; peer; public health relevance; school age; school health; social stigma; stigma; study design; under served population; underserved people; youngster",Reducing Obesity Risk in Children with Developmental Disabilities," The purpose of this proposal is to establish a community-based participatory research network spearheaded by local organizations in south central Pennsylvania to decrease the risk of obesity and improve health and wellness of school-age children with developmental disabilities (DD) such as autism and intellectual disabilities. The effort will lead to a self-sustaining collaborative network dedicated to the goal of promoting good health through everyday living for this greatly under-served population. People with many DD have higher rates of obesity and lower fitness than those in the general population, and children with DD are at elevated risk.",63168,ZHD1,Special Emphasis Panel,,1,29999,
7799589,U13,HD,1,,01/18/2010,12/31/2011,PAR-09-092,1U13HD063190-01,,NICHD:30000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,HOUSTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,18,036837920,US,TX,772045037,UNIVERSITY OF HOUSTON,"LEE, REBECCA E;",7952990;,1U13HD063190,01/18/2010,12/31/2013,"0-11 years old; Address; Adoption; Americas; Area; Attention; Body Weight decreased; Brain; Cessation of life; Child; Child Youth; Children (0-21); Cities; Collection; Color; Communities; Community Outreach; Complex; Data; Death; Development; Education; Educational aspects; Educational workshop; Encephalon; Encephalons; Enrollment; Environment; Epidemic; FLR; Failure (biologic function); Fats; Fatty acid glycerol esters; Funding; Goals; Group Meetings; Guidelines; Habits; Health; Health Instruction; Health Training; Health Tutoring; Health education; Human; Human, Child; Human, General; Individual; Internet; Interview; Knowledge; Length of Life; Life Style; Lifestyle; Longevity; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Medical; Meetings, Group; Methods; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, Brain; Newsletter; Obesity; Outreach, Community; Performance; Policies; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Science; Scientist; Sight; Solutions; Structure; Survey Instrument; Surveys; System; System, LOINC Axis 4; Texas; TimeLine; United States National Institutes of Health; Universities; Vision; WWW; Weight Loss; Weight Reduction; Woman; Workshop; adiposity; base; behavior change; body weight loss; children; community based participatory research; conference; corpulence; corpulency; corpulentia; enroll; evidence base; failure; health disparities; health disparity; improved; life span; lifespan; meetings; member; obese; obese people; obese person; obese population; obesity prevention; outreach; programs; public health medicine (field); public health relevance; social; success; symposium; trend; web; web site; world wide web; wt-loss; youngster",Science and Community: Ending Obesity Improving Health," Public Health Significance  Approximately 280,000 deaths and $117 billion in medical expenses are attributed to obesity and obesity-related conditions each year and there is no known sustainable solution. Engaging community members, employing local knowledge, and investing community members from the most vulnerable communities, in the process of research to tackle this health problem through CBPR is highly significant to public health.",63190,ZHD1,Special Emphasis Panel,,1,30000,
7801557,U13,HD,1,,02/01/2010,01/31/2011,PAR-09-092,1U13HD063194-01,,NICHD:30000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW YORK,UNITED STATES,,15,012729476,US,NY,100323729,NEW YORK-PRESBYTERIAN HOSPITAL,"YOUNGE, RICHARD G.;",9852984;,1U13HD063194,02/01/2010,01/31/2013,"Academy; Address; African American; Afro American; Afroamerican; Black Populations; Black or African American; Care, Health; Catchment Area; Collaborations; Communities; Community Health; Community Outreach; Community Participation; Feedback; Focus Groups; Funding; Future; HOSP; Health; Health Care Research; Health Resources; Health Services Evaluation; Health Services Research; Health Status; Healthcare; Healthcare Research; Height; Hospitals; Hospitals, University; Information Dissemination; Institution; Intervention; Intervention Strategies; Latino; Level of Health; Life; Medical Care Research; Neighborhoods; New York; Organization Charts; Outcome; Outcome Assessment (Health Care); Outcome Measure; Outcomes Assessment; Outreach, Community; Participation, Community; Population; Presbyterian Church; Presbyterians; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Role; Schools; Structure; Trust; Universities; University Hospitals; Washington; Work; base; black American; community based participatory research; community organizations; design; designing; health disparities; health disparity; health literacy; high school; improved; interest; interventional strategy; organizational structure; public health relevance; services research; social role; tool",Lower Washington Heights CBPR Partnership," Our hypothesis is that a strong pre-existing partnership of invested community organizations aligned with a research team based at the institutions surrounding the catchment area, and the use of Community Based Participatory Research can coalesce as an effective tool for change - both locally and, by extension, nationally.",63194,ZHD1,Special Emphasis Panel,,1,30000,
8014670,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009002-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,MONTGOMERY,UNITED STATES,,03,613842061,US,AL,361303017,ALABAMA STATE DEPT OF PUBLIC HEALTH,"WILLIAMSON, DONALD E;",10378514;,2B01DP009002,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9002,ZDP1,Special Emphasis Panel,,10,402948,
8014671,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009003-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,LITTLE ROCK,UNITED STATES,,02,,US,AR,72205,ARKANSAS STATE DEPT OF HEALTH,"HALVERSON, PAUL ;",10378519;,2B01DP009003,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9003,ZDP1,Special Emphasis Panel,,10,453640,
8014674,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009006-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,SACRAMENTO,UNITED STATES,,01,,US,CA,958997413,CALIFORNIA ST DEPT OF HLTH SRVS-SACRAMEN,"SHREWRY, SANDRA ;",9759793;,2B01DP009006,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9006,ZDP1,Special Emphasis Panel,,10,3513110,
8014675,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009007-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,DENVER,UNITED STATES,,01,878208826,US,CO,802461530,COLORADO STATE DEPT/PUB HLTH & ENVIRONMT,"ELLIS, DENNIS ;",10378541;,2B01DP009007,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9007,ZDP1,Special Emphasis Panel,,10,629232,
8014676,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009008-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,HARTFORD,UNITED STATES,,01,807853791,US,CT,061061367,CONNECTICUT STATE DEPT OF PUBLIC HEALTH,"GALVIN, J. R;",10378546;,2B01DP009008,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9008,ZDP1,Special Emphasis Panel,,10,734218,
8014679,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009011-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,TALLAHASSEE,UNITED STATES,,02,364215061,US,FL,32399,FLORIDA STATE DEPARTMENT OF HEALTH,"SORENSEN, BONITA ;",10378561;,2B01DP009011,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9011,ZDP1,Special Emphasis Panel,,10,1533964,
8014680,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009012-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,POHNPEI,FED MICRONESIA,,,,,,,FEDERATED STATES MICRONESIA,"NENA, NENA S;",10378566;,2B01DP009012,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9012,ZDP1,Special Emphasis Panel,,10,32500,
8014685,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009017-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,BOISE,UNITED STATES,,02,825201486,US,ID,837200036,IDAHO STATE DEPT OF HEALTH AND WELFARE,"SCHULTZ, RICHARD H;",10378591;,2B01DP009017,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9017,ZDP1,Special Emphasis Panel,,10,94245,
8014687,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009019-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,INDIANAPOLIS,UNITED STATES,,07,824799407,US,IN,46204,INDIANA STATE DEPARTMENT OF HEALTH,"BAILEY, JOHN C;",10378601;,2B01DP009019,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9019,ZDP1,Special Emphasis Panel,,10,427785,
8014692,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009024-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,BOSTON,UNITED STATES,,09,878298900,US,MA,021084619,MASSACHUSETTS STATE DEPT OF PUB HEALTH,"COTE, PAUL ;",10378626;,2B01DP009024,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9024,ZDP1,Special Emphasis Panel,,10,1374800,
8014694,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009026-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,AUGUSTA,UNITED STATES,,01,809045594,US,ME,04333,MAINE STATE DEPT/HEALTH/HUMAN SERVS,"MILLS, DORA ANN ;",10378636;,2B01DP009026,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9026,ZDP1,Special Emphasis Panel,,10,450465,
8014697,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009029-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,ST. PAUL,UNITED STATES,,04,804887321,US,MN,551640975,MINNESOTA STATE DEPT OF HEALTH,"MANDERNACH, DIANNE ;",10378651;,2B01DP009029,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9029,ZDP1,Special Emphasis Panel,,10,1277476,
8014702,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009034-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,RALEIGH,UNITED STATES,,02,809785363,US,NC,27603,NC STATE DEPT/HLTH & HUMAN SERVICES,"DEVLIN, LEAH ;",10378675;,2B01DP009034,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9034,ZDP1,Special Emphasis Panel,,10,1390276,
8014703,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009035-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,BISMARCK,UNITED STATES,,00,067976824,US,ND,585050200,NORTH DAKOTA STATE DEPARTMENT OF HEALTH,"DWELLE, TERRY ;",10378680;,2B01DP009035,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9035,ZDP1,Special Emphasis Panel,,10,129386,
8014707,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009039-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,SANTA FE,UNITED STATES,,03,808389274,US,NM,87505,NEW MEXICO STATE DEPARTMENT OF HEALTH,"VALDEZ, J A;",10378700;,2B01DP009039,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9039,ZDP1,Special Emphasis Panel,,10,706814,
8014708,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009040-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,CARSON CITY,UNITED STATES,,02,809888266,US,NV,897062009,NEVADA STATE DEPT OF HLTH/HUMAN SVCS,"HAARTZ, ALEX ;",10378705;,2B01DP009040,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9040,ZDP1,Special Emphasis Panel,,10,199400,
8014709,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009041-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,MENANDS,UNITED STATES,,21,002436061,US,NY,122042719,NEW YORK STATE DEPT OF HEALTH,"ALFIE, ADELA SALAME;",10380151;,2B01DP009041,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9041,ZDP1,Special Emphasis Panel,,10,3493688,
8014710,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009042-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,COLUMBUS,UNITED STATES,,15,808847933,US,OH,43215,OHIO STATE DEPARTMENT OF HEALTH,"BAIRD, J N;",10378715;,2B01DP009042,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9042,ZDP1,Special Emphasis Panel,,10,2294984,
8014713,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009045-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,HARRISBURG,UNITED STATES,,17,614489839,US,PA,171200701,PENNSYLVANIA STATE DEPT OF HEALTH,"JOHNSON, CALVIN B;",10378730;,2B01DP009045,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9045,ZDP1,Special Emphasis Panel,,10,2418352,
8014717,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009049-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,COLUMBIA,UNITED STATES,,06,808385892,US,SC,292011708,SOUTH CAROLINA STATE DEPT OF HLTH/ENV,"HUNTER, EARL ;",10378750;,2B01DP009049,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9049,ZDP1,Special Emphasis Panel,,10,624526,
8014721,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009053-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,AUSTIN,UNITED STATES,,10,,US,TX,787563199,TEXAS STATE DEPARTMENT OF HEALTH SRVS,"SANCHEZ, EDUARDO J;",10378770;,2B01DP009053,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9053,ZDP1,Special Emphasis Panel,,10,2082676,
8014723,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009055-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,RICHMOND,UNITED STATES,,03,787082825,US,VA,23218,VIRGINIA STATE DEPT OF HEALTH,"STROUBE, ROBERT ;",10378780;,2B01DP009055,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9055,ZDP1,Special Emphasis Panel,,10,1036159,
8014726,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009058-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,OLYMPIA,UNITED STATES,,03,127347115,US,WA,985045330,WASHINGTON STATE DEPART SOC/HLTH SRVS,"HAYNES, MAXINE ;",9760051;,2B01DP009058,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9058,ZDP1,Special Emphasis Panel,,10,518656,
8014727,B01,DP,2,,10/01/2009,09/30/2011,,2B01DP009059-10,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,MADISON,UNITED STATES,,02,036448835,US,WI,537077850,WISCONSIN STATE DEPT OF HLTH/FAMILY SVC,"JOHNSON, SHERI L;",9655427;,2B01DP009059,10/01/2009,09/30/2011,,PREVENTIVE HEALTH SERVICES,,9059,ZDP1,Special Emphasis Panel,,10,992424,
7992254,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010007-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,HARTFORD,UNITED STATES,,01,103626086,US,CT,06134,CONNECTICUT ST DEPT OF MH/ADDICTION SRVS,"REHMER, PATRICIA ;",10376484;,2B08TI010007,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10007,ZTI1,Special Emphasis Panel,,10,8535544,
7992263,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010018-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,CHICAGO,UNITED STATES,,07,,US,IL,60601,ILLINOIS DEPT OF HUMAN SERVICES,"BINION-TAYLOR, THEODORA ;",10322064;,2B08TI010018,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10018,ZTI1,Special Emphasis Panel,,10,35057358,
7992265,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010020-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,TOPEKA,UNITED STATES,,02,175937804,US,KS,666121570,KANSAS STATE DEPT/ SOCIAL/ REHAB/ SRVS,"STIDHAM, DEBORAH ;",10372832;,2B08TI010020,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10020,ZTI1,Special Emphasis Panel,,10,6166989,
7992267,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010022-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,BATON ROUGE,UNITED STATES,,04,,US,LA,70821,STATE OF LOUISIANA,"DUFFY, MICHAEL ;",10322076;,2B08TI010022,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10022,ZTI1,Special Emphasis Panel,,10,12969924,
7992268,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010023-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,BOSTON,UNITED STATES,,09,,US,MA,021084603,MASSACHUSETTS STATE DEPT OF PUBLIC HLTH,"BOTTICELLI, MICHAEL P;",10322079;,2B08TI010023,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10023,ZTI1,Special Emphasis Panel,,10,17225986,
7992271,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010026-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,LANSING,UNITED STATES,,07,113704139,US,MI,48913,MICHIGAN STATE DEPT OF COMMUNITY HEALTH,"OLSZEWSKI, JANET ;",10322088;,2B08TI010026,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10026,ZTI1,Special Emphasis Panel,,10,29049337,
7992279,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010034-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,LINCOLN,UNITED STATES,,01,808819957,US,NE,685095026,NEBRASKA ST DEPT OF HEALTH & HUMAN SERVS,"ADAMS, SCOT ;",10330922;,2B08TI010034,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10034,ZTI1,Special Emphasis Panel,,10,3960066,
7992285,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010040-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,ALBANY,UNITED STATES,,21,,US,NY,122033526,NEW YORK STATE OFF/ALCOH & SUBST ABUSE,"CARPENTER-PALUMBO, KAREN ;",10322130;,2B08TI010040,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10040,ZTI1,Special Emphasis Panel,,10,57955820,
7992287,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010042-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,OKLAHOMA CITY,UNITED STATES,,06,933662934,US,OK,73152,OKLAHOMA DEPT OF MENTAL HLTH/SUBS ABUSE,"WHITE, TERRI ;",10372801;,2B08TI010042,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10042,ZTI1,Special Emphasis Panel,,10,8887630,
7992294,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010049-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,PIERRE,UNITED STATES,,00,,US,SD,57501,SOUTH DAKOTA STATE DEPT OF HUMAN SRVS,"SUDBECK, GILBERT ;",10322157;,2B08TI010049,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10049,ZTI1,Special Emphasis Panel,,10,2543397,
7992296,B08,TI,2,,10/01/2009,09/30/2011,,2B08TI010051-10,,CSAT:;,2010,Center for Substance Abuse Treatment,,AUSTIN,UNITED STATES,,10,807391511,US,TX,78756,TEXAS STATE DEPT OF HEALTH SERVICES,"MAPLES, MIKE ;",10322163;,2B08TI010051,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10051,ZTI1,Special Emphasis Panel,,10,68228090,
7995854,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010002-10,,CMHS:;,2010,Center for Mental Health Services,,PAGO PAGO,UNITED STATES,,,,US,AS,96799,DEPARTMENT OF HUMAN AND SOCIAL SERVICES,"STEVENSON, LEILUA ;",10373899;,2B09SM010002,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10002,ZSM1,Special Emphasis Panel,,10,42209,
7995860,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010008-10,,CMHS:;,2010,Center for Mental Health Services,,WASHINGTON,UNITED STATES,,00,,US,DC,20002,DISTRICT OF COLUMBIA DEPT OF MENTAL HLTH,"BARON, STEPHEN T;",10330823;,2B09SM010008,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10008,ZSM1,Special Emphasis Panel,,10,386482,
7995861,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010009-10,,CMHS:;,2010,Center for Mental Health Services,,NEW CASTLE,UNITED STATES,,00,,US,DE,19720,DELAWARE STATE DEPT OF HLTH & SOC SRVS,"LANDGRAF, RITA ;",10374540;,2B09SM010009,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10009,ZSM1,Special Emphasis Panel,,10,365447,
7995864,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010014-10,,CMHS:;,2010,Center for Mental Health Services,,TAMUNING,UNITED STATES,,,,US,GU,96913,GUAM DEPT OF MENTAL HLTH/SUBSTANCE ABUSE,"SHIMIZU, DAVID ;",10374456;,2B09SM010014,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10014,ZSM1,Special Emphasis Panel,,10,114514,
7995876,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010026-10,,CMHS:;,2010,Center for Mental Health Services,,LANSING,UNITED STATES,,07,113704139,US,MI,48913,MICHIGAN STATE DEPT OF COMMUNITY HEALTH,"KAZIECZKO, IRENE ;",10330890;,2B09SM010026,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10026,ZSM1,Special Emphasis Panel,,10,6405007,
7995910,B09,SM,2,,10/01/2009,09/30/2011,,2B09SM010061-10,,CMHS:;,2010,Center for Mental Health Services,,ATLANTA,UNITED STATES,,05,,US,GA,303032117,GEORGIA/BEHAVIORAL/HLTH/DEVELOP/DISABILI,"SHELP, FRANK E;",10331026;,2B09SM010061,10/01/2009,09/30/2011,,Block Grants for Community Mental Health Services,,10061,ZSM1,Special Emphasis Panel,,10,6570849,
7759269,P01,HL,2,,02/01/2010,01/31/2011,,2P01HL076491-06A1,,NHLBI:1946679;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"HAZEN, STANLEY L;",1928715;,2P01HL076491,04/01/2004,01/31/2015,,Oxidation in Inflammation and Cardiovascular Disease,,76491,HLBP,"Heart, Lung, and Blood Program Project Review Committee",A1,6,1946679,
7700413,P41,RR,2,,01/15/2010,12/31/2010,,2P41RR002250-25,,NCRR:1900000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,HOUSTON,UNITED STATES,PHYSIOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"CHIU, WAH ;",7357729;,2P41RR002250,12/01/1996,12/31/2014,,3 D Electron Microscopy of Macromolecules,"Our proposed cryo-EM methodology is targeted to study structures of biologically active nanomachines  which are potential drug targets for treating or preventing diseases. Our collaborative research covers  nanomachines closely tied to infectious diseases (viruses, bacteria and parasite), neurodegenerative  diseases and aging (molecular chaperonins), cancer (complex involving cellular processes and signaling),  and cardiovascular diseases (lipoprotein, blood clotting factors and ion channels).",2250,ZRG1,Special Emphasis Panel,,25,1900000,
7763464,P50,NS,2,,01/18/2010,12/31/2010,,2P50NS038667-11,,NINDS:1048242;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RANSOHOFF, RICHARD M;",1864157;,2P50NS038667,12/01/1999,12/31/2014,,Tissue injury and inflammation in MS (P50),,38667,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,11,1048242,
7837766,P50,NS,2,,,,,2P50NS038667-11,5116,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RANSOHOFF, RICHARD M;",1864157;,2P50NS038667,,,"ATGN; Address; Animal Model; Animal Models and Related Studies; Antigenic Determinants; Antigens; Apoptosis; Apoptosis Pathway; B blood cells; B-Cells; B-Lymphocytes; BLR1; BLR1 gene; BN-1 Gene; BONZO; Binding Determinants; Biopsy; Blood - brain barrier anatomy; Blood leukocyte; Blood monocyte; Blood-Brain Barrier; Body Tissues; Bp50; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-C CKR-5 Gene; C-C CKR-6 Gene; C-C Chemokine Receptor Type 5 Gene; C-C Chemokine Receptor Type 6 Gene; CC-CKR-5 Gene; CC-CKR-6 Gene; CCCKR5 Gene; CCR-5 Gene; CCR-6 Gene; CCR5; CCR5 gene; CCR6; CCR6 gene; CD183; CD195 Antigen Gene; CD40; CDW40; CHEMR13 Gene; CKR-5 Gene; CKR-L2; CKR-L3 Gene; CKR5 Gene; CKR6 Gene; CKRL3 Gene; CMKAR3; CMKBR5 Gene; CMKBR6 Gene; CXCR-5; CXCR3; CXCR3 gene; CXCR5; CXCR6; CXCR6 gene; Cell Death, Programmed; Cells; Cervical Lymph Node; Cervical lymph node group; Chemokine (C-C) Receptor 5 Gene; Chemokine (C-C) Receptor 6 Gene; Chemokine Receptor-Like 3 Gene; Chronic; Collaborations; Competence; Cytokines, Chemotactic; DCR2 Gene; DRY-6 Gene; DRY6 Gene; Data; Demyelinations; Diffuse; Disease; Disorder; Elements; Epitopes; Event; G Protein-Coupled Receptor 29 Gene; GPR-CY4 Gene; GPR29 Gene; GPR9; GPRCY4 Gene; HIV-1 Fusion Co-Receptor Gene; Hemato-Encephalic Barrier; Homologous Chemotactic Cytokines; INFLM; IP10; IP10-R; In Vitro; Infiltration; Inflammation; Inflammatory; Injury; Intercrines; LARC Receptor Gene; Lesion; Leukocyte Trafficking; Leukocytes; Lymph node proper; Lymphoid Follicle; MDR15; MGC9013; MHC Receptor; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Major Histocompatibility Complex Receptor; Marrow leukocyte; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Memory; Meningeal; Meninges; Mig-R; MigR; Modeling; Mononuclear; Myelin; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Pathogenesis; Pathology; Pathway interactions; Performance; Phenotype; Process; Publishing; Receptors, Antigen, T-Cell; Regulation; Reporting; Research; Research Support; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Lymph Node; Role; SIS cytokines; STRL22 Gene; STRL33; Seven-Transmembrane Receptor, Lymphocyte, 22 Gene; Subarachnoid Space; T memory cell; T-Cell Receptor; T-Cells; T-Lymphocyte; TNFRSF5; TNFRSF5 gene; TYMSTR; Thymus-Dependent Lymphocytes; Tissues; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; White Blood Cells; White Cell; Work; Zeugmatography; base; chemoattractant cytokine; chemokine; chemokine receptor; disease/disorder; gray matter; immunogen; in vitro Model; lymph gland; lymph nodes; macrophage; memory T lymphocyte; model organism; monocyte; novel; p50; pathway; social role; substantia alba; substantia grisea; therapeutic target; thymus derived lymphocyte; trafficking; white blood cell; white blood corpuscle; white matter; white matter change",Cortical Demyelination Early In MS,,38667,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,11,,142479
7837767,P50,NS,2,,,,,2P50NS038667-11,5117,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"TRAPP, BRUCE D;",2108918;,2P50NS038667,,,"21+ years old; Adult; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Autopsy; Brain; CD44; CD44 gene; Cell Death; Cell Death, Programmed; Cell Density; Cell Differentiation; Cell Differentiation process; Cell-Extracellular Matrix; Central Nervous System; Cerebral cortex; Chronic; Data; Demyelinations; Development; Disease; Disorder; ECM; Encephalon; Encephalons; Extracellular Matrix; Future; Generations; Goals; Gray; Gray unit of radiation dose; Human, Adult; Hyaluronan; Lesion; Life; Location; M Phase; M phase (cell cycle); MDU3; MS (Multiple Sclerosis); MS Lesions; Mitosis; Mitosis Stage; Molecular; Molecular Target; Morphology; Mother Cells; Multiple Sclerosis; Multiple Sclerosis Lesions; Myelin; Nervous System, Brain; Nervous System, CNS; Neuraxis; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Pathology; Patients; Pattern; Pgp1; Phenotype; Play; Process; Production; Progenitor Cells; QOL; Quality of life; Ranvier's Nodes; Receptor Protein; Rodent Model; Role; Sclerosis, Disseminated; Source; Stem cells; Therapeutic; adult human (21+); base; combinatorial; density; design; designing; disease/disorder; improved; inhibitor; inhibitor/antagonist; insular sclerosis; molecular phenotype; myelination; necrocytosis; necropsy; novel; novel therapeutic intervention; postmortem; receptor; repair; repaired; social role; substantia alba; success; therapeutic target; transcription factor; white matter",Cellular and Molecular Mechanisms of Cortical Remyelination in MS Patients,"This project is designed to further enhance our understanding of the two major cortical lesion patterns of multiple sclerosis. We will characterize successful and failed myelin repair of multiple sclerosis brains, leading to valuable information about disease pathology as well as identification of novel therapeutic approaches to repair the damage and improve the lives of patients with multiple sclerosis.",38667,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,11,,318115
7837768,P50,NS,2,,,,,2P50NS038667-11,5118,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"FISHER, ELIZABETH ;",7944524;,2P50NS038667,,,"Address; Affect; Anatomic; Anatomical Sciences; Anatomy; Atrophic; Atrophy; Body Tissues; Brain; Characteristics; Classification; Clinical; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Correlation Studies; Data; Data Correlations; Data Set; Dataset; Demyelinations; Deterioration; Diffuse; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disease Progression; Disorder; Distant; Disturbance in cognition; Encephalon; Encephalons; Evaluation; Evolution; Follow-Up Studies; Followup Studies; Hand; Heterogeneity; Image; Image Analyses; Image Analysis; Impaired cognition; Injury; Label; Lead; Learning; Lesion; Life; Longitudinal Studies; MR Imaging; MR Tomography; MRI; MS (Multiple Sclerosis); Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Monitor; Multiple Sclerosis; NMR Imaging; NMR Tomography; Nerve Degeneration; Nervous System, Brain; Neuron Degeneration; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Outcome; Pathologic; Pathology; Patient Monitoring; Patients; Pb element; Process; ROC Analysis; Relative; Relative (related person); Role; SUBGP; Science of Anatomy; Sclerosis, Disseminated; Secondary to; Staging; Statistical Correlation; Structure; Subgroup; Systematics; Techniques; Testing; Thick; Thickness; Time; Tissues; Validation; Zeugmatography; anatomy; base; brain tissue; clinical significance; clinically significant; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; diffusion tensor imaging; disability; disease/disorder; gray matter; heavy metal Pb; heavy metal lead; image evaluation; imaging; imaging modality; improved; in vivo; insight; insular sclerosis; long-term study; neural degeneration; neurodegeneration; neuron cell death; neuron loss; neuronal cell death; neuronal degeneration; neuronal loss; novel marker; social role; substantia alba; substantia grisea; tool; white matter",Gray Matter Atrophy in Multiple Sclerosis,"Multiple sclerosis affects the gray matter as much as the white matter in the brain. MRI is commonly used to monitor MS patients, but it is insensitive to most gray matter tissue damage. This study will develop and validate new MRI markers of GM pathology in order to provide a more complete picture of the disease. MRI-based measurements of GM tissue damage will lead to a better understanding of MS and improved tools for monitoring MS patients and for evaluating potential neuroprotective therapies.",38667,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,11,,304490
7837770,P50,NS,2,,,,,2P50NS038667-11,5120,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RANSOHOFF, RICHARD M;",1864157;,2P50NS038667,,,"Advisory Committees; Analysis, Data; Autopsy; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Body Tissues; Bp50; Brain; Budgets; CD40; CDW40; Cephalic; Cessation of life; Clinic; Cranial; Data; Data Analyses; Data Banks; Data Bases; Data Files; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Diagnosis; Encephalon; Encephalons; Ensure; Histology; Image; Imaging Procedures; Imaging Techniques; Investigators; Lesion; MGC9013; MR Imaging; MR Tomography; MRI; MRI Scans; MS Lesions; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Multiple Sclerosis Lesions; NMR Imaging; NMR Tomography; Nervous System, Brain; Notification; Nuclear Magnetic Resonance Imaging; Preparation; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Reporting; Research; Research Activity; Research Design; Research Personnel; Researchers; Spinal Cord; Study Type; TNFRSF5; TNFRSF5 gene; Task Forces; Technics, Imaging; Tissue Donations; Tissue Donors; Tissues; Transportation; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Zeugmatography; clinical data repository; clinical data warehouse; data repository; design; designing; disease characteristic; human tissue; imaging; improved; meetings; necropsy; p50; postmortem; programs; relational database; statistics/biometry; study design; success","Tissue Acquisition, Imaging, Biostatistics, Administration Core","The Core is critical for the success of the P50 projects. The Tissue Acquisition and Characterization unit is a unique program that enables brain and spinal cord tissue donation. The tissues and images that are made available through this program are highly valuable for MS research. The projects also depend heavily on expert biostatistical support, as well as the database, MRI, and administrative support provided by the Core.",38667,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,11,,283158
7780294,R01,AG,2,,02/01/2010,01/31/2011,PA-07-070,2R01AG015339-11A1,,NIA:426463;,2010,NATIONAL INSTITUTE ON AGING,,CAMBRIDGE,UNITED STATES,BIOLOGY,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"GUARENTE, LEONARD P;",1883577;,2R01AG015339,05/01/1999,01/31/2015,"Adipocytes; Adipose Cell; Adipose Tissue, Brown; Affect; Aging; Body Tissues; Bone; Bone Density; Bone Formation; Bone Mineral Density; Bone and Bones; Bones and Bone Tissue; Brain; Brown Fat; Caloric Restriction; Cells; Disease; Disorder; Encephalon; Encephalons; Fat Cells; Grant; Heart; Hibernating Gland; Immune; Immune Function, Cellular; Knockout Mice; Length of Life; Lipocytes; Longevity; Lower Organism; Mammals, Mice; Mature Lipocyte; Mature fat cell; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Myocardium; NADH; Nervous System, Brain; Null Mouse; Osteoblasts; Osteoclasts; Osteogenesis; Role; Senescence; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirtuins; Skeletal Muscle Tissue; Skeletal muscle structure; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; Tissues; bone; calorie restriction; cardiac muscle; cell type; disease/disorder; heart muscle; immune function; life span; lifespan; normal aging; public health relevance; senescent; social role; thymus derived lymphocyte",Function of Mammalian SIRT1 in Aging," Project Narrative Sirtuins regulate life span in lower organisms and may mediate some of the effects of calorie restriction. We plan to determine the functions of mammalian sirtuins, with emphasis on SIRT1, in multiple cell types in mice. These studies may suggest new strategies to treat diseases of aging.",15339,CMAD,Cellular Mechanisms in Aging and Development Study Section,A1,11,426463,
7890682,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI014032-29A2,,NIAID:360000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"FORD, HENRI R;",6424003;,2R01AI014032,12/01/1987,01/31/2015,"ATGN; ATP[{..}]myosin-light-chain O-phosphotransferase; Actomyosin; Acute; Affect; Alimentary Canal; Anabolism; Antigens; Antimorphic mutation; Assay; Bacteria; Bioassay; Biologic Assays; Biological Assay; COX-2 protein; COX2; COX2 enzyme; COX2 inhibitor; CSBP1; CSBP2; CSPB1; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Circulatory Collapse; Coxibs; Critical Illness; Critically Ill; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Digestive Tract; Dinoprostone; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; EC 2.7; EC 2.7.1.117; EP1 receptor; EP1 receptor gene product; EXIP; Electrical Resistance; Enterocytes; Enzymes; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Event; FLR; Failure (biologic function); Fever; Functional disorder; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Goals; Gut Inflammation; Hemorrhagic Shock; Hyperthermia; INFLM; IP3R; IP3R1; ITPR1; ITPR1 gene; Impairment; In Vitro; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Insp3r1; Intestinal; Intestinal Inflammation; Intestinal Mucosa; Intestines; Intracellular Communication and Signaling; Kinases; Lead; Lecithinase C; Lecithinases; MAPK14; MAPK14 gene; MLCK; MOF syndrome; MTGN; MYLK; MYLK2; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Microbe; Mitogens; Molecular; Multiple Organ Failure; Murine; Mus; Mxi2; Myosin Kinase; Myosin LCK; Myosin Light Chain Kinase; Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes; Myosin Light Polypeptide Kinase; Myosin Regulatory Light-Chain Kinase; Myosin light chain kinase 2, skeletal/cardiac muscle; Occluding Junctions; Operation; Operative Procedures; Operative Surgical Procedures; Organ Dysfunction Syndrome, Multiple; PGE1 receptor; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PKC; PRKM14; PRKM15; PTGS2; Pain; Painful; Pathogenesis; Patients; Pb element; Peritonitis; Permeability; Phospholipase; Phospholipase C; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphotransferases; Physiopathology; Process; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; Protein Kinase C; Protein Phosphorylation; Pyrexia; Resistance, Electric; Resuscitation; Role; SAPK2A; Sepsis; Shock; Shock, Hemorrhagic; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Structure of intestinal epithelium; Surgical; Surgical Interventions; Surgical Procedure; Testing; Tight Junctions; Transphosphorylases; Vascular blood supply; Zonula Occludens; alimentary tract; biological signal transduction; biosynthesis; blood supply; bloodstream infection; bowel; circulatory shock; cyclo-oxygenase II; cyclooxygenase 2; design; designing; digestive canal; disease/disorder; failure; febrile; febris; heavy metal Pb; heavy metal lead; immunogen; in vivo; inhibitor; inhibitor/antagonist; insight; intestinal epithelium; lipophosphodiesterase I; monolayer; multiple organ system failure; novel; overexpression; p38; p38 MAPK Gene; p38Alpha; pathogen; pathophysiology; phosphatidylcholine cholinephosphohydrolase; prevent; preventing; prostaglandin H synthase-2; prostanoid receptor EP1; public health relevance; response; seal; smooth muscle myosin light chain kinase; social role; surgery; surgical research; vascular supply",Pathogenesis and Treatment of Experimental Peritonitis," Project Narrative Gut barrier failure affects hundreds of thousands of patients with a variety of acute and chronic inflammatory disorders. Barrier support treatments cannot be developed without understanding the mechanisms of inflammatory gut barrier failure. We propose to elucidate the role of inflammatory prostaglandin E2 (PGE2) in barrier dysfunction during experimental peritonitis. Results of this study will help to design new barrier maintenance under conditions of peritonitis, shock, and sepsis.",14032,SAT,"Surgery, Anesthesiology and Trauma Study Section",A2,29,360000,
7889399,R01,AI,2,,03/01/2010,02/28/2011,PA-07-070,2R01AI018306-27,,NIAID:367723;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ITHACA,UNITED STATES,CHEMISTRY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"BAIRD, BARBARA A;",1903109;,2R01AI018306,08/01/1981,02/28/2015,"2-dimensional; ATGN; Actins; Affect; Affinity; Allergic; Allergic Disease; Analysis, Data; Antigens; Assay; B blood cells; B-Cells; B-Lymphocytes; Basal Cell; Basophilic Histiocyte; Basophils, Tissue; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD 23 Antigens; CD23 Antigens; Cancers; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Membrane Lipids; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular biology; Chemicals; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clathrin; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Data Analyses; Dephosphin; Dimensions; Disease; Disorder; Dynamin; EC 2.7; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Environment; Eukaryote; Eukaryotic Cell; Event; Extracellular Matrix, Integrins; FRET; Family; Fluorescence; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; Goals; Health; IgE; IgE Receptors; Image; Immune; Immune response; Immunoglobulin E; Immunoglobulin E Receptor; Individual; Infection; Integrins; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Kinases; Label; Length; Life; Lipid Rafts, Cell Membrane; Lipids; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Neoplasms; Malignant Tumor; Marrow Mast Cell; Measurable; Measurement; Measures; Mediating; Medical; Membrane; Membrane Lipids; Membrane Microdomains; Membrane Proteins; Membrane-Associated Proteins; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Model System; Models, Biologic; Modification; Molecular; Molecular Interaction; Monitor; Nerve Degeneration; Neuron Degeneration; Optics; Paramagnetic Resonance; Pattern; Phagocytosis; Phagosomes; Phase; Phosphatides; Phospholipids; Phosphotransferases; Plasma Membrane; Play; Polymers; Process; Property; Property, LOINC Axis 2; Proteins; Public Health; Racial Segregation; Receptor Protein; Receptors, Antigen, T-Cell; Receptors, IgE; Regulation; Research; Resolution; Role; Scheme; Signal Transduction; Signal Transduction Systems; Signaling; Spectroscopy; Spectroscopy, ESR; Spectrum Analyses; Spectrum Analysis; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Spin Labels; Stimulus; Structure; Structure-Activity Relationship; Subcellular Process; Surface; Surface Proteins; T-Cell Receptor; Techniques; Testing; Therapeutic; Time; Transphosphorylases; Work; antigen binding; base; biological signal transduction; cell biology; chemical structure function; cholesterol analog; computerized data processing; cross-link; crosslink; data processing; disease/disorder; electron paramagnetic resonance spectroscopy; epsilon Fc Receptors; eukaryotida; experiment; experimental research; experimental study; gene product; host response; imaging; immunogen; immunoresponse; insight; interventional strategy; intracellular skeleton; knock-down; lipid raft; malignancy; mast cell; mastocyte; membrane assembly; membrane structure; nano meter; nano meter scale; nano meter sized; nano pattern; nano scale; nanometer; nanometer scale; nanometer sized; nanopattern; nanoscale; neoplasm/cancer; neural degeneration; neurodegeneration; neuronal degeneration; new approaches; novel approaches; novel strategies; novel strategy; particle; photo switch; physical property; plasmalemma; public health medicine (field); public health relevance; receptor; receptor-mediated signaling; research study; response; segregation; signal processing; social role; structure function relationship; two-dimensional",Structure-Function Relationships of Immunoreceptors," Relevance to Public Health  The heterogeneous plasma membrane millieu of eukaryotic cells maintains a steady state of protein and lipid interactions that support basal cell function and, while serving as a selective barrier, is poised to respond to environmental stimuli. Hijacking or disrupting these highly orchestrated membrane interactions is involved in numerous disease states, including pathogenic infection, neurodegeneration, and some cancers. In recent years the intricate participation of the plasma membrane in spatially regulating receptor-mediated signaling events has become increasingly appreciated. A prominent example is the receptor for IgE, Fc¨RI, on mast cells, which plays a central role in the allergic immune response. The immediate goal of our studies is molecular level elucidation of the structural interactions occurring within dynamic plasma membrane domains that are altered by antigen crosslinking of IgE-Fc¨RI and result in transmembrane triggering of the intracellular signaling cascade and immune cell responses. More generally, a detailed characterization of plasma membrane participation in cellular responses will provide new opportunities for intervention in therapeutic applications and a clearer understanding of the cell biology of health and disease.",18306,BBM,Biochemistry and Biophysics of Membranes Study Section,,27,367723,
7861844,R01,AI,2,,01/15/2010,12/31/2010,PA-07-070,2R01AI031088-15A1,,NIAID:336798;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"ARMSTRONG, SANDRA KAY;",1885944;,2R01AI031088,08/01/1991,11/30/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; ATP phosphohydrolase; ATPase; Abscission; Adenosine Triphosphatase; Adenosinetriphosphatase; Adrenodoxin Reductase; Assimilation; Assimilations; Bacteria; Benzamide, N,N',N''-(2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl)tris(2,3-dihydroxy-, (3S-(3R*,7R*,11R*)))-; Binding; Binding (Molecular Function); Binding Proteins; Biological; Bordetella; Bordetella bronchiseptica; Bordetella pertussis; Bordetella pertussis Bacterium; Catecholamines; Cells; Chemotherapy-Hormones/Steroids; Complex; Cytoplasm; Defense Mechanisms; Effectiveness; Elements; Endocrine Gland Secretion; Enterobactin; Enterochelin; Environment; Epithelium, Respiratory; Excision; Exhibits; Extirpation; Family; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferredoxin-NADP Reductase; Ferredoxin[{..}]NADP+ oxidoreductase; Ferroprotoporphyrin; Gene Expression; Generalized Growth; Genes; Genetic; Granulocyte/Pollen-Binding Protein; Growth; Haemophilus pertussis; Heme; Heme b; Hormones; Host Factor; Host Factor Protein; Human; Human, General; In Vitro; Infection; Integration Host Factors; Investigation; Iron; Iron-Sulfur Protein Reductase; Knowledge; Lactoferrin; Lactotransferrin; Lead; Levarterenol; Levonorepinephrine; Life; Ligand Binding Protein; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Microbe; Molecular Interaction; NADPH-Ferredoxin Reductase; Nerve Transmitter Substances; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Neurotransmitters; Noradrenaline; Norepinephrine; Norepinephrine Receptors; Nutrient; Organism; Oxidases; Pathogenicity; Pattern; Pb element; Periplasmic Binding Proteins; Periplasmic Space; Pertussis; Proteins; Protoheme; Protoheme IX; Receptors, Norepinephrine; Removal; Research; Respiratory Infections; Respiratory Tract Infections; Retrieval; Role; Siderochromes; Siderophilin; Siderophores; Source; Staging; Starvation; Stress; Structure of respiratory epithelium; Surgical Removal; Sympathins; System; System, LOINC Axis 4; Therapeutic Hormone; Time; Tissue Growth; Transferrin; Virulence; Whooping Cough; Work; Yeasts; alcaligin; ferroheme; gene product; heavy metal Pb; heavy metal lead; improved; in vivo; interest; living system; member; mutant; novel; ontogeny; pathogen; pathogenic bacteria; periplasm; periplasmic; permease; prevent; preventing; psychological defense mechanism; public health relevance; resection; respiratory; response; social role; uptake",Iron Acquisition in Bordetella pertussis," PROJECT NARRATIVE Nearly all bacteria require iron for growth and pathogenic bacteria must be able to obtain this essential nutrient in the iron-limiting host environment. Bordetella pertussis is the causative agent of whooping cough, or pertussis, in humans and the related Bordetella bronchiseptica causes respiratory infections in a variety of nonhuman mammals. These bacteria use multiple mechanisms to obtain iron in the host and mutants defective in those mechanisms have dramatically reduced virulence. Information obtained in these studies will define the mechanisms of iron uptake and characterize host factors that influence the ability of these pathogens to obtain iron. This increased understanding may lead to improved strategies to prevent growth of these, and other respiratory pathogens, in humans.",31088,ZRG1,Special Emphasis Panel,A1,15,336798,
7781351,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI038382-17,,NIAID:405044;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"GALLOWAY, DENISE A.;",1867910;,2R01AI038382,05/15/1995,01/31/2015,"Active Follow-up; Address; Affinity; Amino Acids; Anogenital cancer; Anogenital venereal warts; Antibodies; Antibody Affinity; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Assay; Au element; B blood cells; B cell repertoire; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood; Blood Serum; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer of Cervix; Cancer of the Uterine Cervix; Capsid; Cervical; Cervical Cancer; Cervix Cancer; Chimera; Chimera organism; Collection; Complement; Complement Proteins; Computing Methodologies; Condyloma Accuminata; Condylomata Acuminata; Coupled; Coupling; DNA; Deoxyribonucleic Acid; Detection; Development; Diagnosis; Disease; Disorder; Dose; Douching, other than vaginal; Engineering; Engineerings; Epithelial Dysplasia; Epitopes; Exudate; Gamma Globulin, 7S; Gardasil; Genes, Ig; Genes, Immunoglobulin; Genetic Alteration; Genetic Change; Genetic defect; Genital; Genital Human Papilloma Virus Infection; Genital Human papillomavirus Infection; Genital system; Goals; Gold; HPV; HPV 16; HPV 31; HPV 6; HPV-16; HPV16; HPV31; HPV6; Human; Human Papillomavirus; Human papilloma virus 31; Human papilloma virus 6; Human papilloma virus infection; Human papilloma virus type 16; Human papilloma virus type 6; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus 31; Human papillomavirus 6; Human papillomavirus infection; Human papillomavirus type 16; Human papillomavirus type 6; Human papillomavirus, type 16; Human, General; Ig Somatic Hypermutation; IgG; Immune Globulins; Immune response; Immunoglobulin G; Immunoglobulin Genes; Immunoglobulin Somatic Hypermutation; Immunoglobulins; Immunoglobulins / Antibodies; Individual; Infection; Infectious Human Wart Virus; Intraepithelial Neoplasia; Intraepithelial Neoplasms; Investigators; Irrigation; Irrigation, other than vaginal; Knowledge; Lavage; Learning; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Neoplasm of the Cervix; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of cervix uteri; Man (Taxonomy); Man, Modern; Maps; Measures; Methods; Molecular Interaction; Mutation; Natural History; Nature; Nonvaginal irrigation; Nonvaginal lavage; Oligo; Oligonucleotides; Oral; Papilloma Virus, Human; Papillomavirus, Human; Point Mutation; Population; Position; Positioning Attribute; Prevalence; Process; Proteins; Public Health; Recombinants; Research Personnel; Research Specimen; Researchers; Reticuloendothelial System, Blood; Serologic; Serologic tests; Serological; Serological Tests; Serum; Sex Behavior; Sexual Activity; Sexual Behavior; Somatic Hypermutation, Immunoglobulin; Specificity; Specimen; Surface; Survey Instrument; Surveys; Tadpoles; Technology; Testing; Time; Vaccinated; Vaccination; Vaccines; Viral Diseases; Virion; Virus Diseases; Virus Particle; Warts, Genital; Warts, Venereal; Woman; aminoacid; antibody biosynthesis; antigen antibody affinity; antigen challenge; base; coat (nonenveloped virus); cohort; computational methodology; computational methods; computer methods; cross reactivity; disease/disorder; follow-up; gene product; genome mutation; host response; human papilloma virus 16; human papilloma virus type 31; human papillomavirus type 31; immunoglobulin biosynthesis; immunoresponse; improved; innovate; innovation; innovative; insight; interest; irrigation therapy; lavage therapy; men; men's; neutralizing antibody; neutralizing mAb; neutralizing monoclonal antibodies; new technology; optimism; postiive attitude; prevent; preventing; prophylactic; public health medicine (field); public health relevance; rapid method; rapid technique; response; serology; sex activity; somatic hypermutation; tool; uptake; urogenital system (genital part); viral infection; virus infection; wart virus",HPV Capsid Antibodies," Project Narrative ) Human papillomaviruses (HPVs) are the most common sexually transmitted viral infections, resulting in genital warts, intraepithelial neoplasia and anogenital cancers. Despite the optimism that has accompanied the introduction of prophylactic vaccines to prevent some HPV infections, the relatively modest uptake of the vaccine, especially in the developing world, and the very high fraction of men and women who are already infected, means that HPV-associated disease will remain a significant public health problem for decades. Thus, continuing to better understand the natural history of genital HPV infection and the basis for a protective immune response is an important goal.)",38382,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,17,405044,
7887121,R01,AI,2,,04/01/2010,03/31/2011,PA-07-070,2R01AI040101-15,,NIAID:453399;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"JOHNSON, JOHN ;",1891634;,2R01AI040101,07/01/1996,03/31/2015,"Address; Antiviral Therapy; Bacteriophages; Biological Models; Biology; Capsid; Capsid Proteins; Cells; Chemicals; Coat Proteins; Complex; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Esteroproteases; Event; Fluorescence; Goals; Grips; In Vitro; Investigation; Kinetic; Kinetics; Lead; Methods; Model System; Models, Biologic; Mole the mammal; Moles; Pb element; Peptidases; Peptide Hydrolases; Phages; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Resolution; Staging; Structure; System; System, LOINC Axis 4; Thermodynamic; Thermodynamics; Time; Viral Coat Proteins; Viral Gene Products; Viral Gene Proteins; Viral Outer Coat Protein; Viral Proteins; Virion; Virus; Virus Particle; Virus-like particle; Viruses, General; Work; bacterial virus; base; coat (nonenveloped virus); cross-link; crosslink; gene product; grasp; heavy metal Pb; heavy metal lead; in vivo; mutant; nano medicine; nanomedicine; novel; particle; programs; public health relevance; tomography; treatment of viral infectious disease; virus protein; viruslike particle",High Resolution Structural Studies dsDNA Bacteriophage," Project Narrative Virus maturation is virtually universal among complex viruses and is a worthy target for antiviral therapy. It is, however, very difficult to study because purified virions are fully mature. Grasping the details of the process requires accessible model systems where intermediates can be isolated and studied, as well as the transitions between them. HK97 is such a system and we are exploiting it to understand the structural, kinetic and thermodynamic parameters of particle maturation.",40101,ZRG1,Special Emphasis Panel,,15,453399,
7770378,R01,AI,2,,01/15/2010,12/31/2011,PA-07-070,2R01AI041440-11A2,,NIAID:413750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"FIKRIG, EROL ;",1870639;,2R01AI041440,06/01/1998,12/31/2015,"Alpha-Fucosyltransferases; Anaplasma; Anaplasma phagocytophila; Anaplasma phagocytophilum; Anaplasmosis; Area; Arthropod Vectors; Arthropoda; Arthropods; Biological; Black-legged Tick; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bovine Anaplasmosis; Cells; Cytoecetes phagocytophila; Data; Deoxygalactose; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Ehrlichia equi; Ehrlichia phagocytophila; Fucose; Fucosyltransferase; GFP; Gene Expression; Genes; Genome; Goals; Green Fluorescent Proteins; HGE Agent; Head and Neck, Salivary Glands; Heterophil Granulocyte; Human; Human, General; I. scapularis; Infection; Infection prevention; Investigation; Ixodes scapularis; Ixodid ticks; Ixodida; Knock-in; Knock-in Mouse; Knowledge; Lead; Lentiviral Vector; Lentivirus Vector; Life Cycle; Life Cycle Stages; Location; Mammalia; Mammalian Cell; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mediating; Medical; Modeling; Modification; Neutrophilic Granulocyte; Neutrophilic Leukocyte; North America; Oxidative Burst; Pathogenesis; Pb element; Phase; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevent infection; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Refractory; Respiratory Burst; Role; Salivary Gland Proteins; Salivary Glands; Salivary Proteins; Sequence-Specific Posttranscriptional Gene Silencing; System; System, LOINC Axis 4; Technology; Tick-Borne Diseases; Ticks; United States; Work; Zoonoses; alpha-Fucose; base; combat; disease/disorder; gene product; heavy metal Pb; heavy metal lead; human granulocytic ehrlichiosis; leukocyte oxidative burst; life course; neutrophil; pathogen; prevent; preventing; public health relevance; respiratory burst (leukocyte); social role; vector",Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis," Project Narrative  Human granulocytic anaplasmosis (HGA), previously known as human granulocytic ehrlichiosis, is the second most common tick-borne illness in North America. The causative agent is Anaplasma phagocytophilum, an obligate intracellular pathogen that persists within neutrophils in the mammalian host, and also in cells within Ixodes scapularis ticks. The goal of this proposal is to develop a better understanding of the relationship between A. phagocytophilum and its tick vector, I. scapularis. A. phagocytophilum alters the expression of several mammalian genes during infection of neutrophils, and this pathogen also influences the expression of specific I. scapularis genes. By understanding these A. phagocytophilum-tick interactions in greater detail, we will develop new ways to interfere with the A. phagocytophilum life cycle. These studies should lead to a greater understanding of A. phagocytophilum pathogenesis and may suggest new ways to prevent infection. It is also hopeful that these paradigms would also be applicable to other vector-borne pathogens of medical importance.",41440,VB,Vector Biology Study Section,A2,11,413750,
7888660,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI044076-11A1,,NIAID:354226;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ANN ARBOR,UNITED STATES,SURGERY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"TEITELBAUM, DANIEL H;",1889421;,2R01AI044076,07/01/1999,01/31/2015,"21+ years old; Abscission; Address; Adult; Affect; Anthelone U; Applications Grants; Architecture; Atrophic; Atrophy; Automobile Driving; Bacterial Translocation; Binding; Binding (Molecular Function); Blood Poisoning; CSIF; CSIF-10; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell-to-Cell Interaction; Cellular Function; Cellular Physiology; Cellular Process; Childhood; Clinical; Communicable Diseases; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytoplasmic Membrane; Data; Disintegrins; Drivings, Automobile; Dysfunction; EGF; EGFR; ERBB Protein; ERBB1; Engineering / Architecture; Enteral Feeding; Enteral Nutrition; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor-Urogastrone; Epithelial; Epithelial Cell Proliferation; Epithelial Cells; Excision; Extirpation; Functional disorder; GFAC; Gamma interferon; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gln; Glutamine; Goals; Grant; Grant Proposals; Grants, Applications; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HER1; Human; Human Urinary Gastric Inhibitor; Human, Adult; Human, General; IFN-Gamma; IFN-g; IFNG; IL-10; IL10; IL10A; Immune; Immune system; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 10 Precursor; Interleukin-10; Intestinal; Intestines; Intracellular Communication and Signaling; Intravenous; L-Glutamine; Laboratories; Lead; Ligands; Lymphocyte; Lymphocytic; Lymphoid; Lymphoid Cell; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediation; Medical; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Mice, Transgenic; Modeling; Molecular Interaction; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Negotiating; Negotiation; Nutrition; Nutritional Science; Operation; Operative Procedures; Operative Surgical Procedures; PI3CG; PI3KGamma; PI3k; PIK3; PIK3CG; PIK3CG gene; Parenteral Hyperalimentation; Parenteral Nutrition, Total; Pathway interactions; Patients; Pb element; Phenotype; Phosphorylation; Physiologic; Physiological; Physiopathology; Plasma Membrane; Population; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Q. Levoglutamide; Receptor Protein; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Removal; Rodent Model; Science of nutrition; Septicemia; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Total Parenteral Nutrition; Toxin; Transforming Growth Factor alpha Receptor; Transgenic Mice; Ubiquitilation; Ubiquitination; Ubiquitinoylation; United States; Urogastrone; Villus; Work; adult human (21+); beta-Urogastrone; biological signal transduction; body system, allergic/immunologic; bowel; c-erbB-1; c-erbB-1 Protein; cost; cytokine; driving; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gastrointestinal disorder; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; insight; intraepithelial; lFN-Gamma; lymph cell; lymphocyte proliferation; metalloproteinase (general); mouse model; novel; nutrition; organ system, allergic/immunologic; pathogen; pathophysiology; pathway; pediatric; plasmalemma; prevent; preventing; proto-oncogene protein c-erbB-1; public health relevance; receptor; receptor expression; research study; resection; septicaemia; surgery; ubiquination; ubiquitin conjugation",TPN Induced Changes in Intraepithelial Lymphocytes," Project Narrative: Surgical patients who cannot tolerate enteral feedings are critically dependent on total parenteral nutrition (TPN), or intravenous nutrition. However, TPN is associated with a loss of epithelial barrier function (EBF), which can lead to the transit of luminal pathogens and toxins into the host. Using a mouse model of TPN and novel transgenic mice and promoters and inhibitors of intracellular signaling this proposal will examine the mechanisms which lead to this loss of EBF. Beyond this goal, the information derived from this proposal will augment our basic understanding of a number of other gastrointestinal disease processes where barrier function is lost, including inflammatory bowel disease and infectious disorders of the intestine.",44076,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1,11,354226,
7908167,R01,AI,2,,03/01/2010,02/28/2011,PA-07-070,2R01AI047891-12,,NIAID:420000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MEMPHIS,UNITED STATES,,09,067717892,US,TN,38105,ST. JUDE CHILDREN'S RESEARCH HOSPITAL,"GREEN, DOUGLAS R;",1861713;,2R01AI047891,07/01/2000,02/28/2015,"Address; Affect; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Biochemistry; CAP4 protease; CASP8 Protein; Caspase-8/Flice; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell-Death Protease; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemistry, Biological; Cleaved cell; DNA Damage; DNA Injury; Enzymes; Esteroproteases; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Genome Instability; Genomic Instability; Golgi; Golgi Apparatus; Golgi Complex; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; ICE-like protease; Ich-1 protein; Image; Imaging Procedures; Imaging Techniques; Life; Location; Lymphomagenesis; MACH protein; Mammals, Mice; Mch5 protease; Metabolic; Mice; Mitochondria; Modeling; Molecular; Murine; Mus; Nedd-2 protein; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Oncogenesis; Orphan; Peptidases; Peptide Hydrolases; Process; Proteases; Proteinases; Proteolytic Enzymes; Research; Risk; Role; Stress; Subcellular Process; Technics, Imaging; Testing; Time; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; adapter protein; base; biological adaptation to stress; caspase; caspase-2; caspase-8; cell imaging; cellular imaging; cleaved; cystein protease; cystein proteinase; cysteine endopeptidase; d-Numb; dimer; enzyme activity; imaging; insight; mitochondrial; monomer; necrocytosis; neuronal; new approaches; novel; novel approaches; novel strategies; novel strategy; numb protein; public health relevance; reaction; crisis; response; social role; stress response; stress; reaction; tumor growth; tumor suppressor; tumorigenesis",Activation and Function of Caspase-2," Relevance Statement Our finding that caspase-2 is activated by heat shock, combined with the recent finding that caspase-2 functions as a tumor suppressor in a murine model of lymphomagenesis, raise fundamental questions about how this caspase functions in cellular physiology. The studies proposed herein will provide mechanistic insights into these functions.",47891,CAMP,Cancer Molecular Pathobiology Study Section,,12,420000,
7888926,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI049660-06A1,,NIAID:383541;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCHESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"SANZ, IGNACIO E.;",6081933;,2R01AI049660,04/01/2001,01/31/2015,"ATGN; Antibodies; Antigens; Apoptotic; Atrophic Arthritis; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; Binding; Binding (Molecular Function); Biological Models; Blood Plasma Cell; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C2B8 Monoclonal Antibody; Cells; Clinical; Cytofluorometry, Flow; DNA Recombination; DNA recombination (naturally occurring); Defect; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; Disorder; Effector Cell; Elements; Ensure; Event; Exclusion; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Funding; Genetic Recombination; Germinal Center; Goals; Heterogeneity; Human; Human, General; Ig Somatic Hypermutation; Immunoglobulin Somatic Hypermutation; Inflammatory Arthritis; Kidney; Light; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lupus Glomerulonephritis; Lupus Nephritis; Man (Taxonomy); Man, Modern; Measurement; Measures; Memory; Mice, Transgenic; Microfluorometry, Flow; Moab, Clinical Treatment; Model System; Models, Biologic; Molecular; Molecular Interaction; Monoclonal Antibodies; Patients; Photoradiation; Plasma Cells; Plasmacytes; Population; Reagent; Receptor Protein; Recombinants; Recombination; Recombination, Genetic; Regulation; Rest; Rheumatoid Arthritis; Rituximab (C2B8 Antibody); Role; SLE; SLE - Lupus Erythematosus, Systemic; Somatic Hypermutation, Immunoglobulin; Specificity; Structure of germinal center of lymph node; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Technology; Testing; Transgenic Mice; Urinary System, Kidney; anergy; autoimmune disorder; autoreactive B cell; autoreactivity; base; biomarker; diabetes; disease/disorder; disseminated lupus erythematosus; flow cytophotometry; immunogen; improved; mouse model; plasmocyte; prevent; preventing; public health relevance; receptor; renal; response; rituximab; self recognition (immune); single cell analysis; social role; somatic hypermutation; systemic lupus erythematosis; therapeutic target",A Model System for the Study of Human B-cell Tolerance," Autoimmune diseases like SLE are triggered by lack of regulation of cells that recognize our own antigens. Understanding the regulation of these cells (called autoreactive B cells) will be of great importance for the diagnosis of treatment of multiple autoimmune diseases also including Rheumatoid Arthritis and Diabetes. We will use a well-recognized subset of human autoreactive B cells (termed 9G4) that are specifically defective in patients with SLE. Using molecular and cellular approaches, we will elucidate the mechanisms, antigens and precise points of deregulation of these cells.",49660,TTT,"Transplantation, Tolerance, and Tumor Immunology",A1,6,383541,
7899711,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI052352-06A2,,NIAID:351000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"ALEGRE, MARIA-LUISA ;",6415467;,2R01AI052352,07/01/2002,01/31/2015,"Acute; Adverse effects; Allogenic; Allografting; Antirejection Therapy; Apoptosis; Apoptosis Pathway; Autoimmune; Autoimmune Process; C 3-5 Converting Enzyme; C3 Proactivator; C3PA; CVFBb; Cachectin Receptors; Cell Death, Programmed; Cells; Clinic; Clinical; Clinical, Transplantation, Organ; Cohort Effect; Complement 3 Proactivator; Complement Factor B; Complement Factor B, Alternative Pathway; Complement Protein B; Complement Protein Factor B; Dendritic Cells; Development; Disease; Disorder; Drugs; Factor B; Family member; Funding; Generation Effect; Generations; Goals; Graft Rejection; Grafting Procedure; Immune response; Immunoglobulin Enhancer-Binding Protein; Immunosuppressants; Immunosuppressive Agents; Immunosuppressive Therapy; In Vitro; Link; Lymph node proper; Mammals, Mice; Medication; Mice; Mice, Transgenic; Modeling; Molecular; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Organ System; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Pathogenesis; Pathway interactions; Peyer's Patches; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Population; Position; Positioning Attribute; Properdin Factor B; Receptor Protein; Regulatory T-Lymphocyte; Reticuloendothelial System, Lymph Node; Role; Solid; Structure of aggregated lymphoid follicle of small intestine; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; TLR protein; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; Testing; Therapeutic immunosuppression; Therapy, Anti-Rejection; Thymus-Dependent Lymphocytes; Toll-like receptors; Transcription Factor NF-kB; Transgenic Mice; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation Surgery; Transplantation Tolerance; Treatment Side Effects; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Veiled Cells; allograft rejection; artificial immunosuppression; body system; cardiac allograft; cell type; disease/disorder; drug development; drug/agent; experiment; experimental research; experimental study; heart allograft; host response; immunoresponse; immunosuppression; immunosuppressive; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; kappa B Enhancer Binding Protein; lymph gland; lymph nodes; novel; nuclear factor kappa beta; organ allograft; organ graft; organ xenograft; pathway; prevent; preventing; public health relevance; receptor; research study; side effect; social role; therapeutic target; therapy adverse effect; thymocyte; thymus derived lymphocyte; tool; transcription factor; transplant; treatment adverse effect",Role of NF-kB Activation in Acute Allograft Rejection," Project Narrative We have recently shown that mice lacking CARMA1, an adaptor linking TCR to NF-kB, accept cardiac allografts long-term, suggesting that therapeutic targeting of this pathway may be sufficient for the induction of transplantation tolerance. Preliminary experiments reveal that the CARMA1 deficiency results in inhibition of Th17 and nTreg differentiation whereas it facilitates the generation of iTregs, positioning this molecule as having opposite effects for generation of nTregs versus iTregs. In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-kB regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate.",52352,TTT,"Transplantation, Tolerance, and Tumor Immunology",A2,6,351000,
7783304,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI054544-07A2,,NIAID:369656;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"RAM, SANJAY ;",6912495;,2R01AI054544,04/01/2003,01/31/2015,"0-11 years old; ATGN; Address; Affect; Animal Model; Animal Models and Related Studies; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Antigens; Arm; Au element; Bacteria; Binding; Binding (Molecular Function); Binding Proteins; Blood; Blood Circulation; Blood Serum; Bloodstream; C 3-5 Converting Enzyme; C 5b-9; C3 Proactivator; C3PA; C4 b; C4b; C5b-9; CAPS; CVFBb; Capsules; Cerebrospinal Fluid; Child; Child Youth; Children (0-21); Circulation; Classical Complement Pathway; Clinical; Complement; Complement 3 Proactivator; Complement 4b; Complement Activation; Complement C4b; Complement Complex C5b-9; Complement Factor B; Complement Factor B, Alternative Pathway; Complement Factor H; Complement Factor P; Complement Membrane Attack Complex; Complement Pathway, Classical; Complement Protein B; Complement Protein Factor B; Complement Proteins; Complex; Cytolytic Terminal Complement Complex; Defense Mechanisms; Deposit; Deposition; Development; Disease; Disorder; Encapsulated; Epidemiology; Equilibrium; Factor B; Factor H; Fc domain; Feedback; Funding; Gamma Globulin, 19S; Gamma Globulin, 7S; Genome; Glycans; Goals; Gold; Grant; Health; Host Defense; Human; Human, Child; Human, General; Hybrids; IgG; IgG1; IgM; Immune; Immunization; Immunoglobulin G; Immunoglobulin M; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inactivated Vaccines; Inactivated Virus Vaccine; Infection; Invaded; Killings; Knowledge; Lead; Life; Ligand Binding Protein; Ligands; Lipoproteins; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Attack Complex; Membrane Proteins; Membrane-Associated Proteins; Meningitis, Meningococcic; Meningococcal Infections; Meningococcal meningitis; Meningococcus; Microbe; Miscellaneous Antibiotic; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucosa; Mucosal Tissue; Mucous Membrane; Nasopharynx; Neisseria; Neisseria meningitidis; Organism; Oryctolagus cuniculus; Outcome; Pathogenesis; Pathway interactions; Pb element; Persons; Polysaccharides; Properdin; Properdin Factor B; Protein Binding; Proteins; R Factors; R Plasmids; Rabbit, Domestic; Rabbits; Recurrence; Recurrent; Regulation; Resistance; Resistance Factors; Reticuloendothelial System, Blood; Rhinopharynx; Role; Sensitization, Immunologic; Sensitization, Immunological; Sepsis; Serum; Site; Specificity; Surface; Surface Proteins; System; System, LOINC Axis 4; Terminal Complement Complex; Upper arm; Vaccination; Vaccines; Vaccines, Inactivated; Vaccines, Killed; Virulence; adult youth; bactericidal; bactericide; balance; balance function; base; blocking factor; bloodstream infection; capsule (pharmacologic); children; complement deficiency; complement pathway; complement pathway regulation; design; designing; disease prevention; disease/disorder; disorder prevention; ethanolamine phosphate; factor P; gene product; heavy metal Pb; heavy metal lead; immunogen; improved; inhibitor; inhibitor/antagonist; insight; lipid-linked oligosaccharides; lipooligosaccharide; living system; membrane structure; model organism; nasopharnygeal; novel; pathogen; pathway; phosphoethanolamine; phosphorylethanolamine; polyanion; psychological defense mechanism; public health relevance; resistant; social role; spinal fluid; vaccine candidate; vaccine development; vaccine efficacy; vaccine evaluation; vaccine screening; vaccine testing; young adult; youngster",Complement Activation on Neisseria meningitidis," Meningococcal meningitis and sepsis is a major health problem worldwide. It mainly affects children and young adults and is a significant cause of morbidity and mortality. Although a good vaccine exists against several meningococcal serogroups, there is no effective vaccine against serogroup B disease. The emergence of disease caused by strains that lack a capsule following vaccination campaigns using capsular polysaccharide-based vaccines is of concern. Complement forms an important arm of host defenses against the meningococcus. The studies proposed in this grant will help us better understand how this pathogen escapes killing by complement and will ultimately aid in the development of better vaccines against meningococcal meningitis.",54544,HIBP,Host Interactions with Bacterial Pathogens Study Section,A2,7,369656,
7779900,R01,AI,2,,01/15/2010,12/31/2010,PA-07-070,2R01AI055037-06A1,,NIAID:395398;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"DUSTIN, MICHAEL L;",2418028;,2R01AI055037,08/01/2003,12/31/2014,"(2,6)-sialyl T antigen; APC; ATGN; Antigen Receptors; Antigen-Presenting Cells; Antigens; Antigens, LD; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; Body Tissues; Bypass; CCL19; CCL19 gene; CCL21; CCL21 gene; CKb11; CKb9; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell surface; Cell-to-Cell Interaction; Cells; Closure by Ligation; Complex; Cytokines, Chemotactic; Data; Dendritic Cells; EC 2.7; Electron Microscopy; Environment; Eragrostis; Event; FLR; Failure (biologic function); Frequencies (time pattern); Frequency; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Generations; Homologous Chemotactic Cytokines; Hour; Immunologic Accessory Cells; In Vitro; Inflammatory; Injury; Intercrines; Intestinal; Intestines; Intracellular Communication and Signaling; Kinases; Lead; Ligands; Ligation; Light; Location; Lymph node proper; Lymphatic Tissue; Lymphocyte; Lymphocyte antigen; Lymphocytic; Lymphoid Tissue; MGC34433; MGC34555; MHC Receptor; MIP-3b; MIP3B; Major Histocompatibility Complex Receptor; Mediating; Monocytes / Macrophages / APC; Movement; PKC; Pathway interactions; Pb element; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Peripheral; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphotransferases; Photoradiation; Protein Kinase C; Receptor Protein; Receptors, Antigen; Receptors, Antigen, T-Cell; Regulation; Regulatory T-Lymphocyte; Reticuloendothelial System, Lymph Node; Role; SCYA19; SCYA21; SIS cytokines; SLC; ST antigen; Self-Antigens; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Synapses; Synaptic; System; System, LOINC Axis 4; T Antigens; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; TCA4; Teff; Testing; Thymus-Dependent Lymphocytes; Time; Tissues; Transphosphorylases; Veiled Cells; Viral T Antigens; Viral Tumor Antigens; Virus Transforming Antigens; accessory cell; anergy; base; biological signal transduction; body movement; bowel; chemoattractant cytokine; chemokine; chemokine receptor; dosage; experiment; experimental research; experimental study; failure; heavy metal Pb; heavy metal lead; immunogen; immunological synapse; in vivo; lymph cell; lymph gland; lymph nodes; lymphocyte differentiation antigen; member; migration; pMHC; pathway; prevent; preventing; public health relevance; receptor; research study; response; s-T antigen; self recognition (immune); sialosyl-T antigen; social role; synapse formation; synapse inhibition; synaptic inhibition; synaptogenesis; thymus derived lymphocyte; vaccination strategy",Environmental control of the immunological synapse," Project Narrative: Vaccination strategies depend upon a physical embrace between antigen specific T lymphocytes and antigen presenting dendritic cells. We hypothesize that the stability of this embrace will depend upon the quality of antigen that defines a stop signal for the migrating T cell, signals in the environment that provide a competing go signal to the lymphocyte and polarity networks controlled by kinases. We propose experiments to determine the roles of chemokines, dendritic cell frequency and regulatory T cell protein kinase C-¨ in tolerance induction.",55037,ZRG1,Special Emphasis Panel,A1,6,395398,
7886430,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI055849-06A1,,NIAID:158334;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,PATHOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"HANSEN, TED HOWARD;",1868191;,2R01AI055849,03/01/2004,01/31/2015,"APC; ATGN; Affinity; Antigen Presentation; Antigen-Presenting Cells; Antigens; Arthropoda; Arthropods; Bacteria; Binding; Binding (Molecular Function); CD8; CD81; CD81 gene; CD8B; CD8B1; CD8B1 gene; Cell surface; Cells; Class I Antigens; Class I Major Histocompatibility Antigens; Complex; Complex Class 1; Cross Presentation; DNA; DNA Vaccines; Deoxyribonucleic Acid; Disease; Disorder; Disulfides; Engineering; Engineerings; Grant; Histocompatibility Antigens Class I; Immune system; Immunity; Immunologic Accessory Cells; Infection; LYT3; Lymph node proper; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; Major Histocompatibility Complex Class 1; Mammals, Mice; Membrane; Mice; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Murine; Mus; Naked DNA Vaccines; Pathway interactions; Peptides; Reticuloendothelial System, Lymph Node; Role; Secure; Skin; T-Cells; T-Lymphocyte; TAPA-1; TAPA1; TSPAN28; Testing; Thymotaxin; Thymus-Dependent Lymphocytes; Vaccination; Vaccines; Vaccines, DNA; Vaccines, Recombinant DNA; Virus; Viruses, General; accessory cell; base; beta-2 Microglobulin; body system, allergic/immunologic; design; designing; disease/disorder; efficacy testing; immunogen; in vivo; lymph gland; lymph nodes; membrane structure; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathogen; pathway; public health relevance; response; social role; thymus derived lymphocyte; tumor; vaccine efficacy",SCT PROBES FOR PATHOGEN IMMUNITY," PROJECT NARRATIVE Protective immunity to several pathogens requires that MHCI molecules bind antigenic peptides for presentation to CD8 T cells. However, to bind MHCI molecules, pathogen-derived peptides must compete with an extensive pool of endogenous peptides of the host. We have engineered MHCI molecules so that they can be pre-loaded with pathogen-derived peptides. In this grant, we will test the efficacy and mechanism of using these pre-loaded MHCI as vaccines.  ",55849,IHD,Immunity and Host Defense Study Section,A1,6,158334,
7890297,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI056222-06A1,,NIAID:389151;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"FARRAR, JOHN DAVID;",1893928;,2R01AI056222,07/01/2003,01/31/2015,"Address; Affect; Allergic; Allergy; Asthma; B Cell Differentiation Factor I; B cell activating factor; B cell growth factor; B cell growth factor 2; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Growth Factor-II; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Bronchial Asthma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cells, CD4; Cellular Immunity; Chronic; Data; Dendritic Cells; Development; Disease; Disorder; EDF; Edodekin Alfa; Environment; Eo-CSF; Eosinophil Differentiation Factor; GATA-3 factors; GATA-3 protein; GATA3 protein; GATA3 transcription factor; Grant; HCV infection; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Human; Human Development; Human, General; Hypersensitivity; IFN; IL-12; IL-13; IL-4; IL-5; IL12; IL13; IL4; IL4 Protein; IL5; INFLM; IgA enhancing factor; Immune; Immunity, Cellular; Individual; Inducer Cells; Infection; Inflammation; Inflammatory; Inhalators; Inhaler; Interferon Type I; Interferons; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin-12; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Interleukin-5; Intervention; Intervention Strategies; Life; Lung; Lung diseases; Lymphocyte Stimulatory Factor 1; MCGF-2; MS (Multiple Sclerosis); Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Mediating; Molecular; Multiple Sclerosis; NANBH; NKSF; Natural Killer Cell Stimulatory Factor; Organism; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Pathology; Pathway interactions; Patients; Phenotype; Process; Production; Pulmonary Diseases; Pulmonary Disorder; Regulation; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Sclerosis, Disseminated; Shapes; T cell replacing factor; T-Cell Growth Factor 2; T-Cell Replacing Factor; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Th-2 Cell; Th2 Cells; Thymus-Dependent Lymphocytes; Type 2 Helper Cell; Veiled Cells; Viral Diseases; Virus Diseases; asthmatic patient; base; cytokine; disease/disorder; efficacy testing; helper T cell; hepatitis non A non B; hepatitis nonA nonB; in vivo; insular sclerosis; interventional strategy; living system; lung disorder; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; novel therapeutic intervention; pathway; public health relevance; pulmonary; response; social role; thymus derived lymphocyte; viral infection; virus infection",Type I Interferon-Regulated T Helper Development," Project Narrative Asthma is a debilitating inflammatory disease of the lungs that affects millions of people worldwide. While various therapies are in place to provide temporary relief, and in some cases immediate life- saving intervention with inhalers, no treatment has been developed that blocks the chronic progression and maintenance of the disease. Asthma is an immune-mediated disorder caused by the inappropriate activation of CD4+ T cells to normally innocuous molecules in the environment. These activated T cells secrete soluble cytokines, such as interleukin-4, that activate a cascade of inflammatory processes in the lung. Thus, CD4+ T cells represent the primary target for reversing the pathogenesis of asthma. In our studies, we have found that a unique cytokine, type I interferon (IFN- a/b), potently blocks the development of these inflammatory T cells and inhibits their ability to secrete cytokines. Based on this observation, this proposal seeks to understand the mechanism by which IFN-a/b reverses these pathogenic T cells and will determine whether IFN-a/b can block cytokine secretion from these inflammatory T cells isolated from asthma sufferers. These studies will lay the groundwork for more effective and long-lasting treatment for allergy and asthma.",56222,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",A1,6,389151,
7885195,R01,AI,2,,01/15/2010,12/31/2010,PA-07-070,2R01AI057472-06A1,,NIAID:422500;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"FISCHETTI, VINCENT A.;",1884587;,2R01AI057472,01/15/2010,12/31/2014,"Affect; Animals; Anthrax; Anthrax disease; B. anthracis; Bacillus anthracis; Bacteriophages; Belief; Biologic Products; Biological Agent; Biological Products; Categories; Collection; Disease Outbreaks; Ecology; Environment; Environmental Science; Enzymes; Exposure to; F. tularensis; Francisella tularensis; Functional Metagenomics; Gene Transcription; Genetic; Genetic Techniques; Genetic Transcription; Grant; Human; Human, General; Infection; Infection prevention; Killings; Libraries; Life; Life Style; Lifestyle; Lysogeny; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Metagenomics; Methods; Microbial Biofilms; Nature; Outbreaks; Pasteurella pestis; Pasteurella tularensis; Phages; Phase; Phenotype; Pheretima sieboldi; Plague; Plasmids; Prevent infection; Process; Prophage Integration; Prophages; Publications; RNA Expression; Regulon; Reproduction spores; Scientific Publication; Series; Sigma Element; Sigma Factor; Sigma Initiation Factor; Sigma Subunit; Soil; Spores; System; System, LOINC Axis 4; Technics, Genetic; Thinking; Thinking, function; Time; Transcription; Transcription, Genetic; Tularemia; Virulence; Virus; Viruses, General; Work; Y. pestis; Y.pestis; Yersinia pestis; Yersinia pestis disease; anthracis; bacterial virus; biofilm; biopharmaceutical; biotherapeutic agent; design; designing; earthworm; innovate; innovation; innovative; mutant; novel; pathogen; pathogenic bacteria; public health relevance",Isolation of new phage enzymes to kill B. anthracis," Project Narrative: We have discovered for the first time that the anthrax agent Bacillus anthracis can survive outside the infected host in long-lived, non-spore forms and in novel niches as a result of being infected by environmental bacteriophages. This new information will now enable us to examine similar occurrences in other Category A biological agents with extended soil phases, like Yersinia pestis (the plague agent) and Francisella tularensis (the tularemia agent). This latest information changes our thinking about the versatility of these pathogens, allowing us to devise innovative strategies to control them both in the environment and during infection.",57472,BACP,Bacterial Pathogenesis Study Section,A1,6,422500,
7887578,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI060921-06A1,,NIAID:398959;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"FREEDMAN, BRUCE D;",1899588;,2R01AI060921,06/01/2004,01/31/2015,"ATP[{..}]protein-tyrosine O-phosphotransferase; Adaptor Protein; Adaptor Signaling Protein; Antibodies; Antigen Receptors; Autoimmune; Autoimmune Process; B blood cells; B-Cells; B-Lymphocytes; BLNK; BLNK gene; BLNK-s; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Ca++ element; Calcium; Calcium Ion Signaling; Calcium Signaling; Cations; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cellular Matrix; Clinic; Coagulation Factor IV; Coupling; Cytoplasm; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Data; Development; Disease; Disorder; Distal; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endoplasmic Reticulum; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Ergastoplasm; Factor IV; GOK Gene; Generations; HEK3; IP3R; IP3R1; ITPR1; ITPR1 gene; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immune response; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunologic Diseases; Immunological Deficiency Syndromes; Immunological Diseases; Inflammatory; Insp3r1; Intracellular Communication and Signaling; Intracellular Second Messengers; Kinases; L-Tyrosine; Link; Lipase; Ly57; Lymphocyte; Lymphocyte Function; Lymphocytic; Mediating; Membrane; Microinjections; Molecular; Molecular Interaction; PTK; Pathway interactions; Phosphorylation; Phosphotransferases; Plasma Membrane; Play; Point Mutation; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Receptor Protein; Receptors, Antigen; Regulation; Role; SLP-65; SLP65; STIM1; STIM1 gene; Second Messenger Systems; Second Messengers; Signal Transduction; Signal Transduction Systems; Signaling; Stromal Interaction Molecule 1 Gene; Structure; Suggestion; T-Cell Activation; TRP3 channel; TRP3 protein; TRPC3 channel; TRPC3 ion channel; TRPC3 protein; TYR; Testing; Transphosphorylases; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triolean Hydrolase; Tyrosine; Tyrosine Kinase; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; base; biological signal transduction; disease/disorder; gene product; host response; hydroxyaryl protein kinase; hypoimmunity; immune deficiency disorder; immunodeficiency; immunoresponse; inhibitor; inhibitor/antagonist; insight; intracellular skeleton; lymph cell; membrane structure; novel; para-Tyrosine; pathway; plasmalemma; public health relevance; receptor; second messenger; sensor; social role; tributyrase; tyrosyl protein kinase",Novel Mechanisms of Calcium Signaling in B lymphocytes, Narrative: Calcium is a multifunctional second messenger that regulates nearly every aspect of lymphocyte differentiation and function and thereby the immune response. The primary objective of these studies is to understand novel mechanisms by which calcium entry into lymphocytes is regulated. Results from these studies will identify targets and strategies both positive and negative manipulation of the immune response to ameliorate immunodeficiency diseases and/or to suppress development of autoimmune and inflammatory disease.,60921,CMIB,Cellular and Molecular Immunology - B Study Section,A1,6,398959,
7887058,R01,AI,2,,04/01/2010,03/31/2011,PA-07-070,2R01AI061576-06A1,,NIAID:410000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"DIMOPOULOS, GEORGE DIMOPOULOS;",7743219;,2R01AI061576,07/01/2004,03/31/2015,"Address; Anopheles; Anopheles Genus; Applied Genetics; Assay; Bacteria; Bioassay; Biologic Assays; Biological Assay; Blood; Body Tissues; Computer Systems Development; Culicidae; DISSEC; Development; Development, Computer Systems; Disease; Disorder; Dissection; Exposure to; Genes; Genetic; Goals; Human; Human, General; Immune; Immune response; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; Infection; Insecta; Insects; Invertebrates, Insects; Killings; Life Cycle; Life Cycle Stages; Link; Malaria; Man (Taxonomy); Man, Modern; Mediating; Microbe; Molecular; Mosquito Control; Mosquitoes; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Nature; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nuclear Translocation; Paludism; Parasites; Pathway interactions; Phenotype; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Refractory; Regulation; Research; Research Proposals; Resistance; Resistance development; Resistant development; Reticuloendothelial System, Blood; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Staging; Study models; System; System, LOINC Axis 4; Systems Development; Time; Tissues; Transcription Factor NF-kB; Transgenes; Transgenic Organisms; Virus; Viruses, General; body system, allergic/immunologic; combinatorial; cost; developing resistance; disease/disorder; fight against; fitness; functional genomics; fungus; host response; immunoresponse; interest; kappa B Enhancer Binding Protein; life course; microbial; nuclear factor kappa beta; organ system, allergic/immunologic; pathogen; pathway; public health relevance; resistant; response; tool; trait; transcription factor; transgenic",Dissection of Anopheles Responses to Plasmodium Infected Blood, NARRATIVE    The Anopheles mosquito uses its innate immune system to fight against a broad spectrum  of microbial pathogens including the Plasmodium parasite. We have shown that the IMD  immune signaling pathway is a major player in anti-Plasmodium defense. This research  proposal aims at the molecular dissection of IMD pathway mediated Plasmodium  resistance in A. gambiae. ,61576,VB,Vector Biology Study Section,A1,6,410000,
7942682,R01,AI,2,,03/01/2010,02/28/2011,PA-07-070,2R01AI062427-06,,NIAID:422792;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,GENETICS,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"BERMAN, JUDITH G.;",1902385;,2R01AI062427,06/01/2005,02/28/2015,"1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Allelic Loss; Aneuploid; Aneuploidy; Antifungal Agents; Antifungal Drug; Antifungal Drug Resistance; Antifungal Drug Resistant; Antifungal Therapy; Antifungal resistant; Arm; Azole resistance; Azole resistant; Azoles; C. albicans; C.albicans; CNP; Candida; Candida albicans; Candidate Disease Gene; Candidate Gene; Candidiasis; Candidosis; Cause of Death; Cells; Chromosome 5; Chromosomes; Chromosomes, Human, Pair 5; Clinical; Companions; Complication; Copy Number Polymorphism; DNA Recombination; DNA recombination (naturally occurring); Data; Drug Resistance, Fungal; Drug usage; Drugs; Esophageal; Event; Evolution; Fluconazole; Frequencies (time pattern); Frequency; Funding; Fungal Drug Resistance; Fungicides, Therapeutic; Fungus Diseases; Fungus drug resistant; Gene Copy Number; Gene Dosage; Genes; Genetic; Genetic Recombination; Genome; Genomics; Goals; HIV; HTLV-III; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Individual; Infection; Isochromosomes; LAV-HTLV-III; Left; Length of Life; Letters; Longevity; Loss of Heterozygosity; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Manuscripts; Medication; Molecular; Monilia; Moniliasis; Mycoses; Opportunistic Infections; Oropharyngeal; Oropharyngeal Candidiasis; Oropharynx; Oropharynxs; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prevalence; Process; Recombination; Recombination, Genetic; Resistance; Role; Stress; Survey Instrument; Surveys; TXT; Testing; Tetraploidy; Text; Upper arm; Virus-HIV; Work; alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; anti-fungal; anti-fungal drug resistance; anti-fungal drug resistant; anti-fungal resistance; anti-fungal resistant; antifungal resistance; antifungals; assault; biological adaptation to stress; chromosome loss; coping; copy number variation; diflucan; drug use; drug/agent; echinocandin resistance; echinocandin resistant; fungal infection; fungus; fungus drug resistance; fungus infection; immunosuppressed patient; life span; lifespan; novel therapeutic intervention; oral pharyngeal; oropharyngeal thrush; pathogen; pathway; prophylactic; public health relevance; reaction; crisis; resistance to anti-fungal; resistance to antifungal; resistance to azole; resistant; resistant strain; resistant to anti-fungal; resistant to antifungal; resistant to azole; response; social role; stress response; stress; reaction; tool; treatment of fungal infectious disease",Genome Integrity in Candida albicans," Public Health Relevance Fungal infections cause serious opportunistic infections in immunocompromised patients, such as those infected with the Human Immunodeficiency Virus and with Acquired Immunodeficiency Syndrome (AIDS). Resistance to antifungal drugs is of particular concern given the limited number of clinically useful antifungals. The proposed work will address basic questions about how resistance arises in response to a range of antifungal drugs, with the goal of identifying potential targets for companion drugs that would extend the life span of the limited arsenal of available antifungals.",62427,ZRG1,Special Emphasis Panel,,6,422792,
7884677,R01,AI,2,,02/01/2010,01/31/2011,PA-07-070,2R01AI064721-06,,NIAID:342000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"CAPARON, MICHAEL G.;",1895716;,2R01AI064721,02/01/2005,01/31/2015,"(11)Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-; Accounting; Address; Alleles; Allelomorphs; Arthritis, Rheumatic, Acute; Binding; Binding (Molecular Function); Binding Proteins; CDC; Carbohydrates; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell membrane; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of life; Cholest-5-en-3-ol (3beta)-; Cholesterol; Complex; Cultured Cells; Cytochalasin D; Cytokine Signal Transduction; Cytokine Signaling; Cytolysins; Cytoplasmic Membrane; Cytosol; DPN hydrolase; DPNase; Data; Death; Diphosphopyridine Nucleotidase; Disease; Disorder; Endocytosis; Enzymatic Biochemistry; Enzymology; Epithelial Cells; Family; Genetic Alteration; Genetic Change; Genetic defect; Genome; Glycans; Glycohydrolases; Glycosidases; Glycoside Hydrolases; Gram-Positive Bacteria; Infection; Intracellular Communication and Signaling; Killings; Kinetic; Kinetics; Ligand Binding Protein; Lytotoxicity; Mammals, Mice; Mediating; Membrane; Mice; Modeling; Molecular Interaction; Murine; Mus; Mutation; N-terminal; NAD+ Glycohydrolase; NAD+ Nucleosidase; NADase; NH2-terminal; Network Analysis; Outcome; Pathogenesis; Pathway Analysis; Pathway interactions; Pharyngitis; Plasma Membrane; Play; Polyarthritis Rheumatica; Polysaccharides; Process; Property; Property, LOINC Axis 2; Prostaglandins; Prostanoids; Receptor Protein; Resistance; Rheumatic Fever; Rheumatism, Articular, Acute; Rheumatisms, Acute Articular; Role; S. pyogenes; S.pyogenes; Scarlet Fever; Signal Transduction; Signal Transduction Systems; Signaling; Soft Tissue Infections; Streptococcus Group A; Streptococcus pyogenes; Structure; Technology; Testing; Toxic effect; Toxicities; Toxin; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Variant; Variation; Virulence; Wound Healing; Wound Repair; base; biological signal transduction; cell behavior; cytokine; cytolysin; cytotoxic; cytotoxicity; disease/disorder; extracellular; genome mutation; inhibitor; inhibitor/antagonist; lymphocyte pore-forming protein; macrophage; member; membrane structure; mutant; necrocytosis; novel; pathogen; pathway; perforin; plasmalemma; pore forming protein; porin; public health relevance; receptor; resistant; response; retrograde transport; social role; streptolysin O; tissue repair; uptake",CYTOLYSIN-MEDIATED TRANSLOCATION IN S. PYOGENES VIRULENC," Project Narrative  Cytolysin-mediated translocation (CMT) is a novel pathway for toxin delivery in the Gram-positive pathogen Streptococcus pyogenes that uses the pore-forming cytolysin Streptolysin O (SLO) to translocate the streptococcal NAD+ glycohydrolase (SPN) across the host cell membrane and into its cytosol. Both SLO and cytosolic SPN then act to cause host cell death. In this project we will exploit our recent observations that pore-formation and glycohydrolase activity are dispensable for CMT and toxicity, respectively, along with our determination of the crystal structure of SPN to produce mutants of SPN and SLO that will be used to elucidate how SLO acts to translocate SPN. We will also use these mutants to investigate how SLO and SPN interact to both kill and manipulate the cytokine signaling responses of cells. This information will be important for understanding how the multiple toxins of S. pyogenes interact with each other and with host cells to unravel how this pathogen can cause such a diverse range of different diseases.",64721,BACP,Bacterial Pathogenesis Study Section,,6,342000,
7782978,R01,AR,2,,02/01/2010,01/31/2011,PA-07-070,2R01AR045203-11,,NIAMS:396000;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"TAPSCOTT, STEPHEN J.;",1863870;,2R01AR045203,09/01/1998,01/31/2015,"5'-Adenylic acid, homopolymer; Alleles; Allelomorphs; Apoptosis; Apoptosis Pathway; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biopsy Sample; Biopsy Specimen; Brachydanio rerio; Cell Death, Programmed; Cellular Stress; Cellular biology; Code; Coding System; D4Z4; Danio rerio; Development; Disease; Disorder; Dysfunction; Elements; Embryo; Embryonic; Facioscapulohumeral; Family; Functional disorder; Future; Gene Products, RNA; Gene Targeting; Gene Transcription; Genetic Transcription; Goals; Health; Human; Human, General; IRES; In element; Indium; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; Isoforms; Knowledge; Length; Mammals, Primates; Man (Taxonomy); Man, Modern; Measures; Messenger RNA; Modeling; Molecular; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Muscular Dystrophies; Myocytes; Myodystrophica; Myodystrophy; ORFs; Open Reading Frames; Pathology; Phase; Phenotype; Physiopathology; Poly A; Poly(A)+ RNA; Poly(A)+ mRNA; Poly(rA); Polyadenylated RNA; Polyadenylated mRNA; Polyadenylation; Primates; Production; Programs (PT); Programs [Publication Type]; Protein Coding Region; Protein Isoforms; Proteins; RNA; RNA Expression; RNA Polyadenylation; RNA Splicing; RNA, Messenger; RNA, Messenger, Polyadenylated; RNA, Non-Polyadenylated; Relative; Relative (related person); Ribonucleic Acid; Ribosome Entry Site; Role; Splicing; Stress; Study Section; Targetings, Gene; Testing; Transcript; Transcription; Transcription, Genetic; Translations; Zebra Danio; Zebra Fish; Zebrafish; base; capping of mRNA; cell biology; disease/disorder; gene product; mRNA; mRNA capping; myogenesis; pathophysiology; polyadenylate; prevent; preventing; programs; public health relevance; response; social role; therapeutic development",D4Z4 Coding Transcripts and FSHD, PROJECT NARRATIVE The human health relatedness of this proposal is that it will identify possible molecular causes of FSHD and provide a basis for future therapeutic development.,45203,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,11,396000,
7781820,R01,AR,2,,01/30/2010,12/31/2010,PA-07-070,2R01AR049010-06A1,,NIAMS:334125;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LEXINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"CROFFORD, LESLIE J;",1892812;,2R01AR049010,07/01/2002,12/31/2014,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; 11-Dehydroprostaglandin F2 alpha; 11-Dehydroprostaglandin F2alpha; 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))-; Acute; Alprostadil; Anabolism; Aneurysm; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antigen Presentation; Antiinflammatories; Antiinflammatory Agents; Arachidonic Acid Cyclooxygenase; Arachidonic Acids; Arthritis; Astra Brand of Alprostadil; Atrophic Arthritis; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; Autoregulation; Back; Biology; Bizzozero's corpuscle/cell; Blood Platelets; Blood Serum; Blood Vessels; Body Tissues; Bone Marrow; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; COX; COX-1; COX-1 protein; COX-2 protein; COX1; COX2; COX2 enzyme; COX2 inhibitor; COX3; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Caverject; Cell Function; Cell Process; Cell Surface Receptors; Cell physiology; Cell surface; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Chimera; Chimera organism; Clinical; Clinical Data; Clinical Trials; Clinical Trials, Unspecified; Collagen; Collagen Arthritis; Collagen Type II; Collagen-Induced Arthritis; Coxibs; Cyclo-Oxygenase; Cyclo-Oxygenase-1; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Cyclooxygenase 3; Cytokine Signal Transduction; Cytokine Signaling; Data; Deetjeen's body; Dendritic Cells; Development; Dinoprostone; Disease; Disorder; Dorsum; Drugs; EC 3.1.1.4; Effectiveness; Effector Cell; Eicosanoids; Embryo; Embryonic; Enzymes; Epoprostenol; Equilibrium; Event; Exhibits; FLR; Failure (biologic function); Fatty Acid Cyclo-Oxygenase; Fatty Acid Cyclooxygenase; Fever; Fibroblasts; Generations; Genetic; Goals; Hayem's elementary corpuscle; Hematopoietic; Hepatocyte Nitric Oxide Synthase; Homeostasis; Human; Human, General; Hydroperoxide Cyclase; Hyperthermia; INFLM; INOS; Immune; Immune response; Immunity; Immunomodulation; Inducible Nitric Oxide Synthase; Inflammation; Inflammatory; Inflammatory Arthritis; Inflammatory Response; Isoforms; Janssen Brand of Alprostadil; K/BxN model; Knockout Mice; LTB4; Lead; Learning; Lecithinase A2; Leukotriene B-4; Leukotriene B4; Lipids; Lipo-PGE1; Literature; Lymphocyte; Lymphocytic; MHC Receptor; MMPs; Macrophage Nitric Oxide Synthase; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow platelet; Matrix Metalloproteinases; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrana Synovialis Capsulae Articularis; Mesenchymal; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Murine; Mus; Muse; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide Synthase 2A; Null Mouse; Organ System, Cardiovascular; PGD2; PGE synthase 1, mouse; PGE1; PGE1alpha; PGE2; PGE2 alpha; PGE2 isomerase; PGE2alpha; PGH Synthase; PGH Synthase 1; PGH Synthase 2; PGH(2); PGH2; PGH2 Synthetase; PGHS-1; PGHS-2; PGHS2; PGI2; PGR2 E-isomerase; PGX; PHS II; PHS1; PLA2; PPAR; PTGS1; PTGS2; Pain; Painful; Pb element; Peroxisome Proliferator-Activated Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphatides; Phospholipase A2; Phospholipids; Physiological Homeostasis; Platelets; Play; Process; Production; Property; Property, LOINC Axis 2; Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9alpha,13E,15S)-; Prostacyclin; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin D2; Prostaglandin E1; Prostaglandin E1alpha; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin G/H Synthase 1; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H Synthase; Prostaglandin H2; Prostaglandin H2 Synthase; Prostaglandin H2 Synthase 1; Prostaglandin H2 Synthase 2; Prostaglandin H2 Synthetase; Prostaglandin I(2); Prostaglandin I2; Prostaglandin Production; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; Protein Isoforms; Pyrexia; RNA, Small Interfering; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Regulatory T-Lymphocyte; Resistance; Resolution; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Platelets; Rheumatoid Arthritis; Risk; Role; Serum; Shunt; Shunt Device; Small Interfering RNA; Stimulus; Subcellular Process; Swelling; Synovial Membrane; Synovium; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Therapeutic; Therapeutic Intervention; Thrombocytes; Thymus-Dependent Lymphocytes; Tissues; Toxic effect; Toxicities; Transgenic Mice; Translating; Translatings; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular, Heart; Veiled Cells; Work; analog; arthritic; balance; balance function; base; biosynthesis; cell type; circulatory system; clinical investigation; cyclo-oxygenase I; cyclo-oxygenase II; cyclooxygenase 1; cyclooxygenase 2; cytokine; disease/disorder; drug/agent; endoperoxide isomerase; expectation; experiment; experimental research; experimental study; failure; febrile; febris; gastrointestinal; heavy metal Pb; heavy metal lead; helper T cell; hematopoietic tissue; his-PG; host response; human NOS2A protein; iNOS enzyme; immune modulation; immunologic reactivity control; immunoregulation; immunoresponse; inhibitor; inhibitor/antagonist; insight; intervention therapy; language translation; lecithinase A; lymph cell; mPGES-1; mouse PGE synthase 1; nitric oxide synthase, Type II; peripheral blood; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; pre-clinical; preclinical; progesterone 11-hemisuccinate-(2-iodohistamine); prostaglandin E isomerase; prostaglandin E synthase; prostaglandin E2 isomerase; prostaglandin H synthase-1; prostaglandin H synthase-2; prostaglandin H2 E-isomerase; prostaglandin H2-prostaglandin E2 isomerase; prostaglandin R2 E-isomerase; prostaglandin X; prostaglandin endoperoxide E isomerase; public health relevance; research study; resistant; response; self recognition (immune); shunts; siRNA; social role; therapeutic target; thrombocyte/platelet; thymus derived lymphocyte; vascular",Microsomal Prostaglandin E Synthase in Rheumatoid Arthritis," PROJECT NARRATIVE The discovery of COX-2 and subsequent development of specific COX-2 inhibitors represented an enormous conceptual advance in eicosanoid biology and opened new possibilities for pharmacologic treatment of inflammation and pain. It is clear, however, that COX-2-specific NSAIDs have their own toxicities. The finding of a PGE synthase isoform induced during inflammation and required for high level PGE2 production represents a conceptual advance of similar magnitude. In view of the existence of multiple PGES enzymes and other PG subclasses, the specific role of mPGES-1-derived PGE2 in inflammation and autoimmunity remains uncertain. Furthermore, information on the biology that will inform the development of mPGES-1 as a therapeutic target remains incomplete. It is our expectation that our work will yield new insights into the role of PGs in the functioning of eicosanoids during initiation and resolution of inflammation and the transition from the innate to the acquired immune response.",49010,ACTS,"Arthritis, Connective Tissue and Skin Study Section",A1,6,334125,
7782597,R01,AT,2,,02/01/2010,11/30/2010,PA-07-070,2R01AT001424-05A2,,NCCAM:349501;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,GAINESVILLE,UNITED STATES,OTHER HEALTH PROFESSIONS,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"ROBINSON, MICHAEL EDWARD;",1868423;,2R01AT001424,03/15/2003,11/30/2014,"Absence of pain sensation; Absence of sensibility to pain; Accounting; Address; Affective; American; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Anterior; Antinociceptive Agents; Antinociceptive Drugs; Anxiety; Behavioral; Bilateral; Biological Neural Networks; Brain; Brain imaging; Brain region; Central Lobe; Characteristics; Client satisfaction; Clinical; Cognitive; Data; Dimensions; Encephalon; Encephalons; Equation; Esthesia; Factors, Psychological; Feedback; Feels no pain; Functional Magnetic Resonance Imaging; Funding; Fusiform gyrus; Goals; Gyrus Hippocampi; Gyrus Parahippocampalis; Hippocampal Gyrus; Hypothalamic structure; Hypothalamus; Insula; Insula of Reil; Island of Reil; Knowledge; Lead; Left; MRI, Functional; Magnetic Resonance Imaging, Functional; Medial; Methods and Techniques; Methods, Other; Middle Temporal Gyrus; Modeling; Nervous System, Brain; Network Analysis; No sensitivity to pain; Occipital-Temporal Gyrus; Outcome; PBO; Pain; Painful; Parahippocampal Gyrus; Pathway Analysis; Patient Satisfaction; Pattern; Pb element; Placebos; Population; Prefrontal Cortex; Process; Protocol; Protocols documentation; Psychological Factors; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Research; Sensation; Sensory; Sham Treatment; Somatosensory Cortex; Stimulus; Structure; Structure of middle temporal gyrus; Techniques; Temporal Lobe; Thalamic structure; Thalamus; Time; Visit; Work; amygdaloid nuclear complex; analgesia; brain visualization; cingulate cortex; expectation; experience; fMRI; frontal cortex; frontal lobe; heavy metal Pb; heavy metal lead; hypothalamic; improved; information processing; neural network; neuroimaging; psycho-physiological; psychologic; psychological; public health relevance; sham therapy; somatosensory; somesthetic sensory cortex; success; temporal cortex; temporal lobe/cortex; thalamic; tool",Brain Imaging and Pain: Analysis of Placebo Analgesia," Nearly 1 in 5 Americans suffers from a pain condition. This research addresses the need to understand the structure and function of the neural networks that process and modulate pain. A more robust understanding of endogenous pain modulation will ultimately lead to enhanced treatments, patient satisfaction, and outcomes of pain conditions.",1424,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",A2,5,349501,
7883968,R01,CA,2,,02/01/2010,12/31/2010,PA-07-070,2R01CA030002-29,,NCI:396128;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"ROBERTS, THOMAS M;",1884511;,2R01CA030002,02/01/1982,12/31/2014,"(2,6)-sialyl T antigen; 1-Phosphatidylinositol 3-Kinase; 14-3-3 Proteins; ATGN; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Ablation; Active Follow-up; Adverse effects; Antigens; BZS; Binding Proteins; Biochemical; Bittner Virus; Body Tissues; Brain 14-3-3 Protein; Breast; Breast Cancer Model; Bypass; Cancer Genes; Cancer Model; Cancer Treatment; Cancer of Prostate; Cancer-Promoting Gene; CancerModel; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Components; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Structure; CellLine; Cells; Cellular Structures; Characteristics; Chemicals; Chemopreventive; Chemopreventive Agent; Chimp; Chimpanzee; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Complex; Crossmatching, Tissue; Cytokines, Chemotactic; Data; Dependence; Drugs; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Enzymes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Familiar Malignant Neoplasm; Family; Frequencies (time pattern); Frequency; Future; Generations; Genetic; Genital System, Male, Prostate; Genomics; Grant; HEK3; Hereditary Cancer; Hereditary Malignant Neoplasm; Histocompatibility Testing; Homologous Chemotactic Cytokines; Human; Human Prostate; Human Prostate Gland; Human, General; Individual; Infiltration; Intercrines; Intracellular Communication and Signaling; Isoforms; Kinases; Knock-out; Knockout; Laboratories; Lesion; Ligand Binding Protein; Lipids; MHAM; MMAC1; MMTV; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Mammary Cancer Virus; Mammary Tumor Virus, Mouse; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Modeling; Molecular; Mouse Mammary Tumor Virus; Murine; Mus; Nature; Oncogenes; Oncogenesis; Oncogenic; PI-3 Kinase; PI-3K; PI3-Kinase; PI3-Kinase Inhibitors; PI3CG; PI3KGamma; PI3k; PIK3; PIK3CG; PIK3CG gene; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTEN; PTEN gene; PTEN1; PTK; PTK Receptors; PTPA; Pan; Pan Genus; Pan Species; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatase and Tensin Homolog; Phosphatidylinositide 3-Kinase Inhibitor; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Phosphotyrosyl Phosphatase Activator; Play; Polyoma; Polyoma Viruses; Polyomavirus; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Protein Family; Protein Isoforms; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; PtdIns 3-Kinase; Public Health; RTK; Receptor Protein-Tyrosine Kinases; Relative; Relative (related person); Resistance; Role; SIS cytokines; ST antigen; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Speed; Speed (motion); Stealing; Stealings; T Antigens; Technology; Theft; Therapeutic; Time; Tissue Crossmatchings; Tissue Typing; Tissues; Transforming Genes; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Treatment Side Effects; Tumor of the Prostate; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Viral Oncogene; Viral T Antigens; Viral Tumor Antigens; Virus; Virus Transforming Antigens; Viruses, General; Work; anticancer therapy; anticarcinogenic; antigen binding; base; biological signal transduction; cancer therapy; cell transformation; chemoattractant cytokine; chemokine; clinical investigation; cultured cell line; drug/agent; experiment; experimental research; experimental study; familial cancer; follow-up; histocompatibility typing; hydroxyaryl protein kinase; immunogen; inhibitor; inhibitor/antagonist; insulin signaling; kinase inhibitor; malignancy; mammary cancer model; mammary tumor model; milk agent; neoplasm/cancer; new technology; pathway; public health medicine (field); public health relevance; research study; resistant; s-T antigen; sialosyl-T antigen; side effect; social role; therapy adverse effect; transformed cells; treatment adverse effect; tumor; tumor initiation; tumorigenesis; tyrosyl protein kinase",Molecular Mechanisms of Polyoma Induced Transformation," Relevance to Public Health The first generation of PI3 Kinase inhibitors are just now entering clinical trials. The experiments proposed in this grant use murine tumor models driven by the viral oncogene MT antigen to (1) speed the use of second generation isoform specific PI3K inhibitors by determining how best to target individual PI3 Kinase isoforms in various tumor types, (2) investigate the potential of PI3K inhibitors as chemopreventatives and (3) determine how tumors may become resistant to PI3K inhibitors. Each of these aims has considerable potential to facilitate therapy for a number of important human tumor types.",30002,VIRA,Virology - A Study Section,,29,396128,
7783353,R01,CA,2,,02/01/2010,12/31/2010,PA-07-070,2R01CA039687-23A1,,NCI:294178;,2010,NATIONAL CANCER INSTITUTE,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"MORAN, RICHARD G;",1865250;,2R01CA039687,09/30/1985,12/31/2014,"2,4-Dioxo-5-fluoropyrimidine; 4-Amino-10-methylfolic Acid; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; 5-FU; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-Fluorouracil; 5-Fluracil; 5-Formyl-5,6,7,8-tetrahydrofolic Acid; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid; 5FU; Accounting; Address; Antifolates; Antimetabolites; Applications Grants; Area; Binding; Binding (Molecular Function); Binding Sites; Blood (Leukemia); Body Tissues; Cancer Treatment; Cancers; Catalysis; Cells; Characteristics; Clinical; Combining Site; Complex; Development; Drug-sensitive; Drugs; Enzymatic Biochemistry; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Enzymology; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Experimental Designs; Feedback; Fluoro Uracil; Fluorouracil; Fluoruracil; Fluouracil; Folate; Folate Analog; Folate Inhibitors; Folate Metabolism; Folic Acid Analog; Folic Acid Antagonists; Folic Acid Inhibitors; Folic Acid Metabolosm; Folinic Acid; Folinic Acid-SF; Folylpolyglutamate synthase; Gene Transcription; Genes; Genetic Transcription; Genetics-Mutagenesis; Glutamate Ammonia Ligase (ADP); Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine Synthetase; Grant; Grant Proposals; Grants, Applications; Hematopoietic; Human; Human, General; Individual; L-Glutamate[{..}]ammonia ligase (ADP-forming); L-Glutamic Acid; L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl); L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-; L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; L-Leucovorin; LEUKCL; Laboratories; Lead; Leucovorin; Leukemias, General; Leukemic Cell; Leukovorum; Levofolinic acid; Levoleucovorin; MTA; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Methotrexate; Methotrexate Methylaminopterin; Methotrexatum; Metotrexato; Mice; Mitochondria; Modeling; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mother Cells; Multitargeted Antifolate; Murine; Mus; Mutagenesis; N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid; N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid; N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid; Naturally Occurring Folate; Pattern; Pb element; Pemetrexed; Pemetrexed (Alimta) (LY231514); Peptide/Protein Chemistry; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology; Polyglutamate Folates; Population; Process; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Chemistry; Pteridines; Pteroylpolyglutamates; Pyrazinopyrimidines; RNA Expression; Reactive Site; Reagent; Recombinants; Series; Site; Stem cells; Structure; Tetrahydrofolates; Therapeutic; Thermodynamic; Thermodynamics; Time; Tissues; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Tumor Cell; Work; analog; anticancer therapy; base; cancer therapy; cell type; chemotherapy; citrovorum; cofactor; design; designing; drug development; drug/agent; experiment; experimental research; experimental study; folate antagonist; folic acid metabolism; folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthetase; glutamate synthetase; glutamine synthase; heavy metal Pb; heavy metal lead; leukemia; malignancy; man; man's; mitochondrial; neoplasm/cancer; neoplastic cell; polyglutamate; polyglutamates; public health relevance; research study; tetrahydrofolylpolyglutamate synthase; tumor",Human Folylpolyglutamate Synthetase and Cancer Therapeutics," Narrative The grant application proposes experiments that would lead to an understanding of how human folylpolyglutamate synthetase, an enzyme that limits the accumulation of folate compounds and analogs used for cancer therapy, carries out its functions. This enzyme determines whether individual human tumors are sensitive or insensitive to therapy with the antifolate drugs methotrexate, ralitrexid, and pemetrexed, and also the 5-fluoruracil- leucovorin combination. All of these drugs are currently used for treatment of human cancers, so any enhancement in our understanding of the enzyme that serves as a limitation for drug effects would help us design more rational cancer treatments with these drugs.",39687,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,A1,23,294178,
7783198,R01,CA,2,,05/01/2010,02/28/2011,PA-07-070,2R01CA068051-15,,NCI:469785;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"WANG, FREDERICK C.;",1887980;,2R01CA068051,07/01/1995,02/28/2015,"21+ years old; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acute; Adult; Animal Model; Animal Models and Related Studies; Biological Models; Burkitt Herpesvirus; Burkitt Lymphoma; Burkitt Lymphoma Virus; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; CTL; Cancers; Carcinoma of Nasopharynx; Cell-Mediated Lympholytic Cells; Cloning, Molecular; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Defect; E-B Virus; EB virus; EBV; EBV Infections; EBV-associated disease; EBV-associated malignancy; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus Infections; Epstein-Barr Virus associated disease; Epstein-Barr Virus associated malignancy; Epstein-Barr pathogenesis; Gastric Cancer; Gastric Carcinoma; Genes; Glandular Fever; Goals; HHV-4; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Human; Human Herpes Virus 4 Infections; Human Herpesvirus 4; Human Herpesvirus 4 Infections; Human, Adult; Human, General; ITX; Immune; Immune response; Immunity; Immuno-Chemotherapy; Immunochemotherapy; Immunologic Deficiency Syndrome, Acquired; Immunologic Monitoring; Immunologically Directed Therapy; Immunosurveillance; Immunotherapy; Immunotherapy, Cancer, General; Infection; Infectious Mononucleosis; Infectious Mononucleosis Virus; Lymphocryptovirus; Lymphogranuloma, Malignant; Lymphoproliferative Disorders; Macaca; Macaca mulatta; Macaque; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Model System; Models, Biologic; Molecular Cloning; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; Pathogenesis; Patients; Population; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Stomach Cancer; Stomach Carcinoma; System; System, LOINC Axis 4; T-Lymphocytes, Cytotoxic; Translating; Translatings; Transplantation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; adult human (21+); cancer immunotherapy; effective therapy; host response; human disease; human herpesvirus 4 group; immune therapy; immunoresponse; improved; language translation; lymphogranulomatosis; lymphogranulomatosis (malignant); lymphoproliferative disease; malignancy; model organism; mononucleosis; neoplasm/cancer; pathogenesis of Epstein-Barr virus; pathogenesis of Epstein-Barr virus infection; programs; public health relevance; social role; transplant; virus host interaction; virus protein",Pathogenesis of EBV Infection," Project Narrative/Public Health Relevance  Epstein-Barr virus persistently infects 95% of the adult population, is the most common cause of infectious mononucleosis, and is associated with various malignancies including lymphoproliferative disease in post-transplant and AIDS patients, Nasopharyngeal Carcinoma, Burkitt Lymphoma, Hodgkin Lymphoma and gastric carcinoma. This research project focuses on virus-host interactions in the context of complete, natural hosts in order to better understand how Epstein-Barr virus (EBV) successfully infects humans, how it causes human disease, and how effective therapies against EBV-associated cancers can be developed.",68051,VIRB,Virology - B Study Section,,15,469785,
7917800,R01,CA,2,,03/01/2010,12/31/2010,PA-07-070,2R01CA081135-12,,NCI:301267;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"MUNGER, KARL ;",1959358;,2R01CA081135,02/15/2000,12/31/2014,"Active Follow-up; Aerobic; Affect; Anal; Anus; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Autophagocytosis; Bioassay; Biologic Assays; Biological; Biological Assay; Blood (Leukemia); Blood Serum; Cancer Cause; Cancer Etiology; Cancer Genes; Cancer Induction; Cancer of Cervix; Cancer of the Penis; Cancer of the Uterine Cervix; Cancer-Promoting Gene; Cancers; Carcinoma; Carcinoma Cell; Carcinoma of the Uterine Cervix; Cell Communication and Signaling; Cell Cycle Arrest; Cell Death; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell-Death Protease; Cells; Cellular Proliferation; Cervical Cancer; Cervical Carcinoma; Cervix Cancer; Cervix Uteri Carcinoma; Cervix carcinoma; Cessation of life; Chromosomes; Clinic; Commit; Conflict; Conflict (Psychology); Death; Death Rate; EC 2.7; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Equilibrium; Event; External Genitalia; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fermentation; Fibroblasts; GFAC; Generalized Growth; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genomics; Gleevec; Glivec; Glycolysis Inhibition; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HPV; HPV 16; HPV Vaccine; HPV-16; HPV-High Risk; HPV16; High risk HPV; High risk Human Papillomavirus; High risk Human papilloma virus; Human; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus Vaccine; Human papillomavirus type 16; Human papillomavirus, type 16; Human, General; ICE-like protease; Incidence; Infection; Infectious Human Wart Virus; Intracellular Communication and Signaling; Kinases; Lead; Lesion; Leukemias, General; Life Cycle; Life Cycle Stages; Malignant; Malignant - descriptor; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Epithelial Cell; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Penile Neoplasm; Malignant Penile Tumor; Malignant Tumor; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Tumor of the Mouth; Malignant Tumor of the Penis; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of cervix uteri; Malignant neoplasm of mouth; Malignant neoplasm of penis; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Metabolic stress; Modality; Molecular; Mortality; Mortality Vital Statistics; Mouth Cancer; Mutation; Normal Cell; Normal Tissue; Normal tissue morphology; Oncogene Activation; Oncogene Products; Oncogene Proteins; Oncogenes; Oncogenic; Oncoproteins; Oral Cancer; P53; PDZ protein; Papilloma Virus, Human; Papillomavirus, Human; Pathway interactions; Pb element; Penile Cancer; Penis Cancer; Peptide Domain; Philadelphia; Phosphotransferases; Pre-Malignant; Premalignant; Protein Binding; Protein Domains; Publications; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Relative; Relative (related person); Reporting; Scientific Publication; Sentinel; Serum; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Solid Neoplasm; Solid Tumor; TP53; TP53 gene; TRP53; Tertiary Protein Structure; Testing; Therapeutic; Tissue Growth; Transforming Genes; Transphosphorylases; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Vaccination; Vaccines; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Vulva; Warburg Effect; Woman; Work; addiction; autophagy; balance; balance function; base; biological signal transduction; cancer progression; carcinogenesis; caspase; cell suicide; cellular suicide; cellular targeting; cystein protease; cystein proteinase; cysteine endopeptidase; defense response; deprivation; detection of nutrient; epithelial carcinoma; experience; experiment; experimental research; experimental study; follow-up; genome mutation; heavy metal Pb; heavy metal lead; human FRAP1 protein; human papilloma virus 16; inhibitor; inhibitor/antagonist; keratinocyte; kinase inhibitor; leukemia; life course; mTOR; mTOR Inhibitor; mTOR inhibition; malignancy; malignant mouth neoplasm; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic progression; new therapeutics; next generation therapeutics; novel therapeutics; nutrient sensing; ontogeny; pathway; perception of nutrients; precancerous; prophylactic; protein expression; protein protein interaction; public health relevance; rapamycin and FKBP12 target 1 protein, human; research study; response; senescence; sensor; small molecule; tissue culture; tumor progression; tumor suppressor; virus protein; wart virus",MODULATION OF HOST CELL APOPTOTIC RESPONSES BY HPVE7," Project Narrative Infections with high-risk human papillomaviruses (HPVs) have been associated with a variety human cancers, including cervical carcinoma, the second most common cause of cancer death in women worldwide. Despite the recent introduction of a prophylactic HPV vaccine, it will be decades before such vaccination will decrease incidence and mortality of cervical cancer and more than 10 women will succumb to HPV-associated cervical cancer in the US every day for the next several decades. The focus of this proposal is to determine the molecular mechanisms by which HPV16 E7 oncoprotein expression predisposes cells to commit cellular suicide, to delineate the mechanism by which the E6 oncoprotein holds this E7 activity in check and to perform proof of principle experiments with small molecule inhibitors that are already in the clinic to determine whether this dormant cell death response may be harnessed as a therapeutic modality for HPV-associated lesions and cancers.",81135,ZRG1,Special Emphasis Panel,,12,301267,
7842047,R01,CA,2,,01/25/2010,12/31/2010,PA-07-455,2R01CA082036-11A2,,NCI:397221;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"KAYE, KENNETH M;",1898090;,2R01CA082036,07/01/1999,12/31/2014,"ADP-Ribosyltransferase (Polymerizing); AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Amino Acids; Area; Binding; Binding (Molecular Function); Biochemical; Biology; C-terminal; Cancers; Cell Nucleus; Cells; Chromosomes; Clinical; DNA; DNA Binding; DNA Binding Interaction; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Viral; Daughter; Deoxyribonucleic Acid; Development; Disease; Disorder; Drugs; EFF; Episome; Flanking Repeat Sequences; Future; Genes; Genetic; Germinoblastoma; HHV-8; HHV8; Herpesviridae Infections; Herpesviridae disease; Herpesvirus Infections; Histone H2A; Human; Human, General; Immune response; Immunologic Deficiency Syndrome, Acquired; Investigation; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Knowledge; LANA (antigen); Lead; Light; Link; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lytic; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Medication; Mitotic Chromosome; Molecular Interaction; Multicentric Angiofollicular Lymphoid Hyperplasia; Multicentric Castleman's Disease; Multiple Hemorrhagic Sarcoma; N-terminal; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; NH2-terminal; Nucleus; ORF73 gene product; PARP Polymerase; PARS; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Preventive; Process; Proliferating; Proteins; Racial Segregation; Reticulolymphosarcoma; Risk; Role; Sarcoma, Germinoblastic; Terminal Repeat; Terminal Repeat Sequences; Therapeutic; Tumor Cell; Viral; Viral Latency; Virus Latency; Virus-HHV8; Work; aminoacid; antigen binding; disease/disorder; drug/agent; effusion; gene product; heavy metal Pb; heavy metal lead; host response; human herpesvirus 8; immunoresponse; inhibitor; inhibitor/antagonist; insight; latency-associated nuclear antigen; latent infection; malignancy; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; novel; novel therapeutics; poly ADP polymerase; poly ADP ribose synthetase; prevent; preventing; public health relevance; response; segregation; small molecule; social role; tool; tumor; viral DNA; virus DNA",Genetic and Biochemical Studies of the KSHV LANA Gene, Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) has a causative role in several human malignancies. KSHV infects and persists in tumor cells. This work investigates the mechanisms by which KSHV is able to persist and survive in the tumor cells. A better understanding of this viral persistence may allow development of strategies which prevent or treat KSHV tumors.,82036,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,A2,11,397221,
7779658,R01,CA,2,,02/01/2010,01/31/2011,PA-07-070,2R01CA083859-09A1,,NCI:306759;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,064367329,US,PA,191112434,INSTITUTE FOR CANCER RESEARCH,"CAMPBELL, KERRY S;",1938125;,2R01CA083859,12/01/1999,01/31/2015,"2-hydroxyphenylalanine; 2-tyrosine; ADCC; AP-2; AP-2 Alpha; AP-2 Alpha Protein; AP2; AP2 Protein; AP2 Transcription Factor; AP2TF Protein; Activating Enhancer-Binding Protein 2-Alpha; Activator Protein 2; Adaptor Protein; Adaptor Signaling Protein; Address; Affect; Antibodies, Enhancing; Antibody -dependent cell cytotoxicity; Antibody-Dependent Cellular Cytotoxicity; Autoimmune Responses; BPTP3; Binding; Binding (Molecular Function); CFC; CTL; Cell Body; Cell Communication and Signaling; Cell Cytoxicity, Antibody-Dependent; Cell Line; Cell Lines, Strains; Cell Signaling; Cell membrane; Cell surface; Cell-Mediated Lympholytic Cells; CellLine; Cells; Class I Antigens; Class I Major Histocompatibility Antigens; Clathrin; Clathrin Adaptors; Clathrin Assembly Proteins; Clathrin-Associated Adaptors; Clathrin-Associated Proteins; Complex Class 1; Cytolytic T-Cell; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Cytosolic Protein Tyrosine Phosphastase; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; Data; E3 Ligase; E3 Ubiquitin Ligase; Endocytosis; Enhancing Antibodies; Equilibrium; Event; Family; Fc Receptor; FcR; Future; Goals; HCP; HCPH; HLA-A; HLA-A gene; HLAA; HPTP1C; Hematopoietic Cell Protein Tyrosine Phosphatase; Histocompatibility Antigens Class I; Histocompatibility Complex; Histocompatibility Complices; Human; Human, General; ITIM; Immunoreceptor Tyrosine-Based Inhibitory Motif; Intracellular Communication and Signaling; K Cells; K lymphocyte; Killer Cells; L-Serine; L-Threonine; L-Tyrosine; Ligands; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; Major Histocompatibility Complex; Major Histocompatibility Complex Class 1; Major Histocompatibility Complices; Man (Taxonomy); Man, Modern; Mediating; Membrane Protein Traffic; Membrane Traffic; Molecular; Molecular Interaction; NK Cell Activation; NK Cells; NS1; Natural Killer Cell Activation; Natural Killer Cells; Normal Cell; Oncogenic Viruses; PTP-1C; PTP-1D; PTP2C; PTPN11; PTPN11 gene; PTPN6; PTPN6 gene; PTPN6 protein, human; PTPase; Pathway interactions; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Plasma Membrane; Protein Phosphorylation; Protein Tyrosine Phosphatase; Protein Tyrosine Phosphatase SHP-1; Proteins; Public Health; Publications; Receptor Protein; Receptor Signaling; Recruitment Activity; Recycling; Regulation; Role; SH-PTP1; SH-PTP2; SH-PTP3; SH2 Domains; SHP-1; SHP-1L; SHP-2; SHP2; Scientific Publication; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Surface; T-Lymphocytes, Cytotoxic; TFAP2 Protein; TFAP2A; TFAP2A Protein; TFAP2alpha protein; TYR; Testing; Therapeutic; Threonine; Transcription Factor AP-2 Alpha; Tumor Cell; Tumor Viruses; Tyrosine; Tyrosine Phosphatase; Tyrosine, L-isomer; Tyrosyl Phosphoprotein Phosphatase; Ubiquitin-Protein Ligase E3; Viral; Virus; Viruses, General; Work; antibody dependent cell mediated cytotoxicity; antibody receptor; arrestin 2; balance; balance function; biological signal transduction; cell body (neuron); cultured cell line; cytokine; experiment; experimental research; experimental study; gene product; human PTPN6 protein; improved; inhibitory surface receptor; mutant; neoplastic cell; neural cell body; neuronal cell body; new therapeutic target; ortho-tyrosine; para-Tyrosine; pathway; plasmalemma; protein tyrosine phosphate phosphohydrolase; public health medicine (field); public health relevance; receptor; receptor expression; receptor function; receptor internalization; recruit; research study; response; social role; soma; src Homology Region 2 Domain; trafficking; transcription factor AP-2 alpha protein; transcription factor AP-2alpha; tumor; ubiquitin-protein ligase",Molecular Regulation of Inhibitory Killer Cell Ig-like Receptors," Relevance to Public Health Natural killer (NK) cells can attack tumors and virus-infected cells, and their activation state is controlled by a balance of signals from activating and inhibitory receptors. Inhibitory killer cell Ig-like receptors (KIR) are key regulators on human NK cells that establish tolerance toward normal cells of the body, but surprisingly little is known about the mechanisms that maintain their surface expression. The studies proposed in this application will characterize the molecular regulation of KIR membrane trafficking to develop strategies for reducing their surface expression and thereby potentiating NK cell responses toward tumors and viruses.",83859,III,Innate Immunity and Inflammation Study Section,A1,9,306759,
7785621,R01,CA,2,,02/01/2010,12/31/2010,PA-07-070,2R01CA084628-18,,NCI:671830;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"DEPINHO, RONALD ANTHONY;",1867055;,2R01CA084628,01/01/2000,12/31/2014,"Aberrant Chromosome; Abnormalities, Chromosomal; Address; Age; Aging; Aging Process; Aging-Related Process; Alleles; Allelomorphs; Animals; Area; Autoregulation; Binding; Binding (Molecular Function); Biogenesis; Biological; Biological Models; Biology; Blood Precursor Cell; Body Tissues; Brain; Cancer Induction; Cancer Treatment; Cancers; Cardiac; Cardiomyopathies; Cause of Death; Cell Aging; Cell Communication and Signaling; Cell Senescence; Cell Signaling; Cellular Aging; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Complex; Coupled; Cytogenetic Aberrations; Cytogenetic Abnormalities; DNA Damage; DNA Injury; Data; Degenerative Disorder; Deterioration; Development; Divorce; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Dysfunction; Elements; Employee Strikes; Encephalon; Encephalons; Epithelial; Event; Exhibits; Expression Profiling; Expression Signature; Extinction; Extinction (Psychology); Fasting; Foundations; Functional disorder; Funding; Genes; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genomic Instability; Genomics; Germinoblastoma; Gluconeogenesis; Goals; Grant; Health; Heart; Hematopoietic; Hematopoietic stem cells; Hepatic; Hepatic Cirrhosis; Hereditary; Homeostasis; Human; Human, General; In element; Indium; Inherited; Intracellular Communication and Signaling; Investigation; Knock-in; Knock-in Mouse; Knockout Mice; Laboratories; Lead; Length of Life; Link; Liver; Liver Cirrhosis; Liver Stem Cell; Longevity; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Mitotic; Model System; Modeling; Models, Biologic; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Mother Cells; Murine; Mus; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; NF-E2-related factor 1; NRF-1; Nature; Neoplasm Metastasis; Neoplasms; Nervous System, Brain; Nuclear Receptors; Null Mouse; Organ; Organ System; Origin of Life; P53; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiological Homeostasis; Physiopathology; Play; Principal Investigator; Production; Progenitor Cell Transplantation; Progenitor Cells; Progenitor Cells, Hematopoietic; Progeria, Adult; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA-Binding Proteins; Regenerative Medicine; Regulation; Rejuvenation; Repression; Reserve Stem Cell; Resolution; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Secondary Neoplasm; Secondary Tumor; Senescence; Senescence, Cellular; Senescence, Replicative; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stem Cell Transplantation; Stem cell transplant; Stem cells; Stress; Strikes; Strikes, Employee; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Telomerase; Telomerase inhibition; Therapeutic; Tissues; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Translations; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Tumors; Werner Syndrome; Werner's syndrome; Work; age dependent; age related; aged; anticancer therapy; base; behavioral extinction; biological adaptation to stress; biological signal transduction; blood glucose regulation; body system; body system, hepatic; cancer cell; cancer genome; cancer genomics; cancer metastasis; cancer progression; cancer therapy; carcinogenesis; degenerative condition; degenerative disease; drug/agent; experience; fasted; fasts; frailty; gastrointestinal; genome mutation; glucose biosynthesis; glucose control; glucose homeostasis; glucose regulation; heavy metal Pb; heavy metal lead; in vivo; life span; lifespan; malignancy; mitochondrial; mitochondrial dysfunction; molecuar profile; molecular signature; mutant; myocardium disorder; neoplasia; neoplasm progression; neoplasm/cancer; neoplastic growth; neoplastic progression; novel; nrf1 protein; organ system, hepatic; pathophysiology; pathway; programs; public health relevance; reaction; crisis; regenerative; resistance mechanism; resistant mechanism; response; senescence; senescent; sensor; social role; stem cell division; stress response; stress; reaction; telomere; transcription factor; transcriptomics; tumor; tumor progression; tumor suppressor","Telomerase in Development, Senescence and Neoplasia"," Telomere dysfunction is one of the hallmark of aging, degenerative diseases and cancer. We will validate the principal of telomerase extinction as an anti-cancer therapy and define potential resistance mechanisms which should lead to new drugs that may synergize with anti-telomerase therapy.",84628,CAMP,Cancer Molecular Pathobiology Study Section,,18,671830,
7791632,R01,CA,2,,01/15/2010,11/30/2010,PA-07-070,2R01CA098803-06A1,,NCI:2105062;,2010,NATIONAL CANCER INSTITUTE,,TAMPA,UNITED STATES,,11,139301956,US,FL,336129497,H. LEE MOFFITT CANCER CTR & RES INST,"GIULIANO, ANNA R;",1876606;,2R01CA098803,01/01/2003,11/30/2014,"Active Follow-up; Address; Age; Anogenital venereal warts; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Behavioral; Biological; Biopsy; Biopsy Sample; Biopsy Specimen; Brazil; Cancer of the Penis; Cancerous; Case Series; Categories; Circumcision; Clinical; Cohort Studies; Concurrent Studies; Condom; Condoms, Unspecified; Condyloma Accuminata; Condylomata Acuminata; Country; DNA; Data; Deoxyribonucleic Acid; Detection; Development; Disease; Disease Progression; Disorder; Effectiveness; Evaluation; Future; Genital; Genital system; Goals; HHV-2; HPV; HPV 16; HPV Vaccine; HPV capsid antibodies; HPV-16; HPV16; HSV-2; HSV2; Herpes Simplex Virus 2; Herpes Simplex Virus Type 2; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus progenitalis; Histologic; Histologically; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human Papilloma Virus Vaccine; Human Papillomavirus; Human herpes simplex virus type 2; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus Vaccine; Human papillomavirus type 16; Human papillomavirus, type 16; Humoral Immunities; Immune; Immunities, Humoral; Incidence; Infection; Infectious Human Wart Virus; Infrastructure; Investigators; Knowledge; Lead; Lesion; Male Circumcision; Malignant Penile Neoplasm; Malignant Penile Tumor; Malignant Tumor of the Penis; Malignant neoplasm of penis; Measures; Methods; Molecular Virology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Natural History; Papilloma Virus, Human; Papillomavirus, Human; Participant; Pathologic; Pb element; Penile Cancer; Penile Intraepithelial Neoplasia; Penis Cancer; Population; Publishing; Research; Research Infrastructure; Research Personnel; Research Specimen; Researchers; Risk; Risk Factors; Role; STD; Sex Behavior; Sexual Activity; Sexual Behavior; Sexual Partners; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Specimen; Testing; Time; Transmission; Vaccines; Variant; Variation; Venereal Diseases; Venereal Disorders; Venereal Infections; Viral; Viral Burden; Viral Load; Viral Load result; Warts, Genital; Warts, Venereal; Woman; antibody biosynthesis; antibody-based immunity; clinical practice; condoms; condyloma; design; designing; disease risk; disease/disorder; disorder risk; experience; follow-up; heavy metal Pb; heavy metal lead; herpes simplex ii; human alphaherpesvirus 2; human papilloma virus 16; immunoglobulin biosynthesis; improved; innovate; innovation; innovative; male; men; men's; molecular marker; older men; physical state; prospective; public health relevance; repository; sex activity; sex partner; social role; transmission process; urogenital system (genital part); vaccine development; wart virus",Natural History of HPV Infection in Men: The HIM Study," PROJECT NARRATIVE Little is known about the progression of genital HPV infections to disease in men. Just as these data were critical to the successful development and implementation of HPV vaccines for women, they are also critical to the development of vaccines targeting men. The overall goal of this Natural History of HPV Infection in Men (HIM) Study competitive renewal application is to define the natural history of HPV-related genital disease in men. The central hypothesis is that genital disease incidence in men is significantly associated with age and HPV antibody status, and influenced by HPV type and infection duration. To our knowledge this proposed research is the first to prospectively assess HPV infection progression to genital disease in men. As these lesions may be important reservoirs of infection for transmission, they have significance for the disease status of the male as well as his sexual partner(s). In addition to the significant scientific contribution this study will make, the HIM Study has established a data and biological specimen repository with which to test future and ancillary scientific hypotheses related to HPV infection and disease in men.",98803,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",A1,6,2105062,
7779236,R01,CA,2,,01/01/2010,12/31/2010,PA-07-070,2R01CA102184-05A1,,NCI:336581;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073724262,US,PA,191112434,FOX CHASE CANCER CENTER,"MURPHY, MAUREEN E;",1933733;,2R01CA102184,07/01/2003,12/31/2014,"Address; African American; Afro American; Afroamerican; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogene Protein p53; Antioncogenes; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Arginine; Arginine, L-Isomer; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Black Populations; Black or African American; CAP20 protein; CASP-3; CASP3; CDK-Interacting Protein 1; CDK2-associated protein 20 kDa; CDKN1 protein; CDKN1A; CDKN1A Protein; CIP-1 Protein; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cancer Genes; Cancer Treatment; Cancer-Promoting Gene; Cancers; Caspase 3, Apoptosis-Related Cysteine Protease; Cdk2 inhibitor protein; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cellular Tumor Antigen P53; Cessation of life; Cip1 protein; Code; Coding System; Codon; Codon Nucleotides; Colorectal Cancer; Cyclin-Dependent Kinase Inhibitor 1A; Cysteine Protease CPP32; DNA Damage; DNA Injury; Data; Death; Development; Emerogenes; Forecast of outcome; Frequencies (time pattern); Frequency; Gene Expression; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic Transcription; Genetic defect; Germinoblastoma; Goals; Growth; Human; Human, General; Incidence; Individual; L-Arginine; L-Proline; L-Serine; Life; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MDA 6; MDM 2; MDM2; MDM2 gene; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mitochondria; Molecular; Murine; Mus; Mutate; Mutation; NIH; NOXA; National Institutes of Health; National Institutes of Health (U.S.); Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncoprotein p53; Organism; P21; P53; PARP Cleavage Protease; PMAIP1; PMAIP1 gene; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Pic-1 protein (cyclin); Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Prognosis; Proline; Protein Phosphorylation; Protein TP53; Protein p53; Proteins; Public Health; Publishing; RNA Expression; Reporting; Research; Reticulolymphosarcoma; Role; SCA-1; SREBP Cleavage Activity 1; Sarcoma, Germinoblastic; Serine; Signaling Molecule; Sodium Dextran Sulfate; Survival Analyses; Survival Analysis; Susceptibility; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Time; Tissue Growth; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Transforming Genes; Treatment Efficacy; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Genes; Tumor Suppressor Proteins; Underserved Population; United States National Institutes of Health; Variant; Variation; WAF-1 Protein; WAF1 CIP1; WAF1 protein; Work; Yama; Yama protein; anticancer research; anticancer therapy; base; black American; cancer progression; cancer research; cancer risk; cancer therapy; caspase-3; cdn1 protein; colon carcinogenesis; cultured cell line; cyclin-dependent kinase Inhibitor p21; cysteine protease P32; domain mapping; gene product; genome mutation; in vivo; living system; malignancy; mda-6 protein; mitochondrial; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; oncoprotein p21; oncosuppressor gene; ontogeny; outcome forecast; p21 cell cycle regulator; p21 cyclin kinase inhibitor; p21(cip1); p21(waf1-cip1); p21-WAF1; p53 Antigen; p53 Tumor Suppressor; p53-Binding Protein Gene; polymorphism; pro-caspase-3; procaspase-3; protein p21; public health medicine (field); public health relevance; response; senescence; senescent cell-derived inhibitor protein 1; social role; therapeutic efficacy; therapeutically effective; transcription factor; tumor; tumor progression; tumor suppressor; tumorigenesis; under served population; underserved people",Functional Analysis of p53 Polymorphic Variants," PUBLIC HEALTH STATEMENT Published data from our group and others indicate that there are three coding region variants of the p53 protein in human populations, and further that these three variants all have significant differences in p53 function. Whereas a great deal is known about how p53 functions to suppress cancer, to date very little is known about how these polymorphic variants of p53 influence cancer risk or the efficacy of therapy; the proposed research will directly address this question. Because the two lesser-functioning variants (S47 and P72) are both more common in African Americans, data generated from this study has direct relevance to understanding the differences in cancer risk and prognosis in this population.",102184,TCB,Tumor Cell Biology Study Section,A1,5,336581,
7789967,R01,CA,2,,02/01/2010,01/31/2011,PA-07-070,2R01CA102707-06A1,,NCI:271190;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,PHARMACOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"KORNBLUTH, SALLY A;",1899093;,2R01CA102707,07/01/2003,01/31/2015,"APAF1 Protein; ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Address; Affect; Animals; Apaf-1; Apaf-1 protein; Apaf-1L protein; Apaf-3 protein; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Apoptotic Protease Activating Factor; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; BCR-ABL Kinase; Bcr-Abl tyrosine kinase; Binding; Binding (Molecular Function); Blood (Leukemia); Blood Precursor Cell; Bone Marrow; CASP-3; CASP3; CASP9 Protein; CD135; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cancer of Lung; Cancer of the Ovary; Cancers; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase 9, Apoptosis-Related Cysteine Protease; Cell Death; Cell Death, Programmed; Cell-Death Protease; Cells; Cellular injury; Cysteine Protease CPP32; Cytoplasm; Defect; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; FLK2; FLT3; FLT3 gene; Ferricytochrome c; Ferrocytochrome c; Goals; HEK3; Hematopoietic stem cells; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; ICE-like protease; Imatinib; In Vitro; Isoforms; Kinases; Knowledge; LEUKCL; Leukemias, General; Leukemic Cell; Link; Malignant Melanoma; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Ovary; Malignant neoplasm of lung; Malignant neoplasm of ovary; Mch6 protein; Methods; Mitochondria; Molecular; Molecular Interaction; Normal Cell; PARP Cleavage Protease; PTK; Pathway interactions; Patients; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Progenitor Cells, Hematopoietic; Protein Isoforms; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Pulmonary Cancer; Pulmonary malignant Neoplasm; Radiation; Regulation; Resistance; Reticuloendothelial System, Bone Marrow; SCA-1; SREBP Cleavage Activity 1; STK1; Sampling; Signal Pathway; Site; Stimulus; Therapeutic; Therapeutic Agents; Translating; Translatings; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; Work; Yama; Yama protein; apoptotic protease-activating factor 1; base; caspase; caspase-3; caspase-9; cell damage; cell injury; chemotherapeutic agent; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytochrome c; design; designing; hydroxyaryl protein kinase; improved; language translation; leukemia; lung cancer; malignancy; melanoma; mitochondrial; necrocytosis; neoplasm/cancer; ovarian cancer; pathway; pro-caspase-9; procaspase-9; public health relevance; ray (radiation); resistant; therapeutic target; tyrosyl protein kinase",Inhibition  of Cytochrome c-induced Caspase Activation, This proposal addresses the molecular pathways linking activated tyrosine kinases to the suppression of programmed cell death (apoptosis) in leukemias. Understanding these pathways may have broad implications for the treatment of leukemias and other cancers expressing activated tyrosine kinases. The goal of this work is to fully understand these signaling pathways in order to design better therapeutic agents for the treatment of leukemias.,102707,CAMP,Cancer Molecular Pathobiology Study Section,A1,6,271190,
7887445,R01,CA,2,,03/01/2010,12/31/2010,PA-07-279,2R01CA113941-05,,NCI:534447;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KARP, JOEL S;",7181918;,2R01CA113941,04/01/2005,12/31/2014,"Address; Affect; Algorithms; Area; Arts; Automatic Data Processing; Biological Models; Bromides; Calibration; Cancers; Caring; Cell Communication and Signaling; Cell Signaling; Clinic; Clinical; Computer Data Processing; Computer Programs; Computer software; Data; Development; Disease; Disorder; Electronic Data Processing; Electronics; Evaluation; Funding; Gamma Rays; Goals; Human; Human, General; Image; Image Reconstructions; Intracellular Communication and Signaling; La element; Lanthanum; Lesion; Logic; Lutetium; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Positron Emission Tomography; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Metric; Model System; Modeling; Models, Biologic; PET; PET Scan; PET imaging; PET/CT; PET/CT scan; PETSCAN; PETT; Patients; Performance; Position; Positioning Attribute; Positron; Positron Emission Tomography Scan; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Radiation, Gamma; Radioactive Isotopes; Radioisotopes; Radiology; Radiology Specialty; Radiology, General; Radionuclides; Reading; Reconstructions, Image; Relative; Relative (related person); Research; Resolution; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Software; Speed; Speed (motion); System; System, LOINC Axis 4; Tag; Techniques; Technology; Testing; Time; Tracer; Work; Yttrium; analog; attenuation; automated data processing; base; biological signal transduction; computer program/software; design; designing; detector; digital; disease/disorder; imaging; improved; instrument; malignancy; neoplasm/cancer; next generation; physical model; public health relevance; reconstruction; uptake; whole body imaging; whole body scanning",Time-of-Flight PET for Improved Whole-Body Imaging," Project Narrative The overall goal of our project is to investigate and improve time-of-flight (TOF) PET imaging, and to develop technology for the next generation of TOF PET imaging instruments. Evaluation of the factors that contribute to imaging performance will be defined in terms of their impact on image quality and quantification and their effects on the tasks involved in the study of cancer and other disease using PET. We will use methodologies that are predictive of the human's ability to identify and quantify activity uptake in lesions, thus guiding the utilization of TOF PET for the study of cancer.",113941,BMIT,Biomedical Imaging Technology Study Section,,5,534447,
7784017,R01,DA,2,,02/01/2010,01/31/2011,PA-07-070,2R01DA002110-30,,NIDA:309000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,ANESTHESIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"YAKSH, TONY L;",1892483;,2R01DA002110,07/01/1983,01/31/2015,"3-phosphoinositide-dependent protein kinase; 6-Cyano-7-nitroquinoxaline-2,3-dione; 6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-; AKT; Abbreviations; Acute; After Care; After-Treatment; Aftercare; Agonist; Akt protein; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Arthritis; B blood cells; B-Cells; B-Lymphocytes; BZS; Blood Serum; Blotting, Western; Body Tissues; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CNQX; Calcium Channel; Calcium Channel Antagonist Receptor; Carrageenan; Carrageenin; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Chromosome 10; Chromosomes, Human, Pair 10; Chronic; Common Rat Strains; Contin, MS; Control Animal; Data; Dependence; Dorsal Horn Cells; Dorsal Root Ganglia; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 1.14.13.39; EC 2.7; EDRF Synthase; Endo Brand of Naloxone Hydrochloride; Endothelium-Derived Growth Factor Synthase; Enhancers; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Euler-Gaddum Substance P; Evolution; Exposure to; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Face; Formalin; GSK-3; Ganglia, Spinal; Glutamate Receptor; Glutamates; Glycogen Synthase Kinase 3; Guanylyl Cyclase-Activating Factor Synthase; Hyperalgesia; Hyperalgesic Sensations; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; Inflammation; Infumorph; Infusion; Infusion procedures; Injury; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Ion Channels, Calcium; Isoxazoles; K/BxN model; Kadian; Kinases; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Glutamate; LRR protein; Lamepro Brand of Naloxone Hydrochloride; Link; Long-Term Potentiation; MHAM; MK 801; MK801; MMAC1; MSir; Mammals, Mice; Mammals, Rats; Measures; Mediating; Methods; Mice; Modeling; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NADPH-Diaphorase; NK-1 Receptors; NK1R; NKIR; NMDA; NO Synthase; Naloxone; Narcan; Narcanti; Neurons, Dorsal Horn; Neurons, Posterior Horn; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Nociception; Nuclear; Opiates; Opioid; Oramorph; Oramorph SR; PH Domain; PKB protein; PTEN; PTEN gene; PTEN1; Pain; Painful; Peripheral; Pharmacology; Phosphatase and Tensin Homolog; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphotransferases; Pleckstrin-Homology Domain; Posterior Horn Cells; Process; Propionic Acids; Protein Kinase B; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Proto-Oncogene Proteins c-akt; PtdIns; RAC-PK protein; RAFT-1 gene product; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Rat; Rattus; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, Neurokinin-1; Regulation; Rest; Role; Roxanol; SP(1-11); SP-P Receptors; Saline; Saline Solution; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Spinal; Spinal Anesthesia; Spinal Ganglia; Statex SR; Substance P; Substance P Receptor; TAC1R; TACR1; TACR1 gene; Tachykinin Receptor 1; Tactile; Thermal Hyperalgesias; Time; Tissues; Transphosphorylases; United Drug Brand of Naloxone Hydrochloride; V (voltage); VDCC; Voltage-Dependent Calcium Channels; Western Blotting; Western Blottings; Western Immunoblotting; Withdrawal; Work; allodynia; analgesia; arthritic; biological signal transduction; c-akt protein; dorsal horn; dorsal root ganglion; facial; gene product; gsk-3 Gene Product; human FRAP1 protein; hyperalgia; inhibitor; inhibitor/antagonist; leucine-rich repeat protein; mTOR; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); mouse model; neurokinin 1; nociceptive; pain behavior; presynaptic; protein blotting; protein expression; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; receptor; receptor coupling; related to A and C-protein; social role; spinal block; voltage",The Pharmacology of Spinal Analgesics," Project Narrative Hyperalgesia after injury or inflammation involves spinal signaling links, one of which we hypothesize is the Akt cascade. Akt may also mediate opioid tolerance. Our work thus targets this link for these two critical issues in pain.",2110,SCS,Somatosensory and Chemosensory Systems Study Section,,30,309000,
7785764,R01,DA,2,,04/01/2010,03/31/2011,PA-07-070,2R01DA004398-23A1,,NIDA:379800;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"KOOB, GEORGE F;",1881505;,2R01DA004398,04/25/1987,03/31/2015,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ACTH-Releasing Factor; Acute; Addiction, Cocaine; Addiction, Drug; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Affect; Agonist; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Bed Nucleus of Stria Terminalis; Brain; Brain region; CRF-41; CRH; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chemical Dependence; Chronic; Cocaine; Cocaine Dependences; Common Rat Strains; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Cyclic AMP-Dependent Protein Kinases; Data; Dependence; Dependence, Drug; Dependence, Substance; Dependences, Cocaine; Development; Disease; Disorder; Dopamine; Dopamine Antagonists; Dopamine Receptor Antagonists; Dopaminergic Antagonists; Dose; Drug Addiction; Drug Dependency; Drug usage; Drugs; Dynorphins; Electrodes, Implanted; Elements; Encephalon; Encephalons; Funding; G Protein Go; G(o) Protein; G-Protein, Go Subunit; G-Protein, Inhibitory Go; G-Proteins; GTP Binding Protein alpha Subunit, Go; GTP-Binding Proteins; GTP-Regulatory Proteins; Go Alpha Subunit; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanine Nucleotide-Binding Protein Go; Human; Human, General; Hydroxytyramine; Hypothalamic structure; Hypothalamus; Implanted Electrodes; Impulsivity; Incentives; Intake; Intoxication; Intracellular Communication and Signaling; Knowledge; Laboratories; Lateral; Lead; Levarterenol; Levonorepinephrine; Link; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medial; Medial Forebrain Bundle; Median Forebrain Bundle; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Modeling; Molecular Target; Motivation; Negative Reinforcements; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Neurotransmitters; Noradrenaline; Norepinephrine; Nucleus; Nucleus Accumbens; Opiate Peptides; Opioid Peptide; PKA; Pathology; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Prefrontal Cortex; Process; Protein Kinase A; Rat; Rattus; Reinforcements, Negative; Relapse; Rewards; Role; SCHED; Schedule; Science of neurochemistry; Self Administration; Self Stimulation; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Stress; Stria Terminalis Nucleus; Striatum, Ventral; Structure; Structure of median forebrain bundle; Structure of terminal stria nuclei of preoptic region; Substance Addiction; System; System, LOINC Axis 4; Testing; Time; Ventral Striatum; Withdrawal; Work; addiction; amygdaloid nuclear complex; basal forebrain; base; biological signal transduction; cAMP-Dependent Protein Kinases; corticotropin releasing hormone; cost; craving; disease/disorder; dopamine system; drug abstinence; drug use; drug/agent; heavy metal Pb; heavy metal lead; hedonic; hypothalamic; incentive; inducement; insight; median forebrain bundle; mesolimbic system; model organism; neurobiological; neurochemistry; neuronal; novel; protein function; psychostimulant; public health relevance; social role; stressor; working memory",Neuronal Substrates of Cocaine Reward," PROJECT NARRATIVE Cocaine addiction is considered a chronic relapsing disorder with compulsive use that that interacts with stress to cause serious pathology and cost to society. Knowledge of the neurochemical/neurocircuitry changes of the brain motivational and stress systems that provide the motivational basis for vulnerability for increased drug intake with extended access are beginning to provide insights into the neurobiological changes that may lead to vulnerability to the compulsivity and relapse associated with addiction. The present proposal has developed an animal model and brain neurotransmitter and molecular targets in the brain stress and motivational neuronal circuits that will provide insights not only into the role of stress in the compulsivity that is associated with cocaine dependence, but may also provide key markers for the development of dependence and ultimately key targets for understanding vulnerability and developing novel treatments.",4398,NMB,Neurobiology of Motivated Behavior Study Section,A1,23,379800,
7729704,R01,DA,2,,02/01/2010,01/31/2011,PA-07-226,2R01DA008213-15,,NIDA:331000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PHARMACOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RUDNICK, GARY W;",1971637;,2R01DA008213,05/01/1993,01/31/2015,"1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-; 3,4 methylenedioxymethamphetamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; 5HT transporter; 5HTT protein; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ATP-protein phosphotransferase; Active Sites; Address; Affect; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Asperger Syndrome; Asperger's Disorder; Back; Behavior; Behavioral; Binding; Binding (Molecular Function); Brain; Cell Communication and Signaling; Cell Signaling; Cells; Cocaine; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Defect; Dependence; Dephosphorylation; Dorsum; Drugs; Ecstasy; Ecstasy - drug; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enteramine; Enzymes; Event; Family; Genetic Alteration; Genetic Change; Genetic defect; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Hippophaine; Human; Human, General; Intracellular Communication and Signaling; Lead; Location; MDMA; Man (Taxonomy); Man, Modern; Medication; Mental disorders; Mental health disorders; Methylenedioxymethamphetamine; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mononitrogen Monoxide; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nature; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; PDE; PKG; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatases; Phosphates; Phosphodiesterases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Physiology; Position; Positioning Attribute; Process; Production; Protein Dephosphorylation; Protein Kinase; Protein Kinase G; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Psychiatric Disease; Psychiatric Disorder; Regulation; Regulatory Protein; Serotonin; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Sites, Active; Structure; Substance abuse problem; Synapses; Synaptic; Synaptic Vesicles; Testing; Therapeutic; Unspecified Mental Disorder; Work; abuse of substances; abused drugs; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; conformation; conformational state; drug of abuse; drug/agent; drugs abused; drugs of abuse; ecstasy; endothelial cell derived relaxing factor; gene product; genetic regulatory protein; genome mutation; glycogen synthase a kinase; guanosine 3'5' monophosphate; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; inhibitor; inhibitor/antagonist; inorganic phosphate; mental illness; mutant; neuronal; neurotransmitter release; neurotransmitter transport; pathway; phosphoric diester hydrolase; phosphorylase b kinase kinase; protein complex; psychological disorder; public health relevance; regulatory gene product; response; reuptake; serotonin transporter; small molecule; sodium-dependent serotonin transporter; substance abuse",Neurotransmitter Transport," This proposal concerns a mechanism for regulation of serotonin transporter, a target for drugs of abuse and antidepressants. Defects in regulation were found in a mutant form of this transporter associated with psychiatric disorders. We aim to understand the structural and mechanistic events that are responsible for this regulation at a molecular level.",8213,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,15,331000,
7784069,R01,DA,2,,01/15/2010,12/31/2010,PA-08-263,2R01DA013093-11,,NIDA:567304;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,FORT WORTH,UNITED STATES,NONE,12,043807882,US,TX,76129,TEXAS CHRISTIAN UNIVERSITY,"FLYNN, PATRICK M;",2430358;,2R01DA013093,09/30/1999,12/31/2014,"21+ years old; AOD use; Address; Adolescent; Adolescent Youth; Adopted; Adoption; Adult; African American; Afro American; Afroamerican; Alcohol or Other Drugs use; Americas; Attention; Attitude; Awareness of self; Black Populations; Black or African American; Client; Cognitive; Collaborations; Communication; Communities; Curriculum; Drops; Drug abuse; Education for Intervention; Educational Curriculum; Educational Intervention; Educational workshop; Effectiveness; Elements; Equilibrium; Evaluation; Evidence based program; Evidence based treatment; Experimental Designs; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Health Care Providers; Health Knowledge, Attitudes, Practice; Health Personnel; Healthcare Providers; Healthcare worker; Hispanic Populations; Hispanics; Hispanics or Latinos; Human, Adult; Illinois; Institution; Instruction Intervention; Intervention; Intervention Strategies; Justice; Knowledge, Attitudes, Behaviors; Knowledge, Attitudes, Practice; Latino Population; Left; Life; Maps; MeSH Descriptors Class 4; Measures; Mediating; Motivation; NIDA; NIH; National Institute of Drug Abuse; National Institutes of Health; National Institutes of Health (U.S.); New Jersey; New York; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PROV; Participant; Personal awareness; Phase; Population; Preparedness; Process; Programs (PT); Programs [Publication Type]; Provider; Public Health; Readiness; Recruitment Activity; Registries; Research; Research Resources; Resources; Rural; Sampling; Self Perception; Self image; Self view; Services; Spanish Origin; Structure; Substance abuse problem; Surgical; Surgical Interventions; Surgical Procedure; Technology Transfer; Testing; Texas; Therapeutic; Therapeutic Community; Therapeutic community technique; Training; Training Intervention; Treatment Effectiveness; Treatment Period; United States National Institutes of Health; Visuospatial; Workshop; Youth; Youth 10-21; abuse of drugs; abuse of substances; abuses drugs; addiction; adolescent substance abuse; adult human (21+); adult youth; balance; balance function; base; black American; clinical practice; community based treatment; coping; design; designing; geographic site; health care personnel; health care worker; health provider; healthcare personnel; high risk; hispanic community; implementation science; improved; innovate; innovation; innovative; instructional intervention; intervention program; interventional strategy; juvenile; juvenile human; medical personnel; meetings; phase 1 study; programs; public health medicine (field); public health relevance; recruit; satisfaction; self awareness; self knowledge; skills; substance abuse; substance use; success; surgery; tool; treatment center; treatment days; treatment duration; treatment program; treatment provider; urban American Indian; urban native american; visual spatial; young adult; youth substance abuse",Extending Drug Abuse Treatment & Assessment Resources (DATAR5)," Project Narrative Because substance use is a significant problem among youth in the U.S., and treatment providers are faced with high drop-out rates, the proposed research has the potential to impact clinical practice by increasing treatment motivation, engagement, and retention, and improving outcomes. Indeed, the adolescent population is important to the NIH and NIDA, and improving the quality of substance abuse treatment service delivery through the use of research-tested interventions will benefit public health. This application proposes to adapt treatment induction and retention tools, determine their effectiveness, and examine the process of their transfer and implementation in substance abuse treatment programs from 6 geographic regions across the U.S.",13093,NIDA,Neuropharmacology Research Subcommittee,,11,567304,
7778991,R01,DA,2,,01/15/2010,12/31/2010,PA-07-409,2R01DA014317-08A1,,NIDA:592564;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN FRANCISCO,UNITED STATES,,08,044875854,US,CA,94107,SCIENTIFIC ANALYSIS CORPORATION,"HUNT, GEOFFREY P;",1888350;,2R01DA014317,09/01/2001,12/31/2013,"1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 3,4 methylenedioxymethamphetamine; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adopted; Advertising; Age; American; Amphetamines; Area; Asian Americans; Asians; Behavior; Belief; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bisexual; Cocaine; Code; Coding System; Communities; Consumption; Crystal Meth; Dancing; Dancings; Data; Deoxyephedrine; Desoxyephedrine; Drug abuse; Drug usage; Drugs; Drugs, Illicit; Ecstasy; Ecstasy - drug; Employee Strikes; Ethnic Origin; Ethnicity; Ethnicity aspects; Ethnography; Event; Exposure to; Gays; HIV; HTLV-III; Heterosexuals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Illicit Drugs; Individual; Inhalant dose form; Interview; Investigators; Ketamine; LAV-HTLV-III; Lead; Literature; Lymphadenopathy-Associated Virus; MDMA; Maps; Marketing; Medication; Methamphetamine; Methods; Methylamphetamine; Methylenedioxymethamphetamine; Motivation; N-Methyl-3,4-methylenedioxyamphetamine; N-Methylamphetamine; Nitrites; Orientation, Sexual; Participant; Pattern; Pb element; Perception; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Preventive Intervention; Process; Publishing; Qualitative Methods; Qualitative Research; Questionnaires; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Respondent; Risk; Risk Behaviors; Risky Behavior; Ritual compulsion; Rituals; Rohypnol; SCHED; STD; SUBGP; Sampling; San Francisco; Schedule; Scientist; Sex Orientation; Sexuality; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Site; Social Environment; Social Network; Strikes; Strikes, Employee; Structure; Subgroup; Survey Instrument; Surveys; Time; Variant; Variation; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Work; Youth; Youth 10-21; abuse of drugs; abuses drugs; at risk behavior; base; club drug; community organizations; drug use; drug/agent; ecstasy; ethnographic; flexibility; heavy metal Pb; heavy metal lead; informant; inhalant; intervention program; life history; men; men who have sex with men; men who have sex with other men; men's; oriental; parent project; peer; preventional intervention strategy; public health relevance; sex risk; social; social climate; social context; socioenvironment","Asian American MSM, Club Drugs and Nightlife"," 7. Project Narrative  This qualitative research project will provide much-needed empirical information about the extent and social context of club drug use by young Asian American men who have sex with men (MSM). Findings from this project will provide information regarding the relationships between their drug use, their identities as young Asian American men, and their sexual identities, sexual practices, and risks of exposure to HIV. This study's findings will be published in forms appropriate for the following audiences: people who work in drug abuse and HIV treatment, prevention and intervention programs; social scientists; and clinicians and other representatives from the broader biomedical community.",14317,CIHB,Community Influences on Health Behavior,A1,8,592564,
7792877,R01,DA,2,,01/15/2010,12/31/2010,PA-08-217,2R01DA015403-06A1,,NIDA:345700;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BELMONT,UNITED STATES,,07,046514535,US,MA,02478,"MC LEAN HOSPITAL (BELMONT, MA)","ANDERSEN, SUSAN L;",1964852;,2R01DA015403,07/01/2002,12/31/2014,"12-20 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-Hydroxydopamine; 6-OHDA; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AD/HD; ADHD; AOD use; Addiction, Drug; Address; Adolescence; Adolescent; Adolescent Youth; Agonist; Alcohol or Other Drugs use; Amphetamines; Animals; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Autoreceptors; Behavior; Behavioral; Chemical Dependence; Cocaine; Common Rat Strains; Confocal Microscopy; D1 receptor; Data; Dependence, Drug; Dopamine; Dopamine D1 Receptor; Dopamine Receptor; Drug Addiction; Drug Dependency; Drug Exposure; Drug abuse; Drugs; Environment; Exposure to; Female; Gender; Glutamates; Goals; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Impulsivity; Intervention; Intervention Strategies; Intervention Studies; L-Glutamate; Laboratories; Male Adolescents; Mammals, Rats; Measures; Medication; Messenger RNA; Methylphenidate; Microdialysis; Microscopy, Confocal; Neurochemistry; Oxidopamine; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Play; Population; Prefrontal Cortex; Preventive Intervention; Production; RNA, Messenger; Rat; Rattus; Receptor Protein; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Role; Science of neurochemistry; Staging; Substance Use Disorder; Substance abuse problem; Symptoms; Testing; Time; Work; abuse of drugs; abuse of substances; abuses drugs; addiction; adolescence (12-20); adolescent boy; at risk behavior; attention deficit hyperactive disorder; behavior test; behavioral test; craving; dopamine D3 receptor; dopamine system; drug abuse prevention; drug addiction prevention; drug reward; drug seeking behavior; drug use prevention; drug/agent; experiment; experimental research; experimental study; extracellular; high risk; immunoreactivity; interventional strategy; juvenile; juvenile human; mRNA; male; neurobiological mechanism; neurochemistry; novel; preference; prevent; preventing; preventional intervention strategy; public health relevance; receptor; receptor expression; research study; response; sex; social role; substance abuse; substance use; teenage",Early Drug Exposure and Drug Reward Mechanisms," We propose to study neurobiological mechanisms that underlie currently recognized commonalities in behavioral manifestations of attention deficit hyperactivity disorder (ADHD) and drug addiction. We will use behavioral, neurochemical, and neuroanatomical approaches to investigate prefrontal dopamine function and the emergence of substance abuse-related problems with the goal of developing new, preventative strategies that may be used to reduce drug abuse in this high-risk population.",15403,ZRG1,Special Emphasis Panel,A1,6,345700,
7786352,R01,DA,2,,02/01/2010,01/31/2011,PA-07-070,2R01DA016310-06A1,,NIDA:690059;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CLAREMONT,UNITED STATES,NONE,26,076183789,US,CA,91711,CLAREMONT GRADUATE UNIVERSITY,"BAEZCONDE-GARBANATI, LOURDES ALBERTINA;UNGER, JENNIFER BETH (contact);",1914388;1943039 (contact);,2R01DA016310,04/01/2003,11/30/2014,"0-11 years old; 12-20 years old; 18 year old; 21+ years old; AOD use; Acculturation; Acculturations; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Alcohol or Other Drugs use; Alcohols; Antiheparin Factor; Area; Assimilation; Assimilations; Behavior; Blood Platelet Factor IV; Blood platelet factor 4; Chemical Class, Alcohol; Chemokine (C-X-C motif) Ligand 4; Chicanas; Chicanos; Child; Child Youth; Children (0-21); Cognitive Discrimination; Communication; Conflict; Conflict (Psychology); Cultural Assimilation; Data; Data Set; Dataset; Demographic Factors; Dependency; Dependency (Psychology); Deterioration; Development; Discrimination; Discrimination (Psychology); Drug abuse; Drug usage; Drugs; Education; Educational Mainstreaming; Educational aspects; Emotional; Employment; Epidemiology; Extended Family; Factor 4; Factors, Psychological; Family; Family member; Family, Extended; Feeling; Friends; Friendships; Future; Gender; Generalized Growth; Generations; Goals; Growth; Health Instruction; Health Training; Health Tutoring; Health behavior; Health education; Heparin Neutralizing Protein; Hispanic Americans; Hispanic Populations; Hispanics; Hispanics or Latinos; Home; Home environment; Human, Adult; Human, Child; Immigrant; Individual; Intervention; Intervention Strategies; Investigators; Latino Population; Lead; Learning; Life; Longitudinal Studies; Los Angeles; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Marihuana; Marriage; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mexican Americans; Occupational; Outcome; Parent-Child Relations; Parent-Child Relationship; Parents; Participant; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Platelet Factor 4; Population; Problem behavior; Psychological Factors; Psychosocial Factor; Public Health; Recombinant Platelet Factor 4; Recommendation; Research; Research Personnel; Research Resources; Researchers; Residential Mobility; Resources; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Role; Schools; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Societies; Socio-economic status; Socioeconomic Status; Spanish Americans; Spanish Origin; Staging; Status, Socioeconomic; Stress; Students; Survey Instrument; Surveys; Tissue Growth; Tobacco Consumption; Tobacco use; Training; Violence; abuse of drugs; abuses drugs; adolescence (12-20); adult human (21+); adult youth; at risk behavior; behavioral problem; behavioral/social science; career; children; cohesion; cohort; college; cultural values; drug use; drug/agent; eighteen year old; emerging adult; emerging adulthood; emotional dependency; ethnic discrimination; experience; family structure; feelings; gamma-Thromboglobulin; health disparities; health disparity; heavy metal Pb; heavy metal lead; high risk; high school; hispanic community; improved; interventional strategy; juvenile; juvenile human; long-term study; ontogeny; parent child interaction; parent monitoring; parent offspring interaction; parental monitoring; pathway; peer; platelet factor IV; prevent; preventing; psychosocial variables; public health medicine (field); public health relevance; role model; social; social role; social science research; substance use; teenage; violent; violent behavior; young adult; youngster",Drug Use Among Hispanic Emerging Adults, This application addresses the public health goals of preventing and reducing substance use among young adults. It also aims to reduce health disparities by identifying risk and protective factors that are specific to Hispanics.,16310,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",A1,6,690059,
7782854,R01,DA,2,,01/15/2010,11/30/2010,PA-07-070,2R01DA017240-05A2,,NIDA:222750;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN ANTONIO,UNITED STATES,PHARMACOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"GERAK, LISA R;",1971742;,2R01DA017240,12/01/2003,11/30/2014,"2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-; 3 alpha, 5 beta-Tetrahydroprogesterone; 3 alpha-Hydroxy-5 beta-pregnan-20-one; 3-Hydroxypregnan-20-one; 5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-; Absolute ethanol; Acute; Alcohol withdrawal syndrome; Alcohol, Ethyl; Anxiety; Behavioral; Benzodiazepine Compounds; Benzodiazepines; Chronic; Clinical; Common Rat Strains; Dependence; Development; Disease; Disorder; Dose; Drug Interactions; Drug usage; Drugs; ETOH; Effectiveness; Eltanolone; Ethanol; Flunitrazepam; Fluridrazepam; Food; Grain Alcohol; Grant; Insomnia; Insomnia Disorder; Lab Findings; Laboratories; Laboratory Finding; Leptazole; Mammals, Rats; Measures; Medication; Methylcarbinol; Pentamethylenetetrazole; Pentetrazole; Pentylenetetrazol; Pentylenetetrazole; Pharmaceutic Preparations; Pharmaceutical Preparations; Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-; Pregnan-3alpha-ol-20-one; Pregnanolone; Pregnanolone, (3alpha,5beta)-isomer; Procedures; Rat; Rattus; Receptor Protein; Seizures; Site; Sleeplessness; Stimulus; System; System, LOINC Axis 4; Testing; Training; Treatment Period; Withdrawal; alcohol pharmacology; alcohol withdrawal; disease/disorder; drug discrimination; drug use; drug/agent; ethanol pharmacology; ethanol withdrawal; improved; insight; neurosteroids; prevent; preventing; public health relevance; receptor; receptor function; treatment days; treatment duration; withdrawal from alcohol",Behavioral Effects of Neuroactive Steroids, Project Narrative Benzodiazepine dependence limits the clinical use of these drugs. This grant evaluates differences in the chronic effects of benzodiazepines and neuroactive steroids and investigates the possibility of using neuroactive steroids to reduce the development or expression of benzodiazepine tolerance and dependence.,17240,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",A2,5,222750,
7779742,R01,DC,2,,03/01/2010,02/28/2011,PA-07-070,2R01DC001368-19,,NIDCD:323000;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,SAINT LOUIS,UNITED STATES,OTOLARYNGOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SALT, ALEC N;",1905813;,2R01DC001368,01/01/1992,02/28/2015,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Abbreviations; Action Potentials; Adexone; Affect; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anatomic; Anatomical Sciences; Anatomy; Anemul mono; Animals; Anions; Antimicotico; Aquapred; Area; Automobile Driving; Auxiloson; Azona; Baycuten; Baycuten N; Blood; Body Tissues; CAPS; Capsules; Cations; Cavia; Cell Membrane Permeability; Cerebrospinal Fluid; Characteristics; Charge; Cochlea; Cochlear Organ; Cochlear structure; Complex; Computer Simulation; Computerized Models; Concentration measurement; Corson; Cortidexason; Cortisumman; Data; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Diffusion; Dinormon; Disease; Disorder; Drivings, Automobile; Drug Delivery; Drug Delivery Systems; Drug Kinetics; Drug Targeting; Drug Targetings; Drug usage; Drugs; Ear; Ear structure; Ear, Internal; Endolymph; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Foundations; Frequencies (time pattern); Frequency; Gammacorten; Garamicin; Garamycin; Gel; Genoptic; Genoptic S.O.P.; Gentamicins; Glycolates; Goals; Guinea Pigs; Hexadecadrol; Hexadrol; Human; Human, General; Injection of therapeutic agent; Injections; Ion-Selective Electrodes; Ion-Sensitive Electrodes; Ions; Knowledge; Labyrinth; Lateral; Liquid substance; Location; Lokalison-F; Loverine; Mammals, Guinea Pigs; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Medication; Membrane; Methods; Methods and Techniques; Methods, Other; Methylfluorprednisolone; Mice; Millicorten; Modeling; Models, Computer; Monitor; Murine; Mus; Mymethasone; Ocasa; Orgadrone; Organism-Level Process; Organismal Process; Patients; Pattern; Perilymph; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Protocols, Treatment; RGM; Regimen; Research; Reticuloendothelial System, Blood; Role; Round Window; Sampling; Scala Tympani; Science of Anatomy; Simulation, Computer based; Site; Spersadex; Spersadox; Structure; Structure of cochlear window; System; System, LOINC Axis 4; Techniques; Time; Tissues; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tympanus, Scala; U-Gencin; Visumetazone; Work; anatomy; auricularum; base; capsule (pharmacologic); clinical practice; clinical relevance; clinically relevant; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; disease/disorder; dosage; driving; drug distribution; drug use; drug/agent; experiment; experimental research; experimental study; fenestra cochleae; fluid; human data; in silico; in vivo; inner ear; liquid; local drug delivery; mathematical model; mathematical modeling; membrane permeability; membrane structure; middle ear; nano particle; nanoparticle; novel; poly(lactic acid); polylactic acid; programs; public health relevance; research study; salicylate; seal; simulation; social role; solute; spinal fluid; virtual simulation; web page",INNER EAR FLUID INTERACTIONS," Project Narrative In many cases, ears affected by diseases would benefit from treatments using locally applied drugs. At present, drug delivery protocols are developed by trial and error in humans, sometimes to the detriment of the patient. This project seeks to develop an understanding of pharmacokinetics in the ear that will, in conjunction with computer models, allow drug treatment protocols to be scientifically based.",1368,AUD,Auditory System Study Section,,19,323000,
7773901,R01,EB,2,,02/01/2010,11/30/2010,PA-07-070,2R01EB004759-05,,NIBIB:361057;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,WORCESTER,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,03,041508581,US,MA,01609,WORCESTER POLYTECHNIC INSTITUTE,"TANG, DALIN  (contact);ZHENG, JIE ;",7352052;8056702 (contact);,2R01EB004759,09/01/2004,11/30/2013,"3D modeling; Acute; American Heart Association; Analysis, Data; Angiogram; Angiography; Apoplexy; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Automation; Benchmarking; Best Practice Analysis; Blood flow; Body Tissues; Cadaver; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Classification; Classification Scheme; Complement; Complement Proteins; Computer Programs; Computer Simulation; Computer software; Computerized Models; Coronary; Data; Data Analyses; Diagnosis; Diagnosis, Ultrasound; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Echography; Echotomography; Event; Future; Goals; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Histology; Human; Human, General; Hydrogels; Image; Image Analyses; Image Analysis; Imaging technology; In Vitro; Intracellular Communication and Signaling; Lead; Lesion; Liquid substance; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Mechanics; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Medicare; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Monitor; Morphology; Myocardial Infarct; Myocardial Infarction; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Organ System, Cardiovascular; Patients; Pb element; Physicians; Pressure; Pressure- physical agent; Prevention; Procedures; Property; Property, LOINC Axis 2; Public Health; ROC Analysis; Research; Risk; Risk Factors; Rupture; Sampling; Scheme; Screening procedure; Segmentation, imaging; Series; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Software; Streaks, Arterial Fatty; Stress; Stretching; Stroke; Structure; Syndrome; Systematics; Techniques; Testing; Tissues; Title 18; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Validation; Vascular Accident, Brain; Vascular, Heart; Zeugmatography; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; base; biological signal transduction; brain attack; cardiac infarct; cardiovascular disorder; cerebral vascular accident; circulatory system; clinical applicability; clinical application; commercialization; computational modeling; computational models; computational simulation; computer based models; computer program/software; computerized modeling; computerized simulation; coronary attack; coronary infarct; coronary infarction; cost; diagnostic ultrasound; fluid; health insurance for disabled; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; image evaluation; imaging; imaging Segmentation; improved; in silico; in vivo; indexing; liquid; pressure; public health medicine (field); public health relevance; screening; screenings; shear stress; simulation; sonogram; sonography; sound measurement; stroke; success; three-dimensional modeling; tool; ultrasound; ultrasound imaging; ultrasound scanning; validation studies; virtual simulation; vulnerable plaque",In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment, Project Narrative: Many cardiovascular events (such as heart attack and stroke) are caused by atherosclerotic plaque rupture which may happen without any warning signals. Success of this project will lead to more accurate in vivo coronary plaque vulnerability assessment and predictions for possible plaque rupture risk so that better and timely decisions for treatment can be made leading to better public health and reduced costs of Medicare. Commercialization of the research results is possible with the automation of model construction and data analysis procedures.,4759,BMIT,Biomedical Imaging Technology Study Section,,5,361057,
7780119,R01,ES,2,,01/07/2010,11/30/2010,PA-07-070,2R01ES004106-24,,NIEHS:324382;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,PULLMAN,UNITED STATES,BIOLOGY,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"SMERDON, MICHAEL J;",1902617;,2R01ES004106,07/01/1986,11/30/2014,"2,4(1H,3H)-pyrimidinedione; 2,4-dioxopyrimidine; 2,4-pyrimidinediol; 2-hydroxy-4-(3H)-pyrimidione; 4-hydroxy-2-(1H)-pyrimidione; Abscission; Actinic Rays; Activation, Gene; Automobile Driving; Base Excision Repairs; Binding Sites; Bittner Virus; Cancer Cause; Cancer Etiology; Cancers; Carcinogens, Environmental; Cell Extracts; Cell Transformation, Neoplastic; Cells; Chemicals; Chromatin; Chromatin Structure; Combining Site; Complex; DNA; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA Packaging; DNA Polymerase I; DNA Polymerase II; DNA Polymerase alpha; DNA Polymerase epsilon; DNA Repair; DNA lesion; DNA repair protein; DNA-Dependent DNA Polymerase I; DNA-Dependent DNA Polymerase II; Defense Mechanisms; Deoxyribonucleic Acid; Drivings, Automobile; Elements; Energy Transfer; Environmental Carcinogens; Enzymes; Equilibrium; Excision; Excision Repair; Extirpation; Flanking Repeat Sequences; Gene Activation; Gene Transcription; Genes; Genes, Viral; Genes, rRNA; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Glucocorticoids; Goals; Histones; Hormone Receptor; Hormone Responsive; Human; Human, General; Klenow Fragment; Laboratories; Lesion; Life; Location; Long Terminal Repeats; MMTV; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Mammary Cancer Virus; Mammary Tumor Virus, Mouse; Man (Taxonomy); Man, Modern; Mice; Molecular; Molecular Biology, Recombinant DNA; Monitor; Mouse Mammary Tumor Virus; Murine; Mus; Mutation; Neoplastic Cell Transformation; Nucleosomes; Nucleotide Excision Repair; Phenotype; Pol I; Pol II; Position; Positioning Attribute; Prevention; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Purines; RNA Expression; Reactive Site; Recombinant DNA; Removal; Repair, Excision; Repairs, Base Excision; Research; Ribosomal RNA Genes; Role; S cerevisiae; Saccharomyces cerevisiae; Site; Sun/Ultra-Violet Rays; Surface; Surgical Removal; Terminal Repeat; Terminal Repeat Sequences; Terminal Repeats, Long; Therapeutic Glucocorticoid; Transcription; Transcription, Genetic; UV damage; UV radiation; Ultraviolet Rays; Unscheduled DNA Synthesis; Uracil; Viral Genes; Yeast, Baker's; Yeast, Brewer's; Yeasts; balance; balance function; base; chromatin remodeling; coping; driving; environmental agent; gene product; genome mutation; histone modification; in vivo; insight; long terminal repeat, nucleic acid; malignancy; mammary tumor virus; milk agent; mutant; neoplasm/cancer; neoplastic; neoplastic transformation; prototype; psychological defense mechanism; public health relevance; purine; rDNA; rRNA Genes; receptor binding; repair; repaired; resection; restriction enzyme; social role; ultra violet damage; ultraviolet damage; ultraviolet light; ultraviolet radiation",DNA Repair In A Hormone Responsive Gene," DNA damage is detrimental to all living cells and repair of these lesions in mammalian cells is a 'frontline defense' against mutations and cancer. We use prototype DNA-damaging agents to elicit DNA repair in different regions of DNA packaging in cells to determine how cells cope with repair of 'buried' lesions in DNA. Thus, results from our laboratory have implications for the broad spectrum of cancer etiology, prevention and treatment.",4106,CE,Cancer Etiology Study Section,,24,324382,
7785938,R01,ES,2,,02/01/2010,11/30/2010,PA-07-070,2R01ES006272-14,,NIEHS:378916;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,WOODS HOLE,UNITED STATES,,10,001766682,US,MA,02543,WOODS HOLE OCEANOGRAPHIC INSTITUTION,"HAHN, MARK E;",1938780;,2R01ES006272,12/10/1992,11/30/2014,"2,3,7,8-Tetrachlorodibenzo-p-dioxin; 3,4-Benzopyrene; 3,4-Benzpyrene; AHR; ARNT; ARNT gene; ATF; Adverse effects; Anti-Oncogenes; Antioncogenes; Aromatic Hydrocarbons; Aromatic Polycyclic Hydrocarbons; Aryl Hydrocarbon Receptor; Assay; Benzo(a)pyrene; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Blood Vessels; Brachydanio rerio; CHIP assay; Cell Culture Techniques; Cells; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Characteristics; Chemical Exposure; Co-Immunoprecipitations; Complex; Danio rerio; Data; Development; Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-; Dioxin Compound; Dioxin Receptor, Nuclear Translocator Gene; Dioxins; Disease; Disorder; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Emerogenes; Endometriosis; Endometriosis, site unspecified; Environmental Pollution; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Exons; Exposure to; Family; Fishes; Gene Expression; Gene Targeting; Gene Transcription; General Transcription Factor Gene; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Polymorphism; Genetic Transcription; Germ Lines; HIF-1 Beta Gene; HIF-1Beta Gene; HIF-1beta; HIF1-Beta Gene; HIF1B; HIF1B Gene; HIF1Beta; HIF1beta Gene; HTH DNA Binding Domain; HTH Motifs; Health; Helix-Turn-Helix Motifs; Human; Human Cell Line; Human, General; Hydrocarbons, Aromatic; Hypoxia; Hypoxia Inducible Factor; Hypoxia-Inducible Factor 1 Beta Gene; Hypoxia-Inducible Factor 1, Beta Subunit Gene; Hypoxic; Immune Function, Cellular; Infertility, Male; Ligands; Link; Male Infertility; Man (Taxonomy); Man, Modern; Measures; Mediating; Model System; Modeling; Models, Biologic; Molecular Interaction; Names; Nuclear Receptors; Nuclear Translocator; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oxygen Deficiency; PAH; Pathway interactions; Phenotype; Physiologic; Physiological; Play; Polycyclic Hydrocarbons, Aromatic; Polymorphism (Genetics); Polymorphism, Genetic; Polynuclear Aromatic Hydrocarbons; Proteins; Proto-Oncogene, Transcription Factor; RNA Expression; RNA, Small Interfering; Receptor Signaling; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Regulation; Repression; Research; Response Elements; Role; Signal Pathway; Small Interfering RNA; Specificity; Stress; TCDD; TCDD Receptors; Targetings, Gene; Testing; Tet; Tetanus Helper Peptide; Tetrachlorodibenzodioxin; Toxic effect; Toxicities; Transcription; Transcription Activation; Transcription Corepressor; Transcription Regulatory Protein; Transcription Repressor; Transcription Repressor/Corepressor; Transcription factor genes; Transcription, Genetic; Transcriptional Activation; Transcriptional Corepressor; Transcriptional Regulatory Protein; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Treatment Side Effects; Tumor Cell; Tumor Suppressing Genes; Tumor Suppressor Genes; Up-Regulation; Variant; Variation; Vertebrate Animals; Vertebrates; Woman; Zebra Danio; Zebra Fish; Zebrafish; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; activating transcription factor; ahr ligand; aryl hydrocarbon receptor ligand; cell growth; chromatin immunoprecipitation; dioxin receptor, nuclear translocator; disease/disorder; endometriosis; environmental contaminant; environmental contamination; environmental stressor; experiment; experimental research; experimental study; gain of function; gene product; helix loop helix; helix turn helix; human disease; immune function; in vivo; inhibitor; inhibitor/antagonist; insight; loss of function; member; mutant; neoplastic cell; nuclease; oncosuppressor gene; overexpression; paralog; paralogous gene; pathway; polymorphism; polynuclear aromatic hydrocarbon; prevent; preventing; public health relevance; reproductive; research study; response; siRNA; side effect; sim gene product; sim protein; single-minded gene product; single-minded protein; social role; therapy adverse effect; toxicant; transcription factor; treatment adverse effect; vascular; vertebrata",AHR Signaling in Mammalian and Non-Mammalian Models," Public Health Relevance (Project Narrative) The aryl hydrocarbon receptor repressor (AHRR), a protein found in humans and other vertebrate animals, functions to regulate the ability of toxicants such as dioxin and carcinogenic polycyclic aromatic hydrocarbons to cause altered gene expression and toxicity. AHRR polymorphisms have been linked to male infertility and endometriosis in women, and the AHRR has been proposed to function as a tumor suppressor gene. The proposed research will elucidate the mechanisms by which human AHRR and its polymorphic variants regulate the activity of signaling pathways involved in the response to hypoxia and toxicants such as dioxin, providing new insight into its role in human disease.",6272,ZRG1,Special Emphasis Panel,,14,378916,
7782171,R01,EY,2,,02/01/2010,01/31/2011,PA-07-070,2R01EY008128-20A1,,NEI:375000;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,OPHTHALMOLOGY,18,036837920,US,TX,772045037,UNIVERSITY OF HOUSTON,"CHINO, YUZO M;",1902552;,2R01EY008128,02/01/2010,01/31/2015,"21+ years old; Adult; Affect; Age; Amblyopia; Area; Behavioral; Brain; Cell Communication and Signaling; Cell Signaling; Complex; Decision Making; Development; Electrodes, Miniaturized; Elements; Encephalon; Encephalons; Environment and Public Health; Event; Eye; Eyeball; Frequencies (time pattern); Frequency; Goals; Human; Human, Adult; Human, General; Image; Individual; Infant; Intracellular Communication and Signaling; Investigation; Lazy Eyes; Life; Link; Macaca; Macaca mulatta; Macaque; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Methods; Microelectrodes; Monkeys; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Patients; Performance; Physiology; Prevention strategy; Preventive strategy; Primates; Process; Property; Property, LOINC Axis 2; Relative; Relative (related person); Research; Rhesus; Rhesus Macaque; Rhesus Monkey; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Space Perception; Spatial Discrimination; Staging; Stimulus; Structure; Testing; Time; V3 neuron; Vision Disorders; Visual; Visual Cortex; Visual Disorder; adult human (21+); base; biological signal transduction; experience; extrastriate; extrastriate visual cortex; imaging; infancy; infantile; insight; monocular; neural; neuron development; neuronal; perceptual spatial orientation; postnatal; public health relevance; receptive field; relating to nervous system; response; spatial orientation; spatial orientation (perception); spatial perception; vision development; visual cortical; visual development; visual performance; visual process; visual processing; visual system development",Amblyopia and study of cortical mechanisms, Project Narrative Amblyopia ('lazy eye') is a developmental vision disorder. This investigation proposes to explore the neuronal mechanisms in the primate visual brain that limit visual performance of amblyopic adults and normal infants using electrophysiological and behavioral methods. The primary goal is to establish a link between immature cortical physiology in normal infants and abnormal visual processing in amblyopic patients. The proposed research will generate the information that will have a significant impact on the development of effective strategies for the prevention and treatment of vision disorders.,8128,CVP,Central Visual Processing Study Section,A1,20,375000,
7784700,R01,EY,2,Y,02/01/2010,01/31/2011,PA-07-070,2R01EY011717-11A2,,NEI:390260;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,NUTRITION,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"SHANG, FU ;",1879409;,2R01EY011717,01/01/1998,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Age-Months; Antimorphic mutation; Antioxidants; Blindness; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cataract; Cell-Free System; Cellfree System; Cells; Chaperone; Cleaved cell; Crystallins; Data; Degradation Pathway; Degradative Pathway; Desminase; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Epithelial Cells; Excision; Extirpation; Eye diseases; Genotype; Grant; HMG-20; HSP; Heat shock proteins; High Mobility Protein 20; Impairment; Knowledge; Lens Proteins; Macropain; Macroxyproteinase; Maintenance; Maintenances; Methods; Mice, Transgenic; Molecular; Molecular Chaperones; Multicatalytic Proteinase; Names; Nuclear; Operation; Operative Procedures; Operative Surgical Procedures; Papain-Like Cysteine Protease; Pathway interactions; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Precipitation; Prevention strategy; Preventive Intervention; Preventive strategy; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Protein Binding; Proteins; Proteosome; Quality Control; Removal; Role; Stress Proteins; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Testing; Transgenic Mice; Ubiquitin; Work; age dependent; age related; anti-oxidant; base; cataractogenesis; cataractous lenses; cleaved; design; designing; eye disorder; gene product; in vivo; inhibitor; inhibitor/antagonist; lens; lens protein; lens transparency; multicatalytic endopeptidase complex; mutant; novel; ophthalmopathy; pathway; prevent; preventing; preventional intervention strategy; protein aggregation; repair; repair endonuclease; repair enzyme; repaired; resection; social role; surgery",Role of ubiquitin in quality control of lens proteins,"Cataract is the most common age-related eye diseases. Currently surgery is only effective methods to restore the vision loss caused by cataract. Elucidating the molecular mechanisms of cataract formation will help to develop safer, cheaper and more effective methods to prevent or treat agerelated cataract. During the last grant period we demonstrate that the ubiquitin-proteasome pathway is an important protein quality control mechanism in the lens. The selective degradation of various forms of damaged proteins by this pathway is important for preventing the accumulation and precipitation of damaged proteins in the lens. This proposed project will continue our work to demonstrate the critical role of the ubiquitin-proteasome pathway in maintaining lens transparency. Results from this project will help us to design new strategies for prevention and treatment of cataract.",11717,AED,Anterior Eye Disease Study Section,A2,11,390260,
7782129,R01,EY,2,,02/01/2010,01/31/2011,PA-07-070,2R01EY012859-12,,NEI:549577;,2010,NATIONAL EYE INSTITUTE,,DURHAM,UNITED STATES,OPHTHALMOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"ARSHAVSKY, VADIM Y;",1883880;,2R01EY012859,02/07/2000,01/31/2014,"Address; Adverse effects; Biochemical; Biogenesis; Biological Models; C-terminal; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Complex; Defect; Degenerative Disorder; Dependence; Destinations; Diffusion; Dysfunction; Functional disorder; Future; G-Protein, Inhibitory Gt; G-Proteins; GAP Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPase-Activating Proteins; GTPases; Goals; Golgi; Golgi Apparatus; Golgi Complex; Grant; Gt, Transducin G-Protein; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hereditary; Inherited; Intracellular Communication and Signaling; Investigation; Kinetic; Kinetics; Knock-out; Knockout; Light; Maintenance; Maintenances; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Mice, Transgenic; Model System; Models, Biologic; Molecular; Morphogenesis; Morphology; Organelles; Origin of Life; Outer Segment of the Photoreceptor Cell; Pathway interactions; Photoradiation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Phototransduction; Physiopathology; Programs (PT); Programs [Publication Type]; Protein Trafficking; Proteins; Reaction; Regulation; Research; Retina; Retinal Pigments; Rhodopsin; Rod; Rod Outer Segment of the Retina; Rod Outer Segments; Rod Photoreceptors; Rods (Eye); Rods (Retina); Role; Shapes; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Signaling Protein; Structural Protein; Subcellular Process; Surface; Surface Proteins; Testing; Therapeutic Intervention; Traffickings, Protein; Transducin; Transgenic Mice; Transport Vesicles; Treatment Side Effects; Visual Pigments; Visual Purple; Visual Receptor; Visual Transduction; Work; biological signal transduction; cell biology; computerized data processing; data processing; degenerative condition; degenerative disease; disc (rod outer segment); disease prevention; disorder prevention; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; guanosinetriphosphatase activating protein; in vivo; in vivo Model; interest; intervention therapy; membrane structure; mutant; pathophysiology; pathway; peripherin; photoreceptor cell outer segment; photoreceptor degeneration; photoreceptor disc; programs; protein complex; protein function; protein transport; public health relevance; research study; response; restoration; retina photosensitive pigment; rod cell; rod outer segment; side effect; signal processing; social role; therapy adverse effect; trafficking; transducin GTP phosphohydrolase; transducin GTPase; treatment adverse effect",Delivery of signaling and structural proteins to photoreceptor outer segment," The studies proposed in this application address the molecular and cellular mechanisms responsible for the functioning of the light-sensitive compartment of the photoreceptor cells, the outer segment. Because of adverse effects of daily light exposure, the building materials of the outer segment have to be replaced approximately every ten days, which requires an enormous flow of highly organized protein trafficking from the intracellular biosynthetic machinery to this compartment. Dysfunction of these pathways causes some of the most severe types of inherited degenerative diseases of the retina, highlighting the importance of understanding the mechanisms underlying protein signaling, trafficking and assembly into large functional complexes. Elucidating these mechanisms is essential for developing strategies for disease prevention and future therapeutic interventions.",12859,ZRG1,Special Emphasis Panel,,12,549577,
7783426,R01,EY,2,,02/01/2010,01/31/2011,PA-07-070,2R01EY015260-06A1,,NEI:392988;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,NEUROSCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GOLD, JOSHUA I;",1883233;,2R01EY015260,12/01/2003,01/31/2015,"Accounting; Afferent Neurons; Algorithms; Area; Associative Learning; Aves; Avian; Basal Ganglia; Basal Nuclei; Basic Research; Basic Science; Behavior; Behavioral; Birds; Brain; Candy; Caudate Nucleus; Caudate nucleus structure; Characteristics; Cognitive Discrimination; Computer Simulation; Computerized Models; Conditioning, Classical; Conditionings, Classical; Confection; Data; Decision Making; Diagnosis; Discrimination; Discrimination (Psychology); Disease; Disorder; Electrodes; Encephalon; Encephalons; Goals; Heterogeneity, Population; Human; Human, General; Image; Individual; Lateral; Learning; Link; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Monkeys; Motion; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurons, Afferent; Neurons, Sensory; Nucleus Caudatus; Outcome; Output; Pavlovian conditioning; Perceptual learning; Physiologic; Physiological; Physiology; Population; Population Heterogeneity; Process; Psychological reinforcement; Psychophysic; Psychophysics; Public Health; Punishment; Reinforcement; Reinforcement (Psychology); Research; Research Design; Rewards; Role; Scheme; Sensory; Sensory Cell Afferent Neuron; Shapes; Simulation, Computer based; Stimulus; Structure; Study Type; Techniques; Testing; Training; Visual; Visual Agnosias; Visual Motion; Visual Perception; Visual System; Visual system structure; Work; base; behavior measurement; behavioral measure; behavioral measurement; brain shape; caudate nucleus; classical conditioning; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease/disorder; diverse populations; experience; experiment; experimental research; experimental study; heterogeneous population; human subject; imaging; improved; in silico; innovate; innovation; innovative; insight; lateral intraparietal area; neural; neural mechanism; neuromechanism; neuronal; novel; public health medicine (field); public health relevance; relating to nervous system; research study; response; reward processing; social role; study design; virtual simulation; visual information; visual learning; visual stimulus",Mechanisms of learning a visual discrimination," Project Narrative The proposed work is basic research, designed to provide new insights into how a healthy nervous system learns from experience to more effectively process visual information. Thus, direct benefits to public health are intended to come in the longer term, as these new insights can be used to design new ways to diagnose and treat disorders of visual perception (i.e., visual agnosias) and learning.",15260,CVP,Central Visual Processing Study Section,A1,6,392988,
7781797,R01,EY,2,,02/01/2010,01/31/2011,PA-07-070,2R01EY015537-05A1,,NEI:524425;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MITCHELL, CLAIRE H;",1863799;,2R01EY015537,04/01/2004,01/31/2013,"Animal Model; Animal Models and Related Studies; Apoptotic; Blindness; Blood Coagulation Factor IV; Body Tissues; Ca++ element; Calcium; Cell Communication and Signaling; Cell Death; Cell Function; Cell Isolation; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Coagulation Factor IV; Common Rat Strains; Data; Disease; Disorder; Dysfunction; Ensure; Extracellular Space; Factor IV; Figs; Figs - dietary; Functional disorder; Funding; Ganglion Cells (Retina); Genes; Glaucoma; Grant; Health; Image; In Vitro; Injection of therapeutic agent; Injections; Injury; Intercellular Space; Intracellular Communication and Signaling; Intraocular Pressure; Investigation; Ions; Killings; Link; Location; Mammals, Rats; Mechanical Stimulation; Mechanics; Methods and Techniques; Methods, Other; Modeling; Ocular Tension; Participant; Pathway interactions; Physiologic; Physiologic Intraocular Pressure; Physiological; Physiopathology; Pressure; Pressure- physical agent; Purines; Rat; Rattus; Receptor Activation; Receptor Protein; Retina; Retinal; Retinal Ganglion Cells; Risk Factors; Role; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stretching; Subcellular Process; Swelling; Techniques; Tissues; Toxic effect; Toxicities; Vision; age effect; aging effect; base; biological signal transduction; cell damage; cell injury; cell sorting; cytotoxic; disease/disorder; experience; experiment; experimental research; experimental study; extracellular; gangliocyte; ganglion cell; glaucomatous; imaging; in vivo; in vivo Model; injured; innovate; innovation; innovative; insight; model organism; necrocytosis; neurotoxic; novel; patch clamp; pathophysiology; pathway; pressure; prevent; preventing; public health relevance; purine; receptor; research study; response; retinal ganglion; social role",Purines and the Health of Retinal Ganglion Cells, Narrative This project is based on the hypothesis that retinal ganglion cells are damaged in glaucoma by pressure-dependent release of excess ATP into the retina which stimulates P2X7 receptors on retinal ganglion cells. This proposal will confirm this relationship and explore how this pathological release occurs with the aim of preventing the initial stages of damage in glaucoma.,15537,AED,Anterior Eye Disease Study Section,A1,5,524425,
7784984,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM033998-25,,NIGMS:487918;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HANOVER,UNITED STATES,BIOCHEMISTRY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"COLE, CHARLES N.;",1889405;,2R01GM033998,08/01/1984,01/31/2014,"Abscission; Active Transport, Cell Nucleus; Address; Affect; Amino Acid Motifs; Antimorphic mutation; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Biochemical; Biochemistry; Biogenesis; Boxing; C-terminal; Cancers; Cardiac Diseases; Cardiac Disorders; Cell Components; Cell Nucleus; Cell Structure; Cells; Cellular Structures; Chemistry, Biological; Combining Site; Cytoplasm; Cytoplasmic Filaments; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Excision; Extirpation; Face; Filaments, Cytoplasmic; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Gene Expression; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Heart Diseases; Image; In Vitro; Inositol Hexakisphosphate; Inositol Hexaphosphate; Ligand Binding Protein; Link; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Molecular Interaction; Mutation; N-terminal; NH2-terminal; NPC; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Nuclear Pore Complex; Nuclear Pore Complex Proteins; Nuclear Transport; Nucleocytoplasmic Shuttling; Nucleoporins; Nucleus; Nup Protein; Origin of Life; Pathway interactions; Peptide Biosynthesis, Ribosomal; Photometry/Spectrum Analysis, Mass; Phytic Acid; Play; Point Mutation; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Motifs; Protein Synthesis, Ribosomal; Proteins; Proteomics; RNA, Messenger; RNA-Binding Proteins; RNA-dependent ATPase; Reactive Site; Removal; Research; Role; S cerevisiae; Saccharomyces cerevisiae; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Surgical Removal; Testing; Translations; Virus; Viruses, General; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; experiment; experimental research; experimental study; facial; gene product; genome mutation; heart disorder; human disease; imaging; in vivo; mRNA; mRNA Export; malignancy; mutant; myo-Inositol, hexakis(dihydrogen phosphate); neoplasm/cancer; nervous system disorder; neurological disease; nucleocytoplasmic transport; pathway; prevent; preventing; programs; protein complex; protein synthesis; public health relevance; receptor binding; research study; resection; social role",Nucleocytoplasmic Transport of mRNA in Yeast," PROJECT NARRATIVE: The transport of messenger RNA from its site of synthesis in the nucleus to its sites of translation in the cytoplasm is a fundamental step in gene expression. Understanding how mRNA export works is essential for a complete understanding of cellular structure and function. Many viruses exploit mRNA transport, either to prevent export of host mRNAs or to facilitate export of their own mRNAs or both. In addition, mutations affecting key mRNA export factors have been linked to human diseases include cancer, heart disease, and neurological disease.",33998,NCSD,,,25,487918,
7782405,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM035249-24A2,,NIGMS:339238;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,CHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MOLANDER, GARY A;",1884752;,2R01GM035249,09/01/1993,01/31/2014,"Acids; Alkanesulfonates; Alkyl Sulfonates; Alkylsulfonate Compound; B element; Biological Factors; Boron; Boronic Acids; C element; Carbon; Characteristics; Chemistry; Chemistry, Pharmaceutical; Chloride; Chloride Ion; Chlorides; Cl- element; Complex; Coupling; Development; Development and Research; Drugs; Electromagnetic, Microwave; Esters; Factor, Biologic; Foundations; Hydrogen Oxide; Investigation; Investigators; Ligands; Liquid substance; Medication; Medicinal Chemistry; Methods; Microwaves; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Organic Synthesis; Oxidants; Oxidizing Agents; Paper; Pattern; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphates; Plants; Plants, General; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publishing; R & D; R&D; Reaction; Reagent; Research; Research Personnel; Researchers; Role; Salts; Science of Chemistry; Solvents; Sonication; Structure; Technology; Time; United States National Institutes of Health; Water; base; catalyst; cost; drug discovery; drug/agent; electron acceptor; fluid; functional group; improved; infancy; infantile; inorganic phosphate; liquid; microwave electromagnetic radiation; microwave radiation; new technology; novel; programs; public health relevance; research and development; social role; success; sulfonate",Organotrifluoroborates in Selective Organic Synthesis," Success in the efforts proposed will provide enabling technologies for new drug discovery, and will also result in the development of robust synthetic transformations for the synthesis of complex target structures required for pharmaceutical process research and development, pilot plant technologies, and drug manufacturing. In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost.",35249,SBCB,Synthetic and Biological Chemistry B Study Section,A2,24,339238,
7736102,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM036700-25,,NIGMS:295484;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,CHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HOUK, KENDALL N;",1864232;,2R01GM036700,09/01/1998,01/31/2014,"Achievement; Achievement Attainment; Arts; Attention; Biology; Catalysis; Chemistry, Organic; Chemistry, Pharmaceutical; Collaborations; Colorado; Computer Programs and Programming; Computers; Computing Methodologies; Coupling; Development; Drug Synthesis and Chemistry; Goals; Grant; Health; Human; Human, General; Hydrogen Bonding; Hydrogenation; In element; Indium; Laboratories; Life; Ligands; Man (Taxonomy); Man, Modern; Mechanics; Medicinal Chemistry; Methods; Modeling; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organic Chemistry; Organic Synthesis; Pharmaceutic Chemistry; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Procedures; Process; Programs (PT); Programs [Publication Type]; Quantum Mechanics; Reaction; Reagent; Research; Research Resources; Resources; System; System, LOINC Axis 4; Testing; The Sun; Training; Transition Elements; United States National Institutes of Health; Universities; Washington; austin; catalyst; computational methodology; computational methods; computer methods; computer program; computer programming; conformation; conformational state; cycloaddition; design; designing; drug synthesis; flexibility; frontier; functional group; graduate student; new technology; programs; public health relevance; quantum; small molecule; stereochemistry; tool; transition metal",Stereoselectivities of Synthetic Organic Reactions," Project Narrative The goal of this research program is to develop and apply state-of-the-art computation methods to understand stereoselectivity and to design new stereoselective reagents and catalysts. The control of stereoselectivity is an essential feature of efficient synthesis, and this program provides explanations of the origins of these selectivities and builds on these to predict new reagents and catalysts for regioselective and stereoselective reactions. These are critical elements in the synthesis of effective pharmaceutical agents.",36700,SBCA,Synthetic and Biological Chemistry A Study Section,,25,295484,
7778773,R01,GM,2,,01/08/2010,11/30/2010,PA-07-070,2R01GM040922-25,,NIGMS:543261;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"ALLIS, CHARLES DAVID;",3214254;,2R01GM040922,07/01/1990,11/30/2013,"14-3-3 Family; 30 nm Chromatin Fiber; 30 nm Fiber; ADP ribosylation; ADP-Ribosyltransferase (Polymerizing); ATP[{..}]protamine O-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Acetylation; Affect; Amino Acids; Antibodies; Antisera; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Attention; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological; Biological Assay; Biological Models; Cancers; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cells; Centrosome; Chromatin; Chromatin Fiber; Chromosome Condensation; Chromosomes; Code; Coding System; Collaborations; Collection; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Data; Deoxyribonucleic Acid; Disease; Disorder; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Environment; Enzymatic Biochemistry; Enzymes; Enzymology; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equilibrium; Eukaryote; Eukaryotic Cell; Event; Experimental Models; Experimental Models, Other; Family member; Figs; Figs - dietary; Foundations; Funding; Future; Gel; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic, Biochemical; Genetics-Mutagenesis; Genome; Genome Stability; Genotoxic Stress; Glutamic Acid; Goals; Grant; HEK3; HP-1 protein; Health; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Histone Acetylation; Histone Code; Histone H2A; Histone Kinase; Histones; Human; Human Biology; Human Figure; Human body; Human, General; Immune Precipitation; Immune Sera; Immunoblotting; Immunoprecipitation; In Vitro; Interphase; Kinases; Kindling (Neurology); Kindlings (Neurology); Knock-out; Knockout; L-Glutamic Acid; Label; Laboratories; Libraries; Light; Link; Literature; M Phase; M phase (cell cycle); MSKCC; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Memorial Sloan-Kettering Cancer Center; Metabolic; Methods; Methylation; Micro-tubule; Microtubules; Mitosis; Mitosis Stage; Mitotic; Model System; Models, Biologic; Models, Experimental; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Mutate; Mutation; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; Nature; Nucleosomes; Oncogenesis; PARP Polymerase; PARS; PTK; Pattern; Peptide Fragments; Peptides; Phenotype; Phosphatases; Phosphates; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Photoradiation; Physical condensation; Physiologic; Physiological; Plasmids; Play; Point Mutation; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Polymers; Population; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protamine Kinase; Protein Methylation; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proteomics; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reaction; Reader; Reading; Reagent; Receptor Protein; Recombinants; Regulation; Research; Risk; Role; Saccharose; Scheme; Sequence-Specific Posttranscriptional Gene Silencing; Series; Site; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stability, Genomic; Stress, Genotoxic; Stretching; Sucrose; Suggestion; System; System, LOINC Axis 4; Tail; Testing; Time; To specify; Transcription; Transcription, Genetic; Transmission; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Unscheduled DNA Synthesis; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Work; Writing; Yang; Yeasts; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; aminoacid; aurora kinase; aurora-A kinase; auroraA kinase; balance; balance function; case-based; cell type; chemical group; combinatorial; condensation; cultured cell line; density; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; heterochromatin protein 1; heterochromatin-specific nonhistone chromosomal protein HP-1; histone modification; hydroxyaryl protein kinase; in vitro Assay; in vivo; inorganic phosphate; insight; interest; irradiation; kindling; knock-down; malignancy; member; mutant; neoplasm/cancer; novel; particle; poly ADP polymerase; poly ADP ribose synthetase; programs; protein structure; public health relevance; receptor; repair; repaired; research study; response; sensor; social role; stem; transmission process; tumorigenesis; tyrosyl protein kinase",Enzymology and Function(s) of Histone Phosphorylation," Project Narrative: Although every gene exists within every cell in the human body, only a small percentage of genes are active in any given cell type. Chromatin, DNA and associated histone proteins, is the physiological form of our genome. Dr. Allis and his colleagues favor the view that distinct patterns of covalent histone modifications (chemical groups such as phosphate) form a ""histone code"" that is then read by effector proteins to bring about distinct downstream events. Through such enzymatic processes, histones are believed to function like a master ""on/off"" switch to determine whether particular genes are active or inactive. Knowing how to control which genes to turn on or off, using therapy, could reduce the risk of certain diseases. The implications of this research for human biology and human health are far-reaching.",40922,MGC,Molecular Genetics C Study Section,,25,543261,
7785068,R01,GM,2,,02/01/2010,12/31/2010,PA-07-070,2R01GM041804-23,,NIGMS:305910;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"BRENNER, DAVID A;",6909729;,2R01GM041804,04/01/1989,12/31/2013,"2-Hydroxy-N,N,N-trimethylethanaminium; 5' Untranslated Regions; 5'UTR; Active Oxygen; Address; Alcoholic Liver Diseases; Amino Acids; Apoptosis; Apoptosis Pathway; Apoptotic; Bile Ducts; Bile duct structure; Binding; Binding (Molecular Function); CAP4 protease; CASP8 Protein; Cachectin; Cachectin Receptors; Cachectin-Tumor Necrosis Factor; Caspase-8/Flice; Cell Communication and Signaling; Cell Death; Cell Death Signaling; Cell Death Signaling Process; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Choline; Chronic; Circulatory Collapse; Closure by Ligation; Collagen; Collagen Gene; Collagen Type I; Diet; Dysfunction; EC 2.7; Embryo; Embryonic; Engineering; Engineerings; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Event; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Family member; Fibroblasts; Fibrosis; Functional disorder; Gene Expression; Genetic Alteration; Genetic Change; Genetic defect; Grant; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatic Stellate Cell; Hepatocyte; INFLM; Induction of Apoptosis; Inflammation; Inflammation Mediators; Inflammatory Response; Inhibition of Apoptosis; Intracellular Communication and Signaling; Ischemia-Reperfusion Injury; Ito Cell; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; Kinases; Knock-in; Knock-in Mouse; Kupffer Cells; Ligation; Liver; Liver Cells; Liver Fibrosis; Liver Regeneration; Liver diseases; MACH protein; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; Mammals, Mice; Mch5 protease; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mutation; Myofibroblast; NADPH Oxidase; NAFLD; NASH; Non-alcoholic steatohepatitis; Nucleic Acid Regulatory Sequences; Oxygen Radicals; PRKM8; PRKM9; Phosphorylation; Phosphotransferases; Physiopathology; Play; Population; Pro-Oxidants; Process; Production; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; RNA, Messenger; Reactive Oxygen Species; Receptor Signaling; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reperfusion Damage; Reperfusion Injury; Role; SAPK1; Shock; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Source; Stability, mRNA; Stellate Sinusoidal Macrophage; TNF (unspecified); TNF Receptor Family Protein; TNF Receptor Ligands; TNF Receptor Superfamily; TNF Receptors; TNF-alpha; TNFR; Testing; Transgenic Mice; Translations; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Type 1 Collagen; VESCL; Vesicle; Viral hepatitis; Wasting Disease; Wasting Syndrome; Whole Organism; Wound Healing; Wound Repair; alcohol induced hepatic injury; alcohol induced liver disorder; alcohol induced liver injury; alcohol-induced hepatic dysfunction; alcohol-induced liver disease; alcohol-induced liver dysfunction; alcohol-mediated liver dysfunction; alcohol-mediated liver injury; aminoacid; bile duct; bile ductule; biological signal transduction; body system, hepatic; caspase-8; cell type; circulatory shock; collagenase 1; cytokine; ethanol induced hepatic injury; ethanol induced liver disorder; ethanol induced liver injury; ethanol-induced hepatic dysfunction; ethanol-induced liver disease; ethanol-induced liver dysfunction; ethanol-mediated liver dysfunction; ethanol-mediated liver injury; feeding; gene product; genetic regulatory element; genome mutation; hepatic cell proliferation; hepatic cellular proliferation; hepatic fibrosis; hepatocyte cell proliferation; hepatocyte cellular proliferation; hepatocyte proliferation; hepatopathy; in vitro Assay; liver cell proliferation; liver cellular proliferation; liver disorder; liver macrophage; mRNA; mRNA Leader Sequences; mRNA Stability; mitochondrial membrane; necrocytosis; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; organ system, hepatic; p54aSAPK; pathophysiology; public health relevance; response; social role; stem; tissue repair; tumor; tumor necrosis factor (unspecified)",Molecular Mechanisms by which TNFalpha Modulates Fibrosis, Project Narrative Tumor necrosis factor (TNF)¨ is a multifunctional cytokine that is induced during inflammation and wound healing. TNF¨ has both anti-fibrotic effects on Type I collagen and pro-fibrotic effects on activating myofibroblasts. This proposal uses the wound healing model of hepatic fibrosis to assess how TNF¨ modulates wound healing through different signal transduction pathways in the whole organism and in specific hepatic cell populations.,41804,SAT,"Surgery, Anesthesiology and Trauma Study Section",,23,305910,
7808024,R01,GM,2,,01/04/2010,12/31/2010,PA-07-070,2R01GM042564-21A1,,NIGMS:381250;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBUS,UNITED STATES,GENETICS,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"OSMANI, STEPHEN A;",1891746;,2R01GM042564,07/01/1989,12/31/2013,"Affect; Affinity Chromatography; Animal Model; Animal Models and Related Studies; Aspergillus; Aspergillus nidulans; Biological Models; Biology; Birth Defects; Cancer Treatment; Cancers; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Nucleolus; Cells; Chromatin; Chromatography, Affinity; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; Data; Defect; Deoxyribonucleic Acid; Disease; Disorder; Drosophila; Drosophila genus; Drugs; EC 2.7; Event; Fruit Fly, Drosophila; Fungi, Filamentous; Gene Transcription; Genetic Transcription; Human; Human, General; Integral Membrane Protein; Interphase; Intrinsic Membrane Protein; Kidney Diseases; Kinases; Location; M Phase; M phase (cell cycle); Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medical; Medical Research; Medication; Medicine; Membrane Proteins; Membrane-Associated Proteins; Messenger RNA; Mitosis; Mitosis Stage; Mitotic; Model System; Modeling; Models, Biologic; Molds; Molecular Genetic Abnormality; NIMA; NIMA protein kinase; NIMA-related protein kinase; NPC; Nephropathy; Nuclear Envelope; Nuclear Membrane; Nuclear Pore Complex; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Plasmosome; Play; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Protein Motifs, DNA-Binding; Protein Phosphorylation; Proteins; Public Health; RNA Expression; RNA Transport; RNA, Messenger; Racial Segregation; Regulation; Renal Disease; Research; Research, Medical; Ribonucleic Acid Transport; Role; Science of Medicine; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Surface Proteins; TM Domain; Testing; Transcription; Transcription, Genetic; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Transphosphorylases; Vertebrate Animals; Vertebrates; affinity purification; anticancer therapy; cancer progression; cancer therapy; cell killing; combat; disease/disorder; drug/agent; experiment; experimental research; experimental study; fruit fly; gene product; in vivo; insight; kidney disorder; mRNA; mRNA Export; malignancy; member; model organism; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; nucleolus; pathogen; programs; public health medicine (field); public health relevance; renal disorder; research study; segregation; social role; trafficking; tumor progression; vertebrata",The role of the NIMA kinase in mitotic regulation," Project Narrative How the cell cycle is regulated is of fundamental medical importance because when this regulation goes awry disease states such as birth defects and cancer can result. In addition, many current cancer treatments target different aspects of cell cycle regulation to preferentially kill cells actively passing through the cell cycle. Therefore in terms of public health, the more we understand how the cell cycle is regulated the better positioned we will be to develop drugs against new chemotherapeutic targets to combat diseased states associated with cell cycle defects. The experiments proposed will in addition further our understanding of the NIMA kinase human orthologues of which are involved in specific disease states (kidney disease). Finally, A. nidulans is the model organism of the Aspergilli. Insights to the biology of A. nidulans will impact research on the opportunistic Aspergillus pathogens as well as members being used to generate new pharmacologically active compounds.",42564,NCSD,,A1,21,381250,
7781054,R01,GM,2,,02/01/2010,12/31/2010,PA-07-070,2R01GM048430-17A1,,NIGMS:359231;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ITHACA,UNITED STATES,BIOCHEMISTRY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"GOLDBERG, MICHAEL L;",1968870;,2R01GM048430,09/30/1992,12/31/2013,"Assay; Bioassay; Biochemical; Biochemical Pathway; Biologic Assays; Biological Assay; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cells; Cyclin B; Dephosphorylation; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7; Ensure; Event; Family; G2/M Transition; Generations; Goals; Histone H1 Kinase, Growth-Associated; Histone H1 Kinase, M-Phase-Specific; In Vitro; Interphase; Investigation; Kinases; Laboratories; M Phase; M Phase Arrest; M Phase-Promoting Factor; M phase (cell cycle); Maintenance; Maintenances; Maturation-Promoting Factor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Networks; Methods; Mitosis; Mitosis Stage; Mitosis-Promoting Factor; Mitotic; Oocytes; Ovocytes; P62 (cyclin B); PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTPA; Pathway interactions; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Phosphotyrosyl Phosphatase Activator; Play; Protein Dephosphorylation; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Phosphorylation; Proteins; Regulation; Role; Site; Specificity; Structure; Substrate Specificity; Testing; Transphosphorylases; Xenopus; base; cdc13 Protein; egg; gene product; maturation promoting factor; novel; p56cdc13; pathway; prevent; preventing; public health relevance; social role",Greatwall Kinase and the Mitotic Control of Phosphatase Activity, Project Narrative: We have previously shown that Greatwall kinase promotes M phase entry and maintenance in Xenopus egg extracts. The major goal of this project is to define the biochemical pathway through which the activation of Greatwall during M phase leads to the inactivation of a form of the phosphatase PP2A that would otherwise remove phosphorylations required for the mitotic state.,48430,CSRS,Cellular Signaling and Regulatory Systems Study Section,A1,17,359231,
7779741,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM049758-16,,NIGMS:316699;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,CHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"CHRISTIANSON, DAVID W;",1885766;,2R01GM049758,05/01/1994,01/31/2014,"2,5-Diaminopentanoic Acid; 7-(N-(3-aminopropyl)amino)heptan-2-one; APAH; Affinity; Amidases; Amides; Amidohydrolases; Amino Acid Sequence; Arginine; Arginine, L-Isomer; Asthma; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bears; Binding; Binding (Molecular Function); Biology; Biosensor; Body Tissues; Bronchial Asthma; CO2; Cancers; Carbamide; Carbon Dioxide; Carbonic Anhydride; Catalysis; Cells; Chemicals; Chemistry; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Clinical; Combination Chemotherapy Regimen; Complex; Crystallization; Deacetylase; Detection; Development; Diagnosis; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Early Diagnosis; Elaqua XX; Employee Strikes; Engineering; Engineerings; Enzymes; Erectile dysfunction; Evolution; Explosion; Family; Goals; Guanidine; HDAC; HDAC Proteins; Hepatic Proliferation Inhibitor; Histone Deacetylase; Histones; Human; Human, General; Hydrolysis; Hydroxide Ion; Image; Ions; L Forms; L arginine amidinohydrolase; L-Arginine; Laboratories; Link; Liver Immunoregulatory Protein; Liver-Derived Inhibitory Protein; Malaria; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Manganese; Measurement; Medication; Metal Binding Site; Metals; Michigan; Mn element; Molecular Interaction; Ornithine; Paludism; Parasites; Pathology; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmodium Infections; Plasmodium falciparum; Polyamine Compound; Polyamines; Programs (PT); Programs [Publication Type]; Protein Structure, Primary; Quimioterapia; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Research; Resolution; Roentgen Rays; Science of Chemistry; Shapes; Site; Specificity; Strikes; Strikes, Employee; Structure; Structure-Activity Relationship; Tissues; Universities; Urea; Urea Carbamide; Ureaphil; Ursidae; Ursidae Family; Variant; Variation; X-Radiation; X-Rays; Xrays; Yang; Zea; amidinohydrolase; arginase; arginine amidinase; atheromatosis; atherosclerotic vascular disease; base; canavanase; cancer chemotherapy; chemical structure function; design; designing; disease/disorder; drug/agent; early detection; enzyme activity; enzyme structure; guanidinium; human disease; hydroxide; hydroxyl ion; imaging; in vivo; inhibitor; inhibitor/antagonist; interest; malignancy; metalloenzyme; neoplasm/cancer; new approaches; novel approaches; novel strategies; novel strategy; pathway; professor; programs; protein sequence; public health relevance; sensor (biological); stoichiometry; structure function relationship",Engineering Manganese Metalloenzymes," Structural and functional studies of human arginase I, human histone deacetylase-8, and bacterial polyamine deacetylase will facilitate the design of potential new drugs that can be used to treat atherosclerosis, asthma, and cancer. Additionally, our studies will enable the design and development of biosensors that may be useful in the early diagnosis of human disease.",49758,MSFA,Macromolecular Structure and Function A Study Section,,16,316699,
7791862,R01,GM,2,,03/01/2010,02/28/2011,PA-07-070,2R01GM049883-17,,NIGMS:355697;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SANTA CRUZ,UNITED STATES,BIOCHEMISTRY,17,125084723,US,CA,95064,UNIVERSITY OF CALIFORNIA SANTA CRUZ,"TAMKUN, JOHN WALTER;",1901212;,2R01GM049883,08/01/1993,02/28/2014,"30 nm Chromatin Fiber; 30 nm Fiber; Address; Affect; Animal Model; Animal Models and Related Studies; Biochemical; Biological; Birth; Birth Defects; CHARGE (coloboma-heart disease-atresia of choanae-retarded mental development and growth-genital hypoplasia-ear abnormalities-deafness) association or syndrome; CHARGE syndrome; Cancers; Cell Fate Control; Cell Fate Regulation; Cells; Cellular Regulation; Chromatin; Chromatin Fiber; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Chromatin Structure; Chromosomes; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA; DNA Packaging; Deoxyribonucleic Acid; Development; Disease; Disorder; Drosophila; Drosophila genus; Drosophila melanogaster; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Eukaryota; Eukaryote; Eukaryotic Cell; Flies; Fruit Fly, Drosophila; Gene Down-Regulation; Gene Expression; Gene Inactivation; Gene Silencing; Gene Transcription; Genes; Genes, Homeo Box; Genes, Homeobox; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic Transcription; Genetic defect; Goals; HOX gene; Health; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Histone H1; Histone H1(s); Histone H3; Histones; Homeobox Family Gene; Homeobox Genes; Homeodoamin Gene; Homeotic Genes; Human; Human, General; ISWI; ISWI protein; Imitation Switch; In Vitro; L-Lysine; Laboratories; Lead; Learning; Linker DNA; Lysine; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods; Methylation; Modification; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Mutation; Nucleosomal Linker; Nucleosomes; Organism; Parturition; Pb element; Play; Polycomb; Position; Positioning Attribute; Process; Protein Methylation; Proteins; RNA Expression; Recruitment Activity; Regulatory Protein; Repression; Role; Structure; Testing; Transcription; Transcription Elongation; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Work; cell growth regulation; chromatin modification; chromatin remodeling; developmental disease/disorder; developmental disorder; disease/disorder; eukaryotida; fly; fruit fly; gene product; gene repression; genetic regulatory protein; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; human disease; in vivo; living system; malignancy; model organism; neoplasm/cancer; pluripotency; prevent; preventing; public health relevance; recruit; regulatory gene product; social role; transcription factor",Genetic and molecular studies of Drosophila chromatin remodeling factors," PROJECT NARRATIVE This goal of this project is to understand how Drosophila chromatin-remodeling factors, including KIS-L and ISWI, control gene expression and development by altering chromatin structure. Mutations in the human counterparts of these proteins are responsible for numerous cancers and birth defects, including CHARGE syndrome, a serious developmental disorder affecting 1 in 8,000 births. The information gained from this project will therefore be directly relevant to human health.",49883,MGB,Molecular Genetics B Study Section,,17,355697,
7782623,R01,GM,2,,01/18/2010,11/30/2010,PA-07-070,2R01GM052072-14A2,,NIGMS:307455;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"CURCIO, M JOAN ;",1887104;,2R01GM052072,08/01/1995,11/30/2013,"2',3'-exoribonuclease; 3'-exoribonuclease; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Affect; Assay; Bioassay; Biogenesis; Biologic Assays; Biological Assay; Biological Models; Capsid Proteins; Cells; Coat Proteins; Collection; Complement; Complement Proteins; Complementary DNA; Complex; Coupled; DNA; DNA, Complementary; Decay, mRNA; Defect; Degradation Pathway; Degradation, mRNA; Degradative Pathway; Deoxynucleotide-triphosphate[{..}]DNA deoxynucleotidyltransferase (RNA-directed); Deoxyribonucleic Acid; Dependency; Dependency (Psychology); Development; Drugs; EC 2.7.7.49; Elements; Endomycetales; Exonuclease; Family; Fungal Genome; Gene Products, RNA; Gene Transcription; GeneHomolog; Genetic; Genetic Transcription; Genetic Translation; Genome; Genome, Fungal; Genomics; Genotoxins; Goals; Grant; HIV-1; HIV-I; HIV1; Holoenzymes; Homolog; Homologous Gene; Homologue; Host Factor; Host Factor Protein; Human; Human immunodeficiency virus 1; Human, General; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Initiation Factors; Integration Host Factors; Long Terminal Repeats; Man (Taxonomy); Man, Modern; Mediating; Medication; Messenger RNA; Model System; Models, Biologic; Molecular; Mutagens; Nature; Nonsense-Mediated Decay; Organism; Origin of Life; Ortholog; Orthologous Gene; Parasites; Pathway interactions; Peptide Initiation Factors; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Process; Proteins; RNA; RNA Expression; RNA Transcriptase; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Dependent DNA Polymerase; RNA-Directed DNA Polymerase; RNP; Regulation; Retroelements; Retrotransposition; Retrotransposon; Retroviridae; Retroviruses; Reverse Transcriptase; Reverse Transcription; Revertase; Ribonucleic Acid; Ribonucleoproteins; Ribosomal Proteins; Ribosomes; Role; S cerevisiae; Saccharomyces cerevisiae; Saccharomycetales; Saccharose; Sucrose; Terminal Repeats, Long; Transcription; Transcription, Genetic; Translation Initiation Factor; Translational Inhibition; Translational Initiation Factor; Translational Regulation; Translational Repression; Translations; Viral Coat Proteins; Viral Outer Coat Protein; Virus; Virus-Retrovirus; Virus-like particle; Viruses, General; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; antiretroviral therapy; cDNA; drug/agent; emotional dependency; experiment; experimental research; experimental study; gene product; genotoxic agent; human T cell leukemia virus III; human T lymphotropic virus III; human disease; living system; long terminal repeat, nucleic acid; mRNA; mRNA Decay; mRNA Transcript Degradation; mRNA Translation; mRNA decapping; mutant; paralog; paralogous gene; particle; pathogen; pathway; poly A specific exoribonuclease; public health relevance; research study; small molecule; social role; success; viruslike particle; yeast genome",Regulation of Retrotransposition in S. cerevisiae," Project Narrative Retroviruses are a type of infectious virus that are the known or suspected causative agents in a variety of human diseases, including AIDS. This proposal uses a simple organism, budding yeast, to illuminate the role of cellular proteins that are necessary for replication of retroviruses in human cells. Cellular proteins that are required for retroviral replication are potential targets for the development of new drugs to treat AIDS.",52072,MGC,Molecular Genetics C Study Section,A2,14,307455,
7780602,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM052581-14A1,,NIGMS:427559;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"BASERGA, SUSAN J;",1934387;,2R01GM052581,02/01/1996,01/31/2014,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Architecture; Biochemical; Biogenesis; Boxing; Cancers; Cannot achieve a pregnancy; Cell Nucleolus; Cells; Chemicals; Cirrhosis; Complex; D-Ribose; Data; Difficulty conceiving; Electron Microscopy; Electrons; Engineering / Architecture; Eukaryote; Eukaryotic Cell; Event; Gene Expression; Gene Probes, RNA; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetics, Human; Glycerin; Glycerol; Goals; Hereditary Disease; Human; Human Genetics; Human, General; Infertility; Intermediary Metabolism; Link; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mediating; Metabolic Processes; Metabolism; Methylation; Microscopic; Modification; Molecular Disease; Multiple Neurofibromas; Mutation; Negative Beta Particle; Negatrons; Neonatal; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis Syndrome; Origin of Life; Pathogenesis; Plasmosome; Pre-rRNA; Process; Protein Methylation; Proteins; RNA Conformation; RNA Folding; RNA Metabolism[{..}] Processing and Transport; RNA Probes; RNA Processing; RNA, Ribosomal, Precursors; Research; Ribose; Ribosomal Proteins; Ribosomal RNA; Ribosomes; S cerevisiae; Saccharomyces cerevisiae; Small Nucleolar Ribonucleoproteins; Structure; Testing; Time; Translations; Two Hybrid; U3 small nuclear ribonucleoprotein; U3 snRNP; U3 snoRNP; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeast, Baker's; Yeast, Brewer's; Yeasts; design; designing; eukaryotida; gel electrophoresis; gene product; genetic disorder; genome mutation; hereditary disorder; in vivo; infertile; innovate; innovation; innovative; insight; macromolecular assembly; macromolecule; malignancy; neoplasm/cancer; nucleolus; particle; protein complex; public health relevance; rRNA; rRNA Precursor; reconstitute; reconstitution; ribonucleoprotein, U3 small nucleolar; snoRNP; success; unable to bear children; yeast two hybrid system",The Architecture and Function of RNPs Required for Ribosome Biogenesis, 7. Project Narrative This proposal is designed to answer important questions about the function and organization of protein and RNA-protein complexes that have been implicated in the pathogenesis of cancer and several rare human genetic diseases. A more thorough understanding of these processes will help us design better therapies for malignancies.,52581,MGC,Molecular Genetics C Study Section,A1,14,427559,
7782594,R01,GM,2,,01/15/2010,12/31/2010,PA-07-070,2R01GM052932-12,,NIGMS:361550;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,ZOOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"BEMENT, WILLIAM ;",1939103;,2R01GM052932,03/01/1997,12/31/2013,"ATPase, Actin-Activated; Actin Filaments; Actomyosin; Address; Adenosine Triphosphatase, Myosin; Area; Back; Bears; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Signaling; Cell division; Cells; Cellular injury; Characteristics; Chromosomes; Clinical; Cues; Cytokinesis; Cytoplasmic Division; DISSEC; Diffusion; Disease; Disorder; Dissection; Dorsum; EC 2.7; Event; Exocytosis; F-Actin; Feedback; Feeds; Filamentous Actin; Goals; Heart; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinases; Link; Lipids; Mediating; Microfilaments; Mitotic spindle; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Motor; Muscular Dystrophies; Myodystrophica; Myodystrophy; Myofilaments; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Oncogenesis; Phenotype; Phosphotransferases; Process; Proteins; Research Design; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small G-Proteins; Small GTPases; Speed; Speed (motion); Structure; Study Type; Testing; Transphosphorylases; Ursidae; Ursidae Family; Work; Wound Healing; Wound Repair; base; biological signal transduction; cell damage; cell injury; design; designing; disease/disorder; experiment; experimental research; experimental study; flexibility; gene product; innovate; innovation; innovative; insight; interventional strategy; myosin ATP phosphohydrolase (actin translocating); public health relevance; repair; repaired; research study; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; social role; study design; tissue repair; tumorigenesis; wound",Transient cytoskeletal arrays," PROJECT NARRATIVE The proposed studies are designed to address three areas that are poorly understood and yet highly important: The first concerns how single cells repair themselves, a process which is at the heart of the muscular dystrophies; The second and third concern basic mechanisms that control cell division, a process which is at the heart of tumorigenesis. This work will provide cellular and molecular insights into these processes which will permit informed design of clinical interventions for these diseases.",52932,NCSD,,,12,361550,
7779135,R01,GM,2,,01/29/2010,11/30/2010,PA-07-070,2R01GM055188-13A1,,NIGMS:300860;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,PATHOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"TIMCHENKO, NIKOLAI A;",1884590;,2R01GM055188,09/01/1997,11/30/2013,"5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Address; Animals; Assay; BUdR; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Birth; Blotting, Western; Body Tissues; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; C-EBP Nuclear Protein; C-EBP Proteins; C-EBP alpha; C-EBPalpha; C/EBP; C/EBP-alpha; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Proteins; CCND1 Protein; CEBP; CEBPA; CEBPA gene; Cell Cycle; Cell Cycle Genes; Cell Cycle Proteins; Cell Division Cycle; Cell Division Cycle Proteins; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell-Cycle Regulatory Proteins; Cellular Proliferation; Chromatin Structure; Chromatin Structure Alteration; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chromatography, Molecular Sieve; Complex; Cyclin D1; DNA Binding; DNA Binding Interaction; Development; Differentiation and Growth; EC 2.7; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Figs; Figs - dietary; Funding; G1/S-Specific Cyclin D1; Generalized Growth; Generations; Genes; Genes, Cell Division Cycle; Genes, cdc; Growth; HD1; HDAC1; HDAC1 gene; HPLC; Hepatic Cells; Hepatic Mass; Hepatic Parenchymal Cell; Hepatocyte; High Pressure Liquid Chromatography; Hour; Inhibition of Cell Proliferation; Injury; Investigation; Isoforms; Kinases; Knock-in; Knock-in Mouse; Laboratories; Learning; Limulus factor C; Liver; Liver Cells; Liver Mass; Liver Regeneration; Liver neoplasms; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Mediating; Methods and Techniques; Methods, Other; Mice; Mitotic; Molecular; Molecular Sieve Chromatography; Molecular Weight; Monitor; Murine; Mus; Natural regeneration; Negative Control of Cell Proliferation; Negative Regulation of Cell Proliferation; Neoplasms, Hepatic; Nucleus; Operation; Operative Procedures; Operative Surgical Procedures; PRAD1 Protein; Partial Hepatectomy; Parturition; Pathway interactions; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Play; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-1; RNA, Small Interfering; RPD3; RPD3L1; Regeneration; Regulation; Repression; Resistance; Role; Signal Transduction Pathway; Size Exclusion Chromatography; Small Interfering RNA; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Staining method; Stainings; Stains; Sum; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Testing; Therapeutic; Time; Tissue Growth; Tissues; Transphosphorylases; Uridine, 5-bromo-2'-deoxy-; Western Blotting; Western Blottings; Western Immunoblotting; Work; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; body system, hepatic; c-bcl-1 Proteins; cdc Genes; cdc Proteins; chromatin remodeling; cyclin D; cyclin D3; factor C; gene product; hepatic neoplasia; hepatic neoplasm; horseshoe crab factor C; inhibitor; inhibitor/antagonist; liver tumor; member; mutant; ontogeny; organ system, hepatic; partial excision of liver; pathway; postnatal; prenatal; prevent; preventing; protein blotting; protein complex; public health relevance; regenerate; resistant; response; restoration; siRNA; social role; subtotal hepatectomy; surgery; transcription factor; tumor; unborn; uptake",Molecular mechanisms of C/EBP alpha mediated growth arrest, Project Narrative This project investigates the mechanisms of liver growth and differentiation. The primarily focus of the application is transcription factor C/EBP¨. The application examines mechanisms by which C/EBP¨ inhibits liver proliferation; mechanisms by which livers neutralize the inhibitory activity of C/EBP¨ when livers proliferate; and the role of C/EBP¨ in termination of liver regeneration when liver reaches original size. The elucidation of these mechanisms will provide basement for the generation of therapeutic approaches to prevent tumors.,55188,HBPP,Hepatobiliary Pathophysiology Study Section,A1,13,300860,
7790862,R01,GM,2,,01/11/2010,12/31/2010,PA-07-070,2R01GM055989-13,,NIGMS:408900;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"TONKS, NICHOLAS K;",1902938;,2R01GM055989,05/01/1997,12/31/2013,"ATP[{..}]protein-tyrosine O-phosphotransferase; Abscission; Active Sites; Animal Model; Animal Models and Related Studies; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Bypass; Cancer Genes; Cancer Model; Cancer Treatment; Cancer of Breast; Cancer-Promoting Gene; CancerModel; Cancers; Categories; Causality; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cells; Cellular Migration; Chemotherapy-Hormones/Steroids; Cytoplasmic Membrane; Cytosolic Protein Tyrosine Phosphastase; Development; Diabetes Mellitus; Differentiation and Growth; Disease; Disorder; Drugs; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endocrine Gland Secretion; Environment; Enzymes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Equilibrium; Etiology; Event; Excision; Extirpation; Family; Funding; GFAC; Generalized Growth; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H2O2; HEK3; Hormones; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; INFLM; Individual; Inflammation; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; Laboratories; Laboratory Study; METBL; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Marketing; Measures; Mediating; Medication; Metabolic Processes; Metabolism; Motility; Motility, Cellular; Movement; Natural regeneration; O element; O2 element; Oncogenes; Oxygen; PTK; PTP-1B; PTP1B; PTPN1; PTPN1 gene; PTPRT protein, human; PTPase; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatases; Phosphates; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Physiologic; Physiological; Plasma Membrane; Process; Production; Programs (PT); Programs [Publication Type]; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Phosphatase; Protein Tyrosine Phosphatase Receptor Type T; Protein phosphatase; Proteins; R-PTP-T; RPTP Rho; Receptor Protein Tyrosine Phosphatase; Regeneration; Regulation; Removal; Research; Research Resources; Resources; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Sites, Active; Stimulus; Structure; Surgical Removal; Therapeutic; Therapeutic Hormone; Thioredoxin; Tissue Growth; Transforming Genes; Transphosphorylases; Tyrosine Kinase; Tyrosine Phosphatase; Tyrosine Phosphorylation; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosyl Phosphoprotein Phosphatase; Tyrosylprotein Kinase; anticancer therapy; balance; balance function; biological signal transduction; biomarker; body movement; cancer therapy; cell motility; chemical property; cytokine; diabetes; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug development; drug/agent; enzyme activity; gene product; human PTPRT protein; human disease; hydroxyaryl protein kinase; in vivo; infancy; infantile; inorganic phosphate; insight; malignancy; malignant breast neoplasm; model organism; neglect; neoplasm/cancer; new approaches; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; ontogeny; oxidation; plasmalemma; programs; protein tyrosine phosphate phosphohydrolase; public health relevance; receptor function; receptor protein tyrosine phosphatase rho; regenerate; resection; response; senescence; social role; success; therapeutic target; tool; tyrosyl protein kinase","Receptor PTPs, Cell Contact & Signal Transduction"," PROJECT NARRATIVE  Each cell is surrounded by a plasma membrane that represents a barrier to the outside world. However, the cell must be able to respond to changes in its external environment. This laboratory studies a process termed signal transduction, which is the mechanism by which cells register environmental stimuli and respond by changing their growth, differentiation, survival, movement or metabolism. The reversible addition and removal of phosphate to proteins, which is termed protein phosphorylation, is a crucial aspect of the mechanism of signal transduction. The activities of the enzymes that mediate the addition (kinases) and removal (phosphatases) of phosphate groups are coordinated in signal transduction pathways to mediate the cellular response to environmental stimuli and the function of these enzymes is frequently disrupted in human diseases, including cancer. This laboratory focuses on the family of signal transducing protein phosphatases known as Protein Tyrosine Phosphatases (PTPs) and their role in human disease. The characterization of the PTPs is a prerequisite to gaining a complete understanding of the physiological consequences of tyrosine phosphorylation and how such signaling events are abrogated in disease.  The ability to modulate signal transduction pathways selectively holds enormous therapeutic potential. The first drugs directed against protein tyrosine kinases (PTKs) have now entered the market and represent breakthroughs in cancer therapy. However, the success rate is limited and these approaches remain in their infancy. The development of novel strategies to interrogate such protein phosphorylation-dependent signaling pathways will have a profound impact on drug development in cancer. In this context, the PTPs remain a largely untapped resource that can be exploited to reveal new insights into the regulation of signal transduction. It is now known that a wide variety of stimuli, including growth factors, hormones and cytokines, trigger the controlled production of reacive oxygen species (ROS), particularly hydrogen peroxide. This results in the reversible oxidation and inactivation of those PTPs that provide inhibitory constraint upon the signaling pathway. This mode of regulation, which is the focus of this proposal, applies broadly across the PTP family as a whole and as such reflects a new tier of control over tyrosine phosphorylation-dependent signaling under normal and pathophysiological conditions. We have developed novel assays to measure PTP oxidation in cells, which, together with various tools we have developed for analysis of PTP function, will be integrated with state of the art cell and animal models, to define critical tyrosine phosphorylation-dependent signaling events in cancer. By doing so we will open up unique perspectives on tyrosine phosphorylation-dependent signal transduction that will allow us to identify novel therapeutic targets and biomarkers from among the PTPs themselves or from within those signaling pathways that they regulate. Furthermore, although there is excitement in the field regarding the potential of the PTPs themselves as therapeutic targets, it is also clear that, due to the chemical properties of the PTP active site, they are challenging targets for drug development. The characterization of the regulatory role of reversible PTP oxidation may also suggest new therapeutic strategies for inhibition of the PTPs.",55989,CSRS,Cellular Signaling and Regulatory Systems Study Section,,13,408900,
7778852,R01,GM,2,,01/15/2010,11/30/2010,PA-07-070,2R01GM057035-13,,NIGMS:518419;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"BLOCK, STEVEN M;",1885410;,2R01GM057035,09/30/1997,11/30/2013,"1H-Purin-6-amine; ATPase, Actin-Activated; Address; Adenine; Adenosine Triphosphatase, Myosin; Ally; Arm; Assay; Bacterial RNA; Base Pairing; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Biology; Buffers; Catalysis; Catalytic RNA; Cells; Characteristics; Chemicals; Codon, Initiation; Codon, Initiator; Codon, Start; Communicable Diseases; Complement; Complement Proteins; Complex; DNA; DNA Helicases; DNA Polymerase II; DNA Polymerase epsilon; DNA Sequence; DNA Unwinding Proteins; DNA unwinding enzyme; DNA-Dependent DNA Polymerase II; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Deoxyribonucleic Acid; Development; Devices; Disease; Disorder; Docking; E coli; EC 2.7.7.6; Elements; Enzymes; Escherichia coli; Eukaryota; Eukaryote; Fluorescence; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Genes; Genes, Regulator; Genetic; Genetic Diseases, Inborn; Genetic Transcription; Goals; Grant; Homolog; Homologous Gene; Homologue; Human; Human Virus; Human, General; Inborn Genetic Diseases; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inherited disorder; Initiator Codon; Instrumentation, Other; Investigation; Isomerase; Knowledge; Lead; Libraries; Life Extension; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanics; Methods; Methods and Techniques; Methods, Other; Microfluidic; Microfluidics; Model System; Models, Biologic; Molecular; Molecular Interaction; Molecular Machines; Motion; Motor; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Nature; Nucleic Acids; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleotides; Optics; Pb element; Phase; Play; Pol II; Polymerase; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Family; Proteins; Quartz; Quartz (SiO2); RNA; RNA Expression; RNA Folding; RNA Polymerases; RNA, Bacterial; RNA, Non-Polyadenylated; Recombinants; Regulation; Regulator Genes; Research; Research Proposals; Resolution; Reticuloendothelial System, Thymus; Ribonucleic Acid; Ribosomes; Ribozymes; Role; SII transcription elongation factor; Scanning; Series; Structure; Surface; System; System, LOINC Axis 4; TFIIF; TFIIS; TFIIS elongation factor; Techniques; Technology; Thymus; Thymus Gland; Thymus Proper; Time; Torque; Transcript; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Translating; Translatings; Translation Initiation; Travel; Tweens; Upper arm; Variant; Variation; Vitamin B4; Work; Yeasts; base; capping of mRNA; copolymer; design; designing; disease/disorder; elongation factor SII; eukaryotida; experiment; experimental research; experimental study; gene product; hairpin ribozyme; hammerhead ribozyme; heavy metal Pb; heavy metal lead; helicase; human disease; improved; inborn error; insight; instrument; instrumentation; interest; language translation; mRNA capping; macromolecule; metrology; mutant; myosin ATP phosphohydrolase (actin translocating); nano fabricate; nano fabrication; nano meter scale; nano meter sized; nano scale; nano science; nanofabricate; nanofabrication; nanomechanical; nanometer scale; nanometer sized; nanoscale; nanoscience; next generation; nucleic acid structure; optical traps; pathogen; programs; public health relevance; regulatory gene; research study; single molecule; social role; strand transfer protein alpha; time interval; trans acting element; transcription elongation factor A; transcription elongation factor S-II; transcription factor IIS; transcription factor S-II; transcription factor TFIIF",Nucleic Acid Enzymes and Nucleic Acids Studied at the Molecular Level," Relevance:  Understanding  the  process  of  gene  regulation  is  fundamental  to  any  understanding  of  disease,  because  undesired  changes  in  gene  expression  are  responsible for the overwhelming majority of developmental and inherited disorders.  Furthermore, many communicable diseases, especially those caused by human viruses,  typically involve disruptions of gene regulation produced by the pathogen itself. The  work described in this research proposal will supply new insights into the molecular  basis  of  gene  regulation  by  studying,  at  the  single-molecule  level,  important  gene- control molecules such as RNA polymerases, ribosomes, ribozymes, and riboswitches. ",57035,ZRG1,Special Emphasis Panel,,13,518419,
7807632,R01,GM,2,,02/01/2010,11/30/2010,PA-07-070,2R01GM062939-09,,NIGMS:488377;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GUNDERSEN, GREGG G;",1898358;,2R01GM062939,04/01/2001,11/30/2013,"1-acyl-sn-glycerol-3-phosphate; 1-oleoyl-lysophosphatidic acid; APC; APC Protein; Abnormal Cell; Actins; Address; Adenomatous Polyposis Coli Protein; Adhesions; Assay; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Blood Serum; COX7A-Related Protein; COX7A2L; COX7A2L Protein; COX7AR Protein; COX7RP Protein; Cell Body; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Polarity; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Centrosome; Characteristics; Cues; Cytochrome C Oxidase Subunit VIIA Polypeptide 2 Like Protein; Cytokinesis; Cytoplasmic Division; Cytoskeletal System; Cytoskeleton; DNA Sequence Rearrangement; Development; Disease; Disorder; EB1 Protein; Elements; Eukaryote; Eukaryotic Cell; Event; Family; Fibroblasts; GFAC; GTP Phosphohydrolases; GTPases; Generations; Genetic; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; INFLM; Image; Immune response; In Vitro; Inflammation; Intracellular Communication and Signaling; Kinesin; Knowledge; LPA; Lead; Length; Life; Lysophosphatidic Acids; Lysophospholipids; MOPA; Mammals, Mice; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Micro-tubule; Microtubule Stabilization; Microtubules; Mitochondrial Cytochrome C Oxidase Subunit VIIA-Related Protein; Model System; Models, Biologic; Molecular; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Motility; Motility, Cellular; Motor; Murine; Mus; Neoplasm Metastasis; Nucleus; Ortholog; Orthologous Gene; Pathway interactions; Pb element; Phenotype; Polymers; Position; Positioning Attribute; Process; Proteins; Rearrangement; Regulation; Role; Secondary Neoplasm; Secondary Tumor; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small G-Proteins; Small GTPases; Specificity; Subcellular Process; System; System, LOINC Axis 4; Testing; Tumor Cell Migration; Work; Wound Healing; Wound Repair; Xenopus; biological signal transduction; cancer metastasis; cell associated matrix; cell body (neuron); cell cortex; cell motility; cell transduction; cellular polarity; cellular transduction; combat; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; host response; imaging; immunoresponse; in vivo; intracellular skeleton; lysophosphatidic acid; migration; monolayer; monooleylphosphatidate; monooleylphosphatidic acid; mutant; neural cell body; neuronal cell body; new therapeutic target; novel; pathway; polymerization; public health relevance; research study; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; single molecule; social role; soma; tissue repair; transduced cells; wound",REGULATION OF MICROTUBULES BY RHO GTPASES," Microtubules are dynamic cytoskeletal elements that contribute to cellular responses to external cues, such as growth factor stimulation. In migrating cells, microtubules contribute to the polarization of cellular activities that allow the cell to migrate in a directional fashion but the molecular mechanisms involved are unclear. Understanding the molecular mechanism controlling microtubules in migrating cells will contribute to fundamental knowledge of how cells migrate during development, wound healing and immune response and may lead to the identification of novel therapeutic targets for combating diseases involving abnormal cell migration, such as cancer metastasis and inflammation.",62939,ZRG1,Special Emphasis Panel,,9,488377,
7783485,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM069027-05A1,,NIGMS:323000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAINT LOUIS,UNITED STATES,ANESTHESIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"GAUTAM, NARASIMHAN ;",1874013;,2R01GM069027,04/01/2004,01/31/2014,"A549; Address; Biological Models; Body Tissues; Bradykinin Receptor; Cancerous; Cancers; Carcinoma; Carcinoma Cell; Cathepsins; Cell Aging; Cell Communication and Signaling; Cell Senescence; Cell Signaling; Cell division; Cell membrane; Cells; Cellular Aging; Cellular Stress; Chemotherapy-Hormones/Steroids; Complex; Cues; Cytoplasmic Membrane; Diabetes Mellitus; Disease; Disorder; Endocrine Gland Secretion; Endoplasmic Reticulum; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Ergastoplasm; Esteroproteases; Event; Family; Fibroblasts; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gastrointestinal Tract, Pancreas; Generalized Growth; Golgi; Golgi Apparatus; Golgi Complex; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Hormones; Humulin R; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Life; Lung; M3 receptor; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Model System; Models, Biologic; Molecular; Muscarinic Acetylcholine Receptor; Muscarinic M3 Receptor; Neoplasm Metastasis; Novolin R; PKD protein; Pancreas; Pancreatic; Peptidases; Peptide Hydrolases; Physiologic; Physiological; Plasma Membrane; Play; Process; Proteases; Protein Subunits; Proteinases; Proteolytic Enzymes; Receptor Activation; Receptor Protein; Receptor, Muscarinic M3; Receptors, Muscarinic; Regulation; Respiratory System, Lung; Role; Secondary Neoplasm; Secondary Tumor; Secretory Granules; Secretory Vesicles; Senescence, Cellular; Senescence, Replicative; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic Hormone; Therapeutic Intervention; Tissue Growth; Tissues; Tumor Cell; Tumor Cell Migration; age effect; aging effect; base; biological signal transduction; cancer metastasis; cytokine; design; designing; diabetes; disease/disorder; epithelial carcinoma; extracellular; insulin secretion; intervention therapy; lung Carcinoma; malignancy; neoplasm/cancer; neoplastic cell; new therapeutic target; novel; ontogeny; plasmalemma; prevent; preventing; protein complex; protein kinase D; public health relevance; pulmonary; receptor; senescence; sensor; social role; tumor; tumor growth",SIGNALING IN LIVING CELLS," Project Narrative The altered secretion of molecules plays an important role in disease -- cathepsin D in cancer and insulin in diabetes. Cellular senescence is thought to be cancer protective by stopping cell division but the increased secretion of molecules from these cells is thought to encourage tumor formation in surrounding tissue. We propose to identify mechanisms that regulate secretion of these molecules and cellular senescence. Identifying the mechanisms can provide new targets for therapeutic approaches to address cancer, diabetes and the deleterious effects of ageing.",69027,MIST,Molecular and Integrative Signal Transduction Study Section,A1,5,323000,
7737625,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM070559-06,,NIGMS:208500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LEXINGTON,UNITED STATES,ZOOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"PALLI, SUBBA R;",7360008;,2R01GM070559,02/01/2005,01/31/2014,"2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (E,E)-; 20-Hydroxyecdysone; 21+ years old; 2PP2A; Adult; Affinity; Agonist; Anabolism; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Beta-Ecdysone; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Metamorphosis; Biological Models; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Chemotherapy-Hormones/Steroids; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2beta,3beta,5beta,22R)-; Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-, (2beta,3beta,5beta,22R)-; Code; Coding System; Crustecdysone; Culicidae; Data; Development; Disease; Disease Vectors; Disorder; Ecdysis; Ecdysone; Ecdysteroids; Ecdysterone; Electrophoretic Mobility Shift Assay; Embryo Development; Embryogenesis; Embryonic Development; Endocrine Gland Secretion; Event; Extracellular Space; Farm Animal; Fat Body; Female; Flour; Food; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; GeneHomolog; Genes; Genes, Switch; Genetic Intervention; Genital System, Female, Ovary; Genome; Genomics; Goals; Grant; HLA-DR Associated Protein II; Homolog; Homologous Gene; Homologue; Hormone Receptor; Hormones; Human; Human, Adult; Human, General; I2PP2A; IGAAD; Inhibitor of GZMA-Activated DNase; Insect Control; Insect Growth Regulators; Insecta; Insects; Intercellular Space; Intervention, Genetic; Intracellular Communication and Signaling; Invertebrates, Insects; Juvenile Hormones; Label; Life Cycle; Life Cycle Stages; Ligand Binding; Livestock; Livestocks; Man (Taxonomy); Man, Modern; Medicine; Membrane; Messenger RNA; Metamorphosis, Biological; Methods; Methoprene; Mobility Shift Assay; Model System; Models, Biologic; Molecular; Molecular Analysis; Molecular Biology, Gene Therapy; Molting; Molting Hormone; Mosquito Control; Mosquitoes; Oocytes; Oogenesis; Ovary; Ovocytes; PHAPII; Phosphatase 2A Inhibitor I2PP2A; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Production; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Binding; Protein Precursors; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Receptor Protein; Regulation; Reproduction; Resistance development; Resistant development; Role; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Science of Medicine; Screening procedure; Sensory; Sequence-Specific Posttranscriptional Gene Silencing; Set protein; Signal Transduction; Signal Transduction Systems; Signaling; Switch Genes; System; System, LOINC Axis 4; TAF-IBETA; Template Activating Factor I Beta; Therapeutic Hormone; Therapy, DNA; Time; Tissue Engineering; Tribolium; Tribolium (beetle); Vector (Infectious Agent); Vertebrate Animals; Vertebrates; Vitellogenesis; Vitellogenins; adult human (21+); analog; base; biological signal transduction; biosynthesis; developing resistance; disease/disorder; egg; engineered tissue; experiment; experimental research; experimental study; follicular epithelial cell; gel shift assay; gene product; gene therapy; genetic promoter element; genetic therapy; genome sequencing; hormonal regulation; hormone analog; hormone biosynthesis; hormone regulation; in vitro Assay; in vivo; insect disease; knock-down; life course; mRNA; meetings; membrane structure; metamorphosis; non-genomic; nongenomic; prevent; preventing; protein complex; public health relevance; receptor; reproductive; research study; response; screening; screenings; social role; therapeutic protein; transcription factor; uptake; vector control; vertebrata",Molecular analysis of juvenile hormone action," PROJECT NARRATIVE Insect juvenile hormone analogs are being used for mosquito control, but some mosquitoes are already developing resistance to these analogs. The results from these studies will aid in understanding the mode of action of JH analogs, thus facilitating their judicious use. The genes identified will be useful to develop screening assays to identify new insect disease vector control agents and for developing gene switches useful for various applications such as gene therapy, tissue engineering and therapeutic protein production.",70559,VB,Vector Biology Study Section,,6,208500,
7714616,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM072611-05,,NIGMS:266820;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRINCETON,UNITED STATES,MISCELLANEOUS,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"FAN, JIANQING ;",8068933;,2R01GM072611,02/01/2006,01/31/2014,"Address; Bio-Informatics; Bioinformatics; Cancer Causing Agents; Cancer of Breast; Cancers; Carcinogens; Cells; Classification; Clinical; Cluster Analyses; Cluster Analysis; Computer Programs; Computer software; Cox Proportional Hazards Models; Data; Data Set; Dataset; Development; Drugs; Gene Proteins; Genes; Glycosylation-Inhibiting Factor; Harvest; Hereditary; Human; Human, General; Inherited; Investigation; Linear Models; Liver; Lung Neoplasms; Macrophage Migration Inhibitory Factor; Macrophage Migration-Inhibitory Factors; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Migration Inhibition Factor; Migration Inhibition Factors, Macrophage; Migration Inhibitory Factor; Modeling; Molecular; Multiple Myeloma; Myeloma, Plasma-Cell; Necrosis; Necrotic; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Oncogens; Outcome; Pharmaceutic Preparations; Pharmaceutical Preparations; Protein Gene Products; Proteins; Proteomics; Pulmonary Neoplasms; Quality Control; Regression Analyses; Regression Analysis; Regression Diagnostics; Research; Sampling; Screening procedure; Software; Statistical Methods; Statistical Regression; Survival Analyses; Survival Analysis; Systematics; Techniques; Theoretical Studies; Therapeutic; Time; Toxicogenomics; Tumor of the Lung; anticancer research; arylpyruvate keto-enol tautomerase; body system, hepatic; cancer research; computer program/software; drug/agent; gene interaction; gene product; high throughput analysis; innovative technologies; malignancy; malignant breast neoplasm; member; myeloma; myelomatosis; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, hepatic; p-hydroxyphenylpyruvate tautomerase; phenylpyruvate tautomerase; protein expression; public health relevance; screening; screenings; simulation; theories; therapeutic target; tool",Statistical Methods for Ultrahigh-dimensional Biomedical Data," Statistical Methods for Ultrahigh-dimensional Biomedical Data PI: Jianqing Fan Project Narrative (Part 7)  This proposal develops novel statistical and bioinformatic tools for finding genes and proteins that are associated with clinical outcomes. Data sets from on-going biomedical studies on cancer such as breast cancer, multiple myeloma, neuroblastoma, lung tumor, and liver carcinogen will be critically analyzed using the newly developed statistical and bioinformatic tools. The research findings will have strong impact on understanding molecular mechanisms of cancer and developing therapeutic targets.",72611,BMRD,Biostatistical Methods and Research Design Study Section,,5,266820,
7785239,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM074150-05,,NIGMS:353470;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,627922248,US,CA,920930660,LUDWIG INSTITUTE FOR CANCER RESEARCH,"CLEVELAND, DON W.;",8010271;,2R01GM074150,02/01/2006,01/31/2014,"Affinity; Aneuploid; Aneuploidy; Anti-Oncogenes; Antioncogenes; CENP-A; Cancer Cause; Cancer Etiology; Cannot achieve a pregnancy; Cations; Cell Cycle; Cell Division Cycle; Cell division; Cells; Centromere; Chaperone; Characteristics; Chromatin; Chromosomal Loss; Chromosome Segregation; Chromosomes; Chromosomes, Artificial, Yeast; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Sequence; Deoxyribonucleic Acid; Difficulty conceiving; Emerogenes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; FLR; Failure (biologic function); Fluorescence; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth; Hereditary; Histone H3; Histones; Human; Human, General; Individual; Infertility; Inherited; Lead; Malignant; Malignant - descriptor; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Medical; Methods; Modification; Molecular Chaperones; Muscle Rigidity; Mutation; Nucleosomes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Pathway interactions; Pb element; Physiologic pulse; Property; Property, LOINC Axis 2; Pulse; Recruitment Activity; Research; Rigidity; Rigidity, Muscular; Role; Site; System; System, LOINC Axis 4; Time; Tissue Growth; Tumor Suppressing Genes; Tumor Suppressor Genes; Unscheduled DNA Synthesis; Variant; Variation; YAC Vector; centromere autoantigens 17K; centromere protein 17K; centromere protein A; chromatin remodeling; daughter cell; failure; genetic element; genome mutation; heavy metal Pb; heavy metal lead; in vivo; infertile; oncosuppressor gene; ontogeny; pathway; public health relevance; recruit; repair; repaired; social role; tandem mass spectrometry; tumor; unable to bear children",Mammalian Centromere Assembly," PROJECT NARRATIVE Understanding how centromeres function and the genetic mechanisms that may generate failure of normal chromosome delivery have broad medical implications. Among these, errors of chromosome segregation lead to infertility. Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.",74150,MGB,Molecular Genetics B Study Section,,5,353470,
7810490,R01,GM,2,,02/01/2010,01/31/2011,PA-07-070,2R01GM076242-05,,NIGMS:308016;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SALT LAKE CITY,UNITED STATES,BIOCHEMISTRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"HILL, CHRISTOPHER P.;",1864542;,2R01GM076242,02/01/2006,01/31/2014,"3-D structure; 3-dimensional structure; 3D structure; ATP phosphohydrolase; ATPase; ATPase Domain; Abscission; Acetylation; Adenosine Triphosphatase; Adenosinetriphosphatase; Affinity; Assay; Bacteria; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biochemical Genetics; Biochemistry; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; C-terminal; Casein Kinase TS; Casein Kinase-2; Chemistry, Biological; Chromatin; Collaborations; Complex; Crystallization; Crystallographies; Crystallography; DNA; DNA Binding; DNA Binding Interaction; DNA Helicases; DNA Polymerase II; DNA Polymerase epsilon; DNA Polymerases; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA replication factor A; DNA unwinding enzyme; DNA, Single-Stranded; DNA-Dependent DNA Polymerase II; DNA-Dependent DNA Polymerases; DNA-Dependent RNA Polymerase II; DNA-Directed DNA Polymerase; Data; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Dependence; Deposit; Deposition; Dissociation; EC 2.7.7.7; Electron Microscopy; Event; Excision; Extirpation; Formosa; Foundations; Gene Expression; Gene Products, RNA; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic analyses; Genetic defect; Genetic, Biochemical; Goals; Growth; Histone H2A; Histones; Human; Human, General; In Vitro; Individual; L-Tyrosine; Ligand Binding Protein; Ligands; Light; Link; Man (Taxonomy); Man, Modern; Maps; Mediating; Methods; Modeling; Molecular; Molecular Interaction; Mutation; N Domain; N-terminal; NH2-terminal; Nucleic Acid Binding; Nucleosomes; Pathway interactions; Peptides; Phase; Phosphorylated Peptide; Photoradiation; Pol II; Polymerase; Process; Productivity; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Kinase CK2; Protein Kinase CKII; Protein Subunits; Proteins; Publishing; RNA; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA, Non-Polyadenylated; Regulation; Removal; Replication Origin; Reporting; Republic of China; Resolution; Ribonucleic Acid; Risk; Role; SH2 Domains; Single-Stranded DNA; Structure; Surgical Removal; TYR; Taiwan; Testing; Time; Tissue Growth; Transcription; Transcription Elongation; Transcription Initiation; Transcription Process; Transcription, Genetic; Translating; Translatings; Tyrosine; Tyrosine, L-isomer; Yeasts; base; casein kinase II; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; helicase; high reward; in vivo; interest; language translation; novel; ontogeny; ori Region; para-Tyrosine; pathway; prevent; preventing; protein complex; public health relevance; replication factor A; replication protein A; research study; resection; residence; single-strand binding protein RP-A; social role; src Homology Region 2 Domain; three dimensional structure; yeast genetics",Nucleosome Reorganizing/Remodeling Complexes," PROJECT NARRATIVE The proteins/complexes Spt6, yFACT, and RSC mediate nucleosome dynamics and other events that regulate gene expression and DNA replication. We aim to advance understanding of function by a combination of determining relevant three-dimensional structures, biochemistry, and genetic analysis.",76242,ZRG1,Special Emphasis Panel,,5,308016,
7782012,R01,HD,2,,01/20/2010,11/30/2010,PA-07-070,2R01HD037466-10A1,,NICHD:301697;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,MADISON,UNITED STATES,PSYCHOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SAFFRAN, JENNY ;",2112199;,2R01HD037466,08/01/2000,11/30/2014,"0-11 years old; Address; Affect; Auditory Prosthesis; Beuren syndrome; Cerebral Palsy; Child; Child Youth; Children (0-21); Cochlear Implants; Cochlear Prosthesis; Cognitive Discrimination; Contiguous Gene Syndrome, Williams; Deaf; Development; Discrimination; Discrimination (Psychology); Elfin Facies Syndrome; Environment; Face; Fanconi Schlesinger syndrome; Fanconi-Schlesinger syndrome; Future; Glean; Hard of Hearing Persons; Hearing Impaired Persons; Human Development; Human, Child; Illinois; Individual; Infant; Investigation; Knowledge; Knowledge of Results; Knowledge of Results (Psychology); Language; Language Development; Language Development Disorders; Language Disorders; Language Disorders, Developmental; Language disability; Learning; Learning, Machine; Life; Linguistic; Linguistics; Link; Literature; Machine Learning; Maps; Measures; Method LOINC Axis 6; Methodology; Methods; Outcome; Outcome Study; Pattern; Persons With Hearing Impairments; Phase; Population; Poverty; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Public Health; Research; Risk; Role; Science of Statistics; Sound; Sound - physical agent; Special Population; Speech; Speech or Language, Developmental Disorder; Statistics; Structure; Study, Outcome; Sum; Surface; Testing; Time; Toddler; Universities; Washington; Williams Barratt syndrome; Williams Syndrome; Williams syndrome (WMS, WS); Williams-Barratt syndrome; Williams-Beuren Syndrome; Williams-Beuren syndrome (WBS); Work; acquiring language skills; base; children; elfin-facies hypercalcemia syndrome; expectation; experience; experiment; experimental research; experimental study; facial; hypercalcemia-peculiar facies-supravalvular aortic stenosis syndrome; hypercalcemia/Williams-Beuren syndrome; idiopathic hypercalcemia-supravalvular aortic stenosis syndrome; innovate; innovation; innovative; kernel methods; knowledge of results; language acquisition; language deficit; language learning; language processing; mental retardation-typical facies-aortic stenosis syndrome; named group; natural language; programs; public health medicine (field); public health relevance; research study; social role; sound; specific language impairment; statistical learning; statistics; success; support vector machine; theories; youngster",Statistical Learning in Language Acquisition," PROJECT NARRATIVE These studies, which are focused on typical language development, provide an opportunity to test targeted hypotheses concerning the mechanisms underlying positive language acquisition outcomes. The results will inform subsequent studies of children at risk for atypical language development, a major public health concern. We are currently working with a number of relevant populations who are potential targets of future studies based on the experiments proposed in this application, including children with Specific Language Impairment (with Dr. Julia Evans, San Diego State University), deaf toddlers who use cochlear implants (with Dr. Ruth Litovsky, UW-Madison and Dr. Tina Grieco-Calub, Northern Illinois University), toddlers who are late-talkers (with Dr. Susan Ellis-Weismer, UW-Madison), children living in poverty (with Drs. Jan Edwards and Julie Washington, UW-Madison), toddlers with Williams Syndrome (with Drs. Carolyn Mervis and Cara Cashon, U. of Lousiville), and children with Cerebral Palsy (with Dr. Katie Hustad, UW-Madison).",37466,LCOM,Language and Communication Study Section,A1,10,301697,
7785144,R01,HD,2,,01/13/2010,11/30/2010,PA-07-070,2R01HD037933-11,,NICHD:328888;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,DALLAS,UNITED STATES,BIOCHEMISTRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"LIN, RUEYLING ;",3135336;,2R01HD037933,01/13/2010,11/30/2014,"Affect; Affinity; Amino Acids; Animals; Anterior; Binding; Binding (Molecular Function); Biochemical; Blastocytes; Blastomere; C elegans; C-terminal; C.elegans; Caenorhabditis elegans; Cancer Cause; Cancer Etiology; Cancers; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell division; Cells; Cessation of life; Colorectal Cancer; Complex; Daughter; Death; Defect; Development; Diagnosis; Differential Gene Expression; EC 2.7; EC 2.7.2-; ERK 2; Embryo; Embryo Development; Embryo stage 2; Embryogenesis; Embryonic; Embryonic Development; Endoderm; Exhibits; Export, Nuclear; Extracellular Signal-Regulated Kinase 2; Extracellular Signal-Regulated Kinases; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Intracellular Communication and Signaling; Kinases; Laboratories; Lead; Link; MAP Kinase 1; MAP Kinase 2; MAP Kinase Activation Pathway; MAP Kinase Signaling Pathways; MAP kinase; MAPK; MAPK1; MAPK1 Mitogen-Activated Protein Kinase; MAPK2 Mitogen-Activated Protein Kinase; Malignant Neoplasms; Malignant Tumor; Mesoderm; Mitogen Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 2; Mitogen-Activated Protein Kinases; Mitotic spindle; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutation; Nuclear; Nuclear Export; Nucleus; P42MAPK; PRKM1; Pathway interactions; Pb element; Phosphorylation; Phosphorylation Site; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Phosphorylation; Public Health; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Role; Role of beta-arrestins in the activation and targeting of MAP kinases; Rotation; SIS; Scaffolding Protein; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sister; Site; Specific qualifier value; Specified; Staging; Structure of embryo stage 2; Testing; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Transcription; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Translating; Translatings; Transphosphorylases; Up-Regulation; aminoacid; biological signal transduction; cancer type; conformation; conformational state; embryo stage 2; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; language translation; malignancy; neoplasm/cancer; p42 MAP Kinase; p42 MAPK; p42(Mapk) Kinase; p42(Mitogen-Activated Protein Kinase); pathway; public health medicine (field); public health relevance; research study; social role",Transcriptional Regulation by the Wnt Effector POP-1," Project Narrative: Relevance to public health: Colorectal cancer causes more than 50,000 deaths annually in the US, and greater than 90% of these cancers are caused by activating mutations in the Wnt signaling pathway. Our ability to detect, diagnose and treat these cancers (as well as other cancer types and embryological defects caused by deregulated Wnt signaling) will rely heavily upon our understanding of this pathway, its components and their normal regulation. This proposal aims to significantly broaden our understanding of the Wnt signaling pathway, and how it intersects with other signaling pathways during development.",37933,DEV2,Development - 2 Study Section,,11,328888,
7779938,R01,HD,2,,02/01/2010,01/31/2011,PA-07-070,2R01HD047283-06,,NICHD:612474;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,MINNEAPOLIS,UNITED STATES,MISCELLANEOUS,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MCCAA, ROBERT EDWARD;",3055092;,2R01HD047283,09/01/2004,01/31/2015,"Address; Agreement; Archives; Area; Asia; Behavioral Sciences; Censuses; Characteristics; Child Mortality; Code; Coding System; Collection; Communities; Confidentiality; Consensual Unions; Core Facility; Country; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Designing computer software; Development; Development, Economic; Development, Economical; Documentation; Economic Development; Economics; Education; Educational aspects; Electronics; Europe; European; Family; Fecundability; Fecundity; Fertility; Floor; Foundations; Funding; Future Generations; Generations, Future; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; Grant; Health; History; Household and Family; Housing; IT Systems; Information Systems; Information Technology Systems; Infrastructure; International; Investigators; Investments; Knowledge; Latin America; Marital Status; MeSH Descriptors Class 4; Metadata; Mission; Mortality Decline; NICHD; NIH; National Institute of Child Health and Human Development; National Institutes of Health; National Institutes of Health (U.S.); Nature; On-Line Systems; Online Systems; Persons; Phase; Pilot Projects; Policies; Policy Making; Population; Population Database; Population Dynamics; Procedures; Process; Protocol; Protocols documentation; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Researchers; Risk; SCHED; Sampling; Schedule; Science; Scientist; Series; Services; Sewage; Social Sciences; Software Design; System; System, LOINC Axis 4; Systems, Data; Time; Unions, Consensual; United States National Institutes of Health; Water Supply; Work; aging population; clinical data repository; clinical data warehouse; computerized data processing; cost; data processing; data repository; disability; geographic site; health economics; human population dynamics; improved; literacy; migration; online computer; pilot study; population health; privacy of information; public health relevance; relational database; residence; signal processing; social; tool; web based",Integrated Samples of Eurasian Censuses," Project Narrative The proposed database is directly relevant to the central mission of the National Institutes of Health; by adding dozens of new Eurasian census samples to a global, integrated database of census microdata, this infrastructure will advance fundamental knowledge about the nature of human population dynamics and will spark new health-related research. The data series will result in a substantial body of new scientific and policy- relevant health-related research on key priority areas of the Demographic and Behavioral Sciences Branch of NICHD, including family change, population health, and migration. By opening access to a vast collection of microdata, including material from the 2010 census round, the project will allow social science and health researchers to address fundamental questions about the impact of the extraordinary social and economic transformations that have reshaped the Eurasian continent during the past half century.",47283,SSPS,Social Sciences and Population Studies Study Section,,6,612474,
7785622,R01,HL,2,,01/15/2010,12/31/2010,PA-07-070,2R01HL016152-34A2,,NHLBI:335100;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,ANATOMY/CELL BIOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"MORAD, MARTIN ;",1880647;,2R01HL016152,09/01/1978,12/31/2014,"1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 2,2,6,6-tetramethyl-4-piperidinol-N-oxyl; 21+ years old; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine; 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical; 4-hydroxy-TEMPO; ATP phosphohydrolase; ATPase; Abbreviations; Acidosis; Acidosis, Lactic; Active Oxygen; Adenosine Triphosphatase; Adenosinetriphosphatase; Adult; Apoptosis; Apoptosis Pathway; Atrial; Auricle of Heart; CCCP; Ca Release Channel-Ryanodine Receptor; Caffeine; Calcium-Ryanodine Receptor Complex; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carbonyl Cyanide meta-Chlorophenyl Hydrazone; Cardiac; Cardiac Atrium; Cardiac Myocytes; Cardiocyte; Cardiomyopathies; Caveolin Proteins; Caveolins; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Characteristics; Chiro-Inositol; Coloring Agents; Common Rat Strains; Confocal Microscopy; Dependence; Development; Dialysis; Dialysis procedure; Dihydropyridine Receptors; Disorder of muscle, unspecified; Dyes; Dystrophin; Electrophysiology; Electrophysiology (science); Embryo; Embryonic; Encephalomyelitis, Subacute Necrotizing; Encephalomyelopathy, Subacute Necrotizing; Encephalopathy, Subacute Necrotizing; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Energy Supply; Extracellular Matrix, Integrins; Family Felidae; Felidae; Felids; Fluorescence; Football; Generations; HOTMP; Hand; Heart; Heart Atrium; Heart myocyte; Human; Human, Adult; Human, General; HyTEMPO; Hypoxia; Hypoxic; IP3R; IP3R1; ITPR1; ITPR1 gene; Image; Individual; Inositol; Insp3r1; Integrins; Intracellular Communication and Signaling; Ischemia-Reperfusion Injury; Isoprenaline; Isopropyl Noradrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isuprel; Kinetic; Kinetics; L-Type VDCC alpha-1 Subunit; Lactic Acidosis; Leigh Disease; Leigh Syndrome; Length; Liquid substance; Location; MMC; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Manufactured football; Mechanics; Mediating; Membrane Potentials; Mesoinositol; Metabolic; Methods and Techniques; Methods, Other; Mice; Microscopy, Confocal; Mitochondria; Mitochondrial Porin; Molecular; Monitor; Mononitrogen Monoxide; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscle, Cardiac; Muscle, Heart; Muscular Diseases; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes; Myocytes, Cardiac; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nature; Neonatal; Neurophysiology / Electrophysiology; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear; Oxygen Deficiency; Oxygen Radicals; Pathology; Peripheral; Physiologic pulse; Play; Pressure; Pressure- physical agent; Pro-Oxidants; Process; Production; Propanedinitrile, ((3-chlorophenyl)hydrazono)-; Proteins; Pulse; RU360; Rat; Rattus; Reactive Oxygen Species; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Ryanodine; Reducing Agents; Reductants; Reperfusion Damage; Reperfusion Injury; Research; Resolution; Resting Potentials; Role; Ru 360; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Sarcolemma; Sarcoplasmic Reticulum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Source; Spatial Distribution; Staining method; Stainings; Stains; Stimulus; Stress; Stretching; Structural Protein; Supply, Energy; TMPN; TPL cpd; Techniques; Testing; Time; Transmembrane Potentials; VDAC mitochondrial porin; VDAC proteins; Ventricular; Voltage-Dependent Anion Channel; Work; Work Load; Workload; Xanthylium, 9-(4-(bis(carboxymethyl)amino)-3-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)phenyl)-3,6-bis(dimethylamino)-, chloride; adult human (21+); atrium; base; biological signal transduction; cardiac muscle; cardiomyocyte; cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; dialysis therapy; endothelial cell derived relaxing factor; extracellular; feline; fluid; fluorescence imaging; gene product; heart muscle; imaging; improved; infancy; infantile; inhibitor; inhibitor/antagonist; liquid; meetings; mitochondrial; mitochondrial megachannel; mitochondrial membrane; mitochondrial permeability transition pore; mitochondrial pore protein; muscular disorder; myocardium disorder; nitroxyl 2; novel; pore forming protein VDAC; porins, mitochondria; postnatal; pressure; public health relevance; receptor; response; rhod 2 fluorescent dye; rhod 2-AM; rhod-2; sensor; social role; tanol; tempol; triphosphate; tripolyphosphate; voltage clamp; voltage-dependent, anion-selective channels; voltage-dependent, anion-selective, channel forming protein, mitochondrial",Electrophysiology of Neonatal and Adult Heart," Human heart has great energetic needs because of its large workload (equivalent to pushing 1 ton the length of a football field per day); where the required energy supply is provided by mitochondria occupying ~30% of the cellular volume. Since cardiac contractility in normal and abnormal heart is mediated by cycling of Ca2+ in the cell, it is likely that Ca2+ signaling in the heart may also be the mechanism by which energy supply from the mitochondria is regulated. The nature of the signals that transmit information between the generation of energy supply per beat from the mitochondria and the Ca2+ released from the SR to meet the contractile needs of the myocyte is the subject of the proposed research in both healthy and diseased hearts.",16152,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",A2,34,335100,
7778447,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL031607-26A1,,NHLBI:406250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"COHEN, RICHARD A;",1880469;,2R01HL031607,09/30/1983,01/31/2014,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)-; ATP phosphohydrolase (Ca(2+)-transporting); ATP-protein phosphotransferase; ATP2A2; Abbreviations; Acetamide, 2-iodo-; Active Oxygen; Adenosine Triphosphatase, Calcium; Affect; Antibodies; Aorta; Arterial Injury; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Biotin; Blood (Leukemia); Blood Coagulation Factor IV; Blood Vessels; Body Tissues; Bovine Species; Ca(2+)-Transporting ATPase; Ca++ element; Ca2+ ATPase; Ca2+ transporting ATPase; Calcium; Calcium ATPase; Calcium Adenosinetriphosphatase; Calcium Pump; Cattle; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cleland's Reagent; Coagulation Factor IV; Common Rat Strains; Cyclic GMP-Dependent Protein Kinases; Cysteine; D-Glucose; DNA Synthesis Factor; Data; Development; Dextrose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Disease; Disorder; Dithiothreitol; Down-Regulation; Down-Regulation (Physiology); Downregulation; ECGF; Endogenous Nitrate Vasodilator; Endoplasmic Reticulum; Endothelial Cell Growth Factor; Endothelial Cells; Endothelium; Endothelium-Derived Relaxing Factor; Ergastoplasm; Erythrocuprein; Erythroid; FGF; Factor IV; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Funding; Generalized Growth; Glucose; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Grant; Growth; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; HBGF; Half-Cystine; Hemocuprein; Heterozygote; Hindlimb; Human; Human, General; Hyperlipemia; Hyperlipidemia; Injury; Insulin Resistance; Iodoacetamide; Ischemia; Isotopically-Coded Affinity Tagging; Knock-in; Knock-in Mouse; L-Cysteine; Label; Leiomyocyte; Lesion; Leukemias, General; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mercaptans; Mercapto Compounds; Methods; Mice; Modeling; Mononitrogen Monoxide; Motility; Motility, Cellular; Murine; Mus; Myocytes, Smooth Muscle; N element; N2 element; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Obesity; Oncogene SKI; Oxidants; Oxidation-Reduction; Oxidizing Agents; Oxygen; Oxygen Radicals; PKG; Pathogenesis; Peroxonitrite; Peroxonitrites; Peroxynitrites; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Pro-Oxidants; Process; Protein Kinase; Protein Kinase G; Proteins; Rat; Rattus; Reactive Nitrogen Species; Reactive Oxygen Species; Redox; Regulation; Relaxation; Rodent; Rodentia; Rodentias; Role; SERCA2; SKI; SKI gene; SOD; Sarcoplasmic Reticulum; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; Sulfhydryl Compounds; Superoxide Anion; Superoxide Dismutase; Superoxide Radical; Superoxide[{..}]superoxide oxidoreductase; Superoxides; Tagging, Isotope-Coded Affinity; Thapsigargin; Thiols; Tissue Growth; Tissues; Transfection; Up-Regulation; Up-Regulation (Physiology); Upregulation; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell; Vascular Endothelial Growth Factors; Vasodilatation; Vasodilation; Vasorelaxation; Vegf; Vitamin H; Work; adduct; adiposity; angiogenesis; atherogenesis; atheromatosis; atherosclerotic vascular disease; blood vessel disorder; bovid; bovine; cGMP kinase; cGMP-Dependent Protein Kinases; calcium transporting ATPase; cell motility; coenzyme R; corpulence; corpulency; corpulentia; cow; cytocuprein; diabetes; disease/disorder; electron acceptor; endothelial cell derived relaxing factor; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; glutaredoxin; glycogen synthase a kinase; hydroxyalkyl protein kinase; improved; in vivo; insulin resistant; leukemia; microvascular complications; microvascular complications of diabetes; microvascular disease; migration; mouse model; mutant; obese; obese people; obese person; obese population; ontogeny; oxidation; oxidation reduction reaction; peroxynitrite; phospholamban; phosphorylase b kinase kinase; prevent; preventing; public health relevance; response; social role; sulfhydryl group; tool; type I and type II diabetes; uptake; v-SKI Avian Sarcoma Viral Oncogene Homolog; vascular",Redox Regulation of SERCA by Nitric Oxide," Vascular disease, particularly that caused by diabetes mellitus, is initiated and promoted by the impaired ability of nitric oxide (¨NO) released by endothelial cells to regulate vascular contraction, migration, and proliferation. The studies funded by this proposal have identified the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) to be stimulated by ¨NO via its ability to introduce glutathione SERCA adducts, thereby lowering intracellular Ca2+ concentrations and regulating cell function. Our proposed studies intend to demonstrate the role for this mechanism in vivo using mouse models of diabetic vascular disease, including a mouse that expresses a mutant SERCA that lacks the key thiol.",31607,VCMB,Vascular Cell and Molecular Biology Study Section,A1,26,406250,
7782307,R01,HL,2,,02/01/2010,12/31/2010,PA-07-070,2R01HL049879-12A1,,NHLBI:288750;OD:92500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBUS,UNITED STATES,NUTRITION,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"HARRISON, EARL HOWARD;",1867656;,2R01HL049879,07/01/1994,12/31/2013,"(3R,3'R)-beta,beta- carotene-3,3'-diol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; 9-cis-Retinoic Acid Receptor; AHR; Acids; Address; Aldehydes; All-Trans-Retinol; Analytical Chemistry; Animals; Anti-Infective vitamin; Antixerophthalmic vitamin; Aryl Hydrocarbon Receptor; Axerophthol; Axerophtholum; Beta Carotene; Betacarotene; Biological; Biological Function; Biological Process; Biosterol; Blood Plasma; Blood monocyte; Body Tissues; C element; Cancer of Prostate; Cancers; Carbon; Cardiovascular Diseases; Carotene; Carotenes and Carotenoids; Carotenoids; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular Retinol Binding Protein; Characteristics; Chemicals; Chemistry, Analytic; Chemistry, Analytical; Color; Consumption; Cultured Cells; Development; Diet; Dietary Carotenoid; E2A; E2A Immunoglobulin Enhancer Binding Factor E12; E2A Immunoglobulin Enhancer Binding Factor E47; Enzymatic Biochemistry; Enzyme Kinetics; Enzymes; Enzymology; Fatty Liver; Food; Gene Expression; Generalized Growth; Genes; Growth; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human, General; ITF1; Immunoglobulin Transcription Factor 1; In Vitro; Intermediary Metabolism; Juice; Kappa-E2-Binding Factor; Knock-out; Knockout; Knockout Mice; Knowledge; LNCaP; LUT; Lard-Factor; Lead; Leutin; Ligands; Liver; Liver Cells; Liver Steatosis; Lutein; Lyc-O-Mato; METBL; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Metabolic; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Knock-out; Mice, Knockout; Micronutrients; Molecular; Murine; Mus; Nuclear; Nuclear Translocator; Null Mouse; Nutritional; Oleovitamin A; Ophthalamin; Oxygenases; PPAR; Parents; Pathway interactions; Pb element; Peroxisome Proliferator-Activated Receptors; Phenotype; Pigments; Plasma; Play; Prostate CA; Prostate Cancer; Prostatic Cancer; RXR; RXR Protein; Receptor Protein; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Recombinants; Research; Reticuloendothelial System, Serum, Plasma; Retinoic Acid Receptor; Retinoic Acid Receptor RXR; Retinoid X Receptors; Risk; Roche Brand of Betacarotene; Role; SXR; SXR receptor; Serum, Plasma; Solatene; Substrate Specificity; TCDD Receptors; TCF3; Testing; Tissue Growth; Tissues; Tomatoes; Transcription Factor 3; Transcription Factor E2-Alpha; Triglyceride Metabolism; U937 Cells; Urinary System, Urine; Urine; Vitamin A; Vitamin A Alcohol; Vitamin A USP; Wild Type Mouse; base; beta,beta-Carotene; beta,epsilon-Carotene-3,3'-diol, (3R,3'R,6'R)-; beta-caroten-3-ol; beta-carotene-3,3'-diol; body system, hepatic; cancer cell; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; carotenoic acid; cryptoxanthin; cultured cell line; dioxin receptor, nuclear translocator; experiment; experimental research; experimental study; fat metabolism; feeding; fruits and vegetables; gamma Lutein; heavy metal Pb; heavy metal lead; hepatic steatosis; in vivo; inhibitor; inhibitor/antagonist; interest; lipid metabolism; lycopene; macrophage; malignancy; monocyte; mouse model; neoplasm/cancer; ontogeny; organ system, hepatic; oxidation; pathway; pi bond; psi,psi-carotene; public health relevance; receptor; research study; response; retinol; social role; steroid X receptor; steroid and xenobiotic receptor; tool; transcription factor; zeaxanthin",Cleavage Products of Dietary Carotenoids: Occurrence & Nutritional Function," Project Narrative Increased consumption of dietary carotenoids is associated with decreased risk of both cardiovascular disease and certain cancers. The proposed research will document the occurrence of new pathways of metabolism of dietary carotenoids (the health-promoting, colored pigments in fruits and vegetables) in humans. The research will also explore possible mechanisms that may explain the basis of the health-promoting effects of these components of the diet.",49879,INMP,Integrative Nutrition and Metabolic Processes Study Section,A1,12,381250,
7783237,R01,HL,2,,01/11/2010,12/31/2010,PA-07-070,2R01HL056416-13A1,,NHLBI:385000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"BROXMEYER, HAL E.;",3092391;,2R01HL056416,04/01/1996,12/31/2013,"21+ years old; Acetylation; Active Oxygen; Adult; Age; Aging; Anaplastic; Antioncogene Protein p53; Anzatax; Apoptosis; Apoptosis Pathway; Asotax; BFU-E; BFU-E - Burst-form unit eryth; BFU-E - Burst-forming unit erythroid; Biology; Blood; Blood Cells; Blood Precursor Cell; Blood granulocytic cell; Blood, Cord; Blotting, Western; Bone Marrow; Bristaxol; CD117 Antigens; CD150; CD150 antigen; CDw150 protein; Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester; Cell Body; Cell Communication and Signaling; Cell Cycle; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Growth and Maintenance; Cell Lineage; Cell Maintenance; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Stress; Cellular Tumor Antigen P53; Chemicals; Cholinergic Differentiation Factor; Cytokines, Chemotactic; D-Factor; Data; Deacetylase; Deacetylation; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Disease; Disorder; EC 2.7; EC 2.7.2-; EPEG; ES Cell Line; ES cell; Embryonic Stem Cell Line; Embryonic Stem Cell Transplantation; Endomycetales; Enzymes; Eposide; Equilibrium; Erythroid; Etoposide; Event; Extracellular Signal-Regulated Kinases; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family; Fetal Liver; Generalized Growth; Genes; Genes, p53; Genotoxic Stress; Genotype; Grant; Granular Leukocytes; Granulocytic cell; Growth; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; History; Homologous Chemotactic Cytokines; Human Interleukin in DA Cells; Human, Adult; Hypoxia; Hypoxic; In Vitro; Intercrines; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; Knowledge; LIF; Laboratories; Lastet; Length of Life; Life; Light; Link; Longevity; MAP kinase; MAPK; METBL; MLPLI; Maintenance; Maintenances; Malignant; Malignant - descriptor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Maps; Marrow; Mast Cell Growth Factor Receptor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Melanoma-Derived LPL Inhibitor; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Mice; Mitogen-Activated Protein Kinases; Mother Cells; Murine; Mus; Nocodazole; Non-Malignant; O element; O2 element; Oncodazole; Oncoprotein p53; Oxygen; Oxygen Deficiency; Oxygen Radicals; Oxygen measurement, partial pressure, arterial; P53; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Peripheral Blood Cell; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Phosphotransferases; Photoradiation; Play; Population; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Praxel; Pro-Oxidants; Process; Production; Progenitor Cells; Progenitor Cells, Hematopoietic; Progress Reports; Proliferating; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein TP53; Protein p53; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proto-Oncogene Protein c-kit; Publications; RAFT1 protein, human; RAPT1 protein, human; Radiation; Rapamycin Target Protein; Reactive Oxygen Species; Recording of previous events; Regulation; Relative; Relative (related person); Replacement Therapy; Reports, Progress; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Spleen; Role; SCF Receptor; SIS cytokines; SLAM protein; Saccharomycetales; Scientific Publication; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Spleen; Stem Cell Factor Receptor; Stem Cell Transplantation, Embryonic; Stem cells; Stress; Stress, Genotoxic; Subcellular Process; TP53; TP53 gene; TRP53; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Techniques; Testing; Tissue Growth; Transphosphorylases; Tumor Protein p53; Tumor Protein p53 Gene; Umbilical Cord Blood; Undifferentiated; Units, Erythroid Burst-Forming; Vepesid; Western Blotting; Western Blottings; Western Immunoblotting; Withdrawal; Yeast, Budding; adult human (21+); age dependent; age related; arterial pO2; balance; balance function; biological adaptation to stress; biological signal transduction; c kit; c-kit Protein; c-kit Receptor; cell body (neuron); cell type; chemoattractant cytokine; chemokine; clinical applicability; clinical application; cytokine; disease/disorder; embryonic stem cell; fetal cord blood; gene product; granulocyte; human FRAP1 protein; improved; in vivo; insight; irradiation; kit Proto-Oncogene Protein; leukemia inhibitory factor; life span; lifespan; mTOR; macrophage; member; mutant; neural cell body; neuronal cell body; nonmalignant; ontogeny; oxygen tension; p145(c-kit); p145c-kit; p53 Antigen; p53 Tumor Suppressor; pathway; peripheral blood; progenitor; protein blotting; public health relevance; rapamycin and FKBP12 target 1 protein, human; ray (radiation); reaction; crisis; reconstitute; reconstitution; response; self-renewal; senescent; signaling lymphocytic activation molecule; signaling lympocyte activation molecule; social role; soma; stem; stem cell of embryonic origin; stress response; stress tolerance; stress; reaction",Mechanisms of Synergistic Regulation of Stem/Progenitors,,56416,HP,Hematopoiesis Study Section,A1,13,385000,
7786318,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL057531-10A2,,NHLBI:298000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW ORLEANS,UNITED STATES,PHYSIOLOGY,02,053785812,US,LA,70118,TULANE UNIVERSITY OF LOUISIANA,"PANDEY, KAILASH N;",1884242;,2R01HL057531,09/30/1997,01/31/2014,"ANF; ANF receptor A; ANH; ANP; ANP Receptors; ANP-sensitive guanylyl cyclase; ATP-protein phosphotransferase; Active Sites; Activities of Daily Living; Activities of everyday life; Affect; Area; Atrial; Atrial Natriuretic Factor; Atrial Natriuretic Factor Receptors; Atrial Natriuretic Peptides Receptors; Atriopeptins; Auricle of Heart; Auriculin; BNP Gene Product; BNP-32; BP control; Binding; Binding (Molecular Function); Biochemical; Biology; Blood Pressure, High; Blood Vessels; Blood Volume; Brain Natriuretic Peptide-32; Brain natriuretic peptide; Cardiac; Cardiac Atrium; Cardiovascular Diseases; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cell model; Cells; Cellular model; Chemotherapy-Hormones/Steroids; Complementary DNA; Confocal Microscopy; Consensus; Control Locus; Cultured Cells; Cyclic GMP; DNA, Complementary; Deoxyguanylate Cyclase; Diagnosis; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Down-Regulation, Receptor; Downregulation; Dysfunction; EC 2.7.2-; Embryo; Embryonic; Endocrine Gland Secretion; Event; Excretory function; External Domain; Extracellular Domain; Extracellular Signal-Regulated Kinases; Fluorescence; Fluorescence Microscopy; Functional disorder; GFP; GTP pyrophosphate-lyase (cyclizing); Generalized Growth; Genetics-Mutagenesis; Goals; Green Fluorescent Proteins; Growth; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanyl Cyclase; Guanylate Cyclase; Heart Atrium; Hormone Receptor; Hormones; Human; Human, General; Hypertension; In Vitro; Inosinate Cyclase; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Kidney; Knowledge; Learning; Leiomyocyte; Life; Ligands; Link; Liquid substance; MAP kinase; MAPK; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Mice, Transgenic; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitogen-Activated Protein Kinases; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Target; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Mutagenesis; Mutagenesis, Site-Directed; Myocytes, Smooth Muscle; Na element; Natriuretic Factor-32; Natriuretic Peptides, Atrial; Natriuretic factor, brain; Nature; Nesiritide; Nuclear; Organism-Level Process; Organismal Process; Pathogenesis; Phosphorylation; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Physiopathology; Play; Point Mutation; Protein Kinase; Protein Phosphorylation; Receptor Down-Regulation; Receptor Protein; Receptors, ANF; Receptors, Atrial Natriuretic Factor; Receptors, Atriopeptin; Recycling; Regulation; Research; Research Proposals; Risk Factors; Role; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Sodium; Stimulus; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic Hormone; Time; Tissue Growth; Transgenic Mice; Type-B Natriuretic Peptide; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vasodilatation; Vasodilation; Vasorelaxation; Work; atrial natriuretic factor receptor A; atrial natriuretic factor-R1; atrial natriuretic hormone; atrium; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; cDNA; cGMP; cardiovascular disorder; cell type; computerized data processing; daily living functionality; data processing; desensitization; disease/disorder; domain mapping; excretion; experiment; experimental research; experimental study; fluid; functional ability; functional capacity; glycogen synthase a kinase; guanosine 3'5' monophosphate; guanyl cyclase-A receptor; guanylyl cyclase; guanylyl cyclase-A; guanylyl cyclase-A receptor; hydroxyalkyl protein kinase; hyperpiesia; hyperpiesis; hypertension treatment; hypertensive disease; in vivo; insight; liquid; mesangial cell; mouse model; mutant; natriuretic peptide receptor 1; natriuretic peptide receptor A; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; pathophysiology; phosphorylase b kinase kinase; public health relevance; receptor; receptor function; receptor internalization; receptors, atrial natriuretic factor type A; renal; research study; response; signal processing; social role; trafficking; transcription factor; vascular",ANP Receptor: Molecular approach of signaling mechanisms," PROJECT NARRATIVE  Information gained from the proposed studies will yield a more accurate assessment of the integrative role of guanylyl cyclase-A/natriuretic peptide receptor-A (GC-A/NPRA) in possible mechanisms of pathogenesis whereby malregulation of receptor-mediated cardiac hormones; atrial and brain natriuretic peptides (ANP, BNP) bioactivity could result in abnormalities of fluid volume regulation and blood pressure homeostasis. Ultimately, this knowledge should yield new therapeutic molecular targets for the diagnosis, control, and treatment of hypertension and cardiovascular diseases.",57531,VCMB,Vascular Cell and Molecular Biology Study Section,A2,10,298000,
7780876,R01,HL,2,,01/07/2009,11/30/2010,PA-07-070,2R01HL057619-13,,NHLBI:438699;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,BIOCHEMISTRY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"TOWNES, TIM M.;",1880423;,2R01HL057619,09/30/1996,11/30/2014,"21+ years old; Adult; Alleles; Allelomorphs; B-globin; Biopsy Sample; Biopsy Specimen; Blood Precursor Cell; Blood erythrocyte; Blood normocyte; Cell Transplants; Cells; Childhood; Clinical Trials; Clinical Trials, Unspecified; Derivation; Derivation procedure; Differentiated Gene; Disease; Disorder; Erythrocytes; Erythrocytic; Erythroid Cells; Fibroblasts; Foundations; Future; Gene, Differentiated; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; HSC transplantation; Hb SS disease; HbSS disease; Hematopoietic; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hereditary; Human; Human, Adult; Human, General; Immunodeficient Mouse; Inherited; Insertional Mutagenesis; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Methods; Mice; Mouse Strains; Murine; Mus; Mutagenesis, Insertional; Mutation; Patients; Progenitor Cells, Hematopoietic; Protocol; Protocols documentation; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reticuloendothelial System, Erythrocytes; Sickle Cell; Sickle Cell Anemia; Skin; Testing; Translating; Translatings; Transplantation; Transplants, Cell; adult human (21+); beta Globin; blood corpuscles; clinical investigation; disease/disorder; drepanocyte; gene replacement therapy; genome mutation; homologous recombination; induced pluripotent stem cell; language translation; mouse model; novel therapeutic intervention; pediatric; progenitor; public health relevance; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; sickling; stem; stem cell differentiation; transplant",Gene Replacement Therapy for Sickle Cell Disease," Project Narrative We recently corrected sickle cell disease in our knockin mouse model by reprogramming skin fibroblasts into iPS (induced Pluripotent Stem) cells, replacing the defective sickle beta-globin gene with a normal beta-globin gene, differentiating the corrected iPS cells into hematopoietic progenitors and transplanting these cells into irradiated sickle mouse recipients. The goal of the present proposal is to translate these results to human cells. These studies will provide a foundation for future clinical trials in humans.",57619,ELB,Erythrocyte and Leukocyte Biology Study Section,,13,438699,
7779932,R01,HL,2,,01/18/2010,12/31/2010,PA-07-070,2R01HL060551-09A2,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,PATHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GONIAS, STEVEN L.;",1873369;,2R01HL060551,08/01/1999,12/31/2014,"Accounting; Alteplase; Amyloid A4 Protein Precursor; Amyloid Protein Precursor; Amyloid beta-Protein Precursor; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; ApoE Receptor; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Biological Models; Blood Coagulation Factor III; CD142 Antigens; Cachectin; Cachectin Receptors; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; Cell surface; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor III; Coagulin; Cytoplasmic Membrane; Data; Dysfunction; ERK MAP Kinases; Endocytosis; Event; Extracellular Matrix Proteins; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Factor III; Figs; Figs - dietary; Functional disorder; Funding; Gene Transcription; GeneHomolog; Genetic; Genetic Transcription; Glomerular Procoagulant Activity; Glycans; Goals; Grant; Homolog; Homologous Gene; Homologue; INFLM; Immunoglobulin Enhancer-Binding Protein; Inflammation; Inflammatory; Intracellular Communication and Signaling; LDL-Receptor Related Protein 1; Laboratories; Learning; Ligand Binding; Ligands; Link; Lipoprotein Receptor; Low Density Lipoprotein Receptor-Related Protein; Low-Density-Lipoprotein Receptor-Related Protein-1; Lysosomes; Macroglobulins; Mammals, Mice; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metallopeptidases; Metalloproteases; Metalloproteinases; Method LOINC Axis 6; Methodology; Mice; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Outcome; PLAT; Paper; Pathway interactions; Physiopathology; Pilot Projects; Plasma Membrane; Play; Polysaccharides; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Trafficking; Protein-Tyrosine Kinases, src; Proteins; Proteome; Proteomics; Prothrombinase; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RNA Expression; RPG; Receptor Protein; Receptor Signaling; Receptor, Apo E; Receptor, Apolipoprotein E; Recombinant Tissue Plasminogen Activator; Regulation; Reports, Progress; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; Surface Proteins; T-Plasminogen Activator; TNF (unspecified); TNF Receptor Family Protein; TNF Receptor Ligands; TNF Receptor Superfamily; TNF Receptors; TNF-alpha; TNFR; TTPA; Technology; Testing; Threonine/Tyrosine Protein Kinase; Thromboplastin; Thrombosis; Time; Tissue Activator D-44; Tissue Factor; Tissue Factor Procoagulant; Tissue Plasminogen Activator; Tissue Thromboplastin; Tissue-Type Plasminogen Activator; Traffickings, Protein; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; U-PA receptor; Urokinase Plasminogen Activator Receptor; Urokinase Receptor; Urokinase-type Plasminogen Activator Receptor; Urothromboplastin; Work; alpha-2-Macroglobulin Receptor; alpha2-Macroglobulin Signaling Receptor; amyloid precursor protein; atherogenesis; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; experiment; experimental research; experimental study; extracellular signal related kinase; gene product; improved; in vivo; in vivo Model; intercellular communication; kappa B Enhancer Binding Protein; macrophage; membrane structure; metalloproteinase (general); new approaches; novel; novel approaches; novel strategies; novel strategy; nuclear factor kappa beta; pathophysiology; pathway; pilot study; plasmalemma; programs; protein transport; public health relevance; receptor; receptor binding; receptor mediated endocytosis; receptor, pro-urokinase; research study; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; t-PA; tumor necrosis factor (unspecified); uPAR receptor",Regulation of Signaling Receptor Activity by LRP-1, Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms.,60551,HT,Hemostasis and Thrombosis Study Section,A2,9,386250,
7781745,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL063762-11,,NHLBI:396250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DALLAS,UNITED STATES,GENETICS,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"HERZ, JOACHIM J;",1990754;,2R01HL063762,02/01/2000,01/31/2015,"21+ years old; APOE [{C0003595}]; APOE epsilon4 protein, human; Adult; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acids; Aneurysm; Animal Model; Animal Models and Related Studies; Aorta; Apo-E; ApoE; ApoE Receptor; Apolipoprotein E; Arterial Fatty Streak; Arteries; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biological Models; Biotinylation; Blood; Blood Plasma; Blood Vessels; Brain; CD140B; CREB; CREB1; CREB1 gene; Carrier Proteins; Cell Communication and Signaling; Cell Fractionation; Cell Signaling; Cell surface; Cells; Cholest-5-en-3-ol (3beta)-; Cholesterol; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Encephalon; Encephalons; Endocytosis; Epidemic; Gene Family; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic screening method; Genotype; Glia; Glial Cells; Goals; Hand; Human; Human, Adult; Human, General; Hyperplasia; Hyperplastic; In Vitro; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; JTK12; Kinetic; Kinetics; Knock-out; Knockout; Knockout Mice; Kolliker's reticulum; LDL; LDL-Receptor Related Protein 1; LR7-8B; LRP8 protein; Leiomyocyte; Lesion; Life Expectancy; Ligands; Lipid Trafficking; Lipids; Lipoprotein LDL Receptors; Lipoprotein Receptor; Lipoproteins, LDL; Liver; Low Density Lipoprotein Receptor; Low Density Lipoprotein Receptor-Related Protein; Low-Density Lipoproteins; Low-Density-Lipoprotein Receptor-Related Protein-1; METBL; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Molecular; Mouse Protein; Mouse Strains; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Mutation; Myocytes, Smooth Muscle; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurological; Neuron Degeneration; Neurons; Non-neuronal cell; Null Mouse; Onset of illness; PDGF-R-Beta; PDGFR; PDGFR1; PDGFRB; PDGFRB gene; Pathogenesis; Physiologic; Physiological; Physiology; Plasma; Population; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Receptor Gene; Receptor Protein; Receptor Signaling; Receptor, Apo E; Receptor, Apolipoprotein E; Receptors, LDL; Receptors, N-Methylaspartate; Recycling; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Role; Serum, Plasma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Societies; Streaks, Arterial Fatty; Stream; Surface; Synaptic plasticity; Syndrome; Testing; Transport Proteins; Transporter Protein; VLDL receptor; Work; adult human (21+); age dependent; age related; alpha-2-Macroglobulin Receptor; alpha2-Macroglobulin Signaling Receptor; aminoacid; apo E-4; apo E4; apo epsilon4; apoE-4; apoE4; apoER2; apolipoprotein E receptor 2; apolipoprotein E receptor 2 gene product; apolipoprotein E-4; apolipoprotein E4; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; base; beta-Lipoproteins; biological signal transduction; body system, hepatic; dementia of the Alzheimer type; disease onset; disease/disorder; disorder onset; fat metabolism; gene product; genetic testing; genome mutation; immunocytochemistry; in vivo; lipid metabolism; lipid transport; low density lipoprotein receptor-related protein 8; model organism; mutant; nerve cement; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; novel; organ system, hepatic; primary degenerative dementia; public health relevance; receptor; receptor binding; receptor function; receptor recycling; reelin receptor; senile dementia of the Alzheimer type; social role; socioeconomic; socioeconomically; socioeconomics; subcellular fractionation; trafficking; vascular; very low density lipoprotein receptors; vulnerable plaque",Metabolism of the VLDL receptor and ApoE receptor 2," Atherosclerosis and neurodegeneration are two major age-related diseases in our Western societies. Apolipoprotein E, a lipid and cholesterol transport protein, is a major genetic modifier for both syndromes. This application investigates the role of ApoE receptors in cellular signaling pathways that are common to both disease processes and explores the molecular mechanisms by which certain ApoE genotypes predispose to vascular and neuronal pathogenesis.",63762,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,11,396250,
7782998,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL066171-09A1,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"FISHER, STEVEN A.;",1869287;,2R01HL066171,02/01/2001,01/31/2014,"Affinity; Alleles; Allelomorphs; Alternate Splicing; Alternative Splicing; Arteries; Arterioles; Assay; Be element; Be++ element; Beryllium; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blood Vessels; Blood flow; Body Tissues; C-terminal; Ca++ element; Calcium; Calponin Phosphatase; Cell Communication and Signaling; Cell Signaling; Coagulation Factor IV; Code; Coding System; Combining Site; Conserved Sequence; Contracting Opportunities; Contracts; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DISSEC; Data; Deletion Mutation; Development; Dimerization; Disease; Disease model; Disorder; Dissection; Exons; Factor IV; Figs; Figs - dietary; Flies; Funding; Gene Expression; Gene Transcription; GeneHomolog; Generations; Genes; Genes, LacZ; Genetic Transcription; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Homolog; Homologous Gene; Homologue; In Vitro; In element; Indium; Intervening Sequences; Intracellular Communication and Signaling; Introns; Investigation; Isoforms; LacZ; LacZ Genes; Leucine Zippers; Link; Measurement; Mediating; Mesenteric; Mesenteric Arteries; Mesentery; Metabolic; Modeling; Molecular; Molecular Interaction; Muscle Relaxation; Muscle relaxation phase; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Mutation Analysis; Myosin-Light-Chain Phosphatase; Nodal; PKG; Perinatal; Phenotype; Portal Vein; Portal vein structure; Pressure; Pressure- physical agent; Production; Property; Property, LOINC Axis 2; Protein Dimerization; Protein Isoforms; Protein Kinase G; Proteins; RNA Expression; RNA Splicing; RNA Splicing, Alternative; Reactive Site; Reading Frames; Regulation; Relaxation; Reporter; Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Myosins; Smooth muscle (tissue); Splicing; Structure of arteriole; Testing; Time; Tissue Model; Tissue-Specific Splicing; Tissues; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenic Organisms; Veins; arteriole; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; disease/disorder; disorder model; experiment; experimental research; experimental study; fly; gain of function; gene product; guanosine 3'5' monophosphate; in vivo; insight; knock-down; loss of function; myosin phosphatase; novel; pressure; public health relevance; research study; resistant; social role; trait; transgenic; vascular; vascular bed",Smooth Muscle Myosin Phosphatase Subunit Isoforms," Project Narrative The smooth muscle of the small resistance arteries by contracting and relaxing is the primary regulator of blood flow to the tissues. The proposed experiments will test the role of Transformer proteins, master determinants of sexual features in flies, in regulating gene expression and function of the small arteries in development and disease.",66171,VCMB,Vascular Cell and Molecular Biology Study Section,A1,9,392500,
7784337,R01,HL,2,,01/15/2010,11/30/2010,PA-07-070,2R01HL068728-06A1,,NHLBI:434931;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,OBSTETRICS & GYNECOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"FIGUEROA, JORGE PABLO;",1900220;,2R01HL068728,12/01/2001,11/30/2013,"21+ years old; Adult; Adult Children; Adult Daughters; Adult Sons; Animals; BP control; Betadexamethasone; Betamethasone; Blood Pressure; Blood Pressure, High; Blood Vessels; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Celestone; Chronic; Clinical; Common Rat Strains; Coronary Disease; Coronary heart disease; Data; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Dose; Dysfunction; EDN1; ET-1; ET-1 (Endothelin-1); Effects, Longterm; Elements; Endothelin; Endothelin Type 1; Endothelin-1; Endothelium-Derived Vasoconstrictor Factors; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Event; Exposure to; Fats; Fatty acid glycerol esters; Feedback; Fetus; Flubenisolone; Functional disorder; Funding; Glucocorticoids; Glucose Intolerance; Human; Human, Adult; Human, General; Humulin R; Hypertension; Impairment; In Vitro; Incidence; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Kidney; Life; Lipolysis; Long-Term Effects; METBL; MODY; Mammals, Rats; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Metabolic; Metabolic Processes; Metabolic syndrome; Metabolism; Muscle, Involuntary; Muscle, Skeletal; Muscle, Smooth; Muscle, Voluntary; NIDDM; Nephrons; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Offspring, Adult; Organ System, Cardiovascular; Ovis; Perinatal Exposure; Physiology; Physiopathology; Play; Polycystic Ovarian Disease; Polycystic Ovary Syndrome; Populations at Risk; Predisposition; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-; Preventive Intervention; Rat; Rattus; Receptor Protein; Renal function; Renin-Angiotensin System; Risk Factors; Role; Sclerocystic Ovarian Degeneration; Sclerocystic Ovary Syndrome; Sheep; Skeletal Muscle Tissue; Skeletal muscle structure; Smooth muscle (tissue); Stein Lenventhal syndrome; Stein-Leventhal Syndrome; Steroid Compound; Steroids; Structure; Susceptibility; System; System, LOINC Axis 4; T2D; T2DM; Testing; Therapeutic; Therapeutic Glucocorticoid; Type 2 diabetes; Type II diabetes; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; Uriniferous Tube; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; adiposity; adult human (21+); adult onset diabetes; base; blood pressure control; blood pressure homeostasis; blood pressure regulation; cardiac hypertension; cardiovascular disorder; circulatory system; clinical relevance; clinically relevant; coronary disorder; corpulence; corpulency; corpulentia; diabetic; disease/disorder; fetal; fetal exposure; fetal programming; glucose tolerance; heart disease hypertension; heart disorder hypertension; heart hypertension; hyperpiesia; hyperpiesis; hypertensive cardiomyopathy; hypertensive disease; hypertensive heart disease; hypertensive heart disorder; in utero; in utero exposure; in vivo; insulin resistant; insulin sensitivity; intra-uterine environmental exposure; intrauterine environmental exposure; ketosis resistant diabetes; kidney function; maturity onset diabetes; modifiable risk; obese; obese people; obese person; obese population; pathophysiology; polycystic ovary; polycystic ovary disease; polycystic ovary disorder; postnatal; prenatal; prenatal exposure; prenatally exposed; prevent; preventing; preventional intervention strategy; public health relevance; receptor; renal; response; social role; treatment program; unborn; vascular",Prenatal Glucocorticoid and Postnatal Blood Pressure," PROJECT NARRATIVE  In humans and in animals, antenatal glucocorticoid exposure is associated with elevations in blood pressure and glucose tolerance abnormalities. The proposed studies will determine if the endothelin system plays a critical role in the development of these abnormalities and if obesity in adulthood magnifies the alterations already present in those exposed prenatally to glucocorticoid. This information will aid in establishing new preventive interventions and therapeutic approaches in populations at risk for developing hypertension in adult life.",68728,PN,Pregnancy and Neonatology Study Section,A1,6,434931,
7782231,R01,HL,2,,01/04/2010,12/31/2010,PA-07-070,2R01HL069851-06A1,,NHLBI:367080;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,RICHMOND,UNITED STATES,OBSTETRICS & GYNECOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"WALSH, SCOTT W;",1903304;,2R01HL069851,04/01/2002,12/31/2013,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2 Dimensional Gel Electrophoresis; ANG-(1-8)Octapeptide; Abdomen; Abdominal; Accounting; Active Oxygen; Adhesion Molecule; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Anionic Neutrophil-Activating Peptide; Antibodies; Antioxidants; Arteries; Bizzozero's corpuscle/cell; Blood Neutrophil; Blood Plasma; Blood Platelets; Blood Polymorphonuclear Neutrophil; Blood Pressure; Blood Segmented Neutrophil; Blood Vessels; Blotting, Western; Body Tissues; C section; C-Section (OB); CD54 (ICAM 1); CD54 Antigens; CLG; CLG1; COX-2 protein; COX2; COX2 enzyme; Cachectin; Cachectin-Tumor Necrosis Factor; Calponin Phosphatase; Candidate Disease Gene; Candidate Gene; Cardiovascular Diseases; Cardiovascular Physiology; Cell Adhesion Molecules; Cell Culture Techniques; Cell-Extracellular Matrix; Cell/Tissue, Immunohistochemistry; Cells; Cesarean section; Chemistry; Chemotactic Factor, Macrophage-Derived; Chemotactic Factor, Neutrophil; Chemotactic Factor, Neutrophil, Monocyte-Derived; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cyclo-Oxygenase-2; Cyclooxygenase; Cytokines, Chemotactic; DIF; DNA Methylation; DNA Sequence Analysis; Deetjeen's body; Delivery, Abdominal; Dysfunction; EC 2.7; ECM; ELISA; Effects, Longterm; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Endothelium; Enzyme-Linked Immunosorbent Assay; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Extracellular Matrix; Fats; Fatty acid glycerol esters; Fibroblast Collagenase; Functional disorder; Future; GCP-IL-8; Genes; Gestation; Gestosis, EPH; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Granulocyte Chemotactic Peptide-Interleukin-8; HNC; Hayem's elementary corpuscle; Health; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Human; Human, General; ICAM-1; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ; Inflammation; Inflammatory; Inflammatory Response; Intercellular adhesion molecule 1; Intercrines; Interleukin-8; Interstitial Collagenase; Kinases; Leiomyocyte; Leukocyte Adhesion Inhibitor; Levarterenol; Levonorepinephrine; Life; Long-Term Effects; MMP-1; MMP-1Fibroblast Collagenase; MMP-8; MMP1; MMP8; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow platelet; Matrix Metalloproteinase-1; Matrix Metalloproteinase-8; Measures; Mediating; Methylation; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Neutrophil Activating Peptide; Neutrophil Activation; Neutrophil Activation Factor; Neutrophil Activation Peptide; Neutrophil Collagenase; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophil-Activating Peptide, Lymphocyte-Derived; Neutrophil-Activating Peptide, Monocyte-Derived; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Noradrenaline; Norepinephrine; Nuclear; Omental Fat; Omentum; Operation; Operative Procedures; Operative Surgical Procedures; Oxidative Stress; Oxygen Radicals; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PMNL Collagenase; PMNL-CL; PTGS2; Pathology; Patients; Pattern; Peroxidases; Phenotype; Phosphorylation; Phosphotransferases; Physiopathology; Plasma; Platelets; Poisons; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Pre-Eclampsia; Preeclampsia; Pregnancy; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Methylation; Protein Phosphorylation; Proteinuria-Edema-Hypertension Gestosis; Reactive Oxygen Species; Recurrence; Recurrent; Reporter; Research; Reticuloendothelial System, Platelets; Reticuloendothelial System, Serum, Plasma; Risk; Role; SIS cytokines; Science of Chemistry; Sequence Analyses, DNA; Sequence Analysis, DNA; Serum, Plasma; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Stains, Tissue; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TNF; TNF A; TNF gene; TNF-alpha; TNFSF2; Testing; Thrombocytes; Thromboxane Production; Thromboxanes; Time; Tissue Stains; Tissues; Toxemias, Pregnancy; Toxic Chemical; Toxic Substance; Transfection; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-alpha; Vascular System; Vascular constriction (function); Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Western Blotting; Western Blottings; Western Immunoblotting; Woman; anti-oxidant; bisulfite; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cardiovascular function; cell adhesion protein; chemoattractant cytokine; chemokine; cyclo-oxygenase II; cyclooxygenase 2; cytokine; fetal; hydrogen sulfite; hydrosulfite; imprint; inflammatory marker; inhibitor; inhibitor/antagonist; mutant; myosin phosphatase; neutralizing antibody; neutrophil; novel; oxidant stress; pathophysiology; poison; pregnancy toxemia/hypertension; pregnant; programs; prostaglandin H synthase-2; protein blotting; public health relevance; response; social role; subcutaneous; surgery; thrombocyte/platelet; toxic compound; vascular; vascular inflammation; vasopressor",Oxidant Stress Mechanisms in Preeclampsia," Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. This research will test the hypothesis that vascular inflammation due to neutrophil infiltration is critical to the pathophysiology of preeclampsia. This hypothesis encompasses molecular explanations for a vicious cycle that reinforces vascular inflammation in preeclampsia, and creates an epigenetic imprint in the maternal vascular system that may predispose women to chronic cardiovascular disease.",69851,PN,Pregnancy and Neonatology Study Section,A1,6,367080,
7785492,R01,HL,2,,01/12/2010,11/30/2010,PA-07-070,2R01HL072012-06A1,,NHLBI:342880;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,BIOMEDICAL ENGINEERING,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"SCHILD, JOHN H;",1896794;,2R01HL072012,12/01/2002,11/30/2013,"Afferent Neurons; Afferent Pathways; Age; Agreement; Aortic arch structure; Aquadiol; Arch of the Aorta; Arch, Aortic; Autonomic nervous system; Baroreceptors; Baroreflex; Binding; Binding (Molecular Function); Blood Pressure; Blood Pressure, High; Brain Stem; Brainstem; Calcium-Activated Potassium Channel; Cardiovascular; Cardiovascular Body System; Cardiovascular Pathology; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cells; Chemotherapy-Hormones/Steroids; Chronotropism, Cardiac; Chronotropisms, Cardiac; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Companions; Coupled; Data; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Endocrine Gland Secretion; Equilibrium; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exhibits; Female; Fiber; Foundations; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gender; Gender Bias; Gonadal Steroid Hormones; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Health; Heart Rate; Hormones; Hypertension; In Vitro; Investigation; Ion Channel; Ion Channels, Potassium; Ionic Channels; Isoforms; K Cells; K channel; K element; K+ Channels, Ca2+-Activated; K+ Channels, Calcium-Activated; Killer Cells; Lead; Literature; Location; Mammals, Rats; Measures; Mediating; Membrane; Membrane Channels; Method LOINC Axis 6; Methodology; Molecular Interaction; Myxoid cyst; Nerve; Nerve Cells; Nerve Fibers; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System Physiology; Neural Cell; Neural Ganglion; Neural Transmission; Neurobiology; Neurocyte; Neurologic function; Neurological function; Neuronal Transmission; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology - biologic function; Nucleus Tractus Solitarii; Nucleus solitarius; Organ System, Cardiovascular; Outcome; Ovocyclin; Ovocylin; Pathology; Pathway interactions; Pb element; Physiologic; Physiological; Population; Potassium; Potassium Channel; Pre-Menopause; Pre-menopausal Period; Premenopausal; Premenopausal Period; Premenopause; Preparation; Pressoreceptors; Pressure; Pressure- physical agent; Process; Progynon; Property; Property, LOINC Axis 2; Protein Isoforms; Protocol; Protocols documentation; Rat; Rattus; Receptor Protein; Reflex; Reflex action; Reflex control; Reflex, Baroreceptor; Regulation; Role; Science of neurophysiology; Sensory; Sensory Cell Afferent Neuron; Sex Bias; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Sexism; Slice; Solitary Nucleus; Stretch Receptors, Arterial; Stretch Receptors, Vascular; Synaptic Transmission; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Time; Transmission; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Woman; aortic arch; balance; balance function; cardiovascular function; circulatory system; disease/disorder; experiment; experimental research; experimental study; gender difference; gonadal steroids; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; male; membrane structure; men; men's; nervous system function; neural; neural control; neural function; neural regulation; neurobiological; neuronal; neurophysiology; neuroregulation; neurotransmission; normotensive; novel; patch clamp; pathway; pre-menopausal; pressure; public health relevance; receptor; receptor function; relating to nervous system; research study; response; sex dimorphism; sex steroid; sexual dimorphism; sexual dimorphism (noncellular); social role; solitary tract nucleus; transmission process",Gender differences in aortic baroreceptor function and neural integration," PROJECT NARRATIVE  Gender differences in cardiovascular function are well known and while sex hormones are important contributing factors, there is growing evidence for alternative mechanisms. This project aims to determine if there are fundamental neuroanatomical and neurophysiological differences in the baroreceptor afferent pathway between men and women. Evidence for a gender-related difference in baroreceptors could potentially lead to novel advances in the effective management of cardiovascular health and disease in the female population.",72012,HM,Hypertension and Microcirculation Study Section,A1,6,342880,
7735487,R01,HL,2,,02/01/2010,01/31/2011,PAR-07-352,2R01HL073646-06,,NHLBI:1402759;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"WICKLINE, SAMUEL A;",1876170;,2R01HL073646,04/01/2003,01/31/2012,"Acute; Adhesion Molecule; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenesis, Pathologic; Angiogenesis, Pathological; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Animal Model; Animal Models and Related Studies; Animals; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiangiogenesis Agents; Antiangiogenic Agents; Antiinflammatories; Antiinflammatory Agents; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Biological Factors; Blood Serum; Blood Vessels; Body Tissues; CD106; CD106 Antigens; Cancers; Cardiovascular Diseases; Care, Health; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; Clinical; Clinical Trials; Clinical Trials, Unspecified; Compensation; Computer Programs; Computer software; Contrast Agent; Contrast Drugs; Contrast Media; Data; Detection; Development Plans; Diagnostic; Dose; Drug Kinetics; Evaluation; Exhibits; Extracellular Matrix, Integrins; Factor, Biologic; Fibrin; Financial compensation; Fluorocarbons; Gadolinium; Gd element; Healthcare; Host Defense; Human; Human, General; INCAM-110; Image; Inducible Cell Adhesion Molecule 110; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Injection of therapeutic agent; Injections; Integrins; Intracellular Communication and Signaling; Kinetic; Kinetics; Legal patent; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Measurable; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Molecular Interaction; Motion; NMR Imaging; NMR Tomography; Natural Products; Neovascularization Inhibitors; Neovascularization, Pathological; Nuclear Magnetic Resonance Imaging; Outcome; Patents; Pathologic Neovascularization; Pathology; Peptide Domain; Peptides; Perfluorocarbons; Pharmacokinetics; Phase; Physiologic pulse; Plans, Development; Protein Domains; Pulse; Radiopaque Media; Rapamune; Rapamycin; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Software; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Streaks, Arterial Fatty; Syndrome; Technology Transfer; Tertiary Protein Structure; Therapeutic; Therapeutic Agents; Time; Tissues; Universities; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Washington; Work; Zeugmatography; analog; angiogenesis; antiangiogenic; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; base; biological signal transduction; biomarker; cardiovascular disorder; cell adhesion protein; clinical applicability; clinical application; clinical investigation; computer program/software; design; designing; flexibility; fumagillin; imaging; in vivo; malignancy; model organism; molecular imaging; nano emulsion; nano particle; nanoemulsion; nanoparticle; neoplasm/cancer; new diagnostics; new technology; next generation diagnostics; novel; novel diagnostics; particle; public health relevance; response; therapeutic target; vascular; vulnerable plaque",METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICS," Over the initial term of this BRP proposal, our partnership has designed, developed, and demonstrated in animal models an array of diagnostic targeted perfluorocarbon nanoparticle approaches for use at 1.5T and 3T (clinical), and 4.7 and 11.7T (experimental) MRI field strengths for application in early, advanced, and unstable atherosclerotic plaque. The anticipated outcome of this translational work will be the first clinical trial-based proof-of-concept for a new molecularly targeted contrast agent, representing a specific and selective magnetic resonance image-based biomarker that is capable of detecting and quantifying angiogenesis-facilitated pathologies such as atherosclerosis.",73646,ZRG1,Special Emphasis Panel,,6,1402759,
7799586,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL076206-05A2,,NHLBI:379937;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"ABRAHAM, EDWARD ;",8556136;,2R01HL076206,03/01/2004,01/31/2014,"55-kDa High-Affinity Calcium Binding Protein; Acute; Acute Pulmonary Injury; Affect; Antigenic Surface Determinant Protein OA3 Gene; Apoptotic; Bacteria; Binding; Binding (Molecular Function); Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; CAB-63; CBP3 (Liver); CD31; CD47; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) Gene; CD47 Glycoprotein Gene; CD47 gene; Calcium-Binding Protein-3; Calregulin; Cell Communication and Signaling; Cell Signaling; Chemosensitization; Chemosensitization/Potentiation; Chemotaxis; Clotting; Coagulation; Coagulation Process; Collagenous Lectins; Collectins; Complement S-Protein; Data; Development; ERp60; Eating; Epibolin; Extracellular Matrix, Integrins; Fibrinolyses; Fibrinolysis; Food Intake; Funding; Goals; HACBP; Heterophil Granulocyte; IAP Gene; Incidence; Integrin-Associated Protein Gene; Integrins; Intracellular Communication and Signaling; Kringle Domains; Kringles; Laboratories; Leukocyte Surface Antigen CD47 Gene; Ligands; Lung; Lung Injury, Acute; MER6 Gene; Marrow Neutrophil; Molecular Interaction; Neutrophil Activation; Neutrophilic Granulocyte; Neutrophilic Leukocyte; OA3 Gene; Opsonin; PAI-1; PAI1; PECAM1; PECAM1 gene; PLANH1; PLAU; Pathway interactions; Patients; Perfusion; Phagocytosis; Plasminogen Activator Inhibitor 1; Plasminogen Activator, Urokinase; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Potentiation; Property; Property, LOINC Axis 2; Receptor Protein; Research; Respiratory System, Lung; Role; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Serum Spreading Factor; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Surface Antigen Identified by Monoclonal Antibody 1D8 Gene; TIL4; TLR2; TLR2 gene; TLR4; TLR4 gene; TOLL; Thrombosis; Tissues; Toll/Interleukin 1 Receptor-Like 4 Gene; Type 1 Plasminogen Activator Inhibitor; U-PA; U-Plasminogen Activator; UPA; Urinary Plasminogen Activator; Urokinase; Urokinase-Type Plasminogen Activator; VTN; Vitronectin; acute lung injury; biological signal transduction; cC1qR Protein; calreticulin; hToll; improved; in vivo; lung injury; macrophage; neutrophil; novel; novel therapeutic intervention; pathway; public health relevance; pulmonary; receptor; receptor expression; social role","Urokinase, Neutrophil Activation and Acute Lung Injury."," Project Narrative Description Urokinase, plasminogen activator inhibitor 1 (PAI-1), and vitronectin have well described roles in modulating coagulation and fibrinolysis. However, our recent results suggest two novel mechanisms through which urokinase, PAI-1, and vitronectin can contribute to the development of acute lung injury independently of their effects on coagulation and fibrinolytic pathways: 1) by enhancing neutrophil activation and 2) by decreasing phagocytosis and clearance of neutrophils in the lungs. The studies proposed in this application should not only improve understanding of cellular mechanisms leading to acute lung injury, but also are likely to suggest novel therapeutic interventions aimed at decreasing the incidence and/or severity of acute lung injury.",76206,LIRR,"Lung Injury, Repair, and Remodeling Study Section",A2,5,379937,
7812747,R01,HL,2,,02/01/2010,01/31/2011,PA-07-070,2R01HL076684-05,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"WEINTRAUB, NEAL L;",1921877;,2R01HL076684,04/01/2004,01/31/2014,"ANG-(1-8)Octapeptide; Abdominal Aortic Aneurysm; Active Oxygen; Adoptive Transfer; Age-Years; Aged 65 and Over; American; Amino Acids; Aneurysm; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensins; Aorta; Aortic Aneurysm, Abdominal; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Pressure, High; Blood Segmented Neutrophil; Blood Vessels; Blood leukocyte; Blood monocyte; Body Tissues; Cardiovascular Diseases; Data; Death, Sudden; Deterioration; Development; Disease; Disorder; Elastases; Elderly; Elderly, over 65; Enzymes; Esteroproteases; Ethanesulfonic acid, 2-amino-; Experimental Animal Model; Experimental Models; Experimental Models, Other; Genetic; Heterophil Granulocyte; Human; Human, General; Hypertension; INFLM; Incidence; Inflammation; Infusion; Infusion procedures; Lead; Leukocytes; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Marrow monocyte; Mediating; Medical; Mice; Modeling; Models, Experimental; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NADPH Oxidase; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Oxidative Stress; Oxygen Radicals; Pathogenesis; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Peroxidases; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Pro-Oxidants; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Reactive Oxygen Species; Research; Resistance; Reticuloendothelial System, Leukocytes; Role; Rupture; Source; Sudden Death; Supplementation; Tauphon; Taurine; Testing; Tissues; Transgenic Animals; Transgenic Organisms; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; White Blood Cells; White Cell; advanced age; aminoacid; atheromatosis; atherosclerotic vascular disease; cardiovascular disorder; denitration; disease/disorder; elders; gene product; geriatric; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; inhibitor; inhibitor/antagonist; insight; late life; later life; macrophage; monocyte; neutrophil; nitration; novel; older adult; older person; oxidant stress; pathway; prevent; preventing; public health relevance; resistant; senior citizen; social role; transgenic; vascular; white blood cell; white blood corpuscle","Angiotensin II, oxidative stress and aneurysm formation"," Project narrative- Abdominal aortic aneurysms are common in elderly Americans and can lead to progressive enlargement and even rupture of the aorta, the largest blood vessel in the body. Our research suggests that an enzyme known as myeloperoxidase, which is present in white blood cells, contributes to inflammation and tissue damage within the aorta, leading to aneurysm formation. The purpose of our research is to investigate the role of myeloperoxidase in aneurysm formation in experimental animal models, and then to determine whether countermeasures against myeloperoxidase may be effective in treating aneurysms in humans.",76684,ZRG1,Special Emphasis Panel,,5,392500,
7792847,R01,HL,2,,01/15/2010,12/31/2010,PA-07-070,2R01HL077731-06,,NHLBI:370000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"BUSIJA, DAVID W;",1864987;,2R01HL077731,09/01/2004,12/31/2013,"Active Oxygen; Address; Age; Aging; Aging Process; Aging-Related Process; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Apoplexy; Area; Arteries; Blood; Blood Vessels; Cell Communication and Signaling; Cell Signaling; Cells; Cerebral Arteries; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Chronic; Cognitive; Common Rat Strains; Consumption; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Dilator; Dimethylbiguanidine; Dimethylguanylguanidine; Dose; Drug Prescribing; Drug Prescriptions; Dysfunction; Elements; Endothelium; Endothelium, Vascular; Fructose; Functional disorder; Humulin R; INSR; Imidodicarbonimidic diamide, N,N-dimethyl-; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Resistance; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Ion Channels, Potassium; K channel; Lead; Levulose; MODY; Mammals, Rats; Maturity-Onset Diabetes Mellitus; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic syndrome; Metformin; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; NIDDM; Nature; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Oxygen Radicals; Pb element; Physiologic; Physiological; Physiopathology; Population Research; Potassium Channel; Prescriptions, Drug; Primary Senile Degenerative Dementia; Pro-Oxidants; Protocols, Treatment; RGM; Rat; Rats, Sprague-Dawley; Rattus; Reactive Oxygen Species; Regimen; Replacement Therapy; Research; Reticuloendothelial System, Blood; Role; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Smooth muscle (tissue); Sprague-Dawley Rats; Stress; Stroke; Structure of cerebral artery; T2D; T2DM; Testing; Therapeutic; Therapeutic Agents; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; Type 2 diabetes; Type II diabetes; Vascular Accident, Brain; Vascular Endothelium; Vascular resistance; adiposity; adult onset diabetes; aged; aging population; biological signal transduction; brain attack; cerebral artery; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; cerebrovascular; corpulence; corpulency; corpulentia; dementia of the Alzheimer type; diabetic patient; glucose transport; heavy metal Pb; heavy metal lead; improved; insulin resistant; insulin signaling; ketosis resistant diabetes; maturity onset diabetes; neglect; nervous system disorder; neurological disease; neuronal; normal aging; novel; obese; obese people; obese person; obese population; pathophysiology; preconditioning; prevent; preventing; primary degenerative dementia; protective effect; public health relevance; response; restoration; senescent; senile dementia of the Alzheimer type; social role; stroke; vascular",Potassium channel dysfunction in cerebral arteries," PROJECT NARRATIVE Revelance: Chronic cerebral vascular insufficiency as occurs in IR and in aging and leads to neurological diseases such as non-specific cognitive deficiency, Alzheimer's Disease and strokes but the potential role of insulin has not been studied. Current treatment regimens are not optimal and we expect that the results of our studies will lead to new and improved therapies to prevent or slow the onset of neurological diseases in an obese and aging population.",77731,ZRG1,Special Emphasis Panel,,6,370000,
7779827,R01,HL,2,,04/01/2010,03/31/2011,PA-07-070,2R01HL077783-05,,NHLBI:366295;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,PHYSIOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"BLALOCK, J. EDWIN;",3052517;,2R01HL077783,04/01/2006,03/31/2014,"3-10C; 4q Chemokine; AMCF-I; Acute; Address; Alveolar; Animals; Antiproteases; Arts; Binding; Binding (Molecular Function); Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood monocyte; Bronchoalveolar Lavage Fluid; C-X-C Chemokines; CF patients; CXC Chemokines; CXCL8; CXCR; Cause of Death; Chemicals; Chronic; Chronic lung disease; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collagen; Cystic Fibrosis; Diagnosis; Disease; Disorder; ESI; Effectiveness; Electrospray Ionization; Endopeptidase Inhibitors; Enzymes; Evaluation; Exposure to; GCP-1; GCP1; Generations; Graft Rejection; Heterophil Granulocyte; Human; Human, General; Hypertrophy, Right Ventricular; IL-8; IL8; IL8 gene; INFLM; Immunologist; In Vitro; Individual; Inflammation; K60; LC/MS; LECT; LUCT; LYNAP; Lead; Ligands; Lung; Lung diseases; MDNCF; MONAP; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow monocyte; Mediating; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods and Techniques; Methods, Other; Modeling; Molecular Interaction; Mucoviscidosis; NAF; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pathway interactions; Patients; Pb element; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Peptides; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Production; Protease Antagonists; Protease Inhibitor; Proteinase Inhibitors; Pulmonary Diseases; Pulmonary Disorder; Reaction; Receptor Protein; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Right Ventricular Hypertrophy; Role; Route; SCYB8; Signal Pathway; Smoking; Solutions; Sputum; Structure; TSG-1; Techniques; Testing; Therapeutic; Therapeutic Agents; Transplant Rejection; Transplantation Rejection; Work; aerosolized; airway epithelium infalmmation; airway inflammation; alpha-Chemokines; analog; b-ENAP; biomarker; cigarette smoke; clinical investigation; cofactor; cystic fibrosis patients; disease/disorder; heavy metal Pb; heavy metal lead; in vivo; insight; liquid chromatography mass spectrometry; lung disorder; metalloproteinase (general); monocyte; mouse model; multidisciplinary; neutrophil; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; parent grant; pathway; patients with CF; patients with cystic fibrosis; post-proline cleaving enzyme; post-proline endopeptidase; preclinical study; prolinal; proline aldehyde; proline endopeptidase; proline specific endopeptidase; prolyl endopeptidase; prolyl endopeptidase (thiol-dependent); prolyl endopeptidase I; prolyl oligopeptidase; public health relevance; pulmonary; receptor; receptor binding; response; smoke of cigarettes; social role; therapeutic target",A New Pathway for Neutrophil-induced Airway Inflammation," PROJECT NARRATIVE: COPD is now the fourth leading cause of death in the U.S. and is expected to be the third by 2020. This disease causes much human suffering as well as a large monetary burden. An understanding of COPD that leads to successful therapeutics has been hampered by a lack of biomarkers to diagnose and use as endpoints in clinical trials as well as a lack of a fundamental understanding of the disease process itself. If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets.",77783,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,5,366295,
7781581,R01,HL,2,,02/01/2010,11/30/2010,PA-07-279,2R01HL078665-05A2,,NHLBI:423750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"TURNBULL, DANIEL H;",1870007;,2R01HL078665,09/22/2004,11/30/2013,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 21+ years old; 3-D analysis; 3-dimensional analysis; 3D analysis; Address; Adult; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animals; Area; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Avidin; Binding; Binding (Molecular Function); Biological; Biotin; Biotinylation; Birth; Blood Vessels; Blood flow; Body Tissues; Brain; Cancers; Cardiac; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Function; Cell Process; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Contrast Agent; Contrast Drugs; Contrast Media; Defect; Development; Diabetes Mellitus; Diagnosis, Ultrasound; Disease; Disease Progression; Disorder; Echography; Echotomography; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Event; Face; Future; Gene Expression; Gene Targeting; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetically Engineered Mouse; Genital System, Female, Uterus; Health; Heart; Histology; Human Development; Human, Adult; Image; Imagery; Injection of therapeutic agent; Injections; Investigation; Knockout Mice; Label; Laboratories; Life; Link; Liver; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Membrane Proteins; Membrane-Associated Proteins; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microbubbles; Modeling; Molecular; Molecular Interaction; Morphology; Motion; Murine; Mus; Mutation; NMR Imaging; NMR Tomography; Nature; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Nucleic Acid Regulatory Sequences; Null Mouse; Optical Methods; Optics; Organ; Organ System; Organ System, Cardiovascular; Parturition; Pathogenesis; Pattern; Penetration; Physiologic; Physiological; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Radiopaque Media; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Reporter; Reporting; Research; Research Specimen; Resolution; Respiration; Role; Rotation; Science of Anatomy; Specimen; Staging; Subcellular Process; Surface; Surface Proteins; System; System, LOINC Axis 4; Targetings, Gene; Testing; Three-dimensional analysis; Time; Tissues; Transgenes; Transgenic Mice; Transgenic Organisms; Translations; Ultrasonic Biomicroscopy; Ultrasonic Imaging; Ultrasonic bio-microscopy; Ultrasonogram; Ultrasonographic Biomicroscopy; Ultrasonography; Ultrasound Biomicroscopies; Ultrasound Test; Ultrasound, Medical; Uterus; Vascular Endothelial Cell; Vascular System; Vascular, Heart; Virus; Viruses, General; Visualization; Vitamin H; Zeugmatography; adult human (21+); anatomy; atheromatosis; atherosclerotic vascular disease; body system; body system, hepatic; cardiac motion; cardiac scanning; cardiovascular disorder; cardiovascular imaging; circulatory system; coenzyme R; design; designing; diabetes; diagnostic ultrasound; disease/disorder; facial; fetal; flexibility; gene product; genetic regulatory element; genome mutation; genome, mouse; heart imaging; heart motion; heart scanning; hemodynamics; human disease; imaging; imaging modality; improved; in utero; in vivo; insight; interest; malignancy; model organism; molecular imaging; mouse genome; mouse model; neoplasm/cancer; neovascularization; novel; optic imaging; optical imaging; organ system, hepatic; programs; public health relevance; reconstruction; respiratory mechanism; social role; sonogram; sonography; sound measurement; tool; transgene expression; transgenic; ultrasound; ultrasound imaging; ultrasound scanning; vascular; womb",Molecular UBM and MRI of Vascular Development," This project aims to move ultrasound and MRI vascular micro-imaging methods beyond measures of anatomy and function, to the level of in vivo molecular imaging in genetically-engineered mouse models of a wide range of cardiovascular disease. These new molecular imaging approaches will revolutionize mouse genetics, enabling new studies linking gene expression to vascular morphology and physiological function in the best characterized mammalian model of human development and disease.",78665,MEDI,Medical Imaging Study Section,A2,5,423750,
7790958,R01,HL,2,,01/04/2010,12/31/2010,PA-07-070,2R01HL079424-05,,NHLBI:448500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,RICHMOND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"KUKREJA, RAKESH C.;",1888685;,2R01HL079424,01/01/2005,12/31/2013,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; Abbott brand of sildenafil citrate; Adenosine; Adriamycine; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Artegodan Brand of Amfepramone Hydrochloride; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Bayer brand of vardenafil hydrochloride; Bioavailability; Biologic Availability; Biological Availability; Blood Vessels; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiomyopathies; Cardiovascular Diseases; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell model; Cellular model; Chronic; Cialis; Clinical Trials; Clinical Trials, Unspecified; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; D-Glucose; DNA Binding; DNA Binding Interaction; DOX; Delgamer; Deoxyguanylate Cyclase; Development; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetic mouse; Doxorubicin; Doxorubicina; Drugs; Dysfunction; EC 1.1.3.22; EC 2.7; Endogenous Nitrate Vasodilator; Endothelium; Endothelium-Derived Relaxing Factor; Erectile dysfunction; Fasting; Functional disorder; GTP pyrophosphate-lyase (cyclizing); GUCY; Gene Expression; Gene Transfer; Generations; Glucose; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanyl Cyclase; Guanylate Cyclase; Heart; Heart Hypertrophy; Heart failure; Heart myocyte; Hoechst Brand of Amfepramone Hydrochloride; Human; Human, General; Humulin R; Hydrolysis; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Hyperglycemia; Hypoxanthine Dehydrogenase; Hypoxanthine Oxidase; Hypoxanthine-Xanthine Oxidase; Impairment; Injury; Inosinate Cyclase; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intracellular Communication and Signaling; Investigation; Ischemia-Reperfusion Injury; Ischemic Preconditioning; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; Knowledge; Lead; Levitra; Lilly brand of tadalafil; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MODY; Mammals, Mice; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Marion Merrell Brand of Amfepramone Hydrochloride; Marion Merrell Dow Brand of Amfepramone Hydrochloride; Maturity-Onset Diabetes Mellitus; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic Diseases; Metabolic Disorder; Mice; Molecular; Mononitrogen Monoxide; Murine; Mus; Muscle; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Tissue; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardial Infarct; Myocardial Infarction; Myocardiopathies; Myocytes, Cardiac; NADPH Oxidase; NIDDM; Nitric Oxide; Nitric Oxide Signaling Pathway; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Oryctolagus cuniculus; Oxidative Stress; Oxis; PDE 5 enzyme; PKG; PRKM8; Patients; Pb element; Pfizer brand of sildenafil citrate; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Physiologic Availability; Physiopathology; Play; Population; Preconditionings, Ischemic; Process; Production; Protein Kinase G; Protein Phosphorylation; Pulmonary Edema; Purine-Xanthine Oxidase; Rabbit, Domestic; Rabbits; Reperfusion Damage; Reperfusion Injury; Role; SAPK1; Sclerosis; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sildenafil citrate; Silenafil Citrate; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase; T2D; T2DM; Tenuate; Testing; Therapeutic Effect; Thesaurismosis; Transphosphorylases; Type 2 diabetes; Type II diabetes; Vasodilatation; Vasodilation; Vasorelaxation; Viagra; Xanthine Oxidase; Xanthine[{..}]oxygen oxidoreductase; Xanthines; acute coronary syndrome; adiposity; adult onset diabetes; atheromatosis; atherosclerotic vascular disease; base; bioavailability of drug; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiomyocyte; cardiovascular disorder; cardiovascular risk; cardiovascular risk factor; clinical investigation; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cytokine; db/db mouse; diabetic; diabetic cardiomyopathy; diabetic cardiopathy; diabetic cardiopathy disease; diabetic cardiopathy disorder; diabetic cardiovascular disease; diabetic cardiovascular disorder; diabetic patient; drug/agent; endothelial cell derived relaxing factor; fasted; fasts; glucose uptake; guanosine 3'5' monophosphate; guanylyl cyclase; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; hyperglycemic; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; insulin resistant; ketosis resistant diabetes; lung edema; maturity onset diabetes; men; men's; metabolism disorder; mitoK(ATP); mitoKATP; mitochondrial K(ATP) channel; model organism; mouse model of diabetes; myocardium disorder; necrocytosis; nitric oxide receptor; nitric oxide-sensitive guanylyl cyclase; nitrosative stress; novel; obese; obese people; obese person; obese population; overexpression; pathophysiology; phosphodiesterase V; phosphodiesterase-5; prevent; preventing; protective effect; public health relevance; receptor-mediated signaling; sGC; sGC protein; sildenafil; social role; tadalafil; tool; transfer of a gene; vardenafil; vascular",Cardioprotective Effects of PDE-5 Inhibitors," LAY NARRATIVE Obesity and type 2 diabetes are two of the most prevalent metabolic disorders in the world. Type II diabetes is associated with insulin resistance and increased myocardial infarction in both animal models and patients. In this proposal, we will study a new strategy for the protection of the heart and treatment of insulin resistance in Type II diabetic mice with erectile dysfunction drugs (Viagra(R) and Cialis(R)) and a novel drug BAY 58 2667 which produces cGMP - a potent muscle relaxing molecule in the body. We believe that knowledge derived from these studies will provide additional tools to the cardiologists in reducing damage of the heart following a heart attack and treatment of heart failure in diabetic patients. Moreover, our studies will help understand the molecular basis of the protection with these drugs.",79424,MIM,Myocardial Ischemia and Metabolism Study Section,,5,448500,
7782419,R01,HL,2,,01/12/2010,11/30/2010,PA-07-070,2R01HL079460-06,,NHLBI:371778;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"DAVIS, GEORGE E;",1871485;,2R01HL079460,02/01/2005,11/30/2013,"Address; Adventitial Cell; Affect; Antiproteases; Basement membrane; Biosynthetic Proteins; Blood Vessels; Bone-Derived Transforming Growth Factor; CD140b Antigens; CLG; Caliber; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell-Extracellular Matrix; CellLine; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen IV; Collagen Type IV; DT-R; DTR; DTR gene; DTS; Deposit; Deposition; Development; Diabetes Mellitus; Diameter; Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) Gene; Diphtheria Toxin Receptor Gene; Diphtheria Toxin Sensitivity Gene; ECM; Endopeptidase Inhibitors; Endothelial Cells; Environment; Event; Extracellular Matrix; Fibroblast Collagenase; Funding; GFAC; Gene Expression; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HB-EGF; HBEGF; HEGFL; Heparin-Binding EGF-Like Growth Factor Gene; Human TIMP-3; Human Tissue Inhibitor of Metalloproteinase-3; Individual; Interstitial Collagenase; Intracellular Communication and Signaling; MMP-1; MMP-10; MMP-1Fibroblast Collagenase; MMP-X1; MMP1; MMP14 gene; MT1-MMP; MTMMP1; Malignant Neoplasms; Malignant Tumor; Matrix Metalloproteinase-1; Mediating; Milk Growth Factor; Modeling; Molecular; Morphogenesis; PDGF-BB; PDGF-R-Beta; PDGFR beta; PDGFR1; PDGFRB; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Pericapillary Cell; Pericytes; Perivascular Cell; Phenotype; Platelet Transforming Growth Factor; Platelet-Derived Growth Factor Receptor Beta Polypeptide; Platelet-Derived Growth Factor beta Receptor; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protease Antagonists; Protease Inhibitor; Proteinase Inhibitors; Proteins; Receptor Protein; Receptor, PDGF beta; Recombinant Proteins; Recruitment Activity; Role; Rouget Cells; Scanning; Series; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Structure; Supporting Cell; Surface; TGF B; TGF-beta; TGFbeta; TIMP-3; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta; Tube; Type IV (Basement Membrane) Collagen; Work; attenuation; biological signal transduction; cardiovascular disorder; cell type; cultured cell line; cytokine; diabetes; gene product; hTIMP; human disease; in vitro Model; in vivo; insight; malignancy; matrix metalloproteinase 10; neoplasm/cancer; novel; platelet-derived growth factor BB; programs; public health relevance; receptor; recruit; social role; stromelysin 2; transin 2; vascular; vasculogenesis",Pericyte proteinase inhibitors and EC tube stabilization," Project Narrative This work focuses on the ability of pericytes, a cell type surrounding small blood vessels, to support the integrity of these cell-lined tube structures. These support cells produce a series of proteins that facilitate this support mechanism. A basic understanding of the mechanisms underlying how blood vessels form and become stabilized is critical in efforts to stimulate or inhibit the process in the context of various human diseases such as cardiovascular disease, diabetes or cancer.",79460,CDD,Cardiovascular Differentiation and Development Study Section,,6,371778,
7786399,R01,HL,2,,01/21/2010,12/31/2010,PA-07-070,2R01HL079571-06,,NHLBI:415000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MANHASSET,UNITED STATES,,05,110565913,US,NY,11030,FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH,"LIPTON, JEFFREY M;",1920862;,2R01HL079571,09/30/2004,12/31/2014,"Adrenal Cortex Hormones; Affect; Anemia; Apoptotic; Biological; Biology; Birth Defects; Blood erythrocyte; Blood normocyte; Bone marrow failure; Canada; Cancers; Causality; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Complex; Conduct Clinical Trials; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Corticoids; Corticosteroids; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Development; Diagnosis; Diagnostic; Diamond-Blackfan anemia; Disease; Disease remission; Disorder; Dysmyelopoietic Syndromes; Epidemiology; Erythrocyte Aplasia; Erythrocytes; Erythrocytic; Erythroid; Etiology; Event; Family; Forecast of outcome; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genotype; Goals; Health Care Professional; Health Care Providers; Health Personnel; Health Professional; Health profession; Healthcare Providers; Healthcare professional; Healthcare worker; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematologist; Hematopoiesis; Hematopoietic; Hematopoietic Cancer; Hematopoietic Cellular Control Mechanisms; Hereditary; Hereditary Disease; Incidence; Individual; Inherited; International; Investigation; Knowledge; Laboratories; Laboratory Study; Lead; Link; Literature; Malignant Hematologic Neoplasm; Malignant Neoplasms; Malignant Tumor; Marrow erythrocyte; Modality; Molecular; Molecular Disease; Molecular Genetic Abnormality; Mutate; Mutation; Myelodysplastic Syndromes; Outcome; Pancytopenia; Patients; Pb element; Pedigree; Penetrance; Phenotype; Population; Predisposition; Production; Prognosis; Proteins; Protocols, Treatment; Publishing; Pure Red-Cell Aplasia; RGM; RMSN; Rare Diseases; Rare Disorder; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Red-Cell Aplasia, Pure; Regimen; Registries; Remission; Reporting; Research; Research Resources; Resources; Reticuloendothelial System, Erythrocytes; Ribosomal Proteins; Ribosomes; Sampling; Screening procedure; Smoldering Leukemia; Study of epidemiology; Subcellular Process; Susceptibility; Syndrome; Testing; Therapeutic; Therapeutic Corticosteroid; Therapeutic Human Experimentation; Therapeutic Research; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States; base; blood corpuscles; cancer risk; clinical care; clinical data repository; clinical data warehouse; data repository; demographics; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; early childhood; epidemiology study; experiment; experimental research; experimental study; gene discovery; gene product; genetic disorder; genetic pedigree; genome mutation; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; hereditary disorder; improved; infancy; infantile; insight; interest; malignancy; medical personnel; myelodysplasia; neoplasm/cancer; outcome forecast; patient population; pedigree structure; public health relevance; relational database; reproductive; research study; response; screening; screenings; tool; treatment provider; treatment response",A Vital Tool for the Study of DBA:The Diamond Blackfan Anemia Registry," Relevance By exploiting a well-characterized patient population, the Diamond Blackfan Anemia Registry, the molecular basis of red blood cell production and its link to ribosome assembly and function and cancer predisposition, can be explored. The goal of this project is to utilize this database for detailed analysis of the degree of anemia, treatment response, presence of congenital anomalies and development of cancer in DBA patients. This will lead to insights into the etiology of birth defects and cancer in these patients and in the population at large and ultimately lead to improved clinical care for DBA patients.",79571,CASE,Cardiovascular and Sleep Epidemiology Study Section,,6,415000,
7785130,R01,HL,2,,01/04/2010,12/31/2010,PA-07-070,2R01HL081741-05,,NHLBI:354000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN DIEGO,UNITED STATES,,53,933863508,US,CA,92161,VETERANS MEDICAL RESEARCH FDN/SAN DIEGO,"HAMMOND, H. KIRK ;",1917872;,2R01HL081741,09/01/2005,12/31/2013,"3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; AAV vector; ATP; ATP pyrophosphate-lyase (cyclizing); Action Potentials; Acute; Adenosine 5'-(tetrahydrogen triphosphate); Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine Triphosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenoviral Vector; Adenovirus Vector; Adenyl Cyclase; Adenylate Cyclase; Adenylpyrophosphate; Adenylyl Cyclase; Adrenergic Receptor; Adrenoceptors; Adverse effects; Ala-Asp; Alanine; Alanine, L-Isomer; Amino Acid Substitution; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Aspartic Acid; Assay; Award; Bioassay; Biodistribution; Biologic Assays; Biological; Biological Assay; C 1 Esterase; C1 Esterase; C1 s; C1s; Cardiac; Cardiac Myocytes; Cardiac Toxicity; Cardiocyte; Cardiotoxicity; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell membrane; Cells; Chimera Protein; Chimeric Proteins; Clinical; Complement 1 Esterase; Complement 1s; Complement component C1s; Coronary Occlusions; Coupling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; DNA; Data; Deoxyribonucleic Acid; Disease; Disorder; Drugs; Effector Cell; Engineering; Engineerings; Event; Family suidae; Foundations; Funding; Fusion Protein; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gene Transfer; Generations; HTRPY; Hand; Heart; Heart failure; Heart myocyte; Hypertrophy; In Vitro; Intracellular Communication and Signaling; Isoforms; L-Alanine; L-Aspartic Acid; Laboratories; Left; Left Ventricles; Left ventricular structure; Length; Logic; Measures; Medication; Methods; Mice, Transgenic; Modeling; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial; Myocytes, Cardiac; Nomenclature; Nuclear Envelope; Nuclear Membrane; Nucleic Acid Regulatory Sequences; Occlusions, Coronary; Organ; Outcome; PKA; Parents; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Pigs; Plasma Membrane; Plasmids; Position; Positioning Attribute; Pre-Clinical Model; Preclinical Models; Production; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase A; Protein Phosphorylation; Proteins; Protocol; Protocols documentation; Receptors, Epinephrine; Recombinants; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research Design; Reticulum; Route; SERCA2a; Safety; Series; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Study Type; Suidae; Swine; TM Domain; Testing; Therapeutic; Time; TnI; Transgenes; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Translations; Transmembrane Domain; Transmembrane Region; Treatment Side Effects; Troponin I; Ventricular; Virus; Viruses, General; adeno vector; adeno-associated viral vector; adeno-associated virus vector; adenoreceptor; adenosine 3'5' monophosphate; adenovector; adenylcyclase; alanylaspartic acid; base; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cardiac failure; cardiac occlusion; cardiomyocyte; clinical applicability; clinical application; clinical relevance; clinically relevant; design; designing; disease/disorder; drug/agent; efficacy testing; experiment; experimental research; experimental study; expression vector; gene product; gene transfer vector; genetic regulatory element; heart function; heart occlusion; improved; improved functioning; in vivo; inhibitor; inhibitor/antagonist; inhibitory troponin I; language translation; lipofection; model organism; mutant; phospholamban; plasmalemma; porcine; pre-clinical; preclinical; protein protein interaction; public health relevance; research study; safety testing; side effect; study design; suid; therapeutic transgene; therapy adverse effect; transfer of a gene; transgene expression; transgenic; treatment adverse effect; vector",Mechanisms of Adenylyl Cyclase Effects in the Heart," Project Narrative We have modified adenylyl cyclase type 6 (AC6), a molecule that regulates cardiac function. This modified AC6 (AC6mut) preserves the beneficial effects on the heart that are seen with AC6, but does so in the absence of increased cAMP production. In patients with heart failure, drugs that improve heart function by increasing cAMP levels have failed to reduce mortality. Our studies will determine if this modified AC6 molecule will be a suitable heart failure treatment.",81741,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,5,354000,
7785173,R01,HL,2,,01/05/2010,12/31/2010,PA-07-070,2R01HL081844-05A1,,NHLBI:331691;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,PATHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TAYLOR, JOAN M.;",7948096;,2R01HL081844,06/15/2005,12/31/2013,"21+ years old; Acute; Adult; Asses; BPTP3; Birth; Buffers; CFC; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cardiomyopathy, Hypertrophic Obstructive; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Signaling; Cells; Cephalic; Chronic; Clinical; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cranial; Cues; Cultured Cells; Cytokinesis; Cytoplasmic Division; Cytosolic Protein Tyrosine Phosphastase; DNA Synthesis Factor; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Depressed mood; Development; Diagnosis; Disease; Disorder; Donkey; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; ECGF; Embryo; Embryonic; Endothelial Cell Growth Factor; Equus asinus; Extracellular Matrix, Integrins; FADK; FAK; FAK1; FGF; FGF9; FGF9 gene; FLR; Face; Failure (biologic function); Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Functional disorder; Funding; GAF; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth; HBFG-9; HBGF; HTRPY; Heart; Heart Diseases; Heart failure; Heart myocyte; Human; Human, Adult; Human, General; Hypertrophic Cardiomyopathy; Hypertrophy; Hypoxia; Hypoxic; In Vitro; Injury; Integrins; Intracellular Communication and Signaling; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Lead; Locales; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mechanical Stress; Mediating; Mice; Modeling; Molecular; Morphogenesis; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Mutation; Myocardial; Myocardial Ischemia; Myocardium; Myocytes; Myocytes, Cardiac; NS1; Neonatal; Oxygen Deficiency; PTK2; PTK2 gene; PTP-1D; PTP2C; PTPN11; PTPN11 gene; PTPase; Parturition; Pathogenesis; Patients; Pb element; Phase; Phenocopy; Phenotype; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Physiopathology; Play; Population; Pressure; Pressure- physical agent; Process; Protein Tyrosine Phosphatase; Receptor Protein; Recovery; Regulation; Reperfusion Therapy; Research; Role; SH-PTP2; SH-PTP3; SHP-2; SHP2; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stress; Stress, Mechanical; Syndrome; Testing; Time; Tissue Growth; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Ventricular; Ventricular Dysfunction; Withdrawal; Work; adult human (21+); base; biological signal transduction; cardiac failure; cardiac muscle; cardiomyocyte; clinical data repository; clinical data warehouse; clinical significance; clinically significant; congenital cardiac disorder; congenital heart disease; congenital heart disorder; data repository; depressed; disease/disorder; effective therapy; facial; failure; gain of function; genome mutation; heart cell; heart disorder; heart ischemia; heart muscle; heavy metal Pb; heavy metal lead; hypertrophic myocardiopathy; in vivo; inhibitor; inhibitor/antagonist; interest; loss of function; mouse model; muscle form; myocardial ischemia/hypoxia; myocardium ischemia; neovascularization; ontogeny; pathophysiology; pp125FAK; pressure; protein tyrosine phosphate phosphohydrolase; public health relevance; receptor; relational database; reperfusion; repository; response; sadness; selective expression; selectively expressed; social role",FAK Signaling in cardiac growth and hypertrophy," RESEARCH AND RELATED Other Project Information 7. Project Narrative We strive to understand the molecular mechanisms that regulate the ability of heart cells to divide, since strategies to manipulate this function could be efficacious in the context of several congenital heart diseases and heart failure. While heart cells can undergo division during development, alterations of the timing or locale of division can lead to congenital heart disease. Furthermore, these cells loose the ability to divide shortly after birth, thus any damage to the heart can cause irreversible loss of function.",81844,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",A1,5,331691,
7797289,R01,MH,2,,01/15/2010,12/31/2010,PA-07-070,2R01MH065420-05A2,,NIMH:475383;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DETROIT,UNITED STATES,PSYCHIATRY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"STANLEY, JEFFREY A.;",8141467;,2R01MH065420,01/15/2010,12/31/2014,"0-11 years old; 11 year old; 12-20 years old; 14 year old; AD/HD; ADHD; Accounting; Active Follow-up; Address; Adolescence; Adolescent; Adolescent Youth; Affect; Age; Age Group Unspecified; Aminoethanols; Anterior; Area; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Basal Ganglia; Basal Nuclei; Behavior; Behavioral; Bilateral; Biochemical; Biochemistry; Brain; Brain region; Chemistry, Biological; Child; Child Youth; Childhood; Children (0-21); Choline Chloride Dihydrogen Phosphate; Choline Phosphate; Choline Phosphate Chloride; Cognition; Cognitive; Corpus Striatum; Corpus striatum structure; Data; Dendrites; Development; Dorsal; Dysfunction; Encephalon; Encephalons; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride; Ethanolamines; Foundations; Frequencies (time pattern); Frequency; Functional disorder; Funding; Gender; Generalized Growth; Goals; Gray; Gray unit of radiation dose; Growth; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Image; Lead; Left; Longitudinal Studies; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Measurement; Measures; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Health Services; Mental Hygiene Services; Methods; Methods and Techniques; Methods, Other; Modeling; Motor; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Development; Neurocyte; Neurodevelopmental Disorder; Neurological Development Disorder; Neurons; Neuropil; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Parietal; Pathogenesis; Pathway interactions; Pb element; Perception; Performance; Phosphatides; Phosphocholine; Phospholipids; Phosphorous; Phosphorylcholine; Phosphorylcholine Chloride; Physiopathology; Play; Prefrontal Cortex; Process; Protocol; Protocols documentation; Public Health; Recruitment Activity; Regulation; Relative; Relative (related person); Resolution; Role; Short-Term Memory; Socio-economic status; Socioeconomic Status; Solid; Specificity; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Status, Socioeconomic; Striate Body; Striatum; Surface; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Testing; Thick; Thickness; Time; Tissue Growth; Treatment outcome; Visit; Weight; Work; Zeugmatography; adolescence (12-20); age group; attention deficit hyperactive disorder; base; children; eleven year old; ethanolamine phosphate; executive control; executive function; experiment; experimental research; experimental study; follow-up; fourteen year old; heavy metal Pb; heavy metal lead; imaging; improved; in vivo; juvenile; juvenile human; long-term study; membrane structure; motivational processes; motor control; neurodevelopment; neuroimaging; neuronal; neuropsychological; ontogeny; pathophysiology; pathway; pediatric; performance tests; phosphodiester; phosphoethanolamine; phosphomonoester; phosphorylethanolamine; public health medicine (field); public health relevance; recruit; research study; social role; striatal; substantia alba; teenage; ultra high resolution; white matter; working memory; youngster",Assessing Development Trajectories of the Brain Biochemistry in ADHD at 4 Tesla," Assessing Developmental Trajectories of the Brain Biochemistry in ADHD at 4 Tesla Stanley, Jeffrey A. PROJECT NARRATIVE  Attention Deficit Hyperactivity Disorder (ADHD) is a serious public health problem that affects between 3 to 9% of children and accounts for between 30 to 40% of child referrals to mental health services. While the cause of this illness remains poorly understood, ADHD is increasingly seen as a neurodevelopmental disorder. This work promises to identify where in the brain and at what age certain alterations occur in children and adolescents with ADHD, and this information of changes with age can then potentially be used as a predictor of treatment outcome.  .",65420,CPDD,Child Psychopathology and Developmental Disabilities Study Section,A2,5,475383,
7786398,R01,MH,2,,01/06/2010,12/31/2010,PA-07-070,2R01MH065541-06A2,,NIMH:385768;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,STANFORD,UNITED STATES,BIOPHYSICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"MADISON, VERNON DANIEL;",1908193;,2R01MH065541,06/01/2002,12/31/2014,"AMPA Receptors; Abscission; Addiction, Drug; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Anxiety Disorders; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Brain; Chemical Dependence; Chemosensitization; Chemosensitization/Potentiation; Complex; Cornu Ammonis; D Aspartate; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Dependence, Drug; Depotentiation; Depressed mood; Depression; Disease; Disorder; Drug Addiction; Drug Dependency; Emotions; Encephalon; Encephalons; Endocytosis; Environment; Excision; Excitatory Synapse; Extirpation; Fear; Frequencies (time pattern); Frequency; Fright; Grant; Hippocampus; Hippocampus (Brain); Homosynaptic Depression; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Individual; Kanner's Syndrome; Knowledge; Learning; Learning Disabilities; Learning disability; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Maps; Membrane; Memory; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Modeling; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic; Neurological; Neuromediator Receptors; Neurons; Neurophysiology - biologic function; Neuroregulator Receptors; Neurotransmitter Receptor; Physics; Plastics; Play; Population; Postsynaptic Membrane; Potentiation; Primary Senile Degenerative Dementia; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Public Health; Publishing; Receptor Protein; Receptors, AMPA; Receptors, N-Methylaspartate; Receptors, Neurohumor; Removal; Research; Role; Specific qualifier value; Specified; Surface; Surgical Removal; Synapses; Synaptic; Synaptic Membranes; Synaptic Transmission; Synaptic plasticity; Techniques; Testing; Unspecified Mental Disorder; Variant; Variation; addiction; aspartate receptor; aspartic acid receptor; base; dementia of the Alzheimer type; depressed; design; designing; disease/disorder; effective therapy; hippocampal; intervention design; long term depression; membrane structure; mental illness; neural function; neuronal; postsynaptic; presynaptic; primary degenerative dementia; psychological disorder; public health medicine (field); public health relevance; quantum; receptor; resection; sadness; senile dementia of the Alzheimer type; social role; therapy design; trafficking; treatment design",Plasticity in Unitary Synaptic Connections," The processes of synaptic plasticity have traditionally been associated with learning and memory, but in fact underlie practically everything the brain does, and have been strongly implicated in a variety of physical and mental disorders, including, but certainly not limited to: Alzheimer's disease, Huntington's disease, autism, anxiety disorders, drug addiction, learning disabilities, and many more. Discovery of the underlying mechanisms of synaptic plasticity is so fundamental to understanding scores of mental disorders, that designing effective treatments and/or cures for these disorders without this knowledge would be akin to trying to learn quantum physics without first knowing the alphabet. The relevance of this proposed research to public health is that it will provide new knowledge key to designing treatments for many nervous and mental disorders, and thus, will greatly assist in the improvement of the public's mental health.",65541,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",A2,6,385768,
7789438,R01,MH,2,,01/15/2010,11/30/2010,PA-07-070,2R01MH068725-06A2,,NIMH:503463;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN FRANCISCO,UNITED STATES,,08,613338789,US,CA,941211545,NORTHERN CALIFORNIA INSTITUTE RES & EDUC,"VINOGRADOV, SOPHIA ;",1897355;,2R01MH068725,07/01/2003,11/30/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 21+ years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Acetylcholine; Adult; Ammon Horn; Attention; BDNF; Behavioral; Blood Serum; Brain; Brain-Derived Neurotrophic Factor; CMHC; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Chronic Schizophrenia; Clinical; Cognition; Cognitive; Cognitive remediation; Communities; Community Mental Health Centers; Computer Assisted; Computers; Control Groups; Coping Skills; Cornu Ammonis; Data; Development; Dopamine; Dose; Effectiveness; Employment; Employment, Supported; Encephalon; Encephalons; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Event; Exercise; Exercise, Physical; Feasibility Studies; Fostering; Goals; Hippocampus; Hippocampus (Brain); Hour; Human, Adult; Hydroxytyramine; Individual; Instruction; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Job Environment; Job Location; Job Place; Job Setting; Job Site; Laboratories; Learning; Levarterenol; Levonorepinephrine; MGC34632; Measures; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Health; Mental Hygiene; Mental Patients; Mentally Ill; Mentally Ill Persons; Methods; Motivation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocognition; Neurocognitive; Neurocyte; Neuronal Plasticity; Neurons; Neurosciences; Neurosciences Research; Noise; Noradrenaline; Norepinephrine; Occupational; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Measure; Participant; Patients; Phase; Process; Programs (PT); Programs [Publication Type]; Psychological Health; QOL; Quality of life; Randomized Controlled Trials; Recovery; Relative; Relative (related person); Research; Rewards; SCHED; San Francisco; Schedule; Schizoaffective Disorders; Schizophrenia; Schizophrenic Disorders; Sensory; Serum; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Skills, Coping; Social Functioning; Supported Employment; Surgical; Surgical Interventions; Surgical Procedure; Testing; Training; Training Programs; Verbal Learning; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; active control; adult human (21+); base; biological signal transduction; cognitive training; community setting; computer aided; computerized; dementia praecox; evidence base; functional outcomes; hippocampal; improved; interest; interventional strategy; neural plasticity; neuronal; neuroplasticity; primary outcome; processing speed; programs; psychosocial; psychosocial rehabilitation; public health relevance; randomized controlled study; response; schizophrenic; secondary outcome; social; supportive employment; surgery; translational neuroscience; work environment; work setting; working memory",Cognitive Remediation of Schizophrenia in a Community Mental Health Setting, PROJECT NARRATIVE This purpose of this study is to investigate the usefulness of neuroscience-guided cognitive training combined with community-based supported employment for people with schizophrenia. We will examine the effectiveness of moving our study of neuroplasticity-based restorative targeted cognitive training out of the laboratory and into the community setting; and we will also investigate its utility in enhancing functional outcome in chronically mentally ill adults who are participating in supported employment.,68725,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",A2,6,503463,
7781696,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS014841-31,,NINDS:1081082;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROSCIENCES,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RAKIC, PASKO ;",7858334;,2R01NS014841,05/01/1991,01/31/2015,"21+ years old; Address; Adhesives; Adult; Affect; Animals; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Autopsy; Birth Defects; Brain; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cerebral cortex; Childhood; Cognition Disorders; Cognitive; Column of Bertini; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cortical Column; Data; Defect; Development; Developmental reading disorder; Disease; Dislocations; Disorder; Dose; Drugs; Dyslexia, Developmental; Electroporation; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Environmental Factor; Environmental Risk Factor; Epilepsy; Epileptic Seizures; Epileptics; Event; Exposure to; FLR; Failure (biologic function); Feasibility Studies; Fetal Age; Fetal Maturity, Chronologic; Gene Family; Generations; Genes; Genetic; Gestation; Gestational Age; Glia; Glial Cells; Goals; Grant; Human; Human, Adult; Human, General; IHC; Immigrations; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; In-Migration; Individual; Intracellular Communication and Signaling; Investigation; Joint Dislocation; Kanner's Syndrome; Knock-out; Knockout; Knockout Mice; Kolliker's reticulum; Lateral; Lead; Left; Macaca; Macaque; Mammals, Mice; Mammals, Primates; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Mental Retardation; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microscopy; Molecular; Molecular Analysis; Molecular Genetic Abnormality; Monkeys; Murine; Mus; Neocortex; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Growth; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurological Disorders; Neuronal Growth; Neurons; Non-neuronal cell; Null Mouse; Pathogenesis; Pathology; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiology; Position; Positioning Attribute; Pregnancy; Prevention; Primates; Process; Production; Publishing; R01 Mechanism; R01 Program; RPG; Radial; Reading Disability, Developmental; Regulation; Relative; Relative (related person); Renal Column of Bertini; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rodent; Rodentia; Rodentias; Role; Sampling; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Supersonic waves; Synapses; Synaptic; Technology; Testing; Therapeutic; Time; Ultrasonic wave; Ultrasound waves; adult human (21+); biological signal transduction; cognitive disease; cognitive disorder; cognitive function; dementia praecox; disease/disorder; drug/agent; environmental risk; epilepsia; epileptiform; epileptogenic; failure; fetal; heavy metal Pb; heavy metal lead; homotypical cortex; in utero; in vivo; insight; isocortex; malformation; migration; multi-photon; necropsy; neopallium; nerve cement; nervous system disorder; neurogenesis; neurogenetics; neurological disease; neuronal; non-human primate; nonhuman primate; notch; notch protein; notch receptors; pediatric; postmortem; postnatal; public health relevance; schizophrenic; social role",Neurogenetic Processes in the Fetal Brain," NARRATIVE: The identity, synaptic connections and physiology of neurons that underlie the highest cognitive functions in the adult cerebral cortex are to a great extent defined by their laminar, columnar and areal positions that are achieved during early embryonic development by active and precise orchestration of neuronal production and migration from multiple sites of origin. The disruption or even slight slowing of migration by either genetic or environmental factors may results in failure of the proper number of neurons to reach their ""addresses"" and cause either large malformations that are easily detectable, or a subtle misplacement of individual neurons that could be entirely missed by routine examination in both alive or autopsied human brains. We hypothesize that even small elimination or slight dislocation of neurons may be involved in a variety of idiopathic neurological disorders that range from childhood epilepsy and mental retardation to schizophrenia, autism and developmental dyslexia. Thus, we propose to continue our investigation of cellular and molecular mechanisms of normal and abnormal cortical neurogenesis to obtain new insight into the causes of these disorders that may lead to their prevention or therapy.",14841,DBD,Developmental Brain Disorders Study Section,,31,1081082,
7779184,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS015751-29A2,,NINDS:341250;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SEATTLE,UNITED STATES,PHARMACOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"CATTERALL, WILLIAM A;",1866716;,2R01NS015751,12/01/1979,12/31/2013,"ATP-protein phosphotransferase; Action Potentials; Activation Analysis; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Amino Acid Substitution; Analyses, Activation; Arrhythmia; Attention; Basic Research; Basic Science; Binding; Binding (Molecular Function); Biophysics; Brain; C protein; CBP protein (citrate-binding); Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cardiac Arrhythmia; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Charge; Chemotherapy-Hormones/Steroids; Complex; Coupled; Cyclic AMP-Dependent Protein Kinases; Cysteine; DNA Molecular Biology; Defect; Dependence; Disease; Disorder; Disulfides; EC 2.7; Encephalon; Encephalons; Endocrine Gland Secretion; Epilepsy; Epileptic Seizures; Epileptics; Extensive Disease; Familial Hypokalemic Periodic Paralysis; Gene Expression; Generalized Disease; Genetic Alteration; Genetic Change; Genetic defect; Half-Cystine; Headache, Migraine; Health; Heart; Heart Arrhythmias; Hereditary; Hormones; Hypokalemic periodic paralysis; Impairment; Inherited; Intracellular Communication and Signaling; Ion Channels, Sodium; Ions; Kinases; L-Cysteine; Maps; Measures; Membrane; Migraine; Modeling; Models, Molecular; Molecular; Molecular Biology; Molecular Interaction; Molecular Models; Movement; Msec; Muscle, Skeletal; Muscle, Voluntary; Mutagenesis, Site-Directed; Mutation; NRVS-SYS; Na element; Nav1.2; Nervous System; Nervous System, Brain; Nervous system structure; Neurologic Body System; Neurologic Organ System; Nucleic Acid Biochemistry, Molecular Modeling; PKA; PKC; Palsy; Paralysed; Pathway interactions; Peripheral Nerves; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphotransferases; Plegia; Primary Hypokalemic Periodic Paralysis; Process; Property; Property, LOINC Axis 2; Protein Kinase; Protein Kinase A; Protein Kinase C; Protein Kinase Protein Phosphorylation; Protein Phosphorylation; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; R01 Mechanism; R01 Program; RPG; Regulation; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; SCN2A protein; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Skeletal Muscle Tissue; Skeletal muscle structure; Slide; Sodium; Sodium Channel; Staging; Structure; Subcellular Process; TXT; Targeted DNA Modification; Targeted Modification; Testing; Text; Therapeutic Hormone; Time; Toxin; Transphosphorylases; V (voltage); Widespread Disease; base; biological signal transduction; body movement; cAMP-Dependent Protein Kinases; chronic pain; chronic painful condition; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; constriction; cross-link; crosslink; disease/disorder; enzyme activity; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gene product; genome mutation; glycogen synthase a kinase; hydroxyalkyl protein kinase; information processing; membrane structure; millisecond; molecular modeling; mutant; na(v)1.2; paralysis; paralytic; pathway; phosphorylase b kinase kinase; protein structure; public health relevance; reconstitute; reconstitution; research study; response; sensor; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; voltage",Voltage Sensitive Sodium Channels in Brain," Project Narrative Sodium channels initiate electrical signals required for information processing in the nervous system, contraction of skeletal muscle and the heart, and secretion of hormones, and their normal function is impaired in periodic paralysis, epilepsy, chronic pain, and cardiac arrhythmia. This project will determine the molecular mechanism of sodium channel activation and inactivation, which are impaired in disease. This basic science information will be essential to understand and treat periodic paralysis, epilepsy, chronic pain, and cardiac arrhythmia.",15751,BPNS,Biophysics of Neural Systems Study Section,A2,29,341250,
7889739,R01,NS,2,,03/01/2010,02/28/2011,PA-07-070,2R01NS020013-25A2,,NINDS:323074;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"KESSLER, JOHN A;",1895003;,2R01NS020013,03/01/1983,02/28/2014,"1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1.beta.-D-Arabinofuranosylcytosine; 21+ years old; 3'5'-cyclic ester of AMP; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; ARA-cell; Ablation; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adult; Agonist; Alexan; Aminalon; Aminalone; Ammon Horn; Anatomic; Anatomical Sciences; Anatomy; Animals; Antimorphic mutation; Arabine; Arabinofuranosylcytosine; Arabinosylcytosine; Aracytidine; Aracytin; Aracytine; Attenuated; BMP4; Behavior; Behavioral; Biochemical; Bone Morphogenetic Proteins; Brain; Brain Part; Butanoic acid, 4-amino-; Cell Communication and Signaling; Cell Growth in Number; Cell Lineage; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cornu Ammonis; Cyclic AMP; Cytarabine; Cytarabinum; Cytarbel; Cytosar; Cytosar-U; CytosarU; Cytosine Arabinoside; Cytosine-.beta.-arabinoside; Dentate Fascia; Dentate Gyrus; Disease; Disorder; Disturbance in cognition; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Encephalon; Encephalons; Environment; Environmental Exposure; Erpalfa; Exercise; Exercise, Physical; Exposure to; Fascia Dentata; GABA; Goals; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Human, Adult; Impaired cognition; Individual; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Intraventricular Infusion; Lead; Learning; Link; Mammals, Mice; Mediating; Membrane; Memory; Methods and Techniques; Methods, Other; Mice; Mother Cells; Murine; Mus; Nervous; Nervous System Injuries; Nervous System Physiology; Nervous System Trauma; Nervous System damage; Nervous System, Brain; Neural Growth; Neural Stem Cell; Neurologic function; Neurological Damage; Neurological Injury; Neurological function; Neurological trauma; Neuronal Growth; Pathway interactions; Pb element; Performance; Process; Production; Progenitor Cells; Property; Property, LOINC Axis 2; Receptor Activation; Research; Role; Science of Anatomy; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stem cells; Structure of dentate gyrus; Tarabine PFS; Techniques; Testing; Therapeutic; Therapeutic Intervention; Transgenic Organisms; Trauma, Nervous System; Udicil; Ventricular; adenosine 3'5' monophosphate; adult human (21+); anatomy; biological signal transduction; bone morphogenetic protein receptors; cAMP; cognitive dysfunction; cognitive enhancement; cognitive function; cognitive loss; cognitively impaired; dentate gyrus; disease/disorder; environmental enrichment for laboratory animals; functional restoration; gamma-Aminobutyric Acid; granule cell; heavy metal Pb; heavy metal lead; hippocampal; in vivo; inhibitor; inhibitor/antagonist; intervention design; intervention therapy; interventional strategy; membrane structure; nerve stem cell; nervous system function; nestin; nestin protein; neural; neural progenitor cells; neurogenesis; neuron development; neuronal progenitor; neuronal progenitor cells; overexpression; paracrine; pathway; public health relevance; receptor, BMP; relating to nervous system; repair; repaired; response; restore function; restore functionality; restore lost function; self-renewal; social role; stem; therapy design; transgenic; treatment design",Mechanisms Governing Neuronal Development," Lay narrative In the adult brain new cells are made continuously in the hippocampus, a part of the brain that is critical for memory and other cognitive functions. Exercise or exposure of an animal to an enriched environment increases the rate of production of new cells and enhances cognitive performance. The goal of these studies is to understand how the environment influences the production of new cells in the hippocampus and ultimately to develop therapeutic techniques for restoring function in cognitively impaired individuals.",20013,NCF,Neurogenesis and Cell Fate Study Section,A2,25,323074,
7903849,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS022576-25,,NINDS:322656;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLESTON,UNITED STATES,PEDIATRICS,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SINGH, INDERJIT ;",1882295;,2R01NS022576,09/09/1985,01/31/2015,"0-11 years old; 1-Pentanamine, N-methyl-N-nitroso-; AMN; AMNTSAN; Abbreviations; Acetylcysteine; Acetylin; Addison disease-cerebral sclerosis syndrome; Addison disease-spastic paraplegia syndrome; Addison-Schilder syndrome; Adrenoleukodystrophy; Adrenomyeloneuropathy; Affect; Airbron; Allen & Hanburys Brand of Acetylcysteine; Apoptotic; Astrocytes; Astrocytus; Astroglia; Attenuated; Autopsy; Autoregulation; BGGI; Brain; Bristol-Myers Squibb Brand of Acetylcysteine; Bristol-Myers Squibb Brand of Acetylcysteine Sodium Salt; Broncholysin; Bronze Schilder disease; Brunac; CAAX geranylgeranyl transferase; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Signaling; Cells; Ceramide (lipids); Ceramides; Cerebrum; Child; Child Youth; Childhood; Children (0-21); Clinical; DHAP-acyltransferase; Demyelinating Diseases; Demyelinating Disorders; Development; Disease; Disorder; Drug usage; Dysfunction; EC 1.14.13.39; EC 2; EDRF Synthase; Encephalon; Encephalons; Endothelium-Derived Growth Factor Synthase; Event; Fabrol; Fanconi-Prader syndrome; Fibroblasts; Fluatox; Fluimucetin; Fluimucil; Fluprowit; Functional disorder; Funding; GGTI; GGTase-I; GalT-2; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Geranylgeranyl Transferase; Geranylgeranyltransferase Type I; Glucocerebrosides; Glucosyl Ceramides; Glucosylceramides; Goals; Guanylyl Cyclase-Activating Factor Synthase; Hereditary; Hereditary Disease; Homeostasis; Human; Human, Child; Human, General; IL-1 beta; IL-1-b; IL1-Beta; IL1B Protein; IL1F2; Inflammation Mediators; Inflammatory; Inflammatory Response; Inherited; Inpharzam Brand of Acetylcysteine; Interleukin 1, Beta Proprotein; Interleukin 1beta; Interleukin-1 beta; Intracellular Communication and Signaling; Knockout Mice; L-Alpha-acetamido-beta-mercaptopropionic Acid; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Laboratories; Lactosyl Ceramides; Lactosylceramides; Length of Life; Life; Life Expectancy; Link; Lipids; Longevity; Lorenzo's oil; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mercapturic Acid; Metabolic; Metabolic Diseases; Metabolic Disorder; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Disease; Muco Sanigen; Mucocedyl; Mucolator; Mucolyticum; Mucomyst; Mucosolvin; Mucret; Murine; Mus; Mutation; Myelin; N-Acetyl Cysteine; N-Acetyl-L-cysteine; N-Acetylcysteine; N-Amyl-N-Methylnitrosoamine; N-acetyl-3-mercaptoalanine; N-amyl-N-methylnitrosamine; N-nitrosomethylamylamine; NAC; NAC Zambon; NADPH-Diaphorase; NO Synthase; Necrosis; Necrotic; Neo-Fluimucil; Nervous System Diseases; Nervous System, Brain; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Optipect Hustengetr??nk; Oxidative Stress Induction; PGGT1B; PGGT1B gene; PPAR; Parvolex; Pathology; Pathway interactions; Patients; Peroxisomal Disorders; Peroxisome Proliferator-Activated Receptors; Physiological Homeostasis; Physiopathology; Preinterleukin 1 Beta; Process; Produpharm Lappe Brand of Acetylcysteine; Progress Reports; Proteins; Proteomics; Reporting; Reports, Progress; Research Design; Respaire; Roberts Brand of Acetylcysteine; Rodent; Rodentia; Rodentias; Role; Schilder-Addison Complex; Seminal; Siemerling-Creutzfeldt disease; Siemerling-Creutzfeldt syndrome; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Sphingomyelin Cholinephosphohydrolase; Sphingomyelin Cleaving Enzyme; Sphingomyelin Phosphodiesterase; Sphingomyelinase; Sphingomyelinase C; Sphingomyelins; Study Type; Techniques; Therapeutic; Thesaurismosis; Thiemann Brand of Acetylcysteine; Time; Tixair; Transferase; Treatment Efficacy; UDP Galactose; UDPGal; UPSA Brand of Acetylcysteine; Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-galactopyranosyl ester; Uridine Diphosphate Galactose; Uridine Diphosphogalactose; Uridine Pyrophosphogalactose; Very Long Chain Fatty Acid; X-Linked Adrenoleukodystrophy; Zambon Brand of Acetylcysteine; Zyma Brand of Acetylcysteine; acyl CoA-dihydroxyacetone phosphate acyltransferase; acyl coenzyme A-dihydroxyacetone phosphate acyltransferase; adrenocortical atrophy-cerebral sclerosis syndrome; adrenoleukomyeloneuropathy; adrenomyeloneuropathies; base; biological signal transduction; boys; brain cell; brain tissue; children; dihydroxyacetone-phosphate acyltransferase; dihydroxyacetonephosphate acyltransferase; disease/disorder; drug use; early childhood; effective therapy; fatty acid oxidation; gene function; gene product; genetic disorder; genome mutation; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; glycerone-phosphate O-acyltransferase; hereditary disorder; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; life span; lifespan; long chain fatty acid; melanodermic leukodystrophy; metabolism disorder; methyl-n-amylnitrosamine; movie; necrocytosis; necropsy; nervous system disorder; neuroinflammation; neurological disease; oxidation; pathophysiology; pathway; pediatric; peroxisome; postmortem; protein GGTase; protein geranylgeranyltransferase; public health relevance; ras protein GG transferase; ras protein geranylgeranyltransferase; response; social role; study design; therapeutic efficacy; therapeutically effective; tumor; youngster",Fatty Acid Oxidation in X-Linked Adrenoleukodystrophy," X-ALD, the most common genetic disorder of peroxisomes, affects boys in early childhood due to the pathognomonic accumulation of VLCFA. It is also known as Lorenzo's disease based on a movie called ""Lorenzo's Oil"" depicting the life of a child suffering from X-ALD. The mutation in ALD gene results in metabolic disease as excessive accumulation of VLCFA, which subsequently leads to neuroinflammatory disease, loss of oligodendrocytes/myelin and a shortened life span. Unfortunately, there is no effective therapy to control neurological disease. Children with X-ALD die within 1-3 years of onset of the neurological disease. The proposed studies are designed to delineate the molecular mechanisms of VLCFA derangement induced signaling that induces the inflammatory response in astrocytes and cell death in oligodendrocytes. Understanding these mechanisms is critical for the development of effective therapy for X-ALD.",22576,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,25,322656,
7782168,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS024760-22,,NINDS:402186;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,OTHER HEALTH PROFESSIONS,08,049435266,US,MA,02215,BOSTON UNIVERSITY,"BARBAS, HELEN ;",1862678;,2R01NS024760,07/01/1987,01/31/2015,"Address; Affect; Agents, Muscarinic; Anatomic; Anatomical Sciences; Anatomy; Anterior; Architecture; Area; Auditory; Auditory Cortex; Auditory Pathways; Auditory area; Auditory pathway structure; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Biological Models; Cell Communication and Signaling; Cell Signaling; Characteristics; Cholinergic Fibers; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Cognition; Cognitive; Complex; Data; Dendrites; Development; Disease; Disorder; Dorsal; Electron Microscope; Electrons; Emotional; Engineering / Architecture; Equilibrium; Foundations; Goals; Hallucinations; Hand; High Prevalence; Human; Human, General; Intracellular Communication and Signaling; Investigation; Kanner's Syndrome; Label; Lateral; Life; Light; Link; M2 receptor; Man (Taxonomy); Man, Modern; Medial; Mental disorders; Mental health disorders; Microscopic; Model System; Modeling; Models, Biologic; Muscarinic M2 Receptor; Muscarinics; Nature; Negative Beta Particle; Negatrons; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Pathways; Neurochemistry; Neurocyte; Neurologic; Neurological; Neurons; Noise; Output; Paradoxical Sleep; Parvalbumins; Pathway interactions; Pattern; Photoradiation; Physiologic; Physiological; Prefrontal Cortex; Process; Psychiatric Disease; Psychiatric Disorder; REM Sleep; Receptor Protein; Receptor, Muscarinic M2; Receptors, ACh; Receptors, Acetylcholine; Relative; Relative (related person); Rhombencephalic Sleep; Role; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Science of neurochemistry; Signal Transduction; Signal Transduction Systems; Signaling; Sleep, Fast-Wave; Sleep, REM; Specificity; Stimulus; Synapses; Synaptic; System; System, LOINC Axis 4; Tag; Testing; Therapeutic Intervention; Tracer; Translating; Translatings; Unspecified Mental Disorder; Work; anatomy; association cortex; auditory pathway; balance; balance function; base; biological signal transduction; brain tissue; calbindin; calbindin 2; calretinin; cingulate cortex; cognitive control; dementia praecox; density; design; designing; disease/disorder; dreaming sleep; excitatory neuron; executive control; executive function; experiment; experimental research; experimental study; flexibility; inhibitory neuron; intervention therapy; language translation; mental illness; molecular marker; neural; neural circuit; neural circuitry; neurochemistry; neuronal; neurotransmitter release; pathway; psychological disorder; public health relevance; rapid eye movement sleep; receptor; reconstruction; relating to nervous system; research study; response; schizophrenic; social role",Prefrontal Anatomic Pathways in Executive Control," Disruption in the balance of excitation and inhibition underlies the deficits in several neurologic and psychiatric diseases. Damage to the prefrontal cortex results in loss of the ability to filter out noise in auditory processing in humans. The dorsolateral prefrontal cortex, anterior cingulate and temporal auditory cortices are affected in schizophrenia, consistent with the auditory nature of hallucinations, distractibility and debilitating deficits in cognition. In autism, prefrontal and cingulate circuits involved in response inhibition are underactive and poorly synchronized. Investigation of the excitatory and inhibitory synaptic interactions within this integrated cortical circuit will have important implications for the development of therapeutic interventions for neurologic diseases, schizophrenia and autism.",24760,COG,Cognitive Neuroscience Study Section,,22,402186,
7890979,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS027910-20A2,,NINDS:334688;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,GALVESTON,UNITED STATES,NEUROSCIENCES,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"CARLTON, SUSAN M;",1908965;,2R01NS027910,01/01/1990,01/31/2014,"3'5'-cyclic ester of AMP; Absence of pain sensation; Absence of sensibility to pain; Acute; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Afferent Neurons; Agonist; Allergy; Attention; Axon; Behavior; Behavioral; Cell/Tissue, Immunohistochemistry; Cells; Chronic; Chung model; Closure by Ligation; Common Rat Strains; Coupling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Depression; Dorsal Root Ganglia; Down-Regulation; Down-Regulation (Physiology); Downregulation; Family; Feels no pain; Funding; Ganglia, Spinal; Glutamates; Heating; Hyperalgesia; Hyperalgesic Sensations; Hypersensitivity; IHC; INFLM; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inflammation; Inflammatory; L-Glutamate; Label; Ligation; Mammals, Rats; Mechanics; Mediating; Mental Depression; Metabotropic Glutamate Receptors; Modality; Modeling; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropathy; No sensitivity to pain; Nociception; Nociceptors; Opioid; PKA; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pathway interactions; Peripheral; Peripheral nerve injury; Physiologic; Physiological; Preparation; Protein Kinase A; Rat; Rattus; Receptor Protein; Receptors, Metabotropic Glutamate; Sensory Cell Afferent Neuron; Skin; Spinal Ganglia; Spinal Nerves; Spinal nerve structure; TRP channel; TRP protein; TRPV1; TRPV1 gene; Testing; Thermal Hyperalgesias; adenosine 3'5' monophosphate; allodynia; analgesia; base; cAMP; cAMP-Dependent Protein Kinases; chronic pain; chronic painful condition; digital; dorsal root ganglion; effective therapy; experiment; experimental research; experimental study; extracellular; gangliocyte; ganglion cell; hyperalgia; imaging; in vivo; inflammatory neuropathic pain; inflammatory pain; injured; nerve injury; neural injury; neuronal; neuropathic; neuropathic pain; nociceptive; novel; painful neuropathy; pathway; prevent; preventing; public health relevance; receptor; research study; response; sensory integration",Group III mGLURs: Mechanisms of Analgesia," Narrative This proposal will test the overall hypothesis that activation of peripheral Group III mGluRs is an effective treatment for nerve-injury and inflammatory pain. If our hypothesis is correct, we are defining novel peripheral targets that when activated reduce peripheral sensitization and thus have functional relevance in the control of pain of peripheral origin. This family of receptors will offer a large array of extracellular and intracellular targets that are different from those associated with Group II mGluRs, and, based on our preliminary data, will be important in the modulation of hyperalgesic states.",27910,ZRG1,Special Emphasis Panel,A2,20,334688,
7782230,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS028642-19,,NINDS:358987;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"NICHOLSON, CHARLES ;",1886570;,2R01NS028642,08/01/1990,01/31/2014,"21+ years old; Abscission; Accounting; Adult; Affect; Area; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain region; Carbohydrates; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Cerebellum; Cerebrospinal Fluid; Chemicals; Chronic Disease; Chronic Illness; Common Rat Strains; Complex; Computer Programs; Computer Simulation; Computer software; Computerized Models; Convection; Corpus Callosum; Corpus Callosums; Data; Development; Diffuse; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Drugs; ECM; Encephalon; Encephalons; Environment; Excision; Extirpation; Extracellular Matrix; Extracellular Space; FGF-2; FGF2; Fiber; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; GFAC; Generalized Growth; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF-2; Health; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Human, Adult; Idiopathic Parkinson Disease; Image; Imaging Procedures; Imaging Techniques; Injection of therapeutic agent; Injections; Intercellular Space; Intracellular Communication and Signaling; Investigation; Ions; Kinetic; Kinetics; Label; Lactoferrin; Lactotransferrin; Lewy Body Parkinson Disease; Literature; Magnetic Resonance; Mammals, Rats; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Molecular; Molecular Interaction; Molecular Layer; Molecular Layer of the Cerebellar Cortex; Nervous System, Brain; Neurosciences; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Pressure; Pressure- physical agent; Primary Parkinsonism; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prostate Epithelial Cell Growth Factor; Prostatropin; Proteins; Publishing; Rat; Rattus; Removal; Resolution; Role; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Slice; Software; Solutions; Source; Structure of molecular layer of cerebellar cortex; Supercomputing; Surgical Removal; Technics, Imaging; Techniques; Therapeutic; Therapeutic Agents; Time; Tissue Growth; Tissues; Viscosity; Work; adult human (21+); bFGF; base; biological signal transduction; brain cell; brain tissue; brain volume; chronic disease/disorder; chronic disorder; computational modeling; computational models; computational simulation; computer based models; computer program/software; computerized modeling; computerized simulation; diffusion tensor imaging; drug/agent; experiment; experimental research; experimental study; extracellular; fluorescent dye/probe; gene product; imaging; imaging modality; improved; in silico; insight; light scattering; neglect; neurotrophic factor; neurotrophin; neutrophin; ontogeny; optic imaging; optical imaging; pressure; programs; public health relevance; research study; resection; simulation; small molecule; social role; spinal fluid; substantia alba; tetramethylammonium; tool; trimethylaminomethane; vector; virtual simulation; white matter",Diffusion of Substances Through the Brain," Project Narrative Relevance for health:  This project focuses on the role of the extracellular matrix (an entanglement of long  complex molecules) in hindering diffusion of substances, including potential drugs, as they move in the  narrow spaces between brain cells.  Diffusion studies in fiber-rich brain regions will improve the basis for the  magnetic resonance technique of diffusion tensor imaging (DTI) and investigations on the diffusion and  binding of growth factors will facilitate therapeutic delivery to the brain.  Development of an imaging  technique for fluorescent molecules will provide a relatively inexpensive method for measuring diffusion of  drugs in brain tissue. ",28642,BPNS,Biophysics of Neural Systems Study Section,,19,358987,
7917766,R01,NS,2,,04/01/2010,03/31/2011,PA-07-070,2R01NS030989-18,,NINDS:369688;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"RUDY, BERNARDO ;",1871125;,2R01NS030989,08/01/1992,03/31/2015,"Action Potentials; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Behavior; Biological; Brain; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Cerebral cortex; Characteristics; Code; Coding System; Complex; Connector Neuron; Disease; Disorder; Drugs; Elements; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Fire - disasters; Fires; Frequencies (time pattern); Frequency; Funding; Generations; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Ion Channels, Potassium; K channel; Kanner's Syndrome; Knowledge; Mediating; Medication; Molecular; Mutation; Names; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Neurotransmitters; Pathogenesis; Pattern; Perception; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Population; Potassium Channel; Potentials, Synaptic; Process; Property; Property, LOINC Axis 2; Pyramidal Cells; Pyramidal neuron; Regulation; Role; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Seizures; Sensory; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Somatosensory Cortex; Specificity; Stimulus; Subcellular Process; Synapses; Synaptic; Synaptic Potentials; System; System, LOINC Axis 4; Testing; Time; Toxin; Training; biological signal transduction; cell type; dementia praecox; disease/disorder; drug/agent; epilepsia; epileptiform; epileptogenic; excitatory neuron; experiment; experimental research; experimental study; genome mutation; hippocampal pyramidal neuron; in vivo; information processing; neocortical; neuronal; neuronal excitability; public health relevance; research study; response; schizophrenic; social role; somesthetic sensory cortex; therapeutic target",Expression and function of K+ channel genes in brain," Narrative This project investigates the role of potassium channels in a subtype of neuron in the cerebral cortex known as the fast-spiking cell that is important in the generation of gamma rhythms, sensory perception and the pathogenesis of schizophrenia and autism.",30989,BPNS,Biophysics of Neural Systems Study Section,,18,369688,
7785262,R01,NS,2,,01/18/2010,12/31/2010,PA-07-070,2R01NS031231-15,,NINDS:325262;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BERKELEY,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"TANOUYE, MARK A;",1891942;,2R01NS031231,07/01/1994,12/31/2014,"Address; Adverse effects; Age; Anti-epileptic; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Antiproteases; Behavior; Binding; Binding (Molecular Function); Biological; Biophysics; Childhood; Disease; Disorder; Drosophila; Drosophila genus; Drug Evaluation, Preclinical; Drug Screening; Drugs; Endopeptidase Inhibitors; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Generalized; Epilepsy, Myoclonus; Epileptic Seizures; Epileptics; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Febrile Convulsion Seizure; Febrile Convulsions; Febrile Fit; Fever Convulsion; Fever Seizure; Flies; Fruit Fly, Drosophila; Gene Transfer; Generalized Epilepsy; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Goals; Human; Human Pathology; Human, General; Intractable Epilepsy; Lesion; Man (Taxonomy); Man, Modern; Maps; Medication; Modeling; Molecular; Molecular Interaction; Mutation; Myoclonic Epilepsies; Myoclonic Seizure Disorder; Neurologic; Neurological; Palsy; Paralysed; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plegia; Preclinical Drug Evaluation; Predisposition; Property; Property, LOINC Axis 2; Protease Antagonists; Protease Inhibitor; Proteinase Inhibitors; Pyrexial Convulsion; Pyrexial Seizure; Role; Seizure Disorder; Seizure Disorder, Generalized; Seizures; Seizures, Febrile; Serine Endopeptidase Inhibitors; Serine Protease Inhibitors; Serine Proteinase Antagonists; Serine Proteinase Inhibitors; Status Epilepticus; Status Epilepticus, Generalized; Suppressor Mutations; Susceptibility; Treatment Side Effects; base; disease/disorder; drug development; drug/agent; epilepsia; epileptiform; epileptogenic; fly; fruit fly; genome mutation; human disease; in vivo; infancy; infantile; interest; mutant; myoclonia epileptica; myoclonic seizure; new therapeutics; next generation therapeutics; novel therapeutics; paralysis; paralytic; pediatric; public health relevance; side effect; social role; therapy adverse effect; transfer of a gene; treatment adverse effect",Drosophila Bang-sensitive Paralytic Mutants," PROJECT NARRATIVE Neurological mutants in the fruit fly Drosophila are used to explore causes and cures for human epilepsy. In this proposal, we search for new anti-epileptic drugs with the potential for greater efficacy and fewer side effects than those presently available for epilepsy treatment.",31231,MNG,Molecular Neurogenetics Study Section,,15,325262,
7890189,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS033202-15A2,,NINDS:430305;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"GOMEZ, CHRISTOPHER MANUEL;",1873795;,2R01NS033202,04/01/1995,01/31/2015,"Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Axotomy; Bungarotoxins; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Caspase Inhibitor; Cell Death, Programmed; Cell Division Kinase 5; Cell Division Protein Kinase 5; Cell-Death Protease; Chinidin; Cholera Toxin B Subunit; Cholera Toxin Protomer B; Choleragenoid; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Color; Congenital Disorders; Cyclin-Dependent Kinase 5; Data; Defect; Desminase; Disease; Disease Pathway; Disease Progression; Disorder; Disorders, Congenital; Dysfunction; Effects, Longterm; Esteroproteases; Extremities; Fluoxetin; Fluoxetine; Frequencies (time pattern); Frequency; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Goals; ICE-like protease; Impairment; In Vitro; Ions; Laboratories; Lead; Limb structure; Limbs; Long-Term Effects; Mammals, Mice; Measures; Mediating; Messenger RNA; Metabolic; Mice; Mice, Transgenic; Modeling; Murine; Mus; Muscle; Muscle Fibers; Muscle Tissue; Mutation; Myasthenic Syndrome; Myoneural Junction; Myotubes; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Neural Transmission; Neuromuscular Diseases; Neuromuscular Junction; Non-Trunk; Papain-Like Cysteine Protease; Pathogenesis; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Phase; Physiopathology; Production; Proteases; Proteinase inhibitor, calpastatin; Proteinases; Proteins; Proteolytic Enzymes; Quinidine; RNA, Messenger; Receptor Gene; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Recombinants; Recycling; Relative; Relative (related person); Rhabdomyocyte; Role; Sarcoplasm; Screening procedure; Serine/Threonine-Protein Kinase PSSALRE; Serotonergic Agents; Serotonergic Drugs; Serotonin Agents; Serotonin Drugs; Signal Pathway; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Source; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Syndrome; TPKII Catalytic Subunit; Tau Protein Kinase II Catalytic Subunit; Testing; Therapeutic; Therapeutic Intervention; Toxin; Transfection; Transgenic Mice; Transgenic Organisms; VESCL; Vesicle; base; calpastatin; caspase; cdc2-related kinase PSSALRE; channel blockers; cholinergic; cystein protease; cystein proteinase; cysteine endopeptidase; disease/disorder; gene product; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; insight; intervention therapy; ion channel blocker; mRNA; model organism; mutant; myoneural disorder; neuromuscular; neuromuscular disorder; neuromuscular transmission; novel; pathophysiology; pathway; postsynaptic; presynaptic; public health relevance; receptor; receptor density; retrograde transport; screening; screenings; social role; synapse function; synaptic function; transgenic; uptake",Acetylcholine Receptor Genes in Slow-Channel Syndrome," 7. Project narrative: By assessing the relative contribution of different enzymatic and signaling pathways to neuromuscular weakness and synaptic degeneration in vivo, our studies of an animal model of SCS may lead to a practical strategy for therapeutic intervention with long-term benefit in SCS. These studies will also help identify pathways for postsynaptic influence on presynaptic function that may be relevant for neuromuscular disease and synaptic plasticity.",33202,ZRG1,Special Emphasis Panel,A2,15,430305,
7799467,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS033661-10A1,,NINDS:319375;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AUBURN UNIVERSITY,UNITED STATES,BIOLOGY,03,066470972,US,AL,36849,AUBURN UNIVERSITY AT AUBURN,"WOOTEN, MARIE W;",1879860;,2R01NS033661,08/01/1995,12/31/2013,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Acetylation; Adenosine Triphosphatase, Dynein; Adult; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Anxiety; Appearance; Autophagocytosis; Autophagosome; Axonal Transport; Axoplasmic Transport; BDNF; Behavior; Biochemical; Biochemistry; Blood Serum; Brain; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cell Communication and Signaling; Cell Signaling; Characteristics; Chemistry, Biological; Cornu Ammonis; Couples; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; Development; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Dysfunction; Encephalon; Encephalons; Excision; Exhibits; Extirpation; Family; Functional disorder; Gene Targeting; Genetic; Goals; HDAC6; HDAC6 gene; HMG-20; High Mobility Protein 20; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; Intracellular Communication and Signaling; JM21; KIAA0901; Kinesin; Knock-in; Knock-in Mouse; Knockout Mice; Knowledge; Laboratories; Learning; Lysosomes; MGC34632; MT-bound tau; Macropain; Macroxyproteinase; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; Methods; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microtubules; Mitochondria; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Motor; Multicatalytic Proteinase; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Growth Factor Receptors; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Neurotrophic Factor Receptor; Null Mouse; Oxidative Stress; PKC iota; Pathology; Pathway interactions; Phenotype; Phosphorylation; Physiology; Physiopathology; Polyubiquitin; Predisposition; Primary Senile Degenerative Dementia; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Binding Domain; Protein Binding Motif; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Trafficking; Protein Turnover; Protein-Protein Interaction Domain; Proteins; Proteosome; Receptor Protein; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Regulation; Regulatory Pathway; Removal; Resistance; Role; Scaffolding Protein; Serum; Short-Term Memory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Surgical Removal; Susceptibility; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Targetings, Gene; Time; Traffickings, Protein; Transport Proteins; Transporter Protein; Tubulin; Ubiquitilation; Ubiquitin; Ubiquitin, poly-; Ubiquitination; Ubiquitinoylation; VESCL; Vesicle; adult human (21+); atypical protein kinase C; autophagy; base; biological signal transduction; conformation; conformational state; dementia of the Alzheimer type; design; designing; dynein ATP phosphohydrolase (tubulin translocating); gain of function; gene product; hD6; hippocampal; in vivo; innovate; innovation; innovative; insight; insoluble aggregate; member; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; mitochondrial; mitochondrial dysfunction; mouse development; multicatalytic endopeptidase complex; mutant; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; neurotrophic factor; neurotrophin; neutrophin; new therapeutics; next generation therapeutics; novel; novel therapeutics; oxidative damage; pathophysiology; pathway; posttranslational modification of tau; primary degenerative dementia; protein aggregate; protein degradation; protein kinase C iota; protein transport; public health relevance; receptor; resection; resistant; scaffold; scaffolding; senile dementia of the Alzheimer type; social role; spatiotemporal; tau; tau Proteins; tau factor; tau phosphorylation; tau posttranslational modification; trafficking; ubiquination; ubiquitin conjugation; working memory",Mechanisms of Ubiquitin Trafficking in Neurons," Project Narrative This project will tease apart the function of the scaffolding protein p62. The innovative aspect of this project is that the role of p62 in trafficking of tau and other interacting proteins is largely undefined. P62 is a multifunctional protein involved in both of the two major protein degradation mechanisms, ubiquitin proteasome system and autophagy-lysosome pathway. The specific aims of this proposal are based upon the CENTRAL HYPOTHESIS that p62 is a novel shuttling factor that participates in the transport of proteins to the proteasome, autophagosome and removal of damaged mitochondria. Three synergistic but non-overlapping specific aims are proposed to further unravel the mechanistic details regarding the role of p62 in vivo. Aim 1 will illuminate the means by which p62 regulates clearance of aggregated proteins. Aim 2 will elucidate the mechanism whereby p62 regulates the trafficking and clearance of mitochondria. Aim 3 will define p62's role in mediating oxidative stress resistance. The results from this study will provide invaluable insights into the role of p62 in clearance of misfolded protein aggregates and neurodegeneration. These findings may provide an avenue to develop new therapeutics for the treatment of Alzheimer's disease as well as other neurodegenerative diseases, which possess disturbances in p62 expression as a component of their underlying pathophysiology.",33661,NOMD,Neural Oxidative Metabolism and Death Study Section,A1,10,319375,
7784774,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS034783-14A1,,NINDS:336546;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,GENETICS,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"FEHON, RICHARD G;",1908075;,2R01NS034783,01/01/1996,12/31/2014,"21+ years old; Adherens Junction; Adhering Junction; Adhesive Junction; Adult; Anchoring Junction; Apical; Attention; Benign; Biological Models; Body Tissues; Cancer Induction; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell membrane; Cell physiology; Cell surface; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Proliferation; Central Neurofibromatosis; Cytoplasm; Cytoplasmic Membrane; Deafness; Development; Disease; Disorder; Dmerlin; Drosophila; Drosophila genus; Drosophila merlin; EC 2.7; Epithelial Cells; Family; Fertility/Fertilization; Fertilization; Flies; Fruit Fly, Drosophila; Funding; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hereditary; Homolog; Homologous Gene; Homologue; Human; Human, Adult; Human, General; Individual; Inherited; Intracellular Communication and Signaling; Kinases; Laboratories; Lead; Life; Lipid Rafts, Cell Membrane; Mammalia; Mammalian Cell; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Microdomains; Merlin; Mice; Model System; Modeling; Models, Biologic; Moesin-Ezrin-Radixin-Like Protein; Molecular; Molecular Genetic; Molecular Genetics; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Multiple Neurofibromas; Murine; Mus; Mutation; NF2 Gene Product; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis 2; Neurofibromatosis 2 Gene Product; Neurofibromatosis II; Neurofibromatosis Syndrome; Neurofibromatosis Type 2 Protein; Neurofibromatosis, Acoustic, Bilateral; Neurofibromatosis, Central, NF 2; Neurofibromatosis, Central, NF2; Neurofibromatosis, Type 2; Neurofibromatosis, Type II; Neurofibromin 2; Neurons; Organism; Pathway interactions; Pb element; Phenotype; Phosphorylation; Phosphotransferases; Plasma Membrane; Protein Phosphorylation; Proteins; Receptor Protein; Recruitment Activity; Research; Role; Schwannomerlin; Schwannomin; Schwannomin Protein; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Sterility; Subcellular Process; Symptoms; Testing; Therapeutic Agents; Tissues; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transphosphorylases; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Type 2s, Neurofibromatosis; Work; acoustic neurofibromatosis; adult human (21+); bilateral vestibular Schwannoma; biological signal transduction; carcinogenesis; cell growth; design; designing; disease phenotype; disease/disorder; experiment; experimental research; experimental study; ezrin; fly; fruit fly; gene function; gene product; genome mutation; heavy metal Pb; heavy metal lead; insight; lipid raft; living system; member; membrane structure; membrane-organizing extension spike protein; merlin, Drosophila; moesin; mutant; neuronal; neuronal tumor; pathway; phosphoprotein p81; plasmalemma; positional cloning; protein 4.1; public health relevance; radixin; radixin protein; receptor; recruit; research study; reverse genetics; rho; social role; sterile; trafficking; transcription factor; tumor; tumor suppressor","Function of Merlin, a Drosophila NF2 Gene Homologue"," Project Narrative  These experiments in this proposal are designed to provide insights into the functions of Merlin (the Neurofibromaosis 2 tumor suppressor), Expanded and the Hippo pathway in regulating receptor trafficking and proliferation. In addition, the proposed experiments should lead to a better understanding of the cellular processes that establish specialized membrane domains in specialized cells such as neurons and epithelial cells. Finally, these studies should contribute to work on the mechanisms by which cellular interactions function to control cell growth and determine cell fate during development.",34783,NCF,Neurogenesis and Cell Fate Study Section,A1,14,336546,
7795622,R01,NS,2,,01/18/2010,11/30/2010,PA-07-070,2R01NS037766-11,,NINDS:322656;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLESTON,UNITED STATES,PEDIATRICS,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SINGH, INDERJIT ;",1882295;,2R01NS037766,08/01/1998,11/30/2014,"6-Methylcompactin; Affect; Agonist; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arm; Attenuated; Autoimmune; Autoimmune Process; Autoregulation; BDGF; BDNF; BGGI; BZS; Blood (Leukemia); Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Brain-Derived Neurotrophic Factor; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; CAAX geranylgeranyl transferase; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CDF; CNS Diseases; CNS Injury; CNS disorder; CNTF; COX-2; COX-2 protein; COX2; COX2 enzyme; Cell Communication and Signaling; Cell Culture System; Cell Signaling; Cells; Cells, CD4; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Central Nervous System Injury; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chronic; Ciliary Neuronotrophic Factor; Ciliary Neurotrophic Factor; Complement; Complement Proteins; Copaxone; Cyclo-Oxygenase-2; Cyclooxygenase; DHAP-acyltransferase; DIF; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Demyelinating Disease of Central Nervous System; Demyelinating Diseases; Demyelinating Disorder of Central Nervous System; Demyelinating Disorders; Demyelinations; Development; Disease; Disease model; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Encephalon; Encephalons; Event; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; FTI; Family; Farnesyl Transferase Inhibitor; Farnesyltransferase Inhibitors; GGDP; GGF Protein; GGPP cpd; GGTI; GGTase-I; GTP Phosphohydrolases; GTPases; Geranylgeranyl Transferase; Geranylgeranyltransferase Type I; Glia; Glial Cells; Glial Growth Factor; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HILDA; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hemato-Encephalic Barrier; Homeostasis; IFN; IGF-1; IGF-I; IGF-I-SmC; IGF1; Immune; Immune response; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Individual; Inducer Cells; Inflammatory; Injury of central nervous system; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Interferons; Interleukins; Intracellular Communication and Signaling; Kolliker's reticulum; LIF; LIF gene; Laboratories; Lecithinases; Lesion; Leukemias, General; Lipids; Lipoprotein LDL Receptors; Lovastatin; Low Density Lipoprotein Receptor; MAG Protein; MGC34632; MHAM; MMAC1; MOG glycoprotein; MS (Multiple Sclerosis); MS Lesions; Maintenance; Maintenances; Mediating; Medication; Medulla Spinalis; Mevinolin; Modeling; Monacolin K; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Multiple Sclerosis; Multiple Sclerosis Lesions; Myelin; Myelin Associated Glycoprotein; Myelin Basic Proteins; Myelin Proteins; Myeloencephalitis; Natural immunosuppression; Necrosis; Necrotic; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neuron Degeneration; Neurons; Non-neuronal cell; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; PCR; PDGF; PGG/HS; PGGT1B; PGGT1B gene; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PHS-2; PPAR; PTEN; PTEN gene; PTEN1; PTGS2; PTGS2 gene; Patients; Peroxisome Proliferator-Activated Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatase and Tensin Homolog; Phosphatases; Phosphohydrolases; Phospholipase; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiological Homeostasis; Platelet-Derived Growth Factor; Pleural Glycoproteins; Polymerase Chain Reaction; Property; Property, LOINC Axis 2; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Farnesyltransferase Inhibitors; Proteins; Proteolipids; RT-PCR; RTPCR; Receptor Activation; Receptors, LDL; Regulation; Relapse; Reporting; Reverse Transcriptase Polymerase Chain Reaction; Rho-associated kinase; Rho-kinase; Sclerosis, Disseminated; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Somatomedin C; Spinal Cord; T-Cells, Helper-Inducer; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TNF; TNF A; TNF gene; TNFSF2; Testing; Therapeutic; Time; Treatment Efficacy; Tumor Necrosis Factor Gene; Tumor Suppression; Tumor Suppression, Molecular; Upper arm; acyl CoA-dihydroxyacetone phosphate acyltransferase; acyl coenzyme A-dihydroxyacetone phosphate acyltransferase; autoimmune encephalomyelitis; base; biological signal transduction; brain growth promoting activity; brain trophin; brain-derived growth factor; central nervous system demyelinating disorder; central nervous system injury; cyclo-oxygenase II; cyclooxygenase 2; cytokine; design; designing; dihydroxyacetone-phosphate acyltransferase; dihydroxyacetonephosphate acyltransferase; diphosphoric acid, mono(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl) ester, (E,E,E)-; disability; disease/disorder; disorder model; drug candidate; drug/agent; effective therapy; farnesyl diphosphate; farnesyl pyrophosphate; farnesylpyrophosphate; gene product; geranylgeraniol diphosphate; geranylgeranyl pyrophosphate; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; glycerone-phosphate O-acyltransferase; guanosinetriphosphatase; hCOX-2; helper T cell; host response; immunoresponse; immunosuppression; improved; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insular sclerosis; isoprenoid; leukemia; mevacor; mevalonate; model organism; mouse model; myelin degeneration; myelin glycoprotein; myelin oligodendrocyte glycoprotein; nerve cement; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; neuroprotection; new therapeutic target; novel; oligodendrocyte-myelin glycoprotein; open label; precursor cell; progenitor; prostaglandin H synthase-2; protein GGTase; protein geranylgeranyltransferase; public health relevance; ras protein GG transferase; ras protein geranylgeranyltransferase; repair; repaired; reverse transcriptase PCR; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; tensin; tensin1; therapeutic efficacy; therapeutic target; therapeutically effective; tumor; unspecified interleukin",Cytokines in Glial Cells and EAE Brain," Narrative:  MS an autoimmune inflammatory demyelinating disease, affects approximately 400,000 individuals in US only and over 2.0 million individuals worldwide. In spite of the current therapeutics targeting immune response, the disease often progresses leading to neurodegeneration and thus physical disability reflecting the CNS injury. Therefore, the lack of effective treatments for MS represents a significant gap for treating the CNS disease. In addition to the anti-inflammatory and immunomodulatory properties the recently observed neuroprotective activities of statins identify novel aspect of their mechanisms for myelin repair by targeting the endogenous precursor cell. The proposed studies are innovative as they will improve our understanding of mechanisms for pharmacological enhancement of the potential of CNS endogenous cells to treat CNS disease (myelin repair) in MS. These studies will identify therapeutic targets for induction of myelin repair in MS and these findings should be applicable to other related neurodegenerative diseases.",37766,ZRG1,Special Emphasis Panel,,11,322656,
7783455,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS037822-09A1,,NINDS:394964;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLUMBUS,UNITED STATES,OTHER HEALTH PROFESSIONS,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"BUFORD, JOHN A (contact);JAKEMAN, LYN B;",1891185 (contact);1913527;,2R01NS037822,07/30/1999,01/31/2015,"Affect; Apoplexy; Area; Arm; Bilateral; Bone structure of cranium; Brain Part; Brain Stem; Brainstem; Cells; Cerebral Stroke; Cerebral cortex; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cervical Portion of Spinal Cord; Cervical Spinal Cord; Cervical spinal cord structure; Complement; Complement Proteins; Confocal Microscopy; Contralateral; Cranium; Data; Dorsal; Electric Stimulation; Electrical Stimulation; Exertion; Extremities; Future; Investigation; Ipsilateral; Isometric Exercise; Isometrics; Knowledge; Label; Laboratories; Left; Light; Limb structure; Limbs; Location; Measures; Medulla Spinalis; Membrum superius; Microscopy, Confocal; Monkeys; Motor; Motor Cortex; Movement; Muscle-Setting Exercise; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Non-Trunk; Operating System; Output; Pathway interactions; Pattern; Photoradiation; Physiologic; Physiological; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Prevalence; Recovery; Response to stimulus physiology; Reticular Formation; Science of neurophysiology; Side; Skull; Sorting - Cell Movement; Source; Spinal Cord; Static Exercise; Stimulus; Stroke; Structure; Study Subject; System; System, LOINC Axis 4; Tag; Testing; Time; Tracer; Training; Upper Extremity; Upper Limb; Upper arm; Upper limb movement; Vascular Accident, Brain; WGA-HRP; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; awake; base; body movement; brain attack; cerebral vascular accident; cranium; experiment; experimental research; experimental study; improved; injured; motor control; neural; neuronal; neurophysiology; pathway; public health relevance; relating to nervous system; research study; sorting; stimulus/response; stroke; stroke recovery; stroke rehab; stroke rehabilitation; theories",Reticulospinal Control of Reaching," When people have a stroke, the part of the brain usually injured is the cerebral cortex, just under the skull. This usually impairs control of movement on one side of the body. This project studies how the cerebral cortex cooperates with a deep structure called the reticular formation that can also control movement, but is rarely affected by stroke. There is a long held theory that the reticular formation helps take over after stroke, but this has never been directly studied. This project will define how the cortex and reticular formation normally cooperate as a preliminary step to future studies where the potential for these systems to cooperate after stroke can be studied and expanded to improve recovery.",37822,SMI,Sensorimotor Integration Study Section,A1,9,394964,
7889784,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS038486-11A1,,NINDS:417594;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"NIKOLOV, DIMITAR B;",2802522;,2R01NS038486,02/01/1999,01/31/2014,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 21+ years old; 3-D structure; 3-dimensional structure; 3D structure; AL-1; AL-1 Protein; Adult; Affinity Chromatography; Architecture; Assay; Binding; Binding (Molecular Function); Binding Site Domain; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biophysics; Biotin; Cek7 Ligand; Cek7 RPTK Ligand; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell surface; CellLine; Cells; Cellular Migration; Chemicals; Chromatography, Affinity; Cleaved cell; Closure by Ligation; Complex; Coupled; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; DNA Molecular Biology; DSS1; Deleted In Split-Hand/Split-Foot 1 Region; Deleted in Split-Hand/Split-Foot 1 Region Gene; Development; EC 2.7; ECD; ELF-1 Protein, Mammalian; EPH; EPLG6 Gene Product; Efbn2 Gene Product; Engineering; Engineering / Architecture; Engineerings; Eph Family Receptors; Eph Ligand Family 1 Protein, Mammalian; Eph Receptor Ligands; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Ephrin-A2; Ephrin-A5; Ephrin-B2; Ephrins; Eplg5 Gene Product; Eplg5 Protein; Esteroproteases; Event; Family; Fluorescence; Future; Human, Adult; Intracellular Communication and Signaling; Investigation; Kinases; Kinetic; Kinetics; LERK-5 Gene Product; LERK-5 Protein; LERK-6 Protein; LERK-7 Protein; Length; Leukemia, Lymphocytic; Ligand Binding; Ligand Binding Domain; Ligands; Ligation; Link; Lymphoblastic Leukemia; Lymphoid Leukemia; Mediating; Membrane Proteins; Membrane-Associated Proteins; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods; Methods and Techniques; Methods, Other; Moab, Clinical Treatment; Molecular; Molecular Biology; Molecular Interaction; Monoclonal Antibodies; Motility; Motility, Cellular; Nervous System Physiology; Neurologic function; Neurological function; PTK Receptors; Peptidases; Peptide Hydrolases; Peptides; Phosphotransferases; Play; Position; Positioning Attribute; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteases; Protein Biochemistry; Protein/Amino Acid Biochemistry; Proteinases; Proteins; Proteolytic Enzymes; RAGS Protein; REK7 Ligand AL-1; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptors, Eph Family; Recombinants; Relative; Relative (related person); Repulsive Axon Guidance Signal Protein; Research; Role; SEM1; SHFD1; SHFDG1; SHFM1; SHFM1 gene; SHSF1; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Specificity; Structure; Surface Proteins; System; System, LOINC Axis 4; TM Domain; Techniques; Thermodynamic; Thermodynamics; Time; Transmembrane Domain; Transmembrane Receptor Protein Tyrosine Kinase; Transmembrane Region; Transphosphorylases; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Phosphorylation; Vascular System; Vitamin H; X Ray Crystallographies; X-Ray Crystallography; adult human (21+); affinity purification; analytical ultracentrifugation; axon growth cone guidance; axon guidance; base; biological signal transduction; cell motility; cleaved; coenzyme R; cultured cell line; experiment; experimental research; experimental study; extracellular; falls; gene product; insight; light scattering; lymphatic leukemia; lymphogenous leukemia; metalloproteinase (general); milligram; nervous system function; novel; polypeptide; programs; public health relevance; receptor; research study; social role; three dimensional structure; tool",Structural Study of Eph Receptors and Ephrins," ! Principal Investigator/Program Director (Last, first, middle): Nikolov, Dimitar B.  Eph receptors represent the largest subfamily of receptor tyrosine kinases. The Ephs and their ligands, the Ephrins, are predominantly expressed in the developing and adult nervous and vascular systems, playing important roles in axon guidance and cell migration. Eph receptors are unique among other receptor kinases in that they fall into two subclasses with distinct ligand specificities, and in that they can also function as ligands activating bi-directional signaling. Understanding the mechanism of Eph/ephrin signaling and its role during development requires a detailed structural and biophysical characterization of the Eph receptors, the ephrins, and their interaction. We use X-ray crystallography combined with other biophysical techniques to study how these molecules recognize and interact with each other. The specific aims of our proposed investigations are: : 1. Structural characterization of full Eph ectodomains alone and in complex with ephrins; 2. Structural and biophysical characterization of the Eph/ephrin/ADAM interactions and cleavage; 3. Production, structural and functional characterization of full-length (transmembrane) Eph receptors. + PHS 398/2590 (Rev. 05/01) Page ___ Continuation Format Page +",38486,MSFC,Macromolecular Structure and Function C Study Section,A1,11,417594,
7780737,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS038684-10A1,,NINDS:358750;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,ANESTHESIOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KOEHLER, RAYMOND C;",1897246;,2R01NS038684,01/01/2000,01/31/2015,"Acute; Adverse effects; Animals; Antioxidants; Apoplexy; Arteries; Arterioles; Behavior; Biochemical; Blood Plasma; Blood Vessels; Blood capillaries; Blood erythrocyte; Blood flow; Blood normocyte; Body Tissues; Bovine Species; Brain; Capillaries; Capillary; Capillary, Unspecified; Cattle; Cause of Death; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Clotting; Coagulation; Coagulation Process; Common Rat Strains; Data; Disease; Disorder; Distal; Dose; Drugs; EC 1.14.13.39; EDRF Synthase; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelin; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Endothelium-Derived Vasoconstrictor Factors; Engineering; Engineerings; Enzymes; Erythrocyte Volume, Packed; Erythrocytes; Erythrocytic; Experimental Models; Experimental Models, Other; Extravasation; Female; Filament; Gender; Generations; Goals; Guanylyl Cyclase-Activating Factor Synthase; Hct; Hematocrit; Hematocrit procedure; Hemoglobin; Hepatic Proliferation Inhibitor; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Infarction; Infusion; Infusion procedures; Injury; Investigation; Ischemia; Ischemic Stroke; Knowledge; L arginine amidinohydrolase; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Leakage; Link; Liquid substance; Liver Immunoregulatory Protein; Liver-Derived Inhibitory Protein; Macrogols; Mammals, Mice; Mammals, Rats; Marrow erythrocyte; Medication; Membrane; Mercaptans; Mercapto Compounds; Mice; Middle Cerebral Artery Occlusion; Modeling; Models, Experimental; Molecular Weight; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Murine; Mus; NADPH-Diaphorase; NO Synthase; Nervous System, Brain; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrite Reductase; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nitrous acid, sodium salt; O element; O2 element; Occlusion, Middle Cerebral Artery; Outcome; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen; PEG; Packed Red-Cell Volume; Perfusion; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polymers; Polyoxyethylenes; Pressure; Pressure- physical agent; Production; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Rat; Rattus; Recombinants; Recycling; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reticuloendothelial System; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Societies; Sodium Nitrite; Solutions; Spillage; Stroke; Structure of arteriole; Sulfhydryl Compounds; Superoxide Anion; Superoxide Radical; Superoxides; Surface; Survivors; TRNSF; Testing; Therapeutic; Thiols; Tissues; Transfusion; Translating; Translatings; Translations; Treatment Side Effects; Vascular Accident, Brain; Vascular constriction (function); Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasopressor Agents; Vasorelaxation; Viscosity; Work; anti-oxidant; arginase; arginine amidinase; arteriole; base; blood corpuscles; bovid; bovine; brain attack; canavanase; capillary; catalase; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; cerebrovascular; cow; cross-link; crosslink; design; designing; disability; disease/disorder; drug/agent; electron acceptor; endothelial cell derived relaxing factor; feeding; fluid; improved; infarct; inhibitor; inhibitor/antagonist; injured; language translation; liquid; male; membrane structure; mimetics; molecular size; neurobehavior; next generation; novel; oxidant stress; polymerization; pressure; public health relevance; scale up; shear stress; side effect; social role; stroke; sulfhydryl group; therapy adverse effect; treatment adverse effect; vascular; vascular bed; vasopressor",Cell Free O2 Carriers: Cerebrovascular Control and Stroke," NARRATIVE Stroke is the third leading cause of death, and the disabilities that remain in survivors place a major burden on society. In experimental models of stroke, we will investigate the use of chemically modified hemoglobin molecules, which are endowed with unique physical and antioxidant properties, as transfusion fluids that enable more oxygen to be delivered to the injured brain without adding to the oxidant stress of the stroke. We will also investigate drugs that can dilate arteries and permit more blood flow and oxygen to be delivered selectively to the injured brain when administered together with the hemoglobin solution and thereby enhance rescue of tissue from ischemic stroke.",38684,BINP,Brain Injury and Neurovascular Pathologies Study Section,A1,10,358750,
7807873,R01,NS,2,,01/18/2010,12/31/2010,PA-07-070,2R01NS038696-09A2,,NINDS:355469;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,ANATOMY/CELL BIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"SCHAUWECKER, PAULA E;",1963555;,2R01NS038696,04/01/1999,12/31/2014,"3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-; Acquired brain injury; Allelism Test; Ammon Horn; Anti-epileptogenic; Antiepileptogenic; Apoplexy; Bio-Informatics; Bioinformatics; Body Tissues; Brain Injuries; C57BL/6 Mouse; Candidate Disease Gene; Candidate Gene; Cell Death; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chromosome 18; Chromosome Mapping; Chromosomes, Human, Pair 18; Code; Coding System; Complementation Test; Complex; Congenic Strain; Convulsions; Cornu Ammonis; Critical Paths; Critical Pathways; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Digenic Acid; Disease; Disorder; Drugs; Dysfunction; Epilepsies, Partial; Epilepsy; Epilepsy, Focal; Epilepsy, Localization-Related; Epileptic Seizures; Epileptics; Excitatory Neurotoxins; Excitotoxin; Exclusion; Exhibits; Exons; Expression Profiling; Expression Signature; FVB Mouse; FVB/N Mouse; Focal Seizure Disorder; Functional disorder; Funding; Gene Expression; Gene Expression Profile; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene variant; Genes; Genetic; Genetic Complementation Test; Genetic Diversity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetics, Gene Mapping; Genome; Genome Scan; Genomics; Genotype; Grant; Hippocampus; Hippocampus (Brain); Housing; Human; Human, General; Hypoxia; Hypoxic; Inbred Strains Mice; Inherited Predisposition; Inherited Susceptibility; Kainic Acid; Link; Linkage Mapping; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medication; Methods; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mice, Transgenic; Modeling; Modification; Molecular; Molecular Analysis; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Monitor; Mouse Strains; Murine; Mus; Mutant Strains Mice; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neurons; Oxygen Deficiency; Partial Epilepsies; Pathogenesis; Pathology; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Play; Predisposition; Predisposition gene; Programs (PT); Programs [Publication Type]; QTL; Quantitative Trait Loci; RNA Splicing; Recovery; Recurrence; Recurrent; Resistance; Resolution; Role; Seizure Disorder; Seizure Disorder, Partial; Seizures; Splicing; Stroke; Structural Protein; Susceptibility; Susceptibility Gene; Technology; Testing; Therapeutic Intervention; Time; Tissues; Trans Test; Transcript; Transgenic Mice; Transgenic Organisms; Variant; Variation; Variation (Genetics); Vascular Accident, Brain; allelic variant; base; brain attack; brain damage; brain lesion (from injury); candidate identification; cerebral vascular accident; clinical data repository; clinical data warehouse; comparative; congenic; data repository; design; designing; disease/disorder; drug/agent; epilepsia; epileptiform; epileptogenic; excitotoxicity; experiment; experimental research; experimental study; gain of function; gene expression signature; gene interaction; genetic etiology; genetic mapping; genetic mechanism of disease; genetic vulnerability; genome sequencing; genome, mouse; hippocampal; in vivo; insight; intervention therapy; molecuar profile; molecular signature; mouse genome; mouse model; mouse mutant; necrocytosis; neurodegenerative illness; neuronal; new therapeutic target; overexpression; pathophysiology; pathway; predisposing gene; prevent; preventing; programs; prospective; public health relevance; relational database; research study; resistance mechanism; resistant; resistant mechanism; response; social role; standard care; stem; stressor; stroke; trait; transcriptome; transgenic",MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH, Project Narrative Our studies will identify and characterize the genes responsible for modulating susceptibility to seizure- induced excitotoxic cell death in murine strains. Identification of epilepsy modifier genes will provide insight into the pathogenesis of epilepsy and aid in the development of novel therapeutic targets for the treatment of human epilepsy.,38696,MNG,Molecular Neurogenetics Study Section,A2,9,355469,
7790206,R01,NS,2,,01/15/2010,11/30/2010,PA-07-070,2R01NS038992-09,,NINDS:336875;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NEUROSURGERY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"CEPEDA, CARLOS T;MATHERN, GARY W (contact);",1866758 (contact);9700290;,2R01NS038992,07/01/1999,11/30/2013,"0-11 years old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Abnormal Cell; Acute; Affect; Agonist; Aminalon; Aminalone; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Barbiturates; Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-; Body Tissues; Brain; Bumetanide; Bumex; Butanoic Acids; Butanoic acid, 4-amino-; Butyric Acids; Causality; Cell Death, Programmed; Cells; Cellular Morphology; Cerebral cortex; Cerebrum; Characteristics; Child; Child Youth; Childhood; Children (0-21); Chloride; Chloride Ion; Chlorides; Cl- element; Clinical; Cognitive; Connector Neuron; Cortical Dysplasia; Cortical Malformation; Development; Developmental Process; Drug Combinations; Dysfunction; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Epileptogenesis; Etiology; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Figs; Figs - dietary; Frequencies (time pattern); Frequency; Functional disorder; GABA; Generations; Glia; Glial Cells; Glutamates; Goals; Histopathology; Human; Human, Child; Human, General; Infant; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Knowledge; Kolliker's reticulum; L-Glutamate; Link; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane; Molecular Layer; Molecular Layer of the Cerebellar Cortex; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurological; Neurons; Neurophysiology / Electrophysiology; Non-neuronal cell; Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Pathogenesis; Pathway interactions; Patients; Physiopathology; Property; Property, LOINC Axis 2; Public Health; Pyramidal neuron; RAFT1 protein, human; RAPT1 protein, human; Radial; Rapamune; Rapamycin; Rapamycin Target Protein; Receptor Protein; Refractory; Regimen; Roche Brand of Bumetanide; Science of neurosurgery; Seizure Disorder; Seizures; Sirolimus; Structure of molecular layer of cerebellar cortex; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; Synaptic Membranes; Testing; Tissues; Zeugmatography; barbiturate; barbituric acid salt; base; brain tissue; cell morphology; children; density; disability; disease causation; disease etiology; disease/disorder etiology; disorder etiology; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; gray matter; hippocampal pyramidal neuron; human FRAP1 protein; mTOR; membrane structure; model organism; nerve cement; neuronal; neurosurgery; pathophysiology; pathway; pediatric; public health medicine (field); public health relevance; rapamycin and FKBP12 target 1 protein, human; receptor; research study; social; substantia grisea; surgery; synapse formation; synaptogenesis; youngster",Pathophysiology of Developing Dysplastic Human Cortex," PROJECT NARRATIVE The most common cause of epilepsy in children undergoing neurosurgery is cortical malformations of the brain. We propose that malformed brains do not fully develop and retain immature features. We will test this hypothesis by using clinical, anatomical and electrophysiological approaches to examine brain tissue removed at surgery to understand the causes of epilepsy and alleviate seizures in children.",38992,ANIE,Acute Neural Injury and Epilepsy Study Section,,9,336875,
7804295,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS039110-10,,NINDS:351690;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,VETERINARY SCIENCES,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"BUCKMASTER, PAUL SCOTT;",1880265;,2R01NS039110,04/01/2000,12/31/2014,"2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-; Affect; Ammon Horn; Anti-epileptogenic; Antiepileptogenic; Axon; Basket Cell; Body Tissues; Cell Body; Common Rat Strains; Connector Neuron; Cornu Ammonis; Coupling; Cyclic Somatostatin; Data; Defect; Dendrites; Dentate Fascia; Dentate Gyrus; Docking; Dysfunction; Electron Microscopy; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Epileptogenesis; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FLR; FRAP1 protein, human; Failure (biologic function); Fascia Dentata; Functional disorder; Funding; Future; GFP; Goals; Green Fluorescent Proteins; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; Gyrus Dentatus; Hilar; Hippocampus; Hippocampus (Brain); Individual; Inhibitory Synapse; Injury; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Killings; Label; Mammals, Mice; Mammals, Rats; Measures; Methods; Mice; Modeling; Molecular Layer; Molecular Layer of the Cerebellar Cortex; Murine; Mus; Myoepithelial cell; Nerve Cells; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neurons; Pathway interactions; Patients; Physiopathology; Pilocarpine; Probability; Publishing; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Rat; Rattus; Reporting; Research; Role; SRIH; SRIH-14; Seizure Disorder; Seizures; Sirolimus; Site; Slice; Somatostatin; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; Status Epilepticus; Status Epilepticus, Generalized; Structure of dentate gyrus; Structure of molecular layer of cerebellar cortex; Synapses; Synaptic; Synaptic Transmission; Temporal Lobe Epilepsy; Testing; Time; Tissues; VESCL; Vesicle; base; biocytin; biotinyl L lysine; cell body (neuron); dentate gyrus; effective therapy; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; failure; granule cell; growth hormone release inhibiting factor; hippocampal; human FRAP1 protein; innovate; innovation; innovative; mTOR; mTOR Inhibitor; mTOR Signaling Pathway; mossy fiber; neural cell body; neuronal; neuronal cell body; novel; pathophysiology; pathway; prevent; preventing; public health relevance; rapamycin and FKBP12 target 1 protein, human; repair; repaired; research study; social role; soma; synapse formation; synaptogenesis",Interneuron based mechanisms of temporal lobe epilepsy, Many patients with epilepsy have uncontrolled spontaneous seizures that initiate in or near hippocampal dentate gyrus. Seizures might be caused by inadequate inhibition. This project will investigate in detail how and why inhibition is abnormal in dentate gyrus of a rat model of epilepsy.,39110,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,10,351690,
7886787,R01,NS,2,,04/01/2010,03/31/2011,PA-07-070,2R01NS039579-10,,NINDS:351455;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,NEUROLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"HUGUENARD, JOHN R.;PRINCE, DAVID ALLAN (contact);",1866730 (contact);1894920;,2R01NS039579,12/01/1999,03/31/2014,"ANOVA; Acquired brain injury; Affect; Agonist; Analysis of Variance; Anti-epileptic; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Approaches to prevention; Axon Terminals; Bathing; Baths; Body Tissues; Brain; Brain Diseases; Brain Disorders; Brain Injuries; Butanoic Acids; Butyric Acids; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cerebral cortex; Characteristics; Chemicals; Chemosensitization; Chemosensitization/Potentiation; Chronic; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complement; Complement Proteins; Connector Neuron; Conotoxin; Coupled; Cyclic Somatostatin; Data; Dendrites; Dependence; Disturbance in cognition; Dysfunction; Electromagnetic, Laser; Encephalon; Encephalon Diseases; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Epileptogenesis; FLR; Failure (biologic function); Functional disorder; Genetically Engineered Mouse; Glutamates; Goals; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; Health; Heterogeneity; Human; Human, General; Impaired cognition; In Vitro; Injury; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Ion Channels, Calcium; Knowledge; L-Glutamate; Label; Lasers; Lead; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Methods and Techniques; Methods, Other; Mice; Minority; Modeling; Murine; Mus; Nature; Neocortex; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; Neuropeptide Tyrosine; Neuropeptides; Output; Parvalbumins; Pb element; Perfusion; Physiopathology; Population; Potentiation; Presynaptic Receptors; Presynaptic Terminals; Prevention approach; Probability; Process; Property; Property, LOINC Axis 2; Pyramidal Cells; Radiation, Laser; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, Presynaptic; Regulation; Role; SRIH; SRIH-14; SUBGP; Scanning; Seizure Disorder; Seizures; Slice; Somatosensory Cortex; Somatostatin; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; Subcellular Process; Subgroup; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; System; System, LOINC Axis 4; Techniques; Testing; Thalamic structure; Thalamus; Tissues; Toxin; Transgenic Organisms; Transmission; VDCC; Variance Analyses; Variant; Variation; Voltage-Dependent Calcium Channels; brain damage; brain lesion (from injury); cell type; channel blockers; cognitive dysfunction; cognitive loss; cognitively impaired; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; failure; growth hormone release inhibiting factor; heavy metal Pb; heavy metal lead; homotypical cortex; immunoreactivity; improved; information processing; inhibitory neuron; injured; isocortex; man; man's; neocortical; neopallium; neuronal; neuropeptide Y; patch clamp; pathophysiology; postsynaptic; presynaptic; prevent; preventing; public health relevance; receptor; research study; response; social role; somesthetic sensory cortex; thalamic; transgenic; transmission process",Modulation of Neocortical Interneuronal Function," Project narrative: Epilepsy following brain injury is a major health problem. The mechanisms that lead from injury to epilepsy in man are poorly understood, however loss of the ability to inhibit or ""quiet"" nerve cells with the chemical messenger, GABA, is one key underlying factor. The proposed experiments will use a model of posttraumatic epilepsy to better understand how nerve cells regulate GABA release in normal and injured brain, what might go wrong after brain injury, and how that knowledge might be used to improve approaches for prevention and treatment of epilepsy.",39579,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,10,351455,
7809266,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS040480-09,,NINDS:321563;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AUGUSTA,UNITED STATES,NEUROLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"MEI, LIN ;",8134896;,2R01NS040480,01/11/2000,12/31/2014,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; APC - Adenomatous Polyposis Coli; ARIA; Abbreviations; Acetylcholine; Acetylcholine Receptor Inducing Activity; Actins; Address; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Agrin; Assay; Attenuated; Axon; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Breast Cancer Cell Differentiation Factor P45; CAAX geranylgeranyl transferase; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium/calmodulin-dependent protein kinase; Cell Communication and Signaling; Cell Signaling; Cells; Central Nervous System; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Congenital Myasthenic Syndromes; Cysteine-Rich Domain; Diagnostic; Dimerization; Dysfunction; EC 2.7; ELISA; Ensure; Enzyme-Linked Immunosorbent Assay; Enzymes; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Familial Adenomatous Polyposis Syndrome; Family; Functional disorder; Funding; GGF; GGF2; GGTase-I; Gated Ion Channel; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Intervention; Geranylgeranyl Transferase; Geranylgeranyltransferase Type I; Glycogen Synthase Kinases; Goals; HGL; HRGA; Hand; Hereditary Adenomatous Polyposis Coli; Heregulin Gene; Human; Human, General; In Vitro; Integral Membrane Protein; Intervention, Genetic; Intracellular Communication and Signaling; Intrinsic Membrane Protein; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; Kinases; L-Tyrosine; LEF Transcription Factor; Laboratories; Ligands; Link; Lipoprotein LDL Receptors; Low Density Lipoprotein Receptor; Lymphoid Enhancer Factor; MAP Kinase 8; MAP Kinase 8 Gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mitogen-Activated Protein Kinase 8; Molecular; Molecular Biology, Gene Therapy; Molecular Interaction; Motor; Motor Cell; Motor Neurons; Muscle Cell Contraction; Muscle Cells; Muscle Cells, Mature; Muscle Contraction; Muscle Fibers; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Dystrophies; Myasthenia Gravis, Congenital; Myasthenic Syndromes, Congenital; Myocytes; Myodystrophica; Myodystrophy; Myoneural Junction; Myotubes; NDF; NDF Protein; NEU Differentiation Factor Gene; NRG1; NRG1 Gene Product; NRG1 Protein; NRG1 gene; Nerve; Nerve Impulse Transmission; Nerve Transmission; Nervous; Nervous System, CNS; Neuraxis; Neuregulin 1; Neuromuscular Junction; Neuronal Transmission; PRKM8; PTK Receptors; Phosphotransferases; Physiopathology; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Postsynaptic Membrane; Protein Dimerization; Proteins; RTK; Receptor Protein-Tyrosine Kinases; Receptors, ACh; Receptors, Acetylcholine; Receptors, LDL; Regulation; Relative; Relative (related person); Rhabdomyocyte; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SMDF; Sensory And Motor Neuron-Derived Factor; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Specificity; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Synapses; Synaptic; T Cell Factor; TCF Transcription Factor; TYR; Therapy, DNA; Transmembrane Protein; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Tyrosine; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Phosphorylation; Tyrosine, L-isomer; adapter protein; biological signal transduction; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; cholinergic synapse; experiment; experimental research; experimental study; extracellular; familial adenomatous polyposis; familial polyposis; gene product; gene therapy; genetic therapy; genome-wide; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; in vivo; jun-NH2-Terminal Kinase; member; microtubule associated protein 2 kinase; motoneuron; neurotransmission; novel; para-Tyrosine; pathophysiology; postsynaptic; protein GGTase; protein geranylgeranyltransferase; protein kinase II; public health relevance; ras protein GG transferase; ras protein geranylgeranyltransferase; reconstitute; reconstitution; research study; response; skeletal; stress-activated protein kinase 1; tool",Activation and regulation of MuSK,  The long-term goal of our laboratory is to understand molecular mechanisms underlying the formation and maintenance of synapses. This proposal is to investigate how MuSK is regulated by two newly identified proteins: LRP4 and Wnt11. A combination of in vitro and in vivo experiments will be performed. Results will provide a better understanding of cellular as well as molecular mechanisms of mammalian NMJ formation. They will also contribute to a better understanding of pathophysiology of muscular dystrophy and to developing strategies of gene therapy and of diagnostic tools.,40480,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,9,321563,
7884658,R01,NS,2,,01/19/2010,12/31/2010,PA-07-070,2R01NS040511-11,,NINDS:451126;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ROWITCH, DAVID H;",1866016;,2R01NS040511,08/01/2000,12/31/2014,"ASV; ATP-protein phosphotransferase; Address; Affinity; Antibodies; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Avian Sarcoma; Avian Sarcoma Viruses; Biochemical; Biological; Cancer of Brain; Cell Cycle; Cell Division Cycle; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Cells; Chromatin; Complex; DNA Sequence; Demyelinating Diseases; Demyelinating Disorders; Developmental Biology; Drug Evaluation, Preclinical; Drug Screening; Embryo; Embryonic; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Gene Targeting; Gene Transcription; Generalized Growth; Genetic; Genetic Transcription; Growth; Infection; L-Serine; Laboratories; Libraries; Light; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Malignant Tumor of the Brain; Malignant neoplasm of brain; Mammals, Mice; Maps; Medulla Spinalis; Methods; Mice; Mice, Mutant Strains; Mice, Transgenic; Modeling; Molecular; Mother Cells; Motor Cell; Motor Neurons; Murine; Mus; Mutant Strains Mice; Myelin; Myelopathy, Traumatic; Neural Stem Cell; Neural tube; Nucleus; Olig2 protein; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Outcome; Patients; Pattern; Pattern Formation; Phospho-Specific Antibodies; Phosphopeptide-Specific Antibodies; Phosphorylation; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Photoradiation; Precipitation; Preclinical Drug Evaluation; Process; Progenitor Cells; Protein Kinase; Protein Phosphorylation; Proteins; Protocol; Protocols documentation; RNA Expression; Reagent; Research; Role; Sarcoma, Avian; Serine; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stem cells; System; System, LOINC Axis 4; Targetings, Gene; Testing; Tissue Growth; Transcription; Transcription, Genetic; Transgenic Mice; Work; base; cultured cell line; daughter cell; dimer; expression vector; gene function; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; in vivo; kinase inhibitor; mimetics; motoneuron; motor neuron development; mouse model; mouse mutant; mutant; myelination; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; novel; olg-2 gene product; olig2 gene product; oligo2 gene product; oligodendrocyte lineage; oligodendrocyte lineage gene product 2; ontogeny; phosphorylase b kinase kinase; progenitor; protein protein interaction; public health relevance; scaffold; scaffolding; self-renewal; shRNA; short hairpin RNA; single molecule; small hairpin RNA; small molecule; social role; tool; transcription factor; vector",Oligodendrocyte Lineage Gene Function in the CNS," PROJECT NARRATIVE Relevance: The proposed work may shed light on molecular mechanisms that regulate neural progenitors in malignant gliomas, spinal cord injury and demyelinating diseases.",40511,ZRG1,Special Emphasis Panel,,11,451126,
7777949,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS040750-10,,NINDS:326047;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MORRISON, SEAN J;",6481232;,2R01NS040750,02/01/2001,12/31/2014,"Alleles; Allelomorphs; Anaplastic; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Claw; Collection; Common Rat Strains; Cytofluorometry, Flow; Data; Defect; Development; Disease; Disorder; Dorsal; Embryo; Embryonic; Enteral; Enteric; Enteric Nervous System; Exhibits; Fetal Development; Fetal development of the mammalian embryo or fetus; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Funding; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Family; Gene Products, RNA; Gene Targeting; Genes; Genes, LacZ; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gestation; Glia; Glial Cell Tumors; Glial Cells; Glial Neoplasm; Glial Tumor; Glioma; Intracellular Communication and Signaling; Kolliker's reticulum; L-Leucine; LacZ; LacZ Genes; Leucine; Leucine, L-Isomer; Mammals, Mice; Mammals, Rats; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Microfluorometry, Flow; Molecular Interaction; Mother Cells; Murine; Mus; Mutant Strains Mice; Mutate; Mutation; Myxoid cyst; Neoplasms of Neuroglia; Nerve Cells; Nerve Unit; Neural Cell; Neural Crest; Neural Crest Cell; Neural Ganglion; Neural tube; Neurilemma Cell; Neurilemmal Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neuroglial Neoplasm; Neuroglial Tumor; Neurons; Non-neuronal cell; Peripheral Nerves; Peripheral Nervous System; Phenotype; Play; Pregnancy; Profilings, Gene Expression; Progenitor Cells; Proteins; RNA; RNA, Non-Polyadenylated; Rat; Rattus; Receptor Protein; Receptor Signaling; Regulation; Ribonucleic Acid; Role; Schwann Cells; Sciatic Nerve; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Structure of sciatic nerve; Subcellular Process; Targetings, Gene; Techniques; Testing; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Tumors of Neuroglia; Undifferentiated; base; biological signal transduction; disease/disorder; fetal; flow cytophotometry; gene product; genome mutation; gliogenesis; in vivo; insight; member; migration; mouse mutant; myelination; nerve cement; nervous system development; neuronal; novel; progenitor; public health relevance; receptor; sciatic nerve; self-renewal; social role",Stem Cells in Peripheral Nervous System Development, 7. Project Narrative The purpose of this project is to study the mechanisms that regulate peripheral nervous system (PNS) development. We hypothesize that we have identified a protein that regulates the expansion of neural crest stem cells and their differentiation into glial cells in the developing PNS. By better understanding these mechanisms we will gain new insights into how the PNS forms and what goes wrong in the context of disease.,40750,NCF,Neurogenesis and Cell Fate Study Section,,10,326047,
7788001,R01,NS,2,,03/01/2010,02/28/2011,PA-07-070,2R01NS041537-09,,NINDS:258433;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,NEUROSCIENCES,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GLEESON, JOSEPH G;",6628876;,2R01NS041537,04/01/2001,02/28/2015,"Address; Brain; C-terminal; Cell Body; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Centrosome; Cerebral Palsy; Clinical; Complementary DNA; Cortical Malformation; Coupling; DNA, Complementary; Defect; Dephosphorylation; Development; EC 2.7; Electroporation; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Event; Family; Female; Gene Family; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; IQ Deficit; Immigrations; In Vitro; In-Migration; Intracellular Communication and Signaling; Kinases; Knock-in; Knock-in Mouse; Knock-out; Knockout; L-Serine; L-Threonine; Lead; Life; Link; MAP; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediation; Mental Retardation; Methods; Mice; Micro-tubule; Microtubule-Associated Proteins; Microtubules; Miller-Dieker Syndrome; Miller-Dieker lissencephaly syndrome; Molecular; Motility; Motility, Cellular; Movement; Murine; Mus; Mutate; Mutation; N-terminal; NH2-terminal; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurites; Neurocognitive Deficit; Neurocyte; Neuronal Migration Disorder; Neurons; Nuclear; Patients; Pb element; Phase; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physical condensation; Play; Point Mutation; Process; Protein Dephosphorylation; Protein Phosphorylation; Proteins; Regulation; Role; Seizure Disorder; Seizures; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Syndrome; Testing; Threonine; Transphosphorylases; Travel; Work; Wrist; adapter protein; adult stem cell; agyria syndrome; agyria-pachygyria syndrome; base; biological signal transduction; body movement; cDNA; cell body (neuron); cell imaging; cell motility; cellular imaging; classical lissencephaly; condensation; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; hydrocephalic lissencephaly, is a major feature of; in utero; in vivo; infancy; infantile; knock-down; lissencephaly; male; migration; migration disorder; mouse model; neocortical; neurabin II; neural; neural cell body; neuron development; neuronal; neuronal cell body; public health relevance; relating to nervous system; research study; social role; soma; spinophilin",Doublecortin in Neuronal Migration," 7. Project Narrative The doublecortin gene family plays critical roles in brain development, resulting in severe forms of epilepsy and mental retardation when mutated. We will study the signaling mechanisms of the doublecortin gene family, in order to understand the basis of these human diseases.",41537,DBD,Developmental Brain Disorders Study Section,,9,258433,
7887976,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS041564-09,,NINDS:324844;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MADISON,UNITED STATES,ANATOMY/CELL BIOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"GOMEZ, TIMOTHY M.;",1922743;,2R01NS041564,09/20/2000,01/31/2014,"Actins; Adhesion Plaques; Adhesions; Affect; Axon; BDNF; Behavioral; Biological Models; Biological Neural Networks; Biosensor; Brachydanio rerio; Brain; Brain-Derived Neurotrophic Factor; CAP20 protein; CDK-Interacting Protein 1; CDK2-associated protein 20 kDa; CDKN1 protein; CDKN1A; CDKN1A Protein; CIP-1 Protein; Cdk2 inhibitor protein; Cell Adhesion; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cells; Cellular Adhesion; Cellular Matrix; Cellular Migration; Chimera Protein; Chimeric Proteins; Cip1 protein; Cognition Disorders; Complexes, Macromolecular; Cues; Cyclin-Dependent Kinase Inhibitor 1A; Cytoskeletal System; Cytoskeleton; Danio rerio; Data; Defect; Dendrites; Detection; Development; EC 2.7; ECM; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Environment; Event; Extracellular Matrix; Extracellular Matrix Proteins; Extracellular Matrix, Integrins; FAK; FAK1; Family member; Fibroblasts; Filopodia; Focal Adhesion Kinase 1; Focal Adhesions; Focal Contacts; Fusion Protein; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GFAC; GTP GDP exchange factor; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glia; Glial Cells; Growth; Growth Agents; Growth Cones; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Human; Human, General; In Vitro; Individual; Integrins; Intracellular Communication and Signaling; Intracellular Second Messengers; Kinases; Knock-out; Knockout; Kolliker's reticulum; L-tyrosine, dihydrogen phosphate (ester); Life; Ligands; Link; Location; MDA 6; MGC34632; Macromolecular Complexes; Man (Taxonomy); Man, Modern; Measures; Membrane; Mental Retardation; Mental disorders; Mental health disorders; Model System; Models, Biologic; Molecular; Morphogenesis; Motility; Motility, Cellular; Mutation; NRVS-SYS; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Development; Neurites; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Organ System; Neurons; Non-neuronal cell; P21; PTK2; PTK2 Protein Tyrosine Kinase 2; Phosphotransferases; Phosphotyrosine; Pic-1 protein (cyclin); Process; Proteins; Psychiatric Disease; Psychiatric Disorder; Receptor Protein; Regulation; Research; Role; Second Messenger Systems; Second Messengers; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Structure; Synapses; Synaptic; Testing; Therapeutic Intervention; Tissue Growth; Transphosphorylases; Tyrosine-O-phosphate; Unspecified Mental Disorder; WAF-1 Protein; WAF1 CIP1; WAF1 protein; Xenopus; Zebra Danio; Zebra Fish; Zebrafish; axon growth cone guidance; axon guidance; base; biological signal transduction; cdn1 protein; cell motility; cognitive disease; cognitive disorder; cognitive function; cyclin-dependent kinase Inhibitor p21; design; designing; endogenous substrate pp120; exchange factor; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; gene product; genome mutation; in vivo; intervention therapy; intracellular skeleton; knock-down; loss of function; mda-6 protein; membrane structure; mental illness; migration; mutant; nerve cement; nervous system development; neural network; neurodevelopment; neuronal; oncoprotein p21; ontogeny; p125(FAK); p125FAK; p21 activated kinase; p21 cell cycle regulator; p21 cyclin kinase inhibitor; p21(cip1); p21(waf1-cip1); p21-WAF1; paxillin; polymerization; pp125(FAK); pp125FAK; protein p21; psychological disorder; public health relevance; receptor; response; second messenger; senescent cell-derived inhibitor protein 1; sensor (biological); social role",Regulation of Axon Guidance by Second Messengers," The development of a functional nervous system requires accurate guidance of axons and dendrites to their target locations and establishment of synaptic connections. This proposal is focused on understanding how axon guidance cues regulate axon outgrowth by modulating integrin-dependent adhesions. As a number of cognitive disorders result from improper axon pathfinding, understanding the molecular basis for normal neural development is essential for designing therapeutic interventions.",41564,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,9,324844,
7781699,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS043466-06A2,,NINDS:334853;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLOTTESVILLE,UNITED STATES,NEUROSCIENCES,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"ZEITLIN, SCOTT O;",1933873;,2R01NS043466,04/01/2002,01/31/2014,"20q; Adenosine Triphosphatase, Dynein; Affect; Alleles; Allelomorphs; Antigenic Determinants; Antimorphic mutation; Autophagocytosis; Autophagosome; Behavioral; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Biochemical; Body Tissues; Brain; Cell Culture Techniques; Cells; Cessation of life; Chromosome 20 Distal Arm; Chromosome 20 Long Arm; Complex; Corpus Striatum; Corpus striatum structure; Data; Death; Degenerative Diseases, Nervous System; Degenerative Hereditary Disorders, Nervous System; Degenerative Neurologic Disorders; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Encephalon; Encephalons; Epitopes; Exhibits; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; HD protein, human; Heredodegenerative Disorders, Nervous System; Human; Human, General; Huntingtin; Huntingtin Protein; Huntingtin protein, human; Huntington Chorea; Huntington Disease; Huntington disease protein, human; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntington's disease gene product; Huntingtons Disease; IT15 protein, human; In Vitro; Knock-out; Knockout; Knockout Mice; Length; Length of Life; Ligand Binding Protein; Longevity; Lysosomes; MGC[{..}]3310; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Minus End of the Microtubule; Molecular Interaction; Movement; Murine; Mus; Mutant Strains Mice; Mutation; Nerve Cells; Nerve Unit; Nervous System Diseases, Degenerative, Hereditary; Nervous System Heredodegenerative Disorders; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Diseases, Hereditary; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Nongrowing End of the Microtubule; Null Mouse; Organelles; Pathogenesis; Pathway interactions; Phenotype; Play; Poly Q; Polyubiquitin; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Research; Resistance; Role; Stretching; Striate Body; Striatum; Symptoms; TNF Receptor-Associated Factor 6 Gene; TRAF6; TRAF6 gene; Testing; Therapeutic; Tissues; Trinucleotide Repeats; Triplet Repeats; Ubiquitin, poly-; Work; autophagy; base; body movement; codon reiteration; design; designing; disease phenotype; disease/disorder; dynein ATP phosphohydrolase (tubulin translocating); experiment; experimental research; experimental study; gain of function; gain of function mutation; gene product; genome mutation; human Huntingtin protein; insoluble aggregate; life span; lifespan; loss of function; mouse model; mouse mutant; mutant; nestin; nestin protein; neurodegenerative illness; neuronal; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathway; poly(glutamine); polyQ; polyglutamine; protein aggregate; public health relevance; research study; resistant; retrograde transport; social role; striatal; treatment strategy",Loss-of-function mechanisms in Huntington's Disease,"  Huntington's disease (HD) is a hereditary neurodegenerative disease affecting ~1 in 10,000 people that is caused by a mutation in the protein huntingtin (htt). There is currently no cure for this disorder, and once symptoms are detected, the disease progresses over 10-20 years and ends inevitably in death. We propose experiments that will help us to understand how the mutation affects htt normal function so that we can discover new therapeutic strategies based on restoring htt function in people affected with HD.",43466,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,A2,6,334853,
7783334,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS044266-06A1,,NINDS:613815;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,NEUROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GROSSMAN, MURRAY ;",1886377;,2R01NS044266,03/01/2002,01/31/2015,"21+ years old; Accuracy of Diagnosis; Adopted; Adult; Anterior; Atrophic; Atrophy; Attention; Beer; Binding; Binding (Molecular Function); Biological Neural Networks; Brain; Cognitive; Communication; Comprehension; Corticodentatonigral degeneration with neuronal achromasia; Data; Decision Making; Disease; Disorder; Dorsal; Eating; Elements; Encephalon; Encephalons; Food Intake; Frontotemporal Lobar Degenerations; Functional Magnetic Resonance Imaging; Funding; Grant; Human, Adult; Inferior; Intraparietal Sulcus; Knowledge; Language; Linguistic; Linguistics; Link; Lobar Degenerations, Frontotemporal; Logic; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Medial; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Molecular Interaction; Monitor; NMR Imaging; NMR Tomography; Nerve Degeneration; Nervous; Nervous System, Brain; Neuron Degeneration; Non-aphasic; Nuclear Magnetic Resonance Imaging; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Pathology; Patients; Performance; Prefrontal Cortex; Probability; Process; Research Resources; Resources; Role; Speech; Structure of intraparietal sulcus; Time; Work; Zeugmatography; adult human (21+); base; boys; cognitive neuroscience; cortico-basal degeneration; corticobasal degeneration; diagnostic accuracy; disease/disorder; drinking; fMRI; frontal cortex; frontal lobe; improved; insight; intraparietal sulcus; morphometry; neural; neural degeneration; neural mechanism; neural network; neurodegeneration; neuroeconomics; neuromechanism; neuronal degeneration; novel; parietal cortex; professor; public health relevance; relating to nervous system; social role",Neural Basis of Generalized Quantifiers," In this competing renewal, we propose to show that the quantity component of number knowledge contributes to the representation of number-based quantifiers like ""at least half"" and ""most."" Studies of patients with corticobasal degeneration and fMRI activation studies of healthy controls will relate this to inferior parietal cortex. This collaborates with another, pragmatic component of quantifiers, and studies of patients with frontotemporal lobar degeneration and fMRI studies of healthy adults will relate this to prefrontal cortex. Quantifiers can be ambiguous, and we will adopt a neuroeconomic approach to decision-making to help understand quantifier interpretation. This process will be mediated by a large-scale neural network including several frontal and parietal regions. The proposed work will provide important insights into the cognitive neuroscience of language and number while improving diagnostic accuracy in an elusive neurodegenerative condition.",44266,LCOM,Language and Communication Study Section,A1,6,613815,
7918711,R01,NS,2,,02/01/2010,01/31/2011,PA-07-282,2R01NS045954-07A2,,NINDS:341469;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LEXINGTON,UNITED STATES,PHYSIOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"TAYLOR, BRADLEY K;",1883189;,2R01NS045954,09/10/2002,01/31/2014,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; Accounting; Activation, Gene; Address; Adverse effects; Agonist; Allergy; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Behavior; Behavioral; Binding; Binding (Molecular Function); Biochemical; Body Tissues; Care, Health; Cell Communication and Signaling; Cell Signaling; Cells; Coupling; Data; Development; Dorsal Horn Cells; Doxycycline; Drugs; Euler-Gaddum Substance P; Freund's Adjuvant; Freund's Complete Adjuvant; Funding; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Activation; Gene Inactivation; Gene Silencing; Genes; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Healthcare; Hypersensitivity; INFLM; Immunostimulants, adjuvants, Freund's; Inflammation; Inflammatory; Injury; Interruption; Intracellular Communication and Signaling; Maintenance; Maintenances; Measures; Mechanics; Mediating; Medication; Medulla Spinalis; Methods; Mice, Transgenic; Modeling; Molecular Interaction; NK1R; NPY gene; NPY-Y1 receptor; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neurocyte; Neuronal Transmission; Neurons; Neurons, Dorsal Horn; Neurons, Posterior Horn; Neuropeptide Y Receptor; Neurotoxins; Nociception; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Posterior Horn Cells; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Receptor Activation; Receptor Protein; Receptor Signaling; SP(1-11); Science of neurophysiology; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Speed; Speed (motion); Spinal; Spinal Cord; Substance P; System; System, LOINC Axis 4; TAC1R; TACR1; TACR1 gene; Testing; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Time; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Transgenic Mice; Transgenic Organisms; Transmission; Treatment Side Effects; Vibramycin; Work; allodynia; alpha-6-Deoxyoxytetracycline; analgesia; biological signal transduction; chronic pain; chronic painful condition; dorsal horn; drug/agent; genetic promoter element; in vivo; inflammatory neuropathic pain; mouse model; nerve injury; neural injury; neurokinin 1; neuronal; neuropathic pain; neuropeptide Y-Y1 receptor; neuropeptide YY1 receptor; neurophysiology; neurotoxicant; neurotransmission; nociceptive; painful neuropathy; postsynaptic; public health relevance; receptor; receptor coupling; receptor expression; sham surgery; side effect; therapy adverse effect; trans acting factor (genetic); transgenic; transmission process; treatment adverse effect",Neuropeptidergic Inhibition of Spinal Pain Transmission," PUBLIC HEALTH RELEVANCE STATEMENT Chronic pain management is a major scientific and health care challenge, as current analgesic drugs rarely provide sufficient efficacy in the absence of serious side effects. Our preliminary data suggest that new drugs acting at the neuropeptide Y receptor system in the spinal cord will overcome these problems, but further studies are required to determine how NPY works. Such studies are critical not only to determine whether NPY is a natural long-lasting analgesic that reduces the duration of pain, but also to harness its therapeutic potential towards the development of new analgesic drugs.",45954,ZRG1,Special Emphasis Panel,A2,7,341469,
7879133,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS046456-06,,NINDS:541105;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"MUELLER, ULRICH ;",7120288;,2R01NS046456,07/01/2003,03/31/2015,"Adhesion Molecule; Adhesives; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Antimorphic mutation; Architecture; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Binding; Binding (Molecular Function); Binding Site Domain; Binding Sites; Cadherins; Cell Adhesion Molecules; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Surface Receptors; Cell-to-Cell Interaction; Cells; Cellular Migration; Combining Site; Cortical Cell Layer; Data; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Electroporation; Engineering / Architecture; Epilepsy; Epileptic Seizures; Epileptics; Event; Family; Family member; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetics, in situ Hybridization; Genetics-Mutagenesis; Glia; Glial Cells; Goals; Homo; Human; Human, General; Immigrations; In Situ Hybridization; In-Migration; Intracellular Communication and Signaling; Kanner's Syndrome; Knowledge; Kolliker's reticulum; Laboratories; Lead; Ligand Binding; Ligand Binding Domain; Link; Liver Cell Adhesion Molecules; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mental Retardation; Messenger RNA; Mice; Molecular Biology, Mutagenesis; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Mutagenesis; Mutation; Neocortex; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurological Disorders; Neurons; Non-neuronal cell; PTP-1B protein; PTP1B enzyme; Pathway interactions; Pattern; Pb element; Polymorphism (Genetics); Polymorphism, Genetic; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Proteins; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Radial; Reactive Site; Receptor Protein; Receptors, Cell Surface; Recombinants; Role; Route; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Staging; Structure; TM Domain; Technology; Testing; Time; Transmembrane Domain; Transmembrane Region; Tyrosine Phosphorylation; Ventricular; autism spectrum disorder; base; biological signal transduction; cell adhesion protein; cell motility; cell type; dementia of the Alzheimer type; dementia praecox; disease/disorder; epilepsia; epileptiform; epileptogenic; gene product; genome mutation; heavy metal Pb; heavy metal lead; homotypical cortex; in situ Hybridization Staining Method; in utero; insight; isocortex; liver cell adhesion molecule; mRNA; member; migration; neocortical; neopallium; nerve cement; nervous system disorder; neurological disease; neuronal; pathway; polymorphism; postnatal; primary degenerative dementia; protein tyrosine phosphatase 1B; public health relevance; receptor; schizophrenic; senile dementia of the Alzheimer type; shRNA; short hairpin RNA; small hairpin RNA; social role",Cell adhesion molecules in CNS development," General Statement Disruption of the laminar architecture of the neocortex is associated with more than 25 neurological disorders, including epilepsy, schizophrenia, autism and mental retardation. Cortical layers are established by the migration of neurons from proliferative zones into the developing cortical wall and their incorporation into neuronal circuits. We propose here to identify and study cell surface receptors that control neuronal migration during the formation of cortical cell layers. We anticipate that knowledge of how these receptors control migration will be relevant for understanding the mechanisms leading to pathological changes associated with several neurological disorders.",46456,NCF,Neurogenesis and Cell Fate Study Section,,6,541105,
7784088,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS046668-06A1,,NINDS:335599;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AURORA,UNITED STATES,PEDIATRICS,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"APPEL, BRUCE H;",1875550;,2R01NS046668,07/01/2003,12/31/2014,"Affect; Automobile Driving; Axon; Biological Models; Brachydanio rerio; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Lineage; Cell Signaling; Cell division; Cells; Central Nervous System; Complex; Connector Neuron; Danio rerio; Defect; Development; Disease; Disorder; Drivings, Automobile; EC 2.7; Embryo; Embryonic; Ensure; FLR; Failure (biologic function); Funding; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic analyses; Genetic defect; Glia; Glial Cells; Goals; Homolog; Homologous Gene; Homologue; Image; Individual; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Investigation; Kinases; Knowledge; Kolliker's reticulum; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Medulla Spinalis; Methods; Model System; Modeling; Models, Biologic; Molecular; Mother Cells; Motor Cell; Motor Neurons; Mutate; Mutation; Myelin; NRVS-SYS; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, CNS; Nervous system structure; Neural Cell; Neural Growth; Neural Stem Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurological Damage; Neurological Injury; Neurological trauma; Neuronal Growth; Neuronal Transmission; Neurons; Non-neuronal cell; Notch and Wnt Signaling Pathway; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Organism; Pattern; Phenotype; Phosphorylation; Phosphotransferases; Population; Presenilin action in Notch and Wnt signaling; Process; Production; Progenitor Cells; Protein Phosphorylation; Role; SCF Ubiquitin Ligase; SKP Cullin F-Box Protein Ligases; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Staging; Stem cells; Testing; Time; Transphosphorylases; Trauma, Nervous System; Zebra Danio; Zebra Fish; Zebrafish; atypical protein kinase C; biological signal transduction; cell behavior; cell type; design; designing; developmental disease/disorder; developmental disorder; disease/disorder; driving; effective therapy; failure; gene function; genetic analysis; genome mutation; gliogenesis; imaging; in vivo; intervention design; living system; motoneuron; mutant; myelination; nerve cement; nerve stem cell; neural precursor cell; neural progenitor cells; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; neurotransmission; notch; notch protein; notch receptors; oligodendrocyte lineage; postnatal; prevent; preventing; public health relevance; self-renewal; social role; therapy design; time use; treatment design",Genetic Analysis of Oligodendrocyte Specification," Project Narrative Failure to form or maintain myelin, the insulation that permits rapid transmission of nerve impulses, results in profound neurological deficits. This project seeks to identify the genes required for formation of myelinating cells in the developing nervous system, which could enhance the design of therapies to promote myelination and remyelination.",46668,NCF,Neurogenesis and Cell Fate Study Section,A1,6,335599,
7784106,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS046750-05A2,,NINDS:479595;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,PHYSIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"HOLMES, TODD C;",1908484;,2R01NS046750,07/01/2003,12/31/2013,"Action Potentials; Address; Animals; Arousal; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Biology; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Circadian Rhythms; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Coupled; Coupling; Darkness; Darknesses; Data; Disease; Disorder; Diurnal Rhythm; Drosophila; Drosophila genus; Editorial Comment; Editorial Comment (PT); Encephalon; Encephalons; Exhibits; Flies; Fruit Fly, Drosophila; Future; Genetic; Goals; Image; Intracellular Communication and Signaling; Knowledge; Laboratory Study; Lateral; Light; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Mediating; Mediation; Methods; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptides; Nyctohemeral Rhythm; Operation; Operative Procedures; Operative Surgical Procedures; Pace Stimulators; Pacemakers; Paper; Pattern; Photoradiation; Physiologic; Physiological; Poly Q; Preparation; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Publications; Published Comment; Publishing; Research; Resolution; Rest; Scientific Publication; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Disorders; Sleep Wake Cycle; Specificity; Stimulators, Electrical, Pace; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; System; System, LOINC Axis 4; Time; Twenty-Four Hour Rhythm; Viewpoint; Viewpoint (PT); Wakefulness; Wakefulnesses; Work; base; behavioral control; biological signal transduction; blue light receptor cryptochrome; circadian; circadian clock; circadian pacemaker; circadian process; comparative; cost; cost effective; cryptochrome; daily biorhythm; day length; disease/disorder; diurnal variation; environmental change; falls; fly; fruit fly; gene product; imaging; improved; insight; neural circuit; neural circuitry; neuronal; novel; onset of sleep; poly(glutamine); polyQ; polyglutamine; public health relevance; response; sleep onset; sleep problem; surgery; tool",Electrical Signaling in a Circadian Pacemaker Circuit," Project Narrative Sleep disruption can occur due to aberrant activity of arousal neurons which delay sleep onset and lower sleep maintenance, thus understanding the interactions between arousal, circadian and sleep circuits is of critical importance. Our recent work identifies a group of light-driven neurons that interface circadian and arousal circuits in Drosophila and share many physiological characteristics with mammalian sleep regulating arousal neurons. We propose to determine the functional properties of these arousal neurons and their modulation of the circadian circuit.",46750,BRS,Biological Rhythms and Sleep Study Section,A2,5,479595,
7887812,R01,NS,2,,02/01/2010,12/31/2010,PA-07-070,2R01NS047533-06A2,,NINDS:320469;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,NEUROSCIENCES,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"WILSON, SCOTT MICHAEL;",7631764;,2R01NS047533,01/01/2004,12/31/2014,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; ALS; APF-1; ATP-Dependent Proteolysis Factor 1; Acute; Address; Affect; Age; Amyotrophic Lateral Sclerosis; Aran-Duchenne disease; Axon; Axon Terminals; Behavioral; Biochemistry; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cessation of life; Chemistry, Biological; Chronic; Cruveilhier disease; Cues; Data; Death; Defect; Deubiquitinating Enzyme; Deubiquitination; Development; Disease; Disorder; EC 2.7; Ensure; Extracellular Signal-Regulated Kinase Gene; Extremities; Figs; Figs - dietary; Gehrig's Disease; Genetic; Genetic Alteration; Genetic Change; Genetic defect; HMG-20; High Mobility Protein 20; Hydrolase; Hydrolysis; Intracellular Communication and Signaling; Ion Channels, Sodium; Kinases; Lead; Limb structure; Limbs; Lou Gehrig Disease; MAP Kinase Gene; MAPK; Macropain; Macroxyproteinase; Maintenance; Maintenances; Mammals, Mice; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Motor; Motor Cell; Motor End-Plate; Motor Endplate; Motor Neuron Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Multicatalytic Proteinase; Murine; Mus; Muscle Rigidity; Mutation; Myoneural Junction; NRVS-SYS; Nerve; Nerve Cells; Nerve Endings, Presynaptic; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System; Nervous System Diseases; Nervous system structure; Neural Cell; Neural Transmission; Neurocyte; Neurologic; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological; Neurological Disorders; Neuromuscular Diseases; Neuromuscular Junction; Neuronal Transmission; Neurons; Non-Trunk; Pathogenesis; Pathology; Pathway interactions; Pb element; Phenotype; Phosphotransferases; Presynaptic Terminals; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteosome; Publishing; Recycling; Regulation; Reporting; Research; Rest Tremor; Rigidity; Rigidity, Muscular; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sodium Channel; Spinal Muscular Atrophy; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Transgenes; Transgenic Mice; Transgenic Organisms; Transphosphorylases; Ubiquitin; V (voltage); Work; Yeasts; biological signal transduction; design; designing; disease/disorder; effective therapy; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; insight; insoluble aggregate; intervention development; intervention therapy; motoneuron; motor neuron development; motor neuron function; mouse model; multicatalytic endopeptidase complex; muscle form; mutant; myoneural disorder; nervous system development; nervous system disorder; neurofilament; neurological disease; neuromuscular disorder; neuron cell death; neuron development; neuron loss; neuronal; neuronal cell death; neuronal loss; neurotransmission; pathway; postnatal; prevent; preventing; protein aggregate; protein degradation; public health relevance; research study; response; restoration; small molecule; social role; synapse failure; synapse function; synaptic failure; synaptic function; therapy development; trafficking; transgenic; treatment development; voltage",The role of Usp 14 in regulating neuronal function," Narrative The ubiquitin proteasome system functions to control cellular pathways by regulating protein levels within cells. Since alterations in protein turnover are believed to be central to several chronic neurological diseases, the identification and analysis of components of the ubiquitin proteasome system will provide new insights into the mechanisms of neurological disease and identify potential targets for therapeutic intervention.",47533,CDIN,Cell Death in Neurodegeneration Study Section,A2,6,320469,
7786487,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS048252-05A1,,NINDS:261795;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,PHYSIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"CHANDY, GEORGE KANIANTHARA;",1968198;,2R01NS048252,04/01/2004,12/31/2012,"ATGN; Acute; Affect; Animal Model; Animal Models and Related Studies; Antigens; Atrophic Arthritis; Autoantigens; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Autologous Antigens; Bone Resorption; Breeding; Calcium Ion Signaling; Calcium Signaling; Caliber; California; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Therapy; Cells; Cellular Migration; Cellular Proliferation; Cessation of life; Cheilitis; Chronic; Chronic GVHD; Chronic Graft Versus Host Disease; Chronic Periodontitis; Clinical; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Contact Dermatitis; Copaxone; Crab-Eating Macaque; Cutaneous; Cytofluorometry, Flow; Death; Delayed Hypersensitivity; Delayed-Type Hypersensitivity; Demyelinations; Dermatitis Venenata; Dermatoplasties; Dermatoplasty; Devices; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diameter; Disease; Disease remission; Disorder; Dose; Drugs; EAE; Eczema, Contact; Effectiveness; Effector Cell; Encephalomyelitis, Allergic; Evaluation; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence Microscopy; Frequencies (time pattern); Frequency; Future; Genetic; Goals; Greece; Histopathology; Human; Human, General; IDD; IDDM; Immune; Immune Function, Cellular; Immune response; Inflammatory Arthritis; Inflammatory Infiltrate; Injectable; Injection of therapeutic agent; Injections; Injections, Subcutaneous; Insulin-Dependent Diabetes Mellitus; Ion Channels, Potassium; K channel; KCNA3 potassium channel; Kv1.3 gene product; Kv1.3 potassium channel; Lead; Lupus; Lymphocyte Function; MS (Multiple Sclerosis); Macaca fascicularis; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Memory; Microfluorometry, Flow; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Monkey, Crab-Eating; Monkey, Cynomolgus; Monkeys; Motility; Motility, Cellular; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Needles; Osteoclastic Bone Loss; Paraffin Embedding; Pathogenesis; Patients; Pattern; Pb element; Peptides; Periodontitis; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Potassium Channel; Production; Proliferating; Pustular psoriasis; RMSN; Rat; Rattus; Regulatory T-Lymphocyte; Relapse; Relapsing-Remitting Multiple Sclerosis; Remission; Reporting; Research; Resistance; Rheumatoid Arthritis; Role; SCID-hu Mice; Safety; Sclerosis, Disseminated; Self-Antigens; Sensitivity, Contact; Severities; Skin Transplantation; Skin graft; Staging; Subcutaneous Injections; Suspension substance; Suspensions; T memory cell; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; T1 diabetes; T1D; T1DM; TEM cells; Testing; Therapeutic; Therapeutic Effect; Therapy, Cell; Thymus-Dependent Lymphocytes; Treatment Period; Tuberculin-Type Hypersensitivity; Type 1 diabetes; Type IV Hypersensitivity; V (voltage); Viral; allogenic skin graft; autoimmune disorder; autoimmune encephalomyelitis; autoreactive T cell; biomarker; cell mediated hypersensitivity; cell motility; cell-based therapy; clinical investigation; cohort; cytokine; delayed-type hypersensitivity response; design; designing; disease/disorder; drug/agent; experiment; experimental research; experimental study; flow cytophotometry; grafting, skin; heavy metal Pb; heavy metal lead; host response; immune function; immunogen; immunoresponse; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; insular sclerosis; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; memory T lymphocyte; migration; model organism; neglect; non-human primate; nonhuman primate; novel therapeutic intervention; patch clamp; pathogen; peripheral blood; prevent; preventing; pseudopsoriasis, pustular; public health relevance; research study; resistant; response; self recognition (immune); social role; suspension; terminally differentiated effector memory (TEM) T cells; terminally differentiated effector memory T cells; therapeutic target; thymus derived lymphocyte; treatment days; treatment duration; type I diabetes; voltage",K-Channels in Lymphocyte Function and Autoimmunity, Project Narrative: Our goal is to develop a therapy that suppresses or eliminates disease-causing immune cells in autoimmune diseases without compromising the protective immune response. Our strategy is to selectively target voltage-gated Kv1.3 potassium channels in effector memory T cells that are important mediators of autoimmune diseases.,48252,CMBG,Cellular and Molecular Biology of Glia Study Section,A1,5,261795,
7886465,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS048392-06A1,,NINDS:342889;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"SHEN, KANG ;",6441664;,2R01NS048392,04/01/2004,01/31/2015,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Axon; Axon Terminals; Axonal Transport; Axoplasmic Transport; Brain; C elegans; C.elegans; CDC2 Protein Kinase; CDK; CDK1; Caenorhabditis elegans; Cell Body; Cell Cycle Controller cdc2; Cell Division Control Protein 2 Homolog; Cell Division Cycle 2; Cell Division Cycle 2 Protein; Chemical Synapse; Communication; Cues; Cyclin-Dependent Kinase 1; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dendrites; Development; Disease; Disorder; Distal; Encephalon; Encephalons; Event; Feedback; GTP Phosphohydrolases; GTPases; Genetic; Genetic Screening; Grant; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Kinesin; Light; Location; Mediating; Micro-tubule; Microtubules; Modeling; Modification; Molecular; Molecular Motors; Motor; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Pathogenesis; Pathway interactions; Pattern; Photoradiation; Physiologic; Physiological; Presynaptic Terminals; Primary Senile Degenerative Dementia; Property; Property, LOINC Axis 2; Proteins; Proteomics; Publishing; Recruitment Activity; Regulation; Research; Specific qualifier value; Specificity; Specified; Stereotyping; Structure; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Vesicles; System; System, LOINC Axis 4; Testing; Transport Vesicles; VESCL; Vesicle; base; cdc2 gene product; cdc2+ Protein; cdk Proteins; cdk1 Kinase; cell body (neuron); dementia of the Alzheimer type; disease/disorder; extracellular; gene function; gene product; guanosinetriphosphatase; in vivo; insight; mutant; neural; neural cell body; neurodegenerative illness; neuronal; neuronal cell body; p34 (cdc2); p34 Protein Kinase; p34CDC2; pathway; presynaptic; primary degenerative dementia; public health relevance; recruit; relating to nervous system; senile dementia of the Alzheimer type; soma; synapse formation; synaptogenesis; trafficking",Mechanisms of Synaptic Specificity in C. elegans," Synapses are critical for the communication between neurons. During synapse formation, proteins and vesicle are transported to presynnaptic terminals in distal axons. The proposed study characterizes critical regulatory mechanisms for trafficking synaptic components to axons as well as locally synaptic assembly. This project will potentially shed light on the pathogenesis mechanisms of neurodegenerative diseases such as the Alzheimer's disease.",48392,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",A1,6,342889,
7888734,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS048476-06,,NINDS:362031;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROSURGERY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"VAN DEN POL, ANTHONY N;",1866641;,2R01NS048476,07/01/2004,01/31/2015,"21+ years old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Adult; Adverse effects; Agonist; Aminalon; Aminalone; Amino Acids; Animals; Anti-Anxiety Agents; Anti-Anxiety Drugs; Antidiuretic Hormone; Antidiuretic Hormones; Antihormone Agents; Anxiety; Anxiolytic Agents; Anxiolytics; Apoplexy; Arcuate Nucleus; Area; Aujeszky's Disease Virus; Aujeszkys Disease Virus; Autoregulation; Axon; Bicarbonates; Blood; Body Weight; Body fat; Brain; Brain region; Butanoic acid, 4-amino-; Cardiac Diseases; Cardiac Disorders; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Code; Coding System; Connector Neuron; Data; Disinhibition; Dorsomedial Hypothalamic Nucleus; Eating; Electron Microscopy; Encephalon; Encephalons; Epidemic; Exercise; Exercise, Physical; Food Intake; Frequencies (time pattern); Frequency; GABA; Genes; Genes, Reporter; Grant; HCO3; Health; Health Care Costs; Health Costs; Healthcare Costs; Heart Diseases; Herpesvirus 1 (alpha), Suid; Herpesvirus 1, Suid; Herpesvirus Suis; Homeostasis; Hormone Antagonists; Human; Human, Adult; Human, General; Hydrogen Carbonates; Hydrogen Oxide; Hypothalamic structure; Hypothalamus; Infundibular Nucleus; Intercalary Neuron; Intercalated Neurons; Intermediary Metabolism; Interneurons; Internuncial Cell; Internuncial Neuron; Kidney; Knowledge; Label; Lateral; Lead; Locus Coeruleus; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Medial; Mediating; Membrane; Membrane Potentials; Metabolic Processes; Metabolism; Mice; Mice, Transgenic; Modeling; Morphology; Mortality; Mortality Vital Statistics; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurohypophysis; Neuromodulator; Neurons; Neuropeptides; Nucleus; Nucleus Pigmentosus Pontis; Obesity; Paper; Pb element; Peptides; Physiologic; Physiological; Physiological Homeostasis; Physiology; Pituitary Gland, Posterior; Play; Population; Posterior Lobe of the Pituitary Gland; Posterior Pituitary Gland; Probability; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Pseudorabies virus; QOL; Quality of life; Receptor Protein; Regulation; Reporter; Reporter Genes; Reporting; Resistance; Resting Potentials; Reticuloendothelial System, Blood; Risk; Role; Site; Sleep; Sleep Wake Cycle; Slice; Social Interaction; Societies; Stroke; Structure; Structure of dorsomedial hypothalamic nucleus; Structure of locus ceruleus; Structure of nucleus infundibularis hypothalami; Subcellular Process; Suid Herpesvirus 1; Swine Herpesvirus 1; System; System, LOINC Axis 4; Testing; Tranquilizing Agents, Minor; Transgenic Mice; Transmembrane Potentials; Treatment Side Effects; Urinary System, Kidney; VSV; Vascular Accident, Brain; Vasopressins; Vesicular Stomatitis Virus; Vesicular stomatitis Indiana virus; Viral Vector; Water; Weight Gain; Weight Increase; Whole-Cell Recordings; Work; adiposity; adult human (21+); aminoacid; antianxiety agent; base; behavioral disinhibition; beta-Hypophamine; blue nucleus; body weight gain; body weight increase; brain attack; cell type; cerebral vascular accident; corpulence; corpulency; corpulentia; density; experiment; experimental research; experimental study; fascinate; feeding; gamma-Aminobutyric Acid; gene product; heart disorder; heavy metal Pb; heavy metal lead; hormone inhibitor; human disease; hypothalamic; immunocytochemistry; innervation; interest; locus ceruleus structure; magnocellular; melanin-concentrating hormone; melanin-concentrating hormone receptor; melanophore-concentrating hormone; melanosome concentrating hormone; membrane structure; mental state; nerve supply; neuronal; obese; obese people; obese person; obese population; patch clamp; posterior lobe of pituitary; posterior pituitary; postsynaptic; presynaptic; public health relevance; receptor; receptor, MCH; receptor, melanine-concentrating hormone; renal; research study; resistant; response; selective expression; selectively expressed; side effect; social role; stroke; therapy adverse effect; treatment adverse effect; voltage clamp; wt gain",Response properties of hypothalamic MCH neurons," PI: van den Pol, A.N. PROJECT NARRATIVE  Some neurons have a very narrow function. For instance, the magnocellular vasopressin neurons send axons only to the neurohypophysis, and release neuropeptide into the blood to increase water retention in the kidney. In contrast, hypothalamic melanin concentrating hormone (MCH) neurons send axons to over a hundred different brain regions, and appear to exercise a strong modulation of a number of different functions, the foremost of which is modulation of energy homeostasis, body weight, and body fat content. Blocking MCH receptors causes a reduction in food intake, and a decrease in body weight, particularly body fat, and an increase in metabolism. Animals lacking the MCH receptor are resistant to dietary obesity, a growing problem in the USA. In addition, MCH neurons play a role in mental states; modulating MCH actions can reduce anxiety and increase social interaction, and may modulate sleep-wake cycles. We do not yet have a substantive understanding either of how the MCH neuropeptide acts in the brain, nor how the MCH neuron receives and integrates information from other neurons and from the periphery. In today's society, we have both a growing epidemic of obesity that leads to a large number of side effects that reduce quality of life, and increase the cost of health care. Our plan is to unravel some of the complexity surrounding the cellular actions of the MCH peptide, and to test several related hypotheses focusing on how MCH neurons integrate incoming and outgoing information. By better understanding how MCH neurons function at the cellular level, we will be better able to understand how the cell plays such key roles in such a wide variety of functions, and with this knowledge, we will be better able to work through the MCH neuronal system to treat or ameliorate related human health problems.",48476,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,6,362031,
7882116,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS048952-06,,NINDS:597877;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW ORLEANS,UNITED STATES,NONE,02,053785812,US,LA,70118,TULANE UNIVERSITY OF LOUISIANA,"PHILIPP, MARIO TOMAS;",1884575;,2R01NS048952,07/01/2004,01/31/2015,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; ANXA5; Aacidexam; Address; Adexone; Affect; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anchorin CII; Anemul mono; Animals; Annexin A5 Protein; Annexin V; Anterior Horn Cells; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antiinflammatories; Antiinflammatory Agents; Antimicotico; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Aquapred; Arthropoda; Arthropods; Assay; Astrocytes; Astrocytus; Astroglia; Auxiloson; Azona; B. burgdorferi; B.burgdorferi; Baycuten; Baycuten N; Bioassay; Biologic Assays; Biological Assay; Blood monocyte; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; Brain; C-C Chemokines; CASP-3; CASP3; CBP-I; CCL2; CCL2 gene; CD49c Antigens; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; CSBP1; CSBP2; CSPB1; Calphobindin I; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Central Nervous System; Cerebrospinal Fluid; Chemokines, CC; Co-culture; Cocultivation; Coculture; Coculture Techniques; Common Rat Strains; Complex; Confocal Microscopy; Control Groups; Corson; Cortidexason; Cortisumman; Cysteine Protease CPP32; Cytofluorometry, Flow; Data; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Dorsal Root Ganglia; Drugs; ELISA; EXIP; Encephalon; Encephalons; Endonexin II; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated Kinase Gene; FRP-2; Face; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Fusion Regulatory Protein-2; GDCF-2; GDCF-2 HC11; Gammacorten; Ganglia, Spinal; Genes; Glia; Glial Cells; Glucocorticoids; Goals; Grant; HC11; Hexadecadrol; Hexadrol; Hortega cell; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Nick-End Labeling; In Vitro; Incubated; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Integrin alpha3; JNK; JNK1; JNK1A2; JNK21B1/2; Killings; Kolliker's reticulum; Lead; Life; Ligands; Lipocortin-V; Lokalison-F; Loverine; Lyme Borreliosis; Lyme Disease; Lyme Disease Spirochete; Lyme Neuroborreliosis; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; MCAF; MCP-1; MCP1; MGC9434; Macaca mulatta; Macrophage Activation; Mammals, Rats; Marrow monocyte; Measurement; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Memory Loss; Meningitis; Methylfluorprednisolone; Microfluorometry, Flow; Microglia; Microscopy; Microscopy, Confocal; Millicorten; Mitogen-Activated Protein Kinase Gene; Modeling; Monitor; Mxi2; Myelogenous; Myeloid; Mymethasone; Nerve Cells; Nerve Conduction; Nerve Pain; Nerve Unit; Nervous System Lyme Borreliosis; Nervous System Lyme Disease; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neural Conduction; Neuraxis; Neuroborreliosis, Borrelia burgdorferi; Neurocognitive; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neurons, Anterior Horn; Non-neuronal cell; Ocasa; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Order Spirochaetales; Orgadrone; PAP-I; PARP Cleavage Protease; PC-12; PC12 Cells; PP4; PRKM14; PRKM15; PRKM8; Palsy; Paralysed; Pathogenesis; Pathway interactions; Pb element; Peripheral; Peripheral Nerves; Phagocytes; Phagocytic Cell; Pharmaceutic Preparations; Pharmaceutical Preparations; Pheochromocytoma Cell Line; Placental Anticoagulant Protein I; Placental Protein 4; Plegia; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Process; Progress Reports; RNA, Small Interfering; Rat; Rattus; Receptor Protein; Reporting; Reports, Progress; Research; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; SAPK1; SAPK2A; SCA-1; SCYA2; SMC-CF; SREBP Cleavage Activity 1; Sensory; Small Interfering RNA; Source; Spersadex; Spersadox; Spinal Ganglia; Spirochaetales; Spirochetes; Steroid Compound; Steroids; TIL4; TLR1; TLR1 protein; TLR1 receptor; TLR2; TLR2 gene; TUNEL; TUNEL Assay; TdT-Mediated dUTP Nick End Labeling Assay; Therapeutic Glucocorticoid; Thromboplastin Inhibitor; Time; Toll-Like Receptor 1; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin-1 Receptor-Like; Transcript; United States; VAC-Alpha; Vascular Anticoagulant-Alpha; Ventral Horn Cells; Ventral Horn Neurons; Visumetazone; Yama; Yama protein; alpha(3) Integrin; amebocyte; annexin A5; apoptosis of neuronal cells; auricularum; base; beta-Chemokines; brain tissue; caspase-3; cultured cell line; cysteine protease P32; disease/disorder; dorsal root ganglion; drug/agent; experiment; experimental research; experimental study; facial; flow cytophotometry; gitter cell; heavy metal Pb; heavy metal lead; in vivo; lyme spirochete; meloxicam; member; mesoglia; microglial cell; microgliocyte; miloxicam; monocyte; nerve cement; neuron apoptosis; neuronal; neuronal apoptosis; p38; p38 MAPK Gene; p38Alpha; paralysis; paralytic; pathway; perivascular glial cell; pheochromocytoma 12 cell line; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; public health relevance; receptor; research study; response; siRNA; social role; spinal fluid; terminal nick end labeling; tissue culture",Lyme neuroborreliosis pathogenesis in the rhesus monkey," Project Narrative Lyme disease, the most frequently reported arthropod-borne disease in the United States is caused by the spirochete Borrelia burgdorferi. Lyme neuroborreliosis is a form of Lyme disease that affects both the peripheral and central nervous systems, causing facial paralysis, nerve pain, sensory loss, weakness, meningitis, neurocognitive abnormalities, and loss of memory. Based on evidence collected in the preceding grant period we will address the hypothesis that inflammation brought about by the interaction between microglia, the brain phagocytic cell, and B. burgdorferi, causes Lyme neuroborreliosis by killing neurons and oligodendrocytes. This research could lead to a new way of treating Lyme neuroborreliosis.",48952,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,6,597877,
7887698,R01,NS,2,,01/19/2010,12/31/2010,PA-07-070,2R01NS049203-06A1,,NINDS:315110;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,IRVINE,UNITED STATES,ORTHOPEDICS,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"GUPTA, RANJAN ;",6476995;,2R01NS049203,01/19/2010,12/31/2014,"American; Atrophy, Muscle; Basal lamina; Bioreactors; Blotting, Western; Carpal Tunnel Syndrome; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cell-Extracellular Matrix; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Chondroitin Sulfate Proteoglycan; Chronic; Clinical; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen; Complex; Compression Neuropathy, Carpal Tunnel; Constriction, Pathologic; Constriction, Pathological; Cranin; Cubital Tunnel Syndrome; Custom; Demyelinations; Disease; Disorder; Doppler Echocardiography; Doppler Study; Dorsal Root Ganglia; Dysfunction; Dystroglycan; Dystroglycans; EC 2.7; ECM; Echocardiography, Doppler; Electromagnetic, Laser; Entrapment Neuropathy, Carpal Tunnel; Environment; Erinaceidae; Esthesia; Event; Experimental Models; Experimental Models, Other; Extracellular Matrix; Extracellular Matrix, Integrins; Fibroblasts; Fibrosis; Functional disorder; Ganglia, Spinal; Glucose Binding Protein; Glucose Transporter; Glycoprotein GP-2; Goals; Hedgehogs; Hypoxia; Hypoxic; INFLM; In Vitro; Inflammation; Inflammatory; Injury; Integrins; Intracellular Communication and Signaling; Ischemia; Kinases; Knowledge; Laminin; Lasers; Mammals, Mice; Measures; Mechanical Stress; Mechanics; Median Neuropathy, Carpal Tunnel; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Modeling; Models, Experimental; Molecular; Morbidity; Morbidity - disease rate; Murine; Mus; Muscular Atrophy; Myelin; Nerve compression syndrome; Nervous; Neurilemma Cell; Neurilemmal Cell; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Oxygen Deficiency; Oxygen measurement, partial pressure, arterial; PNS Diseases; Pain; Painful; Pathogenesis; Pathway interactions; Pattern; Peripheral Nerve Diseases; Peripheral Nerves; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Phase; Phosphotransferases; Physicians; Physiopathology; Predisposition; Process; Proteins; RT-PCR; RTPCR; Radiation, Laser; Research; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells; Scientist; Secondary to; Sensation; Signal Transduction; Signal Transduction Systems; Signaling; Source; Spinal Ganglia; Spinal Nerve Roots; Spinal Roots; Spinal nerve root structure; Stenosis; Stress, Mechanical; Subcellular Process; Surgeon; Susceptibility; Symptoms; System; System, LOINC Axis 4; Testing; Time; To specify; Transgenic Organisms; Translating; Translatings; Transphosphorylases; Transport Protein, Glucose; Ulnar Nerve Compression, Cubital Tunnel; Ulnar Nerve Entrapment, Elbow; VEGFs; Vascular Endothelial Growth Factors; Vegf; Wallerian Degeneration; Western Blotting; Western Blottings; Western Immunoblotting; Work; arterial pO2; axonal degeneration; biological signal transduction; clinical care; design; designing; disease/disorder; dorsal root ganglion; extracellular; gene product; improved; in vitro Model; in vivo; language translation; myelination; nerve injury; neural; neural injury; novel; null mutation; oxygen tension; pathophysiology; pathway; protein blotting; public health relevance; relating to nervous system; response; reverse transcriptase PCR; secondary degeneration; transcription factor; transgenic",Schwann Cell Control of Chronic Nerve Injury," PROJECT NARRATIVE Millions of Americans suffer from chronic nerve compression (CNC) injuries such as carpal tunnel syndrome, cubital tunnel syndrome and spinal nerve root stenosis. Over the past eight years our research described for the first time that CNC injuries are a distinct entity characterized by the loss of myelin without axonal injury, the proliferation of Schwann cells and a lack of inflammation. The goal of this application is to build upon our previous research in the hopes of identifying the key molecular pathways involved in the disease process so that we will have the potential to design novel new therapies by targeting these specific pathways.",49203,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,A1,6,315110,
7794796,R01,NS,2,,01/15/2010,11/30/2010,PA-07-070,2R01NS049501-06A1,,NINDS:336875;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"YANG, XIANGDONG WILLIAM;",8334468;,2R01NS049501,09/01/2004,11/30/2014,"Address; Affect; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Behavioral; Brain; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells; Cessation of life; Chronic; Clinical; Cognitive; Corpus Striatum; Corpus striatum structure; DISSEC; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disease; Disorder; Dissection; Encephalon; Encephalons; Gene Expression Inhibitor; Genetic; Genetic Models; Grant; Gray; Gray unit of radiation dose; HD protein, human; Hereditary; Huntingtin; Huntingtin Protein; Huntingtin protein, human; Huntington Chorea; Huntington Disease; Huntington disease protein, human; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntington's disease gene product; Huntingtons Disease; IT15 protein, human; Inherited; Knowledge; Laboratories; Length; Mammalian Genetics; Mammals, Mice; Mice; Mice, Transgenic; Modeling; Models, Genetic; Molecular; Motor; Murine; Mus; N-terminal; NH2-terminal; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Oligonucleotides, Antisense; Onset of illness; Pathogenesis; Patients; Pattern; Phenotype; Poly Q; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Pyramidal neuron; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Risk; Sequence-Specific Posttranscriptional Gene Silencing; Series; Striate Body; Striatum; Symptoms; Testing; Therapeutic; Toxic effect; Toxicities; Transgenes; Transgenic Mice; Triad; Triad Acrylic Resin; Triad resin; cell type; cellular targeting; design; designing; disease onset; disease phenotype; disease/disorder; disorder onset; drug discovery; gene product; hippocampal pyramidal neuron; human Huntingtin protein; in vivo; mouse model; mutant; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; novel; poly(glutamine); polyQ; polyglutamine; public health relevance; selective expression; selectively expressed; striatal",Conditional Models: non-cell-autonomous Toxicities in HD," Project Narrative Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders affecting 30,000 patients in the US and another 150,000 at risk. Currently, HD is not treatable or curable, and the patients invariably suffer from the motor, cognitive and psychiatric symptoms that often relentlessly progress toward an eventual bedridden state and death about 10-20 years after the disease onset. Our proposed study is aimed at identifying the critical neuronal cell types targeted by toxic mhtt to elicit the key disease phenotypes in HD. Hence, our study may provide the crucial cellular targets from which we can dissect the molecular pathogenic mechanisms and to deliver HD therapeutics.",49501,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,A1,6,336875,
7781063,R01,NS,2,,05/01/2010,04/30/2011,PA-07-070,2R01NS050730-06A1,,NINDS:332500;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AUGUSTA,UNITED STATES,NEUROLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"BRANN, DARRELL W (contact);VADLAMUDI, RATNA K;",1872706 (contact);6884204;,2R01NS050730,12/01/2004,04/30/2015,"Acetylation; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Androstenedione Aromatase; Androstenedione Aromatase Inhibitor; Animal Model; Animal Models and Related Studies; Anti-Sense Oligonucleotides; Antioxidants; Antisense Agent; Antisense Oligonucleotides; Apoplexy; Aquadiol; Area; Aromatase; Aromatase Cytochrome P450; Aromatase Inhibitors; Attenuated; Binding; Binding (Molecular Function); Biological; Brain; Breast Cancer Cell; CHIP assay; CYP 19; CYP19 Protein; CYPXIX; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; ChIP (chromatin immunoprecipitation); Change of Life, Female; Chromatin; Cloning; Complex; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); Cytoplasm; DNA Methylation; Data; Deacetylase; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dimenformon; Diogyn; Diogynets; Dose; EC 2.1.1; EC 2.7; ER Status; Effectiveness; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptor Status; Estrogen Receptors; Estrogen Synthase; Estrogen Synthase Inhibitor; Estrogen Synthetase; Estrogen Synthetase Inhibitor; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exons; Female Health; Fore-Brain; Forebrain; Gene Expression Inhibitor; Gene Inactivation; Gene Silencing; Genomics; Glutamic Acid; Human Breast Cancer Cell; Idiopathic Parkinson Disease; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Knockout Mice; L-Glutamic Acid; L-Leucine; L-Proline; Laboratories; Leucine; Leucine, L-Isomer; Lewy Body Parkinson Disease; Light; Link; Mammals, Mice; Mediating; Menopause; Methylation; Methyltransferase; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Modification; Molecular Interaction; Murine; Mus; Nervous; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nuclear Receptors; Nucleus; Null Mouse; Oligonucleotides, Antisense; Organ System, Cardiovascular; Organism-Level Process; Organismal Process; Ovocyclin; Ovocylin; P450AROM; PXXP Motif; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Phosphorylation; Phosphotransferases; Photoradiation; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Parkinsonism; Primary Senile Degenerative Dementia; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Progynon; Proline; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Prosencephalon; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Regulation; Research; Role; SH3 Domains; SRC Homology Region 3 Domain; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Stroke; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Translations; Transphosphorylases; Vascular Accident, Brain; Vascular, Heart; Wild Type Mouse; Women's Health; Work; anti-oxidant; attenuation; base; biological signal transduction; brain attack; cerebral vascular accident; chromatin immunoprecipitation; circulatory system; dementia of the Alzheimer type; deprivation; gene product; genetic promoter element; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; menopausal; methylase; model organism; mouse model; neural; neurodegenerative illness; neuroprotection; non-genomic; nongenomic; novel; primary degenerative dementia; programs; public health relevance; receptor expression; relating to nervous system; senile dementia of the Alzheimer type; social role; stroke; transmethylase",Mechanisms of Estrogen Signaling and Neuroprotection," Principal Investigator/Program Director (Last, First, Middle): Brann, Darrell W. Estrogen (E2) has been implicated to exert neuroprotection in a variety of neurodegenerative disorders, including stroke. This proposal would elucidate the mechanisms underlying E2 neuroprotection in the brain and potentially provide a mechanistic explanation as to why the Women's' Health Initiative (WHI) studies failed to observe beneficial effect of E2. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page",50730,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,A1,6,332500,
7783561,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS050968-06,,NINDS:397432;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,NEUROLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"SNIDER, WILLIAM D;",1908912;,2R01NS050968,09/15/2004,01/31/2015,"0-11 years old; 21+ years old; Adult; Alleles; Allelomorphs; Ammon Horn; Autoregulation; Brain; Breeding; CCI-779; Cell Communication and Signaling; Cell Count; Cell Cycle; Cell Cycle Inhibitor 779; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Number; Cell Proliferation; Cell Signaling; Cellular Proliferation; Chemicals; Child; Child Youth; Children (0-21); Cornu Ammonis; DNA Recombination; DNA recombination (naturally occurring); Dentate Fascia; Dentate Gyrus; Development; Dorsal; Drugs; EC 2.7; Embryo; Embryonic; Embryonic Nervous System; Encephalon; Encephalons; Erinaceidae; Exhibits; Family member; Fascia Dentata; Funding; GSK-3; Genetic; Genetic Recombination; Genetics-Mutagenesis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Gyrus Dentatus; Hedgehogs; Hippocampus; Hippocampus (Brain); Homeostasis; Human, Adult; Human, Child; Intracellular Communication and Signaling; Investigation; Kinases; Knock-in; Knock-in Mouse; Li+ element; Life; Lithium; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mice; Molecular Biology, Mutagenesis; Mother Cells; Murine; Mus; Mutagenesis; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neuronal Differentiation; Neuronal Growth; Neurons; Notch Signaling Pathway; PTK Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Physiological Homeostasis; Point Mutation; Population; Position; Positioning Attribute; Progenitor Cells; Proteins; Proteolysis and Signaling Pathway of Notch; RTK; Radial; Rapamune; Rapamycin; Rapamycin Analog; Rapamycin Analog CCI-779; Receptor Protein-Tyrosine Kinases; Recombination; Recombination, Genetic; Regulation; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Stem cells; Structure of dentate gyrus; Telencephalon; Testing; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Transplantation; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Work; adult human (21+); biological signal transduction; cell imaging; cell type; cellular imaging; chemical genetics; children; clinical practice; dentate gyrus; drug/agent; experiment; experimental research; experimental study; extracellular; gene product; granule cell; gsk-3 Gene Product; hippocampal; in vivo; inhibitor; inhibitor/antagonist; nerve stem cell; nestin; nestin protein; neural; neural progenitor cells; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; notch; notch protein; notch receptors; postnatal; progenitor; public health relevance; relating to nervous system; research study; self-renewal; transplant; youngster",GSK-3 is a Master Regulator of Neural Progenitor Self-Renewal," Narrative Statement We propose that a specific protein, GSK-3, is a master regulator of neural stem cells. This function of GSK-3 requires investigation because a GSK-3 inhibitor, lithium, is commonly used in clinical practice, increasingly in children. Our results may also suggest new ways to expand neural stem cells in the setting of neural transplantation",50968,ZRG1,Special Emphasis Panel,,6,397432,
7741129,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS051630-05,,NINDS:753613;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,GENETICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"JIN, PENG  (contact);NELSON, DAVID LOREN;",7081055 (contact);7358259;,2R01NS051630,04/01/2005,01/31/2014,"5' Untranslated Regions; 5'UTR; APF-1; ATP-Dependent Proteolysis Factor 1; Affect; Age of Onset; Alleles; Allelomorphs; Behavioral; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Brain; CGG repeat; Cell Culture Techniques; Cell model; Cellular model; Cerebellum; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disturbance in cognition; Dropout; Drosophila; Drosophila genus; Drug Therapy; Encephalon; Encephalons; Enhancers; Escalante syndrome; FMR1 Gene; FXTAS; Family; Flies; Fmr1 gene,; Fragile X; Fragile X Mental Retardation 1 Gene; Fragile X Premutation; Fragile X Syndrome; Fragile X premutation-associated tremor ataxia syndrome; Fruit Fly, Drosophila; Funding; Future; Gait Ataxia; Gene Products, RNA; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; HMG-20; High Mobility Protein 20; Immune Precipitation; Immunoprecipitation; Impaired cognition; Individual; Intention Tremor; Intermediary Metabolism; Intranuclear Inclusion Bodies; Intranuclear Inclusions; Knock-in; Knock-in Mouse; Ligand Binding Protein; METBL; Mammalia; Mammals; Mammals, General; Mammals, Mice; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Mediating; Metabolic Processes; Metabolism; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mutation; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological Development Disorder; Neuron Degeneration; Neurons; Nuclear Inclusion; Nuclear Inclusion Bodies; Ortholog; Orthologous Gene; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Pathogenesis; Pathway interactions; Patients; Pharmacotherapy; Phenotype; Play; Proteins; Purkinje Cells; Purkinje's Corpuscles; RNA; RNA, Non-Polyadenylated; RNA-Binding Proteins; Renpenning syndrome 2; Research; Ribonucleic Acid; Role; Targetings, Gene; Testing; Toxic effect; Toxicities; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Tremors, Action; Trinucleotide Repeats; Triplet Repeats; Ubiquitin; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; base; cerebellar Purkinje cell; codon reiteration; cognitive dysfunction; cognitive loss; cognitively impaired; fly; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X associated tremor ataxia syndrome; fragile X mental retardation 1; fragile X-associated tremor/ataxia syndrome; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; fruit fly; gain of function; gene product; genome mutation; hnRNP A2; hnRNP A2-B1; language translation; loss of function mutation; mRNA Leader Sequences; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; male; mar(X) syndrome; marker X syndrome; mental retardation-macroorchidism syndrome; mouse model; neural degeneration; neurodegeneration; neurodegenerative illness; neuron toxicity; neuronal; neuronal degeneration; neuronal toxicity; neurotoxicity; novel; overexpression; pathway; public health relevance; social role; stem; transgenic",Molecular Basis of rCGG-Mediated Neurodegeneration," Project Narrative: Fragile X-associated tremor/ataxia syndrome (FXTAS), a late age of onset neurodegenerative disorder, is mainly associated with older males of fragile X premutation carriers. The long-term goal of this project is to understand the molecular pathogenesis of FXTAS. Here we will use both Drosophila and mouse models to further test the hypothesis that FXTAS results from abnormal RNA metabolism that stems from inappropriate association of RBPs with the RNA produced by FMR1 premutation alleles.",51630,CDIN,Cell Death in Neurodegeneration Study Section,,5,753613,
7896012,R01,NS,2,,01/15/2010,12/31/2010,PA-07-070,2R01NS051852-06,,NINDS:376250;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,,00,143983562,US,DC,20010,CHILDREN'S RESEARCH INSTITUTE,"HAYDAR, TARIK F;",1952627;,2R01NS051852,01/15/2010,12/31/2014,"Ablation; Astrocytes; Astrocytus; Astroglia; Brain; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Central Nervous System; Data; Development; ECM; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Extracellular Matrix; Extracellular Matrix, Integrins; Fore-Brain; Forebrain; Funding; Generalized Growth; Genetic; Glia; Glial Cells; Goals; Growth; Heterogeneity; Human; Human, General; Individual; Integrins; Intracellular Communication and Signaling; Kinetic; Kinetics; Kolliker's reticulum; Maintenance; Maintenances; Mammals, Mice; Mammals, Primates; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maps; Measures; Methods and Techniques; Methods, Other; Mice; Mitotic; Molecular; Monkeys; Morphology; Mother Cells; Multipotent Stem Cells; Murine; Mus; Names; Neocortex; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neural Growth; Neural Stem Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neuronal Growth; Neurons; Non-neuronal cell; Output; Primates; Progenitor Cells; Prosencephalon; Publishing; Radial; Rodent; Rodentia; Rodentias; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Surface; Techniques; Telencephalon; Testing; Time; Tissue Growth; Ventricular; biological signal transduction; cell type; daughter cell; design; designing; developmental neurobiology; experiment; experimental research; experimental study; homotypical cortex; in vivo; innovate; innovation; innovative; isocortex; migration; multipotent progenitor; neocortical; neopallium; nerve cement; nerve stem cell; neural; neural precursor cell; neural progenitor cells; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; novel; ontogeny; postnatal; precursor cell; prenatal; progenitor; public health relevance; relating to nervous system; research study; social role; spatiotemporal; stem; unborn",Heterogeneity of forebrain neural precursors," Project Narrative How the rich diversity in types of forebrain neurons is achieved during development is not well understood. In this project, we build upon our novel findings that different types of neural stem and progenitor cells exist in the embryonic brain and generate neurons via distinct mechanisms. Using in vivo molecular approaches to measure proliferation, neurogenesis and allocation of progeny from individual precursor groups, this study will uncover the spatiotemporal inter-relationships between these precursor cells and determine how interaction with the extracellular matrix in the germinal zone controls their neuronal output.",51852,NCF,Neurogenesis and Cell Fate Study Section,,6,376250,
7807583,R01,NS,2,,02/01/2010,12/31/2010,PA-07-070,2R01NS054281-05,,NINDS:377729;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW ORLEANS,UNITED STATES,OTHER BASIC SCIENCES,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"CANAVIER, CARMEN CASTRO;",1891044;,2R01NS054281,09/15/2005,12/31/2014,"Accounting; Anterior; Attention; Behavior; Biological; Brachyura; Cognition; Complex; Coupled; Coupling; Crabs; Crabs, Short-Tailed; Crabs, True; Dilator; Epilepsy; Epileptic Seizures; Epileptics; Exhibits; Frequencies (time pattern); Frequency; Generations; Goals; Heterogeneity; Hybrids; Information Processing/Storage/Retrieval; Information Storage and Retrieval; Lateral; Length; Lobster; Locomotion; Locomotor Activity; Maps; Measures; Mediating; Mental disorders; Mental health disorders; Methods; Modeling; Motor; Motor Activity; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System Diseases; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurons; Noise; Pace Stimulators; Pacemakers; Pattern; Pattern Formation; Perception; Phase; Population; Production; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Respiration; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Stimulators, Electrical, Pace; System; System, LOINC Axis 4; Testing; Tremor; Unspecified Mental Disorder; Work; base; central pattern generator; cognitive function; dementia praecox; epilepsia; epileptiform; epileptogenic; improved; mental illness; nervous system disorder; neural circuit; neural circuitry; neurological disease; neuron component; neuronal; psychological disorder; public health relevance; respiratory mechanism; schizophrenic; theories; tool",CRCNS: Analysis of synchronization in hybrid neural circuits," The purpose of this work is to understand basic mechanisms of synchronization and pattern formation in the nervous system. Networks of biological neurons can spontaneously generate patterned activity that underlies rhythmic, repetitive motor behaviors such as respiration and locomotion, and transient synchronization in cortical networks is hypothesized to mediate cognitive functions such as attention, perception, and information storage and retrieval. A better understanding of these mechanisms will provide tools to determine how synchronization goes awry in neurological disorders such as epilepsy and tremor, or in psychiatric disorders in which cognition is impaired.",54281,ZRG1,Special Emphasis Panel,,5,377729,
7783516,R01,NS,2,,02/01/2010,01/31/2011,PA-07-070,2R01NS054814-05,,NINDS:334513;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,BIOCHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HARTENSTEIN, VOLKER ;",1866660;,2R01NS054814,02/01/2006,01/31/2015,"21+ years old; Address; Adult; Animals; Area striata; Area striata structure; Atlases; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Behavior Control; Behavioral Manipulation; Bio-Informatics; Bioinformatics; Biological Neural Networks; Brain; Brain Part; Caliber; Cell Body; Cognition; Communities; Complex; Computer Programs; Computer software; Cortex, Striate; Data; Data Set; Dataset; Dendrites; Development; Diameter; Disease; Disorder; Drosophila; Drosophila genus; Electron Microscopy; Electronics; Elements; Embryo; Embryonic; Encephalon; Encephalons; Exhibits; Fascicle; Fruit Fly, Drosophila; Funding; Genes; Genetic; Grant; Human, Adult; Image; Individual; Kanner's Syndrome; Learning; Light; Maps; Memory; Mental disorders; Mental health disorders; Modeling; Mushroom Bodies; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Stem Cell; Neurites; Neurobiology; Neurocyte; Neurons; Pharmacological Treatment; Photoradiation; Population; Prefrontal Cortex; Primary visual cortex; Process; Psychiatric Disease; Psychiatric Disorder; Relative; Relative (related person); Research; Schizophrenia; Schizophrenic Disorders; Software; Spinal Column; Spine; Staging; Stereotyping; Striate area; Surface; Synapses; Synaptic; Technology; Testing; Time; Unspecified Mental Disorder; Vertebral column; adult human (21+); area striata; backbone; base; behavioral control; cell body (neuron); computer program/software; data mining; datamining; dementia praecox; develop software; developing computer software; digital; digital models; disease/disorder; fruit fly; imaging; improved; insight; interest; knowledge base; mental illness; motor control; mutant; nerve stem cell; neural; neural cell body; neural circuit; neural circuitry; neural network; neural progenitor cells; neurobiological; neuroblast; neuronal; neuronal cell body; neuronal progenitor; neuronal progenitor cells; psychological disorder; public health relevance; reconstruction; relating to nervous system; schizophrenic; software development; soma; tool",3D Digital Modeling of the Developing Drosophila Brain," Narrative Drosophila serves as an important model to study how neural circuits develop and function to control behavior. The Drosophila brain is formed by an invariant set of lineages, each of which is derived from a unique neural stem cell (neuroblast) and forms a genetic and structural unit of the brain. We will use bioinformatics tools to generate a comprehensive digital atlas of the Drosophila brain lineages and their connections, which can be used by the neurobiology community at large to map and analyze neurons and circuits.",54814,NT,Neurotechnology Study Section,,5,334513,
7807616,R13,MH,2,,01/06/2010,11/30/2010,PA-08-149,2R13MH083464-02,,NIMH:38474;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,IRVINE,UNITED STATES,PSYCHIATRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"LAKATOS, ANITA ;",10425748;,2R13MH083464,05/21/2008,11/30/2012,"Brain; Brain imaging; Clinical Research; Clinical Study; Complex; Development; Diagnosis; Discipline; Disease; Disorder; Dysfunction; Encephalon; Encephalons; Environment; Evaluation; Foundations; Functional disorder; Future; Generalized Growth; Genetic; Goals; Growth; Human; Human, General; Image; Imagery; Individual Differences; International; Investigators; Knowledge; Man (Taxonomy); Man, Modern; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Nervous System, Brain; Physiopathology; Psychiatric Disease; Psychiatric Disorder; Research; Research Personnel; Researchers; Role; Scholarship; Science of Statistics; Statistics; Students; Techniques; Tissue Growth; Unspecified Mental Disorder; Visualization; base; brain visualization; conference; data mining; datamining; disease/disorder; imaging; improved; innovate; innovation; innovative; meetings; mental illness; neuroimaging; novel; ontogeny; pathophysiology; psychological disorder; social role; statistics; symposium",International Imaging Genetics Conference,"Understanding genetic influences on brain function and dysfunction through the integration of neuroimaging  and genetics is the goal of Imaging Genetics. Study of imaging and genetics individually has provided  important revelations regarding brain dysfunction; however, the new knowledge generated by their integration  holds considerable promise for improving diagnosis and treatment of mental illness. This conference proposal  supports an integrative forum facilitating the understanding of the biologically complex problem of mental  illness, individual differences, and the interplay among genetics, environment, and brain function.",83464,ZMH1,Special Emphasis Panel,,2,38474,
7756542,R15,DA,2,,01/15/2010,12/31/2011,PA-06-042,2R15DA021164-02,,NIDA:201000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,KENNESAW,UNITED STATES,SOCIAL SCIENCES,11,627758923,US,GA,301445591,KENNESAW STATE UNIVERSITY,"BOERI, MIRIAM W;",8342224;,2R15DA021164,06/01/2006,12/31/2011,"AIDS Virus; Academic Research Enhancement Awards; Academic Research Enhancement Awards (Area); Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Affect; Analysis, Data; Applications Grants; Area; Attention; Availability of Health Services; Awareness; Awarenesses; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bryophyta; Bryophyte; Care, Health; Communities; Crystal Meth; Data; Data Analyses; Data Collection; Deoxyephedrine; Desoxyephedrine; Drug usage; Drug user; Drugs; Educational Mainstreaming; Epidemiology; Face; Female; Focus Groups; Funding; Future; Gender; Gender Role; Goals; Grant Proposals; Grants, Applications; Group Interviews; HCV; HIV; HTLV-III; Health; Health Care Utilization; Health Services; Health Services Accessibility; Health Services Needs; Healthcare; Hepatitis C virus; Hepatitus C; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Intervention; Intervention Strategies; Interview; Interviews, Group; Investigation; Knowledge; LAV-HTLV-III; Life; Life Cycle; Life Cycle Stages; Literature; Lymphadenopathy-Associated Virus; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Medication; Methamphetamine; Methylamphetamine; Mosses; N-Methylamphetamine; NIDA; NIH; National Institute of Drug Abuse; National Institutes of Health; National Institutes of Health (U.S.); Needs, Health Services; Participant; Patient Self-Report; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Population Study; Public Health Service; Public Health Service (U.S.); R15 Mechanism; R15 Program; Recommendation; Recruitment Activity; Reporting; Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Risky Behavior; SAMHSA; STD; Sampling; Self-Report; Services; Sex Characteristics; Sex Differences; Sex Roles; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Social Environment; Societies; Stigmatization; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Time; Transmission; USPHS; United States National Institutes of Health; United States Public Health Service; United States Substance Abuse and Mental Health Services Administration; Venereal Diseases; Venereal Disorders; Venereal Infections; Violence; Virus-HIV; Woman; access to services; access to treatment; at risk behavior; availability of services; base; drug use; drug/agent; facial; follow-up; gender difference; health care availability; health care service; health care service access; health care service availability; health care service utilization; health services availability; health services utilization; healthcare access availability; healthcare service access; healthcare service availability; healthcare service utilization; healthcare utilization; interventional strategy; life course; longitudinal design; male; men; men's; neglect; novel; public health relevance; recruit; sexual dimorphism (noncellular); social; social climate; social context; socioenvironment; suburb; theories; transmission process; treatment utilization; trend; violent; violent behavior",Methamphetamine Use in the Suburbs: An Exploratory Study," Project Narrative/Relevance Epidemiological data show a steady increase in methamphetamine (MA) use and HIV-risk behaviors associated with MA use, and suburban women who use MA are an understudied and neglected population of drug users. This renewal study is an exploration of HIV-risk awareness, HIV-risk behaviors, healthcare utilization, and access to health services and treatment for suburban female MA users. The findings will yield recommendations for gender-specific and socially appropriate interventions at the individual and community levels.",21164,CIHB,Community Influences on Health Behavior,,2,201000,
7778411,R15,ES,2,,01/29/2010,12/31/2013,PA-06-042,2R15ES013128-02,,NIEHS:183283;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BATESVILLE,UNITED STATES,BIOLOGY,01,071248355,US,AR,72503,LYON COLLEGE,"LINDBLOM, TIM H;",6774928;,2R15ES013128,08/15/2004,12/31/2013,"Abscission; Affect; Animal Model; Animal Models and Related Studies; Animals; Autoregulation; Basal Metabolism; Basal metabolic rate; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Biology; C elegans; C.elegans; Caenorhabditis elegans; Carbohydrates; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chemistry; Chemistry, Biological; DNA Binding Domain; Diet Supplement; Dietary Supplements; Drug Metabolic Detoxication; Drug Prescribing; Drug Prescriptions; Drugs; Energy Expenditure; Energy Metabolism; Environment; Environmental Pollution; Enzymes; Event; Excision; Extirpation; Food; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genes, Reporter; Genomics; Goals; Health; High Throughput Assay; Homeostasis; Hormonal; Human; Human, General; Intermediary Metabolism; Intestinal; Intestines; Intracellular Communication and Signaling; Ligands; Link; Lipids; METBL; Man (Taxonomy); Man, Modern; Mediating; Medication; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Metabolism, Carbohydrates/Storage/Polysaccharides; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; NR1; NR1 gene; Nematoda; Nematodes; Nuclear Receptors; Nutritional Supplement; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiological Homeostasis; Physiology; Prescriptions, Drug; Production; Protein Motifs, DNA-Binding; Proteins; RNA; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Receptor Protein; Regulation; Removal; Reporter Genes; Research; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; Science of Chemistry; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; Surgical Removal; System; System, LOINC Axis 4; Targetings, Gene; Techniques; Toxin; Transcription Activation; Transcription Regulation; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Up-Regulation; Xenobiotic Metabolism; Xenobiotics; biological signal transduction; bowel; carbohydrate metabolism; cell type; chemotherapeutic agent; combinatorial; design; designing; detoxification; drinking; drug/agent; environmental contaminant; environmental contamination; gene product; high throughput screening; member; model organism; mutant; pathway; pollutant; public health relevance; receptor; receptor binding; resection; resistant; response; resting metabolic rate; reverse transcriptase PCR; roundworm; sensor; social role; systems research; tool; transcription factor",Combinatorial Control of Toxin Induced Gene Expression in C. elegans," This project is designed to discover how chemicals in food, drugs, and the environment impact human metabolism. Recent discoveries indicate a link between these chemicals and basic cellular functions such as energy metabolism and hormonal signaling. The research proposed in this project will help uncover the mechanisms that allow such foreign chemicals to have unexpected and deleterious consequences on human health.",13128,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,2,183283,
7780221,R15,EY,2,,02/01/2010,01/31/2013,PA-06-042,2R15EY013535-03,,NEI:158996;,2010,NATIONAL EYE INSTITUTE,,ASHLAND,UNITED STATES,BIOLOGY,16,076751825,US,OH,44805,ASHLAND UNIVERSITY,"POSNER, MASON ;",6066580;,2R15EY013535,08/01/2001,01/31/2013,"2 Dimensional Gel Electrophoresis; Affect; Analysis, Data; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Assay; Automobile Driving; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Biological Models; Biology; Blotting, Western; Brachydanio rerio; Cancers; Cataract; Cell Differentiation; Cell Differentiation process; Cells; Crystalline Lens; Crystallins; Danio rerio; Data; Data Analyses; Development; Disease; Disorder; Drivings, Automobile; Effectiveness; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Embryo; Embryonic; Experimental Designs; Eye; Eyeball; Future; GFP; Gene Expression Inhibitor; Genes, Reporter; Genetic Alteration; Genetic Change; Genetic defect; Genetically Engineered Mouse; Goals; Green Fluorescent Proteins; HSP; Heat shock proteins; High Throughput Assay; Histology; Homeostasis; Lead; Len, Crystalline; Len, Eye; Lens; Lens Fiber; Lens Proteins; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Methods and Techniques; Methods, Other; Mice; Model System; Modeling; Models, Biologic; Murine; Mus; Muscle; Muscle Tissue; Mutate; Mutation; NRVS-SYS; Nervous System; Nervous System Finding; Nervous System, Eye; Nervous system structure; Neuro-Ocular System; Neurologic Body System; Neurologic Finding; Neurologic Organ System; Neurological observations; Nucleic Acid Regulatory Sequences; Ocular Lens; Oligo; Oligonucleotides; Oligonucleotides, Antisense; Pb element; Physiologic; Physiological; Physiological Homeostasis; Play; Production; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Proteins; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Reporter Genes; Research Technics; Role; Screening procedure; Staging; Stress Proteins; Students; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Techniques; Techniques, Research; Technology; Testing; Time; Translations; Western Blotting; Western Blottings; Western Immunoblotting; Work; Zebra Danio; Zebra Fish; Zebrafish; alpha-Crystallins; cataractogenesis; cataractous lenses; disease/disorder; driving; experience; experiment; experimental research; experimental study; fiber cell; gene product; genetic manipulation; genetic promoter element; genetic regulatory element; genome mutation; heavy metal Pb; heavy metal lead; high throughput screening; human disease; in utero; in vivo; lens; lens transparency; malignancy; mouse development; neoplasm/cancer; novel; paralog; paralogous gene; protein blotting; protein expression; protein function; public health relevance; research study; screening; screenings; social role; tool; vision science",Alpha Crystallin Function in the Zebrafish, ¨-crystallin proteins are necessary for eye lens development and the maintenance of lens transparency. Mutations in these proteins and abnormal amounts are associated with multiple diseases of the eye and nervous system and found in various cancers. This project will use the zebrafish as a model species for examining the role of ¨-crystallins in lens development and the mechanisms that control their production.,13535,AED,Anterior Eye Disease Study Section,,3,158996,
7694494,R24,HL,2,,12/01/2009,11/30/2010,,2R24HL060808-10,,NHLBI:213000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW ORLEANS,UNITED STATES,PATHOLOGY,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"ZIESKE, ARTHUR W;",7594582;,2R24HL060808,08/01/1998,11/30/2010,"Abdominal aorta structure; Age; Age-Years; American Heart Association; Anatomic; Anatomical Sciences; Anatomy; Anterior; Aorta; Aorta, Abdominal; Apoplexy; Archives; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Authorization; Authorization documentation; Autopsy; Body Tissues; Cardiac artery; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chest; Communities; Coronary Disease; Coronary artery; Coronary heart disease; Country; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Environment; Fixatives; Freezing; Glass; Heart artery; Human; Human, General; Instruction; Investigators; Left; Legal; Lesion; Libraries; Louisiana; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Manuscripts; Medical; Methods; NIH; National Institutes of Health; National Institutes of Health (U.S.); Notification; Organ System, Cardiovascular; Permission; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Reporting; Research; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Right Coronary Artery; Right coronary artery structure; Risk Factors; Sampling; Schools, Medical; Science of Anatomy; Slide; Specimen; Staining method; Stainings; Stains; Streaks, Arterial Fatty; Stroke; Thorace; Thoracic; Thorax; Tissues; Trauma; United States; United States National Institutes of Health; Universities; Vascular Accident, Brain; Vascular, Heart; Youth; Youth 10-21; abdominal aorta; anatomy; atherogenesis; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; base; brain attack; cardiac disease risk; cardiac disorder risk; cerebral vascular accident; circulatory system; clinical data repository; clinical data warehouse; conference; cooperative study; coronary disorder; data repository; digital; heart disease risk; heart disorder risk; interest; medical schools; necropsy; novel; postmortem; programs; relational database; response; social; stroke; symposium; vulnerable plaque; web site",PDAY Cardiovascular Specimen and Data Library,,60808,ZHL1,Special Emphasis Panel,,10,213000,
7560423,R25,GM,2,,02/01/2010,01/31/2011,PAR-07-410,2R25GM048972-11,,NIGMS:345186;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,BIOLOGY,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"BAYLISS, FRANK T;",8445381;,2R25GM048972,09/30/1992,01/31/2015,"Address; Admission; Admission activity; Award; Biochemistry; Biology; Biomedical Research; California; Categories; Chemistry; Chemistry, Biological; Curriculum; Development; Discipline; Doctor of Pharmacy; Doctor of Philosophy; Education; Educational Curriculum; Educational aspects; Educational workshop; Enrollment; Ensure; Exposure to; Faculty; Future; Goals; Grant; Individual; Institution; Investigators; Journals; Knowledge; Lead; Magazine; Master's Degree; Measurable; Measures; Mentors; Minority; NIH; National Institutes of Health; National Institutes of Health (U.S.); Participant; Pb element; Peer Review; Performance; Ph.D.; PhD; Pharm.D.; PharmD; Preparation; Programs (PT); Programs [Publication Type]; Research; Research Personnel; Researchers; Route; San Francisco; Science; Science of Chemistry; Scientist; Students; Underrepresented Minority; United States National Institutes of Health; Universities; Workshop; Writing; career; conference; design; designing; enroll; experience; falls; graduate student; health disparities; health disparity; heavy metal Pb; heavy metal lead; interest; meetings; programs; skills; success; symposium; under-represented minority; underserved minority",Bridges to the Future,,48972,MPRC,Minority Programs Review Committee,,11,345186,
7761397,R25,GM,2,,02/01/2010,01/31/2011,PAR-07-411,2R25GM048998-11,,NIGMS:242345;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LAS CRUCES,UNITED STATES,CHEMISTRY,02,173851965,US,NM,880038002,NEW MEXICO STATE UNIVERSITY LAS CRUCES,"KUEHN, GLENN D;",1894200;,2R25GM048998,09/30/1992,01/31/2015,"Admission; Admission activity; Affect; American Indian; American Indians; Analysis, Data; Apache; Apache Indians; Area; Baccalaureate Degree; Bachelor's Degree; Basic Research; Basic Science; Behavioral Sciences; Biomedical Research; CCL7; CCL7 gene; Censuses; Chemistry; Chemistry, Organic; Cities; Colorado; Communities; Computer Programs; Computer software; Computers; Curriculum; Data Analyses; Development; Discipline; Educational Curriculum; Educational workshop; Enrollment; Ethics; Faculty; Funding; General Population; General Public; Goals; Grant; Home; Home environment; Indians, American; Information Retrieval; Institution; Instruction; Internships; Interview; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Life; MARC; MCP-3; MCP3; Mentors; Methods; Methods and Techniques; Methods, Other; NC28; Navaho; Navajo; New Mexico; Oral; Organic Chemistry; Participant; Population; Posters; Posters [Publication Type]; Preparation; Preparedness; Procedures; Programs (PT); Programs [Publication Type]; Readiness; Recruitment Activity; Reporting; Research; Research Activity; Retrieval, Data; SCYA7; Safety; Science; Science of Chemistry; Series; Software; Structure; Students; Techniques; Time; Training; Tribes; Universities; Visit; Work; Workshop; Writing; abstracting; base; career; cohort; college; computer program/software; enroll; experience; health disparities; health disparity; improved; instructor; lecturer; lectures; parity; posters; programs; public health relevance; recruit; residence; skills; tribal Nation; tribal communities; tribal community",BRIDGE TO THE BACCALAUREATE PROGRAM AT NEW MEXICO STATE UNIVERSITY," The purpose of this project is to increase the numbers of American Indian students from community colleges who pursue baccalaureate and graduate degrees in the biomedical and behavioral sciences. This group is under-represented at all levels in these disciplines and is disproportionately affected by health disparities. The project plan promotes inter- institutional partnerships among New Mexico State University in Las Cruces, NM, and three regional community colleges (Dine2 College, Shiprock; San Juan College, Farmington; University of New Mexico, Gallup) which are tribally, state, and locally controlled institutions, respectively. Combined, these institutions enroll at least 5,414 American Indian students. The overall programmatic goal is to apply well-integrated developmental activities based on student research internships that will increase student preparation and skills to successfully pursue the baccalaureate and graduate degrees in biomedical and behavioral sciences.",48998,ZGM1,Special Emphasis Panel,,11,242345,
7761108,R25,GM,2,,02/01/2010,01/31/2011,PAR-07-410,2R25GM054939-09A1,,NIGMS:233502;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,CHEMISTRY,32,066697590,US,CA,90032,CALIFORNIA STATE UNIVERSITY LOS ANGELES,"VELLANOWETH, ROBERT L;",1926557;,2R25GM054939,09/01/1996,01/31/2015,"Accounting; Achievement; Achievement Attainment; Admission; Admission activity; African American; Afro American; Afroamerican; American Indian; American Indians; Area; Award; Biochemistry; Biomedical Research; Black Populations; Black or African American; California; Chemistry; Chemistry, Biological; Communication; Communities; Discipline; Doctor of Philosophy; Enrollment; Environment; Ethnic and Racial Minorities; Faculty; Financial Support; Foundations; Goals; Grant; Health; Home; Home environment; Indians, American; Individual; Institution; Latino; Los Angeles; Master of Science; Measurable; Mentors; Minority; Minority Groups; Oral; Pacific Island Americans; Pacific Islander; Pacific Islander American; Ph.D.; PhD; Population; Process; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Records; Recruitment Activity; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Science; Science of Chemistry; Scientist; Series; Solutions; Students; Talents; Testing; Training; Universities; Update; Work; Writing; base; black American; career; catalyst; design; designing; enroll; health disparities; health disparity; improved; interest; meetings; member; minority health; programs; public health relevance; recruit; skills; success",Los Angeles Basin Bridges to the Ph.D. Program, Project Narrative The Los Angeles Basin Bridges to the Ph.D. Program will increase the numbers of doctoral-level scientists engaged in biomedical research to enhance the health of the US public. The Program focuses on members of US population segments that have traditionally been under-represented in the sciences. These individuals will be more likely to spend their careers working on health disparities specific to minority populations.,54939,MPRC,Minority Programs Review Committee,A1,9,233502,
7777733,R37,AR,2,,02/01/2010,01/31/2011,PA-07-070,2R37AR046523-12,,NIAMS:342000;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAINT LOUIS,UNITED STATES,PATHOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"TEITELBAUM, STEVEN L;",1868092;,2R37AR046523,02/01/2000,01/31/2015,"ASV; ASVSRC1; Address; Attention; Band 2 Protein; Bisphosphonates; Bone; Bone Resorption; Bone and Bones; Bones and Bone Tissue; CSF-1; CSF1; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Matrix; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Colony-Stimulating Factor 1; Cytoplasmic Domain; Cytoplasmic Tail; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Data; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Event; Exercise; Exercise, Physical; Extracellular Matrix, Integrins; Fracture; Fracture due to osteoporosis; Funding; Genes, c-fms; Genes, c-src; Grant; Inflammatory; Integrins; Intracellular Communication and Signaling; Ligands; M-CSF; MCSF; Macrophage Colony-Stimulating Factor; Mediating; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Osteoclastic Bone Loss; Osteolysis; Osteolytic; Osteoporosis; Osteoporosis with fracture; Osteoporotic fracture; Patients; Play; Receptor Protein; Rest; Risk; Role; SRC; SRC gene; SRC1; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Talin; Therapeutic; biological signal transduction; biphosphonate; bisphosphonate; bone; bone fracture; c fms; c src; c-fms Proto-Oncogenes; c-src Proto-Oncogenes; clinical investigation; conformation; conformational state; diphosphonate; disease/disorder; in vivo; intracellular skeleton; new therapeutic target; osteoporosis with pathological fracture; public health relevance; receptor; skeletal; social role; success; trial regimen; trial treatment; v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog",Mechanisms of AVB3 Integrin Mediated Bone Resorption," Project Narrative Most patients at risk for osteoporotic fractures are treated with bisphosphonates, which are increasingly associated with complications such as atypical fractures. The present grant, from its inception, has focused on discovering new therapeutic targets for these patients, specifically addressing molecules, known as integrins, which mediate the attachment of bone resorbing cells to skeletal matrix. The success of our efforts is underscored by the fact that integrin-targeting drugs are in clinical trial for the treatment of osteoporosis.",46523,SBSR,Skeletal Biology Structure and Regeneration Study Section,,12,342000,
7817719,R37,NS,2,,01/15/2010,11/30/2010,PA-07-070,2R37NS017813-29,,NINDS:344429;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WALTHAM,UNITED STATES,BIOLOGY,07,616845814,US,MA,024549110,BRANDEIS UNIVERSITY,"MARDER, EVE E;",1866710;,2R37NS017813,12/01/1981,11/30/2013,"Address; Agonist; Amines; Amino Acids; Antibodies; Attention; Behavior; Behavioral; Biological Neural Networks; Brain; Cell Communication and Signaling; Cell Signaling; Complement; Complement Proteins; Crustacea; Data; Dependence; Dysfunction; Encephalon; Encephalons; Family; Family member; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Frequencies (time pattern); Frequency; Functional disorder; Funding; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gases; Grant; Individual; Intracellular Communication and Signaling; Locomotion; MALD-MS; MALDI; MALDI-MS; Mass Spectrum; Mass Spectrum Analysis; Methods; Moods; Myxoid cyst; NRVS-SYS; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous System Diseases; Nervous System Physiology; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Ganglion; Neurocyte; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurologic function; Neurological Disorders; Neurological function; Neuromodulator; Neurons; Neuropeptides; Neurotransmitters; Operation; Operative Procedures; Operative Surgical Procedures; Pattern; Peptides; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiopathology; Play; Property; Property, LOINC Axis 2; Receptor Protein; Role; Sensory; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Specific qualifier value; Specified; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stomach; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; System; System, LOINC Axis 4; Time; V (voltage); Variant; Variation; Work; aminoacid; biological signal transduction; experiment; experimental research; experimental study; feeding; flexibility; fluorescent dye/probe; gastric; matrix assisted laser desorption ionization; member; nervous system disorder; nervous system function; neural control; neural network; neural regulation; neurological disease; neuronal; neuroregulation; pathophysiology; public health relevance; receptor; research study; response; social role; surgery; voltage",Neurotransmitter Modulation of Neuronal Circuits," Relevance Amines and neuropeptides are key to the function of the nervous system, and are important in controlling mood, attention, and changes in behavioral state in sleep, feeding, and locomotion. Despite their widespread importance, relatively little is known about the overall organization of neuromodulatory systems in behavior. The proposed work will reveal general principles relevant to neuromodulatory action.",17813,ZRG1,Special Emphasis Panel,,29,344429,
7781199,R37,NS,2,,01/18/2010,12/31/2010,PA-07-070,2R37NS040929-10,,NINDS:337969;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,PHYSIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"JAN, YUH NUNG;",6494978;,2R37NS040929,01/18/2001,12/31/2013,"Address; Affect; Afferent Neurons; Animals; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon; Biological Models; Brain; Cloning; Crossing Over; Crossing Over, Genetic; DISSEC; Defect; Dendrites; Development; Developmental Process; Dissection; Down Syndrome Cell Adhesion Molecule; Drosophila; Drosophila genus; EC 2.7; Employee Strikes; Encephalon; Encephalons; Family; Fruit Fly, Drosophila; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Crossing Over; Genetic Screening; Genetic defect; Goals; Golgi; Golgi Apparatus; Golgi Complex; Growth; Human; Human, General; Iceberg; Kanner's Syndrome; Kinases; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Mental disorders; Mental health disorders; Model System; Models, Biologic; Molecular; Morphogenesis; Movement; Mutation; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurons; Neurons, Afferent; Neurons, Sensory; Neurosciences; Pathology; Pathway interactions; Pattern; Peripheral Nervous System; Phosphotransferases; Polycomb; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Psychiatric Disease; Psychiatric Disorder; Regulation; Reports, Progress; Role; Secretory Component; Secretory Piece; Sensory; Sensory Cell Afferent Neuron; Shapes; Signal Transduction Pathway; Strikes; Strikes, Employee; Synapses; Synaptic; Testing; Tissue Growth; Transphosphorylases; Transport Piece; Tumor Suppressor Proteins; Unspecified Mental Disorder; Work; axon growth; axon growth cone guidance; axon guidance; axonal growth; base; body movement; design; designing; fruit fly; genome mutation; insight; interest; mental illness; mutant; nervous system disorder; neural circuit; neural circuitry; neurological disease; neuronal; nonsister chromatid exchange; novel; ontogeny; pathway; programs; psychological disorder; public health relevance; social role; spatial relationship; success; trafficking; tumor suppressor",Genetic Dissection of Dendrite Development," Project Narrative This project aims to elucidate the molecular mechanisms that control dendrite development by using Drosophila sensory neurons as a model system. Given there is already strong evidence that many molecular mechanisms that control dendrite development are evolutionarily conserved, this work is likely to contribute to the understanding and eventual treatment of human neurological disorders, many of which have pathology in dendrites.",40929,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,10,337969,
7803950,R44,AI,2,,02/01/2010,01/31/2011,PA-09-080,2R44AI075739-02,,NIAID:949182;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SYRACUSE,UNITED STATES,,25,138843722,US,NY,132444100,"ORTHOSYSTEMS, INC.","BORER, PHILIP N;",1947082;,2R44AI075739,07/01/2007,01/31/2012,"Affinity; Antibodies; Aptamer Technology; Assay; Bacteria; Base Sequence; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biologic Warfare; Biological Assay; Biological Warfare; Biosensing Technics; Biosensing Techniques; Biosensor; Blood; Blood Coagulation Factor IX, Activated; Blood Plasma; Cell Communication and Signaling; Cell Signaling; Cell surface; Clotting; Coagulation; Coagulation Factor IXa; Coagulation Process; Contracting Opportunities; Contracts; Custom; DNA; DNA Library; DNA bank; Deoxyribonucleic Acid; Detection; Diagnostic; Disease; Disorder; Drugs; Engineering; Engineerings; Enzymes; Evolution; Factor IX, Activated; Factor IXa; Food Safety; GFAC; Gene Probes, RNA; Gene Products, RNA; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hexoses; High Throughput Assay; Human; Human, General; Hydrolysis; Image; In Vitro; Intracellular Communication and Signaling; Investigators; Legal patent; Length; Libraries; Licensing; Man (Taxonomy); Man, Modern; Marketing; Measures; Medication; Methods; Microarray Analysis; Microarray-Based Analysis; Molecular Biology, Nucleic Acid Sequencing; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Nucleic Acids; Nucleic acid sequencing; Nucleotide Sequence; Nucleotides; Organism; Patents; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Pill; Plasma; Proteins; RNA; RNA Probes; RNA Sequences; RNA, Non-Polyadenylated; Randomized; Reagent; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; SBIR; SBIRS (R43/44); Sampling; Screening procedure; Sequences, RNA; Serum, Plasma; Services; Signal Transduction; Signal Transduction Systems; Signaling; Small Business Innovation Research; Small Business Innovation Research Grant; Specificity; Structure; Surface Plasmon Resonance; Technology; Therapeutic; Thrombosis; Virus; Viruses, General; Wound Healing; Wound Repair; angiogenesis; aptamer; base; biological signal transduction; biosensing; biowarfare; commercial application; commercialization; conformation; conformational state; cost; cross reactivity; design; designing; disease/disorder; drug candidate; drug discovery; drug/agent; enzyme activity; gene product; high throughput screening; imaging; inhibitor; inhibitor/antagonist; interest; living system; luminescence; member; microarray technology; next generation; nuclease; nucleic acid sequence; pathogen; pill (pharmacologic); public health relevance; randomisation; randomization; randomly assigned; resistant; response; screening; screenings; sensor; sensor (biological); single molecule; small molecule; stem; sugar; synthetic DNA; synthetic construct; tissue repair; water quality; waterborne",Simple DNA/RNA Probes for Protein Targets," Narrative  We present an integrated approach for rapid discovery of small, structurally defined nucleic acid ""HT- aptamer"" sequences that bind with high affinity and selectivity to proteins and other targets. The approach will be used to create sensors to discover small molecules as candidates for drugs against selected protein targets involved in wound healing and thrombosis. Beyond this project, discovery of high affinity HT-aptamers will be used in detecting waterborne pathogens, biological warfare agents, and diagnostic applications with costs ex- pected to be reduced by a factor of ten or more compared to antibody-based reagents.",75739,ZRG1,Special Emphasis Panel,,2,949182,
7800652,R44,AR,2,,02/01/2010,01/31/2011,PA-09-080,2R44AR055014-02A1,,NIAMS:408461;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,Georgetown,UNITED STATES,,31,602492451,US,TX,786268201,"ORTHOPEUTICS, LP","HEDMAN, THOMAS P;",6579318;,2R44AR055014,08/15/2007,01/31/2012,"Acute; Address; Age; Animal Model; Animal Models and Related Studies; Animals; Articulation; Assay; Back Ache; Back Pain; Backache; Bifunctional Reagents; Bioassay; Biologic Assays; Biological Assay; Blood Chemical Analysis; Body Tissues; Bovine Species; Buffers; Cattle; Cell-Extracellular Matrix; Chemical Analyses, Blood; Chemicals; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collagen; Common Rat Strains; Cross-Linking Reagents; Crosslinker; Crosslinking Reagents; Data; Digestion; Disease; Disorder; Drug Formulations; Drugs; ECM; Effectiveness; Esteroproteases; Extracellular Matrix; Fatigue; Fibrosis; Formulation; Formulations, Drug; Funding; Future; Goals; HPLC; Health; High Pressure Liquid Chromatography; Human; Human, General; In Vitro; Injectable; Injection of therapeutic agent; Injections; Injections, Subcutaneous; Intervertebral Disc Degenerative Disease; Intervertebral Disc Degenerative Disorder; Intervertebral Disk; Intervertebral disc structure; Investigation; Joints; Kinetic; Kinetics; Lack of Energy; Living Wills; Low Back Ache; Low Back Pain; Low Backache; Lumbago; Mammals, Rats; Man (Taxonomy); Man, Modern; Mechanics; Medication; Modeling; Modification; Neurologic; Neurological; Nutritional; Operation; Operative Procedures; Operative Surgical Procedures; Penetration; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Play; Preparation; Prevalence; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; Rat; Rattus; Reaction; Reagent; Research; Resistance; Role; SBIR; SBIRS (R43/44); SUBGP; Small Business Innovation Research; Small Business Innovation Research Grant; Societies; Solutions; Spinal; Structure; Subcutaneous Injections; Subgroup; Surgical; Surgical Interventions; Surgical Procedure; Testing; Tissues; Variant; Variation; aged; base; biocompatibility; biomaterial compatibility; blood chemistry; bovid; bovine; clinical care; clinical investigation; conditioning; cost; cow; cross-link; crosslink; design; designing; disability; disease/disorder; drug/agent; effective therapy; efficacy testing; improved; in vitro Assay; in vivo; intervertebral disk degeneration; model organism; neuron toxicity; neuronal toxicity; neurotoxicity; novel; pandemic; pandemic disease; patient population; peer; prevent; preventing; programs; public health relevance; reaction rate; resistant; response; social role; success; surfactant; surgery; treatment effect",Injectable collagen crosslink augmentation for degenerative disc disease,"  Back pain and disability associated with spinal degeneration and instability remains among the most costly and prevalent health problems in the US today. With a patient population in excess of 15 million/year, the societal cost is estimated to be in the realm of $100 billion/year. Due to the limited success of current treatment options, it is reasonable to expect that an effective nonsurgical solution could revolutionize clinical care for this pandemic.  ",55014,ZRG1,Special Emphasis Panel,A1,2,408461,
7801494,R44,AT,2,,02/01/2010,01/31/2011,PA-09-080,2R44AT004534-02,,NCCAM:364290;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,CHICAGO,UNITED STATES,,05,780458142,US,IL,60614,WRIGHTWOOD TECHNOLOGIES INC.,"PAULI, GUIDO F;PRO, SAMUEL MICHAEL (contact);",7025628;8706095 (contact);,2R44AT004534,02/01/2010,01/31/2012,"Analysis, Data; Area; Automation; Biochemical; Biological Factors; Botanicals; CCC; Characteristics; Chemicals; Complex; Consumption; Countercurrent Distribution; Data; Data Analyses; Development; Diet Supplement; Dietary Supplements; Disease; Disorder; Environment; Factor, Biologic; Feedback; Future; Goals; IT Systems; Information Systems; Information Technology Systems; Investigators; Journal Article; Journal Article (PT); Journal Article [Publication Type]; Knowledge; Liquid substance; Location; Measurement; Measures; Methods and Techniques; Methods, Other; Minor; Modeling; Monitor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Nature; Nutritional Supplement; Partition Coefficient; Performance; Phase; Position; Positioning Attribute; Process; Property; Property, LOINC Axis 2; Recovery; Research; Research Personnel; Research Proposals; Researchers; Retrieval; Running; SBIR; SBIRS (R43/44); Sampling; Small Business Innovation Research; Small Business Innovation Research Grant; Solid; Solvents; System; System, LOINC Axis 4; Systems, Data; Techniques; Technology; Time; Training; Tuberculosis; United States National Institutes of Health; base; chemical property; combat; countercurrent; countercurrent chromatography; data acquisition; disease/disorder; disseminated TB; disseminated tuberculosis; empowered; experience; fight against; fluid; human disease; instrument; journal article; liquid; meter; multidisciplinary; prevent; preventing; prototype; public health relevance; sensor; success; tool; tuberculous spondyloarthropathy; virtual",Automated technology for purification of active ingredients in natural products," Project Narrative The analysis of highly complex chemical mixtures presents a significant scientific challenge, particularly in biomedical studies involving natural products and other complex biogenic samples. Countercurrent chromatography (CCC) is a technique, originally developed at NIH, which is able to solve many challenges in this area. This SBIR research proposal provides the key piece of technology required to bring the immense potential of CCC's analytical capabilities to realization, empowering biomedical researchers with a much- needed new tool in the arsenal to combat disease through biochemical discovery.",4534,ZRG1,Special Emphasis Panel,,2,364290,
7805102,R44,EB,2,,02/01/2010,01/31/2011,PA-09-100,2R44EB007421-02,,NIBIB:289317;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,TUCSON,UNITED STATES,,08,151525248,US,AZ,85750,"PIEZO ENERGY TECHNOLOGIES, LLC","RADZIEMSKI, LEON ;",8593817;,2R44EB007421,06/01/2007,09/30/2011,"Acute; Advanced Development; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Area; Biocompatible; Biocompatible Materials; Biomaterials; Body Tissues; CDC; Care, Health; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of life; Charge; Compliance behavior; Contracting Opportunities; Contracts; Crossmatching, Tissue; Death; Defibrillators; Development; Development and Research; Devices; Diagnosis, Ultrasound; Diagnostic; Distress; Echography; Echotomography; Effectiveness; Electric Shock Cardiac Stimulators; Electromagnetic; Electromagnetics; Electronics; Ensure; Evaluation; Exposure to; Family suidae; Fostering; Foundations; Frequencies (time pattern); Frequency; Funding; Generalized Growth; Goals; Government; Growth; Guidelines; Head and Neck, Pharynx; Health; Health Care Costs; Health Care Industry; Health Costs; Healthcare; Healthcare Costs; Healthcare Industry; Heating; Histocompatibility Testing; Human; Human, General; Idiopathic Parkinson Disease; Implant; In Vitro; Industry, Healthcare; Infection; Intellectual Property; Lead; Legal patent; Length of Life; Length of Stay; Letters; Lewy Body Parkinson Disease; Licensing; Longevity; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Manufacturer; Manufacturer Name; Marketing; Measurement; Medical Device; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Metals; Methods; Methods and Techniques; Methods, Other; Mission; Modeling; Monitor; Muscle; Muscle Tissue; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Nuclear Magnetic Resonance Imaging; Number of Days in Hospital; Operation; Operative Procedures; Operative Surgical Procedures; Output; Pace Stimulators; Pacemakers; Pain; Pain Control; Pain Therapy; Pain management; Painful; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patents; Patient Compliance; Patient Cooperation; Patients; Pb element; Persons; Pharyngeal structure; Pharynx; Pharynxs; Phase; Physics; Pigs; Plant Embryos; Power Sources; Power Supplies; Pressure; Pressure- physical agent; Primary Parkinsonism; Procedures; Production; Proliferating; Public Health; R & D; R&D; Radio; Regulation; Research Design; SCHED; Safety; Schedule; Seeds; Site; Staging; Stimulators, Electrical, Cardiac, Shock; Stimulators, Electrical, Pace; Stomach; Study Type; Suidae; Surgical; Surgical Interventions; Surgical Procedure; Swine; Symptoms; System; System, LOINC Axis 4; Techniques; Technology; Temperature; Temperature Sense; Testing; Therapeutic; Throat; Time; TimeLine; Tissue Crossmatchings; Tissue Growth; Tissue Typing; Tissues; Transmission; Treatment Compliance; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Urinary tract; Weight; Wireless Technology; Zeugmatography; Zygotes, Plant; analgesia; awake; base; biomedical implant; chemotherapy; compliance cooperation; cost; design; design and construction; designing; diagnostic ultrasound; experiment; experimental research; experimental study; gastric; heart function; heavy metal Pb; heavy metal lead; histocompatibility typing; hospital days; hospital length of stay; hospital stay; human tissue; implant device; implantable device; implanted sensor; improved; in vivo; indwelling device; innovate; innovation; innovative; interest; life span; lifespan; miniaturize; nano; next generation; novel; ontogeny; patient adherence; porcine; pressure; prototype; public health medicine (field); public health relevance; research and development; research study; safety study; seed; sensor; simulation; sonogram; sonography; sound measurement; study design; suid; surgery; therapy compliance; therapy cooperation; thermoreception; transmission process; ultrasound; ultrasound imaging; ultrasound scanning; wireless",Wireless power transmission to implanted devices," Project Narrative: Relevance  This new wireless recharging technique will result in increased longevity and capability of implanted battieries and will advance several public health goals by: 1) alleviating distress, pain, complications and cost by reducing the number of battery replacement operations, 2) increasing functionality of the implant by providing more power for diagnostic output or burst mode operation, 3) improving patient compliance.",7421,ZRG1,Special Emphasis Panel,,2,289317,
7801723,R44,EY,2,,02/01/2010,01/31/2011,PA-09-080,2R44EY018025-02,,NEI:602760;,2010,NATIONAL EYE INSTITUTE,,PITTSBURGH,UNITED STATES,,04,151391174,US,PA,152382920,"NEURO KINETICS, INC.","KIDERMAN, ALEXANDER D;",7986466;,2R44EY018025,03/01/2007,01/31/2012,"Academy; Advocate; Affect; Age; Agreement; American; Area; Artifacts; Automatic Data Processing; Autonomic Dysfunction; Back; Bleeding; Blindness; Blood Vessels; Caliber; Caring; Cataract; Categories; Cicatrix; Clinical; Clinical Evaluation; Clinical Protocols; Clinical Research; Clinical Study; Clinical Testing; Cognitive Discrimination; Complications of Diabetes Mellitus; Computer Data Processing; Computer Programs; Computer software; Data; Data Quality; Detection; Development; Development Plans; Devices; Diabetes Complications; Diabetes Mellitus; Diabetes-Related Complications; Diabetic Complications; Diabetic Retinopathy; Diagnosis; Diameter; Discrimination; Discrimination (Psychology); Disease; Disorder; Dorsum; Drugs; Early Diagnosis; Electronic Data Processing; Ethics Committees, Research; Evaluation; Exclusion; Eye; Eye Exam; Eye Examination; Eyeball; Feedback; Forecast of outcome; Frequencies (time pattern); Frequency; Generalized Growth; Goals; Growth; Guidelines; Hemorrhage; IRBs; Image; Imaging Device; Imaging Tool; Individual; Institutional Review Boards; Intervention; Intervention Strategies; Ischemia; Kinetic; Kinetics; Light; Measures; Medical Specialities; Medication; Method LOINC Axis 6; Methodology; Methods; Modeling; Morphologic artifacts; Ophthalmic examination and evaluation; Ophthalmology; Outcome; Patients; Pattern; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Photography; Photoradiation; Plans, Development; Population; Production; Prognosis; Protocol; Protocols documentation; Pupil; QOL; Quality of life; Quality, Data; Reading; Records Controls; Reporting; Research Ethics Committees; Research Subjects; Retina; Retinal Diseases; Retinal Disorder; Risk; Running; SBIR; SBIRS (R43/44); Scars; Screening procedure; Sensitivity and Specificity; Severity of illness; Sight; Small Business Innovation Research; Small Business Innovation Research Grant; Software; Specialties, Medical; Specialty; Staging; Stimulus; System; System, LOINC Axis 4; Technology; Test Result; Testing; Therapeutic Intervention; Tissue Growth; Translating; Translatings; Treatment Cost; Vision; Work; automated data processing; base; blood loss; care delivery; cataractogenesis; cataractous lenses; clinical test; computer program/software; constriction; delivery of care; diabetes; diabetes management; diabetic; disease severity; disease/disorder; drug/agent; early detection; imaging; improved; instrument; intervention therapy; interventional strategy; language translation; medical specialties; meetings; ontogeny; outcome forecast; phase 1 study; prevent; preventing; public health relevance; research clinical testing; response; retina disease; retina disorder; retina ischemia; retinal damage; retinal ischemia; retinopathy; screening; screenings; tool; vascular",Developing a Noninvasive Method and Device for Assessing the Degree of Midperiphe," Project Narrative According to the American Academy of Ophthalmology, Diabetic Retinopathy is the leading cause of blindness among working Americans and currently affects nearly seven million people in the U.S. There is widespread agreement that the current U.S. eye care delivery system cannot meet the screening needs of these patients by relying on traditional, clinical eye examinations. Neuro Kinetics is developing a rapid, noninvasive screening technology based on images of the pupil's response to unique patterns of light to detect retinal damage from diabetes at a stage that would warrant intervention and therapy to protect sight.",18025,ZRG1,Special Emphasis Panel,,2,602760,
7804744,R44,GM,2,,01/15/2010,01/14/2011,PA-09-080,2R44GM079888-02,,NIGMS:537002;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBIA,UNITED STATES,,02,045600368,US,SC,292294339,"DOTY SCIENTIFIC, INC.","DOTY, FRANCIS DAVID;",2431263;,2R44GM079888,04/01/2007,01/14/2012,"Antiheparin Factor; Biological; Biological Function; Biological Process; Blood Platelet Factor IV; Blood platelet factor 4; Cell Communication and Signaling; Cell Signaling; Chemokine (C-X-C motif) Ligand 4; Compensation; Complex; Crystallographies; Crystallography; Development; Effectiveness; Equipment; Factor 4; Faculty; Financial compensation; Florida; Frequencies (time pattern); Frequency; Funding; Goals; Heating; Heparin Neutralizing Protein; Home; Home environment; Human Figure; Human body; Intracellular Communication and Signaling; Investigators; Laboratories; Lanthanides; Lanthanoid Series Elements; Lanthanoids; Macromolecular Structure; Magic; Magnetic Resonance; Magnetism; Medical; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Molecular Structure; NMR Spectroscopy; Noise; Nuclear Magnetic Resonance; Operation; Operative Procedures; Operative Surgical Procedures; Performance; Phase; Physiologic pulse; Platelet Factor 4; Proteins; Publishing; Pulse; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Recombinant Platelet Factor 4; Research; Research Personnel; Researchers; Resolution; Roentgen Rays; Sales; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Solid; Solutions; Solvents; Spectroscopy, NMR; Structure; Surface Proteins; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Temperature; Testing; Time; Voice; Width; Work; X-Radiation; X-Rays; Xrays; base; biological signal transduction; cold temperature; cost; design; designing; experiment; experimental research; experimental study; formamide; gamma-Thromboglobulin; gene product; improved; interest; low temperature; macromolecule; magnetic; magnetic field; membrane structure; new technology; nuclear magnetic resonance spectroscopy; platelet factor IV; prototype; public health relevance; research study; simulation; success; surgery",An Ultra-High-Power H/C/N NMR Probe for Membrane Proteins," An Ultra-High-Power H/C/N NMR Probe for Membrane Proteins PI: F. David Doty General Narrative: There is strong medical and scientific interest in determining the structures of the 15,000 membrane proteins in the human body over the next decade, though available NMR and X-ray methods work poorly and have yielded only a few such structures over the past decade. There are more than 5,000 high-field NMR systems installed world-wide, and annual NMR equipment sales are currently ~$300M. The proposed ultra-high-power NMR probe development is expected to enhance the ability to determine molecular structures of large, insolu- ble, membrane proteins by advanced NMR methods by an order of magnitude in many cases.",79888,ZRG1,Special Emphasis Panel,,2,537002,
7804021,R44,GM,2,,02/01/2010,01/31/2011,PA-09-080,2R44GM085860-02,,NIGMS:361415;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN DIEGO,UNITED STATES,,50,945720043,US,CA,921212911,"TRILINK BIOTECHNOLOGIES, INC.","PAUL, NATASHA ;",8621219;,2R44GM085860,07/07/2008,01/31/2012,"Amino Acids; Amino Sugars; Base Pairing; Base Sequence; Biological; Biotechnology; Buffers; Charge; Chemicals; Closure by Ligation; Cognitive Discrimination; DNA; DNA Joinases; DNA Ligases; DNA Molecular Biology; Deoxyribonucleic Acid; Detection; Diagnostic; Discrimination; Discrimination (Psychology); E coli; Effectiveness; Enzymes; Escherichia coli; Evaluation; Foundations; Generations; Goals; Government; Hydroxyl; Hydroxyl Radical; Investigation; Lead; Ligase; Ligase, T4 DNA; Ligation; Location; Marketing; Measures; Modification; Molecular; Molecular Biology; Nucleic Acids; Nucleotide Sequence; Nucleotides; Oligo; Oligonucleotides; Pb element; Performance; Persons; Phase; Phosphates; Point Mutation; Polydeoxyribonucleotide Ligases; Polydeoxyribonucleotide Synthetases; Polymorphism Analysis; Polymorphism Detection; Polymorphism, Single Base; Position; Positioning Attribute; Proteins; Reaction; Role; Running; SNP; SNPs; Series; Side; Single Nucleotide Polymorphism; Source; Specificity; Spinal Column; Spine; Structure-Activity Relationship; Synthetases; T4 DNA Ligase; Testing; Variant; Variation; Vertebral column; Work; adenylate; alpha-thio-ATP; alpha-thioadenosine triphosphate; aminoacid; aminosugar; analog; backbone; base; chemical structure function; cofactor; commercialization; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; improved; inorganic phosphate; methylphosphonate; new approaches; next generation; novel; novel approaches; novel strategies; novel strategy; nucleic acid sequence; phase 1 study; phase 2 study; phosphodiester; phosphonate; phosphorothioate; public health relevance; research study; social role; structure function relationship; success; sugar; technology development; tool",Chemical Determinants of DNA Ligase Fidelity," Project Narrative The field of molecular diagnostics is a growing market with a current estimated value of $20.5 billion. One key class of enzymes that are used in these efforts is the DNA dependent DNA ligases. To further improve the accuracy of the DNA joining reaction catalyzed by DNA ligases, we propose the investigation of chemically modified components.",85860,ZRG1,Special Emphasis Panel,,2,361415,
7804100,R44,GM,2,,02/10/2010,01/31/2011,PA-09-080,2R44GM085863-02,,NIGMS:460941;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CORVALVILLE,UNITED STATES,,02,001988919,US,IA,52241,"INTEGRATED DNA TECHNOLOGIES, INC.","BEHLKE, MARK AARON;",8495252;,2R44GM085863,08/15/2008,01/31/2012,"3' Untranslated Regions; 3'UTR; Adoption; Affect; Algorithms; Alternate Splicing; Alternative Splicing; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Base Pairing; Biologic Phenomena; Biological Phenomena; Biology; Chemicals; Chemistry; Communities; Complex; Criteria, Selection; Cultured Cells; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data Set; Dataset; Development; Disease Progression; Endoribonuclease H; Endoribonuclease H (Calf Thymus); Exons; Fingerprint; GWAS; Gene Action Regulation; Gene Expression; Gene Expression Inhibitor; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Targeting; Genes; Genes, Regulator; Genome; Goals; Human; Human, General; In element; Indium; Intervening Sequences; Introns; Investigation; Length; Man (Taxonomy); Man, Modern; Measures; Mediating; Messenger RNA; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Modification; Oligo; Oligonucleotides; Oligonucleotides, Antisense; Pathway interactions; Pattern; Phase; Polyadenylation; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pre-mRNA; Precursor RNA; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Publications; Publishing; Quelling; RNA Interference; RNA Polyadenylation; RNA Silencing; RNA Silencings; RNA Splicing, Alternative; RNA, Messenger; RNA, Messenger, Precursors; RNA, Small Interfering; RNAi; RNase H; Reagent; Refractory; Regulator Genes; Reports, Progress; Research; Resistance; Ribonuclease H; Ribonuclease H, Calf Thymus; SBIR; SBIRS (R43/44); Science of Chemistry; Scientific Publication; Scientist; Selection Criteria; Sequence-Specific Posttranscriptional Gene Silencing; Site; Small Business Innovation Research; Small Business Innovation Research Grant; Small Interfering RNA; Specificity; Tail; Targetings, Gene; Techniques; Technology; Testing; To specify; Transcript; Transcriptional Regulatory Elements; Transfection; Translations; U1 RNA; U1 small nuclear RNA; U1 snRNA; UTRs; Untranslated Regions; Walking; Work; base; commercialization; design; designing; experiment; experimental research; experimental study; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; high throughput analysis; improved; knock-down; mRNA; mRNA Precursor; microarray technology; new technology; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathway; potency testing; premRNA; programs; public health relevance; regulatory gene; research study; resistant; response; siRNA; success; tool; trans acting element; whole genome association studies; whole genome association study",Optimization of U1 Adaptor Technology," PROJECT NARRATIVE The commercialization of this new U1 Adaptor mediated gene silencing technology will be a significant addition to the scientific research community's ""gene silencing toolkit"". Because this method exploits a distinctly different mechanism compared to more common gene silencing approaches, it has the potential of enhancing these traditional technologies when used in combination with them via additive effects. This may aid in the development of emerging oligonucleotide-based gene silencing therapies by improving sensitivity and efficacy.",85863,ZRG1,Special Emphasis Panel,,2,460941,
7760204,R44,NS,2,,01/18/2010,12/31/2010,PAR-08-202,2R44NS053155-02,,NINDS:370634;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN DIEGO,UNITED STATES,,53,786192120,US,CA,921021946,"SOURCE SIGNAL IMAGING, INC.","PFLIEGER, MARK E;",1963170;,2R44NS053155,07/01/2005,12/31/2011,"Address; Algorithms; Auditory; Behavioral; Behavioral Paradigm; Biological Models; Brain; Cell Communication and Signaling; Cell Signaling; Characteristics; Clinical; Code; Coding System; Cognitive; Complex; Computer Analysis; Computer Programs; Computer Software Development; Computer Software Engineering; Computer Software Tools; Computer software; Data; Dependence; Development; Development Plans; Diagnostic tests; EEG; Electroencephalography; Electromagnetic; Electromagnetics; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Engineering, Software; Event; Event-Related Potentials; Experimental Designs; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Graphical interface; Human; Human, General; Imagery; Intracellular Communication and Signaling; Investigators; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Masks; Measures; Memory; Model System; Modeling; Models, Biologic; Modification; Motor; Movement; Nervous System, Brain; Neurophysiology / Electrophysiology; Neurosciences; Phase; Pilot Projects; Plans, Development; Process; Protocol; Protocols documentation; Psychological Refractory Period; Reaction Time; Recovery of Function; Refractory Period, Psychologic; Refractory Period, Psychological; Research; Research Personnel; Researchers; Response RT; Response Time; SBIR; SBIRS (R43/44); Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Small Business Innovation Research; Small Business Innovation Research Grant; Software; Software Engineering; Software Tools; Source; Stimulus; System; System, LOINC Axis 4; Time; Tools, Software; Variant; Variation; Visual; Visualization; abstracting; base; biological signal transduction; biomarker; body movement; clinical significance; clinically significant; cognitive neuroscience; computational analysis; computational tools; computer program/software; computerized tools; data modeling; dementia praecox; design; designing; encephalography; event related potential; fMRI; functional recovery; graphic user interface; graphical user interface; improved; innovate; innovation; innovative; magnetic field; multisensory; neurophysiology; neuropsychiatric; neuropsychiatry; novel; pilot study; prototype; psychomotor reaction time; public health relevance; response; schizophrenic; sensory gating; theories; tool",System Identification Software for Cognitive Electrophysiology," Project Narrative Cognitive-behavioral neuroscientists lack adequate computational tools for identifying linear and nonlinear dynamical system models, from human electrophysiological data, making it difficult or impossible to investigate systematically many scientifically and clinically significant phenomena, including response suppression or facilitation, recovery functions, sensory gating, echoic memory lifetimes, and priming. Commercial software tools to be developed under this SBIR project will enable cognitive-behavioral neurophysiologists to characterize these modulations of variable event-related transients. The software will be validated using simulated and experimental data, including a pilot study that will lay the basis for identifying candidate biomarkers for schizophrenia research.",53155,ZRG1,Special Emphasis Panel,,2,370634,
8002410,R56,DK,2,Y,02/01/2010,01/31/2011,PA-07-070,2R56DK041431-19A1,,NIDDK:235500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,PHARMACOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"SKIDGEL, RANDAL A;",1866378;,2R56DK041431,07/01/1997,01/31/2011,,Structure and Function of Carboxypeptidases,,41431,MIST,Molecular and Integrative Signal Transduction Study Section,A1,19,235500,
8002411,R56,DK,2,Y,02/01/2010,01/31/2011,PA-07-070,2R56DK056796-10,,NIDDK:219750;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,PHYSIOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"KIRK, KEVIN L;",1872745;,2R56DK056796,12/01/1999,01/31/2011,,New paradigms of CFTR regulation,,56796,ZRG1,Special Emphasis Panel,,10,219750,
8002418,R56,DK,2,Y,02/01/2010,01/31/2011,PA-07-070,2R56DK057080-10,,NIDDK:219750;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GAINESVILLE,UNITED STATES,PHARMACOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"HASKELL-LUEVANO, CARRIE ;",7715836;,2R56DK057080,07/01/1999,01/31/2011,,Structural Determinants of Neuroendocrine Receptors,,57080,ZRG1,Special Emphasis Panel,,10,219750,
8002432,R56,DK,2,Y,01/19/2010,12/31/2010,PA-07-070,2R56DK070636-06,,NIDDK:235500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"JENSEN, JAN ;",7845068;,2R56DK070636,04/01/2005,12/31/2010,,Molecular mechanism of FGF10 signaling in pancreatic development,,70636,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,6,235500,
7849192,T32,EY,2,,01/01/2010,12/31/2010,,2T32EY007132-18A1,,NEI:181316;,2010,NATIONAL EYE INSTITUTE,,GAINESVILLE,UNITED STATES,OPHTHALMOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"SMITH, W CLAY;",1911524;,2T32EY007132,09/30/1991,12/31/2014,Research Training; vision science,Research Training in Vision Science,,7132,ZEY1,Special Emphasis Panel,A1,18,181316,
7688208,T36,GM,2,,02/01/2010,01/31/2011,PAR-08-118,2T36GM008742-12,,NIGMS:446500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WASHINGTON,UNITED STATES,,00,804328826,US,DC,20008,NATIONAL INSTITUTE OF SCIENCE,"COUSIN, CAROLYN EVANS;",9582366;,2T36GM008742,05/01/1999,01/31/2015,"Address; Administrator; Adopted; African American; Afro American; Afroamerican; Articulation; Award; BRO; Black Populations; Black or African American; Brothers; Caliber; Communities; Community Networks; Data; Diameter; Discipline; Educational workshop; Engineering; Engineerings; Event; Exhibits; Faculty; Foundations; Funding; Future; Generalized Growth; Gifts; Goals; Grant; Growth; HBCUs; Hand; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Hispanic Populations; Hispanics; Hispanics or Latinos; Historically Black Colleges; Historically Black Colleges and Universities; Historically Black Institution; Individual; Institutes; Institution; Intervention; Intervention Strategies; Joints; Latino Population; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Marketing; Mathematics; Mediation; Methods; Minority; NIGMS; NIH; National Institute of General Medical Sciences; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Participant; Plant Embryos; Population; Posters; Posters [Publication Type]; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Resources; Resources; SIS; Schools; Science; Science Enrichment; Scientist; Seeds; Series; Sister; Societies; Source; Spanish Origin; Students; Technology; Time; Tissue Growth; Training; Travel; United States National Institutes of Health; Universities; Validation; Woman; Work; Workshop; Zygotes, Plant; base; black American; career; conference; cost; design; designing; expectation; experience; forging; graduate student; high school; hispanic community; improved; interest; interventional strategy; lecturer; lectures; meetings; ontogeny; peer; posters; prevent; preventing; programs; response; role model; seed; success; symposium; volunteer","Increasing Minority Student Participation at the NIS, BKX Joint Annual Meetings",,8742,MPRC,Minority Programs Review Committee,,12,446500,
7812734,U10,HD,2,,02/01/2010,12/31/2010,HD-09-002,2U10HD047891-06,,NICHD:1007037;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,GALVESTON,UNITED STATES,OBSTETRICS & GYNECOLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"AHMED, MAHMOUD S;HANKINS, GARY D (contact);",1967872;1978104 (contact);,2U10HD047891,07/01/2004,12/31/2014,"21+ years old; Adult; Affect; Alternative Therapies; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antibiotics, Penicillin; Antimicrobial Resistance; Antimicrobial resistant; Bacteremia; Biotransformation; Blood Circulation; Blood Plasma; Bloodstream; Bone Infection; Care, Health; Caring; Categories; Cellulitis; Circulation; Clinical; Clinical Data; Clinical Pharmacology; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Communities; Data; Development; Discipline of obstetrics; Dose; Drug Kinetics; Drugs; Effectiveness; Embryonic Tissue, Placenta; Endocarditis; Enzymes; Ethnic Origin; Ethnicity; Ethnicity aspects; Exposure to; Fetus; Genes; Genetic; Genetic Polymorphism; Genus staphylococcus; Gestation; Goals; Healthcare; Human, Adult; Incidence; Infection; Intravenous; Lead; Life; MRSA; Maternal Physiology; Measurement; Medication; Metabolic Biotransformation; Methicillin Resistance; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Microorganisms, General; Miscellaneous Antibiotic; Morbidity; Morbidity - disease rate; Mothers; Neonatal; Obstetrics; Osteomyelitis; Outcome; Patients; Pb element; Penicillins; Perinatal; Perinatal Exposure; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pharmacology, Clinical; Phase 2 Clinical Trials; Phase II Clinical Trials; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Plasma; Pneumonia; Pneumonitis; Polymorphism (Genetics); Polymorphism, Genetic; Postpartum; Postpartum Period; Postpartum Women; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Pregnant Women; Principal Investigator; Publishing; Pulmonary Inflammation; Recurrence; Recurrent; Regimen; Research; Resistance; Resistance to antibiotics; Resistance to antimicrobial; Resistance, Antibiotic; Resistant to antibiotics; Resolution; Reticuloendothelial System, Serum, Plasma; Role; S. aureus; S.aureus; Safety; Septic Shock; Serum, Plasma; Site; Skin; Soft Tissue Infections; Staphylococcus; Staphylococcus aureus; Transmission; Treatment Failure; United States; Vancomycin; Vancomycin Resistance; Woman; Women, Postpartum; Work; adult human (21+); anti-microbial; anti-microbial resistance; anti-microbial resistant; antibiotic resistant; antimicrobial; bacteraemia; clinical investigation; drug/agent; fetal; fetal exposure; heavy metal Pb; heavy metal lead; in utero exposure; intra-uterine environmental exposure; intrauterine environmental exposure; mastitis; methicillin resistant; methicillin resistant Staphylococcus aureus (organism); microorganism; neonate; patient population; phase 2 study; phase 2 trial; phase II trial; placental transfer; polymorphism; pregnant; protocol, phase II; resistance to anti-microbial; resistant; resistant strain; resistant to anti-microbial; resistant to antimicrobial; social role; standard of care; study, phase II; telavancin; transmission process; uptake; vancomycin resistant; wound",Obstetric Pharmacology Research Units Network Center at UTMB-Galveston,,47891,ZHD1,Special Emphasis Panel,,6,1007037,
7798387,U10,HD,2,,02/01/2010,12/31/2010,HD-09-002,2U10HD047892-06,,NICHD:1002006;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SEATTLE,UNITED STATES,OTHER HEALTH PROFESSIONS,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"EASTERLING, THOMAS R;HEBERT, MARY F (contact);THUMMEL, KENNETH E.;",6120071 (contact);6227775;6729022;,2U10HD047892,07/01/2004,12/31/2014,"21+ years old; ABCB1; ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; Adult; After Care; After-Treatment; Aftercare; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Applications Grants; Basic Research; Basic Science; Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-; Biochemical; Biological; CP33; CP34; CPD6; CYP2D; CYP2D6; CYP2D6 gene; CYP2DL1; CYP3; CYP3A; CYP3A13; CYP3A3; CYP3A4; CYP3A4 gene; CYPIIIA4; Caring; Clinical; Clinical Data; Clinical Research; Clinical Study; Common Rat Strains; Data; Diabetes Mellitus; Diabetes Mellitus, Gestational; Diabetes, Gestational; Diabetes, Pregnancy-Induced; Dimethylbiguanidine; Dimethylguanylguanidine; Discipline of obstetrics; Dose; Drug Kinetics; Drug Therapy; Drug Transport; Drugs; Embryonic Tissue, Placenta; Enzymes; Evaluation; Fetal Age; Fetal Maturity, Chronologic; Fetus; Funding; Gastrointestinal Tract, Small Intestine; Genotype; Gestation; Gestational Age; Gestational Diabetes; Glibenclamide; Glybenclamide; Glyburide; Glyburide-metformin; Goals; Grant Proposals; Grants, Applications; HLP; Human; Human, Adult; Human, General; Imidodicarbonimidic diamide, N,N-dimethyl-; Intermediary Metabolism; Intestines, Small; Kidney; Kinetic; Kinetics; Liver; MDR1 Protein; METBL; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Medication; Membrane; Messenger RNA; Metabolic Processes; Metabolism; Metformin; Methods; Mice; Micronase; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Murine; Mus; NF-25; Obstetrics; Oral; Organic Cation Transporter; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein Transporter; P-Glycoproteins; P450-DB1; P450-PCN1; P450C2D; P450C3; P450PCN1; PGY-1 Protein; Patients; Perinatal Exposure; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pharmacotherapy; Physiologic; Physiological; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Population; Postpartum; Postpartum Period; Pregnancy; Pregnant Women; Programs (PT); Programs [Publication Type]; RNA, Messenger; Rat; Rattus; Research; Role; Safety; Sampling; Small Intestines; Staging; Testing; Therapeutic; Time; Toxic effect; Toxicities; Translating; Translatings; Universities; Urinary System, Kidney; Washington; Woman; adult human (21+); age dependent; age related; anti-diabetic drugs; antidiabetic; base; biomarker; body system, hepatic; comparative; design; designing; diabetes; diabetes of pregnancy; diabetic; dosage; drug/agent; experience; experiment; experimental research; experimental study; fetal; fetal exposure; glycemic control; improved; in utero exposure; intra-uterine environmental exposure; intrauterine environmental exposure; language translation; mRNA; measurement of metabolism; membrane structure; metabolomics; multidisciplinary; neonate; organ system, hepatic; pregnant; programs; protein expression; renal; research study; response; small bowel; social role; translational study",University of Washington Obstetric-fetal Pharmacology Research Unit,,47892,ZHD1,Special Emphasis Panel,,6,1002006,
7798374,U10,HD,2,,02/01/2010,12/31/2010,HD-09-002,2U10HD047905-06,,NICHD:1027538;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PITTSBURGH,UNITED STATES,,14,119132785,US,PA,152133180,MAGEE-WOMEN'S RES INST AND FOUNDATION,"CARITIS, STEVE N;",1896410;,2U10HD047905,07/01/2004,12/31/2014,"1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid; 17 alpha-hydroxyprogesterone caproate; 17 alpha-hydroxyprogesterone capronate; 17 alpha-oxyprogesterone capronate; 17-((1-oxohexyl)oxy)pregn-4-ene-3,20-dione; 17-alpha-hydroxy-progesterone caproate; 17-hydroxyprogesterone capronate; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-; Absorption; Affect; After Care; After-Treatment; Aftercare; American; Analysis, Data; Area; Cervical; Cervix; Cervix Uteri; Chemotherapy-Hormones/Steroids; Clinical; Corlutina; Corluvite; Corpus Luteum Hormone; Cyclogest; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; DXM; Data; Data Analyses; Delta4-pregnene-3,20-dione; Dextromethorphan; Discipline of obstetrics; Dose; Drug Formulations; Drug Kinetics; Drugs; Endocrine Gland Secretion; Enzymes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Formulation; Formulations, Drug; Genetic Polymorphism; Genital System, Female, Cervix; Genital System, Female, Vagina; Gestagenic Agents; Gestagens; Gestation; Gestiron; Gestone; Gynecology; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; High Risk Woman; Hormones; Hydroxyprogesterone Caproate; Indocin; Indometacin; Indomethacin; Lead; Length; Lipo-Lutin; Liquid substance; Liver Cells; Luteohormone; Lutocyclin; Lutocylin M; Lutogyl; Lutromone; MMPs; Matrix Metalloproteinases; Medication; Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-; Obstetrics; Organ; P450; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Pharmacology; Polymorphism (Genetics); Polymorphism, Genetic; Postpartum; Postpartum Period; Pregn-4-ene-3,20-dione; Pregnancy; Pregnant Women; Pregnenedione; Premature Birth; Preterm Birth; Process of absorption; Progestagenic Agents; Progestasert; Progestational Agents; Progestational Compounds; Progestational Hormones; Progesterone; Progesterone Agents; Progestins; Progestogel; Progestogens; Progestol; Progeston; Prolidon; Proluton; Proteome; Protocol; Protocols documentation; Recruitment Activity; Research; Research Activity; Research Resources; Resources; Risk; Sampling; Structure; Syngesterone; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Therapeutic Progestin; Time; Universities; Uterine Cervix; Utrogestan; Vagina; Vaginal; Woman; absorption; biomarker; college; cytokine; d-Methorphan; density; drug/agent; enzyme activity; experience; fetal; fluid; heavy metal Pb; heavy metal lead; hydroxyprogesterone hexanoate; interest; liquid; meetings; oxyprogesterone caproate; polymorphism; premature childbirth; premature delivery; preterm delivery; protocol development; recruit; response; sharing data; women at high risk","Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response",,47905,ZHD1,Special Emphasis Panel,,6,1027538,
7790006,U42,RR,2,,03/01/2010,02/28/2011,RR-09-003,2U42RR014817-11,,NCRR:1458321;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CHAPEL HILL,UNITED STATES,GENETICS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MAGNUSON, TERRY ;",1900365;,2U42RR014817,09/30/1999,02/28/2015,"Address; Archives; Collection; Communities; Cryofixation; Cryopreservation; Diathesis; Disease susceptibility; ES Cell Line; Embryonic Stem Cell Line; Fertilization in Vitro; Funding; Future; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gnotobiotic; Gnotobiotics; Human; Human, General; IVF; Individual; Infrastructure; Investigators; Mammals, Mice; Man (Taxonomy); Man, Modern; Medicine; Methods; Mice; Mice, Mutant Strains; Mouse Strains; Murine; Mus; Mutant Strains Mice; Mutation; Phenotype; Physiologic; Physiological; Procedures; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Science of Medicine; Services; Sperm; Spermatozoa; Technology; Test-Tube Fertilization; cold preservation; cold storage; disease/disorder proneness/risk; gene function; genome mutation; genome, mouse; human disease; improved; liability to disease; meetings; mouse genome; mouse mutant; mutant; mutant mouse model; new technology; oxidative damage; pathogen; public health relevance; repository; sperm cell; zoosperm",A Carolina Center to Characterize and Maintain Mutant Mice,,14817,ZRR1,Special Emphasis Panel,,11,1458321,
7948033,U62,PS,2,,01/01/2010,12/31/2010,PS1-0-1001,2U62PS023512-06,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,HOUSTON,UNITED STATES,,09,194586517,US,TX,77054,HOUSTON DEPARTMENT/HEALTH/HUMAN SRVS,"MCNEESE-WARD, MARLENE ;",9026586;,2U62PS023512,01/01/2004,12/31/2011,,"PS10-1001, HIV PREVENTION PROJECTS ",,23512,ZPS1,Special Emphasis Panel,,6,5154303,
7991644,X98,SM,2,,10/01/2009,09/30/2011,,2X98SM006097-10,,CMHS:;,2010,Center for Mental Health Services,,PAGO PAGO,UNITED STATES,,,,US,AS,96799,AS OFFICE OF PROTECTION/ADV FOR DISABLED,"TAGOILELAGI, UTA LALOULU ;",10387581;,2X98SM006097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,6097,ZSM1,Special Emphasis Panel,,10,230800,
8014863,B08,TI,3,,10/01/2009,09/30/2011,,3B08TI010005-10S1,,CSAT:;,2010,Center for Substance Abuse Treatment,,SACRAMENTO,UNITED STATES,,05,,US,CA,95814,CALIFORNIA STATE DEPT/ALC AND DRUG PROGS,"ZITO, RENEE ;",10322031;,3B08TI010005,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10005,ZTI1,Special Emphasis Panel,S1,10,71557574,
8013468,B08,TI,3,,10/01/2009,09/30/2011,,3B08TI010006-10S1,,CSAT:;,2010,Center for Substance Abuse Treatment,,DENVER,UNITED STATES,,01,,US,CO,802363120,ALCOHOL AND DRUG ABUSE DIVISION,"WOOD, JANET ;",8098473;,3B08TI010006,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10006,ZTI1,Special Emphasis Panel,S1,10,7817342,
8013470,B08,TI,3,,10/01/2009,09/30/2011,,3B08TI010028-10S1,,CSAT:;,2010,Center for Substance Abuse Treatment,,JEFFERSON CITY,UNITED STATES,,04,878143742,US,MO,65102,MISSOURI STATE DEPT OF MENTAL HEALTH,"STRINGER, MARK ;",10322094;,3B08TI010028,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10028,ZTI1,Special Emphasis Panel,S1,10,7463616,
8014854,B08,TI,3,,10/01/2009,09/30/2011,,3B08TI010039-10S1,,CSAT:;,2010,Center for Substance Abuse Treatment,,CARSON CITY,UNITED STATES,,02,625364849,US,NV,89706,STATE OF NEVADA HEALTH DIVISION,"MCBRIDE, DEBORAH ;",10322127;,3B08TI010039,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10039,ZTI1,Special Emphasis Panel,S1,10,3973002,
8013466,B08,TI,3,,10/01/2009,09/30/2011,,3B08TI010041-10S1,,CSAT:;,2010,Center for Substance Abuse Treatment,,COLUMBUS,UNITED STATES,,12,,US,OH,43215,OHIO STATE DEPT OF ALCHOL/DRUG ADD SRVS,"DAWSON, ANGELA ;",10322133;,3B08TI010041,10/01/2009,09/30/2011,,Substance Abuse Prevention & Treatment Block Grant,,10041,ZTI1,Special Emphasis Panel,S1,10,19020053,
8001130,DP2,DK,3,Y,01/15/2010,03/31/2010,DK-08-001,3DP2DK083099-01S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LUO, XUNRONG ;",8508033;,3DP2DK083099,01/15/2010,03/31/2010,"APC; Allogenic; Antigen-Presenting Cells; Autoantigens; Autoimmune; Autoimmune Diabetes; Autoimmune Process; Autoimmune Status; Autoimmunity; Autologous Antigens; Carbodiimides; Cells; Chemicals; Coupled; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetes, Streptozotocin; Engineering; Engineerings; Goals; Grafting, Islets of Langerhans; Human; Human, General; Humulin R; IDD; IDDM; Immunologic Accessory Cells; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Inbred NOD Mice; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Islets of Langerhans Transplantation; Man (Taxonomy); Man, Modern; Method LOINC Axis 6; Methodology; Mice, Inbred NOD; Modeling; Monocytes / Macrophages / APC; Mouse, NOD; Natural immunosuppression; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; Patients; Protocol; Protocols documentation; Regimen; Route; Self Tolerance; Self-Antigens; Signal Pathway; Splenocyte; Streptozocin Diabete; Streptozocin Diabetes; T1 diabetes; T1D; T1DM; Therapeutic; Toxic effect; Toxicities; Translating; Translatings; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 1 diabetes; abstracting; accessory cell; alloimmunity; clinical relevance; clinically relevant; diabetic; immunosuppression; improved; insulin dependent diabetes; islet allograft; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet transplantation; isoimmunity; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; language translation; novel; self recognition (immune); type I diabetes",ECDI Coupled Cells for Tolerance in Allogeniec Islet Cell Transplantation for T1D,,83099,ZDK1,Special Emphasis Panel,S1,1,100000,
8015385,F31,AR,3,,07/01/2009,06/30/2010,PA-07-106,3F31AR056204-02S1,,NIAMS:23921;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LOMA LINDA,UNITED STATES,OTHER BASIC SCIENCES,41,009656273,US,CA,92350,LOMA LINDA UNIVERSITY,"LINARES, GABRIEL ROBERT;",9180555;,3F31AR056204,07/01/2008,06/30/2011,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; Active Oxygen; Age; Aging; Androst-4-en-17beta-ol-3-one; Antioxidants; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Attenuated; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blotting, Western; Body Tissues; Bone; Bone Density; Bone Formation; Bone Mineral Density; Bone and Bones; Bones and Bone Tissue; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Ca++ element; Calcium; Cardiolipins; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell-Death Protease; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Change of Life, Female; Coagulation Factor IV; Cysteine Protease CPP32; DNA Fragmentation; Data; Death; Defense Mechanisms; Delta4-androsten-17beta-ol-3-one; Deterioration; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Factor IV; Family; Family member; Female; Ferricytochrome c; Ferrocytochrome c; Foundations; Fracture; Fracture due to osteoporosis; Free Radical Scavengers; GHN; Gender; Genes; Genetic; Genome; Goals; Grant; Growth Hormone; Growth Hormone 1; Heavy Drinking; Hormonal; ICE-like protease; Incidence; Injection of therapeutic agent; Injections; Lead; Life Style; Lifestyle; Location; Mammals, Mice; Membrane; Membrane Potentials; Menopause; Mice; Microarray Analysis; Microarray-Based Analysis; Mitochondria; Modeling; Molecular; Murine; Mus; Names; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis with fracture; Osteoporotic fracture; Oxidative Stress; Oxygen Radicals; PARP Cleavage Protease; Pathway interactions; Pb element; Pituitary Growth Hormone; Play; Pro-Oxidants; Public Health; RNA, Small Interfering; Reactive Oxygen Species; Regulation; Resting Potentials; Risk; Role; SCA-1; SREBP Cleavage Activity 1; STH; Senescence; Small Interfering RNA; Smoking; Somatotropin; Subcellular Process; Testing; Testosterone; Therapeutic Testosterone; Tissues; Trans-Testosterone; Transmembrane Potentials; United States; Western Blotting; Western Blottings; Western Immunoblotting; Yama; Yama protein; Yeasts; age dependent; age related; anti-oxidant; base; bone; bone fracture; bone mass; caspase; caspase-3; cell type; combat; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytochrome c; drink heavily; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; fight against; glutaredoxin; hGHN; heavy alcohol use; heavy metal Pb; heavy metal lead; member; membrane structure; menopausal; microarray technology; mitochondrial; mitochondrial membrane; osteoporosis with pathological fracture; oxidation; pathway; protein blotting; psychological defense mechanism; public health medicine (field); sedentary; senescent; siRNA; social role; somatotropic hormone",Regulation of Oxidative Stress Induced Apoptosis in Osteoblasts,,56204,ZRG1,Special Emphasis Panel,S1,2,23921,
8015417,F32,DK,3,,07/01/2009,06/30/2010,,3F32DK080574-01S1,,NIDDK:58886;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"PASSERO, CHRISTOPHER JOHN;",8934997;,3F32DK080574,07/01/2008,06/30/2011,"Absorption; Affect; Aldosterone; Aldosteronism; Amino Acids; Antiproteases; Apical; Apoplexy; Autoregulation; BP control; Balance, Fluid; Blood Pressure; Blood Pressure, High; Bowman's Space; Bowman's space; Cardiac infarction; Cell membrane; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Charge; Chemotherapy-Hormones/Steroids; Cleaved cell; Clinical; Collecting Cell; Cytoplasmic Membrane; Development; Disease; Disorder; Distal; Dropsy; Duct; Duct (organ) structure; ENaC; ENaC (epithelial Na+ channel); Edema; Endocrine Gland Secretion; Endopeptidase Inhibitors; Epithelial; Equilibrium; Essential Hypertension; Esteroproteases; Event; Fibrinolysin; Fluid Balance; Generations; Glu-Plasmin; Homeostasis; Hormones; Human; Human, General; Hydrops; Hyperaldosteronism; Hypertension; Ion Channels, Sodium; Kidney; Kidney Collecting Ducts; Kidney Diseases; Kidney Failure; Kidney Insufficiency; Kidney Tubules, Collecting; Leg; Liquid substance; MMPs; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mentors; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutate; Myocardial Infarct; Myocardial Infarction; Na element; Nephrons; Nephropathy; Nephrotic Syndrome; Oocytes; Ovocytes; PRSS8; PRSS8 protein, human; Patients; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Peptides; Peripheral; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Plasmin; Platanna; Play; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Probability; Process; Process of absorption; Proprostasin; Prostasin; Prostasin Preproprotein; Protease Antagonists; Protease F; Protease Inhibitor; Proteases; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; Regulation; Renal Disease; Renal Failure; Renal Insufficiency; Research; Risk Factors; Role; Serine Endopeptidases; Serine Protease; Serine Protease-8; Serine Protein Hydrolases; Serine Proteinases; Site; Sodium; Sodium Channel; Sodium Chloride; Sodium chloride (NaCl); Stroke; Structure of Bowman's space; Structure of collecting tubule; Swelling; Symptoms; Syndrome; System; System, LOINC Axis 4; TGN; Therapeutic Hormone; Time; Urinary Space; Urinary System, Kidney; Uriniferous Tube; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; Xenopus laevis; Xenopus oocyte; absorption; aminoacid; apical membrane; balance; balance function; blood pressure control; blood pressure homeostasis; blood pressure regulation; brain attack; cardiac infarct; cerebral vascular accident; cleaved; collecting tubule structure; combat; coronary attack; coronary infarct; coronary infarction; disease/disorder; epithelial Na+ channel; experiment; experimental research; experimental study; extracellular; fluid; heart attack; heart infarct; heart infarction; human PRSS8 protein; human disease; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; inhibitor; inhibitor/antagonist; kidney disorder; liquid; mutant; new therapeutic target; plasmalemma; prevent; preventing; primary hypertension; renal; renal disorder; research study; salt; social role; stroke; synthetic peptide; therapeutic target; trans-Golgi Network; urinary",Modulation of the Epithelial Sodium Channel by Proteases and Peptide Inhibitors,,80574,ZRG1,Special Emphasis Panel,S1,1,58886,
8012922,H79,SP,3,,12/30/2009,12/29/2010,SP-09-004,3H79SP015623-02S1,,CSAP:;,2010,Center for Substance Abuse Prevention,,ALEXANDRIA,UNITED STATES,,08,942512948,US,VA,22314,COMMUNITY ANTI-DRUG COALITIONS OF AMER,"KIM, JIN S;",9732356;,3H79SP015623,12/31/2008,12/29/2013,,"Produce the annual National Leadership Forum, Community Prevention Day and Mid-Ye",,15623,ZOA1,Special Emphasis Panel,S1,2,26000,
7993809,K01,DK,3,Y,01/15/2010,12/31/2010,PA-00-019,3K01DK073266-04S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"PAUNESCU, TEODOR G.;",8231176;,3K01DK073266,01/15/2010,12/31/2010,"3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; ATP phosphohydrolase; ATP pyrophosphate-lyase (cyclizing); ATPase; Acid-Base Imbalance; Acidosis, Renal Tubular, Type I; Acids; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine Triphosphatase; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenosinetriphosphatase; Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Animal Model; Animal Models and Related Studies; Back; Basic Research; Basic Science; Bicarbonates; Cell membrane; Cells; Classic Distal Renal Tubular Acidosis; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Membrane; Dark Cell; Defect; Distal Renal Tubular Acidosis; Distal renal tubular acidosis Type 1; Dorsum; Duct; Duct (organ) structure; Enzymes; Epithelial Cells; Fluorescence; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; H(+) Pump; H+ element; HCO3; Hearing Loss, Sensorineural; Holoenzymes; Human; Human, General; Hybrids; Hydrogen Carbonates; Hydrogen Ions; Image; Intercalated Cell; Isoforms; Kidney; Knockout Mice; Laboratories; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane; Membrane Biology; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Murine; Mus; Mutation; Null Mouse; Organelles; PKA; Physiologic; Physiological; Plasma Membrane; Process; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Kinase A; Proteins; Proton Pump; Protons; RNA, Messenger; Recovery; Regulation; Relative; Relative (related person); Renal function; Replacement Therapy; Research; Role; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Techniques; Training Programs; Transgenic Mice; Urinary System, Kidney; V-ATPase; V-type ATPase; adenosine 3'5' monophosphate; adenylcyclase; apical membrane; base; cAMP; cAMP-Dependent Protein Kinases; career; gene product; genome mutation; imaging; in vivo; interdisciplinary approach; kidney function; knockout animal; laser capture microdissection; mRNA; membrane structure; model organism; novel; plasmalemma; programs; protein expression; renal; response; social role; trafficking; treatment strategy; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",Regulation of V-ATPase-mediated Renal Proton Secretion,,73266,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,4,54000,
7993804,K01,DK,3,Y,01/01/2010,12/31/2010,PAR-05-066,3K01DK078513-02S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"KOHLER, JAMES J;",1957605;,3K01DK078513,01/01/2010,12/31/2010,"1-(2'fluoro-2'-deoxyarabinofuranosyl)-5-iodouracil; 1-(2-deoxy-2-fluoro-beta-arabinofuranosyl)-5-iodouracil; 2'-fluoro-5-iodoarauracil; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-PMPA; AIDS; ATP biosynthesis (oxidative); AZT; AZT (Antiviral); Ablation; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adverse effects; Anions; Anti-Retroviral Agents; Antiretroviral Agents; Award; Azidothymidine; Biogenesis; Biological; Blotting, Western; Body Tissues; CCL21; CCL21 gene; CKb9; Cadherins; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cells; Chronic Kidney Failure; Chronic Renal Disease; Clinical; Complex; Cristobalite; DISSEC; DNA, Mitochondrial; Disease; Disorder; Dissection; Doctor of Philosophy; Dose; Drug Combinations; Drug Kinetics; Dysfunction; Electromagnetic, Laser; Electron Transport; Environment; Epithelial; Epithelial Cells; Epithelium; Evaluation; Event; FIAU; Family; Fellowship Program; Functional disorder; Gender; Glomerular disease; Human; Human, General; Immunologic Deficiency Syndrome, Acquired; Infection; Injury; Investigators; K-Awards; K-Series Research Career Programs; Kidney; Kidney Diseases; Kidney Failure; Kidney Failure, Chronic; Kidney Insufficiency; Kidney Tubules; Kidney Tubules, Proximal; Knock-out; Knockout; Knockout Mice; Lasers; Liver Cell Adhesion Molecules; MGC34555; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane Transport Proteins, Organic Anion; Mentors; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microscopic; Mitochondria; Mitochondrial DNA; Molecular; Murine; Mus; Nephropathy; Nucleosides; Nucleotides; Null Mouse; Organic Anion Transporters; Origin of Life; Outcome; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Pathogenesis; Pathology; Ph.D.; PhD; Pharmacokinetics; Phosphates; Phosphorylation; Physiopathology; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Protein Trafficking; Proteins; Proximal Kidney Tubules; Radiation, Laser; Renal Cell; Renal Disease; Renal Failure; Renal Failure, Chronic; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Renal tubule structure; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Reverse Transcriptase Inhibitors; SCYA21; SLC; Sampling; Sand; Schools, Medical; Series; Silica; Silicon Dioxide; Structure; TCA4; Tenofovir; Tenofovir disoproxil fumarate; Thymidine, 3'-azido-3'-deoxy-; Time; Tissues; Toxic effect; Toxicities; Traffickings, Protein; Training; Transgenic Mice; Transgenic Organisms; Treatment Period; Treatment Side Effects; Tridymite; Tubular; Tubular formation; Universities; Urinary System, Kidney; Virus; Viruses, General; Western Blotting; Western Blottings; Western Immunoblotting; Work; ZDV; Zidovudine; anti-retroviral; antiretroviral; antiretroviral therapy; azidodeoxythymidine; base; chronic kidney disease; disease/disorder; electron transfer; experience; experiment; experimental research; experimental study; fialuridine; gain of function; gene product; in vivo; inorganic phosphate; insight; kidney cell; kidney disorder; liver cell adhesion molecule; loss of function; medical schools; member; mitochondrial; mtDNA; nucleotide analog; pathogen; pathophysiology; polypeptide; programs; protein blotting; protein transport; renal; renal disorder; renal proximal tubule; renal tubular transport; renal tubule; replicase; research study; side effect; standard of care; therapy adverse effect; tool; transgenic; treatment adverse effect; treatment days; treatment duration",Mechanisms of Tenofovir Renal Tubular Toxicity,,78513,ZDK1,Special Emphasis Panel,S1,2,54000,
8011267,K01,DK,3,Y,01/20/2010,01/19/2011,PA-06-001,3K01DK081620-02S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"CHEN, SWAINE L;",2090878;,3K01DK081620,01/20/2010,01/19/2011,"Algorithms; Amino Acids; Antibiotic Therapy; Antibiotic Treatment; Bacteria; Binding; Binding (Molecular Function); Bladder; D-Mannose; Disease; Disorder; Epithelium; Evolution, Molecular; Genes; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic defect; Genomics; In Vitro; Infection; Lead; Mammals, Mice; Mannopyranose; Mannopyranoside; Mannose; Methods; Mice; Modeling; Molecular; Molecular Evolution; Molecular Genetic; Molecular Genetics; Molecular Interaction; Murine; Mus; Mutation; Pathogenicity Factors; Pathway interactions; Pb element; Publishing; Recurrence; Recurrent; Research; Role; Screening procedure; Specificity; Staging; Testing; UPEC; UTI; Urinary System, Bladder; Urinary tract; Urinary tract infection; Urinary tract infectious disease; Uropathogenic E coli; Uropathogenic E. coli; Uropathogenic E.coli; Uropathogenic Escherichia coli; Validation; Virulence; Virulence Factors; Woman; aminoacid; disease/disorder; experiment; experimental research; experimental study; extracellular; fitness; genetic determinant; genome mutation; heavy metal Pb; heavy metal lead; in vivo; mouse model; mutant; new therapeutic target; novel; pathogenic bacteria; pathway; public health relevance; research study; screening; screenings; social role; theories; therapeutic target; treatment of bacterial diseases; treatment of bacterial infectious disease; urinary bladder",Molecular study of genes and pathways in late stages of urinary tract infection,,81620,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,2,54000,
8010768,K01,HD,3,Y,02/01/2010,01/31/2011,PA-06-001,3K01HD052018-02S1,,NICHD:50000;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SEATTLE,UNITED STATES,PHYSICAL MEDICINE & REHAB,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"KELLY, VALERIE E;",6166823;,3K01HD052018,02/01/2010,01/31/2011,"Address; Affect; Age; Attention; Award; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cognition; Cognitive; Cost Measures; Development; Disease; Disease Progression; Disorder; Dose; Drugs; Dysfunction; Exhibits; Functional disorder; Gait; Gender; Goals; Idiopathic Parkinson Disease; Impairment; Individual; Instruction; K-Awards; K-Series Research Career Programs; Knowledge; Lead; Lewy Body Parkinson Disease; Life; Measures; Measures, Cost; Medication; Mentors; Mentorship; Motor; Movement; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pb element; Performance; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Health Services / Rehabilitation; Physiopathology; Population; Primary Parkinsonism; Process; Protocol; Protocols documentation; QOL; Quality of life; Rehabilitation; Rehabilitation Research; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Research; Research Career Program; Research Career Programs, K-Series; Research Resources; Resources; Response Latencies; Risk; Role; Scientist; Speed; Speed (motion); Surface; Task Performances; Testing; Therapeutic Intervention; Training; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Walking; Work; base; body movement; career; cost; disease/disorder; drug/agent; environmental change; experience; experiment; experimental research; experimental study; falls; heavy metal Pb; heavy metal lead; improved; insight; intervention therapy; language translation; motor deficit; motor impairment; neural mechanism; neuromechanism; pathophysiology; public health relevance; rehab strategy; rehabilitation strategy; rehabilitative; research study; response; skills; social role; translation research enterprise",Attention and the Automatic Control of Walking in People with Parkinson's Disease,,52018,CHHD,National Institute of Child Health and Human Development Initial Review Group,S1,2,50000,
8010766,K01,HD,3,Y,02/01/2010,01/31/2011,PA-06-001,3K01HD058035-01A1S1,,NICHD:44900;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PITTSBURGH,UNITED STATES,OTHER HEALTH PROFESSIONS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"PIVA, SARA R.;",8969708;,3K01HD058035,02/01/2010,01/31/2011,"Affect; Area; Arthritis; Atrophic Arthritis; Award; Basic Research; Basic Science; Biochemical; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Clinical; Collaborations; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Development; Doctor of Philosophy; EMI scan; Effectiveness; Electric Stimulation; Electrical Stimulation; Environment; Enzymes; Exercise; Exercise, Physical; Fats; Fatty acid glycerol esters; Goals; Health; Image; Individual; Inflammatory Arthritis; Intervention; Intervention Strategies; Investigation; Investigators; Isokinetic Exercise; Isokinetics; Isotonic Exercise; Isotonics; Lower Extremity; Lower Limb; Master of Science; Membrum inferius; Mentors; Metabolic; Mitochondria; Muscle; Muscle Fibers; Muscle Tissue; Muscle function; Muscle rehabilitation; Muscle, Skeletal; Muscle, Voluntary; Musculoskeletal; Myotubes; Participant; Patient Self-Report; Patients; Performance; Ph.D.; PhD; Physiatric Procedure; Physical Function; Physical Health Services / Rehabilitation; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Programs (PT); Programs [Publication Type]; Qualifying; Questionnaires; Randomized; Reading; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Research Personnel; Researchers; Rhabdomyocyte; Rheumatoid Arthritis; Sampling; Self-Report; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Testing; Tomodensitometry; Tomography, Xray Computed; Training; Universities; X-Ray Computed Tomography; arthritic; base; career; catscan; computed axial tomography; computerized axial tomography; computerized tomography; conference; design; designing; enzyme activity; functional outcomes; imaging; implementation research; improved; indexing; interventional strategy; mitochondrial; muscle hypertrophy; muscle strength; neuromuscular; post intervention; professor; programs; randomisation; randomization; randomly assigned; rehabilitation science; rehabilitative; response; skills; symposium",Neuromuscular Electrical Stimulation in Individuals with Rheumatoid Arthritis,,58035,CHHD,National Institute of Child Health and Human Development Initial Review Group,A1S1,1,44900,
7996213,K08,DK,3,Y,01/08/2010,12/31/2010,PA-00-003,3K08DK068226-06S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"CAI, HUI ;",7552314;,3K08DK068226,01/08/2010,12/31/2010,"Address; Affect; Anabolism; Benzothiadiazine Diuretics; Biliary; Blood Pressure, High; Blotting, Northern; Brain; Canal of Wirsung; Canine Species; Canis familiaris; Cell Line; Cell Lines, Strains; Cell membrane; CellLine; Cells; Cercopithecus pygerythrus; Chloride; Chloride Ion; Cl- element; Clinical; Cytoplasmic Membrane; Data; Disease; Disorder; Distal; Dogs; Duct; Duct (organ) structure; Duct of the Epididymis; EC 2.7; Encephalon; Encephalons; Endoplasmic Reticulum, Granular; Ependyma; Ependymal Tissue; Epididymal duct structure; Epithelium; Ergastoplasm; Essential Hypertension; Family member; Genetic Alteration; Genetic Change; Genetic defect; Golgi; Golgi Apparatus; Golgi Complex; Green Monkey; Hyperkalemias; Hyperpotassemia; Hypertension; In Vitro; Ion Transport; Kidney; Kinases; L-Lysine; L-Serine; L-Threonine; Lysine; M cell; MDCK cell; Madin Darby canine kidney cell; Mammalian Cell; Mammals, Dogs; Mammals, Mice; Membrane; Metabolic acidosis; Mice; Monkey, African Green; Murine; Mus; Mutate; Mutation; Na element; Nephrons; Nervous System, Brain; Northern Blotting; Northern Blottings; Occluding Junctions; PKA kinase; Pancreatic duct; Pathogenesis; Permeability; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Plasma Membrane; Play; Process; Protein Phosphorylation; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; Pseudohypoaldosteronism; RER; RNA blot analysis; RNA blotting; Regulation; Renal function; Research Proposals; Role; Rough ER; Rough endoplasmic reticulum; Rough-Surfaced Endoplasmic Reticulum; Serine; Serine Kinase; Serine-Threonine Kinases; Sodium; Sodium Chloride; Sodium chloride (NaCl); Surface; Sweat; Sweating; Syndrome; System; System, LOINC Axis 4; Testing; Thiazide Diuretics; Threonine; Threonine Kinase; Tight Junctions; Transphosphorylases; Tubular; Tubular formation; Type II Pseudohypoaldosteronism; Urinary System, Kidney; Uriniferous Tube; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Xenopus oocyte; Zonula Occludens; biosynthesis; canine; cultured cell line; disease/disorder; domestic dog; gene product; genome mutation; hyperkalemia; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; in vivo; inhibitor; inhibitor/antagonist; kidney function; member; membrane structure; mutant; novel; perspiration; plasmalemma; primary hypertension; protein kinase A kinase; renal; salt; social role; sodium-chloride cotransporter; sodium-chloride transporter; stable cell line; trafficking; uptake",Sodium Chloride Cotransporter Regulation by WNK Kinase,,68226,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,6,54000,
8010011,K08,DK,3,Y,01/20/2010,12/31/2010,,3K08DK074557-04S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"JEDLICKA, PAUL ;",7849096;,3K08DK074557,01/20/2010,12/31/2010,"21+ years old; Absorption; Accounting; Adult; Affect; Animals; Antimorphic mutation; Apes; Binding; Binding (Molecular Function); Biological; Biological Function; Biological Models; Biological Process; Biology; Body Tissues; Cancers; Cell Communication; Cell Communication and Signaling; Cell Growth in Number; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Transformation, Neoplastic; Cell-to-Cell Interaction; Cells; Cellular Expansion; Cellular Growth; Cellular Migration; Cellular Proliferation; Cessation of life; Chemical Agents; Chromosomes; Colon; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Complex; Control Animal; Data; Death; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; Embryo Development; Embryogenesis; Embryonic Development; Enterocolitis; Environment; Epithelial; Epithelial Neoplasms; Epithelium; Epithelium, Intestinal; Exhibits; Family; Functional disorder; Gastrointestinal Tract, Small Intestine; Gene Products, RNA; Generalized Growth; Genetic; Growth; Human; Human, Adult; Human, General; INFLM; Impairment; Infection; Inflammation; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Injury; Intestinal; Intestinal Neoplasia; Intestinal Neoplasms; Intestinal Tumor; Intestines; Intestines Neoplasms; Intestines, Small; Intracellular Communication and Signaling; Investigation; Investigators; Learning; Life; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Model System; Models, Biologic; Molecular Interaction; Morphogenesis; Motility; Motility, Cellular; Murine; Mus; Natural regeneration; Neoplasms; Neoplastic Cell Transformation; Nutrient; Organ; Organ System; Organism; Pathologic; Pathway interactions; Phenotype; Physiologic; Physiological; Physiopathology; Play; Pongidae; Pre-Malignant; Premalignant; Pressure; Pressure- physical agent; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Family; Proteins; Publishing; RNA; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Regeneration; Research Design; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Intestines; Sodium Dextran Sulfate; Source; Staining method; Stainings; Stains; Structure; Structure of intestinal epithelium; Study Type; Surface; System; System, LOINC Axis 4; Tetracycline Control; Tissue Growth; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Transgenes; Transgenic Mice; Tumor Burden; Tumor Load; Tumor of the Intestines; Tumors; Type I Cell; Type I Epithelial Receptor Cell; VP 16; VP 16 (drug); VP16; Villus; Woman; absorption; adenoma; adult human (21+); base; biological signal transduction; body system; bowel; cell growth; cell motility; design; designing; disease/disorder; extracellular; gene product; great ape; in vivo; injury response; intestinal crypt; intestinal epithelium; intestinal villi; intestine growth; living system; malformation; malignancy; member; men; men's; mouse model; neoplasia; neoplasm/cancer; neoplastic; neoplastic growth; neoplastic transformation; ontogeny; overexpression; pathophysiology; pathway; precancerous; pressure; programs; regenerate; response; response to injury; reverse transcriptase PCR; self-renewal; small bowel; social role; study design; trans acting factor (genetic); transcription factor; transgene expression; villin",Ets transcription factors in intestinal biology,,74557,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,4,54000,
7996183,K08,DK,3,Y,01/07/2010,12/31/2010,PA-00-003,3K08DK075940-04S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"LU, HUA A;",7547460;,3K08DK075940,01/07/2010,12/31/2010,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; 3'5'-cyclic ester of AMP; 70-kD Heat-Shock Protein; AVPR2; AVPR2 gene; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Antidiuretic Hormone; Antidiuretic Hormones; Apoptosis; Apoptosis Pathway; Aquaporins; Assay; Basic Research; Basic Science; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Models; Biological Process; Body Tissues; Brachydanio rerio; Cardiac Failure Congestive; Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cell surface; CellLine; Cells; Cellular Adhesion; Cellular Migration; Cellular biology; Chimera Protein; Chimeric Proteins; Cirrhosis; Clathrin; Clathrin Adaptors; Clathrin Assembly Proteins; Clathrin-Associated Adaptors; Clathrin-Associated Proteins; Coleonol; Complex; Congestive Heart Failure; Culturing, in vitro Vertebrate, Primary; Cyclic AMP; Cyclic GMP; Cytoplasm; Cytoplasmic Membrane; Cytoplasmic Vesicles; Cytoskeletal Proteins; DI1; Danio rerio; Data; Defect; Dental Enamel; Dephosphin; Dephosphorylation; Development; Diabetes Insipidus; Dimensions; Duct; Duct (organ) structure; Dynamin; Dysfunction; Enamel; Endocytosis; Epithelial; Epithelial Cells; Event; Exocytosis; Forskolin; Functional disorder; Fusion Protein; General Hospitals; Genetic Alteration; Genetic Change; Genetic defect; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); HSP; HSP 70; HSP70; Heart Decompensation; Heart Failure, Congestive; Heat shock proteins; Heat-Shock Proteins 70; Hospitals, General; Hydrogen Oxide; Hyponatremia; Impairment; In Vitro; Intracellular Communication and Signaling; Intracellular translocation; Investigators; Kidney; Kidney Tubules; Laboratories; Lead; Light; Liquid substance; Maintenance; Maintenances; Massachusetts; Mediating; Membrane; Membrane Biology; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Model System; Models, Biologic; Molecular; Molecular Interaction; Motility; Motility, Cellular; Mutation; Nephrology; Nervous; Osmoregulation; Pathway interactions; Pb element; Phosphorylation; Photoradiation; Physiologic; Physiological; Physiology; Physiopathology; Plasma Membrane; Play; Primary Cell Cultures; Process; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Phosphorylation; Protein Trafficking; Proteins; RNA, Small Interfering; Recruitment Activity; Recycling; Regulation; Renal tubule structure; Research; Research Personnel; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slice; Small Interfering RNA; Sodium, decreased level; Stimulus; Stress Proteins; Structure; Surface; System; System, LOINC Axis 4; Technology; Time; Tissues; Traffickings, Protein; Transfection; Translating; Translatings; Tubular; Tubular formation; Two Hybrid; Urinary System, Kidney; V2R; Vasopressin Receptor; Vasopressins; Water; Water Channel Proteins; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; Zebra Danio; Zebra Fish; Zebrafish; adenosine 3'5' monophosphate; angiogenesis; base; beta-Hypophamine; biological signal transduction; cAMP; cGMP; career; cell biology; cell motility; cultured cell line; enamelin; experiment; experimental research; experimental study; fat metabolism; fluid; gene product; genome mutation; guanosine 3'5' monophosphate; heavy metal Pb; heavy metal lead; hsp70 Family; in vivo; inhibitor; inhibitor/antagonist; injury and repair; interdisciplinary approach; language translation; lipid metabolism; liquid; malformation; membrane structure; migration; mutant; mutant mouse model; neural; novel; pathophysiology; pathway; plasmalemma; programs; protein complex; protein protein interaction; protein transport; recruit; relating to nervous system; renal; renal tubule; research study; residence; response; siRNA; social role; tooth enamel; trafficking; tuftelin; water channel; water transporter; yeast two hybrid system",Characterization of AQP2 interacting proteins and novel functions of AQP2,,75940,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,4,54000,
7995583,K08,DK,3,Y,01/08/2010,01/07/2011,,3K08DK078014-03S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"SAMPOGNA, ROSEMARY V;",1908663;,3K08DK078014,01/08/2010,01/07/2011,"21+ years old; Acute Kidney Failure; Acute Kidney Tubular Necrosis; Acute Renal Failure with Tubular Necrosis; Address; Adult; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animal Model; Animal Models and Related Studies; Anodynes; Antibodies; Antinociceptive Agents; Antinociceptive Drugs; Area; Award; Behavior; Biochemistry; Biological; Biopsy; Blood Precursor Cell; Body Tissues; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Signaling; Cells; Cellular biology; Cellular injury; Chemistry, Biological; Clinical; Common Rat Strains; Cues; Data; Detection; Diagnostic; Disease; Disorder; Doctor of Philosophy; ESRD; Embryo; Embryonic; End stage renal failure; End-Stage Kidney Disease; Environment; Epithelial; Equilibrium; Evolution; Fellowship; Gene Transcription; Genetic Transcription; Goals; Hb SS disease; HbSS disease; Hematopoietic stem cells; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Human; Human, Adult; Human, General; Hypoxia; Hypoxic; Injury; Internal Medicine; Intracellular Communication and Signaling; Investigation; Investigators; Ischemia-Reperfusion Injury; Kidney; Kidney Diseases; Kidney Failure, Acute; Kidney Insufficiency, Acute; Kidney Papilla; Kidney Part; Kidney Tubular Necrosis, Acute; Label; Laboratories; Lead; Life; Lower Nephron Nephrosis; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medical; Mentored Clinical Scientist Development Award (K08); Mentored Clinical Scientists Development Award; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Microscopy; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Murine; Mus; Nephrology; Nephropathy; Nervous; Organ; Organ System; Oxygen Deficiency; Papilla of tongue; Papillary; Pb element; Ph.D.; PhD; Phased Career Development; Phenotype; Physiologic pulse; Population; Prevalence; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Proliferating; Property; Property, LOINC Axis 2; Public Health; Pulse; RNA Expression; Rat; Rattus; Regulation; Renal Cell; Renal Disease; Renal Disease, End-Stage; Renal Failure, Acute; Renal Insufficiency, Acute; Renal Papilla; Renal function; Reperfusion Damage; Reperfusion Injury; Research Personnel; Researchers; Residencies; Role; Rosemary; Scientist; Sickle Cell Anemia; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Sorting - Cell Movement; Source; Stem cells; Stimulus; Structure; Techniques; Time; Tissues; Training; Transcript; Transcription; Transcription, Genetic; Ureteral obstruction; Urinary System, Kidney; acute tubular necrosis; adult human (21+); adult stem cell; analgesia; balance; balance function; base; biological signal transduction; body system; cell behavior; cell biology; cell damage; cell injury; disease/disorder; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; human tissue; improved; in vivo; insight; interest; kidney cell; kidney development; kidney disorder; kidney function; model organism; multipotent cell; nephrogenesis; neural; overexpression; papilla; programs; public health medicine (field); regenerate new tissue; regenerating damaged tissue; regenerative; relating to nervous system; renal; renal disorder; repair; repaired; research study; response; restoration; sickle cell disease; sickle disease; sicklemia; skills; social role; sorting; therapeutic development; tissue culture; tissue regeneration; tongue papilla; tool; transcription factor; ureter obstruction",Identification and functional analysis of renal stem cells,,78014,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,3,54000,
8011150,K08,DK,3,Y,01/15/2010,12/31/2010,PA-06-512,3K08DK080630-03S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"KAZ, ANDREW M;",7893001;,3K08DK080630,01/15/2010,12/31/2010,"3'-5'-CpG; 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide; Aberrant DNA Methylation; Abscission; Adenocarcinoma Cell; Adenocarcinoma of the Esophagus; Affect; Anti-Oncogenes; Antioncogenes; Assay; Barrett Epithelium; Barrett Esophagus; Barrett Syndrome; Barrett Ulcer; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biometrics; Biometry; Biometry and Biostatistics; Biopsy; Biostatistics; Body Tissues; CDR; CG-dinucleotide; Cancer Screening for Patients; Cancer of the Esophagus; Cancers; Candidate Disease Gene; Candidate Gene; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromosome Mapping; Clinical Trials Design; Collection; Columnar Epithelial-Lined Lower Esophagus; Columnar-Lined Esophagus; CpG Islands; CpG dinucleotide; CpG-Rich Islands; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Crossmatching, Tissue; Cytidine, 2'-deoxy-; Cytosine Deoxyribonucleoside; Cytosine Deoxyriboside; DNA; DNA Methylation; Deoxycytidine; Deoxyribonucleic Acid; Development Plans; Diagnosis; Disease Frequency Surveys; Dysplasia; Early Diagnosis; Emerogenes; Enrollment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelium, Barrett; Esophageal; Esophageal Adenocarcinoma; Esophageal Cancer; Esophageal Tissue; Esophagus; Esophagus Cancer; Event; Excision; Extirpation; Gastrointestinal Tract, Esophagus; Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetics, Gene Mapping; Goals; HDAC Agent; Histocompatibility Testing; Histone Deacetylase Inhibitor; Human; Human, General; Hypermethylation; Individual; Investigators; Lead; Linkage Mapping; Malignant Esophageal Neoplasm; Malignant Esophageal Tumor; Malignant Glandular Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Esophagus; Malignant neoplasm of esophagus; Man (Taxonomy); Man, Modern; Mentorship; Methods; Methylation; Molecular; Molecular Marker of Prognosis; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pattern; Pb element; Physicians; Plans, Development; Process; Prognosis Marker; Prognostic Marker; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Public Health; Removal; Research Design; Research Personnel; Research Specimen; Researchers; Resolution; Risk; Role; Scientist; Screening for cancer; Screening procedure; Specimen; Study Type; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survey Instrument; Surveys; Survival Rate; TSA antibioitc; Technology; Testing; Tissue Crossmatchings; Tissue Typing; Tissues; Translational Research; Translational Research Enterprise; Translational Science; Trichostatin A; Tumor Suppressing Genes; Tumor Suppressor Genes; base; biomarker; cDNA Expression; cancer initiation; cancer risk; career; career development; cultured cell line; cytidine monophosphate guanosine; cytidylyl-3'-5'-guanosine; cytosine-guanine dinucleotide; design; designing; dyscrasia; early cancer detection; early detection; enroll; gene discovery; genetic mapping; genome-wide; heavy metal Pb; heavy metal lead; histocompatibility typing; improved; insight; malignancy; molecular marker; neoplasm/cancer; novel; oncosuppressor gene; programs; public health medicine (field); resection; screening; screenings; social role; statistics/biometry; study design; surgery; translation research enterprise; tricostatin A",Methylated DNA Biomarkers for Barrett's Esophagus and Esophageal Adenocarcinoma,,80630,NCI,Subcommittee E - Prevention & Control,S1,3,54000,
7993844,K08,DK,3,Y,01/15/2010,12/31/2010,PA-06-512,3K08DK080947-02S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"SCHLONDORFF, JOHANNES S;",1896268;,3K08DK080947,01/15/2010,12/31/2010,"Address; Animal Model; Animal Models and Related Studies; Animals; Area; Basement membrane; Binding; Binding (Molecular Function); Biology; Blood Coagulation Factor IV; Ca++ element; Calcineurin; Calcium; Cardiomyopathy, Hypertrophic Obstructive; Cations; Cell Attachment; Cell Communication and Signaling; Cell Signaling; Cell-Matrix Adhesions; Cell-Matrix Junction; Cell/Tissue, Immunohistochemistry; Cells; Cellular biology; Coagulation Factor IV; Cortical Portion of the Kidney; Cytoskeletal Proteins; Data; Development; Dialysis; Dialysis procedure; Disease; Disorder; Dysfunction; ESRD; End stage renal failure; End-Stage Kidney Disease; Endothelial Cells; Experimental Designs; FSGS; Factor IV; Family; Fellowship; Focal Segmental Glomerulosclerosis; Focal segmental glomerular sclerosis; Functional disorder; Gene Expression; Gene Transcription; Generations; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Glomerular disease; Goals; Grafting, Kidney; HTRPY; Heart Hypertrophy; Hereditary; Human; Human, General; Hypertrophic Cardiomyopathy; Hypertrophy; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inherited; Intracellular Communication and Signaling; Investigators; Ion Channel; Ionic Channels; Isoforms; Kidney; Kidney Cortex; Kidney Diseases; Kidney Transplantation; Kidney Transplants; Laboratories; Lead; Lesion; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Channels; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Modeling; Molecular Interaction; Monitor; Murine; Mus; Mutation; NFAT Pathway; NFAT and Hypertrophy of the heart (Transcription in the broken heart); NPHS1 gene product; NPHS2 protein; Nephropathy; PP2B; Pathologic; Pathology; Pathway interactions; Pb element; Physiopathology; Postdoc; Postdoctoral Fellow; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Phosphatase-2B; Proteins; Proteinuria; RNA Expression; Regulation; Relative; Relative (related person); Renal Disease; Renal Disease, End-Stage; Renal Glomerular Diseases and Syndromes; Renal Transplantation; Renal Transplants; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Research; Research Associate; Research Personnel; Researchers; Role; Schools, Medical; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure of cortex of kidney; System; System, LOINC Axis 4; Techniques; Technology; Therapeutic Intervention; Training; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transgenic Animals; Transgenic Mice; Up-Regulation; Urinary System, Kidney; Urinary System, Urine; Urine; Visceral Epithelial Cell; Work; base; biological signal transduction; cardiac hypertrophy; cell biology; cell type; diabetic; dialysis therapy; disease/disorder; effective therapy; experience; gain of function; gene product; genome mutation; glomerular function; glomerular visceral epithelial cell; heavy metal Pb; heavy metal lead; hypertrophic myocardiopathy; imaging; in vivo; insight; intervention therapy; kidney cortex; kidney disorder; medical schools; member; membrane structure; model organism; mutant; nephrin; novel; overexpression; pathophysiology; pathway; patient population; podocin; podocyte; post-doc; post-doctoral; pressure; programs; public health relevance; renal; renal cortex; renal disorder; screening; screenings; slit diaphragm; social role; transcription factor",TRPC6 Regulation and its Role in Glomerular Pathology,,80947,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,2,54000,
7994909,K08,DK,3,Y,01/16/2010,12/31/2010,PA-06-512,3K08DK081403-02S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"GARG, PUNEET ;",7987260;,3K08DK081403,01/16/2010,12/31/2010,"0-11 years old; 21+ years old; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Actin Filaments; Actins; Address; Adult; Affect; Aldrich Syndrome; Amplaxin; Angiitis; Biochemical; Biological; Biology; Blood capillaries; Bowman's Capsule; Bright Disease; CTTN; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Culture Techniques; Cell Function; Cell Junctions; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Child; Child Youth; Children (0-21); Cicatrix; Communicating Junction; Complex; Congenital Nephrotic Syndrome; Cttn protein; Cytoskeletal System; Cytoskeleton; Data; Development; Diabetic Kidney Disease; Diabetic Nephropathy; Dialysis; Dialysis procedure; Disease; Disorder; EMS1; EMS1 Protein; EMS1 protein, human; ESRD; End stage renal failure; End-Stage Kidney Disease; Endothelium; Engineering; Engineerings; Event; Foot Process; Gap Junctions; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glomerular capsule structure; Glomerular disease; Glomerulonephritis; HIV; HTLV-III; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Heymann Nephritis; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Human, General; Injury; Intercellular Junctions; Intracellular Communication and Signaling; Investigators; Kidney; Kidney Diseases; Kidney Failure; Kidney Glomerulus; Kidney Insufficiency; LAV-HTLV-III; Lead; Low-resistance Junction; Lymphadenopathy-Associated Virus; Malpighian Capsule; Malpighian Tuft; Mammals, Mice; Mammary Tumor and Squamous Cell Carcinoma-Associated Protein; Man (Taxonomy); Man, Modern; Mediating; Medicare; Methods and Techniques; Methods, Other; Mice; Microfilaments; Modeling; Molecular; Morbidity; Morbidity - disease rate; Morphology; Mortality; Mortality Vital Statistics; Murine; Mus; Mutate; Mutation; Myofilaments; NPHS1 gene product; NPHS2 protein; Nephropathy; Nephrotic Syndrome; Nervous; Nexus; Nexus Junction; Octopus; Outcome; Patients; Pb element; Pedicel; Physiologic; Physiological; Play; Process; Programs (PT); Programs [Publication Type]; Proteins; Proteinuria; Public Health; Publishing; Regulation; Renal Disease; Renal Disease, End-Stage; Renal Failure; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Research Personnel; Researchers; Role; SRC Substrate Cortactin; SRC8; Scars; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; Techniques; Title 18; Urinary System, Kidney; Vasculitis; Virus-HIV; Visceral Epithelial Cell; Wiskott syndrome; Wiskott-Aldrich Syndrome; Work; adult human (21+); alpha Actinin; base; biological signal transduction; capillary; children; cofilin; cortactin; dialysis therapy; disease/disorder; eczema thromocytopenia diarrhea syndrome; eczema thromocytopenia immunodeficiency syndrome; eczema thromocytopenia syndrome; experiment; experimental research; experimental study; gene product; genome mutation; glomerular basement membrane; glomerular sclerosis; glomerular visceral epithelial cell; glomerulosclerosis; health insurance for disabled; heavy metal Pb; heavy metal lead; human EMS1 protein; injury response; insight; intracellular skeleton; kidney disorder; mouse model; nephrin; neural; p80/85 SRC Substrate; podocin; podocyte; polymerization; positional cloning; programs; protein complex; public health medicine (field); relating to nervous system; renal; renal disorder; renal glomerulus; research study; response to injury; reverse genetics; slit diaphragm; social role; synergism; youngster",Regulation of Podocyte Actin Cytoskeleton,,81403,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,2,54000,
8006669,K08,DK,3,Y,01/25/2010,12/31/2010,PA-06-512,3K08DK081479-02S1,,NIDDK:50000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"KHURANA, SANDEEP ;",9188521;,3K08DK081479,01/25/2010,12/31/2010,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ablation; Acetylcholine; Acetylcholine Agonists; Acids, Bile; Advisory Committees; Agonist; Animals; Aorta; Attenuated; Bacterial Translocation; Bile Acids; Bleeding; Blood Circulation; Blood Plasma Volume; Blood Pressure; Blood Pressure, Low; Blood Serum; Blood Vessels; Bloodstream; Cell Communication and Signaling; Cell Signaling; Cholinergic Agonists; Chronotropism, Cardiac; Chronotropisms, Cardiac; Circulation; Cirrhosis; Clinical; Common Rat Strains; Data; Development; Dysfunction; EC 1.14.13.39; EDRF Synthase; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Environment; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Experimental Animal Model; Experimental Models; Experimental Models, Other; Faculty; Functional disorder; GTP; Gastroenterology; Gene Inactivation; Gene Silencing; Generations; Goals; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanylyl Cyclase-Activating Factor Synthase; Heart Rate; Hemorrhage; Hepatic Disorder; Hepatology; Hydrogen Oxide; Hypertension, Portal; Hypotension; In Vitro; Intracellular Communication and Signaling; Investigation; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-NAME; Liver diseases; M3 receptor; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Maryland; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medicine; Mentors; Mesenteric; Mesenteric Arteries; Mesentery; Mice; Microcirculation; Microdissection; Microscopy, Video; Models, Experimental; Molecular; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinic M3 Receptor; Muscle Relaxation; Muscle relaxation phase; Muscle, Involuntary; Muscle, Smooth; N omega-Nitro-L-arginine Methyl Ester; N(G)-Nitro-L-arginine Methyl Ester; N(G)-Nitroarginine Methyl Ester; NADPH-Diaphorase; NG-Nitro-L-Arginine Methyl Ester; NG-Nitroarginine Methyl Ester; NO Synthase; Na element; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Oxides; Patients; Pharmacological Treatment; Physicians; Physiology; Physiopathology; Plasma Volume; Portal Hypertension; Principal Investigator; Rat; Rattus; Receptor Inhibition; Receptor, Muscarinic M3; Receptors, Muscarinic; Relaxation; Resistance; Rodent; Rodentia; Rodentias; Role; Schools, Medical; Science of Medicine; Scientist; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Slide; Smooth muscle (tissue); Sodium; Stress; Task Forces; Telemetries; Telemetry; Testing; Training; Universities; Vascular Endothelial Cell; Vascular Hypotensive Disorder; Vasodilatation; Vasodilation; Vasorelaxation; Video Microscopy; Videomicrography; Videomicroscopy; Water; Wild Type Mouse; biological signal transduction; blood loss; career; career development; cholinergic; effective therapy; endothelial cell derived relaxing factor; hemodynamics; hepatopathy; in vivo; inhibitor; inhibitor/antagonist; liver disorder; medical schools; member; mouse model; novel; pathophysiology; professor; receptor-mediated signaling; resistant; social role; therapeutic target; vascular",Mechanisms of Vascular Dysfunction in Cirrhosis,,81479,ZDK1,Special Emphasis Panel,S1,2,50000,
8010765,K08,HD,3,Y,02/01/2010,01/31/2011,PA-06-512,3K08HD057555-03S1,,NICHD:44850;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LOS ANGELES,UNITED STATES,SURGERY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LIPSHUTZ, GERALD S;",8418439;,3K08HD057555,02/01/2010,01/31/2011,"AAV vector; ATGN; Advisory Committees; Antibodies; Antigens; Antihemophilic Factor; Assay; B-Cell Development; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor VIII; Blood-coagulation factor VIII, complex; Breeding; Capsid; Capsid Proteins; Cells; Clinical; Coagulation Factor VIII; Coagulation Factor VIIIc; Coat Proteins; Code; Coding System; Communities; Computer Systems Development; Data; Development; Development Plans; Development, Computer Systems; Disease; Disorder; Drug or chemical Tissue Distribution; Educational process of instructing; Embryo; Embryonic; Environment; Epithelial; Epithelium; Event; Exposure to; Factor VIII; Factor VIII Deficiency; Factor VIII F8B; Fetus; Figs; Figs - dietary; Foundations; Future; Gene Delivery; Gene Expression; Gene Therapy Vectors; Gene Transduction Agent; Gene Transduction Vectors; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generations; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Diseases, Inborn; Genetic Intervention; Goals; Hemophilia; Hemophilia A; Hemophilia As; Hereditary; Hereditary Disease; Immune; Immune Tolerance; Immune response; Immune system; Immunity; Immunologic Techniques; Immunologic Tolerance; Immunologic, Immunochemical; Immunologic, Luciferase; Immunological Technics; Immunological Techniques; Immunologics; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Inborn Genetic Diseases; Inherited; Inherited disorder; Injection of therapeutic agent; Injections; Intervention, Genetic; Investigators; Knowledge; Laboratories; Life; Luciferases; Lymphocyte; Lymphocytic; Maintenance; Maintenances; Mammals, Mice; Mediating; Medical center; Mentors; Method LOINC Axis 6; Methodology; Mice; Modeling; Molecular Biology, Gene Therapy; Molecular Disease; Mouse Strains; Murine; Mus; Natural immunosuppression; Nature; Ovalbumin; Phenotype; Plans, Development; Position; Positioning Attribute; Procoagulant Component; Programs (PT); Programs [Publication Type]; Proteins; Reagent; Recombinants; Regulatory T-Lymphocyte; Reporter; Research; Research Personnel; Research Proposals; Researchers; Reticuloendothelial System, Thymus; Scientist; Serotyping; Solid; Survival Rate; Systems Development; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; Task Forces; Teaching; Technics, Immunologic; Testing; Therapeutic; Therapeutic Studies; Therapy Research; Therapy, DNA; Thromboplastinogen; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissue Distribution; Training; Transgenes; Translating; Translatings; Transplantation; Tropism; Viral; Viral Coat Proteins; Viral Outer Coat Protein; Viral Vector; Virus; Viruses, General; Work; adeno-associated viral vector; adeno-associated virus vector; adult animal; anergy; antihemophilic factor A; base; body system, allergic/immunologic; career; career development; clinical relevance; clinically relevant; coat (nonenveloped virus); design; designing; disease/disorder; experience; experiment; experimental research; experimental study; fetal; gene product; gene therapy; genetic disorder; genetic therapy; hereditary disorder; host response; human disease; immune system tolerance; immune unresponsiveness; immunogen; immunological paralysis; immunoresponse; immunosuppression; in utero; in vivo; inborn error; inhibitor; inhibitor/antagonist; interest; language translation; lymph cell; mature animal; mouse model; organ system, allergic/immunologic; platelet cofactor I; postnatal; programs; research study; response; role model; secretory protein; skills; thromboplastinogen A; thymus derived lymphocyte; transfer of a gene; transgene expression; transplant; vector",The Immune Response to Viral Vector and Transgenes in the Fetus,,57555,AITC,"Allergy, Immunology, and Transplantation Research Committee",S1,3,44850,
7985157,K23,DK,3,Y,01/18/2010,01/17/2011,PA-00-004,3K23DK071262-05S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,UROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"PAVLOVICH, CHRISTIAN P;",8031001;,3K23DK071262,01/18/2010,01/17/2011,"2-methylacyl-CoA racemase; Accounting; Active Follow-up; Age-Years; Aging; American; Analysis, Data; Benign; Benign Prostatic Hypertrophy; Biometrics; Biometry; Biometry and Biostatistics; Biopsy; Biostatistics; Blood Serum; Body Fluids; Cancer Detection; Cancer of Prostate; Cancers; Characteristics; Clinic; Clinical; CpG Islands; CpG-Rich Islands; DFN7; DNA Methylation; DNA Molecular Biology; DRE; Data; Data Analyses; Detection; Diagnosis; Differential Display; Digital Rectal Examination; Disease; Disorder; Displays, mRNA Differential; EC 2.5.1.18; EC 3.4.21.34; Environment; FAEES3; Fatty Acid Ethyl Ester Synthase III Gene; Fletcher Factor; Future; GST; GST3; GST3 Gene; GSTP1; GSTP1 gene; GSTPP; General Population; General Public; Generalized Growth; Genital System, Male, Prostate; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione S-Transferase Pi Gene; Glutathione Transferase; Goals; Growth; Heme Transfer Protein; Human Prostate; Human Prostate Gland; Incidence; Institution; Isoforms; KLK3; Kallikrein 3; Learning; Ligandins; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; MeAc CoA racemase; Method LOINC Axis 6; Methodology; Methylation; Modality; Molecular; Molecular Biology; Neoplasms; P-30 Antigen; Patient Representative; Patients; Performance; Plasma Kallikrein Precursor; Plasma Prekallikrein; Population; Predictive Value; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate CA; Prostate Cancer; Prostate Cancer Prevention Trial; Prostate Disease; Prostate Gland; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostatic; Prostatic Cancer; Prostatic Diseases; Prostatic Gland; Prostatic Hyperplasia, Benign; Prostatic Hypertrophy, Benign; Protein Isoforms; Protein Methylation; Proteins; RNA, Noncoding; RNA, Nontranslated; RNA, Untranslated; RX[{..}]glutathione R-transferase; Research; Research Design; Risk; Role; S-Hydroxyalkyl Glutathione Lyase; Screening for Prostate Cancer; Screening procedure; Semenogelase; Seminin; Senescence; Sensitivity and Specificity; Serum; Specificity; Study Type; Testing; Tissue Growth; Training; Tumors; United States; Untranslated RNA; Urinalysis; Urinary System, Urine; Urine; Urologic Surgeon; Urologist; Urology; alpha-methylacyl-CoA racemase; base; benign prostate hyperplasia; biomarker; cancer risk; career; cohort; digital; disease/disorder; follow-up; gamma-Seminoprotein; gene product; glutathione aralkyltransferase; glutathione aryltransferase; hK3 Kallikrein; high risk; improved; kininogenin; mRNA Differential Displays; malignancy; meetings; men; men's; molecular marker; neoplasia; neoplasm/cancer; neoplastic growth; novel; ontogeny; prostate cancer early detection; prostate disorder; rectal; screening; screenings; senescent; social role; statistics/biometry; study design; urinary; urologic; urological",Prostate Cancer Detection by Molecular Urinalysis,,71262,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,5,54000,
7995836,K23,DK,3,Y,01/01/2010,12/31/2010,PA-05-143,3K23DK077568-03S1,,NIDDK:53968;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"WYATT, CHRISTINA M;",8649998;,3K23DK077568,01/01/2010,12/31/2010,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Affect; Americas; Black race; Cardiac; Chronic Disease; Chronic Illness; Chronic Kidney Failure; Chronic Renal Disease; Clinical; Cohort Studies; Communicable Diseases; Complication; Concurrent Studies; Development; Diagnosis; Early Diagnosis; Epidemiology; Epidemiology, Family Medical History; Family Medical History; Family history of; Foundations; Future; Guidelines; HCV; HCV infection; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatic; Hepatic Disorder; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; High Prevalence; Host Factor; Host Factor Protein; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Incidence; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Integration Host Factors; Investigators; Kidney Diseases; Kidney Failure; Kidney Failure, Chronic; Kidney Insufficiency; LAV-HTLV-III; Liver; Liver diseases; Lymphadenopathy-Associated Virus; Minority; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NANBH; Negroes; Nephropathy; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Patients; Population; Prevalence; Programs (PT); Programs [Publication Type]; Publishing; Renal Disease; Renal Failure; Renal Failure, Chronic; Renal Insufficiency; Research Personnel; Researchers; Risk; Risk Factors; Screening procedure; Societies; T-Lymphotropic Virus Type III Infections, Human; Testing; Translational Research; Translational Research Enterprise; Translational Science; Viral; Viral Diseases; Virus; Virus Diseases; Virus-HIV; Viruses, General; antiretroviral therapy; base; body system, hepatic; chronic disease/disorder; chronic disorder; chronic kidney disease; cohort; early detection; hepatitis non A non B; hepatitis nonA nonB; hepatopathy; high risk; kidney disorder; kidney epithelial cell; liver disorder; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; organ system, hepatic; patient population; programs; prospective; renal disorder; screening; screenings; translation research enterprise; viral infection; virus infection",Kidney Disease in HIV-Hepatitis C Virus Co-Infection,,77568,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,3,53968,
7995832,K23,DK,3,Y,01/01/2010,12/31/2010,PA-05-143,3K23DK078774-03S1,,NIDDK:54000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"MELAMED, MICHAL L;",7886100;,3K23DK078774,01/01/2010,12/31/2010,"4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Affect; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Albumins; Albuminuria; Alcohol Drinking; Alcohol consumption; Autoregulation; Behavioral; Black Populations; Black or African American; Blood Coagulation Factor IV; Blood Pressure; Blood Serum; Bone; Bone and Bones; Bones and Bone Tissue; CREA; Ca++ element; Calcium; Cancers; Cardiac Failure Congestive; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cessation of life; Chronic Kidney Failure; Chronic Renal Disease; Clinical; Clinical Investigator; Coagulation Factor IV; Communities; Congestive Heart Failure; Controlled Clinical Trials; Creatinine; Data; Data Sources; Death; Dialysis; Dialysis procedure; Diet; Diet Supplement; Dietary Supplements; Disease; Disease Outcome; Disease Progression; Disorder; Dose; ESRD; Eating; Elderly; Elderly, over 65; End stage renal failure; End-Stage Kidney Disease; Endocrine; Epidemic; EtOH drinking; Excretory function; Factor IV; Female Health; Food Intake; Freezing; Funding; Future; General Population; General Public; Goals; Grant; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Heart Decompensation; Heart Failure, Congestive; Hemodialyses; Hemodialysis; Hispanic Populations; Hispanics; Hispanics or Latinos; Homeostasis; Hyperparathyroidism, Secondary; Incidence; Individual; Intake; Investigators; K-Awards; K-Series Research Career Programs; Kidney Diseases; Kidney Failure, Chronic; Knowledge; Laboratories; Latino Population; Life; Malignant Neoplasms; Malignant Tumor; Masks; Master's Degree; Measures; Medical center; Medicare; Medicare claim; Mentors; Minority; Mortality; Mortality Vital Statistics; NCHS; NHANES; NRSA; National Center for Health Statistics; National Center for Health Statistics (U.S.); National Health and Nutrition Examination Survey; National Research Service Awards; Nephrology; Nephropathy; Nutritional Supplement; Organ System, Cardiovascular; Participant; Patient Care; Patient Care Delivery; Patients; Physiological Homeostasis; Placebo Control; Population; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Race; Racial Group; Randomized; Randomized Clinical Trials; Recommendation; Renal Disease; Renal Disease, End-Stage; Renal Failure, Chronic; Renin-Angiotensin System; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Proposals; Research Specimen; Researchers; Risk; Risk Factors; Safety; Sampling; Secondary Hyperparathyroidism; Secondary Hyperparathyroidisms; Serum; Smoking; Sources, Data; Spanish Origin; Specimen; Staging; Stocks, Racial; Sun Exposure; Supplementation; Survey Instrument; Surveys; Testing; Therapeutic Steroid Hormone; Title 18; Trials, Randomized Clinical; United States; United States National Center for Health Statistics; Urinary System, Urine; Urine; VIT D; Vascular, Heart; Vitamin D; Vitamin D Deficiency; Woman; Women's Health; advanced age; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; black American; bone; cardiovascular disorder; cardiovascular risk; cardiovascular risk factor; career; chronic kidney disease; circulatory system; clinical epidemiology; design; designing; dialysis therapy; disease/disorder; dosage; elders; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; excretion; geriatric; group intervention; health insurance for disabled; high risk; hispanic community; improved; indexing; kidney disorder; late life; later life; malignancy; neoplasm/cancer; novel; older adult; older person; open label; patient oriented research; patient oriented study; post-menopausal; postmenopausal; programs; race differences; racial difference; randomisation; randomization; randomly assigned; renal disorder; secondary outcome; senior citizen; solar exposure; steroid hormone",Racial Disparities in Chronic Kidney Disease and Vitamin D: Are they related?,,78774,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,3,54000,
7993797,K23,DK,3,Y,01/08/2010,12/31/2010,,3K23DK079056-03S1,,NIDDK:50288;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"BRUNELLI, STEVEN ;",8507020;,3K23DK079056,01/08/2010,12/31/2010,"Address; Animal Model; Animal Models and Related Studies; Area; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autonomic Dysfunction; Biochemical; Blood Pressure; Blood Serum; Blood Vessels; Calendar; Cardiac Failure Congestive; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Chronic; Clinical; Clinical Investigator; Congestive Heart Failure; Data; Development; Development Plans; Dialysis; Dialysis patients; Dialysis procedure; Disease; Disorder; Drugs; ESRD; End stage renal failure; End-Stage Kidney Disease; Ethics; Event; Goals; HOSP; Heart Decompensation; Heart Failure, Congestive; Hemodialyses; Hemodialysis; Hospitalization; Individual; Intervention; Intervention Strategies; Investigators; Knowledge; Liquid substance; Maintenance; Maintenances; Measures; Medication; Membrane; Mentors; Methods; Metric; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nature; Organ System, Cardiovascular; Osmolalities; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Philadelphia; Plans, Development; Population; Prevalence; Prospective Studies; R01 Mechanism; R01 Program; RPG; Randomized; Regimen; Renal Disease, End-Stage; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk; Risk Factors; SCHED; Sampling; Schedule; Seasonal Cycle; Seasonal Variations; Serum; Time; Ultrafiltration; United States; Uremia; Uremias; Variant; Variation; Variations, Seasonal; Vascular, Heart; Waxes; Work; atheromatosis; atherosclerotic vascular disease; cardiovascular disorder; cardiovascular risk; cardiovascular risk factor; career development; circulatory system; cohort; design; designing; dialysis therapy; disease/disorder; drug/agent; experience; fluid; interest; interventional strategy; liquid; membrane structure; metropolitan; model organism; novel; prospective; public health relevance; randomisation; randomization; randomly assigned; time interval; trend; uremia of renal origin; vascular",Blood pressure variability and cardiovascular disease in hemodialysis patients,,79056,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,3,50288,
7994914,K23,DK,3,Y,01/01/2010,12/31/2010,PA-05-143,3K23DK080139-02S1,,NIDDK:53796;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"NICKOLAS, THOMAS L.;",8452460;,3K23DK080139,01/01/2010,12/31/2010,"21+ years old; 3-D; 3-Dimensional; Academic Medical Centers; Adult; Age; Area; Arts; Au element; Award; BMI percentile; BMI z-score; Biomechanics; Biometrics; Biometry; Biometry and Biostatistics; Biopsy; Biopsy Sample; Biopsy Specimen; Biostatistics; Body mass index; Bone; Bone Density; Bone Diseases; Bone Diseases, Metabolic; Bone Mineral Density; Bone and Bones; Bone remodeling; Bone structure of tibia; Bones and Bone Tissue; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cellular biology; Characteristics; Chemotherapy-Hormones/Steroids; Chronic Kidney Failure; Chronic Renal Disease; Clinical Investigator; Cognitive Discrimination; Competence; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Coxa; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; DXA; Data Set; Dataset; Deterioration; Development Plans; Diagnostic tests; Dialysis; Dialysis patients; Dialysis procedure; Discrimination; Discrimination (Psychology); Disease Frequency Surveys; Dual-Energy X-Ray Absorptiometry; Dysfunction; EMI scan; ESRD; End stage renal failure; End-Stage Kidney Disease; Endocrine Gland Secretion; Endocrinology; Epidemiologic Methods; Epidemiological Methods; Epidemiological Techniques; Epidemiology, Methods; Evolution; Finite Element Analyses; Finite Element Analysis; Fracture; Functional disorder; Gender; General Population; General Public; Goals; Gold; Hand; Hip; Hip Fractures; Hip region structure; Hormones; Human, Adult; Image; Incidence; Individual; Investigators; Kidney; Kidney Failure, Chronic; Knowledge; Markers, Serum; Measurement; Measures; Mechanics; Medical; Mentors; Metabolic Bone Diseases; Metabolic disorder of bone; Metabolism and Endocrinology; Methods and Techniques; Methods, Other; Minerals; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nephrology; Osteoporosis; Patients; Peripheral; Physiopathology; Plans, Development; Predisposition; Prevalence; Public Health; Quetelet index; Race; Racial Group; Radial; Receiver Operating Characteristics; Renal Disease, End-Stage; Renal Failure, Chronic; Renal Osteodystrophy; Renal function; Reporting; Research Personnel; Researchers; Resolution; Risk; Scanning; Sensitivity and Specificity; Serum Markers; Severities; Severity of illness; Site; Spinal Column; Spine; Staging; Stocks, Racial; Structure; Susceptibility; Techniques; Technology; Testing; Therapeutic Hormone; Thick; Thickness; Tibia; Tomodensitometry; Tomography, Xray Computed; Training; University Medical Centers; Urinary System, Kidney; Vertebral column; X-Ray Absorptiometry, Dual-Energy; X-Ray Computed Tomography; adult human (21+); backbone; biomarker; bone; bone cell; bone disorder; bone fracture; bone mass; bone metabolism disorder; bone quality; bone remodelling; bone strength; bone turnover; career development; catscan; cell biology; chronic kidney disease; computed axial tomography; computerized axial tomography; computerized tomography; dialysis therapy; disease severity; high risk; imaging; imaging modality; improved; indexing; kidney function; meetings; metabolic bone disease; new technology; novel marker; pathophysiology; public health medicine (field); public health relevance; renal; skills; statistics/biometry; substantia spongiosa; substantia trabecularis; tibia; tool; trabecular bone; ultra high resolution",Bone Quality and Mechanical Competence In Chronic Kidney Disease,,80139,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,2,53796,
8011151,K24,DK,3,Y,01/15/2010,12/31/2010,PA-04-107,3K24DK069290-05S1,,NIDDK:34938;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CHALASANI, NAGA P.;",3126690;,3K24DK069290,01/15/2010,12/31/2010,"0-11 years old; 2(3H)-Benzoxazolone, 5-chloro-; 21+ years old; Address; Adult; Age; Alcohol Drinking; Alcohol consumption; Alkane 1-Hydroxylase; Alkane 1-monooxygenase; Alkane Hydroxylase; Animal Model; Animal Models and Related Studies; Antabuse; Anthropometry; Area; Award; Bis(diethylthiocarbamoyl) Disulfide; Blood Plasma; Blood Serum; CPE1; CYP2E; CYP2E1; CYP2E1 gene; CYP4A; CYP4A11; CYP4A11 protein, human; CYPE1; CYPIVA11; Child; Child Youth; Childhood; Children (0-21); Chlorzoxazone; Chronic; Cirrhosis; Clinical; Clinical Investigator; Clinical Pharmacology; Clinical Research; Clinical Study; Cytochrome P-450; Cytochrome P-450 4A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P-450 IVA; Cytochrome P450; Dicarboxylic Acids; Diet; Dietary intake; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disorder; Disulfiram; Drugs; EXTMR; Enrollment; Enzymes; EtOH drinking; Extramural; Extramural Activities; Faculty; Fatty Acid Omega-Hydroxylase; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Fibrosis; Free Fatty Acids; Funding; Gender; Goals; Grant; Hepatic; Hepatic Disorder; Hepatology; Hepatotoxic effect; Hepatotoxicity; Histologic; Histologically; Human; Human, Adult; Human, Child; Human, General; INFLM; Imidodicarbonimidic diamide, N,N-dimethyl-; Indiana; Individual; Inflammation; Injury; Inpatients; Insulin Resistance; Investigators; Ketones; L-Methionine; Laurate Omega-Hydroxylase; Lauric Acid (Omega-1)-Hydroxylase; Lauric Acid Hydroxylase; Lauric Acid Monooxygenase; Lauric Acid Omega-hydroxylase; Learning; Lipid Peroxidation; Lipids; Liver; Liver Steatosis; Liver Toxicity; Liver diseases; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Medication; Mentors; Mentorship; Messenger RNA; Metformin; Methionine; Methionine, L-Isomer; Mice; Minor; Murine; Mus; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Nonesterified Fatty Acids; Obesity; Omega-1 Hydroxylase; Omega-Hydroxylase; Omega-Lauryl Hydroxylase; Oxidative Stress; P-450 HK omega; P450; P450-HL-omega; P450-J; P450C2E; Pathogenesis; Pathway interactions; Patients; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology, Clinical; Plasma; Play; Population; Process; Production; Productivity; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Publications; RNA, Messenger; Relative; Relative (related person); Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Serum, Plasma; Role; Scientific Publication; Serum; Serum, Plasma; Shunt; Shunt Device; Source; Testing; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Tetraethylthiuram Disulfide; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-; Time; Toxic effect on liver cells; Training of Investigators; United States; United States National Institutes of Health; Universities; adiposity; adult human (21+); alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; body system, hepatic; children; corpulence; corpulency; corpulentia; cytochrome P-450 CYP4A11 (human); cytochrome P450 4A11; cytokine; disease/disorder; drug/agent; enroll; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experiment; experimental research; experimental study; fatty acid omega-hydroxylase CYP4A11; gene product; hepatic steatosis; hepatopathy; hepatoxicity; human CYP4A11 protein; in vivo; inhibitor; inhibitor/antagonist; insulin resistant; insulin sensitizer; insulin sensitizing drugs; interest; investigator training; lauric acid omega-hydroxylase CYP4A11; liver disorder; mRNA; model organism; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; organ system, hepatic; oxidation; pathway; patient oriented research; patient oriented study; pediatric; programs; research study; shunts; social role; stem; translational study; urinary; youngster",Patient-Oriented Research of Liver Disease,,69290,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,5,34938,
8011153,K24,DK,3,Y,01/15/2010,12/31/2010,PA-00-005,3K24DK070528-05S1,,NIDDK:47000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"SHERMAN, KENNETH E;",1977225;,3K24DK070528,01/15/2010,12/31/2010,"Address; Alcoholic; Alcohols; Antiretroviral Therapy, Highly Active; Boozer; Causality; Chemical Class, Alcohol; Dependent drinker; Diagnosis; Drug Industry; Drug toxicity; Elements; Etiology; Faculty; Funding; Goals; Grafting, Liver; HAART; HCV; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; Hepatic Disorder; Hepatitis C virus; Hepatitus C; Highly Active Antiretroviral Therapy; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Individual; Industry, Pharmaceutic; Liver Transplant; Liver diseases; Mentorship; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural immunosuppression; Pathogenesis; Patients; Pharmaceutical Industry; Programs (PT); Programs [Publication Type]; Research; Research Activity; Role; Source; Special Population; Students; T-Lymphotropic Virus Type III Infections, Human; Training; Transplant Recipients; Transplantation of liver; Transplantation, Hepatic; Treatment outcome; United States; United States National Institutes of Health; Viral hepatitis; anti-retroviral therapy, highly active; base; career; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; hepatopathy; immunosuppression; liver disorder; liver transplantation; named group; patient oriented research; patient oriented study; problem drinker; programs; research study; social role; tool; transplant patient",Mentorship in Liver Disease,,70528,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S1,5,47000,
7996827,M01,RR,3,,01/20/2010,11/30/2010,,3M01RR020359-05S2,,NCRR:1339580;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,WASHINGTON,UNITED STATES,,00,143983562,US,DC,20010,CHILDREN'S RESEARCH INSTITUTE,"BATSHAW, MARK L;",1867090;,3M01RR020359,02/01/2005,11/30/2010,,General Clinical Research Center,,20359,RIRG,National Center for Research Resources Initial Review Group,S2,5,1339580,
8013264,P01,DK,3,Y,02/01/2010,01/31/2011,,3P01DK033506-25S1,,NIDDK:89478;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"WALKER, W ALLAN;",1867742;,3P01DK033506,02/01/2010,01/31/2011,,Barrier Function of the GI Tract in Health and Disease,,33506,ZDK1,Special Emphasis Panel,S1,25,89478,
8009979,P01,TP,3,,09/30/2009,09/29/2010,TP-08-001,3P01TP000304-02S1,,ODCDC:;,2010,COORDINATING OFFICE FOR TERRORISM PREPAREDNESS AND EMERGENCY RESPONSE,,PITTSBURGH,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"POTTER, MARGARET A;",9487345;,3P01TP000304,09/30/2008,09/29/2013,,UNIVERSITY OF PITTSBURGH PREPAREDNESS AND EMERGENCY RESPONSE RESEARCH CENTER,,304,ZTP1,Special Emphasis Panel,S1,2,336720,
8011652,P20,MD,3,,01/21/2010,08/31/2010,MD-02-002,3P20MD000272-05S3,,NCMHD:297115;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,ATLANTA,UNITED STATES,NONE,05,102005451,US,GA,30310,MOREHOUSE SCHOOL OF MEDICINE,"SATCHER, DAVID ;",2407416;,3P20MD000272,09/30/2002,08/31/2010,,THREE DIMENSIONAL APPROACH TO ELIMINATING DISPARITIES I*,,272,ZMD1,Special Emphasis Panel,S3,5,297115,
8011157,P30,DK,3,Y,02/01/2010,01/31/2011,DK-04-020,3P30DK040561-14S2,,NIDDK:300329;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"WALKER, W ALLAN;",1867742;,3P30DK040561,02/01/2010,01/31/2011,,Harvard Clinical Nutrition Research Center,,40561,ZDK1,Special Emphasis Panel,S2,14,300329,
8009923,P41,EB,3,,01/12/2010,01/31/2010,,3P41EB002025-25S1,,NIBIB:51405;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CHAPEL HILL,UNITED STATES,PHYSICS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"SUPERFINE, RICHARD ;",6117949;,3P41EB002025,05/01/1984,01/31/2010,,Computer Integrated Systems for Microscopy&Manipulation,,2025,ZRG1,Special Emphasis Panel,S1,25,51405,
8013172,P50,HD,3,,01/01/2010,12/31/2010,HD-04-027,3P50HD052120-04S1,,NICHD:66663;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,TALLAHASSEE,UNITED STATES,PSYCHOLOGY,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"WAGNER, RICHARD K;",1968017;,3P50HD052120,07/01/2006,12/31/2011,,Predicting and Preventing the Development of Learning D*,,52120,ZHD1,Special Emphasis Panel,S1,4,66663,
8010749,P60,MD,3,,01/14/2010,04/30/2010,MD-06-002,3P60MD000502-07S1,,NCMHD:100000;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"FOUAD, MONA N.;",1887884;,3P60MD000502,09/30/2003,04/30/2012,,Comprehensive Minority and Health Disparities Research Center,,502,ZMD1,Special Emphasis Panel,S1,7,100000,
8009950,R00,GM,3,Y,01/08/2010,12/31/2010,PA-07-297,3R00GM081399-03S1,,NIGMS:170150;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,BIOLOGY,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"GILBERT, WENDY VICTORIA;",8785350;,3R00GM081399,01/08/2010,12/31/2010,"5'-Adenylic acid, homopolymer; Architecture; Assay; Binding Proteins; Bio-Informatics; Bioassay; Biochemical; Biochemical Genetics; Biochemistry; Bioinformatics; Biologic Assays; Biological; Biological Assay; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemistry, Biological; Collaborations; Complex; D-Glucose; DISSEC; Data; Defect; Dextrose; Dissection; Education; Educational aspects; Elements; Engineering / Architecture; Environment; Future; Gene Expression; Generalized Growth; Genes; Genetic, Biochemical; Glucose; Growth; IRES; In Vitro; In element; Indium; Initiation Factors; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; Investigators; Lead; Ligand Binding Protein; Link; Location; Mediating; Messenger RNA; Microarray Analysis; Microarray-Based Analysis; Molecular; Molecular Genetic; Molecular Genetics; Osmotic Shocks; Oxidative Stress; Pathway interactions; Pb element; Peptide Initiation Factors; Physiologic; Physiological; Poly A; Poly(rA); Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Proteins; RNA Sequences; RNA, Messenger; RNA-Binding Proteins; RNA-Protein Interaction; Recombinants; Recruitment Activity; Regulation; Research; Research Personnel; Researchers; Ribosome Entry Site; Ribosomes; Role; S cerevisiae; Saccharomyces cerevisiae; Saccharose; Sequences, RNA; Shocks, Osmotic; Signal Pathway; Starvation; Stress; Students; Subcellular Process; Sucrose; Tissue Growth; Training; Translating; Translatings; Translation Initiation; Translation Initiation Factor; Translational Initiation Factor; Translational Regulation; Translations; Viral; Withdrawal; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; comparative; experiment; experimental research; experimental study; fascinate; gene product; heavy metal Pb; heavy metal lead; human disease; in vivo; insight; interest; language translation; mRNA; microarray technology; mutant; ontogeny; pathway; polyadenylate; recruit; research study; response; skills; social role",Mechanisms and Regulation of Yeast Internal Ribosome Entry Sites,,81399,NSS,,S1,3,170150,
8009595,R00,GM,3,Y,01/20/2010,12/31/2010,PA-07-297,3R00GM085212-02S1,,NIGMS:45500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"MORRISON, ASHBY J.;",8023168;,3R00GM085212,01/20/2010,12/31/2010,"Achievement; Achievement Attainment; Address; Affect; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Preservation; Cancers; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Chromosome Segregation; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA lesion; Data; Defect; Deoxyribonucleic Acid; Development; Disease; Disease Progression; Disorder; Environment; Foundations; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genome; Genome Instability; Genome Stability; Genomic Instability; Genomics; Goals; Histones; In Vitro; InAs; L-Lysine; Lysine; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Maps; Mitotic; Mutation; Nucleosomes; Outcome; Pathway interactions; Preservation, Biologic; Preservation, Biological; Process; Programs (PT); Programs [Publication Type]; Proteomics; Publishing; Regulation; Research; Role; S cerevisiae; Saccharomyces cerevisiae; Site; Stability, Genomic; Subcellular Process; Testing; Unscheduled DNA Synthesis; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; YeastModel; base; chromatin remodeling; disease/disorder; genome mutation; genome-wide; histone modification; in vitro activity; in vivo; indium arsenide; insight; malignancy; neoplasm/cancer; pathway; preservation; prevent; preventing; programs; repair; repaired; response; social role",Chromatin-modifying functions of INO80 in the preservation of genomic integrity,"Cancer development evolves through a multi-step process that provides cells with a proliferative and/or survival advantage through the attainment of multiple genetic alterations, which are often caused by disruptions in pathways that maintain genomic integrity. These studies will provide insight into the mechanisms within the natural cellular environment that prevent the accumulation of genomic perturbation.",85212,NSS,,S1,2,45500,
8005632,R01,CA,3,,01/01/2010,12/31/2010,,3R01CA118365-04S1,,NCI:58672;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"MEYERAND, M ELIZABETH;",6150579;,3R01CA118365,03/01/2007,12/31/2010,"AGTR2; AGTR2 gene; AT2; Area; Astrocytoma, Grade IV; Blood Volume; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Cancer Radiotherapy; Cancer of Brain; Carbogen Breathing; Cellularity; Cerebrum; Chemical Shift Imaging; Clinical; Data; Diffusion; Dropsy; Edema; Encephalon; Encephalons; Functional Imaging; Glioblastoma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Hydrops; Hypoxia; Hypoxic; Imaging Procedures; Imaging Techniques; Individual; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Cell; Malignant Tumor of the Brain; Malignant neoplasm of brain; Maps; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods and Techniques; Methods, Other; Microscopic; NIH RFA; NMR Imaging; NMR Tomography; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; O element; O2 element; Organism-Level Process; Organismal Process; Oxygen; Oxygen Deficiency; Patients; Perfusion; Perfusion Magnetic Resonance Imaging; Perfusion Weighted MRI; Permeability; Physiologic; Physiologic Imaging; Physiologic Processes; Physiological; Physiological Processes; Physiology; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Radiation; Radiation therapy; Radiotherapeutics; Radiotherapy; Recurrence; Recurrent; Relative; Relative (related person); Request for Applications; Research; Scanning; Technics, Imaging; Techniques; Time; Tumor Volume; Volume, Tumor; Weight; Wood; Wood material; Zeugmatography; base; blood oxygen level dependent; cancer cell; glioblastoma multiforme; high risk; imaging modality; interest; irradiation; programs; ray (radiation); spongioblastoma multiforme; treatment planning; tumor; tumors in the brain",Treatment Planning using Physiologic MRI Data,,118365,MEDI,Medical Imaging Study Section,S1,4,58672,
8008627,R01,CA,3,,01/01/2010,12/31/2010,,3R01CA120278-04S1,,NCI:46170;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,PATHOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"FULTON, AMY ;",1865244;,3R01CA120278,02/01/2007,12/31/2011,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; Active Follow-up; Apoptosis; Apoptosis Pathway; Arachidonic Acid Cyclooxygenase; Arm; Behavior; Binding; Binding (Molecular Function); Breast; Breast Adenocarcinoma; Breast Cancer Treatment; Breast Neoplasms; Breast Tumors; COX; COX inhibitor; COX-2 protein; COX2; COX2 enzyme; COX2 inhibitor; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Chronic; Class I Antigens; Class I Major Histocompatibility Antigens; Clinical; Colon; Complex; Complex Class 1; Coxibs; Cyclo-Oxygenase; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytolysis; Cytotoxic cell; Development; Dinoprostone; Disease; Disorder; EP4; ESP 13.2 protein, human; ESP-H4 protein, human; Effector Cell; Endocrine Gland Secretion; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epididymal Secretory Protein E4; Epididymis-Specific Whey-Acidic Type Four-Disulfide Core Protein; Epithelial; Equilibrium; Fatty Acid Cyclo-Oxygenase; Forecast of outcome; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Genes, Class I; Genes, MHC Class I; Genetic; Goals; HE4 protein, human; Histocompatibility Antigens Class I; Hormonal; Hormones; Human; Human, General; Hydroperoxide Cyclase; Immune; Immune Function, Cellular; Immune response; In Vitro; Inhibitors, Cyclo-Oxygenase; Intracellular Communication and Signaling; K lymphocyte; Lesion; Ligands; Localized Disease; Lung; Lysis; MHC Class I; MHC Class I Genes; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; Major Epididymis-Specific Protein E4; Major Histocompatibility Complex Class 1; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary adenocarcinoma; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Molecular Interaction; Murine; Mus; NK Cells; Natural Killer Cells; Neoplasm Metastasis; Outcome; PGE Receptors; PGE2; PGE2 Receptors; PGE2 alpha; PGE2alpha; PGH Synthase; PGH Synthase 2; PGH2 Synthetase; PGHS-2; PGHS2; PHS II; PTGS2; Pathway interactions; Population; Prognosis; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin E Receptor; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin Endoperoxide Synthase Inhibitors; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H Synthase; Prostaglandin H2 Synthase 2; Prostaglandin H2 Synthetase; Prostaglandin Synthase; Prostaglandin Synthase Inhibitors; Prostaglandin Synthesis Antagonists; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 2; Putative Protease Inhibitor WAP5; Receptor Protein; Respiratory System, Lung; Risk; Role; Secondary Neoplasm; Secondary Tumor; Series; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Stream; Subcellular Process; T-Cells; T-Lymphocyte; T-Lymphocyte and NK-Cell; T-Lymphocyte and Natural Killer Cell; Testing; Therapeutic; Therapeutic Hormone; Thymus-Dependent Lymphocytes; Tumor Angiogenesis; Tumor Cell; Tumor Cell Migration; Upper arm; WAP Domain Containing Protein HE4-V4; WAP Four-Disulfide Core Domain Protein 2; WAP four-disulfide core domain 2 protein, human; WFDC2; WFDC2 protein, human; Woman; advanced disease; balance; balance function; base; biological signal transduction; cancer metastasis; cultured cell line; cyclo-oxygenase II; cyclooxygenase 2; disease/disorder; epididymal secretory protein E4, human; epididymis-specific protein E4, human; epididymis-specific protein HE4, human; follow-up; host response; human WFDC2 protein; immune function; immunogenic; immunoresponse; improved; intervention development; malignancy; malignant breast neoplasm; mammary; mammary tumor; neoplasm/cancer; neoplastic cell; new approaches; novel; novel approaches; novel strategies; novel strategy; outcome forecast; overexpression; pathway; patient population; pre-clinical; preclinical; prevent; preventing; prostaglandin H synthase-2; protein expression; pulmonary; receptor; response; selective expression; selectively expressed; social role; therapy development; thymus derived lymphocyte; treatment development; tumor; tumor growth; tumorigenic",Cyclooxygenase Modulators of Immune Function in Breast Cancer,,120278,CII,Cancer Immunopathology and Immunotherapy Study Section,S1,4,46170,
8012899,R01,CA,3,,02/01/2010,01/31/2011,PA-07-173,3R01CA132637-03S1,,NCI:48411;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,PEDIATRICS,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"GAO, SHOU-JIANG ;",7678925;,3R01CA132637,04/01/2008,01/31/2012,"AIDS; ANGPT2; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Activator Protein-1; Ang-2; Ang2; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibition; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Angiogenesis Modulators; Angiogenesis Pathway; Angiogenetic Antagonists; Angiogenic Antagonists; Angiogenic Factor; Angiogenic Inhibition; Angiopoietin-2; Angiostatic Agents; Animal Model; Animal Models and Related Studies; Animals; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Assay; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bioassay; Biologic Assays; Biological Assay; Blood Vessel Tumor; Body Tissues; CLG; Cancer Treatment; Cancers; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; Cellular Proliferation; Complex; Development; Differentiation Factor, B-Cell; Disease; Disorder; Drugs; EC 2.7.2-; Endothelial Cells; Enhancer-Binding Protein AP1; Extracellular Signal-Regulated Kinases; Factor, Angiogenesis; Fibroblast Collagenase; Gene Expression; Generalized Growth; Genes; Genes, Viral; Genome; Goals; Growth; HHV-8; HHV8; HPGF; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IHC; IL-6; IL6 Protein; INFLM; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; In element; Indium; Individual; Infection; Infiltration; Inflammation; Inflammatory; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Interstitial Collagenase; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Knock-out; Knockout; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MEKs; MGI-2; MMP-1; MMP-1Fibroblast Collagenase; MMP1; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Matrix Metalloproteinase-1; Mediating; Medication; Mitogen-Activated Protein Kinases; Modeling; Molecular; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Hemorrhagic Sarcoma; Myeloid Differentiation-Inducing Protein; Neoplasms in Vascular Tissue; Neovascularization Inhibitors; ORFs; Oncogenesis; Open Reading Frames; Oral; Pathogenesis; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmacytoma Growth Factor; Play; Prevention; Preventive; Process; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Coding Region; Recombinants; Regulation; Repression; Research; Role; Societies; Spindle Endothelial Cell; Staging; System; System, LOINC Axis 4; Testing; Therapeutic; Time; Tissue Growth; Tissues; Transcription Factor AP-1; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tumor Angiogenesis; Umbilical vein; VEGF, Hypoxia, and Angiogenesis; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Genome; Viral Proteins; Virus Diseases; Virus-HHV8; Work; angiogenesis; antiangiogenic; anticancer therapy; base; blood vessel neoplasm; cancer therapy; cellular targeting; disease/disorder; drug/agent; expectation; human herpesvirus 8; imaging; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; interdisciplinary approach; interferon beta 2; malignancy; model organism; mutant; neoplasm/cancer; novel; ontogeny; paracrine; pathway; programs; reconstitute; reconstitution; social role; therapeutic target; tumor; tumor growth; tumorigenesis; viral infection; virus infection; virus protein",Mechanism of KSHV-induced angiogenesis,,132637,ZRG1,Special Emphasis Panel,S1,3,48411,
8009975,R01,CA,3,,01/01/2010,12/31/2010,PA-07-070,3R01CA133774-03S1,,NCI:52429;,2010,NATIONAL CANCER INSTITUTE,,OMAHA,UNITED STATES,BIOCHEMISTRY,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"BATRA, SURINDER KUMAR;",7243646;,3R01CA133774,03/01/2008,12/31/2012,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; ATRA; Adhesions; Adhesives; Age; Alabama; All-trans retinoic acid; American; American Cancer Society; Animals; Aspiration, Respiratory; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood; Blood Serum; Breathing; British; California; Caloric Intake; Cancer Cause; Cancer Cell Growth; Cancer Etiology; Cancer Induction; Cancer Patient; Cancer cell line; Cancer of Lung; Cancerous; Cancers; Cardiac Diseases; Cardiac Disorders; Causality; Cell Communication and Signaling; Cell Cycle Progression; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell model; Cell surface; CellLine; Cells; Cellular Migration; Cellular Proliferation; Cellular model; Cessation of life; Chronic; Cicatrix; Cigarette; Collaborations; Common Rat Strains; Cotinine; Cytoplasm; DNA Alteration; DNA mutation; DPC4; Data; Death; Development; Diagnosis; Diet; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Duct Dysplasia of the Pancreas; Ductal; Ductal Dysplasia of the Pancreas; ERBB2; ERBB2 gene; Emphysema; Energy Intake; Epidemiology; Etiology; Event; Exhibits; Fats; Fatty acid glycerol esters; Fibroblasts; Fibrosis; Forecast of outcome; Gastrointestinal Tract, Pancreas; Gene Alteration; Gene Expression; Gene Mutation; Generalized Growth; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic defect; Genetic mutation; Glycoproteins; Goals; Growth; HER -2; HER-2; HER2; HER2/neu; Heart Diseases; Hereditary; Histologic; Histologically; Human; Human EGF Receptor 2 Gene; Human, General; IFN; INFLM; In Vitro; Incidence; Inflammation; Inflammatory; Inhalation; Inhaling; Inherited; Inherited Predisposition; Inherited Susceptibility; Inspiration, Respiratory; Interferons; Intracellular Communication and Signaling; Invasive Lesion; Investigation; Investigators; Journals; Knock-out; Knockout; Laboratories; Lesion; Life Style; Lifestyle; MAD Homolog 4 Gene; MADH4; MADH4 gene; MUC 4 protein; MUC4 mucin; Magazine; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Membrane; Metabolic; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Model System; Modeling; Models, Biologic; Molecular; Mortality; Mortality Vital Statistics; Mothers Against Decapentaplegic Homolog 4; Motility; Motility, Cellular; Mucins; Mucus Glycoprotein; Murine; Mus; Mutation; Nature; Neoplasm Metastasis; Nicotine; Oncogenic; Organ System; Outcome; P53; PanIN; Pancreas; Pancreas Adenocarcinoma; Pancreas Cancer; Pancreas Neoplasms; Pancreatic; Pancreatic Adenocarcinoma; Pancreatic Cancer; Pancreatic Duct Dysplasia; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic Tumor; Patients; Phenotype; Pre-Malignant; Premalignant; Process; Prognosis; Property; Property, LOINC Axis 2; Publications; Publishing; Pulmonary Cancer; Pulmonary Emphysema; Pulmonary malignant Neoplasm; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reporting; Research; Research Personnel; Research Proposals; Researchers; Reticuloendothelial System, Blood; Retinoic Acid; Risk; Risk Factors; Role; SMAD4; SMAD4/DPC4 Gene; San Francisco; Scars; Scientific Publication; Scotine; Secondary Neoplasm; Secondary Tumor; Sequence Alteration; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smoke; Smoking; Smoking and Health; Smoking and Health Research; Structure; Surgeon; Survival Rate; TKR1; TP53; TP53 gene; TRP53; Testing; Time; Tissue Growth; Tobacco Consumption; Tobacco use; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Tumor Cell; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor of the Pancreas; United States; Universities; Vitamin A Acid; abstracting; all-trans-Retinoic Acid; all-trans-Vitamin A acid; anticancer research; apomucin; biological signal transduction; body system; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; caloric dietary content; cancer cell; cancer metastasis; cancer progression; cancer research; carcinogenesis; cell motility; cell transformation; chronic pancreatitis; cigarette smoke; cigarette smoke-induced; cigarette smoking; cultured cell line; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gain of function; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome mutation; heart disorder; in vivo; inspiration; intraepithelial; lung cancer; malignancy; malignant phenotype; membrane structure; migration; mouse model; neoplasm progression; neoplasm/cancer; neoplastic; neoplastic cell; neoplastic progression; ontogeny; outcome forecast; overexpression; pancreatic neoplasm; pancreatic tumorigenesis; precancerous; premature; recurrent pancreatitis; sialomucin complex; smoke cigarette; smoke inhalation; smoke of cigarettes; social role; trans-Retinoic Acid; transformed cells; tumor progression; tumorigenic; uptake",Smoking and pancreatic cancer,,133774,CE,Cancer Etiology Study Section,S1,3,52429,
8017939,R01,CA,3,,09/21/2009,08/31/2010,PA-07-070,3R01CA136725-01A1S1,,NCI:1983520;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"VAUGHAN, THOMAS L (contact);WHITEMAN, DAVID C;",1945215 (contact);2073604;,3R01CA136725,09/21/2009,08/31/2012,"Adenocarcinoma of the Esophagus; Apoptosis; Apoptosis Pathway; Barrett Esophagus; Barrett Syndrome; Barrett Ulcer; Biological; Blood Sample; Blood specimen; Cancer Cause; Cancer Etiology; Cancers; Candidate Disease Gene; Candidate Gene; Causality; Cell Death, Programmed; Chronic; Clinical Trial Overviews; Columnar Epithelial-Lined Lower Esophagus; Columnar-Lined Esophagus; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Data; Data Pooling; Data Poolings; Deoxyribonucleic Acid; Development; Disease; Disorder; Environmental Factor; Environmental Risk Factor; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epithelium; Esophageal; Esophageal Adenocarcinoma; Esophageal Reflux; Etiology; Family; Female; Funding; GERD; GWAS; Gastro-oesophageal Reflux; Gastroesophageal Reflux; Gastroesophageal reflux disease; Gender; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genome; Genomics; Genotype; Goals; Gonadal Steroid Hormones; Human; Human, General; INFLM; Incidence; Individual; Inflammation; Inflammatory; Inherited Predisposition; Inherited Susceptibility; Insulin Resistance; Interview; Investigators; Knowledge; Light; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Meta-Analyses; Meta-Analysis; Metabolic; Methods; Mitogenesis; Modeling; Neoplastic Processes; Obesity; Over weight; Overweight; Oxidative Stress; Participant; Pathogenesis; Pathway interactions; Pattern; Persons; Phase; Photoradiation; Play; Population Control; Positive Control of Cell Proliferation; Precancerous Conditions; Predisposition; Premalignant Condition; Premalignant State; Prevalence; Prevention; Process; Reflux; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Factors; Role; Sampling; Screening procedure; Severities; Sex Hormones; Sex Steroid Hormones; Source; Stimulation of Cell Proliferation; Susceptibility; Symptoms; Syndrome; Technology; Telomere Maintenance; Telomere Shortening; Twin Multiple Birth; Twins; Unscheduled DNA Synthesis; Variant; Variation; Variation (Genetics); abdominal pressure; adiposity; allelic variant; cancer risk; cigarette smoking; cofactor; corpulence; corpulency; corpulentia; cost; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environmental risk; genetic etiology; genetic mechanism of disease; genetic risk factor; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; gonadal steroids; high risk; inherited factor; insulin resistant; male; malignancy; model development; modifiable risk; neoplasm/cancer; obese; obese people; obese person; obese population; pathway; population based; precancerous state; public health relevance; screening; screenings; sex steroid; smoke cigarette; social role; whole genome association studies; whole genome association study",Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)," The incidence of esophageal adenocarcinoma, a rapidly fatal disease, has increased more than six-fold over the past 30 years. By conducting a large-scale genome-wide association study using pooled data and DNA from 18 epidemiologic studies, we propose to evaluate the influence of genetic susceptibility on risk of this cancer and its main precancerous condition, Barrett's esophagus, and determine the extent to which susceptibility factors vary according to key environmental and host risk factors for these conditions. These results will aid in the identification of biological pathways important in the etiology of this cancer, and help target persons at highest risk so that screening, prevention and surveillance efforts can be directed most effectively.",136725,ZRG1,Special Emphasis Panel,A1S1,1,1983520,
8010499,R01,DA,3,,07/01/2007,06/30/2010,PA-03-126,3R01DA017294-04S1,,NIDA:53624;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SUCHMAN, NANCY E;",1875693;,3R01DA017294,08/20/2004,06/30/2010,"0-11 years old; 4 year old; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Adaptation, Psychologic; Adaptation, Psychological; Adherence; Adherence (attribute); Adolescent; Adolescent Youth; Age; Alcohol Drinking; Alcohol consumption; Alcohols; Attention; Behavior; Behavioral; Caring; Characteristics; Chemical Class, Alcohol; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cognitive; Competence; Conditional Variables; Consult; Cues; Curriculum; Development; Diagnosis; Drug Therapy; Drugs; Drugs, Illicit; Educational Curriculum; Effect Modifiers (Epidemiology); Emotional; Enrollment; EtOH drinking; Feeling; Fostering; Human Maternal Behavior; Human, Child; Illicit Drugs; Individual; Infant; Instruction; Intervention; Intervention Strategies; Learning; Life; MT-bound tau; Manuals; Mediating; Medication; Methods and Techniques; Methods, Other; Moderator Variables; Modifiers, Epidemiologic Effect; Monitor; Mother-Child Relations; Mother-Child Relationship; Mothers; Out-patients; Outcome; Outpatients; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting behavior; Parents; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Pilot Projects; Preparation; Process; Programs (PT); Programs [Publication Type]; Psychiatric therapeutic procedure; Psychological adjustment; Randomized; Research; Risk; School-Age Population; Services; Staging; Symptoms; Techniques; Testing; Therapeutic; Thinking; Thinking, function; Training; Training Programs; Woman; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; children; clinical investigation; daily functioning; drug/agent; efficacy trial; enroll; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; feelings; four year old; improved; intervention development; interventional strategy; juvenile; juvenile human; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; mother child interaction; parent child interaction; parent offspring interaction; parental role; pilot study; programs; psychiatric care; psychiatric therapy; psychiatric treatment; psychologic; psychological; psychosocial adjustment; randomisation; randomization; randomly assigned; response; role of parent; school age; success; tau; tau Proteins; tau factor; therapy development; treatment development; youngster",Fostering Mothers' Emotionally-Responsive Parenting,,17294,PDRP,"Psychosocial Development, Risk and Prevention Study Section",S1,4,53624,
8011772,R01,DA,3,,02/01/2010,01/31/2011,PA-07-070,3R01DA024872-02S1,,NIDA:16683;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,FARMINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"ONCKEN, CHERYL ;",6879328;,3R01DA024872,02/01/2009,01/31/2014,"Abstinence; Address; Adherence; Adherence (attribute); Aerobic Activity; Aerobic Exercise; Affect; Age; Age-Years; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bone Density; Bone Mineral Density; CDC; Cancers; Cardiovascular Diseases; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation Research; Cessation of Treatment; Cessation of smoking; Cigarette; Conditioning Therapy; Connecticut; Counseling; Coxa; Department of Health and Human Services; Department of Health and Human Services (U.S.); Depressed mood; Depression; Diagnosis; Exercise; Exercise, Physical; Female; Fracture; HHS; Health; High Prevalence; Hip; Hip region structure; History; Life Style Modification; Lung diseases; Malignant Neoplasms; Malignant Tumor; Measurement; Meditation; Mental Depression; Methods; Minnesota; Moderate Activity; Moderate Exercise; Osteoporosis; Outcome; Physical activity; Population; Populations at Risk; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Programs (PT); Programs [Publication Type]; Pulmonary Diseases; Pulmonary Disorder; QOL; Quality of life; Randomized; Recording of previous events; Relaxation; Research; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Risk; SUBGP; Self Efficacy; Site; Smoke; Smoker; Smoking; Subgroup; Symptoms; System; System, LOINC Axis 4; Technology; Time; Treatment outcome; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Universities; Voice; Weight Gain; Weight Increase; Withholding Treatment; Woman; base; behavior intervention; behavioral intervention; body weight gain; body weight increase; bone fracture; cardiovascular disorder; cease smoking; compare effectiveness; depressed; improved; interest; lung disorder; malignancy; mindfulness; neoplasm/cancer; nicotine craving; non-smoking; older women; post-menopausal; postmenopausal; programs; public health relevance; randomisation; randomization; randomly assigned; reproductive; resistant; response; sadness; smoking cessation; treatment program; varenicline; wt gain",Exercise in Smoking Cessation in Postmenopausal Women," Thirty percent of female smokers are postmenopausal, and this proportion is expected to grow as the population ages. An effective exercise program added to smoking cessation for postmenopausal women has the potential to increase smoking cessation rates, address many health problems in this at-risk population, and markedly improve quality of life.",24872,ZDA1,Special Emphasis Panel,S1,2,16683,
8009683,R01,DK,3,Y,01/19/2010,03/31/2010,,3R01DK019974-32S1,,NIDDK:55700;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PHARMACOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"HINKLE, PATRICIA M.;",1959294;,3R01DK019974,01/19/2010,03/31/2010,"5-Oxo-L-prolyl-L-histidyl-L-prolinamide; Acute; Address; Adenohypophysis; Animals; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Antibodies; Arrestins; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Bolus; Bolus Infusion; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chemotherapy-Hormones/Steroids; Common Rat Strains; Cultured Cells; Cytoplasmic Membrane; Dephosphorylation; Dimerization; Dissociation; EC 2.7; ELISA; Endocrine Gland Secretion; Endocytic Vesicle; Endocytosis; Endocytotic Vesicle; Endosomes; Enzyme-Linked Immunosorbent Assay; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Goals; Head and Neck, Thyroid; Hormones; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Intracellular Communication and Signaling; Kinases; Knockout Mice; LTH; Label; Lactogenic Hormone, Pituitary; Learning; Mammals, Rats; Mammotropic Hormone, Pituitary; Mammotropin; Measures; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Mole the mammal; Molecular Interaction; Moles; Mutate; Nervous System, Pituitary; Null Mouse; Nutrition; Nutritional Science; Organelles; Output; PRL; PRL (Prolactin); Pars Anterior Pituitary Gland; Pathway interactions; Pattern; Phosphates; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiologic pulse; Physiological; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Plasma Membrane; Prolactin; Protein Dephosphorylation; Protein Dimerization; Protein Phosphorylation; Protirelin; Protyreline; Pulse; Pyr-His-ProNH2; Rat; Rattus; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, Protirelin; Receptors, Thyrotropin-Releasing Hormone; Receptosomes; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Recycling; Role; Science of nutrition; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Staining method; Stainings; Stains; Surface; TRH; TRH Receptors; Techniques; Temperature; Testing; Therapeutic Hormone; Thyreotropin; Thyroid; Thyroid Gland; Thyroid Stimulating Hormone; Thyroid-Releasing Hormone; Thyroid-Stimulating Hormone; Thyroliberin Receptors; Thyrotropin; Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone Receptors; Tissues; Transphosphorylases; arr3; arrestin 3; arrestin3; beta-arrestin; biological signal transduction; desensitization; experiment; experimental research; experimental study; hypothalamic; immunocytochemistry; in vivo; inorganic phosphate; luteotropic hormone; luteotropin; mutant; nutrition; pathway; plasmalemma; receptor; receptor internalization; receptor recycling; research study; response; social role; stoichiometry; trafficking",Modulation of Receptor Number in Cultured Cells,,19974,MCE,Molecular and Cellular Endocrinology Study Section,S1,32,55700,
8001406,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK028312-30S1,,NIDDK:251444;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLOTTESVILLE,UNITED STATES,PHARMACOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"GARRISON, JAMES CARLTON;",1892220;,3R01DK028312,01/15/2010,12/31/2010,"ATP-protein phosphotransferase; Actins; Adipocytes; Adipose Cell; Affect; Agarose; Animals; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Matrix; Chromatography; Chromatography / Separation Science; Complex; Cytoskeletal System; Cytoskeleton; Defect; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; EC 2.7; Enzymes; Exhibits; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fat Cells; Fatty Liver; Fiber; GLUT4; GLUT4 gene; Gene Proteins; Gene Transcription; GeneHomolog; Generalized Growth; Genes; Genetic Transcription; Glucose Intolerance; Glycogen; Goals; Growth; Heart Diseases; Hepatic; Homolog; Homologous Gene; Homologue; Humulin R; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Isoforms; Kidney Diseases; Kinases; Knock-out; Knockout; Knockout Mice; Label; Lentivirinae; Lentivirus; Lipids; Lipocytes; Liver Steatosis; METBL; MODY; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Murine; Mus; Muscle; Muscle Fibers; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Mutagenesis, Site-Directed; Mutate; Myotubes; NIDDM; Nephropathy; Neuropathy; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Organism-Level Process; Organismal Process; Peptide Fingerprinting; Peptide Mapping; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Phosphopeptides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiologic Processes; Physiological Processes; Plant Resins; Programs (PT); Programs [Publication Type]; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Gene Products; Protein Isoforms; Protein Kinase; Protein Phosphorylation; Proteins; RAFT1 protein, human; RAPT1 protein, human; RNA Expression; Rapamune; Rapamycin; Rapamycin Target Protein; Renal Disease; Reporter; Research; Research Personnel; Researchers; Resins, Plant; Rhabdomyocyte; Role; Sepharose; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subfamily lentivirinae; System; System, LOINC Axis 4; T2D; T2DM; Targeted DNA Modification; Targeted Modification; Techniques; Testing; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transphosphorylases; Tripcellim; Trypsin; Two Hybrid; Type 2 diabetes; Type II diabetes; Virus-Lenti; Vision Disorders; Visual Disorder; Wild Type Mouse; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adipogenesis; adult onset diabetes; biological signal transduction; blood glucose regulation; experiment; experimental research; experimental study; gene product; genetic promoter element; glucose control; glucose homeostasis; glucose metabolism; glucose regulation; glucose transport; glycogen metabolism; glycogen synthase a kinase; heart disorder; hepatic steatosis; human FRAP1 protein; hydroxyalkyl protein kinase; in vitro Model; in vivo; insulin resistant; insulin signaling; intracellular skeleton; ketosis resistant diabetes; kidney disorder; knockout animal; lipid biosynthesis; lipin; lipine; lipogenesis; mTOR; maturity onset diabetes; neuropathic; ontogeny; overexpression; oxidation; peripheral blood vessel disorder; phosphorylase b kinase kinase; programs; rapamycin and FKBP12 target 1 protein, human; renal disorder; research study; resin; response; shRNA; short hairpin RNA; small hairpin RNA; social role; trafficking; transcription factor; yeast two hybrid system",Insulin Action in Muscle and Fat Cells,,28312,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,30,251444,
8011809,R01,DK,3,Y,01/20/2010,01/19/2011,PA-07-023,3R01DK039753-17S1,,NIDDK:68786;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,ANATOMY/CELL BIOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"SUN, TUNG-TIEN ;",1881153;,3R01DK039753,01/20/2010,01/19/2011,"Acute; Antibiotic Resistance; Antibodies; Antigenic Determinants; Apical; Apoptosis; Apoptosis Pathway; Applications Grants; Area; Bacteria; Bacterial Infections; Binding; Binding (Molecular Function); Binding Determinants; Biochemistry; Biological Function; Biological Process; Biology; Bladder; Bladder Transitional Cell Epithelium; Bladder Urothelium; Blood; CDK6 Inhibitor p18; CDK6-associated protein p18; CDKN2C; CDKN2C Protein; CDKN6; Cancer of Bladder; Cancer of Urinary Bladder; Cell Death, Programmed; Cell Function; Cell Process; Cell Surface Proteins; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemistry, Biological; Clinical; Complex; Cyclin-Dependent Inhibitor; Cyclin-Dependent Kinase 4 Inhibitor C; Cyclin-Dependent Kinase 6 Inhibitor; Cyclin-Dependent Kinase 6 Inhibitor p18; Cyclin-Dependent Kinase Inhibitor 2C; Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4); Data; Defect; Dysplasia; E coli; Employee Strikes; Endocytosis; Epitopes; Escherichia coli; Exocytosis; Funding; Goals; Grant Proposals; Grants, Applications; INK4C; INK4C protein; Interstitial Cystitis; Invaded; Isoforms; Kidney; Lead; Little's Disease; Location; MDCK cell; Madin Darby canine kidney cell; Malignant Bladder Neoplasm; Malignant Tumor of the Bladder; Malignant neoplasm of urinary bladder; Mediating; Membrane; Membrane Protein Traffic; Membrane Proteins; Membrane Traffic; Membrane-Associated Proteins; Microbe; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Names; Nature; New Territories; Obstructive Uropathy; Occluding Junctions; Outcome; Pathway interactions; Pb element; Permeability; Physiologic; Physiological; Play; Position; Positioning Attribute; Process; Protein Isoforms; Proteins; Proteins, Cell Surface; Receptor Protein; Recurrence; Recurrent; Recycling; Regulation; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Blood; Retrieval; Role; Sorting - Cell Movement; Spastic Diplegia; Spastic Diplegias; Strikes; Strikes, Employee; Structure; Subcellular Process; Surface; Surface Proteins; System; System, LOINC Axis 4; Testing; Tight Junctions; Time; UP II protein, human; UP III protein, human; UPEC; UPII gene product; UTI; Urinary Bladder Malignant Tumor; Urinary System, Bladder; Urinary System, Kidney; Urinary System, Urine; Urinary Tract Diseases; Urinary tract infection; Urinary tract infectious disease; Urination; Urine; Urologic Diseases; Urologic Disorder; Urological Diseases; Urological Disorders; Uropathogenic E coli; Uropathogenic E. coli; Uropathogenic E.coli; Uropathogenic Escherichia coli; Urothelial Cell; Urothelium; VESCL; Vesicle; Work; Zonula Occludens; antibiotic resistant; bacterial disease; cDNA Library; cerebral spastic infantile paralysis; conformation; conformational state; cyclin-dependent kinase inhibitor p18; dyscrasia; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; membrane structure; micturition; nexin; novel; p18; p18 protein; p18-INK4C; p18-INK6; p18INK4c protein; particle; pathway; receptor; renal; social role; sorting; sorting nexins; trafficking; uRNA; urinary bladder; urinary tract disorder; urinary tract obstruction; uroplakin II; uroplakin III; voiding",Biochemistry of Urothelial Differentiation,,39753,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,S1,17,68786,
8010059,R01,DK,3,Y,01/15/2010,03/31/2010,PA-03-147,3R01DK040890-19S1,,NIDDK:8950;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,UROLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"PRINS, GAIL S;",1862751;,3R01DK040890,01/15/2010,03/31/2010,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; ATRA; Adenocarcinoma; Adenoma, Malignant; Age; Aging; All-trans retinoic acid; Androgenic Agents; Androgenic Compounds; Androgens; Animals; Body Tissues; Carcinoma of prostate; Cell Communication and Signaling; Cell Signaling; Cells; Chemotherapy-Hormones/Steroids; Common Rat Strains; Complex; Corpus Luteum Hormone; Critical Period; Critical Period (Psychology); Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Cytology; Data; Defect; Delta4-pregnene-3,20-dione; Development; Developmental Gene; Diathesis; Disease; Disease susceptibility; Disorder; Dose; Dysplasia; Endocrine Gland Secretion; Epithelial; Epithelial Cells; Epithelial-Stromal Communication; Epithelial-Stromal Interaction; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exhibits; Family; Gene Expression; Gene, Developmental; Generalized Growth; Genes; Genital System, Female, Uterus; Genital System, Male, Prostate; Gland; Glycoproteins; Goals; Growth; Hormonal; Hormones; Human; Human Prostate; Human Prostate Gland; Human, General; Hyperplasia; Hyperplastic; In Vitro; Incidence; Intracellular Communication and Signaling; Investigation; Lead; Lesion; Life; Lobe; Mammals, Rats; Mammals, Rodents; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Transgenic; Modeling; Molecular; Morphogenesis; Morphology; Movement; Neonatal; Organ; Organ Culture; Organ Culture Techniques; Organogenesis; Pathologic; Pathway interactions; Pattern; Pb element; Phenotype; Play; Predisposing Factor; Pregn-4-ene-3,20-dione; Pregnenedione; Process; Progesterone; Programs (PT); Programs [Publication Type]; Prostate; Prostate Disease; Prostate Gland; Prostate carcinoma; Prostatic; Prostatic Diseases; Prostatic Gland; Prostatic Intraepithelial Neoplasia of the Prostate Gland; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasms; Prostatic carcinoma; Prostatic intraepithelial neoplasia; Rat; Rattus; Receptor Protein; Receptors, Steroid; Regulation; Research; Retinoic Acid; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Rodent; Rodent Model; Rodentia; Rodentias; Role; Senescence; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Steroid Compound; Steroid Receptors; Steroids; Structure; System; System, LOINC Axis 4; Therapeutic Androgen; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Tissue Growth; Tissues; Trans Vitamin A Acid; Transgenic Mice; Tretinoin; Tretinoinum; Uterus; Vitamin A Acid; Withdrawal; all-trans-Retinoic Acid; all-trans-Vitamin A acid; base; biological signal transduction; body movement; cancer type; critical developmental period; disease/disorder; disease/disorder proneness/risk; dyscrasia; heavy metal Pb; heavy metal lead; imprint; in vivo Model; liability to disease; mammary; member; morphogens; ontogeny; pathway; programs; prostate disorder; prostate intraepithelial neoplasm; prostatic cancer, carcinoma; receptor; receptor expression; senescent; social role; trans-Retinoic Acid; womb",Development Estrogenization of the Rat Prostate Gland,,40890,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,S1,19,8950,
7992528,R01,DK,3,Y,01/01/2010,12/31/2010,,3R01DK046072-12S2,,NIDDK:45600;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"SCHWARTZ, JESSICA ;",1892141;,3R01DK046072,01/01/2010,12/31/2010,"AIDS; AIDS Virus; Acetylation; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Autocrine Systems; Binding; Binding (Molecular Function); Biological Models; Burn injury; Burns; CHIP assay; Cancers; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Clinic; Clinical; Code; Coding System; Complex; Diabetes Mellitus; Endogenous Factors; Enhancers; Event; FOS gene; Figs; Figs - dietary; G0S7; GHN; Gene Components; Gene Down-Regulation; Gene Expression; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Goals; Grant; Growth; Growth Hormone; Growth Hormone 1; Growth hormone excess; HIV; HTLV-III; Hormone Responsive; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Humulin R; Immunologic Deficiency Syndrome, Acquired; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; LAV-HTLV-III; Laboratories; Limulus factor C; Lymphadenopathy-Associated Virus; METBL; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic Processes; Metabolism; Model System; Modeling; Models, Biologic; Modification; Molecular Interaction; Molecular Target; Muscle; Muscle Tissue; Novolin R; Nuclear; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nucleoproteins; Nucleus; Patients; Phosphorylation; Physiologic; Physiological; Pituitary Growth Hormone; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-Translational Modifications; Post-Translational Protein Processing; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Protooncogene FOS; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Recovery; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Researchers; STH; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somatotrophin increased; Somatotropin; Subcellular Process; Targetings, Gene; Therapeutic; Therapeutic Uses; Time; Tissue Growth; Transcription; Transcription Activation; Transcription Regulation; Transcription Repression; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Transcriptional Repression; Up-Regulation; Virus-HIV; Wound Healing; Wound Repair; autocrine; base; biological signal transduction; c fos; c-fos Gene; c-fos Proto-Oncogenes; chromatin immunoprecipitation; cytokine; diabetes; effective therapy; factor C; gene product; gene repression; growth hormone deficiency; hGHN; horseshoe crab factor C; improved; in vivo; insight; insulin resistant; malignancy; neoplasm/cancer; ontogeny; peptide hormone; programs; recruit; response; somatotropic hormone; tissue repair; transcription factor; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; wasting",Growth Hormone Signaling to the Nucleus,,46072,MCE,Molecular and Cellular Endocrinology Study Section,S2,12,45600,
8012161,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK046285-10S1,,NIDDK:99997;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,SURGERY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"BUNNETT, NIGEL W;KIRKWOOD, KIMBERLY SAUNDERS (contact);",1865908;2091088 (contact);,3R01DK046285,02/01/2010,01/31/2011,"4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; Abdominal Pain; Active Oxygen; Adhesions; Afferent Neurons; Agonist; Aldehydes; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Anti Inflammatory; Animals; Anodynes; Anti Inflammatory Analgesics; Anti-Inflammatories; Anti-Inflammatory Agents; Antigens, Leukemia, Common Acute Lymphoblastic; Antiinflammatories; Antiinflammatory Agents; Antinociceptive Agents; Antinociceptive Drugs; Antiproteases; Arachidonic Acids; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Arterioles; Atriopeptidase; Attenuated; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Neutrophil; Blood Plasma; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Blood capillaries; Body Tissues; Bradykinin; CALLA Antigen; CD10 Antigens; CGRP; Calcitonin; Calcitonin Gene-Related Peptide; Calcitonin(1-32); Calcitrin; Canal of Wirsung; Capillaries; Capillary; Capillary, Unspecified; Cell Body; Cell Communication and Signaling; Cell Membrane Lipids; Cell Signaling; Cell surface; Cleaved cell; Common ALL Antigen; Common Rat Strains; Conditioning Therapy; Dorsal Horn of the Spinal Cord; Dorsal Root Ganglia; ECE-1; Endocytosis; Endopeptidase Inhibitors; Endopeptidase-24.11; Endosomes; Endothelial Cells; Endothelin-converting enzyme 1; Enkephalin Dipeptidyl Carboxypeptidase; Enkephalinase; Enkephalinase-24.11; Enzymes; Esteroproteases; Euler-Gaddum Substance P; Event; Experimental Models; Experimental Models, Other; Extracellular Fluid; Extravasation; Family; Fiber; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Ganglia, Spinal; Gastrointestinal Tract, Pancreas; Gated Ion Channel; Goals; Heterophil Granulocyte; Human; Human, General; Hyperemia; INFLM; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Intractable Pain; Ion Channel; Ionic Channels; Kassinin, 1-de-L-aspartic acid-2-de-L-valine-3-L-histidine-5-L-threonine-7-L-serine-; Kidney-Brush-Border Neutral Proteinase; Leakage; Learning; Life Style Modification; Ligands; Lipid Peroxidation; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medulla Spinalis; Membrane Channels; Membrane Lipids; Membrane Metallo-Endopeptidase; Membrane Metalloendopeptidase; Metallo-Endoproteinases; Metalloendopeptidases; Mice; Modeling; Models, Experimental; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NK-1 Receptors; NK1R; NKIR; Neprilysin; Nerve Cells; Nerve Growth Factors; Nerve Unit; Neural Cell; Neurocyte; Neurogenic Inflammation; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuronotrophic Factors; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropeptide Receptor; Neuropeptides; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Neutral Endopeptidase; Neutral Endopeptidase 24.11; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nociception; Oxygen Radicals; PAR-2 Receptor; PAR2 Receptor; PTK Receptors; Pain; Pain, Intractable; Painful; Pancreas; Pancreatic; Pancreatic duct; Pancreatitis; Pathway interactions; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Peptide Signal Sequences; Peptides; Peripheral; Plasma; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Pro-Oxidants; Process; Protease Antagonists; Protease Inhibitor; Protease-Activated Receptor 2; Proteases; Proteinase Activated Receptor 2; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; RTK; Rat; Rattus; Reactive Oxygen Species; Receptor Activation; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, PAR-2; Receptors, Neurokinin-1; Receptosomes; Recombinants; Recycling; Refractory Pain; Resistance; Reticuloendothelial System, Serum, Plasma; Role; SP(1-11); SP-P Receptors; Sensory; Sensory Cell Afferent Neuron; Sensory Nerve Endings; Serum, Plasma; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Spillage; Spinal; Spinal Cord; Spinal Ganglia; Spinal cord posterior horn; Stimulus; Stress; Structure of arteriole; Structure of venule; Substance K; Substance P; Substance P Receptor; Symptoms; TAC1R; TACR1; Tachykinin Receptor 1; Testing; Therapeutic; Therapeutic Agents; Thermolysin-Like Metalloendopeptidase; Thyrocalcitonin; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Tripcellim; Trypsin; Trypsin Receptor; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Vanilloid; Venules; Wild Type Mouse; YGG-Forming Enzyme; acute pancreatitis; afferent nerve; analgesia; arteriole; behavior intervention; behavioral intervention; biological signal transduction; capillary; cell body (neuron); cleaved; design; designing; dorsal root ganglion; experiment; experimental research; experimental study; inflammatory pain; inhibitor; inhibitor/antagonist; intractable pain syndrome; kallidin 9; kallidin I; kidney brush border neutral peptidase; lung injury; member; neural cell body; neural control; neural regulation; neurokinin 1; neuronal; neuronal cell body; neuroregulation; neutrophil; new therapeutics; next generation therapeutics; nociceptive; novel; novel therapeutics; overexpression; pathway; prevent; preventing; protein signal sequence; public health relevance; receptor; receptor recycling; receptor-activity-modifying protein; research study; resistant; sensory nerve; social role; soma; vascular; venule",Neural Regulation of Pancreatic Function,,46285,ZRG1,Special Emphasis Panel,S1,10,99997,
7986858,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK046974-16S1,,NIDDK:27656;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"DEMAY, MARIE ;",1865677;,3R01DK046974,02/01/2010,04/30/2010,"Ablation; Address; Alopecia; Apoptosis; Apoptosis Pathway; Assay; Attenuated; Autoregulation; BMP-2; BMP-2A; BMP2; Baldness; Bioassay; Biologic Assays; Biological Assay; Biological Models; Bone Development; Bone Formation; Cell Communication and Signaling; Cell Death, Programmed; Cell Lineage; Cell Signaling; Cells; Chondrocytes; Cutaneous; Development; Diet; Epiphyseal Plate; Epiphysial cartilage; Femoral Fractures; Fracture; Gene Expression; Genetics, in situ Hybridization; Goals; Growth Plate; Hair; Hair Follicle; Hair follicle structure; Histologic; Histologically; Homeostasis; Human; Human, General; Hyperparathyroidism, Secondary; Hypophosphatemia; Immune Precipitation; Immunoprecipitation; In Situ Hybridization; Intestinal; Intestines; Intracellular Communication and Signaling; Investigation; Ions; Knockout Mice; Life; Ligands; Long Bone; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Metatarsal Bones; Metatarsal bone structure; Metatarsals; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Minerals; Model System; Modeling; Models, Biologic; Molecular; Mother Cells; Murine; Mus; Natural regeneration; Nuclear Receptors; Null Mouse; Osteogenesis; Osteomalacia; Pathway interactions; Phosphates; Physiological Homeostasis; Play; Prevention; Progenitor Cells; Receptor Protein; Regeneration; Rickets; Role; Secondary Hyperparathyroidism; Secondary Hyperparathyroidisms; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Development; Skeleton; Staging; Stem cells; Structure of long bone; Study models; System; System, LOINC Axis 4; Transgenic Mice; Vitamins; base; biological signal transduction; bone fracture; bone morphogenetic protein 2; bowel; extracellular; femur fracture; in situ Hybridization Staining Method; in vivo; inorganic phosphate; keratinocyte; long bone; novel; pathway; postnatal; prevent; preventing; receptor; reconstitute; reconstitution; regenerate; repair; repaired; self-renewal; skeletal; social role",VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES,,46974,SBDD,Skeletal Biology Development and Disease Study Section,S1,16,27656,
8000156,R01,DK,3,Y,01/15/2010,07/31/2010,,3R01DK047814-15S1,,NIDDK:82786;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HOLDEN, HAZEL ;",1873059;,3R01DK047814,01/15/2010,07/31/2010,"3,6-dideoxy-D-arabino-hexose; 3,6-dideoxy-L-xylo-hexose; ATGN; Affect; Anabolism; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antigens; Biochemical; Biological; Biological Function; Biological Process; C element; Carbohydrates; Carbon; Cell Adhesion; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Chimera Protein; Chimeric Proteins; Clinical; D-Galactose; Defect; Deoxy Sugars; Disease; Disorder; E-Mycin; Enzyme Gene; Enzymes; Ery-Tab; Eryc; Eryderm; Erythrocin; Erythromycin; Erythromycin A; Fertility/Fertilization; Fertilization; Foundations; Funding; Fusion Protein; Galactopyranose; Galactopyranoside; Galactose; Galactosemia; Galactosemias; Gene Transcription; Genes; Genetic; Genetic Transcription; Goals; Gram-Negative Bacteria; Grant; Ilotycin; Immune response; Impairment; In element; Indium; Intermediary Metabolism; Investigation; Laboratories; Lead; Leloir Pathway of Galactose Metabolism; METBL; Macrolide Antibiotics; Metabolic; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Miscellaneous Antibiotic; Molecular; Mutagenesis, Site-Directed; Nature; O Antigen, Bacterial; O Antigens; O-Specific Polysaccharides; Organism; Organism-Level Process; Organismal Process; Pathogenicity; Pathway interactions; Pb element; Pediamycin; Physiologic Processes; Physiological Processes; Play; Proteins; RNA Expression; RP-Mycin; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Research; Robimycin; Roentgen Rays; Role; S cerevisiae; Saccharomyces cerevisiae; Severities; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Techniques; Transcription; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Regulation; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repressor; Transcriptional Repressor/Corepressor; X-Radiation; X-Rays; Xrays; Yeast, Baker's; Yeast, Brewer's; Yeasts; anti-microbial agent; anti-microbial drug; antimicrobial agent; antimicrobial drug; ascarylose; base; biosynthesis; colitose; deoxysugar; design; designing; desosamine; dideoxyhexose; disease/disorder; gene product; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; interest; living system; pathway; social role; sugar; tyvelose",X-ray Studies of Sugar-Modifying Enzymes,,47814,MSFB,Macromolecular Structure and Function B Study Section,S1,15,82786,
8003246,R01,DK,3,Y,01/11/2010,01/11/2011,PA-02-011,3R01DK047858-13S1,,NIDDK:62928;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GAINESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"SIMPSON, NICHOLAS E;",1942780;,3R01DK047858,01/11/2010,01/11/2011,"Address; Adenoma, beta-Cell; Agarose; Alginates; Anatomic; Anatomical Sciences; Anatomy; Beta Cell; Beta Cell Neoplasm; Beta Cell Neoplasm of the Pancreas; Beta Cell Tumor of the Pancreas; Bioenergetic; Bioenergetics; Cell Communication and Signaling; Cell Density; Cell Nucleus; Cell Signaling; Cells; Characteristics; Coupled; D-Glucose; Data; Density, Cell; Dextrose; Diabetes Mellitus; Encapsulated; Event; FLR; Failure (biologic function); Gastrointestinal Tract, Pancreas; Generalized Growth; Glucose; Growth; Hypoxia; Hypoxic; Image; Imaging Procedures; Imaging Techniques; Implant; In Vitro; Insulin Cell; Insulin Secreting Cell; Insulin-Producing Neoplasm of the Islet Cells; Insulin-Producing Tumor of the Islet Cells; Insuloma; Intermediary Metabolism; Intracellular Communication and Signaling; METBL; Mammals, Mice; Metabolic; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice; Modality; Modeling; Monitor; Murine; Mus; Nucleus; O element; O2 element; Oxygen; Oxygen Deficiency; Pancreas; Pancreatic; Pancreatic Beta Cell Insulin Producing Neoplasm; Pancreatic Beta Cell Insulin Producing Tumor; Pancreatic Beta Cell Tumor; Physiologic; Physiological; Physiology; RF coil; Research; Research Design; Retrieval; Role; Science of Anatomy; Sepharose; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Structure; Study Type; Study models; Technics, Imaging; Techniques; Tet; Tetanus Helper Peptide; Time; Tissue Engineering; Tissue Growth; Treatment Efficacy; anatomy; base; beta-Cell Tumor; biological signal transduction; cell fixation; design; designing; diabetes; engineered tissue; experiment; experimental research; experimental study; extracellular; failure; imaging; implantation; in vivo; indexing; insulin secretion; insulinoma; islet; ontogeny; poly-L-lysine alginate; research study; restoration; social role; spectroscopic imaging; study design; therapeutic efficacy; therapeutically effective",A study of model beta-cells in Diabetes Treatment,,47858,MTE,Musculoskeletal Tissue Engineering Study Section,S1,13,62928,
8010054,R01,DK,3,Y,01/18/2010,12/31/2010,,3R01DK050107-13S1,,NIDDK:99266;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,PHARMACOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"BRESNICK, EMERY H.;",6396285;,3R01DK050107,01/18/2010,12/31/2010,"Assay; B-globin; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cells; ChIP (chromatin immunoprecipitation); Chemicals; Chromatin; Chromatin Structure; Chromosomes; Code; Coding System; Complex; Computer Analysis; Coupled; DNA Binding; DNA Binding Interaction; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; ERYF1; ERYF1 protein, human; Elements; Erythroid Transcription Factor; Erythropoiesis; Event; GATA Binding Protein 1; GATA binding protein 1, human; GATA-1; GATA1; GATA1 protein, human; GF1; Gene Transcription; Generations; Genetic; Genetic Transcription; Genomics; Globin; Goals; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Hemoglobin; Human; Human, General; Individual; Kinetic; Kinetics; Life; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Molecular; Molecular Interaction; Murine; Mus; NFE1; Nucleoproteins; Pathway interactions; Physiologic; Physiological; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reaction; Regulation; Sequence-Specific Posttranscriptional Gene Silencing; Site; Staging; Structure; Technology; Testing; Transcription; Transcription Activation; Transcription Factor GATA1; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Up-Regulation; beta Globin; chromatin immunoprecipitation; chromatin protein; clinical data repository; clinical data warehouse; computational analysis; data repository; erythrold transcription factor 1; gene product; globin transcription factor 1; globin transcription factor 1, human; histone modification; human GATA1 protein; inhibitor; inhibitor/antagonist; insight; mutant; novel; p-Globin; pathway; programs; protein protein interaction; relational database; transcription factor",Transcriptional Control of Hemoglobin Synthesis,,50107,ZRG1,Special Emphasis Panel,S1,13,99266,
8011273,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK050189-16S1,,NIDDK:103093;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"COLGAN, SEAN P;",1881132;,3R01DK050189,02/01/2010,01/31/2011,"5' ribonucleotide phosphohydrolase; 5'-AMP Nucleotidase; 5'-N'Tase; 5'-NT; 5'-Nucleotidase; 5'-Nucleotidase Phosphoribolase; ABC20; ABCB1; ABCB1 gene; AMP Phosphatase; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Gene; ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; Adenine Nucleotides; Adenosine; Adenosine Phosphates; Adenylate Phosphatase; Anatomic; Anatomical Sciences; Anatomy; Antigens, CD55; Apical; Bears; Binding Sites; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Blood flow; Blood leukocyte; Blood monocyte; Body Tissues; CD55 Antigens; CD73 Antigens; Cell Communication and Signaling; Cell Signaling; Cola; Colitis; Combining Site; Cytidylate Phosphatase; Decay-Accelerating Factor; Disease; Disorder; Ecto-5'-Nucleotidase; Elements; Enzymes; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Event; GP170; Generations; Genes; Genus Cola; Gut Inflammation; Health; Heterophil Granulocyte; Hypoxia; Hypoxia Inducible Factor; Hypoxic; IMP Nucleotidase; IMP Phosphatase; IMPase; INFLM; ITF protein; In Vitro; Inflammation; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Inosinate Phosphatase; Intermediary Metabolism; Intestinal; Intestinal Diseases; Intestinal Disorder; Intestinal Inflammation; Intestines; Intracellular Communication and Signaling; Ischemia-Reperfusion Injury; Leukocyte Trafficking; Leukocytes; Ligands; Location; Lung; MDR-1; MDR1; MDR1 Gene; MDR1 Protein; METBL; Mammals, Mice; Marrow Neutrophil; Marrow leukocyte; Marrow monocyte; Measures; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic; Metabolic Processes; Metabolic acidosis; Metabolism; Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids; Mice; Mice, Transgenic; Modeling; Molecular; Mucosa; Mucosal Inflammation; Mucosal Tissue; Mucositis; Mucous Membrane; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Murine; Mus; Myeloid Cells; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nucleotide Synthesis; O element; O2 element; Organ; Oxygen; Oxygen Deficiency; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein 1 Gene; P-Glycoprotein Transporter; P-Glycoproteins; P1 Purinoceptors; PGY-1 Protein; PGY1; Pathway interactions; Phenotype; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Purinergic P1 Receptors; Pyrimidine 5'-Nucleotidase; Reactive Site; Receptors, Adenosine; Receptors, Purinergic P1; Regulation; Reperfusion Damage; Reperfusion Injury; Resistance Gene-1, Multidrug; Resistance Gene-1s, Multidrug; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Role; Science of Anatomy; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Structure of intestinal epithelium; Surface; Surface Proteins; Testing; Thymidine Phosphatase; Tissues; Transgenic Mice; Uridylate 5'-Nucleotidase; Ursidae; Ursidae Family; White Blood Cells; White Cell; Work; anatomy; apical membrane; base; biological signal transduction; bowel; cell type; disease/disorder; extracellular; gain of function; gene product; in vitro Model; in vivo; insight; intestinal epithelium; intestinal trefoil factor; intestine disorder; membrane structure; monocyte; neutrophil; nucleotide metabolism; pathway; programs; pulmonary; response; social role; trafficking; transcription factor; trefoil factor; vascular; white blood cell; white blood corpuscle",Role of Epithelia In Ischemia Reperfusion Injury,,50189,ZRG1,Special Emphasis Panel,S1,16,103093,
8011784,R01,DK,3,Y,01/20/2010,01/19/2011,PA-07-070,3R01DK051369-12S1,,NIDDK:67074;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BURLINGTON,UNITED STATES,NEUROLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"VIZZARD, MARGARET ANN;",1895354;,3R01DK051369,01/20/2010,01/19/2011,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Affinity; Area; BMK1; Backcrossings; Binding; Binding (Molecular Function); Biological; Bladder; Bladder Control; Bladder Dysfunction; Budgets; CNS plasticity; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Central Canal; Central Canal of Spinal Cord; Central cord canal structure; Chimp; Chimpanzee; Chronic; Clinical; Common Rat Strains; Complex; Connector Neuron; Conscious; Consciousness; Cystitis; Dorsal Root Ganglia; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7.2-; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERK MAP Kinases; ERK1; ERK2; ERK4; ERK5; ERT1; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Esthesia; Event; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Extremities; Figs; Figs - dietary; Frequencies (time pattern); Frequency; Future; GFAC; GP80-LNGFR; Ganglia; Ganglia, Spinal; Ganglion Cysts; Ganglionic Cysts; Ganglions; Growth Agents; Growth Factor; Growth Factor Interaction; Growth Factors, Proteins; Growth Substances; HEK3; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; Increased frequency of micturition; Infection; Inflammation; Inflammatory; Instillations, Bladder; Intercalary Neuron; Intercalated Neurons; International; Interneurons; Internuncial Cell; Internuncial Neuron; Interstitial Cystitis; Intracellular Communication and Signaling; Intravesical Instillation; Ligands; Limb structure; Limbs; Lower urinary tract; MAP kinase; MAPK; MAPK1; MAPK1 gene; MAPK2; MAPK3; MAPK3 gene; MAPK7; MAPK7 gene; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Mediating; Medulla Spinalis; Membrane; Methods and Techniques; Methods, Other; Mice; Micturition Reflex; Mitogen-Activated Protein Kinase 3 Gene; Mitogen-Activated Protein Kinases; Modeling; Molecular Interaction; Motor Cell; Motor Neurons; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Myxoid cyst; NGF Receptor; NGFR; NGFR Protein; NTRK1; NTRK1 Receptor; Nerve; Nerve Cells; Nerve Growth Factor Receptor Type 1; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity; Nerve Growth Factor Receptors; Nerve Growth Factors; Nerve Unit; Nervous; Neural Cell; Neural Ganglion; Neural Transmission; Neurochemistry; Neurocyte; Neuronal Plasticity; Neuronotrophic Factors; Neurons; Neuropeptides; Neurotrophic Factor Receptor; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophic Tyrosine Kinase Receptor Type 1; Neurotrophins; Neurotropin Receptor p75; Non-Trunk; Nucleus; P41MAPK; P42MAPK; P44ERK1; P44MAPK; PAC1 receptor; PACAP; PACAP type I receptor; PACAPR-1 protein; PI-3 Kinase; PI-3K; PI3-Kinase; PRKM1; PRKM2; PRKM7; PTK; Pain; Painful; Pan; Pan Genus; Pan Species; Pathology; Pathway interactions; Pelvic; Pelvic Pain; Pelvic Region; Pelvis; Peripheral; Peripheral Nervous System; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Play; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Process; Property; Property, LOINC Axis 2; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proto-Oncogene Products c-trk; PtdIns 3-Kinase; Rat; Rattus; Receptor Activation; Receptor Protein; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Recommendation; Reflex; Reflex action; Research Proposals; Rodent; Rodentia; Rodentias; Role; Science of neurochemistry; Secondary to; Sensation; Sensory Physiology; Sensory Process; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth muscle (tissue); Societies; Spinal; Spinal Cord; Spinal Ganglia; Stimulus; Symptoms; Synapses; Synaptic; Synaptic Transmission; Syndrome; System; System, LOINC Axis 4; Techniques; Therapeutic Intervention; Threonine/Tyrosine Protein Kinase; Time; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; U-0126; U0126; U0126 cpd; UO-126; UO126; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urethral sphincter; Urinary Frequency; Urinary System, Bladder; Urinary System, Urine; Urination; Urine; Urothelium; Visceral; Woman; Work; allodynia; biological signal transduction; bladder continence; c-trk Protein; defined contribution; dorsal horn; dorsal root ganglion; experiment; experimental research; experimental study; extracellular signal related kinase; gene product; gp140(c-TRK); gp75 NGFR; hydroxyaryl protein kinase; inhibitor; inhibitor/antagonist; insight; intervention therapy; membrane structure; micturition; micturition control; motoneuron; multidisciplinary; neural control; neural plasticity; neural regulation; neurochemistry; neuronal; neuroplasticity; neuroregulation; neurotrophic factor; neurotrophin; neutrophin; novel; overexpression; p140-trkA; p75; p75 neurotrophin receptor; p75 transcription factor; p75(NTR); p75NTR; painful bladder syndrome; pathway; pituitary adenylate cyclase activating peptide; pituitary adenylate cyclase activating polypeptide; pituitary adenylate cyclase-activating peptide receptor, type I; protein expression; public health relevance; receptor; receptor expression; research study; social role; spinal reflex; tool; transcriptional coactivator p75; trk Proto-Oncogene Protein; trk1 Transforming Tryrosine Kinase; tyrosyl protein kinase; uRNA; urinary bladder; urinary continence; urinary control; urination control; voiding; voiding reflex",Cystitis-Induced Plasticity of Micturition Reflexes,,51369,ZRG1,Special Emphasis Panel,S1,12,67074,
7996764,R01,DK,3,Y,01/01/2010,03/31/2010,,3R01DK051562-14S1,,NIDDK:4000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLOTTESVILLE,UNITED STATES,PSYCHIATRY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"KOVATCHEV, BORIS P.;",2233176;,3R01DK051562,01/01/2010,03/31/2010,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; Adrenaline; Adverse Experience; Adverse event; Affect; Antidiabetic Hormone; Automobile Driving; Awareness; Awarenesses; Behavior Conditioning Therapy; Behavior Control; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Manipulation; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Circulation; Blood Glucose Self-Monitoring; Blood Sugar Self-Monitoring; Blood Vessels; Blood capillaries; Bloodstream; Capillaries; Capillary; Capillary, Unspecified; Characteristics; Chemotherapy-Hormones/Steroids; Chronic; Circulation; Clinical; Computer Simulation; Computerized Models; Conditioning Therapy; D-Glucose; Data; Data Collection; Development; Dextrose; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diagnosis, Ultrasound; Drivings, Automobile; Echography; Echotomography; Endocrine; Endocrine Gland Secretion; Endocrine system; Endocrine system (all sites); Endocrine/Metabolic Organ System; Endothelium; Environment; Epi; Epinephrine; Exercise; Exercise, Physical; FLR; Failure (biologic function); Fear; Feedback; Frequencies (time pattern); Frequency; Fright; GCG; Glucagon; Glucagon (1-29); Glucose; Glukagon; Glycohemoglobin A; Glycosylated hemoglobin A; Grant; HG-Factor; Hb A1; Hb A1a+b; Hb A1c; HbA1; HbA1c; Health; Hemoglobin A(1); History; Hormonal; Hormonal System; Hormones; Humulin R; Hyperglycemia; Hyperglycemic-Glycogenolytic Factor; Hypoglycemia; IDD; IDDM; Impairment; Incidence; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intervention; Intervention Strategies; Investigation; Laboratories; Laboratories, Hospital; Life Style Modification; Maintenance; Maintenances; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Medical Imaging, Ultrasound; Metabolic/Endocrine Body System; Methods; Modeling; Models, Computer; Monitor; Monitoring, Home Blood Glucose; Muscle; Muscle Tissue; Novolin R; Outcome; Outcome Study; Patients; Pattern; Perfusion; Permeability; Phase; Physiologic; Physiological; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Recording of previous events; Recruitment Activity; Recurrence; Recurrent; Regulation; Relative; Relative (related person); Research; Risk; Simulation, Computer based; Stochastic Processes; Study, Outcome; Symptoms; System; System, LOINC Axis 4; Systems Biology; T1 diabetes; T1D; T1DM; Testing; Therapeutic Epinephrine; Therapeutic Hormone; Time; Translating; Translatings; Type 1 diabetes; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Work; base; behavior intervention; behavioral control; behavioral intervention; biobehavior; biobehavioral; capillary; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; counterregulation; design; designing; diagnostic ultrasound; driving; endocrine gland/system; experience; experiment; experimental research; experimental study; failure; field study; glycemic control; hemoglobin A1c; high risk; hospital laboratories; hyperglycemic; hypoglycemic; hypoglycemic episodes; improved; in silico; indexing; insight; insulin dependent diabetes; insulin sensitivity; interstitial; interventional strategy; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; language translation; model development; network models; programs; prospective; recruit; research study; response; sonogram; sonography; sound measurement; type I diabetes; ultrasound; ultrasound imaging; ultrasound scanning; vascular; virtual simulation",Bio-Behavioral Feedback and Control of Type 1 Diabetes,,51562,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",S1,14,4000,
7992506,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK051817-13S1,,NIDDK:13000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STANFORD,UNITED STATES,PSYCHOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"WINE, JEFFREY J;",1867626;,3R01DK051817,02/01/2010,04/30/2010,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3'5'-cyclic ester of AMP; Acetylcholine; Acinus organ component; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Anions; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apical; Axon; Bacteria; Bicarbonates; Body Tissues; Buffers; CF lung disease; CFTR; CFTR Protein; Cataloging; Catalogs; Cell Shape; Cell model; Cell secretion; Cells; Cellular Secretion; Cellular model; Chemicals; Chronic; Coleonol; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cystic Fibrosis, Pulmonary; Data; Defect; Denervation; Duct; Duct (organ) structure; Ductal; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Event; Exocytosis; Fluids and Secretions; Forskolin; Gland; H+ element; HCO3; His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn; Human; Human, General; Hydrogen Carbonates; Hydrogen Ions; Image; Individual; Infection; Ion Channel; Ion Transport; Ionic Channels; Ions; Killings; Knowledge; Krebs solution; Krebs-Ringer solution; Left; Liquid substance; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane Channels; Methods; Microscopy; Mitochondria; Molecular Transport; Mucous body substance; Mucoviscidosis; Mucus; Myoepithelial; Nerve Cells; Nerve Unit; Neural Cell; Neural Pathways; Neurocyte; Neurons; Optical Methods; Optics; PHM27; Pathway interactions; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Secretion; Protons; Pulmonary Cystic Fibrosis; RT-PCR; RTPCR; Receptor Protein; Reflex; Reflex action; Refractory; Research; Resolution; Reverse Transcriptase Polymerase Chain Reaction; Role; Series; Serous; Solutions; Stimulus; Structure; Surface; Testing; Time; Tissues; Transplant Recipients; Transport Process; Trees; VIP; Vasoactive Intestinal Peptide; Vasoactive Intestinal Polypeptide; Vasointestinal Peptide; Wine; Work; acinus; adenosine 3'5' monophosphate; anti-microbial; antimicrobial; cAMP; cell imaging; cellular imaging; cholinergic; computer imaging; cystic fibrosis lung disease; cystic fibrosis transmembrane regulator; digital imaging; experiment; experimental research; experimental study; fluid; fluorescence imaging; human tissue; imaging; imaging modality; liquid; mitochondrial; mucous; nano litre; nanoliter; nanolitre; neuronal; novel; patch clamp; pathogen; pathway; programs; ratiometric; receptor; research study; response; reverse transcriptase PCR; social role; time use; transplant patient; transport inhibitor",Serous Cell Secretion and Cystic Fibrosis Lung Disease,,51817,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",S1,13,13000,
8010035,R01,DK,3,Y,01/18/2010,12/31/2010,PA-07-011,3R01DK052191-11S1,,NIDDK:99533;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"BARON, MARGARET H.;",1880842;,3R01DK052191,01/18/2010,12/31/2010,"21+ years old; Adhesion Molecule; Adhesions; Adhesives; Adult; Appearance; Binding; Binding (Molecular Function); Biology; Blood; Blood (Leukemia); Blood Circulation; Blood Island; Blood Vessels; Blood erythrocyte; Blood normocyte; Blood reticulocyte; Bloodstream; CD106; CD106 Antigens; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell membrane; Cells; Characteristics; Circulation; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cold-Insoluble Globulins; Cytoplasmic Membrane; Development; Diffusely basophilic erythrocyte; Disease; Disorder; Embryo; Embryonic; Erythroblasts; Erythrocyte Transfusion; Erythrocytes; Erythrocytes, Nucleated; Erythrocytic; Erythroid; Erythroid Cells; Erythropoiesis; Event; Extracellular Matrix, Integrins; FN1; FNZ; Fetal Liver; Fibronectin 1; Fibronectins; Funding; Genetic; Gestation; Hematopoietic; Human, Adult; INCAM-110; Inducible Cell Adhesion Molecule 110; Integrins; Intracellular Communication and Signaling; Island; Kupffer Cells; LETS Proteins; Large External Transformation-Sensitive Protein; Leukemias, General; Marrow erythrocyte; Marrow reticulocyte; Mediating; Membrane Proteins; Membrane-Associated Proteins; Mice, Transgenic; Modeling; Molecular; Molecular Interaction; Mother Cells; Normoblasts; Nuclear; Nucleated red blood cell; Nucleated red cell; Nucleus; O element; O2 element; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Oxygen; Pathway interactions; Patients; Plasma Membrane; Play; Polychromatophilic Erythrocyte; Population; Pregnancy; Production; Progenitor Cells; Proteins; Public Health; Receptor Protein; Red Blood Cell Transfusion; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Resolution; Reticulocytes; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Role; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Stable Populations; Staging; Stellate Sinusoidal Macrophage; Stem cells; Surface Proteins; System; System, LOINC Axis 4; Therapeutic; Time; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Work; Yolk Sac; adult human (21+); alpha 2-Surface Binding Glycoprotein; biological signal transduction; blood corpuscles; cell adhesion protein; cell type; disease/disorder; gene product; hESC; human ES cell; human ESC; human embryonic stem cell; in vivo; insight; knock-down; leukemia; liver macrophage; macrophage; migration; nucleated RBCs; pathway; plasmalemma; progenitor; public health medicine (field); public health relevance; receptor; response; social role; tool; vascular; vitelline sac",Erythroid Development in the Mammalian Embryo," Relevance to public health: Characterization of progenitor cell populations and elucidation of the common as well as the distinguishing features of embryonic versus adult erythroid development will be a prerequisite for the directed differentiation of human ES cells, HSCs or hematopoietic progenitors for therapeutic purposes in patients and for the efficient production of pure populations of red blood cells for transfusion. Pathways involved in erythroid development in the embryo may be dysregulated in leukemias and myelodysplastic disorders. The proposed studies should therefore be of broad biomedical signficance.",52191,ZRG1,Special Emphasis Panel,S1,11,99533,
8004338,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK052753-14S1,,NIDDK:64230;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLOTTESVILLE,UNITED STATES,PHARMACOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"STURGILL, THOMAS W;",1867669;,3R01DK052753,01/15/2010,03/31/2010,"1,3 diazine; 1-Phosphatidylinositol 3-Kinase; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Actins; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adipocytes; Adipose Cell; Amino Acids; Anabolism; Antibodies; Antigen-Antibody Complex; Binding; Binding (Molecular Function); Birds of Prey; Cancers; Carbamic acid, monoanhydride with phosphoric acid; Carbamoyl Phosphate; Carbamyl Phosphate; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular Proliferation; Complex; Cyclic AMP; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dictyostelium discoideum; EC 2.7; Enzymes; Event; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fat Cells; G-Protein beta Subunit; GFAC; GTP-Binding Protein beta Subunits; Genetic Translation; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heterotrimeric G Protein Subunit; Homologous Protein; Humulin R; Immune Complex; Immunosuppressants; Immunosuppressive Agents; In element; Incubated; Indium; Initiation Factors; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intracellular Communication and Signaling; KRP protein; KRP(130); Kinases; Ligase; Lipocytes; MODY; Malignant Neoplasms; Malignant Tumor; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Molecular Interaction; Mutate; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; PI-3 Kinase; PI-3K; PI3-Kinase; Pathogenesis; Pathway interactions; Peptide Initiation Factors; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Site; Phosphotransferases; Production; Progress Reports; Protein Binding; Protein Homolog; Protein Kinase; Protein Phosphorylation; ProteinHomolog; Proteins; PtdIns 3-Kinase; Pyrimidine; Pyrimidines; RAFT-1 gene product; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Raptors; Regulatory Element; RegulatoryElement; Reports, Progress; Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Site; SpKRP 85; SpKRP 95; Subcellular Process; Synthetases; T2D; T2DM; Testing; Translation Initiation Factor; Translational Initiation Factor; Translations; Transphosphorylases; Two Hybrid; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adenosine 3'5' monophosphate; adenylcyclase; adult onset diabetes; aminoacid; base; biological signal transduction; biosynthesis; cAMP; cell growth; gene product; glycogen synthase a kinase; human FRAP1 protein; hydroxyalkyl protein kinase; immunosuppressive; insulin resistant; intracellular skeleton; ketosis resistant diabetes; kinase-related protein; kinesin II; mRNA Translation; mTOR; mTOR Inhibitor; mTOR Signaling Pathway; mTOR gene product; mTOR protein; malignancy; mammalian target of rapamycin (mTOR); maturity onset diabetes; neoplasm/cancer; novel; pathway; phosphorylase b kinase kinase; polymerization; prevent; preventing; rapamycin and FKBP12 target 1 protein, human; response; rho; screening; screenings; social role; yeast protein; yeast two hybrid system",mTOR Signaling Pathways,,52753,CSD,Cellular Signaling and Dynamics Study Section,S1,14,64230,
8011282,R01,DK,3,Y,01/20/2010,12/31/2010,,3R01DK052784-13S1,,NIDDK:39628;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MEMPHIS,UNITED STATES,PHYSIOLOGY,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"JOHNSON, LEONARD R.;",1902712;,3R01DK052784,01/20/2010,12/31/2010,"1,4-Butanediamine, N,N'-bis(3-aminopropyl)-; Actinin; Adhesion Plaques; Adhesions; Binding; Binding (Molecular Function); Binding Sites; Cancers; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell-Matrix Adherens Junctions; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Clinical; Combining Site; Complex; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Data; Development; Epithelial Cells; Extracellular Matrix, Integrins; FAK; FAK1; Focal Adhesion Kinase 1; Focal Adhesions; Focal Contacts; Food; Funding; Gastroduodenal Ulcer; Gastrointestinal Tract, Small Intestine; Goals; Grant; Healed; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Injury; Integrins; Intestinal; Intestines; Intestines, Small; Intracellular Communication and Signaling; Malignant Neoplasms; Malignant Tumor; Moab, Clinical Treatment; Modeling; Molecular; Molecular Interaction; Monoclonal Antibodies; Motility; Motility, Cellular; Mucosa; Mucosal Tissue; Mucous Membrane; NIH; National Institutes of Health; National Institutes of Health (U.S.); Normal Cell; Organism-Level Process; Organismal Process; PTK2; PTK2 Protein Tyrosine Kinase 2; Peptic Ulcer; Peptic Ulcer Disease; Phosphorylation; Physiologic Processes; Physiological Processes; Plasma Membrane; Polyamine Compound; Polyamines; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Protein-Tyrosine Kinases, src; Reactive Site; Role; SH2 Domains; Signal Transduction; Signal Transduction Systems; Signaling; Small Intestines; Spermine; Stomach; Subcellular Process; Testing; United States National Institutes of Health; VCL; Vinculin; Vinculin (Caenorhabditis elegans clone pRB9.1 protein moiety reduced); Work; biological signal transduction; bowel; cell motility; endogenous substrate pp120; experiment; experimental research; experimental study; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; gastric; healing; intracellular skeleton; malignancy; migration; neoplasm/cancer; p125(FAK); p125FAK; paxillin; plasmalemma; pp125(FAK); pp125FAK; prevent; preventing; programs; research study; small bowel; social role; src Homology Region 2 Domain; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases",Polyamines and Early GI Mucosal Restitution,,52784,GMPB,Gastrointestinal Mucosal Pathobiology Study Section,S1,13,39628,
8006963,R01,DK,3,Y,01/15/2010,12/31/2010,PA-07-070,3R01DK053113-09S1,,NIDDK:42950;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BATON ROUGE,UNITED STATES,NONE,06,611012324,US,LA,70808,LSU PENNINGTON BIOMEDICAL RESEARCH CTR,"SMITH RICHARDS, BRENDA K;",7002641;,3R01DK053113,01/15/2010,12/31/2010,"Affect; Animal Model; Animal Models and Related Studies; Award; Behavioral; Biological; Body Tissues; Body Weight; CAST/Ei Mouse; Caloric Intake; Calories; Candidate Disease Gene; Candidate Gene; Carbohydrates; Chromosome 17; Chromosome Mapping; Chromosomes, Human, Pair 17; Complex; Congenic Mice; Congenic Strain; Consumption; Control Locus; Custom; Development; Diet; Eating; Eating Behavior; Energy Expenditure; Energy Intake; Energy Metabolism; Exhibits; Expenditure; Fats; Fatty acid glycerol esters; Food Intake; Food Intake Regulation; Funding; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Determinism; Genetics, Gene Mapping; Genotype; Glyoxalase I; Goals; Grant; Heat Production; Inbred Strains Mice; Intake; Lactoyl Glutathione Lyase; Lactoylglutathione Lyase; Lead; Link; Linkage Mapping; Location; Macronutrients; Macronutrients Nutrition; Mammals, Mice; Maps; Metabolism, Carbohydrates/Storage/Polysaccharides; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methylglyoxalase; Mice; Mice, Congenic; Mice, Inbred Strains; Molecular; Murine; Mus; Nutrient; Nutrition, Macronutrients; Obesity; Oxidants; Oxidizing Agents; Pathway interactions; Pattern; Pb element; Phenotype; Physical activity; Population; QTL; Quantitative Trait Loci; R01 Mechanism; R01 Program; RPG; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rest; S-Lactoyl-glutathione methylglyoxal-lyase (isomerizing); Specific qualifier value; Specified; Structure; System; System, LOINC Axis 4; Thermogenesis; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; adiposity; base; caloric dietary content; calorie (nutrition); carbohydrate metabolism; congenic; corpulence; corpulency; corpulentia; density; electron acceptor; energy balance; fat metabolism; gene discovery; gene function; gene interaction; genetic determinant; genetic mapping; glyoxalase; heavy metal Pb; heavy metal lead; lipid metabolism; model organism; obese; obese people; obese person; obese population; pathway; preference; public health relevance; tool; trait",Genetics of Macronutrient Selection and Energy Balance,,53113,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,9,42950,
8009209,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-070,3R01DK053220-11S1,,NIDDK:99963;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOUISVILLE,UNITED STATES,BIOCHEMISTRY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"KLINGE, CAROLYN M.;",1892073;,3R01DK053220,02/01/2010,04/30/2010,"4-Hydroxy-Tamoxifen; 4-chlorophenyl 4-chlorobenzenesulfonate; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; API4; Acetylation; Active Oxygen; Acute; Address; Aging; Anti-Estrogens; Antiestrogens; Aorta; Apoplexy; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Apoptotic; Aquadiol; Area; Assay; Asystole; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Binding Sites; Bioassay; Biogenesis; Biologic Assays; Biological; Biological Assay; Body Tissues; Breast; Breast Cancer Cell; Breast Neoplasms; Breast Tissue; Breast Tumors; CCND1 Protein; CHIP assay; Calorimetry; Cancer of Lung; Cardiac Arrest; Cell Cycle; Cell Cycle Proteins; Cell Death, Programmed; Cell Division Cycle; Cell Division Cycle Proteins; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell-Cycle Regulatory Proteins; Cells; Cellular Proliferation; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; ChIP (chromatin immunoprecipitation); Combining Site; Communication; Consumption; Cyclin D1; Cytochrome Oxidase; Cytochrome c Reductase; Cytochrome-c Oxidase (Complex IV); DNA Maintenance; DNA Polymerase II; DNA Polymerase epsilon; DNA Sequence; DNA Stability; DNA, Mitochondrial; DNA-Dependent DNA Polymerase II; Diaphorase (NADH Dehydrogenase); Dimenformon; Diogyn; Diogynets; EPR-1; Electron Transport Complex IV; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Fluorescence; G1/S-Specific Cyclin D1; Gene Expression; Gene Products, RNA; Gene Proteins; Gene Targeting; Gene Transcription; Generations; Genes; Genetic Transcription; Genital System, Female, Uterus; Genome; Goals; Heart; Heart Arrest; Heating; Histones; Human; Human Breast Cancer Cell; Human, General; Hypothalamic structure; Hypothalamus; IAP4; Investigation; Kidney; Knockout Mice; Lead; Ligands; Liver; Lung; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Malignant Cell; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mammary Cancer; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Man (Taxonomy); Man, Modern; Measures; Mediating; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Mitochondrial DNA; Molecular; Murine; Mus; NADH (Acceptor) Oxidoreductase; NADH Cytochrome c Oxidoreductase; NADH Cytochrome c Reductase; NADH Dehydrogenase; Nerve Degeneration; Neuron Degeneration; Nuclear; Nucleus; Null Mouse; Origin of Life; Output; Ovocyclin; Ovocylin; Oxygen Radicals; PRAD1 Protein; Pathway interactions; Pb element; Play; Pol II; Prevention; Pro-Oxidants; Production; Progynon; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Gene Products; Proteins; Proto-Oncogene Proteins c-bcl-1; Pulmonary Cancer; Pulmonary malignant Neoplasm; RNA; RNA Expression; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Small Interfering; Reactive Oxygen Species; Reactive Site; Recruitment Activity; Regulation; Reporting; Research; Research Specimen; Respiratory Chain; Respiratory System, Lung; Response Elements; Ribonucleic Acid; Role; SERMs; Selective Estrogen Receptor Modulators; Senescence; Small Interfering RNA; Specimen; Steroid Compound; Steroids; Stroke; Targetings, Gene; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Time; Tissues; Titrations; Transcription; Transcription, Genetic; Trauma; Tumor Cell; Tumor Tissue; Urinary System, Kidney; Uterus; Vascular Accident, Brain; antiestrogen; antiestrogenic; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; body system, hepatic; brain attack; c-bcl-1 Proteins; cancer cell; cancer initiation; cancer progression; cdc Proteins; cerebral vascular accident; chlorfenson; chromatin immunoprecipitation; cyclin D; cytochrome c oxidase; estrogen inhibitor; experiment; experimental research; experimental study; functional outcomes; gene product; genetic promoter element; heavy metal Pb; heavy metal lead; hypothalamic; in vivo; insight; lung cancer; mRNA; mammary; mammary tumor; mitochondrial; mitochondrial dysfunction; mtDNA; neoplasm progression; neoplastic; neoplastic cell; neoplastic progression; neural degeneration; neurodegeneration; neuronal degeneration; novel; nuclear respiratory factor; organ system, hepatic; ovex; ovex (pesticide); para-hydroxytamoxifen; pathway; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; protein expression; public health relevance; pulmonary; recruit; renal; research study; respiratory; response; senescent; siRNA; social role; stroke; survivin; tamoxifen metabolite B; transcription factor; tumor progression; tumor xenograft; womb",DNA sequences impact estrogen and antiestrogen activity," Although mitochondrial gene expression depends on nuclear genome function and reciprocally by ""retrograde communication"" mitochondrial activity regulates nuclear gene expression, the mechanisms coordinating these events remain to be clarified. Mitochondrial dysfunction and increased reactive oxygen species mediate the pathophysiologic mechanisms of aging, acute neurodegeneration caused by trauma, stroke, or cardiac arrest; and cancer initiation and tumor progression. The impact of steroids on mitochondrial function ""is a new and novel area of investigation"" and the proposed study seeks to delineate a new biological pathway of estrogen and antiestrogens/SERMs in regulating nuclear respiratory factor-1 (NRF-1) and its downstream targets in mitochondrial activity.",53220,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S1,11,99963,
8010061,R01,DK,3,Y,01/15/2010,09/30/2010,,3R01DK053528-12S1,,NIDDK:34000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DAVIS,UNITED STATES,BIOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"PRIVALSKY, MARTIN L.;",1863721;,3R01DK053528,01/15/2010,09/30/2010,"Address; Autoregulation; Binding; Binding (Molecular Function); Biological; Biological Function; Biological Process; Body Tissues; Boxing; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cellular Proliferation; Chemotherapy-Hormones/Steroids; Complex; Defect; Disease; Disorder; EC 2.7; Endocrine; Endocrine Diseases; Endocrine Diseases and Manifestations; Endocrine Gland Secretion; Endocrine System Diseases; Estrogen Receptors; Exhibits; Gene Down-Regulation; Gene Targeting; Gene Transcription; Genetic Transcription; Goals; Homeostasis; Hormones; Human; Human, General; Individual; Intracellular Communication and Signaling; Investigation; Investigators; Isoforms; KIAA1047; Kinases; Knowledge; Lead; Lesion; Ligands; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Modeling; Molecular; Molecular Interaction; N-CoR; N-CoR1; N-terminal; NCOR1; NCOR1 protein, human; NH2-terminal; Normal Cell; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Corepressor; Nuclear Receptors; Pb element; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Physiology; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Phosphorylation; Proteins; RNA Expression; RNA Splicing; RNA, Messenger; Receptor Protein; Recruitment Activity; Repression; Reproduction; Research; Research Personnel; Researchers; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Splicing; Steroid Compound; Steroids; TRAC1; Targetings, Gene; Therapeutic Hormone; Thyroid Gland Hormone; Thyroid Hormone Receptor; Thyroid Hormone Receptor beta 1; Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1; Thyroid Hormones; Tissues; Touch; Touch sensation; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Transphosphorylases; Variant; Variation; adipocyte development; adipocyte differentiation; biological signal transduction; cofactor; disease/disorder; endocrine disorder; experiment; experimental research; experimental study; gene product; gene repression; hCIT529I10; hN-CoR; heavy metal Pb; heavy metal lead; human NCOR1 protein; improved; mRNA; neoplastic; programs; receptor; receptor function; recruit; research study; response; social role; transcription factor",Role of cofactors in nuclear hormone receptor function.,,53528,ZRG1,Special Emphasis Panel,S1,12,34000,
8011405,R01,DK,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01DK053839-12S1,,NIDDK:101270;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,GENETICS,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KAESTNER, KLAUS H.;",2106137;,3R01DK053839,01/20/2010,12/31/2010,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; A Mouse; APC - Adenomatous Polyposis Coli; Ablation; Abscission; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Adenomatous Polyps; Adult; After Care; After-Treatment; Aftercare; Alleles; Allelic Loss; Allelomorphs; Anterior; Anti-Oncogenes; Antioncogenes; Archenteron; Autoregulation; Azoxymethane; BUdR; Biology; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Cancer Biology; Cancer Causing Agents; Cancer Induction; Cancer of the Gastrointestinal Tract; Cancers; Candidate Disease Gene; Candidate Gene; Carcinogens; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Oncogene; Cellular Proliferation; Cessation of life; Chromosomal Instability; Chromosome Instability; Colorectal Cancer; DNA; Death; Deoxyribonucleic Acid; Detection; Development; Diazene, dimethyl-, 1-oxide; ES cell; Emerogenes; Endoderm; Epithelium; Epithelium, Intestinal; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Excision; Extirpation; Familial Adenomatous Polyposis Syndrome; Future; Gastrocoele; Gastrointestinal Cancer; Gene Targeting; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genetics-Mutagenesis; Genome; Genotoxins; Goals; Health; Hereditary Adenomatous Polyposis Coli; High Throughput Assay; Histologic; Histologically; Homeo Boxes; Homeobox; Homeostasis; Human; Human, Adult; Human, General; Incidence; Insertional Mutagenesis; Intestinal; Intestines; Laboratories; Lead; Loss of Heterozygosity; Malignant Gastrointestinal Neoplasm; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of gastrointestinal tract; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Biology, Mutagenesis; Mother Cells; Murine; Mus; Mutagenesis; Mutagenesis, Insertional; Mutagens; Mutate; Mutation; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogens; Pathway interactions; Pattern; Pb element; Physiological Homeostasis; Play; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Polyps; Predisposition; Primitive Guts; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proto-Oncogenes; Regulatory Pathway; Removal; Reporting; Retrotransposition; Retrotransposon; Role; Sampling; Second-Site Suppressor Genes; Signal Pathway; Staging; Stem cells; Structure of intestinal epithelium; Suppressor Genes; Surgical Removal; Susceptibility; TAM; Tamoxifen; Targetings, Gene; Techniques; Testing; Therapeutic; Transgenes; Transgenic Mice; Tumor Burden; Tumor Load; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; United States; Uridine, 5-bromo-2'-deoxy-; adult human (21+); bowel; c-ONC; carcinogenesis; cell type; embryonic stem cell; experiment; experimental research; experimental study; familial adenomatous polyposis; familial polyposis; fetal; gain of function; gastrointestinal; gene cloning; genome mutation; genotoxic agent; heavy metal Pb; heavy metal lead; high throughput screening; in vivo; innovate; innovation; innovative; intestinal crypt; intestinal epithelium; laser capture microdissection; loss of function; malignancy; neoplasm/cancer; new diagnostics; next generation diagnostics; novel; novel diagnostics; oncosuppressor gene; pathway; polypoid adenoma; protooncogene; research study; resection; social role; stem cell of embryonic origin; tool; transcription factor; tumor; tumor suppressor; tumorigenesis; villin",Regulatory cascades in gastrointestinal proliferation,,53839,ZRG1,Special Emphasis Panel,S1,12,101270,
8011274,R01,DK,3,Y,01/25/2010,01/24/2011,PA-07-070,3R01DK054111-12S1,,NIDDK:99999;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WEST LAFAYETTE,UNITED STATES,NUTRITION,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"FLEET, JAMES C;",1862470;,3R01DK054111,01/25/2010,01/24/2011,"1,25-Dihydroxycholecalciferol Receptors; 1,25-Dihydroxyvitamin D3 Receptors; 25-HCC-Binding Protein; 25-Hydroxycholecalciferol-Binding Protein; 25-Hydroxyvitamin D-Binding Protein; Absorption; Activation, Gene; Age; Aged 65 and Over; Aging; Androgen Receptor; Animals; Apical; Attention; Autoregulation; Blood Coagulation Factor IV; Bone; Bone Diseases; Bone and Bones; Bone structure of spine; Bones and Bone Tissue; Ca++ element; Calciferol-Binding Protein; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium, Dietary; Cecum; Cell Communication and Signaling; Cell Signaling; Cells; Change of Life, Female; Chaperone; Chemotherapy-Hormones/Steroids; Cholecalciferol Receptors; Coagulation Factor IV; Colon; Complex; Data; Development; Dietary Calcium; Diffusion; EC 2.7; Elderly; Elderly, over 65; Endocrine Gland Secretion; Enterocytes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Evolution; Factor IV; Foundations; Fracture; Gastrointestinal Tract, Small Intestine; Gc Globulin; Gene Activation; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Glucocorticoids; Goals; Group-Specific Component Globulin; Hip Fractures; Homeostasis; Hormones; Human; Human, General; Intestinal; Intestines; Intestines, Small; Intracellular Communication and Signaling; Ion Channels, Calcium; Kidney; Kinases; Kinetic; Kinetics; Knockout Mice; Life; Ligand Binding; Ligands; Location; Maintenance; Maintenances; Malabsorption Syndromes; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Menopause; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Molecular Chaperones; Movement; Murine; Mus; Null Mouse; Nutrient; Osteoporosis; Osteoporosis prevention; Peripheral; Phase; Phenotype; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Physiology; Play; Position; Positioning Attribute; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Prevention; Prevention strategy; Preventive strategy; Process; Process of absorption; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Proteins; RNA Expression; RXR alpha Receptor; RXRA; Receptor Protein; Receptors, 1,25-Dihydroxyvitamin D 3; Receptors, Calcitriol; Receptors, Calcium Channel Blocker; Regulation; Relative Risks; Research; Resistance; Retinoic Acid Receptor RXR-Alpha; Retinoid X Receptor A; Retinoid X Receptor alpha; Risk; Risks, Relative; Role; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Small Intestines; Stress; Targetings, Gene; Testing; Therapeutic Estrogen; Therapeutic Glucocorticoid; Therapeutic Hormone; Transcalciferin; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Transphosphorylases; Up-Regulation; Urinary System, Kidney; VDCC; VDR; VIT D; Vertebrae; Vertebral; Vitamin D; Vitamin D 3 Receptors; Vitamin D Receptors; Vitamin D-Binding Globulin; Vitamin D-Binding Protein; Vitamin D3 Receptor; Voltage-Dependent Calcium Channels; Woman; Work; absorption; advanced age; aged; apical membrane; base; biological signal transduction; body movement; bone; bone disorder; bone fracture; bone health; bone mass; bowel; calcium absorption; calcium intake; calcium metabolism; elders; fundamental research; gastrointestinal absorption disorder; gene product; geriatric; ileum; in vivo; interest; intestinal malabsorption; language translation; late life; later life; malabsorption; member; menopausal; older adult; older person; physiologic model; post-menopausal; postmenopausal; pre-clinical; preclinical; prevent; preventing; public health relevance; rapid growth; receptor; receptor expression; receptor function; renal; resistant; response; senescent; senior citizen; small bowel; social role; spine bone structure; steroid hormone receptor; transgenic; translational study; uptake",Intestinal Calcium Absorption: Molecular Mechanism," Project Narrative Dietary calcium is essential for bone health and the prevention of the bone disease osteoporosis. Unfortunately, the ability of the intestine to absorb dietary calcium is reduced with aging and the menopause. Vitamin D is the major regulator of intestinal calcium absorption but many factors may impair vitamin D action. We will conduct mechanistic and translational studies to examine how vitamin D influences intestinal calcium absorption. Our focus will be on events that occur through a protein that bindings vitamin D, the vitamin D receptor. This work will lay the foundation for developing osteoporosis prevention strategies that maximize vitamin D action in the intestine and optimize the absorption of dietary calcium.",54111,ZRG1,Special Emphasis Panel,S1,12,99999,
7992517,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-070,3R01DK054317-10S1,,NIDDK:93247;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PISCATAWAY,UNITED STATES,PHARMACOLOGY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"LOBEL, PETER ;",1871774;,3R01DK054317,02/01/2010,04/30/2010,"Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Anatomic Abnormality; Anatomical Abnormality; Cancers; Causality; Cell Fractionation; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Clinical; Communities; Congenital or Acquired Anatomic Abnormality; Congenital or Acquired Anatomical Abnormality; Death; Defect; Deformity; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Enzymes; Etiology; Family; Future; GM2 Gangliosidosis, Type I; Gangliosidosis G(M2), Type I; Gene Proteins; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Counseling; Genetic Diseases; Genetic defect; Genetics, Human; Goals; Hereditary Disease; Hexosaminidase A Deficiency Disease; Human; Human Genetics; Human, General; Hydrolysis; Individual; Integral Membrane Protein; Intrinsic Membrane Protein; Investigation; Linkage Analysis; Lysosomes; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Membrane; Mental Retardation; Methods; Molecular; Molecular Disease; Mutation; Organelles; Photometry/Spectrum Analysis, Mass; Prevalence; Primary Senile Degenerative Dementia; Protein Gene Products; Proteins; Proteome; Proteomics; Research; Research Resources; Resources; Role; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; System; System, LOINC Axis 4; Tay-Sachs Disease; Transmembrane Protein; base; comparative; dementia of the Alzheimer type; disease causation; disease etiology; disease-causing mutation; disease/disorder; disease/disorder etiology; disorder etiology; family based linkage study; functional genomics; gene product; genetic disorder; genetic linkage analyses; genetic linkage analysis; genome mutation; hereditary disorder; hexosaminidase A deficiency; human disease; linkage analyses; lysosomal proteins; macromolecule; malignancy; membrane structure; neoplasm/cancer; premature; primary degenerative dementia; senile dementia of the Alzheimer type; social role; subcellular fractionation",Lysosomal Enzymes and Associated Human Genetic Diseases,,54317,ZRG1,Special Emphasis Panel,S1,10,93247,
7991693,R01,DK,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01DK054407-12S1,,NIDDK:99452;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"WEISZ, ORA A;",1930889;,3R01DK054407,01/01/2010,12/31/2010,"1,2-Diacylglycerol Kinase; ADP-Ribosylation Factors; ARF Protein Cofactor; ATP[{..}]1,2-diacylglycerol 3-phosphotransferase; Abbreviations; Acute Kidney Failure; Adaptor Protein; Adaptor Signaling Protein; Address; Apical; Binding; Binding (Molecular Function); Biochemical; Blood Circulation; Blood Pressure, High; Bloodstream; CBP-30; CBP-35; CBP35; CURL; Canine Species; Canis familiaris; Carbohydrate-Binding Protein 35; Carbohydrates; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Circulation; Compartment of the Uncoupling Receptors and Ligands; Cues; Cytoplasmic Membrane; DAG Kinase; Data; Dextrin 6-alpha-D-glucanohydrolase; Diacylglycerol Kinase; Diglyceride Kinase; Disease; Disorder; Dogs; EC 2.7; Early Endosome; Endosomes; Epithelial; Epithelial Cells; Epsilon-Binding Protein; Face; G protein, vesicular stomatitis; G protein, vesicular stomatitis virus; GDI Proteins; GDIs; GDP Dissociation Inhibitors; GPI; Galectin 3; Gene Products, RNA; Gly-PtdIns; Glycans; Glycolipids; Glycosyl-Phosphatidylinositol; Glycosylated Phosphatidylinositols; Glycosylphosphatidylinositols; Goals; Golgi; Golgi Apparatus; Golgi Complex; Granulocyte/Pollen-Binding Protein; Guanine Nucleotide Dissociation Inhibitors; HL-29; HRP; Hemagglutinin; Horseradish Peroxidase; Human Growth Hormone; Hydrogen Oxide; Hypertension; IgA; IgE Binding Protein; IgEBP; Immunoglobulin A; Individual; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Ion Transport; Ions; Isomaltase; Kidney; Kidney Cancer; Kidney Carcinoma; Kidney Failure, Acute; Kidney Insufficiency, Acute; Kinases; L-29 Lectin; L-31; L-34; L30 Lectin; LGALS3; Laboratories; Lactase Phlorizin Hydrolase; Lecithinase D; Lectin; Life; Lipid Rafts, Cell Membrane; Lipids; Mac-2 Antigen; Macrophage-2 Antigen; Maintenance; Maintenances; Mammals, Dogs; Mediating; Membrane; Membrane Microdomains; Membrane Proteins; Membrane-Associated Proteins; Molecular; Molecular Interaction; Nerve Growth Factor Receptors; Neurotrophic Factor Receptor; Oligo-1,6-Glucosidase; PIP2; Pathway interactions; Peptides; Phosphatidyl Inositol; Phosphatidylcholine Phosphohydrolase; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphoinositides; Phospholipase D; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphotransferases; Physiologic; Physiological; Plasma Membrane; Play; Poly-Ig Receptor; Polymeric Immunoglobulin Receptors; Polysaccharides; Population; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Proteins; Proteomics; PtIns 4,5-P2; PtdIns; PtdInsP2; RNA; RNA, Non-Polyadenylated; RNA, Small Interfering; Racial Segregation; Receptor, Polyimmunoglobulin; Receptor, Polymeric Ig; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Receptosomes; Recycling; Regulation; Regulatory Protein; Renal Cancer; Renal Cell; Renal Failure, Acute; Renal Insufficiency, Acute; Renal carcinoma; Renal function; Reporting; Research; Ribonucleic Acid; Role; Route; Siderophilin; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Somatotropin (Human); Somatropin; Somatropin (Human); Sorting - Cell Movement; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Staging; Stimulus; Subcellular Process; Sucrase; Sucrose alpha-D-Glucohydrolase; Surface; Surface Proteins; System; System, LOINC Axis 4; TGN; Testing; Transferrin; Transferrin Receptor; Transphosphorylases; Triticum Vulgare Lectins; Urinary System, Kidney; Urinary System, Urine; Urine; VSV; VSV-TG protein; VSVG protein; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vesicular Stomatitis Virus; Vesicular stomatitis Indiana virus; Water; Wheat Germ Agglutinins; Wheat Germ Lectins; biological signal transduction; canine; cell imaging; cellular imaging; cohort; combat; design; designing; disease/disorder; domestic dog; endolyn; facial; gene product; genetic regulatory protein; hGH; hGH (Human Growth Hormone); hyperpiesia; hyperpiesis; hypertensive disease; in vitro Assay; kidney cell; kidney function; lipid raft; lipophosphodiesterase II; membrane structure; p75; p75 transcription factor; pathway; phosphatidylcholine phosphatidohydrolase; plasmalemma; polarized cell; regulatory gene product; renal; response; segregation; siRNA; sialomucin; sialomucins; site targeted delivery; social role; sorting; targeted delivery; trafficking; trans-Golgi Network; transcriptional coactivator p75; vesicular stomatitis virus G protein",Regulation of Apical Traffic in Renal Epithelial Cells,,54407,CMBK,Cellular and Molecular Biology of the Kidney Study Section,S1,12,99452,
7996512,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK054479-11S1,,NIDDK:92845;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WORCESTER,UNITED STATES,OTHER BASIC SCIENCES,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"CORVERA, SILVIA ;",1867622;,3R01DK054479,01/15/2010,03/31/2010,"1-Phosphatidylinositol 3-Kinase; 3T3-L1 Cells; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adipocytes; Adipose Cell; Affinity; Amino Acid Motifs; Binding; Binding (Molecular Function); Biochemical; Biological; Bone-Derived Transforming Growth Factor; C elegans; C.elegans; CURL; Caenorhabditis elegans; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Clathrin; Compartment of the Uncoupling Receptors and Ligands; Cultured Cells; Cytoplasmic Membrane; Defect; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; EC 2.7; EGF; EGF gene; ENDOFIN protein, human; Early Endosome; Endocytosis; Endocytosis Inhibition; Endosomes; Event; Fat Cells; Funding; GLUT4; GLUT4 gene; GeneHomolog; Genome, Human; Goals; Granulocyte/Pollen-Binding Protein; Homolog; Homologous Gene; Homologue; Human Genome; Humulin R; Hybrids; INSR; Image; Impairment; In Transferrin; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Investigators; Kinases; Kinetic; Kinetics; Laboratories; Life; Lipocytes; MADH-Interacting Protein; MADHIP protein, human; MODY; Mammalian Cell; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Membrane Protein Traffic; Membrane Traffic; Methods and Techniques; Methods, Other; Microscopy; Milk Growth Factor; Molecular; Molecular Interaction; Mothers Against Decapentaplegic Homolog Interacting Protein; Mothers Against Decapentaplegic, Drosophila Homolog Interacting Protein, Receptor Activation Anchor; NIDDM; NSP protease, human; Names; Nature; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novel Serine Protease; Novolin R; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Plasma Membrane; Platelet Transforming Growth Factor; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Motifs; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; Proteomics; PtdIns; PtdIns 3-Kinase; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Receptor Activation Anchor Protein; Receptosomes; Recycling; Reporting; Research Personnel; Researchers; Role; SARA Protein; SARA protein, human; SMAD Anchor for Receptor Activation; Sequence-Specific Posttranscriptional Gene Silencing; Serine Kinase; Serine-Threonine Kinases; Siderophilin; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Smad anchor for receptor activation, human; Small Interfering RNA; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; System; System, LOINC Axis 4; T2D; T2DM; TGF B; TGF-beta; TGFbeta; Techniques; Testing; Threonine Kinase; Time; Transferrin; Transferrin Receptor; Transforming Growth Factor beta; Transphosphorylases; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; URG; VESCL; Vesicle; Work; ZFYVE16 protein, human; adult onset diabetes; base; biological signal transduction; cancer type; coated pit; disease/disorder; gene product; glucose transport; glucose uptake; hSARA; human MADHIP protein; imaging; in vivo; insulin signaling; ketosis resistant diabetes; maturity onset diabetes; new technology; novel; pathway; plasmalemma; protein function; receptor recycling; siRNA; social role; tool; trafficking; transcription factor; uptake; zinc finger, FYVE domain containing 16 protein, human",PI-3 kinase effectors in insulin-responsive systems,,54479,MCE,Molecular and Cellular Endocrinology Study Section,S1,11,92845,
7982449,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK054508-12A1S1,,NIDDK:99000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,BIOCHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LIN, SHUO ;",1864456;,3R01DK054508,01/07/2010,12/31/2010,"ATGN; Angioblast; Animal Model; Animal Models and Related Studies; Anterior; Antigens; Arts; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Blood; Blood Precursor Cell; Blood Vessels; Body Tissues; Brachydanio rerio; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Chimera Protein; Chimeric Proteins; Comprehension; Coupled; DNA Binding; DNA Binding Interaction; Danio rerio; Data; Development; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endothelial Cells; Enhancers; Expression Profiling; Expression Signature; Fishes; Funding; Fusion Protein; Gene Expression; Gene Targeting; GeneHomolog; Genes; Genetic; Genetic analyses; Genomics; Goals; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Homolog; Homologous Gene; Homologue; Human; Human, General; Intracellular Communication and Signaling; Laboratories; Lateral Mesoderm; MYB; MYB gene; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mesoderm; Mesoderm Cell; Mesodermal Cell; Messenger RNA; Mice; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Murine; Mus; Myelogenous; Myeloid; Myeloid Cells; Pathogenesis; Pattern; Physiology; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Proto-Oncogene Products c-myb; Proto-Oncogene Proteins c-myb; RNA, Messenger; Reticuloendothelial System, Blood; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Targetings, Gene; Technology; Testing; Therapeutic; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Transcript; Transgenic Organisms; Up-Regulation; Up-Regulation (Physiology); Upregulation; V-Myb Myeloblastosis Viral Oncogene Homolog; Vascular Diseases; Vascular Disorder; Zebra Danio; Zebra Fish; Zebrafish; biological signal transduction; blood vessel disorder; c myb; c-Myb; c-myb Gene; c-myb Proteins; c-myb Proto-Oncogenes; cis acting element; design; designing; experiment; experimental research; experimental study; genetic analysis; genome-wide; hESC; human ES cell; human ESC; human disease; human embryonic stem cell; immunogen; intervention development; mRNA; migration; model organism; molecuar profile; molecular signature; myb Proto-Oncogene Proteins; novel; novel therapeutic intervention; overexpression; progenitor; public health relevance; research study; social role; therapy development; trans acting factor (genetic); transcription factor; transgenic; treatment development; vascular; vasculogenesis",Genetic Analysis of Hematopoietic Development," NARRATIVE  Zebrafish is a popular model organism for studying development, physiology and human diseases. We use state of the art technologies to identify and characterize essential new genes required for the formation of blood stem cells and vascular progenitors in zebrafish. Since these genes are highly conserved between fish and human our studies will provide valuable information for understanding human hematopoietic and vascular diseases and assisting design of novel therapeutic approaches.",54508,ZRG1,Special Emphasis Panel,A1S1,12,99000,
8010070,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK054733-09S1,,NIDDK:132537;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MINNEAPOLIS,UNITED STATES,PHARMACOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"WEI, LI-NA ;",1866137;,3R01DK054733,01/15/2010,12/31/2010,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 9-cis-Retinoic Acid Receptor; APOE [{C0003595}]; ATRA; Acetylation; Address; Affect; All-trans retinoic acid; Apo-E; ApoE; Apolipoprotein E; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Blood Plasma; CCND1 Protein; CHIP assay; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle Progression; Cell Nucleus; Cell Signaling; ChIP (chromatin immunoprecipitation); Chromatin; Complex; Cyclin D1; Cyclins; DNA; DNA Binding; DNA Binding Interaction; Deoxyribonucleic Acid; Detection; Dimerization; Endocrine system; Endocrine system (all sites); Endocrine/Metabolic Organ System; Event; Family; Funding; G1/S-Specific Cyclin D1; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Goals; Histones; Hormonal; Hormonal System; In Vitro; Intracellular Communication and Signaling; Kinetic; Kinetics; Ligands; Metabolic/Endocrine Body System; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methylation; Modification; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; NRIP1; NRIP1 Protein; NRIP1 protein, human; Nature; Nuclear; Nuclear Receptor Interacting Protein 1; Nuclear Receptors; Nucleic Acid Regulatory Sequences; Nucleosomes; Nucleus; Orphan; PRAD1 Protein; Pathway interactions; Phosphorylation; Plasma; Play; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Dimerization; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteomics; Proto-Oncogene Proteins c-bcl-1; RIP140; RIP140 Protein; RNA Expression; RXR; RXR Protein; Receptor Interacting Protein 140; Receptor Interacting Protein, 140 kDa; Receptor Protein; Recruitment Activity; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reporting; Reticuloendothelial System, Serum, Plasma; Retinoic Acid; Retinoic Acid Receptor RXR; Retinoid X Receptors; Role; Serum, Plasma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Surface; System; System, LOINC Axis 4; TR2 receptor; Targetings, Gene; Testing; Trans Vitamin A Acid; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Tretinoin; Tretinoinum; Up-Regulation; Vitamin A; Vitamin A Acid; all-trans-Retinoic Acid; all-trans-Vitamin A acid; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; cell type; chromatin immunoprecipitation; chromatin remodeling; conformation; conformational state; cyclin D; endocrine gland/system; fat metabolism; genetic regulatory element; histone modification; human NRIP1 protein; in vivo; lipid metabolism; novel; orphan nuclear receptor NR2C1; orphan nuclear receptor TR2; orphan receptor, TR2; pathway; receptor; recruit; retinol; social role; trans-Retinoic Acid",TR2 nuclear receptor in vitamin A signaling,,54733,ZRG1,Special Emphasis Panel,S1,9,132537,
8011602,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK055003-11S1,,NIDDK:51709;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"ROZENGURT, JUAN ENRIQUE;",6778638;,3R01DK055003,02/01/2010,01/31/2011,"5-oxoPro-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-MetNH2; 70-kDa Ribosomal Protein S6 Kinases; Agonist; Alimentary Canal; Applications Grants; Binding; Binding (Molecular Function); Biological Function; Biological Process; Bombesin; Bombesin 14; C protein; CBP protein (citrate-binding); Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cancers; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Proliferation Regulation; Cell Signaling; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Proliferation; Chemicals; Chronic; Development; Digestive Tract; Disease; Disorder; Distal; EC 2.7; EC 2.7.2-; ERK MAP Kinases; Epithelial Cells; Epithelium; Event; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Family; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; GI Tract; GPCR Signaling; Gastrin releasing peptide; Gastrin-Releasing Peptide (1-27); Gastrointestinal Hormone Receptors; Gastrointestinal Tract; Gastrointestinal tract structure; Generalized Growth; Goals; Grant Proposals; Grants, Applications; Growth; In Vitro; In element; Indium; Inflammatory; Intestinal; Intestinal Hormone Receptors; Intestines; Intracellular Communication and Signaling; Investigation; Kinases; Laboratories; MAP kinase; MAPK; Malignant Neoplasms; Malignant Tumor; Mediating; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mitogenesis; Modeling; Molecular Interaction; Molecular Mechanisms of Action; Oncogenesis; PKC; PKD protein; Pathogenesis; Pathway interactions; Peptide Signal Sequences; Peptides; Phase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphotransferases; Play; Positive Control of Cell Proliferation; Process; Protein Kinase C; Protein Phosphorylation; Proteins; Public Health; RAFT-1 gene product; Rapamune; Rapamycin; Receptor Activation; Receptors, Gastrointestinal Hormone; Receptors, Gastrointestinal Peptides; Regulation; Ribosomal Protein S6 Kinases, 70-kDa; Role; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Sirolimus; Stimulation of Cell Proliferation; Subcellular Process; Testing; Therapeutic Intervention; Threonine/Tyrosine Protein Kinase; Tissue Growth; Transgenic Mice; Transgenic Organisms; Transphosphorylases; alimentary tract; biological signal transduction; biological systems; bowel; cell growth; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; digestive canal; disease/disorder; experience; extracellular signal related kinase; gastrointestinal; gene product; in vivo; interest; intervention therapy; mTOR gene product; mTOR protein; malignancy; mammalian bombesin; mammalian target of rapamycin (mTOR); migration; mouse model; mutant; neoplasm/cancer; novel; ontogeny; p70 S6 Kinase; p70s6k; pathway; protein kinase D; protein signal sequence; public health medicine (field); response; social role; transgenic; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; tumorigenesis",Gastrointestinal Peptide Signaling through PKC/PKD,,55003,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,S1,11,51709,
8004390,R01,DK,3,Y,01/15/2010,12/30/2010,PA-07-070,3R01DK055524-11A2S1,,NIDDK:150899;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLESTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"LUTTRELL, LOUIS M;",1871569;,3R01DK055524,01/15/2010,12/30/2010,"ANG-(1-8)Octapeptide; ATP-protein phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Affect; Agonist; AngII; Angiotensin AT1a Receptor; Angiotensin II; Angiotensin II Type 1a Receptor; Angiotensin Type 1a Receptor; Angiotensin-(1-8) Octapeptide; Anthelone U; Arrestins; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Biological; Blood Vessels; Bone; Bone and Bones; Bones and Bone Tissue; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Characteristics; Complex; Cytoplasmic Membrane; Cytosol; Data; Development; Disease Progression; Drugs; EC 2.7; EC 2.7.2-; EGF; EGFR; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; ERK 2; Endosomes; Environment; Enzymes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor-Urogastrone; Extracellular Signal-Regulated Kinase 2; Extracellular Signal-Regulated Kinases; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-Proteins; G-substrate; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Transcription; Genetic Transcription; Genital System, Male, Prostate; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HEK3; HER1; Heart; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Human Prostate; Human Prostate Gland; Human Urinary Gastric Inhibitor; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messengers; Isoforms; Kidney; Kinases; Laboratories; Leiomyocyte; Ligands; MAP Kinase 1; MAP Kinase 2; MAP kinase; MAPK; MAPK1; MAPK1 Mitogen-Activated Protein Kinase; MAPK2 Mitogen-Activated Protein Kinase; METBL; Mediating; Medication; Membrane; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Mitogen Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 2; Mitogen-Activated Protein Kinases; Modeling; Molecular Interaction; Myocytes, Smooth Muscle; Neoplasms; Nucleus; Organ System; P42MAPK; PRKM1; PTK; PTK Receptors; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Plasma Membrane; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prostate; Prostate Gland; Prostatic Gland; Protein Isoforms; Protein Kinase; Protein Modification; Protein Modification, Post-Translational; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein phosphatase; Protein-Tyrosine Kinases, src; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteomics; RNA Expression; RNA, Small Interfering; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptosomes; Regulation; Research; Role; Scaffolding Protein; Second Messenger Systems; Second Messengers; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spatial Distribution; Structure; Subcellular Process; System; System, LOINC Axis 4; Testing; Time; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Transducers; Transforming Growth Factor alpha Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Transmission; Transphosphorylases; Tumors; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Urinary System, Kidney; Urogastrone; Work; atheromatosis; atherosclerotic vascular disease; beta-Urogastrone; biological signal transduction; body system; bone; c-erbB-1; c-erbB-1 Protein; calcium flux; calcium mobilization; cell growth; cerebellum protein substrate for cGMP dependent protein kinase; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; hydroxyaryl protein kinase; inhibitor; inhibitor/antagonist; insight; membrane structure; mutant; neoplasia; neoplastic growth; new therapeutics; next generation therapeutics; novel; novel therapeutics; p42 MAP Kinase; p42 MAPK; p42(Mapk) Kinase; p42(Mitogen-Activated Protein Kinase); pathway; phosphorylase b kinase kinase; plasmalemma; programs; protein G; protein activation; protein expression; proto-oncogene protein c-erbB-1; public health relevance; receptor; receptor binding; receptor function; release of sequestered calcium ion into cytoplasm; renal; research study; response; scaffold; scaffolding; second messenger; shRNA; short hairpin RNA; siRNA; small hairpin RNA; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; transmission process; tyrosyl protein kinase; vascular",Tyrosine Kinases in G Protein Mediated Signaling," Contrary to the traditional view that G protein-coupled receptors (GPCRs) only signal by activating heterotrimeric G proteins, recent research has shown that they also transmit G protein-independent signals that are initiated by binding to adapter or scaffold proteins. This project focuses on the role of arrestins in angiotensin AT1A receptor signaling. Arrestins bind to activated GPCRs, 'uncoupling' them from G proteins, while at the same time promoting the assembly of 'signalsomes' that affect protein phosphorylation and gene transcription. Our research will define the factors that control the assembly and function of the AT1A receptor- arrestin signalsome and determine how G protein-dependent and arrestin-dependent signals are integrated. These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties.",55524,MIST,Molecular and Integrative Signal Transduction Study Section,A2S1,11,150899,
8015388,R01,DK,3,,02/01/2009,01/31/2010,,3R01DK055865-08S3,,NIDDK:80240;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAPEL HILL,UNITED STATES,NUTRITION,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"ZEISEL, STEVEN H;",7357157;,3R01DK055865,09/01/2000,01/31/2012,"2-Hydroxy-N,N,N-trimethylethanaminium; 5,6,7,8-Tetrahydrofolate[{..}]NADP+ oxidoreductase; Address; Affect; Alleles; Allelomorphs; Anabolism; Betaine; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cephalins; Choline; Choline Deficiency; Choline Glycerophospholipids; Choline Phosphoglycerides; Choline dehydrogenase; Clinical Research; Clinical Study; Cross-Product Ratio; Cytoplasmic Membrane; DHFR; Developmental Defects, Neural Tube; Diet; Dihydrofolate Dehydrogenase; Dihydrofolate Reductase; Dysfunction; EC 1.5.1.3; EC 2.1.1; Enzymes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethanolamine Phosphoglycerides; Ethanolamineglycerophospholipids; Fatty Liver; Female; Folate Metabolism; Folic Acid Metabolosm; Folic Acid Reductase; Functional disorder; Funding; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Glycine Betaine; Heterogeneity, Population; Human; Human, General; Individual; Institute of Medicine; Institute of Medicine (U.S.); Intake; Intermediary Metabolism; Intracellular Communication and Signaling; Lecithin; Lipid Trafficking; Liver Steatosis; Lycine; METBL; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Methanaminium, 1-carboxy-N,N,N-trimethyl-, inner salt; Methyltransferase; Methyltransferase Gene; Muscle; Muscle Tissue; NAS/IOM; Nerve Impulse Transmission; Nerve Transmission; Neural Tube Defects; Neuronal Transmission; Nutrient; Nutritional Requirements; O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamine; Odds Ratio; Organ; Oxyneurine; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Physiopathology; Plasma Membrane; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Population Heterogeneity; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Pre-Menopause; Pre-menopausal Period; Predisposition; Premenopausal; Premenopausal Period; Premenopause; Prevalence; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Recommendation; Recruitment Activity; Relative Odds; Resistance; Risk; Risk Ratio; S-adenosylmethionine phosphatidylethanolamine N-methyltransferase; SNP; SNPs; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Source; Susceptibility; Tetrahydrofolate Dehydrogenase; Therapeutic Estrogen; Variant; Variation; Variation (Genetics); Woman; allelic variant; base; betaine compound; biological signal transduction; biosynthesis; carbene; choline deficient diet; cholinergic; dietary requirement; diverse populations; experiment; experimental research; experimental study; feeding; folic acid metabolism; gain of function; genetic promoter element; hepatic steatosis; heterogeneous population; interest; lipid transport; loss of function; membrane synthesis; men; men's; methyl group; methylase; methylene; methylene radical; neurotransmission; nutrient requirement; oxidation; pathophysiology; phosphatidylethanolamine; phosphatidylethanolamine methyltransferase; phosphatidylethanolamine-phosphatidylcholine N-methyltransferase; plasmalemma; polymorphism; post-menopausal; postmenopausal; pre-menopausal; prevent; preventing; recruit; research study; resistant; transmethylase",Human Requirements for the Nutrient Choline,,55865,ZRG1,Special Emphasis Panel,S3,8,80240,
8012886,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK056733-08S2,,NIDDK:99999;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","NYBERG, SCOTT L;",1946779;,3R01DK056733,02/01/2010,01/31/2011,"Acute; Acute Liver Failure; Address; Adverse effects; Affect; Albumins; Ammonia; Animals; Artificial Liver; Bioartificial Liver; Biochemical; Biomedical Engineering; Canine Species; Canis familiaris; Cells; Cerebral Edema; Cessation of life; Chronic; Clinical Trials; Clinical Trials, Unspecified; Death; Development; Devices; Dogs; Dose; Drug Metabolic Detoxication; Extrahepatic; Factor Analyses; Factor Analysis; Family suidae; Frequencies (time pattern); Frequency; Fulminating Hepatic Failure; Fulminating Liver Failure; Funding; Future; Hemodialyses; Hemodialysis; Hepatic Cells; Hepatic Encephalopathy; Hepatic Failure; Hepatic Failure, Acute; Hepatic Failure, Fulminant; Hepatic Parenchymal Cell; Hepatocerebral Encephalopathy; Hepatocyte; In Vitro; Individual; Infusion; Infusion procedures; Liver; Liver Cells; Liver Failure; Liver Failure, Acute; Liver Failure, Fulminant; Liver support system; Liver, Artificial; Mammals, Dogs; Membrane; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Modeling; Operation; Operative Procedures; Operative Surgical Procedures; Pathogenesis; Patients; Performance; Permeability; Pigs; Portal-Systemic Encephalopathy; Portosystemic Encephalopathy; Pre-Clinical Model; Preclinical Models; Principal Investigator; Programs (PT); Programs [Publication Type]; Recovery; Research; Research Design; Study Type; Suidae; Supportive Therapy; Supportive care; Surgical; Surgical Interventions; Surgical Procedure; Swine; Testing; Toxin; Transplantation; Treatment Side Effects; United States; base; biocompatibility; bioengineering; bioengineering/biomedical engineering; biomaterial compatibility; body system, hepatic; canine; clinical investigation; design; designing; detoxification; domestic dog; end of life; experiment; experimental research; experimental study; fulminant hepatic failure; hepatic coma/encephalopathy; improved; in vivo; liver function; membrane structure; novel; organ system, hepatic; porcine; programs; research study; response; side effect; study design; suid; surgery; therapy adverse effect; transplant; treatment adverse effect",XENOGENEIC BIOARTIFICAL LIVER,,56733,ZRG1,Special Emphasis Panel,S2,8,99999,
7995817,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK057621-09S1,,NIDDK:80000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CHUA, STREAMSON C;",1881232;,3R01DK057621,02/01/2010,04/30/2010,"Binding; Binding (Molecular Function); Body Composition; Brain; Cell Nucleus; Cells; Complex; Diabetes Mellitus; Eating; Encephalon; Encephalons; Endothelial Cells; Fecundability; Fecundity; Female; Fertility; Food Intake; Goals; HuB219; Hypothalamic structure; Hypothalamus; Immune; Isoforms; LEP-R; LEPR; LEPR Protein; Leptin; Mammals, Mice; Mediating; Mice; Molecular Interaction; Murine; Mus; Muscle, Skeletal; Muscle, Voluntary; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Nucleus; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Protein Isoforms; Regulation; Role; Skeletal Muscle Tissue; Skeletal muscle structure; Syndrome; Transmission; adiposity; cell type; corpulence; corpulency; corpulentia; diabetes; energy balance; hypothalamic; leptin receptor; leptin-binding protein; mammary gland development; neuronal; ob/ob mouse; obese; obese people; obese person; obese population; social role; transmission process",Leptin Receptor and the Obesity/Diabetes Syndrome,,57621,ZRG1,Special Emphasis Panel,S1,9,80000,
7998877,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK057731-08S1,,NIDDK:48639;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW HAVEN,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RUDDLE, NANCY H;",1959466;,3R01DK057731,01/15/2010,03/31/2010,"Acute; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cachectin Receptors; Cell Communication and Signaling; Cell Signaling; Characteristics; Chronic; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; EC 2.8.2; Fluorescence; Generalized Growth; Genes; Genes, LacZ; Goals; Growth; High Endothelial Venule; IDD; IDDM; INFLM; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inflammation; Insulin-Dependent Diabetes Mellitus; Intracellular Communication and Signaling; LTA; LacZ; LacZ Genes; Ligands; Lymphangiogeneses; Lymphangiogenesis; Lymphatic vessel; Lymphoid; Lymphotoxin; Lymphotoxin A; Lymphotoxin-alpha; MECA-79 antigen; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Mammals, Mice; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mice; Murine; Mus; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Organ; PNAd; Phenotype; Recovery; Regulation; Role; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Staging; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNF Superfamily, Member 1; TNF-b; TNF-beta; TNFR; TNFSF1; Testing; Tetracycline Antibiotic; Tetracyclines; Time; Tissue Growth; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor-Beta; Type 1 diabetes; Zeugmatography; biological signal transduction; density; inhibitor; inhibitor/antagonist; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; macrophage; novel; ontogeny; peripheral lymph node addressin; self recognition (immune); social role; sulfotransferase; type I diabetes",Lymphotoxin and Lymphoid Neogenesis,,57731,ZRG1,Special Emphasis Panel,S1,8,48639,
7997942,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK057838-09S1,,NIDDK:3147;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PORTLAND,UNITED STATES,NONE,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"MORRISON, SHAUN F;",1909922;,3R01DK057838,01/15/2010,03/31/2010,"Address; Adipose Tissue, Brown; Agonist; Anatomic; Anatomical Sciences; Anatomy; Animals; Arcuate Nucleus; Automobile Driving; Autoregulation; Behavior; Body Temperature Regulation; Body Thermoregulation; Body Tissues; Body Weight; Brain; Brain Stem; Brain region; Brainstem; Brown Fat; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Central gray substance of midbrain; Chronotropism, Cardiac; Chronotropisms, Cardiac; Common Rat Strains; Cutaneous; D-Glucose; Data; Development; Dextrose; Diabetes Mellitus; Dinoprostone; Drivings, Automobile; Drug Iontophoresis; Efferent Pathways; Encephalon; Encephalons; Energy Expenditure; Energy Metabolism; Equation; Fever; Figs; Figs - dietary; Foundations; Funding; Genetic Models; Glucose; Glutamates; Health; Healthcare Systems; Heart Rate; Heat Production; Hibernating Gland; Homeostasis; Human; Human, General; Humulin R; Hyperthermia; Hypothalamic structure; Hypothalamus; Individual; Infant; Infundibular Nucleus; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Investigators; Iontophoresis; L-Glutamate; Leptin; Lesion; METBL; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesencephalic Central Gray; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Microinjections; Midbrain Central Gray; Modeling; Models, Genetic; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Pathways; Neurochemistry; Neurocyte; Neurons; Neurotransmitters; News; News (PT); News [Publication Type]; Novolin R; Nucleus; O element; O2 element; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Oxygen; PGE2; PGE2 alpha; PGE2alpha; Pathway interactions; Peptides; Periaqueductal Gray; Pharmacology; Physiologic; Physiologic Thermoregulation; Physiological; Physiological Homeostasis; Physiology; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Population; Predisposition; Preoptic Areas; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Progress Reports; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Pyrexia; QOL; Quality of life; Rat; Rattus; Regulation; Reports, Progress; Reproduction; Research; Research Personnel; Researchers; Role; Science of Anatomy; Science of neurochemistry; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Spinal; Structure of nucleus infundibularis hypothalami; Suggestion; Susceptibility; Synapses; Synaptic; System; System, LOINC Axis 4; Systems, Health Care; TXT; Techniques; Temperature; Testing; Text; Therapeutic; Thermogenesis; Thermoregulation; Time; Tissues; Vasoactive Agonists; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Work; adiposity; anatomy; annulus of the aqueduct; base; biological signal transduction; corpulence; corpulency; corpulentia; diabetes; driving; expectation; experiment; experimental research; experimental study; febrile; febris; feeding; heart circulation; hypothalamic; improved; in vivo; iontophoresis therapy; midbrain central gray substance; neural circuit; neural circuitry; neurochemistry; neuronal; neurotransmitter agonist; news; ob/ob mouse; obese; obese people; obese person; obese population; pathway; periaqueductal gray matter; preoptic region; programs; research study; response; social role; vasopressor",Central Regulation of Sympathetic Activity to Brown Fat,,57838,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,9,3147,
8009634,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK057892-09S2,,NIDDK:98782;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","MURRAY, JOSEPH A;",6267017;,3R01DK057892,01/15/2010,12/31/2010,"21+ years old; Active Follow-up; Address; Adult; Affect; Age; Age-Years; Ailmentary System; Alimentary System; American; Anemia; Armed Forces Personnel; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Serum; CD28; CD28 gene; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Celiac Disease; Chronic; Chronic Disease; Chronic Illness; Cohort Studies; Collection; Communities; Comorbidity; Complement; Complement Proteins; Concurrent Studies; Consensus; County; Data; Detection; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diagnosis; Diagnostic; Diet; Digestive Diseases; Digestive System; Digestive System (All Sites); Digestive System Diseases; Digestive System Disorders; Disease; Disease Association; Disorder; Early Diagnosis; Environment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Exclusion; Family member; Funding; Gastrointestinal Body System; General Population; General Public; Glutelin; Gluten; Gluten Enteropathy; Gluten-Sensitive Enteropathy; Goals; HCV infection; Health; Hepatitis; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Human; Human, Adult; Human, General; IDD; IDDM; Incidence; Individual; Inflammatory; Inpatients; Insulin-Dependent Diabetes Mellitus; Investigation; Investigators; Knowledge; Life; Link; MGUS; Man (Taxonomy); Man, Modern; Medical; Medical Records; Military; Military Personnel; Minnesota; Monoclonal Gammopathy of Undetermined Significance; Monoclonal Gammopathy of Unknown Significance; Monoclonal gammopathy of uncertain significance; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NANBH; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Organ System, Gastrointestinal; Out-patients; Outcome; Outpatients; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Population; Population Study; Prevalence; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Recommendation; Records; Relative; Relative (related person); Research Personnel; Research Resources; Researchers; Resources; Sampling; Screening procedure; Serologic; Serologic tests; Serological; Serological Tests; Serum; Sprue, Celiac; Sprue, Nontropical; Symptoms; T1 diabetes; T1D; T1DM; T44; Testing; Time; Type 1 diabetes; United States National Institutes of Health; Work; Wyoming; abstracting; adult human (21+); adult youth; base; chronic disease/disorder; chronic disorder; cohort; computerized; conference; diabetes; digestive disorder; disease diagnosis; disease/disorder; early detection; epidemiologic data; experience; follow-up; gastrointestinal system; hepatitis non A non B; hepatitis nonA nonB; idiopathic steatorrhea; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; population based; programs; public health medicine (field); sample collection; screening; screenings; serology; specimen collection; symposium; type I diabetes; young adult",Epidemiology of Celiac Disease: A Population Based Study,,57892,ZRG1,Special Emphasis Panel,S2,9,98782,
7992531,R01,DK,3,Y,01/01/2010,09/30/2010,PA-07-070,3R01DK058058-08S1,,NIDDK:15000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DETROIT,UNITED STATES,PHYSIOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"SHISHEVA, ASSIA ;",6372414;,3R01DK058058,01/01/2010,09/30/2010,"Ablation; Address; Adipocytes; Adipose Cell; Affect; Area; Autoregulation; Binding; Binding (Molecular Function); Biogenesis; Biological Models; C elegans; C.elegans; CURL; Caenorhabditis elegans; Cancers; Cardiovascular Diseases; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell physiology; Cellular Function; Cellular Migration; Cellular Morphology; Cellular Physiology; Cellular Process; Communicable Diseases; Compartment of the Uncoupling Receptors and Ligands; Complex; Couples; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Destinations; Diabetes Mellitus; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drosophila; Drosophila genus; Early Endosome; Embryo; Embryonic; Endocrine; Endocytosis; Endosomes; Environment; Enzymes; Fat Cells; Fruit Fly, Drosophila; Funding; Genes; Glucose Binding Protein; Glucose Transporter; Goals; Homeostasis; Human; Human, General; Humulin R; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Investigators; Kinesin; Knowledge; Lipids; Lipocytes; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammalian Cell; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Membrane; Membrane of the Endosome; Methods and Techniques; Methods, Other; Micro-tubule; Microtubules; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Monitor; Morphology; Motility; Motility, Cellular; Motor; Novolin R; Origin of Life; Outcome; Paper; Pathway interactions; Peer Review; Performance; Phosphatases; Phosphatidyl Inositol; Phosphatidylinositols; Phosphohydrolases; Phosphoinositides; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiological; Physiological Homeostasis; Physiology; Prevention strategy; Preventive strategy; Process; Production; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Binding; Proteins; PtdIns; Reagent; Receptor Protein; Receptosomes; Recruitment Activity; Regulation; Reports, Progress; Research; Research Personnel; Researchers; Role; Subcellular Process; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic Intervention; Time; Transport Protein, Glucose; Transport Vesicles; VESCL; Vacuole; Vesicle; Work; adapter protein; base; cardiovascular disorder; cell morphology; cell motility; clinical data repository; clinical data warehouse; d-Numb; data repository; diabetes; disease/disorder; endosome membrane; fruit fly; gene product; glucose transport; glucose uptake; innovate; innovation; innovative; intervention therapy; malignancy; membrane structure; mutant; neoplasm/cancer; novel; numb protein; pathogen; pathway; programs; receptor; recruit; relational database; social role",Functions of adipocyte PIKfyve and its lipid products,,58058,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,8,15000,
7994258,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK058214-07S1,,NIDDK:92677;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"BULL, LAURA N;",1910531;,3R01DK058214,01/15/2010,12/31/2010,"(5-L-Glutamyl)-peptide[{..}]amino-acid 5-glutamyltransferase; 15q26; 3-ketosteroid isomerase; 3-oxo-delta(5)-steroid isomerase; 3-oxosteroid delta 4-5 isomerase; 5-ene-3-ketosteroid isomerase; 5-ene-4-ene-steroid isomerase; 5-pregnene-3,20-dione isomerase; ATP phosphohydrolase; ATPase; Acids, Bile; Adenosine Triphosphatase; Adenosinetriphosphatase; Admixture; Affect; African; Alleles; Allelomorphs; Alopecia; Alpha-mannosidase; Amerinds, North American; Amish; Amyoplasia Congenita; Area; Arthrogryposis; Arthromyodysplasia, Congenital; Arts; Assay; Avian Sarcoma; Baldness; Benign familial recurrent cholestasis; Benign recurrent cholestasis; Benign recurrent intrahepatic cholestasis; Bile; Bile Acids; Bile Duct Obstruction; Bile Juice; Bile Salt; Bile fluid; Biliary Stasis; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Blood Serum; Blood leukocyte; Byler's disease; Byler's syndrome; CLDN1; Candidate Disease Gene; Candidate Gene; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Causality; Cessation of life; Childhood; Chile; Cholangiitis, Sclerosing; Cholangitis, Sclerosing; Cholestasis; Cholestasis of pregnancy; Cholestasis, progressive familial intrahepatic; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chromosome 15; Chromosomes, Human, Pair 15; Cirrhosis; Clinical; Code; Coding System; Cohort Studies; Complex; Concurrent Studies; Congenital Arthromyodysplasias; Connective Tissue Sarcoma; Core Facility; County; Cytokinesis; Cytoplasmic Division; DNA; Data; Death; Dehydrogenases; Deoxyribonucleic Acid; Development; Diagnosis; Dibasic Processing Enzyme; Disease; Disorder; Dysfunction; EC 3.3.2.3; EPHX; EPHX1; EPHX1 gene; EPOX; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Pulsed-Field Gradient; Enrollment; Epoxide Hydrolase 1; Epoxide Hydroxylase 1, Microsomal; Epoxide Hydroxylase 1, Microsomal (Xenobiotic); Etiology; Evaluation; FES; FPS; FPS-FES Oncogene; FURIN; FURIN gene; Familial intrahepatic cholestasis; Family; Family Felidae; Fatal familial intrahepatic cholestasis syndrome; Fatal intrahepatic cholestasis; Felidae; Felids; Fetal Distress; Follow-Up Studies; Followup Studies; Fractionation, Pulse Field; Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene; Functional disorder; Furin Preproprotein; Furin Protein; GGT; GGTP; Gamma-GT; Gamma-glutamyl transferase; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic defect; Genomics; Genotype; Glutamyl Transpeptidase; Goals; Grafting, Liver; Guerin-Stern Syndrome; HPLC; Haplotypes; Health; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Hereditary; High Pressure Liquid Chromatography; Homolog; Homologous Gene; Homologue; Human; Human, General; Ichthyoses; Impairment; Incidence; Indians, North American; Individual; Inherited; Inherited Predisposition; Inherited Susceptibility; Investigation; Investigators; Kidney; Knowledge; Latina; Leiomyocyte; Lesion; Leukocytes; Liver; Liver Cells; Liver Transplant; Liver diseases; Lymphatic System; Lymphatic system (all sites); Lymphedema; MDR2 protein; MDR3 protein; MEH; Maintenance; Maintenances; Malignant Soft Tissue Neoplasm; Malignant Tumor of the Soft Tissue; Man (Taxonomy); Man, Modern; Maps; Marrow leukocyte; Membrane Transport Proteins; Membrane Transporters; Methods; Microsomal Epoxide Hydrolase; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutate; Mutation; Myocytes, Smooth Muscle; Myodystrophia Fetalis Deformans; NIH; Na element; National Institutes of Health; National Institutes of Health (U.S.); Native Americans; Neutral alpha-Mannosidase; North American Indians; Occidental; Occluding Junctions; Oncogene FES; Oncogene, FPS-FES; Otto syndrome; Oxidoreductase; PACE Gene; PACE Protein; PCR; PCSK3; PFGE; PGY3 gene product; PRC1; PRC1 Protein; Paired Basic Amino Acid Cleaving Enzyme Gene; Participant; Patients; Performance; Perinatal Mortalities; Perinatal mortality demographics; Pharmacogenetics; Physiopathology; Play; Polycomb Repressive Complex 1; Polymerase Chain Reaction; Polymorphism, Single Base; Predisposition; Predisposition gene; Premature Birth; Preterm Birth; Process; Programs (PT); Programs [Publication Type]; Progressive intrahepatic cholestasis; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Export; Protein Export Pathway; Proteins; RNA Splicing; Recurrent intrahepatic cholestasis of pregnancy; Recurrent jaundice of pregnancy; Reductases; Reporting; Research; Research Personnel; Research Specimen; Researchers; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Lymphatic System; Risk; Rocher-Sheldon syndrome; Role; Rossi syndrome; SNP; SNPs; SPC1; SPC1 Proteinase; Salts, Bile; Sampling; San Francisco; Sarcoma of the Soft Tissue and Bone; Sarcoma, Avian; Sarcoma, Soft Tissue; Scandinavian; Sclerosing Cholangitis; Screening procedure; Serum; Short Tandem Repeat; Simple Sequence Repeat; Single Nucleotide Polymorphism; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Societies; Sodium; Specimen; Splicing; Steroid Compound; Steroid delta-isomerase; Steroids; Study of serum; Susceptibility; Susceptibility Gene; Synaptic Vesicles; Syndrome; Testing; Tight Junctions; Transplantation of liver; Transplantation, Hepatic; UTRs; United States National Institutes of Health; Untranslated Regions; Urinary System, Kidney; VPS; Vacuolar Protein Sorting; Vacuole; Variant; Variation; Viral; Viral Oncogene; White Blood Cells; White Cell; Woman; Zonula Occludens; alpha-D-Mannosidase; alpha-D-Mannoside Mannohydrolase; arthrogryposis multiplex congenita; arthrogryposis multiplex congenita (AMC); base; bile acid transporter; bile acid-CoA amino acid N-acyltransferase; bile acid-coenzyme A amino acid N-acyltransferase; bile obstruction; bile occlusion; bile salts; body system, hepatic; chronic obliterative cholangitis; claudin-1; claudin-1 protein; cohort; congenital arthromyodysplastic syndrome; congenital contractures of extremities; cost; delta 5-3-oxosteroid isomerase; delta(5)-3-ketosteroid isomerase; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; enroll; experiment; experimental research; experimental study; feline; fibrosing cholangitis; gamma glutamyltranspeptidase; gamma-Glutamyl Transpeptidase; gamma-Glutamyltransferase; gammaglutamyltransferase; gene product; genetic etiology; genetic mechanism of disease; genetic promoter element; genetic variant; genetic vulnerability; genome mutation; hepatopathy; improved; insight; intrahepatic cholestasis of pregnancy; liver disorder; liver transplantation; mdr-3 protein; mdr2 gene product; mdr2-3 gene product; mdr3 gene product; member; multi-drug resistance protein 3; multi-drug resistant protein 3; multidrug resistance protein 3; multiple congenital contractures; myodysplasia fibrosa multiplex; myodysplasia foetalis deformans; myodystrophia foetalis deformans; neuro-arthromyodysplasia; organ system, hepatic; paired basic amino acid cleaving enzyme; pathophysiology; pediatric; predisposing gene; premature childbirth; premature delivery; preterm delivery; programs; renal; research study; sarcoma; screening; screenings; serology; social role; steroid 5-4-ene-isomerase; white blood cell; white blood corpuscle; white race",The Genetic Basis of Hereditary Liver Disease,,58214,GHD,Genetics of Health and Disease Study Section,S1,7,92677,
8012887,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK058694-07A1S1,,NIDDK:75620;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MINNEAPOLIS,UNITED STATES,SURGERY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"SALUJA, ASHOK K;",6489156;,3R01DK058694,02/01/2010,01/31/2011,"70-kD Heat-Shock Protein; APP Secretase; Acinar Cell; Aciner Cells; Acinus organ component; Amyloid Precursor Protein Secretase; Animal Model; Animal Models and Related Studies; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Applications Grants; Arginine; Arginine, L-Isomer; Attenuated; Autoregulation; Blood Coagulation Factor IV; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Ca++ element; Caerulein; Calcium; Caring; Caspase 3, Apoptosis-Related Cysteine Protease; Cathepsin B1; Cathepsins B; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell-Death Protease; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Ceruletid; Ceruletide; Coagulation Factor IV; Cysteine Protease CPP32; Cytosol; Data; Diagnosis; Disease; Disorder; Dysfunction; EC 3.4.22.1; Enzyme Precursors; Enzymes; Event; Factor IV; Functional disorder; Gastrointestinal Tract, Pancreas; Grant Proposals; Grants, Applications; HSP; HSP 70; HSP70; Heat shock proteins; Heat-Shock Proteins 70; Homeostasis; ICE-like protease; INFLM; In Vitro; Inflammation; Inflammatory; Injury; L-Arginine; Laboratories; Lead; Modeling; Organelles; PARP Cleavage Protease; Pancreas; Pancreatic; Pancreatitis; Pathogenesis; Patients; Pb element; Physiological Homeostasis; Physiopathology; Play; Proenzymes; Publications; Role; SCA-1; SREBP Cleavage Activity 1; Scientific Publication; Series; Stimulus; Stress Proteins; Subcellular Process; Testing; Time; Time Study; Tripcellim; Trypsin; Trypsinogen; Yama; Yama protein; Zymogens; abstracting; acinus; acute pancreatitis; base; caspase; caspase-3; cell damage; cell injury; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; disease/disorder; heavy metal Pb; heavy metal lead; hsp70 Family; in vivo; model organism; necrocytosis; novel; overexpression; pathophysiology; prevent; preventing; public health relevance; response; social role; treatment strategy",Heat Shock Proteins and Pancreatitis," Abstract Pancreatitis is an inflammatory disease of the pancreas. Every year, over 225,000 patients are diagnosed with pancreatitis and over two billion dollars are spent on their care. However, there is currently no treatment for these patients besides conservative management. It is thus necessary that we understand the pathogenesis of this disease so that specific treatment strategies can be developed. The current understanding of the pathogenesis of pancreatitis suggests that events culminating in inflammation of the pancreas are initiated in the acinar cells which synthesize, store, and secrete digestive enzymes in an inactive form. There is evidence that, early in pancreatitis, digestive enzymes are activated intracellularly; these activated digestive enzyme zymogens are believed to be the injury-inciting stimuli. Several publications from our laboratory have shown that early on in pancreatitis, the inactive digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen. This is corroborated by the fact that inhibiting cathepsin B protects against trypsinogen activation as well as injury during pancreatitis. Until now, cathepsin B in pancreatitis was believed to simply activate digestive enzyme zymogens. Now, however, recent studies in our laboratory have shown that cathepsin B can play a role in the activation of the apoptotic cascade and acinar cell injury during pancreatitis independently of digestive enzyme zymogen activation. This is a new paradigm in the pathophysiology of pancreatitis. Also we have demonstrated for the first time that co-localized organelles become permeabilized in pancreatitis, leading to release of cathepsin B into the cytosol, where it activates the apoptotic cascade. In this grant proposal, we will confirm this exciting and novel finding that, during pancreatitis, cathepsin B released from the co-localized organelles activates apoptosis through a series of in vitro and in vivo studies. Also, the mechanism by which co-localized organelles are permeabalized as well as the mechanism by which cathepsin B activates apoptosis during pancreatic acinar cell will be explored. We have also shown that HSP70 (heat shock protein 70) expression protects against pancreatitis. Our preliminary data suggest that HSP70 does so by preventing co-localization and eventually inhibiting cathespsin B release into the cytosol. Our preliminary studies have also shown for the first time in pancreatic acinar cells that HSP70 attenuates cytosolic calcium elevation in response to caerulein stimulation. Based on these facts as well as on our preliminary data that cytosolic calcium is important for co-localization, we have proposed that novel hypothesis that HSP70 inhibits co-localization in pancreatic acinar cells by attenuating cytosolic calcium and thus protects against injury in pancreatitis. In this grant proposal, we will investigate the mechanism by which HSP70 attenuates cytosolic calcium. Since intracellular calcium is known to be involved in numerous and diverse cellular processes, this aim is significant beyond pancreatitis.",58694,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,A1S1,7,75620,
7997830,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK059904-08S2,,NIDDK:154463;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,GENETICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"FRIDOVICH-KEIL, JUDITH L.;",1863155;,3R01DK059904,02/01/2010,01/31/2011,"ATP[{..}]D-galactose 1-phosphotransferase; Acute; Animal Disease Models; Biochemical; Biological Models; Blood Plasma; Blood Sample; Blood Serum; Blood specimen; Cell Culture Techniques; Cell model; Cells; Cellular model; Chiro-Inositol; Classical galactosemia; Clinical; Code; Coding System; Cognitive; Consumption; D-Galactose; DNase; Data; Defect; Deficiency Disease, Galactose-1-Phosphate Uridyl-Transferase; Deoxyribonucleases; Development; Disease; Disorder; Dose; Dysfunction; Early Diagnosis; Embryo; Embryonic; Engineering; Engineerings; Enzyme Inhibition; Enzymes; Exposure to; FLR; Failure (biologic function); Female; Fibroblasts; Functional disorder; Galactitol; Galactopyranose; Galactopyranoside; Galactose; Galactose Metabolism; Galactose Metabolism Pathway; Galactose-1-Phosphate Uridyltransferase; Galactosemia; Galactosemia, Classic; Galactosemias; Galactosemias, Classic; Galactosephosphate Uridylyltransferase; Genotype; Glycans; Glycoproteins; Goals; Golgi; Golgi Apparatus; Golgi Complex; Granulocyte/Pollen-Binding Protein; Hereditary Metabolic Disorder; Human; Human, General; Impairment; Inborn Errors of Metabolism; Individual; Inositol; Investigation; Investigators; Knockout Mice; Language; Language Disorders; Language disability; Lymphocytes, Null; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Mesoinositol; Metabolic; Metabolic Glycosylation; Metabolism, Inborn Errors; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Monosaccharides; Murine; Mus; N-Acetylneuraminic Acids; Nature; Nucleases, DNA; Null Cells; Null Lymphocytes; Null Mouse; Outcome; Ovarian; Ovarian Failure, Premature; Patients; Phenotype; Physiopathology; Plasma; Polysaccharides; Premature Ovarian Failure; Process; Proteins; Recruitment Activity; Reporter; Research; Research Personnel; Researchers; Residual; Residual state; Reticuloendothelial System, Serum, Plasma; Role; Sampling; Secondary to; Serum; Serum, Plasma; Sialic Acids; Siderophilin; Speech; Statistical Study; Study Subject; Study, Statistical; Testing; Transferrin; UDP Galactose Epimerase; UDP Galactose Pyrophosphorylase; UDP Glucose Epimerase; UDP-Galactose 4-Epimerase; UDP-Glucose 4-Epimerase; UDPgalactose 4-Epimerase; UDPglucose 4-Epimerase; UDPglucose Hexose-1-Phosphate Uridylyltransferase Deficiency; UTP Hexose-1-Phosphate Uridylyltransferase Deficiency; UTP-Hexose-1-Phosphate Uridylyltransferase; UTP[{..}]alpha-D-hexose-1-phosphate uridylyltransferase; Uridine Diphosphate Glucose Epimerase; Variant; Variation; Yeasts; base; cohort; diet restriction; dietary restriction; disability; disease/disorder; early detection; effective therapy; epimerase; experience; failure; galactokinase; galactose 1 phosphate uridylyl transferase deficiency; galactose 1 phosphate uridylyltransferase; gene product; glycosylation; inborn metabolism disorder; language deficit; lipid-linked oligosaccharides; lipooligosaccharide; lymphoblast; novel; overexpression; pathophysiology; prevent; preventing; recruit; response; restricted diet; social role; streptolysin O; sugar nucleotide",Bases of Pathophysiology in Galactosemia,,59904,ZRG1,Special Emphasis Panel,S2,8,154463,
8009194,R01,DK,3,Y,01/15/2010,12/31/2010,PA-07-070,3R01DK060019-07S1,,NIDDK:139750;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHEN, HONGWU ;",1927168;,3R01DK060019,01/15/2010,12/31/2010,"ACTR; ACTR protein, human; AIB1; AIB1 (protein); ATP phosphohydrolase; ATPase; ATPase Domain; Adenosine Triphosphatase; Adenosinetriphosphatase; Amplified in Breast Cancer; Amplified in Breast Cancer 1 Protein; Aquadiol; Biochemistry; Biological; Body Tissues; Breast Cancer Cell; Bromodomain; CAGH16; CTG26; Cancer Genes; Cancer of Breast; Cancer of Endometrium; Cancer-Promoting Gene; Carcinoma of Endometrium; Cell Communication and Signaling; Cell Cycle Control; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cellular Proliferation; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Chromatin; Clinical; Complex; Corpus Luteum Hormone; Delta4-pregnene-3,20-dione; Dimenformon; Diogyn; Diogynets; ERalpha; Endocrine Diseases; Endocrine Diseases and Manifestations; Endocrine Gland Secretion; Endocrine System Diseases; Endocrinology; Endometrial Cancer; Endometrial Carcinoma; Enzymes; Epithelial; Epithelial Cell Proliferation; Epithelial Cells; Epithelium; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol Receptor alpha; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptor alpha; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrus; Event; Family; Female; Forecast of outcome; Gene Expression; Gene Expression Process; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Genital System, Female, Uterus; Goals; Growth; Hormonal; Hormone Receptor; Hormones; Human; Human Breast Cancer Cell; Human, General; Intracellular Communication and Signaling; Investigation; Level of Evidence; Link; Malignant Cell; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Menstrual cycle; Metabolism and Endocrinology; Mice; Mitogenesis; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Murine; Mus; NCOA3; NCOA3 gene; Nuclear; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nuclear Protein; Nuclear Proteins; Nuclear Receptor Coactivator 3; Nuclear Receptors; Oncogenes; Ovocyclin; Ovocylin; Physiologic; Physiological; Play; Positive Control of Cell Proliferation; Pregn-4-ene-3,20-dione; Pregnenedione; Principal Investigator; Process; Progesterone; Progesterone Receptors; Prognosis; Programs (PT); Programs [Publication Type]; Progynon; Proteins; RAC3; RAC3 protein; RNA Expression; Receptor Protein; Receptor-Associated Coactivator 3; Receptors, Progesterone; Receptors, Progestin; Receptors, Steroid; Regulation; Reproduction; Role; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Steroid Receptors; Stimulation of Cell Proliferation; TNRC14; TNRC16; TRAM-1; Targetings, Gene; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Thyroid Hormone Receptor Activator Molecule; Tissue Growth; Tissue Transplantation; Tissues; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Transforming Genes; Up-Regulation; Uterus; Work; activator of thyroid and retinoic acid receptor protein, human; biological signal transduction; cancer cell; cellular targeting; chromatin remodeling; cofactor; discovery mining; endocrine disorder; estrous; gene product; histone modification; insight; literature mining; literature searching; malignant breast neoplasm; mammary; member; novel; ontogeny; outcome forecast; overexpression; p/CIP; progesterone receptor; programs; protein complex; protein function; receptor; receptor function; reconstruction; reproductive; response; social role; steroid receptor coactivator AIB1; text mining; text searching; thyroid hormone receptor activator molecule 1; transcription factor; tumor; womb",Nuclear cofactors in hormone signaling,,60019,MCE,Molecular and Cellular Endocrinology Study Section,S1,7,139750,
8010742,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK060043-09S1,,NIDDK:106785;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"BOTTINGER, ERWIN P.;",2095049;,3R01DK060043,01/15/2010,12/31/2010,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; ALK-5 protein; ALK-5 receptor; ALK5; Activin A Receptor Type II-Like Kinase 53kDa; Activin Receptor-Like Kinase 5; Adaptor Protein; Adaptor Signaling Protein; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); CD2-associated protein; CD2AP protein; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Complex; Diabetic Kidney Disease; Diabetic Nephropathy; Diabetic mouse; Diathesis; Disease susceptibility; Down-Regulation; Down-Regulation (Physiology); Downregulation; Doxycycline; EC 2.7; Epithelial; Epithelial Cells; Genetic Algorithm; Genetic Alteration; Genetic Change; Genetic Programming; Genetic defect; Genotype; Glomerular disease; Grant; Human; Human, General; In Vitro; Injury; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Kidney; Kidney Diseases; Kinases; Knockout Mice; Lesion; Life; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Models, Structural; Molecular; Molecular Interaction; Murine; Mus; Mutation; Nephropathy; Null Mouse; Parietal; Pathway interactions; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphotransferases; PtdIns; Receptor Protein; Receptor Signaling; Regulation; Renal Disease; Renal Glomerular Diseases and Syndromes; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Role; SKR4; Serine/Threonine-Protein Kinase Receptor R4; Signal Transduction; Signal Transduction Systems; Signaling; Structural Models; TGF-beta type I receptor; TGFBR-1; TGFBR1; Technology; Testing; Transforming Growth Factor Beta Receptor I; Transforming Growth Factor Beta Receptor Type I; Transgenes; Transgenic Organisms; Transphosphorylases; Tubular; Tubular formation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; Vibramycin; Visceral Epithelial Cell; Work; alpha-6-Deoxyoxytetracycline; base; biological signal transduction; diabetic; disease/disorder proneness/risk; genome mutation; glomerular sclerosis; glomerular visceral epithelial cell; glomerulosclerosis; in vivo; kidney disorder; liability to disease; men; men's; mouse model; mouse model of diabetes; novel; pathway; podocyte; prevent; preventing; protein complex; protein expression; protein function; receptor; renal; renal disorder; slit diaphragm; social role; transgenic",Genetic Programming in Progressive Renal Disease,,60043,ZRG1,Special Emphasis Panel,S1,9,106785,
8007006,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK060521-07S1,,NIDDK:50000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MINNEAPOLIS,UNITED STATES,PHARMACOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"WEI, LI-NA ;",1866137;,3R01DK060521,01/07/2010,12/31/2010,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 9-cis-Retinoic Acid Receptor; ATRA; Address; Adipocytes; Adipose Cell; Affect; All-trans retinoic acid; Animal Model; Animal Models and Related Studies; Arginine; Arginine, L-Isomer; Autoregulation; Biological; Biological Function; Biological Process; CRABP I; CRSP1; CRSP200; Carcinoma, Embryonal; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Chemotherapy-Hormones/Steroids; Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Clinical; Complex; DNA-Dependent RNA Polymerase II; DRIP230; Defect; Disease; Disorder; EC 2; EP300; EP300 gene; Embryo; Embryonal Carcinoma; Embryonic; Endocrine; Endocrine Gland Secretion; Event; Fat Cells; Fibroblasts; Figs; Figs - dietary; Gene Conversion; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Goals; HDAC; HDAC Proteins; Health; Histone Deacetylase; Histones; Homeostasis; Hormonal; Hormone Receptor; Hormones; Human; Human, General; Intracellular Communication and Signaling; Kinetic; Kinetics; Knock-out; Knockout; Knowledge; L-Arginine; Left; Ligands; Lipocytes; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Diseases; Metabolic Disorder; Methylation; Mice; Modeling; Modification; Molecular; Molecular Mechanisms of Action; Murine; Mus; Mutate; NRIP1; NRIP1 Protein; NRIP1 gene; NRIP1 protein, human; Nuclear Receptor Interacting Protein 1; Nuclear Receptors; Nucleic Acid Regulatory Sequences; Nucleosomes; Nutrient; Nutritional; P/CAF; PCAF; PCAF gene; PPARBP; PPARBP gene; PPARGBP; Phase; Physiological Homeostasis; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; RB18A; RIP140; RIP140 Protein; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA, Small Interfering; RXR; RXR Protein; Receptor Interacting Protein 140; Receptor Interacting Protein, 140 kDa; Receptor Protein; Recruitment Activity; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reports, Progress; Repression; Retinoic Acid; Retinoic Acid Binding; Retinoic Acid Receptor; Retinoic Acid Receptor RXR; Retinoid X Receptors; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Supplementation; System; System, LOINC Axis 4; TRAP220; TRIP2; Targetings, Gene; Testing; Therapeutic Hormone; Thesaurismosis; Thyroid Gland Hormone; Thyroid Hormones; Trans Vitamin A Acid; Transcription; Transcription, Genetic; Transferase; Tretinoin; Tretinoinum; Vitamin A; Vitamin A Acid; adipocyte development; adipocyte differentiation; all-trans-Retinoic Acid; all-trans-Vitamin A acid; biological signal transduction; cell type; cellular retinoic acid binding protein I; chromatin remodeling; disease/disorder; genetic regulatory element; genetically modified cells; hormone response element; human NRIP1 protein; insight; metabolism disorder; model organism; mouse model; mutant; novel; p300; programs; public health relevance; receptor; recruit; retinoic acid binding protein I, cellular; retinol; siRNA; social role; trans-Retinoic Acid; transcription factor","Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways",,60521,INMP,Integrative Nutrition and Metabolic Processes Study Section,S1,7,50000,
8011603,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK060715-07S1,,NIDDK:67447;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STANFORD,UNITED STATES,PEDIATRICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"SIBLEY, ERIC ;",1889011;,3R01DK060715,02/01/2010,01/31/2011,"21+ years old; Adult; Age; Aging; Ailmentary System; Alimentary System; Animals; Assay; Attention; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Carbohydrates; Cell Culture Techniques; Combining Site; Common Rat Strains; Complement; Complement Proteins; Consumption; DNA; DNA Alteration; DNA Binding; DNA Binding Interaction; DNA Sequence; DNA mutation; Dairy Products; Deoxyribonucleic Acid; Digestive System; Digestive System (All Sites); Elements; Enterocytes; Enzymes; Epithelial Cells; Funding; Future; Gastrointestinal Body System; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gene Alteration; Gene Expression; Gene Mutation; Gene Transcription; Genes; Genetic Determinism; Genetic Polymorphism; Genetic Transcription; Genetic mutation; Goals; Human; Human, Adult; Human, General; In Situ; In Vitro; Intestinal; Intestinal Diseases; Intestinal Disorder; Intestines; Investigation; Knowledge; Lactase; Lactase Enzyme; Lactose Galactohydrolase; Lactose Intolerance; Lactose Malabsorption; Life; Macronutrients; Macronutrients Nutrition; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Milk; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Murine; Mus; Nuclear Protein; Nuclear Proteins; Nucleotides; Nutrition, Macronutrients; Organ System, Gastrointestinal; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); R01 Mechanism; R01 Program; RNA Expression; RPG; Rat; Rattus; Reactive Site; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rodent; Rodentia; Rodentias; Role; SNP; SNPs; Senescence; Sequence Alteration; Single Nucleotide Polymorphism; Specific qualifier value; Specified; Therapeutic; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transgenic Mice; Transgenic Organisms; Up-Regulation; Variant; Variation; adult human (21+); bowel; directed attention; directs attention; enzyme activity; gastrointestinal disorder; gastrointestinal system; genetic determinant; human DNA sequencing; in vivo; intestine disorder; new approaches; new diagnostics; next generation diagnostics; novel approaches; novel diagnostics; novel strategies; novel strategy; polymorphism; prevent; preventing; prognostic; protein function; public health relevance; senescent; social role; spatiotemporal; transcription factor; transgene expression; transgenic",Spatiotemporal Regulation of Intestinal Gene Expression," Project Narrative Statement of Public Health Relevance Adult-onset hypolactasia, lactase non-persistence, renders much of the world's adult human population intolerant of excessive consumption of milk and other dairy products. In some adults, however, high levels of lactase enzyme activity persist in adulthood presumably due to inheritance of a genetic mutation that prevents the normal maturational decline in lactase expression. Knowledge of mechanisms regulating expression of the digestive lactase gene may provide novel strategies for enhancing expression of digestive enzymes in intestinal diseases and will have broad implications for understanding regulation of other genes with aging.",60715,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,S1,7,67447,
8009573,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK061317-07S1,,NIDDK:98899;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WEST LAFAYETTE,UNITED STATES,PSYCHOLOGY,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"POWLEY, TERRY L.;",1867716;,3R01DK061317,01/07/2010,12/31/2010,"Accounting; Address; Affect; Afferent Neurons; Age; Aged 65 and Over; Aging; Algorithms; Alimentary Canal; Animal Model; Animal Models and Related Studies; Appetite; Assay; Auerbach's Plexus; Bioassay; Biologic Assays; Biological Assay; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Central Nervous System; Chemicals; Clinical; Connector Neuron; Desire for food; Digestion; Digestive Diseases; Digestive System Diseases; Digestive System Disorders; Digestive Tract; Disease; Disorder; Elderly; Elderly, over 65; Elements; Enteral; Enteric; Enteric Nervous System; Evolution; Foundations; Functional Gastrointestinal Disorders; GI Tract; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gastrointestinal Disorders, Functional; Gastrointestinal Motility; Gastrointestinal Tract; Gastrointestinal tract structure; Goals; Health; Ingestion; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intervention; Intervention Strategies; Intestinal; Intestines; Length of Life; Link; Longevity; Maps; Meissner's Plexus; Methods and Techniques; Methods, Other; Motility; Motility, Cellular; Motor; Motor Cell; Motor Neurons; Myenteric Plexus; National Institute on Aging; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurochemistry; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropathy; Neurosciences; Nutrient; Nutrition; Nutritional Science; Organ; Pain; Painful; Pathology; Pattern; Phenotype; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Receptor Protein; Research; Resolution; Role; Science of neurochemistry; Science of nutrition; Senescence; Sensory; Sensory Cell Afferent Neuron; Specific qualifier value; Specified; Staining method; Stainings; Stains; Stomach; Subcellular Process; Submucosal Plexus; Submucous Plexus; Tag; Techniques; Testing; Therapeutic Intervention; To specify; Tracer; advanced age; age dependent; age effect; age related; age related neurodegeneration; aging effect; alimentary tract; axonopathy; base; bowel; cell motility; design; designing; digestive canal; digestive disorder; disease/disorder; elders; experiment; experimental research; experimental study; gastric; gastrointestinal; gastrointestinal disorder; geriatric; innervation; intervention therapy; interventional strategy; late life; later life; life span; lifespan; model organism; motoneuron; nerve supply; neural patterning; neurochemistry; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal patterning; neuropathic; nutrition; older adult; older person; programs; public health relevance; receptor; research study; senescent; senior citizen; social role; tool",Gastrointestinal Tract Innervation: Patterns of Aging,,61317,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",S1,7,98899,
8011277,R01,DK,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01DK061417-07S2,,NIDDK:101600;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"GEWIRTZ, ANDREW T;",1894094;,3R01DK061417,01/20/2010,12/31/2010,"Absorption; Affect; Apoptosis; Apoptosis Pathway; Bacteria; Categories; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chronic; Citrobacter; Closure by Ligation; Cytokines, Chemotactic; Developing Countries; Developing Nations; Disease; Disease Outbreaks; Disorder; Enteral; Enteric; Enteric Fever; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Extracellular Signal-Regulated Kinase Gene; Flagella; Flagellata; Flagellin; Gastroenteritis; Gene Expression; Gut Epithelium; Gut Inflammation; Health; Heterogeneity, Population; Homologous Chemotactic Cytokines; Host Defense Mechanism; Immune; Immune response; Infection; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Intercrines; Intestinal; Intestinal Inflammation; Intestines; Intracellular Communication and Signaling; Knowledge; Less-Developed Countries; Less-Developed Nations; Life; Ligation; MAP Kinase Gene; MAPK; Mammals, Mice; Mastigophora; Measures; Mediating; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Murine; Mus; Nutrient; Outbreaks; Outcome; Pathogenesis; Phenotype; Play; Population Heterogeneity; Process; Process of absorption; Proteins; Receptor Protein; Recruitment Activity; Research; Resistance; Role; S. typhimurium; S.typhimurium; SIS cytokines; Salmonella; Salmonella typhimurium; Series; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Structure of intestinal epithelium; Surface; Systemic infection; TIL3; TLR5; TLR5 receptor; Third-World Countries; Third-World Nations; Toll-Like Receptor 5; Toll/Interleukin-1 Receptor-Like Protein 3; Typhoid; Typhoid Fever; Typhoids; Typhus, Abdominal; Under-Developed Countries; Under-Developed Nations; absorption; biological signal transduction; bowel; chemoattractant cytokine; chemokine; commensal bacteria; commensal microbes; design; designing; disease/disorder; diverse populations; experiment; experimental research; experimental study; flagellate; food born pathogen; food borne pathogen; foodborn pathogen; foodborne pathogen; gastrointestinal epithelium; gene product; heterogeneous population; host response; human disease; immunoresponse; in vitro Model; in vivo; insight; intestinal epithelium; microbial; monomer; mouse model; pathogen; pathogenic bacteria; prevent; preventing; public health relevance; receptor; recruit; research study; resistant; response; social role; toll-5 receptor; trafficking",Flagellin-Induced Gut Epithelial Chemokine Secretion,,61417,HIBP,Host Interactions with Bacterial Pathogens Study Section,S2,7,101600,
8004278,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK061618-08S1,,NIDDK:68796;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"SALTIEL, ALAN R.;",1877632;,3R01DK061618,01/15/2010,03/31/2010,"Adipocytes; Adipose Cell; Assay; Attention; Attenuated; Autoregulation; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Process; Biologic Assays; Biological Assay; CDC42 Homolog Gene; CDC42-Interacting Protein Gene; CIP4; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chemotherapy-Hormones/Steroids; Chimera; Chimera organism; Cytoplasm; Cytoplasmic Membrane; D-Glucose; Data; Defect; Development; Dextrose; Diabetes Mellitus; Diet; Disease; Disorder; Endocrine Gland Secretion; Epidemic; Evaluation; Event; Exposure to; Family; Family member; Fat Cells; Fats; Fatty acid glycerol esters; Funding; Future; G-Proteins; G25K Gene; GAP Proteins; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GP Gene; GTP GDP exchange factor; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPase-Activating Proteins; Gene Deletion; Glucose; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Regulatory Proteins; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Heart; Homeostasis; Hormones; Humulin R; Hydrolysis; INSR; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Resistance; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Investigation; Isoforms; Knockout Mice; Laboratories; Learning; Lipids; Lipocytes; Location; Mammals, Mice; Mature Lipocyte; Mature fat cell; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; Muscle; Muscle Tissue; Names; Novolin R; Nucleotides; Null Mouse; Pathway interactions; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Primary Lesion; Process; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Recruitment Activity; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Specificity; Staging; Structure; Subcellular Process; TRIP10; TRIP10 gene; Therapeutic Hormone; Thyroid Hormone Receptor Interactor 10 Gene; Tyrosine Phosphorylation; Uncertainty; adapter protein; base; biological signal transduction; diabetes; disease/disorder; doubt; exchange factor; fat metabolism; gene deletion mutation; gene product; glucose transport; glucose uptake; guanosinetriphosphatase activating protein; in vitro Assay; insulin resistant; knock-down; lipid metabolism; mutant; novel; pathway; plasmalemma; recruit; rho; social role; trafficking; trait; uptake",The Role of G Proteins in Insulin Action,,61618,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,8,68796,
8012240,R01,DK,3,Y,02/01/2010,04/30/2010,PAS-07-267,3R01DK062027-07S1,,NIDDK:95655;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"HAMMER, GARY D;",1892284;,3R01DK062027,02/01/2010,04/30/2010,"ACTH; ACTH (1-39); AD4BP protein; ADRGND; Activities of Daily Living; Activities of everyday life; Ad4-binding protein; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Disorder; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Anaplastic; CAPS; Cancers; Capsules; Cell Cycle; Cell Division Cycle; Cells; Cellular biology; Chemotherapy-Hormones/Steroids; Cortex of adrenal gland; Corticotropin; Corticotropin (1-39); Data; Disease; Disorder; Endocrine Gland Secretion; FTZF1 protein; Fushi tarazu factor homolog 1; Future; Gene Targeting; Generalized Growth; Genes; Genomics; Growth; Hormones; Laboratories; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Molecular; Mother Cells; NR5A1 protein; Organ failure; Pathway interactions; Population; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Property; Property, LOINC Axis 2; Regulation; Role; SF 1; SF-1 transcription factor; SF1; Signal Pathway; Stem cells; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic; Therapeutic Hormone; Tissue Growth; Undifferentiated; abstracting; adrenal 4 binding protein; adrenal disorder; base; capsule (pharmacologic); cell biology; daily living functionality; disease/disorder; functional ability; functional capacity; in vivo; malignancy; mouse model; neoplasm/cancer; novel; nuclear receptor 5A1 protein; ontogeny; pathway; programs; response; self-renewal; social role; stem; stem cell niche; steroid hormone receptor Ad4BP; steroidogenic factor 1; suprarenal gland; transcription factor; transcription factor sf1",Mechanisms of Adrenal Differentiation," NARRATIVE Most hormone disorders of the adrenal cortical occur in the context of organ failure or overgrowth. Increasing evidence indicates that the cortex constantly renews its cell population through the constant proliferation of uncommitted cells lying in and/or underneath the outer capsule. Using cellular systems, mouse models together with genomic approaches, we aim to characterize the stem/progenitor cells of the adrenal cortex and uncover the mechanisms by which these cells are regulated by SF1 in normal adrenal growth maintenance. Future efforts are predicted to focus on therapies that target this pathway and downstream genes that are found in the course of these studies to participate in adrenocortical stem/progenitor cell biology.",62027,MCE,Molecular and Cellular Endocrinology Study Section,S1,7,95655,
8010772,R01,DK,3,Y,01/25/2010,12/31/2010,,3R01DK062039-07S1,,NIDDK:84105;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW HAVEN,UNITED STATES,PEDIATRICS,03,043207562,US,CT,065208047,YALE UNIVERSITY,"GALLAGHER, PATRICK G;",1905545;,3R01DK062039,01/25/2010,12/31/2010,"1H-Purin-6-amine; 2-Amino-6-Hydroxypurine; 6H-Purin-6-one, 2-amino-1,7-dihydro-; Adenine; Amino Acid Sequence; Anemia; Anemia, Hemolytic; Ankyrins; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Base Sequence; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biotechnology, Genetic Engineering; Blood erythrocyte; Blood normocyte; Body Tissues; Boundary Elements; CCCTC-binding factor; CHIP assay; CTCF protein; Cardiac; Cell membrane; Cells; Cerebellum; ChIP (chromatin immunoprecipitation); Characteristics; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Cis-Acting Locus; Cis-Acting Sequence; Closure by Ligation; Code; Coding System; Complementary DNA; Congenital Anomalies, Nervous System; Congenital neurologic anomalies; Cytoplasmic Membrane; DNA; DNA Alteration; DNA Molecular Biology; DNA mutation; DNA, Complementary; DNA-binding protein CTCF; DNase; Data; Defect; Deoxyribonucleases; Deoxyribonucleic Acid; Dependence; Development; Diagnosis; Disease; Disorder; EKLF; ERYF1; ERYF1 protein, human; Electrophoretic Mobility Shift Assay; Elements, Boundary; Erythrocyte Cytoskeleton; Erythrocyte Membrane; Erythrocytes; Erythrocytic; Erythroid; Erythroid Cells; Erythroid Transcription Factor; Erythropoiesis; Exhibits; Exons; GATA Binding Protein 1; GATA binding protein 1, human; GATA-1; GATA1; GATA1 protein, human; GF1; Gene Alteration; Gene Expression; Gene Mutation; Gene Organization; Gene Proteins; Gene Structure; Gene Structure/Organization; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Engineering; Genetic Intervention; Genetic defect; Genetic mutation; Genomics; Goals; Guanine; HPLC; Hemolytic Anemia; Hereditary; Hereditary Spherocytosis; High Pressure Liquid Chromatography; Human; Human, General; Inherited; Intervention, Genetic; Investigators; Isoforms; L-Methionine; Ligation; Link; Man (Taxonomy); Man, Modern; Maps; Marrow erythrocyte; Mediating; Membrane Proteins; Membrane-Associated Proteins; Messenger RNA; Methionine; Methionine, L-Isomer; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Methylation; Mice, Transgenic; Minkowski Chauffard syndrome; Mobility Shift Assay; Molecular; Molecular Biology; Molecular Biology, Gene Therapy; Molecular Biology, Genetic Engineering; Molecular Biology, Protein Sequencing; Molecular Genetic; Molecular Genetics; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Mutation; Myocytes; N-terminal; NFE1; NH2-terminal; Nerve Cells; Nerve Unit; Nervous; Nervous System Abnormalities; Nervous System Anomalies; Nervous System Congenital Abnormalities; Nervous System Congenital Malformations; Nervous System Malformations; Neural Cell; Neurocyte; Neurons; Nucleases, DNA; Nucleotide Sequence; Pathogenesis; Patients; Pattern; Peptide Sequence Determination; Plasma Membrane; Play; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Gene Products; Protein Isoforms; Protein Methylation; Protein Sequencing; Protein Structure, Primary; RNA, Messenger; Recombinant DNA Technology; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Regulatory Element; RegulatoryElement; Reporter Genes; Reporting; Research; Research Personnel; Researchers; Reticuloendothelial System, Erythrocytes; Role; SEQ-AN; Sequence Alteration; Sequence Analyses; Sequence Analysis; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Site; Spherocytosis, Hereditary; Staging; Structure; Surface Proteins; Techniques; Therapy, DNA; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Transcript; Transcription Factor GATA1; Transgenic Mice; Vitamin B4; Work; anemia spherocytic; blood corpuscles; cDNA; cell type; chromatin immunoprecipitation; congenital nervous system disorder; dimethyl sulfate; dimethylsulfate; disease/disorder; erythroid Kruppel-like factor; erythrold transcription factor 1; gel shift assay; gene function; gene therapy; genetic therapy; genome mutation; globin transcription factor 1; globin transcription factor 1, human; human GATA1 protein; human disease; in vivo; insight; mRNA; membrane skeleton; neural; neuronal; novel; nucleic acid sequence; plasmalemma; prevent; preventing; programs; protein sequence; relating to nervous system; social role; tissue/cell culture; tool; trans acting factor (genetic); transcription factor; transfer of a gene",Molecular Biology of Erythrocyte Ankyrin,,62039,ZRG1,Special Emphasis Panel,S1,7,84105,
7994605,R01,DK,3,Y,01/15/2010,09/30/2010,,3R01DK062348-07S1,,NIDDK:53158;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"AHIMA, REXFORD S;",6461704;,3R01DK062348,01/15/2010,09/30/2010,"ACTH-Releasing Factor; AMP Kinase; ATP-AMP Phosphotransferase; ATP-AMP Transphosphorylase; Adenylokinase; Adipose tissue; Adverse effects; Agonist; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Anorectic Drug; Anorectic agent; Anorectics; Anorexiant; Anorexic Drugs; Anorexient Agent; Anorexient Drug; Anorexigenic Drugs; Apnea, Sleep; Appetite; Appetite Depressants; Appetite Suppressants; Appetite-Depressing Drugs; Appetite-Suppressant Drugs; Applications Grants; Area; Arthritis; Attenuated; Autoregulation; Binding; Binding (Molecular Function); Body Weight decreased; Brain; CRF-41; CRH; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cholelithiasis; Common Rat Strains; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; D-Glucose; Data; Desire for food; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Drugs; Dysfunction; EC 2.3.1.85; Eating; Eels, Lamprey; Encephalon; Encephalons; Energy Expenditure; Energy Metabolism; Enzymes; Epidemic; Excess Mortality; FLR; Failure (biologic function); Fatty Acid Synthetase Complex; Fatty Liver; Fatty Tissue; Fatty-acid synthase; Food Intake; Functional disorder; Gallbladder Calculus; Gallbladder Stone; Gallstones; Genetic; Glucose; Goals; Grant; Grant Proposals; Grants, Applications; Heat Production; Hepatic Disorder; Homeostasis; Humulin R; Hyperlipemia; Hyperlipidemia; Hypothalamic structure; Hypothalamus; Incidence; Injection of therapeutic agent; Injections; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Lampreys; Lateral; Leptin; Life; Life Style; Lifestyle; Link; Lipids; Lipolysis; Liver; Liver Steatosis; Liver diseases; MC4 Receptor; METBL; MODY; MSI 1436; MSI1436; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Maturity-Onset Diabetes Mellitus; Mediating; Medication; Melanocortin 4 Receptor; Membrane; Membrane Channels; Metabolic; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Obese; Molecular Interaction; Murine; Mus; Muscle; Muscle Tissue; Myokinase; NAFLD; NASH; NIDDM; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptide Tyrosine; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-alcoholic steatohepatitis; Novolin R; Nucleus; Nucleus Tractus Solitarii; Nucleus solitarius; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Mice; Obese Protein; Obesity; Obesity associated disease; Obesity related disease; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathway interactions; Patients; Peptides; Peripheral; Petromyzontidae; Pharmaceutic Preparations; Pharmaceutical Preparations; Pheromone; Physiological Homeostasis; Physiopathology; Property; Property, LOINC Axis 2; Rat; Rattus; Receptor Gene; Receptor Protein; Receptor Signaling; Receptor, Melanocortin, Type 4; Risk; Rodent; Rodentia; Rodentias; Role; SHU 9119; SHU9119; Signal Transduction; Signal Transduction Systems; Signaling; Sleep Apnea Syndromes; Sleep Hypopnea; Sleep-Disordered Breathing; Solitary Nucleus; Starvation; Steroid Compound; Steroids; Structure of paraventricular nucleus; Surface; System; System, LOINC Axis 4; T2D; T2DM; Thermogenesis; Treatment Side Effects; Triacylglycerol; Triglycerides; Type 2 diabetes; Type II diabetes; United States; Weight; Weight Loss; Weight Reduction; Xenopus oocyte; adenylate kinase; adipose; adiposity; adult onset diabetes; amygdaloid nuclear complex; anorexic agent; arthritic; biological signal transduction; body system, hepatic; body weight loss; cardiovascular disorder; cholelith; corpulence; corpulency; corpulentia; corticotropin releasing hormone; db/db mouse; diabetes; diet and exercise; drug/agent; energy balance; failure; fat metabolism; fatty acid oxidation; feeding; food consumption; hepatic steatosis; hepatopathy; hypothalamic; immunoreactivity; improved; in vivo; insight; insulin sensitivity; insulin signaling; intraperitoneal; ketosis resistant diabetes; lipid metabolism; liver disorder; malignancy; maturity onset diabetes; membrane structure; neoplasm/cancer; neuronal; neuropeptide Y; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; novel; ob/ob mouse; obese; obese people; obese person; obese population; obesity treatment; organ system, hepatic; paraventricular nucleus; pathophysiology; pathway; prevent; preventing; receptor; reproductive; response; sedentary; side effect; social role; solitary tract nucleus; therapy adverse effect; treatment adverse effect; white adipose tissue; wt-loss; yellow adipose tissue",CNS action of appetite suppressant aminosterol,,62348,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,7,53158,
7998790,R01,DK,3,,02/01/2010,05/31/2010,PA-07-070,3R01DK064213-06A1S1,,NIDDK:32670;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"LIDDLE, RODGER A.;",1881326;,3R01DK064213,04/01/2003,05/31/2014,"6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))-; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-; 8-Methyl-N-Vanillyl-6-Nonenamide; Absolute ethanol; Acids; Acute; Afferent Neurons; Alcohol, Ethyl; Alcohols; Amino Acids; Animal Model; Animal Models and Related Studies; Arachidonic Acids; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Assay; Bears; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Body Temperature; Body Tissues; Bradykinin; CGRP; Cachectin; Cachectin-Tumor Necrosis Factor; Caerulein; Calcitonin Gene-Related Peptide; Capsaicin; Categories; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Ceruletid; Ceruletide; Cessation of life; Chemical Class, Alcohol; Cholelithiasis; Complex; Data; Death; Disease; Disorder; Dorsal Horn of the Spinal Cord; Dorsal Root Ganglia; Dropsy; ETOH; Edema; Endocytosis; Esteroproteases; Ethanol; Euler-Gaddum Substance P; Event; Evolution; Extravasation; Family; Fiber; Funding; Gallbladder Calculus; Gallbladder Stone; Gallstones; Ganglia, Spinal; Gastrointestinal Tract, Pancreas; Generations; Genetic; Gland; Goals; Grain Alcohol; H+ element; Heating; Hydrogen Ions; Hydrops; INFLM; Inflammation; Inflammation Mediators; Inflammatory; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; LTB4; Lead; Leakage; Leukotriene B-4; Leukotriene B4; Leukotrienes; Mammals, Mice; Measures; Mediating; Methylcarbinol; Mice; Modeling; Molecular; Murine; Mus; NK-1 Receptors; NK1R; NKIR; Nerve; Nervous; Neurogenic Inflammation; Neurons, Afferent; Neurons, Sensory; Neuropeptides; Nociception; Organ System; Pain; Painful; Pancreas; Pancreatic; Pancreatic Injury; Pancreatic Trauma; Pancreatic enzyme; Pancreatitis; Pathogenesis; Pb element; Peptidases; Peptide Hydrolases; Plasma; Play; Position; Positioning Attribute; Predisposing Factor; Process; Proteases; Proteinases; Proteolytic Enzymes; Protons; Receptor Protein; Receptors, Neurokinin-1; Relative; Relative (related person); Research Resources; Resources; Reticuloendothelial System, Serum, Plasma; Rodent Model; Role; SP(1-11); SP-P Receptors; Sensory; Sensory Cell Afferent Neuron; Sensory Nerve Endings; Serum, Plasma; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Spillage; Spinal Ganglia; Spinal cord posterior horn; Stiefel Brand of Capsaicin; Stimulus; Substance P; Substance P Receptor; TAC1R; TACR1; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Tachykinin; Tachykinin Receptor 1; Testing; Tissues; Tripcellim; Trypsin; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Ursidae; Ursidae Family; VR1 receptor; Vanilloid; Vascular Permeabilities; Vasodilatation; Vasodilation; Vasorelaxation; Viscera; acute pancreatitis; afferent nerve; aminoacid; biological signal transduction; body system; capsaicin receptor; cell body (neuron); cholelith; chronic pancreatitis; design; designing; disease/disorder; dorsal root ganglion; heavy metal Pb; heavy metal lead; improved; in vivo; innervation; intense pain; kallidin 9; kallidin I; model organism; nerve supply; neural cell body; neural mechanism; neurokinin 1; neuromechanism; neuronal cell body; nociceptive; novel; pancreas enzyme; premature; public health relevance; receptor; recurrent pancreatitis; sensory nerve; social role; soma; tool; treatment strategy; tumor necrosis factor (unspecified); vanilloid receptor VR1; vanilloid receptors",Pathogenic Mechanisms of Pancreatitis," Pancreatitis is an inflammatory disease of the pancreas that causes intense pain and, in severe cases, death. Although some predisposing factors (such as gallstones and alcohol) are known, the exact mechanisms leading to pancreatitis are not well understood. Pain-sensing nerves release transmitters that may actually cause inflammation and preliminary data indicate that these nerves play a role in pancreatitis. This proposal will characterize the neural mechanisms that contribute to pancreatitis and may lead to improved treatments of the disease.",64213,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,A1S1,6,32670,
8012055,R01,DK,3,Y,02/01/2010,12/31/2010,,3R01DK064223-05S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GLENN, JEFFREY S;",1929609;,3R01DK064223,02/01/2010,12/31/2010,"Affect; Affinity; Amino Acids; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Cell Extracts; Cell membrane; Cells; Clinical; Complement; Complement Proteins; Complex; Cytoplasmic Membrane; Dependence; Elements; Esteroproteases; Face; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Genotype; HCV; HCV infection; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Hydrophobic Surfaces; Immune Precipitation; Immunoprecipitation; In Vitro; Individual; Infection; Knowledge; Label; Lead; Length; Life Cycle; Life Cycle Stages; Ligands; Link; Lipids; Liposomal; Liposomes; Location; Maintenance; Maintenances; Mediating; Membrane; Methods; Modification; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Molecular Interaction; Molecular Virology; Mutagenesis; Mutate; Mutation; N-terminal; NANBH; NH2-terminal; Nature; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Pb element; Peptidases; Peptide Hydrolases; Peptides; Phage Display; Plasma Membrane; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; RNA Viruses; RNA replication; RNA, Viral; Replication Unit; Replicon; Role; Structural Protein; Structure; Surface; TM Domain; Testing; Translating; Translatings; Transmembrane Domain; Transmembrane Region; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Viral hepatitis; Virus; Virus Replication; Viruses, General; alpha helix; aminoacid; anti-hepatitis C; base; combat; design; designing; effective therapy; experiment; experimental research; experimental study; facial; gene product; genome mutation; heavy metal Pb; heavy metal lead; hepatitis non A non B; hepatitis nonA nonB; in vivo; language translation; life course; membrane structure; mutant; new approaches; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; novel approaches; novel strategies; novel strategy; plasmalemma; programs; replicase; research study; social role; translation assay; viral RNA; virus RNA; virus multiplication; virus protein",HCV NS5A: Molecular Virology and Antiviral Target,,64223,EVR,Experimental Virology Study Section,S1,5,100000,
7993160,R01,DK,3,Y,01/13/2010,03/31/2010,,3R01DK064646-07S2,,NIDDK:8234;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,PEDIATRICS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HUSSAIN, MEHBOOB A;",7335602;,3R01DK064646,01/13/2010,03/31/2010,"Bone Marrow; Cells; Endocrine; Gastrointestinal Tract, Pancreas; Natural regeneration; Pancreas; Pancreatic; Regeneration; Reticuloendothelial System, Bone Marrow; regenerate",Endocrine pancreatic cell regeneration from bone marrow,,64646,MET,Metabolism Study Section,S2,7,8234,
8009210,R01,DK,3,Y,02/01/2010,06/30/2010,PA-07-070,3R01DK064678-06S1,,NIDDK:82900;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"LEE, JAE W;",7342844;,3R01DK064678,02/01/2010,06/30/2010,"Address; Animals; Area; Autoregulation; Biochemical; Biochemical Pathway; CHIP assay; ChIP (chromatin immunoprecipitation); Chromatin; Code; Coding System; Complex; Drugs; EC 2.1.1; Energy Expenditure; Energy Metabolism; Enzymes; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genetic; Genetic Transcription; Goals; Hepatic; Histone Acetylation; Histone H3; Homeostasis; Intermediary Metabolism; L-Lysine; Lead; Lipids; Liver; Lysine; METBL; Mammals, Mice; Mediating; Medication; Metabolic; Metabolic Control; Metabolic Networks; Metabolic Processes; Metabolic syndrome; Metabolism; Methylation; Methyltransferase; Mice; Mice, Mutant Strains; Molecular; Murine; Mus; Mutant Strains Mice; Nuclear Receptors; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Play; Protein Methylation; RNA Expression; Receptor Protein; Receptor Signaling; Regulation; Reporter; Role; Trans-Activation (Genetics); Transactivation; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Work; base; blood glucose regulation; body system, hepatic; chromatin immunoprecipitation; demethylation; design; designing; drug/agent; experiment; experimental research; experimental study; fight against; glucose control; glucose homeostasis; glucose metabolism; glucose regulation; heavy metal Pb; heavy metal lead; in vivo; methylase; mouse mutant; mutant; novel; organ system, hepatic; pandemic; pandemic disease; paralog; paralogous gene; public health relevance; receptor; research study; social role; transmethylase",MLL3/4-complexes in nuclear receptor-mediated metabolism," Project Narrative We found that ASCOM plays central roles in a complex network of metabolic gene regulation by nuclear receptors. Thus, this study of ASCOM will directly contribute to our understanding of metabolic control by nuclear receptors. Moreover, this study can be directly applied to designing proper strategies to fight against the metabolic syndrome, a growing pandemic, because ASCOM has two distinct classes of chemically amenable enzymes.",64678,MCE,Molecular and Cellular Endocrinology Study Section,S1,6,82900,
8010462,R01,DK,3,Y,01/14/2010,04/30/2010,,3R01DK064938-04S1,,NIDDK:89185;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,COLUMBUS,UNITED STATES,BIOCHEMISTRY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"HAI, TSONWIN ;",1876375;,3R01DK064938,01/14/2010,04/30/2010,"APO-1 Antigen; APO-1 Cell Surface Antigen; Address; After Care; After-Treatment; Aftercare; Allogenic; Antibodies; Apoptosis; Apoptosis Antigen 1; Apoptosis Pathway; Apoptotic; Assay; B blood cells; B-Cells; B-Lymphocytes; Bioassay; Biologic Assays; Biological Assay; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CAP4 protease; CASP8 Protein; CD95 Antigens; CD95 molecule; Cachectin Receptors; Caspase-8/Flice; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cells; Cessation of life; Clinical; Complementary DNA; DNA; DNA, Complementary; Data; Death; Deoxyribonucleic Acid; Development; Diabetes Mellitus; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Engineering; Engineerings; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Gene Expression; Gene Inactivation; Gene Silencing; Gene Targeting; Genes; Goals; Graft Rejection; Graft Survival; Grafting, Islets of Langerhans; Humulin R; Immune; Immunity; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Investigators; Islets of Langerhans Transplantation; Knock-out; Knockout; Knockout Mice; Letters; MACH protein; Mch5 protease; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Modeling; Mononitrogen Monoxide; Natural immunosuppression; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Novolin R; Nucleotides; Null Mouse; Pathway interactions; Peptides; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protocol; Protocols documentation; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Receptor Protein; Research; Research Personnel; Researchers; Resistance; Role; Sequence-Specific Posttranscriptional Gene Silencing; Stress; Symptoms; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; TNFRSF6 Receptor; Targetings, Gene; Technology; Testing; Transgenic Mice; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor Receptor Superfamily, Member 6; Universities; Urd; Uridine; Work; cDNA; caspase-8; cytokine; diabetes; diabetic; diabetic patient; endothelial cell derived relaxing factor; fas Antigens; fas Receptors; immunosuppression; improved; inhibitor; inhibitor/antagonist; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet transplantation; knock-down; mRNA; mitochondrial; necrocytosis; non-diabetic; nondiabetic; pathway; prevent; preventing; programs; receptor; resistant; response; shRNA; short hairpin RNA; small hairpin RNA; social role; stem; transplant",ATF3 and iNOS in Islet Distruction and Graft Rejection,,64938,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,4,89185,
8010997,R01,DK,3,Y,02/01/2010,04/30/2010,PA-02-161,3R01DK065131-05S1,,NIDDK:18000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"GANNON, MAUREEN A;",1975002;,3R01DK065131,02/01/2010,04/30/2010,"Abnormal Cell; Affect; Alleles; Allelomorphs; Anaplastic; Architecture; B9 endocrine pancreas; Birth; Cell Lineage; Cells; Characteristics; Data; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Duct; Duct (organ) structure; ES cell; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endocrine; Engineering / Architecture; Epithelium; Event; Expression Profiling; Expression Signature; Gastrointestinal Tract, Pancreas; Generations; Genes; Goals; Grafting, Islets of Langerhans; Humulin R; Hyperplasia; Hyperplastic; IDD; IDDM; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Islands of Langerhans; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Knock-out; Knockout; Location; Lymphocytes, Null; Mammals, Mice; Mice; Mice, Mutant Strains; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutant Strains Mice; Nesidioblasts; Novolin R; Null Cells; Null Lymphocytes; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Parturition; Pathway interactions; Phenotype; Play; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Research; Role; Series; Staging; T1 diabetes; T1D; T1DM; Testing; Time; Tissue Donors; Transgenes; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 1 diabetes; Undifferentiated; Work; base; beta cell development; cell type; diabetes; diabetic; early embryonic stage; embryonic stem cell; endocrine pancreas; endocrine pancreas development; in vivo; insulin dependent diabetes; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; molecuar profile; molecular signature; mouse mutant; mutant; pathway; progenitor; programs; recombinase; role model; social role; stem cell of embryonic origin; stem cell population; transcription factor; type I diabetes",HNF6 Function in the Pancreatic Endocrine Lineage,,65131,MET,Metabolism Study Section,S1,5,18000,
7998288,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK065900-08S1,,NIDDK:99210;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"SIMERLY, RICHARD B;",1886575;,3R01DK065900,01/15/2010,12/31/2010,"21+ years old; Address; Adipocytes; Adipose Cell; Adult; Architecture; Arcuate Nucleus; Assay; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Body Weight; Brain; Cell Communication and Signaling; Cell Signaling; Chemotherapy-Hormones/Steroids; Critical Period; Critical Period (Psychology); Development; Documentation; Eating; Effects, Longterm; Encephalon; Encephalons; Endocrine Gland Secretion; Energy Expenditure; Energy Metabolism; Engineering / Architecture; Environment; Exposure to; Fat Cells; Food Intake; Generalized Growth; Goals; Growth; Homeostasis; Hormones; Human, Adult; Hypothalamic structure; Hypothalamus; In Vitro; Infundibular Nucleus; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Knowledge; Leptin; Life; Lipocytes; Litter Size; Long-Term Effects; METBL; Malnutrition; Mammals, Mice; Mature Lipocyte; Mature fat cell; Measures; Mediating; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Murine; Mus; Neonatal; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Development; Neural Pathways; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Nodal; Nutrition; Nutritional; Nutritional Deficiency; Nutritional Science; Nutritional status; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Overnutrition; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathway interactions; Pattern; Peripheral; Physiologic; Physiological; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; Regulation; Research; Research Personnel; Researchers; Science of nutrition; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure of nucleus infundibularis hypothalami; Structure of paraventricular nucleus; Techniques; Testing; Therapeutic Hormone; Time; Tissue Growth; Undernutrition; adiposity; adult human (21+); biological signal transduction; corpulence; corpulency; corpulentia; critical developmental period; critical period; dietary deficiency; energy balance; feeding; gain of function; hypothalamic; in vivo; loss of function; mouse model; neural; neural circuit; neural circuitry; neurodevelopment; neuronal; nutrition; ob/ob mouse; obese; obese people; obese person; obese population; ontogeny; paraventricular nucleus; pathway; postnatal; programs; relating to nervous system",Development of Leptin-Sensitive Hypothalamic Pathways,,65900,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,8,99210,
7992510,R01,DK,3,Y,01/01/2010,03/31/2010,DK-03-008,3R01DK066369-05S1,,NIDDK:58000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"ATTIE, ALAN D;",1897611;,3R01DK066369,01/01/2010,03/31/2010,"Alleles; Allelomorphs; Animals; Attic; B9 endocrine pancreas; Beta Cell; Biochemical Pathway; Cells; Chromosome Mapping; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dimensions; Employee Strikes; Epitympanic Recess; Expression Profiling; Expression Signature; FLR; Failure (biologic function); Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Products, RNA; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Markers; Genetic defect; Genetics, Gene Mapping; Genotype; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Resistance; Insulin Secreting Cell; Insulin, Regular; Islands of Langerhans; Islet Cells; Islets of Langerhans; Leptin; Linkage Mapping; MODY; Mammals, Mice; Maps; Maturity-Onset Diabetes Mellitus; Messenger RNA; Metabolic Networks; Methods; Mice; Microarray Analysis; Microarray-Based Analysis; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutation; NIDDM; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Pancreas, Endocrine; Pancreatic Islets; Pancreatic beta Cell; Pars endocrina pancreatis; Persons; Phenotype; Population; Predisposition; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Recessus epitympanicus structure; Regulatory Pathway; Resolution; Ribonucleic Acid; Strikes; Strikes, Employee; Structure of beta Cell of islet; Susceptibility; T2D; T2DM; Technology; Type 2 diabetes; Type II diabetes; adiposity; adult onset diabetes; beta cell development; corpulence; corpulency; corpulentia; diabetes; endocrine pancreas; endocrine pancreas development; failure; genetic mapping; genome mutation; insulin resistant; islet; islet development; islet progenitor; ketosis resistant diabetes; mRNA; maturity onset diabetes; microarray technology; molecuar profile; molecular signature; novel; ob/ob mouse; obese; obese people; obese person; obese population; pancreas beta cell; positional cloning; reverse genetics; trait",Genetic Mapping / Beta-cell Decomposition in Type 2 Diabetes,,66369,ZRG1,Special Emphasis Panel,S1,5,58000,
8010995,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK066411-02S2,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,FARMINGTON,UNITED STATES,OTHER BASIC SCIENCES,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"ARNOLD, ANDREW ;",1939178;,3R01DK066411,02/01/2010,01/31/2011,"Address; Aging; American; Animals; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Benign; Biochemical; Biochemical Pathway; Biological Models; Blood Coagulation Factor IV; Blood Serum; CCND1 Protein; CDK; CDK4 Protein; Ca++ element; Calcium; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cancers; Cell Cycle; Cell Division Cycle; Cell Division Protein Kinase 4; Cellular Oncogene; Chronic; Coagulation Factor IV; Complex; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; Data; Derivation; Derivation procedure; Disease; Disorder; Endocrine Diseases; Endocrine Diseases and Manifestations; Endocrine System Diseases; Epidermoid Cell Cancer; Factor IV; First Gap Phase; G1 Phase; G1 period; G1/S-Specific Cyclin D1; Gap Phase 1; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Growth; Head and Neck, Parathyroid; Human; Human, General; Hyperparathyroidism; Malignant; Malignant - descriptor; Malignant Epidermoid Cell Neoplasm; Malignant Epidermoid Cell Tumor; Malignant Neoplasms; Malignant Squamous Cell Neoplasm; Malignant Squamous Cell Tumor; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic Networks; Mice; Mice, Transgenic; Model System; Models, Biologic; Molecular; Molecular Target; Multiple Myeloma; Murine; Mus; Mutation; Myeloma, Plasma-Cell; Neoplasms; Neuroblastoma of the Retina; Neuroblastoma, Retinal; Nutritional; Nutritional status; Oncogenes; Oncogenesis; Oncogenic; Osteoporosis; P105-RB; PP110; PRAD1 Protein; PSK-J3 kinase; PTH (1-84); PTH protein, human; Parathyroid; Parathyroid Adenoma; Parathyroid Gland Adenoma; Parathyroid Gland Neoplasm; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormones; Parathyroid Neoplasms; Parathyroid gland; Pathogenesis; Pathway interactions; Phenotype; Physiologic; Physiological; Process; Proteins; Proto-Oncogene Proteins c-bcl-1; Proto-Oncogenes; RB1; Rb Gene Product; Rb Protein; Rb1 Gene Product; Research; Research Design; Retinoblastoma; Retinoblastoma Associated Protein; Retinoblastoma Protein; Role; Senescence; Serum; Squamous Cell Cancers; Study Type; System; System, LOINC Axis 4; Testing; Tissue Growth; Transforming Genes; Transgenes; Transgenic Mice; Tumor of the Parathyroid; Tumor of the Parathyroid Gland; Tumorigenicity; Tumors; VIT D; Vitamin D; Vitamin D Deficiency; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; c-ONC; c-bcl-1 Proteins; cdk Proteins; cdk4 cyclin-dependent kinase; cyclin D; cyclin D-dependent kinase CDK4; disease/disorder; endocrine disorder; gene product; genome mutation; hPTH(1-84); human PTH protein; in vivo; inhibitor; inhibitor/antagonist; insight; malignancy; malignant breast neoplasm; mutant; myeloma; myelomatosis; neoplasia; neoplasm/cancer; neoplastic; neoplastic growth; novel; ontogeny; overexpression; p34(cdk4); p34PSK-J3 kinase; p34PSK-J3-CDK4 kinase; pRB; parathormone; parathyroid hormone, human; pathway; protooncogene; senescent; social role; study design; treatment strategy; tumor; tumorigenesis",MOLECULAR PATHOGENESIS OF HYPERPARATHYROIDISM,,66411,SBDD,Skeletal Biology Development and Disease Study Section,S2,2,100000,
8004316,R01,DK,3,Y,01/15/2010,03/31/2011,,3R01DK066485-04S1,,NIDDK:81126;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PORTLAND,UNITED STATES,NEUROSCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"SHYNG, SHOW-LING ;",1890083;,3R01DK066485,01/15/2010,03/31/2011,"ADP, Magnesium; ATP sensitive potassium channel; ATP sensitive potassium channel complex; Address; Adenosine Triphosphate, Magnesium Salt; Adenoviridae; Adenoviruses; Affect; Assay; Binding; Binding (Molecular Function); Bioassay; Biogenesis; Biologic Assays; Biological Assay; Blood Plasma; Blood Vessels; COS Cells; COS-1; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell membrane; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Common Rat Strains; Complex; Congenital Hyperinsulinism; Congenital hyperinsulinemia; Coupling; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; D-Glucose; Data; Defect; Dextrose; Diabetes Mellitus; Diabetes mellitus syndrome in newborn infant; Disease; Disorder; Dysfunction; Endocrine Gland Secretion; Family; Functional disorder; GIRK1; GIRK1 subunit, G protein-coupled inwardly-rectifying potassium channel; Gastrointestinal Tract, Pancreas; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Glucose; Goals; Hand; Health; Homology Modeling; Hormones; Human; Human, General; Hyperinsulinemia Hypoglycemia of Infancy; Hypoglycemia; Hypoglycemia of Infancy; I(KACh) subunit GIRK1; IRK1 channel; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intermediary Metabolism; Internet; Intracellular Communication and Signaling; Investigators; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; Ions; Ischemia; K element; K+ Channels, Inwardly Rectifying; KCNJ3; KCNJ3 channel; Kir3.1 potassium channel; Knowledge; Lead; Ligand Binding; METBL; Magnesium Adenosine Triphosphate; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Potentials; Metabolic Processes; Metabolism; MgADP; MgATP; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Monitor; Muscle, Cardiac; Muscle, Heart; Mutagenesis; Mutate; Mutation; Myocardium; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Organism-Level Process; Organismal Process; Origin of Life; PHHI Hypoglycemia; Pancreas; Pancreatic; Patients; Pb element; Persistent Hyperinsulinemia Hypoglycemia of Infancy; Pharmacological Treatment; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Physiopathology; Plasma; Plasma Membrane; Play; Population; Potassium; Potassium Channels, Inwardly Rectifying; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; PtdIns; Rat; Rattus; Recombinants; Regulation; Research; Research Personnel; Researchers; Rest; Resting Potentials; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Site; Structure; Structure-Activity Relationship; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Hormone; Transmembrane Potentials; WWW; Work; base; biological signal transduction; cardiac muscle; cell type; chemical structure function; cultured cell line; design; designing; diabetes; disease-causing mutation; disease/disorder; drug development; gain of function mutation; gene product; genome mutation; glucose sensor; heart muscle; heavy metal Pb; heavy metal lead; hypoglycemic; hypoglycemic episodes; insight; insulin secretion; inward rectifier potassium channel; loss of function; loss of function mutation; member; membrane structure; mutant; neonatal diabetes; neonatal diabetes mellitus; neuronal; novel; pathophysiology; plasmalemma; programs; protein expression; protein protein interaction; response; social role; structure function relationship; sulfonylurea receptor; vascular; web; world wide web",Structural Basis of Katp Channel Gating,,66485,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",S1,4,81126,
7998421,R01,DK,3,Y,01/03/2010,12/31/2010,PA-07-070,3R01DK066604-05A1S1,,NIDDK:196041;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LOW, MALCOLM JAMES;",1900352;,3R01DK066604,01/03/2010,12/31/2010,"21+ years old; ACTH-beta-Lipotropin Precursor; Adenoviral Vector; Adenovirus Vector; Adult; Age; Alleles; Allelomorphs; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Appetite; Arcuate Nucleus; Area; Automobile Driving; Autoregulation; Axon; Basal Metabolism; Basal metabolic rate; Bed Nucleus of Stria Terminalis; Behavioral; Body Weight; Brain; Brain Stem; Brainstem; Canine Species; Canis familiaris; Cell Body; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell/Tissue, Immunohistochemistry; Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Clinical; Complex; Controlled Study; Corticotropin-beta-Lipotropin Precursor; Dendrites; Desire for food; Development; Diabetes Mellitus; Distal; Dogs; Drivings, Automobile; Drug Therapy; Encephalon; Encephalons; Endorphin-ACTH Precursor; Enhancers; Epidemic; Equilibrium; Feeding behaviors; Food; Food Intake Regulation; Fore-Brain; Forebrain; Fusion Protein; Gene Expression; Genes; Genetic; Genetic Techniques; Goals; Health; Homeostasis; Human; Human, Adult; Human, General; Hyperphagia; Hypothalamic structure; Hypothalamus; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Infundibular Nucleus; Ingestive Behavior; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Label; Mammals, Dogs; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Microinjections; Molecular; Morula; Motor; Murine; Mus; Mutant Strains Mice; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Pathways; Neurochemistry; Neurocyte; Neurologic; Neurological; Neurons; Neurotransmitters; Nucleus; Nucleus Accumbens; Obesity; Output; Over weight; Overeating; Overweight; POMC; Pathogenesis; Pathway interactions; Pattern; Pharmacotherapy; Physiologic; Physiological; Physiological Homeostasis; Physiology; Play; Prevention; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Pro-Opiomelanocortin; Process; Proopiocortin; Proopiomelanocortin; Prosencephalon; Public Health; Rewards; Role; Science of neurochemistry; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stereotyping; Stria Terminalis Nucleus; Structure of nucleus infundibularis hypothalami; Structure of terminal stria nuclei of preoptic region; Synapses; Synaptic; System; System, LOINC Axis 4; Technics, Genetic; Techniques; Testing; Thesaurismosis; Transgenes; Transgenic Organisms; Triticum Vulgare Lectins; Viral Vector; Weaning; Wheat Germ Agglutinins; Wheat Germ Lectins; adeno vector; adenovector; adiposity; adult human (21+); amygdaloid nuclear complex; balance; balance function; base; biological signal transduction; canine; cell body (neuron); corpulence; corpulency; corpulentia; diabetes; domestic dog; driving; energy balance; experiment; experimental research; experimental study; feeding; feeding-related behaviors; hedonic; hypothalamic; innervation; melanocortin receptor; metabolism disorder; mouse model; mouse mutant; nerve supply; neural; neural cell body; neural circuit; neural circuitry; neurochemistry; neuronal; neuronal cell body; novel; nutrient intake activity; obese; obese people; obese person; obese population; pathway; polyphagia; prevent; preventing; psychologic; psychological; public health medicine (field); public health relevance; recombinase; relating to nervous system; research study; resting metabolic rate; social role; soma; stereotypy; transgenic",Neurochemistry/Physiology of Proopiomelanocortin Neurons," Project Narrative Among the greatest current threats to public health are the continually increasing rates of overweight, obesity, diabetes, and the metabolic syndrome. A complex set of neural circuits integrates the balance between caloric demand and utilization with the behavioral and psychological processes related to feeding. This project centers on a key component of the brain's feeding circuits, propiomelanocortin neurons, to explain how these neurons coordinately regulate appetite, meal initiation and termination, and metabolic rate to normally maintain body weight within tightly controlled limits.",66604,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,A1S1,5,196041,
7994250,R01,DK,3,Y,01/15/2010,12/31/2010,DK-03-011,3R01DK066840-05S2,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"BERETTA, LAURA ;",6629601;,3R01DK066840,01/15/2010,12/31/2010,"2D PAGE; ATGN; Affinity; Antibodies; Antigens; Appearance; Autoantibodies; Blood Serum; Blood Tests; Blotting, Western; Body Tissues; Cancer Screening for Patients; Cancers; Carcinoma; Carcinoma of the Liver Cells; Causality; Chronic Hepatitis C; Chronic type C viral hepatitis; Chronic viral hepatitis C; Cirrhosis; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Detection; Development; Diagnosis; Director's Challenge; Director's Challenge[{..}] Towards a Molecular Classification of Tumors; Early Diagnosis; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Etiology; Europe; Expression Profiling; Expression Signature; Extraordinary Opportunities[{..}] the Director's Challenge[{..}] Toward a Molecular Classification of Tumors; Extraordinary Opportunity[{..}] Defining the Signatures of Cancer Cells[{..}] Detection and Diagnosis; Funding; Gene Expression; Gene Proteins; Genes; Genome Scan; Genomics; Global Change; Goals; Grafting, Liver; HBV; HCC; HCV; HCV Chronic Infection; HCV Incidence; Health system; Hematologic Tests; Hematological Tests; Hematology Testing; Hepatic; Hepatic Disorder; Hepatitis B Virus; Hepatitis C Incidence; Hepatitis C virus; Hepatitis C, Chronic; Hepatitis Virus, Homologous Serum; Hepatitus C; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Human; Human, General; Immune response; Individual; Investigators; Lead; Lesion; Liver; Liver Transplant; Liver diseases; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Markers, Serum; Mass Spectrum; Mass Spectrum Analysis; Membrane; Michigan; Molecular Classification of Tumors; Molecular Fingerprinting; Molecular Fingerprinting Initiative; Molecular Profiling; Molecular Profiling Initiative; Neoplastic liver; Patients; Pattern; Pb element; Photometry/Spectrum Analysis, Mass; Polyacrylamide Gel Electrophoresis, 2-D; Polyacrylamide Gel Electrophoresis, 2D; Polyacrylamide Gel Electrophoresis, Two-Dimensional; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary carcinoma of the liver cells; Programs (PT); Programs [Publication Type]; Protein Biochips; Protein Chips; Protein Gene Products; Protein Microarray; Protein Microchips; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteomics; Research Personnel; Researchers; Screening for cancer; Sensitivity and Specificity; Serum; Serum Markers; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Surface; Survival Rate; Technology; Testing; Tissues; Transplantation of liver; Transplantation, Hepatic; Tumor Antigens; Tumor-Associated Antigen; Two-Dimensional Polyacrylamide Gel Electrophoresis; United States; Universities; Validation; Western Blotting; Western Blottings; Western Immunoblotting; autoimmune antibody; base; biomarker; body system, hepatic; cancer microarray; clinical data repository; clinical data warehouse; cohort; data repository; disease causation; disease etiology; disease/disorder etiology; disorder etiology; early cancer detection; early detection; epithelial carcinoma; gene product; heavy metal Pb; heavy metal lead; hepatopathy; high risk; host response; immunogen; immunoresponse; innovate; innovation; innovative; insight; interest; liver disorder; liver transplantation; malignancy; membrane structure; molecuar profile; molecular signature; neoplasm/cancer; neoplastic; novel marker; organ system, hepatic; programs; protein blotting; protein expression; relational database; response; self reactive antibody; transcriptomics; tumor; tumor-specific antigen",Novel markers for HCV-related HCC,,66840,ZRG1,Special Emphasis Panel,S2,5,100000,
8003251,R01,DK,3,Y,01/19/2010,04/30/2010,PA-08-014,3R01DK067561-03A1S1,,NIDDK:11262;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,,08,623216371,US,NY,10019,ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS,"LAFERRERE, BLANDINE B;",7043252;,3R01DK067561,01/19/2010,04/30/2010,"Affect; Antidiabetic Hormone; Blood Glucose; Blood Sugar; Body Weight decreased; Breath Tests; Caloric Restriction; Cell Function; Cell Process; Cell physiology; Cell secretion; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Secretion; Cephulac; Chemotherapy-Hormones/Steroids; Chronulac; D-Fructose, 4-O-beta-D-galactopyranosyl-; D-Glucose; Data; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease remission; Distal; Endocrine Gland Secretion; Exclusion; Foregut; GCG; GIP; GLP-1; GNAI2; GNAI2 gene; GNAI2B; Glucagon; Glucagon (1-29); Glucose; Glukagon; HG-Factor; Hindgut; Hormones; Human; Human, General; Humulin R; Hyperglycemic-Glycogenolytic Factor; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Lactulose; Lipids; Longitudinal Studies; MODY; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Metabolic; Modeling; Morbid Obesity; Morbidity; Morbidity - disease rate; NIDDM; Nature; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutrient; OGTT; Obesity; Obesity, Morbid; Operation; Operative Procedures; Operative Surgical Procedures; Oral; Oral Glucose Tolerance; Oral Glucose Tolerance Test; Patients; Peptides; Play; Prevalence; Primitive foregut structure; Procedures; RMSN; Randomized; Remission; Resolution; Role; Severe obesity; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; T2D; T2DM; Testing; Therapeutic Hormone; Time; Toxic effect; Toxicities; Type 2 diabetes; Type II diabetes; Weight; Weight Loss; Weight Reduction; adiposity; adult onset diabetes; alternative treatment; bariatric surgery; blood glucose regulation; body weight loss; breath analysis; calorie restriction; corpulence; corpulency; corpulentia; diabetes; diabetes control; fasting glucose; gastric banding; gastric bypass surgery; glucagon-like peptide 1; glucose RA; glucose control; glucose homeostasis; glucose production; glucose rate of appearance; glucose regulation; glucose tolerance; glycemic control; ileum; implantable gastric stimulation banding; improved; indexing; insulin secretion; insulin sensitivity; ketosis resistant diabetes; long-term study; maturity onset diabetes; obese; obese people; obese person; obese population; obesity surgery; obesity, extreme; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; public health relevance; randomisation; randomization; randomly assigned; response; social role; stability testing; stomach stapling; surgery; weight loss surgery; wt-loss",Mechanisms of Diabetes Control After Weight Loss Surgery," 7- Project Narrative The increased prevalence of obesity and type 2 diabetes has resulted in a surge in the number of patients seeking surgical weight loss. Gastric bypass surgery (GBP) results in 50-70% excess body weight loss with resolution of type 2 diabetes (T2DM) in 84% of cases. The mechanisms by which diabetes improves after GBP are unclear. Glycemic control occurs long before significant weight loss, suggesting that the nature of the procedure, rather than the weight loss, is responsible for the T2DM improvement. Recent data have singled out the role of the gut hormones known as incretins in diabetes improvement after GBP, but not after another type of surgery, gastric banding (GB). We propose to study, in patients with morbid obesity and T2DM, randomized to GBP or GB, the effect of the surgery in the short and the long term on incretins levels and effect, insulin secretion in response to IV glucose and diabetes control. We wish to apply our findings to possible medical alternatives for the treatment of obesity and T2DM.",67561,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,A1S1,3,11262,
7998757,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK067989-06S1,,NIDDK:7690;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"LIRA, SERGIO A;",7353844;,3R01DK067989,01/15/2010,03/31/2010,"Autoimmune; Autoimmune Process; Blood Vessels; CCL21; CCL21 gene; CKb9; Cells; Cytokines, Chemotactic; Data; Dendritic Cells; Development; Head and Neck, Thyroid; High Endothelial Venule; Homologous Chemotactic Cytokines; Human; Human, General; Immune; Immune system; Intercrines; Link; Lymphatic; Lymphocyte; Lymphocytic; Lymphoid Follicle; MGC34555; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Murine; Mus; Pathogenesis; Receptor Protein; Reporting; Role; SCYA21; SIS cytokines; SLC; Solid; Structure; TCA4; Thyroid; Thyroid Diseases; Thyroid Gland; Thyroid Gland Disease; Thyroid Gland Disorder; Thyroiditis; Transgenic Model; Veiled Cells; Work; autoimmune thyroid disease; autoimmune thyroid disorder; body system, allergic/immunologic; chemoattractant cytokine; chemokine; lymph cell; organ system, allergic/immunologic; receptor; social role; thyroid disorder; vascular",The role of chemokines in experimental thyroiditis,,67989,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S1,6,7690,
8012048,R01,DK,3,Y,01/25/2010,01/24/2011,,3R01DK068361-04S1,,NIDDK:88000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"ANTHONY, DONALD D;",7023699;,3R01DK068361,01/25/2010,01/24/2011,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Affect; Allogenic; Antigen Presentation Pathway; Antigen Processing; Antigen Processing and Presentation; Antigen Processings; Antigens; Antigens, Viral; Assay; Bioassay; Biologic Assays; Biological Assay; Biology; Cell Communication; Cell Function; Cell Interaction; Cell Maturation; Cell Process; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chronic Hepatitis C; Chronic type C viral hepatitis; Chronic viral hepatitis; Chronic viral hepatitis C; Cytofluorometry, Flow; Data; Defect; Dendritic Cells; Disease; Disorder; Dysfunction; Edodekin Alfa; Exposure to; Favorable Clinical Outcome; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Foundations; Functional disorder; Genotype; Goals; HCV; HCV Chronic Infection; HCV infection; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis C, Chronic; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Host Defense; Host Defense Mechanism; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IL-12; IL12; Immune; Immunity; Individual; Infection; Infection Control; Interleukin-12; LAV-HTLV-III; Ligands; Lymphadenopathy-Associated Virus; Measures; Mediating; Memory; Microfluorometry, Flow; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myelogenous; Myeloid; NANBH; NKSF; Natural Killer Cell Stimulatory Factor; Organ; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Patients; Phenotype; Physiopathology; Process; Recombinants; Role; Shapes; Subcellular Process; T memory cell; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; Testing; Therapeutic; Thymus-Dependent Lymphocytes; United States; Veiled Cells; Viral Antigens; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus-HIV; Viruses, General; antigen processing; core protein, HCV; core protein, hepatitis C virus; cytokine; design; designing; disease/disorder; flow cytophotometry; hepatitis C virus nucleocapsid protein; hepatitis C virus nucleoprotein; hepatitis non A non B; hepatitis nonA nonB; immunogen; improved; inhibitor; inhibitor/antagonist; insight; memory T lymphocyte; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; nucleocapsid protein, hepatitis C virus; pathophysiology; peripheral blood; prevent; preventing; response; social role; thymus derived lymphocyte; virus antigen; virus core; virus protein",Role of immature DC in host defense against HCV,,68361,ZRG1,Special Emphasis Panel,S1,4,88000,
8001278,R01,DK,3,Y,01/01/2010,03/31/2010,,3R01DK068596-05S1,,NIDDK:84152;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"ADER, MARILYN ;",1886381;,3R01DK068596,01/01/2010,03/31/2010,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3 Hydroxybutyrate; Abdominal obesity; Abnormal Assessment of Metabolism; Abnormalities, Drug-Induced; Accounting; Adipose tissue; Affective Psychosis, Bipolar; After Care; After-Treatment; Aftercare; Android fat distribution; Animal Model; Animal Models and Related Studies; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Bipolar Disorder; Blood; Blood Circulation; Blood Plasma; Bloodstream; Body Tissues; Body Weight; Brain; Caloric Intake; Calories; Calorimetry, Indirect; Calorimetry, Respiration; Canine Species; Canis familiaris; Catheters; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Central obesity; Centripetal obesity; Chronic; Circulation; Compensation; Defect; Deposit; Deposition; Development; Diabetes Mellitus; Diabetic Acidosis; Diabetic Ketoacidosis; Diet; Disease; Disorder; Dogs; Dose; Drug Prescribing; Drug Prescriptions; Drug effect disorder; Drug-Induced Abnormalities; Drugs; Dysfunction; Dyslipidemias; Eating; Encephalon; Encephalons; Energy Expenditure; Energy Intake; Energy Metabolism; Face; Fasting; Fat body with thin limbs; Fats; Fatty Tissue; Fatty acid glycerol esters; Financial compensation; Food Intake; Functional disorder; Gastrointestinal Tract, Pancreas; Gene Expression; Gluconeogenesis; Hepatic; Hexadecanoates; Human; Human, General; Humulin R; Hydrogen Oxide; Hyperglycemia; Hyperinsulinemia; Hyperinsulinism; Impairment; Implant; In Vitro; Indirect Calorimetry; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Ketones; Ketosis, Diabetic; Label; Levarterenol; Levonorepinephrine; Life; Lipolysis; METBL; Major Tranquilizers; Mammals, Dogs; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Metabolic; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Modeling; Monitor; Nervous System, Brain; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Noradrenaline; Norepinephrine; Novolin R; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Output; Palmitates; Pancreas; Pancreatic; Patients; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical activity; Physiopathology; Pilot Projects; Plasma; Prescriptions, Drug; Proteins; Psychosis, Manic-Depressive; Resistance; Rest; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; Role; Schizophrenia; Schizophrenic Disorders; Series; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Subcellular Process; Telemetries; Telemetry; Testing; Therapeutic; Time; Tissues; Tranquilizing Agents, Major; Truncal obesity; United States; Visceral; Water; Weight Gain; Weight Increase; adipose; adiposity; atypical antipsychotic; base; beta-Hydroxybutyrate; biological signal transduction; bipolar affective disorder; body weight gain; body weight increase; caloric dietary content; calorie (nutrition); canine; cell damage; cell injury; corpulence; corpulency; corpulentia; dementia praecox; diabetes; diabetes risk; diabetic; diabetic ketoacidotic; disease risk; disease/disorder; disorder risk; domestic dog; drug action; drug detection; drug testing; drug/agent; excess adiposity in midsection; experiment; experimental research; experimental study; facial; fasted; fasting glucose; fasts; gene product; ghrelin; glucose biosynthesis; glycogenolysis; hyperglycemic; in vivo; insulin resistant; insulin sensitivity; interventional strategy; male-type obesity; manic depressive disorder; manic depressive illness; metabolic abnormality assessment; model organism; neural control; neural regulation; neuroregulation; obese; obese people; obese person; obese population; pathophysiology; pilot study; research study; resistant; response; schizophrenic; social role; subcutaneous; trunk obesity; urinary; visceral obesity; waist-predominant obesity; white adipose tissue; wt gain; yellow adipose tissue",METABOLIC EFFECTS OF ATYPICAL ANTIPSYCHOTICS,,68596,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,5,84152,
8012480,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK069557-04S1,,NIDDK:99999;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STORRS-MANSFIELD,UNITED STATES,PHARMACOLOGY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"MANAUTOU, JOSE E;",1957091;,3R01DK069557,02/01/2010,01/31/2011,"APAP; ATP-Binding Cassette, Sub-Family B Proteins; Acetamide, N-(4-hydroxyphenyl)-; Acetamidophenol; Acetaminophen; Acetominophen; Active Oxygen; Acute; Acute Liver Failure; Address; Antioxidants; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biliary; Carbon Tetrachloride; Carrier Proteins; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Chemical Injury; Chemicals; Clinical; Clinical Management; Data; Development; Differentiation Factor, B-Cell; Disease; Disorder; Dose; Drug Metabolic Detoxication; Drug toxicity; Drugs; Dysfunction; Enzymes; Event; Excretory function; Exposure to; Fulminating Hepatic Failure; Fulminating Liver Failure; Functional disorder; Gene Expression; Gene Proteins; Genes; HPGF; Health; Hepatic; Hepatic Cells; Hepatic Failure, Acute; Hepatic Failure, Fulminant; Hepatic Parenchymal Cell; Hepatocyte; Hepatocyte-Stimulating Factor; Hepatotoxic effect; Hepatotoxicity; Human; Human, General; Hybridoma Growth Factor; Hydroxyacetanilide; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Individual; Inflammation Mediators; Inflammatory; Injury; Injury to Liver; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Knowledge; Kupffer Cells; Laboratories; Lead; Liver; Liver Cells; Liver Failure, Acute; Liver Failure, Fulminant; Liver Toxicity; MGI-2; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marketing; Mediating; Medication; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Methane, tetrachloro-; Mice; Mice, Knock-out; Mice, Knockout; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Murine; Mus; Myeloid Differentiation-Inducing Protein; N-(4-Hydroxyphenyl)acetanilide; N-Acetyl-p-aminophenol; Natural regeneration; Nuclear; Null Mouse; Oxidative Stress; Oxidative Stress Induced Gene Expression Via Nrf2; Oxidative Stress Pathway; Oxygen Radicals; P-Glycoproteins; Paracetamol; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiopathology; Plasmacytoma Growth Factor; Poisons; Predisposition; Pro-Oxidants; Process; Programs (PT); Programs [Publication Type]; Protein Gene Products; Proteins; Reactive Oxygen Species; Recovery; Regeneration; Regimen; Regulation; Research Personnel; Researchers; Resistance; Rodent; Rodentia; Rodentias; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stellate Sinusoidal Macrophage; Subcellular Process; Susceptibility; Testing; Tetrachloromethane; Toxic Chemical; Toxic Substance; Toxic effect; Toxic effect on liver cells; Toxicities; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transport Proteins; Transporter Protein; Xenobiotics; anti-oxidant; base; biological signal transduction; body system, hepatic; clinical relevance; clinically relevant; cytokine; detoxification; disease/disorder; drug/agent; excretion; experiment; experimental research; experimental study; fulminant hepatic failure; gene product; heavy metal Pb; heavy metal lead; hepatic cell proliferation; hepatic cellular proliferation; hepatocyte cell proliferation; hepatocyte cellular proliferation; hepatocyte proliferation; hepatotoxicant; hepatotoxin; hepatoxicity; inhibitor; inhibitor/antagonist; interferon beta 2; liver cell proliferation; liver cellular proliferation; liver macrophage; organ system, hepatic; p-Acetamidophenol; p-Hydroxyacetanilide; pathophysiology; poison; prevent; preventing; programs; protein expression; regenerate; research study; resistant; response; social role; toxic compound; toxicant; transcription factor",Transporter Expression in Response to Hepatotoxicants,,69557,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,S1,4,99999,
8010999,R01,DK,3,Y,02/01/2010,04/30/2010,PA-02-161,3R01DK069603-04S2,,NIDDK:78876;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"POWERS, ALVIN CARTER;",1882614;,3R01DK069603,02/01/2010,04/30/2010,"Affect; Angiogenic Factor; Architecture; B9 endocrine pancreas; Blood Glucose; Blood Sugar; Blood Vessels; Blood flow; Body Tissues; Cells; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Endocrine; Endothelial Cells; Engineering / Architecture; Eph Receptor Ligands; Ephrins; Event; Factor, Angiogenesis; Gastrointestinal Tract, Pancreas; Gene Deletion; Gene Expression; Genes; Grafting, Islets of Langerhans; HBGF; Human; Human, General; Humulin R; IDD; IDDM; In Vitro; Inferior; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intervention; Intervention Strategies; Ischemia; Islands of Langerhans; Islet Cell; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Knowledge; Lead; Man (Taxonomy); Man, Modern; Molecular; Nesidioblasts; Novolin R; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pb element; Physiology; Play; Production; Role; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Time; Tissues; Transplantation; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 1 diabetes; VEGFs; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vascular blood supply; Vascularization; Vasculotropin; Vegf; angiogenesis; beta cell development; blood supply; density; endocrine pancreas; endocrine pancreas development; gene deletion mutation; heavy metal Pb; heavy metal lead; improved; in vivo; inhibitor; inhibitor/antagonist; insight; insulin dependent diabetes; insulin secretion; interventional strategy; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; new therapeutics; next generation therapeutics; novel therapeutics; response; social role; transplant; tumor; type I diabetes; vascular; vascular supply; vasculogenesis",VEGF and Islet Vascularization,,69603,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S2,4,78876,
7998502,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK069713-04S1,,NIDDK:45000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"DAVIES, TERRY FRANCIS;",1867741;,3R01DK069713,02/01/2010,04/30/2010,"3'5'-cyclic ester of AMP; ATGN; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affinity; Agonist; Animal Model; Animal Models and Related Studies; Antibodies; Antibody Repertoire; Antigenic Determinants; Antigens; Assay; Autoantibodies; Autoimmune Status; Autoimmunity; Basedow's Disease; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Blood Serum; CHO Cells; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chinese Hamster Ovary Cell; Cloning; Combining Site; Complex; Cricetinae; Cyclic AMP; Data; Derivation; Derivation procedure; Development; Digestion; Dysfunction; Energy Transfer; Epitopes; Functional disorder; Gamma Globulin, 7S; Generalized Growth; Generations; Goiter, Exophthalmic; Graves' Disease; Growth; Hamsters; Head and Neck, Thyroid; IgG; Immunoglobulin G; Intracellular Communication and Signaling; Investigators; Jobs; LRR; Laboratories; Lateral; Leucine-Rich Repeat; Ligands; Long-Acting Thyroid Stimulator; Mammals, Hamsters; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediating; Moab, Clinical Treatment; Modeling; Molecular; Molecular Interaction; Monoclonal Antibodies; Movement; Mutate; Occupations; Patients; Photobleaching; Photometry/Spectrum Analysis, Mass; Physiopathology; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Professional Postions; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Publishing; Reactive Site; Receptor Protein; Receptors, Thyroid Stimulating Hormone; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Recovery; Regulation; Reporting; Research Personnel; Researchers; Right-Handed Beta-Alpha Superhelix; Role; Serum; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; TSH Receptors; TSH receptor antibody; Testing; Thyreotropin; Thyroid; Thyroid Gland; Thyroid Stimulating Hormone; Thyroid stimulating immunoglobulins; Thyroid-Stimulating Antibodies; Thyroid-Stimulating Hormone; Thyrotropin; Thyrotropin Receptor; Tissue Growth; adenosine 3'5' monophosphate; autoimmune antibody; base; biological signal transduction; body movement; cAMP; computerized data processing; data processing; human disease; immunogen; immunogenic; improved; indexing; insight; model organism; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; pathophysiology; receptor; response; self reactive antibody; self recognition (immune); signal processing; social role; success",Monoclonal Thyroid Stimulating Antibodies,,69713,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S1,4,45000,
8003242,R01,DK,3,Y,01/11/2010,09/30/2010,,3R01DK069766-05S1,,NIDDK:89550;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOUISVILLE,UNITED STATES,SURGERY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"ILDSTAD, SUZANNE T;",1882948;,3R01DK069766,01/11/2010,09/30/2010,"ATGN; Acute; Address; Adverse effects; Allogenic; Allografting; Antigens; Apoptosis; Apoptosis Pathway; Apoptotic; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Blood Precursor Cell; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Cell Death, Programmed; Cell Therapy; Cells; Cessation of life; Chimerism; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Data; Death; Dendritic Cells; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Doctor of Medicine; Engraftment; GVHD; Generations; Goals; Graft-Versus-Host Disease; Graft-vs-Host Disease; Grafting, Bone Marrow; Grafting, Islets of Langerhans; HSC transplantation; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hematopoietic-CGF; Hematopoietins; Homologous Wasting Disease; Humulin R; IDD; IDDM; Immune; Immune response; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunomodulation; Immunostimulation; In Vitro; Inbred NOD Mice; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Islets of Langerhans Transplantation; Journals; M.D.; Magazine; Maintenance; Maintenances; Marrow; Marrow Transplantation; Medicine; Methods; Mice, Inbred NOD; Morbidity; Morbidity - disease rate; Mouse, NOD; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; Phenotype; Population; Principal Investigator; Production; Productivity; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Regimen; Regulatory T-Lymphocyte; Reticuloendothelial System, Bone Marrow; Role; Runt Disease; Science of Medicine; Sensitization, Immunologic; Sensitization, Immunological; Staging; T-Cell Activation; T-Lymphocyte, Regulatory; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Therapy, Cell; Time; Transplantation; Transplantation Immunology; Transplantation Tolerance; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Treatment Side Effects; Type 1 diabetes; Veiled Cells; anergy; autoimmune disorder; blood glucose regulation; cell type; cell-based therapy; clinical applicability; clinical application; clinical investigation; conditioning; diabetes; disease prevention; disorder prevention; experiment; experimental research; experimental study; glucose control; glucose homeostasis; glucose regulation; hematopoietic growth factor; host response; immune modulation; immunogen; immunologic reactivity control; immunoregulation; immunoresponse; in vivo; insulin dependent diabetes; interest; islet; islet allograft; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; mouse model; novel; prevent; preventing; programs; research study; reverse tolerance; self recognition (immune); side effect; social role; systemic autoimmune disease; therapy adverse effect; transplant; treatment adverse effect; trial regimen; trial treatment; type I diabetes",Tolerance Induction to Islet Transplants,,69766,TTT,"Transplantation, Tolerance, and Tumor Immunology",S1,5,89550,
8010062,R01,DK,3,Y,01/15/2010,03/31/2011,,3R01DK069950-05S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AUGUSTA,UNITED STATES,PHYSIOLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"RAINEY, WILLIAM E;",1887609;,3R01DK069950,01/15/2010,03/31/2011,"3beta-Hydroxyandrost-5-en-17-one; 5-Androsten-3-beta-hydroxy-17-one; 6 year old; 8 year old; ADRGND; Address; Adrenal Cortex; Adrenal Fasciculata; Adrenal Glands; Adrenal Glomerulosa; Adrenal Reticularis; Adrenals; Aeroseb-HC; Age; Aldosterone; Anabolism; Androgenic Agents; Androgenic Compounds; Androgens; Androst-5-en-17-one, 3-hydroxy-, (3beta)-; Androstenolone; Armpit; Axilla; Axillary; Biochemical; Biological Models; CPT7; CYP17; CYP17A1; CYP17A1 gene; Cell Culture Techniques; Cell/Tissue, Immunohistochemistry; Cells; Cetacort; Coenzymes; Cofactors, Enzyme; Cort-Dome; Cortef; Cortenema; Cortex of adrenal gland; Cortisol; Cortispray; Cortril; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytochrome b-5; Cytochromes b5; DHA Sulfate; DHEA; DHEA Sulfate; DHEA sulfotransferase; DHEA sulphotransferase; DNA Methylation; Data; Dehydroepiandrosterone Sulfate; Dehydroisoandrosterone; Dehydroisoandrosterone Sulfate; Dermacort; Development; Disease; Disorder; Eldecort; Endocrine Physiology; Enhancer Elements; Enhancer Elements (Genetics); Entire hair of pubis; Enzymes; Expression Profiling; Expression Signature; Family; Family member; Ferricytochrome b5; GATA-6 protein; GATA6 protein; GATA6 transcription factor; GFRP1; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Goals; HMR; Human; Human, General; Hydrocortisone; Hydrocortone; Hydroxylases; Hydroxysteroid Dehydrogenases; Hytone; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Inorganic Sulfates; Link; Lyase; MGC9485; Man (Taxonomy); Man, Modern; Microarray Analysis; Microarray-Based Analysis; Mixed Function Oxidases; Mixed Function Oxygenases; Model System; Modeling; Models, Biologic; Molecular; Molecular Fingerprinting; Molecular Profiling; Monooxygenases; N10; NAK-1; NAK1; NGFIB; NP10; NR4A1; NR4A1 gene; NUR77; Nutracort; P450; P450C17; Pathway interactions; Pattern; Prasterone; Prasterone Sulfate; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Process; Proctocort; Production; Protein-Tyrosine Kinases, src; Pubic Hair; RNA Expression; Regulation; Role; S17AH; Secondary to; Signal Pathway; Site; Steroid Compound; Steroids; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; TR3; Therapeutic Androgen; Therapeutic Dehydroepiandrosterone; Therapeutic Hydrocortisone; Time; Trans-Acting Factors; Trans-Activators; Transactivators; Transcription; Transcription, Genetic; Underarm; Unspecified or Sulfate Ion Sulfates; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; Zona Fasciculata; Zona Glomerulosa; Zona Reticularis; base; biosynthesis; boys; clinical relevance; clinically relevant; coenzyme analog; dehydroepiandrosterone; dehydroepiandrosterone sulfotransferase; disease/disorder; eight year old; electron donor; genetic enhancer element; girls; insight; microarray technology; molecuar profile; molecular signature; pathway; premature; protein expression; six year old; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; sulfate; suprarenal gland; trans acting factor (genetic); transcription factor; transcription factor GATA-6",Molecular Mechanisms of Adrenarche,,69950,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S1,5,100000,
8011268,R01,DK,3,Y,01/20/2010,12/31/2010,PA-05-049,3R01DK069984-04S2,,NIDDK:64027;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KATZ, JONATHAN P;",2131289;,3R01DK069984,01/20/2010,12/31/2010,"21+ years old; Ablation; Abscission; Acids; Adult; Alimentary Canal; Antiheparin Factor; Autoregulation; Biochemical; Blood Platelet Factor IV; Blood platelet factor 4; Body Tissues; CK-19; CK19; Cancers; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Chemokine (C-X-C motif) Ligand 4; Colon; Cytokeratin 19; Development; Digestive Tract; EZF protein; Ectopic Expression; Embryo; Embryonic; Epithelial; Epithelial Cells; Epithelial Dysplasia; Epithelium; Equilibrium; Esophageal; Esophageal mucous membrane; Esophagus; Excision; Extirpation; Factor 4; GI Tract; GKLF protein; Gastroenterology; Gastrointestinal Tract; Gastrointestinal Tract, Esophagus; Gastrointestinal Tract, Pancreas; Gastrointestinal tract structure; Generalized Growth; Genes; Genes, Viral; Genetic; Growth; Heparin Neutralizing Protein; Histology; Homeostasis; Human; Human, Adult; Human, General; Infection; Injury; Intraepithelial Neoplasia; Intraepithelial Neoplasms; Investigators; Keratin; Keratin-19; Klf4 protein; Kruppel-like factor 4; Link; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Molecular; Murine; Mus; Nature; Pancreas; Pancreatic; Physiological Homeostasis; Platelet Factor 4; Play; Polyps; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA, Messenger; RNA, Small Interfering; Recombinant Platelet Factor 4; Reflux; Regulation; Removal; Research Personnel; Researchers; Retroviridae; Retroviruses; Role; Skin; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Small Interfering RNA; Stomach; Subcellular Process; Surgical Removal; Testing; Tissue Growth; Tissues; Viral Genes; Virus-Retrovirus; adult human (21+); alimentary tract; balance; balance function; cell transduction; cellular transduction; design; designing; digestive canal; epithelial zinc finger protein; esophageal mucosa; gamma-Thromboglobulin; gastric; gut-enriched Kruppel-like factor; in vivo; insight; mRNA; malignancy; neoplasm/cancer; null mutation; ontogeny; overexpression; platelet factor IV; postnatal; programs; resection; siRNA; social role; transcription factor; transduced cells",Regulation of differentiation in esophageal epithelia,,69984,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,S2,4,64027,
8009205,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-070,3R01DK070024-05S1,,NIDDK:40104;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"INGRAHAM, HOLLY A.;",1872897;,3R01DK070024,02/01/2010,04/30/2010,"AD4BP protein; ADRGND; Ad4-binding protein; Address; Adrenal Gland Insufficiency; Adrenal Glands; Adrenal Insufficiency; Adrenal gland hypofunction; Adrenals; Affect; Alleles; Allelomorphs; Animals; Biochemical; Biochemistry; Birth; Body Tissues; CHIP assay; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cells; ChIP (chromatin immunoprecipitation); Chemistry, Biological; Chemotherapy-Hormones/Steroids; Corpus Luteum Hormone; Crystallographies; Crystallography; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; Data; Defect; Delta4-pregnene-3,20-dione; Deoxyribonucleic Acid; Development; Developmental Process; Dysfunction; Elements; Embryo; Embryonic; Embryonic Tissue, Placenta; Endocrine; Endocrine Gland Secretion; Endocrine system; Endocrine system (all sites); Endocrine/Metabolic Organ System; Enzymes; Exhibits; Expression Profiling; Expression Signature; FTZF1 protein; Functional disorder; Fushi tarazu factor homolog 1; Gene Expression; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic defect; Gestation; Grant; Hormonal; Hormonal System; Hormones; Hypoadrenalism; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; Knockout Mice; L-Lysine; Lead; Life; Lysine; Mammals, Mice; Metabolic/Endocrine Body System; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Fingerprinting; Molecular Profiling; Molecular Stereochemistry; Murine; Mus; Mutant Strains Mice; Mutation; NR5A1 protein; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nuclear Receptors; Null Mouse; Output; Parturition; Pathway interactions; Pb element; Phosphorylation; Physiologic; Physiological; Physiology; Physiopathology; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Pregn-4-ene-3,20-dione; Pregnancy; Pregnenedione; Progesterone; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Modification; Protein Modification, Post-Translational; Protein Motifs, DNA-Binding; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Public Health; Receptor Protein; Relative; Relative (related person); Response Elements; Role; SF 1; SF-1 transcription factor; SF1; Signal Transduction; Signal Transduction Systems; Signaling; Site; Targetings, Gene; Testing; Therapeutic Hormone; Therapeutic Progesterone; Time; Tissues; Work; adrenal 4 binding protein; biological signal transduction; chromatin immunoprecipitation; comparative; conformation; conformational state; endocrine gland/system; gene product; genome mutation; heavy metal Pb; heavy metal lead; high risk; hypothalamic pituitary gonadal axis; in vivo; insight; loss of function; molecuar profile; molecular signature; mouse mutant; mutant; nuclear receptor 5A1 protein; pathophysiology; pathway; prevent; preventing; programs; public health medicine (field); public health relevance; receptor; social role; steroid hormone receptor Ad4BP; steroidogenic factor 1; structural biology; structural genomics; suprarenal gland; transcription factor; transcription factor sf1",Modulating Nuclear Receptor Activity via Sumoylation," Project Narrative/Relevance to Public Health Post-translational modifications regulate the activity of many types of cellular proteins. Sumoylation of proteins involves protein conjugation and in general dampens the activity of many transcriptional regulators. In this study we will assess for the first time, how a sumo-deficient mutation of the nuclear receptor affects endocrine tissue development and function. Results from this work will potentially identify important new gene targets that are especially sensitive to the relative pools of sumoylated protein. They will also provide mechanistic insight into how sumoylation restrains and ""fine tunes"" transcriptional programs of the endocrine system.",70024,MCE,Molecular and Cellular Endocrinology Study Section,S1,5,40104,
8012062,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK070195-05S1,,NIDDK:99930;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,KANSAS CITY,UNITED STATES,PHARMACOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"JAESCHKE, HARTMUT W;",1987845;,3R01DK070195,02/01/2010,01/31/2011,"ADP-Ribosyltransferase (Polymerizing); APAP; Acetamide, N-(4-hydroxyphenyl)-; Acetamidophenol; Acetaminophen; Acetominophen; Active Oxygen; Acute; Acute Liver Failure; Animals; Attenuated; Bioenergetic; Bioenergetics; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cell Communication and Signaling; Cell Death; Cell Death Signaling; Cell Death Signaling Process; Cell Function; Cell Membrane Permeability; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Data; Desminase; Drug toxicity; Drugs; Dysfunction; Event; Family member; Fulminating Hepatic Failure; Fulminating Liver Failure; Functional disorder; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Hepatic Cells; Hepatic Failure; Hepatic Failure, Acute; Hepatic Failure, Fulminant; Hepatic Parenchymal Cell; Hepatocyte; Hepatotoxic effect; Hepatotoxicity; Human; Human, General; Hydroxyacetanilide; Ingestion; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Liver Cells; Liver Failure; Liver Failure, Acute; Liver Failure, Fulminant; Liver Toxicity; Man (Taxonomy); Man, Modern; Medication; Mitochondria; N element; N-(4-Hydroxyphenyl)acetanilide; N-Acetyl-p-aminophenol; N2 element; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; Natural regeneration; Necrosis; Necrotic; Nitrogen; Nuclear; Nucleus; O element; O2 element; Overdose; Oxygen; Oxygen Radicals; PARP Polymerase; PARS; Papain-Like Cysteine Protease; Paracetamol; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiopathology; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Pro-Oxidants; Process; Proteins; Publishing; Reactive Oxygen Species; Recovery; Regeneration; Role; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Staging; Subcellular Process; Testing; Therapeutic Intervention; Toxic effect on liver cells; acetaminophen overdose; base; biological signal transduction; cell damage; cell injury; drug/agent; endonuclease G; fulminant hepatic failure; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; hepatoxicity; in vivo; injured; innovate; innovation; innovative; insight; intervention therapy; interventional strategy; macromolecule; membrane permeability; mitochondrial; mitochondrial dysfunction; mitochondrial membrane; necrocytosis; novel; novel therapeutic intervention; p-Acetamidophenol; p-Hydroxyacetanilide; pathophysiology; poly ADP polymerase; poly ADP ribose synthetase; prevent; preventing; regenerate; social role",Mitochondrial Dysfunction and Drug Hepatotoxicity,,70195,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,S1,5,99930,
8006977,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK070650-05S1,,NIDDK:99801;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"SOPRANO, DIANNE R;",1881258;,3R01DK070650,01/15/2010,12/31/2010,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 9-cis-Retinoic Acid Receptor; ATRA; Abbreviations; All-trans retinoic acid; Amino Acids; BMP-4; Biological Models; Bone Morphogenetic Proteins; Cardiac; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Development; Differentiation and Growth; Embryo Development; Embryogenesis; Embryonal Carcinoma Cell; Embryonic Development; Endoderm Cell; Endodermal Cell; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Goals; HOX protein; Homeo Domain Proteins; Homeobox Family Protein; Homeobox Proteins; Homeodomain Family Protein; Homeodomain Proteins; Homeoproteins; Homeotic Proteins; Immune response; Intracellular Communication and Signaling; Leukemia, Pre-B-Cell; Mediating; Messenger RNA; Model System; Models, Biologic; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; PBX3; PBX3 gene; Pathway interactions; Phenotype; Play; Pre-B-Cell Leukemia; Proteins; RNA Expression; RNA, Messenger; RXR; RXR Protein; Receptor Activation; Reproduction; Retinoic Acid; Retinoic Acid Receptor; Retinoic Acid Receptor RXR; Retinoid Receptor; Retinoid X Receptors; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Trans Vitamin A Acid; Transcription; Transcription, Genetic; Tretinoin; Tretinoinum; Vitamin A; Vitamin A Acid; all-trans-Retinoic Acid; all-trans-Vitamin A acid; aminoacid; biological signal transduction; bone morphogenetic gene product-4; bone morphogenetic protein 4; decorin; gene product; host response; immunoresponse; mRNA; neuronal; pathway; protein function; retinol; social role; trans-Retinoic Acid; transcription factor",PBX AND Retinoic Acid-dependent Differentiation,,70650,INMP,Integrative Nutrition and Metabolic Processes Study Section,S1,5,99801,
8009168,R01,DK,3,Y,01/08/2010,03/31/2010,PA-03-145,3R01DK070787-05S1,,NIDDK:45728;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"WADZINSKI, BRIAN E;",1863113;,3R01DK070787,01/08/2010,03/31/2010,"70-kDa Ribosomal Protein S6 Kinases; APF-1; ATP-Dependent Proteolysis Factor 1; Address; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antigenic Determinants; Apoptosis; Apoptosis Pathway; Assay; Autoregulation; BBB syndrome; BBBG syndrome; BBG syndrome; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Cycle Progression; Cell Death, Programmed; Cell Fractionation; Cell Function; Cell Growth and Maintenance; Cell Maintenance; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Complex; Coupled; Data; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diabetes Mellitus; Disease; Disorder; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7.2-; Enzymes; Epitopes; Extracellular Signal-Regulated Kinases; FG Syndrome; Family; G syndrome; G/BBB syndrome; GBBB syndrome; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; HMG-20; High Mobility Protein 20; Homeostasis; Impairment; In Vitro; Intracellular Communication and Signaling; Investigation; Investigators; Keller syndrome; Laboratories; Lead; Link; MAP kinase; MAPK; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Mediating; Micro-tubule; Microtubules; Mitogen-Activated Protein Kinases; Modification; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Monitor; Mono-S; MonoS; Monoubiquitination; Morphology; Mutation; Normal Cell; Opitz syndrome; Opitz syndrome (OS); Opitz-Frias syndrome; Opitz-Kaveggia syndrome; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTPA; Pathology; Patients; Pb element; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosyl Phosphatase Activator; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiological Homeostasis; Play; Polyubiquitination; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Protein Modification; Protein Modification, Post-Translational; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Serine/Threonine Phosphatase; Protein Trafficking; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Protocol; Protocols documentation; RBX1 protein, human; RING Box Protein 1; RING Finger Protein; RING Finger Protein 75; Regulation; Regulator of Cullins 1; Research; Research Personnel; Researchers; Ribosomal Protein S6 Kinases, 70-kDa; Roc1 protein, human; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stimulus; Subcellular Process; Testing; Therapeutic; Traffickings, Protein; Transgenic Animals; Ubiquitilation; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Viral Diseases; Virus Diseases; X-linked Opitz syndrome; X-linked Opitz syndrome (XLOS); ZYP Protein; autosomal dominant Opitz syndrome; autosomal dominant Opitz syndrome (ADOS); base; biological signal transduction; cell growth; dementia of the Alzheimer type; diabetes; disease/disorder; dosage; gene product; genome mutation; heavy metal Pb; heavy metal lead; human RBX1 protein; hypertelorism-hypospadias syndrome; hypospadias-dysphagia syndrome; in vivo; insight; malformation; malignancy; mutant; neoplasm/cancer; novel; oculo-genito-laryngeal syndrome; overexpression; p70 S6 Kinase; p70s6k; primary degenerative dementia; programs; protein protein interaction; protein transport; ring-box 1 protein, human; senile dementia of the Alzheimer type; serine-threonine phosphatase; social role; subcellular fractionation; telecanthus-hypospadias syndrome; tissue/cell culture; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase; viral infection; virus infection","Mechanism, regulation and function of PP2A ubiquitination",,70787,CAMP,Cancer Molecular Pathobiology Study Section,S1,5,45728,
8010058,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK071021-05S1,,NIDDK:11000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,IRVINE,UNITED STATES,BIOCHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"OSBORNE, TIMOTHY F;",1922311;,3R01DK071021,01/15/2010,12/31/2010,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; Accounting; Acids, Bile; Affect; Animal Model; Animal Models and Related Studies; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bile Acid Biosynthesis; Bile Acid Biosynthesis Pathway; Bile Acids; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Serum; CHIP assay; CP7A; CYP7; CYP7A1; CYP7A1 gene; Cancers; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell membrane; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Homeostasis; Complications of Diabetes Mellitus; Cytoplasmic Membrane; D-Glucose; DNA; DNA Binding; DNA Binding Interaction; DNA-Binding Proteins; Defect; Deoxyribonucleic Acid; Development; Dextrose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Diabetes-Related Complications; Diabetic Complications; Diabetic mouse; Diathesis; Disease; Disease susceptibility; Disorder; Energy Expenditure; Energy Metabolism; Enzymes; Fasting; Fats; Fatty acid glycerol esters; Feedback; Gallbladder Calculus; Gallbladder Stone; Gallstones; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genetic; Glucose; Hepatic; Human; Human, General; Humulin R; IDD; IDDM; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intermediary Metabolism; Intracellular Communication and Signaling; Link; Liver; METBL; MODY; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Molecular Interaction; Monitor; Murine; Mus; Muscle; Muscle Tissue; NIDDM; NR0B2 protein; Nervous System Physiology; Neurologic function; Neurological function; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutrient; Obesity; Orphan; Pathway interactions; Phenotype; Physiologic; Physiological; Plasma Membrane; Population; Predisposition; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publications; Receptor Protein; Regulation; Research; Role; Route; SHP protein; STZ; Scientific Publication; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Solutions; Staging; Streptozocin; Streptozotocin; Susceptibility; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; T2D; T2DM; Techniques; Testing; Tet; Tetanus Helper Peptide; Tetracycline Antibiotic; Tetracyclines; Transfection; Type 1 diabetes; Type 2 diabetes; Type II diabetes; Work; Zanosar; adiposity; adult onset diabetes; atheromatosis; atherosclerotic vascular disease; base; bile acid anabolism; bile acid biosynthetic process; bile acid formation; bile acid synthesis; biological signal transduction; body system, hepatic; cell growth; cholelith; cholesterol metabolism; chromatin immunoprecipitation; corpulence; corpulency; corpulentia; diabetes; disease/disorder; disease/disorder proneness/risk; fasted; fasts; fat metabolism; gene product; genetic manipulation; glucose RA; glucose metabolism; glucose production; glucose rate of appearance; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; liability to disease; lipid metabolism; malignancy; maturity onset diabetes; model organism; mouse model; mouse model of diabetes; neoplasm/cancer; nervous system function; novel; obese; obese people; obese person; obese population; organ system, hepatic; pathway; plasmalemma; prevent; preventing; programs; protein protein interaction; receptor; response; small heterodimer partner; small heterodimer partner protein; social role; steroid hormone biosynthesis; type I diabetes",Integrated Regulation of Bile Acids and Diabetes,,71021,ZRG1,Special Emphasis Panel,S1,5,11000,
8012059,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK071111-04S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"GUPTA, SANJEEV ;",1863727;,3R01DK071111,02/01/2010,01/31/2011,"A Mouse; Address; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animals; Antihemophilic Factor; Area; Behavior; Biological; Biological Models; Blood Coagulation Factor; Blood Coagulation Factor VIII; Blood-coagulation factor VIII, complex; Cell Communication; Cell Differentiation Induction; Cell Interaction; Cell Survival; Cell Therapy; Cell Transplantation; Cell Transplants; Cell Viability; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-to-Cell Interaction; Cells; Cellular biology; Coagulation Factor VIII; Coagulation Factor VIIIc; Coagulation Factors; Development; Discontinuous Capillary; Disease; Disorder; Endothelial Cells; Engraftment; Factor VIII; Factor VIII Deficiency; Factor VIII F8B; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genes, Reporter; Genetic; Genetic Intervention; Goals; Grafting, Liver; HGF/SF; Hemophilia; Hemophilia A; Hemophilia As; Hepatic; Hepatic Cells; Hepatic Mass; Hepatic Parenchymal Cell; Hepatocyte; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; Human; Human, General; Immune response; Immunodeficient Mouse; Intervention, Genetic; Investigators; Knockout Mice; Lentiviral Vector; Lentivirus Vector; Liver; Liver Cells; Liver Mass; Liver Regeneration; Liver Transplant; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Model System; Modeling; Models, Biologic; Modification; Molecular Biology, Gene Therapy; Mother Cells; Murine; Mus; Natural History; Null Mouse; Paracrine Communication; Paracrine Signaling; Physiologic; Physiological; Population; Process; Procoagulant Component; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Property; Property, LOINC Axis 2; Reporter Genes; Research Personnel; Researchers; Scatter Factor; Science of Anatomy; Sinusoid; Sinusoidal Capillary; Stem cells; Stimulus; System; System, LOINC Axis 4; Testing; Therapeutic; Therapy, Cell; Therapy, DNA; Thromboplastinogen; Transgenes; Transplantation; Transplantation of liver; Transplantation, Hepatic; Transplants, Cell; Treatment Efficacy; VEGFs; Vascular Endothelial Growth Factors; Vegf; Viral Vector; Work; anatomy; antihemophilic factor A; base; body system, hepatic; cell biology; cell type; cell-based therapy; clinical applicability; clinical application; clotting factor; disease/disorder; gene therapy; genetic manipulation; genetic therapy; host response; human disease; human stem cells; immunoresponse; improved; in vivo; insight; intercellular communication; liver transplantation; model organism; mouse model; novel; organ system, hepatic; platelet cofactor I; precursor cell; programs; response; stem; stem cell biology; therapeutic efficacy; therapeutic gene; therapeutically effective; thromboplastinogen A; transplant",Transplantation of Endothelial Cells,,71111,HBPP,Hepatobiliary Pathophysiology Study Section,S1,4,100000,
8004326,R01,DK,3,Y,01/22/2010,12/31/2010,,3R01DK071707-03S1,,NIDDK:48500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,COLLEGE STATION,UNITED STATES,VETERINARY SCIENCES,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"CHAPKIN, ROBERT STEPHEN;",1864268;,3R01DK071707,01/22/2010,12/31/2010,"ATGN; Address; Affect; Allergic; Allergy; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigens; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Attenuated; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Membrane Lipids; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell membrane; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Clinical Research; Clinical Study; Communicable Diseases; Complex; Complexes, Macromolecular; Cytokine Activation; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytoplasmic Membrane; DHA; Data; Development; Disease; Disease Resistance; Disorder; Docosahexaenoic Acids; Docosahexenoic Acids; Effector Cell; Environment; Epidemiology; Equilibrium; Fats; Fatty Acids, Omega-3; Fatty Acids, Polyunsaturated; Fatty acid glycerol esters; Goals; Guidelines; Health; Hypersensitivity; IL-10; IL10; IL10A; INFLM; Immune; Immune response; Immune system; Incidence; Individual; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interleukin 10 Precursor; Interleukin-10; Intracellular Communication and Signaling; Knockout Mice; Lead; Lipid Rafts, Cell Membrane; Lipids; MHC Receptor; Macromolecular Complexes; Maintenance; Maintenances; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Membrane; Membrane Lipids; Membrane Microdomains; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Murine; Mus; Null Mouse; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Outcome; Pathogenesis; Pathologic; Pb element; Phosphatides; Phospholipids; Plasma Membrane; Play; Polyunsaturated Fatty Acids; Production; Property; Property, LOINC Axis 2; Pupa; Receptor Activation; Receptor Signaling; Receptors, Antigen, T-Cell; Resistance; Resistance, Disease; Role; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Subcellular Process; T Cell Receptor Signaling Pathway; T-Cell Activation; T-Cell Proliferation; T-Cell Receptor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; Testing; Th-1 Cell; Th-2 Cell; Th1 Cells; Th2 Cells; Thymus-Dependent Lymphocytes; Transgenic Mice; Type 1 Helper Cell; Type 2 Helper Cell; Vaccination; Work; balance; balance function; bioactive food component; biological signal transduction; body system, allergic/immunologic; design; designing; disease/disorder; experiment; experimental research; experimental study; extracellular; feeding; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunoresponse; in vivo; infectious organism; lipid raft; membrane structure; mouse model; n-3 Fatty Acids; new therapeutics; next generation therapeutics; novel therapeutics; omega-3; organ system, allergic/immunologic; pathogen; plasmalemma; polarized cell; polyunsaturated fatty acid; prevent; preventing; protective effect; protein function; research study; resistance to disease; resistant; resistant disease; resistant to disease; response; self recognition (immune); social role; thymus derived lymphocyte; tool",n-3 Fatty Acids Alter T-cell Activation and Signaling,,71707,INMP,Integrative Nutrition and Metabolic Processes Study Section,S1,3,48500,
8004323,R01,DK,3,Y,01/15/2010,12/31/2010,PA-04-092,3R01DK071817-05S1,,NIDDK:50798;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,MISCELLANEOUS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"BURKE, LORA E;",1910279;,3R01DK071817,01/15/2010,12/31/2010,"Adherence; Adherence (attribute); Behavior; Behavioral; BlackBerry Device; Blueberry Device; Body Weight decreased; C-reactive protein; Chronic; Clinical; Coronary Disease; Coronary heart disease; D-Glucose; Dextrose; Diaries; Diaries (PT); Diaries [Publication Type]; Eating; Electronics; Emergent Technologies; Emerging Technologies; Enrollment; Exercise; Exercise, Physical; Feedback; Food Intake; Glucose; Habits; Health; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intervention; Intervention Strategies; Lipids; Maintenance; Maintenances; Methods; Monitor; Novolin R; Obesity; Outcome; PDA Computer; Palm Pilot; Palm-top; Palm-top computer; Palmtop; Palmtop computer; Paper; Participant; Pattern; Personal Digital Assistant; Personal Digital Assistant Computer; Physical activity; Pocket PCs; Pocket Personal Computer; Prevalence; Proteins, specific or class, C-reactive; Protocols, Treatment; RGM; Randomized; Regimen; Relapse; Research; Risk Factors; Self Management; Supervision; Technology; Testing; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; Writing; adiposity; body weight loss; cardiac disease risk; cardiac disorder risk; coronary disorder; corpulence; corpulency; corpulentia; diaries; enroll; food monitoring; food supply monitoring; food supply surveillance; food surveillance; heart disease risk; heart disorder risk; improved; innovate; innovation; innovative; instrument; interventional strategy; obese; obese people; obese person; obese population; randomisation; randomization; randomly assigned; success; treatment effect; weight control; wt-loss",Improving Self-Monitoring in Weight Loss with Technology,,71817,PRDP,Psychosocial Risk and Disease Prevention Study Section,S1,5,50798,
8012164,R01,DK,3,Y,02/01/2010,01/31/2011,,3R01DK071841-05S1,,NIDDK:99998;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"LOOMES, KATHLEEN MARY;",1861889;,3R01DK071841,02/01/2010,01/31/2011,"Ablation; Alagille Syndrome; Alagille syndrome (AGS); Alagille-Watson Syndrome; Alagille-Watson syndrome (AWS); Assay; Bile Ducts; Bile duct structure; Biliary; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Breeding; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Childhood; Cholestasis with Peripheral Pulmonary Stenosis; Complementary DNA; Cytokeratin; DNA, Complementary; Development; Differential Gene Expression; Disease; Disorder; Ductal; Dysplasia, Arteriohepatic; Embryo; Embryonic; Gene Targeting; Genes; Genetic; Genetic Diseases, Inborn; Genotype; Hepatic Cells; Hepatic Ductular Hypoplasia, Syndromatic; Hepatic Parenchymal Cell; Hepatic ductular hypoplasia; Hepatocyte; Human; Human, General; Inborn Genetic Diseases; Inherited disorder; Intracellular Communication and Signaling; Intrahepatic bile duct; Investigators; Knock-out; Knockout; Knockout Mice; Ligands; Liver; Liver Cells; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mutant Strains Mice; Notch Signaling Pathway; Null Mouse; Organ System; Pathway interactions; Pattern; Phenotype; Population; Programs (PT); Programs [Publication Type]; Proteolysis and Signaling Pathway of Notch; RT-PCR; RTPCR; Regulation; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Staging; Stimulus; System; System, LOINC Axis 4; Targetings, Gene; Time; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Transgenic Organisms; Watson-Miller syndrome; arteriohepatic dysplasia; arteriohepatic dysplasia (AHD); bile duct; bile ductule; biological signal transduction; body system; body system, hepatic; cDNA; cDNA Arrays; cDNA Microarray; cardiovertebral syndrome; cholestasis-peripheral pulmonary stenosis; cultured cell line; disease/disorder; hepatic ductular hypoplasia-multiple malformations syndrome; hepatofacioneurocardiovertebral syndrome; inborn error; jagged-1; jagged1 protein; microarray technology; mouse model; mouse mutant; mutant; notch; notch protein; notch receptors; novel; organ system, hepatic; pathway; paucity of interlobular bile ducts; paucity of interlobular bile ducts (PILBD); pediatric; programs; recombinase; response; reverse transcriptase PCR; social role; transcription factor; transgenic",The Role of the Notch Pathway in Bile Duct Development,,71841,HBPP,Hepatobiliary Pathophysiology Study Section,S1,5,99998,
8007517,R01,DK,3,Y,01/15/2010,09/30/2010,PA-03-145,3R01DK071939-05S2,,NIDDK:98566;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MA, AVERIL I;",1876399;,3R01DK071939,01/15/2010,09/30/2010,"A Mouse; APF-1; ATP-Dependent Proteolysis Factor 1; Autoregulation; Bacteria; Biochemical; Cell Communication and Signaling; Cell Signaling; Cells; Data; Disease; Disorder; E3 Ligase; E3 Ubiquitin Ligase; Enzymes; Eukaryote; Eukaryotic Cell; Gene Targeting; Genetic; HMG-20; Hematopoietic; High Mobility Protein 20; Homeostasis; Immune; Immune response; In Vitro; Inflammatory Response; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Ligase; Link; MGC[{..}]3310; Mammals, Mice; Measures; Mediating; Mice; Modification; Murine; Mus; Myeloid Cells; Physiologic; Physiological; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; Proteins; Receptor Signaling; Regulation; Research Personnel; Researchers; SEQ-AN; Sequence Analyses; Sequence Analysis; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Specificity; Substrate Specificity; Synthetases; TLR protein; TNF Receptor-Associated Factor 6 Gene; TRAF6; TRAF6 gene; Targetings, Gene; Testing; Toll-like receptors; Transfection; Ubiquitin; Ubiquitin-Protein Ligase E3; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; biological signal transduction; bowel; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; host response; immunoresponse; in vitro Assay; in vivo; insight; microbial; mutant; novel; pathogen; prevent; preventing; programs; research study; response; ubiquitin-protein ligase",Ubiquitylation and the Regulation of Immune Homeostasis,,71939,ZRG1,Special Emphasis Panel,S2,5,98566,
8004335,R01,DK,3,Y,01/20/2010,12/31/2010,PA-04-092,3R01DK072011-05S1,,NIDDK:100141;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"KORNER, JUDITH ;",1931471;,3R01DK072011,01/20/2010,12/31/2010,"Adipose tissue; Affect; Appetite Regulation; Autoregulation; Blood Plasma; Blood Sample; Blood specimen; Body Composition; Body Weight; Body Weight decreased; Body fat; Bypass; Caloric Restriction; Cell Locomotion; Cell Migration; Cell Movement; Cellular Migration; Central Nervous System; Chemotherapy-Hormones/Steroids; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Development; Drug Therapy; Drug or chemical Tissue Distribution; Effects, Longterm; Endocrine Gland Secretion; Expenditure; Fasting; Fats; Fatty Tissue; Fatty acid glycerol esters; Foregut; GHN; GLP-1; Gastric Bypass; Goals; Growth Hormone; Growth Hormone 1; HPLC; Head and Neck, Thyroid; High Pressure Liquid Chromatography; Homeostasis; Hormonal; Hormones; Hunger; Individual; Intravenous Glucose Tolerance; Intravenous Glucose Tolerance Test; Investigation; Investigators; Leptin; Long-Term Effects; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Modality; Molecular; Motility; Motility, Cellular; NMR Imaging; NMR Tomography; Nervous System, CNS; Neuraxis; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nuclear Magnetic Resonance Imaging; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; PYY Peptide; Peptide YY; Pharmacotherapy; Physiological Homeostasis; Pituitary Growth Hormone; Plasma; Population; Primitive foregut structure; Procedures; Programs (PT); Programs [Publication Type]; Prospective Studies; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; STH; Satiation; Satiations; Serum, Plasma; Somatotropin; Stomach; System; System, LOINC Axis 4; Therapeutic Hormone; Thyroid; Thyroid Gland; Thyroid Gland Hormone; Thyroid Hormones; Tissue Distribution; Visceral; Weight; Weight Loss; Weight Reduction; Zeugmatography; adipose; bariatric surgery; body weight loss; calorie restriction; cell motility; experience; fasted; fasts; gastric; gastric banding; gastric bypass surgery; ghrelin; glucagon-like peptide 1; hGHN; implantable gastric stimulation banding; implantation; insulin sensitivity; intravenous glucose tolerance test; non-diabetic; nondiabetic; ob/ob mouse; obesity surgery; obesity treatment; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; programs; satiety; social role; somatotropic hormone; stomach bypass; stomach stapling; weight loss surgery; weight maintenance; white adipose tissue; wt-loss; yellow adipose tissue","Bariatric Surgery, Gastric Stimulation: Metabolic Effects",,72011,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,5,100141,
8004314,R01,DK,3,Y,01/10/2010,12/31/2010,DK-03-022,3R01DK072526-04S1,,NIDDK:99258;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"BERK, PAUL DAVID;",1867723;,3R01DK072526,01/10/2010,12/31/2010,"A1 protein; ACRP30 protein; ADD-1 protein; ADD1 protein; Abbreviations; Adipocytes; Adipose Cell; Adipose tissue; Anabolism; Animal Model; Animal Models and Related Studies; Animals; Apo A-1; Apo A-I; Apo A1; Apo AI; Apo-B; ApoA-1; ApoA-I; ApoB; Apolipoprotein A-1; Apolipoprotein A-I; Apolipoprotein A1; Apolipoprotein AI; Apolipoproteins; Apolipoproteins B; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B blood cells; B-Cells; B-Lymphocytes; Bariatrics; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biology; Blood; Blood Plasma; Blood Pressure, High; Blood Sample; Blood specimen; Body Weight decreased; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD36 protein; CETP; CETP gene; Carbohydrates; Cardiovascular Diseases; Catabolism; Cell Size; Cessation of life; Characteristics; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Esters; Cholesteryl Esters; Clinical; Comorbidity; Data; Death; Defect; Descriptor; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Dyslipidemias; EC 2; EC 2.3.1.85; Endocrine; Enzymes; Epidemic; Excretory function; Fasting; Fat Cells; Fats; Fatty Acid Metabolism Pathway; Fatty Acid Synthetase Complex; Fatty Liver; Fatty Tissue; Fatty acid glycerol esters; Fatty-acid synthase; Functional disorder; Gastrectomy; Gene Expression; Gene Products, RNA; Gene Targeting; Genes; Genetic; HDL; HDL lipoprotein triglyceride; HDL-triglyceride; Harvest; Heavy Lipoproteins; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; High Density Lipoproteins; High density lipoprotein; Human; Human, General; Humulin R; Hyperglyceridemia; Hyperlipemia; Hyperlipidemia; Hypertension; Hypertriglyceridemia; Infiltration; Inflammatory; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intra-abdominal; Investigators; Kinetic; Kinetics; LDL; Lead; Leptin; Ligand Binding Protein; Lipase; Lipocytes; Lipolysis; Lipoprotein Receptor; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Liver Cells; Liver Steatosis; Liver diseases; Low-Density Lipoproteins; METBL; MODY; MTP triglyceride carrier; Malabsorption Syndromes; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measurement; Medical; Messenger RNA; Metabolic Processes; Metabolic syndrome; Metabolism; Molecular Interaction; Morbid Obesity; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Movement; NAFLD; NASH; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-alcoholic steatohepatitis; Novolin R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Obesity, Morbid; Oleic Acids; Operation; Operative Procedures; Operative Surgical Procedures; Organism-Level Process; Organismal Process; Outcome; PPAR gamma; PPARG; PPARG1; PPARG2; PPARgamma; Pancreatic beta Cell; Pathogenesis; Pathway interactions; Patients; Pb element; Peroxisome Proliferative Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor gamma; Phosphatidyl Transfer Protein; Phospholipid Transfer Proteins; Physiologic Processes; Physiological Processes; Physiopathology; Plasma; Population; Prebeta-Lipoproteins; Procedures; Production; Programs (PT); Programs [Publication Type]; Protein Secretion; Proteins; Protocol; Protocols documentation; RF-C protein; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Raised TG; Raised triglycerides; Receptor Protein; Relative; Relative (related person); Research Personnel; Researchers; Response Elements; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Risk; Risk Factors; Rodent; Rodentia; Rodentias; SR-BI receptor; SREBP-1c; Sampling; Series; Serum, Plasma; Severe obesity; Severities; Source; Staging; Stearate Desaturase; Stearoyl-CoA Desaturase; Stearoyl-CoA,hydrogen-donor[{..}]oxygen oxidoreductase; Stearyl-CoA Desaturase; Stromal Cells; Structure of beta Cell of islet; Surgical; Surgical Interventions; Surgical Procedure; T2D; T2DM; Targetings, Gene; Testing; Therapeutic; Thiazolidinedione Receptor; Time; Transferase; Triacylglycerol; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triglyceride increased; Triglycerides; Triglycerides high; Triolean Hydrolase; Type 2 diabetes; Type II diabetes; VLDL; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Very low density lipoprotein; Weight Loss; Weight Reduction; abdominal adiposity; abdominal fat; activator 1 protein; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adipose; adiposity; adult onset diabetes; alpha-Lipoproteins; apM-1 protein; apM1 (adipose-specific) protein; atheromatosis; atherosclerotic vascular disease; bariatric surgery; beta-Lipoproteins; biopsy of liver; biosynthesis; body movement; body system, hepatic; body weight loss; cardiovascular disorder; corpulence; corpulency; corpulentia; cost; cytokine; delta-9 Desaturase; density; diabetes; elevated tg; elevated triglyceride; excretion; falls; fasted; fasts; fatty acid metabolism; fatty acid oxidation; gastric banding; gastric bypass surgery; gastrointestinal absorption disorder; gene product; heavy metal Pb; heavy metal lead; hepatic lipase; hepatic steatosis; hepatopathy; high risk; hyperpiesia; hyperpiesis; hypertensive disease; implantable gastric stimulation banding; insight; insulin resistant; interest; intestinal malabsorption; ketosis resistant diabetes; lipoprotein triglyceride; liver biopsy; liver disorder; long chain fatty acid; mRNA; mRNA Expression; macrophage; malabsorption; man; man's; maturity onset diabetes; microsomal TG transfer protein; microsomal triglyceride transfer protein; model organism; moderate obesity; new therapeutic target; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; novel; ob/ob mouse; obese; obese people; obese person; obese population; obesity surgery; obesity treatment; obesity, extreme; organ system, hepatic; oxidation; pancreas beta cell; pathophysiology; pathway; programs; receptor; replication factor C; response; scavenger receptor B type I; scavenger receptor B1; scavenger receptor BI; scavenger receptor class B type I; scavenger receptors, class B, type I; stomach stapling; subcutaneous; surgery; therapeutic target; transcription factor ADD1; tributyrase; uptake; weight loss surgery; white adipose tissue; wt-loss; yellow adipose tissue",Bariatric Surgery for Morbid Obesity: Clinical and Pathophysiologic Consequences,,72526,ZDK1,Special Emphasis Panel,S1,4,99258,
7996294,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK073368-04S2,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ZHANG, JIN ;",8059892;,3R01DK073368,01/15/2010,03/31/2010,"2'-AMP; 2'-adenosine monophosphate; 2'-adenylic acid; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; 3T3-L1 Cells; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adipocytes; Adipose Cell; Adrenergic Agents; Adrenergic Drugs; Adrenergic Receptor; Adrenergics; Adrenoceptors; Apoptosis; Apoptosis Pathway; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Caveolae; Caveolas; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chronic; Clinical; Coupling; Cyclic AMP; Cytoplasm; Cytoplasmic Membrane; Data; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diffusion; Embryo; Embryonic; Engineering; Engineerings; Fat Cells; Generations; Genetic Engineering of Proteins; Goals; Guanosine; Human; Human, General; Humulin R; Image; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Kidney; Knowledge; Laboratories; Lead; Learning; Life; Linkage Analysis; Lipocytes; METBL; MODY; Mammalian Cell; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Mitochondria; Molecular; Monitor; NIDDM; Nature; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; PDE; Pattern; Pb element; Phosphodiesterases; Plasma Membrane; Production; Protein Engineering; Protein Kinase; Proteins; Receptors, Epinephrine; Regulation; Research; Research Personnel; Researchers; Role; Second Messenger Systems; Second Messengers; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Subcellular Process; T2D; T2DM; Techniques; Testing; Therapeutic; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; adenoreceptor; adenosine 3'5' monophosphate; adenylcyclase; adiposity; adrenergic; adult onset diabetes; beta-adrenergic receptor; biological signal transduction; cAMP; corpulence; corpulency; corpulentia; family based linkage study; fluorescence imaging; gene product; genetic linkage analyses; genetic linkage analysis; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; imaging; innovate; innovation; innovative; ketosis resistant diabetes; linkage analyses; maturity onset diabetes; mitochondrial; obese; obese people; obese person; obese population; phosphoric diester hydrolase; phosphorylase b kinase kinase; plasmalemma; renal; second messenger; social role; spatiotemporal",Mechanisms of Compartmentalized cAMP Signaling,,73368,SBCB,Synthetic and Biological Chemistry B Study Section,S2,4,100000,
8010041,R01,DK,3,Y,01/18/2010,12/31/2010,PA-03-150,3R01DK073391-03S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,BIOCHEMISTRY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"TOWNES, TIM M.;",1880423;,3R01DK073391,01/18/2010,12/31/2010,"21+ years old; Adult; Affinity; Affinity Chromatography; B-globin; B-thalassemia; Binding; Binding (Molecular Function); Binding Proteins; Body Tissues; Bone Marrow; Boxing; Cells; Chromatography, Affinity; Complex; Development; Distal; Embryo; Embryonic; Erythroid; Erythroid Cells; Female; Fetal Liver; Foundations; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; General Transcription Factor Gene; Genes; Genes, Switch; Globin; Hb SS disease; HbSS disease; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hemoglobinopathies; Hemoglobinopathies / Iron Metabolism; Human; Human, Adult; Human, General; Investigators; Knockout Mice; Learning; Ligand Binding Protein; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Methods; Mice; Mice, Knock-out; Mice, Knockout; Minor; Modeling; Modification; Molecular Interaction; Murine; Mus; Null Mouse; Partner in relationship; Patients; Photometry/Spectrum Analysis, Mass; Play; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proto-Oncogene, Transcription Factor; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Sickle Cell Anemia; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Switch Genes; Testing; Thalassemia Major; Tissues; Transcription factor genes; Yolk Sac; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adult human (21+); affinity purification; beta Globin; beta Thalassemia; design; designing; experiment; experimental research; experimental study; fetal globin; gene product; in vivo; insight; male; mate; novel; p-Globin; p-Thalassemia; primitive cell; programs; protein complex; research study; sickle cell disease; sickle disease; sicklemia; social role; transcription factor; vitelline sac",Erythroid Krupple-Like Factor Complexes Defined in TAP-Tagged Knockin Mice,,73391,ELB,Erythrocyte and Leukocyte Biology Study Section,S1,3,100000,
7996771,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK073414-03S2,,NIDDK:39270;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PATHOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"CHANG, CHAWNSHANG ;",7688996;,3R01DK073414,01/15/2010,03/31/2010,"Ablation; Affect; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Apoptosis; Apoptosis Pathway; Apoptotic; Arthritis; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; Blood Serum; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Death, Programmed; Cell Isolation; Cell Lineage; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen; Cytofluorometry, Flow; Development; Disease; Disorder; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gene Products, RNA; Generations; Genes; Genotype; Gonadal Steroid Hormones; Immune; In Vitro; Inflammatory Response; Knock-out; Knockout; Knockout Mice; Link; Lymphopoiesis; Male Castration; Mammals, Mice; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Murine; Mus; Null Mouse; Pathway interactions; Play; Predisposition; Production; Proliferating; RNA; RNA, Non-Polyadenylated; Regulation; Resistance; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Role; Serum; Sex Hormones; Sex Steroid Hormones; Site; Stromal Cells; Susceptibility; Testing; Therapeutic Androgen; Wild Type Mouse; antibody biosynthesis; arthritic; autoimmune antibody; autoimmune disorder; cell sorting; disease/disorder; flow cytophotometry; gonadal steroids; immunoglobulin biosynthesis; in vivo; lymphocytopoiesis; male; pathogen; pathway; peripheral blood; precursor cell; resistant; self reactive antibody; self recognition (immune); sex steroid; social role",Androgen Receptor in B Cell Development and Functions,,73414,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S2,3,39270,
7998878,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK073446-05S2,,NIDDK:57413;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW ORLEANS,UNITED STATES,,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"SHELINE, CHRISTIAN THOMAS;",1936080;,3R01DK073446,01/15/2010,03/31/2010,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 3-Pyridinecarboxamide; ADP ribosylation; ADP-Ribosyltransferase (Polymerizing); Active Oxygen; Acute; Adenoma, beta-Cell; Affect; Age; Animal Model; Animal Models and Related Studies; Animals; Animals, Genetically Modified; Attenuated; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; B9 endocrine pancreas; Back; Backcrossings; Beta Cell; Beta Cell Neoplasm; Beta Cell Neoplasm of the Pancreas; Beta Cell Tumor of the Pancreas; Binding; Binding (Molecular Function); Blood Glucose; Blood Sugar; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Catabolism; Cause of Death; Cell Death; Cells; Cessation of life; Chelating Agents; Chelators; Chemosensitization; Chemosensitization/Potentiation; Complexons; Death; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Dorsum; Dose; Dysfunction; Enzymes; Functional disorder; GMO Animals; Gastrointestinal Tract, Pancreas; Genetic; Genetically Modified Animals; Human; Human, General; Humulin R; IDD; IDDM; In Situ; In Vitro; Inbred NOD Mice; Incidence; Injection of therapeutic agent; Injections; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Insulin-Producing Neoplasm of the Islet Cells; Insulin-Producing Tumor of the Islet Cells; Insuloma; Intermediary Metabolism; Investigators; Islands of Langerhans; Islet Cell; Islet Cells; Islets of Langerhans; Knock-out; Knockout; METBL; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Inbred NOD; Mitochondria; Modeling; Molecular Interaction; Mouse, NOD; Murine; Mus; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Nesidioblasts; Neural Cell; Neurocyte; Neurons; Niacinamide; Nicotinamide; Nicotinamidum; Nicotinic acid amide; Nicotylamide; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; Oxidation-Reduction; Oxygen Radicals; PARP Polymerase; PARS; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Beta Cell Insulin Producing Neoplasm; Pancreatic Beta Cell Insulin Producing Tumor; Pancreatic Beta Cell Tumor; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Pellagra-Preventing Factor; Physiologic; Physiological; Physiopathology; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Potentiation; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Protein Deacetylases, NAD-Dependent; Proteins; Pyruvate; Pyruvates; Reactive Oxygen Species; Redox; Research Personnel; Researchers; Role; Route; STZ; Secretory Granules; Secretory Vesicles; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Deacetylases; Sir2-like Proteins; Sirtuins; Staining method; Stainings; Stains; Streptozocin; Streptozotocin; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Type 1 diabetes; Vitamin B 3; Vitamin B3; Vitamin PP; Work; Zanosar; Zinc; Zn element; autoimmune disorder; beta cell development; beta-Cell Tumor; biological adaptation to stress; cofactor; cytokine; density; diabetes; diabetic; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; extracellular; gene product; genetic manipulation; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; insulin dependent diabetes; insulinoma; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; member; mitochondrial; model organism; necrocytosis; neuron toxicity; neuronal; neuronal toxicity; neurotoxicity; new therapeutics; next generation therapeutics; novel; novel therapeutics; overexpression; oxidation reduction reaction; pathophysiology; pathway; physiologic model; poly ADP polymerase; poly ADP ribose synthetase; prevent; preventing; programs; prophylactic; protective effect; pyridine; reaction; crisis; research study; response; self recognition (immune); sirtinol; social role; stress response; stress; reaction; synthetic enzyme; thymus derived lymphocyte; type I diabetes; uptake; zinc binding ligand; zinc transporter; zinc-binding protein",Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By Sirtuin-Mediated NAD+ Loss,,73446,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S2,5,57413,
8006720,R01,DK,3,Y,01/08/2010,12/31/2010,,3R01DK073632-04S2,,NIDDK:151979;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"AZZIZ, RICARDO ;",1863703;,3R01DK073632,01/08/2010,12/31/2010,"1-Phosphatidylinositol 3-Kinase; 2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; 70-kDa Ribosomal Protein S6 Kinases; A kinase anchoring protein; ADRGND; AKAP; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Abdomen; Abdominal; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adipocytes; Adipose Cell; Adipose tissue; Adrenal Glands; Adrenals; Affect; Age; Akt protein; Androgenic Agents; Androgenic Compounds; Androgens; Basic Research; Basic Science; Binding; Binding (Molecular Function); Binding Proteins; Biopsy; Blotting, Western; Body Tissues; C protein; CBP protein (citrate-binding); CSBP1; CSBP2; CSPB1; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Causality; Cell Communication and Signaling; Cell Signaling; Clinical; Collaborations; Consult; Critical Paths; Critical Pathways; Cyclic AMP-Dependent Protein Kinases; D-arabino-Hexose, 2-deoxy-; Data; Defect; Deoxyglucose; Disease; Disorder; Dual Specificity Mitogen-Activated Protein Kinase Kinase 1; ERK Activator Kinase 1; EXIP; Economic Burden; Endocrinologist; Etiology; Extracellular Signal-Regulated Kinase Gene; FKH1; FKHR; FOXO1A; FOXO1A gene; FRAT1; FRAT1 gene; Fat Cells; Fatty Tissue; Funding; Future; GSK-3; Glycogen Synthase Kinase 3; Hormonal; Humulin R; Hyperandrogenism; Hyperinsulinemia; Hyperinsulinism; INSR; IRS-1 protein; IRS1; In Vitro; Infrastructure; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Receptor Substrate 1; Insulin Resistance; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Intravenous Glucose Tolerance; Intravenous Glucose Tolerance Test; Investigators; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; L-Serine; L-Tyrosine; Laboratories; Length of Life; Ligand Binding Protein; Lipocytes; Longevity; Longitudinal Studies; MAP Kinase 8; MAP Kinase 8 Gene; MAP Kinase Gene; MAP kinase kinase 1, human; MAP2K1 Protein; MAP2K1 protein, human; MAPK; MAPK/ERK Kinase 1; MAPK14; MAPK14 gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MEK-1; MEK-1 protein, human; MEK1 protein, human; MKK-1 protein, human; MKK1 protein, human; Mature Lipocyte; Mature fat cell; Mediating; Metabolic; Methods and Techniques; Methods, Other; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinase Kinase-1; Molecular; Molecular Interaction; Mxi2; Nature; Needles; Novolin R; Ovarian; PCR; PI-3 Kinase; PI-3K; PI3-Kinase; PKA; PKB protein; PKC; PRKM14; PRKM15; PRKM8; Pathway interactions; Patients; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Physiology; Play; Polycystic Ovarian Disease; Polycystic Ovary Syndrome; Polymerase Chain Reaction; Population; Procedures; Programs (PT); Programs [Publication Type]; Protein Kinase A; Protein Kinase B; Protein Kinase C; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; PtdIns 3-Kinase; RAC-PK protein; Race; Racial Group; Receptor Signaling; Recruitment Activity; Regulation; Relative; Relative (related person); Research; Research Infrastructure; Research Personnel; Researchers; Reverse Transcription; Ribosomal Protein S6 Kinases, 70-kDa; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SAPK2A; Sampling; Scientist; Sclerocystic Ovarian Degeneration; Sclerocystic Ovary Syndrome; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stein Lenventhal syndrome; Stein-Leventhal Syndrome; Steroid biosynthesis; Stocks, Racial; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Study Subject; Surgeon; TYR; Techniques; Testing; Therapeutic Androgen; Time; Tissue Sample; Tissues; Transfection; Translations; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine; Tyrosine, L-isomer; Up-Regulation; Up-Regulation (Physiology); Upregulation; Western Blotting; Western Blottings; Western Immunoblotting; Woman; adenoviral-mediated; adipose; biological signal transduction; c-akt protein; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cAMP-Dependent Protein Kinases; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experience; experiment; experimental research; experimental study; gene product; glucose transport; glucose uptake; gsk-3 Gene Product; human MAP2K1 protein; in vitro Model; in vitro activity; in vivo; inhibitor; inhibitor/antagonist; insulin receptor substrate 1 protein; insulin resistant; insulin signaling; intravenous glucose tolerance test; jun-NH2-Terminal Kinase; life span; lifespan; long-term study; mitogen-activated protein kinase kinase 1, human; molecular marker; novel; p38; p38 MAPK Gene; p38Alpha; p70 S6 Kinase; p70s6k; para-Tyrosine; pathway; polycystic ovary; polycystic ovary disease; polycystic ovary disorder; programs; protein blotting; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; receptor binding; recruit; related to A and C-protein; reproductive; research study; response; skills; social role; steroidogenesis; stress-activated protein kinase 1; subcutaneous; suprarenal gland; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; uptake; white adipose tissue; yellow adipose tissue",INSULIN SIGNALING DEFECTS IN PCOS,,73632,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S2,4,151979,
8012053,R01,DK,3,Y,01/20/2010,12/31/2010,,3R01DK073641-04S1,,NIDDK:100001;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MILWAUKEE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"CIRILLO, LISA A;",1875755;,3R01DK073641,01/20/2010,12/31/2010,"Activation, Gene; Address; Albumins; Anaplastic; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Cancers; Cell Differentiation; Cell Differentiation process; Cells; Chromatin; Chromatin Structure; Combining Site; DNA Binding; DNA Binding Interaction; DNA Endonuclease; DNase; DNase I; Deoxyribonuclease I; Development; Diabetes Mellitus; Disease; Disorder; Embryo; Embryonic; Endoderm; Enhancers; Environment; Enzymes; Event; Gene Activation; Gene Transcription; Genes; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Grant; Growth and Development; Growth and Development function; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Histones; Human; Human, General; In Vitro; Intermediary Metabolism; Investigators; Liver; Liver Cells; Liver diseases; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mediating; Metabolic Processes; Metabolism; Modification; Molecular; Molecular Interaction; Mutate; Mutation; Neoplasms; Nucleosomes; Pancreatic DNase; Play; Position; Positioning Attribute; Procedures; Proteins; RNA Expression; Reactive Site; Regulator Genes; Research Design; Research Personnel; Researchers; Role; Site; Specific qualifier value; Specified; Study Type; System; System, LOINC Axis 4; Testing; Thymonuclease; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Tumors; Undifferentiated; body system, hepatic; chromatin remodeling; diabetes; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; hepatopathy; in vivo; insight; liver disorder; malignancy; neoplasia; neoplasm/cancer; neoplastic growth; novel; organ system, hepatic; reconstitute; reconstitution; regulatory gene; research study; social role; study design; trans acting element; transcription factor",Chromatin Remodeling During Liver Development,,73641,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,S1,4,100001,
8006951,R01,DK,3,Y,01/10/2010,12/31/2010,,3R01DK073671-04S1,,NIDDK:61523;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"SILBER, JEFFREY H;",1870069;,3R01DK073671,01/10/2010,12/31/2010,"Abscess; Absence of pain sensation; Absence of sensibility to pain; Address; Affect; Aged 65 and Over; Analgesia, Epidural; Anastomosis; Anastomosis - action; Anesthesia; Anesthesia procedures; Anesthesia, Conduction; Anesthesia, Epidural; Anesthesia, Extradural; Anesthesia, Peridural; Anesthesia, Regional; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, Intravenous; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Apnea, Sleep; Aspiration, Respiratory; Blood Loss, Postoperative; Blood Serum; Blood Vessels; Breathing; Caring; Catheters; Causality; Cessation of life; Characteristics; Claims Analyses; Claims Analysis; Claims Review; Clinical; Clinical Data; Communities; Conduction Anesthesia; D-Glucose; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Deep Vein Thrombosis; Deep-Venous Thrombosis; Development; Dextrose; Diagnosis; Early Ambulation; Elderly; Elderly, over 65; Epidural Analgesia; Epidural Anesthesia; Epidural Block; Etiology; FLR; Failure (biologic function); Feels no pain; Glucose; Guidelines; HOSP; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Height; Hospital Readmission; Hospitals; Individual; Infrastructure; Inhalation; Inhaling; Inspiration, Respiratory; Institution; Insurance Claim Review; Intravenous Anesthetics; Investigators; Length of Stay; Literature; Measures; Medical; Medicare; Medicare claim; Methods and Techniques; Methods, Other; Miscellaneous Antibiotic; Monitor; Mortality; Mortality Vital Statistics; No sensitivity to pain; Non obese; Nonobese; Number of Days in Hospital; Nursing Records; Obesity; Operation; Operative Procedures; Operative Surgical Procedures; Opiates; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Ostomy; Outcome; Outcome Study; Pain; Pain Control; Pain Therapy; Pain management; Pain, Postoperative; Painful; Patient Care; Patient Care Delivery; Patients; Pattern; Perioperative; Perioperative Care; Play; Pneumonia; Pneumonitis; Population; Post-Operative; Post-Operative Hemorrhage; Post-operative Pain; Postoperative; Postoperative Bleeding; Postoperative Hemorrhage; Postoperative Pain; Postoperative Period; Predictive Factor; Probability; Procedures; Programs (PT); Programs [Publication Type]; Pulmonary Embolism; Pulmonary Inflammation; QOL; Quality of life; Relative; Relative (related person); Research Infrastructure; Research Personnel; Researchers; Respiratory Depression; Rhabdomyolysis; Risk; Risk Factors; Role; Serum; Serum Albumin; Sleep Apnea Syndromes; Sleep Hypopnea; Sleep-Disordered Breathing; Study, Outcome; Surgical; Surgical Interventions; Surgical Procedure; Tail; Techniques; Technology; Testing; Time; Time Study; Title 18; Treatment outcome; Ventilatory Depression; Weight; Work; adiposity; advanced age; analgesia; base; clinical care; clinical data repository; clinical data warehouse; cohort; corpulence; corpulency; corpulentia; cost; data repository; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; dosage; elderly patient; elders; failure; geriatric; health insurance for disabled; hospital days; hospital length of stay; hospital stay; improved; inspiration; late life; later life; obese; obese people; obese person; obese population; older adult; older patient; older person; prevent; preventing; primary outcome; programs; relational database; secondary outcome; senior citizen; social role; surgery; surgical construction of a stoma; urologic; urological; vascular",Obesity and Surgical Outcomes,,73671,ZRG1,Special Emphasis Panel,S1,4,61523,
7998881,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK073681-04S1,,NIDDK:29975;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"TOMER, YARON ;",1977061;,3R01DK073681,01/15/2010,03/31/2010,"APC; Adoptive Transfer; Affinity; Amino Acids; Antigen-Presenting Cells; Approaches to prevention; Arginine; Arginine, L-Isomer; Autoimmune Diseases; Autoimmune thyroiditis; Basedow's Disease; Binding; Binding (Molecular Function); Bio-Informatics; Biochemical; Bioinformatics; Bp50; CD40; CDW40; Cathepsins; Causality; Cell Culture Techniques; Cells; Charge; Chronic Lymphocytic Thyroiditis; Cleaved cell; Complex; Computer Simulation; Computerized Models; Cross-Product Ratio; Data; Development; Diathesis; Disease; Disease susceptibility; Disorder; Etiology; Exons; Genes; Genetic; Gln; Glutamine; Goals; Goiter, Exophthalmic; Graves' Disease; HLA-BR; HLA-BR Antigens; HLA-D-Related Antigens; HLA-DR; HLA-DR Antigens; HLA-DR3; HLA-DR3 Antigen; HLA-MT; HLA-MT Antigens; Hashimoto Disease; Hashimoto's Disease; Hashimoto's Struma; Hashimoto's Thyroiditis; Hashimoto's syndrome; Hashimotos Disease; Human; Human, General; Immunization; Immunogenetic; Immunogenetics; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Knowledge; L-Arginine; L-Glutamine; Lead; Ligands; MGC9013; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Mice; Mice, Transgenic; Modeling; Models, Computer; Models, Molecular; Molecular; Molecular Interaction; Molecular Models; Monocytes / Macrophages / APC; Murine; Mus; Nucleic Acid Biochemistry, Molecular Modeling; Odds Ratio; Pathogenesis; Pathogenicity; Patients; Pb element; Peptide Fragments; Peptides; Photometry/Spectrum Analysis, Mass; Play; Polymorphism, Single Base; Position; Positioning Attribute; Predisposition; Prevention approach; Protein/Amino Acid Biochemistry, Molecular Modeling; Q. Levoglutamide; Receptors, Antigen, T-Cell; Relative Odds; Resistance; Risk Ratio; Role; SNP; SNPs; Sensitization, Immunologic; Sensitization, Immunological; Simulation, Computer based; Single Nucleotide Polymorphism; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splenocyte; Susceptibility; T-Cell Receptor; T-Cells; T-Lymphocyte; TNFRSF5; TNFRSF5 gene; Testing; Thymus-Dependent Lymphocytes; Thyroglobulin; Thyroiditis; Thyroiditis, Lymphocytic; Thyroiditis, Lymphomatous; Transgenic Mice; Transgenic Organisms; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Variant; Variation; accessory cell; aminoacid; autoimmune disorder; autoimmune thyroid disease; autoimmune thyroid disorder; base; cleaved; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disease/disorder proneness/risk; disorder etiology; experiment; experimental research; experimental study; genetic variant; heavy metal Pb; heavy metal lead; immunogenic; in silico; in vivo; intervention development; knowledge base; liability to disease; molecular modeling; novel; p50; research study; resistant; response; social role; therapy development; thymus derived lymphocyte; transgenic; treatment development; virtual simulation",Thyroglobulin Peptide Presentation by HLA-DR in Thyroiditis,,73681,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,S1,4,29975,
8009196,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK074270-04S1,,NIDDK:89928;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAMPAIGN,UNITED STATES,ANATOMY/CELL BIOLOGY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"FREEMAN, BRIAN C;",1894228;,3R01DK074270,02/01/2010,04/30/2010,"ATP phosphohydrolase; ATPase; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Assay; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Blood Pressure, High; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chaperone; Chemotherapy-Hormones/Steroids; Complex; DNA Binding; DNA Binding Interaction; DNA-Dependent RNA Polymerase II; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Disease; Disorder; Dissociation; EC 2.7.7.6; Endocrine Gland Secretion; Engineering; Engineerings; Equilibrium; Esthesia; Event; Fluorescence; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genetic Transcription; Genomics; Goals; Health; Hormone Receptor; Hormones; Hypertension; INFLM; In Vitro; Inflammation; Intracellular Communication and Signaling; Kinetic; Kinetics; Lead; Life; Ligands; Malignant Neoplasms; Malignant Tumor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Molecular; Molecular Chaperones; Molecular Interaction; Monitor; Nuclear; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Pathway interactions; Pb element; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA Polymerases; RNA, Messenger; Reaction Time; Receptor Protein; Receptor Signaling; Recruitment Activity; Regulation; Response Elements; Response RT; Response Time; Role; Run-On Assays; Sensation; Series; Signal Transduction; Signal Transduction Systems; Signaling; Structure; TFIIF; Testing; Therapeutic Agents; Therapeutic Hormone; Transcript; Transcription; Transcription, Genetic; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Withdrawal; balance; balance function; biological signal transduction; cofactor; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; insight; mRNA; malignancy; mutant; neoplasm/cancer; pathway; psychomotor reaction time; receptor; recruit; research study; response; scaffold; scaffolding; social role; transcription factor; transcription factor TFIIF",Dynamic signaling by intracellular hormone receptors,,74270,MCE,Molecular and Cellular Endocrinology Study Section,S1,4,89928,
8010760,R01,DK,3,Y,01/18/2010,12/31/2010,PA-04-125,3R01DK074482-04S1,,NIDDK:99999;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"TRAVER, DAVID ;",1899492;,3R01DK074482,01/18/2010,12/31/2010,"21+ years old; Adult; Aorta; Behavior; Binding; Binding (Molecular Function); Biological Models; Birth; Blood; Blood Cells; Blood Precursor Cell; Body Tissues; Brachydanio rerio; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Function; Cell Lineage; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complement; Complement Proteins; Cytofluorometry, Flow; DISSEC; Danio rerio; Daughter; Development; Dissection; Electromagnetic, Laser; Embryo; Embryonic; Emigrations; Environment; Event; Expression Profiling; Expression Signature; FISH Technic; FISH Technique; FISH analysis; Fetus; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescent in Situ Hybridization; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene Transfer Techniques; Gene-Tx; Generalized Growth; Generations; Genes; Genetic; Genetic Intervention; Gonadal structure; Gonads; Growth; Hematologic Body System; Hematopoietic; Hematopoietic Body System; Hematopoietic System; Hematopoietic stem cells; Human, Adult; Image; Immigrations; In Situ Hybridization, Fluorescence; In Vitro; In-Migration; Individual; Intervention, Genetic; Intracellular Communication and Signaling; Investigators; Kidney; Label; Lasers; Life; Maps; Marrow; Mesonephric structure; Mesonephros; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Microscopy; Model System; Models, Biologic; Molecular; Molecular Biology, Gene Therapy; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Mother Cells; Organ System, Hematologic; Parturition; Patients; Pattern; Peripheral Blood Cell; Population; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Pronephric structure; Pronephros; Radiation, Laser; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Blood; Route; Signal Transduction; Signal Transduction Systems; Signaling; Stem Cell Development; Stem cells; Subcellular Process; System; System, LOINC Axis 4; Techniques; Technology; Testing; Therapy, DNA; Time; Tissue Growth; Tissues; Transgenes; Transgenesis; Transgenic Animals; Transgenic Organisms; Translating; Translatings; Translations; Transplantation; Travel; Urinary System, Kidney; Wolffian Body; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); biological signal transduction; experiment; experimental research; experimental study; flow cytophotometry; gene therapy; genetic therapy; hESC; human ES cell; human ESC; human embryonic stem cell; imaging; in utero; in vivo; insight; language translation; migration; molecuar profile; molecular signature; mutant; novel; ontogeny; programs; prospective; renal; research study; self-renewal; spatiotemporal; stem cell fate specification; stem cell niche; stem cell population; transgenic; transplant",Molecular and functional dissection of zebrafish hematopoietic stem cell niche,,74482,HP,Hematopoiesis Study Section,S1,4,99999,
7998873,R01,DK,3,Y,01/15/2010,12/30/2010,,3R01DK074656-05S1,,NIDDK:113146;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GAINESVILLE,UNITED STATES,PATHOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"MATHEWS, CLAYTON E;",2242188;,3R01DK074656,01/15/2010,12/30/2010,"2,4,5,6(1H,3H)-Pyrimidinetetrone; Accounting; Address; Adoptive Transfer; Alleles; Allelomorphs; Alloxan; Amino Acids; Animal Model; Animal Models and Related Studies; Apoptotic; Attention; Autoimmune; Autoimmune Diabetes; Autoimmune Process; B blood cells; B-Cells; B-Lymphocytes; B9 endocrine pancreas; Beta Cell; Breeding; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Candidate Disease Gene; Candidate Gene; Cell Death; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Communication; Complex; Cytochrome c Reductase; D-Glucose; DNA, Mitochondrial; Death; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Diaphorase (NADH Dehydrogenase); Free Radicals; Functional impairment; Future; Gastrointestinal Tract, Pancreas; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Glucose; Goals; Histocompatibility Complex; Histocompatibility Complices; Human; Human, General; Humulin R; IDD; IDDM; Immune; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intermediary Metabolism; Islands of Langerhans; Islet Cells; Islets of Langerhans; Killings; L-Leucine; Laboratories; Leucine; Leucine, L-Isomer; Life; Link; METBL; MODY; Major Histocompatibility Complex; Major Histocompatibility Complices; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic Processes; Metabolism; Mice; Mitochondria; Mitochondrial DNA; Mouse Strains; Murine; Mus; Mutation; NADH (Acceptor) Oxidoreductase; NADH Cytochrome c Oxidoreductase; NADH Cytochrome c Reductase; NADH Dehydrogenase; NIDDM; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nuclear; Nucleus; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pedigree; Play; Polymorphism, Single Base; Population; Predisposition; Production; Reporting; Research Design; Resistance; Risk; Role; SNP; SNPs; Single Nucleotide Polymorphism; Source; Stimulus; Stress; Study Type; Subcellular Process; Susceptibility; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; T2D; T2DM; Testing; Thymus-Dependent Lymphocytes; Type 1 diabetes; Type 2 diabetes; Type II diabetes; Variant; Variation; Work; adult onset diabetes; aminoacid; beta cell development; cohort; cytokine; diabetes; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; free radical oxygen; functional disability; gain of function; genetic analysis; genetic pedigree; genome mutation; insulin dependent diabetes; insulin secretion; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; maturity onset diabetes; mitochondrial; mitochondrial DNA mutation; model organism; mtDNA; mtDNA mutation; necrocytosis; pedigree structure; prevent; preventing; progenitor; research study; resistant; social role; study design; thymus derived lymphocyte; type I diabetes",mt-Nd2 and Resistance to Autoimmune Diabetes,,74656,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",S1,5,113146,
8009175,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK074967-03S1,,NIDDK:82284;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"BROWN, MYLES A;",1945116;,3R01DK074967,02/01/2010,04/30/2010,"Address; Assay; Base Sequence; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Breast Cancer Cell; CHIP assay; Cancer of Breast; ChIP (chromatin immunoprecipitation); Chromosome 21; Chromosomes; Chromosomes, Human; Chromosomes, Human, Pair 21; Combining Site; Custom; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; Data; Development; Distant; Down-Regulation; Down-Regulation (Physiology); Downregulation; Enhancers; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Products, RNA; Gene Targeting; Genes; Genome; Genome, Human; Genomics; Human Breast Cancer Cell; Human Chromosomes; Human Genome; Investigators; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Malignant Tumor of the Breast; Malignant neoplasm of breast; Maps; Messenger RNA; Methods; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Nucleic Acid Regulatory Sequences; Nucleotide Sequence; ORFs; Oligonucleotide Array; Oligonucleotide Microarrays; Open Reading Frames; Pathologic; Physiologic; Physiological; Physiology; Play; Pol II; Production; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Protein Coding Region; Publishing; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Reactive Site; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Repetitive Element; Repetitive Regions; Repetitive Sequence; Research Personnel; Researchers; Response Elements; Ribonucleic Acid; Role; Site; Targetings, Gene; Testing; Therapeutic Estrogen; Transcript Expression Analyses; Transcript Expression Analysis; Transcription Initiation Site; Transcription Start Site; Up-Regulation; Up-Regulation (Physiology); Upregulation; base; chromatin immunoprecipitation; conformation; conformational state; density; design; designing; genetic regulatory element; genome-wide; mRNA; malignant breast neoplasm; nucleic acid sequence; programs; receptor binding; receptor function; social role; transcription factor",Comprehensive Analysis of Estrogen Receptor Genomic Action,,74967,MCE,Molecular and Cellular Endocrinology Study Section,S1,3,82284,
8000721,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK075013-03S2,,NIDDK:154586;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WAGNER, DAVID H;",1884695;,3R01DK075013,01/15/2010,12/31/2010,"ATGN; Address; Affect; Age; Antigens; Assay; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Bioassay; Biologic Assays; Biological Assay; Bp50; CD154; CD154 Antigens; CD40; CD40 Ligand; CD40-L; CD40L; CD40LG; CDW40; Cells; DNA Recombination; DNA recombination (naturally occurring); Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Disease; Disease model; Disorder; Event; Gastrointestinal Tract, Pancreas; Generations; Genetic Recombination; Goals; Grant; HIGM1; Haplotypes; Human; Human, General; Hyperglycemia; IDD; IDDM; IMD3; In Vitro; Inbred NOD Mice; Insulin-Dependent Diabetes Mellitus; Kinetic; Kinetics; Laboratories; Light; MGC9013; MHC Receptor; MODY; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Maturity-Onset Diabetes Mellitus; Mediating; Memory; Mice; Mice, Inbred NOD; Mice, Transgenic; Modeling; Mouse Strains; Mouse, NOD; Murine; Mus; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Ovalbumin; Pancreas; Pancreatic; Peripheral; Phenotype; Photoradiation; Play; Population; Prevention; Process; Receptor Cell; Receptors, Antigen, T-Cell; Recombination; Recombination, Genetic; Risk; Role; Source; Specificity; System; System, LOINC Axis 4; T Cell Specificity; T-B Cell Activating Molecule; T-Cell Activation; T-Cell Immunologic Specificity; T-Cell Receptor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T1 diabetes; T1D; T1DM; T2D; T2DM; TNF-Related Activation Protein; TNFRSF5; TNFRSF5 gene; TNFSF5; TNFSF5 gene; TRAP Gene; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Transgenic Mice; Translating; Translatings; Tumor Necrosis Factor Ligand Superfamily Member 5; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Type 1 diabetes; Type 2 diabetes; Type II diabetes; adult onset diabetes; autoimmune disorder; design; designing; diabetes; disease/disorder; disorder model; experiment; experimental research; experimental study; gp39; gp39 Antigen, T-Cell; human disease; hyperglycemic; immunogen; in vivo; in vivo Model; insulin dependent diabetes; insulin dependent diabetes mellitus onset; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; language translation; maturity onset diabetes; non-diabetic; nondiabetic; p50; prevent; preventing; receptor expression; research study; response; self recognition (immune); social role; thymus derived lymphocyte; type I diabetes",CD40-Induced TCR Revision: A Mechanism for Autoimmunity,,75013,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",S2,3,154586,
8009985,R01,DK,3,Y,01/15/2010,12/31/2010,,3R01DK075035-04S1,,NIDDK:165589;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLOTTESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"LE, THU H;",6488209;,3R01DK075035,01/15/2010,12/31/2010,"Albuminuria; Area; Blood Pressure; Blood Pressure, High; Candidate Disease Gene; Candidate Gene; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Chromosome Mapping; Chronic Kidney Failure; Chronic Kidney Insufficiency; Chronic Renal Disease; Cohort Studies; Concurrent Studies; Congenic Mice; Congenic Strain; Development; Disease Progression; ESRD; End stage renal failure; End-Stage Kidney Disease; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; General Population; General Public; Generations; Genes; Genetic; Genetics, Gene Mapping; Goals; Haplotypes; Heart Hypertrophy; Heart failure; Human; Human, General; Hypertension; Hypertrophy, Left Ventricular; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Kidney Diseases; Kidney Failure; Kidney Failure, Chronic; Kidney Insufficiency; Left Ventricular Hypertrophy; Link; Linkage Mapping; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Congenic; Modeling; Molecular; Mouse Strains; Murine; Mus; Myocardial Ischemia; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Nature; Nephrectomy; Nephropathy; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Patients; Pattern; Predisposition; Predisposition gene; Prevalence; Programs (PT); Programs [Publication Type]; Proteinuria; QTL; Quantitative Trait Loci; Recombinants; Renal Disease; Renal Disease, End-Stage; Renal Failure; Renal Failure, Chronic; Renal Insufficiency; Renal Insufficiency, Chronic; Research Personnel; Researchers; Resistance; Risk Factors; SEQ-AN; Sequence Analyses; Sequence Analysis; Series; Severities; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; Susceptibility Gene; Techniques; Testing; Therapeutic Intervention; Validation; Variant; Variation; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; base; cardiac failure; cardiac hypertrophy; cardiovascular disorder; cardiovascular risk; cardiovascular risk factor; chronic kidney disease; circulatory system; congenic; gene function; genetic mapping; genetic variant; heart ischemia; hyperpiesia; hyperpiesis; hypertensive disease; insight; intervention therapy; kidney disorder; mRNA Expression; mouse model; myocardial ischemia/hypoxia; myocardium ischemia; novel; positional cloning; predisposing gene; programs; renal disorder; resistant; reverse genetics; surgery",Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects,,75035,HM,Hypertension and Microcirculation Study Section,S1,4,165589,
8004293,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK075058-03S1,,NIDDK:88765;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AMHERST,UNITED STATES,NONE,01,153926712,US,MA,010039242,UNIVERSITY OF MASSACHUSETTS AMHERST,"SCHNEYER, ALAN L;",1862034;,3R01DK075058,01/15/2010,03/31/2010,"0-11 years old; 21+ years old; Activin-Binding Protein; Activins; Adult; Affect; Affinity; Anabolism; Autoregulation; B9 endocrine pancreas; BMP15; BMP15 gene; Binding; Binding (Molecular Function); Bioavailability; Biochemical; Biologic Availability; Biological; Biological Availability; Birth; Body Tissues; Bone Morphogenetic Proteins; Cancers; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Characteristics; Child; Child Youth; Children (0-21); Compensation; Data; Defect; Development; Diabetes Mellitus; Diagnosis; Difficulty conceiving; Disease; Disorder; Drug or chemical Tissue Distribution; Drugs; Estrus; FLR; FSH-Releasing Protein; Failure (biologic function); Family member; Fats; Fatty acid glycerol esters; Fertility/Fertilization; Fertilization; Financial compensation; Follistatin; GDF9B Gene; GFAC; Gametogenesis; Gastrointestinal Tract, Pancreas; Generalized Growth; Genes; Goals; Growth; Growth Agents; Growth Differentiation Factor 9B Gene; Growth Factor; Growth Factors, Proteins; Growth Substances; Hepatic; Homeostasis; Hour; Human; Human, Adult; Human, Child; Human, General; Humulin R; Hyperplasia; Hyperplastic; Hypophysis; Hypophysis Cerebri; IRS2; IRS2 protein, human; In Vitro; Individual; Infertility; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor Substrate 2; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Isoforms; Knock-in; Knock-in Mouse; Lead; Litter Size; METBL; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Messenger RNA; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Mutant Strains; Modeling; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Nervous System, Pituitary; Nesidioblasts; Novolin R; Obesity; Oocytes; Ovarian; Ovarian Failure, Premature; Ovocytes; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Parturition; Pathway interactions; Pattern; Pb element; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiologic; Physiologic Availability; Physiological; Physiological Homeostasis; Physiology; Pituitary; Pituitary Gland; Premature Ovarian Failure; Principal Investigator; Protein Cleavage; Protein Isoforms; Proteolysis; RNA Splicing; RNA, Messenger; Regulation; Reproduction; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Testing; Tissue Distribution; Tissue Growth; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Visceral; adiposity; adult human (21+); beta cell development; bioavailability of drug; biological signal transduction; biosynthesis; children; corpulence; corpulency; corpulentia; diabetes; diabetes mellitus therapy; diabetes therapy; disease/disorder; drug/agent; endocrine pancreas; endocrine pancreas development; estrous; failure; folliculogenesis; glucose tolerance; heavy metal Pb; heavy metal lead; hepatic gluconeogenesis; human IRS2 protein; in vivo; infertile; insulin resistant; insulin sensitivity; intraovarian; islet; islet development; islet progenitor; mRNA; malignancy; mouse model; mouse mutant; myostatin; neonatal death; neoplasm/cancer; novel; obese; obese people; obese person; obese population; ontogeny; pathway; premature; prototype; reproductive; response; social role; type I and type II diabetes; unable to bear children; youngster",Physiologic Roles of Activin and Myostatin Antagonists,,75058,ZRG1,Special Emphasis Panel,S1,3,88765,
8010069,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK075607-04S2,,NIDDK:44897;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SALT LAKE CITY,UNITED STATES,GENETICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"THUMMEL, CARL S.;",1933531;,3R01DK075607,01/15/2010,03/31/2010,"2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; 20-Hydroxyecdysone; 21+ years old; 9-cis-Retinoic Acid Receptor; Active Follow-up; Address; Adolescent; Adolescent Youth; Adult; Animals; Antibodies; Autoregulation; Beta-Ecdysone; Biological; Biological Metamorphosis; Biological Models; C elegans; C.elegans; Caenorhabditis elegans; Cardiovascular Diseases; Characteristics; Chemotherapy-Hormones/Steroids; Cholest-5-en-3-ol (3beta)-; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2beta,3beta,5beta,22R)-; Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-, (2beta,3beta,5beta,22R)-; Cholesterol; Cicloheximide; Collection; Commit; Complex; Crustecdysone; Cycloheximide; Data; Development; Diabetes Mellitus; Drosophila; Drosophila genus; Drosophila melanogaster; Dysfunction; Ecdysone; Ecdysterone; Endocrine Gland Secretion; Flies; Fruit Fly, Drosophila; Functional disorder; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Transcription; Genomics; Growth; Homeostasis; Hormones; Human; Human, Adult; Human, General; Intermediary Metabolism; Investigators; Lipids; METBL; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Metamorphosis, Biological; Model System; Modeling; Models, Biologic; Molecular; Molting Hormone; Nuclear Receptor Gene; Nuclear Receptors; Obesity; Ortholog; Orthologous Gene; Pathway interactions; Pattern; Phase; Physiologic pulse; Physiological Homeostasis; Physiopathology; Programs (PT); Programs [Publication Type]; Pulse; RNA Expression; RXR; RXR Protein; Receptor Protein; Receptor Signaling; Receptors, Steroid; Regulation; Research Personnel; Researchers; Retinoic Acid Receptor RXR; Retinoid X Receptors; Role; SXR; SXR receptor; Signal Pathway; Staging; Steroid Compound; Steroid Receptors; Steroids; Sterols; Targetings, Gene; Testing; Therapeutic Hormone; Therapeutic Steroid Hormone; Tissue Growth; Transcription; Transcription, Genetic; Vertebrate Animals; Vertebrates; adiposity; adult human (21+); cardiovascular disorder; corpulence; corpulency; corpulentia; diabetes; ecdysteroid receptor; ecdysterone receptor; fat metabolism; fly; follow-up; fruit fly; gain of function; gain of function mutation; human disease; in vivo; juvenile; juvenile human; lipid metabolism; loss of function; member; metamorphosis; mutant; obese; obese people; obese person; obese population; ontogeny; pathophysiology; pathway; programs; receptor; receptor, 20-hydroxyecdysone; reproductive; response; social role; steroid X receptor; steroid and xenobiotic receptor; steroid hormone; steroid hormone receptor; steroid metabolism; tool; vertebrata",Regulation and Function of Drosophila Nuclear Receptors,,75607,MCE,Molecular and Cellular Endocrinology Study Section,S2,4,44897,
8012965,R01,DK,3,Y,01/28/2010,04/27/2010,PA-07-070,3R01DK075801-03S1,,NIDDK:10400;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DAVIS,UNITED STATES,BIOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"BODINE, SUE C;FURLOW, J DAVID (contact);",1923416 (contact);8029146;,3R01DK075801,01/28/2010,04/27/2010,"ADRGND; Adrenal Glands; Adrenals; Adrenergic Agonists; Adrenergic Receptor Agonist; Adrenomimetics; Adverse effects; Aging; Animal Welfare; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Assay; Atrophic; Atrophy; Atrophy, Muscle; Base Pairing; Benzenemethanol, 4-amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)-; Bibliography; Bioassay; Biologic Assays; Biological Assay; Bone; Bone and Bones; Bones and Bone Tissue; CHIP assay; Cachexia; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Cells; ChIP (chromatin immunoprecipitation); Chemotherapy-Hormones/Steroids; Chronic Disease; Chronic Illness; Clenbuterol; Country; Data; Drugs; E3 Ligase; E3 Ubiquitin Ligase; Ecological impact; Electroporation; Endocrine Gland Secretion; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fasting; Fluorescence; Funding; Gene Deletion; Gene Expression; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glucocorticoid Receptor; Glucocorticoids; Grant; Health; Hormones; Human; Human, General; Hyperglycemia; IACUC; IGF-1; IGF-I; IGF-I-SmC; IGF1; IRBs; Immobilization; Impact, Environmental; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; International; Intracellular Communication and Signaling; Investigators; Laboratories; Life; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Murine; Mus; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Mutation; Nature; Nerve; Nervous; Paper; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; Regulatory Element; RegulatoryElement; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiratory physiology; Role; Senescence; Sepsis; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Somatomedin C; Study Section; Techniques; Therapeutic Glucocorticoid; Therapeutic Hormone; Transcription Activation; Transcriptional Activation; Transfection; Treatment Side Effects; Ubiquitin-Protein Ligase E3; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Work; abstracting; biological signal transduction; bloodstream infection; bone; chromatin immunoprecipitation; chronic disease/disorder; chronic disorder; clinical relevance; clinically relevant; drug/agent; experiment; experimental research; experimental study; expiration; expression vector; fasted; fasts; gene deletion mutation; gene induction; gene product; genetic resource; genome mutation; human subject; hyperglycemic; immobilization of body part; insulin resistant; interest; lung function; material transfer agreement; muscle form; orthopedic freezing; programs; research study; respiratory function; response; senescent; side effect; skeletal muscle wasting; social role; success; suprarenal gland; therapy adverse effect; tool; treatment adverse effect; ubiquitin-protein ligase; vertebrata",Glucocorticoid control of gene expression during skeletal muscle atrophy,,75801,SMEP,Skeletal Muscle and Exercise Physiology Study Section,S1,3,10400,
8008942,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK075897-03S1,,NIDDK:62037;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"YEE, VIVIEN ;",6104486;,3R01DK075897,01/15/2010,03/31/2010,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 1H-thieno(3,4-d)imidazole-4-pentanoic acid, 1-carboxyhexahydro-2-oxo-, (3aS-(3a alpha,4 beta,6a alpha))-; Acidity; Active Sites; Address; Affect; Amino Acid Substitution; Amino Acids; Animal Welfare; Bacteria; Bibliography; Binding; Binding (Molecular Function); Biochemical; Biological Models; Biotin; CO2; Carbon Dioxide; Carbonic Anhydride; Carboxyl Transferases; Carboxyltransferases; Catabolism; Catalysis; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Co element; Cobalt; Coenzyme A, S-(2-methyl-2-butenoate), (E)-; Complex; Country; Critiques; Crystallization; Data; Decarboxylation; Dependence; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Enzymes; Equipment; Ethics Committees, Research; Fatty Acids; Genes; Genetic Alteration; Genetic Change; Genetic defect; Gluconeogenesis; H+ element; Human; Human, General; Hydrogen Ions; IACUC; IRBs; Image; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Ions; Ketosuccinates; Label; Lead; Ligand Binding; Ligands; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Methods; Methods and Techniques; Methods, Other; Methylmalonyl-CoA carboxyltransferase; Methylmalonyl-CoA carboxytransferase; Missense Mutation; Model System; Models, Biologic; Molecular Interaction; Monitor; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Mutation, Missense; N1'-carboxybiotin; Nature; Outcome; Oxaloacetates; Oxosuccinates; Patients; Pb element; Play; Population; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Propionic Acids; Propionyl-CoA Carboxylase; Propionyl-Coenzyme A Carboxylase; Proteins; Protons; Publishing; Pyruvate; Pyruvates; Raman Spectroscopy; Raman Spectrum Analysis; Raman spectrometry; Reaction; Relative; Relative (related person); Research; Research Design; Research Ethics Committees; Research Resources; Resolution; Resources; Role; Sampling; Shapes; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Spectroscopy; Spectroscopy, IR/UV/Raman; Spectrum Analyses; Spectrum Analysis; Spectrum Analysis, Raman; Staining method; Stainings; Stains; Stretching; Structure; Study Type; Targeted DNA Modification; Targeted Modification; Techniques; Testing; Thesaurismosis; Vertebrate Animals; Vertebrates; Vitamin H; Yeasts; abstracting; aminoacid; biotin 2; carbon dioxide transport; carboxybiotin; carboxylation; coenzyme R; cofactor; deprotonation; design; designing; developmental disease/disorder; developmental disorder; disease/disorder; enolate; enzyme complex; enzyme deficiency; experiment; experimental research; experimental study; expiration; gene product; genome mutation; glucose biosynthesis; heavy metal Pb; heavy metal lead; human subject; imaging; inhibitor; inhibitor/antagonist; ketotic glycinemia; ketotic hyperglycinemia; lactic acidemia; metabolism disorder; methylcrotonyl-CoA; methylmalonyl-CoA decarboxylase; methylmalonyl-coenzyme A carboxyltransferase; novel; oxidation; particle; programs; propionic acidemia; propionyl coA carboxylase deficiency; propionyl-CoA; propionyl-coenzyme A; protein folding; research study; response; social role; structural biology; study design; tiglyl-CoA; tiglyl-coenzyme A; tool; transcarboxylase; vertebrata",Structural biology of biotin-dependent carboxylases,,75897,ZRG1,Special Emphasis Panel,S1,3,62037,
7998875,R01,DK,3,Y,01/15/2010,03/31/2010,,3R01DK076027-03S1,,NIDDK:4500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"O'BRIEN, RICHARD M;",2085437;,3R01DK076027,01/15/2010,03/31/2010,"21+ years old; ATP[{..}]D-glucose 6-phosphotransferase; Abscission; Address; Adenoviridae; Adenoviruses; Adult; Amino Acids; Animals; Applications Grants; Autoantigens; Autoimmune Responses; Autologous Antigens; B9 endocrine pancreas; Beta Cell; Biological; Blood Glucose; Blood Sugar; Breeding; CD8; CD8B; CD8B1; CD8B1 gene; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Childhood; Cloning; Collaborations; Complementary DNA; D-Glucose; D-Glucose-6-phosphate phosphohydrolase; DNA, Complementary; Data; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Epitopes, T-Lymphocyte; Excision; Extirpation; Fasting; Gastrointestinal Tract, Pancreas; Gene Deletion; Gene Expression; Gene Products, RNA; Generations; Genes; Glucokinase; Glucose; Glucose-6-Phosphate; Glucose-6-Phosphate Phosphohydrolase; Goals; Grant Proposals; Grants, Applications; Hour; Human, Adult; Humulin R; Hydrolysis; Hyperglycemia; Hypoglycemia; IDD; IDDM; Immune system; Immunology; Immunology (Including BRMP); Immunology (NCI Program); In Situ; In Vitro; Inbred NOD Mice; Incidence; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intermediary Metabolism; Investigators; Islands of Langerhans; Islet Cells; Islets of Langerhans; Job Environment; Job Location; Job Place; Job Setting; Job Site; Kidney; Knock-out; Knockout; Knockout Mice; LYT3; Laboratories; Lead; Length; Literature; Liver; METBL; Mammals, Mice; Metabolic Processes; Metabolism; Mice; Mice, Inbred NOD; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Mother Cells; Mouse, NOD; Murine; Mus; Names; Nesidioblasts; Non obese; Non-Obese Diabetic Mice; Nonobese; Nonobese Diabetic Mouse; Novolin R; Null Mouse; OGTT; Oral Glucose Tolerance; Oral Glucose Tolerance Test; Outcome; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Paper; Pars endocrina pancreatis; Pathogenesis; Pathway interactions; Pb element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Phosphates; Physiologic; Physiological; Predisposition; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Publishing; RNA; RNA Splicing; RNA, Non-Polyadenylated; Removal; Research; Research Personnel; Researchers; Reticuloendothelial System, Thymus; Ribonucleic Acid; Role; Self-Antigens; Splicing; Stem cells; Subcellular Process; Surgical Removal; Susceptibility; T-Cell Epitopes; T-Cells; T-Lymphocyte; T-Lymphocyte Epitopes; T1 diabetes; T1D; T1DM; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Type 1 diabetes; Universities; Urinary System, Kidney; Work Location; Work Place; Work-Site; Workplace; Worksite; adult human (21+); aminoacid; autoreactivity; base; beta cell development; body system, allergic/immunologic; body system, hepatic; cDNA; cost; cultured cell line; cytotoxic; diabetes; diabetic; diabetic patient; disease/disorder; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; fasted; fasts; gene deletion mutation; gene product; glucose sensor; glucose-6-phosphatase; heavy metal Pb; heavy metal lead; hyperglycemic; hypoglycemic; hypoglycemic episodes; in vivo; inorganic phosphate; insulin dependent diabetes; insulin dependent diabetes mellitus onset; insulin secretion; interest; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; mouse model; novel; organ system, allergic/immunologic; organ system, hepatic; overexpression; pathway; pediatric; prevent; preventing; programs; renal; research study; resection; shRNA; short hairpin RNA; small hairpin RNA; social role; thymus derived lymphocyte; type I diabetes; work environment; work setting",The Role of IGRP in the Pathogenesis of Type 1 Diabetes,,76027,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,3,4500,
8004347,R01,DK,3,Y,01/11/2010,12/31/2010,,3R01DK076050-03S1,,NIDDK:101364;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAPEL HILL,UNITED STATES,NUTRITION,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"POMP, DANIEL ;",1977201;,3R01DK076050,01/11/2010,12/31/2010,"Accounting; Address; Alleles; Allelomorphs; Ammon Horn; Animal Model; Animal Models and Related Studies; Apoplexy; Architecture; Bayesian Method; Body Composition; Body Tissues; Body Weight; Body Weight decreased; Body fat; Breeding; Caloric Intake; Cancers; Candidate Disease Gene; Candidate Gene; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cis-Trans Tests; Complex; Cornu Ammonis; DNA Recombination; DNA recombination (naturally occurring); Data; Data Set; Dataset; Economics; Energy Intake; Engineering / Architecture; Environment; Exercise; Exercise, Physical; Expenditure; Gastrocnemius muscle structure; Gene Expression; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Recombination; Genetic Susceptibility; Genetic Variation; Genome; Genotype; Goals; HDL; Health; Health Expenditures; Heart Diseases; Heavy Lipoproteins; High Density Lipoproteins; High density lipoprotein; Hippocampus; Hippocampus (Brain); Human; Human, General; Individual; Inherited Predisposition; Inherited Susceptibility; Investigation; Knowledge; LDL triglyceride; Lipoproteins, HDL; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maps; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Messenger RNA; Metabolic; Method, Bayesian; Methods; Mice; Modeling; Murine; Mus; Muscle, Gastrocnemius; Myocardial Infarct; Myocardial Infarction; NMR Imaging; NMR Tomography; Nature; Nuclear Magnetic Resonance Imaging; Obesity; Obesity associated disease; Obesity related disease; Outcome; Pathway interactions; Phenotype; Physical activity; Physiologic; Physiological; Physiology; Play; Polygenic Characters; Polygenic Inheritances; Polygenic Traits; Population; Position; Positioning Attribute; Predisposition; Predisposition gene; Preventive; Principal Investigator; QTL; Quantitative Trait Loci; RNA, Messenger; Recombination; Recombination, Genetic; Reporting; Research; Research Resources; Resources; Rodent; Rodentia; Rodentias; Role; Running; Stroke; Susceptibility; Susceptibility Gene; Testing; Tissues; Variant; Variation; Variation (Genetics); Vascular Accident, Brain; Weight; Weight Loss; Weight Reduction; Zeugmatography; adiposity; allelic variant; alpha-Lipoproteins; base; body weight loss; brain attack; caloric dietary content; cardiac infarct; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; energy balance; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome, mouse; genome-wide; health care expenditure; heart attack; heart disorder; heart infarct; heart infarction; hippocampal; human disease; innovate; innovation; innovative; insulin sensitivity; lipoprotein, LDL triglyceride; low density lipoprotein triglyceride; mRNA; malignancy; meetings; model organism; molecular phenotype; mouse genome; mouse model; neoplasm/cancer; new approaches; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; pathway; predisposing gene; prevent; preventing; social; social role; stroke; tool; trait; triacylglycerol LDL; wt-loss",Genetic Architecture of Voluntary Exercise in Mice,,76050,GVE,Genetic Variation and Evolution Study Section,S1,3,101364,
8000907,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK076118-02S1,,NIDDK:24910;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WORCESTER,UNITED STATES,GENETICS,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"WANG, YONG-XU ;",8442943;,3R01DK076118,01/15/2010,03/31/2010,"Adipocytes; Adipose Cell; Adipose Tissue, Brown; Adipose tissue; Adrenergic Receptor; Adrenoceptors; Agonist; Assay; Bioassay; Biochemical; Biogenesis; Biologic Assays; Biological Assay; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Brown Fat; Burn injury; Burns; C-terminal; CHIP assay; Cell Nucleus; Cell Respiration; Cell surface; Cellular Respiration; ChIP (chromatin immunoprecipitation); Dependency; Dependency (Psychology); Diet; Electron Transport; Energy Expenditure; Energy Metabolism; Event; Exhibits; Expenditure; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Gene Targeting; Gene Transcription; Genes; Genetic; Genetic Transcription; Glucose Intolerance; Goals; Heat Production; Hibernating Gland; Insulin Resistance; Intermediary Metabolism; Knockout Mice; Link; Lipocytes; METBL; Mature Lipocyte; Mature fat cell; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Molecular; Nuclear Receptors; Nucleus; Null Mouse; Obesity; Origin of Life; PPAR; PPAR delta; PPARD protein; PPARdelta; Pathway interactions; Peroxisome Proliferator-Activated Receptor delta; Peroxisome Proliferator-Activated Receptors; Physiologic; Physiological; Play; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; Receptor Signaling; Receptors, Epinephrine; Regulation; Reporter; Research; Resistance; Role; Site; Targetings, Gene; Testing; Therapeutic; Thermogenesis; Thesaurismosis; Tissues; Transcription; Transcription, Genetic; Transgenic Mice; Wild Type Mouse; Work; adenoreceptor; adipogenesis; adipose; adiposity; aerobic metabolism; aerobic respiration; base; bone; cell type; chromatin immunoprecipitation; corpulence; corpulency; corpulentia; electron transfer; emotional dependency; fat metabolism; fatty acid oxidation; gain of function; gene product; in vivo; insulin resistant; lipid biosynthesis; lipid metabolism; lipogenesis; metabolism disorder; mitochondrial; obese; obese people; obese person; obese population; overexpression; oxidative metabolism; pathway; prevent; preventing; programs; resistant; social role; transcription factor; white adipose tissue; yellow adipose tissue",PPARdelta and its co-regulators in energy metabolism,,76118,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,2,24910,
8011152,R01,DK,3,Y,01/12/2010,01/11/2011,PA-04-101,3R01DK076602-05S1,,NIDDK:99783;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"SHEN, MICHAEL M.;",1868653;,3R01DK076602,01/12/2010,01/11/2011,"21+ years old; Adult; Age; Aging; Androgenic Agents; Androgenic Compounds; Androgens; Assay; Autoregulation; Bioassay; Biologic Assays; Biological; Biological Assay; Body Tissues; Cancer stem cell; Cancers; Castration; Cell Culture Techniques; Cell Function; Cell Growth and Maintenance; Cell Maintenance; Cell Process; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Cytofluorometry, Flow; DNA Recombination; DNA recombination (naturally occurring); Defect; Disease; Disorder; Epithelial; Epithelial Cells; Epithelium; Expression Profiling; Expression Signature; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Future; Genes, Homeo Box; Genes, Homeobox; Genetic; Genetic Recombination; Genital System, Male, Prostate; HOX gene; Homeobox Family Gene; Homeobox Genes; Homeodoamin Gene; Homeostasis; Homeotic Genes; Human Prostate; Human Prostate Gland; Human, Adult; Investigation; Investigators; Label; Link; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Mice, Mutant Strains; Microfluorometry, Flow; Molecular; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Murine; Mus; Mutant Strains Mice; Natural regeneration; Normal Tissue; Normal tissue morphology; Organ; Pathway interactions; Physiological Homeostasis; Population; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prostate; Prostate Disease; Prostate Gland; Prostatic Diseases; Prostatic Gland; Recombination; Recombination, Genetic; Regeneration; Regulation; Regulatory Pathway; Research Personnel; Researchers; Role; Senescence; Side; Stem cells; Subcellular Process; Surgical Castration; System; System, LOINC Axis 4; Therapeutic; Therapeutic Androgen; Tissue Recombination; Tissues; Wound Healing; Wound Repair; adult human (21+); adult stem cell; base; cell type; deprivation; disease/disorder; flow cytophotometry; in vivo; insight; interest; male; malignancy; molecuar profile; molecular signature; mouse mutant; neoplasm/cancer; novel; pathway; progenitor; programs; prostate carcinogenesis; prostate disorder; public health relevance; regenerate; regenerate new tissue; regenerating damaged tissue; response; self-renewal; senescent; social role; tissue regeneration; tissue repair",Progenitor cells of the mouse prostate epithelium,,76602,ZRG1,Special Emphasis Panel,S1,5,99783,
8007473,R01,DK,3,Y,01/01/2010,04/30/2010,,3R01DK076937-04S1,,NIDDK:10000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"VEVES, ARISTIDIS ;",3154211;,3R01DK076937,01/01/2010,04/30/2010,"Active Follow-up; Amputation; Area; Biochemical Markers; Blood Vessels; Blood flow; Body Tissues; Cardiovascular Diseases; Charcot foot; Clinical; Development; Diabetes Mellitus; Diabetic Foot; Diabetic Foot Ulcer; Dysfunction; Enrollment; FLR; Failure (biologic function); Foot; Foot Ulcer, Diabetic; Functional disorder; HOSP; Healed; Healing abnormal; Healing delayed; Hospitalization; INFLM; Image; Impaired healing; Impaired tissue repair; Impaired wound healing; Inflammation; Investigators; Knowledge; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Markers, Biochemical; Measurement; Medical; Medical Imaging; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods and Techniques; Methods, Other; Microcirculation; Mother Cells; Muscle; Muscle Tissue; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; O element; O2 element; Oxygen; PNS Diseases; Patients; Peripheral Nerve Diseases; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Pes; Physiopathology; Population; Progenitor Cells; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Research Personnel; Researchers; Risk; Skin; Stem cells; Techniques; Tissues; ULCN; Ulcer; Ulceration; Work; Wound Healing; Wound Repair; Zeugmatography; abnormal tissue repair; cardiovascular disorder; delayed wound healing; diabetes; diabetic patient; enroll; failure; follow-up; foot; healing; imaging; muscle metabolism; new therapeutics; next generation therapeutics; novel therapeutics; pathophysiology; prognostic; programs; response; tissue oxygen saturation; tissue oxygenation; tissue repair; vascular; wound",Impaired Wound Healing in Diabetic Foot Ulceration,,76937,MRS,Musculoskeletal Rehabilitation Sciences Study Section,S1,4,10000,
8007206,R01,DK,3,Y,01/20/2010,04/03/2010,PA-07-070,3R01DK077050-01A2S2,,NIDDK:71491;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"STUENKEL, EDWARD L;",1884912;,3R01DK077050,01/20/2010,04/03/2010,"Affect; B9 endocrine pancreas; Binding; Binding (Molecular Function); Biochemical; Body Tissues; Capacitance, Electrical; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Competence; Complex; Coupled; Coupling; Cytoplasmic Granules; D-Glucose; Data; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Docking; Dysfunction; Electric Capacitance; Endocrine Gland Secretion; Event; Exocytosis; FRET; Family; Fluorescence Resonance Energy Transfer; Functional disorder; GTP; GTP Binding; GTP Phosphohydrolases; GTPases; Gastrointestinal Tract, Pancreas; Glucose; Goals; Growth and Development; Growth and Development function; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hormones; Humulin R; Hydrolysis; Inbred C3H Mice; Individual; Infection; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Kinetic; Kinetics; Life; Link; Location; MODY; Maintenance; Maintenances; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Membrane; Membrane Fusion; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Mice, Inbred C3H; Molecular; Molecular Interaction; Monitor; Mouse, C3H; Murine; Mus; NIDDM; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nucleotides; Optics; Organelles; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Physiopathology; Population; Property; Property, LOINC Axis 2; Proteins; Rab27a protein; Regulation; Reporting; Research; Resistance; Role; SUBGP; Secretory Granules; Secretory Vesicles; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Staging; Stimulus; Subcellular Process; Subgroup; T2D; T2DM; Techniques; Therapeutic; Therapeutic Hormone; Therapeutic Intervention; Time; Tissues; Type 2 diabetes; Type II diabetes; Work; adult onset diabetes; beta cell development; biological signal transduction; blood glucose regulation; capacitance; diabetes; diabetic patient; disease/disorder; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; fat metabolism; gene product; glucose control; glucose homeostasis; glucose regulation; granule; guanosinetriphosphatase; insulin secretion; intervention therapy; islet development; islet progenitor; ketosis resistant diabetes; lipid metabolism; maturity onset diabetes; membrane structure; mouse model; patch clamp; pathophysiology; pathway; public health relevance; rab 27a protein; research study; resistant; response; social role",Mechanisms of Rab27 regulation of insulin secretion," Narrative Insulin secreted by ¨-cells of pancreatic islets is essential for maintenance of glucose homeostasis as well as for tissue development and growth. Type-2 diabetes, a disease predicted to affect 250 million people worldwide by the year 2020, occurs when the ability of the ¨-cells to release insulin is exceeded by the requirements for the hormone to regulate glucose and lipid metabolism. In diabetic patients, early manifestations of ¨-cell dysfunction include delayed and blunted insulin secretory responses to glucose challenges and loss of tight stimulus-secretion coupling. Therefore, there is a critical necessity to understand in full molecular and mechanistic detail the secretory pathway underlying insulin secretion to ultimately develop therapeutic treatments for diabetes.",77050,CADO,Cellular Aspects of Diabetes and Obesity Study Section,A2S2,1,71491,
8010020,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK077086-03S1,,NIDDK:32000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,ANATOMY/CELL BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LIN, JIANDIE D;",7575494;,3R01DK077086,02/01/2010,04/30/2010,"Apolipoproteins; Autoregulation; Biochemical; Biological; Blood Glucose; Blood Plasma; Blood Sugar; Cell Communication and Signaling; Cell Signaling; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Communicating Junction; Data; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dyslipidemias; Epidemic; Fats; Fatty Acids; Fatty acid glycerol esters; Gap Junctions; Gene Expression; Goals; Hepatic; Homeostasis; Hormonal; Hyperglycemia; Hyperglyceridemia; Hyperlipemia; Hyperlipidemia; Hypertriglyceridemia; Insulin Resistance; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Link; Lipid Trafficking; Lipids; Lipoproteins; Liver; Low-resistance Junction; METBL; MODY; Maintenance; Maintenances; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolic syndrome; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Transgenic; Molecular; Murine; Mus; NIDDM; Nexus; Nexus Junction; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nutritional; Obesity; Pathogenesis; Pathway interactions; Physiological Homeostasis; Plasma; Play; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Raised TG; Raised triglycerides; Recruitment Activity; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; Sequence-Specific Posttranscriptional Gene Silencing; Serum, Plasma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Syndrome; T2D; T2DM; Testing; Thesaurismosis; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenic Mice; Transgenic Organisms; Triacylglycerol; Triglyceride increased; Triglycerides; Triglycerides high; Type 2 diabetes; Type II diabetes; adenoviral-mediated; adipogenesis; adiposity; adult onset diabetes; base; biological signal transduction; blood glucose regulation; body system, hepatic; cardiovascular disease risk; cardiovascular disorder risk; chromatin remodeling; corpulence; corpulency; corpulentia; disease/disorder; elevated tg; elevated triglyceride; fat metabolism; genome-wide; glucose control; glucose homeostasis; glucose regulation; hyperglycemic; insight; insulin resistant; insulin sensitivity; ketosis resistant diabetes; lipid biosynthesis; lipid metabolism; lipid transport; lipogenesis; lipoprotein triglyceride; maturity onset diabetes; metabolism disorder; novel; obese; obese people; obese person; obese population; organ system, hepatic; pathway; programs; recruit; saturated fat; social role; transcription factor; transgenic",PGC-1beta in the Regulation of Hepatic Lipid Metabolism,,77086,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,3,32000,
8007021,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK077816-01A2S1,,NIDDK:60000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LINCOLN,UNITED STATES,MISCELLANEOUS,01,555456995,US,NE,685880430,UNIVERSITY OF NEBRASKA LINCOLN,"ZEMPLENI, JANOS ;",6187589;,3R01DK077816,01/07/2010,12/31/2010,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 3-methylcrotonyl CoA carboxylase; Aberrant Chromosome; Abnormalities, Chromosomal; Acetyl Coenzyme A Carboxylase; Acetyl-CoA Carboxylase; Acetyl-CoA[{..}]carbon-dioxide ligase (ADP-forming); Address; Affect; Affinity; American; Amides; Assay; Autoregulation; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biotin; Biotinylation; CHIP assay; Cancers; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell surface; CellLine; Cells; Cellular Proliferation; ChIP (chromatin immunoprecipitation); Chaperone; Chromatin; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Co-Immunoprecipitations; Coenzymes; Cofactors, Enzyme; Computer Simulation; Computerized Models; Culture Media; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytoplasm; DNA Binding Domain; DNA Damage Repair; DNA Repair; DNA-Binding Proteins; Dietary intake; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Gene Action Regulation; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, Reporter; Genetic Transcription; Genome Stability; Genomics; Goals; Health; Heterochromatin; Histone H2A; Histone H3; Histone H4; Histones; Holocarboxylase Synthetase Deficiency; Homeostasis; Human; Human Cell Line; Human, General; K-18; K-18 conjugate; K12; K18; K18 combination; L-Lysine; Ligand Binding Protein; Ligase; Link; Lymphoid Cell; Lysine; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Models, Computer; Molecular Chaperones; Molecular Interaction; Multiple Carboxylase Deficiency, Neonatal Form; Multivitamin; Na element; Nuclear; Nuclear Translocation; Nucleus; Nutrient; Overdose; Physiological Homeostasis; Play; Pregnant Women; Process; Propionyl-CoA Carboxylase; Propionyl-Coenzyme A Carboxylase; Protein Motifs, DNA-Binding; Proteins; Public Health; Pyruvate Carboxylase; Pyruvate[{..}]carbon-dioxide ligase (ADP-forming); RNA Expression; RNA, Messenger; Recruitment Activity; Regulation; Relative; Relative (related person); Reporter Genes; Repression; Retrotransposon; Risk; Role; SECTM1; SECTM1 gene; Simulation, Computer based; Site; Sodium; Stability, Genomic; Structure; Supplementation; Synthetases; Techniques; Testing; Time; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Transgenic Organisms; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Unscheduled DNA Synthesis; Vitamin H; Vitamins; Yeasts; beta-methylcrotonyl-CoA carboxylase; biotin holocarboxylase synthetase; biotin symporter; biotin transporter; cancer risk; chromatin immunoprecipitation; chromatin remodeling; coenzyme R; coenzyme analog; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cultured cell line; experiment; experimental research; experimental study; gene product; gene repression; growth media; holocarboxylase synthetases; holoenzyme synthetase; in silico; mRNA; malignancy; meetings; methylcrotonoyl-CoA carboxylase; methylcrotonyl coA carboxylase; methylcrotonyl-coenzyme A carboxylase; methylmalonyl-CoA decarboxylase; neoplasm/cancer; public health medicine (field); public health relevance; pyruvic carboxylase; recruit; research study; response; sensor; social role; transgenic; uptake; virtual simulation",Biotin sensing and chromatin remodeling by holocarboxylase synthetase," Relevance to public health: Biotinylation of histones is a unique epigenetic mark because it depends on the dietary intake of the essential vitamin biotin. Biotin deficiency is prevalent among Americans, and moderate biotin deficiency has been observed in up to 50% of pregnant women. Previous studies suggest that biotinylation of histones plays a critical role in gene regulation and genomic stability, thereby decreasing the risk for chromosomal abnormalities and cancer.",77816,INMP,Integrative Nutrition and Metabolic Processes Study Section,A2S1,1,60000,
8009199,R01,DK,3,Y,02/01/2010,04/30/2010,,3R01DK078090-03S1,,NIDDK:50930;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"HOLLENBERG, ANTHONY N;",1870785;,3R01DK078090,02/01/2010,04/30/2010,"5-Oxo-L-prolyl-L-histidyl-L-prolinamide; Adaptation, Physiological; Adaptations, Physiologic; Address; Autoregulation; Binding; Binding (Molecular Function); Binding Site Domain; Biological Models; Body Tissues; Cell Communication and Signaling; Cell Signaling; Complex; DNA Binding; DNA Binding Interaction; Development; Disease; Disorder; Enzymes; Fasting; Feedback; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genetic Models; Genetic Transcription; Genomics; Head and Neck, Thyroid; Histone Acetylation; Histone Deacetylation; Histones; Homeostasis; Human; Human Development; Human, General; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; In Vitro; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Isoforms; Knock-out; Knockout; L-Triiodothyronine; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-; Leptin; Ligand Binding Domain; Ligands; Light; Liothyronine; METBL; Macromolecular Protein Complexes; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Metabolic Processes; Metabolism; Methylation; Mice, Transgenic; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular; Molecular Interaction; Multiprotein Complexes; Nerve Cells; Nerve Unit; Nervous System, Pituitary; Neural Cell; Neurocyte; Neurons; Normal Range; Normal Values; Nucleic Acid Regulatory Sequences; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathway interactions; Photoradiation; Physiologic; Physiological; Physiological Adaptation; Physiological Homeostasis; Pituitary; Pituitary Gland; Play; Protein Isoforms; Protein Methylation; Protirelin; Protyreline; Pyr-His-ProNH2; RNA Expression; Receptor Protein; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Recruitment Activity; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Repression; Research Personnel; Researchers; Response Elements; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure of paraventricular nucleus; System; System, LOINC Axis 4; T-3; T3 Thyroid Hormone; TRH; Targetings, Gene; Testing; Therapeutic T3; Therapeutic Triiodothyronine; Thyreotropin; Thyroid; Thyroid Gland; Thyroid Gland Hormone; Thyroid Hormone Receptor; Thyroid Hormones; Thyroid Stimulating Hormone; Thyroid-Releasing Hormone; Thyroid-Stimulating Hormone; Thyrotropin; Thyrotropin-Releasing Hormone; Time; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transgenic Mice; Transgenic Organisms; Triiodothyronine; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; biological signal transduction; cofactor; disease/disorder; experiment; experimental research; experimental study; fasted; fasts; genetic regulatory element; hormone response element; hypothalamic; in vivo; in vivo Model; insight; mouse model; neuronal; novel; ob/ob mouse; paraventricular nucleus; pathway; receptor; recruit; research study; social role; transgenic",Negative regulation by thyroid hormone,,78090,MCE,Molecular and Cellular Endocrinology Study Section,S1,3,50930,
7992530,R01,DK,3,Y,02/01/2010,04/30/2011,,3R01DK078135-03S1,,NIDDK:70683;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,ANATOMY/CELL BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"FINGAR, DIANE C. CHRISTINE;",8663832;,3R01DK078135,02/01/2010,04/30/2011,"ATP-protein phosphotransferase; Actins; Amino Acids; Angioplasty; Anti-diabetic Agents; Antibodies; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Antidiabetic Agents; Antidiabetic Drugs; Assay; Autoregulation; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Birds of Prey; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular Stress; Clinical, Transplantation, Organ; Complex; Coronary Restenosis; Cultured Cells; Cytoskeletal System; Cytoskeleton; D-Glucose; Data; Development; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Drugs; Dysfunction; Exhibits; Functional disorder; GFAC; Gene Transcription; Genetic Transcription; Glucose; Goals; Graft Rejection; Grafting Procedure; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Homeostasis; Humulin R; Immunosuppressants; Immunosuppressive Agents; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; L-Serine; L-Threonine; Length of Life; Liquid Chromatography; Longevity; METBL; MODY; Malignant Neoplasms; Malignant Tumor; Maps; Mass Spectrum; Mass Spectrum Analysis; Maturity-Onset Diabetes Mellitus; Medication; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutrient; Obesity; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Pathway interactions; Peptide Biosynthesis, Ribosomal; Pharmaceutic Preparations; Pharmaceutical Preparations; Phospho-Specific Antibodies; Phosphopeptide-Specific Antibodies; Phosphopeptides; Phosphorylation; Phosphorylation Site; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase; Protein Phosphorylation; Protein Synthesis, Ribosomal; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; RAFT-1 gene product; RNA Expression; Rapamune; Rapamycin; Raptors; Regulation; Regulatory Protein; Role; Serine; Serine Kinase; Serine-Threonine Kinases; Serine/Threonine Phosphorylation; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Stimulus; Subcellular Process; T2D; T2DM; Techniques; Testing; Therapeutic; Threonine; Threonine Kinase; Threonine Phosphorylation Site; Transcription; Transcription, Genetic; Transplant Rejection; Transplantation Rejection; Transplantation Surgery; Type 2 diabetes; Type II diabetes; adiposity; adult onset diabetes; aminoacid; anti-diabetic drugs; antidiabetic; antitumor agent; biological signal transduction; cardiovascular disorder; cell growth; corpulence; corpulency; corpulentia; drug/agent; experiment; experimental research; experimental study; gene product; genetic regulatory protein; glycogen synthase a kinase; human disease; hydroxyalkyl protein kinase; immunosuppressive; in vivo; inhibitor; inhibitor/antagonist; intracellular skeleton; intraluminal angioplasty; ketosis resistant diabetes; life span; lifespan; mTOR gene product; mTOR protein; malignancy; mammalian target of rapamycin (mTOR); maturity onset diabetes; mimetics; mutant; neoplasm/cancer; novel; obese; obese people; obese person; obese population; organ allograft; organ graft; organ xenograft; pathophysiology; pathway; phosphorylase b kinase kinase; prevent; preventing; protein synthesis; regulatory gene product; research study; response; social role; tandem mass spectrometry; tumor","Identity, regulation, and function of mTOR phosphorylation sites",,78135,MCE,Molecular and Cellular Endocrinology Study Section,S1,3,70683,
8009558,R01,DK,3,Y,01/01/2010,12/31/2010,PA-06-254,3R01DK078158-03S1,,NIDDK:83611;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"SOUTHARD-SMITH, E MICHELLE;",1927876;,3R01DK078158,01/01/2010,12/31/2010,"Address; Alleles; Allelomorphs; Basic Research; Basic Science; Bladder; Bladder Diseases; Bladder Disorder; Bladder Disorder, Neurogenic; Bladder Dysfunction; Bladder, Neurogenic; Candidate Disease Gene; Candidate Gene; Causality; Cell Culture Techniques; Cell Lineage; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Migration; Childhood; DNA Recombination; DNA recombination (naturally occurring); Development; Developmental Defects, Neural Tube; Disease; Disorder; Dorsal; Engineering; Engineerings; Entire detrusor muscle of urinary bladder; Epithelium; Etiology; Exhibits; FLR; Failure (biologic function); Fetus; Future; Gene Transcription; Generalized Growth; Genes; Genetic Recombination; Genetic Transcription; Glia; Glial Cells; Goals; Grafting, Kidney; Growth; In Vitro; Individual; Investigators; Kidney; Kidney Failure; Kidney Insufficiency; Kidney Transplantation; Kidney Transplants; Knowledge; Kolliker's reticulum; Label; Lower urinary tract; Mammals, Mice; Maps; Mediating; Meningomyelocele; Meningomyelocoele; Methods; Mice; Mice, Transgenic; Modeling; Mother Cells; Motility; Motility, Cellular; Murine; Mus; Muscle; Muscle Development; Muscle Tissue; Muscle, Involuntary; Muscle, Smooth; Muscular Development; Myelomeningocele; Myofibroblast; NIH Program Announcements; Nerve Cells; Nerve Degeneration; Nerve Transmitter Substances; Nerve Unit; Nervous; Neural Cell; Neural Crest; Neural Tube Defects; Neural tube; Neurocyte; Neurogenic Bladder; Neuroglia; Neuroglial Cells; Neuron Degeneration; Neurons; Neuropathic Bladder; Neurotransmitters; Non-neuronal cell; Organ; Participant; Pathogenesis; Pathway interactions; Patients; Peripheral; Peripheral Nerves; Peripheral Nervous System; Pressure; Pressure- physical agent; Process; Progenitor Cells; Program Announcement; Programs (PT); Programs [Publication Type]; Proto-Oncogene, Signaling Factor; RNA Expression; Recombination; Recombination, Genetic; Renal Failure; Renal Insufficiency; Renal Transplantation; Renal Transplants; Reporting; Research Personnel; Researchers; Risk; Schistorrhachis; Secondary to; Sensory; Signal Pathway; Signaling Pathway Gene; Smooth muscle (tissue); Spina Bifida; Spinal Dysraphia; Spinal Dysraphias; Spinal Dysraphism; Spinal Dysraphisms; Staging; Stem cells; Strategic Planning; Technology; Testing; Time; Tissue Growth; Transcription; Transcription, Genetic; Transgenic Mice; Transgenic Organisms; Urinary Bladder Disorder, Neurogenic; Urinary Bladder Neurogenic Dysfunction; Urinary System, Bladder; Urinary System, Kidney; Urinary System, Urine; Urine; Urology; cell motility; cell type; cleft spine; detrusor muscle; developmental neurobiology; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; failure; fetal; high risk; hydrocele spinalis; immunoreactivity; innervation; insight; interest; knowledge base; melanocyte; migration; mouse model; nerve cement; nerve supply; neural; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; novel; ontogeny; pathway; pediatric; postnatal; pressure; progenitor; programs; rachischisis posterior; relating to nervous system; renal; stem cell population; transgene expression; transgenic; urinary bladder; urinary bladder disorder",Neural Crest Contributions to the Bladder,,78158,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,S1,3,83611,
8009212,R01,DK,3,Y,01/28/2010,04/27/2010,PA-07-301,3R01DK078184-03S1,,NIDDK:97941;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,MISCELLANEOUS,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"BURGESS, SHAWN C;",7615586;,3R01DK078184,01/28/2010,04/27/2010,"Animal Welfare; Autoregulation; Award; Bibliography; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Body Tissues; Carbohydrates; Citric Acid Cycle; Coagulation Factor I; Coagulation Factor One; Country; D-Glucose; Dextrose; Ecological impact; Environment; Environmental Impact; Enzymes; Equilibrium; Equipment; Ethics Committees, Research; Factor I; Factor One; Faculty; Fats; Fatty Acids; Fatty acid glycerol esters; Fibrinogen; Funding; Future; Genes; Gluconeogenesis; Glucose; Hepatic; Hepatic Mass; Homeostasis; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kidney; Krebs Cycle; Link; Lipids; Liver; Liver Mass; Mammals, Mice; Mammals, Rodents; Measurement; Measures; Metabolic; Metabolic Control; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Murine; Mus; Nuclear Magnetic Resonance; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); PEPCK; Pathway interactions; Phosphoenolpyruvate Carboxylase; Physiological Homeostasis; Preparation; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Pyruvate Carboxylase; Pyruvate[{..}]carbon-dioxide ligase (ADP-forming); RNA, Small Interfering; Research; Research Ethics Committees; Research Resources; Resources; Rodent; Rodentia; Rodentias; Small Interfering RNA; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TCA cycle; Techniques; Thesaurismosis; Time; Tissues; Tricarboxylic Acid Cycle; Urinary System, Kidney; Vertebrate Animals; Vertebrates; Work; abstracting; balance; balance function; body system, hepatic; expiration; fat metabolism; glucose RA; glucose biosynthesis; glucose production; glucose rate of appearance; human subject; interdisciplinary approach; interest; lipid metabolism; metabolism disorder; mouse model; organ system, hepatic; oxidation; pathway; phosphoenolpyruvate carboxykinase; programs; pyruvic carboxylase; renal; response; siRNA; surgery; vertebrata",Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer Analysis,,78184,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,3,97941,
8010067,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK078592-02S1,,NIDDK:17522;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,PHYSIOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"REPA, JOYCE J;",7732207;,3R01DK078592,01/15/2010,03/31/2010,"(1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone); 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; 9-cis-Retinoic Acid Receptor; ABC Transport Protein; ABC Transporter Protein; ABC Transporters; ATP-Binding Cassette Transporters; Absorption; Acids, Bile; Affect; Area; Assay; Autoprothrombin III; Back; Bile; Bile Acid Biosynthesis; Bile Acid Biosynthesis Pathway; Bile Acids; Bile Juice; Bile fluid; Biliary; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor X; Blood Serum; Carrier Proteins; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chemotherapy-Hormones/Steroids; Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Homeostasis; Cicloheximide; Coagulation Factor X; Computer Simulation; Computerized Models; Cycloheximide; DNA Molecular Biology; Data; Development; Dietary Fats; Dorsum; Drugs; Elements; Endocrine Gland Secretion; Enterocytes; Equilibrium; Excretory function; Exhibits; Factor X; Fenofibrate; Gallbladder Calculus; Gallbladder Stone; Gallstones; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Hepatic; Hormones; Human; Human, General; Hypercholesteremia; Individual Differences; Intestinal; Intestines; Knockout Mice; LDL Cholesterol; LDL Cholesterol Lipoproteins; Ligands; Liver; Low Density Lipoprotein Cholesterol; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Medication; Messenger RNA; Methods; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Models, Computer; Molecular; Molecular Biology; Molecular Mechanisms of Action; Murine; Mus; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nuclear Orphan Receptor; Null Mouse; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenofibrate; Physiology; Play; Process of absorption; Procetofen; Procetofene; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, 1-methylethyl ester; Proteins; Prower factor; RNA Expression; RNA, Messenger; RXR; RXR Protein; Receptor Protein; Regulation; Relative; Relative (related person); Reporter; Repression; Research; Retinoic Acid Receptor RXR; Retinoid X Receptors; Role; Serum; Simulation, Computer based; Sterols; Stuart Factor; Stuart-Prower Factor; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic; Therapeutic Hormone; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transport Proteins; Transporter Protein; Tricor; Work; absorption; balance; balance function; beta-Lipoprotein Cholesterol; bile acid anabolism; bile acid biosynthetic process; bile acid formation; bile acid synthesis; body system, hepatic; bowel; cholelith; cholesterol absorption; cholesterol metabolism; cholesterol trafficking; cholesterol transporters; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cultured cell line; dietary lipid; drug/agent; excretion; ezetimib; ezetimibe; gene product; hypercholesterolemia; in silico; inhibitor; inhibitor/antagonist; interest; mRNA; novel; organ system, hepatic; pathway; receptor; response; social role; tool; transcription factor; uptake; virtual simulation",Nuclear hormone receptor regulation of cholesterol absorption,,78592,INMP,Integrative Nutrition and Metabolic Processes Study Section,S1,2,17522,
8011777,R01,DK,3,Y,01/20/2010,01/19/2011,PA-07-070,3R01DK078655-02S1,,NIDDK:45727;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,PSYCHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"RANDICH, ALAN ;",1901683;,3R01DK078655,01/20/2010,01/19/2011,"21+ years old; 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-; Adolescent; Adolescent Youth; Adult; Agonist; Animal Testing; Bacterial Infections; Bladder; Bladder Diseases; Bladder Disorder; Bladder Tissue; Blood Pressure; Blotting, Western; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; CD71 Antigen; Cells; Common Rat Strains; Development; Disease; Disorder; Dorsal Horn Cells; ELISA; Electric Stimulation; Electrical Stimulation; Endo Brand of Naloxone Hydrochloride; Endogenous Opiates; Enzyme-Linked Immunosorbent Assay; Estrous Cycle; Exposure to; Female; Frequencies (time pattern); Frequency; Heating; Hour; Human, Adult; Hyperalgesia; Hyperalgesic Sensations; Hyperreflexia; INFLM; Ibotenic Acid; Incidence; Increased frequency of micturition; Individual; Inflammation; Inflammatory; Interstitial Cystitis; Intervention; Intervention Strategies; Knowledge; Lamepro Brand of Naloxone Hydrochloride; Lesion; Life; Life Experience; Mammals, Rats; Medulla Spinalis; Methodological Studies; Microinjections; Micturition Reflex; Modality; Modeling; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Naloxone; Narcan; Narcanti; Neonatal; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurons, Dorsal Horn; Neurons, Posterior Horn; Opiate Peptides; Opioid; Opioid Peptide; Opioid Receptor; Organism; Outcome; Pain; Painful; Peripheral; Population; Posterior Horn Cells; Process; Programs (PT); Programs [Publication Type]; Rat; Rattus; Receptor Protein; Receptors, Opiate; Reflex; Reflex action; Research; Spinal; Spinal Cord; Staging; Studies, Methodological; Symptoms; System; System, LOINC Axis 4; TFR1; TFRC protein, human; Tail; Testing; Transferrin Receptor 1; Transferrin Receptor Protein 1; Translations; United Drug Brand of Naloxone Hydrochloride; Urinary Frequency; Urinary System, Bladder; Urinary tract; Urination; Western Blotting; Western Blottings; Western Immunoblotting; Zymosan; adult human (21+); bacterial disease; base; disease/disorder; early experience; endogenous opioid; experience; extracellular; human TFRC protein; hyperalgia; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; living system; micturition; neonatal exposure; neural; neuronal; new therapeutics; next generation therapeutics; novel therapeutics; p90; painful bladder syndrome; programs; protein blotting; public health relevance; receptor; receptor expression; relating to nervous system; response; uRNA; urinary bladder; urinary bladder disorder; voiding; voiding reflex","Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain",,78655,SCS,Somatosensory and Chemosensory Systems Study Section,S1,2,45727,
8003137,R01,DK,3,Y,01/15/2010,06/30/2010,PA-07-070,3R01DK079233-02S1,,NIDDK:56900;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"WEISS, MICHAEL AARON;",1863443;,3R01DK079233,01/15/2010,06/30/2010,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; Absorption; Active Follow-up; Adhesives; Affinity; Agitation; Air; Animals; Arizona; Artificial Endocrine Pancreas; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Biophysics; Blood Glucose; Blood Sugar; C-Peptide; Carbol; Carbolic Acid; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Culture Techniques; Cell Nucleus; Chemicals; Chemistry, Biological; Chimera; Chimera organism; Clinical; Clinical Investigator; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Common Rat Strains; Connecting Peptide; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cystine; Data; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Dimerization; Disease; Disorder; Doctor of Medicine; Drug Formulations; Drug Kinetics; Electron Microscopy; Employee Strikes; Endocrine Pancreas, Artificial; Epidemiology; Event; Excitement, Psychomotor; Exhibits; FDA approved; Family suidae; Figs; Figs - dietary; Fluorescence Spectroscopy; Formulation; Formulations, Drug; Foundations; Future; Genetic Engineering of Proteins; Glass; Glycerin; Glycerol; Goals; Greater sac of peritoneum; Hepatic; Human; Human, General; Humulin R; Hydroxybenzene; Hypoglycemia; IDD; IDDM; IGF Receptor; IGF-1; IGF-1 Receptor; IGF-I; IGF-I-SmC; IGF1; IGF1R; INFLM; INSR; Implant; Implantable Pump; In Vitro; Incidence; Inflammation; Injection of therapeutic agent; Injections; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Infusion Systems; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Insulin-Dependent Tyrosine Protein Kinase; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor 1 Receptor; Insulin-Like Growth Factor I; Insulin-Like Growth Factor Receptor; Insulin-Like Somatomedin Peptide I; Insulin-Like-Growth Factor I Receptor; Intervention; Intervention Strategies; Isotopes; Kidney Diseases; Kidney Failure; Kidney Insufficiency; Knowledge; L-Cystine; Label; Length; Letters; Liquid substance; M.D.; MODY; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mechanics; Mediating; Microscopy; Modeling; Molecular; Molecular Interaction; NIDDM; NMR Spectroscopy; Nephropathy; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nucleus; Obstruction; Oranges; Organ System, Cardiovascular; Outcome; Patients; Peritoneal; Peritoneal Cavity; Pharmacokinetics; Phenols; Physiologic; Physiological; Pigs; Play; Preparation; Problem Solving; Process of absorption; Proinsulin; Property; Property, LOINC Axis 2; Protein Dimerization; Protein Engineering; Proteins; Psychomotor Agitation; Psychomotor Hyperactivity; Psychomotor Restlessness; Pump; Rat; Rattus; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Receptors, Somatomedin; Recipe; Refractory; Relative; Relative (related person); Renal Disease; Renal Failure; Renal Insufficiency; Replacement Therapy; Research; Resistance; Resolution; Restlessness; Retinal Diseases; Retinal Disorder; Risk; Safety; Series; Single Crystal Diffraction; Site; Solid; Solutions; Solvents; Somatomedin C; Spectroscopy, Fluorescence; Spectroscopy, NMR; Strikes; Strikes, Employee; Structure; Study Section; Suidae; Surface; Swine; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; T2D; T2DM; Technology; Testing; Time; Translations; Type 1 diabetes; Type 2 diabetes; Type II diabetes; United Kingdom; Universities; Vascular, Heart; Wound Healing; Wound Repair; X Ray Crystallographies; X-Ray Crystallography; Zinc; Zn element; aberrant protein folding; abnormal protein folding; absorption; adult onset diabetes; aminoacid sequence of peptide; aminoacid sequence of protein; amyloid assembly; amyloid formation; amyloidogenesis; analog; base; blood glucose regulation; brain amyloidogenesis; chemical synthesis; circulatory system; clinical investigation; cross-link; crosslink; design; designing; diabetes; diabetes control; diabetes-associated neuropathy; disease/disorder; engineered pancreas; fluid; follow-up; frontier; gene product; globular protein; glucose control; glucose homeostasis; glucose pump; glucose regulation; glycemic control; hypoglycemic; hypoglycemic episodes; in vitro Assay; in vivo; innovate; innovation; innovative; insulin dependent diabetes; insulin pump; interest; interventional strategy; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; kidney disorder; liquid; maturity onset diabetes; meetings; microvascular complications; microvascular complications of diabetes; microvascular disease; mini-proinsulin; miniproinsulin; monomer; new approaches; novel; novel approaches; novel strategies; novel strategy; nuclear magnetic resonance spectroscopy; pathologic protein folding; peptide sequence; polypeptide; porcine; prevent; preventing; prospective; protein aggregation; protein aminoacid sequence; protein mis-folding; protein misfolding; protein structure; psychologic; psychological; public health relevance; receptor binding; renal disorder; resistant; retina disease; retina disorder; retinopathy; small molecule; solid state nuclear magnetic resonance; success; suid; surfactant; therapeutic protein; tissue repair; trend; type I diabetes",Design of an Implantable Pump Insulin,"PUBLIC HEALTH RELEVANCE: The central objective of insulin replacement therapy in the treatment of Diabetes is glycemic control, i.e., regulation of blood glucose to near-physiological levels. The clinical importance of this tight control has motivated extensive efforts to develop an insulin pump implanted in the body to provide regulated peritoneal delivery of insulin; however, to date, implantable pumps remain experimental due to pump blockage associated with insulin aggregation. The objective of this application is to design an optimal insulin analog for safe and effective use in an implantable pump.",79233,ZRG1,Special Emphasis Panel,S1,2,56900,
8009927,R01,DK,3,Y,01/18/2010,12/31/2010,PA-06-169,3R01DK079361-12S2,,NIDDK:99875;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PEDIATRICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"PALIS, JAMES ;",1888553;,3R01DK079361,01/18/2010,12/31/2010,"21+ years old; Adhesion Molecule; Adhesions; Adult; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Circulation; Blood Precursor Cell; Blood erythrocyte; Blood megakaryocyte; Blood normocyte; Bloodstream; CXC-R4; CXCL12 protein; CXCR-4; CXCR4; CXCR4 gene; Cardiac; Cell Adhesion Molecules; Cells; Chemoattractants; Chemokine (C-X-C Motif) Ligand 12; Chemotactic Factors; Chemotaxins; Chemotaxis; Circulation; Clinical; Cytokines, Chemotactic; D2S201E; Data; Defect; Embryo; Embryonic; Erythroblasts; Erythrocytes; Erythrocytes, Nucleated; Erythrocytic; Erythroid; Erythroid Cells; Erythropoiesis; Event; FB22; FLR; Failure (biologic function); Fetal Liver; Fetus; Funding; Generalized Growth; Globin; Grant; Growth; HM89; HSY3RR; Hematologic Body System; Hematopoiesis; Hematopoietic; Hematopoietic Body System; Hematopoietic Cellular Control Mechanisms; Hematopoietic System; Hematopoietic stem cells; Homologous Chemotactic Cytokines; Human, Adult; In Vitro; Intercrines; Investigation; Investigators; Island; Kinetic; Kinetics; Kupffer Cells; LAP3; LCR1; LESTR; Laboratories; Lead; MYB; MYB gene; Mammals, Mice; Marrow erythrocyte; Mediating; Megakaryocytes; Megalokaryocyte; Mice; Modeling; Molecular; Mother Cells; Murine; Mus; NPY3R; NPYR; NPYRL; NPYY3R; Normoblasts; Nuclear; Nucleated red blood cell; Nucleated red cell; O element; O2 element; Organ System, Hematologic; Oxygen; Pb element; Phagocytosis; Play; Population; Pre-B Cell Growth Stimulating Factor; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Proto-Oncogene Products c-myb; Proto-Oncogene Proteins c-myb; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research Personnel; Researchers; Reticuloendothelial System, Erythrocytes; Role; SDF-1; SDF-1alpha; SIS cytokines; Sdf1 protein; Seminal; Staging; Stellate Sinusoidal Macrophage; Stem cells; Stimulus; Stromal Cell-Derived Factor 1; Structure; Testing; Time; Tissue Growth; V-Myb Myeloblastosis Viral Oncogene Homolog; Yolk Sac; adult human (21+); blood corpuscles; c myb; c-Myb; c-myb Gene; c-myb Proteins; c-myb Proto-Oncogenes; cell adhesion protein; chemoattractant cytokine; chemokine; chemokine receptor; complement chemotactic factor; failure; hIRH; heavy metal Pb; heavy metal lead; in vivo; liver macrophage; macrophage; migration; myb Proto-Oncogene Proteins; nucleated RBCs; ontogeny; p-Globin; progenitor; programs; reconstitute; reconstitution; response; social role; stem; stromal cell-derived factor-1alpha; vitelline sac",Initiation of Mammalian Embryonic Hematopoiesis,,79361,ELB,Erythrocyte and Leukocyte Biology Study Section,S2,12,99875,
7998749,R01,DK,3,,01/20/2010,01/19/2011,DK-06-016,3R01DK079667-04S2,,NIDDK:92400;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"SALIM, ALI ;",8825830;,3R01DK079667,08/01/2007,07/31/2012,"Accounting; Address; African American; Afro American; Afroamerican; American; Attitude; Awareness; Awarenesses; Black Populations; Black or African American; California; Clergy; Clinic; Code; Coding System; Communities; Consent; County; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Development; Disease Frequency Surveys; Donor, Organ; Effectiveness; Effectiveness, Program; Ethnic group; Evaluation; Family; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Hispanic Americans; Hispanic Populations; Hispanics; Hispanics or Latinos; Latino Population; Life; Los Angeles; Measures; Media Campaign; Medical center; Methods; Minority; Motor Vehicles; Observational Study; Organ; Organ Donations; Organ Donor; Organ Procurements; Paper; Patients; Physicians; Play; Population; Population Growth; Primary Care; Primary Health Care; Primary Healthcare; Principal Investigator; Program Effectiveness; Programs (PT); Programs [Publication Type]; Registries; Role; Services; Source; Spanish Americans; Spanish Origin; Specific qualifier value; Specified; Spottings; Students; Survey Instrument; Surveys; System; System, LOINC Axis 4; TV; Target Populations; Television; Tissue Donations; Tissue Donors; Transplantation; United States; Universities; Waiting Lists; Work; base; black American; high school; hispanic community; programs; prospective; social role; stem; transplant",Increasing Organ and Tissue Donation in Hispanic Americans,,79667,ZDK1,Special Emphasis Panel,S2,4,92400,
8004340,R01,DK,3,Y,01/22/2010,01/21/2011,PA-07-070,3R01DK079892-01A2S1,,NIDDK:99850;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LITTLE ROCK,UNITED STATES,BIOCHEMISTRY,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"MOCK, DONALD M;",7744031;,3R01DK079892,01/22/2010,01/21/2011,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 3-hydroxy-3-methylbutyric acid; 3-hydroxyisovaleric acid; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Address; Animals; Biotin; Biotinylation; Birth Defects; Blood; Blotting, Western; CREA; Care, Health; Common Rat Strains; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Consent; Control Groups; Correlation Studies; Creatinine; Enzymes; Excretory function; Funding; Gene Expression; Gestation; HMB-d6; Healthcare; Human; Human, General; In Vitro; Intervention; Intervention Strategies; Intervention Trial; Mammalia; Mammals; Mammals, General; Mammals, Rats; Man (Taxonomy); Man, Modern; Molecular Genetic Abnormality; Normal Range; Normal Values; PBL; PBO; Peripheral Blood Lymphocyte; Phase; Phlebotomy; Placebo Control; Placebos; Pregnancy; Pregnant Women; Propionyl-CoA Carboxylase; Propionyl-Coenzyme A Carboxylase; Qualifying; Randomized; Rat; Rattus; Renal function; Research; Reticuloendothelial System, Blood; Role; Sampling; Sham Treatment; Statistical Correlation; Supplementation; Testing; Time; Urinary System, Urine; Urine; Venous blood sampling; Vitamin H; Western Blotting; Western Blottings; Western Immunoblotting; Woman; beta-hydroxy-beta-methylbutyrate; beta-hydroxyisovaleric acid; biotin holocarboxylase synthetase; coenzyme R; design; designing; excretion; falls; holocarboxylase synthetases; holoenzyme synthetase; human subject; indexing; interventional strategy; kidney function; methylmalonyl-CoA decarboxylase; pregnant; protein blotting; protein expression; public health relevance; randomisation; randomization; randomly assigned; sham therapy; social role; urinary",Biotin Status in Pregnancy,"  Relevance: We are concerned that marginal biotin deficiency causes human birth defects. Here we seek funding to demonstrate that marginal biotin deficiency is common in pregnancy. If so, then the next logical question would be ""Does marginal biotin deficiency cause a substantial number of human birth defects?"" Large-scale epidemiologic correlation studies, a large-scale biotin intervention trial or both would be needed to answer that question. Given the expense of such trials, the smaller study proposed here is an essential prerequisite in a line of research with substantial healthcare implications.",79892,INMP,Integrative Nutrition and Metabolic Processes Study Section,A2S1,1,99850,
8009562,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK079979-02S2,,NIDDK:16500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,SURGERY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"WORRELL, ROGER T;",6206701;,3R01DK079979,01/07/2010,12/31/2010,"3'5'-cyclic ester of AMP; ATP phosphohydrolase; ATP phosphohydrolase (Na+ K+ transporting); ATPase; Absorption; Acids; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Triphosphatase; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenosinetriphosphatase; Adverse effects; Affect; Agonist; Alimentary Canal; Ammonia; Ammonium; Apical; Assay; Attention; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood; Blood Circulation; Bloodstream; Body Tissues; Brain; Cell Line; Cell Lines, Strains; CellLine; Cells; Circulation; Cola; Colon; Constipation; Cyclic AMP; Data; Development; Diarrhea; Dietary Proteins; Digestive Diseases; Digestive System Diseases; Digestive System Disorders; Digestive Tract; Disease; Disorder; Distal; Duct; Duct (organ) structure; Encephalon; Encephalons; Encephalopathies; Enterocytes; Environment; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Equilibrium; Exposure to; Family; Fishes; GI Tract; Gases; Gastrointestinal Tract; Gastrointestinal tract structure; Genetics, in situ Hybridization; Genus Cola; Gills; Glycoproteins; Goals; Gut Epithelium; Helicobacter Infections; Helicobacter Pylori Infection; Hepatic; Hepatic Disorder; Hepatic Encephalopathy; Hepatic Failure; Hepatocerebral Encephalopathy; Heterogeneity; Human; Human, General; Hyperammonemia; In Situ Hybridization; Intestinal; Intestines; Ion Transport; Ions; Kidney; Knowledge; Learning; Left; Length; Life; Liquid substance; Literature; Liver Failure; Liver diseases; Macaca mulatta; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Membrane; Methylamines; Mice; Mice, Transgenic; Model System; Modeling; Models, Biologic; Molecular; Murine; Mus; NHE2; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Na+ K+ ATPase; Nephrons; Nervous System, Brain; Organ; Pathogenesis; Pathway interactions; Pattern; Permeability; Physiologic; Physiological; Portal Vein; Portal vein structure; Portal-Systemic Encephalopathy; Portosystemic Encephalopathy; Potassium Pump; Process; Process of absorption; RT-PCR; RTPCR; Regulation; Relative; Relative (related person); Reticuloendothelial System, Blood; Reverse Transcriptase Polymerase Chain Reaction; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Route; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump; Structure of intestinal epithelium; Surface; Time; Tissues; Transgenic Mice; Treatment Side Effects; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; Uriniferous Tube; Villus; absorption; adenosine 3'5' monophosphate; alimentary tract; aminomethane; apical membrane; balance; balance function; base; bowel; cAMP; cell type; colonic crypt; crypt cell; cultured cell line; deltapH; digestive canal; digestive disorder; disease/disorder; fluid; gastrointestinal epithelium; hepatic coma/encephalopathy; hepatopathy; improved; in situ Hybridization Staining Method; inhibitor; inhibitor/antagonist; insight; interest; intestinal epithelium; laser capture microdissection; liquid; liver disorder; membrane structure; methanamine; methylamine; methylamine bisulfite; monomethylamine; pH gradient; pH, delta; pathway; public health relevance; renal; reverse transcriptase PCR; side effect; social role; sodium potassium exchanging ATPase; therapy adverse effect; treatment adverse effect; uptake",Intestinal Epithelia Ammonium Transport,,79979,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,S2,2,16500,
8007017,R01,DK,3,Y,01/10/2010,12/31/2010,PAR-07-024,3R01DK080020-02S1,,NIDDK:77817;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ZELLER, MARGARET H;",2792905;,3R01DK080020,01/10/2010,12/31/2010,"12-20 years old; 21+ years old; Accounting; Adaptation, Psychologic; Adaptation, Psychological; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Age; Alcohols; Ancillary Study; Award; Bariatrics; Benefits and Risks; Binge Eating; Body Image; Body Weight decreased; Care Givers; Caregivers; Chemical Class, Alcohol; Comorbidity; Competence; Data; Data Collection; Data Element; Deceleration; Depression; Development; Distress; Documentation; Drugs; Dysfunction; Eating Behavior; Elements; Emotional; Emotional Depression; Family; Functional disorder; Grant; Health; Health Status; Human, Adult; Impairment; Individual; Investigators; Level of Health; Literature; Longitudinal Studies; Measurement; Measures; Medication; Mental Depression; Methods; Monitor; Morbid Obesity; NIDDK; Names; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Obesity; Obesity, Morbid; Observational Study; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Measure; Parents; Participant; Patient Self-Report; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Pilot Projects; Post-Operative; Postoperative; Postoperative Period; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychological adjustment; Psychopathology; Public Health Service; Public Health Service (U.S.); QOL; Quality of life; Recruitment Activity; Relative; Relative (related person); Research; Research Design; Research Personnel; Researchers; Resolution; Resource Sharing; Risk; Risk Behaviors; Risky Behavior; Safety; Self-Report; Series; Severe obesity; Sex Behavior; Sexual Activity; Sexual Behavior; Site; Smoke; Social support; Source; Staging; Study Type; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Symptoms of depression; Teen; Teenagers; Teens; Time; USPHS; United States Public Health Service; Variant; Variation; Weight Loss; Weight Reduction; Work; abnormal psychology; adiposity; adolescence (12-20); adolescent trauma; adult human (21+); at risk behavior; bariatric surgery; base; body weight loss; career; childhood trauma; cohort; comparative; comparison group; compulsive eating; compulsive feeding; compulsive overeating; corpulence; corpulency; corpulentia; depressive; depressive symptoms; design; designing; drug/agent; emerging adulthood; experience; gastric banding; gastric bypass surgery; high risk; high risk behavior; implantable gastric stimulation banding; infancy; infantile; innovate; innovation; innovative; interpersonal competence; interpersonal competency; juvenile; juvenile human; long-term study; longitudinal design; novel; obese; obese people; obese person; obese population; obesity surgery; obesity, extreme; pathophysiology; pediatric trauma; peer victimization; pilot study; programs; prospective; psychosocial; recruit; sex activity; social; social competence; social competency; social skills; social support network; stomach stapling; study design; surgery; surgical research; teen years; teenage; weight loss surgery; wt-loss",Adolescent Bariatrics: Controlled Longitudinal Study of Psychosocial Development,,80020,ZDK1,Special Emphasis Panel,S1,2,77817,
8003286,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-070,3R01DK080147-02S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,PEDIATRICS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"JHALA, ULUPI S;",7631756;,3R01DK080147,02/01/2010,04/30/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; AKT; APF-1; ATP-Dependent Proteolysis Factor 1; Acceleration; Active Oxygen; Address; Agonist; Akt protein; Amino Acid Sequence; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Apoptosis; Apoptosis Antigen Ligand 1; Apoptosis Pathway; Apoptotic; Area; Aspartic Acid; Autoimmune; Autoimmune Process; BAX; BAX gene; BCL2-Associated X Protein Gene; BCL2L4; Beta Cell; Biological; Blood leukocyte; CD178 Antigen; CD95 Ligand; CD95 antigen ligand; Cachectin; Cachectin-Tumor Necrosis Factor; Causality; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cellular Stress; Ceramide (lipids); Ceramides; Cessation of life; DIF; DNA; Death; Deoxyribonucleic Acid; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; Etiology; Event; Family; Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Genetic; Glossary; Grant; HMG-20; Hand; Hepatocyte Nitric Oxide Synthase; High Mobility Protein 20; Humulin R; IDD; IDDM; IL-1; IL1; INOS; INSR; Inbred NOD Mice; Inducible Nitric Oxide Synthase; Infiltration; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Insulin-Dependent Tyrosine Protein Kinase; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; JN kinase kinase; JNK; JNK kinase; JNK-activating protein kinase; JNK1; JNK1A2; JNK21B1/2; JNKK; Jun amino-terminal kinase kinase; Kinases; L-Aspartic Acid; L-Proline; L-Serine; L-Threonine; Lead; Leucine Zippers; Leukocytes; Link; Lymphocyte-Stimulating Hormone; MAP Kinase 8 Gene; MAP Kinase Kinase Kinase; MAP Kinase Kinases; MAP3 Kinases; MAPK Kinases; MAPK8; MAPK8 gene; MAPKKKs; MAPKKs; MLK-3 protein; MODY; MTGN; Macropain; Macrophage Cell Factor; Macrophage Nitric Oxide Synthase; Macroxyproteinase; Maps; Marrow leukocyte; Maturity-Onset Diabetes Mellitus; Mediating; Mice, Inbred NOD; Mitochondria; Mitogen-Activated Protein Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogens; Modeling; Molecular; Molecular Biology, Protein Sequencing; Mouse, NOD; Multicatalytic Proteinase; NIDDM; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide Synthase 2A; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; Oxidative Stress; Oxygen Radicals; PKB protein; PRKM8; Pancreatic beta Cell; Pathway interactions; Pb element; Peptide Sequence Determination; Peptides; Phosphorylation; Phosphotransferases; Play; Polyubiquitination; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Predisposition; Pro-Oxidants; Proline; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Kinase B; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Sequencing; Protein Structure, Primary; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteosome; Proto-Oncogene Proteins c-akt; RAC-PK protein; Reactive Oxygen Species; Regulation; Research; Reticuloendothelial System, Leukocytes; Role; SAPK1; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Stress; Structure of beta Cell of islet; Susceptibility; T Helper Factor; T1 diabetes; T1D; T1DM; T2D; T2DM; TNF; TNF (unspecified); TNF A; TNF Receptor Ligands; TNF gene; TNF-alpha; TNFSF2; Terminology; Therapeutic Intervention; Threonine; Time; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Gene; Tumor Necrosis Factor Ligand Superfamily Member 6; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Type 1 diabetes; Type 2 diabetes; Type II diabetes; UV damage; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; White Blood Cells; White Cell; adult onset diabetes; attenuation; base; biological signal transduction; c-akt protein; cytokine; db/db mouse; diabetes; diabetic; disease causation; disease etiology; disease/disorder etiology; disorder etiology; gene product; heavy metal Pb; heavy metal lead; human NOS2A protein; iNOS enzyme; inhibitor; inhibitor/antagonist; insulin dependent diabetes; intervention therapy; islet; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; lymphocyte activating factor; maturity onset diabetes; mitochondrial; mixed lineage kinase 3; model organism; multicatalytic endopeptidase complex; necrocytosis; nitric oxide synthase, Type II; pancreas beta cell; pathway; protein sequence; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; response; social role; tumor necrosis factor (unspecified); type I and type II diabetes; type I diabetes; type I diabetic; ubiquination; ubiquitin conjugation; ultra violet damage; ultraviolet damage; upstream kinase; white blood cell; white blood corpuscle",Signaling Cascades in Regulation of Pancreatic Beta cell mass.,,80147,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,2,100000,
8003283,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-054,3R01DK080165-02S1,,NIDDK:84744;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,,53,603880287,US,CA,92037,LA JOLLA INST FOR ALLERGY & IMMUNOLGY,"BARRIOS, AMY M;BOTTINI, NUNZIO  (contact);",1975323;7646958 (contact);,3R01DK080165,02/01/2010,04/30/2010,"Assay; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Cancer Treatment; Cancers; Cells; Collection; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Cytofluorometry, Flow; Cytosolic Protein Tyrosine Phosphastase; Detection; Development; Diabetes Mellitus; Docking; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Editorial Comment; Editorial Comment (PT); Enzymes; Faculty; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Future; High Throughput Assay; Housing; Human; Human, General; In Vitro; Individual; L-tyrosine, dihydrogen phosphate (ester); Lead; Libraries; Life; Lymphoid; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods; Microfluorometry, Flow; Modeling; Molecular Bank; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); PTP-1B; PTP1B; PTPN1; PTPN1 gene; PTPase; Patients; Pb element; Peptide Library; Peptides; Phosphates; Phosphotyrosine; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Prevention; Propionic Acids; Protein Tyrosine Phosphatase; Protocol; Protocols documentation; Published Comment; Recombinants; Screening procedure; Specificity; Surface; Testing; Therapeutic; Translating; Translatings; Tyrosine Phosphatase; Tyrosine-O-phosphate; Tyrosyl Phosphoprotein Phosphatase; United States National Institutes of Health; Viewpoint; Viewpoint (PT); Work; analog; anticancer therapy; autoimmune disorder; base; cancer therapy; diabetes; flow cytophotometry; heavy metal Pb; heavy metal lead; high throughput screening; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; inorganic phosphate; language translation; malignancy; mouse model; neoplasm/cancer; nitrophenylphosphate; novel; phosphatase inhibitor; protein tyrosine phosphate phosphohydrolase; screening; screenings; self recognition (immune); small molecule; virtual",Fluorogenic Assays for Cell-based HTS of Tyrosine Phosphatase Inhibitors,,80165,ISD,Instrumentation and Systems Development Study Section,S1,2,84744,
7998076,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK080345-02S1,,NIDDK:42152;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SAUPE, KURT WILLIAM;",1897625;,3R01DK080345,01/15/2010,03/31/2010,"5'-Adenylic acid; ACRP30 protein; ATP-protein phosphotransferase; Adenosine Monophosphate; Adenylic Acid; Adipocytes; Adipose Cell; Adipose Tissue, Brown; Adipose tissue; Adrenergic Agents; Adrenergic Agonists; Adrenergic Drugs; Adrenergic Receptor; Adrenergic Receptor Agonist; Adrenergics; Adrenoceptors; Adrenomimetics; Age; Autonomic nervous system; Biogenesis; Biological Function; Biological Process; Biopsy; Blood; Body Tissues; Body Weight; Brown Fat; Caloric Intake; Calories; Cell Communication and Signaling; Cell Signaling; Centrifugation; Chronic; Data; Development; Diet; Down-Regulation; Down-Regulation (Physiology); Downregulation; Energy Intake; Epidemic; Equilibrium; Esthesia; Expenditure; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Fractionation, Centrifugation; Goals; Health; Heat Production; Heating; Hibernating Gland; Human; Human, General; Humulin R; Hunger; Hypothalamic structure; Hypothalamus; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Knockout Mice; Leptin; Link; Lipocytes; Liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Measures; Mediating; Metabolic syndrome; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Molecular; Murine; Mus; Muscle; Muscle Tissue; Novolin R; Null Mouse; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Origin of Life; Patients; Phosphorylation; Play; Production; Protein Kinase; Protein Phosphorylation; Publishing; Pump; Receptors, Epinephrine; Regulation; Research; Reticuloendothelial System, Blood; Role; SNS; Sensation; Shivering; Shiverings; Signal Transduction; Signal Transduction Systems; Signaling; Sympathetic Nervous System; System; System, LOINC Axis 4; Temperature; Testing; Thermogenesis; Tissues; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; Weight Gain; Weight Increase; adenoreceptor; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adipose; adiposity; adrenergic; apM-1 protein; apM1 (adipose-specific) protein; balance; balance function; biological signal transduction; body system, hepatic; body weight gain; body weight increase; caloric dietary content; calorie (nutrition); cell type; clinical applicability; clinical application; combat; corpulence; corpulency; corpulentia; desensitization; diet and exercise; energy balance; glycogen synthase a kinase; hydroxyalkyl protein kinase; hypothalamic; in vivo; insulin sensitivity; mitochondrial; novel; ob/ob mouse; obese; obese people; obese person; obese population; organ system, hepatic; phosphorylase b kinase kinase; prevent; preventing; public health relevance; sex; social role; white adipose tissue; wt gain; yellow adipose tissue",Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis,,80345,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,2,42152,
8010998,R01,DK,3,Y,02/01/2010,07/31/2010,PA-07-056,3R01DK080730-02S1,,NIDDK:19547;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,SURGERY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"PARSONS, MICHAEL ;",8631918;,3R01DK080730,02/01/2010,07/31/2010,"1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 2-Methyl-5-nitroimidazole-1-ethanol; Ablation; Abscission; Anaplastic; Apoptosis; Apoptosis Pathway; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; B9 endocrine pancreas; Beta Cell; Biological Models; Biology; Brachydanio rerio; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Lineage; Cell Signaling; Cells; Cellular biology; Chemicals; Collaborations; Complement; Complement Proteins; Complex; Cytotoxin; Danio rerio; Data; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Drug Evaluation, Preclinical; Drug Precursors; Drug Screening; Drugs; E coli Proteins; Embryo; Embryonic; Endocrine; Enzymes; Escherichia coli Proteins; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Excision; Extirpation; Flagyl; Fluorescence; Funding; Future; Gastrointestinal Tract, Pancreas; Gene Targeting; Genes; Genetic; Genetic Techniques; Grafting, Islets of Langerhans; Hand; Hour; Human; Human, General; Humulin R; IDD; IDDM; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Inbred NOD Mice; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cell; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Knowledge; Label; Letters; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medication; Methods; Methods and Techniques; Methods, Other; Metro I.V.; Metronidazole; Mice; Mice, Inbred NOD; Model System; Models, Biologic; Molecular; Mother Cells; Mouse, NOD; Murine; Mus; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Natural immunosuppression; Natural regeneration; Nesidioblasts; Nitroreductases; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Notch Signaling Pathway; Novolin R; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiology; Population; Preclinical Drug Evaluation; Pro-Drugs; Prodrugs; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteolysis and Signaling Pathway of Notch; Protocols, Treatment; RGM; Recovery; Regeneration; Regimen; Removal; Research; Role; Satric; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Stem cells; Study models; Surgical Removal; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Targetings, Gene; Technics, Genetic; Techniques; Testing; Therapeutic; Therapeutic Agents; Thymus-Dependent Lymphocytes; Time; Transgenes; Transgenic Organisms; Transplantation; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Treatment Protocols; Treatment Regimen; Treatment Schedule; Type 1 diabetes; Undifferentiated; Zebra Danio; Zebra Fish; Zebrafish; abstracting; base; beta cell development; biological signal transduction; cell biology; design; designing; diabetes; diabetic patient; disease/disorder; drug/agent; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; immunosuppression; insight; insulin dependent diabetes; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; necrocytosis; notch; notch protein; notch receptors; novel; pancreas development; pathway; progenitor; regenerate; regenerative; research study; resection; self recognition (immune); self-renewal; social role; thymus derived lymphocyte; tool; transgenic; transplant; type I diabetes; type I diabetic",Identifying the progenitors responsible for Beta Cell regeneration in zebrafish,,80730,DEV1,Development - 1 Study Section,S1,2,19547,
8009385,R01,DK,3,Y,01/08/2010,03/31/2010,PA-07-070,3R01DK080746-02S1,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"XU, HAIYAN ;",8615883;,3R01DK080746,01/08/2010,03/31/2010,"21+ years old; Adenoviridae; Adenoviruses; Adult; Affect; Amplifiers; Animals; Antimorphic mutation; Arm; Assay; Attenuated; Bioassay; Biologic Assays; Biological Assay; Blood Glucose; Blood Sugar; Cells; Chemotherapy-Hormones/Steroids; D-Glucose; DUSP6 protein; Data; Dephosphorylation; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7.2-; Endocrine Gland Secretion; Enzyme Gene; Extracellular Signal-Regulated Kinases; Fasting; Fats; Fatty acid glycerol esters; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Gluconeogenesis; Glucose; Goals; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hormones; Human, Adult; Humulin R; Hyperglycemia; Hypoglycemia, Fasting; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin Signaling Pathway; Insulin, Regular; Liver; Liver Cells; MAP kinase; MAP kinase phosphatase 3; MAPK; MKP-3 protein, human; MODY; Mammals, Mice; Mammals, Rodents; Maturity-Onset Diabetes Mellitus; MeSH Descriptors Class 4; Mediating; Metabolic; Mice; Mice, Obese; Mitogen-Activated Protein Kinases; Molecular; Murine; Mus; Muscle; Muscle Tissue; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nuclear; Nuclear Translocation; Obese Mice; Obesity; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); PEPCK; Pathway interactions; Phosphatases; Phosphoenolpyruvate Carboxylase; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postabsorptive Hypoglycemia; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Phosphorylation; Proteins; Pyst1 protein; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reporter; Repression; Research; Rodent; Rodentia; Rodentias; Role; Sequence-Specific Posttranscriptional Gene Silencing; Societies; T2D; T2DM; Therapeutic Hormone; Transcription; Transcription, Genetic; Type 2 diabetes; Type II diabetes; Upper arm; Youth; Youth 10-21; adiposity; adult human (21+); adult onset diabetes; body system, hepatic; corpulence; corpulency; corpulentia; diabetic; fasted; fasting blood glucose level; fasts; fork head protein; forkhead protein; forkhead transcription factors; gene product; geographic site; glucose RA; glucose biosynthesis; glucose disposal; glucose output; glucose production; glucose rate of appearance; glycemic control; hyperglycemic; in vivo; insulin resistant; insulin signaling; insulin stimulated glucose disposal; ketosis resistant diabetes; knock-down; loss of function; maturity onset diabetes; mitogen-activated protein kinase phosphatase-3, human; new therapeutic target; novel; obese; obese people; obese person; obese population; organ system, hepatic; overexpression; pathway; phosphoenolpyruvate carboxykinase; programs; public health relevance; response; social role",MAP Kinase Phosphatase 3 (MKP-3) and Obesity-related Gluconeogenesis," Project narrative Obesity-related type 2 diabetes, featured with decreased body response to insulin, is attributable to increased liver glucose production and decreased glucose utilization by muscle and fat. A novel factor was recently found to elevate in the liver of obese rodents, antagonize the action of insulin in the liver, promote liver glucose production and contribute significantly to hyperglycemia in obesity. Results generated from research outlined in this proposal will provide key information to understand the mechanism of action of this protein and evaluate its candidacy as a new therapeutic target for treating obesity-related type 2 diabetes.",80746,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,2,100000,
8010060,R01,DK,3,Y,01/20/2010,12/31/2010,PA-07-011,3R01DK080750-03S1,,NIDDK:100001;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,PEDIATRICS,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"CIVIN, CURT I;",1866174;,3R01DK080750,01/20/2010,12/31/2010,"21+ years old; 3' Untranslated Regions; 3'UTR; Abbreviations; Adult; Affect; Applications Grants; Binding; Binding (Molecular Function); Bio-Informatics; Bioinformatics; Biology; Blood Precursor Cell; Blood erythrocyte; Blood granulocytic cell; Blood megakaryocyte; Blood normocyte; Bone Marrow; CD34; CD34 gene; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Common Lymphoid Progenitor; Data; Development; Development and Research; Electronics; Embryo; Embryonic; Erythrocytes; Erythrocytic; Erythroid; Erythroid Cells; Erythroid Precursor Cells; Erythroid Progenitor Cells; Erythropoiesis; Erythropoietic Stem Cells; Event; Figs; Figs - dietary; Genes; Grant Proposals; Grants, Applications; Granular Leukocytes; Granulocytic cell; HPCA1; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Human; Human, Adult; Human, General; Immunologic, Luciferase; Individual; Lead; Longitudinal Studies; Luciferases; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mediating; Megakaryocytes; Megalokaryocyte; Messenger RNA; Mice; Micro RNA; MicroRNAs; Modeling; Molecular; Molecular Interaction; Molecular Target; Mother Cells; Multipotent Stem Cells; Murine; Mus; Myelogenous; Myeloid; Myelopoiesis; Oranges; Pathway interactions; Pb element; Play; Progenitor Cells; Progenitor Cells, Erythropoietic; Progenitor Cells, Hematopoietic; Proteins; Publishing; R & D; R&D; RNA, Messenger; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Reporting; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Erythrocytes; Role; Site; Specific qualifier value; Specified; Staging; Stem Cells, Erythroid; Stem cells; Subcellular Process; Thermodynamic; Thermodynamics; Translational Inhibition; Translational Repression; Translations; adult human (21+); adult stem cell; base; blood corpuscles; cellular development; clinical applicability; clinical application; cultured cell line; gene product; granulocyte; hESC; heavy metal Pb; heavy metal lead; human ES cell; human ESC; human embryonic stem cell; long-term study; mRNA; mRNA Expression; macrophage; miRNA; multipotent progenitor; novel; pathway; peripheral blood; progenitor; research and development; social role; stem; tool; translation assay",MicroRNAs regulating erythroid development,,80750,HP,Hematopoiesis Study Section,S1,3,100001,
8001143,R01,DK,3,Y,01/01/2010,03/31/2010,PA-07-070,3R01DK080784-02S1,,NIDDK:51256;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"MOORE, ANNA ;",6470568;,3R01DK080784,01/01/2010,03/31/2010,"Affect; Allogenic; Animals; Apopain; Apoptotic; Autoimmune; Autoimmune Process; B9 endocrine pancreas; Beta Cell; Blotting, Western; CAP4 protease; CASP-3; CASP3; CASP8 Protein; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase-8/Flice; Cell Death; Cessation of life; Clinical; Contrast Agent; Contrast Drugs; Contrast Media; Cysteine Protease CPP32; Death; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Enzymes; Evaluation; Experimental Designs; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Gene Inactivation; Gene Silencing; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic; Genetic Intervention; Goals; Grafting, Islets of Langerhans; Hepatotoxic effect; Hepatotoxicity; Histology; Human; Human, General; Humulin R; Hyperglycemia; IDD; IDDM; Image; Immune; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intervention, Genetic; Islands of Langerhans; Islet Cell; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Label; Length of Life; Link; Liver; Liver Toxicity; Longevity; MACH protein; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetism; Malignant Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mch5 protease; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mice; Modality; Modeling; Molecular Biology, Gene Therapy; Monitor; Murine; Mus; NMR Imaging; NMR Tomography; Nesidioblasts; Novolin R; Nuclear Magnetic Resonance Imaging; Outcome; PARP Cleavage Protease; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Patients; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Procedures; Property; Property, LOINC Axis 2; Proteins; Protocol; Protocols documentation; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Radiopaque Media; Resistance; SCA-1; SREBP Cleavage Activity 1; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Specificity; Susceptibility; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Therapy, DNA; Time; Toxic effect; Toxic effect on liver cells; Toxicities; Transplantation; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 1 diabetes; Western Blotting; Western Blottings; Western Immunoblotting; Yama; Yama protein; Zeugmatography; base; beta cell development; body system, hepatic; cancer cell; caspase-3; caspase-8; cysteine protease P32; diabetes; diabetic; diabetic patient; endocrine pancreas; endocrine pancreas development; experience; gene product; gene therapy; genetic therapy; hepatoxicity; hyperglycemic; imaging; imaging probe; improved; in vitro Model; in vivo; insulin dependent diabetes; insulin secretion; interest; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; life span; lifespan; magnetic; nano particle; nanoparticle; necrocytosis; novel; organ system, hepatic; prevent; preventing; protein blotting; public health relevance; resistant; siRNA; therapeutic gene; therapeutic target; transplant; tumor; type I diabetes; type I diabetic; uptake",Combined siRNA Therapy and In-vivo Imaging in Islet Transplantation,,80784,ZRG1,Special Emphasis Panel,S1,2,51256,
8012384,R01,DK,3,Y,02/01/2010,10/31/2010,PA-07-070,3R01DK080996-02S1,,NIDDK:98500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BHUSHAN, ANIL ;",1908847;,3R01DK080996,02/01/2010,10/31/2010,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 21+ years old; Address; Adult; Age; Aging; Animals; B9 endocrine pancreas; Beta Cell; CAPS; Capsules; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Therapy; Cells; Cellular Proliferation; Control Locus; Data; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetic mouse; Doxycycline; Engraftment; Exocrine pancreas; Fostering; GWAS; Genes; Glucose Intolerance; Grafting, Islets of Langerhans; Human, Adult; Humulin R; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Islands of Langerhans; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Knockout Mice; Life; Light; Link; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Metabolic; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Molecular Target; Mother Cells; Murine; Mus; NIDDM; Natural regeneration; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Photoradiation; Physiologic; Physiological; Polycomb; Population; Production; Progenitor Cells; Proliferating; Proteins; Public Health; Regeneration; Regulation; Relative; Relative (related person); Repression; Role; Senescence; Stem cells; T2D; T2DM; Testing; Therapy, Cell; Transgenic Mice; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; Vibramycin; adult human (21+); adult onset diabetes; age dependent; age related; alpha-6-Deoxyoxytetracycline; beta cell development; capsule (pharmacologic); cell type; cell-based therapy; derepression; design; designing; diabetes; diabetic patient; endocrine pancreas; endocrine pancreas development; flexibility; gain of function; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hematopoietic tissue; high risk; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; ketosis resistant diabetes; maturity onset diabetes; medical complication; member; mouse model; mouse model of diabetes; novel therapeutic intervention; pathway; premature; public health medicine (field); public health relevance; regenerate; regenerative; renal; senescence; senescent; social role; whole genome association studies; whole genome association study",Role of polycomb group gene Bmi-1 in beta cell regeneration and aging," RELEVANCE TO PUBLIC HEALTH As diabetic patients require life-long insulin therapy and have a high risk of medical complications, preventative or curative therapies are urgently needed. Diabetes results from an inadequate mass of functional beta cells and there is increasing evidence to suggests that beta cell proliferation, the dominant means by which beta cells adapt to changing metabolic demands, is related to aging. This proposal contends that understanding the mechanisms of age-dependent beta cell expansion could be useful for regenerate beta cells and such an approach that exploits the mechanisms involved in the expansion of beta cell mass due to physiologic demands will be critical in developing novel therapeutic approaches that involve beta-cell regeneration in diabetic patients.",80996,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,2,98500,
8003722,R01,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R01DK081009-02S1,,NIDDK:29000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"OZCAN, UMUT ;",9024810;,3R01DK081009,01/15/2010,03/31/2010,"Adenoviridae; Adenoviruses; Adipose tissue; Affect; Back; Butanoic Acids; Butyric Acids; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chaperone; Chemicals; Chiro-Inositol; Complex; Data; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dorsum; EC 2.7; Endoplasmic Reticulum; Enzymes; Epidemic; Ergastoplasm; Face; Fatty Tissue; Feedback; Generalized Growth; Genes; Genetically Engineered Mouse; Growth; Health; Human; Human, General; Humulin R; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRS kinase; IRS-1 protein; IRS1; IRS2; IRS2 gene; Incidence; Individual; Injection of therapeutic agent; Injections; Inositol; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor Substrate 1; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; KIAA0243; Kinases; Knock-out; Knockout; L-Serine; Liver; METBL; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Mesoinositol; Metabolic Processes; Metabolism; Mice; Modality; Molecular; Molecular Chaperones; Murine; Mus; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutrient; Obesity; Pathology; Pathway interactions; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Turnover; Proteins; RAFT-1 gene product; Role; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; T2D; T2DM; TSC1; TSC1 gene; TSC1/2; TSC1/2 gene; TSC1/TSC2; TSC2; TSC2 gene; TSC2/TSC1; Tail; Tissue Growth; Transphosphorylases; Tsc1 [{C0694894}]; Tuberous sclerosis protein complex; Tumor Suppressor Proteins; Type 2 diabetes; Type II diabetes; Tyrosine Phosphorylation; Veins; adipose; adiposity; adult onset diabetes; base; biological signal transduction; body system, hepatic; c jun; c-jun Gene; cardiovascular disorder; corpulence; corpulency; corpulentia; cultured cell line; disease/disorder; effective therapy; endoplasmic reticulum stress; facial; feeding; gene product; high risk; improved; in vivo; insulin receptor serine kinase; insulin receptor substrate 1 protein; insulin resistant; insulin signaling; ketosis resistant diabetes; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); maturity onset diabetes; mouse model; new therapeutics; next generation therapeutics; novel therapeutic intervention; novel therapeutics; obese; obese people; obese person; obese population; ontogeny; organ system, hepatic; pathway; protein degradation; recombinase; response; sensor; social role; tuberous sclerosis complex; tumor suppressor; white adipose tissue; yellow adipose tissue",The In Vivo Role of JNK-1 and IRS-1 Ser307 Phosphorylation In Development of Insu,,81009,MCE,Molecular and Cellular Endocrinology Study Section,S1,2,29000,
8010797,R01,DK,3,Y,01/18/2010,12/31/2010,PA-07-070,3R01DK081290-02S1,,NIDDK:99740;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,KANSAS CITY,UNITED STATES,BIOCHEMISTRY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"PETERSON, KENNETH R;",2096791;,3R01DK081290,01/18/2010,12/31/2010,"21+ years old; ANK Domain; ANK Repeat; Activation, Gene; Adult; Adverse effects; Affect; African American; Afro American; Afroamerican; Animal Model; Animal Models and Related Studies; Ankyrin Repeat; Ankyrin Repeat Domain; Antibodies; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Biochemical; Bioinformatics; Black Populations; Black or African American; Blood erythrocyte; Blood megakaryocyte; Blood normocyte; Body Tissues; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; CHIP assay; Cells; ChIP (chromatin immunoprecipitation); Chemicals; Chromosomes, Artificial, Yeast; Combining Site; Complementary DNA; Complex; Conceptus; Coupled; DNA; DNA Binding; DNA Binding Interaction; DNA Sequence; DNA, Complementary; DNA-Binding Proteins; Data; Deoxyribonucleic Acid; Development; Dimerization; Disease; Disorder; Elements; Erythrocytes; Erythrocytic; Erythroid; Erythroid Cells; Erythropoiesis; Expression Library; Expression Profiling; Expression Signature; Fetal Hemoglobin; Fetal Liver; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; GFP; Gene Action Regulation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, Switch; Genetic Condition; Genetic Diseases; Genetic Transcription; Genomics; Globin; Goals; Green Fluorescent Proteins; Hb SS disease; HbSS disease; Hemoglobin F; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hemoglobinopathies; Hemoglobinopathies / Iron Metabolism; Hereditary Disease; Human; Human, Adult; Human, General; Hydroxycarbamid; Hydroxycarbamide; Immune Precipitation; Immunoprecipitation; K562 Cells; Left; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediating; Megakaryocytes; Megalokaryocyte; Messenger RNA; Mice; Mice, Transgenic; Molecular; Molecular Disease; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Molecular Weight; Murine; Mus; N-terminal; NH2-terminal; Nuclear Extract; Nucleosomes; Patients; Pattern; Phenotype; Photometry/Spectrum Analysis, Mass; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Protein Dimerization; Proteins; RNA Expression; RNA, Messenger; Reactive Site; Recruitment Activity; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Reporter; Research; Reticuloendothelial System, Erythrocytes; Role; Sickle Cell; Sickle Cell Anemia; Sortings, Fluorescence-Activated Cell; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Structure; Switch Genes; System; System, LOINC Axis 4; TSPY; TSPY protein; TSPY protein, human; Testing; Testis Specific Protein, Y-Linked; Testis-Specific Y-Encoded Protein; Therapeutic; Therapeutic Intervention; Tissues; Trans-Acting Factors; Trans-Activation (Genetics); Trans-Activators; Transactivation; Transactivators; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transgenic Mice; Transgenic Organisms; Treatment Side Effects; Up-Regulation; Urea, hydroxy-; YAC Vector; Yang; adult human (21+); base; black American; blood corpuscles; blood vessel occlusion; cDNA; cDNA Expression; chromatin immunoprecipitation; cross-link; crosslink; disease/disorder; drepanocyte; effective therapy; experiment; experimental research; experimental study; fetal; fetal globin; gain of function; gel mobility shift assay; gene product; genetic disorder; hematopoietic tissue; hereditary disorder; human TSPY protein; hydroxyurea; in vivo; intervention therapy; knock-down; loss of function; mRNA; meetings; model organism; molecuar profile; molecular signature; mouse model; novel; p-Globin; palliative; prevent; preventing; protein complex; protein function; public health relevance; recruit; research study; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; side effect; social role; testis-specific protein Y; therapeutic target; therapy adverse effect; tool; trans acting factor (genetic); transcription factor; transgenic; treatment adverse effect",Transactivation of Fetal Hemoglobin,,81290,ELB,Erythrocyte and Leukocyte Biology Study Section,S1,2,99740,
8012056,R01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01DK081343-02S1,,NIDDK:99750;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,KANSAS CITY,UNITED STATES,PHARMACOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"GUO, GRACE L;",8254122;,3R01DK081343,02/01/2010,01/31/2011,"ATP-protein phosphotransferase; Acids, Bile; Animal Model; Animal Models and Related Studies; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoregulation; Bile; Bile Acid Biosynthesis; Bile Acid Biosynthesis Pathway; Bile Acids; Bile Duct Obstruction; Bile Juice; Bile fluid; Biliary; Biliary Stasis; Biosynthetic Proteins; Blood; Body Tissues; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholestasis; Cholesterol; Congenic Mice; DNA Synthesis Factor; Data; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; EC 2.7; ECGF; Endothelial Cell Growth Factor; Enterocytes; Enzymes; FGF; FGFR4; FGFR4 gene; FGFR4[{..}] Fibroblast Growth Factor Receptor 4 Gene; Fatty Liver; Feedback; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Functional disorder; Future; Gallbladder Calculus; Gallbladder Stone; Gallstones; Gene Expression; GeneHomolog; Generalized Growth; Genes; Genetic; Goals; Growth; HBGF; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Homeostasis; Homolog; Homologous Gene; Homologue; Hydroxylases; In Vitro; Intestinal; Intestines; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; JTK2 Gene; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Kinases; Knockout Mice; Ligands; Light; Lipids; Liver; Liver Cells; Liver Steatosis; Liver diseases; Liver neoplasms; Lymph; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Mammals, Mice; Mediating; Mesenteric; Mesentery; Methods and Techniques; Methods, Other; Mice; Mice, Congenic; Mice, Knock-out; Mice, Knockout; Minor; Mixed Function Oxidases; Mixed Function Oxygenases; Molecular; Monooxygenases; Murine; Mus; NR0B2 protein; Neoplasms, Hepatic; Nuclear Receptors; Null Mouse; PRKM8; Pathway interactions; Phosphotransferases; Photoradiation; Physiological Homeostasis; Physiopathology; Prevention; Protein Kinase; Proteins; Receptor Activation; Receptor Gene; Receptor Protein; Recombinant Proteins; Regulation; Research; Reticuloendothelial System, Blood; Reticuloendothelial System, Lymph; Role; Route; SAPK1; SHP protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Subcellular Process; TKF Gene; Techniques; Testing; Tissue Growth; Tissues; Transphosphorylases; Travel; Triacylglycerol; Triglycerides; Work; atheromatosis; atherosclerotic vascular disease; base; bile acid anabolism; bile acid biosynthetic process; bile acid formation; bile acid synthesis; bile obstruction; bile occlusion; biological signal transduction; body system, hepatic; bowel; c jun; c-jun Gene; cardiovascular disorder; cholelith; congenic; design; designing; disease/disorder; extracellular; gene product; glucose metabolism; glycogen synthase a kinase; hepatic neoplasia; hepatic neoplasm; hepatic steatosis; hepatopathy; human disease; hydroxyalkyl protein kinase; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; lipid disorder; liver disorder; liver tumor; lymphatic fluid; model organism; mouse model; ontogeny; organ system, hepatic; pathophysiology; pathway; phosphorylase b kinase kinase; prevent; preventing; public health relevance; receptor; response; small heterodimer partner; small heterodimer partner protein; social role",Tissue specific mechanism of FXR in suppressing bile-acid synthesis,,81343,HBPP,Hepatobiliary Pathophysiology Study Section,S1,2,99750,
7992526,R01,DK,3,Y,01/01/2010,03/31/2010,PA-07-070,3R01DK081418-02S1,,NIDDK:79028;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"PUIGSERVER, PERE ;",7946127;,3R01DK081418,01/01/2010,03/31/2010,"Acetylation; Amino Acids; Applications Grants; Autoregulation; Binding; Binding (Molecular Function); Biochemical; Biochemical Process; Biochemical Reaction; Bioenergetic; Bioenergetics; Birds of Prey; Body Tissues; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Complex; Defect; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Energy Expenditure; Energy Metabolism; Enzymatic Reaction; Gene Expression; Gene Transcription; Genes; Genetic; Genetic Transcription; Genetic analyses; Goals; Grant; Grant Proposals; Grants, Applications; Homeostasis; Hormonal; Insulin Resistance; Intracellular Communication and Signaling; Investigation; Laboratories; Lipids; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Mice; Mitochondria; Molecular; Molecular Interaction; Murine; Mus; Muscle, Skeletal; Muscle, Voluntary; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nucleus; Nutrient; Obesity; Oxidative Stress; Pathway interactions; Peroxisome Proliferators; Phosphorylation; Physiologic; Physiological; Physiological Homeostasis; Polycomb; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RAFT-1 gene product; RNA Expression; Rapamune; Rapamycin; Raptors; Reaction; Receptor Protein; Regulation; Respiration; Risk Factors; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Skeletal Muscle Tissue; Skeletal muscle structure; Stimulus; Subcellular Process; T2D; T2DM; Testing; Thesaurismosis; Tissues; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Translating; Translatings; Type 2 diabetes; Type II diabetes; Yin-Yang; adiposity; adult onset diabetes; aminoacid; base; biological signal transduction; cell growth; corpulence; corpulency; corpulentia; diabetes; disease/disorder; energy balance; experiment; experimental research; experimental study; gene product; genetic analysis; in vivo; inhibitor; inhibitor/antagonist; insulin resistant; ketosis resistant diabetes; language translation; loss of function; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); maturity onset diabetes; metabolism disorder; mitochondrial; mitochondrial dysfunction; mouse model; mutant; obese; obese people; obese person; obese population; oxidation; pathway; public health relevance; receptor; research study; respiratory mechanism; response; sensor; transcription factor",Control of Mitochondrial Bioenergetic Function through the mTOR Pathway,,81418,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,2,79028,
7991690,R01,DK,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01DK081420-02S1,,NIDDK:79326;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"SCHLONDORFF, DETLEF OLAF;",9219571;,3R01DK081420,01/07/2010,12/31/2010,"A Mouse; Adoptive Transfer; Adriablastin; Adriablastine; Adriacin; Adriamycin PFS; Adriamycin RDS; Adriblastin; Adriblastina; Adriblastine; Adrimedac; Atrophic; Atrophy; Bgn protein; Biopsy; Blood capillaries; Blood leukocyte; Blood monocyte; Body Tissues; Bone Marrow; C-C CKR-1 Gene; C-C CKR-5 Gene; C-C Chemokine Receptor Type 1 Gene; C-C Chemokine Receptor Type 5 Gene; CC-CKR-1 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCR-1 Gene; CCR-5 Gene; CCR1; CCR1 gene; CCR5; CCR5 gene; CD195 Antigen Gene; CHEMR13 Gene; CKR-1 Gene; CKR-5 Gene; CKR5 Gene; CMKBR1 Gene; CMKBR5 Gene; CMKR1 Gene; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Capillaries; Capillary; Capillary, Unspecified; Cells; Chemokine (C-C) Receptor 5 Gene; Chronic; Collagen; Cytokines, Chemotactic; D2S201E; DOXO-CELL; Data; Disease; Disease Outcome; Disease Pathway; Disorder; Doxolem; Doxorubin; ESRD; End stage renal failure; End-Stage Kidney Disease; Epithelial Cells; Expression Profiling; Expression Signature; Extramembranous Glomerulopathy; FB22; Farmiblastina; Fibrosis; Future; Generations; Glomerular disease; Glomerulonephritis, Membranous; HIF 1; HIF-1 protein; HIF1; HIF1 protein; HIV-1 Fusion Co-Receptor Gene; HM145 Gene; HM89; HSY3RR; Homing; Homologous Chemotactic Cytokines; Hypoxia; Hypoxic; In Vitro; Infiltration; Injury; Intercrines; Isoforms; Kidney; Kidney Diseases; Kidney Failure; Kidney Insufficiency; Knock-out; Knockout; Knockout Mice; LAP3; LCR1; LD78 Receptor Gene; LESTR; Laboratories; Lesion; Leukocytes; Ligands; Liposomal Adriamycin; MIP-1Alpha-R Gene; MIP1aR Gene; Macrophage Inflammatory Protein-1 Alpha Receptor Gene; Mammals, Mice; Marrow leukocyte; Marrow monocyte; Mediator; Mediator of Activation; Mediator of activation protein; Membranous Glomerulonephritis; Membranous Glomerulonephropathy; Membranous Glomerulopathy; Mice; Mice, Knock-out; Mice, Knockout; Mind; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Myeloid Cells; NPY3R; NPYR; NPYRL; NPYY3R; Nephropathy; Nephropathy, Membranous; Nephrosis; Null Mouse; Outcome; Oxygen Deficiency; PG-S1; Patients; Pattern; Phenotype; Population; Process; Protein Isoforms; Public Health; Publishing; RANTES Receptor Gene; RANTES-R Gene; Receptor Activation; Receptor Protein; Regulation; Renal Disease; Renal Disease, End-Stage; Renal Failure; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Leukocytes; Role; Rubex; SIS cytokines; Secondary to; Site; System; System, LOINC Axis 4; TIL4; TLR protein; TLR2; TLR2 gene; Testing; Tissues; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Translating; Translatings; Tubular; Tubular formation; Urinary System, Kidney; White Blood Cells; White Cell; Work; adriamycin; biglycan; bone proteoglycan I; capillary; chemoattractant cytokine; chemokine; chemokine receptor; cytokine; design; designing; disease/disorder; experiment; experimental research; experimental study; human disease; hypoxia inducible factor 1; in vivo; in vivo Model; interstitial; intervention design; kidney disorder; language translation; macrophage; molecuar profile; molecular signature; monocyte; novel; proteoglycan I; proteoglycan S1; public health medicine (field); public health relevance; receptor; receptor expression; renal; renal disorder; research study; sensor; social role; therapy design; treatment design; white blood cell; white blood corpuscle",Modulators of Kidney Fibrosis,,81420,ZRG1,Special Emphasis Panel,S1,2,79326,
8005109,R01,DK,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01DK081699-01A1S1,,NIDDK:77500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,PEDIATRICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"ARCHER, DAVID R (contact);GUASCH, ANTONIO ;",2110196 (contact);6190546;,3R01DK081699,01/01/2010,12/31/2010,"0-11 years old; 21+ years old; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; AQP-CD; AQP2 protein; ATP phosphohydrolase; ATPase; Acids; Adenosine Triphosphatase; Adenosinetriphosphatase; Adolescent; Adolescent Youth; Adult; Affect; African American; Afro American; Afroamerican; After Care; After-Treatment; Aftercare; Age; Albumins; Albuminuria; Animal Model; Animal Models and Related Studies; Area; Birth; Black Populations; Black or African American; Blood; Blood Serum; Blood Vessels; Bone Marrow Transplant; Bone Marrow Transplantation; Bone-Derived Transforming Growth Factor; CREA; CTGF; Child; Child Youth; Childhood; Children (0-21); Clinic; Clinical; Clinical Management; Clinical Research; Clinical Study; Complication; Creatinine; Data; Dehydration; Detection; Development; Dextrans; Disease; Disease Progression; Disorder; Dysfunction; Excretory function; Experimental Water Deprivation; Extravasation; Flow, Renal Blood; Functional disorder; Gamma Globulin, 7S; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Globin; Glomerular Capillary; Glomerular Filtration Rate; Glomerular disease; Goals; Grafting, Bone Marrow; HSC transplantation; Hb SS disease; HbSS disease; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Hematopoietic Stem Cell Transplantation; Hemoglobin; Hemoglobin S; Hemoglobin S Disease; Hemoglobin SS; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hereditary Disease; Hispanic Americans; Histology; Human; Human, Adult; Human, Child; Human, General; Hydrogen Oxide; Hydroxycarbamid; Hydroxycarbamide; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; IgG; Immunoglobulin G; Individual; Injury; Kidney; Kidney Diseases; Kidney Failure; Kidney Glomerulus; Kidney Insufficiency; Kidney Medulla; Knowledge; Lead; Leakage; Lesion; Life; Malpighian Tuft; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Measures; Medullary Portion of the Kidney; Methods and Techniques; Methods, Other; Mice; Microalbuminuria; Milk Growth Factor; Modeling; Molecular; Molecular Disease; Murine; Mus; Mutation; Nephropathy; News; News (PT); News [Publication Type]; Parturition; Pathogenesis; Pathway interactions; Patients; Pb element; Permeability; Physiopathology; Plasma Proteins; Platelet Transforming Growth Factor; Population; Prevalence; Prevention; Progenitor Cell Transplantation; Proteins; Regulation; Renal Blood Flow; Renal Disease; Renal Failure; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal function; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Reporting; Reticuloendothelial System, Blood; SS, Hemoglobin; Serum; Severity of illness; Sickle Cell; Sickle Cell Anemia; Sickle Hemoglobin; Spanish Americans; Spillage; Stem Cell Transplantation; Stem cell transplant; Structure of medulla of kidney; TGF B; TGF-beta; TGFbeta; Techniques; Testing; Therapeutic; Therapeutic Intervention; Thymotaxin; Transforming Growth Factor beta; Transplantation; Tubular; Tubular formation; United States; Urea, hydroxy-; Urinary System, Kidney; Urinary System, Urine; Urine; Visceral Epithelial Cell; WCH-CD; Water; Water Deprivation; adult human (21+); aged; alpha(1)-microglycoprotein; alpha-1-microglobulin; aquaporin-2; aquaporin-CD; base; beta-2 Microglobulin; biomarker; black American; body water dehydration; children; cohort; collecting duct urea transporter; connective tissue growth factor; design; designing; dextran; disease prevention; disease severity; disease/disorder; disorder prevention; drepanocyte; excretion; fetal; fisp12 protein; gene product; genetic disorder; genome mutation; glomerular visceral epithelial cell; heavy metal Pb; heavy metal lead; hemodynamics; hereditary disorder; human disease; hydroxyurea; improved; insulin-like growth factor binding protein 8; intervention therapy; juvenile; juvenile human; kidney disorder; kidney function; kidney medulla; model organism; mouse model; news; p-Globin; pathophysiology; pathway; pediatric; peripheral blood; podocyte; prevent; preventing; protein HC; public health relevance; renal; renal disorder; renal glomerulus; renal medulla; repair; repaired; response; restoration; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; sickling; solute; transplant; treatment effect; urea transporter; urinary; vascular; water channel of collecting duct; youngster",The Pathogenesis of Sickle Cell Nephropathy," Project Narrative: Sickle cell disease is one of the most common genetic diseases and affects ~100,000 individuals in the United States occurring in ~1:400 African-American and ~ 1:1200 Hispanic-American births each year. Kidney damage occurs early in life and worsens through adulthood with approximately 80% of patients over 40 years having renal disease. Even though sickle nephropathy is one of the most prevalent and potentially dangerous complications of sickle cell disease the mechanisms underlying its development are poorly understood and will thus be the focus of this proposal. Our goal is to find news treatment for this potentially devastating condition.",81699,PBKD,Pathobiology of Kidney Disease Study Section,A1S1,1,77500,
8003238,R01,DK,3,Y,01/15/2010,12/31/2010,PA-07-016,3R01DK081750-01A1S1,,NIDDK:192940;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TEMPE,UNITED STATES,BIOLOGY,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"YI, ZHENGPING ;",8755365;,3R01DK081750,01/15/2010,12/31/2010,"1-Phosphatidylinositol 3-Kinase; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Affect; Akt protein; Antibodies; Arts; Binding; Binding (Molecular Function); Biological Function; Biological Process; Biopsy; Blotting, Western; Cardiovascular Diseases; Co-Immunoprecipitations; Complex; Comprehension; Defect; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Gene Expression; Generations; Glycogen; Goals; Human; Human, General; Humulin R; IRS-1 protein; IRS1; Individual; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor Substrate 1; Insulin Resistance; Insulin Signaling Pathway; Insulin, Regular; Investigation; Laboratories; Lead; MODY; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Maturity-Onset Diabetes Mellitus; Methods; Microarray Analysis; Microarray-Based Analysis; Mitogenesis; Molecular; Molecular Interaction; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Outcome; PDK1; PDPK1; PDPK1 gene; PI-3 Kinase; PI-3K; PI3-Kinase; PKB protein; PRO0461; Pathway interactions; Pattern; Pb element; Peptide Biosynthesis, Ribosomal; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Site; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Positive Control of Cell Proliferation; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prevention; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase B; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Synthesis, Ribosomal; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; Proto-Oncogene Proteins c-akt; PtdIns 3-Kinase; RAC-PK protein; Relative; Relative (related person); Research; Signal Pathway; Signaling Protein; Skeletal Muscle Tissue; Skeletal muscle structure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stable Isotope Labeling; Stimulation of Cell Proliferation; T2D; T2DM; Technology; Testing; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; United States; Western Blotting; Western Blottings; Western Immunoblotting; Work; adiposity; adult onset diabetes; analog; base; c-akt protein; cardiovascular disorder; corpulence; corpulency; corpulentia; diabetic; disease/disorder; experiment; experimental research; experimental study; gene product; glucose transport; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; insulin receptor substrate 1 protein; insulin resistant; insulin signaling; interest; ketosis resistant diabetes; maturity onset diabetes; microarray technology; non-diabetic; nondiabetic; novel; obese; obese people; obese person; obese population; pathway; protein blotting; protein complex; protein protein interaction; protein synthesis; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; related to A and C-protein; research study; tandem mass spectrometry; tool; volunteer",Human Skeletal Muscle Proteome and Phosphoproteome in Obesity and Type 2 Diabetes," We propose to utilize innovative mass spectrometry based proteomic technology to study differences in protein-protein interactions and protein phosphorylation in the insulin signaling pathway in skeletal muscle from lean healthy, obese nondiabetic and type 2 diabetic volunteers. The overall goal of our research is to identify molecular mechanisms responsible for insulin resistance in human skeletal muscle and to provide novel targets for prevention and treatment of type 2 diabetes.",81750,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,A1S1,1,192940,
8011271,R01,DK,3,Y,01/15/2010,01/14/2011,PA-07-070,3R01DK081858-02S1,,NIDDK:49999;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"DUDEJA, PRADEEP K;",7956828;,3R01DK081858,01/15/2010,01/14/2011,"APPBP2; APPBP2 gene; Absorption; Acute; Address; Administration, Oral; Anions; Apical; Autoregulation; Bacteria; CLD; Caco-2 Cells; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chloride; Chloride Ion; Chlorides; Cl- element; Clinical Trials; Clinical Trials, Unspecified; Colon; Coupling; DRA; Data; Diarrhea; Disease; Disorder; Dose; Drug Administration, Oral; Dysfunction; E coli; EPEC; Electrolytes; Epithelial Cells; Escherichia coli; Escherichia coli Infections; Event; Experimental Models; Experimental Models, Other; Functional disorder; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Goals; Health; Health Benefit; Homeostasis; Human; Human, General; Hydrogen Oxide; Immunomodulation; Impairment; In Vitro; Infection; Infections, E coli; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intestinal; Intestines; Intracellular Communication and Signaling; Investigation; Ions; Isoforms; Kinetic; Kinetics; L. acidophilus; L. casei; L.acidophilus; L.casei; Lactobacillus; Lactobacillus acidophilus; Lactobacillus casei; Liquid substance; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Microorganisms, General; Modeling; Models, Experimental; Molecular; Murine; Mus; Oral Administration; PAT1; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Pouch Ileitis; Pouchitis; Prevention strategy; Preventive strategy; Probiotics; Process; Process of absorption; Protein Isoforms; RNA, Small Interfering; Regulation; Role; SLC26A3; SLC26A3 gene; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Small Interfering RNA; Sodium Chloride; Sodium Dextran Sulfate; Sodium chloride (NaCl); Therapeutic; Time; Water; Water Movements; absorption; biological signal transduction; bowel; clinical investigation; cultured cell line; design; designing; disease/disorder; enteric pathogen; enteropathogenic E. coli; enteropathogenic E.coli; enteropathogenic Escherichia coli; fluid; gastrointestinal; gastrointestinal disorder; ileum; immune modulation; immunologic reactivity control; immunoregulation; in vivo; in vivo Model; insight; intraoral drug delivery; liquid; microorganism; monolayer; mouse model; novel; pathogen; pathophysiology; public health relevance; response; salt; siRNA; social role; trafficking",Probiotics:Potential Therapeutic Roles in Diarrhea,,81858,ZRG1,Special Emphasis Panel,S1,2,49999,
8003828,R01,DK,3,Y,02/01/2010,04/30/2010,PA-07-070,3R01DK082582-01S1,,NIDDK:51061;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ITHACA,UNITED STATES,NUTRITION,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"QI, LING ;",9339877;,3R01DK082582,02/01/2010,04/30/2010,"ACRP30 protein; Adipocytes; Adipose Cell; Adipose tissue; Antidiabetic Hormone; Arts; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attention; Biochemical; Bone Marrow Transplant; Bone Marrow Transplantation; CRE Binding Protein; CREB; CREB Protein; CREB1; CREB1 gene; Calcineurin; Cancers; Cell Communication and Signaling; Cell Signaling; Chronic; Chronic Disease; Chronic Illness; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Cytosol; Data; Dephosphorylation; Development; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; EC 2.7; Event; Fat Cells; Fatty Tissue; Functional disorder; Future; GCG; Glucagon; Glucagon (1-29); Glukagon; Goals; Grafting, Bone Marrow; HG-Factor; Health; Hepatic Disorder; Human; Human, General; Humulin R; Hyperglycemic-Glycogenolytic Factor; INFLM; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinases; Link; Lipocytes; Liver diseases; Macrophage Activation; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mature Lipocyte; Mature fat cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Methods; Mice; Mice, Transgenic; Modeling; Molecular; Murine; Mus; NAFLD; NASH; Non-alcoholic steatohepatitis; Novolin R; Nuclear; Obesity; PP2B; Pathway interactions; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Physiopathology; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dephosphorylation; Protein Phosphatase-2B; Protein Phosphorylation; Proteins; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic; Thesaurismosis; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transducers; Transgenic Mice; Transphosphorylases; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adipose; adiposity; apM-1 protein; apM1 (adipose-specific) protein; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; chronic disease/disorder; chronic disorder; cofactor; corpulence; corpulency; corpulentia; cytokine; diabetes; diabetic patient; disease/disorder; gene product; glucose tolerance; hepatic gluconeogenesis; hepatopathy; insulin resistant; insulin sensitivity; interventional strategy; liver disorder; loss of function; macrophage; malignancy; metabolism disorder; mouse model; mutant; neoplasm/cancer; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; pathophysiology; pathway; public health relevance; resistin; response; social role; upstream kinase; white adipose tissue; yellow adipose tissue",Adipokine Signaling in Macrophages,,82582,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,1,51061,
8016226,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000073-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,NASHVILLE,UNITED STATES,,05,172636268,US,TN,37243,TENNESSEE STATE DEPARTMENT OF HEALTH,"CARPENTER, L. RAND;",9579146;,3R01EH000073,04/01/2005,06/30/2010,,Envirnomental Health Specialist Network,,73,ZEH1,Special Emphasis Panel,S1,5,75000,
8016252,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000075-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,PROVIDENCE,UNITED STATES,,01,929922664,US,RI,02908,RHODE ISLAND STATE DEPT OF HEALTH,"JULIAN, ERNEST MAURICE;",10074823;,3R01EH000075,04/01/2005,06/30/2010,,Reduction of Risk Factor Associated w/ Foodborne Illness,,75,ZEH1,Special Emphasis Panel,S1,5,35834,
8016266,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000076-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,HARTFORD,UNITED STATES,,01,807853791,US,CT,061061367,CONNECTICUT STATE DEPT OF PUBLIC HEALTH,"WEEKS, TRACEY L.;",10323515;,3R01EH000076,04/01/2005,06/30/2010,,Envirnomental Health Specialist Network,,76,ZEH1,Special Emphasis Panel,S1,5,37500,
8016283,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000080-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,CITY OF INDUSTRY,UNITED STATES,,38,082199324,US,CA,917463420,PUBLIC HEALTH FOUNDATION ENTERPRISES,"STRONG, SUSAN ELIZABETH;",8210722;,3R01EH000080,04/01/2005,06/30/2010,,California Envirnomental Health Specialist Network,,80,ZEH1,Special Emphasis Panel,S1,5,75000,
8016281,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000082-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,PORTLAND,UNITED STATES,,03,878144021,US,OR,97232,PUBLIC HEALTH SERVICES,"PIPPERT, ERIC ALLAN;",8210812;,3R01EH000082,04/01/2005,06/30/2010,,Envirnomental Health Specialist Network,,82,ZEH1,Special Emphasis Panel,S1,5,37500,
8016300,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000084-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,DES MOINES,UNITED STATES,,03,808345920,US,IA,50319,IOWA STATE DEPT OF PUBLIC HEALTH,"SHARP, KEN ;",10449459;,3R01EH000084,04/01/2005,06/30/2010,,Implementing EHS Net in Lowa,,84,ZEH1,Special Emphasis Panel,S1,5,37500,
8016322,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000085-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,ST. PAUL,UNITED STATES,,04,804887321,US,MN,551640975,MINNESOTA STATE DEPT OF HEALTH,"DANILA, RICHARD NORMAN;",8159714;,3R01EH000085,04/01/2005,06/30/2010,,Envirnomental Health Specialist Network,,85,ZEH1,Special Emphasis Panel,S1,5,75000,
8016327,R01,EH,3,,01/01/2009,06/30/2010,EH-05-013,3R01EH000086-05S1,,NCEH:;,2010,NATIONAL CENTER FOR ENVIRONMENTAL HEALTH,,MENANDS,UNITED STATES,,21,002436061,US,NY,122042719,NEW YORK STATE DEPT OF HEALTH,"MORSE, DALE L;",1894478;,3R01EH000086,04/01/2005,06/30/2010,,New York State Envirnomental Health Specialist Network,,86,ZEH1,Special Emphasis Panel,S1,5,75000,
8009250,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY000811-38S1,,NEI:126475;,2010,NATIONAL EYE INSTITUTE,,CAMBRIDGE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,082359691,US,MA,02138,HARVARD UNIVERSITY,"DOWLING, JOHN E;",1867580;,3R01EY000811,12/01/1976,01/31/2011,"21+ years old; Adult; Affect; Animals; Biochemical; Biological Models; Brachydanio rerio; Cell/Tissue, Immunohistochemistry; Cells; Chemicals; Cone; Cones (Eye); Cones (Retina); DNA Alteration; DNA mutation; Danio rerio; Development; Disease; Disorder; Electron Microscopy; Electrons; Electrophysiology; Electrophysiology (science); Electroretinography; Eye; Eye Development; Eyeball; GFP; Gene Alteration; Gene Expression; Gene Mutation; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetics, in situ Hybridization; Genetics-Mutagenesis; Glaucoma; Grant; Green Fluorescent Proteins; Hereditary; Human, Adult; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Inherited; Intraocular Pressure; Investigators; Laboratories; Larva; Lazy Eyes; Light; Maps; Measures; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Microscopic; Model System; Modeling; Models, Biologic; Molecular Biology, Mutagenesis; Mutagenesis; Mutate; Mutation; Negative Beta Particle; Negatrons; Neurophysiology / Electrophysiology; Observational Study; Ocular Tension; Photoradiation; Photoreceptors, Cone; Physiologic Intraocular Pressure; Postdoc; Postdoctoral Fellow; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; RNA; RNA, Non-Polyadenylated; Research Associate; Research Design; Research Personnel; Researchers; Retina; Retinal; Retinal Cone; Ribonucleic Acid; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Sequence Alteration; Sight; Staining method; Stainings; Stains; Structure; Study Type; Techniques; Transgenic Organisms; Vision; Visual System; Visual system structure; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); behavior test; behavioral test; cell type; cone cell; disease/disorder; electroretinogram; eye morphogenesis; gangliocyte; ganglion cell; gene cloning; genome mutation; glaucomatous; graduate student; horizontal cell; in situ Hybridization Staining Method; knock-down; lens; microarray technology; mutant; ocular development; post-doc; post-doctoral; programs; response; rod cell; study design; tool; transgenic",Anatomical and Biochemical Organization of the Retina,,811,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,38,126475,
8005880,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY004077-28S1,,NEI:215751;,2010,NATIONAL EYE INSTITUTE,,MINNEAPOLIS,UNITED STATES,NEUROSCIENCES,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"NEWMAN, ERIC A;",1897836;,3R01EY004077,07/01/1990,01/31/2011,"1H-Pyrrole-2,5-dione, 1-ethyl-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; ATP Hydrolysis; Acetylcholine; Adenosine; Agonist; Aminalon; Aminalone; Astrocytes; Astrocytus; Astroglia; Axon Terminals; Blood Coagulation Factor IV; Butanoic acid, 4-amino-; Ca++ element; Calcium; Cell Communication and Signaling; Cell Signaling; Cells; Coagulation Factor IV; Coloring Agents; Common Rat Strains; Confocal Microscopy; Coupled; Depressed mood; Diabetic Retinopathy; Dyes; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethylmaleimide; Factor IV; G-Protein Signaling Pathway; G-Proteins; GABA; GTP-Binding Proteins; GTP-Regulatory Proteins; Ganglion Cells (Retina); Glaucoma; Glia; Glial Cells; Glutamates; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; IRK1 channel; Intracellular Communication and Signaling; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; K+ Channels, Inwardly Rectifying; Knockout Mice; Knowledge; Kolliker's reticulum; L-Glutamate; L-Serine; Laboratories; Macular degeneration; Macular degenerative disease; Mammals, Mice; Mammals, Rats; Mediating; Metabotropic Glutamate Receptors; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Confocal; Monitor; Mononitrogen Monoxide; Muller's cell; Murine; Mus; N ethylmaleimide; N-Ethylmaleimide; N-Methyl-D-Aspartate Receptors; NEM; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-neuronal cell; Null Mouse; P2X; P2X-receptor; Pathology; Pathway interactions; Physiologic; Physiological; Potassium Channels, Inwardly Rectifying; Presynaptic Terminals; Property; Property, LOINC Axis 2; Rat; Rattus; Receptor Protein; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Regulation; Research; Retina; Retinal; Retinal Ganglion Cells; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway from G-Protein Families; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; Techniques; Testing; Transmission; biological signal transduction; channel blockers; depressed; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; extracellular; gamma-Aminobutyric Acid; gangliocyte; ganglion cell; glaucomatous; inward rectifier potassium channel; mGluR3; metabotropic glutamate receptor 3; nerve cement; neuronal; neurotransmitter release; pathway; postsynaptic; presynaptic; receptor; research study; response; retinal ganglion; sadness; tertiapin; transmission process; uptake; voltage clamp",Glial-Neuronal Interactions in the Retina,,4077,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,28,215751,
8004619,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY005665-25S1,,NEI:118804;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"ZIESKE, JAMES D;",1867550;,3R01EY005665,12/01/1984,01/31/2011,"Affect; Antibodies, Blocking; Area; Basement membrane; Blocking Antibodies; Body Tissues; Bone-Derived Transforming Growth Factor; Cell Communication and Signaling; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cellular Migration; Cellular Proliferation; Chimera; Chimera organism; Cicatrix; Clinical, Surgery, Laser; Common Rat Strains; Cornea; Corneal Injury; Data; Debridement; Disease; Disorder; EC 2.7; Epithelial; Epithelial Cell Proliferation; Epithelium; Epithelium, Anterior Corneal; Epithelium, Corneal; Exhibits; Extracellular Matrix, Integrins; Eye; Eyeball; Fibroblasts; Fibrosis; Funding; Generations; Goals; Grant; Healed; Human; Human, General; In Vitro; Injury; Integrins; Intracellular Communication and Signaling; Investigators; Kinases; Knockout Mice; Laser Surgery; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Milk Growth Factor; Modeling; Motility; Motility, Cellular; Murine; Mus; Myofibroblast; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Pathway interactions; Peptides; Phosphorylation; Phosphotransferases; Platelet Transforming Growth Factor; Play; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Phosphorylation; Public Health; Rat; Rattus; Receptor Protein; Regulation; Research Personnel; Researchers; Risk; Role; Scars; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stromal Cells; Structure of corneal epithelium; Surface; Surgical; Surgical Interventions; Surgical Procedure; TGF B; TGF-beta; TGFbeta; THBS1; TSP; TSP-1; TSP1; Testing; Thrombospondin 1; Tissues; Transforming Growth Factor beta; Transphosphorylases; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vision; Wound Healing; Wound Repair; aminoacid sequence of peptide; aminoacid sequence of protein; biological signal transduction; cell motility; conventional laser therapy; corneal; corneal epithelial; corneal epithelium; corneal wound; disease/disorder; healing; in vivo; inhibitor; inhibitor/antagonist; migration; pathway; peptide sequence; programs; protein aminoacid sequence; protein function; public health medicine (field); receptor; repair; repaired; response; social role; surgery; tissue repair; wound",Corneal Epithelial Proliferation and Repair,,5665,ZRG1,Special Emphasis Panel,S1,25,118804,
8004849,R01,EY,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01EY005690-29A1S1,,NEI:149143;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"BENOWITZ, LARRY IRA;",1892002;,3R01EY005690,08/15/1990,12/31/2010,"ATP-protein phosphotransferase; Acquired brain injury; Address; Affect; Affinity; Anatomic; Anatomical Sciences; Anatomy; Animals; Apoplexy; Area; Axon; Binding; Binding (Molecular Function); Binding Proteins; Biochemistry; Biological; Brain Injuries; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell Surface Receptors; Cell Survival; Cell Viability; Cells; Central Nervous System; Central Nervous System Part; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemistry, Biological; Cicatrix; Cranial Nerve II; Cranial Nerve II Injuries; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Development; Distal; Environment; Exhibits; Expression Library; Eye; Eyeball; GFAC; Ganglion Cells (Retina); Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Genes; Genetic Intervention; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; INFLM; Inflammation; Inflammatory; Injury; Intervention, Genetic; Intracellular Communication and Signaling; Knowledge; Lead; Ligand Binding Protein; Mediating; Methods; Molecular; Molecular Biology, Gene Therapy; Molecular Interaction; Myelin; Natural regeneration; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Optic Nerve; Optic Nerve Injuries; Optic Nerve Trauma; Optic Neuropathy, Traumatic; Outcome; Pathway interactions; Patients; Pb element; Play; Programs (PT); Programs [Publication Type]; Protein Kinase; Reaction; Receptor Protein; Receptors, Cell Surface; Regeneration; Research; Retinal Ganglion Cells; Role; Scars; Science of Anatomy; Screening procedure; Second Cranial Nerve; Second Cranial Nerve Injuries; Second Cranial Nerve Trauma; Sight; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Spinal cord damage; Stroke; System; System, LOINC Axis 4; Testing; Therapy, DNA; Time; Tissue Growth; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Vision; anatomy; axon growth; axon regeneration; axonal growth; axonal regeneration; base; biological signal transduction; brain attack; brain damage; brain lesion (from injury); cDNA Expression; cerebral vascular accident; degenerative condition; degenerative disease; extracellular; functional outcomes; functional restoration; gain of function; gene therapy; genetic therapy; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; improved; in vivo; inhibitor; inhibitor/antagonist; injured; insight; intervention development; loss of function; macrophage; neurodegenerative illness; neuronal; novel; oncomodulin; ontogeny; optic nerve regeneration; pathway; phosphorylase b kinase kinase; programs; public health relevance; receptor; regenerate; restore function; restore functionality; restore lost function; retinal ganglion; screening; screenings; social role; stroke; therapy development; transcription factor; traumatic brain damage; treatment development",Molecular Bases of Neuronal Connectivity," One reason that patients often fail to regain function after spinal cord damage and other types of brain injury is the inability of nerve cells to regenerate injured connections within the central nervous system (CNS). In one widely studied example of this, the projection neurons of the eye normally fail to regenerate their connections if the optic nerve is injured. Surprisingly, recent studies in animals show that if an inflammatory reaction is induced within the eye, the projection neurons of the eye switch into an active growth state and begin to regenerate lengthy axons through the optic nerve. The proposed studies will investigate the molecular mechanisms that underlie this phenomenon and develop therapies to improve outcome. Information gained from these studies is likely to be relevant to treating injury to the optic nerve and other parts of CNS.",5690,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,A1S1,29,149143,
7996304,R01,EY,3,Y,01/01/2010,12/31/2010,,3R01EY006044-23S1,,NEI:79000;,2010,NATIONAL EYE INSTITUTE,,LOS ANGELES,UNITED STATES,OPHTHALMOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BHAT, SURAJ P;",1897872;,3R01EY006044,01/01/1985,12/31/2010,"21+ years old; Adolescent; Adolescent Youth; Adult; Age; Alternate Splicing; Alternative Splicing; Antiheparin Factor; Appearance; Applications Grants; Assay; BACs (Chromosomes); Bacterial Artificial Chromosomes; Bioassay; Biologic Assays; Biological Assay; Blood Platelet Factor IV; Blood platelet factor 4; Cataloging; Catalogs; Cataract; Cells; Chemokine (C-X-C motif) Ligand 4; Childhood; Chromosomes; Circulatory Collapse; Common Rat Strains; Crystalline Lens; Crystallins; DISSEC; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; Deoxyribonucleic Acid; Development; Dissection; Dysfunction; Elements; Engineering; Engineerings; Factor 4; Figs; Figs - dietary; Functional disorder; Gene Expression; Gene Products, RNA; Gene Transfer Techniques; Genes; Genes, LacZ; Genes, Reporter; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic defect; Genotype; Grant Proposals; Grants, Applications; Heparin Neutralizing Protein; Human; Human, Adult; Human, General; In Vitro; Inherited Predisposition; Inherited Susceptibility; Investigation; Isoforms; Knockout Mice; LacZ; LacZ Genes; Len, Crystalline; Len, Eye; Lens; Lens Proteins; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Life; Link; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular; Murine; Mus; Mutate; Mutation; Null Mouse; Ocular Lens; Pattern; Phenotype; Physiologic; Physiological; Physiopathology; Platelet Factor 4; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Protein Motifs, DNA-Binding; Proteins; RNA; RNA Splicing; RNA Splicing, Alternative; RNA, Non-Polyadenylated; Rat; Rattus; Recombinant Platelet Factor 4; Regulation; Reporter; Reporter Genes; Reporting; Ribonucleic Acid; Role; Scheme; Senile Cataract; Shock; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Specific qualifier value; Specified; Splicing; Techniques; Time; Transcript; Transgenesis; Transgenic Mice; Transgenic Organisms; Work; adult human (21+); base; cataractogenesis; cataractous lenses; circulatory shock; early childhood; fetal; gamma-Thromboglobulin; gene product; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome mutation; heat shock transcription factor; immunoreactivity; in vivo; infancy; infantile; insight; juvenile; juvenile human; lens; molecular phenotype; mouse model; pathophysiology; pediatric; platelet factor IV; postnatal; response; social role; transcription factor; transgenic",Gene Expression in Normal and Cataractous Lens,,6044,ZRG1,Special Emphasis Panel,S1,23,79000,
8009069,R01,EY,3,Y,02/01/2010,08/31/2010,,3R01EY006391-25S1,,NEI:121557;,2010,NATIONAL EYE INSTITUTE,,STONY BROOK,UNITED STATES,PHYSIOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"MATHIAS, RICHARD T;",8550286;,3R01EY006391,07/01/1985,08/31/2010,"4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(+-)-; Affect; Age; Antioxidants; Aquaporins; Autoregulation; Blood Circulation; Blood Coagulation Factor IV; Bloodstream; Breeding; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Carrier Proteins; Cataract; Cavia; Cell membrane; Cells; Circulation; Coagulation Factor IV; Coloring Agents; Communicating Junction; Connexins; Coupling; Cytoplasmic Membrane; Cytoplasmic Protein; D-Glucose; Deterioration; Dextrose; Dyes; Electrical Impedance; Epithelial Cells; Epithelium; Esteroproteases; Factor IV; Fiber; Frequencies (time pattern); Frequency; Gap Junction Proteins; Gap Junctions; Glucose; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Guinea Pigs; H2O2; History; Homeostasis; Hydrogen Oxide; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Impedance; Injection of therapeutic agent; Injections; Ion Transport; Ions; Isoforms; Knock-out; Knockout; Lead; Lens Fiber; Liquid substance; Literature; Low-resistance Junction; Mammals, Guinea Pigs; Mammals, Mice; Measures; Mediating; Mefloquine; Membrane; Membrane Transport; Membrane Transport Proteins; Membrane Transporters; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Movement; Murine; Mus; Nexus; Nexus Junction; Nuclear; Nutrient; Pattern; Pb element; Peptidases; Peptide Hydrolases; Permeability; Phenotype; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Proteases; Protein Cleavage; Protein Family; Protein Isoforms; Proteinases; Proteolysis; Proteolytic Enzymes; Pump; Recording of previous events; Regulation; Role; Senile Cataract; Spatial Distribution; Suggestion; System; System, LOINC Axis 4; Techniques; Testing; Transgenic Mice; Transmembrane Transport; Transport Proteins; Transporter Protein; VESCL; Vesicle; Water; Water Channel Proteins; Work; age dependent; age related; anti-oxidant; ascorbate; body movement; cataractogenesis; cataractous lenses; electric impedance; extracellular; fiber cell; fluid; gap junction channel; glutathione peroxidase; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; lens; lens transparency; liquid; membrane structure; oxidation; oxidative damage; patch clamp; plasmalemma; processing speed; social role; solute; water channel; water transporter",VOLUME REGULATION IN NORMAL AND CATARACTOUS LENSES,,6391,ZRG1,Special Emphasis Panel,S1,25,121557,
8009120,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY007883-21S1,,NEI:99471;,2010,NATIONAL EYE INSTITUTE,,GAINESVILLE,UNITED STATES,ANATOMY/CELL BIOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"SUGRUE, STEPHEN P;",1941427;,3R01EY007883,12/01/1988,01/31/2011,"Accounting; Adhesions; Adhesives; Affect; Amines; Anterior; Binding; Binding (Molecular Function); Body Tissues; CAM 120/80; Cadherin-1; Cell Adhesion; Cell Components; Cell Structure; Cell-Cell Adhesion; Cells; Cellular Adhesion; Cellular Structures; Classification; Complex; Cornea; Data; Development; Disease; Disorder; E-Cadherin; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial Cells; Epithelial-Cadherin; Epithelium; Epithelium, Anterior Corneal; Epithelium, Corneal; Eye; Eyeball; Gene Down-Regulation; Gene Expression; Generations; Goals; HeLa; Hela Cells; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Knock-out; Knockout; Knockout Mice; Learning; Liquid substance; Maintenance; Maintenances; Mammals, Mice; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Modification; Molecular; Molecular Interaction; Murine; Mus; Nuclear; Null Mouse; Pathway interactions; Phenotype; Pressure; Pressure- physical agent; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteomics; RNA, Messenger; Regulation; Role; Sight; Snails; Stratified Squamous Epithelium; Structure of corneal epithelium; Systematics; Tissues; Transcription Corepressor; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Uvomorulin; Vision; corneal; corneal epithelial; corneal epithelium; disease/disorder; fluid; gene product; gene repression; in vivo; knock-down; liquid; mRNA; pathogen; pathway; pressure; social role",Epithelial Adhesion Interactions In The Cornea,,7883,ZRG1,Special Emphasis Panel,S1,21,99471,
7996290,R01,EY,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01EY010217-16A1S1,,NEI:206532;,2010,NATIONAL EYE INSTITUTE,,SAN FRANCISCO,UNITED STATES,OPHTHALMOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"HORTON, JONATHAN C;",1867496;,3R01EY010217,07/01/1993,12/31/2010,"0-11 years old; 0-6 weeks old; Affect; Amblyopia; Area striata; Area striata structure; Back; Behavior; Binocular Vision; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Child; Child Youth; Children (0-21); Color; Cortex, Striate; Cranial Nerves; Cross-Eye; Cytochrome Oxidase; Cytochrome-c Oxidase (Complex IV); Data; Defect; Depth Perception; Development; Diplopia; Disease; Disorder; Dorsum; Double Vision; Electrodes, Miniaturized; Electron Transport Complex IV; Encephalon; Encephalons; Enzymes; Esodeviation; Esotropia; Event; Exhibits; Exodeviation; Exotropia; Eye; Eye diseases; Eyeball; FLR; Failure (biologic function); Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Fovea; Fovea Centralis; Goals; Grant; Human; Human, Child; Human, General; Image; Infant, Newborn; Intermediary Metabolism; Intracellular Communication and Signaling; Laboratories; Lead; Learning; Life; Location; METBL; Macaca; Macaque; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Mediating; Metabolic; Metabolic Processes; Metabolism; Methods; Microelectrodes; Mitochondria; Muscle Tonus; Nervous; Nervous System, Brain; Newborn Infant; Newborns; Ocular dominance columns; Patients; Pattern; Pb element; Phorias; Play; Population; Primary visual cortex; Primates; R01 Mechanism; R01 Program; RPG; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rest; Retina; Role; Scotoma; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Squint; Staining method; Stainings; Stains; Stereopsis; Stereoscopic Vision; Strabismus; Strabismus, Convergent; Strabismus, Divergent; Strabismus, Internal; Stream; Striate area; Structure of fovea centralis; Testing; Vision; Vision, Binocular; Visual; Visual Cortex; Visual Field Disorder; Visual Fields; Visual Pathways; Visual System; Visual field scotoma; Visual system structure; area striata; awake; base; biological signal transduction; children; cohort; cost; cytochrome c oxidase; disease/disorder; experience; experiment; experimental research; experimental study; eye disorder; failure; fovea centralis; fovea centralis retinae; heavy metal Pb; heavy metal lead; human subject; imaging; infancy; infantile; mitochondrial; monocular; muscle tone; neural; neural mechanism; neuromechanism; newborn human (0-6 weeks); non-human primate; nonhuman primate; ocular motor; ocularmotor; oculomotor; ophthalmopathy; prevent; preventing; public health relevance; relating to nervous system; research study; response; retinotopic; social role; stereoscopic; visual cortical; visual depth perception; visual field defect; visual map; visual motor; visual stimulus; visuomotor; youngster",Structural Basis of Amblyopia and Strabismus, Project Narrative  This project will determine how children with strabismus avoid double vision by suppressing signals emanating from local regions of the retina in each eye. Elucidating the mechanism of visual suppression may lead to better methods to prevent and treat strabismus.,10217,CVP,Central Visual Processing Study Section,A1S1,16,206532,
8009206,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY010597-15S1,,NEI:280478;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"FULTON, ANNE B;",1969765;,3R01EY010597,03/01/1994,01/31/2011,"0-11 years old; 0-6 weeks old; 1 year old; Age; Amblyopia; Ametropias; Anisometropia; Arteries; Attention; Biology; Blood Vessels; Caliber; Cell Locomotion; Cell Migration; Cell Movement; Cellular Migration; Child; Child Youth; Children (0-21); Common Rat Strains; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Development; Diameter; Disease; Disease Frequency Surveys; Disorder; Dysfunction; Electrodes; Eye; Eyeball; Fovea; Fovea Centralis; Functional disorder; Future; Generalized Growth; Growth; History; Human, Child; Hypoxia; Hypoxic; Image; Infant; Infant, Newborn; Intensive Care; Investigators; Knowledge; Lead; Length; Mammals, Rats; Measurement; Measures; Mediating; Metabolic; Modeling; Motility; Motility, Cellular; Nervous; Newborn Infant; Newborns; Nurseries; O element; O2 element; Outcome; Oxygen; Oxygen Deficiency; Pb element; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Physiopathology; Probability; Procedures; Process; Rat; Rattus; Recording of previous events; Refractive Disorders; Refractive Errors; Research Personnel; Researchers; Retina; Retinal; Retinal Blood Vessels; Retinal Vessels; Retinopathy of Prematurity; Retrolental Fibroplasia; Retrolental Fibroplasias; Rhodopsin; Rod; Rod Outer Segment of the Retina; Rod Outer Segments; Rod Photoreceptors; Rods (Eye); Rods (Retina); Sampling; Side; Sight; Skin; Stimulus; Structure of blood vessel of retina; Structure of fovea centralis; Testing; Time; Tissue Growth; Update; Variant; Variation; Veins; Vision; Visual; Visual Purple; Visual Receptor; base; cell motility; children; cycloplegic; disease/disorder; disorder of macula of retina; early childhood; experiment; experimental research; experimental study; eye refraction disorder; fovea centralis; fovea centralis retinae; heavy metal Pb; heavy metal lead; high risk; imaging; infancy; infantile; insight; monocular; neural; newborn human (0-6 weeks); one year old; ontogeny; pathophysiology; premature retinopathy; relating to nervous system; research study; response; retina blood vessel structure; rod cell; rod outer segment; vascular; visual threshold; youngster",Photoreceptor Function in Retinopathy of Prematurity,,10597,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,15,280478,
8005868,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY010742-17S1,,NEI:150410;,2010,NATIONAL EYE INSTITUTE,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"CALLAWAY, EDWARD M;",1891944;,3R01EY010742,09/01/1995,06/30/2012,"Action Potentials; Address; Amblyopia; Animals; Anterior Quadrigeminal Body; Antibodies; Area; Area striata; Area striata structure; Axon; Axon Terminals; Body Tissues; Brain; Cell Body; Cell Nucleus; Cells; Cerebral cortex; Childhood; Code; Coding System; Coloring Agents; Complex; Cone; Cones (Eye); Cones (Retina); Corpora quadrigemina, superior colliculus; Cortex, Striate; Dendrites; Dorsal; Dyes; Dysfunction; Dyslexia; Encephalon; Encephalons; Eye; Eyeball; Functional disorder; GFP; Ganglion Cells (Retina); Genes; Genome; Glycoproteins; Goals; Green Fluorescent Proteins; Helper Viruses; Heterogeneity; Human; Human, General; Hydrophobia; In Vitro; Individual; Infection; Injection of therapeutic agent; Injections; Knowledge; Label; Laboratories; Link; Location; Macaca; Macaque; Mammals, Primates; Man (Taxonomy); Man, Modern; Mediating; Methods; Monkeys; Morphology; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nucleus; Ocular Physiology; Optic Tectum; Output; Pathway interactions; Phorias; Photoreceptors, Cone; Physiology of the Eye; Physiopathology; Presynaptic Terminals; Primary visual cortex; Primates; Principal Investigator; Process; Progress Reports; Property; Property, LOINC Axis 2; Publishing; Pulvinar; Pulvinar structure; Rabies; Rabies virus; Reports, Progress; Retina; Retinal; Retinal Cone; Retinal Ganglion Cells; Sight; Site; Slice; Source; Squint; Staining method; Stainings; Stains; Stains, Tissue; Stimulus; Strabismus; Striate area; Structure; Superior Colliculus; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; System; System, LOINC Axis 4; Tag; Tectums, Optic; Thalamic structure; Thalamus; Time; Tissue Stains; Tissues; Tracer; Travel; V1 neuron; Viral; Virus; Viruses, General; Vision; Visual; Visual Cortex; Visual Perception; Visual Physiology; Visual System; Visual system structure; Word Blindness; Work; area MT; area V5; area striata; base; cell body (neuron); cell type; computerized; cone cell; excitatory neuron; experiment; experimental research; experimental study; extracellular; extrastriate; in vivo; information processing; inhibitory neuron; koniocellular; lyssa; neural cell body; neural circuit; neural circuitry; neuron component; neuronal; neuronal cell body; novel; pathophysiology; pathway; pediatric; pulvinar thalami; receptive field; research study; response; retinal ganglion; soma; spatiotemporal; superior colliculus Corpora quadrigemina; thalamic; tool; visual cortical; visual information; visual process; visual processing; visual stimulus; visual tectum",Neural Circuits and Function in Primary Visual Cortex,,10742,CVP,Central Visual Processing Study Section,S1,17,150410,
8000252,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY011307-14S1,,NEI:79173;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,OPHTHALMOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"SUNG, CHING-HWA ;",1969657;,3R01EY011307,01/31/1996,01/31/2011,"1-Phosphatidylinositol 3-Kinase; 21+ years old; ATGN; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Achievement; Achievement Attainment; Address; Adenosine Triphosphatase, Dynein; Adult; Affect; Antigenic Determinants; Antigens; Apical; Belief; Binding; Binding (Molecular Function); Binding Determinants; Biogenesis; Biological Models; Biological Preservation; C-terminal; CURL; Canine Species; Canis familiaris; Causality; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cells; Cellular Migration; Cellular biology; Code; Coding System; Compartment of the Uncoupling Receptors and Ligands; Complex; Cytoplasmic Membrane; Dogs; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; EC 2.7; Early Endosome; Ectopic Expression; Endocytosis; Endosomes; Epithelial Cells; Epitopes; Etiology; Future; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Golgi; Golgi Apparatus; Golgi Complex; Grant; Hereditary Disease; Hot Spot; Hot Spots (Area of Increased Mortality); Human, Adult; Intracellular Communication and Signaling; Investigators; Kinases; Light; Lipids; Locomotor Activity; MDCK cell; Madin Darby canine kidney cell; Maintenance; Maintenances; Mammals, Dogs; Mammals, Rodents; Mediating; Membrane; Membrane Fusion; Membrane Protein Traffic; Membrane Proteins; Membrane Traffic; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Micro-tubule; Microscopic; Microtubules; Model System; Modeling; Models, Biologic; Molecular; Molecular Disease; Molecular Interaction; Morphogenesis; Morphology; Mothers Against Decapentaplegic Homolog; Motility; Motility, Cellular; Motor Activity; Movement; Mutation; NSF attachment protein receptor; Origin of Life; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Peripheral; Phenotype; Phosphates; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphotransferases; Photoradiation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Physiologic; Physiological; Pigmentary Retinopathy; Plasma Membrane; Play; Preservation, Biologic; Preservation, Biological; Procedures; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Protein Trafficking; Proteins; PtdIns 3-Kinase; Receptor Activation; Receptosomes; Research Personnel; Researchers; Retina; Retinal Diseases; Retinal Disorder; Retinal Pigments; Retinitis Pigmentosa; Rhodopsin; Rod; Rod Outer Segment of the Retina; Rod Outer Segments; Rod Photoreceptors; Rod-Cone Dystrophy; Rodent; Rodentia; Rodentias; Rods (Eye); Rods (Retina); Role; SNAP receptor; SNARE; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sma- and Mad-Related Proteins; Smad Proteins; Smad protein; Structure; Surface; Surface Proteins; System; System, LOINC Axis 4; Tail; Tapetoretinal Degeneration; Techniques; Testing; Traffickings, Protein; Transfection; Transphosphorylases; Transport Vesicles; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; VESCL; Vesicle; Vision research; Visual; Visual Pigments; Visual Purple; Visual Receptor; adult human (21+); base; biological signal transduction; body movement; canine; cell biology; cell motility; cost; disc (rod outer segment); disease causation; disease etiology; disease/disorder etiology; disorder etiology; domestic dog; dynein ATP phosphohydrolase (tubulin translocating); experiment; experimental research; experimental study; flexibility; gain of function; gene product; genetic disorder; genome mutation; hereditary disorder; immunogen; in vivo; inorganic phosphate; insight; interest; kidney epithelial cell; loss of function; membrane structure; mutant; novel; pathway; plasmalemma; polypeptide; preservation; programs; protein transport; research study; retina disease; retina disorder; retina photosensitive pigment; retinopathy; rod cell; rod outer segment; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; trafficking",Molecular Basis of Protein Transport in Photoreceptor,,11307,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,14,79173,
8005873,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY011542-14S1,,NEI:288687;,2010,NATIONAL EYE INSTITUTE,,MINNEAPOLIS,UNITED STATES,OPHTHALMOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"GREGERSON, DALE SANNES;",1887341;,3R01EY011542,08/01/1996,01/31/2011,"ACT2; AIM antigen; AIM molecule; APC; AT744.1; ATGN; Act-2; Address; Adventitial Cell; Affect; Antigen Targeting; Antigen-Presenting Cells; Antigens; Astrocytes; Astrocytus; Astroglia; Autoimmune Diseases; B220; Blood Circulation; Blood-Retinal Barrier; Bloodstream; Body Tissues; CCL4; CCL4 gene; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD45; CD69 antigen; CD8; CD8B; CD8B1; CD8B1 gene; CTL; Cell Function; Cell Process; Cell physiology; Cell-Mediated Lympholytic Cells; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cerebellum; Circulation; Closure by Ligation; Cross Presentation; Cultured Cells; Cytolytic T-Cell; Cytoplasmic Granules; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Drainage; Drainage procedure; Extravasation; Eye; Eyeball; GP180; Genes, Class I; Genes, Class II; Genes, HLA Class II; Genes, MHC Class I; Genes, MHC Class II; Health; Hortega cell; INFLM; Immune; Immune system; Immunologic Accessory Cells; Inflammation; Killings; LAG1; LCA; LY5; LYT3; Lead; Leakage; Leu-23 antigen; Ligation; Lymphatic; Lymphocyte; Lymphocytic; Lytotoxicity; MHC Class I; MHC Class I Genes; MHC Class II; MHC Class II Genes; MIP-1-beta; MIP1B; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Microglia; Monocytes / Macrophages / APC; Muller's cell; Murine; Mus; Myelogenous; Myeloid; Myeloid Cells; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; PTPRC; PTPRC gene; Pathogenesis; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Photoreceptor Cell; Photoreceptors; Photoreceptors, Retinal; Photosensitive Cell; Play; Population; Production; Rest; Retina; Retinal; Retinal Photoreceptors; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Role; Rouget Cells; SCYA4; Severity of illness; Site; Spillage; Structure; Subcellular Process; Supporting Cell; Surgical; Surgical Interventions; Surgical Procedure; T-Cells; T-Lymphocyte; T-Lymphocytes, Cytotoxic; T200; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Tissues; Transgenic Organisms; Visual Receptor; Work; accessory cell; activation antigen EA1; activation inducer molecule antigen; autoimmune disorder; base; beta-D-Galactosidase; beta-D-Galactoside galactohydrolase; beta-Galactosidase; body system, allergic/immunologic; cell killing; cytotoxic; cytotoxicity; disease severity; early activation antigen CD69; early activation antigen EA1; gitter cell; granule; granule cell; heavy metal Pb; heavy metal lead; helper T cell; immunogen; lac Z Protein; lymph cell; mesoglia; microglial cell; microgliocyte; neuronal; organ system, allergic/immunologic; p60, early T-cell activation antigen; perivascular glial cell; response; retinal neuron; rod cell; social role; surgery; thymus derived lymphocyte; transgenic; virtual",Significance of immunological sequestration in the eye,,11542,ZRG1,Special Emphasis Panel,S1,14,288687,
8009929,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY012601-11S1,,NEI:179338;,2010,NATIONAL EYE INSTITUTE,,GAINESVILLE,UNITED STATES,PHARMACOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"GRANT, MARIA BARTOLOMEO;",1897868;,3R01EY012601,09/30/1998,01/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 21+ years old; Acetylcholine; Actin Filaments; Actins; Acute; Adherence; Adherence (attribute); Adult; Advanced Glycosylation End Products; Adventitial Cell; Affect; Age; Animal Model; Animal Models and Related Studies; Animals; Area; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Arts; Assay; Athymic Nude Mouse; Bioassay; Bioavailability; Biochemical; Biologic Assays; Biologic Availability; Biological; Biological Assay; Biological Availability; Blindness; Blood Vessels; Blood capillaries; Blood flow; Bradykinin; Brain Hypoxia-Ischemia; CD31; CD34; CD34 gene; CXCL12 protein; Capillaries; Capillary; Capillary, Unspecified; Cell Attachment; Cell Communication and Signaling; Cell Death; Cell Locomotion; Cell Migration; Cell Migration Assay; Cell Movement; Cell Signaling; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Matrix; Cellular Migration; Chemokine (C-X-C Motif) Ligand 12; Chronic; Collagen IV; Collagen Type IV; Confocal Microscopy; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokine Receptors; Cytoskeletal System; Cytoskeleton; DNA Sequence Rearrangement; Data; Defect; Development; Diabetes Mellitus; Diabetic Retinopathy; Diabetic mouse; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dropout; Dysfunction; EC 1.14.13.39; EDRF Synthase; EPC-1 protein; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Environment; Epithelial; Equilibrium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Euler-Gaddum Substance P; Fluorescence Microscopy; Functional disorder; GFAC; Generations; Glycation End Products, Advanced; Glycosylation End Products, Advanced; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanylyl Cyclase-Activating Factor Synthase; HPCA1; Hematopoietic; Home; Home environment; Human; Human, Adult; Human, General; Hypoxia; Hypoxia-Ischemia, Brain; Hypoxic; Image; In Vitro; Individual; Injection of therapeutic agent; Injections; Injury; Intracellular Communication and Signaling; Investigators; Ischemia; Ischemia-Reperfusion Injury; Isoforms; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Lesion; Maintenance; Maintenances; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Methods and Techniques; Methods, Other; Mice, Athymic; Mice, Nude; Microfilaments; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Migration Assay; Modeling; Molecular; Molecular Motors; Mononitrogen Monoxide; Motility; Motility, Cellular; Motor; Mutate; Myofilaments; NADPH-Diaphorase; NO Synthase; Nature; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Signaling Pathway; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nude Mice; Oxygen Deficiency; PECAM1; PECAM1 gene; PEDF; PKG; Pathway interactions; Patients; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Phosphorylation Site; Physiologic Availability; Physiopathology; Pigments; Play; Population; Pre-B Cell Growth Stimulating Factor; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase G; Proteins; RT-PCR; RTPCR; Rearrangement; Receptors, Cytokine; Regulation; Reperfusion Damage; Reperfusion Injury; Research Personnel; Researchers; Retina; Retinal; Reverse Transcriptase Polymerase Chain Reaction; Rodent; Rodent Model; Rodentia; Rodentias; Role; Rouget Cells; SDF-1; SDF-1alpha; SP(1-11); STZ; Sdf1 protein; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Staining method; Stainings; Stains; Streptozocin; Streptozotocin; Stromal Cell-Derived Factor 1; Substance P; Techniques; Testing; Time; Transfection; Type IV (Basement Membrane) Collagen; VASP; VEGF Receptors; VEGFR; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vegf; Western World; Work; Zanosar; adult human (21+); advanced glycation endproduct; balance; balance function; base; bioavailability of drug; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; capillary; cell motility; cell type; diabetes; diabetic; diabetic patient; early PDL protein; early population doubling level cDNA-1 protein; early population doubling level protein; endothelial cell derived relaxing factor; fibronectin, glycosylated; gene product; glycated fibronectin; glycation; glycosylated fibronectin; guanosine 3'5' monophosphate; hIRH; heavy metal Pb; heavy metal lead; hypoxia ischemia; imaging; injured; intracellular skeleton; kallidin 9; kallidin I; matrigel; membrane structure; migration; model organism; mouse model of diabetes; necrocytosis; neurokinin 1; non-diabetic; nondiabetic; nonenzymatic glycosylation; novel; pathophysiology; pathway; pigment epithelium-derived factor; polymerization; precursor cell; programs; proliferative diabetic retinopathy; repair; repaired; response; retina ischemia; retinal ischemia; reverse transcriptase PCR; social role; stem; stromal cell-derived factor-1alpha; tool; vascular; vasodilator-stimulated phosphoprotein",Endothelial precursor dysfunction in development of diabetic acellular capillary,,12601,ZRG1,Special Emphasis Panel,S1,11,179338,
8005255,R01,EY,3,Y,01/01/2010,12/31/2010,,3R01EY012782-09S1,,NEI:240733;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"FRIEDLANDER, MICHAEL J;",1867555;,3R01EY012782,02/04/2000,12/31/2010,"Ammoniated Ruthenium Oxychloride; Area striata; Area striata structure; Attention; Blood Coagulation Factor IV; Ca Release Channel-Ryanodine Receptor; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Ion Signaling; Calcium Oscillations; Calcium Signaling; Calcium-Ryanodine Receptor Complex; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Cerebral cortex; Characteristics; Chemosensitization; Chemosensitization/Potentiation; Chronic; Coagulation Factor IV; Cognitive; Control Animal; Cortex, Striate; Coupled; Dendrites; Dendritic Spines; Depression; Development; Event; Experimental Models; Experimental Models, Other; FLR; Factor IV; Failure (biologic function); Fugu Toxin; Goals; History; Individual; Injury; Intracellular Communication and Signaling; Ion Channels, Calcium; Kinetic; Kinetics; Lead; Learning; Life; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Synaptic Depression; Measures; Mental Depression; Metabotropic Glutamate Receptors; Models, Experimental; Molecular; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nature; Neonatal; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Outcome; Output; Pattern; Pb element; Performance; Physiologic pulse; Population; Potentiation; Primary visual cortex; Process; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Pulse; Pyramidal neuron; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Receptors, Ryanodine; Recording of previous events; Regulation; Retinal; Role; Ruthenium Red; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Shapes; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Striate area; Surface; Synapses; Synaptic; Synaptic plasticity; TTX; Tarichatoxin; Tetradotoxin; Tetrodotoxin; Thapsigargin; Time; Transmission; V (voltage); VDCC; Vision; Visual; Visual Cortex; Visual Perception; Voltage-Dependent Calcium Channels; Waves, Calcium; XeC compound; area striata; base; biocytin; biological signal transduction; biotinyl L lysine; cell body (neuron); cell type; computerized data processing; conditioning; cyclopiazonic acid; cyclopyazonic acid; dark rear; dark rearing; data processing; dendrite spine; excitatory neuron; experience; experiment; experimental research; experimental study; failure; heavy metal Pb; heavy metal lead; hippocampal pyramidal neuron; long term depression; neocortical; neural cell body; neuronal; neuronal cell body; parallel computation; parallel computing; postnatal; postsynaptic; presynaptic; prevent; preventing; puffer fish toxin; receptor; research study; response; signal processing; skills; social role; soma; transmission process; vision development; visual cortical; visual development; visual process; visual processing; visual system development; voltage; xestospongin C",Development of Synaptic Plasticity in Visual Cortex,,12782,CVP,Central Visual Processing Study Section,S1,9,240733,
8003183,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY013256-09S1,,NEI:137515;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"MLODZIK, MAREK ;",6481188;,3R01EY013256,02/01/2001,01/31/2011,"21+ years old; Adult; Apoptosis; Apoptosis Pathway; Area; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Brain; Cancers; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Death, Programmed; Cell Polarity; Cell Signaling; Cells; Cellular Oncogene; Cytoplasmic Domain; Cytoplasmic Tail; Disease; Disorder; Drosophila; Drosophila eye; Drosophila genus; Dsh protein; Elements; Encephalon; Encephalons; Episkopi blindness; Event; Eye; Eye Development; Eye diseases; Eyeball; FZ-3 protein, human; FZD3 Protein; FZD3 protein, human; Family; Flies; Frizzled 3; Frizzled 3 Protein; Frizzled Cystein-Rich Domain; Frizzled Domain; Frizzled, Drosophila, Homolog of, 3; Fruit Fly, Drosophila; Fz Domain; Fz-3; GFAC; Generations; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, Adult; Human, General; Image; Intracellular Communication and Signaling; Ligands; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Medical; Membrane; Modeling; Modification; Molecular; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Norrie disease; Norrie disease (ND); Norrie syndrome; Norrie's disease; Norrie-Warburg syndrome; Notch Signaling Pathway; Nuclear; Outcome; Pathway interactions; Pattern; Phenotype; Phosphorylation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Position; Positioning Attribute; Process; Protein Phosphorylation; Proteins; Proteolysis and Signaling Pathway of Notch; Proto-Oncogenes; Receptor Protein; Recruitment Activity; Regulation; Retina; Retinal; Role; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stereotyping; Testing; Vision; Visual Receptor; Visual System; Visual system structure; adult human (21+); atrophia bulborum hereditaria; biological signal transduction; c-ONC; cell fate specification; cellular polarity; congenital progressive oculo-acoustico-cerebral degeneration; disease/disorder; dishevelled protein; experiment; experimental research; experimental study; eye disorder; eye morphogenesis; eye primordia; fly; frizzled 3 protein, human; frizzled homolog 3 (Drosophila), human; fruit fly; gene product; hFz3; human FZD3 protein; imaging; in vivo; malignancy; membrane structure; necrocytosis; neoplasm/cancer; neuronal; notch; notch protein; notch receptors; ocular development; ophthalmopathy; pathway; protooncogene; pseudoglioma congenita; receptor; recruit; research study; response; retinotopic; social role; stem cell biology; transcription factor",Ommatidial Patterning during Eye Development,,13256,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,9,137515,
8005266,R01,EY,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01EY013760-06S1,,NEI:206825;,2010,NATIONAL EYE INSTITUTE,,SALT LAKE CITY,UNITED STATES,OPHTHALMOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"LEVINE, EDWARD M;",1891991;,3R01EY013760,12/01/2001,12/31/2010,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 0-11 years old; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; Address; Adult; Agonist; Alleles; Allelomorphs; Animals; Anophthalmia; Anophthalmos; Assay; Automobile Driving; Bioassay; Biologic Assays; Biological Assay; Birth; Breeding; Cell Communication and Signaling; Cell Cycle Progression; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Characteristics; Child; Child Youth; Children (0-21); Complex; Critical Paths; Critical Pathways; Defect; Dependence; Development; Drivings, Automobile; Embryo; Embryonic; Environment; Erinaceidae; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Eye; Eye Development; Eyeball; FLR; Failure (biologic function); Gene Expression; Genes; Genes, Homeo Box; Genes, Homeobox; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Gx Protein; HOX gene; Hedgehog (Hh) signal transduction pathway; Hedgehogs; Homeo Domain; Homeobox Family Gene; Homeobox Genes; Homeodoamin Gene; Homeotic Genes; Human; Human, Adult; Human, Child; Human, General; Intracellular Communication and Signaling; Knock-out; Knockout; Laboratories; Ligands; MTGN; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measurement; Mediating; Membrane; Methods; Mice; Microphthalmos; Mitogens; Molecular; Mother Cells; Murine; Mus; Mutation; Nature; Neonatal; Neural Growth; Neural Retina; Neuronal Growth; Optic vesicle; Optics; Partial Sight; Parturition; Pathway interactions; Pattern; Phenotype; Preparation; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Reporting; Research; Retina; Retina Proper; Retinal; Retinal Diseases; Retinal Disorder; Role; SMO; SMO protein, human; SMOH; SMOH protein, human; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smoothened; Smoothened Homolog; Staging; Stem cells; Structure of optic cup; TAM; Tamoxifen; Time; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual impairment; Work; adult human (21+); base; biological signal transduction; blind; children; disability; driving; experiment; experimental research; experimental study; extracellular; eye formation; eye morphogenesis; failure; gene product; genome mutation; hedgehog signaling pathway; hh signaling pathway; homeodomain; human SMO protein; insight; malformation; membrane structure; microphthalmia; nanophthalmos; neuroepithelium; neurogenesis; null mutation; ocular development; optic cup; pathway; programs; public health relevance; recombinase; research study; restorative treatment; retina disease; retina disorder; retinal progenitor; retinal progenitor cell; retinal stem cell; retinopathy; smoothened homolog (Drosophila), human; smoothened signaling pathway; social role; transcription factor; visually impaired; youngster",Role of Chx10 in embryonic Retinal Progenitor Cells," Project Narrative: Microphthalmia is a congenital anomaly in which the eye fails to grow to its normal size. Ocular malformations, which include microphthalmia are reported to be as high as 1 in 5000 births and children born with these malformations are often severely visually impaired or blind. The goals of the research proposed here are to understand the basis for these defects with the hope of one day developing a restorative treatment or cure for these devastating disabilities.",13760,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,6,206825,
8009978,R01,EY,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01EY014454-06S1,,NEI:104383;,2010,NATIONAL EYE INSTITUTE,,ANN ARBOR,UNITED STATES,OPHTHALMOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"DEMB, JONATHAN B;",8011401;,3R01EY014454,12/01/2002,01/31/2011,"AMPA Receptors; Alpha Cell; Amacrine Cells; Amacrine Cells of Retina; Biological; Blindness; Body Tissues; Caliber; Cell Communication and Signaling; Cell Death; Cell Signaling; Cells; Cone; Cones (Eye); Cones (Retina); Connector Neuron; Data; Dependence; Development; Diameter; Eye diseases; Frequencies (time pattern); Frequency; Glaucoma; Glucagon Cell; Glucagon Secreting Cell; Glutamates; Goals; Inner Plexiform Layer; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Ischemia; Kinetic; Kinetics; L-Glutamate; Lead; Leber's disease; Ligands; Light; Location; Measures; Mediating; Modeling; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Neural Cell; Neural Pathways; Neurocyte; Neurons; Night Blindness; Nyctalopia; Output; Pathway interactions; Pb element; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Physiologic; Physiological; Process; Property; Property, LOINC Axis 2; Prosthesis; Prosthetic device; Prosthetics; Receptor Protein; Receptors, AMPA; Receptors, N-Methylaspartate; Retina; Retinal; Retinal Cone; Retinal Diseases; Retinal Disorder; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Rods and Cones; Role; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Stratification; Synapses; Synaptic; Testing; Tissues; Trees; V (voltage); Vertebrate Photoreceptors; Vision; Visual; Visual Receptor; base; biological signal transduction; cell type; cone cell; desensitization; excitotoxicity; eye disorder; gangliocyte; ganglion cell; glaucomatous; heavy metal Pb; heavy metal lead; information processing; necrocytosis; neural circuit; neural circuitry; neuronal; ophthalmopathy; pathway; presynaptic; public health relevance; receptor; response; retina disease; retina disorder; retinopathy; rod cell; social role; visual information; visual process; visual processing; voltage",Neural circuits and synapses for early visual processing," Narrative: Proposed studies will provide background for understanding the impact of eye diseases that impair night vision (i.e., retinitis pigmentosa, congenital stationary night blindness) and eye diseases that involve cell death caused by excitotoxicity (i.e., glaucoma, ischemia). Studies will lead to a better understanding of how the retina processes visual information, which could facilitate the development of prosthetic devices for stimulating preserved retinal cells in certain forms of blindness.",14454,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,6,104383,
8011241,R01,EY,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01EY014619-07S1,,NEI:182580;,2010,NATIONAL EYE INSTITUTE,,COLLEGE PARK,UNITED STATES,BIOLOGY,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"JEFFERY, WILLIAM R;",1886035;,3R01EY014619,08/01/2003,01/31/2011,"21+ years old; Adult; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; Award; Blindness; Body Tissues; Brain; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Cessation of life; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Cornea; Crystalline Lens; Crystallins; Data; Death; Defect; Detection; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Editorial Comment; Editorial Comment (PT); Embryo; Embryonic; Encephalon; Encephalons; Erinaceidae; Event; Eye; Eye Development; Eye Part; Eyeball; Fishes; Gene Expression; Generalized Growth; Genes; Genetic; Genetic analyses; Goals; Growth; Growth and Development; Growth and Development function; HSP; Heat shock proteins; Hedgehogs; Human, Adult; Image; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Knowledge; Len, Crystalline; Len, Eye; Lens; Lens Proteins; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Life; Link; Mediating; Messenger RNA; Methods; Molecular; Nervous System, Brain; Neural Crest Cell; Ocular Lens; Optics; Outer pigmented layer of retina; Pathway interactions; Pattern; Pigment cell layer of retina; Pigmented layer of retina; Process; Proteins; Published Comment; RNA, Messenger; Regulation; Research; Retina; Retinal; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Role; Sclera; Signal Transduction; Signal Transduction Systems; Signaling; Stress Proteins; Structure of optic cup; Structure of retinal pigment epithelium; Study models; Surface; Testing; Tissue Growth; Tissues; Transplantation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viewpoint; Viewpoint (PT); Visual; White of Eye; adult human (21+); biological signal transduction; blind; corneal; design; designing; eye morphogenesis; eye primordia; gain of function; gene product; genetic analysis; imaging; insight; lens; loss of function; mRNA; migration; molecular marker; morphogens; necrocytosis; ocular development; ontogeny; optic cup; overexpression; pathway; public health relevance; retina apoptosis; retinal apoptosis; social role; stem; teleost; teleost fish; teleostean fish; teleostfish; transplant",Regulation of Eye Growth and Development by the Lens,,14619,AED,Anterior Eye Disease Study Section,S1,7,182580,
7995566,R01,EY,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01EY015260-06A1S1,,NEI:77687;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,NEUROSCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GOLD, JOSHUA I;",1883233;,3R01EY015260,12/01/2003,01/31/2011,"Accounting; Afferent Neurons; Algorithms; Area; Associative Learning; Aves; Avian; Basal Ganglia; Basal Nuclei; Basic Research; Basic Science; Behavior; Behavioral; Birds; Brain; Candy; Caudate Nucleus; Caudate nucleus structure; Characteristics; Cognitive Discrimination; Computer Simulation; Computerized Models; Conditioning, Classical; Conditionings, Classical; Confection; Data; Decision Making; Diagnosis; Discrimination; Discrimination (Psychology); Disease; Disorder; Electrodes; Encephalon; Encephalons; Goals; Heterogeneity, Population; Human; Human, General; Image; Individual; Lateral; Learning; Link; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Monkeys; Motion; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurons, Afferent; Neurons, Sensory; Nucleus Caudatus; Outcome; Output; Pavlovian conditioning; Perceptual learning; Physiologic; Physiological; Physiology; Population; Population Heterogeneity; Process; Psychological reinforcement; Psychophysic; Psychophysics; Public Health; Punishment; Reinforcement; Reinforcement (Psychology); Research; Research Design; Rewards; Role; Scheme; Sensory; Sensory Cell Afferent Neuron; Shapes; Simulation, Computer based; Stimulus; Structure; Study Type; Techniques; Testing; Training; Visual; Visual Agnosias; Visual Motion; Visual Perception; Visual System; Visual system structure; Work; abstracting; base; behavior measurement; behavioral measure; behavioral measurement; brain shape; caudate nucleus; classical conditioning; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease/disorder; diverse populations; experience; experiment; experimental research; experimental study; heterogeneous population; human subject; imaging; improved; in silico; innovate; innovation; innovative; insight; lateral intraparietal area; neural; neural mechanism; neuromechanism; neuronal; novel; public health medicine (field); relating to nervous system; research study; response; reward processing; social role; study design; virtual simulation; visual information; visual learning; visual stimulus",Mechanisms of learning a visual discrimination," Project Narrative The proposed work is basic research, designed to provide new insights into how a healthy nervous system learns from experience to more effectively process visual information. Thus, direct benefits to public health are intended to come in the longer term, as these new insights can be used to design new ways to diagnose and treat disorders of visual perception (i.e., visual agnosias) and learning.",15260,CVP,Central Visual Processing Study Section,A1S1,6,77687,
8013370,R01,EY,3,,08/01/2009,07/31/2010,PA-07-070,3R01EY015290-06A1S1,,NEI:200885;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"MASON, CAROL A;",1883109;,3R01EY015290,12/01/2003,07/31/2012,"Address; Adhesion Molecule; Animals; Area; Axon; Binocular Vision; Brain; Candidate Disease Gene; Candidate Gene; Cell Adhesion Molecules; Central Nervous System; Chiasma; Chiasma Opticum; Code; Coding System; Contralateral; Defect; Depth Perception; Development; Dorsal; EPH Tyrosine Kinase 2; EPHT2 Protein; Ectopic Expression; Electroporation; Encephalon; Encephalons; EphB1 Protein; Ephrin Receptor EphB1; Ephrin Type-B Receptor 1; Eye; Eyeball; Funding; Ganglion Cells (Retina); Gaussian Distribution; Gene Delivery; Gene Expression; Genes; Genetic Models; Glia; Glial Cells; Grant; In Vitro; Ipsilateral; Kolliker's reticulum; Lateral Geniculate Body; Lead; Ligands; Mammals, Mice; Mediating; Methods; Mice; Models, Genetic; Molecular; Murine; Mus; Nasal; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neuroglia; Neuroglial Cells; Neuronally Expressed EPH-Related Tyrosine Kinase; Non-neuronal cell; Normal Distribution; Normal Statistical Distribution; Nose; Nose, Nasal Passages; Optic Chiasm; Optic Chiasma; Optic Chiasmas; Optic Decussation; Pathway interactions; Pattern; Pb element; Peripheral; Phenotype; Pigments; Principal Investigator; Programs (PT); Programs [Publication Type]; Radial; Receptor Protein; Receptor, EphB1; Research; Respiratory System, Nose, Nasal Passages; Retina; Retinal; Retinal Ganglion Cells; Role; Route; Semaphorins; Shapes; Side; Specific qualifier value; Specified; Staging; Stereopsis; Stereoscopic Vision; System; System, LOINC Axis 4; To specify; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tyrosine-Protein Kinase Receptor EPH-2; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vision, Binocular; Visual; Visual Acuity; Work; albino mouse; axon growth cone guidance; axon guidance; base; cell adhesion protein; gene function; heavy metal Pb; heavy metal lead; in utero; in vitro Assay; in vivo; innovate; innovation; innovative; lateral geniculate; lateral geniculate nucleus; meetings; mutant; nerve cement; pathway; programs; public health relevance; receptor; receptor expression; response; retinal axon; retinal ganglion; social role; transcription factor; visual depth perception",The Role of Zic Genes in Patterning the Binocular Projection," PROJECT NARRATIVE  This research aims to understand how retinal ganglion cells grow out from each eye, meet at the X-shaped optic chiasm, then diverge toward targets on both sides of the brain. Proper binocular vision is dependent on a normal distribution of retinal axons crossing at the optic chiasm, and if altered, reduced visual acuity and depth perception ensue. This work investigates the genes that pattern the retina into sectors giving rise to crossed and uncrossed projections and that drive expression of guidance receptors to enable retinal axons to take the appropriate route.",15290,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",A1S1,6,200885,
8009001,R01,EY,3,Y,02/01/2010,07/31/2010,,3R01EY015836-05S1,,NEI:187480;,2010,NATIONAL EYE INSTITUTE,,ROCHESTER,UNITED STATES,OPHTHALMOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"HUXLIN, KRYSTEL R;",7766346;,3R01EY015836,08/01/2004,07/31/2010,"Ablation; Affect; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Beds; Biological; Biology; Biomechanics; Body Tissues; Cats; Cellular biology; Clinical, Surgery, Laser; Coma; Comatose; Complication; Contracting Opportunities; Contracts; Cornea; Corneal Injury; Corneal Stroma; Corneal Transplantation; Development; Domestic Cats; Doppler OCT; Drug Administration, Topical; Electromagnetic, Laser; Epithelial; Epithelium; Epithelium, Anterior Corneal; Epithelium, Corneal; Event; Eye; Eyeball; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fixation; Goals; Grafting, Corneal; Healed; Histologic; Histologically; Histology; Human; Human, General; Hyperplasia; Hyperplastic; Image; In Situ; Investigation; Keratectomy, Laser; Keratoplasty; Knowledge; Laser Surgery; Lasers; Light; Mammals, Cats; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Myofibroblast; OCT Tomography; Operation; Operative Procedures; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Outcome; Pattern; Photokeratectomy; Photoradiation; Photorefractive Keratectomy; Physiologic; Physiological; Post-Operative; Postoperative; Postoperative Period; Procedures; Property; Property, LOINC Axis 2; Radiation, Laser; Reaction; Research; Retinal; Shapes; Sight; Spatial Distribution; Structure; Structure of corneal epithelium; Surgical; Surgical Interventions; Surgical Procedure; Testing; Therapeutic; Thick; Thickness; Time; Tissues; Tomography, Optical Coherence; Topical application; Training; Transplantation, Cornea; Vision; Wound Healing; Wound Repair; cell biology; conventional laser therapy; corneal; corneal epithelial; corneal epithelium; corneal keratoplasty; corneal transplant; corneal wound; experiment; experimental research; experimental study; healing; human subject; imaging; improved; in vivo; insight; instrument; keratomileusis; model organism; research study; response; sample fixation; surgery; tissue repair; topical administration; topical drug application; topically applied",Corneal wound healing: ocular optics after laser surgery,,15836,ZRG1,Special Emphasis Panel,S1,5,187480,
7996297,R01,EY,3,Y,01/01/2010,12/31/2010,,3R01EY016052-04S2,,NEI:153193;,2010,NATIONAL EYE INSTITUTE,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"TRACHTENBERG, JOSHUA ;",1977407;,3R01EY016052,03/01/2006,12/31/2010,"21+ years old; Adult; Amblyopia; Anatomic; Anatomical Sciences; Anatomy; Animals; Apical; Apoplexy; Area; Area striata; Area striata structure; Axon; Cell Communication and Signaling; Cell Signaling; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemosensitization; Chemosensitization/Potentiation; Computer Programs; Computer software; Cortex, Striate; Custom; Dendrites; Dendritic Spines; Depressed mood; Depression; Development; Dominance, Ocular; Electrophysiology; Electrophysiology (science); Eye; Eye Dominance; Eyeball; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; GFP; Generalized Growth; Goals; Green Fluorescent Proteins; Growth; Human, Adult; Image; Intracellular Communication and Signaling; Investigators; Label; Laser Scanning Microscopy; Length; Link; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Longitudinal Studies; Macular degeneration; Macular degenerative disease; Mammals, Mice; Maps; Measurement; Measures; Mental Depression; Mice; Mice, Transgenic; Molecular; Murine; Mus; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Ocular Dominance; Photons; Physiologic; Physiological; Play; Position; Positioning Attribute; Potentiation; Preparation; Primary visual cortex; Programs (PT); Programs [Publication Type]; Pyramidal neuron; Research Personnel; Researchers; Resolution; Role; Scanning Microscopy, Laser; Science of Anatomy; Scotoma; Sensory; Series; Signal Transduction; Signal Transduction Systems; Signaling; Silicones; Slice; Software; Sorting - Cell Movement; Spinal Column; Spine; Stimulus; Striate area; Stroke; Structure; Synapses; Synaptic; Synaptic plasticity; Testing; Therapeutic; Time; Tissue Growth; Transgenes; Transgenic Mice; Vascular Accident, Brain; Vertebral column; Visual Cortex; Visual Field Disorder; Visual field scotoma; Writing; adult human (21+); anatomy; area striata; backbone; base; biological signal transduction; brain attack; cell type; cerebral vascular accident; computer program/software; critical period; dendrite spine; density; depressed; deprivation; experience; experiment; experimental research; experimental study; fluorescent dye/probe; functional loss; hippocampal pyramidal neuron; imaging; in vivo; information processing; long term depression; long-term study; monocular; monocular deprivation; neural circuit; neural circuitry; neuronal; novel; ontogeny; optic imaging; optical imaging; postnatal; programs; receptive field; research study; response; sadness; social role; sorting; stroke; synapse formation; synaptogenesis; therapeutic development; tissue fixing; treatment strategy; visual cortical; visual field defect; visual process; visual processing",Imaging Synaptic Plasticity in the Visual Cortex in Vivo,,16052,CVP,Central Visual Processing Study Section,S2,4,153193,
8006964,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY016211-05S1,,NEI:145474;,2010,NATIONAL EYE INSTITUTE,,MIAMI,UNITED STATES,OPHTHALMOLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"LI, WEI ;",1896314;,3R01EY016211,08/01/2005,01/31/2011,"ATGN; Acute; Affect; Affinity; Animal Model; Animal Models and Related Studies; Animals; Anterior uveitis; Antibodies; Antigens; Assay; Autoantibodies; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; B blood cells; B-Cells; B-Lymphocytes; Bacteriophages; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blindness; Blood; Blood Serum; Blood monocyte; Blotting, Western; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CTL; Causality; Cell-Mediated Lympholytic Cells; Cell/Tissue, Immunohistochemistry; Ciliary Body; Clinical; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Development; Diagnosis; Disease; Disorder; Dot Immunoblotting; ELISA; ELISPOT; Enzyme-Linked Immunosorbent Assay; Etiology; Eye; Eyeball; Forecast of outcome; Gamma Globulin, 7S; Genetic; Genetics, in situ Hybridization; Goals; HLA-B27; HLA-B27 Antigen; Human; Human, General; IHC; INFLM; IgG; IgG2; IgG3; IgG4; Immune response; Immunoblotting, Dot; Immunoglobulin G; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Inflammation; Knowledge; Lead; Man (Taxonomy); Man, Modern; Marrow monocyte; Methods; Methods and Techniques; Methods, Other; Molecular Interaction; Molecular Probes; Nature; Pathogenesis; Patients; Pb element; Phage Display; Phages; Principal Investigator; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; Reticuloendothelial System, Blood; Role; Science of Statistics; Self-Antigens; Serum; Severities; Specificity; Statistics; System; System, LOINC Axis 4; T-Cell Proliferation; T-Cells; T-Lymphocyte; T-Lymphocytes, Cytotoxic; Techniques; Thymus-Dependent Lymphocytes; Tissues; Uveitis; Western Blotting; Western Blottings; Western Immunoblotting; Work; autoimmune antibody; autoimmune uveitis; bacterial virus; base; cytokine; disease causation; disease diagnosis; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; dot blotting; enzyme linked immunospot assay; gene product; heavy metal Pb; heavy metal lead; host response; immunogen; immunogenicity; immunoresponse; improved; in situ Hybridization Staining Method; model organism; monocyte; novel; outcome forecast; peripheral blood; programs; protein blotting; response; self reactive antibody; self recognition (immune); social role; statistics; thymus derived lymphocyte; tool",PROFILING AUTOANTIGENS IN UVEITIS,,16211,ZRG1,Special Emphasis Panel,S1,5,145474,
8005206,R01,EY,3,Y,01/01/2010,12/31/2010,,3R01EY016454-05S1,,NEI:68096;,2010,NATIONAL EYE INSTITUTE,,AUSTIN,UNITED STATES,PSYCHOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"SEIDEMANN, EYAL J;",8044934;,3R01EY016454,05/01/2005,12/31/2010,"Accounting; Address; Affect; Area striata; Area striata structure; Attention; Behavior; Behavioral; Behavioral Model; Brain; Cats; Cell Communication and Signaling; Cell Signaling; Cognitive; Coloring Agents; Computational Technique; Computer Simulation; Computerized Models; Cortex, Striate; Data; Detection; Domestic Cats; Dyes; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Functional Magnetic Resonance Imaging; Goals; Human; Human, General; Image; Intracellular Communication and Signaling; Knowledge; Laboratories; Link; Location; MRI, Functional; Macaca; Macaque; Magnetic Resonance Imaging, Functional; Mammals, Cats; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Mediating; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Monitor; Monkeys; Motor; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Optics; Pattern; Performance; Play; Population; Population Process; Population-Level Process; Position; Positioning Attribute; Primary visual cortex; Primates; Process; Programs (PT); Programs [Publication Type]; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Pursuit, Saccadic; Reaction Time; Reading; Reporting; Research; Resolution; Response RT; Response Time; Rest; Role; Saccades; Saccadic Eye Movements; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Staging; Stimulus; Striate area; Techniques; Testing; Time; Training; Uncertainty; V (voltage); V1 neuron; Visual; Visual Cortex; Visual Perception; Visual System; Visual system structure; area striata; attentional modulation; base; biological signal transduction; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; doubt; experiment; experimental research; experimental study; fMRI; imaging; improved; in silico; interest; millimeter; neural; neural circuit; neural circuitry; neural mechanism; neuromechanism; neuronal; optic imaging; optical imaging; programs; psycho-physiological; psychomotor reaction time; relating to nervous system; research study; response; social role; virtual simulation; visual cortical; visual information; visual neuroscience; visual stimulus; voltage",Linking neural population activity and visual perception,,16454,CVP,Central Visual Processing Study Section,S1,5,68096,
7996293,R01,EY,3,Y,01/01/2010,12/31/2010,PAR-04-514,3R01EY017210-05S1,,NEI:175049;,2010,NATIONAL EYE INSTITUTE,,SAN FRANCISCO,UNITED STATES,PHYSIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LISBERGER, STEPHEN G;",1880979;,3R01EY017210,09/15/2005,12/31/2010,"Action Potentials; Address; Animals; Architecture; Area; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Brain Stem; Brainstem; Cell Communication and Signaling; Cell Signaling; Cells; Code; Coding System; Complex; Conditioning Therapy; Decision Making; Dyskinesia Syndromes; Engineering / Architecture; Epilepsy; Epileptic Seizures; Epileptics; Equation; Eye; Eyeball; Intracellular Communication and Signaling; Life Style Modification; Mammals, Primates; Measures; Motion; Motor; Motor output; Movement; Movement Disorder Syndromes; Movement Disorders; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System Diseases; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurons; Neurophysiology - biologic function; Nystagmus, Pathologic; Outcome; Output; Pathologic Nystagmus; Pattern; Primates; Property; Property, LOINC Axis 2; Pursuit, Smooth; Research; SPEM; Seizure Disorder; Sensory; Side; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Pursuit; Structure; Synapses; Synaptic; Time; Training; Translations; Variant; Variation; Work; awake; behavior intervention; behavioral intervention; biological signal transduction; body movement; combinatorial; computerized data processing; data processing; design; designing; epilepsia; epileptiform; epileptogenic; nervous system disorder; neural; neural circuit; neural circuitry; neural function; neural patterning; neurological disease; neuronal; nystagmus; relating to nervous system; response; signal processing; smooth pursuit eye movement",Collaborative research: CRCNS: Precision and coding in smooth pursuit,,17210,ZRG1,Special Emphasis Panel,S1,5,175049,
8010023,R01,EY,3,Y,02/01/2010,01/31/2011,,3R01EY017313-03S1,,NEI:99974;,2010,NATIONAL EYE INSTITUTE,,DETROIT,UNITED STATES,OPHTHALMOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"KOWLURU, RENU A.;",2111034;,3R01EY017313,03/01/2007,01/31/2011,"3-Phosphoglyceraldehyde; 3-mononitrotyrosine; 3-nitrotyrosine; Acquired Blindness; Advanced Glycosylation End Products; Apopain; Appearance; Biochemical; Blood Glucose; Blood Sugar; Blood capillaries; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Capillaries; Capillary; Capillary, Unspecified; Caspase 3, Apoptosis-Related Cysteine Protease; Cells; Clinical Research; Clinical Study; Common Rat Strains; Complications of Diabetes Mellitus; Cysteine Protease CPP32; D-Glucose; DNA; DNA Damage; DNA Injury; Data; Dehydrogenases; Deoxyribonucleic Acid; Dextrose; Diabetes Complications; Diabetes Mellitus; Diabetes-Related Complications; Diabetic Angiopathies; Diabetic Complications; Diabetic Retinopathy; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Electron Transport; Endothelial Cells; Enzymes; Epidemiology; Ethanedial; Ethanedione; Glucose; Glycation End Products, Advanced; Glyceraldehyde 3-Phosphate; Glycosylation End Products, Advanced; Glyoxal; Histopathology; Hyperglycemia; IPO-B; Institutes; Institution; Intervention; Intervention Strategies; Investigators; MNSOD; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Measures; Memory; Messenger RNA; Metabolic; Mice; Mitochondria; Mitochondrial Superoxide Dismutase; Mitochondrial Superoxide Dismutase 2; Mn Superoxide Dismutase; Modeling; Murine; Mus; Nuclear; Oxidative Stress; Oxidoreductase; PARP Cleavage Protease; Pathogenesis; Pathology; Pathway interactions; Patients; Phosphates; Process; Programs (PT); Programs [Publication Type]; Propanal, 2-hydroxy-3-(phosphonooxy)-; Proteins; RNA, Messenger; Rat; Rat model of diabetes; Rat-1; Rat-1 Cells; Rattus; Reductases; Research Personnel; Researchers; Resistance; Retina; Retinal; Retinal Diseases; Retinal Disorder; Role; SCA-1; SOD2 protein; SOD2 protein, human; SREBP Cleavage Activity 1; Stress; Superoxide Anion; Superoxide Dismutase 2; Superoxide Radical; Superoxides; Testing; Yama; Yama protein; adult youth; advanced glycation endproduct; base; capillary; caspase-3; cysteine protease P32; denitration; diabetes; diabetes control; diabetic rat; diabetic rat model; electron transfer; experience; experiment; experimental research; experimental study; gene product; glycation; glycemic control; glyceraldehyde phosphate; human SOD2 protein; hyperglycemic; inorganic phosphate; insight; intervention effect; interventional strategy; mRNA; memory process; microvascular complications; microvascular complications of diabetes; microvascular disease; mitochondrial; mitochondrial dysfunction; nitration; nitrotyrosine; nonenzymatic glycosylation; novel; overexpression; pathway; prevent; preventing; programs; research study; resistant; retina apoptosis; retina disease; retina disorder; retinal apoptosis; retinopathy; social role; transcription factor; young adult",Glycemic Control and Progression of Diabetic Retinopathy,,17313,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,3,99974,
8004774,R01,EY,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01EY017637-02S1,,NEI:181873;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"GERHARDINGER, CHIARA ;LORENZI, MARA  (contact);",1887387 (contact);7948529;,3R01EY017637,01/01/2009,01/31/2011,"2-(Acetyloxy)benzoic Acid; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; Acetylsalicylic Acid; Address; Adventitial Cell; Affect; Age; Aldehyde Reductase; Alditol[{..}]NAD(P)+ 1-oxidoreductase; Aldose Reductase; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Aspergum; Aspirin; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Autopsy; Back; Blood Pressure, High; Blood Vessels; Blood capillaries; Body Tissues; Buccal Cavity; CTGF; Candidate Disease Gene; Candidate Gene; Capillaries; Capillary; Capillary, Unspecified; Cause of Death; Cavitas Oris; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cell-Extracellular Matrix; Cessation of life; Characteristics; Clinical; Common Rat Strains; Complications of Diabetes Mellitus; D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione; Data; Death; Development; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes, Experimental; Diabetes-Related Complications; Diabetic Complications; Diabetic Kidney Disease; Diabetic Nephropathy; Diabetic Retinopathy; Dorsum; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug effect disorder; Drugs; EC 2.7; ECM; Ecotrin; Elements; Empirin; Endothelial Cells; Entericin; Experimental Diabetes Mellitus; Extracellular Matrix; Extren; Eye; Eyeball; Family; GFAC; Gender; Gene Expression; Gene Expression Profile; Genes; Genetic; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Head and Neck, Buccal Cavity; Histopathology; Human; Human, General; Hyperglycemia; Hypertension; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; INFLM; Individual; Inflammation; Intracellular Communication and Signaling; Investigation; Kidney; Kidney Diseases; Kinases; Lead; Learning; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Measurin; Medication; Medicine; Messenger RNA; Molecular; Molecular Target; Mouth; Names; Nephropathy; Oral cavity; Oxidative Stress; Pathology; Pathway interactions; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Prevention; Prevention strategy; Preventive strategy; Process; Proteins; RNA, Messenger; Rat; Rat model of diabetes; Rattus; Receptor Protein; Renal Disease; Residual; Residual state; Retina; Retinal; Retinal Blood Vessels; Retinal Diseases; Retinal Disorder; Retinal Vessels; Role; Rouget Cells; STZ; Science of Medicine; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Streptozocin; Streptozotocin; Structure of blood vessel of retina; Syndrome; Testing; Tissues; Transphosphorylases; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vision; Work; Zanosar; abstracting; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; capillary; clinical applicability; clinical application; connective tissue growth factor; diabetes; diabetic; diabetic rat; diabetic rat model; drug action; drug development; drug/agent; efficacy testing; experiment; experimental research; experimental study; fisp12 protein; gene expression signature; gene product; glycemic control; heavy metal Pb; heavy metal lead; hyperglycemic; hyperpiesia; hyperpiesis; hypertensive disease; inhibitor; inhibitor/antagonist; insulin-like growth factor binding protein 8; interest; kidney disorder; mRNA; malformation; member; necrocytosis; necropsy; non-diabetic; nondiabetic; novel; pathway; postmortem; preclinical study; prevent; preventing; receptor; renal; renal disorder; research study; retina blood vessel structure; retina disease; retina disorder; retinopathy; small molecule; social role; sorbinil; transcriptome; vascular",Mechanisms of action of drugs that prevent experimental diabetic retinopathy," Narrative The studies proposed address diabetic retinopathy, the most common and dreaded complication of diabetes. We seek to identify processes that are active at early stages of the development of retinopathy, so that we may develop the best drug strategy for prevention of the damage inflicted by diabetes to the retinal vessels. Such work has now uncovered a possible role in diabetic retinopathy of a multifunctional growth factor named TGF-¨. TGF-¨ has been known to be involved in several vascular pathologies, but has never before been associated with diabetic retinopathy. This project intends to test whether reducing the increased TGF-¨ caused by diabetes will protect the retinal vessels from damage and ultimately death. The project is exciting for three reasons. First, it will test a new inhibitor of TGF-¨ that can be administered by mouth, and therefore would accelerate potential clinical application. Second, if the results show that returning to normal levels the excess TGF-¨ activity caused by diabetes does in fact protect the retinal vessels, we will have a precise molecular target to be brought to test for the prevention of human diabetic retinopathy. Third, being TGF-¨ implicated in multiple vascular pathologies --from kidney disease in diabetic and nondiabetic individuals, to vascular malformations in genetic syndromes, to abnormal vascular wall remodeling in hypertension and atherosclerosis--, the development of drug strategies to modulate the activity of TGF-¨ will find interest and use in several fields of medicine.",17637,BDPE,Biology and Diseases of the Posterior Eye Study Section,S1,2,181873,
8012905,R01,EY,3,,03/01/2009,02/28/2010,PA-07-070,3R01EY017673-02S2,,NEI:19764;,2010,NATIONAL EYE INSTITUTE,,IOWA CITY,UNITED STATES,PHYSIOLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"ANDERSON, MICHAEL GARY;",8294446;,3R01EY017673,04/01/2008,02/28/2013,"Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Anterior Chamber; Anterior Chamber of the Eye; Anterior chamber of eye structure; Antioxidants; Binding; Binding (Molecular Function); Blindness; CHS; CHS1; CHS1 gene; Casein Kinase TS; Casein Kinase-2; Cellular Morphology; Chediak-Higashi Syndrome 1 Gene; Color; DISSEC; Data; Development; Disease; Disorder; Dissection; Early treatment; Employee Strikes; Event; Exfoliation Syndrome; Exfoliative Syndrome; Exhibits; Eye; Eye diseases; Eyeball; Future; G-Beta Repeat; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic analyses; Genetic defect; Genetic screening method; Genetics, Human; Glaucoma; Glaucoma Capsulare; Glaucoma Simplex; Glaucoma, Compensated; Glaucoma, Compensative; Glaucoma, Open-Angle; Glaucoma, Pigmentary; Glaucoma, Simple; Goals; Human; Human Genetics; Human, General; In Vitro; Intervention; Intervention Strategies; Iris Diseases; Iris Disorder; Isoleucine; Isoleucine, L-Isomer; Knowledge; L-Isoleucine; LYST; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medical; Melanogenesis; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Modeling; Molecular Interaction; Mouse Strains; Murine; Mus; Mutant Strains Mice; Mutation; Open-Angle Glaucoma; Outcome; Oxidative Stress; Pathway interactions; Patients; Phenotype; Physiology; Pigments; Predisposition; Protein Kinase CK2; Protein Kinase CKII; Proteins; Pseudo-Exfoliation Syndrome; Pseudoexfoliation Syndrome; Research Resources; Resources; Risk; Role; Screening procedure; Strikes; Strikes, Employee; Susceptibility; Techniques; Testing; Therapeutic; Trp-Asp Repeat; Tryptophan-Aspartate Repeat; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Variant; Variation; WD Domain; WD Repeat; WD40 Domain; Work; Yeasts; age dependent; age related; anterior chamber; anti-oxidant; association test; base; casein kinase II; cell morphology; disease phenotype; disease/disorder; expectation; experiment; experimental research; experimental study; eye disorder; gene product; genetic analysis; genetic association; genetic testing; genome mutation; glaucomatous; human disease; improved; innovate; innovation; innovative; interventional strategy; model organism; mouse model; mouse mutant; mutant; ophthalmopathy; oxidative damage; pathway; protein protein interaction; research study; screening; screenings; social role; trait",Genetic dissection of pigment dispersing iris disease,,17673,AED,Anterior Eye Disease Study Section,S2,2,19764,
8012362,R01,EY,3,,09/01/2009,08/31/2010,,3R01EY018323-03S2,,NEI:44440;,2010,NATIONAL EYE INSTITUTE,,CHAPEL HILL,UNITED STATES,PHYSIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PHILPOT, BENJAMIN D;",1876114;,3R01EY018323,09/30/2007,08/31/2012,"21+ years old; Address; Adolescent; Adolescent Youth; Adult; Affect; Age; Amblyopia; Animals; Axon Terminals; Brain; Childhood; Complement; Complement Proteins; Darkness; Darknesses; Data; Development; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Excitatory Synapse; Eye; Eyeball; Glutamate Receptor; Goals; Human, Adult; Immunoelectron Microscopy; Investigators; Knowledge; Lead; Left; Life; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Synaptic Depression; Mammals, Mice; Mediating; Mice; Mice, Mutant Strains; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Modification; Murine; Mus; Mutant Strains Mice; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NR1; NR1 gene; Neocortex; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Partial Sight; Pathway interactions; Pb element; Presynaptic Receptors; Presynaptic Terminals; Prevalence; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Public Health; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Presynaptic; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Role; Sensory Deprivation; Sight; Slice; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; Synaptic plasticity; Testing; Time; Transmission; V (voltage); Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual; Visual Cortex; Visual impairment; Whole-Cell Recordings; adult human (21+); age dependent; age related; base; critical period; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; homotypical cortex; isocortex; juvenile; juvenile human; long term depression; mouse mutant; neopallium; neuronal; neurotransmitter release; novel; pathway; pediatric; postnatal; postsynaptic; presynaptic; prevent; preventing; programs; public health medicine (field); receptor; receptor function; research study; response; social role; synaptic depression; tool; transmission process; visual cortical; visual deprivation; visually impaired; voltage",Mechanisms of Presynaptic Plasticity in Visual Cortex,,18323,CVP,Central Visual Processing Study Section,S2,3,44440,
8007095,R01,EY,3,Y,01/01/2010,12/31/2010,PA-07-070,3R01EY018755-12S1,,NEI:100023;,2010,NATIONAL EYE INSTITUTE,,PORTLAND,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"JOHNSON, DAVID C.;",1885261;,3R01EY018755,07/01/1998,12/31/2010,"Address; Afferent Neurons; Animal Model; Animal Models and Related Studies; Axon; Axonal Transport; Axoplasmic Transport; Back; Binding; Binding (Molecular Function); Blindness; Body Tissues; Cell Body; Cell Isolation; Cell Junctions; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Surface Glycoproteins; Cell membrane; Cell surface; Cells; Central Nervous System; Cicatrix; Complex; Cornea; Corneal Stroma; Cytoplasmic Membrane; Disease; Disorder; Dorsum; Epithelial; Epithelial Cells; Event; Extracellular Space; Extremities; Ganglia; Ganglia, Sensory; Ganglion Cysts; Ganglionic Cysts; Ganglions; Glycoproteins; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesviridae; Herpesvirus hominis; Herpesviruses; Human; Human, General; In Vitro; Infection; Inflammatory; Intercellular Junctions; Intercellular Space; Keratitis; Ligands; Limb structure; Limbs; Man (Taxonomy); Man, Modern; Membrane; Membrane Glycoproteins; Membrane Proteins; Membrane Proteins, Viral; Membrane-Associated Proteins; Micro-tubule; Microtubules; Molecular; Molecular Interaction; Motor; Movement; Myxoid cyst; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System, CNS; Nervous system structure; Neural Cell; Neural Ganglion; Neuraxis; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurons, Afferent; Neurons, Sensory; Non-Trunk; Nuclear; Nuclear Envelope; Nuclear Inner Membrane; Nuclear Membrane; Nuclear Outer Membrane; Nucleocapsid; Plasma Membrane; Play; Process; Property; Property, LOINC Axis 2; Recurrence; Recurrent; Role; Scars; Sensory Cell Afferent Neuron; Sensory Ganglia; Simplexvirus; Site; Solid; Sorting - Cell Movement; Staging; Surface; Surface Glycoproteins; Surface Proteins; Synapses; Synaptic; Time; Tissues; Travel; VESCL; Vaccines; Vesicle; Viral; Viral M Proteins; Viral Matrix Proteins; Virion; Virus; Virus Particle; Viruses, General; anterograde transport; body movement; cell body (neuron); cell sorting; corneal; design; designing; disease/disorder; extracellular; fast axonal transport; herpes virus; herpesvirus; human herpesvirus 1 group; improved; membrane structure; model organism; mutant; neural cell body; neuronal; neuronal cell body; neuronal circuitry; pathogen; plasmalemma; social role; soma; sorting",Herpes simplex virus egress from cells and spread in neuronal axons,,18755,ZRG1,Special Emphasis Panel,S1,12,100023,
8011239,R01,EY,3,Y,02/01/2010,01/31/2011,PA-07-070,3R01EY019304-02S1,,NEI:107615;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,OTHER CLINICAL SCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KOMAROMY, ANDRAS ;",9016121;,3R01EY019304,02/01/2009,01/31/2011,"AAV vector; Affect; Age related macular degeneration; Age-Years; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Biogenesis; Biological Preservation; Blindness; Body Tissues; CNG channel (rod); Canine Species; Canis familiaris; Catalytic RNA; Clinical Trials, Phase I; Color; Color Visions; Common Rat Strains; Complementary DNA; Cone; Cones (Eye); Cones (Retina); DNA, Complementary; Data; Defect; Development; Disease; Disease Progression; Disease model; Disorder; Dogs; Drugs, Nonproprietary; Dysfunction; Early-Stage Clinical Trials; Europe; Evaluation; Eye; Eyeball; Functional disorder; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generic Drugs; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Intervention; Genetic defect; Genomics; Goals; Health; Hereditary; Hereditary Disease; Human; Human, General; Inherited; Intervention, Genetic; Lead; Life; Maculopathy, Age-Related; Mammals, Dogs; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Metric; Mice; Missense Mutation; Modality; Modeling; Molecular; Molecular Biology, Gene Therapy; Molecular Disease; Monitor; Murine; Mus; Mutation; Mutation, Missense; Origin of Life; Outer pigmented layer of retina; Patients; Pattern; Pb element; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phenotype; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photosensitive Cell; Physiopathology; Pigment cell layer of retina; Pigmentary Retinopathy; Pigmented layer of retina; Preservation, Biologic; Preservation, Biological; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; RNA, Messenger; Rat; Rattus; Recombinant adeno-associated virus; Recombinant adeno-associated virus (rAAV); Reporting; Research Proposals; Retina; Retinal; Retinal Cone; Retinal Diseases; Retinal Disorder; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Retinitis Pigmentosa; Ribozymes; Rod-Cone Dystrophy; Rodent Model; Safety; Science of Anatomy; Sight; Specificity; Staging; Structure; Structure of retinal pigment epithelium; Tapetoretinal Degeneration; Testing; Therapeutic; Therapy, DNA; Time; Tissues; Toxic effect; Toxicities; Transgenes; Translations; Treatment outcome; Vision; Visions, Color; Visual Acuity; Visual Receptor; achromatopsia; adeno-associated viral vector; adeno-associated virus vector; age effect; aging effect; anatomy; base; cDNA; canine; cationic channel protein (rod); cone cell; cyclic-nucleotide gated channel; cyclic-nucleotide gated ion channels; design; designing; disease phenotype; disease/disorder; disorder model; domestic dog; early onset; gain of function mutation; gene product; gene replacement; gene replacement therapy; gene therapy; generic; genetic disorder; genetic therapy; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; improved; loss of function mutation; mRNA; man; man's; model organism; monolayer; mutant; neurotrophic factor; neurotrophin; neutrophin; pathophysiology; phase 1 study; phase 1 trial; phase I trial; preservation; prevent; preventing; protocol, phase I; public health relevance; restoration; retina disease; retina disorder; retinopathy; senile macular disease; success; transgene expression; visual performance",Achromatopsia - Disease Mechanisms and Cone-Directed Gene Therapy,,19304,ZRG1,Special Emphasis Panel,S1,2,107615,
8012588,R01,EY,3,,04/01/2009,03/31/2010,PA-07-070,3R01EY019465-01S1,,NEI:8678;,2010,NATIONAL EYE INSTITUTE,,NEW ORLEANS,UNITED STATES,OTHER BASIC SCIENCES,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"BAZAN, HAYDEE E.P.;",1892010;,3R01EY019465,04/01/2009,03/31/2012,"15-LOX; 15-Lipoxygenase; 15-Lipoxygenase, Reticulocyte Arachidonate; 5,6,15-tri-HETE; 5,6,15-triHETE; 5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid; ALOX15; Abbreviations; Acids; Animal Model; Animal Models and Related Studies; Animals; Anterior; Apoptosis; Apoptosis Pathway; Apoptotic; Arachidonate 15-Lipoxygenase; Arachidonate Omega-6 Lipoxygenase; Arachidonate[{..}]oxygen 15-oxidoreductase; Arachidonic Acid 15-Lipoxygenase; Arachidonic Acids; Area; Autocrine Systems; CGRP; Calcitonin Gene-Related Peptide; Cell Communication and Signaling; Cell Culture Techniques; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cells; Confocal Microscopy; Contact Lenses; Cornea; Corneal Injury; Cytoplasmic Membrane; DHA; Dendrites; Diabetes Mellitus; Docosahexaenoic Acids; Docosahexenoic Acids; Dryness of eye; EC 3.1.1.4; Epithelial; Epithelial Cells; Epithelium, Anterior Corneal; Epithelium, Corneal; Euler-Gaddum Substance P; Fatty Acids; Fatty Acids, Omega-3; Frequencies (time pattern); Frequency; Gasser's Ganglion; Gasserian Ganglion; Gene Proteins; Generalized Growth; Genetic Models; Growth; HETE; Health; Human; Human, General; Hydroxyeicosatetraenoic Acids; Hypesthesia; Hypesthesia, Tactile; Hypoesthesia; Image; Impaired Sensation; In Vitro; Incidence; Infection; Injury; Intracellular Communication and Signaling; Keratectomy, Laser; Keratitis; Keratomileusis, Laser In Situ; Keratoplasty, Penetrating; Knockout Mice; LASIK; LC/MS; LOX; LOX gene; LXA4; Laboratories; Lamellar Keratoplasty; Laser In Situ Keratomileusis; Laser Intrastromal Keratomileuses; Laser Intrastromal Keratomileusis; Laser-Assisted Stromal In Situ Keratomileusis; Lecithinase A2; Lipids; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Knock-out; Mice, Knockout; Microscope; Microscopy, Confocal; Modeling; Models, Genetic; Molecular; Myofibroblast; Natural regeneration; Nerve; Nerve Cells; Nerve Regeneration; Nerve Unit; Nervous; Neural Cell; Neural Growth; Neurocyte; Neuronal Growth; Neurons; Neuropeptides; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Null Mouse; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Operation; Operative Procedures; Operative Surgical Procedures; Oryctolagus cuniculus; PLA2; Penetrating Keratoplasty; Phospholipase A2; Photokeratectomy; Photorefractive Keratectomy; Pigments; Plasma Membrane; Play; Postoperative Complications; Procedures; Protein Gene Products; Proteins; R01 Mechanism; R01 Program; RPG; Rabbit, Domestic; Rabbits; Reduced Sensation; Regeneration; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Retinal; Role; SP(1-11); Sampling; Semilunar Ganglion; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stromal Cells; Structure of corneal epithelium; Structure of trigeminal ganglion; Substance P; Surgical; Surgical Injuries; Surgical Interventions; Surgical Procedure; Testing; Therapeutic Agents; Time; Tissue Growth; Trigeminal Ganglias; Trigeminal Ganglion; Vision; Wound Healing; Wound Repair; afferent nerve; autocrine; base; biological signal transduction; brain cell; corneal; corneal epithelial; corneal epithelium; corneal surgery; corneal wound; diabetes; dry eye; eye dryness; gene product; imaging; improved; in vivo; innovate; innovation; innovative; insight; lecithinase A; lipid mediator; lipoxin A4; liquid chromatography mass spectrometry; migration; model organism; n-3 Fatty Acids; nerve injury; nervous system regeneration; neural injury; neural regeneration; neurogenesis; neurokinin 1; neuronal; neuroprotectin D1; neuroprotection; new approaches; novel approaches; novel strategies; novel strategy; omega-3; ontogeny; paracrine; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; plasmalemma; prevent; preventing; pro-apoptotic protein; protein expression; public health relevance; regenerate; repair; repaired; sensory nerve; social role; stem; surgery; tandem mass spectrometry; tissue repair",Lipid Mediators in Corneal Nerve Regeneration," PROJECT NARRATIVE The research proposed in this project focuses on enhancing the regeneration of corneal nerves damaged after corneal surgery procedures to decrease the incidence of postoperative complications by providing innovative understanding of the role lipid cell signaling mechanisms play after injury. The proposed studies target mechanisms of neuroregeneration relevant to understanding and treating complications generated by corneal nerve damage. Our novel approach will define potential therapeutic agents for neurotrophic keratitis and dry eye after refractive surgery, yielding new insights into how injuries stemming from these procedures can be repaired or prevented.",19465,AED,Anterior Eye Disease Study Section,S1,1,8678,
7999942,R01,GM,3,Y,01/29/2010,12/31/2010,,3R01GM025874-30S1,,NIGMS:184121;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,,08,120989983,US,MA,021421479,WHITEHEAD INSTITUTE FOR BIOMEDICAL RES,"LINDQUIST, SUSAN L.;",1934740;,3R01GM025874,01/29/2010,12/31/2010,"Adopted; Affect; Amyloid; Amyloid Proteins; Amyloid Substance; Animal Model; Animal Models and Related Studies; Aplysia; Benign; Biochemical; Biochemical Genetics; Biological; Biological Function; Biological Process; Biology; Cells; Chaperone; Complex; Computer-Assisted Image Analysis; Crowding; Cryo-electron Microscopy; Cryoelectron Microscopy; Cyclic Peptides; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disease; Disorder; EPR spectroscopy; Electron Cryomicroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Environment; Expression Library; Face; Fiber; Fluorescence; Fungal Genome; GWAS; Genes; Genetic; Genetic Screening; Genetic analyses; Genetic, Biochemical; Genetics-Mutagenesis; Genome, Fungal; Gln; Glutamine; Human Biology; Idiopathic Parkinson Disease; Image Analyses, Computer-Assisted; In Vitro; Investigation; Investigators; L-Glutamine; Laboratories; Laboratory Study; Learning; Lewy Body Parkinson Disease; Life; Mediating; Medicine; Memory; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Biology, Mutagenesis; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Mutagenesis; Nature; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nuclear Magnetic Resonance; ORFs; Open Reading Frames; Organism; Paralysis Agitans; Paramagnetic Resonance; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Peptide Library; Phenotype; Play; PrP Proteins; Primary Parkinsonism; Prion Proteins; Prions; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Coding Region; Proteins; Q. Levoglutamide; Reaction; Research Personnel; Researchers; Role; Route; S cerevisiae; Saccharomyces cerevisiae; Science of Medicine; Shapes; Site; Spectroscopy, ESR; Structure; Techniques; Testing; Therapeutic Intervention; Translations; Variant; Variation; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; aberrant protein folding; abnormal protein folding; amyloid structure; base; conformation; conformational conversion; conformational state; conformational transition; conformer; content based retrieval; coping; cross-link; crosslink; cryoEM; deletion library; disease/disorder; electron paramagnetic resonance spectroscopy; facial; feature detection; feature recognition; gene product; genetic analysis; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; in vivo; insight; interest; intervention therapy; living system; model organism; neurodegenerative illness; non-prion; pathologic protein folding; programs; protein aggregation; protein folding; protein mis-folding; protein misfolding; small molecule libraries; social role; sup35; termination factor; whole genome association studies; whole genome association study; yeast genetics; yeast genome; yeast prion; yeast protein",Chaperone Protein and Protein Conformational Switches,,25874,BPNS,Biophysics of Neural Systems Study Section,S1,30,184121,
8008963,R01,GM,3,Y,01/29/2010,11/30/2010,,3R01GM029028-27S1,,NIGMS:99000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,CHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SMITH, AMOS B;",1868026;,3R01GM029028,01/29/2010,11/30/2010,"2H-Pyran-2-one, 6-(14-((aminocarbonyl)oxy)-2,6,12-trihydroxy-5,7,9,11,13,15-hexamethyl-3,8,16,18-nonadecatetraenyl)tetrahydro-4-hydroxy-3,5-dimethyl-, (3S-(3alpha,4beta,5beta,6alpha(2R*,3Z,5R*,6R*,7S*,8Z,11R*,12S*,13S*,14S*,15R*,16E)))-; Anions; Architecture; Area; Biological; Biological Factors; Chemistry; Complex; Cyclization; Development; Engineering / Architecture; Factor, Biologic; Frustration; Goals; Indoles; Macrolide Antibiotics; Macrolides; Marines; Method LOINC Axis 6; Methodology; Methods; Modeling; Molecular; N element; N2 element; Natural Products; Nitrogen; O element; O2 element; Oxygen; Programs (PT); Programs [Publication Type]; Science of Chemistry; Structure-Activity Relationship; Time; Update; chemical structure function; design; designing; discodermolide; experience; flasks; nodulisporic acid A; programs; sorangicin A; spirastrellolide A; structure function relationship",Synthesis of Bioactive Natural Products,,29028,SBCA,Synthetic and Biological Chemistry A Study Section,S1,27,99000,
8008952,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM031321-26A1S1,,NIGMS:83989;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,ANATOMY/CELL BIOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"GRINNELL, FREDERICK ;",1867358;,3R01GM031321,01/28/2010,12/31/2010,"AGR16 Protein; ATP[{..}]protein-tyrosine O-phosphotransferase; Acute; Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Aging; Anabolism; Anchoring Junction; Behavior; Binding; Binding (Molecular Function); Biochemical; Biological; Blood Serum; Body Tissues; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell surface; Cells; Cellular Migration; Cicatrix; Collagen; Collagen Receptors; Collagen Type I; Connective Tissue; Couples; Coupling; DDR2; DDR2 Protein; DDR2 kinase; Development; Discoidin Domain Receptor Family Member 2; EDG5 Protein; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Edg-5 Receptor; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Exhibits; Extracellular Matrix, Integrins; Fibrin; Fibroblasts; Fibrosis; Future; G-Protein Coupled Receptor H218; GFAC; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H218 Protein; HEK3; Human; Human, General; In Vitro; Integrins; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Liquid substance; Man (Taxonomy); Man, Modern; Mechanics; Modeling; Molecular Interaction; Molecular Motors; Motility; Motility, Cellular; Myofibroblast; NTRKR3; Neurotrophic Tyrosine Kinase, Receptor-Related 3; Oncogenesis; Oncogenic; Operation; Operative Procedures; Operative Surgical Procedures; PDGF; PDGFR; PTK; PTK Receptors; Pathology; Physiology; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor Receptor; Play; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinase TKT; Receptor Protein-Tyrosine Kinases; Receptor, S1P2; Receptors, Collagen; Receptors, PDGF; Research; Role; S1P1 Receptor; Scars; Senescence; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stretching; Surgical; Surgical Interventions; Surgical Procedure; TKT; TYRO10; Testing; Tissue Engineering; Tissues; Translational Research; Translational Research Enterprise; Translational Science; Transmembrane Receptor Protein Tyrosine Kinase; Tripcellim; Trypsin; Type 1 Collagen; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptor Related to Neurotrophic TRK; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Protein Kinase TYRO 10; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; Wound Healing; Wound Repair; biological signal transduction; biosynthesis; cell motility; cell transformation; cell type; design; designing; discoidin domain receptor 2; edg-1 Protein; edg-1 Receptor; engineered tissue; experiment; experimental research; experimental study; fluid; gene product; hydroxyaryl protein kinase; insight; interventional strategy; liquid; migration; public health relevance; receptor; receptor binding; research study; response; senescent; social role; sphingosine 1-phosphate; surgery; tissue repair; transformed cells; translation research enterprise; tumorigenesis; tyrosine kinase receptor type 10; tyrosyl protein kinase; wound",Development of an In Vitro Wound Healing Model," 7. Project Narrative  Remodeling of fibrous connective tissue by fibroblasts has been implicated in diverse aspects of normal physiology and pathology including wound repair, fibrosis, scar formation, tumorigenesis, and aging. Matrix remodeling also is an important design feature in tissue engineering. Underlying our research is the premise that we can use 3D collagen matrices containing human fibroblasts to analyze and dissect the structural, functional and mechanical features of connective tissue remodeling in a tissue-like environment. Understanding these features should facilitate discovery of interventions to promote wound repair and enhance development of the field of tissue engineering. Indeed, the general usefulness of 3D matrix models to accelerate a wide range of translational research work increasingly has been recognized.",31321,SAT,"Surgery, Anesthesiology and Trauma Study Section",A1S1,26,83989,
7999955,R01,GM,3,Y,01/25/2010,12/31/2010,PA-07-070,3R01GM032443-24S1,,NIGMS:119217;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN DIEGO,UNITED STATES,BIOLOGY,53,073371346,US,CA,92182,SAN DIEGO STATE UNIVERSITY,"BERNSTEIN, SANFORD I;",1883786;,3R01GM032443,01/25/2010,12/31/2010,"ATP phosphohydrolase; ATPase; ATPase, Actin-Activated; Actin Filaments; Actins; Address; Adenosine Triphosphatase; Adenosine Triphosphatase, Myosin; Adenosinetriphosphatase; Affect; Affinity; Alternate Splicing; Alternative Splicing; Amino Acids; Animal Model; Animal Models and Related Studies; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac beta-Myosin; Cardiomyopathies; Cardiomyopathy, Hypertrophic Obstructive; Cardiomyopathy, Restrictive; Cell Locomotion; Cell Migration; Cell Movement; Cellular Inclusions; Cellular Migration; Central Core Disease; Central Core Myopathy; Characteristics; Chemicals; Combining Site; Communication; Crystallization; Crystallographies; Crystallography; DNA Molecular Biology; Defect; Development; Disorder of muscle, unspecified; Distal Muscular Dystrophies; Distal Myopathies; Dorsal; Drosophila; Drosophila genus; Drosophila melanogaster; Electron Microscopy; Elements; Embryo; Embryonic; Engineering; Engineerings; Fiber; Frequencies (time pattern); Frequency; Fruit Fly, Drosophila; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic defect; Goals; Head; Health; Heart; Heart Diseases; Human; Human Development; Human, General; Hypertrophic Cardiomyopathy; Image; In Vitro; Inclusion Bodies; Investigation; Isoforms; Kinetic; Kinetics; L-Proline; Lead; Locomotion; Man (Taxonomy); Man, Modern; Mechanics; Mediating; Microfilaments; Microscopy, Video; Modeling; Models, Genetic; Models, Molecular; Molecular; Molecular Biology; Molecular Interaction; Molecular Models; Molecular Motors; Motility; Motility, Cellular; Motor; Movement; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle function; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Diseases; Mutagenesis, Site-Directed; Mutate; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myofilaments; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, Central Core; Myopathy, unspecified; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosin Heavy Chains; Myosin V3; Myosins; Myotubes; Nucleic Acid Biochemistry, Molecular Modeling; Nucleotides; Organism; Output; Pb element; Physiologic; Physiological; Physiology; Production; Proline; Property; Property, LOINC Axis 2; Protein Isoforms; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; RNA Splicing, Alternative; Reactive Site; Resolution; Restrictive Cardiomyopathy; Rhabdomyocyte; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Role; Shy-Magee Syndrome; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Staging; Striated Muscle Tissue; Striated Muscles; Structure; Structure-Activity Relationship; Suppressor Mutations; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic Intervention; Thick Filament; Thin Filament; Transgenic Organisms; Variant; Variation; Ventricular Cardiac beta-Myosin; Video Microscopy; Videomicrography; Videomicroscopy; Whole Organism; Wing; Work; aminoacid; analog; base; beta-Myosin; beta-Myosin, Ventricular; body movement; cardiac muscle; cell motility; chemical structure function; early onset; flexibility; fruit fly; gene product; genome mutation; heart disorder; heart muscle; heavy metal Pb; heavy metal lead; human disease; hypertrophic myocardiopathy; imaging; in vitro activity; in vitro testing; in vivo; innovate; innovation; innovative; insight; interdisciplinary approach; intervention therapy; living system; model organism; molecular modeling; muscular disorder; muscular structure; mutant; myocardium disorder; myosin ATP phosphohydrolase (actin translocating); myosin heavy chain; myosin storage myopathy; novel; public health relevance; rod cell; skeletal; social role; structure function relationship; transgenic",Genetics and Molecular Biology of Myosin," Relevance We study the structural and functional differences among alternative forms of the myosin motor protein in order to elucidate how these ""isoforms"" differentially regulate contraction of various muscle types during normal locomotion. We will also examine the role of myosin mutation in muscle disease initiation and progression by developing a genetic model for myosin-based restrictive cardiomyopathy. This is relevant to human health in that mutations in myosin cause heart diseases such as dilated, restrictive and hypertrophic cardiomyopathy, as well as skeletal muscle diseases such as inclusion body myopathy, central core disease, early onset distal myopathy and myosin storage myopathy.",32443,SMEP,Skeletal Muscle and Exercise Physiology Study Section,S1,24,119217,
7988482,R01,GM,3,Y,01/21/2010,12/31/2010,,3R01GM035695-22S1,,NIGMS:137926;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOULDER,UNITED STATES,CHEMISTRY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"MCHENRY, CHARLES S;",1868197;,3R01GM035695,01/21/2010,12/31/2010,"ATP Hydrolysis; ATP gamma-S; ATPgammaS; Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid; Binding; Binding (Molecular Function); Chaperone; Chemicals; Communication; Complex; DNA; DNA Binding; DNA Binding Interaction; DNA Polymerase III; DNA Polymerase delta; DNA mapping; DNA-Dependent DNA Polymerase III; Deoxyribonucleic Acid; E coli; Escherichia coli; Event; Exhibits; FRET; Face; Fluorescence Resonance Energy Transfer; Frameshifting, Ribosomal; Frameshifting, Translational; Genes; Goals; Grant; Holoenzymes; Homologous Protein; Hydrolysis; In Vitro; Kinetic; Kinetics; Length; Link; Maps; Mediating; Methods and Techniques; Methods, Other; Molecular Chaperones; Molecular Interaction; Nucleotides; Pathway interactions; Pol III; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Protein Homolog; ProteinHomolog; Proteins; Reaction; Relative; Relative (related person); Ribosomal Frame Shifting; Ribosomal Frameshift; Ribosomal Frameshifting; Role; Slide; Solvents; Techniques; Testing; Time; Translations; adenosine 5'-(3-thio)triphosphate; adenosine 5'-(gamma-S)triphosphate; adenosine 5'-O-(3-thiotriphosphate); adenosine 5'-O-(gamma-thiotriphosphate); adenosine-5'-(3-thiotriphosphate); dimer; experiment; experimental research; experimental study; facial; gamma-thio-ATP; gene product; pathway; protein complex; replicase; research study; social role",Assembly of Replicative Complexes,,35695,ZRG1,Special Emphasis Panel,S1,22,137926,
8008946,R01,GM,3,Y,01/28/2010,12/31/2010,,3R01GM039583-21S1,,NIGMS:120000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATHENS,UNITED STATES,NONE,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"CARLSON, RUSSELL W;",1865634;,3R01GM039583,01/28/2010,12/31/2010,"2-Amino-2-Deoxyglucose; Acetylation; Acids; Animals; Bacteria; Bartonella; Biological Models; Brucella; Cell surface; Cells; Chronic; D-Glucose, 2-amino-2-deoxy-; Environment; Fabaceae; Francisella; Glucosamine; Glycans; Gram-Negative Bacteria; Host Defense Mechanism; Hydrophobicity; Infection; Invaded; LPS; Legionella; Legumes; Leguminosae; Leguminoseae; Lipid A; Lipopolysaccharides; Methylation; Model System; Models, Biologic; Modification; Molecular; N element; N2 element; NDUL; Nitrogen; Nodule; Osmolar Concentration; Osmolarity; Oxygen measurement, partial pressure, arterial; Phenotype; Phosphates; Pisum sativum; Plant Roots; Polysaccharides; Process; Protein Methylation; Rhizobium; Rochalimaea; Symbiosis; System; System, LOINC Axis 4; Very Long Chain Fatty Acid; arterial pO2; base; bean; commensalism; galacturonic acid; inorganic phosphate; mutant; oxidation; oxygen tension; pathogen; pea; pea family; root",Rhizobial Lipopolysaccharides Essential for Infection,,39583,HIBP,Host Interactions with Bacterial Pathogens Study Section,S1,21,120000,
7999969,R01,GM,3,Y,01/07/2010,12/30/2010,PA-07-070,3R01GM041402-19S1,,NIGMS:80000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,ANATOMY/CELL BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"JACOBSON, KENNETH A (contact);THOMPSON, NANCY L.;",1864249 (contact);1891804;,3R01GM041402,01/07/2010,12/30/2010,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antibodies; Antigens; Arts; Avidity; Beds; Binding; Binding (Molecular Function); Biological Models; C Type Lectin Receptors; CD209; CD209 Antigen; CD209 gene; CDSIGN; Caliber; Cell Communication and Signaling; Cell Membrane Lipids; Cell Signaling; Cell membrane; Cell surface; Cell-Adhesion Molecule Receptors; Cells; Cellular Membrane; Closure by Ligation; Cytoplasmic Membrane; DC-SIGN; DC-SIGN1; DC-specific ICAM-3 grabbing nonintegrin; DNA Molecular Biology; Dendritic Cell Specific Intercellular Cell Adhesion Molecule Grabbing Non-Integrin; Dendritic Cell-Specific ICAM3-Grabbing Nonintegrin; Dendritic Cells; Diameter; Electron Microscopy; Environment; Exhibits; Fibroblasts; Gagging; Gene Products, gag; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; Grippe; HIV; HIV Infections; HIV gp120-Binding Protein; HIV-1; HIV-1gp120 binding C-type lectin; HIV-I; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Heterogeneity; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Image; Imaging technology; Immune response; Immunodeficiency Virus Type 1, Human; Individual; Infection; Influenza; Influenza HA; Influenza Hemagglutinin; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; LAV-HTLV-III; Label; Lateral; Life; Ligand Binding; Ligands; Ligation; Light; Lipid Rafts, Cell Membrane; Lipids; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Measures; Membrane; Membrane Lipids; Membrane Microdomains; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microbe; Microscopy; Model System; Models, Biologic; Molecular; Molecular Biology; Molecular Dynamics Simulation; Molecular Interaction; Mutation; Nature; PHEMX; PHEMX Protein; PHEMX protein, human; Pan-Hematopoietic Expression Protein; Photobleaching; Photoradiation; Plasma Membrane; Process; Property; Property, LOINC Axis 2; Protein Precursors; Q-Dot; Quantum Dots; RNA, Small Interfering; Receptor Protein; Receptors, C Type Lectin; Receptors, Cell-Adhesion Protein; Reflex, Pharyngeal; Retroviral Antigen gag Protein; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Staging; Structure; Surface; T-Lymphotropic Virus Type III Infections, Human; TSSC6; TSSC6 protein, human; Techniques; Technology; Testing; Tetraspanin; Transmembrane Protein; Tumor-Suppressing STF 6 Protein; Veiled Cells; Viral; Viral Diseases; Viral gag Proteins; Virion; Virus; Virus Assembly; Virus Diseases; Virus Particle; Virus-HIV; Virus-like particle; Viruses, General; base; biological signal transduction; cell fixing; cell imaging; cellular imaging; flu infection; gag Antigens; gag Gene Products; gag Polyproteins; gag Protein; genome mutation; group specific antigen; host response; human PHEMX protein; human T cell leukemia virus III; human T lymphotropic virus III; imaging; immunogen; immunoresponse; influenza infection; lipid raft; membrane structure; molecular dynamics; mutant; nano assay; nanoassay; new therapeutic target; pan-hematopoietic expression protein, human; particle; pathogen; plasmalemma; public health relevance; receptor; siRNA; tool; tumor suppressing subtransferable candidate 6 protein, human; vaccine development; viral infection; virus infection; viruslike particle",Structure and dynamics of membrane microdomains used for viral entry and egress,,41402,BBM,Biochemistry and Biophysics of Membranes Study Section,S1,19,80000,
7999986,R01,GM,3,Y,01/07/2010,08/31/2010,,3R01GM044762-14A2S1,,NIGMS:80034;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,,02,064367329,US,PA,191112434,INSTITUTE FOR CANCER RESEARCH,"YEN, TIMOTHY ;",1901092;,3R01GM044762,01/07/2010,08/31/2010,"ATP-protein phosphotransferase; Address; Anaphase; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibodies; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Birth Defects; CENP-E; CENP-E protein; Cancer Drug; Cancers; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Signaling; Cells; Centromere; Chemotherapeutic Agents, Neoplastic Disease; Chromosome Segregation; Chromosomes; Combining Site; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Data; Defect; Development; Difficulty conceiving; EC 2.7; Event; Exhibits; FLR; Failure (biologic function); Funding; Grant; HeLa; Health; Hela Cells; Human; Human, General; INCENP; In Vitro; Infertility; Intracellular Communication and Signaling; Kinases; Kinetochores; Ligand Binding Protein; Light; M Phase; M phase (cell cycle); Macromolecular Structure; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mechanics; Mediating; Metaphase; Micro-tubule; Microtubules; Mitosis; Mitosis Checkpoint; Mitosis Stage; Mitotic; Mitotic Anaphase; Mitotic Checkpoint; Mitotic Metaphase; Modeling; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Molecular Structure; Monitor; Paper; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photoradiation; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Protein Kinase; Protein Phosphorylation; Proteins; Publishing; Reactive Site; Recruitment Activity; Reporting; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Staining method; Stainings; Stains; Structure; Testing; Time; Transphosphorylases; Tumor-Specific Treatment Agents; Work; anaphase-promoting complex; anticancer agent; anticancer drug; aurora B kinase; biological signal transduction; cancer cell; cyclosome; failure; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; in vivo; infertile; inhibitor; inhibitor/antagonist; inner centromere protein; malignancy; neoplasm/cancer; novel; phosphorylase b kinase kinase; recruit; social role; tool; unable to bear children",Kinetochore Structure and Function,,44762,ZRG1,Special Emphasis Panel,A2S1,14,80034,
8008948,R01,GM,3,Y,01/28/2010,12/31/2010,,3R01GM046422-18S1,,NIGMS:107673;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"FEDOR, MARTHA J.;",1862063;,3R01GM046422,01/28/2010,12/31/2010,"5' Untranslated Regions; 5'UTR; 8-azaadenosine; 8-azapurine; Acids; Active Sites; Address; Amines; Architecture; Assay; Award; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Catalysis; Catalytic RNA; Cations; Chemicals; Chemistry; Cleaved cell; Complex; Delta Agent; Delta Virus; Dependence; Development; Disease; Disorder; Dissociation; Engineering / Architecture; Enzymes; Equation; Equilibrium; Event; Fluorescence; Free Energy; Functional RNA; Gene Action Regulation; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Genetics-Mutagenesis; Goals; Growth and Development; Growth and Development function; H+ element; Health; Hepatitis D Virus; Hepatitis Delta Virus; Heteronuclear NMR; Heteronuclear Nuclear Magnetic Resonance; Hydrogen Bonding; Hydrogen Ions; Individual; Intervening Sequences; Introns; Investigators; Kinetic; Kinetics; Left; Ligands; Measures; Mediating; Metabolic; Metals; Methods; Microscopic; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Monitor; Mutagenesis; NMR, Heteronuclear; Non-Coding; Non-Coding RNA; O element; O2 element; Oxygen; Pathway interactions; Peptide Biosynthesis, Ribosomal; Peptidyl Transferases; Peptidyl Translocases; Peptidyl-tRNA[{..}]aminoacyl-tRNA N-peptidyltransferase; Peptidyltransferase; Phosphates; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Protons; RNA; RNA Folding; RNA Splicing; RNA, Non-Polyadenylated; Reaction; Reagent; Research Personnel; Researchers; Resolution; Ribonucleic Acid; Ribosomes; Ribozymes; Role; S element; Science of Chemistry; Sites, Active; Splicing; Structure; Sulfur; Testing; Therapeutic; Thermodynamic; Thermodynamics; Transpeptidases; Work; azaguanosine; balance; balance function; base; catalyst; cleaved; cofactor; deprotonation; disease/disorder; experiment; experimental research; experimental study; functional group; gene product; hairpin ribozyme; inorganic phosphate; insight; mRNA Leader Sequences; nucleobase; pathway; phosphodiester; programs; protein synthesis; protonation; prototype; research study; role model; social role",Catalytic Mechanisms of RNA Ezymes,,46422,MSFB,Macromolecular Structure and Function B Study Section,S1,18,107673,
7989629,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM049264-17S1,,NIGMS:174339;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLESTON,UNITED STATES,BIOCHEMISTRY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BASTIA, DEEPAK ;",1879664;,3R01GM049264,01/20/2010,12/31/2010,"Binding; Binding (Molecular Function); Biochemical; Biochemistry; Chemistry, Biological; Crystallization; DNA Binding; DNA Binding Interaction; DNA Helicases; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA unwinding enzyme; Endomycetales; Fission Yeast; Flaps; Gene Transcription; Genetic Transcription; Goals; In Vitro; Investigation; Island Flaps; Location; Modeling; Molecular Biology, Recombinant DNA; Molecular Interaction; NIH RFA; Nature; Physiologic; Physiological; Protein Binding; Proteins; RNA Expression; Recombinant DNA; Regulation; Request for Applications; Role; S cerevisiae; S pombe; Saccharomyces cerevisiae; Saccharomycetales; Scheme; Schizosaccharomyces pombe; Selection (Genetics); Site; Structure; Surgical Flaps; Testing; Transcription; Transcription, Genetic; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeast, Fission; Yeasts; gene cloning; gene product; helicase; in vivo; interest; mutant; protein complex; rDNA; social role; transcription factor; yeast genetics; yeast protein",Mechanism of Termination of DNA Replication,,49264,MGC,Molecular Genetics C Study Section,S1,17,174339,
8008953,R01,GM,3,Y,01/28/2010,11/30/2010,,3R01GM049370-15S1,,NIGMS:111502;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,ANATOMY/CELL BIOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HASHIMOTO, CARL ;",1887188;,3R01GM049370,01/28/2010,11/30/2010,"Assay; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biology; Blood Clot; Blood Clotting; Blood coagulation; Brain; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Division Cycle; Cell Signaling; Chemotherapy-Hormones/Steroids; Complex; Cues; Culicidae; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Drosophila; Drosophila genus; EC 2.7; Embryo; Embryonic; Encephalon; Encephalons; Endocrine Gland Secretion; Endopeptidase PC2; Ensure; Esteroproteases; Event; Fruit Fly, Drosophila; GFAC; Genes; Genetic; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hormones; Human Pathology; Immune response; In Vitro; Insecta; Insects; Intracellular Communication and Signaling; Invertebrates, Insects; Investigators; Kinases; L-Serine; Lead; Learning; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mediating; Memory; Methods; Molecular; Mosquitoes; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroendocrine Convertase PC2; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; PC2; PC2 Endoprotease; PC2 Protein; Parasites; Pattern; Pb element; Peptidases; Peptide Hydrolases; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Prohormone Convertase 2; Prohormone Convertase, PC2; Proinsulin Convertase 2; Proprotein Convertase 2; Proteases; Protein Cleavage; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reaction; Research Personnel; Researchers; Resistance; Role; Sequence-Specific Posttranscriptional Gene Silencing; Serine; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Serpins; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic Hormone; Time; Transgenic Organisms; Transphosphorylases; Virulence; analog; base; biological signal transduction; extracellular; fruit fly; gene product; heavy metal Pb; heavy metal lead; host response; immunoresponse; inhibitor; inhibitor/antagonist; insight; malignancy; mutant; necrocytosis; neoplasm/cancer; neurodegenerative illness; programs; resistance mechanism; resistant; resistant mechanism; response; social role; transgenic",Biology of Serine Proteases and Serpins,,49370,CDF,Cell Development and Function Integrated Review Group,S1,15,111502,
7810115,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM050403-16S1,,NIGMS:288521;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,ANATOMY/CELL BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"WEISMAN, LOIS S;",1885593;,3R01GM050403,01/28/2010,12/31/2010,"Active Follow-up; Adipocytes; Adipose Cell; Affinity; Binding; Binding (Molecular Function); Binding Proteins; Biosynthetic Proteins; Birds of Prey; Cell Communication and Signaling; Cell Signaling; Cells; Chiro-Inositol; Collaborations; Complex; Data; Defect; EC 2.7; Economics; Employment Opportunities; Eukaryota; Eukaryote; Event; Fat Cells; Follow-Up Studies; Followup Studies; Funding; Goals; Human; Human, General; In Vitro; Inositide Phospholipids; Inositol; Inositol Phosphoglycerides; Inositol Phospholipids; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Kinases; Ligand Binding Protein; Lipids; Lipocytes; Lysosomes; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mature Lipocyte; Mature fat cell; Medical; Membrane Fusion; Membrane Protein Traffic; Membrane Traffic; Mesoinositol; Metabolic Processes; Metabolism; Mice; Michigan; Minor; Modeling; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Degeneration; Neurologic; Neurological; Neuron Degeneration; Pathway interactions; Patients; Perinatal; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Protein Phosphorylation; Proteins; PtdIns; Raptors; Recombinant Proteins; Recovery; Recruitment Activity; Regulation; Research; Research Personnel; Researchers; Scientist; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small G-Proteins; Small GTPases; Stream; Testing; Transphosphorylases; Unemployment; United States National Institutes of Health; V-ATPase; V-type ATPase; Vacuole; Yeasts; biological signal transduction; eukaryotida; follow-up; gene product; insight; jobless; joblessness; mutant; neural degeneration; neurodegeneration; neuronal degeneration; novel; out of work; parent grant; pathway; public health relevance; recruit; unemployed; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",Inositol lipid regulation of membrane fusion and fission," NARRATIVE The overall goals of this application, are to 1) create employment opportunities for skilled scientists, and 2) expand the goals of the parent grant. We recently made the unexpected finding that TORC1, a key cellular regulator of critical medical importance, binds specifically and avidly to the signaling lipid PI3,5P2. We will exploit these findings to pursue new avenues to determine how TORC1 is regulated, and to uncover novel downstream TORC1 targets.",50403,ZRG1,Special Emphasis Panel,S1,16,288521,
7999992,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM051923-14S1,,NIGMS:62718;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"GOLDBERG, ALFRED L;",1880827;,3R01GM051923,01/29/2010,12/31/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 26 S proteasome complex; 26S ATP-Dependent Protease; 26S ATP-Dependent Proteasome; 26S Proteasome Complex; 26S Proteosome; 26S protease; 26S proteasome; APF-1; ATP Hydrolysis; ATP phosphohydrolase; ATP-Dependent Proteolysis Factor 1; ATPase; Active Oxygen; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Aging; Aging Process; Aging-Related Process; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological Assay; C-terminal; Cell Survival; Cell Viability; Cells; Cellular injury; Chaperone; Chemicals; Complex; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Degradation Pathway; Degradative Pathway; Disaccharides; Docking; Enzymes; Event; Free Radicals; Freezing; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Grant; HMG-20; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Hereditary; High Mobility Protein 20; Hydrolysis; Inherited; Lead; Learning; Ligand Binding Protein; Macropain; Macroxyproteinase; Mammalian Cell; Maps; Molecular; Molecular Biology, Mutagenesis; Molecular Chaperones; Molecular Interaction; Multicatalytic Proteinase; Mutagenesis; Mutation; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Normal Cell; Nucleotides; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; Pathway interactions; Pb element; Pro-Oxidants; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Cleavage; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteolysis; Proteosome; Reaction; Reactive Oxygen Species; Role; Senescence; Series; Superoxide Anion; Superoxide Radical; Superoxides; Temperature; Testing; Trehalose; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; X ray diffraction; X ray diffraction analysis; X-Ray Diffraction; Xray Diffraction; Yeasts; aberrant protein folding; abnormal protein folding; abstracting; alpha-D-Glucopyranoside, alpha-D-glucopyranosyl; base; cell damage; cell injury; cross-link; crosslink; electron acceptor; free radical oxygen; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; in vivo; multicatalytic endopeptidase complex; neurodegenerative illness; particle; pathologic protein folding; pathway; protein degradation; protein mis-folding; protein misfolding; reconstitute; reconstitution; senescent; social role; ubiquination; ubiquitin conjugation",Molecular Chaperones and Protein Degradation," Project Narrative A prominent feature of many inherited and neurodegenerative diseases and of the aging process is the accumulation of misfolded proteins, as may result from mutations or free-radical damage. The overall goal of our studies is to clarify the biochemical mechanisms by which such abnormal proteins are selectively degraded by the ubiqutin-proteasome pathway. These studies are focusing on the molecular mechanisms of the proteasome-regulatory ATPases that bind protein substrates and translocate them into the 20S proteasome for degradation and also on the functions of molecular chaperones in this degradative process.",51923,MBPP,Membrane Biology and Protein Processing Study Section,S1,14,62718,
7999994,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM052111-11S1,,NIGMS:106750;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,ANATOMY/CELL BIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"GELFAND, VLADIMIR I;",1968527;,3R01GM052111,01/14/2010,12/31/2010,"3'5'-cyclic ester of AMP; ATP Hydrolysis; ATPase, Actin-Activated; Actin Filaments; Actin-Binding Protein; Actins; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine Triphosphatase, Dynein; Adenosine Triphosphatase, Myosin; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Binding; Binding (Molecular Function); Biological Models; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell division; Cells; Cellular Migration; Chemicals; Complexes, Macromolecular; Coupling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Diffusion; Drosophila; Drosophila genus; Drosophila melanogaster; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; EC 2.7; Eukaryote; Eukaryotic Cell; Frog; Fruit Fly, Drosophila; Goals; Image; In Vitro; Intermediate Filaments; Interphase; Intracellular Communication and Signaling; Investigators; Kinases; Kinesin; Latex Bead; Libraries; Life; Link; Macromolecular Complexes; Magnetism; Measures; Mediating; Melanophores; Melanosomes; Messenger RNA; Micro-tubule; Microfilaments; Microtubules; Model System; Models, Biologic; Molecular; Molecular Interaction; Molecular Motors; Monitor; Motility; Motility, Cellular; Motor; Motor Cell; Motor Neurons; Movement; Msec; Multiple Neurofibromas; Mutate; Myofilaments; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis Syndrome; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Normal Cell; Optics; Organelles; PKA; Pathway interactions; Phagocytes; Phagocytic Cell; Phagosomes; Phosphotransferases; Pigmentation; Pigmentation physiologic function; Pigments; Platanna; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Kinase A; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Rana; Rana (genus); Regulation; Research Personnel; Researchers; Resolution; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Slide; Source; Surface; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Testing; Time; Transphosphorylases; Tubulin; Vimentin; Viscosity; Work; Xenopus; Xenopus laevis; adenosine 3'5' monophosphate; amebocyte; biological signal transduction; body movement; cAMP; cAMP-Dependent Protein Kinases; cell motility; design; designing; dynein ATP phosphohydrolase (tubulin translocating); eukaryotida; experiment; experimental research; experimental study; feeding; fruit fly; gene product; imaging; in vivo; knock-down; laser tweezer; mRNA; magnetic; millisecond; motoneuron; motor control; mutant; myosin ATP phosphohydrolase (actin translocating); neurodegenerative illness; neuronal; optical tweezers; organelle movement; overexpression; particle; pathway; permanent cell line; photoactivation; programs; protein complex; research study; social role",Regulation of Coordination of Molecular Motors,,52111,CSF,Cell Structure and Function Study Section,S1,11,106750,
7999919,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM052948-15S1,,NIGMS:175427;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"FANNING, ELLEN HOPE;",1885418;,3R01GM052948,01/08/2010,12/31/2010,"(2,6)-sialyl T antigen; Base Pairing; Binding; Binding (Molecular Function); Biochemistry; Biological Models; Body Tissues; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Extracts; Cell Signaling; Cell Survival; Cell Viability; Cell division; Cell-Free System; Cellfree System; Cells; Chemistry, Biological; Chromatin; Chromosomal Amplification; Chromosomal Duplication; Chromosomes; Complex; Copying Processes; DNA; DNA Damage; DNA Damage Repair; DNA Helicases; DNA Injury; DNA Maintenance; DNA Nicking-Closing Protein; DNA Primase; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Repair; DNA Replication; DNA Stability; DNA Synthesis; DNA Topoisomerase I; DNA Topoisomerases, Type I; DNA Type 1 Topoisomerase; DNA Untwisting Enzyme; DNA Untwisting Protein; DNA Unwinding Proteins; DNA biosynthesis; DNA polymerase alpha-primase; DNA replication factor A; DNA unwinding enzyme; DNA, Single-Stranded; DNA, Viral; Deoxyribonucleic Acid; Development; Duplicating Processes; Eukaryota; Eukaryote; Genetic Condition; Genetic Diseases; Genome; Genome Stability; Genomics; Genotoxins; Goals; Heart; Hereditary Disease; Homologous Recombinational Repair; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Knowledge; Large T Antigen; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Mediating; Model System; Models, Biologic; Molecular; Molecular Disease; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mutagens; Pathway interactions; Polymerase; Polyoma; Polyoma Viruses; Polyomavirus; Polyomavirus macacae; Polyomavirus maccacae 1; Primase; Primates; Primer Extension; Process; Programs (PT); Programs [Publication Type]; Proteins; Reaction; Recombination Repair; Regulation; Replication Process; Replication-Associated Process; Research; Role; SS DNA BP; ST antigen; SV 40; SV 40 Virus; SV40; SV40 Virus; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Simian Vacuolating Virus 40; Simian virus 40; Single-Stranded DNA; Single-Stranded DNA-Binding Protein; Site; Stability, Genomic; Stress; T Antigens; Tissues; Topoisomerase I; Type I DNA Topoisomerases; Unscheduled DNA Synthesis; Vacuolating Agent; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Viral T Antigens; Viral Tumor Antigens; Virus; Virus Transforming Antigens; Viruses, General; Work; base; biological signal transduction; design; designing; eukaryotida; gene product; genetic disorder; genome, mammalian; genotoxic agent; helicase; hereditary disorder; homologous recombination; human DNA; malignancy; mammalian genome; neoplasm/cancer; nicking closing enzyme; novel; pathway; programs; recombinational repair; reconstitute; reconstitution; relaxing enzyme; repair; repaired; replication factor A; replication protein A; s-T antigen; sialosyl-T antigen; single-strand binding protein RP-A; social role; structural biology; swivelase; untwisting enzyme; vacuolating virus; viral DNA; virus DNA; virus protein",Control of Simian Virus 40 and Cellular DNA Replication,,52948,VIRA,Virology - A Study Section,S1,15,175427,
8011926,R01,GM,3,Y,02/05/2010,09/30/2010,,3R01GM054909-14S1,,NIGMS:65000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"WOERPEL, KEITH ALLEN;",1891618;,3R01GM054909,02/05/2010,09/30/2010,"Address; Ag element; Alkenes; C element; Carbon; Chemicals; Chemistry; Complex; Development; Drug Industry; Funding; Generations; Industry, Pharmaceutic; Laboratories; Lead; Metals; Method LOINC Axis 6; Methodology; Methods; N element; N2 element; Nitrogen; O element; O2 element; Olefins; Operation; Operative Procedures; Operative Surgical Procedures; Organic Synthesis; Oxygen; Pb element; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Process; Public Health; Reaction; Reagent; Relative; Relative (related person); Science of Chemistry; Si element; Silanes; Silicon; Silicon Compounds, Unspecified; Silver; Study Section; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; cold temperature; experiment; experimental research; experimental study; functional group; heavy metal Pb; heavy metal lead; low temperature; oxidation; pi bond; public health medicine (field); research study; silane; silicon compound; silicon compounds; stereochemistry; surgery",Silacyclopropanes: Building Blocks for Organic Synthesis,,54909,SBCA,Synthetic and Biological Chemistry A Study Section,S1,14,65000,
8008951,R01,GM,3,Y,01/28/2010,11/30/2010,,3R01GM054996-12S1,,NIGMS:72743;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,CHEMISTRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GREENBERG, MARC M;",1907182;,3R01GM054996,01/28/2010,11/30/2010,"Aging; Area; Biochemistry; Biopolymers; Biotechnology; Cancer Cause; Cancer Etiology; Cancers; Causality; Cells; Cellular injury; Chemistry, Biological; Chemistry, Organic; Complex; DNA; DNA Damage; DNA Injury; Deoxyribonucleic Acid; Disease; Disorder; E coli; Electromagnetic Radiation, Ionizing; Electron Transport; Enzymes; Escherichia coli; Etiology; Family; Funding; Gene Products, RNA; Generations; Genetic Condition; Genetic Diseases; Genetics-Mutagenesis; Glean; Goals; H element; Hereditary Disease; Hydrogen; Hydroxyl; Hydroxyl Radical; In Vitro; Investigation; Ionizing radiation; Kinetic; Kinetics; Knowledge; Malignant Neoplasms; Malignant Tumor; Methods; Molecular Biology, Mutagenesis; Molecular Disease; Molecular and Cellular Biology; Mutagenesis; Nucleic Acid Binding; Nucleic Acids; Nucleotides; Oligo; Oligonucleotides; Organic Chemistry; Oxidants; Oxidizing Agents; Pathway interactions; Play; Programs (PT); Programs [Publication Type]; Public Health; RNA; RNA Folding; RNA, Non-Polyadenylated; Radiation Sensitizers; Radiation-Ionizing Total; Radiation-Sensitizing Agents; Radiation-Sensitizing Drugs; Radiosensitizing Agents; Radiosensitizing Drugs; Reaction; Reporting; Research; Research Design; Ribonucleic Acid; Role; Senescence; Site; Source; Structure; Study Type; Therapeutic Agents; Therapeutic Human Experimentation; Therapeutic Research; Tumor Cell; adduct; antitumor agent; base; cell damage; cell injury; cross-link; crosslink; cytotoxic; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; electron acceptor; electron transfer; fundamental research; genetic disorder; hereditary disorder; human disease; malignancy; migration; monomer; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; novel; novel therapeutics; nucleic acid structure; nucleobase; oxidation; pathway; programs; public health medicine (field); radiosensitizer; repair; repaired; senescent; social role; study design; therapeutic target; tool",Mechanistic Studies of Nucleic Acid Damage and Their Application,,54996,ZRG1,Special Emphasis Panel,S1,12,72743,
8000022,R01,GM,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01GM056169-13S1,,NIGMS:82495;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"WEIS, WILLIAM I;",6324765;,3R01GM056169,01/07/2010,12/31/2010,"21+ years old; 3-D structure; 3-dimensional structure; 3D structure; Aardvark; Actins; Adherens Junction; Adhering Junction; Adhesion Molecule; Adhesive Junction; Adult; Affinity; Anchoring Junction; Basic Research; Basic Science; Binding; Binding (Molecular Function); Biochemical; Bleb; Blister; Body Tissues; Bulla; Bullous Lesion; C-terminal; CAM 120/80; Cadherin-1; Cadherins; Calorimetry; Cancers; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cell Adhesion; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Fate Control; Cell Fate Regulation; Cell Junctions; Cell Signaling; Cell membrane; Cells; Cellular Adhesion; Cellular Matrix; Complex; Congenital Heart Defects; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Cytoskeletal System; Cytoskeleton; Data; Defect; Desmoplakin III; Desmosomes; Development; Dictyostelium; Dictyostelium discoideum; Disease; Disorder; E-Cadherin; EP300; EP300 gene; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Epithelium; Family; Gene Down-Regulation; Gene Targeting; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; Homolog; Homologous Gene; Homologue; Human, Adult; Intercellular Junctions; Intermediate Filaments; Intracellular Communication and Signaling; JUP; Junction Plakoglobin; Length; Link; Liver Cell Adhesion Molecules; Macula Adherens; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mechanics; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Molecular; Molecular Interaction; Mutation; N-Cadherin; N-terminal; NH2-terminal; Neoplasm Metastasis; Nephroblastoma; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nuclear; Orycteropodidae; Pathway interactions; Peptides; Phosphorylation; Physarum polycephalum; Plasma Membrane; Process; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; R01 Mechanism; R01 Program; RPG; Receptor Protein; Renal Wilms' Tumor; Reporting; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Role; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Skin; Solid; Spot Desmosome; Structure; Synapses; Synaptic; Tail; Targetings, Gene; Tissues; Titrations; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Corepressor; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Tumor Cell Migration; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Uvomorulin; VCL; Vesication; Vinculin; Vinculin (Caenorhabditis elegans clone pRB9.1 protein moiety reduced); Wilm's Tumor; Wilms Tumor; Wilms' Tumor of the Kidney; X Ray Crystallographies; X-Ray Crystallography; actin 2; actin2; adult human (21+); base; biological signal transduction; cancer cell; cancer metastasis; cell adhesion protein; cell assembly; desmoplakin; disease/disorder; gamma catenin; gene product; gene repression; genome mutation; heart defect; intracellular skeleton; liver cell adhesion molecule; malignancy; molecular assembly; molecular assembly/self assembly; molecular self assembly; neoplasm/cancer; neuronal; p300; pathway; plakoglobin; plasmalemma; public health relevance; receptor; reconstitute; reconstitution; slime mold; social role; synapse formation; synaptogenesis; three dimensional structure; transcription factor; ubiquination; ubiquitin conjugation","Catenins, cadherins and their interactions","  During development, cells differentiate and form specific contacts with other cells in order to create tissues. Defects in this process give rise to developmental abnormalities, and loss of cell-cell contacts occurs in cancer metastasis, when cancer cells escape from a solid tissue, and in other diseases. This basic research project seeks to understand the molecular assemblies responsible for these processes.",56169,ICI,Intercellular Interactions,S1,13,82495,
8000041,R01,GM,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01GM056665-11S1,,NIGMS:79132;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HARWOOD, CAROLINE STONE;",1893456;,3R01GM056665,01/07/2010,12/31/2010,"2PP2A; Agonist; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotic Therapy; Antibiotic Treatment; Antibiotics; Assay; Bacteria; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Characteristics; Chemotaxis; Chronic; Combining Site; Communities; Complex; Cystic Fibrosis; Cytoplasm; Cytoskeletal System; Cytoskeleton; DNA; DNA-Protein Interaction; Data; Deoxyribonucleic Acid; Development; Enzymes; Fluorescence Microscopy; Gene Expression; Gene Transcription; Generalized Growth; Genetic Transcription; Growth; HLA-DR Associated Protein II; Human; Human, General; Hybrids; I2PP2A; IGAAD; Immune Surveillance; Immune system; Immunologic Surveillance; Immunological Surveillance; In Vitro; Infection; Inhibitor of GZMA-Activated DNase; Intracellular Communication and Signaling; Kinetic; Kinetics; Location; Man (Taxonomy); Man, Modern; Mediating; Microbial Biofilms; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Miscellaneous Antibiotic; Modeling; Molecular Interaction; Motility; Motility, Cellular; Movement; Mucoviscidosis; Outcome; P. aeruginosa; P.aeruginosa; PHAPII; Phosphatase 2A Inhibitor I2PP2A; Phosphates; Phosphorylation; Predisposition; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; RNA Expression; Reactive Site; Receptor Protein; Repression; Research; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Set protein; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solid; Stimulus; Subcellular Process; Surface; Surveillances, Immunologic; Surveillances, Immunological; Susceptibility; System; System, LOINC Axis 4; TAF-IBETA; Template Activating Factor I Beta; Testing; Therapeutic; Thick; Thickness; Tissue Growth; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Work; antibiotic resistant; base; biofilm; biological signal transduction; bis(3',5')-cyclic diguanylic acid; body movement; body system, allergic/immunologic; c-(GpGp); c-di-GMP; cGpGp; cell motility; cyclic diguanylic acid; diguanylate cyclase; experiment; experimental research; experimental study; gene product; histidine kinase; in vitro activity; in vivo; inorganic phosphate; intracellular skeleton; mutant; ontogeny; organ system, allergic/immunologic; pathogen; prevent; preventing; protein-histidine kinase; public health relevance; receptor; reconstitute; reconstitution; research study; response; small molecule; transcription factor; treatment of bacterial diseases; treatment of bacterial infectious disease",Cyclic-di-GMP signaling in Pseudomonas aeruginosa,,56665,PCMB,Prokaryotic Cell and Molecular Biology Study Section,S1,11,79132,
8000046,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM056836-12S1,,NIGMS:104423;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"CHANG, FRED ;",1889127;,3R01GM056836,01/14/2010,12/31/2010,"ATP-protein phosphotransferase; Actins; Active Follow-up; Animal Model; Animal Models and Related Studies; Cancers; Cannot achieve a pregnancy; Cell Components; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Function; Cell Nucleus; Cell Process; Cell Structure; Cell division; Cell physiology; Cell surface; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Structures; Cellular biology; Complex; Cues; Cytokinesis; Cytoplasmic Division; Data; Deafness; Deposit; Deposition; Development; Difficulty conceiving; Disease; Disorder; Event; Filopodia; Fission Yeast; Fluorescence Microscopy; G2 Phase; G2 period; Gap Phase 2; Generalized Growth; Genetic; Growing End of the Microtubule; Growth; Human; Human, General; Infertility; Interphase; Life; Link; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medial; Micro-tubule; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Microtubules; Molecular; Morphogenesis; Nuclear; Nucleus; Pattern; Phase; Phosphorylation; Plus End of the Microtubule; Position; Positioning Attribute; Process; Protein Kinase; Protein Phosphorylation; Proteins; Regulation; S pombe; Schizosaccharomyces pombe; Second Gap Phase; Site; Specific qualifier value; Specified; Stress Fibers; Structure; Subcellular Process; Testing; Time; Tissue Growth; Work; Yeast, Fission; base; cancer cell; cell assembly; cell biology; cell growth; cell type; disease/disorder; follow-up; gene product; glycogen synthase a kinase; human disease; hydroxyalkyl protein kinase; in vivo; infertile; inhibitor; inhibitor/antagonist; malignancy; model organism; neoplasm/cancer; ontogeny; overexpression; phosphorylase b kinase kinase; polarized cell; unable to bear children",Assembly and Placement of the Cell Division Ring,,56836,CSF,Cell Structure and Function Study Section,S1,12,104423,
8013673,R01,GM,3,,09/01/2009,06/30/2010,PA-07-070,3R01GM056927-10A1S1,,NIGMS:35270;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"MOHR, IAN J.;",1887003;,3R01GM056927,05/01/1999,06/30/2013,"0-6 weeks old; 2-amino-6,9-dihydro-9-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-ribofuranosyl)-7-methyl-6-oxo-1H-purinium, hydroxide, inner salt; 5'-Adenylic acid, homopolymer; 7-methyl-GTP; 7-methylguanosine 5'-triphosphate; 7-methylguanosine triphosphate; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Affect; Alleles; Allelomorphs; Animals; Attenuated; Autoregulation; Binding; Binding (Molecular Function); Binding Proteins; Biological Function; Biological Models; Biological Process; Birth Defects; Bone Marrow; CMV; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Clinical, Transplantation, Organ; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cues; Cultured Cells; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; Diabetes Mellitus; Disease; Disorder; EC 2.7; Ensure; Family member; Fibroblasts; Fostering; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genetic Translation; Grafting Procedure; Growth and Development; Growth and Development function; HCMV; Health; Herpesviridae; Herpesvirus 1 (beta), Murid; Herpesviruses; Homeostasis; Human; Human, General; Immune system; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Inclusion Disease; Individual; Infant, Newborn; Initiation Factors; Intracellular Communication and Signaling; Investigation; Isoforms; Kinases; Knock-in; Knock-in Mouse; Learning; Ligand Binding Protein; Macromolecular Protein Complexes; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Memory; Messenger RNA; Mice; Model System; Models, Biologic; Molecular Genetic Abnormality; Molecular Interaction; Mouse Cytomegalovirus; Multiprotein Complexes; Murid herpesvirus 1; Murine; Murine Cytomegalovirus; Mus; Newborn Infant; Newborns; Normal Cell; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Pathogenesis; Pathway interactions; Patients; Peptide Biosynthesis, Ribosomal; Peptide Initiation Factors; Phosphates; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Poly A; Poly(rA); Polyribosomes; Polysomes; Process; Production; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Complex Subunit; Protein Isoforms; Protein Phosphorylation; Protein Synthesis, Ribosomal; Proteins; RNA, Messenger; Recruitment Activity; Regulation; Regulatory Protein; Reticuloendothelial System, Bone Marrow; Ribosomes; Role; Salivary Gland Virus Disease; Salivary Gland Viruses; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Stress; Transcript; Translation Initiation Factor; Translational Activation; Translational Initiation Factor; Translations; Transphosphorylases; Transplant Recipients; Transplantation Surgery; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus Diseases; Viruses, General; biological signal transduction; body system, allergic/immunologic; capping of mRNA; cell growth; cytomegalovirus group; design; designing; diabetes; disease/disorder; experiment; experimental research; experimental study; gammaherpesvirus; gene product; genetic regulatory protein; herpes virus; human cytomegalovirus; human disease; immunosuppressed patient; inhibitor; inhibitor/antagonist; inorganic phosphate; insight; m(7)GTP; m7-GTP; mRNA; mRNA Translation; mRNA capping; malignancy; neoplasm/cancer; newborn human (0-6 weeks); organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; pathogen; pathway; polyadenylate; polypeptide; protein synthesis; public health relevance; reactivation from latency; recruit; regulatory gene product; research study; response; social role; transplant patient; vaccine development; viral infection; virus infection; virus protein",Control of translation in herpesvirus infected cells," Cellular protein production is critical for many important biological processes that impact upon human health including normal cell growth, development, learning, memory and proper response to environmental stress. While protein production is highly regulated and responsive to a variety of natural cues, the regulated process of protein production is disrupted in many human diseases, including cancer, diabetes, and viral infections, resulting in significant alterations in protein production. To understand how protein production is effectively regulated in cells, our studies exploit the power of human cytomegalovirus (HCMV) to capture, engage and manipulate the complex circuitry that is vital to properly control protein production. A comprehensive picture of how protein production is controlled could contribute to new strategies of treating many human diseases, including those caused by HCMV, which despite being innocuous in most healthy individuals, causes severe disease in individuals whose immune systems are not functioning properly (including transplant recipients along with AIDS patients) and is the leading viral cause of birth defects in newborns.",56927,VIRB,Virology - B Study Section,A1S1,10,35270,
8000052,R01,GM,3,Y,01/07/2010,12/31/2010,,3R01GM057247-12S1,,NIGMS:37000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"OSTAP, E MICHAEL;",1872722;,3R01GM057247,01/07/2010,12/31/2010,"ATPase, Actin-Activated; Actin Filaments; Actin-Binding Protein; Actins; Adenosine Triphosphatase, Myosin; Binding; Binding (Molecular Function); Biochemical; Biological; Cell Communication and Signaling; Cell Locomotion; Cell Membrane Lipids; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Mechanotransduction; Cellular Migration; Cellular Regulation; Endosomes; Eukaryote; Eukaryotic Cell; Expression Profiling; Expression Signature; Family; Gene Transcription; Genes; Genetic Transcription; Goals; Head; Human; Human, General; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigation; Isoforms; Kinetic; Kinetics; Learning; Lipids; Man (Taxonomy); Man, Modern; Mechanics; Mechanosensory Transduction; Mechanotransduction, Cellular; Membrane; Membrane Lipids; Methods and Techniques; Methods, Other; Microfilaments; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Motility; Motility, Cellular; Motor; Muscle; Muscle Tissue; Myofilaments; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosin I; Myosin Type I; Myosins; Nuclear; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Play; Process; Property; Property, LOINC Axis 2; Protein Isoforms; PtdIns; RNA Expression; Receptosomes; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signal Transduction, Mechanical; Signaling; Specificity; Structure; Techniques; Transcription; Transcription, Genetic; Tropomyosin; base; biological signal transduction; cell growth regulation; cell motility; density; eukaryotida; member; membrane structure; molecuar profile; molecular signature; myosin ATP phosphohydrolase (actin translocating); physical property; sensor; social role",Cellular regulation of myosin-I,,57247,MSFC,Macromolecular Structure and Function C Study Section,S1,12,37000,
8002526,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM058017-11S1,,NIGMS:177000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EUGENE,UNITED STATES,BIOCHEMISTRY,04,948117312,US,OR,97403,UNIVERSITY OF OREGON,"BOWERMAN, BRUCE A.;",1897769;,3R01GM058017,01/14/2010,12/31/2010,"APF-1; ATP-Dependent Proteolysis Factor 1; Actin Filaments; Adaptor Protein; Adaptor Signaling Protein; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cell Cycle Progression; Cell division; Cellular Matrix; Collaborations; Collection; Complex; Cytokinesis; Cytoplasmic Division; Cytoskeletal System; Cytoskeleton; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; E3 Ligase; E3 Ubiquitin Ligase; Embryo; Embryonic; Endomycetales; FLR; Failure (biologic function); Family; Fertility/Fertilization; Fertilization; Genes; Genetic Screening; HMG-20; High Mobility Protein 20; Investigation; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Mediating; Meiosis; Micro-tubule; Microfilaments; Microtubules; Mitosis; Mitosis Stage; Mitotic spindle; Molecular Genetic; Molecular Genetics; Myofilaments; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Processed Genes; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Saccharomycetales; Sequence-Specific Posttranscriptional Gene Silencing; Specificity; Switzerland; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; Yeast, Budding; base; chromokinesin; failure; human disease; improved; insight; intracellular skeleton; katanin; malignancy; meiotic; member; mutant; neoplasm/cancer; neurodegenerative illness; novel; scaffold; scaffolding; ubiquitin-protein ligase",Cytokinesis and the Cytoskeleton in C. elegans Embryos,,58017,CSF,Cell Structure and Function Study Section,S1,11,177000,
8000056,R01,GM,3,Y,01/29/2010,12/31/2010,,3R01GM058600-08S1,,NIGMS:99135;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SYRACUSE,UNITED STATES,BIOCHEMISTRY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"WILKENS, STEPHAN ;",2269510;,3R01GM058600,01/29/2010,12/31/2010,"AIDS; ATP Hydrolysis; ATP phosphohydrolase; ATPase; ATPase Domain; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adenosine Triphosphatase; Adenosinetriphosphatase; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Architecture; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Bovine Species; Cancers; Cattle; Cell Function; Cell Process; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complex; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; DNA Sequence Rearrangement; Data; Diabetes Mellitus; Dialysis; Dialysis procedure; Disease; Disorder; Dissociation; Electron Microscopy; Engineering / Architecture; Enzymes; Eukaryota; Eukaryote; Freezing; Funding; Goals; H(+) Pump; H+ element; Human; Human, General; Hydrogen Ions; Immunologic Deficiency Syndrome, Acquired; Investigators; Knowledge; Label; Lipids; Maleimides; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Membrane; Methods; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Models, Structural; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Motors; Molecular Stereochemistry; NMR Spectroscopy; Nature; Organism; Osteoporosis; Peptide Fingerprinting; Peptide Mapping; Peptides; Peripheral; Photometry/Spectrum Analysis, Mass; Plasma Membrane; Play; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protein Complex Subunit; Protein Trafficking; Proton Pump; Protons; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Rearrangement; Regulation; Relative; Relative (related person); Research Personnel; Research Specimen; Researchers; Resolution; Roentgen Rays; Role; Rotation; Single Crystal Diffraction; Solutions; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectroscopy, NMR; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staining method; Stainings; Stains; Structural Models; Structure; Subcellular Process; System; System, LOINC Axis 4; Techniques; Testing; Traffickings, Protein; V-ATPase; V-type ATPase; Work; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; Yeasts; base; bovid; bovine; conformation; conformational state; cow; diabetes; dialysis therapy; disease/disorder; electron crystallography; enzyme activity; enzyme mechanism; eukaryotida; improved; in vivo; living system; malignancy; membrane structure; monolayer; neoplasm/cancer; neurotransmitter release; novel; nuclear magnetic resonance spectroscopy; pH Homeostasis; plasmalemma; polarized cell; prevent; preventing; programs; protein purification; protein transport; receptor mediated endocytosis; social role; stoichiometry; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",STRUCTURE OF THE VACUOLAR ATPase,,58600,ZRG1,Special Emphasis Panel,S1,8,99135,
8008945,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM059907-10S1,,NIGMS:354177;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,CHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"BERTOZZI, CAROLYN R;",1927017;,3R01GM059907,01/29/2010,12/31/2010,"Aldehydes; Anchors, Glycosylphosphatidylinositol; Animal Model; Animal Models and Related Studies; Antigenic Determinants; Architecture; B blood cells; B-Cell Antigen CD22; B-Cells; B-Lymphocyte Cell Adhesion Molecule; B-Lymphocytes; B3 antigen; Bacterial Infections; Behavior; Binding Determinants; Binding Sites; Biological; Biological Function; Biological Process; Blood Group Antigens; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD162 antigen; CD22 antigen; CD22 glycoprotein; CD22 molecule; CD62P Antigens; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell Surface Proteins; Cell membrane; Cell surface; Cell-to-Cell Interaction; Cells; Chemicals; Combining Site; Complex; Consensus Sequence; ConsensusSequence; Cysteine; Cytoplasmic Membrane; Development; Dimerization; Disease; Disorder; EC 2.4; EC 2.8.2; Engineering; Engineering / Architecture; Engineerings; Environment; Enzymes; Epitopes; Eukaryote; Eukaryotic Cell; Event; Figs; Figs - dietary; GMP-140; GPI Membrane Anchors; Generations; Glycans; Glycobiology; Glycoconjugates; Glycoinositol Phospholipid Membrane Anchor; Glycoproteins; Glycoside Transferases; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Goals; Golgi; Golgi Apparatus; Golgi Complex; Grant; Half-Cystine; Hydroxyimino Compounds; INFLM; Immune Cell Activation; Inflammation; Intracellular Communication and Signaling; L-Cysteine; LECAM-3; Leu 14; Life; Ligands; Lyb8; MUC1; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic Glycosylation; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Methods and Techniques; Methods, Other; Modification; Molecular; Mucin-1 Staining Method; Mucins; Mucus Glycoprotein; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neoplasm Metastasis; Organ; Oximes; P-Selectin; P-selectin glycoprotein ligand-1; P-selectin ligand protein; PSGL-1; Plasma Membrane; Platelet alpha-Granule Membrane Protein; Play; Polymers; Polysaccharides; Property; Property, LOINC Axis 2; Protein Dimerization; Proteins; Proteins, Cell Surface; Reactive Site; Recombinants; Research; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Selectins; Sialic Acid-Binding Immunoglobulin-Like Lectin 2; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Surface Proteins; Techniques; Technology; Tumor Cell Migration; United States National Institutes of Health; Variant; Variation; Virus; Viruses, General; Work; analog; bacterial disease; biological signal transduction; cancer metastasis; density; design; designing; disease/disorder; enzyme activity; eukaryotida; formylglycine; functional group; gene product; glycosylation; glycosyltransferase; human disease; improved; loss of function; malignancy; membrane model; membrane structure; mimetics; model organism; molecular recognition; neoplasm/cancer; novel; plasmalemma; preference; public health relevance; scaffold; scaffolding; sialic acid binding Ig-like lectin; siglec; siglec-2; small molecule; social role; sugar; sulfotransferase; tool",Chemical Cell Surface Engineering," RELEVANCE / PROJECT NARRATIVE  Complex sugars decorate the surfaces of cells, where they play a role in cell-cell interactions involved in normal biological processes and also in human disease. The goal of this research is to develop chemical tools for studying the functions of complex sugars on the cell surface. These tools will improve our understanding of how sugars contribute to diseases such as cancer and inflammation.",59907,SBCA,Synthetic and Biological Chemistry A Study Section,S1,10,354177,
8015395,R01,GM,3,,03/01/2009,02/28/2010,PA-07-070,3R01GM060574-07S2,,NIGMS:9120;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOLOGY,08,049435266,US,MA,02215,BOSTON UNIVERSITY,"MCCALL, KIMBERLY A;",1942451;,3R01GM060574,09/01/2001,02/29/2012,"Affect; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Autophagocytosis; Biological Models; Cancers; Cardiovascular Diseases; Cell Death; Cell Death Process; Cell Death, Programmed; Cell-Death Protease; Cells; Cellular Stress; Cellular biology; Cessation of life; Collection; Complex; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Drosophila; Drosophila genus; Family member; Flies; Fruit Fly, Drosophila; Genes; Genetic; Genetic Screening; Genital System, Female, Ovary; Goals; Human; Human, General; Humulin R; ICE-like protease; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Signaling Pathway; Insulin, Regular; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mitochondria; Model System; Modeling; Models, Biologic; Molecular; Morphology; Nature; Necrosis; Necrotic; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Novolin R; Nurses; Nutrition; Nutritional Science; Oogenesis; Ovarian; Ovary; Pathway interactions; Personnel, Nursing; Phenotype; Play; Proto-Oncogene, Signaling Factor; Relative; Relative (related person); Research; Role; Science of nutrition; Signal Pathway; Signaling Pathway Gene; Stress; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; TEM; Testing; Transmission Electron Microscopy; autophagy; cardiovascular disorder; caspase; cell biology; cystein protease; cystein proteinase; cysteine endopeptidase; disease/disorder; egg; experiment; experimental research; experimental study; fat metabolism; fly; fruit fly; gene function; insight; insulin signaling; lipid metabolism; malignancy; mitochondrial; mitochondrial autophagy; mutant; necrocytosis; neoplasm/cancer; neurodegenerative illness; new therapeutic target; novel; nutrition; pathway; public health relevance; research study; response; social role",Programmed Cell Death in Drosophila Development,,60574,DEV1,Development - 1 Study Section,S2,7,9120,
7990313,R01,GM,3,Y,01/01/2010,11/30/2010,PA-07-070,3R01GM060804-10S1,,NIGMS:114516;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,ANATOMY/CELL BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"DINARDO, STEPHEN FRANCIS;",1891703;,3R01GM060804,01/01/2010,11/30/2010,"Accounting; Address; Adopted; Affect; Anaplastic; Autoregulation; Biology; Body Tissues; Cancer stem cell; Cell Communication; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Characteristics; Cytokine Signal Transduction; Cytokine Signaling; Data; Development; Drosophila; Drosophila genus; Ectopic Expression; Employee Strikes; Erinaceidae; Fruit Fly, Drosophila; Funding; Gametes; Gene Targeting; Genes; Genetic; Genital System, Male, Testis; Germ Cells; Germ-Line Cells; Goals; Hedgehog (Hh) signal transduction pathway; Hedgehogs; Homeostasis; Intracellular Communication and Signaling; Maintenance; Maintenances; Mediating; Modeling; Molecular; Mother Cells; Neural Stem Cell; Operation; Operative Procedures; Operative Surgical Procedures; Pathway interactions; Physiological Homeostasis; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Recruitment Activity; Regenerative Medicine; Reproductive Cells; Resolution; Role; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Somatic Cell; Spermatogenesis; Stem cells; Strikes; Strikes, Employee; Supporting Cell; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Targetings, Gene; Testicles; Testis; Tissues; Touch; Touch sensation; Undifferentiated; Work; biological signal transduction; cell behavior; cell type; daughter cell; design; designing; expectation; experiment; experimental research; experimental study; fruit fly; gene product; hedgehog signaling pathway; hh signaling pathway; initial cell; interest; mutant; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; pathway; programs; public health relevance; recruit; research study; self-renewal; sexual cell; smoothened signaling pathway; social role; stem cell biology; stem cell division; stem cell niche; stem cell population; surgery",Stem Cell Renewal and Differentiation in Spermatogenesis,,60804,DEV1,Development - 1 Study Section,S1,10,114516,
8011131,R01,GM,3,,07/01/2009,06/30/2010,PA-01-049,3R01GM062357-08S1,,NIGMS:53784;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,CHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"WALTER, NILS G;",6490199;,3R01GM062357,01/01/2001,06/30/2011,"AIDS Virus; Acids; Address; Anticodon; Biochemical; Biological; Biological Models; Catalysis; Catalytic RNA; Chemicals; Chemistry; Code; Coding System; Codon; Codon Nucleotides; Complex; Computer Simulation; Computerized Models; DNA Sequence Rearrangement; Delta Agent; Delta Virus; Dependence; E coli; Escherichia coli; FRET; Fluorescence; Fluorescence Resonance Energy Transfer; Free Energy; Funding; Gene Products, RNA; Genetic; Genome, Human; Genomics; Goals; HIV-1; HIV-I; HIV1; Heart; Hepatitis D Virus; Hepatitis Delta Virus; Human; Human Genome; Human immunodeficiency virus 1; Human, General; Immunodeficiency Virus Type 1, Human; In Vitro; Investigators; Label; Life; Link; Man (Taxonomy); Man, Modern; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Method LOINC Axis 6; Methodology; Model System; Modeling; Models, Biologic; Models, Computer; Modification; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Stereochemistry; Msec; Nucleotides; Process; Programs (PT); Programs [Publication Type]; Proteins; Quantum Mechanics; RNA; RNA Sequences; RNA, Non-Polyadenylated; Reaction; Rearrangement; Research Personnel; Researchers; Resolution; Ribonucleic Acid; Ribozymes; Role; Sampling; Science of Chemistry; Sequences, RNA; Simulation, Computer based; Site; Solutions; Structure; Testing; Validation; Variant; Variation; base; computational modeling; computational models; computational simulation; computational tools; computer based models; computer based prediction; computerized modeling; computerized simulation; computerized tools; conformation; conformational state; fluorophore; gene product; hammerhead ribozyme; human T cell leukemia virus III; human T lymphotropic virus III; improved; in silico; millisecond; molecular dynamics; molecular mechanics; movie; mutant; pathogen; predictive modeling; programs; single-molecule FRET; single-molecule fluorescence resonance energy transfer; smFRET; social role; tool; virtual simulation",U-turn of the Hepatitis Delta Virus Ribozyme,,62357,MSFB,Macromolecular Structure and Function B Study Section,S1,8,53784,
7990800,R01,GM,3,Y,01/01/2010,11/30/2010,,3R01GM063789-07S1,,NIGMS:104418;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAMPAIGN,UNITED STATES,BIOCHEMISTRY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"MARTINIS, SUSAN A;",1863103;,3R01GM063789,01/01/2010,11/30/2010,"Acids; Active Sites; Address; Amino Acids; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases; Amino Acyl-tRNA Synthetases; Amino Acylation; Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Synthetase; Aminoacylation; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Cell Survival; Cell Viability; Cells; Chemistry, Biological; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Custom; DNA Molecular Biology; Development; E coli; Engineering; Engineerings; Ensure; Enzymes; Escherichia coli; Event; Family; Funding; Future; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hydrolysis; Individual; Interdisciplinary Research; Interdisciplinary Study; Investigation; Investigators; L-Leucine; Leu-tRNA; Leucine; Leucine, L-Isomer; Life; Ligase; Link; Miscellaneous Antibiotic; Modeling; Molecular; Molecular Biology; Molecular Interaction; Multidisciplinary Collaboration; Multidisciplinary Research; Mutation; Organism; Pathway interactions; Peptide Biosynthesis, Ribosomal; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Reports, Progress; Research; Research Personnel; Researchers; Ribonucleic acids, transfer; Ribosomes; Screening procedure; Single Crystal Diffraction; Site; Sites, Active; Study, Interdisciplinary; Synthetases; Therapeutic; Transfer RNA; Transfer RNA Acylation; Transfer RNA Amino Acylation; Transfer RNA Aminoacylation; Transfer RNA Charging; Transfer RNA Chargings; Transfer RNA Synthetase; Translations; Triplet Codon-Amino Acid Adaptor; X Ray Crystallographies; X-Ray Crystallography; Yeasts; adenylate; aminoacid; aminoacid tRNA ligase; base; computational chemistry; design; designing; gene product; genome mutation; in vivo; interdisciplinary collaboration; leucine-tRNA; leucyl-tRNA; living system; molecular site; mutant; novel; pathway; polypeptide; programs; protein synthesis; screening; screenings; tRNA; tRNA Acylation; tRNA Amino Acylation; tRNA Aminoacylation; tRNA Charging; tRNA Chargings; tRNA Synthetase; tRNA, leucine-; tool",tRNA Synthesis Fidelity Mechanisms,,63789,MGC,Molecular Genetics C Study Section,S1,7,104418,
8000075,R01,GM,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01GM064624-06A2S1,,NIGMS:106029;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,ANATOMY/CELL BIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"GROSS, STEVEN P;",1874051;,3R01GM064624,01/07/2010,12/31/2010,"Adenosine Triphosphatase, Dynein; Binding; Binding (Molecular Function); Biochemical; Biological; Biological Models; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Development; Drops; Drosophila; Drosophila genus; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Embryo; Embryonic; Endocytosis; Endosomes; Equilibrium; Family member; Fruit Fly, Drosophila; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Grant; Growing End of the Microtubule; Health; In Vitro; Individual; Intracellular Transport; Kinesin; Lead; Length; Light; Link; Lipids; Locomotor Activity; M Phase; M phase (cell cycle); Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Micro-tubule; Microtubules; Mitochondria; Mitosis; Mitosis Stage; Model System; Modeling; Models, Biologic; Models, Theoretic; Molecular; Molecular Interaction; Molecular Motors; Monitor; Motion; Motor; Motor Activity; Mutation; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neuron Degeneration; Neurons; Optics; Pb element; Photoradiation; Play; Plus End of the Microtubule; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Production; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Public Health; Publishing; Receptor Protein; Receptosomes; Regulation; Relative; Relative (related person); Resolution; Role; Running; Subcellular Process; System; System, LOINC Axis 4; Techniques; Technology; Testing; Theoretical model; Travel; Variant; Variation; Virus; Viruses, General; War; Work; balance; balance function; base; design; designing; dosage; dynein ATP phosphohydrolase (tubulin translocating); fruit fly; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; insight; laser tweezer; mitochondrial; mutant; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; optical tweezers; particle; protein function; public health medicine (field); public health relevance; receptor; simulation; single molecule; social role; trafficking; ward",In vivo regulation of bi-directional transport," Bi-directional transport is directly related to public health: viruses such as herpes spread through cells in a bi-directional manner; many important cargos like mitochondria and endosomes move bi-directionally. Impaired vesicular transport is implicated in Neuronal degeneration. Finally, a better understanding of transport might allow the design of new drug delivery systems.",64624,ZRG1,Special Emphasis Panel,A2S1,6,106029,
8005210,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM065386-08S1,,NIGMS:123239;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"DENU, JOHN M;",1893827;,3R01GM065386,01/14/2010,12/31/2010,"3,4',5-stilbenetriol; 3,5,4'-trihydroxystilbene; AADPR; ADP ribosylation; Acetate Thiokinase; Acetate-CoA Ligase; Acetate[{..}]CoA ligase (AMP-forming); Acetothiokinase; Acetyl Activating Enzyme; Acetyl CoA Synthetase; Acetyl Coenzyme A Synthetase; Address; Adenosine-Diphosphate-Ribose, O-Acetyl-; Age; Aging; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Cancers; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Stress; Chemistry; Chromatin; Cleaved cell; Coupled; DNA Damage Repair; DNA Repair; Deacetylation; Dependence; Detection; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Enzymatic Biochemistry; Enzymes; Enzymology; Family; Gene Inactivation; Gene Silencing; Generations; Genetic; Goals; Health Benefit; Histones; Human; Human, General; In Vitro; Intermediary Metabolism; Intracellular Second Messengers; Investigation; Ion Channel; Ionic Channels; Knowledge; Length of Life; Ligands; Longevity; MAC393 antigen; METBL; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Measures; Membrane Channels; Metabolic Processes; Metabolism; Metallopeptidases; Metalloproteases; Metalloproteinases; Molecular; Molecular Interaction; Mono ADPribose Transferases; Mono(ADP-Ribose) Transferases; Mono(ADP-Ribosyl)transferase; Mono(ADPribosyl)transferase; Mono-ADP-Ribosyltransferase; Mono-S; MonoADPribosyltransferase; MonoS; Nerve Degeneration; Neurologic; Neurological; Neuron Degeneration; O-Acetyl-ADP-Ribose; Organ System, Cardiovascular; Organism; Pathway interactions; Peptide Library; Phenotype; Plants; Plants, General; Play; Protein Acetylation; Protein Family; Proteins; Publishing; Reaction; Reporting; Resistance; Resveratrol; Role; SGP-2 protein; SGP2; SP 40,40 protein; Science of Chemistry; Screening procedure; Second Messenger Systems; Second Messengers; Senescence; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirtuins; Subcellular Process; Substrate Specificity; TRPM-2 protein; TRPM2; Testing; Unscheduled DNA Synthesis; Vascular, Heart; X-ray-inducible protein 8; XIP8 protein; Yeasts; analog; apoJ protein; apolipoprotein J; base; circulatory system; cleaved; clusterin; complement lysis inhibitor; complement-associated protein SP-40,40 protein; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; genetically modified cells; improved; in vivo; inhibitor; inhibitor/antagonist; ionizing radiation-induced protein-8; life span; lifespan; living system; malignancy; metalloproteinase (general); neoplasm/cancer; neural degeneration; neurodegeneration; neuronal degeneration; novel; nudix hydrolase; pathway; polyphenol; repair; repaired; research study; resistant; screening; screenings; second messenger; senescent; small molecule; social role; sulfated glycoprotein 2; testosterone-repressed prostate message-2 protein; tissue/cell culture; tool",Reversible Protein Acetylation and Chromatin Function,,65386,MSFA,Macromolecular Structure and Function A Study Section,S1,8,123239,
8000099,R01,GM,3,Y,01/14/2010,12/31/2010,PA-07-070,3R01GM065447-06A2S1,,NIGMS:80000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DAVIS,UNITED STATES,NEUROSCIENCES,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHEN, TSUNG-YU ;",6872950;,3R01GM065447,01/14/2010,12/31/2010,"Affect; Amino Acids; Autoregulation; BSF3; Binding; Binding (Molecular Function); Binding Sites; Biophotonics; C-terminal; CIC-1 protein; CLC; CLC Gene; CLC-1 channel; CLC-1 protein; Cell Function; Cell Process; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chloride; Chloride Channels; Chloride Ion; Chlorides; Cl- element; Combining Site; Cysteine; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; DNA Sequence Rearrangement; Data; Defect; Disease; Disorder; Disorder of muscle, unspecified; Dysfunction; FRET; Fluorescence Resonance Energy Transfer; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Half-Cystine; Hand; Hereditary; Homeostasis; Imaging Procedures; Imaging Techniques; Individual; Inherited; Ion Channel; Ion Channels, Chloride; Ion Transport; Ionic Channels; Ions; L-Cysteine; Lead; Life; Ligands; Link; Mediating; Membrane; Membrane Channels; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Motion; Movement; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Disease; Muscle Disorders; Muscle Fatigue; Muscle Tissue; Muscle disease or syndrome; Muscle function; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Diseases; Muscular Fatigue; Mutagenesis; Mutation; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotonia; Operation; Operative Procedures; Operative Surgical Procedures; Organism-Level Process; Organismal Process; Oxidants; Oxidation-Reduction; Oxidizing Agents; Pb element; Physiologic; Physiologic Processes; Physiological; Physiological Homeostasis; Physiological Processes; Physiology; Physiopathology; Plasma Membrane; Play; Process; Reactive Site; Rearrangement; Redox; Regulation; Research; Role; Skeletal Muscle Tissue; Skeletal muscle structure; Structure; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; TM Domain; Technics, Imaging; Techniques; Therapeutic; Transmembrane Domain; Transmembrane Region; V (voltage); Work; aminoacid; base; body movement; dimer; disease/disorder; electron acceptor; fluorescence imaging; genome mutation; heavy metal Pb; heavy metal lead; human disease; inhibitor; inhibitor/antagonist; insight; interest; membrane structure; muscular disorder; mutant; nano machine; nanomachine; oxidation; oxidation reduction reaction; pathophysiology; plasmalemma; public health relevance; skeletal muscle chloride channel CIC-1; social role; surgery; voltage",Molecular Physiology of CLC Chloride Channels," Project Narrative This application will study CLC channels, which are chloride channels critical for chloride ion transports across cell membranes. In particular, the slow/common-gating mechanisms of CLC-0 and CLC-1 will be studied, and the regulation of common-gating mechanism of CLC-1 by intracellular ATP and oxidants will be examined. Illustrating the underlying mechanisms of the interactions of the channel with these physiological ligands will further our understanding of the molecular functions of CLC-1 channels in muscle physiology and may help develop therapeutic strategies in treating diseases, such as myotonia, resulting from CLC channel defects.",65447,BPNS,Biophysics of Neural Systems Study Section,A2S1,6,80000,
8000101,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM065940-08S1,,NIGMS:100460;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BRONX,UNITED STATES,PHYSIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"SHARP, DAVID JAMES;",1879894;,3R01GM065940,01/14/2010,12/31/2010,"Anaphase; Biochemical; Birth Defects; Cancers; Causality; Cell Locomotion; Cell Migration; Cell Movement; Cell division; Cells; Cellular Migration; Centrosome; Chromatids; Chromosome Segregation; Chromosomes; Complement; Complement Proteins; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DISSEC; Defect; Disease; Disorder; Dissection; Drosophila; Drosophila genus; Drosophila melanogaster; Embryo; Embryonic; Enzymes; Etiology; Fruit Fly, Drosophila; GeneHomolog; Goals; Growing End of the Microtubule; Homolog; Homologous Gene; Homologue; Human; Human, General; Imagery; Kinesin; Kinetochores; Lead; Life; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Micro-tubule; Microscopic; Microtubule Depolymerization; Microtubules; Minus End of the Microtubule; Mitosis; Mitosis Stage; Mitotic Anaphase; Mitotic spindle; Modeling; Molecular; Molecular Genetic Abnormality; Motility; Motility, Cellular; Motion; Motor; Nongrowing End of the Microtubule; Oncogenesis; Pathway interactions; Pb element; Phosphorylation; Plus End of the Microtubule; Process; Protein Array; Protein Phosphorylation; Proteins; Recruitment Activity; Regulation; Sister Chromatid; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Tubulin; Visualization; Work; base; cell motility; depolymerization; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; embryo cell; fruit fly; gene product; heavy metal Pb; heavy metal lead; insight; katanin; malignancy; neoplasm/cancer; pathway; polymerization; protein function; recruit; spastin; spastin B; tissue/cell culture; tumorigenesis","Molecular Dissection of the ""Pacman-Flux"" Machinery Used to Move Chromosomes",,65940,NDT,Nuclear Dynamics and Transport,S1,8,100460,
7993678,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM066094-06A2S1,,NIGMS:27936;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BUFFALO,UNITED STATES,BIOCHEMISTRY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"SUTTON, MARK D.;",2245295;,3R01GM066094,01/08/2010,12/31/2010,"Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Area; Assay; Bacteria; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Biological Models; Bypass; CHIP assay; Cancers; Cell Cycle; Cell Division Cycle; Cells; ChIP (chromatin immunoprecipitation); Complex; DNA; DNA Damage Repair; DNA Polymerase II; DNA Polymerase III; DNA Polymerase IV; DNA Polymerase beta; DNA Polymerase delta; DNA Polymerase epsilon; DNA Polymerases; DNA Repair; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; DNA-Dependent DNA Polymerase II; DNA-Dependent DNA Polymerase III; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Development; E coli; E coli replicase; EC 2.7.7.7; Escherichia coli; Event; FLR; Failure (biologic function); Family; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Genetic, Biochemical; Genetics-Mutagenesis; Genome Stability; Goals; Hand; Holoenzymes; Human; Human, General; Ig Somatic Hypermutation; Immune Globulins; Immunoglobulin Somatic Hypermutation; Immunoglobulins; Immunoglobulins / Antibodies; In Vitro; Laboratories; Lead; Life; Literature; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Miscellaneous Antibiotic; Model System; Modeling; Models, Biologic; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Mutation; Organism; Pathogenesis; Pb element; Phenotype; Play; Pol II; Pol III; Polymerase; Process; Programs (PT); Programs [Publication Type]; Proteins; Reagent; Recycling; Regulation; Replication Error; Replication Initiation; Research; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Role; Slide; Somatic Hypermutation, Immunoglobulin; Stability, Genomic; Stress; Structure; Surface; Testing; Time; Travel; Unscheduled DNA Synthesis; Variant; Variation; Work; antibiotic resistant; base; chromatin immunoprecipitation; experience; experiment; experimental research; experimental study; failure; gene product; genetic analysis; genome mutation; heavy metal Pb; heavy metal lead; human disease; in vitro Assay; in vivo; living system; malignancy; meetings; mutant; neoplasm/cancer; novel; prevent; preventing; programs; public health relevance; repair; repaired; replicase, E coli; research study; social role; somatic hypermutation",Regulation of DNA replication and repair," PROJECT NARRATIVE: Failure to coordinate the actions of the different replication and repair factors leads to a loss of genetic fidelity and contributes to human disease. Since mechanisms of replication and repair are remarkably well conserved from bacteria to humans, we will utilize Escherichia coli as a model system to understand how the actions of different replication and repair factors are coordinately regulated with each other. We anticipate that our results will serve as a framework for understanding similar control networks in humans, were the complexity of the events is far greater, and as such, will contribute to our understanding of mechanisms contributing to cancer and other human diseases.",66094,PCMB,Prokaryotic Cell and Molecular Biology Study Section,A2S1,6,27936,
7993689,R01,GM,3,Y,01/15/2010,12/31/2010,,3R01GM066258-08S1,,NIGMS:161402;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WASHINGTON,UNITED STATES,,00,072641707,US,DC,20005,"CARNEGIE INSTITUTION OF WASHINGTON, D.C.","WANG, ZHIYONG ;",6973180;,3R01GM066258,01/15/2010,12/31/2010,"14-3-3 Proteins; Affect; Agriculture; Animals; Arabidopsis; Binding; Binding (Molecular Function); Biochemical; Biological; Biological Models; Brain 14-3-3 Protein; CHIP assay; Cancers; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Nucleus; Cell Signaling; Cell membrane; Cell surface; Cell-to-Cell Interaction; Cells; ChIP (chromatin immunoprecipitation); Chemotherapy-Hormones/Steroids; Cytoplasmic Membrane; DNA Binding; DNA Binding Interaction; DNA-Binding Proteins; Development; Developmental Process; Disease; Disorder; EC 2.7; Endocrine Gland Secretion; Funding; GFAC; Gene Expression; Gene Targeting; Gene Transcription; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Transcription; Genomics; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Growth and Development; Growth and Development function; Health; Homolog; Homologous Gene; Homologue; Hormonal; Hormones; Human; Human, General; Intracellular Communication and Signaling; Investigation; Kinases; Laboratories; Location; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Membrane; Model System; Models, Biologic; Molecular Interaction; Nuclear; Nuclear Receptors; Nucleus; Organ; Organism; Pathway interactions; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Phytohormones; Plant Growth Regulators; Plant Hormones; Plants; Plants, General; Plasma Membrane; Play; Programs (PT); Programs [Publication Type]; Protein Cleavage; Protein Phosphorylation; Proteins; Proteolysis; Proteomics; RNA Expression; Receptor Protein; Regulation; Role; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Protein; Specificity; Steroid Compound; Steroids; Targetings, Gene; Therapeutic Hormone; Therapeutic Steroid Hormone; Tissue Growth; Transcription; Transcription, Genetic; Transphosphorylases; agricultural; biological signal transduction; cell type; chemical genetics; chromatin immunoprecipitation; disease/disorder; experiment; experimental research; experimental study; gene product; living system; malignancy; membrane structure; mutant; neoplasm/cancer; non-genomic; nongenomic; novel; ontogeny; pathway; plant development; plant growth; plant growth/development; plasmalemma; programs; receptor; receptor binding; research study; response; social role; steroid hormone; transcription factor",Genetic Biochemical Studies of Plant Steroid Signaling,,66258,MGB,Molecular Genetics B Study Section,S1,8,161402,
8000107,R01,GM,3,Y,01/14/2010,12/31/2010,PA-07-070,3R01GM066817-06A1S1,,NIGMS:99710;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ROBINSON, DOUGLAS N;",1880050;,3R01GM066817,01/14/2010,12/31/2010,"Actins; Affect; Aneuploid; Aneuploidy; Anti-Cancer Agents; Anti-Oncogenes; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogenes; Antiproliferative Agents; Antiproliferative Drugs; Behavior; Biochemical; Cancer Drug; Cancer Treatment; Cancers; Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester; Cell Adhesion; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Function; Cell Process; Cell Shape; Cell Signaling; Cell division; Cell physiology; Cells; Cellular Adhesion; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Chemotherapeutic Agents, Neoplastic Disease; Computer Architectures; Crosslinker; Cytokinesis; Cytoplasmic Division; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; DISSEC; Data; Daughter; Dependency; Dependency (Psychology); Disease; Disorder; Dissection; Drosophila polo protein; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Emerogenes; Event; Evolution; FLR; Failure (biologic function); Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Goals; Grant; Human; Human, General; INCENP; Image; Intracellular Communication and Signaling; Lead; Life; Link; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Mechanical Stress; Mechanics; Mediating; Micro-tubule; Microtubules; Modeling; Molecular; Mothers; Myosin II; Myosin Type II; Nocodazole; Normal Cell; Oncodazole; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Pathway interactions; Pb element; Plasmids; Process; Property; Property, LOINC Axis 2; Proteins; RNA-Binding Proteins; Race; Racial Group; Regulatory Pathway; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Stocks, Racial; Stress; Stress, Mechanical; Structure; Subcellular Process; System; System, LOINC Axis 4; Testing; Tetraploidy; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor-Specific Treatment Agents; Work; anticancer agent; anticancer drug; anticancer therapy; aurora kinase; base; biological signal transduction; cancer cell; cancer therapy; cell growth; chemical genetics; clinical applicability; clinical application; cross-link; crosslink; daughter cell; disease/disorder; emotional dependency; failure; gene function; gene product; heavy metal Pb; heavy metal lead; imaging; in vivo; inhibitor; inhibitor/antagonist; inner centromere protein; interest; loss of function; malignancy; mutant; neoplasm/cancer; network architecture; novel; oncosuppressor gene; particle; pathway; physical property; polo kinase; polo protein; polo protein, Drosophila; public health relevance; reconstitute; reconstitution; response; small molecule; tumor",The Biochemical Basis for the Mechanics of Cytokinesis," Narrative Of great importance for normal cell growth and disease processes such as cancer, cytokinesis has the promise of providing a rich source of new anti-cancer drug targets. We are striving to understand how cytokinesis works at a fundamental level and how the cell uses proteins to generate the physical features of contractility. Ultimately, with a rigorous understanding and a complete molecular handle on the process, it should be possible to develop better cancer therapies that are tailored to the properties of specific types of cancer cells.",66817,CSF,Cell Structure and Function Study Section,A1S1,6,99710,
7993700,R01,GM,3,Y,01/07/2010,12/31/2010,PA-07-070,3R01GM067030-06A2S1,,NIGMS:139092;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"ZHANG, JIANZHI ;",7043991;,3R01GM067030,01/07/2010,12/31/2010,"Address; Assay; Bioassay; Biodiversity; Biologic Assays; Biological; Biological Assay; Biological Diversity; Biological Function; Biological Models; Biological Process; CNP; Code; Coding System; Compensation; Copy Number Polymorphism; Custom; Data; Data Set; Dataset; Duplicate Genes; Endomycetales; Evolution; Financial compensation; Fixation; Gene Copy Number; Gene Dosage; Gene Duplication; Gene Expression; Gene Family; Genes; Genes, Duplicate; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genome; Genomics; Grant; Health; Hereditary Disease; Human; Human, General; Individual; Kluyveromyces; Laboratories; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mice; Model System; Modeling; Models, Biologic; Molecular; Molecular Disease; Murine; Mus; Mutation; Nucleases, RNA; Organism; Pancreatic RNase; Pancreatic ribonuclease; Pattern; Prevalence; Process; Production; Proteins; RNase; RNase A; RNase I; Relative; Relative (related person); Ribonuclease A; Ribonuclease Family Protein; Ribonuclease I; Ribonucleases; S cerevisiae; Saccharomyces cerevisiae; Saccharomycetales; Severities; Source; Technology; Testing; Time; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Uncertainty; Variant; Variation; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; base; copy number variation; cost; disease prevention; disorder prevention; doubt; experience; experiment; experimental research; experimental study; fitness; functional genomics; gene function; gene product; genetic disorder; genome mutation; genome-wide; hereditary disorder; human data; human disease; improved; innovate; innovation; innovative; insight; living system; novel; paralog; paralogous gene; protein function; protein protein interaction; public health relevance; research study; sample fixation; theories; wasting",Functional genomic approaches to duplicate gene evolution," NARRATIVE ON PROJECT RELEVANCE Our projects will increase understanding of mechanisms of gene evolution and aid many studies of how new biological functions arise. Our study is of human health relevance, because many gene copy number variations, generated by gene duplication, are involved in human diseases. Furthermore, different functional relationships among duplicate genes (e.g., completely redundant, partially overlapping, or distinctly different) would predict different consequences of mutations to the likelihood and severity of genetic diseases. A clear understanding of these relationships helps clarify the exact molecular basis of human diseases, a necessary step in the treatment and prevention of these diseases.",67030,ZRG1,Special Emphasis Panel,A2S1,6,139092,
7993718,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM067045-07S1,,NIGMS:109900;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"JIANG, JIN ;",2104229;,3R01GM067045,01/08/2010,12/31/2010,"Address; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; BTB Domain; BTB/POZ Domain; Binding; Binding (Molecular Function); Biochemical; Biological; Body Tissues; Brain; C-terminal; Cancer of Prostate; Cancers; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell membrane; Cells; Cellular Expansion; Cellular Growth; Collection; Complex; Cultured Cells; Cytoplasmic Membrane; Data; Deacetylase; Development; Diagnosis; Disease; Disorder; Drosophila; Drosophila genus; Dysmyelopoietic Syndromes; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Encephalon; Encephalons; Ensure; Erinaceidae; Eye; Eye Development; Eyeball; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; Family; Feedback; Figs; Figs - dietary; Fruit Fly, Drosophila; Gastrointestinal Tract, Pancreas; GeneHomolog; Genetic; Genetic Screening; Goals; Hedgehogs; Homolog; Homologous Gene; Homologue; Human; Human, General; Insecta; Insects; Intracellular Communication and Signaling; Invertebrates, Insects; Investigators; Kinases; Kinesin; Laboratories; Leukemia, Granulocytic; Lung; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Mediating; Modification; Molecular Genetic; Molecular Genetics; Molecular Interaction; Myelocytic Leukemia; Myelodysplastic Syndromes; Myelogenous Leukemia; Myeloid Leukemia; N-terminal; NH2-terminal; Nervous System, Brain; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Nuclear; Nuclear Translocation; Nucleus; Organism; PKA kinase; POZ Domain; Pancreas; Pancreatic; Pathway interactions; Pattern; Phosphorylation; Phosphotransferases; Plasma Membrane; Play; Process; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Protein Phosphorylation; Proteins; Proteolytic Clipping; Proteolytic Processing; Recruitment Activity; Regulation; Research Personnel; Researchers; Respiratory System, Lung; Role; Signal Transduction; Signal Transduction Systems; Signaling; Smoldering Leukemia; Structure; Testing; Therapeutic; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transphosphorylases; Ubiquitin-Protein Ligase E3; Variant; Variation; Whole Organism; Wing; Work; biological signal transduction; cell growth; cell transduction; cellular transduction; disease/disorder; eye morphogenesis; fruit fly; gene product; hedgehog signal transduction; hh signal transduction; human disease; imaginal disc; improved; inhibitor; inhibitor/antagonist; insight; living system; loss of function; malignancy; model organism; mutant; myelodysplasia; myeloid granulocytic leukemia; myelosis; neoplasm/cancer; novel; ocular development; pathway; plasmalemma; prevent; preventing; programs; protein complex; protein kinase A kinase; pulmonary; recruit; response; scaffold; scaffolding; social role; tool; transduced cells; ubiquitin ligase; ubiquitin-protein ligase",Complex regulation of Ci/Gli proteins in Hedgehog signal transduction,,67045,DEV1,Development - 1 Study Section,S1,7,109900,
7993800,R01,GM,3,Y,01/15/2010,12/31/2010,PA-07-070,3R01GM067268-06S1,,NIGMS:91100;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,ANATOMY/CELL BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"VILLENEUVE, ANNE M;",1932402;,3R01GM067268,01/15/2010,12/31/2010,"Affect; Analysis, Data; Aneuploid; Aneuploidy; Architecture; Assay; Bioassay; Biologic Assays; Biological Assay; Birth Defects; Bloom Syndrome; Bloom-Torre-Machacek Syndrome; C elegans; C.elegans; Caenorhabditis elegans; Causality; Chiasma; Chiasma Opticum; Chromatin; Chromosomal Instability; Chromosome Instability; Chromosome Pairing; Chromosome Segregation; Chromosomes; Competence; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Congenital Telangiectatic Erythema Syndrome; Crossing Over; Crossing Over, Genetic; DNA; DNA Double Strand Break; DNA Recombination; DNA recombination (naturally occurring); Data; Data Analyses; Deoxyribonucleic Acid; Development; Dissociation; Engineering / Architecture; Ensure; Etiology; Event; FLR; Failure (biologic function); Gametes; Gene Conversion; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Crossing Over; Genetic Diseases, Inborn; Genetic Nondisjunction; Genetic Recombination; Genetic defect; Genome; Genome Instability; Genomic Instability; Germ Cells; Germ-Line Cells; Goals; Health; Histones; Homolog; Homologous Gene; Homologue; Human; Human, General; Imagery; In Vitro; Inborn Genetic Diseases; Inherited disorder; Lead; Light; Location; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Meiosis; Meiotic Recombination; Methods; Miscarriage; Modification; Molecular; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Mutation; Nematoda; Nematodes; Non-Disjunction, Genetic; Nondisjunction, Genetic; Optic Chiasm; Optic Chiasma; Optic Chiasmas; Optic Decussation; Organism; Outcome; Pathway interactions; Patients; Pb element; Phase; Phosphorylation Site; Photometry/Spectrum Analysis, Mass; Photoradiation; Predisposition; Process; Programs (PT); Programs [Publication Type]; Prophase; Proteins; Racial Segregation; Recombination; Recombination, Genetic; Regulation; Reproductive Cells; Research; Role; Sex Cell; Sister Chromatid; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spontaneous abortion; Staging; Structure; Susceptibility; Synapsis; Synapsis, Chromosomal; System; System, LOINC Axis 4; Testing; Time; Visualization; Work; cancer progression; cancer type; chromatin modification; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; failure; gene product; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; inborn error; initial cell; insight; living system; meiotic; mutant; neoplasm progression; neoplastic progression; nondisjunction; nonsister chromatid exchange; pathway; programs; public health relevance; repair; repaired; roundworm; segregation; sexual cell; social role; spatial relationship; tumor progression",Genetic Recombination in C.elegans,,67268,MGC,Molecular Genetics C Study Section,S1,6,91100,
7993825,R01,GM,3,Y,01/08/2010,12/31/2010,PA-98-074,3R01GM067841-05S1,,NIGMS:100651;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IOWA CITY,UNITED STATES,ANATOMY/CELL BIOLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"CORNELL, ROBERT AARON;",7760652;,3R01GM067841,01/08/2010,12/31/2010,"AP-2; AP-2 Alpha; AP-2 Alpha Gene; AP-2 Alpha Protein; AP2; AP2 Gene; AP2 Protein; AP2 Transcription Factor; AP2TF; AP2TF Protein; Activating Enhancer-Binding Protein 2-Alpha; Activator Protein 2; Activator Protein 2 Gene; Afferent Neurons; Alleles; Allelomorphs; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antimorphic mutation; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Apoptotic; Appearance; Body Tissues; Brachydanio rerio; CD117 Antigens; Cancer Drug; Cancers; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cell-Death Protease; Cessation of life; Chemotherapeutic Agents, Neoplastic Disease; Chromosome 18; Chromosomes, Human, Pair 18; Danio rerio; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Electron Microscopy; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Enhancers; Family member; Future; Genes; Genetic; Genetics-Mutagenesis; Grant; Head; ICE-like protease; InAs; Investigators; Learning; MITF protein; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Maps; Mast Cell Growth Factor Receptor; Melanophores; Methods; Mice, Mutant Strains; Modeling; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Mutant Strains Mice; Necrosis; Necrotic; Nerve Cells; Nerve Unit; Neural Cell; Neural Crest; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neurons, Afferent; Neurons, Sensory; PTK Receptors; Pathway interactions; Phenotype; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proto-Oncogene Protein c-kit; RTK; Reagent; Receptor Protein-Tyrosine Kinases; Regulatory Pathway; Research Personnel; Researchers; Resistance; Role; SCF Receptor; Sensory Cell Afferent Neuron; Specific qualifier value; Specified; Spinal; Stem Cell Factor Receptor; TFAP2; TFAP2 Protein; TFAP2A; TFAP2A Protein; TFAP2A gene; TFAP2alpha protein; Testing; Therapeutic; Tissues; Transcription Factor AP-2 Alpha; Transmembrane Receptor Protein Tyrosine Kinase; Tumor-Specific Treatment Agents; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Variant; Variation; Zebra Danio; Zebra Fish; Zebrafish; activator protein AP-2; anticancer agent; anticancer drug; c kit; c-kit Protein; c-kit Receptor; caspase; cell type; cystein protease; cystein proteinase; cysteine endopeptidase; disease/disorder; enhancer-binding protein AP-2; experiment; experimental research; experimental study; gene function; gene product; indium arsenide; insight; interest; kit Proto-Oncogene Protein; malignancy; melanocyte; melanoma; microphthalmia-associated transcription factor; mouse mutant; mutant; necrocytosis; neoplasm/cancer; neurodegenerative illness; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; new diagnostics; next generation diagnostics; novel; novel diagnostics; p145(c-kit); p145c-kit; pathway; positional cloning; premature; prevent; preventing; research study; resistant; reverse genetics; social role; transcription factor; transcription factor AP-2; transcription factor AP-2 alpha protein; transcription factor AP-2alpha; transcription factor AP2; transcription factor Microphthalmia",Pathways governing survival of neural crest derivatives,,67841,DEV,Development - 1 Study Section,S1,5,100651,
8008955,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM068095-05A1S1,,NIGMS:110244;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BROOKLYN,UNITED STATES,PHYSIOLOGY,11,040796328,US,NY,11203,SUNY DOWNSTATE MEDICAL CENTER,"HSU, ELLEN ;",1870163;,3R01GM068095,01/28/2010,12/31/2010,"AICDA; AICDA protein; Alleles; Allelomorphs; Antibody Diversity; Antigen Receptors; Autoimmune Status; Autoimmunity; Award; B blood cells; B-Cells; B-Lymphocytes; Biological Models; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CDA2 protein; Cell surface; Cells; Class Switching; Complementary DNA; Constant Region; Constant Region, Ig; DNA; DNA Sequence Rearrangement; DNA, Complementary; Data; Deoxyribonucleic Acid; Disease; Disorder; Ensure; Enzymes; Event; Exclusion; Feedback; Frequencies (time pattern); Frequency; Gamma Globulin, 19S; Gene Expression; Gene Organization; Gene Structure; Gene Structure/Organization; Gene Targeting; Genes; Genes, Ig; Genes, Immunoglobulin; Genetic; Genomics; Hand; Ig Somatic Hypermutation; IgM; Immune Globulins; Immune system; Immunization; Immunoglobulin Class Switching; Immunoglobulin Constant Region; Immunoglobulin Genes; Immunoglobulin Isotype-Switch Recombination; Immunoglobulin M; Immunoglobulin Somatic Hypermutation; Immunoglobulin Switch Recombination; Immunoglobulin V(D)J Rearrangement; Immunoglobulins; Immunoglobulins / Antibodies; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Isotype Switching; J segment gene; Jaw; Lesion; Light; Longitudinal Studies; Lymphocyte; Lymphocytic; M Phase; M phase (cell cycle); Malignant lymphoid neoplasm; Mammalia; Mammals; Mammals, General; Mitosis; Mitosis Stage; Model System; Models, Biologic; Models, Nursing; Mutate; Nature; Nurses; Nursing Models; Pathogenesis; Personnel, Nursing; Photoradiation; Point Mutation; Process; Rearrangement; Receptor Protein; Receptors, Antigen; Regulatory Pathway; Research; Resolution; Secure; Sensitization, Immunologic; Sensitization, Immunological; Shark - fish; Sharks; Somatic Hypermutation, Immunoglobulin; Staging; Stretching; Switch Recombination; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; System; System, LOINC Axis 4; Targetings, Gene; Time; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; Vertebrate Animals; Vertebrates; activation-induced cytidine deaminase; activation-induced deaminase; base; body system, allergic/immunologic; cDNA; disease/disorder; experiment; experimental research; experimental study; insight; long-term study; lymph cell; lymphoid malignancy; mutant; novel; organ system, allergic/immunologic; pathogen; public health relevance; receptor; recombinase; repair; repaired; research study; self recognition (immune); somatic hypermutation; vertebrata",Immunoglobulin Constant Region Switch and Hypermutation in the Nurse Shark,  Our shark model system carries about 85 immunoglobulin genes that are targeted by enzymes introducing nicks or lesions in the course of generating antibody diversity. We have observed genetic exchange taking place between the distantly located loci. Studying these phenomena will help determine parameters for genetic exchange between non-allelic genes and give insight into the origins of somatic translocation events leading to disease states.,68095,CMIB,Cellular and Molecular Immunology - B Study Section,A1S1,5,110244,
7993926,R01,GM,3,Y,01/15/2010,12/31/2010,PA-07-070,3R01GM068097-06A1S1,,NIGMS:95263;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CHUNG, CHANG Y;",7147216;,3R01GM068097,01/15/2010,12/31/2010,"ATPase, Actin-Activated; Actins; Adenosine Triphosphatase, Myosin; Affect; Applications Grants; Arthritis; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Function; Biological Process; Cancers; Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester; Cell Locomotion; Cell Migration; Cell Movement; Cell Polarity; Cells; Cellular Matrix; Cellular Migration; Chemicals; Chemoattractants; Chemotactic Factors; Chemotaxins; Chemotaxis; Complex; Cues; Cytoskeletal System; Cytoskeleton; Data; Defect; Dictyostelium; Disease; Disorder; Eukaryote; Eukaryotic Cell; F-Actin; Filamentous Actin; Genetic Alteration; Genetic Change; Genetic defect; Goals; Golgi; Golgi Apparatus; Golgi Complex; Grant Proposals; Grants, Applications; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Kinesin; Life; Ligands; Lymphocytes, Null; MS (Multiple Sclerosis); Malignant Neoplasms; Malignant Tumor; Membrane; Micro-tubule; Microtubules; Molecular; Molecular Interaction; Motility; Motility, Cellular; Movement; Multiple Sclerosis; Mutation; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Nocodazole; Null Cells; Null Lymphocytes; Oncodazole; Play; Position; Positioning Attribute; Process; Protein Family; Proteins; Proteomics; Regulation; Research; Role; Sclerosis, Disseminated; Secretory Granules; Secretory Vesicles; Signal Transduction Pathway; Sorting - Cell Movement; Stream; Testing; VESCL; Vesicle; Wound Healing; Wound Repair; arthritic; axonal guidance; body movement; cell cortex; cell imaging; cell motility; cellular imaging; cellular polarity; complement chemotactic factor; directional cell; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; insight; insular sclerosis; intracellular skeleton; malignancy; membrane structure; mutant; myosin ATP phosphohydrolase (actin translocating); neoplasm/cancer; nervous system development; public health relevance; receptor binding; research study; response; social role; sorting; tissue repair; trafficking",Spatial Regulation of Cytoskeleton During Chemotaxis," Project Narrative Many cells in our body undergo chemotaxis, directed movement toward a chemical compound which is necessary for many biological functions including wound healing and the development of the nervous system. Chemotaxis also plays a role in disease states such as arthritis, cancer, and multiple sclerosis. Our proposed research would help us understand how cells maintain cell polarity and directed cell movement when they migrate directionally toward a directional cue.",68097,CSF,Cell Structure and Function Study Section,A1S1,6,95263,
8011916,R01,GM,3,Y,02/05/2010,01/31/2011,,3R01GM068433-07S1,,NIGMS:92046;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,CHEMISTRY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"YAMAMOTO, HISASHI NONE;",7332224;,3R01GM068433,02/05/2010,01/31/2011,"3-hydroxybutanal; 3-hydroxybutyraldehyde; Academia; Acids; Alcohols; Alder; Alder plant; Alnus; Area; Attention; C element; Carbon; Catalysis; Chemical Class, Alcohol; Chemistry; Chemistry, Pharmaceutical; Complex; Data; Development; Diels Alder reaction; Drug Industry; Drugs; Employment; Ethers; Future; Generalized Growth; Goals; Grant; Group 17 Elements; Growth; Halogens; Health Care Costs; Health Costs; Healthcare Costs; Human; Human, General; Industry; Industry, Pharmaceutic; Investigators; Kinetic; Kinetics; Knowledge; Laboratories; Libraries; Ligands; Man (Taxonomy); Man, Modern; Medication; Medicinal Chemistry; Method LOINC Axis 6; Methodology; Methods; Molecular; N element; N2 element; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nitrogen; Nitroso Compounds; O element; O2 element; Organic Synthesis; Outcome; Oxygen; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Industry; Pharmaceutical Preparations; Process; Production; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Reaction; Reagent; Research; Research Personnel; Researchers; Resolution; S element; Sales; Science; Science of Chemistry; Social Welfare; Societies; Solutions; Sulfur; System; System, LOINC Axis 4; Technology; Testing; Tissue Growth; Training; United States National Institutes of Health; V element; Vanadium; acetaldol; aldol; career; catalyst; chiral molecule; cycloaddition; design; designing; drug development; drug/agent; enol; experience; functional group; graduate student; halogenation; innovate; innovation; innovative; novel; ontogeny; oxidation; programs; public health medicine (field); pyridine; success; tool; trend; wasting; welfare",Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules,,68433,SBCB,Synthetic and Biological Chemistry B Study Section,S1,7,92046,
8000124,R01,GM,3,Y,01/29/2010,12/31/2010,,3R01GM068595-07S1,,NIGMS:90284;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GUNDERSEN, GREGG G;",1898358;,3R01GM068595,01/29/2010,12/31/2010,"Actins; Adaptor Protein; Adaptor Signaling Protein; Adhesion Plaques; Adhesions; Adhesives; Affect; Antimorphic mutation; Arts; Assay; Back; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; CG-1 protein; Cell Locomotion; Cell Migration; Cell Movement; Cell surface; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cells; Cellular Matrix; Cellular Migration; Clathrin; Clathrin Adaptors; Clathrin Assembly Proteins; Clathrin-Associated Adaptors; Clathrin-Associated Proteins; Coated vesicle; Cytoplasmic Domain; Cytoplasmic Tail; Cytoskeletal System; Cytoskeleton; Data; Dependence; Dephosphin; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Dynamin; ECM; ECM receptor; Endocytosis; Extracellular Matrix; Extracellular Matrix, Integrins; FAK; FAK1; Focal Adhesion Kinase 1; Focal Adhesions; Focal Contacts; Goals; Growing End of the Microtubule; INFLM; Inflammation; Integrins; KTN1 protein; Kinesin; Learning; Ligand Binding Protein; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Micro-tubule; Microtubules; Motility; Motility, Cellular; Motor; Neoplasm Metastasis; PTK2; PTK2 Protein Tyrosine Kinase 2; Participant; Pathway interactions; Play; Plus End of the Microtubule; Process; Proteins; RNA, Small Interfering; Receptor Protein; Recycling; Residencies; Role; Secondary Neoplasm; Secondary Tumor; Site; Small Interfering RNA; Structure; System; System, LOINC Axis 4; Testing; Time; Traction; Tumor Cell Migration; Wound Healing; Wound Repair; adhesion receptor; cancer metastasis; cell motility; cell type; endogenous substrate pp120; experiment; experimental research; experimental study; extracellular matrix receptor; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; gene product; intracellular skeleton; kinectin; kinectin1 protein; membrane structure; migration; novel; p125(FAK); p125FAK; pathway; pp125(FAK); pp125FAK; receptor; research study; residence; siRNA; social role; tissue repair",Mechanisms of Integrin-microtubule cross-talk,,68595,CSF,Cell Structure and Function Study Section,S1,7,90284,
8000130,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM068756-06A1S1,,NIGMS:95738;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TALLAHASSEE,UNITED STATES,OTHER BASIC SCIENCES,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"MEGRAW, TIMOTHY L;",1978059;,3R01GM068756,01/29/2010,12/31/2010,"21+ years old; Actins; Adult; Affect; Aneuploid; Aneuploidy; Animals; Auras; Binding; Binding (Molecular Function); Binding Sites; Biochemistry; Biological Models; Body Size; Brain; Cancers; Categories; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Signaling; Cell division; Cells; Cellular biology; Centrioles; Centrosome; Chemistry, Biological; Chest; Chromosomal Instability; Chromosome Instability; Cilia; Combining Site; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; Deafness; Defect; Development; Developmental Process; Disease; Disorder; Drosophila; Drosophila genus; EC 2.7; Embryo; Embryonic; Encephalon; Encephalons; Family member; Flies; Foundations; Fruit Fly, Drosophila; Funding; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Homolog; Homologous Gene; Homologue; Human; Human, Adult; Human, General; Hydrocephalus; Hydrocephaly; Image; In Vitro; Intracellular Communication and Signaling; Job Environment; Job Location; Job Place; Job Setting; Job Site; Kinases; Kinetic; Kinetics; Label; Licensing; Life; Link; M Phase; M phase (cell cycle); MTOC; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measures; Messenger RNA; Mice; Mice, Mutant Strains; Micro-tubule; Microcephaly; Microtubule-Organizing Center; Microtubules; Mitosis; Mitosis Stage; Mitotic; Mitotic spindle; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Mutation; Nervous System, Brain; Neural Stem Cell; Obesity; Organ; Organelles; Organism-Level Process; Organismal Process; Ortholog; Orthologous Gene; Pathology; Pathway interactions; Phase; Phosphotransferases; Physiologic Processes; Physiological Processes; Plant Roots; Play; Polycystic Kidney; Polycystic Kidney Diseases; Polymerase; Predisposition; Probability; Process; Protein Family; Proteins; RNA, Messenger; Reactive Site; Recruitment Activity; Regulation; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Speed; Speed (motion); Spermatocytes; Spermiocytes; Structure; Susceptibility; Syndrome; System; System, LOINC Axis 4; Testing; Thorace; Thoracic; Thorax; Transphosphorylases; Vertebrate Biology; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; adiposity; adult human (21+); aurora-A kinase; auroraA kinase; basal body; base; biological signal transduction; cancer cell; cancer progression; cell biology; cohesion; corpulence; corpulency; corpulentia; disease/disorder; fly; fruit fly; gene function; gene product; genome mutation; human disease; imaging; in vivo; kinetosome; mRNA; malignancy; micrencephaly; microencephaly; mouse model; mouse mutant; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; novel; obese; obese people; obese person; obese population; pathway; pericentrin; polymerization; prevent; preventing; protein function; public health relevance; reconstitute; reconstitution; recruit; root; social role; tool; tumor progression; work environment; work setting",Centrosomin and centrosomes in cell division," Mutations in genes that function at centrioles and centrosomes cause a host of human disorders due to their importance in so many developmental and physiological processes. These ailments include polycystic kidney disease, deafness, hydrocephaly, obesity, microcephaly, and more. The goal of this proposal is to gain molecular and mechanistic understanding of centrioles and centrosomes, structures found in nearly every cell, in flies and mice and discern the pathology of autosomal recessive primary microcephaly (MCPH).",68756,NDT,Nuclear Dynamics and Transport,A1S1,6,95738,
8000135,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM068849-06S1,,NIGMS:80000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,CHEMISTRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"CHO, WONHWA ;",1887096;,3R01GM068849,01/29/2010,12/31/2010,"Abbreviations; Arts; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Membrane; Cellular Physiology; Cellular Process; Cellular Regulation; Complex; Computing Methodologies; Cytoplasmic Membrane; Defect; Development; Diabetes Mellitus; Disease; Disorder; Fluorescence Microscopy; Grant; Health; In Vitro; Inflammatory; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Learning; Ligand Binding Protein; Link; Lipid Binding; Malignant Neoplasms; Malignant Tumor; Mediating; Membrane; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular Interaction; Monitor; Pathway interactions; Penetration; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Plasma Membrane; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding Domain; Protein Binding Motif; Protein-Protein Interaction Domain; Proteins; PtdIns; Regulation; Research; Role; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stimulus; Subcellular Process; Techniques; Therapeutic Agents; Time; VESCL; Vesicle; base; biological signal transduction; cell growth regulation; cell imaging; cellular imaging; computational methodology; computational methods; computer methods; diabetes; disease/disorder; drug development; drug discovery; epsin; gene product; human disease; malignancy; membrane structure; neoplasm/cancer; pathway; plasmalemma; programs; protein activation; protein complex; public health relevance; response; screening; screenings; social role; tool; trafficking",Membrane Targeting by Phosphoinositide-Binding Proteins,,68849,ZRG1,Special Emphasis Panel,S1,6,80000,
7995595,R01,GM,3,Y,01/08/2010,08/31/2010,,3R01GM069680-04S2,,NIGMS:102334;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,OTHER BASIC SCIENCES,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"STASKAWICZ, BRIAN JOHN;",7614966;,3R01GM069680,01/08/2010,08/31/2010,"Achievement; Achievement Attainment; Affinity Chromatography; Algorithms; Amino Acids; Animals; Aquadiol; Arabidopsis; Arabidopsis RIN4 protein; Arabidopsis thaliana; Assay; Binding; Binding (Molecular Function); Bio-Informatics; Bioassay; Biochemical; Biochemical Genetics; Bioinformatics; Biologic Assays; Biological; Biological Assay; Biological Models; Cell Communication and Signaling; Cell Death; Cell Extracts; Cell Signaling; Cell membrane; Cells; Chromatography, Affinity; Chromatography, Exclusion; Chromatography, Gel; Chromatography, Gel Permeation; Cleaved cell; Co-Immunoprecipitations; Coupled; Cress, Mouse-ear; Cysteine Endopeptidases; Cysteine Protease; Cysteine Proteinases; Cytoplasmic Membrane; DISSEC; Data; Deletion Mutagenesis; Development; Dimenformon; Diogyn; Diogynets; Disease; Disease Resistance; Disorder; Dissection; Drosophila chb protein; Enzymes; Esteroproteases; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Event; Evolution; Fungal Genome; Gel Chromatography; Gel Filtration; Gel Filtration Chromatography; Generalized Growth; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Genome; Genome, Fungal; Goals; Growth; Host resistance; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Infection; Intracellular Communication and Signaling; Ion Exchange; Knock-out; Knockout; LRR protein; Laboratories; Lead; Libraries; MAST; MESR7 protein, Drosophila; Mass Spectrum; Mass Spectrum Analysis; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mouse-ear Cress; Mutation; N-terminal; NH2-terminal; Natural Immunity; Ovocyclin; Ovocylin; Pathology; Pathway interactions; Pb element; Peptidases; Peptide Domain; Peptide Hydrolases; Photometry/Spectrum Analysis, Mass; Plants; Plants, General; Plants, Higher; Plasma Membrane; Position; Positioning Attribute; Procedures; Process; Progynon; Proteases; Protein Cleavage; Protein Domains; Proteinases; Proteins; Proteolysis; Proteolytic Clipping; Proteolytic Enzymes; Proteolytic Processing; Pseudomonas syringae; RIN4 protein, Arabidopsis; RPM1-interacting protein 4, Arabidopsis; Recombinants; Regulation; Repression; Research; Resistance; Resistance, Disease; S cerevisiae; Saccharomyces cerevisiae; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Specific qualifier value; Specified; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; System; System, LOINC Axis 4; Tertiary Protein Structure; Testing; Therapeutic Estradiol; Thiol Protease; Tissue Growth; Tomatoes; Tracheophyta; Transgenic Organisms; Triad; Triad Acrylic Resin; Triad resin; Type III Secretion System; Type III Secretion System Pathway; Vascular Plant; Virulence; Yeast, Baker's; Yeast, Brewer's; Yeasts; affinity purification; aminoacid; assay development; base; biological signal transduction; body system, allergic/immunologic; chb protein, Drosophila; chromosome bows protein, Drosophila; cleaved; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; genome sequencing; heavy metal Pb; heavy metal lead; in vitro Assay; insight; leucine-rich repeat protein; mast protein, Drosophila; member; milligram; molecular recognition; multiple asters protein, Drosophila; necrocytosis; ontogeny; orbit protein, Drosophila; organ system, allergic/immunologic; pathogen; pathway; plasmalemma; protein complex; research study; resistance to disease; resistant; resistant disease; resistant to disease; response; transgenic; yeast genome",Molecular Basis of Arabidopsis Innate Immunity,,69680,CDF,Cell Development and Function Integrated Review Group,S2,4,102334,
7995625,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM070539-06S1,,NIGMS:85598;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"TOCZYSKI, DAVID P;",1871671;,3R01GM070539,01/20/2010,12/31/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 2PP2A; APF-1; ATP-Dependent Proteolysis Factor 1; Adaptor Protein; Adaptor Signaling Protein; Alleles; Allelomorphs; Architecture; Bears; Binding; Binding (Molecular Function); Biochemistry; Biology; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Cycle; Cell Cycle Control; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Function; Cell Process; Cell division; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Characteristics; Chemistry, Biological; Chimera Protein; Chimeric Proteins; Chromosomes; Complex; D-Glucose; Data; Dextrose; Docking; EC 2.7; Engineering / Architecture; Enzymatic Biochemistry; Enzymes; Enzymology; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; Fusion Protein; GWAS; Gene Transcription; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Glucose; Glycogen Synthase Kinases; Goals; HLA-DR Associated Protein II; HMG-20; High Mobility Protein 20; I2PP2A; IGAAD; In Vitro; Inhibitor of GZMA-Activated DNase; Kinases; Libraries; Life; Ligase; Macropain; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microscopy; Modeling; Molecular Interaction; Multicatalytic Proteinase; Mutation; Names; Nature; Nutrient; PHAPII; Pathway interactions; Phenotype; Phosphatase 2A Inhibitor I2PP2A; Phosphoproteins; Phosphotransferases; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Turnover; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; Proteosome; RNA Expression; Receptor Protein; Regulation; Role; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Screening procedure; Series; Set protein; Signal Pathway; Specificity; Structure; Subcellular Process; Substrate Specificity; Synthetases; System; System, LOINC Axis 4; TAF-IBETA; Techniques; Template Activating Factor I Beta; Testing; Transcription; Transcription, Genetic; Transphosphorylases; Ubiquitilation; Ubiquitin; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; Ubiquitination; Ubiquitinoylation; Ursidae; Ursidae Family; Yeasts; c myc; c-myc Genes; cell biology; deprivation; detection of nutrient; dimer; experiment; experimental research; experimental study; gene product; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; in vivo; malignancy; multicatalytic endopeptidase complex; neoplasm/cancer; novel; nutrient sensing; pathway; perception of nutrients; protein degradation; public health relevance; receptor; research study; response; screening; screenings; social role; transcription factor; tumor; ubiquination; ubiquitin conjugation; ubiquitin ligase; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; whole genome association studies; whole genome association study",Cell cycle regulation by ubiquitin ligases,,70539,CSRS,Cellular Signaling and Regulatory Systems Study Section,S1,6,85598,
8000155,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM070622-06S1,,NIGMS:80000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLLEGE STATION,UNITED STATES,CHEMISTRY,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"CREMER, PAUL ;",1977734;,3R01GM070622,01/29/2010,12/31/2010,"2-dimensional; ANXA5; ATP phosphohydrolase; ATPase; Acrylamides; Adenosine Triphosphatase; Adenosinetriphosphatase; Agarose; Anchorin CII; Annexin A5 Protein; Annexin V; Antibodies; Architecture; Arts; Assay; Attention; Bioassay; Biologic Assays; Biological Assay; Blood Clot; Blood Clotting; Blood coagulation; Buffers; CBP-I; Caliber; Calphobindin I; Cells; Cellular Membrane; Cellulose; Charge; Chemistry; Diameter; Dimensions; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E coli; E coli inner membrane protein; Electrodes; Electrolyses; Electrolysis; Electrophoresis; Endonexin II; Engineering / Architecture; Ensure; Environment; Escherichia coli; Film; Fractionation, Electrophoretic; Gel; Genome; Glass; Goals; Heating; Hemalysins; Hemolysin; Hydrogen Oxide; Integral Membrane Protein; Intrinsic Membrane Protein; Ion Channel; Ionic Channels; Ions; Lipid Bilayers; Lipid Rafts, Cell Membrane; Lipids; Lipocortin-V; Liposomal; Liposomes; Liquid substance; Measurement; Measures; Membrane; Membrane Channels; Membrane Microdomains; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; ORFs; Open Reading Frames; Organism; PAP-I; PP4; Pattern; Peripheral; Periplasmic Space; Phosphatides; Phospholipids; Placental Anticoagulant Protein I; Placental Protein 4; Polyanhydroglucuronic Acid; Polymers; Pore Proteins; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Procedures; Process; Property; Property, LOINC Axis 2; Protein Coding Region; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein translocation; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteins, Pore; Proteomics; Relative; Relative (related person); Resolution; Rest; Science of Chemistry; Sepharose; Side; Solid; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; Surface; Surface Proteins; Techniques; Temperature; Testing; Thromboplastin Inhibitor; Transmembrane Protein; Transmembrane Protein Transport; V (voltage); VAC-Alpha; VESCL; Vascular Anticoagulant-Alpha; Vesicle; Water; Work; alpha-Cellulose; annexin A5; design; designing; fluid; fluidity; gene product; inner membrane protein, E coli; lipid bilayer membrane; lipid raft; liquid; living system; membrane structure; nano pore; nanopore; novel; periplasm; periplasmic; prevent; preventing; protein aggregation; public health relevance; two-dimensional; voltage",Creating Platforms for the Proteomics and Membrane Proteins," Project Narrative  It is generally believed that 15 to 30% of open reading frames in the genomes of most organisms encode membrane proteins. Moreover, 2 out of 3 drug targets are proteins embedded in cellular membranes. It is therefore vital to develop chromatographic assays to identify these species, their expression levels, as well as follow posttranslational modifications.",70622,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,S1,6,80000,
8007533,R01,GM,3,,07/01/2009,06/30/2010,,3R01GM070862-05S1,,NIGMS:24820;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,ANATOMY/CELL BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"VERHEY, KRISTEN J;",1905030;,3R01GM070862,07/01/2005,06/30/2010,"Acetylation; Address; Adenosine Triphosphatase, Dynein; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Carrier Proteins; Cell Body; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell division; Cells; Cellular Matrix; Cellular Migration; Chromosomes; Complex; Cytoplasm; Cytoskeletal System; Cytoskeleton; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Destinations; Development; Disease; Disorder; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Embryo; Embryonic; FRET; Fasciculation; Fasciculation, Muscular; Fasciculation, Neural; Fluorescence Resonance Energy Transfer; Genetic; Goals; Growing End of the Microtubule; Human; Human, General; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Vitro; Intracellular Communication and Signaling; Intracellular Transport; Investigators; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; Kinesin; Light; Lipids; Locales; Locomotor Activity; MAP Kinase 8; MAPK8 Mitogen-Activated Protein Kinase; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Micro-tubule; Microtubules; Minus End of the Microtubule; Mitogen-Activated Protein Kinase 8; Modeling; Modification; Molecular; Molecular Interaction; Molecular Motors; Motility; Motility, Cellular; Motor; Motor Activity; Movement; Muscle fasciculation; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurites; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Nongrowing End of the Microtubule; Organism; Phenotype; Phosphorylation; Photoradiation; Play; Plus End of the Microtubule; Polycystic Kidney; Polycystic Kidney Diseases; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Programs (PT); Programs [Publication Type]; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Trafficking; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA, Messenger; Regulation; Research; Research Personnel; Researchers; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Scaffolding Protein; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Tail; Testing; Tetrahymena; Traffickings, Protein; Transport Proteins; Transport Vesicles; Transporter Protein; Work; base; biological signal transduction; body movement; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cell body (neuron); cell motility; disease/disorder; dynein ATP phosphohydrolase (tubulin translocating); experiment; experimental research; experimental study; gene product; human disease; in vivo; inhibitor; inhibitor/antagonist; insight; intracellular skeleton; jun-NH2-Terminal Kinase; living system; mRNA; malignancy; neoplasm/cancer; neural cell body; neurodegenerative illness; neuronal; neuronal cell body; programs; protein complex; protein function; protein transport; research study; social role; soma; stress-activated protein kinase 1; therapeutic target; trafficking",Regulation of the molecular motor kinesin-I,,70862,CSF,Cell Structure and Function Study Section,S1,5,24820,
7995689,R01,GM,3,Y,01/29/2010,12/31/2010,,3R01GM070892-04S1,,NIGMS:149562;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,GENETICS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"MATTOX, WILLIAM W;",1902312;,3R01GM070892,01/29/2010,12/31/2010,"Affect; Alternate Splicing; Alternative Splicing; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Body Tissues; CD44; CD44 gene; Cell Communication and Signaling; Cell Signaling; Characteristics; Combining Site; Complex; Development; Disease; Disorder; Drosophila; Drosophila genus; Elements; Enhancers; Family; Feedback; Flies; Fruit Fly, Drosophila; Gene Products, RNA; Genes; Genetic; Genome, Human; Human; Human Genome; Human, General; In Vitro; In element; Indium; Individual; Intervening Sequences; Intracellular Communication and Signaling; Introns; Investigators; Knowledge; MDU3; MT-bound tau; Man (Taxonomy); Man, Modern; Model System; Modeling; Models, Biologic; Molecular Interaction; Nuclear Extract; ORFs; Open Reading Frames; Organism; Pattern; Pgp1; Play; Position; Positioning Attribute; Pre-mRNA; Process; Programs (PT); Programs [Publication Type]; Protein Coding Region; Protein Family; Proteins; RNA; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA Sequences; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA-Binding Proteins; Reactive Site; Recombinants; Regulation; Regulatory Element; RegulatoryElement; Repression; Research Personnel; Researchers; Ribonucleic Acid; Role; Sequences, RNA; Signal Transduction; Signal Transduction Systems; Signaling; Site; Splicing; Staging; System; System, LOINC Axis 4; Testing; Tissues; Transcript; Transgenic Organisms; Upstream Enhancer; biological signal transduction; cell type; cofactor; disease/disorder; experiment; experimental research; experimental study; fly; fruit fly; gene product; in vitro Assay; in vivo; information gathering; living system; mRNA Precursor; male; member; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; premRNA; programs; protein function; research study; social role; tau; tau Proteins; tau factor; transgenic",Positive and Negative control of pre-mRNA processing,,70892,CDF,Cell Development and Function Integrated Review Group,S1,4,149562,
7995717,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM072089-05A2S2,,NIGMS:37871;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,BIOCHEMISTRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"KREUZER, KENNETH N;",1898149;,3R01GM072089,01/20/2010,12/31/2010,"10Sa RNA; 2(1H)-Pyrimidinone, 4-amino-; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5-AC; 5-Aza-cytidine; 5-Azacytidine; AZC; Active Follow-up; Affect; After Care; After-Treatment; Aftercare; Allergy; Anti-Bacterial Agents; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Azacitidine; Azacytidine; Bacterial DNA; Binding; Binding (Molecular Function); Biochemical; Biological Models; Blood (Leukemia); CDR; Cancer Drug; Cancers; Cell Extracts; Cells; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Chromosome 5; Chromosomes, Human, Pair 5; Ciprofloxacin; Collection; Combination Chemotherapy Regimen; Complex; Coupled; Cytidine, 2'-deoxy-; Cytosine; Cytosine Deoxyribonucleoside; Cytosine Deoxyriboside; DNA; DNA Damage; DNA Damage Repair; DNA Gyrase; DNA Helicases; DNA Injury; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA Polymerase III; DNA Polymerase delta; DNA Repair; DNA Sequence; DNA Unwinding Proteins; DNA unwinding enzyme; DNA, Bacterial; DNA-Binding Proteins; DNA-Dependent DNA Polymerase III; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; DNA-Methyltransferases; DNA-protein crosslink; Defect; Deoxycytidine; Deoxyribonucleic Acid; Dnmt; Drugs; E coli; EC 2.1.1; EC 2.1.1.113; EC 2.7.7.6; Enzymes; Escherichia coli; Exonuclease; FLR; Failure (biologic function); Formaldehyde; Formic Aldehyde; Gene Products, RNA; Gene Transcription; Genes; Genetic Transcription; Genetic analyses; Genome Instability; Genomic Instability; Goals; Hand; Hypersensitivity; In Vitro; Ketoquinolines; L-tyrosine, dihydrogen phosphate (ester); Lead; Lesion; Leukemias, General; Lytotoxicity; Malignant Neoplasms; Malignant Tumor; Measures; Medication; Methanal; Methyl Aldehyde; Methyltransferase; Miscellaneous Antibiotic; Model System; Modeling; Models, Biologic; Modification Methylases; Molecular Interaction; Nature; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Oligo; Oligonucleotides; Oxomethane; Oxoquinolines; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotyrosine; Pol III; Prevalence; Process; Proteins; Public Health; Quality Control; Quimioterapia; Quinolinones; Quinolone Antibiotic; Quinolones; RNA; RNA Expression; RNA Polymerases; RNA, Non-Polyadenylated; Radiation; Reaction; Research; Ribonucleic Acid; Ribosomes; Role; Scientist; Site; Site-Specific DNA-methyltransferase; Syndrome; System; System, LOINC Axis 4; Testing; Training; Transcription; Transcription, Genetic; Translating; Translatings; Translations; Tumor-Specific Treatment Agents; Tyrosine-O-phosphate; Unscheduled DNA Synthesis; Work; analog; anti-bacterial; antibacterial; anticancer agent; anticancer drug; base; cancer chemotherapy; chemotherapeutic agent; cross-link; crosslink; cytotoxicity; design; designing; drug/agent; experiment; experimental research; experimental study; failure; follow-up; gene product; genetic analysis; heavy metal Pb; heavy metal lead; helicase; improved; in vivo; inhibitor; inhibitor/antagonist; interest; ladakamycin; language translation; leukemia; malignancy; methyl group; methylase; mutant; neoplasm/cancer; nuclease; pathway; public health medicine (field); public health relevance; ray (radiation); repair; repaired; research study; response; social role; ssrA gene product; tmRNA; transmethylase",Processing and consequences of DNA-protein crosslinks in E. coli," Relevance Statement This research is relevant to public health because understanding how chemotherapeutic agents work can help scientists and clinicians improve therapy with the drugs. Two important chemotherapeutic agents are studied here: the quinolones, which are among the most frequently prescribed antibiotics (including the commonly used ciprofloxacin), and 5- azacytidine, which is effective in cancer chemotherapy against leukemia and pre-leukemia syndromes. In addition, the pathways of replication fork failure and the repair of DNA- protein crosslinks are issues relevant to the genome instability that can lead to the formation of cancers.",72089,ZRG1,Special Emphasis Panel,A2S2,5,37871,
8009768,R01,GM,3,Y,01/21/2010,07/31/2010,,3R01GM072551-05S1,,NIGMS:39809;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,GENETICS,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"COLAIACOVO, MONICA P;",1935908;,3R01GM072551,01/21/2010,07/31/2010,"3-D; 3-Dimensional; Address; Antibodies; Architecture; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Birth Defects; C elegans; C.elegans; Caenorhabditis elegans; Candidate Disease Gene; Candidate Gene; Cell Division Process; Chiasma; Chiasma Opticum; Chromosome 3; Chromosome Condensation; Chromosome Pairing; Chromosome Segregation; Chromosomes; Chromosomes, Human, Pair 3; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Coupled; DNA Recombination; DNA recombination (naturally occurring); Down Syndrome; Down's Syndrome; Downs Syndrome; Electron Microscopy; Embryo; Embryonic; Engineering / Architecture; Event; Gametes; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Nondisjunction; Genetic Recombination; Genetic defect; Germ Cells; Germ-Line Cells; Haploid; Haploidy; Homolog; Homologous Gene; Homologue; Human; Human, General; Immunoelectron Microscopy; Impairment; Investigators; Japan; Laboratories; Langdon Down syndrome; Lead; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Meiosis; Meiotic Recombination; Methods; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Miscarriage; Molecular; Molecular Genetic Abnormality; Mongolism; Monitor; Morphology; Mutation; Nematoda; Nematodes; Non-Disjunction, Genetic; Nondisjunction, Genetic; Nuclear; Optic Chiasm; Optic Chiasma; Optic Chiasmas; Optic Decussation; Pattern; Pb element; Phase; Preparation; Programs (PT); Programs [Publication Type]; Prophase; Proteins; Recombination; Recombination, Genetic; Regulation; Reproduction; Reproductive Cells; Research Personnel; Researchers; Role; Series; Sex Cell; Spontaneous abortion; Squash (Food); Squashes; Staging; Staining method; Stainings; Stains; Structure; Synapsis; Synapsis, Chromosomal; Synaptonemal Complex; System; System, LOINC Axis 4; Trisomy 21; Yeasts; chromosome 21 trisomy syndrome; congenital acromicria syndrome; deletion library; experiment; experimental research; experimental study; functional genomics; gene product; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; initial cell; knockout gene; knowledge base; macromolecular assembly; meiotic; morbus Down; mutant; nondisjunction; programs; pseudohypertrophic progressive muscular dystrophy; research study; roundworm; sexual cell; social role; tool; trisomy 21 syndrome",Synaptonemal complex assembly and function in meiosis,,72551,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",S1,5,39809,
7995813,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM072562-04S3,,NIGMS:119668;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TALLAHASSEE,UNITED STATES,BIOLOGY,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"DENG, WU-MIN ;",7698531;,3R01GM072562,01/20/2010,12/31/2010,"21+ years old; Adopted; Adult; Anterior; Back; Cell Communication; Cell Communication and Signaling; Cell Death; Cell Function; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Polarity; Cell Process; Cell Signaling; Cell division; Cell physiology; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-Extracellular Matrix; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Communication; Cranin; Cytoskeletal System; Cytoskeleton; Cytosolic Protein Tyrosine Phosphastase; Defect; Development; Developmental Cell Biology; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drosophila; Drosophila genus; Dystroglycan; Dystroglycans; ECM; ECM receptor; EGFR; ERBB Protein; ERBB1; Embryo; Embryonic; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Extracellular Matrix; Flies; Fruit Fly, Drosophila; Future; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glycoprotein GP-2; HER1; Human, Adult; Intracellular Communication and Signaling; Knowledge; Laminin; Ligands; Mediating; Micro-tubule; Microtubules; Motility; Motility, Cellular; Muscular Dystrophies; Mutation; Myodystrophica; Myodystrophy; Notch Signaling Pathway; Oocytes; Oogenesis; Ovocytes; PHEMX; PHEMX Protein; PHEMX protein, human; PTPase; Pan-Hematopoietic Expression Protein; Pathway interactions; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Play; Process; Protein Tyrosine Phosphatase; Proteolysis and Signaling Pathway of Notch; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Research; Research Design; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Study Type; Subcellular Process; Substrate Interaction; TSSC6; TSSC6 protein, human; Testing; Tetraspanin; Time; Transforming Growth Factor alpha Receptor; Tumor-Suppressing STF 6 Protein; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Work; adult human (21+); base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cell motility; cell type; cellular polarity; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; extracellular matrix receptor; fascinate; fly; fruit fly; genome mutation; human PHEMX protein; insight; intercellular communication; intracellular skeleton; necrocytosis; notch; notch protein; notch receptors; novel; pan-hematopoietic expression protein, human; pathway; protein tyrosine phosphate phosphohydrolase; proto-oncogene protein c-erbB-1; receptor; social role; study design; tumor suppressing subtransferable candidate 6 protein, human",Intercellular Communication and Oocyte Polarity,,72562,ZRG1,Special Emphasis Panel,S3,4,119668,
8008949,R01,GM,3,Y,01/28/2010,12/31/2010,,3R01GM072700-05S1,,NIGMS:201257;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,CHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"FRANCIS, MATTHEW B;",7936693;,3R01GM072700,01/28/2010,12/31/2010,"Address; Affinity Chromatography; Alder; Alder plant; Alkenes; Alkynes; Alnus; Antibody Fragments; Arts; Buffers; Catalysis; Chemicals; Chemistry, Organic; Chromatography, Affinity; Closure by Ligation; Complement; Complement Proteins; Coupling; Cysteine; DRTA; Development; Diels Alder reaction; Disulfides; Electrons; Future; Genetic Engineering of Proteins; Half-Cystine; Hour; Imines; Immobilization; Immunoglobulin Fragments; Investigators; L-Cysteine; L-Lysine; L-Methionine; L-Tyrosine; Label; Ligation; Link; Lysine; Mannich Bases; Membrane Proteins; Membrane-Associated Proteins; Metals; Methionine; Methionine, L-Isomer; Methods; Methods and Techniques; Methods, Other; Modification; N-terminal; NH2-terminal; Nature; Negative Beta Particle; Negatrons; Olefins; Organic Chemistry; Organic Synthesis; Oxidation-Reduction; Peptide Biosynthesis, Ribosomal; Phenazines; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Engineering; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Synthesis, Ribosomal; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Rain; Reaction; Redox; Research; Research Design; Research Personnel; Researchers; Rh element; Rh2(II)(acetate)4; Rh2(OAc)4; Rhodium; Screening procedure; Site; Study Type; Surface Proteins; TYR; Techniques; Transition Elements; Tyrosine; Tyrosine, L-isomer; adduct; affinity purification; aqueous; base; carbene; catalyst; design; designing; dirhodium tetraacetate; disulfide bond; fluorophore; functional group; gene product; iminoquinone; immobilization of body part; interdisciplinary approach; methylene; methylene radical; novel; orthopedic freezing; oxidation reduction reaction; para-Tyrosine; programs; protein expression; protein synthesis; screening; screenings; study design; tetra-mu-acetatodirhodium(II); transition metal",New Synthetic Strategies for Protein Engineering,,72700,BNP,Bio-Organic and Natural Products Chemistry Study Section,S1,5,201257,
8010514,R01,GM,3,Y,01/28/2010,12/31/2010,PA-02-110,3R01GM072778-05S1,,NIGMS:149061;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAINT LOUIS,UNITED STATES,PHYSIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"TRUE-KROB, HEATHER L;",2444226;,3R01GM072778,01/28/2010,12/31/2010,"Address; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Architecture; Biological; Biological Models; Biology; Cells; Codon, Stop; Codon, Termination; Codon, Terminator; Complex; Coupled; Cues; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Elements; Engineering / Architecture; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Evolution; Gene Expression; Generalized Growth; Genetic; Goals; Growth; Hereditary; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Inherited; Investigation; Lewy Body Parkinson Disease; Light; Mediating; Model System; Modeling; Models, Biologic; Molecular; Morphology; Nature; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Organism; PSI; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Phenotype; Photoradiation; Physiologic; Physiological; Play; Population Biology; PrP; PrP Proteins; Primary Parkinsonism; Primary Senile Degenerative Dementia; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion Proteins; Prion-Induced Disorder; Prions; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Protein Structure Initiative; Proteins; Reading; Regulation; Research; Role; Route; Spongiform Encephalopathies, Transmissible; Stop Signal, Translation; Terminator Codon; Tissue Growth; Translations; Transmissible Dementias; Transmission; Variant; Variation; Virulence; Work; Yeasts; aberrant protein folding; abnormal protein folding; base; dementia of the Alzheimer type; disease/disorder; fitness; gene product; insight; insoluble aggregate; living system; loss of function; neurodegenerative illness; ontogeny; pathologic protein folding; pathway; primary degenerative dementia; prion hypothesis; protein aggregate; protein aggregation; protein mis-folding; protein misfolding; protein-only hypothesis; senile dementia of the Alzheimer type; social role; spongiform degeneration; spongiform encephalopathy; sup35; termination factor; trait; transmission process; yeast prion",A Prion Reveals Complex Traits and Phenotypic Diversity,,72778,GVE,Genetic Variation and Evolution Study Section,S1,5,149061,
8005175,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM073059-05S1,,NIGMS:262168;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,GENETICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"TANG, HUA ;",8066132;,3R01GM073059,01/20/2010,12/31/2010,"Accounting, Demographic; Address; Admixture; African; African American; Afro American; Afroamerican; American; Biological; Biomedical Research; Black Populations; Black or African American; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Causality; Chicanas; Chicanos; Complex; Confidence Intervals; Control Groups; Data; Demographic Accounting; Development; Diagnostic tests; Diathesis; Disease; Disease Outcome; Disease model; Disease susceptibility; Disorder; Employee Strikes; Environmental Factor; Environmental Risk Factor; Epidemiology; Equilibrium; Ethnic and Racial Minorities; Etiology; European; Family; Force of Gravity; Genetic; Genetic Markers; Genetics, Population; Genome; Genomics; Genotype; Goals; Gravities; Health; Hereditary; Hispanic Populations; Hispanics; Hispanics or Latinos; History; Immune; Individual; Inequality; Inherited; Intervention; Intervention Strategies; Investigators; Knowledge; Latino Population; Light; Link; Linkage Disequilibrium; Linkage Disequilibrium Mapping; Linkage Disequilibriums; Logistic Regressions; Maps; Measurement; Method LOINC Axis 6; Methodology; Methods; Mexican; Mexican Americans; Minority Groups; Modeling; Outcome; Persons; Philosophy; Photoradiation; Plague; Population; Population Control; Population Genetics; Predisposition gene; Preventive Intervention; Probability; Procedures; Recording of previous events; Regressions, Logistic; Research; Research Personnel; Researchers; Risk Factors; Science of Statistics; Scientist; Severities; Spanish Origin; Statistics; Stratification; Strikes; Strikes, Employee; Structure; Study Subject; Susceptibility Gene; Testing; Time; United States; Variant; Variation; Yersinia pestis disease; balance; balance function; base; black American; burden of disease; burden of illness; candidate marker; case control; design; designing; disease burden; disease causation; disease characteristic; disease etiology; disease risk; disease/disorder; disease/disorder etiology; disease/disorder proneness/risk; disorder etiology; disorder model; disorder risk; drift mapping; environment effect on gene; environmental risk; experience; experiment; experimental research; experimental study; gene environment interaction; genetic evolution; health disparities; health disparity; hispanic community; improved; interest; interventional strategy; liability to disease; novel; population based; predisposing gene; preventional intervention strategy; real world application; research study; simulation; social; statistics; theories; tool; years of life lost to disability; years of life lost to disease",Genetic Admixture and Confounding in Association Studies,,73059,GNM,Genome Study Section,S1,5,262168,
8003014,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM073832-04S1,,NIGMS:75913;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"PARRIS, DEBORAH S.;",1902417;,3R01GM073832,01/08/2010,12/31/2010,"Binding Sites; Biological Models; Cells; Combining Site; Complex; DNA; DNA Binding Domain; DNA Helicases; DNA Joinases; DNA Ligases; DNA Polymerases; DNA Primase; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA unwinding enzyme; DNA, Viral; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; DNA-Protein Interaction; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; EC 2.7.7.7; Enzymes; Eukaryota; Eukaryote; FLR; Failure (biologic function); Flap Endonucleases; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genome Stability; Genomic Instability; HHV-1; HSV; HSV-1; HSV1; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus hominis; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; In Vitro; Individual; Lead; Mammalian Cell; Mass Spectrum; Mass Spectrum Analysis; Model System; Modeling; Models, Biologic; Movement; Mutation; Okazaki fragments; Organism; Pb element; Photometry/Spectrum Analysis, Mass; Plasmids; Polydeoxyribonucleotide Ligases; Polydeoxyribonucleotide Synthetases; Polymerase; Primase; Process; Protein Motifs, DNA-Binding; Proteins; Proteomics; Reactive Site; Series; Simplexvirus; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stability, Genomic; System; System, LOINC Axis 4; Thinking; Thinking, function; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus Replication; Yeasts; body movement; eukaryotida; failure; gene product; genome mutation; heavy metal Pb; heavy metal lead; helicase; herpes simplex i; herpes virus 1, human; herpesvirus; human alphaherpesvirus 1; human herpesvirus 1 group; insight; living system; new approaches; novel approaches; novel strategies; novel strategy; protein protein interaction; seal; viral DNA; virus DNA; virus multiplication; virus protein",Coordination of HSV Lagging Strand Synthesis,,73832,VIRA,Virology - A Study Section,S1,4,75913,
8003036,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM074183-05S1,,NIGMS:130840;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WEST LAFAYETTE,UNITED STATES,BIOCHEMISTRY,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"BRIGGS, SCOTT D;",6589328;,3R01GM074183,01/20/2010,12/31/2010,"Acetylation; Address; Animals; Antibodies; Applications Grants; Biochemical; Biochemical Genetics; Biological; Blotting, Western; Cancers; Chromatin; Chromosomal dislocation; Chromosomal translocation; Co-Immunoprecipitations; Complex; Data; EC 2.1.1; Endomycetales; Environment; Enzymes; Exhibits; Expression Profiling; Expression Signature; Gene Action Regulation; Gene Deletion; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic, Biochemical; Genome; Goals; Grant Proposals; Grants, Applications; Histone H3; Histones; Homolog; Homologous Gene; Homologue; Human; Human, General; Individual; Insecta; Insects; Invertebrates, Insects; Investigators; L-Lysine; Laboratories; Lead; Letters; Lysine; MLL2; MLL2 gene; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Methods; Methylation; Methyltransferase; Modification; Molecular; Molecular Fingerprinting; Molecular Profiling; Mono-S; MonoS; Mutation; Organism; Pb element; Peptides; Phosphorylation; Photometry/Spectrum Analysis, Mass; Plants; Plants, General; Post-Translational Modifications; Post-Translational Protein Processing; Postdoc; Postdoctoral Fellow; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA Expression; Reagent; Regulation; Research; Research Associate; Research Personnel; Researchers; Role; S cerevisiae; SET Domain; Saccharomyces cerevisiae; Saccharomycetales; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Translocation, Genetic; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Up-Regulation; Western Blotting; Western Blottings; Western Immunoblotting; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; chromosome dislocation; chromosome translocation; deletion analysis; experiment; experimental research; experimental study; gene deletion mutation; gene product; genome mutation; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; human disease; in vivo; insight; living system; malignancy; methylase; molecuar profile; molecular signature; mutant; neoplasm/cancer; novel; post-doc; post-doctoral; programs; protein blotting; protein complex; protein protein interaction; research study; social role; transmethylase; ubiquination; ubiquitin conjugation",Role of Set1-mediated methylation in chromatin functioin,,74183,MGA,Molecular Genetics A Study Section,S1,5,130840,
8000162,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM074204-05S1,,NIGMS:69662;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BURLINGTON,UNITED STATES,PHARMACOLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"HOWE, ALAN K;",1894748;,3R01GM074204,01/14/2010,12/31/2010,"2 Dimensional Gel Electrophoresis; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; Actins; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adhesions; Assay; Autoregulation; Back; Bears; Behavior; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cancers; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Migration; Chemotaxis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytosolic Protein Tyrosine Phosphastase; Data; Development; Dorsum; EC 2.7; ECM; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Enzymes; Event; Extracellular Matrix; FRET; Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; GTPases; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Heart; Homeostasis; Image; Individual; Influentials; Integrin-mediated Cell Adhesion; Integrin-mediated Cell Adhesion Pathway; Intracellular Communication and Signaling; Investigators; Kinases; Life; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Methods and Techniques; Methods, Other; Microscopy; Molecular; Motility; Motility, Cellular; Organism; PDE; PKA; PTP-PEST; PTPG1; PTPN12; PTPN12 gene; PTPase; Pathologic Processes; Pathological Processes; Phosphodiesterases; Phosphorylation; Phosphotransferases; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Photometry/Spectrum Analysis, Mass; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; Protein Kinase; Protein Kinase A; Protein Kinase Interaction; Protein Phosphorylation; Protein Tyrosine Phosphatase; Proteins; Pseudopodia; Regulation; Research Personnel; Researchers; Role; Signal Transduction; Signal Transduction Systems; Signaling; Spatial Distribution; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Techniques; Testing; Transphosphorylases; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Ursidae; Ursidae Family; VASP; Work; adenosine 3'5' monophosphate; adenylcyclase; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cell motility; feeding; gene product; glycogen synthase a kinase; guanosinetriphosphatase; hydroxyalkyl protein kinase; imaging; living system; malignancy; migration; neoplasm/cancer; novel; phosphoric diester hydrolase; phosphorylase b kinase kinase; programs; protein kinase modulator; protein tyrosine phosphate phosphohydrolase; social role; vasodilator-stimulated phosphoprotein",Spatial regulation of Protein Kinase A in cell migration,,74204,CDF,Cell Development and Function Integrated Review Group,S1,5,69662,
8003038,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM074210-04S1,,NIGMS:110437;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"HIGGINS, JONATHAN M;",7113148;,3R01GM074210,01/08/2010,12/31/2010,"ATP[{..}]protamine O-phosphotransferase; Anaphase; Behavior; Binding; Binding (Molecular Function); Binding Proteins; Cancers; Cell division; Cells; Centromere; Centrosome; Chromatids; Chromatin; Chromosome Arm; Chromosome Cohesion; Chromosomes; Data; Defect; EC 2.7; Enzymes; Eukaryota; Eukaryote; Event; GeneHomolog; Generations; Genome; Haspin; Heterochromatin; Histone Code; Histone H3; Histone Kinase; Histones; Homolog; Homologous Gene; Homologue; Human; Human, General; Immunofluorescence; Immunofluorescence Immunologic; Immunofluorescence Microscopy; Immunologic, Immunofluorescence; In Vitro; Kinases; Knowledge; Lead; Life; Ligand Binding Protein; Location; M Phase; M phase (cell cycle); Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Metaphase; Microscopy, Immunofluorescence; Mitosis; Mitosis Stage; Mitotic; Mitotic Anaphase; Mitotic Metaphase; Modeling; Molecular Interaction; Mutate; N-terminal; NH2-terminal; Nature; Pattern; Pb element; Phenotype; Phosphorylation; Phosphotransferases; Physical condensation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pro-Metaphase; Process; Prometaphase; Prophase; Protamine Kinase; Protein Binding; Protein Phosphorylation; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Regulation; Role; Sequence-Specific Posttranscriptional Gene Silencing; Series; Sister Chromatid; Small Interfering RNA; Structure; Tail; Transphosphorylases; Work; base; cancer cell; cell imaging; cellular imaging; cohesin; cohesion; condensation; daughter cell; eukaryotida; gene product; heavy metal Pb; heavy metal lead; histone modification; insight; malignancy; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; overexpression; prevent; preventing; siRNA; social role",Function of the chromosomal kinase haspin in mitosis,,74210,MGC,Molecular Genetics C Study Section,S1,4,110437,
8000170,R01,GM,3,Y,01/28/2010,12/31/2010,,3R01GM074215-05S1,,NIGMS:79750;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,627922248,US,CA,920930660,LUDWIG INSTITUTE FOR CANCER RESEARCH,"DESAI, ARSHAD ;",8009630;,3R01GM074215,01/28/2010,12/31/2010,"Address; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Birth Defects; C elegans; C.elegans; CENP-A; Caenorhabditis elegans; Cell division; Cells; Centromere; Characteristics; Chemistry, Biological; Chromatin; Chromosomal Instability; Chromosome Condensation; Chromosome Instability; Chromosome Segregation; Chromosomes; Classification Scheme; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Dependence; Deposit; Deposition; Electron Microscopy; Embryo; Embryonic; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Essential Genes; Fertility/Fertilization; Fertilization; Gametes; Genes, Essential; Genome; Genomics; Germ Cells; Germ-Line Cells; Goals; Histone H3; Histones; Human; Human, General; In Vitro; Inheritance Patterns; Investigators; Kinetochores; Location; Man (Taxonomy); Man, Modern; Micro-tubule; Microtubules; Mitotic; Molecular Analysis; Molecular Genetic Abnormality; Molecular Interaction; Nature; Nucleosomes; Oncogenesis; Oocytes; Organelles; Outcome; Ovocytes; Phenotype; Physical condensation; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Racial Segregation; Reproductive Cells; Research Personnel; Researchers; Role; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Sex Cell; Site; Specific qualifier value; Specified; Staging; Structure; Testing; Time; Translating; Translatings; Variant; Variation; Work; base; centromere autoantigens 17K; centromere protein 17K; centromere protein A; chemotherapy; condensation; condensin; experiment; experimental research; experimental study; functional genomics; functional group; gene product; in vivo; initial cell; insight; language translation; novel; programs; protein complex; protein function; reconstitute; reconstitution; research study; screening; screenings; segregation; sexual cell; social role; tumorigenesis",Kinetochore Specification and Function,,74215,CDF,Cell Development and Function Integrated Review Group,S1,5,79750,
8003045,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM074245-05S1,,NIGMS:186349;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TUCSON,UNITED STATES,BIOLOGY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"NACHMAN, MICHAEL W.;",1925835;,3R01GM074245,01/20/2010,12/31/2010,"Address; Assay; Base Composition; Bioassay; Biologic Assays; Biological Assay; Candidate Disease Gene; Candidate Gene; Chromosome 1; Chromosome 15; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 15; Complex; DNA Recombination; DNA Sequence; DNA Sequence Analysis; DNA recombination (naturally occurring); Data; Demography; Disease; Disorder; Environment; Equilibrium; Evolution; Evolution, Molecular; Frequencies (time pattern); Frequency; G+C Compositions; G+C Content; GC Composition; GC Content; Gene variant; Genealogy; Geneologies; Genes; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Polymorphism; Genetic Recombination; Genetic Structures; Genetic Variation; Genetic defect; Genetics, Population; Genome; Genomics; Genotype; Goals; Guanine + Cytosine Composition; Guanine + Cytosine Content; Haplotypes; House mice; Human; Human, General; Inbred Strain; Inbred Strains Mice; Individual; Isochores; Laboratories; Link; Linkage Disequilibrium; Linkage Disequilibriums; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Inbred Strains; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Modeling; Molecular Evolution; Mouse Strains; Murine; Mus; Mus musculus; Mus musculus domesticus; Mutation; Natural Selections; Nucleotides; Ortholog; Orthologous Gene; Pattern; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Population Genetics; Population Studies / Demography; Position; Positioning Attribute; Process; Publishing; Recombination; Recombination, Genetic; Relative; Relative (related person); Reproduction; Research; SNP; SNPs; Scanning; Selections, Natural; Sequence Analyses, DNA; Sequence Analysis, DNA; Series; Shapes; Single Nucleotide Polymorphism; Site; Slide; Structure; Survey Instrument; Surveys; Testing; Variant; Variation; Variation (Genetics); Work; X Chromosome; allelic variant; autosome; balance; balance function; density; disease/disorder; domesticus, Mus; genome mutation; genome sequencing; genome, mouse; male; mouse genome; polymorphism; trait",Natural selection and DNA sequence variation in Mus,,74245,GEN,Genetics Study Section,S1,5,186349,
8002827,R01,GM,3,Y,01/08/2010,08/31/2010,,3R01GM074728-05S2,,NIGMS:85851;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOCHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"STRAIGHT, AARON F;",1872834;,3R01GM074728,01/08/2010,08/31/2010,"Affinity; Affinity Chromatography; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological; Biological Assay; CENP-A; Cell Survival; Cell Viability; Cells; Cellular Assay; Centromere; Chemistry, Biological; Chromatin; Chromatography, Affinity; Chromosome Segregation; Chromosomes; Complex; Cultured Cells; DISSEC; DNA; Deoxyribonucleic Acid; Dissection; Drosophila genome; Ensure; Enzymes; Eukaryota; Eukaryote; GeneHomolog; Genes; Genetic; Genomics; Goals; HDAC; HDAC Proteins; Histone Deacetylase; Histone H3; Histones; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Investigators; Kinetochores; M Phase; M phase (cell cycle); Macromolecular Protein Complexes; Man (Taxonomy); Man, Modern; Methods; Micro-tubule; Microtubules; Mitosis; Mitosis Stage; Mitotic Chromosome; Mitotic spindle; Molecular; Molecular Interaction; Monitor; Multiprotein Complexes; Nucleosomes; Phenotype; Platanna; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Research; Research Personnel; Researchers; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Site; Specific qualifier value; Specified; Sperm; Spermatozoa; Structure; System; System, LOINC Axis 4; Tail; Variant; Variation; Xenopus; Xenopus laevis; affinity purification; base; centromere autoantigens 17K; centromere protein 17K; centromere protein A; chromatin remodeling; daughter cell; egg; eukaryotida; experiment; experimental research; experimental study; gene product; genome, Drosophila; genome, fruit fly; programs; research study; screening; screenings; sperm cell; zoosperm",Mechanisms of Kinetochore Assembly,,74728,ZRG1,Special Emphasis Panel,S2,5,85851,
8000177,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM074751-02S1,,NIGMS:80862;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,BIOMEDICAL ENGINEERING,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"FLETCHER, DANIEL A;",7805570;,3R01GM074751,01/29/2010,12/31/2010,"Actin Filaments; Actin-Binding Protein; Actins; Affect; Atomic Force Microscopes; Behavior; Biochemical; Biological; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; Cell Communication and Signaling; Cell Junctions; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell division; Cell-Extracellular Matrix; Cells; Cellular Migration; Complement; Complement Proteins; Complex; Computer Architectures; Development; Disease; Disorder; ECM; Electric Field Microscopes; Endocytosis; Exocytosis; Extracellular Matrix; Filament; Fluorescence Microscopy; Generalized Growth; Growth; Health; Heterophil Granulocyte; History; Individual; Intercellular Junctions; Intracellular Communication and Signaling; Lateral Force Microscopes; Magnetic Force Microscopes; Marrow Neutrophil; Measurement; Measures; Mechanics; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Microfilaments; Microscopes, Scanning Probe; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Motility; Motility, Cellular; Movement; Myofilaments; Neoplasm Metastasis; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Phagocytosis; Physical environment; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Property; Property, LOINC Axis 2; Proteins; Recording of previous events; Regulation; Role; Scanning Probe Microscopes; Scanning Thermal Microscopes; Scanning Tunneling Microscopes; Secondary Neoplasm; Secondary Tumor; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Techniques; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Tissues; Tumor Cell Migration; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; base; biological signal transduction; body movement; cancer metastasis; cantilever; cell motility; cofilin; cross-link; crosslink; density; disease/disorder; drug discovery; experiment; experimental research; experimental study; gene product; in vitro Model; insight; mechanical behavior; network architecture; neutrophil; ontogeny; pathogen; profilin; public health relevance; research study; response; social role; thymus derived lymphocyte; tool",Mechanical Regulation of Actin Networks,,74751,ZRG1,Special Emphasis Panel,S1,2,80862,
8002867,R01,GM,3,Y,01/08/2010,11/30/2010,,3R01GM074917-05S1,,NIGMS:116991;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MINNEAPOLIS,UNITED STATES,BIOCHEMISTRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"BIELINSKY, ANJA-KATRIN ;",6985486;,3R01GM074917,01/08/2010,11/30/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; Affect; Applications Grants; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Cancer Treatment; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Cycle; Cell Division Cycle; Chaperone; Chromatin; Complex; DNA; DNA Polymerase Delta Auxiliary Protein; DNA Polymerase I; DNA Polymerase II; DNA Polymerase alpha; DNA Polymerase epsilon; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA polymerase alpha-primase; DNA-Dependent DNA Polymerase I; DNA-Dependent DNA Polymerase II; Deoxyribonucleic Acid; Eukaryote; Eukaryotic Cell; Event; Genetic Alteration; Genetic Change; Genetic defect; Grant Proposals; Grants, Applications; Half-Life; Half-Lifes; Investigators; Klenow Fragment; Macropain; Macroxyproteinase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Molecular Chaperones; Molecular Interaction; Multicatalytic Proteinase; Mutation; Nature; Nuclear; PCNA-Cyclin; Peptide Signal Sequences; Phase; Pol I; Pol II; Polymerase; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Pre-Replication Complex; Process; Proliferating Cell Nuclear Antigen; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteosome; Recruitment Activity; Replication Origin; Research Personnel; Researchers; Role; S cerevisiae; Saccharomyces cerevisiae; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Temperature; Ubiquitilation; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; Ubiquitination; Ubiquitinoylation; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; anticancer therapy; cancer therapy; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; multicatalytic endopeptidase complex; mutant; ori Region; pre-RC; protein signal sequence; recruit; research study; social role; ubiquination; ubiquitin conjugation",Understanding the biological function of Mcm10 in yeast,,74917,MGB,Molecular Genetics B Study Section,S1,5,116991,
8002873,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM075060-03S1,,NIGMS:153399;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLOOMINGTON,UNITED STATES,BIOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"MICHAELS, SCOTT ;",7931631;,3R01GM075060,01/08/2010,12/31/2010,"Affect; Alleles; Allelomorphs; Apical; Arabidopsis; Behavior; Biochemical; Biological; Biology; Blooms, Plant; Blossoms; Cell Communication and Signaling; Cell Signaling; Cells; Chromatin Structure; Complex; Coupled; Data; Development; Endogenous Factors; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Flowers; Gene Expression; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic analyses; Genetic defect; Goals; HDAC; HDAC Proteins; Histone Deacetylase; Homeo Domain; Human; Human, General; Individual; Interest Group; Intracellular Communication and Signaling; Knowledge; Laboratories; Left; Libraries; Life Cycle; Life Cycle Stages; Link; Man (Taxonomy); Man, Modern; Mediating; Meristem; Messenger RNA; Molecular; Molecular Analysis; Molecular Genetic; Molecular Genetics; Mother Cells; Mutation; Organ; Pathway interactions; Phenotype; Plants; Plants, General; Play; Polyadenylation Factor; Pre-mRNA Polyadenylation Factor; Primordium; Progenitor Cells; Proteins; RNA; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Binding Proteins; Regulation; Repression; Research; Ribonucleic Acid; Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Structure; Testing; Time; Two Hybrid; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; biological signal transduction; chromatin modification; design; designing; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; histone modification; homeodomain; insight; life course; loss of function mutation; mRNA; mutant; null mutation; overexpression; pathway; protein protein interaction; reproductive; reproductive success; research study; screening; screenings; social role; transcription factor; yeast two hybrid system",Molecular analysis of the autonomous pathway,,75060,DEV1,Development - 1 Study Section,S1,3,153399,
8002877,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM075152-02S1,,NIGMS:152640;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SEATTLE,UNITED STATES,,07,135646524,US,WA,981038904,INSTITUTE FOR SYSTEMS BIOLOGY,"AITCHISON, JOHN D.;",6879104;,3R01GM075152,01/08/2010,12/31/2010,"Aging; Biogenesis; Cancer Causing Agents; Cancers; Carcinogens; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell model; Cells; Cellular model; Complex; Computer Analysis; Data; Data Collection; Developmental Process; Diabetes Mellitus; Drugs; Fats; Fatty Acids; Fatty acid glycerol esters; Future; GWAS; Gene Expression; Gene Transcription; Generations; Genes, Regulator; Genetic Transcription; Goals; Health; Heart Diseases; Hereditary; Housing; Human; Human, General; Inherited; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinetic; Kinetics; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Math Models; Medication; Metabolic Pathway; Modeling; Obesity; Oleic Acids; Oncogens; Organelles; Origin of Life; Peroxisome Proliferation; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Programs (PT); Programs [Publication Type]; RNA Expression; Regulator Genes; Research; S cerevisiae; Saccharomyces cerevisiae; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Stimulus; System; System, LOINC Axis 4; Testing; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Yeast, Baker's; Yeast, Brewer's; Yeasts; adiposity; base; biological signal transduction; computational analysis; computer based prediction; corpulence; corpulency; corpulentia; design; designing; diabetes; drug/agent; experiment; experimental research; experimental study; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heart disorder; improved; interventional strategy; malignancy; mathematical model; mathematical modeling; neoplasm/cancer; network models; neuropathology; new approaches; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; peroxisome; predictive modeling; programs; public health relevance; regulatory gene; research study; response; senescent; simulation; trans acting element; transcription factor; whole genome association studies; whole genome association study",Oleate-responsive gene regulatory networks governing peroxisome proliferation,,75152,ZRG1,Special Emphasis Panel,S1,2,152640,
8000191,R01,GM,3,Y,01/14/2010,12/31/2010,,3R01GM075205-03S2,,NIGMS:123328;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PITTSBURGH,UNITED STATES,BIOLOGY,14,052184116,US,PA,15213,CARNEGIE-MELLON UNIVERSITY,"MURPHY, ROBERT F.;",1905096;,3R01GM075205,01/14/2010,12/31/2010,"Amino Acid Sequence; Behavior; Build-it; Cell Line; Cell Lines, Strains; CellLine; Cells; Chimera Protein; Chimeric Proteins; Coin; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, Protein; Development; Disease; Disorder; Fluorescence Microscopy; Fusion Protein; Gene Proteins; Genes; Goals; Image; Image Analyses; Image Analysis; Investigators; Journal Article; Journal Article (PT); Journal Article [Publication Type]; Knowledge; Learning, Machine; Life; Link; Literature; Location; Machine Learning; Mammalian Cell; Methods; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular Analysis; Molecular Biology, Protein Sequencing; NIH 3T3 Cells; NIH/3T3; Nucleotides; Pattern; Peptide Sequence Determination; Programs (PT); Programs [Publication Type]; Protein Databases; Protein Gene Products; Protein Sequencing; Protein Structure, Primary; Proteins; Proteomics; ROC Analysis; Research Personnel; Researchers; Resolution; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Sight; Source; System; System, LOINC Axis 4; Systems Biology; Time; UV laboratory microscope; Ultraviolet Microscopes; Vision; Work; base; cell behavior; cell imaging; cellular imaging; clinical data repository; clinical data warehouse; computerized; cultured cell line; data repository; disease/disorder; fluorescence microscope; fluorescence/UV microscope; fluorescent microscope; gene product; image evaluation; imaging; journal article; kernel methods; laboratory fluorescence light microscope; programs; protein distribution; protein sequence; relational database; software systems; statistical learning; support vector machine",Building and Validating Location Proteomics Databases,,75205,BDMA,Biodata Management and Analysis Study Section,S2,3,123328,
8002880,R01,GM,3,Y,01/15/2010,12/31/2010,,3R01GM075363-04S1,,NIGMS:106981;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OKLAHOMA CITY,UNITED STATES,,05,077333797,US,OK,731045005,OKLAHOMA MEDICAL RESEARCH FOUNDATION,"DAWSON, DEAN S;",1890239;,3R01GM075363,01/15/2010,12/31/2010,"Age; Anaphase; Aneuploid; Aneuploidy; Animal Model; Animal Models and Related Studies; Behavior; Birth Defects; Cannot achieve a pregnancy; Cells; Centromere; Chromosome 2; Chromosome Pairing; Chromosome Segregation; Chromosomes; Chromosomes, Human, Pair 2; Conceptus; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA Recombination; DNA Sequence; DNA recombination (naturally occurring); Difficulty conceiving; Exhibits; FLR; Failure (biologic function); GeneHomolog; Genes; Genetic Recombination; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; I Kappa B A; I Kappa B-Alpha; I kappa B-alpha protein; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IkappaBalpha; Incidence; Infertility; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Investigators; Kinetochores; Lead; Length; Link; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Man (Taxonomy); Man, Modern; Maternal Age; Mediating; Meiosis; Meiotic Recombination; Micro-tubule; Microtubules; Miscarriage; Mitotic Anaphase; Modeling; Modification; Molecular Genetic Abnormality; Monosomy X; Morgagni-Turner syndrome; Morgagni-Turner-Albright syndrome; NF-Kappa B Inhibitor Alpha; NF-kappaB inhibitor alpha; NFKBI; NFKBIA; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Participant; Pb element; Play; Probability; Process; Programs (PT); Programs [Publication Type]; Prophase; Proteins; Racial Segregation; Randomized; Recombination; Recombination, Genetic; Research Personnel; Researchers; Role; Shereshevskii-Turner syndrome; Side; Sister Chromatid; Spontaneous abortion; Synapsis; Synapsis, Chromosomal; Testing; Time; Turner syndrome (TS); Turner's Syndrome; Turner-Albright syndrome; Ullrich-Turner syndrome; Ullrich-Turner syndrome (UTS); Woman; XO syndrome; Yeasts; age at pregnancy; base; chromosome XO syndrome; cohesion; experience; experiment; experimental research; experimental study; failure; gene product; genital dwarfism; heavy metal Pb; heavy metal lead; infertile; meiotic; model organism; monosomy X syndrome; ovarian dwarfism; ovarian short stature syndrome; p40 protein (IkappaB-alpha); primary ovarian insufficiency; programs; pseudonuchal infantilism; randomisation; randomization; randomly assigned; research study; segregation; social role; unable to bear children",Segregation of error-prone chromosomes in meiosis,,75363,MGC,Molecular Genetics C Study Section,S1,4,106981,
8005232,R01,GM,3,Y,01/28/2010,12/31/2010,PA-01-071,3R01GM075986-05S1,,NIGMS:103704;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"GOLDSTEIN, LEE E;",1934361;,3R01GM075986,01/28/2010,12/31/2010,"Age; Air; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyloid; Amyloid Substance; Aqueous Humor; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Biological Models; Biometals; Blood Plasma; Blotting, Western; Body Tissues; Brain; Cataract; Cell/Tissue, Immunohistochemistry; Cellular biology; Cerebrum; Chaperone; Chemistry, Biological; Clinical Evaluation; Clinical Testing; Crystalline Lens; Crystallins; Cytoplasm; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deposit; Deposition; Detection; Development; Diagnostic; Diagnostic Imaging; Disease; Disease model; Disorder; Dysfunction; ELISA; Electron Microscopy; Encephalon; Encephalons; Enzyme-Linked Immunosorbent Assay; Event; Eye; Eyeball; Fluorescence; Fluorescence Microscopy; Functional disorder; Gases; Goals; Grant; Histopathology; Human; Human, General; IHC; Immune Precipitation; Immunohistochemistry; Immunohistochemistry Staining Method; Immunoprecipitation; In Vitro; Incubated; Individual; Instrumentation, Other; Intraocular Fluid; Investigators; Iris; Iris (Eye); Isoforms; Kinetic; Kinetics; Knock-out; Knockout; Label; Len, Crystalline; Len, Eye; Length of Life; Lens; Lens Fiber; Lens Proteins; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Ligand Binding; Longevity; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediating; Metalloproteins; Metals; Mice; Mice, Transgenic; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Model System; Modeling; Models, Biologic; Molecular; Molecular Chaperones; Molecular Interaction; Monitor; Murine; Mus; Nervous System, Brain; Non-Invasive Cancer Detection; Non-Invasive Detection; Ocular Lens; Ophthalmoscopy; Optical Instrument; Optics; Optics/Optical Instrument; Organ; Oxidation-Reduction; Pathogenesis; Pathology; Patients; Penetrance; Peptides; Phenotype; Photometry/Spectrum Analysis, Mass; Physiopathology; Plasma; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Recombinants; Redox; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Roentgen Rays; Serum, Plasma; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structural Protein; Technology; Testing; Tg2576; Tissues; Trace Elements; Trace Mineral; Transgenes; Transgenic Mice; Western Blotting; Western Blottings; Western Immunoblotting; X-Radiation; X-Rays; Xrays; age dependent; age related; aged; amyloid pathology; biomarker; cataractogenesis; cataractous lenses; cell biology; clinical test; cohort; dementia of the Alzheimer type; disease control; disease/disorder; disorder control; disorder model; experiment; experimental research; experimental study; fiber cell; gene product; in vitro Model; in vivo; indexing; insight; instrument; instrumentation; lens; lens protein; life span; lifespan; light scattering; metal chelator; mutant; normal aging; novel; overexpression; oxidation reduction reaction; pathophysiology; primary degenerative dementia; programs; protein aggregation; protein blotting; research clinical testing; research study; senile dementia of the Alzheimer type",AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING,,75986,ZRG1,Special Emphasis Panel,S1,5,103704,
8002881,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM076021-03S1,,NIGMS:32430;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"FISHER, ROBERT P;",1931525;,3R01GM076021,01/08/2010,12/31/2010,"Animal Model; Animal Models and Related Studies; BTF2 transcription factor; Basal Transcription Factor; Binding; Binding (Molecular Function); Biochemical Genetics; Biological Models; Bypass; CDC2 Protein Kinase; CDK; CDK1; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Controller cdc2; Cell Division Control Protein 2 Homolog; Cell Division Cycle; Cell Division Cycle 2; Cell Division Cycle 2 Protein; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell division; Cells; Cellular Proliferation; Chemicals; Complex; Coupling; Cyclin-Dependent Kinase 1; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA-Dependent RNA Polymerase II; Defect; Dependency; Dependency (Psychology); EC 2.1.1; EC 2.7; Elongation Factor; Endomycetales; Engineering; Engineerings; Ensure; Enzymes; Eukaryota; Eukaryote; Event; Factor, Elongation; Fission Yeast; Gene Expression; Gene Transcription; GeneHomolog; General Transcription Factors; Generalized Growth; Genes; Genetic; Genetic Transcription; Genetic, Biochemical; Genome; Genomics; Goals; Growth; Hand; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Kinases; Laboratories; Link; Logic; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Measures; Mediating; Messenger RNA; Methyltransferase; Model System; Modeling; Models, Biologic; Molecular Interaction; Normal Tissue; Normal tissue morphology; Organism; Ortholog; Orthologous Gene; P-TEFb; Pathway interactions; Pattern; Phosphorylation; Phosphotransferases; Play; Polymerase; Positive Transcription Elongation Factor B; Positive Transcriptional Elongation Factor B; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Quality Control; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA chemical synthesis; RNA synthesis; RNA, Messenger; Refractory; Research; Resistance; Role; S cerevisiae; S pombe; Saccharomyces cerevisiae; Saccharomycetales; Schizosaccharomyces pombe; Signal Transduction; Signal Transduction Systems; Signaling; TFIIH; Testing; Tissue Growth; Toxic effect; Toxicities; Transcript; Transcription; Transcription Elongation; Transcription Factors, General; Transcription, Genetic; Translating; Translatings; Transphosphorylases; Tumor Cell; Unscheduled DNA Synthesis; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeast, Fission; analog; basic transcription factor 2; biological signal transduction; cancer progression; capping of mRNA; cdc2 gene product; cdc2+ Protein; cdk Proteins; cdk1 Kinase; chemical genetics; cyclin H; design; designing; emotional dependency; eukaryotida; gene product; homologous recombination; in vivo; inhibitor; inhibitor/antagonist; language translation; living system; mRNA; mRNA capping; malignancy; methylase; model organism; mutant; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; ontogeny; p34 (cdc2); p34 Protein Kinase; p34CDC2; pathway; programs; public health relevance; resistant; response; small molecule; social role; tat-Associated Kinase; tool; transcription factor IIH; transcription factor TFIIH; transmethylase; tumor progression; upstream kinase",The CDK Activation Network of Fission Yeast,,76021,NDT,Nuclear Dynamics and Transport,S1,3,32430,
8002737,R01,GM,3,Y,01/20/2010,12/31/2010,,3R01GM076237-04S1,,NIGMS:101371;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"LUO, XU ;",8243808;,3R01GM076237,01/20/2010,12/31/2010,"Amino Acids; Apoptosis; Apoptosis Pathway; Apoptosis Regulator; Apoptotic; Assay; Autoregulation; BAX; BAX Isoform Alpha; BCL2-Associated X Protein; BH3 Domain; Bax protein; Bioassay; Biochemical; Biochemical Pathway; Biochemistry; Biologic Assays; Biological Assay; Blood (Leukemia); Body Tissues; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chemistry, Biological; Cytoplasm; DNA Molecular Biology; Development; Dimerization; Disease; Disorder; Family member; Genetic; Goals; Homeostasis; Homo; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; Knowledge; Lead; Leukemias, General; Location; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Networks; Methods and Techniques; Methods, Other; Mitochondria; Molecular; Molecular Biology; Monitor; Organism; Outer Mitochondrial Membrane; Pathway interactions; Pb element; Physiological Homeostasis; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Dimerization; Protein Family; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Regulation; Research; Research Personnel; Research Proposals; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; System; System, LOINC Axis 4; Techniques; Technology; Therapeutic; Therapeutic Agents; Tissues; Transfection; UV induced; Uncertainty; aminoacid; anticancer therapy; base; biological signal transduction; cancer therapy; design; designing; disease/disorder; doubt; feeding; gene product; heavy metal Pb; heavy metal lead; in vitro Assay; in vivo; insight; leukemia; living system; malignancy; mitochondrial; mouse model; mutant; neoplasm/cancer; pathway; prevent; preventing; programs; siRNA; social role; stem",Mechanisms of Bax Activation,,76237,CSD,Cellular Signaling and Dynamics Study Section,S1,4,101371,
7993617,R01,GM,3,Y,01/08/2010,11/30/2010,,3R01GM078176-03S1,,NIGMS:99870;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"KIGER, AMY A;",6844631;,3R01GM078176,01/08/2010,11/30/2010,"Animals; Assay; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Cancers; Cell Communication and Signaling; Cell Cycle Kinetics; Cell Function; Cell Kinetics; Cell Process; Cell Shape; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Morphology; Cellular Physiology; Cellular Process; Centronuclear myopathy; Charcot Marie Disorder; Charcot Marie Muscular Atrophy; Charcot Marie Tooth Disorder; Charcot Marie Tooth muscular atrophy; Charcot-Marie Disease; Charcot-Marie-Tooth; Charcot-Marie-Tooth Disease; Charcot-Marie-Tooth neuropathy; Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-, (2beta,3beta,5beta,22R)-; Cytoskeletal System; Cytoskeleton; DISSEC; Data; Defect; Degenerative Disorder; Development; Disease; Disorder; Dissection; Drosophila; Drosophila genome; Drosophila genus; Ecdysone; Endosomes; Family; Family member; Fruit Fly, Drosophila; GeneHomolog; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; High Throughput Assay; Homeostasis; Homolog; Homologous Gene; Homologue; Human; Human, General; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigators; Lipids; Lysosomes; MTM1 protein; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Membrane; Molecular; Molting Hormone; Morphogenesis; Morphology; Mutation; Myopathy, Myotubular; Neuropathy; Pathology; Pathway interactions; Peroneal Muscular Atrophy; Phenotype; Phosphatases; Phosphates; Phosphatidyl Inositol; Phosphatidylinositols; Phosphohydrolases; Phosphoinositide Pathway; Phosphoinositides; Phosphoinositides and their downstream targets; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiological Homeostasis; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Protein Family; Proteins; PtdINS3P; PtdIns; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptosomes; Regulation; Research; Research Personnel; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sterility; Subcellular Process; System; System, LOINC Axis 4; Testing; Yeasts; base; biological signal transduction; cell morphology; centronuclear myopathy (CNM); degenerative condition; degenerative disease; design; designing; developmental genetics; disease/disorder; fruit fly; functional genomics; gene product; genetic analysis; genetic manipulation; genome mutation; genome, Drosophila; genome, fruit fly; genome-wide; high throughput screening; in vivo; inorganic phosphate; insight; intracellular skeleton; late endosome; loss of function; malignancy; membrane structure; mutant; myotubularin; neoplasm/cancer; neuropathic; novel; pathway; phosphatidylinositol 3-monophosphate; phosphatidylinositol 3-phosphate; phosphoinositide 3-phosphate; programs; protein expression; response; social role; sterile",Function of Myotubularin Phosphoinositide Phosphatase in Morphogenesis,,78176,DEV2,Development - 2 Study Section,S1,3,99870,
8000359,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM078222-03S1,,NIGMS:118849;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAINT LOUIS,UNITED STATES,BIOCHEMISTRY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"STORMO, GARY D;",1880876;,3R01GM078222,01/08/2010,12/31/2010,"Algorithms; Animal Model; Animal Models and Related Studies; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cataloging; Catalogs; Cells; ChIP (chromatin immunoprecipitation); Code; Coding System; Combining Site; Computing Methodologies; Conserved Sequence; Custom; D-Glucose; DNA; DNA-Binding Proteins; Data; Deoxyribonucleic Acid; Development; Dextrose; Engineered Gene; EngineeredGene; Engineering; Engineerings; Frequencies (time pattern); Frequency; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; General Transcription Factor Gene; Genes; Genes, Regulator; Genomics; Glucose; Goals; Hybrids; In Vitro; Investigators; Knowledge; Learning; Libraries; Logic; Maps; Math Models; Measurement; Metabolic Pathway; Methods; Modeling; Molecular Interaction; Mother Cells; Nature; Oligo; Oligonucleotides; Pattern; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Biochips; Protein Chips; Protein Microarray; Protein Microchips; Proto-Oncogene, Transcription Factor; Reactive Site; Regulator Genes; Research Personnel; Researchers; S cerevisiae; Saccharomyces cerevisiae; Site; Specificity; Stem cells; Study models; Targetings, Gene; Testing; Transcription factor genes; Transcriptional Regulatory Elements; Weight; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; cell engineering; cellular engineering; chromatin immunoprecipitation; combinatorial; computational methodology; computational methods; computer based prediction; computer methods; design; designing; experiment; experimental research; experimental study; gel mobility shift assay; genetic promoter element; genome-wide; in vivo; mathematical model; mathematical modeling; model organism; new technology; novel; predictive modeling; programs; regulatory gene; research study; response; tool; trans acting element; transcription factor",Deciphering the regulatory code of a cell,,78222,GCAT,"Genomics, Computational Biology and Technology Study Section",S1,3,118849,
8001166,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM078279-04S1,,NIGMS:234337;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"BIRNBAUM, KENNETH DAVID;",6445538;,3R01GM078279,01/08/2010,12/31/2010,"21+ years old; Address; Adult; Animals; Arabidopsis thaliana; Body Tissues; Cataloging; Catalogs; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Cress, Mouse-ear; Development; ES cell; Event; Genes; Genomics; Human, Adult; Individual; Life; Mammalia; Mammals; Mammals, General; Measures; Methods; Microscopy; Modeling; Molecular; Monitor; Mother Cells; Mouse-ear Cress; Natural regeneration; Organ; Plant Model; Plants; Plants, General; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Progenitor Cells; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regeneration; Resolution; Root Tip; Sequence-Specific Posttranscriptional Gene Silencing; Side; Stem cells; Structure; Subcellular Process; System; System, LOINC Axis 4; Tissues; Use of New Techniques; Work; adult human (21+); adult stem cell; analytical tool; cell damage; cell injury; cell type; developmental plasticity; embryonic stem cell; flexibility; in vivo regeneration; insight; mutant; regenerate; regenerate new tissue; regenerating damaged tissue; repair; repaired; stem cell fate; stem cell of embryonic origin; tissue regeneration",A Global View of Regenerating Plant Cells,,78279,DEV1,Development - 1 Study Section,S1,4,234337,
7811029,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM078296-04S1,,NIGMS:176047;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLOTTESVILLE,UNITED STATES,PHYSIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"BUSHWELLER, JOHN HACKETT;",1889450;,3R01GM078296,01/29/2010,12/31/2010,"Antibiotic Agents; Antibiotic Drugs; Antibiotics; Assay; Attenuated; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial Infections; Bacterial resistant; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Catalysis; Cause of Death; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chemicals; Data; Development; Drug resistance; E coli; Enzymes; Escherichia coli; Fluorescence; Funding; GeneHomolog; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; HOSP; Homolog; Homologous Gene; Homologue; Hospitals; Host Defense; Human; Human, General; Infection; Integral Membrane Protein; Intensive Care Units; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Killings; Lead; Man (Taxonomy); Man, Modern; Mediating; Membrane; Miscellaneous Antibiotic; Modeling; Molecular Interaction; Motility; Motility, Cellular; Mutation; NIH; NMR Spectroscopy; National Institutes of Health; National Institutes of Health (U.S.); Oxidants; Oxidizing Agents; Pb element; Periplasmic Space; Pressure; Pressure- physical agent; Proteins; Quinone Compound; Quinones; Recovery; Series; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Spectroscopy, NMR; Structure; System; System, LOINC Axis 4; Testing; Toxin; Transmembrane Protein; United States National Institutes of Health; Virulence; analog; bacterial disease; bacterial resistance; base; biological signal transduction; cell motility; disulfide bond; drug resistant; electron acceptor; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; membrane structure; mutant; new approaches; novel approaches; novel strategies; novel strategy; nuclear magnetic resonance spectroscopy; overgrowth bacterial; oxidation; periplasm; periplasmic; pressure; protein function; public health relevance; resistance to Bacteria; resistance to Bacterial; resistance to Drug; resistant to Bacteria; resistant to Bacterial; resistant to Drug; small molecule",Solution NMR Structure and Function of the Integral Membrane Protein DsbB," DsbB is an important protein for the functioning of many proteins that mediate the ability of bacteria to enter human cells, inject material into those cells, and to release toxins. All these functions contribute to the effects of bacterial infections on humans. Therefore, if we can inhibit the ability of bacteria to do this, we will have a new approach to treat bacterial infections. To that end, we are proposing to develop inhibitors of DsbB, a new potential approach to treating bacterial infections.",78296,ZRG1,Special Emphasis Panel,S1,4,176047,
8003080,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM078481-03S1,,NIGMS:55207;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,GENETICS,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"FERGUSON, EDWIN L;",1897754;,3R01GM078481,01/08/2010,12/31/2010,"Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Anaplastic; Anchoring Junction; Anterior; Antibodies; Attention; Autoregulation; Biosensor; Blood; Body Tissues; Bone Morphogenetic Proteins; Cell Communication and Signaling; Cell Function; Cell Growth and Maintenance; Cell Maintenance; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Complex; Crossmatching, Tissue; Data; Daughter; Disease; Disorder; Drosophila; Drosophila genus; Drosophila melanogaster; Ensure; Environment; Family member; Feedback; Female; Fruit Fly, Drosophila; Gene Transcription; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Germ Lines; Hair; Healed; Histocompatibility Testing; Homeostasis; Homolog; Homologous Gene; Homologue; Injury; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; Knowledge; Left; Life; Ligands; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Maintenance; Maintenances; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Morphology; Mother Cells; Mutation; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nuclear; Oocytes; Ovocytes; PRKM8; Pathway interactions; Pattern; Phenotype; Physiological Homeostasis; Progenitor Cells; Protein Family; Proteins; RNA Expression; Receptor Activation; Reticuloendothelial System, Blood; Role; SAPK1; SIS; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sister; Skin; Small G-Proteins; Small GTPases; Stem cells; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic; Tissue Crossmatchings; Tissue Typing; Tissues; Transcription; Transcription, Genetic; Transducers; Undifferentiated; adult stem cell; base; biological signal transduction; bone morphogenetic protein receptors; design; designing; disease/disorder; experiment; experimental research; experimental study; extracellular; fruit fly; gene product; genome mutation; healing; histocompatibility typing; in vivo; insight; member; neuronal; pathway; receptor internalization; receptor, BMP; research study; response; self-renewal; sensor (biological); social role; stem cell differentiation; stem cell division; stem cell fate; stem cell niche; uptake",Maintenance of Stem Cell Fates in Drosophila,,78481,DEV1,Development - 1 Study Section,S1,3,55207,
8003335,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM078536-03S1,,NIGMS:135175;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WEST LAFAYETTE,UNITED STATES,MISCELLANEOUS,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"SALT, DAVID E;",8578403;,3R01GM078536,01/08/2010,12/31/2010,"Agriculture; Alleles; Allelomorphs; Analysis, Data; Arabidopsis; Arabidopsis thaliana; Automobile Driving; Autoregulation; Biochemical; Biological; Blood Plasma; Body Tissues; Chromosome Mapping; Classification; Collection; Computers; Coupled; Cress, Mouse-ear; Data; Data Analyses; Data Set; Dataset; Disease; Disorder; Drivings, Automobile; Elements; Environment; Equilibrium; Fixation; Food; Future; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Models; Genetic Polymorphism; Genetic Variation; Genetics, Gene Mapping; Genetics, Population; Genome; Genotype; Geographic Distribution; Haplotypes; Health; Homeostasis; Human; Human, General; Hydroponic; Hydroponics; Informatics; Investigation; Investigators; Ions; Laboratories; Light; Link; Linkage Disequilibrium Mapping; Linkage Mapping; Macronutrients; Macronutrients Nutrition; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Management Information Systems; Maps; Mass Spectrum; Mass Spectrum Analysis; Measures; Micronutrients; Minerals; Minerals Nutrition; Modeling; Models, Genetic; Mouse-ear Cress; Natural Selections; Nutrition; Nutrition, Macronutrients; Nutrition, Minerals; Nutritional Science; Organism; Pattern; Phenotype; Photometry/Spectrum Analysis, Mass; Photoradiation; Physiological Homeostasis; Plant Embryos; Plant Roots; Plants; Plants, General; Plasma; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Genetics; Process; Programs (PT); Programs [Publication Type]; QTL; Quantitative Trait Loci; Recombinants; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; SEQ-AN; Science of Statistics; Science of nutrition; Seeds; Selections, Natural; Sequence Analyses; Sequence Analysis; Serum, Plasma; Soil; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Statistics; Survey Instrument; Surveys; System; System, LOINC Axis 4; Systematics; Tissues; Transcript; Variant; Variation; Variation (Genetics); Zygotes, Plant; agricultural; allelic variant; analytical tool; balance; balance function; base; disease/disorder; drift mapping; driving; gene function; genetic mapping; improved; living system; nutrition; polymorphism; positional cloning; programs; response; reverse genetics; root; sample fixation; seed; social role; statistics; tool; trait",The Genetic Basis of Natural Ionomic Variation,,78536,GVE,Genetic Variation and Evolution Study Section,S1,3,135175,
8004334,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM078555-03S1,,NIGMS:193327;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,ANATOMY/CELL BIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"HUANG, SUI ;",1870217;,3R01GM078555,01/08/2010,12/31/2010,"Address; Antibodies; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; CRNA; Cancers; Cell Extracts; Cell Nucleolus; Cells; Complementary RNA; Complex; DNA Polymerase II; DNA Polymerase III; DNA Polymerase delta; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; DNA-Dependent DNA Polymerase III; Functional RNA; Gene Products, RNA; Goals; HeLa; Hela Cells; In Situ; In Vitro; Intermediary Metabolism; Lead; Life; Life Cycle; Life Cycle Stages; METBL; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Membrane; Metabolic Processes; Metabolism; Modeling; Molecular; Molecular Interaction; Non-Coding; Non-Coding RNA; Normal Cell; Nuclear; Nucleases, RNA; Nucleoplasm; PTB Protein; PTB Splicing Factor; Pb element; Plasmosome; Pol II; Pol III; Polypyrimidine Tract-Binding Protein; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Pre-mRNA; Process; Protein Subunits; Proteins; Proteomics; RNA; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA-Binding Proteins; RNase; Regulation; Ribonuclease Family Protein; Ribonucleases; Ribonucleic Acid; Role; Solutions; Structure; Testing; Work; cDNA Library; gene product; heavy metal Pb; heavy metal lead; in vivo; life course; mRNA Precursor; malignancy; membrane structure; neoplasm/cancer; novel; nucleolus; p57 Cytoplasmic RNA-Binding Protein; pPTB; pPTB (polypyrimidine tract binding protein); premRNA; protein complex; protein profiling; social role",The Structure and Function of Perinucleolar Compartment,,78555,NDT,Nuclear Dynamics and Transport,S1,3,193327,
8004512,R01,GM,3,Y,01/08/2010,12/31/2010,PAR-05-080,3R01GM079114-03S2,,NIGMS:142739;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,RALEIGH,UNITED STATES,CHEMISTRY,04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"DEITERS, ALEXANDER ;",8444731;,3R01GM079114,01/08/2010,12/31/2010,"Actinic Rays; Binding; Binding (Molecular Function); Biological; Brachydanio rerio; Catalytic RNA; Cells; Chemicals; Communities; Danio rerio; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Engineering; Engineerings; Functional RNA; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Genes; Genes, Switch; Genetic; Goals; In Vitro; Individual; Investigators; Isomerism; Light; Mediating; Method LOINC Axis 6; Methodology; Methods; Modeling; Molecular Interaction; Non-Coding; Non-Coding RNA; Oligo; Oligonucleotides; Organic Synthesis; Organism; Photoradiation; Plasmids; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Quelling; RNA; RNA Binding; RNA Interference; RNA Sequences; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; Receptor Cell; Receptor Protein; Recovery; Regulation; Research Personnel; Researchers; Resolution; Ribonucleic Acid; Ribozymes; Sequence-Specific Posttranscriptional Gene Silencing; Sequences, RNA; Sun/Ultra-Violet Rays; Switch Genes; System; System, LOINC Axis 4; Technology; Toxic effect; Toxicities; Transgenes; Transgenic Organisms; UV irradiated; UV irradiation; UV irridated; UV radiation; Ultraviolet Rays; Zebra Danio; Zebra Fish; Zebrafish; aptamer; base; biological systems; gene function; human disease; infancy; infantile; interest; irradiation; isomer; knock-down; living system; novel; phosphodiester; programs; receptor; small molecule; spatiotemporal; tool; transgene expression; transgenic; ultra violet irradiation; ultraviolet irradiation; ultraviolet light; ultraviolet radiation; web page",Switchable Systems for Spatio-Temporal Control of Gene Expression in Zebrafish,,79114,ZRG1,Special Emphasis Panel,S2,3,142739,
8005326,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM079477-03S1,,NIGMS:121405;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"BELASCO, JOEL G.;",1884346;,3R01GM079477,01/08/2010,12/31/2010,"5'-Adenylic acid, homopolymer; Abscission; Address; Animals; Awareness; Awarenesses; Binding; Binding (Molecular Function); Biological; Biological Models; Birth Defects; Cancers; Causality; Cells; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Decay, mRNA; Defect; Degradation, mRNA; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Elements; Etiology; Excision; Extirpation; Functional disorder; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Goals; Human; Human, General; Investigation; Isoforms; Knowledge; Language; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Medical; Messenger RNA; Methods; Micro RNA; MicroRNAs; Model System; Models, Biologic; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Physiopathology; Play; Poly A; Poly(A) Tail; Poly(rA); Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Protein Isoforms; Proteins; Putative RNA-Binding Region; Quelling; RBD; RNA Binding Domain; RNA Interference; RNA Recognition Motif; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; RNP Domain; RNP Motif; RNP-1 Signature; RRM; Regulation; Removal; Repression; Research; Role; Scanning; Sequence-Specific Posttranscriptional Gene Silencing; Site; Small RNA; Stability, mRNA; Surgical Removal; Time; Translation Initiation; Translational Inhibition; Translational Repression; Translations; Viral Diseases; Virus Diseases; analytical tool; base; cofactor; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gene product; improved; improved functioning; insight; interest; mRNA; mRNA Decay; mRNA Stability; mRNA Transcript Degradation; malignancy; miRNA; neoplasm/cancer; pathophysiology; polyadenylate; resection; social role; viral infection; virus infection",Mechanisms of Gene Regulation by MicroRNAs,,79477,MGC,Molecular Genetics C Study Section,S1,3,121405,
8005369,R01,GM,3,Y,01/25/2010,12/31/2010,PA-07-070,3R01GM079483-02S1,,NIGMS:212968;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ALBUQUERQUE,UNITED STATES,BIOLOGY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"GERRISH, PHILIP JOHN;",8927415;,3R01GM079483,01/25/2010,12/31/2010,"Affect; Alleles; Allelomorphs; Biological; Biology; Cancers; Clonal Evolution; Clonality; Communicable Diseases; Complement; Complement Proteins; Computer Simulation; Computerized Models; DISSEC; DNA Recombination; DNA recombination (naturally occurring); Data; Defect; Disadvantaged; Dissection; E coli; Engineering; Engineerings; Escherichia coli; Eukaryota; Eukaryote; Evolution; Extinction; Extinction (Psychology); Face; Frequencies (time pattern); Frequency; Friends; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic analyses; Genetic defect; Genetics, Population; Genome; Genome Instability; Genomic Instability; Genomics; Genotoxins; Impairment; In Vitro; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigation; Left; Life; Malignant Neoplasms; Malignant Tumor; Mathematical Model Simulation; Mathematical Models and Simulations; Models, Computer; Mutagens; Mutation; Natural Selections; Organism; Outcome; Physiologic; Physiological; Population; Population Biology; Population Genetics; Population Process; Population-Level Process; Process; Prokaryotae; Prokaryotic Cells; Public Health; Recombination; Recombination, Genetic; Relative; Relative (related person); Replication Process; Replication-Associated Process; Rest; Runaway; Selections, Natural; Simulation, Computer based; Solid; System; System, LOINC Axis 4; Taxon; Testing; Time; Variant; Variation; Virus; Viruses, General; Work; anti-microbial; antimicrobial; asexual; base; behavioral extinction; cancer progression; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; eukaryotida; experiment; experimental research; experimental study; facial; fitness; genetic analysis; genome mutation; genotoxic agent; in silico; innovate; innovation; innovative; interest; large scale simulation; living system; malignancy; microbial; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; pathogen; prokaryote; public health medicine (field); repair; repaired; research study; simulation; theories; tool; trait; treatment strategy; tumor progression; virtual simulation",Mutation rate catastrophe: testing a novel theory for the extinction of clonal or,,79483,GVE,Genetic Variation and Evolution Study Section,S1,2,212968,
8005923,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM079484-03S1,,NIGMS:120763;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IOWA CITY,UNITED STATES,BIOLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"LOGSDON, JOHN M;",1928999;,3R01GM079484,01/08/2010,12/31/2010,"Address; Alleles; Allelomorphs; Animals; Biological; Biology; Chromosome Pairing; Cloning; Collaborations; Cosmids; Detection; Disease; Disorder; Environment; Epidemiology; Eukaryota; Eukaryote; Evolution; Extinction; Extinction (Psychology); FISH Technic; FISH Technique; FISH analysis; Female; Fluorescent in Situ Hybridization; Fossils; Future; Gender Role; Gene Copy Number; Gene Dosage; Gene Transcription; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetics, Population; Genome; Genomics; Goals; Health; Homolog; Homologous Gene; Homologue; Human; Human, General; In Situ Hybridization, Fluorescence; Investigators; Iowa; Laboratories; Libraries; Location; MSH4; MSH4 gene; Man (Taxonomy); Man, Modern; Marines; Meiosis; Methods; Microscopic; Mitotic; Molecular Genetic; Molecular Genetics; Mutation; Organism; Ortholog; Orthologous Gene; Parasite resistance; Parthenogenesis; Pattern; Phylogenetic Analysis; Phylogenetics; Phylogeny; Play; Population Genetics; Programs (PT); Programs [Publication Type]; RNA Expression; RT-PCR; RTPCR; Relative; Relative (related person); Relaxation; Reproduction; Research; Research Personnel; Researchers; Retrotransposon; Reverse Transcriptase Polymerase Chain Reaction; Role; SEQ-AN; Sequence Analyses; Sequence Analysis; Sex Roles; Source; Survey Instrument; Surveys; Synapsis; Synapsis, Chromosomal; Taxon; Testing; Transcription; Transcription, Genetic; Universities; asexual; behavioral extinction; cDNA Library; disease/disorder; eukaryotida; fitness; genome mutation; living system; male; meiotic; paralog; paralogous gene; parasite resistant; pathogen; programs; reproductive; resistance to Parasite; resistant to Parasite; reverse transcriptase PCR; sex; social role",Meiotic genes in sexual and asexual rotifers,,79484,GVE,Genetic Variation and Evolution Study Section,S1,3,120763,
8006005,R01,GM,3,Y,01/22/2010,12/31/2010,,3R01GM079523-03S1,,NIGMS:127925;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SALT LAKE CITY,UNITED STATES,GENETICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"ATKINS, JOHN F.;",1968885;,3R01GM079523,01/22/2010,12/31/2010,"3-Selenylalanine; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bacteriophage T4; Base Sequence; Biological Models; Bypass; Cell Communication and Signaling; Cell Signaling; Code; Coding System; Codon; Codon Nucleotides; Codon, Nonsense; Codon, Stop; Codon, Termination; Codon, Termination, Premature; Codon, Terminator; Coliphage T4; Cryo-electron Microscopy; Cryoelectron Microscopy; DNA Alteration; DNA mutation; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Disease; Disorder; E coli release factor 2; E coli ribosomal release factor 2; Electron Cryomicroscopy; Embryo; Embryonic; Enterobacteria phage T4; Event; Fluorescence Spectroscopy; Frame Shift Mutation; Frameshift Mutation; Gagging; Gene Alteration; Gene Mutation; Gene Products, RNA; Genes; Genetic; Genetic mutation; Goals; HIV; HTLV-III; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Intracellular Communication and Signaling; Investigation; Kinetic; Kinetics; Knowledge; L-Alanine, 3-selenyl-; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice; Miscellaneous Antibiotic; Model System; Models, Biologic; Mouse Leukemia Viruses; Murine; Murine leukemia virus; Mus; Nonsense Codon; Nucleotide Sequence; Nucleotides; Peptide Biosynthesis, Ribosomal; Polyamine Compound; Polyamines; Premature Stop Codon; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Reading Frame Shift Mutation; Reading Frames; Reflex, Pharyngeal; Regulation; Resolution; Rf-2 E coli release factor; Ribonucleic Acid; Ribonucleic acids, transfer; Ribosomal Proteins; Ribosomes; SARS Virus; SARS coronavirus; SARS-Associated Coronavirus; SARS-CoV; SARS-Related Coronavirus; Scanning; Selenocysteine; Sequence Alteration; Severe Acute Respiratory Syndrome Virus; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spectroscopy, Fluorescence; Stop Signal, Translation; Structure; System; System, LOINC Axis 4; T4 Phage; Techniques; Terminator Codon; Testing; Transfer RNA; Translating; Translatings; Triplet Codon-Amino Acid Adaptor; Triplet Multiple Birth; Triplets; Urbani SARS-Associated Coronavirus; Viral; Virus-HIV; Work; biological signal transduction; clinical data repository; clinical data warehouse; cryoEM; data repository; design; designing; disease/disorder; flexibility; gene correction; gene product; gene-corrected; human disease; imprint; improved; insight; language translation; mRNA; mutant; novel; nucleic acid sequence; peptidyl-tRNA; programs; protein synthesis; relational database; release factor; response; single molecule; single-molecule FRET; single-molecule fluorescence resonance energy transfer; smFRET; structural biology; synthetic protein; tRNA; tRNA, peptidyl-",The range of recoding and analysis of a 50 nt bypass to probe ribosomal function,,79523,MGB,Molecular Genetics B Study Section,S1,3,127925,
8011924,R01,GM,3,Y,02/05/2010,01/31/2011,PA-07-070,3R01GM079529-01A2S1,,NIGMS:212328;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DETROIT,UNITED STATES,CHEMISTRY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"PFLUM, MARY KAY H;",2446301;,3R01GM079529,02/05/2010,01/31/2011,"ATP-protein phosphotransferase; ATP[{..}]adenosine 5'-phosphotransferase; Adenosine; Adenosine Kinase; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antioncogene Protein p53; Body Tissues; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Stress; Cellular Tumor Antigen P53; Cellular biology; Chemicals; Communication; D-Glyceraldehyde-3-phosphate[{..}]NADP+ oxidoreductase; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Targeting; Drug Targetings; Drugs; EC 2.7; Enzymes; Foundations; GAPD; Genes, p53; Glyceraldehyde-3-Phosphate Dehydrogenases; Glyceraldehydephosphate Dehydrogenase; Goals; HDAC1; HDAC1 protein, human; Histone Deacetylase 1; Intracellular Communication and Signaling; Kinases; Label; Lead; Malignant Neoplasms; Malignant Tumor; Mediating; Medication; Methods; Modification; Molecular; Monitor; Nucleotides; Oncoprotein p53; Outcome; P53; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphates; Phosphoglyceraldehyde Dehydrogenase; Phosphoprotein P53; Phosphoprotein pp53; Phosphoproteins; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Senile Degenerative Dementia; Protein Kinase; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein TP53; Protein p53; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RPD3L1 protein, human; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subcellular Process; TP53; TP53 gene; TRP53; Technology; Tissues; Transphosphorylases; Triosephosphate Dehydrogenase; Tumor Protein p53; Tumor Protein p53 Gene; Work; analog; base; biological signal transduction; cell biology; chemical addition; dementia of the Alzheimer type; disease/disorder; drug development; drug/agent; erythrocyte histone deacetylase 1, human; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human HDAC1 protein; hydroxyalkyl protein kinase; in vivo; inorganic phosphate; insight; malignancy; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; p53 Antigen; p53 Tumor Suppressor; phosphorylase b kinase kinase; primary degenerative dementia; public health relevance; research study; senile dementia of the Alzheimer type; social role; tool; triphosphate; tripolyphosphate",Chemical Approaches to Characterizing Kinase-catalyzed Modifications," Narrative Kinase enzymes are involved in various diseases and are the target of multiple pharmaceutical drugs. Kinases phosphorylate protein substrates, making a characterization of phosphoproteins an important aspect of health-related research. The application outlines new approaches to characterizing kinase substrates and kinase-catalyzed modifications to aid in the understanding of disease and development of new treatments.",79529,SBCB,Synthetic and Biological Chemistry B Study Section,A2S1,1,212328,
8006014,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM079535-03S1,,NIGMS:93491;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"MOAZED, DANESH ;",1944254;,3R01GM079535,01/08/2010,12/31/2010,"2PP2A; Adaptor Protein; Adaptor Signaling Protein; Affinity Chromatography; Binding; Binding (Molecular Function); Biochemistry; Cancers; Cell Nucleolus; Cells; Chemistry, Biological; Chromatids; Chromatin Structure; Chromatography, Affinity; Chromosomal Instability; Chromosomal Organization; Chromosomal Stability; Chromosomal Structure; Chromosome Instability; Chromosome Organization; Chromosome Structures; Complex; DNA; DNA Maintenance; DNA Recombination; DNA Sequence; DNA Stability; DNA recombination (naturally occurring); DNA-Dependent RNA Polymerase II; Deacetylation; Deoxyribonucleic Acid; Disease; Disorder; Endomycetales; Ensure; Envelope Protein; Eukaryota; Eukaryote; Event; Gene Inactivation; Gene Products, env; Gene Silencing; Gene Transcription; Generalized Growth; Genes, rRNA; Genetic Recombination; Genetic Transcription; Genome; Goals; Growth; HLA-DR Associated Protein II; Human; Human, General; I2PP2A; IGAAD; In Vitro; Inhibitor of GZMA-Activated DNase; Integral Membrane Protein; Intrinsic Membrane Protein; Investigators; Laboratories; Lead; Link; M Phase; M phase (cell cycle); Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Meiotic Recombination; Membrane Proteins; Membrane-Associated Proteins; Mitosis; Mitosis Stage; Mitotic; Molecular; Molecular Biology, Recombinant DNA; Molecular Interaction; Nature; Nuclear; Nuclear Envelope; Nuclear Membrane; Nuclear Protein; Nuclear Proteins; PHAPII; Pb element; Phosphatase 2A Inhibitor I2PP2A; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Photometry/Spectrum Analysis, Mass; Plasmosome; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Analysis; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Proteins; Proteomics; RNA Expression; RNA Polymerase B; RNA Polymerase II; Recombinant DNA; Recombination; Recombination, Genetic; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Ribosomal RNA Genes; Role; S cerevisiae; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; SIS; Saccharomyces cerevisiae; Saccharomycetales; Set protein; Sister; Sister Chromatid; Slide; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stabilities, Chromosome; Surface Proteins; TAF-IBETA; Template Activating Factor I Beta; Testing; Therapeutic; Tissue Growth; Transcription; Transcription, Genetic; Transmembrane Protein; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; affinity purification; cohesin; cohesion; design; designing; disease/disorder; env Antigens; env Gene Products; env Polyproteins; env Protein; eukaryotida; gene product; heavy metal Pb; heavy metal lead; homologous recombination; in vivo; insight; malignancy; neoplasm/cancer; nucleolus; ontogeny; prevent; preventing; programs; protein protein interaction; rDNA; rRNA Genes; role model; social role; stoichiometry",Regulation of rRNA Genes by Silencing Mechanisms,,79535,MGB,Molecular Genetics B Study Section,S1,3,93491,
8006169,R01,GM,3,Y,01/15/2010,12/31/2010,,3R01GM079641-03S1,,NIGMS:76776;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GOZANI, OR P.;",1911911;,3R01GM079641,01/15/2010,12/31/2010,"Acute; Affinity; Amino Acid Motifs; Binding; Binding (Molecular Function); Biochemical; Biological; Biological Function; Biological Process; Biology; C4HC3 Zinc Finger; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chromatin; Complex; DNA Damage; DNA Injury; Deacetylase; Disease; Disorder; EC 2; Family; Gene Down-Regulation; Gene Expression; Gene Targeting; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetics, Other; Genotoxic Stress; Goals; Growth; HDAC; HDAC Proteins; Hereditary Disease; Histone Deacetylase; Histone H3; Histones; Homeo Domain; Human; Human, General; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunodeficiency and Cancer; Immunoglobulin V(D)J Rearrangement; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; L-Lysine; Lead; Link; Lipids; Lysine; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mental Retardation; Methylation; Modeling; Modification; Molecular; Molecular Disease; Molecular Interaction; Mono-S; MonoS; Multienzyme Complexes; Mutation; Nuclear; Other Genetics; Outcome; PHD Finger; PHD Finger Motif; PTDINS5P; Pathologic; Pb element; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Physiologic; Physiological; Plant Homeodomain Type Zinc Finger; Plants; Plants, General; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Motifs; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; PtdIns; PtdIns-5-P; Recruitment Activity; Regulation; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stress, Genotoxic; Subcellular Process; Syndrome; Targetings, Gene; Testing; Tissue Growth; Transcription Repression; Transcriptional Repression; Transferase; Tumor Suppressor Proteins; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; Work; base; biological signal transduction; disease/disorder; enzyme complex; gene product; gene repression; genetic disorder; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; homeodomain; human disease; hypoimmunity; immune deficiency disorder; immunodeficiency; in vitro activity; insight; malignancy; member; neoplasm/cancer; novel; ontogeny; phosphatidylinositol 5-phosphate; programs; recombinase; recruit; response; social role; tumor suppressor",Function of ING PHD domains in chromatin regulation,,79641,MGC,Molecular Genetics C Study Section,S1,3,76776,
8006530,R01,GM,3,Y,01/08/2010,12/31/2010,,3R01GM079682-03S1,,NIGMS:110811;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AURORA,UNITED STATES,BIOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"EVANS, THOMAS C;",1869839;,3R01GM079682,01/08/2010,12/31/2010,"3' Untranslated Regions; 3'UTR; Address; Affinity; Animals; Antibodies; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complex; Cytoplasm; Cytoplasmic Granules; Defect; Degradation, mRNA; Detection; Development; Disease; Disorder; Elements; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Event; Gene Probes, RNA; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic Translation; Genetic defect; Germ; Germ Lines; Gonadal structure; Gonads; Growth and Development; Growth and Development function; Human; Human, General; In Situ; In element; Indium; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Lead; Life; Link; Malignant Neoplasms; Malignant Nervous System Neoplasm; Malignant Tumor; Malignant Tumor of the Nervous System; Man (Taxonomy); Man, Modern; Maternal Messenger RNA; Maternal mRNA; Mediating; Messenger RNA; Methods; Molecular; Molecular Interaction; Mutation; Nematoda; Nematodes; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Oocytes; Oogenesis; Organism; Ovocytes; Pb element; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Proteins; Public Health; Quelling; RNA; RNA Interference; RNA Probes; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Non-Polyadenylated; RNAi; Regulation; Reporter; Repression; Research Personnel; Researchers; Ribonucleic Acid; Ribosomes; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stress; Subcellular Process; Translating; Translatings; Translational Inhibition; Translational Repression; Translations; UTRs; Untranslated Regions; Work; biological signal transduction; cell determination; disease/disorder; gene product; genome mutation; granule; heavy metal Pb; heavy metal lead; in vivo; insight; language translation; living system; mRNA; mRNA Transcript Degradation; mRNA Translation; malignancy; malignant neurologic neoplasms; mutant; neoplasm/cancer; nervous system disorder; neurological disease; new approaches; notch; notch protein; notch receptors; novel; novel approaches; novel strategies; novel strategy; particle; programs; protein complex; protein function; protein structure; public health medicine (field); roundworm; social role",Regulation of mRNPs during early C. elegans development,,79682,DEV1,Development - 1 Study Section,S1,3,110811,
8004618,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM080505-02S1,,NIGMS:99130;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"WEISS, MICHAEL AARON;",1863443;,3R01GM080505,01/08/2010,12/31/2010,"0-6 weeks old; 21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Abbreviations; Address; Admixture; Adult; Alleles; Allelomorphs; Animals; Behavior; Behavioral; Behavioral Genetics; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Biological; Biological Function; Biological Process; Birth Defects; Body Tissues; C 1 Esterase; C elegans; C-terminal; C.elegans; C1 Esterase; C1 s; C1s; Caenorhabditis elegans; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Chemistry, Biological; Chromosome 9; Chromosomes, Human; Chromosomes, Human, Pair 9; Co-Immunoprecipitations; Collaborations; Complement 1 Esterase; Complement 1s; Complement component C1s; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Coupled; Courtship; DNA; DNA Binding; DNA Binding Interaction; DNA Sequencing Facility; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Developmental Biology; Difficulty conceiving; Dimerization; Disease; Disorder; Drosophila; Drosophila genus; Drosophila melanogaster; E2A; E2A Immunoglobulin Enhancer Binding Factor E12; E2A Immunoglobulin Enhancer Binding Factor E47; Elements; Exhibits; Family; Female; Flies; Foundations; Fruit Fly, Drosophila; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genes, Homeo Box; Genes, Homeobox; Genetic; Genetic Alteration; Genetic Change; Genetic Determinants of Behavior; Genetic Transcription; Genetic analyses; Genetic defect; Genetics, Behavioral; Goals; H+ element; HMG-20; HOX gene; Hand; High Mobility Protein 20; Homeobox Family Gene; Homeobox Genes; Homeodoamin Gene; Homeotic Genes; Human; Human Chromosomes; Human, Adult; Human, General; Hybrids; Hydrogen Ions; ITF1; Immunoglobulin Transcription Factor 1; In Vitro; In element; Indium; Infant, Newborn; Infertility; Intracellular Communication and Signaling; Isoforms; Kappa-E2-Binding Factor; Laboratories; Location; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediating; Methods; Modeling; Molecular; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Molecular Interaction; Mutation; N-terminal; NH2-terminal; NOE; NRVS-SYS; Nervous System; Nervous system structure; Neurologic Body System; Neurologic Organ System; Newborn Infant; Newborns; Nuclear Magnetic Resonance; Phenotype; Photometry/Spectrum Analysis, Mass; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding; Protein Dimerization; Protein Isoforms; Proteins; Proteomics; Protons; RNA Expression; RNA Splicing; Regulation; Research; Resolution; Screening procedure; Sequencing Core; Sexual Development; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specific qualifier value; Specified; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Staging; Structure; Structure-Activity Relationship; Syndrome; System; System, LOINC Axis 4; TCF3; Tail; Targetings, Gene; Technology; Temperature; Tissues; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor 3; Transcription Factor Coactivator; Transcription Factor E2-Alpha; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenes; Transgenic Organisms; Two Hybrid; Ubiquitin; Validation; Variant; Variation; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adult human (21+); base; behavior genetics; biological signal transduction; chemical structure function; clinical data repository; clinical data warehouse; data repository; design; designing; dimer; disease/disorder; fly; fruit fly; gel mobility shift assay; gene product; genetic analysis; genome mutation; gonadal cancer; in vivo; infertile; innovate; innovation; innovative; insight; intercellular communication; loss of function; male; member; neural circuit; neural circuitry; newborn human (0-6 weeks); nuclear Overhauser enhancement; null mutation; programs; protein function; protein protein interaction; protein structure; public health relevance; relational database; screening; screenings; sex; sex determination; sex development; sex dimorphism; sexual dimorphism; structural biology; structure function relationship; trait; transcription factor; transgenic; unable to bear children; yeast two hybrid system",Biochemical Studies of a Transcription Factor,,80505,DEV2,Development - 2 Study Section,S1,2,99130,
8008962,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM080506-02S1,,NIGMS:40318;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"SHEA, KENNETH J;",1883875;,3R01GM080506,01/28/2010,12/31/2010,"Affinity; Amino Acid Sequence; Amino Acids; Animals; Antibodies; Antibody-Producing Cells; Antigenic Determinants; Binding; Binding (Molecular Function); Binding Determinants; Bio-Informatics; Bioinformatics; Biological; Biomedical Research; Biosensor; Blood Plasma; Buffers; Cancers; Cell Line; Cell Lines, Strains; CellLine; Characteristics; Cherries; Cherry - dietary; Clinical; Collaborations; Complex; DNA; Deoxyribonucleic Acid; Development; Diagnostic; Dialysis; Dialysis procedure; Disease; Disorder; Enzymes; Epitopes; Exhibits; Film; Gamma Globulin, 7S; Genomics; Glass; Goals; IgG; Immunoglobulin G; Immunoglobulin-Producing Cells; In Vitro; Infection; Institutes; Lead; Length; Life; Malignant Neoplasms; Malignant Tumor; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Pb element; Peptide Domain; Peptide Fragments; Peptide Receptor; Peptides; Performance; Plasma; Plastics; Polymers; Precipitation; Preparation; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Domains; Protein Structure Databases; Protein Structure, Primary; Proteins; Quartz; Quartz (SiO2); Reaction; Reagent; Receptor Protein; Research; Reticuloendothelial System, Serum, Plasma; Serum, Plasma; Si element; Silicon; Site; Solutions; Specificity; Structure; Structure Databases, Protein; Surface; Suspension substance; Suspensions; System; System, LOINC Axis 4; Techniques; Tertiary Protein Structure; Therapeutic; Toxin; abstracting; aminoacid; aminoacid sequence of peptide; aminoacid sequence of protein; analytical tool; base; biomarker; cost; cultured cell line; design; designing; dialysis therapy; disease diagnosis; disease/disorder; gene product; heavy metal Pb; heavy metal lead; imprint; macromolecule; malignancy; monomer; nano particle; nano sized; nanoparticle; nanosized; neoplasm/cancer; particle; peptide sequence; peptide structure; polymerization; professor; programs; protein aminoacid sequence; protein purification; protein sequence; protein structure; receptor; sensor (biological); suspension",Selective Protein Capture by Epitope Imprinting," Project Narrative  Antibodies are important reagents that are used in biomedical research, in diagnosis of diseases, and in treatment of such diseases as infections and cancer. Antibodies are produced by cell lines or clones obtained from animals that have been immunized with the substance that is the target of study. We propose to develop a method for producing robust, inexpensive, non-biological polymer antibodies that can be used as substitutes for native antibodies.",80506,SBCA,Synthetic and Biological Chemistry A Study Section,S1,2,40318,
8006596,R01,GM,3,Y,01/15/2010,12/31/2010,,3R01GM080527-04S1,,NIGMS:86980;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,OBSTETRICS & GYNECOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"CONTI, MARCO ;",1900280;,3R01GM080527,01/15/2010,12/31/2010,"3'5'-cyclic ester of AMP; Ablation; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Alleles; Allelomorphs; Biochemical; CDC25B; Cdc25B protein; Cell Communication; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotides; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7; Environment; Enzymes; Female; Female infertility; G2/M Transition; Gametes; Genetic Models; Germ Cells; Germ-Line Cells; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Laboratories; Ligands; Light; Maintenance; Maintenances; Mammals, Mice; Mediating; Meiosis; Mice; Modeling; Models, Genetic; Murine; Mus; Mutagenesis, Site-Directed; Nucleotides, Cyclic; Oocytes; Ovocytes; PKA; Pathway interactions; Pattern; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photoradiation; Process; Production; Property; Property, LOINC Axis 2; Protein Kinase A; Protein Phosphorylation; Regulation; Reproductive Cells; Role; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Somatic Cell; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Transphosphorylases; adenosine 3'5' monophosphate; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cdc25B gene product; cdc25B phosphatase; granulosa cell; in vivo; initial cell; meiotic; oocyte maturation; paracrine; pathway; reconstitute; reconstitution; sexual cell; social role; tool",Cyclic AMP and the Control of the Meiotic Cell Cycle,,80527,ZRG1,Special Emphasis Panel,S1,4,86980,
8009924,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM080670-03S1,,NIGMS:34471;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"ZHAO, XIAOLAN ;",8689841;,3R01GM080670,01/08/2010,12/31/2010,"APF-1; ATP phosphohydrolase; ATP-Dependent Proteolysis Factor 1; ATPase; Aberrant Chromosome; Abnormalities, Chromosomal; Abscission; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Behavior; Biochemical; Biological; Cancers; Cell Cycle Arrest; Cells; Characteristics; Chromatids; Chromatin; Chromosomal Aberrations; Chromosomal Alterations; Chromosomal Organization; Chromosomal Structure; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome Organization; Chromosome Structures; Chromosome abnormality; Chromosomes; Complex; Cruciform DNA; Cytogenetic Aberrations; Cytogenetic Abnormalities; DNA Recombination; DNA Replication; DNA Structure; DNA Synthesis; DNA biosynthesis; DNA recombination (naturally occurring); DNA, Cruciform; Data; Defect; Double Strand Break Repair; Endomycetales; Event; Excision; Exhibits; Extirpation; FLR; Face; Failure (biologic function); Family; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Genome Instability; Genomic Instability; Goals; Grant; HMG-20; High Mobility Protein 20; Holliday Junction DNA; Holliday Junctions; Homologous Recombinational Repair; Human; Human, General; Laboratories; Lead; Lesion; Ligase; Literature; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Molecular; Molecular Dynamics Simulation; Mutation; Nature; Nuclear; Pathway interactions; Pb element; Play; Postdoc; Postdoctoral Fellow; Process; Programs (PT); Programs [Publication Type]; Protein Dynamics; Proteins; Racial Segregation; Recombination; Recombination Repair; Recombination, Genetic; Recovery; Removal; Research; Research Associate; Role; Saccharomycetales; Single Strand Break Repair; Sister Chromatid; Structure; Surgical Removal; Synthetases; Ubiquitin; Work; Yeast, Budding; cohesin; cohesion; condensin; coping; facial; failure; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; insight; malignancy; member; molecular dynamics; mutant; neoplasm/cancer; pathway; post-doc; post-doctoral; programs; protein complex; protein function; recombinational repair; repair; repaired; resection; segregation; social role",Studies of the Smc5/Smc6 complex in chromosomal replication,,80670,MGA,Molecular Genetics A Study Section,S1,3,34471,
8010022,R01,GM,3,Y,01/08/2010,12/31/2010,PA-07-070,3R01GM081422-02S1,,NIGMS:124975;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,BIOCHEMISTRY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"RYDER, SEAN PATRICK;",8751549;,3R01GM081422,01/08/2010,12/31/2010,"21+ years old; 3' Untranslated Regions; 3'UTR; Adult; Affinity; Animals; Anterior; Arthritis; Assay; Atrophic Arthritis; Autoimmune Diseases; Base Sequence; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blastocytes; Blastomere; Blastomeres; C elegans; C.elegans; Caenorhabditis elegans; Cannot achieve a pregnancy; Cell Growth and Maintenance; Cell Maintenance; Cells; Central Nervous System; Cognitive Discrimination; Combining Site; Complex; Consensus; Consensus Sequence; ConsensusSequence; Contraception; Contraceptive methods; Defect; Development; Difficulty conceiving; Discrimination; Discrimination (Psychology); Distal; Elements; Embryo; Embryo Development; Embryo stage 2; Embryogenesis; Embryonic; Embryonic Cell; Embryonic Development; Fertility Control; Fertilized Egg; Fertilized Ovums; Functional RNA; GLP-1; Gametogenesis; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic Translation; Genetic defect; Goals; Homolog; Homologous Gene; Homologue; Human Biology; Human Development; Human, Adult; INFLM; Immune Precipitation; Immunity; Immunoprecipitation; In Vitro; In element; Indium; Individual; Infertility; Inflammation; Inflammatory; Inflammatory Arthritis; Inhibition of Fertilization; K Homology Domain; KH Domain; Knowledge; Lead; Learning; Life; MS (Multiple Sclerosis); Mammalia; Mammals; Mammals, General; Maternal Messenger RNA; Maternal mRNA; Measures; Mental disorders; Mental health disorders; Messenger RNA; Methods; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Mother Cells; Multiple Sclerosis; Mutation; Nematoda; Nematodes; Nervous System Diseases; Nervous System, CNS; Neuraxis; Neurologic Disorders; Neurological Disorders; Non-Coding; Non-Coding RNA; Nucleotide Sequence; Nucleotides; Oocytes; Organism; Ovocytes; Ovum, Fertilized; Pattern; Pb element; Phenotype; Play; Position; Positioning Attribute; Process; Progenitor Cells; Proteins; Psychiatric Disease; Psychiatric Disorder; RNA; RNA Binding; RNA Expression; RNA Sequences; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Binding Proteins; Reactive Site; Regulation; Regulatory Protein; Reporter; Rheumatoid Arthritis; Ribonucleic Acid; Role; Sclerosis, Disseminated; Sequences, RNA; Site; Specificity; Staging; Stem cells; Stretching; Structure of blastomere; Structure of embryo stage 2; Structure of zygote; Testing; Therapeutic; Thermodynamic; Thermodynamics; Transcript; Transcription; Transcription, Genetic; Transgenic Organisms; Translations; Unspecified Mental Disorder; Urd; Uridine; Vascularization; Work; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; Zygote; adult human (21+); arthritic; autoimmune disorder; base; blastomere structure; cell fate specification; combat; cross-link; crosslink; embryo stage 2; experiment; experimental research; experimental study; gene product; genetic regulatory protein; genome mutation; glucagon-like peptide 1; heavy metal Pb; heavy metal lead; in vivo; infertile; insular sclerosis; living system; mRNA; mRNA Translation; mental illness; mutant; myelination; nervous system disorder; neurological disease; notch; notch protein; notch receptors; novel; nucleic acid sequence; pleiotropism; pleiotropy; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; psychological disorder; regulatory gene product; research study; response; roundworm; social role; stem; transgenic; unable to bear children; zygote",RNA recognition by maternal gene silencers in nematodes,,81422,MGA,Molecular Genetics A Study Section,S1,2,124975,
8007522,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM081603-03S1,,NIGMS:75039;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LIU, JING ;",8776741;,3R01GM081603,01/20/2010,12/31/2010,"ATP-protein phosphotransferase; Affect; Apoptosis; Apoptosis Pathway; Architecture; Biochemical; Biological Function; Biological Process; Cancers; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cues; DIF; Data; Development; Diabetes Mellitus; EC 2.7; EC 2.7.2-; Embryo Development; Embryogenesis; Embryonic Development; Engineering / Architecture; Event; Extracellular Signal-Regulated Kinases; Genetic; Goals; Heart Hypertrophy; Human; Human, General; INFLM; Immune response; Inflammation; Intracellular Communication and Signaling; Isoforms; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Kinases; Knock-out; Knockout; MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; MGC[{..}]45012; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mitogen-Activated Protein Kinases; Molecular; N-terminal; NH2-terminal; Obesity; Oncogenesis; PRKM8; PRKM9; Pathway interactions; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Play; Prevention; Protein Isoforms; Protein Kinase; Protein Phosphorylation; Proteins; Recruitment Activity; Regulation; Research; Role; SAPK; SAPK1; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stimulus; Stress; TNF; TNF A; TNF gene; TNFSF2; TRAF2; TRAF2 gene; TRAP3; Therapeutic; Transphosphorylases; Tumor Necrosis Factor Gene; Two Hybrid; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adiposity; biological signal transduction; c jun; c-jun Gene; cancer type; cardiac hypertrophy; corpulence; corpulency; corpulentia; diabetes; extracellular; gene product; glycogen synthase a kinase; host response; human disease; hydroxyalkyl protein kinase; immunoresponse; malignancy; necrocytosis; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; p54aSAPK; pathway; phosphorylase b kinase kinase; protein complex; public health relevance; recruit; response; screening; screenings; social role; stress activated protein kinase; tumorigenesis; ubiquination; ubiquitin conjugation; yeast two hybrid system",The JNK Signalsome and its Functions,,81603,ZRG1,Special Emphasis Panel,S1,3,75039,
8009181,R01,GM,3,,12/01/2009,11/30/2010,PA-07-070,3R01GM081666-02S1,,NIGMS:59506;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,BIOCHEMISTRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"OAS, TERRENCE GILBERT;",1867248;,3R01GM081666,12/01/2008,11/30/2012,"3-D structure; 3-dimensional structure; 3D structure; Acids; Algorithms; Amino Acids; Antibodies; Bacteria; Behavior; Binding; Binding (Molecular Function); Biologic Phenomena; Biological; Biological Models; Biological Phenomena; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complement; Complement Proteins; Complex; Coupled; Coupling; Data; Dependence; Disease; Disorder; Electrostatics; Environment; Equilibrium; FRET; Fluorescence; Fluorescence Resonance Energy Transfer; Gamma Globulin, 7S; Gene Products, RNA; Glycine cleavage system P-protein; Glycine dehydrogenase (decarboxylating); Goals; H+ element; HMG-I; HMG-I/Y; HMGA1; HMGA1a; HMGI; Hand; Holoenzymes; Hydrogen Ions; IgG; Immunoglobulin G; In Vitro; Kinetic; Kinetics; L-Methionine; Laboratories; Length; Ligand Binding; Ligands; Measurement; Measures; Mechanics; Methionine; Methionine, L-Isomer; Methods; Model System; Modeling; Models, Biologic; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; N-terminal; NH2-terminal; P-protein; P-protein, glycine decarboxylase; Pathogenicity Factors; Peptide Domain; Physiologic; Physiological; Play; Process; Property; Property, LOINC Axis 2; Protein Domains; Protein Secretion; Proteins; Protons; RNA; RNA, Non-Polyadenylated; RNase P; Reaction; Recurrence; Recurrent; Regulation; Relaxation; Research; Rest; Ribonuclease P; Ribonucleic Acid; Role; S. aureus; S. aureus protein A; S.aureus; Sampling; Side; Staph. Protein A; Staphylococcal Protein A; Staphylococcus aureus; Staphylococcus aureus Protein A; Subcellular Process; System; System, LOINC Axis 4; Tertiary Protein Structure; Thermodynamic; Thermodynamics; Time; Virulence Factors; Work; aminoacid; balance; balance function; base; conformation; conformational state; design; designing; disease/disorder; driving force; experiment; experimental research; experimental study; gene product; glycine decarboxylase; insight; knowledge base; oxidation; protein complex; protein folding; protein function; public health relevance; research study; small molecule; social role; stopped-flow fluorescence; temperature jump; three dimensional structure",Mechanistic Studies of Complex Protein Folding Reactions," Project Narrative These studies are important because many protein domains have been observed to sample their unfolded states tens or hundreds of times every second, making the unfolded form as relevant to function as the folded form. The biological significance of our proposed studies rests on the relevance of recurrent and complex folding reactions to the regulation and function of proteins in the cell. A detailed understanding of protein-ligand interactions and the myriad biological phenomena that result from them requires a thermodynamic and kinetic description.",81666,MSFB,Macromolecular Structure and Function B Study Section,S1,2,59506,
8007525,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM083048-03S2,,NIGMS:116102;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,GENETICS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"AHMED, SHAWN CAMERON;",1968122;,3R01GM083048,01/20/2010,12/31/2010,"Affect; Age; Aging; Alleles; Allelism Test; Allelomorphs; Animals; Biological; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cell Body; Cells; Complementation Test; Disease; Disorder; Ensure; Gametes; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Complementation Test; Genetic analyses; Genetic defect; Genetics-Mutagenesis; Germ; Germ Cells; Germ-Line Cells; Germ-Line Mutation; Germline Mutation; Goals; Hereditary Mutation; Human; Human, General; Length of Life; Longevity; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mitotic; Molecular; Molecular Biology, Mutagenesis; Mother Cells; Mutagenesis; Mutation; Nature; Network Analysis; Oncogenesis; Oocytes; Ovocytes; Pathway Analysis; Pathway interactions; Pattern; Phenotype; Polymorphism, Single Base; Position; Positioning Attribute; Progenitor Cells; Proteins; Reproductive Cells; Resolution; SEQ-AN; SNP; SNPs; Senescence; Sequence Analyses; Sequence Analysis; Sex Cell; Single Nucleotide Polymorphism; Somatic Cell; Sperm; Spermatozoa; Stem cells; Sterility; Telomerase; Temperature; Testing; Time; Tissues; Trans Test; Work; X Chromosome; age dependent; age related; autosome; base; cell body (neuron); design; designing; disease/disorder; gene function; gene product; genetic analysis; genome mutation; in vivo; initial cell; life span; lifespan; malignancy; mutant; neoplasm/cancer; neural cell body; neuronal cell body; pathway; prevent; preventing; senescent; sexual cell; soma; sperm cell; stem; sterile; tumorigenesis; zoosperm",Genetic Analysis of Germ Cell Immortality,,83048,CMAD,Cellular Mechanisms in Aging and Development Study Section,S2,3,116102,
8007526,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM083071-02S1,,NIGMS:100000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"GOLDSTEIN, ROBERT PATRICK;",1923187;,3R01GM083071,01/20/2010,12/31/2010,"3p- syndrome; Actomyosin; Adhesions; Animals; Apical; Assay; Behavior; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brachydanio rerio; C elegans; C.elegans; Cadherins; Caenorhabditis elegans; Cancers; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Matrix; Cellular Migration; Child Development Disorders, Specific; Complex; Cytoskeletal System; Cytoskeleton; DISSEC; Danio rerio; Defect; Development; Developmental Defects, Neural Tube; Developmental Delay; Developmental Delay Disorders; Disease; Disorder; Dissection; Drosophila; Drosophila genus; Enhancers; Eye diseases; F3 protein; Fruit Fly, Drosophila; Funding; Future; GeneHomolog; Genes; Genetic; Goals; Grant; Homolog; Homologous Gene; Homologue; Human; Human, General; Intracellular Communication and Signaling; Lateral; Lead; Life; Link; Liver Cell Adhesion Molecules; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Modeling; Molecular; Morphogenesis; Motility; Motility, Cellular; Neural Tube Closure; Neural Tube Defects; Neural tube; Organ; Organism; Pattern; Pb element; Peptide Domain; Phenotype; Play; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Domains; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Research; Role; Sequence-Specific Posttranscriptional Gene Silencing; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Skin; Study models; System; System, LOINC Axis 4; Tertiary Protein Structure; Testing; Tissues; Work; Xenopus; Zebra Danio; Zebra Fish; Zebrafish; base; biological signal transduction; cell motility; chromosome 3p deletion syndrome; chromosome 3p monosomy; congenital cardiac disorder; congenital heart disease; congenital heart disorder; contactin; contactin 1; del(3p) syndrome; deletion 3p syndrome; disease/disorder; expectation; eye disorder; fruit fly; gastrulation; gene function; gene product; heavy metal Pb; heavy metal lead; human disease; imaging modality; improved; insight; interest; intracellular skeleton; liver cell adhesion molecule; living system; loss of function; malignancy; microphthalmia with linear skin defects; microphthalmia with linear skin defects (MLS); microphthalmia-dermal aplasia-sclerocornea (MIDAS) syndrome; microphthalmia-dermal aplasia-sclerocornea syndrome; monosomy 3p; neoplasm/cancer; neuronal cell surface protein F3; novel; ophthalmopathy; partial monosomy 3p; precursor cell; protein function; rho; rho GTPase-activating protein; rhoGAP; social role",Mechanisms of C. elegans Gastrulation,,83071,DEV1,Development - 1 Study Section,S1,2,100000,
8007529,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM084020-01A1S1,,NIGMS:127981;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,FORT COLLINS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,04,785979618,US,CO,80523,COLORADO STATE UNIVERSITY-FORT COLLINS,"NICKOLOFF, JAC A;",1867941;,3R01GM084020,01/20/2010,12/31/2010,"AT-V1 Gene; AT-V2 Gene; ATV Gene; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Cancer Cause; Cancer Etiology; Cancer Treatment; Cancers; Cell Function; Cell Process; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Stress Response; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Chromosomal dislocation; Chromosomal translocation; Chromosomes; Combination Chemotherapy Regimen; DNA; DNA Damage; DNA Double Strand Break; DNA Injury; DNA Integration; DNA ligase IV; DNA, Viral; DNA-PKcs; Defect; Deoxyribonucleic Acid; Development; Double Strand Break Repair; EC 2.1.1; EC 2.7; Elements; Fostering; Gene Targeting; Gene Therapy Agent; Genetics-Mutagenesis; Genome; Genome Instability; Genome, Human; Genomic Instability; Human; Human Genome; Human, General; Hydroxycarbamid; Hydroxycarbamide; I-SceI; In Vitro; Kinases; L-Lysine; L-Serine; Ligase; Lysine; Maintenance; Maintenances; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mesilate, Methyl; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methanesulfonic acid, methyl ester; Methyl Mesylate; Methyl Methanesulfonate; Methyl Methylenesulfonate; Methylmesilate; Methylmethane Sulfonate; Methyltransferase; Modification; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; NALP2; NBS Gene; NBS1; NBS1 gene; NHEJ; Neoplasm Metastasis; Nibrin Gene; Nijmegen Breakage Syndrome 1 Gene; Non-Homologous End Joining; Nonhomologous DNA End Joining; PYPAF2; Phase; Phosphorylation; Phosphotransferases; Plasmids; Process; Proliferating; Protein Phosphorylation; Proteins; Quimioterapia; RNA, Small Interfering; Role; SceI endonuclease; Secondary Neoplasm; Secondary Tumor; Serine; Site; Small Interfering RNA; Stress; Subcellular Process; Synthetases; System; System, LOINC Axis 4; Targetings, Gene; Testing; Tissues; Translocation, Genetic; Transphosphorylases; Transposase; Tumor Cell Migration; Urea, hydroxy-; Viral; XRCC4; XRCC4 gene; anticancer therapy; base; cancer chemotherapy; cancer initiation; cancer metastasis; cancer radiation therapy; cancer therapy; cell growth; chemotherapy; chromosome dislocation; chromosome translocation; endo.SceI; endodeoxyribonuclease Sce I; endodeoxyribonuclease SceI; gene product; homologous recombination; human disease; human tissue; hydroxyurea; in vivo; inhibitor; inhibitor/antagonist; insight; leukemia/lymphoma; lymphoma/leukemia; malignancy; meganuclease I-SceI; methylase; neoplasm/cancer; nuclease; public health relevance; siRNA; social role; transmethylase; treatment strategy; viral DNA; virus DNA","METNASE ROLES IN NHEJ, DNA INTEGRATION AND TRANSLOCATION"," Project Narrative The human protein Metnase functions in DNA double-strand break repair, DNA integration into the human genome, and chromosomal translocations. The proposed studies will provide mechanistic information about cellular functions of Metnase. This information will provide new insights into cellular stress responses and the maintenance of genome integrity, both of which are important for cancer initiation and progression, and for cancer treatment. The proposed studies are also relevant to mechanisms of genome modification (mutagenesis) by viral and non-viral DNA insertion, and chromosomal translocations in human diseases including leukemias and lymphomas. Mechanistic insights into these processes will foster development of more effective and safer cancer radio- and chemotherapy protocols, anti-viral agents, and gene therapy systems.",84020,RTB,Radiation Therapeutics and Biology Study Section,A1S1,1,127981,
8007534,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM084034-02S1,,NIGMS:49900;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LYNCH, KRISTEN W;",1878362;,3R01GM084034,01/20/2010,12/31/2010,"Alternate Splicing; Alternative Splicing; Amino Acid Sequence; Amino Acid Sequence Analysis; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bio-Informatics; Bioassay; Biochemical; Bioinformatics; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Data; Dependence; Elements; Environment; Event; Exclusion; Exons; Future; Gene Action Regulation; Gene Cluster; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Splicing; Genes; Genetics-Mutagenesis; Goals; Heterogeneous-Nuclear Ribonucleoprotein L; Human; Human, General; Immune system; Intracellular Communication and Signaling; Investigation; Isoforms; Laboratories; Ligand Binding Protein; Man (Taxonomy); Man, Modern; Mediating; Methods; Molecular; Molecular Biology, Mutagenesis; Molecular Biology, Protein Sequencing; Molecular Interaction; Mutagenesis; Pathway interactions; Pattern; Peptide Sequence Analysis; Peptide Sequence Determination; Pre-mRNA; Prevention; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Isoforms; Protein Sequence Analysis; Protein Sequencing; Protein Structure, Primary; Proteins; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger, Precursors; RNA-Binding Proteins; Regulation; Regulatory Protein; Research; SEQ-AN; Sequence Analyses; Sequence Analyses, Amino Acid; Sequence Analyses, Peptide; Sequence Analyses, Protein; Sequence Analysis; Sequence Analysis, Protein; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Sequence Homology; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spliced Genes; Splicing; Stimulus; Subcellular Process; T-Cell Activation; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; base; biological signal transduction; body system, allergic/immunologic; combinatorial; cultured cell line; environmental change; experiment; experimental research; experimental study; gene product; genetic regulatory protein; hnRNP L; homology (molecular); human disease; in vitro Assay; insight; mRNA Precursor; novel; organ system, allergic/immunologic; pathway; premRNA; programs; protein activation; protein function; protein sequence; regulatory gene product; research study; response; thymus derived lymphocyte",Coordination of Inducible Alternative Splicing Networks in Human T Cells,,84034,MGA,Molecular Genetics A Study Section,S1,2,49900,
8000241,R01,GM,3,Y,01/29/2010,12/31/2010,PA-07-070,3R01GM084210-02S1,,NIGMS:31500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"GOODMAN, JOEL M;",1882770;,3R01GM084210,01/29/2010,12/31/2010,"3T3-L1 Cells; Acyl CoA; Acyl Coenzyme A; Adipocytes; Adipose Cell; Adipose tissue; Affect; Apoplexy; Assay; BSCL2 protein, human; Bernardinelli-Seip congenital lipodystrophy 2, human; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Caloric Intake; Cardiac Diseases; Cardiac Disorders; Cell model; Cells; Cellular model; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Co-Immunoprecipitations; Communication; Complex; Cytolysis; Cytoplasm; Defect; Diabetes Mellitus; Diffuse; Disease; Disorder; Dyslipidemias; Electron Microscopy; Endoplasmic Reticulum; Endosomes; Energy Intake; Enzymes; Ergastoplasm; Fat Cells; Fats; Fatty Acids, Nonesterified; Fatty Acyl CoA; Fatty Liver; Fatty Tissue; Fatty acid glycerol esters; Free Fatty Acids; GNG3LN protein, human; Gene Deletion; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Golgi; Golgi Apparatus; Golgi Complex; Health; Heart Diseases; Human; Human, General; Insulin Resistance; Life; Ligand Binding Protein; Lipase; Lipid Trafficking; Lipids; Lipocytes; Lipodystrophy; Liver; Liver Steatosis; Long-Chain Acyl CoA; Lysis; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Membrane; Metabolic Diseases; Metabolic Disorder; Mice; Murine; Mus; Muscle; Muscle Tissue; Mutate; Mutation; Nonesterified Fatty Acids; Obesity; Organ failure; Organelles; Pathway interactions; Process; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Receptosomes; Risk; Risk Factors; Role; Site; Stroke; Surface; Syndrome; Testing; Thesaurismosis; Tissues; Triacylglycerol; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triglycerides; Triolean Hydrolase; V-ATPase; V-type ATPase; VESCL; Vacuole; Vascular Accident, Brain; Vesicle; Work; Yeasts; adipose; adiposity; body system, hepatic; brain attack; caloric dietary content; cell imaging; cellular imaging; cerebral vascular accident; corpulence; corpulency; corpulentia; design; designing; diabetes; disease/disorder; experiment; experimental research; experimental study; falls; fatty acid oxidation; gene deletion mutation; gene function; gene product; genome mutation; heart disorder; hepatic steatosis; human BSCL2 protein; human disease; insulin resistant; lipid transport; lipin; lipine; luminal membrane; membrane structure; metabolism disorder; novel; obese; obese people; obese person; obese population; organ system, hepatic; pathway; peroxisome; public health relevance; research study; retrograde transport; seipin; social role; stem; stroke; trafficking; tributyrase; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase; white adipose tissue; yellow adipose tissue",A Simple Cellular Model for Lipodystrophy,,84210,MBPP,Membrane Biology and Protein Processing Study Section,S1,2,31500,
8017207,R01,GM,3,,01/01/2010,12/31/2010,PA-07-070,3R01GM084244-02S1,,NIGMS:69912;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOCHEMISTRY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"HUANG, TONY TUNG;",8953734;,3R01GM084244,01/01/2009,12/31/2013,"APF-1; ATP-Dependent Proteolysis Factor 1; Binding; Binding (Molecular Function); Cancer Susceptibility Pathway; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chromatin; Complex; DNA Damage; DNA Damage Repair; DNA Injury; DNA Interstrand Cross-Link Repair; DNA Repair; Defect; Deubiquitinating Enzyme; Deubiquitination; Enzymes; Equilibrium; Event; Fanconi Anemia; Fanconi Anemia Complementation Group Protein; Fanconi anemia protein; Fanconi dysplasia; Fanconi's Anemia; Gene Family; General Population; General Public; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genome Instability; Genome Stability; Genomic Instability; HMG-20; Hereditary; High Mobility Protein 20; Human; Human, General; Inherited; Intracellular Communication and Signaling; Laboratories; Lead; Libraries; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Molecular; Molecular Interaction; Monoubiquitination; Mutate; Mutation; Oncogenesis; Pancytopenia, Congenital; Panmyelopathy, Fanconi; Pathway interactions; Patients; Pb element; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Primary Erythroid Hypoplasia; Process; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Role; Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Stability, Genomic; Susceptibility; Syndrome; System; System, LOINC Axis 4; Tumor Suppression; Tumor Suppression, Molecular; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Unscheduled DNA Synthesis; balance; balance function; base; biological signal transduction; cancer initiation; congenital aplastic anemia; early onset; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; malignancy; member; mutant; neoplasm/cancer; novel; pathway; public health relevance; response; screening; screenings; social role; tumorigenesis; ubiquination; ubiquitin conjugation",Role of Deubiquitination in Fanconi Anemia Cancer Susceptibility Pathway," The familial genome instability or cancer susceptibility syndrome, Fanconi Anemia (FA), is caused by mutations in 1 of at least 13 FA genes. Biallelic mutations in some of these genes also occur in cancers of non-FA patients, implicating these genes in tumor suppression or genome maintenance among the general population. The results of our studies will help to define the molecular mechanisms of the Fanconi Anemia pathway and how dysregulation of this pathway can lead to oncogenesis.",84244,CSRS,Cellular Signaling and Regulatory Systems Study Section,S1,2,69912,
8007535,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM084279-02S1,,NIGMS:66540;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,ENGINEERING (ALL TYPES),53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"IDEKER, TREY  (contact);KROGAN, NEVAN J;",7040047 (contact);8731876;,3R01GM084279,01/20/2010,12/31/2010,"2PP2A; Address; Affinity Chromatography; Amino Acid Sequence; Animal Model; Animal Models and Related Studies; Architecture; Area; Assay; Bears; Binding; Binding (Molecular Function); Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biology; CHIP assay; California; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Chromatography, Affinity; Commit; Communities; Companions; Complex; Computer Programs; Computer software; DNA Binding; DNA Binding Interaction; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA-Protein Interaction; Data; Databases, Genetic; Databases, Protein; EC 2.7; EC 2.7.2-; EMAP; EMAP-2 protein, human; EMAPL2 protein, human; EML2 protein, human; Endomycetales; Engineering / Architecture; Eukaryota; Eukaryote; Event; Evolution; Exons; Extracellular Signal-Regulated Kinases; Fission Yeast; Follow-Up Studies; Followup Studies; Funding; Gene Deletion; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Data Banks; Genetic Data Bases; Genetic Databanks; Genetic Databases; Genetic Information Databases; Genetic Screening; Genetic analyses; Genetic defect; Genome; Genomics; Goals; Grant; HLA-DR Associated Protein II; Housing; HuEMAP-2 protein, human; I2PP2A; IGAAD; In Vitro; Inhibitor of GZMA-Activated DNase; Institutes; Intervening Sequences; Introns; Kinases; Laboratories; Libraries; MAP kinase; MAPK; Mammalia; Mammals; Mammals, General; Maps; Measures; Method LOINC Axis 6; Methodology; Methods; Mitogen-Activated Protein Kinases; Modeling; Molecular Biology, Protein Sequencing; Molecular Interaction; Mutation; Neighborhoods; PHAPII; Pathway interactions; Peptide Sequence Determination; Phenotype; Phosphatase 2A Inhibitor I2PP2A; Phosphorylation; Phosphotransferases; Physiology; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Databases; Protein Phosphorylation; Protein Sequencing; Protein Structure, Primary; Proteins; Quantitative Genetics; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA Splicing; RNAi; Relative; Relative (related person); Research; Research Resources; Resources; Role; S cerevisiae; S pombe; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Saccharomyces cerevisiae; Saccharomycetales; San Francisco; Schizosaccharomyces pombe; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Sequence-Specific Posttranscriptional Gene Silencing; Set protein; Signal Pathway; Software; Splicing; Subcellular Process; TAF-IBETA; Technology; Template Activating Factor I Beta; Time; Translating; Translatings; Transphosphorylases; Universities; Ursidae; Ursidae Family; Validation; Variant; Variation; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeast, Fission; Yeasts; affinity purification; base; chromatin immunoprecipitation; comparative; comparative genomics; computer program/software; data integration; density; echinoderm MT-associaated protein -like protein 70, human; echinoderm microtubule associated protein like 2 protein, human; eukaryotida; gene deletion mutation; gene product; genetic analysis; genome mutation; genome-wide; human EML2 protein; insight; knockout gene; language translation; model organism; mutant; pathway; protein complex; protein protein interaction; protein sequence; scaffold; scaffolding; social role; tandem mass spectrometry; tool; transcription factor",Comparative Analysis of Genetic and Physical Interaction Networks in Yeasts,,84279,GCAT,"Genomics, Computational Biology and Technology Study Section",S1,2,66540,
8008958,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM084530-06A2S1,,NIGMS:94714;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SANTA CRUZ,UNITED STATES,CHEMISTRY,17,125084723,US,CA,95064,UNIVERSITY OF CALIFORNIA SANTA CRUZ,"LOKEY, R SCOTT;",3092491;,3R01GM084530,01/28/2010,12/31/2010,"Accounting; Affinity; Age; Amides; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibiotics, Antifungal; Antifungal Agents; Antifungal Antibiotics; Antifungal Drug; Assay; Bacteria; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Factors; Biological Function; Biological Process; Cell Membrane Permeability; Cells; Characteristics; Chemical Models; Chemistry, Organic; Collection; Cyclic Peptides; Development; Diffusion; Drug Precursors; Exhibits; Factor, Biologic; Fungicides, Therapeutic; Generations; H element; High Throughput Assay; Hydrogen; Lead; Learning; Libraries; Ligands; Lipid Bilayers; Mammalian Cell; Membrane; Methods; Methylation; Miscellaneous Antibiotic; Models, Chemical; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Natural Products; Nuts; Organic Chemistry; Parents; Pb element; Peptides; Permeability; Phenotype; Pro-Drugs; Prodrugs; Programs (PT); Programs [Publication Type]; Protein Methylation; Relative; Relative (related person); Research; Side; Spinal Column; Spine; Testing; Time; V. cholerae; V.cholerae; Vertebral column; Vibrio cholerae; Vibrio comma; Yeasts; anti-fungal; antifungals; backbone; base; conformation; conformational state; drug development; heavy metal Pb; heavy metal lead; high throughput screening; improved; lipid bilayer membrane; membrane permeability; membrane structure; new approaches; novel approaches; novel strategies; novel strategy; programs; public health relevance; scaffold; scaffolding; small molecule",Synthesis and discovery of biologically active cell-permeable  cyclic peptides," Project narrative  The overall objective of our research program is to understand the structural basis of membrane permeability in small molecules. We propose to use cyclic peptides as molecular scaffolds to study the conformational basis of permeability, and apply what we learn to create a new generation of biochemical probes. We combine computational approaches with synthetic organic chemistry and high-throughput screening to develop a new class of bioactive cyclic peptides inspired by natural products. We expect that new antibiotics and antifungal agents will emerge from this project.",84530,SBCA,Synthetic and Biological Chemistry A Study Section,A2S1,6,94714,
8008956,R01,GM,3,Y,01/28/2010,12/31/2010,PA-07-070,3R01GM084546-12S1,,NIGMS:99995;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PULLMAN,UNITED STATES,CHEMISTRY,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"JONES, JEFFREY P;",7030093;,3R01GM084546,01/28/2010,12/31/2010,"2-dimensional; Absorption; Active Oxygen; Address; Affinity; Apoproteins; Applications Grants; Autoregulation; Benchmarking; Benign; Best Practice Analysis; Binding; Binding (Molecular Function); Cancer Cause; Cancer Etiology; Code; Coding System; Computer Programs; Computer Simulation; Computer software; Computerized Models; Computing Methodologies; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Descriptor; Drug Design; Drug Interactions; Drugs; Electronics; Enzymes; Excretory function; Family; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Goals; Grant; Grant Proposals; Grants, Applications; Heme; Heme Iron; Heme b; Homeostasis; Housing; Intermediary Metabolism; Investigators; Iron; Isotopes; Knowledge; L-Threonine; Life; METBL; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mediating; Medication; Metabolic; Metabolic Processes; Metabolism; Methods; Modeling; Models, Computer; Molecular Interaction; N element; N2 element; Nitrogen; O element; O2 element; Oxygen; Oxygen Radicals; P450; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Pro-Oxidants; Process of absorption; Protoheme; Protoheme IX; Public Domains; Publications; Publishing; Reaction; Reactive Oxygen Species; Relative; Relative (related person); Research; Research Personnel; Researchers; Risk Assessment; Scientific Publication; Series; Simulation, Computer based; Site; Software; Source Code; Specificity; System; System, LOINC Axis 4; Testing; Threonine; Time; Toxic effect; Toxicities; Translating; Translatings; Validation; Work; absorption; abstracting; base; clinical data repository; clinical data warehouse; computational methodology; computational methods; computational modeling; computational models; computational simulation; computational tools; computer based models; computer based prediction; computer methods; computer program/software; computerized modeling; computerized simulation; computerized tools; data repository; design; designing; develop software; developing computer software; drug development; drug metabolism; drug/agent; excretion; ferroheme; in silico; inhibitor; inhibitor/antagonist; language translation; meetings; mutant; new therapeutics; next generation therapeutics; novel therapeutics; open source; oxene; oxidation; pathway; predictive modeling; prevent; preventing; protonation; public health relevance; relational database; software development; therapeutic target; tool; two-dimensional; virtual; virtual simulation; web site",Predicting Rates and Regioselectivity in Cytochrome P450 Mediated Reactions,,84546,ZRG1,Special Emphasis Panel,S1,12,99995,
8007536,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM084547-01A1S1,,NIGMS:123480;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BIRMINGHAM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"THOMPSON, SUNNIE R;",6160640;,3R01GM084547,01/20/2010,12/31/2010,"2,4(1H,3H)-Pyrimidinedione, 5-beta-D-ribofuranosyl-; 5' Untranslated Regions; 5'UTR; API3; Affect; Affinity; After Care; After-Treatment; Aftercare; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; BIRC4; BIRC4 gene; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Biological Models; CDK inhibitor p27; CDKN1B; CDKN1B protein; CDKN4 protein; Cancer Relapse; Cancer Treatment; Cancers; Cell Death; Cell Death, Programmed; Cells; Cellular Expansion; Cellular Growth; Cellular Stress; Chemistry, Biological; Complex; Coupling; Cyclin-Dependent Kinase Inhibitor p27; Defect; Development; Eukaryote; Eukaryotic Cell; Exhibits; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetics-Mutagenesis; Growth; Hereditary Disease; Human; Human, General; Hypoxia; Hypoxic; ILP; IRES; In Vitro; Initiation Factors; Intercistronic Region; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; Kip1 protein; Laboratories; Link; M Phase; M phase (cell cycle); MIHA; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Mitosis; Mitosis Stage; Model System; Modeling; Models, Biologic; Modification; Molecular Biology, Mutagenesis; Molecular Disease; Molecular Interaction; Multiple Myeloma; Murine; Mus; Mutagenesis; Mutation; Myeloma, Plasma-Cell; Nucleotides; Oncogenesis; Oxygen Deficiency; P27KIP1; Patients; Peptide Biosynthesis, Ribosomal; Peptide Initiation Factors; Position; Positioning Attribute; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Pseudouridine; RNA, Messenger; RNA, Viral; Recruitment Activity; Regions, Intergenic; Reporting; Ribosomal Proteins; Ribosomal RNA; Ribosome Entry Site; Ribosomes; Small Nucleolar RNA; Starvation; Structure; System; System, LOINC Axis 4; Tissue Growth; Translating; Translatings; Translation Initiation; Translation Initiation Factor; Translational Initiation Factor; Translations; Tumor Suppressor Proteins; Viral; X-Linked Dyskeratosis Congenita; XIAP; Yang; Yeasts; Zinsser Cole Engman Syndrome; angiogenesis; anticancer therapy; base; c myc; c-myc Genes; cancer cell; cancer therapy; cancer type; cell growth; cricket paralysis virus; cyclin-dependent kinase inhibitor 1B; eukaryotida; gene product; genetic disorder; genome mutation; hereditary disorder; in vivo; innovate; innovation; innovative; interest; language translation; mRNA; mRNA Leader Sequences; malignancy; mutant; myeloma; myelomatosis; necrocytosis; neoplasm/cancer; ontogeny; p27 Kip1 protein; p27 protein; p27(Kip); p27-Kip1; p27Kip1 protein; protein synthesis; public health relevance; rRNA; recruit; snoRNA; tumor suppressor; tumorigenesis; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; viral RNA; virus RNA; yeast genetics",Mechanism of IRES-Mediated Translation Initiation," 7) PROJECT NARRATIVE:  Some viral and cellular mRNAs utilize an alternative mechanism of translation initiation that recruits ribosomes internally to the message using a highly structured internal ribosome entry site (IRES). IRES-mediated translation of cellular mRNAs is involved in regulating cancer, cell death, cell growth, and angiogenesis, as well as translation of viral RNAs. We are using yeast genetics to understand the mechanism of IRES-mediated translation initiation.",84547,MGC,Molecular Genetics C Study Section,A1S1,1,123480,
8007537,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-130,3R01GM084797-02S1,,NIGMS:242672;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MINNEAPOLIS,UNITED STATES,NONE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MANSKY, LOUIS M;",1895895;,3R01GM084797,01/20/2010,12/31/2010,"2(1H)-Pyrimidinone, 4-amino-; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Antiretroviral drug resistance; Cell Line; Cell Lines, Strains; CellLine; Cells; Cytosine; DNA; DNA Recombination; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA recombination (naturally occurring); DNA, Viral; Deamination; Deoxynucleotide-triphosphate[{..}]DNA deoxynucleotidyltransferase (RNA-directed); Deoxyribonucleic Acid; Development; Disease Progression; Drug resistance; Drug resistant viral; EC 2.7.7.49; Evolution; Gene variant; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Recombination; Genetic Variation; Genetic defect; Genetics-Mutagenesis; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Health; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Immune system; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Investigation; Knowledge; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Molecular Biology, Mutagenesis; Mutagenesis; Mutate; Mutation; Mutation Analysis; NNRTI-resistance; Nucleosides; Play; Population; Proteins; Proviruses; RNA Transcriptase; RNA-Dependent DNA Polymerase; RNA-Directed DNA Polymerase; Reagent; Recombination; Recombination, Genetic; Reverse Transcriptase; Revertase; Role; Shapes; System; System, LOINC Axis 4; Testing; Vaccines; Variant; Variation; Variation (Genetics); Viral; Viral Pathogenesis; Virus; Virus-HIV; Viruses, General; allelic variant; anti-retroviral drug resistance; anti-retroviral drug resistant; antiretroviral drug resistant; body system, allergic/immunologic; cultured cell line; drug resistant; drug resistant virus; experiment; experimental research; experimental study; fitness; gene product; genome mutation; human T cell leukemia virus III; human T lymphotropic virus III; improved; novel; organ system, allergic/immunologic; prophylactic; public health relevance; research study; resistance to Drug; resistance to anti-retroviral drug; resistance to antiretroviral drug; resistant to Drug; resistant to anti-retroviral drug; resistant to antiretroviral drug; social role; transition mutation; vaccine development; vector; viral DNA; virus DNA",HIV mutagenesis and evolution,,84797,ZRG1,Special Emphasis Panel,S1,2,242672,
8007539,R01,GM,3,Y,01/22/2010,12/31/2010,PA-07-070,3R01GM085121-02S1,,NIGMS:110140;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SANTA CRUZ,UNITED STATES,BIOCHEMISTRY,17,125084723,US,CA,95064,UNIVERSITY OF CALIFORNIA SANTA CRUZ,"SANFORD, JEREMY ROBERT;",8766683;,3R01GM085121,01/22/2010,12/31/2010,"Address; Affect; Alternate Splicing; Alternative Splicing; Arginine; Arginine, L-Isomer; Assay; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Bioassay; Biochemical; Biochemistry; Bioinformatics; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Chemistry, Biological; Code; Coding System; Combining Site; Complex; Computational Biology; DNA Molecular Biology; DNA Sequence; Data; Elements; Employee Strikes; Exons; Family; Functional RNA; GWAS; Gene Expression; Gene Expression Profile; Gene Products, RNA; Gene Transcription; Genes; Genetic Transcription; Genome, Human; Genomics; Goals; Human; Human Genome; Human, General; In Situ; In Vitro; Indiana; Infrastructure; Interdisciplinary Research; Interdisciplinary Study; Intervening Sequences; Intracellular Communication and Signaling; Introns; L-Arginine; L-Serine; Life; Location; Man (Taxonomy); Man, Modern; Medical center; Method LOINC Axis 6; Methodology; Methods; Molecular Biology; Molecular Interaction; Molecular Weight; Multidisciplinary Collaboration; Multidisciplinary Research; Non-Coding; Non-Coding RNA; Physiologic; Physiological; Post-Transcriptional Control; Post-Transcriptional RNA Modification; Post-Transcriptional RNA Processing; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Pre-mRNA; Protein Binding; Protein Family; Proteins; RNA; RNA Expression; RNA Processing, Post-Transcriptional; RNA Processing, Posttranscriptional; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA-Binding Proteins; RNA-Protein Interaction; RT-PCR; RTPCR; Reaction; Reactive Site; Regulation; Regulatory Element; RegulatoryElement; Research Infrastructure; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Splicing; Strikes; Strikes, Employee; Study, Interdisciplinary; Transcript; Transcription; Transcription, Genetic; Universities; Validation; biological signal transduction; cis acting element; gene expression signature; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human disease; in vivo; mRNA Precursor; novel; premRNA; protein complex; protein expression; reverse transcriptase PCR; statistics/biometry; transcriptome; whole genome association studies; whole genome association study",Genomic analysis of RNA binding protein target specificity,,85121,GCAT,"Genomics, Computational Biology and Technology Study Section",S1,2,110140,
8000246,R01,GM,3,Y,01/14/2010,12/31/2010,PA-07-070,3R01GM085146-01A1S1,,NIGMS:79750;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GUO, WEI ;",6672222;,3R01GM085146,01/14/2010,12/31/2010,"Actin Filaments; Actins; Anthelone U; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Cancers; Causality; Cell Locomotion; Cell Membrane Extensions; Cell Membrane Projections; Cell Membrane Protrusions; Cell Migration; Cell Movement; Cell Surface Extensions; Cell Surface Projections; Cell Surface Protrusions; Cell membrane; Cell surface; Cells; Cellular Migration; Chemotaxis; Complex; Coupled; Cytoplasmic Membrane; Data; Disease; Disorder; EC 2.7; EGF; Electron Microscopy; Embryo Development; Embryogenesis; Embryonic Development; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Etiology; Exocytosis; Fluorescence Microscopy; Generations; Growth Factor Interaction; Human Urinary Gastric Inhibitor; In Vitro; Kinases; Lead; Light; Macromolecular Protein Complexes; Malignant Neoplasms; Malignant Tumor; Mediating; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Microfilaments; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular; Molecular Interaction; Monitor; Motility; Motility, Cellular; Multiprotein Complexes; Mutate; Myofilaments; Neoplasm Metastasis; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Organism-Level Process; Organismal Process; Pb element; Phosphorylation; Phosphotransferases; Photoradiation; Physiologic Processes; Physiological Processes; Plasma Membrane; Play; Protein Phosphorylation; Regulation; Role; Secondary Neoplasm; Secondary Tumor; Testing; Transphosphorylases; Tumor Cell Migration; Urogastrone; VESCL; Vesicle; Wound Healing; Wound Repair; base; beta-Urogastrone; cancer metastasis; cell motility; directional cell; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; heavy metal Pb; heavy metal lead; malignancy; membrane activity; membrane structure; migration; neoplasm/cancer; nervous system disorder; neurological disease; neuron development; plasmalemma; polarized cell; polymerization; protein complex; public health relevance; reconstitute; reconstitution; response; social role; time use; tissue repair; tomography; tumor",The role of the exocyst in cell migration," Project Narrative:  Directional cell migration is fundamental to many physiological processes such as chemotaxis, embryogenesis, and neuronal development. Studying the molecular basis of cell migration will help us understand these physiological processes and shed light on the etiologies of diseases such as neurological disorders and cancer.",85146,CSF,Cell Structure and Function Study Section,A1S1,1,79750,
8007542,R01,GM,3,Y,01/20/2010,12/31/2010,PA-07-070,3R01GM085282-02S1,,NIGMS:127823;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STRATFORD,UNITED STATES,BIOCHEMISTRY,01,140757589,US,NJ,08084,UNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED,"ELLIS, RONALD E;",7068481;,3R01GM085282,01/20/2010,12/31/2010,"ACT2; AT744.1; Act-2; Address; Aging; Animal Model; Animal Models and Related Studies; Animals; Aves; Avian; Basic Research; Basic Science; Bears; Binding; Binding (Molecular Function); Biomedical Research; Birds; C elegans; C.elegans; CCL4; CCL4 gene; Caenorhabditis elegans; Cell Death; Chromosome Mapping; Cloning; Cloning, Molecular; Complex; Data; Development; Disease; Disorder; Employee Strikes; Enhancers; Evolution; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; Female; Fogs; Funding; Future; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; GeneHomolog; Genes; Genes, Regulator; Genetic; Genetic Screening; Genetics, Gene Mapping; Genome; Habits; Hermaphroditism; Homolog; Homologous Gene; Homologue; Human; Human, General; Influentials; Intersexuality; LAG1; Learning; Linkage Mapping; MIP-1-beta; MIP1B; Man (Taxonomy); Man, Modern; Medical; Methods and Techniques; Methods, Other; Micro RNA; MicroRNAs; Mind; Molecular Analysis; Molecular Cloning; Molecular Genetic; Molecular Genetics; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Selections; Nematoda; Nematodes; Partner in relationship; Pathway interactions; Phylogeny; Physicians; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Binding; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulator Genes; Regulatory Pathway; Reproductive Biology; Research; Role; SCF Ubiquitin Ligase; SCYA4; SKP Cullin F-Box Protein Ligases; SNP Map; Scientist; Selections, Natural; Senescence; Sequence-Specific Posttranscriptional Gene Silencing; Single Nucleotide Polymorphism Map; Sperm; Spermatogenesis; Spermatozoa; Strikes; Strikes, Employee; Structure; Study models; System; System, LOINC Axis 4; Techniques; Textbooks; Time; Transcriptional Regulatory Elements; Transgenic Animals; United States National Institutes of Health; Ursidae; Ursidae Family; Wing; Work; disease/disorder; experiment; experimental research; experimental study; fighting; functional genomics; gene function; gene product; genetic mapping; genome sequencing; interest; mate; member; miRNA; model organism; mutant; necrocytosis; novel; pathway; regulatory gene; research study; roundworm; senescent; sex determination; social role; sperm cell; theories; tool; trait; trans acting element; zoosperm",Evolution of Developmental Regulatory Pathways,,85282,GVE,Genetic Variation and Evolution Study Section,S1,2,127823,
8007543,R01,GM,3,Y,01/20/2010,12/31/2010,GM-08-002,3R01GM085576-02S1,,NIGMS:138614;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"HARIHARAN, ISWAR K;",1886475;,3R01GM085576,01/20/2010,12/31/2010,"21+ years old; Adult; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Apoptosis; Apoptosis Pathway; Body Tissues; Brachydanio rerio; C elegans; C.elegans; Caenorhabditis elegans; Cardiac infarction; Cell Cycle Control; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical Management; Complex; Crossmatching, Tissue; Danio rerio; Degenerative Disorder; Development; Disease; Disorder; Drosophila; Drosophila genus; Embryo Development; Embryogenesis; Embryonic Development; Fruit Fly, Drosophila; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Growth; Histocompatibility Testing; Human, Adult; In Situ; Injury; Medical; Mutation; Myocardial Infarct; Myocardial Infarction; Natural regeneration; Newts; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Patients; Regeneration; Staging; Stroke; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Time; Tissue Crossmatchings; Tissue Growth; Tissue Typing; Tissues; Vascular Accident, Brain; Wound Healing; Wound Repair; Yeasts; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); brain attack; cardiac infarct; cell killing; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; degenerative condition; degenerative disease; disease/disorder; fruit fly; genome mutation; heart attack; heart infarct; heart infarction; histocompatibility typing; imaginal disc; improved; model organism; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; regenerate; regenerate new tissue; regenerating damaged tissue; regenerative; stroke; surgery; tissue regeneration; tissue repair; tool",Identifying novel strategies to promote tissue regeneration,"This project is aimed at finding ways to get damaged tissue to be replaced by normal and functional tissue (regeneration). This would be important in the treatment of patients who have had heart attacks, strokes or degenerative diseases.",85576,ZGM1,Special Emphasis Panel,S1,2,138614,
8008957,R01,GM,3,Y,01/28/2010,12/31/2010,GM-08-002,3R01GM085586-02S1,,NIGMS:75000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"KROGSGAARD, MICHELLE ;",8626665;,3R01GM085586,01/28/2010,12/31/2010,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antigens; Assay; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biophysics; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Communities; Complex; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasmic Domain; Cytoplasmic Tail; Diabetes Mellitus; Energy Transfer; Environment; Event; Fluorescence; HIV; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immune response; Intracellular Communication and Signaling; Invaded; Knowledge; LAV-HTLV-III; Ligand Binding; Ligands; Lymphadenopathy-Associated Virus; MHC Receptor; MS (Multiple Sclerosis); Major Histocompatibility Complex Receptor; Malignant Neoplasms; Malignant Tumor; Mediating; Membrane; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Multiple Sclerosis; Nuclear Magnetic Resonance; OKT3 antigen; Outcome; Patients; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Play; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, Antigen, T-Cell; Resolution; Role; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Structure; Subcellular Process; T-Cell Activation; T-Cell Receptor; T-Cell Receptor Interaction; T-Cells; T-Lymphocyte; T3 Antigens; T3 Complex; T3 molecule; TCR Activation; TCR Interaction; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Translating; Translatings; Virus-HIV; X Ray Crystallographies; X-Ray Crystallography; autoimmune disorder; biological signal transduction; conformation; conformational state; design; designing; diabetes; host response; immunogen; immunoresponse; insight; insular sclerosis; interest; language translation; malignancy; membrane structure; neoplasm/cancer; novel; pMHC; pathogen; polypeptide; protein function; protein protein interaction; protein structure; receptor; receptor-mediated signaling; self recognition (immune); social role; therapeutic vaccine; thymus derived lymphocyte",Visualizing ligand-induced signal propagation in the TCR-signaling complex,Proposal narrative We expect that our studies will provide insight into the molecular mechanism of how ligand-induced conformational changes in the T cell receptor influence T-cell activation outcomes with a sensitivity and resolution that has not been possible before. This information will prove useful in both understanding how receptor-mediated signaling is initiated and from a therapeutic point of view to modulate signaling through the T cell receptor pharmacologically to either increase the sensitivity of T-cells in patients with cancer or HIV or decrease the sensitivity in patients with autoimmune diseases (multiple sclerosis or diabetes).,85586,ZGM1,Special Emphasis Panel,S1,2,75000,
8007548,R01,GM,3,Y,01/20/2010,12/31/2010,GM-08-001,3R01GM085659-02S1,,NIGMS:174290;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"CALIFANO, ANDREA ;SANNA, PIETRO P (contact);",1878222 (contact);7831421;,3R01GM085659,01/20/2010,12/31/2010,"21+ years old; AIDS/HIV; AIDS/HIV problem; Adult; Alcohol dependence; Algorithms; Animal Model; Animal Models and Related Studies; Bears; Behavioral; Bio-Informatics; Biochemical; Bioinformatics; Brain region; Breeding; Cancers; Candidate Disease Gene; Candidate Gene; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Chronic Disease; Chronic Illness; Clinical; Common Rat Strains; Complex; Data; Data Set; Dataset; Development; Diagnostic; Direct Costs; Drugs; Electromagnetic, Laser; Elements; Engineering; Engineerings; Environment; Ethanol dependence; Foundations; Funding; Future; Gene Expression Profile; Genes; Genes, Regulator; Genetic; Genomics; HIV/AIDS; HIV/AIDS problem; Head; Health; History; Homogeneously Staining Region; Human; Human, Adult; Human, General; Individual; Individual Differences; Investigation; Lasers; Life; Life Experience; Life Style; Lifestyle; Literature; Malignant Neoplasms; Malignant Tumor; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Medication; Modeling; Molecular; Molecular Neurobiology; Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurobiology, Molecular; Neurocyte; Neurons; Organ System, Cardiovascular; Organism; Pathway interactions; Personal Satisfaction; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physical environment; Predisposition; Prevention; Process; Radiation, Laser; Rat; Rattus; Recording of previous events; Regulation; Regulator Genes; Research; Research Institute; Role; Stimulus; Stress; Stressful Event; Substance abuse problem; Sultan; Susceptibility; System; System, LOINC Axis 4; Systems Biology; Testing; Transcriptional Regulatory Elements; Universities; Ursidae; Ursidae Family; Vascular, Heart; abuse of substances; adult human (21+); alcohol addiction; alcohol dependency; alcohol-dependent; base; biological adaptation to stress; chronic disease/disorder; chronic disorder; circulatory system; coping; design; designing; drug/agent; environment effect on gene; ethanol addiction; ethanol dependency; ethanol-dependent; experience; gene environment interaction; gene expression signature; hsr; living system; malignancy; model organism; neoplasm/cancer; neurobiological; neuronal; new therapeutics; next generation therapeutics; novel therapeutics; pathway; psychological distress; reaction; crisis; reconstruction; regulatory gene; response; scale up; social; social role; stress response; stress; reaction; stressor; substance abuse; trans acting element; transcriptome; well-being",Collaborative study on the systems biology of vulnerability to stress,,85659,ZGM1,Special Emphasis Panel,S1,2,174290,
8000255,R01,GM,3,Y,01/14/2010,12/31/2010,PA-07-070,3R01GM085754-01A1S1,,NIGMS:105330;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,ENGINEERING (ALL TYPES),09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"HEALY, KEVIN E;",1895653;,3R01GM085754,01/14/2010,12/31/2010,"Address; Adherent Culture; Adhesion Plaques; Adhesions; Animals; Area; Behavior Control; Behavioral Manipulation; Biological; Blood (Leukemia); Body Tissues; Cardiac Failure Congestive; Cell Adhesion; Cell Body; Cell Communication and Signaling; Cell Culture Techniques; Cell Fate Control; Cell Fate Regulation; Cell Shape; Cell Signaling; Cell Survival; Cell Viability; Cell-Matrix Adherens Junctions; Cells; Cellular Adhesion; Clinical; Collection; Conditioned Culture Media; Conditioned Medium; Congestive Heart Failure; Culture Media; Culture Media, Conditioned; Development; Diabetes Mellitus; Disadvantaged; Disease; Disorder; Drugs; Embryo; Embryonic; Engineering; Engineerings; Environment; Exhibits; Extracellular Matrix Proteins; Extracellular Matrix, Integrins; Focal Adhesions; Focal Contacts; Generalized Growth; Growth; Heart Decompensation; Heart Failure, Congestive; Human; Human, General; Idiopathic Parkinson Disease; In Situ; Integrins; Intracellular Communication and Signaling; Leukemias, General; Lewy Body Parkinson Disease; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Methods; Mice; Modeling; Monolayer culture; Morphology; Mother Cells; Murine; Mus; Myelopathy, Traumatic; Nuclear; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Peptide Biosynthesis, Ribosomal; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Primary Parkinsonism; Production; Progenitor Cells; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Protocol; Protocols documentation; Regenerative Medicine; Reproducibility; Risk; Screening procedure; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stem cells; Surface; System; System, LOINC Axis 4; Technology; Testing; Tissue Engineering; Tissue Growth; Tissues; Transmission; Treatment Efficacy; Zoonoses; base; behavioral control; biological signal transduction; cell body (neuron); cell type; chemotherapy; density; diabetes; disease/disorder; drug/agent; engineered tissue; growth media; hESC; human ES cell; human ES cell lines; human ESC; human embryonic stem cell; human embryonic stem cell line; large scale production; leukemia; nano pattern; nanopattern; neural cell body; neuronal cell body; novel; ontogeny; pathogen; physical state; protein synthesis; public health relevance; screening; screenings; self-renewal; soma; stem; stem cell differentiation; stem cell population; therapeutic efficacy; therapeutically effective; transmission process",Nanopatterned Surfaces to Control Cell Fate," Project Narrative: This application will focus specifically on engineering a tunable and well-defined environment presenting hES cells with a completely synthetic cell culture surface and chemically-defined media to promote self-renewal. The result will be a synthetic microenvironment that can both serve as a regenerative medicine technology platform for large scale hES cell expansion, as well as provide a novel and highly modular system for dissecting basic signaling mechanisms underlying hES cell self-renewal.",85754,ZRG1,Special Emphasis Panel,A1S1,1,105330,
8013758,R01,GM,3,,08/01/2009,05/31/2010,PA-07-070,3R01GM086495-01A1S1,,NIGMS:10008;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ALBUQUERQUE,UNITED STATES,BIOCHEMISTRY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"PARRA, KARLETT J;",9338420;,3R01GM086495,08/01/2009,05/31/2014,"Abnormal Assessment of Metabolism; Acetyl CoA; Acetyl Coenzyme A; Acid-Base Balance; Acid-Base Equilibrium; Address; African American; Afro American; Afroamerican; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; Aldehyde-Lyases; Aldolases; American Indian; American Indians; Bacterial Toxins; Binding; Binding (Molecular Function); Biochemical; Biological Models; Black Populations; Black or African American; C element; Cancers; Carbon; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chronic Kidney Failure; Chronic Renal Disease; Citrates; Coenzyme A, S-(hydrogen propanedioate); Coenzyme A, S-acetate; Complement; Complement Proteins; Complex; Complexes, Macromolecular; Coupled; Couples; Cytoplasmic Membrane; D-Glucose; Dark Cell; Defect; Development; Dextrose; Diabetes Mellitus; Disease; Disorder; Dysfunction; Elements; Endosomes; Energy Expenditure; Energy Metabolism; Enzymes; Ethnic group; Fats; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty acid glycerol esters; Fructose; Functional disorder; Genetic; Glucose; Glycolysis; Goals; H(+) Pump; H+ element; Hispanic Populations; Hispanics; Hispanics or Latinos; Hydrogen Ions; In Vitro; Indians, American; Insulin Resistance; Intercalated Cell; Intermediary Metabolism; Intracellular Communication and Signaling; Kidney; Kidney Diseases; Kidney Failure, Chronic; Knowledge; Latino Population; Levulose; Link; Lysosomes; METBL; Macromolecular Complexes; Macromolecular Structure; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malonyl CoA; Malonyl Coenzyme A; Measures; Membrane; Membrane of the Lysosome; Metabolic; Metabolic Control; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Molecular Structure; Native Alaskan; Nephrons; Nephropathy; Nutrient; Obesity; Organism; Pathway interactions; Physiology; Physiopathology; Plasma Membrane; Process Measure; Proteins; Proton Pump; Protons; Public Health; Pump; QOL; Quality of life; Receptosomes; Regulation; Renal Cell; Renal Disease; Renal Failure, Chronic; Research; Risk Factors; S cerevisiae; Saccharomyces cerevisiae; Signal Transduction; Signal Transduction Systems; Signaling; Sorting - Cell Movement; Source; Spanish Origin; Structure; System; System, LOINC Axis 4; Testing; Thesaurismosis; Urinary System, Kidney; Uriniferous Tube; V-ATPase; V-type ATPase; Vacuole; Virus; Viruses, General; Warburg Effect; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; YeastModel; Yeasts; adiposity; biological signal transduction; black American; cancer cell; chronic kidney disease; corpulence; corpulency; corpulentia; diabetes; disease/disorder; extracellular; fat metabolism; fatty acid metabolism; fatty acid oxidation; gene product; hispanic community; in vivo; insight; insulin resistant; interest; kidney cell; kidney disorder; lipid metabolism; living system; lysosome membrane; malignancy; membrane structure; metabolic abnormality assessment; metabolism disorder; mutant; neoplasm/cancer; novel; obese; obese people; obese person; obese population; oxidation; pH Homeostasis; pathophysiology; pathway; plasmalemma; public health medicine (field); public health relevance; racial and ethnic; racial/ethnic; reconstitute; reconstitution; renal; renal disorder; response; sorting; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION," Diabetes is a major risk factor for the development and progression of chronic kidney disease (CKD). Diabetes and CKD are important public health problems; both are serious conditions associated with decreased quality of life and have disproportionate impact on certain racial and ethnic groups, especially African Americans, American Indians or Alaska Natives, and Hispanics. This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats.",86495,ZRG1,Special Emphasis Panel,A1S1,1,10008,
8000295,R01,GM,3,Y,01/14/2010,12/31/2010,PA-07-070,3R01GM086862-16A1S1,,NIGMS:88107;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOULDER,UNITED STATES,CHEMISTRY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"PARDI, ARTHUR ;",1868179;,3R01GM086862,01/14/2010,12/31/2010,"37-kDa RBP; 4-dimensional; AZAMP; AZU; AZU1; AZU1 Protein; Address; Affinity; Age; Age related macular degeneration; Aged 65 and Over; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiogenic Proteins; Angiostatic Agents; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Antigenic Determinants; Area; Arts; Assay; Azurocidin; Azurocidin 1; Azurocidin 1 (Cationic Antimicrobial Protein 37); Bacteriophage Pf1; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Blindness; CAP 37; CAP37; Cationic Antimicrobial Protein, 37kd; Cationic Antimicrobial Protein-37; Cell Surface Receptors; Chemicals; Complement; Complement Proteins; Complex; Data; Deuterium; Development; Diagnostic; Drugs; Elderly; Elderly, over 65; Epitopes; FDA approved; Family; Four-dimensional; Fourier Transform; Functional RNA; Gene Probes, RNA; Gene Products, RNA; Goals; H2 isotope; HBP; Heparin Binding; Heparin Binding Protein; Heteronuclear NMR; Heteronuclear Nuclear Magnetic Resonance; Hot Spot; Hot Spots (Area of Increased Mortality); Human; Human, General; Humazur; In Vitro; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Kinetic; Kinetics; Lead; Ligand Binding Protein; Maculopathy, Age-Related; Man (Taxonomy); Man, Modern; Maps; Measurement; Medication; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Molecular Probes; NAZC; NMR Spectroscopy; NMR, Heteronuclear; Neovascularization Inhibitors; Neutrophil Azurocidin; Non-Coding; Non-Coding RNA; Nuclear Magnetic Resonance; Nucleic Acids; Pb element; Phage Pf1; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Play; Process; Property; Property, LOINC Axis 2; Proteins; Pseudomonas phage Pf1; RNA; RNA Probes; RNA, Non-Polyadenylated; RNA-Protein Interaction; Receptors, Cell Surface; Regulatory Protein; Residual; Residual state; Resolution; Ribonucleic Acid; Role; Series; Site; Solutions; Specificity; Spectroscopy, NMR; Structure; Surface; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Thermodynamic; Thermodynamics; Time; Transform, Fourier; VEGF(165); VEGF(165) protein, human; VEGF165; VEGF165 protein, human; VEGFs; Variant; Variation; Vascular Endothelial Growth Factors; Vegf; advanced age; angiogenesis; antiangiogenic; aptamer; base; cationic antimicrobial protein CAP 37; cellular targeting; design; designing; drug/agent; elders; experiment; experimental research; experimental study; gene product; genetic regulatory protein; geriatric; heavy metal Pb; heavy metal lead; heparin-binding protein 37-kDa; improved; inhibitor; inhibitor/antagonist; late life; later life; mutant; novel; nuclear magnetic resonance spectroscopy; older adult; older person; protein complex; rapid method; rapid technique; regulatory gene product; research study; senile macular disease; senior citizen; social role",Structure and Dynamics of RNA and Protein-RNA Complexes," Project Narrative This proposal will study the recently FDA-approved RNA aptamer drug, Macugen, interacting with its cellular target, vascular endothelial growth factor. Macugen is used to treat the wet-form of Age- Related Macular Degeneration, the leading cause of blindness in people over age 50.",86862,MSFB,Macromolecular Structure and Function B Study Section,A1S1,16,88107,
8000298,R01,GM,3,Y,01/29/2010,12/31/2010,PAR-07-234,3R01GM087977-01S1,,NIGMS:297297;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"SIMON, SANFORD M;",1908323;,3R01GM087977,01/29/2010,12/31/2010,"Affect; Assay; Behavior; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Models; Biology; Blood erythrocyte; Blood normocyte; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chemistry; Cultured Cells; Cytosol; Defect; Disease; Disorder; Erythrocytes; Erythrocytic; Event; Exposure to; H(+) Pump; Hemagglutinin; Image; Individual; Influenza HA; Influenza Hemagglutinin; Intervening Protein Sequence; Label; Left; Life; Marrow erythrocyte; Methods; Methods and Techniques; Methods, Other; Microinjections; Model System; Models, Biologic; Modification; Molecular; Molecular Machines; Motor; NPC; Nuclear Pore; Nuclear Pore Complex; Nucleus; Optics; Organ; Organelles; Pathology; Pathway interactions; Patients; Peptides; Physiologic; Physiological; Physiology; Process; Protein Introns; Protein Splicing; Proteins; Proton Pump; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reticuloendothelial System, Erythrocytes; Science of Chemistry; Subcellular Process; Surface; System; System, LOINC Axis 4; Techniques; Technology; Temperature; Testing; Variant; Variation; Viral Fusion Proteins; Virus; Viruses, General; Whole Organism; Work; biological systems; blood corpuscles; cell biology; disease/disorder; fusion protein (viral coat); gene product; imaging; insight; intein; interest; macromolecule; new technology; novel; optic imaging; optical imaging; pathway; protein expression; public health relevance; single molecule; stable cell line",Selective fluorescent labeling of proteins in living cells," Optical imaging has contributed very significant advances to our understanding of biology in the last few years. This is the consequence of a number of advantages of imaging: Imaging allows us to study biological systems that are still alive; Imaging allows us to study individual molecules, individual cells rather than the average behavior; Imaging allows us to study many different size scales from single molecules to whole individuals. Often a defect that occurs at the level of a single molecule represents itself as pathology at the level of the whole organism. Imaging allows us to follow the disease from the single molecule, to the molecular machine, to the whole cell, to the whole organ, to the individual patient. A major limitation of optical imaging has been the capability to get probes into cells to specifically and selectively label individual molecules. This proposal will contribute to our ability to study individual molecular events in the cell by giving us new methods of putting our probes into cells, without disturbing the cells and new methods of labeling cellular components with minimal, often no, effect on the cell.",87977,ZRG1,Special Emphasis Panel,S1,1,297297,
8017667,R01,HL,3,,02/01/2010,01/31/2011,,3R01HL080387-05S1,,NHLBI:61805;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"GENCO, CAROLINE A;",1878740;,3R01HL080387,02/01/2006,01/31/2011,"A Mouse; APOE [{C0003595}]; Acceleration; Accounting; Acute; Animal Model; Animal Models and Related Studies; Aorta; Apo-E; ApoE; Apolipoprotein E; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Automobile Driving; Bacteria; Bacteroides gingivalis; Breeding; C. pneumoniae; C. pylori; C.pneumoniae; Campylobacter pylori; Cardiovascular Diseases; Causality; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chlamydia pneumoniae; Chlamydophila pneumoniae; Chronic; Clinical; Data; Development; Diet; Drivings, Automobile; Endothelial Cells; Etiology; Experimental Models; Experimental Models, Other; Fats; Fatty acid glycerol esters; Genetic; H. pylori; H. pylory; H.pylori; Helicobacter pylori; Human; Human, General; INFLM; Immune; Immune Markers; Immunologic Markers; Infection; Infectious Agent; Inflammation; Inflammatory Response; Intracellular Communication and Signaling; Investigators; Knockout Mice; Lesion; Life; Ligands; Link; Lipids; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Mice; Mice, Knock-out; Mice, Knockout; Microbe; Microorganisms, General; Modeling; Models, Experimental; Molecular; Murine; Mus; Nucleus; Null Mouse; Oral; P. gingivalis; P.gingivalis; Pathogenesis; Pathway interactions; Pattern recognition receptor; Phase; Play; Porphyromonas gingivalis; Programs (PT); Programs [Publication Type]; Reporting; Research Personnel; Researchers; Risk Factors; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smoking; Streaks, Arterial Fatty; TIL4; TLR protein; TLR2; TLR2 gene; TLR2 receptor; TLR4; TLR4 gene; TLR4 receptor; TOLL; Toll-4 receptor; Toll-Like Receptor 2; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin 1 Receptor-Like Protein 4; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; biological signal transduction; cardiovascular disorder; diet and exercise; disease causation; disease etiology; disease/disorder etiology; disorder etiology; driving; feeding; fimbria; hToll; improved; infection mouth; infectious organism; inflammatory marker; macrophage; microbial antigen; microorganism; microorganism antigen; model organism; mouse model; oral infection; oral infectious; pathogen; pathway; programs; receptor expression; response; social role; toll-like receptor 4; vulnerable plaque",Invasive Bacteria Accelerate Atherosclerosis through TLRs,,80387,HIBP,Host Interactions with Bacterial Pathogens Study Section,S1,5,61805,
8016789,R01,HL,3,,02/01/2010,12/31/2010,,3R01HL087033-04S1,,NHLBI:12136;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,MISCELLANEOUS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"FAIRWEATHER, DELISA ;",6166319;,3R01HL087033,01/01/2007,12/31/2011,"APC; Acute; Acute Myocarditis; Adaptor Protein; Adaptor Signaling Protein; Address; Adjuvant; Antigen-Presenting Cells; Ascaridil; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; B7-1; BALB/c; BB1; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basophilic Histiocyte; Basophils, Tissue; Body Tissues; CD28LG; CD28LG1; CD80; CD80 gene; Cardiac Diseases; Cardiac Disorders; Cardiomyopathy, Dilated; Cardiovascular Diseases; Cause of Death; Cell Communication and Signaling; Cell Count; Cell Number; Cell Signaling; Cells; Cessation of life; Chronic; Congestive Cardiomyopathy; Coxsackie Viruses; Coxsackievirus; Cytokine Signal Transduction; Cytokine Signaling; Cytokines, Chemotactic; DIF; Death; Decaris; Development; Differentiation Factor, B-Cell; Dilated Cardiomyopathy; Disease; Disorder; EC 2.7; Edodekin Alfa; Equilibrium; Ergamisol; Ergamisole; Female; Figs; Figs - dietary; Genes; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Goals; HPGF; Heart; Heart Diseases; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; Hour; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFN-gamma-Inducing Factor; IFNB2; IGIF; IL-1; IL-1 Gamma; IL-12; IL-18; IL-1g; IL-6; IL1; IL12; IL18 Protein; IL1F4; IL6 Protein; INFLM; IRF3; IRF3 gene; Immune; Immune Globulins; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunization; Immunoglobulins; Immunoglobulins / Antibodies; Immunol; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Inbred BALB C Mice; Incidence; Infection; Inflammation; Inflammatory; Inflammatory Response; Intercrines; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-1 Gamma; Interleukin-12; Interleukin-18; Interleukin-18 Precursor; Interleukin-6; Interleukins; Intracellular Communication and Signaling; Investigators; Ketrax; Kinases; Knowledge; LAB7; Ligands; Link; Lymphocyte-Stimulating Hormone; MGC12320; MGI-2; MHC Class II; MHC Class II Genes; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Inbred BALB C; Modeling; Monocytes / Macrophages / APC; Mouse, BALB C; Mucins; Mucus Glycoprotein; Murine; Mus; Myeloid Differentiation-Inducing Protein; Myocarditis; NKSF; Natural Immunity; Natural Killer Cell Stimulatory Factor; Paper; Pathway interactions; Patients; Phosphotransferases; Plasmacytoma Growth Factor; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Receptor Protein; Receptor Signaling; Recruitment Activity; Regulation; Regulatory T-Lymphocyte; Research; Research Personnel; Researchers; Role; SIS cytokines; Sensitization, Immunologic; Sensitization, Immunological; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solaskil; T Helper Factor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; TIL4; TLR protein; TLR2; TLR2 gene; TLR3; TLR3 gene; TLR4; TLR4 gene; TLR4 receptor; TLR7; TLR7 gene; TNF; TNF A; TNF gene; TNFSF2; TOLL; Thymus-Dependent Lymphocytes; Tissues; Toll-4 receptor; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Tramisol; Transphosphorylases; Trimisol; Tumor Necrosis Factor Gene; Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; Work; accessory cell; balance; balance function; biological signal transduction; cardiovascular disorder; chemoattractant cytokine; chemokine; cytokine; disease/disorder; experiment; experimental research; experimental study; hToll; heart disorder; host response; immunoresponse; interferon beta 2; lymphocyte activating factor; macrophage; male; mast cell; mastocyte; men; men's; mouse model; novel; pathway; prevent; preventing; programs; protein activation; public health medicine (field); receptor; recruit; research study; self recognition (immune); social role; thymus derived lymphocyte; toll-like receptor 4; transcription factor; unspecified interleukin; viral infection; virus infection",Regulating heart disease: the adjuvant effect of viral infection.,,87033,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,S1,4,12136,
8016845,R01,HL,3,,02/01/2010,04/30/2010,PAR-07-352,3R01HL096972-01S1,,NHLBI:12998;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,TROY,UNITED STATES,CHEMISTRY,21,002430742,US,NY,121803590,RENSSELAER POLYTECHNIC INSTITUTE,"DORDICK, JONATHAN S.;LINHARDT, ROBERT J (contact);",1870962 (contact);1887194;,3R01HL096972,08/01/2009,04/30/2014,"2-Amino-2-Deoxyglucose; Acetates; American; Animal Sources; Animal Testing; Animals; Anions; Antithrombin 2; Antithrombin II; Antithrombin III; Area Under Curve; Bioassay, in vitro; Biochemical; Bioequivalence; Biomedical Engineering; Blood Coagulation Factor III; Bovine Spongiform Encephalopathy; Businesses; CD142 Antigens; Callicrein; Capillary Electrophoresis; Cessation of life; Chemicals; China; Chinese Hamster; Chondroitin Sulfates; Chondroitin, hydrogen sulfate; Chromatography, Exclusion; Chromatography, Gel; Chromatography, Gel Permeation; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinical; Clinical Data; Clinical Equivalency; Coagulation Factor III; Coagulin; Complement; Complement Proteins; D-Glucose, 2-amino-2-deoxy-; DNA Synthesis Factor; Deacetylase; Death; Development; Drug Kinetics; Drugs; Drugs, Nonproprietary; EC 2.8.2; EC 3.4.21.7; ECGF; ESI Mass Spectrometry; Electromagnetic, Laser; Electrophoresis, Capillary; Electrophoresis, Polyacrylamide Gel; Encephalitis, Bovine Spongiform; Encephalopathy, Bovine Spongiform; Endothelial Cell Growth Factor; Engineering; Engineerings; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; European Community; European Union; F Factor; F Plasmids; FDA; FGF; Factor III; Factor Xa Inhibitor; Family suidae; Fermentation; Fertility Factor, Bacterial; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Fitzgerald Factor; Fletcher Factor; Fluorescence; Food and Drug Administration; Food and Drug Administration (U.S.); Fractionation, Capillary Electrophoresis; Fractionation, Polyacrylamide Gel; Future; Gel Chromatography; Gel Filtration; Gel Filtration Chromatography; Generic Drugs; Generic Equivalency; Genital System, Female, Ovary; Glomerular Procoagulant Activity; Glucosamine; Glucuronic Acids; Glycosaminoglycans; HBGF; HMWK; HPLC; Hamster, Chinese; Head; Health; Heparin; Heparin Co-Factor I; Heparin Co-Factor II; Heparin Co-Factor One; Heparin Cofactor I; Heparin Cofactor II; Heparin Cofactor One; Heparin, Low-Molecular-Weight; Heparinic Acid; High Pressure Liquid Chromatography; High-Molecular-Weight Kininogen; Human; Human, General; Iduronic Acid; Inorganic Sulfates; Institutes; Institution; Intestinal; Intestines; Intravenous; Ions; Kallidinogenase; Kalliginogenase; Kallikreinogen; Kallikreins; Kilogram; Kinin-Forming Enzyme; Kininogen, High-Molecular-Weight; Kininogenase; LMWH; Laboratories; Lasers; Letters; Link; Liquid Chromatography; Low-Molecular-Weight Heparin; Mad Cow Disease; Mainland China; Man (Taxonomy); Man, Modern; Medication; Method LOINC Axis 6; Methodology; Methods; Molecular Weight; Mucopolysaccharides; North Carolina; Ovary; Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacies; Pharmacodynamics; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Pharmacopoeias; Pharmacy facility; Phase; Pigs; Plasma Prokallikrein; Plasminogen; Polyacrylamide Gel Electrophoresis; Postdoc; Postdoctoral Fellow; Prekallikrein; Principal Investigator; Process; Production; Profibrinolysin; Protein C; Protein-Carbohydrate Interaction; Prothrombin Time; Prothrombin time assay; Prothrombinase; R01 Mechanism; R01 Program; RPG; Radiation, Laser; Reptilase Time; Research; Research Associate; Research Grants; Research Institute; Research Project Grants; Research Projects; Research Projects, R-Series; Resistance Transfer Factor; Safety; Sex Factor F; Sex Factor, Bacterial; Spectrometry, Mass, Electrospray Ionization; Structure; Suidae; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Surface Plasmon Resonance; Swine; Therapeutic; Therapeutic Equivalency; Thrombelastography; Thrombin Time; Thrombin Time Assay; Thromboelastography; Thromboplastin; Time; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Translational Research; Translational Research Enterprise; Translational Science; UDP; USFDA; United States; United States Food and Drug Administration; Universities; Unspecified or Sulfate Ion Sulfates; Uridine 5'-(trihydrogen diphosphate); Uridine Diphosphate; Uridine Pyrophosphate; Urothromboplastin; Variant; Variation; Vascular Endothelial Cell; Weight; animal tissue; bioengineering; bioengineering/biomedical engineering; bioprocess; bowel; college; cost; cost effective; drug bioequivalence; drug bioequivalent; drug development; drug discovery; drug/agent; epimerase; experience; fertility factor; generic; improved; in vitro Bioassay; in vivo; interest; ionization; kininogenin; maltose-binding protein; novel; porcine; post-doc; post-doctoral; pre-clinical; preclinical; prevent; preventing; professor; public health relevance; response; scale up; sex factor; subcutaneous; suid; sulfate; sulfotransferase; translation research enterprise; ultraviolet",Development of a Bioengineered Heparin from a Non-Animal Source,  Project Narrative The proposed effort impacts human health by developing a process to prepare a bioengineered heparin that is chemically and biologically equivalent to pharmaceutical heparin currently prepared from pig intestine. This process will improve the safety and uniformity of heparin and prevent future contamination or adulteration of this important drug that is administered to several hundred thousand patients each day in the US.,96972,BMBI,Biomaterials and Biointerfaces Study Section,S1,1,12998,
8012515,R01,MH,3,,01/01/2010,02/28/2010,,3R01MH079424-03S2,,NIMH:6802;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PSYCHIATRY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"DULAWA, STEPHANIE C;",2449503;,3R01MH079424,01/01/2010,12/31/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT(1B) Receptor; 5-HT(1Dbeta) Receptor; 5-HT1B Receptor; 5-HT1Dbeta Receptor; 5-Hydroxytryptamine; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-; 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-; 5HT; 5HT transporter; 5HTT protein; Acute; Agonist; Alleles; Allelomorphs; Allergy; Animal Model; Animal Models and Related Studies; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Behavioral Genetics; Benzamide, 4-Chloro-N-(2-(4-morpholinyl)ethyl)-; Binding; Binding (Molecular Function); Brain region; Chlorimipramine; Chronic; Clomipramine; Code; Coding System; Cognitive; Coupling; Demethylimipramine; Desipramine; Desmethylimipramine; Disease; Disorder; Enteramine; Exhibits; Fluoxetin; Fluoxetine; GTP gamma S; GTPgammaS; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinants of Behavior; Genetic Models; Genetic defect; Genetics, Behavioral; Guanosine 5'-(3-O-Thio)Triphosphate; Guanosine 5'-(gamma-S)Triphosphate; Guanosine 5'-(trihydrogen diphosphate), P'-anhydride with phosphorothioic acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippophaine; Human; Human, General; Hypersensitivity; Infusion; Infusion procedures; Investigators; Kanner's Syndrome; Knock-out; Knockout; Knockout Mice; Lead; Levarterenol; Levonorepinephrine; Link; MAO Inhibitors; MAOI; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Missense Mutation; Moclobamide; Moclobemide; Modeling; Models, Genetic; Molecular Interaction; Monoamine Oxidase Inhibitors; Motor; Mouse Strains; Murine; Mus; Mutation; Mutation, Missense; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Noradrenaline; Norepinephrine; Null Mouse; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Pb element; Population; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psyche structure; Receptor Activation; Receptor Protein; Receptor, 5-Hydroxytryptamine 1B; Receptor, Serotonin Type 1Dbeta; Receptor, Serotonin, 5-HT1B; Reflex; Reflex action; Regulation; Research Personnel; Researchers; SSRI; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Sensory; Serotonin; Serotonin 1B Receptor; Serotonin 1D Beta Receptor; Serotonin 1Dbeta Receptor; Specificity; Stimulus; Techniques; Testing; Transgenic Mice; Work; behavior genetics; disease/disorder; effective therapy; gain of function; gain of function mutation; gamma-Thio-GTP; genome mutation; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; insight; mental; model organism; mouse model; mutant; neural mechanism; neuromechanism; novel; overexpression; prepulse inhibition; presynaptic; prevent; preventing; receptor; receptor binding; receptor expression; response; reuptake; serotonin reuptake inhibitor; serotonin transporter; sodium-dependent serotonin transporter; uptake",Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models,,79424,ZRG1,Special Emphasis Panel,S2,3,6802,
8014655,R01,NS,3,,09/01/2009,08/31/2010,PA-07-070,3R01NS018400-25S1,,NINDS:36538;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,PHYSIOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"BORON, WALTER F;",9231563;,3R01NS018400,04/01/1982,08/31/2013,"Acid-Base Balance; Acid-Base Equilibrium; Acidosis, Respiratory; Acids; Affect; Ammon Horn; Aspiration, Respiratory; Assay; Astrocytes; Astrocytus; Astroglia; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Baking Soda; Bicarbonates; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; Biosynthetic Proteins; Blood - brain barrier anatomy; Blood-Brain Barrier; Body Tissues; Brain; Breathing; Calcineurin; Carbonic Acid Monosodium Salt; Cell Line; Cell Lines, Strains; Cell membrane; CellLine; Cells; Cerebrospinal Fluid; Choroid Plexus; Cornu Ammonis; Cot Death; Crib Death; Cytoplasmic Membrane; Cytoplasmic Protein; Data; Deaf; Deletion Mutation; Detergents; Disease; Disorder; Drugs; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Endothelial Cells; Environmental air flow; Epilepsy; Epileptic Seizures; Epileptics; Exons; Extracellular Fluid; Family; Genes; Goals; HCO3; Hard of Hearing Persons; Hearing Impaired Persons; Hemato-Encephalic Barrier; Hippocampus; Hippocampus (Brain); Hydrogen Carbonates; Individual; Inhalation; Inhaling; Insecta; Insects; Inspiration, Respiratory; Invertebrates, Insects; Ion Channel; Ionic Channels; Kanner's Syndrome; Knock-out; Knockout; Knockout Mice; Label; Libraries; Mammals, Mice; Mediating; Medication; Membrane; Membrane Channels; Membrane Proteins; Membrane-Associated Proteins; Memory; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Modification; Molecular; Molecular Interaction; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neuromediator Receptors; Neurons; Neurophysiology / Electrophysiology; Neuroregulator Receptors; Neurotransmitter Receptor; Null Mouse; Oocytes; Ovocytes; PP2B; Persons With Hearing Impairments; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Physiologic; Physiological; Physiology; Plasma Membrane; Play; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Protein Binding; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphatase-2B; Protein phosphatase; Proteins; RNA Splicing; Receptor Protein; Receptors, Neurohumor; Recombinant Proteins; Recombinants; Regulation; Research; Respiratory Acidosis; Role; SIDS; Screening procedure; Seizure Disorder; Seizures; Site; Sodium Bicarbonate; Sodium Hydrogen Carbonate; Splicing; Structure; Structure of choroid plexus; Sudden Infant Death; Sudden Unexpected Death of Infant; Sudden Unexpected Infant Death; Sudden infant death syndrome; Surface Plasmon Resonance; Surface Proteins; Synaptic Transmission; System; System, LOINC Axis 4; Testing; Tissues; Variant; Variation; Ventilation; Work; Xenopus oocyte; base; blind; cultured cell line; disease/disorder; drug/agent; epilepsia; epileptiform; epileptogenic; gene product; hippocampal; hypercapnic acidosis; insight; inspiration; membrane structure; modulator protein; neuronal; neuronal excitability; novel; phosphatase inhibitor 2; phosphoprotein phosphatase inhibitor-2; plasmalemma; protein B; protein phosphatase inhibitor-2; public health relevance; receptor; respiratory; screening; screenings; social role; solid state; spinal fluid; tool; trafficking; uptake",Molecular Physiology of Bicarbonate Transport in the Brain," Transporters that move NaHCO3 (baking soda) into cells-the nNCBTs-play an extremely important role in regulating the acid-base balance of neurons, and in secreting cerebrospinal fluid. Problems with the nNCBTs may contribute to seizure disorders, autism, and disorders of breathing (including SIDS). Two proteins (IRBIT and calcineurin A¨) and an autoinhibitory domain (AID) on the nNCBTs themselves appear to be extraordinarily potent regulators of nNCBT activity. The goal of this project is to understand how the AID, IRBIT, and calcineurin A¨ regulate the nNCBTs; how this regulation impacts the acid-base balance of some neurons that control breathing; and whether disrupting this regulation impacts breathing.",18400,BPNS,Biophysics of Neural Systems Study Section,S1,25,36538,
8014654,R01,NS,3,,01/01/2010,12/31/2010,PA-07-070,3R01NS044057-08S1,,NINDS:21305;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MADISON,UNITED STATES,PHYSIOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"JACKSON, MEYER B.;",1866654;,3R01NS044057,07/01/2002,12/31/2011,"Active Follow-up; Automobile Driving; Biological Models; Bite; Brain; Cell model; Cells; Cellular model; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Critiques; Data Reporting; Distal; Drivings, Automobile; Editorial Comment; Editorial Comment (PT); Encephalon; Encephalons; Exocytosis; Figs; Figs - dietary; Funding; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Grant; Hour; Human Resources; Kinetic; Kinetics; Length; Manpower; Membrane Fusion; Methods; Model System; Modeling; Models, Biologic; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Mutation; NSF attachment protein receptor; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Outcome; PC-12; PC12 Cells; Pheochromocytoma Cell Line; Play; Proteins; Published Comment; Regulation; Reporting, Data; Research; Role; SNAP receptor; SNARE; Speed; Speed (motion); Synapses; Synaptic; Testing; Time; Training; VESCL; Vesicle; Viewpoint; Viewpoint (PT); Work; driving; experiment; experimental research; experimental study; follow-up; gene product; genome mutation; graduate student; insight; neuronal; neurotransmitter release; personnel; pheochromocytoma 12 cell line; pore forming protein; porin; pre-doc; pre-doctoral; predoc; predoctoral; protein complex; research study; response; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor",Single Channel Studies of the Fusion Pore,,44057,BPNS,Biophysics of Neural Systems Study Section,S1,8,21305,
8015471,R01,NS,3,,01/01/2010,12/31/2010,,3R01NS055015-04S1,,NINDS:86231;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,NEUROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"RYE, DAVID B;",1865100;,3R01NS055015,01/20/2007,12/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Adaptive Behaviors; Antibodies; Arousal; Autoregulation; Awareness; Awarenesses; Behavior; Behavioral; Behaviors, Adaptive; Brain; CARTPT gene; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cerebrospinal Fluid; Circadian Rhythms; Clinical; Cocaine and Amphetamine Regulated Transcript; Common Rat Strains; Depressed mood; Disease; Disorder; Diurnal Rhythm; Dopamine; Dose; Drugs; Dystrophia Myotonica; Eating; Encephalon; Encephalons; Endocrine; Excessive Daytime Sleepiness; Excessive daytime somnolence; Exhibits; Food Intake; Fostering; Gelineau Syndrome; Genetic; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Homeostasis; Human; Human, General; Hydroxytyramine; Hypersomnolence, Idiopathic; Hypothalamic structure; Hypothalamus; Idiopathic CNS Hypersomnolence; Idiopathic CNS Hypersomnolences; Idiopathic Central Nervous System Hypersomnolence; Idiopathic Hypersomnia; Idiopathic Hypersomnolence; Idiopathic Hypersomnolences; Impairment; Intracellular Communication and Signaling; Investigators; Lateral; Lead; Locomotion; Macaca mulatta; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Mesencephalon; Metabolic; Mice; Mid-brain; Midbrain; Midbrain structure; Motivation; Murine; Mus; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Narcolepsy; Narcoleptic Syndrome; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurons; Neuropeptides; Nucleus; Nyctohemeral Rhythm; Organism; Paradoxical Sleep; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Paroxysmal Sleep; Pathway interactions; Pattern; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; REM Sleep; Rat; Rattus; Receptor Protein; Regulation; Research Personnel; Researchers; Rewards; Rhesus; Rhesus Macaque; Rhesus Monkey; Rhombencephalic Sleep; Rodent; Rodentia; Rodentias; Role; Rye; Rye cereal; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Deprivation; Sleep Disorders; Sleep, Fast-Wave; Sleep, REM; Steinert Disease; System; System, LOINC Axis 4; Twenty-Four Hour Rhythm; Wakefulness; Wakefulnesses; adaptation behavior; adaptive behavior; alertness; base; biological signal transduction; brain pathway; cholinergic; circadian; circadian process; clinical significance; clinically significant; daily biorhythm; depressed; disease/disorder; diurnal variation; dreaming sleep; drug/agent; feeding; heavy metal Pb; heavy metal lead; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; insight; living system; neurobiological; neuronal; non-human primate; nonhuman primate; orexin; pathway; programs; psychostimulant; rapid eye movement sleep; receptor; sadness; sleep problem; social role; spinal fluid",CART regulation of wakefulness,,55015,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",S1,4,86231,
8015069,R01,NS,3,,07/01/2009,06/30/2010,PAR-08-900,3R01NS064671-02S1,,NINDS:25350;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,BIOCHEMISTRY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"HONG, KYONSOO ;",8383771;,3R01NS064671,07/01/2008,06/30/2013,"Accounting; Assay; Behavior; Bioassay; Biologic Assays; Biological; Biological Assay; Cell Communication and Signaling; Cell Signaling; Cell membrane; Collapsin; Collapsin-1; Collapsing Factor; Computer Analysis; Computer Simulation; Computerized Models; Connector Neuron; Cyclic Nucleotides; Cytoplasmic Membrane; Data; Dependency; Dependency (Psychology); Detection; Development; Embryo; Embryonic; Endoplasmic Reticulum; Environment; Ergastoplasm; Event; Goals; Growth Cones; In Vitro; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Ion Channel; Ionic Channels; Ligands; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Membrane Channels; Membrane Potentials; Methods; Modeling; Models, Computer; Molecular; Monitor; NRVS-SYS; NTN1; NTN1 gene product; NTN1 protein, human; NTN1L; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous system structure; Netrin 1; Netrin 1 Homolog; Neural Cell; Neurites; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Nucleotides, Cyclic; Plasma Membrane; Principal Investigator; Property; Property, LOINC Axis 2; Proteins; Receptor Protein; Receptors, Neurohumor; Reporting; Resting Potentials; Scientist; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Sem D; Sema3A; Semaphorin D; Semaphorin-3A; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; Site; Spinal; Staging; Synapses; Synaptic; Testing; Transmembrane Potentials; V (voltage); Whole-Cell Recordings; Xenopus; base; biological signal transduction; computational analysis; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; emotional dependency; environmental chemical; extracellular; gene product; human NTN1 protein; in silico; in vivo; migration; nervous system development; netrin-1; neural circuit; neural circuitry; neuronal; neurotransmitter release; overexpression; plasmalemma; prevent; preventing; receptor; response; spatiotemporal; trafficking; virtual simulation; voltage",CRCNS: Activity-dependent growth cone guidance,,64671,ZRG1,Special Emphasis Panel,S1,2,25350,
8012044,R01,RR,3,,09/09/2009,05/31/2010,PAR-07-425,3R01RR026040-01S1,,NCRR:25802;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"SIM, IDA ;",6698294;,3R01RR026040,09/09/2009,05/31/2012,"Applications Grants; Architecture; Area; Binding; Binding (Molecular Function); Biomedical Research; California; Cells; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Clinical and Translational Science Awards; Coin; Communities; Complex; Consensus; Custom; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development and Research; Disease; Disorder; Drugs, Nonproprietary; ELIG; Eligibility; Eligibility Determination; Engineering / Architecture; Ensure; Focus Groups; Future; Generic Drugs; Goals; Grant; Grant Proposals; Grants, Applications; Graphical interface; Health; Human; Human, General; Industry; Institution; Intervention; Intervention Strategies; Intervention Studies; Knowledge; Learning; Logic; Man (Taxonomy); Man, Modern; Maps; Methods; Modeling; Molecular Interaction; Observational Study; Ontology; Outcome; Outcome Measure; Owls; Participant; Pathway interactions; Patients; Protocol Screening; R & D; R&D; Research; Research Design; Research Resources; Resources; San Francisco; Scientist; Semantic; Semantics; Services; Source; Strigiformes; Study Type; System; System, LOINC Axis 4; Technology; Terminology; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Universities; Washington; Work; base; biomedical ontology; caBIG; caGrid; cancer Biomedical Informatics Grid; clinical data repository; clinical data warehouse; clinical investigation; data integration; data mining; data modeling; data repository; database design; datamining; design; designing; disease/disorder; fighting; generic; graphic user interface; graphical user interface; human data; improved; interventional strategy; language translation; man; man's; meetings; outreach; pathway; public health relevance; relational database; repository; research and development; sharing data; study design; tool; translation research enterprise; virtual; volunteer",Ontology-Based Integration of Human Studies Data, Project Narrative People volunteer for clinical trials hoping to contribute to public knowledge about what works and what doesn't work to fight disease and to keep us healthy. The information from clinical trials is extremely valuable and scientists should be able to share that information widely so that as many scientists as possible can learn as much as possible from the trials. This project builds a system that allows scientists to share their clinical trial data and to use powerful computing technology to make new discoveries from the shared data,26040,ZRG1,Special Emphasis Panel,S1,1,25802,
8012426,R03,DC,3,Y,01/01/2010,06/30/2010,PAR-07-287,3R03DC008403-03S1,,NIDCD:39530;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHARLESTON,UNITED STATES,OTHER HEALTH PROFESSIONS,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BONILHA, HEATHER SHAW;",8455752;,3R03DC008403,01/01/2010,06/30/2010,"Abscission; Accounting; Address; Advocate; Air Pressure; Animal Welfare; Behavior; Bibliography; Biomechanics; Body Tissues; Bolus; Bolus Infusion; Characteristics; Clinical; Coughing; Country; Data; Deglutition; Diffuse; Dropsy; Ecological impact; Edema; Education; Educational aspects; Environment; Environmental Impact; Equipment; Esthesia; Ethics Committees, Research; Excision; Extirpation; Future; Goals; Habits; Head and Neck, Larynx; Head and Neck, Pharynx; Hydration; Hydration status; Hydrops; Hygiene; IACUC; IRBs; Image Analyses; Image Analysis; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Laryngeal; Laryngeal Diseases; Laryngeal Disorder; Larynx; Larynx Diseases; Lesion; Link; Liquid substance; Location; Measurement; Measures; Mechanics; Medial; Methods; Methods and Techniques; Methods, Other; Modeling; Movement; Mucous body substance; Mucus; National Institute on Deafness and Other Communication Disorders; Nature; Outcomes Research; Participant; Pathology; Patient Care; Patient Care Delivery; Patients; Pattern; Persons; Pharyngeal structure; Pharynx; Pharynxs; Phonation; Physiologic; Physiological; Pressure; Pressure- physical agent; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; ROC Analysis; Relative; Relative (related person); Removal; Reporting; Research; Research Design; Research Ethics Committees; Research Resources; Research Technics; Research, Outcomes; Resources; Sampling; Science of Statistics; Sensation; Specific Gravity; Speed; Speed (motion); Statistics; Stroboscopy; Study Type; Surgical Removal; Swallowing; Swelling; Symptoms; Techniques; Techniques, Research; Thick; Thickness; Throat; Time; Tissues; Treatment Efficacy; True Vocal Cord; United States; Urinary System, Urine; Urine; Vertebrate Animals; Vertebrates; Vibration; Vibration - physical agent; Visual; Vocal Cords; Vocal Fold; Vocal cord structure; Voice; Voice Disorders; abstracting; base; body movement; clinical practice; digital; expectation; expiration; fluid; human subject; image evaluation; in vivo; kinematics; larynx disorder; liquid; mucous; novel; pressure; programs; public health medicine (field); resection; statistics; study design; success; therapeutic efficacy; therapeutically effective; trend; vertebrata; vibration; vocal cord; voice box; voice therapy","Throat Clearing, Coughing, and Alternative Behaviors","Narrative  Four million and eighty thousand persons with voice disorders use habitual  abusive clearing behaviors, which are considered one of the most prevalent forms of  vocal abuse and linked to causing vocal fold lesions. By utilizing digital high-speed  videoendoscopy, stroboscopy, hydration analysis and image analysis techniques, this  research will provide objective data on the dynamics and kinematics of vocal fold  movement and vibration associated with these behaviors, as well as data on alternative  behaviors often advocated for in vocal hygiene education and voice therapy, and the  relationship of both deleterious and ameliorative clearing behaviors with level of  hydration. It is expected that the outcome of this research will be relevant to public  health by increasing our knowledge of behaviors commonly associated with voice  pathology and relating directly to methods of patient care.",8403,ZDC1,Special Emphasis Panel,S1,3,39530,
8016299,R13,NS,3,,09/30/2009,08/31/2010,PA-08-149,3R13NS067914-01S1,,NINDS:15000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PORTLAND,UNITED STATES,NEUROLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"HORAK, FAY BAHLING;NUTT, JOHN G (contact);",1865022;1963465 (contact);,3R13NS067914,09/30/2009,08/31/2010,Achievement; Achievement Attainment; Address; Basic Research; Basic Science; Causality; Clinical; Clinical Investigator; Collaborations; Consensus; Dysfunction; Educational workshop; Equilibrium; Etiology; Fostering; Freezing; Functional disorder; Gait; Goals; Idiopathic Parkinson Disease; Investigators; Lewy Body Parkinson Disease; Link; Locomotion; Neurologic; Neurological; Outcome; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Patients; Physiologic; Physiological; Physiology; Physiopathology; Posture; Primary Parkinsonism; Publishing; QOL; Quality of life; Research; Research Personnel; Researchers; Science; Scientist; Stimulus; Workshop; balance; balance function; base; disease causation; disease etiology; disease/disorder etiology; disorder etiology; effective intervention; falls; improved; interest; meetings; motor control; novel; pathophysiology; public health relevance; theories,Freezing of Gait: From clinical phenomena to basic mechanisms of gait and balance,"PUBLIC HEALTH RELEVANCE: This proposal seeks support for a workshop focusing on freezing of gait in Parkinson's disease. The workshop will explore the clinical phenomenology of freezing of gait, review basic physiology of balance and locomotion that may be related to freezing of gait and review theories about the etiology of freezing of gait. The outcome of this workshop will be a state of the science review of all aspects of freezing of gait intended to serve as a stimulus and guide for further research on the topic.",67914,ZNS1,Special Emphasis Panel,S1,1,15000,
8011852,R15,DK,3,Y,02/01/2010,08/31/2010,PA-03-053,3R15DK069285-01A1S1,,NIDDK:14681;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,OXFORD,UNITED STATES,CHEMISTRY,08,041065129,US,OH,45056,MIAMI UNIVERSITY OXFORD,"HAGERMAN, ANN E;",1866148;,3R15DK069285,02/01/2010,08/31/2010,"2-Phenyl-Benzopyrans; 2-Phenyl-Chromenes; Affinity; Alimentary Canal; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Ascorbic Acid; Assay; Beverages; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Blood; Body Tissues; Cancers; Cardiovascular Diseases; Chemicals; Chemistry; Chemistry, Biological; Data Set; Dataset; Diet; Dietary Polyphenol; Digestive Tract; Disease; Disorder; EGCG; EGCG cpd; Eating; Ensure; Environment; Epigallocatechin Gallate; Epigallocatechingallate; Flavonoids; Food; Food Intake; Free Radical Scavenging; Future; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Goals; Green Tea Extract; Green Tea Polyphenols; Hour; Hydroxyl; Hydroxyl Radical; INFLM; In Vitro; Inflammation; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Kinetic; Kinetics; L-Ascorbic Acid; Life; Ligand Binding Protein; Link; Macrocytes; Macrocytic Red Blood Cell; Macrocytic erythrocyte; Malignant Neoplasms; Malignant Tumor; Modeling; Molecular Interaction; Molecular Weight; Outcome Study; Oxidation-Reduction; Oxidative Stress; Oxis; Pattern; Phase; Plants; Plants, General; Position; Positioning Attribute; Preparation; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding; Proteins; Reaction; Reaction Time; Redox; Research Resources; Resources; Response RT; Response Time; Reticuloendothelial System, Blood; Science of Chemistry; Signaling Molecule; Site; Source; Students; Study, Outcome; Symptoms; Tea catechin; Testing; Time; Tissues; VIT C; Vitamin C; Vitamin E; Vitamins; Work; adduct; adhesive protein (mussel); alimentary tract; anti-oxidant; base; cardiovascular disorder; design; designing; dietary antioxidant; digestive canal; disease risk; disease/disorder; disorder risk; epigallo-catechin gallate; flavanoid; fruits and vegetables; gastrointestinal; gene product; in vivo; lead-binding proteins; malignancy; mussel glue protein; neoplasm/cancer; oxidation reduction reaction; oxidative damage; performance site; polyphenol; polyphenolic protein; programs; protein complex; psychomotor reaction time; residence",Polyphenol-protein antioxidants in the Gl environment,,69285,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,A1S1,1,14681,
8011601,R15,DK,3,Y,02/01/2010,12/31/2010,PA-06-042,3R15DK071588-02S1,,NIDDK:50000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BROCKPORT,UNITED STATES,BIOLOGY,26,152607024,US,NY,14420,COLLEGE AT BROCKPORT,"RICH, ADAM J;",8788860;,3R15DK071588,02/01/2010,12/31/2010,"21+ years old; Adult; Affect; Alimentary Canal; Architecture; Auerbach's Plexus; Binding; Binding (Molecular Function); Biological Models; Body Tissues; Brachydanio rerio; Cell Anatomy; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Anatomy; Cellular Migration; Complex; Connective Tissue; Constipation; Danio rerio; Defect; Development; Digestive Tract; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elements; Engineering / Architecture; Enteral; Enteric; Epithelium; GI Tract; Gastric Stasis; Gastrointestinal Motility; Gastrointestinal Tract; Gastrointestinal tract structure; Gastroparesis; Genetic; Genetics, in situ Hybridization; Health; Human; Human, Adult; Human, General; ICC (Interstitial cell of Cajal); In Situ Hybridization; Interstitial Cell of Cajal; Interstitial cell of Cajal (ICC); Intracellular Communication and Signaling; Isoforms; Leiomyocyte; Ligands; MGF Stem Cell Factor; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor; Membrane; Mice; Model System; Modeling; Models, Biologic; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscle, Involuntary; Muscle, Smooth; Muscular Contraction; Myenteric Plexus; Myocytes, Smooth Muscle; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; PTK Receptors; Patients; Pattern; Phenotype; Physiology; Process; Production; Protein Isoforms; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Steel Factor; Stem Cell Factor; Subcellular Anatomy; Time; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Work; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); alimentary tract; base; biological signal transduction; c-kit Ligand; cell motility; diabetic patient; digestive canal; disease/disorder; dysmotility; dysmotility syndrome; effective therapy; gastrointestinal; in situ Hybridization Staining Method; kit Ligand; membrane structure; motility disorder; mutant; neuronal; novel; progenitor; public health relevance; receptor; receptor function; social role; spatiotemporal",Zebrafish Based Model for Gastrointenstinal Physiology," Project Narrative New model systems are needed to help identify novel drug targets for the effective treatment of gastrointestinal motility disorders such as constipation, gastroparesis, and bloating. This AREA proposal will establish the zebrafish as a model system to study the role of ICC in GI motility, and will contribute to a better understanding of the mechanisms that support ICC development in human health and disease.",71588,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,S1,2,50000,
8006750,R15,DK,3,Y,01/20/2010,04/08/2010,PA-06-042,3R15DK080488-01A1S1,,NIDDK:6729;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,JOHNSON CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,051125037,US,TN,37614,EAST TENNESSEE STATE UNIVERSITY,"STUART, CHARLES A;",1874121;,3R15DK080488,01/20/2010,04/08/2010,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 21+ years old; 5'-AMP-activated protein kinase; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; ATP-protein phosphotransferase; Abdominal obesity; Adult; Aerobic; Affect; Anatomic; Anatomical Sciences; Anatomy; Android fat distribution; Back; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bicycling; Biochemical; Biogenesis; Biopsy, Needle; Blood Glucose; Blood Pressure, High; Blood Sugar; Blood flow; Body Composition; COX1; COX3; Central obesity; Centripetal obesity; Clamping, Glucose; Clinical; Clinical Research; Clinical Study; Conditioning Therapy; Coronary Disease; Coronary heart disease; D-Glucose; DNA, Mitochondrial; Data; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diagnosis; Dorsum; Drugs; Electron Transport; Elements; Enzymes; Epidemic; Euglycaemic Clamp; Euglycemic Clamping; Evaluation; Excess Mortality; Exercise; Exercise, Physical; Fat body with thin limbs; Fats; Fatty acid glycerol esters; Ferricytochrome c; Ferrocytochrome c; Fiber; Gene Targeting; Genes; Genes, Regulator; Glucose; Glucose Binding Protein; Glucose Clamp; Glucose Transporter; Goals; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; HTRPY; Hexose Transporter; Human; Human, Adult; Human, General; Humulin R; Hyperglycemia; Hyperinsulinemia; Hyperinsulinism; Hyperlipemia; Hyperlipidemia; Hypertension; Hypertrophy; Immunoblotting; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intramuscular; Investigators; Isoforms; Knowledge; Lead; Life Expectancy; Life Style; Life Style Modification; Lifestyle; Link; MODY; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measures; Medication; Metabolic syndrome; Methods and Techniques; Methods, Other; Mitochondria; Mitochondrial DNA; Molecular; Muscle; Muscle Cell Contraction; Muscle Cells; Muscle Cells, Mature; Muscle Contraction; Muscle Fibers; Muscle Tissue; Muscular Contraction; Myocytes; Myotubes; NIDDM; Needle biopsy procedure; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; O element; O2 element; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Origin of Life; Over weight; Overweight; Oxygen; PCOX1; PGG/HS; PGHS-1; PGHS1; PHS1; PPAR; PTGHS; PTGS1; PTGS1 gene; Pathway interactions; Pb element; Peptide Biosynthesis, Ribosomal; Peroxisome Proliferator-Activated Receptors; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; Prediabetes; Prediabetes syndrome; Prediabetic State; Prevalence; Prevention; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Isoforms; Protein Kinase; Protein Synthesis, Ribosomal; RAFT-1 gene product; Rapamune; Rapamycin; Recruitment Activity; Regulator Genes; Regulatory Pathway; Research; Research Personnel; Researchers; Resistance; Rhabdomyocyte; Risk; Science of Anatomy; Secure; Sirolimus; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Study Subject; Subcellular Fractions; System; System, LOINC Axis 4; T2D; T2DM; Targetings, Gene; Techniques; Testing; Thigh; Thigh structure; Time; Tobacco Consumption; Tobacco use; Training; Transcriptional Regulatory Elements; Transport Protein, Glucose; Truncal obesity; Type 2 diabetes; Type II diabetes; United States; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; White Fiber; White Muscle Fibers; adiposity; adult human (21+); adult onset diabetes; anatomy; behavior intervention; behavioral intervention; blood glucose regulation; coronary disorder; corpulence; corpulency; corpulentia; cytochrome c; diabetes; diabetes prevention program; drug/agent; electron transfer; excess adiposity in midsection; experience; fasting plasma glucose; glucose control; glucose homeostasis; glucose regulation; glucose uptake; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; high risk; hydroxyalkyl protein kinase; hydroxymethylglutaryl-CoA-reductase kinase; hyperglycemic; hyperpiesia; hyperpiesis; hypertensive disease; improved; insulin resistant; insulin sensitivity; ketosis resistant diabetes; mTOR gene product; mTOR protein; male-type obesity; mammalian target of rapamycin (mTOR); maturity onset diabetes; mitochondrial; mtDNA; novel; obese; obese people; obese person; obese population; pathway; phosphorylase b kinase kinase; pilot study; programs; protein metabolism; protein synthesis; public health relevance; recruit; regulatory gene; resistant; sedentary; strength training; syndrome x; tool; trans acting element; treatment strategy; trunk obesity; uptake; visceral obesity; waist-predominant obesity",Mechanisms by which strength training ameliorates the Metabolic Syndrome,,80488,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",A1S1,1,6729,
7992573,R15,GM,3,Y,01/28/2010,04/30/2011,PA-06-042,3R15GM077192-01A1S1,,NIGMS:58092;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OXFORD,UNITED STATES,OTHER BASIC SCIENCES,08,041065129,US,OH,45056,MIAMI UNIVERSITY OXFORD,"LI, QINGSHUN Q;",7592558;,3R15GM077192,01/28/2010,04/30/2011,"3' Untranslated Regions; 3'UTR; Address; Affect; Animals; Arabidopsis; Arts; Biochemical; Biochemical Genetics; Biological Models; Cells; Cellular biology; Cleavage and Polyadenylation Factors; Complex; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA Molecular Biology; DNA-Dependent RNA Polymerase II; Data; Development; Embryo Development; Embryogenesis; Embryonic Development; Eukaryota; Eukaryote; Female; Gametes; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genetic, Biochemical; Germ Cells; Germ-Line Cells; Goals; Health; Histones; Human; Human, General; Investigators; Link; Man (Taxonomy); Man, Modern; Maps; Messenger RNA; Microarray Analysis; Microarray-Based Analysis; Model System; Models, Biologic; Molecular Biology; Molecular Genetic; Molecular Genetics; Mutation Analysis; Nature; Organism; Play; Poly(A) Tail; Polyadenylation; Pre-mRNA; Process; Proteins; RNA Metabolism[{..}] Processing and Transport; RNA Polyadenylation; RNA Polymerase B; RNA Polymerase II; RNA Processing; RNA, Messenger; RNA, Messenger, Precursors; Reaction; Reproductive Cells; Research; Research Personnel; Researchers; Role; Sex Cell; Specificity; Spermatogenesis; Students; System; System, LOINC Axis 4; Testing; Transcript; Translations; UTRs; Universities; Untranslated Regions; Viral Diseases; Virus Diseases; Work; base; cell biology; disease control; disorder control; domain mapping; endonuclease; eukaryotida; gene function; gene product; genome sequencing; initial cell; interest; living system; mRNA; mRNA Cleavage and Polyadenylation Factors; mRNA Precursor; microarray technology; novel; premRNA; sexual cell; social role; tumor; viral infection; virus infection",The Role of a New Cleavage and Polyadenylation Specificity Factor (CPSF73-II),,77192,ZRG1,Special Emphasis Panel,A1S1,1,58092,
8011385,R15,GM,3,,09/28/2007,08/31/2010,PA-06-042,3R15GM080711-01A1S3,,NIGMS:7646;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CARBONDALE,UNITED STATES,CHEMISTRY,12,939007555,US,IL,629014709,SOUTHERN ILLINOIS UNIVERSITY CARBONDALE,"KOHLI, PUNIT ;",8546805;,3R15GM080711,09/28/2007,08/31/2010,"ATGN; Absorption; Address; Antibodies; Antigens; Area; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Cells; Chemical Structure; Crosslinker; Detection; E coli; Equation; Escherichia coli; FRET; Fluorescence; Fluorescence Resonance Energy Transfer; Genomics; Imagery; Knowledge; Length; Life; Ligands; Liposomal; Liposomes; Mass Spectrum; Mass Spectrum Analysis; Measurement; Microbe; Microscopy; Moab, Clinical Treatment; Molecular; Monoclonal Antibodies; NMR Spectroscopy; Optics; Pansy; Performance; Phase; Photometry/Spectrum Analysis, Mass; Process; Process of absorption; Proteomics; Receptor Protein; Research; Research Support; S. aureus; S.aureus; Solutions; Spectrometry, Mass; Spectroscopy; Spectroscopy, Mass; Spectroscopy, NMR; Spectrum Analyses; Spectrum Analyses, Mass; Spectrum Analysis; Spectrum Analysis, Mass; Spinal Column; Spine; Staphylococcus aureus; Stress; Surface; System; System, LOINC Axis 4; Time; Vertebral column; Viola; Violet; Visualization; Work; absorption; backbone; base; cross-link; crosslink; design; designing; fluorophore; graduate student; immunogen; monomer; novel; nuclear magnetic resonance spectroscopy; particle; polydiacetylene; quantum; receptor; receptor binding; response",Investigating Fluorescence Resonance Energy Transfer in Conjugated Liposomes,,80711,BBM,Biochemistry and Biophysics of Membranes Study Section,A1S3,1,7646,
8005161,R15,GM,3,Y,01/29/2010,12/31/2010,PA-06-042,3R15GM081296-01A1S1,,NIGMS:25000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,079497681,US,PA,19104,UNIVERSITY OF THE SCIENCES PHILADELPHIA,"LI, ZHIYU ;",7760625;,3R15GM081296,01/29/2010,12/31/2010,"Address; Anthrax; Anthrax disease; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; B. anthracis; B. cereus; Bacillus anthracis; Bacillus cereus; Bacteria; Bacterial Spores; Bacterial Typing; Biochemical; Biochemical Genetics; Biological; Biological Function; Biological Process; Characteristics; Chemicals; Complex; DNA; DNA Damage Repair; DNA Helicases; DNA Repair; DNA Structure; DNA Topoisomerase III; DNA Unwinding Proteins; DNA unwinding enzyme; Deoxyribonucleic Acid; E coli; Endocytosis; Enterococcus; Enzymes; Escherichia coli; Eukaryote; Eukaryotic Cell; Exhibits; Fission Yeast; Free Radicals; Genes; Genetic; Genetic, Biochemical; Genome Stability; Germination; Gram-Positive Bacteria; Human; Human Figure; Human body; Human, General; Intermediary Metabolism; Invaded; Light; METBL; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Maps; Metabolic Pathway; Metabolic Processes; Metabolism; Miscellaneous Antibiotic; Molecular; Organism; Pattern; Photoradiation; Plasmids; Process; Property; Property, LOINC Axis 2; Proteins; Racial Segregation; Reproduction spores; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; S cerevisiae; S pombe; Saccharomyces; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Spores; Spores, Bacterial; Stability, Genomic; Staphylococcus epidermidis; Streptococcus enterococcus group; Stress; System; System, LOINC Axis 4; TOP3 topoisomerase; Topo III; Topoisomerase; Topoisomerase III; Typing, Bacterial; UV lesions; Unscheduled DNA Synthesis; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Fission; Yeasts; anthracis; antibiotic design; antibiotic resistant; base; coping; eukaryotida; gene product; helicase; in vivo; insight; living system; pathogen; protein complex; repair; repaired; segregation; tool; ultraviolet lesions",Interaction between B. cereus RecQ helicase and topoisomerase III,,81296,PCMB,Prokaryotic Cell and Molecular Biology Study Section,A1S1,1,25000,
8005156,R15,GM,3,Y,01/07/2010,08/31/2010,PA-06-042,3R15GM083309-02S1,,NIGMS:45000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WASHINGTON,UNITED STATES,BIOLOGY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"WILLIS, KRISTINE AMALEE;",8538769;,3R15GM083309,01/07/2010,08/31/2010,"Assay; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Cancers; Cell Nucleolus; Cell Nucleus; Cell membrane; Cells; Chromatin; Chromosomes; Complex; Congenital Disorders; Cytoplasmic Membrane; D-Glucose; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Dextrose; Disorders, Congenital; Environment; Eukaryota; Eukaryote; Experimental Designs; Figs; Figs - dietary; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, Nitrogen Fixation; Genes, Nitrogen Regulator; Genetic; Genetic Transcription; Glucose; Individual; Investigators; Location; Malignant Neoplasms; Malignant Tumor; Model System; Modeling; Models, Biologic; Monitor; Movement; N element; N2 element; NPC; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nitrogen; Nitrogen Fixation Genes; Nuclear; Nuclear Pore Complex; Nucleus; Organism; Plasma Membrane; Plasmosome; Position; Positioning Attribute; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; RNA Expression; Regulators, Nitrogen; Reporter; Reporting; Research; Research Personnel; Researchers; S cerevisiae; Saccharomyces cerevisiae; Spinocerebellar Ataxia-7; Students; System; System, LOINC Axis 4; Therapeutic; Training; Transcription; Transcription, Genetic; Type 7 Spinocerebellar Ataxia; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; body movement; eukaryotida; gene product; human disease; living system; malignancy; neoplasm/cancer; neurodegenerative illness; nucleolus; plasmalemma; programs",Movement of regulated genes to the nuclear periphery,"The long-term objective of this project is to understand the relationship between the regulation of  gene expression and nuclear substructure. Understanding these and related aspects of gene  regulation is key to the development of effective therapeutics for human diseases, since improperly  regulated transcription is often responsible for congenital disorders and cancer.",83309,NDT,Nuclear Dynamics and Transport,S1,2,45000,
8005169,R15,GM,3,Y,01/20/2010,12/31/2010,PA-06-042,3R15GM087684-01S1,,NIGMS:84880;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,BIOCHEMISTRY,01,111089470,US,NH,038243585,UNIVERSITY OF NEW HAMPSHIRE,"DENIS, CLYDE L;",1880849;,3R15GM087684,01/20/2010,12/31/2010,"3' Untranslated Regions; 3'UTR; 5'-Adenylic acid, homopolymer; Acceleration; Address; Affect; Binding; Binding (Molecular Function); C-terminal; Complex; Decay, mRNA; Defect; Degradation, RNA; Degradation, mRNA; Digestion; Disease; Disorder; Eosinophil cationic protein; Eosinophil-Associated Ribonuclease; Eukaryota; Eukaryote; Free Association; Genetic Alteration; Genetic Change; Genetic defect; Goals; In Vitro; Initiation Factors; L-Proline; Length; Link; Mediating; Messenger RNA; Modeling; Molecular Interaction; Mutation; Nonsense-Mediated Decay; P Domain; P-Type Domain; PAB1 Poly(A) Binding Protein; PABP1 Protein; PABPC1 Protein; Pathway interactions; Peptide Biosynthesis, Ribosomal; Peptide Initiation Factors; Play; Poly A; Poly(A) Tail; Poly(A)-Binding Protein I; Poly(A)-Binding Protein, Cytoplasmic 1; Poly(rA); Process; Production; Proline; Proline-Rich Domain; Proline-Rich Region; Protein Binding; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Public Health; R1 Gene; R2 Gene; RNA Degradation; RNA, Messenger; RNA-Binding Proteins; RNS3 Protein; RNase 3; RR1; RR2 Gene; RRM1; RRM1 gene; RRM2; RRM2 gene; Regulation; Research; Ribonucleoside-Diphosphate Reductase M1 Chain Gene; Ribonucleoside-Diphosphate Reductase M2 Chain Gene; Ribonucleotide Reductase M2 Polypeptide Gene; Ribonucleotide Reductase Small Chain Gene; Ribonucleotide Reductase, Large Subunit Gene; Ribonucleotide Reductase, M1 Subunit Gene; Ribonucleotide Reductase, R1 Subunit Gene; Role; Serum Eosinophil Cationic Protein; Structure; System; System, LOINC Axis 4; TFF Domain; Testing; Translation Initiation Factor; Translational Initiation Factor; Translations; Trefoil Motif; UTRs; Untranslated Regions; Yeasts; analytical ultracentrifugation; disease/disorder; eukaryotida; gene product; genome mutation; in vivo; mRNA; mRNA Decay; mRNA Transcript Degradation; mRNP; messenger ribonucleoprotein; p70 Poly(A) Binding Protein; pathway; polyadenylate; protein expression; protein synthesis; public health medicine (field); public health relevance; social role",Factors affecting mRNA deadenylation, This proposal is relevant to public health by studying how protein expression is controlled. The characterization of the factors that regulate when and to what extent proteins are synthesized will illuminate the processes by which aberrant protein production leads to particular disease states.,87684,MGA,Molecular Genetics A Study Section,S1,1,84880,
7998822,R21,AG,3,,02/01/2010,08/31/2010,PA-06-181,3R21AG034553-01S1,,NIA:68574;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"LUO, GANG ;",8961615;,3R21AG034553,09/15/2009,08/31/2011,"Accidents; Address; Age; Age Factors; Amentia; Applications Grants; Automobile Driving; Blindness; Boxing; Computer Assisted; Control Groups; Data; Dementia; Drivings, Automobile; Evaluation; Evidence based practice guidelines; Eyeglasses; Geographic state; Goals; Grant Proposals; Grants, Applications; Guidelines; Hour; Investigation; Knowledge; Learning; Legal; Licensing; Locales; Maintenance; Maintenances; Measures; Methods; Methods and Techniques; Methods, Other; Monitor; Partial Sight; Patient Self-Report; Pattern; Performance; Physical Health Services / Rehabilitation; Populations at Risk; Procedures; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Questionnaires; Regulation; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Safety; Self-Report; Series; Sight; Specialist; Spectacles; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Techniques; Testing; Time; Training; Training Programs; Transportation; US State; Video Recording; Videorecording; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual Acuity; Visual impairment; Visually Impaired Persons; abstracting; age dependent; age related; base; blind individual; blind people; blind person; computer aided; design; designing; digital; driving; driving behavior; evidence base; evidence based guidelines; evidence based recommendations; experience; experiment; experimental research; experimental study; improved; innovate; innovation; innovative; instructor; meetings; older driver; programs; prototype; public health relevance; rehabilitative; research study; trafficking; video recording system; visually impaired; visually impaired people",Driving performance evaluation based on long term video monitoring of habitual dr," Narrative The results of this exploratory study will provide unprecedented evidence to help driving educators develop evidence-based guidelines and procedures for training visually impaired bioptic drivers. Exploratory findings obtained from this study will be critical for designing further scientific research to implicitly evaluate the value of bioptic telescopes for driving. This study and further research are important in informing low vision rehabilitation and driver licensing, which is not only for the benefits of visually impaired people, but also for the safety of millions of other drivers on the road.",34553,ZRG1,Special Emphasis Panel,S1,1,68574,
8006941,R21,DK,3,Y,02/01/2010,07/31/2010,PA-05-094,3R21DK073720-02S1,,NIDDK:80547;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,,08,623216371,US,NY,10019,ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS,"SHEN, WEI ;",8253229;,3R21DK073720,02/01/2010,07/31/2010,"0-11 years old; 21+ years old; Abdomen; Abdominal; Abdominal obesity; Adipose tissue; Adult; Affect; Age; Android fat distribution; Area; Autoregulation; BMI percentile; BMI z-score; Biological; Blood Plasma; Blood Pressure; Body Composition; Body Tissues; Body Water; Body mass index; Bromides; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Central obesity; Centripetal obesity; Characteristics; Chemotherapy-Hormones/Steroids; Child; Child Youth; Child health care; Childhood; Children (0-21); Clinical Trial Overviews; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; DXA; Data; Data Banks; Data Bases; Data Pooling; Data Poolings; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Deposit; Deposition; Deuterium; Drug or chemical Tissue Distribution; Drugs; Dual-Energy X-Ray Absorptiometry; EMI scan; Endocrine Gland Secretion; Evaluation; Fasting; Fat body with thin limbs; Fats; Fatty Tissue; Fatty acid glycerol esters; Genes; H2 isotope; HDL Cholesterol; Health; Health, Child; Height; High Density Lipoprotein Cholesterol; Homeostasis; Hormones; Human; Human, Adult; Human, Child; Human, General; Humulin R; Hydrogen Oxide; Image; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Investigation; Investigators; Knowledge; Link; Lipids; Lipoproteins, HDL Cholesterol; Location; METBL; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Mesenteric; Mesentery; Meta-Analyses; Meta-Analysis; Metabolic; Metabolic Processes; Metabolism; Methods; Modeling; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Novolin R; Nuclear Magnetic Resonance Imaging; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Pediatrics; Peritoneal; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Plasma; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psyche structure; Puberty; Publishing; Quetelet index; Race; Racial Group; Radiation; Reporting; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Rice; Risk; Role; Sampling; Scanning; Serum, Plasma; Slice; Solutions; Staging; Stocks, Racial; Testing; Therapeutic Hormone; Tissue Distribution; Tissues; Tomodensitometry; Tomography, Xray Computed; Triacylglycerol; Triglycerides; Truncal obesity; Visceral; Water; X-Ray Absorptiometry, Dual-Energy; X-Ray Computed Tomography; Zeugmatography; adipose; adiposity; adult animal; adult human (21+); alpha-Lipoprotein Cholesterol; base; catscan; children; clinical data repository; clinical data warehouse; computed axial tomography; computerized axial tomography; computerized tomography; corpulence; corpulency; corpulentia; data repository; drug/agent; energy balance; excess adiposity in midsection; extracellular; fasted; fasting glucose; fasts; glucose metabolism; human puberty; imaging; imaging modality; improved; indexing; insight; intraperitoneal; male-type obesity; mature animal; mental; model development; obese; obese people; obese person; obese population; obesity risk; pediatric; programs; ray (radiation); relational database; sex; social role; trunk obesity; visceral obesity; waist-predominant obesity; white adipose tissue; yellow adipose tissue; youngster",Central Obesity and Health Risk: Optimal MRI Measurement & Location in Children,,73720,ZRG1,Special Emphasis Panel,S1,2,80547,
8011281,R21,DK,3,Y,02/01/2010,01/31/2011,PA-04-108,3R21DK074477-02S1,,NIDDK:69512;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"HOOGERWERF, WILLEMIJNTJE A;",8348845;,3R21DK074477,02/01/2010,01/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Abdomen; Abdominal; Abdominal Pain; Acetylcholine; Adaptation, Physiological; Adaptations, Physiologic; Address; Affect; Auerbach's Plexus; Biological Rhythm; Biological Rhythm and Oscillation; Body Tissues; Brain; Cell Locomotion; Cell Migration; Cell Movement; Cellular Migration; Cola; Colon; Constipation; Cues; Data; Defecation; Development; Diarrhea; Dysfunction; Electromagnetic, Laser; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Enzymes; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Feces; Functional disorder; Gastrointestinal Physiology; Gastrointestinal Tract, Feces; Gene Expression; Genes; Genus Cola; Goals; Hour; Human; Human, General; Individual; Intervention; Intervention Strategies; Intracolonic; Investigators; Knockout Mice; Lasers; Lead; Liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microscopy; Monitor; Mononitrogen Monoxide; Motility; Motility, Cellular; Murine; Mus; Myenteric Plexus; Nerve Transmitter Substances; Nervous System, Brain; Neurotransmitters; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Null Mouse; Organ; Pathogenesis; Pathway interactions; Pattern; Pb element; Peripheral; Physiologic; Physiological; Physiological Adaptation; Physiopathology; Play; Pressure; Pressure- physical agent; Programs (PT); Programs [Publication Type]; Radiation, Laser; Regulation; Research Personnel; Researchers; Role; Site; Stimulus; Structure of suprachiasmatic nucleus; Suprachiasmatic Nucleus; Time; Tissues; Travel; body system, hepatic; bowel movement; cell motility; day shift; design; designing; dysmotility; dysmotility syndrome; endothelial cell derived relaxing factor; environmental change; feeding; feeding schedule; gastrointestinal; gastrointestinal symptom; heavy metal Pb; heavy metal lead; interventional strategy; light effects; motility disorder; night shift; night work; organ system, hepatic; pathophysiology; pathway; pressure; programs; response; shift work; social role; stool; suprachiasmatic nucleus",Role of clock genes in colonic motility,,74477,ZRG1,Special Emphasis Panel,S1,2,69512,
8011275,R21,DK,3,Y,02/01/2010,01/31/2011,PA-06-181,3R21DK076704-03S1,,NIDDK:99823;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,OBSTETRICS & GYNECOLOGY,05,041438185,US,TN,37208,MEHARRY MEDICAL COLLEGE,"GANGULA, PANDU R;",6568872;,3R21DK076704,02/01/2010,01/31/2011,"2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-; 5,6,7,8-tetrahydrobiopterin; Abdominal Pain; Accounting; Affect; American; Anabolism; Attenuated; BH4; BPH4; Biological; Biopterin; Body Tissues; Body Weight decreased; Cell Locomotion; Cell Migration; Cell Movement; Cellular Migration; Chronic; Clinic; Clinical; Common Rat Strains; Complications of Diabetes Mellitus; Data; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes-Related Complications; Diabetic Complications; Dimerization; Disease; Disorder; Dysfunction; Dyspepsia; Emesis; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enzymes; Event; Experimental Models; Experimental Models, Other; Female; Functional disorder; GTP; Gastric Emptying; Gastric Emptyings; Gastric Stasis; Gastric Tissue; Gastrointestinal Motility; Gastroparesis; Gender Bias; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; H4B; H4biopterin; Health; Humulin R; Hyperglycemia; Impairment; In Vitro; Indigestion; Indigestions; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin, Type I; Lead; MODY; Mammals, Rats; Maturity-Onset Diabetes Mellitus; Mechanics; Mediating; Messenger RNA; Models, Experimental; Molecular; Mononitrogen Monoxide; Motility; Motility, Cellular; Muscle Cell Contraction; Muscle Contraction; Muscular Contraction; NIDDM; NOS 1 protein; NRVS-SYS; Nausea and Vomiting; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurotransmitters; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Pathogenesis; Pathway interactions; Patients; Pb element; Physiopathology; Production; Progressive Disease; Protein Dimerization; RNA, Messenger; Rat; Rat model of diabetes; Rattus; Recurrence; Recurrent; Regulation; Relaxation; Renal Vascular; Renal vessels; Reporting; Retina; Role; STZ; Sex Bias; Sex Characteristics; Sex Differences; Sexism; Solid; Stomach; Streptozocin; Streptozotocin; Structure; Supplementation; Symptoms; Syndrome; T2D; T2DM; THBP; Testing; Tissues; Type 2 diabetes; Type I Insulin; Type II diabetes; Vascular structure of kidney; Vomiting; Weight Loss; Weight Reduction; Woman; Work; Zanosar; adult onset diabetes; base; biosynthesis; body weight loss; cell motility; cofactor; design; designing; diabetes; diabetic; diabetic gastroparesis; diabetic rat; diabetic rat model; dimer; disease/disorder; dysmotility; dysmotility syndrome; endothelial cell derived relaxing factor; enzyme activity; experiment; experimental research; experimental study; gastric; gastrointestinal; gender difference; heavy metal Pb; heavy metal lead; hyperglycemic; in vivo; inhibitor; inhibitor/antagonist; ketosis resistant diabetes; kidney vascular; kidney vascular structure; mRNA; maturity onset diabetes; motility disorder; nNOS enzyme; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal nitric oxide synthase; new therapeutic target; pathophysiology; pathway; protein expression; renovascular; research study; sexual dimorphism (noncellular); social role; stomach emptying; tetrahydro-6-biopterin; tetrahydrobiopterin; wt-loss",Nitric Oxide and gastric motility in female diabetics,,76704,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,S1,3,99823,
8000947,R21,DK,3,Y,01/15/2010,03/31/2011,PA-06-387,3R21DK078863-02S1,,NIDDK:85500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GAINESVILLE,UNITED STATES,PEDIATRICS,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"HALLER, MICHAEL JAMES;",7860807;,3R21DK078863,01/15/2010,03/31/2011,"0-11 years old; APC; ATGN; Activities of Daily Living; Activities of everyday life; Address; Affect; Affinity; Allergy; Animals; Antigen-Presenting Cells; Antigens; Antirejection Therapy; Apoptosis; Apoptosis Pathway; Ascaridil; Attention; Autoantibodies; Autoimmune; Autoimmune Diabetes; Autoimmune Diseases; Autoimmune Process; Autoimmune Responses; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; Blood Glucose; Blood Sugar; Blood granulocytic cell; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-Peptide; CD25; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cancer, Oncology; Candida; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Child; Child Youth; Children (0-21); Clinical; Clinical Trials; Clinical Trials, Unspecified; Colony Stimulating Factor 3; Colony-Stimulating Factor Therapy; Colony-Stimulating Factors; Conflict; Conflict (Psychology); Connecting Peptide; Data; Decaris; Defect; Dendritic Cells; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diathesis; Diet; Disease; Disease Progression; Disease susceptibility; Disorder; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; Effector Cell; Elements; Enrollment; Equilibrium; Equipoise; Eragrostis; Ergamisol; Ergamisole; Event; Eye; Eyeball; FLR; Failure (biologic function); Foundations; Frequencies (time pattern); Frequency; Gastrointestinal Tract, Pancreas; Genetic; Genetic Risk; Glutamate Carboxy-Lyase; Glutamate Decarboxylase; Glutamic Acid Decarboxylase; Glycohemoglobin A; Glycosylated hemoglobin A; Goals; Grafting, Islets of Langerhans; Granular Leukocytes; Granulocyte Colony-Stimulating Factor; Granulocytic cell; Hb A1; Hb A1a+b; Hb A1c; HbA1; HbA1c; Heart; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hemoglobin A(1); Human; Human, Child; Human, General; Humulin R; Hypersensitivity; IA-2-autoantibody; IDD; IDDM; IL2R; IL2RA; IL2RA gene; ITX; Immune; Immune response; Immune system; Immunity; Immunization; Immunol; Immunologic Accessory Cells; Immunologic Factors; Immunologic Stimulation; Immunologic, Immunochemical; Immunological Factors; Immunological Stimulation; Immunologically Directed Therapy; Immunologics; Immunomodulation; Immunomodulators; Immunostimulation; Immunosuppressive Therapy; Immunotherapy; Inbred NOD Mice; Individual; Inducer Cells; Injection of therapeutic agent; Injections; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intracellular Communication and Signaling; Investigation; Islet Cell; Islets of Langerhans Transplantation; Ketrax; Kidney; L-Glutamate-1-carboxy-lyase; Lead; Length of Life; Life; Literature; Longevity; MGI-1 Protein; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medication; Methods; Mice, Inbred NOD; Modeling; Monilia; Monitor; Monocytes / Macrophages / APC; Morbidity; Morbidity - disease rate; Mouse, NOD; Movement; Myeloid Cell-Growth Inducer; Natural History; Nerve; Nervous; Non obese; Non-Obese Diabetic Mice; Nonobese; Nonobese Diabetic Mouse; Novolin R; PBO; Pancreas; Pancreatic; Pathogenesis; Patients; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; Placebo Control; Placebos; Play; Pluripoietin; Population; Predisposition gene; Premature Mortality; Procedures; Process; Production; Protocol; Protocols documentation; Randomized; Regulation; Regulatory T-Lymphocyte; Reporting; Research; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Risk; Role; Safety; Self Tolerance; Self-control as a personality trait; Sensitization, Immunologic; Sensitization, Immunological; Severities; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Solaskil; Study Subject; Subcellular Process; Susceptibility Gene; T-Cell Antigen Receptor Specificity; T-Cell Receptor Specificity; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T1 diabetes; T1D; T1DM; T4 Cells; T4 Lymphocytes; TCGFR; Teff; Tetanus; Therapeutic; Therapeutic Agents; Therapeutic Intervention; Therapeutic immunosuppression; Therapy, Anti-Rejection; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tramisol; Transplantation; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Treatment Efficacy; Trimisol; Type 1 diabetes; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; Veiled Cells; Work; accessory cell; artificial immunosuppression; autoimmune antibody; autoimmune disorder; autoreactive T cell; balance; balance function; base; biological signal transduction; body movement; body system, allergic/immunologic; cell type; children; clinical investigation; clostridial tetanus; daily living functionality; design; designing; diabetes; diabetes control; diabetic; disease risk; disease/disorder; disease/disorder proneness/risk; disorder risk; drug/agent; early childhood; enroll; failure; functional ability; functional capacity; granulocyte; granulocyte colony stimulating factor; heavy metal Pb; heavy metal lead; helper T cell; hemoglobin A1c; host response; immune modulation; immune therapy; immunogen; immunologic reactivity control; immunologic substance; immunological substance; immunoregulation; immunoresponse; immunosuppression; improved; innovate; innovation; innovative; insight; insulin dependent diabetes; interest; intervention therapy; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet transplantation; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; liability to disease; life span; lifespan; mouse model; novel; oncology; organ system, allergic/immunologic; peripheral blood; pilot study; predisposing gene; prevent; preventing; randomisation; randomization; randomly assigned; renal; response; self control; self reactive antibody; self recognition (immune); sham therapy; social role; subcutaneous; therapeutic efficacy; therapeutically effective; thymus derived lymphocyte; tool; transplant; type I diabetes; youngster",Short Course G-CSF as Immunomodulatory Therapy for Type 1 Diabetes ? A Pilot Stud,,78863,ZRG1,Special Emphasis Panel,S1,2,85500,
7988625,R21,DK,3,Y,01/12/2010,01/11/2011,PA-06-157,3R21DK079028-02S1,,NIDDK:114075;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"SKOLNIK, EDWARD Y;",1887546;,3R21DK079028,01/12/2010,01/11/2011,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; 3'5'-cyclic ester of AMP; ADPKD; Active Follow-up; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adult Polycystic Kidney Disease; Adverse effects; Affect; Apical; Autosomal Dominant Polycystic Kidney; Body Tissues; CFTR; CFTR Protein; Calcium-Activated Potassium Channel; Canine Species; Canis familiaris; Cell Count; Cell Line; Cell Lines, Strains; Cell Number; CellLine; Cells; Cellular Expansion; Cellular Growth; Chloride; Chloride Ion; Chlorides; Cl- element; Clinic; Coleonol; Cyclic AMP; Cyst; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Disease Progression; Distal; Dogs; Dominant Polycystic Kidney Disease; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; ESRD; End stage renal failure; End-Stage Kidney Disease; Endopeptidase PC2; Epithelial Cells; Epithelium; Figs; Figs - dietary; Forskolin; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic defect; Growth; Human; Human, General; Hydrogen Oxide; In Vitro; Ion Channels, Potassium; K channel; K+ Channels, Ca2+-Activated; K+ Channels, Calcium-Activated; Kidney; Kidney Failure; Kidney Insufficiency; Kidney Tubules; Lipids; MDCK cell; MTM1 protein; Madin Darby canine kidney cell; Mammals, Dogs; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medication; Membrane Potentials; Messenger RNA; Mice; Movement; Murine; Mus; Mutation; Neuroendocrine Convertase PC1; Neuroendocrine Convertase PC2; Nucleoside diphosphate kinase B; PC1; PC1 Endoprotease; PC1 Prohormone Convertase; PC2; PC2 Endoprotease; PC2 Protein; PC3 Endoprotease; PC3 Prohormone Convertase; PKD1 gene; PKD1 protein; Pathogenesis; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Play; Polycystic Kidney Disease, Autosomal Dominant; Polycystic Kidney, Autosomal Dominant; Potassium Channel; Prohormone Convertase 1; Prohormone Convertase 2; Prohormone Convertase 3; Prohormone Convertase, PC2; Proinsulin Convertase 1; Proinsulin Convertase 2; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertase SPC3; Proteins; RNA, Messenger; RNA, Small Interfering; Regulation; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal function; Renal tubule structure; Resting Potentials; Role; Small Interfering RNA; Sodium Chloride; Sodium chloride (NaCl); Testing; Time; Tissue Growth; Tissues; Transmembrane Potentials; Treatment Side Effects; Urinary System, Kidney; Water; Work; adenosine 3'5' monophosphate; body movement; cAMP; canine; cell growth; cultured cell line; cystic fibrosis transmembrane regulator; domestic dog; driving force; drug/agent; follow-up; gene product; genome mutation; inhibitor; inhibitor/antagonist; kidney function; mRNA; monolayer; mouse model; mutant; myotubularin; ontogeny; overexpression; pcy protein; polycystic breakpoint protein; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 protein; polycystin 1; renal; renal epithelium; renal tubule; salt; siRNA; side effect; social role; therapy adverse effect; treatment adverse effect","The Role of the Calcium Activated Potassium Channel, KCa3.1, in the Pathogenesis ",,79028,CMBK,Cellular and Molecular Biology of the Kidney Study Section,S1,2,114075,
7996282,R21,EY,3,Y,01/01/2010,12/31/2010,EY-07-001,3R21EY018479-02S2,,NEI:159408;,2010,NATIONAL EYE INSTITUTE,,LA JOLLA,UNITED STATES,NONE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"BAIRD, ANDREW ;",1970452;,3R21EY018479,09/30/2007,12/31/2010,"Adsorption; Affect; Animals; Apical; Ascorbic Acid; Autoregulation; Bacteriophages; Binding; Binding (Molecular Function); Biology; Blood; Blood - brain barrier anatomy; Blood Vessels; Blood-Brain Barrier; Brain; Cells; Cerebrospinal Fluid; Choroid Plexus; Choroid Plexus Epithelium; DNA; DNA Molecular Biology; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deoxyribonucleic Acid; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Transport; Drugs; Encephalon; Encephalons; Endothelium; Ependymal Cell; Ependymocyte; Epithelial; Epithelial Cells; Epithelium; Funding; Future; GFAC; Gene Proteins; Genome, Human; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hemato-Encephalic Barrier; Homeostasis; Human Genome; In Vitro; Injection of therapeutic agent; Injections; Intraventricular; Knowledge; L-Ascorbic Acid; Laboratories; Libraries; Ligands; Medication; Medicine; Methods and Techniques; Methods, Other; Mining; Minings; Molecular Biology; Molecular Interaction; Nerve Degeneration; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Peptide Library; Peptide Phage Display Library; Peptides; Phage Display; Phage Display Library, Peptide; Phages; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Physiology; Play; Principal Investigator; Process; Protein Gene Products; Proteins; Receptor Protein; Research; Research Proposals; Reticuloendothelial System, Blood; Role; Science of Medicine; Screening procedure; Selection (Genetics); Specificity; Stromal Cells; Structure of choroid plexus; Subependymal; Techniques; Therapeutic; VIT C; Viral Vector; Vitamin C; bacterial virus; base; cellular targeting; combinatorial; design; designing; disease/disorder; drug/agent; experiment; experimental research; experimental study; gene product; in vivo; intravenous injection; multidisciplinary; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; particle; receptor; research study; screening; screenings; small molecule; social role; spinal fluid; stroke therapy; vascular",Targeting the choroid plexus for drug translocation into CSF,,18479,ZRG1,Special Emphasis Panel,S2,2,159408,
8001038,R21,EY,3,Y,02/01/2010,02/28/2011,PA-06-181,3R21EY018910-02S1,,NEI:114575;,2010,NATIONAL EYE INSTITUTE,,BRONX,UNITED STATES,GENETICS,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"BAKER, NICHOLAS E;",1869113;,3R21EY018910,04/01/2008,02/28/2011,"Abscission; Affect; Anti-Oncogenes; Antioncogenes; Apoptotic; Body Tissues; Cancer Genes; Cancer-Promoting Gene; Cancers; Cell Communication and Signaling; Cell Components; Cell Signaling; Cell Structure; Cell Survival; Cell Transplants; Cell Viability; Cells; Cellular Structures; Drosophila; Drosophila genus; Drosophila melanogaster; Effectiveness; Emerogenes; Excision; Exploratory/Developmental Grant; Extirpation; Fruit Fly, Drosophila; Future; GeneHomolog; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Growth; Growth Disorders; Homolog; Homologous Gene; Homologue; Intracellular Communication and Signaling; Killings; Lead; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Maps; Methods; Methods and Techniques; Methods, Other; Molecular; Mother Cells; Mutation; Natural regeneration; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Pathway interactions; Pb element; Population; Process; Progenitor Cells; R21 Mechanism; R21 Program; Regeneration; Regenerative Medicine; Relative; Relative (related person); Removal; Role; Route; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Surgical Removal; Techniques; Therapeutic; Tissue Growth; Tissues; Transforming Genes; Transplants, Cell; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Work; biological signal transduction; cell type; fruit fly; gene function; genome mutation; heavy metal Pb; heavy metal lead; in vivo; malignancy; neoplasm/cancer; neuronal; novel; oncosuppressor gene; ontogeny; pathway; prevent; preventing; public health relevance; regenerate; repair; repaired; resection; social role; stem; success; tumor suppressor",Cell Competition: Genes That Drive Tissue Replacement,,18910,ZRG1,Special Emphasis Panel,S1,2,114575,
8010072,R21,HD,3,,04/01/2009,03/31/2010,RM-07-004,3R21HD058468-02S1,,NICHD:100129;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"SPIELBERG, FREYA ;",8884912;,3R21HD058468,06/16/2008,03/31/2012,"AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV prevention; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Analysis, Data; Behavioral; Biological; Caring; Client; Clinic; Clinical; Clinical Services; Communities; Computer Assisted; Computer Programs; Computer software; Computers; Confidentiality; Consult; Counseling; Country; Data; Data Analyses; Data Collection; Data Quality; Data Set; Dataset; Diabetes Mellitus; Diagnosis; Documentation; Economics; Engineering; Engineerings; Enrollment; Ensure; Epidemiologist; Epidemiology; Evaluation; Family Violence; Fingerprint; Fingers; Foundations; Funding; Goals; Government; HIV; HIV Prevention; HIV test; HIV/AIDS prevention; HTLV-III; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Incentives; India; Individual; Informatics; Interdisciplinary Research; Interdisciplinary Study; Internet; Interview; Investigators; LAV-HTLV-III; Link; Lymphadenopathy-Associated Virus; Measures; Medical; Method LOINC Axis 6; Methodology; Methodology, Research; Methods; Modification; Multidisciplinary Collaboration; Multidisciplinary Research; Outcome; Participant; Prevention Research; Prevention strategy; Preventive strategy; Printing; Procedures; Process Measure; Programs (PT); Programs [Publication Type]; Public Health; Quality, Data; Reader; Reading; Recommendation; Reporting; Research; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Assessment; Rural; Scientist; Services; Site; Socio-economic status; Socioeconomic Status; Software; Status, Socioeconomic; Stigmata; Study Subject; Study, Interdisciplinary; Technology; Test Result; Testing; Time; Training; United States; Vaccine Research; Vaccines; Validation; Violence, Family; Virus-HIV; WWW; Woman; base; computer aided; computer program/software; diabetes; enroll; experiment; experimental research; experimental study; follow up assessment; follow-up; improved; incentive; inducement; meetings; new technology; outreach; preference; privacy of information; programs; public health medicine (field); research study; skills; social stigma; socioeconomic; socioeconomically; socioeconomics; stigma; tool; web; world wide web","Integration of multi-level behavioral, biological and economic infomatics for HIV",,58468,ZDA1,Special Emphasis Panel,S1,2,100129,
8011156,R24,DK,3,Y,01/20/2010,12/31/2010,DK-06-018,3R24DK064399-07S2,,NIDDK:49945;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"YANG, VINCENT W.;",1939183;,3R24DK064399,01/20/2010,12/31/2010,"Advisory Committees; Ailmentary System; Alimentary Canal; Alimentary System; Area; Biology; C Cell; Cell Culture Techniques; Collaborations; Communicable Diseases; Critical Care; Development; Development and Research; Digestive Diseases; Digestive System; Digestive System (All Sites); Digestive System Diseases; Digestive System Disorders; Digestive Tract; Direct Costs; Endocrinology; Epithelial; Financial Support; Fostering; Funding; GI Tract; Gastrointestinal Body System; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Expression; Goals; Grant; INFLM; Image Analyses; Image Analysis; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Institution; Intention; Investigators; Journals; Lung; Magazine; Medicine; Metabolism and Endocrinology; Mission; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Nephrology; Newsletter; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Gastrointestinal; P01 Mechanism; P01 Program; Parafollicular Cell; Pathology; Pediatric Neurology; Peer Review; Physiology; Play; Productivity; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Publishing; R & D; R&D; ROC Analysis; Research; Research Personnel; Research Program Projects; Research Support; Researchers; Respiratory System, Lung; Role; Schools, Medical; Science of Medicine; Series; Services; Structure of thyroid parafollicular cell; Surgical; Surgical Interventions; Surgical Procedure; Task Forces; Universities; Work; alimentary tract; base; college; conference; cost; digestive canal; digestive disorder; gastrointestinal system; image evaluation; medical schools; meetings; member; programs; pulmonary; research and development; social role; surgery; symposium",Emory Epithelial Pathobiology Research Development Center,,64399,ZDK1,Special Emphasis Panel,S2,7,49945,
8005159,R24,GM,3,Y,01/22/2010,12/31/2010,PA-04-135,3R24GM082910-02S1,,NIGMS:172334;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ITHACA,UNITED STATES,VETERINARY SCIENCES,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"ACLAND, GREGORY M;",1867533;,3R24GM082910,01/22/2010,12/31/2010,"8 year old; Affect; Aggression; Aggressive behavior; Anatomic; Anatomical Sciences; Anatomy; Animal Hospitals; Animal Model; Animal Models and Related Studies; Animals; Applications Grants; Archives; Bar Codes; Behavior; Bio-Informatics; Bioinformatics; Biology; Biomedical Research; Blood Sample; Blood specimen; Breeding; California; Canine Diseases; Canine Species; Canis familiaris; Cataloging; Catalogs; Chromosome Mapping; Clinical; Codes, Bar; Collaborations; Collection; Communities; Complex; Computer Simulation; Computerized Models; Cost Sharing; Crohn's Colitis; Crohn's Disease of Large Intestine; Crohn's disease of large bowel; DNA; DNA Alteration; DNA mutation; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Diagnosis; Diathesis; Disease; Disease susceptibility; Disorder; Dog Diseases; Dogs; Dysplasia; Ensure; Fee-for-Service Plans; Fees for Service; Funding; Future; Gene Alteration; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Mutation; Gene variant; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Diversity; Genetic Heterogeneity; Genetic Models; Genetic Variation; Genetic analyses; Genetic mutation; Genetics, Gene Mapping; Genetics, Medical; Genome; Genomics; Genotype; Goals; Grant; Grant Proposals; Grants, Applications; Granulomatous; HOSP; Haplotypes; Health; Hepatic; Hereditary; Hereditary Disease; Hospitals; Hospitals, Animal; Hospitals, University; Human; Human, General; In element; Indium; Individual; Inherited; Internet; Investigators; Linkage Mapping; Mammalia; Mammals; Mammals, Dogs; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Medical; Medical Genetics; Medicine; Mice; Modeling; Models, Computer; Models, Genetic; Molecular; Molecular Disease; Morphology; Murine; Mus; Pathologic; Patients; Pedigree; Phenotype; Physiologic; Physiological; Pigmentary Retinopathy; Polymorphism, Single Base; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Qualifying; Records; Research Personnel; Research Resources; Researchers; Resources; Retinitis Pigmentosa; Review Committee; Rod-Cone Dystrophy; Role; SNP; SNP Map; SNPs; Sampling; Science of Anatomy; Science of Medicine; Scientist; Screening procedure; Sequence Alteration; Services; Simulation, Computer based; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism Map; Site; Structure; Survey Instrument; Surveys; Tapetoretinal Degeneration; Ulcerated Colitis; Ulcerative Colitis; Universities; University Hospitals; Variant; Variation; Variation (Genetics); Veterinary Clinics; Veterinary Hospitals; Visit; Vocabulary; Vocabulary Words; WWW; allelic variant; anatomy; base; canine; case control; clinical data repository; clinical data warehouse; colitis (granulomatous); computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cost; data repository; density; disease diagnosis; disease/disorder; disease/disorder proneness/risk; domestic dog; dyscrasia; eight year old; empowered; experiment; experimental research; experimental study; genetic analysis; genetic disorder; genetic mapping; genetic pedigree; genome sequencing; genome-wide; hereditary disorder; human disease; in silico; interest; large bowel Crohn's disease; liability to disease; man; man's; model organism; pedigree structure; programs; relational database; repository; research study; screening; screenings; social role; tool; trait; virtual simulation; web; world wide web",Tools for Genetic and Genomic Studies in the Dog,,82910,GCAT,"Genomics, Computational Biology and Technology Study Section",S1,2,172334,
8002969,R25,AI,3,Y,01/15/2010,12/31/2011,PAR-08-003,3R25AI062762-04S1,,NIAID:99869;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,NONE,07,050299031,US,TX,770051892,RICE UNIVERSITY,"MILLER, LESLIE MICHEL (contact);SCHUENKE, KIMBERLY WEISS;",1869653 (contact);9302446;,3R25AI062762,01/15/2010,12/31/2011,"AAAS; American Association for the Advancement of Science; Benchmarking; Best Practice Analysis; Biologic Sciences; Biological Sciences; Causality; Charge; Collaborations; Communicable Diseases; Communicable Diseases, Emerging; Curriculum; Data; Development; Disease; Disorder; Educational Curriculum; Educational process of instructing; Educational workshop; Emerging Communicable Diseases; Ensure; Environment; Etiology; Funding; Goals; Grant; Hand; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Historical Aspects; In element; Indium; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Diseases, Emerging; Infectious Disorder; Internet; Investigators; Journals; Knowledge; Learning; Life Sciences; Link; Magazine; Medical; Microbe; Mission; NIAID; National Institute of Allergy and Infectious Disease; National Research Council; National Research Council (U.S.); On-Line Systems; Online Systems; Parents; Phase; Population; Problem Solving; Process; Publications; Publishing; Research; Research Personnel; Researchers; SCHED; Schedule; School Teachers; Science; Scientific Publication; Scientist; Series; Students; Teachers, School; Teaching; Testing; Texas; Training; Translating; Translatings; Universities; WWW; Work; Workshop; biodefense; career; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; efficacy evaluation; improved; innovate; innovation; innovative; language translation; literacy; meetings; member; middle school; multidisciplinary; next generation; online computer; prevent; preventing; science education; skills; success; teacher; tool; web; web based; web site; world wide web",MedMyst III: Infectious Diseases Materials for Middle School Students,,62762,ZAI1,Special Emphasis Panel,S1,4,99869,
8011258,R25,GM,3,,01/01/2007,12/31/2010,,3R25GM060826-08S2,,NIGMS:251434;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEWARK,UNITED STATES,BIOLOGY,10,130029205,US,NJ,07102,RUTGERS THE STATE UNIV OF NJ NEWARK,"KOMISARUK, BARRY RICHARD;",1875390;,3R25GM060826,01/15/2000,12/31/2010,Baccalaureate Degree; Bachelor's Degree; Biomedical Research; Counseling; Counselor; Doctor of Philosophy; Faculty; Funding; Goals; Master's Degree; Methods; NIH Program Announcements; Participant; Performance; Ph.D.; PhD; Production; Productivity; Professional counselor; Program Announcement; Programs (PT); Programs [Publication Type]; Qualifying; Specific qualifier value; Specified; Students; Training; Training Support; Universities; Work; career; graduate student; improved; meetings; member; programs; response; technical writing,MBRS/IMSD Program at Rutgers-Newark,,60826,ZGM1,Special Emphasis Panel,S2,8,251434,
8011240,R33,EY,3,Y,02/01/2010,01/31/2011,DK-03-019,3R33EY016666-04S1,,NEI:197056;,2010,NATIONAL EYE INSTITUTE,,HERSHEY,UNITED STATES,NEUROSCIENCES,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"ZAGON, IAN S;",1867890;,3R33EY016666,09/30/2004,01/31/2011,"2,4,5,6(1H,3H)-Pyrimidinetetrone; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; Abscission; Adhesions; Alloxan; Animal Experiments; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Biologic Therapy; Biological Response Modifier Therapy; Biological Therapy; Blindness; Blood Glucose; Blood Plasma; Blood Sugar; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; Caliber; Cell Communication and Signaling; Cell Count; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Number; Cell Proliferation; Cell Signaling; Cellular Proliferation; Characteristics; Chronic Disease; Chronic Illness; Cicatrix; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Common Rat Strains; Companions; Complex; Complications of Diabetes Mellitus; Cornea; Corneal Abrasion; Corneal Injury; Corneal Limbus; Corneal Ulcer; Corneoscleral Junction; Corneoscleral Limbus; DNA Replication; DNA Synthesis; DNA biosynthesis; Data; Defect; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetes-Related Complications; Diabetic Complications; Diameter; Dose; Drug Administration, Topical; Du Pont Brand of Naltrexone Hydrochloride; Early-Stage Clinical Trials; Electron Microscopy; Endogenous Opiates; Endothelial Cells; Endothelium; Enkephalins; Epithelial; Epithelium, Anterior Corneal; Epithelium, Corneal; Ethics Committees, Research; Excision; Experiments, Animal; Extirpation; Eye; Eye Drops; Eyeball; Eyedrops; FDA; Fats; Fatty acid glycerol esters; First Gap Phase; Food and Drug Administration; Food and Drug Administration (U.S.); Frequencies (time pattern); Frequency; G1 Phase; G1 period; GFAC; Gap Phase 1; Generalized Growth; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guidelines; Healed; Health; Histology; Humulin R; Hyperglycemia; IDD; IDDM; IRBs; Incidence; Individual; Injection of therapeutic agent; Injections; Injury; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Interruption; Intracellular Communication and Signaling; Intraocular Pressure; Keratitis, Ulcerative; Keratopathy; Kidney Diseases; Lamepro Brand of Naltrexone Hydrochloride; Lesion; Limbus Corneae; Lytotoxicity; Mammals, Rabbits; Mammals, Rats; Measurement; Measures; Microscopy; Modeling; Molecular and Cellular Biology; Monitor; Morbidity; Morbidity - disease rate; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; Nalorex; Naltrexone; Narcotic Antagonists; Necrosis; Necrotic; Nemexin; Nephropathy; Neuropathy; Novolin R; OGF receptor; Ocular Tension; Ophthalmologist; Opiate Antagonist; Opiate Peptides; Opioid; Opioid Antagonists; Opioid Peptide; Opioid Receptor; Orphan Brand of Naltrexone Hydrochloride; Oryctolagus cuniculus; Pain; Painful; Pathogenesis; Pathway interactions; Patients; Perception; Peripheral; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Physiologic Intraocular Pressure; Physiology; Plasma; Population; Rabbit, Domestic; Rabbits; Rat; Rat model of diabetes; Rattus; ReVia; Receptor Protein; Receptors, Opiate; Recurrence; Recurrent; Removal; Renal Disease; Research; Research Ethics Committees; Residual; Residual state; Reticuloendothelial System, Serum, Plasma; Retinal Diseases; Retinal Disorder; STZ; Safety; Scars; Schering-Plough Brand of Naltrexone Hydrochloride; Scientist; Sclerocorneal Limbus; Secure; Serum, Plasma; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Streptozocin; Streptozotocin; Structure; Structure of corneal epithelium; Surgical Removal; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Thick; Thickness; Time; Tissue Growth; Topical application; Toxic effect; Toxicities; Type 1 diabetes; USFDA; United Drug Brand of Naltrexone Hydrochloride; United States Food and Drug Administration; Vitrectomy; Wound Healing; Wound Repair; Zanosar; bench bed side; bench bedside; bench to bed side; bench to bedside; biological signal transduction; biotherapeutics; biotherapy; chronic disease/disorder; chronic disorder; clinical investigation; conjunctiva; cornea ulcer; corneal; corneal epithelial; corneal epithelium; corneal ulceration; corneal wound; cytotoxicity; design; designing; diabetes; diabetes control; diabetic; diabetic patient; diabetic rat; diabetic rat model; dosage; endogenous opioid; enkephalin, Met(5)-Arg(6)-Phe(7) receptor; healing; hyperglycemic; injured; injury, cornea, abrasion; innovate; innovation; innovative; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; kidney disorder; met-enkephalin receptors; methionine-enkephalin receptor; model organism; morphometry; neuropathic; novel; ontogeny; opioid growth factor receptor; pathway; phase 1 study; phase 1 trial; phase I trial; preclinical study; prevent; preventing; protocol, phase I; receptor; receptor, methionine(5)-enkephalin; renal disorder; resection; retina disease; retina disorder; retinopathy; subcutaneous; tissue repair; tonometry; topical administration; topical drug application; topically applied; type I diabetes; type I diabetic",Naltrexone as a Novel Treatment for Diabetic Keratopathy,,16666,ZDK1,Special Emphasis Panel,S1,4,197056,
8002313,R34,DC,3,Y,09/11/2009,08/31/2010,MH-09-173,3R34DC010924-01S1,,NIDCD:95687;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,SANTA BARBARA,UNITED STATES,PSYCHOLOGY,23,094878394,US,CA,93106,UNIVERSITY OF CALIFORNIA SANTA BARBARA,"KOEGEL, ROBERT L;",1965043;,3R34DC010924,09/11/2009,08/31/2011,"0-11 years old; Adaptive Behaviors; Affect; Area; Asses; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavioral; Behaviors, Adaptive; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Child; Child Youth; Children (0-21); Clinic; Clinical Research; Clinical Study; Communication; Competence; Diagnostic; Disease; Disorder; Donkey; Drugs, Nonproprietary; Effectiveness; Effectiveness of Interventions; Environment; Epidemic; Equus asinus; Exhibits; Generalized Growth; Generic Drugs; Growth; Heterogeneity; Human, Child; Intervention; Intervention Strategies; Interview; Journals; Kanner's Syndrome; Laboratories; Language; Literature; Magazine; Measurable; Measures; NIH; National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Normalcy; Normalities; Outcome; Parents; Passeridae; Procedures; Publishing; Randomized Clinical Trials; Research; SCHED; Sampling; Schedule; Semantic; Semantics; Sparrows; Specific qualifier value; Specified; Speech; Staging; Symptoms; Time; Tissue Growth; Trials, Randomized Clinical; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Verbal Behavior; Videotape; Writing; adaptation behavior; adaptive behavior; behavior rating scale; behavioral rating scale; children; comparison group; cooking; disease/disorder; effect of intervention; generic; improved; interventional strategy; ontogeny; post intervention; public health relevance; reinforcer; response; social; social communication; syntactic; syntax; treatment as usual; youngster",Child-Initiated Communicative Interactions and Autism Intervention," Child-Initiated Interactions and Autism Intervention B. PROJECT NARRATIVE  The Center for Disease Control has declared autism as an epidemic affecting 1 in 150 children, and is an NIH priority area. The proposed project will examine specific intervention components during language intervention and social communication. The study will assess improvements on the condition of autism.",10924,ZMH1,Special Emphasis Panel,S1,1,95687,
8010991,R37,DK,3,Y,01/15/2010,12/31/2010,,3R37DK015556-39S1,,NIDDK:126676;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAMPAIGN,UNITED STATES,CHEMISTRY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"KATZENELLENBOGEN, JOHN A.;",1881308;,3R37DK015556,01/15/2010,12/31/2010,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Agonist; Anti-Estrogens; Antiestrogens; Area; Assay; Authorization; Authorization documentation; Back; Binding; Binding (Molecular Function); Binding Proteins; Binding Site Domain; Bioassay; Biocompatible Materials; Biologic Assays; Biological Assay; Biology; Biomaterials; Cancer of Breast; Cell Communication and Signaling; Cell Signaling; Chemicals; Contracting Opportunities; Contracts; Development; Disclosure; Dorsum; Environment; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; FRET; Face; Fluorescence; Fluorescence Resonance Energy Transfer; Funding; Generations; Genome; Glass; Goals; Grant; High Throughput Assay; Human Resources; Illinois; Information Disclosure; Instruction; Intracellular Communication and Signaling; Investigation; LRET; Last Name; Lead; Length; Ligand Binding; Ligand Binding Domain; Ligand Binding Protein; Ligands; Malignant Tumor of the Breast; Malignant neoplasm of breast; Manpower; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Models, Molecular; Molecular; Molecular Interaction; Molecular Models; Molecular Probes; NIH; Names; National Institutes of Health; National Institutes of Health (U.S.); Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nuclear Receptors; Nucleic Acid Biochemistry, Molecular Modeling; Organ; Pb element; Permission; Pharmacology; Principal Investigator; Printing; Programs (PT); Programs [Publication Type]; Progress Reports; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Biochips; Protein Chips; Protein Dynamics; Protein Microarray; Protein Microchips; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; R01 Mechanism; R01 Program; RPG; Receptor Protein; Receptors, Steroid; Regulation; Reports, Progress; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resistance; Role; SERMs; Selective Estrogen Receptor Modulators; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slide; Steroid Receptors; Structure; System; System, LOINC Axis 4; TAM; Tamoxifen; Techniques; Therapeutic Estrogen; Trustees; United States National Institutes of Health; Universities; Vision; Work; antiestrogen; antiestrogenic; base; biological signal transduction; combinatorial; design; designing; drug discovery; estrogen inhibitor; facial; fluorophore; gene product; genome-wide; heavy metal Pb; heavy metal lead; high throughput screening; improved; in vivo; inhibitor; inhibitor/antagonist; luminescence resonance energy transfer; malignant breast neoplasm; molecular modeling; novel; personnel; programs; protein protein interaction; receptor; receptor density; receptor function; resistant; small molecule; social role; tool",MOLECULAR PROBES FOR STEROID RECEPTORS,,15556,NSS,,S1,39,126676,
8012973,R37,DK,3,Y,01/28/2010,12/31/2010,,3R37DK027619-26S1,,NIDDK:262416;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"BERGMAN, RICHARD NATHAN;",1880598;,3R37DK027619,01/28/2010,12/31/2010,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; ACRP30 protein; AKT; Abnormal Assessment of Metabolism; Adipocytes; Adipose Cell; Adipose tissue; Akt protein; Animals; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood; Blood Plasma; Calories; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Signaling; Cells; Chronic Disease; Chronic Illness; Conscious; Consciousness; D-Glucose-6-phosphate phosphohydrolase; Defect; Deposit; Deposition; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Differentiation Factor, B-Cell; Disease; Disorder; Dogs; Dose; Dysfunction; Enzymes; Exhibits; Extremities; Fat Cells; Fats; Fatty Acids, Nonesterified; Fatty Tissue; Fatty acid glycerol esters; Free Fatty Acids; Functional disorder; Funding; Gastrointestinal Tract, Pancreas; Genes; Glucose-6-Phosphate Phosphohydrolase; HPGF; Hepatic; Hepatocyte-Stimulating Factor; Hour; Humulin R; Hybridoma Growth Factor; Hyperinsulinemia; Hyperinsulinism; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Limb structure; Limbs; Link; Lipids; Lipocytes; Lipolysis; Liver; Lymphocyte-Stimulating Hormone; MGI-2; MODY; Macrophage Cell Factor; Mammals, Dogs; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Metabolic Studies; Metabolic syndrome; Metabolism Studies; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Myeloid Differentiation-Inducing Protein; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-Trunk; Nonesterified Fatty Acids; Novolin R; Obesity; Omental Fat; Omentum; Organ; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); PAI-1; PAI1; PEPCK; PKB protein; PLANH1; Pancreas; Pancreatic; Pathogenesis; Peripheral; Peripheral Resistance; Phosphoenolpyruvate Carboxylase; Physiologic; Physiological; Physiopathology; Plasma; Plasmacytoma Growth Factor; Plasminogen Activator Inhibitor 1; Play; Protein Kinase B; Proto-Oncogene Proteins c-akt; RAC-PK protein; Relative; Relative (related person); Resistance; Resistance, Total Peripheral; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Retroperitoneal; Retroperitoneal Cavity; Retroperitoneal Space; Retroperitoneum; Risk; Role; SNS; SRE-1 binding protein; SREBP-1; STZ; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Skeletal Muscle Tissue; Skeletal muscle structure; Societies; Source; Streptozocin; Streptozotocin; Sympathetic Nervous System; Syndrome; T Helper Factor; T2D; T2DM; Testing; Time; Triacylglycerol; Triglycerides; Type 1 Plasminogen Activator Inhibitor; Type 2 diabetes; Type II diabetes; Vascular Resistance, Systemic; Visceral; Work; Zanosar; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adipose; adiposity; adult onset diabetes; apM-1 protein; apM1 (adipose-specific) protein; base; biological signal transduction; body system, hepatic; c-akt protein; calorie (nutrition); canine; chronic disease/disorder; chronic disorder; corpulence; corpulency; corpulentia; diabetic; disease/disorder; domestic dog; glucose-6-phosphatase; insulin resistant; insulin signaling; interferon beta 2; interventional strategy; intraperitoneal; islet; ketosis resistant diabetes; lymphocyte activating factor; mRNA Expression; man; man's; maturity onset diabetes; metabolic abnormality assessment; obese; obese people; obese person; obese population; organ system, hepatic; pathophysiology; phosphoenolpyruvate carboxykinase; prevent; preventing; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; resistant; resistin; saturated fat; social role; sterol regulatory element-binding protein 1; subcutaneous; white adipose tissue; yellow adipose tissue",Quantitative Studies of Metabolic Organ Dynamics,,27619,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,26,262416,
8011278,R37,DK,3,Y,02/01/2010,12/31/2010,,3R37DK030292-28S1,,NIDDK:106152;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,ANATOMY/CELL BIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"GORDON, JEFFREY IVAN;",2414084;,3R37DK030292,02/01/2010,12/31/2010,"21+ years old; Active Follow-up; Adipocytes; Adipose Cell; Adult; Age; Anaerobic Bacteria; Animals; Archaea; Archaebacteria; Archaeobacteria; Archaeon; B. thetaiotaomicron; B.thetaiotaomicron; Bacillus thetaiotaomicron; Bacteria; Bacteria, Anaerobic; Bacteroides; Bacteroides thetaiotaomicron; Bacteroidetes; Behavior; Binding Proteins; Biochemical; Biochemical Genetics; Biology; Birth; Body Surface; Cancer Causing Agents; Cancers; Carcinogens; Chemicals; Colon; Communities; Comparative Study; Consumption; Cristobalite; Custom; Data Set; Dataset; Development; Diarrhea; Diet; Dietary Polysaccharide; Disease; Disorder; Distal; Ecologic Systems; Ecosystem; Educational process of instructing; Electromagnetic, Laser; Epithelial Cells; Epithelium; Eubacterium; Face; Fat Cells; Fats; Fatty acid glycerol esters; Food; Foundations; Fructans; Gametes; Gene Expression Profile; Genes; Genetic; Genetic analyses; Genetic, Biochemical; Genome; Genomics; Germ Cells; Germ-Free; Germ-Line Cells; Glycans; Glycohydrolases; Glycosidases; Glycoside Hydrolases; Gnotobiotic; Gnotobiotics; Goals; Grant; Habitats; Harvest; Health; Hexoses; Human; Human, Adult; Human, General; Immune system; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intestinal; Intestines; Investigators; Lasers; Learning; Levans; Life; Ligand Binding Protein; Lipocytes; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Membrane; Metabolic; Metabolic Pathway; Methanobacteria; Methanobrevibacter; Mice; Microbe; Microorganisms, General; Microscopy, Electron, Scanning; Modeling; Molecular; Monitor; Mucous body substance; Mucus; Murine; Mus; Nature; Nutrient; Obesity; Oncogens; Operation; Operative Procedures; Operative Surgical Procedures; Organism; Parturition; Pathway interactions; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiology; Polysaccharides; Population; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publishing; Radiation, Laser; Reagent; Reporting; Reproductive Cells; Research Personnel; Researchers; Role; S. thetaiotaomicron; S.thetaiotaomicron; Sand; Sex Cell; Shapes; Signal Pathway; Silica; Silicon Dioxide; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sphaerocillus thetaiotaomicron; Surgical; Surgical Interventions; Surgical Procedure; Symbiosis; Systems, Ecological; Teaching; Testing; Therapeutic; Time; Tridymite; Xenobiotics; adiposity; adult human (21+); anaerobe; base; body system, allergic/immunologic; bowel; commensalism; corpulence; corpulency; corpulentia; disease/disorder; experiment; experimental research; experimental study; facial; feeding; follow-up; functional genomics; gene expression signature; genetic analysis; genome sequencing; genome-wide; gut microbiota; in vivo; initial cell; insight; living system; malignancy; measurement of metabolism; member; membrane structure; metabolomics; methanogen; microbial; microbial community; microbial host; microbiome; microorganism; mouse model; mucous; mutualism; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; organ system, allergic/immunologic; particle; pathway; programs; reconstruction; research study; response; sensor; sexual cell; social role; sugar; surgery; trait; transcriptome",Genomic and metabolomic foundations of human-microbial symbiosis in the gut,,30292,GMPB,Gastrointestinal Mucosal Pathobiology Study Section,S1,28,106152,
8004368,R37,DK,3,Y,02/01/2010,04/30/2010,,3R37DK033651-27S1,,NIDDK:93656;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"OLEFSKY, JERROLD MICHAEL;",1865678;,3R37DK033651,02/01/2010,04/30/2010,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adipocytes; Adipose Cell; Agonist; Binding; Binding (Molecular Function); Biochemical; Biology; Cell Communication and Signaling; Cell Signaling; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Endothelin; Endothelium-Derived Vasoconstrictor Factors; Event; Fat Cells; GLUT4; GLUT4 gene; Gene Targeting; Goals; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Human; Human, General; Humulin R; INSR; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Resistance; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Knowledge; Lead; Lipocytes; MODY; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Method LOINC Axis 6; Methodology; Molecular; Molecular Interaction; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nuclear Receptors; PI-3 Kinase; PI-3K; PI3-Kinase; Pb element; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Physiologic; Physiological; Process; PtdIns 3-Kinase; Receptor Protein; Receptor Signaling; Research Proposals; Resistance; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; System; System, LOINC Axis 4; T2D; T2DM; Targetings, Gene; Testing; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; adult onset diabetes; biological signal transduction; desensitization; diabetic; diabetic patient; disease/disorder; experiment; experimental research; experimental study; glucose transport; heavy metal Pb; heavy metal lead; improved; insulin resistant; interest; ketosis resistant diabetes; knockout animal; man; man's; maturity onset diabetes; novel; receptor; research study; resistant; social role",INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM,,33651,NSS,,S1,27,93656,
8001225,R37,DK,3,Y,01/15/2010,12/31/2010,,3R37DK033823-28S1,,NIDDK:235500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"PESSIN, JEFFREY E;",6203110;,3R37DK033823,01/15/2010,12/31/2010,"4B4 Antigen; Actins; Adipocytes; Adipose Cell; Alleles; Allelomorphs; Assay; Band 2 Protein; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological; Biological Assay; CD29 Antigen; CDw29 Antigen; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Caveolae; Caveolas; Caveolin Proteins; Caveolins; Cell Communication and Signaling; Cell Membrane Lipids; Cell Signaling; Cell membrane; Cells; Chimera Protein; Chimeric Proteins; Complex; Cytoplasmic Membrane; Data; Diffusion; Docking; EC 2.7; Extracellular Matrix, Integrins; F-Actin; Fat Cells; Filamentous Actin; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Fusion Protein; GLUT4; GLUT4 gene; Goals; H-Ras Protein; HRAS; Ha-ras Protein; Humulin R; INSR; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Integrin beta1; Integrins; Intracellular Communication and Signaling; Kinases; Knockout Mice; Lateral; Ligand Binding Protein; Lipid Rafts, Cell Membrane; Lipocytes; Mammals, Mice; Mature Lipocyte; Mature fat cell; Mediating; Membrane; Membrane Fusion; Membrane Lipids; Membrane Microdomains; Membrane Proteins; Membrane-Associated Proteins; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microtubules; Molecular Interaction; Murine; Mus; NSF attachment protein receptor; Novolin R; Null Mouse; PKC; Pathway interactions; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphotransferases; Plasma Membrane; Play; Process; Protein Kinase C; Protein Phosphorylation; Proteins; PtdINS4P; RNA, Small Interfering; Reaction; Receptor Protein; Regulation; Regulatory Protein; Research Proposals; Role; SNAP receptor; SNARE; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; Stxbp4 protein, mouse; Surface Proteins; Synip protein, mouse; Talin; Testing; Transmission; Transphosphorylases; VAMP3; VESCL; Vesicle; adipocyte development; adipocyte differentiation; biological signal transduction; c-Ha-ras p21; cellubrevin; computerized data processing; data processing; depolymerization; experiment; experimental research; experimental study; gene product; genetic regulatory protein; homologous recombination; in vivo; insulin signaling; lipid raft; membrane structure; mouse Stxbp4 protein; mutant; p21 H-Ras Protein; p21 c-H-ras; p21 ha-ras; pathway; phosphatidylinositol 4-monophosphate; phosphatidylinositol 4-phosphate; plasmalemma; polymerization; prevent; preventing; receptor; reconstitute; reconstitution; regulatory gene product; research study; scaffold; scaffolding; siRNA; signal processing; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; synip; syntaxin 4; syntaxin binding protein 4, mouse; t-SNARE; target SNARE proteins; target membrane SNARE proteins; trafficking; transmission process; v-SNAREs; vesicle-associated membrane protein 3; vesicular SNARE proteins; vesicule SNARE proteins",Intracellular signaling by the insulin receptor kinase,,33823,CADO,Cellular Aspects of Diabetes and Obesity Study Section,S1,28,235500,
8004337,R37,DK,3,Y,01/26/2010,11/30/2010,,3R37DK037175-26S1,,NIDDK:100001;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"MITCH, WILLIAM EVANS;",1873265;,3R37DK037175,01/26/2010,11/30/2010,"1-Phosphatidylinositol 3-Kinase; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Apopain; Atrophy, Muscle; BZS; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Signaling; Chronic Kidney Failure; Chronic Renal Disease; Complex; Cysteine Protease CPP32; Degradation Pathway; Degradative Pathway; Down-Regulation; Down-Regulation (Physiology); Downregulation; Enzymes; Exhibits; Experimental Models; Experimental Models, Other; Glucocorticoids; Goals; Grant; HMG-20; High Mobility Protein 20; Humulin R; IGF-1; IGF-1 Receptor; IGF-I; IGF-I-SmC; IGF1; IGF1R; INSR; IRS-1 protein; IRS1; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Receptor Substrate 1; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor 1 Receptor; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Insulin-Like-Growth Factor I Receptor; Intermediary Metabolism; Intracellular Communication and Signaling; Kidney Failure; Kidney Failure, Chronic; Kidney Insufficiency; METBL; MHAM; MMAC1; Macropain; Macroxyproteinase; Mammals, Mice; Mediating; Metabolic Processes; Metabolic acidosis; Metabolism; Mice; Mice, Transgenic; Modeling; Models, Experimental; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multicatalytic Proteinase; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Proteins; Muscle Tissue; Muscular Atrophy; Myocytes; Myofibrils; Novolin R; Nutrition; Nutritional Science; PARP Cleavage Protease; PI-3 Kinase; PI-3K; PI3-Kinase; PTEN; PTEN gene; PTEN1; Pathway interactions; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Physiologic; Physiological; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Cleavage; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteolysis; Proteosome; PtdIns 3-Kinase; Receptor Protein; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Renal Failure; Renal Failure, Chronic; Renal Insufficiency; Role; SCA-1; SREBP Cleavage Activity 1; Science of nutrition; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Somatomedin C; Structure; System; System, LOINC Axis 4; Testing; Therapeutic Glucocorticoid; Transgenic Mice; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Ubiquitin; Uremia; Uremias; Yama; Yama protein; base; biological signal transduction; caspase-3; chronic kidney disease; combat; cysteine protease P32; gene product; in vivo; insulin receptor substrate 1 protein; multicatalytic endopeptidase complex; muscle form; muscular structure; novel; nutrition; pathway; prevent; preventing; protein degradation; receptor; response; social role; uremia of renal origin; wasting",Protein Nutrition in Experimental Uremia,,37175,PBKD,Pathobiology of Kidney Disease Study Section,S1,26,100001,
8010993,R37,DK,3,Y,01/15/2010,03/31/2010,PA-07-070,3R37DK043806-19S2,,NIDDK:99500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LAZAR, MITCHELL A.;",1892096;,3R37DK043806,01/15/2010,03/31/2010,"21+ years old; Adult; Affect; Arts; Biological; Body Tissues; Cancers; Cardiovascular Diseases; Cell Culture Techniques; Chemotherapy-Hormones/Steroids; Chromatin; Complex; Data; Deacetylase; Development; Diabetes Mellitus; Embryo; Embryonic; Endocrine Gland Secretion; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Funding; Gene Down-Regulation; Gene Expression; Gene Targeting; Gene Transcription; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; HDAC; HDAC Proteins; HDAC3; HDAC3 enzyme; Histone Deacetylase; Hormone Receptor; Hormones; Human, Adult; INFLM; In Vitro; Inflammation; Intermediary Metabolism; Isoforms; Knock-out; Knockout; Knockout Mice; Laboratories; Lead; Ligands; Light; METBL; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolism; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modeling; Murine; Mus; Mutant Strains Mice; Mutation; Nuclear Receptors; Null Mouse; Obesity; Pathway interactions; Pb element; Phenocopy; Phenotype; Photoradiation; Physiologic; Physiological; Point Mutation; Property; Property, LOINC Axis 2; Protein Isoforms; RNA Expression; Regulation; Repression; Role; Silencing Mediator of Retinoid Thyroid Receptor; Specificity; Targetings, Gene; Technology; Testing; Therapeutic Hormone; Therapeutic Intervention; Thesaurismosis; Thyroid Hormone Receptor; Time; Tissues; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Transgenic Organisms; Work; adiposity; adult human (21+); base; cardiovascular disorder; corpulence; corpulency; corpulentia; diabetes; gene repression; genome mutation; heavy metal Pb; heavy metal lead; histone deacetylase 3; in vivo; innovate; innovation; innovative; insight; intervention therapy; malignancy; member; metabolism disorder; mouse mutant; mutant; neoplasm/cancer; novel; obese; obese people; obese person; obese population; pathway; prevent; preventing; receptor function; recombinase; social role; transgenic",Thyroid hormone receptors - regulation and function,,43806,MCE,Molecular and Cellular Endocrinology Study Section,S2,19,99500,
8004598,R37,DK,3,Y,01/15/2010,04/30/2010,PA-03-156,3R37DK051729-14S1,,NIDDK:42201;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,071723084,US,MA,02215,JOSLIN DIABETES CENTER,"SHOELSON, STEVEN E;",1862750;,3R37DK051729,01/15/2010,04/30/2010,"APF-1; ATP-Dependent Proteolysis Factor 1; Adenoviral Vector; Adenovirus Vector; Animal Model; Animal Models and Related Studies; Animals; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor Gene; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor 2 Gene; B-Cell Stimulatory Factor-2; BB2; BCDF; BSF-2; BSF-2 Gene; BSF2; BSF2 (B cell stimulating factor 2); BSF2 Gene; Binding; Binding (Molecular Function); Body Tissues; Bp50; CD40; CD54; CDW40; COX-2; COX2; Cachectin; Cachectin Receptors; Cachectin-Tumor Necrosis Factor; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Clamping, Glucose; Cultured Cells; D-Glucose; Data; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Differentiation Factor, B-Cell; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7; Energy Expenditure; Energy Metabolism; Euglycaemic Clamp; Euglycemic Clamping; Fasting; Fats; Fatty Acids, Nonesterified; Fatty acid glycerol esters; Feedback; Free Fatty Acids; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Targeting; Gene Transcription; Genetic Transcription; Glucose; Glucose Clamp; Grant; HMG-20; HPGF; HSF Gene; Hepatocyte Stimulatory Factor Gene; Hepatocyte-Stimulating Factor; High Mobility Protein 20; Host Defense; Human; Human, General; Humulin R; Hybridoma Growth Factor; Hybridoma Growth Factor Gene; I Kappa B A; I Kappa B-Alpha; I kappa B-alpha protein; I-kappa B; I-kappa B Proteins; ICAM-1 Gene; ICAM1; ICAM1 gene; IFN-beta 2; IFNB2; IFNB2 Gene; IKB; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IL-6; IL-6 Gene; IL6; IL6 Protein; IL6 gene; INFLM; IkappaBalpha; Immunoglobulin Enhancer-Binding Protein; Inflammation; Inflammatory; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Interferon, Beta-2 Gene; Interleukin 6 (Interferon, Beta 2); Interleukin 6 (Interferon, Beta 2) Gene; Interleukin-6; Interleukin-6 Gene; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Kinases; Knock-out; Knockout; Leptin; Link; Lipids; Liver; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; MGC9013; MGC[{..}]3310; MGI-2; MODY; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic syndrome; Methods; Mice; Mice, Transgenic; Modeling; Molecular Interaction; Murine; Mus; Muscle; Muscle Tissue; Myeloid Differentiation-Inducing Protein; NF-Kappa B Inhibitor; NF-Kappa B Inhibitor Alpha; NF-kB; NF-kappa B; NF-kappaB; NF-kappaB inhibitor alpha; NFKB; NFKB Inhibitor; NFKBI; NFKBIA; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Novolin R; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Nuclear Transcription Factor NF-kB; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Organ; PAI-1; PAI1; PGG/HS; PGHS-2; PHS-2; PLANH1; PTGS2; PTGS2 gene; Pathogenesis; Pathway interactions; Patients; Phenotype; Phosphorylation; Phosphotransferases; Plasmacytoma Growth Factor; Plasminogen Activator Inhibitor 1; Production; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Turnover; Proteins; RNA Expression; RNA, Small Interfering; Research Personnel; Researchers; Rodent; Rodent Model; Rodentia; Rodentias; Role; SAA-1; Scanning; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Small Interfering RNA; T2D; T2DM; TNF; TNF Alpha; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptor-Associated Factor 6 Gene; TNF Receptors; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFR; TNFRSF5; TNFRSF5 gene; TNFSF2 protein, human; TRAF6; TRAF6 gene; Targetings, Gene; Technology; Testing; Therapeutic Intervention; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Transgenic Mice; Transgenic Organisms; Transphosphorylases; Triacylglycerol; Triglycerides; Tumor Necrosis Factor; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Type 1 Plasminogen Activator Inhibitor; Type 2 diabetes; Type II diabetes; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Up-Regulation; Up-Regulation (Physiology); Upregulation; adeno vector; adenovector; adiposity; adult onset diabetes; atheromatosis; atherosclerotic vascular disease; biological signal transduction; body system, hepatic; cardiovascular disorder; corpulence; corpulency; corpulentia; cytokine; experiment; experimental research; experimental study; fasted; fasts; gene product; hCOX-2; human TNF protein; improved; in vivo; inflammatory marker; inhibitor; inhibitor/antagonist; insulin resistant; insulin sensitivity; insulin signaling; interest; interferon beta 2; intervention therapy; interventional strategy; kappa B Enhancer Binding Protein; ketosis resistant diabetes; maturity onset diabetes; model organism; nuclear factor kappa beta; ob/ob mouse; obese; obese people; obese person; obese population; organ system, hepatic; p40 protein (IkappaB-alpha); p50; pathway; programs; protein degradation; research study; resistin; salicylate; siRNA; social role; sperm acrosomal antigen 1; sperm acrosome antigen-1; transcription factor; transgenic; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; ubiquination; ubiquitin conjugation",Mediators and Modifiers of NF-kappaB in Insulin Resistance,,51729,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,S1,14,42201,
8009585,R37,DK,3,Y,01/15/2010,03/31/2010,,3R37DK053301-13S1,,NIDDK:98440;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"ELMQUIST, JOEL K;",1900083;,3R37DK053301,01/15/2010,03/31/2010,"Adipose Tissue, Brown; Agonist; Alleles; Allelomorphs; Anorexia Nervosa; Attenuated; B9 endocrine pancreas; Body Weight; Brain; Brain Stem; Brainstem; Brown Fat; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Central Nervous System; Characteristics; Chemotherapy-Hormones/Steroids; DMN; Data; Diabetes Mellitus; Dorsal Motor Nucleus of the Vagus; Eating; Eating Disorders; Encephalon; Encephalons; Endocrine Gland Secretion; Energy Expenditure; Energy Metabolism; Food Intake; Grant; Health; Hepatic; Hibernating Gland; Hormone Receptor; Hormones; Human; Human, General; Hyperglycemia; Hyperinsulinemia; Hyperinsulinism; Hyperphagia; Hypothalamic structure; Hypothalamus; Incidence; Intake; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Knockout Mice; Lead; Leptin; Liver; MC4 Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Melanocortin 4 Receptor; Metabolic; Mice; Mice, Knock-out; Mice, Knockout; Microinjections; Motor Cell; Motor Neurons; Murine; Mus; Nerve; Nerve Cells; Nerve Unit; Nervosas, Anorexia; Nervous; Nervous System, Brain; Nervous System, CNS; Nesidioblasts; Neural Cell; Neuraxis; Neurocyte; Neurons; Nucleus; Null Mouse; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Overeating; Pancreas, Endocrine; Pancreatic Islets; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pars endocrina pancreatis; Pathway interactions; Pb element; Population; Receptor, Melanocortin, Type 4; Regulation; Signal Transduction; Signal Transduction Systems; Signaling; Site; Societies; Spinal Cord; Structure of paraventricular nucleus; Syndrome; System; System, LOINC Axis 4; Testing; Therapeutic Hormone; adiposity; base; beta cell development; biological signal transduction; blood glucose regulation; body system, hepatic; cholinergic; cholinergic neuron; combat; corpulence; corpulency; corpulentia; design; designing; diabetes; diabetic; dorsal motor nucleus; endocrine pancreas; endocrine pancreas development; feeding; ghrelin; glucose RA; glucose control; glucose homeostasis; glucose production; glucose rate of appearance; glucose regulation; heavy metal Pb; heavy metal lead; hyperglycemic; hypothalamic; improved; insulin secretion; islet development; islet progenitor; melanocortin receptor; motoneuron; mouse model; neural; neuronal; ob/ob mouse; obese; obese people; obese person; obese population; organ system, hepatic; paraventricular nucleus; pathway; polyphagia; receptor expression; recombinase; relating to nervous system; restoration; transcription factor",Leptin Action and Central Melanocortin Systems,,53301,ZRG1,Special Emphasis Panel,S1,13,98440,
8013473,R37,GM,3,,07/01/2009,06/30/2011,,3R37GM026916-31S2,,NIGMS:38068;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EAST LANSING,UNITED STATES,BIOCHEMISTRY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"FERGUSON-MILLER, SHELAGH M;",1891884;,3R37GM026916,07/01/1979,06/30/2011,"Aging; Algae, Blue-Green; Biological Models; Blue-Green Bacteria; Cloning; Collaborations; Coupling; Crystallization; Crystallographies; Crystallography; Cyanobacterium; Cyanophyceae; Cyanophyta; Cytochrome Oxidase; Cytochrome-c Oxidase (Complex IV); Deuterium; Electron Transport; Electron Transport Complex IV; Electrons; Engineering; Engineerings; Enzymes; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Freezing; Genes; Grant; H(+) Pump; H+ element; H2 isotope; Hydrogen Ions; Kinetic; Kinetics; Knowledge; Lead; Ligands; Measures; Methods; Model System; Modeling; Models, Biologic; Movement; Mutagenesis, Site-Directed; Nature; Negative Beta Particle; Negatrons; Obesity; Oxidases; Oxidation-Reduction; Pb element; Plasmids; Probability; Property; Property, LOINC Axis 2; Proton Pump; Protons; Redox; Resolution; Rhodobacter sphaeroides; Rhodobacter spheroides; Rhodopseudomonas sphaeroides; Rhodopseudomonas spheroides; Senescence; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Structure; Synechocystis; Targeted DNA Modification; Targeted Modification; Testing; Weight maintenance regimen; adiposity; base; body movement; corpulence; corpulency; corpulentia; cytochrome c oxidase; electron transfer; heavy metal Pb; heavy metal lead; heme a; mutant; obese; obese people; obese person; obese population; oxidation reduction reaction; respiratory; senescent; tool; weight control",ENERGY TRANSDUCTION IN CYTOCHROME OXIDASE,,26916,NSS,,S2,31,38068,
8011921,R37,GM,3,Y,02/05/2010,07/30/2010,,3R37GM033063-27S1,,NIGMS:102023;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,OTHER BASIC SCIENCES,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"ESKO, JEFFREY D;",1867343;,3R37GM033063,02/05/2010,07/30/2010,"2-Acetamido-2-Deoxy-D-Glucose; 2-Acetamido-2-Deoxyglucose; Abbreviations; Acetylglucosamine; Address; Affect; Alleles; Allelomorphs; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; BACs (Chromosomes); Bacterial Artificial Chromosomes; Binding; Binding (Molecular Function); Biochemical; Body Tissues; Brain; CHO Cells; CMV; Cell Transformation, Neoplastic; Cells; Chinese Hamster; Chinese Hamster Ovary Cell; Chondrodysplasia, Hereditary Deforming; Chondroitin Sulfates; Chondroitin, hydrogen sulfate; Cloning; Complementary DNA; Connective Tissue; Cytomegalovirus; D-Glucose, 2-(acetylamino)-2-deoxy-; DNA Synthesis Factor; DNA, Complementary; Deacetylase; Diaphyseal Aclasis; EC 2; EC 2.5.1.18; EC 2.8.2; ECGF; Encephalon; Encephalons; Endothelial Cell Growth Factor; Enzymes; Exostoses, Familial; Exostoses, Multiple; Exostoses, Multiple Cartilaginous; FGF; FGF-2; FGF2; Family; Fibroblast Growth Factor; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Fibroblast Growth Regulatory Factor; GAG; GAG Gene; GFP; GST; Gene Copy Number; Gene Dosage; Gene Targeting; Genes; Genes, Regulator; Genetic; Genital System, Female, Ovary; Glucuronic Acids; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione Transferase; Glycosaminoglycans; Goals; Green Fluorescent Proteins; Growth Disorders; HBGF; HBGF-2; HCMV; HSPG; Hamster, Chinese; Heme Transfer Protein; Heparan Sulfate; Heparan Sulfate Biosynthesis; Heparan Sulfate Proteoglycan; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Heparitin Sulfate; Hereditary Multiple Exostoses; Hexouronic Acids; Hexuronic Acids; Iduronic Acid; Immobilization; Individual; Intermediary Metabolism; Investigators; Isoenzymes; Isozymes; Lead; Ligandins; Ligands; METBL; Mammals, Mice; Metabolic Processes; Metabolism; Mice; Mice, Mutant Strains; Molecular Interaction; Mucopolysaccharides; Murine; Mus; Mutant Strains Mice; N acetylglucosamine; N-Acetyl-D-Glucosamine; Neoplastic Cell Transformation; Nervous System, Brain; Oligosaccharides; Organism-Level Process; Organismal Process; Osteochondromas, Multiple; Ovary; Pathway interactions; Pb element; Physiologic Processes; Physiological Processes; Plasmids; Process; Programs (PT); Programs [Publication Type]; Prostate Epithelial Cell Growth Factor; Prostatropin; Protein-Carbohydrate Interaction; Proteins; Proteoglycan; Proteoheparan Sulfate; RT-PCR; RTPCR; RX[{..}]glutathione R-transferase; Regulation; Regulator Genes; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; S-Hydroxyalkyl Glutathione Lyase; Salivary Gland Viruses; Screening procedure; Series; Specificity; Structure; Substrate Specificity; System; System, LOINC Axis 4; Targetings, Gene; Tissues; Transcriptional Regulatory Elements; Transferase; VEGFs; Vascular Endothelial Cell; Vascular Endothelial Growth Factors; Vegf; atheromatosis; atherosclerotic vascular disease; bFGF; cDNA; cytomegalovirus group; experiment; experimental research; experimental study; gene product; glutathione aralkyltransferase; glutathione aryltransferase; heavy metal Pb; heavy metal lead; his-PG; human cytomegalovirus; human disease; immobilization of body part; insight; interest; member; mouse mutant; mutant; neoplastic transformation; new approaches; novel approaches; novel strategies; novel strategy; orthopedic freezing; pathway; polymerization; progesterone 11-hemisuccinate-(2-iodohistamine); programs; regulatory gene; research study; reverse transcriptase PCR; screening; screenings; sulfation; sulfotransferase; trans acting element",GENETIC CONTROL OF PROTEOGLYCAN METABOLISM,,33063,NSS,,S1,27,102023,
7999958,R37,GM,3,Y,01/25/2010,12/31/2010,,3R37GM037432-24S1,,NIGMS:177500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLOTTESVILLE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"GUMBINER, BARRY M.;",1897703;,3R37GM037432,01/25/2010,12/31/2010,"APC; APC Protein; Accounting; Adenomatous Polyposis Coli Protein; Adhesions; Adhesives; Affect; Assay; Axin protein; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Body Tissues; CAM 120/80; Cadherin-1; Cadherins; Cancers; Cell Adhesion; Cell Communication; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Fraction; Cell Interaction; Cell Line, Tumor; Cell Nucleus; Cell Signaling; Cell membrane; Cell-Cell Adhesion; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Cellular Expansion; Cellular Growth; Closure by Ligation; Complex; Contact Inhibition; Cytoplasmic Membrane; Development; Docking; E-Cadherin; EC 2.7; Embryo; Embryonic; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Event; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genetic Alteration; Genetic Change; Genetic defect; Human; Human, General; Import, Nuclear; Importin-alpha; In Vitro; Intracellular Communication and Signaling; Investigators; Kinases; Ligation; Liver Cell Adhesion Molecules; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal; Molecular Interaction; Morphogenesis; Mutation; NLS Receptor; NLS-Binding Protein; NLSBP; Neural Crest; Nuclear; Nuclear Import; Nuclear Localization Sequence Receptor; Nuclear Localization Signal-Binding Protein; Nuclear Pore; Nucleus; Particulate; Pathway interactions; Phosphorylation; Phosphorylation Site; Phosphotransferases; Plasma Membrane; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Testing; Tissues; Transphosphorylases; Tumor Cell; Tumor Cell Line; Tumor Suppressor Proteins; Uvomorulin; Xenopus; alpha Karyopherins; biological signal transduction; cell growth; experiment; experimental research; experimental study; gene product; genome mutation; in vitro Assay; insight; liver cell adhesion molecule; malignancy; neoplasm/cancer; neoplastic cell; novel; pathway; plasmalemma; programs; protein complex; research study; response; social role; tumor growth; tumor suppressor",CATENIN AND CADHERIN SIGNALING IN DEVELOPMENT AND CANCER,,37432,NSS,,S1,24,177500,
7999977,R37,GM,3,Y,01/07/2010,12/31/2010,,3R37GM043880-20S1,,NIGMS:15677;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,RICHMOND,UNITED STATES,BIOCHEMISTRY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"SPIEGEL, SARAH ;",1872580;,3R37GM043880,01/07/2010,12/31/2010,"Anabolism; Apoptosis; Apoptosis Pathway; Attenuated; Autocrine Systems; Bioavailability; Biologic Availability; Biological Availability; Biological Function; Biological Process; Biology; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Death, Programmed; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Signaling; Cell surface; Cells; Cellular Expansion; Cellular Growth; Cellular Migration; Ceramide (lipids); Ceramides; Cloning; Elements; Endoplasmic Reticulum; Equilibrium; Ergastoplasm; Event; Family; INFLM; Inflammation; Intermediary Metabolism; Intracellular Communication and Signaling; Knowledge; Ligands; Lipids; METBL; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic Processes; Metabolism; Molecular; Motility; Motility, Cellular; Nucleus; Phosphatases; Phosphates; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiologic Availability; Physiological; Play; Receptor Protein; Regulation; Research; Role; S1P phosphatase; SPH-1-lyase; SPP1 enzyme; Signal Transduction; Signal Transduction Systems; Signaling; Sphingolipids; Stress; allergic response; angiogenesis; autocrine; balance; balance function; bioavailability of drug; biological signal transduction; biosynthesis; cardiovascular disorder; cell growth; cell motility; cellular targeting; inorganic phosphate; lipid mediator; malignancy; mitochondrial autophagy; neoplasm/cancer; prototype; receptor; social role; sphingosine 1-phosphate; sphingosine 1-phosphate lyase (aldolase); sphingosine kinase; sphingosine-1-phosphate lyase; sphingosine-1-phosphate phosphatase",Roles of sphingosine-1 phosphate phosphohydrolase,,43880,NSS,,S1,20,15677,
8009629,R42,DK,3,Y,02/01/2010,08/31/2010,PA-06-121,3R42DK063882-06S1,,NIDDK:37500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,,09,140243572,US,TX,77054,"PLX PHARMA, INC.","LICHTENBERGER, LENARD M;",1893303;,3R42DK063882,02/01/2010,08/31/2010,"2-(Acetyloxy)benzoic Acid; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; Acetylsalicylic Acid; Adverse Experience; Adverse effects; Adverse event; Age; Age-Years; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; American; Analgesics, Anti Inflammatory; Animals; Anti Inflammatory Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Applications Grants; Arthritis; Arthritis, Degenerative; Aspergum; Aspirin; Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; Bextra; Bioavailability; Bioequivalence; Biologic Availability; Biological Availability; Biological Models; Bleeding; Businesses; COX-2; COX2; COX2 inhibitor; Cahill May Roberts brand of rofecoxib; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cessation of life; Characteristics; Chemicals; Choline Glycerophospholipids; Choline Phosphoglycerides; Chronic; Clinical; Clinical Data; Clinical Equivalency; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Complex; Coxibs; Critiques; Cyclooxygenase 2 Inhibitors; Data; Death; Degenerative polyarthritis; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Dose; Drug Formulations; Drug Kinetics; Drug user; Drugs; Economics; Ecotrin; Editorial Comment; Editorial Comment (PT); Empirin; Entericin; Extren; Family; Formulation; Formulations, Drug; Funding; Gastrointestinal Injury; Generic Equivalency; Goals; Grant; Grant Proposals; Grants, Applications; Guidelines; HOSP; Health; Hemorrhage; Heumann brand of celecoxib; Hospitalization; Human; Human, General; INFLM; Ibuprofen; Individual; Inflammation; Investigation; Investigators; Kaschin-Beck disease; Label; Laboratories; Lead; Learning; Lecithin; Left; Link; Lipids; MSD brand of rofecoxib; Mack brand of celecoxib; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manufacturer; Manufacturer Name; Marketing; Measurin; Medication; Merck Frosst brand of rofecoxib; Merck Sharp & Dhome brand of rofecoxib; Merck brand of rofecoxib; Methods; Minor; Model System; Models, Biologic; Motrin; Mucosa; Mucosal Tissue; Mucous Membrane; NIH; NSAIDs; National Institutes of Health; National Institutes of Health (U.S.); Non-Steroidal Anti-Inflammatory Agents; Nonsteroidal Anti-Inflammatory Agents; Nonsteroidal Antiinflammatory Drug; Odontalgia; Oils; Organ System, Cardiovascular; Osteoarthritis; Osteoarthrosis; Osteoarthrosis Deformans; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Pain; Painful; Parke Davis brand of celecoxib; Patients; Pb element; Pfizer brand of celecoxib; Pfizer brand of valdecoxib; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacia Spain brand of celecoxib; Pharmacia brand of celecoxib; Pharmacia brand of valdecoxib; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Phase; Phase 2 Clinical Trials; Phase II Clinical Trials; Phosphatidylcholines; Physiologic Availability; Plague; Population; Position; Positioning Attribute; Prevention; Prevention Measures; Primary Senile Degenerative Dementia; Product Approvals; Programs (PT); Programs [Publication Type]; Prophylactic treatment; Prophylaxis; Published Comment; Rat; Rattus; Regulatory Pathway; Research; Research Contracts; Research Personnel; Researchers; Rodent; Rodent Model; Rodentia; Rodentias; Rofecoxib; STTR; Safety; Searle brand of celecoxib; Series; Small Business Technology Transfer Research; Source; Surface; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Therapeutic Equivalency; Time; TimeLine; Toothache; Toxic effect; Toxicities; Treatment Efficacy; Treatment Side Effects; ULCN; Ulcer; Ulceration; United States National Institutes of Health; Vascular, Heart; Viewpoint; Viewpoint (PT); Vioxx; Vioxx Dolor; Withdrawal; Work; Yersinia pestis disease; alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid; arthritic; base; bioavailability of drug; blood loss; cancer prevention; celebrex; celecoxib; chemical association; circulatory system; clinical investigation; commercialization; degenerative joint disease; dementia of the Alzheimer type; dental pain; dentalgia; drug bioequivalence; drug bioequivalent; drug detection; drug efficacy; drug market; drug testing; drug/agent; experiment; experimental research; experimental study; gastrointestinal; hCOX-2; heavy metal Pb; heavy metal lead; human subject; hypertrophic arthritis; improved; inhibitor; inhibitor/antagonist; irritation; meetings; member; nonsteroidal anti-inflammatory drugs; novel; osteoarthritic; p-Isobutylhydratropic Acid; phase 1 study; phase 2 study; phase 2 trial; phase 3 study; phase II trial; pre-clinical; preclinical; preclinical study; prevent; preventing; primary degenerative dementia; programs; protocol, phase II; pyogenic sterile arthritis, pyoderma gangrenosum and acne; research study; response; senile dementia of the Alzheimer type; side effect; soy; study, phase II; therapeutic efficacy; therapeutically effective; therapy adverse effect; treatment adverse effect",Gastrointestinal safety and therapeutics of oil-based Phosphatidylcholine-NSAIDS,,63882,ZRG1,Special Emphasis Panel,S1,6,37500,
8005176,R43,GM,3,Y,01/29/2010,02/28/2011,PA-08-050,3R43GM087807-01A1S1,,NIGMS:45000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,TUCSON,UNITED STATES,,08,013685265,US,AZ,857479159,"LUCEOME BIOTECHNOLOGIES, LLC","ZUTSHI, REENA ;",7536472;,3R43GM087807,01/29/2010,02/28/2011,"(-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-4-morpholin] propoxy]; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-; ATP-protein phosphotransferase; Active Sites; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Arizona; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Bioluminescence; Boxing; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; Chemicals; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Collection; Cyclic AMP-Dependent Protein Kinases; Data; Development; Diabetes Mellitus; Dimerization; Disease; Disorder; Drug Industry; Drugs; EC 2.7; Environment; Enzymes; FRET; Flavopirodol/HMR-1275; Fluorescence; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Freedom; Gefitinib; Gene Family; Generations; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genome, Human; Gleevec; Glivec; Goals; High Throughput Assay; Hour; Human; Human Biology; Human Genome; Human, General; Image; Imatinib; Immunologic, Luciferase; In Vitro; Industry, Pharmaceutic; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Iressa; Kinases; Label; Lead; Legal patent; Liberty; Libraries; Licensing; Ligand Binding Protein; Ligands; Light; Literature; Luciferases; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Marketing; Measurement; Mediation; Medication; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Interaction; Monitor; Mutation; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; Negotiating; Negotiation; PKA; PKC-412; PKC412; Patents; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Industry; Pharmaceutical Preparations; Phase; Phosphotransferases; Photoradiation; Physiologic; Physiological; Production; Protein Dimerization; Protein Kinase; Protein Kinase A; Proteins; Radioactive; Regulation; Reporter; Role; SBIR; SBIRS (R43/44); Safety; Screening procedure; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Sites, Active; Small Business Innovation Research; Small Business Innovation Research Grant; Source; Specificity; Staurosporine; Sutent; System; System, LOINC Axis 4; Techniques; Technology; Therapeutic Agents; Transphosphorylases; Universities; Washington; base; biological signal transduction; cAMP-Dependent Protein Kinases; clinical investigation; commercialization; diabetes; disease/disorder; drug discovery; drug/agent; flavopiridol; gene product; genome mutation; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; high throughput screening; hydroxyalkyl protein kinase; hydroxyl group; imaging; in vitro Assay; inhibitor; inhibitor/antagonist; interest; interventional strategy; kinase inhibitor; luciferin; luminescence; malignancy; neoplasm/cancer; novel; phosphorylase b kinase kinase; protein expression; public health relevance; scaffold; scaffolding; screening; screenings; small molecule; social role; tool",Rapid Kinase Profiling with Luminescent Reporters," Kinases constitute 1.7% of the genome and are implicated in various diseases, from cancer to diabetes. Assessment of selectivity of drugs against kinases is critical to evaluate their physiological safety. The purpose of our application is to develop a method to identify selective drugs by profiling them against a kinase panel.",87807,ZRG1,Special Emphasis Panel,A1S1,1,45000,
8010783,R44,DK,3,Y,01/20/2010,06/30/2010,PA-06-120,3R44DK065322-04S1,,NIDDK:96281;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WOBURN,UNITED STATES,,07,161843057,US,MA,01801,"ORGANIX, INC.","SARD, HOWARD P;",1971983;,3R44DK065322,01/20/2010,06/30/2010,"(3-(2-dimethylamino)ethyl)indol-4-ol; (5-HT)2B Receptors; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate; 5-HT(2C) Receptor; 5-HT-2A Gene; 5-HT2A; 5-HT2B Receptor; 5-HT2C Receptor; 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene; 5-Hydroxytryptamine 2B Receptor; 5-Hydroxytryptamine Receptor 2A Gene; 5-Hydroxytryptamine Type 2C Receptors; Acute; Adverse effects; Affect; Agonist; American; Animal Model; Animal Models and Related Studies; Anorectic Drug; Anorectic agent; Anorectics; Anorexiant; Anorexic Drugs; Anorexient Agent; Anorexient Drug; Anorexigenic Drugs; Anti-Obesity Agents; Anti-Obesity Drugs; Antiobesity Agents; Antiobesity Drugs; Appetite; Appetite Depressants; Appetite Suppressants; Appetite-Depressing Drugs; Appetite-Suppressant Drugs; Award; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (S)-; Bioavailability; Biodistribution; Biologic Availability; Biological; Biological Availability; Cats; Cell Nucleus; Chronic; Clinical; Desire for food; Development; Dexfenfluramine; Disease; Disorder; Domestic Cats; Drug Kinetics; Drug Therapy; Drugs; Epidemic; Evaluation; FDA approved; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fenfluramine; Gastrointestinal Tract, Pancreas; Goals; Grant; HTR2; HTR2 Gene; HTR2A; HTR2A gene; Health; Heart Valve Diseases; Hoffmann-La Roche brand of orlistat; In Vitro; Indoles; Isoforms; L-Leucine, N-formyl-, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester, (2S-(2alpha(R*),3beta))-; Lead; Levarterenol; Levonorepinephrine; Licensing; Lipase; Mammals, Cats; Mammals, Mice; Marketing; Medication; Meridia; Mice; Modification; Molecular; Murine; Mus; Noradrenaline; Norepinephrine; Nucleus; Obesity; Pancreas; Pancreatic; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Pharmacotherapy; Phase; Phosphates; Physiologic Availability; Preparation; Program Development; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Receptor Protein; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Redux; Research; Research Resources; Resources; Roche brand of orlistat; SBIR; SBIRS (R43/44); SSRI; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Serotonin 2B Receptor; Serotonin 2C Receptor; Serotonin 5-HT-2 Receptor Gene; Site; Small Business Innovation Research; Small Business Innovation Research Grant; Societies; Staging; Structure; Structure-Activity Relationship; THLP; Testing; Time; Toxic effect; Toxicities; Treatment Side Effects; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triolean Hydrolase; United States; Valvular Heart Diseases; Valvular Heart Disorder; Weight; Withdrawal; Work; Xenical; adiposity; analog; anorexic agent; base; bioavailability of drug; cardiac valve disease; cardiac valve disorder; cardiac valvular disease; chemical structure function; corpulence; corpulency; corpulentia; design; designing; disease/disorder; drug candidate; drug/agent; feeding; health economics; heart valve disorder; heavy metal Pb; heavy metal lead; improved; in vivo; inhibitor; inhibitor/antagonist; inorganic phosphate; model organism; novel; obese; obese people; obese person; obese population; obesity treatment; orlistat; programs; psilocin; receptor; receptor binding; serotonin reuptake inhibitor; sibutramine; side effect; structure function relationship; tetrahydrolipstatin; therapy adverse effect; treatment adverse effect; tributyrase",Indole Analogs as Novel Appetite Suppressants,,65322,ZRG1,Special Emphasis Panel,S1,4,96281,
7991664,R44,HD,3,Y,12/30/2009,12/29/2010,PA-06-120,3R44HD039566-03S1,,NICHD:370875;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEWARK,UNITED STATES,,10,193548695,US,NJ,07103,"UROVALVE, INC.","HOMAN, HARVEY D;",8480145;,3R44HD039566,12/30/2009,12/29/2010,"Abscission; Acute; Adverse Experience; Adverse event; Awareness of self; Bladder; Bladder Calculi; Bladder Stones; Boston; Care Givers; Caregivers; Caring; Case Report Form; CaseReportForm; Cathetergram; Catheterization; Catheters; Characteristics; Chronic; City of Boston; Clinic; Clinical; Clinical Research; Clinical Study; Collaborations; Consent Documents; Consent Forms; Contracting Opportunities; Contracts; Cross-Over Studies; Cross-Over Trials; Crossover Studies; Crossover Trials; Cystoliths; Data; Dependence; Development; Development and Research; Devices; Documentation; Effectiveness; Environment; Ethics Committees, Research; Excision; Exposure to; Extirpation; FDA approved; Feasibility Studies; Freedom; Funding; Genital System, Male, Prostate; HTRPY; Health; Health Benefit; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare Systems; Healthcare worker; Home; Home environment; Human; Human Prostate; Human Prostate Gland; Human, General; Hypertrophy; IRBs; Individual; Informed Consent; Informed Consent Documents; Informed Consent Forms; Institutional Review Boards; Kidney Diseases; Laboratories; Lead; Liberty; Life; MS (Multiple Sclerosis); Man (Taxonomy); Man, Modern; Manufacturer; Manufacturer Name; Mechanics; Medical; Methods; Morbidity; Morbidity - disease rate; Multiple Sclerosis; Myelopathy, Traumatic; Nephropathy; Nervous System Diseases; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Operation; Operative Procedures; Operative Surgical Procedures; Patient Care; Patient Care Delivery; Patients; Pattern; Pb element; Performance; Personal awareness; Phase; Physicians; Position; Positioning Attribute; Procedures; Process; Prostate; Prostate Gland; Prostatic Gland; Protocol; Protocols documentation; QOL; Qualifying; Quality of life; R & D; R&D; Reliance; Removal; Renal Disease; Reporting; Research Ethics Committees; Risk; SBIR; SBIRS (R43/44); Safety; Sclerosis, Disseminated; Self Perception; Self image; Self view; Small Business Innovation Research; Small Business Innovation Research Grant; Solutions; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Staging; Sterilization; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Systems, Health Care; Technology; Testing; Time; Trauma; UTI; Urethra; Urinary Retention; Urinary System, Bladder; Urinary tract; Urinary tract infection; Urinary tract infectious disease; Urologist; Validation; Vesical Calculi; Veterans; Writing; alternative treatment; compare effectiveness; cost; cost effectiveness; design; designing; experience; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; insular sclerosis; kidney disorder; male; medical personnel; meetings; men; men's; migration; nervous system disorder; neurological disease; prototype; renal disorder; research and development; resection; self awareness; self knowledge; stability testing; surgery; tool; treatment provider; urethral; urinary bladder",Disposable Valved Intraurethral Catheter Feasibility,,39566,ZRG1,Special Emphasis Panel,S1,3,370875,
8015176,RL1,NS,3,,02/01/2010,06/30/2010,RM-06-008,3RL1NS062413-03S2,,NINDS:32932;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NOVATO,UNITED STATES,,06,786502351,US,CA,94945,BUCK INSTITUTE FOR AGE RESEARCH,"ELLERBY, LISA M.;",7742722;,3RL1NS062413,09/30/2007,01/31/2011,"Acetylation; Address; Affect; Age; Aging; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Model; Animal Models and Related Studies; Area; Autoregulation; Biology of Aging; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Causality; Coupled; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Discipline; Disease; Disease Progression; Disease model; Disorder; Drosophila; Drosophila genus; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; Enzymes; Etiology; Family member; Figs; Figs - dietary; Fruit Fly, Drosophila; Functional disorder; Genes; Goals; HDAC; HDAC Agent; HDAC Proteins; Histone Acetylation; Histone Deacetylase; Histone Deacetylase Inhibitor; Homeostasis; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Individual; Interdisciplinary Research; Interdisciplinary Study; Intervention; Intervention Strategies; Investigators; Lead; Length of Life; Lewy Body Parkinson Disease; Longevity; MODY; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Maturity-Onset Diabetes Mellitus; Modeling; Multidisciplinary Collaboration; Multidisciplinary Research; NIDDM; Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Organ System, Cardiovascular; Organism; Osteoporosis; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pb element; Physiological Homeostasis; Physiopathology; Play; Poly Q; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Research Personnel; Researchers; Risk Factors; Role; Senescence; Series; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirtuins; Study, Interdisciplinary; System; System, LOINC Axis 4; T2D; T2DM; Testing; Therapeutic Intervention; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Type 2 diabetes; Type II diabetes; Vascular, Heart; Yeasts; adult onset diabetes; age dependent; age related; cancer type; circulatory system; dementia of the Alzheimer type; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; disorder model; fruit fly; gene product; heavy metal Pb; heavy metal lead; interdisciplinary approach; intervention therapy; interventional strategy; ketosis resistant diabetes; life span; lifespan; living system; malignancy; maturity onset diabetes; model organism; mutant; neoplasm/cancer; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; pathophysiology; poly(glutamine); polyQ; polyglutamine; prevent; preventing; primary degenerative dementia; programs; senescent; senile dementia of the Alzheimer type; social role; therapeutic target",HDACs in Neurodegeneration and Aging,,62413,ZRR1,Special Emphasis Panel,S2,3,32932,
8015721,T32,DK,3,,12/01/2009,06/30/2010,PA-06-468,3T32DK007202-34S2,,NIDDK:50317;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"CARETHERS, JOHN M;",1881340;,3T32DK007202,07/01/1976,06/30/2012,Gastroenterology; Grant; Training,Gastroenterology Training Grant,,7202,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,S2,34,50317,
8015752,T42,OH,3,,07/01/2009,06/30/2010,PAR-06-485,3T42OH009229-03S2,,NIOSH:;,2010,NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH,,AURORA,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"NEWMAN, LEE S;",1865596;,3T42OH009229,07/01/2007,06/30/2010,,Mountain and Plains Education and Research Center,,9229,ZOH1,Special Emphasis Panel,S2,3,50536,
8009906,U01,DK,3,,01/01/2010,12/31/2010,DK-05-504,3U01DK057177-11S2,,NIDDK:120766;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"FOREYT, JOHN P.;",1862368;,3U01DK057177,09/30/1999,07/31/2013,"21+ years old; Active Follow-up; Adherence; Adherence (attribute); Adult; Affect; Angioplasty; Aortocoronary Bypass; Apoplexy; Applications Grants; Arm; BMI percentile; BMI z-score; Body Weight decreased; Body mass index; Bypass; Caloric Intake; Cardiac Failure Congestive; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Carotid Endarterectomy; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Community Health Centers; Congestive Heart Failure; Control Groups; Coronary Artery Bypass; Coronary Artery Bypass Grafting; Coronary Artery Bypass Surgery; Country; Data; Death; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Education; Educational aspects; Effectiveness of Interventions; Effects, Longterm; Endarterectomy, Carotid; Energy Intake; Epidemic; Event; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Funding; Future; Goals; Grant; Grant Proposals; Grants, Applications; HOSP; Health; Heart Decompensation; Heart Failure, Congestive; Hospitalization; Human, Adult; Incidence; Indirect Costs; Intervention; Intervention Strategies; Long-Term Effects; Longitudinal Studies; MODY; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Metabolic; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Myocardial Infarct; Myocardial Infarction; NIDDM; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ System, Cardiovascular; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Over weight; Overweight; Participant; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Persons; Physical activity; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Quetelet index; Randomized; Randomized Clinical Trials; Recruitment Activity; Research Design; Risk Factors; Sampling; Satellite Centers; Stroke; Study Type; T2D; T2DM; Telephone Interviews; Testing; Time; Trials, Randomized Clinical; Type 2 diabetes; Type II diabetes; United States; United States National Institutes of Health; Upper arm; Vascular Accident, Brain; Vascular, Heart; Visit; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; adiposity; adult human (21+); adult onset diabetes; base; body weight gain; body weight increase; body weight loss; brain attack; caloric dietary content; cardiac infarct; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cerebral vascular accident; circulatory system; clinical research site; clinical site; cohort; coronary angioplasty; coronary attack; coronary bypass; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cost effectiveness; design; designing; diabetes; disease/disorder; effect of intervention; follow-up; hazard; heart attack; heart infarct; heart infarction; intervention design; intervention effect; intervention program; interventional strategy; intraluminal angioplasty; ketosis resistant diabetes; life style intervention; lifestyle intervention; long-term study; maturity onset diabetes; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; obese; obese people; obese person; obese population; obesity risk; peripheral blood vessel disorder; primary outcome; programs; public health medicine (field); randomisation; randomization; randomly assigned; recruit; secondary outcome; stroke; study design; therapy design; treatment design; volunteer; weight loss intervention; wt gain; wt-loss",Look AHEAD: Action for Health in Diabetes,,57177,ZDK1,Special Emphasis Panel,S2,11,120766,
7815887,U01,DK,3,Y,01/14/2010,06/30/2010,OD-09-058,3U01DK060401-08S1,,NIDDK:51910;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,SURGERY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"ALBO, MICHAEL ;",6409993;,3U01DK060401,01/14/2010,06/30/2010,"Arm; Autologous; Award; California; Characteristics; Client satisfaction; Clinical; Data; Data Coordinating Center; Data Coordination Center; Dysfunction; Employment Opportunities; Ensure; Esapent; Esprit; FLR; Failure (biologic function); Fascia; Feasibility Studies; Functional disorder; Funding; Funding Mechanisms; Grant; Incontinence; Incontinence when straining; Injury; Investigators; Morbidity; Morbidity - disease rate; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Operation; Operative Procedures; Operative Surgical Procedures; Pain; Painful; Patient Satisfaction; Patient Self-Report; Patients; Physiopathology; Post-Operative; Postoperative; Postoperative Period; Procedures; Procidentia; Prolapse; Protocol; Protocols documentation; Ptosis; QOL; Quality of life; Randomized; Randomized Clinical Trials; Recovery; Recurrence; Recurrent; Research; Research Personnel; Researchers; Risk Factors; SIS; Self-Report; Sister; Speed; Speed (motion); Stress; Stress Incontinence; Stress Urinary Incontinence; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Time; Treatment outcome; Trials, Randomized Clinical; UTI; United States National Institutes of Health; Universities; Upper arm; Urge Incontinence; Urinary Incontinence; Urinary Incontinence, Stress; Urinary tract infection; Urinary tract infectious disease; Urodynamic; Urodynamics; Woman; base; comparative effectiveness; cost; economic impact; effectiveness trial; experience; failure; health science research; multidisciplinary; parent grant; pathophysiology; public health relevance; randomisation; randomization; randomly assigned; response; secondary outcome; success; surgery; treatment center",UCSD INCONTINENCE TREATMENT CENTER,,60401,ZDK1,Special Emphasis Panel,S1,8,51910,
8012042,U01,DK,3,Y,01/25/2010,12/31/2010,DK-08-505,3U01DK061713-08S1,,NIDDK:149904;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"DIEHL, ANNA MAE ELIZABETH;",1872923;,3U01DK061713,05/01/2002,12/31/2010,"0-11 years old; 21+ years old; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; Active Follow-up; Address; Adult; Affect; American; Ancillary Study; Attention; Blood Serum; Body Tissues; Burn injury; Burns; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Childhood; Children (0-21); Chronic; Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Database; Clinical Trials, Therapy; Clinical Trials, Unspecified; Collection; Control Groups; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Department of Health and Human Services; Department of Health and Human Services (U.S.); Development; Diabetes Mellitus; Diagnosis; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disease Frequency Surveys; Disease Progression; Disorder; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Elements; Enrollment; Erinaceidae; Fatty Liver; Feasibility Studies; Fibrosis; Funding; GWAS; Genetic; Goals; HHS; HOSP; Health; Hedgehogs; Hepatic Disorder; Histology; Hospitals; Human, Adult; Human, Child; Imidodicarbonimidic diamide, N,N-dimethyl-; Incidence; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Length; Liver; Liver Steatosis; Liver diseases; Longitudinal Studies; Metformin; Methods; Modification; NAFLD; NASH; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Non-alcoholic steatohepatitis; North America; Organ System, Cardiovascular; PBO; Pathogenesis; Pathway interactions; Patients; Performance; Phenotype; Pilot Projects; Pioglitazone; Placebos; Prevention; Proteomics; Protocol; Protocols documentation; Publications; Randomized; Randomized Clinical Trials; Reporting; Research; Risk; Risk Factors; Sampling; Scientific Publication; Serum; Severity of illness; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Staging; Systems Biology; Therapeutic; Therapeutic Intervention; Therapeutic Studies; Therapeutic Trials; Therapy Clinical Trials; Therapy Research; Tissue Sample; Tissues; Trials, Randomized Clinical; United States; United States Department of Health and Human Services; United States Dept. of Health and Human Services; United States National Institutes of Health; Universities; VIT D; Vascular, Heart; Vitamin D; Vitamin E; Work; adult human (21+); base; biological signal transduction; biomarker; biopsy of liver; body system, hepatic; cardiovascular disorder; children; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical material; cytokine; data repository; diabetes; disease natural history; disease severity; disease/disorder; effective therapy; enroll; epithelial to mesenchymal transition; follow-up; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hepatic steatosis; hepatopathy; insulin sensitizer; insulin sensitizing drugs; interest; intervention therapy; interventional strategy; liver biopsy; liver disorder; long-term study; measurement of metabolism; meetings; member; metabolomics; natural history of disease; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; novel; organ system, hepatic; pathway; pediatric; pilot study; prospective; public health relevance; randomisation; randomization; randomly assigned; relational database; response; sham therapy; sober; sobriety; success; therapeutic target; tool; whole genome association studies; whole genome association study; youngster",NASH Clinical Research Network,"Public Health Relevance: (provided by the applicant): NAFLD and NASH are important health problems and their incidence is expected to increase. During the initial funding period, the CRN has made important contributions to the field of NAFLD and NASH, however there remain numerous unanswered questions. During the next funding period, the CRN will continue to investigate risk factors, clinical aspects, natural history and optimal treatment for NASH and associated conditions ",61713,ZDK1,Special Emphasis Panel,S1,8,149904,
8012130,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-505,3U01DK061718-08S1,,NIDDK:149038;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,050220722,US,MO,63103,SAINT LOUIS UNIVERSITY,"NEUSCHWANDER-TETRI, BRENT A;",1881134;,3U01DK061718,02/01/2010,01/31/2011,"0-11 years old; 21+ years old; 4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin; Active Follow-up; Address; Adult; Affect; Age; American; Aminotransferases; Ancillary Study; Attention; Biochemical; Biopsy; Blood Serum; Body Composition; Body Tissues; Burn injury; Burns; Carcinoma of the Liver Cells; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Child; Child Youth; Childhood; Children (0-21); Chronic; Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Consumption; Control Groups; Data; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Databank, Electronic; Databanks; Database, Electronic; Databases; Department of Health and Human Services; Department of Health and Human Services (U.S.); Development; Diabetes Mellitus; Diagnosis; Disease; Disease Progression; Disorder; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; EC 2.6.1; Elements; Endotoxemia; Enrollment; Enteral; Enteric; Fatty Liver; Feasibility Studies; Fibrosis; Funding; GWAS; Gastrointestinal Tract, Small Intestine; Genetic; Goals; HCC; HHS; Health; Hepatic Disorder; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Histology; Human, Adult; Human, Child; INFLM; Image; Incidence; Inflammation; Injury; Insulin Resistance; Intestinal; Intestines; Intestines, Small; Investigators; Length; Lipid Trafficking; Lipids; Liver; Liver Steatosis; Liver diseases; Longitudinal Studies; Methods; Methods and Techniques; Methods, Other; Modification; NAFLD; NASH; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Non-alcoholic steatohepatitis; North America; Obesity; Organ System, Cardiovascular; Pathogenesis; Patients; Performance; Permeability; Phenotype; Pilot Projects; Prevention; Primary carcinoma of the liver cells; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proteomics; Protocol; Protocols documentation; Randomized; Randomized Clinical Trials; Recruitment Activity; Reporting; Research; Research Personnel; Researchers; Risk; Risk Factors; Role; Saints; Sampling; Secondary to; Serum; Severity of illness; Site; Small Intestines; Source; Specificity; Staging; Staining method; Stainings; Stains; Study Subject; Systems Biology; Techniques; Therapeutic Studies; Therapy Research; Tissues; Trans Fats; Transaminases; Trials, Randomized Clinical; United States; United States Department of Health and Human Services; United States Dept. of Health and Human Services; United States National Institutes of Health; Universities; Vascular, Heart; Vegetables; Work; adiposity; adult human (21+); base; biomarker; biopsy of liver; body system, hepatic; bowel; cardiovascular disorder; children; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical material; corpulence; corpulency; corpulentia; cytokine; data repository; diabetes; dietary vegetable; disease natural history; disease severity; disease/disorder; effective therapy; enroll; follow-up; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hepatic steatosis; hepatopathy; imaging; improved; insulin resistant; insulin sensitizer; insulin sensitizing drugs; interest; lipid transport; liver biopsy; liver disorder; long-term study; measurement of metabolism; meetings; metabolomics; natural history of disease; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; obese; obese people; obese person; obese population; organ system, hepatic; pediatric; pilot study; placebo controlled study; placebo controlled trial; programs; prospective; public health relevance; randomisation; randomization; randomly assigned; recruit; regenerative; relational database; rifaximin; small bowel; sober; sobriety; social role; success; tool; whole genome association studies; whole genome association study; youngster",The Saint Louis University Component of the NASH Clinical Research Network,,61718,ZDK1,Special Emphasis Panel,S1,8,149038,
8011881,U01,DK,3,Y,01/25/2010,12/31/2010,DK-08-505,3U01DK061728-09S1,,NIDDK:150000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SEATTLE,UNITED STATES,,07,076647908,US,WA,981012795,BENAROYA RESEARCH INST AT VIRGINIA MASON,"KOWDLEY, KRIS ;",2263793;,3U01DK061728,07/01/2002,12/31/2010,"0-11 years old; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-; 21+ years old; Accounting; Active Follow-up; Address; Adult; Affect; American; Ancillary Study; Area; Attention; Award; Blood Serum; Body Tissues; Burn injury; Burns; Cardiovascular Diseases; Child; Child Youth; Children (0-21); Chronic; Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials, Therapy; Curcumin; Data; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Databank, Electronic; Databanks; Database, Electronic; Databases; Department of Health and Human Services; Department of Health and Human Services (U.S.); Deposit; Deposition; Diabetes Mellitus; Diagnosis; Diet; Diferuloylmethane; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disease Progression; Disorder; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Elements; Enrollment; Expression Profiling; Expression Signature; Fatty Liver; Fe element; Feasibility Studies; Fenofibrate; Funding; GWAS; Gene Expression; Genetic; Genotype; Goals; HHS; Health; Hepatic; Hepatic Disorder; Hepatic Stellate Cell; Hepc, peptide; Histologic; Histologically; Human, Adult; Human, Child; Imidodicarbonimidic diamide, N,N-dimethyl-; Incidence; Iron; Ito Cell; Length; Life Style; Lifestyle; Liver; Liver Steatosis; Liver diseases; Longitudinal Studies; Medical center; Metformin; Methods; Modification; Molecular Fingerprinting; Molecular Profiling; NAFLD; NASH; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Non-alcoholic steatohepatitis; North America; Oxidative Stress; Pathogenesis; Patients; Pattern; Performance; Phenofibrate; Phenotype; Pilot Projects; Prevalence; Prevention; Procetofen; Procetofene; Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, 1-methylethyl ester; Protein Glycosylation; Proteomics; Protocol; Protocols documentation; Publications; Randomized; Randomized Clinical Trials; Reporting; Research; Research Resources; Resources; Risk; Risk Factors; Role; Sampling; Scientific Publication; Serum; Serum Proteins; Severities; Severity of illness; Staging; Therapeutic Studies; Therapeutic Trials; Therapy Clinical Trials; Therapy Research; Tissues; Trials, Randomized Clinical; Tricor; Turmeric Yellow; United States; United States Department of Health and Human Services; United States Dept. of Health and Human Services; United States National Institutes of Health; Virginia; Work; adult human (21+); base; biobank; biopsy of liver; body system, hepatic; cardiovascular disorder; children; clinical data repository; clinical data warehouse; clinical material; cytokine; data repository; diabetes; disease natural history; disease severity; disease/disorder; effective therapy; enroll; follow-up; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hepatic steatosis; hepatopathy; hepcidin; in vivo; iron metabolism; liver biopsy; liver disorder; long-term study; measurement of metabolism; meetings; metabolomics; molecuar profile; molecular signature; natural history of disease; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; organ system, hepatic; pilot study; public health relevance; randomisation; randomization; randomly assigned; relational database; sober; sobriety; social role; success; tool; whole genome association studies; whole genome association study; youngster",Clinical Research Network in Non-Alcoholic Steatohepatitis,"Public Health Relevance: (provided by the applicant): NAFLD and NASH are important health problems and their incidence is expected to increase. During the initial funding period, the CRN has made important contributions to the field of NAFLD and NASH, however there remain numerous unanswered questions. During the next funding period, the CRN will continue to investigate risk factors, clinical aspects, natural history and optimal treatment for NASH and associated conditions",61728,ZDK1,Special Emphasis Panel,S1,9,150000,
8012483,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-505,3U01DK061730-08S1,,NIDDK:74997;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"TONASCIA, JAMES A;",1974478;,3U01DK061730,02/01/2010,01/31/2011,"0-11 years old; 21+ years old; Active Follow-up; Address; Adult; Affect; American; Analysis, Data; Ancillary Study; Archives; Attention; Blood Sample; Blood Serum; Blood specimen; Burn injury; Burns; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Causality; Child; Child Youth; Children (0-21); Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Therapy; Clinical Trials, Unspecified; Code; Coding System; Collection; Control Groups; Data; Data Analyses; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Data Monitoring Committees; Data Reporting; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Progression; Disorder; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Elements; Enrollment; Etiology; FDA; Fatty Liver; Feasibility Studies; Food and Drug Administration; Food and Drug Administration (U.S.); Funding; Genetic; Goals; Hepatic Disorder; Histology; Human, Adult; Human, Child; Investigational New Drug Application; Length; Liver; Liver Steatosis; Liver diseases; Logistics; Longitudinal Studies; Maintenance; Maintenances; Manuscripts; Methods; Modification; Monitor; NAFLD; NASH; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Non-alcoholic steatohepatitis; North America; Organ System, Cardiovascular; Pathogenesis; Patients; Performance; Phenotype; Preparation; Prevention; Procedures; Process; Proteomics; Protocol; Protocols documentation; Questionnaires; Randomized; Randomized Clinical Trials; Reporting; Reporting, Data; Research; Risk; Risk Factors; Safety; Safety Monitoring Boards; Sample Size; Sampling; Sampling Studies; Serum; Shipping; Ships; Site; Specificity; Staging; Steatohepatitis; Systems Biology; Therapeutic; Therapeutic Studies; Therapeutic Trials; Therapy Clinical Trials; Therapy Research; Time; Tissue Sample; Trials, Randomized Clinical; USFDA; United States Food and Drug Administration; United States National Institutes of Health; Universities; Vascular, Heart; Work; adult human (21+); base; biomarker; biopsy of liver; body system, hepatic; cardiovascular disorder; children; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical material; data repository; diabetes; disease causation; disease etiology; disease natural history; disease/disorder; disease/disorder etiology; disorder etiology; effective therapy; enroll; follow-up; hepatic steatosis; hepatopathy; insulin sensitizer; insulin sensitizing drugs; liver biopsy; liver disorder; long-term study; measurement of metabolism; meetings; metabolomics; natural history of disease; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; organ system, hepatic; prospective; protocol development; public health relevance; quality assurance; randomisation; randomization; randomly assigned; relational database; repository; sober; sobriety; tool; treatment trial; youngster",Continuation of the Non-Alcoholic Steatohepatitis Clinical Research Network (NASH,"Public Health Relevance: (provided by the applicant): NAFLD has emerged as a major risk factor for diabetes and cardiovascular disease in the past decade. While 5% of subjects with a fatty liver may progress to cirrhosis, NASH progresses to cirrhosis in 15% of subjects. This means that about 6 million Americans are at risk of developing cirrhosis from NAFLD; many of these are children. ",61730,ZDK1,Special Emphasis Panel,S1,8,74997,
8012896,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-505,3U01DK061731-08S1,,NIDDK:104771;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,RICHMOND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"SANYAL, ARUN J;",1876400;,3U01DK061731,02/01/2010,01/31/2011,"0-11 years old; 21+ years old; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; Active Follow-up; Adult; Ancillary Study; Antioxidants; Arts; Attention; BMI percentile; BMI z-score; Blood Serum; Body mass index; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Child; Child Youth; Children (0-21); Chronic; Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Collection; Control Groups; Controlled Clinical Trials, Randomized; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diabetes Mellitus; Diagnostic; Dimethylbiguanidine; Dimethylguanylguanidine; Disease Progression; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Eicosanoids; Enrollment; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Acids, Polyunsaturated; Fatty Liver; Feasibility Studies; Funding; Gastroplasty; Generations; Genetic; Goals; Guidelines; Health; Hepatic Disorder; Histology; Human, Adult; Human, Child; Imidodicarbonimidic diamide, N,N-dimethyl-; Incidence; Individual; Inflammatory; Insulin Resistance; Length; Lipids; Liver; Liver Steatosis; Liver diseases; Longitudinal Studies; Mass Spectrum; Mass Spectrum Analysis; Medical; Metabolic; Metabolic Pathway; Metformin; Methods; Modification; NAFLD; NASH; NIDDK; NIH; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Non-alcoholic steatohepatitis; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; PBO; Pathogenesis; Patients; Pattern; Phenotype; Photometry/Spectrum Analysis, Mass; Pioglitazone; Placebos; Polyunsaturated Fatty Acids; Principal Investigator; Procedures; Process; Production; Proteomics; Publications; Quetelet index; Randomized; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Reporting; Research; Risk; Risk Factors; Sampling; Scientific Publication; Serum; Sham Treatment; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Steatohepatitis; Surgical; Surgical Interventions; Surgical Procedure; Systems Biology; Testing; Therapeutic; Therapeutic Studies; Therapeutic Trials; Therapy Clinical Trials; Therapy Research; Tissue Sample; United States; United States National Institutes of Health; Vascular, Heart; Vitamin E; adipogenesis; adult human (21+); anti-oxidant; base; biomarker; biopsy of liver; body system, hepatic; children; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical material; control trial; data repository; diabetes; disease natural history; effective therapy; enroll; fatty acid metabolism; follow-up; hepatic steatosis; hepatopathy; improved; innovate; innovation; innovative; insight; insulin resistant; insulin sensitizer; insulin sensitizing drugs; lipid biosynthesis; lipogenesis; liver biopsy; liver disorder; long-term study; measurement of metabolism; meetings; metabolomics; minimally invasive; natural history of disease; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; novel; organ system, hepatic; oxidized lipid; polyunsaturated fatty acid; prospective; public health relevance; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; relational database; sham therapy; success; surgery; youngster",Nonalcoholic Steatohepatitis Clinical Research Network,,61731,ZDK1,Special Emphasis Panel,S1,8,104771,
8012557,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-505,3U01DK061732-08S1,,NIDDK:149966;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"MCCULLOUGH, ARTHUR JOSEPH;",1948233;,3U01DK061732,02/01/2010,01/31/2011,"0-11 years old; 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-; 21+ years old; Active Follow-up; Adult; Affect; American; Ancillary Study; Attention; Blood Plasma; Child; Child Youth; Children (0-21); Chronic; Cirrhosis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; DNA; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Enrollment; Funding; Genetic Polymorphism; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Hepatic Disorder; High Prevalence; Histologic; Histologically; Human, Adult; Human, Child; Inflammatory; L-Methionine; Length; Liver diseases; Longitudinal Studies; MODY; MTHFR; MTHFR gene; Maturity-Onset Diabetes Mellitus; Measures; Metabolic syndrome; Methionine; Methionine Metabolism; Methionine Metabolism Pathway; Methionine, L-Isomer; Methods; Modification; NAFLD; NASH; NIDDK; NIDDM; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Natural History; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-alcoholic steatohepatitis; North America; Oxidative Stress; Oxpentifylline; Pathogenesis; Patients; Pentoxifylline; Pilot Projects; Placebo Control; Plasma; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Protocol; Protocols documentation; Public Health; Randomized; Reporting; Research; Reticuloendothelial System, Serum, Plasma; Risk Factors; Sampling; Serum, Plasma; Severity of illness; Site; Sound; Sound - physical agent; Staging; Susceptibility; T2D; T2DM; Therapeutic Agents; Therapeutic Studies; Therapeutic Trials; Therapy Clinical Trials; Therapy Research; Trental; Type 2 diabetes; Type II diabetes; United States; Universities; adult human (21+); adult onset diabetes; base; biopsy of liver; burden of disease; burden of illness; children; clinical data repository; clinical data warehouse; clinical investigation; clinical material; cytokine; data repository; diabetes; diabetic patient; disease burden; disease severity; economic cost; enroll; follow-up; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; hepatopathy; indexing; interest; ketosis resistant diabetes; liver biopsy; liver disorder; long-term study; longitudinal database; maturity onset diabetes; meetings; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; non-diabetic; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; nondiabetic; patient population; pilot study; polymorphism; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; relational database; sound; success; transmethylation; treatment trial; years of life lost to disability; years of life lost to disease; youngster",Clincal Research Network in Non-Alcoholic Steatohepatitis (NASH CRN),,61732,ZDK1,Special Emphasis Panel,S1,8,149966,
8011666,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-005,3U01DK062445-08S1,,NIDDK:150001;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,PEDIATRICS,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"SUCHY, FREDERICK J;",1865865;,3U01DK062445,02/01/2010,01/31/2011,"(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid; 0-11 years old; 21+ years old; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; Acids; Acids, Bile; Acrosomal Serine Protease Inhibitor; Adrenal Cortex Hormones; Adult; Affect; After Care; After-Treatment; Aftercare; Alagille Syndrome; Alagille syndrome (AGS); Alagille-Watson Syndrome; Alagille-Watson syndrome (AWS); Alpha-1 Antiproteinase; Ancillary Study; Antitrypsin; Attenuated; Awareness; Awarenesses; Bile; Bile Acid Biosynthesis; Bile Acid Biosynthesis Pathway; Bile Acids; Bile Duct Obstruction; Bile Duct Obstruction, Intrahepatic; Bile Ducts; Bile Juice; Bile duct structure; Bile fluid; Biliary; Biliary Atresia; Biliary Stasis; Biliary Stasis, Intrahepatic; Biliary cirrhosis; Blood Serum; Body Tissues; Bone Density; Bone Mineral Density; Byler's disease; Byler's syndrome; Causality; Characteristics; Child; Child Youth; Childhood; Children (0-21); Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7beta)-; Cholestasis; Cholestasis with Peripheral Pulmonary Stenosis; Cholestasis, Intrahepatic; Cholestasis, progressive familial intrahepatic; Cirrhosis; Clinical; Clinical Data; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Corticoids; Corticosteroids; DNA; Data; Defect; Deoxyribonucleic Acid; Deoxyursocholic Acid; Development; Diagnosis; Disease; Disease Progression; Disorder; Drainage; Drainage procedure; Drugs; Dysfunction; Dysplasia, Arteriohepatic; Education; Educational aspects; Embryo; Embryonic; Etiology; Familial intrahepatic cholestasis; Fatal familial intrahepatic cholestasis syndrome; Fatal intrahepatic cholestasis; Fibrosis; Forecast of outcome; Frequencies (time pattern); Frequency; Functional disorder; Funding; Future; GWAS; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genotype; Goals; Grafting, Liver; Grant; Hepatic Cells; Hepatic Disorder; Hepatic Ductular Hypoplasia, Syndromatic; Hepatic Parenchymal Cell; Hepatic ductular hypoplasia; Hepatocyte; Hereditary; Histopathology; Human, Adult; Human, Child; Infant; Infrastructure; Inherited; Intrahepatic Cholestasis; Investigators; Knowledge; Lead; Left; Life; Liver; Liver Cells; Liver Cirrhosis, Biliary; Liver Transplant; Liver diseases; Longitudinal Studies; Medication; Mitochondria; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutation; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PAI-3; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phenotype; Physiopathology; Plasma Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; Plasminogen Activator Inhibitor III; Polymorphism, Single Base; Primary Care Physician; Principal Investigator; Prognosis; Programs (PT); Programs [Publication Type]; Progressive intrahepatic cholestasis; Protein C Inhibitor; Protein C Inhibitor, Activated; Publications; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Specimen; Researchers; Respiratory Chain; Role; SNP; SNPs; Scientific Publication; Serine or Cysteine Proteinase Inhibitor Clade A Member 5; Serum; Single Nucleotide Polymorphism; Specimen; Surgical; Surgical Interventions; Surgical Procedure; Syndrome; Testing; Therapeutic Corticosteroid; Tissues; Training; Transplantation of liver; Transplantation, Hepatic; Treatment outcome; Type 3 Plasminogen Activator Inhibitor; United States National Institutes of Health; Urinary System, Urine; Urine; Ursacholic Acid; Ursodeoxycholic Acid; Ursodiol; Watson-Miller syndrome; Work; adult human (21+); alpha 1-Antitrypsin Deficiency; arteriohepatic dysplasia; arteriohepatic dysplasia (AHD); bile acid anabolism; bile acid biosynthetic process; bile acid formation; bile acid synthesis; bile duct; bile ductule; bile obstruction; bile occlusion; biomarker; body system, hepatic; cardiovertebral syndrome; children; choleretic; cholestasis-peripheral pulmonary stenosis; clinical epidemiology; clinical investigation; clinical phenotype; disease causation; disease etiology; disease subtype; disease/disorder; disease/disorder etiology; disorder etiology; disorder subtype; double-blind placebo controlled trial; double-masked controlled study; double-masked controlled trial; drug candidate; drug/agent; fatty acid oxidation; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; hepatic ductular hypoplasia-multiple malformations syndrome; hepatofacioneurocardiovertebral syndrome; hepatopathy; improved; intervention development; liver disorder; liver transplantation; long-term study; mitochondrial; new diagnostics; next generation diagnostics; novel; novel diagnostics; organ system, hepatic; outcome forecast; pathophysiology; paucity of interlobular bile ducts; paucity of interlobular bile ducts (PILBD); pediatric; prevent; preventing; programs; prospective; recruit; repository; social role; surgery; therapy development; treatment development; web site; whole genome association studies; whole genome association study; youngster",Center for the Study of Pediatric Cholestasis,,62445,ZDK1,Special Emphasis Panel,S1,8,150001,
8013288,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-005,3U01DK062452-08S1,,NIDDK:150000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,PEDIATRICS,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"TURMELLE, YUMIRLE P;",9700530;,3U01DK062452,02/01/2010,01/31/2011,"0-11 years old; AHCPR; AHRQ; Adolescent; Adolescent Youth; Age; Agency for Health Care Policy and Research; Agency for Healthcare Research and Quality; Ancillary Study; Arkansas; Bile Duct Obstruction; Biliary Atresia; Biliary Stasis; Biochemical; Biological Neural Networks; Biopsy; Blood Serum; Caring; Cell/Tissue, Immunohistochemistry; Child; Child Youth; Childhood; Children (0-21); Cholestasis; Cirrhosis; Clinical; Clinical and Translational Science Awards; Connectionist Models; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Diagnosis; Diagnostics Research; Disease; Disorder; Education; Educational aspects; Enrollment; Event; Fibrosis; Funding; Genetics, in situ Hybridization; Goals; Grafting, Liver; Grant; Hepatic; Hepatic Disorder; Hepatic Failure; Hepatology; Hospitals, Pediatric; Human, Child; IHC; Icterus; Image; Imaging technology; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Infant; Institutes; Intervention; Intervention Strategies; Jaundice; Jaundice, Neonatal; Knowledge; Laboratories; Laboratory Study; Lead; Link; Liver Failure; Liver Fibrosis; Liver Transplant; Liver diseases; Logistic Regressions; Measures; Medical; Medical Research; Method LOINC Axis 6; Methodology; Methods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Neonatal Jaundice; Neural Network Models; Neural Network Simulation; Neural Networks (Computer); Outcome; PROV; Pathology; Patients; Pb element; Pediatric Hospitals; Perceptrons; Population; Primary Care; Primary Health Care; Primary Healthcare; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteomics; Protocol; Protocols documentation; Provider; Public Health; Queensland; Radiology; Radiology Specialty; Radiology, General; Receiver Operating Characteristics; Recommendation; Regression Analyses; Regression Analysis; Regression Diagnostics; Regressions, Logistic; Research; Research Resources; Research, Medical; Resources; Sampling; Schools, Medical; Science; Serum; Statistical Regression; Technology; Testing; Training and Education; Transplantation of liver; Transplantation, Hepatic; United States Agency for Health Care Policy and Research; United States Agency for Healthcare Research and Quality; Universities; Washington; base; bile obstruction; bile occlusion; biomarker; children; clinical care; clinical data repository; clinical data warehouse; computerized; data repository; digital; disease/disorder; enroll; fibrogenesis; heavy metal Pb; heavy metal lead; hepatic fibrosis; hepatopathy; imaging; improved; in situ Hybridization Staining Method; interventional strategy; juvenile; juvenile human; liver disorder; liver imaging; liver scanning; liver transplantation; measurement of metabolism; medical schools; metabolomics; multidisciplinary; neural network; neural network (computer simulation of nervous system); new diagnostics; next generation diagnostics; novel; novel diagnostics; pediatric; pediatrician; practice-based research network; prognostic; programs; public health medicine (field); relational database; sample collection; specimen collection; youngster",Midwest Children's Consortium,,62452,ZDK1,Special Emphasis Panel,S1,8,150000,
8011912,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-005,3U01DK062456-08S1,,NIDDK:150417;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,SURGERY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MAGEE, JOHN C;",2056036;,3U01DK062456,02/01/2010,01/31/2011,"0-11 years old; Accounting; Adverse Experience; Adverse event; Analysis, Data; Ancillary Study; Biliary Atresia; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical Trials Data Monitoring Committees; Consultations; Data; Data Analyses; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disorder; Education; Educational aspects; Family; Grafting, Liver; Hepatic Disorder; Human, Child; Investigators; Leadership; Liver Transplant; Liver diseases; Logistics; Monitor; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Patient Care; Patient Care Delivery; Patients; Preparation; Progress Reports; Publications; Quality, Data; Reporting; Reports, Progress; Research; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Safety; Safety Monitoring Boards; Scientific Publication; Site; Societies; Specimen; System; System, LOINC Axis 4; Transplantation of liver; Transplantation, Hepatic; United States; Work; children; clinical data repository; clinical data warehouse; clinical research site; clinical site; data repository; design; designing; disease/disorder; hepatopathy; liver disorder; liver transplantation; pediatric; relational database; repository; web site; working group; youngster",Childhood Liver Disease Research and Education Network Data Coordinating Center,,62456,ZDK1,Special Emphasis Panel,S1,8,150417,
8012220,U01,DK,3,Y,02/01/2010,01/31/2011,DK-08-005,3U01DK062481-08S1,,NIDDK:149593;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"HABER, BARBARA ANNE;",1870169;,3U01DK062481,02/01/2010,01/31/2011,"AIDS; Acids, Bile; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acrosomal Serine Protease Inhibitor; Adherence; Adherence (attribute); Alagille Syndrome; Alagille syndrome (AGS); Alagille-Watson Syndrome; Alagille-Watson syndrome (AWS); Alpha-1 Antiproteinase; Antitrypsin; Area; Bile Acids; Biliary Atresia; Byler's disease; Byler's syndrome; Cancer, Oncology; Care, Health; Childhood; Cholestasis with Peripheral Pulmonary Stenosis; Cholestasis, progressive familial intrahepatic; Communities; Cystic Fibrosis; Data; Data Coordinating Center; Data Coordination Center; Diagnosis; Disease; Disorder; Dysplasia, Arteriohepatic; Ensure; Familial intrahepatic cholestasis; Fatal familial intrahepatic cholestasis syndrome; Fatal intrahepatic cholestasis; Goals; Healthcare; Hepatic; Hepatic Disorder; Hepatic Ductular Hypoplasia, Syndromatic; Hepatic ductular hypoplasia; Immunologic Deficiency Syndrome, Acquired; Individual; Infrastructure; Investigation; Little's Disease; Liver; Liver diseases; Medical; Mucoviscidosis; Natural History; PAI-3; Participant; Pathogenesis; Patients; Plasma Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; Plasminogen Activator Inhibitor III; Policies; Procedures; Process; Progressive intrahepatic cholestasis; Protein C Inhibitor; Protein C Inhibitor, Activated; Protocol; Protocols documentation; Research; Research Infrastructure; Research Resources; Resources; Safety; Serine or Cysteine Proteinase Inhibitor Clade A Member 5; Spastic Diplegia; Spastic Diplegias; Therapeutic; Type 3 Plasminogen Activator Inhibitor; Watson-Miller syndrome; arteriohepatic dysplasia; arteriohepatic dysplasia (AHD); body system, hepatic; cardiovertebral syndrome; cerebral spastic infantile paralysis; cholestasis-peripheral pulmonary stenosis; disease/disorder; hepatic ductular hypoplasia-multiple malformations syndrome; hepatofacioneurocardiovertebral syndrome; hepatopathy; liver disorder; neonatal hepatitis; oncology; organ system, hepatic; paucity of interlobular bile ducts; paucity of interlobular bile ducts (PILBD); pediatric; protocol development; success; treatment strategy",Advancing our Understanding of Rare Pediatric Liver Diseases,,62481,ZDK1,Special Emphasis Panel,S1,8,149593,
8013421,U01,DK,3,Y,02/01/2010,01/31/2011,DK-02-010,3U01DK062496-07S2,,NIDDK:7700;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,SURGERY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HONG, JOHNNY C;",10012810;,3U01DK062496,02/01/2010,01/31/2011,"21+ years old; Abbreviations; Abscission; Address; Adult; American; Analysis, Data; Arm; Care, Health; Chronic; Clinical Research; Clinical Research Protocols; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Clinical, Transplantation, Organ; Complication; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disorder; Donor Exclusions; Drugs, Nonproprietary; Enrollment; Ethnic Origin; Ethnicity; Ethnicity aspects; Evaluation; Excision; Exclusion Criteria; Extirpation; Foundations; Gene Products, RNA; Generic Drugs; Graft Survival; Grafting Procedure; Grafting, Liver; Guidelines; HCV; Health; Health Care Utilization; Healthcare; Hepatic; Hepatic Disorder; Hepatitis C virus; Hepatitus C; Hepatobiliary; Human, Adult; Institution; Intervention; Intervention Strategies; Life; Liver; Liver Regeneration; Liver Transplant; Liver diseases; Living Donor Liver Transplantation; Living Donors; Measurement; Methods and Techniques; Methods, Other; Modeling; Natural History; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Participant; Patients; Post-Operative; Postoperative; Postoperative Period; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; QOL; Quality of life; Questionnaires; RNA; RNA, Non-Polyadenylated; Randomized Clinical Trials; Recovery; Recurrence; Recurrent; Removal; Research Protocols, Clinical; Research Resources; Resources; Ribonucleic Acid; Sample Size; Severity of illness; Societies; Staging; Surgical Removal; Survival Analyses; Survival Analysis; Techniques; Testing; Time; Transplant Recipients; Transplant Surgeon; Transplantation; Transplantation Surgery; Transplantation of liver; Transplantation, Hepatic; Trials, Randomized Clinical; UNOS; United Network for Organ Sharing; Upper arm; Variant; Variation; Viral; Waiting Lists; adult human (21+); base; body system, hepatic; clinical data repository; clinical data warehouse; clinical investigation; cohort; data repository; disease severity; disease/disorder; enroll; experience; generic; health care service utilization; health related quality of life; health services utilization; healthcare service utilization; healthcare utilization; hepatopathy; indexing; instrument; interventional strategy; liver disorder; liver transplantation; organ allograft; organ graft; organ system, hepatic; organ xenograft; patient population; primary outcome; programs; prospective; regenerative; relational database; resection; retransplantation; tool; transplant; transplant patient; treatment utilization",ADLDT: An Opportunity to Expand the National Donor Pool,,62496,ZDK1,Special Emphasis Panel,S2,7,7700,
8012544,U01,DK,3,Y,02/01/2010,12/31/2010,DK-08-005,3U01DK062500-08S1,,NIDDK:150001;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ROSENTHAL, PHILIP ;",1948293;,3U01DK062500,02/01/2010,12/31/2010,"0-11 years old; Accounting; Active Follow-up; Advocacy; Alagille Syndrome; Alagille syndrome (AGS); Alagille-Watson Syndrome; Alagille-Watson syndrome (AWS); Ancillary Study; Bile Duct Obstruction; Biliary Atresia; Biliary Stasis; CDC; CF patients; California; Caring; Cause of Death; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Child; Child Youth; Childhood; Children (0-21); Children with CF; Cholestasis; Cholestasis with Peripheral Pulmonary Stenosis; Chronic; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Communities; Cystic Fibrosis; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diagnosis; Disease; Disorder; Dysplasia, Arteriohepatic; Education; Educational aspects; Fibrosis; Genes; Grafting, Liver; Hepatic Disorder; Hepatic Ductular Hypoplasia, Syndromatic; Hepatic ductular hypoplasia; Hospitals, Pediatric; Human, Child; Image; Industry; Investigators; Liver; Liver Transplant; Liver diseases; Longitudinal Studies; Medical; Method LOINC Axis 6; Methodology; Methods; Mucoviscidosis; New Agents; Outcome; Patients; Pediatric Hospitals; Pediatric Surgery; Pediatric Surgical Procedures; Phase; Play; Programs (PT); Programs [Publication Type]; Public Health; Publications; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Rotavirus; Safety; Scientific Publication; Screening procedure; Site; Standardization; Steroid Compound; Steroids; Training; Transplantation; Transplantation of liver; Transplantation, Hepatic; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Validation; Watson-Miller syndrome; arteriohepatic dysplasia; arteriohepatic dysplasia (AHD); bile obstruction; bile occlusion; body system, hepatic; cardiovertebral syndrome; children; children with cystic fibrosis; cholestasis-peripheral pulmonary stenosis; clinical data repository; clinical data warehouse; clinical investigation; cohort; computerized data processing; cystic fibrosis patients; data processing; data repository; disease/disorder; follow-up; group support; hepatic ductular hypoplasia-multiple malformations syndrome; hepatofacioneurocardiovertebral syndrome; hepatopathy; imaging; imaging modality; liver disorder; liver transplantation; long-term study; new diagnostics; next generation diagnostics; novel diagnostics; organ system, hepatic; patient advocacy group; patients with CF; patients with cystic fibrosis; paucity of interlobular bile ducts; paucity of interlobular bile ducts (PILBD); pediatric; programs; prospective; public health medicine (field); relational database; sample collection; screening; screenings; signal processing; social role; specimen collection; transplant; web site; youngster",Childhood Liver Disease Research and Education Network (CHiLDREN) - UCSF (CC),,62500,ZDK1,Special Emphasis Panel,S1,8,150001,
7994530,U01,DK,3,Y,02/01/2010,04/30/2010,DK-07-500,3U01DK063865-07S2,,NIDDK:100000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AUGUSTA,UNITED STATES,PATHOLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"SHE, JIN-XIONG ;",1865197;,3U01DK063865,03/01/2003,04/30/2010,"0-11 years old; 0-6 weeks old; 15 year old; 3 year old; 4 year old; Active Follow-up; Affect; Age-Months; Allergens; Antigens, Differentiation; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Beta Cell; Biological; Blood; Blood Serum; Causality; Cells; Chemicals; Child; Child Youth; Children (0-21); Clinical; Cohort Studies; Collaborations; Collection; Complex; Concurrent Studies; D-Glucose; DNA; Data; Data Banks; Data Bases; Data Coordinating Center; Data Coordination Center; Data Quality; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diet; Dietary intake; Differentiation Antigens; Differentiation Markers; Disease; Disease Progression; Disorder; Enrollment; Enterovirus; Environment; Environmental Factor; Environmental Risk Factor; Epidemiology; Epidemiology, Family Medical History; Erythrocyte Cytoskeleton; Erythrocyte Membrane; Etiology; Expression Profiling; Expression Signature; Family Medical History; Family history of; Fatty Acids; Feces; Florida; Gastrointestinal Tract, Feces; General Population; General Public; Genes; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genotype; Glucose; Goals; HLA-DQB1; HLA-DQB1 antigen; HLA-DQbeta1; History; Human, Child; IDD; IDDM; Immune system; Immunization; Immunologic Stimulation; Immunologic, Immunochemical; Immunological Stimulation; Immunologics; Immunostimulation; Individual; Infant; Infant, Newborn; Infectious Agent; Inherited Predisposition; Inherited Susceptibility; Institution; Insulin Cell; Insulin Secreting Cell; Insulin-Dependent Diabetes Mellitus; Intake; Interview; Intravenous; Investigation; Investigators; Islet Cell; Laboratories; Lead; Life; Maintenance; Maintenances; Marker Antigens; Markers, Differentation; Mass Spectrum; Mass Spectrum Analysis; Metabolic; Molecular; Molecular Fingerprinting; Molecular Profiling; Monitor; Nature; Neonatal; Neonatal Screening; Nested Case-Control Study; Newborn Infant; Newborn Infant Screening; Newborns; Outcome Study; PBL; Paper; Pathogenesis; Patients; Pb element; Performance; Peripheral Blood Lymphocyte; Photometry/Spectrum Analysis, Mass; Populations at Risk; Predisposition gene; Process; Prospective Studies; Protocol; Protocols documentation; Psychosocial Factor; Publishing; Quality, Data; Questionnaires; Recording of previous events; Recruitment Activity; Relative; Relative (related person); Research; Research Design; Research Personnel; Research Specimen; Researchers; Reticuloendothelial System, Blood; Risk; Risk Factors; Role; Sampling; Scientist; Screening procedure; Sensitization, Immunologic; Sensitization, Immunological; Serum; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spottings; Study Subject; Study Type; Study, Nested Case-Control; Study, Outcome; Susceptibility Gene; T1 diabetes; T1D; T1DM; Target Populations; Technology; Testing; Time; Toxin; Type 1 diabetes; Urinary System, Urine; Urine; Visit; Work; autoimmune antibody; autoimmune disorder; base; biomarker; body system, allergic/immunologic; case control; children; clinical data repository; clinical data warehouse; cohort; data repository; diabetes; diabetic; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; early childhood; endocrine pancreas development; enroll; environment effect on gene; environmental risk; fifteen year old; first phase insulin response; follow-up; four year old; gene environment interaction; genetic etiology; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; high risk; high risk infant; improved; infectious organism; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; molecuar profile; molecular signature; newborn human (0-6 weeks); newborn screening; novel; organ system, allergic/immunologic; predisposing gene; prenatal; prevent; preventing; prospective; psychological stressor; psychosocial variables; recruit; relational database; screening; screenings; self reactive antibody; self recognition (immune); social role; stool; study design; three year old; time use; type I diabetes; unborn; youngster",The TEDDY study: Georgia/Florida clinical center,,63865,ZDK1,Special Emphasis Panel,S2,7,100000,
8011855,U01,DK,3,Y,02/01/2010,01/31/2011,PA-07-070,3U01DK077738-02S1,,NIDDK:181879;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BUFFALO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"LACKNER, JEFFREY M;",7755491;,3U01DK077738,02/01/2010,01/31/2011,"Abdominal Pain; Active Follow-up; Acute; Address; After Care; After-Treatment; Aftercare; Area; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Therapy, Cognitive; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Belief; Care, Health; Causality; Change of Life; Characteristics; Chronic; Client satisfaction; Climacteric; Clinic Visits; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clinical effectiveness; Cognitive; Cognitive Therapy; Colitis, Mucous; Colon, Irritable; Conditioning Therapy; Control Locus; Coupled; Data; Development; Diagnosis; Distress; Dysfunction; Economic Burden; Economics; Ensure; Etiology; Expectancy; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Feces; Functional disorder; Funding; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gastrointestinal Tract, Feces; Generations; Goals; Healthcare; Healthcare Systems; Human; Human, General; Indirect Costs; Infrastructure; Intestinal; Intestines; Irritable Bowel Syndrome; Life Style Modification; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Motivation; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Multicenter Trials; Outcome; PBO; Patient Care; Patient Care Delivery; Patient Satisfaction; Patients; Phase; Physiopathology; Pilot Projects; Placebos; Protocol; Protocols documentation; Psychotherapy, Cognitive; QOL; Quality of life; Recruitment Activity; Relative; Relative (related person); Research; Research Infrastructure; Rome; SUBGP; Sampling; Self Efficacy; Self-Administered; Severities; Sham Treatment; Site; Subgroup; Symptoms; System; System, LOINC Axis 4; Systems, Health Care; Testing; Therapeutic; Therapy, Cognition; To specify; Translating; Translatings; Treatment outcome; Validation; Visits, Clinic; base; behavior intervention; behavioral intervention; bowel; clinical investigation; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; cost; cost effectiveness; disease causation; disease etiology; disease/disorder etiology; disorder etiology; economic cost; effective therapy; follow-up; gastrointestinal disorder; improved; language translation; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; novel; pathophysiology; pilot study; psychologic; psychological; psychological distress; psychosocial; recruit; response; sham therapy; spastic colon; stool; success; theories; treatment effect; treatment program; treatment response; treatment site",Self-Administered CBT for IBS: A Multicenter Trial,,77738,ZDK1,Special Emphasis Panel,S1,2,181879,
8012489,U01,NS,3,,12/01/2005,05/31/2010,,3U01NS040069-05S1,,NINDS:50000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"LEVITON, ALAN ;",1963345;,3U01NS040069,09/30/2001,05/31/2010,"0-11 years old; 0-6 weeks old; Acquired brain injury; Age; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Attention; Auditory; Bacteria; Banking, Tissue; Binding Proteins; Biochemical; Blood Sample; Blood Serum; Blood specimen; Blood, Cord; Brain; Brain Injuries; Cells; Cellular Morphology; Cephalic; Cerebral Palsy; Cerebrum; Characteristics; Chemotherapy-Hormones/Steroids; Child; Child Development Disorders; Child Youth; Children (0-21); Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Cognitive; Cranial; Cytokine Receptors; Dependency; Dependency (Psychology); Development; Developmental Disabilities; Diagnosis, Ultrasound; Echography; Echotomography; Embryonic Tissue, Placenta; Encephalon; Encephalons; Endocrine; Endocrine Gland Secretion; Enrollment; Ethics; Event; Family; Fetal Age; Fetal Maturity, Chronologic; Follow-Up Studies; Followup Studies; Foundations; Frequencies (time pattern); Frequency; Funding; Future; GFAC; GHN; Gestation; Gestational Age; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Hormone; Growth Hormone 1; Growth Substances; Hormones; Human; Human, Child; Human, General; INFLM; Impairment; In Vitro; Infant; Infant, Newborn; Infant, Premature; Infectious Agent; Inflammation; Inflammatory; Inflammatory Response; Lead; Learning; Life; Ligand Binding Protein; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Measurable; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Mental Retardation; Molecular; Mothers; NMR Imaging; NMR Tomography; Neonatal; Nervous System, Brain; Neurologic Examination; Neurological Examination; Neuropsychologic Tests; Neuropsychological Tests; Newborn Infant; Newborns; Nuclear Magnetic Resonance Imaging; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Organism; Parents; Pb element; Performance; Perinatal Care; Pituitary Growth Hormone; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Pregnancy; Premature Infant; Prevalence; Problem behavior; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Receptors, Cytokine; Research; Research Specimen; Risk; STH; Sampling; Schools; Serum; Somatotropin; Specimen; Spottings; Survivors; Therapeutic Hormone; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Umbilical Cord; Umbilical Cord Blood; Umbilical cord structure; United States; Vision Disorders; Visual Disorder; Zeugmatography; base; behavioral problem; biomarker; brain damage; brain lesion (from injury); cell morphology; children; clinical investigation; cytokine; design; designing; developmental disease/disorder; developmental disorder; diagnostic ultrasound; disability; emotional dependency; enroll; experience; fetal; fetal cord blood; hGHN; heavy metal Pb; heavy metal lead; high risk; high school; infectious organism; living system; microbial; newborn human (0-6 weeks); postnatal; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; prevent; preventing; receptor expression; response; somatotropic hormone; sonogram; sonography; sound measurement; substantia alba; success; ultrasound; ultrasound imaging; ultrasound scanning; white matter; white matter damage; youngster",Molecular Antecedents of Brain Damage in Preterm Infants,,40069,ZNS1,Special Emphasis Panel,S1,5,50000,
8017608,U01,NS,3,,06/01/2009,05/31/2011,,3U01NS054630-05S1,,NINDS:51625;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLESTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"PALESCH, YUKO Y;",6860175;,3U01NS054630,09/15/2005,05/31/2011,"Acute; Albumins; Apoplexy; Canada; Cerebral Stroke; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Data Coordinating Center; Data Coordination Center; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Funding; Hour; Human; Human, General; Ischemic Stroke; Man (Taxonomy); Man, Modern; Measures; NIH; National Institutes of Health; National Institutes of Health (U.S.); Outcome; PBO; Patients; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Placebo Control; Placebos; Randomized; Recruitment Activity; Safety; Saline; Saline Solution; Sham Treatment; Specific qualifier value; Specified; Stroke; Strokes, Acute; Suggestion; Testing; Time; Toxic effect; Toxicities; United States National Institutes of Health; Vascular Accident, Brain; acute stroke; base; brain attack; cerebral vascular accident; clinical investigation; clinical research site; clinical site; cohort; falls; neuroprotection; phase 3 study; phase 3 trial; phase III trial; pre-clinical; preclinical; preclinical study; protocol, phase III; randomisation; randomization; randomly assigned; recruit; sham therapy; standard of care; stroke; study, phase III",Statistical and Data Coordinating Center for ALIAS and IMS 111 Trials,,54630,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,S1,5,51625,
8011748,U10,EY,3,,09/01/2009,08/31/2010,,3U10EY017826-04S1,,NEI:317317;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,OPHTHALMOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GRUNWALD, JUAN E;",1885774;,3U10EY017826,09/30/2006,08/31/2010,"Adherence; Adherence (attribute); Angiogram; Angiography; Archives; Blindness; Certification; Characteristics; Choroidal Neovascularization; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Study; Color; Combined Modality Therapy; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disciform macular degeneration; Disciform senile macular retinal degeneration; ELIG; Eligibility; Eligibility Determination; Enrollment; Extravasation; Exudative AMD; Exudative age-related macular degeneration; Eye; Eyeball; Film; Fluorescein; Fluorescein Angiography; Fluoresceins; Fundus; Goals; Group Meetings; Image; Infrastructure; Investigators; Leakage; Meetings, Group; Methods; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Neovascular AMD; Neovascular age-related macular degeneration; Neovascularization, Choroid; Ophthalmologist; Optics; Preparation; Procedures; Protocol Screening; Publications; Randomized Clinical Trials; Reader; Reading; Relative; Relative (related person); Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Safety; Scientific Publication; Secure; Site; Spillage; System; System, LOINC Axis 4; TOMO; Tomogram; Training; Training Programs; Training Support; Transmission; Trials, Randomized Clinical; Visual Acuity; Wet AMD; base; clinical data repository; clinical data warehouse; color processing; combination therapy; combined modality treatment; combined treatment; computer imaging; data repository; digital; digital imaging; enroll; imaging; improved; intervention design; multimodality therapy; neovascular; new growth; prevent; preventing; relational database; therapy design; transmission process; treatment design; treatment trial",Photograph Reading Center for the Comparison of AMD Treatment Trials,,17826,ZEY1,Special Emphasis Panel,S1,4,317317,
8011382,U10,HD,3,,01/10/2010,12/31/2010,HD-08-029,3U10HD063036-01S1,,NICHD:145511;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"PARKER, CORETTE B;",6111273;,3U10HD063036,01/10/2010,12/31/2012,"Advisory Committees; Analysis, Data; Articulation; Attention; Back; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Booklets; Brochures; Capitate; Capitate Bone; Certification; Communication; Consent Documents; Consent Forms; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Coordination Center; Development; Doctor of Philosophy; Doctor of Public Health; Dorsum; Dr.P.H.; Enrollment; Ensure; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethics Committees, Research; Genetic; Gestation; Health; Human Resources; IRBs; Individual; Informed Consent Documents; Informed Consent Forms; Infrastructure; Institutional Review Boards; Interview; Investigators; Joints; Knowledge; Leadership; Logistics; Manpower; Manuals; Measurement; Medical; Method LOINC Axis 6; Methodology; Methods; Monitor; NICHD; National Institute of Child Health and Human Development; Operation; Operative Procedures; Operative Surgical Procedures; Pamphlets; Paper; Patients; Perinatal Epidemiology; Ph.D.; PhD; Phase; Physicians; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Preterm Birth; Principal Investigator; Procedures; Process; Protocol; Protocols documentation; Publications; Quality Control; Reporting; Research; Research Design; Research Ethics Committees; Research Infrastructure; Research Personnel; Researchers; Risk; Running; SCHED; Safety; Sample Size; Schedule; Science of Statistics; Scientific Publication; Scientist; Screening procedure; Security; Site Visit; Sound; Sound - physical agent; Statistics; Stillbirth; Structure of capitate bone; Study Section; Study Type; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Teleconferences; Testing; Texas; Training; Translations; Universities; Visit; Woman; Work; base; biomarker; capitate bone; clinical research site; clinical site; data management; enroll; experience; fetal medicine; improved; instrument; meetings; member; personnel; premature childbirth; premature delivery; preterm delivery; protocol development; public health relevance; quality assurance; screening; screenings; sound; statistics; statistics/biometry; study design; surgery; web site",Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk,,63036,ZHD1,Special Emphasis Panel,S1,1,145511,
8018875,U13,AG,3,,02/01/2010,08/31/2010,PA-08-149,3U13AG031125-03S1,,NINDS:10000;,2010,NATIONAL INSTITUTE ON AGING,,NEW YORK,UNITED STATES,,14,619046555,US,NY,10019,ALZHEIMER'S DRUG DISCOVERY FOUNDATION,"FILLIT, HOWARD M.;",8644413;,3U13AG031125,09/15/2007,08/31/2010,"ALS; Academia; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyotrophic Lateral Sclerosis; Area; Basic Research; Basic Science; Case Study; Chemistry, Pharmaceutical; Cooperative Agreements; Cooperative Agreements, U-Series; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Discipline; Disease; Disorder; Drug Industry; Drugs; Education; Education, Medical, Continuing; Educational aspects; Foundations; Gehrig's Disease; Goals; Grant; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Incidence; Industry; Industry, Pharmaceutic; Intellectual Property; Investigators; Journals; Knowledge; Learning; Lewy Body Parkinson Disease; Lou Gehrig Disease; MS (Multiple Sclerosis); Magazine; Medication; Medicinal Chemistry; Minority; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Multiple Sclerosis; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Orphan Disease; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Participant; Peer Review; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Industry; Pharmaceutical Preparations; Phase; Prevention; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Public Health; Publishing; Research; Research Personnel; Research Resources; Researchers; Resources; SCHED; Schedule; Scientist; Sclerosis, Disseminated; Services; Technology Transfer; Testing; Time; Training; Translating; Translatings; U-Series Cooperative Agreements; United States National Institutes of Health; Woman; Work; case report; conference; continuing medical education; dementia of the Alzheimer type; disease/disorder; drug discovery; drug/agent; graduate student; in vitro testing; insular sclerosis; language translation; meetings; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; new therapeutics; next generation; next generation therapeutics; novel; novel therapeutics; pre-clinical; pre-clinical research; preclinical; preclinical research; prevent; preventing; primary degenerative dementia; programs; public health medicine (field); public health relevance; public-private partnership; senile dementia of the Alzheimer type; skills; symposium",Drug Discovery for Neurodegeneration,"PUBLIC HEALTH RELEVANCE: The public health problem ADDF seeks to solve is to reduce the incidence of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. By offering this conference, ADDF will increase scientists' knowledge of the drug discovery processes and catalyze them to work together to develop commercially viable and effective disease modifying therapies.",31125,NIA,National Institute on Aging Initial Review Group,S1,3,10000,
8009180,U18,IP,3,,11/01/2009,07/31/2010,IP-08-001,3U18IP000172-02S1,,ODCDC:;,2010,NATIONAL CENTER FOR IMMUNICATION AND RESPIRATORY DISEASES,,ROCHESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"SZILAGYI, PETER G;",10357492;,3U18IP000172,08/01/2008,07/31/2011,,Estimates of Influenza Vaccine Effectiveness,,172,ZCD1,Special Emphasis Panel,S1,2,350000,
8012342,U18,IP,3,,11/01/2009,07/31/2010,IP-08-001,3U18IP000183-02S2,,ODCDC:;,2010,NATIONAL CENTER FOR IMMUNICATION AND RESPIRATORY DISEASES,,MARSHFIELD,UNITED STATES,,07,074776030,US,WI,544495703,MARSHFIELD CLINIC RESEARCH FOUNDATION,"BELONGIA, EDWARD ;",8037251;,3U18IP000183,08/01/2008,07/31/2011,,Rapid Estimation of Influenza Vaccine Effectiveness in a Wisconsin Population Coh," Project Narrative Influenza vaccine effectiveness can vary from year to year, but it is not routinely measured. This project will generate timely estimates of vaccine effectiveness that will be useful for physicians, public health agencies, and the general public. It will also provide an infrastructure for future field studies of vaccine effectiveness that will be needed during the early stages of a pandemic vaccination program.",183,ZCD1,Special Emphasis Panel,S2,2,474240,
7778438,U19,MH,3,,01/19/2010,04/30/2010,PAR-08-238,3U19MH082441-03S1,,NIMH:325784;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"ROTH, BRYAN L;",1888534;,3U19MH082441,09/28/2007,04/30/2012,drug discovery; new approaches; novel approaches; novel strategies; novel strategy,Functional Selectivity: A Novel Approach for CNS Drug Discovery,,82441,ZMH1,Special Emphasis Panel,S1,3,325784,
8014429,U2G,PS,3,,04/01/2009,03/31/2010,PS-07-748,3U2GPS001093-02S1,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,MAPUTO,MOZAMBIQUE,,,,MZ,,,MOZAMBIQUE MINISTRY OF HEALTH,"GARRIDO, PAUL IVO;",10100374;,3U2GPS001093,04/01/2008,03/31/2013,,"IMPLEMENTATION OF INTEGRATED HIV/AIDS TREATMENT, CARE & PREV PROG IN THE REPUBLIC",,1093,ZPS1,Special Emphasis Panel,S1,2,1814695,
8018226,U2G,PS,3,,04/01/2009,03/31/2010,PS-09-904,3U2GPS001468-01S1,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,SAN FRANCISCO,UNITED STATES,,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"RUTHERFORD, GEORGE WILLIAMS;",2255373;,3U2GPS001468,04/01/2009,03/31/2014,,ATLANTA HQ UCSF TECHNICAL ASSISTANCE TO SUPPORT PRESIDENTS EMERGENCY PLAN FOR AID,,1468,ZPS1,Special Emphasis Panel,S1,1,1443500,
8016155,U2G,PS,3,,09/30/2009,09/29/2010,PS-09-913,3U2GPS002005-01S1,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,NEW YORK,UNITED STATES,NONE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"JUSTMAN, JESSICA E.;",1946465;,3U2GPS002005,09/30/2009,09/29/2014,,RAPID SCALE UP OF HIV/AIDS CARE AND TREATMENT SERVICES IN THE KINGDOM OF SWAZILAN,,2005,ZPS1,Special Emphasis Panel,S1,1,2000000,
8013670,U36,CD,3,,09/28/2009,09/27/2010,CD-05-048,3U36CD300430-28S3,,NCHHSTP:;,2010,"OFFICE OF THE DIRECTOR, CENTERS FOR DISEASE CONTROL & PREVENTION",,WASHINGTON,UNITED STATES,,00,120841275,US,DC,20005,ASSOCIATION OF SCHOOLS OF PUBLIC HEALTH,"KELLIHER, RITA ;",9200102;,3U36CD300430,09/28/1981,09/27/2010,,CA TO ASPH FOR THE IMPROVEMENT OF INTERACTION BETWEEN PHAS AND PHPS,,300430,ZCD1,Special Emphasis Panel,S3,28,7500,
8006933,U36,CD,3,,09/30/2009,09/29/2010,CD-05-050,3U36CD319276-10S1,,NCCDPHP:;,2010,"OFFICE OF THE DIRECTOR, CENTERS FOR DISEASE CONTROL & PREVENTION",,WASHINGTON,UNITED STATES,,00,069287779,US,DC,200371127,ASSOCIATION OF AMERICAN MEDICAL COLLEGES,"GROVER, ATUL ;",9728458;,3U36CD319276,09/30/2000,09/29/2010,,COOPERATIVE AGREEMENT WITH THE ASSOCIATION OF AMERICAN MEDICAL COLLEGES,,319276,ZCD1,Special Emphasis Panel,S1,10,50000,
8015790,U38,HM,3,,09/15/2009,09/14/2010,HM-06-602,3U38HM000022-04S1,,ODCDC:;,2010,NATIONAL CENTER FOR HEALTH MARKETING,,MARIETTA,UNITED STATES,,06,,US,GA,300682424,NATIONAL PUBLIC HEALTH INFORMATN COALTN,"ESPINO, LAURA ;",8720659;,3U38HM000022,09/15/2006,09/14/2011,,Operation Maintenance& Enhancement of a Nat'l Pub Hlth Infor/Communication Netwo,,22,ZHM1,Special Emphasis Panel,S1,4,150000,
8012005,U38,HM,3,,06/01/2009,05/31/2010,HM-08-805,3U38HM000449-02S2,,ODCDC:;,2010,NATIONAL CENTER FOR HEALTH MARKETING,,WASHINGTON,UNITED STATES,,00,877155762,US,DC,200364601,NATIONAL ASSN /CNTY/CITY/HLTH/OFFICIALS,"PESTRONK, ROBERT M.;",9811803;,3U38HM000449,06/01/2008,05/31/2013,,"STRENGTHEN & IMPROVE THE NATION'S PUB HLT CAPACITY THROUGH NAT'L, NON PROFIT, PRO",,449,ZHM1,Special Emphasis Panel,S2,2,10000,
8012250,U50,CD,3,,09/30/2009,09/29/2010,CD-05-049,3U50CD300860-22S1,,NCIRD:;,2010,"OFFICE OF THE DIRECTOR, CENTERS FOR DISEASE CONTROL & PREVENTION",,WASHINGTON,UNITED STATES,,00,,US,DC,20005,ASSOCIATION OF TEACHERS OF PREV MEDICINE,"NORDVIG, O KENT;",8999667;,3U50CD300860,05/01/1985,09/29/2010,,ENHANCE PREPARATION OF PUBLIC HEALTH & PRIMARY CARE PHYSICIANS,,300860,ZCD1,Special Emphasis Panel,S1,22,37500,
8011113,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI023808-05S4,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,OLYMPIA,UNITED STATES,,03,127347115,US,WA,985045330,WASHINGTON STATE DEPART SOC/HLTH SRVS,"BUREN, JUDE VAN;",8995264;,3U50CI023808,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,23808,ZCI1,Special Emphasis Panel,S4,5,320645,
8010748,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI123665-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,BURLINGTON,UNITED STATES,,00,809376155,US,VT,05402,VERMONT STATE DEPT OF HEALTH,"TASSLER, PATSY ;",8996895;,3U50CI123665,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,123665,ZCI1,Special Emphasis Panel,S2,5,234626,
8010743,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI123778-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,PROVIDENCE,UNITED STATES,,02,,US,RI,02908,RHODE ISLAND PUBLIC HEALTH FOUNDATION,"BANDY, UPTALA ;",8996921;,3U50CI123778,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,123778,ZCI1,Special Emphasis Panel,S2,5,307192,
8011115,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI223656-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,TRENTON,UNITED STATES,,12,806418075,US,NJ,08625,NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS,"TAN, CHRISTINA G;",9611616;,3U50CI223656,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,223656,ZCI1,Special Emphasis Panel,S2,5,753240,
8012315,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI223667-05S3,,CDC:;CID:;NCIRD:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,NEW YORK,UNITED STATES,,08,083489737,US,NY,100134006,NEW YORK CITY HEALTH/MENTAL HYGIENE,"LAYTON, MARCELLE ;",8998581;,3U50CI223667,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,223667,ZCI1,Special Emphasis Panel,S3,5,1514635,
8011114,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI223671-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,MENANDS,UNITED STATES,,21,002436061,US,NY,122042719,NEW YORK STATE DEPT OF HEALTH,"MORSE, DALE L;",8997832;,3U50CI223671,04/01/2004,12/31/2011,,ELC ,,223671,ZCI1,Special Emphasis Panel,S3,5,1081127,
8011110,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI323657-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,CHARLESTON,UNITED STATES,,99,,US,WV,25301,WEST VIRGINIA HEALTH SYSTEMS AGENCY,"HADDY, LORETTA EMILY;",9415801;,3U50CI323657,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,323657,ZCI1,Special Emphasis Panel,S3,5,267485,
8012316,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI323662-05S2,,CDC:;CID:;NCIRD:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,RICHMOND,UNITED STATES,,03,787082825,US,VA,23218,VIRGINIA STATE DEPT OF HEALTH,"WOOLARD, C DIANE;",9001121;,3U50CI323662,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,323662,ZCI1,Special Emphasis Panel,S2,5,262742,
8012310,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI323664-05S2,,CDC:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,PHILADELPHIA,UNITED STATES,,01,140533410,US,PA,19107,CITY OF PHILADELPHIA PUBLIC HEALTH DEPT,"JOHNSON, CAROLINE C;",9145931;,3U50CI323664,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,323664,ZCI1,Special Emphasis Panel,S2,5,340318,
8012303,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI323676-05S2,,CDC:;CID:;NCIRD:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,HARRISBURG,UNITED STATES,,17,614489839,US,PA,171200701,PENNSYLVANIA STATE DEPT OF HEALTH,"URDANETA, VERONICA VICTORIA;",9001147;,3U50CI323676,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,323676,ZCI1,Special Emphasis Panel,S2,5,743145,
8010741,U50,CI,3,,01/01/2009,12/31/2011,,3U50CI423659-05S3,,CDC:;CID:;NCPHI:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,RALEIGH,UNITED STATES,,04,,US,NC,27603,"NORTH CAROLINA ST DEPT/ENVIRON, HLTH, NR","MAILLARD, JEAN-MARIE ;",9395334;,3U50CI423659,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,423659,ZCI1,Special Emphasis Panel,S3,5,319452,
8012302,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI423666-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,NASHVILLE,UNITED STATES,,05,172636268,US,TN,37243,TENNESSEE STATE DEPARTMENT OF HEALTH,"KAINER, MARION ;",9003741;,3U50CI423666,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,423666,ZCI1,Special Emphasis Panel,S3,5,191330,
8016125,U50,CI,3,,09/01/2009,08/31/2010,CI-AA-011,3U50CI424921-05S1,,ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,NOUMEA CEDEX,NEW CALEDONIA,,,,NC,,98848,SECRETARIAT OF THE PACIFIC COMMUNITY,"KIEDRZYNSKI, TOM ;",9004706;,3U50CI424921,09/01/2005,08/31/2010,,DEVELOPMENT OF INFLUENZA SURVEILLANCE NETWORKS,,424921,ZCI1,Special Emphasis Panel,S1,5,194516,
8012881,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI523783-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,COLUMBUS,UNITED STATES,,15,808847933,US,OH,43215,OHIO STATE DEPARTMENT OF HEALTH,"CAMPBELL, ROBERT ;",9006388;,3U50CI523783,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,523783,ZCI1,Special Emphasis Panel,S2,5,924291,
8011112,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI523807-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,MADISON,UNITED STATES,,02,036448835,US,WI,537077850,WISCONSIN STATE DEPT OF HLTH/FAMILY SVC,"HEFFERNAN, RICHARD ;",8265471;,3U50CI523807,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,523807,ZCI1,Special Emphasis Panel,S3,5,334384,
8012309,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI623773-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,AUSTIN,UNITED STATES,,10,807391511,US,TX,78756,TEXAS STATE DEPT OF HEALTH SERVICES,"TAYLOR, JEFFREY P;",9008126;,3U50CI623773,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,623773,ZCI1,Special Emphasis Panel,S3,5,282353,
8011116,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI623779-05S2,,CDC:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,SANTA FE,UNITED STATES,,03,808389274,US,NM,87505,NEW MEXICO STATE DEPARTMENT OF HEALTH,"BAUMBACH, JOAN ;",8781094;,3U50CI623779,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,623779,ZCI1,Special Emphasis Panel,S2,5,558325,
8012311,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI623788-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,OKLAHOMA CITY,UNITED STATES,,05,143673015,US,OK,731171299,OKLAHOMA STATE DEPARTMENT OF HEALTH,"BRADLEY, KRISTY K;",9008153;,3U50CI623788,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,623788,ZCI1,Special Emphasis Panel,S3,5,481415,
8010738,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI723775-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,LINCOLN,UNITED STATES,,01,808819957,US,NE,685095026,NEBRASKA ST DEPT OF HEALTH & HUMAN SERVS,"SAFRANEK, THOMAS J;",9009297;,3U50CI723775,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,723775,ZCI1,Special Emphasis Panel,S2,5,276176,
8010735,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI723776-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,JEFFERSON CITY,UNITED STATES,,04,878092600,US,MO,65102,MISSOURI STATE DEPT/ HEALTH & SENIOR SRV,"CLARDY, SCOTT ALLEN;",9486458;,3U50CI723776,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,723776,ZCI1,Special Emphasis Panel,S2,5,317692,
8010733,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI823787-05S2,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,HELENA,UNITED STATES,,00,,US,MT,59601,MONTANA ST DEPT OF HLTH & ENVRNMTL SCIS,"WEBER, ANNE ;",9010044;,3U50CI823787,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,823787,ZCI1,Special Emphasis Panel,S2,5,657641,
8012304,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI823795-05S2,,CDC:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,PIERRE,UNITED STATES,,00,809587710,US,SD,575012536,SOUTH DAKOTA STATE DEPT OF HEALTH,"CARLSON, CHRIS ;",9010057;,3U50CI823795,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,823795,ZCI1,Special Emphasis Panel,S2,5,156603,
8012308,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI823796-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,SALT LAKE CITY,UNITED STATES,,01,959347972,US,UT,841144003,UTAH STATE DEPARTMENT OF HEALTH,"GARRETT, TERESA ;",9051439;,3U50CI823796,07/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,823796,ZCI1,Special Emphasis Panel,S3,5,323116,
8006504,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI923658-05S3,,CDC:;CID:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,PHOENIX,UNITED STATES,,04,804745420,US,AZ,85007,ARIZONA STATE DEPARTMENT OF HLTH SRVCS,"ANDERSON, SHOANA ;",10043150;,3U50CI923658,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,923658,ZCI1,Special Emphasis Panel,S3,5,1043720,
8007150,U50,CI,3,,01/01/2009,12/31/2011,CI-04-040,3U50CI923677-05S3,,CDC:;CID:;NCIRD:;ODCDC:;,2010,NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID) ,,CITY OF INDUSTRY,UNITED STATES,,38,082199324,US,CA,917463420,PUBLIC HEALTH FOUNDATION ENTERPRISES,"SCHNURR, DAVID ;",9011407;,3U50CI923677,04/01/2004,12/31/2011,,EPIDEMIOLOGY AND LABORATORY CAPACITY FOR INFECTIOUS DISEASES,,923677,ZCI1,Special Emphasis Panel,S3,5,2578943,
8009903,U62,PS,3,,02/01/2009,01/31/2010,PS-AA-239,3U62PS325222-04S1,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,WASHINGTON,UNITED STATES,,00,040054827,US,DC,20036,POPULATION SERVICES INTERNATIONAL,"STEVENS, DOUGLAS K;",9470131;,3U62PS325222,02/01/2006,01/31/2011,,INCREASING ACCESS TO HIV CONFIDENTIAL COUNSELING AND TESTING (VCT) AND ENHA,,325222,ZPS1,Special Emphasis Panel,S1,4,1581607,
8010717,U65,PS,3,,09/30/2009,09/29/2010,PS-07-764,3U65PS000813-03S1,,NCCDPHP:;ODCDC:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,WASHINGTON,UNITED STATES,,00,076890524,US,DC,20024,AMERICAN COLLEGE OF OB AND GYN,"LAWRENCE, HAL ;",9176111;,3U65PS000813,09/30/2007,09/29/2012,,NATIONAL ORGANIZATIONS WORKING TO ELIMINATE PRENATAL HIV TRANSMISSION,,813,ZPS1,Special Emphasis Panel,S1,3,60000,
8012592,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM000597-10S1,,CMHS:;,2010,Center for Mental Health Services,,LITTLE ROCK,UNITED STATES,,02,,US,AR,722076359,"DISABILITY RIGHTS CENTER, INC.","EAST, NAN ELLEN D;",10320156;,3X98SM000597,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,597,ZSM1,Special Emphasis Panel,S1,10,338851,
8012594,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM000697-10S1,,CMHS:;,2010,Center for Mental Health Services,,SACRAMENTO,UNITED STATES,,05,,US,CA,958258219,DISABILITY RIGHTS CALIFORNIA,"BLAKEMORE, CATHERINE ;",10320161;,3X98SM000697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,697,ZSM1,Special Emphasis Panel,S1,10,2477974,
8012598,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM000897-10S1,,CMHS:;,2010,Center for Mental Health Services,,DENVER,UNITED STATES,,01,,US,CO,80203,LEGAL CNTR FOR PEOPLE WITH DISABILITIES,"IVANDICK, MARK ;",10320169;,3X98SM000897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,897,ZSM1,Special Emphasis Panel,S1,10,338851,
8012600,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM000997-10S1,,CMHS:;,2010,Center for Mental Health Services,,HARTFORD,UNITED STATES,,01,,US,CT,061061551,PROTECTION & ADVOC  PERSONS/DISABILITIES,"SUSAN, WERBOFF ;",10320174;,3X98SM000997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,997,ZSM1,Special Emphasis Panel,S1,10,338851,
8012603,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001097-10S1,,CMHS:;,2010,Center for Mental Health Services,,WILMINGTON,UNITED STATES,,00,,US,DE,19801,"COMMUNITY LEGAL AID SOCIETY, INC.","HARTMAN, BRIAN ;",10320179;,3X98SM001097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1097,ZSM1,Special Emphasis Panel,S1,10,338851,
8012607,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001297-10S1,,CMHS:;,2010,Center for Mental Health Services,,TALLAHASSEE,UNITED STATES,,02,,US,FL,32301,ADVOCACY CENTER FOR PERSONS W/ DISABILIT,"FARMER, DANA ;",10320184;,3X98SM001297,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1297,ZSM1,Special Emphasis Panel,S1,10,1290935,
8012616,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001397-10S1,,CMHS:;,2010,Center for Mental Health Services,,DECATUR,UNITED STATES,,04,,US,GA,300302547,"GEORGIA ADVOCACY OFFICE, INC.","NORRIS, JOSH ;",10322203;,3X98SM001397,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1397,ZSM1,Special Emphasis Panel,S1,10,725938,
8012625,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001597-10S1,,CMHS:;,2010,Center for Mental Health Services,,HONOLULU,UNITED STATES,,01,,US,HI,968133701,HAWAII DISABILITY RIGHTS CENTER,"DELLERA, JOHN ;",10322647;,3X98SM001597,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1597,ZSM1,Special Emphasis Panel,S1,10,338851,
8012626,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001697-10S1,,CMHS:;,2010,Center for Mental Health Services,,BOISE,UNITED STATES,,02,,US,ID,837062066,"DISABILITY RIGHTS IDAHO, INC.","STILES, CORINNA ;",10322676;,3X98SM001697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1697,ZSM1,Special Emphasis Panel,S1,10,338851,
8012634,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001797-10S1,,CMHS:;,2010,Center for Mental Health Services,,CHICAGO,UNITED STATES,,07,,US,IL,606024861,"EQUIP FOR EQUALITY, INC.","TAYLOR, BARRY ;",10320204;,3X98SM001797,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1797,ZSM1,Special Emphasis Panel,S1,10,876359,
8012638,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001897-10S1,,CMHS:;,2010,Center for Mental Health Services,,INDIANAPOLIS,UNITED STATES,,07,,US,IN,462051561,INDIANA PROTECTION AND ADVOCACY SERVICES,"BOES, DAVID ;",10320206;,3X98SM001897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1897,ZSM1,Special Emphasis Panel,S1,10,483757,
8012577,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001970-10S1,,CMHS:;,2010,Center for Mental Health Services,,TUSCALOOSA,UNITED STATES,,07,045632635,US,AL,35487,UNIVERSITY OF ALABAMA IN TUSCALOOSA,"GILLESPIE, ELLEN B;",10320214;,3X98SM001970,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1970,ZSM1,Special Emphasis Panel,S1,10,356191,
8012640,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM001997-10S1,,CMHS:;,2010,Center for Mental Health Services,,WEST DES MOINES,UNITED STATES,,03,,US,IA,502652548,"IOWA PROTECTION & ADVOCACY SERVICES, INC","PIPER, SYLVIA ;",10320216;,3X98SM001997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,1997,ZSM1,Special Emphasis Panel,S1,10,338851,
8012643,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002097-10S1,,CMHS:;,2010,Center for Mental Health Services,,TOPEKA,UNITED STATES,,02,,US,KS,666033726,DISABILITY RIGHTS CENTER OF KANSAS,"NICHOLS, ROCKY ;",9704149;,3X98SM002097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2097,ZSM1,Special Emphasis Panel,S1,10,338851,
8012644,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002197-10S1,,CMHS:;,2010,Center for Mental Health Services,,FRANKFORT,UNITED STATES,,06,,US,KY,406011108,KENTUCKY STATE DEPT PROTECTION/ADVOC,"POWE, JAN ;",10320229;,3X98SM002197,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2197,ZSM1,Special Emphasis Panel,S1,10,338851,
8012645,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002297-10S1,,CMHS:;,2010,Center for Mental Health Services,,NEW ORLEANS,UNITED STATES,,02,,US,LA,701122429,ADVOCACY CENTER - - NEW ORLEANS,"PATRICK, STEPHANIE ;",10322748;,3X98SM002297,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2297,ZSM1,Special Emphasis Panel,S1,10,338851,
8012646,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002397-10S1,,CMHS:;,2010,Center for Mental Health Services,,AUGUSTA,UNITED STATES,,01,,US,ME,043382007,DISABILITY RIGHTS CENTER OF MAINE,"BAILEY, HELEN ;",10320238;,3X98SM002397,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2397,ZSM1,Special Emphasis Panel,S1,10,338851,
8012675,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002497-10S1,,CMHS:;,2010,Center for Mental Health Services,,BALTIMORE,UNITED STATES,,07,,US,MD,21201,MARYLAND DISABILITY LAW CENTER,"CAIN, LAURA ;",10320243;,3X98SM002497,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2497,ZSM1,Special Emphasis Panel,S1,10,360811,
8012682,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002697-10S1,,CMHS:;,2010,Center for Mental Health Services,,LANSING,UNITED STATES,,08,,US,MI,489114264,MICHIGAN PROTECTION AND ADVOCACY SERVICE,"CARUSO, GERI ;",10320253;,3X98SM002697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2697,ZSM1,Special Emphasis Panel,S1,10,753534,
8012705,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002797-10S1,,CMHS:;,2010,Center for Mental Health Services,,MINNEAPOLIS,UNITED STATES,,05,,US,MN,554011780,LEGAL AID SOCIETY OF MINNEAPOLIS,"HOOPES, PAMELA ;",10320255;,3X98SM002797,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2797,ZSM1,Special Emphasis Panel,S1,10,355107,
8012579,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002970-10S1,,CMHS:;,2010,Center for Mental Health Services,,ANCHORAGE,UNITED STATES,,00,,US,AK,995034580,DISABILITY LAW CENTER OF ALASKA,"FLEURANT, DAVID C;",10320265;,3X98SM002970,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2970,ZSM1,Special Emphasis Panel,S1,10,338851,
8012707,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM002997-10S1,,CMHS:;,2010,Center for Mental Health Services,,JEFFERSON CITY,UNITED STATES,,04,,US,MO,651094510,MISSOURI PROTECTION & ADVOCACY SERVICES,"DE LOYOLA, SHAWN T;",10320270;,3X98SM002997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,2997,ZSM1,Special Emphasis Panel,S1,10,442035,
8012714,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003097-10S1,,CMHS:;,2010,Center for Mental Health Services,,HELENA,UNITED STATES,,00,,US,MT,596010820,DISABILITY RIGHTS MONTANA,"FRANKS - ONGOY, BERNADETTE ;",10320275;,3X98SM003097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3097,ZSM1,Special Emphasis Panel,S1,10,338851,
8012725,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003197-10S1,,CMHS:;,2010,Center for Mental Health Services,,LINCOLN,UNITED STATES,,01,,US,NE,685081919,NEBRASKA ADVOCACY SERVICES,"EVANS, ERIC ;",10323497;,3X98SM003197,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3197,ZSM1,Special Emphasis Panel,S1,10,338851,
8012726,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003297-10S1,,CMHS:;,2010,Center for Mental Health Services,,LAS VEGAS,UNITED STATES,,03,,US,NV,891465611,NEVADA DISABILITY ADVOCACY AND LAW CTR,"BIGLEY, LYNNE ;",10320288;,3X98SM003297,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3297,ZSM1,Special Emphasis Panel,S1,10,338851,
8012727,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003397-10S1,,CMHS:;,2010,Center for Mental Health Services,,CONCORD,UNITED STATES,,02,,US,NH,033014971,"DISABILITIES RIGHTS CENTER, INC.","COHEN, RICHARD A;",10320290;,3X98SM003397,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3397,ZSM1,Special Emphasis Panel,S1,10,338851,
8012734,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003497-10S1,,CMHS:;,2010,Center for Mental Health Services,,TRENTON,UNITED STATES,,12,,US,NJ,086082404,DISABILITY RIGHTS NEW JERSEY,"LUKENS, LOUANN ;",10323464;,3X98SM003497,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3497,ZSM1,Special Emphasis Panel,S1,10,544280,
8012739,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003597-10S1,,CMHS:;,2010,Center for Mental Health Services,,ALBUQUERQUE,UNITED STATES,,01,,US,NM,87110,"PROTECTION AND ADVOCACY SYSTEM, INC.","JACKSON, JAMES ;",10320300;,3X98SM003597,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3597,ZSM1,Special Emphasis Panel,S1,10,338851,
8012740,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003697-10S1,,CMHS:;,2010,Center for Mental Health Services,,SCHENECTADY,UNITED STATES,,21,,US,NY,123052397,NYS COMMISSION /QUALITY CARE & ADVOCACY,"CAROL, ACKERMAN ;",10320308;,3X98SM003697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3697,ZSM1,Special Emphasis Panel,S1,10,1239380,
8012747,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003897-10S1,,CMHS:;,2010,Center for Mental Health Services,,BISMARCK,UNITED STATES,,00,,US,ND,585014071,PROTECTION AND ADVOCACY PROJECT,"LARSEN, TERESA ;",9704219;,3X98SM003897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3897,ZSM1,Special Emphasis Panel,S1,10,338851,
8012748,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM003997-10S1,,CMHS:;,2010,Center for Mental Health Services,,COLUMBUS,UNITED STATES,,15,,US,OH,432152999,OHIO LEGAL RIGHTS SERVICE,"WEEKS, WINNIFRED ;",10323648;,3X98SM003997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,3997,ZSM1,Special Emphasis Panel,S1,10,853490,
8012750,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004097-10S1,,CMHS:;,2010,Center for Mental Health Services,,OKLAHOMA CITY,UNITED STATES,,05,,US,OK,731065487,"OKLAHOMA DISABILITY LAW CENTER, INC.","SUBLETT, MELISSA ;",10320323;,3X98SM004097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4097,ZSM1,Special Emphasis Panel,S1,10,338851,
8012751,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004197-10S1,,CMHS:;,2010,Center for Mental Health Services,,PORTLAND,UNITED STATES,,01,,US,OR,97204,OREGON ADVOCACY CENTER,"JOONDEPH, ROBERT C;",9291462;,3X98SM004197,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4197,ZSM1,Special Emphasis Panel,S1,10,338851,
8012754,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004297-10S1,,CMHS:;,2010,Center for Mental Health Services,,HARRISBURG,UNITED STATES,,17,,US,PA,171031049,DISABILITY RIGHTS NETWORK PENNSYLVANIA,"TERRY, MCCARTHY ;",10320333;,3X98SM004297,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4297,ZSM1,Special Emphasis Panel,S1,10,871188,
8012757,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004497-10S1,,CMHS:;,2010,Center for Mental Health Services,,PROVIDENCE,UNITED STATES,,02,,US,RI,029034204,RHODE ISLAND DISABILITY LAW CENTER,"SHERLOCK, KATHLEEN ;",10320338;,3X98SM004497,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4497,ZSM1,Special Emphasis Panel,S1,10,338851,
8012759,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004597-10S1,,CMHS:;,2010,Center for Mental Health Services,,COLUMBIA,UNITED STATES,,02,,US,SC,292044034,PROTECTION & ADVOCACY /PEOPLE WITH DISAB,"DARWIN, ANNA MARIA ;",10324249;,3X98SM004597,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4597,ZSM1,Special Emphasis Panel,S1,10,348631,
8012760,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004697-10S1,,CMHS:;,2010,Center for Mental Health Services,,PIERRE,UNITED STATES,,00,,US,SD,575012479,SOUTH DAKOTA ADVOCACY SERVICES,"MARSHALL, DIANNA L;",10320348;,3X98SM004697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4697,ZSM1,Special Emphasis Panel,S1,10,338851,
8012761,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004797-10S1,,CMHS:;,2010,Center for Mental Health Services,,NASHVILLE,UNITED STATES,,05,,US,TN,372125385,DISABILITY LAW & ADVOCACY CTR OF TENN,"SHEA, SHIRLEY A;",10320353;,3X98SM004797,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4797,ZSM1,Special Emphasis Panel,S1,10,469251,
8012763,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004897-10S1,,CMHS:;,2010,Center for Mental Health Services,,AUSTIN,UNITED STATES,,10,,US,TX,78757,"ADVOCACY, INC.","THYSSEN, MONICA ;",10320358;,3X98SM004897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4897,ZSM1,Special Emphasis Panel,S1,10,1721535,
8012585,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004970-10S1,,CMHS:;,2010,Center for Mental Health Services,,PHOENIX,UNITED STATES,,04,,US,AZ,850122069,ARIZONA CENTER FOR DISABILITY LAW,"MYERS, EDWARD ;",10320362;,3X98SM004970,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4970,ZSM1,Special Emphasis Panel,S1,10,488056,
8012764,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM004997-10S1,,CMHS:;,2010,Center for Mental Health Services,,SALT LAKE CITY,UNITED STATES,,01,,US,UT,841031125,DISABILITY LAW CENTER,"MALONEY, EILEEN ;",10320367;,3X98SM004997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,4997,ZSM1,Special Emphasis Panel,S1,10,338851,
8012768,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005097-10S1,,CMHS:;,2010,Center for Mental Health Services,,MONTPELIER,UNITED STATES,,00,,US,VT,056022916,"VERMONT PROTECTION AND ADVOCACY, INC.","PAQUIN, EDWARD ;",10320369;,3X98SM005097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5097,ZSM1,Special Emphasis Panel,S1,10,338851,
8012901,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005197-10S1,,CMHS:;,2010,Center for Mental Health Services,,RICHMOND,UNITED STATES,,07,,US,VA,232303034,VIRGINIA OFFICE FOR PROTECTION/ ADVOCACY,"CONFER, SHERRY ;",10320377;,3X98SM005197,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5197,ZSM1,Special Emphasis Panel,S1,10,524215,
8012902,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005397-10S1,,CMHS:;,2010,Center for Mental Health Services,,SEATTLE,UNITED STATES,,07,,US,WA,981042691,DISABILITY RIGHTS WASHINGTON,"STROH, MARK ;",10320379;,3X98SM005397,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5397,ZSM1,Special Emphasis Panel,S1,10,440948,
8012903,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005497-10S1,,CMHS:;,2010,Center for Mental Health Services,,CHARLESTON,UNITED STATES,,02,,US,WV,253011826,"WEST VIRGINIA ADVOCATES, INC.","SIMIRYAN, TOVLI ;",10320386;,3X98SM005497,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5497,ZSM1,Special Emphasis Panel,S1,10,338851,
8012904,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005597-10S1,,CMHS:;,2010,Center for Mental Health Services,,MADISON,UNITED STATES,,02,,US,WI,537033263,DISABILITY RIGHTS WISCONSIN,"KERSCHENSTEINER, KRISTIN ;",10320391;,3X98SM005597,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5597,ZSM1,Special Emphasis Panel,S1,10,406952,
8012968,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005697-10S1,,CMHS:;,2010,Center for Mental Health Services,,CHEYENNE,UNITED STATES,,00,,US,WY,82001,"PROTECTION AND ADVOCACY SYSTEM, INC.","THOBRO, JEANNE ;",10320393;,3X98SM005697,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5697,ZSM1,Special Emphasis Panel,S1,10,338851,
8012605,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005797-10S1,,CMHS:;,2010,Center for Mental Health Services,,WASHINGTON,UNITED STATES,,00,,US,DC,20002,UNIVERSITY LEGAL SERVICES,"BROWN, JANE ;",10320398;,3X98SM005797,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5797,ZSM1,Special Emphasis Panel,S1,10,338851,
8012618,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM005897-10S1,,CMHS:;,2010,Center for Mental Health Services,,HAGATNA,UNITED STATES,,,,US,GU,969104911,GUAM LEGAL SERVICES CORPORATION,"PARKER, HAROLD ;",10320406;,3X98SM005897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,5897,ZSM1,Special Emphasis Panel,S1,10,181547,
8012716,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM006997-10S1,,CMHS:;,2010,Center for Mental Health Services,,SAIPAN,UNITED STATES,,,,US,MP,96950,NORTHERN MARIANAS PROTECTION & ADV SYS,"SABLAN, JIMMY ;",10323640;,3X98SM006997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,6997,ZSM1,Special Emphasis Panel,S1,10,181547,
8012755,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM007297-10S1,,CMHS:;,2010,Center for Mental Health Services,,SAN JUAN,UNITED STATES,,,,US,PR,009401309,OFFICE OMBUDSMAN PERSONS WITH DISABIL,"MORALES, MARGARET ;",10320420;,3X98SM007297,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,7297,ZSM1,Special Emphasis Panel,S1,10,524479,
8012769,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM007897-10S1,,CMHS:;,2010,Center for Mental Health Services,,FREDERIKSTED,UNITED STATES,,,,US,VI,008404038,"VIRGIN ISLANDS ADVOCACY, INC.","HEADLEY-LAMONT, AMELIA ;",10320422;,3X98SM007897,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,7897,ZSM1,Special Emphasis Panel,S1,10,181547,
8012721,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM007997-10S1,,CMHS:;,2010,Center for Mental Health Services,,FARMINGTON,UNITED STATES,,03,,US,NM,874028801,NATIVE AMERICAN DISABILITY LAW,"YANAN, THERESE E;",10320427;,3X98SM007997,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,7997,ZSM1,Special Emphasis Panel,S1,10,181547,
8012743,X98,SM,3,,10/01/2009,09/30/2011,,3X98SM008097-10S1,,CMHS:;,2010,Center for Mental Health Services,,RALEIGH,UNITED STATES,,13,,US,NC,276081370,DISABILITY RIGHTS NORTH CAROLINA,"VICKI, SMITH ;",10320435;,3X98SM008097,10/01/2009,09/30/2011,,Protection & Advocacy for Individuals with Mntl Illness,,8097,ZSM1,Special Emphasis Panel,S1,10,687389,
7983015,R00,DA,4,,12/01/2009,11/30/2010,PA-07-297,4R00DA024761-03,,NIDA:249000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,JUPITER,UNITED STATES,,22,148230662,US,FL,334585284,SCRIPPS FLORIDA,"MILLER, COURTNEY A;",7016942;,4R00DA024761,12/01/2009,11/30/2012,"2(1H)-Pyrimidinone, 4-amino-; 21+ years old; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ATP-protein phosphotransferase; Acetylation; Addiction, Cocaine; Addiction, Drug; Adult; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Automobile Driving; Behavioral; Biological Models; Brain region; CHIP assay; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; ChIP (chromatin immunoprecipitation); Chemical Dependence; Chromatin; Cocaine; Cocaine Dependences; Cognitive; Common Rat Strains; Contin, MS; Cornu Ammonis; Coupled; Cues; Cytosine; DNA; DNA Methylation; DNA Methyltransferase; DNA Modification; DNA Modification Methylases; DNA Modification Methyltransferases; DNA Modification Process; DNA-Methyltransferases; Data; Deoxyribonucleic Acid; Dependence, Drug; Dependences, Cocaine; Development; Diacetylmorphine; Diamorphine; Disease; Disorder; Dnmt; Doctor of Philosophy; Drivings, Automobile; Drug Addiction; Drug Dependency; Drug usage; Drugs; EC 2.1.1.113; EC 2.7.2-; ERK MAP Kinases; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Extinction; Extinction (Psychology); Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Genes; Global Change; Goals; Grant; Heroin; Hippocampus; Hippocampus (Brain); Histone Acetylase; Histone Acetylation; Histones; Human; Human, Adult; Human, General; Immune Precipitation; Immunoprecipitation; Infumorph; Infusion; Infusion procedures; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kadian; Knockout Mice; Knowledge; Laboratories; Learning; Literature; MAP kinase; MAPK; MSir; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Manuscripts; Marshal; Medication; Memory; Mentors; Methods and Techniques; Methods, Other; Methylation; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Mitogen-Activated Protein Kinases; Mitotic; Model System; Modeling; Models, Biologic; Modification; Modification Methylases; Molecular; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphine; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Nucleus Accumbens; Null Mouse; Oramorph; Oramorph SR; Organism; PTSD; Peptide Biosynthesis, Ribosomal; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphorylation; Physiologic; Physiological; Play; Post-Translational Modifications; Post-Translational Protein Processing; Post-Traumatic Stress Disorders; Posttranslational Modifications; Prefrontal Cortex; Process; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Synthesis, Ribosomal; Protein/Amino Acid Biochemistry, Post-Translational Modification; Publishing; Rat; Rattus; Relapse; Reporting; Research; Resistance; Retrieval; Rewards; Role; Roxanol; Schizophrenia; Schizophrenic Disorders; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Specific DNA-methyltransferase; Statex SR; Stimulus; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Techniques; Testing; Therapeutic Intervention; Threonine/Tyrosine Protein Kinase; Time; Training; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Ventral Tegmental Area; Work; abused drugs; addiction; adult human (21+); amygdaloid nuclear complex; anticancer research; base; behavioral extinction; biological signal transduction; bisulfite; cancer research; chromatin immunoprecipitation; chromatin modification; clinical relevance; clinically relevant; conditioned fear; conditioning; craving; dementia praecox; disease/disorder; driving; drug maintenance; drug of abuse; drug reward; drug seeking behavior; drug use; drug/agent; drugs abused; drugs of abuse; experience; extracellular signal related kinase; fear conditioning; genetic promoter element; glycogen synthase a kinase; hippocampal; histone acetyltransferase; histone modification; hydrogen sulfite; hydrosulfite; hydroxyalkyl protein kinase; infancy; infantile; insight; intervention therapy; interventional strategy; living system; memory process; memory retrieval; microarray technology; model organism; neural circuit; neural circuitry; neuronal; novel; novel therapeutic intervention; phosphorylase b kinase kinase; preference; protein synthesis; resistant; response; schizophrenic; social role; traumatic neurosis; ventral tegmentum",Epigenetic Mechanisms of Memories Associated with Cocaine Reward,"As drug addiction develops, addicts learn to associate the rewarding effects ofthe drug with stimuli that are  present at the time of drug use. Using an animal model of addiction, this proposal explores the hypothesis  that cocaine-induced modifications to an organism's epigenome are integral to the formation and expression  of the aberrant memories that contribute to relapse in addicts.",24761,NSS,,,3,249000,
7996702,R00,GM,4,,01/04/2010,12/31/2010,PA-06-133,4R00GM083145-03,,NIGMS:249000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,GENETICS,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MURRAY, JOHN I;",7893197;,4R00GM083145,12/01/2007,12/31/2012,"Address; Algorithms; Animals; Binding Sites; Biology; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cell Fate Control; Cell Fate Regulation; Cells; Combining Site; Complex; Data; Development; Disease; Disorder; Ectopic Expression; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Expression Profiling; Expression Signature; Fertilized Egg; Fertilized Ovums; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genetic; Genomics; Goals; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Individual; Knock-out; Knockout; Knowledge; Laboratories; Lead; Logic; Malignant Neoplasms; Malignant Tumor; Maps; Messenger RNA; Methods; Modeling; Molecular Fingerprinting; Molecular Profiling; Organism; Outcome; Ovum, Fertilized; Pattern; Pb element; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Reactive Site; Regulation; Research; Resolution; Sequence-Specific Posttranscriptional Gene Silencing; Sorting - Cell Movement; Structure of zygote; Targetings, Gene; Testing; Tissues; Training; Transcription Regulatory Protein; Transcriptional Regulatory Protein; Transgenes; Work; Zygote; base; cell type; chromatin modification; combinatorial; disease/disorder; experiment; experimental research; experimental study; heat shock transcription factor; heavy metal Pb; heavy metal lead; in vivo; living system; mRNA; malignancy; molecuar profile; molecular signature; neoplasm/cancer; overexpression; research study; sorting; transcription factor; zygote",Dissecting the Regulation of Gene Expression during C. elegans Embryogenesis,"Knowledge of how transcription factors act in development can provide information about how the same  transcription factors function in cancers or disease when inappropriately activated or inactivated.  Furthermore, the rules governing combinatorial transcriptional regulatory logic we aim to discover should  apply broadly across biology, including in disease.",83145,NSS,,,3,249000,
8012017,R00,GM,4,,01/25/2010,12/31/2010,,4R00GM085136-03,,NIGMS:249000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,NONE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"WANG, DONG ;",9225973;,4R00GM085136,07/01/2008,12/31/2012,"(SP-4-2)-Diamminedichloroplatinum; Abscission; Active Sites; Affect; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Biochemical Genetics; Biological; Bypass; CDDP; Cancers; Catalysis; Cell Communication and Signaling; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chemical Agents; Chemicals; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Combining Site; Complex; Cysplatyna; DDP; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Maintenance; DNA Polymerase II; DNA Polymerase epsilon; DNA Repair; DNA Repair Pathway; DNA Sequence Rearrangement; DNA Stability; DNA lesion; DNA-Dependent DNA Polymerase II; DNA-Dependent RNA Polymerase II; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Defect; Deoxyribonucleic Acid; Dichlorodiammineplatinum; Dinucleoside Phosphates; Drug Design; Drugs; EC 2.7.7.6; Elements; Elongation Factor; Ensure; Excision; Extirpation; Factor, Elongation; Foundations; Funding; Future; GTP; Gene Products, RNA; Gene Transcription; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic, Biochemical; Genetics-Mutagenesis; Goals; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Histidine; Histidine, L-isomer; Hydrogen Bonding; Intermediary Metabolism; Intracellular Communication and Signaling; Knowledge; L-Histidine; Laboratories; Lead; Life; METBL; Malignant Neoplasms; Malignant Tumor; Medication; Metabolic Processes; Metabolism; Methods; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; Mutation; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleotides; Pathway interactions; Pb element; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphates; Platinum; Platinum Black; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Play; Point Mutation; Pol II; Postdoc; Postdoctoral Fellow; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; Pt element; RNA; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA Polymerases; RNA, Non-Polyadenylated; Radiation; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Rearrangement; Removal; Research; Research Associate; Resistance; Resolution; Ribonucleic Acid; Roentgen Rays; Role; SII transcription elongation factor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sites, Active; Sodium Chloride; Sodium chloride (NaCl); Solvents; Spinal Column; Spine; Structure; Subcellular Process; Surgical Removal; System; System, LOINC Axis 4; TFIIS; TFIIS elongation factor; Transcription; Transcription Elongation; Transcription, Genetic; Unscheduled DNA Synthesis; Vertebral column; Work; X-Radiation; X-Rays; Xrays; adduct; analog; backbone; base; biological signal transduction; chromatin remodeling; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; conformation; conformational state; design; designing; dinucleotide; drug/agent; elongation factor SII; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; inorganic phosphate; insight; malignancy; molecular dynamics; multidisciplinary; mutant; neoplasm/cancer; pathway; post-doc; post-doctoral; programs; ray (radiation); resection; resistant; response; salt; seal; simulation; social role; strand transfer protein alpha; transcription elongation factor A; transcription elongation factor S-II; transcription factor IIS; transcription factor S-II",Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II,"This knowledge will provide us strutural insights for transcriptional fidelity control, DNA damage recognition  and DNA repair. In addition, this konowledge will have implications for rational drug design for cancer and  other transcription related human diseases.",85136,NSS,,,3,249000,
8006004,R00,NS,4,,01/15/2010,12/31/2010,,4R00NS064303-02,,NINDS:248999;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PISCATAWAY,UNITED STATES,NEUROSCIENCES,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"RASIN, MLADEN-ROKO ;",9341139;,4R00NS064303,03/01/2009,12/31/2012,"A5 Antigen; Affect; Antibodies; Axon; B2 antigen, Xenopus; Brain; Brain Stem; Brainstem; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cessation of life; Code; Coding System; Corticospinal Tracts; Data; Death; Development; Disease; Disorder; Electron Microscopy; Embryo; Embryonic; Encephalon; Encephalons; Family; GP145-TRKC; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Pool; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Genetics, in situ Hybridization; Goals; Homeo Boxes; Homeobox; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Life; Light; Mammals, Mice; Mediating; Medulla Spinalis; Mental disorders; Mental health disorders; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Molecular; Morphology; Mother Cells; Movement; Murine; Mus; NRP; NRP1; NRP1 Protein; NT3 Growth Factor Receptor; NTRK3; NTRK3 Protein; NTRK3 Receptor; NTRK3 gene; Natural regeneration; Neocortex; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neurons; Neuropilin-1; Neurotrophic Tyrosine Kinase Receptor Type 3; Neurotrophin 3 Receptor; Npn-1 Protein; Null Mouse; Phase; Photoradiation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein-Tyrosine Kinase TRKC; Psychiatric Disease; Psychiatric Disorder; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RT-PCR; RTPCR; Receptor Signaling; Receptor, trkC; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Role; Sema III Receptor; Semaphorin III Receptor; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spinal Cord; Stem cells; Synapses; Synaptic; System; System, LOINC Axis 4; TRKC; TRKC Tyrosine Kinase; Testing; Thalamic structure; Thalamus; Time; Transcription; Transcription, Genetic; Transgenic Mice; Unspecified Mental Disorder; VEGF165R; Vascular Endothelial Cell Growth Factor 165 Receptor; Work; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; axonal guidance; biological signal transduction; body movement; combinatorial; disease/disorder; gastrulation; homotypical cortex; in situ Hybridization Staining Method; in vivo; isocortex; knockout animal; mental illness; microarray technology; mutant; neocortical; neopallium; neuronal; neurotrophic factor; neurotrophin; neutrophin; novel; plexin; postnatal; programs; psychological disorder; regenerate; reverse transcriptase PCR; shRNA; short hairpin RNA; small hairpin RNA; social role; thalamic; transcription factor; trkC Protein",Molecular Control of Corticospinal System Formation by Intermediate Targets,"Results should have high impact on the understanding of sensorimotor integration and should open or  extend horizons for novel treatment approaches for neurological and psychiatric disorders affecting CS tract  and thalamus, and for regeneration of severed CS tract in adulthood.",64303,NSS,,,2,248999,
8013257,R37,NS,4,,01/15/2010,12/31/2010,,4R37NS017323-29,,NINDS:424682;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ITHACA,UNITED STATES,OTHER BASIC SCIENCES,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"HARRIS-WARRICK, RONALD M;",1866715;,4R37NS017323,04/01/1981,12/31/2012,,"Neurotransmitters, Neuromodulators and Motor Systems",,17323,SMI,Sensorimotor Integration Study Section,,29,424682,
8010461,R44,GM,4,,01/22/2010,11/30/2010,PA-08-050,4R44GM087784-02,,NIGMS:887123;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MCFARLAND,UNITED STATES,,02,610347713,US,WI,53558,"INVIVO SCIENCES, LLC.","RUFANOVA, VICTORIYA ALEKSANDROVNA;",10501938;,4R44GM087784,06/17/2009,11/30/2011,,"Engineered tissue-based, high-throughput compound profiling",,87784,ZRG1,Special Emphasis Panel,,2,887123,
7662904,R44,HD,4,,01/15/2010,12/31/2010,PA-07-280,4R44HD058403-02,,NICHD:370740;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BELMONT,UNITED STATES,,07,137091000,US,MA,02478,"PRAXIS, INC.","KLEDARAS, JOANNE B;",7702252;,4R44HD058403,01/15/2010,12/31/2011,"0-11 years old; Address; Algorithms; Arts; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Child; Child Youth; Children (0-21); Children with Disabilities; Cognitive; Cognitive Discrimination; Coin; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Computer Programs; Computer software; Computers; Controlled Study; Curriculum; Decision Making; Development; Disabled Children; Discrimination; Discrimination (Psychology); Editorial Comment; Editorial Comment (PT); Educational Curriculum; Educational process of instructing; Effectiveness; Environment; Evaluation; Government; Handicapped Children; Human, Child; Individual; Instruction; Intellectual disability; Intellectual functioning disability; Intellectual limitation; Judgment; Kanner's Syndrome; Learning; Method LOINC Axis 6; Methodology; Methods; Modeling; Names; Ni element; Nickel; Outcome; Participant; Performance; Persons; Phase; Population; Preparedness; Procedures; Programs (PT); Programs [Publication Type]; Psychological reinforcement; Published Comment; Readiness; Reinforcement; Reinforcement (Psychology); Reinforcement Schedule; Relative; Relative (related person); Sampling; Schools; Series; Shapes; Simulate; Software; Special Education; Stimulus; Students; Teaching; Training; Training Programs; Viewpoint; Viewpoint (PT); Work; autism spectrum disorder; base; children; computer program/software; design; designing; improved; instructor; programs; prototype; remedial/special education; skills; skills training; teacher; user-friendly; validation studies; youngster",Functional Money Skills Readiness Training: Teaching Relative Values,"Our objective is to complete development of the MERIT suite, a computer-based curriculum  That can potentially prepare children who have the requisite cognitive capacity to use money  independently. We believe that the MERIT product suite has the potential to significantly  improve the effectiveness of money skills instruction for children with intellectual disabilities,  many of whom make at best slow and uneven progress in learning this critical skill.",58403,ZRG1,Special Emphasis Panel,,2,370740,
7753840,F30,AG,5,,03/01/2010,02/28/2011,PA-05-151,5F30AG030316-04,,NIA:32061;,2010,NATIONAL INSTITUTE ON AGING,,SEATTLE,UNITED STATES,GENETICS,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"SALIPANTE, STEPHEN J;",8718114;,5F30AG030316,03/01/2007,02/28/2011,"0-6 weeks old; 21+ years old; Adult; Affect; Age; Aging; Animals; Apoptosis; Apoptosis Pathway; Biology; Brain; C elegans; C.elegans; Caenorhabditis elegans; Cell Death, Programmed; Cell Lineage; Cell division; Cells; Complex; DNA Replication; DNA Sequence; DNA Synthesis; DNA biosynthesis; Development; Disease; Disorder; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Fertilized Egg; Fertilized Ovums; Generations; Genetic Alteration; Genetic Change; Genetic Markers; Genetic defect; Genome; Genotype; Health; Heart; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; History; Human, Adult; Individual; Infant, Newborn; Length; Liver; Liver Cells; M Phase; M phase (cell cycle); Mammalia; Mammals; Mammals, General; Mammals, Mice; Maps; Methods; Mice; Microscopic; Mitosis; Mitosis Stage; Mother Cells; Murine; Mus; Mutation; Nematoda; Nematodes; Nervous System, Brain; Newborn Infant; Newborns; Organ; Organism; Organogenesis; Ovum, Fertilized; Pattern; Phylogenetic Analysis; Phylogenetics; Population Study; Process; Production; Progenitor Cells; Recording of previous events; Role; Senescence; Series; Somatic Mutation; Statistical Methods; Stem cells; Structure; Structure of zygote; Technology; Time; Tissue Sample; Trees; Zygote; adult human (21+); anticancer research; base; body system, hepatic; cancer research; daughter cell; disease/disorder; experiment; experimental research; experimental study; genome mutation; living system; microbial; migration; newborn human (0-6 weeks); organ system, hepatic; research study; roundworm; senescence; senescent; social role; zygote",Phylogenetic Fate Mapping: Following Cellular Lineages in Embryogenesis and Aging,,30316,ZRG1,Special Emphasis Panel,,4,32061,
7799768,F30,AG,5,,03/01/2010,02/28/2011,PA-05-151,5F30AG032826-02,,NIA:25380;,2010,NATIONAL INSTITUTE ON AGING,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"MCGEE, JEAN SUH;",9296194;,5F30AG032826,03/01/2009,02/29/2012,"Affect; Age; Binding; Binding (Molecular Function); Cell Aging; Cell Senescence; Cells; Cellular Aging; Chromatin; Chromosomes; Complex; Consensus; DNA; Deoxyribonucleic Acid; Disease; Disorder; EC 2.7; Enzymes; Est2 protein; Eukaryota; Eukaryote; Event; Genetic Materials; Goals; Kinases; Lead; Length; Materials, Genetic; Modeling; Molecular Interaction; Mutagenesis, Site-Directed; Pb element; Phosphorylation; Phosphotransferases; Population; Protein Phosphorylation; Proteins; Public Health; Recruitment Activity; Regulation; Regulatory Protein; Research; Retirement; Role; Senescence, Cellular; Senescence, Replicative; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; TERT protein; Targeted DNA Modification; Targeted Modification; Telomerase; Telomere Shortening; Testing; Transphosphorylases; Yeasts; age dependent; age related; cell age; disease/disorder; dosage; eukaryotida; ever shorter teleomeres protein 2; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; in vivo; public health medicine (field); recruit; regulatory gene product; social role; telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase catalytic subunit; telomere; yeast protein",The role of Rif1p preferential elongation of short telomeres,,32826,ZRG1,Special Emphasis Panel,,2,25380,
7783760,F30,AG,5,,03/01/2010,02/28/2011,PA-05-151,5F30AG034033-02,,NIA:33453;,2010,NATIONAL INSTITUTE ON AGING,,MINNEAPOLIS,UNITED STATES,PATHOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"LIN, AVA YUN;",9260948;,5F30AG034033,03/01/2009,02/28/2014,"Actin Filaments; Actins; Affect; Aging; Baculovirus Expression System; Basic Research; Basic Science; Becker dystrophy; Becker muscular dystrophy; Becker muscular dystrophy (BMD); Becker pseudohypertrophic muscular dystrophy; Becker-Kiener muscular dystrophy; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Biomedical Research; Biophysics; Cells; Chemistry, Biological; Clinical Sciences; Coloring Agents; Defect; Disease; Disorder; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Duchenne/Becker muscular dystrophy; Duchenne/Becker muscular dystrophy (DMD/BMD); Dyes; Dystrophin; Dystrophin-Related Protein; Dystrophin-Related Protein 1; Electromagnetic, Laser; Ellis-van Creveld (EvC) syndrome; Engineering; Engineerings; Fluorescence; Fluorescence Anisotropy; Foundations; Future; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hereditary; Human; Human, General; Inherited; Insecta; Insects; Invertebrates, Insects; Investigators; Label; Lasers; Lead; Learning; Light; Man (Taxonomy); Man, Modern; Microfilaments; Molecular; Molecular Interaction; Muscle; Muscle Proteins; Muscle Tissue; Muscle function; Muscular Dystrophies; Muscular Dystrophy, Becker; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Mutation; Myodystrophica; Myodystrophy; Myofilaments; Optics; Paper; Pb element; Peptide Domain; Phenotype; Photoradiation; Physiologic pulse; Procedures; Progressive Muscular Dystrophy, Duchenne Type; Protein Domains; Proteins; Protocol; Protocols documentation; Pseudohypertrophic Muscular Dystrophy, Childhood; Pulse; Radiation, Laser; Research; Research Personnel; Research Technics; Researchers; Senescence; Site; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Surface; Techniques, Research; Tertiary Protein Structure; Therapeutic; Time; Training; UTRN Protein; Utrophin; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; benign X-linked recessive muscular dystrophy; career; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; design; designing; disease/disorder; experiment; experimental research; experimental study; flexibility; gene product; genome mutation; heavy metal Pb; heavy metal lead; improved; insight; interest; mild X-linked recessive muscular dystrophy; muscle aging; muscle degeneration; mutant; phosphorescence; progressive muscular dystrophy of childhood; progressive muscular dystrophy, Becker type; protein protein interaction; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; research study; senescent; therapeutic development; tool",Spectroscopic Probes of Protein-Protein Interactions in Muscle Degeneration,,34033,ZRG1,Special Emphasis Panel,,2,33453,
7761655,F30,DA,5,,01/01/2010,12/31/2010,PA-05-151,5F30DA024931-02,,NIDA:46380;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"GUEZ, DANIELLE ;",7837098;,5F30DA024931,01/01/2009,12/31/2011,"21+ years old; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Addiction, Cocaine; Adult; Animals; Area; Association Learning; Associative Learning; Attenuated; Behavior; Body Tissues; Brain; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Cocaine; Cocaine Dependences; Cocaine Users; Common Rat Strains; Conditioning, Classical; Conditionings, Classical; Corpus Striatum; Corpus striatum structure; Cues; Cytofluorometry, Flow; D1 receptor; D2 receptor; DRD2; DRD2 Receptor; Dependences, Cocaine; Dopamine D1 Receptor; Dopamine D2 Receptor; Drug Exposure; Drugs; Encephalon; Encephalons; Environment; Expression Profiling; Expression Signature; FOS gene; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; G0S7; Gal isorepressor protein; Gal repressor protein; GalR protein; GalR repressor protein; GalS protein; Gene Expression; Genes; Genes, Immediate-Early; Genes, LacZ; Glia; Glial Cells; Goals; Hour; Human, Adult; Immediate-Early Genes; Injection of therapeutic agent; Injections; Investigators; Kolliker's reticulum; Label; LacZ; LacZ Genes; Lead; Learning; Lesion; Literature; Locomotor Activity; Mammals, Rats; Mediating; Medication; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Minority; Modeling; Molecular; Molecular Analysis; Molecular Fingerprinting; Molecular Profiling; Motor Activity; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Nucleus Accumbens; PCR; Pavlovian conditioning; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Polymerase Chain Reaction; Population; Protooncogene FOS; RNA, Messenger; RT-PCR; RTPCR; Rat; Rattus; Regimen; Relapse; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; Scanning; Self Administration; Societies; Sorting - Cell Movement; Sortings, Fluorescence-Activated Cell; Stimulus; Striate Body; Striatum; Techniques; Testing; Time; Tissues; Transcriptase; Transgenic Organisms; Users, Cocaine; Validation; adult human (21+); base; beta-D-Galactosidase; beta-D-Galactoside galactohydrolase; beta-Galactosidase; brain tissue; c fos; c-fos Gene; c-fos Proto-Oncogenes; cell sorting; cell type; classical conditioning; cocaine exposure; cocaine use; drug mechanism; drug/agent; experiment; experimental research; experimental study; flow cytophotometry; heavy metal Pb; heavy metal lead; lac Z Protein; mRNA; mRNA Expression; molecuar profile; molecular signature; nerve cement; neural; neuroadaptation; neuronal; novel; relating to nervous system; research study; reverse transcriptase PCR; social role; sorting; striatal; tool; transgenic; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",FACS: A novel method to study neurons altered during cocaine sensitization,,24931,ZRG1,Special Emphasis Panel,,2,46380,
7761217,F30,DC,5,,02/01/2010,01/31/2011,PA-05-151,5F30DC009542-03,,NIDCD:46380;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"BUSHEY, MICHAEL A;",8796205;,5F30DC009542,02/01/2008,01/31/2013,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 21+ years old; Ablation; Activin-Binding Protein; Acute; Adult; Adverse Late Effects; Afferent Neurons; Age; Aged 65 and Over; Aging; Animals; Autoregulation; Birth; Body Tissues; Bone-Derived Transforming Growth Factor; Cell Communication and Signaling; Cell Culture Techniques; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Defect; Development; Doxycycline; Education; Educational aspects; Elderly; Elderly, over 65; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Embryonic Tissue; Epithelium; Epithelium, Olfactory; Equilibrium; Exhibits; Family; Family member; Feedback; Follistatin; Fostering; Genetic; Genetic Models; Goals; Homeostasis; Human, Adult; Intracellular Communication and Signaling; Investigation; Knock-out; Knockout; Knockout Mice; Label; Laboratories; Late Effects; Lead; Length of Life; Life; Longevity; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Milk Growth Factor; Modeling; Models, Genetic; Molecular; Molecular Genetic; Molecular Genetics; Mouse Strains; Multipotent Stem Cells; Murine; Mus; Nerve Cells; Nerve Unit; Neural Cell; Neural Growth; Neurobiology; Neurocyte; Neuronal Growth; Neurons; Neurons, Afferent; Neurons, Sensory; Null Mouse; Olfaction; Olfactions; Olfactory Epithelium; Organ System; Parturition; Pathway interactions; Pattern; Pb element; Perinatal; Phenocopy; Physicians; Physiological Homeostasis; Platelet Transforming Growth Factor; Play; Population; Production; Proliferating; QOL; Quality of life; Regulation; Research; Role; Science; Scientist; Senescence; Sensory; Sensory Cell Afferent Neuron; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Smell; Smell Perception; System; System, LOINC Axis 4; TGF B; TGF-beta; TGFbeta; Technology; Tet; Tetanus Helper Peptide; Time; Tissues; Training; Transforming Growth Factor beta; Vibramycin; adult animal; adult human (21+); advanced age; age dependent; age related; aged; alpha-6-Deoxyoxytetracycline; balance; balance function; biological signal transduction; body system; cell type; elders; embryo tissue; experiment; experimental research; experimental study; extracellular; geriatric; heavy metal Pb; heavy metal lead; information gathering; interest; late life; later life; life span; lifespan; mature animal; member; mouse model; multipotent progenitor; neurobiological; neurogenesis; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; older adult; older person; pathway; prevent; preventing; research study; senescent; senior citizen; social role; sustentacular cell",Extrinsic Signaling in the Homeostatic Regulation of Olfactory Neurogenesis,,9542,CDRC,Communication Disorders Review Committee,,3,46380,
7767745,F30,DK,5,,01/01/2010,12/31/2010,PA-05-151,5F30DK083194-02,,NIDDK:30397;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"WU, DAVINA ;",9348354;,5F30DK083194,01/01/2009,12/31/2011,"Address; Adipocytes; Adipose Cell; Adipose tissue; Attenuated; Autoregulation; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Biomedical Research; Blood Glucose; Blood Sugar; Blood Vessels; Body Tissues; Bone Marrow; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Cytofluorometry, Flow; Cytokine Receptors; Cytokine Signal Transduction; Cytokine Signaling; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Epidemic; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gene Targeting; Genetic Models; Goals; Hematopoietic; Hepatic Proliferation Inhibitor; Histological Technics; Histological Techniques; Histology; Homeostasis; IL-13; IL-4; IL13; IL4; IL4 Protein; INFLM; Immune; Immune response; Immune system; Immunity; In Situ; Inflammation; Inflammation Mediators; Inflammatory; Insulin Resistance; Interleukin Receptor; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Interleukins; Intermediary Metabolism; Intracellular Communication and Signaling; L arginine amidinohydrolase; Laboratories; Lipocytes; Liver Immunoregulatory Protein; Liver-Derived Inhibitory Protein; Lymphocyte Stimulatory Factor 1; MCGF-2; METBL; MODY; Macrophage Activation; Maintenance; Maintenances; Mammals, Mice; Mast Cell Growth Factor-2; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Processes; Metabolism; Mice; Microfluorometry, Flow; Modeling; Models, Genetic; Murine; Mus; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Obesity; Peripheral; Physiologic; Physiological; Physiological Homeostasis; Play; Public Health; Publishing; Receptors, Cytokine; Regulation; Reporter; Reporting; Reticuloendothelial System, Bone Marrow; Role; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stimulus; Stromal Cells; T-Cell Growth Factor 2; T2D; T2DM; Targetings, Gene; Technics, Histologic; Techniques, Histologic; Tissues; Type 2 diabetes; Type II diabetes; Weight Gain; Weight Increase; Wing; adipose; adiposity; adult onset diabetes; arginase; arginine amidinase; base; biological signal transduction; body system, allergic/immunologic; body weight gain; body weight increase; canavanase; cell type; corpulence; corpulency; corpulentia; cytokine; design; designing; disease/disorder; flow cytophotometry; host response; immunoresponse; in vivo; insulin resistant; insulin sensitivity; intervention design; ketosis resistant diabetes; macrophage; maturity onset diabetes; mouse model; novel; obese; obese people; obese person; obese population; organ system, allergic/immunologic; public health medicine (field); public health relevance; receptor expression; reconstitute; reconstitution; social role; therapeutic target; therapy design; treatment design; unspecified interleukin; vascular; white adipose tissue; wt gain; yellow adipose tissue",Cytokine-expressing cells in adipose tissue and metabolic regulation,,83194,ZRG1,Special Emphasis Panel,,2,30397,
7766949,F30,ES,5,,02/01/2010,01/31/2011,PA-05-151,5F30ES017207-02,,NIEHS:27720;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,GALVESTON,UNITED STATES,BIOCHEMISTRY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"TANN, ANNE ;",9410439;,5F30ES017207,02/01/2009,10/31/2013,"2(1H)-Pyrimidinone, 4-amino-; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; ANXA5; AP Endonuclease; AP Endonuclease Class I; AP Lyase; AP endonuclease, human; APE1; APEN; APEN protein, human; APEX Nuclease; APEX Nuclease (Multifunctional DNA Repair Enzyme); APEX nuclease (multifunctional DNA repair enzyme) 1, human; APEX nuclease, human; APEX-1 protein, human; APEX1; APEX1 protein, human; APX; ATF; Abscission; Acetylcysteine; Acetylin; Active Oxygen; Affect; Aging Process; Aging-Related Process; Airbron; Allen & Hanburys Brand of Acetylcysteine; Anchorin CII; Anions; Annexin A5 Protein; Annexin V; Antioxidants; Apoptosis; Apoptosis Pathway; Apoptotic; Apurine-Apyrimidine Endonuclease; Apurinic DNA Endonuclease; Apurinic Endonuclease; Apurinic/Apyrimidinic (Abasic) Endonuclease; Apurinic/Apyrimidinic Exonuclease; Assay; Base Excision Repairs; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Bristol-Myers Squibb Brand of Acetylcysteine; Bristol-Myers Squibb Brand of Acetylcysteine Sodium Salt; Broncholysin; Brunac; CBP-I; Calphobindin I; Cancer Induction; Cancers; Causality; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell-Death Protease; CellLine; Cells; Cleaved cell; Collaborations; Comet Assay; Complex; Cytosine; DNA Base Excision Repair; DNA Damage; DNA Injury; DNA Lyase (Apurinic or Apyrimidinic); DNA Polymerases; DNA lesion; DNA, Mitochondrial; DNA-(apurinic or apyrimidinic site) lyase; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deamination; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonuclease (Apurinic or Apyrimidinic); Depurination; Down-Regulation; Down-Regulation (Physiology); Downregulation; Doxycycline; Dysfunction; EC 2.7.7.7; Electron Transport; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endodeoxyribonuclease (Apurinic or Apyrimidinic); Endonexin II; Etiology; Excision; Extirpation; Extravasation; Fabrol; Ferricytochrome c; Ferrocytochrome c; Fibroblasts; Fluatox; Fluimucetin; Fluimucil; Fluorescence; Fluprowit; Functional disorder; Gel Electrophoresis, Single-Cell; Generations; Genes; Genes, p53; Genome; Genotoxins; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; H2O2; HAP1; HAP1 DNA repair enzyme, human; HAP1 protein, human (nuclease); HeLa; Heavy Metals; Hela Cells; Histones; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypoxia; Hypoxic; ICE-like protease; Induction of Apoptosis; Infection; Inpharzam Brand of Acetylcysteine; Intracellular Communication and Signaling; Italy; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Kinetic; Kinetics; Knockout Mice; L-Alpha-acetamido-beta-mercaptopropionic Acid; Laboratories; Lead; Leakage; Lentivirinae; Lentivirus; Lipids; Lipocortin-V; MMC; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Mercapturic Acid; Metals; Metals, Heavy; Mice; Mice, Knock-out; Mice, Knockout; Microinjections; Mitochondria; Mitochondrial DNA; Molecular Interaction; Muco Sanigen; Mucocedyl; Mucolator; Mucolyticum; Mucomyst; Mucosolvin; Mucret; Multifunctional DNA Repair Enzyme; Murine; Mus; Mutagens; N-Acetyl Cysteine; N-Acetyl-L-cysteine; N-Acetylcysteine; N-acetyl-3-mercaptoalanine; N-terminal; NAC; NAC Zambon; NH2-terminal; Neo-Fluimucil; Nuclear; Nucleus; Null Mouse; O-(biotinylcarbazoylmethyl)hydroxylamine; Optipect Hustengetr??nk; Oxidases; Oxidation-Reduction; Oxidative Stress; Oxygen Deficiency; Oxygen Radicals; P53; PAP-I; PP4; Parvolex; Pathway interactions; Pb element; Physiopathology; Placental Anticoagulant Protein I; Placental Protein 4; Play; Pro-Oxidants; Production; Produpharm Lappe Brand of Acetylcysteine; Proteins; REF-1; REF1; RNA, Small Interfering; Reaction; Reactive Oxygen Species; Recombinants; Redox; Ref-1 protein, human; Removal; Repairs, Base Excision; Research; Respaire; Respiration; Roberts Brand of Acetylcysteine; Role; Running; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Spillage; Subfamily lentivirinae; Surgical Removal; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Testing; Tetracycline Antibiotic; Tetracyclines; Thiemann Brand of Acetylcysteine; Thromboplastin Inhibitor; Time; Tixair; Transgenes; Transgenic Organisms; Tumor Protein p53 Gene; UPSA Brand of Acetylcysteine; Ung DNA glycosylase; Universities; Ura-DNA glycosidase; Ura-DNA glycosylase; VAC-Alpha; Vascular Anticoagulant-Alpha; Vibramycin; Virus-Lenti; Zambon Brand of Acetylcysteine; Zyma Brand of Acetylcysteine; activating transcription factor; aldehyde reactive probe; alpha-6-Deoxyoxytetracycline; annexin A5; anti-oxidant; base; biological signal transduction; biotin-CMHA; c jun; c-jun Gene; cancer cell; carcinogenesis; caspase; chemical reaction; cleaved; cultured cell line; cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; cystein protease; cystein proteinase; cysteine endopeptidase; cytochrome c; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; electron transfer; environmental agent; experiment; experimental research; experimental study; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; genotoxic agent; heavy metal Pb; heavy metal lead; human APEX1 protein; knock-down; malignancy; member; mitochondrial; mitochondrial dysfunction; mitochondrial genome; mitochondrial megachannel; mitochondrial membrane; mitochondrial permeability transition pore; mtDNA; mutant; neoplasm/cancer; novel therapeutic intervention; oxidation reduction reaction; oxidative damage; pathophysiology; pathway; prevent; preventing; recombinase; redox factor 1, human; ref1 protein, human; repair; repaired; research study; resection; respiratory; respiratory mechanism; siRNA; social role; transgenic; uracil N-glycosidase; uracil N-glycosylase; uracil-DNA glycosidase; uracil-DNA glycosylase",Role of ROS-Induced DNA Damage in Mitochondria-Regulated Apoptosis,,17207,ZRG1,Special Emphasis Panel,,2,27720,
7758333,F30,HL,5,,12/01/2009,11/30/2010,PA-08-021,5F30HL094052-02,,NHLBI:45904;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,NONE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"NEMETSKI, SONDRA MAUREEN;",8006725;,5F30HL094052,12/01/2008,11/30/2010,"3-D structure; 3-dimensional structure; 3D structure; ATPase, Actin-Activated; Actins; Adenosine Triphosphatase, Myosin; Adhesives; Affect; Aldehyde-Lyases; Aldolases; Anemia; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Biology; Blood; Blood erythrocyte; Blood normocyte; Cell Locomotion; Cell Migration; Cell Movement; Cell membrane; Cell surface; Cells; Cellular Migration; Cerebral Malaria; Cerebrum; Cessation of life; Chemistry, Biological; Cilia; Communicable Diseases; Complex; Computational Biology; Computer Simulation; Computerized Models; Crystallographies; Crystallography; Cytoplasmic Membrane; Death; Development, Economic; Development, Economical; Disease; Disorder; Docking; Drug resistance; Economic Development; Enzymes; Erythrocytes; Erythrocytic; Family; Fever; Flagella; Future; Homology Modeling; Human; Human, General; Hyperthermia; Imagery; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Invaded; Knowledge; Laboratories; Malaria; Malaria, Cerebral; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mathematical Model Simulation; Mathematical Models and Simulations; Membrane; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Molecular; Molecular Interaction; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Motor; Movement; Mutagenesis, Site-Directed; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Organ; Organism; Pain; Painful; Paludism; Parasites; Plasma Membrane; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Protein Family; Proteins; Protozoa; Protozoal; Publishing; Pyrexia; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reporting; Research; Resolution; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Simulation, Computer based; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sporozoites; Staging; Structure; Tail; Targeted DNA Modification; Targeted Modification; Techniques; Training; Universities; Visualization; Washington; Work; base; blood corpuscles; blood vessel occlusion; body movement; cell motility; combat; computational modeling; computational models; computational simulation; computational studies; computer based models; computer studies; computerized modeling; computerized simulation; design; designing; disease/disorder; drug discovery; drug resistant; effective therapy; febrile; febris; gene product; in silico; interdisciplinary approach; living system; member; membrane structure; myosin ATP phosphohydrolase (actin translocating); novel; pathogen; plasmalemma; public health relevance; resistance to Drug; resistant to Drug; social; success; three dimensional structure; virtual simulation",Computational & Biochemical Studies of the Malarial Blood Stage Invasion Complex,,94052,ZRG1,Special Emphasis Panel,,2,45904,
7768479,F30,HL,5,,02/01/2010,01/31/2011,PA-08-021,5F30HL095280-02,,NHLBI:31966;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ANN ARBOR,UNITED STATES,PATHOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"JO, STEPHANIE Y;",9299343;,5F30HL095280,02/01/2009,01/31/2012,"21+ years old; ABD-B; AF-4; AF4; AF5Q31; AF5Q31 Gene; AF9; ALL1; ALL1 Fused Gene From 5q31; Accounting; Acute leukemia; Address; Adult; Blood (Leukemia); C-terminal; Childhood; Chimera Protein; Chimeric Proteins; Complex; DNA Sequence Rearrangement; DNA-Dependent RNA Polymerase II; DNA-Dependent RNA Polymerase III; Dependence; Diagnosis; Disease; Disorder; Drosophila; Drosophila genus; EC 2.1.1; EC 2.7; Escalante syndrome; Family; Family member; Fragile X; Fragile X Syndrome; Fruit Fly, Drosophila; Fusion Protein; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; GeneHomolog; Genes; Genes, Homeo Box; Genes, Homeobox; Goals; HOX gene; HOX1.7; HOX1G; HOXA9; HOXA9 gene; HRX; HTRX; Histones; Homeo Domain Proteins; Homeobox A9; Homeobox Family Gene; Homeobox Family Protein; Homeobox Genes; Homeobox Proteins; Homeodoamin Gene; Homeodomain Family Protein; Homeodomain Proteins; Homeoproteins; Homeotic Genes; Homeotic Proteins; Homolog; Homologous Gene; Homologous Protein; Homologue; Human; Human, Adult; Human, General; Kinases; L-Lysine; LAF4; LAF4 gene; Leukemias, General; Leukemogenesis/Lymphomagenesis; Lysine; MEIS1; MEIS1 gene; MGC1934; MLL; MLL gene; MLLT2; MLLT2 gene; MLLT3; MLLT3 gene; Man (Taxonomy); Man, Modern; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Mediating; Mental Retardation; Methylation; Methyltransferase; Mixed Lineage Leukemia Gene; Molecular Target; Myeloid-Lymphoid Leukemia Gene; Patients; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Polycomb; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Family; Protein Homolog; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; ProteinHomolog; Proteins; RNA Polymerase B; RNA Polymerase C; RNA Polymerase II; RNA Polymerase III; Rearrangement; Regulation; Renpenning syndrome 2; Role; SET Domain; TRX1; Targetings, Gene; Topoisomerase; Transcription Activation; Transcription Elongation; Transcriptional Activation; Transphosphorylases; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; adult human (21+); autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; cofactor; disease/disorder; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; fruit fly; gene product; high risk; inhibitor; inhibitor/antagonist; insight; leukemia; leukemogenesis; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; mar(X) syndrome; marker X syndrome; mental retardation-macroorchidism syndrome; methylase; overexpression; pediatric; social role; therapeutic target; transmethylase",The role of MLL fusion Partner Associated Complex (MPAC) in leukemia,,95280,ZRG1,Special Emphasis Panel,,2,31966,
7784443,F30,HL,5,,02/10/2010,02/09/2011,PA-08-021,5F30HL095319-02,,NHLBI:46380;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"POTENTA, SCOTT E.;",9350950;,5F30HL095319,02/10/2009,02/09/2012,"7B4 Antigen; 7B4 protein; Activin A Receptor Type II-Like 1; Activin A Receptor, Type II-Like Kinase; Address; Adventitial Cell; Animal growth regulators, transforming growth factors; Basement membrane; Biological; Blood Vessels; CAM 120/80; CD144 Antigen; CDH5; Cadherin-1; Cancers; Cardiac; Cell Communication and Signaling; Cell Junctions; Cell Signaling; Cells; Deposit; Deposition; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; E-Cadherin; Endothelial Cells; Endothelium; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Family; Fibroblasts; Fibrosis; Frequencies (time pattern); Frequency; Gene Transcription; Genetic Transcription; In Vitro; Intercellular Junctions; Intracellular Communication and Signaling; Leiomyocyte; Malignant Neoplasms; Malignant Tumor; Mediating; Mesenchymal; Methods and Techniques; Methods, Other; Mice, Transgenic; Molecular; Myocytes, Smooth Muscle; Pathway interactions; Pericapillary Cell; Pericytes; Perivascular Cell; Play; Proliferating; Proteins; RNA Expression; Receptor Protein; Recruitment Activity; Reporting; Role; Rouget Cells; Serine/threonine-protein kinase Receptor R3 Precursor; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Snails; Structure; Supporting Cell; TGF-B Superfamily Receptor Type I; Techniques; Transcription; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transforming Growth Factors; Transgenic Mice; Tumor Growth Factors; Uvomorulin; VE-Cadherin; Vascular Endothelial Cadherin; Vascular Endothelial Cadherin 1; activin receptor-like kinase 1; angiogenesis; biological signal transduction; cadherin 5; design; designing; disease/disorder; epithelial to mesenchymal transition; gene product; in vivo Model; malignancy; neoplasm/cancer; pathway; receptor; recruit; social role; vascular; vasculogenesis",The Role of Endothelial-to-Mesenchymal Transition in Angiogenesis,,95319,ZRG1,Special Emphasis Panel,,2,46380,
7763796,F30,HL,5,,02/01/2010,01/31/2011,PA-08-021,5F30HL095320-02,,NHLBI:37387;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLESTON,UNITED STATES,ANATOMY/CELL BIOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"PALATINUS, JOSEPH A.;",9300822;,5F30HL095320,02/01/2009,01/31/2014,"Arrhythmia; Arterioloscleroses; Binding; Binding (Molecular Function); Blood Pressure; Blood Pressure, High; Blotting, Western; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cardiomyopathies; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cessation of life; Coloring Agents; Communicating Junction; Connexin 43; Connexin43; Cx43; D-Glucose; Death; Dextrose; Diabetes Mellitus; Dyes; Dysfunction; ECG; EKG; Echocardiogram; Echocardiography; Electrocardiogram; Electrocardiography; Electron Microscopy; Energy Transfer; Exhibits; Functional disorder; Gap Junctions; Glucose; Heart; Heart Arrhythmias; Heart Diseases; Hyperglycemia; Hypertension; Immune Precipitation; Immunoprecipitation; In Vitro; Lead; Life; Low-resistance Junction; Maps; Membrane; Molecular Interaction; Mycocardium Disease; Myocardial; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Nexus; Nexus Junction; Occluding Junctions; Optics; Organ System, Cardiovascular; Pb element; Peptides; Phosphorylation; Physiologic; Physiological; Physiopathology; Predisposition; Protein Phosphorylation; Proteins; Recovery; Risk; Rodent Model; Susceptibility; Testing; Tight Junctions; Transthoracic Echocardiography; V (voltage); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Ventricular Dysfunction; Western Blotting; Western Blottings; Western Immunoblotting; Zonula Occludens; cell imaging; cellular imaging; circulatory system; design; designing; diabetes; diabetic; diabetic patient; gene product; heart disorder; heart sonography; heavy metal Pb; heavy metal lead; hyperglycemic; hyperpiesia; hyperpiesis; hypertensive disease; membrane structure; myocardium disorder; pathophysiology; protein blotting; protein crosslink; sound measurement; sugar; voltage",Connexin 43 gap junction dynamics in the diabetic heart,,95320,ZRG1,Special Emphasis Panel,,2,37387,
7769898,F30,HL,5,,02/06/2010,02/05/2011,PA-08-021,5F30HL095324-02,,NHLBI:38315;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"GAETA, STEPHEN A;",9399638;,5F30HL095324,02/06/2009,02/05/2013,"Action Potentials; Address; Arrhythmia; Blood Coagulation Factor IV; Ca++ element; Calcium; Cardiac; Cardiac Arrhythmia; Cardiac Myocytes; Cardiocyte; Causality; Cavia; Cells; Cessation of life; Coagulation Factor IV; Complex; Coupling; Death; Death, Sudden, Cardiac; Dependence; Disease; Disorder; Drugs, Nonproprietary; Etiology; Event; Factor IV; Frequencies (time pattern); Frequency; Future; Generic Drugs; Goals; Guinea Pigs; Health; Heart; Heart Arrhythmias; Heart myocyte; Hybrids; Image; In Vitro; Individual; Lead; Life; Link; Mammals, Guinea Pigs; Math Models; Membrane; Methods; Molecular; Molecular Target; Morphology; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocytes; Myocytes, Cardiac; Pb element; Play; Prevention; Property; Property, LOINC Axis 2; Relative; Relative (related person); Research; Role; Strategic Planning; System; System, LOINC Axis 4; Theoretical Studies; Therapeutic; Time; Uncertainty; V (voltage); Ventricular; Work; cardiac rhythm; cardiomyocyte; cell type; computational studies; computer studies; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; doubt; effective therapy; experiment; experimental research; experimental study; generic; heart cell; heart rhythm; heavy metal Pb; heavy metal lead; imaging; mathematical model; mathematical modeling; membrane structure; prevent; preventing; research study; social role; therapeutic target; voltage",In vitro characterization of cardiac alternans mechanism,,95324,ZRG1,Special Emphasis Panel,,2,38315,
7798597,F30,HL,5,,02/01/2010,01/31/2011,PA-08-021,5F30HL095325-02,,NHLBI:26794;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,IOWA CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"HE, BEIXIN J;",9241104;,5F30HL095325,02/01/2009,01/31/2012,"A Kinase Anchor Protein 13; A kinase (PRKA) anchor protein 13, human; A-Kinase (PRKA) Anchor Protein 13; AKAP13 protein, human; ANG-(1-8)Octapeptide; Active Oxygen; Address; Adrenergic Agents; Adrenergic Drugs; Adrenergic Receptor; Adrenergics; Adrenoceptors; Affect; Aldosterone; Aldosterone Antagonists; Aldosterone Receptor; Aldosterone Receptors; Aldosteronism; AngII; Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Angiotensin II; Angiotensin II Receptor; Angiotensin-(1-8) Octapeptide; Antisera; Apoptosis; Apoptosis Pathway; Assay; BP control; BRX; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Body Tissues; Brx protein, human; CD143 Antigens; Ca++ element; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium/calmodulin-dependent protein kinase; Calmodulin; Carboxycathepsin; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiovascular Diseases; Cause of Death; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Clinical Trials; Clinical Trials, Unspecified; Coagulation Factor IV; Common Rat Strains; Confocal Microscopy; Data; Dipeptidyl Peptidase A; Drugs; Dysfunction; Effectiveness; Equilibrium; Event; Factor IV; Fibrosis; Figs; Figs - dietary; Fluorescence; Functional disorder; Gene Transcription; Genetic; Genetic Condition; Genetic Diseases; Genetic Models; Genetic Transcription; Gifts; Goals; HA-3 peptide, human; HT31; HTRPY; Heart; Heart Diseases; Heart Hypertrophy; Heart failure; Heart myocyte; Hereditary Disease; Ht31 protein, human; Human; Human, General; Hyperaldosteronism; Hypertrophy; Immune Sera; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Vitro; Intracellular Communication and Signaling; Isoforms; Kininase A; Kininase II; Knock-out; Knockout; L-Methionine; LBC; Label; Lbc protein, human; Life; Link; MCR; MLR; Mammals, Mice; Mammals, Rabbits; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediator; Mediator of Activation; Mediator of activation protein; Medical center; Medication; Methionine; Methionine, L-Isomer; Mice; Microscopy, Confocal; Mineralocorticoid Receptor; Mineralocorticoids; Models, Genetic; Modification; Molecular; Molecular Disease; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocytes; Myocytes, Cardiac; NADPH Oxidase; NR3C2; National Heart, Lung, and Blood Institute; Neonatal; Nuclear Receptor Subfamily 3 Group C Member 2; Oryctolagus cuniculus; Oxidation-Reduction; Oxygen Radicals; P47; Pathologic; Pathology; Pathway interactions; Patients; Peptidyl-Dipeptidase A; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Physiopathology; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Pro-Oxidants; Protein Isoforms; Proteins; RNA Expression; Rabbit, Domestic; Rabbits; Rat; Rattus; Reactive Oxygen Species; Receptor Signaling; Receptors, Epinephrine; Redox; Renin-Angiotensin-Aldosterone System; Reporting; Research Proposals; Role; Signal Transduction; Signal Transduction Systems; Signaling; Sodium Chloride; Sodium chloride (NaCl); Staging; Strategic Planning; Symptoms; System; System, LOINC Axis 4; System, Renin-Angiotensin-Aldosterone; Texas; Therapeutic Steroid Hormone; Time; Tissues; Transcription; Transcription, Genetic; United States; Universities; Up-Regulation; Up-Regulation (Physiology); Upregulation; Ventricular; Work; adenoreceptor; adrenergic; aldosterone inhibitor; balance; balance function; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; breast cancer nuclear receptor-binding auxiliary protein, human; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiomyocyte; cardiovascular disorder; clinical investigation; coronary attack; coronary infarct; coronary infarction; disability; drug/agent; extracellular; gene product; genetic disorder; heart attack; heart disorder; heart infarct; heart infarction; hereditary disorder; human AKAP13 protein; improved; in vivo; inhibitor; inhibitor/antagonist; insight; lymphoid blast crisis protein, human; methionine sulfoxide reductase; microtubule associated protein 2 kinase; molecular pathology; mouse model; new therapeutic target; novel; overexpression; oxidation; oxidation reduction reaction; pathophysiology; pathway; peptide methionine sulfoxide reductase; prevent; preventing; protein kinase II; protein structure function; response; salt; social role; steroid hormone; tool",Evaluating CaMKll as mediator of aldosterone-induced cardiac hypertophy,,95325,ZRG1,Special Emphasis Panel,,2,26794,
7753253,F30,NS,5,,02/01/2010,01/31/2011,PA-05-151,5F30NS057884-03,,NINDS:36482;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,GENETICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"ORENGO, JAMES P;",7761413;,5F30NS057884,02/01/2008,01/31/2011,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; 3' Untranslated Regions; 3'UTR; Address; Adult; Alternate Splicing; Alternative Splicing; Assay; Atrophy, Muscle; Bioassay; Biologic Assays; Biological Assay; Blotting, Western; Body Tissues; Breeding; CD34; CD34 gene; Cause of Death; Cell Culture Techniques; Cell Nucleus; Cerebellar Ataxia; Cerebellar Incoordination; Characteristics; Control Animal; DNA Recombination; DNA recombination (naturally occurring); Defect; Degenerative Disorder; Development; Disease; Disease Progression; Disorder; Dystrophia Myotonica; Electron Microscopy; Electrophoresis; Escalante syndrome; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Event; Exercise; Exercise, Physical; Exhibits; Fractionation, Electrophoretic; Fragile X; Fragile X Syndrome; Freidreich's Ataxia; Friedreich Ataxia; Friedreich Disease; Friedreich Spinocerebellar Ataxia; Friedreich's Familial Ataxia; Friedreich's Hereditary Ataxia; Friedreich's tabes; Gene Products, RNA; Gene Transcription; Genes; Genetic Recombination; Genetic Transcription; Goals; HPCA1; HUP1; Heart; Hereditary Spinal Ataxia, Friedreich's; Histology; Human, Adult; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; IGF1; IGF1 gene; IGFI; Individual; Injury; Insulin Resistance; Investigation; Lead; MR Imaging; MR Tomography; MRF4; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mice; Mice, Transgenic; Modeling; Molecular; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Fibers; Muscle Tissue; Muscle function; Muscle satellite cell; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Muscular Dystrophies; Myf-6; Myf-6 myogenic factor; Myocytes; Myodystrophica; Myodystrophy; Myogenin; Myotonia; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Myotubes; NMR Imaging; NMR Tomography; Natural regeneration; Nuclear; Nuclear Magnetic Resonance Imaging; Nucleotides; Nucleus; PAX7; PAX7 gene; PKC(alpha); PKCA; PRKCA; Paired Box Gene 7; Paired Box Homeotic Gene 7; Paired Domain Gene 7; Pathology; Pathway interactions; Patients; Pattern; Pb element; Phenotype; Phosphorylation; Play; Progressive Chorea, Hereditary, Chronic (Huntington); Proliferating; Protein Kinase C Alpha; Protein Kinase Calpha; Protein Phosphorylation; Proteins; RNA; RNA Expression; RNA Splicing; RNA Splicing, Alternative; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Recombination; Recombination, Genetic; Regeneration; Regulation; Renpenning syndrome 2; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyocyte; Ribonucleic Acid; Role; Sclerosis, Hereditary Spinal; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Spinal; Splicing; Steinert Disease; Symptoms; TAM; Tamoxifen; Testing; Tet; Tetanus Helper Peptide; Time; Tissues; Toxic effect; Toxicities; Transcription; Transcription, Genetic; Transgenes; Transgenic Animals; Transgenic Mice; Transgenic Organisms; UTRs; Untranslated Regions; Western Blotting; Western Blottings; Western Immunoblotting; Work; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; Zeugmatography; adult human (21+); autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; degenerative condition; degenerative disease; disease/disorder; family ataxia; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; gene product; heavy metal Pb; heavy metal lead; herculin; in vivo; injured; insight; insulin resistant; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; mar(X) syndrome; marker X syndrome; mental retardation-macroorchidism syndrome; mouse model; muscle degeneration; muscle regeneration; muscle regulatory factor 4; muscle stem cell; myogenic factor, Myf-6; novel; overexpression; pathway; postnatal; protein blotting; regenerate; regenerative; repair; repaired; response; reverse transcriptase PCR; satellite cell; social role; transgenic; wasting",Investigating mechanisms of skeletal muscle degeneration in Myotonic Dystrophy,,57884,ZNS1,Special Emphasis Panel,,3,36482,
7753256,F30,NS,5,,01/01/2010,12/31/2010,PA-05-151,5F30NS057899-03,,NINDS:46380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CAMBRIDGE,UNITED STATES,OTHER BASIC SCIENCES,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"HORNG, SAM H;",8138531;,5F30NS057899,01/01/2008,12/31/2010,"Age; Area striata; Area striata structure; Assay; Auditory; Autism; Autism, Early Infantile; Autism, Infantile; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome; Autistic Disorder; Axon; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cerebroatrophic Hyperammonemia; Cognition Disorders; Combining Site; Complementary DNA; Computer Programs; Computer software; Computing Methodologies; Cortex, Striate; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA, Complementary; Dandy-Walker Malformation; Dandy-Walker Syndrome; Dandy-Walker Syndrome, Familial; Dandy-Walker cyst; Dandy-Walker malformation (DWM); Dandy-Walker syndrome (DWS); Data; Development; Differential Gene Expression; Dorsal; EPH; Electroporation; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Eph Family Receptors; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Event; Family; Fellowship; Gene Expression; General Transcription Factor Gene; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, in situ Hybridization; Geniculate Bodies; Geniculate body structure; Holoprosencephaly; Human; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Intracellular Communication and Signaling; Kanner's Syndrome; Knockout Mice; Lateral Geniculate Body; Lead; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medial; Metathalamus; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microarray Analysis; Microarray-Based Analysis; Modality; Molecular; Murine; Mus; Mutation; Names; Neonatal; Nervous System Diseases; Nervous System, Brain; Neurodevelopmental Disorder; Neurologic Disorders; Neurological Development Disorder; Neurological Disorders; Nucleus; Null Mouse; PCR; Pathway interactions; Pattern; Pb element; Perinatal; Physiologic; Physiological; Play; Polymerase Chain Reaction; Primary visual cortex; Process; Proto-Oncogene, Transcription Factor; Reactive Site; Receptor Gene; Receptor Protein; Receptors, Eph Family; Regulation; Retina; Rett Disorder; Rett Syndrome; Rett syndrome (RS, RTS); Role; Schistorrhachis; Screening Result; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Software; Specificity; Spina Bifida; Spinal Dysraphia; Spinal Dysraphias; Spinal Dysraphism; Spinal Dysraphisms; Stimulus; Striate area; Synapses; Synaptic; Testing; Thalamic Nuclei; Thalamic structure; Thalamus; Time; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Transcription factor genes; Up-Regulation; Up-Regulation (Physiology); Upregulation; Visual; Visual Pathways; Visual System; Visual system structure; Work; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; area striata; atresia of the foramen of Luschka and Magendie; axon growth cone guidance; axon guidance; axonal pathfinding; biological signal transduction; cDNA; cell type; cleft spine; cognitive disease; cognitive disorder; computational methodology; computational methods; computer methods; computer program/software; experiment; experimental research; experimental study; extrastriate visual cortex; gain of function; geniculate nucleus; genome mutation; heavy metal Pb; heavy metal lead; hydrocele spinalis; in situ Hybridization Staining Method; in utero; insight; lateral geniculate; lateral geniculate nucleus; loss of function; member; microarray technology; nervous system disorder; neurological disease; novel; null mutation; optic imaging; optical imaging; overexpression; pathway; postnatal; rachischisis posterior; receptor; receptor expression; research study; retinogeniculate; social role; thalamic; transcription factor",Molecular Mechanisms of Visual Thalamic Development,,57899,ZNS1,Special Emphasis Panel,,3,46380,
7765621,F30,NS,5,,02/01/2010,01/31/2011,PA-05-151,5F30NS057901-04,,NINDS:46380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"VAISHNAVI, SANJEEV ;",8707174;,5F30NS057901,02/01/2007,01/31/2011,"ATP biosynthesis (oxidative); Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Analysis, Data; Apoplexy; Area; Blood flow; Brain; Brain imaging; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cognitive; Complex; Consumption; D-Glucose; Data Analyses; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dextrose; Disease; Disorder; Encephalon; Encephalons; Functional Imaging; Functional Magnetic Resonance Imaging; Glucose; Human; Human, General; Imaging Procedures; Imaging Techniques; Intermediary Metabolism; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Learning; METBL; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Metabolic; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear Magnetic Resonance Imaging; O element; O2 element; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxygen; Oxygen Consumption; PET; PET Scan; PET imaging; PETSCAN; PETT; Physiologic Imaging; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Senile Degenerative Dementia; Proton Magnetic Resonance Spectroscopic Imaging; R01 Mechanism; R01 Program; RPG; Rad.-PET; Regional Blood Flow; Reporting; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rest; Retrieval; Rotation; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stimulus; Stroke; Structure; Synapses; Synaptic; Task Performances; Technics, Imaging; Techniques; Testing; Vascular Accident, Brain; Visual; Zeugmatography; aerobic glycolysis; aging population; biological signal transduction; blood oxygen level dependent; brain attack; brain metabolism; brain visualization; cerebral vascular accident; clinical relevance; clinically relevant; dementia of the Alzheimer type; disease/disorder; experiment; experimental research; experimental study; fMRI; glucose metabolism; indexing; interest; interventional strategy; neuroimaging; neuronal; primary degenerative dementia; research study; senile dementia of the Alzheimer type; stroke; visual motor; visuomotor",Learning Related Modulation of Resting Brain Metabolism,,57901,ZNS1,Special Emphasis Panel,,4,46380,
7759200,F30,NS,5,,02/01/2010,01/31/2011,PA-05-151,5F30NS061409-03,,NINDS:28380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AURORA,UNITED STATES,PHYSIOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WRIGHT, MELISSA A.;",7812674;,5F30NS061409,02/01/2008,01/31/2011,"Action Potentials; Affect; Axon; Binding; Binding (Molecular Function); Brachydanio rerio; Cells; Connector Neuron; Danio rerio; Defect; Development; Developmental Process; Disease; Disorder; Dystonia; Embryo; Embryonic; Event; Fasciculation; Fasciculation, Muscular; Fasciculation, Neural; Gated Ion Channel; Generations; Genetics, in situ Hybridization; Glia; Glial Cells; Goals; Human; Human, General; In Situ Hybridization; Individual; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Ion Channels, Sodium; Kolliker's reticulum; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Messenger RNA; Mice; Microscopy; Molecular Interaction; Motor; Motor Cell; Motor Neurons; Msec; Murine; Mus; Muscle Dystonia; Muscle fasciculation; Nerve Degeneration; Neuroglia; Neuroglial Cells; Neuron Degeneration; Non-neuronal cell; Proteins; RNA, Messenger; Role; Sodium Channel; Spinal; Spinal Cord; Testing; Time; Translations; V (voltage); Zebra Danio; Zebra Fish; Zebrafish; disease/disorder; gene product; immunocytochemistry; in situ Hybridization Staining Method; knock-down; mRNA; millisecond; motoneuron; nerve cement; nervous system development; neural degeneration; neurodegeneration; neuronal degeneration; prevent; preventing; social role; voltage",Non-cell autonomous developmental effects of sodium channels,,61409,ZNS1,Special Emphasis Panel,,3,28380,
7761702,F30,NS,5,,02/01/2010,01/31/2011,PA-05-151,5F30NS062501-03,,NINDS:41380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"HAGEN, JOSHUA WAYNE;",9164315;,5F30NS062501,02/01/2008,01/31/2012,"Address; Assay; Bioassay; Biologic Assays; Biological Assay; Cancer Genes; Cancer-Promoting Gene; Cancers; Cell Function; Cell Growth and Maintenance; Cell Maintenance; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Complement; Complement Proteins; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disease Pathway; Disorder; Drosophila; Drosophila genus; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Embryonic Nervous System; Enhancers; Family; Fruit Fly, Drosophila; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Glia; Glial Cells; Human Pathology; In Vitro; Investigation; Knowledge; Kolliker's reticulum; Malignant Neoplasms; Malignant Tumor; Micro RNA; MicroRNAs; Modeling; Morphology; Mother Cells; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, CNS; Nervous system structure; Neural Cell; Neural Development; Neural Growth; Neural Stem Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neuronal Growth; Neurons; Non-neuronal cell; Oncogenes; Pattern; Phenotype; Play; Position; Positioning Attribute; Process; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Regulation; Role; Series; Signal Pathway; Small RNA; Stem Cell Development; Stem cells; Subcellular Process; Testing; Transcript; Transforming Genes; Work; base; disease/disorder; dosage; experiment; experimental research; experimental study; fruit fly; in vivo; insight; loss of function; malignancy; miRNA; mutant; neoplasm/cancer; nerve cement; nerve stem cell; neural; neural patterning; neural progenitor cells; neurodegenerative illness; neurodevelopment; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; relating to nervous system; research study; sensor; social role",Regulation of neural development by Drosophila microRNA-315.,,62501,ZNS1,Special Emphasis Panel,,3,41380,
7782814,F30,NS,5,,03/01/2010,02/28/2011,PA-05-151,5F30NS063630-02,,NINDS:29002;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW ORLEANS,UNITED STATES,OTHER BASIC SCIENCES,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"STARK, DAVID ;",9301126;,5F30NS063630,03/01/2009,02/28/2014,"15-LOX; 15-Lipoxygenase; 15-Lipoxygenase, Reticulocyte Arachidonate; ALOX15; ALOX15 gene; Action Potentials; Affect; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Arachidonate 15-Lipoxygenase; Arachidonate 15-Lipoxygenase Gene; Arachidonate Omega-6 Lipoxygenase; Arachidonate[{..}]oxygen 15-oxidoreductase; Arachidonic Acid 15-Lipoxygenase; Attenuated; BDNF; Bathing; Baths; Bioavailability; Biochemistry; Biologic Availability; Biological Availability; Biomedical Research; Blood Coagulation Factor IV; Brain; Brain-Derived Neurotrophic Factor; CRE Binding Protein; CREB; CREB Protein; Ca++ element; Calcium; Care, Health; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular biology; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chemistry, Biological; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Coagulation Factor IV; Cornu Ammonis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; DHA; DNA Molecular Biology; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Development; Disease; Disorder; Docosahexaenoic Acids; Docosahexenoic Acids; Dysfunction; Encephalon; Encephalons; Enzymes; Epilepsy; Epileptic Seizures; Epileptics; Equilibrium; Exhibits; Factor IV; Fluo-3; Functional disorder; Gene Expression; Genes; Genes, Overlapping; HPLC; Healthcare; High Pressure Liquid Chromatography; Hippocampus; Hippocampus (Brain); Human; Human, General; Image; In Vitro; Injury; Intracellular Communication and Signaling; Ischemia; LOG15 Gene; Life; Link; Lipids; Lipoxygenase 1; MGC34632; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Mitochondria; Modeling; Molecular; Molecular Biology; Molecular and Cellular Biology; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Necrosis; Necrotic; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Outcome; Overlapping Genes; Pathology; Pathway interactions; Patients; Physiologic; Physiologic Availability; Physiological; Physiopathology; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Receptor Signaling; Receptors, N-Methylaspartate; Regulation; Reperfusion Therapy; Research; Retinal; Role; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Stroke; Synapses; Synaptic; Techniques; Testing; Touch; Touch sensation; Toxic effect; Toxicities; Vascular Accident, Brain; Wild Type Mouse; balance; balance function; base; bioavailability of drug; biological signal transduction; brain attack; brain cell; burden of care; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; care burden; cell biology; cerebral vascular accident; dementia of the Alzheimer type; disease/disorder; epilepsia; epileptiform; epileptogenic; excitotoxicity; experiment; experimental research; experimental study; hippocampal; imaging; improved; in vivo; lipid mediator; mitochondrial; mitochondrial dysfunction; necrocytosis; neurodegenerative illness; neuronal; neuronal survival; neuroprotectin D1; neuroprotection; novel; pathophysiology; pathway; primary degenerative dementia; programs; public health relevance; reperfusion; research study; response; senile dementia of the Alzheimer type; social role; stroke; tandem mass spectrometry",Regulation of Neuroprotective Lipid Sgnals by Spatially Distinct NMDA Receptors,,63630,NST,Training Grant and Career Development Review Committee,,2,29002,
7736792,F31,AG,5,,02/01/2010,01/31/2011,PA-07-002,5F31AG032806-02,,NIA:30060;,2010,NATIONAL INSTITUTE ON AGING,,NEW BRUNSWICK,UNITED STATES,BIOLOGY,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"SON, ALEXANDER INHA;",9298232;,5F31AG032806,02/01/2009,01/31/2013,"AL-1; AL-1 Protein; ATP[{..}]protein-tyrosine O-phosphotransferase; Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Affect; Age; Anchoring Junction; Blindness; Body Tissues; Cancers; Cataract; Cell Communication; Cell Interaction; Cell Nucleus; Cell Shape; Cell-Cell Adhesion; Cell-to-Cell Interaction; Cells; Characteristics; Complex; Constitution; Deterioration; Development; Disease; Disorder; EC 2.7; EPH; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Environmental Factor; Environmental Risk Factor; Eph Family Receptors; Eph Receptor Tyrosine Kinase; Eph Receptors; EphA8 Protein; Ephrin Receptors; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Ephrin-A5; Epithelial Cells; Eye; Eyeball; Family; Future; Genetic; HEK3; Human; Human, General; Individual; Interruption; Kinases; Knowledge; LERK-7 Protein; Learning; Lens Fiber; Ligands; Light; Location; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Molecular; Murine; Mus; N-Cadherin; Nucleus; Organelles; PTK; Pattern; Penetration; Phosphotransferases; Photoradiation; Play; Prevention; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Public Health; RAGS Protein; REK7 Ligand AL-1; Receptor Protein; Receptors, Eph Family; Regulation; Repulsive Axon Guidance Signal Protein; Retina; Role; Sight; Signaling Molecule; Structure; Testing; Time; Tissues; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vision; axonal guidance; cataractogenesis; cataractous lenses; disease/disorder; environmental risk; experiment; experimental research; experimental study; fiber cell; gene product; hydroxyaryl protein kinase; insight; lens; lens transparency; light transmission; malformation; malignancy; member; mutant; neoplasm/cancer; novel; public health medicine (field); receptor; research study; social role; tyrosyl protein kinase",ROLE OF EPHRIN-A5 IN LENS FIBER CELL ORGANIZATION,,32806,ZRG1,Special Emphasis Panel,,2,30060,
7762829,F31,AI,5,,03/01/2010,02/28/2011,PA-07-106,5F31AI078700-03,,NIAID:41176;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WINSTON-SALEM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"BYRD, MATTHEW ;",9201170;,5F31AI078700,03/01/2008,02/29/2012,"Active Oxygen; Acute; Address; Affect; Alginates; American; Animal Model; Animal Models and Related Studies; Animals; Antibiotic Resistance; Antibiotic Therapy; Antibiotic Treatment; Antibodies; Antimicrobial Resistance; Antimicrobial resistant; Arabinose; Assay; Bacteria; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Blood leukocyte; Body Tissues; CF patients; Cell Communication and Signaling; Cell Signaling; Cell surface; Cells; Characteristics; Chemiluminescence Measurements; Chemiluminescence assay; Chemiluminescent Assays; Chemiluminescent Measurements; Chemoluminescence Measurements; Chinchilla; Chinchilla (genus); Chronic; Communities; Complement; Complement Proteins; Cytoplasmic Granules; Data; Deposit; Deposition; Diagnosis; Enzymes; FLR; Failure (biologic function); Gamma Globulin, 7S; Genetic; Glycans; Gram-Negative Bacteria; Heterophil Granulocyte; Histology; Hospital Infections; Hospital acquired infection; Human; Human, General; IgG; Immune; Immune response; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin G; Infection; Intracellular Communication and Signaling; Killings; Knowledge; L-Arabinose; Lead; Leukocytes; Link; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Mediating; Mice; Microbial Biofilms; Mission; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nosocomial Infections; Otitis; Oxidative Burst; Oxygen Radicals; P. aeruginosa; P.aeruginosa; Pathogenesis; Pathology; Patients; Pattern; Pb element; Phagocytosis; Polymers; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Polysaccharides; Predisposition; Pro-Oxidants; Process; Production; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Reactive Oxygen Species; Research; Resistance; Resistance to antibiotics; Resistance to antimicrobial; Resistance, Antibiotic; Resistant to antibiotics; Respiratory Burst; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Role; Sampling; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Structure; Surface; Susceptibility; Testing; Therapeutic; Time; Tissues; United States National Institutes of Health; Virulence; White Blood Cells; White Cell; anti-microbial; anti-microbial resistance; anti-microbial resistant; antibiotic resistant; antimicrobial; antimicrobial peptide; biofilm; biological signal transduction; body system, allergic/immunologic; burden of disease; burden of illness; cystic fibrosis patients; design; designing; disease burden; experiment; experimental research; experimental study; extracellular; failure; granule; heavy metal Pb; heavy metal lead; host response; immunoresponse; in vivo; in vivo Model; institutional infection; leukocyte oxidative burst; model organism; mucoid; mutant; neutrophil; organ system, allergic/immunologic; overexpression; pathogen; pathogenic bacteria; patients with CF; patients with cystic fibrosis; prevent; preventing; pulmonary; research study; resistance to anti-microbial; resistant; resistant to anti-microbial; resistant to antimicrobial; respiratory; respiratory burst (leukocyte); response; social role; treatment of bacterial diseases; treatment of bacterial infectious disease; treatment strategy; white blood cell; white blood corpuscle; years of life lost to disability; years of life lost to disease",The role of exopolysaccharides in Pseudomonas aeruginosa virulence,,78700,ZRG1,Special Emphasis Panel,,3,41176,
7795943,F31,AI,5,,02/01/2010,01/31/2011,PA-07-106,5F31AI078716-02,,NIAID:28413;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,PEDIATRICS,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SAENZ, JOSE BERNARDO;",9177814;,5F31AI078716,02/01/2009,01/31/2011,"4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-; ADP-Ribosylation Factor 1; ARF 1 Protein; ARF1 Protein; ARF1p; ATP-protein phosphotransferase; Ascotoxin; Assay; Autoregulation; Bacterial Toxins; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Terrorism; Bioterrorism; Brefeldin A; Bypass; Cells; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Complex; Cyanein; Cytosol; Decumbin; Destinations; Disease; Disorder; EC 2.7; Endocytosis; Endoplasmic Reticulum; Endosomes; Equilibrium; Ergastoplasm; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GTP GDP exchange factor; Genetic; Golgi; Golgi Apparatus; Golgi Complex; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; High Throughput Assay; Homeostasis; Human; Human, General; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Immunologic, Luciferase; Intoxication; Intracellular Transport; Isoforms; Kinases; Lectin, Castor Bean; Lectin, Ricinus; Libraries; Luciferases; Lytotoxicity; Man (Taxonomy); Man, Modern; Maps; Mediating; Membrane; Methods; Molecular Interaction; Monitor; Organelles; Pathway interactions; Phosphotransferases; Physiological Homeostasis; Plants; Plants, General; Protein Isoforms; Protein Kinase; Protein Synthesis Inhibition; RCA 60; RCA60; RNA, Small Interfering; Radioactive; Receptosomes; Ricin; Ricinus Communis Agglutinin II; Ricinus Toxin; Role; Route; Shiga Toxin; Shigella Cytotoxin; Shigella Toxin; Site; Small Interfering RNA; Specificity; Staging; Structure-Activity Relationship; Stx Protein; Stx Protein, Shigella dysenteria; Synergisidin; System; System, LOINC Axis 4; Targeted Toxins; Therapeutic; Toxin; Toxins, Targeted; Translating; Translatings; Transphosphorylases; VESCL; Vesicle; Virulence; balance; balance function; base; chemical structure function; cytotoxicity; disease/disorder; exchange factor; glycogen synthase a kinase; high throughput screening; human disease; hydroxyalkyl protein kinase; inhibitor; inhibitor/antagonist; kinase inhibitor; knock-down; language translation; membrane structure; mutant; novel; pathway; pharmacophore; phosphorylase b kinase kinase; retrograde transport; siRNA; small molecule; small molecule libraries; social role; structure function relationship; tool; trafficking",A Small Molecule Approach Toward Understanding Bacterial Toxin Transport,,78716,ZRG1,Special Emphasis Panel,,2,28413,
7776947,F31,AI,5,,02/16/2010,02/15/2011,PA-07-106,5F31AI080230-02,,NIAID:27362;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PROVIDENCE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,001785542,US,RI,02912,BROWN UNIVERSITY,"BANH, CINDY ;",9287214;,5F31AI080230,02/16/2009,02/15/2012,"Activated Natural Killer Cell; Adhesion Molecule; Affect; Binding; Binding (Molecular Function); Biochemical; Body Tissues; CAM 120/80; CD8; CD8B; CD8B1; CD8B1 gene; Cadherin-1; Cadherins; Cancers; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Communicable Diseases; Complex; Cytotoxic cell; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; E-Cadherin; Endocytosis; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial Cells; Epithelial-Cadherin; Generations; Immune; Immune response; Immune system; Immunologic Receptors; Immunological Receptors; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intracellular Communication and Signaling; K Cells; K lymphocyte; Killer Cells; Knowledge; L-Serine; L-Threonine; LYT3; Laboratories; Lectin; Ligands; Liver Cell Adhesion Molecules; Location; Lymphocyte; Lymphocytic; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Mediating; Methods and Techniques; Methods, Other; Mice; Modification; Molecular; Molecular Interaction; Murine; Mus; NK Cell Activation; NK Cells; Natural Killer Cell Activation; Natural Killer Cells; Nervous; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Receptor Protein; Receptors, Immunologic; Recruitment Activity; Regulation; Research; Role; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; Surface; T-Cells; T-Lymphocyte; Techniques; Threonine; Thymus-Dependent Lymphocytes; Tissues; Transgenes; Tyrosine Phosphorylation; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Uvomorulin; Viral Diseases; Virus Diseases; biological signal transduction; body system, allergic/immunologic; cell adhesion protein; cell biology; cytotoxic; design; designing; experiment; experimental research; experimental study; gene product; host response; immune receptor; immunoresponse; in vivo; insight; liver cell adhesion molecule; lymph cell; malignancy; neoplasm/cancer; neural; organ system, allergic/immunologic; pathogen; public health relevance; receptor; recruit; relating to nervous system; research study; social role; thymus derived lymphocyte; tumor; ubiquination; ubiquitin conjugation; viral infection; virus infection","KLRG1, Cadherins and their interactions",,80230,ZRG1,Special Emphasis Panel,,2,27362,
7807917,F31,AI,5,,02/05/2010,02/04/2011,PA-07-106,5F31AI081524-02,,NIAID:41380;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,ANATOMY/CELL BIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"MARTINEZ, NATHANIEL W.;",9466277;,5F31AI081524,02/05/2009,02/04/2011,"AIDS Virus; Cellular Membrane; Cytoplasm; Development; Family; Gagging; Gene Products, gag; Goals; HIV Infections; HIV-1; HIV-I; HIV1; HTLV-III Infections; HTLV-III-LAV Infections; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Kinesin; Motor; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Proteins; Reflex, Pharyngeal; Research; Retroviral Antigen gag Protein; Role; Staging; T-Lymphotropic Virus Type III Infections, Human; Viral gag Proteins; Virion; Virus Particle; gag Antigens; gag Gene Products; gag Polyproteins; gag Protein; gene product; group specific antigen; human T cell leukemia virus III; human T lymphotropic virus III; inhibitor; inhibitor/antagonist; novel; social role; trafficking","KIF4 motor protein, regulates trafficking and stability of HIV-1 Gag",,81524,ZRG1,Special Emphasis Panel,,2,41380,
7759614,F31,AT,5,,03/01/2010,02/28/2011,PAR-00-023,5F31AT004548-03,,NCCAM:27064;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,NEW YORK,UNITED STATES,BIOLOGY,17,620128301,US,NY,10468,HERBERT H. LEHMAN COLLEGE,"KELLER, AMY CELESTE;",8965405;,5F31AT004548,03/01/2008,02/28/2011,"5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; Active Follow-up; Affect; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Glucose; Blood Plasma; Blood Sugar; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular Expansion; Cellular Growth; Chemical Structure; Chronic Disease; Chronic Illness; Collection; Common Rat Strains; Communities; Complementary and alternative medicine; Cucurbitaceae; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Diagnosis; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disorder; Dominican; Drugs; Fruit; Goals; Gourd, Bitter; Herbal Medicine; Hispanic Populations; Hispanics; Hispanics or Latinos; Human; Human, General; Humulin R; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Hypoglycemic Drugs; Hypoglycemics; IDD; IDDM; Imidodicarbonimidic diamide, N,N-dimethyl-; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Juice; Karela; Latino Population; Left; MODY; Mammals, Rats; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measures; Medical; Medication; Medicinal Plants; Medicine; Medicine, Herbal; Metformin; Methods; Methods and Techniques; Methods, Other; Modeling; Momordica charantia; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIDDM; Non-Hispanic; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Novolin R; Obesity; Oral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phytochemical; Pioglitazone; Plants; Plants, General; Plants, Medicinal; Plasma; Population; Rat; Rattus; Research; Research Technics; Reticuloendothelial System, Serum, Plasma; Rodent Model; Science of Medicine; Serum, Plasma; Spanish Origin; T1 diabetes; T1D; T1DM; T2D; T2DM; Techniques; Techniques, Research; Testing; Training; Type 1 diabetes; Type 2 diabetes; Type II diabetes; United States; WHBLOOD; Whole Blood; adiposity; adult onset diabetes; anti-diabetic drugs; antidiabetic; antihyperglycemic; base; career; cell growth; chronic disease/disorder; chronic disorder; corpulence; corpulency; corpulentia; cultured cell line; diabetes; diabetic; dietary fruit; disease/disorder; drug/agent; follow-up; hispanic community; hyperglycemic; hypoglycemic; hypoglycemic episodes; improved; in vitro Assay; in vitro activity; in vitro testing; in vivo; insulin dependent diabetes; insulin secretion; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; maturity onset diabetes; mouse model; obese; obese people; obese person; obese population; skills; stem; type I diabetes",Antidiabetic Constituents from the Dominican Medicinal Plant Momordica charantia,,4548,ZAT1,Special Emphasis Panel,,3,27064,
7743843,F31,CA,5,,12/01/2009,11/30/2010,PA-07-106,5F31CA130144-03,,NCI:37380;,2010,NATIONAL CANCER INSTITUTE,,ITHACA,UNITED STATES,NUTRITION,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"REY, DIEGO A;",8844139;,5F31CA130144,12/01/2007,11/30/2010,"A33; ATGN; Abscission; Animals; Antibodies; Antibody Repertoire; Antigens; Area; Attention; Biologic Sciences; Biological; Biological Preservation; Biological Sciences; Biomedical Technology; Body Tissues; CCD camera; Cancer Intervention; Cancer Treatment; Cancerous; Cancers; Carcinoma Cell; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chemistry; Clinic; Collaborations; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Colorectal Cancer; Complement; Complement Proteins; Contrast Agent; Contrast Drugs; Contrast Media; Development; Diagnosis; Diagnostic; Early Diagnosis; Electron Microscopy; Encapsulated; Engineering; Engineerings; Equilibrium; Excision; Extirpation; Fluorescence Spectroscopy; Foundations; Future; GPA33; GPA33 gene; Generations; Glass; Goals; Human; Human, General; Hydrogen Oxide; Image; Image Analyses; Image Analysis; Imaging Device; Imaging Tool; Incubated; Intervention; Intervention Strategies; Label; Laboratories; Life Sciences; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Membrane Proteins; Membrane-Associated Proteins; Methods; Mission; Modification; NCI; NCI Organization; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; Oleic Acids; Operation; Operative Procedures; Operative Surgical Procedures; Organic Solvents; Organic solvent product; Patients; Penetration; Physicians; Position; Positioning Attribute; Preservation, Biologic; Preservation, Biological; Q-Dot; Quantum Dots; ROC Analysis; Radiation, Visible; Radiation, Visible Light; Radiopaque Media; Reagent; Removal; Research; Resolution; Science of Chemistry; Sensitivity and Specificity; Site; Spectroscopy, Fluorescence; Speed; Speed (motion); Staging; Structure; Surface Proteins; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Testing; Therapeutic; Time; Tissues; Tumor Antigens; Tumor Cell; Tumor-Associated Antigen; UV laboratory microscope; Ultraviolet Microscopes; Visible Light; Visible Radiation; Water; Work; anticancer therapy; balance; balance function; base; cancer diagnosis; cancer imaging; cancer therapy; charge coupled device camera; colon cancer cell line; copolymer; cross-link; crosslink; cultured cell line; design; designing; detector; early detection; experiment; experimental research; experimental study; fluorescence microscope; fluorescence/UV microscope; fluorescent microscope; image evaluation; image guided intervention; image guided therapy; imaging; imaging probe; immunogen; infrared microscopy; interventional strategy; laboratory fluorescence light microscope; lead sulfide; malignancy; metastatic colorectal; minimally invasive; nano meter scale; nano meter sized; nano particle; nano scale; nanometer scale; nanometer sized; nanoparticle; nanoscale; neoplasm/cancer; neoplastic cell; optic imaging; optical imaging; preempt; preservation; research study; resection; success; surgery; tool; tool development; tumor-specific antigen",Targeted Near-Infrared Probes for Image-Guided Cancer Interventions,,130144,ZRG1,Special Emphasis Panel,,3,37380,
7749991,F31,CA,5,,12/01/2009,11/30/2010,PA-07-106,5F31CA132613-03,,NCI:33913;,2010,NATIONAL CANCER INSTITUTE,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"MALDONADO, ARTURO RAFAEL;",9021143;,5F31CA132613,12/01/2007,11/30/2010,"0-11 years old; Adenocarcinoma Cell; Age; Attenuated; Automobile Driving; Body Tissues; Cancer Treatment; Cancers; Cardiac Diseases; Cardiac Disorders; Cause of Death; Cells; Cephalic; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Cranial; Cytolysis; Development; Drivings, Automobile; Engineering; Engineerings; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes, Viral; Genetic Intervention; HHV-1; HSV; HSV vector; HSV-1; HSV1; Heart Diseases; Heparin Binding Growth Factor; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes Simplex Virus Vector; Herpes labialis Virus; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus hominis; Human; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; Human, Child; Human, General; Hypoxia; Hypoxic; Intervention, Genetic; Investigators; Ischemia; Killings; Lysis; MPNST; Malignant; Malignant - descriptor; Malignant Cell; Malignant Glandular Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Peripheral Nerve Sheath Tumor; Malignant Schwannoma; Malignant Tumor; Man (Taxonomy); Man, Modern; Moab, Clinical Treatment; Molecular; Molecular Biology, Gene Therapy; Monoclonal Antibodies; Mortality; Mortality Vital Statistics; Multiple Neurofibromas; Nerve Sheath Tumors, Peripheral; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurofibromatoses; Neurofibromatosis; Neurofibromatosis Syndrome; Normal Cell; Normal Tissue; Normal tissue morphology; Oncolytic; Oncolytic viruses; Oxygen Deficiency; PTK Inhibitors; Patients; Peripheral Nerve Sheath Neoplasm; Phosphorylation; Play; Poisons; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Protein Tyrosine Kinase Inhibitors; Proteins; Research; Research Personnel; Researchers; Role; Scientist; Simplexvirus; Solid Neoplasm; Solid Tumor; Specificity; TK Inhibitors; Testing; Therapeutic; Therapy, DNA; Tissues; Toxic Chemical; Toxic Substance; Toxic effect; Toxicities; Transgenes; Translational Research; Translational Research Enterprise; Translational Science; Translations; Tumor Cell; Tyrosine Kinase Inhibitor; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral; Viral Genes; Virus; Virus Replication; Viruses, General; Xenograft Model; anti-cancer therapeutic; anticancer therapeutic; anticancer therapy; attenuation; base; cancer cell; cancer therapy; children; clinical investigation; cytokine MK; design; designing; driving; gene product; gene therapy; genetic therapy; heart disorder; herpes simplex i; herpes virus 1, human; herpesvirus; human alphaherpesvirus 1; human herpesvirus 1 group; malignancy; midkine; mutant; neoplasm/cancer; neoplastic cell; neurovirulence; new therapeutic target; new therapeutics; next generation; next generation therapeutics; novel; novel therapeutics; oncolysis; poison; pre-clinical; preclinical; preclinical study; prevent; preventing; selective expression; selectively expressed; social role; toxic compound; translation research enterprise; tumor; vector; virus multiplication; youngster",Targeting Oncolytic HSV to Neuroblastoma & Malig. Peripheral Nerve Sheath Tumors,,132613,ZRG1,Special Emphasis Panel,,3,33913,
7751845,F31,CA,5,,01/01/2010,12/31/2010,PA-07-106,5F31CA132619-03,,NCI:36828;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,OTHER BASIC SCIENCES,01,042084434,US,IL,606163793,ILLINOIS INSTITUTE OF TECHNOLOGY,"ALIMIRAH, FATOUMA ;",8963067;,5F31CA132619,01/01/2008,12/31/2011,"1 alpha,25-Dihydroxycholecalciferol; 1 alpha,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol; 1,25-Dihydroxycholecalciferol Receptors; 1,25-Dihydroxyvitamin D3; 1,25-Dihydroxyvitamin D3 Receptors; 3' Untranslated Regions; 3'UTR; 5'-Adenylic acid, homopolymer; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-; African; African American; Afro American; Afroamerican; Age; Alleles; Allelomorphs; American Cancer Society; Apoptosis; Apoptosis Pathway; Apoptotic; Asians; Assay; Athymic Nude Mouse; Bioassay; Biologic Assays; Biological Assay; Black Populations; Black or African American; Breast Cancer Cell; Breast Carcinoma; Calcitriol; Cancer of Breast; Cancers; Carcinoma Cell; Case Study; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell Communication and Signaling; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cholecalciferol Receptors; Data; Development; Disease; Disease-Free Survival; Disorder; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Estrogen Receptors; Event-Free Survival; Exons; Gene variant; Generalized Growth; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Growth; Hispanic Populations; Hispanics; Hispanics or Latinos; Human; Human Breast Cancer Cell; Human, General; Hypercalcemia; Immunologic, Luciferase; In Vitro; Incidence; Intracellular Communication and Signaling; Laboratories; Latino Population; Length; Link; Luciferases; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Mediating; Mice, Athymic; Mice, Nude; Molecular; Mortality; Mortality Vital Statistics; Nude Mice; Occidental; Patients; Pattern; Poly A; Poly(rA); Polymorphism (Genetics); Polymorphism, Genetic; Receptor Gene; Receptors, 1,25-Dihydroxyvitamin D 3; Receptors, Calcitriol; Reporting; Retrospective Studies; Risk; Role; Signal Transduction; Signal Transduction Systems; Signaling; Spanish Origin; Survival Rate; Tissue Growth; Toxic effect; Toxicities; VDR; VIT D; Variant; Variation; Variation (Genetics); Vitamin D; Vitamin D 3 Receptors; Vitamin D Analog; Vitamin D Receptors; Vitamin D3 Receptor; Woman; Xenograft Model; adenylate; allelic variant; analog; biological signal transduction; black American; cancer initiation; cancer risk; cancer type; case report; cell growth; cultured cell line; disease risk; disease/disorder; disorder risk; experiment; experimental research; experimental study; hispanic community; malignancy; malignant breast neoplasm; neoplasm/cancer; ontogeny; oriental; polyadenylate; polymorphism; population based; research study; response; social role; white race",Role of Vitamin D Receptor Polymorphisms in Breast Cancer,,132619,ZRG1,Special Emphasis Panel,,3,36828,
7753585,F31,CA,5,,12/01/2009,11/30/2010,PA-07-106,5F31CA136180-02,,NCI:28524;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,PATHOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"RAMOS, ALEXIS HIRAM;",9313700;,5F31CA136180,12/01/2008,11/30/2011,"Accounting; Anchorage-Independent Growth; Assay; BCR-ABL; BCR-ABL Oncoprotein; BCR-ABL Protein Tyrosine Kinase; BCR/ABL; Biliary or Urinary Stones; Bioassay; Biologic Assays; Biological Assay; Calculi; Cancer Cause; Cancer Etiology; Cancer Patient; Cancer Treatment; Cancer of Lung; Cancer of Prostate; Cancers; Carcinoma Cell; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Line; Cell Lines, Strains; CellLine; Complementary DNA; DNA; DNA Resequencing; DNA Sequence Analysis; DNA, Complementary; Data; Deoxyribonucleic Acid; Dideoxy Chain Termination DNA Sequencing; Drug Therapy; EC 2.7; Epidermoid Cell Lung Carcinoma; Epithelial; Expression Profiling; Expression Signature; Frequencies (time pattern); Frequency; Fusion Proteins, bcr-abl; Future; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genomics; Goals; Imatinib; In Vitro; Kinases; Lead; Lung; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Prostate; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant prostatic tumor; Methods and Techniques; Methods, Other; Micro RNA; MicroRNAs; Modeling; Molecular Fingerprinting; Molecular Profiling; Mutate; Mutation; Mutation Spectra; NIH 3T3 Cells; NIH/3T3; Oncogenesis; Pathogenesis; Patients; Pb element; Pharmacotherapy; Phosphotransferases; Play; Point Mutation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prostate CA; Prostate Cancer; Prostatic Cancer; Pulmonary Cancer; Pulmonary malignant Neoplasm; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Resequencing; Respiratory System, Lung; Role; Sampling; Sanger Sequencing; Sequence Analyses, DNA; Sequence Analysis, DNA; Sequence-Specific Posttranscriptional Gene Silencing; Shotgun Sequencing; Somatic Mutation; Squamous Cell Epithelioma; Squamous Cell Lung Carcinoma; Squamous cell carcinoma; Stone; Techniques; Technology; Testing; Transphosphorylases; anticancer therapy; bcr-abl Fusion Proteins; cDNA; cancer therapy; cultured cell line; experiment; experimental research; experimental study; fusion gene; genome mutation; heavy metal Pb; heavy metal lead; interest; lung cancer; malignancy; miRNA; molecuar profile; molecular signature; mutant; neoplasm/cancer; novel; overexpression; pulmonary; research study; shRNA; short hairpin RNA; small hairpin RNA; social role; tumor; tumorigenesis; tumorigenic",Somatic Mutation Discovery in Lung Squamous Cell Carcinoma,,136180,ZRG1,Special Emphasis Panel,,2,28524,
7802829,F31,CA,5,,12/01/2009,11/30/2010,PA-07-106,5F31CA136322-03,,NCI:32834;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,NONE,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"CLOWER, CYNTHIA ;",9308447;,5F31CA136322,12/01/2008,11/30/2012,"21+ years old; Accounting; Adult; Alternate Splicing; Alternative Splicing; Anaplastic; Body Tissues; Cancer cell line; Cancers; Cells; Clinic; Custom; Development; Enzymes; Exhibits; Exons; Expression Profiling; Expression Signature; Fluorescence; Gene Expression; Generalized Growth; Generations; Genes; Glycolysis; Growth; Human, Adult; Hypoxia; Hypoxic; Intermediary Metabolism; Isoenzymes; Isoforms; Isozymes; Laboratories; Lead; Libraries; METBL; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic; Metabolic Processes; Metabolism; Mitochondria; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Monitor; Normal Cell; O element; O2 element; Oligomycins; Oncogenesis; Oxygen; Oxygen Deficiency; Pathway interactions; Pb element; Phenotype; Process; Protein Isoforms; Pyruvate Kinase; RNA Splicing; RNA Splicing, Alternative; Reaction; Regulation; Reliance; Reporter; Respiration; Role; Splicing; Staging; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Tissues; Tumor Cell; Tumorigenicity; Undifferentiated; Validation; Variant; Variation; Warburg Effect; Work; adult human (21+); cancer cell; fetal; genome, mammalian; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; insight; loss of function; malignancy; mammalian genome; mitochondrial; molecuar profile; molecular signature; neoplasm/cancer; neoplastic cell; novel therapeutic intervention; ontogeny; pathway; phosphoenol transphosphorylase; phosphoenolpyruvate kinase; respiratory mechanism; shRNA; short hairpin RNA; small hairpin RNA; social role; tool; tumor; tumorigenesis; tumorigenic",Alternative Splicing of Pyruvate Kinase M: Regulation and Significance in Cancer,,136322,ZRG1,Special Emphasis Panel,,3,32834,
7748920,F31,CA,5,,12/01/2009,11/30/2010,PA-07-106,5F31CA138097-02,,NCI:30049;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,PATHOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"FARMER, REBECCA LEIGH;",8476596;,5F31CA138097,12/01/2008,11/30/2011,"4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Adverse effects; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biological Factors; Biological Testing; Cancer Cause; Cancer Etiology; Cancer Model; Cancer Treatment; Cancer of Prostate; CancerModel; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cause of Death; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cessation of life; Chemicals; Chronic; Data; Death; Development; Disease; Disorder; Drug Kinetics; EC 2.7; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Estrogen Receptors; Estrogen Therapy; Event; Exhibits; Factor, Biologic; Family; Gene Expression; Generalized Growth; Genestein; Genistein; Genisteol; Genital System, Male, Prostate; Goals; Growth; Gynecomastia; Hot flushes; Human; Human Prostate; Human Prostate Gland; Human, General; In Vitro; Intracellular Communication and Signaling; Isoflavones; Kinases; Laboratories; Lead; Left; Life; MAP Kinase Signaling Pathways; Male Breast Enlargement; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Modification; Molecular; Molecular Interaction; Mortality; Mortality Vital Statistics; Murine; Mus; Natural Products; Neoplasm Metastasis; Organ System, Cardiovascular; PC3 cell line; Pb element; Pharmacokinetics; Phosphotransferases; Phyto-Estrogen; Phytoestrogens; Population; Primary Neoplasm; Primary Tumor; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Prunetol; Public Health; Reporter; Reporting; Research; Screening procedure; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Structure; Structure-Activity Relationship; Testing; Therapeutic; Therapeutic Intervention; Tissue Growth; Toxic effect; Toxicities; Transphosphorylases; Treatment Side Effects; Tumor Cell; Tumor Cell Migration; United States; Vascular, Heart; anticancer therapy; base; biological signal transduction; cancer cell; cancer metastasis; cancer therapy; cell growth; chemical structure function; chiral molecule; circulatory system; cultured cell line; design; designing; disease/disorder; estrogenic activity; farmer; flavanoid; functional group; heavy metal Pb; heavy metal lead; hot flash; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; isoflavanone; male; man; man's; member; men; men's; mitogen-activated protein kinase p38; neoplastic cell; novel; ontogeny; p38 MAP Kinase; p38 MAPK; p38 Protein Kinase; p38 SAPK; prostate cancer cell line; public health medicine (field); scaffold; scaffolding; screening; screenings; side effect; southeast Asian; soy; structure function relationship; therapy adverse effect; treatment adverse effect",Molecular Inhibitors of Prostate Cancer Metastasis,,138097,ZRG1,Special Emphasis Panel,,2,30049,
7751339,F31,DA,5,,01/01/2010,12/31/2010,PA-04-032,5F31DA021040-03,,NIDA:36308;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,EAST LANSING,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"BOHNERT, KIPLING M;",8310711;,5F31DA021040,01/01/2008,12/31/2011,"6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-; 9-ene-Tetrahydrocannabinol; Accounting; Addiction, Drug; Assay; Behavior; Bioassay; Biologic Assays; Biological Assay; Cannabis; Cereals; Check-up; Chemical Dependence; DNA; Data; Delta-9-Tetrahydrocannabinol; Deoxyribonucleic Acid; Dependence; Dependence, Cannabis; Dependence, Drug; Development; Dronabinol; Drug Addiction; Drug Dependency; Early treatment; Epidemiology; Ethnic Origin; Ethnicity; Ethnicity aspects; Feedback; Fellowship; Female; Future; Gene variant; Genetic Diversity; Genetic Materials; Genetic Variation; Genetics, Other; Goals; Grain; Head and Neck, Saliva; Hemp Plant; Incentives; Individual; Internet; Intervention; Intervention Strategies; Investigators; Learning; Longitudinal Studies; Longitudinal Surveys; Marihuana; Marijuana Dependence; Marinol; Materials, Genetic; Models, Statistical; Monitor; NIDA; NRSA; Names; National Institute of Drug Abuse; National Research Service Awards; On-Line Systems; Online Systems; Other Genetics; Outcome; Participant; Patient Self-Report; Phase; Population; Prevention; Principal Investigator; Probabilistic Models; Process; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Public Health; R01 Mechanism; R01 Program; RPG; Race; Racial Group; Randomized; Reporting; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Specimen; Researchers; Respondent; Saliva; Salivary; Secure; Self-Report; Specimen; Staging; Statistical Models; Stocks, Racial; Stratification; Study Type; Surveys, Longitudinal; Test Result; Testing; Tetrahydrocannabinol; Treatment outcome; Variation (Genetics); WWW; adult youth; allelic variant; career; checkup; checkup examination; clinical significance; clinically significant; college student; cost; delta(1)-THC; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; drug detection; drug testing; gene product; incentive; inducement; innovate; innovation; innovative; intervention program; interventional strategy; long-term study; male; member; novel; online computer; pre-doc; pre-doctoral; predoc; predoctoral; programs; public health medicine (field); randomisation; randomization; randomized trial; randomly assigned; response; sample collection; specimen collection; stem; study design; tool; university student; web; web based; world wide web; young adult",Epidemiology & Experimental Interventions: NIDA Research,,21040,NIDA,Neuropharmacology Research Subcommittee,,3,36308,
7754030,F31,DA,5,,01/01/2010,12/31/2010,PA-07-002,5F31DA023315-03,,NIDA:27307;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HERSHEY,UNITED STATES,NEUROSCIENCES,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"PUHL, MATTHEW D;",8741265;,5F31DA023315,01/01/2008,12/31/2010,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Acute; Affect; American; Attention; Bed Nucleus of Stria Terminalis; Behavior; Blood Plasma; Brain; Chemicals; Chronic; Clinical; Cocaine; Common Rat Strains; Corticosterone; Cues; Data; Dependence, Substance; Dependence, Tobacco; Diagnostic; Dopamine; Drug Exposure; Drugs; Encephalon; Encephalons; Exposure to; Extinction; Extinction (Psychology); Food Deprivation; Food deprivation (experimental); Hour; Human; Human, General; Hydroxytyramine; IV drip; Ibotenic Acid; Individual; Intravenous; Intravenous Drip; Intravenous Infusion; Laboratories; Lesion; Literature; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Nervous System, Brain; Nucleus Accumbens; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; Play; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Process; Rat; Rattus; Relapse; Reticuloendothelial System, Serum, Plasma; Rewards; Role; Self Administration; Serum, Plasma; Sleep; Sleep Deprivation; Societies; Stress; Stria Terminalis Nucleus; Structure; Structure of terminal stria nuclei of preoptic region; Substance Addiction; Substance abuse problem; System; System, LOINC Axis 4; Testing; Tobacco Dependence; United States; abuse of substances; abused drugs; behavioral extinction; deprived of food; drip infusion; drug of abuse; drug seeking behavior; drug/agent; drugs abused; drugs of abuse; environmental stressor; experience; intravenous administration; meetings; neural mechanism; neuromechanism; novel; pathway; response; sleep control; sleep regulation; social role; substance abuse; tobacco addiction; vein infusion",The Effects of Sleep Deprivation on Cocaine Self-Administration and Relapse,,23315,NIDA,Neuropharmacology Research Subcommittee,,3,27307,
7745452,F31,DA,5,,01/01/2010,12/31/2010,PA-07-002,5F31DA024904-02,,NIDA:31304;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,PSYCHOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BERKMAN, ELLIOT TODD;",9168901;,5F31DA024904,01/01/2009,12/31/2010,"Abstinence; Address; Adopted; Affect; Affective; Attention; Behavior; Behavioral; Behavioral Research; BlackBerry Device; Blueberry Device; Brain; Cell Communication and Signaling; Cell Signaling; Cessation of smoking; Church; Cigarette; Cognition; Cognitive; Complex; Consumption; Data; Drug usage; Emotional; Encephalon; Encephalons; Enrollment; Environment; Functional Magnetic Resonance Imaging; Goals; Hand; Health Psychology; Hour; Incentives; Individual; Individual Differences; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knowledge; Laboratories; Lead; Link; Literature; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods and Techniques; Methods, Other; Modeling; Monitor; Motivation; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Neurosciences; Nuclear Magnetic Resonance Imaging; Outcome; PDA Computer; Palm Pilot; Palm-top; Palm-top computer; Palmtop; Palmtop computer; Participant; Patient Self-Report; Pb element; Personal Digital Assistant; Personal Digital Assistant Computer; Pocket PCs; Pocket Personal Computer; Process; Programs (PT); Programs [Publication Type]; Psychologist; Psychology, Health; Psychology, Social; Research; Sampling; Sampling Studies; Scientific Advances and Accomplishments; Self-Report; Signal Transduction; Signal Transduction Systems; Signaling; Smoker; Social Psychology; System; System, LOINC Axis 4; Techniques; Time; Work; Zeugmatography; base; biological signal transduction; cease smoking; cigarette smoking; cognitive neuroscience; drug use; enroll; experience; experiment; experimental research; experimental study; fMRI; heavy metal Pb; heavy metal lead; incentive; inducement; interventional strategy; mental representation; motor control; neural; neural mechanism; neuroimaging; neuromechanism; programs; psychologic; psychological; public health relevance; relating to nervous system; research study; response; scientific accomplishments; scientific advances; smoke cigarette; smoking cessation; social; success; theories",Smoking cessation from brain to the real world: an fMRI-experience sampling study,,24904,ZRG1,Special Emphasis Panel,,2,31304,
7777356,F31,DA,5,,01/01/2010,12/31/2010,,5F31DA024923-02,,NIDA:35573;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHICAGO,UNITED STATES,PHARMACOLOGY,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"GRAVES, STEVEN MICHAEL;",9173130;,5F31DA024923,01/01/2009,12/31/2011,"3,4-Dihydroxyphenethylamine; 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione; 3-(2-Aminoethyl)-1H-indol-5-ol; 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; 6-azamianserin; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AMPA Receptors; Abstinence; Adverse effects; Affinity; Americas; Amphetamines; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Assay; Attenuated; Behavior; Behavioral; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blotting, Western; Brain; Brain region; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Cells; Celltech brand of mirtazapine; Cocaine; Common Rat Strains; Crystal Meth; Data; Deoxyephedrine; Desoxyephedrine; Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-; Dopamine; Dose; Drug usage; Drugs; EC 2.7; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Enteramine; Environment; Event; Exposure to; Food; Funding; Globus Pallidus; Glutamates; Glycogen Synthase Kinases; Goals; Grant; Harvest; Hippophaine; Human; Human, General; Hydroxytyramine; Immunoblotting; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Ketanserin; Kinases; L-Glutamate; L-Serine; Locomotor Activity; Long-Term Potentiation; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Medication; Membrane Proteins; Membrane-Associated Proteins; Memory; Mentorship; Methamphetamine; Methamphetamine dependence; Methods; Methods and Techniques; Methods, Other; Methylamphetamine; Mianserin; Mirtazapine; Modeling; Molecular; Motor Activity; N-Methylamphetamine; NRSA; National Research Service Awards; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Neurophysiology / Electrophysiology; Neurosciences; Norset; Nucleus Accumbens; Organon brand of mirtazapine; Outcome; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Position; Positioning Attribute; Prefrontal Cortex; Procedures; Protein Phosphorylation; Protocol; Protocols documentation; Psychostimulant dependence; Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-; Rat; Rattus; Receptor Protein; Receptors, AMPA; Recovery; Relapse; Remergil; Remeron; Research Personnel; Researchers; Rewards; Rodent Model; Self Administration; Serine; Serotonin; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Surface; Surface Proteins; Synapses; Synaptic; Techniques; Testing; Therapeutic; Time; Training; Translational Research; Translational Research Enterprise; Translational Science; Transphosphorylases; Treatment Side Effects; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Western Blotting; Western Blottings; Western Immunoblotting; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-; Yohimbine; Zispin; addiction; attenuation; biological signal transduction; brain tissue; corynine; cross-link; crosslink; drug reward; drug use; drug/agent; effective therapy; indexing; inhibitor; inhibitor/antagonist; methamphetamine abuse; neural plasticity; neuroadaptation; neuronal; neuroplasticity; new therapeutics; next generation therapeutics; novel; novel therapeutics; pallidum; patch clamp; preference; protein blotting; protein expression; psychostimulant addiction; quebrachine; receptor; side effect; stimulant addiction; stimulant dependence; theories; therapy adverse effect; trafficking; translation research enterprise; treatment adverse effect; treatment program; treatment strategy","5HT receptors, neuronal plasticity, and methamphetamine-induced place perference.",,24923,ZRG1,Special Emphasis Panel,,2,35573,
7761777,F31,DA,5,,01/12/2010,01/11/2011,PA-07-002,5F31DA026318-02,,NIDA:41386;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KURAMOTO, SATOKO JANET;",9413575;,5F31DA026318,01/12/2009,01/11/2013,"18 year old; 21+ years old; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adult; Area; Attention; Awareness; Awarenesses; Baltimore; Behavior; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Causality; Communities; Data; Development; Drug abuse; Drug user; Drugs; Drugs, Illicit; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Equation; Etiology; Feeling suicidal; Goals; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Care Professional; Health Professional; Health behavior; Health profession; Healthcare professional; Healthcare worker; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Illicit Drugs; Individual; Injecting drug user; Injection Drug User; Intervention; Intervention Strategies; LAV-HTLV-III; Link; Literature; Lymphadenopathy-Associated Virus; Maryland; Mediating; Medication; Mental Health; Mental Hygiene; Methods; Modeling; NIDA; National Institute of Drug Abuse; Overdose; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Preventive Intervention; Programs (PT); Programs [Publication Type]; Prospective Studies; Psychological Health; Public Health; Recruitment Activity; Reporting; Research; Risk; Risk Behaviors; Risky Behavior; Smoker; Social Network; Social support; Statistical Methods; Structure; Suicidal thoughts; Suicide; Suicide attempt; Survey Instrument; Surveys; T-Lymphotropic Virus Type III Infections, Human; Transmission; Virus-HIV; Work; abuse of drugs; abuses drugs; adult human (21+); at risk behavior; community setting; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug/agent; eighteen year old; fatal attempt; fatal suicide; high risk; intent to die; interdisciplinary approach; interventional strategy; new approaches; non fatal attempt; novel approaches; novel strategies; novel strategy; preventional intervention strategy; programs; prospective; psychological distress; public health medicine (field); recruit; social; social integration; social support network; statistics/biometry; suicidal attempt; suicidal ideation; suicidal morbidity; suicidal risk; suicidal thinking; suicidality; suicide death; suicide ideation; suicide morbidity; suicide risk; thoughts about suicide; transmission process","Suicidal Ideation, Social Networks, HIV and Drug Oversdose:  A Methodological Foc",,26318,ZRG1,Special Emphasis Panel,,2,41386,
7756691,F31,DC,5,,02/01/2010,01/31/2011,PA-07-002,5F31DC009765-02,,NIDCD:32695;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,COLLEGE STATION,UNITED STATES,PSYCHOLOGY,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"FAVA, ESWEN ELIZABETH;",9308792;,5F31DC009765,02/01/2009,01/31/2012,"0-11 years old; 21+ years old; Adult; Age; Age Group Unspecified; American; Articulation; Auditory; Auditory Cortex; Auditory area; Behavioral; Bilateral; Boa; Brain; Cell Communication and Signaling; Cell Signaling; Child; Child Language; Child Youth; Children (0-21); Complex; Coupled; Data; Development; Dissociation; EEG; Electroencephalography; Encephalon; Encephalons; Environment; Equipment; Exposure to; Face; Functional Magnetic Resonance Imaging; Goals; Hearing; Human; Human, Adult; Human, Child; Human, General; Impairment; Infant; Influentials; Intracellular Communication and Signaling; Investigation; Joints; Language; Language Development; Left; Life; Lip; Lip Reading; Lip structure; Lipreading; MRI, Functional; Magnetic Resonance Imaging, Functional; Magnetoencephalography; Man (Taxonomy); Man, Modern; Maps; Measurable; Measures; Methods; Methods and Techniques; Methods, Other; Motion; Movement; NIR Spectroscopy; National Institute on Deafness and Other Communication Disorders; Nature; Near-Infrared Spectroscopy; Nervous; Nervous System, Brain; Neural Development; Participant; Pattern; Population; Process; Relative; Relative (related person); Reporting; Research; Role; Science of neurophysiology; Sensory; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sound; Sound - physical agent; Source; Spectrometry, Near-Infrared; Spectroscopy, Near-Infrared; Speech; Speech Perception; Speechreading; Stimulus; Techniques; Temporal Lobe; Testing; Time; Visual; Visual System; Visual system structure; Work; acquiring language skills; adult human (21+); age group; base; biological signal transduction; body movement; children; experience; experiment; experimental research; experimental study; fMRI; facial; hearing perception; language acquisition; language learning; language processing; neural; neural patterning; neurodevelopment; neurophysiology; prevent; preventing; relating to nervous system; research study; response; social role; sound; sound perception; speech processing; temporal cortex; temporal lobe/cortex; tool; visual information; visual process; visual processing; youngster",Neural contribution of visual speech to language development in preverbal infants,,9765,CDRC,Communication Disorders Review Committee,,2,32695,
7746471,F31,DK,5,,12/01/2009,11/30/2010,PA-07-106,5F31DK079421-03,,NIDDK:30312;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,WASHINGTON,UNITED STATES,,00,072641707,US,DC,20005,"CARNEGIE INSTITUTION OF WASHINGTON, D.C.","MIYARES, ROSA LINDA;",8828814;,5F31DK079421,09/15/2007,11/30/2010,"Absorption; Acid-Thiol Ligases; Acyl CoA; Acyl CoA Synthetases; Acyl Coenzyme A; Acyl Coenzyme A Synthetases; Address; Attenuated; Blood (Leukemia); Blood Cells; Blood Circulation; Blood Diseases; Blood erythrocyte; Blood normocyte; Bloodstream; Body Tissues; Brachydanio rerio; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Morphology; Circulation; Clinical; Co A Ligases; Coenzyme A Ligases; Coenzyme A Synthetases; Coupled; Danio rerio; Data; Defect; Development; Developmental Process; Embryo; Embryonic; Environment; Enzymes; Erythrocytes; Erythrocytic; Erythroid; Erythroid Cells; Erythropoiesis; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Acyl CoA; Fishes; Genes; Goals; Hematologic Diseases; Hematological Disease; Hematological Disorder; Human; Human, General; Image; Intermediary Metabolism; Intracellular Communication and Signaling; Knowledge; Larva; Leukemias, General; Lipids; Long-Chain Acyl CoA; METBL; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Membrane; Messenger RNA; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Microscopy; Molecular Transport; Monitor; Nature; Ortholog; Orthologous Gene; Pathway interactions; Pattern; Peripheral Blood Cell; Phenotype; Physiology; Play; Process of absorption; Proteins; RNA, Messenger; Reagent; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reticuloendothelial System, Erythrocytes; Role; Rosa; Rose; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staining method; Stainings; Stains; Techniques; Testing; Time; Tissues; Transcript; Transgenic Organisms; Transport Process; Very Long Chain Fatty Acid; Yolk Cell; Zebra Danio; Zebra Fish; Zebrafish; absorption; biological signal transduction; blood corpuscles; blood disorder; cell morphology; experiment; experimental research; experimental study; fat metabolism; fatty acid metabolism; fatty acid-transport protein; gene product; imaging; in vivo; leukemia; lipid metabolism; liquid chromatography mass spectroscopy; long chain fatty acid; mRNA; man; man's; membrane structure; migration; pathway; research study; social role; thiokinase; transgenic; zebrafish development",Fatty acid metabolism and signaling during zebrafish development,,79421,ZRG1,Special Emphasis Panel,,3,30312,
7715103,F31,DK,5,,12/01/2009,11/30/2010,PA-07-106,5F31DK083222-02,,NIDDK:25542;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"KOCALIS, HEIDI E.;",9448951;,5F31DK083222,12/01/2008,11/30/2011,"ACTH-beta-Lipotropin Precursor; AGRP protein; ART protein; Ablation; Agonist; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Autoregulation; Body Tissues; Brain; Brain Part; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Chemotherapy-Hormones/Steroids; Corticotropin-beta-Lipotropin Precursor; Data; Defect; Development; Diabetes Mellitus; Diet; Dietary Fats; Dietary Fatty Acid; Drug usage; Drugs; Dyslipidemias; Eating; Encephalon; Encephalons; Endocrine Gland Secretion; Endorphin-ACTH Precursor; Energy Expenditure; Energy Metabolism; Epidemic; Experimental Designs; Fats; Fatty Acids; Fatty Acids, Polyunsaturated; Fatty acid glycerol esters; Feedback; Food Intake; Genetic; Homeostasis; Hormones; Humulin R; Hypothalamic structure; Hypothalamus; Immunoglobulin Enhancer-Binding Protein; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Laboratories; Lead; Leptin; Leptin resistance; Ligands; Mammals, Mice; Mammals, Rodents; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mentors; Metabolic; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuron Degeneration; Neurons; Neuropeptide Tyrosine; Novolin R; Nuclear Factor kappa B; Nuclear Receptors; Nuclear Transcription Factor NF-kB; Null Mouse; Nutritional; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; POMC; PPAR; PPAR gamma; PPARG; PPARG1; PPARG2; PPARgamma; Partner in relationship; Pathogenesis; Pb element; Peripheral; Peroxisome Proliferative Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor gamma; Peroxisome Proliferator-Activated Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Play; Polyunsaturated Fatty Acids; Predisposition; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Pro-Opiomelanocortin; Proopiocortin; Proopiomelanocortin; Publishing; Receptor Protein; Research Personnel; Researchers; Resistance; Rodent; Rodentia; Rodentias; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Susceptibility; Therapeutic Hormone; Thiazolidinedione Receptor; Tissues; Transcription Factor NF-kB; Weight Gain; Weight Increase; Work; adiposity; agouti-related protein; biological signal transduction; body weight gain; body weight increase; cell type; corpulence; corpulency; corpulentia; diabetes; dietary lipid; drug use; drug/agent; experiment; experimental research; experimental study; feeding; glucose metabolism; heavy metal Pb; heavy metal lead; hypothalamic; improved; insulin sensitivity; insulin sensitizer; insulin sensitizing drugs; kappa B Enhancer Binding Protein; mate; model organism; nestin; nestin protein; neural control; neural degeneration; neural regulation; neurodegeneration; neuronal; neuronal degeneration; neuropeptide Y; neuroregulation; nuclear factor kappa beta; ob/ob mouse; obese; obese people; obese person; obese population; polyunsaturated fatty acid; receptor; research study; resistant; social role; wt gain",CNS PPAR gamma and energy homeostasis,,83222,ZRG1,Special Emphasis Panel,,2,25542,
7752538,F31,EY,5,,01/01/2010,12/31/2010,PA-07-106,5F31EY019441-02,,NEI:45663;,2010,NATIONAL EYE INSTITUTE,,NEW HAVEN,UNITED STATES,ENGINEERING (ALL TYPES),03,043207562,US,CT,065208047,YALE UNIVERSITY,"ROBINSON, REBECCA ;",9452690;,5F31EY019441,01/01/2009,12/31/2010,"21+ years old; ATP[{..}]protein-tyrosine O-phosphotransferase; Acute; Address; Administration, Oral; Adult; Adverse effects; Affect; Animals; Anterior Quadrigeminal Body; Anthelone U; Antibodies; Area; Assay; Astrocytes; Astrocytus; Astroglia; Axon; Axotomy; B-50 Protein; Bioassay; Biologic Assays; Biological Assay; Biological Neural Networks; Cell Differentiation; Cell Differentiation process; Cell Transplantation; Cell Transplants; Cells; Cellular injury; Central Nervous System; Chondroitin Sulfate Proteoglycan; Cicatrix; Combined Modality Therapy; Common Rat Strains; Compliance behavior; Corpora quadrigemina, superior colliculus; Cranial Nerve II; Cranial Nerve II Injuries; Crush Injury; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Diarrhea; Dose; Drug Administration, Oral; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EGF; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR-TK Inhibitor; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; Effectiveness; Emulsions; Encapsulated; Engineering; Engineerings; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epidermal Growth Factor-Urogastrone; Event; Exanthem; Exanthema; Eye; Eye Socket; Eyeball; Fats; Fatty acid glycerol esters; Fiber; Fluorescence Microscopy; Functional impairment; Future; GAP-43; GAP-43 Protein; GAP43 Protein; GFP; Ganglion Cells (Retina); Glaucoma; Glycolates; Goals; Gray; Gray unit of radiation dose; Green Fluorescent Proteins; Growth Associated Protein 43; HEK3; HER1; Human Urinary Gastric Inhibitor; Human, Adult; Hydrogels; Immunoblotting; Implant; In Vitro; Injection of therapeutic agent; Injections; Injury; Lytotoxicity; Mammals, Rats; Medulla Spinalis; Methods and Techniques; Methods, Other; Microbeads; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Microspheres; Modeling; Modification; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Myelopathy, Traumatic; Natural regeneration; Nerve; Nerve Cells; Nerve Crush; Nerve Growth Cone Membrane Protein GAP-43; Nerve Regeneration; Nerve Unit; Nervous; Nervous System, CNS; Neural Cell; Neural Stem Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuromodulin; Neurons; Ocular orbit; Optic Nerve; Optic Nerve Injuries; Optic Nerve Trauma; Optic Neuropathy, Traumatic; Optic Tectum; Oral Administration; Orbit; Orbital Cavity; PTK; Patient Compliance; Patient Cooperation; Phosphate Buffer; Phosphoprotein B-50; Phosphoprotein F1; Phosphoprotein pp46; Polymers; Production; Progenitor Cell Transplantation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Rash; Rat; Rattus; Receptor Inhibition; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Recovery of Function; Regeneration; Retina; Retinal; Retinal Degeneration; Retinal Ganglion Cells; Saline; Saline Solution; Scars; Second Cranial Nerve; Second Cranial Nerve Injuries; Second Cranial Nerve Trauma; Series; Side; Signal Pathway; Site; Skin Rash; Solutions; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stem Cell Transplantation; Stem cell transplant; Superior Colliculus; System; System, LOINC Axis 4; Target Populations; Techniques; Tectums, Optic; Testing; Transforming Growth Factor alpha Receptor; Transplantation; Transplants, Cell; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Treatment Compliance; Treatment Side Effects; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Urogastrone; adult human (21+); axon regeneration; axonal regeneration; base; beta-Urogastrone; biocompatibility; biomaterial compatibility; c-erbB-1; c-erbB-1 Protein; cell damage; cell injury; clinical applicability; clinical application; combination therapy; combinatorial; combined modality treatment; combined treatment; compliance cooperation; controlled release; cytotoxicity; degenerative condition; degenerative disease; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; functional disability; functional recovery; glaucomatous; hydroxyaryl protein kinase; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; injured; intraoral drug delivery; macrophage; minimally invasive; monolayer; multimodality therapy; nerve stem cell; nervous system regeneration; neural growth associated protein; neural network; neural progenitor cells; neural regeneration; neurodegenerative illness; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal progenitor; neuronal progenitor cells; novel; optic nerve regeneration; patient adherence; proto-oncogene protein c-erbB-1; receptor expression; regenerate; repair; repaired; retina degeneration; retinal degenerative; retinal ganglion; side effect; substantia alba; superior colliculus Corpora quadrigemina; therapy adverse effect; therapy compliance; therapy cooperation; transplant; traumatic brain damage; treatment adverse effect; treatment effect; tyrosyl protein kinase; ultraviolet; visual tectum; white matter",Polymer Constructs for Axon Regeneration in the Central Nervous System,,19441,ZRG1,Special Emphasis Panel,,2,45663,
7762778,F31,GM,5,,02/01/2010,11/30/2010,PA-00-069,5F31GM075423-05,,NIGMS:40368;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,NEUROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"AGYEMANG, AMMA F;",7746178;,5F31GM075423,02/01/2006,11/30/2010,Fellowship Program; Minority; pre-doc; pre-doctoral; predoc; predoctoral,Minority Predoctoral Fellowship Program,,75423,ZRG1,Special Emphasis Panel,,5,40368,
7761215,F31,GM,5,,02/01/2010,01/31/2011,PAR-03-114,5F31GM076982-05,,NIGMS:29733;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"GUTIERREZ, MARIA A;",6941972;,5F31GM076982,02/01/2006,01/31/2011,"Adverse effects; Agammaglobulinaemia tyrosine kinase; Age; Antibodies; Antibodies, Antinuclear; Antigen-Antibody Complex; Antinuclear Antibodies; Antinuclear Factors; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B cell differentiation; B cell differentiation factor; B cell progenitor kinase; B cell stimulating factor 2; B lymphocyte differentiation; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; B-Cells; B-Lymphocytes; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood Plasma Cell; Blood granulocytic cell; Blood monocyte; Bone Marrow; Bruton's tyrosine kinase; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Characteristics; Complement Activation; Defect; Deposit; Deposition; Development; Differentiation Factor, B-Cell; Disease; Disorder; EC 2.7; Exhibits; Fellowship; Frequencies (time pattern); Frequency; Genes; Granular Leukocytes; Granulocytic cell; HPGF; Hepatocyte-Stimulating Factor; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Immune; Immune Complex; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Individual; Infiltration; Inflammation; Injuries, Multiple; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Knockout Mice; Lead; Link; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; MGI-2; Macrophages, Peritoneal; Mammals, Mice; Marrow monocyte; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Multiple Trauma; Murine; Mus; Myelogenous; Myeloid; Myeloid Cell Activation; Myeloid Cells; Myeloid Differentiation-Inducing Protein; Myeloid Disease; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; Names; Natural immunosuppression; Null Mouse; Onset of illness; Organ; Pathogenesis; Patients; Pb element; Peripheral; Peritoneal Macrophages; Phenotype; Phosphotransferases; Plasma Cells; Plasmacytes; Plasmacytoma Growth Factor; Play; Population; Production; Reticuloendothelial System, Bone Marrow; Role; SLE; SLE - Lupus Erythematosus, Systemic; Signal Transduction; Signal Transduction Systems; Signaling; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Transphosphorylases; Treatment Side Effects; Wounds, Multiple; anti-Sm; antiDNA autoantibody; autoimmune antibody; autoimmune disorder; biological signal transduction; bpk protein; btk protein; cell engineering; cellular engineering; complement pathway regulation; cross-link; crosslink; cytokine; disease onset; disease/disorder; disorder onset; disseminated lupus erythematosus; granulocyte; heavy metal Pb; heavy metal lead; immunosuppression; insight; interest; interferon beta 2; macrophage; monocyte; myeloproliferative neoplasm; novel; plasmocyte; self reactive antibody; self recognition (immune); side effect; social role; systemic lupus erythematosis; therapy adverse effect; treatment adverse effect",Role of Hyperresponsive Myeloid Cells in Murine Lupus,,76982,MPRC,Minority Programs Review Committee,,5,29733,
7795023,F31,GM,5,,02/01/2010,01/31/2011,PA-07-106,5F31GM084682-02,,NIGMS:40358;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CLEVELAND,UNITED STATES,BIOMEDICAL ENGINEERING,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"SPIRES, JESSICA ROSE;",9159019;,5F31GM084682,02/01/2009,01/31/2012,"1,5-dihydro-FAD; ATP biosynthesis (oxidative); Affect; Age; Aging; Animal Experiments; Animals; Autoregulation; Body Tissues; Buccal Cavity; Canine Species; Canis familiaris; Cavitas Oris; Cell Communication and Signaling; Cell Respiration; Cell Signaling; Cellular Respiration; Chronic; Citric Acid Cycle; Complex; Computer Simulation; Computerized Models; Consumption; Cystic Fibrosis; Data; Dehydrogenases; Diabetes Mellitus; Diagnostic; Disease; Disorder; Dogs; Electronics; Energy Expenditure; Energy Metabolism; Energy Transfer; Exercise; Exercise, Physical; Experiments, Animal; FADH2; Generations; Glycolysis Pathway; Head and Neck, Buccal Cavity; Heart failure; Homeostasis; Human; Human, General; Hypoxia; Hypoxic; In Vitro; Intermediary Metabolism; Intracellular Communication and Signaling; Krebs Cycle; Lung; METBL; Mammals, Dogs; Man (Taxonomy); Man, Modern; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Metabolic; Metabolic Processes; Metabolism; Mitochondria; Mitochondria, Muscle; Modeling; Models, Computer; Moderate Activity; Moderate Exercise; Mouth; Mucoviscidosis; Muscle; Muscle Mitochondria; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NADH; O element; O2 element; Oral cavity; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxidoreductase; Oxygen; Oxygen Consumption; Oxygen Deficiency; Pathway interactions; Patients; Physiological Homeostasis; Production; Publishing; Reaction; Reductases; Regulation; Relative; Relative (related person); Research Training; Respiration; Respiratory Chain; Respiratory System, Lung; Rest; Role; Sarcosomes; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Skeletal Muscle Tissue; Skeletal muscle structure; TCA cycle; Testing; Tissues; Training; Tricarboxylic Acid Cycle; Work; adenylate; aerobic metabolism; aerobic respiration; biological signal transduction; canine; cardiac failure; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; diabetes; disease/disorder; domestic dog; enzyme activity; experiment; experimental research; experimental study; fatty acid oxidation; in silico; in vivo; mathematical model; mathematical modeling; mitochondrial; models and simulation; oxidation; oxidative metabolism; oxygen transport; pathway; pulmonary; research study; respiratory mechanism; response; senescent; social role; tool; training project; uptake; virtual simulation",Mechamism of Activation of Oxidative Metabolism in vivo During Exercise,,84682,ZRG1,Special Emphasis Panel,,2,40358,
7758843,F31,GM,5,,01/01/2010,12/31/2010,PA-07-106,5F31GM084692-02,,NIGMS:30312;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AUSTIN,UNITED STATES,CHEMISTRY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"MITCHELL, DAVID ;",9204001;,5F31GM084692,01/01/2009,12/31/2011,"3-D structure; 3-dimensional structure; 3D structure; Binding; Binding (Molecular Function); Biological Function; Biological Process; Biology; Boxing; Cancers; Carbamide; Catalytic RNA; Cells; Chaperone; Complex; Cytochrome c Reductase; Diaphorase (NADH Dehydrogenase); Disease; Disorder; Effectiveness; Elaqua XX; Ensure; Family; Gene Expression; Gene Products, RNA; Goals; In Vitro; Incubated; Intervening Sequences; Introns; Investigation; Life; Malignant Neoplasms; Malignant Tumor; Measures; Mediating; Medical; Methods and Techniques; Methods, Other; Mitochondria; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; NADH (Acceptor) Oxidoreductase; NADH Cytochrome c Oxidoreductase; NADH Cytochrome c Reductase; NADH Dehydrogenase; Nature; Neurospora; Neurospora crassa; Organism; Physiologic; Physiological; Proteins; RNA; RNA Binding; RNA Folding; RNA Splicing; RNA, Non-Polyadenylated; RNA, Small Interfering; RNA-Binding Proteins; RNA-Protein Interaction; Reaction; Research; Ribonucleic Acid; Ribozymes; Role; Small Interfering RNA; Solutions; Splicing; Structure; Techniques; Temperature; Testing; Tetrahymena; Uncertainty; Urea; Urea Carbamide; Ureaphil; Work; base; cofactor; conformation; conformational state; design; designing; disease/disorder; doubt; gene product; in vivo; insight; living system; malignancy; mitochondrial; neoplasm/cancer; prevent; preventing; siRNA; social role; three dimensional structure",Probing Refolding of a Misfolded Group I RNA by its Cognate DEAD-box Chaperone,,84692,ZRG1,Special Emphasis Panel,,2,30312,
7770790,F31,GM,5,,02/01/2010,01/31/2011,PA-07-002,5F31GM087096-02,,NIGMS:29476;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,CHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"DEROCCO, VANESSA CAROLYN;",9300076;,5F31GM087096,02/01/2009,01/31/2012,"ATP Hydrolysis; Apoptosis; Apoptosis Pathway; Base-Base Mismatch; Binding; Binding (Molecular Function); Cell Death; Cell Death, Programmed; Cells; Chromatin Loop; Chromatin Loop Domains; Color; Colorectal Cancer; Coloring Agents; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; DNA Damage; DNA Damage Repair; DNA Injury; DNA Loop; DNA Repair; DNA Repair Pathway; Data; Deoxyribonucleic Acid; Drugs; Dyes; Energy Transfer; Fluorescence Microscopy; Frequencies (time pattern); Frequency; GeneHomolog; Genetic Alteration; Genetic Change; Genetic defect; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; Hydrolysis; Image; Kinetic; Kinetics; Lead; MMR; Man (Taxonomy); Man, Modern; Medication; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mismatch Repair; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutation; Nature; Nucleotides; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Post-Replication Mismatch Repair; Process; Protein Motifs, DNA-Binding; Proteins; Role; Site; Structure; System; System, LOINC Axis 4; Unscheduled DNA Synthesis; Yeasts; base; conformation; conformational state; drug/agent; experiment; experimental research; experimental study; fluorophore; gene product; genome mutation; heavy metal Pb; heavy metal lead; imaging; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; mutant; necrocytosis; pathway; repair; repaired; research study; response; single molecule; single-molecule FRET; single-molecule fluorescence resonance energy transfer; smFRET; social role",Single Molecule Studies of the Role of yMsh2-Msh6 in DNA Mismatch Repair,,87096,ZRG1,Special Emphasis Panel,,2,29476,
7877752,F31,GM,5,,01/01/2010,12/31/2010,PA-07-106,5F31GM087108-02,,NIGMS:30379;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,CHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"NEAL, SONYA E.;",9448191;,5F31GM087108,01/01/2009,12/31/2013,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acids; Assay; Bioassay; Biochemical; Biochemical Genetics; Biochemistry; Biogenesis; Biologic Assays; Biological Assay; Biological Models; CRP; Cardiac; Cells; Chemistry; Chemistry, Biological; Cysteine; Cytochrome c Peroxidase; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Disorder of muscle, unspecified; Disulfides; Doctor of Philosophy; Electrons; Environment; FAD-dependent sulfhydryl oxidase; Fe element; Ferricytochrome c; Ferrocytochrome c; Ferrocytochrome c[{..}]hydrogen-peroxide oxidoreductase; Fluorescence; Future; Genetic; Genetic, Biochemical; Goals; Half-Cystine; Idiopathic Parkinson Disease; Injury; Intermediary Metabolism; Iron; Ischemia; L-Cysteine; L-Tryptophan; Lead; Levotryptophan; Lewy Body Parkinson Disease; Link; Lipids; METBL; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Mediating; Mercaptans; Mercapto Compounds; Metabolic Pathway; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Mitochondria; Mitochondrial Myopathies; Model System; Modeling; Models, Biologic; Molecular; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Negative Beta Particle; Negatrons; Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neuropathy; O element; O2 element; Organelles; Origin of Life; Oxidants; Oxidation-Reduction; Oxidizing Agents; Oxygen; PARK6 protein; PINK1 gene product; PINK1 protein; PTEN induced putative kinase 1; PTEN-induced putative kinase; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pb element; Perfusion; Periplasmic Space; Ph.D.; PhD; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Production; Property; Property, LOINC Axis 2; Protein Import; Proteins; Proteome; Public Health; Reaction; Redox; Role; S cerevisiae; S element; SOx enzyme; Saccharomyces cerevisiae; Science of Chemistry; Sulfhydryl Compounds; Sulfur; Temperature; Testing; Thiols; Titrations; Tryptophan; Yeast, Baker's; Yeast, Brewer's; Yeasts; aminoacid; cysteine rich protein; cytochrome c; dementia of the Alzheimer type; disease/disorder; disulfide bond; electron acceptor; gene product; graduate student; heavy metal Pb; heavy metal lead; human disease; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; kohl; mitochondrial; mitochondrial dysfunction; muscular disorder; mutant; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; neuropathic; novel; oxidation; oxidation reduction reaction; pathway; periplasm; periplasmic; primary degenerative dementia; protein kinase BRPK; public health medicine (field); reconstitute; reconstitution; senile dementia of the Alzheimer type; serine/threonine-protein kinase PINK1; small molecule; social role; sulfhydryl group; sulfhydryl oxidase; sulphydryloxidase",Characterization of redox-mediated protein in mitochondria,,87108,ZRG1,Special Emphasis Panel,,2,30379,
7758367,F31,HL,5,,02/01/2010,01/31/2011,PA-00-069,5F31HL085928-04,,NHLBI:32825;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CLEVELAND,UNITED STATES,CHEMISTRY,11,010841617,US,OH,44115,CLEVELAND STATE UNIVERSITY,"HIRBAWI, JAMILA ;",8546418;,5F31HL085928,02/01/2007,01/31/2011,"AC Globulin; Acidic Amino Acids; Amino Acids; Amino Acids, Acidic; Applications Grants; Assay; Autoprothrombin C; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; Blood Clotting; Blood Coagulation Factor; Blood Coagulation Factor II; Blood Coagulation Factor III; Blood Coagulation Factor V; Blood Coagulation Factor V, Activated; Blood Coagulation Factor X, Activated; Blood coagulation; Blood-coagulation factor Va; Blotting, Western; CD142 Antigens; Cells; Clotting; Coagulation; Coagulation Factor II; Coagulation Factor III; Coagulation Factor V; Coagulation Factor Va; Coagulation Factor Xa; Coagulation Factors; Coagulation Process; Coagulin; Data; Deep Vein Thrombosis; Deep-Venous Thrombosis; Development; Differentiation Reversal Factor; Enzymes; Esteroproteases; Factor II; Factor III; Factor Pi; Factor V; Factor V, Activated; Factor Va; Factor X, Activated; Factor Xa; Generations; Glomerular Procoagulant Activity; Goals; Grant Proposals; Grants, Applications; Hemostasis; Hemostatic function; Human; Human Figure; Human body; Human, General; Individual; Ions; Kinetic; Kinetics; Life; Light; Man (Taxonomy); Man, Modern; Measures; Membrane; Methods; Molecular Interaction; Pathway interactions; Peptidases; Peptide Hydrolases; Photoradiation; Plasmids; Proaccelerin; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Prothrombin; Prothrombinase; Reaction; Recombinant Proteins; Regulation; Research; Role; Staging; Structure; Surface; Thrombase; Thrombin; Thrombin, meizo-; Thrombokinase; Thromboplastin; Thrombosis; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Urothromboplastin; Western Blotting; Western Blottings; Western Immunoblotting; aminoacid; base; clotting factor; cofactor; divalent metal; fibrinogenase; gene product; labile component; labile factor; meizothrombin; membrane structure; mutant; pathway; protein blotting; prothrombase; prothrombinase complex; social role",Factor Va regulation of prothrombinase activity,,85928,ZRG1,Special Emphasis Panel,,4,32825,
7755890,F31,HL,5,,01/16/2010,01/15/2011,PA-07-106,5F31HL091723-03,,NHLBI:29773;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,PATHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"PERRY, CYNTHIA ;",8930369;,5F31HL091723,01/16/2008,01/15/2012,"Abscission; Actins; Apoptosis; Apoptosis Pathway; Autophagocytosis; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Survival; Cell Viability; CellLine; Cells; Coenzyme Q-Cytochrome-c Reductase; Coenzyme QH2-Cytochrome-c Reductase; Complex; Complex III; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cytochrome b-c2 Oxidoreductase; Cytofluorometry, Flow; Cytoplasmic Organelle; Desmin; Development; Dihydroubiquinone-Cytochrome-c Reductase; DsRed; Electron Transport Complex III; Elements; Endoplasmic Reticulum; Ergastoplasm; Excision; Extirpation; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence Microscopy; HTRPY; Heart; Heart failure; Heart myocyte; Housekeeping; Housework; Hypertrophy; Individual; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Lead; Lysosomes; Membrane; Microfluorometry, Flow; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitochondria; Molecular; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocytes, Cardiac; Organelles; Organism-Level Process; Organismal Process; Oxidative Stress; Pathway interactions; Pb element; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Play; Process; Proteins; QH(2)-Cytochrome-c Reductase; QH(2)-Ferricytochrome-c Oxidoreductase; Recycling; Regulation; Removal; Reperfusion Therapy; Reporter; Role; Skeletin; Starvation; Stimulus; Stress; Surgical Removal; Testing; Therapeutic Agents; Ubihydroquinone-Cytochrome-c Reductase; Ubiquinol-Cytochrome-c Reductase; Ubiquinol-ferricytochrome-c oxidoreductase; Ubiquinone-Cytochrome b-c2 Oxidoreductase; autophagy; cardiac failure; cardiac infarct; cardiomyocyte; coronary attack; coronary infarct; coronary infarction; cultured cell line; flow cytophotometry; gene product; heart attack; heart infarct; heart infarction; heart ischemia; heavy metal Pb; heavy metal lead; injury response; membrane structure; mitochondrial; monomer; myocardial ischemia/hypoxia; myocardium ischemia; necrocytosis; new therapeutics; next generation therapeutics; novel therapeutics; pathway; prevent; preventing; protein aggregation; reperfusion; resection; response; response to injury; social role; tool; uptake",Subcellular Regulation of Autophagic Flux in Cardiomyocytes and the Heart,,91723,ZRG1,Special Emphasis Panel,,3,29773,
7783815,F31,HL,5,,01/01/2010,12/31/2010,PA-07-106,5F31HL092785-02,,NHLBI:45180;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MADISON,UNITED STATES,BIOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HOFFMAN, MICHAEL SHAMAINE;",9203880;,5F31HL092785,01/01/2009,12/31/2010,"5-HT Receptors; 5-Hydroxytryptamine Receptors; Active Oxygen; Acute; Adenosine; Adenosine A(2A) Receptor; Adenosine A2A Receptor; Affinity; BDNF; BDNF Receptor; BDNF/NT-3 Growth Factors Receptor; Brain-Derived Neurotrophic Factor; Cell Nucleus; Cells; Cellular Membrane; Cervical; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Doctor of Philosophy; Elements; GP145-TRKB; Goals; Hypoxia; Hypoxic; MGC34632; Modeling; Motor; Myelopathy, Traumatic; NADPH Oxidase; NTRK2; NTRK2 Receptor; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurotrophic Factor, Brain-Derived, Receptor; Neurotrophic Tyrosine Kinase Receptor Type 2; Nucleus; Obstructive Sleep Apnea; Oxygen Deficiency; Oxygen Radicals; P1 Purinoceptors; PTK Receptors; Patients; Peptide Biosynthesis, Ribosomal; Ph.D.; PhD; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Play; Pro-Oxidants; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Serine/Threonine Phosphatase; Protein Synthesis, Ribosomal; Protein phosphatase; Purinergic P1 Receptors; RTK; Reactive Oxygen Species; Receptor Activation; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Adenosine; Receptors, Purinergic P1; Respiratory Insufficiency; Role; Sleep Apnea, Obstructive; Spinal; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Superoxide Anion; Superoxide Radical; Superoxides; Syndrome, Sleep Apnea, Obstructive; TRKB; TRKB Tyrosine Kinase; Testing; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; disease control; disorder control; interdisciplinary approach; motor control; neurodegenerative illness; novel therapeutic intervention; protein synthesis; receptor; respiratory; serine-threonine phosphatase; serotonin receptor; social role; trkB(gp145) Protein",Enhancement of Phrenic Long-Term Facilitation Following Intermittent Hypoxia,,92785,ZRG1,Special Emphasis Panel,,2,45180,
7715105,F31,HL,5,,01/10/2010,12/31/2010,PA-07-106,5F31HL094162-02,,NHLBI:30489;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BERKELEY,UNITED STATES,BIOMEDICAL ENGINEERING,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"HENRY, JEFFREY JUSTIN DAVID;",9314217;,5F31HL094162,01/01/2009,12/31/2012,"Accounting; Area; Biocompatible Materials; Biology; Biomaterials; Biomedical Engineering; Blood Vessels; Bypass; Caliber; Cardiovascular Diseases; Cause of Death; Cell Locomotion; Cell Migration; Cell Movement; Cell-Extracellular Matrix; Cells; Cellular Migration; Cessation of life; Chemicals; Death; Development; Diameter; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; ECM; Endothelial Cells; Engineering; Engineerings; Extracellular Matrix; Goals; Infiltration; Knowledge; Modification; Morbidity; Morbidity - disease rate; Motility; Motility, Cellular; Nanoscale Science; Nanotechnology; Operation; Operative Procedures; Operative Surgical Procedures; Procedures; Surface; Surgical; Surgical Interventions; Surgical Procedure; Thrombosis; United States; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular Graft; Vegf; Veins; Woman; bioengineering; bioengineering/biomedical engineering; blood vessel disorder; cardiovascular disorder; cell motility; common treatment; men; men's; nano fiber; nano scale Science; nano tech; nano technology; nanofiber; nanofibrous; nanotech; surgery; tool; vascular",Development of nanofibrous vascular grafts with efficent angiogenic potential,,94162,ZRG1,Special Emphasis Panel,,2,30489,
7769880,F31,HL,5,,02/04/2010,02/03/2011,PA-07-106,5F31HL095273-02,,NHLBI:27609;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,KANSAS CITY,UNITED STATES,MISCELLANEOUS,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"VANHOOSE, LISA DELORES;",8924097;,5F31HL095273,02/04/2009,02/03/2011,"0-11 years old; 21+ years old; Acylcholesterol Lipase; Address; Adipocytes; Adipose Cell; Adipose tissue; Adult; Aerobic Activity; Aerobic Exercise; African; American; Animal Model; Animal Models and Related Studies; Apoplexy; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood Serum; Body System, Dermatologic; Cachectin; Cachectin-Tumor Necrosis Factor; Calorimetry, Indirect; Calorimetry, Respiration; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiomyopathies; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cause of Death; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Characteristics; Child; Child Youth; Children (0-21); Cholesterol Ester Hydrolase; Cholesterol Esterase; Cholesteryl Oleate Hydrolase; Cholesterylester Hydrolase; Chronic; Common Rat Strains; Control Groups; Coupled; DAG lipase; Death; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diacylglycerol Lipase; Differentiation Factor, B-Cell; Diglyceride Lipase; Disease; Disorder; Dysfunction; Dyslipidemias; Epidemic; Equilibrium; Evaluation; Exercise; Exercise, Physical; Eye; Eyeball; Fat Cells; Fatty Tissue; Functional disorder; Gene Expression; Genital System, Male, Prostate; HPGF; HTRPY; Health; Heart Diseases; Heparin-Clearing Factor; Hepatocyte-Stimulating Factor; Hispanic Americans; Hormone-Sensitive Lipase; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, Child; Human, General; Hybridoma Growth Factor; Hyperglycemia; Hyperlipemia; Hyperlipidemia; Hyperplasia; Hyperplastic; Hypertrophy; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Incidence; Indirect Calorimetry; Infiltration; Inflammation; Inflammatory; Institution; Insulin Resistance; Intake; Integral Membrane Protein; Integument; Integumentary system; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intermediary Metabolism; Intervention; Intervention Strategies; Intrinsic Membrane Protein; LPL; Left Ventricular Function; Life Style; Lifestyle; Lipemia-Clearing Factor; Lipocytes; Lipoidal Steroid Esterase; Lipolysis; METBL; MGI-2; MODY; Mammals, Rats; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Metabolic; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Microscopy; Mission; Modeling; Molecular; Monitor; Muscle, Skeletal; Muscle, Voluntary; Mycocardium Disease; Myeloid Differentiation-Inducing Protein; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; NIDDM; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ System, Cardiovascular; Organ System, Dermatologic; Outcome Study; Over weight; Overweight; Pathology; Performance; Persons; Physiopathology; Plasmacytoma Growth Factor; Population; Post-Heparin Lipase; Postheparin Lipase; Postheparin Lipoprotein Lipase; Prevention; Process; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; Proteins; Rat; Rat model of diabetes; Rattus; Recommendation; Research; Risk Factors; Role; Sampling; Sedentary Exercise; Sensory; Serum; Skeletal Muscle Tissue; Skeletal muscle structure; Spanish Americans; Steroid Hormone Esterase; Sterol Ester Acylhydrolase; Steryl-ester acylhydrolase; Stroke; Study, Outcome; T2D; T2DM; TNF-alpha; Techniques; Testing; Time; Training; Transmembrane Protein; Triacylglycero-protein acylhydrolase; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Type 2 diabetes; Type II diabetes; United States; United States National Institutes of Health; Vascular Accident, Brain; Vascular, Heart; Ventricular Function, Left; Very Light Activity; Very Light Exercise; adipogenesis; adipose; adiposity; adult human (21+); adult onset diabetes; balance; balance function; brain attack; cardiac disease risk; cardiac disorder risk; cardiovascular disorder; cerebral vascular accident; children; cholesteryl ester synthase; circulatory system; clearing factor lipase; corpulence; corpulency; corpulentia; cytokine; diabetes; diabetes management; diabetic; diabetic rat; diabetic rat model; disease/disorder; early onset; experiment; experimental research; experimental study; gastrointestinal; gene product; heart disease risk; heart disorder; heart disorder risk; hemodynamics; hyperglycemic; inflammatory marker; insulin resistant; interferon beta 2; interventional strategy; ketosis resistant diabetes; lipid biosynthesis; lipogenesis; lipoprotein lipase; macrophage; maturity onset diabetes; meetings; model organism; myocardium disorder; obese; obese people; obese person; obese population; pathophysiology; programs; research study; sedentary; social role; sterol esterase; stroke; triacylglycerol protein acylhydrolase; triterpenol esterase; white adipose tissue; yellow adipose tissue; youngster",EXERCISE DELAYS DIABETIC HEART DISEASE BY REDUCING ADIPOSE-RELATED INFLAMMATION,,95273,ZRG1,Special Emphasis Panel,,2,27609,
7787488,F31,MH,5,,03/09/2010,03/08/2011,PA-07-002,5F31MH084380-02,,NIMH:31120;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOS ANGELES,UNITED STATES,PSYCHOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"KIRCANSKI, KATHARINA ;",9226734;,5F31MH084380,03/09/2009,03/08/2011,"Affect; Affective; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Experimental Use; Animal Experimentation; Animal Research; Anxiety; Anxiety Disorders; Attenuated; Basic Behavioral Science; Basic Research; Basic Science; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Chronotropism, Cardiac; Chronotropisms, Cardiac; Cognition; Cognitive; Conditioning Therapy; Distraction; Effectiveness; Electrodermal Response; Emotional; Emotions; Exposure to; Extinction; Extinction (Psychology); Fear; Finding of distraction; Fright; GSR; Galvanic Skin Response; Goals; Health; Heart Rate; Human; Human, General; Label; Language; Learning; Life Style Modification; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measures; Methods; Modality; Nervous; Neurosciences; Participant; Pathway interactions; Patient Self-Report; Patients; Phobias; Phobic Disorders; Phobic Neuroses; Phobic anxiety disorder; Physiologic; Physiological; Pilot Projects; Prefrontal Cortex; Process; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Reflex, Psychogalvanic; Relative; Relative (related person); Reporting; Research; Sampling; Self-Report; Skin Electric Conductance; Spiders; Stimulus; Testing; Translating; Translatings; Translations; amygdaloid nuclear complex; base; behavior intervention; behavioral extinction; behavioral intervention; clinical relevance; clinically relevant; distraction; improved; indexing; innovate; innovation; innovative; language translation; neural; new approaches; novel approaches; novel strategies; novel strategy; pathway; pilot study; psycho-physiological; public health relevance; relating to nervous system; response; self reported behavior; theories; tool; translational approach",Translating Language-Emotion Interactions in Exposure Therapy,,84380,ZRG1,Special Emphasis Panel,,2,31120,
7672511,F31,MH,5,,02/12/2010,02/11/2011,PA-07-002,5F31MH084714-02,,NIMH:41380;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PEDIATRICS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"REYNOLDS, LINDSEY JEANNE;",9308137;,5F31MH084714,08/01/2008,02/11/2012,"0-11 years old; AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Advocate; Affect; Africa, Southern; African; Aid, Foreign; Analysis, Data; Area; Availability of Health Services; Caring; Categories; Cessation of life; Child; Child Youth; Children (0-21); Classification; Communities; Country; Data Analyses; Death; Decision Making; Development; ELIG; Eligibility; Eligibility Determination; Emergencies; Emergency Situation; Enrollment; Epidemic; Ethnography; Family; Foreign Aid; Funding; Goals; Government; Guidelines; HIV; HIV/AIDS; HIV/AIDS problem; HTLV-III; Health Services Accessibility; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Child; Immunologic Deficiency Syndrome, Acquired; Individual; Intervention; Intervention Strategies; Investigators; LAV-HTLV-III; Life; Life Experience; Link; Lymphadenopathy-Associated Virus; Mediation; Method LOINC Axis 6; Methodology; Negotiating; Negotiation; Orphan; Parents; Policies; Policy Maker; Policy Research; Population; Prevalence; Procedures; Programs (PT); Programs [Publication Type]; Protocol Screening; Psychosocial Assessment and Care; Psychosocial Effect; Public Health; Records; Republic of South Africa; Research; Research Personnel; Researchers; Role; Rural; Sampling; Science; Services; Sight; Site; South Africa; Southern Africa; System; System, LOINC Axis 4; Systematics; Translating; Translatings; Translations; Treatment/Psychosocial Effects; Union of South Africa; Virus-HIV; Vision; Work; access to services; access to treatment; availability of services; base; beneficiary; children; coping; design; designing; effective intervention; enroll; ethnographic; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; interventional strategy; language translation; programs; psychosocial assessment; psychosocial care; psychosocial studies; psychosocial support; public health medicine (field); public health relevance; response; social; social role; youngster","Vulnerability, Eligibility, and the ""OVC"": Local Lives of Policies and Categories",,84714,ZRG1,Special Emphasis Panel,,2,41380,
7771642,F31,MH,5,,02/06/2010,02/05/2011,PA-07-002,5F31MH084765-02,,NIMH:41176;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KONDA, KELIKA ANNE;",9286779;,5F31MH084765,02/06/2009,02/05/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Alcohols; Behavior; Bisexual; Chemical Class, Alcohol; Chlamydia; Cities; Communities; Computer Programs; Computer software; Condom; Condoms, Unspecified; Data; Diffusion of Innovation; Drug usage; Drugs; Effectiveness of Interventions; Epidemic; Ethnography; Female; Gays; General Population; General Public; Goals; Gonococcal Infection; Gonorrhea; Government; Group Identifications; HHV-2; HIV; HSV-2; HSV2; HTLV-III; Herpes Simplex Virus 2; Herpes Simplex Virus Type 2; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus progenitalis; High-Risk Sex; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human herpes simplex virus type 2; Identifications, Group; Institutes; International; Intervention; Intervention Strategies; LAV-HTLV-III; Laboratories; Lead; Low income; Lymphadenopathy-Associated Virus; Medication; Miyagawanella; NIMH; NRSA; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Research Service Awards; Parents; Pb element; Peru; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prevalence; Prevalence Study; Preventive Intervention; Reporting; Research; Research Resources; Resources; Risk; Risk Behaviors; Risky Behavior; Role; STD; SUBGP; Sex Behavior; Sexual Activity; Sexual Behavior; Sexual Partners; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Site; Software; Study, Prevalence; Subgroup; Survey Instrument; Surveys; Syphilis; Testing; Training; Underemployment; Unemployment; United States National Institute of Mental Health; Unprotected Sex; Unsafe Sex; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Woman; Work; aged; at risk behavior; base; bedsonia; community intervention; computer program/software; condoms; disease prevention; disease risk; disorder prevention; disorder risk; drug use; drug/agent; effect of intervention; efficacy testing; efficacy trial; ethnographic; gang; great pox; heavy metal Pb; heavy metal lead; herpes simplex ii; high risk; high risk men; human alphaherpesvirus 2; intervention effect; interventional strategy; jobless; joblessness; male; men; men at high risk; men who have sex with men; men who have sex with other men; men's; out of work; outreach; peer; preventional intervention strategy; public health relevance; response; sex; sex activity; sex partner; sex risk; social role; statistical center; theories; underemployed; unemployed","NIMH Collaborative HIV/STD Prevention Trial among young, low-income men in Peru",,84765,ZRG1,Special Emphasis Panel,,2,41176,
7776975,F31,NR,5,,02/16/2010,10/15/2011,PAR-05-091,5F31NR010176-03,,NINR:38014;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,CHICAGO,UNITED STATES,OTHER HEALTH PROFESSIONS,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"GARFIELD, LINDSEY ;",8632000;,5F31NR010176,08/16/2007,10/15/2011,"0-11 years old; 21 year old; Accounting; Aeroseb-HC; Affect; Age; Aggression; Aggressive behavior; Anxiety; Behavior; Biologic Marker; Biological; Biological Factors; Biological Markers; Brain; Breast Feeding; Breastfeeding; Cardiovascular Diseases; Caring; Cessation of life; Cetacort; Chemotherapy-Hormones/Steroids; Child; Child Youth; Children (0-21); Circulatory Collapse; Clinical; Clinical Research; Clinical Study; Conflict; Conflict (Psychology); Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Data; Death; Depression; Depression, Postpartum; Dermacort; Detection; Diagnosis; Diagnostic; Diagnostic Findings; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Early Diagnosis; Eldecort; Emotional Depression; Emotions; Encephalon; Encephalons; Endocrine Gland Secretion; Enrollment; Environment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Equilibrium; FLR; Face; Factor, Biologic; Failure (biologic function); Foundations; Funding; Genetic; Goals; Growth and Development; Growth and Development function; HPA; Health; Health behavior; Hormones; Human, Child; Hydrocortisone; Hydrocortone; Hytone; Illinois; Immune system; Infant; Infant Care; Infant, Very Low Birth Weight; Infanticide; Intensive Care Units, Neonatal; Investigators; Killings; Knowledge; Lactation; Link; Literature; Logistic Regressions; Major Depressive Disorder; Maternal Behavior; Measures; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mental Depression; Modeling; Molecular Marker; Mothers; Murder; NIH; National Institute of Nursing Research; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Negotiating; Negotiation; Neonatal Intensive Care Units; Nervous System, Brain; Neuroendocrine; Neuroendocrine System; Neurohypophysis; Neurosecretory Systems; Newborn Intensive Care Units; Nurses; Nutracort; OXT; Ocytocin; Organism-Level Process; Organismal Process; Outcome; Oxytocin; Pain; Painful; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Parenting; Parenting behavior; Personnel, Nursing; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Pituitary Gland, Posterior; Post-Natal Depression; Post-Partum Depression; Posterior Lobe of the Pituitary Gland; Posterior Pituitary Gland; Postnatal Depression; Postpartum; Postpartum Depression; Postpartum Period; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Procedures; Process; Proctocort; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Questionnaires; Recombinant Oxytocin; Regressions, Logistic; Regulation; Reporting; Research; Research Personnel; Research Proposals; Research Specimen; Research Training; Researchers; Risk; Role; Rosemary; Shock; Signature Molecule; Signs and Symptoms; Specimen; Stress; Stressful Event; Structure of paraventricular nucleus; Suicide; Symptoms of depression; Therapeutic Hormone; Therapeutic Hydrocortisone; Touch; Touch sensation; United Kingdom; United States; United States National Institutes of Health; Universities; Very Low Birth Weight Infant; Weight; Woman; acute stress; balance; balance function; base; biomarker; biopsychosocial; body system, allergic/immunologic; cardiovascular disorder; career; children; circulatory shock; depressive; depressive symptoms; design; designing; early detection; enroll; experience; experiment; experimental research; experimental study; facial; failure; fatal attempt; fatal suicide; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; infant health care; innovate; innovation; innovative; instrument; intent to die; major depression; organ system, allergic/immunologic; paraventricular nucleus; physiologic model; posterior lobe of pituitary; posterior pituitary; programs; psychologic; psychological; psychosocial; research study; response; salivary assay; skills; social; social role; stressor; suicidality; twenty-one year old; very low birth weight infant human; youngster",Postpartum Depressive Symptoms: A Search for a Biologic Marker,,10176,NRRC,National Institute of Nursing Research Initial Review Group,,3,38014,
7771802,F31,NR,5,,02/20/2010,02/19/2011,PA-05-091,5F31NR010453-03,,NINR:28268;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,CHESTNUT HILL,UNITED STATES,PSYCHIATRY,04,045896339,US,MA,02467,BOSTON COLLEGE,"HANNON-ENGEL, SANDRA L.;",8770548;,5F31NR010453,02/20/2008,02/19/2011,"12-20 years old; Adolescence; Area; Behavior; Binge Eating; Blood Plasma; Bulimia; Bulimias; CCK; Cell Communication and Signaling; Cell Signaling; Characteristics; Cholecystokinin; Chronic; Clinical Investigator; Complex; Disease; Disease remission; Disorder; Eating Disorders; Foundations; Future; Generalized Growth; Growth; Individual; Ingestion; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knowledge; Liquid substance; Measurement; Nervosa, Bulimia; Pancreozymin; Peptide Signal Sequences; Persons; Physiologic; Physiological; Plasma; Population; RMSN; Remission; Research; Reticuloendothelial System, Serum, Plasma; Role; Satiation; Satiations; Serum, Plasma; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Tissue Growth; Training; Uropancreozymin; adolescence (12-20); biobehavior; biobehavioral; biological signal transduction; comparative; compulsive eating; compulsive feeding; compulsive overeating; design; designing; disease/disorder; fluid; interest; interventional strategy; liquid; ontogeny; prospective; protein signal sequence; psychologic; psychological; response; satiety; skills; social role; teenage",Role of Altered CCK Response in Bulimia Nervosa,,10453,NRRC,National Institute of Nursing Research Initial Review Group,,3,28268,
7761717,F31,NS,5,,02/01/2010,01/31/2011,PA-00-069,5F31NS056462-04,,NINDS:28380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,PHARMACOLOGY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"COCAS, LAURA A;",8101065;,5F31NS056462,02/01/2007,01/31/2011,"21+ years old; Adult; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Cadherins; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cell surface; Cell/Tissue, Immunohistochemistry; Cells; Cellular Morphology; Characteristics; Corpus Striatum; Corpus striatum structure; Defect; Development; Dorsal; ER81; ETV1; ETV1 gene; Embryo; Embryonic; Event; Family; Gene Expression; Gene Family; Generations; Genes; Genetic; Genetic Markers; Genetics, in situ Hybridization; Human, Adult; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Lateral; Limbic System; Liver Cell Adhesion Molecules; Maintenance; Maintenances; Mammals, Mice; Mice; Mice, Transgenic; Murine; Mus; Neural Stem Cell; Nuclear Structure; Pattern; Play; Reading; Regulation; Role; Side; Source; Stream; Striate Body; Striatum; Structure; Telencephalon; Transgenic Mice; adult human (21+); amygdaloid nuclear complex; cell morphology; cell sorting; cell type; in situ Hybridization Staining Method; insight; liver cell adhesion molecule; loss of function; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; postnatal; social role; striatal; transcription factor",Genetic Interactions at the Cortical Striatal Border,,56462,ZRG1,Special Emphasis Panel,,4,28380,
7767665,F31,NS,5,,02/01/2010,01/31/2011,,5F31NS058097-02,,NINDS:41380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,BIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"YAMAUCHI, KEN ;",8632157;,5F31NS058097,02/01/2009,01/31/2011,"Actins; Address; Axon; BMP-2; BMP-2A; BMP2; BMP7; BMP7 gene; BMPR-II; BMPR2; BRK-3 protein; Behavior; Binding; Binding (Molecular Function); Bone Morphogenetic Protein 7 Gene; Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase); Bone Morphogenetic Proteins; Brain; Bypass; Cell Communication and Signaling; Cell Signaling; Cellular Matrix; Central Nervous System; Cues; Cytoskeletal System; Cytoskeleton; Development; EC 2.7; Embryo; Embryonic; Encephalon; Encephalons; Environment; FLR; Failure (biologic function); Goals; Intracellular Communication and Signaling; Kinases; Knockout Mice; Knowledge; LIMK; LIMK1; LIMK1 gene; Lead; Ligand Binding; Mediating; Medulla Spinalis; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Myelopathy, Traumatic; Nature; Nerve Cells; Nerve Unit; Nervous System Physiology; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurites; Neurocyte; Neurologic function; Neurological function; Neurons; Null Mouse; OP1 Gene; Osteogenic Protein 1 Gene; Pathway interactions; Patients; Pb element; Peripheral Nerves; Phosphorylation; Phosphotransferases; Process; Protein Phosphorylation; Proteins; Publications; Receptor Protein; Regulation; Reporting; Role; Scientific Publication; Sensory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Speed; Speed (motion); Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Synapses; Synaptic; Testing; Time; Transphosphorylases; axon growth; axon growth cone guidance; axon guidance; axon regeneration; axonal growth; axonal regeneration; biological signal transduction; bone morphogenetic protein 2; bone morphogenetic protein receptor II; bone morphogenetic protein receptor type II; bone morphogenetic protein receptors; cofilin; failure; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; intervention design; intracellular skeleton; nervous system function; neural circuit; neural circuitry; neuronal; overexpression; pathway; prevent; preventing; receptor; receptor, BMP; receptor, type II BMP; social role; therapy design; treatment design",Role of BMP Chemorepellent Signaling as a Regulator of Axon Outgrowth,,58097,ZRG1,Special Emphasis Panel,,2,41380,
7758752,F31,NS,5,,01/12/2010,01/11/2011,PA-07-002,5F31NS059094-02,,NINDS:22688;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN DIEGO,UNITED STATES,PSYCHOLOGY,53,073371346,US,CA,92182,SAN DIEGO STATE UNIVERSITY,"PARKS, ERIN NICOLE;",8738640;,5F31NS059094,01/12/2009,01/11/2011,"0-11 years old; 21+ years old; 7 year old; Accounting; Adult; Age; Basal Ganglia; Basal Nuclei; Bilateral; Brain; Brain region; Child; Child Youth; Childhood; Children (0-21); Cognitive; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Correlations; Data Set; Dataset; Detection; Development; Diagnosis; Disease Frequency Surveys; Encephalon; Encephalons; Event; Functional Imaging; Functional Magnetic Resonance Imaging; Human, Adult; Human, Child; Image; Individual Differences; Inferior; Judgment; Knowledge; Language; Language Development; Left; Linguistic; Linguistics; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Maps; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Middle Temporal Gyrus; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Parietal Lobe; Parietal Lobe of the Brain; Participant; Pattern; Performance; Physiologic Imaging; Prevention; Process; Publishing; Sampling; Scanning; Semantic; Semantics; Series; Site; Staging; Structure of middle temporal gyrus; System; System, LOINC Axis 4; Techniques; Testing; Time; Work; Zeugmatography; acquiring language skills; adult human (21+); age dependent; age related; base; blood oxygen level dependent; children; cognitive change; comparison group; design; designing; developmental disease/disorder; developmental disorder; expectation; extrastriate; fMRI; imaging; language acquisition; language learning; lexical; neural; neural mechanism; neuromechanism; novel; parietal cortex; pediatric; relating to nervous system; response; seven year old; theories; youngster",Neurodevelopmental plasticity of language:  From bottom-up to top-down,,59094,ZRG1,Special Emphasis Panel,,2,22688,
7776831,F31,NS,5,,02/17/2010,02/16/2011,,5F31NS061589-02,,NINDS:41380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ROCHESTER,UNITED STATES,OTHER HEALTH PROFESSIONS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"RAIKER, STEPHEN ;",9037815;,5F31NS061589,02/17/2009,02/16/2011,"21+ years old; ASY protein, human; Acute; Acylneuraminyl hydrolase; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Adult; Affinity; Anatomic; Anatomical Sciences; Anatomy; Antimorphic mutation; Antisera; Apoplexy; Assay; Attention; Axon; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CHO Cells; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chinese Hamster; Chinese Hamster Ovary Cell; Cholera; Cleaved cell; Complex; Cranial Nerve II; Cranial Nerve II Injuries; Crush Injury; Cytoplasmic Granules; Defect; Degenerative Disorder; Development; Dominant Negative; Dominant Negative Receptor; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsal; Dorsal Root Ganglia; Ectopic Expression; Electron Microscopy; Electrons; Embryo; Embryonic; Enzymes; Exons; FLR; Failure (biologic function); Family; Fiber; GD(1a) ganglioside; GD1a ganglioside; Ganglia, Spinal; Ganglion Cells (Retina); Gangliosides; Gene Family; Generalized Growth; Genes; Genetic; Genetics, in situ Hybridization; Genital System, Female, Ovary; Glia; Glial Cells; Goals; Growth; Hamster, Chinese; Human, Adult; Immune Sera; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Situ Hybridization; In Vitro; Injury; Intracellular Communication and Signaling; Knockout Mice; Kolliker's reticulum; LRR protein; Laboratories; Length; MAG Protein; MOG glycoprotein; Maintenance; Maintenances; Mammals, Mice; Maps; Mediating; Medulla Spinalis; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Myelin; Myelin Associated Glycoprotein; Myelin Proteins; Myelin Sheath; Myelopathy, Traumatic; N-Acetylneuraminic Acids; N-Acylneuraminate Glycohydrolases; NRVS-SYS; Natural regeneration; Negative Beta Particle; Negatrons; Neonatal; Nerve Cells; Nerve Crush; Nerve Regeneration; Nerve Unit; Nervous; Nervous System; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraminidase; Neuraxis; Neurite Growth Inhibitor 220; Neurite Outgrowth Inhibitor; Neurites; Neurocyte; Neuroendocrine-Specific Protein C Like (foocen); Neuroglia; Neuroglial Cells; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurological Damage; Neurological Injury; Neurological trauma; Neurons; Nogo-A; Non-neuronal cell; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oligosaccharide Sialidase; Optic Nerve; Optic Nerve Injuries; Optic Nerve Trauma; Optic Neuropathy, Traumatic; Ovary; Pattern; Peripheral Nervous System; Play; Pleural Glycoproteins; Population; Proteins; Public Health; RTN-x protein, human; RTN4 protein, human; Receptor Protein; Regeneration; Reporter; Reporting; Reticulon 4; Retina; Retinal Ganglion Cells; Role; Sciatic Nerve; Science of Anatomy; Second Cranial Nerve; Second Cranial Nerve Injuries; Second Cranial Nerve Trauma; Sialic Acids; Sialidase; Sialoglycoproteins; Sialoglycosphingolipids; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Spinal Cord Trauma; Spinal Ganglia; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stroke; Structure; Structure of sciatic nerve; Synaptic plasticity; Testing; Therapeutic; Therapeutic Agents; Time; Tissue Growth; Trauma, Brain; Trauma, Nervous System; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Work; Yin; adeno vector; adenovector; adult animal; adult human (21+); age dependent; age related; anatomy; attenuation; axon growth; axon regeneration; axonal growth; axonal regeneration; axonal sprouting; biological signal transduction; brain attack; cell growth; cell type; cerebral vascular accident; cleaved; combinatorial; degenerative condition; degenerative disease; dorsal root ganglion; exo alpha sialidase; experiment; experimental research; experimental study; failure; gangliocyte; ganglion cell; ganglioside, GD1a; gene product; granule; human RTN4 protein; in situ Hybridization Staining Method; in vivo; inhibitor; inhibitor/antagonist; insight; interest; lens; leucine-rich repeat protein; mature animal; member; membrane structure; monolayer; mouse mutant; mutant; myelin glycoprotein; myelin oligodendrocyte glycoprotein; myelination; nerve cement; nervous system regeneration; neural; neural regeneration; neuronal; oligodendrocyte-myelin glycoprotein; ontogeny; optic nerve regeneration; overexpression; postnatal; protein expression; public health medicine (field); receptor; regenerate; regenerative; relating to nervous system; research study; reticulon 4 protein, human; retinal ganglion; sciatic nerve; social role; spinal tract; stroke; traumatic brain damage",Characterization of the Myelin-Associated Glycoprotein Receptor NgR2 in vivo,,61589,ZRG1,Special Emphasis Panel,,2,41380,
7781315,F31,NS,5,,02/12/2010,02/11/2011,PA-07-002,5F31NS062615-02,,NINDS:33058;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"CHANG, MINDY ;",9155496;,5F31NS062615,02/12/2009,02/11/2012,"Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Area; Articulation; Attention; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Automobile Driving; Behavior; Behavioral; Behavioral Paradigm; Blindness; Brain; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive; Communication; Complex; Coupling; Cues; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Detection; Disease; Disorder; Drivings, Automobile; Electrodes; Electrodes, Miniaturized; Encephalon; Encephalons; Environment; Epilepsy; Epileptic Seizures; Epileptics; Exhibits; Eye Movements; Fixation; Frequencies (time pattern); Frequency; Idiopathic Parkinson Disease; Intracellular Communication and Signaling; Joints; Kanner's Syndrome; Lewy Body Parkinson Disease; Link; Location; Macaca; Macaque; Measures; Mediating; Memory; Methods; Metric; Microelectrodes; Monkeys; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Organism; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Performance; Peripheral; Phase; Play; Prefrontal Cortex; Preparation; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Pursuit, Saccadic; Relative; Relative (related person); Research; Role; Saccades; Saccadic Eye Movements; Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Seizure Disorder; Selective inattention; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Structure; System; System, LOINC Axis 4; Task Performances; Testing; Time; Training; Visual; Visual Cortex; Visual attention; Visuospatial; area V4; awake; base; biological signal transduction; biomarker; cognitive function; dementia of the Alzheimer type; dementia praecox; directed attention; directs attention; disease/disorder; driving; epilepsia; epileptiform; epileptogenic; extrastriate; extrastriate visual cortex; frontal eye fields; human subject; insight; living system; nervous system disorder; neural; neural mechanism; neural patterning; neurological disease; neuromechanism; neuronal; neurophysiology; ocular motor; ocularmotor; oculomotor; primary degenerative dementia; relating to nervous system; response; sample fixation; schizophrenic; selective attention; senile dementia of the Alzheimer type; social role; visual cortical; visual information; visual process; visual processing; visual spatial; visual stimulus",Network Level Neural Mechanisms in Visual Attention,,62615,ZRG1,Special Emphasis Panel,,2,33058,
7782804,F31,NS,5,,02/12/2010,02/11/2011,PA-07-002,5F31NS065607-02,,NINDS:30563;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEWARK,UNITED STATES,NEUROSCIENCES,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"ZIEGLER, AMBER N;",9543005;,5F31NS065607,02/12/2009,02/11/2012,"21+ years old; Adult; Adverse effects; Affect; Autoregulation; Brain; Cell Growth and Maintenance; Cell Maintenance; Cells; Cellular Expansion; Cellular Growth; Culture Media; Data; Development; Dose; Encephalon; Encephalons; Exercise; Exercise, Physical; Future; Generalized Growth; Goals; Growth; Growth and Development; Growth and Development function; Homeostasis; Human, Adult; Humulin R; IGF; IGF Receptor; IGF-1 Receptor; IGF1; IGF1 gene; IGF1R; IGF2; IGF2 gene; IGFI; INSR; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Insulin-Like Growth Factor 1 Receptor; Insulin-Like Growth Factor Receptor; Insulin-Like Growth Factors; Insulin-Like-Growth Factor I Receptor; Ligands; Maintenance; Maintenances; Mother Cells; Nervous System Diseases; Nervous System, Brain; Neural Growth; Neural Stem Cell; Neurologic Disorders; Neurological Disorders; Neuronal Growth; Novolin R; Pathway interactions; Physiological Homeostasis; Play; Progenitor Cells; Receptor Protein; Receptor Signaling; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Receptors, Somatomedin; Role; Somatomedins; Stem cells; Sulfation Factor; System; System, LOINC Axis 4; Therapeutic; Therapeutic Uses; Tissue Growth; Treatment Side Effects; adult human (21+); analog; cell growth; growth media; in vivo; insulinlike growth factor; nerve stem cell; nervous system disorder; neural progenitor cells; neurogenesis; neurological disease; neuronal progenitor; neuronal progenitor cells; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; pathway; receptor; self-renewal; side effect; social role; stem cell population; therapy adverse effect; treatment adverse effect",IGF2 and neural stem cell homeostasis,,65607,ZRG1,Special Emphasis Panel,,2,30563,
7792332,F31,NS,5,,02/23/2010,02/22/2011,PA-07-106,5F31NS065698-02,,NINDS:41380;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BRONX,UNITED STATES,NEUROSCIENCES,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"PENZO, MARIO A;",9198906;,5F31NS065698,02/23/2009,02/22/2011,"Address; Afferent Pathways; Agonist; Anterior Quadrigeminal Body; Auditory; Aves; Avian; Axon; Behavior; Birds; Blood Coagulation Factor IV; Ca++ element; Calcium; Cannabinoids; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chickens; Coagulation Factor IV; Corpora quadrigemina, superior colliculus; Cues; Data; Dendrites; Endocannabinoids; Factor IV; Feedback; Frequencies (time pattern); Frequency; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Glutamate Receptor; Glutamates; Goals; Inferior Colliculus; Intracellular Communication and Signaling; Knowledge; L-Glutamate; Lead; Learning; Life; Light; Location; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Synaptic Depression; Mammalia; Mammals; Mammals, General; Mediating; Memory; Mesencephalon; Metabotropic Glutamate Receptors; Method LOINC Axis 6; Methodology; Mid-brain; Midbrain; Midbrain structure; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleus; Optic Tectum; Pb element; Photoradiation; Play; Posterior Quadrigeminal Body; Process; Receptor Activation; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Reporting; Role; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Column; Spine; Superior Colliculus; Synapses; Synaptic; Synaptic plasticity; Tectums, Optic; Vertebral column; backbone; base; biological signal transduction; cannabinoid receptor; experience; heavy metal Pb; heavy metal lead; long term depression; neuronal; postsynaptic; presynaptic; response; social role; superior colliculus Corpora quadrigemina; visual feedback; visual information; visual tectum",Endocannabinoid-mediated long-term depression in the avian inferior colliculus,,65698,ZRG1,Special Emphasis Panel,,2,41380,
7807029,F32,AG,5,,01/05/2010,01/04/2011,,5F32AG029064-02,,NIA:52154;,2010,NATIONAL INSTITUTE ON AGING,,SEATTLE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"NELSON, FRANK E;",8509364;,5F32AG029064,01/05/2009,01/04/2012,"21+ years old; Adult; Affect; Age; Aged 65 and Over; Arts; Biomechanics; Clinical; Coupling; Development; Dorsal; Dysfunction; Elderly; Elderly, over 65; Elements; Employee Strikes; Exercise; Exercise, Physical; Functional disorder; Goals; Hand; Human; Human, Adult; Human, General; Individual; Intervention; Intervention Strategies; Laboratories; Left; Magnetic Resonance; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanics; Methods; Methods and Techniques; Methods, Other; Mitochondria; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Myocytes; Optics; Performance; Physical Health Services / Rehabilitation; Physiopathology; Property; Property, LOINC Axis 2; Randomized; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Role; Strikes; Strikes, Employee; System; System, LOINC Axis 4; Techniques; Testing; Time; Training; Work; adult human (21+); advanced age; age dependent; age related; base; disability; elders; experiment; experimental research; experimental study; functional loss; geriatric; improved; in vivo; innovate; innovation; innovative; interventional strategy; late life; later life; mitochondrial; mitochondrial dysfunction; muscle aging; new approaches; novel; novel approaches; novel strategies; novel strategy; older adult; older person; pathophysiology; randomisation; randomization; randomly assigned; rehabilitative; research study; senior citizen; social role; strength training; tool",Inefficiency in Aging Muscle: Causes and Rehabilitation,,29064,ZRG1,Special Emphasis Panel,,2,52154,
7921543,F32,AG,5,,03/09/2010,01/08/2011,,5F32AG034019-02,,NIA:43370;,2010,NATIONAL INSTITUTE ON AGING,,BAR HARBOR,UNITED STATES,,02,042140483,US,ME,046091500,JACKSON LABORATORY,"ACKERT-BICKNELL, CHERYL ;",8826348;,5F32AG034019,03/09/2009,03/08/2011,"Address; Age; Aging; American; Animal Model; Animal Models and Related Studies; Apoplexy; Bio-Informatics; Bioinformatics; Blood Serum; Bone; Bone Density; Bone Mineral Density; Bone and Bones; Bones and Bone Tissue; Cancer of Breast; Candidate Disease Gene; Candidate Gene; Cardiac infarction; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chromosome 2; Chromosome Mapping; Chromosome Substitution Strain; Chromosomes, Human, Pair 2; Clinical Trial Overviews; Comparative Genomic Analysis; Complex; Congenic Strain; Consomic Strain; Consomic Strain/Chromosome Substitution Strain; Data; Data Banks; Data Bases; Data Pooling; Data Poolings; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disorder; Female; Fracture; Fracture due to osteoporosis; Future; GWAS; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic analyses; Genetics, Gene Mapping; Genome; Goals; HDL Cholesterol; Haplotypes; High Density Lipoprotein Cholesterol; Human; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Inbred Strain; Inbred Strains Mice; Incidence; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Lead; Length of Life; Linkage Mapping; Lipoproteins, HDL Cholesterol; Location; Longevity; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measurable; Meta-Analyses; Meta-Analysis; Methods and Techniques; Methods, Other; Mice; Mice, Inbred Strains; Modeling; Molecular; Murine; Mus; Myocardial Infarct; Myocardial Infarction; Osteoporosis; Osteoporosis with fracture; Osteoporotic fracture; Pathway interactions; Pb element; Phenotype; QTL; Quantitative Trait Loci; Research; Research Resources; Resources; Risk; Role; SNP Map; Senescence; Serum; Single Nucleotide Polymorphism Map; Somatomedin C; Stroke; Techniques; Testing; Vascular Accident, Brain; Woman; age dependent; age related; alpha-Lipoprotein Cholesterol; base; bone; bone fracture; bone geometry; bone mass; bone strength; brain attack; cardiac infarct; cerebral vascular accident; clinical data repository; clinical data warehouse; congenic; consomic; coronary attack; coronary infarct; coronary infarction; data repository; density; disease/disorder; gene discovery; gene interaction; genetic analysis; genetic mapping; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; human data; improved; life span; lifespan; malignant breast neoplasm; model organism; osteoporosis with pathological fracture; pathway; prevent; preventing; public health relevance; relational database; senescent; social role; stroke; tool; trait; whole genome association studies; whole genome association study","Examination of Co-inheritance of Bone Mineral Density, IGF-1 and Lifespan",,34019,ZRG1,Special Emphasis Panel,,2,43370,
7736804,F32,AI,5,,11/14/2009,11/13/2010,PA-06-373,5F32AI068531-03,,NIAID:53354;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,,08,099992430,US,CA,94158,J. DAVID GLADSTONE INSTITUTES,"KAUDER, STEVEN E;",6709278;,5F32AI068531,11/14/2007,11/13/2010,"AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; Acetylation; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Anti-HIV Positivity; Anti-Retroviral Agents; Antimorphic mutation; Antiretroviral Agents; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Models; CHIP assay; Cell Line; Cell Lines, Strains; CellLine; Cells; Centromere; Cessation of Treatment; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Structure; Chromosome 7; Chromosomes, Human, Pair 7; Combining Site; DNA; DNA Integration; Data; Deoxyribonucleic Acid; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drugs; Elements; Enhancers; Enzymes; Eu-HMTase1; Fluorescence; GFP; Gene Down-Regulation; Gene Expression; Gene Transcription; Genes; Genes, nef; Genetic Transcription; Genome; Genome, Human; Green Fluorescent Proteins; HDAC; HDAC Proteins; HIV; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV-3'-orf Genes; HTLV-III; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Heterochromatin; Histone Deacetylase; Histone H3; Histone H3.3; Histones; Human; Human Genome; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Hypermethylation; In Vitro; Individual; Jurkat Cells; L-Lysine; LAV-HTLV-III; Laboratories; Latent Virus; Lymphadenopathy-Associated Virus; Lysine; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Methylation; Model System; Modeling; Models, Biologic; Modification; Molecular; Molecular Interaction; Monitor; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Polycomb; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Proteins; Proviruses; Public Health; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RT-PCR; RTPCR; Reactive Site; Recombinants; Refractory; Reporter; Repression; Reverse Transcriptase Polymerase Chain Reaction; Role; Sequence-Specific Posttranscriptional Gene Silencing; Site; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Testing; Transcription; Transcription Corepressor; Transcription Regulation; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; United States; Variant; Variation; Virus; Virus-HIV; Viruses, General; Withholding Treatment; anti-retroviral; antibody positive AIDS test; antigen positive AIDS test; antiretroviral; antiretroviral therapy; chromatin immunoprecipitation; chromatin modification; cultured cell line; cytokine; demethylation; drug/agent; euchromatic histone methyltransferase 1; experiment; experimental research; experimental study; gene product; gene repression; histone H3 methyltransferase; histone methylase; histone methyltransferase; histone modification; in vitro Model; inhibitor; inhibitor/antagonist; intervention development; nef Genes; public health medicine (field); research study; response; reverse transcriptase PCR; seropositive (AIDS test); small molecule; social role; theories; therapy development; treatment development",Chromatin Dynamics in a Model of Latent HIV Infection,,68531,AMCB,AIDS Molecular and Cellular Biology Study Section,,3,53354,
7761780,F32,AI,5,,02/01/2010,01/31/2011,PA-07-107,5F32AI072996-03,,NIAID:52154;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BERKELEY,UNITED STATES,ENGINEERING (ALL TYPES),09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"MILLER-JENSEN, KATHRYN ;",8631310;,5F32AI072996,02/01/2008,01/31/2011,"3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip- erazinyl)- 2(1H)-quinolinone; 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Affect; Arkin; Arkin-Z; Binding; Binding (Molecular Function); Cell Communication and Signaling; Cell Signaling; Cells; Computational Biology; Computational Technique; Computer Simulation; Computerized Models; Computing Methodologies; Data; Drug Design; Drugs; Environment; Exhibits; Feedback; Figs; Figs - dietary; Gene Expression; Gene Transcription; Genes, Viral; Genetic Transcription; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Heterogeneity; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Immunoglobulin Enhancer-Binding Protein; Individual; Infection; Intracellular Communication and Signaling; Jurkat Cells; LAV-HTLV-III; Laboratories; Lead; Lymphadenopathy-Associated Virus; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Medication; Modeling; Models, Computer; Molecular; Molecular Biology Techniques; Molecular Interaction; Molecular Virology; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pieranometazine; Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr- o -2-oxo-6-quinolinyl); Population; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA Expression; Scientist; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; System; System, LOINC Axis 4; T memory cell; T-Cells; T-Lymphocyte; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Training; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Vesnarinone; Viral; Viral Genes; Viral Latency; Virus; Virus Latency; Virus-HIV; Viruses, General; base; biological signal transduction; computational methodology; computational methods; computational modeling; computational models; computational simulation; computer based models; computer methods; computerized modeling; computerized simulation; design; designing; drug/agent; efficacy testing; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; in silico; intervention design; kappa B Enhancer Binding Protein; latent infection; mathematical model; mathematical modeling; memory T lymphocyte; novel; nuclear factor kappa beta; public health relevance; purge; purging; research study; therapy design; thymus derived lymphocyte; treatment design; virtual simulation",Quantitative Analysis of Cellular Signaling in Viral Latency,,72996,ZRG1,Special Emphasis Panel,,3,52154,
7779488,F32,AI,5,,02/01/2010,01/31/2011,,5F32AI074245-03,,NIAID:52154;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CAMBRIDGE,UNITED STATES,BIOLOGY,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"SOHN, JUNGSAN ;",8741132;,5F32AI074245,02/01/2008,01/31/2011,"Affect; Alanine; Alanine, L-Isomer; Amino Acids; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; C-terminal; Cancer Treatment; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cleaved cell; Crystallographies; Crystallography; Cytoplasmic Domain; Cytoplasmic Tail; DNA Sequence Rearrangement; Diffuse; E coli; Escherichia coli; Esteroproteases; Event; Genes, LacZ; Genetic; Gram-Negative Bacteria; In Vitro; Intracellular Communication and Signaling; L-Alanine; LacZ; LacZ Genes; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Membrane; Modeling; Molecular; Molecular Interaction; Monitor; Mutagenesis, Site-Directed; Oncogenesis; Ortholog; Orthologous Gene; Pathway interactions; Peptidases; Peptide Hydrolases; Peptides; Periplasmic Space; Physiologic; Physiological; Play; Process; Property; Property, LOINC Axis 2; Proteases; Protein Cleavage; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Reaction; Rearrangement; Reporter; Research; Role; Scanning; Series; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Targeted DNA Modification; Targeted Modification; Testing; Triad; Triad Acrylic Resin; Triad resin; Variant; Variation; Virulence; Work; aminoacid; aminoacid sequence of peptide; aminoacid sequence of protein; anti-microbial; anti-microbial agent; anti-microbial drug; anticancer therapy; antimicrobial; antimicrobial agent; antimicrobial drug; base; biological adaptation to stress; biological signal transduction; cancer therapy; cleaved; design; designing; gene product; in vivo; malignancy; membrane structure; monomer; mutant; neoplasm/cancer; novel; pathogenic bacteria; pathway; peptide sequence; periplasm; periplasmic; pore forming protein; porin; protein aminoacid sequence; reaction; crisis; social role; stress response; stress; reaction; tumorigenesis",DegS protease and initiation of the envelope-stress response,,74245,ZRG1,Special Emphasis Panel,,3,52154,
7756592,F32,AI,5,,02/01/2010,01/31/2011,PA-07-107,5F32AI077177-03,,NIAID:50474;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"AGARD, NICHOLAS J.;",8935072;,5F32AI077177,02/01/2008,01/31/2011,"Accounting; Address; Amines; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Aspartate; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase 3, Apoptosis-Related Cysteine Protease; Caspase-1; Cell Death, Programmed; Cell Fraction; Cell-Death Protease; Cells; Cleaved cell; Cysteine Protease CPP32; Disease; Disorder; EC 3.4.22.36; Engineering; Engineerings; Enzymes; Esteroproteases; Event; Family; Goals; ICE Protease; ICE-like protease; IFN-gamma-Inducing Factor; IGIF; IL-1 Gamma; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-18; IL-1b Converting Enzyme; IL-1g; IL18 Protein; IL1B-Convertase; IL1BC; IL1F4; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; In Vitro; Inflammatory; Interferon-gamma-Inducing Factor; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1 Gamma; Interleukin-18; Interleukin-18 Precursor; Interleukin-1beta Converting Enzyme; Jurkat Cells; L-Aspartate; MGC12320; Maps; Mass Spectrum; Mass Spectrum Analysis; Method LOINC Axis 6; Methodology; Methods; Natural Immunity; P45; PARP Cleavage Protease; Peptidases; Peptide Hydrolases; Peptides; Photometry/Spectrum Analysis, Mass; Process; Proteases; Protein Cleavage; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Proteomics; Public Health; Role; SCA-1; SREBP Cleavage Activity 1; Secretory Granules; Secretory Vesicles; Signal Pathway; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stimulus; Substrate Specificity; Testing; Unpublished Works (PT); Unpublished Works [Publication Type]; Yama; Yama protein; base; caspase; caspase-3; cleaved; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytokine; d-Numb; disease/disorder; experiment; experimental research; experimental study; extracellular; gene product; host response; immunoresponse; new therapeutics; next generation therapeutics; novel therapeutics; numb protein; public health medicine (field); research study; social role; subtiligase; unpublished works",Global Analysis of Proteolysis in the Innate Immune Response,,77177,ZRG1,Special Emphasis Panel,,3,50474,
7752475,F32,AI,5,,02/05/2010,02/04/2011,PA-07-107,5F32AI077268-03,,NIAID:52154;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"DAVIS, PAUL H;",8969644;,5F32AI077268,02/05/2008,02/04/2011,"Assay; Attenuated; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological; Biological Assay; Biology; Body Tissues; Chronic; Communicable Diseases; Complement; Complement Proteins; Coupled; Cyst; DISSEC; Data; Defect; Development; Disease; Disorder; Dissection; Drug Design; Drugs; Engineered Gene; EngineeredGene; Engineering; Engineerings; Ensure; Fellowship; Focus Groups; GWAS; Gene Targeting; Generalized Growth; Genes; Genetic; Genomics; Goals; Growth; Human; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Knock-out; Knockout; Lead; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Molecular; NRSA; National Research Service Awards; Organism; Parasites; Pathogenesis; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Process; Proteins; Regulation; Research; Role; Staging; System; System, LOINC Axis 4; T. gondii; Targetings, Gene; Techniques; Testing; Therapeutic; Tissue Growth; Tissues; Toxoplasma gondii; Training; Transcript; Transfection; Transgenic Organisms; Vaccines; Validation; Work; base; disease/disorder; drug/agent; experiment; experimental research; experimental study; fitness; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; immunosuppressed patient; in vivo; insight; interest; living system; mutant; novel; ontogeny; research study; skills; social role; transgenic; vector; whole genome association studies; whole genome association study",Molecular Dissection of Early Toxoplasma gondii Bradyzoite Differentiation,,77268,ZRG1,Special Emphasis Panel,,3,52154,
7779387,F32,AI,5,,03/01/2010,02/28/2011,,5F32AI081483-02,,NIAID:50054;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"SHAKHNOVICH, ELIZABETH ALEXANDRA;",9416603;,5F32AI081483,03/01/2009,02/29/2012,"Address; Area; Assay; Attenuated; Autoregulation; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Blotting, Northern; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chaperone; Code; Coding System; Data; Development; Diarrhea; E coli; EHEC; EHEC, Escherichia coli; Enterohemorrhagic E coli; Enterohemorrhagic E. coli; Enterohemorrhagic E.coli; Enterohemorrhagic Escherichia coli; Enterohemorrhagic strain of E coli; Enterohemorrhagic strain of E. coli; Enterohemorrhagic strain of Escherichia coli; Escherichia coli; Escherichia coli EHEC; Fe element; Functional RNA; Gasser's Syndrome; Gene Expression; Gene Expression Profile; Gene Fusion; Gene Products, RNA; Generalized Growth; Genes; Genetic Screening; Genome; Goals; Growth; Hemolytic-Uremic Syndrome; Homeostasis; Human; Human, General; In Vitro; Intestinal; Intestines; Iron; Knowledge; Laboratories; Lead; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Molecular Chaperones; Non-Coding; Non-Coding RNA; Northern Blotting; Northern Blottings; Pathogenesis; Pathogenicity; Pathogenicity Factors; Pb element; Phenotype; Physiological Homeostasis; Play; Process; Prokaryotae; Prokaryotic Cells; Proteins; RNA; RNA blot analysis; RNA blotting; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Noncoding; RNA, Nontranslated; RNA, Untranslated; Regulation; Ribonucleic Acid; Role; S. enterica; STEC; Salmonella enterica; Shiga toxin-producing E coli; Shiga toxin-producing E. coli; Shiga toxin-producing E.coli; Shiga toxin-producing Escherichia coli; Small RNA; Sound; Sound - physical agent; Subcellular Process; Testing; Tissue Growth; Untranslated RNA; V. cholerae; V.cholerae; Vibrio cholerae; Vibrio comma; Virulence; Virulence Factors; Work; Y. enterocolitica; Y.enterocolitica; Yersinia enterocolitica; biological adaptation to stress; bowel; enteric pathogen; food born pathogen; food borne pathogen; food-born; food-borne; foodborn; foodborn pathogen; foodborne; foodborne pathogen; gene expression signature; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; interest; mRNA; mutant; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; pathogen; prokaryote; public health relevance; quorum sensing; reaction; crisis; social role; sound; stress response; stress; reaction; transcriptome",Enterohemorrhagic Escherichia coli virulence regulation by non-coding RNAs,,81483,ZRG1,Special Emphasis Panel,,2,50054,
7776957,F32,AI,5,,02/05/2010,02/04/2011,PA-07-107,5F32AI083041-02,,NIAID:50474;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"SKLAR, JOSEPH G.;",9497452;,5F32AI083041,02/05/2009,02/04/2012,"Anabolism; Attenuated; Biochemical; Biogenesis; Biological Function; Biological Process; Cell Communication and Signaling; Cell Signaling; Cells; Cleaved cell; Data; Drug Delivery; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Epistasis; Epistasis, Genetic; Epistatic Deviation; Esteroproteases; Family; Fe element; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Epistasis; Genetic defect; Genome; Genus Mycobacterium; Growth; Health; Individual; Infection; Interaction Deviation; Intracellular Communication and Signaling; Iron; Laboratories; Light; Lipids; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Maintenance; Maintenances; Mammals, Mice; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods and Techniques; Methods, Other; Mice; Molecular; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Mutation; Mycobacterium; Mycobacterium tuberculosis; Organism; Origin of Life; Pathogenesis; Pathway interactions; Peptidases; Peptide Hydrolases; Phenotype; Photoradiation; Prevalence; Process; Proteases; Protein Cleavage; Proteinases; Proteolysis; Proteolytic Enzymes; Regulation; Relative; Relative (related person); Research Training; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Siderochromes; Siderophores; Sigma Element; Sigma Factor; Sigma Initiation Factor; Sigma Subunit; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; TM Domain; Techniques; Therapeutic Agents; Tissue Growth; Training; Transmembrane Domain; Transmembrane Region; Tuberculosis; Virulence; Work; adipogenesis; attenuation; biological signal transduction; biosynthesis; career development; cell envelope; cleaved; d-Numb; disease control; disorder control; disseminated TB; disseminated tuberculosis; effective therapy; experiment; experimental research; experimental study; extracellular; gene x gene interaction; genetic epistases; genome mutation; in vivo; intervention development; lipid biosynthesis; lipogenesis; living system; member; metalloproteinase (general); mouse model; multi-drug resistant; multidrug resistant; mutant; mycobactins; new therapeutics; next generation therapeutics; novel therapeutics; null mutation; numb protein; ontogeny; pathway; research study; resistant strain; response; social role; therapy development; treatment development; tuberculous spondyloarthropathy",Regulated Intramembrane Proteolysis in Mycobacterium Tuberculosis,,83041,ZRG1,Special Emphasis Panel,,2,50474,
8013361,F32,AR,5,,12/01/2009,11/30/2010,,5F32AR056182-02X1,,NIAMS:7850;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,,UNITED KINGDOM,,,,UK,,,CANCER RESEARCH UK CAMBRIDGE RES INST,"CONNELLY, JOHN THOMAS;",9178913;,5F32AR056182,12/01/2008,11/30/2011,"1,2-Ethanediol; 2-Hydroxyethanol; 2-hydroxyethyl methacrylate; 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester; 4-Hydroxy-Tamoxifen; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; 9-diethylamino-5H-benzo(a)phenoxazine-5-one; Adhesions; Adhesives; Aminoacetic Acid; Area; Arg-Gly-Asp; Arginine; Arginine, L-Isomer; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain; Aspartic Acid; Assay; BUdR; Behavior; Benzoic acid, 3,4,5-trimethoxy-, 4-(acetyloxy)-6,10-dimethyl-3-(1-methylethyl)-11-oxabicyclo(8.1.0)undec-6-en-2-yl ester; Bioassay; Biocompatible Materials; Biologic Assays; Biological Assay; Biomaterials; Biomedical Engineering; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CD34; CD34 gene; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Caliber; Catenin, Beta-1; Cell Communication and Signaling; Cell Density; Cell Function; Cell Growth in Number; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cell-Extracellular Matrix; CellLine; Cells; Cellular Function; Cellular Morphology; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular biology; Centrifugation; Cold-Insoluble Globulins; Complex; Cues; Cultured Cells; Density, Cell; Development; Diameter; Dihydroxyethanes; Dose; ECM; Engineering; Engineerings; Environment; Epidermis; Ethanediols; Ethylene Glycols; Exposure to; Extracellular Matrix; Extracellular Matrix, Integrins; FN1; FNZ; Fibronectin 1; Fibronectins; Fractionation, Centrifugation; Glycine; Goals; HPCA1; Hair Follicle; Hair follicle structure; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Vitro; Integrins; Intracellular Communication and Signaling; Island; K7, keratin; Ker10 protein; Keratin; L-Arginine; L-Aspartic Acid; LETS Proteins; Large External Transformation-Sensitive Protein; Ligands; Malignant Cell; Malignant Skin Neoplasm; Malignant Tumor of the Skin; Mammals, Mice; Measures; Mediating; Melanoma and Non-Melanoma Skin Cancer; Mice; Mice, Transgenic; Monoethylene Glycol; Morphology; Mother Cells; Mouse Strains; Murine; Mus; Oligo; Oligonucleotides; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; PRO2286; Pathology; Pathway interactions; Pattern; Play; Polymer Chemistry; Polymers; Position; Positioning Attribute; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RGD; RGD (peptide); RGD (sequence); RGD Cell Adhesion Domain; RGD Domain; RGD Motif; RGD Tripeptide Sequence; RGD tripeptide; Receptor Protein; Regulation; Research; Research Institute; Research Proposals; Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Stem cells; Subcellular Process; Surface; System; System, LOINC Axis 4; Therapeutic Agents; Transgenes; Transgenic Mice; Transgenic Organisms; Uridine, 5-bromo-2'-deoxy-; Wild Type Mouse; Work; alpha 2-Surface Binding Glycoprotein; arginyl-glycyl-aspartic acid; base; beta catenin; bioengineering; bioengineering/biomedical engineering; biological signal transduction; c myc; c-myc Genes; cancer cell; cell biology; cell morphology; cultured cell line; density; epiligrin; ethylene glycol; experiment; experimental research; experimental study; gene product; glycol methacrylate; hydroxyethyl methacrylate; improved; insight; involucrin; kalinin; keratin 10; keratin 7; keratin-7, K7; keratinocyte; keratinocyte differentiation; laminin-5; light microscopy; loricrin; migration; nicein; nile red; notch; notch protein; notch receptors; novel; para-hydroxytamoxifen; pathway; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; polymerization; receptor; research study; resistant; response; self-renewal; social role; stem cell biology; stem cell differentiation; synthetic peptide; tamoxifen metabolite B; tool; transgenic; tumor; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",Regulation of Epidermal Differentiation on Engineered Polymer Substrates,,56182,ZRG1,Special Emphasis Panel,X1,2,7850,
7749014,F32,AR,5,,12/01/2009,11/30/2010,,5F32AR056182-02,,NIAMS:41796;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,,UNITED KINGDOM,,,,UK,,,CANCER RESEARCH UK CAMBRIDGE RES INST,"CONNELLY, JOHN THOMAS;",9178913;,5F32AR056182,12/01/2008,11/30/2011,"1,2-Ethanediol; 2-Hydroxyethanol; 2-hydroxyethyl methacrylate; 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester; 4-Hydroxy-Tamoxifen; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; 9-diethylamino-5H-benzo(a)phenoxazine-5-one; Adhesions; Adhesives; Aminoacetic Acid; Area; Arg-Gly-Asp; Arginine; Arginine, L-Isomer; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain; Aspartic Acid; Assay; BUdR; Behavior; Benzoic acid, 3,4,5-trimethoxy-, 4-(acetyloxy)-6,10-dimethyl-3-(1-methylethyl)-11-oxabicyclo(8.1.0)undec-6-en-2-yl ester; Bioassay; Biocompatible Materials; Biologic Assays; Biological Assay; Biomaterials; Biomedical Engineering; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CD34; CD34 gene; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Caliber; Catenin, Beta-1; Cell Communication and Signaling; Cell Density; Cell Function; Cell Growth in Number; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cell-Extracellular Matrix; CellLine; Cells; Cellular Function; Cellular Morphology; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular biology; Centrifugation; Cold-Insoluble Globulins; Complex; Cues; Cultured Cells; Density, Cell; Development; Diameter; Dihydroxyethanes; Dose; ECM; Engineering; Engineerings; Environment; Epidermis; Ethanediols; Ethylene Glycols; Exposure to; Extracellular Matrix; Extracellular Matrix, Integrins; FN1; FNZ; Fibronectin 1; Fibronectins; Fractionation, Centrifugation; Glycine; Goals; HPCA1; Hair Follicle; Hair follicle structure; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Vitro; Integrins; Intracellular Communication and Signaling; Island; K7, keratin; Ker10 protein; Keratin; L-Arginine; L-Aspartic Acid; LETS Proteins; Large External Transformation-Sensitive Protein; Ligands; Malignant Cell; Malignant Skin Neoplasm; Malignant Tumor of the Skin; Mammals, Mice; Measures; Mediating; Melanoma and Non-Melanoma Skin Cancer; Mice; Mice, Transgenic; Monoethylene Glycol; Morphology; Mother Cells; Mouse Strains; Murine; Mus; Oligo; Oligonucleotides; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; PRO2286; Pathology; Pathway interactions; Pattern; Play; Polymer Chemistry; Polymers; Position; Positioning Attribute; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RGD; RGD (peptide); RGD (sequence); RGD Cell Adhesion Domain; RGD Domain; RGD Motif; RGD Tripeptide Sequence; RGD tripeptide; Receptor Protein; Regulation; Research; Research Institute; Research Proposals; Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Stem cells; Subcellular Process; Surface; System; System, LOINC Axis 4; Therapeutic Agents; Transgenes; Transgenic Mice; Transgenic Organisms; Uridine, 5-bromo-2'-deoxy-; Wild Type Mouse; Work; alpha 2-Surface Binding Glycoprotein; arginyl-glycyl-aspartic acid; base; beta catenin; bioengineering; bioengineering/biomedical engineering; biological signal transduction; c myc; c-myc Genes; cancer cell; cell biology; cell morphology; cultured cell line; density; epiligrin; ethylene glycol; experiment; experimental research; experimental study; gene product; glycol methacrylate; hydroxyethyl methacrylate; improved; insight; involucrin; kalinin; keratin 10; keratin 7; keratin-7, K7; keratinocyte; keratinocyte differentiation; laminin-5; light microscopy; loricrin; migration; nicein; nile red; notch; notch protein; notch receptors; novel; para-hydroxytamoxifen; pathway; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; polymerization; receptor; research study; resistant; response; self-renewal; social role; stem cell biology; stem cell differentiation; synthetic peptide; tamoxifen metabolite B; tool; transgenic; tumor; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",Regulation of Epidermal Differentiation on Engineered Polymer Substrates,,56182,ZRG1,Special Emphasis Panel,,2,41796,
7743840,F32,CA,5,,12/01/2009,11/30/2010,,5F32CA126247-03,,NCI:53810;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,059709394,US,MA,02115,"IMMUNE DISEASE INSTITUTE, INC.","PIPKIN, MATTHEW EUGENE;",8620155;,5F32CA126247,12/01/2007,11/30/2010,"0-11 years old; Ablation; Alleles; Allelomorphs; Biochemical; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CHIP assay; CTL; Cancers; Cell Body; Cell Culture Techniques; Cell Differentiation; Cell Differentiation process; Cell-Mediated Lympholytic Cells; Cells; Cells, CD4; ChIP (chromatin immunoprecipitation); Child; Child Youth; Children (0-21); Chromatin; Chromatin Structure; Cytokine Gene; Cytolytic T-Cell; Cytoplasmic Granules; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; DNA Endonuclease; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; DNA-Dependent RNA Polymerase II; DNase; DNase I; Deoxyribonuclease I; Disease; Disorder; Distal; Doctor of Philosophy; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; FP593; Family; Functional RNA; Gene Products, RNA; Gene Transcription; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genomics; Goals; Health; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hereditary; Human; Human, Child; Human, General; IRES; ITX; Immune; Immune response; Immunologically Directed Therapy; Immunotherapy; Individual; Inducer Cells; Infant; Infection; Inflammatory; Inherited; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; K lymphocyte; Killings; Knowledge; Laboratories; Link; Locus Control Region; Lymphocyte; Lymphocytic; Lytotoxicity; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mechanics; Mediating; Messenger RNA; Methods; Mice; Mice, Mutant Strains; Mice, Transgenic; Moab, Clinical Treatment; Modeling; Modification; Molecular; Monoclonal Antibodies; Murine; Mus; Mutant Strains Mice; Mutation; NK Cells; Natural Killer Cells; Non-Coding; Non-Coding RNA; Pancreatic DNase; Pathway interactions; Patients; Ph.D.; PhD; Phosphorylation; Physiologic; Physiological; Pol II; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; RNA; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA, Messenger; RNA, Non-Polyadenylated; Recruitment Activity; Regulatory Element; RegulatoryElement; Reporter; Ribonucleic Acid; Ribosome Entry Site; Role; Site; T-Cells, Helper-Inducer; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Thymonuclease; Training; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenes; Transgenic Mice; Vaccine Design; Viral Diseases; Virus Diseases; base; cell body (neuron); children; chromatin immunoprecipitation; chromatin remodeling; cytolysin; cytolysin, mouse; cytotoxic; cytotoxicity; disease/disorder; drFP583; ds red protein; dsFP593; familial hemophagocytic lymphohistiocytosis; genome mutation; granule; helper T cell; histone modification; host response; human disease; immune therapy; immunoresponse; lymph cell; lymphocyte pore-forming protein; lymphocyte pore-forming protein, mouse; mRNA; malignancy; mouse mutant; mouse perforin; neoplasm/cancer; neural cell body; neuronal cell body; pathway; perforin; perforin protein, mouse; perforin, mouse; prevent; preventing; recruit; red fluorescent protein; skills; social role; soma; transgene expression; tumor; viral infection; virus infection; youngster",Mechanics of LCR action on perforin to establish cytotoxicity in NK cells and CTL,,126247,ZRG1,Special Emphasis Panel,,3,53810,
7748002,F32,CA,5,,12/01/2009,11/30/2010,,5F32CA128265-02,,NCI:52154;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"SHEN, RHINE ;",8712215;,5F32CA128265,12/01/2008,11/30/2011,"AKT; Active Follow-up; Akt protein; Anchorage-Independent Growth; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Biochemical; Biochemical Pathway; Breast; Breast Cancer Cell; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer cell line; Cancer of Breast; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Signaling; Chemotherapeutic Agents, Neoplastic Disease; Development; EC 2.7; Epithelial Cells; Event; Exhibits; Experimental Models; Experimental Models, Other; Familial Breast Carcinoma; Familial Cancer of the Breast; Hereditary Breast Cancer; Hereditary Breast Carcinoma; High Throughput Assay; Human; Human Breast Cancer Cell; Human, General; Immunodeficient Mouse; Intracellular Communication and Signaling; Kinases; Libraries; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Metabolic Networks; Modeling; Models, Experimental; Modification; Molecular; Oncogenes; PKB protein; Pathway interactions; Patients; Peptide Library; Phenotype; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Kinase B; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; Quelling; RAC-PK protein; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Role; Sampling; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Training; Transforming Genes; Transphosphorylases; Tumor-Specific Treatment Agents; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Work; anticancer agent; anticancer drug; anticancer research; anticancer therapy; biological signal transduction; c-akt protein; cancer genome; cancer research; cancer therapy; cell transformation; drug development; follow-up; functional genomics; gene product; high throughput screening; inhibitor; inhibitor/antagonist; malignant breast neoplasm; mammary; novel; overexpression; pathway; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; screening; screenings; social role; therapeutic target; transformed cells; tumor; tumorigenic; ubiquination; ubiquitin conjugation",The Function of IKKeplison in Breast Cancer,,128265,ZRG1,Special Emphasis Panel,,2,52154,
7743733,F32,CA,5,,12/01/2009,11/30/2010,,5F32CA130312-02,,NCI:52154;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"WILSON, BORIS G.;",8830866;,5F32CA130312,12/01/2008,11/30/2011,"0-11 years old; ATP phosphohydrolase; ATPase; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Autoregulation; BAF155; BAF155 Gene; BAF47; BAF47 Gene; Binding; Binding (Molecular Function); Blastocyst; Blastocyst structure; Blastosphere; Body Tissues; Breast; CRACC1 Gene; Cancer stem cell; Cancers; Cells; Child; Child Youth; Children (0-21); Chromatin Remodeling Complex; Chromatin Remodeling Complex BAF155 Subunit Gene; Chromatin Remodeling Factor; Complex; Crossmatching, Tissue; Data; Defect; Development; Drosophila SWI/SNF; ES cell; Embryo; Embryo, Preimplantation; Embryonic; Equilibrium; Familiar Malignant Neoplasm; Gastrointestinal Tract, Pancreas; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Generalized Growth; Genetic Algorithm; Genetic Alteration; Genetic Change; Genetic Programming; Genetic Transcription; Genetic defect; Genital System, Male, Prostate; Goals; Growth; Hereditary Cancer; Hereditary Malignant Neoplasm; Histocompatibility Testing; Homeostasis; Human Prostate; Human Prostate Gland; Human, Child; INI1; INI1 Gene; Lead; Lung; Malignant Neoplasms; Malignant Tumor; Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 155 Gene; Mammals, Mice; Mice; Molecular Interaction; Mother Cells; Murine; Mus; Mutation; Nucleosomes; Oncogenesis; Oncogenic; Pancreas; Pancreatic; Pathway interactions; Pb element; Physiological Homeostasis; Polycomb; Predisposition; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Prostate; Prostate Gland; Prostatic Gland; Proteins; RDT; RNA Expression; Reserve Stem Cell; Respiratory System, Lung; Role; Rsc8 Gene; SMARCB1; SMARCB1 gene; SMARCC1; SMARCC1 gene; SNF5; SNF5 Gene; SNF5L1; SNF5L1 Gene; SRG3 Gene; SWI/SNF Complex 155 kDa Subunit Gene; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Gene; SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 1 Gene; SWI3 Gene; Staging; Stem cells; Susceptibility; Syndrome; Tissue Crossmatchings; Tissue Growth; Tissue Typing; Tissues; Transcription; Transcription, Genetic; Tumor Cell; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; balance; balance function; base; blastocyst; blastula; children; dSWI/SNF; embryonic stem cell; experiment; experimental research; experimental study; familial cancer; gene product; genome mutation; hSNF5/INI1 Gene; heavy metal Pb; heavy metal lead; histocompatibility typing; insight; malignancy; member; mouse model; neoplasm/cancer; neoplastic cell; ontogeny; pathway; pluripotency; prevent; preventing; programs; pulmonary; research study; self-renewal; social role; stem; stem cell of embryonic origin; tumor; tumor suppressor; tumorigenesis; youngster",The Swi/Snf tumor suppressor in stem cell self-renewal and pluripotency,,130312,ZRG1,Special Emphasis Panel,,2,52154,
7764651,F32,CA,5,,01/06/2010,12/31/2010,,5F32CA132350-02,,NCI:52154;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,53,020520466,US,CA,92037,BURNHAM INSTITUTE FOR MEDICAL RESEARCH,"MILETIC SEDY, ANA ;",8971223;,5F32CA132350,01/06/2009,12/31/2011,"1L-myo-inositol-1-phosphatase; 1L-myo-inositol-1-phosphate phosphohydrolase; ATGN; Adoptive Transfer; Animals; Antigens; Assay; Autoantigens; Autologous Antigens; B blood cells; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; BZS; Bioassay; Biologic Assays; Biological Assay; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Causality; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cell surface; Cells; Characteristics; Clonality; Development; Disease; Disorder; Etiology; Frequencies (time pattern); Frequency; Gene Chips; Gene Expression Chip; Genes; Germinoblastoma; Goals; Human; Human, General; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; Intracellular Communication and Signaling; Life; Lilium; Lily; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lymphoma, Non-Hodgkin's; Lymphoma, Nonhodgkins; Lymphomagenesis; MHAM; MMAC1; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Molecular; Murine; Mus; Nature; Neoplasm Metastasis; Non-Hodgkin's Lymphoma; Organ; PTEN; PTEN gene; PTEN1; Pathogenesis; Pathogenicity; Penetrance; Phenotype; Phosphatase and Tensin Homolog; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Reticulolymphosarcoma; Sarcoma, Germinoblastic; Secondary Neoplasm; Secondary Tumor; Self-Antigens; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; Testing; Therapeutic; Tumor Cell Migration; biological signal transduction; cancer metastasis; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gene product; immunogen; improved; in vivo; inositol monophosphatase; inositol monophosphate phosphatase impA; inositol phosphatase; inositol-1-phosphate phosphohydrolase; myo-inositol monophosphatase; myo-inositol-1 (or 4)-monophosphatase; myo-inositol-1-phosphatase; new therapeutics; next generation therapeutics; non-Hodgkin's lymphoma; non-Hodgkins disease; non-Hodgkins lymphoma; novel; novel therapeutics; reconstitute; reconstitution; success",Coordinate Suppression of B Cell Lymphoma by PTEN and SHIP,,132350,ZRG1,Special Emphasis Panel,,2,52154,
7779940,F32,CA,5,,01/28/2010,01/27/2011,PA-07-107,5F32CA138084-02,,NCI:47606;,2010,NATIONAL CANCER INSTITUTE,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"SCHNERMANN, MARTIN JOHN;",9460748;,5F32CA138084,01/28/2009,01/27/2012,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 22-Oxovincaleukoblastine; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; Adriamycine; Amines; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Attention; Binding; Binding (Molecular Function); Biological; Biological Factors; Biological Function; Biological Process; Boronic Acids; Cancer Drug; Cancers; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Complex; Cyclization; DOX; Development; Dimerization; Doxorubicin; Doxorubicina; Drug Resistance, Multiple; Drug Resistant, Multiple; Evaluation; Factor, Biologic; Generations; Glycoproteins; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; In Vitro; Lead; Leurocristine; Malignant Neoplasms; Malignant Tumor; Method LOINC Axis 6; Methodology; Methods; Modification; Molecular Interaction; Multi-Drug Resistance; Multidrug Resistance; Natural Products; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nucleus; Pb element; Play; Process; Property; Property, LOINC Axis 2; Protein Dimerization; Reaction; Research Design; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Source; Study Type; System; System, LOINC Axis 4; Transmission; Tumor-Specific Treatment Agents; VCR; Vincaleukoblastine, 22-oxo-; Vincristine; Vincrystine; Work; analog; anticancer agent; anticancer drug; chemical synthesis; cultured cell line; cytotoxic; drug development; gardneramine; heavy metal Pb; heavy metal lead; improved; in vivo; interest; malignancy; monomer; multi-drug resistant; multidrug resistant; neoplasm/cancer; novel; overexpression; oxindole; oxovincaleukoblastine; public health relevance; social role; study design; tool; transmission process",Enatioselective Synthesis of Gardneria Oxindole Natural Products,,138084,ZRG1,Special Emphasis Panel,,2,47606,
7917383,F32,CA,5,,01/28/2010,01/27/2011,,5F32CA138103-02,,NCI:47606;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"GARSKE, ADAM LIVINGSTON;",9397665;,5F32CA138103,01/28/2009,01/27/2012,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 1-Phosphatidylinositol 3-Kinase; 5'-AMP-activated protein kinase; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Alleles; Allelomorphs; Amino Acids; Apoptosis; Apoptosis Pathway; Apoptotic; Autophagocytosis; Cancer Treatment; Cancers; Catabolism; Cell Components; Cell Cycle Arrest; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell Structure; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Stress; Cellular Structures; Chemicals; Development; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7; Enzymes; Family; GFAC; Genetics-Mutagenesis; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Isoforms; Kinases; Lead; Link; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic stress; Molecular Biology, Mutagenesis; Mutagenesis; Mutagenesis, Site-Directed; Mutate; Nature; Nutrient; Organic Synthesis; Outcome; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Pb element; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphotransferases; Process; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Kinase Inhibitors; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; PtdIns; PtdIns 3-Kinase; Reagent; Regulation; Reporting; Research; Role; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specificity; Starvation; Subcellular Process; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Threonine Kinase; Transphosphorylases; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Variant; Variation; Withdrawal; aminoacid; anticancer therapy; autophagy; base; cancer cell; cancer therapy; chemical genetics; chemotherapy; diabetes; disease/disorder; gene product; genetic inhibitor; glucose uptake; heavy metal Pb; heavy metal lead; hydroxymethylglutaryl-CoA-reductase kinase; inhibitor; inhibitor/antagonist; insight; kinase inhibitor; malignancy; mimetics; necrocytosis; neoplasm/cancer; pathway; prevent; preventing; programs; protein kinase inhibitor; protein kinase modulator; public health relevance; response; sensor; small molecule; social role; therapeutic target; tool",Probing Autophagy Regulation in Cancer with Chemical Approaches,,138103,ZRG1,Special Emphasis Panel,,2,47606,
7765607,F32,DA,5,,02/01/2010,01/31/2011,,5F32DA023354-03,,NIDA:52154;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"CASON, ANGIE ;",8731436;,5F32DA023354,02/01/2008,01/31/2011,"1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Behavior; Cocaine; Common Rat Strains; Cues; Data; Dopamine; Drugs; Estrogenic Agents; Estrogenic Compounds; Estrogens; Female; Gustation; Hand; Hydroxytyramine; Individual Differences; Intake; Literature; Lithium Chloride; Lithium chloride (LiCl); Mammals, Rats; Medication; Pharmaceutic Preparations; Pharmaceutical Preparations; Rat; Rattus; Resistance; Rewards; Saccharin; Saline; Saline Solution; Self Administration; Self-Administered; Sex Characteristics; Sex Differences; Solutions; Stimulus; Taste; Taste Perception; Testing; Therapeutic Estrogen; abused drugs; addiction; drug of abuse; drug reward; drug/agent; drugs abused; drugs of abuse; gender difference; male; preference; protective effect; resistant; response; sex; sexual dimorphism (noncellular)","Drugs of Abuse, Gender Differences, and Protection by Sweets",,23354,NIDA,Neuropharmacology Research Subcommittee,,3,52154,
7766991,F32,DA,5,,02/01/2010,01/31/2011,,5F32DA024524-02,,NIDA:52154;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"HENRY, BROOK ;",8939446;,5F32DA024524,02/01/2009,01/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Addiction, Drug; Affective Disorders; Affective Psychosis, Bipolar; Ambulatory Monitoring; Amphetamines; Attenuated; Au element; Basal Ganglia; Basal Nuclei; Behavior; Behavioral; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bipolar Disorder; Brain region; Cardiac; Causality; Chemical Dependence; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clinical assessments; Cognition; Cognitive; Crystal Meth; DAT; DAT dopamine transporter; Data; Deoxyephedrine; Dependence, Drug; Dependence, Substance; Desoxyephedrine; Development; Diagnosis; Disease; Disorder; Dopamine; Drug Addiction; Drug Dependency; Drug abuse; Dysfunction; Elements; Environment; Etiology; Exhibits; FLR; Failure (biologic function); Functional disorder; Funding; Furniture; Genetic; Goals; Gold; History; Human; Human, General; Hydroxytyramine; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Impulsivity; Individual; Inpatients; Knock-out; Knockout; Locomotor Activity; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manias; Manic; Manic State; Measures; Mediating; Mental disorders; Mental health disorders; Methamphetamine; Methamphetamine dependence; Methylamphetamine; Modeling; Monitor; Monitoring, Ambulatory; Mood Disorders; Moods; Motor; Motor Activity; N-Methylamphetamine; NIH RFA; Nervous; Neurobiology; Out-patients; Outpatient Monitoring; Outpatients; Participant; Pathology; Pattern; Pharmacological Treatment; Physiopathology; Population; Prefrontal Cortex; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychosis, Manic-Depressive; Recording of previous events; Regulation; Reporting; Request for Applications; Respiration; Rodent; Rodent Model; Rodentia; Rodentias; Salaries; Severities; Substance Addiction; Substance abuse problem; Symptoms; System; System, LOINC Axis 4; Tactile; Testing; Translational Research; Translational Research Enterprise; Translational Science; Treatment outcome; United States; Unspecified Mental Disorder; Wages; Work; abuse of drugs; abuse of substances; abuses drugs; base; bipolar affective disorder; clinical investigation; cost; design; designing; disability; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; dopamine transporter; dopamine transporter proteins; experiment; experimental research; experimental study; failure; improved; innovate; innovation; innovative; manic depressive disorder; manic depressive illness; mental illness; monitoring device; neural; neurobiological; neuropsychiatric; neuropsychiatry; neurotoxic; novel; pathophysiology; psychological disorder; public health relevance; relating to nervous system; research study; respiratory mechanism; response; substance abuse; translation research enterprise; ward",Inhibitory Deficits in Bipolar Disorder and Methamphetamine Dependence,,24524,ZRG1,Special Emphasis Panel,,2,52154,
7759191,F32,DA,5,,01/16/2010,01/15/2011,PA-07-107,5F32DA024537-03,,NIDA:60282;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HOUSTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"RATLIFF, ERIC ;",8932067;,5F32DA024537,01/16/2008,01/15/2011,"21+ years old; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adult; Affect; African American; Afro American; Afroamerican; Behavior; Behavioral; Black Populations; Black or African American; Categories; Characteristics; Coitus; Complex; Conflict; Conflict (Psychology); Contracting Opportunities; Contracts; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Collection; Disease Frequency Surveys; Drug usage; Drug user; Drugs; Economically Deprived; Economically Deprived Population; Elements; Environment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Equation; Family member; Fellowship; Foundations; Friends; Future; Goals; Government; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Health; Human Immunodeficiency Viruses; Human Sexual Intercourse; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Individual; Intervention; Intervention Strategies; Investigation; Investigators; Knowledge; LAV-HTLV-III; Lead; Learning; Link; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Marriage; Measures; Medication; Methods; Minority; Modeling; Neighborhoods; Outcome; Pathway interactions; Pb element; Personal Behavior; Personal Conduct; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Policies; Population; Position; Positioning Attribute; Process; Property; Property, LOINC Axis 2; Qualitative Methods; R01 Mechanism; R01 Program; RPG; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Researchers; Risk; Risk Behaviors; Risky Behavior; Role; Sampling; Sexual Intercourse; Sexual Partners; Social Environment; Social Identification; Social Identity; Social Interaction; Social status; Social support; Solid; Source; Stress; Stress Disorders; Stress Disorders, Traumatic; Structure; Study Type; Survey Instrument; Surveys; Testing; Texas; Time; Training Programs; Transmission; Traumatic Stress Disorders; Trust; Unemployment; Violence; Virus-HIV; Work; adult human (21+); at risk behavior; base; black American; career; drug use; drug/agent; expectation; experience; heavy metal Pb; heavy metal lead; high risk behavior; inner city; innovate; innovation; innovative; interventional strategy; jobless; joblessness; novel; out of work; pathway; phase 1 study; psychologic; psychological; psychosocial; sex; sex partner; sexually active; skills; social; social climate; social context; social integration; social role; social support network; socioenvironment; study design; transmission process; unemployed; violent; violent behavior",Close Relationships and HIV Risk among Inner-city Drug Users,,24537,NIDA,Neuropharmacology Research Subcommittee,,3,60282,
7751272,F32,DA,5,,01/01/2010,12/31/2010,PA-07-107,5F32DA026240-02,,NIDA:52154;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,COLUMBUS,UNITED STATES,PHARMACOLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"AMICI, STEPHANIE ANN;",9410505;,5F32DA026240,01/01/2009,12/31/2011,"12-20 years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; ATF; Addiction, Drug; Addictive Behavior; Adhesion Molecule; Adolescence; Ammon Horn; Animal Model; Animal Models and Related Studies; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Axon Terminals; Binding; Binding (Molecular Function); Binding Sites; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; Cell Adhesion Molecules; Cell surface; Cells; Chemical Dependence; Chronic; Co-culture; Coagulation Factor IV; Cocultivation; Coculture; Coculture Techniques; Combining Site; Common Rat Strains; Complex; Cornu Ammonis; Cot Death; Crib Death; Data; Dendrites; Dependence, Drug; Dependence, Nicotine; Development; Disease; Disorder; Dopamine; Drug Addiction; Drug Dependency; Drug abuse; Dysfunction; Encephalon; Encephalons; Factor IV; Family; Figs; Figs - dietary; Functional disorder; GWAS; Genes; Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Hydroxytyramine; Kanner's Syndrome; Laboratories; Lead; Length; Link; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Molecular; Molecular Interaction; Monitor; Mortality; Mortality Vital Statistics; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nucleus Accumbens; Pathway interactions; Pb element; Physiopathology; Polymorphism, Single Base; Predisposition gene; Presynaptic Terminals; Process; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reactive Site; Recombinants; Reporting; Research; Rewards; SIDS; SNP; SNPs; Schizophrenia; Schizophrenic Disorders; Single Nucleotide Polymorphism; Spinal Column; Spine; Structure of ciliary ganglion; Sudden Infant Death; Sudden Unexpected Death of Infant; Sudden Unexpected Infant Death; Sudden infant death syndrome; Susceptibility Gene; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Testing; Tobacco Cessation; Tobacco Consumption; Tobacco Use Cessation; Tobacco use; Up-Regulation; Up-Regulation (Physiology); Upregulation; Ventral Tegmental Area; Vertebral column; abuse of drugs; abused drugs; abuses drugs; activating transcription factor; addiction; adolescence (12-20); backbone; base; cell adhesion protein; cholinergic synapse; ciliary ganglion; critical period; dementia praecox; density; disease/disorder; drug of abuse; drugs abused; drugs of abuse; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; hippocampal; in vivo Model; insight; model organism; multisubstance abuse; mutant; neuroligin 1; neuronal; nicotine addiction; novel; pathophysiology; pathway; polysubstance abuse; postsynaptic; predisposing gene; presynaptic; public health relevance; receptor expression; receptor function; schizophrenic; synapse formation; synapse function; synaptic function; synaptogenesis; teenage; ventral tegmentum; whole genome association studies; whole genome association study",Nicotine Dependence and Modulation of Synapse Maturation,,26240,ZRG1,Special Emphasis Panel,,2,52154,
7758749,F32,DA,5,,01/01/2010,12/31/2010,,5F32DA026254-02,,NIDA:52154;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"REISSNER, KATHRYN JOANNA;",9441282;,5F32DA026254,01/01/2009,12/31/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acetylcysteine; Acetylin; Actin Filaments; Actins; Acute; Address; Affect; Airbron; Allen & Hanburys Brand of Acetylcysteine; Animal Model; Animal Models and Related Studies; Architecture; Autoregulation; Behavior; Behavioral; Binding; Binding (Molecular Function); Bristol-Myers Squibb Brand of Acetylcysteine; Bristol-Myers Squibb Brand of Acetylcysteine Sodium Salt; Broncholysin; Brunac; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Chronic; Cocaine; Complex; Cytoskeletal Proteins; Data; Dendritic Spines; Development; Diacetylmorphine; Diamorphine; Drug Therapy; Drug usage; Drugs; Engineering / Architecture; F-Actin; Fabrol; Family; Filamentous Actin; Fluatox; Fluimucetin; Fluimucil; Fluprowit; G Actin; Globular Actin; Glutamates; Goals; Heroin; Homeostasis; Injection of therapeutic agent; Injections; Inpharzam Brand of Acetylcysteine; Intracellular Communication and Signaling; L-Alpha-acetamido-beta-mercaptopropionic Acid; L-Glutamate; Lead; Mediating; Medication; Mercapturic Acid; Microfilaments; Modeling; Molecular; Molecular Interaction; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphology; Muco Sanigen; Mucocedyl; Mucolator; Mucolyticum; Mucomyst; Mucosolvin; Mucret; Myofilaments; N-Acetyl Cysteine; N-Acetyl-L-cysteine; N-Acetylcysteine; N-WASP protein; N-acetyl-3-mercaptoalanine; NAC; NAC Zambon; Neo-Fluimucil; Neuronal Plasticity; Nucleus Accumbens; Optipect Hustengetr??nk; Parvolex; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiological Homeostasis; Process; Produpharm Lappe Brand of Acetylcysteine; Protein Dynamics; Protein Family; Proteins; Regulation; Relapse; Reporting; Research; Respaire; Roberts Brand of Acetylcysteine; Self Administration; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Column; Spine; Structure; Thiemann Brand of Acetylcysteine; Tixair; UPSA Brand of Acetylcysteine; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebral column; WAS gene product; WASP protein; Withdrawal; Zambon Brand of Acetylcysteine; Zyma Brand of Acetylcysteine; addiction; backbone; biological signal transduction; cocaine exposure; cocaine use; d-Numb; dendrite spine; density; drug use; drug/agent; experience; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; member; model organism; neural plasticity; neuroplasticity; numb protein; polymerization; postsynaptic; prevent; preventing; protein complex; research study; response",Cytoskeletal Mechanisms of Cocaine-Induced Neuroplasticity,,26254,ZRG1,Special Emphasis Panel,,2,52154,
7758820,F32,DA,5,,01/01/2010,12/31/2010,PA-07-107,5F32DA026265-02,,NIDA:50474;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SEATTLE,UNITED STATES,PHARMACOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"FURAY, AMY REBECCA;",9177847;,5F32DA026265,01/01/2009,12/31/2010,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT(1B) Receptor; 5-HT(1Dbeta) Receptor; 5-HT1B Receptor; 5-HT1Dbeta Receptor; 5-Hydroxytryptamine; 5HT; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Anhedonia; Animals; Back; Behavior; Behavioral; Behavioral Paradigm; Brain region; Chronic; Chronic stress; Cocaine; DA Neuron; Data; Depression; Dopamine neuron; Dopaminergic Cell; Dorsum; Drug abuse; Drugs; Elements; Enteramine; Exposure to; Gene Transfer; Genetics, in situ Hybridization; Health; Hippophaine; In Situ Hybridization; Link; Literature; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mental Depression; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Modeling; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleus Accumbens; Organism; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Property; Property, LOINC Axis 2; RNA, Messenger; RNA, Small Interfering; Receptor Protein; Receptor, 5-Hydroxytryptamine 1B; Receptor, Serotonin Type 1Dbeta; Receptor, Serotonin, 5-HT1B; Rewards; Ribonucleic acids, transfer; Role; Serotonin; Serotonin 1B Receptor; Serotonin 1D Beta Receptor; Serotonin 1Dbeta Receptor; Small Interfering RNA; Stimulus; Stress; Synapses; Synaptic; Techniques; Training; Transfer RNA; Triplet Codon-Amino Acid Adaptor; Ventral Tegmental Area; Viral; abuse of drugs; abuses drugs; dopaminergic neuron; drug reward; drug/agent; effective therapy; experience; experiment; experimental research; experimental study; hedonic; in situ Hybridization Staining Method; living system; mRNA; mRNA Expression; neuronal; overexpression; preference; prevent; preventing; psychostimulant; receptor; receptor expression; research study; response; siRNA; social; social model; social role; social stress; stressor; tRNA; transfer of a gene; ventral tegmentum",The role of  5-HT 1Beta receptors in regulating hedonic state and reward,,26265,ZRG1,Special Emphasis Panel,,2,50474,
7741216,F32,DK,5,,12/01/2009,11/30/2010,,5F32DK079499-02,,NIDDK:52154;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,PHYSIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LEE, FLORENCE YING;",8834035;,5F32DK079499,12/01/2008,11/30/2010,"21+ years old; AD4BP protein; Ad4-binding protein; Adult; Alleles; Allelomorphs; American; Appetite; Architecture; Arcuate Nucleus; Assay; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Body Weight; Brain; Brain region; Cardiovascular Diseases; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Co-Immunoprecipitations; Complement; Complement Proteins; Custom; Desire for food; Development; Diabetes Mellitus; Diet; Dorsal; Drosophila; Drosophila genus; Encephalon; Encephalons; Endocrine Physiology; Engineering / Architecture; FTZF1 protein; Family member; Fats; Fatty acid glycerol esters; Fruit Fly, Drosophila; Fushi tarazu factor homolog 1; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profile; Gene Expression Profiling; Gene Targeting; Gene Transcription; GeneHomolog; Generations; Genes; Genes, Reporter; Genetic Transcription; Genetics, in situ Hybridization; Goals; Homeostasis; Homolog; Homologous Gene; Homologue; HuB219; Human, Adult; Hypothalamic structure; Hypothalamus; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Luciferase; In Situ Hybridization; Infundibular Nucleus; Knockout Mice; LEP-R; LEPR; LEPR Protein; Lead; Luciferases; Mammals, Mice; Medial; Metabolic; Metabolic Control; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Mechanisms of Action; Murine; Mus; NR5A1 protein; Neonatal; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Nucleus; Null Mouse; OB Receptor; OB-R; Obesity; Over weight; Overweight; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathway interactions; Pattern; Pb element; Physiologic; Physiological; Physiological Homeostasis; Play; Population; Printing; Profilings, Gene Expression; Proteins; RNA Expression; Reporter; Reporter Genes; Research Proposals; Role; SF 1; SF-1 transcription factor; SF1; Saccharose; Science of Statistics; Statistics; Structure of nucleus infundibularis hypothalami; Structure of paraventricular nucleus; Structure of ventromedial hypothalamic nucleus; Sucrose; Targetings, Gene; Tea; Therapeutic Intervention; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription, Genetic; Two Hybrid; Ventromedial Hypothalamic Nucleus; Wing; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adiposity; adrenal 4 binding protein; adult human (21+); alpha-D-Glucopyranoside, beta-D-fructofuranosyl; brain control; cDNA Library; cancer type; cardiovascular disorder; cofactor; combat; corpulence; corpulency; corpulentia; cultured cell line; diabetes; diabetes risk; drug development; energy balance; experiment; experimental research; experimental study; fruit fly; gene expression signature; gene product; ghrelin receptor; heavy metal Pb; heavy metal lead; hypothalamic; in situ Hybridization Staining Method; intervention therapy; leptin receptor; leptin-binding protein; mind control; molecular marker; nestin; nestin protein; neuronal; novel; novel marker; nuclear receptor 5A1 protein; obese; obese people; obese person; obese population; obesity treatment; paraventricular nucleus; pathway; research study; social role; statistics; steroid hormone receptor Ad4BP; steroidogenic factor 1; transcription factor sf1; transcriptome; ventromedial hypothalamic nucleus; yeast two hybrid system",Neuroendocrine Pathways Governing Energy Homeostasis,,79499,ZRG1,Special Emphasis Panel,,2,52154,
7749543,F32,DK,5,,02/01/2010,01/31/2011,,5F32DK079649-03,,NIDDK:52154;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MILWAUKEE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"KOHLER, SARAH E;",8841031;,5F32DK079649,02/01/2008,01/31/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; ATRA; Activation, Gene; Address; Affect; Albumins; All-trans retinoic acid; Alpha-1-Fetoprotein; Alpha-Fetoglobulin; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cancers; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Chromatin Structure; Combining Site; DNA; DNA Binding Domain; DNA Endonuclease; DNase; DNase I; Data; Defect; Deoxyribonuclease I; Deoxyribonucleases; Deoxyribonucleic Acid; Development; Embryo Development; Embryogenesis; Embryonic Development; Endoderm; Enhancers; Fetuins; Foregut; Gene Action Regulation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Histones; In Vitro; Intermediary Metabolism; Lead; Liver; Liver Cells; METBL; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic Processes; Metabolism; Micrococcal Nuclease; Mixed Embryonal Carcinoma and Teratoma; Modeling; Molecular Interaction; Mutate; Mutation; Nucleases, DNA; Nucleosomes; Organ; Organogenesis; Pancreatic DNase; Pb element; Physiologic; Physiological; Play; Prealbumin; Primitive foregut structure; Proalbumin; Process; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Motifs, DNA-Binding; RNA Expression; Reactive Site; Regulation; Research; Retinoic Acid; Role; Series; Staphylococcal Nuclease; Structure; TNase; Teratocarcinoma; Testing; Thermonuclease; Thermostable Nuclease; Thymonuclease; Trans Vitamin A Acid; Transcription; Transcription, Genetic; Transthyretin; Tretinoin; Tretinoinum; Up-Regulation; Up-Regulation (Physiology); Upregulation; Visceral; Vitamin A Acid; all-trans-Retinoic Acid; all-trans-Vitamin A acid; alpha-Fetoproteins; base; body system, hepatic; cell type; chromatin immunoprecipitation; chromatin remodeling; cultured cell line; experiment; experimental research; experimental study; genetic promoter element; genome mutation; heavy metal Pb; heavy metal lead; hepatocyte nuclear factor; in vivo; interest; knock-down; malignancy; neoplasm/cancer; organ system, hepatic; precursor cell; research study; shRNA; short hairpin RNA; small hairpin RNA; social role; trans-Retinoic Acid; transcription factor",HNF3-mediated chromatin remodeling: A role in liver gene regulation,,79649,ZRG1,Special Emphasis Panel,,3,52154,
7752837,F32,DK,5,,02/01/2010,01/31/2011,,5F32DK082028-03,,NIDDK:52154;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,NUTRITION,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"CHANDLER-LANEY, PAULA CATHERINE;",8969711;,5F32DK082028,02/01/2008,01/31/2011,"0-11 years old; 8 year old; Adverse effects; African; African American; Afro American; Afroamerican; American; Area; Attenuated; Authorization; Authorization documentation; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Black Populations; Black or African American; Body Composition; Body fat; Boxing; Chemotherapy-Hormones/Steroids; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical Research; Clinical Study; Communities; Comorbidity; Diabetes Mellitus, Gestational; Diabetes, Gestational; Diabetes, Pregnancy-Induced; Diabetic intrauterine environment; Diet; Dietary intake; Differentiation Factor, B-Cell; Dyslipidemias; Eating; Endocrine Gland Secretion; Enrollment; Ensure; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Exhibits; Exposure to; Family; Fasting; Fats; Fatty acid glycerol esters; Female of child bearing age; Female of childbearing age; Food Intake; GLP-1; Genotype; Gestation; Gestational Diabetes; HDL Cholesterol; HPGF; Health; Hepatocyte-Stimulating Factor; High Density Lipoprotein Cholesterol; High Prevalence; Home; Home environment; Hormones; Hour; Human, Child; Humulin R; Hybridoma Growth Factor; Hyperglyceridemia; Hypertriglyceridemia; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Inpatients; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intake; Interleukin 6 (Interferon, Beta 2); Interleukin-6; LDL Cholesterol; LDL Cholesterol Lipoproteins; Lipids; Lipoproteins, HDL Cholesterol; Low Density Lipoprotein Cholesterol; MGI-2; Measures; Metabolic; Metabolic Diseases; Metabolic Disorder; Mothers; Myeloid Differentiation-Inducing Protein; Novolin R; Nutritional; Obesity; Over weight; Overweight; Parents; Permission; Physical activity; Plasmacytoma Growth Factor; Population; Pregnancy; Raised TG; Raised triglycerides; Recruitment Activity; Relative; Relative (related person); Reporting; Research; Risk; Satiation; Satiations; Testing; Therapeutic Hormone; Thesaurismosis; Transmission; Treatment Side Effects; Triglyceride increased; Triglycerides high; United States; Visit; Weight; Woman; adiposity; alpha-Lipoprotein Cholesterol; beta-Lipoprotein Cholesterol; black American; blood glucose regulation; blood lipid; children; corpulence; corpulency; corpulentia; cytokine; diabetes of pregnancy; diabetes risk; disease risk; disorder risk; eight year old; elevated tg; elevated triglyceride; enroll; environmental intervention; fasted; fasts; feeding; ghrelin; glucagon-like peptide 1; glucose control; glucose homeostasis; glucose regulation; glucose tolerance; high risk; in utero; insulin resistant; insulin secretion; insulin sensitivity; interferon beta 2; metabolism disorder; obese; obese people; obese person; obese population; offspring; pediatric; prenatal exposure; prenatally exposed; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; recruit; satiety; side effect; therapy adverse effect; transmission process; treatment adverse effect; women of child bearing age; women of childbearing age; youngster",Effects of maternal obesity and gestational diabetes on offspring health,,82028,ZRG1,Special Emphasis Panel,,3,52154,
7996632,F32,DK,5,,01/01/2010,12/31/2010,PA-07-107,5F32DK082175-02,,NIDDK:50054;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DURHAM,UNITED STATES,BIOMEDICAL ENGINEERING,04,044387793,US,NC,27705,DUKE UNIVERSITY,"SNELLINGS, ANDRE ELLIOTT;",9300362;,5F32DK082175,01/01/2009,12/31/2010,"Afferent Neurons; Axon; Behavior; Biomimetics; Bladder; Bladder Control; Body Tissues; Cats; Cell Communication and Signaling; Cell Signaling; Characteristics; Code; Coding System; Corpuscula Lamellosa; Cutaneous; Data; Development; Devices; Disease; Disorder; Domestic Cats; Dorsal Root Ganglia; Electric Stimulation; Electrical Stimulation; Electrodes; Feedback; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fiber; Fire - disasters; Fires; Frequencies (time pattern); Frequency; Ganglia; Ganglia, Spinal; Ganglion Cysts; Ganglionic Cysts; Ganglions; Goals; H and E; Harvest; Hematoxylin and Eosin; Hematoxylin and Eosin Staining Method; Human; Human, General; Implant; Intracellular Communication and Signaling; Isometric Exercise; Isometrics; Lamellated Corpuscle; Length; Location; Lower urinary tract; Mammals, Cats; Man (Taxonomy); Man, Modern; Measures; Mediating; Medical Device; Methods and Techniques; Methods, Other; Micturition Reflex; Mimetics, Biological; Muscle-Setting Exercise; Myelopathy, Traumatic; Myxoid cyst; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Neural Cell; Neural Ganglion; Neurocyte; Neurological Damage; Neurological Injury; Neurological trauma; Neurons; Neurons, Afferent; Neurons, Sensory; Neuroreceptors; Pace Stimulators; Pacemakers; Pacinian Corpuscles; Pattern; Persons; Physiologic; Physiological; Plant Roots; Population; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Reagent; Receptor Protein; Receptors, Neural; Receptors, Sensory; Reflex; Reflex action; Research; Residual volume; Sensory; Sensory Cell Afferent Neuron; Sensory Receptors; Series; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord Trauma; Spinal Ganglia; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Staining method; Stainings; Stains; Static Exercise; Stimulators, Electrical, Pace; Stimulus; Structure; Techniques; Testing; Time; Tissues; Trauma, Nervous System; Travel; Tungsten; Urethra; Urethral sphincter; Urinary System, Bladder; Urination; Vater's Corpuscle; Vater-Pacini Corpuscle; W element; Wolfram; Work; afferent nerve; base; biological signal transduction; bladder continence; disease/disorder; dorsal root ganglion; experiment; experimental research; experimental study; fluid flow; information gathering; light microscopy; micturition; micturition control; neural; neural prosthesis; neural prosthetic; neuronal; pressure; receptor; relating to nervous system; research study; response; root; sensory nerve; uRNA; urethral; urinary; urinary bladder; urinary continence; urinary control; urination control; voiding; voiding reflex",Biomimetic stimulation of the sacral DRG to control continence and micturition,,82175,ZRG1,Special Emphasis Panel,,2,50054,
7692881,F32,DK,5,,01/01/2010,12/31/2010,PA-07-107,5F32DK083862-02,,NIDDK:50474;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,BIOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"KARPAC, JASON S;",9184917;,5F32DK083862,01/01/2009,12/31/2011,"21+ years old; ATF; Active Oxygen; Address; Adipose tissue; Adult; Affect; Aging; Analyses, Demographic; Analysis, Demographic; Assay; Autoregulation; Beta Cell; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Body Tissues; Cachectin Receptors; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Cues; Defect; Demographic Analyses; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Drosophila; Drosophila genome; Drosophila genus; Dysfunction; Dyslipidemias; EC 2.7; Endocrine; Endocrine Gland Secretion; Endocrinology; Fatty Tissue; Flies; Fruit Fly, Drosophila; Functional disorder; Gastrointestinal Tract, Pancreas; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Screening; Genetic Transcription; Genotype; Growth; Homeostasis; Hormonal; Hormones; Human; Human, Adult; Human, General; Humulin R; Inflammatory; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Resistance; Insulin Secreting Cell; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; Length of Life; Longevity; MAP Kinase Kinases; MAPK Kinases; MAPKKs; METBL; MODY; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolism; Metabolism and Endocrinology; Mitogen-Activated Protein Kinase Kinases; Monitor; Mortality; Mortality Vital Statistics; N-terminal; NH2-terminal; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutritional; Obesity; Organism; Oxidative Stress; Oxygen Radicals; Pancreas; Pancreatic; Pancreatic beta Cell; Pathway interactions; Peptides; Peripheral; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Physiology; Physiopathology; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pro-Oxidants; Production; Public Health; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reactive Oxygen Species; Receptor Protein; Regulation; Reporter; Reporting; Research Resources; Resources; Role; Screening procedure; Senescence; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Structure of beta Cell of islet; Subcellular Process; System; System, LOINC Axis 4; T2D; T2DM; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; Testing; Therapeutic Hormone; Thesaurismosis; Thioredoxin; Time; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transphosphorylases; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Type 2 diabetes; Type II diabetes; Vertebrate Animals; Vertebrates; Xenobiotics; activating transcription factor; adipose; adiposity; adult human (21+); adult onset diabetes; age dependent; age related; base; biological adaptation to stress; biological signal transduction; corpulence; corpulency; corpulentia; cytokine; design; designing; diabetes; experiment; experimental research; experimental study; fly; fruit fly; gain of function; genome, Drosophila; genome, fruit fly; in vivo; insight; insulin resistant; insulin signaling; ketosis resistant diabetes; life span; lifespan; living system; loss of function; maturity onset diabetes; metabolism disorder; novel; obese; obese people; obese person; obese population; ontogeny; overexpression; pancreas beta cell; pathophysiology; pathway; peroxiredoxin; prevent; preventing; public health medicine (field); reaction; crisis; receptor; research study; response; screening; screenings; senescent; social role; stress response; stress tolerance; stress; reaction; therapeutic target; vertebrata; white adipose tissue; yellow adipose tissue",Stress signaling in Insulin Producing Cells,,83862,ZRG1,Special Emphasis Panel,,2,50474,
7752541,F32,EY,5,,02/01/2010,01/31/2011,,5F32EY018512-02,,NEI:53810;,2010,NATIONAL EYE INSTITUTE,,OKLAHOMA CITY,UNITED STATES,ANATOMY/CELL BIOLOGY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"CONLEY, SHANNON M;",8706072;,5F32EY018512,02/01/2009,01/31/2012,"A Mouse; Accounting; Actins; Adhesion Molecule; Adhesions; Affinity; Affinity Chromatography; Annexin A2; Annexin II; Annexin II, P36; Apoptosis; Apoptosis Pathway; Au element; Binding; Binding (Molecular Function); Biochemical; Biological Models; Body Tissues; Bovine Species; Cadherins; Capactin I Heavy Chain; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell/Tissue, Immunohistochemistry; Cellular Adhesion; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular biology; Chromatography, Affinity; Co-Immunoprecipitations; Complementary DNA; Complex; Cone; Cones (Eye); Cones (Retina); Confocal Microscopy; Coupled; Cytoskeletal System; Cytoskeleton; DNA, Complementary; Data; Defect; Development; Disease; Disorder; Electron Microscopy; Genetic Alteration; Genetic Change; Genetic defect; Goals; Gold; Human; Human, General; IHC; Immune Precipitation; Immunoelectron Microscopy; Immunohistochemistry; Immunohistochemistry Staining Method; Immunoprecipitation; Internet; Interruption; Investigators; Knock-out; Knockout; Knockout Mice; Label; Leucine Zippers; Link; Lipid Rafts, Cell Membrane; Lipids; Lipocortin II; Liver Cell Adhesion Molecules; Macular degeneration; Macular degenerative disease; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane; Membrane Microdomains; Methods; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microscopy, Confocal; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Microtubules; Model System; Modeling; Models, Biologic; Molecular Interaction; Morphogenesis; Mouse Strains; Murine; Mus; Mutation; National Eye Institute; Neural Retina; Null Mouse; Outcome; PHEMX; PHEMX Protein; PHEMX protein, human; Pan-Hematopoietic Expression Protein; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Pigmentary Retinopathy; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteomics; Public Health; Radiolabeled; Regulation; Research; Research Personnel; Researchers; Retina; Retina Proper; Retinal; Retinal Cone; Retinal Degeneration; Retinitis Pigmentosa; Rod; Rod Outer Segment of the Retina; Rod Outer Segments; Rod Photoreceptors; Rod-Cone Dystrophy; Rods (Eye); Rods (Retina); Rods and Cones; Role; Saccharose; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; Subcellular Process; Sucrose; TSSC6; TSSC6 protein, human; Tapetoretinal Degeneration; Testing; Tetraspanin; Tissues; Transgenic Model; Tubular; Tubular formation; Tumor-Suppressing STF 6 Protein; Vertebrate Photoreceptors; Visual; Visual Receptor; WWW; Wild Type Mouse; Work; affinity purification; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; bovid; bovine; cDNA; cell adhesion protein; cell biology; cell type; cone cell; cow; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; human PHEMX protein; in vivo; inherited retinal degeneration; insight; interest; intracellular skeleton; lipid raft; liver cell adhesion molecule; membrane structure; mouse development; mouse model; palmitoylation; pan-hematopoietic expression protein, human; public health medicine (field); radiolabel; radiotracer; research study; retina degeneration; retinal degenerative; rod cell; rod outer segment; sedimentation velocity; social role; transcription factor; tumor suppressing subtransferable candidate 6 protein, human; web; world wide web",The role of the photoreceptor tetraspanin Rds in outer segment morphogenesis,,18512,ZRG1,Special Emphasis Panel,,2,53810,
7760863,F32,GM,5,,02/01/2010,07/31/2010,,5F32GM083463-03,,NIGMS:26077;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,NONE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"HAMEL, DAMON JUSTIN;",8959284;,5F32GM083463,02/01/2008,07/31/2010,"Adrenergic Receptor; Adrenoceptors; Affinity; Agonist; Assay; Atrophic Arthritis; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Bovine Species; C-C CKR-1 Gene; C-C CKR-5 Gene; C-C Chemokine Receptor Type 1 Gene; C-C Chemokine Receptor Type 5 Gene; C-X-C Chemokine Receptor Type 4; C-terminal; CC-CKR-1 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCR-1 Gene; CCR-5 Gene; CCR1; CCR1 gene; CCR5; CCR5 gene; CD184 Antigen; CD195 Antigen Gene; CHEMR13 Gene; CKR-1 Gene; CKR-5 Gene; CKR5 Gene; CMKBR1 Gene; CMKBR5 Gene; CMKR1 Gene; CXCR4 Receptors; Cancerous; Cancers; Cattle; Cell Locomotion; Cell Migration; Cell Movement; Cell membrane; Cells; Cellular Migration; Characteristics; Chemokine (C-C) Receptor 5 Gene; Chemokine (C-X-C Motif) Receptor 4; Chemokine, CXC Motif, Receptor 4; Choline Chloride Dihydrogen Phosphate; Choline Phosphate; Choline Phosphate Chloride; Codon; Codon Nucleotides; Coupled; Coupling; Crystallization; Crystallographies; Crystallography; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytokines, Chemotactic; Cytoplasmic Membrane; Data; Detergents; Development; Dimensions; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; ERBB2; ERBB2 gene; Environment; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride; Exposure to; Fibrosis; Fluorescence; Fluorescence Spectroscopy; Fluorescent Probes; Fusin; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Proteins; Generalized Growth; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Goals; Graft Rejection; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HDL; HER -2; HER-2; HER2; HER2/neu; HIV-1 Fusion Co-Receptor Gene; HM145 Gene; Heavy Lipoproteins; High Density Lipoproteins; High density lipoprotein; Homologous Chemotactic Cytokines; Human EGF Receptor 2 Gene; INFLM; Immune Surveillance; Immunologic Surveillance; Immunological Surveillance; Inflammation; Inflammatory Arthritis; Intercrines; Kidney; LD78 Receptor Gene; LPS-Associated Protein 3; Lead; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Ligand Binding; Ligands; Link; Lipids; Lipopolysaccharide-Associated Protein 3; Lipoproteins, HDL; MIP-1Alpha-R Gene; MIP1aR Gene; MS (Multiple Sclerosis); Macrophage Inflammatory Protein-1 Alpha Receptor Gene; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Measures; Mediating; Medication; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Methods and Techniques; Methods, Other; Micelles; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Motility; Motility, Cellular; Multiple Sclerosis; N-terminal; NH2-terminal; Neoplasm Metastasis; Neuropeptide Y Receptor Y3; P450; PTK Receptors; Particle Size; Pathology; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphatides; Phosphocholine; Phospholipids; Phosphorylcholine; Phosphorylcholine Chloride; Physiology; Plasma Membrane; Preparation; Probes, Fluorescent; Property; Property, LOINC Axis 2; Protein Gene Products; Proteins; Protocol; Protocols documentation; Publications; Publishing; RANTES Receptor Gene; RANTES-R Gene; RTK; Reaction; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Receptor, LESTR; Receptors, Epinephrine; Reporting; Rheumatoid Arthritis; Rhodopsin; SDF-1 Receptor; SDF1/PBSF Receptor CXCR4; SIS cytokines; Scaffolding Protein; Scientific Publication; Sclerosis, Disseminated; Secondary Neoplasm; Secondary Tumor; Seven-Transmembrane-Segment Receptor, Spleen; Signal Pathway; Sodium Butyrate; Solubility; Spectroscopy, Fluorescence; Stromal Cell-Derived Factor 1 Receptor; Structure; Surface; Surface Proteins; Surveillances, Immunologic; Surveillances, Immunological; Suspension substance; Suspensions; System; System, LOINC Axis 4; TKR1; Techniques; Technology; Time; Tissue Growth; Transmembrane Receptor Protein Tyrosine Kinase; Transplant Rejection; Transplantation Rejection; Tumor Cell Migration; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Urinary System, Kidney; Visual Purple; adenoreceptor; alpha-Lipoproteins; bovid; bovine; butyric acid, sodium salt; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer cell; cancer metastasis; cell motility; chemoattractant cytokine; chemokine; chemokine receptor; conformation; conformational state; cow; disease/disorder; drug discovery; drug/agent; experiment; experimental research; experimental study; expression vector; extracellular; fluorophore; gene product; heavy metal Pb; heavy metal lead; human disease; improved; insular sclerosis; malignancy; membrane structure; mimetics; nano meter scale; nano meter sized; nano scale; nanometer scale; nanometer sized; nanoscale; neoplasm/cancer; new technology; ontogeny; overexpression; particle; plasmalemma; protein expression; receptor; receptor function; receptor structure function; reconstitute; reconstitution; renal; research study; response; sodium butanoate; success; suspension",Nanodisc Reconstitution and Characterization of Chemokine Receptors,,83463,ZRG1,Special Emphasis Panel,,3,26077,
7762847,F32,GM,5,,02/01/2010,01/31/2011,PA-07-107,5F32GM083472-03,,NIGMS:50474;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,ENGINEERING (ALL TYPES),08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"PEYTON, SHELLY R;",8511506;,5F32GM083472,02/01/2008,01/31/2011,"21+ years old; 3-D; 3-Dimensional; Adhesions; Adult; Affect; Apoptosis; Apoptosis Pathway; Behavior; Biocompatible Materials; Biomaterials; Body Tissues; Bone Marrow; Cell Adhesion; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cell-Extracellular Matrix; Cells; Cellular Adhesion; Crossmatching, Tissue; ECM; EGF; EGF gene; EGFR; ERBB Protein; ERBB1; Environment; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Extracellular Matrix; Future; GFAC; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HER1; Histocompatibility Testing; Human, Adult; Hydrogels; Intracellular Communication and Signaling; Laboratories; Ligands; Macrogols; Mechanics; Mediating; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Methods; Mother Cells; PEG; Phenotype; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polyoxyethylenes; Progenitor Cells; Property; Property, LOINC Axis 2; Proteins; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Reticuloendothelial System, Bone Marrow; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stem cells; Surface; Testing; Time; Tissue Crossmatchings; Tissue Engineering; Tissue Typing; Tissues; Transforming Growth Factor alpha Receptor; URG; adult human (21+); analog; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cell behavior; cross-link; crosslink; design; designing; engineered tissue; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene product; histocompatibility typing; interest; novel; physical state; proto-oncogene protein c-erbB-1; response; scaffold; scaffolding; social role",Mesenchymal Stem Cell Behavior and Signaling in 3-D Synthetic ECM Analogs,,83472,ZRG1,Special Emphasis Panel,,3,50474,
7762846,F32,GM,5,,02/01/2010,01/31/2011,,5F32GM083548-03,,NIGMS:52154;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SANTA CRUZ,UNITED STATES,BIOCHEMISTRY,17,125084723,US,CA,95064,UNIVERSITY OF CALIFORNIA SANTA CRUZ,"PETRELLA, LISA NICOLE;",8954107;,5F32GM083548,02/01/2008,01/31/2011,"Affinity; Antigenic Determinants; Binding Determinants; Biochemical; C elegans; C elegans Proteins; C.elegans; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cancers; Candidate Disease Gene; Candidate Gene; Cell Body; Chromatin; Development; Disease; Disorder; Epitopes; Gene Expression; GeneHomolog; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Germ Lines; Homolog; Homologous Gene; Homologue; Human; Human, General; Lead; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mutate; Mutation; Pathway interactions; Pb element; Phenotype; Process; Proteins; Regulation; Research; Role; SET Domain; System; System, LOINC Axis 4; Testing; Work; X Chromosome; Yeasts; autosome; cell body (neuron); disease/disorder; gene product; genome mutation; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; malignancy; mutant; neoplasm/cancer; neural cell body; neuronal cell body; overexpression; overexpression analysis; pathway; social role; soma",Chromatin Regulation in C. elegans Germline Development,,83548,ZRG1,Special Emphasis Panel,,3,52154,
7755843,F32,GM,5,,01/01/2010,12/31/2010,,5F32GM083581-02,,NIGMS:47606;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLOOMINGTON,UNITED STATES,BIOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"KYSELA, DAVID ;",8969584;,5F32GM083581,01/01/2009,12/31/2011,"Address; Age; Aged 65 and Over; Aging; Aging Process; Aging-Related Process; Bacteria; Bacterial Infections; Bacterial Physiology; Biological Models; Birth; Caulobacter; Caulobacter crescentus; Cell Aging; Cell Senescence; Cells; Cellular Aging; Daughter; Deterioration; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elderly; Elderly, over 65; Ensure; Eukaryota; Eukaryote; Evolution; Gene Transcription; Genetic Transcription; Human; Human, General; Label; Life; Link; Man (Taxonomy); Man, Modern; Measures; Mitochondria; Model System; Models, Biologic; Mothers; Neptunium; Organism; Output; Parturition; Physiologic; Physiological; Physiology; Population; RNA Expression; Racial Segregation; Reproduction; Reproductive Process; Research; Senescence; Senescence, Cellular; Senescence, Replicative; Transcription; Transcription, Genetic; advanced age; analog; bacterial disease; base; cell age; comparative; daughter cell; elders; eukaryotida; experiment; experimental research; experimental study; geriatric; improved; late life; later life; living system; macromolecule; mitochondrial; mutant; older adult; older person; oxidative damage; protein expression; public health relevance; reproductive; research study; segregation; senescent; senior citizen; trafficking",Aging in appendaged bacteria,,83581,ZRG1,Special Emphasis Panel,,2,47606,
7750033,F32,GM,5,,01/01/2010,02/06/2010,,5F32GM083622-03,,NIGMS:8187;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,CHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"FIORI, KRISTIN WILLIAMS;",9042506;,5F32GM083622,01/01/2008,02/06/2010,"Alcohols; Amino Sugars; Azides; Biochemical; Biological; Cancers; Carbohydrates; Cells; Charge; Chemical Class, Alcohol; Code; Coding System; Complex; Deoxy Sugars; Engineering; Engineerings; Esters; Generalized Growth; Genetic; Glycans; Glycosaminoglycans; Growth; Histidine; Histidine, L-isomer; Human Development; Hydrogen Bonding; Inorganic Sulfates; Kinetic; Kinetics; L-Histidine; Libraries; Malignant Neoplasms; Malignant Tumor; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Methods and Techniques; Methods, Other; Monosaccharides; Mucopolysaccharides; Neoplasm Metastasis; Oligopeptides; Oligosaccharides; Organism-Level Process; Organismal Process; PSGAG; Pattern; Peptides; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Polysaccharides; Position; Positioning Attribute; Regulation; Secondary Neoplasm; Secondary Tumor; Series; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Techniques; Tissue Growth; Tumor Cell Migration; Unspecified or Sulfate Ion Sulfates; Viral; Work; aminosugar; analog; base; cancer metastasis; catalyst; deoxysugar; design; designing; glycosaminoglycan polysulfate; glycosaminoglycan polysulfuric acid ester; glycosaminoglycan polysulphate; improved; malignancy; method development; monomer; neoplasm/cancer; neuronal growth; novel; ontogeny; polyol; polysulfated glycosaminoglycan; sugar; sulfate; sulfated glycosaminoglycan; sulfation",Development of Methods for the Efficient Synthesis of Sulfated Polysaccharides,,83622,ZRG1,Special Emphasis Panel,,3,8187,
7790556,F32,GM,5,,02/01/2010,01/31/2011,,5F32GM086027-02,,NIGMS:50474;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EUGENE,UNITED STATES,OTHER BASIC SCIENCES,04,948117312,US,OR,97403,UNIVERSITY OF OREGON,"NICHOLS, JAMES TUCKER;",9309695;,5F32GM086027,02/01/2009,01/31/2012,"Address; Adhesions; Adopted; Animals; Articulation; Biological; Biological Models; Biology; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Brachydanio rerio; Branchial Arches; Branchial arch structure; Cancer Cause; Cancer Etiology; Cancers; Cartilage; Cartilagenous Tissue; Cell Communication; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Interaction; Cell Isolation; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cell physiology; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular biology; Cephalic; Chondrocytes; Complex; Connective Tissue; Cranial; Danio rerio; Development; Disease; Disorder; Dorsal; Dose; EPH; Ectopic Expression; Elements; Ensure; Eph Family Receptors; Eph Receptor Ligands; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Ephrins; Event; FISH Technic; FISH Technique; FISH analysis; First Pharyngeal Arch; Fluorescent in Situ Hybridization; Fostering; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Human; Human, General; In Situ Hybridization, Fluorescence; Intracellular Communication and Signaling; Jaw Joint; Joints; Knowledge; Label; Larva; Ligands; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mandibular joint; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Monitor; Morphogenesis; Mother Cells; Motility; Motility, Cellular; Mutation; Neural Crest Cell; Peptide Signal Sequences; Pharangeal Arch; Pharyngeal Arches; Phenotype; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Public Health; Racial Segregation; Receptor Protein; Receptors, Eph Family; Role; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Skeleton; Specific qualifier value; Specified; Stem cells; Structure; Subcellular Process; System; System, LOINC Axis 4; TMJ; Temporomandibular Joint; Testing; Therapeutic; Tissues; To specify; Visceral Arches; Work; Zebra Danio; Zebra Fish; Zebrafish; base; biological signal transduction; bone; branchial arch; cell biology; cell motility; cell sorting; cell type; craniofacial; craniofacies; disease/disorder; experiment; experimental research; experimental study; gene discovery; gene function; genome mutation; human disease; intercellular communication; interest; loss of function; malignancy; migration; mutant; neoplasm/cancer; pharyngeal arch; precursor cell; prevent; preventing; programs; protein signal sequence; public health medicine (field); receptor; research study; segregation; skeletal; social role; stem; tool",The Molecular Genetics and Cell Biology of Jaw Joint Morphogenesis,,86027,ZRG1,Special Emphasis Panel,,2,50474,
7762832,F32,GM,5,,02/01/2010,01/31/2011,PA-07-107,5F32GM086949-02,,NIGMS:50474;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MATRANGA, CHRISTIAN ;",9427517;,5F32GM086949,02/01/2009,01/31/2012,"ATP Hydrolysis; ATP phosphohydrolase; ATPase; Adenosine Triphosphatase; Adenosinetriphosphatase; Animals; Area; Binding; Binding (Molecular Function); Biological Models; C elegans; C.elegans; Caenorhabditis elegans; Cancer Cause; Cancer Etiology; Crystallographies; Crystallography; DICER1; DICER1 Protein; DICER1 protein, human; DNA; DNA Helicases; DNA Unwinding Proteins; DNA unwinding enzyme; Dcr-1 Homolog; Deoxyribonucleic Acid; Dicer; Dicer1, Dcr-1 homolog (Drosophila) protein, human; Double-Stranded RNA; EC 3.1.26.-; Endoribonuclease Dicer; Enzymes; Evolution; Gene Action Regulation; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; GeneHomolog; Goals; HERNA; HERNA protein, human; Helicase with RNase Motif; Helicase-MOI; Homolog; Homolog of Drosophila Dicer; Homologous Gene; Homologue; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Institutes; Intermediary Metabolism; K12H4.8-Like; KIAA0928; Laboratories; METBL; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Medical; Metabolic Processes; Metabolism; Micro RNA; MicroRNAs; Model System; Models, Biologic; Molecular Interaction; Natural Immunity; Pathway interactions; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Production; Protein Biochemistry; Protein/Amino Acid Biochemistry; Proteins; Putative RNA-Binding Region; Quelling; RBD; RNA; RNA Binding Domain; RNA Helicase; RNA Interference; RNA Interference Pathway; RNA Recognition Motif; RNA Silencing; RNA Silencings; RNA polymerase III transcription; RNA, Double-Stranded; RNA, Non-Polyadenylated; RNA, Small Interfering; RNA, Viral; RNAi; RNP Domain; RNP Motif; RNP-1 Signature; RRM; Ribonucleic Acid; Role; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Small RNA; Specificity; System; System, LOINC Axis 4; Universities; Viral Diseases; Virus; Virus Diseases; Viruses, General; Work; dsRNA; gene product; helicase; host response; human DICER1 protein; immunoresponse; interest; member; miRNA; mutant; pathway; plant fungi; protein expression; protein protein interaction; response; siRNA; social role; triphosphate; tripolyphosphate; viral RNA; viral infection; virus RNA; virus infection",Investigating the role of RNA helicases in RNAi and innate immunity,,86949,ZRG1,Special Emphasis Panel,,2,50474,
7766957,F32,GM,5,,02/01/2010,10/31/2010,,5F32GM087005-02,,NIGMS:39818;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"SINSIMER, KRISTINA SUTPHEN;",9296599;,5F32GM087005,02/01/2009,10/31/2010,"3' Untranslated Regions; 3'UTR; Affinity Chromatography; Anterior; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Biochemical; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chromatography, Affinity; Cis-Acting Locus; Cis-Acting Sequence; Combining Site; Complex; Coupled; Data; Defect; Development; Disease; Disorder; Drosophila; Drosophila genus; Elements; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Ensure; Eukaryote; Eukaryotic Cell; Fruit Fly, Drosophila; Gene Expression; Gene Products, RNA; GeneHomolog; Genetic; Goals; Homolog; Homologous Gene; Homologue; Intracellular Communication and Signaling; Investigation; Lead; Ligand Binding Protein; Malignant Neoplasms; Malignant Tumor; Mediating; Messenger RNA; Methods; Molecular Interaction; Oocytes; Ovarian; Ovocytes; Pb element; Process; Proteins; RNA; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Binding Proteins; RNP; Reactive Site; Regulation; Ribonucleic Acid; Ribonucleoproteins; Role; Signal Transduction; Signal Transduction Systems; Signaling; Trans-Acting Factors; Trans-Activators; Transactivators; Translational Inhibition; Translational Repression; Translations; Work; affinity purification; biological signal transduction; disease/disorder; eukaryotida; experiment; experimental research; experimental study; fruit fly; gene product; heavy metal Pb; heavy metal lead; insight; mRNA; malignancy; neoplasm/cancer; prevent; preventing; protein complex; protein expression; research study; social role; trans acting factor (genetic)",Identification of nanos mRNA localizatino factors in Drosophila,,87005,ZRG1,Special Emphasis Panel,,2,39818,
7769866,F32,GM,5,,02/01/2010,01/31/2011,PA-07-107,5F32GM087006-02,,NIGMS:50474;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"PAIS, JUNE ELIZABETH;",9406457;,5F32GM087006,02/01/2009,01/31/2012,"ATP Hydrolysis; ATP phosphohydrolase; ATPase; Adenosine Triphosphatase; Adenosinetriphosphatase; Aging; Amino Acids; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Biochemical; Biogenesis; Calcium Ion Signaling; Calcium Signaling; Cancers; Cardiac Diseases; Cardiac Disorders; Cell Death, Programmed; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chaperone; Complex; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytosol; Development; Diabetes Mellitus; Environment; Fe element; Genetics-Mutagenesis; HSP; Heart Diseases; Heat shock proteins; In Vitro; Inner mitochondrial membrane; Integral Membrane Protein; Intermediary Metabolism; Intrinsic Membrane Protein; Iron; Lipids; METBL; Malignant Neoplasms; Malignant Tumor; Membrane; Membrane Potentials; Metabolic; Metabolic Processes; Metabolism; Mitochondria; Mitochondrial Matrix; Mitochondrial Proteins; Molecular Biology, Mutagenesis; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Motor; Movement; Mutagenesis; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Organelles; Organism; Origin of Life; Peptides; Physiologic; Physiological; Process; Protein Import; Protein translocation; Proteins; Public Health; Regulation; Research; Research Proposals; Resting Potentials; Ribosomes; Role; S element; Senescence; Single Crystal Diffraction; Stress Proteins; Structure; Subcellular Process; Sulfur; Transmembrane Potentials; Transmembrane Protein; Transmembrane Protein Transport; X Ray Crystallographies; X-Ray Crystallography; Yeasts; aminoacid; base; body movement; cell biology; conformation; conformational state; diabetes; gene product; heart disorder; human disease; living system; malignancy; membrane structure; mitochondrial; neoplasm/cancer; nervous system disorder; neurological disease; polypeptide; prevent; preventing; public health medicine (field); reconstitute; reconstitution; senescent; social role; technique development; translocase; yeast genetics",Mechanism and regulation of the Hsp70-based mitochondrial protein import motor,,87006,ZRG1,Special Emphasis Panel,,2,50474,
7787484,F32,GM,5,,02/01/2010,01/31/2011,,5F32GM087102-02,,NIGMS:47606;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PASADENA,UNITED STATES,ENGINEERING (ALL TYPES),29,009584210,US,CA,91125,CALIFORNIA INSTITUTE OF TECHNOLOGY,"BRUSTAD, ERIC MICHAEL;",9430031;,5F32GM087102,02/01/2009,01/31/2011,"1,4-dihydropyridine; Antibiotic Resistance; Arabinose; Bacillus; Bacillus (bacterium); Be element; Be++ element; Benzodiazepine Compounds; Benzodiazepines; Beryllium; Binding; Binding (Molecular Function); Biological; CYP; Cell Survival; Cell Viability; Chemicals; Chemistry, Organic; Cleaved cell; Couples; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytochromes; Development; Dihydropyridines; Disadvantaged; Dissociation; Drugs; Elements; Engineering; Engineerings; Enzymes; Evolution; Family; Gene Transcription; General Practitioners; Generalists; Generalized Growth; Genes; Genetic Transcription; Growth; High Throughput Assay; Hydrogen Bonding; Hydroxylases; Hydroxylation; L-Arabinose; Lead; Libraries; Ligands; Link; Location; Medication; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mixed Function Oxidases; Mixed Function Oxygenases; Molecular; Molecular Interaction; Monooxygenases; Nature; Organic Chemistry; P450; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Procedures; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Protocol; Protocols documentation; RNA Expression; Reaction; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resolution; Screening procedure; Site; Solutions; Specificity; Structure; System; System, LOINC Axis 4; Techniques; Therapeutic; Time; Tissue Growth; Transcription; Transcription, Genetic; Transition Elements; antibiotic resistant; catalyst; cleaved; cost; design; designing; dihydropyridine; directed evolution; drug discovery; drug/agent; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; high throughput screening; improved; interest; molecular recognition; mutant; novel; ontogeny; oxidation; public health relevance; research study; response; scaffold; scaffolding; screening; screenings; small molecule; transition metal",Evolution of cytochrome p450s for the diversification of drug scaffolds,,87102,ZRG1,Special Emphasis Panel,,2,47606,
7760038,F32,HD,5,,02/28/2010,02/27/2011,,5F32HD057695-03,,NICHD:53947;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,AUSTIN,UNITED STATES,PSYCHOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"HOFFMAN, AARON B;",7991392;,5F32HD057695,02/28/2008,02/27/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; AD/HD; ADHD; Area; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Basal Ganglia; Basal Nuclei; Bears; Behavior; Behavioral; Brain; Categories; Clinical; Cognitive; Data; Data Set; Dataset; Decision Making; Diagnosis; Dopamine; Encephalon; Encephalons; Environment; Eye; Eye Movements; Eyeball; Gambling; Gamblings; Goals; Government; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Idiopathic Parkinson Disease; Institution; Kanner's Syndrome; Learning; Learning, Machine; Lewy Body Parkinson Disease; Light; Link; Literature; Machine Learning; Man (Taxonomy); Man, Modern; Maps; Measures; Mediating; Methods and Techniques; Methods, Other; Modeling; Nervous System, Brain; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Photoradiation; Population; Position; Positioning Attribute; Primary Parkinsonism; Problem Solving; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Psychological reinforcement; Reading; Reinforcement; Reinforcement (Psychology); Research; Role; Sampling; Structure; Techniques; Training; Universities; Ursidae; Ursidae Family; Work; attention deficit hyperactive disorder; experience; experiment; experimental research; experimental study; frontal cortex; frontal lobe; improved; information processing; kernel methods; public health relevance; research study; social role; statistical learning; support vector machine",Category Learning in Dynamic Environments,,57695,ZRG1,Special Emphasis Panel,,3,53947,
7779979,F32,HD,5,,02/01/2010,01/31/2011,PA-07-107,5F32HD060369-02,,NICHD:47606;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BALTIMORE,UNITED STATES,BIOMEDICAL ENGINEERING,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KEISLER, AYSHA S;",8628600;,5F32HD060369,02/01/2009,01/31/2011,"Accounting; Affect; Attention; Awareness; Awarenesses; Cognitive Discrimination; Controlled Study; Discrimination; Discrimination (Psychology); Impairment; Lead; Learning; Light; Measures; Memory; Motor; Motor Skills; Participant; Patient Schedules; Patients; Pattern; Pb element; Performance; Photoradiation; Physical Health Services / Rehabilitation; Process; Reaction Time; Reading; Rehabilitation; Rehabilitation Research; Rehabilitation therapy; Rehabilitation, Medical; Research; Response RT; Response Time; Sleep; Sleep Deprivation; System; System, LOINC Axis 4; Testing; Time; Training; deprivation; experience; forgetting; heavy metal Pb; heavy metal lead; improved; motor control; neglect; psychomotor reaction time; rehab strategy; rehabilitation strategy; rehabilitative; sequence learning; skill acquisition; vigilance",Post-acquisition changes in motor skill representation,,60369,ZRG1,Special Emphasis Panel,,2,47606,
7688524,F32,HL,5,,01/01/2010,12/31/2010,,5F32HL085980-02,,NHLBI:53810;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SIOUX FALLS,UNITED STATES,,00,050113252,US,SD,57105,SANFORD RESEARCH/USD,"WRIGHT, CASEY D;",8436226;,5F32HL085980,01/01/2009,12/31/2011,"21+ years old; Adrenergic Antagonists; Adrenergic Blockaders; Adrenergic Blockers; Adrenergic Receptor; Adrenergic Receptor Blockaders; Adrenergic-Blocking Agents; Adrenoceptors; Adrenolytic Agents; Adrenolytic Drugs; Adrenolytics; Adult; Anti-Adrenergics; Antiadrenergic Agents; Antiadrenergics; Assay; Bioassay; Biologic Assays; Biological Assay; Blotting, Western; Cardiac Myocytes; Cardiocyte; Caveolae; Caveolas; Cell Communication and Signaling; Cell Death; Cell Nucleus; Cell Signaling; Cell membrane; Clinical Trials; Clinical Trials, Unspecified; Cytoplasmic Membrane; EC 2.7; G Protein-Coupled Receptor Signaling; GPCR Signaling; Goals; Growth and Development; Growth and Development function; HTRPY; Heart; Heart failure; Heart myocyte; Human, Adult; Hypertrophy; Intracellular Communication and Signaling; Isoenzymes; Isozymes; Kinases; Knock-out; Knockout; Left; M-caveolin; MAP-ERK Kinase; MAPK ERK Kinases; MEKs; Mammals, Mice; Mediating; Mice; Modeling; Molecular; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocardial; Myocytes; Myocytes, Cardiac; Nuclear; Nuclear Envelope; Nuclear Membrane; Nucleus; Pathway interactions; Phosphorylation; Phosphotransferases; Plasma Membrane; Protein Phosphorylation; Proteins; Ras/Raf; Receptor Antagonists, Adrenergic; Receptor Signaling; Receptors, Epinephrine; Research; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Stream; Stress; Testing; Transphosphorylases; Western Blotting; Western Blottings; Western Immunoblotting; adenoreceptor; adult human (21+); biological signal transduction; cardiac failure; cardiomyocyte; caveolin-3; clinical investigation; gene product; immunocytochemistry; necrocytosis; pathway; plasmalemma; protein blotting; response; social role",Nuclear alpha1-Adrenergic Receptor Signaling in Adult Mouse Cardiace Myocytes,,85980,ZRG1,Special Emphasis Panel,,2,53810,
7763822,F32,HL,5,,01/01/2010,12/31/2010,,5F32HL091642-03,,NHLBI:52154;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,ANATOMY/CELL BIOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"LEDFORD, JULIE GUNNELLS;",6989799;,5F32HL091642,01/01/2008,12/31/2010,"A Mouse; ATGN; Accounting; Acute; Affinity; Airway Hyper-responsiveness; Allergens; Allergic; Allergic asthma; Alveolar Macrophages; Antigens; Assay; Asthma; Attenuated; Bacteria; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bone Marrow; Bronchial Asthma; Bronchioalveolar Lavage; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; COAD; COPD; Cell Culture Techniques; Cell Function; Cell Maturation; Cell Process; Cell physiology; Cell surface; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Communities; Conditioned Culture Media; Conditioned Medium; Confocal Microscopy; Culture Media, Conditioned; Cytofluorometry, Flow; Cytotoxic cell; Dendritic Cells; Development; Disease; Disorder; Eaton Agent; Eaton Liu agent; Environmental Factor; Environmental Risk Factor; Eperythrozoon; Epithelial; Extrinsic asthma; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Garamicin; Garamycin; General Population; General Public; Generalized Growth; Genoptic; Genoptic S.O.P.; Gentamicins; Growth; Haemobartonella; Heterophil Granulocyte; Host Defense; Human; Human, General; INFLM; Immune system; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; In Vitro; Infection; Inflammation; Inflammatory; Investigation; K lymphocyte; Knockout Mice; LPS; Lavage, Bronchopulmonary; Link; Lipopolysaccharides; Lung; Lung Lavage; Lung diseases; M. pneumoniae; Macrophages, Alveolar; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Microbe; Microfluorometry, Flow; Microscopy, Confocal; Modeling; Molecular Interaction; Murine; Mus; Mycoplasma; Mycoplasma pneumoniae; NK Cells; Natural Immunity; Natural Killer Cells; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Opsonin; Ovalbumin; Pathogenicity; Patients; Phagocytosis; Play; Pneumonia; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Production; Proteins; Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; Pulmonary Macrophages; Pulmonary Surfactant-Associated Protein A; Research; Research Design; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Role; SP-A Protein; Study Type; Subcellular Process; Surfactant Protein A; Symptoms; Testing; Tissue Growth; U-Gencin; Veiled Cells; Virus; Viruses, General; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; atopic asthma; atypical pneumonia; body system, allergic/immunologic; bronchopulmonary lavage therapy; cytokine; disease/disorder; environmental risk; experiment; experimental research; experimental study; extrinsic allergic asthma; flow cytophotometry; gene product; immunogen; in vivo; lung disorder; macrophage; microbial; neutrophil; ontogeny; organ system, allergic/immunologic; pathogen; pulmonary; research study; resistant; response; social role; study design; surfactant; uptake",Role of Surfactant in Mycoplasma Pulmonary Infection and Exacerbation,,91642,ZRG1,Special Emphasis Panel,,3,52154,
7689917,F32,HL,5,,12/01/2009,11/30/2010,PA-07-107,5F32HL094025-02,,NHLBI:30692;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCHESTER,UNITED STATES,PSYCHIATRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"SPAGNOLA, MARY ELIZABETH;",9302422;,5F32HL094025,09/16/2008,11/30/2010,"0-11 years old; 8 year old; ADRGND; Accident and Emergency department; Adopted; Adrenal Glands; Adrenals; Aeroseb-HC; Area; Asthma; Award; Biological; Bronchial Asthma; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cetacort; Child; Child Youth; Child health care; Childhood; Children (0-21); Chronic Disease; Chronic Illness; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Conflict; Conflict (Psychology); Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Data; Dermacort; Development; Diagnosis; Disease; Disorder; Eldecort; Emergency Department; Emergency room; Family; Future; Goals; HOSP; HPA; Health, Child; Hospitalization; Human, Child; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; Individual Differences; Intervention; Intervention Strategies; Interview; Investigators; Knowledge; Link; Low income; Measures; Mediating; Medical; Medical center; Minority; Modeling; Models, Theoretic; Morbidity; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Nature; Nervous System, Pituitary; Nutracort; Outcome; Pattern; Physiologic; Physiological; Pituitary; Pituitary Gland; Play; Predisposing Factor; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Prevalence; Process; Proctocort; Programs (PT); Programs [Publication Type]; Psychosocial Stress; Questionnaires; Research; Research Personnel; Researchers; Risk; Role; Sampling; Schools; Severities; Social Environment; Stress; Symptoms; System; System, LOINC Axis 4; Testing; Theoretical model; Therapeutic Hydrocortisone; Training; Uncertainty; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Variant; Variation; Visit; base; biopsychosocial; career; child well being; children; chronic disease/disorder; chronic disorder; clinical investigation; clinical test; disease/disorder; doubt; eight year old; experience; high risk; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; indexing; interest; intervention program; interventional strategy; medical complication; pediatric; programs; psychosocial; research clinical testing; skills; social climate; social context; social role; socioenvironment; stressor; suprarenal gland; youngster",Family Psychosocial Stress and HPA Axis Reactivity in Children with Asthma,,94025,ZRG1,Special Emphasis Panel,,2,30692,
7768477,F32,HL,5,,02/01/2010,01/31/2011,,5F32HL095241-02,,NHLBI:51710;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,BIOCHEMISTRY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"CARLSON, ANNE E;",7249286;,5F32HL095241,02/01/2009,01/31/2012,"Action Potentials; Affect; Arrhythmia; Binding; Binding (Molecular Function); Binding Sites; Brain; Cancers; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cause of Death; Central Nervous System; Cessation of life; Combining Site; DNA Molecular Biology; Death; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Ethers; Exhibits; Family; Functional disorder; Genes; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Goals; Heart; Heart Arrhythmias; Heart Diseases; Human; Human, General; Ion Channels, Potassium; K channel; K element; Learning; Libraries; Ligand Binding; Long QT Syndrome; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Memory; Molecular Biology; Molecular Interaction; Mutation; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurophysiology / Electrophysiology; Orphan; Pathology; Pathway interactions; Physiology; Physiopathology; Play; Potassium; Potassium Channel; Process; Property; Property, LOINC Axis 2; Protein Biochemistry; Protein Family; Protein/Amino Acid Biochemistry; Reactive Site; Receptor Protein; Role; Site; Stimulus; United States; disease/disorder; experiment; experimental research; experimental study; genetic analysis; genome mutation; heart disorder; malignancy; member; neoplasm/cancer; patch clamp; pathophysiology; pathway; receptor; research study; response; small molecule libraries; social role",A Regulator for Eag Family Channels,,95241,ZRG1,Special Emphasis Panel,,2,51710,
7784465,F32,HL,5,,12/15/2009,12/14/2010,,5F32HL095353-02,,NHLBI:50474;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"DAVIS, JENNIFER ;",9429532;,5F32HL095353,12/15/2008,12/14/2011,"21+ years old; Acute; Adrenergic Agents; Adrenergic Drugs; Adrenergics; Adult; American; Biology; Body Tissues; Calcineurin; Calcineurin antagonist; Calcineurin inhibitor; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiac Remodeling, Ventricular; Cardiocyte; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Common Rat Strains; Coupling; Critical Paths; Critical Pathways; Death; Development; Diagnosis; Gene Expression; Gene Transcription; Gene Transfer; Generalized Growth; Genetic; Genetic Models; Genetic Transcription; Grant; Growth; HTRPY; Heart; Heart Diseases; Heart failure; Heart myocyte; Human, Adult; Hypertrophy; In Vitro; Intracellular Communication and Signaling; Investigation; Language; Left Ventricular Function; Mammals, Mice; Mammals, Rats; Measurement; Mediating; Mice; Models, Genetic; Molecular; Morphology; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle function; Muscle, Cardiac; Muscle, Heart; Myocardial Remodeling, Ventricular; Myocardium; Myocytes; Myocytes, Cardiac; Outcome; PP2B; Pathologic; Pathway interactions; Performance; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Physiologic; Physiological; Play; Process; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphatase-2B; Protein Phosphorylation; Protein phosphatase; Proteins; Proteomics; RNA Expression; RNA, Small Interfering; Rat; Rattus; Regulation; Relaxation; Reporting; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Staging; Stress; Structure; Subcellular Process; Testing; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transgenes; Ventricle Remodeling; Ventricular; Ventricular Function; Ventricular Function, Left; Ventricular Remodeling; Work; adrenergic; adult human (21+); biological signal transduction; cardiac failure; cardiac muscle; cardiomyocyte; cardiovascular disorder; comparative; design; designing; functional outcomes; gene product; heart disorder; heart muscle; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; mouse model; myocardial remodeling; new growth; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; pathway; premature; response; siRNA; social role; transfer of a gene; ventricular hypertrophy",The non-hypertrophic role of calcineurin in regulating cardiac structure-function,,95353,ZRG1,Special Emphasis Panel,,2,50474,
7783863,F32,MH,5,,03/10/2010,03/09/2011,,5F32MH080524-03,,NIMH:55790;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PRINCETON,UNITED STATES,PSYCHOLOGY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"SIMEN, PATRICK A;",7261930;,5F32MH080524,03/10/2008,03/09/2011,"Accounting; Address; Affect; Animals; Area; Au element; Behavioral; Bereitschaftspotential; Brain; Cell Communication and Signaling; Cell Signaling; Classification; Cognitive; Cognitive Discrimination; Complement; Complement Proteins; Contingent Negative Variation; Controlled Study; Data; Decision Making; Decision Modeling; Diffusion; Discrimination; Discrimination (Psychology); Encephalon; Encephalons; Evaluation; Event; Event-Related Potentials; Eye Movements; Functional Magnetic Resonance Imaging; Goals; Gold; Human; Human, General; Imaging Procedures; Imaging Techniques; Injury; Intracellular Communication and Signaling; Intraparietal Sulcus; Laboratories; Lateral; Lead; Level of Evidence; Location; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Modality; Modeling; Modeling, Decision; Monitor; Motion; Motion Perception; Motor Cortex; Movement; NRSA; National Research Service Awards; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Outcome; Output; Pattern; Pb element; Performance; Preparation; Process; Psychiatric Disease; Psychiatric Disorder; Pursuit, Saccadic; Ramp; Readiness Potential; Resolution; Response to stimulus physiology; Rewards; Saccades; Saccadic Eye Movements; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Source; Speed; Speed (motion); Staging; Stimulus; Structure of intraparietal sulcus; Systematics; Technics, Imaging; Techniques; Temporal Lobe; Testing; Time; Unspecified Mental Disorder; Visual Motion; Work; abstracting; area MT; area V5; base; biological signal transduction; body movement; cognitive control; cost; data modeling; design; designing; encephalography; event related potential; experiment; experimental research; experimental study; fMRI; frontal eye fields; heavy metal Pb; heavy metal lead; imaging modality; intraparietal sulcus; mental illness; neural circuit; neural circuitry; neural mechanism; neuromechanism; neuronal; non-human primate; nonhuman primate; psychological disorder; research study; response; reward processing; sensory integration; stimulus/response; temporal cortex; temporal lobe/cortex",NRSA: Dynamic evaluation and control of decision making,,80524,ZRG1,Special Emphasis Panel,,3,55790,
7771775,F32,MH,5,,02/15/2010,02/14/2011,PA-07-107,5F32MH084788-02,,NIMH:47606;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SEATTLE,UNITED STATES,PSYCHIATRY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"LANDES, SARA JAMES;",9263563;,5F32MH084788,02/15/2009,02/14/2011,"Adherence; Adherence (attribute); After Care; After-Treatment; Aftercare; BPD; Behavior; Behavior Disorders; Behavioral; Borderline Personality Disorder; Client; Code; Coding System; Collection; Continuance of education; Continuing Education; Data; Development; Dialectical behavior therapy; Education, Continuing; Effectiveness; Enrollment; Expenditure; Feasibility Studies; Future; Health Services; Interview; Investigation; Knowledge; Link; Measures; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Method LOINC Axis 6; Methodology; Methods; Mind; Mission; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Outcome; Pathway interactions; Phone; Problem-Based Learning; Process; Program Development; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychotherapy; Public Health; RGM; Regimen; Research; Research Training; Science; Services; Structure; Symptoms; Telephone; Time; Training; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States National Institute of Mental Health; Unspecified Mental Disorder; base; behavioral disorder; brain behavior; design; designing; dissemination research; efficacy trial; enroll; experience; experiment; experimental research; experimental study; function improvement; functional improvement; health care service; improved; innovate; innovation; innovative; mental illness; non-suicidal self injury; pathway; programs; psychological disorder; public health medicine (field); research study; suicidal behavior; suicide behavior; therapy adherence",Impact of Intensive Dialectical Behavior Therapy Training on Therapist Behavior,,84788,ZMH1,Special Emphasis Panel,,2,47606,
7758255,F32,NS,5,,02/01/2010,01/31/2011,PA-06-373,5F32NS059205-03,,NINDS:59918;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ELYAMAN, WASSIM ;",8295485;,5F32NS059205,02/01/2008,01/31/2011,"ATGN; Affect; Antibodies; Antigens; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Maturation; Cell Process; Cell Signaling; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Chimera Protein; Chimeric Proteins; Data; Development; Disease; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Fusion Protein; Generations; Goals; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immuno-Chemotherapy; Immunochemotherapy; Immunologic Diseases; Immunological Diseases; Immunotherapy, Cancer, General; In Vitro; Inflammatory; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; Lead; Ligands; MS (Multiple Sclerosis); Mammals, Mice; Mediating; Methods; Mice; Moab, Clinical Treatment; Modeling; Molecular; Monoclonal Antibodies; Monoclonal Antibody Therapy; Multiple Sclerosis; Murine; Mus; Myelin; Myeloencephalitis; Nervous System, CNS; Neuraxis; Pathway interactions; Pb element; Peripheral; Play; Regulatory T-Lymphocyte; Reporter; Role; Sclerosis, Disseminated; Self-Antigens; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Study models; Subcellular Process; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Th-1 Cell; Th1 Cells; Therapeutic; Thymus-Dependent Lymphocytes; Transplantation; Type 1 Helper Cell; autoimmune encephalomyelitis; biological signal transduction; cancer immunotherapy; chemokine receptor; disease/disorder; heavy metal Pb; heavy metal lead; helper T cell; immunogen; in vivo; insular sclerosis; interventional strategy; jagged-1; jagged1 protein; new approaches; notch; notch protein; notch receptors; novel; novel approaches; novel strategies; novel strategy; pathway; protein activation; receptor expression; response; self recognition (immune); social role; thymus derived lymphocyte; transplant; treatment effect",The Role of Notch Signaling in Experimental Autoimmune Encephalomyelitis (EAE),,59205,ZRG1,Special Emphasis Panel,,3,59918,
7759185,F32,NS,5,,01/15/2010,01/14/2011,,5F32NS061587-03,,NINDS:52154;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,PSYCHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"WHEELER, DANIEL ;",8973668;,5F32NS061587,01/15/2008,01/14/2011,"Address; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Anxiety Disorders; Area; Associative Learning; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biologic Products; Biological Agent; Biological Products; Brain; Cognitive; Computer Programs; Computer software; Conditioned Stimulus; Conditioning Therapy; Conditioning, Classical; Conditionings, Classical; Confocal Microscopy; Consumption; Cues; Drug abuse; Eating Disorders; Encephalon; Encephalons; Environment; Event; FISH Technic; FISH Technique; FISH analysis; FOS gene; Fluorescent in Situ Hybridization; Food; Food Aversion; Future; G0S7; Gene Expression; Genes, Immediate-Early; Goals; Gustation; Image; Immediate-Early Genes; In Situ Hybridization, Fluorescence; Investigators; Laboratory Study; Lead; Learning; Leg; Lesion; Life Style Modification; Measures; Mediating; Messenger RNA; Methods and Techniques; Methods, Other; Microscopy, Confocal; Nature; Nervous; Nervous System, Brain; Organism; Outcome; Pattern; Pavlovian conditioning; Pb element; Procedures; Process; Property; Property, LOINC Axis 2; Proteins; Protooncogene FOS; Proxy; Public Health; RNA, Messenger; Relative; Relative (related person); Research; Research Personnel; Researchers; Rewards; Role; Scientist; Sensory; Series; Software; Sorting - Cell Movement; Stimulus; Structure; Taste; Taste Perception; Techniques; Testing; Training; Work; abuse of drugs; abuses drugs; amygdaloid nuclear complex; aversive conditioning; behavior intervention; behavioral intervention; biopharmaceutical; biotherapeutic agent; c fos; c-fos Gene; c-fos Proto-Oncogenes; classical conditioning; computer program/software; experience; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; imaging; immunoreactivity; interest; living system; mRNA; neglect; neural; neural circuit; neural circuitry; neural patterning; public health medicine (field); relating to nervous system; research study; social role; sorting; theories; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Neural Substrates of Mediated Learning,,61587,ZRG1,Special Emphasis Panel,,3,52154,
7775019,F32,NS,5,,01/02/2010,01/01/2011,PA-07-107,5F32NS063535-02,,NINDS:57686;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,PHYSIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"QUINLAN, KATHARINA ANN;",9298260;,5F32NS063535,01/02/2009,01/01/2011,"0-6 weeks old; 2-Amino-6-trifluoromethoxybenzothiazole; 21+ years old; 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester; Acute; Adolescent; Adolescent Youth; Adult; Age; Alanine; Alanine, L-Isomer; Aminoacetic Acid; Back; Blood Coagulation Factor IV; Blood Pressure, High; Buffers; Ca++ element; Calcium; Cells; Cessation of life; Chronic; Coagulation Factor IV; Coloring Agents; Common Rat Strains; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dendrites; Development; Diagnosis; Disease; Disorder; Dorsum; Drugs; Dyes; Effectiveness; Electrodes; Employee Strikes; Erythrocuprein; Evaluation; Exposure to; FDA approved; Factor IV; Future; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glutamates; Glycine; Hemocuprein; Human, Adult; Hypertension; Idiopathic Parkinson Disease; Image; In Vitro; Infant, Newborn; Isradipine; L-Alanine; L-Glutamate; Leg; Lewy Body Parkinson Disease; Link; Mammals, Mice; Mammals, Rats; Mediating; Medication; Medulla Spinalis; Membrane Potentials; Methods; Mice; Motor Cell; Motor Neurons; Murine; Mus; Muscle; Muscle Tissue; Mutation; Napping; Neonatal; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Newborn Infant; Newborns; Pace Stimulators; Pacemakers; Palsy; Paralysed; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Plegia; Predisposition; Preparation; Primary Parkinsonism; Property; Property, LOINC Axis 2; Rat; Rattus; Reflex; Reflex action; Rest; Resting Potentials; Riluzole; Route; SOD; Slice; Spinal Cord; Stimulators, Electrical, Pace; Strikes; Strikes, Employee; Substantia Nigra; Substantia nigra structure; Superoxide Dismutase; Superoxide[{..}]superoxide oxidoreductase; Susceptibility; Synapses; Synaptic; Time; Transmembrane Potentials; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Wild Type Mouse; Work; adult human (21+); channel blockers; cytocuprein; disease/disorder; drug development; drug/agent; effective therapy; excitotoxicity; genome mutation; hyperpiesia; hyperpiesis; hypertensive disease; imaging; juvenile; juvenile human; motoneuron; mouse model; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; neuronal excitability; newborn human (0-6 weeks); paralysis; paralytic; patch clamp; postnatal; presynaptic; response",Synaptic and intrinsic exitability in motoneurons in a mouse model of ALS.,,63535,ZRG1,Special Emphasis Panel,,2,57686,
7755859,F32,NS,5,,01/04/2010,07/03/2010,,5F32NS064775-02,,NINDS:26077;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,PHYSIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"QUITON, RAIMI L;",7046757;,5F32NS064775,01/04/2009,07/03/2010,"Affect; Area; Behavior; Behavioral; Central Nervous System; Cerebral cortex; Clinical; Common Rat Strains; Data; Development; Disease; Disorder; Dysfunction; Electrodes, Implanted; Functional disorder; GABA Agonists; GABA Receptor Agonists; Head; Hyperalgesia; Hyperalgesic Sensations; Implanted Electrodes; Infusion; Infusion procedures; Lesion; Mammals, Rats; Mammals, Rodents; Measures; Mechanics; Medulla Spinalis; Metric; Modeling; Myelopathy, Traumatic; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Pain; Pain Disorder; Painful; Pathway interactions; Perception; Physiopathology; Posterior Nuclear Complex; Posterior Nuclear Complices; Posterior Thalamic Nuclear Group; Posterior Thalamic Nuclei; Rat; Rattus; Reporting; Resistance; Rodent; Rodent Model; Rodentia; Rodentias; Sensory; Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stimulus; Structure; Surgical; Surgical Interventions; Surgical Procedure; Testing; Thalamic Nuclei; Thalamic structure; Thalamus; Thermal Hyperalgesias; Time; awake; central pain syndrome; chronic pain; chronic painful condition; disease/disorder; effective therapy; extracellular; gamma-Aminobutyric Acid Agonists; hyperalgia; improved; neuronal; novel; pain behavior; pathophysiology; pathway; public health relevance; resistant; response; somatosensory; spontaneous pain; surgery; thalamic",Thalamocortical Abnormalities in Central Pain Syndrome,,64775,ZRG1,Special Emphasis Panel,,2,26077,
7786262,F32,NS,5,,03/01/2010,02/28/2011,,5F32NS064870-02,,NINDS:50474;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PROVIDENCE,UNITED STATES,BIOCHEMISTRY,01,001785542,US,RI,02912,BROWN UNIVERSITY,"MAGINNIS, MELISSA ;",9387907;,5F32NS064870,03/01/2009,02/29/2012,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5-hydroxytryptamine 5 receptor; 5HT; 5HT5 receptor; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Asparagine; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biology; Blood Coagulation Factor IV; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Coagulation Factor IV; Combining Site; Complex; Confocal Microscopy; Demyelinating Diseases; Demyelinating Disorders; Development; Diathesis; Disease; Disease susceptibility; Disorder; EC 2.7; Encephalitis, JC Polyomavirus; Enteramine; Epithelium; Factor IV; Gene Transcription; Genetic; Genetic Transcription; Glia; Glial Cells; Glycoproteins; Hippophaine; Human; Human Polyomavirus JC; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Individual; Infection; Intracellular Communication and Signaling; Invaded; Investigators; JC Polyomavirus Encephalopathy; JC Virus; Kidney; Kinases; Kolliker's reticulum; L-Asparagine; Leukoencephalopathy, Progressive Multifocal; Life; Link; Man (Taxonomy); Man, Modern; Measures; Mediating; Melissa; Metabolic Glycosylation; Microscopy, Confocal; Molecular; Molecular Interaction; Mutagenesis, Site-Directed; Mutate; N-Acetylneuraminic Acids; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; PDZ protein; Pathogenesis; Pathway interactions; Patients; Peptide Domain; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Phosphotransferases; Play; Polyomavirus hominis 2; Polyomavirus, JC; Population; Progressive Multifocal Leukoencephalopathy; Protein Domains; Protein Phosphorylation; Proteins; RNA Expression; Reactive Site; Receptor Cell; Receptor Protein; Receptor Signaling; Receptors, Virus; Research; Research Personnel; Researchers; Role; Serotonin; Sialic Acids; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Subcellular Process; Targeted DNA Modification; Targeted Modification; Tertiary Protein Structure; Testing; Transcription; Transcription, Genetic; Transphosphorylases; Tropism; Urinary System, Kidney; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Physiology; Viral Receptor; Virus; Virus Diseases; Virus Receptors; Viruses, General; base; biological signal transduction; combinatorial; disease/disorder; disease/disorder proneness/risk; experiment; experimental research; experimental study; extracellular; gene product; glycosylation; immunosuppressed patient; inhibitor; inhibitor/antagonist; insight; liability to disease; mutant; nerve cement; neuronal; novel; pathogen; pathway; protein function; public health relevance; receptor; receptor internalization; renal; research study; response; serotonin 5 receptor; social role; transcription factor; viral infection; virus infection",The Role of Viral Receptors in JCV Reactivation and Progression to PML in AIDS,,64870,ZRG1,Special Emphasis Panel,,2,50474,
7755398,G11,HD,5,,01/01/2010,12/31/2010,PAR-08-096,5G11HD060437-02,,NICHD:74843;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BROWNSVILLE,UNITED STATES,MISCELLANEOUS,27,800187965,US,TX,78520,UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL,"COLOM, LUIS VICENTE (contact);MARTIN, JOSE GINORIS;",1877318 (contact);8013919;,5G11HD060437,01/15/2009,12/31/2013,"Address; Administrator; Ammon Horn; Area; Award; Back; Behavioral Research; Biomedical Research; Brain; Climate; Communication; Communities; Cornu Ammonis; Development; Development and Research; Diagnosis; Doctor of Medicine; Doctor of Philosophy; Dorsum; Drops; EXTMR; Educational workshop; Encephalon; Encephalons; Environment; Expenditure; Extramural; Extramural Activities; Faculty; Funding; Funding Mechanisms; Generalized Growth; Goals; Grant; Grant Review; Growth; Hippocampus; Hippocampus (Brain); Hispanic Populations; Hispanics; Hispanics or Latinos; Infrastructure; Institution; Investigators; Latino Population; M.D.; Measures; Meteorological Climate; Minority; Minority-Serving Institution; Modeling; Monitor; Nervous System, Brain; Newsletter; Ph.D.; PhD; Prevention; Productivity; Programs (PT); Programs [Publication Type]; Public Health; Publications; Qualifying; R & D; R&D; R01 Mechanism; R01 Program; RPG; Reliance; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Support; Researchers; Resources; Scientific Publication; Scientist; Self-Help Groups; Series; South Texas; Spanish Origin; Stream; Structure; Support Groups; Texas; Time; Tissue Growth; Training; Training Support; Universities; Workshop; Writing; climatic; college; conference; design; designing; hippocampal; hispanic community; human disease; improved; ontogeny; outreach; programs; public health medicine (field); public health relevance; research and development; self help organization; symposium",Extramural Associates Research Development Award at the University of Texas at Br," Relevance to Public Health The overarching goal of this EARDA proposal is to strengthen the institutional research culture (administrative and scientific) in order to expand the research capacity (with a special emphasis on building research programs related to the causes, diagnosis, prevention, and cure of human diseases) at this Hispanic-serving institution. Through this program we will build a bridge between the research administration and the scientific community through a focused approach on improving: (1) research administration and (2) scientific environment at UTB/TSC. Since UTB/TSC comprises the strongest group of scientists performing biomedical research south of San Antonio, improving the research administration and scientific environment will enhance the biomedical research capabilities at UTB/TSC and thus deeply impacting South Texas public health.",60437,ZHD1,Special Emphasis Panel,,2,74843,
7754102,H23,IP,5,,01/01/2010,12/31/2010,IP-03-006,5H23IP122525-08,,NCIRD:;,2010,NATIONAL CENTER FOR IMMUNICATION AND RESPIRATORY DISEASES,,HARTFORD,UNITED STATES,,01,807853791,US,CT,061061367,CONNECTICUT STATE DEPT OF PUBLIC HEALTH,"SACCO, VINCENT A;",10487904;,5H23IP122525,01/01/2008,12/31/2012,,IMMUNIZATION AND VACCINES FOR CHILDREN GRANTS,,122525,ZIP1,Special Emphasis Panel,,8,3944789,
7754096,H23,IP,5,,01/01/2010,12/31/2010,IP-03-006,5H23IP422521-09,,NCIRD:;,2010,NATIONAL CENTER FOR IMMUNICATION AND RESPIRATORY DISEASES,,ATLANTA,UNITED STATES,,05,142661680,US,GA,30303,GEORGIA DEPARTMENT OF COMMUNITY HEALTH,"CONNER, MICHELLE ;",9146272;,5H23IP422521,08/20/2009,12/31/2012,,IMMUNIZATION AND VACCINES FOR CHILDREN GRANTS,,422521,ZIP1,Special Emphasis Panel,,9,8102357,
7754109,H23,IP,5,,01/01/2010,12/31/2010,IP-03-006,5H23IP422554-08,,NCIRD:;,2010,NATIONAL CENTER FOR IMMUNICATION AND RESPIRATORY DISEASES,,RALEIGH,UNITED STATES,,04,,US,NC,27603,"NORTH CAROLINA ST DEPT/ENVIRON, HLTH, NR","ROWE-WEST, BETH ;",9146396;,5H23IP422554,01/01/2008,12/31/2012,,IMMUNIZATION AND VACCINES FOR CHILDREN GRANTS,,422554,ZIP1,Special Emphasis Panel,,8,7635270,
7764630,K01,AA,5,,02/01/2010,01/31/2011,PA-00-019,5K01AA015577-05,,NIAAA:113179;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"MCVICKER, BENITA ;",8029165;,5K01AA015577,02/01/2006,01/31/2011,"APO-1; APO-1 Antigen; APO-1 Cell Surface Antigen; Absolute ethanol; Activation Analysis; Alcohol, Ethyl; Alcohols; Analyses, Activation; Apoptosis; Apoptosis Antigen 1; Apoptosis Pathway; Apoptotic; Architecture; Area; Assay; B blood cells; B-Cells; B-Lymphocytes; Bile Canaliculi; Bioassay; Biologic Assays; Biological Assay; Biological Models; Biometals; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD95; CD95 Antigens; CD95 molecule; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell membrane; Cell model; Cell physiology; Cell surface; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Cellular model; Cessation of life; Characteristics; Chemical Class, Alcohol; Consultations; Cytofluorometry, Flow; Cytoplasmic Membrane; Death; District of Columbia; Doctor of Philosophy; Dose; ETOH; Engineering / Architecture; Ethanol; Evaluation; Event; FASTM; Fibroblasts; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Future; Gene Expression; Generations; Goals; Grain Alcohol; Grant; HCC; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Hybrid Cells; Instruction; Intracellular Communication and Signaling; Knowledge; Laboratories; Lead; Ligands; Liver; Liver Cells; Location; Mediating; Medical center; Membrane; Mentors; Methods; Methods and Techniques; Methods, Other; Methylcarbinol; Microfluorometry, Flow; Microinjections; Model System; Modeling; Models, Biologic; Nebraska; Pathway interactions; Pb element; Ph.D.; PhD; Phenotype; Phosphorylation; Plasma Membrane; Play; Primary carcinoma of the liver cells; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Trafficking; Proteins; Receptor Protein; Receptor Signaling; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Somatic Cell Hybrids; Structure of bile canaliculus; Study models; Subcellular Process; System; System, LOINC Axis 4; TNFRSF6; TNFRSF6 Receptor; TNFRSF6 gene; Techniques; Time; Trace Elements; Trace Mineral; Traffickings, Protein; Training; Training Support; Tumor Necrosis Factor Receptor Superfamily, Member 6; Universities; VESCL; Vesicle; Washington, D.C.; Washington, DC; Work; Zinc; Zn element; alcohol abuse therapy; alcohol abuse treatment; alcohol effect; alcohol treatment; alcoholism treatment; bile canaliculus structure; biological signal transduction; body system, hepatic; cell damage; cell injury; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; cultured cell line; design; designing; ethanol effect; experience; experiment; experimental research; experimental study; fas Antigens; fas Receptors; flow cytophotometry; functional mimics; gene product; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; interest; liver function; membrane structure; necrocytosis; organ system, hepatic; pathway; plasmalemma; protein transport; receptor; research study; social role; tool; trafficking",Alcohol & FAS-Mediated Apoptosis in Polarized Liver Cell,,15577,ZAA1,Special Emphasis Panel,,5,113179,
7771736,K01,AA,5,,02/01/2010,01/31/2011,PA-06-001,5K01AA017480-02,,NIAAA:152836;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,GAINESVILLE,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"MALDONADO-MOLINA, MILDRED M;",2099447;,5K01AA017480,02/15/2009,01/31/2013,"21 year old; 21+ years old; AODR death rate; AODR mortality; Address; Adolescent; Adolescent Youth; Adult; Advertisements; Age; Age Group Unspecified; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drug Related death rate; Alcohol or Other Drug Related mortality; Alcohols; American; Attenuated; Award; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cause of Death; Cessation of life; Chemical Class, Alcohol; Chicago; Cigarette; Communities; Complex; Crime; Data; Data Files; Death; Development; Drugs; Drugs, Illicit; Educational workshop; Environment; Environmental Factor; Environmental Risk Factor; EtOH drinking; Ethnic Origin; Ethnicity; Ethnicity aspects; Files, Data; Friends; Funding; Gender; Goals; Health; Heavy Drinking; Heterogeneity; Homicide; Human, Adult; Illicit Drugs; Investigators; K-Awards; K-Series Research Career Programs; K01 Award; K01 Mechanism; K01 Program; Knowledge; Life; Marihuana; Measures; Medication; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIAAA; NIH; NIH RFA; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Institutes of Health (U.S.); Parents; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Population; Prevalence; Prevention; Prevention Research; Preventive Intervention; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RPG; Randomized Controlled Trials; Request for Applications; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Research Scientist Development Award; Researchers; SUBGP; Series; Shapes; Social Problems; Source; Statistical Methods; Structure; Subgroup; Suicide; Sum; Teen; Teenagers; Teens; Testing; Time; Training; United States; United States National Institutes of Health; Work; Workshop; Youth; Youth 10-21; adult human (21+); age group; alcohol epidemiology; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol prevention; alcohol product use; alcohol related consequences; alcohol related mortality; alcohol use; alcoholic beverage consumption; alcoholic drink intake; career development; cost; deter alcohol use; disability; disease risk; disorder risk; drink heavily; drinking; drinking behavior; driving under influence; drug/agent; environmental risk; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experience; exposed to alcohol; exposure to alcohol; extreme drinking; fatal attempt; fatal suicide; health disparities; health disparity; heavy alcohol use; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; high school; improved; innovate; innovation; innovative; intent to die; juvenile; juvenile human; population health; preventional intervention strategy; programs; public health medicine (field); public health relevance; public policy on alcohol; randomized controlled study; risky sexual behavior; skills; social disturbance; suicidality; teen years; theories; trafficking; twenty-one year old",Alcohol Contextual Influences: Effects on Health Disparities and Mortality,,17480,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,152836,
7758249,K01,AI,5,,02/01/2010,01/31/2011,PA-06-001,5K01AI071015-03,,NIAID:131420;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"FURUNO, JON P;",7896731;,5K01AI071015,02/15/2008,01/31/2013,"Acute; Address; Admission; Admission activity; Aged 65 and Over; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial resistant; Caring; Communicable Diseases; Data; Data Base (PT); Database (PT); Database [Publication Type]; Development; Disasters; Effectiveness; Elderly; Elderly, over 65; Epidemiologist; Epidemiology; Geriatrics; Gerontology / Geriatrics; Goals; HOSP; Health system; Hospitals; Human; Human, General; Incidence; Infection; Infection Control; Infection prevention; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intervention; Intervention Strategies; Life; Literature; Long-Term Care; MRSA; Man (Taxonomy); Man, Modern; Math Models; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Microbiology; Miscellaneous Antibiotic; Mission; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Movement; NIAID; National Institute of Allergy and Infectious Disease; Outcome; Patient Transfer; Patients; Population; Prevalence; Prevalence Study; Prevent infection; Public Health; Published Database; Relative; Relative (related person); Research; Research Resources; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resources; Risk; Science of Microbiology; Secondary to; Study, Prevalence; Testing; Training; Transmission; advanced age; aged; antibiotic resistant; bacterial resistance; body movement; career; cohort; computerized; cost; cost effectiveness; design; designing; elders; extended care; geriatric; geriatric medicine; high risk; interventional strategy; late life; later life; mathematical model; mathematical modeling; methicillin resistant Staphylococcus aureus (organism); older adult; older person; overgrowth bacterial; pathogen; prevent; preventing; prospective; public health medicine (field); resistance to Bacteria; resistance to Bacterial; resistant to Bacteria; resistant to Bacterial; senior citizen; transmission process",Epidemiology of resistant bacteria in acute-care and long-term care facilities,,71015,MID,Microbiology and Infectious Diseases Research Committee,,3,131420,
7753897,K01,AR,5,,01/01/2010,12/31/2010,PA-00-019,5K01AR052352-05,,NIAMS:128401;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,CHARLOTTESVILLE,UNITED STATES,BIOMEDICAL ENGINEERING,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"BOTCHWEY, EDWARD A;",2112118;,5K01AR052352,03/05/2006,12/31/2010,"3-D; 3-Dimensional; Address; Binding; Binding (Molecular Function); Biocompatible Materials; Biology; Biomaterials; Biomedical Engineering; Bioreactors; Blood Vessels; Body Tissues; Bone; Bone Formation; Bone Marrow Stem Cell; Bone Tissue; Bone Transplantation; Bone and Bones; Bone remodeling; Bones and Bone Tissue; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cells; Co-culture; Cocultivation; Coculture; Coculture Techniques; Common Rat Strains; Complex; Computer Simulation; Computerized Models; Computing Methodologies; Deposit; Deposition; Development; Development Plans; Diffusion; Endothelial Cells; Engineering; Engineerings; Environment; Gene Expression; Generalized Growth; Goals; Grafting, Bone; Growth; Implant; In Vitro; Intracellular Communication and Signaling; Investigators; K01 Award; K01 Mechanism; K01 Program; Laboratories; Laboratory Research; Learning; Mammals, Rats; Mathematical Model Simulation; Mathematical Models and Simulations; Mechanics; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Methods; Microbeads; Microspheres; Models, Computer; Molecular Interaction; Morphogenesis; Nutrient; Organ System, Cardiovascular; Organism; Organogenesis; Orthopedic; Orthopedic Surgery procedures; Orthopedic Surgical Profession; Orthopedics; Osteoblasts; Osteogenesis; Osteoid; Perfusion; Physiology; Plans, Development; Programs (PT); Programs [Publication Type]; Rat; Rattus; Reporting; Research; Research Personnel; Research Resources; Research Scientist Development Award; Research Training; Research, Laboratory; Researchers; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Spatial Distribution; Surgery, Orthopedic; Technology; Time; Tissue Engineering; Tissue Growth; Tissues; Training; Universities; Vascular Endothelial Cell; Vascular remodeling; Vascular, Heart; Vascularization; Virginia; Work; angiogenesis; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; bone; bone healing; bone remodelling; career; career development; circulatory system; computational methodology; computational methods; computational modeling; computational models; computational simulation; computer based models; computer methods; computerized modeling; computerized simulation; design; designing; engineered tissue; experience; implantation; improved; in silico; in vivo; in vivo Model; innovate; innovation; innovative; insight; interest; laurencin; living system; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; ontogeny; osteoprogenitor cell; pre-clinical; preclinical; professor; programs; repair; repaired; scaffold; scaffolding; skills; social role; therapeutic effectiveness; vascular; virtual simulation",Vascularized Bone Grafts for Tissue Engineering,,52352,AMS,Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee,,5,128401,
7761683,K01,AR,5,,12/01/2009,11/30/2010,PA-06-001,5K01AR056734-02,,NIAMS:118800;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN FRANCISCO,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"KAZAKIA, GALATEIA J;",8310911;,5K01AR056734,02/01/2009,11/30/2013,"Age; Applications Grants; BMI percentile; BMI z-score; Biomechanics; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Body mass index; Bone; Bone and Bones; Bones and Bone Tissue; California; Causality; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Control Groups; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; DXA; Data; Development; Disease Frequency Surveys; Distal; Doctor of Medicine; Doctor of Philosophy; Dual-Energy X-Ray Absorptiometry; Etiology; Forearm Fracture; Fracture; Goals; Grant Proposals; Grants, Applications; Image; Imaging Procedures; Imaging Techniques; Incidence; K01 Award; K01 Mechanism; K01 Program; M.D.; Measures; Medical center; Medicine; Mentored Research Scientist Development Award; Mentored Training Award; Mentors; Methods and Techniques; Methods, Other; Metric; Modeling; Morphology; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Osteoporosis; Patients; Peripheral; Ph.D.; PhD; Population; Porosity; Post-Menopause; Post-menopausal Period; Postdoc; Postdoctoral Fellow; Postmenopausal Period; Postmenopause; Process; Quetelet index; Radial; Radiology; Radiology Specialty; Radiology, General; Recruitment Activity; Reporting; Research; Research Associate; Research Scientist Development Award; Resolution; Rheumatology; Risk Assessment; San Francisco; Science of Medicine; Site; Skeleton; Staging; Statistical Methods; Structure; Technics, Imaging; Techniques; Training; Universities; Woman; X-Ray Absorptiometry, Dual-Energy; base; bone; bone fracture; bone quality; career; clinical investigation; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experience; human subject; image processing; imaging; imaging modality; in vivo; musculoskeletal disorder; post-doc; post-doctoral; post-menopausal; postmenopausal; professor; prospective; recruit; skeletal; statistics/biometry; tool",In vivo imaging of cortical porosity in the peripheral skeleton,,56734,AMS,Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee,,2,118800,
7759632,K01,AT,5,,02/01/2010,01/31/2011,PA-06-001,5K01AT004108-04,,NCCAM:126711;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,MORGANTOWN,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,191510239,US,WV,265066845,WEST VIRGINIA UNIVERSITY,"INNES, KAREN  KIM E;",6851971;,5K01AT004108,02/01/2008,01/31/2013,"Applications Grants; Area; Award; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Medicine; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biology; Cardiovascular Diseases; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cause of Death; Change of Life, Female; Chronic; Chronic Disease; Chronic Illness; Clinical; Comorbidity; Conditioning Therapy; Coupled; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Discipline; Disease; Disorder; Educational workshop; Epidemiologist; Fellowship; Female Health; Goals; Grant Proposals; Grants, Applications; Health Care Costs; Health Costs; Healthcare Costs; Insulin Resistance; Intervention; Intervention Strategies; Intervention Studies; Investigators; K-Awards; K-Series Research Career Programs; Lead; Life Style Modification; MODY; Maturity-Onset Diabetes Mellitus; Menopause; Metabolic; Methods; Mind-Body Intervention; Mind-Body Medicine; Mind-Body Medicine (with OBSSR); NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Over weight; Overweight; Pb element; Physiology; Pilot Projects; Population; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Prevention; Prevention Measures; Productivity; Programs (PT); Programs [Publication Type]; Prophylactic treatment; Prophylaxis; Randomized; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Training; Researchers; Risk Factors; Risk Reduction; Solid; Stress; Syndrome; T2D; T2DM; Therapeutic Intervention; Training; Training Programs; Type 2 diabetes; Type II diabetes; Woman; Women's Health; Workshop; Yoga; adult onset diabetes; base; behavior intervention; behavioral intervention; body-mind; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; chronic disease/disorder; chronic disorder; cost effective; design; designing; diabetic; disease/disorder; experience; heavy metal Pb; heavy metal lead; indexing; insulin resistant; insulin sensitivity; intervention therapy; interventional strategy; ketosis resistant diabetes; maturity onset diabetes; meetings; menopausal; mind body approach; mind body medicine skills; mind body method; mind body techniques; mind body therapy; mind body treatments; mind body wellness; non-diabetic; nondiabetic; older women; pilot study; post-menopausal; postmenopausal; programs; psychologic; psychological; randomisation; randomization; randomly assigned; sedentary; skills; skills training",Yoga and Cardiovascular Disease Risk in Older Women,,4108,ZAT1,Special Emphasis Panel,,4,126711,
7794894,K01,DA,5,,04/01/2010,03/31/2011,PA-06-001,5K01DA022298-03,,NIDA:146305;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"JENNINGS, JACKY M;",8549472;,5K01DA022298,04/05/2008,03/31/2013,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adolescent; Adolescent Youth; Affect; Alcohol Drinking; Alcohol consumption; Behavioral Research; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Censuses; Data; Data Set; Data Sources; Dataset; Development; Discipline; Drug abuse; Drugs; Environment; Epidemiology; Equation; EtOH drinking; Generations; Gonococcal Infection; Gonorrhea; HIV; HIV Prevention; HIV/AIDS prevention; HIV/STD; HTLV-III; Household; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Instruction; Interdisciplinary Research; Interdisciplinary Study; K-Awards; K-Series Research Career Programs; Knowledge; LAV-HTLV-III; Lead; Lymphadenopathy-Associated Virus; Marketing; Measures; Medication; Mentors; Modeling; Multidisciplinary Collaboration; Multidisciplinary Research; Neighborhoods; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Police; Policies; Population Surveillance; Prevention program; Property; Property, LOINC Axis 2; Psychometric; Psychometrics; Public Health Surveillance; Public Housing; Race; Racial Group; Reading; Research; Research Career Program; Research Career Programs, K-Series; Risk; Role; Science of Statistics; Scientist; Site; Social Development; Social Environment; Socio-economic status; Socioeconomic Status; Sources, Data; Statistics; Status, Socioeconomic; Stocks, Racial; Study, Interdisciplinary; Training; Training Activity; Virus-HIV; Youth; Youth 10-21; abuse of drugs; abuses drugs; adult youth; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; cohesion; design; designing; drug market; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; heavy metal Pb; heavy metal lead; juvenile; juvenile human; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; pathway; psychologic; psychological; responsible research conduct; sex; skills; social; social climate; social context; social role; socioenvironment; statistics; surveillance data; theories; young adult",Drug Affected Urban Environments and STIS Among Youth,,22298,NIDA,Neuropharmacology Research Subcommittee,,3,146305,
7753871,K01,DK,5,,01/01/2010,12/31/2010,PAR-05-066,5K01DK078513-03,,NIDDK:119461;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"KOHLER, JAMES J;",1957605;,5K01DK078513,03/15/2008,12/31/2010,"1-(2'fluoro-2'-deoxyarabinofuranosyl)-5-iodouracil; 1-(2-deoxy-2-fluoro-beta-arabinofuranosyl)-5-iodouracil; 2'-fluoro-5-iodoarauracil; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-PMPA; AIDS; ATP biosynthesis (oxidative); AZT; AZT (Antiviral); Ablation; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adverse effects; Anions; Anti-Retroviral Agents; Antiretroviral Agents; Award; Azidothymidine; Biogenesis; Biological; Blotting, Western; Body Tissues; CCL21; CCL21 gene; CKb9; Cadherins; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cells; Chronic Kidney Failure; Chronic Renal Disease; Clinical; Complex; Cristobalite; DISSEC; DNA, Mitochondrial; Disease; Disorder; Dissection; Doctor of Philosophy; Dose; Drug Combinations; Drug Kinetics; Dysfunction; Electromagnetic, Laser; Electron Transport; Environment; Epithelial; Epithelial Cells; Epithelium; Evaluation; Event; FIAU; Family; Fellowship Program; Functional disorder; Gender; Glomerular disease; Human; Human, General; Immunologic Deficiency Syndrome, Acquired; Infection; Injury; Investigators; K-Awards; K-Series Research Career Programs; Kidney; Kidney Diseases; Kidney Failure; Kidney Failure, Chronic; Kidney Insufficiency; Kidney Tubules; Kidney Tubules, Proximal; Knock-out; Knockout; Knockout Mice; Lasers; Liver Cell Adhesion Molecules; MGC34555; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane Transport Proteins, Organic Anion; Mentors; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microscopic; Mitochondria; Mitochondrial DNA; Molecular; Murine; Mus; Nephropathy; Nucleosides; Nucleotides; Null Mouse; Organic Anion Transporters; Origin of Life; Outcome; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Pathogenesis; Pathology; Ph.D.; PhD; Pharmacokinetics; Phosphates; Phosphorylation; Physiopathology; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Protein Trafficking; Proteins; Proximal Kidney Tubules; Radiation, Laser; Renal Cell; Renal Disease; Renal Failure; Renal Failure, Chronic; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Renal tubule structure; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Reverse Transcriptase Inhibitors; SCYA21; SLC; Sampling; Sand; Schools, Medical; Series; Silica; Silicon Dioxide; Structure; TCA4; Tenofovir; Tenofovir disoproxil fumarate; Thymidine, 3'-azido-3'-deoxy-; Time; Tissues; Toxic effect; Toxicities; Traffickings, Protein; Training; Transgenic Mice; Transgenic Organisms; Treatment Period; Treatment Side Effects; Tridymite; Tubular; Tubular formation; Universities; Urinary System, Kidney; Virus; Viruses, General; Western Blotting; Western Blottings; Western Immunoblotting; Work; ZDV; Zidovudine; anti-retroviral; antiretroviral; antiretroviral therapy; azidodeoxythymidine; base; chronic kidney disease; disease/disorder; electron transfer; experience; experiment; experimental research; experimental study; fialuridine; gain of function; gene product; in vivo; inorganic phosphate; insight; kidney cell; kidney disorder; liver cell adhesion molecule; loss of function; medical schools; member; mitochondrial; mtDNA; nucleotide analog; pathogen; pathophysiology; polypeptide; programs; protein blotting; protein transport; renal; renal disorder; renal proximal tubule; renal tubular transport; renal tubule; replicase; research study; side effect; standard of care; therapy adverse effect; tool; transgenic; treatment adverse effect; treatment days; treatment duration",Mechanisms of Tenofovir Renal Tubular Toxicity,,78513,ZDK1,Special Emphasis Panel,,3,119461,
7746458,K01,DK,5,,02/01/2010,01/31/2011,PA-06-001,5K01DK080241-03,,NIDDK:135275;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"NAHMIAS, YAAKOV ;",8890293;,5K01DK080241,03/01/2008,01/31/2013,"Advisory Committees; Animals; Arts; Award; Biomedical Engineering; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cell Communication and Signaling; Cell Count; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Number; Cell Signaling; CellLine; Cells; Chemotherapy-Hormones/Steroids; Clinical; Collagen; Complex; Development; Development Plans; Developmental Biology; ES Cell Line; ES cell; Elements; Embryonic Stem Cell Line; Endocrine Gland Secretion; Endoderm; Endoderm Cell; Endodermal Cell; Environment; Event; GFAC; GFP; Gastrointestinal Tract, Pancreas; Gel; Gene Expression; General Hospitals; Genes; Genes, Reporter; Genetic; Goals; Green Fluorescent Proteins; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hepatic; Hepatic Cells; Hepatic Failure; Hepatic Parenchymal Cell; Hepatocyte; Hormones; Hospitals, General; Human; Human, General; In Vitro; Inflammatory Response; Institutes; Intracellular Communication and Signaling; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; Lectures; Lectures (PT); Lectures [Publication Type]; Life; Liver; Liver Cells; Liver Failure; Mammals, Mice; Man (Taxonomy); Man, Modern; Massachusetts; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Microfabrication; Microfluidic; Microfluidics; Molecular; Monitor; Mother Cells; Murine; Mus; Network-based; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pancreas; Pancreatic; Pancreatic beta Cell; Pathway interactions; Phenotype; Plans, Development; Population; Progenitor Cells; Proliferating; Publishing; Regenerative Medicine; Reporter Genes; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Resources; Researchers; Resources; Schools, Medical; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stem cells; Structure of beta Cell of islet; Surgical; Surgical Interventions; Surgical Procedure; Task Forces; Techniques; Therapeutic Hormone; Training; Work; bioengineering; bioengineering/biomedical engineering; biological signal transduction; body system, hepatic; career development; clinical applicability; clinical application; cultured cell line; cytokine; embryonic stem cell; insight; instructor; internal control; lectures; medical schools; novel; organ system, hepatic; pancreas beta cell; pathway; self-renewal; square foot; stem cell differentiation; stem cell of embryonic origin; surgery; tool; transcription factor",Gene Network Based Differentiation of Stem Cells in a Microfabricated Array,,80241,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,3,135275,
7755830,K01,DK,5,,02/01/2010,01/31/2011,PA-06-001,5K01DK082725-02,,NIDDK:127116;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,PATHOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"DEPAOLO, R. WILLIAM ;",8104188;,5K01DK082725,02/01/2009,01/31/2014,"APC; ATGN; Antigen-Presenting Cells; Antigens; Biological Models; Blood Coagulation Factor IV; Body Tissues; Breeding; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Ca++ element; Calcium; Cells; Cells, CD4; Coagulation Factor IV; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Extracellular Signal-Regulated Kinase Gene; Factor IV; Gastroenteritis; Gastrointestinal Tract, Small Intestine; Generations; Goals; IL-10; IL10; IL10A; INFLM; Immune; Immunologic Accessory Cells; In Vitro; Infection; Inflammation; Ingestion; Interleukin 10 Precursor; Interleukin-10; Intestinal; Intestinal Mucosa; Intestines; Intestines, Small; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; Knockout Mice; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; Mammals, Mice; Mediating; Mesenteric Lymphadenitis; Mice; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinase Gene; Moab, Clinical Treatment; Model System; Models, Biologic; Molecular; Monoclonal Antibodies; Monocytes / Macrophages / APC; Mucosal Immune Responses; Murine; Mus; Null Mouse; Oral; PRKM8; PRKM9; Pasteurella pestis; Pathogenesis; Pathogenicity Factors; Peripheral; Peyer's Patches; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Reporter; Research; Role; SAPK1; Site; Small Intestines; Structure of aggregated lymphoid follicle of small intestine; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; TLR6; TLR6 gene; Thymus-Dependent Lymphocytes; Tissues; Transgenic Organisms; Tropism; Virulence Factors; Y. enterocolitica; Y. pestis; Y.enterocolitica; Y.pestis; Yersinia; Yersinia enterocolitica; Yersinia pestis; accessory cell; bacterial immunostimulant; bacterial lysate; bowel; cytokine; helper T cell; immunogen; insight; mucosal site; mutant; p54aSAPK; programs; public health relevance; response; small bowel; social role; thymus derived lymphocyte; transgenic",Role of JNK2 and TLR6 during Y. enterocolitica induced mucosal immune responses,,82725,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,2,127116,
7760555,K01,EB,5,,02/01/2010,01/31/2011,PA-06-001,5K01EB006061-04,,NIBIB:157401;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,MAYWOOD,UNITED STATES,PHYSIOLOGY,04,791277940,US,IL,60153,LOYOLA UNIVERSITY CHICAGO,"ROBIA, SETH L;",7621456;,5K01EB006061,02/01/2007,01/31/2012,"Affect; Binding; Binding (Molecular Function); Biological Function; Biological Process; Biomedical Engineering; Biomimetics; Blood Coagulation Factor IV; Ca++ element; Calcium; Chemicals; Clinical; Coagulation Factor IV; Complex; Complexes, Macromolecular; Cristobalite; Development; Devices; Disease; Disorder; Dissociation; Drugs; Endoplasmic Reticulum; Engineering; Engineerings; Ergastoplasm; FRET; Factor IV; Fluorescence Resonance Energy Transfer; Goals; Heart failure; Hybrids; In Vitro; Investigation; Ion Pumps; Kinetic; Kinetics; Ligands; Macromolecular Complexes; Measures; Medication; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Mimetics, Biological; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Preparation; Process; Protein Dynamics; Proteins; Proteolipids; Public Health; Pump; Pus; R01 Mechanism; R01 Program; RPG; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rupture; Sand; Scientist; Silica; Silicon Dioxide; Surface; Surface Proteins; Techniques; Testing; Training; Tridymite; Work; bioengineering; bioengineering/biomedical engineering; cardiac failure; career; conformation; conformational state; disease/disorder; drug/agent; experiment; experimental research; experimental study; gene product; in vivo; interest; membrane structure; new technology; novel; particle; phospholamban; protein complex; protein function; public health medicine (field); research study; silica gel; silochrome; tool",Novel Physical Methods for Determining Membrane Protein Dynamics and Kinetics,,6061,ZEB1,Special Emphasis Panel,,4,157401,
7760087,K01,MH,5,,02/01/2010,01/31/2011,PA-00-019,5K01MH076018-05,,NIMH:135897;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"HAHN, MAUREEN K;",6443092;,5K01MH076018,02/01/2006,01/31/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 3-(2-Aminoethyl)-1H-indol-5-ol; 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropylamine; 3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5HT; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ANS Diseases; Active Biological Transport; Active Transport; Aminalon; Aminalone; Amino Acids; Anabolism; Antidepressant Drugs, Tricyclic; Antidepressants, Tricyclic; Antidepressive Agents, Tricyclic; Area; Attention; Autonomic Diseases; Autonomic Nervous System Diseases; Autonomic nervous system disorders; Award; Behavior; Behavioral; Behavioral Assay; Binding; Binding (Molecular Function); Biochemistry; Biologic Transport, Active; Biological Transport, Active; Biomedical Research; Butanoic acid, 4-amino-; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Catecholamines; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Chemistry, Biological; Chromosome 16; Chromosomes, Human, Pair 16; Clinical; Cocaine; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Confocal Microscopy; Core Facility; DAT; DAT dopamine transporter; Development; Development Plans; Disease; Disorder; Disturbance in cognition; Doctor of Philosophy; Educational process of instructing; Employee Strikes; Enteramine; Environment; Exons; Family; Fellowship; GABA; Gene variant; Generations; Genes; Genetic; Genetic Diversity; Genetic Variation; Hippophaine; Human; Human, General; Immunofluorescence Microscopy; Impaired cognition; In Vitro; Intermediary Metabolism; Intervening Sequences; Intracellular Communication and Signaling; Introns; Investigators; Knock-in; Knock-in Mouse; Knock-out; Knockout; Laboratories; Learning; Levarterenol; Levonorepinephrine; Link; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mentors; Metabolic Processes; Metabolism; Methylphenidate; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Immunofluorescence; Molecular Interaction; Moods; Murine; Mus; N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine; NET protein, neuronal; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Noradrenaline; Norepinephrine; Organ System, Cardiovascular; Performance; Peripheral; Ph.D.; PhD; Phenotype; Phorbol Esters; Physiology; Plans, Development; Play; Polymorphism, Single Base; Population; Postdoc; Postdoctoral Fellow; Preparation; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Publications; Regulation; Research; Research Associate; Research Personnel; Researchers; Role; SNP; SNPs; SNS; Scientific Publication; Scientist; Serotonin; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Strikes; Strikes, Employee; Sympathetic Nervous System; Sympathins; Synapses; Synaptic; System; System, LOINC Axis 4; Teaching; Technology; Training; Transgenic Mice; Tricyclic Antidepressive Agents; Universities; Uphill Transport; Variant; Variation; Variation (Genetics); Vascular, Heart; allelic variant; aminoacid; autonomic disorder; biological signal transduction; biosynthesis; cardiovascular function; career; career development; circulatory system; cognitive dysfunction; cognitive loss; cognitively impaired; conference; design; designing; disease risk; disease/disorder; disorder risk; dopamine transporter; dopamine transporter proteins; gamma-Aminobutyric Acid; genetic variant; inhibitor; inhibitor/antagonist; instructor; member; mouse model; neurobehavioral; neuronal; neuropsychiatric; neuropsychiatry; nisoxetine; noradrenaline transporter; noradrenergic; norepinephrine transporter; norepinephrine transporter protein; novel; post-doc; post-doctoral; presynaptic; programs; psychostimulant; response; reuptake; slc6a2 protein; slc6a5 protein; social role; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5; success; symposium; trafficking; trait; transgene expression; vector; working memory",Neurobehavioral Analysis of Norepinephrine Transporter Variants,,76018,NMB,Neurobiology of Motivated Behavior Study Section,,5,135897,
7758253,K01,NS,5,,02/01/2010,01/31/2011,PAR-02-106,5K01NS054096-05,,NINDS:179766;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ANDERSON, ANA C;",1945464;,5K01NS054096,02/03/2006,01/31/2011,"ATGN; Affect; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Antigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; CNS autoimmunity; Complement; Complement Proteins; Congenic Strain; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diathesis; Disease; Disease susceptibility; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; GWAS; Genes; Genetic; Human; Human, General; IDD; IDDM; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inbred NOD Mice; Inbred Strains Mice; Insulin-Dependent Diabetes Mellitus; Knowledge; Man (Taxonomy); Man, Modern; Mice, Inbred NOD; Mice, Inbred Strains; Mice, Transgenic; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Mouse Strains; Mouse, NOD; Myelin; Myeloencephalitis; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Predisposition; Production; RNA Splicing; Research Resources; Resistance; Resources; Self Tolerance; Sensitization, Immunologic; Sensitization, Immunological; Splicing; Susceptibility; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Testing; Thymus-Dependent Lymphocytes; Transgenic Mice; Transgenic Organisms; Twin Studies; Type 1 diabetes; Variant; Variation; autoimmune disorder; autoimmune encephalomyelitis; autoreactive T cell; central nervous system autoimmunity; congenic; cytokine; diabetes; disease/disorder; disease/disorder proneness/risk; genetic element; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; immunogen; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; liability to disease; model organism; resistant; resistant strain; thymus derived lymphocyte; tool; transgenic; type I diabetes; whole genome association studies; whole genome association study",Genetic Elements that Influence Susceptibility to CNS Autoimmunity,,54096,NST,Training Grant and Career Development Review Committee,,5,179766,
7760558,K01,NS,5,,02/01/2010,01/31/2011,PAR-05-071,5K01NS057409-04,,NINDS:149302;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AMHERST,UNITED STATES,BIOLOGY,01,153926712,US,MA,010039242,UNIVERSITY OF MASSACHUSETTS AMHERST,"DOWNES, GERALD BRIAN;",1876282;,5K01NS057409,02/01/2007,01/31/2012,"Award; Behavior; Biological Neural Networks; Biology; Blood Coagulation Factor IV; Brachydanio rerio; Ca++ element; Calcium; Candidate Disease Gene; Candidate Gene; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Coagulation Factor IV; Complement; Complement Proteins; DNA Molecular Biology; Danio rerio; Defect; Development; Doctor of Philosophy; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Event; Exhibits; Factor IV; Funding; Gene Expression; Genes; Genetic; Genetic analyses; Goals; Human; Human, General; Image; Injection of therapeutic agent; Injections; K-Awards; K-Series Research Career Programs; Life; Man (Taxonomy); Man, Modern; Maps; Massachusetts; Medulla Spinalis; Meiosis; Mentors; Methods and Techniques; Methods, Other; Microscopic; Molecular; Molecular Biology; Motor Cell; Motor Neurons; Movement; Muscle; Muscle Cell Contraction; Muscle Cells; Muscle Cells, Mature; Muscle Contraction; Muscle Tissue; Muscle function; Muscular Contraction; Mutate; Myocytes; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurosciences Research; Pattern; Ph.D.; PhD; Programs (PT); Programs [Publication Type]; RFP; Request for Proposals; Research; Research Career Program; Research Career Programs, K-Series; Speed; Speed (motion); Spinal Cord; Staging; Swimming; Taxes; Techniques; Testing; Touch; Touch sensation; Universities; Vertebrate Animals; Vertebrates; Walking; Zebra Danio; Zebra Fish; Zebrafish; base; body movement; career; cell imaging; cellular imaging; developmental neurobiology; experience; experiment; experimental research; experimental study; genetic analysis; imaging; in vivo; insight; kinematics; meiotic; member; motoneuron; mutant; neural network; neuronal; novel; professor; programs; research study; response; spinal cord imaging; tool; vertebrata",Genetic Analysis of Spinal Cord Network Formation in Zebrafish,,57409,NST,Training Grant and Career Development Review Committee,,4,149302,
7761257,K01,TW,5,,02/01/2010,01/31/2011,PAR-07-014,5K01TW007142-06,,FIC:124616;,2010,FOGARTY INTERNATIONAL CENTER,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"KOENIG, SERENA PATRICIA;",7951561;,5K01TW007142,09/01/2004,01/31/2012,"21+ years old; AIDS; AIDS Virus; AIDS, International; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adherence; Adherence (attribute); Adult; Affect; Analysis, Data; Arm; Benefits and Risks; CD4 Lymphocyte Count; CD4+ Cell Counts; CD4+ Counts; Cells; Clinical; Clinical Trials; Clinical Trials, Unspecified; Complex; Computer Simulation; Computerized Models; Consensus; Cost Effective Analyses; Cost Effectiveness Analysis; Cost Measures; Data; Data Analyses; Data Set; Dataset; Decision Modeling; Department of Health and Human Services; Department of Health and Human Services (U.S.); Disease; Disorder; Drug resistance; Drugs; Early treatment; Financial cost; Grant; Guidelines; HHS; HIV; HIV/AIDS; HIV/AIDS problem; HOSP; HTLV-III; Haiti; Hospitalization; Human Immunodeficiency Viruses; Human Resources; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Immunologic Deficiency Syndrome, Acquired; Infection; International; International AIDS; Journals; K01 Award; K01 Mechanism; K01 Program; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi?s Sarcoma; LAV-HTLV-III; Laboratories; Life; Life Expectancy; Lung TB; Lung Tuberculosis; Lymphadenopathy-Associated Virus; Magazine; Manpower; Manuscripts; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Measures, Cost; Medical; Medication; Mentored Research Scientist Development Award; Mentored Training Award; Method LOINC Axis 6; Methodology; Modeling; Modeling, Decision; Models, Computer; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Hemorrhagic Sarcoma; Opportunistic Infections; Outcome; Outcome Measure; Outcomes of Therapy; Patient Self-Report; Patients; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacies; Pharmacy facility; Pill; Policies; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Publications; Pulmonary TB; Pulmonary Tuberculosis; Questionnaires; Randomized; Randomized Clinical Trials; Research; Research Resources; Research Scientist Development Award; Resources; Scientific Publication; Self-Report; Simulation, Computer based; Societies; Staging; T4 Lymphocyte Count; Time; Toxic effect; Toxicities; Treatment Cost; Treatment Efficacy; Treatment outcome; Trials, Randomized Clinical; Tuberculosis; Tuberculosis, Pulmonary; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Upper arm; Virus-HIV; WHO; World Health Organization; adult human (21+); antiretroviral therapy; base; clinical investigation; cohort; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cost; cost effectiveness; cost efficient analysis; disease natural history; disease/disorder; disseminated TB; disseminated tuberculosis; drug resistant; drug/agent; in silico; life time cost; lifetime cost; medication adherence; medication compliance; natural history of disease; personnel; pill (pharmacologic); primary outcome; programs; public health medicine (field); randomisation; randomization; randomly assigned; resistance to Drug; resistant to Drug; skills; therapeutic efficacy; therapeutically effective; therapy adherence; therapy outcome; tuberculous spondyloarthropathy; virtual simulation",Cost-effectiveness of Early vs. Delayed Antiretroviral Therapy in Haiti,,7142,ZRG1,Special Emphasis Panel,,6,124616,
7759160,K02,AI,5,,02/01/2010,01/31/2011,PA-00-020,5K02AI073101-04,,NIAID:142020;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PULLMAN,UNITED STATES,VETERINARY SCIENCES,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"MEALEY, ROBERT H;",2190729;,5K02AI073101,02/15/2007,01/31/2012,"AIDS; AIDS Virus; Ab-mediated protection; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acute; Address; Alleles; Allelomorphs; Antibody-mediated protection; Antigenic Determinants; Appearance; Avidity; Award; B blood cells; B-Cells; B-Lymphocytes; Bacteriology; Binding Determinants; Biological Models; Blood Plasma; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; Capsid Proteins; Cells; Cessation of life; Characteristics; Chimera Protein; Chimeric Proteins; Clinical; Coat Proteins; Collaborations; Communicable Diseases; DNA Vaccines; Death; Defect; Development; Disease; Disorder; EIA virus; EIAV; EXTMR; Envelope Protein; Epitopes; Equine; Equine Infectious Anemia Virus; Equine Species; Equus caballus; Equus przewalskii; Extramural; Extramural Activities; Faculty; Funding; Fusion Protein; Gagging; Gene Products, env; Genes, Class I; Genes, MHC Class I; Goals; HIV-1; HIV-1 vaccine; HIV-I; HIV1; HIV1 vaccine; Haplotypes; Heterogeneity, Population; History; Horse, Domestic; Horses; Human; Human immunodeficiency virus 1; Human, General; Immune; Immunization; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunologic Stimulation; Immunological Stimulation; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Individual; Infection; Infectious Anemia Virus, Equine; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infusion; Infusion procedures; Investigators; Knowledge; Lentivirinae; Lentivirus; Lentivirus Infections; Lentivirus disease; Life; MHC Class I; MHC Class I Genes; Macaca mulatta; Man (Taxonomy); Man, Modern; Mediating; Medicine; Methods; Microbiology; Microbiology, Virology, Parasitology; Moab, Clinical Treatment; Model System; Models, Biologic; Monoclonal Antibodies; Naked DNA Vaccines; Parasites; Parasitology; Pathology; Patients; Phase; Plasma; Plasmids; Population; Population Heterogeneity; Pressure; Pressure- physical agent; Prevention Measures; Programs (PT); Programs [Publication Type]; Prophylactic treatment; Prophylaxis; Recording of previous events; Reflex, Pharyngeal; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; SHIV; SIV; Science of Medicine; Science of Microbiology; Science of Virology; Sensitization, Immunologic; Sensitization, Immunological; Serum, Plasma; Simian Immunodeficiency Viruses; Subfamily lentivirinae; Swamp Fever Virus; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T8 Cells; T8 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Time; Vaccine Design; Vaccine Production; Vaccines; Vaccines, DNA; Vaccines, Recombinant DNA; Vaccinia; Variant; Variation; Viral; Viral Burden; Viral Coat Proteins; Viral Load; Viral Load result; Viral Outer Coat Protein; Viremia; Virology; Virulent; Virus; Virus-Lenti; Viruses, General; career; disease/disorder; diverse populations; env Antigens; env Gene Products; env Polyproteins; env Protein; experiment; experimental research; experimental study; heterogeneous population; human T cell leukemia virus III; human T lymphotropic virus III; neutralizing antibody; pressure; programs; protective effect; reconstitute; reconstitution; research study; response; simian HIV; simian human immunodeficiency virus; skills; social role; thymus derived lymphocyte; vaccinia vector; vaccinia virus vector; viraemia; viral sepsis; virology; virusemia",Lentivirus Control by CTL and Neutralizing Antibody,,73101,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,4,142020,
7755868,K02,DA,5,,02/01/2010,01/31/2011,PA-06-527,5K02DA021304-03,,NIDA:127818;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SOFUOGLU, MEHMET ;",6194163;,5K02DA021304,02/01/2008,01/31/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Addiction, Cocaine; Adrenergic Agents; Adrenergic Drugs; Adrenergic alpha-Antagonists; Adrenergic alpha-Receptor Blockaders; Adrenergics; Affect; Aminalon; Aminalone; Area; Attenuated; Butanoic acid, 4-amino-; Cessation of smoking; Cigarette; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Cognitive; Coreg; Dependence, Nicotine; Dependence, Tobacco; Dependences, Cocaine; Development; Digit; Digit structure; Doctor of Medicine; Doctor of Philosophy; Dose; Drug Therapy; Drugs; Epilepsy; Epileptic Seizures; Epileptics; Female; Funding; GABA; GlaxoSmithKline brand of carvedilol; Goals; Gonadal Steroid Hormones; Human; Human, General; ISA; Independent Scientist Award; Intravenous; K02 Award; Laboratories; Laboratory Study; M.D.; Man (Taxonomy); Man, Modern; Measures; Medication; Menstrual cycle; Mentors; Method LOINC Axis 6; Methodology; Modeling; N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid; Neurobiology; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Out-patients; Outpatients; PBO; Patient Self-Report; Performance; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Pharmacotherapy; Placebos; Programs (PT); Programs [Publication Type]; Psychiatry; Psychostimulant dependence; Publications; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Questionnaires; Research; SCHED; Salaries; Schedule; Schools, Medical; Scientific Publication; Seizure Disorder; Self Administration; Self-Report; Severities; Sex Hormones; Sex Steroid Hormones; Sham Treatment; Smoker; Smoking; System; System, LOINC Axis 4; Testing; Tobacco; Tobacco Dependence; Tobacco smoking behavior; Training; Universities; Wages; Withdrawal; Withdrawal Symptom; Work; addiction; adrenergic; alpha antiadrenergic agent; alpha blocker; alpha-Adrenergic Blocking Agents; alpha-Blockers, Adrenergic; behavioral pharmacology; carvedilol; cease smoking; cigarette smoking; clinical investigation; craving; drug/agent; epilepsia; epileptiform; epileptogenic; gamma-Aminobutyric Acid; gonadal steroids; innovate; innovation; innovative; interest; male; medical schools; neurobiological; neurobiological mechanism; neurosteroids; nicotine addiction; novel; professor; programs; psychostimulant addiction; response; sex steroid; sham therapy; smoke cigarette; smoking cessation; stimulant addiction; stimulant dependence; tiagabine; tobacco addiction",Human Laboratory Studies for Stimulant Addiction,,21304,NIDA,Neuropharmacology Research Subcommittee,,3,127818,
7752804,K02,DA,5,,02/01/2010,01/31/2011,PA-00-020,5K02DA023200-03,,NIDA:123541;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"BLANCO, CARLOS ;",6069137;,5K02DA023200,02/01/2008,01/31/2013,"Activities, Educational; Address; Adolescent; Adolescent Youth; Alcohols; Area; Award; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Chemical Class, Alcohol; Clinic; Collaborations; Communities; Comorbidity; Conditioning Therapy; Detection; Development; Disease; Disorder; Drug abuse; Educational Activities; Effectiveness; Epidemiology; Ethics; Foundations; Funding; Goals; Health Care Research; Health Services Evaluation; Health Services Research; Healthcare Research; Hispanic Populations; Hispanics; Hispanics or Latinos; ISA; Independent Scientist Award; Institution; Intervention; Intervention Strategies; Investigators; K02 Award; Latino Population; Life Style Modification; Medical Care Research; Mentors; Methods; Outcome; Pathological Gambling; Pathological Gamblings; Population Group; Prevention; Programs (PT); Programs [Publication Type]; Psychiatric therapeutic procedure; Psychiatrist; Research; Research Personnel; Research Support; Researchers; Role; Scientist; Services; Spanish Origin; Substance abuse problem; Training; Work; abuse of drugs; abuse of substances; abuses drugs; addiction; behavior intervention; behavioral intervention; career; career development; community setting; disease/disorder; effectiveness research; hispanic community; improved; intervention development; interventional strategy; juvenile; juvenile human; programs; psychiatric care; psychiatric therapy; psychiatric treatment; services research; skills; social role; statistics/biometry; substance abuse; therapy development; treatment development; treatment program",Bridging Efficacy and Effectiveness in Drug Abuse Treatment,,23200,NIDA,Neuropharmacology Research Subcommittee,,3,123541,
7762193,K02,HL,5,,02/01/2010,01/31/2011,PA-00-020,5K02HL084179-05,,NHLBI:100440;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,PATHOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"YASEEN, NABEEL R;",1903433;,5K02HL084179,02/06/2007,01/31/2012,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; 4-Hydroxy-Tamoxifen; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; ABD-B; AML - Acute Myeloid Leukemia; AML1-ETO; AML1-ETO fusion protein; AML1-MTG8; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Appointment; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Blood (Leukemia); Blood Diseases; Blood erythrocyte; Blood granulocytic cell; Blood megakaryocyte; Blood normocyte; Bone Marrow; CD34; CD34 gene; CHIP assay; Cell Count; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Line; Cell Lines, Strains; Cell Number; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Chromosomal Rearrangement; Cicloheximide; Collaborations; Color; Combining Site; Commit; Coupled; Cycloheximide; DNA Binding; DNA Binding Interaction; DNA Rearrangement; DNA Sequence; Data; Diagnostic; Doctor of Philosophy; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysmyelopoietic Syndromes; Electrophoretic Mobility Shift Assay; Erythrocytes; Erythrocytic; Erythroid Cells; Erythroid Hyperplasia; Estrogen Receptors; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Expression Profiling; Expression Signature; Family; Funding; Fusion Protein; Gene Expression; Gene Expression Profile; Gene Rearrangement; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Granular Leukocytes; Granulocytic cell; Growth; HOX1.7; HOX1G; HOXA9; HOXA9 gene; HOXA9 protein; HPCA1; Hematologic Diseases; Hematological Disease; Hematological Disorder; Hematopathology; Hematopoietic; Homeo Boxes; Homeobox; Homeobox A9; Homeobox Protein 1G; Homeobox Protein A9; Homeobox Protein HOXA9; Homeodomain Protein HOXA9; Human; Human, General; ISA; Immunoblotting; Immunologic, Luciferase; In Vitro; Independent Scientist Award; Investigators; K02 Award; K22 Award; Leukemia, Myelocytic, Acute; Leukemias, General; Link; Luciferases; MGC1934; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mass Spectrum; Mass Spectrum Analysis; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Megakaryocytes; Megalokaryocyte; Methods; Mobility Shift Assay; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Mother Cells; Myeloblastic Leukemia, Acute; Myelodysplastic Syndromes; Myelogenous; Myelogenous Leukemia, Acute; Myeloid; N-terminal; NH2-terminal; National Heart, Lung, and Blood Institute; Nuclear Extract; Nuclear Pore Complex Proteins; Nucleoporins; Nup Protein; Oligonucleotide Array; Oligonucleotide Microarrays; Pathology; Patients; Pattern; Ph.D.; PhD; Photometry/Spectrum Analysis, Mass; Physicians; Population; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; RNA Expression; Reactive Site; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Design; Research Personnel; Researchers; Rest; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Erythrocytes; Role; Sampling; Scientist; Smoldering Leukemia; Sorting - Cell Movement; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Stem cells; Study Type; System; System, LOINC Axis 4; TAM; Tamoxifen; Targetings, Gene; Testing; Time; Tissue Growth; Transcription; Transcription, Genetic; Universities; abstracting; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; blood corpuscles; blood disorder; career; cell transformation; chromatin immunoprecipitation; cultured cell line; design; designing; gel shift assay; gene expression signature; gene product; granulocyte; hoxa-9 gene product; hoxa9 gene product; knock-down; leukemia; macrophage; molecuar profile; molecular signature; mouse model; myelodysplasia; ontogeny; overexpression; para-hydroxytamoxifen; peripheral blood; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; primitive cell; professor; progenitor; programs; protein protein interaction; self-renewal; single cell analysis; social role; sorting; stem; study design; tamoxifen metabolite B; transcription factor; transcriptome; transformed cells; vector",Nup98 Gene Rearrangements in Acute Myeloid Leukemia and Myelodysplastic Syndromes,,84179,ZHL1,Special Emphasis Panel,,5,100440,
7754080,K02,HL,5,,01/01/2010,12/31/2010,PA-06-527,5K02HL094692-02,,NHLBI:104166;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBUS,UNITED STATES,PHYSIOLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"ZIOLO, MARK T;",1875721;,5K02HL094692,01/01/2009,12/31/2013,"Action Potentials; Adenoviridae; Adenoviruses; Adrenergic Agents; Adrenergic Drugs; Adrenergics; Animals; Award; Biosensor; CNOS; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Signaling; Cells; Cellular biology; Collaborations; Constitutive NOS; Core Facility; Coupling; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Data; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; ENOS; Educational process of instructing; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Environment; Enzymes; Functional disorder; Funding; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanylyl Cyclase-Activating Factor Synthase; Heart; Heart Diseases; Heart myocyte; Hepatocyte Nitric Oxide Synthase; INOS; Inducible Nitric Oxide Synthase; Instruction; Intracellular Communication and Signaling; Isoforms; Knockout Mice; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Learning; Macrophage Nitric Oxide Synthase; Mass Spectrum; Mass Spectrum Analysis; Measures; Mediating; Medicine; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modification; Mononitrogen Monoxide; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocytes; Myocytes, Cardiac; NADPH-Diaphorase; NO Synthase; NOS 1 protein; NOS Type II; NOS Type III; NOS1; NOS1 gene; NOS2; NOS2A; NOS2A gene; NOS2A protein, human; NOS3; NOS3 gene; NOS3 protein, human; NOSIII; National Heart, Lung, and Blood Institute; Nerve Cells; Nerve Unit; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neurocyte; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 2A; Nitric Oxide Synthase 3; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Null Mouse; Ohio; Operation; Operative Procedures; Operative Surgical Procedures; PKG; Pathway interactions; Phosphorylation; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiology; Physiopathology; Production; Protein Isoforms; Protein Kinase G; Protein Phosphorylation; Proteins; Proteomics; Public Health; RNA, Small Interfering; Regulation; Research; Research Support; Science of Medicine; Services; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Surgical; Surgical Interventions; Surgical Procedure; Teaching; Techniques; Transgenic Mice; Universities; adrenergic; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; cardiomyocyte; cell biology; college; drug development; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; gene product; guanosine 3'5' monophosphate; heart disorder; heart function; human NOS2A protein; human NOS3 protein; iNOS enzyme; improved; innovate; innovation; innovative; nNOS enzyme; neuronal; neuronal nitric oxide synthase; nitric oxide synthase, Type II; novel; pathophysiology; pathway; phospholamban; professor; public health medicine (field); response; sensor (biological); siRNA; surgery; treatment strategy",Nitric oxide signaling in healthy and diseased cardiac myocytes,,94692,ZHL1,Special Emphasis Panel,,2,104166,
7759551,K02,HS,5,,02/01/2010,01/31/2011,PAR-99-164,5K02HS014010-06,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,WALTHAM,UNITED STATES,NONE,07,616845814,US,MA,024549110,BRANDEIS UNIVERSITY,"WITTENBERG, EVE ;",7932068;,5K02HS014010,02/01/2006,01/31/2011,,Evaluating Utility Measures: Biases and Alternatives,,14010,HCRT,HSR Health Care Research Training SS,,6,108895,
7761759,K02,HS,5,,02/01/2010,01/31/2011,PAR-07-444,5K02HS017950-02,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,CHAPEL HILL,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"JONSSON FUNK, MICHELE LAURA;",8218692;,5K02HS017950,02/01/2009,01/31/2014,,Doubly robust elimination: best practices for comparative effectiveness research,,17950,HCRT,HSR Health Care Research Training SS,,2,126263,
7808068,K02,MH,5,,02/01/2010,01/31/2011,PA-06-527,5K02MH084060-02,,NIMH:117855;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SIBILLE, ETIENNE L;",6277450;,5K02MH084060,04/20/2009,01/31/2014,"Affect; Affective; Affective Disorders; Alcohol dependence; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Area; Autopsy; Bio-Informatics; Bioinformatics; Biological; Brain; Brain region; Causality; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cessation of life; Clinical; DISSEC; Data; Death; Depressed mood; Depression; Disease; Disorder; Dissection; Drugs; Dysfunction; Economic Burden; Encephalon; Encephalons; Epidemiology, Family Medical History; Ethanol dependence; Etiology; Experimental Designs; Expression Profiling; Expression Signature; Family Medical History; Family history of; Follow-Up Studies; Followup Studies; Functional disorder; Future; Gene Expression; Gene Expression Profile; Gene Products, RNA; Genes; Genetic; Genetics, in situ Hybridization; Goals; Human; Human, General; In Situ Hybridization; Intracellular Communication and Signaling; Major Depressive Disorder; Man (Taxonomy); Man, Modern; Medication; Mental Depression; Molecular; Molecular Fingerprinting; Molecular Profiling; Mood Disorders; Nerve Cells; Nerve Unit; Nervous System, Brain; Network Analysis; Network-based; Neural Cell; Neurocyte; Neurons; Nuclear; Nucleus; Pathology; Pathway Analysis; Pathway interactions; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Process; Protocol; Protocols documentation; RNA; RNA, Non-Polyadenylated; Radiolabeled; Reaction; Regulation; Reporting; Research; Research Proposals; Ribonucleic Acid; Risk Factors; Sampling; Sex Functioning; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stress; Suicide; System; System, LOINC Axis 4; Testing; Time; Transcript; Validation; alcohol addiction; alcohol dependency; alcohol-dependent; amygdaloid nuclear complex; analytical tool; base; biological signal transduction; cingulate cortex; cohort; depressed; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; emotional expression; ethanol addiction; ethanol dependency; ethanol-dependent; experiment; experimental research; experimental study; expression of emotion; fatal attempt; fatal suicide; gene expression signature; gray matter; in situ Hybridization Staining Method; intent to die; major depression; model organism; molecuar profile; molecular pathology; molecular signature; mood regulation; mouse model; necropsy; neuronal; novel; novel therapeutic intervention; pathophysiology; pathway; postmortem; public health relevance; radiolabel; radiotracer; research study; sadness; sex; sexual functioning; showing emotion; substantia grisea; suicidal morbidity; suicidality; suicide death; suicide morbidity; transcriptome; transduction efficiency",Molecular characterization of a corticolimbic network in depression,,84060,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,117855,
7847487,K02,NS,5,,02/01/2010,01/31/2011,PA-06-527,5K02NS058760-03,,NINDS:179275;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WINSTON-SALEM,UNITED STATES,NEUROLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"BUSHNELL, CHERYL D;",6717349;,5K02NS058760,02/15/2008,01/31/2013,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 2 year old; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; AT III-protease complex; Acceleration; Androst-4-en-17beta-ol-3-one; Ankle; Apoplexy; Aquadiol; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atrial Fibrillation; Auricular Fibrillation; Biologic Marker; Biological; Biological Markers; Blood Coagulation Factor III; Blood Pressure; Blood Pressure, High; Blood Vessels; Brachial Artery; CD106; CD106 Antigens; CD142 Antigens; Carotid Arteries; Cause of Death; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Change of Life; Change of Life, Female; Chemotherapy-Hormones/Steroids; Climacteric; Coagulation Factor III; Coagulin; Coronary Disease; Coronary heart disease; Delta4-androsten-17beta-ol-3-one; Development; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Dysfunction; Endocrine Gland Secretion; Enrollment; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogenic Agents; Estrogenic Compounds; Estrogens; FSH; Factor III; Female Groups; Follicle Stimulating Hormone; Follitropin; Forearm; Functional disorder; Future; Gelatinase B; Generations; Glomerular Procoagulant Activity; Goals; Gonadal Steroid Hormones; Hormones; Hypertension; INCAM-110; INFLM; Incidence; Inducible Cell Adhesion Molecule 110; Inflammation; Investigation; Ischemia; Ischemic Stroke; Knowledge; Lead; Lipids; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Matrix Metalloproteinase-9; Measures; Mediating; Menopausal Status; Menopause; Modeling; Molecular Marker; Outcome; Outcome Study; Ovocyclin; Ovocylin; Pb element; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Physiologic; Physiologic pulse; Physiological; Physiopathology; Prevention; Prevention strategy; Preventive Intervention; Preventive strategy; Process; Progynon; Prothrombinase; Pulse; ROC Analyses; ROC Analysis; ROC Curve; Regio tarsalis; Research; Risk; Risk Factors; Ristocetin Cofactor; Ristocetin-Willebrand Factor; Sex Characteristics; Sex Differences; Sex Hormone-Binding Globulin; Sex Hormones; Sex Steroid Hormones; Sex Steroid-Binding Protein; Signature Molecule; Stress; Stroke; Structure of brachial artery; Study, Outcome; Tarsal Bone; Tarsus; Testosterone; Testosterone-Estradiol Binding Globulin; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Testosterone; Thrombase; Thrombin; Thrombin-Antithrombin Complex; Thromboplastin; Time; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Tobacco smoking; Trans-Testosterone; Type V Collagenase; Urothromboplastin; VCAM; VCAM-1; Vascular Accident, Brain; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weight Gain; Weight Increase; Woman; Women's Group; Work; acute coronary syndrome; antithrombin III-protease complex; arterial stiffness; atheromatosis; atherosclerotic vascular disease; biomarker; blood vessel disorder; body weight gain; body weight increase; brachial artery; brain attack; cardiovascular risk; cardiovascular risk factor; case control; cerebral vascular accident; cohort; coronary disorder; design; designing; disability; disease/disorder; enroll; fasting glucose; fibrinogenase; gender difference; gonadal steroids; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; indexing; men; men's; menopausal; mid life; mid-life; middle age; middle aged; midlife; novel; pathophysiology; peripheral blood vessel disorder; preventional intervention strategy; response; sex; sex steroid; sexual dimorphism (noncellular); stroke; thrombin-antithrombin III complex; two year old; vWF; vascular; von Willebrand Factor; von Willebrand Protein; wt gain",Sex Differences in Vascular Markers of Stroke Risk,,58760,NST,Training Grant and Career Development Review Committee,,3,179275,
7766986,K05,DA,5,,03/01/2010,02/28/2011,PA-00-021,5K05DA000454-10,,NIDA:126360;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HOUSTON,UNITED STATES,PSYCHIATRY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"KOSTEN, THOMAS RICHARD;",1881492;,5K05DA000454,04/01/2000,02/28/2011,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 3,4-Dihydroxyphenethylamine, ascorbate[{..}]oxygen oxidoreductase (beta-hydroxylating); 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-; 5HT transporter; 5HTT protein; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Abuse, Cocaine; Academy; Active Follow-up; Adanon; Addiction, Cocaine; Addiction, Opiate; Address; Althose; American; Amfebutamone; Antabuse; Antibodies; Award; Behavioral; Biologic Marker; Biological Markers; Bis(diethylthiocarbamoyl) Disulfide; Bp50; Buprenorphine; Bupropion; CD40; CDW40; Clinical Trials; Clinical Trials Network; Clinical Trials, Phase II; Clinical Trials, Unspecified; Cocaine; Cocaine Abuse; Cocaine Dependences; Cognitive; Comorbidity; Consultations; Coping Skills; Coupled; DBH; Dependence, Opiate; Dependences, Cocaine; Disulfiram; Dolophine; Dopamine Reuptake Inhibitors; Dopamine Uptake Inhibitors; Dopamine beta-Hydroxylase; Dopamine-beta-monooxygenase; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Therapy; Education; Educational aspects; Faculty; Forecast of outcome; Funding; GABA Agents; GABA Agonists; GABA Receptor; GABA Receptor Agonists; GABAergic Agents; Genetic Polymorphism; Goals; Human; Human, General; Information Dissemination; Injection of therapeutic agent; Injections; Intermediary Metabolism; International; Investigators; K05 Mechanism; K05 Program; Laboratories; Leadership; METBL; MGC9013; Man (Taxonomy); Man, Modern; Mentors; Metabolic Processes; Metabolism; Methadone; Methadose; Moab, Clinical Treatment; Molecular Marker; Monoclonal Antibodies; NIDA; National Institute of Drug Abuse; New England; Northeastern United States; Opiate Addiction; Opioid; Outcome; Outcome Measure; PBO; Patient Self-Report; Patients; Pharmacogenetics; Pharmacotherapy; Phase; Phase 2 Clinical Trials; Phase II Clinical Trials; Placebo Control; Placebos; Polymorphism (Genetics); Polymorphism, Genetic; Prognosis; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psychiatry; Publishing; Randomized; Randomized Clinical Trials; Receptors, gamma-Aminobutyric Acid; Regimen; Research; Research Personnel; Research Scientist Award; Researchers; Role; Running; SSRI; Safety; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Self-Report; Sham Treatment; Signature Molecule; Skills, Coping; TNFRSF5; TNFRSF5 gene; Testing; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Tetraethylthiuram Disulfide; Therapeutic; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-; Time; Toxicology; Training; Training Activity; Trials, Randomized Clinical; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Urinary System, Urine; Urine; Vaccinated; Vaccination; Vaccines; Variant; Variation; Work; addiction; base; biomarker; buproprion; clinical investigation; cocaine use; contingency management; design; designing; dopamine beta hydroxylase; effective therapy; efficacy testing; follow-up; gamma-Aminobutyric Acid Agents; gamma-Aminobutyric Acid Agonists; immunogenicity; improved; innovate; innovation; innovative; opioid addiction; opioid dependence; outcome forecast; p50; phase 2 study; phase 2 trial; phase II trial; polymorphism; programs; protocol, phase II; randomisation; randomization; randomly assigned; response; serotonin reuptake inhibitor; serotonin transporter; sham therapy; social role; sodium-dependent serotonin transporter; study, phase II; treatment response",Comorbidity in  Cocaine and Opioid Pharmacotherapy,,454,NIDA,Neuropharmacology Research Subcommittee,,10,126360,
7753836,K05,DA,5,,02/01/2010,01/31/2011,,5K05DA017648-03,,NIDA:113724;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HSER, YIH-ING ;",1887833;,5K05DA017648,02/22/2008,01/31/2013,"American; Archives; Area; Award; Books; California; Clinical; Communities; Complement; Complement Proteins; Consult; Crime; Criminal Justice; Data; Dedications; Development; Discipline; Drug Evaluation; Drug abuse; Drug usage; Drugs; Educational Mainstreaming; Ensure; Epidemiology; Evaluation; Evaluation Studies, Drug; Generalized Growth; Goals; Growth; ISA; Imprisonment; Independent Scientist Award; Institutes; Interdisciplinary Research; Interdisciplinary Study; Investigators; Journal Article; Journal Article (PT); Journal Article [Publication Type]; Journals; Justice, Criminal; K02 Award; K05 Award; Knowledge; Leadership; Literature; Magazine; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Medication; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mentors; Mentorship; Method LOINC Axis 6; Methodology; Models, Statistical; Multidisciplinary Collaboration; Multidisciplinary Research; Outcome; PROV; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Prevention; Principal Investigator; Probabilistic Models; Process; Programs (PT); Programs [Publication Type]; Provider; Psychiatry; Psychological Health; Public Health; Publishing; R01 Mechanism; R01 Program; RPG; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist Award; Services; Social Policies; Staging; Statistical Methods; Statistical Models; Students; Study Type; Study, Interdisciplinary; Substance abuse problem; System; System, LOINC Axis 4; Time; Tissue Growth; Training; Treatment Efficacy; Treatment outcome; Update; Work; abuse of drugs; abuse of substances; abuses drugs; biobehavior; biobehavioral; career; career development; drug use; drug/agent; experience; improved; incarceration; innovate; innovation; innovative; interest; journal article; neuropsychiatric; neuropsychiatry; ontogeny; programs; psychosocial; public health medicine (field); scientific accomplishments; scientific advances; skills; study design; substance abuse; therapeutic efficacy; therapeutically effective; treatment strategy; web site","Drug Abuse: Epidemiology, Treatment  Process, & Outcomes",,17648,NIDA,Neuropharmacology Research Subcommittee,,3,113724,
7761761,K08,AI,5,,02/01/2010,01/31/2011,PA-06-512,5K08AI072365-03,,NIAID:119529;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PITTSBURGH,UNITED STATES,PEDIATRICS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"NOWALK, ANDREW J;",1927856;,5K08AI072365,02/15/2008,01/31/2011,"Active Immunization; Advisory Committees; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Antisera; Area; Arthritis; Articulation; B. burgdorferi; B.burgdorferi; Bacteria; Bacteria sigma factor KatF protein; Basic Research; Basic Science; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blood; Blood Serum; Body Tissues; Borrelia; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; C3H/HeJ Mouse; Carditis; Cell/Tissue, Immunohistochemistry; Cells; Chickens; Clinical; Communicable Diseases; Complement; Complement Proteins; Complex; Data; Development; Diagnosis; Differential Gene Expression; Digestion; Effectiveness; Environment; Exposure to; Family; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Family; Gene Products, RNA; Generalized Growth; Genes; Growth; Head and Neck, Salivary Glands; Heart; History; Human; Human, General; Humoral Immunities; IHC; Immune Sera; Immunities, Humoral; Immunity; Immunization; Immunization, Passive; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; In Vitro; Incidence; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Institution; Investigation; Investigators; Ixodes; Ixodes (genus); Ixodes tick; Ixodida; Joints; KatF protein, Bacteria; Knock-out; Knockout; Laboratories; Life Cycle; Life Cycle Stages; Lipoproteins; Lyme Borreliosis; Lyme Disease; Lyme Disease Spirochete; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Marketing; Membrane; Membrane Proteins; Membrane-Associated Proteins; Mentors; Mice; Midgut; Modeling; Molecular; Murine; Mus; Needles; North America; Order Spirochaetales; Organ; OspA; OspA protein; OspA vaccine; Parents; Passive Immunization; Pathogenesis; Pathology; Pattern; Plasmids; Play; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteome; Proteomics; Public Health; RNA; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Reagent; Recombinants; Recording of previous events; Regulation; Reporting; Research; Research Activity; Research Design; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; RpoS; Salivary Glands; Sensitization, Immunologic; Sensitization, Immunological; Serologic; Serological; Serum; Simulate; Site; Skin; Specificity; Spirochaetales; Spirochetes; Staging; Stimulus; Study Type; Surface; Surface Proteins; Symptoms; Task Forces; Temperature; Testing; Ticks; Time; Tissue Growth; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Training; Training Programs; Transmission; United States; Universities; Vaccines; Withdrawal; Work; antibody-based immunity; arthritic; base; borrelial; career; cross reactivity; design; designing; experience; experiment; experimental research; experimental study; feeding; gene product; genetic manipulation; homologous recombination; immunogenic; life course; lyme spirochete; lyme vaccine; maltose-binding protein; member; membrane structure; model organism; mouse model; mutant; new diagnostics; next generation diagnostics; novel diagnostics; ontogeny; outer surface protein A; overexpression; paralog; paralogous gene; programs; protein B; protein expression; public health medicine (field); research study; response; reverse transcriptase PCR; rpoS protein, Bacteria; sigma factor 38 protein, Bacteria; sigma factor KatF protein, Bacteria; sigma factor S protein, Bacteria; sigma(38) protein, Bacteria; sigma(S) protein, Bacteria; social role; statistics/biometry; study design; tissue tropism; tool development; transmission process; vector",The Role of BBI36/38 in Lyme Disease Pathogenesis,,72365,MID,Microbiology and Infectious Diseases Research Committee,,3,119529,
7756606,K08,AI,5,,02/01/2010,01/31/2011,PA-06-512,5K08AI076633-03,,NIAID:115190;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"PRESTI, RACHEL MARGARET;",8924146;,5K08AI076633,02/01/2008,01/31/2011,"Adaptor Protein; Adaptor Signaling Protein; Animal Model; Animal Models and Related Studies; Animals; Apicomplexa; Babesia; Biological Terrorism; Bioterrorism; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; Categories; Cats; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cessation of life; Cryptosporidium; Cyst; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytotoxic cell; Data; Death; Dendritic Cells; Disease; Disease Outbreaks; Disorder; Domestic Cats; Dose; Edodekin Alfa; Environment; Epithelial Cells; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Food; Food Supply; Genetic; Grant; Gut Inflammation; Hematopoietic; Human; Human, General; IHC; IL-10; IL-12; IL10; IL10A; IL12; INFLM; Ileitis; Immune Function, Cellular; Immune response; Immunity; Immunity, Innate; Immunity, Mucosal; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Receptors; Immunological Receptors; Immunology; Immunology (Including BRMP); Immunology (NCI Program); In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Diseases of the Intestinal Tract; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Ingestion; Interleukin 10 Precursor; Interleukin-10; Interleukin-12; Intestinal; Intestinal Diseases; Intestinal Disorder; Intestinal Inflammation; Intestines; Intracellular Communication and Signaling; Investigators; K lymphocyte; Kinetic; Kinetics; LYT3; Lead; Libraries; Ligands; Lymphocyte; Lymphocytic; Lytotoxicity; Malaria; Mammals, Cats; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Meat; Mediating; Messenger RNA; Mice; Modeling; Mouse Strains; Mucosal Immunity; Murine; Mus; NK Cells; NKSF; Natural Immunity; Natural Killer Cell Stimulatory Factor; Natural Killer Cells; Nature; Necrosis; Necrotic; Oocysts; Oral; Outbreaks; Paludism; Parasites; Parasitic infection; Pb element; Piroplasma; Plasmodium; Plasmodium Infections; Predisposition; Production; Programs (PT); Programs [Publication Type]; Protozoa; Protozoal; Protozoan Infections; Public Health; RNA, Messenger; Receptor Protein; Receptors, Immunologic; Recruitment Activity; Regulation; Relative; Relative (related person); Reporter; Research Personnel; Researchers; Reticuloendothelial System, Spleen; Risk; Role; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Spleen; Stress; Susceptibility; T-Cells; T-Lymphocyte; T. gondii; T. gondii infection; Testing; Thymus-Dependent Lymphocytes; Tissues; Toxoplasma; Toxoplasma gondii; Toxoplasma gondii Infection; Toxoplasmosis; United States; Veiled Cells; Wild Type Mouse; Work; anti-microbial; antimicrobial; biological signal transduction; bowel; cell transformation; cell type; cultured cell line; cytokine; cytotoxicity; disease/disorder; enteritis; experience; genetic manipulation; heavy metal Pb; heavy metal lead; host response; human disease; immune function; immune receptor; immunoresponse; infection mouth; insight; intestine disorder; intraepithelial; lymph cell; mRNA; macrophage; model organism; new therapeutics; next generation therapeutics; novel; novel therapeutics; oral infection; oral infectious; oral pathogen; pathogen; programs; protozoal infection; public health medicine (field); receptor; recruit; response; social role; thymus derived lymphocyte; tool; transformed cells; waterborne",The Role of NKG2D/DAP10 in Toxoplasma gondii Infection,,76633,MID,Microbiology and Infectious Diseases Research Committee,,3,115190,
7806660,K08,AT,5,,02/01/2010,01/31/2011,PA-06-512,5K08AT004718-02,,NCCAM:124929;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SOWA, GWENDOLYN A;",8571929;,5K08AT004718,05/01/2009,01/31/2014,"1 year old; 2-Amino-2-Deoxyglucose; Acids; Address; Affect; Age; Aging Process; Aging-Related Process; Alternative Therapies; Animal Model; Animal Models and Related Studies; Assay; Autoregulation; Bioassay; Bioavailability; Biochemical Pathway; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Biological Models; Biomechanics; Body Tissues; CDC; COX-2 protein; COX2; COX2 enzyme; Cartilage; Cartilagenous Tissue; Catabolism; Cell Culture Techniques; Cell-Extracellular Matrix; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Chondroitin; Clinical Research; Clinical Study; Clinical Treatment; Collagen; Cyclo-Oxygenase-2; Cyclooxygenase; D-Glucose, 2-amino-2-deoxy-; Data; Development; Diet Supplement; Dietary Supplements; Dinoprostone; Drugs; ECM; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Equilibrium; Extracellular Matrix; Factor Analyses; Factor Analysis; Fatty Acids, Omega-3; Future; Gene Expression; Genes, Structural; Glucosamine; Glucosamine Sulfate; Goals; Height; Hepatocyte Nitric Oxide Synthase; Histology; Homeostasis; Human; Human, General; Hydrogen Oxide; INFLM; INOS; In Vitro; InAs; Inducible Nitric Oxide Synthase; Inflammation; Inflammatory; Instruction; Intermediary Metabolism; Intervention; Intervention Strategies; Intervertebral Disc Degenerative Disease; Intervertebral Disc Degenerative Disorder; Intervertebral Disk; Intervertebral disc structure; Investigation; Laboratories; Lead; Low Back Ache; Low Back Pain; Low Backache; Lumbago; METBL; MR Imaging; MR Tomography; MRI; Macrophage Nitric Oxide Synthase; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanical Stimulation; Mechanical Stress; Mechanics; Mediator; Mediator of Activation; Mediator of activation protein; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Metabolic Networks; Metabolic Processes; Metabolism; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Molecular; Mononitrogen Monoxide; Motion; Movement; NITEGE; NMR Imaging; NMR Tomography; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear Magnetic Resonance Imaging; Nutritional; Nutritional Supplement; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Operation; Operative Procedures; Operative Surgical Procedures; Oral; Oryctolagus cuniculus; Outcome; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PTGS2; Pathway interactions; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiologic Availability; Physiological; Physiological Homeostasis; Process; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Proteoglycan; Protocols, Treatment; RGM; Rabbit, Domestic; Rabbits; Regimen; Regulatory Pathway; Reporting; Research; Robot; Role; Spinal Column; Spine; Staging; Stimulus; Stress; Stress, Mechanical; Structural Genes; Sulfate, Glucosamine; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Testing; Tissues; Training; Translating; Translatings; Translations; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Vertebral column; Water; Whole Organism; Work; Yoga; Zeugmatography; aggrecan; aggrecanase; alternative treatment; backbone; balance; balance function; base; bioavailability of drug; body movement; chronic back pain; cyclo-oxygenase II; cyclooxygenase 2; design; designing; drug/agent; endothelial cell derived relaxing factor; experience; heavy metal Pb; heavy metal lead; human NOS2A protein; iNOS enzyme; in vivo; in vivo Model; indexing; indium arsenide; inhibitor; inhibitor/antagonist; interventional strategy; intervertebral disk degeneration; kinematics; language translation; metalloproteinase (general); model organism; n-3 Fatty Acids; nitric oxide synthase, Type II; novel; nucleus pulposus; omega-3; one year old; pathway; prevent; preventing; programs; prostaglandin H synthase-2; protective effect; public health relevance; response; simulation; social role; surgery; therapeutic target; trial regimen; trial treatment",Alternative treatments for disc degeneration: Effects on matrix homeostasis,,4718,ZAT1,Special Emphasis Panel,,2,124929,
7758323,K08,DK,5,,02/01/2010,01/31/2011,PA-00-003,5K08DK069385-05,,NIDDK:132705;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"HABTEZION, AIDA ;",7935450;,5K08DK069385,02/10/2006,01/31/2011,"Adhesion Molecule; Adhesions; Adoptive Cell Transfers; Antibiotic Therapy; Antibiotic Treatment; Antibodies, Blocking; Area; Assay; Bioassay; Biologic Assays; Biological Assay; Blocking Antibodies; Body Tissues; Cell Adhesion Molecules; Cell Count; Cell Number; Cell Transfers, Adoptive; Cell/Tissue, Immunohistochemistry; Cells; Chronic; Cola; Colitis; Colon; Cytofluorometry, Flow; Defect; Endothelial Cells; Epithelial Cells; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gastrointestinal Tract, Small Intestine; Genus Cola; Home; Home environment; Homing; IHC; INFLM; Immune; Immune response; Immunohistochemistry; Immunohistochemistry Staining Method; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intestines, Small; Keratin; Lamina Propria; Large Intestine; Leukocyte Trafficking; Lymphocyte; Lymphocyte Subpopulations; Lymphocyte Subset; Lymphocytic; Mammals, Mice; Mediating; Mice; Microfluorometry, Flow; Modeling; Murine; Mus; Production; Role; Skin; Small Intestines; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; Thymus-Dependent Lymphocytes; Tissues; Work; base; cell adhesion protein; cytokine; flow cytophotometry; host response; immunoresponse; improved; in vivo; insight; large bowel; lymph cell; new therapeutic target; small bowel; social role; thymus derived lymphocyte; trafficking; treatment of bacterial diseases; treatment of bacterial infectious disease",Lymphocyte Homing Mechanisms in Normal & Inflamed Colon,,69385,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,5,132705,
7766205,K08,DK,5,,01/01/2010,12/31/2010,PA-06-512,5K08DK082783-02,,NIDDK:129870;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"RAMAKRISHNAN, ARAVIND ;",8930545;,5K08DK082783,02/06/2009,12/31/2013,"Address; Advisory Committees; Animals; Attention; Biotechnology; Blastocyst; Blastocyst structure; Blastosphere; Body Tissues; Canine Species; Canis familiaris; Cell Line; Cell Lines, Strains; Cell model; CellLine; Cells; Cellular model; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Communities; Degenerative Disorder; Development; Disease; Disorder; Dogs; ES cell; Embryo, Preimplantation; Embryonic Tissue; Environment; Ethics; Fibroblasts; Future; Generations; Genes; HSC transplantation; Hematopoietic; Hematopoietic Stem Cell Transplantation; High Throughput Assay; Histocompatibility; Human; Human, General; Insertional Mutagenesis; Investigation; Libraries; Mammals, Dogs; Mammals, Mice; Man (Taxonomy); Man, Modern; Mentorship; Mice; Modeling; Molecular and Cellular Biology; Moon; Mother Cells; Murine; Mus; Mutagenesis, Insertional; Oncogenesis; Outcome; Pathway interactions; Patients; Phenotype; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pre-Clinical Model; Preclinical Models; Principal Investigator; Process; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protocol; Protocols documentation; Publications; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Replacement Therapy; Reporter; Reporting; Research; Research Resources; Resources; Retroviral Vector; Retrovirus Vector; Risk; Rodent Model; Safety; Scientific Publication; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Skin; Stem Cell Research; Stem cells; Task Forces; Testing; Therapeutic; Tissue Compatibility; Tissue Donors; Tissues; Training; Training Programs; Translating; Translatings; Translations; Transplantation; Viral; Viral Vector; base; blastocyst; blastula; canine; cell type; clinical investigation; clinical relevance; clinically relevant; cultured cell line; degenerative condition; degenerative disease; design; designing; disease/disorder; domestic dog; embryo tissue; embryonic stem cell; experience; experiment; experimental research; experimental study; high throughput screening; in vivo Model; induced pluripotent stem cell; interest; language translation; man; man's; pathway; pre-clinical; preclinical; public health relevance; research study; retroviral transduction; retroviral-mediated; screening; screenings; small molecule; stem; stem cell of embryonic origin; theories; transcription factor; transplant; tumorigenesis",Generating iPS cells by reprogramming using small molecules,,82783,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,2,129870,
7759142,K08,EY,5,,02/01/2010,01/31/2011,PA-00-003,5K08EY017383-04,,NEI:232105;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"VELEZ, GISELA ;",8344088;,5K08EY017383,02/01/2007,01/31/2012,"ABL1; ABL1 gene; ATP[{..}]protein-tyrosine O-phosphotransferase; Abelson Murine Leukemia Viral Oncogene Homolog 1; Adverse effects; Antimorphic mutation; Applications Grants; Attenuated; Autocrine Systems; BCR-ABL Kinase; Bcr-Abl tyrosine kinase; CD117 Antigens; Cataract; Cells; Characteristics; Cicatrix; Clinical; Clinical Trials; Clinical Trials, Unspecified; Complement; Complement Proteins; Complex; Complication; Development; Disease; Disease model; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dose; Drug Kinetics; Drugs; Dysfunction; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epiretinal Membrane; Eye; Eyeball; FDA approved; Fibrosis; Forecast of outcome; Foundations; Functional disorder; Future; Genes, c-abl; Goals; Grant; Grant Proposals; Grants, Applications; HEK3; Human; Human, General; Imatinib mesylate; Incidence; Inferior; Institutes; Intervention; Intervention Strategies; Investigators; JTK7; Knowledge; Lead; MGF Stem Cell Factor; Macular degeneration; Macular degenerative disease; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor; Mast Cell Growth Factor Receptor; Medication; Mentored Clinical Scientist Development Award (K08); Mentored Clinical Scientists Development Award; Metabolic Clearance Rate; Methods and Techniques; Methods, Other; Modeling; Molecular; Operation; Operative Procedures; Operative Surgical Procedures; Oryctolagus cuniculus; Outer pigmented layer of retina; PDGF; PDGFR; PTK; PTK Inhibitors; Patient Care; Patient Care Delivery; Patients; Pb element; Ph 1 Chromosome; Ph Negative CML; Ph Negative Chronic Myelogenous Leukemia; Ph' Chromosome Negative Chronic Granulocytic Leukemia; Ph' Chromosome Negative Chronic Myelocytic Leukemia; Ph' Chromosome Negative Chronic Myeloid Leukemia; Ph' Negative Chronic Granulocytic Leukemia; Ph- Chronic Myelogenous Leukemia; Ph1 Chromosome; Ph1 Chromosome Negative Chronic Myelocytic Leukemia; Ph1 Chromosome Negative Chronic Myelogenous Leukemia; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phased Career Development; Philadelphia Chromosome; Philadelphia Chromosome Negative CML; Philadelphia Chromosome Negative Chronic Granulocytic Leukemia; Philadelphia Chromosome Negative Chronic Myelocytic Leukemia; Philadelphia Chromosome Negative Chronic Myelogenous Leukemia; Philadelphia Chromosome Negative Chronic Myeloid Leukemia; Physiopathology; Pigment cell layer of retina; Pigmented layer of retina; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor Receptor; Play; Poisons; Prevention Measures; Prognosis; Programs (PT); Programs [Publication Type]; Proliferative Vitreoretinopathy; Prophylactic treatment; Prophylaxis; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase Inhibitors; Proto-Oncogene Protein c-kit; Rabbit, Domestic; Rabbits; Randomized Clinical Trials; Receptor Protein; Receptors, PDGF; Recovery; Research; Research Institute; Research Personnel; Researchers; Retina; Retinal Detachment; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Retinopathy of Prematurity; Retrolental Fibroplasia; Retrolental Fibroplasias; Role; SCF Receptor; SCHED; STI 571; STI571; STI571 (Gleevec); Scars; Schedule; Scientist; Specificity; Steel Factor; Stem Cell Factor; Stem Cell Factor Receptor; Structure of retinal pigment epithelium; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TK Inhibitors; Techniques; Testing; Therapeutic; Time; Toxic Chemical; Toxic Substance; Toxic effect; Toxicities; Training; Treatment Side Effects; Trials, Randomized Clinical; Tyrosine Kinase; Tyrosine Kinase Inhibitor; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Visual; Vitreoretinopathy, Proliferative; Vitreous Hemorrhage; Work; autocrine; base; c abl; c kit; c-Abl; c-abl Proto-Oncogenes; c-kit Ligand; c-kit Protein; c-kit Receptor; career; cataractogenesis; cataractous lenses; clearance rate; clinical investigation; density; disease/disorder; disorder model; dosage; drug clearance; drug/agent; efficacy testing; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; high risk; human subject; hydroxyaryl protein kinase; improved; inhibitor; inhibitor/antagonist; injured; interventional strategy; kit Ligand; kit Proto-Oncogene Protein; neovascular; outcome forecast; p145(c-kit); p145c-kit; pathophysiology; poison; premature retinopathy; prevent; preventing; programs; proliferative diabetic retinopathy; receptor; research study; retina detachment; side effect; skills; social role; surgery; therapy adverse effect; tool; toxic compound; treatment adverse effect; tyrosyl protein kinase",Pharmacologic inhibitors of PDGFR for the treatment of PVR,,17383,ZEY1,Special Emphasis Panel,,4,232105,
7760085,K08,EY,5,,02/01/2010,01/31/2011,PA-06-512,5K08EY018677-03,,NEI:127926;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,071723084,US,MA,02215,JOSLIN DIABETES CENTER,"RASK-MADSEN, CHRISTIAN ;",8909914;,5K08EY018677,02/01/2008,01/31/2013,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 5'-AMP-activated protein kinase; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; Acute; Animal Model; Animal Models and Related Studies; Biology; C protein; CBP protein (citrate-binding); CNOS; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cell Communication and Signaling; Cell Culture Techniques; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular biology; Common Rat Strains; Complications of Diabetes Mellitus; Constitutive NOS; Data; Development; Diabetes Complications; Diabetes Mellitus; Diabetes-Related Complications; Diabetic Complications; Diabetic Retinopathy; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; ECNOS; ENOS; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Relaxing Factor; Evaluation; Fellowship; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; GFAC; Genetic; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; Injection of therapeutic agent; Injections; Institutes; Intracellular Communication and Signaling; Investigators; Isoforms; K-Awards; K-Series Research Career Programs; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Knock-out; Knockout; Knockout Mice; Knowledge; Laboratories; Mammals, Rats; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mentors; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Minor; Modeling; Molecular; Mononitrogen Monoxide; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Null Mouse; Outcome; PKC; Pathway interactions; Patients; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physicians; Play; Postdoc; Postdoctoral Fellow; Prevention; Process; Production; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Kinase C; Proteins; RNA, Small Interfering; Rat; Rat model of diabetes; Rattus; Receptor Protein; Research; Research Associate; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Retina; Retinal; Retinal Diseases; Retinal Disorder; Retinal Neovascularization; Role; STZ; Scientist; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small Interfering RNA; Streptozocin; Streptozotocin; Subcellular Process; Testing; Training; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptors; VEGFR; VEGFR-2; VEGFR2; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Permeabilities; Vascular Permeability Factor Receptor; Vegf; Wild Type Mouse; Work; Zanosar; angiogenesis; biological signal transduction; cell biology; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; diabetes; diabetic; diabetic rat; diabetic rat model; disease/disorder; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; gene product; human NOS3 protein; hydroxymethylglutaryl-CoA-reductase kinase; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; macular edema; model organism; mouse model; neovascularization; novel; overexpression; pathway; post-doc; post-doctoral; prevent; preventing; programs; proliferative diabetic retinopathy; receptor; research study; retina disease; retina disorder; retinopathy; siRNA; social role; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein",The role of PKCepsilon in diabetic retinopathy,,18677,ZEY1,Special Emphasis Panel,,3,127926,
7762219,K08,EY,5,,02/01/2010,01/31/2011,PA-06-512,5K08EY018874-02,,NEI:240079;,2010,NATIONAL EYE INSTITUTE,,CHICAGO,UNITED STATES,OPHTHALMOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"JAIN, SANDEEP ;",9093999;,5K08EY018874,02/01/2009,01/31/2014,"Accountability; Address; Antibodies; Area; Axon; Basic Research; Basic Science; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Chicago; Collagen Type XVIII; Cornea; Corneal Transplantation; Coupled; Cues; DNA Molecular Biology; Data; EPH Tyrosine Kinase 2; EPHT2 Protein; EphB1 Protein; Ephrin Receptor EphB1; Ephrin Type-B Receptor 1; Eye; Eyeball; Fibroblasts; Gasser's Ganglion; Gasserian Ganglion; Generalized Growth; Grafting, Corneal; Growth; Illinois; In Vitro; Intracellular Communication and Signaling; Investigation; Keratectomy, Excimer Laser; Keratectomy, Photorefractive, Excimer Laser; Keratectomy, Phototherapeutic, Excimer Laser; Keratoplasty; Knockout Mice; Learning; Ligands; Lions; Mammals, Mice; Mediating; Medical; Mentored Clinical Scientist Development Award (K08); Mentored Clinical Scientists Development Award; Mentors; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Biology; Molecular and Cellular Biology; Murine; Mus; Myofibroblast; Natural regeneration; Nerve; Nerve Cells; Nerve Regeneration; Nerve Unit; Nervous; Neural Cell; Neurobiology; Neurocyte; Neuronally Expressed EPH-Related Tyrosine Kinase; Neurons; Neurosciences; Null Mouse; Panthera leo; Pattern; Perinatal; Phased Career Development; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proliferating; R01 Mechanism; R01 Program; RNA, Small Interfering; RPG; Receptor Protein; Receptor, EphB1; Regeneration; Research Grants; Research Institute; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Role; Scientist; Semilunar Ganglion; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Staging; Structure; Structure of trigeminal ganglion; Supervision; System; System, LOINC Axis 4; Testing; Tissue Growth; Training; Transplantation; Transplantation, Cornea; Trigeminal Ganglias; Trigeminal Ganglion; Tyrosine-Protein Kinase Receptor EPH-2; Universities; Work; Wound Healing; Wound Repair; XVIII Collagen; axonal guidance; biological signal transduction; biomedical scientist; conference; corneal; corneal keratoplasty; corneal transplant; cultured cell line; experiment; experimental research; experimental study; in vivo; nervous system regeneration; neural regeneration; neurobiological; neuronal; neuronal guidance; novel; ontogeny; overexpression; programs; receptor; regenerate; reinnervation; research study; response; role model; siRNA; social role; symposium; tissue repair; transplant",Keratocyte role in guidance of corneal nerves,,18874,ZEY1,Special Emphasis Panel,,2,240079,
7835607,K08,GM,5,,02/01/2010,01/31/2011,PA-00-003,5K08GM073826-06,,NIGMS:85237;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,SURGERY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"RAGHAVENDRAN, KRISHNAN ;",8035518;,5K08GM073826,02/01/2006,01/31/2011,"21+ years old; ARDS; ARDS, Human; ARDSs, Human; ASPR; Acids; Acute; Acute Pulmonary Injury; Admission; Admission activity; Adult; Adult RDS; Adult Respiratory Distress Syndrome; Alveolar Macrophages; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animals; Aspirate; Aspirate substance; Bilateral; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blunt Injuries; Blunt Trauma; Bruise; CCL2; CCL2 gene; Candidate Disease Gene; Candidate Gene; Cause of Death; Chest; Clinical; Common Rat Strains; Complement; Complement Proteins; Contusions; Cytokines, Chemotactic; Development; Dysfunction; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Expression Profiling; Expression Signature; Food; Functional disorder; GDCF-2; GDCF-2 HC11; Gastric Acid; Genomics; HC11; HOSP; Heart; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Hospitals; Human, Adult; Hydrochloric Acid, Gastric; Inflammatory; Inflammatory Response; Injuries, Nonpenetrating; Injury; Intercrines; Laboratories; Lung; Lung Injury, Acute; MCAF; MCP-1; MCP1; MGC9434; Macrophages, Alveolar; Mammals, Rats; Marrow Neutrophil; Mediastinal; Mediating; Microarray Analysis; Microarray-Based Analysis; Modality; Modeling; Molecular Fingerprinting; Molecular Profiling; Mortality; Mortality Vital Statistics; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nonpenetrating Wounds; Particulate; Pathogenesis; Pathway interactions; Patients; Physiopathology; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prospective Studies; Pulmonary Macrophages; RT-PCR; RTPCR; Rat; Rattus; Resolution; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Role; SCYA2; SIS cytokines; SMC-CF; Shock Lung; Simulate; Stomach; Structure; Therapeutic; Thorace; Thoracic; Thorax; Trauma; Weight; Work; acute lung injury; adult human (21+); base; chemoattractant cytokine; chemokine; falls; gastric; improved; lung injury; microarray technology; model organism; molecuar profile; molecular signature; neutrophil; new diagnostics; next generation diagnostics; novel; novel diagnostics; particle; pathophysiology; pathway; pulmonary; respiratory; response; reverse transcriptase PCR; social role; treatment strategy",Lung Contusion-Mechanisms and Interaction with Aspiration,,73826,SAT,"Surgery, Anesthesiology and Trauma Study Section",,6,85237,
7752872,K08,GM,5,,01/01/2010,12/31/2010,,5K08GM083154-03,,NIGMS:116030;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WINSTON-SALEM,UNITED STATES,SURGERY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"HOTH, JAMES JASON;",8875106;,5K08GM083154,01/01/2008,12/31/2012,"4q Chemokine; ARDS; ARDS, Human; ARDSs, Human; Accounting; Admission; Admission activity; Adult RDS; Adult Respiratory Distress Syndrome; Advisory Committees; Affect; Antibodies; Area; Biochemical; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blunt Trauma; Breathlessness; Bruise; C-X-C Chemokines; CD54 (ICAM 1); CD54 Antigens; CXC Chemokines; CXCL1; CXCL1 gene; Cells; Cessation of life; Chest; Chest Injuries; Clinical; Clinical Pathology; Complement; Complement Proteins; Contusions; Death; Development; Doctor of Philosophy; Dysfunction; Dyspnea; Dyspneas; EXTMR; Extramural; Extramural Activities; FLR; Failure (biologic function); Functional disorder; GRO1; GROA; Genetic; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Heterophil Granulocyte; Human; Human, General; ICAM-1; INFLM; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Infection; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Injury; Intercellular adhesion molecule 1; Investigators; Lung; MGSA; MOF syndrome; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Mechanical ventilation; Mediating; Melanoma Growth Stimulatory Activity, Alpha, Gene; Mentored Clinical Scientist Development Award (K08); Mentored Clinical Scientists Development Award; Mentors; Mentorship; Methods; Mice; Modeling; Molecular; Molecular Medicine; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Organ Failure; Murine; Mus; NAP-3; NIGMS; National Institute of General Medical Sciences; Natural Immunity; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organ Dysfunction Syndrome, Multiple; Organ failure; Pathogenesis; Pathology; Pathology, Clinical; Patients; Ph.D.; PhD; Phased Career Development; Physiologic; Physiological; Physiopathology; Pneumonia; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Pulmonary Inflammation; R01 Mechanism; R01 Program; RPG; Receptor Protein; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Respiratory physiology; Role; SCYB1; Severities; Shock Lung; Source; Stimulus; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TIL4; TLR protein; TLR1; TLR1 protein; TLR1 receptor; TLR2; TLR2 gene; TLR4; TLR4 gene; TOLL; Task Forces; Testing; Thorace; Thoracic; Thoracic Injuries; Thorax; Toll-Like Receptor 1; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin-1 Receptor-Like; Training; Trauma; Viral; Wild Type Mouse; adapter protein; adhesion receptor; alpha-Chemokines; career development; education planning; failure; hToll; host response; immunoresponse; injured; insight; lung function; lung injury; mechanical respiratory assist; member; mouse model; multiple organ system failure; neutrophil; novel; pathogen; pathophysiology; posttraumatic respiratory insufficiency; pulmonary; receptor; respiratory function; response; social role; surgery; traumatic lung",The Molecular and Cellular Response to Pulmonary Contusion,,83154,SAT,"Surgery, Anesthesiology and Trauma Study Section",,3,116030,
7752557,K08,HD,5,,01/01/2010,12/31/2010,PA-00-003,5K08HD049598-05,,NICHD:128251;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CHICAGO,UNITED STATES,SURGERY,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"ZHANG, YEJIA ;",6093176;,5K08HD049598,01/20/2007,12/31/2010,"Abscission; Address; Adenoviridae; Adenoviruses; Allogenic; Animals; Attention; Autoregulation; BMP-7; BMP7; BMP7 protein, human; Back Ache; Back Pain; Backache; Basic Research; Basic Science; Biochemical; Biological; Body Tissues; Bone Morphogenetic Proteins; Causality; Cell Count; Cell Number; Cell Survival; Cell Therapy; Cell Viability; Cells; Chondrocytes; Clinical; Collagen; Collagen Type II; Control Groups; Conventional X-Ray; Data; Development Plans; Development and Research; Diagnostic Radiology; Diagnostic radiologic examination; ELISA; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; Excision; Expertise, Technical; Extirpation; Fluorescence Microscopy; GFAC; GFP; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Green Fluorescent Proteins; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H+ element; Height; Homeostasis; Hydrogen Ions; Image; In Vitro; Injection of therapeutic agent; Injections; Injury; International; Intervention, Genetic; Intervertebral Disc Degenerative Disease; Intervertebral Disc Degenerative Disorder; Intervertebral Disk; Intervertebral disc structure; Investigators; Learning; Letters; Low Back Ache; Low Back Pain; Low Backache; Lumbago; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Mammals, Rabbits; Manuscripts; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, X-Ray; Mentors; Methods; Methods and Techniques; Methods, Other; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular Biology, Gene Therapy; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; OP-1; OP-1 protein; OP-1 protein, human; OP1; Operation; Operative Procedures; Operative Surgical Procedures; Oryctolagus cuniculus; Osteogenic Protein 1; Outcome Measure; Phenotype; Physical Health Services / Rehabilitation; Physicians; Physiologic; Physiological; Physiological Homeostasis; Plans, Development; Production; Programs (PT); Programs [Publication Type]; Proteins; Proteoglycan; Protons; Publishing; Puncture procedure; Punctures; R & D; R&D; RT-PCR; RTPCR; Rabbit, Domestic; Rabbits; Radiography; Radiology, Diagnostic X-Ray; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Removal; Research; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Roentgenography; Role; Scientist; Seasons; Spinal Column; Spine; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Technical Expertise; Techniques; Therapy, Cell; Therapy, DNA; Tissues; Training; Training Programs; Transduction Gene; Transplantation; United States; Universities; Vector Mediated Transfer Genes; Vertebral column; Weight; Work; X-Ray Imaging; X-Ray, Diagnostic; Zeugmatography; abstracting; aggrecan; aging population; backbone; base; bone morphogenetic protein 7; bone morphogenetic protein 7, human; career; career development; cell-based therapy; cost; density; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; economic impact; experience; gene product; gene therapy; genetic therapy; human osteogenic protein 1; imaging; in vivo; indexing; injured; interest; intervertebral disk degeneration; meetings; osteogenic protein 1, human; programs; rehabilitative; repair; repaired; research and development; resection; reverse transcriptase PCR; social role; surgery; tool; transfer of a gene; transplant",Cell Therapy for the degenerating intervertebral discs,,49598,ZHD1,Special Emphasis Panel,,5,128251,
7758755,K08,HL,5,,02/01/2010,01/31/2011,PA-00-003,5K08HL080212-04,,NHLBI:122820;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"STAUFFER, BRIAN L;",6679495;,5K08HL080212,02/01/2007,01/31/2012,"ATP-protein phosphotransferase; Advisory Committees; Animal Model; Animal Models and Related Studies; Area; Attenuated; Basic Research; Basic Science; Biochemistry; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiology; Cardiomyopathies; Cardiomyopathy, Hypertrophic Obstructive; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular system; Cardiovascular system (all sites); Caseins; Cell Communication and Signaling; Cell Signaling; Chemistry, Biological; Clinical; Colorado; DISSEC; DNA Molecular Biology; Development; Diastolic heart failure; Diet; Diet Modification; Disease; Disorder; Dissection; Endocrinologist; Faculty; Generalized Growth; Gonadal Steroid Hormones; Growth; Heart Diseases; Heart failure; Hypertrophic Cardiomyopathy; Internal Medicine; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Knowledge; Lead; Location; Mammals, Mice; Mentors; Mice; Mice, Transgenic; Modeling; Modification; Modifications, Dietary; Molecular; Molecular Biology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Organ System, Cardiovascular; Pathway interactions; Pb element; Phenotype; Physiology; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Kinase; Research; Research Personnel; Research Resources; Researchers; Resources; Scientific Evaluation; Scientist; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Task Forces; Testing; Tissue Growth; Training; Training Programs; Transgenic Mice; Universities; Vascular, Heart; Woman; Work; abstracting; base; biological signal transduction; cardiac failure; career; circulatory system; disease/disorder; experimental analysis; flexibility; gender difference; glycogen synthase a kinase; gonadal steroids; heart disorder; heart failure with preserved systolic function; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; hypertrophic myocardiopathy; interventional strategy; male; men; men's; model organism; mouse model; myocardium disorder; ontogeny; pathway; phosphorylase b kinase kinase; prevent; preventing; programs; sex; sex steroid; sexual dimorphism (noncellular); soy; translational approach","Diet, Sex Steroids and Cardiomyopathy",,80212,ZHL1,Special Emphasis Panel,,4,122820,
7754452,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL084095-03,,NHLBI:132057;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,STANFORD,UNITED STATES,BIOCHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"DESAI, TUSHAR JASUBHAI;",6795974;,5K08HL084095,01/04/2008,12/31/2012,"21+ years old; Adult; Advisory Committees; Alveolar; Alveolar Cell; Alveolus; Anaplastic; Antibodies; Antigens, Differentiation; Area; Biochemistry; Body Tissues; Boston; Bronchial Alveolus; Cancer of Lung; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle Kinetics; Cell Differentiation; Cell Differentiation process; Cell Kinetics; Cell Signaling; Cells; Cellular biology; Chair; Chairman; Chairperson; Chairwoman; Chemistry, Biological; City of Boston; Critical Care; DNA Molecular Biology; DNA Recombination; DNA recombination (naturally occurring); Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Development; Differentiation Antigens; Differentiation Markers; Disease; Disorder; Distal; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Emphysema; Ensure; Epithelial Cells; Epithelium; Event; Fellowship; Funding; Gases; Gene Expression; Gene Products, RNA; General Transcription Factor Gene; Genes; Genetic; Genetic Recombination; Genetic Techniques; Genetics, in situ Hybridization; Genomics; Gestation; Goals; Health; Histology; Human, Adult; In Situ Hybridization; Indirect Immunofluorescence; Indirect Immunofluorescences; Individual; Institutes; Intracellular Communication and Signaling; Investigators; Label; Laboratories; Lung; Lung diseases; Maintenance; Maintenances; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Marker Antigens; Markers, Differentation; Medical; Medicine; Mentors; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Molecular; Molecular Biology; Molecular Genetic; Molecular Genetics; Mother Cells; Mouse Strains; Murine; Mus; Natural regeneration; Pathway interactions; Pattern; Phenotype; Physiology; Play; Pneumology; Pneumonology; Pregnancy; Principal Investigator; Progenitor Cells; Program Development; Programs (PT); Programs [Publication Type]; Proto-Oncogene, Transcription Factor; Protocol; Protocols documentation; Pulmonary Cancer; Pulmonary Disease (Specialty); Pulmonary Diseases; Pulmonary Disorder; Pulmonary Emphysema; Pulmonary Fibrosis; Pulmonary Medicine; Pulmonary Surfactant Protein C; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactant-Associated Protein SP-C; Pulmonary malignant Neoplasm; Pulmonology; RNA; RNA, Non-Polyadenylated; Recombination; Recombination, Genetic; Regeneration; Research; Research Personnel; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory Failure; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Ribonucleic Acid; Role; SP-C peptide; SP-C protein; Science of Medicine; Scientist; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specific qualifier value; Specified; Staging; Stem cells; Surfactant Polypeptide SP-C; Task Forces; Technics, Genetic; Techniques; Testing; Time; Tissues; Training; Training Programs; Transcription factor genes; Transgenic Mice; Undifferentiated; Universities; Work; adult human (21+); authority; base; biological signal transduction; career; cell biology; cell type; clinical data repository; clinical data warehouse; data repository; disease/disorder; experiment; experimental research; experimental study; genome, mouse; in situ Hybridization Staining Method; in vivo; instructor; lung Carcinoma; lung cancer; lung development; lung disorder; molecular marker; mouse development; mouse genome; pathway; professor; progenitor; programs; pulmonary; recombinase; regenerate; relational database; research study; respiratory insufficiency/failure; selective expression; selectively expressed; social role; surfactant; transcription factor",Development and maintenance of the alveolar type 1 cell,,84095,ZHL1,Special Emphasis Panel,,3,132057,
7754457,K08,HL,5,,01/01/2010,12/31/2010,PA-00-003,5K08HL086513-04,,NHLBI:121770;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"OISHI, PETER ERIC;",7902749;,5K08HL086513,01/01/2007,12/31/2010,"0-11 years old; Active Oxygen; Address; Advisory Committees; Affect; Age; Agonist; Anatomic; Anatomical Sciences; Anatomy; Attenuated; Bioavailable; Biochemical; Birth; Blood Circulation; Blood Vessels; Blood flow; Bloodstream; CNOS; California; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cardiopulmonary; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Child; Child Youth; Childhood; Children (0-21); Chronic; Circulation; Clinical; Congenital Heart Defects; Constitutive NOS; Critical Care; Data; Development; Disease; Disorder; Doctor of Medicine; Dose; Dysfunction; EC 1.14.13.39; ECNOS; EDN1; EDRF Synthase; ENOS; ET-1; ET-1 (Endothelin-1); Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelin A Receptor; Endothelin Type 1; Endothelin-1; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Environment; Exposure to; Family; Fellowship; Functional disorder; GUCY; Guanylyl Cyclase-Activating Factor Synthase; Harvest; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; History; Human, Child; In Vitro; Infant; Intracellular Communication and Signaling; Investigation; Investigators; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Laboratories; Lead; Left; Ligands; Light; Lung; M.D.; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Medicine; Mentorship; Messenger RNA; Methods and Techniques; Methods, Other; Modeling; Molecular; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NADPH Oxidase; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Organ System, Cardiovascular; Oxidative Stress; Oxygen Radicals; PPAR; PPAR gamma; PPARG; PPARG1; PPARG2; PPARgamma; Parturition; Pathology; Patients; Pb element; Peripheral; Peroxisome Proliferative Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor gamma; Peroxisome Proliferator-Activated Receptors; Peroxonitrite; Peroxonitrites; Peroxynitrites; Phenotype; Photoradiation; Physiologic; Physiological; Physiopathology; Pressure; Pressure- physical agent; Prevention; Principal Investigator; Pro-Oxidants; Process; Production; Program Development; Programs (PT); Programs [Publication Type]; Proteins; QOL; Quality of life; RNA, Messenger; Reaction; Reactive Oxygen Species; Receptor Protein; Receptor, Endothelin A; Receptor, Endothelin-1; Recording of previous events; Research; Research Institute; Research Personnel; Researchers; Respiratory System, Lung; Risk; Role; San Francisco; Science of Anatomy; Science of Medicine; Scientist; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase; Superoxide Anion; Superoxide Radical; Superoxides; Task Forces; Techniques; Testing; Thiazolidinedione Receptor; Time; Training; Training Programs; Universities; Vascular Diseases; Vascular Disorder; Vascular Graft; Vascular constriction (function); Vascular, Heart; Vasoconstriction; Vasodilatation; Vasodilation; Vasorelaxation; Vulnerable Populations; Work; abstracting; anatomy; biological signal transduction; blood vessel disorder; career; cell type; children; circulatory system; clinical relevance; clinically relevant; design; designing; disease/disorder; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; gene product; heart defect; heavy metal Pb; heavy metal lead; hemodynamics; human NOS3 protein; improved; in utero; in vivo; mRNA; member; multidisciplinary; nitric oxide receptor; nitric oxide-sensitive guanylyl cyclase; novel; pathophysiology; pediatric; peroxynitrite; pressure; prevent; preventing; professor; programs; pulmonary; pulmonary artery endothelial cell; receptor; research study; response; restoration; sGC; sGC protein; shear stress; skills; social role; treatment strategy; vascular; youngster",Vascular Dysfunction with Increased Pulmonary Blood Flow: A role for PPAR Gamma,,86513,ZHL1,Special Emphasis Panel,,4,121770,
7776931,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL086868-03,,NHLBI:126873;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"ALIOTTA, JASON M;",8196026;,5K08HL086868,01/04/2008,12/31/2012,"21+ years old; ATGN; Acute Pulmonary Injury; Adipogenesis Inhibitory Factor; Adult; Antigens; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basal segment of lung; Base of the Lung; Biology; Blood Precursor Cell; Board Certification; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bone Marrow Transplant; Bone Marrow Transplantation; Cancer, Oncology; Cell Communication; Cell Cycle; Cell Division Cycle; Cell Interaction; Cell Lineage; Cell-to-Cell Interaction; Cells; Colony-Stimulating Factor 2 Alpha; Critical Care; DNA; Deoxyribonucleic Acid; Development; Differentiation Factor, B-Cell; Discipline; Educational process of instructing; Elastases; Environment; Eosinophil-Mast Cell Growth-Factor; Erythrocyte Burst-Promoting Factor; Fellowship; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; Future; Grafting, Bone Marrow; HOSP; HPGF; Hematology; Hematopoietic Cytokine; Hematopoietic stem cells; Hepatocyte-Stimulating Factor; Home; Home environment; Hospitals; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-11; IL-3; IL-3(H); IL-6; IL11; IL3 Protein; IL6 Protein; Interleukin 3 (Colony-Stimulating Factor, Multiple); Interleukin 3 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin-11; Interleukin-3; Interleukin-6; Knowledge; Label; Laboratories; Lung; Lung Injury, Acute; Lung diseases; MCGF; MGF Stem Cell Factor; MGI-2; MULTI-CSF; Mammals, Mice; Marrow; Marrow Transplantation; Mast Cell Growth Factor; Mast-Cell Colony-Stimulating Factor; Mast-Cell Growth Factor; Medical Specialities; Medicine; Mentors; Mice; Modification; Mother Cells; Multilineage-Colony-Stimulating Factor; Multipotential Colony-Stimulating Factor; Murine; Mus; Myeloid Differentiation-Inducing Protein; P-CSF; P-Cell Stimulating Factor; Phenotype; Physicians; Plasmacytoma Growth Factor; Population; Postdoc; Postdoctoral Fellow; Progenitor Cells; Progenitor Cells, Hematopoietic; Program Development; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Pulmonary Diseases; Pulmonary Disorder; Radiation; Research; Research Associate; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory physiology; Rhodamine; Rhodamines; Rhode Island; Schools, Medical; Science of Medicine; Scientist; Sortings, Fluorescence-Activated Cell; Specialties, Medical; Specialty; Staining method; Stainings; Stains; Steel Factor; Stem Cell Factor; Stem cells; Teaching; Training; Training Programs; Universities; acute lung injury; adult human (21+); base; c-kit Ligand; career; communication aid; cytokine; effective therapy; gene product; hematopoietic growth factor; immunogen; improved; injured; interferon beta 2; kit Ligand; lung basal segment; lung disorder; lung function; lung injury; medical schools; medical specialties; new therapeutics; next generation therapeutics; novel therapeutics; oncology; post-doc; post-doctoral; programs; pulmonary; ray (radiation); repair; repaired; respiratory function; restoration; skills; stem cell biology; uptake",Injured Lung and its Influence on Bone Marrow Cell Phenotype,,86868,ZHL1,Special Emphasis Panel,,3,126873,
7758756,K08,HL,5,,02/01/2010,01/31/2011,PA-00-003,5K08HL087009-04,,NHLBI:126225;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MCGAFFIN, KENNETH ROBERT;",8554119;,5K08HL087009,02/01/2007,01/31/2012,"21+ years old; Adipose tissue; Adult; Advisory Committees; Aging; American Heart Association; Apoptosis; Apoptosis Pathway; Area; B-Cell Differentiation Factor Gene; B-Cell Stimulatory Factor 2 Gene; BSF-2 Gene; BSF2 Gene; Biochemical; Biochemistry; Blood Pressure, High; Blood Serum; Blood Volume; Body Tissues; Calories; Cardiac; Cardiac Failure Congestive; Cardiac Myocytes; Cardiac Output; Cardiac infarction; Cardiocyte; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Catheters; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Chemistry, Biological; Collaborations; Congestive Heart Failure; Data; Development; Dysfunction; Eating; Echocardiogram; Echocardiography; Endocrine Glands; Endocrine Organs; Endocrinology; Energy Expenditure; Energy Metabolism; Environment; Exhibits; Fats; Fatty Tissue; Fatty acid glycerol esters; Fellowship; Food Intake; Functional disorder; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; HSF Gene; Health; Heart; Heart Decompensation; Heart Failure, Congestive; Heart Hypertrophy; Heart failure; Heart myocyte; Hepatocyte Stimulatory Factor Gene; Histopathology; HuB219; Human, Adult; Hybridoma Growth Factor Gene; Hypertension; Hypothalamic structure; Hypothalamus; Hypoxia; Hypoxic; IFNB2 Gene; IL-1; IL-6 Gene; IL1; IL6; IL6 gene; INFLM; Inflammation; Inflammation Mediators; Inflammatory; Injury; Institutes; Interferon, Beta-2 Gene; Interleukin 6 (Interferon, Beta 2) Gene; Interleukin I; Interleukin-1; Interleukin-6 Gene; Intracellular Communication and Signaling; Investigation; Investigators; LEP-R; LEPR; LEPR Protein; Lead; Leptin; Leptin deficiency; Link; Lung; Lymphocyte-Stimulating Hormone; MMPs; Macrophage Cell Factor; Mammals, Mice; Matrix Metalloproteinases; Mediating; Medical; Mentors; Metabolic; Metabolism and Endocrinology; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Molecular; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocytes, Cardiac; Necrosis; Necrotic; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Organ System, Cardiovascular; Outcome; Over weight; Overweight; Oxidative Stress; Oxygen Deficiency; Pathology; Pathway interactions; Pb element; Physicians; Physiology; Physiopathology; Play; Pressure; Pressure- physical agent; Principal Investigator; Process; Production; Program Development; Programs (PT); Programs [Publication Type]; Research; Research Personnel; Researchers; Resolution; Resource Sharing; Respiratory System, Lung; Risk Factors; Role; Scientist; Senescence; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Structure; Students; T Helper Factor; TBARs; Task Forces; Techniques; Technology; Testing; Thiobarbituric Acid Reactive Substances; Tissues; Training; Training Programs; Transgenic Mice; Transthoracic Echocardiography; United States; Universities; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Virus; Viruses, General; Weight; Wild Type Mouse; abstracting; adipose; adiposity; adult human (21+); base; biological signal transduction; calorie (nutrition); cardiac failure; cardiac hypertrophy; cardiac infarct; cardiomyocyte; cardiovascular disorder; cardiovascular injury; career; circulatory system; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cytokine; db/db mouse; design; designing; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; heart attack; heart function; heart infarct; heart infarction; heart output; heart sonography; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; hypothalamic; improved; insight; leptin receptor; leptin-binding protein; lymphocyte activating factor; modifiable risk; ob/ob mouse; obese; obese people; obese person; obese population; pathophysiology; pathway; pressure; professor; programs; pulmonary; response; senescent; skills; social role; sound measurement; stressor; white adipose tissue; yellow adipose tissue",Impact of Leptin of Heart Failure and Survival after Myocardial Infarction,,87009,ZHL1,Special Emphasis Panel,,4,126225,
7764775,K08,HL,5,,02/01/2010,01/31/2011,PA-00-003,5K08HL087026-04,,NHLBI:140400;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,PEDIATRICS,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"MARTINEZ, JULIAN ANTONIO;",1905740;,5K08HL087026,02/05/2007,01/31/2012,"Animal Model; Animal Models and Related Studies; Antimorphic mutation; Basic Research; Basic Science; Biology; Blood (Leukemia); Blood Cells; Blood Precursor Cell; Body Tissues; Bone Marrow; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Growth and Maintenance; Cell Maintenance; Cell Process; Cell Signaling; Cell Transplantation; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Data; Defect; Development; Developmental Biology; Diagnosis; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drosophila; Drosophila genus; Drosophila melanogaster; Educational process of instructing; Fruit Fly, Drosophila; Generations; Genetic; Genetic Condition; Genetic Determinism; Genetic Diseases; Genetic Models; Genetic Screening; Goals; Hematopoietic; Hematopoietic stem cells; Hemocytes; Hereditary Disease; Immune; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Intracellular Communication and Signaling; Investigators; Larva; Leukemias, General; Lymph node proper; Maintenance; Maintenances; Medical; Mentors; Metabolic; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Genetic; Molecular Disease; Molecular Genetic; Molecular Genetics; Mother Cells; Natural regeneration; Organ; P element; Pathway interactions; Patients; Peripheral Blood Cell; Phosphorus; Population; Position; Positioning Attribute; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Regeneration; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Lymph Node; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Subcellular Process; Syndrome; System; System, LOINC Axis 4; Teaching; Techniques; Therapeutic; Therapeutic Intervention; Tissues; Transplantation; Vertebrate Animals; Vertebrates; abstracting; biological signal transduction; career; career development; cell type; design; designing; expectation; fruit fly; genetic determinant; genetic disorder; graduate student; hereditary disorder; human disease; immunosuppressed patient; intervention therapy; leukemia; loss of function; lymph gland; lymph nodes; model organism; mutant; notch; notch protein; notch receptors; novel; pathway; programs; reconstitute; reconstitution; regenerate; self-renewal; social role; stem cell biology; stem cell differentiation; stem cell niche; transplant; vertebrata",An Emerging Model of a Hematopoietic Stem Cell Niche in Drosophila,,87026,ZHL1,Special Emphasis Panel,,4,140400,
7742652,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL087932-03,,NHLBI:124929;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MYERBURG, MICHAEL M;",8209425;,5K08HL087932,01/01/2008,12/31/2012,"Absorption; Airway Obstruction; Anabolism; Antiproteases; Apical; Arts; Aspiration, Respiratory; Biochemical; Biochemistry; Breathing; Bypass; CF airway; CF airway epithelia; CF patients; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell surface; Cells; Cessation of life; Chemistry, Biological; Chronic; Cilia; Cleaved cell; Cystic Fibrosis; Data; Death; Defense Mechanisms; Development; Disease; Disorder; ENaC; ENaC (epithelial Na+ channel); Electrophysiology; Electrophysiology (science); Endopeptidase Inhibitors; Epithelial; Epithelial Cells; Equilibrium; Esteroproteases; Goals; Human; Human, General; Hydrogen Oxide; In Vitro; Individual; Infection; Inhalation; Inhaling; Inspiration, Respiratory; Investigators; Ion Channels, Sodium; Ion Transport; Laboratories; Liquid substance; Lung; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Methods; Modeling; Movement; Mucociliary Clearance; Mucociliary Transport; Mucous body substance; Mucoviscidosis; Mucus; Na element; Nature; Neurophysiology / Electrophysiology; Occidental; PRSS8; PRSS8 protein, human; Particulate Matter; Pathogenesis; Pathway interactions; Pb clearance; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Physicians; Physiologic; Physiological; Process; Process of absorption; Proprostasin; Prostasin; Prostasin Preproprotein; Protease Antagonists; Protease Inhibitor; Proteases; Protein Cleavage; Proteinase Inhibitors; Proteinases; Proteolysis; Proteolytic Clipping; Proteolytic Enzymes; Proteolytic Processing; Proteolytic Regulation; Regulation; Regulation of Proteolysis; Research Personnel; Researchers; Respiratory Failure; Respiratory System, Lung; Role; Serine Protease-8; Sodium; Sodium Channel; Sodium Chloride; Sodium chloride (NaCl); Surface; System; System, LOINC Axis 4; TGN; Testing; Viscosity; Water; Work; absorption; airway epithelium; airway surface liquid; apical membrane; balance; balance function; biosynthesis; body movement; cleaved; cystic fibrosis airway; cystic fibrosis airway epithelia; cystic fibrosis patients; disease/disorder; driving force; epithelial Na+ channel; epithelial amiloride-sensitive sodium channel; fluid; human PRSS8 protein; improved; inspiration; lead clearance; liquid; mucous; nexin; novel; pathogen; pathway; patients with CF; patients with cystic fibrosis; premature; prevent; preventing; psychological defense mechanism; pulmonary; respiratory insufficiency/failure; salt; skills; social role; trans-Golgi Network; white race",Altered Proteolytic Processing of ENaC in the Pathogenesis of Cystic Fibrosis,,87932,ZHL1,Special Emphasis Panel,,3,124929,
7755376,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL090913-02,,NHLBI:136350;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"AVDALOVIC, MARK V;",8918572;,5K08HL090913,01/10/2009,12/31/2013,"Agonist; Allergens; Allergic; Allergic asthma; Allergic inflammation; Archives; Area; Asthma; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Blood Vessels; Body Tissues; Bronchial Asthma; Care, Health; Cell-Extracellular Matrix; Cell/Tissue, Immunohistochemistry; Characteristics; Chronic; Chronic lung disease; Clinical; Disease; Disorder; Doctor of Philosophy; ECM; Epithelial; Epithelial Cells; Epithelium; Esteroproteases; Expenditure; Extracellular Matrix; Extrinsic asthma; Funding; GFAC; Gene Expression; Gene Proteins; Gene Transcription; Genetic Transcription; Genetics, in situ Hybridization; Grant; Growth Agents; Growth Factor; Growth Factor Receptor Genes; Growth Factors, Proteins; Growth Substances; Healthcare; IHC; IL-4; IL4; IL4 Protein; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Luciferase; In Situ Hybridization; In Vitro; Incidence; Inflammation; Inflammation Mediators; Inflammatory; Interleukin-4; Interleukin-4 Precursor; Investigators; Link; Luciferases; Lymphocyte Stimulatory Factor 1; MCGF-2; Macaca mulatta; Mast Cell Growth Factor-2; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mentors; Mesenchymal; Modeling; Morbidity; Morbidity - disease rate; Muscle, Smooth, Vascular; Obstruction; Pathology; Patient Education; Patient Instruction; Patient Training; Patients; Peptidases; Peptide Hydrolases; Ph.D.; PhD; Phenotype; Play; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteases; Protein Gene Products; Proteinases; Proteins; Proteolytic Enzymes; Proto-Oncogene, Growth Factor Receptor; R01 Mechanism; R01 Program; RNA Expression; RPG; Receptor Protein; Regulation; Reporter; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Respiratory physiology; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Source; Symptoms; T-Cell Growth Factor 2; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Up-Regulation; VEGF Receptors; VEGFA; VEGFR; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Gene; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vascular remodeling; Vegf; Vegf gene; airway epithelium; airway remodeling; allergic airway disease; allergic airway epithelium inflammation; allergic airway inflammation; atopic asthma; cytokine; density; disease phenotype; disease/disorder; extrinsic allergic asthma; gene product; in situ Hybridization Staining Method; language translation; laser capture microdissection; lung function; neovascularization; non-human primate; nonhuman primate; protein expression; receptor; respiratory function; social role; translation research enterprise; vascular",Airway Epithelium is Major Source of VEGF in Chronic Asthma,,90913,ZHL1,Special Emphasis Panel,,2,136350,
7754082,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL092298-02,,NHLBI:120726;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"BARISH, GRANT D;",7906159;,5K08HL092298,01/01/2009,12/31/2013,"A Mouse; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Activator Protein-1; Address; Agonist; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; B-Cell CLL/Lymphoma-6 Gene; B-Cell Lymphoma 6 Protein; B-cell CLL/Lymphoma-6; BCL5; BCL5 protein; BCL6; BCL6 Protein; BCL6 gene; Biochemical; Blood Vessels; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; CHIP assay; Cause of Death; Cell model; Cell surface; Cells; Cellular model; ChIP (chromatin immunoprecipitation); Chronic; Communicating Junction; Complex; Cys-His2 Zinc Finger Transcription Factor; Cys-His2 Zinc Finger Transcription Factor Gene; Cytokine Receptors; Cytokines, Chemotactic; Data; Development; Disease; Disorder; Drugs; Dysfunction; Engineering; Engineerings; Enhancer-Binding Protein AP1; Enzymes; Functional disorder; Gap Junctions; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Homologous Chemotactic Cytokines; IFN; INFLM; Immune; Immunoglobulin Enhancer-Binding Protein; In Vitro; Inflammation; Inflammatory; Instruction; Intercrines; Interferons; Intermediary Metabolism; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knockout Mice; LAZ-3 Gene; LAZ-3 Protein; LAZ3; Laboratories; Leiomyocyte; Lesion; Ligands; Lipids; Low-resistance Junction; Lymphoma-Associated Zinc Finger Gene on Chromosome 3; METBL; Macrophages, Peritoneal; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Murine; Mus; Mutation; Myocytes, Smooth Muscle; N-CoR protein; NCoR protein; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nexus; Nexus Junction; Nuclear Factor kappa B; Nuclear Receptor Corepressor; Nuclear Receptors; Nuclear Transcription Factor NF-kB; Null Mouse; Nutrition; Nutritional Science; PPAR; Pathway interactions; Peritoneal Macrophages; Peroxisome Proliferator-Activated Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiopathology; Profilings, Gene Expression; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RIP13 protein; RNA Expression; Receptor Protein; Receptors, Cytokine; Regulation; Repression; Reticuloendothelial System, Bone Marrow; Role; SIS cytokines; Science of nutrition; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; System; System, LOINC Axis 4; TLR4; TLR4 gene; TOLL; Testing; Therapeutic Effect; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription Activation; Transcription Factor AP-1; Transcription Factor NF-kB; Transcription, Genetic; Transcriptional Activation; Transplantation; United States; Up-Regulation; Work; ZNF51; ZNF51 Gene; Zinc Finger Protein 51; Zinc Finger Protein 51 Gene; atherogenesis; atheromatosis; atherosclerotic vascular disease; base; bcl-6 protein; bone; cell transduction; cell type; cellular transduction; chemoattractant cytokine; chemokine; chromatin immunoprecipitation; cofactor; cytokine; design; designing; disease/disorder; drug/agent; experiment; experimental research; experimental study; gene product; genome mutation; hToll; improved; in vivo; insight; kappa B Enhancer Binding Protein; knock-down; macrophage; mouse model; new therapeutics; next generation; next generation therapeutics; novel; novel therapeutics; nuclear factor kappa beta; nuclear receptor co-repressor; nutrition; pathophysiology; pathway; progenitor; protein complex; proto-oncogene protein bcl-6; receptor; receptor binding; research study; retroviral transduction; social role; transduced cells; transplant; vascular",Repressor-PPAR Interactions in Inflammation and Atherosclerosis,,92298,ZHL1,Special Emphasis Panel,,2,120726,
7758183,K08,HL,5,,01/01/2010,12/31/2010,PA-06-512,5K08HL094375-02,,NHLBI:137160;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"MORA, SAMIA ;",2056879;,5K08HL094375,01/15/2009,12/31/2012,"21+ years old; Adult; Affect; American; Apolipoproteins; Blood Banks; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Classification; Clinical Trials; Clinical Trials, Unspecified; Competence; Data; Detection; Development Plans; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Endocrine Therapy; Enrollment; Epidemiology; Event; Female Health; Forecast of outcome; Funding; Goals; Guidelines; HDL; HOSP; Heavy Lipoproteins; High Density Lipoproteins; High density lipoprotein; Hormonal Therapy; Hospitals; Human, Adult; Hyperlipemia; Hyperlipidemia; Immunoassay; Individual; Infrastructure; Instruction; International; Investigation; Investigators; Jupiter; K-Awards; K-Series Research Career Programs; LDL; LDL Cholesterol; LDL Cholesterol Lipoproteins; Leadership; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Low Density Lipoprotein Cholesterol; Low-Density Lipoproteins; MODY; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Medicine; Mentors; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Magnetic Resonance; Obesity; Organ System, Cardiovascular; Over weight; Overweight; PBO; Particle Size; Patients; Placebos; Plans, Development; Population; Prebeta-Lipoproteins; Predictive Value; Prevalence; Prevention Guidelines; Prevention Research; Prevention strategy; Preventive; Preventive strategy; Primary Prevention; Principal Investigator; Prognosis; Prospective Studies; Public Health; Public Health Schools; Randomized; Randomized Clinical Trials; Research; Research Career Program; Research Career Programs, K-Series; Research Design; Research Infrastructure; Research Personnel; Research Proposals; Researchers; Risk; Risk Assessment; Risk Factors; Risk Reduction; Role; Schools, Medical; Schools, Public Health; Science of Medicine; Sham Treatment; Specialist; Study Type; Systematics; T2D; T2DM; Testing; Thesaurismosis; Time; Training; Trials, Randomized Clinical; Type 2 diabetes; Type II diabetes; VLDL; Vascular, Heart; Very low density lipoprotein; Woman; Women's Health; adiposity; adult human (21+); adult onset diabetes; alpha-Lipoproteins; base; beta-Lipoprotein Cholesterol; beta-Lipoproteins; cardiac disease prevention; cardiovascular disease prevention; cardiovascular disease risk; cardiovascular disease therapy; cardiovascular disorder; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular disorder therapy; cardiovascular risk; cardiovascular risk factor; career; career development; circulatory system; clinical investigation; clinical practice; corpulence; corpulency; corpulentia; cost; design; designing; diabetes risk; disease/disorder; double-blind placebo controlled trial; double-masked controlled study; double-masked controlled trial; effective therapy; enroll; experience; hormone therapy; improved; ketosis resistant diabetes; maturity onset diabetes; medical schools; men; men's; metabolism disorder; novel; obese; obese people; obese person; obese population; outcome forecast; particle; professor; prospective; public health medicine (field); randomisation; randomization; randomly assigned; sham therapy; skills; social role; study design","Novel Lipoproteins, Cardiometabolic Risk, and Statin Therapy",,94375,ZHL1,Special Emphasis Panel,,2,137160,
7743090,K08,HL,5,,12/01/2009,11/30/2010,PA-06-512,5K08HL094759-02,,NHLBI:127440;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"WEST, TIMOTHY EOIN;",8057727;,5K08HL094759,12/01/2008,11/30/2013,"(11)Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-; Adaptor Protein; Adaptor Signaling Protein; Address; Advisory Committees; Aerosols; Alveolar Macrophages; Antibiotic Therapy; Antibiotic Treatment; Antibodies, Blocking; Antibody Formation; Antibody Production; Antibody Response; Aspiration, Respiratory; B. pseudomallei; Bacteria; Bacterial Infections; Bacterial Pneumonia; Biology; Blocking Antibodies; Blood Serum; Blotting, Western; Bone Marrow; Breathing; Burkholderia pseudomallei; CDC; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase-1; Categories; Cause of Death; Cell Communication and Signaling; Cell Death; Cell Signaling; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Collaborations; Communicable Diseases; Complex; Curriculum; Cytochalasin D; Cytotoxic cell; Dendritic Cells; Dendritic cell activation; Development; Development Plans; Disease; Disease model; Disorder; Dose; EC 3.4.22.36; Educational Curriculum; Environment; Enzymes; Epithelial Cells; Flagellata; Flagellin; Gamma Globulin, 19S; Gamma Globulin, 7S; Genes; Goals; Health; Histopathology; Host Defense; Host Defense Mechanism; Host resistance; ICE Protease; IFN-gamma-Inducing Factor; IGIF; IL-1; IL-1 Gamma; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-18; IL-18 receptor; IL-1b Converting Enzyme; IL-1g; IL1; IL1 Receptors; IL18 Protein; IL1B-Convertase; IL1BC; IL1F4; IgG; IgM; Immune; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin G; Immunoglobulin M; Immunologist; Immunology; Immunology (Including BRMP); Immunology (NCI Program); In Situ Nick-End Labeling; In Vitro; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammatory Response; Inhalation; Inhaling; Inspiration, Respiratory; Instruction; Interferon-gamma-Inducing Factor; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin I; Interleukin-1; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1 Gamma; Interleukin-1 Receptors; Interleukin-18; Interleukin-18 Precursor; Interleukin-1beta Converting Enzyme; Intracellular Communication and Signaling; Investigation; Investigators; K lymphocyte; Knockout Mice; Knowledge; LPS; Laboratories; Lead; Ligands; Lipopolysaccharides; Lung; Lymphocyte-Stimulating Hormone; Lytotoxicity; MGC12320; Macromolecular Protein Complexes; Macrophage Cell Factor; Macrophages, Alveolar; Mammals, Mice; Mastigophora; Measures; Mediating; Melioidosis; Mentorship; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mission; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiprotein Complexes; Murine; Mus; NIH; NK Cells; National Institutes of Health; National Institutes of Health (U.S.); Natural Immunity; Natural Killer Cells; Nuclear; Nuclear Translocation; Null Mouse; P. pseudomallei; P.pseudomallei; P45; Pathologist; Pathway interactions; Pb element; Phenotype; Plans, Development; Pneumonia; Pneumonia, Bacterial; Pneumonitis; Population; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Pseudomonas pseudomallei; Public Health; Pulmonary Inflammation; Pulmonary Macrophages; Receptor Protein; Receptor Signaling; Receptors, IL-1; Receptors, Interleukin-1; Research; Research Personnel; Research Resources; Researchers; Resources; Respiratory Infections; Respiratory System, Lung; Respiratory Tract Infections; Reticuloendothelial System, Bone Marrow; Role; Scientist; Sepsis; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Splenocyte; T Helper Factor; TIL3; TIL4; TLR protein; TLR2; TLR2 gene; TLR4; TLR4 gene; TLR5; TLR5 gene; TOLL; TUNEL; TUNEL Assay; Task Forces; TdT-Mediated dUTP Nick End Labeling Assay; Testing; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Training; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Universities; Veiled Cells; Washington; Western Blotting; Western Blottings; Western Immunoblotting; aerosolized; antibody biosynthesis; bacterial disease; bacterial genetics; biological signal transduction; bloodstream infection; burden of disease; burden of illness; career; career development; conference; cytokine; cytosolic receptor; cytotoxicity; disability; disease burden; disease/disorder; disorder model; flagellate; hToll; heavy metal Pb; heavy metal lead; host response; immunoglobulin biosynthesis; immunoresponse; inspiration; interleukin-18 receptor; laboratory facility; lymphocyte activating factor; macrophage; multidisciplinary; necrocytosis; new therapeutics; next generation therapeutics; novel therapeutics; pathogen; pathway; programs; protein blotting; public health medicine (field); pulmonary; receptor; response; sensor; skills; social role; symposium; terminal nick end labeling; translational study; treatment of bacterial diseases; treatment of bacterial infectious disease; uptake; years of life lost to disability; years of life lost to disease",Pulmonary Pathogen-Recognition Pathways in Melioidosis,,94759,ZHL1,Special Emphasis Panel,,2,127440,
7766218,K08,HS,5,,02/01/2010,01/31/2011,PA-00-010,5K08HS015699-05,,AHRQ:;,2010,AGENCY FOR HEALTHCARE RESEARCH AND QUALITY,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"ALEXANDER, G CALEB;",8147312;,5K08HS015699,02/08/2006,01/31/2011,,An RCT To Decrease Out-Of-Pocket Prescription Costs,,15699,HCRT,HSR Health Care Research Training SS,,5,122850,
7755385,K08,MH,5,,02/01/2010,01/31/2011,PA-06-512,5K08MH079033-03,,NIMH:177301;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"SUBLETTE, M ELIZABETH ;",8691637;,5K08MH079033,04/01/2008,01/31/2013,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Affect; Affective Disorders; Affective Psychosis, Bipolar; Arachidonic Acids; Bipolar Disorder; Blood Plasma; Brain; Brain region; Cerebrum; Characteristics; Clinical; Complex; Controlled Study; D-Glucose; Data; Depressed mood; Depression; Depression and Suicide; Dextrose; Dietary Fatty Acid; Docosahexaenoate; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Emotional Depression; Encephalon; Encephalons; Enteramine; Exhibits; Fatty Acids; Fatty Acids, Omega-3; Fatty Acids, Polyunsaturated; Fish Oils; Glucose; Hippophaine; History; Impulsivity; Individual; Intake; Intermediary Metabolism; Investigators; Lipid Biochemistry; METBL; Major Depressive Disorder; Maps; Medical Imaging, Positron Emission Tomography; Membrane; Mental Depression; Metabolic; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods; Mood Disorders; Nervous System, Brain; Neurobiology; Nutritional; Oils; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Patients; Pattern; Phosphatides; Phospholipids; Pilot Projects; Plasma; Polyunsaturated Fatty Acids; Positron Emission Tomography Scan; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopic Imaging; Psychosis, Manic-Depressive; Public Health; Rad.-PET; Recording of previous events; Reporting; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; Science of Statistics; Seafood Oil; Serotonin; Serum, Plasma; Severities; Statistics; Suicide; Suicide attempt; Supplementation; Symptoms; Symptoms of depression; Testing; base; bipolar affective disorder; comparison group; depressed; depressive; depressive symptoms; design; designing; fatal attempt; fatal suicide; glucose metabolism; glucose uptake; healthy volunteer; improved; indexing; intent to die; interest; major depression; manic depressive disorder; manic depressive illness; membrane structure; n-3 Fatty Acids; neurobiological; neuroimaging; non fatal attempt; omega-3; pilot study; placebo controlled study; placebo controlled trial; polyunsaturated fatty acid; public health medicine (field); public health relevance; sadness; social role; standard care; statistics; suicidal attempt; suicidal risk; suicidality; suicide attempter; suicide risk",Neuroimaging of Fatty Acids in Major Depression,,79033,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,3,177301,
7755384,K08,MH,5,,02/01/2010,01/31/2011,PA-06-512,5K08MH080329-03,,NIMH:171513;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"CHO, RAYMOND Y;",8035688;,5K08MH080329,05/01/2008,01/31/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Accounting; Aminalon; Aminalone; Behavior; Behavioral; Brain; Butanoic acid, 4-amino-; Cognition; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complement; Complement Proteins; Computer Simulation; Computerized Models; Connector Neuron; Development; Disease; Disorder; Disturbance in cognition; EEG; Electroencephalography; Encephalon; Encephalons; Environment; Event; Exhibits; Functional Magnetic Resonance Imaging; GABA; Goals; Image; Impaired cognition; Impairment; In Vitro; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Lead; MRI, Functional; Magnetic Resonance Imaging, Functional; Maintenance; Maintenances; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Methods; Modeling; Models, Computer; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Patients; Pb element; Performance; Physiology; Process; Property; Property, LOINC Axis 2; Schizophrenia; Schizophrenic Disorders; Simulation, Computer based; Sound; Sound - physical agent; Stimulus; Study models; Symptoms; Synapses; Synaptic; Task Performances; Testing; Translating; Translatings; base; behavior measurement; behavioral measure; behavioral measurement; blood oxygen level dependent; cognitive control; cognitive dysfunction; cognitive loss; cognitively impaired; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; dementia praecox; disease/disorder; fMRI; functional outcomes; gamma-Aminobutyric Acid; heavy metal Pb; heavy metal lead; imaging; in silico; in vivo; insight; language translation; model development; neural; neural mechanism; neuromechanism; neuronal; new therapeutics; next generation therapeutics; novel; novel therapeutics; performance tests; relating to nervous system; response; schizophrenic; sound; stimulus processing; theories; virtual simulation",Computational and Neural Mechanisms of Context Processing in Schizophrenia,,80329,ZRG1,Special Emphasis Panel,,3,171513,
7772260,K08,NS,5,,02/01/2010,01/31/2011,PA-00-003,5K08NS048113-04,,NINDS:161784;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,NONE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"DRIBBEN, WILLIAM H;",7355652;,5K08NS048113,01/01/2006,01/31/2012,"5-Oxazolecarboxylic acid, 2-(6-(bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-; Absolute ethanol; Address; Age; Agonist; Alcohol, Ethyl; Ammon Horn; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Animals; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; BAX; BAX gene; BCL2-Associated X Protein Gene; BCL2L4; Biochemical Pathway; Blotting, Western; Brain; CAP4 protease; CASP-3; CASP3; CASP8 Protein; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Calcium Channel; Calcium Channel Antagonist Receptor; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase Inhibitor; Caspase-8/Flice; Cations, Divalent; Cell Culture Techniques; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cell-Death Protease; Cell/Tissue, Immunohistochemistry; Cells; Cellular Membrane; Cessation of life; Charge; Childhood; Clinical; Common Rat Strains; Cornu Ammonis; Culture Media; Cysteine Protease CPP32; Death; Development; Discipline of obstetrics; Divalent Cations; Dose; Drug usage; EAA Antagonists; ETOH; Eclampsia; Electron Microscopy; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Ethanol; Excitatory Amino Acid Antagonists; Exposure to; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Fetus; Fluorescent Probes; Foundations; Fura-2; Genes; Gestation; Gestosis, EPH; Glutamate Antagonists; Glutamate Receptor Antagonists; Grain Alcohol; Hippocampus; Hippocampus (Brain); Histological Technics; Histological Techniques; Human; Human, General; ICE-like protease; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Intervention; Intervention Strategies; Investigators; Ion Channel; Ion Channels, Calcium; Ionic Channels; Knockout Mice; Labor, Premature; Learning; MACH protein; Magnesium; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mch5 protease; Mediating; Medicine; Membrane; Membrane Channels; Metabolic Networks; Methods; Methods and Techniques; Methods, Other; Methylcarbinol; Mg element; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nature; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurochemistry; Neurocyte; Neuron Degeneration; Neuronal Injury; Neurons; Neurophysiology / Electrophysiology; Null Mouse; Obstetrics; PARP Cleavage Protease; Pathway interactions; Pattern; Perinatal Exposure; Pre-Eclampsia; Preeclampsia; Pregnancy; Premature Labor; Premature Obstetric Labor; Preterm Labor; Probes, Fluorescent; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Proteinuria-Edema-Hypertension Gestosis; Public Health; Rat; Rattus; Reaction; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, N-Methylaspartate; Research; Research Personnel; Researchers; Rodent; Rodentia; Rodentias; SCA-1; SREBP Cleavage Activity 1; Science of Medicine; Science of neurochemistry; Screening procedure; Series; Sodium Channel Blockers; Specificity; Statistical Methods; Supervision; Surface; Technics, Histologic; Techniques; Techniques, Histologic; Testing; Time; Toxemias, Pregnancy; Toxicokinetics; Transgenic Animals; VDCC; Voltage-Dependent Calcium Channels; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; Work; Yama; Yama protein; caspase; caspase-3; caspase-8; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; drug use; experiment; experimental research; experimental study; fetal; fetal exposure; gene product; growth media; hippocampal; imaging; in utero exposure; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; interventional strategy; intra-uterine environmental exposure; intrauterine environmental exposure; magfura-2; membrane structure; necrocytosis; neural degeneration; neurochemistry; neurodegeneration; neuron injury; neuron toxicity; neuronal; neuronal degeneration; neuronal toxicity; neuroprotection; neurotoxic; neurotoxicity; neurotrophic factor; neurotrophin; neutrophin; pathway; pediatric; pregnancy toxemia/hypertension; prevent; preventing; programs; protein blotting; public health medicine (field); receptor; research study; response; screening; screenings; sedative; synapse formation; synaptogenesis",Magnesium Induced Developmental Neuroapoptosis,,48113,NST,Training Grant and Career Development Review Committee,,4,161784,
7768371,K08,NS,5,,03/01/2010,02/28/2011,PA-00-003,5K08NS050654-05,,NINDS:173799;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,ANESTHESIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"ANGELOTTI, TIMOTHY P;",1908825;,5K08NS050654,03/01/2006,02/28/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; ADRGND; Abbreviations; Academic Training; Address; Adenoviridae; Adenoviruses; Adrenal Glands; Adrenals; Adrenergic Receptor; Adrenoceptors; Advisory Committees; Affinity; Agonist; Amino Acid Motifs; Anesthesiology; Assay; Autonomic nervous system; Autoreceptors; Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Cannabinoids; Cardiac Failure Congestive; Catecholamines; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chemistry, Biological; Chimera Protein; Chimeric Proteins; Chromaffin Cells; Clinical; Congestive Heart Failure; Coupling; Critical Care; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Development; Disease; Disorder; Doctor of Philosophy; Drugs; Dysautonomias; Dysfunction; EC 2.7; Electrodes; Endoplasmic Reticulum; Ergastoplasm; Evolution; Exhibits; Feedback; Fellowship; Functional disorder; Fusion Protein; G Protein-Complex Receptor; G Protein-Coupled Receptor Genes; G-Protein-Coupled Receptors; G-Proteins; GPCR; GPR; GRK; GTP-Binding Proteins; GTP-Regulatory Proteins; Genetic; Genetic Polymorphism; Genotype; Germany; Glia; Glial Cells; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heart Decompensation; Heart Failure, Congestive; IRK1 channel; Idiopathic Parkinson Disease; Immune Precipitation; Immunoprecipitation; Individual; Infection; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigation; Investigators; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; K+ Channels, Inwardly Rectifying; Kinases; Knock-out; Knockout; Knockout Mice; Knowledge; Kolliker's reticulum; Lead; Levarterenol; Levonorepinephrine; Lewy Body Parkinson Disease; Link; Linkage (Genetics); Measures; Mediating; Medication; Medicine; Metabotropic Glutamate Receptors; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Molecular; Morbidity; Morbidity - disease rate; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System Diseases; Nervous System Physiology; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurologic function; Neurological Disorders; Neurological function; Neuromodulator; Neurons; Neurotransmitters; Non-neuronal cell; Noradrenaline; Norepinephrine; Null Mouse; Odor Receptor Protein; Odorant Receptors; Olfactory Receptor Proteins; Opiates; Organ; Pain; Painful; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patient Care; Patient Care Delivery; Patients; Pb element; Peripheral Nervous System; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Phenotype; Phosphotransferases; Physiologic; Physiological; Physiology; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Postdoc; Postdoctoral Fellow; Potassium Channels, Inwardly Rectifying; Primary Parkinsonism; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding Domain; Protein Binding Motif; Protein Motifs; Protein-Protein Interaction Domain; Proteins; RT-PCR; RTPCR; Receptor Cell; Receptor Protein; Receptor Proteins, Odorant; Receptors, Epinephrine; Receptors, Metabotropic Glutamate; Receptors, Odorant; Recombinants; Regulation; Research; Research Associate; Research Personnel; Researchers; Residencies; Reverse Transcriptase Polymerase Chain Reaction; Role; SNS; Science of Medicine; Scientist; Second Messenger Systems; Second Messengers; Sepsis; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Sympathetic Ganglia; Sympathetic Nervous System; Sympathins; System; System, LOINC Axis 4; Task Forces; Techniques; Testing; Training; Training Programs; Training, Academic; Transfection; Transgenic Organisms; Transphosphorylases; Universities; Variant; Variation; adenoreceptor; biological signal transduction; bloodstream infection; cannabinoid receptor; carbon felt; carbon fiber; career; cell type; chronic pain; chronic painful condition; cultured cell line; disease/disorder; drug/agent; gene product; genetic linkage; genetic variant; heavy metal Pb; heavy metal lead; insight; inward rectifier potassium channel; molecular array; nerve cement; nervous system disorder; nervous system function; neural; neurological disease; neuronal; neurotransmitter release; pathophysiology; polymorphism; post-doc; post-doctoral; programs; protein structure; receptor; relating to nervous system; response; reverse transcriptase PCR; second messenger; skills; social role; success; suprarenal gland; trafficking; transgenic",Sympathetic Neuron alpha2 Adrenoceptor Structure/Function,,50654,NST,Training Grant and Career Development Review Committee,,5,173799,
7758770,K08,NS,5,,02/01/2010,01/31/2011,PA-00-003,5K08NS053651-05,,NINDS:170166;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"HUH, JIMMY WOOK;",8252201;,5K08NS053651,03/06/2006,01/31/2011,"0-11 years old; 2-Hydroxy-N,N,N-trimethylethanaminium; Accident and Emergency department; Acetyl-CoA[{..}]choline O-acetyltransferase; Acute; Advisory Committees; Age; Ammon Horn; Animals; Atrophic; Atrophy; Attenuated; Behavioral; Body Tissues; Bone structure of cranium; Brain; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cerebrospinal Fluid; Cerebrum; Cessation of life; Child; Child Care; Child Youth; Childhood; Children (0-21); Choline; Choline Acetylase; Choline Acetyltransferase; Choline O-Acetyltransferase; Chronic; Closed head injuries; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Common Rat Strains; Cornu Ammonis; Cranium; Critical Care; DAI; Death; Desminase; Development; Devices; Diffuse; Diffuse Axonal Injury; Disturbance in cognition; Dysfunction; Emergency Department; Emergency room; Encephalon; Encephalons; Environment; Esteroproteases; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Exhibits; Functional disorder; Future; Generalized Growth; Goals; Growth; Head; Head Injuries, Nonpenetrating; Head Trauma, Closed; Hippocampus; Hippocampus (Brain); Histologic; Histologically; Hospitals, Pediatric; Human; Human Resources; Human, Child; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Impaired cognition; Injury; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intensive Care Units; Intracranial Pressure; Investigation; Investigators; Laboratories; Learning; Left; Liquid substance; Mammals, Rats; Man (Taxonomy); Man, Modern; Manpower; Medial; Mediating; Medicine; Mentors; Metabolic; Method LOINC Axis 6; Methodology; Modeling; Mortality; Mortality Vital Statistics; Nerve Cells; Nerve Degeneration; Nerve Growth Factors; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuron Degeneration; Neuronal Differentiation; Neuronotrophic Factors; Neurons; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Only Child; P38 Membrane Protein, Synaptic Vesicle; Papain-Like Cysteine Protease; Pathologic; Pediatric Brain Injury; Pediatric Hospitals; Pennsylvania; Peptidases; Peptide Hydrolases; Philadelphia; Physicians; Physiopathology; Process; Programs (PT); Programs [Publication Type]; Proteases; Protein P38, Synaptic Vesicle; Proteinases; Proteolytic Enzymes; Public Health; Puericulture; Rat; Rattus; Recovery; Research; Research Design; Research Personnel; Research Proposals; Research Resources; Researchers; Resources; Schools, Medical; Science of Medicine; Scientist; Silicones; Skull; Somatomedin C; Study Type; Subarachnoid Pressure; Subcellular Process; Supportive Therapy; Supportive care; Synapses; Synaptic; Synaptophysin; Task Forces; Testing; Tissue Growth; Tissues; Training; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Universities; Writing; authority; axon growth; axonal growth; brain atrophy; cerebral atrophy; children; clinical relevance; clinically relevant; cognitive dysfunction; cognitive loss; cognitively impaired; college; cortical atrophy; cranium; disability; effective therapy; enhancing factor; fluid; hippocampal; immunoreactivity; improved; injured; intervention design; liquid; medical schools; neural degeneration; neurodegeneration; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neurotrophic factor; neurotrophin; neutrophin; novel; ontogeny; pathophysiology; pediatric; personnel; prevent; preventing; programs; public health medicine (field); pup; skills; spinal fluid; study design; synapse formation; synaptogenesis; therapy design; traumatic brain damage; treatment design; youngster",Neurotrophin Treatment for Pediatric Brain Injury,,53651,NST,Training Grant and Career Development Review Committee,,5,170166,
7763880,K08,NS,5,,02/01/2010,01/31/2011,PA-06-512,5K08NS057824-03,,NINDS:177012;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"SEDLAK, THOMAS WILLIAM;",8827923;,5K08NS057824,02/01/2008,01/31/2012,"21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-; Aging; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Animals; Antioxidants; Apoptosis; Apoptosis Pathway; Bilirubin; Bilirubin IX alpha; Bilirubin, total; Biliverdin reductase; Binding; Binding (Molecular Function); Biology; Blood Coagulation Factor IV; Blood Serum; Brain; Brain Diseases; Brain Disorders; Brain Vascular Disorders; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Care, Health; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Protection; Cell Signaling; Cell model; Cells; Cellular model; Cerebrovascular Disease; Cerebrovascular Disorders; Clinical; Clinical Research; Clinical Study; Coagulation Factor IV; Cornu Ammonis; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cysteine; Cytoprotectants; Cytoprotection; Cytoprotective Agent; Cytoprotective Drugs; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development Plans; Disease; Disorder; Doctor of Medicine; Doctor of Philosophy; Dysfunction; Encephalon; Encephalon Diseases; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enzymes; Exhibits; Factor IV; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Functional disorder; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; HO-2 protein; Half-Cystine; Healthcare; Heme; Heme b; Hippocampus; Hippocampus (Brain); Human; Human, General; Hydrogen Oxide; Idiopathic Parkinson Disease; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Intracranial Vascular Disorders; Knowledge; L-Cysteine; Lewy Body Parkinson Disease; Link; Lipids; M.D.; Major Depressive Disorder; Man (Taxonomy); Man, Modern; Mentors; Metabolic; Methods and Techniques; Methods, Other; Modeling; Molecular Interaction; Molecular Target; Mononitrogen Monoxide; NOS 1 protein; Nerve Cells; Nerve Degeneration; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neural Growth; Neurocyte; Neuron Degeneration; Neuronal Growth; Neuronal Transmission; Neurons; Neurosciences; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Outcome; Oxidative Stress; Oxygenases; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Ph.D.; PhD; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Physiopathology; Plans, Development; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Primary Parkinsonism; Primary Senile Degenerative Dementia; Production; Proteins; Protoheme; Protoheme IX; Psychiatry; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Resistance; Role; Schools, Medical; Scientist; Senescence; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Susceptibility; Techniques; Training; Vascular Diseases, Intracranial; Water; Work; anti-oxidant; bilirubin NAD(P) oxidoreductase; biological signal transduction; career; career development; cellular targeting; dementia of the Alzheimer type; disease/disorder; endothelial cell derived relaxing factor; ferroheme; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; heme oxygenase-2; hippocampal; improved; intervention design; knockout animal; major depression; medical schools; molecular imaging; nNOS enzyme; necrocytosis; neural; neural degeneration; neurodegeneration; neurogenesis; neuronal; neuronal degeneration; neuronal nitric oxide synthase; neuropsychiatric; neuropsychiatry; neurotransmission; oxidation; pathophysiology; pathway; primary degenerative dementia; professor; protein protein interaction; relating to nervous system; resilience; resistant; senescent; senile dementia of the Alzheimer type; social role; therapy design; treatment design",Cell signaling and cytoprotective roles of biliverdin reductase,,57824,NST,Training Grant and Career Development Review Committee,,3,177012,
7751899,K08,NS,5,,02/01/2010,01/31/2011,PA-06-512,5K08NS058674-03,,NINDS:173340;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROSURGERY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"EID, TORE ;",6808540;,5K08NS058674,02/01/2008,01/31/2013,"Acquired brain injury; Ammon Horn; Animal Model; Animal Models and Related Studies; Area; Arts; Assay; Astrocytes; Astrocytus; Astroglia; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain Injuries; CHIP assay; Causality; ChIP (chromatin immunoprecipitation); Chromatin; Common Rat Strains; Cornu Ammonis; Coupled; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug resistance; Dysfunction; Encephalon; Encephalons; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Etiology; Functional disorder; Gene Expression; Genes; Genetic Techniques; Genetics, in situ Hybridization; Gln; Glutamate Ammonia Ligase (ADP); Glutamate-Ammonia Ligase; Glutamates; Glutamine; Glutamine Synthetase; Goals; Hippocampus; Hippocampus (Brain); Histone Deacetylation; Human; Human, General; In Situ Hybridization; Intervention; Intervention Strategies; Knowledge; L-Glutamate; L-Glutamate[{..}]ammonia ligase (ADP-forming); L-Glutamine; Ligase; Mammals, Rats; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Messenger RNA; Methods and Techniques; Methods, Other; Modeling; Molecular Genetic; Molecular Genetics; Molecular Interaction; Nervous System, Brain; Patients; Photometry/Spectrum Analysis, Mass; Physiopathology; Proteins; Proteomics; Q. Levoglutamide; RNA, Messenger; Rat; Rattus; Recurrence; Recurrent; Research Specimen; Resected; Role; Seizure Disorder; Seizures; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Synthetases; Technics, Genetic; Techniques; Temporal Lobe Epilepsy; Testing; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; abstracting; brain damage; brain lesion (from injury); brain tissue; chromatin immunoprecipitation; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug resistant; epilepsia; epileptiform; epileptogenic; extracellular; gel electrophoresis; gene product; glutamate synthetase; glutamine synthase; hippocampal; in situ Hybridization Staining Method; interventional strategy; mRNA; mRNA Expression; model organism; novel; pathophysiology; prevent; preventing; resistance to Drug; resistant to Drug; social role; transcription factor",Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy,,58674,NST,Training Grant and Career Development Review Committee,,3,173340,
7766979,K22,AI,5,,02/01/2010,01/31/2011,PAR-07-347,5K22AI073781-02,,NIAID:108000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LATHEM, WYNDHAM W.;",7798013;,5K22AI073781,02/09/2009,01/31/2011,"A Mouse; Address; Aerosols; Affect; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Aspiration, Respiratory; Bacillus; Bacillus (bacterium); Bacterial Genes; Biological Terrorism; Bioterrorism; Breathing; Categories; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complement; Complement Proteins; Cytosol; Differential Gene Expression; Disease; Disease Progression; Disorder; Environment; Future; Gene Deletion; Gene Expression; Genes; Genes, Bacterial; Goals; Grant; Hour; Human; Human, General; INFLM; Immune response; Immunity; In Vitro; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Inhalation; Inhaling; Inspiration, Respiratory; Investigators; Lung; Man (Taxonomy); Man, Modern; Methods; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nature; Outcome; Pasteurella pestis; Pathogenesis; Pattern; Phagocytosis; Phase; Plague; Plasmids; Pneumonic Plague; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Public Health; Relative; Relative (related person); Research Personnel; Researchers; Respiratory Infections; Respiratory System, Lung; Respiratory Tract Infections; Role; Route; Subcellular Process; Syndrome; System; System, LOINC Axis 4; Testing; Time; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Type III Secretion System; Type III Secretion System Pathway; Virulence; Virulent; Work; Y. pestis; Y.pestis; Yersinia; Yersinia pestis; Yersinia pestis disease; base; design; designing; disease/disorder; gene deletion mutation; gene product; host response; immunoresponse; inspiration; mouse model; mutant; prevent; preventing; programs; public health medicine (field); pulmonary; pulmonary function; social role; tissue culture; vaccine development",Global and temporal effects of virulence gene expression during pneumonic plague,,73781,ZAI1,Special Emphasis Panel,,2,108000,
7764790,K22,AI,5,,02/01/2010,01/31/2011,PAR-07-347,5K22AI074909-02,,NIAID:108000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOLOGY,08,049435266,US,MA,02215,BOSTON UNIVERSITY,"FRYDMAN, HORACIO M;",8798661;,5K22AI074909,02/05/2009,01/31/2011,"Address; Arthropoda; Arthropods; Assay; Bacteria; Bioassay; Biologic Assays; Biological; Biological Assay; Body Tissues; Bone Morphogenetic Proteins; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Drosophila; Drosophila genus; Drosophila melanogaster; Ecology; Ensure; Environmental Science; Erinaceidae; Evolution; Flies; Fruit Fly, Drosophila; Gametogenesis; Generations; Genetic; Genital System, Female, Ovary; Germ Lines; Goals; Hedgehogs; Host Factor; Host Factor Protein; Infection; Injection of therapeutic agent; Injections; Insecta; Insects; Integration Host Factors; Intracellular Communication and Signaling; Invertebrata; Invertebrates; Invertebrates, General; Invertebrates, Insects; Investigation; Investigators; Kinetic; Kinetics; Maintenance; Maintenances; Molecular; Molecular Genetic; Molecular Genetics; Mother Cells; Ocular Onchocerciasis; Onchocerciasis, Ocular; Oogenesis; Ovarian; Ovary; Parasites; Parasitic Diseases; Phenotype; Pressure; Pressure- physical agent; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Reproductive system; Research; Research Personnel; Researchers; River Blindness; Route; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Stem cells; Subcellular Process; System; System, LOINC Axis 4; Tissues; Transmission; Transplantation; Tropism; Vertical Disease Transmission; Vertical Transmission; Wolbachia; Work; biological signal transduction; disease control; disorder control; egg; fly; fruit fly; human disease; mother to child transmission; pathogen; pressure; programs; stem cell niche; tool; transmission process; transplant",Host-pathogen interactions in targeting Wolbachia to the stem cell niche,,74909,MID,Microbiology and Infectious Diseases Research Committee,,2,108000,
7772293,K22,AI,5,,02/01/2010,01/31/2011,PAR-07-347,5K22AI077507-02,,NIAID:107200;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,PEDIATRICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"MOORE, MARTIN LAWRENCE;",6425313;,5K22AI077507,02/20/2009,01/31/2011,"Affect; Air; Airway Hyper-responsiveness; Airway Obstruction; BALB/c; BALB/cJ Mouse; BPTP3; Basic Research; Basic Science; Biomedical Research; Bronchiolitis; CD8; CD8B; CD8B1; CD8B1 gene; CFC; Candidate Disease Gene; Candidate Gene; Cells; Chromosome Mapping; Clinic; Clinical; Comparative Study; D12S1644; Data; Dependence; Disease; Disorder; Doctor of Philosophy; Dysfunction; Environment; Fellowship; Fibrin; Functional disorder; Future; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetics, Gene Mapping; Genome; Genotype; Goals; HOSP; Histopathology; Hospitalization; Hypoxia; Hypoxic; IL-13; IL-4-STAT; IL13; Immunologic, Immunochemical; Immunologics; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Inbred BALB C Mice; Infant; Infection; Institution; Interleukin-13; Investigators; LYT3; Laboratories; Lead; Linkage Mapping; Lung; Mammals, Mice; Maps; Mechanical ventilation; Mediator; Mediator of Activation; Mediator of activation protein; Mentors; Mice; Mice, Inbred BALB C; Modeling; Molecular; Mouse, BALB C; Mucous body substance; Mucus; Murine; Mus; Mutagenesis, Site-Directed; NS1; Nucleotide Mapping; Nucleotides; Obstruction; Oxygen Deficiency; PTP-1D; PTP2C; PTPN11; PTPN11 gene; Pathogenesis; Pathogenicity; Pb element; Ph.D.; PhD; Physiopathology; Pneumonia, Viral; Position; Positioning Attribute; Production; Productivity; Programs (PT); Programs [Publication Type]; Reporting; Research; Research Personnel; Researchers; Respiratory Syncytial Virus Infections; Respiratory System, Lung; Respiratory syncytial virus; Role; SH-PTP2; SH-PTP3; SHP-2; SHP2; STAT6; STAT6 gene; STAT6B; STAT6C; Severity of illness; Site-Directed Mutagenesis; Site-Specific Mutagenesis; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Targeted DNA Modification; Targeted Modification; Testing; Thymus-Dependent Lymphocytes; Training; Training and Education; Translating; Translatings; Vaccines; Viral; Viral Diseases; Viral Genetics; Viral Pathogenesis; Viral Pneumonia; Virulence; Virus Diseases; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; base; cell type; constriction; cytokine; disease severity; disease/disorder; genetic mapping; heavy metal Pb; heavy metal lead; improved; in vivo; insight; language translation; mechanical respiratory assist; mouse model; mucous; novel; pathophysiology; positional cloning; professor; programs; pulmonary; respiratory; reverse genetics; social role; thymus derived lymphocyte; viral infection; virus genetics; virus infection; virus pathogenesis","Mechanisms of Respiratory Syncytial Virus-Induced Mucus"" Viral Strain Dependence",,77507,MID,Microbiology and Infectious Diseases Research Committee,,2,107200,
7772324,K22,AI,5,,02/01/2010,01/31/2011,PAR-07-347,5K22AI078757-02,,NIAID:108000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MAYWOOD,UNITED STATES,ANATOMY/CELL BIOLOGY,04,791277940,US,IL,60153,LOYOLA UNIVERSITY CHICAGO,"CAMPBELL, EDWARD M;",9040854;,5K22AI078757,02/18/2009,01/31/2011,"AIDS Virus; Affect; Biochemical; Capsid; Capsid Proteins; Cells; Coat Proteins; Cytoplasm; Development; Endocytosis; Event; Frequencies (time pattern); Frequency; Friend virus susceptibility 1; Fv-1 protein; Fv1; Fv1 protein; Genetic Alteration; Genetic Change; Genetic defect; HIV-1; HIV-I; HIV1; HSPC062; Human; Human immunodeficiency virus 1; Human, General; Immunodeficiency Virus Type 1, Human; In Situ; Individual; Infection; Infection prevention; Label; Language; Lead; Life Cycle; Life Cycle Stages; Macaca mulatta; Mammals, Primates; Man (Taxonomy); Man, Modern; Methods; Methods and Techniques; Methods, Other; Microscopy; Molecular Biology Techniques; Monitor; Mouse Leukemia Viruses; Murine leukemia virus; Mutation; Nature; Pb element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Prevent infection; Primates; Process; Proteins; Research; Retroviridae; Retroviridae Infections; Retroviridae disease; Retrovirus Infections; Retroviruses; Rhesus; Rhesus Macaque; Rhesus Monkey; System; System, LOINC Axis 4; T-Cell Receptor Interacting Molecule Gene; TRIM; TRIM Gene; Techniques; Viral; Viral Coat Proteins; Viral Diseases; Viral Outer Coat Protein; Virion; Virus; Virus Diseases; Virus Particle; Virus-Retrovirus; Viruses, General; Work; coat (nonenveloped virus); design; designing; gene product; genome mutation; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; life course; mutant; prevent; preventing; tool; viral infection; virus infection",Analysis of restriction factor function in situ,,78757,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,2,108000,
7764668,K22,AI,5,,02/01/2010,01/31/2011,PAR-07-347,5K22AI079409-02,,NIAID:108000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,DERMATOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"FORD, MANDY L.;",8090133;,5K22AI079409,02/04/2009,01/31/2011,"ATGN; Adverse effects; Affect; Antigens; Autoimmune; Autoimmune Diabetes; Autoimmune Process; Biological Models; Bp50; CD154; CD28; CD28 gene; CD40; CD40L; CD40LG; CD8; CD8B; CD8B1; CD8B1 gene; CDW40; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chronic; Clinical, Transplantation, Organ; Co-Stimulator; Costimulator; Death; Dermatoplasties; Dermatoplasty; Development; Disease; Disorder; Drugs; Engraftment; Epidermal Thymocyte Activating Factor; Exhibits; Exposure to; Goals; Graft Material; Graft Rejection; Graft Survival; Grafting Procedure; IL-2; IL2; IL2 Protein; Immune response; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; LCM Viruses; LCMV; LYT3; Lead; Lymphocyte Mitogenic Factor; Lymphocytic choriomeningitis virus; MGC9013; Maintenance; Maintenances; Mammals, Mice; Medication; Methods and Techniques; Methods, Other; Mice; Mitogenic Factor; Model System; Modeling; Models, Biologic; Murine; Mus; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Programs (PT); Programs [Publication Type]; Receptor Protein; Research; Research Personnel; Researchers; Seminal; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Transplantation; Skin graft; Staging; Stimulus; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T44; TNFRSF5; TNFRSF5 gene; TNFSF5; TNFSF5 gene; TRAP Gene; Techniques; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation Surgery; Transplanted tissue; Treatment Side Effects; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Variant; Variation; Viral; Viral Burden; Viral Diseases; Viral Load; Viral Load result; Virus; Virus Diseases; Viruses, General; Work; allogenic skin graft; allograft rejection; base; biological signal transduction; cytokine; density; deprivation; disease/disorder; drug/agent; exhaustion; fitness; grafting, skin; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; improved; insight; loss of function; mouse model; organ allograft; organ graft; organ xenograft; p50; pathway; prevent; preventing; programs; receptor; response; side effect; surgery; therapy adverse effect; thymus derived lymphocyte; transplant; treatment adverse effect; viral infection; virus infection",Antigen Density Critically Impacts T Cell Programming During Transplantation,,79409,AITC,"Allergy, Immunology, and Transplantation Research Committee",,2,108000,
7758254,K23,AI,5,,02/01/2010,01/31/2011,,5K23AI065806-02,,NIAID:125028;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"DUBBERKE, ERIK R;",7588918;,5K23AI065806,02/01/2009,01/31/2012,"Advisory Committees; Allogenic; Antibiotic Resistance; Antibodies; Blood Precursor Cell; Blood Serum; C. difficile; C.difficile; Care, Health; Clinical; Clostridium difficile; Cohort Studies; Colony Stimulating Factor 3; Concurrent Studies; Development; Diarrhea; Disease; Disorder; Environment; Environmental Pollution; Epidemiology; Ethics; Faculty; GVHD; General Population; General Public; Graft-Versus-Host Disease; Graft-vs-Host Disease; Granulocyte Colony-Stimulating Factor; HSC transplantation; Hand; Health Care Providers; Health Personnel; Healthcare; Healthcare Providers; Healthcare worker; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Homologous Wasting Disease; Hospital Infections; Hospital acquired infection; Immunity; Infection; Instruction; Investigators; Knowledge; Length of Stay; Limulus factor C; Master of Science; Mentors; Morbidity; Morbidity - disease rate; Multivariate Analyses; Multivariate Analysis; Nosocomial Infections; Number of Days in Hospital; Outcome; Pathogenesis; Patients; Pluripoietin; Population Study; Prevention; Process; Progenitor Cell Transplantation; Progenitor Cells, Hematopoietic; Public Health; Publishing; Relative; Relative (related person); Research; Research Design; Research Personnel; Research Proposals; Research Resources; Researchers; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resources; Risk; Risk Factors; Runt Disease; Sample Size; Serum; Stem Cell Transplantation; Stem cell transplant; Study Type; Task Forces; Time; Toxin; Training; Transmission; Transplant Recipients; antibiotic resistant; career development; cost; disease/disorder; environmental contaminant; environmental contamination; factor C; granulocyte colony stimulating factor; health care personnel; health care worker; health provider; healthcare personnel; high risk; horseshoe crab factor C; hospital days; hospital length of stay; hospital stay; immunosuppressed; institutional infection; medical personnel; pathogen; patient centered; patient oriented; patient population; prevent; preventing; prospective; public health medicine (field); study design; transmission process; transplant patient; treatment provider",C. DIFFICILE DISEASE IN STEM CELL TRANSPLANT RECIPIENTS,,65806,MID,Microbiology and Infectious Diseases Research Committee,,2,125028,
7776881,K23,AI,5,,03/01/2010,02/28/2011,PA-00-004,5K23AI068458-05,,NIAID:133920;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BASSETT, INGRID VALERIE;",8040182;,5K23AI068458,03/01/2006,02/28/2011,"AIDS; AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV prevention; AIDS/HIV test; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Africa South of the Sahara; African; American; Area; Availability of Health Services; Bears; Blood Plasma; Blood Serum; Care, Health; Caring; Clinic; Clinical; Clinical Investigator; Collaborations; Communicable Diseases; Counseling; Counselor; Country; Critical Care; Diagnosis; Early Diagnosis; Early identification; Epidemic; Epidemiology; Fostering; Foundations; Gene Products, RNA; Goals; Government; HIV; HIV Infections; HIV Prevention; HIV diagnosis; HIV test; HIV/AIDS prevention; HOSP; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Health Benefit; Health Services Accessibility; Healthcare; Hospitals; Hospitals, City; Hospitals, Metropolitan; Hospitals, Urban; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Immunologic Deficiency Syndrome, Acquired; Improve Access; Incidence; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inpatients; International; Intervention; Intervention Strategies; Investigators; LAV-HTLV-III; Link; Lymphadenopathy-Associated Virus; Medical; Mentors; Mentorship; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH Office of AIDS Research; Newly Diagnosed; Out-patients; Outcome; Outcomes Research; Outpatients; PROV; Patients; Plasma; Prevalence; Prevention Research; Prevention strategy; Preventive strategy; Professional counselor; Programs (PT); Programs [Publication Type]; Province; Public Health Schools; RNA; RNA, Non-Polyadenylated; RNA, Viral; Records; Republic of South Africa; Research; Research Personnel; Research, Outcomes; Researchers; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Schools, Public Health; Scientist; Screening procedure; Secondary Prevention; Serum; Serum, Plasma; Services; Site; South Africa; Sputum; Staging; Stigmata; Sub-Saharan Africa; Subsaharan Africa; Symptoms; T-Lymphotropic Virus Type III Infections, Human; Testing; Tuberculosis; Union of South Africa; Urban Hospitals; Ursidae; Ursidae Family; Virus-HIV; Work; access to services; access to treatment; antiretroviral therapy; availability of services; base; case finding; cohort; disseminated TB; disseminated tuberculosis; early detection; experience; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; improved; innovate; innovation; innovative; interventional strategy; programs; rapid detection; screening; screenings; skills; social stigma; stigma; tuberculous spondyloarthropathy; uptake; viral RNA; virus RNA; ward","The Efficacy and Impact of Routine HIV and TB Testing in Durban, South Africa",,68458,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,5,133920,
7762164,K23,AI,5,,02/01/2010,01/31/2011,PA-00-004,5K23AI073190-03,,NIAID:130410;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"CHARLES, MACARTHUR ;",1874081;,5K23AI073190,02/15/2008,01/31/2013,"2',3'-Dideoxy-3'-thiacytidine; 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-; 21+ years old; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 3TC; 6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; AIDS Virus; AIDS test; AIDS/HIV test; AZT; AZT (Antiviral); Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Adult; Anti-Retroviral Agents; Antiretroviral Agents; Antiretroviral drug resistance; Azidothymidine; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blood Plasma; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ Cell Counts; CD4+ Counts; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cancers; Caring; Cell Count; Cell Number; Cells; Cells, CD4; Cessation of life; Clinic; Clinical; Collection; Control Groups; Data; Death; Developing Countries; Developing Nations; Development; Diagnosis; Diagnostic Findings; Drops; Drug resistance; Drug resistant viral; Drug usage; Drugs; EFV; Enrollment; Equipment; FLR; Failure (biologic function); Freezing; Gene Products, RNA; General Population; General Public; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Guidelines; HIV; HIV test; HIV-1; HIV-1 drug resistance; HIV-1 drug resistant; HIV-I; HIV1; HIV1 drug resistance; HIV1 drug resistant; HTLV-III; Haiti; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human immunodeficiency virus test; Human, Adult; Immunodeficiency Virus Type 1, Human; Immunologic, Immunochemical; Immunologics; Individual; Infant; Infrastructure; Investigators; LAV-HTLV-III; Laboratories; Laboratory Personnel; Lamivudine; Less-Developed Countries; Less-Developed Nations; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Medication; Mentors; Monitor; Monitoring, Patient; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mothers; Mutation; Opportunistic Infections; Patient Monitoring; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; RNA; RNA, Non-Polyadenylated; Recruitment Activity; Regimen; Research; Research Infrastructure; Research Personnel; Research Resources; Research Specimen; Researchers; Resistance; Resistance profile; Resistant profile; Resources; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Risk; Sampling; Serologic tests; Serological Tests; Serum, Plasma; Signs and Symptoms; Specimen; T4 Cells; T4 Lymphocyte Count; T4 Lymphocytes; Testing; Third-World Countries; Third-World Nations; Thymidine, 3'-azido-3'-deoxy-; Time; Training; Transmission; Treatment Failure; Under-Developed Countries; Under-Developed Nations; United States; Universities; Viral; Viral Burden; Viral Load; Viral Load result; Virus-HIV; Visit; ZDV; Zidovudine; adult human (21+); anti-retroviral; anti-retroviral drug resistance; anti-retroviral drug resistant; antiretroviral; antiretroviral drug resistant; antiretroviral therapy; azidodeoxythymidine; base; clinical epidemiology; cohort; drug resistant; drug resistant virus; drug use; drug/agent; efavirenz; enroll; failure; follow-up; genome mutation; helper T cell; human T cell leukemia virus III; human T lymphotropic virus III; intervention development; laboratory facility; malignancy; neoplasm/cancer; recruit; resistance mutation; resistance to Drug; resistance to HIV-1 drug; resistance to HIV1 drug; resistance to anti-retroviral drug; resistance to antiretroviral drug; resistant; resistant to Drug; resistant to HIV-1 drug; resistant to HIV1 drug; resistant to anti-retroviral drug; resistant to antiretroviral drug; response; serology; standard of care; statistics/biometry; therapy development; time interval; transmission process; treatment development; trend; volunteer",Monitoring Response to ARV Therapy and Development of HIV-1 Drug Resistance,,73190,ZAI1,Special Emphasis Panel,,3,130410,
7759508,K23,AI,5,,02/01/2010,01/31/2011,PA-05-143,5K23AI078755-02,,NIAID:135135;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BRONX,UNITED STATES,EMERGENCY MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"COWAN, ETHAN ADRIAN;",9208512;,5K23AI078755,01/20/2009,12/31/2013,"21+ years old; AIDS Virus; AIDS test; AIDS/HIV test; Accident and Emergency department; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adoption; Adult; Attitude; Belief; Bioethics; CDC; Care, Health; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Counseling; Curriculum; Data; Development; Educational Curriculum; Elements; Emergency Department; Emergency Medicine; Emergency room; Empirical Research; Environment; Epidemic; Ethicists; Ethics; Ethics Consultants; Ethics, Biomedical; Exercise; Exercise, Physical; Faculty; Goals; Guidelines; HIV; HIV test; HTLV-III; Happiness; Happinesses; Head; Healthcare; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Human, Adult; Individual; Informed Consent; International; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; LAV-HTLV-III; Language; Lead; Lymphadenopathy-Associated Virus; Medical; Medical center; Medicine; Mentors; Methodology, Research; Methods; Monitor; NIH; National Institutes of Health; National Institutes of Health (U.S.); PROV; Patient Care; Patient Care Delivery; Patients; Pb element; Population; Prevention Guidelines; Primary Care; Primary Health Care; Primary Healthcare; Procedures; Process; Programs (PT); Programs [Publication Type]; Provider; Public Health; Public Health Practice; Recommendation; Research; Research Career Program; Research Career Programs, K-Series; Research Methodology; Research Methods; Research Personnel; Researchers; Rights; Science; Science of Medicine; Site; Testing; Training; Uninsured; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Universities; Virus-HIV; adult human (21+); base; clinical care; clinical investigation; college; experience; heavy metal Pb; heavy metal lead; instrument; positive attitude; professor; programs; public health medicine (field); safety net; scale up; treatment center",The Ethics of Opt-Out Provider-Initiated HIV Testing in the Emergency Department,,78755,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,2,135135,
7770882,K23,AI,5,,03/01/2010,02/28/2011,PA-05-143,5K23AI079401-02,,NIAID:137160;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,PEDIATRICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"BLASCHKE-BONKOWSKY, ANNE J.;",8807968;,5K23AI079401,03/01/2009,02/28/2013,"0-11 years old; 0-6 weeks old; 21+ years old; Academia; Address; Adult; Analysis, Decision; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotic susceptibility; Antibiotic-resistant organism; Antibiotics; Antimicrobial Resistance; Antimicrobial resistant; Assay; Attitude; Bioassay; Biologic Assays; Biological Assay; Biotechnology; Birth; Blood; Blood Sample; Blood specimen; Care, Health; Cause of Death; Cerebrospinal Fluid; Cessation of life; Child; Child Youth; Child, Hospitalized; Children (0-21); Cities; Clinical; Clinical Research; Clinical Study; Collaborations; Data; Death; Decision Analyses; Decision Analysis; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Future; Genes; Genetic Determinism; Genotype; Goals; HOSP; Health Care Research; Health Services Evaluation; Health Services Research; Healthcare; Healthcare Research; Hospital Infections; Hospital acquired infection; Hospitalized Child; Hospitals; Hour; Human, Adult; Human, Child; IT Systems; Idaho; Immunity; Incidence; Industry; Infant; Infant, Newborn; Infant, Premature; Infection; Infectious Agent; Information Systems; Information Technology Systems; Instruction; Intensive Care Units, Neonatal; Investigators; Knowledge; Lactamase; Lead; Leadership; Learning; Length; Medical; Medical Care Research; Methods; Miscellaneous Antibiotic; Modeling; Molecular; Neonatal; Neonatal Intensive Care Units; Nested PCR; Nested Polymerase Chain Reaction; Newborn Infant; Newborn Intensive Care Units; Newborns; Nosocomial Infections; Nucleic Acids; Observational Study; Organism; Outcome; Parturition; Pathogen detection; Patient Care; Patient Care Delivery; Patients; Pb element; Performance; Physicians; Population; Position; Positioning Attribute; Predictive Value; Premature Infant; Preparation; Procedures; Programs (PT); Programs [Publication Type]; Reporting; Research; Research Personnel; Research Specimen; Researchers; Resistance; Resistance to antibiotics; Resistance to antimicrobial; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Blood; Sampling; Scientist; Sensitivity and Specificity; Sepsis; Severities; Sodium Chloride; Sodium chloride (NaCl); Specimen; Sterility; Survey Instrument; Surveys; Symptoms; System; System, LOINC Axis 4; Systems, Data; Technology; Testing; Time; Training; Universities; Utah; Validation; Vancomycin; WHBLOOD; Whole Blood; adult human (21+); anti-microbial resistance; anti-microbial resistant; antibiotic resistant; base; bloodstream infection; career; career development; children; design; designing; enteric pathogen; genetic determinant; heavy metal Pb; heavy metal lead; high risk; improved; infectious organism; innovate; innovation; innovative; innovative technologies; institutional infection; instrument; interdisciplinary approach; living system; neonatal sepsis; neonate; new diagnostics; newborn human (0-6 weeks); next generation diagnostics; novel diagnostics; pathogen; patient oriented research; patient oriented study; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; programs; prospective; resistance to anti-microbial; resistant; resistant to anti-microbial; resistant to antimicrobial; salt; services research; skills; spinal fluid; sterile; youngster",Rapid Molecular Testing for Neonatal Antibiotic-Resistant Pathogens,,79401,MID,Microbiology and Infectious Diseases Research Committee,,2,137160,
7760937,K23,AI,5,,02/01/2010,01/31/2011,PA-05-143,5K23AI081540-02,,NIAID:124200;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"HARTIGAN-O'CONNOR, DENNIS J;",1883014;,5K23AI081540,02/01/2009,01/31/2014,"21+ years old; AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adult; Affect; Age; Ak-Tate; Animals; Anti-Viral Response; Antigenic Specificity; Antigens; Antiviral Response; Area; Articulose-50; Autoimmune Diseases; Award; Balpred; Blood; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; California; Cells; Cells, CD4; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cohort Studies; Communicable Diseases; Complex; Concurrent Studies; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Deltacortilen; Deltastab; Development; Development Plans; Diopred; Disease; Disease Frequency Surveys; Disease Progression; Disorder; Doctor of Philosophy; Econopred; Equilibrium; FLR; Failure (biologic function); Feasibility Studies; Fetus; Funding; General Hospitals; Generations; Goals; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hexacortone; Hospitals, General; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, General; Hydrocortancyl; Immune; Immune Tolerance; Immune response; Immunologic Tolerance; Immunologic, Immunochemical; Immunologics; Impairment; Individual; Inf-Oph; Infant; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflanefran; Investigators; K23 Award; K23 Mechanism; K23 Program; Key-Pred; LAV-HTLV-III; LYT3; Leadership; Link; Locaseptil-Neo; Longitudinal Studies; Lymphadenopathy-Associated Virus; Macaca; Macaque; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Mice; Modeling; Mothers; Murine; Mus; Ophtho-Tate; Patients; Pattern; Ph.D.; PhD; Plans, Development; Play; Postdoc; Postdoctoral Fellow; Pred Fort; Pred Forte; Pred Mild; Predaject; Predalone; Predate; Predcor; Prednefrin SF; Predni-H; Predni-POS; Prednihexal; Predniocil; Property; Property, LOINC Axis 2; Public Health; Publishing; R01 Mechanism; R01 Program; RPG; Regulation; Regulatory T-Lymphocyte; Research; Research Associate; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Reticuloendothelial System, Blood; Role; SIV; Sampling; San Francisco; Science of Medicine; Shapes; Simian Immunodeficiency Viruses; Solutions; Specificity; Specificity, Antigenic; Stimulus; Study Type; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Testing; Therapy, Vaccine; Thymus-Dependent Lymphocytes; Time; Tissue Sample; Training; Universities; VAC-TX; Vaccine Therapy; Virus; Virus-HIV; Viruses, General; adult human (21+); autoimmune disorder; balance; balance function; career; career development; clinical investigation; cohort; design; designing; disease/disorder; experience; experiment; experimental research; experimental study; failure; fetal; helper T cell; host response; immune system tolerance; immune unresponsiveness; immunogen; immunological paralysis; immunoresponse; in utero; long-term study; longitudinal analysis; non-human primate; nonhuman primate; post-doc; post-doctoral; prevent; preventing; public health medicine (field); research study; response; skills; social role; study design; thymus derived lymphocyte",Regulatory T cell influence on infant and adult immune responses to HIV,,81540,AIDS,Acquired Immunodeficiency Syndrome Research Review Committee,,2,124200,
7778386,K23,AI,5,,03/01/2010,02/28/2011,PA-05-143,5K23AI082553-02,,NIAID:131409;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"SANDISON, TAYLOR ;",8412987;,5K23AI082553,03/03/2009,02/28/2014,"0-11 years old; 2 year old; 3 year old; 4 year old; 5 year old; AIDS Virus; ATGN; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Africa; Africa South of the Sahara; African; Age; Age-Months; Anti-Malarials; Antibodies; Antifolates; Antigens; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Area; Attention; Award; Bactrim; Benefits and Risks; Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blood; Blood erythrocyte; Blood normocyte; Breast Feeding; Breastfeeding; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Case Management; Cell Surface Antigens; Centrin; Cessation of life; Chemoprevention; Chemoprophylaxis; Child; Child Youth; Children (0-21); Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cohort Studies; Communicable Diseases; Complex; Concurrent Studies; Contracting Opportunities; Contracts; Cotrim; Data; Death; Development; Disease; Disorder; Drugs; Enrollment; Epidemiology; Erythrocytes; Erythrocytic; Eslectin; Evaluation; Exposure to; Folate Analog; Folate Inhibitors; Folic Acid Analog; Folic Acid Antagonists; Folic Acid Inhibitors; Foundations; Funding; Future; Goals; Guidelines; HIV; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Child; Immune; Immunity; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Incidence; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Insecticides; Insozalin; International; Intervention; Intervention Strategies; Investigation; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; LAV-HTLV-III; Lead; Life; Literature; Liver; Logistics; Lymphadenopathy-Associated Virus; MSA-1; MSA-1 Protein; MSA1; MSA1 Protein; MSP-1; MSP1; Major Merozoite Surface Protein Precursor; Malaria; Marrow erythrocyte; Measurement; Measures; Medication; Mentors; Merozoite Surface Antigen 1; Merozoite Surface Protein 1; Methods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mothers; Opportunistic Infections; Outcome; PFM-PSCP; PMMSA; Paludism; Parasitemia; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmodium Infections; Plasmodium falciparum; Plasmodium falciparum Merozoite Precursor Surface Coat Protein; Play; Policies; Predisposition; Prevalence; Prevention; Prevention Measures; Principal Investigator; Prophylactic treatment; Prophylaxis; Randomized; Recommendation; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Career Program; Research Career Programs, K-Series; Research Design; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Risk; Role; Running; Rural; SMZ-TMP; Staging; Study Type; Sub-Saharan Africa; Subsaharan Africa; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Susceptibility; TMP-SMX; Testing; Time; Training; Transmission; Trimedin; Trimethoprim-Sulfamethoxazole; Trimethoprim-Sulfamethoxazole Combination; Trimezole; Uganda; Virus-HIV; WHO; World Health Organization; aged; biomarker; blood corpuscles; body system, hepatic; career; career development; children; circumsporozoite protein; clinical investigation; cohort; cost; cs protein; design; designing; disease/disorder; drug/agent; effective therapy; enroll; experience; five year old; folate antagonist; four year old; heavy metal Pb; heavy metal lead; immunogen; interest; interventional strategy; merozoite surface protein; organ system, hepatic; parasaetemia; prevent; preventing; protective efficacy; randomisation; randomization; randomly assigned; resistant; rural area; secondary outcome; skills; social role; statistics/biometry; study design; three year old; tool; transmission process; two year old; youngster",Rebound Malaria Following Trimethoprim-Sulfamethoxazole Prophylaxis in Children,,82553,MID,Microbiology and Infectious Diseases Research Committee,,2,131409,
7764662,K23,DA,5,,02/01/2010,01/31/2011,PA-05-143,5K23DA019914-03,,NIDA:156844;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SALT LAKE CITY,UNITED STATES,PSYCHOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"BURROW-SANCHEZ, JASON JESS;",8587049;,5K23DA019914,03/01/2008,01/31/2013,"21+ years old; AOD use; Accounting; Acculturation; Acculturations; Active Follow-up; Adherence; Adherence (attribute); Admission; Admission activity; Adolescent; Adolescent Youth; Adult; After Care; After-Treatment; Aftercare; Age; Age Group Unspecified; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; Area; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Research; Behavioral Therapy; Behavioral Treatment; Belief; Censuses; Client; Clinical; Cognitive; Competence; Conditioning Therapy; Coping Behavior; Coping Skills; Cultural Assimilation; Data; Dependence; Development Plans; Diagnosis; Drug usage; Drug user; Drugs, Illicit; Educational Mainstreaming; Elements; Empirical Research; Environment; EtOH drinking; Ethnic and Racial Minorities; Expectancy; Family; Future; Group Therapy; Health; Health Care Providers; Health Personnel; Health behavior; Healthcare Providers; Healthcare worker; Hispanic Populations; Hispanics; Hispanics or Latinos; Hops; Human, Adult; Humulus; Illicit Drugs; Immigrant; Indigenous Population; Individual; Investigators; K23 Award; K23 Mechanism; K23 Program; Knowledge; Latino Population; Lead; Learning; Life; Life Style Modification; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Measures; Mediation; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Method LOINC Axis 6; Methodology; Minority; Minority Groups; Modeling; Monitor; NIDA; National Institute of Drug Abuse; Native People; Native-Born; Negotiating; Negotiation; Out-patients; Outcome; Outpatients; Parents; Participant; Patient Self-Report; Pb element; Persons; Pilot Projects; Plans, Development; Population; Problem behavior; Process; Programs (PT); Programs [Publication Type]; Randomized; Randomized Clinical Trials; Relaxation; Reporting; Research; Research Personnel; Researchers; Resolution; Risk; Rosa; Rose; SAMHSA; Sampling; Scientist; Self Efficacy; Self-Report; Skills, Coping; Societies; Spanish Origin; Staging; Stress; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Substance abuse problem; Testing; Treatment outcome; Trials, Randomized Clinical; United States; United States Substance Abuse and Mental Health Services Administration; Urinary System, Urine; Urine; abuse of substances; adolescent substance use; adult human (21+); age group; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; behavior intervention; behavioral intervention; behavioral problem; career development; design; designing; drug use; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethnic minority; ethnic minority population; etoh use; expectation; experience; experiment; experimental research; experimental study; follow up assessment; follow-up; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; hispanic community; intervention design; juvenile; juvenile human; medical personnel; non-drug; patient centered; patient oriented; pilot study; programs; public health research; randomisation; randomization; randomly assigned; research study; satisfaction; skills; substance abuse; substance abuser; substance use; theories; therapy design; treatment design; treatment effect; treatment program; treatment provider; youth substance use",Efficacy of Group Treatment for Hispanic Adolescents,,19914,NIDA,Neuropharmacology Research Subcommittee,,3,156844,
7753838,K23,DA,5,,02/01/2010,01/31/2011,PA-05-143,5K23DA021225-03,,NIDA:156389;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PORTLAND,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"RIECKMANN, TRACI R;",7954999;,5K23DA021225,02/12/2008,01/31/2012,"Accountability; Accounting; Accreditation; Administrator; Adopted; Adoption; Alcohols; Arizona; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Budgets; California; Care, Health; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Certification; Characteristics; Chemical Class, Alcohol; Client; Client satisfaction; Clinical; Clinical Trials Network; Communities; Complex; Conditioning Therapy; Consultations; Corporate Culture; Cost Savings; Counselor; Data; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Dependence, Substance; Development; Diffusion; Dimensions; Disease; Disorder; Documentation; Drug abuse; Drugs; Education; Educational aspects; Elements; Evidence based practice; Evidence based treatment; Feedback; Focus Groups; Funding; Goals; Health Care Costs; Health Costs; Health Services; Healthcare; Healthcare Costs; Hour; Intervention; Intervention Strategies; Interview; Investigation; Investigators; K-Awards; K-Series Research Career Programs; Licensure; Life Style Modification; Longitudinal Studies; Manuals; Medication; Methods; Mission; Modeling; NIDA; NIH RFA; National Institute of Drug Abuse; New Mexico; Oregon; Organizational Culture; Out-patients; Outcome; Outpatients; PROV; Patient Satisfaction; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Policy Research; Professional counselor; Program Evaluation; Programs (PT); Programs [Publication Type]; Provider; Records; Regression Analyses; Regression Analysis; Regression Diagnostics; Relative; Relative (related person); Request for Applications; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Resolution; Sampling; Saving, Cost; Science; Services; Site; Site Visit; Statistical Regression; Structure; Substance Addiction; Substance abuse problem; Supervision; Survey Instrument; Surveys; System; System, LOINC Axis 4; Technology; Time; Training; Training and Education; Translations; Universities; Washington; Work; abuse of drugs; abuse of substances; abuses drugs; base; behavior intervention; behavioral intervention; career development; clinical data repository; clinical data warehouse; clinical practice; community based treatment; data repository; disease/disorder; drug/agent; effective intervention; health care service; improved; innovate; innovation; innovative; interventional strategy; long-term study; programs; relational database; skills; substance abuse; theories; tool; treatment center; treatment planning; treatment program; treatment strategy",Adoption of Evidence-Based Practices in Substance Abuse Treatment,,21225,NIDA,Neuropharmacology Research Subcommittee,,3,156389,
7751850,K23,DE,5,,02/01/2010,01/31/2011,PA-00-004,5K23DE015298-05,,NIDCR:135000;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,LEXINGTON,UNITED STATES,DENTISTRY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"DE LEEUW, RINSKJE ;",7355814;,5K23DE015298,02/01/2006,01/31/2011,"Aching muscles; Acute; Acute Pain; Address; Affect; Affective; Age; Age of Onset; Allergy; Analysis, Data; Anatomic; Anatomical Sciences; Anatomy; Animals; Anterior; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anxiety; Anxiolytic Agents; Anxiolytics; Area; Award; Awareness; Awarenesses; Behavioral; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blood Serum; Brain; Brain imaging; Brain region; Burn injury; Burning Mouth Syndrome; Burns; Cancers; Causality; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Cerebrum; Chronic; Clinical; Cognitive; Colitis, Mucous; Colon, Irritable; Complex; Cranial Nerve V; Data; Data Analyses; Dentistry; Diagnosis; Diffuse Myofascial Pain Syndrome; Distant; Doctor of Philosophy; Emotional; Encephalon; Encephalons; Endogenous Opiates; Environment; Epidemiology; Epileptiform Neuralgia; Estrogenic Agents; Estrogenic Compounds; Estrogens; Etiology; Exhibits; Face Pain; Facial Pain; Female; Female of child bearing age; Female of childbearing age; Fibromyalgia; Fibromyositis-Fibromyalgia Syndrome; Fibrositis; Fifth Cranial Nerve; Fothergill Disease; Fothergill's neuralgia; Functional Magnetic Resonance Imaging; Funding; Gonadal Steroid Hormones; Head and Neck; Head and neck structure; Headache, Migraine; Human; Human, General; Hyperalgesia; Hyperalgesic Sensations; Hypersensitivity; Incidence; Inferior Maxillary Bone; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Investigators; Irritable Bowel Syndrome; K23 Award; K23 Mechanism; K23 Program; Kentucky; Knowledge; Life; Limbic System; Location; MPD syndrome; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mandible; Masticatory muscles; Measures; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medicine; Menses; Menstruation; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Migraine; Modality; Monitor; Mouth Diseases; Muscle discomfort; Muscle of the Mastication; Muscle pain; Muscle pain/fibrositis; Muscle sorenesss; Musculoskeletal Diseases; Musculoskeletal Pain; Myalgia; Myalgia unspecified; Myalgic; Myodynia; Myoneuralgia; Myosalgia; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Nervus Trigeminus; Neural Cell; Neuraxis; Neurobiology; Neurocyte; Neurons; Nuclear Magnetic Resonance Imaging; Opioid; Oral Cavity Disease; Oral Cavity Disorder; Oral Disease; Oral Disorder; Oral health; Organism-Level Process; Organismal Process; Orofacial Pain; Outcome; Pain; Pain Centers; Pain Clinics; Pain Control; Pain Disorder; Pain Relief Units; Pain Research; Pain Therapy; Pain Threshold; Pain Tolerance Level; Pain management; Pain, Orofacial; Pain-Free; Painful; Participant; Pathology; Patients; Pattern; Perception; Peripheral; Personal Satisfaction; Persons; Ph.D.; PhD; Phase; Physiologic Processes; Physiological Processes; Play; Prefrontal Cortex; Pressure; Pressure- physical agent; Prevalence; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychology; Puberty; Recurrent pain; Reporting; Research; Research Design; Research Personnel; Researchers; Resistance; Rheumatism, Muscular; Role; Sample Size; Scanning; Science of Anatomy; Science of Medicine; Sensory; Serum; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somatosensory Cortex; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Stimulus; Stress; Structure; Study Type; System; System, LOINC Axis 4; TMJ Diseases; TMJ Disorders; TMJD; Temperature; Temporo-mandibular joint disorder; Temporomandibular Disorders; Temporomandibular Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular joint disorder; Testing; Thalamic structure; Thalamus; Therapeutic Estrogen; Tic Douloureux; Training; Training Programs; Tranquilizing Agents, Minor; Trifacial Neuralgia; Trigeminal Nerve; Trigeminal Neuralgia; Trigeminal Pain; Trigeminal System; Trigeminal nerve structure; Universities; Woman; Zeugmatography; anatomy; antianxiety agent; base; biological signal transduction; brain visualization; central pain; chronic neuropathic pain; chronic pain; chronic painful condition; cingulate cortex; cold temperature; college; cortical pain; dental health; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; endogenous opioid; experience; fMRI; fibromyalgia syndrome; gonadal steroids; health science research; human puberty; hyperalgia; interdisciplinary approach; interest; interventional strategy; low temperature; male; malignancy; mandibular; masticatory myalgia; masticatory myofascial pain; mechanical pressure; menstrual period; monthly period; mouth disorder; musculoskeletal disorder; myofascial pain dysfunction syndrome; neoplasm/cancer; neurobiological; neuroimaging; neuronal; oral facial pain; pain tolerance; pressure; professor; programs; reproductive; resistant; response; sex steroid; social role; somesthetic sensory cortex; spastic colon; statistics/biometry; study design; thalamic; trifocal neuralgia; trigeminal; volunteer; well-being; women of child bearing age; women of childbearing age",Central Pain Processing in Chronic Face Pain:fMRI Study,,15298,DSR,NIDR Special Grants Review Committee,,5,135000,
7761221,K23,DK,5,,02/01/2010,01/31/2011,PA-05-143,5K23DK073713-04,,NIDDK:129060;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"ROSEN, RACHEL L;",7726744;,5K23DK073713,02/01/2007,01/31/2012,"0-11 years old; 21+ years old; Accounting; Acids; Adult; Asthma; Award; Belief; Biochemistry, Manometry; Bronchial Asthma; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Causality; Child; Child Youth; Child health care; Childhood; Children (0-21); Chronic; Clinical Investigator; Clinical Research; Clinical Study; Cohort Studies; Concurrent Studies; Coughing; Data; Development; Diagnosis; Diagnostic tests; Disease; Disorder; Dose; Drugs; Electrical Impedance; Ensure; Epidemiology; Esophageal; Esophageal Reflux; Etiology; Evaluation; Faculty; Funding; GERD; Gastro-oesophageal Reflux; Gastroenterologist; Gastroenterology; Gastroesophageal Reflux; Gastroesophageal reflux disease; Goals; Grant; Head and Neck, Larynx; Health, Child; Human, Adult; Human, Child; Impedance; Instruction; K-Awards; K-Series Research Career Programs; Knowledge; Laryngeal; Larynx; Lead; Learning; Lipid-Laden Macrophage; Lung; Lung diseases; Manometry; Measures; Medication; Mentors; Mentorship; Methods; Modeling; Morbidity; Morbidity - disease rate; Oto/Rhino/Laryngology; Otolaryngology; Patients; Pb element; Pediatrics; Pepsin; Pepsin A; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiology; Pneumology; Pneumonology; Prevalence; Pulmonary Disease (Specialty); Pulmonary Diseases; Pulmonary Disorder; Pulmonary Medicine; Pulmonology; QOL; Quality of life; Reflux; Research; Research Career Program; Research Career Programs, K-Series; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Science of Statistics; Severities; Severity of illness; Social Welfare; Statistics; Stridors; Symptoms; Testing; Toxin; Trachea; Trachea Proper; Training; Training Activity; adult human (21+); airway epithelium infalmmation; airway inflammation; base; career; children; conference; disease causation; disease etiology; disease severity; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; electric impedance; experience; heavy metal Pb; heavy metal lead; improved; indexing; lung disorder; member; multidisciplinary; new technology; otorhinolaryngology; pediatric; pulmonary; respiratory; response; social role; statistics; symposium; tool; voice box; welfare; windpipe; youngster",Impact of non-acid reflux on respiratory diseases in children,,73713,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,4,129060,
7784451,K23,DK,5,,02/01/2010,01/31/2011,PA-05-143,5K23DK080145-03,,NIDDK:185544;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"SPELIOTES, ELIZABETH K;",2056792;,5K23DK080145,03/01/2008,01/31/2013,"Abdomen; Abdominal; Abdominal obesity; Adipose tissue; Age; Android fat distribution; Apoplexy; BMI percentile; BMI z-score; Basic Research; Basic Science; Biology; Blood Coagulation Factor IV; Blood Pressure, High; Body Weight decreased; Body mass index; Ca++ element; Calcium; Cardiac Failure Congestive; Cardiovascular Diseases; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Central obesity; Centripetal obesity; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chest; Clinical; Coagulation Factor IV; Communities; Congestive Heart Failure; Coronary; Coronary Disease; Coronary heart disease; Curriculum; Data; Deposit; Deposition; Development; Development Plans; Diabetes Mellitus; Disease; Disorder; Drugs; Dyslipidemias; Educational Curriculum; Epidemic; Epidemiology; Factor IV; Family; Fat body with thin limbs; Fats; Fatty Liver; Fatty Tissue; Fatty acid glycerol esters; Formosa; Framingham Heart Study; Future; Gastroenterology; General Hospitals; Genes; Genetic; Genetic Determinism; Genetics, Human; Genomics; Genotype; Goals; Grant; HUMPPARG; Heart Decompensation; Heart Failure, Congestive; Hepatic Cirrhosis; Hepatic Disorder; Hepatic Failure; Heritability; Hispanic Populations; Hispanics; Hispanics or Latinos; Histology; Hospitals, General; Human; Human Genetics; Human, General; Hyperlipemia; Hyperlipidemia; Hypertension; Impaired fasting glycaemia; Individual; Institutes; Latino Population; Lead; Learning; Liver; Liver Cirrhosis; Liver Failure; Liver Steatosis; Liver diseases; Man (Taxonomy); Man, Modern; Massachusetts; Measures; Medication; Mentors; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Methods; Methods and Techniques; Methods, Other; NAFLD; NASH; NR1C3; Non-alcoholic steatohepatitis; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Occidental; PPARG; PPARG gene; PPARG1; PPARG2; Pathway interactions; Patients; Pb element; Peripheral arterial disease; Pharmaceutic Preparations; Pharmaceutical Preparations; Plans, Development; Polymorphism, Single Base; Postdoc; Postdoctoral Fellow; Prevalence; Quetelet index; Republic of China; Research; Research Associate; Research Design; Research Proposals; Research Resources; Resources; Risk Factors; SNP; SNPs; Sampling; Scanning; Science of Statistics; Scientist; Single Nucleotide Polymorphism; Spanish Origin; Statistics; Stroke; Structure; Study Type; TCF-4; TCF4; TCF7L2; TCF7L2 gene; TOMO; Taiwan; Techniques; Testing; Texas; Thesaurismosis; Thorace; Thoracic; Thorax; Tomogram; Training; Truncal obesity; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Visceral; Weight Loss; Weight Reduction; adipose; adiposity; bariatric surgery; base; biopsy of liver; body system, hepatic; body weight loss; brain attack; burden of disease; burden of illness; cardiovascular disorder; career development; cerebral vascular accident; clinical significance; clinically significant; cohort; coronary disorder; corpulence; corpulency; corpulentia; diabetes; disease burden; disease risk; disease/disorder; disorder risk; drug/agent; excess adiposity in midsection; gastric banding; gastric bypass surgery; genetic determinant; genetic epidemiology; genetic variant; genome-wide; heavy metal Pb; heavy metal lead; hepatic steatosis; hepatopathy; hispanic community; hyperpiesia; hyperpiesis; hypertensive disease; impaired fasting glucose; implantable gastric stimulation banding; improved; interest; liver biopsy; liver disorder; liver imaging; liver scanning; male-type obesity; metabolism disorder; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; obesity surgery; organ system, hepatic; pathway; patient oriented research; patient oriented study; population based; post-doc; post-doctoral; sex; skills; statistics; stomach stapling; stroke; study design; subcutaneous; trunk obesity; visceral obesity; waist circumference; waist-predominant obesity; weight loss surgery; white adipose tissue; white race; wt-loss; years of life lost to disability; years of life lost to disease; yellow adipose tissue",Analysis of Fatty Liver in the Framingham Heart Study Cohort,,80145,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,3,185544,
7765535,K23,EY,5,,02/01/2010,01/31/2011,,5K23EY017897-04,,NEI:239496;,2010,NATIONAL EYE INSTITUTE,,SAN FRANCISCO,UNITED STATES,OPHTHALMOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ACHARYA, NISHA ;",8564559;,5K23EY017897,02/01/2007,01/31/2012,"1-cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Address; Adrenal Cortex Hormones; Advocate; Affect; Algorithms; Ancillary Study; Antibiotic Agents; Antibiotic Drugs; Antibiotic susceptibility; Antibiotics; Bacteria; Body Tissues; California; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Characteristics; Cicatrix; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cornea; Corneal Ulcer; Corticoids; Corticosteroids; Cytotoxic Antibiotics; D. pneumoniae; D.pneumoniae; Data; Defect; Diplococcus pneumoniae; Enrollment; Epithelium, Anterior Corneal; Epithelium, Corneal; Eye; Eye Infections; Eyeball; Fear; Foundations; Fright; Funding; Genetics, Other; Goals; HOSP; Hand; Hospitals; INFLM; Immune; In Vitro; India; Infection; Inflammation; Infrastructure; Investigators; K-Awards; K-Series Research Career Programs; Keratitis; Keratitis, Ulcerative; Laboratories; Lead; Left; Logistics; Measures; Mediating; Medical center; Mentorship; Minimum Inhibitory Concentration measurement; Minimum Inhibitory Concentrations; Miscellaneous Antibiotic; Modeling; Moxifloxacin; Ocular Infections; Organism; Other Genetics; Outcome; Outcome Measure; P. aeruginosa; P.aeruginosa; PBO; Partial Sight; Pathogenicity Factors; Patients; Pb element; Placebos; Pneumococcus; Predisposition; Programs (PT); Programs [Publication Type]; Pseudomonas aeruginosa; Pseudomonas pyocyanea; QOL; Quality of life; Relative; Relative (related person); Research; Research Career Program; Research Career Programs, K-Series; Research Infrastructure; Research Personnel; Research Proposals; Researchers; Resolution; Risk; S. pneumoniae; SUBGP; Sampling; San Francisco; Scars; Sham Treatment; Specialist; Steroid Compound; Steroid therapy; Steroids; Streptococcus pneumoniae; Structure of corneal epithelium; Subgroup; Susceptibility; Therapeutic Corticosteroid; Time; Tissues; Topical Corticosteroids; Training; Translating; Translatings; Universities; Virulence Factors; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual; Visual Acuity; Visual impairment; anti-microbial; antimicrobial; base; blind; career; clinical investigation; cornea ulcer; corneal; corneal epithelial; corneal epithelium; corneal ulceration; cytotoxic; design; designing; enroll; evidence base; experience; functional status; heavy metal Pb; heavy metal lead; improved; language translation; living system; primary outcome; programs; randomized placebo controlled study; randomized placebo controlled trial; response; sham therapy; skills; visually impaired",Predicting and Improving Clinical Outcomes for Bacterial Keratitis,,17897,ZEY1,Special Emphasis Panel,,4,239496,
7762220,K23,EY,5,,02/01/2010,01/31/2011,PA-05-143,5K23EY019353-02,,NEI:196995;,2010,NATIONAL EYE INSTITUTE,,ROCHESTER,UNITED STATES,OPHTHALMOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"HINDMAN, HOLLY BUTLER;",9249465;,5K23EY019353,02/01/2009,01/31/2014,"Accounting; Address; Agonist; Allografting; Animal Model; Animal Models and Related Studies; Anterior; Area; Astigmatism; Attenuated; Body Tissues; Bullous Keratopathy; Cats; Cell-Extracellular Matrix; Cellular biology; Clinical; Clinical Research; Clinical Study; Cold-Insoluble Globulins; Collaborations; Collagen; Confocal Microscopy; Cornea; Corneal Injury; Corneal Transplantation; Cytotacin; Cytotactin; Deposit; Deposition; Descemet's Membrane; Descemet's membrane; Domestic Cats; ECM; Education; Educational aspects; Endothelium; Epithelial; Extracellular Matrix; Eye; Eyeball; FLR; FN1; FNZ; Failure (biologic function); Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fibronectin 1; Fibronectins; Fuch's Endothelial Dystrophy; Fuchs' Endothelial Dystrophy; Fuchs' dystrophy; Future; GFAC; Generations; Goals; Grafting, Corneal; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Healed; Hexabrachion; Histology; Histopathology; Holly; Human; Human, General; Image; Institutes; Investigators; Keratectomy, Laser; Keratoplasty; LETS Proteins; Lamina Elastica Posterior; Large External Transformation-Sensitive Protein; Lead; Mammals, Cats; Man (Taxonomy); Man, Modern; Master of Science; Measures; Mediating; Microscopy, Confocal; Modeling; Morphology; Myofibroblast; Nature; Operation; Operative Procedures; Operative Surgical Procedures; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Optics; Outcome; Partial Sight; Pathway interactions; Patients; Pb element; Photokeratectomy; Photorefractive Keratectomy; Play; Post-Operative; Postoperative; Postoperative Period; Procedures; Programs (PT); Programs [Publication Type]; Recovery; Research; Research Personnel; Researchers; Role; Secondary to; Sight; Sma; Smooth Muscle Actin; Smooth Muscle Actin Staining Method; Structure of Descemet's membrane; Surgical; Surgical Interventions; Surgical Procedure; TNC; Tenascin; Tenascin-C; Testing; Therapeutic Intervention; Thick; Thickness; Time; Tissue Engineering; Tissues; Training; Translational Research; Translational Research Enterprise; Translational Science; Transplantation; Transplantation, Cornea; Universities; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual; Visual impairment; Work; Wound Healing; Wound Repair; alpha 2-Surface Binding Glycoprotein; aqueous; cell biology; corneal; corneal keratoplasty; corneal surgery; corneal transplant; corneal wound; density; dystrophia epithelialis corneae; engineered tissue; experience; experiment; experimental research; experimental study; failure; healing; heavy metal Pb; heavy metal lead; imaging; improved; in vivo; insight; intervention therapy; light scattering; model organism; pathway; programs; research study; response; skills; social role; surgery; tissue repair; tool; translation research enterprise; transplant; vision science; visual performance; visually impaired; wound","Corneal Wound Healing, Ocular Optics, and Endothelial Keratoplasty",,19353,ZEY1,Special Emphasis Panel,,2,196995,
7759585,K23,HL,5,,02/01/2010,01/31/2011,PA-00-004,5K23HL076264-05,,NHLBI:124038;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,PEDIATRICS,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"KANNANKERIL, PRINCE JOSEPH;",7740356;,5K23HL076264,02/01/2006,01/31/2011,"Accessory Sinuses; American; Area; Arrhythmia; Autonomic Nerve Block; Award; Bicycling; Candidate Disease Gene; Candidate Gene; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Chronotropism, Cardiac; Chronotropisms, Cardiac; Clinical Investigator; Clinical Research; Clinical Study; Death, Sudden; Death, Sudden, Cardiac; Drugs; ECG; EKG; Electrocardiogram; Electrocardiography; Environment; Epidemiology, Family Medical History; Exercise; Exercise, Physical; Family Medical History; Family history of; Genetic; Genetic Polymorphism; Genetics, Other; Goals; Hand; Heart Arrhythmias; Heart Diseases; Heart Rate; Individual; Intracellular Communication and Signaling; Investigators; Ion Channel; Ionic Channels; Killings; LVEF; Left Ventricular Ejection Fraction; Mediating; Medication; Membrane Channels; Mentors; Method LOINC Axis 6; Methodology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)methanesulfonamide; Nasal Sinuses; Nasal cavity/Paranasal; Nasal cavity/Paranasal sinuses; Other Genetics; Outcome; Paranasal Sinuses; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiology; Polymorphism (Genetics); Polymorphism, Genetic; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Recovery; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Factors; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sinus; Stress; Sudden Death; Syndrome; Tachyarrhythmias; Testing; Time; Ventricular; autonomic block; base; biological signal transduction; drug/agent; experience; heart disorder; heart rate variability; ibutilide; novel; polymorphism; population based; programs; public health medicine (field); response; skills; social role; tachyrhythmia",Genetic Predictors of QT Response During Exercise,,76264,ZHL1,Special Emphasis Panel,,5,124038,
7768384,K23,HL,5,,02/01/2010,01/31/2011,PA-05-143,5K23HL083089-03,,NHLBI:140130;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"LANZKRON, SOPHIE M;",2085313;,5K23HL083089,03/01/2008,01/31/2013,"21+ years old; Accounting; Address; Adherence; Adherence (attribute); Admission; Admission activity; Adult; Adverse effects; Affect; Agreement; Applications Grants; Attitude; Award; Awareness; Awarenesses; Behavior; Behavioral Research; Belief; Care Givers; Caregivers; Caring; Chronic; Chronic Disease; Chronic Illness; Clinical; Clinical Practice Guideline; Clinical Practice Guidelines; Clinical Research; Clinical Study; Compliance behavior; Cost Savings; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Delivery of Health Care; Development; Disease; Disorder; Drugs; Education for Intervention; Educational Intervention; Effectiveness; Employee Strikes; Environmental Factor; Environmental Risk Factor; Epidemiology; Expectancy; FDA approved; Familiarity; Focus Groups; Frequencies (time pattern); Frequency; Funding; Goals; Grant Proposals; Grants, Applications; Guidelines; HOSP; Hb SS disease; HbSS disease; Health Knowledge, Attitudes, Practice; Health Sciences, Allied and Health Services Delivery; Healthcare Delivery; Hematologist; Hematology; Hemoglobin S Disease; Hemoglobin SS; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hospitalization; Hospitals; Hospitals, City; Hospitals, Metropolitan; Hospitals, Urban; Human, Adult; Hydroxycarbamid; Hydroxycarbamide; Individual; Instruction; Instruction Intervention; Intervention; Intervention Strategies; Investigation; Investigators; Knowledge; Knowledge, Attitudes, Behaviors; Knowledge, Attitudes, Practice; Lead; Learning; Length of Life; Longevity; Maryland; Medicaid; Medical; Medication; Mentors; Mentorship; Methods; Modality; Morbidity; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; PROV; Patient Care; Patient Care Delivery; Patient Compliance; Patient Cooperation; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacies; Pharmacy facility; Physicians; Pilot Projects; Play; Population; Preparation; Primary Care Physician; Principal Investigator; Programs (PT); Programs [Publication Type]; Provider; Publications; Publishing; QOC; QOL; Quality of Care; Quality of life; Reading; Recommendation; Reporting; Research; Research Personnel; Researchers; Respondent; Role; SS, Hemoglobin; Saving, Cost; Scientific Publication; Series; Sickle Cell; Sickle Cell Anemia; Specialist; Strikes; Strikes, Employee; Supervision; Survey Instrument; Surveys; Symptoms; System; System, LOINC Axis 4; TRNSF; Training Intervention; Transfusion; Treatment Compliance; Treatment Side Effects; Uncertainty; Urban Hospitals; Urea, hydroxy-; Work; acute chest syndrome; adult human (21+); base; chronic disease/disorder; chronic disorder; clinical data repository; clinical data warehouse; compliance cooperation; cost; data repository; disease/disorder; doubt; drepanocyte; drug addict; drug/agent; effective intervention; environmental risk; experience; health care delivery; heavy metal Pb; heavy metal lead; hospital utilization; hydroxyurea; improved; instructional intervention; interest; interventional strategy; life span; lifespan; meetings; patient adherence; patient centered; patient oriented; patient population; pilot study; prevent; preventing; programs; prospective; randomized trial; relational database; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; sickling; side effect; social role; success; therapy adverse effect; therapy compliance; therapy cooperation; treatment adverse effect",Sickle Cell Disease: First steps toward understanding barriers to care for adults,,83089,ZHL1,Special Emphasis Panel,,3,140130,
7761728,K23,HL,5,,02/01/2010,01/31/2011,PA-00-004,5K23HL084052-04,,NHLBI:154758;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"ZWICKER, JEFFREY ;",8346615;,5K23HL084052,02/05/2007,01/31/2012,"Abscission; Acute; Address; Applications Grants; Back; Bizzozero's corpuscle/cell; Blood; Blood Coagulation Factor III; Blood Plasma; Blood Platelets; Blood Sample; Blood specimen; Brain; CD142 Antigens; Cancer Patient; Cancer of the Ovary; Cancers; Carcinoma, Non-Small-Cell Lung; Cause of Death; Clinical; Coagulation Factor III; Coagulin; Colon; Control Groups; Cytofluorometry, Flow; Data; Deetjeen's body; Detection; Diagnosis, Ultrasound; Disease; Disorder; Dorsum; Echography; Echotomography; Electrical Impedance; Encephalon; Encephalons; Event; Excision; Extirpation; Factor III; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gastrointestinal Tract, Pancreas; Gaussian Distribution; Glomerular Procoagulant Activity; Goals; Grant Proposals; Grants, Applications; Hayem's elementary corpuscle; History; Human; Human, General; Impedance; Incidence; Individual; Investigation; Investigators; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Man (Taxonomy); Man, Modern; Marrow platelet; Measurable; Measures; Medical Imaging, Ultrasound; Methods; Microfluorometry, Flow; Molecular; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Nervous System, Brain; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Normal Distribution; Normal Statistical Distribution; Operation; Operative Procedures; Operative Surgical Procedures; Ovarian; Pancreas; Pancreas Adenocarcinoma; Pancreas Cancer; Pancreatic; Pancreatic Adenocarcinoma; Pancreatic Cancer; Patients; Plasma; Platelets; Prevention; Programs (PT); Programs [Publication Type]; Prospective Studies; Prothrombinase; Recording of previous events; Removal; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Platelets; Reticuloendothelial System, Serum, Plasma; Sampling; Screening procedure; Serum, Plasma; Source; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survey Instrument; Surveys; Syndrome; Technology; Thrombocytes; Thromboplastin; Thrombosis; Thrombus; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Translating; Translatings; Tumor Cell; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Urothromboplastin; Venous; base; biomarker; diagnostic ultrasound; disease/disorder; electric impedance; flow cytophotometry; improved; in vivo; language translation; light scattering; malignancy; neoplasm/cancer; neoplastic cell; nonsmall cell lung cancer; novel; ovarian cancer; particle; programs; resection; screening; screenings; sonogram; sonography; sound measurement; surgery; thrombocyte/platelet; ultrasound; ultrasound imaging; ultrasound scanning",Bloodborne tissue factor-bearing microparticles in Trousseau's syndrome,,84052,ZHL1,Special Emphasis Panel,,4,154758,
7761281,K23,HL,5,,02/01/2010,01/31/2011,PA-05-143,5K23HL084054-04,,NHLBI:136485;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"SCOTT, BART L;",8043254;,5K23HL084054,02/05/2007,01/31/2012,"1,4-Bis(methanesulfonoxy)butane; 1,4-Bitanediol Dimethanesulfonate Esters; 1,4-Butanediol, dimethanesulfonate; 1,4-Di(methanesulfonyloxy)butane; 1,4-Di(methylsulfonyloxy)butane; 2-Fluoro-9-beta-arabinofuranosyladenine; 2-Fluorovidarabine; 2-fluoroadenine arabinoside; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5-AC; 5-Aza-cytidine; 5-Azacytidine; 9-Beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine; 9-Beta-D-arabinofuranosyl-2-fluoroadenine; AML - Acute Myeloid Leukemia; AZC; Address; Advisory Committees; Age; Allogenic; Azacitidine; Azacytidine; Blood (Leukemia); Bussulfam; Busulfan; Busulfanum; CTX; CYCLO-cell; Cancer Radiotherapy; Carloxan; Cell Transplantation; Cells; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; Clinical; Clinical Investigator; Clinical Trials Design; Clinical Trials, Phase III; Consent; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytoxan; Data; Debulking; Development; Development Plans; Diagnosis; Disadvantaged; Disease; Disorder; Dose; Drug Kinetics; Dysmyelopoietic Syndromes; ELIG; Eligibility; Eligibility Determination; Endoxan; Endoxana; Enduxan; Engraftment; Enrollment; Environment; Epidemiology; Ethics Committees, Research; Evaluation; F Ara A; FTI; Farnesyl Transferase Inhibitor; Farnesyltransferase Inhibitors; Feedback; Fosfaseron; Fostering; Fred Hutchinson Cancer Research Center; Future; GVL; Genoxal; Genuxal; Goals; Graft vs Leukemia Effect; Graft-vs-Leukemia Response; Hematopoietic; Hepatic; High Dose Chemotherapy; IMiD3 cpd; IRBs; Institution; Institutional Review Boards; Intermediary Metabolism; Intravenous; Investigators; Ledoxina; Leukemia, Myelocytic, Acute; Leukemias, General; METBL; Marrow; Master's Degree; Mediating; Mentorship; Metabolic Processes; Metabolism; Methanesulfonic acid, tetramethylene ester; Mitoxan; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Myeloblastic Leukemia, Acute; Myelodysplastic Syndromes; Myelogenous Leukemia, Acute; Myeloid Disease; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; Neosar; Oral; Outcome; Patients; Pharmacokinetics; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Pilot Projects; Plans, Development; Postdoc; Postdoctoral Fellow; Preparation; Prevention of relapse; Principal Investigator; Procytox; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Farnesyltransferase Inhibitors; Protocol; Protocol Screening; Protocols documentation; Publishing; QOL; Quality of life; Radiation therapy; Radiation, Whole-Body; Radiotherapeutics; Radiotherapy; Regimen; Relapse; Reporting; Research; Research Associate; Research Ethics Committees; Research Personnel; Researchers; Risk; SAE; SUBGP; Sendoxan; Serious Adverse Event; Smoldering Leukemia; Stem cells; Subgroup; Sulfabutin; Syklofosfamid; Task Forces; Tetramethylene bis[methanesulfonate]; Time; Total Body Irradiation; Toxic effect; Toxicities; Training; Transplantation; Transplantation Conditioning; Transplantation Conditionings; Tumor Debulking; Universities; Washington; Whole-Body Irradiation; Zytoxan; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; career; career development; chemotherapy; conditioning; design; designing; disease/disorder; disorder later incidence prevention; elderly patient; enroll; fludarabine; improved; instructor; interest; irradiation; ladakamycin; lenalidomide; leukemia; meetings; myeloblast; myelodysplasia; myeloproliferative neoplasm; new approaches; novel; novel approaches; novel strategies; novel strategy; older patient; patient centered; patient oriented; patient population; phase 3 study; phase 3 trial; phase III trial; pilot study; post-doc; post-doctoral; prevent; preventing; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; prospective; protocol, phase III; study, phase III; transplant; trial comparing",Improving Allogenic Transplant Outcomes in Myeloid Malignancies,,84054,ZHL1,Special Emphasis Panel,,4,136485,
7761770,K23,HL,5,,02/01/2010,01/31/2011,PA-05-143,5K23HL086558-04,,NHLBI:114772;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,GAINESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"COOPER-DEHOFF, RHONDA M;",8512733;,5K23HL086558,02/01/2007,01/31/2012,"1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide; ACE Inhibitors; Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Angiotensin I-Converting Enzyme Inhibitors; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Antagonists, Angiotensin-Converting Enzyme; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Area; Attention; Attenuated; BP control; Benzothiadiazine Diuretics; Blood Pressure, High; CD143 Antigens; CRCA; Carboxycathepsin; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Clinical; Clinical Research Curriculum Award; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Data; Development; Development Plans; Diabetes Mellitus; Dichlothiazide; Dihydrochlorothiazide; Dipeptidyl Peptidase A; Disease; Disorder; Diuretics; Drug Interactions; Drug Therapy; Drugs; Enzyme Gene; Epidemiology; Exposure to; Florida; Future; Gene Proteins; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Guidelines; HCTZ; Hydrochlorothiazide; Hydrodiuril; Hypertension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; IRK1 channel; Individual; Insulin Resistance; International; Investigation; Investigators; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; Ions; K+ Channels, Inwardly Rectifying; K-Awards; K-Series Research Career Programs; K30 Mechanism; K30 Program; KCNJ1 gene; Kininase A; Kininase II; Kininase II Antagonists; Kininase II Inhibitors; Knowledge; Laboratories; Life; Logic; Master's Degree; Medication; Metabolic; Metabolic syndrome; Mono-S; MonoS; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Movement; Myocardial Infarct; Myocardial Infarction; Newly Diagnosed; Organ System, Cardiovascular; Patients; Pattern; Peptidyl-Dipeptidase A; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacogenomics; Pharmacotherapy; Plans, Development; Polymorphism (Genetics); Polymorphism, Genetic; Population; Potassium Channels, Inwardly Rectifying; Programs (PT); Programs [Publication Type]; Protein Gene Products; Proteins; ROMK; Randomized; Renin-Angiotensin System; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Structure; Testing; Thiazide Diuretics; Universities; Variation (Genetics); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Verapamil SR; adducin; allelic variant; attenuation; base; blood glucose regulation; blood pressure control; blood pressure homeostasis; blood pressure regulation; body movement; cardiac infarct; cardiovascular risk; cardiovascular risk factor; career; career development; case control; circulatory system; clinical investigation; cohort; conference; coronary attack; coronary infarct; coronary infarction; design; designing; diabetes; disease/disorder; drug/agent; gene product; genetic variant; glucose control; glucose homeostasis; glucose metabolism; glucose regulation; heart attack; heart infarct; heart infarction; hyperpiesia; hyperpiesis; hypertension treatment; hypertensive disease; improved; insulin resistant; insulin sensitivity; interest; inward rectifier potassium channel; patient centered; patient oriented; polymorphism; prevent; preventing; programs; prospective; randomisation; randomization; randomly assigned; renal outer medullary potassium channel; response; social role; symposium; thiazide; trandolapril",Metabolic Effects of Antihypertensive Drugs,,86558,ZHL1,Special Emphasis Panel,,4,114772,
7827974,K23,HL,5,,02/01/2010,01/31/2011,PA-05-143,5K23HL087030-03,,NHLBI:151881;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ROSAS, IVAN O.;",8594873;,5K23HL087030,05/04/2008,01/31/2013,"Accelerated interstitial pneumonitis; Acidophilic Leukocyte; Acute; Acute Disease; Acute Interstitial Pneumonitis; Address; Affect; Allergy; Alveolar; Alveolar Macrophages; Assay; Binding; Binding (Molecular Function); Bioassay; Bioavailability; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Blood; Blood Eosinophil; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Bone-Derived Transforming Growth Factor; Bronchial Lavage Fluid; CCL2; CCL2 gene; Candidate Disease Gene; Candidate Gene; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cells; Clinical; Co-Immunoprecipitations; Cohort Studies; Collaborations; Concurrent Studies; Critical Care; Cytokines, Chemotactic; DNA Synthesis Factor; Desquamative interstitial pneumonitis; Development; Disease; Disease Progression; Disorder; Douching, other than vaginal; ECGF; Endothelial Cell Growth Factor; Endothelial Cells; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Esteroproteases; Extracellular Matrix Proteins; FGF; Family; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Fibrosing Alveolitis; Fibrosis; Forecast of outcome; Fostering; Foundations; Future; GDCF-2; GDCF-2 HC11; GFAC; Gel; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF; HC11; HL-60; HL60; HOSP; HSPG; Hamman-Rich syndrome; Heparan Sulfate Proteoglycan; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Hospitalization; Human; Human, General; Hypersensitivity; ILD; Idiopathic ARDS; Idiopathic Interstitial Pneumonia; Individual; Injury; Intercrines; Interstitial Lung Diseases; Intracellular Communication and Signaling; Investigators; Irrigation; Irrigation, other than vaginal; Knowledge; Laboratories; Lavage; Lavage Fluids, Alveolar; Length of Stay; Leukocytes; Ligands; Lung; Lung Diseases, Interstitial; Lung Lavage Fluid; Lung Parenchyma; Lung Tissue; Lung diseases; MCAF; MCP-1; MCP1; MGC9434; Macrophages, Alveolar; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Marrow Neutrophil; Marrow leukocyte; Measurement; Medical; Medicine; Membrane; Microarray Analysis; Microarray-Based Analysis; Milk Growth Factor; Molecular Interaction; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neutrophilic Granulocyte; Neutrophilic Leukocyte; Non-specific interstitial neumonia/fibrosis; Nonvaginal irrigation; Nonvaginal lavage; Number of Days in Hospital; Pathogenesis; Patients; Pattern; Peptidases; Peptide Hydrolases; Physiologic Availability; Platelet Transforming Growth Factor; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Profilings, Gene Expression; Prognosis; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteoheparan Sulfate; Proteolytic Enzymes; Proteomics; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Macrophages; Receptor Signaling; Regulation; Research; Research Personnel; Researchers; Respiration Disorders; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Role; SCYA2; SIS cytokines; SMC-CF; Science of Medicine; Severities; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Stable Disease; Staging; Structure of parenchyma of lung; TGF B; TGF-beta; TGFbeta; Testing; Therapeutic; Transcript Expression Analyses; Transcript Expression Analysis; Transforming Growth Factor beta; United States; United States National Institutes of Health; Universities; Up-Regulation; Up-Regulation (Physiology); Upregulation; Usual Interstitial Pneumonia; Usual Interstitial Pneumonitis; White Blood Cells; White Cell; acute disease/disorder; acute disorder; base; bioavailability of drug; biological signal transduction; career; chemoattractant cytokine; chemokine; chemokine receptor; cohort; cytokine; diffuse interstitial pulmonary fibrosis; disease severity; disease/disorder; eosinocyte; eosinophil; experience; experiment; experimental research; experimental study; fibroglycan; gene product; hospital days; hospital length of stay; hospital stay; idiopathic pulmonary fibrosis; insight; irrigation therapy; lavage therapy; lung disorder; macrophage; member; membrane structure; microarray technology; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; neutrophil; outcome forecast; overexpression; peripheral blood; programs; protein protein interaction; pulmonary; receptor binding; research study; skills; social role; syndecan; syndecan-2; white blood cell; white blood corpuscle",Syndecan-2 and Clinical Progression of Idiopathic Pulmonary Fibrosis,,87030,ZHL1,Special Emphasis Panel,,3,151881,
7754456,K23,HL,5,,01/01/2010,12/31/2010,PA-05-143,5K23HL087934-03,,NHLBI:141750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BAJWA, EDNAN K.;",2088278;,5K23HL087934,01/04/2008,12/31/2012,"3-10C; AMCF-I; ARDS; ARDS, Human; ARDSs, Human; Acute respiratory failure; Adult RDS; Adult Respiratory Distress Syndrome; Alleles; Allelomorphs; Apopain; Apoptosis; Apoptosis Pathway; B blood cells; B-Cells; B-Lymphocytes; BNP Gene Product; BNP-32; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Brain Natriuretic Peptide-32; Brain natriuretic peptide; Bronchioalveolar Lavage; Bronchoalveolar Lavage; Burn injury; Burns; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-reactive protein; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; CSBP1; CSBP2; CSPB1; CXCL8; Candidate Disease Gene; Candidate Gene; Cardiac; Cardiopulmonary Bypass; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Death, Programmed; Clinical; Clinical Research; Clinical Study; Critical Care; Cysteine Protease CPP32; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; Disorder; Dysfunction; EXIP; Enrollment; Epidemiology; Epidemiology, Molecular; FLJ12216; Faculty; Fellowship; Forecast of outcome; Functional disorder; Funding; GCP-1; GCP1; Gene variant; General Hospitals; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Techniques; Genetic Variation; Genotype; Goals; Grant; Haplotypes; Heart-Lung Bypass; Heterophil Granulocyte; Hospitals, General; Humulin R; Hyperglycemia; IL-8; IL8; IL8 gene; Immune response; Industrial Medicine; Infection; Inherited Predisposition; Inherited Susceptibility; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intensive Care; Internal Medicine; Intervention; Intervention Strategies; Investigators; K60; KRP; LECT; LUCT; LYNAP; Laboratories; Lavage, Bronchopulmonary; Lung; Lung Lavage; MAPK14; MAPK14 gene; MDNCF; MLCK; MLCK108; MLCK210; MOF syndrome; MONAP; MYLK; MYLK gene; Marrow Neutrophil; Massachusetts; Measures; Mediating; Medical; Medicine; Mentors; Molecular Epidemiology; Mortality; Mortality Vital Statistics; Multiple Organ Failure; Mxi2; N-terminal; NAF; NH2-terminal; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natriuretic Factor-32; Natriuretic factor, brain; Nesiritide; Neutrophilic Granulocyte; Neutrophilic Leukocyte; New York; Novolin R; Occupational Medicine; Occupational or Industrial Medicine; Organ Dysfunction Syndrome, Multiple; Outcome; PARP Cleavage Protease; PBEF; PRKM14; PRKM15; Pancreatitis; Pathogenesis; Pathway interactions; Patients; Phenotype; Physiopathology; Pneumonia; Pneumonitis; Polymorph; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Pre-B Cell Enhancing Factor; Pre-B-Cell Colony-Enhancing Factor; Principal Investigator; Process; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; Proteins, specific or class, C-reactive; Public Health; Public Health Schools; Pulmonary Inflammation; Regulation; Research; Research Personnel; Research Proposals; Researchers; Residencies; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Risk; Risk Factors; Role; SAPK2A; SCA-1; SCYB8; SNP; SNPs; SREBP Cleavage Activity 1; Schools, Medical; Schools, Public Health; Science of Medicine; Sepsis; Serum; Severity of illness; Shock Lung; Single Nucleotide Polymorphism; Stimulus; TNT; TRNSF; TSG-1; Technics, Genetic; Training; Training Programs; Training of Investigators; Transfusion; Trauma; Troponin T; Type-B Natriuretic Peptide; United States National Institutes of Health; Universities; Variant; Variation; Variation (Genetics); Work; Yama; Yama protein; allelic variant; b-ENAP; base; biomarker; bloodstream infection; bronchopulmonary lavage therapy; career; caspase-3; cohort; cysteine protease P32; design; designing; diabetes; diabetes risk; disease severity; disease/disorder; effective therapy; enhancing factor; enroll; gene product; genetic etiology; genetic mechanism of disease; genetic vulnerability; heart bypass; high risk; host response; hyperglycemic; immunoresponse; improved; insight; interest; interventional strategy; investigator training; medical schools; molecular marker; multiple organ system failure; neutrophil; novel; outcome forecast; p38; p38 MAPK Gene; p38Alpha; pathophysiology; pathway; polymorphism; pre-B-cell colony-enhancing factor protein; professor; prognostic; programs; prospective; public health medicine (field); pulmonary; response; social role; tropomyosin binding protein troponin T","Molecular Markers of Risk, Phenotype, and Outcomes in ARDS",,87934,ZHL1,Special Emphasis Panel,,3,141750,
7849031,K23,HL,5,,02/01/2010,01/31/2011,PA-05-143,5K23HL095739-02,,NHLBI:127452;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ANN ARBOR,UNITED STATES,NEUROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"O'BRIEN, LOUISE M;",7946170;,5K23HL095739,06/01/2009,01/31/2014,"21+ years old; Admission; Admission activity; Adult; Affect; Apgar Score; Apnea, Sleep; Blood Pressure; Blood Pressure Monitors; Blood Pressure, High; CPAP; CPAP Ventilation; Cessation of life; Chronic; Consent; Continuous Positive Airway Pressure; Controlled Clinical Trials, Randomized; Data; Death; Disease; Disorder; Eclampsia; Enrollment; Female Groups; Frequencies (time pattern); Frequency; Gestation; Gestosis, EPH; Goals; Health; High-Risk Pregnancy; Human, Adult; Hypertension; Incidence; Infant; Infant, Newborn, Intensive Care; Instruction; Instrumentation, Other; Intensive Care Units, Neonatal; Intensive Care, Neonatal; Measures; Medical Records; Monitor; Monitoring, Sleep; Morbidity; Morbidity - disease rate; Mothers; Neonatal Intensive Care; Neonatal Intensive Care Units; Newborn Intensive Care Units; Newly Diagnosed; Outcome; Patient Care; Patient Care Delivery; Patients; Pattern; Physiologic; Physiological; Play; Polysomnography; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnancy Complications; Pregnant Women; Pressure; Pressure- physical agent; Principal Investigator; Proteinuria; Proteinuria-Edema-Hypertension Gestosis; Randomized Controlled Clinical Trials; Reporting; Research; Risk Factors; Role; Severities; Sleep; Sleep Apnea Syndromes; Sleep Hypopnea; Sleep-Disordered Breathing; Snoring; Snorings; Somnography; Sphygmomanometers, Continuous; Symptoms; Time; Toxemias, Pregnancy; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weight Gain; Weight Increase; Woman; Women's Group; abstracting; adult human (21+); body weight gain; body weight increase; comparison group; disease/disorder; enroll; fetal; hyperpiesia; hyperpiesis; hypertensive disease; improved; in utero; infant outcome; instrumentation; novel; polysomnographic; pregnancy toxemia/hypertension; pregnant; pressure; randomized trial; sleep measurement; sleep polysomnography; social role; standard care; wt gain",Use of PAP in women with pre-eclampsia,,95739,ZHL1,Special Emphasis Panel,,2,127452,
7756604,K23,MH,5,,02/01/2010,01/31/2011,PA-00-004,5K23MH073091-05,,NIMH:167066;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DURHAM,UNITED STATES,PSYCHIATRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"MOREY, RAJENDRA A;",6894168;,5K23MH073091,02/01/2006,01/31/2011,"Address; Affect; Ammon Horn; Anterior; Appointment; Area; Attention; Award; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Therapy, Cognitive; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Brain; Brain imaging; Brain region; Chronic; Clinical; Clinical Research; Clinical Study; Cognitive; Cognitive Therapy; Conditioning Therapy; Conscious; Consciousness; Control Groups; Cornu Ammonis; Data; Disease; Disorder; Dorsal; Dysfunction; Emotional; Emotions; Encephalon; Encephalons; Environment; Ethics, Research; Event; Faculty; Fluoxetin; Fluoxetine; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hippocampus; Hippocampus (Brain); History; IQ Deficit; Image Analyses; Image Analysis; Imagery; Individual; Investigation; Knowledge; Lateral; Left; Life Style Modification; Literature; Location; MRI, Functional; Magnetic Resonance Imaging, Functional; Maps; Measures; Medial; Mediating; Medical Imaging, Positron Emission Tomography; Memory; Memory Deficit; Memory impairment; Mentors; Metabolic; Methodology, Research; Metric; Modeling; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Nervous; Nervous System, Brain; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurobiology; Neurocognitive; Neurocognitive Deficit; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Nightmare; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; PET; PET Scan; PET imaging; PETSCAN; PETT; PTSD; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Patients; Performance; Peripheral; Physiopathology; Play; Population; Positron Emission Tomography Scan; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Prefrontal Cortex; Prevention; Process; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Psychiatry; Psychometric; Psychometrics; Psychotherapy, Cognitive; Pus; ROC Analysis; Rad.-PET; Reading; Recording of previous events; Recovery; Recurrence; Recurrent; Reporting; Research; Research Ethics; Research Methodology; Research Methods; Retrieval; Role; Selective inattention; Series; Severity of illness; Stimulus; Stream; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Symptoms; Syndrome; Testing; Therapeutic; Therapy, Cognition; Thinking; Thinking, function; Training; Trauma; Universities; Visual Cortex; Visualization; base; behavior intervention; behavioral intervention; brain visualization; career; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; decline in function; design; designing; disease severity; disease/disorder; emotional stimulus; executive control; executive function; experience; experiment; experimental research; experimental study; fMRI; functional decline; hippocampal; image evaluation; improved; memory encoding; neural; neural circuit; neural circuitry; neurobiological; neuroimaging; neuropsychological; novel; parietal cortex; pathophysiology; patient oriented research; patient oriented study; programs; psychologic; psychological; relating to nervous system; research study; response; selective attention; social role; statistics/biometry; success; tool; traumatic neurosis; treatment response; visual cortical; visual information",FMRI Assessment of Attention and Memory in PTSD,,73091,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,5,167066,
7765479,K23,MH,5,,02/01/2010,01/31/2011,PA-00-004,5K23MH074079-05,,NIMH:158804;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"SILVERSTEIN, MICHAEL ;",8207047;,5K23MH074079,02/03/2006,01/31/2011,"0-11 years old; 1-5 years old; Active Follow-up; Address; Analgesic Management; Attitude; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Therapy, Cognitive; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Case Management; Child; Child Development; Child Youth; Child health care; Child, Preschool; Children (0-21); Cognitive Therapy; Communities; Conditioning Therapy; Depression; Depression screen; Development; Education; Educational aspects; Educational process of instructing; Effectiveness; Emotional; Emotional Depression; Evidence based treatment; Family; Focus Groups; Funding; Head Start; Head Start Program; Health; Health Care Utilization; Health, Child; Human, Child; Infant and Child Development; Infrastructure; Intervention; Intervention Strategies; Interview; Learning; Life Style Modification; Link; Low income; Medication Management; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental health promotion; Mentors; Methodology, Research; Morbidity; Morbidity - disease rate; Mothers; Outcome; Parent-Child Relations; Parent-Child Relationship; Perception; Pharmacologic Management; Preparedness; Preschool Child; Program, Head Start; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psyche structure; Psychological Health; Psychotherapy, Cognitive; Randomized Controlled Trials; Readiness; Research; Research Infrastructure; Research Methodology; Research Methods; Research Resources; Resources; Schools; Self Management; Services; Social Functioning; Social Support System; Source; Support System; Symptoms of depression; System; System, LOINC Axis 4; Teaching; Testing; Therapy, Cognition; Woman; base; behavior intervention; behavioral intervention; children; chronic care model; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; depressed mother; depression screening; depressive; depressive symptoms; design; designing; evidence base; experience; experiment; experimental research; experimental study; follow-up; health care service utilization; health services utilization; healthcare service utilization; healthcare utilization; improved; instrument; intervention design; interventional strategy; maternal depression; mental; parent child interaction; parent offspring interaction; preschool child (1-5); problem solving therapy; programs; randomized controlled study; research study; social; therapy design; treatment design; treatment utilization; youngster",Maternal Depression and Early Head Start,,74079,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,5,158804,
7758211,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH074581-04,,NIMH:145688;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"GOLDSTEIN, TINA R;",7845009;,5K23MH074581,02/07/2007,01/31/2012,"0-11 years old; 12-20 years old; 21+ years old; Active Follow-up; Adherence; Adherence (attribute); Adolescence; Adolescent; Adolescent Development; Adolescent Youth; Adult; Affect; Affective; Affective Psychosis, Bipolar; Age; Area; Behavior Control; Behavior assessment; Behavioral Manipulation; Bipolar Disorder; Child; Child Youth; Children (0-21); Chronic; Clinic; Clinical; Communication; Comorbidity; Complement; Complement Proteins; Conflict; Conflict (Psychology); Controlled Study; Cues; Data; Development; Dialectical behavior therapy; Drug Therapy; Elements; Emotional; Emotions; Evidence based treatment; Exhibits; Factor Analyses; Factor Analysis; Family; Family member; Future; Goals; Human, Adult; Human, Child; Impairment; Individual; Institutes; Intervention; Intervention Strategies; Investigation; K23 Award; K23 Mechanism; K23 Program; Knowledge; Manuals; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Modification; Moods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mydriasis; Nature; Neurobiology; Outcome; Participant; Patients; Pharmacotherapy; Physiologic; Physiological; Population; Population Intervention; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Psychosis, Manic-Depressive; Public Health; Pupil Dilation; R01 Mechanism; R01 Program; RPG; Race; Racial Group; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Support; Research Training; Resistance; SCHED; Schedule; Services; Statistical Methods; Stocks, Racial; Suicide; Targeted Research; Time; Training; Training Activity; Treatment outcome; adolescence (12-20); adult human (21+); affective neuroscience; base; behavioral assessment; behavioral control; bipolar affective disorder; childhood bipolar disorder; children; control trial; demographics; early onset; emotion regulation; fatal attempt; fatal suicide; follow-up; indexing; innovate; innovation; innovative; intent to die; interdisciplinary approach; intervention development; interventional strategy; juvenile; juvenile human; manic depressive disorder; manic depressive illness; meetings; mood regulation; multidisciplinary; neurobiological; pilot trial; programs; psycho-physiological; psychoeducational; psychopharmacologic; psychopharmacological; psychosocial; public health medicine (field); resistant; response; satisfaction; sex; skills; suicidality; teenage; therapy development; treatment development; treatment response; youngster",Dialectical Behavior Therapy for Bipolar Adolescents,,74581,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,4,145688,
7771695,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH074799-04,,NIMH:183235;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"PAYNE, JENNIFER L;",1908924;,5K23MH074799,02/01/2007,01/31/2012,"Affective Disorders; Affective Psychosis, Bipolar; Bipolar Disorder; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cells; Chair; Chairman; Chairperson; Chairwoman; Chemotherapy-Hormones/Steroids; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collection; Data; Data Set; Dataset; Depression; Depression, Postpartum; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Dysfunction; Emotional Depression; Endocrine Gland Secretion; Ensure; Epidemiology; Estrogenic Agents; Estrogenic Compounds; Estrogens; Family; Family Study; Fellowship; Five-Year Plans; Foundations; Functional disorder; Future; Genes; Genetic; Genetic Determinism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Research; Genetic Susceptibility; Goals; History; Hormonal Change; Hormones; Individual; Inherited Predisposition; Inherited Susceptibility; Interview; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Linkage Analysis; Major Depressive Disorder; Mental Depression; Mental Health; Mental Hygiene; Mentors; Mood Disorders; Moods; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); North Carolina; Patients; Pb element; Physiopathology; Plans, Five-Year; Population; Position; Positioning Attribute; Post-Natal Depression; Post-Partum Depression; Postnatal Depression; Postpartum; Postpartum Depression; Postpartum Period; Pregnant Women; Psychiatrist; Psychiatry; Psychological Health; Psychosis, Manic-Depressive; Public Health Schools; Recording of previous events; Recurrence; Recurrent; Reproductive Endocrinology; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Resources; Researchers; Resources; Response Elements; Risk; SUBGP; Sampling; Schools, Public Health; Science of Statistics; Series; Statistical Methods; Statistics; Steroid Compound; Steroids; Subgroup; Symptoms; Symptoms of depression; Testing; Therapeutic Estrogen; Therapeutic Hormone; Time; Training; Training Programs; Treatment outcome; United States National Institute of Mental Health; Universities; Variant; Variation; Woman; Work; base; bipolar affective disorder; clinical investigation; depressive; depressive symptoms; family based linkage study; genetic determinant; genetic epidemiology; genetic etiology; genetic linkage analyses; genetic linkage analysis; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interest; linkage analyses; major depression; manic depressive disorder; manic depressive illness; neurobehavioral; pathophysiology; professor; statistics; trait; treatment strategy",Genetics of Postpartum Depression in Affective Disorders,,74799,APDA,Adult Psychopathology and Disorders of Aging Study Section,,4,183235,
7762711,K23,MH,5,,02/01/2010,01/31/2011,,5K23MH076049-05,,NIMH:176861;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GRUNEBAUM, MICHAEL F;",8260734;,5K23MH076049,02/06/2006,01/31/2011,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone; 2-Methyl-3-o-tolyl-4(3H)-quinazolinone; 3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline; Admission; Admission activity; Affective Disorders; Aggression; Aggressive behavior; Alleles; Allelomorphs; American; Amfebutamone; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Area; Attention; Award; Bupropion; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cause of Death; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Consultations; DSM; Depressed mood; Depression; Depression and Suicide; Development; Diagnostic and Statistical Manual; Diathesis; Disease susceptibility; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; Event; Feeling suicidal; Fluoxetin; Fluoxetine; Frequencies (time pattern); Frequency; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Goals; HOSP; History; Hospitals; Impulsivity; Investigators; K-Awards; K-Series Research Career Programs; Knowledge; MAOA; MTQ; Major Depression, single episode; Major Depressive Disorder; Major Depressive Disorder, Single Episode; Major depressive disorder, single episode, unspecified degree; Measures; Mediating; Medication; Mental Depression; Mental disorders; Mental health disorders; Mentors; Mentorship; Methaqualone; Methods; Metolquizolone; Mood Disorders; Moods; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Neurobiology; Neuropsychologic Tests; Neuropsychological Tests; Ortonal; Paroxetine; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenetics; Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-; Polymorphism (Genetics); Polymorphism, Genetic; Prevention of suicide; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psychiatric Disease; Psychiatric Disorder; R01 Mechanism; R01 Program; RPG; Randomized; Recording of previous events; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk Factors; Sampling; Serotonergic Agents; Serotonergic Drugs; Serotonin Agents; Serotonin Drugs; Severities; Single Episode of Major Depressive Disorder; Single major depression; Single major depressive episode; Statistical Methods; Suicidal thoughts; Suicide; Suicide attempt; Suicide precaution; Suicide prevention; Therapeutic Effect; Training; Unspecified Mental Disorder; Variant; Variation; Variation (Genetics); Work; allelic variant; buproprion; career development; clinical investigation; depressed; disability; disease/disorder proneness/risk; drug/agent; experience; fatal attempt; fatal suicide; genetic epidemiology; high risk; improved; intent to die; knowledge base; liability to disease; major depression; major depressive episode; male; mental illness; neurobiological; neuropsychological; non fatal attempt; patient centered; patient oriented; polymorphism; prevent; preventing; programs; psychological disorder; randomisation; randomization; randomly assigned; response; sadness; sex; single episode major depressive disorder; skills; suicidal; suicidal act; suicidal attempt; suicidal behavior; suicidal ideation; suicidal risk; suicidal thinking; suicidality; suicide act; suicide behavior; suicide ideation; suicide intervention; suicide risk; thoughts about suicide; trial comparing",Paroxetine/Bupropion in Suicide Attempters/Ideators with Major Depression,,76049,ITV,Interventions Research Review Committee,,5,176861,
7759603,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH076937-04,,NIMH:181908;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,,01,069847804,US,RI,02906,"BUTLER HOSPITAL (PROVIDENCE, RI)","GAUDIANO, BRANDON A;",7081468;,5K23MH076937,02/01/2007,01/31/2012,"Acute; Adherence; Adherence (attribute); Affective Disorders; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Area; Articulation; Award; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biological; Caring; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Combined Modality Therapy; Competence; Conditioning Therapy; Convulsive Therapy, Electric; Data; Depressed mood; Depression; Development; Diagnostic; Disease; Disorder; Drug Therapy; Drugs; Electroconvulsive Psychotherapy; Electroconvulsive Shock Therapy; Electroconvulsive Therapy; Electroconvulsive treatment; Electroshock Psychotherapy; Electroshock Therapy; Electroshock treatment; Ethics; Evidence based practice; Functional impairment; Future; Goals; Grant; HOSP; Hospitals; Individual; Inpatients; Intervention; Intervention Strategies; Investigators; Joints; K23 Award; K23 Mechanism; K23 Program; Knowledge; Life Style Modification; Major Depressive Disorder; Major Tranquilizers; Manuals; Manuscripts; Measures; Medication; Mental Depression; Mental Patients; Mentally Ill; Mentally Ill Persons; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Mentorship; Mood Disorders; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Out-patients; Outcome; Outpatients; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Pilot Projects; Population; Preparation; Prevalence; Price; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Protocols, Treatment; Psychoses; Psychotherapy; Psychotic Disorders; Public Health; R01 Mechanism; R01 Program; RGM; RPG; Randomized; Regimen; Relapse; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Risk; Schizophrenia; Schizophrenic Disorders; Schools, Medical; Scientist; Severities; Shock Therapy, Electric; Specific qualifier value; Specified; Structure; Suicide; Symptoms; Testing; Training; Training Programs; Tranquilizing Agents, Major; Treatment Protocols; Treatment Regimen; Treatment Schedule; Work; Writing; base; behavior intervention; behavioral intervention; clinical investigation; combination therapy; combined modality treatment; combined treatment; dementia praecox; depressed; design; designing; disease/disorder; drug/agent; efficacy trial; electric shock treatment; electro-convulsive therapy; electroplexy shock therapy; experience; fatal attempt; fatal suicide; functional disability; high risk; improved; innovate; innovation; innovative; intent to die; intervention design; intervention development; interventional strategy; major depression; medical schools; meetings; multimodality therapy; non-psychotic depression; nonpsychotic depression; novel; patient population; pilot study; pricing; programs; psychosocial; psychotic depression; public health medicine (field); randomisation; randomization; randomly assigned; response; routine care; sadness; schizophrenic; shock treatment; skills; suicidality; therapy design; therapy development; treatment design; treatment development; treatment trial",Development of a Psychosocial Treatment for Psychotic Depression,,76937,ITMA,Interventions Committee for Adult Mood and Anxiety Disorders,,4,181908,
7758837,K23,MH,5,,02/01/2010,01/31/2011,PA-00-004,5K23MH077044-04,,NIMH:185220;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"FERTUCK, ERIC A;",7898585;,5K23MH077044,02/15/2008,01/31/2013,"21+ years old; Adult; Aggression; Aggressive behavior; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anterior; Arousal; Attention; Automated Information Processing; Automatic Information Processing; BPD; Behavior; Behavioral; Borderline Personality Disorder; Brain region; Burn injury; Burns; Central Lobe; Childhood; Chronic; Clinical; Conscious; Consciousness; Control Groups; Cues; Deliberate Self-Harm; Diagnostic; Dimensions; Dorsal; Education; Educational aspects; Emotional; Emotions; Exhibits; Face; Functional Magnetic Resonance Imaging; Health Care Utilization; Human; Human, Adult; Human, General; Individual; Individual Differences; Insula; Insula of Reil; Investigators; Island of Reil; K23 Award; K23 Mechanism; K23 Program; Link; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measurement; Mental disorders; Mental health disorders; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentorship; Methods; Modeling; Mortality; Mortality Vital Statistics; Nervous; Neurobiology; Neurosciences; Pain; Painful; Participant; Patient Self-Report; Perception; Personality Disorders; Prefrontal Cortex; Prevention; Process; Processing, Automatic Information; Psychiatric Diagnosis; Psychiatric Disease; Psychiatric Disorder; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; R01 Mechanism; R01 Program; RPG; Regulation; Relative; Relative (related person); Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Researchers; Sampling; Science of Statistics; Self-Injurious Behavior; Self-Report; Statistics; Structure; Suicide; Therapeutic Intervention; Training Programs; Translational Research; Translational Research Enterprise; Translational Science; United States; Unspecified Mental Disorder; adult human (21+); amygdaloid nuclear complex; cognitive neuroscience; deliberate self harm; experience; fMRI; facial; fatal attempt; fatal suicide; health care service utilization; health services utilization; healthcare service utilization; healthcare utilization; information processing; intent to die; intentional self harm; intentional self injury; interest; intervention therapy; meetings; mental illness; neural; neural circuit; neural circuitry; neurobiological; non-suicidal self injury; pediatric; psycho-physiological; psychological disorder; relating to nervous system; response; self harm; self injury; social; social cognition; social neuroscience; statistics; suicidal; suicidality; suicide rate; tool; translation research enterprise; treatment utilization",Social Neuroscience of Borderline Personality Disorder,,77044,ZRG1,Special Emphasis Panel,,4,185220,
7760069,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH077072-04,,NIMH:180268;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"GABBAY, VILMA ;",7861828;,5K23MH077072,02/01/2007,01/31/2012,"2-Hydroxy-N,N,N-trimethylethanaminium; 21+ years old; 3-D; 3-Dimensional; Address; Adolescent; Adolescent Youth; Adult; Affective Disorders; Age; Area; Atrophic; Atrophy; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Brain; Brain region; CNS plasticity; Cell Death; Cell Membrane Lipids; Cephalic; Childhood; Choline; Clinical Research; Clinical Study; Complement; Complement Proteins; Consultations; Corpus Striatum; Corpus striatum structure; Cranial; Data; Depression; Development; Diagnostic Specificity; Diagnostics Research; Drugs; Dysfunction; Early identification; Employee Strikes; Encephalon; Encephalons; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethics; Ethnic Origin; Ethnicity; Ethnicity aspects; Functional disorder; Gender; Glia; Glial Cells; Goals; H+ element; Handedness; Heterogeneity; Human, Adult; Hydrogen Ions; Image; Investigation; Investigators; Knowledge; Kolliker's reticulum; Laterality; Link; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Major Depressive Disorder; Medication; Membrane; Membrane Lipids; Mental Depression; Mentors; Metabolic; Methodology, Research; Methods; Methods and Techniques; Methods, Other; Modeling; Mood Disorders; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurobiology; Neurochemistry; Neurocyte; Neuroglia; Neuroglial Cells; Neuronal Plasticity; Neurons; Neurosciences; Non-neuronal cell; Pathogenesis; Patient Selection; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Play; Prefrontal Cortex; Process; Protons; Public Health; Putamen; Reporting; Research; Research Methodology; Research Methods; Research Personnel; Researchers; Resolution; Role; Scanning; Science of neurochemistry; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Staging; Striate Body; Striatum; Strikes; Strikes, Employee; Structure of putamen; Techniques; Testing; Training; Youth; Youth 10-21; adult human (21+); affective neuroscience; base; biological research; career development; design; designing; drug/agent; expectation; gray matter; imaging; improved; in vivo; juvenile; juvenile human; magnetic field; major depression; meetings; membrane structure; multidisciplinary; necrocytosis; nerve cement; neural plasticity; neurobiological; neurochemistry; neuroimaging; neuronal; neuroplasticity; novel; pathophysiology; pediatric; perfusion (blood); public health medicine (field); putamen; resilience; social role; statistics/biometry; striatal; substantia grisea; tool; treatment response",The Neurobiology of Adolescent Depression,,77072,ZRG1,Special Emphasis Panel,,4,180268,
7788834,K23,MH,5,,03/01/2010,02/28/2011,PA-05-143,5K23MH077287-02,,NIMH:179388;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BELMONT,UNITED STATES,,07,046514535,US,MA,02478,"MC LEAN HOSPITAL (BELMONT, MA)","FORESTER, BRENT PETER;",8378389;,5K23MH077287,06/01/2009,02/28/2014,"3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; Affective Psychosis, Bipolar; After Care; After-Treatment; Aftercare; Age; Aged 65 and Over; Aging Process; Aging-Related Process; Amentia; Animals; Anterior; Area; Artifacts; BDNF; Belief; Biochemical; Biochemical Markers; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Bipolar Depression; Bipolar Disorder; Brain; Brain imaging; Brain-Derived Neurotrophic Factor; Care, Health; Cerebrum; Chronic; Clinical; Clinical Pharmacology; Clinical Skills; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Complex; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Defect; Dementia; Depressed mood; Desitin Brand of Lamotrigine; Development; Diagnosis; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Disease Frequency Surveys; Drugs; Dysfunction; Elderly; Elderly, over 65; Emotional Depression; Encephalon; Encephalons; Energy Expenditure; Energy Metabolism; Evaluation; Functional disorder; Future; Genes; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Gln; Glutamates; Glutamine; Goals; H+ element; HOSP; Health Services; Health system; Healthcare; History; Hospitals; Hydrogen Ions; Image; Imaging Procedures; Imaging Techniques; Imaging technology; Individual; Institutes; Interview; Investigators; L-Glutamate; L-Glutamine; Laboratories; Lamictal; Lamiktal; MGC34632; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Markers, Biochemical; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Mentors; Methods and Techniques; Methods, Other; Montgomery and Asberg depression rating scale; Mood Disorders, Psychotic; Moods; Morphologic artifacts; Mortality; Mortality Vital Statistics; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; NMR Imaging; NMR Tomography; Nervous System, Brain; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Occipital lobe; Pathology; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology, Clinical; Phase; Physiopathology; Programs (PT); Programs [Publication Type]; Protons; Psychosis, Manic-Depressive; Psychotic Mood Disorders; Public Health; Q. Levoglutamide; Recording of previous events; Reporting; Research; Research Personnel; Researchers; Scanning; Semantic; Semantics; Severities; Site; Sorting - Cell Movement; Structure; Symptoms; Symptoms of depression; Technics, Imaging; Techniques; Testing; Therapeutic; Therapeutic Intervention; Training; Wisconsin; Zeugmatography; adult youth; advanced age; bipolar affective disorder; brain visualization; burnout; career; cingulate cortex; clinical investigation; decline in function; depressed; depressive; depressive symptoms; disability; drug/agent; early onset; effective therapy; elderly patient; elders; executive control; executive function; functional decline; geriatric; health care service; imaging; inclusion criteria; information processing; intervention therapy; lamotrigine; late life; later life; manic depressive disorder; manic depressive illness; meetings; mitochondrial dysfunction; neuropsychological; occipital cortex; older adult; older patient; older person; open label; pathophysiology; processing speed; programs; public health medicine (field); public health relevance; response; responsible research conduct; sadness; senior citizen; sorting; statistics/biometry; treatment response; young adult",Cerebral Energy Metabolism in Geriatric Bipolar Depression,,77287,APDA,Adult Psychopathology and Disorders of Aging Study Section,,2,179388,
7759596,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH077662-03,,NIMH:132902;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"MELTZER, LISA J;",8153056;,5K23MH077662,02/07/2008,01/31/2013,"0-11 years old; 21+ years old; Address; Adult; Age; Amentia; Anger; Anxiety; Behavior Therapy, Cognitive; Behavioral Therapy; Broken sleep; CDC; Care Givers; Care giver Burden; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Caregiver Burden; Caregivers; Caring; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Child; Child Psychology; Child Youth; Childhood; Children (0-21); Chronic; Chronic Disease; Chronic Illness; Clinical; Clinical Research; Clinical Study; Cognitive Therapy; Dementia; Depression; Development; Difficulty in sleep maintenance; Difficulty staying asleep; Emotional Depression; Employment; Ensure; Ethical Issues; Evaluation; Family; Family Care Giver; Family Caregiver; Family member; Fatigue; Feeling; Fitful sleep; Foundations; Frequencies (time pattern); Frequency; Goals; Health; Healthcare Systems; Home; Home environment; Hour; Human, Adult; Human, Child; Interrupted sleep; Intervention; Intervention Strategies; Intervention Studies; Investigators; Issues, Ethical; Jobs; K-Awards; K-Series Research Career Programs; Knowledge; Lack of Energy; Length of Life; Literature; Longevity; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Medicine; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Mentors; Middle Insomnia; Modeling; Moods; NCHS; National Center for Health Statistics; National Center for Health Statistics (U.S.); Night Nurse; Night waking; Occupations; Parents; Patients; Pattern; Pediatric Psychology; Personal Satisfaction; Population; Position; Positioning Attribute; Prevalence; Professional Postions; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychologist; Psychotherapy, Cognitive; Public Health; Qualifying; Reading; Reporting; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Research Training; Researchers; Risk; Risk Factors; Role; Science of Medicine; Services; Sleep; Sleep Deprivation; Sleep disturbances; Sleep maintenance insomnia; Social support; Symptoms of depression; Systems, Health Care; Testing; Therapy, Cognition; Time; Training; Unemployment; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Center for Health Statistics; Unspecified Mental Disorder; Ventilator; Woman; Work; actigraphy; adult human (21+); angers; angry; brief intervention; care giver stress; care giving; career development; caregiver stress; caregiving; child developmental psychology; children; chronic disease/disorder; chronic disorder; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; depressive; depressive symptoms; design; designing; disability; disturbance in affect; executive control; executive function; experience; feelings; improved; intervention design; interventional strategy; jobless; joblessness; life span; lifespan; literature survey; loved ones; meetings; mental illness; mood alteration; mood and affect disturbance; mood disturbance; mood dysfunction; onset of sleep; out of work; pediatric; programs; psychologic; psychological; psychological disorder; psychosocial; public health medicine (field); resilience; skills; sleep onset; social role; social support network; therapy design; treatment design; unemployed; well-being; youngster","Sleep Depression, and Psychosocial Risk Factors in Caregivers",,77662,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,3,132902,
7755845,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH077924-03,,NIMH:168695;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DALLAS,UNITED STATES,PSYCHIATRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"SHAD, MUJEEB ;",8465517;,5K23MH077924,02/08/2008,01/31/2012,"Adherence; Adherence (attribute); Anterior; Area; Award; Awareness; Awareness of self; Awarenesses; Behavioral; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive; Data; Development; Dysfunction; Emergency medical service; Encephalon; Encephalons; Epidemiology; Forecast of outcome; Functional Magnetic Resonance Imaging; Functional disorder; Future; HOSP; Hospitalization; Image; International; Interruption; Intracellular Communication and Signaling; Investigators; Label; Lesion; Link; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Markers, Surrogate; Medial; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mentors; Modeling; Monitor; Motor; NIH RFA; NMR Imaging; NMR Tomography; Nervous System, Brain; Neurobiology; Nuclear Magnetic Resonance Imaging; Outcome; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Patients; Personal awareness; Phase; Physiopathology; Prefrontal Cortex; Prognosis; Programs (PT); Programs [Publication Type]; Psychoses; Psychotic Disorders; Reaction Time; Reporting; Request for Applications; Research; Research Personnel; Researchers; Response RT; Response Time; Sample Size; Schizophrenia; Schizophrenic Disorders; Self Perception; Self image; Self view; Signal Transduction; Signal Transduction Systems; Signaling; Social Functioning; Structure; Surrogate Markers; Symptoms; Testing; Training; WHO; World Health Organization; Zeugmatography; base; biological signal transduction; cingulate cortex; clinical relevance; clinical significance; clinically relevant; clinically significant; cognitive neuroscience; dementia praecox; design; designing; emergency service; fMRI; first episode schizophrenia; imaging; imaging modality; insight; neurobiological; outcome forecast; parietal cortex; pathophysiology; patient centered; patient oriented; programs; psychomotor reaction time; psychosocial; response; schizophrenic; self awareness; self knowledge; skills; statistics/biometry; treatment adherence; volunteer",Neurobiology of Insight Deficits in Schizophrenia,,77924,ITSP,"Interventions Committee for Disorders Related to Schizophrenia, Late Life, or Personality",,3,168695,
7762170,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH079214-03,,NIMH:179720;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"CHAN, EUGENIA ;",8620982;,5K23MH079214,02/05/2008,01/31/2012,"0-11 years old; AD/HD; ADHD; African American; Afro American; Afroamerican; American; Area; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavioral; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Black Populations; Black or African American; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Caring; Caryophyllus; Child; Child Youth; Children (0-21); Chinese American; Clinical; Cognitive; Communities; Confidentiality; Consensus; Consultations; Development; Diagnosis; Education; Educational aspects; Eugenia; European; Family; Focus Groups; Future; Goals; Health Care Providers; Health Personnel; Health Services; Healthcare Providers; Healthcare worker; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Intervention; Intervention Strategies; Interview; Investigators; K-Awards; K-Series Research Career Programs; Lead; Life Experience; Maintenance Therapy; Measurement; Measures; Mental Health; Mental Hygiene; Mentors; Methods; Modeling; Morbidity; Morbidity - disease rate; Outcome; PROV; Parents; Participant; Patient Care; Patient Care Delivery; Patients; Pb element; Prevention; Primary Care; Primary Health Care; Primary Healthcare; Principal Component Analyses; Principal Component Analysis; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Provider; Psychological Health; Psychometric; Psychometrics; QOC; QOL; Qualitative Methods; Quality Indicator; Quality of Care; Quality of life; Recommendation; Reporting; Research; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Risk; School Teachers; Structure; Survey Instrument; Surveys; Syzygium; Teachers, School; Testing; attention deficit hyperactive disorder; base; black American; children; clinical care; cost; cultural values; education planning; evidence base; experience; health care personnel; health care service; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; help seeking; help-seeking behavior; improved; instrument; interventional strategy; medical personnel; multidisciplinary; patient centered; patient oriented; patient population; pediatrician; privacy of information; programs; racial and ethnic disparities; skills; socioeconomic; socioeconomically; socioeconomics; statistics/biometry; treatment provider; willingness; youngster","A Cross-Cultural, Patient-Centered Approach for Assessing Quality of ADHD Care",,79214,SRNS,Mental Health Services in Non-Specialty Settings,,3,179720,
7772314,K23,MH,5,,03/01/2010,02/28/2011,,5K23MH079347-04,,NIMH:157663;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ROCHESTER,UNITED STATES,PSYCHIATRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"POLESHUCK, ELLEN L;",7838986;,5K23MH079347,03/01/2007,02/28/2012,"Adherence; Adherence (attribute); Affective Disorders; Award; Back Ache; Back Pain; Backache; Behavior Therapy, Cognitive; Behavioral Therapy; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Clinical; Cognitive Therapy; Consultations; Cranial Pain; Data; Depressed mood; Depression; Disadvantaged; Emotional Depression; Family Practice; Female Health; Foundations; Future; Gynecology; Head Pain; Headache; Individual; Internal Medicine; Intervention; Intervention Strategies; K23 Award; K23 Mechanism; K23 Program; Low income; Major Depressive Disorder; Manuals; Measures; Medical; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Minority; Mood Disorders; Outcome; Pain; Painful; Patients; Phase; Physical Function; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Procedures; Programs (PT); Programs [Publication Type]; Psychotherapy; Psychotherapy, Cognitive; Randomized Clinical Trials; Randomized Controlled Trials; Research; Research Activity; Risk; Sampling; Severities; Site Visit; Social Functioning; Symptoms of depression; Target Populations; Testing; Therapy, Cognition; Training; Trials, Randomized Clinical; Women's Health; care seeking; chronic pain; chronic painful condition; chronic pelvic pain; chronic pelvic pain syndrome; clinical practice; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; depressed; depressive; depressive symptoms; design; designing; disability; effective therapy; efficacy testing; family medicine; improved; interpersonal therapy; intervention design; interventional strategy; major depression; multidisciplinary; patient population; primary care setting; programs; psychosocial; randomized controlled study; response; sadness; satisfaction; secondary outcome; skills; therapy design; treatment adherence; treatment as usual; treatment design; woman health professional",Psychosocial Treatment for Gynecology Patients with Comorbid Depression and Pain,,79347,ITMA,Interventions Committee for Adult Mood and Anxiety Disorders,,4,157663,
7764654,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH080021-03,,NIMH:172194;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,HANOVER,UNITED STATES,PSYCHIATRY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"PRATT, SARAH ILANA;",7359917;,5K23MH080021,02/11/2008,01/31/2013,"21+ years old; Address; Adult; Affective Psychosis, Bipolar; Age; Aged 65 and Over; Anxiety; Area; Behavior; Bipolar Disorder; CMHC; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Caring; Characteristics; Clinical; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Communication; Communities; Community Mental Health Centers; Complement; Complement Proteins; Consumer Preferences; Curriculum; Depression; Development; Distal; Distress; Disturbance in cognition; Educational Curriculum; Effectiveness; Elderly; Elderly, over 65; Employment; Evaluation; FLR; Failure (biologic function); Friendships; Functional impairment; Geriatric Psychiatry; Goals; Human, Adult; Impaired cognition; Impairment; Independent Living; Individual; Institution; Institutionalization; Institutionalizations; Intervention; Intervention Strategies; Intervention Studies; Investigators; K-Awards; K-Series Research Career Programs; Learning; Left; Length of Life; Life; Literature; Living, Independent; Longevity; Major Depressive Disorder; Manuals; Measures; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mentorship; Methodology, Research; Methods and Techniques; Methods, Other; Modification; Mortality; Mortality Vital Statistics; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Nursing Homes; Onset of illness; Participant; Persons; Physical Health Services / Rehabilitation; Pilot Projects; Population; Preferences, Consumer; Process; Programs (PT); Programs [Publication Type]; Psychiatry for older adults; Psychiatry for older people; Psychiatry for seniors; Psychiatry for the elderly; Psychogeriatrics; Psychological Health; Psychological reinforcement; Psychosis, Manic-Depressive; Public Health; QOL; Quality of life; Randomized; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Reinforcement; Reinforcement (Psychology); Research; Research Career Program; Research Career Programs, K-Series; Research Design; Research Methodology; Research Methods; Research Personnel; Researchers; Risk; Role; Schizophrenia; Schizophrenic Disorders; Science of Statistics; Services; Social Functioning; Social isolation; Social support; Socialization; Socializations; Specific qualifier value; Specified; Statistical Methods; Statistics; Stigmata; Study Type; Symptoms; Techniques; Time; Training; Transportation; United States National Institute of Mental Health; Work; adult human (21+); advanced age; aged; base; bipolar affective disorder; career; cognitive dysfunction; cognitive loss; cognitively impaired; community living; dementia praecox; design; designing; disability; disease onset; disorder onset; elders; evidence base; experience; failure; functional disability; geriatric; geriatric psychology; geropsychiatry; geropsychology; geropsychopharmacology; improved; innovate; innovation; innovative; interventional strategy; late life; later life; life span; lifespan; major depression; manic depressive disorder; manic depressive illness; nursing home; older adult; older person; pilot study; pilot trial; preference; programs; psychosocial; psychosocial rehabilitation; public health medicine (field); randomisation; randomization; randomly assigned; rehabilitative; rural area; schizophrenic; senior citizen; serious mental illness; severe mental illness; skill acquisition; skills; skills training; social; social role; social stigma; social support network; statistics; stigma; study design; tool; treatment as usual",Individually Based Psychosocial Rehabilitation for Older People with SMI,,80021,SRSP,Mental Health Services in MH Specialty Settings,,3,172194,
7760077,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH082121-03,,NIMH:184353;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PHYSIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"JACOB, SUMA ;",1894679;,5K23MH082121,02/07/2008,01/31/2013,"0-11 years old; AVPR1; AVPR1A; AVPR1A gene; Adolescent; Adolescent Youth; Age; Antidiuretic Hormone; Antidiuretic Hormones; Applied Genetics; Argipressin; Assay; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Basic Research; Basic Science; Behavior; Bioassay; Biologic Assays; Biological Assay; Blood; Carboxypeptidase E; Causality; Chemotherapy-Hormones/Steroids; Chicago; Child; Child Psychiatry; Child Youth; Children (0-21); Clinical; Clinical Investigator; Clinical Research; Clinical Study; Communication; Data; Development; Diagnostic; Disease; Disorder; Doctor of Medicine; Doctor of Philosophy; Endocrine Gland Secretion; Enkephalin Convertase; Enkephalin-Forming Carboxypeptidase; Enkephalin-Synthesizing Carboxypeptidase; Enrollment; Environment; Enzyme Gene; Etiology; Female; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Variation; Genetic screening method; Genotype; Goals; Heterogeneity; Hormones; Human, Child; Illinois; Individual; Investigators; Kanner's Syndrome; Laboratories; Lead; M.D.; Mammals, Mice; Measures; Mentorship; Metabolic; Mice; Murine; Mus; Neurochemistry; Neurohormones; Neuropeptide Receptor; Neuropeptides; OXT; Ocytocin; Out-patients; Outpatients; Oxytocin; Pathway interactions; Patients; Pattern; Pb element; Peptide Receptor; Peptides; Peripheral; Ph.D.; PhD; Phenotype; Physiology; Population; Principal Investigator; Process; Processed Genes; Programs (PT); Programs [Publication Type]; Receptor Gene; Recombinant Oxytocin; Recruitment Activity; Research; Research Personnel; Researchers; Reticuloendothelial System, Blood; Risk; Role; SUBGP; Sampling; Science of neurochemistry; Social Behavior; Social Functioning; Social Interaction; Structure; Subgroup; Syndrome; System; System, LOINC Axis 4; Testing; Therapeutic Hormone; Training; Training of Investigators; Universities; Variant; Variation; Variation (Genetics); Vasopressin, 8-L-arginine-; Vasopressin, Arginine; Vasopressin-Neurophysin II-Copeptin; Vasopressins; allelic variant; alpha-amidating enzyme AE-II; association test; autism spectrum disorder; beta-Hypophamine; carboxypeptidase H; career development; children; clinical phenotype; cooking; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; enroll; genetic association; genetic technology; genetic testing; genetic variant; heavy metal Pb; heavy metal lead; improved; investigator training; juvenile; juvenile human; male; multidisciplinary; neurochemistry; pathway; peptidyl alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-amidating monooxygenase; peptidylglycine alpha-hydroxylating monooxygenase; peptidylglycine hydroxylase; peptidylglycine monooxygenase; peripheral blood; programs; recruit; restrictive repetitive behavior; sex; skills; social; social role; sociobehavior; sociobehavioral; tool; youngster",Autism: neuropeptide hormones and potential pathway genes,,82121,ZRG1,Special Emphasis Panel,,3,184353,
7787105,K23,MH,5,,01/01/2010,12/31/2010,PA-05-143,5K23MH082883-02,,NIMH:179219;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,GAINESVILLE,UNITED STATES,PSYCHIATRY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"KIM, SOO-JEONG ;",8864588;,5K23MH082883,03/13/2009,12/31/2012,"0-11 years old; Affect; Alleles; Allelomorphs; Analysis, Data; Animal Model; Animal Models and Related Studies; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Biological; Categories; Child; Child Psychiatry; Child Youth; Childhood; Children (0-21); Chromosomal Deletion; Chromosome Deletion; Chromosomes; Chronic; Clinical; Clinical Investigator; Closure by Ligation; Consultations; DISSEC; Data Analyses; Deliberate Self-Harm; Development; Development Plans; Discipline; Disease model; Dissection; Dose; Epidemiology; Ethics; Fostering; Foundations; Gene variant; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Diversity; Genetic Imprinting; Genetic Variation; Genomic Imprinting; Genotype; Goals; H2O syndrome; Haplotypes; Hereditary; Hereditary Disease; Human, Child; Individual; Inherited; Intervention; Intervention Strategies; Investigation; K23 Award; K23 Mechanism; K23 Program; Kanner's Syndrome; Labhart-Willi Syndrome; Labhart-Willi-Prader-Fanconi Syndrome; Ligation; Maternal uniparental disomy; Measures; Mental disorders; Mental health disorders; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentorship; Methods; Methylation; Molecular Disease; Molecular Genetic; Molecular Genetics; Obsession; Parental Imprinting; Parents; Partial Monosomy; Pathogenesis; Pattern; Plans, Development; Play; Prader-Labhart-Willi (PLW) syndrome (PLWS); Prader-Labhart-Willi syndrome; Prader-Labhart-Willi-Fanconi syndrome; Prader-Willi Syndrome; Prader-Willi syndrome (PWS); Predisposition; Protein Methylation; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Research; Research Design; Research Resources; Research Training; Resources; Risk; Role; SNP genotyping; Self-Injurious Behavior; Structure; Study Type; Susceptibility; Testing; Training; Unspecified Mental Disorder; Variation (Genetics); Work; allelic variant; autism spectrum disorder; base; cardiorespiratory syndrome of obesity in child; career development; children; cooking; deliberate self harm; design; designing; disorder model; genetic disorder; genetic variant; hereditary disorder; hypogenital dystrophy with diabetic tendency syndrome; hypotonia-hypogonadism-obesity syndrome; hypotonia-hypopigmentia-hypogonadism-obesity (HHHO) syndrome; hypotonia-hypopigmentia-hypogonadism-obesity syndrome; hypotonia-obesity-hypogonadism-mental retardation syndrome; imprint; insight; intentional self harm; intentional self injury; interest; interventional strategy; meetings; mental illness; model organism; neurobiological mechanism; novel; pediatric; proband; psychological disorder; public health relevance; self harm; self injury; skills; social role; stereotypy; study design; youngster",Genetic Dissection of Restricted Repetitive Behavior (RRB),,82883,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,2,179219,
7782762,K23,MH,5,,02/01/2010,01/31/2011,PA-05-143,5K23MH082997-02,,NIMH:172376;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DENVER,UNITED STATES,,01,093564180,US,CO,802044507,DENVER HEALTH AND HOSPITAL AUTHORITY,"KEELEY, ROBERT DENIUS;",8345961;,5K23MH082997,03/10/2009,01/31/2014,"Acute; Adherence; Adherence (attribute); Affective Disorders; Antidepressant Agent; Antidepressant Drugs; Antidepressant adherence; Antidepressants; Antidepressive Agents; Caring; Chronic; Clinical; Consultations; Counseling; Data; Depression; Development; Disease remission; Drug Therapy; Effectiveness; Emotional Depression; Evidence based treatment; Foundations; Guidelines; Individual; Intervention; Intervention Strategies; Interview; K23 Award; K23 Mechanism; K23 Program; Literature; Major Depressive Disorder; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mental Depression; Mental disorders; Mental health disorders; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Methods; Mood Disorders; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Outcome; Patients; Pharmacotherapy; Phase; Physicians; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Procedures; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; RMSN; Randomized Clinical Trials; Randomized Controlled Trials; Recovery; Relative; Relative (related person); Remission; Reporting; Research; Research Activity; Research Proposals; Risk; Sampling; Self Efficacy; Site Visit; Structure; Symptoms of depression; Testing; Therapeutic; Time; Training; Trials, Randomized Clinical; Underrepresented Minority; United States National Institute of Mental Health; Unspecified Mental Disorder; base; depressive; depressive symptoms; design; designing; disability; improved; interventional strategy; major depression; mental illness; motivational enhancement therapy; motivational interview; multidisciplinary; novel; primary care setting; programs; psychological disorder; psychosocial; randomized controlled study; secondary outcome; skills; therapeutic target; treatment adherence; under-represented minority; underserved minority",Motivational Interviews Adapted to Improve Depression Treatment in Primary Care,,82997,SRNS,Mental Health Services in Non-Specialty Settings,,2,172376,
7761286,K23,NR,5,,02/01/2010,01/31/2011,PA-05-143,5K23NR010747-02,,NINR:116366;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,PHILADELPHIA,UNITED STATES,NONE,02,002604817,US,PA,19104,DREXEL UNIVERSITY,"BLOCH, JOAN ROSEN;",8948980;,5K23NR010747,02/01/2009,01/31/2012,"Acculturation; Acculturations; Address; Affect; Behavioral; Birth; Birth Rate; Birth Records; CDC; Censuses; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinic; Complex; Country; Cultural Assimilation; Data; Development Plans; Disadvantaged; Education; Educational aspects; Enrollment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Funding; Future; Gestation; Goals; Health; Health Status; Health, Infant; Immigrant; Immigrations; In-Migration; Incidence; Individual; Individual Adjustment; Infant Health; Intervention; Intervention Strategies; Investigators; K23 Award; K23 Mechanism; K23 Program; Knowledge; Level of Health; Literature; Low Birth Weight Infant; Low income; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentors; Methodology, Research; Mexican; Mission; Neighborhoods; Outcome; Outcome Study; Parturition; Perinatal; Plans, Development; Population; Populations at Risk; Pregnancy; Premature Birth; Prenatal care; Preterm Birth; Programs (PT); Programs [Publication Type]; Records; Records, Birth; Reporting; Research; Research Methodology; Research Methods; Research Personnel; Research Priority; Researchers; Residencies; Risk; Risk Factors; SUBGP; Services; Socio-economic status; Socioeconomic Status; Status, Socioeconomic; Study, Outcome; Subgroup; Training; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; VLBW (human); Variant; Variation; Visit; Woman; base; behavioral health; black ethnic subgroup; black subgroup; career development; enroll; experience; health disparities; health disparity; improved; innovate; innovation; innovative; interventional strategy; low birth weight infant human; low birthweight; maternal stress; novel; perinatal health; premature childbirth; premature delivery; prenatal; preterm delivery; programs; protective effect; psychosocial; racial and ethnic; racial and ethnic disparities; racial/ethnic; racism; reproductive; skills; social; stressed mothers; unborn",Perinatal Health Disparities Between Foreign-born and US-born Black Women,,10747,NRRC,National Institute of Nursing Research Initial Review Group,,2,116366,
7797647,K23,NR,5,,02/01/2010,01/31/2011,PA-00-004,5K23NR010940-03,,NINR:117705;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,CHICAGO,UNITED STATES,MISCELLANEOUS,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"TANABE, PAULA ;",8077961;,5K23NR010940,02/20/2008,01/31/2011,"21+ years old; Accident and Emergency department; Acute Pain; Addictive Behavior; Address; Admission; Admission activity; Adult; Age; Analgesia Tests; Analgesic Agents; Analgesic Drugs; Analgesic Management; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Area; Biological; Caring; Complex; Complication; Comprehensive Health Care; Comprehensive Healthcare; Data Reporting; Discipline; Disease; Disorder; Doctor of Philosophy; Drugs; Education; Educational aspects; Emergencies; Emergency Department; Emergency Medicine; Emergency Situation; Emergency room; Evaluation; Feeling; Female; Frequencies (time pattern); Frequency; Genotype; Goals; HOSP; Hb SS disease; HbSS disease; Health Care Providers; Health Personnel; Health Services; Health Services Needs; Healthcare Providers; Healthcare worker; Hematology; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hospitalization; Hour; Human, Adult; Incidence; Individual; Interview; Investigators; Knowledge; Lead; Life; Life Expectancy; Medication; Medication Management; Mentorship; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Needs Assessment; Needs, Health Services; Nociception Tests; Nurses; Pain; Pain Assessment; Pain Control; Pain Measurement; Pain Therapy; Pain management; Painful; Paper; Pastoral Care; Patient Education; Patient Instruction; Patient Training; Patients; Pb element; Personnel, Nursing; Persons; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacologic Management; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physicians; Physiologic; Physiological; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Psychiatry; Psychometric; Psychometrics; Reporting; Reporting, Data; Research; Research Personnel; Researchers; Risk; Risk Factors; Sampling; Services; Sickle Cell; Sickle Cell Anemia; Social Health Services; Social Service; Social Work; Social work (field); Specialist; Techniques; Testing; Time; Training; United States; United States National Institutes of Health; Universities; Visit; addiction; adult human (21+); analgesia; career; career development; comprehensive care; disease/disorder; drepanocyte; drug addict; drug/agent; experience; feelings; health care personnel; health care service; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; hospital admission rate; improved; male; medical personnel; neglect; professor; programs; psychologic; psychological; satisfaction; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; social; tool; tool development; treatment provider",A Decision Support Tool for Adult Sickle Cell Emergency Department Patients,,10940,ZHL1,Special Emphasis Panel,,3,117705,
7775021,K23,NS,5,,02/01/2010,01/31/2011,PA-05-143,5K23NS059843-04,,NINDS:140207;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CINCINNATI,UNITED STATES,NEUROLOGY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"KHATRI, POOJA ;",8783664;,5K23NS059843,07/01/2007,01/31/2012,"Acute; Adverse Experience; Adverse event; Apoplexy; Arterial Obstruction; Arterial Occlusion; Arteries; Artery Obstruction; Benefits and Risks; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Bleeding; Blood - brain barrier anatomy; Blood Vessels; Blood flow; Blood-Brain Barrier; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cause of Death; Cerebral Stroke; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Cohort Studies; Concurrent Studies; Data; Development; Exposure to; Fear; Fellowship; Fibrinolytic Therapy; Fright; Future; Goals; Hemato-Encephalic Barrier; Hemorrhage; Hour; Infarction; Intracranial Hemorrhages; Intravenous; Investigators; Ischemic Stroke; K-Awards; K-Series Research Career Programs; Knowledge of Results; Knowledge of Results (Psychology); Mentors; Mentorship; Method LOINC Axis 6; Methodology; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural History; Outcome; Patients; Perception; Phase; Position; Positioning Attribute; Prevention strategy; Preventive strategy; Programs (PT); Programs [Publication Type]; Progress Review Group; Public Health; Publishing; R01 Mechanism; R01 Program; RPG; Reperfusion Therapy; Reporting; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk Factors; Role; Safety; Seminal; Site; Stroke; Strokes, Acute; Testing; Therapeutic Agents; Thrombolysis, Therapeutic; Thrombolytic Therapy; Time; Training; Translational Research; Translational Research Enterprise; Translational Science; United States; United States National Institutes of Health; Universities; Vascular Accident, Brain; Work; acute stroke; artery occlusion; base; blood loss; brain attack; cerebral vascular accident; clinical investigation; clinical significance; clinically significant; design; designing; disability; effective therapy; experience; improved; infarct; innovate; innovation; innovative; knowledge of results; novel; prevent; preventing; programs; public health medicine (field); reperfusion; skills; social role; statistics/biometry; stroke; stroke therapy; success; translation research enterprise; vascular",The Significance of Intracranial Hemorrhage after Revascularization Therapy,,59843,NST,Training Grant and Career Development Review Committee,,4,140207,
7771792,K24,AI,5,,03/01/2010,02/28/2011,PA-04-107,5K24AI068903-05,,NIAID:167787;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"VINETZ, JOSEPH M.;",1949775;,5K24AI068903,03/01/2006,02/28/2011,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acute suppurative arthritis due to bacteria; Affect; American; Area; Award; Bacterial Arthritis; Basic Research; Basic Science; Biochemical; Biography; C. difficile; C.difficile; California; Case Fatality Rates; Case Study; Cessation of life; Clinical; Clinical Faculty; Clinical Investigator; Clinical Nurse Educator; Clinical Parasitology; Clinical Research; Clinical Study; Clostridium difficile; Colitis; Commit; Common Rat Strains; Communicable Diseases; Communicable Diseases, Emerging; Country; Culicidae; Death; Delayed Hypersensitivity; Delayed-Type Hypersensitivity; Developing Countries; Developing Nations; Development; Development Plans; Disease; Disease Outcome; Disorder; Emerging Communicable Diseases; Endemic Diseases; Environment; Epidemiology; Faculty; Faculty, Nursing; Falciparum Malaria; Fellowship; Fertility/Fertilization; Fertilization; Foundations; Funding; Future; Genetic; Genetic Determinism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetics, Human; Genomics; Goals; Grant; Hand; Health; History of Medicine; Human; Human Genetics; Human, General; Hygiene; Immune response; Immunity; Immunologic Deficiency Syndrome, Acquired; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases / Laboratory; Infectious Diseases Research; Infectious Diseases and Manifestations; Infectious Diseases, Emerging; Infectious Disorder; Inherited Predisposition; Inherited Susceptibility; Institutes; Internal Medicine; International; Intramural Program; Intramural Research Program; Investigation; Investigators; Journals; Junior Physician; K24 Award; K24 Mechanism; K24 Program; Laboratories; Latin America; Lead; Leptospirosis; Less-Developed Countries; Less-Developed Nations; Magazine; Malaria; Malaria, Falciparum; Mammals, Rats; Man (Taxonomy); Man, Modern; Medical; Medical Students; Medicine; Mentors; Microarray Analysis; Microarray-Based Analysis; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Midcareer Investigator Award in Patient-Oriented Research (K24); Molecular; Mosquitoes; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nurse Educator; Nursing Faculty; Nursing Staff Developer; Nursing Staff Development Specialist; Outcome; Paludism; Paper; Parasites; Parasitic Diseases; Patients; Pb element; Peer Review; Peru; Physician, Junior; Physicians; Plans, Development; Plasmodium Infections; Plasmodium falciparum; Plasmodium falciparum Malaria; Plasmodium vivax; Polymorphism Analysis; Polymorphism Detection; Polymorphism, Single Base; Population; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Predisposition; Preparation; Prevention; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Public Health; Publications; Publishing; Pyogenic Arthritis; R01 Mechanism; R01 Program; RPG; Rat; Rates, Case Fatality; Rattus; Recruitment Activity; Research; Research Associate; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Research Training; Researchers; SNP; SNPs; Scholarship; Schools, Medical; Schools, Veterinary; Science; Science of Medicine; Scientific Publication; Scientist; Septic Arthritis; Single Nucleotide Polymorphism; Site; Students; Students, Medical; Supervision; Susceptibility; Systems Biology; Testing; Texas; Third-World Countries; Third-World Nations; Time; Training; Training Programs; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Transmission; Tropical Disease; Tropical Medicine; Tuberculin-Type Hypersensitivity; Type IV Hypersensitivity; Under-Developed Countries; Under-Developed Nations; United States; United States National Institutes of Health; Universities; Vaccines; Veterinary Schools; Work; anthropogenesis; anthropogenic; association test; base; bench bed side; bench bedside; bench to bed side; bench to bedside; career; career development; case report; cell mediated hypersensitivity; delayed-type hypersensitivity response; design; designing; disease/disorder; experience; experiment; experimental research; experimental study; field study; genetic association; genetic determinant; genetic etiology; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; host response; immunoresponse; improved; insight; language translation; man; man's; medical schools; member; microarray technology; new approaches; novel approaches; novel strategies; novel strategy; parasite invasion; patient centered; patient oriented; patient oriented research; patient oriented study; post-doc; post-doctoral; prisma; professor; programs; public health medicine (field); recruit; research study; skills; success; translation research enterprise; transmission process",Patient-Oriented Research in Tropical Infectious Diseases,,68903,MID,Microbiology and Infectious Diseases Research Committee,,5,167787,
7765512,K24,AI,5,,02/01/2010,01/31/2011,PA-04-107,5K24AI080942-02,,NIAID:182169;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LAUTENBACH, EBBING ;",6411068;,5K24AI080942,02/15/2009,01/31/2014,"Alimentary Canal; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antimicrobial Resistance; Antimicrobial resistant; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Clinical; Clinical Investigator; Clinical Research; Clinical Study; Clinical and Translational Science Awards; Cohort Studies; Commit; Communicable Diseases; Concurrent Studies; Development; Digestive Tract; E coli; Environment; Epidemiology; Escherichia coli; Escherichia coli Infections; Evolution; Funding; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Grant; Human; Human, General; Individual; Infections, E coli; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infrastructure; Instruction; Intervention; Intervention Strategies; Investigators; K24 Award; Laboratories; Long-Term Care; Man (Taxonomy); Man, Modern; Master of Science; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Miscellaneous Antibiotic; Organism; Pathogenicity Factors; Pathway interactions; Patients; Peer Review; Pennsylvania; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Infrastructure; Research Personnel; Research Training; Researchers; Resistance; Resistance to antibiotics; Resistance to antimicrobial; Resistance, Antibiotic; Resistant to antibiotics; Role; Schools, Medical; Science of Medicine; Study models; Time; Training; Training Programs; Universities; Virulence Factors; alimentary tract; anti-microbial resistance; anti-microbial resistant; antibiotic resistant; clinical epidemiology; cohort; data management; digestive canal; driving force; extended care; fluoroquinolone resistance; innovate; innovation; innovative; interventional strategy; living system; medical schools; next generation; pathway; patient centered; patient oriented; patient oriented research; patient oriented study; professor; programs; prospective; resistance to anti-microbial; resistant; resistant to anti-microbial; resistant to antimicrobial; social role; statistics/biometry",Mentoring and patient-oriented research in antimicrobial resistance,,80942,MID,Microbiology and Infectious Diseases Research Committee,,2,182169,
7764728,K24,DK,5,,01/01/2010,12/31/2010,PA-04-107,5K24DK062849-08,,NIDDK:173520;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"IKIZLER, TALAT ALP;",2024286;,5K24DK062849,03/01/2003,12/31/2012,"Achievement; Achievement Attainment; Acute; Agonist; American; Amino Acids; Autoregulation; Book Chapters; COX-2; COX2; Chapters, Book; Chronic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Death Rate; Development; Dialysis patients; Disease; Disorder; EXTMR; Extramural; Extramural Activities; Faculty; Funding; Future; Goals; Grant; HOSP; Hemodialyses; Hemodialysis; Homeostasis; Hospitalization; INFLM; Inflammation; Inflammatory Response; Institution; Insulin Resistance; Intermediary Metabolism; Journals; K24 Mechanism; K24 Program; Kidney Diseases; Lead; METBL; Magazine; Manuscripts; Master of Science; Mediating; Medical Students; Medicine; Mentors; Metabolic; Metabolic Processes; Metabolism; Midcareer Investigator Award in Patient-Oriented Research; Midcareer Investigator Award in Patient-Oriented Research (K24); Mission; Modeling; Muscle Proteins; Names; Nephrology; Nephropathy; Nutrition; Nutritional; Nutritional Science; Nutritional status; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Patients; Pb element; Peer Review; Physiologic; Physiological; Physiological Homeostasis; Process; Programs (PT); Programs [Publication Type]; Proteins; Publishing; R01 Mechanism; R01 Program; RPG; Randomized Controlled Trials; Renal Disease; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Science of Medicine; Science of nutrition; Secure; Societies; Students, Medical; Supplementation; Testing; Training; Translational Research; Translational Research Enterprise; Translational Science; aminoacid; career; clinical investigation; clinical practice; disease/disorder; gene product; hCOX-2; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; insulin resistant; insulin sensitivity; kidney disorder; methyl butyrate; novel; nutrition; patient oriented research; patient oriented study; programs; randomized controlled study; renal disorder; success; translation research enterprise; wasting",Nutrition and Metabolism in Dialysis Patients,,62849,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,8,173520,
7763241,K24,HL,5,,02/01/2010,01/31/2011,PA-04-107,5K24HL086796-04,,NHLBI:161503;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"SCHNAPP, LYNN M;",1886734;,5K24HL086796,02/13/2007,01/31/2012,"ARDS; ARDS, Human; ARDSs, Human; Acute Pulmonary Injury; Adult RDS; Adult Respiratory Distress Syndrome; Arts; Award; Biochemical; Biochemical Markers; Blood Serum; Bronchoalveolar Lavage Fluid; Critical Illness; Critically Ill; Curriculum; Development; Diagnosis; Diagnostic; Educational Curriculum; Environment; Faculty; Funding; Goals; Immune response; Infection; Infrastructure; Investigators; K12 Mechanism; K12 Program; Leadership; Lung; Lung Injury, Acute; Markers, Biochemical; Measurement; Mediator; Mediator of Activation; Mediator of activation protein; Mentored Clinical Scientist Development Program; Mentors; Method LOINC Axis 6; Methodology; Microbiology; Modality; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Outcome; P. aeruginosa; P.aeruginosa; Pathway interactions; Patients; Physician Scientist Award (Program); Physicians; Pneumology; Pneumonia; Pneumonitis; Pneumonology; Predictive Value; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Public Health Schools; Pulmonary Disease (Specialty); Pulmonary Inflammation; Pulmonary Medicine; Pulmonology; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Role; S. aureus; S.aureus; Schools, Public Health; Science of Microbiology; Serum; Severities; Severity of illness; Shock Lung; Staphylococcus aureus; Time; Training; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Universities; Ventilator; Washington; acute lung injury; base; biomarker; disease severity; gene product; high risk; host response; immunoresponse; improved; insight; lung injury; new therapeutics; next generation therapeutics; novel therapeutics; pathway; patient centered; patient oriented; patient oriented research; patient oriented study; programs; protein profiling; pulmonary; social role; translation research enterprise",Proteomic-based Approach to Ventilator Associated Pneumonia,,86796,ZHL1,Special Emphasis Panel,,4,161503,
7755862,K24,NS,5,,02/01/2010,01/31/2011,PA-04-107,5K24NS051400-05,,NINDS:169668;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RANSOHOFF, RICHARD M;",1864157;,5K24NS051400,02/08/2006,01/31/2011,"Address; Anatomic; Anatomical Sciences; Anatomy; Antibodies; Attention; Biological Models; Blood - brain barrier anatomy; Blood leukocyte; Blood monocyte; Blood-Brain Barrier; Body Tissues; Brain; Cells; Central Nervous System; Characteristics; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cytokines, Chemotactic; Data; Development; Disease; Disorder; Encephalon; Encephalons; Evolution; Familiarity; Generations; Goals; Hemato-Encephalic Barrier; Homologous Chemotactic Cytokines; Hortega cell; INFLM; Image; Inflammation; Inflammatory; Intercrines; Investigators; Lesion; Leukocyte Trafficking; Leukocytes; MR Imaging; MR Tomography; MRI; MS (Multiple Sclerosis); MS Lesions; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Marrow leukocyte; Marrow monocyte; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mentors; Mentorship; Methodology, Research; Microglia; Model System; Models, Biologic; Multiple Sclerosis; Multiple Sclerosis Lesions; NMR Imaging; NMR Tomography; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurologic; Neurological; Nuclear Magnetic Resonance Imaging; Patients; Pattern; Phase; Programs (PT); Programs [Publication Type]; Receptor Protein; Regulation; Research; Research Methodology; Research Methods; Research Personnel; Research Technics; Researchers; Reticuloendothelial System, Leukocytes; SIS cytokines; Science of Anatomy; Scientist; Sclerosis, Disseminated; Series; Staging; T-Cells; T-Lymphocyte; Techniques, Research; Testing; Thymus-Dependent Lymphocytes; Tissues; United States; White Blood Cells; White Cell; Zeugmatography; anatomy; base; biomarker; chemoattractant cytokine; chemokine; chemokine receptor; clinical investigation; clinical practice; disability; disease/disorder; gitter cell; human disease; imaging; in vitro Model; in vivo; insight; insular sclerosis; mesoglia; microglial cell; microgliocyte; monocyte; natalizumab; novel; perivascular glial cell; programs; receptor; receptor expression; receptor function; selective expression; selectively expressed; small molecule; thymus derived lymphocyte; trafficking; white blood cell; white blood corpuscle",Chemokine Regulation on Central Nervous System Inflammation in Multiple Sclerosis,,51400,NST,Training Grant and Career Development Review Committee,,5,169668,
7796861,K25,CA,5,,03/01/2010,02/28/2011,PA-06-087,5K25CA123344-03,,NCI:146880;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"LIANG, SHOUDAN ;",8474886;,5K25CA123344,03/07/2008,02/28/2013,"ATGN; Adjuvant Therapy; Adoptive Transfer; Adverse effects; Allele Frequency; Allo BMT; Allogeneic BMT; Allogeneic Bone Marrow Transplantation; Allogenic; Antigenic Determinants; Antigens; Assay; Banking, Tissue; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood; Blood (Leukemia); Blood Sample; Blood specimen; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; CTL; Cancer Center; Cancer Immunology Science; Cancer Radiotherapy; Cancer Treatment; Cancers; Cell Therapy; Cell-Mediated Cytolysis; Cell-Mediated Lympholysis; Cell-Mediated Lympholytic Cells; Cells; Cellular Cytotoxicity; Characteristics; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Collection; Complement; Complement Proteins; Complication; Cytolysis; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxicity, Immunologic; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disease remission; Disorder; Effectiveness; Environment; Epitopes; GVHD; GWAS; Gene Frequency; General Population; General Public; Genes; Genetic; Genetic Polymorphism; Genotype; Graft Material; Graft-Versus-Host Disease; Graft-vs-Host Disease; Grafting, Bone Marrow; HL-A Antigens; HLA Antigens; Hematopoietic; Homologous Wasting Disease; Human Leukocyte Antigens; ITX; Immune response; Immune system; Immunologically Directed Therapy; Immunotherapy; Investigation; Investigators; Knowledge; Laboratories; Lead; Legal; Leukemias, General; Leukocyte Antigens; Link; Lymphocyte; Lymphocyte Cytotoxicity; Lymphocytic; Lymphocytotoxicity; Lysis; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Marrow Transplantation; Measures; Mediating; Methods; Methods and Techniques; Methods, Other; Minor Histocompatibility Antigens; Minor Histocompatibility Peptides; Mission; Molecular Interaction; Mother Cells; Outcome; Patient Care; Patient Care Delivery; Patients; Pattern; Pb element; Peptides; Physicians; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; RMSN; Radiation therapy; Radiotherapeutics; Radiotherapy; Reaction; Recurrent disease; Relapse; Relapsed Disease; Remission; Research; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Runt Disease; SNP; SNPs; Sampling; Screening procedure; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism in Coding Sequence; Single Nucleotide Polymorphisms in cDNA Sequences; Specificity; Stem cells; T-Cells; T-Lymphocyte; T-Lymphocytes, Cytotoxic; Techniques; Testing; Therapeutic; Therapy, Cell; Therapy, Vaccine; Thymus-Dependent Lymphocytes; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Translating; Translatings; Transplantation; Transplanted tissue; Treatment Side Effects; VAC-TX; Vaccinated; Vaccination; Vaccine Therapy; Vaccines; Work; allelic frequency; anticancer therapy; antigen binding; body system, allergic/immunologic; cSNP; cancer immunology; cancer therapy; cell mediated cytotoxicity; cell-based therapy; chemotherapy; clinical care; clinical data repository; clinical data warehouse; clinical effect; clinical investigation; clinical relevance; clinically relevant; cohort; data repository; disease/disorder; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; host response; immune therapy; immunogen; immunogenic; immunoresponse; improved; irradiation; language translation; leukemia; lymph cell; malignancy; neoplasm/cancer; organ system, allergic/immunologic; patient population; polymorphism; prevent; preventing; programs; relational database; sample collection; screening; screenings; side effect; specimen collection; therapy adverse effect; thymus derived lymphocyte; transplant; treatment adverse effect; whole genome association studies; whole genome association study",Genome-wide Identification of Minor Histocompatibility Antigens,,123344,NCI,Subcommittee E - Prevention & Control,,3,146880,
7758757,K25,HL,5,,02/01/2010,01/31/2011,PA-06-087,5K25HL086713-04,,NHLBI:106299;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"ALESSIO, ADAM M;",8544294;,5K25HL086713,02/01/2007,01/31/2012,"Address; Algorithms; Anatomic; Anatomical Sciences; Anatomy; Angiogram; Angiography; Artifacts; Arts; Atomic Medicine; Biomedical Engineering; Blood flow; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cardiac; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Clinical; Clinical Protocols; Complement; Complement Proteins; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary heart disease; Data; Detection; Development; Diagnosis; Diagnostic; Discipline of Nuclear Medicine; Disease; Disorder; Dose; EMI scan; Ensure; Environment; Event; Faculty; Generations; Image; Image Reconstructions; Imaging Procedures; Imaging Techniques; Intermediary Metabolism; Investigators; Ischemia; Lead; METBL; Measurement; Medical Imaging, Positron Emission Tomography; Mentors; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Modeling; Morphologic artifacts; Motion; Movement; Msec; Myocardial; Myocardial perfusion; Needs Assessment; Noise; Nuclear; Nuclear Medicine; Organ System, Cardiovascular; PET; PET Scan; PET imaging; PETSCAN; PETT; Patients; Pb element; Phase; Photons; Physics; Positron Emission Tomography Scan; Positron-Emission Tomography; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Radiology; Radiology / Radiation Biology / Nuclear Medicine; Radiology Specialty; Radiology, General; Radiology-Nuclear Medicine; Reconstructions, Image; Research; Research Personnel; Researchers; Resolution; Role; Science of Anatomy; Science of Statistics; Solutions; Statistics; System; System, LOINC Axis 4; Tag; Technics, Imaging; Techniques; Tissue Viability; Tomodensitometry; Tomography, Computed, Scanners; Tomography, Xray Computed; Tracer; Training; Training Activity; Universities; Vascular, Heart; Viability, Tissue; Washington; X-Ray Computed Tomography; anatomy; attenuation; base; bioengineering; bioengineering/biomedical engineering; bioimaging; bioimaging/biomedical imaging; biomedical imaging; body movement; cardiac motion; cardiac scanning; cardiovascular function; career; catscan; circulatory system; computed axial tomography; computerized axial tomography; computerized tomography; coronary disorder; design; designing; disease/disorder; experience; heart imaging; heart motion; heart scanning; heavy metal Pb; heavy metal lead; image processing; imaging; imaging modality; improved; insight; member; millisecond; programs; reconstruction; respiratory; social role; statistics; uptake",Quantitative Cardiac PET/CT Imaging,,86713,ZHL1,Special Emphasis Panel,,4,106299,
7920157,K25,NS,5,,01/01/2010,12/31/2010,PA-02-127,5K25NS053544-05,,NINDS:114306;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SALT LAKE CITY,UNITED STATES,BIOMEDICAL ENGINEERING,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"DORVAL, ALAN D;",8248418;,5K25NS053544,01/01/2006,12/31/2010,"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-Hydroxydopamine; 6-OHDA; Abscission; Adverse effects; Affect; Animals; Area; Award; Basal Ganglia; Basal Nuclei; Behavior; Benign Essential Tremor; Biological; Biological Neural Networks; Bradykinesia; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Clinical; Clinical Data; Collaborations; Common Rat Strains; Computer Simulation; Computerized Models; Corpus Striatum; Corpus striatum structure; Data; Deep Brain Stimulation; Development; Disease; Disease model; Disorder; Drugs, Nonproprietary; Electrodes; Encephalon; Encephalons; Engineering; Engineerings; Entropy; Essential Tremor; Excision; Exposure to; Extirpation; Foundations; Frequencies (time pattern); Frequency; Funding; Future; Generic Drugs; Grant; History; Idiopathic Parkinson Disease; Implant; Individual; Information Theory; Intracellular Communication and Signaling; Investigators; Knowledge; Laboratories; Learning; Lesion; Lewy Body Parkinson Disease; Light; Link; MPTP; Macaca mulatta; Mammals, Primates; Mammals, Rats; Mammals, Rodents; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mentors; Methods and Techniques; Methods, Other; Misinformation; Modeling; Models, Computer; Monitor; Motor; Motor output; Muscle; Muscle Tissue; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Noise; Nucleus Subthalamicus; Onset of illness; Operation; Operative Procedures; Operative Surgical Procedures; Output; Oxidopamine; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Pattern; Photoradiation; Physiologic pulse; Position; Positioning Attribute; Pressure; Pressure- physical agent; Primary Parkinsonism; Primates; Programs (PT); Programs [Publication Type]; Publishing; Pulse; Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-; Rat; Rattus; Recording of previous events; Removal; Research; Research Personnel; Researchers; Rhesus; Rhesus Macaque; Rhesus Monkey; Rodent; Rodentia; Rodentias; Rotation; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Sound; Sound - physical agent; Striate Body; Striatum; Structure of subthalamic nucleus; Subthalamic Nucleus; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Symptoms; Techniques; Testing; Thalamic structure; Thalamus; Time; Treatment Side Effects; Tremor; Universities; Visual; Work; base; biological signal transduction; career development; clinical efficacy; computational modeling; computational models; computational simulation; computer based models; computerized data processing; computerized modeling; computerized simulation; data processing; design; designing; disease onset; disease/disorder; disorder model; disorder onset; effective therapy; experience; generic; improved; in silico; information processing; methylphenyltetrahydropyridine; motor disease; motor disorder; nervous system disorder; neural; neural network; neurological disease; neuronal; novel; pressure; programs; relating to nervous system; resection; response; side effect; signal processing; skills; sound; striatal; surgery; thalamic; therapy adverse effect; tool; treatment adverse effect; virtual simulation",Career Development in the Mechanisms of Deep Brain Stimulation,,53544,NST,Training Grant and Career Development Review Committee,,5,114306,
7763868,K99,DK,5,,02/01/2010,01/31/2011,PA-07-297,5K99DK080945-02,,NIDDK:90000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"ZRAIKA, SAKENEH ;",9080993;,5K99DK080945,02/05/2009,01/31/2011,"Address; Angiotensin I; Angiotensins; Antigens, Leukemia, Common Acute Lymphoblastic; Atriopeptidase; Award; B9 endocrine pancreas; Beta Cell; Body Tissues; Brain; CALLA Antigen; CD10 Antigens; Carbohydrates; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chronic; Chronic Disease; Chronic Illness; Common ALL Antigen; D-Glucose; Data; Death; Defect; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Dysfunction; Encephalon; Encephalons; Endopeptidase-24.11; Enkephalin Dipeptidyl Carboxypeptidase; Enkephalinase; Enkephalinase-24.11; Esteroproteases; Evaluation; Exocrine pancreas; FLR; Failure (biologic function); Fats; Fatty Acids, Nonesterified; Fatty acid glycerol esters; Free Fatty Acids; Functional disorder; Funding; Glucose; Goals; Health; Hour; Humulin R; Hyperglycemia; Hyperlipemia; Hyperlipidemia; Impairment; In Vitro; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Intravenous; Investigators; Islands of Langerhans; Islet Cells; Islets of Langerhans; Kidney; Kidney-Brush-Border Neutral Proteinase; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Mediating; Membrane Metallo-Endopeptidase; Membrane Metalloendopeptidase; Mentors; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Modeling; Murine; Mus; NIDDM; Neprilysin; Nervous System, Brain; Nesidioblasts; Neutral Endopeptidase; Neutral Endopeptidase 24.11; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Novolin R; Outcome; Oxidative Stress; Oxidative Stress Induction; Pancreas, Endocrine; Pancreatic Islets; Pancreatic beta Cell; Pars endocrina pancreatis; Pathway interactions; Peptidases; Peptide Hydrolases; Peptides; Phase; Physiopathology; Play; Production; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Renin-Angiotensin System; Research; Research Personnel; Research Support; Researchers; Role; Salaries; Structure of beta Cell of islet; Subcellular Process; T2D; T2DM; Testing; Thermolysin-Like Metalloendopeptidase; Tissues; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; Wages; YGG-Forming Enzyme; adult onset diabetes; base; beta cell development; chronic disease/disorder; chronic disorder; cytotoxic; diabetes; endocrine pancreas; endocrine pancreas development; experience; experiment; experimental research; experimental study; failure; fat metabolism; feeding; gene product; hyperglycemic; in vivo; insulin secretion; interest; islet; islet development; islet progenitor; ketosis resistant diabetes; kidney brush border neutral peptidase; lipid metabolism; maturity onset diabetes; pancreas beta cell; pathophysiology; pathway; prevent; preventing; programs; renal; research study; response; social role; stressor; therapeutic development",The role of neprilysin in pancreatic beta-cell dysfunction and death,,80945,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,2,90000,
7760075,K99,EY,5,,01/01/2010,12/31/2010,PA-07-297,5K99EY018894-02,,NEI:91436;,2010,NATIONAL EYE INSTITUTE,,PITTSBURGH,UNITED STATES,NEUROSCIENCES,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SMITH, MATTHEW A;",7896679;,5K99EY018894,01/15/2009,12/31/2010,"Animals; Area; Area striata; Area striata structure; Attention; Cell Communication and Signaling; Cell Signaling; Code; Coding System; Complex; Cortex, Striate; Data; Electrodes; Eye; Eye Movements; Eyeball; Feedback; Goals; Implant; Individual; Intracellular Communication and Signaling; Investigators; Macaca; Macaque; Measures; Motor; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Output; Pathway interactions; Pattern; Photic Stimulation; Physiologic; Physiological; Play; Population; Primary visual cortex; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pursuit, Saccadic; Research; Research Personnel; Researchers; Role; Saccades; Saccadic Eye Movements; Shapes; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Striate area; Structure; Synapses; Synaptic; Testing; Transmission; V4 neuron; Vision; Visual; Visual Cortex; Visual Stimulation; Visual System; Visual system structure; area V1; area V4; area striata; attentional modulation; base; biological signal transduction; experiment; experimental research; experimental study; extracellular; extrastriate visual cortex; frontal eye fields; inferotemporal cortex; insight; neural; neuronal; pathway; programs; receptive field; relating to nervous system; research study; response; social role; transmission process; visual cortical",Influence of attention and eye movement signals on population coding in area V4,,18894,ZEY1,Special Emphasis Panel,,2,91436,
7807884,M01,RR,5,,12/01/2009,11/30/2010,,5M01RR000865-37,,NCRR:4124587;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"WASHINGTON, A EUGENE;",1959100;,5M01RR000865,02/03/1997,11/30/2011,,General Clinical Research Center,,865,ZRR1,Special Emphasis Panel,,37,4124587,
7749023,M01,RR,5,,12/01/2009,11/30/2010,,5M01RR000997-35,,NCRR:3115266;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,ALBUQUERQUE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"LARSON, RICHARD S;",1929112;,5M01RR000997,02/10/1997,11/30/2010,,University of New Mexico - General Clinical Research Center,,997,RIRG,National Center for Research Resources Initial Review Group,,35,3115266,
7848132,P01,AG,5,,02/01/2010,11/30/2010,,5P01AG009973-18,,NIA:1677836;,2010,NATIONAL INSTITUTE ON AGING,,BALTIMORE,UNITED STATES,PSYCHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GALLAGHER, MICHELA ;",1882110;,5P01AG009973,09/01/1997,11/30/2012,,Cognition and Hippocampal/Cortical Systems in Aging,,9973,ZAG1,Special Emphasis Panel,,18,1677836,
8018578,P01,AG,5,,,,,5P01AG009973-18,0010,,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,,08,049435266,US,MA,02215,JOHNS HOPKINS UNIVERSITY,"EICHENBAUM, HOWARD B.;",1875153;,5P01AG009973,,,"Age; Age-associated cognitive decline; Age-associated memory impairment; Age-related cognitive decline; Aging; Ammon Horn; Animals; Appearance; Area; Behavior; Behavioral; Benign senescent forgetfulness; Biological; Cells; Code; Coding System; Cognition; Cognitive Disturbance; Cognitive Impairment; Cognitive aging; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Confusion; Confusional State; Cornu Ammonis; Development; Disturbance in cognition; Drugs; Entorhinal Area; Entorhinal Cortex; Environment; Episodic memory; Episodic memory, function; Exhibits; FLR; Failure (biologic function); Familiarity; Funding; Goals; Hippocampus; Hippocampus (Brain); Hydrogen Oxide; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Impaired cognition; Impairment; Lateral; Mammals, Rats; Maze Learning; Measures; Medication; Memory; Memory Deficit; Memory impairment; Mental Confusion; Muscle Rigidity; Nature; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Odors; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Rat; Rattus; Recognition (Psychology); Retrieval; Rigidity; Rigidity, Muscular; Rodent Model; Science of neurophysiology; Senescence; Signal Detection (Psychology); Signal Detection Analyses; Signal Detection Analysis; Signal Detection Theory; Structure of entorhinal cortex; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Agents; Water; adult youth; age dependent; age effect; age related; aged; aging effect; base; cognitive dysfunction; cognitive loss; cognitively impaired; design; designing; drug/agent; entorhinal cortex; experience; experiment; experimental research; experimental study; failure; hippocampal; improved; juvenile animal; loss of function; memory recognition; memory retrieval; neural; neuronal; neurophysiology; novel; programs; relating to nervous system; research study; senescent; success; young adult; young animal",FUNCTIONAL CODING IN HIPPOCAMPAL/CORTICAL SYSTEMS,,9973,ZAG1,Special Emphasis Panel,,18,,265711
8018579,P01,AG,5,,,,,5P01AG009973-18,0011,,2010,NATIONAL INSTITUTE ON AGING,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GALLAGHER, MICHELA ;",1882110;,5P01AG009973,,,"2 propylvalerate; Age; Aging; Agonist; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Anti-epileptic; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Area; Behavioral; Biologic Marker; Biological Markers; Brain; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Cornu Ammonis; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dentate Fascia; Dentate Gyrus; Disturbance in cognition; Dysfunction; Encephalon; Encephalons; Entorhinal Area; Entorhinal Cortex; Environment; Exhibits; Expression Profiling; Expression Signature; Fascia Dentata; Functional disorder; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Genome; Gyrus Dentatus; HDAC Agent; HSP; Heat shock proteins; Hippocampal Formation; Hippocampus; Hippocampus (Brain); Histone Deacetylase Inhibitor; Human; Human, General; Impaired cognition; Impairment; In Vitro; Individual Differences; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Learning; Macaca mulatta; Mammals, Primates; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Medial; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Molecular Fingerprinting; Molecular Marker; Molecular Profiling; Monkeys; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocognitive; Neurocyte; Neurons; Outcome; Oxidative Stress; Pathway interactions; Pattern; Perforant Path; Perforant Pathway; Perforating Fasciculus; Performance; Physiopathology; Population; Population Study; Primates; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Quality Control; RNA Expression; Rat; Rattus; Reading; Receptor Protein; Recruitment Activity; Relative; Relative (related person); Research; Rhesus; Rhesus Macaque; Rhesus Monkey; Rodent; Rodentia; Rodentias; Screening procedure; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Signature Molecule; Sodium Butyrate; Stress Proteins; Structure of dentate gyrus; Structure of entorhinal cortex; Subcellular Process; Synaptic plasticity; System; System, LOINC Axis 4; Temporal Lobe; Testing; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Translations; Treatment Efficacy; Up-Regulation; Work; adult youth; aged; base; biological signal transduction; biomarker; brain tissue; butyric acid, sodium salt; clinical data repository; clinical data warehouse; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; data repository; dentate gyrus; entorhinal cortex; experiment; experimental research; experimental study; hippocampal; hippocampal subregions; improved; interventional strategy; life history; microarray technology; mid life; mid-life; middle age; middle aged; midlife; model organism; molecuar profile; molecular signature; neurobiological; neuronal; novel; pathophysiology; pathway; programs; protein folding; receptor; recruit; relational database; research study; response; screening; screenings; senescent; sodium butanoate; stress protein; synapse failure; synaptic failure; temporal cortex; temporal lobe/cortex; therapeutic efficacy; therapeutically effective; treatment effect; valproate; young adult",ANIMAL MODELS AND FUCNTIONAL CHANGES IN AGING,,9973,ZAG1,Special Emphasis Panel,,18,,339491
8018580,P01,AG,5,,,,,5P01AG009973-18,0012,,2010,NATIONAL INSTITUTE ON AGING,,NEW YORK,UNITED STATES,,14,078861598,US,NY,100296574,JOHNS HOPKINS UNIVERSITY,"RAPP, PETER R;",1864386;,5P01AG009973,,,"2 propylvalerate; 21+ years old; Accounting; Adaptive Behaviors; Address; Adult; Affect; Age; Age-associated cognitive decline; Age-associated memory impairment; Age-related cognitive decline; Aging; Ammon Horn; Assay; Autopsy; Behavioral; Behaviors, Adaptive; Benign senescent forgetfulness; Benzamides; Bioassay; Biologic Assays; Biological Assay; Biological Neural Networks; Biological Preservation; Blotting, Western; Brain; Chromatin; Chromatin Structure; Code; Coding System; Cognition; Cognitive; Cognitive aging; Common Rat Strains; Complement; Complement Proteins; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Coupled; Cytoskeletal Proteins; DNA Sequence Rearrangement; Development; Dorsal; Dose; Drugs; Electromagnetic, Laser; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Exhibits; FDG PET; Foundations; Funding; Gene Transcription; Genes; Genetic Transcription; Genetics, in situ Hybridization; Goals; HDAC; HDAC Agent; HDAC Proteins; Hippocampal Formation; Hippocampus; Hippocampus (Brain); Histone Acetylase; Histone Acetylation; Histone Deacetylase; Histone Deacetylase Inhibitor; Histone deacetylase inhibition; Histones; History; Human, Adult; Hydrogen Oxide; Image; Impairment; In Situ Hybridization; Individual Differences; Intervention; Intervention Strategies; Intervention Trial; Investigation; Lasers; Learning; Link; MR Imaging; MR Tomography; MRI; MS-275; Macaca mulatta; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rats; Maps; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Medication; Memory; Memory Deficit; Memory impairment; Messenger RNA; Metabolic; Microscopic; Modeling; Monkeys; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMR Imaging; NMR Tomography; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocognitive; Neurocyte; Neurons; Nuclear; Nuclear Magnetic Resonance Imaging; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Play; Population Study; Positron Emission Tomography Scan; Positron-Emission Tomography; Prefrontal Cortex; Preservation, Biologic; Preservation, Biological; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Progress Reports; Proton Magnetic Resonance Spectroscopic Imaging; Pyramidal Cells; RNA Expression; RNA, Messenger; Rad.-PET; Radiation, Laser; Rat; Rattus; Reading; Rearrangement; Receptors, N-Methylaspartate; Recording of previous events; Regulation; Relative; Relative (related person); Reports, Progress; Research; Research Resources; Resources; Rest; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Scanning; Senescence; Sodium Butyrate; Specificity; Striate Body; Striatum; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Training; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Validation; Water; Western Blotting; Western Blottings; Western Immunoblotting; Zeugmatography; adaptation behavior; adaptive behavior; adult human (21+); adult youth; age dependent; age effect; age related; aged; aging effect; aging hippocampus; base; butyric acid, sodium salt; cellular development; chromatin remodeling; cognitive control; drug/agent; effective intervention; effective therapy; experience; experiment; experimental research; experimental study; flexibility; fluorodeoxyglucose PET; fluorodeoxyglucose positron emission tomography; frontal cortex; frontal lobe; functional status; hippocampal; hippocampal subregions; histone acetyltransferase; histone modification; imaging; improved; in situ Hybridization Staining Method; in vivo; intervention development; intervention therapy; interventional strategy; long term memory; mRNA; mRNA Expression; necropsy; neural network; neurobiological; neuronal; non-human primate; nonhuman primate; novel; postmortem; preservation; programs; protein blotting; protein expression; research study; response; senescence; senescent; social role; sodium butanoate; striatal; therapy development; trafficking; treatment development; treatment effect; valproate; young adult",NEUROANTOMY OF THE AGED HIPPOCAMPAL FORMATION,,9973,ZAG1,Special Emphasis Panel,,18,,315475
8018581,P01,AG,5,,,,,5P01AG009973-18,9003,,2010,NATIONAL INSTITUTE ON AGING,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GALLAGHER, MICHELA ;",1882110;,5P01AG009973,,,"Aging; Ammon Horn; Animals; Archives; Bio-Informatics; Bioinformatics; Cognition; Cognitive; Communication; Communities; Consultations; Cornu Ammonis; Data; Ensure; Evaluation Research; Event; Future; Hippocampus; Hippocampus (Brain); Individual; Investigators; Organization Charts; Play; Procedures; Process; Productivity; Programs (PT); Programs [Publication Type]; Progress Reports; Publications; R01 Mechanism; R01 Program; RPG; Records; Reports, Progress; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research, Evaluation; Researchers; Resource Sharing; Resources; Role; Sampling; Scientific Publication; Senescence; Shipping; Ships; System; System, LOINC Axis 4; Update; Work; animal resource; animal tissue; blind; data management; experience; experiment; experimental research; experimental study; hippocampal; meetings; organizational structure; programs; research study; senescent; sharing data; social role",ADMINISTRATIVE CORE,,9973,ZAG1,Special Emphasis Panel,,18,,105179
8018582,P01,AG,5,,,,,5P01AG009973-18,9004,,2010,NATIONAL INSTITUTE ON AGING,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GALLAGHER, MICHELA ;",1882110;,5P01AG009973,,,"Aging; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Archives; Banking, Tissue; Behavior assessment; Behavioral; Blood Sample; Blood specimen; Body Tissues; Brain; Brain region; Cells; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Cornu Ammonis; Cues; DISSEC; Data; Data Files; Dissection; Disturbance in cognition; Encephalon; Encephalons; Equipment and supply inventories; Files, Data; Fresh Tissue; Funding; Funding Mechanisms; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Goals; Health; Hippocampus; Hippocampus (Brain); Human; Human Resources; Human, General; Hydrogen Oxide; Impaired cognition; Impairment; In Vitro; Individual; Individual Differences; Inventory; Investigators; Learning; Life; Long-Evans Rats; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manpower; Methods; Modeling; Monkeys; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocognitive; Neurocyte; Neurons; Organ; Perfusion; Peripheral; Physiologic; Physiological; Position; Positioning Attribute; Procedures; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Rat; Rats, Long-Evans; Rattus; Records; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Specimen; Researchers; Resource Sharing; Resources; Rodent; Rodentia; Rodentias; Scientist; Senescence; Severities; Shipping; Ships; Specific qualifier value; Specified; Specimen; Study Subject; System; System, LOINC Axis 4; Testing; Tissue Banking; Tissue Banks; Tissue Collection; Tissue, Fresh; Tissue/Specimen Collection; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; Videotape; Water; Work; aged; animal resource; base; behavior test; behavioral assessment; behavioral test; cognitive change; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cohort; disability; health record; hippocampal; in vivo; male; mid life; mid-life; middle age; middle aged; midlife; model organism; neurobiological; neuronal; non-human primate; nonhuman primate; pathogen; personnel; programs; senescent",ANIMAL RESOURCE,,9973,ZAG1,Special Emphasis Panel,,18,,420990
8018583,P01,AG,5,,,,,5P01AG009973-18,9005,,2010,NATIONAL INSTITUTE ON AGING,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"COLANTUONI, CARLO ;",2059790;,5P01AG009973,,,"Aging; Ammon Horn; Archives; Area; Back; Behavioral; Bio-Informatics; Bioinformatics; Cognition; Common Rat Strains; Complex; Computer Programs; Computer software; Computers; Consultations; Core Facility; Cornu Ammonis; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dorsum; Gene Expression; Genes; Hippocampus; Hippocampus (Brain); History; Human Resources; Individual; Investigation; Investigators; Macaca mulatta; Mammals, Rats; Manpower; Method LOINC Axis 6; Methodology; Microarray Analysis; Microarray-Based Analysis; Neurobiology; Neurocognitive; North Carolina; On-Line Systems; Online Systems; Play; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Publications; Rat; Rattus; Recording of previous events; Records; Research; Research Personnel; Research Resources; Researchers; Resource Development; Resources; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Schools, Medical; Science of Statistics; Scientific Publication; Secure; Senescence; Software; Specialist; Statistics; System; System, LOINC Axis 4; Testing; Uncertainty; Universities; Update; Work; aged; analytical method; animal resource; base; clinical data repository; clinical data warehouse; computer program/software; computerized data processing; data management; data processing; data repository; design; designing; doubt; experience; experiment; experimental research; experimental study; genome-wide; hippocampal; interest; medical schools; member; microarray technology; neurobiological; online computer; personnel; programs; relational database; repository; research study; senescent; signal processing; social role; statistics; task analysis; tool; web based",BIOINFORMATICS/DATA MANAGEMENT,,9973,ZAG1,Special Emphasis Panel,,18,,230990
7784566,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,,NCI:4743330;,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"HANNON, GREGORY J;",1928172;,5P01CA013106,02/10/1997,12/31/2011,,Cold Spring Harbor Laboratory Cancer Research Center,,13106,ZCA1,Special Emphasis Panel,,39,4743330,
8018463,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,0007,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"KRAINER, ADRIAN R;",1863448;,5P01CA013106,,,"5' Splice Site; A-B Family hnRNP Proteins; Accounting; Alternate Splicing; Alternative Splicing; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Bladder; Breast Carcinoma; Bypass; Cancer Genes; Cancer Susceptibility Gene; Cancer Treatment; Cancer of Breast; Cancer-Predisposing Gene; Cancer-Promoting Gene; Cancers; Carcinoma of the Liver Cells; Cell Culture Techniques; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cells; Cellular Oncogene; Cellular Regulation; Center for Cancer Research; Classification; Colon or Rectum; Colorectal; Consensus; Development; Donor Sites, Splice; Early Diagnosis; Emerogenes; Epithelial Cells; Family; Fibroblasts; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic defect; Genome Instability; Genomic Instability; HCC; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Human; Human, General; Individual; Inherited Predisposition; Inherited Susceptibility; Isoforms; Laboratories; Lesion; Link; Lung; Lymphomagenesis; Maintenance; Maintenances; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Modeling; Modification; Molecular; Mutation; NCI Center for Cancer Research; Oncogene Products; Oncogene Proteins; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Oncoproteins; Pathway interactions; Position; Positioning Attribute; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Pre-mRNA; Predisposition; Prevalence; Primary carcinoma of the liver cells; Process; Protein Isoforms; Proteins; Proteomics; Proto-Oncogenes; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger; RNA, Messenger, Precursors; RNA-Binding Proteins; Regulation; Respiratory System, Lung; Role; Signal Pathway; Specificity; Splicing; Structure; Susceptibility; Systematics; Transcript; Transforming Genes; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor-Derived; Tumorigenicity; Type A-B hnRNP Proteins; U1 RNA; U1 small nuclear RNA; U1 snRNA; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Bladder; anticancer therapy; base; c-ONC; cancer therapy; cell growth regulation; cell transformation; early detection; flexibility; gene product; genetic etiology; genetic manipulation; genetic mechanism of disease; genetic vulnerability; genome mutation; hnRNP A-B Proteins; hnRNP A1; improved; loss of function; mRNA; mRNA Precursor; malignancy; malignant breast neoplasm; member; mouse model; neoplasm/cancer; novel; oncosuppressor gene; overexpression; pathway; premRNA; protooncogene; pulmonary; social role; transformed cells; tumor; tumorigenesis; urinary bladder",Regulation of Pre-mRNA Splicing in Tumorigenesis,,13106,ZCA1,Special Emphasis Panel,,39,,630042
8018464,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,0025,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"STILLMAN, BRUCE W;",1888037;,5P01CA013106,,,"APF-1; ATP-Dependent Proteolysis Factor 1; Address; Adenoviridae; Adenoviruses; Affect; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biology; Blood Precursor Cell; Burkitt Herpesvirus; Burkitt Lymphoma Virus; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Function; Cell Process; Cell Signaling; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Center for Cancer Research; Centrioles; Centromere; Centrosome; Chromatin Assembly; Chromatin Modeling; Chromosome Segregation; Chromosomes; Collaborations; Complex; Cytokinesis; Cytoplasmic Division; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA Tumor Viruses; DNA biosynthesis; DNA replication origin; E-B Virus; EB virus; EBV; Epstein Barr Virus; Epstein-Barr Virus; Eukaryote; Eukaryotic Cell; Event; Funding; Genes; Genetic; Genetic Screening; Genome; Genomics; Goals; Grant; HHV-4; HMG-20; Hematopoietic stem cells; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Heterochromatin; High Mobility Protein 20; Human; Human Herpesvirus 4; Human, General; Infectious Mononucleosis Virus; Inheritance Patterns; Interphase Cell; Intracellular Communication and Signaling; Kinetochores; Laboratories; Learning; Libraries; Ligand Binding Protein; Link; M Phase; M phase (cell cycle); MTOC; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods; Mice; Microtubule-Organizing Center; Mitosis; Mitosis Stage; Modification; Molecular Interaction; Murine; Mus; NCI Center for Cancer Research; NIGMS; National Institute of General Medical Sciences; Nature; Non-dividing Cell; Normal Cell; ORC protein; Phase; Plasmids; Polyomavirus macacae; Polyomavirus maccacae 1; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pre-Replication Complex; Process; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulatory Pathway; Replication Initiation; Research; Research Support; Resting Cell; Role; SV 40; SV 40 Virus; SV40; SV40 Virus; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Simian Vacuolating Virus 40; Simian virus 40; Source; Staging; Subcellular Process; Time; Tumor Cell; Ubiquitin; Vacuolating Agent; Virus; Virus Replication; Viruses, General; Yeasts; anticancer research; base; biological signal transduction; cancer cell; cancer research; chromatin assembly factor 1; chromatin assembly factor I; chromosome replication; eukaryotida; gene product; human herpesvirus 4 group; in vivo; interest; malignancy; neoplasm/cancer; neoplastic cell; novel; origin recognition complex; pre-RC; programs; reconstitute; reconstitution; social role; vacuolating virus; virus multiplication",Chromosome Inheritance,,13106,ZCA1,Special Emphasis Panel,,39,,734537
8018465,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,0026,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"TANSEY, WILLIAM PATRICK;",7856040;,5P01CA013106,,,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Adenoviridae; Adenoviruses; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Boxing; Cancer of Breast; Cancers; Carcinoma of the Liver Cells; Cell Death, Programmed; Cells; Center for Cancer Research; Cessation of life; Death; Elements; Funding; Gene Transcription; Generalized Growth; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Growth; HCC; HMG-20; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; High Mobility Protein 20; Human; Human, General; In element; Indium; Laboratories; Learning; Lymphomagenesis; Macropain; Macroxyproteinase; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Model System; Models, Biologic; Molecular; Multicatalytic Proteinase; Mutation; NCI Center for Cancer Research; Normal Cell; Oncogene Products; Oncogene Proteins; Oncogenesis; Oncogenic; Oncoproteins; Pathway interactions; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary carcinoma of the liver cells; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteins; Proteomics; Proteosome; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Role; Sequence-Specific Posttranscriptional Gene Silencing; System; System, LOINC Axis 4; Tissue Growth; Transcription; Transcription, Genetic; Tumor-Derived; Ubiquitin; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; United States; Viral; Work; base; cancer cell; experiment; experimental research; experimental study; gene product; genome mutation; insight; malignancy; malignant breast neoplasm; mouse model; multicatalytic endopeptidase complex; mutant; neoplasm/cancer; ontogeny; pathway; research study; social role; transcription factor; tumor; tumorigenesis",Proteolytic Control of Oncoprotein Function,,13106,ZCA1,Special Emphasis Panel,,39,,604307
8018466,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,0027,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"HANNON, GREGORY J;",1928172;,5P01CA013106,,,"21+ years old; Adult; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Assay; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Bio-Informatics; Bioassay; Biogenesis; Bioinformatics; Biologic Assays; Biological Assay; Biological Function; Biological Process; Body Tissues; Breast Carcinoma; Cancer Genes; Cancer-Promoting Gene; Cancers; Carcinoma of the Liver Cells; Cell Culture Techniques; Cell Death, Programmed; Cell Growth and Maintenance; Cell Maintenance; Cell Transformation, Neoplastic; Center for Cancer Research; Chromosome 13; Chromosomes, Human, Pair 13; Code; Coding System; Complement; Complement Proteins; DICER1; DICER1 Protein; DICER1 protein, human; DNA Alteration; DNA mutation; Data; Dcr-1 Homolog; Development; Dicer; Dicer1, Dcr-1 homolog (Drosophila) protein, human; EC 3.1.26.-; ES cell; Embryo Development; Embryogenesis; Embryonic Development; Emerogenes; Endoribonuclease Dicer; Expression Profiling; Expression Signature; Functional RNA; Funding; Gene Action Regulation; Gene Alteration; Gene Expression Regulation; Gene Mutation; Gene Organization; Gene Regulation; Gene Regulation Process; Gene Structure; Gene Structure/Organization; Generations; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetics, in situ Hybridization; Genome; Goals; HCC; HERNA; HERNA protein, human; Helicase with RNase Motif; Helicase-MOI; Hematologic Body System; Hematopoietic Body System; Hematopoietic System; Hepatic Lymphoma; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Homolog of Drosophila Dicer; Human; Human, Adult; Human, General; In Situ Hybridization; K12H4.8-Like; KIAA0928; Laboratories; Lesion; Liver; Lymphoma of the Liver; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Carcinoma; Mammary Glands, Human; Mammary Tumorigenesis; Mammary gland; Man (Taxonomy); Man, Modern; Messenger RNA; Methods; Mice; Micro RNA; MicroRNAs; Modeling; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Murine; Mus; Mutation; NCI Center for Cancer Research; Neoplastic Cell Transformation; Non-Coding; Non-Coding RNA; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Organ System, Hematologic; Origin of Life; Pathway interactions; Pattern; Phenotype; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary carcinoma of the liver cells; Progenitor Cells; Proteins; Proteomics; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Role; Sequence Alteration; Sequence-Specific Posttranscriptional Gene Silencing; Small RNA; Stem cells; Structure; Testing; Tissues; Transforming Genes; Tumor Suppressing Genes; Tumor Suppressor Genes; adult human (21+); body system, hepatic; cell type; embryonic stem cell; gain of function; gene product; genetic manipulation; genome mutation; human DICER1 protein; in situ Hybridization Staining Method; loss of function; mRNA; mRNA Expression; malignancy; mammary; miRNA; molecuar profile; molecular signature; mouse model; mutant; neoplasm/cancer; neoplastic transformation; oncosuppressor gene; organ system, hepatic; pathway; progenitor; protein expression; social role; stem; stem cell of embryonic origin; tumor; tumor initiation; tumorigenesis",microRNAs in Human Cancer,,13106,ZCA1,Special Emphasis Panel,,39,,684342
8018467,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,0028,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"LOWE, SCOTT W;",1932336;,5P01CA013106,,,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adenovirus E1A Proteins; Anti-Cancer Agents; Anti-Oncogenes; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogenes; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Apoptotic; Bypass; Cancer Drug; Cancer Genes; Cancer-Promoting Gene; Cancers; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Center for Cancer Research; Chemotherapeutic Agents, Neoplastic Disease; Coupled; Coupling; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E1A Protein; EC 2.7; Emerogenes; Epithelial; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Germinoblastoma; Growth; HCC; Hand; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Intracellular Communication and Signaling; Kinases; Laboratories; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mutation; NCI Center for Cancer Research; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P53; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary carcinoma of the liver cells; Process; Programs (PT); Programs [Publication Type]; PtdIns 3-Kinase; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; TP53; TP53 gene; TRP53; Technology; Therapeutic; Tissue Growth; Transforming Genes; Transphosphorylases; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tumor-Specific Treatment Agents; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Work; anticancer agent; anticancer drug; biological signal transduction; comparative; gene function; genome mutation; in vivo; insight; interest; malignancy; mouse model; necrocytosis; neoplasm/cancer; neoplastic cell; oncosuppressor gene; ontogeny; pathway; programs; rapid method; rapid technique; response; social role; tool; tumor; tumor suppressor; tumorigenesis",Tumor Suppression,,13106,ZCA1,Special Emphasis Panel,,39,,753240
8018468,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,9004,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"HANNON, GREGORY J;",1928172;,5P01CA013106,,,"Animals; Archives; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Cataloging; Catalogs; Cells; Center for Cancer Research; Communities; Cultured Cells; Custom; Development; Gene Expression; Gene Inactivation; Gene Products, RNA; Gene Silencing; Genes; Genetic; Goals; Grant; Individual; Laboratories; Libraries; Method LOINC Axis 6; Methodology; Methods; Modification; NCI Center for Cancer Research; Plasmids; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Production; Programs (PT); Programs [Publication Type]; Quality Control; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; RNAi vector; Reagent; Recombinants; Research Resources; Resources; Retroviridae; Retroviruses; Ribonucleic Acid; Role; Sequence-Specific Posttranscriptional Gene Silencing; Services; System; System, LOINC Axis 4; Testing; Time; Virus-Retrovirus; Work; base; design; designing; gene function; genome-wide; inhibitor; inhibitor/antagonist; interest; member; programs; shRNA; short hairpin RNA; small hairpin RNA; social role; tissue culture; tool; vector",Modulation of Gene Expression Through RNAi,,13106,ZCA1,Special Emphasis Panel,,39,,473249
8018469,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,9005,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"LOWE, SCOTT W;",1932336;,5P01CA013106,,,"Animal Model; Animal Models and Related Studies; Animals; Breast Carcinoma; Cancer Biology; Cancer Genes; Cancer-Promoting Gene; Carcinoma of the Liver Cells; Cell Death; Cells; Center for Cancer Research; Data; Data Quality; Ensure; Funding; Generations; Germinoblastoma; Goals; Grant; HCC; Hematopoietic; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Histology; Histopathology; Individual; Investigators; Laboratories; Liver; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Mammals, Mice; Mammary Carcinoma; Mammary Glands, Human; Mammary gland; Methods and Techniques; Methods, Other; Mice; Modeling; Monitor; Mother Cells; Mouse Models of Human Cancer; Mouse Strains; Murine; Mus; NCI Center for Cancer Research; Oncogenes; Oncogenesis; Oncogenic; Pathologist; Phenotype; Primary carcinoma of the liver cells; Probability; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Quality Control; Quality, Data; Research Personnel; Researchers; Reticulolymphosarcoma; Sarcoma, Germinoblastic; Series; Services; Source; Stem cells; System; System, LOINC Axis 4; Techniques; Time; Training; Transforming Genes; Tumor Biology; Tumor-Derived; animal colony; body system, hepatic; cost; cost effective; experience; experiment; experimental research; experimental study; genetic manipulation; human cancer mouse model; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; mammary; member; model organism; mouse model; mutant; necrocytosis; organ system, hepatic; programs; research study; success; training project; tumorigenesis",Mosaic Mouse Models of Human Cancer,,13106,ZCA1,Special Emphasis Panel,,39,,430396
8018470,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA013106-39,9006,,2010,NATIONAL CANCER INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"POWERS, SCOTT ;",1943942;,5P01CA013106,,,"Address; Administrator; Alternate Splicing; Alternative Splicing; Area; Arts; Bio-Informatics; Bioinformatics; Biological; Biostatistics Core; Cell Extracts; Center for Cancer Research; Computers; Core Facility; DNA copy number; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Expression Profiling; Expression Signature; GWAS; Gene Copy Number; Gene Dosage; Gene Expression; Genes; Genome; Genomics; Human; Human, General; Iceland; Individual; Informatics; Isoforms; Laboratories; Macromolecular Protein Complexes; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mice; Micro RNA; MicroRNAs; Molecular Fingerprinting; Molecular Profiling; Multiprotein Complexes; Murine; Mus; NCI Center for Cancer Research; Photometry/Spectrum Analysis, Mass; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Protein Isoforms; Proteins; Proteomics; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA Splicing; RNA Splicing, Alternative; RNAi; Resolution; Role; Scientist; Sequence-Specific Posttranscriptional Gene Silencing; Services; Slide; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Technology; Work; base; clinical data repository; clinical data warehouse; data repository; flexibility; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; innovate; innovation; innovative; member; miRNA; molecuar profile; molecular signature; programs; protein complex; relational database; social role; tool; whole genome association studies; whole genome association study",Genomics and Proteomic Analysis,,13106,ZCA1,Special Emphasis Panel,,39,,433217
7796738,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,,NCI:1804658;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,NONE,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"TANNENBAUM, STEVEN R;",1871395;,5P01CA026731,01/15/1997,12/31/2013,,Endogenous Nitrite Carcinogenesis in Man,,26731,ZCA1,Special Emphasis Panel,,31,1804658,
8017417,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7983,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"DEEN, WILLIAM M;",6499464;,5P01CA026731,,,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; Address; Antioxidants; Biological; Body Tissues; Cancer Induction; Cancers; Cell Culture Techniques; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chronic; Colon; Computer Simulation; Computer Systems Development; Computerized Models; Consumption; Development; Development, Computer Systems; Diffusion; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Experimental Models; Experimental Models, Other; Exposure to; Gases; Genetic Alteration; Genetic Change; Genetic defect; Genome; INFLM; Immune system; In Vitro; Inflammation; Kinetic; Kinetics; Lipids; Macropain; Macroxyproteinase; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Microfluidic; Microfluidics; Modeling; Models, Computer; Models, Experimental; Mononitrogen Monoxide; Multicatalytic Proteinase; Mutation; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Compounds, Unspecified; Nitrogen Dioxide; Nitrogen Monoxide; Nitrogen Oxides; Nitrogen Peroxide; Nitrogen Protoxide; Nitrogen oxide; Nitrogen oxide (NO2); Pathway interactions; Peroxonitrite; Peroxonitrites; Peroxynitrites; Physiologic; Physiological; Production; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteosome; Reaction; Reactive Nitrogen Species; Simulation, Computer based; Solutions; System; System, LOINC Axis 4; Systems Development; Technology; Testing; Tissue Model; Tissues; Toxic effect; Toxicities; anti-oxidant; base; biological systems; biomarker; body system, allergic/immunologic; carcinogenesis; chemical reaction; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cultured cell line; dinitrogen trioxide; endothelial cell derived relaxing factor; genome mutation; improved; in silico; in vitro testing; interest; malignancy; man; man's; melanoma; multicatalytic endopeptidase complex; neoplasm/cancer; new approaches; nitrogen compound; nitrogen compounds; nitrogen trioxide; nitrous anhydride; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; oxidation; pathway; peroxynitrite; virtual simulation",Reaction and Diffusion of Nitric Oxide in Biological Systems,,26731,ZCA1,Special Emphasis Panel,,31,,146678
8017418,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7984,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"DEDON, PETER C;",1890419;,5P01CA026731,,,"2-Amino-6-Hydroxypurine; 3-mononitrotyrosine; 3-nitrotyrosine; 6H-Purin-6-one, 2-amino-1,7-dihydro-; Animal Model; Animal Models and Related Studies; Archives; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; Cancer Induction; Cancerous; Cancers; Carbohydrates; Causality; Cell Death; Cell model; Cells; Cellular model; Chemical Models; Chemicals; Chemistry; Chemoprevention; Citrobacter; Clinical; Co-culture; Cocultivation; Coculture; Coculture Techniques; Colitis; Colon; Crohn's disease; Crohn's disorder; Cultured Cells; DNA; DNA lesion; Deoxyribonucleic Acid; Development; Doctor of Medicine; Enteritis, Granulomatous; Epithelial Cells; Etiology; Gene Products, RNA; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; Group 17 Elements; Guanine; HL-60; HL60; Halogens; Heterophil Granulocyte; History; Human; Human, General; INFLM; Immune; Inflammation; Inflammation Mediators; L-Tyrosine; Laboratories; Lead; Lesion; Link; Lipid Peroxidation; Lipids; M.D.; Malignant; Malignant - descriptor; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Markers, Surrogate; Marrow Neutrophil; Measurement; Melanoma Cell; Methods; Modeling; Models, Chemical; Mutation; N element; N2 element; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nitrites; Nitrogen; Nucleic Acids; Paraffin; Paraffin waxes and Hydrocarbon waxes; Patients; Pb element; Phagocytes; Phagocytic Cell; Physiology; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proteins; RNA; RNA marker; RNA, Non-Polyadenylated; Reaction; Recording of previous events; Reproduction spores; Resistance; Ribonucleic Acid; Sampling; Science of Chemistry; Site; Spores; Surrogate Markers; System; System, LOINC Axis 4; TYR; Tissues; Translating; Translatings; Tyrosine; Tyrosine, L-isomer; Ulcerated Colitis; Ulcerative Colitis; Work; amebocyte; analytical method; biomarker; carcinogenesis; chemical reaction; computer based prediction; cytokine; disease causation; disease etiology; disease/disorder etiology; disorder etiology; eleocolitis; gene product; genome mutation; granulomatous enterocolitis; heavy metal Pb; heavy metal lead; human disease; human tissue; language translation; macrophage; malignancy; man; man's; melanoma; model organism; mouse model; necrocytosis; neoplasm/cancer; neutrophil; nitrotyrosine; oxidation; para-Tyrosine; predictive modeling; programs; reconstitute; reconstitution; regional enteritis; resistant; tumor","DNA and protein reactions of NO', ONOO-, and reactive species produced by phagocy",,26731,ZCA1,Special Emphasis Panel,,31,,366071
8017419,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7985,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"WOGAN, GERALD N;",1897888;,5P01CA026731,,,"2-Amino-6-Hydroxypurine; 2-chloroacetaldehyde; 6H-Purin-6-one, 2-amino-1,7-dihydro-; Active Oxygen; Address; Adenocarcinoma Cell; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Biochemical; Biological; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Boxing; Bypass; CSIF; CSIF-10; Cancer Induction; Cancers; Carcinogen-DNA Adducts; Carcinoma Cell; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cells; Chemicals; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinical; Closure by Ligation; Collaborations; Collection; Colon Adenocarcinoma; Colon Cancer; Colon Carcinoma; Colonic Adenocarcinoma; Colonic Carcinoma; Coupled; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); DNA Adducts; DNA Damage; DNA Injury; DNA lesion; Data; Development; Dose; Dose-Rate; E coli; Enzymes; Escherichia coli; Experimental Models; Experimental Models, Other; Exposure to; Fingerprint; Frequencies (time pattern); Frequency; Future; Genes; Genes, Reporter; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Goals; Guanine; HCT 116 Cells; HCT116; HCT116 Cells; HL-60 Cells; HL60 Cells; HPLC; Heterophil Granulocyte; High Pressure Liquid Chromatography; Human; Human, General; ICE-like protease; IL-10; IL10; IL10A; INFLM; Immune; In Vitro; Induction of Apoptosis; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interleukin 10 Precursor; Interleukin-10; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; Lesion; Ligation; Link; Lipids; Lymphocytes, Null; METBL; Malignant; Malignant - descriptor; Malignant Epithelial Cell; Malignant Glandular Cell; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Melanoma Cell; Membrane; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Mice; Mice, Transgenic; Modeling; Models, Experimental; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Mutation; Mutation Spectra; N element; N2 element; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nitrites; Nitrogen; Nitrosation; Null Cells; Null Lymphocytes; O element; O2 element; Oligo; Oligonucleotides; Organism; Outcome; Oxygen; Oxygen Radicals; P53; Pathway interactions; Patients; Pigments; Plasmids; Polymerase; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Pro-Oxidants; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Reactive Nitrogen Species; Reactive Oxygen Species; Regulation; Reporter Genes; Resistance; Risk; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Staging; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Testing; Toxic effect; Toxicities; Transgenic Mice; Translations; Tumor Cell; Tumor Protein p53 Gene; Viral Genome; Virus; Viruses, General; adduct; base; biological signal transduction; biomarker; cancer risk; carcinogenesis; caspase; chloroacetaldehyde; cystein protease; cystein proteinase; cysteine endopeptidase; design; designing; experiment; experimental research; experimental study; gene product; genome mutation; genotoxicity; in vivo; inhibitor; inhibitor/antagonist; insight; living system; macromolecule; macrophage; malignancy; man; man's; melanoma; membrane structure; mutant; necrocytosis; neoplasm/cancer; neoplastic cell; neutrophil; novel; pathway; prevent; preventing; programs; repair; repaired; research study; resistant; response; social role; tool","Characterization of Mutagenesis, Mutational Spectra and Mechanisms of Toxicity",,26731,ZCA1,Special Emphasis Panel,,31,,367263
8017420,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7986,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"SCHAUER, DAVID B;",1876599;,5P01CA026731,,,"Adoptive Transfer; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; C57BL/6 Mouse; CSIF; CSIF-10; Cancer Induction; Cancers; Cells; Chemicals; Citrobacter freundii Biotype 4280; Citrobacter rodentium; Colitis; Colon; Computer Simulation; Computerized Models; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); DNA Damage Repair; DNA Recombination; DNA Repair; DNA recombination (naturally occurring); Direct Repeats; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enzymes; Epithelial Cells; Eragrostis; Event; Genes; Genetic Recombination; Genetics-Mutagenesis; Helicobacter; Helicobacter hepaticus; Hepatocyte Nitric Oxide Synthase; Heterophil Granulocyte; IL-10; IL10; IL10A; INFLM; INOS; Inducible Nitric Oxide Synthase; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interleukin 10 Precursor; Interleukin-10; Large Intestine; Lesion; Macrophage Nitric Oxide Synthase; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Neutrophil; Mathematical Model Simulation; Mathematical Models and Simulations; Mice; Mice, Mutant Strains; Model System; Modeling; Models, Biologic; Models, Computer; Molecular Biology, Mutagenesis; Mononitrogen Monoxide; Mucosal Inflammation; Mucositis; Murine; Mus; Mutagenesis; Mutant Strains Mice; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nitric Oxide; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Oxidative Stress; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Programs (PT); Programs [Publication Type]; Recombination; Recombination, Genetic; Repeats, Direct; Reporter; Research Specimen; Role; Series; Simulation, Computer based; Somatic Mutation; Specimen; T-Cells; T-Lymphocyte; Teff; Thymus-Dependent Lymphocytes; Transgenes; Translating; Translatings; Unscheduled DNA Synthesis; base; biomarker; cancer risk; carcinogenesis; colitis associated cancer; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; homologous recombination; human NOS2A protein; iNOS enzyme; in silico; in vivo; language translation; large bowel; macrophage; malignancy; man; man's; mouse model; mouse mutant; neoplasm/cancer; neutrophil; nitric oxide synthase, Type II; novel; prevent; preventing; programs; research study; social role; thymus derived lymphocyte; virtual simulation",In Vivo Role of Nitric Oxide in Muscosal Inflammation and Cancer,,26731,ZCA1,Special Emphasis Panel,,31,,316790
8017421,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7987,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"WISHNOK, JOHN S.;",2453047;,5P01CA026731,,,"2,3-Butanediol, 1,4-dimercapto-, (R*,R*)-; 2-Deoxyribose; 3-mononitrotyrosine; 3-nitrotyrosine; API; Absolute ethanol; Albumins; Alcohol, Ethyl; Ammonium; Analysis, Data; Animal Model; Animal Models and Related Studies; Antibodies; Area; Arts; Atmospheric Pressure; Behavior; Biochemistry; Biological; Biological Models; Body Tissues; Buffers; Cancer Induction; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; Cell/Tissue, Immunohistochemistry; CellLine; Chemicals; Chemistry, Biological; Chromatography; Chromatography / Separation Science; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Cleland's Reagent; Clinical; Cluster Analyses; Cluster Analysis; Collaborations; Collection; Complex Mixtures; Computer Programs; Computer software; Crossmatching, Tissue; D-erythro-Pentose, 2-deoxy-; DNA; Data; Data Analyses; Deoxyribonucleic Acid; Deoxyribose; Detection; Development; Digestion; Disease; Disorder; Dithiothreitol; ETOH; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Ethanol; Evaluation; Exposure to; Expression Profiling; Expression Signature; Fixation; Formaldehyde; Formalin; Formic Aldehyde; Freezing; Funding; Gene Expression; Goals; Grain Alcohol; HPLC; Hand; Heating; High Pressure Liquid Chromatography; Histocompatibility Testing; Human; Human Resources; Human, General; Hydrogen Oxide; Hydrolysis; IHC; INFLM; Ice; Imagery; Immersion; Immersion Investigative Technique; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Incubated; Individual; Inflammation; Intracellular Communication and Signaling; Investigators; Ions; K element; L-Tyrosine; LC/MS; Laboratories; Lead; Licensing; Liquid substance; MAPI; Man (Taxonomy); Man, Modern; Manpower; Mass Spectrum; Mass Spectrum Analysis; Measures; Methanal; Methods; Methods and Techniques; Methods, Other; Methyl Aldehyde; Methylcarbinol; Microscope; Microtomy; Model System; Models, Biologic; Molecular Fingerprinting; Molecular Profiling; Mononitrogen Monoxide; Na element; Nitrates; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nucleic Acids; Nucleosides; Organic Solvents; Organic solvent product; Outcome; Oxomethane; PNA; Paraffin; Paraffin Embedding; Paraffin waxes and Hydrocarbon waxes; Pathology; Pb element; Peptide Nucleic Acids; Peptides; Peroxonitrite; Peroxonitrites; Peroxynitrites; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Potassium; Preparation; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Proteins; Reaction; Recovery; Relative; Relative (related person); Reliance; Reporting; Research Personnel; Research Resources; Researchers; Resolution; Resources; Running; Sampling; Scanning; Science of Statistics; Sensitivity and Specificity; Series; Serum Albumin; Services; Signal Transduction; Signal Transduction Systems; Signaling; Slide; Sodium; Software; Solutions; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Statistics; Supervision; System; System, LOINC Axis 4; TYR; Techniques; Technology; Thin Sectioning; Thin Sectionings; Time; Tissue Crossmatchings; Tissue Sample; Tissue Typing; Tissues; Training; Tripcellim; Trypsin; Tyrosine; Tyrosine, L-isomer; Visualization; Water; Work; Xylene; adduct; alkaline protease inhibitor; aminoacid sequence of peptide; aminoacid sequence of protein; analytical method; animal tissue; aqueous; base; biological signal transduction; biomarker; bityrosine; carcinogenesis; computer program/software; cultured cell line; d-Numb; denitration; design; designing; develop software; developing computer software; disease/disorder; dityrosine; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; fluid; gene product; heavy metal Pb; heavy metal lead; histocompatibility typing; improved; indexing; insight; instrument; interest; ion source; ionization; liquid; liquid chromatography mass spectrometry; man; man's; mass spectrometer; method development; microbial alkaline proteinase inhibitor; model organism; molecuar profile; molecular signature; multiple reaction monitoring; nitration; nitrotyrosine; numb protein; o,o-dityrosine; oxidation; oxidative damage; para-Tyrosine; peptide sequence; peroxynitrite; personnel; programs; protein aminoacid sequence; protein expression; research study; sample fixation; software development; spiroiminodihydantoin; statistics; success; tissue fixing; urinary","Core:  Analytical, Cell Culture, Nitric Oxide Delivery",,26731,ZCA1,Special Emphasis Panel,,31,,295566
8017422,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7988,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"FOX, JAMES G;",1881890;,5P01CA026731,,,"Animal Husbandry; Animals; Cancer Induction; Caring; Cell/Tissue, Immunohistochemistry; Chemicals, Hazardous; Comparative Pathology; Containment; Controlled Environment; ES cell; Embryo Transfer; Ensure; Environment, Controlled; Equipment; Gene Inactivation; Gene Silencing; Germ-Free; Hazardous Chemicals; Histology; Histopathology; Housing; Human Resources; Husbandries, Animal; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Institutes; Investigators; Laboratories; Manpower; Medicine; Mice, Transgenic; Microinjections; Molecular; Mouse Strains; Nitrites; P01 Mechanism; P01 Program; Pathogen Frees, Specific; Pathogenesis; Pathology; Phenotype; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Research; Research Personnel; Research Program Projects; Researchers; Role; Safety; Science of Medicine; Sequence-Specific Posttranscriptional Gene Silencing; Services; Specific Pathogen Frees; System; System, LOINC Axis 4; Technology; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Work; animal facility; animal resource; animal tissue; artificial environment; carcinogenesis; comparative; containment equipment; embryo transplantation; embryonic stem cell; germ free condition; in vivo; man; man's; molecular pathology; mouse model; personnel; programs; social role; specific pathogen free; square foot; stem cell of embryonic origin; transgenic",Animal Resource and Pathology Core,,26731,ZCA1,Special Emphasis Panel,,31,,210705
8017423,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA026731-31,7989,,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"TANNENBAUM, STEVEN R;",1871395;,5P01CA026731,,,"Accounting; Animals; Archives; Biological; Blotting, Western; Body Tissues; Book Chapters; Books; Cancer Induction; Cells; Chapters, Book; Collaborations; Commit; Data; Data Banks; Data Bases; Data Files; Databank, Electronic; Databanks; Database, Electronic; Databases; Documentation; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Ensure; Expenditure; Files, Data; Funding; Gel; HIPAA; HOSP; Health Insurance Portability and Accountability Act; Health Sciences; Histology; Hospitals; Internet; Investigators; Kennedy Kassebaum Act; Literature; Malignant Melanoma; Mammals, Mice; Manuscripts; Mass Spectrum; Mass Spectrum Analysis; Metals; Methodist Church; Methodists; Methods; Mice; Mononitrogen Monoxide; Montana; Murine; Mus; NCI; NCI Organization; NIH; National Cancer Institute; National Institutes of Health; National Institutes of Health (U.S.); Nitrates; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Oregon; Oxidants; Oxidizing Agents; PL 104-191; PL104-191; Peer Review; Photometry/Spectrum Analysis, Mass; Policies; Process; Programs (PT); Programs [Publication Type]; Proteins; Public Law 104-191; Publications; Publishing; Reporting; Reproduction spores; Research; Research Institute; Research Personnel; Researchers; Sampling; Scanning; Scientific Publication; Scientist; Services; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spores; System; System, LOINC Axis 4; Technical Report; Technical Report (PT); Technical Report [Publication Type]; Tissues; Transmission; United States Health Insurance Portability and Accountability Act; United States National Institutes of Health; Universities; WWW; Western Blotting; Western Blottings; Western Immunoblotting; base; carcinogenesis; clinical data repository; clinical data warehouse; cost; data repository; electron acceptor; electronic data; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; gene product; man; man's; melanoma; member; programs; protein blotting; relational database; repair; repaired; repository; research study; sharing data; tandem mass spectrometry; technical report; transmission process; web; web site; world wide web",Administrative Core,,26731,ZCA1,Special Emphasis Panel,,31,,101585
7760065,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,,NCI:1212440;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,ANATOMY/CELL BIOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"STEIN, GARY S.;",1868858;,5P01CA082834,02/01/2001,01/31/2011,,Nuclear Structure and Gene Expression,,82834,ZCA1,Special Emphasis Panel,,10,1212440,
8017462,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,0004,,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"STEIN, GARY S.;",1868858;,5P01CA082834,,,"AML - Acute Myeloid Leukemia; AML1; AML1-ETO; AML1-ETO fusion protein; AML1-MTG8; AMLCR1; Address; Affect; Affinity Chromatography; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Architecture; Assay; Athymic Nude Mouse; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Blood (Leukemia); Body Tissues; Breast Cancer Cell; CBFA2; CHIP assay; Cancer Control; Cancer Control Science; Cancer Genes; Cancer Staging; Cancer-Promoting Gene; Causality; Cell Communication and Signaling; Cell Culture Techniques; Cell Maturation; Cell Nucleus; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Characteristics; Chimera Protein; Chimeric Proteins; Chromatin; Chromatography, Affinity; Chromosomes; Co-Immunoprecipitations; Collaborations; Complement; Complement Proteins; Complex; Complexes, Macromolecular; Coupled; Data; Defect; Development; Diagnostic; Diagnostic Neoplasm Staging; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Eight-Twenty-One; Engineering / Architecture; Environment; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Etiology; Exhibits; FLR; Factor Analyses; Factor Analysis; Failure (biologic function); Funding; Fusion Protein; Gene Action Regulation; Gene Expression; Gene Expression Process; Gene Expression Profile; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genes, Regulator; Genetic Alteration; Genetic Change; Genetic defect; Genetics, in situ Hybridization; Goals; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Human Breast Cancer Cell; Immunofluorescence Microscopy; In Situ Hybridization; Interphase; Intracellular Communication and Signaling; Investigators; Knock-in; Knock-in Mouse; Leukemia, Myelocytic, Acute; Leukemias, General; Leukemogenesis/Lymphomagenesis; Link; M Phase; M phase (cell cycle); Macromolecular Complexes; Malignant Cell; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Mediating; Metaphase; Mice; Mice, Athymic; Mice, Nude; Micro-tubule; Microscopy; Microscopy, Immunofluorescence; Microtubules; Mitosis; Mitosis Stage; Mitotic; Mitotic Apparatus; Mitotic Metaphase; Mitotic Spindle Apparatus; Modeling; Molecular; Molecular Interaction; Monitor; Morphology; Murine; Mus; Mutation; Myeloblastic Leukemia, Acute; Myelogenous; Myelogenous Leukemia, Acute; Myeloid; Myeloid Cells; Myeloid Disease; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Progenitor Cells; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; Neoplasm Staging; Normal Cell; Nuclear; Nuclear Matrix; Nuclear Scaffold; Nuclear Structure; Nucleus; Nude Mice; Oncogenes; Oncogenic; Organism-Level Process; Organismal Process; PEBP2A2; PEBP2aB; Phenotype; Photometry/Spectrum Analysis, Mass; Physiologic; Physiologic Processes; Physiological; Physiological Processes; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Proteome; Proteomics; RNA, Small Interfering; RUNX1; RUNX1 gene; Regulator Genes; Regulatory Pathway; Regulatory Protein; Research Personnel; Researchers; Role; Scaffolding Protein; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stem Cells, Myeloid; Structure; Targetings, Gene; Testing; Time; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transcriptional Regulatory Elements; Transforming Genes; Transmission; Transplantation; Tumor Staging; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; affinity purification; aminoacid sequence of peptide; aminoacid sequence of protein; base; biological signal transduction; cancer cell; cancer diagnosis; cancer progression; cell growth; cell transformation; chromatin immunoprecipitation; chromatin modification; disease causation; disease etiology; disease/disorder etiology; disorder etiology; failure; gene expression signature; gene product; genetic regulatory protein; genome mutation; in situ Hybridization Staining Method; in vivo; insight; leukemia; leukemogenesis; model organism; mouse model; mutant; myeloproliferative neoplasm; neoplasm progression; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; peptide sequence; programs; protein aminoacid sequence; protein function; regulatory gene; regulatory gene product; response; runt domain factor; runx proteins; siRNA; social role; t(8;21); t(8;21)(q22;q22); trafficking; trans acting element; transcription factor; transcriptome; transformed cells; transmission process; transplant; tumor; tumor progression",SUBNUCLEAR TARGETING AND TRANSCRPTIONAL CONTROL DURING INTERPHASE AND MITOSIS IN,,82834,ZCA1,Special Emphasis Panel,,10,,297329
8017463,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,0005,,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"IMBALZANO, ANTHONY N;",1905668;,5P01CA082834,,,"2-dimensional; ATP phosphohydrolase; ATPase; Acinus organ component; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; BRG-1; BRG-1 Gene; BRG1; BRG1 Gene; BRM/SWI2-Related Gene-1; Basement membrane; Biological Models; Biology; Blood Coagulation Factor III; Body Tissues; Breast; Breast Cancer Cell; Breast Neoplasms; Breast Tissue; Breast Tumors; CD142 Antigens; Cancer of Breast; Cell Communication and Signaling; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell-Extracellular Matrix; CellLine; Cells; Cellular Expansion; Cellular Growth; Cellular Morphology; Chromatin; Coagulation Factor III; Coagulin; Collaborations; Data; Development; Dimensions; ECM; Environment; Enzymes; Epithelial; Epithelial Cells; Event; Extracellular Matrix; Factor III; Family member; Gene Expression; Gene Targeting; Generalized Growth; Genes; Genomics; Glomerular Procoagulant Activity; Growth; Growth and Development; Growth and Development function; Human; Human Breast Cancer Cell; Human, General; Individual; Intracellular Communication and Signaling; Investigators; Malignant; Malignant - descriptor; Malignant Cell; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Model System; Models, Biologic; Molecular; Morphogenesis; Neoplasm Metastasis; Nuclear; Nuclear Structure; Nucleus; Oncogenesis; Oncogenic; Phenotype; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prothrombinase; Research Personnel; Researchers; Role; SMARCA4; SMARCA4 gene; SNF2-Beta; SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 Gene; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; Targetings, Gene; Thromboplastin; Tissue Factor; Tissue Factor Procoagulant; Tissue Growth; Tissue Thromboplastin; Tissues; Tumor Cell; Tumor Cell Migration; Tumor Suppressor Proteins; Urothromboplastin; acinus; biological signal transduction; cancer cell; cancer metastasis; cell growth; cell morphology; cell transformation; chromatin remodeling; cultured cell line; in vivo; malignant breast neoplasm; mammary tumor; neoplastic cell; novel; ontogeny; programs; reconstitute; reconstitution; social role; transformed cells; tumor; tumor suppressor; tumorigenesis; tumorigenic; two-dimensional",REGULATORY MECHANISMS CONTROLLING BREAST TISSUE DEVELOPMENT AND TRANSFORMATION,,82834,ZCA1,Special Emphasis Panel,,10,,265968
8017464,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,0006,,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"DOXSEY, STEPHEN J;",1887108;,5P01CA082834,,,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Address; Adenosine Triphosphatase, Dynein; Affect; Aneuploid; Aneuploidy; Anzatax; Asotax; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Bristaxol; Cancer Cause; Cancer Etiology; Cancer Genes; Cancer-Promoting Gene; Cancers; Carcinoma; Cell Cycle Progression; Cell Function; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Process; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Centrosome; Characteristics; Chromosome Segregation; Chromosomes; Collaborations; Complex; Cytokinesis; Cytoplasm; Cytoplasmic Division; Data; Deacetylase; Defect; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Dysfunction; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Export, Nuclear; FLR; Failure (biologic function); Figs; Figs - dietary; Forecast of outcome; Functional disorder; Funding; Future; Gene Expression; Gene Proteins; Gene Transcription; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Growth; HMG-20; High Mobility Protein 20; Human; Human, General; Invasive Lesion; Laboratories; Ligand Binding Protein; Light; Link; M Phase; M phase (cell cycle); MMP-14 gene product; MMP-X1; MMP14; MMP14 gene product; MMP14 protein, human; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Macropain; Macroxyproteinase; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-14; Mediating; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Micro-tubule; Microscopy; Microtubule Stabilization; Microtubules; Mitosis; Mitosis Stage; Mitotic; Mitotic spindle; Molecular; Molecular Interaction; Motor; Multicatalytic Proteinase; Mutation; Nuclear; Nuclear Export; Nuclear Structure; Nucleosomes; Nucleus; Oncogenes; Oncogenesis; Organelles; Paclitaxel; Paclitaxel (Taxol); Phenotype; Photoradiation; Physiopathology; Praxel; Preparation; Prognosis; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Gene Products; Proteins; Proteosome; RNA Expression; RNA Splice Sites; RNA Splicing; Role; Site; Splicing; Subcellular Process; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Therapeutic; Tissue Growth; Transcription; Transcription, Genetic; Transforming Genes; Tubulin; Tumor Cell; Tumor Suppressor Proteins; Tumor-Derived; Ubiquitin; Work; base; cancer cell; cancer diagnosis; cultured cell line; design; designing; driving force; dynein ATP phosphohydrolase (tubulin translocating); epithelial carcinoma; failure; gene product; genome mutation; human MMP14 protein; inhibitor; inhibitor/antagonist; insight; malignancy; member; multicatalytic endopeptidase complex; neoplasm/cancer; neoplastic cell; novel; ontogeny; outcome forecast; overexpression; pathophysiology; pericentrin; prevent; preventing; programs; restoration; social role; tumor; tumor suppressor; tumorigenesis",CENTROSOME-NUCLEAR LINKS AND CANCER,,82834,ZCA1,Special Emphasis Panel,,10,,241936
8017465,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,0007,,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"LIAN, JANE B;",1871231;,5P01CA082834,,,"2ar peptide; 3-D; 3-Dimensional; AML3 transcription factor; ASV; ASVSRC1; ATF; Accounting; Acinus organ component; Address; Affect; Architecture; Assay; BSP; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Bittner Virus; Blood Vessels; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Breast; Breast Cancer Cell; Breast Carcinoma; Breast Neoplasms; Breast Tumors; CBFA-1 protein; CBFA-1 transcription factor; CBFA1 protein; CBFalpha runt domain transcription factor 1; CBFalpha1 protein; CLG4B; Cancer cell line; Cancer of Breast; Cancers; Carcinoma Cell; Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Signaling; Cell-Extracellular Matrix; CellLine; Cells; Cellular Adhesion; Cellular Expansion; Cellular Growth; Centrosome; Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Co-Immunoprecipitations; Collaborations; Complex; Development; Diagnosis; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7.2-; ECM; EP300; EP300 gene; Engineering / Architecture; Environment; Epithelial Cells; Eta-1 protein; Eta-1-Op protein; Event; Extracellular Matrix; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinases; GELB; GFAC; Gene Expression; Gene Expression Profile; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genes, c-src; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Histone Acetylation; Histones; Human; Human Breast Cancer Cell; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Image; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Immunologic, Luciferase; In Situ; In Vitro; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Integrins; Intracellular Communication and Signaling; Investigators; Lead; Lesion; Link; Luciferases; Lytic Metastatic Lesion; MAP kinase; MAPK; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MMP9; MMP9 gene; MMPs; MMTV; Malignant; Malignant - descriptor; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Cancer Virus; Mammary Carcinoma; Mammary Glands, Human; Mammary Neoplasms; Mammary Tumor Virus, Mouse; Mammary gland; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal; Mesenchymal Differentiation; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mitotic; Modeling; Modification; Molecular; Molecular Interaction; Monitor; Morbidity; Morbidity - disease rate; Mouse Mammary Tumor Virus; Mutation; Neoplasm Metastasis; Non-Malignant; Normal Tissue; Normal tissue morphology; Nuclear; Nuclear Matrix; Nuclear Scaffold; Nuclear Structure; Oncogenic; Osf2 transcription factor; Osteoblasts; Osteolysis; Osteolytic; Osteolytic Lesion; P105-RB; PEBP2alphaA protein; PP110; Pathway interactions; Patients; Pb element; Phenotype; Physiologic; Physiological; Primary Neoplasm; Primary Tumor; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Proteomics; RB1; RNA Expression; RNA, Small Interfering; Rb Gene Product; Rb Protein; Rb1 Gene Product; Regulatory Protein; Reporter; Reporting; Repression; Research; Research Personnel; Researchers; Retinoblastoma Associated Protein; Retinoblastoma Protein; Role; Runx2 protein; SEF1 protein; SL3-3 enhancer factor 1; SRC; SRC gene; SRC1; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Somatomedin C; Staging; Targetings, Gene; Testing; Therapeutic; Tissue Growth; Tissues; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Tumor Burden; Tumor Cell; Tumor Cell Migration; Tumor Load; VEGFs; Vascular Endothelial Growth Factors; Vegf; acinus; activating transcription factor; acute myeloid leukemia 3 protein; base; biological signal transduction; bone; bone sialoprotein; bone sialoprotein 1; bone sialoprotein I; bone sialoprotein II; c src; c-src Proto-Oncogenes; cancer cell; cancer metastasis; cancer progression; cell growth; chromatin remodeling; cohort; cultured cell line; cytokine; disease/disorder; early T-lympocyte activation-1 protein; gene expression signature; gene product; genetic regulatory protein; genome mutation; heavy metal Pb; heavy metal lead; imaging; in vivo; inhibitor; inhibitor/antagonist; malignancy; malignant breast neoplasm; mammary; mammary tumor; milk agent; mouse model; mutant; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; nonmalignant; novel; nuclease; ontogeny; osteopontin; overexpression; p300; pRB; pathway; phosphoprotein I, 2aR; prevent; preventing; protein complex; protein expression; regulatory gene product; response; scaffold; scaffolding; secreted phosphoprotein 1; siRNA; sialoprotein 1; skeletal; social role; transcription factor; transcriptome; tumor growth; tumor progression; tumorigenic; v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; vascular",NUCLEAR ORGANIZATION OF TRANSCRIPTIONAL DOMAINS IN BREAST CANCER,,82834,ZCA1,Special Emphasis Panel,,10,,265484
8017466,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA082834-10,9001,,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"NICKERSON, JEFFREY A;",1862714;,5P01CA082834,,,"Analysis, Data; Arts; Binding; Binding (Molecular Function); Cells; Computer Programs; Computer software; Computers; Confocal Microscopy; Consultations; Data Analyses; Electron Microscopy; Electrons; Equipment; Experimental Designs; FRET; Fluorescence; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; Gene Expression; Image; Investigators; Life; Measures; Methods and Techniques; Methods, Other; Microscope; Microscopic; Microscopy; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular Interaction; Negative Beta Particle; Negatrons; Nuclear Structure; Nucleic Acids; Preparation; Proteins; Protocol; Protocols documentation; Publications; Research Personnel; Researchers; Resolution; SP1; SP1 gene; Sampling; Scientific Publication; Services; Software; Techniques; Time; Training; Transcription Factor Sp1 Gene; base; cell imaging; cellular imaging; computer imaging; computer program/software; digital imaging; gene product; image processing; imaging; instrument; protein protein interaction",MICROSCOPY CORE,,82834,ZCA1,Special Emphasis Panel,,10,,141723
7760872,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,,NCI:1174562;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HAYWARD, GARY S;",1885946;,5P01CA113239,04/03/2006,01/31/2011,,Role of KSHV in AIDS Malignancies,,113239,NCI,Subcommittee E - Prevention & Control,,5,1174562,
8018146,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,0001,,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HAYWARD, GARY S;",1885946;,5P01CA113239,,,"21+ years old; 3-D; 3-Dimensional; 7B4 Antigen; 7B4 protein; AIDS; ATGN; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Adhesions; Adult; Affect; Africa, Southern; Antibodies; Antigens; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Assay; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; BB2; Bioassay; Biologic Assays; Biological; Biological Assay; Blotting, Northern; Body Tissues; Bundling; CD144 Antigen; CD31; CD54; CDH5; Cancers; Cell Culture Techniques; Cell Death, Programmed; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromosome Mapping; Clotting; Coagulation; Coagulation Process; Complementary DNA; Custom; DNA, Complementary; Dermal; Dimensions; Down-Regulation; Down-Regulation (Physiology); Downregulation; E3 Ligase; E3 Ubiquitin Ligase; Ectopic Expression; Endothelial Cells; Endothelial Cells, Lymphatic; Evaluation; Event; Follow-Up Studies; Followup Studies; Gene Chips; Gene Expression; Gene Expression Chip; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Transcription; Generalized Growth; Generations; Genes; Genes, Reporter; Genes, Viral; Genetic; Genetic Transcription; Genetics, Gene Mapping; Goals; Growth; HHV-8; HHV8; Herpesviridae Infections; Herpesviridae disease; Herpesvirus Infections; Human, Adult; ICAM-1 Gene; ICAM1; ICAM1 gene; IHC; Immune; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; Individual; Infection; Inflammatory; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Knock-out; Knockout; Label; Lesion; Linkage Mapping; Lymphatic; Lymphatic Endothelial Cells; Lytic; Lytic Cycle; Lytic Infection; Lytic Phase; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Maps; Mediating; Membrane; Messenger RNA; Metabolic; Names; Northern Blotting; Northern Blottings; Orphan; PECAM1; PECAM1 gene; Patients; Pattern; Peptide Domain; Phenotype; Primer Extension; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Analysis; Protein Domains; Proteins; RNA Expression; RNA Splicing; RNA blot analysis; RNA blotting; RNA, Messenger; RNA, Small Interfering; RT-PCR; RTPCR; Regulatory Protein; Relative; Relative (related person); Reporter Genes; Reverse Transcriptase Polymerase Chain Reaction; Ristocetin Cofactor; Ristocetin-Willebrand Factor; Role; Small Interfering RNA; Southern Africa; Spindle Endothelial Cell; Splicing; Subcellular Process; System; System, LOINC Axis 4; Tertiary Protein Structure; Time; Tissue Growth; Tissues; Transcript; Transcription; Transcription, Genetic; Ubiquitin-Protein Ligase E3; VE-Cadherin; Vascular Endothelial Cadherin; Vascular Endothelial Cadherin 1; Vascular Endothelial Cell; Viral; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Proteins; Virion; Virus Particle; Virus-HHV8; adult human (21+); cDNA; cDNA Library; cadherin 5; cultured cell line; cytokine; design; designing; experiment; experimental research; experimental study; functional status; gene product; genetic mapping; genetic regulatory protein; human herpesvirus 8; immunogen; in vivo; mRNA; mRNA Expression; malignancy; membrane structure; monolayer; mutant; neoplasm/cancer; neovascular; novel; ontogeny; podoplanin; programs; protein expression; reactivation from latency; regulatory gene product; research study; response; reverse transcriptase PCR; siRNA; skin lesion; social role; tumor; ubiquitin-protein ligase; vWF; virus protein; von Willebrand Factor; von Willebrand Protein",P-1:KSHV Latency and Reactivation in DMVEC Spindle Cells,,113239,NCI,Subcommittee E - Prevention & Control,,5,,297999
8018147,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,0002,,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HAYWARD, S DIANE;",1885287;,5P01CA113239,,,"AFLH; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Angiofollicular Lymphoid Hyperplasia; Angiolymphoid hyperplasia; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-EBP Nuclear Protein; C-EBP Proteins; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancers; Castleman Disease; Castleman's Tumor; Catenin, Beta-1; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromosomes; Clinical; DNA; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA-Methyltransferases; Deoxyribonucleic Acid; Development; Dnmt; EBV latency; EC 2; EC 2.1.1.113; EFF; Ensure; Epstein-Barr Virus latency; Evaluation; GLNH; Gene Action Regulation; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Targeting; Gene Transcription; Genes; Genes, Regulator; Genetic Transcription; Genome; Germinoblastoma; Giant Lymph Node Hyperplasia; HDAC; HDAC Proteins; HHV-8; HHV8; Histone Deacetylase; Histones; Immunologic Deficiency Syndrome, Acquired; Incidence; Individual; Infection; Investigation; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Knock-out; Knockout; LANA (antigen); Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; MeCP-2 protein; MeCP2; MeCP2 protein; Mediating; Methyl CpG Binding Protein 2; Methyl CpG binding protein (MeCP2); Methyl CpG binding protein MeCP2; Methyl-CpG binding protein 2; Methyl-CpG-Binding Protein 2; Methyl-DNA binding protein MECP2; Methylation; Modification Methylases; Molecular Interaction; Multiple Hemorrhagic Sarcoma; ORF73 gene product; P 2 (virucide); P-2; PRO2286; Pathogenesis; Pathway interactions; Patients; Process; Processed Genes; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Methylation; Proteins; RNA Expression; RNA, Small Interfering; Recruitment Activity; Regulation; Regulator Genes; Reporting; Repression; Research Specimen; Reticulolymphosarcoma; Role; Sampling; Sarcoma, Germinoblastic; Site-Specific DNA-methyltransferase; Small Interfering RNA; Specimen; Targetings, Gene; Testing; Time; Tissues; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Regulatory Elements; Transcriptional Repression; Transferase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral Genome; Virus-HHV8; beta catenin; cultured cell line; effusion; gene product; gene repression; human herpesvirus 8; inhibitor; inhibitor/antagonist; insight; latency-associated nuclear antigen; malignancy; methyl-CpG (cytosine-guanine dinucleotide) binding protein 2; neoplasm/cancer; novel; pathway; recruit; regulatory gene; siRNA; social role; trans acting element; transcription factor; tumor",P-2: LANA-1 mediated negative regulation of gene expression,,113239,NCI,Subcommittee E - Prevention & Control,,5,,300509
8018148,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,0003,,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"NICHOLAS, JOHN ;",1862126;,5P01CA113239,,,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; AIDS; Aacidexam; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adexone; Agonist; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anemul mono; Antimicotico; Antiviral Agents; Antiviral Drugs; Antivirals; Apoptotic; Aquapred; Associated Viruses; Autocrine Communication; Autocrine Signaling; Autocrine Systems; Auxiloson; Azona; B blood cells; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; B-Cells; B-Lymphocytes; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Baycuten; Baycuten N; Binding; Binding (Molecular Function); Blood Serum; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CCL1; CCL1 gene; CCR8; CCR8 gene; CKR-L1; CKRL1; CMKBR8; CMKBRL2; CY6; Cancers; Catalytic RNA; Cell Communication and Signaling; Cell Culture System; Cell Culture Techniques; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Corson; Cortidexason; Cortisumman; Coupled; Cytokines, Chemotactic; Data; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Detection; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Differentiation Factor, B-Cell; Dinormon; Disease; Disorder; EFF; Endothelial Cells; Engineering; Engineerings; Ensure; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; GPR-CY6; Gammacorten; Generations; Genes; Germinoblastoma; HHV-8; HHV8; HPGF; Hepatocyte-Stimulating Factor; Hexadecadrol; Hexadrol; Homologous Chemotactic Cytokines; Hybridoma Growth Factor; I-309; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Immune; Immune system; Immunologic Deficiency Syndrome, Acquired; In Vitro; Infection; Intercrines; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Knock-out; Knockout; Lentiviral Vector; Lentivirus Vector; Ligands; Lokalison-F; Loverine; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lytic; Lytic Cycle; Lytic Infection; Lytic Phase; MCL1 protein; MGI-2; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Maps; Mcl-1 protein; Measurement; Measures; Mediating; Methylfluorprednisolone; Mice; Millicorten; Molecular; Molecular Interaction; Multiple Hemorrhagic Sarcoma; Multiple Myeloma; Murine; Mus; Myeloid Differentiation-Inducing Protein; Myeloma, Plasma-Cell; Mymethasone; ORFs; Ocasa; Open Reading Frames; Orgadrone; P500; Pathogenesis; Phenotype; Plasmacytoma Growth Factor; Play; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Coding Region; Proteins; RNA, Small Interfering; Receptor Protein; Recombinants; Reporting; Reticulolymphosarcoma; Ribozymes; Role; SCYA1; SIS cytokines; SISe; Sarcoma, Germinoblastic; Satellite Viruses; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Specific qualifier value; Specified; Spersadex; Spersadox; Staging; System; System, LOINC Axis 4; TCA3; TER1; Telomerase; Testing; Therapeutic Agents; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Pathogenesis; Viral Physiology; Virus; Virus Diseases; Virus Replication; Virus-HHV8; Viruses, General; Visumetazone; Withdrawal; Work; auricularum; autocrine; base; biological signal transduction; body system, allergic/immunologic; cell growth; chemoattractant cytokine; chemokine; chemokine receptor; cytokine; disease/disorder; effusion; extracellular; gene product; human herpesvirus 8; in vivo; induced myeloid leukemia cell differentiation protein Mcl-1; inhibitor; inhibitor/antagonist; interferon beta 2; lytic gene expression; lytic replication; lytic viral replication; lytic virus replication; malignancy; myeloid cell factor-1; myeloid cell leukemia sequence 1; myeloma; myelomatosis; neoplasm/cancer; organ system, allergic/immunologic; paracrine; programs; receptor; recombinant virus; siRNA; social role; tumor growth; viral infection; virus infection; virus multiplication",P-3:Viral Chemokine signalling in HHV-8 infection,,113239,NCI,Subcommittee E - Prevention & Control,,5,,308858
8018149,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,9001,,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"DESAI, PRASHANT ;",1862553;,5P01CA113239,,,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Assay; Automobile Driving; B blood cells; B-Cells; B-Lymphocytes; Bacteriophage lambda; Bacteriophages; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Cell Culture Techniques; Cell Line; Cell Lines, Strains; CellLine; Cells; Clinical; Coliphage lambda; Collaborations; Collection; Communities; Complement; Complement Proteins; Complementary DNA; Custom; DNA; DNA Data Banks; DNA Databanks; DNA Databases; DNA, Complementary; Data Banks; Data Base Management; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, DNA; Deoxyribonucleic Acid; Dermal; Drivings, Automobile; Endothelial Cells; Enterobacteria phage lambda; Equipment and supply inventories; Evaluation; Freezing; Generations; Genes; Genetic; Genetics-Mutagenesis; Genome; Genomics; Goals; HHV-8; HHV8; History; Human; Human Resources; Human, General; Immunologic Deficiency Syndrome, Acquired; Individual; International; Inventory; Investigation; Investigators; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Knock-out; Knockout; Laboratories; Libraries; Lytic Cycle; Lytic Infection; Lytic Phase; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Manpower; Maps; Mediation; Messenger RNA; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Molecular Biology, Mutagenesis; Mutagenesis; NIH; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Phage lambda; Phages; Phenotype; Plant Embryos; Plasmids; Procedures; Production; RNA, Messenger; Reagent; Recording of previous events; Records; Research; Research Personnel; Researchers; Resource Sharing; Role; Sampling; Seeds; Source; System; System, LOINC Axis 4; Techniques; Technology; Telomerase; Tissues; Training; United States National Institutes of Health; Viral Genome; Virus; Virus-HHV8; Viruses, General; Work; Zygotes, Plant; bacterial genetics; bacterial virus; base; cDNA; cDNA Expression; cDNA Library; clinical data repository; clinical data warehouse; cultured cell line; data repository; driving; experience; expression cloning; expression vector; genetic manipulation; human herpesvirus 8; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; mRNA; malignancy; member; mutant; neoplasm/cancer; personnel; prototype; relational database; repair; repaired; seed; social role",C-B: KSHV Genetics,,113239,NCI,Subcommittee E - Prevention & Control,,5,,193485
8018150,P01,CA,5,,02/01/2010,01/31/2011,,5P01CA113239-05,9002,,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HAYWARD, GARY S;",1885946;,5P01CA113239,,,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Administrative Management; Analysis, Data; Articulation; Budgets; Cancer, Oncology; Cancers; Communication; Computer Graphics; Computers; Consultations; Contract Services; Custom; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Ensure; Equipment; Equipment and supply inventories; Fostering; HHV-8; HHV8; Human Resources; Immunologic Deficiency Syndrome, Acquired; Individual; Inventory; Investigators; Joints; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Laboratories; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Manpower; Manuscripts; NIH; National Institutes of Health; National Institutes of Health (U.S.); Office of Administrative Management; Operation; Operative Procedures; Operative Surgical Procedures; P01 Mechanism; P01 Program; Personnel Management; Preparation; Production; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Progress Reports; Protocol; Protocols documentation; Publications; Publishing; Reagent; Reporting; Reports, Progress; Research; Research Personnel; Research Program Projects; Research Resources; Researchers; Resource Allocation; Resources; Role; SCHED; Schedule; Scientific Publication; Services; Supervision; Surgical; Surgical Interventions; Surgical Procedure; Training; United States National Institutes of Health; Viral; Virus-HHV8; Visit; clinical data repository; clinical data warehouse; computer network; data management; data repository; human herpesvirus 8; lecturer; malignancy; meetings; neoplasm/cancer; oncology; personnel; programs; relational database; repair; repaired; social role; surgery",C-A: Administration Core,,113239,NCI,Subcommittee E - Prevention & Control,,5,,73711
7754684,P01,CA,5,,01/19/2010,12/31/2010,,5P01CA117969-05,,NCI:1899242;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"DEPINHO, RONALD ANTHONY;",1867055;,5P01CA117969,04/15/2006,12/31/2010,,Genetics and Biology of Pancreatic Duct Adenocarcinoma,,117969,NCI,Subcommittee E - Prevention & Control,,5,1899242,
8015366,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,0001,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"DEPINHO, RONALD ANTHONY;",1867055;,5P01CA117969,,,"19q13; AKT2; AKT2 gene; Abscission; Adenocarcinoma; Adenocarcinoma Cell; Adenoma, Malignant; Alleles; Allelomorphs; Anchorage-Independent Growth; Anti-Oncogenes; Antibodies; Antioncogenes; Apoptosis; Apoptosis Pathway; Assay; Automobile Driving; Benchmarking; Best Practice Analysis; Bioassay; Biochemical; Biologic Assays; Biologic Characteristic; Biological; Biological Assay; Biological Characteristics; Biological Function; Biological Models; Biological Process; Biology; Body Tissues; Canal of Wirsung; Cancer Gene Mutation; Cancer Genes; Cancer stem cell; Cancer-Promoting Gene; Cancers; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Line, Tumor; Cell Signaling; Cells; Characteristic, Biologic; Clinical; Collaborations; Complement; Complement Proteins; DNA; DNA Alteration; DNA mutation; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Detectable Residual Disease; Development; Drivings, Automobile; Elements; Emerogenes; Employee Strikes; Engineering; Engineerings; Evaluation; Event; Evolution; Excision; Experimental Pathology; Extinction; Extinction (Psychology); Extirpation; Foundations; Frequencies (time pattern); Frequency; Future; Gene Alteration; Gene Expression Profile; Gene Mutation; Gene Products, RNA; Gene Transcription; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic Markers; Genetic Transcription; Genetic defect; Genetic mutation; Genetically Engineered Mouse; Genome Scan; Genome Stability; Genomics; Genotype; Goals; Heterograft; Host-Tumor Interaction; Human; Human Cell Line; Human, General; Image; Imaging Device; Imaging Tool; Infrastructure; Intracellular Communication and Signaling; Lesion; Maintenance; Maintenances; Malignant Cell; Malignant Glandular Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measures; Mediating; Mice; Minimal Residual Disease; Model System; Modeling; Models, Biologic; Molecular; Murine; Mus; Mutation; Neoplasm, Residual; Nucleic Acids; ORFs; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Open Reading Frames; P53; PKBbeta; PRKBB; Pancreas Ductal Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pancreatic duct; Pathway interactions; Phenotype; Prevalence; Principal Investigator; Process; Protein Coding Region; Proteins; RAC-BETA; RAC-PK-Beta; RNA; RNA Expression; RNA, Non-Polyadenylated; Recurrence; Recurrent; Removal; Research Infrastructure; Research Resources; Research Specimen; Residual Neoplasm; Resistance profile; Resistant profile; Resolution; Resources; Ribonucleic Acid; Role; Sampling; Sequence Alteration; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Stability, Genomic; Staging; Strikes; Strikes, Employee; Surface; Surgical Removal; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Technology; Testing; Tet; Tetanus Helper Peptide; Tissue Model; Tissues; Trans-Acting Factors; Trans-Activators; Transactivators; Transcription; Transcription, Genetic; Transforming Genes; Transgenes; Transplantation, Heterologous; Tumor Angiogenesis; Tumor Biology; Tumor Cell Line; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Validation; Work; Xenograft; Xenograft procedure; Xenotransplantation; base; behavioral extinction; biobank; biological signal transduction; cancer cell; clinical data repository; clinical data warehouse; cohort; combinatorial; data repository; driving; gene discovery; gene expression signature; gene product; genome mutation; host neoplasm interaction; human disease; human tissue; imaging; in vivo; loss of function; malignancy; molecular imaging; mouse model; neoplasm/cancer; novel; oncosuppressor gene; pathway; polyclonal antibody; relational database; repository; resection; response; social role; stem; therapeutic target; trans acting factor (genetic); transcriptome; tumor; tumorigenesis",Genetic Pathways Governing Pancreatic Ductal Adenocarcinoma,,117969,NCI,Subcommittee E - Prevention & Control,,5,,221884
8015367,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,0002,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"CANTLEY, LEWIS C;",1883495;,5P01CA117969,,,"1-Phosphatidylinositol 4-Kinase; 19p; 70-kDa Ribosomal Protein S6 Kinases; AKT; AKT2; AKT2 gene; ATP-protein phosphotransferase; ATP[{..}]1-phosphatidyl-1D-myo-inositol-4-phosphotransferase; Adenocarcinoma; Adenocarcinoma Cell; Adenoma, Malignant; Akt protein; Alleles; Allelomorphs; Animals; Anti-Oncogenes; Antibodies; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Antigenic Determinants; Antimorphic mutation; Antioncogenes; Apoptosis; Apoptosis Pathway; Athymic Nude Mouse; Attenuated; Autocrine Systems; Behavior; Binding; Binding (Molecular Function); Binding Determinants; Biochemical; Biological; Biology; Blotting, Western; Body Tissues; C-K-RAS; Canal of Wirsung; Cancer Genes; Cancer stem cell; Cancer-Promoting Gene; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Cycle Progression; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Line, Tumor; Cell Lineage; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Chromosome 19 Proximal Arm; Chromosome 19 Short Arm; Chromosomes; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Critical Paths; Critical Pathways; DNA Alteration; DNA mutation; DPC4; Defect; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Duct Dysplasia of the Pancreas; Ductal Dysplasia of the Pancreas; EC 2.7; EC 2.7.1.67; ERK1; Embryo; Embryonic; Emerogenes; Engineering; Engineerings; Epitopes; Evaluation; Event; Exhibits; Experimental Pathology; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family member; Future; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GFAC; GTP GDP exchange factor; Gastrointestinal Tract, Pancreas; Gene Alteration; Gene Mutation; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Genetic mutation; Genomics; Goals; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Heterograft; Human; Human Cell Line; Human, General; IHC; Image; Imaging technology; Immunoblotting; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigation; Isoforms; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Kinases; Lead; Lesion; Life; Liver; MAD Homolog 4 Gene; MADH4; MADH4 gene; MAP-ERK Kinase; MAPK ERK Kinases; MAPK3; MAPK3 gene; MEKs; MYC Family Protein; MYC Protein; Maintenance; Maintenances; Malignant Glandular Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Athymic; Mice, Nude; Mirza; Mitogen-Activated Protein Kinase 3 Gene; Modeling; Molecular Interaction; Mothers Against Decapentaplegic Homolog 4; Murine; Mus; Muscle; Muscle Tissue; Mutation; NPIK; Neoplasm Metastasis; Network Analysis; Nude Mice; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P44ERK1; P44MAPK; P53; PI 4-Kinase; PI4K-Beta; PI4K92; PI4KBeta; PIK4CB; PKB protein; PKBbeta; PRKBB; PTK Receptors; PanIN; Pancreas; Pancreas Adenocarcinoma; Pancreas Ductal Adenocarcinoma; Pancreatic; Pancreatic Adenocarcinoma; Pancreatic Duct Dysplasia; Pancreatic Ductal Adenocarcinoma; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic duct; Pathogenesis; Pathway Analysis; Pathway interactions; Pb element; Perinatal; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Phosphatidyl Inositol; Phosphatidylinositiol Kinase; Phosphatidylinositol 4-Kinase; Phosphatidylinositol 4-Kinase Beta; Phosphatidylinositol 4-Kinase, Catalytic, Beta; Phosphatidylinositol 4-Kinase, Type III, Beta; Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive; Phosphatidylinositol Kinase Type II; Phosphatidylinositols; Phospho-Specific Antibodies; Phosphoinositide Kinase; Phosphoinositide Pathway; Phosphoinositide-4-Kinase Catalytic Beta Polypeptide; Phosphoinositides; Phosphoinositides and their downstream targets; Phosphopeptide-Specific Antibodies; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Phosphotransferases; Physiologic; Physiological; Play; Primary Neoplasm; Primary Tumor; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase; Protein Kinase B; Proteins; Proto-Oncogene Proteins c-akt; PtdIns; PtdIns 4-Kinase; RAC-BETA; RAC-PK protein; RAC-PK-Beta; RAFT1 protein, human; RAPT1 protein, human; RASK2; RTK; Rapamycin Target Protein; Reagent; Receptor Protein-Tyrosine Kinases; Reporter; Reporting; Research Specimen; Resistance; Resolution; Ribosomal Protein S6 Kinases, 70-kDa; Role; SMAD4; SMAD4/DPC4 Gene; Secondary Neoplasm; Secondary Tumor; Sequence Alteration; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Solid Neoplasm; Solid Tumor; Sorting - Cell Movement; Specimen; Staging; Staining method; Stainings; Stains; Stains, Tissue; TP53; TP53 gene; TRP53; TSC2 protein; TSC2 protein, human; Testing; Therapeutic; Therapeutic Intervention; Tissue Growth; Tissue Stains; Tissues; Transforming Genes; Transgenic Organisms; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Transplantation; Transplantation, Heterologous; Tuberin; Tuberous Sclerosis 2 Protein; Tumor Cell Line; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Western Blotting; Western Blottings; Western Immunoblotting; Work; Xenograft; Xenograft procedure; Xenotransplantation; angiogenesis; autocrine; biobank; biological signal transduction; biomarker; body system, hepatic; c-akt protein; cancer genomics; cancer metastasis; cancer progression; cell growth; cell transformation; clinical investigation; combinatorial; cultured cell line; disease/disorder; drug development; exchange factor; experiment; experimental research; experimental study; gene product; genetic analysis; genetic profiling; genome mutation; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human FRAP1 protein; human TSC2 protein; human tissue; hydroxyalkyl protein kinase; imaging; improved; inhibitor; inhibitor/antagonist; intervention therapy; mTOR; mTOR Inhibitor; malignancy; meetings; mouse model; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; oncosuppressor gene; ontogeny; organ system, hepatic; p70 S6 Kinase; p70s6k; pathway; phosphorylase b kinase kinase; polyclonal antibody; prevent; preventing; programs; protein blotting; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; recombinase; related to A and C-protein; research study; resistant; response; shRNA; short hairpin RNA; small hairpin RNA; small molecule; social role; sorting; transformed cells; transgenic; transplant; tuberin, TSC2; tumor; tumor progression; tumorigenesis; tumorigenic; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; vector",The RAS and P13K Pathways in Pancreatic Adenocarcinoma,,117969,NCI,Subcommittee E - Prevention & Control,,5,,393191
8015368,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,0003,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"HANAHAN, DOUGLAS ;",1865947;,5P01CA117969,,,"1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; 1-Phosphatidylinositol 3-Kinase; 2',2'-DFDC; 2',2'-difluoro-2'-deoxycytidine; 2',2'-difluorodeoxycytidine; 2'-deoxy-2'-difluorocytidine; 2'Deoxy-2',2'-Difluorocytidine; 2,2 difluorodexoycytidine; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Adenocarcinoma; Adenoma, Malignant; Adventitial Cell; Affect; Alleles; Allelomorphs; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Angiogenesis Modulators; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Anti-Oncogenes; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Antioncogenes; Articulation; B9 endocrine pancreas; Biology; Biopsy; Blood; Blood Vessels; Blood leukocyte; C-K-RAS; CD140B; Canal of Wirsung; Cancer Induction; Cancer stem cell; Cancers; Carcinoma; Cathepsins; Cell Communication and Signaling; Cell Components; Cell Signaling; Cell Structure; Cells; Cellular Structures; Characteristics; Clinical Trials; Clinical Trials Design; Clinical Trials, Therapy; Clinical Trials, Unspecified; Collaborations; Combined Modality Therapy; DNA Alteration; DNA mutation; DPC4; Data; Desmoplastic; Desmoplastic Reaction; Development; Difluorodeoxycytidine; Disease; Disease Progression; Disorder; Dose; Duct Dysplasia of the Pancreas; Ductal; Ductal Dysplasia of the Pancreas; EC 2.7; Emerogenes; Endothelial Cells; Engineering; Engineerings; Enzymes; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Experimental Pathology; Fibroblasts; Foundations; Future; Gastrointestinal Tract, Pancreas; Gene Alteration; Gene Mutation; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetically Engineered Mouse; Goals; HPSE; HPSE Protein; Heparanase-1; Human; Human, General; Image; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Innovative Therapy; Intervention Trial; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; JTK12; Joints; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Kinases; Knowledge; Lesion; Leukocytes; Lymphangiogeneses; Lymphangiogenesis; Lymphatic; MAD Homolog 4 Gene; MADH4; MADH4 gene; MMPs; Malignant Cell; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Matrix Metalloproteinases; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Molecular; Monitor; Morphology; Mother Cells; Mothers Against Decapentaplegic Homolog 4; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Mutation; Neoplasm Metastasis; Neovascularization Inhibitors; Nesidioblasts; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; P53; PDGF-R-Beta; PDGFR; PDGFR1; PDGFRB; PDGFRB gene; PI-3 Kinase; PI-3K; PI3-Kinase; PanIN; Pancreas; Pancreas Cancer; Pancreas, Endocrine; Pancreatic; Pancreatic Cancer; Pancreatic Duct Dysplasia; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic Islets; Pancreatic duct; Pars endocrina pancreatis; Pathology; Pathway interactions; Pericapillary Cell; Pericytes; Perivascular Cell; Phase; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Prevention; Principal Investigator; Procedures; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Protocol; Protocols documentation; PtdIns 3-Kinase; RASK2; Regimen; Regulation; Relapse; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Role; Rouget Cells; SMAD4; SMAD4/DPC4 Gene; Secondary Neoplasm; Secondary Tumor; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; Stromal Cells; TP53; TP53 gene; TRP53; Testing; Therapeutic Trials; Therapy Clinical Trials; Therapy, Innovative; Translating; Translatings; Transphosphorylases; Tumor Angiogenesis; Tumor Burden; Tumor Cell; Tumor Cell Migration; Tumor Load; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; VEGF Receptors; VEGFR; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Permeability Factor Receptor; White Blood Cells; White Cell; Work; angiogenesis; antiangiogenic; base; beta cell development; biobank; biological signal transduction; biomarker; cancer cell; cancer genetics; cancer metastasis; carcinogenesis; cell type; chemotherapy; clinical investigation; combination therapy; combined modality treatment; combined treatment; dFdC; dFdCyd; design; designing; disease/disorder; end stage disease; endocrine pancreas; endocrine pancreas development; epithelial carcinoma; experiment; experimental research; experimental study; gemcitabine; genome mutation; heparan sulphate endoglycosidase; heparanase; human disease; imaging; improved; innovate; innovation; innovative; islet development; islet progenitor; knowledge base; language translation; loss of function; malignancy; mouse model; multimodality therapy; neoplasm/cancer; neoplastic; neoplastic cell; neovasculature; oncosuppressor gene; pathway; pre-clinical; preclinical; preclinical study; programs; research study; response; social role; therapeutic target; tumor; tumor growth; tumor suppressor; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; vascular; white blood cell; white blood corpuscle",Mechanisms & Therapeutic Targeting of the Microenvironment in Pancreatic Cancer,,117969,NCI,Subcommittee E - Prevention & Control,,5,,307397
8015369,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,0004,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"JACKS, TYLER E;",3132351;,5P01CA117969,,,"21+ years old; Address; Adenocarcinoma; Adenoma, Malignant; Adult; Antibodies; Area; Biochemical; Biochemical Genetics; Biochemical Markers; Biological; Biology; Canal of Wirsung; Cancer stem cell; Cell Communication and Signaling; Cell Components; Cell Function; Cell Isolation; Cell Lineage; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cell Structure; Cell physiology; Cell surface; Cell/Tissue, Immunohistochemistry; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Structures; Data; Development; Diagnosis; Disease model; Duct Dysplasia of the Pancreas; Ductal Dysplasia of the Pancreas; EC 2.7; Early Diagnosis; Engineering; Engineerings; Evaluation; Experimental Pathology; Expression Profiling; Expression Signature; Gastrointestinal Tract, Pancreas; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Genomics; Goals; Heterograft; Human; Human, Adult; Human, General; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigation; Kinases; Knock-in; Knock-in Mouse; Lead; Lesion; Mammals, Mice; Man (Taxonomy); Man, Modern; Markers, Biochemical; Methods; Mice; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Mouse Strains; Murine; Mus; Mutation; Normal Tissue; Normal tissue morphology; Oncogenic; PanIN; Pancreas; Pancreas Neoplasms; Pancreatic; Pancreatic Duct Dysplasia; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic Tumor; Pancreatic duct; Pathway interactions; Pb element; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphotransferases; Population; Principal Investigator; Profilings, Gene Expression; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; PtdIns; Reagent; Recurrence; Recurrent; Relative; Relative (related person); Research Specimen; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sorting - Cell Movement; Specimen; Stem cells; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Therapeutic Studies; Therapy Research; Transcript Expression Analyses; Transcript Expression Analysis; Transgenes; Transphosphorylases; Transplantation, Heterologous; Tumor Tissue; Tumor of the Pancreas; Tumor-Derived; Viral Vector; Work; Xenograft; Xenograft procedure; Xenotransplantation; adult human (21+); base; biobank; biological signal transduction; cell sorting; cell type; disorder model; early detection; genome mutation; heavy metal Pb; heavy metal lead; imaging; improved; in vivo; insight; intervention therapy; microarray technology; molecuar profile; molecular imaging; molecular signature; mouse model; pancreatic neoplasm; pathway; programs; recombinase; response; social role; sorting; stem cell population; tool; tumor; tumorigenic",Investigation of the Cell-of-Origin and Cancer Stem Cells in Pancreatic Adenocarc,,117969,NCI,Subcommittee E - Prevention & Control,,5,,342779
8015370,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,9001,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"WEISSLEDER, RALPH ;",1891052;,5P01CA117969,,,"Address; Adenocarcinoma; Adenoma, Malignant; Animals; Bio-Informatics; Bioinformatics; Biology; Bioluminescence; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Canal of Wirsung; Chemistry; Collaborations; Communication; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Confocal Microscopy; Custom; Data; EMI scan; Esteroproteases; Expertise, Technical; Fluorescence; Genetic; Genetically Engineered Mouse; Genomics; Genotype; Goals; Group Meetings; Human Resources; Image; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; Imaging technology; Infrastructure; Institution; Investigators; Life; Link; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Manpower; Maps; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Medical Imaging, Single Photon Emission Computed Tomography; Meetings, Group; Methods and Techniques; Methods, Other; Mice; Microscopic; Microscopy, Confocal; Molecular; Mother Cells; Murine; Mus; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; On-Line Systems; Online Systems; P01 Mechanism; P01 Program; PET; PET Scan; PET imaging; PETSCAN; PETT; Pancreatic duct; Pathway interactions; Peptidases; Peptide Hydrolases; Phenotype; Positron Emission Tomography Scan; Positron-Emission Tomography; Principal Investigator; Progenitor Cells; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; Proteomics; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; Quality Control; ROC Analysis; Rad.-PET; Radionuclide Tomography, Single-Photon Emission-Computed; Reagent; Reporter; Research; Research Infrastructure; Research Personnel; Research Program Projects; Research Resources; Researchers; Resolution; Resources; SPECT; SPECT imaging; Science of Chemistry; Stem cells; System; System, LOINC Axis 4; Technical Expertise; Technics, Imaging; Techniques; Technology; Therapeutic Studies; Therapy Research; Tomodensitometry; Tomography, Emission-Computed, Single-Photon; Tomography, Xray Computed; Transgenic Organisms; Treatment Efficacy; X-Ray Computed Tomography; Zeugmatography; angiogenesis; base; biomarker; cancer progression; catscan; computed axial tomography; computerized axial tomography; computerized tomography; cost; design; designing; experiment; experimental research; experimental study; fluorescence imaging; image evaluation; imaging; imaging probe; innovate; innovation; innovative; meetings; molecular imaging; mouse model; neoplasm progression; neoplastic progression; novel; online computer; pathway; personnel; programs; research study; success; therapeutic efficacy; therapeutically effective; tomography; transgenic; tumor progression; web based",Core A: Molecular Imaging Core,,117969,NCI,Subcommittee E - Prevention & Control,,5,,254900
8015371,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,9002,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"REDSTON, MARK ;",8451074;,5P01CA117969,,,"1-Phosphatidylinositol 3-Kinase; 19q13; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adenocarcinoma; Adenocarcinoma Cell; Adenoma, Malignant; Alleles; Allelomorphs; Anatomic; Anatomical Sciences; Anatomy; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Assay; Autopsy; Banking, Tissue; Bioassay; Biologic Assays; Biologic Marker; Biological Assay; Biological Markers; Biological Models; Biology; Body Tissues; Canal of Wirsung; Cancer Induction; Cancer stem cell; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cellularity; Clinical Trials, Therapy; Collaborations; Collection; Colony-Forming Units, Neoplastic; Consultations; DISSEC; Development; Dissection; Duct; Duct (organ) structure; Duct Dysplasia of the Pancreas; Ductal; Ductal Dysplasia of the Pancreas; Engineering; Engineerings; Ensure; Environment; Epithelial; Epithelial Dysplasia; Evaluation; Experimental Pathology; Expertise, Technical; FISH Technic; FISH Technique; FISH analysis; Fluorescent in Situ Hybridization; Fostering; Freezing; Frequencies (time pattern); Frequency; Future; Gastrointestinal Tract, Pancreas; Genes; Genes, p53; Genetic; Genetically Engineered Mouse; Genomics; Genotype; Goals; Heterograft; Histology; Human; Human, General; Image; Image Analyses; Image Analysis; In Situ Hybridization, Fluorescence; Infrastructure; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intracellular Communication and Signaling; Intraepithelial Neoplasia; Intraepithelial Neoplasms; Investigation; Investigators; Lesion; Link; Malignant Glandular Cell; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Method LOINC Axis 6; Methodology; Mice; Microdissection; Microscopic; Moab, Clinical Treatment; Model System; Modeling; Models, Biologic; Molecular; Molecular Analysis; Molecular Marker; Monoclonal Antibodies; Mother Cells; Murine; Mus; Neoplasm Metastasis; Neoplasms; Neovascularization Inhibitors; Outcome; P53; PI-3 Kinase; PI-3K; PI3-Kinase; PanIN; Pancreas; Pancreas Cancer; Pancreas Ductal Adenocarcinoma; Pancreas Neoplasms; Pancreatic; Pancreatic Cancer; Pancreatic Duct Dysplasia; Pancreatic Ductal Adenocarcinoma; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic Tumor; Pancreatic duct; Paraffin; Paraffin Embedding; Paraffin Tissue; Paraffin waxes and Hydrocarbon waxes; Pathologic; Pathology; Pathway interactions; Performance; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Population; Position; Positioning Attribute; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; PtdIns 3-Kinase; Quality Control; RNA analysis; ROC Analysis; Radiology; Radiology Specialty; Radiology, General; Research; Research Infrastructure; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Role; Sampling; Science of Anatomy; Screening procedure; Secondary Neoplasm; Secondary Tumor; Series; Services; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signature Molecule; Slide; Specimen; Staining method; Stainings; Stains; Stem Cells, Neoplastic; Stem cells; Supervision; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Technical Expertise; Technology; Testing; Therapeutic Trials; Therapy Clinical Trials; Tissue Arrays; Tissue Banking; Tissue Banks; Tissue Chip; Tissue Collection; Tissue Harvesting; Tissue Microarray; Tissue Sample; Tissue, Paraffin; Tissue/Specimen Collection; Tissues; Transplantation, Heterologous; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Stem Cells; Tumor of the Pancreas; Tumor-Derived; Tumors; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Unresectable; Validation; Work; Xenograft; Xenograft procedure; Xenotransplantation; anatomy; antiangiogenic; base; biobank; biological signal transduction; biomarker; cancer metastasis; cancer progression; carcinogenesis; cell imaging; cellular imaging; cryostat; design; designing; experiment; experimental research; experimental study; flexibility; gene discovery; gene product; human tissue; image evaluation; imaging; imaging modality; improved; innovate; innovation; innovative; insight; laser capture microdissection; malignancy; meetings; molecular pathology; molecular/cellular imaging; mouse model; necropsy; neoplasia; neoplasm progression; neoplasm/cancer; neoplastic; neoplastic growth; neoplastic progression; new diagnostics; new technology; new therapeutic target; next generation diagnostics; novel; novel diagnostics; pancreatic neoplasm; pathway; postmortem; pre-clinical; preclinical; programs; research study; screening; screenings; social role; stem; stem cell population; success; tissue processing; tool; tumor; tumor progression; tumor xenograft",Experimental Pathology Core,,117969,NCI,Subcommittee E - Prevention & Control,,5,,179790
8015372,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,9003,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"THAYER, SARAH P;",7851379;,5P01CA117969,,,"Adenocarcinoma; Adenoma, Malignant; Anti-Oncogenes; Antioncogenes; Biocompatible Materials; Biology; Biomaterials; Canal of Wirsung; Cancers; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellularity; Collaborations; Collection; Communication; DNA Alteration; DNA mutation; Disseminated Malignant Neoplasm; Ductal Cell; Ductal Epithelial Cell; Emerogenes; Ensure; Experimental Pathology; Expression Profiling; Expression Signature; Fostering; Gastrointestinal Tract, Pancreas; Gene Alteration; Gene Mutation; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic mutation; Genomics; Goals; Heterograft; Histologic; Histologically; Human; Human, General; Information Services; Investigators; Laboratories; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Metastatic Cancer; Metastatic Malignant Neoplasm; Mice; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Operation; Operative Procedures; Operative Surgical Procedures; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pancreatic duct; Parents; Participant; Population; Preparation; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Quality Control; Relative; Relative (related person); Research; Research Personnel; Research Resources; Research Specimen; Researchers; Resolution; Resources; Sampling; Sequence Alteration; Specimen; Staging; Standardization; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Translations; Transplantation, Heterologous; Tumor Cell; Tumor Suppressing Genes; Tumor Suppressor Genes; Xenograft; Xenograft procedure; Xenotransplantation; anticancer research; biobank; cancer research; cultured cell line; data management; design; designing; experiment; experimental research; experimental study; human tissue; malignancy; meetings; member; molecuar profile; molecular signature; mouse model; neoplasm/cancer; neoplastic cell; oncosuppressor gene; programs; repository; research data dissemination; research study; surgery; tumor",Core C: Biobank Core,,117969,NCI,Subcommittee E - Prevention & Control,,5,,159869
8015373,P01,CA,5,,01/01/2010,12/31/2010,,5P01CA117969-05,9004,,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"DECAPRIO, JAMES A;",1945115;,5P01CA117969,,,"ATGN; Adenocarcinoma; Adenocarcinoma Cell; Adenoma, Malignant; Analysis, Data; Animal Housing; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Antigens; Basic Research; Basic Science; Binding Determinants; Biological Preservation; Biology; Blotting, Western; Body Tissues; Canal of Wirsung; Cancer Center; Cancer stem cell; Cataloging; Catalogs; Cell Line; Cell Lines, Strains; Cell Surface Antigens; Cell surface; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Clinic; Cytofluorometry, Flow; DF/HCC; Dana-Farber Cancer Institute; Data Analyses; Diagnosis; Diagnostic; Disease; Disorder; Drug toxicity; Duct Dysplasia of the Pancreas; Ductal Dysplasia of the Pancreas; Epitopes; Experimental Designs; Fee Schedules; Fees; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Formalin; Freezing; Generations; Genetic; Goals; Housing, Animal; Human; Human, General; Hybridomas; IHC; Immunization; Immunofluorescence; Immunofluorescence Immunologic; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Stimulation; Immunologic, Immunofluorescence; Immunological Stimulation; Immunostimulation; Investigators; Laser Scanning Cytometry; Malignant Glandular Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Markers, Surrogate; Mice; Microfluorometry, Flow; Mission; Moab, Clinical Treatment; Molecular; Monoclonal Antibodies; Murine; Mus; PanIN; Pancreas Ductal Adenocarcinoma; Pancreatic Duct Dysplasia; Pancreatic Ductal Adenocarcinoma; Pancreatic Ductal Dysplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic duct; Preparation; Preservation, Biologic; Preservation, Biological; Production; Programs (PT); Programs [Publication Type]; Proteins; Reagent; Research Personnel; Research Resources; Researchers; Resources; Scientist; Screening procedure; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction Pathway; Signaling Molecule; Sorting - Cell Movement; Specificity; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Surrogate Markers; Therapeutic; Tissues; Western Blotting; Western Blottings; Western Immunoblotting; Work; antibody biosynthesis; base; biomarker; clinical applicability; clinical application; cultured cell line; design; designing; disease/disorder; drug discovery; flow cytophotometry; gene product; immunogen; immunoglobulin biosynthesis; monoclonal antibody production; mouse model; novel; polyclonal antibody; preservation; programs; protein blotting; response; screening; screenings; sorting",PDAC Antibody Core,,117969,NCI,Subcommittee E - Prevention & Control,,5,,39432
7843566,P01,DA,5,,12/01/2009,11/30/2010,,5P01DA009789-13,,NIDA:1085698;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"WILEY, JENNY L.;",10526423;,5P01DA009789,09/01/1997,11/30/2013,,Endogenous Cannabinoids and Brain Function,,9789,ZDA1,Special Emphasis Panel,,13,1085698,
7754653,P01,DK,5,,12/01/2009,11/30/2010,,5P01DK011794-42,,NIDDK:1932682;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"POTTS, JOHN T;",1869644;,5P01DK011794,08/01/1997,11/30/2013,,HORMONAL CONTROL OF CALCIUM METABOLISM,,11794,ZDK1,Special Emphasis Panel,,42,1932682,
8017447,P01,DK,5,,,,,5P01DK011794-42,6848,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"GARDELLA, THOMAS J;",2202046;,5P01DK011794,,,"3'5'-cyclic ester of AMP; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adopted; Affinity; Amino Acids; Animals; Arrestins; Assay; Autoregulation; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Blood; Blood Coagulation Factor IV; Blood Plasma; Bone; Bone Formation; Bone Growth; Bone and Bones; Bones and Bone Tissue; Ca++ element; Calcium; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Coagulation Factor IV; Complex; Confocal Microscopy; Coupled; Cyclic AMP; Cytoplasmic Membrane; Data; Development; Disease; Disorder; Endocrine; Energy Transfer; Experimental Designs; Factor IV; G-Proteins; G-substrate; GTP gamma S; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPgammaS; Genetics-Mutagenesis; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine 5'-(3-O-Thio)Triphosphate; Guanosine 5'-(gamma-S)Triphosphate; Guanosine 5'-(trihydrogen diphosphate), P'-anhydride with phosphorothioic acid; Guanosine 5'-O-(3-Thiotriphosphate); Head and Neck, Thyroid; Homeostasis; Hormonal; Hypercalcemic Hormone of Malignancy; Hypoparathyroidism; Immunoelectron Microscopy; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Kinetic; Kinetics; Life; Ligand Binding; Ligands; Mammals, Mice; Maps; Mediating; Methods; Mice; Microscopy; Microscopy, Confocal; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Model System; Modeling; Models, Biologic; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Movement; Murine; Mus; Mutagenesis; N-terminal; NH2-terminal; Osteogenesis; Osteoporosis; PTH Like Tumor Factor; PTH(1-34); PTH-Like Protein; PTH-PTHrP Receptor; PTH-Related Peptide; PTH-Related Peptide Receptor; PTH-Related Protein Receptor; PTHLP Receptor; PTHrP; PTHrP Receptor; Parathyroid Hormone Like Tumor Factor; Parathyroid Hormone Receptor; Parathyroid Hormone Receptor 1; Parathyroid Hormone Receptor Type I; Parathyroid Hormone-Like Hormone; Parathyroid Hormone-Like Protein; Parathyroid Hormone-Related Peptide; Parathyroid Hormone-Related Peptide Receptor; Pattern; Peptides; Phosphates; Physiological Homeostasis; Plasma; Plasma Membrane; Play; Receptor Protein; Receptor, Parathyroid Hormone, Type 1; Receptor, Parathyroid Hormone-Like Peptide; Recombinant Parathyroid Hormone-Related Protein; Resolution; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Testing; Therapeutic; Thyroid; Thyroid Gland; Time; Tumor Hypercalcemic Factor; adenosine 3'5' monophosphate; aminoacid; analog; base; biological signal transduction; body movement; bone; cAMP; calcium metabolism; calcium phosphate; cell imaging; cellular imaging; cerebellum protein substrate for cGMP dependent protein kinase; coated pit; conformation; conformational state; disease/disorder; gamma-Thio-GTP; imaging modality; in vivo; inorganic phosphate; mouse model; next generation; novel; paracrine; parathyroid hormone (1-34); parathyroid hormone-related protein; plasmalemma; protein G; receptor; response; social role; trafficking",Interaction of PTH with the PTH-1 Receptor,,11794,ZDK1,Special Emphasis Panel,,42,,370795
8017448,P01,DK,5,,12/01/2009,11/30/2010,,5P01DK011794-42,6849,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"KRONENBERG, HENRY M;",1870227;,5P01DK011794,,,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; Abscission; Affect; Age; Anabolic Agents; Apoptosis; Apoptosis Pathway; Apoptotic; Birth; Blood Coagulation Factor IV; Bone; Bone Formation; Bone Resorption; Bone and Bones; Bones and Bone Tissue; Ca++ element; Calcium; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Coagulation Factor IV; Cytofluorometry, Flow; DEXA; DISSEC; DNA Synthesis Factor; Data; Development; Diet; Disease; Disorder; Dissection; Doxycycline; ECGF; Endothelial Cell Growth Factor; Excision; Extirpation; FGF; Factor IV; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fracture; Gene Expression; Generations; Genes; Genetic Models; Genetic analyses; Genetics, in situ Hybridization; Goals; HBGF; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Hormonal; Hypercalcemic Hormone of Malignancy; In Situ Hybridization; In Vitro; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Intracellular Second Messengers; Kidney; Knock-in; Knock-in Mouse; Knock-out; Knockout; Lecithinase C; Link; Mammals, Mice; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Microfluorometry, Flow; Modeling; Models, Genetic; Molecular; Murine; Mus; Mutate; ODF factor; OPGL protein; Organ; Osteoblasts; Osteoclast Differentiation Factor; Osteoclastic Bone Loss; Osteoclasts; Osteocytes; Osteogenesis; Osteoporosis; Osteoprotegerin Ligand; PTH Like Tumor Factor; PTH-Like Protein; PTH-PTHrP Receptor; PTH-Related Peptide; PTH-Related Peptide Receptor; PTH-Related Protein Receptor; PTHLP Receptor; PTHrP; PTHrP Receptor; Parathyroid Hormone Like Tumor Factor; Parathyroid Hormone Receptor; Parathyroid Hormone Receptor 1; Parathyroid Hormone Receptor Type I; Parathyroid Hormone-Like Hormone; Parathyroid Hormone-Like Protein; Parathyroid Hormone-Related Peptide; Parathyroid Hormone-Related Peptide Receptor; Partner in relationship; Parturition; Pathway interactions; Phospholipase C; Physiology; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RANK ligand; Receptor Activation; Receptor Activator of Nuclear Factor Kappa B Ligand; Receptor Protein; Receptor, Parathyroid Hormone, Type 1; Receptor, Parathyroid Hormone-Like Peptide; Recombinant Parathyroid Hormone-Related Protein; Removal; Role; Second Messenger Systems; Second Messengers; Serologic; Serological; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stromal Cells; Sum; Surgical Removal; TNF-Related Activation-Induced Cytokine; TRANCE protein; Tet; Tetanus Helper Peptide; Tetracycline Antibiotic; Tetracyclines; Time; Tumor Hypercalcemic Factor; Tumor Necrosis Factor Ligand Superfamily Member 11; Urinary System, Kidney; Vibramycin; Withdrawal; alpha-6-Deoxyoxytetracycline; biological signal transduction; bone; bone fracture; bone mass; calcium metabolism; disease/disorder; flow cytophotometry; genetic analysis; in situ Hybridization Staining Method; in vivo; in vivo Model; lipophosphodiesterase I; mate; mutant; osteoblast differentiation; parathyroid hormone-related protein; pathway; phosphatidylcholine cholinephosphohydrolase; receptor; recombinase; renal; resection; response; second messenger; social role",Genetic Analysis of Second Messengers in PTH Signaling in Bone,,11794,ZDK1,Special Emphasis Panel,,42,,394105
8017449,P01,DK,5,,12/01/2009,11/30/2010,,5P01DK011794-42,6850,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BRINGHURST, F RICHARD;",2062529;,5P01DK011794,,,"3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); Activation of PKC through G protein coupled receptor; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Apoptosis; Apoptosis Pathway; Autoregulation; Back; Biochemical Pathway; Blood Coagulation Factor IV; Blood Serum; Bone; Bone Formation; Bone and Bones; Bones and Bone Tissue; C protein; CBP protein (citrate-binding); Ca++ element; Calcium; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calvaria; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Continuous Infusion; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DEXA; DNA Binding; DNA Binding Interaction; Densitometry; Diet; Dorsum; Dose; EP300; EP300 gene; Exhibits; Exposure to; Factor IV; Fracture; Fracture, Pathologic; Fractures, Spontaneous; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Histology; Homeostasis; Hormonal; In Vitro; Intracellular Communication and Signaling; Intracellular Second Messengers; Ions; Knock-out; Knockout; Knockout Mice; Lecithinase C; Ligands; Link; Mammals, Mice; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Networks; Mice; Mice, Knock-out; Mice, Knockout; Minerals; Molecular; Murine; Mus; Mutation; Null Mouse; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; PKA; PKC; PTH (1-84); PTH protein, human; PTH-PTHrP Receptor; PTH-Related Peptide Receptor; PTH-Related Protein Receptor; PTHLP Receptor; PTHrP Receptor; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormone Receptor; Parathyroid Hormone Receptor 1; Parathyroid Hormone Receptor Type I; Parathyroid Hormone-Related Peptide Receptor; Parathyroid Hormones; Pathological fracture; Pathway interactions; Pattern; Phospholipase C; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physiological Homeostasis; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Property; Property, LOINC Axis 2; Protein Kinase A; Protein Kinase C; Protein Kinase C Activation Pathway; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor, Parathyroid Hormone, Type 1; Receptor, Parathyroid Hormone-Like Peptide; Relative; Relative (related person); Role; Second Messenger Systems; Second Messengers; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Subcellular Process; Testing; Therapeutic Effect; Therapeutic Uses; Vertebral Bone; Wild Type Mouse; Work; adenosine 3'5' monophosphate; adenylcyclase; analog; biological signal transduction; biomarker; bone; bone cell; bone fracture; bone mass; cAMP; cAMP-Dependent Protein Kinases; calcium metabolism; calcium phosphate; calvarial; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; cultured cell line; defined contribution; design; designing; feeding; gene product; genome mutation; hPTH(1-84); hormone analog; human PTH protein; in vitro Assay; in vivo; inhibitor; inhibitor/antagonist; insight; lipophosphodiesterase I; mouse model; mutant; novel; osteoclastogenesis; osteoprogenitor cell; p300; parathormone; parathyroid hormone, human; pathway; phosphatidylcholine cholinephosphohydrolase; response; second messenger; skeletal; social role; substantia spongiosa; substantia trabecularis; tomography; trabecular bone; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein",Second Messengers in PTH Action,,11794,ZDK1,Special Emphasis Panel,,42,,178974
8017450,P01,DK,5,,,,,5P01DK011794-42,6851,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"JUEPPNER, HARALD W.;",1862105;,5P01DK011794,,,"3'5'-cyclic ester of AMP; Actins; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Albright hereditary osteodystrophy; Albright hereditary osteodystrophy (AHO); Albright syndrome 1; Albright's hereditary osteodystrophy; Apical; Autoregulation; Blood Coagulation Factor IV; Ca++ element; Calcification, Pathologic; Calcinosis; Calcium; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell model; CellLine; Cells; Cellular Matrix; Cellular model; Chronic Kidney Failure; Chronic Renal Disease; Co-Transporters; Coagulation Factor IV; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal System; Cytoskeleton; Data; Diet; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Endocytosis; Excretory function; Factor IV; Familial hypophosphatemic bone disease; Fuller Albright syndrome 1; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hereditary; Homeostasis; Hormonal; Human; Human, General; Hydrolysis; Hyperparathyroidism, Secondary; Hypoparathyroidism; In Vitro; Inherited; Inositol Phosphates; Intracellular Communication and Signaling; Investigation; Kidney; Kidney Failure, Chronic; Kidney Tubules, Proximal; Knockout Mice; LLC-PK1 Cells; Lateral; Lead; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Mouse Strains; Murine; Mus; Mutation; NHE-RF protein; NHERF; Na+-H+ exchanger-regulatory factor; Null Mouse; PKA; PTH (1-84); PTH protein, human; PTH-PTHrP Receptor; PTH-Related Peptide Receptor; PTH-Related Protein Receptor; PTHLP Receptor; PTHrP Receptor; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormone Receptor; Parathyroid Hormone Receptor 1; Parathyroid Hormone Receptor Type I; Parathyroid Hormone-Related Peptide Receptor; Parathyroid Hormones; Pathway interactions; Patients; Pb element; Phosphates; Phosphorylation; Physiological Homeostasis; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Property; Property, LOINC Axis 2; Protein Kinase A; Protein Phosphorylation; Proteins; Proximal Kidney Tubules; Pseudohypoparathyroidism; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Receptor, Parathyroid Hormone, Type 1; Receptor, Parathyroid Hormone-Like Peptide; Regulation; Renal Failure, Chronic; Resistance; Rickets, Hypophosphatemic; Rickets, Vitamin D-Resistant; Role; Seabright Bantam syndrome; Secondary Hyperparathyroidism; Secondary Hyperparathyroidisms; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solubility; Stream; Surface; Tubular; Tubular formation; Urinary System, Kidney; X linked hypophosphatemia in rickets; X-Linked Hypophosphatemic Rickets; adenosine 3'5' monophosphate; base; basolateral membrane; biological signal transduction; brush border membrane; cAMP; cAMP-Dependent Protein Kinases; calcium metabolism; chronic kidney disease; cultured cell line; disease/disorder; excretion; ezrin; familial hypophosphatemia in rickets; feeding; gene product; genome mutation; hPTH(1-84); heavy metal Pb; heavy metal lead; hormonal regulation; hormone analog; hormone regulation; human PTH protein; hypercalcinuria; hypercalciuria; hypercalciuric; hypophosphatemia in rickets; improved; in vivo; inorganic phosphate; insight; intracellular skeleton; knock-down; member; membrane structure; mutant; novel; parathormone; parathyroid hormone, human; pathway; phosphoprotein p81; protein crosslink; pseudohypoparathyroidism (PHP, PHPT); pseudohypoparathyroidism syndrome; receptor; renal; renal proximal tubule; resistant; scaffold; scaffolding; social role; sodium phosphate; sodium-hydrogen exchanger regulatory factor; symporter; symporter (molecular); tool; urinary",PTH Regulation of Renal Phosphate Homeostasis,,11794,ZDK1,Special Emphasis Panel,,42,,399900
8017451,P01,DK,5,,,,,5P01DK011794-42,6852,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"POTTS, JOHN T;",1869644;,5P01DK011794,,,"Budgets; Hormonal; Human Resources; Individual; Manpower; Mechanics; Programs (PT); Programs [Publication Type]; Publications; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Role; Salaries; Scientific Publication; Structure; Wages; calcium metabolism; cost; personnel; programs; social role",Administrative Core,,11794,ZDK1,Special Emphasis Panel,,42,,163407
8017452,P01,DK,5,,,,,5P01DK011794-42,6853,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"KEUTMANN, HENRY T;",1872376;,5P01DK011794,,,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Agonist; Amino Acids; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Blood Coagulation Factor IV; Ca++ element; Calcitonin; Calcitonin(1-32); Calcitrin; Calcium; Chemicals; Chemistry; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Coagulation Factor IV; Consultations; Development; Documentation; Endocrine; Factor IV; Gases; HPLC; Hand; High Pressure Liquid Chromatography; Hormonal; Housing; Human Resources; Immunologic Deficiency Syndrome, Acquired; Individual; Intermediary Metabolism; Investigation; Investigators; Label; Laboratories; METBL; Manpower; Mass Spectrum; Mass Spectrum Analysis; Membrane Proteins; Membrane-Associated Proteins; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods; Modality; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); PTH (1-84); PTH protein, human; PTH-PTHrP Receptor; PTH-Related Peptide Receptor; PTH-Related Protein Receptor; PTHLP Receptor; PTHrP Receptor; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormone Receptor; Parathyroid Hormone Receptor 1; Parathyroid Hormone Receptor Type I; Parathyroid Hormone-Related Peptide Receptor; Parathyroid Hormones; Peptide Synthesis; Peptides; Performance; Phase; Photometry/Spectrum Analysis, Mass; Preparation; Procedures; Process; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; Proteins; Receptor, Parathyroid Hormone, Type 1; Receptor, Parathyroid Hormone-Like Peptide; Recombinants; Reproductive Endocrinology; Research; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Role; Science of Chemistry; Services; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Surface Proteins; Technology Transfer; Thyrocalcitonin; Time; United States National Institutes of Health; aminoacid; biosynthetic product; calcium metabolism; cost; cross-link; crosslink; experience; flexibility; gene product; hPTH(1-84); human PTH protein; in vivo; meetings; parathormone; parathyroid hormone, human; peptide analog; peptide chemical synthesis; personnel; programs; protein chemical synthesis; protein purification; social role; synthetic peptide",Peptide Core,,11794,ZDK1,Special Emphasis Panel,,42,,191472
8017453,P01,DK,5,,,,,5P01DK011794-42,6854,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BOUXSEIN, MARY L;",1872259;,5P01DK011794,,,"Al element; Aluminum; Animals; Area; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Biomechanics; Biomedical Research; Body Tissues; Bone; Bone Density; Bone Mineral Density; Bone and Bones; Bone structure of spine; Bones and Bone Tissue; Bovine Species; Brachydanio rerio; Cattle; Cell/Tissue, Immunohistochemistry; Common Rat Strains; Competence; Contralateral; Core Facility; Danio rerio; Data Collection; Densitometry; Development; Editorial; Editorial (PT); Editorial [Publication Type]; Elements; Endocrine; Equipment; Evaluation; Experimental Models; Experimental Models, Other; Funding; Gene Expression; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Genetics, in situ Hybridization; Growth; Hand; Histologic; Histologically; Histology; Hormonal; Human; Human Resources; Human, General; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Intervention; Intervention Strategies; Investigators; Journals; Kidney; Left; Load-Bearing; Loadbearing; Magazine; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Manpower; Manuscripts; Measurement; Measures; Mechanics; Methods and Techniques; Methods, Other; Mice; Minerals; Modeling; Models, Experimental; Molecular; Morphology; Murine; Mus; Musculoskeletal; Mutation; Nature; Neobalaenidae; Organ; Pattern; Phenotype; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publishing; Rat; Rattus; Reporting; Research Design; Research Personnel; Research Resources; Research Specimen; Researchers; Resolution; Resources; Rodent Model; Role; Savings; Services; Side; Skeleton; Specimen; Specimen Handling; Specimen Handlings; Specimen Processing; Structure-Activity Relationship; Study Type; System; System, LOINC Axis 4; Techniques; Technology; Testing; Time; Tissue Growth; Tissue Sample; Tissues; Training; Urinary System, Kidney; Vertebrae; Vertebral; Weight-Bearing; Weight-Bearing state; Weightbearing; Whales; Zebra Danio; Zebra Fish; Zebrafish; base; bone; bone geometry; bone imaging; bone scanning; bone strength; bovid; bovine; calcium metabolism; chemical structure function; cost; cow; density; editorial; experience; experiment; experimental research; experimental study; genome mutation; imaging; improved; in situ Hybridization Staining Method; in vivo; in vivo Model; interventional strategy; non-human primate; nonhuman primate; ontogeny; personnel; programs; protocol development; renal; research study; skeletal; skeletal imaging; social role; spine bone structure; structure function relationship; study design",Tissue Phenotyping Core,,11794,ZDK1,Special Emphasis Panel,,42,,234029
7754888,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,,NHLBI:2373599;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"CARDOSO, WELLINGTON V.;",1978581;,5P01HL047049,07/01/1998,01/31/2013,,DETERMINANTS OF CELL FATE AND DIFFERENTIATION IN THE DEVELOPING LUNG,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,2373599,
8018601,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,0007,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"CARDOSO, WELLINGTON V.;",1978581;,5P01HL047049,,,"ADAM10 protein; Adhesion Molecule; Antibodies; Appearance; Cancers; Cell Adhesion Molecules; Cell Communication; Cell Communication and Signaling; Cell Fate Control; Cell Fate Regulation; Cell Growth and Maintenance; Cell Interaction; Cell Maintenance; Cell Signaling; Cell-to-Cell Interaction; Cell/Tissue, Immunohistochemistry; Cells; Cleaved cell; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; DNA Sequence Rearrangement; DNA Synthesis Factor; Data; Development; Distal; Drosophila; Drosophila genus; ECGF; Embryo; Embryonic; Endoderm; Endoderm Cell; Endodermal Cell; Endothelial Cell Growth Factor; Epithelial; Epithelial Cells; Epithelium; Event; FGF; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Foregut; Fruit Fly, Drosophila; Genes; HBGF; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Intracellular Communication and Signaling; Label; Lateral; Lead; Lung; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Maps; Mediating; Mesenchymas; Mesenchyme; Mice; Modeling; Molecular; Morphogenesis; Mother Cells; Murine; Mus; Oils; Oncogenesis; Organ Culture; Organ Culture Techniques; Pathway interactions; Pattern; Pb element; Population; Primitive foregut structure; Primordium; Process; Progenitor Cells; Proteins; Pulmonary Body System; Pulmonary Organ System; Racial Segregation; Rearrangement; Reporter; Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stem cells; Structure; Testing; Time; Trachea; Trachea Proper; Tracts, Respiratory; Transgenic Organisms; Work; biological signal transduction; biological systems; cell adhesion protein; cleaved; fruit fly; gain of function; gamma secretase; gamma secretase complex; gene product; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; lung development; malignancy; mutant; neoplasm/cancer; notch; notch protein; notch receptors; pathway; progenitor; prospective; pulmonary; repair; repaired; respiratory; respiratory tract; response; segregation; social role; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; transgenic; tumorigenesis; windpipe",Mechanisms of Segregation of Respiratory Progenitors in the early lung,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339085
8018602,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,0008,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"LU, JINING ;",8151933;,5P01HL047049,,,"3' Untranslated Regions; 3'UTR; Acids; Affect; Assay; BMP-4; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Bronchial Tree; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Catenin, Beta-1; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lineage; Cell Lines, Strains; CellLine; Cells; Collaborations; Combining Site; Complex; DICER1; DICER1 Protein; DICER1 protein, human; DROSHA; Data; Dcr-1 Homolog; Defect; Dicer; Dicer Pathway; Dicer1, Dcr-1 homolog (Drosophila) protein, human; Distal; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 3.1.26.-; Embryo; Embryonic; Endoribonuclease Dicer; Epithelial; Epithelial Cells; Epithelium; Expression Profiling; Expression Signature; FGF-10; FGF10; Family member; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Generations; Genes; Genetic; Genetic Transcription; Genetics, in situ Hybridization; Goals; HERNA; HERNA protein, human; Helicase with RNase Motif; Helicase-MOI; Homolog of Drosophila Dicer; Hour; Human; Human, General; Immunologic, Luciferase; In Situ Hybridization; K12H4.8-Like; KGF-2 protein; KIAA0928; Keratinocyte Growth Factor 2; Knowledge; Laboratories; Luciferases; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Mice, Mutant Strains; Mice, Transgenic; Micro RNA; MicroRNAs; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Morphogenesis; Mother Cells; Murine; Mus; Mutant Strains Mice; Mutate; Nuclear RNase III Drosha; Nucleases, RNA; Nucleotides; Oligo; Oligonucleotides; Organism; PRO2286; Pathway interactions; Pattern; Play; Population; Principal Investigator; Process; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pulmonary Surfactant Protein C; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactant-Associated Protein SP-C; RN3; RNA Expression; RNA, Messenger; RNASE3L; RNase; RNase D; RNase III; RNase O; Reactive Site; Reporter; Respiratory System, Lung; Ribonuclease D; Ribonuclease Family Protein; Ribonuclease III; Ribonucleases; Role; SP-C peptide; SP-C protein; Signal Pathway; Signaling Molecule; Sorting - Cell Movement; Stem cells; Structure; Surfactant Polypeptide SP-C; Targetings, Gene; Testing; Tet; Tetanus Helper Peptide; Time; Transcription; Transcription, Genetic; Transgenic Mice; Translations; Trees; UTRs; Untranslated Regions; beta catenin; bone morphogenetic gene product-4; bone morphogenetic protein 4; cultured cell line; design; designing; fibroblast growth factor 10; gene product; human DICER1 protein; in situ Hybridization Staining Method; in vivo; insight; laser capture microdissection; living system; lung development; mRNA; miRNA; molecuar profile; molecular signature; mouse mutant; mutant; novel; p241; pathway; pri-miRNA; progenitor; programs; pulmonary; repifermin; social role; sorting",Micro RNA Pathway in proximal-distal differentiation during mouse lung developmen,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339085
8018603,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,0009,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"KOTTON, DARRELL N.;",6410558;,5P01HL047049,,,"Address; Anaplastic; Animal Model; Animal Models and Related Studies; Basic Fibroblast Growth Factor Gene; Blood Serum; Body Tissues; Boston; Brachyury; Brachyury protein; C Cell; Cardiac; Cell Communication and Signaling; Cell Culture System; Cell Signaling; Cell model; Cells; Cellular model; City of Boston; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collaborations; Complementary DNA; Complex; DNA Methylation; DNA Synthesis Factor; DNA, Complementary; Data; Derivation; Derivation procedure; Development; ECGF; ES Cell Line; ES cell; Embryo Development; Embryogenesis; Embryonic Development; Embryonic Stem Cell Line; Endoderm; Endoderm Cell; Endodermal Cell; Endothelial Cell Growth Factor; Engineering; Engineerings; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial; Epithelial Cells; Event; FGF; FGF-R; FGF10; FGF10 gene; FGF2; FGF2 gene; FGFB; FGFR; Family member; Fibroblast Growth Factor; Fibroblast Growth Factor 2 Gene; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Fibroblast Growth Regulatory Factor; Foregut; Foxes; Gastrointestinal Tract, Pancreas; Gene Expression; Genes; Genetic; Goals; HBGF; Head and Neck, Thyroid; Human; Human, General; In Vitro; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Keratinocyte Growth Factor 2 Gene; Liver; Lung; Lung Parenchyma; Lung Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Mesoderm; Method LOINC Axis 6; Methodology; Mice; Modeling; Mother Cells; Multipotent Stem Cells; Murine; Mus; P01 Mechanism; P01 Program; Pancreas; Pancreatic; Parafollicular Cell; Pattern; Polycomb; Primitive Streaks; Primitive foregut structure; Principal Investigator; Progenitor Cells; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pulmonary Surfactant Protein C; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactant-Associated Protein SP-C; Receptors, FGF; Reporter; Research Personnel; Research Program Projects; Researchers; Respiratory System, Lung; Role; SP-C peptide; SP-C protein; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Specific qualifier value; Specified; Staging; Stem cells; Streaks, Primitive; Structure of parenchyma of lung; Structure of thyroid parafollicular cell; Surfactant Polypeptide SP-C; System; System, LOINC Axis 4; T Brachyury protein; Testing; Thyroid; Thyroid Gland; Tissues; To specify; Transfection; Undifferentiated; Universities; biological signal transduction; body system, hepatic; bowel; cDNA; cell type; chromatin remodeling; design; designing; embryonic stem cell; gene product; genetic manipulation; in vivo; in vivo Model; lung development; model organism; mouse model; multipotent progenitor; novel; organ system, hepatic; progenitor; programs; pulmonary; recombinase; social role; stem cell biology; stem cell of embryonic origin; tool",Embryonic Stem Cell Modeling of Lung Lineage Specification,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339085
8018604,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,0010,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"RAMIREZ, MARIA ISABEL;",8001941;,5P01HL047049,,,"Activation, Gene; Anaplastic; Antibodies; Antimorphic mutation; Assay; BEK; BFR-1; BRM; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Breeding; CDR; CHIP assay; Cell Differentiation; Cell Differentiation process; Cell Lineage; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Commit; Cytidine, 2'-deoxy-; Cytosine Deoxyribonucleoside; Cytosine Deoxyriboside; DNA; DNA Binding; DNA Binding Interaction; DNA Methylation; DNA Modification Methylases; DNA Modification Methyltransferases; DNA amplification; DNA-Dependent RNA Polymerase II; DNA-Methyltransferases; Deoxycytidine; Deoxyribonucleic Acid; Development; Dnmt; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.1.1.113; ENX-1; ES cell; EZH1; EZH2; EZH2 gene; Embryo; Embryonic; Endoderm; Enhancer of Zeste 2; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelium; Evaluation; FGFR2; FGFR2 gene; Fibroblast Growth Factor Receptor 2 Gene; Foregut; Gene Action Regulation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Genomics; Goals; Histones; In Vitro; KGFR Gene; KSAM-1; Keratinocyte Growth Factor Receptor Gene; Knowledge; Lentiviral Vector; Lentivirus Vector; Link; Liver; Lung; MGC9169; Mammals, Mice; Mesenchymas; Mesenchyme; Messenger RNA; Methylation; Mice; Microarray Analysis; Microarray-Based Analysis; Modification; Modification Methylases; Molecular Interaction; Murine; Mus; Organ; Organogenesis; Pattern; Play; Polycomb; Primitive foregut structure; Primordium; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Proteins; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA, Messenger; Regulation; Regulatory Protein; Respiratory System, Lung; Role; Site-Specific DNA-methyltransferase; System; System, LOINC Axis 4; TK14; Targetings, Gene; Testing; Tissues; Transcription; Transcription, Genetic; Undifferentiated; base; bisulfite; body system, hepatic; brahma; brahma gene product; brahma protein; brm gene product; chromatin immunoprecipitation; chromatin modification; chromatin remodeling; embryonic stem cell; enzyme activity; gene product; genetic regulatory protein; genome-wide; histone modification; hydrogen sulfite; hydrosulfite; in vivo; lung development; mRNA; microarray technology; organ system, hepatic; programs; protein complex; protein expression; pulmonary; recombinase; regulatory gene product; shRNA; short hairpin RNA; small hairpin RNA; social role; stem; stem cell of embryonic origin",Chromatin modifications and DNA methylation during early lung development,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339086
8018605,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,9004,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"FINE, ALAN FINE;",1965990;,5P01HL047049,,,"Budgets; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cell/Tissue, Immunohistochemistry; Cells; Computer Programs; Computer software; Computers; Consultations; Cytofluorometry, Flow; Cytometry; DISSEC; Devices; Dissection; Educational process of instructing; Electromagnetic, Laser; Ensure; Equipment; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence Microscopy; Gene Expression; Genetics, in situ Hybridization; Glass; Goals; Hand; Histological Technics; Histological Techniques; History; Human Resources; IHC; Image; Image Analyses; Image Analysis; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ; In Situ Hybridization; Individual; Investigators; Lasers; Lung; Maintenance; Maintenances; Manpower; Methods; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Microscope; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Moab, Clinical Treatment; Monoclonal Antibodies; Paraffin; Paraffin waxes and Hydrocarbon waxes; Performance; Phase; Postdoc; Postdoctoral Fellow; Procedures; Protocol; Protocols documentation; ROC Analysis; Radiation, Laser; Reagent; Recording of previous events; Research Associate; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Slide; Software; Speed; Speed (motion); Staining method; Stainings; Stains; Teaching; Technics, Histologic; Techniques; Techniques, Histologic; Training; base; cell sorting; computer program/software; data mining; datamining; design; designing; experience; flow cytophotometry; image evaluation; imaging; in situ Hybridization Staining Method; instrument; interest; lung development; personnel; post-doc; post-doctoral; pulmonary; success",Microscopy-Image Analysis Core,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339086
8018606,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,9005,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"RAMIREZ, MARIA ISABEL;",8001941;,5P01HL047049,,,"Animals; Archives; Breeding; Cells; DNA purification; Ear; Ear structure; Equipment; Genetic; Genomics; Genotype; Gestation; Investigators; Knock-in; Knock-in Mouse; Knockout Mice; Laboratories; Link; Lung; Mammals, Mice; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Null Mouse; Pregnancy; Programs (PT); Programs [Publication Type]; Research Personnel; Researchers; Respiratory System, Lung; System; System, LOINC Axis 4; Techniques; Time; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Transgenes; Transgenic Organisms; Weaning; animal breeding; experience; experiment; experimental research; experimental study; programs; pulmonary; pup; research study; transgenic",Mouse Genetics Core,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339086
8018607,P01,HL,5,,02/01/2010,01/31/2011,,5P01HL047049-18,9007,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"CARDOSO, WELLINGTON V.;",1978581;,5P01HL047049,,,"Care, Health; Cells; Data; Documentation; Grant; Healthcare; Human Resources; IACUC; Institutional Animal Care and Use Committee; Insurance; Investigators; Isotopes; Lung; Manpower; Medical center; Molecular Biology, Recombinant DNA; P01 Mechanism; P01 Program; Personnel Management; Play; Program Project Grant; Program Research Project Grants; Progress Reports; Protocol; Protocols documentation; Recombinant DNA; Reporting; Reports, Progress; Research; Research Personnel; Research Program Projects; Researchers; Respiratory System, Lung; SCHED; Salaries and Fringe Benefits; Schedule; Services; Travel; Update; Visit; Writing; material transfer agreement; meetings; personnel; pulmonary; rDNA",Administrative Core,,47049,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,18,,339086
7752820,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,,NHLBI:2427759;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,VETERINARY SCIENCES,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"LAUGHLIN, M HAROLD;",1866974;,5P01HL052490,05/05/1995,12/31/2010,,Vascular Biology: Exercise Training and Vascular Disease,,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,2427759,
8011464,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,0003,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"LAUGHLIN, M HAROLD;",1866974;,5P01HL052490,,,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; 1-((4-((dimethylphenyl)azo)dimethylphenyl)azo)-2- naphthalenol; Abbreviations; Acids; Active Oxygen; Adenosine 5'-(trihydrogen diphosphate); Adenosine 5'-Pyrophosphate; Adenosine Diphosphate; Adenosine Pyrophosphate; Adipocytes; Adipose Cell; Adipose tissue; Animals; Anterior Descending Coronary Artery; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-atherogenic; Anti-inflammatory; Antiatherogenic; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Aorta; Arachidonic Acid Cyclooxygenase; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Arteries; Arterioles; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Biochemical; Biology; Blood Vessels; Blood flow; Bovine Species; Brachial Artery; Bradykinin; CAV1; CD106; CD106 Antigens; CNOS; COX; COX-1; COX-1 protein; COX-2 protein; COX-3 enzyme; COX1; COX2; COX2 enzyme; COX3; CXCL12 protein; Cardiac artery; Cattle; Caveolae Protein, 22kD; Caveolin 1, Caveolae Protein, 22kD; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Chemokine (C-X-C Motif) Ligand 12; Chest; Cholest-5-en-3-ol (3beta)-; Cholesterol; Constitutive NOS; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary artery; Coronary heart disease; Cyclo-Oxygenase; Cyclo-Oxygenase-1; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 3; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Development; Diet; Dose; Dysfunction; ECM; ECNOS; ENOS; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Enzyme Gene; Enzyme Tests; Enzymes; Erythrocuprein; Exercise; Exercise, Physical; Exhibits; Extracellular Matrix; Family suidae; Fat Cells; Fats; Fatty Acid Cyclo-Oxygenase; Fatty Acid Cyclooxygenase; Fatty Tissue; Fatty acid glycerol esters; Foam Cells; Foundations; Functional disorder; Funding; Gene Expression; Gene Transcription; Genes; Genetic Transcription; HSP-90; HSP90; Heart artery; Heat-Shock Proteins 90; Hemocuprein; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Hydroperoxide Cyclase; INCAM-110; Inducible Cell Adhesion Molecule 110; Intracellular Communication and Signaling; Investigators; Isoenzymes; Isozymes; Knock-out; Knockout; L-NAME; Left; Lesion; Lipocytes; Maintenance; Maintenances; Mature Lipocyte; Mature fat cell; Mechanics; Mediating; Messenger RNA; Methods and Techniques; Methods, Other; Modeling; Modification; Molecular; Molecular Interaction; Muscle, Smooth, Vascular; N omega-Nitro-L-arginine Methyl Ester; N(G)-Nitro-L-arginine Methyl Ester; N(G)-Nitroarginine Methyl Ester; NG-Nitro-L-Arginine Methyl Ester; NG-Nitroarginine Methyl Ester; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Na element; Names; Nitric Oxide Synthase 3; Oxygen Radicals; P450; PGH Synthase; PGH Synthase 1; PGH Synthase 2; PGH2 Synthetase; PGHS-1; PGHS-2; PGHS2; PHS II; PHS1; PTGS1; PTGS2; Phenotype; Physiopathology; Pigs; Pre-B Cell Growth Stimulating Factor; Pressure; Pressure- physical agent; Prevention; Pro-Oxidants; Procedures; Production; Property; Property, LOINC Axis 2; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin G/H Synthase 1; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H Synthase; Prostaglandin H2 Synthase; Prostaglandin H2 Synthase 1; Prostaglandin H2 Synthase 2; Prostaglandin H2 Synthetase; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin-Endoperoxide Synthase 2; Proteins; Protocol; Protocols documentation; RNA Expression; RNA, Messenger; Reactive Oxygen Species; Receptor Protein; Research; Research Personnel; Researchers; Role; SDF-1; SDF-1alpha; SOD; Sdf1 protein; Sedentary Exercise; Signal Transduction; Signal Transduction Systems; Signaling; Sodium; Solid; Staging; Staining method; Stainings; Stains; Stress; Stretching; Stromal Cell-Derived Factor 1; Structure of arteriole; Structure of brachial artery; Suidae; Superoxide Anion; Superoxide Dismutase; Superoxide Radical; Superoxide[{..}]superoxide oxidoreductase; Superoxides; Swine; System; System, LOINC Axis 4; Techniques; Testing; Thorace; Thoracic; Thorax; Thromboxanes; Training; Transcription; Transcription, Genetic; Trees; VCAM; VCAM-1; VIP21; VIP21 protein; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vasomotor; Very Light Activity; Very Light Exercise; acetylated LDL receptor; adipose; advanced disease; anti-oxidant; arteriole; atherogenesis; atheromatosis; atheroprotective; atherosclerotic vascular disease; base; biological signal transduction; blood vessel disorder; bovid; bovine; brachial artery; catalase; caveolin; caveolin 1; coronary disorder; cow; cyclo-oxygenase I; cyclo-oxygenase II; cyclooxygenase 1; cyclooxygenase 2; cyclooxygenase-3; cytocuprein; design; designing; diet and exercise; eNOS enzyme; endothelial constitutive nitric oxide synthase; enzyme activity; experiment; experimental research; experimental study; feeding; gene product; hIRH; hsp90 Family; human NOS3 protein; improved; kallidin 9; kallidin I; mRNA; mRNA Expression; oil red O; pathophysiology; porcine; pressure; prevent; preventing; prostaglandin H synthase-1; prostaglandin H synthase-2; receptor; receptor, acetyl-LDL; relaxing factor; research study; restoration; scavenger receptor; sedentary; shear stress; social role; stromal cell-derived factor-1alpha; suid; vascular; vesicular integral membrane protein 21 kDa; white adipose tissue; yellow adipose tissue","Exercise Training: Endothelial Phenotype, Coronary Disease",,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,438037
8011465,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,0006,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"BOWLES, DOUGLAS K;",1877388;,5P01HL052490,,,"2ar peptide; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; ATF; Abbreviations; Activator Protein-1; Antigens, Differentiation; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Automobile Driving; Biology; Blood Coagulation Factor IV; Blood Vessels; CCL2; CCL2 gene; CCND1 Protein; CREB; CREB1; CREB1 gene; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Channels, L-Type; Cells; Cholest-5-en-3-ol (3beta)-; Cholesterol; Coagulation Factor IV; Coronary; Coronary Angiography; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cyclin D1; Cytophotometry; Dependence; Development; Diet; Differentiation Antigens; Differentiation Markers; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drivings, Automobile; EDN1; EGF; EGF gene; ET-1; ET-1 (Endothelin-1); Electrophysiology; Electrophysiology (science); Endogenous Nitrate Vasodilator; Endothelin Type 1; Endothelin-1; Endothelium-Derived Relaxing Factor; Enhancer-Binding Protein AP1; Equilibrium; Eta-1 protein; Eta-1-Op protein; Exercise; Exercise, Physical; Factor IV; Family suidae; Fats; Fatty acid glycerol esters; G1/S-Specific Cyclin D1; GDCF-2; GDCF-2 HC11; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genes, p53; HC11; Immunoblotting; In Vitro; Injury; Ion Channel; Ion Channels, Calcium; Ion Channels, Potassium; Ionic Channels; K channel; L-Type Calcium Channels; L-Type VDCC; L-Type Voltage-Dependent Calcium Channels; Lesion; Link; Long-Lasting Calcium Channels; MCAF; MCP-1; MCP1; MGC9434; MTGN; MYH11; MYH11 protein, human; Maintenance; Maintenances; Marker Antigens; Markers, Differentation; Measures; Mediating; Membrane Channels; Membrane Potentials; Messenger RNA; Methods and Techniques; Methods, Other; Microfluorometry; Mitogens; Modeling; Molecular; Mononitrogen Monoxide; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Heavy Chain, Smooth Muscle Isoform; Myosin, Heavy Polypeptide 11, Smooth Muscle; Neurophysiology / Electrophysiology; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear Translocation; P53; PDGF-BB; PRAD1 Protein; Pathway interactions; Phenotype; Phosphorylation; Pigs; Potassium Channel; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proliferation Marker; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-1; RNA, Messenger; RNA, Small Interfering; RT-PCR; RTPCR; Receptors, Calcium Channel Blocker; Regulation; Relative; Relative (related person); Reporter; Research; Resistance; Resting Potentials; Reverse Transcriptase Polymerase Chain Reaction; Role; SCYA2; SMC-CF; SMHC; SMMHC; Secondary Prevention; Small Interfering RNA; Smooth Muscle Myosin Heavy Chain 11; Smooth muscle (tissue); Streaks, Arterial Fatty; Suidae; Swine; TP53; TP53 gene; TRP53; Techniques; Testing; Training; Transcription Factor AP-1; Transfection; Transmembrane Potentials; Tumor Protein p53 Gene; URG; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); VDCC; Vascular Diseases; Vascular Disorder; Voltage-Dependent Calcium Channels; activating transcription factor; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; balance; balance function; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; blood vessel disorder; bone sialoprotein 1; bone sialoprotein I; c-bcl-1 Proteins; cyclin D; driving; drug development; early T-lympocyte activation-1 protein; endothelial cell derived relaxing factor; gene product; human MYH11 protein; in vitro testing; in vivo; mRNA; novel; osteopontin; pathway; phosphoprotein I, 2aR; platelet-derived growth factor BB; porcine; prevent; preventing; programs; resistant; response; reverse transcriptase PCR; secreted phosphoprotein 1; siRNA; sialoprotein 1; social role; suid; transcription factor; vascular; voltage; vulnerable plaque",Ion Channel Regulation of Coronary Smooth Muscle Phenotype,,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,327467
8011466,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,0007,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"HAMILTON, MARC THOMAS;",1868099;,5P01HL052490,,,"Adipose tissue; Agonist; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-atherogenic; Anti-inflammatory; Antiatherogenic; Antiinflammatories; Antiinflammatory Agents; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biology; Blood Plasma; Blood Vessels; Body Tissues; Body Weight; CD106; CD106 Antigens; CD62E Antigens; CD62P Antigens; CNOS; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Adhesion Molecule E-Selectin; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell/Tissue, Immunohistochemistry; Chemicals; Cholest-5-en-3-ol (3beta)-; Cholesterol; Complex; Constitutive NOS; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; DAG lipase; Data; Diacylglycerol Lipase; Diet; Differential Gene Expression; Diglyceride Lipase; Dose; Dysfunction; E-Selectin; ECNOS; ELAM-1; ENOS; Endothelial Adhesion Molecule 1; Endothelial Cells; Endothelial Leukocyte Adhesion Molecule-1; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Ensure; Enzymes; Exercise; Exercise, Physical; Experimental Models; Experimental Models, Other; Exposure to; Family suidae; Fats; Fatty Tissue; Fatty acid glycerol esters; Functional disorder; GMP-140; Gene Expression; Gene Proteins; Genes; Health; Heparin-Clearing Factor; Hepatocyte Nitric Oxide Synthase; Hypercholesteremia; ICAM; IHC; INCAM-110; INOS; Immunoblotting; Immunohistochemistry; Immunohistochemistry Staining Method; Inducible Cell Adhesion Molecule 110; Inducible Nitric Oxide Synthase; Inflammatory; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; LDL Cholesterol; LDL Cholesterol Lipoproteins; LECAM-2; LECAM-3; LPL; Leukocyte Endothelial Cell Adhesion Molecule 2; Life Style; Lifestyle; Ligands; Link; Lipemia-Clearing Factor; Lipids; Lipolysis; Lipoproteins; Low Density Lipoprotein Cholesterol; METBL; Macrophage Nitric Oxide Synthase; Mammalia; Mammals; Mammals, General; Measurement; Measures; Mechanics; Mediating; Messenger RNA; Metabolic; Metabolic Processes; Metabolism; Microcirculation; Modeling; Models, Experimental; Molecular; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Muscle, Cardiac; Muscle, Heart; Muscle, Involuntary; Muscle, Skeletal; Muscle, Smooth; Muscle, Voluntary; Myocardium; NADPH Oxidase; NOS Type II; NOS Type III; NOS2; NOS2A; NOS2A protein, human; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide Synthase 2A; Nitric Oxide Synthase 3; Nuclear; Outcome; P-Selectin; PPAR; Pathway interactions; Perfusion; Peripheral; Peroxisome Proliferator-Activated Receptors; Phenotype; Physiologic; Physiological; Physiopathology; Pigs; Plasma; Platelet alpha-Granule Membrane Protein; Play; Post-Heparin Lipase; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postheparin Lipase; Postheparin Lipoprotein Lipase; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevention; Programs (PT); Programs [Publication Type]; Protein Gene Products; Proteins; Protocol; Protocols documentation; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Small Interfering; RNAi; Receptor Protein; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; Role; SOD-1 protein; SOD1 gene product; Sedentary Exercise; Sequence-Specific Posttranscriptional Gene Silencing; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Small Inducible Cytokine A2; Small Interfering RNA; Smooth muscle (tissue); Stimulus; Structure; Suidae; Swine; THBS1; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TSP; TSP-1; TSP1; Testing; Thrombospondin 1; Time; TimeLine; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Training; Triacylglycero-protein acylhydrolase; Triglyceride Metabolism; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vasodilatation; Vasodilation; Vasorelaxation; Very Light Activity; Very Light Exercise; Work; adipose; atheromatosis; atherosclerotic vascular disease; beta-Lipoprotein Cholesterol; biological signal transduction; blood vessel disorder; cardiac muscle; cell type; clearing factor lipase; cytokine; disease prevention; disorder prevention; eNOS enzyme; endothelial constitutive nitric oxide synthase; endothelial leukocyte adhesion molecule; experiment; experimental research; experimental study; feeding; gene product; heart muscle; hemodynamics; human NOS2A protein; human NOS3 protein; hypercholesterolemia; iNOS enzyme; improved; in vivo; in vivo Model; insight; intercellular cell adhesion molecule; lipoprotein lipase; mRNA; macrophage; model organism; nitric oxide synthase, Type II; novel; pathophysiology; pathway; porcine; programs; receptor; research study; response; sedentary; siRNA; social role; suid; superoxide dismutase 1; transcription factor; triacylglycerol protein acylhydrolase; tumor necrosis factor (unspecified); vascular; white adipose tissue; yellow adipose tissue",Lipoprotein Lipase Regulation Arterial Endothelium Exercise and Atherosclerosis,,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,298551
8011467,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,0008,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"TERJUNG, RONALD L;",6073059;,5P01HL052490,,,"Activities of Daily Living; Activities of everyday life; Acute; Animals; Arterial Obstruction; Arterial Occlusion; Artery Obstruction; Atherogenic Diet; Biology; Blood Vessels; Blood flow; Body Tissues; Bypass; Caliber; Charcot's syndrome; Clinical; Clinical Research; Clinical Study; Closure by Ligation; Common Rat Strains; Complex; Development; Diameter; Diet; Diet, Atherogenic; Diffuse; Distal; Dysfunction; Endothelium; Evaluation; Exercise; Exercise Tolerance; Exercise, Physical; Extremities; FLR; Failure (biologic function); Family suidae; Femoral Artery; Functional disorder; Hindlimb; Human; Human, General; Image; In Vitro; Intermittent Claudication; Investigators; Ischemia; Leg; Lesion; Ligation; Limb structure; Limbs; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rabbits; Mammals, Rats; Man (Taxonomy); Man, Modern; Mice; Miniature Swine; Minipigs; Morphology; Murine; Mus; Muscle; Muscle Tissue; Non-Trunk; Obstruction; Oryctolagus cuniculus; Patients; Perfusion; Peripheral; Physical activity; Physiopathology; Pigs; Pressure; Pressure- physical agent; Programs (PT); Programs [Publication Type]; Rabbit, Domestic; Rabbits; Radial; Rat; Rattus; Research Personnel; Researchers; Shunt; Shunt Device; Stimulus; Stress; Structure of femoral artery; Suidae; Swine; Swine, Miniature; Testing; Tissues; Training; Vascular Diseases; Vascular Disorder; Venous; Walking; artery occlusion; blood vessel disorder; claudication; daily living functionality; failure; feeding; femoral artery; functional ability; functional capacity; imaging; improved; improved functioning; indexing; instrument; mini pig; pathophysiology; porcine; preclinical study; precursor cell; pressure; programs; response; shear stress; shunts; suid; vascular; vessel regression",Factors Controlling Peripheral Collateral Vessel Development in a Large Mammal,,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,374831
8011468,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,9001,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"TURK, JAMES R;",2074673;,5P01HL052490,,,"Animal Care Assistants; Animal Care Technicians; Animal Technicians; Animals; Autopsy; Biochemical; Biology; Blood; Blood Plasma; Blood Vessels; CNOS; Cardiovascular Diseases; Cholest-5-en-3-ol (3beta)-; Cholesterol; Constitutive NOS; Diagnostic; Diet; ECNOS; ENOS; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Evaluation; Exercise; Exercise, Physical; Family suidae; Fats; Fatty acid glycerol esters; HDL Cholesterol; Health; High Density Lipoprotein Cholesterol; Human Resources; Knock-out; Knockout; LDL; Laboratories; Lipoproteins, HDL Cholesterol; Lipoproteins, LDL; Low-Density Lipoproteins; Manpower; Medical; Medical Students; Missouri; Monitor; Muscle, Skeletal; Muscle, Voluntary; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide Synthase 3; Pathologic; Pathology; Pigs; Plasma; Procedures; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Sampling; Serum, Plasma; Skeletal Muscle Tissue; Skeletal muscle structure; Students, Medical; Suidae; Supervision; Swine; Training; Transgenic Organisms; Triacylglycerol; Triglycerides; Universities; Vascular Diseases; Vascular Disorder; Veterinary Assistants; Veterinary Nurses; Veterinary Technicians; abstracting; alpha-Lipoprotein Cholesterol; animal care; animal resource; beta-Lipoproteins; blood vessel disorder; cardiovascular disorder; diet and exercise; eNOS enzyme; endothelial constitutive nitric oxide synthase; feeding; human NOS3 protein; male; necropsy; overexpression; performance tests; personnel; porcine; postmortem; suid; transgenic; vascular","Animal Care, Training, and Pathology",,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,695972
8011469,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL052490-15,9002,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"PRICE, ELMER M;",8489579;,5P01HL052490,,,"Address; Animal Feed; Animals; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Aorta; Arteries; Arterioles; Arts; Biochemical; Biochemistry; Biology; Biosynthetic Proteins; Blood Cells; Blood Circulation; Blood Vessels; Bloodstream; Body Tissues; Caliber; Cardiac artery; Cell Communication and Signaling; Cell Fractionation; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cells; Chemistry, Biological; Cholest-5-en-3-ol (3beta)-; Cholesterol; Circulation; Cloning; Co-Immunoprecipitations; Core Facility; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary artery; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; DNA Molecular Biology; Data; Development; Diameter; Diet; Dysfunction; Endothelial Cells; Endothelium; Ensure; Environment; Equipment; Exercise; Exercise, Physical; Family suidae; Fats; Fatty acid glycerol esters; Functional disorder; Funding; Gene Expression; Genes; Genetics, in situ Hybridization; Goals; Hand; Heart artery; Hour; Human; Human Resources; Human, General; Immune Precipitation; Immunoblotting; Immunoprecipitation; In Situ; In Situ Hybridization; In Vitro; Individual; Intracellular Communication and Signaling; Investigators; Isoforms; Laboratories; Libraries; Mammals, Rodents; Man (Taxonomy); Man, Modern; Manpower; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Biology; Mother Cells; Muscle, Smooth, Vascular; P450; PBMC; Peripheral; Peripheral Blood Cell; Peripheral Blood Mononuclear Cell; Phenotype; Physiologic; Physiological; Physiopathology; Pigs; Plasmids; Play; Preparation; Principal Investigator; Procedures; Productivity; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Proteins; Qualifying; RNA, Messenger; RNA, Small Interfering; RT-PCR; RTPCR; Reagent; Recombinant Proteins; Relative; Relative (related person); Research Personnel; Research Resources; Researchers; Resistance; Resources; Reverse Transcriptase Polymerase Chain Reaction; Rodent; Rodentia; Rodentias; Role; Sampling; Sedentary Exercise; Services; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Stem cells; Structure of arteriole; Suidae; Swine; Techniques; Time; Tissues; Training; Transgenic Organisms; Vascular Diseases; Vascular Disorder; Very Light Activity; Very Light Exercise; Viral; Virion; Virus Particle; Work; animal food; antibody biosynthesis; arteriole; base; biological signal transduction; blood vessel disorder; cell sorting; cell transduction; cell type; cellular transduction; design; designing; experiment; experimental research; experimental study; gene product; immunoglobulin biosynthesis; in situ Hybridization Staining Method; interest; knock-down; laser capture microdissection; mRNA; mRNA Expression; member; novel; pathophysiology; personnel; porcine; programs; protein expression; protein protein interaction; research study; resistant; response; reverse transcriptase PCR; siRNA; social role; subcellular fractionation; suid; tool; transduced cells; transgenic; vascular; vector",Vascular Biochemistry and Molecular Biology,,52490,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,15,,292901
7754087,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,,NHLBI:1712866;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HARRISON, DAVID G;",1866960;,5P01HL058000,05/01/1999,12/31/2013,,"Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease",,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,1712866,
8016641,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5165,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HARRISON, DAVID G;",1866960;,5P01HL058000,,,"ANG-(1-8)Octapeptide; Active Oxygen; Address; Adipocytes; Adipose Cell; Adipose tissue; Adoptive Transfer; Adventitia; Affect; AngII; Angiotensin AT1 Receptor; Angiotensin II; Angiotensin II Type 1 Receptor; Angiotensin-(1-8) Octapeptide; Angiotensins; Autologous; B blood cells; B-Cells; B-Lymphocytes; Blood Pressure; Blood Pressure, High; Blood Vessels; Body Tissues; Brain; Brain Stem; Brainstem; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-C CKR-1 Gene; C-C CKR-5 Gene; C-C Chemokine Receptor Type 1 Gene; C-C Chemokine Receptor Type 5 Gene; CC-CKR-1 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCL5; CCR-1 Gene; CCR-5 Gene; CCR1; CCR1 gene; CCR5; CCR5 gene; CD195 Antigen Gene; CHEMR13 Gene; CKR-1 Gene; CKR-5 Gene; CKR5 Gene; CMKBR1 Gene; CMKBR5 Gene; CMKR1 Gene; Cardiovascular Diseases; Causality; Cells; Central Nervous System; Chemokine (C-C Motif) Ligand 5; Chemokine (C-C) Receptor 5 Gene; Chronic; Collaborations; D17S136E; DNA Alteration; DNA mutation; Data; Development; Diffusion; Disease; Disorder; Distal; Dose; Dysfunction; Employee Strikes; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium; Endothelium, Vascular; Endothelium-Derived Relaxing Factor; Enzymes; Etiology; Exhibits; Experimental Models; Experimental Models, Other; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Fore-Brain; Forebrain; Functional disorder; Funding; Gene Alteration; Gene Mutation; Genetic mutation; Goals; Grafting, Kidney; HIV-1 Fusion Co-Receptor Gene; HM145 Gene; Home; Home environment; Homing; Human; Human, General; Hydrogen Oxide; Hypertension; INFLM; Implant; Infiltration; Inflammation; Inflammatory Response; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Interruption; Investigators; Kidney; Kidney Transplantation; Kidney Transplants; LD78 Receptor Gene; Laboratories; Lesion; Ligands; Link; Lipocytes; Lymphatic Tissue; Lymphoid Tissue; MGC17164; MIP-1Alpha-R Gene; MIP1aR Gene; Macrophage Inflammatory Protein-1 Alpha Receptor Gene; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Measurement; Mediating; Methods; Mice; Modeling; Models, Experimental; Mononitrogen Monoxide; Murine; Mus; Muscle, Smooth, Vascular; NADPH Oxidase; Na element; Nephrons; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nox enzyme; Organ; Oxidases; Oxygen Radicals; P01 Mechanism; P01 Program; Peripheral Resistance; Physiopathology; Play; Pro-Oxidants; Process; Production; Program Project Grant; Program Research Project Grants; Programs (PT); Programs [Publication Type]; Prosencephalon; RANTES; RANTES Protein, T-Cell; RANTES Receptor Gene; RANTES-R Gene; Reactive Oxygen Species; Receptor Protein; Receptor, Angiotensin, Type 1; Relative; Relative (related person); Renal Transplantation; Renal Transplants; Research; Research Personnel; Research Program Projects; Researchers; Resistance, Total Peripheral; Role; SCID; SCID Mice; SCYA5; SIS delta; SIS-delta; SISd; Sequence Alteration; Services; Severe Combined Immunodeficient Mice; Site; Small Inducible Cytokine A5; Sodium; Sodium Chloride; Sodium chloride (NaCl); Source; Strikes; Strikes, Employee; T-Cell Specific Protein p288; T-Cells; T-Lymphocyte; TCP228; Technology; Third Cerebral Ventricle; Third Ventricle; Third Ventricle of Brain; Third ventricle structure; Thymus-Dependent Lymphocytes; Tissues; Tunica Adventitia; Urinary System, Kidney; Uriniferous Tube; Vascular Endothelium; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Resistance, Systemic; Vascular constriction (function); Vasoconstriction; Vasodilating Agent; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Visit; Water; adipose; base; cardiovascular disorder; cell type; chemokine receptor; constriction; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; human tissue; hyperpiesia; hyperpiesis; hypertensive disease; neural; neuronal; oxidant stress; pathophysiology; prevent; preventing; professor; programs; receptor; relating to nervous system; renal; research study; response; salt; severe combined immune deficiency; social role; thymus derived lymphocyte; vascular; vascular inflammation; white adipose tissue; yellow adipose tissue",The role of the T Cell in the Genesis of Hypertension,,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,445481
8016642,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5166,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"WEYAND, CORNELIA M;",1881774;,5P01HL058000,,,"92-kDa Gelatinase; 92-kDa Type IV Collagenase; ANG-(1-8)Octapeptide; APC; APO2L; ATGN; Active Oxygen; Address; Adoptive Transfer; Almirall Brand of Nimodipine; Amino Acids; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensins; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigen Processing; Antigen Processings; Antigen-Presenting Cells; Antigens; Antiinflammatories; Antiinflammatory Agents; Apo-2L; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biology; Blood Vessels; Blood flow; Blood monocyte; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTLA-8; CTLA8; Cardiac infarction; Cardiovascular Diseases; Carotid Artery Plaque; Carotid Artery Plaques; Carotid Artery Ulcerating Plaque; Catabolism; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chimera; Chimera organism; Chronic; Closure by Ligation; Co-culture; Cocultivation; Coculture; Coculture Techniques; Commit; Coronary; Cues; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; DR5; Data; Death; Dendritic Cells; Dendritic cell activation; Development; Dioxygenases; Doctor of Medicine; Dysfunction; EC 2.7; Edodekin Alfa; Effector Cell; Endothelial Cells; Environment; Enzymes; Event; Family; Functional disorder; Gelatinase B; Generations; Goals; Homologous Chemotactic Cytokines; Human; Human, General; IDOase; IL-1 alpha; IL-1-a; IL-12; IL-17; IL-17A; IL-1A; IL-1alpha; IL1-Alpha; IL12; IL17; IL17 Protein; IL17A; IL1A; IL1A Protein; IL1F1; INFLM; Immune; Immune response; Immune system; Immunologic Accessory Cells; Immunologic, Immunochemical; Immunologics; Immunomodulation; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunotherapeutic agent; Implant; Indoleamine 2,3-Dioxygenase; Indoleamine-Oxygen 2,3-Oxidoreductase (Decyclizing); Infection; Inflammation; Inflammatory; Injury; Instruction; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin 1alpha; Interleukin-1 alpha; Interleukin-12; Interleukin-17; Interphase; Intracellular Communication and Signaling; Investigators; KILLER; KILLER/DR5; Killings; Kinases; L-Tryptophan; L-Tryptophan[{..}]oxygen 2,3-oxidoreductase (decyclizing); Leiomyocyte; Lesion; Levotryptophan; Ligands; Ligation; Lymphocyte; Lymphocytic; Lytotoxicity; M.D.; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Man (Taxonomy); Man, Modern; Marrow monocyte; Matrix Metalloproteinase-9; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metallopeptidases; Metalloproteases; Metalloproteinases; Modeling; Modus; Molecular; Monocytes / Macrophages / APC; Myelogenous; Myeloid; Myocardial Infarct; Myocardial Infarction; Myocytes, Smooth Muscle; NADPH Oxidase; NKSF; Natural Killer Cell Stimulatory Factor; Natural immunosuppression; Organ Culture; Organ Culture Techniques; Oxidative Stress; Oxidative Stress Induced Gene Expression Via Nrf2; Oxidative Stress Pathway; Oxygen Radicals; Palsy; Paralysed; Pathway interactions; Patients; Pattern; Pattern recognition receptor; Peptides; Phagocytosis; Phase; Phosphotransferases; Physiopathology; Plaques, Carotid Artery; Plegia; Population; Position; Positioning Attribute; Predisposition; Preinterleukin 1 Alpha; Pro-Oxidants; Process; Production; Property; Property, LOINC Axis 2; Reactive Oxygen Species; Receptor Protein; Regulatory T-Lymphocyte; Research Personnel; Researchers; Resource Sharing; Role; Rupture; SCID; SCID Mice; SIS cytokines; Sentinel; Severe Combined Immunodeficient Mice; Shapes; Shoulder; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Starvation; Streaks, Arterial Fatty; Stress; Stroke; Subcellular Process; Supplementation; Suppressor Cells; Suppressor-Effector T-Lymphocytes; Susceptibility; Synapses; Synaptic; System; System, LOINC Axis 4; T Suppressor Cell; T-Cell Activation; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Suppressor-Effector; T4 Cells; T4 Lymphocytes; TL2; TLR protein; TLR4; TLR4 gene; TNFRSF10B; TNFRSF10B gene; TNFSF10; TNFSF10 gene; TOLL; TRAIL; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissues; Toll-like receptors; Transphosphorylases; Tryptophan; Tryptophan 2,3 Dioxygenase; Tryptophan Metabolism; Tryptophan Metabolism Pathway; Tryptophan Oxygenase; Tryptophan Pyrrolase; Type V Collagenase; Ulcerating Plaque, Carotid Artery; Ulcers, Carotid; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; Veiled Cells; Viral; Wound Healing; Wound Repair; ZTNFR9; abstracting; accessory cell; acute coronary syndrome; aminoacid; antigen processing; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; biological signal transduction; body system, allergic/immunologic; brain attack; cardiac infarct; cardiovascular disorder; carotid plaque; cell damage; cell injury; cell type; cerebral vascular accident; chemoattractant cytokine; chemokine; coronary attack; coronary infarct; coronary infarction; cytokine; cytotoxic; cytotoxicity; design; designing; eroded vascular plaques; experiment; experimental research; experimental study; hToll; heart attack; heart infarct; heart infarction; helper T cell; host response; immune modulation; immunogen; immunologic preparation; immunologic reactivity control; immunoregulation; immunoresponse; immunosuppression; immunosuppressive; immunotherapeutics; in vivo; indoleamine; instructor; lymph cell; macrophage; metalloproteinase (general); microbial; monocyte; necrocytosis; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; novel therapeutics; organ system, allergic/immunologic; oxidant stress; paralysis; paralytic; pathogen; pathophysiology; pathway; prevent; preventing; receptor; receptor binding; receptor expression; research study; sensor; severe combined immune deficiency; social role; stroke; success; suppressor T lymphocyte; thymus derived lymphocyte; tissue repair; trafficking; tryptamine 2,3 dioxygenase; vascular; vascular corrosion plaques; vascular erosion plaques; vascular plaque; vascular smooth muscle cell proliferation; vulnerable plaque",Immune Mechanisms in Atherosclerosis,"Inflammation-mediated damage of the atherosclerotic plaque causes plaque rupture and results in sudden blockage of blood flow, heart attacks, and strokes. The current application investigates how cells of the immune system, namely dendritic cells, are activated and how they regulate this unique type of inflammation.  In patient-derived atherosclerotic tissues, we will study how dendritic cells sense danger signals, such as  infections, and how they instruct T cells and macrophages to turn into tissue-attacking cells. Finally, we will  target dendritic cells in the atherosclerotic plaque and reeducate them into anti-inflammatory regulators, with the  ultimate goal of developing novel therapeutic interventions suppressing inflammation and promoting stabilization  of the atherosclerotic plaque",58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,372814
8016643,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5167,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"DUDLEY, SAMUEL C;",1916268;,5P01HL058000,,,"11-Decorticosterone; 21-Hydroxy-4-pregnene-3,20-dione; 21-Hydroxyprogesterone; 5,6,7,8-tetrahydrobiopterin; ANG-(1-8)Octapeptide; Acetates; Active Oxygen; Affect; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Animals; Aorta; Arginine; Arginine, L-Isomer; Atrial Fibrillation; Auricular Fibrillation; BH4; BPH4; Bioavailability; Biochemical; Biologic Availability; Biological Availability; Blood Pressure, High; Blood Vessels; Budgets; CNOS; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Cells; Clinical; Clinical Research; Clinical Study; Collaborations; Common Rat Strains; Constitutive NOS; Cortexone; Country; Cyclicity; Data; Dehydrogenases; Deoxycorticosterone; Desoxycorticosterone; Desoxycortone; Development; Diastolic Hypertension; Diastolic heart failure; Dietary Supplementation; Direct Costs; Disease; Disorder; Doctor of Medicine; Doctor of Philosophy; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; ENOS; Electron Transport; Electrons; Endocardium; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Dependent Relaxing Factors; Endothelium-Dependent Vasodilators; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxant Factor; Endothelium-Derived Relaxing Factor; Ensure; Event; Feedback; Functional disorder; Funding; Guanylyl Cyclase-Activating Factor Synthase; H4B; H4biopterin; HOSP; Health; Heart; Heart failure; Heart myocyte; Heme Group; Hospitalization; Human; Human, General; Hypertension; INFLM; Inflammation; Intracellular Communication and Signaling; Isoforms; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Left; Life Expectancy; Link; M.D.; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardium; Myocytes, Cardiac; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Negative Beta Particle; Negatrons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Oral; Outcome Measure; Output; Oxidases; Oxidation-Reduction; Oxidative Stress; Oxidoreductase; Oxygen; Oxygen Radicals; Oxygenases; Pathogenesis; Patients; Pb element; Periodicity; Peroxonitrite; Peroxonitrites; Peroxynitrites; Ph.D.; PhD; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiologic Availability; Physiological; Physiopathology; Play; Pregn-4-ene-3,20-dione, 21-hydroxy-; Prevalence; Principal Investigator; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; Protein Isoforms; Public Health; Rat; Rattus; Reactive Oxygen Species; Redox; Reductases; Relaxation; Renin-Angiotensin System; Reporting; Rhythmicity; Risk Factors; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sodium Chloride; Sodium chloride (NaCl); Source; Superoxide Anion; Superoxide Radical; Superoxides; Systolic heart failure; THBP; Techniques; Testing; United States; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Ventricular; abstracting; base; bioavailability of drug; biological signal transduction; cardiac failure; cardiac muscle; cardiomyocyte; cardiovascular disorder; constriction; disease/disorder; eNOS enzyme; electron transfer; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; heart failure with preserved systolic function; heart muscle; heavy metal Pb; heavy metal lead; hemodynamics; human NOS3 protein; hyperpiesia; hyperpiesis; hypertensive disease; improved; inhibitor; inhibitor/antagonist; interest; novel; oxidant stress; oxidation; oxidation reduction reaction; pathophysiology; peroxynitrite; prevent; preventing; programs; public health medicine (field); research study; salt; salt sensitive; social role; stem; tetrahydro-6-biopterin; tetrahydrobiopterin; treatment strategy; vascular",Oxidative Stress and Left Ventiricular Diastolic Function,,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,383975
8016644,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5168,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"DIKALOV, SERGEY ;",7685145;,5P01HL058000,,,"Active Oxygen; Arts; Biological; Blood Vessels; Body Tissues; Cardiovascular Diseases; Cells; Chemistry, Organic; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Collaborations; Core Facility; Cultured Cells; Detection; Development; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Free Radicals; H2O2; HPLC; High Pressure Liquid Chromatography; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hydroxylamine; INFLM; In Vitro; Individual; Inflammation; Institutes; Laboratories; Life; Measurement; Measures; Mediating; Membrane; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Monitor; Mononitrogen Monoxide; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organic Chemistry; Oxygen Radicals; Paramagnetic Resonance; Participant; Peroxidases; Preparation; Pro-Oxidants; Process; Production; Publications; Publishing; Reactive Oxygen Species; Research Specimen; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Sampling; Scientific Publication; Specimen; Spectroscopy, ESR; Spin Trapping; Superoxide Anion; Superoxide Radical; Superoxides; Techniques; Testing; Tissue Sample; Tissue membrane; Tissues; Training; Work; cardiovascular disorder; design; designing; dihydroethidium; electron paramagnetic resonance spectroscopy; endothelial cell derived relaxing factor; in vivo; membrane structure; nitrone; oxidant stress; oxidation; vascular",Electron Spin Resonance Core,,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,195763
8016645,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5169,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HILENSKI, LULA LAIL;",7685150;,5P01HL058000,,,"ANG-(1-8)Octapeptide; Actins; Active Oxygen; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Animal Disease Models; Animals; Aorta; Arterial Fatty Streak; Arteries; Arts; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Blood Pressure, High; Blood Vessels; Body Tissues; Bovine Species; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cattle; Cell/Tissue, Immunohistochemistry; Cells; Computer Assisted; Computer Programs; Computer software; Core Facility; Cultured Cells; Data; Detection; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Endothelial Cells; Equipment; Fluorescence; Fluorescence Microscopy; Goals; HTRPY; Histology; Human; Human, General; Hypertension; Hypertrophy; IHC; INFLM; Image; Image Analyses; Image Analysis; Imaging technology; Immunoblotting; Immunohistochemistry; Immunohistochemistry Staining Method; Individual; Inflammation; Inflammatory; Isoforms; Laser Scanning Confocal Microscopy; Lesion; Light Microscope; Location; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Messenger RNA; Methods; Mice; Mice, Transgenic; Microscope; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Murine; Mus; NADPH Oxidase; Organ System, Cardiovascular; Oxidation-Reduction; Oxygen Radicals; Paraffin; Paraffin waxes and Hydrocarbon waxes; Paramagnetic Resonance; Participant; Pathway interactions; Preparation; Pro-Oxidants; Production; Protein Isoforms; RNA, Messenger; ROC Analysis; Reactive Oxygen Species; Redox; Renal Tissue; Research Resources; Resources; Services; Signaling Molecule; Software; Spectroscopy, ESR; Staining method; Stainings; Stains; Streaks, Arterial Fatty; Supervision; System; System, LOINC Axis 4; Time; Tissues; Training Support; Transgenic Mice; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; blood vessel disorder; bone morphogenic protein; bovid; bovine; cardiovascular disorder; circulatory system; computer aided; computer imaging; computer program/software; confocal scanning microscopy; cow; digital imaging; electron paramagnetic resonance spectroscopy; experience; experiment; experimental research; experimental study; fluorescence imaging; hyperpiesia; hyperpiesis; hypertensive disease; image evaluation; imaging; immunocytochemistry; mRNA; mouse model; neovascularization; oxidant stress; oxidation reduction reaction; pathway; protein expression; research study; tissue processing; tool; vascular; vulnerable plaque",Imaging Core,,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,169153
8016646,P01,HL,5,,01/01/2010,12/31/2010,,5P01HL058000-12,5170,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HARRISON, DAVID G;",1866960;,5P01HL058000,,,"Administrator; Advisory Committees; Bio-Informatics; Bioinformatics; Budgets; Cardiology; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Communication; Computer Programs; Computer software; Data Set; Dataset; Ensure; Funding; Goals; Grant; INFLM; Inflammation; Investigators; Manuscripts; Monitor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Postdoc; Postdoctoral Fellow; Preparation; Programs (PT); Programs [Publication Type]; Progress Reports; Public Health Schools; Records; Reporting; Reports, Progress; Research Associate; Research Personnel; Research Resources; Researchers; Resources; Review Committee; SCHED; Schedule; Schools, Public Health; Services; Site Visit; Software; Specialist; Task Forces; Travel; United States National Institutes of Health; cardiovascular disorder; computer program/software; computerized; experiment; experimental research; experimental study; meetings; oxidant stress; post-doc; post-doctoral; programs; research study",Administrative Core,,58000,HLBP,"Heart, Lung, and Blood Program Project Review Committee",,12,,145680
7798028,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,,NINDS:1138115;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NEUROSURGERY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"ROBERTSON, CLAUDIA S;",2406941;,5P01NS038660,07/26/1999,01/31/2011,,Vascular Mechanisms of Secondary Injury After Traumatic Brain Injury,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,1138115,
8013929,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,0001,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"ROBERTSON, CLAUDIA S;",2406941;,5P01NS038660,,,"ARDS; ARDS, Human; ARDSs, Human; Accounting; Acquired brain injury; Acute; Adult RDS; Adult Respiratory Distress Syndrome; Adverse effects; Age Group Unspecified; Anemia; Autoregulation; Behavior assessment; Blood Pressure, High; Blood Transfusion; Blood Vessels; Blood flow; Brain; Brain Injuries; Bruise; CNOS; Cancers; Cardiovascular Diseases; Cause of Death; Cerebral perfusion pressure; Cerebrospinal Fluid; Cerebrovascular Circulation; Cerebrum; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Complement; Complement Proteins; Constitutive NOS; Contusions; Critical Illness; Critically Ill; Data; Disease; Disorder; Drugs; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; ENOS; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Erythropoiesis; Experimental Models; Experimental Models, Other; Functional disorder; Funding; Goals; Grant; Guanylyl Cyclase-Activating Factor Synthase; HOSP; Hemoglobin; Homeostasis; Hospitals; Human; Human, General; Hypertension; Incidence; Individual; Inflammatory Response; Injury; Intermediary Metabolism; Investigators; Ischemia; Isoforms; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lab Findings; Laboratories; Laboratory Finding; Life; Logic; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Medication; Metabolic; Metabolic Processes; Metabolism; Microdialysis; Modeling; Models, Experimental; Mononitrogen Monoxide; Myelopathy, Traumatic; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Natural History; Nervous System, Brain; Neurologic outcome; Neurological outcome; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Outcome; Oxygen; Pathology; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Play; Population; Pressure; Pressure- physical agent; Process; Production; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Isoforms; Public Health; Receptor Protein; Regulation; Reports, Progress; Research Personnel; Researchers; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Risk; Role; Sampling; Secondary to; Severities; Shock Lung; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Testing; Tissue Sample; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Treatment Side Effects; Unemployment; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Venous; Work; age group; behavioral assessment; brain damage; brain lesion (from injury); brain tissue; cardiovascular disorder; cerebral blood flow; cerebral circulation; cerebrocirculation; cerebrovascular; clinical investigation; design; designing; disease/disorder; drug/agent; eNOS enzyme; effective therapy; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; hemodynamics; high risk; human NOS3 protein; hyperpiesia; hyperpiesis; hypertensive disease; improved; injured; injury response; jobless; joblessness; malignancy; neoplasm/cancer; neurological recovery; neuropathology; neuroprotection; neuropsychological; out of work; pathophysiology; pressure; prevent; preventing; programs; public health medicine (field); receptor; receptor expression; recombinant human erythropoietin; response; response to injury; side effect; social role; spinal fluid; therapy adverse effect; traumatic brain damage; treatment adverse effect; unemployed; vascular",Effect of Eythropoietin on Vascular Dysfunction in Human Traumatic Brain Injury,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,244144
8013930,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,0002,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"VALADKA, ALEX B;",8587010;,5P01NS038660,,,"ARDS; ARDS, Human; ARDSs, Human; Accounting; Acquired brain injury; Acute; Adult RDS; Adult Respiratory Distress Syndrome; Adverse effects; Age Group Unspecified; Allogenic; Anemia; Area; Autoregulation; Behavior assessment; Bleeding; Blood; Blood Sample; Blood Transfusion; Blood Vessels; Blood erythrocyte; Blood normocyte; Blood specimen; Bone Marrow; Brain; Brain Injuries; Cancers; Cardiovascular Diseases; Carrying Capacities; Cause of Death; Cells; Cerebrovascular Circulation; Cerebrum; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Complex; Critical Care; Critical Illness; Critically Ill; Disease; Disorder; Dysfunction; ECSF; Elevated Intracranial Pressure; Encephalon; Encephalons; Epoetin; Erythrocyte Volume, Packed; Erythrocytes; Erythrocytic; Erythropoiesis; Erythropoietin; Functional disorder; Goals; Grant; Half-Life; Half-Lifes; Hct; Hematocrit; Hematocrit procedure; Hemoglobin; Hemorrhage; Homeostasis; Immune; Incidence; Infection; Inflammation Mediators; Injury; Intracranial Hypertension; Intracranial Pressure; Intracranial Pressure Elevation; Intracranial Pressure Increase; Investigation; Investigators; Laboratories; Life; Logic; Malignant Neoplasms; Malignant Tumor; Marrow erythrocyte; Nervous System, Brain; Neurologic outcome; Neurological outcome; Neuropsychologies; Neuropsychology; O element; O2 element; Observational Study; Outcome; Oxygen; Oxygen measurement, partial pressure, arterial; PRBC; PRBC Transfusion; Packed Red Blood Cell Transfusion; Packed Red-Cell Volume; Pathology; Patients; Patients with traumatic brain injury; Physiological Homeostasis; Physiopathology; Play; Population; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Prospective Studies; Public Health; Pulmonary Edema; Reaction; Receptor Protein; Recovery; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Personnel; Researchers; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Erythrocytes; Risk; Role; Saline; Saline Solution; Severities; Shock Lung; Subarachnoid Pressure; TBI Patients; TRNSF; Time; Transfusion; Transgenic Animals; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Treatment Side Effects; Unemployment; Vasodilatation; Vasodilation; Vasorelaxation; Work; age group; arterial pO2; behavioral assessment; blood corpuscles; blood loss; blood product; brain damage; brain lesion (from injury); brain tissue; cardiovascular disorder; cerebral blood flow; cerebral circulation; cerebrocirculation; cerebrovascular; clinical investigation; disease/disorder; effective therapy; erythrocyte colony stimulating factor; gain of function; hematopoietin; hemodynamics; improved; injured; jobless; joblessness; lung edema; malignancy; neoplasm/cancer; neurological recovery; neuropathology; neuropsychologic; novel; out of work; oxygen tension; pathophysiology; pressure; prevent; preventing; programs; public health medicine (field); randomized trial; receptor; recombinant human erythropoietin; response; side effect; social role; therapy adverse effect; traumatic brain damage; treatment adverse effect; unemployed; vascular",Effects of erythropoietin on anemia and need for transfusion,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,183385
8013931,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,0003,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"BRYAN, ROBERT M;",1882290;,5P01NS038660,,,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; Acids; Acquired brain injury; Actions of Nitric Oxide in the Heart; Address; Agonist; Animals; Arachidonic Acid Cyclooxygenase; Arachidonic Acids; Arteries; Arterioles; Attenuated; Blood Vessels; Blood flow; Body Tissues; Brain; Brain Injuries; COX; Caliber; Cerebral Arteries; Cerebral Ischemia; Cerebrovascular Circulation; Cerebrum; Characteristics; Common Rat Strains; Cyclo-Oxygenase; Cyclooxygenase; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Diameter; Dilator; Electromagnetic, Laser; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium; Endothelium, Vascular; Endothelium-Dependent Relaxing Factors; Endothelium-Dependent Vasodilators; Endothelium-Derived Relaxant Factor; Endothelium-Derived Relaxing Factor; Epoprostenol; Estrogenic Agents; Estrogenic Compounds; Estrogens; Fatty Acid Cyclo-Oxygenase; Goals; H2O2; Heart; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hydroperoxide Cyclase; Injury; Intermediary Metabolism; Intervention; Intervention Strategies; Investigators; Ischemia; Laser-Doppler Flowmetry; Lasers; Lead; METBL; Mammals, Rats; Measurement; Measures; Mediating; Membrane Potentials; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Middle Cerebral Artery Branch; Mononitrogen Monoxide; Muscle, Smooth, Vascular; Nervous System, Brain; Nitric Oxide; Nitric Oxide Pathway; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Optical Methods; Organ; P450; PGH Synthase; PGH2 Synthetase; PGI2; PGX; Pathway interactions; Pb element; Perfusion; Peripheral; Process; Production; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostacyclins; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin H Synthase; Prostaglandin H2 Synthetase; Prostaglandin I(2); Prostaglandin I2; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandins I; Radiation, Laser; Rat; Rattus; Regulation; Reperfusion Therapy; Research Personnel; Researchers; Resting Potentials; Structure of arteriole; Structure of cerebral artery; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic Estrogen; Tissues; Transmembrane Potentials; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Endothelium; arteriole; brain damage; brain lesion (from injury); cerebral artery; cerebral blood flow; cerebral circulation; cerebrocirculation; controlled cortical impact; endothelial cell derived relaxing factor; heavy metal Pb; heavy metal lead; in vivo; injured; insight; interventional strategy; neuroprotection; new therapeutics; next generation therapeutics; novel therapeutics; pathway; programs; prostaglandin X; relaxing factor; reperfusion; response; traumatic brain damage; treatment strategy; vascular",EDHF Following Traumatic Brain Injury,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,189920
8013932,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,0004,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"ROBERTSON, CLAUDIA S;",2406941;,5P01NS038660,,,"5,6,7,8-tetrahydrobiopterin; Acquired brain injury; Acute; Adverse effects; Agonist; Altitude; Animals; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Arginine; Arginine, L-Isomer; Autoregulation; BH4; BPH4; Back; Behavior assessment; Behavioral; Biological Preservation; Blood Vessels; Body Tissues; Brain; Brain Injuries; Bruise; CBF; CNOS; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Chronic; Clinical; Clinical Research; Clinical Study; Collaborations; Common Rat Strains; Constitutive NOS; Contralateral; Contusions; Core-Binding Factor; Critiques; Dorsum; Dose; Dysfunction; EC 1.14.13.39; ECNOS; ECSF; EDRF Synthase; ENOS; EPO-R; EPOR; EPOR gene; Effects, Longterm; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Epoetin; Erythrocyte Volume, Packed; Erythropoietin; Erythropoietin Receptor; Erythropoietin Receptor Gene; Experimental Models; Experimental Models, Other; Functional disorder; Future; Genes; Grant; Guanylyl Cyclase-Activating Factor Synthase; H4B; H4biopterin; Hct; Hematocrit; Hematocrit procedure; Homeostasis; Human; Human, General; In Vitro; Infarction; Injury; Intracellular Communication and Signaling; Investigators; Isoforms; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Laboratories; Logic; Long-Term Effects; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mice; Mice, Transgenic; Modeling; Models, Experimental; Mononitrogen Monoxide; Murine; Mus; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nervous System, Brain; Neurologic outcome; Neurological outcome; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Oxygen; Packed Red-Cell Volume; Pathologic Processes; Pathological Processes; Pathology; Patients; Peptide Receptor; Peptides; Perfusion; Phlebotomy; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Play; Preparation; Preservation, Biologic; Preservation, Biological; Process; Production; Programs (PT); Programs [Publication Type]; Protein Isoforms; Rat; Rattus; Receptor Protein; Recombinants; Recovery; Relative; Relative (related person); Research Design; Research Personnel; Researchers; Role; SAH; Safety; Secondary to; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stroke; Study Type; Subarachnoid Hemorrhage; THBP; Tissue Sample; Tissues; Training; Transgenic Mice; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Treatment Side Effects; Unemployment; Vascular Accident, Brain; Vascular constriction (function); Vasoconstriction; Vasodilating Agent; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Venous blood sampling; Work; behavioral assessment; biological signal transduction; brain attack; brain damage; brain lesion (from injury); brain tissue; cerebral blood flow; cerebral circulation; cerebral hypoperfusion; cerebral vascular accident; cerebrocirculation; cerebrovascular; cofactor; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; erythrocyte colony stimulating factor; experiment; experimental research; experimental study; hematopoietin; hemodynamics; human NOS3 protein; improved; infarct; injured; injury response; jobless; joblessness; mutant; neurological recovery; neuropathology; neuroprotection; neuropsychological; novel; out of work; overexpression; pathophysiology; preservation; programs; receptor; research study; response; response to injury; side effect; social role; spinal cord and brain injury; stroke; study design; tetrahydro-6-biopterin; tetrahydrobiopterin; therapy adverse effect; traumatic brain damage; treatment adverse effect; unemployed; vascular",Neuroprotection of Erythropoietin Signaling in Traumatic Brain Injury,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,162506
8013933,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,9001,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"GOODMAN, J C;",6594357;,5P01NS038660,,,"ATGN; Animals; Antigens; Arachidonic Acids; Blood Serum; Blood Vessels; Body Tissues; Bruise; Cerebrospinal Fluid; Contusions; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; ECSF; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Epoetin; Erythropoietin; Human; Human, General; INFLM; Inflammation; Injury; Intermediary Metabolism; Investigators; METBL; Man (Taxonomy); Man, Modern; Measurement; Measures; Metabolic Processes; Metabolism; Microscopic; Mononitrogen Monoxide; Neurochemistry; Nitrates; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; P450; Pathology; Programs (PT); Programs [Publication Type]; Receptor Protein; Research Personnel; Researchers; Sampling; Science of neurochemistry; Serum; Tissue Sample; Tissues; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; biomarker; endothelial cell derived relaxing factor; erythrocyte colony stimulating factor; experimental analysis; hematopoietin; human tissue; immunogen; neurochemistry; neuron cell death; neuron loss; neuronal cell death; neuronal loss; neuropathology; programs; receptor; response; spinal fluid; traumatic brain damage; vascular",Analytical & Neuropathology,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,124552
8013934,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,9002,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"HANNAY, JULIA H;",2798451;,5P01NS038660,,,"Acquired brain injury; Animals; Behavioral; Biochemical; Blood Vessels; Brain Injuries; Clinical Research; Clinical Study; Common Rat Strains; Head; Human; Human, General; Injury; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mice; Mice, Transgenic; Murine; Mus; Neurologic; Neurological; Outcome; Outcome Measure; Patients; Patients with traumatic brain injury; Rat; Rattus; TBI Patients; Transgenic Mice; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Work; behavior measurement; behavioral measure; behavioral measurement; brain damage; brain lesion (from injury); injured; neuropsychological; traumatic brain damage; vascular",Neurological and Other Outcomes Core,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,111614
8013935,P01,NS,5,,02/01/2010,01/31/2011,,5P01NS038660-10,9003,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"SWANK, PAUL R;",6652119;,5P01NS038660,,,"Advisory Committees; Analysis, Data; Animals; Banking, Tissue; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Blood Vessels; Caring; Clinical; Clinical Trials Data Monitoring Committees; Consultations; Data; Data Analyses; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; General Hospitals; Hospitals, General; Human; Human, General; Individual; Injury; Investigators; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Monitor; Patients; Procedures; Programs (PT); Programs [Publication Type]; Quality, Data; Randomized; Research Design; Research Personnel; Researchers; Rest; Safety; Safety Monitoring Boards; Science of Statistics; Statistics; Study Type; Task Forces; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; meetings; programs; randomisation; randomization; randomly assigned; statistics; statistics/biometry; study design; traumatic brain damage; vascular",Biostatistics & Administration,,38660,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,10,,121994
7754410,P30,AA,5,,01/01/2010,12/31/2010,AA-05-001,5P30AA005595-30,,NIAAA:1598082;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OAKLAND,UNITED STATES,,09,128663390,US,CA,946074046,PUBLIC HEALTH INSTITUTE,"GREENFIELD, THOMAS K;",1888346;,5P30AA005595,07/01/1981,12/31/2010,,Epidemiology of Alcohol Problems,,5595,ZAA1,Special Emphasis Panel,,30,1598082,
8015954,P30,AA,5,,01/01/2010,12/31/2010,,5P30AA005595-30,0001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OAKLAND,UNITED STATES,,09,128663390,US,CA,946074046,PUBLIC HEALTH INSTITUTE,"GREENFIELD, THOMAS K;",1888346;,5P30AA005595,,,"0-11 years old; 21+ years old; Accident and Emergency department; Accounting; Accounting, Demographic; Acculturation; Acculturations; Acute; Address; Adult; African American; Afro American; Afroamerican; Age; Age Group Unspecified; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcoholics Anonymous; Alcoholism; Alcohols; Application Context; Attitude; Beer; Black Populations; Black or African American; Censuses; Characteristics; Chemical Class, Alcohol; Child; Child Abuse; Child Youth; Childhood; Childhood Abuse; Children (0-21); Cohort Effect; Communities; Consumption; Country; Cultural Assimilation; Data; Data Sources; Demographic Accounting; Demography; Dependence; Drug usage; Drugs; Economic Income; Economical Income; Education; Educational aspects; Emergency Department; Emergency room; Employment; Employment Status; Enabling Factors; Environment; Environmental Factor; Environmental Risk Factor; Epidemiology; Epidemiology, Family Medical History; Esthesia; EtOH content; EtOH drinking; Ethanol dependence; Ethnic Origin; Ethnicity; Ethnicity aspects; Evaluation; Event; Factors, Enabling; Family; Family Medical History; Family history of; Feeling; Female; Frequencies (time pattern); Frequency; Gambling; Gamblings; Gender; General Population; General Public; Generation Effect; Grouping; Health Care Research; Health Services; Health Services Evaluation; Health Services Research; Healthcare Research; Heavy Drinker; Heavy Drinking; Hispanic Populations; Hispanics; Hispanics or Latinos; History; Home; Home environment; Household; Human, Adult; Human, Child; Impulsivity; Income; Individual; Injury; Insurance; Insurance Coverage; Insurance Status; Interpersonal Violence; Intervention; Intervention Strategies; Investigation; Knowledge; Latino Population; Literature; Marital Status; Marriage; Measurement; Measures; Mediating; Medical Care Research; Medication; Method LOINC Axis 6; Methodological Studies; Methodology; Methods and Techniques; Methods, Other; Modeling; Monitor; Orientation, Sexual; Outcome; Parents; Patients; Pattern; Personality; Personality Traits; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phone; Policy Maker; Population; Population Forecasts; Population Projection; Population Studies / Demography; Poverty; Predictive Value; Pressure; Pressure- physical agent; Prevalence; Prevention; Probability; Publications; Race; Racial Group; Recording of previous events; Reporting; Research; Respondent; Risk; Risk Factors; Role; SUBGP; Sales; Sampling; Scientific Publication; Sensation; Series; Services; Severities; Sex Orientation; Sexual abuse; Social Environment; Sources, Data; Spanish Origin; Special Population; Specialist; Status, Employment; Stocks, Racial; Studies, Methodological; Subgroup; Substance abuse problem; Survey Instrument; Surveys; Techniques; Telephone; Testing; Time; Trauma; Unmarried; Variant; Variation; Victimization; Violence; Weight; Wine; Woman; Work; abuse of substances; adult human (21+); adult youth; age group; aged; alcohol addiction; alcohol consequences; alcohol content; alcohol dependency; alcohol epidemiology; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol related consequences; alcohol related problem; alcohol services; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; base; black American; children; cohort; consumption measures; contextual factors; demographics; design; designing; drink heavily; drinking; drug use; drug/agent; early alcohol use; early onset; emerging adult; environmental risk; ethanol abuse; ethanol addiction; ethanol consumption; ethanol content; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol use disorder; ethanol-dependent; ethnic minority; ethnic minority population; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experience; extreme drinking; feelings; groupings; hazardous alcohol use; health care service; heavy alcohol use; help seeking; help-seeking behavior; hispanic community; improved; interventional strategy; legal drinking age; low socioeconomic status; male; men; men's; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; named group; pediatric; perpetrators; pressure; problem drinking; public policy on alcohol; racial/ethnic difference; response; services research; sex abuse; sexual violence; social; social climate; social context; social role; socioenvironment; substance abuse; theories; trend; violent; violent behavior; young adult; youngster",National Alcohol Survey (NAS),,5595,ZAA1,Special Emphasis Panel,,30,,1071253
8015955,P30,AA,5,,01/01/2010,12/31/2010,,5P30AA005595-30,0002,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OAKLAND,UNITED STATES,,09,128663390,US,CA,946074046,PUBLIC HEALTH INSTITUTE,"KERR, WILLIAM C;",7349176;,5P30AA005595,,,"Absolute ethanol; Age; Age Group Unspecified; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcoholic beverage heavy drinker; Alcohols; Area; BRFSS; Beer; Behavior; Behavior Risk Factor Surveillance System; Behavioral Risk Factor Surveillance System; Beverages; Blood Alcohol Content; Blood alcohol level measurement; Body Weight; California; Characteristics; Chemical Class, Alcohol; County; Data; Dependence; Development; Drug abuse; Drug usage; Drunk driving; ETOH; ETOH level; Economic Income; Economical Income; Education; Educational aspects; Ensure; Epidemiology; EtOH content; EtOH drinking; Ethanol; Ethnic Origin; Ethnicity; Ethnicity aspects; Evaluation Methodology; Focus Groups; Frequencies (time pattern); Frequency; Gender; General Population; General Public; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Grain Alcohol; Health; Heavy Drinker; Hispanic Populations; Hispanics; Hispanics or Latinos; Home; Home environment; Hour; Household; Incentives; Income; Individual; Instruction; Interview; Investigators; Knowledge; Latino Population; Low income; Maps; Marital Status; MeSH Descriptors Class 4; Measurement; Measures; Method LOINC Axis 6; Methodological Studies; Methodology; Methods; Methylcarbinol; Modeling; Orientation, Sexual; PYMT; Patient Self-Report; Pattern; Perception; Phone; Play; Population; Prevalence; Procedures; Reporting; Research; Research Personnel; Researchers; Respondent; Restaurants; Risk Behaviors; Risky Behavior; Role; Sales; Sampling; Self-Report; Series; Sex Orientation; Sexual abuse; Source; Spanish Origin; Statistical Methods; Studies, Methodological; Survey Instrument; Surveys; Technology; Telephone; Telephone Interviews; Time; Uncertainty; Validation; Variant; Variation; Visit; Voice; Weight; Wine; Woman; abuse of drugs; abuses drugs; age group; alcohol content; alcohol influenced driving; alcohol ingestion; alcohol intake; alcohol level; alcohol measurement; alcohol problem; alcohol product use; alcohol related problem; alcohol research; alcohol use; alcoholic beverage consumption; alcoholic drink intake; at risk behavior; base; blood alcohol concentration; blood alcohol level; computer based prediction; demographics; design; designing; doubt; drinking; drug use; drunken driving; ethanol abuse; ethanol consumption; ethanol content; ethanol drinking; ethanol influenced driving; ethanol ingestion; ethanol intake; ethanol measurement; ethanol product use; ethanol research; ethanol use; ethyl alcohol measurements; etoh use; geographic site; hazardous alcohol use; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; hispanic community; improved; incentive; inducement; metropolitan; payment; population survey; predictive modeling; problem drinking; response; risky sexual behavior; sex abuse; social role; standard measure; trend",Methodologies for Improving Measurement of Alcohol Consumption,,5595,ZAA1,Special Emphasis Panel,,30,,183817
8015956,P30,AA,5,,01/01/2010,12/31/2010,,5P30AA005595-30,9001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OAKLAND,UNITED STATES,,09,128663390,US,CA,946074046,PUBLIC HEALTH INSTITUTE,"BOND, JASON C;",9095317;,5P30AA005595,,,"Alcohol abuse; Alcohols; Analysis, Data; Area; Arts; Biostatistical Methods; Chemical Class, Alcohol; Communities; Computer Programs; Computer software; Consult; Consultations; Data; Data Analyses; Data Banks; Data Bases; Data Collection; Data Security; Data awareness; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Drug Formulations; Ensure; Epidemiology; Evolution; Formulation; Formulations, Drug; Goals; Grant; Human Resources; Infrastructure; Investigators; Maintenance; Maintenances; Manpower; Method LOINC Axis 6; Methodology; Methods; Motivation; Operation; Operative Procedures; Operative Surgical Procedures; Postdoc; Postdoctoral Fellow; Preparation; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; R01 Mechanism; R01 Program; RPG; Research; Research Associate; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Subjects; Researchers; Resources; Scientific Publication; Security; Security, Data; Series; Services; Software; Source; Substance abuse problem; Surgical; Surgical Interventions; Surgical Procedure; Survey Instrument; Surveys; System; System, LOINC Axis 4; Training; Work; abuse of substances; alcohol problem; alcohol research; clinical data repository; clinical data warehouse; computer program/software; data management; data repository; design; designing; ethanol abuse; ethanol research; hazardous alcohol use; information security; longitudinal analysis; personnel; post-doc; post-doctoral; problem drinking; programs; relational database; substance abuse; surgery; syntactic; syntax; technical writing; theories",Statistical and Data Services Infrastructure Core,,5595,ZAA1,Special Emphasis Panel,,30,,343012
7761750,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,,NCI:1365935;,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"TORTI, FRANK M;",1887613;,5P30CA012197,02/01/1997,01/31/2012,,Comprehensive Cancer Center of Wake Forest University,,12197,NCI,Subcommittee E - Prevention & Control,,35,1365935,
8016095,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9015,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"LEVINE, EDWARD A;",6166072;,5P30CA012197,,,"0-11 years old; Age; Archives; Banking, Tissue; Baptist Church; Baptists; Blood; Blood Plasma; Body Tissues; CCCWFU; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Patient; Cell Culture Techniques; Characteristics; Child; Child Youth; Children (0-21); Clinical; Code; Coding System; Collection; Comprehensive Cancer Center of Wake Forest University; Confidentiality of Patient Information; Consent; Consent Documents; Consent Forms; Core Grant; Crossmatching, Tissue; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Diagnostic; Drug or chemical Tissue Distribution; Ensure; Ethics Committees, Research; Floor; Freezing; Goals; HIPAA; HOSP; Health; Health Insurance Portability and Accountability Act; Health Sciences; Histocompatibility Testing; Histology; History; Hospitals; Human Resources; Human, Child; IRBs; Individual; Informed Consent Documents; Informed Consent Forms; Institution; Institutional Review Boards; Investigators; Kennedy Kassebaum Act; Laboratories; Language; Link; Liquid substance; Location; Maintenance; Maintenances; Manpower; Measures; Methods; Monitor; N element; N2 element; Neoplasms; Nitrogen; Normal Tissue; Normal tissue morphology; North Carolina; On-Line Systems; Online Systems; Outcome; P30 Grant; PL 104-191; PL104-191; Paraffin; Paraffin waxes and Hydrocarbon waxes; Pathology; Patients; Physicians; Plasma; Preparation; Procedures; Process; Protocol; Protocols documentation; Public Law 104-191; Quality Control; R01 Mechanism; R01 Program; RPG; Race; Racial Group; Recording of previous events; Recruitment Activity; Regulation; Research; Research Ethics Committees; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Specimen; Researchers; Resected; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Retrieval; Sampling; Secure; Security; Serum, Plasma; Services; Social Welfare; Specimen; Specimen Handling; Specimen Handlings; Specimen Processing; Stocks, Racial; Technology; Time; Tissue Banking; Tissue Banks; Tissue Collection; Tissue Crossmatchings; Tissue Distribution; Tissue Sample; Tissue Typing; Tissue/Specimen Collection; Tissues; Training; Tumor Bank; Tumor Tissue; Tumors; United States Health Insurance Portability and Accountability Act; Universities; Woman; anticancer research; caBIG; cancer Biomedical Informatics Grid; cancer research; children; clinical data repository; clinical data warehouse; data repository; demographics; design; designing; firewall; fluid; forest; histocompatibility typing; human tissue; liquid; member; neoplasia; neoplastic; neoplastic growth; online computer; patient confidentiality; patient population; personnel; prospective; recruit; relational database; repository; tissue fixing; tissue processing; tumor; web based; welfare; youngster",Tumor Tissue Core,,12197,NCI,Subcommittee E - Prevention & Control,,35,,115259
8016096,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9016,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"TORTI, FRANK M;",1887613;,5P30CA012197,,,"Animals; Award; Basic Research; Basic Science; Budgets; CCCWFU; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Science; Cancer Science; Cancer of Breast; Categories; Chair; Chairman; Chairperson; Chairwoman; Clinical Research; Clinical Study; Complementary and alternative medicine; Comprehensive Cancer Center of Wake Forest University; Core Grant; Crystallographies; Crystallography; Development; Funding; Genital System, Male, Prostate; Grant; Human; Human Prostate; Human Prostate Gland; Human, General; Image; Individual; Investigators; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; P30 Grant; Peer Review; Pilot Projects; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; Publications; Research; Research Personnel; Researchers; Resource Development; Resource Sharing; Science; Scientific Publication; Translational Research; Translational Research Enterprise; Translational Science; behavior measurement; behavioral measure; behavioral measurement; imaging; innovate; innovation; innovative; malignant breast neoplasm; member; novel; pilot study; programs; translation research enterprise; tumor",Developmental Funds,,12197,NCI,Subcommittee E - Prevention & Control,,35,,469684
8016097,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9019,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"DAGOSTINO, RALPH B.;",6963766;,5P30CA012197,,,"Analysis, Data; Area; Attention; Basic Research; Basic Science; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Biostatistics Core; CCCWFU; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Science; Cancers; Categories; Center for Cancer Research; Clinical; Clinical Research; Clinical Study; Clinical Trials, Monitoring; Clinical Trials, Phase III; Collaborations; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Computers; Consultations; Core Grant; Data Analyses; Development; Ensure; Faculty; Foundations; Funding; Genetic Research; Goals; Grant; Health Sciences; Hour; Incidence; Industry; Investigators; Laboratories; Malignant Neoplasms; Malignant Tumor; Manuscripts; Methodology, Research; Mission; Monitor; Monitoring Clinical Trials; Morbidity; Morbidity - disease rate; NCI Center for Cancer Research; NIH; National Institutes of Health; National Institutes of Health (U.S.); P30 Grant; Patient Recruitments; Peer Review; Peer Review, Research; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Preparation; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Protocols, Treatment; Public Health; Publishing; R01 Mechanism; R01 Program; RGM; RPG; Randomized; Recruitments, Patient; Regimen; Reporting; Research; Research Design; Research Grants; Research Methodology; Research Methods; Research Peer Review; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Review Committee; Role; Sampling; Scheme; Series; Services; Study Type; Survey Instrument; Surveys; Symptoms; System; System, LOINC Axis 4; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States National Institutes of Health; Universities; Work; Writing; anticancer research; cancer research; clinical practice; design; designing; experience; forest; health related quality of life; improved; malignancy; member; neoplasm/cancer; phase 3 study; phase 3 trial; phase III trial; programs; protocol development; protocol, phase III; public health medicine (field); randomisation; randomization; randomly assigned; response; social role; statistics/biometry; study design; study, phase III",Biostatistics Core,,12197,NCI,Subcommittee E - Prevention & Control,,35,,389654
8016098,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9026,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"TORTI, FRANK M;",1887613;,5P30CA012197,,,"Basic Research; Basic Science; CCCWFU; California; Cancer Center; Cancer Control; Cancer Control Science; Cancer Hospital; Cancers; Clinical; Clinical Research; Clinical Study; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Counselor; Doctor of Medicine; Elements; Epidemiologist; Evaluation; Funding; Generalized Growth; Growth; Hospital, Cancer; Hospitals, University; Hour; Individual; Institution; Investments; Knowledge; Lead; Leadership; M.D.; Malignant Neoplasms; Malignant Tumor; Michigan; Nature; North Carolina; Ohio; Oncologic Surgeon; Pb element; Prevention Research; Preventive Medicine; Professional counselor; Programs (PT); Programs [Publication Type]; Research; Research Institute; Resource Sharing; Schools, Medical; Sight; Sound; Sound - physical agent; Surgical Oncologist; Time; Tissue Growth; Training Programs; USC/Norris Comprehensive Cancer Center; USC/Norris Comprehensive Cancer Center and Hospital; Universities; University Hospitals; University of Southern California Norris Cancer Center; Vision; experience; heavy metal Pb; heavy metal lead; insight; malignancy; medical schools; meetings; member; neoplasm/cancer; ontogeny; preventative medicine; programs; sound; urologic; urological",Planning and Evaluation,,12197,NCI,Subcommittee E - Prevention & Control,,35,,25060
8016099,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9027,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"LIVELY, MARK O.;",1883490;,5P30CA012197,,,"Accounting; Analysis, Data; Area; Arts; Biotechnology; CCCWFU; Cancer Center; Cancers; Cellular Expansion; Cellular Growth; Chemicals; Clinical Research; Clinical Study; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Consult; Consultations; Custom; DNA; DNA Damage; DNA Injury; DNA Sequence; DNA Sequence Analysis; DNA laboratory; Data; Data Analyses; Deoxyribonucleic Acid; Doctor of Philosophy; Equipment; Experimental Designs; Funding; Grant; Gray; Gray unit of radiation dose; Hydrogen Oxide; Instrumentation, Other; Internet; Investigators; Ions; Laboratories; Laboratory Research; Lipids; Location; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Metabolic; NIH; National Institutes of Health; National Institutes of Health (U.S.); Oligo; Oligonucleotides; Peptide Synthesis; Peptides; Ph.D.; PhD; Photometry/Spectrum Analysis, Mass; Play; Programs (PT); Programs [Publication Type]; Protein Analysis; Protein Biochemistry; Protein/Amino Acid Biochemistry; Proteins; Proteomics; RNA chemical synthesis; RNA synthesis; Reporting; Research; Research Personnel; Research Resources; Research Support; Research, Laboratory; Researchers; Resources; Role; Sampling; Sequence Analyses, DNA; Sequence Analysis, DNA; Services; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Technology; Time; Triad; Triad Acrylic Resin; Triad resin; United States National Institutes of Health; WWW; Water; analytical method; anticancer research; cancer research; cell growth; cost; data acquisition; design; designing; experience; experiment; experimental research; experimental study; gene product; instrumentation; malignancy; mass spectrometer; measurement of metabolism; meetings; member; metabolomics; neoplasm/cancer; novel; peptide chemical synthesis; programs; protein chemical synthesis; research study; social role; web; world wide web",Biomolecular Resource Laboratory,,12197,NCI,Subcommittee E - Prevention & Control,,35,,152102
8016100,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9028,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"BERQUIN, ISABELLE M;",1890998;,5P30CA012197,,,"AIDS Virus; Abscission; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Back; Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; Budgets; CCCWFU; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer of Brain; Cancer-Promoting Gene; Cancers; Cell Culture Techniques; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; CellLine; Cells; Cellular Proliferation; Center for Cancer Research; Charge; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Cloning; Collaborations; Communities; Comprehensive Cancer Center of Wake Forest University; Core Grant; Cryofixation; Cryopreservation; Culturing, in vitro Vertebrate, Primary; Custom; DNA; DNA, Viral; Deoxyribonucleic Acid; Development; Dorsum; Drug Formulations; ELISA; EXTMR; Economic Income; Economical Income; Enzyme-Linked Immunosorbent Assay; Eperythrozoon; Excision; Extirpation; Extramural; Extramural Activities; Formulation; Formulations, Drug; Freezing; Genital System, Male, Prostate; Genomics; Grant; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Haemobartonella; Hepatitis Viruses; Human Immunodeficiency Viruses; Human Prostate; Human Prostate Gland; Human Resources; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Income; Institution; Investigators; LAV-HTLV-III; Laboratories; Laboratory Personnel; Lymphadenopathy-Associated Virus; Lytotoxicity; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Brain; Malignant neoplasm of brain; Manpower; Methods; Mission; Mycoplasma; NCI Center for Cancer Research; Oncogenes; P30 Grant; Peer Review, Research; Plaque Assay; Poxvirus officinale; Preparation; Primary Cell Cultures; Procedures; Production; Productivity; Prostate; Prostate Gland; Prostatic Gland; Quality Control; R01 Mechanism; R01 Program; RNA purification; RPG; Reagent; Recombinant Proteins; Removal; Research; Research Grants; Research Peer Review; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Retroviral Vector; Retrovirus Vector; SV 5; Savings; Services; Simian virus 5; Speed; Speed (motion); Surgical Removal; Technology; Testing; Tetracycline Antibiotic; Tetracyclines; Training; Transfection; Transforming Genes; Tumor-Specific Treatment Agents; Vaccinia virus; Virus; Virus-HIV; Viruses, General; Work; anticancer agent; anticancer drug; anticancer therapy; cancer therapy; cold preservation; cold storage; cultured cell line; cytotoxicity; experiment; experimental research; experimental study; human T cell leukemia virus III; human T lymphotropic virus III; malignancy; meetings; member; neoplasm/cancer; novel; personnel; prospective; recombinant vaccinia virus; repository; research study; resection; simian parainfluenza virus; tissue culture; tissue/cell culture; tool; vector; viral DNA; virus DNA",Cell Culture and Virus Vector Core,,12197,NCI,Subcommittee E - Prevention & Control,,35,,75785
8016101,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9029,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"WILLINGHAM, MARK C;",1873283;,5P30CA012197,,,"Animals; Basic Research; Basic Science; Biochemical; Blood leukocyte; CCCWFU; Cancer Center; Cancers; Cell Culture Techniques; Cell Death; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Cellular Expansion; Cellular Growth; Clinical; Comet Assay; Comprehensive Cancer Center of Wake Forest University; Confocal Microscopy; Consultations; Core Facility; DNA Damage; DNA Injury; Development; Electromagnetic, Laser; Electron Microscopy; Equipment; Expertise, Technical; Fluorescence; Fluorescence Microscopy; Gel Electrophoresis, Single-Cell; Genetic Alteration; Genetic Change; Genetic defect; Histology; Housing; Image; Imagery; Immune; Individual; Investigation; Investigators; Killings; Knowledge; Laboratories; Lasers; Leukocytes; Life; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Marrow leukocyte; Methods; Methods and Techniques; Methods, Other; Microdissection; Microinjections; Microscope; Microscopy; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mutation; Normal Cell; Pathway interactions; Peer Review; Phase; Preparation; Programs (PT); Programs [Publication Type]; Proteins; Radiation, Laser; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Leukocytes; Scanning; Services; Staining method; Stainings; Suggestion; System; System, LOINC Axis 4; Technical Expertise; Techniques; Technology; Transmission; Tumor Cell; UV laboratory microscope; Ultraviolet Microscopes; Virus; Viruses, General; Visualization; White Blood Cells; White Cell; cell determination; cell growth; cell imaging; cell sorting; cellular imaging; digital; digital video imaging; digital video recording; experience; fluorescence microscope; fluorescence/UV microscope; fluorescent microscope; gene product; genome mutation; imaging; instrument; laboratory fluorescence light microscope; malignancy; meetings; member; necrocytosis; neoplasm/cancer; neoplastic cell; new technology; pathway; programs; success; time use; tool; transmission process; white blood cell; white blood corpuscle",Cellular Imaging Core,,12197,NCI,Subcommittee E - Prevention & Control,,35,,63729
8016102,P30,CA,5,,02/01/2010,01/31/2011,,5P30CA012197-35,9030,,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"CHEN, YONG Q;",1896077;,5P30CA012197,,,Area; Bio-Informatics; Bioinformatics; CCCWFU; Cancer Center; Color; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Computer Work stations; Computer Workstations; Consultations; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Doctor of Philosophy; Experimental Designs; Faculty; Generations; Infrastructure; Microarray Analysis; Microarray-Based Analysis; Mission; Ph.D.; PhD; Price; Research Infrastructure; Services; Speed; Speed (motion); Technology; anticancer research; base; cancer research; interest; member; microarray technology; pricing; tool,Microarray Core,,12197,NCI,Subcommittee E - Prevention & Control,,35,,74662
7808799,P30,CA,5,,01/15/2010,11/30/2010,,5P30CA023108-32,,NCI:3290263;,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,PEDIATRICS,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"ISRAEL, MARK A;",1867907;,5P30CA023108,08/04/1997,11/30/2013,,Cancer Center Support Grant,,23108,NCI,Subcommittee E - Prevention & Control,,32,3290263,
8014990,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5590,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"ISRAEL, MARK A;",1867907;,5P30CA023108,,,"Area; Bio-Informatics; Bioinformatics; CCSG; Cancer Center; Cancer Center Director; Cancer Center Support Grant; Cancer Control; Cancer Control Science; Cancer Science; Cancer Survivorship; Cancers; Caring; Center for Cancer Research; Charge; Clinic; Clinical; Clinical Research; Clinical Study; Collaborations; Core Grant; Counseling; Decision Making; Development; Director of Cancer Research Center; Doctor of Medicine; E-Mail; Electronic Mail; Email; Emergent Technologies; Emerging Technologies; Ensure; Faculty; Fostering; Future; Genomics; Grant; Image; Infrastructure; Institution; International; Investigators; Investments; Israel; Laboratories; Leadership; Lectures; Lectures (PT); Lectures [Publication Type]; Location; M.D.; Malignant Neoplasms; Malignant Tumor; NCI Center for Cancer Research; Nanoscale Science; Nanotechnology; Outcomes Research; P30 Grant; Parents; Patients; Phone; Population Sciences; Principal Investigator; Program Evaluation; Programs (PT); Programs [Publication Type]; Proteomics; Research; Research Infrastructure; Research Personnel; Research, Outcomes; Researchers; Resource Sharing; Secure; Series; Services; Shapes; Sight; Strategic Planning; Study Section; Telephone; Underserved Population; Vision; anticancer research; cancer research; cancer research center director; clinical care; experience; imaging; improved; insight; lectures; malignancy; meetings; member; nano scale Science; nano tech; nano technology; nanotech; neoplasm/cancer; programs; under served population; underserved people",SENIOR LEADERSHIP,,23108,NCI,Subcommittee E - Prevention & Control,,32,,413785
8014991,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5608,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"ISRAEL, MARK A;",1867907;,5P30CA023108,,,"Area; CCSG; Cancer Center; Cancer Center Support Grant; Cancers; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Consult; Core Grant; Editorial Comment; Editorial Comment (PT); Ensure; Evaluation; Evolution; Faculty; Funding Mechanisms; Image; Infrastructure; Institution; Malignant Neoplasms; Malignant Tumor; New Hampshire; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; P30 Grant; Participant; Process; Programs (PT); Programs [Publication Type]; Public Health; Published Comment; Reporting; Research; Research Infrastructure; Resource Sharing; Strategic Planning; Viewpoint; Viewpoint (PT); Writing; anticancer research; cancer research; clinical investigation; imaging; insight; malignancy; meetings; neoplasm/cancer; population based; programs; public health medicine (field); response",PROGRAM PLANNING AND EVALUATION,,23108,NCI,Subcommittee E - Prevention & Control,,32,,25674
8014992,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5616,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"ISRAEL, MARK A;",1867907;,5P30CA023108,,,"CCSG; Cancer Center; Cancer Center Support Grant; Cancer Research Programs; Cancer Research Project; Clinical; Core Grant; Cotton Plant; Development; Endowment; Faculty; Five-Year Plans; Fostering; Funding; Goals; Gossypium; Infrastructure; Investments; Method LOINC Axis 6; Methodology; P30 Grant; Pilot Projects; Plans, Five-Year; Research; Research Infrastructure; Research Resources; Resource Sharing; Resources; Source; Technology; Work; anticancer research; base; cancer research; cotton; meetings; pilot study",DEVELOPMENTAL FUNDS,,23108,NCI,Subcommittee E - Prevention & Control,,32,,506719
8014993,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5635,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"GERLACH, ROBERT W;",7705444;,5P30CA023108,,,"Accountability; Accounting; Achievement; Achievement Attainment; Active Follow-up; Address; Administrator; Advertising; American Cancer Society; Animals; Appointment; Appropriateness Review; Articulation; Award; Back; Bio-Informatics; Bioinformatics; Bioinformatics Shared Resource; Biology; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Budgets; Businesses; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Science; Cancer Research Programs; Cancer Research Project; Cancer of Lung; Cancers; Case Report Form; CaseReportForm; Characteristics; Charge; Clinical; Clinical Oncology; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Commit; Communication; Communities; Comprehensive Cancer Center; Computer Programs; Computer software; Computers; Consultations; Contracting Opportunities; Contracts; Core Facility; Core Grant; Cotton Plant; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Decision Making; Development; Director of Nursing; Discipline; Disease; Disorder; Doctor of Philosophy; Dorsum; ELIG; Educational workshop; Effectiveness; Electronics; Eligibility; Eligibility Determination; Ensure; Equilibrium; Evaluation; Event; Ewing's Family of Tumours; Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Ewing's Tumor; Ewings sarcoma; Expenditure; Faculty; Family; Financial Management; Floor; Funding; Funding Mechanisms; Generalized Growth; Genomics; Gibbons; Goals; Gossypium; Grant; Growth; Health Policy; Human Resources; Hylobates; Hylobates Genus; IT Systems; Image; Individual; Information Systems; Information Technology; Information Technology Systems; Infrastructure; Institutes; Institution; Intellectual Property; International; Investigators; Job Environment; Job Location; Job Place; Job Setting; Job Site; Joints; Laboratories; Lead; Leadership; Lectures; Lectures (PT); Lectures [Publication Type]; Link; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Manpower; Medical center; Mission; Modeling; Monitor; News; News (PT); News [Publication Type]; Nomascus; Nurse Administrator; Nurse Executive; Nursing Research; Occupational activity of managing finances; Office Management; On-Line Systems; Oncology Group; Online Systems; Operation; Operative Procedures; Operative Surgical Procedures; Organ; P30 Grant; PYMT; Parents; Patient Care; Patient Care Delivery; Patients; Pb element; Peer Review; Ph.D.; PhD; Philanthropic Fund; Pilot Projects; Plant Embryos; Play; Policies; Population Study; Position; Positioning Attribute; Price; Procedures; Process; Programs (PT); Programs [Publication Type]; Proteomics; Protocol; Protocol Screening; Protocols documentation; Publications; Pulmonary Cancer; Pulmonary malignant Neoplasm; Quality Control; R01 Mechanism; R01 Program; RPG; Recommendation; Records; Recruitment Activity; Reporting; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Support; Researchers; Resource Development; Resource Sharing; Resources; Review, Appropriateness; Role; SCHED; Safety; Salaries; Schedule; Schools, Medical; Scientific Publication; Secure; Seeds; Services; Sight; Software; Strategic Planning; Supervision; Surgical; Surgical Interventions; Surgical Procedure; Symphalangus; System; System, LOINC Axis 4; Systems, Data; Tea; Technology; Technology Transfer; Tissue Growth; Update; Vice President for Nursing; Vision; Wages; Work; Work Location; Work Place; Work-Site; Workplace; Workshop; Worksite; Zygotes, Plant; anticancer research; balance; balance function; base; cancer research; clinical data repository; clinical data warehouse; clinical investigation; clinical practice; college; computer network; computer program/software; conference; cotton; data repository; design; designing; disease/disorder; feeding; follow-up; health care policy; heavy metal Pb; heavy metal lead; imaging; innovate; innovation; innovative; interdisciplinary collaboration; interest; lectures; lung cancer; malignancy; medical schools; meetings; member; neoplasm immunology; neoplasm/cancer; news; online computer; ontogeny; payment; personnel; pilot study; pricing; programs; recruit; relational database; response; satisfaction; seed; sharing data; social role; statistics/biometry; success; surgery; symposium; tumor immunology; web based; web site; work environment; work setting; working group",CANCER CENTER ADMINISTRATION,,23108,NCI,Subcommittee E - Prevention & Control,,32,,344329
8014994,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5646,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"KARAGAS, MARGARET RITA;",1874880;,5P30CA023108,,,"2-(Acetyloxy)benzoic Acid; Acetylsalicylic Acid; Address; Animal Model; Animal Models and Related Studies; Animals; Area; Aspergum; Aspirin; Bio-Informatics; Bioinformatics; Biological; Biological Factors; Biological Models; CCSG; Cancer Burden; Cancer Cause; Cancer Causing Agents; Cancer Center Support Grant; Cancer Etiology; Cancers; Carcinogens; Causality; Cell model; Cellular model; Chemoprevention; Chemopreventive; Chemopreventive Agent; Clinic; Clinical; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Cohort Studies; Collaborations; Colonic Polyps; Colorectal Adenoma; Colorectal Adenomatous Polyp; Communities; Concurrent Studies; Core Grant; Cutaneous Squamous Cell Carcinoma; Cyclins; Detection; Development; Disease; Disorder; Dose; Ecotrin; Empirin; Entericin; Environmental Exposure; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiologist; Epidemiology Research; Epidermoid Skin Carcinoma; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Etiology; Extren; Factor, Biologic; Fostering; Funding; General Population; General Public; Genetic; Goals; Human; Human papilloma virus infection; Human papillomavirus infection; Human, General; In Vitro; Incidence; Interdisciplinary Research; Interdisciplinary Study; International; Intervention; Intervention Strategies; Investigation; Investigators; Laboratories; Laboratory Scientists; Large Bowel Adenoma; Large Bowel Adenomatous Polyp; Large Intestine Adenoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Measurin; Mice; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Target; Multidisciplinary Collaboration; Multidisciplinary Research; Murine; Mus; National Cancer Burden; Natural Products; Neoplasms, Metachronous; Neoplasms, Metachronous Second Primary; Neoplasms, Second Primary; Observational Study; Oncogens; P30 Grant; Paper; Pathway interactions; Pharmacodynamics; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Placebo Control; Polyps; Population; Pre-Malignant; Predisposition; Premalignant; Prevention; Prevention strategy; Preventive strategy; Programs (PT); Programs [Publication Type]; Protein Cleavage; Proteins; Proteolysis; Public Health; Publishing; R01 Mechanism; R01 Program; RPG; Randomized; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Risk; Science; Scientific Advances and Accomplishments; Scientist; Scientists, Laboratory; Second Malignancy; Second Neoplasm; Second Primary Neoplasms; Squamous cell carcinoma of skin; Study, Interdisciplinary; Supplementation; Susceptibility; Testing; Transgenic Organisms; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Translations; Work; anticarcinogenic; base; bench bed side; bench bedside; bench to bed side; bench to bedside; biomarker; cancer epidemiology; cancer progression; case control; clinical efficacy; clinical investigation; clinical practice; colon polyp; cost; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; early life exposure; gene product; genetic risk factor; improved; inherited factor; interventional strategy; language translation; malignancy; member; model organism; multidisciplinary; neoplasm progression; neoplasm/cancer; neoplastic progression; new technology; novel; pathway; patient population; phase 3 study; phase 3 trial; phase III trial; population based; precancerous; prevent; preventing; programs; protocol, phase III; public health medicine (field); randomisation; randomization; randomly assigned; response; scientific accomplishments; scientific advances; skin squamous cell carcinoma; study, phase III; transgenic; translation research enterprise; tumor; tumor progression",CANCER EPIDEMIOLOGY AND CHEMOPREVENTION PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,67997
8014995,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5652,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"SARGENT, JAMES D.;",1876486;,5P30CA023108,,,"APOE [{C0003595}]; Accounting; Adolescent; Adolescent Youth; Adoption; Adverse effects; Alleles; Allelomorphs; Apo-E; ApoE; Apolipoprotein E; Area; Articulation; Behavior; CCSG; Cancer Center Support Grant; Cancer Control; Cancer Control Research Program; Cancer Control Science; Cancer Patient; Cancer Screening for Patients; Cancer Survivor; Cancer Treatment; Collaborations; Communication; Communication Research; Communities; Complication; Continuity of Care; Continuity of Patient Care; Continuum of Care; Core Grant; Delivery of Health Care; Development; Diagnosis; Doctor of Philosophy; Drugs; Early Diagnosis; Ensure; Exposure to; Fostering; Funding; Goals; Health Campaign; Health Care Research; Health Sciences, Allied and Health Services Delivery; Health Services Evaluation; Health Services Research; Healthcare Delivery; Healthcare Research; Individual; Investigators; Joints; Lead; MMG; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammogram; Mammography; Manuscripts; Medical Care Research; Medication; Mentorship; Mission; Mortality; Mortality Vital Statistics; P30 Grant; Patients; Pb element; Peer Review; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Prevention; Primary Care; Primary Health Care; Primary Healthcare; Programs (PT); Programs [Publication Type]; Public Health; Publications; Publishing; QOC; QOL; Quality of Care; Quality of life; Research; Research Personnel; Research Resources; Researchers; Resources; Risk Behaviors; Risk Reduction; Risky Behavior; Scientific Publication; Screening for cancer; Screening procedure; Smoke; Smoking; Structure; The Sun; Training Programs; Translating; Translatings; Translations; Treatment Side Effects; Work; adolescent smoking; anticancer therapy; at risk behavior; base; cancer care; cancer risk; cancer therapy; care systems; cognitive function; dissemination research; drug/agent; early cancer detection; early detection; health care delivery; heavy metal Pb; heavy metal lead; high risk; improved; juvenile; juvenile human; language translation; mammography registry; meetings; member; movie; novel; programs; public health medicine (field); screening; screenings; services research; side effect; successful intervention; systems of care; therapy adverse effect; treatment adverse effect",CANCER CONTROL RESEARCH PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,71737
8014996,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5657,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"EASTMAN, ALAN R;",1867959;,5P30CA023108,,,"(SP-4-2)-Diamminedichloroplatinum; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Basic Research; Basic Science; Biologic Monitoring; Biological Monitoring; Biopsy; CCSG; CDDP; Cancer Center; Cancer Center Support Grant; Cancer Patient; Cancer Treatment; Cancer of Breast; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Signaling; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Collaborations; Core Grant; Cotton Plant; Cysplatyna; DDP; Development; Diagnosis; Dichlorodiammineplatinum; Disease; Disease Outcome; Disorder; Drug effect disorder; Drugs; EC 2.3.1.85; Early-Stage Clinical Trials; Faculty; Fatty Acid Synthetase Complex; Fatty-acid synthase; Fostering; Funding; Goals; Gossypium; Hedgehog (Hh) signal transduction pathway; Induction Therapy; Intracellular Communication and Signaling; Investigation; Investigators; MCL1 protein; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Pancreatic Neoplasm; Malignant Tumor of the Breast; Malignant neoplasm of breast; Malignant neoplasm of pancreas; Mcl-1 protein; Medication; Molecular; Molecular Target; Monitoring, Biological; NEOADJ; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Neoadjuvant; Neoadjuvant Therapy; Neoadjuvant Treatment; New Agents; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Outcome; P30 Grant; Pancreas Cancer; Pancreatic Cancer; Paper; Pathway interactions; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Productivity; Programs (PT); Programs [Publication Type]; Proteasome Inhibitor; Proteins; Publications; Research; Research Personnel; Researchers; Role; Scientific Publication; Series; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic; Therapeutic Clinical Trial; Therapeutic Human Experimentation; Therapeutic Research; Translating; Translatings; Translations; Tumor Tissue; anticancer therapy; biological signal transduction; biomonitoring; cancer progression; cancer therapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; clinical applicability; clinical application; clinical investigation; cotton; disease/disorder; drug action; drug discovery; drug/agent; expectation; gene product; hedgehog signaling pathway; hh signaling pathway; improved; induced myeloid leukemia cell differentiation protein Mcl-1; inhibitor; inhibitor/antagonist; language translation; malignant breast neoplasm; member; myeloid cell factor-1; myeloid cell leukemia sequence 1; neoplasm progression; neoplastic progression; new approaches; new technology; new therapeutics; next generation therapeutics; nonsmall cell lung cancer; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; pathway; phase 1 study; phase 1 trial; phase I trial; programs; protocol, phase I; smoothened signaling pathway; social role; treatment strategy; tumor; tumor growth; tumor progression",MOLECULAR THERAPEUTICS RESEARCH PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,53208
8014997,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5665,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"BRENNER, CHARLES M;",1944030;,5P30CA023108,,,"Anti-Oncogenes; Antioncogenes; Apoptosis Regulator; Basic Research; Basic Science; Biological Factors; Blood; Breast; CCOP; CCSG; Cancer Center Support Grant; Cancer Induction; Cancer Research Programs; Cancer Research Project; Cancer Treatment; Cancer of Lung; Cancer stem cell; Cancers; Cell Cycle; Cell Division Cycle; Cessation of life; Chimera Protein; Chimeric Proteins; Classification; Clinical; Collaborations; Community Clinical Oncology Program; Community Oncology; Complex; Core Grant; Death; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Emerogenes; Factor, Biologic; Fostering; Funding; Fusion Protein; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Suppressor; Genetic Condition; Genetic Diseases; Genotype; Goals; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic Cancer; Hereditary Disease; Incidence; Intestinal; Intestines; Investigators; Lead; Leadership; Lung; Malignant Hematologic Neoplasm; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Medical center; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mission; Molecular; Molecular Disease; Mother Cells; Natural Products; Neoplasm Metastasis; Nerve Degeneration; Neuron Degeneration; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncology Programs; P30 Grant; Pain; Painful; Paper; Pathway interactions; Pb element; Population; Prevention; Progenitor Cells; Programs (PT); Programs [Publication Type]; Publishing; Pulmonary Cancer; Pulmonary malignant Neoplasm; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Resource Sharing; Respiratory System, Lung; Reticuloendothelial System, Blood; Role; Schools, Medical; Scientist; Second-Site Suppressor Genes; Secondary Neoplasm; Secondary Tumor; Stem cells; Suppressor Genes; Systematics; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Tumor Cell Migration; Tumor Suppressing Genes; Tumor Suppressor Genes; angiogenesis; anticancer therapy; bowel; cancer diagnosis; cancer metastasis; cancer therapy; carcinogenesis; carcinogenesis inhibitor; chemotherapy; college; cost; disease classification; disease/disorder classification; disorder classification; gene discovery; genetic disorder; heavy metal Pb; heavy metal lead; hereditary disorder; interdisciplinary collaboration; interest; language translation; lung cancer; malignancy; medical schools; meetings; member; mouse model; neoplasm/cancer; neural degeneration; neuro-oncology; neurodegeneration; neuronal degeneration; nosology; oncosuppressor gene; pathway; programs; pulmonary; small molecule; social role; translation research enterprise",CANCER MECHANISMS RESEARCH PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,26396
8014998,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5667,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"NOELLE, RANDOLPH J.;",1868200;,5P30CA023108,,,"Active Immunization; Adenocarcinoma, Renal Cell; Antineoplastic Vaccine; Area; Astrocytoma, Grade IV; CCSG; Cancer Center Support Grant; Cancer Vaccine Related Development; Cancer Vaccines; Cancer of Breast; Cancers; Carcinoma, Hypernephroid; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Core Grant; Dendritic Cells; Development; Faculty; Funding; Future; Glioblastoma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Grawitz Tumor; Human; Human, General; Hypernephroma; ITX; Immune response; Immunity; Immuno-Chemotherapy; Immunochemotherapy; Immunologic Monitoring; Immunologically Directed Therapy; Immunologist; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosurveillance; Immunotherapy; Immunotherapy, Cancer, General; Laboratories; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Measures; Mediating; Monitor; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; Multiple Myeloma; Myeloma, Plasma-Cell; Nephroid Carcinoma; P30 Grant; Paper; Pilot Projects; Programs (PT); Programs [Publication Type]; Publishing; Renal Adenocarcinoma; Renal Cell Cancer; Renal Cell Carcinoma; Renal Cell Carcinoma, Stage Unspecified; Research; Resource Sharing; Role; Sight; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; Translations; Tumor Immunity; Tumor Suppression; Tumor Suppression, Molecular; Vaccinated; Vaccine Related Development, Cancer; Vaccines; Vaccines, Neoplasm; Vaccines, Tumor; Veiled Cells; Vision; Work; adenocarcinoma of kidney; base; cancer immunotherapy; cancer vaccine development; cell mediated immune response; clinical investigation; design; designing; experience; glioblastoma multiforme; host response; immune therapy; immunoresponse; malignancy; malignant breast neoplasm; melanoma; member; myeloma; myelomatosis; neoplasm/cancer; pilot study; programs; social role; spongioblastoma multiforme; thymus derived lymphocyte; tumor; working group",IMMUNOLOGY AND CANCER IMMUNOTHERAPY RESEARCH PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,71737
8014999,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5670,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"PAULSEN, KEITH D.;",1888023;,5P30CA023108,,,"Abscission; Absorption; Animals; Award; Biological; Biomedical Engineering; Biophysics; Brain; Breast; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Diagnostics; Cancer Patient; Cancer Radiotherapy; Cancer Treatment; Cancer of Breast; Cancers; Clinical; Clinical Evaluation; Clinical Research; Clinical Sciences; Clinical Study; Clinical Testing; Collaborations; Core Grant; Data; Decision Making; Detection; Development; Diagnostic; Diagnostics, Cancer; Disease; Disorder; Dose; Effectiveness; Electrical Impedance; Electromagnetic, Microwave; Encephalon; Encephalons; Engineering; Engineerings; Event; Excision; Extirpation; Faculty; Fever; Fluorescence; Funding; Funding Mechanisms; Genital System, Male, Prostate; Goals; Head and Neck; Head and neck structure; Human Prostate; Human Prostate Gland; Hyperthermia; Image; Imaging Procedures; Imaging Techniques; Imaging technology; Impedance; Instrumentation, Other; International; Investigation; MMG; Magnetic Resonance; Magnetic Resonance Elastography; Magnetism; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammogram; Mammography; Measurement; Mediating; Medical; Methods; Methods and Techniques; Methods, Other; Microwaves; Modality; Nanoscale Science; Nanotechnology; Nervous System, Brain; O element; O2 element; Outcome; Oximetry; Oxygen; Oxygen saturation measurement; P30 Grant; Paper; Peer Review; Physicians; Physiologic; Physiological; Process of absorption; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; Publications; Pyrexia; Radiation; Radiation Biology; Radiation therapy; Radiobiology; Radiotherapeutics; Radiotherapy; Removal; Research; Research Activity; Research Resources; Resource Sharing; Resources; Scientific Publication; Series; Site; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Structure; Surgical Removal; System; System, LOINC Axis 4; Technical Report; Technical Report (PT); Technical Report [Publication Type]; Technics, Imaging; Techniques; Therapeutic; Therapeutic Clinical Trial; Translating; Translatings; Translations; absorption; anticancer therapy; bench bed side; bench bedside; bench to bed side; bench to bedside; bioengineering; bioengineering/biomedical engineering; cancer diagnosis; cancer imaging; cancer therapy; clinical test; cost; disease/disorder; driving force; electric impedance; febrile; febris; imaging; imaging modality; improved; in vivo; infrastructure development; innovate; innovation; innovative; instrumentation; interest; irradiation; language translation; magnetic; malignancy; malignant breast neoplasm; member; microwave electromagnetic radiation; microwave radiation; nano materials; nano particle; nano scale Science; nano tech; nano technology; nanomaterials; nanoparticle; nanotech; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; pre-clinical; preclinical; programs; ray (radiation); research clinical testing; research facility; resection; technical report; tool; treatment strategy; tumor",CANCER IMAGING AND RADIOBIOLOGY RESEARCH PROGRAM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,64099
8015000,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5674,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"LEWIS, LIONEL DAVID;",6793950;,5P30CA023108,,,"Aliquot; Analysis, Data; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Applications Grants; Arts; Assay; Back; Bar Codes; Benzenebutanoic acid, alpha,2-diamino-gamma-oxo-; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Blood Coagulation Factor IV; Blood Plasma; Body Tissues; Budgets; CCSG; CPC9; CPD6; CYP2C10; CYP2C9; CYP2C9 gene; CYP2D; CYP2D6; CYP2D6 gene; CYP2DL1; Ca++ element; Calcium; Cancer Center; Cancer Center Support Grant; Cancer Drug; Cancer, Oncology; Cancers; Cells; Chemoprevention, Clinical; Chemotherapeutic Agents, Neoplastic Disease; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinical; Clinical Chemoprevention; Clinical Oncology; Clinical Pharmacology; Clinical Protocols; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Coagulation Factor IV; Codes, Bar; Computers; Concentration measurement; Consultations; Core Grant; DNA Molecular Biology; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Detection; Development; Documentation; Dorsum; Drug Kinetics; Drug Therapy; Drugs; Drugs, Investigational; EPEG; Enrollment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Eposide; Etoposide; Evaluation; Evaluation Studies; Factor IV; Fluorescence; Folate; Funding; Future; Genetic Polymorphism; Grant Proposals; Grants, Applications; HPLC; Head and Neck, Saliva; Hemoglobin; High Pressure Liquid Chromatography; In Vitro; Individual; Investigational Drugs; Investigational New Drugs; Investigators; Kynurenine; L-Tryptophan; Laboratory Research; Lastet; Leadership; Learning; Levotryptophan; Liquid substance; Mails; Malignant Neoplasms; Malignant Tumor; Measurement; Measures; Medication; Method LOINC Axis 6; Methodology; Modeling; Molecular Biology; Monitor; N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; Nursing Research; Oncology Group; P30 Grant; P450 MP-4; P450 PB-1; P450-DB1; P450C2D; P450IIC9; PBMC; Patient Care; Patient Care Delivery; Patients; Performance; Peripheral Blood Mononuclear Cell; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmaceutical Services; Pharmacies; Pharmacists; Pharmacodynamics; Pharmacogenetics; Pharmacogenomics; Pharmacokinetics; Pharmacology Shared Resource; Pharmacology, Clinical; Pharmacotherapy; Pharmacy facility; Phase; Pilot Projects; Plasma; Polymorphism (Genetics); Polymorphism, Genetic; Pre-Clinical Model; Preclinical Models; Printing; Process; Protocol; Protocols documentation; Reader; Research; Research Design; Research Personnel; Research Resources; Research Specimen; Research, Laboratory; Researchers; Resource Sharing; Resources; Reticuloendothelial System, Serum, Plasma; Saliva; Sampling; Scanning; Serum, Plasma; Services; Services, Pharmaceutic; Services, Pharmacy; Source; Specimen; Study Type; System; System, LOINC Axis 4; Taxotere; Technology; Testing; Therapeutic Studies; Therapy Research; Tissue Sample; Tissues; Tryptophan; Tumor Tissue; Tumor-Specific Treatment Agents; Urinary System, Urine; Urine; Vepesid; Work; Zebra; anticancer agent; anticancer drug; anticancer research; biobank; cancer research; clinical data repository; clinical data warehouse; clinical investigation; cost; data repository; design; designing; docetaxel; docetaxol; drug/agent; enroll; experiment; experimental research; experimental study; fluid; in vivo; liquid; malignancy; member; neoplasm/cancer; novel; oncology; pilot study; polymorphism; pre-clinical; preclinical; preclinical study; relational database; repository; research study; study design; tumor; volunteer",CLINICAL PHARMACOLOGY SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,148262
8015001,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5676,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"GIVAN, ALICE L.;",2432084;,5P30CA023108,,,"3-D; 3-Dimensional; Analysis, Data; Ar element; Argon; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blood leukocyte; Body Tissues; CCSG; Ca++ element; Calcium; Calibration; Cancer Center; Cancer Center Support Grant; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Collaborations; Color; Comb animal structure; Combs; Communication; Computer Programs; Computer software; Computers; Consult; Core Grant; Cotton Plant; Cytofluorometry, Flow; Data; Data Analyses; Development; Documentation; Electromagnetic, Laser; Elements; Equipment; Factor IV; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Foundations; Funding; Future; Goals; Gossypium; Grant; Hour; IMPHENO; Image; Image Analyses; Image Analysis; Immunophenotyping; Individual; Instrumentation, Other; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; Laboratories; Lasers; Leukocytes; Marrow leukocyte; Measures; Methods; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Microscope; Mission; Monitor; NCRR; National Center for Research Resources; P30 Grant; Pattern; Preparation; Programs (PT); Programs [Publication Type]; Quality Control; ROC Analysis; Radiation, Laser; Research; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Reticuloendothelial System, Leukocytes; Running; SCHED; Scanning; Schedule; Schools, Medical; Scientist; Services; Side; Signal Transduction; Signal Transduction Systems; Signaling; Software; Sorting - Cell Movement; Speed; Speed (motion); Staging; Students; Subcellular Process; Subtyping, Immunologic; Subtypings, Immunologic; Survey Instrument; Surveys; System; System, LOINC Axis 4; Techniques; Technology; Temperature; Time; Tissues; Training; UV laboratory microscope; Ultraviolet Microscopes; White Blood Cells; White Cell; Work; assay development; biological signal transduction; cell imaging; cellular imaging; computer imaging; computer program/software; cotton; detector; digital imaging; flow cytophotometry; fluorescence microscope; fluorescence/UV microscope; fluorescent microscope; image evaluation; imaging; immunophenotype; instrument; instrumentation; interest; laboratory fluorescence light microscope; medical schools; programs; reconstruction; sorting; ward; white blood cell; white blood corpuscle",FLOW CYTOMETRY AND CELL IMAGING SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,118719
8015002,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5679,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"TOMLINSON, CRAIG R;",1869092;,5P30CA023108,,,"Arts; Bio-Informatics; Bioinformatics; Biological Function; Biological Process; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; CCSG; Cancer Center Support Grant; Communities; Consultations; Core Facility; Core Grant; CpG Islands; CpG-Rich Islands; Data; Experimental Designs; Freezing; Gene Action Regulation; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Transcription; Genetic Transcription; Genome; Genomics; Genomics Shared Resource; Goals; Heterogeneous Nuclear RNA; Investigators; Knowledge; Laboratories; Micro RNA; MicroRNAs; Nuclear; P30 Grant; Polyribosomes; Polysomes; Pre-mRNA; Process; Profilings, Gene Expression; RNA; RNA Expression; RNA analysis; RNA, Non-Polyadenylated; Research; Research Personnel; Research Resources; Researchers; Resources; Ribonucleic Acid; Sampling; Services; Structure; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription, Genetic; anticancer research; cancer research; cost; high throughput technology; hnRNA; meetings; member; miRNA; new technology; statistics/biometry; web site",GENOMICS SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,113940
8015003,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5681,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"CHANNON SMITH, JACQUELINE YVONNE;",8542272;,5P30CA023108,,,"ATGN; Aliquot; Antibodies; Antigens; Antineoplastic Vaccine; Apoptosis; Apoptosis Pathway; Arts; Assay; B-Cell Subsets; B-Lymphocyte Subsets; Bioassay; Biologic Assays; Biological; Biological Assay; Blood; Blood Plasma; Blood Serum; Blood leukocyte; Bone-Derived Transforming Growth Factor; Budgets; CCSG; CD8; CD8B; CD8B1; CD8B1 gene; COBRE; Cancer Center Support Grant; Cancer Vaccines; Cell Count; Cell Culture Techniques; Cell Death, Programmed; Cell Number; Cells; Center of Biomedical Research Excellence; Centers of Research Excellence; Charge; Clinical Trials; Clinical Trials, Unspecified; Color; Communities; Compensation; Computer Programs; Computer software; Core Grant; Cryofixation; Cryopreservation; Cryopreserved Cell; Cytofluorometry, Flow; DMSO; Demasorb; Demeso; Dendritic Cells; Detection; Dimethyl Sulfoxide; Dimethylsulphinyl; Dimethylsulphoxide; Domoso; Dromisol; ELISPOT; Enrollment; Fees; Financial compensation; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Fluorochrome; Frequencies (time pattern); Frequency; Goiaba; Graph; Guava; Guava Fruit; Harvest; Hour; Housing; Human; Human, General; INFLM; ITX; Immune response; Immunoassay; Immunologic Monitoring; Immunologically Directed Therapy; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosurveillance; Immunotherapy; In Vitro; Incubated; Individual; Inflammation; Investigators; LYT3; Label; Laboratories; Leukocytes; Longitudinal Studies; Man (Taxonomy); Man, Modern; Marrow leukocyte; Measurement; Measures; Mediation; Method LOINC Axis 6; Methodology; Microbiology; Microfluorometry, Flow; Milk Growth Factor; Monitor; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; Negotiating; Negotiation; Neurology; P30 Grant; PBMC; Patients; Peptides; Peripheral Blood Mononuclear Cell; Phenotype; Plasma; Platelet Transforming Growth Factor; Population; Process; Programs (PT); Programs [Publication Type]; Proliferating; Pump; Quality Control; Reader; Reading; Regulatory T-Lymphocyte; Reproducibility of Findings; Reproducibility of Results; Research; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Serum, Plasma; Running; SEB; Sampling; Schools, Medical; Science of Microbiology; Serum; Serum, Plasma; Services; Software; Staining method; Stainings; Stains; Standardization; Staphylococcal Enterotoxin B; Stimulus; Sulfinylbis(methane); Surface; Syringes; T memory cell; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; TGF B; TGF-beta; TGFbeta; Testing; Thymus-Dependent Lymphocytes; Time; Training; Transforming Growth Factor beta; Tube; Vaccines, Neoplasm; Vaccines, Tumor; Validation; Veiled Cells; WHBLOOD; White Blood Cells; White Cell; Whole Blood; base; cell separator; clinical investigation; cold preservation; cold storage; computer program/software; cost; cytokine; cytotoxic serine protease B; design; designing; detector; discount; enroll; enzyme linked immunospot assay; flow cytophotometry; fragmentin 2; granzyme B; host response; immune therapy; immunogen; immunoresponse; instrument; long-term study; magnetic beads; medical schools; member; memory T lymphocyte; programs; quality assurance; response; staph enterotoxin B; thymus derived lymphocyte; uptake; white blood cell; white blood corpuscle",IMMUNE MONITORING SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,158769
8015004,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5682,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"HOOPES, P. JACK ;",6520233;,5P30CA023108,,,"Animal Experiments; Animals; Antineoplastic Vaccine; Budgets; CCSG; Cancer Center Support Grant; Cancer Vaccines; Cancers; Cardiac; Cell Culture Techniques; Cell Survival; Cell Viability; Cells; Center Core Grants; Cesium; Clinical; Clinical Trials; Clinical Trials, Unspecified; Communities; Core Grant; Cs element; Development; Dose-Rate; Electromagnetic Radiation, Ionizing; Electrons; Experiments, Animal; Fee-for-Service Plans; Feedback; Fees; Fees for Service; Goals; Hour; Image; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Individual; Institution; Investigators; Ionizing radiation; Irradiation Shared Resource; Laboratories; Linear Accelerator; Linear Accelerator Radiotherapy Systems; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Rodents; Mission; Natural immunosuppression; Negative Beta Particle; Negatrons; Normal Tissue; Normal tissue morphology; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; P30 Grant; P30 Mechanism; P30 Program; Patients; Photons; Radiation; Radiation Surgery; Radiation-Ionizing Total; Radiosurgery; Radiotherapy Systems, Linear Accelerator; Relative; Relative (related person); Research; Research Personnel; Research Resources; Researchers; Resources; Respiration; Rodent; Rodentia; Rodentias; Services; Source; Stereotactic External Beam Irradiation; Stereotactic Radiosurgery; Stereotaxic Radiosurgery; Tube; Tumor Cell; Vaccines, Neoplasm; Vaccines, Tumor; base; clinical investigation; cone-beam computed tomography; cost; experiment; experimental research; experimental study; flasks; imaging; immunosuppression; instrument; irradiation; malignancy; meetings; neoplasm/cancer; neoplastic cell; ray (radiation); research study; respiratory mechanism; tumor",IRRADIATION SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,95604
8015005,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5685,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"SANCHEZ, YOLANDA ;",1879838;,5P30CA023108,,,"Analysis, Data; Archives; Arts; Assay; Base Sequence; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biology; Biostatistics Shared Resource; Books; Budgets; Buffers; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Patient; Center Core Grants; Charge; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Client; Communities; Computer Programs; Computer Systems Development; Computer software; Computers; Core Facility; Core Grant; DNA; DNA Molecular Biology; DNA Sequence; DNA analysis; Data; Data Analyses; Deoxyribonucleic Acid; Detection; Development, Computer Systems; Diagnosis; Fees; Future; Gel; Gene Products, RNA; Genetic Polymorphism; Genome; Genomics; Genotype; Goals; HPLC; High Pressure Liquid Chromatography; Image; Individual; Instrumentation, Other; Investigators; Laboratories; Laboratory Research; Lead; Lebanon; Length; Mails; Maintenance; Maintenances; Manufacturer; Manufacturer Name; Membrane; Methylation; Molecular Biology; Molecular Biology Shared Resource; Molecular Biology, Nucleic Acid Sequencing; Molecular Biology, Restriction Fragment Length Polymorphisms; Molecular Dynamics Simulation; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; Nucleic acid sequencing; Nucleotide Sequence; Oligo; Oligonucleotides; P30 Grant; P30 Mechanism; P30 Program; Pb element; Polymers; Polymorphism (Genetics); Polymorphism, Genetic; Price; Procedures; Process; Protein Methylation; Proteomics; Proteomics Shared Resource; RFLP; RNA; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Radiographic Film; Reaction; Reading; Reagent; Records; Research; Research Personnel; Research Resources; Research, Laboratory; Researchers; Resource Sharing; Resources; Restriction fragment length polymorphism; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Robotics; Running; SEQ-AN; Sampling; Savings; Sequence Analyses; Sequence Analysis; Services; Side; Software; Source; System; System, LOINC Axis 4; Systems Development; Technology; Time; Universities; X-Ray Film; Xray Film; anticancer research; base; cancer research; computer imaging; computer program/software; cost; digital imaging; discount; heavy metal Pb; heavy metal lead; high throughput analysis; imaging; instrument; instrumentation; mRNA Expression; macromolecule; meetings; member; membrane structure; migration; molecular dynamics; nucleic acid sequence; polymorphism; pricing; reverse transcriptase PCR; systems research; tool",MOLECULAR BIOLOGY SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,71332
8015006,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5686,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"RHODES, CHARLES HARKER;",1899861;,5P30CA023108,,,"Apheresis; Autologous; Biological Preservation; Blood Component Removal; Blood leukocyte; Body Tissues; CCSG; Cancer Center Support Grant; Categories; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Clinical Research; Clinical Study; Computers; Core Grant; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Services; Diagnostic Technique; Funding; Hemapheresis; Histologic; Histologically; Histology; Investigators; Laboratories; Leukocytes; Marrow leukocyte; Method LOINC Axis 6; Methodology; Molecular; Operation; Operative Procedures; Operative Surgical Procedures; P30 Grant; Pathologist; Pathology; Patients; Pheresis; Preservation, Biologic; Preservation, Biological; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Research; Research Activity; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resource Sharing; Resources; Reticuloendothelial System, Leukocytes; Services; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Time; Tissues; Translating; Translatings; White Blood Cells; White Cell; Work; Writing; clinical data repository; clinical data warehouse; data repository; diagnosis service; falls; human tissue; language translation; laser capture microdissection; member; molecular pathology; peripheral blood; preservation; relational database; surgery; vaccine development; volunteer; white blood cell; white blood corpuscle",PATHOLOGY SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,95637
8015007,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5687,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"GERBER, SCOTT A.;",8579458;,5P30CA023108,,,"Acetylation; Address; Administrator; Ag element; Alkylation; Amino Acid Sequence; Analysis, Cost; Analysis, Data; Archives; Area; Arts; Back; Bar Codes; Bioinformatics Shared Resource; Biology; Bite; Businesses; CCSG; Cancer Center; Cancer Center Support Grant; Charge; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Client; Code; Codes, Bar; Coding System; Commit; Communities; Complex Mixtures; Computer Assisted; Computer Programs; Computer software; Computers; Consult; Consultations; Core Facility; Core Grant; Cost Analyses; Cost Analysis; Cost Savings; DNA; DNA Molecular Biology; Data; Data Analyses; Data Banks; Data Bases; Data Files; Data Reporting; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Digestion; Dorsum; Drops; E-Mail; Electronic Mail; Electronics; Electrophoresis; Email; Ensure; Equipment; Experimental Designs; Faculty; Feedback; Files, Data; Foundations; Fractionation, Electrophoretic; Funding; Future; Gel; Generalized Growth; Grant; Growth; HPLC; High Pressure Liquid Chromatography; Hour; Housing; Immune Precipitation; Immunoprecipitation; Individual; Institution; Instrumentation, Other; Investigators; Ions; LC/MS; Laboratories; Laboratory Research; MALD-MS; MALDI; MALDI-MS; Maintenance; Maintenances; Manuals; Mass Spectrum; Mass Spectrum Analysis; Methods; Methylation; Mission; Modification; Molecular Biology; Molecular Biology, Protein Sequencing; Molecular Weight; Names; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; Operation; Operative Procedures; Operative Surgical Procedures; P30 Grant; Peptide Sequence Determination; Peptides; Phase Transition; Phosphorylation; Photometry/Spectrum Analysis, Mass; Post Translational Modification Analysis; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Price; Process; Protein Analysis; Protein Cleavage; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Sequencing; Protein Structure, Primary; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteolysis; Proteomics; Proteomics Shared Resource; Protocol; Protocols documentation; Pump; Recruitment Activity; Reporting; Reporting, Data; Research; Research Personnel; Research Resources; Research, Laboratory; Researchers; Resource Sharing; Resources; Running; Sampling; Saving, Cost; Schools, Medical; Security; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Services; Silver; Silver Staining; Site; Software; Solvents; Source; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Staging System; Staining method; Stainings; Stains; Structure; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Technology; Time; Tissue Growth; Training; Tripcellim; Trypsin; Update; Validation; Writing; base; chemical synthesis; clinical data repository; clinical data warehouse; cluster computing; computational grid; computer aided; computer program/software; computing resources; cost; data acquisition; data grid; data integrity; data repository; datagrid; design; designing; detector; distributed computing; e-science; encryption; escience; experiment; experimental research; experimental study; falls; federated computing; federated data; federated database; firewall; functional group; gene product; grid computing; instrument; instrumentation; interest; liquid chromatography mass spectrometry; mass spectrometer; matrix assisted laser desorption ionization; medical schools; meetings; member; ontogeny; parallel processing; pricing; protein complex; protein sequence; recruit; relational database; research study; silver impregnation; skills; small molecule; surgery; trafficking; web site",PROTEOMICS SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,65333
8015008,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5688,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"FIERING, STEVEN ;",1916115;,5P30CA023108,,,"Agreement; Animals, Genetically Modified; Area; Arts; Basic Cancer Research; Blotting, Southern; CCSG; Cancer Center; Cancer Center Support Grant; Chimera; Chimera organism; Collaborations; Communication; Consultations; Cooperative Agreements; Cooperative Agreements, U-Series; Core Grant; Cotton Plant; Cryofixation; Cryopreservation; DNA; DNA Molecular Biology; DNA blotting; Deoxyribonucleic Acid; E coli; ES cell; Embryo; Embryonic; Escherichia coli; Experimental Models; Experimental Models, Other; Funding; GMO Animals; Gene Targeting; Generations; Genetic; Genetic Services; Genetically Modified Animals; Genetics, Karyotyping; Genotype; Gossypium; Grant; Home; Home environment; Housing; Inbred Strains Mice; Individual; Injection of therapeutic agent; Injections; Investigators; Karyotype determination procedure; Karyotyping; Knock-out; Knockout; Knockout Mice; Laboratories; Mammals, Mice; Mice; Mice, Inbred Strains; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Microinjections; Models, Experimental; Molecular; Molecular Biology; Mouse Strains; Movement; Murine; Mus; Mutant Strains Mice; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; P30 Grant; Preclinical Testing; Price; Principal Investigator; Production; Reagent; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Services; Southern Blotting; Sperm; Spermatozoa; Surgical; Surgical Interventions; Surgical Procedure; Targetings, Gene; Technology; Transfection; Transgenic Mice; Transgenic Organisms; U-Series Cooperative Agreements; Yeasts; body movement; cold preservation; cold storage; cotton; design; designing; embryonic stem cell; experience; genetic manipulation; member; mouse model; mouse mutant; novel; offspring; pathogen; pricing; sperm cell; stem cell of embryonic origin; surgery; transgenic; zoosperm",TRANSGENICS AND GENETIC CONSTRUCTS SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,90773
8015009,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5689,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"MOORE, JASON H.;",6360445;,5P30CA023108,,,"Acer; Analysis, Data; Architecture; Arts; Bio-Informatics; Bioconductor; Bioinformatics; Bioinformatics Shared Resource; Biology; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; CCSG; Cancer Center; Cancer Center Support Grant; Cancers; Clinical Data; Cluster Analyses; Cluster Analysis; Communities; Computer Analysis; Computer Programs; Computer Programs and Programming; Computer Software Development; Computer Software Engineering; Computer Software Tools; Computer Systems; Computer software; Computers; Core Facility; Core Grant; Cost Savings; Cotton Plant; DNA Molecular Biology; Data; Data Analyses; Data Banks; Data Bases; Data Display; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Designing computer software; Development; Engineering / Architecture; Engineering, Software; Faculty; Genetic analyses; Genomics; Goals; Gossypium; High Performance Computing; Human Resources; Ice; Imagery; Individual; Infrastructure; Investigators; Java; Language; Lead; Leadership; Learning, Machine; Libraries; Licensing; Linux; Machine Learning; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Manpower; Maple; Molecular Biology; Network Analysis; Operating System; Oranges; P30 Grant; Pathway Analysis; Pathway interactions; Pb element; Performance Computing, High; Play; Price; Program Development; Programs (PT); Programs [Publication Type]; Proteomics; Pythons; Quality Control; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Retrieval; Role; Running; Saving, Cost; Services; Site; Software; Software Design; Software Engineering; Software Tools; Solutions; System; System, LOINC Axis 4; Technology; Tools, Software; Training; Visual; Visualization; anticancer research; caBIG; cancer Biomedical Informatics Grid; cancer research; clinical data repository; clinical data warehouse; computational analysis; computational tools; computer program; computer program/software; computer programming; computerized tools; cost; cotton; data mining; data repository; database design; datamining; design; designing; experience; genetic analysis; heavy metal Pb; heavy metal lead; kernel methods; malignancy; meetings; member; neoplasm/cancer; open source; parallel computer; pathway; personnel; pricing; programs; relational database; social role; statistical learning; statistics/biometry; support vector machine; tool",BIOINFORMATICS SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,99338
8015010,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5690,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"TOSTESON, TOR D.;",1918025;,5P30CA023108,,,"Analysis, Data; Area; Bioinformatics Shared Resource; Biology; Biostatistics Shared Resource; CCSG; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Science; Clinical; Clinical Data; Clinical Protocols; Clinical Research; Clinical Study; Clinical Trial Protocol; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Monitoring; Clinical Trials, Unspecified; Clinical trial protocol document; Collaborations; Computer Programs; Computer software; Consultations; Core Grant; Cost Effective Analyses; Cost Effectiveness Analysis; Data; Data Analyses; Data Monitoring Committees; Data and Safety Monitoring Boards; Decision Modeling; Development; Diagnostic tests; Education; Educational aspects; Educational workshop; Epidemiology; Experimental Designs; Faculty; Funding; Genomics; Goals; Grant; IT Systems; Image; Informatics; Information Systems; Information Technology; Information Technology Systems; Investigators; Laboratories; Leadership; Manuscripts; Measurement; Method LOINC Axis 6; Methodology; Methods; Modeling, Decision; Monitor; Monitoring Clinical Trials; P30 Grant; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; Randomized; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Proposals; Research Resources; Researchers; Resources; SCHED; Safety; Safety Monitoring Boards; Sample Size; Schedule; Scientific Publication; Services; Software; Sound; Sound - physical agent; Specialist; Statistical Methods; Study Type; Study of epidemiology; Systems, Data; Technology; Time; Translational Research; Translational Research Enterprise; Translational Science; Workshop; anticancer research; base; cancer research; clinical investigation; computer program/software; cost efficient analysis; data management; design; designing; epidemiology study; imaging; meetings; member; novel; programs; protocol development; randomisation; randomization; randomly assigned; sound; study design; translation research enterprise",BIOSTATISTICS SHARED RESOURCE,,23108,NCI,Subcommittee E - Prevention & Control,,32,,191994
8015011,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5691,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"PIPAS, JAMES M;",1876591;,5P30CA023108,,,"Active Follow-up; Address; Adherence; Adherence (attribute); Adverse Experience; Adverse event; Agreement; Award; Breast; Budgets; CCSG; Calendar; Cancer Center; Cancer Center Support Grant; Case Report Form; CaseReportForm; Clinical; Clinical Oncology; Clinical Protocols; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Database; Clinical Trials, Monitoring; Clinical Trials, Therapy; Clinical Trials, Unspecified; Collaborations; Compliance, Protocol; Conduct Clinical Trials; Consent; Consent Documents; Consent Forms; Contracting Opportunities; Contracts; Core Grant; Cotton Plant; Data; Data Banks; Data Bases; Data Collection; Data Monitoring Committees; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Disease; Disease by Site; Disorder; Disorder by Site; Documentation; Drugs; Drugs, Investigational; ELIG; Education; Educational aspects; Eligibility; Eligibility Determination; Enrollment; Ensure; Ethics Committees, Research; Evaluation; Funding; Genital System, Male, Prostate; Gossypium; Grant; Gynecologic Oncology; Head and Neck; Head and neck structure; Health system; Hospitals, Rural; Housing; Human Prostate; Human Prostate Gland; IRBs; Informed Consent; Informed Consent Documents; Informed Consent Forms; Institutional Review Boards; Intervention Trial; Investigational Drugs; Investigational New Drugs; Investigators; Lung; Maintenance; Maintenances; Malignant Melanoma; Medical Directors; Medical center; Medication; Monitor; Monitoring Clinical Trials; New England; Northeastern United States; Nursing Research; Oncology Group; Operation; Operative Procedures; Operative Surgical Procedures; P30 Grant; Patients; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacies; Pharmacists; Pharmacy facility; Physician Executives; Policies; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; Protocol; Protocol Compliance; Protocol Screening; Protocols documentation; Records; Recruitment Activity; Regulation; Reporting; Research; Research Contracts; Research Ethics Committees; Research Personnel; Research Resources; Research Support; Researchers; Resources; Respiratory System, Lung; Rural Hospitals; Safety; Safety Monitoring Boards; Schools, Medical; Screening procedure; Services; Site; Specialist; Standardization; Supervision; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Technology; Therapeutic Trials; Therapy Clinical Trials; Training; Training Support; Update; Work; Writing; anticancer research; base; cancer research; clinical data repository; clinical data warehouse; clinical investigation; computerized; cotton; data management; data repository; disease/disorder; drug/agent; enroll; follow-up; human subject; leukemia/lymphoma; lymphoma/leukemia; medical schools; meetings; melanoma; member; programs; protocol development; pulmonary; quality assurance; recruit; relational database; screening; screenings; surgery; tumor registry; working group",OFFICE OF CLINICAL RESEARCH,,23108,NCI,Subcommittee E - Prevention & Control,,32,,195658
8015012,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5692,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"LEWIS, LIONEL DAVID;",6793950;,5P30CA023108,,,"Address; Amendment; Area; Benefits and Risks; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Budgets; CCSG; Cancer Center Support Grant; Cancer Patient; Cancers; Clinical; Clinical Oncology; Clinical Practice Guideline; Clinical Practice Guidelines; Clinical Research; Clinical Study; Clinical Trial Protocol; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Unspecified; Clinical trial protocol document; Committee Members; Conflict of Interest; Core Grant; Data; Data Monitoring Committees; Data and Safety Monitoring Boards; Development; Disease; Disease by Site; Disorder; Disorder by Site; Ensure; Ethics Committees, Research; Frequencies (time pattern); Frequency; Funding Agency; Funding Source; IRBs; Informed Consent; Institutional Review Boards; Investigators; Left; Letters; Life; Malignant Neoplasms; Malignant Tumor; Mediation; Medical; Medical Directors; Members, Committee; Monitor; Negotiating; Negotiation; Norris Cotton Cancer Center; Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center; Oncology Group; P30 Grant; Patients; Persons; Phase; Physician Executives; Preparation; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; Recruitment Activity; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Review Committee; Rights; Risk; SCHED; Safety; Safety Monitoring Boards; Schedule; Scientific Publication; System; System, LOINC Axis 4; Voting; Voting Right; Writing; anticancer research; base; cancer prevention; cancer research; clinical investigation; college; cooperative study; data integrity; design; designing; disease/disorder; falls; human subject; human subject protection; malignancy; meetings; member; neoplasm/cancer; patient population; programs; recruit; statistics/biometry; tumor registry; working group",PROTOCOL REVIEW AND MONITORING SYSTEM,,23108,NCI,Subcommittee E - Prevention & Control,,32,,45396
8015013,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5693,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"PEREZ, RAYMOND P;",1871801;,5P30CA023108,,,"Address; Adverse Experience; Adverse event; Award; CCSG; Cancer Center; Cancer Center Support Grant; Clinical Data; Clinical Protocols; Clinical Research; Clinical Study; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase I; Collection; Communication; Core Grant; Data; Data Banks; Data Bases; Data Monitoring Committees; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease; Disorder; Documentation; ELIG; Early-Stage Clinical Trials; Eligibility; Eligibility Determination; Enrollment; Ethics; Funding; Human Resources; Informed Consent; Investigators; Learning; Maintenance; Maintenances; Manpower; Monitor; Nursing Research; P30 Grant; Patient Participation; Patient Recruitments; Patient Schedules; Patients; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Principal Investigator; Protocol; Protocol Screening; Protocols documentation; R01 Mechanism; R01 Program; RPG; Recruitments, Patient; Reporting; Research; Research Grants; Research Personnel; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Support; Research Training; Researchers; Resources; Safety; Safety Monitoring Boards; Testing; Visit; Work; base; clinical data repository; clinical data warehouse; computerized; data repository; disease/disorder; enroll; experience; novel; personnel; phase 1 study; phase 1 trial; phase I trial; protocol, phase I; quality assurance; relational database",PROTOCOL-SPECIFIC RESEARCH SUPPORT,,23108,NCI,Subcommittee E - Prevention & Control,,32,,125362
8015014,P30,CA,5,,12/01/2009,11/30/2010,,5P30CA023108-32,5694,,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"PEREZ, RAYMOND P;",1871801;,5P30CA023108,,,"Address; Adverse Experience; Adverse event; Biologic Products; Biological Agent; Biological Products; CCSG; Cancer Center; Cancer Center Support Grant; Chair; Chairman; Chairperson; Chairwoman; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase III; Clinical Trials, Unspecified; Conduct Clinical Trials; Core Grant; Cotton Plant; Data; Data Monitoring Committees; Data and Safety Monitoring Boards; Devices; Drugs; Enrollment; Ensure; Ethics Committees, Research; Frequencies (time pattern); Frequency; Gossypium; Grant; Guidelines; IRBs; Individual; Institutional Review Boards; Investigators; Medical center; Medication; Monitor; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; P30 Grant; Participant; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Principal Investigator; Procedures; Protocol; Protocols documentation; Publishing; Randomized; Reporting; Research Design; Research Ethics Committees; Research Personnel; Researchers; Risk; SAE; Safety; Safety Monitoring Boards; Serious Adverse Event; Severities; Specific qualifier value; Specified; Structure; Study Subject; Study Type; Support Contracts; System; System, LOINC Axis 4; Time; Toxic effect; Toxicities; United States National Institutes of Health; anticancer research; authority; base; biopharmaceutical; biotherapeutic agent; cancer research; clinical investigation; cotton; design; designing; drug/agent; empowered; enroll; handbook; high risk; human subject protection; meetings; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; patient safety; phase 2 study; phase 3 study; phase 3 trial; phase III trial; protocol, phase III; randomisation; randomization; randomly assigned; study design; study, phase III",DATA AND SAFETY MONITORING,,23108,NCI,Subcommittee E - Prevention & Control,,32,,28465
7746450,P30,DK,5,,01/01/2010,12/31/2010,DK-04-014,5P30DK043351-20,,NIDDK:1312500;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"XAVIER, RAMNIK J;",2088086;,5P30DK043351,01/01/1997,12/31/2010,,Center for the Study of Inflammatory Bowel Disease,,43351,ZDK1,Special Emphasis Panel,,20,1312500,
8017399,P30,DK,5,,01/01/2010,12/31/2010,,5P30DK043351-20,9001,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"PODOLSKY, DANIEL K;",7007474;,5P30DK043351,,,"Adoption; Animals; Area; Bio-Informatics; Bioinformatics; Biological; Biology; Blastocyst; Blastocyst structure; Blastosphere; Body Tissues; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; Cell-to-Cell Interaction; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chromosomes; Cloning; Collaborations; Communities; Complementary DNA; Computer Programs; Computer Software Tools; Computer software; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA Molecular Biology; DNA Polymerases; DNA Recombination; DNA Sequence; DNA recombination (naturally occurring); DNA, Complementary; DNA-Dependent DNA Polymerases; DNA-Dependent RNA Polymerase III; DNA-Directed DNA Polymerase; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dendritic Cells; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Development; EC 2.7.7.7; ES cell; Economics; Education; Educational aspects; Embryo, Preimplantation; Epithelial; Epithelial Cells; Evaluation; Foundations; Funding; Gastroenterology; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Products, RNA; Gene Proteins; Gene Targeting; Generations; Genes; Genes, Regulator; Genes, Reporter; Genetic Recombination; Genetic analyses; Genetics, Human; Genetics-Mutagenesis; Genomics; Goals; HOSP; Haplotypes; Hospitals; Human; Human Genetics; Human, General; Hybrids; IFN; Immune; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Individual; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Injection of therapeutic agent; Injections; Injury; Institution; Interferons; Internet; Interphase Cell; Intracellular Communication and Signaling; Intranet; Investigators; Israel; Knock-in; Knock-in Mouse; Knock-out; Knockout; Laboratories; Lentiviral Vector; Lentivirus Vector; Libraries; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Massachusetts; Medical center; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Modeling; Modification; Molecular; Molecular Biology; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Murine; Mus; Mutagenesis; Natural Immunity; New England; Non-dividing Cell; Northeastern United States; Nucleotides; Oligo; Oligonucleotide Probes; Oligonucleotides; Outcome; Pathogenesis; Physiologic; Physiological; Plasmids; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postdoc; Postdoctoral Fellow; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Preparation; Process; Production; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Gene Products; Proteins; Quelling; R01 Mechanism; R01 Program; RNA; RNA Interference; RNA Polymerase C; RNA Polymerase III; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Small Interfering; RNAi; RPG; Reagent; Recombinants; Recombination; Recombination, Genetic; Regulator Genes; Reporter Genes; Research; Research Associate; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Resting Cell; Ribonucleic Acid; Role; Schools, Medical; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Services; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Software; Software Tools; Speed; Speed (motion); Spinal Column; Spine; Students; Subcellular Process; System; System, LOINC Axis 4; Targetings, Gene; Techniques; Technology; Technology Transfer; Time; Tissues; Tools, Software; Training; Training Programs; Training Support; Transcript Expression Analyses; Transcript Expression Analysis; Transcriptional Regulatory Elements; Transfection; Transgenic Mice; Transgenic Organisms; Universities; Veiled Cells; Vertebral column; Viral Vector; WWW; Woman; Work; analytical method; backbone; base; biological signal transduction; blastocyst; blastula; cDNA; cell biology; clinical data repository; clinical data warehouse; computer program/software; cost; cost effective; cultured cell line; data repository; design; designing; embryonic stem cell; expression cloning; expression vector; flexibility; gene product; genetic analysis; genetic manipulation; in vivo; insight; interest; mRNA; medical schools; member; microarray technology; microbial interaction; microorganism interaction; new technology; post-doc; post-doctoral; programs; protein expression; regulatory gene; relational database; repository; screening; screenings; shRNA; short hairpin RNA; siRNA; small hairpin RNA; social role; stem cell of embryonic origin; tool; trans acting element; transgenic; vector; vector control; web; world wide web",Molecular Biology Core,,43351,ZDK1,Special Emphasis Panel,,20,,345176
8017400,P30,DK,5,,01/01/2010,12/31/2010,,5P30DK043351-20,9002,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"PODOLSKY, DANIEL K;",7007474;,5P30DK043351,,,"Alimentary Canal; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Area; Arts; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Biopsy; Body Tissues; Cell Death, Programmed; Cells; Cellular Morphology; Complement; Complement Proteins; Computer Programs; Computer software; Confocal Microscopy; Core Facility; Coupled; Digestive Tract; Disease; Disorder; Electromagnetic, Laser; Electron Microscope; Electrons; Epithelial; Epithelial Cells; Epithelium; Equipment; Evaluation; Event; Expertise, Technical; Faculty; Freeze Sectioning; Frozen Sections; Funding; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Genetic; Goals; Grant; Human Resources; Image; Image Analyses; Image Analysis; Imaging technology; Immune response; Immunoperoxidase Technics; Individual; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intestinal; Intestinal Diseases; Intestinal Disorder; Intestines; Investigators; Laboratory Personnel; Lamina Propria; Lasers; Lead; Life; Light; Lymphocyte; Lymphocytic; Mammals, Mice; Manpower; Marshal; Membrane; Methods; Methods and Techniques; Methods, Other; Mice; Microscope; Microscopic; Microscopy, Confocal; Moab, Clinical Treatment; Modeling; Modification; Monoclonal Antibodies; Morphology; Mucosal Inflammation; Mucositis; Murine; Mus; NCRR; National Center for Research Resources; Negative Beta Particle; Negatrons; Pathogenesis; Pb element; Photoradiation; Procedures; Proteins; ROC Analysis; Radiation, Laser; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Services; Software; Specimen; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Staining method; Stainings; Stains; System; System, LOINC Axis 4; Technical Expertise; Techniques; Techniques, Immunoperoxidase; Technology; Time; Tissues; UV laboratory microscope; Ultraviolet Microscopes; Update; VESCL; Vesicle; Work; alimentary tract; bowel; cell imaging; cell morphology; cellular imaging; computer imaging; computer program/software; digestive canal; digital; digital imaging; disease/disorder; epon; experiment; experimental research; experimental study; fluorescence microscope; fluorescence/UV microscope; fluorescent microscope; gene product; heavy metal Pb; heavy metal lead; host response; image evaluation; imaging; immunoperoxidase; immunoresponse; insight; intestine disorder; laboratory fluorescence light microscope; lymph cell; membrane structure; model organism; new technology; personnel; polarized cell; research study; response; skills; success",Morphology Core,,43351,ZDK1,Special Emphasis Panel,,20,,345175
8017401,P30,DK,5,,01/01/2010,12/31/2010,,5P30DK043351-20,9004,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"PODOLSKY, DANIEL K;",7007474;,5P30DK043351,,,"Address; Adoptive Transfer; Alimentary Canal; Animal Genetics; Animal Model; Animal Models and Related Studies; Animals; Area; Bone Marrow; Breeding; Chronic; Colitis; Complex; DNA Alteration; DNA mutation; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Derivation; Derivation procedure; Development; Digestive Tract; Disease; Disorder; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Alteration; Gene Expression; Gene Mutation; Genetic; Genetic mutation; Gnotobiotic; Gnotobiotics; Goals; Gut Inflammation; Immune system; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Diseases of the Intestinal Tract; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Intestinal Inflammation; Intestinal Mucosa; Investigators; Lead; Lymphocyte; Lymphocyte Subpopulations; Lymphocyte Subset; Lymphocytic; Maintenance; Maintenances; Mammals, Mice; Mice; Mice, Mutant Strains; Modeling; Murine; Mus; Mutant Strains Mice; Pathogenesis; Pathway interactions; Pb element; Play; Process; Production; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Sequence Alteration; Services; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; Transgenic Organisms; alimentary tract; body system, allergic/immunologic; clinical data repository; clinical data warehouse; data repository; digestive canal; disease/disorder; enteritis; experiment; experimental research; experimental study; germ free condition; heavy metal Pb; heavy metal lead; interest; lymph cell; member; model development; model organism; mouse mutant; organ system, allergic/immunologic; pathway; relational database; research study; sample collection; social role; specific pathogen free; specimen collection; thymus derived lymphocyte; transgenic",Genetic Animal Core,,43351,ZDK1,Special Emphasis Panel,,20,,383308
8017402,P30,DK,5,,01/01/2010,12/31/2010,,5P30DK043351-20,9005,,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"PODOLSKY, DANIEL K;",7007474;,5P30DK043351,,,"Affect; Banking, Tissue; Biochemical; Blood; Blood Serum; Body Tissues; Clinical; Clinical Investigator; Clinical Research; Clinical Study; Collaborations; DNA; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Disease; Disease Marker; Disorder; Epidemiology, Family Medical History; Equipment and supply inventories; Family Medical History; Family history of; Genetic; Goals; HCV infection; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inventory; Investigators; Laboratories; Link; Molecular; NANBH; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patient Care; Patient Care Delivery; Patients; Play; Protocol; Protocols documentation; Reagent; Reference Standards; Research; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Reticuloendothelial System, Blood; Role; Sampling; Serum; Specimen; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Tissues; base; clinical data repository; clinical data warehouse; data repository; disease/disorder; hepatitis non A non B; hepatitis nonA nonB; kindred; meetings; member; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; relational database; repository; social role; success",Clinical Tissue Core,,43351,ZDK1,Special Emphasis Panel,,20,,238841
7762780,P30,MH,5,,02/01/2010,01/31/2011,PAR-03-142,5P30MH043520-22,,NIMH:1985039;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"EHRHARDT, ANKE A;",1876860;,5P30MH043520,02/01/1997,01/31/2013,,HIV Center for Clinical and Behavior Studies,,43520,ZMH1,Special Emphasis Panel,,22,1985039,
8015615,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9002,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"MEYER-BAHLBURG, HEINO ;",6102297;,5P30MH043520,,,"AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adaptation, Psychologic; Adaptation, Psychological; Affect; Anti-Retroviral Agents; Antiretroviral Agents; Area; Attitude; Awareness; Awarenesses; Behavior; Behavioral Research; Behavioral Sciences; Caring; Clinical; Collaborations; Communities; Conceptions; Consultations; Country; Data; Development; Discipline; Doctor of Philosophy; Drug Formulations; Educational workshop; Ethnography; Formulation; Formulations, Drug; Gender; Gender Identity; HIV; HIV Prevention; HIV test; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; Health behavior; Hour; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Individual; Interdisciplinary Research; Interdisciplinary Study; Intervention; Intervention Strategies; Interview; Investigation; Investigators; LAV-HTLV-III; Lead; Life; Lymphadenopathy-Associated Virus; Maps; Mediating; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Method LOINC Axis 6; Methodology; Methodology, Research; Modeling; Modification; Monitor; Multidisciplinary Collaboration; Multidisciplinary Research; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pb element; Persons; Ph.D.; PhD; Phase; Policies; Population; Population Study; Prevalence; Prevention; Prevention Research; Preventive Intervention; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychological adjustment; Public Policy; QOL; Qualitative Methods; Quality of life; Reporting; Research; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Behaviors; Risky Behavior; Role; SCHED; SUBGP; Schedule; Science; Services; Sex Behavior; Sex Functioning; Sexual Activity; Sexual Behavior; Sexuality; Shapes; Specialist; Stigmata; Structure; Study, Interdisciplinary; Subgroup; Surgical; Surgical Interventions; Surgical Procedure; Technology; Testing; Training; Training and Education; Unspecified Mental Disorder; Virus-HIV; Work; Workshop; anti-retroviral; antiretroviral; at risk behavior; base; behavior change; behavioral/social science; ethnographic; heavy metal Pb; heavy metal lead; high risk; improved; innovate; innovation; innovative; instrument; intervention design; interventional strategy; meetings; member; mental illness; multidisciplinary; preventional intervention strategy; programs; psychological disorder; scale up; sex; sex activity; sex risk; sexual functioning; social; social role; social stigma; stigma; surgery; theories; therapy design; treatment design; trend",Interdisciplinary Research Methods Core,,43520,ZMH1,Special Emphasis Panel,,22,,284141
8015616,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9007,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"LEVIN, BRUCE ;",6364999;,5P30MH043520,,,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Analysis, Data; Articulation; Arts; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Sciences; Behavioral Therapy; Behavioral Treatment; Chair; Chairman; Chairperson; Chairwoman; Characteristics; Clinical; Clinical Trials Data Monitoring Committees; Communities; Conditioning Therapy; Data; Data Analyses; Data Base Management; Data Collection; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Developing Countries; Developing Nations; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Ensure; Epidemic; Epidemiology; Faculty; Fostering; Future; GIS; Gender; Generalized Growth; Geographic Information Systems; Goals; Grant; Growth; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Infectious Disease Epidemiology; Infectious Epidemiology; Infrastructure; Instrumentation, Other; International; Intervention; Intervention Strategies; Intervention Studies; Intervention Trial; Investigators; Joints; LAV-HTLV-III; Leadership; Less-Developed Countries; Less-Developed Nations; Life Style Modification; Lymphadenopathy-Associated Virus; M.D.; Marshal; Mental Health; Mental Hygiene; Methods; Mission; Models, Statistical; Monitor; Observational Study; On-Line Systems; Online Systems; Performance; Ph.D.; PhD; Position; Positioning Attribute; Preparation; Prevention; Probabilistic Models; Production; Productivity; Psychiatry; Psychological Health; Public Health Schools; Publications; Quality, Data; Randomized; Randomized Controlled Trials; Recommendation; Research; Research Design; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resolution; Resources; Risk; Role; Safety Monitoring Boards; Schools, Public Health; Science; Science of Statistics; Scientific Publication; Senior Scientist; Sexuality; Social Behavior; Solutions; Specialist; Staging; Statistical Models; Statistics; Strategic Planning; Structure; Study Type; T-Lymphotropic Virus Type III Infections, Human; Technology; Third-World Countries; Third-World Nations; Tissue Growth; Transmission; Under-Developed Countries; Under-Developed Nations; Virus-HIV; behavior intervention; behavioral intervention; career; comparative; data management; design; designing; distributed data; epidemiologic data; experience; geographic information system; high standard; improved; innovate; innovation; innovative; instrumentation; interventional strategy; meetings; member; multi-site trial; online computer; ontogeny; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; relational database; response; skills; social; social organization; social role; sociobehavior; sociobehavioral; statistics; study design; transmission process; web based","Statistics, Epidemiology, and Data Management Core",,43520,ZMH1,Special Emphasis Panel,,22,,373364
8015617,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9008,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"CARBALLO-DIEGUEZ, ALEX ;",1964642;,5P30MH043520,,,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Approaches to prevention; Arts; Attention; Award; Awareness; Awarenesses; Behavior; Cessation of life; Clinical; Communication; Consultations; Data; Data Collection; Death; Development; Doctor of Philosophy; Economics; Educational workshop; Emergent Technologies; Emerging Technologies; Environment; Epidemic; Epidemiology; Faculty; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Home; Home environment; Hour; Human Immunodeficiency Viruses; Human Resources; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Information Technology; International; Internet; Intervention; Intervention Strategies; Investigation; Investigators; LAV-HTLV-III; Learning; Lymphadenopathy-Associated Virus; Manpower; Manuscripts; Output; Participant; Ph.D.; PhD; Pilot Projects; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Prevention Research; Prevention approach; Process; Programs (PT); Programs [Publication Type]; Publications; Race; Racial Group; Research; Research Associate; Research Personnel; Research Resources; Researchers; Resources; Role; SCHED; Schedule; Science of Statistics; Scientific Publication; Severities; Statistics; Stocks, Racial; T-Lymphotropic Virus Type III Infections, Human; Training; Virus-HIV; WWW; Work; Workshop; Writing; behavioral/social science; career development; design; designing; improved; innovate; innovation; innovative; interventional strategy; meetings; new technology; next generation; outreach; personnel; pilot study; post-doc; post-doctoral; programs; response; sensitivity training; social; social role; social science research; statistics; web; world wide web",Development Core,,43520,ZMH1,Special Emphasis Panel,,22,,280418
8015618,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9012,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"KLITZMAN, ROBERT L;",1873864;,5P30MH043520,,,"AIDS Virus; AIDS prevention; AIDS test; AIDS/HIV prevention; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Anti-Retroviral Agents; Antiretroviral Agents; Area; Behavior; Care, Health; Clinical; Communities; Condoms, Female; Consult; Consultations; Doctor of Medicine; Doctor of Philosophy; Economic Policy; Education; Educational aspects; Empirical Research; Epidemic; Ethics; Ethics Committees, Research; Ethics, Research; Female Condoms; Fostering; Goals; Grant; HIV; HIV Prevention; HIV test; HIV/AIDS prevention; HTLV-III; Healthcare; Hour; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; IRBs; Infection; Information Technology; Institution; Institutional Review Boards; International; Investigators; LAV-HTLV-III; Life; Lymphadenopathy-Associated Virus; M.D.; Manuscripts; Ph.D.; PhD; Policies; Policy Research; Policy, Economic; Population; Prevention; Programs (PT); Programs [Publication Type]; Research; Research Ethics; Research Ethics Committees; Research Personnel; Research Support; Researchers; Rest; Risk; SCHED; Schedule; Scholarship; Technology; Virus-HIV; Work; Writing; anti-retroviral; antiretroviral; conference; experiment; experimental research; experimental study; high risk; meetings; member; microbicidal; microbicide; policy implication; programs; research study; scale up; symposium; technology development",Ethics and Policy Core,,43520,ZMH1,Special Emphasis Panel,,22,,227966
8015619,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9013,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"EHRHARDT, ANKE A;",1876860;,5P30MH043520,,,"AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Advocate; Affect; Area; Arts; Behavior; Clinical; Clinical Trials Data Monitoring Committees; Collaborations; Communities; Country; Data Monitoring Committees; Data and Safety Monitoring Boards; Decision Making; Doctor of Medicine; Doctor of Philosophy; Ensure; Environment; Epidemic; Ethics; Foundations; Government; HIV; HIV Prevention; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HOSP; HTLV-III; Hospitals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Institutes; Institution; Interdisciplinary Research; Interdisciplinary Study; International; Interruption; Investigators; LAV-HTLV-III; Leadership; Lymphadenopathy-Associated Virus; M.B.A.; M.D.; M.P.H.; Master of Business Administration; Master of Public Health; Mental Health; Mental Hygiene; Methodology, Research; Mission; Monitor; Multidisciplinary Collaboration; Multidisciplinary Research; New York; Operation; Operative Procedures; Operative Surgical Procedures; Organization Charts; P-30; P-30 Protein; P30; P30 Protein; PROV; Participant; Peer Review; Performance; Ph.D.; PhD; Policies; Policy Maker; Population; Presbyterian Church; Presbyterians; Pressure; Pressure- physical agent; Principal Investigator; Program Evaluation; Provider; Psychological Health; Public Health; Quality Control; R01 Mechanism; R01 Program; RPG; Recommendation; Research; Research Grants; Research Methodology; Research Methods; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; SCHED; Safety Monitoring Boards; Schedule; Scientist; Services; Shapes; Strategic Planning; Structure; Students; Study, Interdisciplinary; Surgical; Surgical Interventions; Surgical Procedure; Universities; Virus-HIV; Visit; Work; community based service; community consultation; cost; innovate; innovation; innovative; meetings; member; metropolitan; multidisciplinary; organizational structure; pressure; public health medicine (field); ranpirnase; response; surgery",Administrative Core,,43520,ZMH1,Special Emphasis Panel,,22,,534593
8015620,P30,MH,5,,02/01/2010,01/31/2011,,5P30MH043520-22,9014,,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MENANDS,UNITED STATES,,21,,US,NY,12204,NEW YORK STATE PSYCHIATRIC INSTITUTE,"REMIEN, ROBERT H;",1891235;,5P30MH043520,,,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Academia; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Affect; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Research; Behavioral Therapy; Behavioral Treatment; Brazil; Caring; Case Study; China; Clinical; Collaborations; Commit; Communities; Community Healthcare; Community Services; Conditioning Therapy; Country; Development; Doctor of Philosophy; Dominican Republic; Ensure; Epidemic; Faculty; Family; Fostering; Funding Mechanisms; Geography; Government; Government Agencies; HIV; HIV/AIDS; HIV/AIDS problem; HTLV-III; Health; Health Care, Community; Healthcares, Community; Home; Home environment; Hour; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; India; Individual; Institution; Interdisciplinary Research; Interdisciplinary Study; International; Intervention; Intervention Strategies; Investigators; Journals; Knowledge; LAV-HTLV-III; Leadership; Life; Life Style Modification; Location; Low income; Lymphadenopathy-Associated Virus; Magazine; Mainland China; Maintenance; Maintenances; Mexico; Modeling; Multidisciplinary Collaboration; Multidisciplinary Research; Multinational Perspectives; New York City; On-Line Systems; Online Systems; Perspectives, International; Ph.D.; PhD; Policy Research; Prevention; Prevention program; Process; Programs (PT); Programs [Publication Type]; Public Health Schools; Public Policy; Publications; Republic of South Africa; Research; Research Personnel; Research Priority; Research Resources; Researchers; Resource Development; Resources; SCHED; Schedule; Schools, Public Health; Science; Scientific Publication; Scientist; South Africa; Study, Interdisciplinary; Translating; Translatings; Union of South Africa; Universities; Viet Nam; Vietnam; Vietnam, Republic of; Virus-HIV; antiretroviral therapy; base; behavior intervention; behavioral intervention; case report; community based participatory research; community organizations; experience; health practice; high risk; interest; international center; interventional strategy; language translation; meetings; member; online computer; programs; response; scale up; social organization; success; tool; treatment program; web based",Global Community Core,,43520,ZMH1,Special Emphasis Panel,,22,,314786
7754450,P50,AA,5,,01/01/2010,12/31/2010,AA-05-001,5P50AA010761-15,,NIAAA:1695716;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,PSYCHIATRY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"RANDALL, CARRIE L;",1895804;,5P50AA010761,12/10/1995,12/31/2010,,Alcohol Research Center - Treatment and Implications,,10761,ZAA1,Special Emphasis Panel,,15,1695716,
8014971,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,0010,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"ANTON, RAYMOND F;",1873408;,5P50AA010761,,,"1,2-benzenediol; 1,2-dihydroxybenzene; 1H-Purin-6-amine; 2-Amino-6-Hydroxypurine; 2-hydroxyphenol; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 6H-Purin-6-one, 2-amino-1,7-dihydro-; Abstinence; Accounting; Acute; Address; Adenine; Affect; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholic; Alcoholism; Alcohols; Alleles; Allelomorphs; Amino Acid Substitution; Amino Acids; Area; Asparagine; Aspartate; Binding; Binding (Molecular Function); Biological; Boozer; Brain; Brain imaging; Brain scan; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; C-Fragment Endorphin; COMT; Catechol Methyltransferase; Catechol O-Methyltransferase; Catechols; Chemical Class, Alcohol; Clinical; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Cues; Data; Dependent drinker; Development; Dopamine; Dose; Drug Therapy; Drugs; Du Pont Brand of Naltrexone Hydrochloride; EC 2; EC 2.1.1.6; Encephalon; Encephalons; Enzymes; EtOH drinking; Ethanol dependence; External Domain; Extracellular Domain; Functional Magnetic Resonance Imaging; Future; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Structures; Genetic Variation; Genetics, Other; Genotype; Goals; Guanine; Hour; Human; Human, General; Hydroxytyramine; Imaging technology; Individual; Intoxication; L-Asparagine; L-Aspartate; Laboratories; Lamepro Brand of Naltrexone Hydrochloride; Lipotropin 61-91; Lipotropin Fragment C; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measures; Medical; Medication; Medicine; Molecular Interaction; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; N-terminal; NH2-terminal; Nalorex; Naltrexone; Narcotic Antagonists; Nemexin; Nervous System, Brain; Neurochemistry; Nucleic Acids; Nucleotides; Nucleus Accumbens; Opiate Antagonist; Opioid Antagonists; Opioid Receptor; Orphan Brand of Naltrexone Hydrochloride; Other Genetics; Output; PBO; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenetics; Pharmacogenomics; Pharmacotherapy; Placebos; Population; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Proteins; Pyrocatechols; Randomized; ReVia; Receptor Gene; Receptor Protein; Receptors, Opiate; Receptors, Opioid, mu; Receptors, mu; Relapse; Research; Role; S-Adenosyl-L-methionine[{..}]catechol O-methyltransferase; Schering-Plough Brand of Naltrexone Hydrochloride; Science of Medicine; Science of neurochemistry; Sedation procedure; Sham Treatment; Site; System; System, LOINC Axis 4; Testing; Time; Transferase; Transferase Gene; Treatment Efficacy; United Drug Brand of Naltrexone Hydrochloride; Variant; Variation; Variation (Genetics); Vitamin B4; Work; alcohol abuse therapy; alcohol abuse treatment; alcohol addiction; alcohol addiction therapy; alcohol cue; alcohol dependence therapy; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol treatment; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism pharmacotherapy; alcoholism therapy; alcoholism treatment; allelic variant; aminoacid; beta-Endorphin; beta-LPH (61-91); beta-Lipotropin C Fragment; brain visualization; clinical investigation; craving; drinking; drinking behavior; drug/agent; ethanol addiction; ethanol consumption; ethanol cue; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol use; ethanol-dependent; etoh use; experience; fMRI; gene interaction; gene product; genetic profiling; genetic variant; meetings; neurochemistry; neuroimaging; o-Dihydroxybenzenes; ortho-Dihydroxybenzenes; problem drinker; programs; randomisation; randomization; randomly assigned; receptor; response; sedation; sham therapy; social role; therapeutic efficacy; therapeutically effective; treatment center; treatment response",Evaluating the Genetic Variability of Naltrexone Response,,10761,ZAA1,Special Emphasis Panel,,15,,272962
8014972,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,0011,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BECKER, HOWARD C.;",1959504;,5P50AA010761,,,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Absolute ethanol; Abstinence; Acute; Addiction, Drug; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcohol, Ethyl; Alcoholism; Alcohols; Animal Model; Animal Models and Related Studies; Animals; Behavioral; Brain; Characteristics; Chemical Class, Alcohol; Chemical Dependence; Chronic; Consumption; Dependence; Dependence, Drug; Development; Dopamine; Drug Addiction; Drug Delivery; Drug Delivery Systems; Drug Dependency; Drug Targeting; Drug Targetings; Drug Therapy; Drugs; ETOH; Encephalon; Encephalons; EtOH drinking; Ethanol; Ethanol dependence; Evaluation; Glutamates; Goals; Grain Alcohol; Heavy Drinking; Hydroxytyramine; Intake; Investigators; L-Glutamate; Literature; Mammals, Mice; Measures; Mediating; Medical; Medication; Methylcarbinol; Mice; Microdialysis; Modeling; Motivation; Murine; Mus; Nerve Transmitter Substances; Nervous; Nervous System, Brain; Neurochemistry; Neurosciences Research; Neurotransmitters; Nucleus Accumbens; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Play; Pre-Clinical Model; Preclinical Models; Procedures; Property; Property, LOINC Axis 2; Recurrent disease; Relapse; Relapsed Disease; Research; Research Personnel; Researchers; Rewards; Role; Science of neurochemistry; Self Administration; Shapes; Social Problems; Staging; Structure; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Agents; Therapeutic Intervention; Transmission; Withdrawal; addiction; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; dependence relapse; drink heavily; drinking; drinking behavior; drug/agent; effective therapy; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol use; ethanol-dependent; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experience; extracellular; extreme drinking; heavy alcohol use; in vivo; innovate; innovation; innovative; intervention therapy; model organism; mouse model; neural; neurochemistry; pathway; prevent; preventing; relating to nervous system; social disturbance; social role; transmission process; treatment center; treatment strategy",Pharmacotherapy for Alcohol Dependence and Relapse,,10761,ZAA1,Special Emphasis Panel,,15,,332313
8014973,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,0012,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"MYRICK, DONALD L;",2281573;,5P50AA010761,,,"1-(aminomethyl)cyclohexaneacetic Acid; Abstinence; Acoustic; Acoustics; Acute; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholic; Alcohols; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Anxiety; Behavior; Behavioral; Boozer; Brain; Chemical Class, Alcohol; Client; Clinical Research; Clinical Study; Clinical Treatment; Controlled Clinical Trials; Data; Dependent drinker; Distress; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Metabolic Detoxication; Drug Therapy; Drugs; Encephalon; Encephalons; Enrollment; EtOH drinking; Ethanol dependence; Frequencies (time pattern); Frequency; Funding; Future; Glutamates; Housing; Impairment; Investigation; L-Glutamate; Measures; Medical center; Medication; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Moods; Motor; Nerve Transmitter Substances; Nervous System, Brain; Neurologic; Neurological; Neurontin; Neurotransmitters; Out-patients; Outcome; Outpatients; PBO; Patient Self-Report; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Placebo Control; Placebos; Play; Prevention of relapse; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Reflex; Reflex action; Relapse; Reporting; Research; Residential Treatment; Rest; Role; Self-Report; Sham Treatment; Sleep; Substance abuse problem; Symptoms; System; System, LOINC Axis 4; Technology; Testing; Time; Transcranial magnetic stimulation; Treatment outcome; United States Department of Veterans Affairs; United States Veterans Administration; Veterans Administration; Veterans Administration (U.S.); Veterans Affairs (U.S.); Withdrawal Symptom; abuse of substances; alcohol abuse therapy; alcohol abuse treatment; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol treatment; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism treatment; craving; design; designing; detoxification; disorder later incidence prevention; drinking; drug/agent; enroll; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol use; ethanol-dependent; etoh use; experience; gabapentin; improved; indexing; interest; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; problem drinker; programs; psychosocial; satisfaction; sham therapy; social role; substance abuse; treatment center; treatment program; trial regimen; trial treatment",Pharmacological Treatment of Early Abstinence Symptoms,,10761,ZAA1,Special Emphasis Panel,,15,,209509
8014974,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,0013,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"WOODWARD, JOHN J;",1888363;,5P50AA010761,,,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Absolute ethanol; Abstinence; Action Potentials; Acute; Addictive Behavior; Affect; Alcohol withdrawal syndrome; Alcohol, Ethyl; Alcoholic; Alcoholism; Ammon Horn; Anesthesia; Anesthesia procedures; Anesthetics, General; Animals; Behavior; Boozer; Brain; Brain imaging; Cells; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Compulsive Behavior; Cornu Ammonis; Cues; DA Neuron; Data; Dependent drinker; Development; Dopamine; Dopamine neuron; Drug Therapy; ETOH; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Ethanol; Ethanol dependence; Event; Exposure to; General anesthetic drugs; Generations; Goals; Grain Alcohol; Hippocampus; Hippocampus (Brain); Hydroxytyramine; Imaging Procedures; Imaging Techniques; In Vitro; Investigators; Lead; Measures; Mediating; Methods; Methylcarbinol; Monitor; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Obsessive compulsive behavior; Pattern; Pb element; Pharmacotherapy; Prefrontal Cortex; Pyramidal Cells; Pyramidal neuron; Research Personnel; Researchers; Role; Sensory Process; Site; Slice; Synapses; Synaptic; System; System, LOINC Axis 4; Technics, Imaging; Testing; Time; Visual; Withdrawal; addiction; alcohol effect; alcohol exposed; alcohol exposure; alcohol research; alcohol withdrawal; brain visualization; dependence relapse; dopaminergic neuron; drinking; drinking behavior; ethanol addiction; ethanol effect; ethanol exposed; ethanol exposure; ethanol research; ethanol withdrawal; exposed to alcohol; exposure to alcohol; heavy metal Pb; heavy metal lead; hippocampal; hippocampal pyramidal neuron; in vivo; neuronal; novel; patch clamp; problem drinker; social role; treatment center; voltage clamp; withdrawal from alcohol",Ethanol and Persistent Activity in Prefrontal Cortex,,10761,ZAA1,Special Emphasis Panel,,15,,227124
8014975,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,0014,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"THOMAS, SUZANNE E;",2047696;,5P50AA010761,,,"Abstinence; Acute; Address; Advertisements; Affect; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholic; Alcoholic Beverages; Alcoholism; Alcohols; Anxiety; Attenuated; Automobile Driving; Basic Research; Basic Science; Behavior; Behavioral Model; Boozer; Characteristics; Chemical Class, Alcohol; Clinic; Clinical; Clinical Research; Clinical Study; Cognitive; Consumption; Cues; Data; Dependent drinker; Dose; Drivings, Automobile; Drug Therapy; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Exposure to; Family Medical History; Family history of; Female; Future; Gender; Gender Role; Goals; Individual; Investigators; Laboratories; Laboratory Study; Measurable; Measures; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Modeling; Moods; Motivation; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Patient Self-Report; Pharmacotherapy; Physiologic; Physiological; Pre-Clinical Model; Preclinical Models; Procedures; Relapse; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Risk; Risk Factors; Self-Report; Sensory; Severities; Sex Roles; Stress; System; System, LOINC Axis 4; Techniques; Testing; Trier Social Stress Test; United States National Institutes of Health; Woman; alcohol addiction; alcohol addiction therapy; alcohol craving; alcohol cue; alcohol dependence therapy; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol relapse; alcohol research; alcohol response; alcohol seeking; alcohol seeking behavior; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism therapy; base; biological adaptation to stress; cue reactivity; drinking; driving; ethanol addiction; ethanol consumption; ethanol craving; ethanol cue; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol relapse; ethanol research; ethanol response; ethanol seeking; ethanol use; ethanol-dependent; ethanol-seeking behavior; etoh use; experiment; experimental research; experimental study; improved; indexing; male; men; men's; negative mood; person centered; preclinical study; prevent; preventing; problem drinker; psychological stressor; reaction; crisis; research study; response; response to alcohol; response to ethanol; social; stress response; stress; reaction; stressor; treatment center",Effect of Stress on Precipitants to Alcohol Relapse,,10761,ZAA1,Special Emphasis Panel,,15,,188253
8014976,P50,AA,5,,01/01/2010,12/31/2010,,5P50AA010761-15,9001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"THOMAS, SUZANNE E;",2047696;,5P50AA010761,,,"Advertising; Alcohols; Area; Basic Research; Basic Science; Chemical Class, Alcohol; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Consult; Contracting Opportunities; Contracts; Cost Savings; Data Base Management; Ensure; Environment; Funding; Goals; Housing; Individual; Intake; Investigators; Medical; Medical Specialities; Pharmaceutical Services; Pilot Projects; Price; Quality Control; Research; Research Personnel; Researchers; Saving, Cost; Science of Statistics; Screening procedure; Services; Services, Pharmaceutic; Services, Pharmacy; Specialties, Medical; Specialty; Statistics; System; System, LOINC Axis 4; Time; Training; alcohol research; authority; clinical investigation; ethanol research; experiment; experimental research; experimental study; medical specialties; meetings; pilot study; prevent; preventing; pricing; research study; screening; screenings; service utilization; statistics; treatment center",Shared Core,,10761,ZAA1,Special Emphasis Panel,,15,,465555
7798243,P50,AA,5,,01/01/2010,12/31/2010,AA-08-005,5P50AA011999-12,,NIAAA:1603800;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LOS ANGELES,UNITED STATES,PATHOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"TSUKAMOTO, HIDEKAZU ;",2109313;,5P50AA011999,01/01/1999,12/31/2013,,Southern California Research Center for ALPD and Cirrhosis,,11999,ZAA1,Special Emphasis Panel,,12,1603800,
7754072,P50,HL,5,,01/01/2010,12/31/2010,HL-05-007,5P50HL084923-04,,NHLBI:2201857;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,PEDIATRICS,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"STENMARK, KURT R;",1866846;,5P50HL084923,01/12/2007,12/31/2011,,Lung Vascular Disease in Infants and Children: Mechanisms and Treatment,,84923,ZHL1,Special Emphasis Panel,,4,2201857,
8016052,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,0001,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"KINSELLA, JOHN PATRICK;",1965857;,5P50HL084923,,,"0-11 years old; 0-6 weeks old; Active Follow-up; Acute Pulmonary Injury; Address; Adverse effects; Affect; Animal Experiments; Aspiration, Respiratory; Attention; BPD; Birth Weight; Blood Vessels; Breathing; Bronchopulmonary Dysplasia; CPAP; CPAP Ventilation; Categories; Cell Communication and Signaling; Cell Signaling; Chi-Square Tests; Child; Child Youth; Children (0-21); Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Colorado; Confidence Intervals; Conflict; Conflict (Psychology); Consent; Continuous Positive Airway Pressure; Data; Development; Disease; Disorder; Dose; Dysfunction; Early treatment; Effects, Longterm; Employee Strikes; Enrollment; Environmental air flow; Evaluation; Event; Exclusion Criteria; Experiments, Animal; Fetal Age; Fetal Maturity, Chronologic; Functional disorder; Funding; Generalized Growth; Gestation; Gestational Age; Grant; Growth; Guidelines; Hour; Human, Child; Hypertension, Pulmonary; Hypoxemia; Incidence; Infant; Infant, Newborn; Infant, Premature; Inhalation; Inhaling; Injury; Inspiration, Respiratory; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Intracranial Hemorrhages; Intubation; Investigators; Life; Light; Living Wills; Long-Term Effects; Lung; Lung Inflammation; Lung Injury, Acute; Masks; Mechanical ventilation; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multicenter Trials; NIH; Nasal; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institutes of Health (U.S.); Neonatal Screening; Newborn Infant; Newborn Infant Screening; Newborns; Nose; Nose, Nasal Passages; O element; O2 element; Oxygen; PBO; Patients; Photoradiation; Physiopathology; Pilot Projects; Placebo Control; Placebos; Population; Pregnancy; Premature Infant; Pressure; Pressure- physical agent; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Pulmonary Circulation; Pulmonary Hypertension; Randomized; Randomized Controlled Trials; Reporting; Research Personnel; Researchers; Respiratory Circulation; Respiratory Failure; Respiratory System, Lung; Respiratory System, Nose, Nasal Passages; Risk; Role; Safety; Sample Size; Sampling; Series; Severities; Severity of illness; Sham Treatment; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Steroid Compound; Steroids; Strikes; Strikes, Employee; Structure; Testing; Tests, Chi-Square; Tissue Growth; Treatment Side Effects; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Disorder; Ventilation; Ventilator-induced lung injury; Work; acute lung injury; base; bench bed side; bench bedside; bench to bed side; bench to bedside; biological signal transduction; biomarker; blood vessel disorder; children; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; clinical investigation; clinical practice; design; designing; disease severity; disease/disorder; effective therapy; endotracheal; enroll; expectation; experience; follow-up; hypoxemic; iNO; indexing; infant chronic lung disease; inhaled nitric oxide; inspiration; interest; interventional strategy; mechanical respiratory assist; meetings; neonatal chronic lung disease; neonatal pulmonary hypertension; neonate; newborn chronic lung disease; newborn human (0-6 weeks); newborn pulmonary hypertension; newborn screening; novel; ontogeny; oxygen poisoning; oxygen toxicity; pathophysiology; patient population; persistent pulmonary hypertension; pilot study; pilot trial; premature; premature baby; premature infant human; premature lungs; prenatal; pressure; preterm baby; preterm infant; preterm infant human; preterm neonate; programs; pulmonary; pulmonary hypertension in neonate; pulmonary hypertension in newborn; pulmonary hypertension of neonate; pulmonary hypertension of newborn; randomisation; randomization; randomized controlled study; randomly assigned; respiratory; respiratory insufficiency/failure; safety study; sham therapy; side effect; social role; surfactant; therapy adverse effect; treatment adverse effect; trend; unborn; vascular; youngster",Non-Invasive Inhaled NO in Premature Newborns,,84923,ZHL1,Special Emphasis Panel,,4,,455783
8016053,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,0002,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"SHANDAS, ROBIN ;",1880475;,5P50HL084923,,,"0-11 years old; Affect; Blood Vessels; Cardiac Output; Cathetergram; Catheterization; Characteristics; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical; Complex; Computer Simulation; Computerized Models; Development; Diagnostic; Diagnostic Imaging; Disease; Disorder; Doppler Echocardiography; Doppler Study; Echocardiography, Doppler; Electrical Impedance; Evaluation; Human, Child; Hypertension, Pulmonary; Image; Impedance; Infant; Laboratories; Liquid substance; Lung; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Mechanics; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Monitor; Nomograms; Outcome; Patients; Pressure; Pressure- physical agent; Pulmonary Artery; Pulmonary Hypertension; Pulmonary Vascular Resistance; Pulmonary artery structure; Resistance; Respiratory System, Lung; Side; Simulation, Computer based; Structure; Techniques; Vascular Diseases; Vascular Disorder; Vascular Resistance, Pulmonary; Ventricular; arterial stiffness; blood vessel disorder; cardiovascular imaging; children; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; disease/disorder; electric impedance; fluid; heart output; hemodynamics; imaging; in silico; liquid; normotensive; novel; pediatric; pressure; pulmonary; pulmonary arterial hypertension; resistant; shear stress; vascular; virtual simulation; youngster",Advanced Imaging and Diagnostics for Pediatric Pulmonary Hypertension,,84923,ZHL1,Special Emphasis Panel,,4,,418833
8016054,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,0003,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"STENMARK, KURT R;",1866846;,5P50HL084923,,,"0-11 years old; Affect; Ally; Alveolar; Alveolus; Animal Model; Animal Models and Related Studies; Animals; Appearance; Area; Asthma; BPD; Birth; Bleo; Bleomycin; Bleomycin Antibiotic; Blood Vessels; Blood leukocyte; Body Tissues; Bronchial Alveolus; Bronchial Asthma; Bronchopulmonary Dysplasia; Cells; Child; Child Youth; Children (0-21); Chronic; Chronic lung disease; Cold-Insoluble Globulins; Collagen; Common Rat Strains; Complication; Cytokines, Chemotactic; Data; Deposit; Deposition; Development; EDN1; ET-1; ET-1 (Endothelin-1); Endothelin; Endothelin Type 1; Endothelin-1; Endothelium-Derived Vasoconstrictor Factors; Erythrocuprein; FN1; FNZ; Fibroblasts; Fibronectin 1; Fibronectins; Fibrosis; Genetic Models; Goals; HTRPY; Hemocuprein; Homologous Chemotactic Cytokines; Human; Human, Child; Human, General; Hyperoxia; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Hypoxic; Infant; Inflammatory; Inflammatory Response; Intercrines; Investigators; Knock-out; Knockout; LETS Proteins; Large External Transformation-Sensitive Protein; Leiomyocyte; Leukocytes; Lundbeck Brand of Bleomycin Sulfate; Lung; Lung Inflammation; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow leukocyte; Medial; Mediating; Mesenchymal; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Mice; Modeling; Models, Genetic; Morbidity; Morbidity - disease rate; Mother Cells; Murine; Mus; Myocytes, Smooth Muscle; Myofibroblast; Neonatal; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Oxidants; Oxidizing Agents; Oxygen Deficiency; Oxygen Inhalation Therapy; Oxygen Therapy Care; Parturition; Play; Population; Process; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Pulmonary Artery; Pulmonary Hypertension; Pulmonary artery structure; RNA, Small Interfering; Rat; Rattus; Receptor Protein; Recruitment Activity; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Respiratory distress; Reticuloendothelial System, Leukocytes; Risk; Rodent; Rodentia; Rodentias; Role; SIS cytokines; SOD; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Source; Stem cells; Stress; Superoxide Dismutase; Superoxide[{..}]superoxide oxidoreductase; Testing; Therapeutic; Time; Tissues; Vascular Diseases; Vascular Disorder; Vascular remodeling; Ventilator; Warburg Therapy; White Blood Cells; White Cell; Work; Wound Healing; Wound Repair; alpha 2-Surface Binding Glycoprotein; attenuation; blood vessel disorder; chemoattractant cytokine; chemokine; chemokine receptor; children; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; clinical significance; clinically significant; cytocuprein; cytokine; electron acceptor; experiment; experimental research; experimental study; extracellular; improved; in vivo; infant chronic lung disease; lung development; lung injury; model organism; neonatal chronic lung disease; neonatal pulmonary hypertension; newborn chronic lung disease; newborn pulmonary hypertension; novel; oxidant stress; oxygen administration; oxygen stress (breathing); oxygen therapy; prevent; preventing; progenitor; programs; pulmonary; pulmonary hypertension in neonate; pulmonary hypertension in newborn; pulmonary hypertension of neonate; pulmonary hypertension of newborn; receptor; recruit; research study; resistant; response; siRNA; social role; tissue repair; tool; vascular; white blood cell; white blood corpuscle; youngster",Circulating Fibrocytes in Hyperoxic Lung Vascular Remodeling,,84923,ZHL1,Special Emphasis Panel,,4,,355374
8016055,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,0004,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WHITE, CARL W;",1880436;,5P50HL084923,,,"0-11 years old; 0-6 weeks old; 21+ years old; ABC3; ABCA3; ABCA3 gene; ARDS; ARDS, Human; ARDSs, Human; Acute; Adult; Adult RDS; Adult Respiratory Distress Syndrome; Affect; Air; Albumins; Alveolar; Amniotic Fluid; Anemia; Angiogenic Factor; Animals; Aqua Amnii; Area; Aspiration, Respiratory; Autopsy; Autoregulation; BPD; Biosynthetic Proteins; Birth; Birth of Full-Term Infant; Birth of Full-Term Newborn; Blood Circulation; Blood Vessels; Blood capillaries; Blood flow; Blood gas; Bloodstream; Body Tissues; Breathing; Bronchioalveolar Lavage; Bronchoalveolar Lavage; Bronchopulmonary Dysplasia; CNOS; Capillaries; Capillary; Capillary, Unspecified; Cardiorespiratory distress syndrome of newborn; Carrier Proteins; Cell Communication and Signaling; Cell Signaling; Cells; Cessation of life; Child; Child Youth; Children (0-21); Choline Glycerophospholipids; Choline Phosphoglycerides; Chronic; Circulation; Congenital alveolar dysplasia; Constitutive NOS; Data; Death; Development; Disease; Disorder; Dose; Dropsy; Drugs; Ductal; Ductus Arteriosus; Ductus Arteriosus, Patent; ECNOS; ECSF; ENOS; Economic Inflation; Edema; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Environment; Epithelial; Epithelial Cells; Epithelium; Epoetin; Equilibrium; Erythropoietin; Face; Factor, Angiogenesis; Fetal Lung; Fetus; Frequencies (time pattern); Frequency; Fullterm Birth; Gene Expression; Gene Family; Genes; Gestation; Growth and Development; Growth and Development function; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Homeostasis; Human, Adult; Human, Child; Hydrops; Hyperoxia; Hypertension, Pulmonary; Hypoxia; Hypoxia Inducible Factor; Hypoxic; INFLM; IRDS of newborn; Idiopathic respiratory distress syndrome; Idiopathic respiratory distress syndrome of newborn; Infant; Infant, Newborn; Infant, Premature; Inflammation; Inflammatory; Inflation; Inhalation; Inhaling; Injury; Inspiration, Respiratory; Instrumentation, Other; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knowledge; Last Trimester; Lavage, Bronchopulmonary; Lecithin; Left pulmonary artery; Lipid Trafficking; Lipids; Liquor Amnii; Lung; Lung Compliance; Lung Lavage; Lung Parenchyma; Lung Tissue; Mammals, Primates; Measurement; Measures; Mechanics; Medication; Messenger RNA; Mice, Transgenic; Modeling; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Neonatal; Neonatal Respiratory Distress Syndrome; Newborn Infant; Newborn RDS; Newborn Respiratory Distress Syndrome; Newborns; Nitric Oxide Synthase 3; O element; O2 element; Operation; Operative Procedures; Operative Surgical Procedures; Oxygen; Oxygen Deficiency; Oxygen measurement, partial pressure, arterial; Parturition; Patent Ductus Arteriosus; Peptidyl Prolyl Hydroxylase; Perinatal; Perinatal Pulmonary Hypertension; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphatidylcholines; Physiological Homeostasis; Pregnancy; Pregnancy Trimester, Third; Premature Birth; Premature Infant; Pressure; Pressure- physical agent; Preterm Birth; Primates; Process; Procollagen Prolyl 4-Hydroxylase; Procollagen-L-proline,2-oxoglutarate[{..}]oxygen oxidoreductase; Procollagen-Proline Dioxygenase; Production; Programs (PT); Programs [Publication Type]; Proline Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Prolyl 4-Hydroxylase; Prolyl Hydroxylase; Proteins; Protocollagen Prolyl Hydroxylase; Pulmonary Artery; Pulmonary Circulation; Pulmonary Gas Exchange; Pulmonary Hypertension; Pulmonary artery structure; Pulmonary hypoperfusion syndrome of newborn; RDS, type I; RNA, Messenger; Receptor Protein; Recombinant Proteins; Relative; Relative (related person); Relaxation; Reporting; Research Personnel; Researchers; Respiratory Circulation; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome, Perinatal; Respiratory System, Lung; Respiratory distress; Respiratory physiology; Role; Route; Shock Lung; Signal Transduction; Signal Transduction Systems; Signaling; Structure of ductus arteriosus; Structure of parenchyma of lung; Surface; Surfactant deficiency syndrome neonatal; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Term Birth; Therapeutic; Therapeutic Uses; Third Pregnancy Trimester; Tissues; Transgenic Mice; Transport Proteins; Transporter Protein; Trimester, Third; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular remodeling; Vasodilatation; Vasodilation; Vasorelaxation; Vegf; Waters (Amniotic Fluid); Wet lung disease of newborn; adult human (21+); angiogenesis; arterial pO2; ascorbate; balance; balance function; base; biological signal transduction; blood vessel disorder; bronchopulmonary lavage therapy; capillary; children; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; cofactor; cost; cytokine; disease/disorder; distress; respiratory, newborn; drug/agent; eNOS enzyme; endothelial constitutive nitric oxide synthase; erythrocyte colony stimulating factor; facial; fetal; gene product; hematopoietin; hemodynamics; human NOS3 protein; hypoxia inducible factor 1; idiopathic respiratory distress of newborn; improved; in utero; in vitro Model; in vivo; indexing; infant chronic lung disease; inhibitor; inhibitor/antagonist; inspiration; instrument; instrumentation; lipid transport; lung development; lung function; lung hypoxia; mRNA; morphometry; necropsy; neonatal RDS; neonatal chronic lung disease; neonatal pulmonary hypertension; neonate; newborn chronic lung disease; newborn human (0-6 weeks); newborn pulmonary hypertension; oxygen stress (breathing); oxygen tension; persistent pulmonary hypertension; postmortem; postnatal; premature baby; premature childbirth; premature delivery; premature infant human; prenatal; pressure; preterm baby; preterm delivery; preterm infant; preterm infant human; preterm neonate; programs; protein expression; pulmonary; pulmonary hypertension in neonate; pulmonary hypertension in newborn; pulmonary hypertension of neonate; pulmonary hypertension of newborn; pulmonary hypoxia; receptor; respiratory distress syndrome; respiratory function; social role; surfactant; surgery; trend; unborn; vascular; vascular bed; youngster",Hypoxic-Inducible Factors in Neonatal Pulmonary Hypertension,,84923,ZHL1,Special Emphasis Panel,,4,,591764
8016056,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,9001,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"CHANG, LING-YI L;",1938683;,5P50HL084923,,,"0-11 years old; Adventitia; Alveolar; Area; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Blood capillaries; Body Tissues; Capillaries; Capillary; Capillary, Unspecified; Child; Child Youth; Children (0-21); Development; Heterophil Granulocyte; Human, Child; Infant; Intercept; Length; Lung; Lung Parenchyma; Lung Tissue; Marrow Neutrophil; Measures; Muscle; Muscle Tissue; Neonatal; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Pulmonary Artery; Pulmonary artery structure; R01 Mechanism; R01 Program; RPG; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Respiratory System, Lung; Sampling; Staining method; Stainings; Stains; Structure of parenchyma of lung; Surface; Thick; Thickness; Tissues; Tunica Adventitia; Vascular Diseases; Vascular Disorder; blood vessel disorder; capillary; children; digital; morphometry; neutrophil; programs; pulmonary; vascular; youngster",CORE--Morphometric,,84923,ZHL1,Special Emphasis Panel,,4,,182550
8016057,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,9002,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"ABMAN, STEVEN HERBERT;",1902094;,5P50HL084923,,,"21+ years old; Address; Adult; Advisory Committees; Animal Model; Animal Models and Related Studies; Area; Atmosphere; Atmosphere, planetary; Basic Research; Basic Science; Bio-Informatics; Bioinformatics; Biomedical Engineering; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Childhood; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Study; Clinical Trials Design; Colorado; Communication; Complex; Development; Disease; Disorder; Doctor of Philosophy; Educational process of instructing; Educational workshop; Environment; Epidemiology; Ethics; Exposure to; Generations; Genetic; Genetics, Human; Genomics; Goals; Government; Grant; Head; Health; Heart; Hospitals, Pediatric; Human Genetics; Human, Adult; Hypertension, Pulmonary; Industry; Institution; Institutional Award; Institutional National Research Service Award; Interdisciplinary Research; Interdisciplinary Study; Investigators; Laboratories; Laboratory Scientists; Lead; Learning; Lung; Medicine; Mentors; Mentorship; Multidisciplinary Collaboration; Multidisciplinary Research; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organ System, Cardiovascular; Outcomes Research; Oxidants; Oxidizing Agents; Participant; Patients; Pb element; Pediatric Hospitals; Pediatrics; Ph.D.; PhD; Physiology; Pneumology; Pneumonology; Population; Process; Programs (PT); Programs [Publication Type]; Proteomics; Pulmonary Disease (Specialty); Pulmonary Hypertension; Pulmonary Medicine; Pulmonology; Research; Research Personnel; Research Resources; Research, Outcomes; Researchers; Resources; Respiratory System, Lung; Safety; Science; Science of Medicine; Scientist; Scientists, Laboratory; Series; Structure; Study, Interdisciplinary; T32 Mechanism; T32 Program; Task Forces; Teaching; Time; Training; Training Programs; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Disorder; Vascular, Heart; Work; Workshop; adult human (21+); bench bed side; bench bedside; bench to bed side; bench to bedside; bioengineering; bioengineering/biomedical engineering; blood vessel disorder; career development; circulatory system; conference; disease/disorder; drug development; electron acceptor; experience; genetic epidemiology; heavy metal Pb; heavy metal lead; language translation; model organism; multidisciplinary; novel; patient oriented research; patient oriented study; pediatric; planetary Atmosphere; pre-clinical; preclinical; programs; pulmonary; skills; success; symposium; translation research enterprise",CORE--Clinical Research Skills Development,,84923,ZHL1,Special Emphasis Panel,,4,,101326
8016058,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084923-04,9003,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"STENMARK, KURT R;",1866846;,5P50HL084923,,,"0-11 years old; Accounting; Administrator; Advertising; Animal Experimental Use; Animal Experimentation; Animal Research; Animals; Blood-Borne Pathogens; Bloodborne Pathogens; Budgets; Categories; Charge; Child; Child Youth; Children (0-21); Colorado; Communication; Computers; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Direct Costs; Ensure; Equipment; Expenditure; F and A; Face; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Faculty; Fees; Goals; Grant; Graph; Hazardous Waste; Health Sciences; Hour; Human Resources; Human, Child; Indirect Costs; Infant; Investigators; Laboratories; Link; Location; Lung; Manpower; Manuscripts; Monitor; Names; Out-patients; Outpatients; Patients; Preparation; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Radiation; Regulation; Reporting; Research; Research Personnel; Researchers; Respiratory System, Lung; Role; Route; Running; Safety; Salaries; Services; Sick Leave; Solutions; Students; System; System, LOINC Axis 4; Training; Travel; Universities; Update; Vascular Diseases; Vascular Disorder; Wages; Work; base; blood vessel disorder; children; clinical data repository; clinical data warehouse; conference; cost; data repository; experience; facial; personnel; prevent; preventing; programs; pulmonary; ray (radiation); relational database; social role; symposium; web site; youngster",Administrative,,84923,ZHL1,Special Emphasis Panel,,4,,96227
7802262,P50,HL,5,,01/01/2010,12/31/2010,HL-05-007,5P50HL084946-04,,NHLBI:4144079;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HASSOUN, PAUL M;",1885391;,5P50HL084946,01/12/2007,12/31/2011,,Molecular Determinants of Pulmonary Arterial Hypertension,,84946,ZHL1,Special Emphasis Panel,,4,4144079,
8013836,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,0001,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HASSOUN, PAUL M;",1885391;,5P50HL084946,,,"Accounting; Address; African American; Afro American; Afroamerican; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Arts; Biological; Black Populations; Black or African American; Blood Vessels; Candidate Disease Gene; Candidate Gene; Cardiopulmonary; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Categories; Cessation of life; Characteristics; Clinical; Clinical Research; Clinical Study; Code; Coding System; Complement; Complement Proteins; DISSEC; DNA; Data; Death; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disorder; Dissection; Dysfunction; Expression Profiling; Expression Signature; FLR; Failure (biologic function); Frequencies (time pattern); Frequency; Functional disorder; Future; Gene Cluster; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Haplotypes; Human; Human Resources; Human, General; Hypertension, Pulmonary; Investigators; Link; Literature; Lung; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Manpower; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mind; Molecular; Molecular Fingerprinting; Molecular Profiling; Mortality; Mortality Vital Statistics; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Nucleic Acid Regulatory Sequences; Organ System, Cardiovascular; Outcome; Outcome Measure; Patients; Pattern; Phenotype; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Prevalence; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Pulmonary Hypertension; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research Design; Research Personnel; Researchers; Respiratory System, Lung; Right Ventricular Function; Right-On; Scleroderma; Sclerosis, Systemic; Severities; Study Type; Susceptibility; Syndrome; Systemic Scleroderma; Technology; Testing; Therapeutic; Transcript Expression Analyses; Transcript Expression Analysis; Validation; Variant; Variation; Vascular, Heart; Ventricular; Ventricular Function, Right; Walking; Work; Zeugmatography; analytical tool; base; biomarker; black American; cDNA Arrays; cDNA Microarray; circulatory system; cohort; dermatosclerosis; disease/disorder; effective therapy; failure; genetic regulatory element; hemodynamics; high risk; improved; instrument; model organism; molecuar profile; molecular signature; novel; pathophysiology; personnel; polymorphism; primary pulmonary hypertension; programs; progressive systemic sclerosis; pulmonary; pulmonary arterial hypertension; response; study design; tool; vascular",SCLERODERMA-ASSOCIATED PAH,,84946,ZHL1,Special Emphasis Panel,,4,,582396
8013837,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,0002,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KASS, DAVID ALAN;",1893055;,5P50HL084946,,,"4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; Active Oxygen; Address; Arteries; Attention; Autopsy; Biopsy; Biopsy Sample; Biopsy Specimen; Blood Vessels; Breathlessness; Cardiac; Cardiac Catheterization Procedures; Cardiac Remodeling, Ventricular; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Catheterization, Cardiac; Causality; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coupling; Data; Death, Sudden; Development; Disease; Disorder; Drugs; Dyspnea; Dyspneas; Electrical Impedance; Endothelin Receptor; Epoprostenol; Etiology; Exercise; Exercise, Physical; FLR; Failure (biologic function); Fatigue; Forecast of outcome; Frequencies (time pattern); Frequency; Goals; HTRPY; Heart Catheterization; Heart Catheterization Pocedure; Heart failure; Hypertension, Pulmonary; Hypertrophy; Impedance; Insertion of catheter into heart chamber; Intervention; Intervention Strategies; Investigators; Isometric Exercise; Isometrics; Lack of Energy; Lung; Measurement; Measures; Mediating; Medication; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Analysis; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells; Muscle Cells, Mature; Muscle-Setting Exercise; Myocardial Remodeling, Ventricular; Myocytes; Organ System, Cardiovascular; Outcome; Output; Oxygen Radicals; PDE; PGI2; PGX; Pathology; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphodiesterases; Play; Pressure; Pressure- physical agent; Pro-Oxidants; Prognosis; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostaglandin I(2); Prostaglandin I2; Pulmonary Artery; Pulmonary Hypertension; Pulmonary artery structure; Randomized Controlled Trials; Reactive Oxygen Species; Receptors, Endothelium-Derived Vasoconstrictor Factor; Relative; Relative (related person); Research Personnel; Researchers; Respiratory System, Lung; Rho-associated kinase; Rho-kinase; Right ventricular structure; Role; Sampling; Scleroderma; Secondary to; Static Exercise; Stress; Sudden Death; Symptoms; Techniques; Testing; Time; Translating; Translatings; Transplantation; Vascular remodeling; Vascular, Heart; Ventricle Remodeling; Ventricles, Right; Ventricular; Ventricular Remodeling; base; bosentan; cardiac failure; circulatory system; clinical investigation; clinical practice; dermatosclerosis; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; electric impedance; failure; hemodynamics; improved; indexing; inhibitor; inhibitor/antagonist; interventional strategy; language translation; myocardial remodeling; necropsy; novel; novel marker; outcome forecast; pathway; patient population; phosphoric diester hydrolase; postmortem; pressure; prognostic; programs; prostaglandin X; pulmonary; pulmonary arterial hypertension; randomized controlled study; response; sildenafil; social role; success; tissue culture; transplant; vascular",RIGHT VENTRICULO-PULMONARY VASCULAR COUPLING IN PAH,,84946,ZHL1,Special Emphasis Panel,,4,,374479
8013838,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,0003,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"WIGLEY, FREDRICK M;",6319386;,5P50HL084946,,,"92-kDa Gelatinase; 92-kDa Type IV Collagenase; Address; Angiogenic Factor; Angiostatin; Angiostatins; Antibodies; Arts; Assay; Attention; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; Autologous Antigens; Automobile Driving; B23; Bioassay; Biologic Assays; Biological Assay; Blood Circulation; Blood Plasma; Blood Sample; Blood Vessels; Blood Volume; Blood specimen; Bloodstream; Body Tissues; COL18A1; Cell-Extracellular Matrix; Cells; Cessation of life; Circulation; Cleaved cell; Clinical; Collaborations; Cor pulmonale; Cytoplasmic Granules; Data; Death; Development; Disease; Disorder; Drivings, Automobile; Dysfunction; EC 3.4.21.7; ECM; Endostatins; Endothelial Cells; Esteroproteases; Extracellular Matrix; FBN1; Factor, Angiogenesis; Functional disorder; Gelatinase B; Granzyme; Hypertension, Pulmonary; Image; Immune; Inflammatory; Infrastructure; Injury; Investigators; Kringles 1-4 of Plasminogen; Laboratories; Lead; Leiomyocyte; Link; Lung; Lymphocyte; Lymphocytic; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Matrix Metalloproteinase-9; Measurement; Measures; Mediating; Molecular; Morphology; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NPM; NPM1; NPM1 gene; NUMATRIN; Nested Case-Control Study; Outcome; Pathologic Processes; Pathological Processes; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Phenotype; Physiopathology; Plasma; Plasminogen; Play; Population; Predisposition; Process; Profibrinolysin; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Pulmonary Artery; Pulmonary Heart Disease; Pulmonary Heart Disorder; Pulmonary Hypertension; Pulmonary artery structure; Recruitment Activity; Research Infrastructure; Research Personnel; Researchers; Respiratory System, Lung; Reticuloendothelial System, Serum, Plasma; Risk; Role; Scleroderma; Sclerosis, Systemic; Self-Antigens; Serum, Plasma; Site; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Specificity; Study, Nested Case-Control; Susceptibility; Systemic Scleroderma; Time; Tissues; Tube; Type V Collagenase; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular remodeling; Vegf; angiogenesis; autoimmune antibody; biomarker; blood vessel disorder; cardiopulmonary disease; cardiopulmonary disorder; cleaved; clinical phenotype; cohort; cytotoxic; cytotoxic serine protease B; dermatosclerosis; design; designing; disease/disorder; driving; fibrillarin; fibrillin-1; fragmentin 2; gene product; granule; granzyme B; heavy metal Pb; heavy metal lead; hemodynamics; imaging; in vivo; inflammatory marker; injury and repair; interest; lymph cell; molecular pathology; new diagnostics; next generation diagnostics; novel diagnostics; pathophysiology; pathway; programs; progressive systemic sclerosis; prospective; pulmonary; pulmonary arterial hypertension; recruit; repair; repaired; self reactive antibody; self recognition (immune); social role; tool; vascular",DYSREGULATED ANGIOGENESIS IN SCLERODERMA-ASSOCIATED PAH,,84946,ZHL1,Special Emphasis Panel,,4,,435049
8013839,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,0004,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"JOHNS, ROGER A;",1883543;,5P50HL084946,,,"20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Active Oxygen; Adeno-Associated Viruses; Angiotensins; Animal Model; Animal Models and Related Studies; Binding; Binding (Molecular Function); Blood Vessels; Blood monocyte; Candidate Disease Gene; Candidate Gene; Cardiac Myocytes; Cardiac Remodeling, Ventricular; Cardiocyte; Causality; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cellular Migration; Cellular Proliferation; Cessation of life; Chronic; Clinical; Co-Stimulator; Common Rat Strains; Complex; Costimulator; Cytokines, Chemotactic; Death; Dependovirus; Development; Disease; Disorder; Endothelial Cells; Endothelin; Endothelium-Derived Vasoconstrictor Factors; Enteramine; Epidermal Thymocyte Activating Factor; Etiology; Event; GFAC; Generalized Growth; Generations; Genes; Genomics; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HTRPY; Heart; Heart Hypertrophy; Heart failure; Heart myocyte; Hippophaine; Homologous Chemotactic Cytokines; Human; Human, General; Hyperplasia; Hyperplastic; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; Hypoxic; IL-2; IL2; IL2 Protein; INFLM; Inflammation; Inflammatory; Intercrines; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Leiomyocyte; Lesion; Lung; Lymphocyte Mitogenic Factor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Mice; Mitogenic Factor; Mitogenic Factor Receptors; Modeling; Molecular; Molecular Interaction; Monocrotaline; Motility; Motility, Cellular; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial Remodeling, Ventricular; Myocytes, Cardiac; Myocytes, Smooth Muscle; Names; Oxygen Deficiency; Oxygen Radicals; Patients; Physiologic; Physiological; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Pro-Oxidants; Process; Production; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteomics; Pulmonary Hypertension; Pulmonary vessels; Rat; Rattus; Reactive Oxygen Species; Receptor Inhibition; Receptors, Mitogenic Factor; Recombinants; Recruitment Activity; Respiratory System, Lung; Right Ventricular Hypertrophy; Right ventricular structure; Role; SIS cytokines; Scleroderma; Serotonin; Signal Pathway; Simvastatin; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Synvinolin; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; Thymocyte Stimulating Factor; Tissue Growth; VEGFs; Vascular Endothelial Growth Factors; Vascular constriction (function); Vascular remodeling; Vasoconstriction; Vegf; Ventricle Remodeling; Ventricles, Right; Ventricular Remodeling; adeno associated virus group; analog; base; cardiac failure; cardiac hypertrophy; cardiomyocyte; cell motility; chemoattractant cytokine; chemokine; cytokine; dermatosclerosis; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; in vivo; macrophage; model organism; monocyte; myocardial remodeling; novel; ontogeny; prevent; preventing; pulmonary; pulmonary arterial hypertension; recruit; research study; sildenafil; social role; vascular; vasculogenesis",HIMF/FIZZ1 IN PULMONARY HYPERTENSION/RIGHT HEART FAILURE,,84946,ZHL1,Special Emphasis Panel,,4,,446446
8013840,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,0005,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"CROW, MICHAEL T.;",1933122;,5P50HL084946,,,"21+ years old; 3-mononitrotyrosine; 3-nitrotyrosine; 5,6,7,8-tetrahydrobiopterin; Actin Filaments; Active Oxygen; Adult; Affect; Animal Model; Animal Models and Related Studies; Animals; Arteries; Arts; Autoregulation; BH4; BPH4; Bioavailability; Biologic Availability; Biological Availability; Blood Coagulation Factor IV; Blood Vessels; Blood capillaries; Body Tissues; CNOS; Ca++ element; Calcium; Capillaries; Capillary; Capillary, Unspecified; Cardiac; Cardiac Myocytes; Cardiac Output; Cardiac Remodeling, Ventricular; Cardiocyte; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-Extracellular Matrix; Chromosome Substitution Strain; Chromosomes; Chronic; Clinical; Coagulation Factor IV; Collaborations; Common Rat Strains; Consomic Strain; Consomic Strain/Chromosome Substitution Strain; Constitutive NOS; Coupled; Coupling; Cyclic GMP; Data; Development; Distal; Dysfunction; ECM; ECNOS; ENOS; Effectiveness; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Exposure to; Expression Profiling; Expression Signature; Extracellular Matrix; FLR; Factor IV; Failure (biologic function); Fetal Liver Kinase-1; Fibrosis; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Functional disorder; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Generalized Growth; Generations; Genes; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Transcription; Genetic analyses; Goals; Growth; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); H4B; H4biopterin; HTRPY; Heart; Heart Hypertrophy; Heart failure; Heart myocyte; Homeostasis; Human; Human Resources; Human, Adult; Human, General; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; Hypoxic; Individual; Inherited Predisposition; Inherited Susceptibility; Intracellular Communication and Signaling; Investigators; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Left Ventricles; Left ventricular structure; Lesion; Lung; Mammals, Rats; Man (Taxonomy); Man, Modern; Manpower; Medial; Microfilaments; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocardial; Myocardial Remodeling, Ventricular; Myocytes; Myocytes, Cardiac; Myofilaments; NOS Type III; NOS3; NOS3 gene; NOS3 protein, human; NOSIII; Nature; Nitric Oxide Synthase 3; Norway; Oral; Oxidative Stress; Oxygen Deficiency; Oxygen Radicals; PDE; PDE 5 enzyme; Pathway interactions; Patients; Performance; Peripheral; Phosphodiesterases; Physiologic; Physiologic Availability; Physiological; Physiological Homeostasis; Physiopathology; Population; Predisposition; Pressure; Pressure- physical agent; Preventive; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Proteomics; Pulmonary Artery; Pulmonary Hypertension; Pulmonary artery structure; QTL; Quantitative Trait Loci; RNA Expression; Rat; Rat Strains; Rattus; Reactive Oxygen Species; Receptor Signaling; Reporting; Research Personnel; Researchers; Respiratory System, Lung; Right Ventricular Dysfunction; Right Ventricular Hypertrophy; Right ventricular structure; Right-On; Rodent Model; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Staging; Stress; Survey Instrument; Surveys; Susceptibility; THBP; Testing; Therapeutic; Time; Tissue Growth; Tissues; Transcript; Transcription; Transcription, Genetic; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptors; VEGFR; VEGFR-2; VEGFR2; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vascular remodeling; Vegf; Ventricle Remodeling; Ventricles, Right; Ventricular; Ventricular Dysfunction, Right; Ventricular Remodeling; adult human (21+); base; bioavailability of drug; biological signal transduction; biomarker; cGMP; calcium flux; calcium mobilization; capillary; cardiac failure; cardiac hypertrophy; cardiomyocyte; consomic; dimer; eNOS enzyme; endothelial constitutive nitric oxide synthase; failure; fetal; genetic analysis; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome-wide; guanosine 3'5' monophosphate; heart output; hemodynamics; human NOS3 protein; inhibitor; inhibitor/antagonist; insight; intercellular communication; model organism; molecuar profile; molecular signature; myocardial remodeling; nitrotyrosine; novel; ontogeny; pathophysiology; pathway; personnel; phosphodiesterase V; phosphodiesterase-5; phosphoric diester hydrolase; pressure; prevent; preventing; programs; pulmonary; pulmonary arterial hypertension; release of sequestered calcium ion into cytoplasm; resistant strain; response; salt sensitive; sildenafil; social role; stressor; tetrahydro-6-biopterin; tetrahydrobiopterin; vascular",Determinants of Right Heart Failure In Severe PAH,,84946,ZHL1,Special Emphasis Panel,,4,,406999
8013841,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,9001,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"TUDER, RUBIN M;",1869247;,5P50HL084946,,,"Abscission; Animals; Arteries; Arts; Autopsy; Behavior; Biopsy; Blood Vessels; Body Tissues; Candidate Disease Gene; Candidate Gene; Cardiopulmonary; Cataloging; Catalogs; Cell Components; Cell Structure; Cells; Cellular Structures; Clinical; Complement; Complement Proteins; Complex; Cyclic GMP; DISSEC; Data; Disease; Disease Marker; Disease Pathway; Disease Progression; Disorder; Dissection; Effectiveness; Electromagnetic, Laser; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Excision; Experimental Designs; Experimental Genetics; Experimental Models; Experimental Models, Other; Extirpation; FLR; Failure (biologic function); Future; Gene Expression; Gene Transcription; Genes; Genetic Markers; Genetic Transcription; Genetics, in situ Hybridization; Genomics; Genotype; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Heart; Heart Muscle tissue; Histology; Human; Human, General; Hypertension, Pulmonary; In Situ Hybridization; Injury; Intervention; Intervention Strategies; Investigation; Investigators; Lasers; Lead; Learning; Light; Lung; Lung Neoplasms; Lung Parenchyma; Lung Tissue; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Method LOINC Axis 6; Methodology; Microdissection; Microscopic; Models, Experimental; Molecular; Molecular Genetic; Molecular Genetics; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial tissue; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Pathologist; Pathway interactions; Patients; Pattern; Pb element; Phenotype; Photoradiation; Play; Population; Preparation; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Pulmonary Artery; Pulmonary Hypertension; Pulmonary Neoplasms; Pulmonary Pathology; Pulmonary artery structure; Qualifying; RNA Expression; Radiation, Laser; Removal; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Right Ventricular Dysfunction; Risk; Role; Scleroderma; Severities; Site; Staging; Structure; Structure of parenchyma of lung; Surgical Removal; Time; Tissues; Transcript; Transcription; Transcription, Genetic; Translating; Translatings; Translations; Tumor of the Lung; VEGFs; Validation; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular remodeling; Vegf; Ventricular; Ventricular Dysfunction, Right; angiogenesis; base; biomarker; blood vessel disorder; cGMP; dermatosclerosis; design; designing; disease phenotype; disease/disorder; endothelial cell derived relaxing factor; experience; experiment; experimental research; experimental study; failure; flexibility; gene product; guanosine 3'5' monophosphate; heavy metal Pb; heavy metal lead; improved; in situ Hybridization Staining Method; interventional strategy; language translation; molecular pathology; necropsy; novel; pathway; postmortem; pressure; programs; pulmonary; pulmonary arterial hypertension; research study; resection; social role; tissue processing; tool; vascular",CORE--MOLECULAR PATHOLOGY,,84946,ZHL1,Special Emphasis Panel,,4,,336631
8013842,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,9002,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"BARNES, KATHLEEN C;",1865958;,5P50HL084946,,,"Acute Pulmonary Injury; Address; Alleles; Allelomorphs; American; Analysis, Data; Animal Model; Animal Models and Related Studies; Antigen-Antibody Complex; Apoptosis; Apoptosis Pathway; Arts; Assay; Asthma; Atopic Dermatitis; Attention; Belief; Bioassay; Biologic Assays; Biological; Biological Assay; Blood Clotting; Blood Vessels; Blood coagulation; Blotting, Northern; Body Tissues; Bronchial Asthma; Candidate Disease Gene; Candidate Gene; Cardiac Remodeling, Ventricular; Cardiology; Cardiovascular Disease (Specialty); Cataloging; Catalogs; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Proliferation; Characteristics; Clinical; Clinical Services; Common Rat Strains; Communication; Communities; Complement; Complement Proteins; Complex; Contracting Opportunities; Contracts; Core Facility; DNA; DNA Library; DNA bank; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Dermatitis, Atopic; Development; Diagnostic; Disease; Disease Marker; Disorder; Dysfunction; E-Mail; Eczema, Atopic; Electronic Mail; Email; Ensure; Ethnic group; European; Expression Profiling; Expression Signature; FLR; Failure (biologic function); Financial Management; Foundations; Frequencies (time pattern); Frequency; Functional disorder; Funding; Gene Cluster; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Products, RNA; Gene Proteins; Genes; Genetic; Genetic Algorithm; Genetic Medicine; Genetic Polymorphism; Genetic Programming; Genetic Research; Genomics; Genotype; Goals; Heart; Hereditary; Human; Human, General; Image; Immune; Immune Complex; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Inflammatory; Inflammatory Response; Information Technology; Inherited; Institutes; Intermediary Metabolism; Investigation; Investigators; Laboratories; Link; Lung; Lung Injury, Acute; Lung diseases; METBL; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical center; Medicine; Messenger RNA; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Mice; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Myocardial Remodeling, Ventricular; NIH; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institutes of Health (U.S.); Network Analysis; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; Northern Blotting; Northern Blottings; Occupational activity of managing finances; Oligo; Oligonucleotide Array; Oligonucleotide Microarrays; Oligonucleotides; Pathology; Pathway Analysis; Patients; Pattern; Phenotype; Physiologic; Physiological; Physiopathology; Play; Pneumology; Pneumonology; Polymorphism (Genetics); Polymorphism Analysis; Polymorphism Detection; Polymorphism, Genetic; Polymorphism, Single Base; Position; Positioning Attribute; Predisposition; Preparation; Principal Investigator; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Protein Gene Products; Proteomics; Pulmonary Disease (Specialty); Pulmonary Diseases; Pulmonary Disorder; Pulmonary Medicine; Pulmonology; Quality Control; RNA; RNA blot analysis; RNA blotting; RNA, Messenger; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Rat; Rattus; Regulatory Pathway; Research; Research Personnel; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reverse Transcriptase Polymerase Chain Reaction; Rheumatology; Ribonucleic Acid; Right Ventricular Dysfunction; Right ventricular structure; Role; SNP; SNPs; Sampling; Scanning; Science of Medicine; Scientist; Scleroderma; Sentinel; Sepsis; Services; Severities; Severity of illness; Single Nucleotide Polymorphism; Solutions; Staining method; Stainings; Stains; Susceptibility; System; System, LOINC Axis 4; Technology; Testing; Therapeutic Clinical Trial; Time; Tissue Extracts; Tissue Sample; Tissues; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Vaccinia; Validation; Variant; Variation; Vascular remodeling; Ventilator; Ventricle Remodeling; Ventricles, Right; Ventricular Dysfunction, Right; Ventricular Remodeling; acute lung injury; allergic dermatitis; allergic eczema; angiogenesis; base; biomarker; bloodstream infection; clinical data repository; clinical data warehouse; clinical phenotype; cohort; cost; data repository; density; dermatosclerosis; design; designing; disease severity; disease/disorder; experiment; experimental research; experimental study; failure; genetic epidemiology; genetic resource; genetic technology; high risk; human disease; human subject; human tissue; imaging; innovate; innovation; innovative; insight; laboratory facility; lung disorder; lung injury; mRNA; meetings; microarray technology; model organism; molecuar profile; molecular signature; mouse model; myocardial remodeling; new approaches; novel; novel approaches; novel strategies; novel strategy; pathophysiology; patient population; polymorphism; programs; protein expression; pulmonary; pulmonary arterial hypertension; relational database; research facility; research study; reverse transcriptase PCR; social role; success; trait; translation research enterprise; vascular; web site",CORE--GENOMICS AND GENOTYPING,,84946,ZHL1,Special Emphasis Panel,,4,,572343
8013843,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,9003,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"VAN EYK, JENNIFER E;",7940252;,5P50HL084946,,,"2-dimensional; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Address; Affinity Chromatography; Amino Acids; Animal Model; Animal Models and Related Studies; Area; Arts; Automobile Driving; Award; Binding; Binding (Molecular Function); Bio-Informatics; Bioinformatics; Biopsy; Biopsy Sample; Biopsy Specimen; Blood Cells; Blood Serum; Blood Vessels; Body Tissues; Cardiac; Cardiac Myocytes; Cardiac Remodeling, Ventricular; Cardiocyte; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Models; Cardiovascular system; Cardiovascular system (all sites); Cell model; Cells; Cellular model; Chemicals; Chromatography, Affinity; Collaborations; Common Rat Strains; Complement; Complement Proteins; Complex; Computer Simulation; Computerized Models; Country; Coupled; Cytokine Signal Transduction; Cytokine Signaling; Cytokines, Chemotactic; Data; Detection; Development; Disease; Disorder; Doctor of Philosophy; Drivings, Automobile; Drugs; Electrophoresis; Equipment; FBN1; FIZZ1 protein, mouse; FLR; Faculty; Failure (biologic function); Foundations; Fractionation, Electrophoretic; Gelatinase B; Genetic; Genome; Genomics; Genotype; Goals; Grant; HIMF; Heart; Heart myocyte; Homologous Chemotactic Cytokines; Human; Human, General; Hypoxia; Hypoxic; Image; Immune Precipitation; Immunoassay; Immunoprecipitation; Infrastructure; Intercrines; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Isoforms; LC/MS; Label; Leadership; Left; Liquid Chromatography; Lung; Lung Parenchyma; Lung Tissue; Lung diseases; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mathematical Model Simulation; Mathematical Models and Simulations; Matrix Metalloproteinase-9; Measurement; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metals; Modeling; Models, Cardiovascular; Models, Computer; Modification; Molecular; Molecular Interaction; Multiple Partners; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocardial Ischemia; Myocardial Remodeling, Ventricular; Myocytes; Myocytes, Cardiac; NIH; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institutes of Health (U.S.); Organ System, Cardiovascular; Oxygen Deficiency; Partners, Multiple; Pathway interactions; Peripheral Blood Cell; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphorylation; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Production; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; Pulmonary Diseases; Pulmonary Disorder; R01 Mechanism; R01 Program; RELMalpha protein, mouse; RELMalpha, mouse; RPG; Rat; Rattus; Relative; Relative (related person); Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Retnla protein, mouse; Right lung; Right ventricular structure; Right-On; Rodent; Rodentia; Rodentias; Role; SIS cytokines; Sampling; Schools, Medical; Scientist; Scleroderma; Serum; Services; Side; Simulation, Computer based; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure of parenchyma of lung; System; System, LOINC Axis 4; Technology; Temperature; Therapeutic Intervention; Time; Tissue Sample; Tissues; Type V Collagenase; United States National Institutes of Health; VEGFs; Vascular Endothelial Growth Factors; Vascular, Heart; Vegf; Ventricle Remodeling; Ventricles, Right; Ventricular; Ventricular Remodeling; Work; affinity purification; aminoacid; base; biomarker; cardiomyocyte; chemoattractant cytokine; chemokine; circulatory system; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cytokine; cytotoxic serine protease B; dermatosclerosis; disease/disorder; driving; drug/agent; experience; failure; fibrillin-1; fragmentin 2; gel electrophoresis; gene product; granzyme B; heart ischemia; hypoxia-induced mitogenic factor , mouse; imaging; in silico; interest; intervention therapy; liquid chromatography mass spectrometry; lung disorder; medical schools; member; model organism; molecular pathology; mouse model; mouse resistin-like alpha; myocardial ischemia/hypoxia; myocardial remodeling; myocardium ischemia; novel; novel marker; paracrine; pathway; programs; protein complex; pulmonary; pulmonary arterial hypertension; resistin like alpha protein, mouse; resistin-like alpha, mouse; skills; social role; tool; two-dimensional; vascular; virtual simulation",CORE--PROTEOMICS,,84946,ZHL1,Special Emphasis Panel,,4,,585371
8013844,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,9004,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"BLUEMKE, DAVID A.;",1932622;,5P50HL084946,,,"Blood Vessels; Cardiac; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Data; Deterioration; Disease; Disease Marker; Disorder; Echocardiogram; Echocardiography; Evaluation; FLR; Failure (biologic function); Fibrosis; Goals; Human Resources; INFLM; Image; Imaging Procedures; Imaging Techniques; Inflammation; Infrastructure; Lung; Lung diseases; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Manpower; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Molecular; Mortality; Mortality Vital Statistics; Myocardial; Myocardial depression; Myocardial dysfunction; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Organ System, Cardiovascular; Patients; Phenotype; Pressure; Pressure- physical agent; Proteomics; Pulmonary Artery; Pulmonary Diseases; Pulmonary Disorder; Pulmonary artery structure; Research Infrastructure; Research Resources; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Right Ventricular Dysfunction; Right Ventricular Function; Right ventricular structure; Scleroderma; Serologic; Serological; Services; Structure; Technics, Imaging; Testing; Transthoracic Echocardiography; Validation; Vascular, Heart; Ventricles, Right; Ventricular; Ventricular Dysfunction, Right; Ventricular Function, Right; Zeugmatography; base; biomarker; cardiovascular function; circulatory system; dermatosclerosis; design; designing; detector; disease/disorder; experience; failure; heart sonography; imaging; imaging modality; lung disorder; novel; personnel; pressure; pulmonary; pulmonary arterial hypertension; pulmonary function; sound measurement; vascular",CORE--IMAGING,,84946,ZHL1,Special Emphasis Panel,,4,,287215
8013845,P50,HL,5,,01/01/2010,12/31/2010,,5P50HL084946-04,9005,,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HASSOUN, PAUL M;",1885391;,5P50HL084946,,,"Accounting; Budgets; Communication; Ensure; Expenditure; Fostering; Grant; Human Resources; Investigators; Manpower; Molecular; Monitor; National Heart, Lung, and Blood Institute; Programs (PT); Programs [Publication Type]; Regulation; Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Services; Universities; Work; base; computerized data processing; data processing; high standard; meetings; personnel; programs; pulmonary arterial hypertension; signal processing",Administrative,,84946,ZHL1,Special Emphasis Panel,,4,,117150
7760583,P50,NS,5,,02/01/2010,01/31/2011,,5P50NS035902-13,,NINDS:1062840;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,NEUROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"FERRIERO, DONNA M.;",6113692;,5P50NS035902,04/01/1998,01/31/2013,,Mechanisms of Ischemic Neonatal Brain Injury,,35902,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,13,1062840,
7745502,P60,AA,5,,12/01/2009,11/30/2010,AA-07-003,5P60AA003510-33,,NIAAA:1781472;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,PSYCHIATRY,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"HESSELBROCK, VICTOR M;",1882156;,5P60AA003510,03/01/1978,11/30/2012,,Etiology and Treatment of Alcohol Dependence,,3510,ZAA1,Special Emphasis Panel,,33,1781472,
8014954,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"BAUER, LANCE O.;",1865693;,5P60AA003510,,,"21+ years old; Adolescent; Adolescent Youth; Adult; After Care; After-Treatment; Aftercare; Alcohol dependence; Attention; Behavior Therapy, Cognitive; Behavioral Therapy; Brain; Candidate Disease Gene; Candidate Gene; Causality; Clinical; Cognitive Therapy; Comorbidity; Conduct Disorder; DSM-IV; DSM4; Data; Dependence; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Dysfunction; EEG; Electroencephalography; Emotional Depression; Encephalon; Encephalons; Equation; Ethanol dependence; Etiology; Event-Related Potentials; Exhibits; FLR; Failure (biologic function); Functional disorder; Genetic; Genetic Processes; Genotype; Goals; Heavy Drinking; History; Human, Adult; Individual; Judgment; Laboratories; Link; Literature; Longitudinal Studies; Manuals; Marijuana Smoking; Measures; Mental disorders; Mental health disorders; Methods and Techniques; Methods, Other; Modeling; Motivation; Nervous System, Brain; Neurobiology; Outcome; Participant; Patients; Physiopathology; Population; Preparedness; Process; Psychiatric Disease; Psychiatric Disorder; Psychotherapy, Cognitive; Public Health; Readiness; Recording of previous events; Relative; Relative (related person); Reporting; Research; Risk Assessment; Risk Estimate; Risk Factors; SUBGP; Science of neurophysiology; Self Efficacy; Severities; Subgroup; Symptoms; Symptoms of depression; Techniques; Therapy, Cognition; Treatment Failure; Treatment Period; Treatment outcome; Unspecified Mental Disorder; Youth; Youth 10-21; Youth Drinking; adolescent alcohol use; adolescent drinking; adolescents with alcohol use disorders; adult human (21+); alcohol addiction; alcohol dependency; alcohol response; alcohol use disorder; alcohol-dependent; base; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; depressive; depressive symptoms; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drink heavily; drinking; endophenotype; ethanol addiction; ethanol dependency; ethanol response; ethanol use disorder; ethanol-dependent; event related potential; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; failure; heavy alcohol use; high risk; improved; juvenile; juvenile human; long-term study; meetings; mental illness; neurobiological; neurophysiology; pathophysiology; psychologic; psychological; psychological disorder; public health medicine (field); response to alcohol; response to ethanol; success; teen drinking; teenage drinking; treatment days; treatment duration; underage drinking",Component II: Predicting Treatment Outcome in Adolescent AUD,,3510,ZAA1,Special Emphasis Panel,,33,,245419
8014955,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0002,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"TENNEN, HOWARD ;",6252671;,5P60AA003510,,,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; 5HT transporter; 5HTT protein; Address; Affect; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Belief; Candidate Disease Gene; Candidate Gene; Causality; DNA; Data Collection; Deoxyribonucleic Acid; Dependence; Diathesis; Disease susceptibility; Enteramine; Environment; EtOH drinking; Ethanol dependence; Etiology; Event; Family; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genotype; Head and Neck, Saliva; Hippophaine; Inherited Predisposition; Inherited Susceptibility; Internet; Learning; Life; Link; Measures; Memory; Methods and Techniques; Methods, Other; Modeling; Motivation; Outcome; Pattern; Polymorphism (Genetics); Polymorphism, Genetic; Population; Preventive; Process; Reporting; Risk Factors; Role; Saliva; Serotonin; Stress; Symptoms; System; System, LOINC Axis 4; Techniques; Time; University drinking; WWW; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; base; college drinking; college student; coping; disease causation; disease etiology; disease/disorder etiology; disease/disorder proneness/risk; disorder etiology; drinking; drinking behavior; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; experience; genetic etiology; genetic mechanism of disease; genetic risk factor; genetic vulnerability; hazardous alcohol use; inherited factor; innovate; innovation; innovative; liability to disease; polymorphism; problem drinking; response; serotonin transporter; social; social role; sodium-dependent serotonin transporter; stressor; university student; web; world wide web",Component III: Stress Related College Drinking: Learned and Genetic Vulnerabiliti,,3510,ZAA1,Special Emphasis Panel,,33,,285683
8014956,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0003,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"PETRY, NANCY M;",1886384;,5P60AA003510,,,"AIDS Virus; AOD use; Abstinence; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Affect; After Care; After-Treatment; Aftercare; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Causality; Characteristics; Chemical Class, Alcohol; Clinic; Communities; Conditioning Therapy; Dependence; Drug usage; Drugs; Drugs, Illicit; EtOH drinking; Ethanol dependence; Etiology; Exposure to; Goals; HIV; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Illicit Drugs; Individual; Intervention; Intervention Strategies; Intervention Studies; Investigation; LAV-HTLV-III; Length; Life Style Modification; Lymphadenopathy-Associated Virus; Measures; Medical; Medication; Motivation; Negative Reinforcements; Out-patients; Outcome; Outpatients; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prize; Probability; Procedures; Psychological reinforcement; QOL; Quality of life; Randomized; Reinforcement; Reinforcement (Psychology); Reinforcements, Negative; Relative; Relative (related person); Research; Risk Behaviors; Risky Behavior; Sampling; Services; Severities; Substance abuse problem; Sum; Symptoms; Time; Treatment Period; Treatment outcome; United States; Veterans; Virus-HIV; Work; abuse of substances; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; at risk behavior; base; behavior change; behavior intervention; behavioral intervention; brief intervention; contingency management; cost; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drinking; drug use; drug/agent; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol use disorder; ethanol-dependent; etoh use; follow-up; hazardous alcohol use; improved; interventional strategy; problem drinking; psychosocial; randomisation; randomization; randomly assigned; reduced alcohol use; reinforcer; response; standard care; substance abuse; substance use; treatment as usual; treatment days; treatment duration",Component IV: Contingency Managment Treatment Duration,,3510,ZAA1,Special Emphasis Panel,,33,,283401
8014957,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0004,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"KRANZLER, HENRY RICHARD;",1873404;,5P60AA003510,,,"(5-L-Glutamyl)-peptide[{..}]amino-acid 5-glutamyltransferase; 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Active Follow-up; Adverse effects; After Care; After-Treatment; Aftercare; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholic; Alcoholic beverage heavy drinker; Alcohols; Aminalon; Aminalone; Biological; Boozer; Butanoic acid, 4-amino-; Causality; Chemical Class, Alcohol; Dependent drinker; Drugs; EtOH drinking; Ethanol dependence; Etiology; Evaluation Studies; Expectancy; GABA; GGT; GGTP; Gamma-GT; Gamma-glutamyl transferase; General Population; General Public; Genes; Glutamate Receptor; Glutamyl Transpeptidase; Heavy Drinker; Heavy Drinking; High Prevalence; Linear Models; Measures; Medication; Moods; NIAAA; National Institute on Alcohol Abuse and Alcoholism; PBO; Patient Self-Report; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Dependence; Placebos; Randomized; Safety; Self-Report; Sham Treatment; Technology; Therapeutic; Treatment Side Effects; Variant; Variation; Voice; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; disease causation; disease etiology; disease/disorder etiology; disorder etiology; dosage; drink heavily; drinking; drinking behavior; drug/agent; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; follow-up; gamma glutamyltranspeptidase; gamma-Aminobutyric Acid; gamma-Glutamyl Transpeptidase; gamma-Glutamyltransferase; gammaglutamyltransferase; heavy alcohol use; patient population; problem drinker; randomisation; randomization; randomly assigned; response; sham therapy; side effect; therapy adverse effect; topiramate; treatment adverse effect; trial comparing; week trial",Component V: Topiramante Treatment of Problem Drinkers,,3510,ZAA1,Special Emphasis Panel,,33,,255247
8014958,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0005,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"BABOR, THOMAS F;",6126973;,5P60AA003510,,,"Activities, Educational; Administrator; Alcohol dependence; Alcoholism; Attention; Awareness; Awarenesses; Books; Causality; Clinical; Collaborations; Communities; Connecticut; Consensus; Consultations; Continuance of education; Continuing Education; Development; Development and Research; Distance Learning; Education, Continuing; Educational Activities; Educational process of instructing; Educational workshop; Elements; Ethanol dependence; Ethics; Etiology; Faculty; Foundations; Genetic; Health Services; International; Investigators; Journals; Learning, Distance; Magazine; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Publications; Publishing; R & D; R&D; Research; Research Associate; Research Personnel; Researchers; Science; Scientific Publication; Services; Societies; Strategic Planning; Substance Abuse Treatment Centers; Teaching; Technology; Training; Translational Research; Translational Research Enterprise; Translational Science; Work; Workshop; addiction; alcohol addiction; alcohol dependency; alcohol research; alcohol screening; alcohol-dependent; base; brief intervention; conference; disease causation; disease etiology; disease/disorder etiology; disorder etiology; ethanol addiction; ethanol dependency; ethanol research; ethanol-dependent; graduate student; health care service; improved; post-doc; post-doctoral; programs; research and development; research to practice; screening and brief intervention; symposium; translation research enterprise",Component VI: Translational Dissemination and Educational Activities Related to A,,3510,ZAA1,Special Emphasis Panel,,33,,161271
8014959,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,0006,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"HESSELBROCK, VICTOR M;",1882156;,5P60AA003510,,,"2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Applications Grants; Area; Basic Research; Basic Science; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Causality; Dental; Development; Drug Therapy; EtOH drinking; Ethanol dependence; Etiology; Exercise; Exercise, Physical; Funding; Future; Grant Proposals; Grants, Applications; Individual; K-Awards; K-Series Research Career Programs; Medicine; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pharmacotherapy; Pilot Projects; Procedures; Programs (PT); Programs [Publication Type]; Publications; Research; Research Career Program; Research Career Programs, K-Series; Review Committee; Risk; Role; Schools, Medical; Science of Medicine; Scientific Publication; Staging; Stress; United States National Institutes of Health; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; base; college student; disease causation; disease etiology; disease/disorder etiology; disorder etiology; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; hazardous alcohol use; interest; medical schools; meetings; pilot study; problem drinking; programs; sedentary; social role; topiramate; university student",Component VII: Pilot Studies,,3510,ZAA1,Special Emphasis Panel,,33,,63697
8014960,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA003510-33,9001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,FARMINGTON,UNITED STATES,,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"HESSELBROCK, VICTOR M;",1882156;,5P60AA003510,,,"ARHGEF5; ARHGEF5 gene; Alcohol dependence; Alcohols; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Budgets; Causality; Chemical Class, Alcohol; Clinical; Clinical Research; Clinical Study; Connecticut; Consultations; Continuance of education; Continuing Education; Core Facility; Development; Editorial; Editorial (PT); Editorial [Publication Type]; Education, Continuing; Education, Professional; Equipment; Ethanol dependence; Etiology; Evaluation; GEF5; Genotype; Goals; Grant; Human Resources; Information Management; Investigators; Journals; Magazine; Manpower; Mentors; Mission; P60; Population; Postdoc; Postdoctoral Fellow; Principal Investigator; Professional Education; Quality Control; Rain; Research Activity; Research Associate; Research Personnel; Research Resources; Researchers; Resource Allocation; Resource Sharing; Resources; Role; Schools, Medical; Scientist; Site; TIM; TIM1; Training; Universities; Visit; alcohol addiction; alcohol dependency; alcohol research; alcohol-dependent; authority; data management; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; editorial; ethanol addiction; ethanol dependency; ethanol research; ethanol-dependent; laboratory facility; medical schools; new technology; personnel; post-doc; post-doctoral; public policy on alcohol; social role; statistics/biometry",Component I: Administrative and Scientific Cores,,3510,ZAA1,Special Emphasis Panel,,33,,486754
7745497,P60,AA,5,,12/01/2009,11/30/2010,AA-07-003,5P60AA006282-28,,NIAAA:1564398;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,Beltsville,UNITED STATES,,05,021883350,US,MD,207053111,PACIFIC INSTITUTE FOR RES AND EVALUATION,"GRUENEWALD, PAUL J;",1909936;,5P60AA006282,09/29/1983,11/30/2012,,Environmental Approaches to Prevention,,6282,ZAA1,Special Emphasis Panel,,28,1564398,
7754435,P60,AA,5,,01/01/2010,12/31/2010,AA-07-003,5P60AA006420-27,,NIAAA:1807505;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"KOOB, GEORGE F;",1881505;,5P60AA006420,12/01/1983,12/31/2012,,CNS Effects of Alcohol: Cellular Neurobiology,,6420,ZAA1,Special Emphasis Panel,,27,1807505,
7745503,P60,AA,5,,12/01/2009,11/30/2010,AA-07-003,5P60AA007611-23,,NIAAA:1792590;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,12/01/1989,11/30/2012,,Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol,,7611,ZAA1,Special Emphasis Panel,,23,1792590,
8015960,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0012,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Acquired brain injury; Affect; Alcohol Drinking; Alcohol consumption; Alcohols; Binding Sites; Bio-Informatics; Bioinformatics; Biological Factors; Brachydanio rerio; Brain; Brain Injuries; Chemical Class, Alcohol; Child Development Disorders, Specific; Combining Site; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Danio rerio; Defect; Development; Developmental Delay; Developmental Delay Disorders; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Dysmorphology; Embryo; Embryonic; Encephalon; Encephalons; EtOH drinking; Exposure to; Expression Profiling; Expression Signature; FASD; Face; Factor, Biologic; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal ETOH Exposure; Fetal Ethanol Exposure; Fetal alcohol effects; Functional disorder; Gene Expression; Generalized Growth; Genes; Genetic; Genetic Determinism; Genetics, in situ Hybridization; Gestation; Goals; Goltz-Gorlin syndrome; Growth; Hour; In Situ Hybridization; In Utero Alcohol Exposure; In Utero ETOH Exposure; In Utero Ethanol Exposure; Inbred Mouse; Inbred Strain; Individual Differences; Informatics; Intervention; Intervention Strategies; Knowledge; Link; Mammals, Mice; Mice; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Natural Products; Nervous; Nervous System, Brain; Neural Development; Ortholog; Orthologous Gene; Outcome; Pathogenesis; Pathway interactions; Pattern; Physiopathology; Predisposition; Pregnancy; Prenatal Alcohol Exposure; Prenatal ETOH Exposure; Prenatal Ethanol Exposure; Reactive Site; Risk; Screening procedure; Susceptibility; Technology; Tissue Growth; Variant; Variation; Zebra Danio; Zebra Fish; Zebrafish; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol response; alcohol use; alcohol-exposed pregnancy; alcoholic beverage consumption; alcoholic drink intake; alcoholic embryopathy; brain damage; brain lesion (from injury); cohort; drinking; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol use; etoh use; exposed to alcohol; exposed to alcohol prenatally; exposure to alcohol; facial; fetal alcohol syndrome (FAS); genetic determinant; gestation ETOH exposure; gestation alcohol exposure; gestation ethanol exposure; in situ Hybridization Staining Method; insight; interventional strategy; loss of function; molecuar profile; molecular signature; mouse model; neural; neural patterning; neurobehavioral; neurodevelopment; novel; ontogeny; pathophysiology; pathway; pregnancy ETOH exposure; pregnancy alcohol exposure; pregnancy ethanol exposure; prenatal alcohol effect; prenatally alcohol exposed; prenatally exposed to alcohol; relating to nervous system; response to alcohol; response to ethanol; screening; screenings; transcription factor",Genetics of FAS in Mouse Component,,7611,ZAA1,Special Emphasis Panel,,23,,156655
8015961,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0013,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Activities, Educational; Adoption; Africa; Alcohol Drinking; Alcohol Laws; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Alleles; Allelomorphs; Behavioral Genetics; Brain region; Chemical Class, Alcohol; Clinical; Clinical Research; Clinical Study; Collaborations; Communities; Continuance of education; Continuing Education; Country; Dependence; Diagnosis; Drug abuse; Education; Education, Continuing; Educational Activities; Educational aspects; Educational process of instructing; Ensure; Environment; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Faculty; Family Medical History; Family history of; Feeding behaviors; Fetal Alcohol Syndrome; Funding; Genetic Determinants of Behavior; Genetic Determinism; Genetics, Behavioral; Goals; Goltz-Gorlin syndrome; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; History; Indiana; Individual; Ingestive Behavior; Institution; Justice; Knowledge; Laboratories; Laws; Length of Life; Longevity; Medical Students; Minority; Minority-Serving Institution; Neurobiology; North Carolina; Policy Maker; Population; Postdoc; Postdoctoral Fellow; Prevention; Programs (PT); Programs [Publication Type]; Provincial Government; Public Policy; Recording of previous events; Research; Research Associate; Research Training; Risk; School Health Nursing; School Nursing; Schools; Social Service; Social Work; Social work (field); Special Population; State Government; Students; Students, Medical; Substance abuse problem; System; System, LOINC Axis 4; Teaching; Textbooks; Translational Research; Translational Research Enterprise; Translational Science; Universities; Variant; Variation; abuse of drugs; abuse of substances; abuses drugs; alcohol abuse therapy; alcohol abuse treatment; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol related problem; alcohol research; alcohol response; alcohol treatment; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholic embryopathy; alcoholism treatment; base; behavior genetics; conference; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol response; ethanol use; ethanol-dependent; etoh use; evidence base; feeding-related behaviors; fetal alcohol syndrome (FAS); genetic determinant; hazardous alcohol use; improved; life span; lifespan; mRNA Expression; named group; neurobiological; nutrient intake activity; post-doc; post-doctoral; problem drinking; programs; public health relevance; response to alcohol; response to ethanol; science education; substance abuse; symposium; translation research enterprise",Translational Research and Science Education Component,,7611,ZAA1,Special Emphasis Panel,,23,,73074
8015962,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0014,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Abstinence; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Assay; Behavioral; Bioassay; Biologic Assays; Biological Assay; BrAC; Brain; Chemical Class, Alcohol; Disinhibition; Drug Kinetics; Encephalon; Encephalons; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Eye Movements; Family Medical History; Family history of; Functional Magnetic Resonance Imaging; Future; Genes; Genetic; Genetic Determinism; Genotype; Goals; Grant; Human; Human, General; Individual; Intervention; Intervention Strategies; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Methods; Motor; Nervous System, Brain; Oral; Pharmacokinetics; Research; Risk; Risk Factors; Symptoms; Time; Variant; Variation; alcohol addiction; alcohol breath analysis; alcohol dependency; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol related problem; alcohol response; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; assay of breath alcohol; assay of breath ethanol; behavioral disinhibition; breath alcohol concentration; breath alcohol measurement; breath alcohol test; breath ethanol concentration; breath ethanol measurement; breath ethanol test; endophenotype; ethanol addiction; ethanol breath analysis; ethanol consumption; ethanol dependency; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol use; ethanol use disorder; ethanol-dependent; etoh use; exposed to alcohol; exposure to alcohol; fMRI; frontal cortex; frontal lobe; genetic determinant; high risk; interventional strategy; response to alcohol; response to ethanol",GABRA2 & the Pharmacokinetics of Risk for Alcoholism Component,,7611,ZAA1,Special Emphasis Panel,,23,,378526
8015963,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0015,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Absolute ethanol; Abstinence; Acute; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Animals; Arts; Behavior; Breeding; Cell Communication and Signaling; Cell Signaling; Characteristics; Chemical Class, Alcohol; Chronic; Code; Coding System; Common Rat Strains; Complex; DNA Molecular Biology; Differential Gene Expression; ETOH; EtOH drinking; Ethanol; Gene Expression; Genes; Genetic Determinism; Genomics; Grain Alcohol; Indiana; Individual; Intracellular Communication and Signaling; Mammals, Rats; Mediating; Methods and Techniques; Methods, Other; Methylcarbinol; Molecular; Molecular Biology; Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurocyte; Neurons; Nucleus Accumbens; Pharmacological Treatment; Procedures; Production; Proteins; Rat; Rattus; Relapse; Research; Self Administration; Self-Administered; Signal Transduction; Signal Transduction Systems; Signaling; Synaptic plasticity; Techniques; Testing; Therapeutic; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Ventral Tegmental Area; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol relapse; alcohol research; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; biological signal transduction; drinking behavior; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol relapse; ethanol research; ethanol response; ethanol use; etoh use; exposed to alcohol; exposure to alcohol; gene product; genetic determinant; mesolimbic system; neurobiological; neuronal; preference; receptor function; response; response to alcohol; response to ethanol; ventral tegmentum",CNS Genetic Determinants of Alcohol Drinking in Rats Component,,7611,ZAA1,Special Emphasis Panel,,23,,235723
8015964,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0016,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Absolute ethanol; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcoholic; Alcohols; Animals; Area; Boozer; Breeding; Chemical Class, Alcohol; Cocaine; Common Rat Strains; Dependent drinker; Dopamine; Drugs; ETOH; EtOH drinking; Ethanol; Exposure to; Genetic; Genetic Determinism; Genetic Research; Goals; Grain Alcohol; Human; Human, General; Hydroxytyramine; IARC; Individual; Intake; International Agency for Research on Cancer; Locomotor Activity; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medication; Methylcarbinol; Motor Activity; Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurocyte; Neurons; Nicotine; Nucleus Accumbens; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Predisposition; Production; Psychological reinforcement; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reinforcement; Reinforcement (Psychology); Relapse; Research; Susceptibility; Testing; Ventral Tegmental Area; abused drugs; alcohol effect; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol response; alcohol seeking; alcohol seeking behavior; alcohol use; alcoholic beverage consumption; alcoholic drink intake; drinking; drug of abuse; drug/agent; drugs abused; drugs of abuse; ethanol abuse; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol seeking; ethanol use; ethanol-seeking behavior; etoh use; genetic determinant; hazardous alcohol use; insight; neurobiological; neuronal; preference; problem drinker; problem drinking; response; response to alcohol; response to ethanol; treatment effect; ventral tegmentum",Genetic Determinants of Alcohol Preference & Actions of Drugs of Abuse Component,,7611,ZAA1,Special Emphasis Panel,,23,,98830
8015965,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,0017,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Advisory Committees; Alcohol Drinking; Alcohol consumption; Area; Country; EXTMR; EtOH drinking; Extramural; Extramural Activities; Funding; Funding Mechanisms; Generalized Growth; Genetic Determinism; Growth; Indiana; Investigators; Method LOINC Axis 6; Methodology; Performance; Pilot Projects; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Senior Scientist; Task Forces; Tissue Growth; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol response; ethanol use; etoh use; flexibility; genetic determinant; innovate; innovation; innovative; ontogeny; pilot study; programs; response to alcohol; response to ethanol; success",Pilot Project Component,,7611,ZAA1,Special Emphasis Panel,,23,,96082
8015966,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,9001,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"3'5'-cyclic ester of AMP; AP Endonuclease Class I; AP Lyase; AP endonuclease, human; APE1; APEN; APEN protein, human; APEX Nuclease; APEX Nuclease (Multifunctional DNA Repair Enzyme); APEX nuclease (multifunctional DNA repair enzyme) 1, human; APEX nuclease, human; APEX-1 protein, human; APEX1; APEX1 protein, human; APX; Absolute ethanol; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Alcohols; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animals; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anxiolytic Agents; Anxiolytics; Apurinic/Apyrimidinic (Abasic) Endonuclease; Apurinic/Apyrimidinic Exonuclease; Behavioral; Binding; Binding (Molecular Function); Breeding; Cell Nucleus; Chemical Class, Alcohol; Chromosome 4; Chromosomes, Human, Pair 4; Common Rat Strains; Cyclic AMP; Deoxyribonuclease (Apurinic or Apyrimidinic); Development; Disease; Disorder; Drugs; ETOH; Elements; EtOH drinking; Ethanol; Foundations; Funding; Gene Expression; Genetic Determinism; Genome; Goals; Grain Alcohol; Grant; HAP1; HAP1 DNA repair enzyme, human; HAP1 protein, human (nuclease); Human; Human, General; Indiana; Investigators; Lod Score; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medication; Methylcarbinol; Mice; MoAb R24; Modeling; Molecular Interaction; Monoclonal Antibody R24; Multifunctional DNA Repair Enzyme; Murine; Mus; NIAAA; NIH; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Institutes of Health (U.S.); Neurochemistry; Neuropeptide Tyrosine; Nucleus; Pharmaceutic Preparations; Pharmaceutical Preparations; Production; QTL; Quantitative Trait Loci; R-24 Monoclonal Antibody; R24; REF-1; REF1; Rat; Rattus; Ref-1 protein, human; Relapse; Research; Research Personnel; Research Resources; Researchers; Resources; Rewards; Rodent; Rodentia; Rodentias; Science of neurochemistry; Scientific Advances and Accomplishments; Training; Tranquilizing Agents, Minor; United States National Institutes of Health; adenosine 3'5' monophosphate; adolescent alcohol abuse; alcohol effect; alcohol ingestion; alcohol intake; alcohol preferring mice; alcohol product use; alcohol research; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; antianxiety agent; base; binge alcohol consumption; binge drinking; cAMP; congenic; craving; deprivation; disease/disorder; drinking; drug/agent; episodic drinking; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol perferring mice; ethanol product use; ethanol research; ethanol response; ethanol use; etoh use; genetic determinant; human APEX1 protein; model organism; neurochemistry; neuropeptide Y; offspring; preference; redox factor 1, human; ref1 protein, human; response to alcohol; response to ethanol; scientific accomplishments; scientific advances; success",Animal Production Core,,7611,ZAA1,Special Emphasis Panel,,23,,443628
8015967,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,9002,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Agents, Muscarinic; Alcohol Drinking; Alcohol consumption; Alcoholism; Alcohols; Allele Frequency; Animal Model; Animal Models and Related Studies; Animals; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Candidate Disease Gene; Candidate Gene; Chemical Class, Alcohol; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Common Rat Strains; Cost Savings; DBA/2 Mouse; DNA Molecular Biology; Development; Differential Gene Expression; Disease; Disorder; Embryo; Embryonic; Enzymes; EtOH drinking; Fetal Alcohol Syndrome; Future; GABA Receptor; Gene Cluster; Gene Frequency; Genes; Genetic; Genetic Determinism; Genomics; Genotype; Goals; Goltz-Gorlin syndrome; Haplotypes; Heavy Drinking; Human; Human, General; Indiana; Laboratories; Mammals, Rats; Man (Taxonomy); Man, Modern; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular Biology; Monitor; Muscarinics; Pathway interactions; Phenotype; Pilot Projects; Production; R01 Mechanism; R01 Program; RPG; Rat; Rat Strains; Rattus; Receptors, ACh; Receptors, Acetylcholine; Receptors, gamma-Aminobutyric Acid; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; SNP genotyping; Saving, Cost; Services; System; System, LOINC Axis 4; Technology; Time; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol monitoring; alcohol product use; alcohol research; alcohol response; alcohol seeking; alcohol seeking behavior; alcohol use; alcoholic beverage consumption; alcoholic drink intake; alcoholic embryopathy; allelic frequency; critical period; disease/disorder; drink heavily; drinking; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol response; ethanol seeking; ethanol use; ethanol-seeking behavior; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; exposed to alcohol; exposure to alcohol; extreme drinking; fetal alcohol syndrome (FAS); genetic determinant; heavy alcohol use; microarray technology; model organism; pathway; pilot study; prevent; preventing; response to alcohol; response to ethanol",Genomics and Molecular Biology Core,,7611,ZAA1,Special Emphasis Panel,,23,,162163
8015968,P60,AA,5,,12/01/2009,11/30/2010,,5P60AA007611-23,9007,,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CRABB, DAVID W;",1872785;,5P60AA007611,,,"Advisory Committees; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Applications Grants; Attorneys; Chemical Class, Alcohol; Collaborations; Communities; Country; DNA Molecular Biology; Data; Development; EXTMR; Educational Materials; Educational workshop; EtOH drinking; Ethanol dependence; Extramural; Extramural Activities; Fetal Alcohol Syndrome; Financial Support; Fostering; Funding; Genes; Genetic Determinism; Genetics, Human; Genomics; Goltz-Gorlin syndrome; Grant Proposals; Grants, Applications; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare worker; Human Genetics; IARC; Image; Indiana; Individual; International Agency for Research on Cancer; Investigators; Knowledge; Laboratories; Lawyers; Leadership; Link; Medical Students; Molecular Biology; Monitor; Neurobiology; Nurses; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Personnel Management; Personnel, Nursing; Physicians; Pilot Projects; Programs (PT); Programs [Publication Type]; Public Health; Publishing; Research; Research Personnel; Researchers; Risk; Role; Schools; Science; Scientist; Social Workers; Source; Students, Medical; Surgical; Surgical Interventions; Surgical Procedure; Task Forces; Translational Research; Translational Research Enterprise; Translational Science; Travel; Universities; Workers, Social; Workshop; alcohol abuse therapy; alcohol abuse treatment; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol research; alcohol response; alcohol treatment; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholic embryopathy; alcoholism treatment; base; career development; conference; cost; craving; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol response; ethanol use; ethanol-dependent; etoh use; fetal alcohol syndrome (FAS); genetic determinant; hazardous alcohol use; health care personnel; health care worker; health provider; healthcare personnel; imaging; medical personnel; member; neurobiological; outreach; pilot study; preference; problem drinking; programs; public health medicine (field); public health relevance; response to alcohol; response to ethanol; science education; social role; surgery; symposium; translation research enterprise; treatment provider; web site",Administrative Core,,7611,ZAA1,Special Emphasis Panel,,23,,147909
7754443,P60,AA,5,,01/01/2010,12/31/2010,AA-05-001,5P60AA010760-15,,NIAAA:1789795;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"CRABBE, JOHN C.;",1868301;,5P60AA010760,12/01/1996,12/31/2010,,Behavioral Genomics of Alcohol Neuroadaptation,,10760,ZAA1,Special Emphasis Panel,,15,1789795,
7745504,P60,AA,5,,12/01/2009,11/30/2010,AA-07-003,5P60AA011605-13,,NIAAA:1807807;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"CREWS, FULTON T;",1896910;,5P60AA011605,12/01/1997,11/30/2012,,Molecular and Cellular Pathogenesis in Alcoholism,,11605,ZAA1,Special Emphasis Panel,,13,1807807,
7790557,R00,AR,5,,01/01/2010,12/31/2010,,5R00AR054775-04,,NIAMS:246276;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HORSLEY, VALERIE ;",8667424;,5R00AR054775,04/01/2009,12/31/2011,"Acne Vulgaris; Active Follow-up; Affect; Applications Grants; Award; Biology; Cancers; Cell Growth in Number; Cell Lineage; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Clinical; Commit; Communication; Cutaneous Disorder; Data; Dermatoses; Development; Disease; Disorder; Drugs; Epidermis; Epithelial; Genes; Goals; Grant Proposals; Grants, Applications; Hair Follicle; Hair follicle structure; Human; Human, General; Hyperplasia; Hyperplastic; Lead; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medication; Mentors; Mother Cells; Pathology; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Production; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Regulation; Role; Sebaceous Glands; Sebum; Sebums; Skin; Skin Diseases; Skin Diseases and Manifestations; Stem cells; Testing; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; disease/disorder; drug/agent; experiment; experimental research; experimental study; follow-up; gland development; heavy metal Pb; heavy metal lead; human disease; in vivo; keratinocyte; malignancy; mutant; neoplasm/cancer; novel; premature; progenitor; research study; skin disorder; social role; therapeutic development; tumor",Regulation of Sebaceous Gland Development,,54775,NSS,,,4,246276,
7790729,R00,DA,5,,02/01/2010,01/31/2011,PA-07-297,5R00DA023548-04,,NIDA:246510;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,PSYCHIATRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"HERIN, DAVID VANCE;",8791759;,5R00DA023548,04/01/2009,01/31/2012,"21+ years old; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Abuse, Amphetamine; Addiction, Cocaine; Adoption; Adult; Agonist; Amphetamine Abuse; Amphetamines; Applications Grants; Award; Benzeneethanamine, alpha-methyl-, (S)-; Bp50; CD40; CDW40; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Collaborations; Communities; Data; Dependences, Cocaine; Development; Dexamfetamine; Dexedrine; Dextroamphetamine; Disease; Disorder; Doctor of Philosophy; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Precursors; Drug Targeting; Drug Targetings; Drugs; FDA approved; Faculty; Formulation; Formulations, Drug; Functional Imaging; Funding Agency; Funding Source; Future; Genetics, Human; Grant Proposals; Grants, Applications; Health Sciences; Human Genetics; Human, Adult; Impulsivity; Individual; Kinetic; Kinetics; Laboratory Study; Literature; MGC9013; Measures; Medication; Minnesota; Modeling; Movement; NIDA; National Institute of Drug Abuse; PBO; Pathway interactions; Patients; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Physiologic Imaging; Placebos; Population; Position; Positioning Attribute; Preparation; Pro-Drugs; Probability; Prodrugs; Property; Property, LOINC Axis 2; Psychiatry; Public Health; RFP; Request for Proposals; Research; Resistance; Risk; Secure; Sham Treatment; Societies; Statistical Methods; Substance abuse problem; TNFRSF5; TNFRSF5 gene; Technology; Texas; Training; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Universities; Urinary System, Urine; Urine; Work; abuse of substances; adult human (21+); analog; body movement; career; clinical investigation; cocaine use; craving; d-Amphetamine; dextro-Amphetamine; disease/disorder; drug/agent; experience; innovate; innovation; innovative; p50; pathway; public health medicine (field); resistant; responsible research conduct; sham therapy; skills; substance abuse; treatment strategy",Lisdexamfetamine treatment for cocaine dependence,"Cocaine dependence is a significant public health problem, and there are no approved medications to treat  this disorder. As an extension of our previous work, the current study will investigate the ability of the abuseresistant  medication Lisdexamfetamine to treat cocaine dependence.",23548,NSS,,,4,246510,
7770838,R00,DE,5,,02/01/2010,01/31/2011,PA-06-133,5R00DE018400-04,,NIDCR:246509;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,OKLAHOMA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"KRETH, JENS ;",8771063;,5R00DE018400,02/16/2009,01/31/2012,"Address; Atomic Force Microscope; Atomic Force Microscopy; Biological Models; Caries; Causality; Cell Communication and Signaling; Cell Signaling; Dental Decay; Dental Plaque; Dental caries; Development; Etiology; Exclusion; Expression Profiling; Expression Signature; Force Microscopy; Gene Expression; Generalized Growth; Genes; Growth; HA coating; Head and Neck, Saliva; Individual; Intracellular Communication and Signaling; Investigation; Metabolic; Microbial Biofilms; Microscopy, Atomic Force; Model System; Modeling; Models, Biologic; Molecular Fingerprinting; Molecular Profiling; Outcome; Pathogenicity Factors; Phase; Research; Role; S. mutans; S.mutans; Saliva; Scanning Force Microscopy; Signal Transduction; Signal Transduction Systems; Signaling; Streptococcus mutans; Testing; Tissue Growth; Virulence; Virulence Factors; abstracting; base; biofilm; biological signal transduction; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; hydroxyapatite coating; molecuar profile; molecular signature; ontogeny; oral bacteria; oral biofilm; oral flora; oral streptococci; response; social role; tooth decay",Interspecies Streptococcal Antagonisms in Oral Biofilms,,18400,NSS,,,4,246509,
7769879,R00,DK,5,,02/01/2010,01/31/2011,,5R00DK077505-04,,NIDDK:249000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,INDIANAPOLIS,UNITED STATES,BIOCHEMISTRY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"DONG, XIAOCHENG CHARLIE;",8626725;,5R00DK077505,02/15/2009,01/31/2012,"Acetyl CoA; Acetyl Coenzyme A; Adenoviridae; Adenoviruses; Alanine; Alanine, L-Isomer; Animal Model; Animal Models and Related Studies; Area; Autoregulation; Blood Glucose; Blood Sugar; Cell Communication and Signaling; Cell Signaling; Chemotherapy-Hormones/Steroids; Coenzyme A, S-acetate; D-Glucose; D-Glucose-6-phosphate phosphohydrolase; Development; Dextrose; Diabetes Mellitus; Diabetic mouse; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7; Endocrine Gland Secretion; Epidemic; Fatty Acids; Future; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; GeneHomolog; Genes; Genetic; Gluconeogenesis; Glucose; Glucose-6-Phosphate Phosphohydrolase; Goals; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Homeostasis; Homolog; Homologous Gene; Homologue; Hormonal; Hormones; Humulin R; Hyperglycemia; INSR; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Signaling Pathway; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Investigation; Ketosuccinates; Kinases; Knockout Mice; L-Alanine; Lead; Liver; Liver Cells; Mammals, Mice; Mediating; Metabolic; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Normal Range; Normal Values; Novolin R; Null Mouse; Nutrient; Nutritional; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); Oxaloacetates; Oxosuccinates; PDH kinase; PDK4 enzyme; PEPCK; Pathogenesis; Pb element; Phase; Phenotype; Phosphoenolpyruvate Carboxylase; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Play; Principal Investigator; Process; Protein Phosphorylation; Pyruvate; Pyruvate Dehydrogenase Complex; Pyruvate Metabolism; Pyruvate Metabolism Pathway; Pyruvates; RNA, Small Interfering; Reagent; Regulation; Relative; Relative (related person); Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Starvation; System; System, LOINC Axis 4; Testing; Therapeutic Hormone; Time; Transphosphorylases; Work; biological signal transduction; blood glucose regulation; body system, hepatic; design; designing; detection of nutrient; diabetes; diabetes mellitus therapy; diabetes therapy; diabetic; driving force; glucose RA; glucose biosynthesis; glucose control; glucose homeostasis; glucose metabolism; glucose production; glucose rate of appearance; glucose regulation; glucose-6-phosphatase; heavy metal Pb; heavy metal lead; hepatic gluconeogenesis; hyperglycemic; improved; in vitro Assay; in vivo; insight; model organism; mouse model; mouse model of diabetes; nutrient sensing; organ system, hepatic; oxidation; perception of nutrients; phosphoenolpyruvate carboxykinase; pyruvate dehydrogenase kinase; pyruvate dehydrogenase kinase 4; reagent testing; response; siRNA; social role",Role of Pyruvate Dehydrogenase Kinases in Glucose Homeostasis,"The goal of this project is to elucidate the mechanism how blood glucose levels are elevated above a normal  range in the development of diabetes, which has reached an epidemic level in the U.S. and worldwide.",77505,NSS,,,4,249000,
7769875,R00,DK,5,,02/01/2010,01/31/2011,PA-06-133,5R00DK080080-04,,NIDDK:249000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOULDER,UNITED STATES,BIOCHEMISTRY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"SHEN, JINGSHI ;",8910428;,5R00DK080080,02/15/2009,01/31/2012,"ATP-protein phosphotransferase; Address; Adipocytes; Adipose Cell; Adipose tissue; Affect; Assay; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biology; Biosynthetic Proteins; Bizzozero's corpuscle/cell; Blood Coagulation Factor IV; Blood Platelets; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Ca++ element; Calcium; Cell Function; Cell Process; Cell fusion; Cell membrane; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Coagulation Factor IV; Complex; Cytoplasmic Membrane; Deetjeen's body; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; EC 2.7; EFF; Endocrine Gland Secretion; Environment; Enzymes; Epidemic; Epithelial; Exhibits; Exocytosis; Factor IV; Fat Cells; Fatty Tissue; Glucose Binding Protein; Glucose Transporter; Goals; Hand; Hayem's elementary corpuscle; Hormones; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Signaling Pathway; Insulin, Regular; Isoforms; Kinases; Kinetic; Kinetics; Knock-out; Knockout; Knowledge; Label; Lead; Light; Lipocytes; Liposomal; Liposomes; Lung; MODY; Marrow platelet; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Membrane; Membrane Fusion; Modification; Molecular; Molecular Interaction; Molecular Mechanisms of Action; Munc-18 protein; Munc18 protein; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Myocytes; NIDDM; NSF attachment protein receptor; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Outcome; Pathway interactions; Pb element; Peptides; Phenotype; Phosphotransferases; Photoradiation; Physiologic; Physiological; Plasma Membrane; Platelets; Process; Property; Property, LOINC Axis 2; Protein Family; Protein Isoforms; Protein Kinase; Proteins; Reaction; Recombinant Proteins; Regulation; Regulatory Pathway; Regulatory Protein; Research; Respiratory System, Lung; Reticuloendothelial System, Platelets; Role; SNAP receptor; SNARE; Specificity; Staging; Stxbp4 protein, mouse; Subcellular Process; Synapses; Synaptic; Synip protein, mouse; System; System, LOINC Axis 4; T2D; T2DM; Testing; Therapeutic Hormone; Therapeutic Intervention; Thrombocytes; Time; Transphosphorylases; Transport Protein, Glucose; Type 2 diabetes; Type II diabetes; VESCL; Vesicle; Work; adipose; adult onset diabetes; base; blood glucose regulation; combinatorial; diabetes; effusion; gene product; genetic regulatory protein; glucose control; glucose homeostasis; glucose regulation; glucose uptake; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; insight; insulin signaling; intervention therapy; ketosis resistant diabetes; maturity onset diabetes; membrane structure; mouse Stxbp4 protein; neuronal; new therapeutic target; novel; pathway; phosphorylase b kinase kinase; plasmalemma; pulmonary; reconstitute; reconstitution; regulatory gene product; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; synaptotagmin; synip; syntaxin 4; syntaxin binding protein 1; syntaxin binding protein 4, mouse; syntaxin binding protein Munc18; syt (synaptotagmin); thrombocyte/platelet; white adipose tissue; yellow adipose tissue",Regulation of GLUT4 Exocytosis,,80080,NSS,,,4,249000,
7753212,R00,EB,5,,01/01/2010,12/31/2010,PA-06-133,5R00EB007241-04,,NIBIB:246026;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,RIVERSIDE,UNITED STATES,ENGINEERING (ALL TYPES),07,627797426,US,CA,92521,UNIVERSITY OF CALIFORNIA RIVERSIDE,"PARK, BORIS HYLE;",8668403;,5R00EB007241,01/01/2009,12/31/2011,"Action Potentials; Address; Animals; Area; Award; Behavior; Biological Neural Networks; Biomedical Engineering; California; Cell Count; Cell Number; Cells; Chemicals; Collaborations; Coloring Agents; Common Rat Strains; Complement; Complement Proteins; Contrast Agent; Contrast Drugs; Contrast Media; Cranial Nerve II; Crossmatching, Tissue; Detection; Development; Doppler OCT; Dyes; Educational process of instructing; Electrodes; Electrophysiology; Electrophysiology (science); Eye; Eyeball; Faculty; Fiber; Foundations; Funding; Future; Goals; Hand; Histocompatibility Testing; Horseshoe Crabs; Image; In Vitro; Individual; Interferometry; Investigators; Lateral; Lead; Light; Limulus; Limulus polyphemus; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rats; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mentors; Methods; Methods and Techniques; Methods, Other; NMR Imaging; NMR Tomography; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Neurosciences; Neurosciences Research; Nuclear Magnetic Resonance Imaging; OCT Tomography; Optic Nerve; Optical Coherence Tomography; Optical Methods; Optics; Pb element; Phase; Photoradiation; Physics; Physiologic; Physiological; Position; Positioning Attribute; Process; R01 Mechanism; R01 Program; RPG; Radiopaque Media; Rat; Rattus; Receptor Protein; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Research Training; Researchers; Resolution; Retina; Sciatic Nerve; Second Cranial Nerve; Structure; Structure of sciatic nerve; Supervision; Swelling; Teaching; Techniques; Technology; The Sun; Thick; Thickness; Time; Tissue Crossmatchings; Tissue Typing; Tomography, Optical Coherence; Training; Universities; Visual System; Visual system structure; Work; Xiphosura; Zeugmatography; base; bioengineering; bioengineering/biomedical engineering; bioimaging; bioimaging/biomedical imaging; biomedical imaging; clinical applicability; clinical application; compound eye; experience; heavy metal Pb; heavy metal lead; histocompatibility typing; imaging; in vitro activity; in vivo; minimally invasive; myelination; nano meter scale; nano meter sized; nano scale; nanometer scale; nanometer sized; nanoscale; neural; neural network; neuronal; novel; optic imaging; optical imaging; receptor; relating to nervous system; sciatic nerve",Optical Detection of Neural Activity With Phase Sensitive Interferometry,,7241,NSS,,,4,246026,
7775027,R00,HL,5,,02/01/2010,01/31/2011,,5R00HL087513-04,,NHLBI:249000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,PATHOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"MAHONEY, WILLIAM M;",7301036;,5R00HL087513,02/23/2009,01/31/2012,"Address; Affect; Animals; Antibodies; Arteries; Assay; Back; Beds; Bioassay; Biologic Assays; Biological Assay; Biology; Blood Pressure; Blood Pressure, High; Blood Vessels; Blood flow; CHIP assay; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; ChIP (chromatin immunoprecipitation); Complex; Coupled; Cysteine; Data; Development; Disease; Disorder; Dorsum; Elements; Exons; Family member; G(s), alpha Subunit; G(s)alpha; G-Protein Regulating Factors; G-Protein, Gs alpha Family; G-Protein, Stimulatory Gs; G-Proteins; G-substrate; GTP-Binding Protein Regulators; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Products, RNA; Gene Transcription; Genes; Genes, LacZ; Genetic Transcription; Genome; Genome, Human; Goals; Grant; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HTRPY; Half-Cystine; Heart; Human Genome; Hypertension; Hypertrophy; Immunologic, Luciferase; In Vitro; Individual; Injury; Intracellular Communication and Signaling; Investigation; Knockout Mice; L-Cysteine; Laboratories; LacZ; LacZ Genes; Leiomyocyte; Luciferases; Mammals, Mice; Mentors; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Models, Molecular; Molecular; Molecular Models; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Myocytes, Smooth Muscle; Ns Protein, Regulatory; Nucleic Acid Biochemistry, Molecular Modeling; Null Mouse; Organ System, Cardiovascular; Pathologic; Pattern; Phase; Physiologic; Physiological; Physiology; Pressure; Pressure- physical agent; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; RGS Family Protein; RGS Protein (G-Protein Signaling); RGS Proteins; RNA; RNA Expression; RNA, Messenger; RNA, Non-Polyadenylated; Regulating Factors, GTP-Binding Protein; Regulation; Regulators of G-Protein Signaling Proteins; Regulators, G-Protein Signaling; Relative; Relative (related person); Research; Ribonucleic Acid; Role; SM 22 muscle protein; SM22 alpha; SM22 alpha protein; SM22 muscle protein; Sequence Homology; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Stimulatory GTP-Binding Protein, alpha Subunit; Testing; Tg (protein); Transcript; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenic Animals; Transgenic Mice; Trees; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular constriction (function); Vascular remodeling; Vascular, Heart; Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Veins; alpha-Gs; base; biological signal transduction; career; cell type; cerebellum protein substrate for cGMP dependent protein kinase; chromatin immunoprecipitation; circulatory system; constriction; cultured cell line; disease/disorder; experiment; experimental research; experimental study; feeding; gene product; hemodynamics; homology (molecular); hyperpiesia; hyperpiesis; hypertensive disease; in vivo; injury response; interest; mRNA; mRNA Expression; member; microarray technology; molecular modeling; overexpression; pressure; programs; protein G; protein expression; protein function; receptor coupling; receptor function; research study; response; response to injury; social role; transcription factor; transgelin; vascular; vascular bed; vasopressor",Molecular Characterization of Arterially-Restricted RGS5,,87513,NSS,,,4,249000,
7753876,R00,HL,5,,01/01/2010,12/31/2010,PA-06-133,5R00HL087560-04,,NHLBI:249000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"DESHPANDE, DEEPAK A;",8634755;,5R00HL087560,12/01/2006,12/31/2011,"3'5'-cyclic ester of AMP; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; ATP phosphohydrolase (Ca(2+)-transporting); Acute; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine Triphosphatase, Calcium; Adenosine, cyclic 3',5'-(hydrogen phosphate); Agonist; Aspiration, Respiratory; Asthma; Attenuated; Biochemical; Biology; Blood Coagulation Factor IV; Body Tissues; Breathing; Bronchial Asthma; Bronchial Spasm; Bronchospasm; Ca(2+)-Transporting ATPase; Ca++ element; Ca2+ ATPase; Ca2+ transporting ATPase; Calcium; Calcium ATPase; Calcium Adenosinetriphosphatase; Calcium Pump; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Coagulation Factor IV; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Development; Dinoprostone; Disease; Disorder; Dose; Ectopic Expression; Endoplasmic Reticulum; Ergastoplasm; Event; Factor IV; Generations; Genes; Genotype; Human; Human, General; IC50; Infection; Inhalation; Inhaling; Inhibitory Concentration 50; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Inspiration, Respiratory; Intracellular Communication and Signaling; Ion Channels, Potassium; Isoprenaline; Isopropyl Noradrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isuprel; K channel; Knock-out; Knockout; Leiomyocyte; Lentivirinae; Lentivirus; Lung Diseases, Obstructive; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Method LOINC Axis 6; Methodology; Mice; Molecular; Molecular Target; Murine; Mus; Muscle Cell Contraction; Muscle Contraction; Muscle Relaxation; Muscle Tension; Muscle relaxants; Muscle relaxation phase; Muscle, Involuntary; Muscle, Smooth; Muscular Contraction; Muscular Tension; Myocytes, Smooth Muscle; Obstructive Lung Diseases; Organ Culture; Organ Culture Techniques; Outcome; PGE2; PGE2 alpha; PGE2alpha; PKA; Pathway interactions; Peptides; Phase; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphoproteins; Phosphorylation; Physiology; Potassium Channel; Prevention Measures; Process; Prophylactic treatment; Prophylaxis; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Protein Kinase A; Protein Phosphorylation; Proteins; Proteome; PtdIns; Regulation; Relative; Relative (related person); Relaxation; Research; Rho-associated kinase; Rho-kinase; Ryanodine; Ryanodol, 3-(1H-pyrrole-2-carboxylate); Series; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Subfamily lentivirinae; Tachyphylaxis; Tissues; Transgenic Organisms; Variant; Variation; Vasodilating Agent; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Virus-Lenti; Work; adenosine 3'5' monophosphate; airway smooth muscle; base; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; calcium flux; calcium mobilization; calcium transporting ATPase; disease/disorder; effective therapy; experiment; experimental research; experimental study; functional genomics; gene product; human tissue; improved; insight; inspiration; methacholine; new approaches; new therapeutics; next generation therapeutics; novel approaches; novel strategies; novel strategy; novel therapeutics; obstructive airway disease; obstructive lung disease (generalized); pathway; phase 1 study; phase 2 study; phospholamban; primary outcome; release of sequestered calcium ion into cytoplasm; research study; respiratory airway obstruction; respiratory smooth muscle; tool; transgenic",Molecular Mechanisms of Airway Smooth Muscle Relaxation,Studies proposed in the application identify molecular targets of the airway smooth muscle relaxant agents  that are used as first line of therapy in airway obstructive diseases such as asthma. The findings may help  develop newer and better smooth muscle relaxants for the use in airway diseases.,87560,NSS,,,4,249000,
7758743,R00,HL,5,,01/01/2010,12/31/2010,PA-06-133,5R00HL087561-04,,NHLBI:248999;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,PATHOLOGY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"SILVA, RANASINGHE ;",8656707;,5R00HL087561,01/12/2009,12/31/2011,"Affect; Apo A-2; Apo A-II; Apo A2; Apo AII; Apo-A; ApoA; ApoA-2; ApoA-II; Apolipoprotein A-2; Apolipoprotein A-II; Apolipoprotein A2; Apolipoprotein AII; Apolipoproteins; Apolipoproteins A; Assay; Benchmarking; Best Practice Analysis; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Cardiovascular Diseases; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Esters; Cholesteryl Esters; Choline Glycerophospholipids; Choline Phosphoglycerides; Complex; Deuterium; Deuterium Oxide; Digestion; Disease; Disorder; EC 2; Goals; H element; H2 isotope; HDL; Heavy Lipoproteins; Heavy Water; High Density Lipoproteins; High density lipoprotein; Human; Human, General; Hybrids; Hydrogen; INCO receptor; In Vitro; Intermediary Metabolism; Lead; Lecithin; Life; Lipase; Lipids; Lipoproteins; Lipoproteins, HDL; METBL; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mentors; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Monitor; Pb element; Phase; Phosphatidylcholines; Photometry/Spectrum Analysis, Mass; Plasma; Play; Process; Property; Property, LOINC Axis 2; Proteins; Reaction; Receptor Protein; Relative; Relative (related person); Resolution; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Site; Solvents; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spinal Column; Spine; Staging; Structure; Techniques; Testing; Transferase; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triolean Hydrolase; Vertebral column; Water-d2; Work; alpha-Lipoproteins; backbone; base; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; comparative; conformation; conformational state; cubilin; cubulin; disease/disorder; experiment; experimental research; experimental study; fighting; gene product; heavy metal Pb; heavy metal lead; hepatic lipase; insight; intrinsic factor-cobalamin receptor; new therapeutic target; new therapeutics; next generation therapeutics; novel therapeutic intervention; novel therapeutics; particle; receptor; reconstitute; reconstitution; research study; social role; time interval; tributyrase; vitamin B12-intrinsic factor receptor",The role of apolipoprotein A-II in the modulation of HDL function,"HDL and its major protein component apoA-l have been shown to play a major beneficial role in decreasing  the risk of cardiovascular disease. However, the current understanding of functional roles of apoA-ll, the  second major protein in HDL is at a basic level. Our proposal that focuses on apoA-ll modulation of apoA-l-  HDL fijnction will provide important new infomriation on the stmcture-fundion correlations and may form the  basis for new therapeutic targets for enhancing HDL protective function.",87561,NSS,,,4,248999,
7766250,R00,HL,5,,02/01/2010,01/31/2011,PA-07-297,5R00HL088317-05,,NHLBI:249000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"DEB, ARJUN ;",8674160;,5R00HL088317,02/01/2008,01/31/2011,"21+ years old; Academic Medical Centers; Adult; Affect; Apoptosis; Apoptosis Pathway; Assay; Autocrine Systems; Bears; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; CD117 Antigens; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac Failure Congestive; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cell Communication and Signaling; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Proliferation; Complex; Congestive Heart Failure; Culture Media; Cytofluorometry, Flow; Development; Development and Research; Embryo; Embryonal Carcinoma Cell; Embryonic; Environment; Exhibits; FRP-4 protein, human; Family; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frizzled-Related Protein; GFAC; Gene Expression; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heart; Heart Decompensation; Heart Diseases; Heart Failure, Congestive; Heart myocyte; Human, Adult; Hypoxia; Hypoxic; In Vitro; Infarction; Injection of therapeutic agent; Injections; Injury; Interruption; Intracellular Communication and Signaling; Investigators; Laboratories; Lead; Lentivirinae; Lentivirus; Magnetism; Mammals, Mice; Mast Cell Growth Factor Receptor; Mediating; Methods and Techniques; Methods, Other; Mice; Micro RNA; MicroRNAs; Microfluorometry, Flow; Mitotic; Molecular; Molecular Interaction; Mother Cells; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Muscle, Involuntary; Muscle, Smooth; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardium; Myocytes; Myocytes, Cardiac; Natural regeneration; Organ; Oxygen Deficiency; Pb element; Physicians; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Progenitor Cells; Proto-Oncogene Protein c-kit; Quelling; R & D; R&D; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Recombinants; Regeneration; Research Personnel; Researchers; Role; SCF Receptor; SFRP4; SFRP4 protein, human; Scientist; Secreted Frizzled-Related Protein 4; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth muscle (tissue); Stem Cell Factor Receptor; Stem cells; Structural Protein; Study models; Subfamily lentivirinae; System; System, LOINC Axis 4; Techniques; Testing; Tissues; Training; University Medical Centers; Ursidae; Ursidae Family; Ventricular Dysfunction; Ventricular Function; Virus-Lenti; Work; adult human (21+); autocrine; base; biological signal transduction; c kit; c-kit Protein; c-kit Receptor; cardiac infarct; cardiac muscle; cardiomyocyte; coronary attack; coronary infarct; coronary infarction; cultured cell line; design; designing; flow cytophotometry; frpHE; frpHE protein, human; growth media; heart attack; heart disorder; heart infarct; heart infarction; heart muscle; heavy metal Pb; heavy metal lead; human SFRP4 protein; in vivo; infarct; kit Proto-Oncogene Protein; knock-down; mRNA Expression; magnetic; miRNA; myogenesis; novel; overexpression; p145(c-kit); p145c-kit; paracrine; prevent; preventing; progenitor; regenerate; regenerative; regenerative therapy; research and development; secreted frizzled-related protein 4, human; self-renewal; social role; transcription factor; vector",Role of SFRP2 in cardiac regeneration,,88317,NSS,,,5,249000,
7795159,R00,HL,5,,02/01/2010,01/31/2011,,5R00HL088372-03,,NHLBI:251829;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"PAI, JENNIFER K;",8675631;,5R00HL088372,04/01/2009,01/31/2012,"Active Follow-up; Age; Alcohol Drinking; Alcohol consumption; Alcohols; Apoplexy; Archives; Arginine; Arginine, L-Isomer; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BMI percentile; BMI z-score; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biochemical; Biological; Blood Plasma; Blood Pressure, High; Blood Sample; Blood specimen; Body Tissues; Body mass index; Cachectin Receptors; Cardiac Failure Congestive; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemical Class, Alcohol; Cohort Studies; Concurrent Studies; Congestive Heart Failure; Coronary Disease; Coronary heart disease; Coxa; Data; Diabetes Mellitus; Dietary Factors; Differentiation Factor, B-Cell; Disease; Disorder; Dysfunction; Dyslipidemias; EC 1.14.13.39; EDRF Synthase; Endothelium-Derived Growth Factor Synthase; Enzymes; EtOH drinking; Event; Functional disorder; Future; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Goals; Guanylyl Cyclase-Activating Factor Synthase; HPGF; Health; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Heart Decompensation; Heart Failure, Congestive; Hepatocyte-Stimulating Factor; Hip; Hip region structure; Hybridoma Growth Factor; Hypertension; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Inflammatory; Insulin Resistance; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intermediary Metabolism; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Life Style; Lifestyle; Lifestyle Factors, Unspecified; Link; Lipids; METBL; MGI-2; Maps; Measures; Metabolic Processes; Metabolism; Myeloid Differentiation-Inducing Protein; Myocardial Infarct; Myocardial Infarction; N(5)-((dimethylamino)iminomethyl)-L-ornithine; N(G),N(G)-dimethylarginine; N(G)-dimethylarginine; N(G1),N(G1)-dimethylarginine; N,N-dimethylarginine; NADPH-Diaphorase; NO Synthase; Nested Case-Control Study; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Nurses; Organ System, Cardiovascular; Oxidative Stress; Pathway interactions; Pb element; Peripheral arterial disease; Personnel, Nursing; Physiopathology; Plasma; Plasmacytoma Growth Factor; Polymorphism (Genetics); Polymorphism, Genetic; Predictive Value; Prevention; Process; Proteins; Questionnaires; Quetelet index; Research Specimen; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; Serum, Plasma; Smoking; Specimen; Stress; Stroke; Study, Nested Case-Control; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; Tissues; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Variant; Variation; Variation (Genetics); Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Woman; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic variant; asymmetric dimethylarginine; atherogenesis; atheromatosis; atherosclerotic vascular disease; brain attack; cardiac infarct; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; cerebral vascular accident; circulatory system; coronary attack; coronary disorder; coronary infarct; coronary infarction; diabetes; dimethyl-L-arginine; dimethylarginine; disease/disorder; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; follow-up; gene product; guanidino-N,N-dimethylarginine; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; improved; inflammatory marker; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insulin resistant; insulin sensitivity; interferon beta 2; lifestyle factors; men; men's; novel; novel therapeutic intervention; pathophysiology; pathway; polymorphism; premature; prevent; preventing; prospective; stroke","Asymmetric Dimethylarginine (ADMA), Genetic Variation, and Cardiovascular Disease",,88372,NSS,,,3,251829,
7769906,R00,HL,5,,02/01/2010,01/31/2011,PA-06-133,5R00HL088528-04,,NHLBI:247703;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,PATHOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"TEMEL, RYAN EUGENE;",2190079;,5R00HL088528,02/15/2009,01/31/2012,"ACAT; ACAT enzyme; Acyl-CoA-Cholesterol Acyltransferase; Acyl-CoA[{..}]cholesterol O-acyltransferase; Address; Adipose tissue; Affect; Agonist; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Apo-A; ApoA; Apolipoproteins; Apolipoproteins A; Blood Plasma; Cardiac Diseases; Cardiac Disorders; Catabolism; Cause of Death; Cercopithecus pygerythrus; Cessation of life; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Acyltransferase; Cholesterol Ester Lysolecithin Acyltransferase; Cholesterol Ester Transfer Proteins; Cholesterol Esterifying Enzyme; Cholesteryl Ester Transfer Protein; Choline Glycerophospholipids; Choline Phosphoglycerides; Coronary Disease; Coronary heart disease; DAG lipase; Data; Death; Development; Diacylglycerol Lipase; Diglyceride Lipase; Drugs; EC 2; Engineering; Engineerings; Fatty Tissue; Gastrointestinal Tract, Small Intestine; Gene Expression; Gene Expression Inhibitor; Genes; Green Monkey; HDL; HDL Cholesterol; Heart Diseases; Heavy Lipoproteins; Heparin-Clearing Factor; Hepatic; High Density Lipoprotein Cholesterol; High Density Lipoproteins; High density lipoprotein; Human Cell Line; Human Figure; Human body; Intermediary Metabolism; Intestinal; Intestines; Intestines, Small; LCAT; LDL Cholesterol; LDL Cholesterol Lipoproteins; LPL; Lecithin; Lecithin Acyltransferase; Lecithin Cholesterol Acyltransferase; Lipase; Lipemia-Clearing Factor; Lipoproteins, HDL; Lipoproteins, HDL Cholesterol; Liver; Low Density Lipoprotein Cholesterol; METBL; Mammals, Mice; Mediating; Medication; Mentors; Messenger RNA; Metabolic; Metabolic Processes; Metabolism; Mice; Monkey, African Green; Monkeys; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle; Muscle Tissue; Oligonucleotides, Antisense; Organ; PPAR delta; PPARD protein; PPARdelta; Peroxisome Proliferator-Activated Receptor delta; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phenotype; Phosophatidylcholine-Sterol Acyltransferase; Phosphatidyl Transfer Protein; Phosphatidylcholine-Sterol O-Acyltransferase; Phosphatidylcholines; Phospholipid Transfer Proteins; Plasma; Post-Heparin Lipase; Postheparin Lipase; Postheparin Lipoprotein Lipase; Production; Proteins; RNA, Messenger; Research; Reticuloendothelial System, Serum, Plasma; Risk Factors; Role; Sampling; Serum, Plasma; Site; Small Intestines; Specificity; Sterol O-Acyltransferase; Testing; Therapeutic; Transferase; Triacylglycero-protein acylhydrolase; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triolean Hydrolase; United States; Woman; acyl-CoA cholesterol acyltransferase; adipose; alpha-Lipoprotein Cholesterol; alpha-Lipoproteins; base; beta-Lipoprotein Cholesterol; body system, hepatic; bowel; cardiac disease risk; cardiac disorder risk; cholesterol ester transport protein, CETP; cholesteryl ester exchange protein; clearing factor lipase; coronary disorder; drug/agent; gene product; heart disease risk; heart disorder; heart disorder risk; hepatic lipase; in vitro Assay; in vivo; insight; intervention development; lipid exchange protein; lipid transfer protein; lipoprotein lipase; mRNA; men; men's; non-human primate; nonhuman primate; organ system, hepatic; phosphatidylcholine sterol acyltransferase; phospholipid cholesterol acyltransferase; prevent; preventing; protein expression; small bowel; social role; therapy development; treatment development; triacylglycerol protein acylhydrolase; tributyrase; white adipose tissue; yellow adipose tissue",Mechanisms For PPARdelta Agonist-Induced Elevation of HDL in Non-Human Primates,"Scientific data indicates that increasing HDL cholesterol may decrease the risk of heart disease, the leading  cause of death for men and women in the United States. We propose to determine the mechanisms by  which a new class of drugs, known as PPAR delta agonists, increase HDL-cholesterol in monkeys. Because  of the high degree of similarity between the bodies of humans and monkeys, we feel confidant that these  studies will provide insights for the development of therapies that could increase HDL and prevent the deaths  of hundreds of thousands of people each year from heart disease.",88528,NSS,,,4,247703,
7775025,R00,HL,5,,02/01/2010,01/31/2011,PA-07-297,5R00HL089412-04,,NHLBI:248999;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLOTTESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"CONNELLY, JESSICA J;",3088592;,5R00HL089412,02/23/2009,01/31/2012,"2(1H)-Pyrimidinone, 4-amino-; 2-amino-4-mercaptobutyric acid; Acetylation; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; Architecture; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Award; Binding; Binding (Molecular Function); Blinded; Blood Cells; Butanoic acid, 4,4'-dithiobis(2-amino)-; Candidate Disease Gene; Candidate Gene; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cell Aging; Cell Culture Techniques; Cell Death, Programmed; Cell Senescence; Cells; Cellular Aging; Chromosome 1; Chromosomes, Human, Pair 1; Clinical; Complex; Computer Analysis; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cytosine; DISSEC; DNA; DNA Binding; DNA Binding Interaction; DNA Methylation; DNA Molecular Biology; Data; Data Set; Dataset; Deoxyribonucleic Acid; Development; Diathesis; Disease; Disease susceptibility; Disorder; Dissection; Doctor of Philosophy; Dysfunction; Endothelial Cells; Engineering / Architecture; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Foam Cells; Functional disorder; Future; Gene Down-Regulation; Gene Transcription; Genes; Genetic; Genetic Population Study; Genetic Transcription; Genetics, Human; Genome; Genomics; Genotype; Goals; Haplotypes; Hematopoietic; Histones; Homocysteine; Homocysteine, L-Isomer; Homocystine; Human; Human Genetics; Human, General; Hyperhomocysteinemia; Idiopathic Parkinson Disease; In Vitro; Individual; K-Awards; K-Series Research Career Programs; Lead; Leiomyocyte; Lewy Body Parkinson Disease; Lipids; Logistic Regressions; Lymphocytes, Null; MTHFR; MTHFR gene; Man (Taxonomy); Man, Modern; Maps; Mentors; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Methylation; Modeling; Modification; Molecular; Molecular Biology; Molecular Interaction; Monitor; Myocytes, Smooth Muscle; NIH; NRSA; National Institutes of Health; National Institutes of Health (U.S.); National Research Service Awards; Nucleotides; Null Cells; Null Lymphocytes; Organ System, Cardiovascular; PBMC; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Patients; Pattern; Pb element; Peripheral Blood Cell; Peripheral Blood Mononuclear Cell; Ph.D.; PhD; Phase; Physiopathology; Play; Polymorphism Analysis; Polymorphism Detection; Polymorphism, Single Base; Population; Postdoc; Postdoctoral Fellow; Predisposing Factor; Predisposition; Primary Parkinsonism; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Proliferating; Protein Methylation; RNA Expression; Regression Analyses; Regression Analysis; Regression Diagnostics; Regressions, Logistic; Regulatory Pathway; Research; Research Associate; Research Career Program; Research Career Programs, K-Series; Resolution; Risk Factors; Role; SNP; SNP Map; SNPs; Scanning; Senescence, Cellular; Senescence, Replicative; Series; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism Map; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Statistical Regression; Streaks, Arterial Fatty; Susceptibility; System; System, LOINC Axis 4; Techniques; Testing; Training; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Translating; Translatings; United States National Institutes of Health; Universities; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Vascular, Heart; acute coronary syndrome; assault; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; base; bisulfite; cardiovascular disorder; career; case control; cell age; cell type; circulatory system; computational analysis; density; design; designing; disease/disorder; disease/disorder proneness/risk; early onset; epigenomics; experiment; experimental research; experimental study; gene repression; genome-wide linkage; heavy metal Pb; heavy metal lead; hydrogen sulfite; hydrosulfite; in vivo; language translation; liability to disease; novel; pathophysiology; pathway; post-doc; post-doctoral; programs; research study; response; social role; transcription factor; vulnerable plaque",Molecular Dissection of Cardiovascular Disease: From Genes to Models to Function,,89412,NSS,,,4,248999,
7743584,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA006902-23,,NIAAA:258684;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,SAN DIEGO,UNITED STATES,PSYCHOLOGY,53,073371346,US,CA,92182,SAN DIEGO STATE UNIVERSITY,"RILEY, EDWARD P;",1882196;,5R01AA006902,09/30/1988,11/30/2010,"0-11 years old; 1,3-Dimethyl-5-aminoadamantane; 1-Amino-3,5-dimethyladamantane; Absolute ethanol; Acute; Adverse effects; Affect; Alcohol withdrawal syndrome; Alcohol, Ethyl; Alcohols; Animal Model; Animal Models and Related Studies; Appearance; Behavioral; Behavioral Model; Biological Models; Blood Alcohol Content; Blood alcohol level measurement; Brain; Brain region; Care Givers; Caregivers; Central Nervous System; Chemical Class, Alcohol; Child; Child Youth; Children (0-21); Chronic; Common Rat Strains; Data; Development; Dose; ETOH; Encephalon; Encephalons; Ethanol; Face; Fetal Alcohol Exposure; Fetal Alcohol Syndrome; Fetal ETOH Exposure; Fetal Ethanol Exposure; Fetal alcohol effects; Generalized Growth; Gestation; Goltz-Gorlin syndrome; Grain Alcohol; Growth; Human; Human, Child; Human, General; In Utero Alcohol Exposure; In Utero ETOH Exposure; In Utero Ethanol Exposure; Last Trimester; Learning; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Medical; Memantin; Memantine; Methylcarbinol; Model System; Modeling; Models, Biologic; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; Neonatal Alcohol Exposure; Neonatal ETOH Exposure; Neonatal Ethanol Exposure; Nervous System, Brain; Nervous System, CNS; Neuraxis; Outcome; Play; Pregnancy; Pregnancy Trimester, Third; Prenatal Alcohol Exposure; Prenatal ETOH Exposure; Prenatal Ethanol Exposure; Property; Property, LOINC Axis 2; Publishing; Rat; Rattus; Receptors, N-Methylaspartate; Research; Role; Series; Severities; Testing; Third Pregnancy Trimester; Time; Tissue Growth; Treatment Side Effects; Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl-; Trimester, Third; Withdrawal; Work; alcohol abuse therapy; alcohol abuse treatment; alcohol effect; alcohol exposed; alcohol exposure; alcohol treatment; alcohol withdrawal; alcohol-exposed pregnancy; alcoholic embryopathy; alcoholism treatment; base; blood alcohol concentration; blood alcohol level; children; effective therapy; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol effect; ethanol exposed; ethanol exposure; ethanol withdrawal; excitotoxicity; exposed to alcohol; exposed to alcohol prenatally; exposure to alcohol; facial; fetal alcohol syndrome (FAS); gestation ETOH exposure; gestation alcohol exposure; gestation ethanol exposure; model organism; neonatal exposure; neuropathology; novel; ontogeny; perinatal ETOH exposure; perinatal alcohol exposure; perinatal ethanol exposure; pregnancy ETOH exposure; pregnancy alcohol exposure; pregnancy ethanol exposure; prenatal alcohol effect; prenatally alcohol exposed; prenatally exposed to alcohol; prevent; preventing; response; side effect; social role; standard of care; therapy adverse effect; treatment adverse effect; withdrawal from alcohol; youngster",Behavioral Effects of Neonatal Alcohol Exposure,,6902,NAL,Neurotoxicology and Alcohol Study Section,,23,258684,
7750600,R01,AA,5,,01/01/2010,12/31/2010,,5R01AA007850-20,,NIAAA:506987;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PROVIDENCE,UNITED STATES,MISCELLANEOUS,01,001785542,US,RI,02912,BROWN UNIVERSITY,"MONTI, PETER M.;",1905830;,5R01AA007850,08/01/1988,12/31/2010,"2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; AOD use; Abstinence; Adverse effects; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholic; Alcoholism; Alcohols; Attenuated; Behavioral Mechanisms; BlackBerry Device; Blueberry Device; Boozer; Chemical Class, Alcohol; Clinical; Clinical Trials; Clinical Trials, Unspecified; Computers, Palm-Top; Conduct Clinical Trials; Cues; D(2C) Dopamine Receptor Gene; D(4) Dopamine Receptor Gene; D4DR Gene; DRD4; DRD4 gene; Dependent drinker; Dopamine; Dopamine Receptor D4 Gene; Dose; Drug Therapy; Drug usage; Drugs; Environment; EtOH drinking; Ethanol dependence; Frequencies (time pattern); Frequency; Genetic; Genetic Polymorphism; Human; Human, General; Hydroxytyramine; Individual; Individual Differences; Intervention; Intervention Strategies; Laboratories; Laboratory Study; Man (Taxonomy); Man, Modern; Measures; Mechanisms of Behavior and Behavior Change; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Minisatellite Repeats; Minisatellites; PBO; PDA Computer; Palm Pilot; Palm-Top Computers; Palm-top; Palm-top computer; Palmtop; Palmtop Computers; Palmtop computer; Participant; Patient Self-Report; Personal Digital Assistant; Personal Digital Assistant Computer; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Placebo Control; Placebos; Pocket PCs; Pocket Personal Computer; Polymorphism (Genetics); Polymorphism, Genetic; Probability; Programs (PT); Programs [Publication Type]; Randomized; Randomized Clinical Trials; Receptor Gene; Reporting; Research; Sedation procedure; Self-Report; Sham Treatment; Simple Repetitive Sequence; Time; Titrations; Translating; Translatings; Transmission; Treatment Cost; Treatment Side Effects; Trials, Randomized Clinical; VNTR; VNTR Loci; VNTR Region; VNTR Sequences; Variable Number of Tandem Repeats; Variable Tandem Repeats; Woman; Work; alcohol addiction; alcohol addiction therapy; alcohol cue; alcohol dependence therapy; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism therapy; association test; attenuation; base; biobehavior; biobehavioral; clinical investigation; cost effectiveness; craving; cue reactivity; design; designing; drinking; drinking behavior; drug use; drug/agent; ethanol addiction; ethanol consumption; ethanol cue; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; experience; genetic association; improved; interventional strategy; language translation; men; men's; polymorphism; preclinical study; problem drinker; programs; randomisation; randomization; randomly assigned; response; sedation; sham therapy; side effect; substance use; therapy adverse effect; topiramate; transmission process; treatment adverse effect; treatment response; week trial",Biobehavioral mechanisms of topiramate and drinking,,7850,AA,"Biochemistry, Physiology and Medicine Subcommittee",,20,506987,
7761301,R01,AA,5,,02/01/2010,01/31/2011,,5R01AA010435-13,,NIAAA:280665;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"THIELE, GEOFFREY MILTON;",1974759;,5R01AA010435,01/01/1995,01/31/2012,"APC; ATGN; Acetaldehyde; Address; Adhesion Molecule; Alcoholic Hepatitis; Alcoholic Liver Diseases; Alcohols; Aldehydes; Antibodies; Antigen Presentation Pathway; Antigen Processing and Presentation; Antigen-Presenting Cells; Antigens; Autoregulation; Binding; Binding (Molecular Function); Biological; Biological Function; Biological Process; Blood Circulation; Bloodstream; Body Tissues; CCL2; CCL2 gene; CD106; CD106 Antigens; CD31 Antigens; CD54 (ICAM 1); CD54 Antigens; CD62P Antigens; CHO Cells; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Chemical Class, Alcohol; Chemicals; Chinese Hamster Ovary Cell; Chronic; Circulation; Cirrhosis; Cold-Insoluble Globulins; Common Rat Strains; Consumption; Cytokines, Chemotactic; Data; Development; ECM; EndoCAM; Endothelial Cells; Ethanal; Ethanol-induced hepatitis; Extracellular Matrix; FN1; FNZ; Family; Fibronectin 1; Fibronectins; Fibrosis; Formaldehyde; Formic Aldehyde; GDCF-2; GDCF-2 HC11; GMP-140; GPIIA'; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); HC11; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatitis, Alcoholic; Hepatocyte; Homeostasis; Homologous Chemotactic Cytokines; Host Defense; ICAM-1; INCAM-110; Immune response; Immunologic Accessory Cells; Immunologic Techniques; Immunological Technics; Immunological Techniques; In Vitro; Inducible Cell Adhesion Molecule 110; Infiltration; Inflammatory; Inflammatory Response; Injury; Intercellular adhesion molecule 1; Intercrines; Intracellular Communication and Signaling; Investigation; Investigators; LECAM-3; LETS Proteins; Laboratories; Large External Transformation-Sensitive Protein; Ligand Binding; Ligands; Liver; Liver Cells; Liver Fibrosis; Liver diseases; MCAF; MCP-1; MCP1; MGC9434; Malonaldehyde; Malondialdehyde; Malonylaldehyde; Malonyldialdehyde; Mammals, Rats; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methanal; Methyl Aldehyde; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Oxomethane; P-Selectin; PECAM-1; PECAM1; Physiological Homeostasis; Platelet Endothelial Cell Adhesion Molecule; Platelet Endothelial Cell Adhesion Molecule-1; Platelet alpha-Granule Membrane Protein; Play; Population; Programs (PT); Programs [Publication Type]; Propanedial; Protein Binding; Proteins; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Receptor Protein; Reporting; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Role; SCYA2; SIS cytokines; SMC-CF; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Staging; Technics, Immunologic; Tissues; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; accessory cell; acetylated LDL receptor; adduct; alcohol exposed; alcohol exposure; alcohol induced hepatic injury; alcohol induced liver disorder; alcohol induced liver injury; alcohol-induced hepatic dysfunction; alcohol-induced liver disease; alcohol-induced liver dysfunction; alcohol-mediated liver dysfunction; alcohol-mediated liver injury; alpha 2-Surface Binding Glycoprotein; biological signal transduction; body system, hepatic; cell adhesion protein; chemoattractant cytokine; chemokine; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; computerized data processing; cytokine; data processing; ethanol exposed; ethanol exposure; ethanol induced hepatic injury; ethanol induced liver disorder; ethanol induced liver injury; ethanol-induced hepatic dysfunction; ethanol-induced liver disease; ethanol-induced liver dysfunction; ethanol-mediated liver dysfunction; ethanol-mediated liver injury; exposed to alcohol; exposure to alcohol; gene product; hepatic fibrosis; hepatopathy; host response; immunogen; immunoresponse; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; liver disorder; liver function; organ system, hepatic; programs; receptor; receptor binding; receptor, acetyl-LDL; response; scavenger receptor; signal processing; social role; stellate cell",Alcohol and Liver Endothelial Cells in Immune Responses,,10435,HBPP,Hepatobiliary Pathophysiology Study Section,,13,280665,
7760976,R01,AA,5,,02/01/2010,01/31/2011,,5R01AA010615-11,,NIAAA:241684;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PHILADELPHIA,UNITED STATES,PATHOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"COVARRUBIAS, MANUEL L;",1866633;,5R01AA010615,01/01/1997,01/31/2012,"3-D structure; 3-dimensional structure; 3D structure; Absolute ethanol; Acute; Address; Alanine; Alanine, L-Isomer; Alcohol Intoxication; Alcohol dependence; Alcohol, Ethyl; Alcoholic Intoxication; Alcohols; Amino Acid Substitution; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, General; Architecture; Attention; Binding; Binding (Molecular Function); Binding Sites; Biotechnology, Genetic Engineering; Brain; C-terminal; Chemical Class, Alcohol; Chemosensitization; Chemosensitization/Potentiation; Combining Site; Coupling; Development; Drosophila; Drosophila genus; Drugs; Drunkenness; Drunkennesses; ETOH; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Engineering; Engineering / Architecture; Engineerings; EtOH intoxication; Ethanol; Ethanol dependence; Exhibits; Fruit Fly, Drosophila; Funding; General anesthetic drugs; Genetic Engineering; Genetics-Mutagenesis; Goals; Grain Alcohol; Hydrogen Bonding; Investigators; Ion Channel; Ion Channel Protein; Ion Channels, Potassium; Ionic Channels; K channel; Kinetic; Kinetics; L-Alanine; Laboratories; Length; Light; Lipid Bilayers; Maps; Medication; Membrane Channels; Methods; Methylcarbinol; Modeling; Molecular; Molecular Biology, Genetic Engineering; Molecular Biology, Mutagenesis; Molecular Interaction; Movement; Mutagenesis; NIAAA; National Institute on Alcohol Abuse and Alcoholism; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Organism; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Physiologic; Physiological; Position; Positioning Attribute; Potassium Channel; Potentiation; Probability; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Reactive Site; Recombinant DNA Technology; Research Personnel; Researchers; Resistance; Role; Scanning; Series; Site; Solutions; Structure; Study Subject; System; System, LOINC Axis 4; Tail; Testing; Therapeutic; Transplantation; Voltage-Gated K+ Channels; Voltage-Gated Potassium Channel; Work; alcohol addiction; alcohol dependency; alcohol effect; alcohol sensitivity; alcohol-dependent; base; body movement; drug/agent; ethanol addiction; ethanol dependency; ethanol effect; ethanol intoxication; ethanol sensitivity; ethanol-dependent; fruit fly; gene product; insight; interest; lipid bilayer membrane; living system; member; mutant; neuronal; patch clamp; programs; protein purification; protein structure; reconstitute; reconstitution; resistant; response; sensitivity to alcohol; sensitivity to ethanol; social role; structural biology; synthetic peptide; three dimensional structure; transplant",Mapping the alcohol site of a neuronal potassium channel,,10615,NAL,Neurotoxicology and Alcohol Study Section,,11,241684,
7741744,R01,AA,5,,12/01/2009,11/30/2010,PA-02-064,5R01AA011157-11,,NIAAA:320822;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,TAMPA,UNITED STATES,,11,139301956,US,FL,336129497,H. LEE MOFFITT CANCER CTR & RES INST,"DROBES, DAVID J;",1863734;,5R01AA011157,02/01/1998,11/30/2010,"Acute; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcoholic; Alcoholic beverage heavy drinker; Alcohols; Associative Learning; Behavioral; Behavioral Model; Boozer; Cessation of smoking; Chemical Class, Alcohol; Cigarette; Comorbidity; Conditioning, Classical; Conditionings, Classical; Consumption; Cues; Data; Dependent drinker; Dose; Drugs; ETOH level; Environment; EtOH drinking; Exhibits; Exposure to; General Population; General Public; Goals; Heavy Drinker; Human; Human, General; Individual; Individual Differences; Intake; Laboratories; Lead; Man (Taxonomy); Man, Modern; Medication; Methods; Modeling; Models, Statistical; Nicotine; Non-smoker; Pattern; Pavlovian conditioning; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Placebo Control; Probabilistic Models; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Reaction; Relapse; Reporting; Research; Risk; Self Administration; Smoke; Smoker; Smoking; Statistical Models; Tobacco; Tobacco Consumption; Tobacco use; Work; addiction; alcohol craving; alcohol cue; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol level; alcohol measurement; alcohol problem; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; cease smoking; classical conditioning; conditioning; craving; cue reactivity; design; designing; drinking; drug/agent; ethanol abuse; ethanol consumption; ethanol craving; ethanol cue; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol measurement; ethanol product use; ethanol use; ethyl alcohol measurements; etoh use; exposed to alcohol; exposure to alcohol; hazardous alcohol use; heavy metal Pb; heavy metal lead; non-alcoholic; non-smoking; nonalcoholic; nonsmoker; problem drinker; problem drinking; psycho-physiological; smoking cessation; sober; sobriety",Drug/Cue Interactions in Alcohol-Tobacco Comorbidity,,11157,ZRG1,Special Emphasis Panel,,11,320822,
7741745,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA011566-11,,NIAAA:396107;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,COLUMBIA,UNITED STATES,PSYCHOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"KELLY, SANDRA J.;",1870087;,5R01AA011566,09/25/1997,11/30/2010,"0-11 years old; 21+ years old; Absolute ethanol; Address; Adolescent; Adolescent Youth; Adult; Agonist; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Animal Model; Animal Models and Related Studies; Animals; Area; Auditory; Authorization; Authorization documentation; Autoradiography; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Mechanisms; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Binding; Binding (Molecular Function); Biological; Brain; CTOP; Cell Line; Cell Lines, Strains; CellLine; Central Nervous System; Chemical Class, Alcohol; Child; Child Youth; Children (0-21); Cities; Common Rat Strains; Complex; Conditioning Therapy; Congenital Anomalies, Nervous System; Congenital neurologic anomalies; Control Animal; Cues; Cys-Tyr; D-enkephalin; Detection; Development; Disclosure; Disease; Disorder; Dose; Dysmorphology; ETOH; Encephalon; Encephalons; Environment; Environmental Factor; Environmental Risk Factor; Esthesia; EtOH drinking; Ethanol; FASD; FLR; FOS gene; Face; Failure (biologic function); Female; Fetal Alcohol Spectrum Disorder; G0S7; Gene Expression; Generalized Growth; Gestation; Grain Alcohol; Growth; Human; Human Resources; Human, Adult; Human, Child; Human, General; Individual; Information Disclosure; Instruction; Investigators; Laboratories; Last Name; Laws; Life; Life Style Modification; Link; Mammals, Rats; Man (Taxonomy); Man, Modern; Manpower; Maternal Behavior; Mechanisms of Behavior and Behavior Change; Mediating; Mental Health; Mental Hygiene; Methods; Methods and Techniques; Methods, Other; Methylcarbinol; Microinjections; Modeling; Molecular Interaction; Mothers; N-L-cysteinyl-L-tyrosine; Names; Nature; Neonatal; Nervous; Nervous System Abnormalities; Nervous System Anomalies; Nervous System Congenital Abnormalities; Nervous System Congenital Malformations; Nervous System Malformations; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurobiology; Opioid; Performance; Permission; Play; Pregnancy; Principal Investigator; Printing; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Protooncogene FOS; Psychological Health; Psychology; Public Health; R01 Mechanism; R01 Program; RPG; Radioautography; Rat; Rattus; Reaction; Receptors, Opioid, mu; Receptors, mu; Registries; Reports, Progress; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Role; Schools, Medical; Sensation; Sensory; Sensory Process; Site; Social Behavior; Social Environment; Social Interaction; Societies; South Carolina; Structure; Symptoms; System; System, LOINC Axis 4; Techniques; Testing; Time; Tissue Growth; Translating; Translatings; Universities; Visual; Woman; Work; adult human (21+); alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; behavior intervention; behavioral intervention; c fos; c-fos Gene; c-fos Proto-Oncogenes; children; congenital nervous system disorder; cultured cell line; cysteinyltyrosine; disease/disorder; environmental risk; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; facial; failure; hESC; human ES cell; human ESC; human embryonic stem cell; immunocytochemistry; immunoreactivity; juvenile; juvenile human; language translation; medical schools; model organism; neural; neural mechanism; neurobiological; neurobiological mechanism; neuromechanism; ontogeny; personnel; postnatal; prenatal; programs; public health medicine (field); pup; relating to nervous system; research study; response; social; social climate; social context; social role; sociobehavior; sociobehavioral; socioenvironment; somatosensory; unborn; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; youngster","Alcohol exposure, social behavior and development",,11566,ZRG1,Special Emphasis Panel,,11,396107,
7746442,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA012070-10,,NIAAA:252628;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,MANHATTAN,UNITED STATES,ANATOMY/CELL BIOLOGY,02,929773554,US,KS,665061103,KANSAS STATE UNIVERSITY,"KUMARI, MEENA ;",2284689;,5R01AA012070,02/01/1999,11/30/2010,"2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3; Absolute ethanol; Acids; Actinomycin A IV; Actinomycin C1; Actinomycin D; Actinomycin I1; Actinomycin IV; Actinomycin X 1; Actinomycin-[thr-val-pro-sar-meval]; Alcohol dependence; Alcohol, Ethyl; Alcohols; Antibodies; Assay; Bioassay; Biologic Assays; Biological Assay; Blood reticulocyte; Blotting, Western; Brain; Cell Culture Techniques; Cell Nucleus; Cells; Chemical Class, Alcohol; Chronic; Code; Coding System; Complementary DNA; Computer Programs; Computer software; Cosmegen; Cytosol; DACT; DNA, Complementary; Dactinomycin; Dactinomycine; Data; Development; Diffusely basophilic erythrocyte; Disease; Disorder; ETOH; Encephalon; Encephalons; Ethanol; Ethanol dependence; Exons; Gene Probes, RNA; Gene Products, RNA; Gene Transcription; Genes; Genes, Reporter; Genetic Transcription; Genetics, in situ Hybridization; Goals; Grain Alcohol; Grant; Half-Life; Half-Lifes; In Situ; In Situ Hybridization; In Vitro; Incubated; Investigators; L-Methionine; Lead; Length; Lyovac cosmegen; Mammals, Rabbits; Marrow reticulocyte; Mediating; Memory; Meractinomycin; Messenger RNA; Methionine; Methionine, L-Isomer; Methylcarbinol; Molecular; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NR1; NR1 gene; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Transmission; Neurons; Nucleases, RNA; Nucleus; Oryctolagus cuniculus; Pb element; Peptide Biosynthesis, Ribosomal; Pharmacology; Physiology; Plasmids; Play; Polychromatophilic Erythrocyte; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Quelling; RNA; RNA Expression; RNA Interference; RNA Probes; RNA Silencing; RNA Silencings; RNA Splicing; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Protein Interaction; RNAi; RNase; Rabbit, Domestic; Rabbits; Receptor Protein; Receptors, N-Methylaspartate; Regulation; Reporter Genes; Research Personnel; Researchers; Reticulocytes; Ribonuclease Family Protein; Ribonucleases; Ribonucleic Acid; Role; Scintillation Counting; Sequence-Specific Posttranscriptional Gene Silencing; Site; Software; Splicing; Stability, mRNA; System; System, LOINC Axis 4; Testing; Transcription; Transcription, Genetic; Transfection; Translations; UTRs; Untranslated Regions; Variant; Variation; Western Blotting; Western Blottings; Western Immunoblotting; alcohol addiction; alcohol addiction therapy; alcohol dependence therapy; alcohol dependency; alcohol effect; alcohol exposed; alcohol exposure; alcohol-dependent; alcoholism therapy; cDNA; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; computer program/software; design; designing; disease/disorder; ethanol addiction; ethanol dependency; ethanol effect; ethanol exposed; ethanol exposure; ethanol-dependent; exposed to alcohol; exposure to alcohol; fetal; gene product; heavy metal Pb; heavy metal lead; immunocytochemistry; in situ Hybridization Staining Method; in vivo; internal control; knock-down; mRNA; mRNA Stability; neuronal; neurotransmission; novel therapeutic intervention; polypeptide; programs; protein blotting; protein synthesis; receptor; social role; time interval; translation assay",Ethanol-induced NMDA R1 mRNA Stabilization,,12070,NAL,Neurotoxicology and Alcohol Study Section,,10,252628,
7714722,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA012153-09,,NIAAA:324101;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BIRMINGHAM,UNITED STATES,BIOCHEMISTRY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"KEDISHVILI, NATALIA Y;",1888377;,5R01AA012153,04/01/2000,11/30/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 21+ years old; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; ATRA; Adult; Alcoholic Liver Diseases; Aldehydes; All-Trans-Retinol; All-trans retinoic acid; Anabolism; Anti-Infective vitamin; Antixerophthalmic vitamin; Autoregulation; Axerophthal; Axerophthol; Axerophtholum; Back; Biosterol; Body Tissues; Cells; Cellular Retinol Binding Protein; Complement; Complement Proteins; Dehydrogenases; Development; Dorsum; Enzymes; Equilibrium; Fetal Alcohol Syndrome; Funding; Gene Expression; Genes; Goltz-Gorlin syndrome; Homeostasis; Human; Human, Adult; Human, General; Hydroxysteroids; In Vitro; Intermediary Metabolism; Knockout Mice; Lard-Factor; Life; Liver; METBL; Malignant Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Murine; Mus; NADPH specific short chain dehydrogenase; Null Mouse; Oleovitamin A; Ophthalamin; Ortholog; Orthologous Gene; Oxidoreductase; Physiological Homeostasis; Play; Production; Protein Family; Proteins; Reductases; Reporting; Retinaldehyde; Retinene; Retinoic Acid; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Retroviral Vector; Retrovirus Vector; Role; Skin; Sterols; System; System, LOINC Axis 4; Testing; Tissues; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Vitamin A Acid; Vitamin A Alcohol; Vitamin A Aldehyde; Vitamin A USP; adult human (21+); alcohol induced hepatic injury; alcohol induced liver disorder; alcohol induced liver injury; alcohol-induced hepatic dysfunction; alcohol-induced liver disease; alcohol-induced liver dysfunction; alcohol-mediated liver dysfunction; alcohol-mediated liver injury; alcoholic embryopathy; all-trans-Retinoic Acid; all-trans-Vitamin A acid; animal tissue; balance; balance function; base; biosynthesis; body system, hepatic; cancer cell; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol induced hepatic injury; ethanol induced liver disorder; ethanol induced liver injury; ethanol-induced hepatic dysfunction; ethanol-induced liver disease; ethanol-induced liver dysfunction; ethanol-mediated liver dysfunction; ethanol-mediated liver injury; experiment; experimental research; experimental study; fetal; fetal alcohol syndrome (FAS); gene product; human tissue; in vivo; mouse model; organ system, hepatic; oxidation; research study; retinal (bacteriorhodopsin); retinol; short chain reductase; short chain trans-2-enoyl-CoA reductase; short chain trans-2-enoyl-coenzyme A reductase; social role; trans-Retinoic Acid",Short-Chain Dehydrogenases in Retinol/Sterol Metabolism,,12153,INMP,Integrative Nutrition and Metabolic Processes Study Section,,9,324101,
7754121,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA012908-07,,NIAAA:372214;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"DE LA MONTE, SUZANNE M.;",1962772;,5R01AA012908,02/01/2003,12/31/2013,"1-Phosphatidylinositol 3-Kinase; 12-20 years old; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Absolute ethanol; Acetaldehyde; Acetylcholine; Address; Adolescence; Adolescent; Adolescent Youth; Adverse effects; Agonist; Alcohol, Ethyl; Asses; Binding; Binding (Molecular Function); Biochemical; Brain; Cell Communication and Signaling; Cell Signaling; Chemicals; Chronic; Common Rat Strains; DNA Adduct Formation; DNA Adduction; DNA Damage; DNA Injury; Data; Defect; Donkey; Dose; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ETOH; Effectiveness; Encephalon; Encephalons; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Equus asinus; Ethanal; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethanol; Experimental Designs; Exposure to; FASD; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal ETOH Exposure; Fetal Ethanol Exposure; Functional impairment; Gender Role; Genetic; Goals; Grain Alcohol; HEK3; Human; Human, General; INSR; IRS-1 protein; IRS1; IRTK enzyme; Impairment; In Utero Alcohol Exposure; In Utero ETOH Exposure; In Utero Ethanol Exposure; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Receptor Substrate 1; Insulin Resistance; Insulin-Dependent Tyrosine Protein Kinase; Intermediary Metabolism; Intracellular Communication and Signaling; Link; METBL; Mammals, Rats; Man (Taxonomy); Man, Modern; Mars; Mediating; Mental Retardation; Metabolic Processes; Metabolism; Methylcarbinol; Molecular; Molecular Interaction; Motor; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Injury; Neurons; Neurotoxins; Oxidative Stress; PI-3 Kinase; PI-3K; PI3-Kinase; PPAR; PTK; Perinatal Exposure; Peroxisome Proliferator-Activated Receptors; Phosphatases; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Planet Mars; Prenatal Alcohol Exposure; Prenatal ETOH Exposure; Prenatal Ethanol Exposure; Production; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; PtdIns 3-Kinase; Rat; Rattus; Receptor Protein; Severities; Sex Roles; Signal Transduction; Signal Transduction Systems; Signaling; Therapeutic; Transmission; Treatment Side Effects; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; adolescence (12-20); alcohol effect; alcohol exposed; alcohol exposure; alcohol-exposed pregnancy; biological signal transduction; ethanol effect; ethanol exposed; ethanol exposure; experiment; experimental research; experimental study; exposed to alcohol; exposed to alcohol prenatally; exposure to alcohol; fetal exposure; functional disability; gestation ETOH exposure; gestation alcohol exposure; gestation ethanol exposure; hydroxyaryl protein kinase; in utero exposure; in vitro Model; in vivo; insulin receptor substrate 1 protein; insulin receptor tyrosine kinase; insulin resistant; insulin sensitizer; insulin sensitizing drugs; insulin signaling; insulin-induced receptor tyrosine kinase; intra-uterine environmental exposure; intrauterine environmental exposure; juvenile; juvenile human; mitochondrial dysfunction; neuron injury; neuronal; neuronal survival; neurotoxicant; pregnancy ETOH exposure; pregnancy alcohol exposure; pregnancy ethanol exposure; prenatally alcohol exposed; prenatally exposed to alcohol; prevent; preventing; public health relevance; pup; receptor; research study; side effect; synapse formation; synaptogenesis; teenage; therapeutic effectiveness; therapy adverse effect; transmission process; treatment adverse effect; tyrosyl protein kinase",EFFECTS OF ETHANOL ON INSULIN SIGNALING IN THE BRAIN," W  ae ikd ea  loo  pcrm iodrascae  ri  bomlte  o nui  eitne xdtv tes n ern. rlmnr aa ugs ht rntl loo xoue a as esset r rgesv ernl nuy n dlset ris n hrfr, e o rps o hrceie h ere o hc r-aa loo xoue ass oglsig des fet n ri ucin  u eod ol s vlae ramns ht agt h nelig ass f tao-eitd ri bomlte n ses hi fetvns n rvnig tutrl n ucinl maret n dlset ris olwn hoi rn loo xoue ",12908,NAL,Neurotoxicology and Alcohol Study Section,,7,372214,
7741747,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA012958-09,,NIAAA:269930;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BROOKLYN,UNITED STATES,PHYSIOLOGY,11,040796328,US,NY,11203,SUNY DOWNSTATE MEDICAL CENTER,"SMITH, SHERYL S;",1900730;,5R01AA012958,05/01/2000,11/30/2010,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Absolute ethanol; Acute; Affect; Affinity; Agonist; Alanine; Alanine, L-Isomer; Alcohol, Ethyl; Alcohols; Aminalon; Aminalone; Ammon Horn; Area; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Blood Alcohol Content; Blood alcohol level measurement; Brain; Brain region; Butanoic acid, 4-amino-; C-terminal; Cells; Cerebellar Ataxia; Cerebellar Incoordination; Cerebellum; Characteristics; Chemical Class, Alcohol; Chemosensitization; Chemosensitization/Potentiation; Chemotherapy-Hormones/Steroids; Chimera; Chimera organism; Combining Site; Cornu Ammonis; Data; Dentate Fascia; Dentate Gyrus; Dose; Drugs; ETOH; Encephalon; Encephalons; Endocrine Gland Secretion; Ethanol; Exposure to; Fascia Dentata; GABA; GABA Agonists; GABA Receptor Agonists; GABA(A) receptor delta; GABA-A Receptor; GABRD gene product, human; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Grain Alcohol; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Hormones; In Vitro; Intraventricular; Isoforms; Kinetic; Kinetics; L-Alanine; L-Leucine; L-Serine; L-Tryptophan; Leucine; Leucine, L-Isomer; Levotryptophan; Limbic System; Mammals, Mice; Mediating; Medication; Methylcarbinol; Mice; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Moods; Msec; Murine; Mus; Mutagenesis; Mutagenesis, Site-Directed; Mutate; Mutation; Nervous System, Brain; Outcome; Patch-Clamp Technics; Patch-Clamp Techniques; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiology; Point Mutation; Potentiation; Probability; Property; Property, LOINC Axis 2; Protein Isoforms; Pyramidal Cells; Reactive Site; Receptor Protein; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; Recombinants; Reporting; Role; Serine; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Slice; Specificity; Steroid Compound; Steroids; Structure of dentate gyrus; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic Hormone; Time; Tryptophan; Tube; Up-Regulation; Up-Regulation (Physiology); Upregulation; Withdrawal; alcohol effect; blood alcohol concentration; blood alcohol level; dentate gyrus; desensitization; drug/agent; ethanol effect; gamma-Aminobutyric Acid; gamma-Aminobutyric Acid Agonists; gamma-aminobutyric acid A receptor delta, human; genome mutation; granule cell; hippocampal; human gamma-aminobutyric acid A receptor delta; insight; knock-down; millisecond; mutant; novel; prevent; preventing; receptor; response; selective expression; selectively expressed; social role","Alcohol, GABA and hormones: Physiology of subunit change",,12958,NAL,Neurotoxicology and Alcohol Study Section,,9,269930,
7741748,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA013395-09,,NIAAA:291691;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BIRMINGHAM,UNITED STATES,PATHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"DARLEY-USMAR, VICTOR M;",1864202;,5R01AA013395,03/05/2002,11/30/2011,"AMP Kinase; ATP-AMP Phosphotransferase; ATP-AMP Transphosphorylase; Absolute ethanol; Adenylokinase; Alcohol Hepatotoxicity; Alcohol dependence; Alcohol, Ethyl; Alcoholic Hepatotoxicity; Alcoholism; Alcohols; Animal Feed; Antioxidants; Cells; Chemical Class, Alcohol; Chronic; Common Rat Strains; DNA, Mitochondrial; Data; Development; Diet; Drugs; Dysfunction; EC 1.14.13.39; EDRF Synthase; ETOH; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Ethanol; Ethanol dependence; Functional disorder; Funding; Grain Alcohol; Guanylyl Cyclase-Activating Factor Synthase; Hepatic; Hepatocyte Nitric Oxide Synthase; Hepatotoxic effect; Hepatotoxicity; Human; Human, General; Hypoxia; Hypoxic; INOS; In element; Indium; Inducible Nitric Oxide Synthase; Investigators; Isoforms; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Liver; Liver Toxicity; Macrophage Nitric Oxide Synthase; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Medication; Methylcarbinol; Mice; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Modeling; Modification; Mononitrogen Monoxide; Murine; Mus; Myokinase; N element; N2 element; NADPH-Diaphorase; NO Synthase; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Oxygen; Oxygen Deficiency; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteome; Proteomics; Public Health; Rat; Rattus; Research Personnel; Researchers; Respiration; Respiratory Chain; Role; Testing; Therapeutic Uses; Toxic effect; Toxic effect on liver cells; Toxicities; adenylate kinase; alcohol abuse therapy; alcohol abuse treatment; alcohol addiction; alcohol dependency; alcohol exposed; alcohol exposure; alcohol response; alcohol treatment; alcohol-dependent; alcoholism treatment; animal food; anti-oxidant; body system, hepatic; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; drug/agent; endothelial cell derived relaxing factor; ethanol addiction; ethanol dependency; ethanol exposed; ethanol exposure; ethanol response; ethanol-dependent; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; heavy metal Pb; heavy metal lead; hepatoxicity; human NOS2A protein; iNOS enzyme; inflammatory marker; inhibitor; inhibitor/antagonist; mitochondrial; mitochondrial dysfunction; mtDNA; new approaches; nitric oxide synthase, Type II; novel; novel approaches; novel strategies; novel strategy; organ system, hepatic; pathophysiology; prevent; preventing; programs; public health medicine (field); research study; respiratory mechanism; response; response to alcohol; response to ethanol; social role",Ethanol Hepatotoxicity and NO-Dependent Mitochondrial Dysfunction,,13395,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,9,291691,
7754097,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA013746-07,,NIAAA:719353;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHICAGO,UNITED STATES,PSYCHIATRY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"KING, ANDREA C;",1882163;,5R01AA013746,07/01/2002,12/31/2013,"Accidents; Active Follow-up; Acute; Adverse effects; Aeroseb-HC; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Award; Biological; Blood Alcohol Content; Blood alcohol level measurement; Cetacort; Chemical Class, Alcohol; Chronic; Chronotropism, Cardiac; Chronotropisms, Cardiac; Cognitive; Control Groups; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Country; Data; Dermacort; Early identification; Early treatment; Eldecort; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Exhibits; Eye Movements; Family Medical History; Family history of; Frequencies (time pattern); Frequency; Funding; Future; Goals; Health; Heart Rate; Heavy Drinker; Hydrocortisone; Hydrocortone; Hytone; Individual; Intervention; Intervention Strategies; Investigation; Knowledge; Laboratories; Life; Light; Maintenance; Maintenances; Measures; Models, Theoretic; Motor; Multivariate Analyses; Multivariate Analysis; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutracort; PBO; Pattern; Performance; Personality Traits; Persons; Phase; Photoradiation; Placebo Control; Placebos; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Prevention; Prevention education; Procedures; Proctocort; Productivity; Progress Reports; Race; Racial Group; Recruitment Activity; Relative; Relative (related person); Reports, Progress; Research; Rewards; Risk; Risk Factors; Role; SAMHSA; Safety; Salivary; Sample Size; Sedation procedure; Sham Treatment; Stocks, Racial; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Testing; Theoretical model; Therapeutic Hydrocortisone; Time; Treatment Side Effects; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Woman; adult youth; alcohol addiction; alcohol dependency; alcohol effect; alcohol ingestion; alcohol intake; alcohol intervention; alcohol misuse; alcohol product use; alcohol response; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; at-risk drinking; base; binge alcohol consumption; binge drinker; binge drinking; blood alcohol concentration; blood alcohol level; bout drinker; cohort; desensitization; drinking; drinking behavior; episodic drinker; episodic drinking; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol misuse; ethanol product use; ethanol response; ethanol use; ethanol use disorder; ethanol-dependent; etoh use; follow-up; hazardous drinking; high risk drinking; improved; interventional strategy; longitudinal design; men; men's; prospective; public education; public health relevance; recruit; response; response to alcohol; response to ethanol; risky drinking; sedation; sedative; sex; sham therapy; side effect; social; social role; therapy adverse effect; treatment adverse effect; young adult",Alcohol Stimulation and Sedation in Binge Drinkers," Narrative Chronic heavy or ""binge"" alcohol drinking remains a serious problem in this country and the consequences of this excessive use are widespread. This study will conduct long-term examination of response to alcohol in the laboratory and drinking patterns over time in a well-established cohort of young adult binge and light social drinkers. Equally important, the potential protective factors underlying low risk drinking will also be examined.",13746,ZAA1,Special Emphasis Panel,,7,719353,
7760032,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA013892-07,,NIAAA:586557;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SINHA, RAJITA ;",1974755;,5R01AA013892,01/20/2009,12/31/2013,"5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-; 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)-; 5,8,11,14-eicosatetraenoylethanolamide; ACTH; ACTH (1-39); Acute; Address; Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Affect; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Arousal; Behavioral; Biochemical; Biochemical Markers; Blood Pressure; Blood Pressure, Low; Boozer; Brain; C 1 Esterase; C1 Esterase; C1 s; C1s; Cannabinoids, Endogenous; Cessation of life; Cetacort; Chemical Class, Alcohol; Chronic; Chronotropism, Cardiac; Chronotropisms, Cardiac; Cognitive; Complement 1 Esterase; Complement 1s; Complement component C1s; Cort-Dome; Cortef; Cortenema; Corticotropin; Corticotropin (1-39); Cortisol; Cortispray; Cortril; Cues; Death; Dependent drinker; Dermacort; Development; Disease; Disorder; Distress; Eldecort; Emotions; Encephalon; Encephalons; Endocannabinoids; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Exposure to; Family Medical History; Family history of; Foxes; Funding; Gender; Guided imagery; Gustation; Heart Rate; Heavy Drinker; Heavy Drinking; Human; Human, General; Hydrocortisone; Hydrocortone; Hypotension; Hytone; Imagery; Imagery (Psychotherapy); Individual; Individual Differences; Inpatients; Intervention; Intervention Strategies; Laboratories; Length of Stay; Literature; Man (Taxonomy); Man, Modern; Markers, Biochemical; Measures; Mental disorders; Mental health disorders; Motivation; N arachidonoyl 2 hydroxyethylamide; N-(2-hydroxyethyl)arachidonamide; Nervous System, Brain; Nicotine; Number of Days in Hospital; Nutracort; Pathway interactions; Pattern; Physiologic; Physiological; Play; Predisposition; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Prevention; Procedures; Proctocort; Progress Reports; Psychiatric Disease; Psychiatric Disorder; Psychotherapeutic Imagery; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Race; Racial Group; Relapse; Reports, Progress; Rewards; Risk; Role; Sampling; Series; Severities; Stocks, Racial; Stress; Susceptibility; Symptoms; Taste; Taste Perception; Testing; Therapeutic Hydrocortisone; Unspecified Mental Disorder; Vascular Hypotensive Disorder; Visualization; addiction; alcohol addiction; alcohol craving; alcohol cue; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol relapse; alcohol response; alcohol seeking; alcohol seeking behavior; alcohol use; alcohol withdrawal; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; anandamide; anandamide (20.4,n-6); arachidonoyl ethanolamide; arachidonoylethanolamide; arachidonylethanolamide; behavior measurement; behavioral measure; behavioral measurement; binge alcohol consumption; binge drinker; binge drinking; biological adaptation to stress; bout drinker; craving; design; designing; disease/disorder; drink heavily; drinking; episodic drinker; episodic drinking; ethanol abuse; ethanol addiction; ethanol consumption; ethanol craving; ethanol cue; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol relapse; ethanol response; ethanol seeking; ethanol use; ethanol withdrawal; ethanol-dependent; ethanol-seeking behavior; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; hazardous alcohol use; heavy alcohol use; hospital days; hospital length of stay; hospital stay; interventional strategy; mental illness; neuroadaptation; pathway; problem drinker; problem drinking; psychological disorder; reaction; crisis; response; response to alcohol; response to ethanol; social role; stress response; stress; reaction; stressor; withdrawal from alcohol",Chronic Alcohol and Brain Stress Circuit Response," Relevance: Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. The proposed study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.",13892,ZRG1,Special Emphasis Panel,,7,586557,
7741750,R01,AA,5,,12/01/2009,11/30/2010,,5R01AA014886-06,,NIAAA:547578;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,ALBUQUERQUE,UNITED STATES,,01,098640696,US,NM,87106,THE MIND RESEARCH NETWORK,"HUTCHISON, KENT E;",1861770;,5R01AA014886,12/01/2005,11/30/2010,"2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Abstinence; Active Follow-up; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic; Alleles; Allelomorphs; Attenuated; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biological; Boozer; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; Conditioning Therapy; Cues; D(2C) Dopamine Receptor; D(2C) Dopamine Receptor Gene; D(4) Dopamine Receptor; D(4) Dopamine Receptor Gene; D4DR; D4DR Gene; DRD4; DRD4 Protein; DRD4 gene; DRD4 protein, human; Data; Dependence; Dependent drinker; Development; Dopamine; Dopamine Antagonists; Dopamine Receptor Antagonists; Dopamine Receptor D4; Dopamine Receptor D4 Gene; Dopaminergic Antagonists; Dose; Drug Therapy; Drugs; Du Pont Brand of Naltrexone Hydrochloride; Effectiveness; EtOH drinking; Ethanol dependence; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Markers; Genetic Polymorphism; Genetic Variation; Hydroxytyramine; Individual; Individual Differences; Intervention; Intervention Strategies; Investigators; Lamepro Brand of Naltrexone Hydrochloride; Life Style Modification; Maintenance; Maintenances; Mediating; Medication; Minisatellite Repeats; Minisatellites; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; NIAAA; Nalorex; Naltrexone; National Institute on Alcohol Abuse and Alcoholism; Nemexin; Orphan Brand of Naltrexone Hydrochloride; Outcome; PBO; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Placebo Control; Placebos; Polymorphism (Genetics); Polymorphism, Genetic; Process; Programs (PT); Programs [Publication Type]; ReVia; Receptor Protein; Research; Research Personnel; Researchers; Sampling; Schering-Plough Brand of Naltrexone Hydrochloride; Severities; Sham Treatment; Simple Repetitive Sequence; Testing; United Drug Brand of Naltrexone Hydrochloride; VNTR; VNTR Loci; VNTR Region; VNTR Sequences; Variable Number of Tandem Repeats; Variable Tandem Repeats; Variant; Variation; Variation (Genetics); alcohol addiction; alcohol craving; alcohol dependency; alcohol effect; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; allelic variant; base; behavior intervention; behavioral intervention; craving; dopamine D4 receptor; dopamine receptor D4 protein, human; drinking; drinking behavior; drug/agent; ethanol abuse; ethanol addiction; ethanol consumption; ethanol craving; ethanol dependency; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; follow up assessment; follow-up; genetic variant; hazardous alcohol use; human DRD4 protein; interventional strategy; olanzapine; polymorphism; problem drinker; problem drinking; programs; receptor; reduced alcohol use; response; sham therapy; week trial",A New Pharmacotherapy for Alcohol Dependence: Olanzapine,,14886,ZAA1,Special Emphasis Panel,,6,547578,
7759646,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA015923-02,,NIAAA:551097;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"CIRAULO, DOMENIC ANTHONY;",1873419;,5R01AA015923,01/10/2009,12/31/2013,"2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; Adoption; Advanced Development; Adverse effects; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Anxiety; Arm; Attention; Blood Plasma; Blood Serum; C-D-transferrin; Chemical Class, Alcohol; Chemical Structure; Chemicals; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Control Groups; Data; Depression; Development; Digit; Digit structure; Disturbance in cognition; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Therapy; Drugs; Effectiveness; Epilepsy; Epileptic Seizures; Epileptics; EtOH drinking; Ethanol dependence; FDA approved; Future; Goals; Health; Heavy Drinking; Human; Human, General; Impaired cognition; Impairment; Individual; Interdisciplinary Research; Interdisciplinary Study; Investigation; Levetiracetam; Literature; Man (Taxonomy); Man, Modern; Measures; Medication; Mental Depression; Mind; Modality; Moods; Multidisciplinary Collaboration; Multidisciplinary Research; New Agents; Outcome; Outcome Measure; PBO; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacologic Actions; Pharmacotherapy; Placebo Control; Placebos; Plasma; Pyrrolidines; QOL; Quality of life; Regulation; Relapse; Research Design; Reticuloendothelial System, Serum, Plasma; Safety; Sampling; Screening procedure; Seizure Disorder; Serum; Serum, Plasma; Sham Treatment; Sleep; Smoking; Study Type; Study, Interdisciplinary; Sulfonamides; Testing; Time; Toxic effect; Toxicities; Treatment Side Effects; Upper arm; Withdrawal Symptom; Word Association Tests; active control; active method; alcohol addiction; alcohol addiction therapy; alcohol craving; alcohol dependence therapy; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcohol use disorder; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism pharmacotherapy; alcoholism therapy; base; carbohydrate-deficient transferrin; clinical investigation; clinical practice; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; comparative; comparative efficacy; drink heavily; drinking; drug efficacy; drug/agent; epilepsia; epileptiform; epileptogenic; ethanol addiction; ethanol consumption; ethanol craving; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol use disorder; ethanol-dependent; etiracetam, S-isomer; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experiment; experimental research; experimental study; extreme drinking; glutamyltransferase; heavy alcohol use; improved; indexing; innovate; innovation; innovative; multi-site trial; neuron toxicity; neuronal toxicity; neurotoxicity; novel; pre-clinical; preclinical; primary outcome; public health relevance; pyrrolidine; research study; screening; screenings; sham therapy; side effect; study design; sugar; sulfamate; therapy adverse effect; topiramate; treatment adverse effect",Interdisciplinary Study of Two Novel Anticonvulants in Alcoholism, PROJECT NARRATIVE Currently approved medications for the treatment of alcoholism are associated with limited effectiveness and their adoption in clinical practice has been slow. The goal of the current study is to find more effective and safer medications for alcoholism by studying agents that differ in chemical structure and pharmacologic actions from those currently available.,15923,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,551097,
7750598,R01,AA,5,,01/01/2010,12/31/2010,PA-05-046,5R01AA016117-04,,NIAAA:438149;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,ANN ARBOR,UNITED STATES,PSYCHIATRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BROWER, KIRK J;",2455270;,5R01AA016117,01/20/2007,12/31/2011,"1-(aminomethyl)cyclohexaneacetic Acid; 21+ years old; AOD use; Abstinence; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Active Follow-up; Acute; Adult; Affect; Age; Alcohol dependence; Alcohol or Other Drugs use; Alcohol withdrawal syndrome; Alcoholic; Alcoholism; Apnea, Sleep; Biological; Boozer; Brain; Central Nervous System; Cessation of life; Characteristics; Chronic Disease; Chronic Illness; Circadian Rhythms; Clinical; Data; Death; Delta Wave; Delta Wave sleep; Dependent drinker; Diagnosis; Diurnal Rhythm; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Therapy; Drugs; Dysfunction; EEG; Electroencephalography; Encephalon; Encephalons; Ethanol dependence; Functional disorder; Gender; History; Hour; Human, Adult; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Impaired Driving; Insomnia; Insomnia Disorder; Investigators; Laboratories; Measures; Medication; Melatonin; Monitor; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurontin; Nyctohemeral Rhythm; Outcome; PBO; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Physiopathology; Placebos; Programs (PT); Programs [Publication Type]; Psyche structure; Public Health; Randomized; Recording of previous events; Regulation; Relapse; Research; Research Personnel; Researchers; Risk; Risk Factors; Science; Screening procedure; Sham Treatment; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Hypopnea; Sleep disturbances; Sleep-Disordered Breathing; Sleeplessness; Slow-Wave Sleep; Time; Twenty-Four Hour Rhythm; Visit; Wakefulness; Wakefulnesses; actigraphy; adult human (21+); alcohol addiction; alcohol dependency; alcohol withdrawal; alcohol-dependent; base; chronic disease/disorder; chronic disorder; circadian; circadian process; cost; daily biorhythm; design; designing; diurnal variation; drinking; driving while impaired; drug/agent; effective therapy; ethanol addiction; ethanol dependency; ethanol withdrawal; ethanol-dependent; follow-up; gabapentin; impaired driving performance; improved; indexing; insight; mental; pathophysiology; phase 1 study; problem drinker; programs; public health medicine (field); randomisation; randomization; randomly assigned; response; screening; screenings; sex; sham therapy; sleep abnormalities; sleep problem; substance use; withdrawal from alcohol",Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence,,16117,ZAA1,Special Emphasis Panel,,4,438149,
7753238,R01,AA,5,,02/01/2010,01/31/2011,PA-04-100,5R01AA016213-19,,NIAAA:612219;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,TEMPE,UNITED STATES,PSYCHOLOGY,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"CHASSIN, LAURIE A;",1895477;,5R01AA016213,09/30/1987,01/31/2011,"0-11 years old; 12-20 years old; 21+ years old; AOD use; Accounting; Active Follow-up; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Age; Alcohol or Other Drugs use; Alcoholic; Alcoholism; Belief; Boozer; Causality; Child; Child Youth; Children (0-21); Computer Assisted; Data; Dependence; Dependent drinker; Development; Disease; Disorder; Drug effect disorder; Etiology; Event; Fathers; Generations; Heterogeneity; Human, Adult; Human, Child; Individual Differences; Interview; Longitudinal Studies; Mails; Marriage; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Modeling; Natural History; Neighborhoods; Outcome; Parenting; Parenting behavior; Parents; Participant; Pathway interactions; Performance; Prevention; Process; Prospective Studies; Psychopathology; Records; Regulation; Research; Risk; Risk Factors; Role; Sampling; Schools; Social Environment; Socialization; Socializations; Specificity; Stress; Substance Use Disorder; Symptoms; Temperament; Testing; Transmission; abnormal psychology; adolescence (12-20); adolescent substance use; adult human (21+); children; children of alcoholics; computer aided; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug action; emerging adult; follow-up; grandparent; high risk; juvenile; juvenile human; long-term study; longitudinal design; motivational processes; next generation; pathway; peer; problem drinker; psychologic; psychological; satisfaction; social climate; social context; social role; socioenvironment; substance use; teenage; transmission process; youngster; youth substance use",Substance Use Among Children of Alcoholics,,16213,ZRG1,Special Emphasis Panel,,19,612219,
7753912,R01,AA,5,,01/01/2010,12/31/2010,PA-07-071,5R01AA016346-02,,NIAAA:385131;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"CRUM, ROSA M;",1893133;,5R01AA016346,01/01/2009,12/31/2012,"AOD use; Affective Disorders; African American; Afro American; Afroamerican; Age; Age of Onset; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; Analysis, Data; Anxiety; Anxiety Disorders; Behavior; Black Populations; Black or African American; Bryophyta; Bryophyte; Characteristics; Chemical Class, Alcohol; Chicanas; Chicanos; Classification; Clinical; Clinical Research; Clinical Study; Complex; Conduct Disorder; Country; DSM-IV; DSM4; Data; Data Analyses; Data Set; Dataset; Dependence; Depression; Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Disease; Disorder; Drugs; Dysthymic Disorder; Epidemiology, Family Medical History; EtOH drinking; Ethanol dependence; Ethnic Origin; Ethnicity; Ethnicity aspects; Event; Family Medical History; Family history of; Female; Gender; Generalized Anxiety Disorder; Goals; Grant; Health; Health Insurance; Hispanic Populations; Hispanics; Hispanics or Latinos; Immigrations; In-Migration; Incidence; Individual; Latino Population; Major Depressive Disorder; Manias; Manic; Manic State; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mental Depression; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Mexican Americans; Mood Disorders; Moods; Mosses; NIH Program Announcements; National origin; Non-Hispanic; Not Hispanic or Latino; Outcome; Panic Disorder; Pathway interactions; Pattern; Personality; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prevalence; Preventive Intervention; Probability; Program Announcement; Psyche structure; Psychiatric Diagnosis; Psychiatric Disease; Psychiatric Disorder; Race; Racial Group; Raspberries; Raspberry; Relative; Relative (related person); Reporting; Risk; SUBGP; Sample Size; Sampling; Sampling Studies; Selection Bias; Social Functioning; Social Phobia; Spanish Origin; Specific Phobia; Staging; Stocks, Racial; Structure; Subgroup; Substance Use Disorder; Survey Instrument; Surveys; Survival Analyses; Survival Analysis; Symptoms; Syndrome; Systematics; Techniques; Testing; Time; Tobacco Consumption; Tobacco use; United States; Unspecified Mental Disorder; Variant; Variation; Woman; Work; addiction; alcohol addiction; alcohol dependency; alcohol epidemiology; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol related problem; alcohol use; alcohol use disorder; alcohol use initiation; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; black American; disability; disease/disorder; drinking; drinking behavior; drug/agent; dysthymia; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol use disorder; ethanol-dependent; ethnic minority; ethnic minority population; etoh use; hazardous alcohol use; high risk; hispanic community; hypomania; improved; information gathering; major depression; male; men; men's; mental; mental illness; panic anxiety syndrome; pathway; population based; prevent; preventing; preventional intervention strategy; problem drinking; psychological disorder; public health relevance; racial and ethnic; racial/ethnic; response; sex; substance use; time use; trend",Comorbid Patterns with Alcohol Use Disorders," PROJECT NARRATIVE Anxiety and mood problems are among the most common mental health disorders worldwide. These problems may increase the chance that other conditions occur such as addictions to alcohol. Using information gathered from one of the largest surveys to evaluate the presence of these symptoms among residents of the United States, we will study these relationships by different groups, in order to help understand if some individuals are more or less vulnerable to these conditions. This study aims to evaluate the complex relationships that may be occurring between mood, anxiety and drinking behavior with the hope that understanding these relationships better will help us identify improved methods for preventing and intervening with these conditions.",16346,BGES,Behavioral Genetics and Epidemiology Study Section,,2,385131,
7743583,R01,AA,5,,01/01/2010,12/31/2010,PA-03-162,5R01AA016560-04,,NIAAA:325215;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,RALEIGH,UNITED STATES,GENETICS,04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"MACKAY, TRUDY F;",1891713;,5R01AA016560,01/01/2007,12/31/2011,"ANOVA; Address; Affect; Alcohol abuse; Alcohol dependence; Alcoholism; Alcohols; Alleles; Allelism Test; Allelomorphs; Analysis of Variance; Architecture; Award; Behavior; Behavioral; Biological Models; Body Tissues; Candidate Disease Gene; Candidate Gene; Cardiovascular Diseases; Cessation of life; Chemical Class, Alcohol; Chronic; Complementation Test; Complex; DNA; Data; Death; Deoxyribonucleic Acid; Development; Drosophila; Drosophila genus; Drosophila melanogaster; Economics; Engineering / Architecture; Environmental Factor; Environmental Risk Factor; Ethanol dependence; Exploratory/Developmental Grant; Flies; Fruit Fly, Drosophila; Future; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Complementation Test; Genetic Models; Genetic Polymorphism; Genetic defect; Genetics, Population; Genome; Genome Scan; Genotype; Goals; Heterogeneity, Population; Human; Human, General; Individual; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Injury; Insertion Mutation; Man (Taxonomy); Man, Modern; Maps; Medical; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular; Mutation; Nature; Neurologic; Neurological; Nucleotides; P element; Parenting; Parenting behavior; Pattern; Phenotype; Phosphorus; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Genetics; Population Heterogeneity; Predisposing Factor; Programs (PT); Programs [Publication Type]; QTL; Quantitative Trait Loci; R21 Mechanism; R21 Program; Research; Resistance; Resolution; Staging; Stress; Systems Biology; Testing; Tissues; Traffic accidents; Trans Test; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenic Organisms; United States; Variance Analyses; Variant; Variation; alcohol addiction; alcohol behavior; alcohol dependency; alcohol effect; alcohol induced behavior; alcohol problem; alcohol related behavior; alcohol sensitivity; alcohol-dependent; base; cardiovascular disorder; comparative genomics; design; designing; diverse populations; environmental risk; ethanol abuse; ethanol addiction; ethanol behavior; ethanol dependency; ethanol effect; ethanol induced behavior; ethanol related behavior; ethanol sensitivity; ethanol-dependent; fly; fruit fly; gastrointestinal; genome mutation; hazardous alcohol use; heterogeneous population; insight; molecular marker; novel; polymorphism; problem drinking; programs; resistant; response; sensitivity to alcohol; sensitivity to ethanol; social; trait; transgenic",Genetics of Alcohol Sensitivity in Drosophila,,16560,NAL,Neurotoxicology and Alcohol Study Section,,4,325215,
7753250,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA016789-03,,NIAAA:332230;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,PSYCHOLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"BOEHM, STEPHEN LEE;",8649580;,5R01AA016789,01/01/2009,12/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Absolute ethanol; Acquired brain injury; Agonist; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol, Ethyl; Alcoholic; Alcoholism; Aminalon; Aminalone; Anterior; Baclofen; Behavior; Behavioral; Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-; Blotting, Western; Boozer; Brain; Brain Diseases; Brain Disorders; Brain Injuries; Brain region; Butanoic acid, 4-amino-; Cephalic; Chlorophenyl GABA; Chronic; Cranial; Data; Dependence; Dependent drinker; Development; Dopamine; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug effect disorder; Drugs; ETOH; Electromagnetic, Laser; Encephalon; Encephalon Diseases; Encephalons; EtOH drinking; Ethanol; Ethanol dependence; GABA; Gene Expression; Goals; Grain Alcohol; Heavy Drinking; Human; Human, General; Hydroxytyramine; Injection of therapeutic agent; Injections; Intake; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Knowledge; Lasers; Lead; Liquid substance; Literature; Maintenance; Maintenances; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Mediating; Medication; Methods and Techniques; Methods, Other; Methylcarbinol; Mice; Mice, Mutant Strains; Microdissection; Microinjections; Modeling; Monitor; Murine; Mus; Mutant Strains Mice; N,N,6-trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate; Nervous System, Brain; Neurobiology; Nucleus Accumbens; PCP-GABA; PCR; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Polymerase Chain Reaction; Prefrontal Cortex; Procedures; Property; Property, LOINC Axis 2; Radiation, Laser; Receptor Protein; Relapse; Relative; Relative (related person); Rodent; Rodentia; Rodentias; Role; Self Administration; Structure; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Time; Tissue Harvesting; Transcript; Ventral Tegmental Area; Water Intake; Water consumption; Western Blotting; Western Blottings; Western Immunoblotting; Work; alcohol addiction; alcohol addiction therapy; alcohol dependence therapy; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alcoholism therapy; base; beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid; beta-(p-Chlorophenyl)-gamma-aminobutyric Acid; binge alcohol consumption; binge drinker; binge drinking; bout drinker; brain damage; brain lesion (from injury); drink heavily; drinking; drug action; drug/agent; episodic drinker; episodic drinking; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experiment; experimental research; experimental study; extreme drinking; fluid; gamma-Aminobutyric Acid; hazardous alcohol use; heavy alcohol use; heavy metal Pb; heavy metal lead; liquid; mRNA Expression; mesolimbic system; mouse model; mouse mutant; neuroadaptation; neurobiological; neurobiological mechanism; pathway; problem drinker; problem drinking; protein blotting; protein expression; public health relevance; receptor; research study; social role; tool; treatment strategy; ventral tegmentum; zolpidem",GABAergic Mechanisms in the Modulation of Binge-Like Ethanol Intake in Mice," The proposed work will contribute to our general knowledge concerning the involvement of GABA circuits in the ventral tegmental area, nucleus accumbens, and prefrontal cortex in the maintenance of binge-like ethanol intake. It will advance our understanding of the neurobiological factors associated with the transition from casual alcohol use to alcohol abuse and dependence in humans, and may ultimately lead to better pharmacological treatment strategies for alcoholism. ",16789,NAL,Neurotoxicology and Alcohol Study Section,,3,332230,
7758846,R01,AA,5,,02/01/2010,01/31/2011,DA-06-004,5R01AA016887-04,,NIAAA:327553;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BINGHAMTON,UNITED STATES,PSYCHOLOGY,24,090189965,US,NY,139026000,STATE UNIVERSITY NEW YORK BINGHAMTON,"SPEAR, LINDA PATIA;",1868306;,5R01AA016887,02/15/2007,01/31/2012,"12-20 years old; 20 year old; 21+ years old; Absolute ethanol; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Age; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Area; Attenuated; Behavior; Biological; Brain; Brain region; Buffers; Characteristics; Chemical Class, Alcohol; Chronic stress; Common Rat Strains; Data; Development; ETOH; Encephalon; Encephalons; Epidemiology, Family Medical History; EtOH drinking; Ethanol; Exhibits; Expectancy; Family Medical History; Family history of; Fore-Brain; Forebrain; Grain Alcohol; Human; Human, Adult; Human, General; Individual Differences; Intake; Investigators; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Methylcarbinol; Moods; Motivation; Nervous; Nervous System, Brain; Nicotine; Pattern; Peer Pressure; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reading; Relative; Relative (related person); Reporting; Research Personnel; Researchers; Rewards; Risk Factors; Rodent Model; SAMHSA; Social Behavior; Social Environment; Social Facilitation; Social Interaction; Social Values; Source; Stimulus; Stress; Striatum, Ventral; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Survey Instrument; Surveys; Testing; Time; United States Substance Abuse and Mental Health Services Administration; Ventral Striatum; Work; Youth Drinking; adolescence (12-20); adolescent alcohol use; adolescent drinking; adult human (21+); alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol product use; alcohol reinforcement; alcohol reward; alcohol sensitivity; alcohol use; alcoholic beverage consumption; alcoholic drink intake; amygdaloid nuclear complex; binge alcohol consumption; binge drinking; conditioning; coping; drinking; episodic drinking; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol reinforcement; ethanol reward; ethanol sensitivity; ethanol use; ethanol-induced social facilitation; etoh use; experience; exposed to alcohol; exposure to alcohol; hedonic; juvenile; juvenile human; model organism; neural; neurobehavioral; peer; programs; relating to nervous system; role model; sensitivity to alcohol; sensitivity to ethanol; social; social climate; social context; social neuroscience; sociobehavior; sociobehavioral; socioenvironment; teen drinking; teenage; teenage drinking; twenty year old; underage drinking",Ethanol-Induced Social Facilitation in Adolescence: Social and Ethanol Reward,,16887,ZDA1,Special Emphasis Panel,,4,327553,
7758849,R01,AA,5,,01/01/2010,12/31/2010,PA-07-071,5R01AA016960-02,,NIAAA:371653;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,SEATTLE,UNITED STATES,NONE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HILL, KARL GORDON;",8191972;,5R01AA016960,01/15/2009,12/31/2011,"0-11 years old; 12-20 years old; 21 year old; 21+ years old; Acceleration; Adolescence; Adolescent; Adolescent Youth; Adult; Age; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Behavior; Characteristics; Child; Child Youth; Childhood; Children (0-21); Crime; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dependence; Development; Diagnostic; Equilibrium; EtOH drinking; Ethanol dependence; Event; Family; Gender; Health behavior; Human, Adult; Human, Child; Individual; Intervention; Intervention Strategies; Life; Link; Longitudinal Studies; Marriage; Measurement; Measures; Modeling; Neighborhoods; Occupational; Outcome; Parents; Participant; Pattern; Predictive Factor; Preventive; Records; Reporter; Risk; Role; Schools; Social Development; Work; Youth; Youth 10-21; adolescence (12-20); adolescent alcohol; adult human (21+); adult youth; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol misuse; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; balance; balance function; bear children; bearing children; binge alcohol consumption; binge drinking; child bearing; childbearing; children; clinical data repository; clinical data warehouse; cost; court; data repository; design; designing; early alcohol use; episodic drinking; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol misuse; ethanol product use; ethanol use; ethanol-dependent; etoh use; hazardous alcohol use; informant; interventional strategy; juvenile; juvenile human; long-term study; pediatric; peer; problem drinking; public health relevance; relational database; social; social role; teacher; teenage; theories; twenty-one year old; young adult; youngster","Understanding Alcohol Misuse, Abuse and Dependence in Young Adulthood"," The proposed study examines the occurrence and course of binge drinking, alcohol abuse and alcohol dependence in young adulthood (ages 21 to 30) in the Seattle Social Development Project panel. The study seeks to understand the relationship between childhood and adolescent patterns of alcohol use and young adult binge drinking, alcohol abuse and alcohol dependence through age 30, and the role of social- developmental factors in influencing these patterns. The study will provide information of use to those designing preventive and treatment interventions for alcohol misuse, alcohol abuse and alcohol dependence.",16960,ZRG1,Special Emphasis Panel,,2,371653,
7754124,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA016969-02,,NIAAA:269522;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,Beltsville,UNITED STATES,,05,021883350,US,MD,207053111,PACIFIC INSTITUTE FOR RES AND EVALUATION,"RUSSELL, CRISTEL ANTONIA;",8771533;,5R01AA016969,01/01/2009,12/31/2011,"12-20 years old; 16 year old; 21 year old; 21+ years old; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adolescence; Adult; Advertising; Affect; Age; Alcohol Drinking; Alcohol consumption; Alcohols; Americas; Attention; Attitude; Auditory; Behavior; Behavioral; Belching; Belchings; Belief; Cell Communication and Signaling; Cell Signaling; Cessation of life; Characteristics; Chemical Class, Alcohol; Consumer Advocacy; Death; Development; Dissociation; Drug abuse; Education; Educational aspects; Environment; Eructation; EtOH drinking; Experimental Designs; Exposure to; Film; Government; Guidelines; HIV; HTLV-III; Happiness; Happinesses; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Image; Immunologic Deficiency Syndrome, Acquired; Individual; Industry; Influentials; Informal Social Control; Intracellular Communication and Signaling; Knowledge; LAV-HTLV-III; Lead; Learning; Link; Lymphadenopathy-Associated Virus; Measures; Memory; Method LOINC Axis 6; Methodology; Modality; Modeling; Music; Musics; Nature; Participant; Pb element; Perception; Peripheral; Persuasion; Persuasive Communication; Phase; Play; Policies; Pre-Post Tests; Prevention; Prevention strategy; Preventive strategy; Procedures; Process; Production; Programs (PT); Programs [Publication Type]; Research; Role; Route; SAMHSA; Self Regulation; Series; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Social Behavior; Social Control, Informal; Source; Staging; Stimulus; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Survey Method; Survey Methodology; TV; Teen; Teenagers; Teens; Television; Testing; Tests, Pre-Post; Time; Training; United States Substance Abuse and Mental Health Services Administration; Virus-HIV; Visual; Youth; Youth 10-21; Youth Drinking; abuse of drugs; abuses drugs; adolescence (12-20); adolescent alcohol; adolescent alcohol use; adolescent drinking; adult human (21+); alcohol advertising; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol monitoring; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; biological signal transduction; design; designing; digital; drinking; drinking behavior; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; heavy metal Pb; heavy metal lead; imaging; information processing; innovate; innovation; innovative; literacy; novel; positive attitude; programs; psychologic; psychological; public health relevance; research study; response; sixteen year old; social role; sociobehavior; sociobehavioral; teen drinking; teen years; teenage; teenage drinking; tool; twenty-one year old; underage drinking",Effect of Alcohol Placements in Television Programming," PROJECT NARRATIVE This research studies how alcohol messages embedded in television programming affect teenagers' drinking attitudes, beliefs, and behaviors. Teenagers are susceptible to television influences and alcohol is increasingly present in the content of television programs. We investigate the impact on teenagers of different types of alcohol messages embedded in a television series episode and we also investigate whether warnings about the presence of alcohol messages change the relation between exposure and teenagers' drinking attitudes and intentions.",16969,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,2,269522,
7746463,R01,AA,5,,12/01/2009,11/30/2010,PA-07-070,5R01AA017461-02,,NIAAA:352688;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"JUNE, HARRY L;",1874309;,5R01AA017461,12/15/2008,11/30/2013,"Abstinence; Acute; Affective; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anhedonia; Antidepressant Agent; Antidepressant Drugs; Antidepressant Drugs, Tricyclic; Antidepressants; Antidepressants, Tricyclic; Antidepressive Agents; Antidepressive Agents, Tricyclic; Attenuated; Bed Nucleus of Stria Terminalis; Behavior; Brain; Cell Nucleus; Chemical Class, Alcohol; Chronic; Common Rat Strains; DOV 216,303; DOV 216303; Data; Dependence; Depression; Drugs; Emotional Depression; Encephalon; Encephalons; EtOH drinking; Ethanol dependence; Evaluation; FOS gene; G0S7; Heavy Drinking; Human; Human Volunteers; Human, General; Individual; Intake; Lead; Light; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Medication; Mental Depression; Microinjections; Modeling; Nervous System, Brain; Neurobiology; Nucleus; Nucleus Accumbens; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Pre-Clinical Model; Preclinical Models; Prefrontal Cortex; Property; Property, LOINC Axis 2; Protooncogene FOS; Publishing; Rat; Rattus; Rodent Model; SCHED; SSRI; Schedule; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Self Stimulation; Series; Site; Stria Terminalis Nucleus; Structure of terminal stria nuclei of preoptic region; Swimming; Symptoms of depression; Technology; Testing; Tricyclic Antidepressive Agents; Volunteers, Human; Withdrawal; abstaining from alcohol; abstaining from ethanol; abstinence from alcohol; abstinence from ethanol; alcohol abstinence; alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; amygdaloid nuclear complex; binge alcohol consumption; binge drinking; c fos; c-fos Gene; c-fos Proto-Oncogenes; clinical efficacy; depressive; depressive symptoms; deprivation; drink heavily; drinking; drug/agent; episodic drinking; ethanol abstinence; ethanol abuse; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-dependent; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; hazardous alcohol use; heavy alcohol use; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; monoamine; neurobiological; neurobiological mechanism; novel; phase 1 study; pleasure; pre-clinical; preclinical; problem drinking; prototype; public health relevance; serotonin reuptake inhibitor; uptake; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Efficacy of Novel Triple Uptake Inhibitors in Treating Alcoholism and Depression, Project Narrative The present proposal will evaluate a series of novel antidepressant medications for their capacity to reduce excessive alcohol drinking and alcohol abstinence effects in a rodent model of alcohol abuse. The primary objective of the proposal will be to successfully identify agents that may be used to treat both depression and alcohol addiction in humans.,17461,NAL,Neurotoxicology and Alcohol Study Section,,2,352688,
7759647,R01,AA,5,,01/01/2010,12/31/2010,PA-07-070,5R01AA017656-02,,NIAAA:386193;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,WORCESTER,UNITED STATES,PSYCHIATRY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"TAPPER, ANDREW R;",2110938;,5R01AA017656,01/15/2009,12/31/2013,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Absolute ethanol; Acetylcholine; Acute; Affinity; Agonist; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcohol, Ethyl; Alcoholic; Alcohols; Area; Ataxia; Ataxy; Behavioral; Behavioral Assay; Biology; Boozer; Brain; Brain region; Cessation of smoking; Chemical Class, Alcohol; Chronic; Coordination Impairment; Coupled; D alpha 3, Drosophila; Dependence, Nicotine; Dependent drinker; Drosophila acetylcholine receptor alpha-subunit; Drugs; Dyssynergia; ETOH; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; EtOH drinking; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethanol; Ethanol dependence; Exons; Genes; Genotype; Goals; Grain Alcohol; Hibernation, Artificial; Hydrogen Oxide; Hypothermia; Knock-out; Knockout; Knockout Mice; Locomotion; Mammals, Mice; Measures; Mediating; Medication; Mesencephalon; Methylcarbinol; Mice; Mice, Knock-out; Mice, Knockout; Mid-brain; Midbrain; Midbrain structure; Molecular; Molecular Target; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Null Mouse; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Physiologic; Physiological; Physiology; Point Mutation; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Psychological reinforcement; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Receptor Activation; Receptor Protein; Recovery; Reinforcement; Reinforcement (Psychology); Rewards; Role; Saline; Saline Solution; Self Administration; Slice; Testing; Therapeutic; Tobacco smoke; Variant; Variation; Ventral Tegmental Area; Water; acetylcholine receptor alpha-subunit, Drosophila; addiction; alcohol addiction; alcohol behavior; alcohol dependency; alcohol effect; alcohol induced behavior; alcohol ingestion; alcohol intake; alcohol product use; alcohol related behavior; alcohol response; alcohol reward; alcohol use; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; base; cease smoking; cigarette smoking; desensitization; design; designing; drinking; drug/agent; ethanol addiction; ethanol behavior; ethanol consumption; ethanol dependency; ethanol drinking; ethanol effect; ethanol induced behavior; ethanol ingestion; ethanol intake; ethanol product use; ethanol related behavior; ethanol response; ethanol reward; ethanol use; ethanol-dependent; etoh use; experiment; experimental research; experimental study; hypothermia, induced; hypothermia, natural; induced hypothermia; insight; mouse model; nAChR subunit; natural hypothermia; neuronal; nicotine addiction; preference; problem drinker; public health relevance; receptor; research study; response; response to alcohol; response to ethanol; smoke cigarette; smoking cessation; social role; varenicline; ventral tegmentum",Neuronal nicotinic acetylcholine receptors and the response to alcohol," Nicotine and alcohol are the two most widely co-abused drugs in the world suggesting that there is a functional interaction between nicotine, the primary addictive component of tobacco smoke, and ethanol. The goal of the proposed project is to understand the underlying functional interaction between these two drugs on a molecular, neuronal, and behavioral level. The insights gained from this project should help identify molecular targets for alcohol cessation therapeutics.",17656,NAL,Neurotoxicology and Alcohol Study Section,,2,386193,
7809662,R01,AA,5,,02/01/2010,01/31/2011,PA-07-070,5R01AA018071-02,,NIAAA:299079;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,LONG BEACH,UNITED STATES,,38,622027209,US,CA,908225201,SOUTHERN CALIFORNIA INST FOR RES/EDUC,"SAID, HAMID M;",1878273;,5R01AA018071,05/01/2009,01/31/2014,"2-Keto-4-Hydroxyglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase Complex; 2-Oxoglutarate[{..}]lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating); 2-Oxoisocaproate Dehydrogenase; 2-Oxoisovalerate Dehydrogenase (Lipoamide); 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Absolute ethanol; Acinar Cell; Aciner Cells; Address; Affect; Ailmentary System; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcoholic; Alimentary System; Alpha-Keto Acid Dehydrogenase; Anemia, Megaloblastic; Aneurin; Apoptosis; Apoptosis Pathway; Autoregulation; B9 endocrine pancreas; BCKA Decarboxylase; Beta Cell; Body Tissues; Boozer; Branched Chain Alpha-Keto Acid Decarboxylase; Branched Chain Ketoacid Dehydrogenase; Branched-Chain 2-Oxo Acid Dehydrogenase; Branched-Chain Keto Acid Dehydrogenase; Branched-Chain Oxo-Acid Dehydrogenase; Carrier Proteins; Cell Culture Techniques; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell/Tissue, Immunohistochemistry; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chemicals; Chronic; Clinical; Country; Culture Media; DNA Molecular Biology; Dependent drinker; Development; Diabetes Mellitus; Digestive System; Digestive System (All Sites); Disease; Disorder; Drugs; ETOH; Endocrine; Energy Expenditure; Energy Metabolism; Enzymes; EtOH drinking; Ethanol; Event; Gastrointestinal Body System; Gastrointestinal Tract, Pancreas; Gene Expression; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetics, in situ Hybridization; Glycolaldehydetransferase; Grain Alcohol; Growth and Development; Growth and Development function; Homeostasis; Human; Human Activities; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Impairment; In Situ Hybridization; Insulin Cell; Insulin Secreting Cell; Intermediary Metabolism; Investigation; Islands of Langerhans; Islet Cells; Islets of Langerhans; Ketoglutarate Dehydrogenase Complex; Kinetic; Kinetics; Knockout Mice; Knowledge; Lead; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Megaloblastic Anemia; Membrane Protein Traffic; Membrane Traffic; Messenger RNA; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Methylcarbinol; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Micronutrients; Modeling; Molecular; Molecular Biology; Molecular Transport; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mutation; Nesidioblasts; New York; Null Mouse; Nutrition; Nutritional; Nutritional Science; Organ; Organ System, Gastrointestinal; Oxidative Stress; Oxoglutarate Dehydrogenase; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pancreatic beta Cell; Pancreatitis; Pars endocrina pancreatis; Pathology; Patients; Pattern; Pb element; Pentosephosphates; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiological Homeostasis; Physiology; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; RNA, Messenger; Reaction; Regulation; Regulatory Element; RegulatoryElement; Relative; Relative (related person); Reporting; Role; Schools, Medical; Science of nutrition; Sedoheptulose-7-phosphate[{..}]D-glyceraldehyde-3-phosphate glycolaldehydetransferase; Specificity; Stress; Structure of beta Cell of islet; Subcellular Process; Syndrome; Temperature; Testing; Thiamin Metabolism; Thiamin Metabolism Pathway; Thiamine; Thiamine Deficiency; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride; Tissues; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenes; Transgenic Mice; Transketolase; Transport Process; Transport Proteins; Transporter Protein; Vit B1; Vitamin B 1; Vitamin B1; Vitamins; Water-Soluble Vitamin; Wild Type Mouse; Work; alcohol effect; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; alpha-Ketoglutarate Dehydrogenase; alpha-Ketoglutarate Dehydrogenase Complex; base; beta cell development; cell biology; cell type; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; cofactor; diabetes; diabetic patient; disease/disorder; drug/agent; endocrine pancreas; endocrine pancreas development; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experiment; experimental research; experimental study; extracellular; feeding; gastrointestinal system; gene product; genome mutation; growth media; heavy metal Pb; heavy metal lead; in situ Hybridization Staining Method; insulin secretion; islet development; islet progenitor; mRNA; medical schools; mouse model; mutant; nutrition; pancreas beta cell; pancreas development; pentose phosphate; problem drinker; public health relevance; pyrophosphatase; pyruvate dehydrogenase; research study; social role; thiamin; uptake",Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol,,18071,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,2,299079,
7795074,R01,AG,5,,02/01/2010,01/31/2011,,5R01AG012745-15,,NIA:628189;,2010,NATIONAL INSTITUTE ON AGING,,PHILADELPHIA,UNITED STATES,OBSTETRICS & GYNECOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"FREEMAN, ELLEN W;",1882251;,5R01AG012745,02/10/1996,01/31/2011,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; AHH; AHRR; ARO; ARO1; Accounting; African; African American; Afro American; Afroamerican; Age; Aging; Androst-4-en-17beta-ol-3-one; Antiheparin Factor; Aquadiol; Behavioral; Behavioral Symptoms; Black Populations; Black or African American; Blood Platelet Factor IV; Blood Sample; Blood platelet factor 4; Blood specimen; Body Weight; CP11; CP12; CPV1; CY11; CYAR; CYP1; CYP19; CYP19A1; CYP19A1 gene; CYP1A1; CYP1A1 gene; CYP1A2; CYP1A2 gene; CYP1B1; Care, Health; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Change of Life, Female; Chemokine (C-X-C motif) Ligand 4; Chemotherapy-Hormones/Steroids; Cohort Studies; Concurrent Studies; Data; Delta4-androsten-17beta-ol-3-one; Depressed mood; Depression; Dimenformon; Diogyn; Diogynets; Distress; EDS-4-hydroxylase; Emotional Depression; Endocrine Gland Secretion; Enrollment; Environmental Factor; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Metabolism; Estrogenic Agents; Estrogenic Compounds; Estrogens; Evaluation; Factor 4; Genes; Genetic; Genetic Polymorphism; Healthcare; Heparin Neutralizing Protein; Hormonal; Hormones; Hot flushes; Individual; Investigation; Lead; Link; Medical; Memory Deficit; Memory impairment; Menopausal Symptom; Menopause; Menstrual cycle; Mental Depression; Methods; Modeling; Morbidity; Morbidity - disease rate; Obesity; Occidental; Ovarian; Ovocyclin; Ovocylin; P-450AROM; P1-450; P3-450; P450(PA); P450-C; P450DX; P450D\X; Pb element; Phase Transition; Platelet Factor 4; Polymorphism (Genetics); Polymorphism, Genetic; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Pre-Menopause; Pre-menopausal Period; Premenopausal; Premenopausal Period; Premenopause; Preventive; Progress Reports; Progynon; Race; Racial Group; Recombinant Platelet Factor 4; Reports, Progress; Role; Senescence; Severities; Sleep; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Staging; Stocks, Racial; Symptoms; Symptoms of depression; Testosterone; Therapeutic; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Testosterone; Time; Trans-Testosterone; Variant; Variation; Vasomotor; Woman; Work; adiposity; black American; cofactor; cohort; corpulence; corpulency; corpulentia; cytochrome P-450 CYP1B1; cytochrome P450 CYP1B1; cytochrome P4501B1; depressed; depressive; depressive symptoms; enroll; environmental risk; estradiol 17-sulfate 4-hydroxylase; estradiol-4-hydroxylase; estrogen 4-hydroxylase; experience; gamma-Thromboglobulin; heavy metal Pb; heavy metal lead; hot flash; inhibin B; innovate; innovation; innovative; menopausal; mid life; mid-life; middle age; middle aged; midlife; obese; obese people; obese person; obese population; platelet factor IV; polymorphism; post-menopausal; postmenopausal; pre-menopausal; prospective; psychologic; psychological; race differences; racial difference; reproductive; sadness; senescent; social role; trend; white race",Epidemiologic Study of the Late Reproductive Years,,12745,ECD,Epidemiology of Chronic Diseases Study Section,,15,628189,
7794912,R01,AG,5,,02/01/2010,01/31/2011,,5R01AG023742-05,,NIA:382887;,2010,NATIONAL INSTITUTE ON AGING,,PHILADELPHIA,UNITED STATES,PSYCHOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"WOODRUFF-PAK, DIANA S;",1951019;,5R01AG023742,04/01/2006,01/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; AMPA Receptors; Activities of Daily Living; Activities of everyday life; Address; Affect; Age; Age-associated cognitive decline; Age-associated memory impairment; Age-related cognitive decline; Aged 65 and Over; Aging; Aminalon; Aminalone; Ammon Horn; Associative Learning; Astrocytes; Astrocytus; Astroglia; Axon; Behavior; Behavioral; Benign senescent forgetfulness; Biological Models; Blinking; Brain; Brain region; Butanoic acid, 4-amino-; C57BL/6 Mouse; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Count; Cell Nucleus; Cell Number; Cerebellar Cortex; Cerebellar cortex structure; Cerebellum; Cognitive; Cognitive aging; Conditioning, Classical; Conditionings, Classical; Cornu Ammonis; Dendrites; Elderly; Elderly, over 65; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Fiber; GABA; Genetic Alteration; Genetic Change; Genetic defect; Genome Mappings; Glia; Glial Cells; Hippocampus; Hippocampus (Brain); Human; Human, General; Impairment; Individual; Infusion; Infusion procedures; Investigators; Ion Channels, Calcium; Knowledge; Kolliker's reticulum; Learning; Length of Life; Life; Life Expectancy; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Longevity; Mammals, Mice; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mappings, Genome; Measures; Memory; Mice; Mice, Mutant Strains; Model System; Modeling; Models, Biologic; Morphology; Mouse Strains; Murine; Mus; Mutant Strains Mice; Mutation; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurological; Neurons; Neurophysiology / Electrophysiology; Non-neuronal cell; Nucleus; Organism; Oryctolagus cuniculus; Outcome; Pavlovian conditioning; Performance; Preparation; Procedures; Process; Programs (PT); Programs [Publication Type]; Purkinje Cells; Purkinje's Corpuscles; Pyramidal Cells; Pyramidal neuron; Rabbit, Domestic; Rabbits; Receptors, AMPA; Receptors, Calcium Channel Blocker; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Senescence; Slice; Structure; Synaptic Transmission; System; System, LOINC Axis 4; Testing; United States; V (voltage); VDCC; Variant; Variation; Voltage-Dependent Calcium Channels; advanced age; age dependent; age effect; age related; aging effect; base; behavior test; behavioral test; cerebellar Purkinje cell; classical conditioning; cognitive function; conditioned fear; conditioning; daily living functionality; early onset; elders; eye blink; eyeblink; fear conditioning; functional ability; functional capacity; gamma-Aminobutyric Acid; genome mutation; geriatric; granule cell; hippocampal; hippocampal pyramidal neuron; inhibitory neuron; late life; later life; life span; lifespan; living system; locomotor learning; long term depression; motor learning; mouse model; mouse mutant; mutant; nerve cement; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; normal aging; older adult; older person; programs; senescent; senior citizen; social role; voltage",Mechanisms of Associative Learning in Aging: Mouse Models,,23742,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,5,382887,
7798129,R01,AG,5,,02/01/2010,12/31/2010,,5R01AG026107-05,,NIA:337965;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"LERI, ANNAROSA ;",6410155;,5R01AG026107,02/15/2006,12/31/2010,"Age; Age of Onset; Aging; Alleles; Allelomorphs; Amino Acids; Animal Model; Animal Models and Related Studies; Animals; ApoE Receptor; Apoptosis; Apoptosis Pathway; Apoptotic; Appearance; Attenuated; Autoregulation; Binding; Binding (Molecular Function); Biological Preservation; Biology of Aging; Body Tissues; CAM 120/80; CD117 Antigens; Cadherin-1; Cadherins; Cardiac; Cardiac Ventricles; Causality; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cessation of life; Chemosensitization; Chemosensitization/Potentiation; Commit; Complex; Coronary; Coupled; Couples; Crowding; Cues; Cysteine; Death; Defect; Development; Disorder of muscle, unspecified; Dysfunction; E-Cadherin; Epidermis; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Equilibrium; Etiology; Evaluation; Family; Feedback; Fibroblasts; Functional disorder; GFAC; Gene Expression; Generalized Growth; Generations; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic Markers; Genetic defect; Glycolates; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HTRPY; Half-Cystine; Hand; Heart; Heart Ventricle; Heart failure; Homeostasis; Homing; Hypertrophy; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; L-Cysteine; LDL-Receptor Related Protein 1; Laboratories; Left; Length of Life; Life; Lipids; Lipoprotein Receptor; Liver Cell Adhesion Molecules; Longevity; Low Density Lipoprotein Receptor-Related Protein; Low-Density-Lipoprotein Receptor-Related Protein-1; Mammals, Mice; Mast Cell Growth Factor Receptor; Mediating; Membrane; Mice; Mice, Mutant Strains; Modality; Modeling; Modification; Molecular; Molecular Interaction; Mother Cells; Murine; Mus; Muscle Cells; Muscle Cells, Mature; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscle, Cardiac; Muscle, Heart; Muscular Diseases; Mutant Strains Mice; Mutation; Myocardial; Myocardium; Myocytes; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Natural regeneration; Nucleus; Organ; P53; Pathologic; Pathway interactions; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Point Mutation; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Potentiation; Predisposition; Preservation, Biologic; Preservation, Biological; Principal Investigator; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Family; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proto-Oncogene Protein c-kit; Publishing; Receptor Protein; Receptor, Apo E; Receptor, Apolipoprotein E; Regeneration; Rejuvenation; Research Personnel; Researchers; Resistance; Role; SCF Receptor; Scheme; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Stem Cell Factor Receptor; Stem cells; Stimulus; Structural Protein; Subcellular Process; Surface; Susceptibility; TP53; TP53 gene; TRP53; Telomerase; Testing; Tissue Growth; Tissues; Tumor Protein p53 Gene; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uvomorulin; Ventricular; Ventricular Dysfunction; Wild Type Mouse; Work; Youth; Youth 10-21; age dependent; age related; alpha-2-Macroglobulin Receptor; alpha2-Macroglobulin Signaling Receptor; aminoacid; balance; balance function; base; biological signal transduction; c kit; c-kit Protein; c-kit Receptor; cardiac failure; cardiac muscle; cell growth; disease causation; disease etiology; disease/disorder etiology; disorder etiology; gene product; genome mutation; heart muscle; improved; interventional strategy; juvenile animal; kit Proto-Oncogene Protein; life span; lifespan; liver cell adhesion molecule; membrane structure; migration; model organism; mouse model; mouse mutant; muscular disorder; necrocytosis; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; p145(c-kit); p145c-kit; pathophysiology; pathway; preservation; primitive cell; programs; receptor; regenerate; release factor; resistant; response; self-renewal; senescence; senescent; social role; stem cell niche; transcription factor; young animal",Aging and Homeostasis of Cardiac Stem Cell Niches,,26107,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,5,337965,
7794913,R01,AG,5,,02/01/2010,01/31/2011,,5R01AG026607-05,,NIA:360672;,2010,NATIONAL INSTITUTE ON AGING,,OKLAHOMA CITY,UNITED STATES,OTHER HEALTH PROFESSIONS,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"SONNTAG, WILLIAM EDMUND;",1871245;,5R01AG026607,03/01/2007,01/31/2012,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2 Dimensional Gel Electrophoresis; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-dimensional; 21+ years old; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5HT; Acetylcholine; Adult; Age; Aging; Aminalon; Aminalone; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Area; Atrophic; Atrophy; BDNF; Behavioral; Blood Coagulation Factor I; Blood Coagulation Factor IV; Blood Coagulation Factor One; Blood Factor One; Brain; Brain region; Brain-Derived Neurotrophic Factor; Butanoic acid, 4-amino-; Ca++ element; Calcium; Causality; Coagulation Factor I; Coagulation Factor IV; Coagulation Factor One; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Cornu Ammonis; Dendrites; Disturbance in cognition; Doctor of Philosophy; Dopamine; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Encephalon; Encephalons; Enteramine; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Etiology; Exercise; Exercise, Physical; Expression Profiling; Expression Signature; Factor I; Factor IV; Factor One; Fibrinogen; GABA; GHN; GHRH; GRH; Gene Proteins; Generalized Growth; Growth; Growth Hormone; Growth Hormone 1; Growth Hormone-Releasing Factor; Growth Hormone-Releasing Hormone; Healthcare Systems; Hippocampus; Hippocampus (Brain); Hippophaine; Human Pancreatic Growth Hormone-Releasing Factor; Human, Adult; Hydroxytyramine; IGF-1; IGF-I; IGF-I-SmC; IGF1; Impaired cognition; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intervention; Intervention Strategies; Investigation; Investigators; Laboratories; Learning; Length of Life; Levarterenol; Levonorepinephrine; Long-Term Potentiation; Longevity; MGC34632; Maintenance; Maintenances; Mass Spectrum; Mass Spectrum Analysis; Medical; Memory; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Morphology; Nerve Transmitter Substances; Nervous; Nervous System, Brain; Neuromediator Receptors; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Noradrenaline; Norepinephrine; P38 Membrane Protein, Synaptic Vesicle; Pathologic Processes; Pathological Processes; Pattern; Performance; Ph.D.; PhD; Photometry/Spectrum Analysis, Mass; Physiologic; Physiologic pulse; Physiological; Pituitary Growth Hormone; Prefrontal Cortex; Process; Production; Protein Gene Products; Protein P38, Synaptic Vesicle; Proteins; Proteome; Proteomics; Pulse; QOL; Quality of life; Receptors, Neurohumor; Regulatory Protein; Research Personnel; Researchers; STH; Senescence; Serotonin; Societies; Somatocrinin; Somatoliberin; Somatomedin C; Somatotropin; Somatotropin-Releasing Hormone; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Synapses; Synaptic; Synaptophysin; Systems, Health Care; Techniques; Tissue Growth; adult animal; adult human (21+); age dependent; age effect; age related; aged; aging brain; aging effect; base; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; d-Numb; decline in function; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; frontal cortex; frontal lobe; functional decline; gamma-Aminobutyric Acid; gel electrophoresis; gene product; genetic regulatory protein; glucose metabolism; hGHN; hippocampal; improved; intervention effect; interventional strategy; life span; lifespan; man; man's; mature animal; mid life; mid-life; middle age; middle aged; midlife; model organism; molecuar profile; molecular signature; neural; neuron cell death; neuron loss; neuronal cell death; neuronal loss; normal aging; novel; numb protein; ontogeny; protein expression; regulatory gene product; relating to nervous system; response; senescent; somatotropic hormone; therapeutic target; two-dimensional",Cognitive Decline & Protein Expression Profiles in Aging,,26607,LAM,Neurobiology of Learning and Memory Study Section,,5,360672,
7796799,R01,AG,5,,02/01/2010,11/30/2010,,5R01AG027628-05,,NIA:327342;,2010,NATIONAL INSTITUTE ON AGING,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"ZHENG, FENG ;",7130218;,5R01AG027628,12/15/2005,11/30/2010,"Acute; Age; Aging; Anemia; Apoptosis; Apoptosis Pathway; Apoptotic; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood Pressure, High; Blood Serum; C-reactive protein; CD120b; Cachectin; Cachectin Receptors; Cachectin-Tumor Necrosis Factor; Cardiovascular Diseases; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Change of Life, Female; Chronic; Chronic Kidney Failure; Chronic Renal Disease; Data; Development; Diabetes Mellitus; Differentiation Factor, B-Cell; Disease; Disorder; Female; HPGF; HTRPY; Hepatocyte-Stimulating Factor; Hybridoma Growth Factor; Hypertension; Hypertrophy; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Immunoglobulin Enhancer-Binding Protein; Individual; Inflammation; Inflammatory; Injury; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Investigators; Kidney; Kidney Diseases; Kidney Failure, Chronic; Knockout Mice; Lesion; MGI-2; Mammals, Mice; Mediating; Menopause; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Murine; Mus; Myeloid Differentiation-Inducing Protein; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nephropathy; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; P75TNFR; Pathway interactions; Persons; Plasmacytoma Growth Factor; Play; Population; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Process; Programs (PT); Programs [Publication Type]; Proteins; Proteins, specific or class, C-reactive; Receptor Protein; Renal Disease; Renal Failure, Chronic; Renal function; Research Personnel; Researchers; Resolution; Role; Scheme; Sclerosis; Senescence; Serum; Signal Transduction; Signal Transduction Systems; Signaling; TBPII; TNF; TNF (unspecified); TNF Alpha; TNF Receptor Family Protein; TNF Receptor Ligands; TNF Receptor Superfamily; TNF Receptors; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-R-II; TNF-R75; TNF-alpha; TNFA; TNFBR; TNFR; TNFR2; TNFR80; TNFRSF1B; TNFRSF1B gene; TNFSF2 protein, human; Testing; Transcription Factor NF-kB; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Tumor Necrosis Factors; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Woman; age dependent; age related; base; biological signal transduction; cardiovascular disorder; chronic kidney disease; cytokine; diabetes; disease/disorder; frailty; gene product; glomerular sclerosis; glomerulosclerosis; human TNF protein; hyperpiesia; hyperpiesis; hypertensive disease; improved; interferon beta 2; kappa B Enhancer Binding Protein; kidney disorder; kidney function; menopausal; mesangial cell; nuclear factor kappa beta; overexpression; pathway; post-menopausal; postmenopausal; programs; receptor; renal; renal disorder; response; senescent; social role; tumor; tumor necrosis factor (unspecified); tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",TNF-alpha Underlies Glomerular Aging in B6 Females,,27628,PBKD,Pathobiology of Kidney Disease Study Section,,5,327342,
7755401,R01,AG,5,,02/01/2010,12/31/2010,PA-07-070,5R01AG030425-02,,NIA:389019;,2010,NATIONAL INSTITUTE ON AGING,,BIRMINGHAM,UNITED STATES,SOCIAL SCIENCES,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"COTTEN, SHELIA R;",8638581;,5R01AG030425,01/15/2009,12/31/2013,"Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Active Follow-up; Age; Aged 65 and Over; Aging Process; Aging-Related Process; Alabama; American; Anxiety; Area; Assisted Living Facilities; Attention; Availability of Health Services; Awareness; Awarenesses; Beds; Capital; Care, Health; Caring; Characteristics; Cognitive; Communication; Computers; Control Groups; Controlled Study; Data Sources; Depression; Diagnosis; Disadvantaged; Disease; Disorder; Drugs; Education for Intervention; Educational Intervention; Educational Mainstreaming; Educational process of instructing; Elderly; Elderly depression; Elderly, over 65; Elements; Environment; Experimental Designs; Foundations; Goals; Happiness; Happinesses; Health; Health Informatics; Health Services Accessibility; Healthcare; Healthy People 2010; Home; Home environment; Impairment; Incentives; Individual; Inequality; Information Technology; Instruction Intervention; Internet; Intervention; Intervention Strategies; Intervention Studies; Investigators; Laboratory Study; Lead; Life; Light; Link; Living Wills; Loneliness; Long-Term Care; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Measures; Mediating; Mediation; Medical Sociology; Medication; Medicine; Mental Depression; Mental Health; Mental Hygiene; Methods; Methods and Techniques; Methods, Other; Negotiating; Negotiation; Nurses; Outcome; Pb element; Perception; Personnel, Nursing; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Population; Psychological Health; Psychology; Public Health; Public Health Informatics; QOL; Quality of life; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Design; Research Personnel; Research Resources; Researchers; Resources; Retirement; Risk; Sampling; Science of Medicine; Science of Statistics; Social Interaction; Social Network; Social isolation; Social support; Sociology of Medicine; Sociology, Medical; Sources, Data; Statistics; Stress; Students; Study Type; Survey Instrument; Surveys; System; System, LOINC Axis 4; Teaching; Techniques; Technology; Testing; Time; Training; Training Intervention; Trust; Variant; Variation; WWW; Work; access to services; access to treatment; adult youth; advanced age; age dependent; age related; assisted living; assistive living; assistive living facilities; availability of services; base; consumer informatics; design; designing; disease/disorder; drug/agent; elders; experience; extended care; follow up assessment; follow-up; geriatric; geriatric depression; graduate student; group intervention; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; heavy metal Pb; heavy metal lead; incentive; inducement; innovate; innovation; innovative; instructional intervention; intervention effect; interventional strategy; late life; late life depression; later life; loved ones; meetings; middle school; multidisciplinary; older adult; older person; physical conditioning; physical separation; positive attitude; post intervention; preference; public health medicine (field); public health relevance; randomized controlled study; rapid growth; recruit; senior citizen; skills; social; social capital; social support network; statistics; stem; study design; theories; web; world wide web; young adult",Using ICTs to Enhance Quality of Life Among Older Adults: An Intervention Study," Using ICTs to Enhance Quality of Life Among Older Adults: An Intervention Study Project Narrative The proposed research examines whether an Internet based training intervention can enhance social capital and quality of life among residents of assisted living facilities. As both the percentage of older adults in the population and the percentage of individuals entering assisted living increases, better understanding of the ways to enhance quality of life among these individuals is needed. This project is relevant to public health in that the focus is to enhance the health of a significant segment of the older adult population, it examines a variety of aspects of quality of life, and it is situated within the assisted living environment (an area that is expected to continue to grow in coming years).",30425,SPIP,"Social Psychology, Personality and Interpersonal Processes Study Section",,2,389019,
7755403,R01,AG,5,,02/01/2010,12/31/2010,PA-07-070,5R01AG030575-02,,NIA:1736782;,2010,NATIONAL INSTITUTE ON AGING,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"QUAGLIARELLO, VINCENT JAMES;",2185801;,5R01AG030575,01/15/2009,12/31/2013,"2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-; Adherence; Adherence (attribute); Age; Area; Chlorhexidine; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Unspecified; Control Groups; Data; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Deglutition; Dental Hygiene; Dentures; Effectiveness; Effectiveness of Interventions; Ensure; Futility; Geriatric Nursing; Gerontological Nursing; Human Resources; Intervention; Intervention Strategies; Long-Term Care Nursing; Lower Respiratory Tract Infection; Manpower; Manuals; Monitor; Nursing Home Nursing; Nursing Homes; Nursing of the Elderly; Oral; Oral Hygiene; Participant; Pilot Projects; Pneumonia; Pneumonitis; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Pulmonary Inflammation; Quality, Data; Randomized; Randomized Controlled Trials; Recurrence; Recurrent; Risk Factors; Safety; Safety Monitoring Boards; Sample Size; Swallowing; Testing; Time; Tooth; Tooth structure; Toothbrushing; Topical Antibiotic; Vulnerable Populations; base; clinical investigation; cohort; design; designing; effect of intervention; effective intervention; experience; feeding; interventional strategy; modifiable risk; nursing home; personnel; pilot study; primary outcome; programs; public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; teeth; tooth brushes; tooth brushing; toothbrush; treatment as usual",A Randomized Controlled Trial to Reduce Pneumonia in Nursing Home Residents," PROJECT NARRATIVE  The primary aim of this proposal is to conduct a clinical trial among elderly nursing home residents to determine whether an intervention is effective at reducing the rate of pneumonia. The intervention will consist of a combination of three components: 1) manual brushing of the gums, teeth and/or dentures twice a day; 2) oral rinsing with a topical antibiotic (i.e., chlorhexidine) twice a day; and 3) ensuring that residents are in an upright sitting position during feeding. This trial holds great promise in identifying a simple and effective intervention to reduce pneumonia in this vulnerable population of citizens.",30575,ASG,Aging Systems and Geriatrics Study Section,,2,1736782,
7751885,R01,AG,5,,02/01/2010,12/31/2010,PA-07-070,5R01AG031184-02,,NIA:283010;,2010,NATIONAL INSTITUTE ON AGING,,MISSOULA,UNITED STATES,OTHER HEALTH PROFESSIONS,00,010379790,US,MT,598124104,UNIVERSITY OF MONTANA,"CARDOZO-PELAEZ, FERNANDO ;",7263184;,5R01AG031184,01/01/2009,12/31/2012,"2'-deoxy-8-hydroxyguanosine; 8-OH-dG; 8-hydroxy-2'-deoxyguanosine; 8-hydroxydeoxyguanosine; 8-oxodGuo; Address; Affect; Age; Age of Onset; Aging; Agreement; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Apoptosis; Apoptosis Pathway; Brain; Brain region; Cell Death, Programmed; Cells; Cessation of life; DA Neuron; DNA; DNA Alteration; DNA Damage; DNA Injury; DNA Repair Enzymes; DNA mutation; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Development; Disease; Disorder; Dopamine neuron; Encephalon; Encephalons; Enzymes; Exhibits; Free Radicals; Gene Alteration; Gene Mutation; Genes; Genetic; Genetic Models; Genetic mutation; Glean; Idiopathic Parkinson Disease; Knock-out; Knockout; Lead; Lewy Body Parkinson Disease; Lipids; Mammals, Mice; Measurement; Mice; Modeling; Models, Genetic; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological; Neurological Disorders; Neuron Degeneration; Neurons; Neurotoxins; Nuclear; Oxidation-Reduction; Oxidative Stress; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathologic Processes; Pathological Processes; Pathology; Pathway interactions; Patients; Pb element; Play; Population; Predisposition; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Proteins; Redox; Role; Senescence; Sequence Alteration; Substantia Nigra; Substantia nigra structure; Susceptibility; System; System, LOINC Axis 4; Testing; Therapeutic; Toxin; Transgenic Organisms; Wild Type Mouse; age dependent; age related; base; dementia of the Alzheimer type; design; designing; disease/disorder; dopaminergic neuron; gene product; genetic manipulation; heavy metal Pb; heavy metal lead; mouse model; mutant; nervous system disorder; neural degeneration; neurodegeneration; neurodegenerative illness; neurological disease; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuroprotection; neurotoxicant; nigrostriatal dopaminergic pathway; nigrostriatal pathway; nigrostriatal system; novel; oxidation reduction reaction; oxidative DNA damage; oxidative damage; pathway; prevent; preventing; primary degenerative dementia; public health relevance; repair; repaired; response; senescent; senile dementia of the Alzheimer type; social role; synuclein; transgenic",Oxidative damage to DNA: implications for neurodegeneration in aging," Project Narrative The development of most neurodegnerative diseases is associated with increased oxidative damage to DNA; however, the mechanisms associated with oxidative damage-driven neuronal loss in neurodegenerative diseases is poorly understood. This proposal is designed to address such mechanisms and to use this information to design therapeutic approaches that target oxidative damage to DNA aimed to treat or prevent deisease.",31184,NOMD,Neural Oxidative Metabolism and Death Study Section,,2,283010,
7751256,R01,AG,5,,01/01/2010,12/31/2010,PA-07-070,5R01AG032320-02,,NIA:307469;,2010,NATIONAL INSTITUTE ON AGING,,MILWAUKEE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"GERGES, NASHAAT Z;",9066678;,5R01AG032320,01/01/2009,12/31/2013,"Address; Affinity; Age; Aging; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Ca++ element; CaM KII; CaM PK II; CaM kinase II; CaMKII; Calcineurin; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Coagulation Factor IV; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cornu Ammonis; DNA Molecular Biology; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dendrites; Dendritic Spines; Disturbance in cognition; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Electrophysiology; Electrophysiology (science); Equilibrium; Factor IV; Figs; Figs - dietary; Functional disorder; Gene Products, RNA; Genetic; Goals; Head and Neck, Thyroid; Hippocampus; Hippocampus (Brain); Hypothyroidism; Imaging Procedures; Imaging Techniques; Impaired cognition; Knock-out; Knockout; Knockout Mice; Learning; Little's Disease; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Memory; Memory Deficit; Memory impairment; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Biology; Molecular Interaction; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology / Electrophysiology; Null Mouse; PP2B; Performance; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiopathology; Play; Primary Senile Degenerative Dementia; Protein Binding; Protein Phosphatase-2B; Proteins; RC3 protein; RNA; RNA, Non-Polyadenylated; Receptor Activation; Receptors, N-Methylaspartate; Regulation; Replacement Therapy; Ribonucleic Acid; Role; Schizophrenia; Schizophrenic Disorders; Senescence; Spastic Diplegia; Spastic Diplegias; Spinal Column; Spine; Stress; Synapses; Synaptic; Synaptic plasticity; Technics, Imaging; Testing; Thyroid; Thyroid Gland; Vertebral column; Vitamin A; backbone; balance; balance function; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cerebral spastic infantile paralysis; cognitive dysfunction; cognitive loss; cognitively impaired; dementia of the Alzheimer type; dementia praecox; dendrite spine; experiment; experimental research; experimental study; gene product; hippocampal; long term depression; nervous system disorder; neurogranin; neurological disease; neuronal; p17 protein kinase C substrate; pathophysiology; postsynaptic; primary degenerative dementia; public health relevance; research study; retinol; schizophrenic; senescent; senile dementia of the Alzheimer type; social role; success; synapse function; synaptic function",Role of Neurogranin in Hippocampal Synaptic Plasticity," PROJECT NARRATIVE: Neurogranin has been implicated in several neurological disorders, such as Alzheimer's disease, schizophrenia, hypothyroidism, stress and aging. Neurogranin plays a significant role in synaptic plasticity and memory, and its down regulation may result in cognitive dysfunction. We hypothesize that neurogranin controls the synaptic plasticity balance, through its regulation of calmodulin availability. Thus we propose to study the role of neurogranin in synaptic plasticity, which, we believe, will enable us to better understand the molecular alterations that may contribute to the pathophysiology of many neurological diseases.",32320,LAM,Neurobiology of Learning and Memory Study Section,,2,307469,
7768500,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI009644-41,,NIAID:693008;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"NIKAIDO, HIROSHI ;",1906053;,5R01AI009644,03/01/1976,02/28/2011,"Address; Aminoglycosides; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Area; Assay; Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Cell Membrane Permeability; Cell membrane; Cell surface; Cells; Charge; Chemistry, Biological; Clinical; Complex; Cytoplasmic Membrane; Development; Drug Resistance, Multiple; Drug Resistant, Multiple; Drugs; E coli; Escherichia coli; Family; Future; Genetic Alteration; Genetic Change; Genetic defect; Gram-Negative Bacteria; Health; Human; Human, General; LPS; Laboratories; Lead; Lipopolysaccharides; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Medication; Membrane; Miscellaneous Antibiotic; Molecular; Molecular Genetic; Molecular Genetics; Multi-Drug Resistance; Multidrug Resistance; Mutation; Organism; Pathway interactions; Pb element; Penetration; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphatides; Phospholipids; Plasma Membrane; Play; Prevalence; Prevention; Process; Property; Property, LOINC Axis 2; Pump; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Source; Stress; Structure; Substrate Specificity; Time; Work; anti-microbial; anti-microbial agent; anti-microbial drug; antimicrobial; antimicrobial agent; antimicrobial drug; cell envelope; clinical relevance; clinically relevant; drug/agent; efflux pump; genome mutation; heavy metal Pb; heavy metal lead; living system; member; membrane permeability; membrane structure; multi-drug resistant; multidrug resistant; novel; pathogenic bacteria; pathway; plasmalemma; pore forming protein; porin; prevent; preventing; prototype; resistant; resistant strain; small molecule; social role; solute",Biochemistry of Bacterial Cell Membranes,,9644,ZRG1,Special Emphasis Panel,,41,693008,
7759587,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI015429-30,,NIAID:337135;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,ZOOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"STRETTON, ANTONY O.;",1903101;,5R01AI015429,02/15/2006,01/31/2011,"Affect; Affinity; Antibodies; Area; Ascaris; Ascaris suum; Basic Research; Basic Science; Behavior; Biochemical; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Connector Neuron; DNA Molecular Biology; Dorsal; Drug resistance; Drugs; Electromagnetic, Laser; Family; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Generations; Genetic; Genetics, in situ Hybridization; Grant; HPLC; High Pressure Liquid Chromatography; In Situ Hybridization; In element; Indium; Individual; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Lasers; Locomotion; Locomotor Activity; MALDI-TOF Mass Spectrometry; Mass Spectrum; Mass Spectrum Analysis; Matrix-Assisted Laser Desorption Ionization Time-of-Flight MS; Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry; Mediating; Medication; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Biology; Morphology; Motor; Motor Activity; Motor Cell; Motor Neurons; Movement; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tension; Muscle Tissue; Muscular Tension; Myocytes; Myxoid cyst; NRVS-SYS; Nematoda; Nematodes; Nerve; Nerve Cells; Nerve Tissue; Nerve Unit; Nervous; Nervous System; Nervous Tissue; Nervous system structure; Neural Cell; Neural Ganglion; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neuropeptide Gene; Neuropeptides; Palsy; Paralysed; Parasitic nematode; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Play; Plegia; Position; Positioning Attribute; Process; Radiation, Laser; Relaxation; Reporting; Research; Role; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; System; System, LOINC Axis 4; Techniques; Testing; Time; Tissues; Transcript; Work; aminoacid sequence of peptide; aminoacid sequence of protein; base; biological signal transduction; body movement; cell body (neuron); cellular targeting; designer antibody; drug resistant; drug/agent; experiment; experimental research; experimental study; falls; immunocytochemistry; in situ Hybridization Staining Method; in vivo; interdisciplinary approach; molecular mass; motoneuron; neural; neural cell body; neuromotor system; neuromuscular system; neuronal; neuronal cell body; novel; paralysis; paralytic; peptide sequence; protein aminoacid sequence; relating to nervous system; research study; resistance to Drug; resistant to Drug; roundworm; social role; soma",Structure and Function of Ascaris Neuropeptides,,15429,PTHE,Pathogenic Eukaryotes Study Section,,30,337135,
7763820,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI015539-29,,NIAID:343262;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GAINESVILLE,UNITED STATES,BIOCHEMISTRY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"FLANEGAN, JAMES BERT;",1950941;,5R01AI015539,09/01/1979,01/31/2011,"Acute Nasopharyngitis; Assay; Atomic Force Microscope; Atomic Force Microscopy; Bioassay; Biochemical; Biologic Assays; Biological Assay; Breakbone Fever Virus; Cells; Clinical; Common Cold; Complex; Conserved Sequence; DNA Molecular Biology; Dengue Virus; Disease; Disorder; Egypt 101 virus; Encephalitis; Epidemic Acute Poliomyelitis; Family Picornaviridae; Force Microscopy; Gene Products, RNA; Genomics; Grant; HCV; HeLa; Hela Cells; Hepatitis; Hepatitis C virus; Hepatitus C; Host Factor; Host Factor Protein; Human; Human poliovirus; Human, General; Inflammation, Brain; Integration Host Factors; Man (Taxonomy); Man, Modern; Meningitis; Microscopy, Atomic Force; Modeling; Molecular; Molecular Biology; Myocarditis; Palsy; Paralysed; Patients; Picornaviridae; Picornaviruses; Plegia; Polio; Polio Virus; Poliomyelitis; Poliomyelitis, Acute; Poliovirus; Polioviruses; Poly(A) Tail; Post-Polio Syndrome; Post-Poliomyelitis Muscular Atrophy; Post-Poliomyelitis Syndrome; Postpoliomyelitis Muscular Atrophy; Postpoliomyelitis Syndrome; Proteins; RNA; RNA Sequences; RNA Stability; RNA Viruses; RNA chemical synthesis; RNA replication; RNA synthesis; RNA, Non-Polyadenylated; RNA, Viral; RNA-Protein Interaction; Reaction; Ribonucleic Acid; Role; SARS Virus; SARS coronavirus; SARS-Associated Coronavirus; SARS-CoV; SARS-Related Coronavirus; Scanning Force Microscopy; Sequences, RNA; Severe Acute Respiratory Syndrome Virus; Structure; Testing; Translation Initiation; Translations; Urbani SARS-Associated Coronavirus; Viral; Virus; Viruses, General; WNV; West Nile; West Nile virus; Work; base; disease/disorder; experiment; experimental research; experimental study; gene product; in vitro Assay; member; paralysis; paralytic; pathogen; poliomyelitis virus; postpolio syndrome; protein protein interaction; reconstitute; reconstitution; research study; social role; viral RNA; virus RNA",Molecular Biology of Poliovirus RNA Replication,,15539,VIRB,Virology - B Study Section,,29,343262,
7777794,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI018697-30,,NIAID:247348;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RICHMOND,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"CONRAD, DANIEL H;",1884823;,5R01AI018697,05/01/1989,02/28/2013,"3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-; Address; Affect; Affinity; Allergic; Allergic Disease; Allergic rhinitis; Allergic rhinitis due to allergen; Allergic rhinosinusitis; Alum Adjuvant; Animals; Antibodies; Antimorphic mutation; Area; Asthma; Atopic Allergy; Atopic rhinitis; B blood cells; B-Cells; B-Lymphocytes; Backcrossings; Binding; Binding (Molecular Function); Biological Models; Blood Serum; Bronchial Asthma; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD 23 Antigens; CD23 Antigens; Cell Communication and Signaling; Cell Signaling; Cell surface; Cleaved cell; Collaborations; Common Rat Strains; Cytokines, Chemotactic; Data; Digenic Acid; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Eosinophilia; Esteroproteases; Exhibits; Funding; Genes; Helminths; Homologous Chemotactic Cytokines; Human; Human, General; IDEC-152 Monoclonal Antibody; IgE; IgE Receptors; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin E; Immunoglobulin E Receptor; In Vitro; Injection of therapeutic agent; Injections; Intercrines; Intracellular Communication and Signaling; Kainic Acid; Laboratories; Lectin; Low affinity IgE receptor; Lymphocyte; Lymphocyte Function; Lymphocytic; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Mice, Transgenic; Moab, Clinical Treatment; Model System; Modeling; Models, Biologic; Molecular Interaction; Monoclonal Antibodies; Mouse Strains; Murine; Mus; Natural Immunity; Patients; Peptidases; Peptide Hydrolases; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Play; Preparation; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; Protocol; Protocols documentation; Publishing; RNA, Messenger; RNA, Small Interfering; Rat; Rattus; Reagent; Receptor Protein; Receptors, IgE; Regulation; Relative; Relative (related person); Rhinitis allergic atopic; Role; SIS cytokines; Serum; Severities; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small Interfering RNA; Structure; Surface; System; System, LOINC Axis 4; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Wild Type Mouse; Work; Worms, Parasitic; alum; aluminum sulfate; anti-CD23; anti-IgE; anti-IgEid; atopy; biological signal transduction; cell type; chemoattractant cytokine; chemokine; cleaved; cytokine; disease control; disease severity; disease/disorder; disorder control; epsilon Fc Receptors; epsilon RII, Fc; extracellular; improved; in vivo; inhibitor; inhibitor/antagonist; interest; lymph cell; mRNA; metalloproteinase (general); mouse model; overexpression; p5E8; programs; receptor; response; role model; siRNA; social role; transcription factor; transgenic",Structure and Function of the Lymphocyte Fce Receptor,,18697,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,30,247348,
7760526,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI018757-28,,NIAID:408375;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,PATHOLOGY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"THORLEY-LAWSON, DAVID A;",1865251;,5R01AI018757,09/01/1981,01/31/2013,"ATGN; Address; Affinity; Animal Welfare; Antibodies; Antigens; Autoantigens; Autoimmune Diseases; Autologous Antigens; B blood cells; B-Cells; B-Lymphocytes; Bibliography; Biology; Burkitt Herpesvirus; Burkitt Lymphoma; Burkitt Lymphoma Virus; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CALLA; CD10; Carcinoma; Cell Communication and Signaling; Cell Signaling; Cells; Coon's Technic; Coon's Technique; Country; Cytofluorometry, Flow; E-B Virus; EB virus; EBV; EBV Infections; ELISA; Ecological impact; Environment; Environmental Impact; Enzyme-Linked Immunosorbent Assay; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus Infections; Equipment; Ethics Committees, Research; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescent Antibody Technic; Fluorescent Antibody Technique; Fluorescent Antinuclear Antibody Test; Genes, p53; Germinal Center; Germinoblastoma; Goals; HHV-4; Heart; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Human; Human Herpes Virus 4 Infections; Human Herpesvirus 4; Human Herpesvirus 4 Infections; Human, General; IACUC; IRBs; Immune Globulins; Immunity; Immunofluorescence Technic; Immunofluorescence Technique; Immunoglobulins; Immunoglobulins / Antibodies; Impact, Environmental; In Vitro; Individual; Infection; Infectious Mononucleosis Virus; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; LMP1; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphogranuloma, Malignant; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MME; MME gene; Man (Taxonomy); Man, Modern; Memory; Memory B Cell; Memory B-Lymphocyte; Microfluorometry, Flow; Modeling; Names; P53; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Proliferating; Proteins; RT-PCR; RTPCR; Reaction; Research; Research Ethics Committees; Research Resources; Resources; Reticulolymphosarcoma; Reverse Transcriptase Polymerase Chain Reaction; Role; SLE; SLE - Lupus Erythematosus, Systemic; Sarcoma, Germinoblastic; Self-Antigens; Signal Transduction; Signal Transduction Systems; Signaling; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Source; Structure of germinal center of lymph node; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; TP53; TP53 gene; TRP53; Testing; Tonsil; Tumor Protein p53 Gene; Vertebrate Animals; Vertebrates; abstracting; autoimmune disorder; autoreactive B cell; autoreactivity; base; biological signal transduction; c myc; c-myc Genes; chemokine receptor; disseminated lupus erythematosus; epithelial carcinoma; expiration; flow cytophotometry; fluorescent antibody; gene product; human herpesvirus 4 group; human subject; immunogen; in vivo; infected B cell; infected B lymphocyte; laser capture microdissection; lymphogranulomatosis; lymphogranulomatosis (malignant); programs; reverse transcriptase PCR; social role; systemic lupus erythematosis; tonsillar; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; vertebrata",Host Immunity to EBV Infection in Vitro and in VIvo,,18757,VIRB,Virology - B Study Section,,28,408375,
7777881,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI019769-25,,NIAID:376576;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,PATHOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"CHRISTENSEN, BRUCE MARTIN;",8064273;,5R01AI019769,04/01/1983,02/29/2012,"2-dimensional; Address; Affinity; Affinity Chromatography; Amino Acid Sequence; Anabolism; Animals; Arthropoda; Arthropods; Asians; Bacteria; Bancroftian Elephantiasis; Bio-Informatics; Biochemical; Biochemical Pathway; Biochemistry; Bioinformatics; Biomedical Research; Blood Plasma; Brugia malayi; Brugia pahangi; Cell Communication and Signaling; Cell Signaling; Chemistry, Biological; Chorion; Chromatography, Affinity; Communities; Competence; Complement; Complement Proteins; Complex; Computational Biology; Computer Simulation; Computerized Models; Computing Methodologies; Culicidae; Data; Dependence; Deposit; Deposition; Detection; Dirofilaria immitis; Dog Heartworm; ESTs; Electromagnetic, Laser; Encapsulated; Evolution; Expressed Sequence Tags; Expression Profiling; Expression Signature; Filarial Elephantiases; Filariasis; Filarioidea Infections; Fluorescence; Future; Gene Action Regulation; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Gene Proteins; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genetic; Genetic Transcription; Glucans; Glucose Polymer; Goals; Health; Hemolymph; Human; Human Development; Human, General; Immune; Immune response; Immune system; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Insect Proteins; Insecta; Insects; Intracellular Communication and Signaling; Invertebrata; Invertebrates; Invertebrates, General; Invertebrates, Insects; Investigation; Isotopically-Coded Affinity Tagging; Killings; Knock-out; Knockout; LC/MS; Laboratories; Lasers; Life Cycle; Life Cycle Stages; Link; Literature; Lymphatic Filariasis; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Melanins; Metabolic Networks; Methods; Methods and Techniques; Methods, Other; Midgut; Modeling; Models, Computer; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Mosquito Control; Mosquito-borne disease; Mosquito-borne infectious disease; Mosquitoes; Natural Immunity; Natural Resistance; Nature; Nematoda; Nematodes; Nucleotides; Oligo; Oligonucleotides; Parasites; Pathway interactions; Pattern; Pattern Recognition; Pattern Recognition/Display/Analysis; Phase; Phenotype; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiology; Plasma; Play; Polyglucoses; Population; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-Translational Modifications; Post-Translational Protein Processing; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Posttranslational Modifications; Prevention; Production; Protein Gene Products; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Structure, Primary; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation, Laser; Reaction; Regulation; Relative; Relative (related person); Research; Reticuloendothelial System, Serum, Plasma; Risk; Role; Sampling; Sequence-Specific Posttranscriptional Gene Silencing; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Skin tanning; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; System; System, LOINC Axis 4; Tagging, Isotope-Coded Affinity; Tanning; Tannings; Targetings, Gene; Techniques; Testing; Time; Transcript; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Translations; Wound Healing; Wound Repair; abstracting; affinity purification; base; biological signal transduction; biosynthesis; body system, allergic/immunologic; cDNA Library; comparative; computational methodology; computational methods; computational modeling; computational models; computational simulation; computer based models; computer methods; computerized modeling; computerized simulation; curdlan; defense response; disease control; disorder control; egg; enzyme substrate; experiment; experimental research; experimental study; gel electrophoresis; gene expression signature; gene product; heart worm; holistic approach; host response; immunoresponse; in silico; interest; life course; liquid chromatography mass spectrometry; molecuar profile; molecular mass; molecular signature; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; oriental; pathogen; pathway; pro-phenoloxidase; prophenol oxidase; prophenoloxidase; protein complex; protein expression; protein sequence; research study; resistance mechanism; resistant mechanism; response; roundworm; social role; tandem mass spectrometry; tissue repair; tool; transcriptome; two-dimensional; vector; vector mosquito; virtual simulation",Immune Response of Mosquitoes to Filarial Worms,,19769,VB,Vector Biology Study Section,,25,376576,
7771691,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI020211-26,,NIAID:383625;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"MCCORMICK, ANITA LOUISE;",1944233;,5R01AI020211,03/01/1984,01/31/2014,"0-11 years old; ATP-protein phosphotransferase; Acute; Address; Affect; Animals; Antiviral Agents; Antiviral Drugs; Antivirals; Apoptosis; Apoptosis Inhibitor; Apoptosis Inhibitor Gene; Apoptosis Pathway; Apoptotic; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; CMV; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Death; Cell Death Induction; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cell-Death Protease; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chemicals; Child; Child Youth; Children (0-21); Chronic Disease; Chronic Illness; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; DISSEC; DNA; DNA Replication; DNA Synthesis; DNA biosynthesis; Death; Deoxyribonucleic Acid; Disease; Disorder; Dissection; Equilibrium; Evaluation; Event; Exhibits; Family; Fibroblasts; GADD45; Gene Expression; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; HCMV; Herpesvirus 1 (beta), Murid; Homolog; Homologous Gene; Homologue; Human; Human, Child; Human, General; ICE-like protease; IFN; Immune; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Inclusion Disease; Individual; Infection; Inflammatory; Interferon Activation; Interferons; Intracellular Communication and Signaling; Investigation; L-Serine; Lead; Length; Link; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Mutant Strains; Mitochondria; Mouse Cytomegalovirus; Murid herpesvirus 1; Murine; Murine Cytomegalovirus; Mus; Mutant Strains Mice; Mutation; Outer Mitochondrial Membrane; Pathogenesis; Pathway interactions; Pb element; Phase; Phenotype; Phosphorylation; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Process; Programs (PT); Programs [Publication Type]; Protein Family; Protein Kinase; Protein Phosphorylation; Proteins; Publications; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Research; Role; Salivary Gland Virus Disease; Salivary Gland Viruses; Scientific Publication; Sequence-Specific Posttranscriptional Gene Silencing; Serine; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Subcellular Process; Suppressor Cells; Suppressor-Effector T-Lymphocytes; Susceptibility; T Suppressor Cell; T-Cells, Suppressor-Effector; T-Lymphocytes, Suppressor-Effector; Time; Tropism; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Gene Products; Viral Gene Proteins; Viral Pathogenesis; Viral Physiology; Viral Proteins; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Viruses, General; Work; attenuation; balance; balance function; base; biological signal transduction; caspase; cell behavior; cell type; cellular targeting; children; chronic disease/disorder; chronic disorder; clinical relevance; clinically relevant; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; cytolysin; cytomegalovirus group; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human cytomegalovirus; hydroxyalkyl protein kinase; immunosuppressed patient; inhibitor; inhibitor/antagonist; insight; lymphocyte pore-forming protein; mitochondrial; mouse mutant; mutant; necrocytosis; novel; pathogen; pathway; perforin; phosphorylase b kinase kinase; premature; prevent; preventing; programs; public health relevance; research study; response; sensor; social role; suppressor T lymphocyte; viral infection; virus infection; virus multiplication; virus protein; youngster",Cytomegalovirus DNA replication and inversion," Relevance Human cytomegalovirus (CMV) remains a major cause of congenital disease in children as well as a significant opportunistic pathogen in immunocompromised individuals, causing acute and chronic disease consequences despite the use of antiviral drugs. Virus-infected cells die in a proscribed way that relies on a novel host cell pathway triggered by a mitochondrial resident serine protease HtrA2/Omi and is controlled by the product of the viral UL37x1 gene, a powerful suppressor of cell death. This investigation will lead to a more complete understanding of the interplay of cellular and viral functions as determinants of cell fate.",20211,VIRA,Virology - A Study Section,,26,383625,
7760139,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI020566-27,,NIAID:558324;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"HOGLE, JAMES M;",1892937;,5R01AI020566,12/01/1983,01/31/2013,"Actins; Addendum; Address; Animal Welfare; Award; Back; Bibliography; Biochemical Genetics; Budgets; Cell membrane; Cell surface; Cells; Cellular Membrane; Cellular biology; Classification; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Computer Simulation; Computerized Models; Country; Coupled; Critiques; Cryo-electron Microscopy; Cryoelectron Microscopy; Crystallization; Crystallographies; Crystallography; Cytoplasm; Cytoplasmic Membrane; Dorsum; Ecological impact; Editorial Comment; Editorial Comment (PT); Electron Cryomicroscopy; Enterovirus; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Fluorescence Microscopy; Funding; Gene Products, RNA; Genetic, Biochemical; Genome; Goals; Grant; Human; Human Resources; Human poliovirus; Human, General; Hybrids; IACUC; IRBs; Image; Impact, Environmental; In Situ; In Vitro; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Label; Laboratories; Left; Life; Liposomal; Liposomes; Location; Man (Taxonomy); Man, Modern; Manpower; Mathematical Model Simulation; Mathematical Models and Simulations; Membrane; Membrane Fusion; Methods; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Models, Computer; Motion; Nature; Optical Tomography; Optics; Pathway interactions; Plasma Membrane; Polio Virus; Poliovirus; Polioviruses; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Published Comment; RNA; RNA, Non-Polyadenylated; RNA, Viral; Receptors, Virus; Relative; Relative (related person); Reports, Progress; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Rhinovirus; Ribonucleic Acid; Role; Sampling; Series; Simulation, Computer based; Structure; Systematics; TXT; Techniques; Text; Time; Tomography, Optical; Update; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral Receptor; Virus; Virus Receptors; Viruses, General; Work; abstracting; base; cell biology; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cost; cost effective; cryoEM; design; designing; electron tomography; expiration; high risk; human subject; imaging; in silico; insight; membrane structure; nano meter; nanometer; particle; pathogen; pathway; personnel; plasmalemma; poliomyelitis virus; programs; prototype; receptor binding; reconstruction; response; social role; vertebrata; viral RNA; virtual simulation; virus RNA",Poliovirus Cell Entry Pathways,,20566,VIRA,Virology - A Study Section,,27,558324,
7764762,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI022571-22,,NIAID:420750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"WELLER, PETER F;",1868217;,5R01AI022571,07/01/1985,01/31/2014,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; 1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; 1-Alkyl-2-acetyl-sn-glycerophosphocholine; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; 12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; 12-O-tetradecanoylphorbol-13-acetate; 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 2-(Acetyloxy)benzoic Acid; 5-Lipoxygenase; 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))-; A 23187; A23187; AGEPC; ATP-Binding Cassette, Sub-Family B Proteins; Abbreviations; Acetylsalicylic Acid; Acidophilic Leukocyte; Address; Adipocytes; Adipose Cell; Agonist; Allergic; Allergic Disease; Allergic inflammation; Antibiotic A23187; Arachidonate 5-Lipoxygenase; Arachidonate[{..}]oxygen 5-oxidoreductase; Arachidonic Acid 5-Lipoxygenase; Arachidonic Acid Cyclooxygenase; Arachidonic Acids; Aspergum; Aspirin; Asthma; Avidin; Basophilic Granulocyte; Basophilic Histiocyte; Basophilic Leukocyte; Basophils; Basophils, Tissue; Biotin; Blood (Leukemia); Blood Basophil; Blood Coagulation Factor IV; Blood Eosinophil; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Body Tissues; Bronchial Asthma; COX; Ca++ element; Calcium; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Communication and Signaling; Cell Signaling; Cells; Coagulation Factor IV; Common Rat Strains; Complex; Cyclo-Oxygenase; Cyclooxygenase; Cys-LT; Cytokine Receptors; Cytoplasmic Granules; Cytoplasmic Inclusion; Cytosolic Phospholipase A2; Cytosolic Phospholipase A2 Group IV; Cytosolic Phospholipase A2G4; Cytosolic Phospholipase A2IV; DIF; Dinoprostone; Disease; Disorder; Disseminated eosinophilic collagen disease; EC 2.7.2-; ERK MAP Kinases; Ecotrin; Eicosanoids; Empirin; Endoplasmic Reticulum; Entericin; Enzymes; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Ergastoplasm; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Extren; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Factor IV; Fat Cells; Fatty Acid Cyclo-Oxygenase; Glycerin; Glycerol; Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))-; HETE; Heterophil Granulocyte; Hydroperoxide Cyclase; Hydroxyeicosatetraenoic Acids; Hypereosinophilic Syndrome; IL-16; IL16; IL16 Protein; INFLM; IgE; Immunoglobulin Binding Factor; Immunoglobulin E; Immunoglobulin binding proteins; In Vitro; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interleukin-16; Intracellular Communication and Signaling; Investigation; Ionophores; LCF; LCF Factor; LPS; LTA4 Synthase; LTB4; LTC4; LTC4 synthase; Lecithinases; Leukemias, General; Leukocytes; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase; Leukotriene B-4; Leukotriene B4; Leukotriene C-4; Leukotriene C4; Leukotrienes; Linoleate-Oxygen Oxidoreductase; Linoleate[{..}]oxygen 13-oxidoreductase; Lipids; Lipocytes; Lipopolysaccharides; Lipoxidase; Lipoxygenase; Lymphocyte Chemoattractant Factor; MAP Kinase Kinases; MAP kinase; MAPK; MAPK Kinases; MAPKKs; Mammals, Rats; Marrow Basophil; Marrow Eosinophil; Marrow Mast Cell; Marrow Neutrophil; Marrow leukocyte; Mature Lipocyte; Mature fat cell; Measurin; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Messenger RNA; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Moab, Clinical Treatment; Modeling; Monoclonal Antibodies; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nuclear; Oleic Acids; Organelles; P-Glycoproteins; PAF; PAF-Acether; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase; PGH2 Synthetase; PKC; PLA(2)-IV; PLA2-IV; PMA; PMAS; Peptide Biosynthesis, Ribosomal; Phorbol Myristate Acetate; Phospholipase; Phospholipase A2G4; Phospholipase A2IV; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylcholine, Acetyl Glyceryl Ether; Platelet Activating Factor; Platelet-Activating Substance; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin H Synthase; Prostaglandin H2 Synthetase; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandins; Prostanoids; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase C; Protein Synthesis, Ribosomal; Proteins; Proteome; Proteomics; Public Health; RAFT-1 gene product; RAFT1 protein, human; RAPT1 protein, human; RNA, Messenger; Rapamycin Target Protein; Rat; Rattus; Receptor Protein; Receptors, Cytokine; Regulation; Renaissance; Research; Reticuloendothelial System, Leukocytes; Ribosomes; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; TNF; TNF A; TNF gene; TNFSF2; Tetradecanoylphorbol Acetate; Threonine/Tyrosine Protein Kinase; Tissues; Tumor Necrosis Factor Gene; Vitamin H; White Blood Cells; White Cell; base; biological signal transduction; cPLA2; carotene oxidase; coenzyme R; cysteinyl leukotriene receptor; cysteinyl-leukotriene; cytokine; disease/disorder; eosinocyte; eosinophil; extracellular; extracellular signal related kinase; gene product; granule; human FRAP1 protein; in vivo; interest; leukemia; leukotriene A4-glutathione S-leukotrienyltransferase; leukotriene C4 synthetase; leukotriene-C4 synthase; mRNA; mRNA Expression; mTOR; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); mast cell; mastocyte; membrane structure; neutrophil; novel; paracrine; phospholipase A2 IV; prIL-16; protein synthesis; public health medicine (field); public health relevance; rapamycin and FKBP12 target 1 protein, human; receptor; receptor expression; response; social role; white blood cell; white blood corpuscle",Cytoplasmic Lipid Bodies of Inflammatory Cells, Asthma and related disorders due to allergic inflammation are increasingly prevalent diseases. The research will help in understanding mechanisms of allergic inflammation that are responsible for making asthma and allergic diseases major public health problems.,22571,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,22,420750,
7755379,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI023859-23,,NIAID:381150;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,603503991,US,NY,10031,CITY COLLEGE OF NEW YORK,"GOYERT, SANNA M.;",1903091;,5R01AI023859,01/01/1989,01/31/2013,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Adhesion Molecule; Affect; Animal Welfare; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Area; Ascitic Fluid; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial Infections; Bacterial resistant; Bibliography; Biological Function; Biological Process; Biology; Blood; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Budgets; CAPS; CD14; CD14 Antigen; CD14 Monocyte Differentiation Antigen; CD14 gene; CD14 molecule; CD14 receptor; CSBP1; CSBP2; CSPB1; Capsules; Cell Adhesion Molecules; Cell surface; Clinical; Collaborations; Complex; Country; Cytokines, Chemotactic; DIF; DNA Sequence; Defect; Disease; Disorder; Dose; E coli; ELISA; EXIP; Ecological impact; Encapsulated; Endothelial Cells; Environment; Environmental Impact; Enzyme-Linked Immunosorbent Assay; Equipment; Escherichia coli; Ethics Committees, Research; Event; Exposure to; Extracellular Signal-Regulated Kinase Gene; Genes; Goals; Gram-Negative Bacteria; Grant; Greater sac of peritoneum; Health; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Human; Human, General; IACUC; IRBs; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunologic Receptors; Immunological Receptors; Impact, Environmental; Individual; Infection; Infiltration; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; International; Investigators; Killings; Knowledge; Lead; Legal patent; Life; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Microbe; Microorganisms, General; Miscellaneous Antibiotic; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mxi2; Myeloid Cell-Specific Leucine-Rich Glycoprotein; Myeloid Cells; Natural Immunity; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organ failure; Organism; Outcome; PI-3 Kinase; PI-3K; PI3-Kinase; PRKM14; PRKM15; Patents; Pathogenicity Factors; Pathway interactions; Patients; Pb element; Peritoneal Cavity; Peritoneal Effusion; Peritoneal Fluid; Persons; Phagocytosis; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; PtdIns 3-Kinase; Reagent; Receptor Protein; Receptor, LPS; Receptor, Lipoglycan; Receptors, Immunologic; Receptors, Lipopolysaccharide; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resistance; Resistance to infection; Resources; Reticuloendothelial System, Blood; Role; SAPK2A; SIS cytokines; Scientist; Sepsis; Sepsis Syndrome; Septic Shock; Serum; Signal Pathway; Signaling Molecule; Site; Study Type; Systemic Inflammatory Response Syndrome; TIL4; TLR2; TLR2 receptor; TLR4; TLR4 gene; TNF; TNF A; TNF gene; TNFSF2; TOLL; Technology; Testing; Time; Toll-Like Receptor 2; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; Translational Research; Translational Research Enterprise; Translational Science; Tumor Necrosis Factor Gene; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Vertebrate Animals; Vertebrates; Virulence Factors; Work; abstracting; bacterial disease; bacterial resistance; base; bloodstream infection; capsule (pharmacologic); cell adhesion protein; chemoattractant cytokine; chemokine; cytokine; disease/disorder; experience; experiment; experimental research; experimental study; expiration; hToll; heavy metal Pb; heavy metal lead; host response; human subject; immune receptor; immunoresponse; infection resistance; living system; microorganism; migration; mutant; neutrophil; novel; overgrowth bacterial; p38; p38 MAPK Gene; p38Alpha; pathway; prevent; preventing; programs; receptor; recruit; research study; resistance to Bacteria; resistance to Bacterial; resistant; resistant to Bacteria; resistant to Bacterial; response; social role; study design; translation research enterprise; vertebrata",Role of CD14 and other innate immune receptors in severe sepsis,,23859,ZRG1,Special Emphasis Panel,,23,381150,
7758768,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI023990-24,,NIAID:407221;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,PATHOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GALLI, STEPHEN J;",1868212;,5R01AI023990,09/01/1986,01/31/2011,"1-Phosphatidylinositol 3-Kinase; 1H-Imidazole-4-ethanamine; 2,4-DNP; 2,4-Dinitrophenol; 3,4,5-PIP3; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; APF-1; ATGN; ATP-Dependent Proteolysis Factor 1; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Abbreviations; Accounting; Address; Affect; Affinity; Allergic; Allergic asthma; Anaphylactic Reaction; Anaphylaxis; Antibodies; Antigens; Asthma; Atopic Dermatitis; Attention; BUdR; BZS; Basophilic Histiocyte; Basophils, Tissue; Blood Serum; Body Tissues; Bone Marrow; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Bronchial Asthma; Broxuridine; CD 23 Antigens; CD117 Antigens; CD23 Antigens; CDK; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Degranulation; Cell Signaling; Cell Survival; Cell Viability; Cell secretion; Cellular Secretion; Chromosome 10; Chromosomes, Human, Pair 10; Chymase; Colony-Stimulating Factor 2 Alpha; Common Rat Strains; Coupling; Cues; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; DIF; DNP; Dermal; Dermatitis, Atopic; Development; Disease; Disorder; EC 2.5.1.18; EC 2.7; EC 2.7.2-; EDN1; ERK MAP Kinases; ES cell; ET-1; ET-1 (Endothelin-1); Eczema, Atopic; Effector Cell; Elements; Endothelin Type 1; Endothelin-1; Eosinophil-Mast Cell Growth-Factor; Erythrocyte Burst-Promoting Factor; Esters; Exhibits; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Extrinsic asthma; Fetal Liver; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GFP; GST; GTP GDP exchange factor; GeneHomolog; Genetic Alteration; Genetic Change; Genetic defect; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione Transferase; Goals; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; HMG-20; Hematopoietic Cytokine; Heme Transfer Protein; Hexosaminidases; High Mobility Protein 20; Histamine; Histocytochemistry; Homolog; Homologous Gene; Homologue; Human; Human, General; IL-3; IL-3(H); IL3 Protein; INFLM; IgE; IgE Receptors; Immune response; Immunoglobulin E; Immunoglobulin E Receptor; In Vitro; Individual; Inflammation; Inflammation Mediators; Interleukin 3 (Colony-Stimulating Factor, Multiple); Interleukin 3 Precursor; Interleukin-3; Interleukins; Intracellular Communication and Signaling; Iodide, Propidium; Kinases; L-Serine; Leukotrienes; Ligandins; Lipids; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MCGF; MEKs; MGF Stem Cell Factor; MHAM; MMAC1; MMCP-1; MULTI-CSF; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Mast Cell Growth Factor; Mast Cell Growth Factor Receptor; Mast-Cell Colony-Stimulating Factor; Mast-Cell Growth Factor; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mitogen-Activated Protein Kinases; Moab, Clinical Treatment; Molecular; Monoclonal Antibodies; Multilineage-Colony-Stimulating Factor; Multipotential Colony-Stimulating Factor; Murine; Mus; Mutation; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; Nucleotides; P-CSF; P-Cell Stimulating Factor; PI-3 Kinase; PI-3K; PI3-Kinase; PTEN; PTEN gene; PTEN1; Passive Cutaneous Anaphylaxis; Patients; Peritoneal; Phenotype; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Propidium Diiodide; Prostaglandins; Prostanoids; Proteins; Proto-Oncogene Protein c-kit; PtdIns 3-Kinase; PtdIns(3,4,5)P3; RX[{..}]glutathione R-transferase; Rat; Rattus; Receptor Protein; Receptors, IgE; Recombinants; Regulation; Reporting; Reticuloendothelial System, Bone Marrow; Rhinitis; Role; S-Hydroxyalkyl Glutathione Lyase; SCF Receptor; Serine; Serum; Serum Albumin; Shock, Anaphylactic; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Steel Factor; Stem Cell Factor; Stem Cell Factor Receptor; Structure; TLR protein; TNF; TNF (unspecified); TNF A; TNF Receptor Ligands; TNF gene; TNF-alpha; TNFSF2; Threonine/Tyrosine Protein Kinase; Tissues; Toll-like receptors; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Uridine, 5-bromo-2'-deoxy-; VPS; Vacuolar Protein Sorting; Venous; Work; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; allergic dermatitis; allergic eczema; atopic asthma; beta-Hexosaminidase; beta-N-Acetyl-D-hexosaminidase; beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase; beta-N-Acetyl-hexosaminidase; beta-n-acetylhexosaminidase; biological signal transduction; burden of disease; burden of illness; c kit; c-kit Ligand; c-kit Protein; c-kit Receptor; cdk Proteins; chymase-1; chymotrypsin-like protease; cytokine; disease burden; disease/disorder; economic cost; embryonic stem cell; epsilon Fc Receptors; exchange factor; extracellular signal related kinase; extrinsic allergic asthma; gene product; genome mutation; glutathione aralkyltransferase; glutathione aryltransferase; hematopoietic growth factor; hexosaminidase; histochemistry; histochemistry/cytochemistry; host response; immunogen; immunoresponse; in vivo; kit Ligand; kit Proto-Oncogene Protein; mast cell; mast cell protease; mast cell protease 1; mast cell protease I; mast cell proteinase-1; mastocyte; mutant; novel therapeutic intervention; p145(c-kit); p145c-kit; phosphatidylinositol 3,4,5-triphosphate; phosphatidylinositol 3,4,5-trisphosphate; receptor; response; skeletal muscle protease; social role; stem cell of embryonic origin; subcutaneous; tensin; tensin1; tumor necrosis factor (unspecified); ubiquination; ubiquitin conjugation; ubiquitin ligase; unspecified interleukin; years of life lost to disability; years of life lost to disease",Regulation of Mast Cell Development and Function,,23990,CMI,Cellular and Molecular Immunology - A,,24,407221,
7762202,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI024340-23,,NIAID:318272;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ALBUQUERQUE,UNITED STATES,BIOLOGY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"LOKER, ERIC SAMUEL;",1868208;,5R01AI024340,12/01/1986,02/28/2011,"Address; Area; Attenuated; Australorbis; Bilharzia; Biological Models; Biology; Biomphalaria; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Coagulation Factor I; Coagulation Factor One; Complement; Complement Proteins; Data; Detection; Development; Echinostoma; Exposure to; FLR; Factor I; Factor One; Failure (biologic function); Fibrinogen; Foundations; Fresh Water; Freshwater; Funding; Future; Gene Expression; Genes; Goals; Health; Helminths; Host Defense Mechanism; Human; Human, General; Immunosuppressants; Immunosuppressive Agents; Individual; Infection; Investigators; Laboratories; Larva; Learning; Legal patent; Man (Taxonomy); Man, Modern; Measures; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Molecular; Monitor; Natural Resistance; Nature; Nested PCR; Nested Polymerase Chain Reaction; Parasites; Patents; Population; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Radiation; Reaction; Reagent; Research; Research Personnel; Researchers; Resistance; S. mansoni; Schistosoma; Schistosoma mansoni; Schistosome; Snails; Sporocysts; Techniques; Testing; Transcript; Trematode Infections; Work; Worms, Parasitic; abstracting; base; defense response; design; designing; experience; experiment; experimental research; experimental study; failure; field study; gene product; genome sequencing; immunosuppressive; interest; pathogen; programs; ray (radiation); research study; resistant; response; tool; trematodiasis",BIOLOGY OF TREMATODE-SNAIL ASSOCIATIONS,,24340,ZRG1,Special Emphasis Panel,,23,318272,
7761250,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI026109-22,,NIAID:504135;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"TATTERSALL, PETER ;",1865284;,5R01AI026109,04/01/1988,01/31/2014,"Alien; BPTP3; Binding; Binding (Molecular Function); Binding Sites; Biochemical; CFC; CHIP assay; Cancers; Capsid; Cell Culture System; Cell Culture Techniques; Cell Nucleus; Cells; ChIP (chromatin immunoprecipitation); Childhood; Combining Site; Communicable Diseases; DNA; DNA Damage; DNA Injury; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; DNA, Viral; Deoxyribonucleic Acid; Ear; Ear structure; Elements; Flanking Repeat Sequences; Frequencies (time pattern); Frequency; Genes; Genetic; Genome; Goals; Host Defense; Human; Human Virus; Human, General; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Knowledge; Learning; Left; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mice; Mice Minute Virus; Mice, Mutant Strains; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Molecular Motors; Motor; Murine; Mus; Mutant Strains Mice; NS1; Natural History; Nature; Nucleoproteins; Nucleosomes; Nucleus; Organism; PTP-1D; PTP2C; PTPN11; PTPN11 gene; Parvovirus; Picodnavirus; Population; Process; Programs (PT); Programs [Publication Type]; Proteins; Reactive Site; Replication Initiation; Replication Origin; Research; Role; SH-PTP2; SH-PTP3; SHP-2; SHP2; SUBGP; Structure; Subgroup; System; System, LOINC Axis 4; Terminal Repeat; Terminal Repeat Sequences; Transgenes; Viral; Viral Genome; Virus; Viruses, General; chromatin immunoprecipitation; coat (nonenveloped virus); gene product; genome, mouse; in vivo; living system; malignancy; melting; mouse genome; mouse mutant; mutant; neoplasm/cancer; ori Region; parvovirus group; pathogen; pediatric; plasmid vaccine; positional cloning; programs; public health relevance; response; reverse genetics; social role; telomere; vector; vector vaccine; viral DNA; virus DNA",Molecular Genetics of Parvoviral DNA Replication," This research program aims to develop an understanding of the mechanisms underlying parvoviral DNA replication and packaging, and further our knowledge of parvoviruses as pathogens. These are also necessary prerequisites for the use of these viruses as vaccine vectors against infectious diseases and cancer. The newly discovered human parvovirus, HBoV, appears to be one of the most prevalent infections of childhood, and understanding its natural history and mode of replication will become of increasing importance as we discover more about its interaction with the human population. In the present renewal application, therefore, we propose to parlay what we know about parvoviral genome structure and DNA replication from the murine system into a study of similar processes that regulate replication of the human virus.",26109,VIRA,Virology - A Study Section,,22,504135,
7761269,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI026289-22,,NIAID:520607;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"MEKALANOS, JOHN J;",1863191;,5R01AI026289,05/01/1988,01/31/2014,"Address; Adherence; Adherence (attribute); Agar; Amoeba; Amoeba genus; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Assay; Award; Bacteria; Bacterial Infections; Bacteriophage T4; Bacteriophages; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biology; Blood erythrocyte; Blood normocyte; Body Tissues; Burn injury; Burns; C-terminal; CF patients; Cell Membrane Lipids; Cell surface; Cells; Chronic; Clip; Coliphage T4; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Complex; Data; Devices; Dictyostelium; Diffuse; Disease; Disorder; Drugs; E coli; Editorial Comment; Editorial Comment (PT); Employee Strikes; Enterobacteria phage T4; Erythrocytes; Erythrocytic; Escherichia coli; Extracellular Protein; Funding; Gene Cluster; Gene Expression; Genes; Genetic Screening; Goals; Host Defense Mechanism; Human; Human, General; Immunization; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Immunosuppressed Host; In Vitro; Individual; Infection; Investigation; Island; Killings; Lactamase; Light; Lung; Lytotoxicity; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Medication; Membrane; Membrane Lipids; Microbe; Microorganisms, General; Modeling; Motor; Movement; N-terminal; NH2-terminal; Organelles; Organism; Ortholog; Orthologous Gene; P. aeruginosa; P.aeruginosa; Pathogenicity Factors; Penetration; Phages; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Photoradiation; Predatory Behavior; Preparation; Process; Programs (PT); Programs [Publication Type]; Protein Export; Protein Export Pathway; Protein Secretion; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Published Comment; Publishing; Puncture procedure; Punctures; Rat; Rattus; Reader; Reading; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Research; Resistance; Respiratory System, Lung; Reticuloendothelial System, Erythrocytes; Sensitization, Immunologic; Sensitization, Immunological; Sputum; Strikes; Strikes, Employee; Structure; Study Section; Surface; System; System, LOINC Axis 4; T4 Phage; Tail; Testing; Therapeutic; Tissues; Torque; Transcription Activation; Transcriptional Activation; Translating; Translatings; Tube; Up-Regulation; V. cholerae; V.cholerae; Vaccines; Vibrio cholerae; Vibrio comma; Viewpoint; Viewpoint (PT); Virulence; Virulence Factors; Work; analog; bacterial disease; bacterial virus; base; blood corpuscles; body movement; cell envelope; cystic fibrosis patients; cytotoxic; cytotoxicity; disease/disorder; drug discovery; drug/agent; experiment; experimental research; experimental study; gene function; gene product; immunosuppressed patient; improved; injured; language translation; living system; macrophage; membrane structure; microorganism; model organism; mutant; nano machine; nanomachine; particle; pathogen; patients with CF; patients with cystic fibrosis; predation; prevent; preventing; programs; prophylactic; protein complex; protein protein interaction; public health relevance; pulmonary; research study; resistant; response; small molecule",Coordinate Regulation of Bacterial Virulence Factors," 7. Project Narrative The bacterium Pseudomonas aeruginosa is the cause of severe infections in burn, immunocompromised and cystic fibrosis patients. In order to cause disease, this bacterium requires a tiny machine called the Type VI secretion system (T6SS). The T6SS likely transports toxic proteins into human cells as part of its function. The proposed study seeks to understand how the T6SS `nanomachine' drills holes into host cells and then injects proteins that kill or alter the function of human cells. Because no vaccine exists for this organism, these studies may also provide a new way to prevent disease due to this bacterium.",26289,BACP,Bacterial Pathogenesis Study Section,,22,520607,
7756653,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI026782-20,,NIAID:598092;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,,02,064367329,US,PA,191112434,INSTITUTE FOR CANCER RESEARCH,"HARDY, RICHARD R;",1868196;,5R01AI026782,12/01/1989,01/31/2012,"21+ years old; ALL - Acute Lymphocytic Leukemia; Acute Lymphoid Leukemia; Adult; Ak-Tate; Apoptosis; Apoptosis Pathway; Area; Articulose-50; Arts; Autoantibodies; Autoimmune; Autoimmune Process; B Cell Proliferation; B blood cells; B-Cell CLL; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Cell Development; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; BCR Signaling Pathway; Balpred; Blood Serum; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD19; CD19 gene; Cell Communication and Signaling; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cells; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Competence; Cytofluorometry, Flow; Cytokine Signal Transduction; Cytokine Signaling; Deltacortilen; Deltastab; Development; Diopred; Disease; Disorder; Econopred; Exhibits; Fetal Liver; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fostering; Gene Expression; Generations; Genes; Goals; Grant; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hexacortone; Human; Human, Adult; Human, General; Hydrocortancyl; IL-7; IL7 Protein; Immunity; Inf-Oph; Inflanefran; Interleukin 7 Precursor; Interleukin-7; Intracellular Communication and Signaling; Key-Pred; Label; Laboratories; Lead; Leukemia, B-Cell; Leukemia, Lymphocytic, Acute; Locaseptil-Neo; Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Chronic; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; Lymphopoiesis; Lymphopoietin-1; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Method LOINC Axis 6; Methodology; Mice; Mice, Mutant Strains; Microfluorometry, Flow; Modeling; Mouse Strains; Murine; Mus; Mutant Strains Mice; Neonatal; Neoplasms; Ophtho-Tate; Pathway interactions; Pattern; Pb element; Phenotype; Play; Population; Portraits; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Pred Fort; Pred Forte; Pred Mild; Predaject; Predalone; Predate; Predcor; Prednefrin SF; Predni-H; Predni-POS; Prednihexal; Predniocil; Process; Progenitor Cell Transplantation; Proliferating; Research; Reticuloendothelial System, Bone Marrow; Role; SCID; SCID Mice; Serum; Severe Combined Immunodeficient Mice; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem Cell Transplantation; Stem cell transplant; Surface; TSLP; TSLP gene; Testing; Time; Tumors; V(pre-B)-lambda5 surrogate light chain; VpreB-lambda 5 SL; Work; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; adult human (21+); aged; autoimmune antibody; base; biological signal transduction; chronic lymphoid leukemia; design; designing; digital; disease/disorder; fetal; flow cytophotometry; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; insight; lymphocytopoiesis; mouse mutant; neoplasia; neoplastic growth; novel; pathway; progenitor; psiL chain; response; self reactive antibody; severe combined immune deficiency; social role; surrogate light chain",LY-1 B Cells: Developmental Origins and V Gene Biases,,26782,ZRG1,Special Emphasis Panel,,20,598092,
7758248,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI028900-20,,NIAID:615217;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"LEVY, DAVID E.;",1926428;,5R01AI028900,01/01/1990,01/31/2011,"ATF; Achievement; Achievement Attainment; Animal Cancer Model; AnimalModel; Animals; Antibodies; Binding; Binding (Molecular Function); Biochemical; Biological; Biological Function; Biological Process; Biology; C-terminal; Cancer Biology; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Signaling; Cells; Cellular biology; Characteristics; Collection; Competence; Complex; Cytokine Signal Transduction; Cytokine Signaling; Cytoplasm; Data; Development; Diagnosis; Dimerization; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Embryo Development; Embryogenesis; Embryonic Development; Family; Family member; Future; Gene Expression; Gene Transcription; Genetic; Genetic Transcription; Goals; IFN-stimulated gene factor 3 complex; ISGF-3; ISGF3 factor; ISGF3 protein; Immune; Inflammatory Response; Intracellular Communication and Signaling; L-Tyrosine; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mediating; Modeling; Molecular; Molecular Interaction; Mother Cells; Motivation; Normal Cell; Nuclear Translocation; Oncogene Products; Oncogene Proteins; Oncoproteins; Pathway interactions; Play; Process; Progenitor Cells; Protein Dimerization; Proteins; RNA Expression; Regulation; Regulatory Protein; Research; Research Resources; Resources; Role; SH2 Domains; STAT protein; STAT1; STAT1 gene; STAT3; STAT3 gene; STAT91; Signal Transducer and Activator of Transcription; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Stimulus; TYR; Therapeutic; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Transducers; Tumor Suppressor Proteins; Tyrosine; Tyrosine Phosphorylation; Tyrosine, L-isomer; activating transcription factor; animal tissue; base; biological signal transduction; cancer progression; cell biology; disease/disorder; extracellular; gene product; genetic regulatory protein; human disease; interferon-stimulated gene factor 3; malignancy; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; new approaches; novel; novel approaches; novel strategies; novel strategy; para-Tyrosine; pathway; regulatory gene product; social role; src Homology Region 2 Domain; tool; transcription factor ISGF3; trophoblast; tumor; tumor progression; tumor suppressor",ISGF3 Transcription Factor Family in Cytokine Signaling,,28900,ZRG1,Special Emphasis Panel,,20,615217,
7758218,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI029646-21,,NIAID:657134;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"BEVERLEY, STEPHEN M;",1872235;,5R01AI029646,03/01/1990,01/31/2011,"2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3; 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Actinomycin A IV; Actinomycin C1; Actinomycin D; Actinomycin I1; Actinomycin IV; Actinomycin X 1; Actinomycin-[thr-val-pro-sar-meval]; Adopted; Algorithms; Autophagocytosis; Back; Biological; Cell Volumes; Chromates; Chromatin; Chromatin Structure; Communities; Comparative Genome Hybridization; Cosmegen; Country; DACT; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Dactinomycin; Dactinomycine; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Detection; Development; Diploid; Diploidy; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7.7.6; Eukaryota; Eukaryote; Evolution; Expression Profiling; Expression Signature; Gene Cluster; Gene Expression; Gene Expression Profile; Gene Transcription; GeneHomolog; Genes; Genetic; Genetic Transcription; Genetic analyses; Genetics-Mutagenesis; Genome; Genomics; Global Change; Goals; Grant; Homolog; Homologous Gene; Homologue; Image; Immunologic Deficiency Syndrome, Acquired; In Vitro; Infection; Investigators; Label; Leishmania; Leishmania (Leishmania) major; Leishmania (genus); Leishmania major; Leishmania tropica major; Leishmaniasis; Lesion; Link; Lyovac cosmegen; Maps; Mediating; Meractinomycin; Metabolic Pathway; Method LOINC Axis 6; Methodology; Methods; Middle East; Molecular; Molecular Biology, Mutagenesis; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Mutagenesis; Nature; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nutrient; Oligonucleotide Array; Oligonucleotide Microarrays; Opportunistic Infections; Oxidants; Oxidizing Agents; Parasites; Pathway interactions; Patients; Pattern; Persons; Physical condensation; Play; Polyribosomes; Polysomes; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Quelling; RNA Expression; RNA Interference; RNA Polymerases; RNA Silencing; RNA Silencings; RNA Stability; RNAi; Relative; Relative (related person); Research; Research Personnel; Research Resources; Researchers; Resources; Role; Sand Flies; Sequence-Specific Posttranscriptional Gene Silencing; Spottings; Stability, mRNA; Staging; Stimulus; Structure; Survey Instrument; Surveys; Temperature; Testing; Thiouracil; Time; Transcription; Transcription, Genetic; Translations; Tropical Disease; Virulence; Volumes, Cell; antimicrobial peptide; asexual; autophagy; base; clinical data repository; clinical data warehouse; comparative genomic hybridization; condensation; data repository; electron acceptor; eukaryotida; expression vector; functional genomics; gene expression signature; genetic analysis; genetic manipulation; genome-wide; imaging; improved; in vivo; knockout gene; mRNA Stability; metacyclogenesis; molecuar profile; molecular signature; mutant; parasite genome; pathway; positional cloning; programs; relational database; response; reverse genetics; social role; success; tool; transcriptome; vector",MOLECULAR GENETICS OF LEISHMANIA,,29646,PTHE,Pathogenic Eukaryotes Study Section,,21,657134,
7760850,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI030084-18,,NIAID:358351;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"STENSON, WILLIAM F.;",2423271;,5R01AI030084,02/01/1992,01/31/2011,"Abscess, Hepatic; Abscess, Hepatic, Amebic; Acids; Amebiasis; Amebic Liver Abscess; Amebic colitis; Amoeba; Amoeba genus; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Authorization; Authorization documentation; Bacteria; Binding; Binding (Molecular Function); Biological; Biological Symbiosis; Biology; Blood Circulation; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood-Borne Pathogens; Bloodborne Pathogens; Bloodstream; Body Tissues; CHRM1; CHRM1 gene; COX-2; COX2; Caspase Gene; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Circulation; Cities; Cola; Cold-Insoluble Globulins; Colon; Complement; Complement Proteins; Complex; Cysteine Endopeptidases; Cysteine Protease; Cysteine Proteinases; Cytokines, Chemotactic; DISSEC; Defensins; Disclosure; Disease; Disease model; Disorder; Dissection; Dysentery, Amebic; Dysfunction; E. histolytica; Endamoeba histolytica; Entamoeba histolytica; Environment; Epithelial Cells; Equation; Esteroproteases; Exhibits; Extracellular Matrix Proteins; FN1; FNZ; Face; Fatty Acids, Short-Chain; Fatty Acids, Volatile; Fermentation; Fibronectin 1; Fibronectins; Food; Functional disorder; Funding; Gal-GalNAc; Gene Expression; Gene Expression Profile; Gene Products, RNA; Genes; Genome; Genus Cola; HM1; Health; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Hepatic Amebiasis; Heterograft; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Host Defense; Human; Human Resources; Human, General; Hydrogen Oxide; INFLM; Immune; Immune response; In Situ; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory Response; Information Disclosure; Instruction; Intercrines; Intestinal; Intestinal Amebiasis; Intestines; Intracellular Communication and Signaling; Invaded; Investigators; Killings; Knowledge; LETS Proteins; Large External Transformation-Sensitive Protein; Last Name; Lectin; Link; Liver; Liver Abscess; Liver Abscess, Amebic; Mammals, Mice; Man (Taxonomy); Man, Modern; Manpower; Marrow Neutrophil; Mediating; Methods and Techniques; Methods, Other; Mice; Microscope; Mitochondria; Modeling; Molecular; Molecular Interaction; Mucins; Mucosa; Mucosal Tissue; Mucous Membrane; Mucus Glycoprotein; Murine; Mus; Names; Nature; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Oligo; Oligonucleotides; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Oxygen measurement, partial pressure, arterial; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Parasites; Pathogenesis; Pathogenicity Factors; Pathway interactions; Peptidases; Peptide Hydrolases; Peptides; Permission; Phagocytosis; Physiologic; Physiological; Physiopathology; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Position; Positioning Attribute; Principal Investigator; Printing; Production; Programs (PT); Programs [Publication Type]; Progress Reports; Proteases; Proteinases; Proteolytic Enzymes; Public Health; R01 Mechanism; R01 Program; RNA; RNA, Non-Polyadenylated; RPG; Reagent; Receptor Protein; Registries; Regulation; Reports, Progress; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rest; Ribonucleic Acid; Role; SCID; SCID Mice; SIS cytokines; Severe Combined Immunodeficient Mice; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Thiol Protease; Time; Tissues; Transgenic Organisms; Transplantation, Heterologous; Universities; Virulence; Virulence Factors; Virulent; Volatile Fatty Acids; Washington; Water; Work; Xenograft; Xenograft procedure; Xenotransplantation; alpha 2-Surface Binding Glycoprotein; anti-microbial; antimicrobial; arterial pO2; base; biological signal transduction; body system, hepatic; bowel; chemoattractant cytokine; chemokine; cultured cell line; cytokine; design; designing; disease/disorder; disorder model; experiment; experimental research; experimental study; extracellular; facial; free radical oxygen; gene expression signature; hCOX-2; hESC; host response; human ES cell; human ESC; human embryonic stem cell; immunoresponse; inhibitor; inhibitor/antagonist; insight; laser capture microdissection; macromolecule; macrophage; mitochondrial; model organism; mouse model; neutrophil; new vaccines; next generation vaccines; novel vaccines; organ system, hepatic; oxygen tension; parasitism; pathogen; pathophysiology; pathway; personnel; programs; public health medicine (field); receptor; research study; response; severe combined immune deficiency; social role; transcription factor; transcriptome; transgenic; weapons",Molecular Dissection of E. Histolytica Pathogenesis,,30084,ZRG1,Special Emphasis Panel,,18,358351,
7762192,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI031077-17,,NIAID:450296;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,070967955,US,WA,98109,SEATTLE BIOMEDICAL RESEARCH INSTITUTE,"PARSONS, MARILYN ;",7360443;,5R01AI031077,02/01/1992,01/31/2011,"ATP-protein phosphotransferase; Affect; African Sleeping Sickness; African Trypanosomiasis; American; American trypanosome; Armed Forces Personnel; Bio-Informatics; Biogenesis; Bioinformatics; Biological; Biological Models; Blood Circulation; Bloodstream; Cancers; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Division Cycle; Cell Signaling; Cell membrane; Cellular Metabolic Process; Chronic; Chronic Disease; Chronic Illness; Circulation; Clinical Trials; Clinical Trials, Unspecified; Complement; Complement Proteins; Cytoplasmic Membrane; Cytosolic Protein Tyrosine Phosphastase; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EC 2.7; EC 2.7.2-; Environment; Eukaryota; Eukaryote; Extracellular Signal-Regulated Kinases; Face; Family; GWAS; Gene Family; Gene Proteins; GeneHomolog; Generalized Growth; Genes; Genome; Genomics; Goals; Grant; Growth; Homolog; Homologous Gene; Homologue; Human; Human Biology; Human, General; Informatics; Intracellular Communication and Signaling; Investigators; Kinases; Knowledge; L-Tyrosine; Lead; Leishmania; Leishmania (Leishmania) major; Leishmania (genus); Leishmania major; Leishmania tropica major; Light; Link; MAP Kinase Kinases; MAP kinase; MAP2K1; MAP2K1 gene; MAPK; MAPK Kinases; MAPKK1; MAPKKs; MEK1; MKK1; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Medication; Messenger RNA; Metabolic Process, Cellular; Middle East; Military; Military Personnel; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Model System; Models, Biologic; Monitor; Morphology; Nature; Obesity; Organism; Origin of Life; PRKMK1; PTP-1B; PTP1B; PTPN1; PTPN1 gene; PTPase; Parasites; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Photometry/Spectrum Analysis, Mass; Photoradiation; Plasma Membrane; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Gene Products; Protein Kinase; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Tyrosine Phosphatase; Protein phosphatase; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Receptor Protein; Regulation; Research; Research Personnel; Researchers; Ribosomes; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Stimulus; Stress; Structure; T. brucei; T. cruzi; TM Domain; TYR; Testing; Tissue Growth; Transmembrane Domain; Transmembrane Region; Transphosphorylases; Trypanosoma; Trypanosoma brucei; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosome; Trypanosomiasis, African; Tyrosine; Tyrosine Phosphatase; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosyl Phosphoprotein Phosphatase; Vaccines; adiposity; biological signal transduction; chronic disease/disorder; chronic disorder; clinical investigation; combat; corpulence; corpulency; corpulentia; diabetes; disease/disorder; drug/agent; eukaryotida; experiment; experimental research; experimental study; facial; gene function; gene product; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human disease; hydroxyalkyl protein kinase; interest; living system; mRNA; malignancy; modulator protein; mutant; necrocytosis; neoplasm/cancer; novel; obese; obese people; obese person; obese population; ontogeny; para-Tyrosine; pathogen; pathway; phosphatase inhibitor 2; phosphoprotein phosphatase inhibitor-2; phosphorylase b kinase kinase; plasmalemma; programs; protein phosphatase inhibitor-2; protein tyrosine phosphate phosphohydrolase; receptor; research study; response; sleeping sickness; social role; whole genome association studies; whole genome association study",Protein Phosphorylation in Trypanosomes,,31077,PTHE,Pathogenic Eukaryotes Study Section,,17,450296,
7759195,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI031473-13,,NIAID:246439;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,PATHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"NAHM, MOON H.;",1935397;,5R01AI031473,07/01/1991,01/31/2012,"0-11 years old; 21+ years old; Adonitol; Adult; Aged 65 and Over; Alleles; Allelomorphs; Antibodies; Base Sequence; Biochemical; Blood Serum; C 1 Esterase; C1 Esterase; C1 s; C1s; CAPS; Capsules; Care, Health; Chemicals; Child; Child Youth; Children (0-21); Chromatography, Gas-Liquid-Mass Spectrometry; Clinical; Code; Coding System; Complement 1 Esterase; Complement 1s; Complement component C1s; Conjugate Vaccines; D-Galactose; D. pneumoniae; D.pneumoniae; DNA Sequence; Deoxymannose; Diplococcus pneumoniae; EC 2; Elderly; Elderly, over 65; Funding; GC MS; GCMS; Galactopyranose; Galactopyranoside; Galactose; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glycans; Healthcare; Human; Human, Adult; Human, Child; Human, General; Immunity; Investigators; Label; Macromolecular Structure; Man (Taxonomy); Man, Modern; Mannose, 6-deoxy-; Mass Fragmentographies; Mass Fragmentography; Measures; Moab, Clinical Treatment; Modeling; Molecular Structure; Monoclonal Antibodies; Monosaccharides; Moods; Mutation; Names; Nucleotide Sequence; Pneumococcal conjugate vaccine; Pneumococcal vaccine; Pneumococcus; Polysaccharides; Population; Prevalence; Programs (PT); Programs [Publication Type]; Reporting; Republic of South Africa; Research; Research Personnel; Researchers; Rhamnose; Ribitol; Role; S. pneumoniae; Serotyping; Serum; South Africa; Spectrometry, Mass-Gas Chromatography; Spectrum Analysis, Mass-Gas Chromatography; Streptococcus pneumoniae; Streptococcus pneumoniae vaccine; Transferase; Transferase Gene; Union of South Africa; Vaccination; Vaccines; Vaccines, Conjugate; adult human (21+); adult youth; advanced age; capsule (pharmacologic); children; elders; genome mutation; geriatric; interest; ion trap mass spectrometry; late life; later life; mass fragmentometry; nucleic acid sequence; older adult; older person; pathogen; programs; senior citizen; social role; tool; vaccine efficacy; young adult; youngster",Impact of a new group 6 serotype on pneumococcal vaccines,,31473,VMD,Vaccines Against Microbial Diseases Study Section,,13,246439,
7759533,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI031940-20,,NIAID:590547;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,AURORA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"HOLMES, RANDALL K;",1903118;,5R01AI031940,02/01/1992,01/31/2012,"3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; AC Globulin; ADP ribosylation; ADP-ribosylation factor 6; ARF 6 protein; ARF6 protein; ATGN; ATP pyrophosphate-lyase (cyclizing); Accounting; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adhesins, Bacterial; Adjuvant; Affect; Antibodies; Antibodies, Blocking; Antigens; Bacterial Adhesins; Bacterial Infections; Binding; Binding (Molecular Function); Biological; Blocking Antibodies; Blood Coagulation Factor V; Cells; Cessation of life; Chimera; Chimera organism; Cholera; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Cholera Vaccine; Choleragen; Coagulation Factor V; Cyclic AMP; Cytosol; Death; Developing Countries; Developing Nations; Development; Diarrhea; Disease; Disorder; E coli; ETEC; Electrolytes; Endocytosis; Endoplasmic Reticulum; Enterocytes; Enterotoxins; Ergastoplasm; Escherichia coli; Escherichia coli Infections; Factor Pi; Factor V; Fluids and Secretions; G-Proteins; GM1-ganglioside receptor; GTP-Binding Proteins; GTP-Regulatory Proteins; Gastrointestinal Tract, Small Intestine; Genetic analyses; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heating; Human; Human, General; Infections, E coli; Intestinal; Intestines; Intestines, Small; Knowledge; Less-Developed Countries; Less-Developed Nations; Lipid Rafts, Cell Membrane; Man (Taxonomy); Man, Modern; Measures; Membrane Microdomains; Methods; Molecular; Molecular Interaction; Molecular Probes; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Pathogenesis; Pathogenicity Factors; Physiologic; Physiological; Pilum; Proaccelerin; Proteins; Proteus mirabilis; Public Health; Role; SUBGP; Sanitation; Signal Pathway; Small Intestines; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; Subgroup; Testing; Third-World Countries; Third-World Nations; Toxic effect; Toxicities; UTI; Under-Developed Countries; Under-Developed Nations; United States; Urinary tract; Urinary tract infection; Urinary tract infectious disease; V. cholerae; V.cholerae; Vaccines; Variant; Variation; Vibrio; Vibrio cholerae; Vibrio comma; Virulence Factors; Work; World Health; adenosine 3'5' monophosphate; adenylcyclase; adhesin; bacterial disease; base; bowel; cAMP; colonization factor antigens; design; designing; disease/disorder; enterotoxigenic E. coli; enterotoxigenic E.coli; enterotoxigenic Escherichia coli; experiment; experimental research; experimental study; fimbriae; ganglioside receptor; gene product; genetic analysis; immunogen; immunogenicity; insight; labile component; labile factor; lipid raft; mucosal vaccine; new vaccines; next generation vaccines; novel; novel vaccines; pilus; polypeptide; prevent; preventing; protein protein interaction; public health medicine (field); research study; small bowel; social role; technology development; toxin V; trafficking; vaccine candidate",Genetic Analysis of Cholera Toxin Structure and Function,,31940,BACP,Bacterial Pathogenesis Study Section,,20,590547,
7758321,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI031951-18,,NIAID:320393;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TUCSON,UNITED STATES,BIOCHEMISTRY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"MIESFELD, ROGER L;",1869075;,5R01AI031951,02/01/1992,01/31/2011,"1-Phosphatidylinositol 4-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol-4-phosphotransferase; Aedes; Aedes (genus); Amino Acids; Blood; Blood Proteins; Cell Communication and Signaling; Cell Signaling; Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-, (2beta,3beta,5beta,22R)-; Culicidae; Digestion; EC 2.7; EC 2.7.1.67; Ecdysone; Egg Yolk Proteins; Endoplasmic Reticulum; Enzymes; Ergastoplasm; Event; Fat Body; Female; Funding; Gene Transcription; Genes; Genetic Transcription; Genital System, Female, Ovary; Hour; In Vitro; Ingestion; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Insecta; Insects; Intracellular Communication and Signaling; Invertebrates, Insects; Kinases; Lead; Lipids; Messenger RNA; Midgut; Modeling; Molting Hormone; Mosquitoes; NPIK; Oocytes; Ovary; Ovocytes; PI 4-Kinase; PI4K-Beta; PI4K92; PI4KBeta; PIK4CB; Pb element; Peptide Biosynthesis, Ribosomal; Peptides; Phase; Phosphatidyl Inositol; Phosphatidylinositiol Kinase; Phosphatidylinositol 4-Kinase; Phosphatidylinositol 4-Kinase Beta; Phosphatidylinositol 4-Kinase, Catalytic, Beta; Phosphatidylinositol 4-Kinase, Type III, Beta; Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive; Phosphatidylinositol Kinase Type II; Phosphatidylinositols; Phosphoinositide Kinase; Phosphoinositide-4-Kinase Catalytic Beta Polypeptide; Phosphoinositides; Phosphorylation; Phosphotransferases; Preparation; Process; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Phosphorylation; Protein Synthesis, Ribosomal; Proteins; Proteins, Yolk; PtdIns; PtdIns 4-Kinase; RNA Expression; RNA, Messenger; Regulation; Reticuloendothelial System, Blood; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Time; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Translations; Transphosphorylases; Tripcellim; Trypsin; Up-Regulation; Vitellogenesis; Weight; Work; aminoacid; biological signal transduction; computerized data processing; data processing; egg; feeding; gene induction; gene product; heavy metal Pb; heavy metal lead; mRNA; protein synthesis; reproductive; secretory protein; signal processing; small molecule; social role; sucking",Regulation of Digestion in Blood-Sucking Insects,,31951,ZRG1,Special Emphasis Panel,,18,320393,
7758281,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI032223-16,,NIAID:373284;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,PATHOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"WEIS, JANIS J;",1895651;,5R01AI032223,04/01/1993,01/31/2013,"Alpha-Beta-Omega Interferon Receptor-1; Animal Welfare; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antiinflammatories; Antiinflammatory Agents; Antiviral Protein Alpha Type; Arthritis; Arthritis in Lyme disease; Articulation; Award; B. burgdorferi; B.burgdorferi; Bibliography; Body Tissues; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; CSIF; CSIF-10; Cells; Country; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Development; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Expression Profiling; Expression Signature; Fibroblasts; Gene Expression; Genes; Hematopoietic; Host Defense; HuIFN-Alpha-Rec; IACUC; IFN; IFN-Alpha-REC; IFNBR; IFRC; IL-10; IL10; IL10A; IRBs; Impact, Environmental; Inbred C3H Mice; Infection; Inflammatory; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; Interferon Alpha-Beta Receptor Alpha Chain; Interferons; Interleukin 10 Precursor; Interleukin-10; International; Invaded; Joints; Lipoproteins; Lyme Arthritis; Lyme Disease Spirochete; MTGN; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Mice, Inbred C3H; Mitogens; Molecular Fingerprinting; Molecular Profiling; Mouse, C3H; Murine; Mus; Myelogenous; Myeloid; Order Spirochaetales; Pathology; Pathway interactions; Play; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; RNA, Small Interfering; RT-PCR; RTPCR; Radiation Chimera; Receptor Cell; Relative; Relative (related person); Research; Research Ethics Committees; Research Resources; Resources; Reverse Transcriptase Polymerase Chain Reaction; Role; Signal Pathway; Skin; Small Interfering RNA; Source; Spirochaetales; Spirochetes; TIL4; TLR2; TLR2 gene; Tissues; Toll/Interleukin 1 Receptor-Like 4 Gene; Vertebrate Animals; Vertebrates; Work; Wound Healing; Wound Repair; abstracting; arthritic; cell type; cytokine; disease phenotype; disease/disorder; experiment; experimental research; experimental study; expiration; gene induction; human subject; ifnar1 gene product; lyme spirochete; magnetic beads; molecuar profile; molecular signature; novel; pathway; programs; reconstitute; reconstitution; research study; response; reverse transcriptase PCR; sensor; siRNA; social role; tissue repair; type I IFN receptor; type I interferon receptor; vertebrata",Borrelia Burgdorferi Mitogen in Development of Arthritis,,32223,ZRG1,Special Emphasis Panel,,16,373284,
7759620,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI033170-18,,NIAID:343734;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NOTRE DAME,UNITED STATES,CHEMISTRY,02,824910376,US,IN,46556,UNIVERSITY OF NOTRE DAME,"MOBASHERY, SHAHRIAR ;",1875796;,5R01AI033170,08/01/1992,01/31/2011,"Active Follow-up; Antibacterial Drug Resistance; Antibacterial Drug Resistant; Antibacterial resistant; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antibiotics, Monobactam; Applications Grants; Bacteria; Bacterial Drug Resistance; Beta-Lactam resistant; Cell Communication and Signaling; Cell Signaling; Clinical; Cytoplasm; Drug Resistance, Bacterial; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Esteroproteases; Genes; Grant Proposals; Grants, Applications; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Knowledge; L-Serine; Lactam Antibiotics; Lactamase; Lactams; Miscellaneous Antibiotic; Monobactams; Monocyclic beta-Lactams; Nature; Organism; Penicillin-Binding Proteins; Peptidases; Peptide Domain; Peptide Hydrolases; Phenotype; Process; Property; Property, LOINC Axis 2; Protease Domain; Proteases; Protein Domains; Proteinases; Proteins; Proteolytic Domain; Proteolytic Enzymes; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; S. aureus; S.aureus; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Staphylococcus aureus; System; System, LOINC Axis 4; Tertiary Protein Structure; Transmembrane Protein; Work; anti-bacterial drug resistance; anti-bacterial drug resistant; anti-bacterial resistance; anti-bacterial resistant; antibacterial resistance; antibiotic resistant; b lactam resistance; b-lactam resistant; beta lactam antibiotic; beta lactam hydrolase; beta-Lactam Resistance; beta-Lactamase; beta-Lactamhydrolase; beta-Lactams; biological signal transduction; cost; design; designing; follow-up; gene product; inhibitor; inhibitor/antagonist; living system; pathogen; pathogenic bacteria; resistance mechanism; resistance to antibacterial; resistance to b lactam; resistance to beta-lactam; resistant; resistant mechanism; resistant to antibacterial; resistant to b lactam; resistant to beta-lactam; sensor",Resistance to beta-Lactam Antibiotics,,33170,ZRG1,Special Emphasis Panel,,18,343734,
7758184,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI033456-20,,NIAID:800339;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CAMBRIDGE,UNITED STATES,,08,120989983,US,MA,021421479,WHITEHEAD INSTITUTE FOR BIOMEDICAL RES,"PLOEGH, HIDDE L;",1888151;,5R01AI033456,01/01/1993,01/31/2013,"APF-1; ATGN; ATP-Dependent Proteolysis Factor 1; Abscission; Accounting; Affinity; Alleles; Allelomorphs; Anabolism; Animal Model; Animal Models and Related Studies; Animal Welfare; Antibodies; Antigen Presentation; Antigen Targeting; Antigens; B blood cells; B-Cells; B-Lymphocytes; Behavior; Bibliography; Biochemical; Biological; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CMV; CTL; Cell Surface Glycoproteins; Cell-Mediated Lympholytic Cells; Cells; Class I Antigens; Class I Major Histocompatibility Antigens; Complement; Complement Proteins; Complex Class 1; Country; Cross Presentation; Crosslinker; Cytolytic T-Cell; Cytomegalovirus; Cytoplasm; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; DNA Sequence Rearrangement; Data; Dislocations; Ecological impact; Endoplasmic Reticulum; Environment; Environmental Impact; Equipment; Ergastoplasm; Ethics Committees, Research; Excision; Extirpation; Extracellular Space; Generations; Genes, Class I; Genes, MHC Class I; Genetic; Glycoprotein Degradation; Glycoprotein Degradation Pathway; HCMV; HMG-20; Herpesviridae; Herpesviruses; High Mobility Protein 20; Histocompatibility Antigens Class I; IACUC; IRBs; Immune; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercellular Space; Intermediary Metabolism; International; Joint Dislocation; Knock-in; Knock-in Mouse; Left; Light; Lipids; METBL; MHC Class I; MHC Class I Genes; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; Major Histocompatibility Complex Class 1; Mammals, Mice; Membrane Glycoproteins; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods; Mice; Modeling; Murine; Mus; Names; Output; Ovalbumin; Pathogenicity; Pathway interactions; Peptides; Photoradiation; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Cleavage; Proteins; Proteolysis; Quality Control; Rearrangement; Removal; Research; Research Ethics Committees; Research Resources; Resources; Role; Route; Salivary Gland Viruses; Specific qualifier value; Specified; Surface; Surface Glycoproteins; Surgical Removal; T-Lymphocytes, Cytotoxic; Testing; Ubiquitin; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; aberrant protein folding; abnormal protein folding; abstracting; base; biosynthesis; cytomegalovirus group; experiment; experimental research; experimental study; expiration; fat metabolism; gene product; herpes virus; human cytomegalovirus; human subject; immunogen; in vivo; interest; lipid metabolism; model organism; mouse model; pathogen; pathologic protein folding; pathway; prevent; preventing; programs; protein mis-folding; protein misfolding; research study; resection; response; social role; vertebrata; viral infection; virus infection",Assembly of MHC Class I Molecules in Vitro and in Vivo,,33456,CMIA,Cellular and Molecular Immunology - A Study Section,,20,800339,
7759576,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI033600-15,,NIAID:412575;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ANDERSON, PAUL J.;",1871804;,5R01AI033600,02/01/1993,01/31/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; BRF Gene; BRF1; BRF1 gene; Cancers; Cells; Cellular Stress; Complex; Cytoplasmic Granules; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diabetes Mellitus; EC 2.7; Eukaryote; Eukaryotic Cell; Exonuclease; Exposure to; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Face; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Funding; General Transcription Factor 3B, 90-kD Subunit; Goals; Immunofluorescence Microscopy; Intermediary Metabolism; Kinases; Link; METBL; Malignant Neoplasms; Malignant Tumor; Mediating; Messenger RNA; Metabolic Processes; Metabolism; Micro RNA; MicroRNAs; Microscopy, Immunofluorescence; Molecular; Movement; Phosphotransferases; Polyribosomes; Polysomes; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RAFT1 protein, human; RAPT1 protein, human; RISC Multicomponent Nuclease; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNA-Induced Silencing Complex; RNAi; Rapamycin Target Protein; Regulation; Reporter; Research; Ribosomal Protein S6 Kinase; Role; S6 Kinase; S6-H4 Kinase; Sequence-Specific Posttranscriptional Gene Silencing; Site; Sorting - Cell Movement; Stress; Structure; TAF3B2 Gene; TAF3C, Formerly; TFIIIB90 Gene; Testing; Transcript; Transphosphorylases; Work; body movement; decapping enzyme; dementia of the Alzheimer type; diabetes; eukaryotida; facial; gene product; granule; human FRAP1 protein; knock-down; mRNA; mTOR; malignancy; miRNA; mutant; neoplasm/cancer; primary degenerative dementia; programs; rapamycin and FKBP12 target 1 protein, human; response; selective expression; selectively expressed; senile dementia of the Alzheimer type; social role; sorting",Characterization of mammalian stress granules,,33600,MGC,Molecular Genetics C Study Section,,15,412575,
7760541,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI037549-15,,NIAID:312805;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,FARMINGTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"WELLER, SANDRA K;",1903053;,5R01AI037549,04/01/1995,01/31/2011,"Active Transport, Cell Nucleus; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Bio-Informatics; Biochemical; Biochemistry; Bioinformatics; Biological Function; Biological Process; Biophysics; Capsid; Capsid Proteins; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chaperone; Chemistry, Biological; Coat Proteins; Complex; Cystic Fibrosis; DNA; DNA Molecular Biology; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Viral; Data; Deoxyribonucleic Acid; Development; Drugs; Encephalitis; Future; Genes; Genetic; Genome; Goals; Grant; HHV-1; HHV-2; HSP-90; HSP90; HSV; HSV-1; HSV-2; HSV1; HSV2; Head; Heat-Shock Proteins 90; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus 2; Herpes Simplex Virus Type 1; Herpes Simplex Virus Type 2; Herpes labialis Virus; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus hominis; Herpesvirus progenitalis; Herpesviruses; Human; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human herpes simplex virus type 1; Human herpes simplex virus type 2; Human herpesvirus 1; Human herpesvirus type 1; Human, General; Idiopathic Parkinson Disease; In Vitro; Infection; Inflammation, Brain; Lewy Body Parkinson Disease; Life Cycle; Life Cycle Stages; Man (Taxonomy); Man, Modern; Medication; Molecular; Molecular Biology; Molecular Chaperones; Monitor; Mucoviscidosis; Mutate; Nuclear Transport; Nucleocytoplasmic Shuttling; Oral; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Population; Primary Parkinsonism; Process; Protein-Folding Disease; Proteins; Reaction; Replication Process; Replication-Associated Process; Role; Sight; Simplexvirus; Subcellular Process; System; System, LOINC Axis 4; Tail; Testing; Therapeutic Intervention; Viral; Viral Coat Proteins; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Outer Coat Protein; Viral Proteins; Virus; Virus Diseases; Viruses, General; Vision; Work; aberrant protein folding; abnormal protein folding; base; cell biology; chaperone machinery; coat (nonenveloped virus); disulfide bond; drug discovery; drug/agent; gene product; genital infection; herpes simplex i; herpes simplex ii; herpes virus; herpes virus 1, human; herpesvirus; hsp90 Family; human alphaherpesvirus 1; human alphaherpesvirus 2; human disease; human herpesvirus 1 group; in vivo; interdisciplinary approach; intervention therapy; life course; macromolecular assembly; mutant; new approaches; novel; novel approaches; novel strategies; novel strategy; nucleocytoplasmic transport; pathogen; pathologic protein folding; prevent; preventing; protein mis-folding; protein misfolding; protein protein interaction; social role; terminase; treatment of viral infectious disease; uptake; viral DNA; viral infection; virus DNA; virus infection; virus protein",HSV 1 Processing/Packaging Genes,,37549,VIRA,Virology - A Study Section,,15,312805,
7758197,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI039639-13,,NIAID:222160;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WEST LAFAYETTE,UNITED STATES,PHARMACOLOGY,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"POST, CAROL B.;",1897831;,5R01AI039639,02/01/1997,01/31/2012,"Abbreviations; Accounting; Acute Nasopharyngitis; Address; Adhesives; Amino Acid Receptors; Animal Diseases; Antiviral Agents; Antiviral Drugs; Antivirals; Binding; Binding (Molecular Function); CD54 (ICAM 1); CD54 Antigens; Capsid; Cell Surface Receptors; Charge; Chemicals; Common Cold; Complex; Computer Analysis; Coxsackie Viruses; Coxsackievirus; Cryo-electron Microscopy; Cryoelectron Microscopy; Dependence; Development; Electron Cryomicroscopy; Entropy; Family Picornaviridae; Free Energy; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Grant; Heating; Human; Human poliovirus; Human, General; Hydration; Hydration status; Hydrogen Oxide; ICAM-1; Intercellular adhesion molecule 1; Investigation; Investigators; Knowledge; Link; Man (Taxonomy); Man, Modern; Methods; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Dynamics Simulation; Molecular Interaction; Mutagenesis; Mutation; Paper; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physical activity; Picornaviridae; Picornaviruses; Polio Virus; Poliovirus; Polioviruses; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Analysis; Proteins; R01 Mechanism; R01 Program; RPG; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Receptor Protein; Receptors, Amino Acid; Receptors, Cell Surface; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rhinovirus; Roentgen Rays; Serotyping; Solutions; Specificity; Structural Protein; Structure; Testing; Thermodynamic; Thermodynamics; Time; Variant; Variation; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; Water; X-Radiation; X-Rays; Xrays; base; coat (nonenveloped virus); computational analysis; computational studies; computer studies; cryoEM; enthalpy; gene product; genome mutation; globular protein; human rhinovirus viral protein 1; insight; large scale simulation; member; molecular dynamics; physical property; poliomyelitis virus; programs; receptor; reconstruction; response; simulation; small molecule; viral protein 1, human rhinovirus; virus protein",Protein Stability and Antiviral Activity in Human Rhinovirus,,39639,MSFB,Macromolecular Structure and Function B Study Section,,13,222160,
7760550,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI039938-13,,NIAID:343035;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PORTLAND,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"CHOU, SUNWEN ;",1877164;,5R01AI039938,05/01/1996,01/31/2014,"1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine; 1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine; 2'-Nor-2'-deoxyguanosine; 2'NDG; 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 5,6-dichloro-2-isopropylamino-1-b-L-ribofuranosyl-1H-benzimidazole; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; Address; Affect; Anti-HIV Therapy; Anti-viral Drug Resistance; Anti-viral Drug Resistant; Antiviral Agents; Antiviral Drug Resistance; Antiviral Drug Resistant; Antiviral Drugs; Antiviral Therapy; Antivirals; Bioavailability; Biologic Availability; Biological Availability; CMV; Cidofovir; Clinical; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Competence; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; DHPG; DNA Polymerases; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Diagnosis; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Resistance, Viral; Drug Targeting; Drug Targetings; Drug resistance; Drugs; EC 2.7; EC 2.7.7.7; Foscarnet; Ganciclovir; Gancyclovir; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Grant; Growth; HCMV; HPMPC; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Inclusion Disease; Kinases; Licensing; Link; Medication; Methods; Mutation; Nordeoxyguanosine; Oral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Phenotype; Phosphinecarboxylic acid, dihydroxy-, oxide; Phosphonoformic Acid; Phosphotransferases; Physiologic Availability; Polymerase Gene; Population; Property; Property, LOINC Axis 2; Recombinants; Reporting; Research Specimen; Resistance; Role; Salivary Gland Virus Disease; Salivary Gland Viruses; Specimen; Tissue Growth; Toxic effect; Toxicities; Transphosphorylases; Transplant Recipients; Transplantation; Validation of Technology; Variant; Variation; Viral; Viral Drug Resistance; Viral Gene Products; Viral Gene Proteins; Viral Proteins; bioavailability of drug; clinical investigation; cytomegalovirus group; design; designing; disease/disorder; drug resistant; drug structure; drug/agent; genome mutation; human cytomegalovirus; immunosuppressed patient; improved; kinase inhibitor; maribavir; ontogeny; phase 3 study; phase 3 trial; phase III trial; protocol, phase III; public health relevance; resistance mechanism; resistance mutation; resistance to Drug; resistance to anti-viral; resistance to antiviral; resistant; resistant mechanism; resistant to Drug; resistant to anti-viral; resistant to antiviral; social role; study, phase III; technology validation; therapy, AIDS anti-HIV; transplant; transplant patient; treatment of viral infectious disease; virus protein",Antiviral Drug Resistance in Human Cytomegalovirus," Relevance CMV disease is a longstanding management problem in immunosuppressed hosts. Characterizing the viral mutations that confer resistance to existing and new antiviral drugs addresses clinically important issues, such as genotypic diagnosis of resistance, cross-resistance and the selection of alternate therapy. To deal with drug resistance and toxicity, new drugs are needed that have different mechanisms of action. Detailed understanding of the genetic mechanisms of resistance will improve the design of suitable new drug structures and antiviral targets.",39938,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,13,343035,
7758805,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI041478-10,,NIAID:243418;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IOWA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"ROLLER, RICHARD J;",1907218;,5R01AI041478,02/01/2006,01/31/2011,"Affinity Chromatography; Binding; Binding (Molecular Function); Biochemical; Capsid; Capsid Proteins; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Charge; Chromatography, Affinity; Coat Proteins; Complex; Funding; Generations; Genetic; Genetics-Mutagenesis; Genome; Goals; HHV-1; HSV; HSV-1; HSV1; Hand; Health; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus hominis; Herpesviruses; Human; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; Human, General; Hybrids; In Vitro; Infection; Laboratories; Libraries; Man (Taxonomy); Man, Modern; Mediating; Membrane; Modeling; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Nuclear Envelope; Nuclear Inner Membrane; Nuclear Lamina; Nuclear Membrane; Nucleocapsid; Nucleus; Play; Process; Production; Proteins; Recruitment Activity; Research; Role; Simplexvirus; Site; Spectrometry; Structure; Subcellular Process; System; System, LOINC Axis 4; Testing; Viral; Viral Coat Proteins; Viral Gene Products; Viral Gene Proteins; Viral Outer Coat Protein; Viral Proteins; Virion; Virus; Virus Particle; Viruses, General; Work; Yeasts; affinity purification; base; coat (nonenveloped virus); experiment; experimental research; experimental study; gene product; herpes simplex i; herpes virus; herpes virus 1, human; herpesvirus; human alphaherpesvirus 1; human herpesvirus 1 group; membrane structure; mutant; prevent; preventing; protein function; reconstitute; reconstitution; recruit; research study; social role; virus protein",UL34 and herpes simplex virus envelopment,,41478,VIRB,Virology - B Study Section,,10,243418,
7760045,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI041637-13,,NIAID:469013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"HAN, JIAHUAI ;",1887131;,5R01AI041637,07/01/1997,01/31/2013,"Address; Animal Welfare; Applications Grants; Bibliography; Biochemical Genetics; Bite; CSBP1; CSBP2; CSPB1; Cell Communication and Signaling; Cell Signaling; Cells; Cellular biology; Characteristics; Cherries; Cherry - dietary; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; DNA Molecular Biology; Data; EXIP; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Enzymes; Equipment; Ethics Committees, Research; Event; Experimental Designs; Family member; Funding; Gene Expression; Genetic, Biochemical; Gram-Negative Bacteria; Grant; Grant Proposals; Grants, Applications; IACUC; INFLM; IRBs; Impact, Environmental; Inflammation; Inflammatory; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Isoforms; Knock-out; Knockout; Knockout Mice; LPS; Lead; Lipids; Lipopolysaccharides; MAPK14; MAPK14 gene; Macrophage Activation; Mammals, Mice; Mice; Mice, Knock-out; Mice, Knockout; Micro RNA; MicroRNAs; Microbe; Molecular; Molecular Biology; Murine; Mus; Mxi2; Null Mouse; PRKM14; PRKM15; Pathway interactions; Pattern; Pb element; Phase; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Protein Isoforms; Proteins; Published Comment; Publishing; Receptor Protein; Regulation; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Role; SAPK2A; Sepsis; Septic Shock; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Study Section; Suggestion; TLR protein; Therapeutic procedure; Toll-like receptors; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; Writing; abstracting; biological signal transduction; bloodstream infection; cell biology; cytokine; experiment; experimental research; experimental study; expiration; gene product; heavy metal Pb; heavy metal lead; human subject; in vivo; innovate; innovation; innovative; insight; macrophage; member; miRNA; microbial; p38; p38 MAPK Gene; p38Alpha; pathway; programs; receptor; research study; response; social role; transcription factor; vertebrata",Cellular Activation Mechanisms in Septic Shock,,41637,IHD,Immunity and Host Defense Study Section,,13,469013,
7758383,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI041644-13,,NIAID:297997;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHARLOTTESVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"BROWN, JAY C.;",1883091;,5R01AI041644,07/01/1997,01/31/2013,"3D image; Address; Adsorption; Animal Welfare; Antiproteases; Assay; Bacteriophages; Bibliography; Bioassay; Biologic Assays; Biological Assay; Burkitt Herpesvirus; Burkitt Lymphoma Virus; CMV; Capsid; Capsid Proteins; Cell Nucleus; Cells; Coat Proteins; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complement; Complement Proteins; Country; Cryo-electron Microscopy; Cryoelectron Microscopy; Cytomegalovirus; DNA; DNA Packaging; DNA analysis; DNA, Viral; Deoxyribonucleic Acid; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E-B Virus; EB virus; EBV; Ecological impact; Editorial Comment; Editorial Comment (PT); Electron Cryomicroscopy; Electron Microscopy; Electrons; Endopeptidase Inhibitors; Environment; Environmental Impact; Epstein Barr Virus; Epstein-Barr Virus; Equipment; Ethics Committees, Research; HCMV; HHV-1; HHV-4; HHV-8; HHV8; HSV; HSV-1; HSV1; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesvirus hominis; Herpesviruses; Heterogeneity; Human Herpesvirus 4; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; IACUC; IRBs; Image Reconstructions; Images, 3-D; Impact, Environmental; In Vitro; Individual; Infection; Infectious Mononucleosis Virus; Institutional Animal Care and Use Committee; Institutional Review Boards; International; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Laboratories; Membrane; Microscopic; Nature; Negative Beta Particle; Negatrons; Nuclear Pore; Nucleus; Organelles; Paper; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Phages; Plastics; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protease Antagonists; Protease Inhibitor; Protein Binding; Protein Cleavage; Proteinase Inhibitors; Proteins; Proteolysis; Published Comment; Reconstructions, Image; Research; Research Design; Research Ethics Committees; Research Resources; Resolution; Resources; Role; Salivary Gland Viruses; Scaffolding Protein; Simplexvirus; Structural Protein; Structure; Study Type; Surface; System; System, LOINC Axis 4; Testing; Therapeutic; Three-Dimensional Image; Tripcellim; Trypsin; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral Coat Proteins; Viral Outer Coat Protein; Virus; Virus-HHV8; Viruses, General; Visual; abstracting; bacterial virus; base; coat (nonenveloped virus); cryoEM; cytomegalovirus group; design; designing; experiment; experimental research; experimental study; expiration; gene product; herpes simplex i; herpes virus; herpes virus 1, human; herpesvirus; human alphaherpesvirus 1; human cytomegalovirus; human herpesvirus 1 group; human herpesvirus 4 group; human herpesvirus 8; human subject; in vivo; membrane structure; new therapeutic target; particle; polypeptide; programs; reconstruction; research study; response; social role; study design; vertebrata; viral DNA; virus DNA",Assembly of the Herpes Simplex Virus Capsid,,41644,VIRA,Virology - A Study Section,,13,297997,
7758185,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI042075-10,,NIAID:200865;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,FORT WORTH,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,110091808,US,TX,761072699,UNIVERSITY OF NORTH TEXAS HLTH SCI CTR,"SIMECKA, JERRY W;",1888430;,5R01AI042075,07/01/1999,01/31/2011,"Address; Adoptive Cell Transfers; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibodies; Antiinflammatories; Antiinflammatory Agents; Athymic Nude Mouse; Award; CD25; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; Cell Line; Cell Lines, Strains; Cell Transfers, Adoptive; CellLine; Cells; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Data; Development; Disease; Disease Progression; Disorder; Eaton Agent; Eaton Liu agent; Eperythrozoon; Experimental Designs; Funding; Generations; Haemobartonella; Human; Human, General; IL-10; IL10; IL10A; IL2R; IL2RA; IL2RA gene; INFLM; ITX; Immune; Immune response; Immunity; Immunization; Immunologic Stimulation; Immunologic, Immunochemical; Immunological Stimulation; Immunologically Directed Therapy; Immunologics; Immunostimulation; Immunotherapy; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Interleukin 10 Precursor; Interleukin-10; Knockout Mice; LYT3; Lesion; Lung; Lung diseases; M. pneumoniae; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Modeling; Murine; Mus; Mycoplasma; Mycoplasma Infections; Mycoplasma pneumoniae; Mycoplasma pulmonis; Normal Cell; Nude Mice; Null Mouse; Outcome; Pathogenesis; Play; Population; Predisposition; Process; Publishing; Pulmonary Body System; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Organ System; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Role; Sensitization, Immunologic; Sensitization, Immunological; Severities; Susceptibility; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; TCGFR; Th-1 Cell; Th1 Cells; Thymus-Dependent Lymphocytes; Tracts, Respiratory; Type 1 Helper Cell; Work; cell type; cultured cell line; cytokine; disease/disorder; host response; immune therapy; immunoresponse; in vivo; lung disorder; new approaches; novel approaches; novel strategies; novel strategy; pathogen; pulmonary; resistant; respiratory tract; response; social role; thymus derived lymphocyte",T cell subsets in murine mycoplasma respiratory disease,,42075,ZRG1,Special Emphasis Panel,,10,200865,
7756579,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI042370-13,,NIAID:389813;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"REINER, STEVEN L;",1868059;,5R01AI042370,12/01/1997,01/31/2013,"Acute; Address; Adopted; Animal Welfare; Antibodies; Attention; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BALB/c; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bibliography; Binetrakin; Biological; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD54 (ICAM 1); CD54 Antigens; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell division; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communities; Country; D2 receptor; DRD2; DRD2 Receptor; Data; Daughter; Defense Mechanisms; Distal; Dopamine D2 Receptor; Ecological impact; Editorial Comment; Editorial Comment (PT); Effector Cell; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Figs; Figs - dietary; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Helminths; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hereditary; Heterogeneity; IACUC; ICAM-1; IL-4; IL4; IL4 Protein; IRBs; Immune response; Immunity; Immunologic Memory; Immunological Memory; Impact, Environmental; Inbred BALB C Mice; Incidence; Inducer Cells; Infection; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercellular adhesion molecule 1; Interleukin-4; Interleukin-4 Precursor; International; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; Leishmania; Leishmania (Leishmania) major; Leishmania (genus); Leishmania major; Leishmania tropica major; Leishmaniasis; Lymphocyte; Lymphocyte Stimulatory Factor 1; Lymphocytic; MCGF-2; Mammals, Mice; Mast Cell Growth Factor-2; Memory; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microbe; Modeling; Mouse, BALB C; Murine; Mus; Natural regeneration; Nature; Organism; Parasites; Parasitic infection; Pattern; Phase; Physiologic; Physiological; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Published Comment; Qualifying; Racial Segregation; Receptor Protein; Regeneration; Regulatory Element; RegulatoryElement; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Sorting - Cell Movement; Specificity; Subcellular Process; Suggestion; System; System, LOINC Axis 4; T cell regulation; T-Cell Growth Factor 2; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T. gondii infection; T4 Cells; T4 Lymphocytes; T8 Cells; T8 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Toxoplasma gondii Infection; Toxoplasmosis; Transgenic Mice; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; Worms, Parasitic; abstracting; anamnestic reaction; base; biological signal transduction; cytokine; daughter cell; design; designing; experiment; experimental research; experimental study; expiration; extracellular; gene product; helper T cell; host response; human subject; immunoresponse; insight; living system; lymph cell; mutant; novel; pathogen; polypeptide; programs; psychological defense mechanism; receptor; regenerate; regenerative; research study; response; secondary immune response; segregation; sorting; theories; thymus derived lymphocyte; vertebrata; willingness",Helper T Cell Regulation In Murine Leishmaniasis,,42370,PTHE,Pathogenic Eukaryotes Study Section,,13,389813,
7751821,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI042738-13,,NIAID:443085;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WALSH, CHRISTOPHER T;",6970323;,5R01AI042738,02/01/1998,01/31/2012,"1,2-benzenediol; 1,2-dihydroxybenzene; 2-hydroxyphenol; 4-Oxazolecarboxamide, 2-(2,3-dihydroxyphenyl)-4,5-dihydro-N-hydroxy-N-02-(1H-imidazol-4-yl)ethyl)-5-methyl-, cis-(-)-; Acid-Amino-Acid Ligases; Acinetobacter; Bacteria; Benzamide, N,N',N''-(2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl)tris(2,3-dihydroxy-, (3S-(3R*,7R*,11R*)))-; Binding; Binding (Molecular Function); Catechols; Coliform Bacilli; Cyclization; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Enterobactin; Enterochelin; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Evaluation; Extraribosomal Peptide Biosynthesis; FLR; Failure (biologic function); Fe element; Foundations; Gene Cluster; GeneHomolog; Genes; Homolog; Homologous Gene; Homologue; Human; Human, General; Iron; Iron Chelates; Iron Chelating Agents; Ligase; Man (Taxonomy); Man, Modern; Molecular Interaction; Nonribosomal Peptide Biosynthesis; Nucleic Acid-Independent Peptide Biosynthesis; Pathogenicity; Peptide Biosynthesis, Extra-Ribosomal; Peptide Biosynthesis, Non-Ribosomal; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthetases; Physical condensation; Production; Proteins; Pyrocatechols; Role; S. typhi; S. typhosa; S.Typhi; Salmonella enterica serovar Typhi; Salmonella typhi; Salmonella typhosa; Siderochromes; Siderophores; Synthetases; Time; Virulence; acid aminoacid ligase; acinetobactin; condensation; failure; gene product; hydroxamate; microcin; o-Dihydroxybenzenes; ortho-Dihydroxybenzenes; pathogen; peptide synthase; respiratory; scaffold; scaffolding; social role; uptake",Acinetobactin and C-Glucosylated Enterobactin Siderophores,,42738,MSFA,Macromolecular Structure and Function A Study Section,,13,443085,
7761248,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI043222-12,,NIAID:284130;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"SILICIANO, ROBERT F;",1884579;,5R01AI043222,04/01/1998,01/31/2014,"2-Propylpentanoic Acid; 5-hydroxy-1,4- naphthalenedione; 5-hydroxy-1,4-naphthoquinone; 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Affect; Animal Model; Animal Models and Related Studies; Antiretroviral Therapy, Highly Active; Antiviral Agents; Antiviral Drugs; Antivirals; Area; Biological Models; C-terminal; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Line; Cell Lines, Strains; Cell model; CellLine; Cells; Cells, CD4; Cellular model; Chromatin Structure; Clinical; Co-Stimulator; Costimulator; DNA-Dependent RNA Polymerase II; Depakote; Depakote ER; Divalproex; Drug Evaluation, Preclinical; Drug Screening; Drugs; Epidermal Thymocyte Activating Factor; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Frequencies (time pattern); Frequency; Funding; Gene Expression; Genes; Genetic; Genome; HAART; HIV; HIV Infections; HIV-1; HIV-I; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; IL-2; IL-7; IL2; IL2 Protein; IL7 Protein; Immunodeficiency Virus Type 1, Human; In Vitro; Individual; Infection; Interleukin 2; Interleukin 2 Precursor; Interleukin 7 Precursor; Interleukin II; Interleukin-2; Interleukin-7; Interleukine 2; Interleukine 2 Precursor; Interleukine II; LAV-HTLV-III; Libraries; Lymphadenopathy-Associated Virus; Lymphocyte Mitogenic Factor; Lymphopoietin-1; Maintenance; Maintenances; Medication; Mitogenic Factor; Model System; Modeling; Models, Biologic; Molecular; Nature; PPIase; Patients; Pentanoic acid, 2-propyl-; Peptidyl-Prolyl cis-trans-Isomerase; Peptidylproline cis-trans-isomerase; Peptidylprolyl Isomerase; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Preclinical Drug Evaluation; Proline Isomerase; Proline Rotamase; Prolyl Isomerase; Protein Phosphorylation; RNA Polymerase B; RNA Polymerase II; Regimen; Relative; Relative (related person); Rest; Site; System; System, LOINC Axis 4; T cell growth factor; T-Cell Activation; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; TSA antibioitc; Testing; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Trichostatin A; Valproic Acid; Viral; Virus; Virus-HIV; Viruses, General; anti-retroviral therapy, highly active; comparative; cultured cell line; cyclophilin; design; designing; drug/agent; efficacy evaluation; helper T cell; human T cell leukemia virus III; human T lymphotropic virus III; immunophilin; interest; juglone; model organism; new approaches; novel; novel approaches; novel strategies; novel strategy; prostratin; public health relevance; small molecule; small molecule libraries; thymus derived lymphocyte; tricostatin A",Latent Viral Reservoirs in HIV 1 Infection, HIV can persist in a silent or latent form even in patients who are treated with potent antiviral drugs. Curing HIV infection will require new ways to eliminate this latent reservoir. The studies proposed here are designed to find new drugs that can eliminate this latent reservoir.,43222,ADDT,AIDS Discovery and Development of Therapeutics Study Section,,12,284130,
7754422,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI044033-10,,NIAID:285737;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCKVILLE,UNITED STATES,,08,144676566,US,MD,20852,HENRY M. JACKSON FDN FOR THE ADV MIL/MED,"MAURELLI, ANTHONY T;",1886230;,5R01AI044033,12/01/1998,01/31/2011,"Acute; Address; Animals; Bacteria; Biochemical; Biology; Blindness; Cannot achieve a pregnancy; Cellular biology; Cervicitis; Chlamydia; Chronic Disease; Chronic Illness; Communities; Complex; Coronary Disease; Coronary heart disease; DNA; Data; Deoxyribonucleic Acid; Development; Difficulty conceiving; Disease; Disorder; EC 2.1.1; Endocarditis; Epididymitis; Female; Generalized Growth; Genes; Genetic; Genetic Transformation; Genetic analyses; Goals; Growth; Infertility; Knowledge; Laboratories; Learning; Life Style; Lifestyle; Maintenance; Maintenances; Methods; Methods and Techniques; Methods, Other; Methyltransferase; Miyagawanella; Molecular Genetic; Molecular Genetics; Murein; Non-Gonococcal Urethritis; Nonspecific urethritis; Organism; Pathogenesis; Pathogenicity; Pathway interactions; Pelvic Inflammatory Disease; Peptidoglycan; Pneumonia; Pneumonitis; Polyarthritides; Pulmonary Inflammation; Research; STD; Salpingitis; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Source; System; System, LOINC Axis 4; Techniques; Tissue Growth; Transformation, Genetic; Venereal Diseases; Venereal Disorders; Venereal Infections; Work; bedsonia; cell biology; chronic disease/disorder; chronic disorder; cofactor; coronary disorder; disease/disorder; gene replacement; genetic analysis; infertile; interest; living system; male; man; man's; methylase; mutant; new technology; ontogeny; pathogen; pathway; success; tool; tool development; transmethylase; unable to bear children; uptake; vaccine development",Molecular Genetic Analysis of Chlamydia Pathogenicity,,44033,BACP,Bacterial Pathogenesis Study Section,,10,285737,
7754872,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI044212-10,,NIAID:278999;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ANN ARBOR,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"SWANSON, MICHELE SOMES;",1868118;,5R01AI044212,06/01/1999,01/31/2011,"Adherence; Adherence (attribute); Algorithms; Amoeba; Amoeba genus; Assay; Bacteria; Base Sequence; Binding Sites; Bio-Informatics; Bioassay; Biochemical; Biochemical Pathway; Bioinformatics; Biologic Assays; Biological Assay; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chlamydia; Combining Site; Coxiella; Dot Immunoblotting; Enabling Factors; Engineering; Engineerings; Environment; Experimental Models; Experimental Models, Other; Expression Profiling; Expression Signature; Factors, Enabling; Francisella; Gene Products, RNA; Genes; Genetic; Genome; Genomics; Genus Mycobacterium; Goals; Human; Human, General; Hydrogen Oxide; Immunoblotting, Dot; Intracellular Communication and Signaling; Knowledge; L-Threonine; Life; Life Cycle; Life Cycle Stages; Lung; Lytotoxicity; Man (Taxonomy); Man, Modern; Mediating; Metabolic Networks; Microarray Analysis; Microarray-Based Analysis; Microbe; Microorganisms, General; Miyagawanella; Models, Experimental; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Motility; Motility, Cellular; Mycobacterium; Nucleotide Sequence; Opportunistic Infections; Paris; Paris, France; Pathogenesis; Pathway interactions; Pattern; Phagocytes; Phagocytic Cell; Phagosomes; Phase; Phenotype; Philadelphia; Physiology; Pigments; Production; RNA; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Reactive Site; Regulation; Regulon; Research; Resistance; Respiratory System, Lung; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Sigma Element; Sigma Factor; Sigma Initiation Factor; Sigma Subunit; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stress; System; System, LOINC Axis 4; Testing; Threonine; Transmission; Vacuole; Virulence; Virulent; Water; Water Supply; amebocyte; bedsonia; biological signal transduction; cell motility; cytotoxicity; design; designing; dot blotting; genome sequencing; lens; life course; macrophage; member; microarray technology; microbial; microorganism; molecuar profile; molecular signature; mutant; novel; nucleic acid sequence; pathogen; pathway; pulmonary; resistant; reverse transcriptase PCR; trafficking; trait; transmission process",Analysis of L. Pneumophilia Virulence Regulation,,44212,BACP,Bacterial Pathogenesis Study Section,,10,278999,
7763802,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI044458-11,,NIAID:358875;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"CORBETT, JOHN A;",1885235;,5R01AI044458,02/01/2008,01/31/2013,"5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1[{..}]1); ATGN; Address; Animal Model; Animal Models and Related Studies; Animal Welfare; Anti-Viral Response; Antigens; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Apoptosis; Apoptosis Pathway; Autoimmune Diseases; B9 endocrine pancreas; Beta Cell; Bibliography; Biochemical; Biological Models; COX-2; COX2; Catabolin Gene; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Cessation of life; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Country; Death; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Dose; Double-Stranded RNA; EMC virus; EMCV; Ecological impact; Editorial Comment; Editorial Comment (PT); Encephalomyocarditis virus; Endocrine; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Gene Expression; Gene Products, RNA; Genes; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genome; Goals; Human; Human, General; Humulin R; IACUC; IDD; IDDM; IFN; IL-1; IL-1 Gene; IL1; IL1-Beta Gene; IL1B gene; IL1F2 Gene; INFLM; IRBs; Impact, Environmental; Infection; Inflammation; Inflammatory; Inflammatory Response; Inherited Predisposition; Inherited Susceptibility; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Interferons; Interleukin 1 Gene; Interleukin 1, Beta Proprotein Gene; Interleukin I; Interleukin-1; Interleukin-1-Beta Gene; International; Islands of Langerhans; Islet Cells; Islets of Langerhans; Lead; Lymphocyte; Lymphocyte-Stimulating Hormone; Lymphocytic; Macrophage Activation; Macrophage Cell Factor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Model System; Models, Biologic; Molecular; Mononitrogen Monoxide; Murine; Mus; Necrosis; Necrotic; Nesidioblasts; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Novolin R; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Pb element; Poly I-C; Poly(I).poly(C); Poly(rI).Poly(rC); Polyinosinic acid[{..}]polycytidylic acid; Polyinosinic-Polycytidylic Acid; Polyribose Inosin-Cytidil; Preinterleukin 1 Beta Gene; Prevention; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Published Comment; RNA; RNA Viruses; RNA, Double-Stranded; RNA, Non-Polyadenylated; Rat; Rattus; Receptor Protein; Receptor Signaling; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Ribonucleic Acid; Signal Pathway; Source; Stimulus; Structure; Subcellular Process; Suggestion; T Helper Factor; T1 diabetes; T1D; T1DM; Techniques; Testing; Therapeutic; Transgenic Organisms; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Translations; Type 1 diabetes; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; abstracting; autoimmune disorder; base; beta cell development; cell damage; cell injury; cytokine; design; designing; diabetes; disease/disorder; dsRNA; endocrine pancreas; endocrine pancreas development; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; expiration; genetic etiology; genetic mechanism of disease; genetic vulnerability; hCOX-2; heavy metal Pb; heavy metal lead; human disease; human subject; immunogen; insight; insulin dependent diabetes; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; language translation; lymph cell; lymphocyte activating factor; macrophage; model organism; necrocytosis; novel; pathway; poly IC; polyinosate.polycytidylate; programs; receptor; research study; response; transgenic; translation research enterprise; type I diabetes; vertebrata; viral infection; virus infection",Mechanisms of Viral-Induced Beta Cell Damage,,44458,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,11,358875,
7754699,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI044923-10,,NIAID:360708;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MIAMI,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"ADKINS, REBECCA D;",1899163;,5R01AI044923,07/01/2000,01/31/2011,"21+ years old; 5-Isothiocyanatofluorescein; ATGN; Address; Adult; Age; Allergens; Allergy; Antigens; Asthma; Bronchial Asthma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cells; Cells, CD4; Cellular Regulation; Childhood; Chromatin; Developed Countries; Developed Nations; Development; Disease; Disorder; Emigrant; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equilibrium; Event; FITC; Fluorescein-5-isothiocyanate; Frequencies (time pattern); Frequency; Generations; Goals; Health; Hematopoietic; Human; Human, Adult; Human, General; Hypersensitivity; Immune system; Immunity; Industrialized Countries; Industrialized Nations; Infant; Injection of therapeutic agent; Injections; Laboratories; Life; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Methylation; Mice; Molecular; Murine; Mus; Neonatal; Nucleic Acid Regulatory Sequences; Pathology; Pattern; Peripheral; Plastics; Population; Process; Protein Methylation; Regimen; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Relative; Relative (related person); Source; Specificity; T4 Cells; T4 Lymphocytes; Testing; Th-2 Cell; Th2 Cells; Type 2 Helper Cell; adult human (21+); balance; balance function; base; body system, allergic/immunologic; cell growth regulation; cell type; cytokine; demethylation; design; designing; disease/disorder; fetal; genetic regulatory element; helper T cell; immunogen; improved; in vivo; insight; neonate; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pediatric; prevent; preventing; response; thymocyte",Regulation of murine neonatal Th2 function,,44923,CMI,Cellular and Molecular Immunology - A,,10,360708,
7755018,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI044941-10,,NIAID:286680;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,EVANSTON,UNITED STATES,,09,154538107,US,IL,602013137,NORTHSHORE UNIV HEALTHSYSTEM RES INST,"FROELICH, CHRISTOPHER JOHN;",1948316;,5R01AI044941,06/01/2000,01/31/2011,"Affinity; Apoptosis; Apoptosis Pathway; Autoregulation; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Binding Sites; Biological; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CTL; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell membrane; Cell surface; Cell-Death Protease; Cell-Mediated Lympholytic Cells; Cells; Cessation of life; Chondroitin Sulfates; Chondroitin, hydrogen sulfate; Combining Site; Complex; Cytolytic T-Cell; Cytoplasmic Granules; Cytoplasmic Membrane; Cytosol; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; Data; Death; Detection; Diffuse; Disease; Disorder; Electrostatics; Endosomes; Ensure; Esteroproteases; Event; Genetic Alteration; Genetic Change; Genetic defect; Glycobiology; Granzyme; Homeostasis; Host Defense; ICE-like protease; Image; Imaging Procedures; Imaging Techniques; Immune; Inorganic Sulfates; Intracellular Communication and Signaling; Investigators; K lymphocyte; Learning; Left; Mediating; Membrane; Methods; Modeling; Molecular; Molecular Analysis; Molecular Interaction; Mutation; NK Cells; Natural Killer Cells; Outcome; PSGAG; Pathway interactions; Peptidases; Peptide Hydrolases; Physiological Homeostasis; Plasma Membrane; Play; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteoglycan; Proteolytic Enzymes; Raja; Reactive Site; Receptor Protein; Receptosomes; Research Personnel; Researchers; Role; Scheme; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; T-Lymphocyte and NK-Cell; T-Lymphocyte and Natural Killer Cell; T-Lymphocytes, Cytotoxic; Technics, Imaging; Testing; Tumor Cell; Unspecified or Sulfate Ion Sulfates; VESCL; Vesicle; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; Work; Wound Healing; Wound Repair; autoreactivity; biological signal transduction; caspase; cystein protease; cystein proteinase; cysteine endopeptidase; cytolysin; cytotoxic serine protease B; disease/disorder; expectation; fragmentin 2; gene product; genome mutation; glycosaminoglycan polysulfate; glycosaminoglycan polysulfuric acid ester; glycosaminoglycan polysulphate; granule; granzyme B; imaging; in vivo; lymphocyte pore-forming protein; membrane structure; monomer; necrocytosis; neoplastic cell; pathway; perforin; plasmalemma; polymerization; polysulfated glycosaminoglycan; pore forming protein; porin; programs; receptor; response; serglycin; social role; sulfate; sulfated glycosaminoglycan; tissue repair; trafficking; uptake; virus protein",Molecular Mechanism of Granule-mediated Apoptosis,,44941,CMI,Cellular and Molecular Immunology - A,,10,286680,
7753849,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI045459-10,,NIAID:391357;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"PIROFSKI, LIISE-ANNE ;",1868151;,5R01AI045459,07/01/2000,01/31/2011,"0-11 years old; 21+ years old; AIDS; Ab-mediated protection; Abbreviations; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adult; Antibiotic Resistance; Antibodies; Antibody-mediated protection; Antiretroviral Therapy, Highly Active; B blood cells; B-Cells; B-Lymphocytes; Bacteremia; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Mediated Immunology; Cell Wall; Cell-Mediated Immunity; Cells, CD4; Cellular Immunity; Characteristics; Child; Child Youth; Children (0-21); Conflict; Conflict (Psychology); D. pneumoniae; D.pneumoniae; Data; Defect; Dependency; Dependency (Psychology); Diplococcus pneumoniae; Drug resistance; Effector Cell; Family; Funding; Future; Gamma Globulin, 19S; Gene Family; Generations; Genes; Genes, Ig; Genes, Immunoglobulin; Glycans; HAART; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; Heterophil Granulocyte; Highly Active Antiretroviral Therapy; Human; Human, Adult; Human, Child; Human, General; IgM; Immune; Immune response; Immunity; Immunity, Cellular; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunoglobulin Genes; Immunoglobulin M; Immunoglobulin V; Immunoglobulin Variable Region; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; In Vitro; Individual; Inflammatory; Inflammatory Response; Killings; Knockout Mice; Knowledge; LYT3; Laboratories; Licensing; Light; Link; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Moab, Clinical Treatment; Monoclonal Antibodies; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouse Strains; Murine; Mus; Nature; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Patients; Persons; Photoradiation; Pneumococcal Infections; Pneumococcal Pneumonia; Pneumococcal conjugate vaccine; Pneumococcal vaccine; Pneumococcus; Pneumonia; Pneumonia, Lobar; Pneumonia, Pneumococcal; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Polysaccharides; Prevalence; Programs (PT); Programs [Publication Type]; Pulmonary Inflammation; Research; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Respiratory System, Lung; S. pneumoniae; Sepsis; Serotyping; Streptococcus pneumoniae; Streptococcus pneumoniae Infections; Streptococcus pneumoniae plY protein; Streptococcus pneumoniae vaccine; Systemic disease; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Translating; Translatings; Vaccinated; Vaccination; Vaccines; Variable Region; Variable Region, Ig; adult human (21+); anti-retroviral therapy, highly active; antibiotic resistant; bacteraemia; base; bloodstream infection; children; cohort; cytokine; defined contribution; drug resistant; emotional dependency; helper T cell; host response; immunoresponse; immunosuppressed patient; improved; intraperitoneal; language translation; mimetics; neutrophil; plY protein, Streptococcus pneumoniae; pneumococcal disease; pneumococcus infection; pneumolysin; programs; pulmonary; resistance to Drug; resistant to Drug; response; secretory IgM; senescence; thymus derived lymphocyte; vaccine efficacy; youngster",Variable Gene Use and Pneumococcal Immunity in AIDS,,45459,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,10,391357,
7758339,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI045658-08,,NIAID:380993;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"MCDONOUGH, KATHLEEN A.;",1888168;,5R01AI045658,07/01/2000,01/31/2013,"5' Untranslated Regions; 5'UTR; Address; Animal Welfare; Animals; Area; Assay; Bacillus; Bacillus (bacterium); Bibliography; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Budgets; CO2; Carbon Dioxide; Carbonic Anhydride; Combining Site; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Cues; DISSEC; DNA-Binding Proteins; Data; Decision Making; Diagnostic; Disease; Disorder; Dissection; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Funding; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Generalized Growth; Genes; Genes, LacZ; Genes, Regulator; Genetic; Genetic Screening; Genetics-Mutagenesis; Growth; Health; Hypoxia; Hypoxic; IACUC; IRBs; Impact, Environmental; In Vitro; Individual; Infection; Institutes; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Intervention; Intervention Strategies; Knowledge; LacZ; LacZ Genes; Light; Lipids; M. tb; M. tuberculosis; M.tb; M.tuberculosis; METBL; Metabolic Processes; Metabolism; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Molecular Interaction; Molecules, Repressor; Mutagenesis; Mycobacterium tuberculosis; Nature; Oxygen Deficiency; Pathogenesis; Phenotype; Photoradiation; Policies; Postdoc; Postdoctoral Fellow; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Published Comment; RNA; RNA, Non-Polyadenylated; Reactive Site; Recovery; Regulation; Regulator Genes; Regulatory Pathway; Reporter; Repression; Repressor Molecules; Research; Research Associate; Research Ethics Committees; Research Resources; Resources; Ribonucleic Acid; Role; Salaries; Students; System; System, LOINC Axis 4; TB vaccine; Therapeutic; Tissue Growth; Transcriptional Regulatory Elements; Tuberculosis; Tuberculosis Vaccines; UTRs; Uncertainty; Untranslated Regions; Variant; Variation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Virulence; Wages; Work; abstracting; anti-TB vaccine; cost; disease/disorder; disseminated TB; disseminated tuberculosis; doubt; experience; expiration; flexibility; gene function; gene product; human subject; in vivo; in vivo Model; interdisciplinary approach; interventional strategy; latent infection; mRNA Leader Sequences; macrophage; men; men's; ontogeny; post-doc; post-doctoral; prevent; preventing; programs; regulatory gene; response; social role; trans acting element; tuberculous spondyloarthropathy; vertebrata",Gene expression in M. tuberculosis,,45658,ZRG1,Special Emphasis Panel,,8,380993,
7766978,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI045746-10,,NIAID:346916;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"CAMILLI, ANDREW ;",1927842;,5R01AI045746,03/01/2000,02/28/2011,"Address; Algae, Blue-Green; Amino Acids; Bacteria; Binding; Binding (Molecular Function); Biochemical; Biochemical Genetics; Biological Models; Biology; Blue-Green Bacteria; Camping; Categories; Cell Communication and Signaling; Cell Signaling; Cellulose; Chitin; Cholera; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Code; Coding System; Cyanobacterium; Cyanophyceae; Cyanophyta; DNA Binding; DNA Binding Interaction; EC 2.7; Environment; Funding; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Transcription; Genetic, Biochemical; Genome; Goals; Grant; Growth; Human; Human Figure; Human body; Human, General; Hydrogen Oxide; Hydrolysis; Infection; Intestinal; Intestines; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Kinases; Knowledge; Life; Ligand Binding; Man (Taxonomy); Man, Modern; Mediating; Medical; Microbial Biofilms; Model System; Modeling; Models, Biologic; Molecular Interaction; Molecular Target; NIAID; National Institute of Allergy and Infectious Disease; Nutrient; Organism; PDE; Pathogenicity; Peptide Domain; Periplasmic Space; Phosphodiesterases; Phosphorylation; Phosphotransferases; Physiology; Play; Polyanhydroglucuronic Acid; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Domains; Protein Phosphorylation; Proteins; RNA; RNA Expression; RNA, Non-Polyadenylated; Radiolabeled; Regulation; Regulatory Pathway; Research Personnel; Researchers; Ribonucleic Acid; Role; Second Messenger Systems; Second Messengers; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; System; System, LOINC Axis 4; Tertiary Protein Structure; Testing; Tissue Growth; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transphosphorylases; V. cholerae; V.cholerae; Vibrio cholerae; Vibrio comma; Virulence; Water; Work; alpha-Cellulose; aminoacid; biofilm; biological signal transduction; bowel; combat; experience; gene product; living system; ontogeny; pathogen; periplasm; periplasmic; phosphoric diester hydrolase; programs; radiolabel; radiotracer; response; second messenger; sensor; social role; tool",Role of c-diGMP signaling in Vibrio cholerae virulence,,45746,BACP,Bacterial Pathogenesis Study Section,,10,346916,
7758313,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI045846-10,,NIAID:361298;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"VON BOEHMER, HARALD ;",3134449;,5R01AI045846,06/15/2000,01/31/2011,"ATGN; Address; Antigen Receptors; Antigens; Arm; Binding; Binding (Molecular Function); CD74 antigen; CD8; CD8B; CD8B1; CD8B1 gene; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cells; Class I Antigens; Class I Major Histocompatibility Antigens; Class II Antigens; Class II Major Histocompatibility Antigens; Complex Class 1; Complication; DNA Sequence Rearrangement; Data; Development; Exhibits; Gene Expression; Generations; Genes, Class I; Genes, MHC Class I; Genome Instability; Genomic Instability; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; I-A Antigen; Ia Antigens; Ia associated invariant chain; Ia-Like Antigens; Immune Response Antigens; Immune system; Immune-Response-Associated Antigens; In Vitro; Intracellular Communication and Signaling; K Cells; Killer Cells; LYT3; Leukemia, T-Cell; Ligands; Lymphocytic Leukemia, T-Cell; MHC Class I; MHC Class I Genes; MHC Class I Molecule; MHC Class I Protein; MHC Class II Molecule; MHC Class II Protein; MHC Receptor; MHC class I antigen; MHC class II antigen; Major Histocompatibility Complex Class 1; Major Histocompatibility Complex Class II; Major Histocompatibility Complex Receptor; Molecular Interaction; Phase; Phenotype; Physiologic; Physiological; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rearrangement; Receptor Gene; Receptor Protein; Receptor Signaling; Receptors, Antigen; Receptors, Antigen, T-Cell; Reporting; Research Resources; Resources; Reticuloendothelial System, Thymus; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Staging; Surface; T-Cell Antigen Receptor Specificity; T-Cell Development; T-Cell Leukemia; T-Cell Ontogeny; T-Cell Receptor; T-Cell Receptor Specificity; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocytic Leukemia; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Transgenes; Upper arm; biological signal transduction; body system, allergic/immunologic; class II associated invariant chain; experience; experiment; experimental research; experimental study; immunogen; in vivo; interest; invariant chain; notch; notch protein; notch receptors; organ system, allergic/immunologic; receptor; receptor expression; research study; social role; thymus derived lymphocyte",Role of the pre-T cell receptor in lineage commitment,,45846,CMIB,Cellular and Molecular Immunology - B Study Section,,10,361298,
7754416,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI045999-10,,NIAID:364245;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"VINETZ, JOSEPH M.;",1949775;,5R01AI045999,04/01/2000,01/31/2011,"Anopheles; Anopheles Genus; Antibodies; Area; Aspartic Endopeptidases; Aspartic Proteinases; Aspartyl Proteases; Aspartyl Proteinases; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Models; Biological Process; Biology; Carboxyl (Acid) Proteinases; Carboxylic Proteinases; Cell surface; Cellular biology; Chitin; Chitinase; Complex; Culicidae; Digestion; Drug resistance; Enzymes; Esteroproteases; Fertilized Egg; Fertilized Ovums; Food; Gene Deletion; Gene Expression; Goals; Hemoglobin; Homo; Human; Human, General; Immunoelectron Microscopy; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Invaded; Investigation; Investigators; Kinetic; Kinetics; Lectin; Light; Malaria; Man (Taxonomy); Man, Modern; Mediating; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Midgut; Moab, Clinical Treatment; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Molecular Target; Molecular Weight; Monoclonal Antibodies; Mosquitoes; Ortholog; Orthologous Gene; Ovum, Fertilized; Paludism; Parasites; Penetration; Peptidases; Peptide Hydrolases; Photoradiation; Plasmodium; Plasmodium Infections; Plasmodium aspartic proteinase G; Plasmodium falciparum; Play; Poly(1,4-(N-acetyl-beta-D-glucosaminide)) glycanohydrolase; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Public Health; Research; Research Personnel; Researchers; Role; Series; Site; Staging; Structure of zygote; Testing; Transmission; Vaccines; Vacuole; Work; Zygote; aspartate protease; aspartic hemoglobinase; aspartic hemoglobinase I; aspartic protease; base; cell biology; drug resistant; experiment; experimental research; experimental study; gene deletion mutation; gene product; insight; knockout gene; new approaches; novel; novel approaches; novel strategies; novel strategy; plasmepsin; plasmepsin I; plasmepsin protease; prevent; preventing; programs; public health medicine (field); research study; resistance to Drug; resistant to Drug; social role; tandem mass spectrometry; transmission process; vector; vector mosquito; zygote",Molecular Targets of Blocking Malaria Transmission,,45999,ZRG1,Special Emphasis Panel,,10,364245,
7758327,R01,AI,5,,02/01/2010,01/31/2011,PA-99-067,5R01AI046221-09,,NIAID:366601;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,073271827,US,NY,10065,NEW YORK BLOOD CENTER,"JIANG, SHIBO ;",2103422;,5R01AI046221,04/01/2000,01/31/2011,"AIDS; AIDS Drugs; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affinity; Anti-AIDS Agents; Anti-AIDS Drugs; Anti-HIV Agents; Anti-HIV Drugs; Anti-Human Immunodeficiency Virus Agents; Anti-Retroviral Agents; Antiproteases; Antiretroviral Agents; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; C-C CKR-5 Gene; C-C Chemokine Receptor Type 5 Gene; C-Peptide; C-terminal; CC-CKR-5 Gene; CCCKR5 Gene; CCR-5 Gene; CCR5; CCR5 gene; CD195 Antigen Gene; CHEMR13 Gene; CKR-5 Gene; CKR5 Gene; CMKBR5 Gene; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Cell Surface Glycoproteins; Cell fusion; Cell membrane; Cells; Chemokine (C-C) Receptor 5 Gene; Clinic; Clinical Trials; Clinical Trials, Unspecified; Combining Site; Connecting Peptide; Crystallographies; Crystallography; Cytoplasmic Membrane; D2S201E; Data; Development; Drug Design; Drug resistance; Drugs; Drugs, Nonproprietary; Endopeptidase Inhibitors; Envelope Glycoprotein gp120, HIV; FB22; Funding; Fuzeon; Generic Drugs; Genotype; Goals; HIV; HIV Cell Fusion Inhibitors; HIV Envelope Protein gp120; HIV Fusion Inhibitors; HIV Infections; HIV-1; HIV-1 Fusion Co-Receptor Gene; HIV-I; HIV/AIDS; HIV/AIDS problem; HIV1; HM89; HSY3RR; HTLV-III; HTLV-III Infections; HTLV-III gp120; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; IC50; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; In Vitro; Individual; Infection; Inhibitory Concentration 50; LAP3; LAV-HTLV-III; LCR1; LESTR; Lead; Legal patent; Libraries; Licensing; Life; Lymphadenopathy-Associated Virus; Lytotoxicity; Mediating; Medication; Membrane Fusion; Membrane Glycoproteins; Methods and Techniques; Methods, Other; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutation Analysis; NNRTI; NPY3R; NPYR; NPYRL; NPYY3R; Names; Nucleosides; Oral; Patents; Pb element; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plasma Membrane; Process; Production; Property; Property, LOINC Axis 2; Protease Antagonists; Protease Inhibitor; Proteinase Inhibitors; Public Health; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Research; Roche brand of pentafuside; Roentgen Rays; Series; Structure; Structure-Activity Relationship; Surface Glycoproteins; T-20; T-20 cpd; T-Lymphotropic Virus Type III Infections, Human; Techniques; Testing; Therapeutic; Transmission; Viral; Virus-HIV; X-Radiation; X-Rays; Xrays; anti-retroviral; antiAIDS agent; antiretroviral; base; chemical structure function; chemotherapy; clinical investigation; conformation; conformational state; cost; cytotoxicity; design; designing; drug candidate; drug resistant; drug/agent; enfuvirtide; env Protein gp120, HIV; generic; gp120; gp120 ENV Glycoprotein; gp120(HIV); heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; improved; indexing; inhibitor; inhibitor/antagonist; member; non-nucleoside RT inhibitors; non-nucleoside reverse transcriptase inhibitors; nonnucleoside reverse transcriptase inhibitors; novel; pentafuside; plasmalemma; public health medicine (field); resistance to Drug; resistant to Drug; small molecule; small molecule libraries; structure function relationship; transmission process",Rational Design of HIV Fusion Inhibitors Targeting gp41,,46221,ADDT,AIDS Discovery and Development of Therapeutics Study Section,,9,366601,
7758322,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI046541-10,,NIAID:320393;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TUCSON,UNITED STATES,BIOCHEMISTRY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"MIESFELD, ROGER L;",1869075;,5R01AI046541,12/01/1999,01/31/2011,"21+ years old; Abnormal Assessment of Metabolism; Adult; Aedes; Aedes (genus); Amino Acids; Ammonia; Blood; Body Tissues; C element; CO2; Carbon; Carbon Dioxide; Carbonic Anhydride; Complex; Culex; Culex (Genus); Culicidae; D-Glucose; Development; Dextrose; Diapause; Digestion; Disease; Disorder; Energy Expenditure; Energy Metabolism; Ensure; Fat Body; Fatty Acids; Female; Future; Generations; Gln; Glucose; Glutamine; Glycogen; Goals; Grant; Hemolymph; Human, Adult; Insecta; Insects; Intermediary Metabolism; Invertebrates, Insects; Investigators; L-Glutamine; L-Proline; Label; Larva; Lipids; METBL; Metabolic; Metabolic Control; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Metabolism, Carbohydrates/Storage/Polysaccharides; Methods; Midgut; Modeling; Mosquito Control; Mosquitoes; Pathway interactions; Peptide Biosynthesis, Ribosomal; Play; Position; Positioning Attribute; Production; Programs (PT); Programs [Publication Type]; Proline; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Synthesis, Ribosomal; Protein Turnover; Proteins; Q. Levoglutamide; Reaction; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Blood; Role; Staging; Time; Tissues; Trehalose; Vitellogenesis; adipogenesis; adult human (21+); alpha-D-Glucopyranoside, alpha-D-glucopyranosyl; aminoacid; base; carbohydrate metabolism; disease/disorder; egg; gene product; lipid biosynthesis; lipogenesis; metabolic abnormality assessment; oxidation; pathway; programs; protein degradation; protein synthesis; social role; sugar",Regulation of Energy Metabolism in Insects,,46541,ZRG1,Special Emphasis Panel,,10,320393,
7758722,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI046564-10,,NIAID:344794;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,PATHOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"BERG, LESLIE J.;",1888163;,5R01AI046564,03/01/2000,01/31/2011,"APC; ATGN; ATP-protein phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Adoptive Transfer; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Antibodies, Blocking; Antigen-Presenting Cells; Antigens; Artifacts; Autoregulation; B blood cells; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Behavior; Binetrakin; Blocking Antibodies; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD132; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Growth in Number; Cell Lineage; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Clinical, Transplantation, Organ; Co-Stimulator; Complement; Complement Proteins; Costimulator; Cytokine Receptors; Cytokine Signal Transduction; Cytokine Signaling; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytotoxic cell; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dendritic Cells; Doctor of Philosophy; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Effector Cell; Egg, Unfertilized; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Thymocyte Activating Factor; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Female, Fluids, Secretions, Ova; Goals; Graft Rejection; Grafting Procedure; HEK3; HP40; High Affinity Interleukin-2 Receptor; Homeostasis; Homolog of Mouse T Cell and Mast Cell Growth Factor 40; Human; Human, General; IL-10; IL-15; IL-2; IL-4; IL-7; IL-9; IL10; IL10A; IL15; IL15 Protein; IL2; IL2 Protein; IL2 Receptors; IL2RG; IL2RG gene; IL4; IL4 Protein; IL7 Protein; IL9 Protein; IMD4; Immune system; Immunobiology; Immunologic Accessory Cells; Immunophysiology; Immunosuppressants; Immunosuppressive Agents; In Vitro; Interleukin 10 Precursor; Interleukin 2; Interleukin 2 Precursor; Interleukin 2 Receptor; Interleukin 7 Precursor; Interleukin 9 Precursor; Interleukin II; Interleukin-10; Interleukin-15; Interleukin-15 Precursor; Interleukin-2; Interleukin-4; Interleukin-4 Precursor; Interleukin-7; Interleukin-9; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Investigators; K lymphocyte; Knock-out; Knockout; Knockout Mice; LCM Viruses; LCMV; Lymphocyte Mitogenic Factor; Lymphocyte Stimulatory Factor 1; Lymphocytic choriomeningitis virus; Lymphopoietin-1; MCGF-2; MGC9721; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow; Mast Cell Growth Factor-2; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitogenic Factor; Molecular Analysis; Monocytes / Macrophages / APC; Morphologic artifacts; Murine; Mus; Mutation; NK Cells; Natural Killer Cells; Normal Cell; Null Mouse; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Ova, Fluids, Secretions; Ovalbumin; Ovum; PTK; Pathway interactions; Peptides; Peripheral; Ph.D.; PhD; Phenotype; Physiological Homeostasis; Play; Population; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Proliferating; Property; Property, LOINC Axis 2; Protein Kinase; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Receptors, Cytokine; Receptors, IL-2; Regulatory T-Lymphocyte; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Risk; Role; Running; SCID; SCIDX; SCIDX1; Severe Combined Immunodeficiency; Severe Combined Immunodeficiency Syndrome; Severe Combined Immunologic Deficiency; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; T cell growth factor; T memory cell; T-Cell Activation; T-Cell Growth Factor; T-Cell Growth Factor 2; T-Cell Growth Factor P40; T-Cell Growth Factor Receptors; T-Cell Stimulating Factor; T-Cell/Mast Cell Growth Factor p40; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TCGF Receptors; Testing; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Transcript Expression Analyses; Transcript Expression Analysis; Transgenic Mice; Transplant Rejection; Transplantation Rejection; Transplantation Surgery; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Veiled Cells; Viral Diseases; Virus; Virus Diseases; Viruses, General; Wild Type Mouse; accessory cell; base; biological signal transduction; body system, allergic/immunologic; clinical data repository; clinical data warehouse; combined T and B cell inborn immunodeficiency; cytokine; data repository; egg/ovum; experiment; experimental research; experimental study; genome mutation; glycogen synthase a kinase; helper T cell; hydroxyalkyl protein kinase; hydroxyaryl protein kinase; immunogen; immunosuppressive; in vivo; inhibitor; inhibitor/antagonist; inhibitory surface receptor; memory T lymphocyte; model organism; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; p40 Cytokine; p40 Protein; pathway; phosphorylase b kinase kinase; programs; reconstitute; reconstitution; relational database; research study; response; social role; thymus derived lymphocyte; tyrosyl protein kinase; viral infection; virus infection",Immunobiology of Jak3 Deficient Mice,,46564,CMIB,Cellular and Molecular Immunology - B Study Section,,10,344794,
7754650,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI046653-10,,NIAID:396424;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IOWA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"HARTY, JOHN T.;",1892883;,5R01AI046653,02/15/2006,01/31/2011,"ATGN; Address; Adjuvant; Agonist; Animal Model; Animal Models and Related Studies; Antigens; Biological Models; Biological Terrorism; Bioterrorism; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Dendritic Cells; Development; Funding; Generations; Goals; Grant; Human; Human, General; INFLM; ITX; Immunity; Immunization; Immunization, Booster; Immunization, Secondary; Immunologic Stimulation; Immunological Stimulation; Immunologically Directed Therapy; Immunostimulation; Immunotherapy; Infection; Infection prevention; Inflammation; Inflammation Mediators; Inflammatory; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; LYT3; Learning; Leishmania; Leishmania (genus); Leishmaniasis; Life; Malaria; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Mice; Model System; Modeling; Models, Biologic; Molecular; Murine; Mus; Paludism; Peptides; Phenotype; Plasmodium Infections; Population; Prevent infection; Regimen; Resolution; Secondary Immunization; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Source; System; System, LOINC Axis 4; T memory cell; T-Cell Development; T-Cell Ontogeny; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T4 Cells; T4 Lymphocytes; Thymus-Dependent Lymphocytes; Time; Vaccination; Vaccine Design; Vaccines; Veiled Cells; biological signal transduction; booster vaccination; cellular targeting; helper T cell; human disease; immune therapy; immunogen; improved; in vivo; memory CD4 T cell; memory CD4 T lymphocyte; memory T lymphocyte; model organism; pathogen; response; thymus derived lymphocyte; tumor; vaccine efficacy",Accelerated CD8 T cell memory after DC vaccination,,46653,ZRG1,Special Emphasis Panel,,10,396424,
7760591,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI046657-10,,NIAID:364245;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"PEREIRA, LENORE PALMA;",1863414;,5R01AI046657,02/01/2000,01/31/2011,"92-kDa Gelatinase; 92-kDa Type IV Collagenase; Affect; Binding; Binding (Molecular Function); Biopsy Sample; Biopsy Specimen; Blood; Blood flow; Body Tissues; CAV1; CMV; Caveolae; Caveolae Protein, 22kD; Caveolas; Caveolin 1, Caveolae Protein, 22kD; Cell Adhesion; Cell Differentiation; Cell Differentiation process; Cells; Cellular Adhesion; Chorionic villi; Clinical; Complex; Conceptus; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; Cytotrophoblast; DNA, Viral; Development; Disease; Disorder; Drug Design; Embryonic Tissue, Placenta; Endocytosis; Endothelial Cells; Endothelium; Environment; Extracellular Matrix, Integrins; Fc receptor, neonatal; FcRn; FcRn neonatal transfer protein; FcRn protein, human; Fetus; Gamma Globulin, 7S; Gelatinase B; Genital System, Female, Uterus; Gestation; Grant; HCMV; HCMV receptor; HLA G antigen; HLA-G; Human; Human, General; IgG; Immune; Immunoglobulin G; In Vitro; Inclusion Disease; Infection; Integrins; Invaded; Investigators; Knowledge; Laboratories; Link; Lipid Rafts, Cell Membrane; MMP-9; MMP-9 Protein; MMP9; Macrophage Gelatinase; Man (Taxonomy); Man, Modern; Maternal-Fetal Exchange; Matrix Metalloproteinase-9; Mediating; Membrane; Membrane Microdomains; Modeling; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Mothers; Nutrient; O element; O2 element; Oxygen; Pathway interactions; Pattern; Placenta; Placenta-Tissue, Cells; Placental Villi; Placentoma, Normal; Placentome; Pregnancy; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Proteins; Receptor Protein; Research Personnel; Researchers; Reticuloendothelial System, Blood; Role; Route; Salivary Gland Virus Disease; Salivary Gland Viruses; Site; Specialized Epithelial Cell; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stem cells; Structure of cytotrophoblast; Surface; Syncytiotrophoblast; Testing; Tissues; Transmission; Transplacental Exposure; Type V Collagenase; United States; Uterus; VESCL; VIP21; VIP21 protein; Vesicle; Villus; Viral; Viral Diseases; Virion; Virus; Virus Diseases; Virus Particle; Viruses, General; base; caveolin; caveolin 1; congenital cytomegalovirus; congenital cytomegalovirus infection; cytomegalovirus group; cytomegalovirus receptor; cytotrophoblast; design; designing; disability; disease/disorder; experiment; experimental research; experimental study; fetal; gene product; human cytomegalovirus; in utero; in vivo; insight; lipid raft; maternal-fetal interface; membrane structure; migration; neonatal Fc receptor; new approaches; novel; novel approaches; novel strategies; novel strategy; pathogen; pathway; polarized cell; prenatal; prevent; preventing; progenitor; programs; receptor; receptor expression; research study; social role; transcytosis; transmission process; unborn; uptake; vesicular integral membrane protein 21 kDa; viral DNA; viral infection; virus DNA; virus infection; womb",Fetal CMV Infection: Role of the Human Placenta,,46657,VIRB,Virology - B Study Section,,10,364245,
7758219,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI046706-10,,NIAID:465189;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"PIER, GERALD B;",1868214;,5R01AI046706,02/01/2001,01/31/2011,"2-Amino-2-Deoxyglucose; ATGN; Acetylation; Actinobacillus; Affinity; Animal Diseases; Animals; Anti-Bacterial Agents; Antibacterial Agents; Antibodies; Antigen Targeting; Antigenic Determinants; Antigens; Assay; Bacteria; Bacterial Infections; Bacterial Vaccines; Bacterin; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Bordetella; Cell surface; Chemical Structure; Clinical; Clinical Evaluation; Clinical Testing; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communicable Diseases; Communities; Complement; Complement Proteins; Conjugate Vaccines; D-Glucose, 2-amino-2-deoxy-; Deposit; Deposition; Disease; Disorder; E coli; Editorial Comment; Editorial Comment (PT); Epitopes; Escherichia coli; Fixation; Funding; GeneHomolog; Genus staphylococcus; Glucosamine; Glycans; Goals; Grant; Homolog; Homologous Gene; Homologue; Hu-mABs; Human; Human, General; Immunity; In Vitro; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Killings; Lead; Link; Man (Taxonomy); Man, Modern; Membrane Proteins; Membrane-Associated Proteins; Mole the mammal; Molecular Interaction; Moles; Monosaccharides; Oligosaccharides; Organism; P. pseudotuberculosis; Pasteurella pestis; Pasteurella pseudotuberculosis; Pb element; Phage Display; Plague; Polysaccharides; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Public Health; Published Comment; Research; Research Personnel; Researchers; Ribosomes; S. aureus; S.aureus; Staphylococcus; Staphylococcus aureus; Surface; Surface Proteins; Technology; Vaccination; Vaccines; Vaccines, Conjugate; Viewpoint; Viewpoint (PT); Virulence; Y. enterocolitica; Y. pestis; Y. pseudotuberculosis; Y.enterocolitica; Y.pestis; Yersinia; Yersinia enterocolitica; Yersinia pestis; Yersinia pestis disease; Yersinia pseudotuberculosis; amino group; anti-bacterial; antibacterial; bacterial disease; base; clinical test; disease/disorder; gene product; heavy metal Pb; heavy metal lead; human monoclonal antibodies; immunogen; improved; in vivo; living system; p-GlcNac; pathogen; pathogenic E. coli; pathogenic Escherichia coli; poly-N-acetyl glucosamine; polyclonal antibody; pre-clinical; preclinical; programs; prophylactic; protective efficacy; public health medicine (field); research clinical testing; sample fixation",Poly-N-acetyl glucosamine as a vaccine for bacterial pathogens,,46706,VMD,Vaccines Against Microbial Diseases Study Section,,10,465189,
7761756,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI046954-10,,NIAID:319685;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"GARCIA-SASTRE, ADOLFO ;",2108543;,5R01AI046954,12/01/1999,01/31/2011,"Affect; Amino Acids; Anti-Viral Response; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Area; Attenuated; Attenuated Vaccines; B Virus; Binding; Binding (Molecular Function); C-terminal; Cell Communication and Signaling; Cell Signaling; Cells; Cercopithecid herpesvirus 1; Cercopithecine Herpesvirus 1; DNA Helicases; DNA Unwinding Proteins; DNA unwinding enzyme; Data; Deletion Mutation; Double-Stranded RNA; EC 2.7; Endogenous Interferon Beta; Genes; Genetic Alteration; Genetic Change; Genetic defect; Grippe; Herpes Virus B; Herpes simiae; Herpesvirus 1 (alpha), Cercopithecine; Herpesvirus 1, Cercopithecine; Herpesvirus B; Herpesvirus simiae; Human Virus; IFN; IFN-Beta; IFNb; Immune response; Influenza; Influenza A virus; Influenza B virus; Influenza Virus; Influenza Viruses Type A; Influenza Viruses Type B; Interferon Activation; Interferon Beta, Natural; Interferon Type I; Interferon, Fibroblast; Interferon-beta; Interferons; Intracellular Communication and Signaling; Investigators; Kinases; Knockout Mice; Knowledge; Light; Mediating; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Interaction; Molecular Mechanisms of Action; Monkey B Virus; Mutation; N-terminal; NDV; NH2-terminal; NIAID; National Institute of Allergy and Infectious Disease; Natural human interferon beta; Newcastle disease virus; Nonstructural Protein; Nuclear RNA; Null Mouse; Orthomyxovirus Type A; Orthomyxoviruses Type B; Paramyxovirus; Paramyxovirus 1, Avian; Pathogenicity; Pathogenicity Factors; Phosphorylation; Phosphotransferases; Photoradiation; Play; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Inhibition; Protein Phosphorylation; Protein, Nonstructural; Proteins; RNA Helicase; RNA, Double-Stranded; RNA, Nuclear; Recombinants; Research; Research Design; Research Personnel; Researchers; Role; Signal Transduction; Signal Transduction Systems; Signaling; Simian Herpesvirus; Structural Protein; Study Type; System; System, LOINC Axis 4; Transphosphorylases; Vaccines, Attenuated; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virulence; Virulence Factors; Virulent; Virus Diseases; Work; aminoacid; attenuation; base; biodefense; biological signal transduction; cellular targeting; design; designing; dsRNA; experiment; experimental research; experimental study; falls; flu infection; gene product; genome mutation; helicase; host response; immunogenic; immunoresponse; influenza infection; influenzavirus; influenzavirus (unspecified); live vaccine; mutant; novel; prevent; preventing; programs; research study; response; social role; study design; transcription factor; vaccine candidate; viral infection; virus infection; virus protein",Virulence factors of influenza virus: The NS1 protein,,46954,VIRB,Virology - B Study Section,,10,319685,
7761782,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI047141-10,,NIAID:329745;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RICHMOND,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"CORNELISSEN, CYNTHIA NAU;",1888143;,5R01AI047141,04/01/2000,02/28/2011,"ATGN; Abscission; Address; Adjuvant; Animals, Laboratory; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Antigens; Aquadiol; Assay; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Cell Culture System; Cell surface; Cholera Toxin B Subunit; Cholera Toxin Protomer B; Choleragenoid; Codon, Initiation; Codon, Initiator; Codon, Start; Complex; Cooperative Behavior; Diagnostic Findings; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Epithelial Cells; Epitopes; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Excision; Extirpation; Fe element; Genetic; Genetics-Mutagenesis; Goals; Gonococcal Infection; Gonococcal Transferrin Receptor; Gonococcus; Gonorrhea; Granulocyte/Pollen-Binding Protein; Human; Human, General; ITX; Immune response; Immunofluorescence Microscopy; Immunologically Directed Therapy; Immunotherapy; Individual; Initiator Codon; Integral Membrane Protein; Intercistronic Region; Intervention; Intervention Strategies; Intrinsic Membrane Protein; Iron; Laboratory Animals; Lead; Lipoprotein (a); Lipoprotein Lp(a); Lipoproteins; Lp(a); Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane; Membrane Proteins; Membrane-Associated Proteins; Messenger RNA; Mice; Microscopy, Immunofluorescence; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Transport; Murine; Mus; Mutagenesis; N. gonorrhoeae; N.gonorrhoeae; Neisseria gonorrhoeae; Nucleic Acid Regulatory Sequences; Organism; Ovocyclin; Ovocylin; Paladin Brand of Levonorgestrel; Pathway interactions; Pb element; Phase; Plan B; Play; Process; Progynon; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA, Messenger; Receptor Protein; Regions, Intergenic; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Relative; Relative (related person); Removal; Siderophilin; Signs and Symptoms; Source; Stimulus; Structure; Structure-Activity Relationship; Surface; Surface Proteins; Surgical Removal; Tbp1 Transferrin-Binding Protein; TbpA Transferrin-Binding Protein; Therapeutic Estradiol; Transferrin; Transferrin Receptor; Transferrin-Binding Protein A; Transmembrane Protein; Transport Process; Urethritis; Vaccinated; Vaccination; Vaccines; Women's Capital Brand of Levonorgestrel; antibody biosynthesis; bactericidal; bactericide; chemical structure function; defined contribution; design; designing; disease/disorder; gene product; genetic regulatory element; heavy metal Pb; heavy metal lead; host response; human male; immune therapy; immunogen; immunogenicity; immunoglobulin biosynthesis; immunoprophylaxis; immunoresponse; in vivo; interventional strategy; living system; mRNA; membrane structure; mouse model; novel; pathogen; pathway; prevent; preventing; protein expression; receptor; receptor binding; receptor function; resection; structure function relationship; uptake",A Molecular Study of the Gonococcal Transferrin Receptor,,47141,ZRG1,Special Emphasis Panel,,10,329745,
7754887,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI047153-10,,NIAID:265321;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,EAST LANSING,UNITED STATES,CHEMISTRY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"WELIKY, DAVID PAUL;",2103418;,5R01AI047153,02/01/2001,01/31/2011,"AIDS; AIDS Virus; Abbreviations; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affinity; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Blood erythrocyte; Blood normocyte; C-terminal; Catalysis; Cell Nucleus; Cell fusion; Cell membrane; Cells; Chemicals; Chimera Protein; Chimeric Proteins; Cholest-5-en-3-ol (3beta)-; Cholesterol; Circular Dichroism; Coupled; Coupling; Cytoplasmic Membrane; Data; Dependence; Detergents; Development; Disease; Disorder; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Environment; Erythrocytes; Erythrocytic; Ethers; Fusion Protein; Genetic Alteration; Genetic Change; Genetic defect; Glass; Glossary; Goals; Grippe; HIV; HTLV-III; Hemagglutinin; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Infection; Influenza; Influenza Virus; LAV-HTLV-III; Label; Link; Lipids; Liquid substance; Lymphadenopathy-Associated Virus; Marrow erythrocyte; Measurement; Membrane; Membrane Fusion; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Micelles; Model System; Models, Biologic; Models, Structural; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Mutation; NMR Spectroscopy; Nucleus; Paramagnetic Resonance; Peptide Domain; Peptides; Plasma Membrane; Play; Point Mutation; Protein Domains; Proteins; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Resolution; Reticuloendothelial System, Erythrocytes; Role; Sampling; Spectroscopy, ESR; Spectroscopy, NMR; Structural Models; Structure; Surface Proteins; Techniques; Tertiary Protein Structure; Testing; Therapeutic; Time; Torsion; Torsion (malposition); VESCL; Vesicle; Viral; Viral Fusion Proteins; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus-HIV; Viruses, General; aminoacid sequence of peptide; aminoacid sequence of protein; analog; analytical ultracentrifugation; base; blood corpuscles; conformation; conformational state; cross-link; crosslink; dimer; disease/disorder; electron paramagnetic resonance spectroscopy; experiment; experimental research; experimental study; flu infection; fluid; fusion protein (viral coat); gene product; genome mutation; influenza infection; influenzavirus; influenzavirus (unspecified); liquid; magnetic field; membrane structure; monomer; novel; nuclear magnetic resonance spectroscopy; peptide sequence; plasmalemma; protein aminoacid sequence; prototype; research study; social role; solid state nuclear magnetic resonance; virus protein",Solid-State NMR of Viral Fusion Peptides and Proteins,,47153,ZRG1,Special Emphasis Panel,,10,265321,
7763906,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI047723-08,,NIAID:447567;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TAMPA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,09,069687242,US,FL,33612,UNIVERSITY OF SOUTH FLORIDA,"SLEASMAN, JOHN W;",2505327;,5R01AI047723,04/15/2001,01/31/2011,"0-11 years old; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adolescent; Adolescent Youth; Amino Acid Sequence; Amino Acid Substitution; Anti-Retroviral Agents; Antiproteases; Antiretroviral Agents; Archives; Blood Plasma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells, CD4; Child; Child Youth; Children (0-21); Development; Disease Progression; Drug resistant viral; Endopeptidase Inhibitors; Esteroproteases; Evolution; FLR; Failure (biologic function); Gagging; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic Markers; Genetic defect; Genome; Genotype; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Host Factor; Host Factor Protein; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, Child; Immune; Immune Function, Cellular; Immune response; Immunity; Immunodeficiency Virus Type 1, Human; Individual; Integration Host Factors; Investigation; LAV-HTLV-III; Lead; Lymphadenopathy-Associated Virus; Maps; Mutation; Outcome; Output; PBMC; Patients; Pb element; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Peripheral Blood Mononuclear Cell; Phase; Plasma; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Protease Antagonists; Protease Inhibitor; Proteases; Protein Structure, Primary; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; Reflex, Pharyngeal; Regimen; Research; Reticuloendothelial System, Serum, Plasma; Reticuloendothelial System, Thymus; Serum, Plasma; T-Cell Activation; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Variant; Variation; Viral; Viral Burden; Viral Load; Viral Load result; Virus; Virus-HIV; Viruses, General; anti-retroviral; antiretroviral; antiretroviral therapy; children; cohort; drug resistant virus; failure; genetic determinant; genome mutation; heavy metal Pb; heavy metal lead; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; immune function; immunoresponse; juvenile; juvenile human; new therapeutics; next generation therapeutics; novel; novel therapeutics; peripheral blood; pressure; protein sequence; recombinant virus; reconstitute; reconstitution; response; success; thymocyte; thymus derived lymphocyte; youngster",Impact of HIV-1 Genotype on Therapy Response in Children,,47723,ZRG1,Special Emphasis Panel,,8,447567,
7754875,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI047833-10,,NIAID:371317;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"PEAR, WARREN S;",2110059;,5R01AI047833,08/01/2000,01/31/2011,"21+ years old; Adult; Antimorphic mutation; Assay; Autoregulation; B-Cell Development; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood (Leukemia); Blood Precursor Cell; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell membrane; CellLine; Cells; Cellular Expansion; Cellular Growth; Commit; Crossmatching, Tissue; Cytoplasmic Membrane; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drosophila; Drosophila genus; Enhancers; Event; Family; Fruit Fly, Drosophila; Funding; Gene Expression; Gene Transcription; GeneHomolog; Genetic Transcription; Goals; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Histocompatibility Testing; Homeostasis; Homolog; Homologous Gene; Homologue; Human, Adult; Immune system; Intracellular Communication and Signaling; Investigators; Lead; Leukemias, General; Ligands; Lymphocyte; Lymphocytic; Mammals, Mice; Mice; Modeling; Mother Cells; Multipotent Stem Cells; Murine; Mus; Nucleus; Organ; Pb element; Pear; Peripheral; Physiological Homeostasis; Plasma Membrane; Play; Population; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; RNA Expression; Receptor Protein; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stem cells; Stromal Cells; T-Cell Development; T-Cell Ontogeny; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocyte Subsets; Therapeutic; Thymocyte Development; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissue Crossmatchings; Tissue Typing; To specify; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Work; adult human (21+); base; biological signal transduction; body system, allergic/immunologic; bone; cell growth; cultured cell line; family influence; fruit fly; heavy metal Pb; heavy metal lead; histocompatibility typing; improved; in vivo; insight; leukemia; lymph cell; multipotent progenitor; new therapeutics; next generation therapeutics; notch; notch protein; notch receptors; novel; novel therapeutics; organ system, allergic/immunologic; plasmalemma; progenitor; programs; receptor; self-renewal; social role; thymocyte; thymus derived lymphocyte; transcription factor; tumor",Notch regulation of hematopoetic cell fates,,47833,CMI,Cellular and Molecular Immunology - A,,10,371317,
7762236,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI048071-10,,NIAID:456570;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN ANTONIO,UNITED STATES,,20,007936834,US,TX,782450549,SOUTHWEST FOUNDATION FOR BIOMEDICAL RES,"ANDERSON, TIM J;",6412770;,5R01AI048071,09/01/2000,01/31/2011,"Active Follow-up; After Care; After-Treatment; Aftercare; Alleles; Allelomorphs; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Artemisinins; Burma; Candidate Disease Gene; Candidate Gene; Chromosome 5; Chromosomes, Human, Pair 5; Clinic; Clinical; Collaborations; DNA Alteration; DNA mutation; Drug resistance; Drugs; Effectiveness; Evolution; Funding; Gene Alteration; Gene Mutation; Genes; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetic mutation; Genome; Genotype; Killings; Laboratories; Location; Malaria; Maps; Measures; Medication; Medicine; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Monitor; Mortality; Mortality Vital Statistics; Mutation; Myanmar; Nucleotides; Paludism; Parasites; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plasmodium Infections; Plasmodium falciparum; Point Mutation; Polymorphism (Genetics); Polymorphism, Genetic; Public Health; QTL; Quantitative Trait Loci; Recrudescences; Research; Resistance; Running; Sampling; Science of Medicine; Screening Result; Sequence Alteration; Series; Thailand; Transfection; Treatment Efficacy; Treatment Failure; Work; arteannuin; artemisinin; artemisinine; clinical relevance; clinically relevant; college; comparative; drug resistant; drug/agent; efficacy trial; experiment; experimental research; experimental study; follow-up; genome mutation; improved; in vivo; polymorphism; public health medicine (field); qinghaosu; quing hau sau; quinghaosu; research study; resistance to Drug; resistant; resistant to Drug; response; therapeutic efficacy; therapeutically effective; tool",Mapping Drug Resistance Genes in Plasmodium Falciparum,,48071,ZRG1,Special Emphasis Panel,,10,456570,
7758331,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI048073-10,,NIAID:435639;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,603880287,US,CA,92037,LA JOLLA INST FOR ALLERGY & IMMUNOLGY,"WARE, CARL F;",1898316;,5R01AI048073,07/01/2000,01/31/2011,"APO2L; Address; Agonist; Antigen Receptors; Antigenic Determinants; Apo-2L; Architecture; Attenuated; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Binding Determinants; Biological; Blood Vessels; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CMV; Cell Communication; Cell Communication and Signaling; Cell Culture Techniques; Cell Interaction; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-to-Cell Interaction; Cells; Cervical; Communication; Critical Paths; Critical Pathways; Cytomegalovirus; DIF; Defense Mechanisms; Dendritic Cells; Endothelial Cells; Engineering / Architecture; Epithelial Cells; Epitopes; Family member; Fibroblasts; Genetic; Genetics-Mutagenesis; HCMV; HVEM protein; Herpesviridae; Herpesviruses; Host Defense; Host resistance; Human; Human, General; HveA protein; IFN; ITIM; Immune; Immune response; Immune system; Immunoreceptor Tyrosine-Based Inhibitory Motif; Infection; Interferons; Intracellular Communication and Signaling; Investigation; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knockout Mice; LTA; Lymphocyte; Lymphocytic; Lymphoid Cell; Lymphotoxin; Lymphotoxin A; Lymphotoxin-alpha; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Molecular Interaction; Murine; Mus; Mutagenesis; Mutagenesis, Site-Directed; Null Mouse; Ortholog; Orthologous Gene; Pathogenesis; Pathway interactions; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiological; Principal Investigator; Production; Receptor Protein; Receptor Signaling; Receptors, Antigen; Recruitment Activity; Regulation; Reporter; Resistance; Role; Salivary Gland Viruses; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Stromal Cells; System; System, LOINC Axis 4; T-Cell Activation; T-Cell Proliferation; T-Cells; T-Lymphocyte; TL2; TNF; TNF A; TNF Superfamily, Member 1; TNF gene; TNF-b; TNF-beta; TNFRSF14; TNFSF1; TNFSF10; TNFSF10 gene; TNFSF2; TR2 protein; TRAIL; Targeted DNA Modification; Targeted Modification; Testing; Thymus-Dependent Lymphocytes; Tissues; Translating; Translatings; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-Beta; Veiled Cells; Viral; Virus; Viruses, General; base; biological signal transduction; body system, allergic/immunologic; cell type; cytokine; cytomegalovirus group; design; designing; experiment; experimental research; experimental study; herpes virus; herpesvirus entry mediator; host response; human cytomegalovirus; immunoresponse; in vivo; intercellular communication; language translation; lymph cell; macrophage; mouse model; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathogen; pathway; prevent; preventing; psychological defense mechanism; receptor; recruit; research study; resistant; response; social role; thymus derived lymphocyte; tumor necrosis factor receptor subfamily, member 14; vascular",Anti-herpesvirus Signaling by LTalphabeta/LIGHT Cytokines,,48073,ZRG1,Special Emphasis Panel,,10,435639,
7768461,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI048125-07,,NIAID:361282;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"CANTOR, HARVEY ;",1868241;,5R01AI048125,04/01/2000,01/31/2013,"2ar peptide; ATGN; Accounting; Alferon; Alpha-Beta-Omega Interferon Receptor-2; Antigen Presentation; Antigens; Autoantigens; Autoimmune Responses; Autoimmune Status; Autoimmunity; Autologous Antigens; Binding; Binding (Molecular Function); Biological Function; Biological Process; Bone Formation; Cell Communication and Signaling; Cell Signaling; Cells; Cold-Insoluble Globulins; Complex; Cross Presentation; Dendritic Cells; Development; Disease; Disorder; EAE; Encephalomyelitis, Allergic; Endosomes; Eta-1 protein; Eta-1-Op protein; Exons; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; FN1; FNZ; Fibronectin 1; Fibronectins; Funding; G-interferon; Gene Expression; Gene Products, RNA; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Ginterferon; Grant; H-2Q1; Hortega cell; IFN Alpha; IFN-Alpha-REC; IFN-R; IFN-alphaR; IFN-alphabetaR; IFNABR; IFNa; IRAK; IRAK1; IRAK1 gene; Immune response; In Vitro; Infection; Interferon Alfa-n3; Interferon Alpha Receptor Complex; Interferon Alpha-Beta Receptor Beta Chain; Interferon Alpha-Beta Receptor-2; Interferon Beta Receptor; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-Alpha-Beta Receptor; Interferon-alpha; Intracellular Communication and Signaling; Investigation; Isoforms; Knock-in; Knock-in Mouse; LETS Proteins; Large External Transformation-Sensitive Protein; Lead; MS (Multiple Sclerosis); Mammals, Mice; Mediating; Mice; Mice, Mutant Strains; Microglia; Modeling; Molecular; Molecular Interaction; Multiple Sclerosis; Murine; Mus; Mutant Strains Mice; Mutation; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Osteogenesis; Pathway interactions; Pb element; Peptides; Phosphorylation; Physiologic; Physiological; Population; Production; Protein Isoforms; Protein Phosphorylation; Proteins; Qa-1; Qa-1 Antigen; Qa1; Qed-1; RNA; RNA, Non-Polyadenylated; Receptor Protein; Receptosomes; Research; Ribonucleic Acid; Role; Sclerosis, Disseminated; Self-Antigens; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specific qualifier value; Specified; T-Cells; T-Lymphocyte; Testing; Therapeutic Effect; Thymus-Dependent Lymphocytes; Translations; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascularization; Veiled Cells; alpha 2-Surface Binding Glycoprotein; autoimmune encephalomyelitis; base; biological signal transduction; bone sialoprotein 1; bone sialoprotein I; cell type; cytokine; disease/disorder; early T-lympocyte activation-1 protein; experiment; experimental research; experimental study; gene product; genome mutation; gitter cell; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; insight; insular sclerosis; interferon alpha receptor; interferon alpha-beta receptor; interferon alphabeta receptors; mannose receptor; mesoglia; microglial cell; microgliocyte; mouse mutant; mutant; novel therapeutic intervention; osteopontin; pathway; pelle; perivascular glial cell; phosphoprotein I, 2aR; prevent; preventing; public health relevance; receptor; research study; response; secreted phosphoprotein 1; selective expression; selectively expressed; self recognition (immune); sialoprotein 1; social role; thymus derived lymphocyte; uptake",Innate cytokine responses that regulate autoimmunity," Project narrative: The Osteopontin (Opn) gene is important in diverse biological processes, including immune responses, vascularization and bone formation, through its interaction with different cell types. Our recent discovery of the contribution of distinct secreted and intracellular isoforms of Opn to the generation of Th17 and Th1 subsets fills an important gap in understanding the genesis of these subsets in normal and autoimmune responses. We will generate mutant mice that express the intracellular or secreted Opn isoform for analysis of the contribution of each to protection again infection and in a murine model of Multiple Sclerosis.",48125,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,7,361282,
7771682,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI048371-09,,NIAID:318742;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"HIOE, CATARINA E;",1874551;,5R01AI048371,10/01/2000,02/28/2011,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigen Presentation; Antigen Presentation Pathway; Antigen Processing and Presentation; Antigen Targeting; Antigen Variation; Antigenic Determinants; Antigenic Variability; Antigenic Variation; Antigens; Attention; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Binding Sites; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CTL; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; Cell-Mediated Lympholytic Cells; CellLine; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Class II Antigens; Class II Major Histocompatibility Antigens; Clinical; Clinical Trials; Clinical Trials, Unspecified; Combining Site; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Development; Effector Cell; Envelope Glycoprotein gp120, HIV; Epitopes; FLR; Failure (biologic function); Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Genetic Alteration; Genetic Change; Genetic defect; Glycans; Glycoproteins; Goals; HIV; HIV Envelope Protein gp120; HIV Infections; HIV vaccine; HIV-1; HIV-I; HIV/AIDS Vaccines; HIV1; HTLV-III; HTLV-III Infections; HTLV-III gp120; HTLV-III-LAV Infections; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Histocompatibility Antigens Class II; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; I-A Antigen; Ia Antigens; Ia-Like Antigens; Immune Response Antigens; Immune response; Immune system; Immune-Response-Associated Antigens; Immunodeficiency Virus Type 1, Human; In Vitro; Inducer Cells; Infection; LAV-HTLV-III; LYT3; Lead; Ligand Binding Protein; Link; Lymphadenopathy-Associated Virus; MHC Class II; MHC Class II Genes; MHC Class II Molecule; MHC Class II Protein; MHC class II antigen; Maintenance; Maintenances; Major Histocompatibility Complex Class II; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Memory; Metabolic Glycosylation; Mice; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Murine; Mus; Mutate; Mutation; N-Glycosylation Site; Patients; Pb element; Plasmids; Point Mutation; Polysaccharides; Position; Positioning Attribute; Process; Production; Proliferating; Property; Property, LOINC Axis 2; Proteins; Proteolytic Clipping; Proteolytic Processing; Reactive Site; Recombinants; Reporting; Site; Subcellular Process; System; System, LOINC Axis 4; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Vaccine Design; Vaccines; Viral; Virus; Virus-HIV; Viruses, General; Work; antibody biosynthesis; base; body system, allergic/immunologic; clinical investigation; coat (enveloped virus); cultured cell line; design; designing; env Protein gp120, HIV; failure; fighting; gene product; genome mutation; glycosylation; gp120; gp120 ENV Glycoprotein; gp120(HIV); gp160; heavy metal Pb; heavy metal lead; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunogen; immunogenic; immunoglobulin biosynthesis; immunoresponse; in vivo; membrane structure; mutant; neutralizing antibody; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pandemic; pandemic disease; peripheral blood; prevent; preventing; response; thymus derived lymphocyte; tool; vaccine development; virus envelope",HIV Vaccines that Elicit Immune Responses to Virus Env,,48371,AIP,AIDS Immunology and Pathogenesis Study Section,,9,318742,
7760852,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI048689-10,,NIAID:358351;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"HULTGREN, SCOTT J;",1903078;,5R01AI048689,02/01/2001,01/31/2011,"Adhesins, Bacterial; Adhesions; Adhesives; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acids; Amyloid; Amyloid Proteins; Amyloid Substance; Amyloid fibers; Amyloidosis; Antibiotic Resistance; Architecture; Assay; Atomic Force Microscope; Atomic Force Microscopy; Bacteria; Bacterial Adhesins; Bacterial Infections; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biochemistry; Biogenesis; Biologic Assays; Biological Assay; Biological Models; Bladder; Body Tissues; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell surface; CellLine; Cells; Chaperone; Characteristics; Chemistry, Biological; Combining Site; Communicable Diseases; Communities; Complex; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cysteine; Cystitis; DNA Molecular Biology; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deposit; Deposition; Disease; Disorder; Distal; Electron Microscopy; Engineering / Architecture; Environment; Epithelium; Escherichia; Event; Fiber; Fimbriae Proteins; Force Microscopy; Gene Expression; GeneHomolog; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gram-Negative Bacteria; Grant; Growth; HSP; Half-Cystine; Heat Stress; Heat Stress Disorders; Heat Stress Syndromes; Heat shock proteins; Homolog; Homologous Gene; Homologue; Host Defense; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Immune Globulins; Immunoelectron Microscopy; Immunoglobulins; Immunoglobulins / Antibodies; In Vitro; Individual; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intracellular Communication and Signaling; L-Cysteine; Lead; Length; Lewy Body Parkinson Disease; Location; Logic; Man (Taxonomy); Man, Modern; Mediating; Medicine; Membrane; Methods and Techniques; Methods, Other; Microbial Biofilms; Microscopy; Microscopy, Atomic Force; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Model System; Modeling; Models, Biologic; Molecular; Molecular Biology; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Genetic; Molecular Genetics; Molecular Interaction; Molecular Stereochemistry; Mutation; N-terminal; NH2-terminal; Operon; Organism; Origin of Life; Outcome; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Pb element; Peptides; Periplasmic Proteins; Periplasmic Space; Pili Structural Proteins; Pilin; Pilum; Play; Precipitation; Prevention; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Proline-Rich Domain; Proline-Rich Region; Property; Property, LOINC Axis 2; Proteins; Reaction; Reactive Site; Reagent; Receptor Protein; Regulation; Reporter; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Role; Scanning Force Microscopy; Science of Medicine; Series; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Specificity; Stress Proteins; Structural Protein; Structure; Surface; Symptoms; System; System, LOINC Axis 4; Techniques; Testing; Tissue Growth; Tissues; Tripcellim; Tropism; Trypsin; UPEC; UTI; Urinary System, Bladder; Urinary System, Urine; Urinary tract; Urinary tract infection; Urinary tract infectious disease; Urine; Uropathogenic E coli; Uropathogenic E. coli; Uropathogenic E.coli; Uropathogenic Escherichia coli; Virulence; Virulent; Work; X Ray Crystallographies; X-Ray Crystallography; adhesin; aminoacid; amyloid assembly; amyloid disease; amyloid formation; antibiotic resistant; bacterial disease; base; biofilm; biological signal transduction; clinical data repository; clinical data warehouse; combat; conformation; conformational state; cultured cell line; data repository; dementia of the Alzheimer type; disease/disorder; extracellular; fimbriae; flexibility; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; in vitro Model; in vivo; infectious organism; insight; interdisciplinary approach; interest; living system; macromolecular assembly; membrane structure; molecular dynamics; monomer; mouse model; mutant; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; pathogen; pathogenic bacteria; pathway; periplasm; periplasmic; pilus; prevent; preventing; primary degenerative dementia; programs; protein folding; protein protein interaction; prototype; receptor; receptor binding; relational database; rod cell; senile dementia of the Alzheimer type; social role; treatment strategy; urinary bladder; wound",Pathogenic Fiber Formation in Bacteria: Structural Basis,,48689,BACP,Bacterial Pathogenesis Study Section,,10,358351,
7755826,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI048770-10,,NIAID:385463;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"ROY, CRAIG R.;",1903571;,5R01AI048770,01/01/2001,01/31/2011,"ATGN; Address; Animal Model; Animal Models and Related Studies; Antigen Presentation; Antigen Processing; Antigen Processings; Antigens; Assay; Bioassay; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Signaling; Cells; Cytosol; Defect; Dendritic Cells; Detection; Endoplasmic Reticulum; Epithelial Cells; Ergastoplasm; Eukaryote; Eukaryotic Cell; Event; External Domain; Extracellular Domain; Family member; Generalized Growth; Genes, Class I; Genes, MHC Class I; Goals; Growth; Host Defense; Immune; Immune response; Immune system; Immunity; Infection; Intracellular Communication and Signaling; Invaded; Legionella; Legionella pneumophila; Life Style; Lifestyle; Link; Lymphocyte; Lymphocytic; Lysosomes; MHC Class I; MHC Class I Genes; Mediating; Mice, Mutant Strains; Microbe; Mutant Strains Mice; Organelles; Pathway interactions; Pattern recognition receptor; Phagocytes; Phagocytic Cell; Play; Production; Protein Family; Proteins; Receptor Protein; Recruitment Activity; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Surface; T-Cells; T-Lymphocyte; TLR protein; Thymus-Dependent Lymphocytes; Tissue Growth; Toll-like receptors; VESCL; Vacuole; Veiled Cells; Vesicle; amebocyte; anti-microbial; antigen processing; antimicrobial; biological signal transduction; body system, allergic/immunologic; cytokine; eukaryotida; gene product; host response; immunogen; immunoresponse; in vivo; interest; lymph cell; macrophage; microbial; microbial antigen; microorganism antigen; model organism; mouse mutant; mutant; ontogeny; organ system, allergic/immunologic; pathogen; pathway; receptor; recruit; respiratory; response; social role; thymus derived lymphocyte; trafficking; uptake",EVASION OF ANTIGEN PRESENTATION BY VACUOLAR PATHOGENS,,48770,ZRG1,Special Emphasis Panel,,10,385463,
7759584,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI048785-08,,NIAID:413355;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,PATHOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SURESH, MARULASIDDAPPA ;",6520818;,5R01AI048785,03/01/2002,01/31/2013,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Animal Welfare; Antigens; Arenavirus; Bibliography; Burkitt Herpesvirus; Burkitt Lymphoma Virus; CD8; CD8B; CD8B1; CD8B1 gene; CDK Inhibitor Protein; CDKI Protein; CMV; Cell Cycle; Cell Cycle Arrest; Cell Differentiation; Cell Differentiation process; Cell Division Cycle; Cells; Complication; Country; Cues; Cyclin Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor; Cytomegalovirus; Development; E-B Virus; EB virus; EBV; Ecological impact; Effector Cell; Environment; Environmental Impact; Epstein Barr Virus; Epstein-Barr Virus; Equipment; Ethics Committees, Research; Evaluation; Gene Expression Profile; Gene Targeting; Genes; Genetic; HCMV; HHV-4; HIV; HTLV-III; Hepatitis B; Hepatitis B Infection; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Human Herpesvirus 4; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IACUC; IRBs; Immunity; Impact, Environmental; Infectious Mononucleosis Virus; Institutional Animal Care and Use Committee; Institutional Review Boards; International; LAV-HTLV-III; LCM Viruses; LCMV; LYT3; Lymphadenopathy-Associated Virus; Lymphocytic choriomeningitis virus; Mammals, Mice; Memory; Mice; Murine; Mus; Pathway interactions; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proliferating; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Role; Salivary Gland Viruses; Shapes; T memory cell; T-Cells; T-Lymphocyte; Targetings, Gene; Thymus-Dependent Lymphocytes; Vaccines; Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Viral Hepatitis B; Virus Diseases; Virus-HIV; abstracting; base; cytomegalovirus group; expiration; gene expression signature; human cytomegalovirus; human herpesvirus 4 group; human subject; immunogen; improved; inhibitor; inhibitor/antagonist; memory T lymphocyte; mouse model; novel; pathogen; pathway; programs; response; self-renewal; serum hepatitis; social role; thymus derived lymphocyte; transcription factor; transcriptome; vaccination strategy; vertebrata; viral infection; virus infection",Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1,,48785,IHD,Immunity and Host Defense Study Section,,8,413355,
7761276,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI048833-09,,NIAID:402188;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,PATHOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"STERN, LAWRENCE J;",1945948;,5R01AI048833,01/29/2001,01/31/2013,"3-D; 3-Dimensional; APC; ATGN; After Care; After-Treatment; Aftercare; Animal Welfare; Antigen Presentation; Antigen Presentation Pathway; Antigen Processing; Antigen Processing and Presentation; Antigen Processings; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Assay; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bibliography; Binding; Binding (Molecular Function); Binding Determinants; Binetrakin; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cell Maturation; Cell surface; Characteristics; Class II Antigens; Class II Major Histocompatibility Antigens; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; DR1; DR1 gene; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dendritic Cells; Deposit; Deposition; Detection; Development; Direct Costs; Ecological impact; Editorial Comment; Editorial Comment (PT); Employee Strikes; Environment; Environmental Impact; Epitopes; Epitopes, T-Lymphocyte; Equipment; Ethics Committees, Research; Figs; Figs - dietary; Funding; Goals; Grant; HLA-DR1; HLA-DR1 Antigen; Histocompatibility Antigens Class II; I-A Antigen; IACUC; IL-4; IL4; IL4 Protein; IRBs; Ia Antigens; Ia-Like Antigens; Immune; Immune Response Antigens; Immune response; Immune-Response-Associated Antigens; Immunologic Accessory Cells; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin-4; Interleukin-4 Precursor; International; Location; Lymphocyte Stimulatory Factor 1; MCGF-2; MHC Class II Molecule; MHC Class II Protein; MHC antigen; MHC binding peptide; MHC class II antigen; Major Histocompatibility Complex Class II; Mast Cell Growth Factor-2; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monocytes / Macrophages / APC; NC2-Beta; Pathway interactions; Peptide Receptor; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Peptides; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Published Comment; Research; Research Ethics Committees; Research Resources; Resources; Role; Sampling; Solubility; Strikes; Strikes, Employee; Structure; T-Cell Epitopes; T-Cell Growth Factor 2; T-Lymphocyte Epitopes; Veiled Cells; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; accessory cell; antigen processing; base; clinical data repository; clinical data warehouse; conformation; conformational state; data acquisition; data repository; design; designing; experience; experiment; experimental research; experimental study; expiration; functional outcomes; gene product; host response; human subject; immunogen; immunoresponse; interest; novel; pMHC; pathway; programs; quantum; relational database; research study; response; sharing data; social role; vertebrata",Class II MHC Antigen Processing in Dendritic Cells,,48833,CMIA,Cellular and Molecular Immunology - A Study Section,,9,402188,
7767722,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI049187-10,,NIAID:618582;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"JOHNSON, ALEXANDER D;",1887265;,5R01AI049187,03/01/2001,02/28/2011,"Alimentary Canal; Area; Binding; Binding (Molecular Function); C. albicans; C.albicans; Candida; Candida albicans; Cells; Chromans; Collaborations; Digestive Tract; Dihydrobenzopyrans; Environment; Filament; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Targeting; Generalized Growth; Genes; Genetic Screening; Genome; Goals; Growth; Human; Human, General; Immune Precipitation; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunoprecipitation; Immunosuppressed Host; Infection; Knock-out; Knockout; Laboratories; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Molecular; Molecular Interaction; Monilia; Murine; Mus; Organism; Partner in relationship; Pathogenesis; Pattern; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; RNA Splicing; Role; S cerevisiae; Saccharomyces cerevisiae; Scheme; Splicing; Systemic infection; Targetings, Gene; Tissue Growth; Virulence; Yeast, Baker's; Yeast, Brewer's; Yeasts; alimentary tract; base; cell type; design; designing; digestive canal; fitness; immunosuppressed patient; living system; mate; mouse model; ontogeny; pathogen; programs; social role",Regulatory Circuits and Virulence in Candida albicans,,49187,PTHE,Pathogenic Eukaryotes Study Section,,10,618582,
7760856,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI049261-08,,NIAID:376200;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"PHAM, CHRISTINE T;",1890236;,5R01AI049261,04/01/2001,01/31/2013,"ANCA; Acute; Adhesion Molecule; Angiitis; Animal Welfare; Anti-Neutrophil Cytoplasmic Antibody; Antibodies; Antineutrophil Cytoplasmic Antibodies; Attenuated; Azurophil Granule Protein 7; Bibliography; Binding; Binding (Molecular Function); Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; C-ANCA; C-ANCA Antigen; Cathepsin G; Cell Adhesion Molecules; Cell surface; Cells; Cellular Matrix; Chromogenic Substrates; Cleaved cell; Complement; Complement Proteins; Country; Cytokines, Chemotactic; Cytoskeletal System; Cytoskeleton; DIF; Data; Development; Disease; Disorder; Ecological impact; Endothelial Cells; Environment; Environmental Impact; Enzymes; Equipment; Esteroproteases; Ethics Committees, Research; Goals; Hemagglutinating Virus of Japan; Heterophil Granulocyte; Homologous Chemotactic Cytokines; IACUC; INFLM; IRBs; Impact, Environmental; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Influenza D Virus; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; International; Invaded; Kidney; Killings; Learning; Leukocyte Proteinase 3; Lung; Mammals, Mice; Manuscripts; Marrow Neutrophil; Measures; Mediating; Mice; Mice, Mutant Strains; Modeling; Modification; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Myeloblastin; N-proteinase 4; NP-4; NP4(3); Necrotizing Respiratory Granulomatosis; Neutrophil Proteinase 4; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organ; PR-3; Peptidases; Peptide Hydrolases; Physiologic; Physiological; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Proteases; Protein Cleavage; Proteinase 3; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Publications; Receptor Protein; Recruitment Activity; Research; Research Ethics Committees; Research Resources; Resources; Respiratory System, Lung; Role; SIS cytokines; Scientific Publication; Sendai virus; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinase, Neutrophil; Serine Proteinases; Severity of illness; Substrates, Chromogenic; TNF; TNF A; TNF gene; TNFSF2; Tumor Necrosis Factor Gene; Urinary System, Kidney; Vasculitis; Vertebrate Animals; Vertebrates; Viral Diseases; Virus Diseases; Wegener Autoantigen; Wegener Granulomatosis Autoantigen; Wegener's Granulomatosis; abstracting; cell adhesion protein; chemoattractant cytokine; chemokine; cleaved; cytokine; disease severity; disease/disorder; expiration; extracellular; gene product; human subject; in vitro Assay; in vivo; in vivo Model; intracellular skeleton; loss of function mutation; mouse mutant; neutrophil; neutrophil proteinase 3; p29; p29b; pathogen; programs; pulmonary; receptor; recruit; renal; social role; syndecan-4; vertebrata; viral infection; virus infection",ROLE OF DPPI & SERINE PROTEASES IN INFLAMMATORY DISEASES,,49261,III,Innate Immunity and Inflammation Study Section,,8,376200,
7766941,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI049367-09,,NIAID:310845;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LEXINGTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"SINAI, ANTHONY P.;",6628916;,5R01AI049367,03/01/2001,02/28/2011,"Acute; Apoptosis; Apoptosis Pathway; Apoptotic; Arts; Bears; Biochemical Genetics; Biological; Biphasic Pattern; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Complex; Cytoplasm; DISSEC; Data; Defect; Detection; Development; Dissection; EC 2.7; Event; Exhibits; Expression Profiling; Expression Signature; Gene Expression; Generations; Genes; Genetic Screening; Genetic, Biochemical; I Kappa B A; I Kappa B-Alpha; I kappa B kinase; I kappa B-alpha protein; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IkappaB kinase; IkappaBalpha; Immunity; Immunoglobulin Enhancer-Binding Protein; Infection; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Intracellular Communication and Signaling; Isoforms; Kinases; Knock-out; Knockout; Lesion; Link; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Maps; Membrane; Molecular; Molecular Fingerprinting; Molecular Profiling; NF-Kappa B Inhibitor Alpha; NF-kB; NF-kappa B; NF-kappaB; NF-kappaB inhibitor alpha; NFKB; NFKBI; NFKBIA; NK-kappa B-activating kinase NAK; Nature; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Nuclear Transcription Factor NF-kB; Organelles; Parasites; Pathogenesis; Pathway interactions; Phosphorylation; Phosphotransferases; Protein Isoforms; Protein Phosphorylation; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signaling; T. gondii; T. gondii infection; Technology; Toxoplasma gondii; Toxoplasma gondii Infection; Toxoplasmosis; Transcription Factor NF-kB; Transphosphorylases; Ursidae; Ursidae Family; Vacuole; base; biological signal transduction; cultured cell line; cytokine; experiment; experimental research; experimental study; inhibitor; inhibitor/antagonist; kappa B Enhancer Binding Protein; membrane structure; molecuar profile; molecular signature; mutant; nuclear factor kappa beta; p40 protein (IkappaB-alpha); pathogen; pathway; research study; social role; success; transcription factor",Blockade of host apoptosis by Toxoplasma gondii,,49367,PTHE,Pathogenic Eukaryotes Study Section,,9,310845,
7758773,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI050050-09,,NIAID:325744;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"LIU, JIAN NONE;",6718947;,5R01AI050050,07/15/2001,01/31/2011,"2-Amino-2-Deoxyglucose; Address; Alkanesulfonates; Alkyl Sulfonates; Alkylsulfonate Compound; Amino Acids; Anabolism; Anticoagulant Agents; Anticoagulant Drugs; Anticoagulants; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Cell surface; Cell-Extracellular Matrix; Cells; Combining Site; Cornea; D-Glucose, 2-amino-2-deoxy-; Data; EC 2.8.2; ECM; Encephalon; Encephalons; Envelope Protein; Enzymes; Extracellular Matrix; Family; Funding; Gene Products, env; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Glucosamine; Glycans; Glycoproteins; HHV-1; HSV; HSV-1; HSV1; HVEM; Heparan Sulfate; Heparan Sulfate Biosynthesis; Heparin; Heparinic Acid; Heparitin Sulfate; Herpes Simplex; Herpes Simplex Infections; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpes simplex disease; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus hominis; Herpesvirus hominis disease; HevC protein; Human; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; Human, General; In Vitro; Infection; Inorganic Sulfates; Investigators; Isoforms; Lead; Man (Taxonomy); Man, Modern; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Nervous System, Brain; Oligosaccharides; PVRL1; Pathway interactions; Pattern; Pb element; Physiologic; Physiological; Play; Polysaccharides; Programs (PT); Programs [Publication Type]; Protein Isoforms; Prr1 protein; Reactive Site; Receptor Protein; Reporting; Research Personnel; Researchers; Role; Series; Simplexvirus; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Space Perception; Spatial Discrimination; Specificity; Structure; Substrate Specificity; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Targeted DNA Modification; Targeted Modification; Testing; Tissues; Unspecified or Sulfate Ion Sulfates; Viral Diseases; Viral Envelope Proteins; Virus; Virus Diseases; Viruses, General; aminoacid; base; biosynthesis; blood thinner; coat (enveloped virus); corneal; design; designing; env Antigens; env Gene Products; env Polyproteins; env Protein; genome mutation; glycoprotein structure; heavy metal Pb; heavy metal lead; herpes simplex i; herpes virus 1, human; herpesvirus; herpesvirus entry mediator C; high voltage electron microscopy; human alphaherpesvirus 1; human herpesvirus 1 group; human poliovirus receptor related 1; improved; in vivo; member; mimetics; mutant; nectin-1; new approaches; novel approaches; novel strategies; novel strategy; pathway; perceptual spatial orientation; poliovirus receptor-related protein 1; programs; receptor; social role; spatial orientation; spatial orientation (perception); spatial perception; sulfate; sulfonate; sulfotransferase; thrombopoiesis inhibitor; viral infection; virus envelope; virus infection",Structural Specificity of Heparan Sulfate for Herpes Infections,,50050,ZRG1,Special Emphasis Panel,,9,325744,
7777419,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI050243-09,,NIAID:569364;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IRVINE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"YAN, GUIYUN ;",1870273;,5R01AI050243,09/01/2001,02/28/2013,"21+ years old; Adult; Africa; Africa South of the Sahara; African; Age; Anti-malarial drug resistance; Anti-malarial drug resistant; Antibodies; Antimalarial drug resistance; Antimalarial drug resistant; Area; Blood Serum; Breeding; Cessation of life; Characteristics; Climate; Clinical; Cohort Studies; Communities; Concurrent Studies; Country; Culicidae; Data; Death; Depression; Development; Disease Outbreaks; Ecology; Environmental Science; Epidemic; Epidemiology; Exhibits; Falciparum Malaria; Frequencies (time pattern); Frequency; Future; Genetic Models; Genetics, Population; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; Grant; HOSP; Habitats; Hospitals; Human, Adult; Immune; Incidence; Infection; Kenya; Killings; Larva; Life; Malaria; Malaria prevention; Malaria, Falciparum; MeSH Descriptors Class 4; Measures; Mental Depression; Meteorological Climate; Methods; Modeling; Models, Genetic; Models, Statistical; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mosquitoes; Outbreaks; Paludism; Parasites; Pattern; Plasmodium Infections; Plasmodium falciparum Malaria; Play; Population; Population Genetics; Preparedness; Probabilistic Models; Public Health; Readiness; Research; Risk; Role; Scientist; Sea; Seasons; Series; Serum; Site; Spatial Distribution; Statistical Models; Sub-Saharan Africa; Subsaharan Africa; System; System, LOINC Axis 4; Temperature; Testing; Time; Transmission; acquired immunity; adult human (21+); base; climatic; computer based prediction; cost; cost effectiveness; design; designing; geographic site; interest; land cover; land use; novel; predictive modeling; prevent; preventing; prospective; public health medicine (field); public health relevance; resistance to anti-malarial drug; resistance to antimalarial drug; resistant to anti-malarial drug; resistant to antimalarial drug; social role; transmission process; vector control; vector mosquito",Ecology of African Highland Malaria,,50243,CRFS,Clinical Research and Field Studies of Infectious Diseases Study Section,,9,569364,
7763163,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI050265-09,,NIAID:447467;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,603880287,US,CA,92037,LA JOLLA INST FOR ALLERGY & IMMUNOLGY,"CHEROUTRE, HILDE MC;",6725385;,5R01AI050265,07/01/2001,01/31/2011,"Animals; Autoantigens; Autologous Antigens; Bacteria; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Colitis; Communication; Data; Dendritic Cells; Disease; Disorder; Epithelial; Epithelium; Epithelium, Intestinal; Equilibrium; GALT; Gastrointestinal Tract, Small Intestine; Grant; Gut Inflammation; Gut associated lymphoid tissue; Health; Human; Human, General; Immune; Immune Tolerance; Immune response; Immune system; Immunologic Tolerance; In Vitro; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Instruction; Intestinal; Intestinal Inflammation; Intestines; Intestines, Small; Intracellular Communication and Signaling; Knowledge; Lead; Liquid substance; Lymphocyte; Lymphocytic; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medical; Mice; Modeling; Murine; Mus; Nutrient; Organ; Organism; Pb element; Play; Population; Production; Publishing; Regulation; Regulatory T-Lymphocyte; Role; Self-Antigens; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Intestines; Structure of intestinal epithelium; Surface; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Thymus-Dependent Lymphocytes; Time; Transgenic Organisms; Veiled Cells; Vertebrate Animals; Vertebrates; Whole Organism; balance; balance function; base; biological signal transduction; body system, allergic/immunologic; bowel; commensal bacteria; commensal microbes; cytokine; disease/disorder; fluid; heavy metal Pb; heavy metal lead; helper T cell; host response; immune system tolerance; immune unresponsiveness; immunological paralysis; immunoresponse; intestinal epithelium; liquid; living system; lymph cell; organ system, allergic/immunologic; pathogen; prevent; preventing; small bowel; social role; thymus derived lymphocyte; transgenic; uptake; vertebrata",Mucosal immune regulation by CD8aa+ cells,,50265,IHD,Immunity and Host Defense Study Section,,9,447467,
7763818,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI050438-08,,NIAID:347490;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DURHAM,UNITED STATES,GENETICS,04,044387793,US,NC,27705,DUKE UNIVERSITY,"HEITMAN, JOSEPH ;",1890061;,5R01AI050438,07/01/2001,02/28/2013,"2-amino-4-oxobutyric acid; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 5-FC; 5-Fluorocytosine; AIDS; AIDS Virus; ATP[{..}]L-aspartate 4-phosphotransferase; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Alcobon; AmB; Amino Acid Biosynthesis; Amino Acids; Amphocil; Amphotec; Amphotercin B; Amphotercin B Deoxycholate; Amphotericin; Amphotericin B; Anabolism; Ancobon; Ancotil; Animal Model; Animal Models and Related Studies; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antifungal Agents; Antifungal Drug; Antifungal Therapy; Antiretroviral Therapy, Highly Active; Aspartate Kinase; Aspartokinase; Aspartyl Kinase; Aspiration, Respiratory; Azoles; Biological; Biological Factors; Blood Coagulation Factor IV; Breathing; C. albicans; C.albicans; CCI-779; Ca++ element; Calcineurin; Calcineurin antagonist; Calcineurin inhibitor; Calcium; Candida; Candida albicans; Candidate Disease Gene; Candidate Gene; Candidiasis; Candidosis; Cell Communication and Signaling; Cell Cycle Inhibitor 779; Cell Signaling; Cells; Chaperone; Chemicals; Chemistry, Pharmaceutical; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Ciclosporin; Client; Clinical, Transplantation, Organ; Coagulation Factor IV; Combination Chemotherapy Regimen; Combination Drug Therapy; Combined Modality Therapy; Complement; Complement Proteins; Complex; Cryptococcal Meningitis; Cryptococcosis; Cryptococcus neoformans; Cryptococcus neoformans infection; CsA; Cyclophilins; Cyclosporin A; Cyclosporin-Binding Proteins; Cyclosporine; Cyclosporine A; Drug Combinations; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Interactions; Drug Targeting; Drug Targetings; Drug resistance; Drugs; Elements; Enzymatic Biochemistry; Enzymes; Enzymology; Epidemic; Ergosta-5,7,22-trien-3-ol, (3beta,22E)-; Ergosterol; Exhibits; Exposure to; FK 506; FK506; FK506-Binding Protein 1; FK506-Binding Protein 1A; FKBP-12; FKBP12; Factor IV; Factor, Biologic; Feedback; Flucytosine; Formulation; Formulations, Drug; Fungal Meningitis; Fungicides, Therapeutic; Fungizone; Fungus Diseases; Gene Transcription; GeneHomolog; Generalized Growth; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Grafting Procedure; Growth; HAART; HIV; HTLV-III; Highly Active Antiretroviral Therapy; Homolog; Homologous Gene; Homologue; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immune system; Immunologic Deficiency Syndrome, Acquired; Immunosuppressants; Immunosuppressive Agents; Industrial fungicide; Industry; Infection; Infection by Cryptococcus neoformans; Inhalation; Inhaling; Injection of therapeutic agent; Injections; Insecta; Insects; Inspiration, Respiratory; Intracellular Communication and Signaling; Invertebrates, Insects; Killings; L-Methionine; L-Threonine; LAV-HTLV-III; Lead; Lipids; Lymphadenopathy-Associated Virus; Macrophilin-12; Man (Taxonomy); Man, Modern; Medical Device; Medication; Medicinal Chemistry; Meningitis, Cryptococcal; Meningitis, Fungal; Metabolic; Metabolic Pathway; Methionine; Methionine, L-Isomer; Miscellaneous Antibiotic; Modeling; Molecular; Molecular Chaperones; Monilia; Moniliasis; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Mutation; Mycoses; Natural Products; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Oropharyngeal; Oropharynx; Oropharynxs; PP2B; Pathway interactions; Patients; Pb element; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Preparations; Physiologic; Physiological; Play; Polychemotherapy; Procedures; Protein Phosphatase-2B; Proteins; Quimioterapia; RNA Expression; Rapamune; Rapamycin; Rapamycin Analog; Rapamycin Analog CCI-779; Research; Role; S cerevisiae; Saccharomyces cerevisiae; Sandimmun; SangCya; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Site; Steroid Compound; Steroids; Tacrolimus Binding Protein 1A; Tail; Testing; Therapeutic; Therapeutic Agents; Threonine; Tissue Growth; Torulosis; Transcription; Transcription, Genetic; Translations; Transplantation; Transplantation Surgery; Veins; Virus-HIV; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; YeastModel; aminoacid; aminoacid biosynthesis; analog; anti-fungal; anti-retroviral therapy, highly active; antifungals; aspartate semialdehyde; aspartic acid beta-semialdehyde; aspartic beta semialdehyde; aspartic semialdehyde; base; biological signal transduction; biosynthesis; body system, allergic/immunologic; cancer chemotherapy; chemotherapy; combination pharmacotherapy; combination therapy; combined modality treatment; combined treatment; detection of nutrient; drug detection; drug development; drug resistant; drug testing; drug/agent; fluorocytosine; fungal infection; fungicidal; fungicide; fungus; fungus infection; gastrointestinal infection; gene product; genome mutation; heavy metal Pb; heavy metal lead; immunosuppressive; inhibitor; inhibitor/antagonist; insight; inspiration; loss of function mutation; model organism; multimodality therapy; mutant; neoral; new approaches; novel; novel approaches; novel strategies; novel strategy; nutrient sensing; ontogeny; oral pharyngeal; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; pathogen; pathway; perception of nutrients; resistance to Drug; resistant to Drug; sandimmune; social role; structural biology; therapeutic development; transplant; treatment of fungal infectious disease",Novel Antifungal Therapeutic Approaches,,50438,ZRG1,Special Emphasis Panel,,8,347490,
7760865,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI050875-07,,NIAID:391532;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HAMBLIN, MICHAEL R;",6098232;,5R01AI050875,12/01/2001,01/31/2012,"Acute; Animal Experiments; Animal Model; Animal Models and Related Studies; Animal Welfare; Antibiotic Resistance; Aspergillus fumigatus; Bacteria; Bibliography; Binding; Binding (Molecular Function); Body Tissues; Burn injury; Burns; C. albicans; C.albicans; Candida albicans; Cell Wall; Chronic; Coloring Agents; Country; Destinations; Dyes; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Experiments, Animal; Focal Infection; Funding; Generations; Goals; Grant; H2O2; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; IACUC; IRBs; Illumination; Image; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Invaded; Killings; L-Lysine; Lesion; Lighting; Lipids; Lysine; Malignant Cell; Mediating; Methods; Microbe; Modeling; Molecular; Molecular Interaction; Mouse Strains; Nucleic Acids; O element; O2 element; Oxygen; P. aeruginosa; P.aeruginosa; Pathogenicity Factors; Photochemotherapy; Photodynamic Therapy; Photosensitizers; Photosensitizing Agents; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Radiation, Visible; Radiation, Visible Light; Research; Research Ethics Committees; Research Resources; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resources; S. aureus; S.aureus; Staphylococcus aureus; Testing; Tissues; Vertebrate Animals; Vertebrates; Virulence Factors; Visible Light; Visible Radiation; abstracting; amino group; anti-microbial; antibiotic resistant; antimicrobial; cancer cell; cell killing; cell type; chlorin e6; chlorine e6; clinical practice; cytotoxic; expiration; extracellular; fluorescence imaging; fungus; gene product; human subject; imaging; in vivo; infection localized; model organism; mouse model; neoplasm/cancer photoradiation therapy; novel; pathogenic bacteria; programs; vertebrata",Photodynamic Therapy of Localized Infections,,50875,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,7,391532,
7764781,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI050950-05,,NIAID:350460;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"SNAPPER, SCOTT B;",1903801;,5R01AI050950,04/05/2002,01/31/2014,"ATGN; Adoptive Transfer; Affect; Aldrich Syndrome; Animals; Antigens; Arm; Autoimmune Status; Autoimmunity; Automobile Driving; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Blood leukocyte; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Surface Receptors; Cells; Cells, CD4; Cellular Matrix; Cellular Migration; Chronic; Co-Stimulator; Colitis; Costimulator; Cytokine Signal Transduction; Cytokine Signaling; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Data; Defect; Dendritic Cells; Development; Disease; Disorder; Drivings, Automobile; Dysfunction; Epidermal Thymocyte Activating Factor; Extracellular Matrix, Integrins; Functional disorder; Gene Expression; Gene Transcription; Generations; Genes; Genetic; Genetic Transcription; Goals; Hematopoietic; Homing; Human; Human, General; IL-13; IL-2; IL-4; IL13; IL2; IL2 Protein; IL4; IL4 Protein; INFLM; Immune; Immune system; Immunity, Mucosal; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Inflammation; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Integrins; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-13; Interleukin-2; Interleukin-4; Interleukin-4 Precursor; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Investigation; Knockout Mice; Knowledge; Lamina Propria; Lead; Leukocytes; Link; Lymphocyte; Lymphocyte Mitogenic Factor; Lymphocyte Stimulatory Factor 1; Lymphocytic; MCGF-2; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mast Cell Growth Factor-2; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mitogenic Factor; Modeling; Molecular; Motility; Motility, Cellular; Mucosal Immunity; Murine; Mus; Names; Null Mouse; Onset of illness; Pathogenesis; Patients; Pb element; Penetrance; Physiopathology; Population; Protein Deficiency; Proteins; RNA Expression; Receptor Signaling; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Regulation; Regulatory T-Lymphocyte; Relative; Relative (related person); Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Thymus; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; T cell growth factor; T-Cell Growth Factor; T-Cell Growth Factor 2; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Testing; Thymocyte Stimulating Factor; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissues; Transcription; Transcription, Genetic; Upper arm; Veiled Cells; White Blood Cells; White Cell; Wiskott syndrome; Wiskott-Aldrich Syndrome; base; biological signal transduction; body system, allergic/immunologic; cell motility; chemokine receptor; cytokine; design; designing; disease onset; disease/disorder; disorder onset; driving; eczema thromocytopenia diarrhea syndrome; eczema thromocytopenia immunodeficiency syndrome; eczema thromocytopenia syndrome; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; helper T cell; hypoimmunity; immune deficiency disorder; immunodeficiency; immunogen; immunological synapse; imprint; in vivo; intracellular skeleton; lymph cell; migration; mouse model; organ system, allergic/immunologic; pathophysiology; public health relevance; receptor-mediated signaling; research study; self recognition (immune); social role; synapse formation; synaptogenesis; thymus derived lymphocyte; white blood cell; white blood corpuscle",Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis, The overall goal of this proposal is to further our understanding of the regulatory T cell defects and the mechanism of colitis in Wiskott Aldrich Syndrome protein knock-out mice and to take advantage of a model of colitis that also has a human correlate.,50950,GMPB,Gastrointestinal Mucosal Pathobiology Study Section,,5,350460,
7752608,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI051174-09,,NIAID:526404;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,BIOCHEMISTRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"SUNDQUIST, WESLEY IAN;",1864491;,5R01AI051174,02/01/2002,01/31/2012,"3-D structure; 3-dimensional structure; 3D structure; AIDS Virus; APF-1; ATP Hydrolysis; ATP phosphohydrolase; ATP-Dependent Proteolysis Factor 1; ATPase; ATPase Domain; Adenosine Triphosphatase; Adenosinetriphosphatase; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Biochemical; Biochemistry; Cells; Chaperone; Chemistry, Biological; Combining Site; Complex; Enzymes; Family; Gagging; Glues; HIV-1; HIV-I; HIV1; HMG-20; High Mobility Protein 20; Human; Human immunodeficiency virus 1; Human, General; Immunodeficiency Virus Type 1, Human; Individual; Ligand Binding Protein; Man (Taxonomy); Man, Modern; Maps; Membrane; Modeling; Molecular Chaperones; Molecular Interaction; Pathway interactions; Proteins; Reactive Site; Recombinants; Reflex, Pharyngeal; Regulation; Research; Role; Series; Sorting - Cell Movement; Structure; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; TSG10; TSG101; TSG101 gene; Testing; Ubiquitin; VESCL; Vesicle; Virus; Viruses, General; gene product; human T cell leukemia virus III; human T lymphotropic virus III; membrane structure; pathway; protein complex; social role; sorting; three dimensional structure",Biochemistry of HIV-1 Budding,,51174,AMCB,AIDS Molecular and Cellular Biology Study Section,,9,526404,
7765586,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI051454-07,,NIAID:372488;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BURLINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"RINCON, MERCEDES R.;",6704052;,5R01AI051454,06/01/2002,01/31/2014,"Affect; B blood cells; B cell receptor; B-Cell CLL; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Cells; B-Lymphocytes; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; BCR; BCR gene; BCR1; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Cell Communication and Signaling; Cell Cycle Checkpoint; Cell Cycle G2/M Checkpoint; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Oncogene; Chromosomal dislocation; Chromosomal translocation; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; D22S11; D22S662; DNA; DNA Alteration; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Integration; DNA Recombination; DNA Repair; DNA mutation; DNA recombination (naturally occurring); Deoxyribonucleic Acid; Development; Drugs; EC 2.7; EC 2.7.2-; Extracellular Signal-Regulated Kinases; Frequencies (time pattern); Frequency; G2/M Checkpoint Pathway; Gene Alteration; Gene Mutation; Generations; Genetic Recombination; Genetic mutation; Genome; Genome Instability; Genome Stability; Genomic Instability; Immunoglobulin V(D)J Rearrangement; In Vitro; Infant; Intracellular Communication and Signaling; Kinases; Leukemia, B-Cell; Lymphoblastic Leukemia, Chronic; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; MAP kinase; MAPK; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Neoplasms; Malignant Tumor; Mediating; Medication; Mitogen-Activated Protein Kinases; PHL; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphorylation; Phosphotransferases; Play; Predisposition; Prevention; Process; Protein Phosphorylation; Proto-Oncogenes; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Recombination; Recombination, Genetic; Reticuloendothelial System, Thymus; Role; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Stability, Genomic; Stimulus; Stress; Susceptibility; System; System, LOINC Axis 4; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; Thymocyte Development; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Translocation, Genetic; Transphosphorylases; Unscheduled DNA Synthesis; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; biological signal transduction; c-ONC; chromosome dislocation; chromosome translocation; chronic lymphoid leukemia; clinical investigation; cytokine; drug/agent; hazard; in vivo; inhibitor; inhibitor/antagonist; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; irradiation; malignancy; mitogen-activated protein kinase p38; necrocytosis; neoplasm/cancer; p38 MAP Kinase; p38 MAPK; p38 Protein Kinase; p38 SAPK; pathway; prevent; preventing; protooncogene; public health relevance; repair; repaired; response; social role; thymocyte; thymus derived lymphocyte",p38 MAP kinase in early thymocyte development," Project Narrative  DNA damage and genomic instability are clearly associated with the development of malignancies. To prevent genomic instability, cells normally undergo cell cycle checkpoints (G1/S and G2/M checkpoints) that delay the normal cycle to allow time for DNA repair to occur. Although UV and ionizing irradiation as well as chemotherapeutic drugs are the major inducers of DNA damage, genomic instability is continuously present in developing T and B cells while undergoing recombination of their corresponding T cell receptor (TCR) or BCR genes. During this process, denominated V(D)J recombination, fragments of DNA with non-protected double stranded breaks (signal ends) are excised from the genome. These signal end DNA fragments can be a hazard for T and B cells since they can attack other duplex DNA and can randomly integrate into the genome, causing potential malignancies. The frequency of T and B cell leukemias is relatively high and often these malignancies have been associated with chromosomal translocations, deletions and insertions that affect the expression or activity of specific proto-oncogenes. The establishment of checkpoints during the generation of T and B cell receptors is therefore important to maintain genomic stability. We propose to investigate the role that the p38 MAP kinase pathway has in preventing integration in the genome of signal ended fragments resulting from TCRb V(D)J recombination in immature thymocytes (DN3 thymocytes), by promoting the induction of a cell cycle checkpoint (primarily G2/M) and also providing survival. Pharmaceutical inhibitors of the p38 MAPK pathway are currently in clinical trials. If our hypothesis is correct, these inhibitors should be avoided primarily in infants where T cell development is highly active. In addition, genetic mutations that may affect this pathway could determine a relatively higher susceptibility to develop T cell malignancies.",51454,CMIB,Cellular and Molecular Immunology - B Study Section,,7,372488,
7769931,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI051517-07,,NIAID:294030;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LEXINGTON,UNITED STATES,BIOCHEMISTRY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"DUTCH, REBECCA E.;",8110859;,5R01AI051517,05/15/2002,01/31/2014,"Address; Affect; Alanine; Alanine, L-Isomer; Aminoacetic Acid; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; CATL; CTSL Protein; Cathepsin L; Cell fusion; Cell membrane; Cells; Charge; Chimera Protein; Chimeric Proteins; Cleaved cell; Cysteine; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Data; Development; EC 3.4.22.15; Electrostatics; Endocytosis; Equine Morbillivirus; Esteroproteases; Event; Family; Family member; Funding; Fusion Protein; Genetic Alteration; Genetic Change; Genetic defect; Glycine; Glycoproteins; Goals; Half-Cystine; Hendra Virus; Human; Human Metapneumovirus; Human respiratory syncytial virus; Human, General; Integral Membrane Protein; Intrinsic Membrane Protein; Kinetic; Kinetics; L-Alanine; L-Cysteine; L-Proline; Lead; Major Excreted Protein; Man (Taxonomy); Man, Modern; Measles virus; Mediating; Membrane Fusion; Molecular; Mutation; Nipah Virus; Paramyxovirus; Pb element; Peptidases; Peptide Hydrolases; Peptides; Plasma Membrane; Play; Position; Positioning Attribute; Process; Proline; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Reagent; Recombinants; Recycling; Research; Respiratory syncytial virus; Role; Route; Scanning; Staging; Structure; System; System, LOINC Axis 4; TM Domain; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Variant; Variation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; cleaved; gene product; genome mutation; heavy metal Pb; heavy metal lead; insight; mutant; novel; parainfluenza virus; pathogen; plasmalemma; protein activation; protein folding; public health relevance; recombinant virus; rougeole virus; rubeola virus; social role; trafficking; treatment of viral infectious disease; virus protein",Paramyxovirus F protein mediated membrane fusion," Relevance: The paramyxovirus family contains both established human pathogens, such as measles virus and respiratory syncytial virus, and newly emerged human pathogens, including the highly pathogenic Hendra and Nipah viruses and the recently identified human metapneumovirus (HMPV). A detailed understanding of the fusion mechanism could lead to development of new antiviral reagents.",51517,ZRG1,Special Emphasis Panel,,7,294030,
7767698,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI051575-07,,NIAID:389087;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ALBUQUERQUE,UNITED STATES,PATHOLOGY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"WILSON, BRIDGET S;",1897766;,5R01AI051575,04/01/2002,01/31/2014,"1H-Imidazole-4-ethanamine; ATGN; Actins; Affinity; Allergens; Allergic Disease; Allergic inflammation; Antibodies; Antigens; Assay; Basophilic Granulocyte; Basophilic Histiocyte; Basophilic Leukocyte; Basophilic leukemia; Basophils; Basophils, Tissue; Behavior; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood Basophil; CD 23 Antigens; CD23 Antigens; Capsid Proteins; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Membrane Lipids; Cell Signaling; Cell membrane; CellLine; Cells; Cellular Matrix; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clathrin; Clathrin Heavy Chains; Clostridium perfringens theta-toxin; Coat Proteins; Color; Common Rat Strains; Complement; Complement Proteins; Complex; Confocal Microscopy; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; DNA Molecular Biology; Diffusion; Electron Microscopy; Elements; Endocytosis; Endocytosis Pathway; Endocytotic role of NDK, Phosphins and Dynamin; Event; Exocytosis; Histamine; IgE; IgE Receptors; Image; Immobilization; Immune; Immune system; Immunoglobulin E; Immunoglobulin E Receptor; Inflammation Mediators; Intracellular Communication and Signaling; Island; Isoforms; Kinetic; Kinetics; Label; Leukotrienes; Life; Lipid Rafts, Cell Membrane; Lipids; Mammals, Rats; Maps; Marrow Basophil; Marrow Mast Cell; Math Models; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Lipids; Membrane Microdomains; Membrane Protein Traffic; Membrane Proteins; Membrane Traffic; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Confocal; Model System; Modeling; Models, Biologic; Molecular; Molecular Biology; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Movement; Nature; Pathway interactions; Peptide Domain; Perfringolysin O; Phosphatides; Phospholipids; Plasma Membrane; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Production; Property; Property, LOINC Axis 2; Protein Domains; Protein Isoforms; Proteins; Proteomics; Q-Dot; Quantum Dots; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Racial Segregation; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Rat; Rattus; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, IgE; Regulation; Relative; Relative (related person); Residencies; Resolution; Roentgen Rays; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small G-Proteins; Small GTPases; Spectrin; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Surface Proteins; Techniques; Tertiary Protein Structure; Testing; Time; Transfection; Transmission; United States; VESCL; Vesicle; Viral Coat Proteins; Viral Outer Coat Protein; Work; X-Radiation; X-Rays; Xrays; allergic response; base; biological signal transduction; body movement; body system, allergic/immunologic; calcium flux; calcium mobilization; cell imaging; cell type; cellular imaging; computerized data processing; cross-link; crosslink; cultured cell line; cytokine; data processing; desensitization; epsilon Fc Receptors; gene product; imaging; immobilization of body part; immunogen; innovate; innovation; innovative; insight; intracellular skeleton; lipid raft; mast cell; mastocyte; mathematical model; mathematical modeling; membrane structure; mutant; nano probe; nanoprobe; novel; organ system, allergic/immunologic; orthopedic freezing; particle; pathway; pfoA gene product, C perfringens; plasmalemma; protein distribution; public health relevance; receptor; receptor internalization; receptor-mediated signaling; release of sequestered calcium ion into cytoplasm; response; segregation; signal processing; social role; theta hemolysin; theta-toxin, C perfringens; transmission process; uptake",Mapping for Specialized Domains for FCeRI Signaling & Internalization," PROJECT NARRATIVE Allergic diseases are on the rise in the United States. Mast cells and basophils are the principal mediators of the allergic response, through activation of the high affinity IgE receptor, Fc¨RI. When these receptors are crosslinked by polyvalent allergens, the cells release inflammatory mediators such as histamine and leukotrienes. We use sophisticated microscopy techniques and analytical approaches to study the behavior of IgE receptors in the mast cell membrane. We have discovered that the plasma membrane has a rich topography, that we believe is critical to the regulation of mast cell responses. The landscape of the mast cell membrane undergoes dramatic change during cell activation and receptors come together into large clusters in order to signal to the cell interior. The signaling process is limited in part by uptake of the receptors into the cell, a process referred to as endocytosis. In this proposal, we will study the dynamic behavior of receptors in live cell membranes using brightly fluorescent nanoprobes called quantum dots. We will also use our innovative electron microscopy methods to map the distributions of lipids, receptors and other proteins across the mast cell landscape. We will gain important insight into the mechanisms that drive receptor endocytosis. Our work is applicable to other cell types, particularly other cells of the immune system. Results of these analyses will contribute important new insight into the nature and assembly of membrane microdomains controlling immune cell signaling.",51575,CMIA,Cellular and Molecular Immunology - A Study Section,,7,389087,
7754655,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI051626-08,,NIAID:432242;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,UNIVERSITY PARK,UNITED STATES,VETERINARY SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"AUGUST, AVERY ;",1925650;,5R01AI051626,12/01/2002,01/31/2013,"ATP[{..}]protein-tyrosine O-phosphotransferase; Acidophilic Leukocyte; Affect; African American; Afro American; Afroamerican; Airway Hyper-responsiveness; Allergic asthma; Allergy; Asthma; Behavioral; Black Populations; Black or African American; Blood Eosinophil; Blood Serum; Bronchial Asthma; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Complex; Data; Developing Countries; Developing Nations; Development; Disease; Disease Progression; Disorder; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Economics; Environmental Factor; Environmental Risk Factor; Eosinophilic Granulocyte; Eosinophilic Leukocyte; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial; Event; Extrinsic asthma; Family; Genetic; Goals; HEK3; Health; Hispanic Populations; Hispanics; Hispanics or Latinos; Human; Human, General; Hypersensitivity; IFN; IgE; Immunoglobulin E; Interferons; Intracellular Communication and Signaling; Kinases; Knowledge; Latino Population; Leiomyocyte; Less-Developed Countries; Less-Developed Nations; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Methods; Mice; Motility; Motility, Cellular; Mucous body substance; Mucus; Murine; Mus; Myocytes, Smooth Muscle; PTK; Pathology; Pathway interactions; Patients; Phosphotransferases; Play; Predisposition; Prevalence; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Regulation; Respiratory System, Lung; Rlk protein; Role; Serum; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spanish Origin; Subcellular Process; Susceptibility; System; System, LOINC Axis 4; T-Cell Activation; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-cell-restricted tyrosine kinase Txk; TEC Protein Tyrosine Kinase; Tec PTK; Tec kinase; Tec tyrosine kinase; Testing; Th-2 Cell; Th2 Cells; Third-World Countries; Third-World Nations; Thymus-Dependent Lymphocytes; Transphosphorylases; Txk tyrosine kinase; Type 2 Helper Cell; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Under-Developed Countries; Under-Developed Nations; Work; airway epithelium infalmmation; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway inflammation; allergic airway epithelium inflammation; allergic airway inflammation; atopic asthma; biological signal transduction; black American; cell motility; chemokine receptor; cytokine; design; designing; disease severity; disease/disorder; environmental risk; eosinocyte; eosinophil; experiment; experimental research; experimental study; extrinsic allergic asthma; hispanic community; hydroxyaryl protein kinase; inner city; innovate; innovation; innovative; molecular pathology; mucous; mutant; pathway; prevent; preventing; programs; pulmonary; receptor function; research study; response; social role; thymus derived lymphocyte; tyrosyl protein kinase",Role of the Tyrosine Kinase ITK in Experimental Allergic Asthma,,51626,ZRG1,Special Emphasis Panel,,8,432242,
7758256,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI052051-08,,NIAID:383127;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,ANATOMY/CELL BIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"HOPE, THOMAS ;",8660826;,5R01AI052051,04/01/2002,01/31/2012,"AIDS; AIDS Virus; AIDS Virus Receptors; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Biology; Blood monocyte; C-C CKR-5 Gene; C-C Chemokine Receptor Type 5 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCR-5 Gene; CCR5; CCR5 gene; CD195 Antigen Gene; CD209; CD209 gene; CD34; CD34 gene; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CDSIGN; CHEMR13 Gene; CKR-5 Gene; CKR5 Gene; CMKBR5 Gene; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Calcium Ion Signaling; Calcium Signaling; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell Surface Proteins; Cell physiology; Cell surface; Cells; Cells, CD4; Cellular Function; Cellular Membrane; Cellular Physiology; Cellular Process; Cellular biology; Chemistry, Biological; Chemokine (C-C) Receptor 5 Gene; Chimera Protein; Chimeric Proteins; Clinic; D2S201E; DC-SIGN; DC-SIGN1; DNA Molecular Biology; Dendritic Cells; Development; Endocytosis Pathway; Endocytotic role of NDK, Phosphins and Dynamin; Event; Exocytosis; FB22; Funding; Fusion Protein; Genital; Genital system; HIV; HIV Infections; HIV Receptors; HIV envelope protein; HIV-1 Fusion Co-Receptor Gene; HM89; HPCA1; HSY3RR; HTLV-III; HTLV-III Infections; HTLV-III Receptors; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Image; Immunologic Deficiency Syndrome, Acquired; Individual; Infection; Intracellular Communication and Signaling; Killings; LAP3; LAV-HTLV-III; LCR1; LESTR; Laboratories; Langerhans cell; Lead; Life; Lymphadenopathy-Associated Virus; Marrow monocyte; Mediating; Methods; Microscopy; Molecular Biology; Molecular Interaction; Mucosa; Mucosal Tissue; Mucous Membrane; Myelogenous; Myeloid; NPY3R; NPYR; NPYRL; NPYY3R; Pathogenesis; Pathway interactions; Pb element; Process; Proteins; Proteins, Cell Surface; Receptor Protein; Receptors, HIV; Role; Sexual Transmission; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Subcellular Process; Surface; Synapses; Synaptic; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Technology; Thymus-Dependent Lymphocytes; Time; Transmission, Sexual; Veiled Cells; Viral; Viral Diseases; Viral Envelope Proteins; Virion; Virus; Virus Diseases; Virus Particle; Virus-HIV; Viruses, General; biological signal transduction; cell biology; design; designing; fight against; gene product; heavy metal Pb; heavy metal lead; helper T cell; imaging; insight; membrane activity; microbicidal; microbicide; monocyte; mucosal vaccine; novel; pathway; receptor; response; social role; thymus derived lymphocyte; trafficking; urogenital system (genital part); viral infection; virus infection",Cell Biology and HIV Entry,,52051,ZRG1,Special Emphasis Panel,,8,383127,
7761762,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI052148-07,,NIAID:377561;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"DARWIN, ANDREW J.;",6953183;,5R01AI052148,07/01/2002,01/31/2014,"Active Follow-up; Address; Affect; Area; Attention; Awareness; Awarenesses; Bacteria; Bacteriophages; Biochemical; Biological Terrorism; Bioterrorism; Cell Communication and Signaling; Cell Fractionation; Cell Membrane Permeability; Cell Signaling; Cell membrane; Circulatory Collapse; Complex; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Disease; Disorder; E coli; Escherichia coli; Future; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gene Expression; Genes; Heart; Human; Human, General; Immunoblotting; In Vitro; Infection; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Investigation; Laboratories; Link; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Potentials; Mice; Modeling; Murine; Mus; Mutagenesis, Site-Directed; P. pseudotuberculosis; Pasteurella pestis; Pasteurella pseudotuberculosis; Pathogenesis; Phages; Physiologic; Physiological; Plague; Plasma Membrane; Play; Position; Positioning Attribute; Production; Proteins; Proton-Motive Force; Regulation; Research; Resting Potentials; Role; Secretin; Shock; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Stress; Symptoms; System; System, LOINC Axis 4; TM Domain; Targeted DNA Modification; Targeted Modification; Testing; Toxic effect; Toxicities; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Translating; Translatings; Transmembrane Domain; Transmembrane Potentials; Transmembrane Protein; Transmembrane Region; Two Hybrid; Virulence; Work; Y. enterocolitica; Y. pestis; Y. pseudotuberculosis; Y.enterocolitica; Y.pestis; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yersinia; Yersinia enterocolitica; Yersinia pestis; Yersinia pestis disease; Yersinia pseudotuberculosis; bacterial virus; base; biological adaptation to stress; biological signal transduction; cell envelope; circulatory shock; design; designing; disease/disorder; follow-up; gastrointestinal disorder; gene product; human disease; insight; language translation; membrane permeability; membrane structure; mutant; new therapeutics; next generation therapeutics; novel therapeutics; plasmalemma; pore forming protein; porin; prevent; preventing; protein protein interaction; public health relevance; reaction; crisis; response; social role; stress response; stress; reaction; subcellular fractionation; yeast two hybrid system",The Psp response of Yersinia enterocolitica," PROJECT NARRATIVE The bacterium Yersinia enterocolitica causes human gastroenteritis, and is closely related to the causative agent of Plague, Y. pestis. The proposed research will increase our understanding of a stress-response system in Y. enterocolitica that is essential for its ability to cause disease, and is also present in numerous other medically important bacteria. Understanding this stress-response system is vital, because in the long-term it could be a target for the design of new therapeutic strategies against Yersinia species as well as other disease- causing bacteria.",52148,BACP,Bacterial Pathogenesis Study Section,,7,377561,
7760154,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI052151-07,,NIAID:336597;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ITHACA,UNITED STATES,NUTRITION,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"BOOR, KATHRYN J;",1927174;,5R01AI052151,08/01/2002,01/31/2013,"Active Follow-up; Alimentary Canal; Animal Welfare; Award; Bibliography; Biological Models; Cessation of life; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communities; Complex; Country; Critiques; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Development; Digestive Tract; Disease; Disorder; Ecological impact; Editorial Comment; Editorial Comment (PT); Electronics; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Food; Funding; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Transcription; Generations; Genes; Genetic Transcription; Genetics-Mutagenesis; Goals; Grant; Hand; IACUC; IRBs; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; L. monocytogenes; Libraries; Listeria; Listeria monocytogenes; Manuscripts; Model System; Models, Biologic; Molecular Biology, Mutagenesis; Mutagenesis; Mutate; NIH; National Institutes of Health; National Institutes of Health (U.S.); Outcome; Peer Review; Phenotype; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Progress Reports; Public Health; Publications; Published Comment; Publishing; RNA Expression; Regulatory Element; RegulatoryElement; Regulon; Relative; Relative (related person); Reports, Progress; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Scientific Publication; System; System, LOINC Axis 4; Testing; Transcription; Transcription, Genetic; Transmission; United States National Institutes of Health; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Virulence; Work; abstracting; alimentary tract; base; biological adaptation to stress; clinical data repository; clinical data warehouse; data repository; digestive canal; disease/disorder; experiment; experimental research; experimental study; expiration; follow-up; food born pathogen; food borne pathogen; food-born; food-borne; foodborn; foodborn pathogen; foodborne; foodborne pathogen; human disease; human subject; mutant; null mutation; programs; public health medicine (field); reaction; crisis; relational database; research study; response; stress response; stress; reaction; transmission process; vertebrata",Regulatory networks contributing to L. monocytogenes transmission and virulence,,52151,BACP,Bacterial Pathogenesis Study Section,,7,336597,
7758292,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI052157-08,,NIAID:381407;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,AURORA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"TORRES, RAUL MARTIN;",1951723;,5R01AI052157,08/01/2002,01/31/2013,"ATGN; Address; Adhesions; Animal Welfare; Antibody Formation; Antibody Production; Antibody Response; Antigen Receptors; Antigens; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; Bibliography; Biochemical Genetics; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Adhesion; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Adhesion; Cellular Migration; Cellular biology; Chemoattractant Receptor; Chemoattractants; Chemotactic Factors; Chemotactic Peptide Receptor; Chemotaxins; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Coupled; Data; Development; Ecological impact; Edg Receptors; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Equipment; Ethics Committees, Research; F-Chemotactic Peptide Receptor; FMLP Receptor; FPR1; Figs; Figs - dietary; Formyl Peptide Receptor 1; Frequencies (time pattern); Frequency; Future; Genetic, Biochemical; Goals; Humoral Immunities; IACUC; IRBs; Immunities, Humoral; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; LPA Receptors; Left; Ligands; Lymphocyte; Lymphocytic; Lysophosphatidic Acid Receptors; Lysophosphatidic Acids; Lysophospholipids; Marrow; Mature B-Cell; Mature B-Lymphocyte; Molecular; Motility; Motility, Cellular; Movement; N-Formylmethionyl Peptide Receptor; N-formyl Hexapeptide Receptor; Nature; Outcome; Peripheral; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; Receptor Signaling; Receptors, Antigen; Receptors, Formyl Peptide; Receptors, Lysophosphatidic Acid; Regulation; Reproducibility; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Spleen; S1P Receptor; S1P1 Receptor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Sphingosine-1-Phosphate Receptor; Spleen; TLR protein; TXT; Text; Toll-like receptors; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; antibody biosynthesis; antibody-based immunity; biological signal transduction; body movement; cell biology; cell motility; complement chemotactic factor; edg-1 Protein; edg-1 Receptor; experiment; experimental research; experimental study; expiration; extracellular; fMet-Leu-Phe receptor; human subject; immunogen; immunoglobulin biosynthesis; in vitro Model; in vivo; interest; lymph cell; migration; mouse model; pathogen; programs; research study; response; thymocyte; vertebrata",Antigen and Chemoattractant Receptor Signaling in B Cell Biology,,52157,CMIB,Cellular and Molecular Immunology - B Study Section,,8,381407,
7758345,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI052468-08,,NIAID:405900;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"HUANG, SHAU-KU ;",1871412;,5R01AI052468,07/01/2003,01/31/2013,"0-11 years old; African American; Afro American; Afroamerican; Allergens; Allergic; Allergic Disease; Allergic asthma; Allergy; Allergy, Food; Asians; Assay; Asthma; Asthma in Children; Bioassay; Biologic Assays; Biological Assay; Black Populations; Black or African American; Bronchial Asthma; C Type Lectin Receptors; Candidate Disease Gene; Candidate Gene; Causality; Chemoattractant Receptor; Chemotactic Peptide Receptor; Child; Child Youth; Childhood Asthma; Children (0-21); Chinese; Chinese People; Chromosome 11; Chromosomes, Human, Pair 11; Clara cell; Complex; Development; Disease; Disorder; Doctor of Philosophy; Etiology; Exons; Extrinsic asthma; F-Chemotactic Peptide Receptor; FMLP Receptor; FPR1; Family; Food Hypersensitivity; Formyl Peptide Receptor 1; Functional RNA; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genome; Grant; Haplotypes; Human; Human, Child; Human, General; Hypersensitivity; IgE; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunogenetic; Immunogenetics; Immunoglobulin E; Immunomodulators; In Vitro; Incidence; Infant; Inherited Predisposition; Inherited Susceptibility; Investigators; Japanese; Japanese Population; Location; Lung; Man (Taxonomy); Man, Modern; Maps; Molecular; Molecular Genetic; Molecular Genetics; N-Formylmethionyl Peptide Receptor; N-formyl Hexapeptide Receptor; Natural Immunity; Non-Coding; Non-Coding RNA; Nonciliated Bronchiolar Epithelial Cell; Parents; Pediatric asthma; Ph.D.; PhD; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Predisposition gene; Programs (PT); Programs [Publication Type]; Proteins; Publishing; Receptor Gene; Receptor Protein; Receptors, C Type Lectin; Receptors, Formyl Peptide; Recruitment Activity; Regulation; Research Personnel; Researchers; Respiratory System, Lung; SEQ-AN; Scanning; Screening procedure; Sequence Analyses; Sequence Analysis; Series; Severities; Steroid Compound; Steroids; Susceptibility; Susceptibility Gene; Tandem Repeat Sequences; Tandem Repeats; Testing; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Variant; Variation; Variation (Genetics); allelic variant; analytical tool; association test; atopic asthma; base; black American; case control; children; cohort; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; extrinsic allergic asthma; fMet-Leu-Phe receptor; gene product; genetic association; genetic etiology; genetic mechanism of disease; genetic variant; genetic vulnerability; host response; human subject; immunoresponse; in vitro activity; in vivo; mannose receptor; member; mouse model; novel; oriental; polymorphism; predisposing gene; programs; pulmonary; receptor; recruit; response; screening; screenings; transcription factor; youngster",Immunogenetic Analysis of Human Immune Response to Allergens,,52468,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,8,405900,
7749525,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI052845-09,,NIAID:335699;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BUSHMAN, FREDERIC D;",6078469;,5R01AI052845,06/01/2002,01/31/2013,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Applications Grants; Area; Binding; Binding (Molecular Function); Binding Proteins; Bio-Informatics; Bioinformatics; Cell Cycle Progression; Cells; Chimera; Chimera organism; Chromatin Structure; Chromosomes; Code; Coding System; Complementary DNA; Complex; DNA; DNA Integration; DNA Methylation; DNA, Complementary; Data; Data Set; Dataset; Deoxyribonucleic Acid; Elements; Funding; Gene Products, RNA; Gene Transcription; Genetic Transcription; Genome; Genome, Human; Genomics; Goals; Grant Proposals; Grants, Applications; HIV; HIV Integrase; HIV Integration Protein; HTLV-III; Histones; Human Genome; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Integrase; LAV-HTLV-III; Laboratories; Ligand Binding Protein; Lymphadenopathy-Associated Virus; Methods; Modeling; Modification; Molecular Interaction; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Publishing; RNA; RNA Expression; RNA, Non-Polyadenylated; Research Resources; Resources; Retroviridae; Retroviruses; Ribonucleic Acid; Role; Route; Site; Specificity; Systems Integration; Time; Transcription; Transcription, Genetic; Virus-HIV; Virus-Retrovirus; abstracting; cDNA; design; designing; experiment; experimental research; experimental study; gene product; improved; in vivo; inhibitor; inhibitor/antagonist; interest; p75; p75 transcription factor; research study; social role; transcriptional coactivator p75; treatment of viral infectious disease",Favored sites for HIV cDNA integration in the human genome,,52845,AMCB,AIDS Molecular and Cellular Biology Study Section,,9,335699,
7765487,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI053193-07,,NIAID:492596;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"RIDDELL, STANLEY R;",2187216;,5R01AI053193,01/21/2003,01/31/2014,"1, 2-Dehydrocortisone; 2'-Nor-2'-deoxyguanosine; 2'NDG; 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Adrenal Cortex Hormones; Affect; Allogenic; Alternative Therapies; Antiviral Agents; Antiviral Drugs; Antivirals; Blood Precursor Cell; CD8; CD8B; CD8B1; CD8B1 gene; CMV; Cancers; Cell Communication and Signaling; Cell Signaling; Cell Therapy; Cells; Clinical Trials; Clinical Trials, Unspecified; Clinical, Transplantation, Organ; Corticoids; Corticosteroids; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; DHPG; Dehydrocortisone; Delta(1)-Cortisone; Deltacortisone; Deltadehydrocortisone; Development; Disease; Disorder; Drug Therapy; Engineering; Engineerings; Funding; GVHD; Ganciclovir; Gancyclovir; Genome; Glucocorticoid Receptor; Glucocorticoids; Graft-Versus-Host Disease; Graft-vs-Host Disease; Grafting Procedure; HCMV; HSC transplantation; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Homologous Wasting Disease; Human; Human, General; ITX; Immunity; Immunobiology; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologically Directed Therapy; Immunophysiology; Immunosuppressed Host; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Immunotherapy; Immunotherapy, Adoptive; In Vitro; Incidence; Inclusion Disease; Individual; Intracellular Communication and Signaling; Knock-out; Knockout; LYT3; Life; Macaca; Macaque; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Memory; Metacortandracin; Method LOINC Axis 6; Methodology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myelosuppression; Natural immunosuppression; Nordeoxyguanosine; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Patients; Pharmacotherapy; Phenotype; Prednisone; Prednisonum; Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-; Progenitor Cell Transplantation; Progenitor Cells, Hematopoietic; Property; Property, LOINC Axis 2; Receptor Gene; Receptor Signaling; Resistance; Risk; Runt Disease; Safety; Salivary Gland Virus Disease; Salivary Gland Viruses; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Specificity; Stem Cell Transplantation; Stem cell transplant; T memory cell; T-Cells; T-Lymphocyte; Testing; Therapeutic Corticosteroid; Therapeutic Glucocorticoid; Therapy, Cell; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Transplant Recipients; Transplantation Surgery; Virus Replication; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adoptive cell immunotherapy; biological signal transduction; cell engineering; cell-based therapy; cellular engineering; clinical investigation; cytomegalovirus group; delta-Cortisone; disease/disorder; human cytomegalovirus; immune therapy; immunosuppressed; immunosuppressed patient; immunosuppression; in vivo; insight; malignancy; memory T lymphocyte; neoplasm/cancer; non-human primate; nonhuman primate; nuclease; organ allograft; organ graft; organ xenograft; prevent; preventing; prophylactic; public health relevance; receptor function; resistant; response; thymus derived lymphocyte; transplant patient; virus multiplication",CD8+ T Cell Immunity to Cytomegalovirus," Project Narrative: Cytomegalovirus infection is a major cause of morbidity and mortality in patients who undergo allogeneic hematopoietic stem cell transplantation and require systemic corticosteroids to treat graft versus host disease. Studies supported by this project have investigated the immunobiology of CMV infection in immunodeficient transplant recipients, and developed adoptive immunotherapy with CMV-specific T cells to restore protective immunity. The proposed studies will investigate the potential for adoptively transferred CMV- specific CD8+ T cells that have been selected for the ability to establish long-lived memory cells and edited at the glucocorticoid receptor gene using zinc finger nucleases to establish durable T cell immunity that is resistant to the immunosuppressive effects of glucocorticoids.",53193,TTT,"Transplantation, Tolerance, and Tumor Immunology",,7,492596,
7759604,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI053439-07,,NIAID:393481;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,PATHOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"KARANDIKAR, NITIN J;",6719328;,5R01AI053439,07/01/2003,01/31/2012,"Address; Area; Biology; CD8; CD8B; CD8B1; CD8B1 gene; Cells; Copaxone; Data; Drugs; FDA approved; Funding; Grant; Immune; Immunologic, Immunochemical; Immunologics; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunomodulation; Immunotherapeutic agent; LYT3; Left; Manuscripts; Mediating; Medication; Methods and Techniques; Methods, Other; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pathway interactions; Patients; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Publications; Publishing; Reports, Progress; Role; Scientific Publication; T-Cells; T-Lymphocyte; Techniques; Thymus-Dependent Lymphocytes; United States National Institutes of Health; clinical effect; drug/agent; immune modulation; immunologic preparation; immunologic reactivity control; immunoregulation; immunotherapeutics; insight; novel; pathway; programs; response; social role; thymus derived lymphocyte",ROLE OF T CELLS IN THE IMMUNE MODULATION OF MS,,53439,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,7,393481,
7763881,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI053531-07,,NIAID:411328;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,UNIVERSITY PARK,UNITED STATES,BIOCHEMISTRY,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"CAMERON, CRAIG E.;",1874615;,5R01AI053531,07/01/2003,01/31/2013,"Achievement; Achievement Attainment; Base Sequence; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Cells; Chemistry, Biological; Coatomer-Coated Vesicles; Collaborations; Complement; Complement Proteins; Complex; Coxsackie Viruses; Coxsackievirus; D-dimer; D-dimer fibrin; D-dimer fragments; DNA Molecular Biology; Development; Electron Microscopy; Elements; Family Picornaviridae; Fibrin fragment D; Foot-and-Mouth Disease Virus; Fostering; Funding; Gene Products, RNA; Genome; Goals; Grant; Human; Human, General; In Vitro; In element; Indium; Kinetic; Kinetics; Laboratories; Lead; Man (Taxonomy); Man, Modern; Membrane; Methods; Modeling; Models, Structural; Molecular; Molecular Biology; Molecular Genetic; Molecular Genetics; Molecular Interaction; Myelin Basic Protein P2; Myelin P2 Protein; NMR Spectroscopy; Nucleotide Sequence; Ohio; P2 Protein; Pb element; Picornaviridae; Picornaviridae Infections; Picornavirus Infections; Picornaviruses; Position; Positioning Attribute; Production; Programs (PT); Programs [Publication Type]; Proteins; Public Health; RNA; RNA chemical synthesis; RNA synthesis; RNA, Non-Polyadenylated; RNA, Viral; Recruitment Activity; Research; Rhinovirus; Ribonucleic Acid; Solutions; Specificity; Spectroscopy, NMR; Structural Models; Structure; Surface; Technology; Testing; Translations; Universities; VPg, poliovirus; Vaccines; Variant; Variation; Vesicles, COPI-Coated; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus Diseases; Viruses, General; base; computational studies; computer studies; experiment; experimental research; experimental study; fibrin fragment D-dimer; fibrin fragment D1 dimer; fibrin fragment DD; gene product; genetic element; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; membrane structure; novel; nuclear magnetic resonance spectroscopy; nucleic acid sequence; poliovirus VPg; positional cloning; programs; public health medicine (field); public health relevance; reconstitute; reconstitution; recruit; research study; reverse genetics; stem; stoichiometry; tool; trafficking; viral RNA; viral infection; virus RNA; virus infection; virus protein",Picornavirus Genome Replication," Project Narrative Picornaviruses represent an existing and emerging threat to US public health. Achievement of the goals of the application will provide novel targets and mechanisms for development of inhibitors to treat infections by picornaviruses, especially those for which vaccines are not available.",53531,ZRG1,Special Emphasis Panel,,7,411328,
7758330,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI053721-07,,NIAID:266586;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,VANCOUVER,CANADA,,,251949962,CA,BC,V6T 1Z3,UNIVERSITY OF BRITISH COLUMBIA,"KRONSTAD, JAMES W;",1932947;,5R01AI053721,08/01/2003,01/31/2014,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Antigenic Determinants; Assay; Autoregulation; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; CAPS; Capsules; Complex; Cryptococcus; Cryptococcus neoformans; DNA; DNA Binding; DNA Binding Interaction; Data; Defect; Deoxyribonucleic Acid; Disease; Disorder; Electrophoretic Mobility Shift Assay; Environment; Epitopes; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Foundations; Funding; Fungal Genes; Fungus Diseases; Gene Action Regulation; Gene Expression; Gene Expression Microarray Analysis; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genes, Fungal; Genetic Transcription; Glycans; Goals; Granulocyte/Pollen-Binding Protein; Growth; HIV; HTLV-III; Heme; Heme Iron; Heme b; Homeostasis; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immune system; Immunocompetent; Immunologic Deficiency Syndrome, Acquired; Incidence; Infection; Infection Control; Intermediary Metabolism; Iron; Knowledge; LAV-HTLV-III; Lead; Life; Link; Lymphadenopathy-Associated Virus; METBL; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Melanins; Metabolic Processes; Metabolism; Metals; Mobility Shift Assay; Modeling; Molecular; Molecular Interaction; Mycoses; Nutrient; Oxygenases; Pathogenesis; Pathogenicity Factors; Patients; Pb element; Phenotype; Photometry/Spectrum Analysis, Mass; Physiological Homeostasis; Play; Polysaccharides; Proliferating; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Binding; Proteins; Proteomics; Protoheme; Protoheme IX; Publishing; RNA Expression; Regulation; Regulatory Protein; Regulon; Research; Role; Siderophilin; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stealing; Stealings; Targetings, Gene; Testing; Theft; Time; Tissue Growth; Torula; Transcription; Transcription, Genetic; Transferrin; Virulence; Virulence Factors; Virus-HIV; Work; base; body system, allergic/immunologic; capsule (pharmacologic); combat; comparative; disease/disorder; experiment; experimental research; experimental study; ferroheme; functional genomics; fungal infection; fungus; fungus infection; gel shift assay; gene product; genetic promoter element; genetic regulatory protein; heavy metal Pb; heavy metal lead; interest; mutant; ontogeny; organ system, allergic/immunologic; pathogen; public health relevance; regulatory gene product; research study; response; social role; therapeutic target; transcription factor; uptake",Comparative and functional genomics of C. neoformans," Project Narrative. The relevance of this project comes from the pressing need to control fungal infections in humans with impaired immune systems. In particular, the 40 million or more people infected with HIV have a high chance of succumbing to fungal disease. The research will specifically examine the potential to control infections by targeting the ability of fungal pathogens to acquire the nutrient iron during infection.",53721,ZRG1,Special Emphasis Panel,,7,266586,
7761772,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI054139-07,,NIAID:539137;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"CONN, JAN E.;",1863752;,5R01AI054139,06/01/2002,01/31/2013,"Affect; Animal Welfare; Anopheles; Anopheles Genus; Area; Assay; Bibliography; Bioassay; Biologic Assays; Biological; Biological Assay; Biology; Boa; Brazil; Breeding; CYTOGEN; Case Study; Central America; Classification; Colombia; Complex; Country; Coupled; Critiques; Culicidae; Cytogenetic; Cytogenetics; Cytology; DNA, Mitochondrial; Data; Demography; Ecological impact; Ecology; Environment; Environmental Impact; Environmental Science; Epidemiology; Equipment; Ethics Committees, Research; Genes; Genetic; Genetic Structures; Genetic Vectors; Genetics, Population; Goals; Habitats; Hand; Health; History; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Laboratories; Lead; Malaria; Methods; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Mitochondria; Mitochondrial DNA; Molecular; Mosquitoes; Nuclear; Outcome; Paludism; Pattern; Pb element; Plasmodium Infections; Play; Population; Population Genetics; Population Studies / Demography; Principal Investigator; Programs (PT); Programs [Publication Type]; Racial Segregation; Recording of previous events; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Role; Sample Size; Source; South America; Systematics; Taxon; Testing; Transmission; Variant; Variation; Vertebrate Animals; Vertebrates; abstracting; anthropogenesis; anthropogenic; base; case report; comparative; design; designing; experiment; experimental research; experimental study; expiration; forest; frontier; heavy metal Pb; heavy metal lead; human subject; improved; member; mitochondrial; molecular marker; mtDNA; novel; programs; reproductive; research study; segregation; social role; tool; transfection vector; transmission process; vector; vector (nucleic acid cloning); vertebrata",Malaria Vector Biology in Brazil: Genetics and Ecology,,54139,VB,Vector Biology Study Section,,7,539137,
7762231,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI054359-07,,NIAID:327690;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"IWASAKI, AKIKO ;",7114700;,5R01AI054359,04/01/2003,01/31/2014,"APC; ATGN; Antigen-Presenting Cells; Antigens; Antiviral Agents; Antiviral Drugs; Antivirals; Applications Grants; Assay; Award; BACs (Chromosomes); Bacterial Artificial Chromosomes; Bioassay; Biologic Assays; Biological Assay; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Co-culture; Cocultivation; Coculture; Coculture Techniques; Corynebacterium Diphtheriae Toxin; DT-R; DTR; DTR Protein; DTS; Data; Dendritic Cells; Diphtheria Toxin; Diphtheria Toxin Sensitivity; Disease; Disorder; Epithelial Cells; Female; Foundations; Funding; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Generations; Genes; Genital; Genital System, Female, Vagina; Genital system; Goals; Grant Proposals; Grants, Applications; HB-EGF; HB-EGF precursor; HBEGF; HEGFL; HHV-2; HSV; HSV-2; HSV2; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hematopoietic; Herpes Genitalis; Herpes Simplex Virus; Herpes Simplex Virus 2; Herpes Simplex Virus Type 2; Herpes Simplex, Genital; Herpes labialis Virus; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus hominis; Herpesvirus progenitalis; High Prevalence; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human herpes simplex virus type 2; Immune; Immune response; Immunity; Immunologic Accessory Cells; Inducer Cells; Infection; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knockout Mice; Knowledge; LYT3; Life; Lymph node proper; Mammals, Mice; Measures; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Monocytes / Macrophages / APC; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Myxoid cyst; Nature; Neural Ganglion; Null Mouse; Peptides; Physiologic; Physiological; Prevalence; Process; Production; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Reporter; Reticuloendothelial System, Lymph Node; Role; STD; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Signal Transduction; Signal Transduction Systems; Signaling; Simplexvirus; Site; Surface; Symptoms; System; System, LOINC Axis 4; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TLR protein; TLR7; TLR7 protein, human; TLR7 receptor; Thymus-Dependent Lymphocytes; Toll-Like Receptor 7; Toll-like receptors; Transgenic Mice; Transmission; Vaccines; Vagina; Vaginal; Veiled Cells; Venereal Diseases; Venereal Disorders; Venereal Infections; Viral; Virus; Virus-Genital Herpes; Viruses, General; Work; accessory cell; base; biological signal transduction; cell type; design; designing; diphtheria toxin receptor; diptheria toxin receptor; disease prevention; disease/disorder; disorder prevention; genetic promoter element; genital herpes; genital infection; hTLR7; helper T cell; heparin-binding epidermal growth factor-like growth factor precursor; herpes genitalia; herpes simplex ii; herpesvirus; host response; human TLR7 protein; human alphaherpesvirus 2; human herpesvirus 1 group; immunogen; immunological intervention; immunoresponse; in vivo; insight; interventional strategy; keratinocyte; lymph gland; lymph nodes; mucosal site; pathogen; prevent; preventing; public health relevance; response; social role; thymus derived lymphocyte; toll-like receptor 7, human; transmission process; urogenital system (genital part); venereal herpes",Immune Induction to Genital Herpes Simplex Virus 2," 7. Project Narrative Herpes simplex virus-2 (HSV-2), a causative agent of genital herpes, is a highly prevalent (45 million in the USA alone) sexually transmitted infection. Once acquired, HSV-2 causes a life-long incurable debilitating disease for which no vaccines are currently available. This grant application proposes to examine the mechanism by which local dendritic cells in the female genital mucosa initiate immune responses against HSV-2 infection - the understanding obtained through the project will help to establish critical foundation with which to design immunological interventions and preventative measures against genital herpes and other deleterious sexually transmitted diseases.",54359,IHD,Immunity and Host Defense Study Section,,7,327690,
7760623,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI054520-07,,NIAID:429000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"WUCHERPFENNIG, KAI W;",1886366;,5R01AI054520,04/01/2003,01/31/2014,"ARAM; Ag Recognition Activation Motif; Aspartic Acid; Assay; Attention; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; CD3-Epsilon; CD3E Antigen Epsilon Polypeptide; CD3E Antigen, Epsilon Polypeptide (Tit3 Complex); CD3E Protein; CD3E antigen, epsilon polypeptide (TiT3 complex) protein, human; CD3E protein, human; CD3epsilon protein, human; CD94 Antigen; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Charge; Combining Site; Complex; Controlled Environment; Cyclicity; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; DAP12; Data; Dissociation; Environment; Environment, Controlled; Event; External Domain; Extracellular Domain; FRET; Fluorescence Resonance Energy Transfer; Funding; Goals; Hydrogen Bonding; Hydrogen Oxide; ITAM; Image; Imagery; Immune system; Immunoreceptor Tyr-Based Activation Motif; Immunoreceptor Tyrosine-Based Activation Motif; Intracellular Communication and Signaling; Investigation; KARAP; KLRD1 Protein; Killer Cell Lectin-Like Receptor Subfamily D, Member 1; Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2; Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein; Kp43 antigen; L-Aspartic Acid; L-Tyrosine; Label; Length; Life; Lipid Bilayers; Lipid Binding; Lipids; MHC Receptor; Major Histocompatibility Complex Receptor; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis, Site-Directed; NK Cell Receptor; NMR Spectroscopy; Natural Killer Cells Antigen CD94; OKT3 antigen; PLO-SL; PLOSL; Periodicity; Phosphatides; Phospholipids; Phosphorylation; Physiologic; Physiological; Plasma Membrane; Protein Phosphorylation; Proteins; Reactive Site; Receptor Protein; Receptor Signaling; Receptors, Antigen, T-Cell; Regulation; Rhythmicity; Role; Running; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Solutions; Spectroscopy, NMR; Staging; Structure; Surface; Surface Proteins; T-Cell Activation; T-Cell Antigen Receptor Complex, Epsilon Subunit of T3; T-Cell Receptor; T-Cell Surface Antigen T3/LEU-4 Epsilon Chain; T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cells; T-Lymphocyte; T3 Antigens; T3 Complex; T3 molecule; TM Domain; TYR; TYROBP; TYROBP gene; Targeted DNA Modification; Targeted Modification; Techniques; Thymus-Dependent Lymphocytes; Time; Transmembrane Domain; Transmembrane Region; Triad; Triad Acrylic Resin; Triad resin; Tyrosine; Tyrosine, L-isomer; VESCL; Variant; Variation; Vesicle; Visualization; Water; alpha helix; artificial environment; base; biological signal transduction; body system, allergic/immunologic; conformation; conformational state; design; designing; dimer; extracellular; fluorophore; gene product; human CD3E protein; imaging; lipid bilayer membrane; membrane structure; novel; nuclear magnetic resonance spectroscopy; organ system, allergic/immunologic; para-Tyrosine; plasmalemma; public health relevance; receptor; receptor function; social role; thymus derived lymphocyte",Structural Determinants of TCR Assembly and Signaling," Project Narrative The plasma membrane provides unique environments for protein-protein and protein- lipid interactions. The major goal of this project is to define how the membrane environment directs the assembly of the TCR-CD3 complex and the initiation of TCR signaling. These issues are likely to be relevant for many other receptors, and the studies described here may thus have a broad impact on our understanding of receptor function.",54520,CMIA,Cellular and Molecular Immunology - A Study Section,,7,429000,
7765578,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI055502-07,,NIAID:409209;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MEDZHITOV, RUSLAN ;",6114274;,5R01AI055502,07/01/2003,01/31/2014,"ATGN; Address; Antibody Formation; Antibody Production; Antibody Response; Antigens; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B blood cells; B cell differentiation factor; B cell stimulating factor 2; B-Cell Activation; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; B-Cells; B-Lymphocytes; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Maturation; Cell Signaling; Cells; Cells, CD4; Dendritic Cells; Development; Differentiation Factor, B-Cell; Disease; Disorder; Family; Funding; HPGF; Hepatocyte-Stimulating Factor; Host resistance; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; Immune response; Immunity; Infection; Inflammatory; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; Intracellular Communication and Signaling; Knock-out; Knockout; Ligands; Lymphocyte-Stimulating Hormone; MGI-2; Macrophage Cell Factor; Mammals, Mice; Mediating; Mice; Molecular; Murine; Mus; Myeloid Differentiation-Inducing Protein; Organism; Pathway interactions; Peripheral; Plasmacytoma Growth Factor; Play; Process; Public Health; Receptor Activation; Receptor Protein; Receptor Signaling; Refractory; Regulation; Regulatory T-Lymphocyte; Resistance to infection; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; T Helper Factor; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TLR protein; Thymus-Dependent Lymphocytes; Toll-like receptors; Veiled Cells; antibody biosynthesis; autoimmune disorder; biological signal transduction; cell type; disease/disorder; helper T cell; host response; immunogen; immunoglobulin biosynthesis; immunoresponse; in vivo; infection resistance; interferon beta 2; living system; lymphocyte activating factor; microbial; pathway; prevent; preventing; public health medicine (field); public health relevance; receptor; receptor function; response; self recognition (immune); sensor; social role; thymus derived lymphocyte",Toll Pathway & Control of Adaptive Immune Responses, Project Narrative Infectious and inflammatory diseases and autoimmunity carry a significant burden on public health. In this proposal we will investigate basic mechanisms that are involved in organism's protection from infections and mechanisms that prevent the development of autoimmune diseases.,55502,III,Innate Immunity and Inflammation Study Section,,7,409209,
7766984,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI056129-07,,NIAID:403425;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,OKLAHOMA CITY,UNITED STATES,,05,077333797,US,OK,731045005,OKLAHOMA MEDICAL RESEARCH FOUNDATION,"SUN, XIAO-HONG ;",7882822;,5R01AI056129,07/01/2003,01/31/2014,"ANK Domain; ANK Repeat; Address; Animals; Ankyrin Repeat; Ankyrin Repeat Domain; Antimorphic mutation; Autoimmune; Autoimmune Diseases; Autoimmune Process; B blood cells; B cell differentiation; B lymphocyte differentiation; B-Cell Development; B-Cells; B-Lymphocytes; Biochemical; Biological; Blood (Leukemia); Body Tissues; Bone Marrow; Boxing; Breeding; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Signaling; Closure by Ligation; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collection; Complex; Cytokine Signal Transduction; Cytokine Signaling; Data; Defect; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; E2A; E2A Immunoglobulin Enhancer Binding Factors E12/E47 Gene; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7.2-; Eukaryote; Eukaryotic Cell; Event; Extracellular Signal-Regulated Kinases; Family; Gene Expression; Gene Transcription; Genetic Transcription; ITF1; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; In Vitro; Individual; Intestinal; Intestines; Intracellular Communication and Signaling; Investigation; JAK kinase; Janus kinase; Knock-in; Knock-in Mouse; Lead; Learning; Leukemias, General; Leukemogenesis/Lymphomagenesis; Ligation; Lymphocyte; Lymphocytic; Lymphoid; Lymphomagenesis; Lymphopoiesis; MAP kinase; MAPK; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Murine; Mus; Mutant Strains Mice; Oncogenesis; Organ; Pb element; Phase; Process; Production; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Family; Protein Turnover; Proteins; RNA Expression; Reaction; Receptor Signaling; Regulation; Regulatory Pathway; Research; Resistance; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stromal Cells; Surface; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TCF3; TCF3 gene; Testing; Therapeutic Intervention; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissues; Transcription; Transcription, Genetic; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; autoimmune disorder; base; biological signal transduction; bowel; cell type; cytokine; disease/disorder; eukaryotida; gene product; heavy metal Pb; heavy metal lead; hypoimmunity; immune deficiency disorder; immunodeficiency; intervention therapy; leukemia; leukemogenesis; lymph cell; lymphocytopoiesis; malignancy; malignant breast neoplasm; mouse model; mouse mutant; mutant; neoplasm/cancer; notch; notch protein; notch receptors; overexpression; protein degradation; public health relevance; resistant; response; social role; thymus derived lymphocyte; transcription factor; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase",Notch-induced protein degradation in lymphopoiesis," Research Narrative  This project will yield groundbreaking information about an important family of proteins. These Notch receptors are essential for the normal development of many organs and tissues. However, improper regulation of Notch leads to cancer and there is much about Notch functions that remains a mystery. For example, our preliminary data suggest that Notch acts as a ringmaster, controlling the levels of many other proteins. While we suspect that it does this by regulating the stability of these proteins, and have promising leads, extensive study will be needed to reveal exactly how this works. There is good reason to believe the answers to these questions will lead to new treatments for several types of diseases. These include leukemias and cancers of the breast or intestine, autoimmune diseases and developmental defects.",56129,ZRG1,Special Emphasis Panel,,7,403425,
7766976,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI056305-07,,NIAID:388575;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"NORGARD, MICHAEL V;",1898335;,5R01AI056305,07/01/2003,01/31/2014,"3-D structure; 3-dimensional structure; 3D structure; ABC Transport Protein; ABC Transporter Protein; ABC Transporters; ATP-Binding Cassette Transporters; Active Follow-up; Agonist; Arts; Bacteria; Binding; Binding (Molecular Function); Biochemical; Biological; Biological Function; Biological Process; Biology; Complement; Complement Proteins; Complex; Crystallization; DNA Molecular Biology; Data; E coli; Escherichia coli; Funding; Genome; Globus Pallidus; Human; Human, General; Immune; Immune Targeting; In Vitro; Infection; Laboratories; Lactoferrin; Lactotransferrin; Lipoproteins; Man (Taxonomy); Man, Modern; Membrane; Membrane Biology; Membrane Proteins; Membrane-Associated Proteins; Methods and Techniques; Methods, Other; Molecular; Molecular Biology; Molecular Interaction; Nature; Order Spirochaetales; Organism; Pathogenesis; Pathogenicity Factors; Physiologic; Physiological; Physiology; Play; Polyamine Compound; Polyamines; Process; Proteins; Receptor Protein; Recombinants; Research; Role; STD; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Solubility; Spirochaetales; Spirochetes; Structure; Surface; Surface Proteins; Syphilis; System; System, LOINC Axis 4; T. pallidum; T.pallidum; Techniques; Treponema pallidum; United States; Venereal Diseases; Venereal Disorders; Venereal Infections; Virulence Factors; base; experiment; experimental research; experimental study; follow-up; gene product; genetic manipulation; great pox; living system; membrane structure; novel; pallidum; polypeptide; protein function; protein protein interaction; public health relevance; receptor; research study; social role; structural biology; three dimensional structure",Structure and Function of Treponema pallidum Lipoproteins," Project Narrative:  Syphilis remains an important sexually transmitted disease in the United States. Efforts to understand the complex nature of syphilis pathogenesis have been hindered by the inability to culture the etiological agent, Treponema pallidum, in the laboratory. This project seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo)proteins of the organism. These membrane proteins likely play strategic roles in sustaining T. pallidum during human infection. As such, our studies have the potential to elucidate the molecular bases of many new aspects of syphilis pathogenesis and, consequently, new potential avenues to thwart infection.",56305,ZRG1,Special Emphasis Panel,,7,388575,
7760566,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI056310-07,,NIAID:327041;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"PINTEL, DAVID J.;",1881959;,5R01AI056310,07/01/2003,01/31/2014,"5' Capped RNA; 5' mRNA Cap Structure; 5'-Adenylic acid, homopolymer; Adeno-Associated Viruses; Affect; Alternate Splicing; Alternative Splicing; Animal Viruses; Binding; Binding (Molecular Function); Biological Models; Capsid; Code; Coding System; Complex; DNA; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; Deoxyribonucleic Acid; Dependovirus; Disease; Disorder; Erythrovirus; Exons; Funding; Gene Expression; Gene Products, RNA; Gene Transcription; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic; Genetic Intervention; Genetic Transcription; Genome; Intervening Sequences; Intervention, Genetic; Introns; Knowledge; Length; Life Cycle; Life Cycle Stages; Mammals, Primates; Mediating; Model System; Modeling; Models, Biologic; Molecular; Molecular Biology, Gene Therapy; Molecular Genetic; Molecular Genetics; Molecular Interaction; Nuclear; Parvovirus; Picodnavirus; Play; Pol II; Poly A; Poly(rA); Polyadenylation; Pre-mRNA; Primates; Process; RNA; RNA Caps; RNA Expression; RNA Polyadenylation; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA, Viral; Relative; Relative (related person); Ribonucleic Acid; Role; Site; Splicing; Testing; Therapy, DNA; Transcription; Transcription, Genetic; Translation Initiation; Virus; Viruses, Animal; Viruses, General; adeno associated virus group; coat (nonenveloped virus); disease/disorder; gene therapy; genetic therapy; insight; life course; mRNA Precursor; parvovirus group; polyadenylate; premRNA; public health relevance; social role; viral RNA; virus RNA",Adeno-associated Virus RNA Splicing and Polyadenylation," PROJECT NARRATIVE (AI056310 - Pintel)  Parvoviruses are small (20nm) non-enveloped icosahedral viruses that infect and cause disease in many vertebrate hosts. They are also highly attractive vehicles for gene therapy applications. They are unique among all known animal viruses in that they contain single- stranded linear DNA genomes. They have a compact genetic organization featuring overlapping transcription units which utilize extensive alternative splicing, alternative polyadenylation, and alternative translation initiation. We have begun to characterize the mechanism of alternative polyadenylation of parvovirus RNA at the molecular level. We propose to expand this analysis in this proposal. The knowledge gained from our studies will advance our understanding of this important mechanism of gene expression in this important group of viruses.",56310,ZRG1,Special Emphasis Panel,,7,327041,
7755799,R01,AI,5,,02/10/2010,01/31/2011,PA-07-070,5R01AI057020-08,,NIAID:368504;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DAVIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"SHACKLETT, BARBARA L;",6304304;,5R01AI057020,07/11/2003,01/31/2013,"Analysis, Data; Animal Welfare; Antiretroviral Therapy, Highly Active; Area; Bibliography; Blood; Body Tissues; Bronchioalveolar Lavage; Bronchoalveolar Lavage; CD4 Lymphocyte Count; CD4+ Cell Counts; CD4+ Counts; Cells; Cerebrospinal Fluid; Characteristics; Collaborations; Compensation; Country; Data; Data Analyses; Disease Progression; Ecological impact; Enrollment; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Financial compensation; HAART; Highly Active Antiretroviral Therapy; Human Resources; IACUC; IRBs; Immune response; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Laboratories; Lavage, Bronchopulmonary; Letters; Lung Lavage; Lymphoid; Manpower; Mucosa; Mucosal Tissue; Mucous Membrane; Patients; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Blood; Site; Staging; T-Cells; T-Lymphocyte; T4 Lymphocyte Count; Thymus-Dependent Lymphocytes; Tissues; Vertebrate Animals; Vertebrates; Viral; Virus; Viruses, General; Visit; abstracting; anti-retroviral therapy, highly active; base; bronchopulmonary lavage therapy; cohort; enroll; expiration; gastrointestinal; host response; human subject; immunoresponse; personnel; programs; rectal; response; sharing data; spinal fluid; thymus derived lymphocyte; vertebrata",HIV-Specific T Cell Responses in Rectal Mucosa,,57020,AIP,AIDS Immunology and Pathogenesis Study Section,,8,368504,
7759188,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI057393-05,,NIAID:318272;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NOTRE DAME,UNITED STATES,CHEMISTRY,02,824910376,US,IN,46556,UNIVERSITY OF NOTRE DAME,"VAKULENKO, SERGEI ;",6480297;,5R01AI057393,02/15/2006,01/31/2011,"4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-; ATP[{..}]kanamycin 3'-O-phosphotransferase; Affect; Amikacin 3'-Phosphotransferase; Amino Acids; Aminobenzylpenicillin; Aminocyclitol Phosphotransferase; Aminoglycoside 3'-Phosphotransferase Type VIII; Aminoglycoside Agents; Aminoglycoside Antibiotics; Aminoglycoside Drugs; Aminoglycoside Phosphotransferase; Aminoglycoside resistance; Aminoglycoside resistant; Aminoglycosides; Ampicillin; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antibiotics, Aminoglycoside; Bacillus; Bacillus (bacterium); Bacteria; Cell Wall; Chemicals; Clinical; Development; EC 2.7; Enterococcus; Enzymatic Biochemistry; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzyme Kinetics; Enzymes; Enzymology; Evolution; Future; Garamicin; Garamycin; Genes; Genoptic; Genoptic S.O.P.; Gentamicins; Gram-Negative Bacteria; Hospital Infections; Hospital acquired infection; Infection; Kanamycin Kinase; Kanamycin-Neomycin Phosphate Transferase; Kinases; Kinetic; Kinetics; Knowledge; Lead; Mediating; Medical center; Miscellaneous Antibiotic; Neomycin Phosphotransferase; Nosocomial Infections; Pb element; Penicillin, Aminobenzyl; Phosphotransferases; Play; Public Health; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Role; Streptococcus enterococcus group; Structure; Therapeutic; Transphosphorylases; U-Gencin; United States; Vancomycin; aminoacid; anti-microbial; antibiotic resistant; antimicrobial; bactericidal; bactericide; cofactor; design; designing; directed evolution; effective therapy; enzyme substrate; heavy metal Pb; heavy metal lead; institutional infection; novel; public health medicine (field); resistance mechanism; resistance to aminoglycoside; resistant; resistant mechanism; resistant to aminoglycoside; social role",Aminoglycoside Resistance in Enterococci,,57393,ZRG1,Special Emphasis Panel,,5,318272,
7761238,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI057438-05,,NIAID:357172;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHARLOTTESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"BORISH, LARRY C;",1950536;,5R01AI057438,02/01/2006,01/31/2011,"2-(Acetyloxy)benzoic Acid; Acetylsalicylic Acid; Acidophilic Leukocyte; Address; Affinity; Agonist; Allergic; Aspergum; Aspirin; Assay; Asthma; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Band Shift Mobility Assay; Bandshift Mobility Assay; Binetrakin; Bioassay; Biologic Assays; Biological; Biological Assay; Blood Eosinophil; Bronchial Asthma; Bronchial Spasm; Bronchospasm; Chronic; Chronic Sinusitis; Cloning; Cys-LT; CysLT(2) receptor; CysLT2 receptor; Data; Disease; Disorder; Ecotrin; Electrophoretic Mobility Shift Assay; Empirin; Endothelium; Entericin; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Epithelium; Extren; Feedback; Fibrosis; Gene Transcription; Genes; Genetic Transcription; Gland; Grant; Hyperplasia; Hyperplastic; IL-13; IL-4; IL13; IL4; IL4 Protein; INFLM; IRS2; IRS2 protein, human; Individual; Inflammation; Inflammatory; Insulin Receptor Substrate 2; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Interleukins; Investigation; Investigators; Jobs; Knockout Mice; LTC4 synthase; Leukotrienes; Lung diseases; Lymphocyte Stimulatory Factor 1; MCGF-2; Marrow Eosinophil; Mast Cell Growth Factor-2; Measurin; Mediating; Mice, Knock-out; Mice, Knockout; Mobility Shift Assay; Molecular; Mucous body substance; Mucus; Nasal Cavity Polyp; Nasal Polyps; Null Mouse; Occupations; Pathway interactions; Procedures; Process; Production; Professional Postions; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Pulmonary Diseases; Pulmonary Disorder; RNA Expression; Reaction; Receptor Protein; Regulation; Reporting; Research Personnel; Researchers; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Role; Signaling Protein; Sinusitis; Site; Syndrome; T-Cell Growth Factor 2; Therapeutic; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; airway remodeling; airway smooth muscle; base; cysteinyl leukotriene receptor 2; cysteinyl-leukotriene; cytokine; desensitization; disease/disorder; effective therapy; eosinocyte; eosinophil; gel shift assay; human IRS2 protein; in vivo; leukotriene A4-glutathione S-leukotrienyltransferase; leukotriene C4 synthetase; leukotriene-C4 synthase; lung disorder; mucous; pathway; receptor; receptor expression; respiratory smooth muscle; social role; transcription factor; unspecified interleukin",Cysteinyl leukotrienes in chronic sinusitis and asthma,,57438,ZRG1,Special Emphasis Panel,,5,357172,
7760842,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI057450-05,,NIAID:309784;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN ANTONIO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"ZHONG, GUANGMING ;",6201479;,5R01AI057450,02/15/2006,01/31/2011,"Affinity; Animals; Antibodies; Apoptosis; Apoptosis Pathway; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bacterial Sexually Transmitted Diseases; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Vessels; C. pneumoniae; C. psittaci; C.pneumoniae; C.psittaci; CDC; Carcinoma of the Uterine Cervix; Categories; Cell Culture Techniques; Cell Death, Programmed; Cell Survival; Cell Viability; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cerebrum; Cervical Carcinoma; Cervix Uteri Carcinoma; Cervix carcinoma; Chlamydia; Chlamydia Infections; Chlamydia pneumoniae; Chlamydia psittaci; Chlamydial Infection; Chlamydophila pneumoniae; Chlamydophila psittaci; Clinical; Complement; Complement Proteins; Complex; Cytosol; Developed Countries; Developed Nations; Ensure; Esteroproteases; Eukaryote; Eukaryotic Cell; Expression Library; Feces; Figs; Figs - dietary; Future; Gastrointestinal Tract, Feces; Generalized Growth; Genes; Genitourinary; Genitourinary system; Genome; Genome Library; Genomic Library; Goals; Growth; Half-Life; Half-Lifes; Health; Host Defense; Human; Human, General; Immunity; Induction of Apoptosis; Industrialized Countries; Industrialized Nations; Infection; Investigators; Life; Life Cycle; Life Cycle Stages; Link; Location; Mammalian Cell; Man (Taxonomy); Man, Modern; Maps; Miyagawanella; Molecular Interaction; Organism; Pathology; Peptidases; Peptide Hydrolases; Peptides; Phage Display; Play; Pneumonia; Pneumonitis; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Pulmonary Inflammation; R. psittaci; R.psittaci; Random Peptide Libraries; Reagent; Research Personnel; Researchers; Resistance; Respiratory Infections; Respiratory Tract Infections; Rickettsia psittaci; Role; SEQ-AN; Scheme; Screening procedure; Sequence Analyses; Sequence Analysis; Sexually Transmitted Diseases, Bacterial; Stimulus; Structure; Study Section; Technology; Testing; Time; Tissue Growth; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Urogenital; Urogenital System; Vacuole; Venereal Diseases, Bacterial; Virus; Viruses, General; Work; aerosolized; atheromatosis; atherosclerotic vascular disease; base; bedsonia; biodefense; chlamydial disease; cofactor; design; designing; eukaryotida; experience; gene product; genome-wide; improved; inhibitor; inhibitor/antagonist; life course; living system; microbial; ontogeny; pathogen; prevent; preventing; programs; resistant; screening; screenings; social role; stool; success; trafficking; urogenital system (urinary part); vascular",Chlamydial Manipulation of Host Apoptosis,,57450,HIBP,Host Interactions with Bacterial Pathogens Study Section,,5,309784,
7758850,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI057481-05,,NIAID:321454;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCKVILLE,UNITED STATES,,08,144676566,US,MD,20852,HENRY M. JACKSON FDN FOR THE ADV MIL/MED,"SCHAEFER, BRIAN ;",7604564;,5R01AI057481,02/01/2006,01/31/2011,"ATGN; Ally; Antigen Receptors; Antigens; Antigens, LD; Basic Research; Basic Science; Biochemical; Cell Communication and Signaling; Cell Signaling; Cell division; Cells; Closure by Ligation; Collection; Complex; Coupled; Data; Development; Drugs; Evaluation; Event; Family; Foundations; Gene Expression; Goals; Imaging Procedures; Imaging Techniques; Immunoglobulin Enhancer-Binding Protein; Individual; Intracellular Communication and Signaling; Lead; Life; Ligation; Lymphocyte antigen; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Medication; Mice; Modification; Molecular; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Outcome; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Play; Process; Protein Cleavage; Protein Phosphorylation; Proteins; Proteolysis; Receptor Activation; Receptors, Antigen; Receptors, Antigen, T-Cell; Regulation; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Protein; T Cell Receptor Signaling Pathway; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; Technics, Imaging; Testing; Thymus-Dependent Lymphocytes; Transcription Factor NF-kB; Transducers; Work; biological signal transduction; drug/agent; experiment; experimental research; experimental study; functional outcomes; gene product; heavy metal Pb; heavy metal lead; immunogen; insight; kappa B Enhancer Binding Protein; lymphocyte differentiation antigen; novel; nuclear factor kappa beta; pathway; protein complex; protein distribution; protein protein interaction; research study; response; social role; thymus derived lymphocyte; transcription factor",Protein redistribution in TCR-directed NF-kB activation,,57481,CMIA,Cellular and Molecular Immunology - A Study Section,,5,321454,
7755035,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI058190-05,,NIAID:361201;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"PRABHAKAR, BELLUR S;",1888848;,5R01AI058190,02/01/2006,01/31/2011,"ATGN; Adoptive Transfer; Affect; Antigen Presentation Pathway; Antigen Processing and Presentation; Antigens; Apoptosis; Apoptosis Pathway; Apoptotic; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Responses; Autoimmune thyroiditis; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Chronic Lymphocytic Thyroiditis; Clinical; Colony-Stimulating Factors; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Dendritic Cells; Dendritic cell activation; Development; Disease; Disorder; Edodekin Alfa; Exposure to; FLT1; FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Flt-1; GM-CSF; GMCSF; Gamma interferon; Generations; Granulocyte-Macrophage Colony-Stimulating Factor; Hashimoto Disease; Hashimoto's Disease; Hashimoto's Struma; Hashimoto's Thyroiditis; Hashimoto's syndrome; Hashimotos Disease; Head and Neck, Thyroid; Histamine-Producing Cell-Stimulating Factor; Hypothyroidism; IFN-Gamma; IFN-g; IFNG; IL-10; IL-10 receptor; IL-12; IL-4; IL10; IL10A; IL12; IL4; IL4 Protein; Immune response; In Vitro; Infiltration; Inflammatory; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 10 Precursor; Interleukin-10; Interleukin-12; Interleukin-4; Interleukin-4 Precursor; Intracellular Communication and Signaling; Knockout Mice; Ligands; Literature; Lymphocyte; Lymphocyte Stimulatory Factor 1; Lymphocytic; MCGF-2; MGI-1 Protein; Mammals, Mice; Mast Cell Growth Factor-2; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molgramostin; Murine; Mus; Myeloid Cell-Growth Inducer; NKSF; Natural Killer Cell Stimulatory Factor; Null Mouse; PTK Receptors; Pathogenesis; Phenotype; Production; Proto-Oncogene Protein flt; RTK; Receptor Protein-Tyrosine Kinases; Receptor Tyrosine Kinase,Class V; Regulatory T-Lymphocyte; Relative; Relative (related person); Role; SCID; SCID Mice; Severe Combined Immunodeficient Mice; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stimulus; Subcellular Process; T-Cell Activation; T-Cell Growth Factor 2; T-Cell Proliferation; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TC-GM-CSF; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Thyroglobulin; Thyroglobulin antibody; Thyroid; Thyroid Gland; Thyroiditis; Thyroiditis, Lymphocytic; Thyroiditis, Lymphomatous; Transmembrane Receptor Protein Tyrosine Kinase; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Tumor-Cell Human GM Colony-Stimulating Factor; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Protein Kinase FRT; Tyrosine Protein Kinase Receptor FLT; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; VEGFR-1; VEGFR1; Vascular Endothelial Growth Factor Receptor-1; Veiled Cells; anti-thyroglobulin; anti-thyroglobulin antibody; antithyroglobulin; autoimmune disorder; base; biological signal transduction; cytokine; disease/disorder; fms-Like Tyrosine Kinase; granulocyte macrophage colony stimulating factor; helper T cell; host response; human TNF protein; immunogen; immunoresponse; in vivo; insight; interleukin-10 receptor; lFN-Gamma; lymph cell; neutralizing antibody; prevent; preventing; protective effect; response; severe combined immune deficiency; social role; thymus derived lymphocyte; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",Therapeutic treatment of EAT by inducing dendritic cell,,58190,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,361201,
7754675,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI059340-05,,NIAID:281964;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"BRESNAHAN, WADE A;",6142435;,5R01AI059340,02/01/2006,01/31/2011,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Affect; Biochemical; Biological; CMV; Cell Cycle; Cell Division Cycle; Cells; Clinical; Cytomegalic Inclusion Disease; Cytomegalovirus; Cytomegalovirus Infections; DNA Binding; DNA Binding Interaction; Development; Disease; Disorder; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, Immediate-Early; Genes, Viral; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; HCMV; Herpesviridae; Herpesviruses; Immediate-Early Genes; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Inclusion Disease; Individual; Infection; Lead; Life Cycle; Life Cycle Stages; Molecular; Mutation; Pathogenesis; Patients; Pb element; Physiologic; Physiological; Play; Population; Process; Programs (PT); Programs [Publication Type]; Proteins; RNA Expression; Research; Role; Salivary Gland Virus Disease; Salivary Gland Viruses; Testing; Therapeutic; Transcription; Transcription, Genetic; Transplant Recipients; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Genome; Viral Proteins; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Viruses, General; combat; cytomegalovirus group; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; herpes virus; human cytomegalovirus; immunosuppressed patient; life course; mutant; neonate; new approaches; novel; novel approaches; novel strategies; novel strategy; programs; recombinant virus; research study; social role; transplant patient; viral infection; virus host interaction; virus infection; virus multiplication; virus protein",Functional Analysis of Cytomegalovirus Tegument Proteins,,59340,VIRA,Virology - A Study Section,,5,281964,
7758848,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI059636-05,,NIAID:395059;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,622146454,US,NY,100214872,HOSPITAL FOR SPECIAL SURGERY,"IVASHKIV, LIONEL B;",1884538;,5R01AI059636,02/15/2006,01/31/2011,"Alferon; Alpha-Beta-Omega Interferon Receptor-1; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigen-Antibody Complex; Antiinflammatories; Antiinflammatory Agents; Antiviral Protein Alpha Type; Area; Attenuated; Autoantibodies; Autoimmune Status; Autoimmunity; Automobile Driving; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biology; Blood Cells; CMK; CRG-2; CSIF; CSIF-10; CXCL10; CXCL10 gene; CXCL9; CXCL9 gene; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Closure by Ligation; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytokines, Chemotactic; Dendritic Cells; Development; Differentiation Factor, B-Cell; Disease; Disorder; Drivings, Automobile; Exposure to; G-interferon; Genes; Ginterferon; HPGF; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; HuIFN-Alpha-Rec; Human; Human, General; Humig; Hybridoma Growth Factor; IFI10; IFN; IFN Alpha; IFN-Alpha-REC; IFN-beta 2; IFNB2; IFNBR; IFNa; IFRC; IL-10; IL-6; IL10; IL10A; IL6 Protein; INFLM; INP10; IP-10; Immune Complex; Immunosuppressants; Immunosuppressive Agents; Inbred NZB Mice; Inflammation; Inflammatory; Intercrines; Interferon Alfa-n3; Interferon Alpha-Beta Receptor Alpha Chain; Interferon Type I; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Interferons; Interleukin 10 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin-10; Interleukin-6; Intracellular Communication and Signaling; Kidney; Ligation; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lupus Glomerulonephritis; Lupus Nephritis; MGI-2; MIG; MIG Gene; MOB-1; Macrophage Activation; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Inbred NZB; Modeling; Molecular; Mouse, NZB; Murine; Mus; Myeloid Differentiation-Inducing Protein; Pathogenesis; Patients; Peripheral Blood Cell; Phase; Physiologic; Physiological; Plasmacytoma Growth Factor; Production; Regulation; Role; SCYB10; SCYB9; SIS cytokines; SLE; SLE - Lupus Erythematosus, Systemic; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Subcellular Process; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Testing; Urinary System, Kidney; Veiled Cells; autoimmune antibody; biological signal transduction; chemoattractant cytokine; chemokine; crg-10; cytokine; disease/disorder; disseminated lupus erythematosus; driving; experiment; experimental research; experimental study; extracellular; gIP-10; ifnar1 gene product; immunosuppressive; in vivo; insight; interest; interferon beta 2; macrophage; novel therapeutic intervention; protective effect; renal; research study; response; self reactive antibody; self recognition (immune); social role; systemic lupus erythematosis; therapeutic target; transcription factor; type I IFN receptor; type I interferon receptor",Interferon Regulation in Systemic Lupus,,59636,ZRG1,Special Emphasis Panel,,5,395059,
7755015,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI059638-04,,NIAID:358341;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RICHMOND,UNITED STATES,BIOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"RYAN, JOHN J;",2201128;,5R01AI059638,02/01/2007,01/31/2012,"Allergy; Anaphylactic Reaction; Anaphylaxis; Apoptosis; Apoptosis Pathway; Area; Arthritis; Asthma; Autocrine Systems; Autoimmune Diseases; Autoregulation; Basophilic Histiocyte; Basophils, Tissue; Bronchial Asthma; CD 23 Antigens; CD23 Antigens; CD25; CSIF; CSIF-10; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Cycle Arrest; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Chronic; Clinical; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Data; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Heart Diseases; Homeostasis; Human; Human, General; Hyperplasia; Hyperplastic; Hypersensitivity; IL-10; IL10; IL10A; IL2R; IL2RA; IL2RA gene; INFLM; IgE; IgE Receptors; Immunoglobulin E; Immunoglobulin E Receptor; In Vitro; Infection; Inflammation; Inflammatory; Injection of therapeutic agent; Injections; Interleukin 10 Precursor; Interleukin-10; Intracellular Communication and Signaling; Investigators; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Mast-Cell Disease; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Modeling; Multiple Sclerosis; Murine; Mus; Nippostrongylus; Pathway interactions; Physiological Homeostasis; Process; Production; Receptors, IgE; Recruitment Activity; Regulatory T-Lymphocyte; Research Personnel; Researchers; Role; Sclerosis, Disseminated; Shock, Anaphylactic; Signal Transduction; Signal Transduction Systems; Signaling; Source; Subcellular Process; Surface; System; System, LOINC Axis 4; T-Lymphocyte, Regulatory; TCGFR; Testing; arthritic; autocrine; autoimmune arthritis; autoimmune disorder; biological signal transduction; disease/disorder; epsilon Fc Receptors; heart disorder; in vivo; in vivo Model; insular sclerosis; mast cell; mast cell hyperplasia; mastocyte; mastocytosis; paracrine; pathway; prevent; preventing; receptor expression; recruit; response; social role; tool",IL-10 Regulates Mast Cell Function and Survival,,59638,III,Innate Immunity and Inflammation Study Section,,4,358341,
7759644,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI059663-05,,NIAID:391357;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"FELDMESSER, MARTA L.;",1888266;,5R01AI059663,02/01/2006,01/31/2011,"ATGN; Alveolar Macrophages; Antifungal Agents; Antifungal Drug; Antigens; Aspergillosis; Aspergillus; Aspergillus fumigatus; Asthma; Autoimmune Diseases; Binding; Binding (Molecular Function); Body Tissues; Bronchial Asthma; Cancers; Clinical, Transplantation, Organ; Development; Diagnosis; Diagnostic; Disease; Disorder; Fungicides, Therapeutic; Germination; Goals; Grafting Procedure; ITX; Immune Function, Cellular; Immune response; Immunity; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologically Directed Therapy; Immunosuppressed Host; Immunotherapeutic agent; Immunotherapy; In Vitro; Incidence; Infection; Kinetic; Kinetics; Lung; Macrophages, Alveolar; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mice; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Mortality; Mortality Vital Statistics; Murine; Mus; Neutropenia; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Patients; Phase Transition; Protein Binding; Proteins; Pulmonary Macrophages; Refractory; Reproduction spores; Resistance; Respiratory System, Lung; Spores; Therapeutic; Tissues; Transplantation Surgery; anti-fungal; antifungals; autoimmune disorder; disease/disorder; drug development; gene product; host response; immune function; immune therapy; immunogen; immunologic preparation; immunoresponse; immunosuppressed patient; immunotherapeutics; in vivo; malignancy; microbial; neoplasm/cancer; novel; organ allograft; organ graft; organ xenograft; pathogen; protective efficacy; protein expression; pulmonary; resistant; success",Monoclonal antibodies to inhibit Aspergillus germination,,59663,PTHE,Pathogenic Eukaryotes Study Section,,5,391357,
7746443,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI059714-07,,NIAID:423002;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"NEMAZEE, DAVID ;",1864731;,5R01AI059714,02/01/2004,01/31/2014,"ATGN; Active Follow-up; Address; Affect; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antibody Specificity; Antigens; Autoantibodies; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B blood cells; B cell receptor; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Binding Sites; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Candidate Disease Gene; Candidate Gene; Cell Lineage; Cell membrane; Cell surface; Cells; Chimera Protein; Chimeric Proteins; Class Switching; Combining Site; Common Rat Strains; Constant Region; Constant Region, Ig; Custom; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Defect; Development; Engineering; Engineerings; Fc domain; Funding; Fusion Protein; Gamma Globulin, 19S; Gamma Globulin, 7S; Generations; Genes; Genes, Class I; Genes, MHC Class I; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Germinal Center; Goals; Grant; Hybridomas; IgD; IgE; IgG; IgG1; IgM; Immune Globulins; Immune Tolerance; Immune system; Immunoglobulin Class Switching; Immunoglobulin Constant Region; Immunoglobulin D; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunoglobulins / Antibodies; Immunologic Tolerance; Inbred MRL lpr Mice; Insertional Mutagenesis; Isotype Switching; Knockout Mice; Lead; Link; Location; Lupus Erythematosus; Lymphocyte; Lymphocytic; MHC Class I; MHC Class I Genes; Mammals, Mice; Mammals, Rats; Membrane Proteins; Membrane-Associated Proteins; Memory; Memory B Cell; Memory B-Lymphocyte; Mice; Mice, Inbred MRL lpr; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Microbe; Moab, Clinical Treatment; Modeling; Molecular Interaction; Monoclonal Antibodies; Mouse Strains; Mouse, MRL lpr; Murine; Mus; Mutagenesis, Insertional; Mutant Strains Mice; Mutation; Null Mouse; Pb element; Phenotype; Plasma Membrane; Process; Rat; Rattus; Reactive Site; Receptor Gene; Receptors, Antigen, B-Cell; Regulation; Reticuloendothelial System, Bone Marrow; Series; Somatic Cell; Specificity; Staging; Structure; Structure of germinal center of lymph node; Superantigens; Surface Proteins; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; System; System, LOINC Axis 4; Tail; Technology; Testing; Transgenes; Transgenic Mice; Transgenic Organisms; antibody biosynthesis; autoimmune antibody; autoimmune disorder; autoreactive B cell; base; body system, allergic/immunologic; design; designing; follow-up; genome mutation; heavy metal Pb; heavy metal lead; immune system tolerance; immune unresponsiveness; immunogen; immunoglobulin biosynthesis; immunological paralysis; improved; in vivo; knockout gene; lymph cell; mouse mutant; mutant; novel; organ system, allergic/immunologic; plasmalemma; public health relevance; reconstitute; reconstitution; response; self reactive antibody; self recognition (immune); transgenic",Immune Tolerance in Non-clonal Immune Systems," Project narrative During the antibody response, antibody binding to microbes improves, owing to an intentional mutation process in B cells, the precursors of antibody forming cells. Because this natural mutation process can lead to self reactivity, it is important to understand how self reactive antibody formation is avoided. It is suspected that the regulation of B cells may go awry in autoimmune diseases such as lupus erythematosus. The goal of this project is to determine how immune tolerance normally suppresses the generation of self reactive antibodies and to identify genes involved in the process.",59714,TTT,"Transplantation, Tolerance, and Tumor Immunology",,7,423002,
7755394,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI059742-05,,NIAID:272298;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MANHASSET,UNITED STATES,,05,110565913,US,NY,11030,FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH,"SHERRY, BARBARA A;",1886104;,5R01AI059742,02/01/2006,01/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Aspergillus fumigatus; Back; Bacterial Infections; Binding; Binding (Molecular Function); Biochemical; Blood leukocyte; C-C CKR-1 Gene; C-C CKR-5 Gene; C-C Chemokine Receptor Type 1 Gene; C-C Chemokine Receptor Type 5 Gene; CC-CKR-1 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCR-1 Gene; CCR-5 Gene; CCR1; CCR1 gene; CCR5; CCR5 gene; CD195 Antigen Gene; CHEMR13 Gene; CKR-1 Gene; CKR-5 Gene; CKR5 Gene; CMKBR1 Gene; CMKBR5 Gene; CMKR1 Gene; Cell Communication and Signaling; Cell Signaling; Cell surface; Cells; Cessation of life; Chemokine (C-C) Receptor 5 Gene; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chronic; Clinical; Closure by Ligation; Complication; Critical Illness; Critically Ill; Cytokines, Chemotactic; Data; Death; Defect; Depressed mood; Development; Dialysis patients; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Endotoxemia; Extracellular Signal-Regulated Kinase Gene; Family; Functional disorder; GTP Phosphohydrolases; GTPases; Goals; Gram-Negative Bacteria; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HIV-1 Fusion Co-Receptor Gene; HM145 Gene; HOSP; Homologous Chemotactic Cytokines; Hospitals; Host Defense; Immune response; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Individual; Infection; Inflammatory Response; Injury; Intercrines; Intracellular Communication and Signaling; Investigators; Isoforms; Kinetic; Kinetics; Knowledge; LD78 Receptor Gene; Left; Leukocytes; Ligation; Link; Lipid Rafts, Cell Membrane; Lung; MAP Kinase Gene; MAPK; MIP-1Alpha-R Gene; MIP1aR Gene; Macrophage Inflammatory Protein-1 Alpha Receptor Gene; Mammals, Mice; Marrow leukocyte; Mediating; Membrane; Membrane Microdomains; Methods and Techniques; Methods, Other; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; Nosocomial pneumonia; Outcome; Pathway interactions; Patients; Phase; Physiopathology; Pilot Projects; Play; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Process; Protein Isoforms; Protein-Tyrosine Kinases, src; Proteins; Puncture procedure; Punctures; Quelling; RANTES Receptor Gene; RANTES-R Gene; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Recycling; Regulation; Reporting; Research; Research Personnel; Researchers; Resolution; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Risk; Role; SIS cytokines; SUBGP; Secondary to; Sepsis; Sepsis Syndrome; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Sphingolipids; Subgroup; Surface; Susceptibility; System; System, LOINC Axis 4; Systemic Inflammatory Response Syndrome; Techniques; Testing; Therapeutic Intervention; Vav guanine-nucleotide exchange factor; White Blood Cells; White Cell; Work; bacterial disease; base; biological signal transduction; bloodstream infection; chemoattractant cytokine; chemokine; chemokine receptor; cytokine; depressed; gene product; guanosinetriphosphatase; healthy volunteer; high risk; hospital acquired pneumonia; hospital associated pneumonia; host response; human disease; immunoresponse; immunosuppressed patient; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; intervention design; intervention therapy; knockout gene; lipid raft; macrophage; member; membrane structure; migration; model organism; new therapeutics; next generation therapeutics; novel therapeutics; pathogen; pathophysiology; pathway; pilot study; prevent; preventing; pulmonary; receptor; receptor downregulation; receptor expression; receptor internalization; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; sadness; secondary infection; septic; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; therapy design; trafficking; treatment design; white blood cell; white blood corpuscle",Regulation of Chemokine Receptor Expression in Sepsis,,59742,ZRG1,Special Emphasis Panel,,5,272298,
7754458,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI060025-07,,NIAID:329440;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"SILVERMAN, NEAL ;",1956780;,5R01AI060025,02/15/2004,07/31/2011,"AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Activator Protein-1; Atrophic Arthritis; Binding; Binding (Molecular Function); Biological Models; Cell Communication and Signaling; Cell Mediated Immunology; Cell Signaling; Cell-Death Protease; Cell-Mediated Immunity; Cells; Cellular Immunity; Complex; Cytokine Gene; Disease; Disorder; Drosophila; Drosophila genus; EC 2.7; Enhancer-Binding Protein AP1; Esteroproteases; Expression Profiling; Expression Signature; Flies; Fruit Fly, Drosophila; Gene Expression; GeneHomolog; Genes; Genetic; Goals; Gram-Negative Bacteria; Homolog; Homologous Gene; Homologue; Host Defense; Human; Human, General; ICE-like protease; Immune; Immune Function, Cellular; Immune response; Immune system; Immunity; Immunity, Cellular; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; In Vitro; Infection; Inflammatory; Inflammatory Arthritis; Insecta; Insects; Intracellular Communication and Signaling; Invaded; Invertebrates, Insects; Investigators; Isoforms; JN kinase kinase; JNK; JNK kinase; JNK-activating protein kinase; JNK1; JNK1A2; JNK21B1/2; JNKK; Jun amino-terminal kinase kinase; Kinases; Lead; Ligands; Lipid A; Lupus; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Maps; Mediating; Methods; Microorganisms, General; Model System; Models, Biologic; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Murein; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Oligosaccharides; Organism; PRKM8; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Peptidoglycan; Phosphorylation; Phosphotransferases; Play; Programs (PT); Programs [Publication Type]; Proteases; Protein Isoforms; Protein Phosphorylation; Proteinases; Proteolytic Enzymes; Receptor Protein; Receptor Signaling; Research; Research Personnel; Researchers; Rheumatoid Arthritis; Role; SAPK1; Sepsis; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Stress; Transcription Factor AP-1; Transcription Factor NF-kB; Transphosphorylases; anti-microbial; antimicrobial; antimicrobial peptide; biological signal transduction; bloodstream infection; body system, allergic/immunologic; caspase; combat; cross-link; crosslink; cystein protease; cystein proteinase; cysteine endopeptidase; design; designing; disease/disorder; effective therapy; experiment; experimental research; experimental study; fly; fruit fly; heavy metal Pb; heavy metal lead; host response; human disease; immune function; immunoresponse; in vivo; kappa B Enhancer Binding Protein; living system; microbial; microorganism; molecuar profile; molecular signature; novel; nuclear factor kappa beta; organ system, allergic/immunologic; overexpression; pathogen; pathway; programs; receptor; research study; social role",Activation of Insect Immunity by Gram-negative Bactria,,60025,ZRG1,Special Emphasis Panel,,7,329440,
7758845,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI060469-05,,NIAID:312330;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATHENS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"HONDALUS, MARY ;",7817430;,5R01AI060469,02/01/2006,01/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Actinobacteria; Actinobacteria class; Actinomyces; Actinomycetes; Address; Affect; Aspiration, Respiratory; Assay; Attenuated; Bacteria; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biology; Breathing; Cancers; Cell Communication and Signaling; Cell Signaling; Cellular biology; Clinical; Combining Site; Complex; Corynebacterium equi; Data; Defect; Development; Disease; Disorder; Epidemic; Event; Gene Family; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic analyses; Genetics-Mutagenesis; Goals; Gram-Positive Bacteria, High G+C; Granulomatous; Growth; HIV; HTLV-III; High temperature of physical object; Homolog; Homologous Gene; Homologue; Host Defense; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; INFLM; Immunity; In Vitro; Individual; Infection; Inflammation; Inhalation; Inhaling; Inspiration, Respiratory; Intracellular Communication and Signaling; Investigation; Investigators; Ions; Killings; Knowledge; LAV-HTLV-III; Life; Light; Lipoproteins; Location; Lymphadenopathy-Associated Virus; Lysosomes; Macrophage Cell Biology; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Methods; Mice; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Mechanisms of Action; Monitor; Mortality; Mortality Vital Statistics; Murine; Mus; Mutagenesis; Nature; Obstruction; Oxidative Stress; Pathogenesis; Pathway interactions; Persons; Phagocytosis; Phagosomes; Phenotype; Photoradiation; Physiology; Plasmids; Pneumonia; Pneumonitis; Position; Positioning Attribute; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pulmonary Inflammation; R Factors; R Plasmids; Reactive Site; Recombinants; Regulation; Regulatory Pathway; Regulon; Reporter; Research; Research Personnel; Research Resources; Researchers; Resistance Factors; Resources; Rhodococcus equi; Role; Signal Transduction; Signal Transduction Systems; Signaling; Soil; Stimulus; Sum; Surface; System; System, LOINC Axis 4; Temperature; Testing; Time; Tissue Growth; Tuberculosis; Virulence; Virus-HIV; Work; attenuation; base; biological signal transduction; cell biology; chemotherapy; disease/disorder; disseminated TB; disseminated tuberculosis; expectation; gene product; genetic analysis; genetic manipulation; high temperature; in vivo; innovate; innovation; innovative; insight; inspiration; intracellular parasitism; macrophage; malignancy; member; mouse model; mutant; neoplasm/cancer; novel; ontogeny; pathogen; pathway; programs; response; social role; tool; trafficking; tuberculous spondyloarthropathy",Virulence of the Opportunistic Pathogen Rhodococcis Equi,,60469,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,5,312330,
7900573,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI062735-07,,NIAID:333813;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GALVESTON,UNITED STATES,PATHOLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"WIKEL, STEPHEN K;",2437330;,5R01AI062735,02/01/2005,01/31/2011,"ATGN; Adoptive Transfer; Antigens; B. burgdorferi; B.burgdorferi; BALB/c; Black-legged Tick; Borrelia Infections; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cells, CD4; Genes; Genetic; Head and Neck, Salivary Glands; Hemagglutinin; Human; Human, General; I. scapularis; Immune; Immune response; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inbred BALB C Mice; Infectious Agent; Influenza HA; Influenza Hemagglutinin; Ixodes scapularis; Ixodid ticks; Ixodida; Lyme Borreliosis; Lyme Disease; Lyme Disease Spirochete; MHC Receptor; Major Histocompatibility Complex Receptor; Man (Taxonomy); Man, Modern; Mice, Inbred BALB C; Modeling; Mouse, BALB C; Nymph; Receptors, Antigen, T-Cell; Recombinants; Reporting; Salivary Gland Proteins; Salivary Glands; Salivary Proteins; Sensitization, Immunologic; Sensitization, Immunological; System; System, LOINC Axis 4; T-Cell Receptor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Tick Infestations; Tick-Borne Diseases; Ticks; Transgenic Organisms; Transmission; United States; base; borreliosis; cytokine; helper T cell; host response; immunogen; immunoresponse; in vivo; infectious organism; lyme spirochete; pathogen; reconstitute; reconstitution; response; thymus derived lymphocyte; transgenic; transmission process",Tick polarized T-cell responses and Borrelia infection,,62735,ZRG1,Special Emphasis Panel,,7,333813,
7760843,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI062827-05,,NIAID:399608;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,GENETICS,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"STARNBACH, MICHAEL N;",1864810;,5R01AI062827,02/01/2006,01/31/2011,"Acute; Affect; Alleles; Allelomorphs; Animals; Bacterial Sexually Transmitted Diseases; Blindness; Bone Marrow; Candidate Disease Gene; Candidate Gene; Cells; Chlamydia; Chlamydia Infections; Chlamydia trachomatis; Chlamydial Infection; Chronic; Communicable Diseases; Complex; DISSEC; Development; Diagnostic; Disease; Disorder; Dissection; Elements; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetic analyses; Host resistance; Human; Human, General; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Knock-out; Knockout; Knowledge; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mice; Miyagawanella; Modeling; Molecular; Mouse Strains; Murine; Mus; Outcome; Phenotype; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Process; Programs (PT); Programs [Publication Type]; QTL; Quantitative Trait Loci; Research Personnel; Researchers; Resistance; Resistance to infection; Reticuloendothelial System, Bone Marrow; Rickettsia trachomae; Role; STD; Severities; Severity of illness; Sexually Transmitted Diseases; Sexually Transmitted Diseases, Bacterial; Sexually Transmitted Disorder; Sexually Transmitted Infection; Source; Susceptibility; Symptoms; Systemic infection; Testing; Transgenic Organisms; Transplantation; Vacuole; Variant; Variation; Variation (Genetics); Venereal Diseases; Venereal Diseases, Bacterial; Venereal Disorders; Venereal Infections; allelic variant; base; bedsonia; chlamydial disease; congenic; data modeling; design; designing; disease severity; disease/disorder; experiment; experimental research; experimental study; gene function; genetic analysis; genome sequencing; genome, mouse; human disease; infection resistance; mouse genome; mouse model; pathogen; polymorphism; positional cloning; programs; research study; resistant; reverse genetics; social role; transgenic; transplant",Genetics of Host Resistance to Chlamydia trachomatis,,62827,GHD,Genetics of Health and Disease Study Section,,5,399608,
7760639,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI063365-05,,NIAID:337499;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,KNOXVILLE,UNITED STATES,PATHOLOGY,02,003387891,US,TN,379961529,UNIVERSITY OF TENNESSEE KNOXVILLE,"ROUSE, BARRY T.;",1885308;,5R01AI063365,02/01/2006,01/31/2011,"ATGN; Affect; Antigens; Antiviral Agents; Antiviral Drugs; Antivirals; Biological Models; Body Tissues; CD25; Cells; Cold Sore; Drug Formulations; Encephalitis; Event; Fever Blister; Formulation; Formulations, Drug; Goals; Grant; HSV; Herpes Labialis; Herpes Simplex Virus; Herpes Simplex, Labial; Herpes labialis Virus; Herpesvirus hominis; Human; Human, General; IL2R; IL2RA; IL2RA gene; Immune; Immune response; Immunity; Infection; Infectious Agent; Inflammation, Brain; Influenza Virus; Keratitis; L. monocytogenes; Lesion; Life; Listeria monocytogenes; Man (Taxonomy); Man, Modern; Measures; Memory; Model System; Models, Biologic; Outcome; Pain; Painful; Persons; Phase; Predisposition; Prevention; Public Health; Recurrence; Recurrent; Regulatory T-Lymphocyte; Research; Research Design; Simplexvirus; Study Type; Superinfection; Superinvasion, Microbial; Susceptibility; System; System, LOINC Axis 4; T-Lymphocyte, Regulatory; TCGFR; Testing; Tissues; Vaccine Design; Vaccines; Viral Diseases; Virus; Virus Diseases; Viruses, General; base; cell type; herpes febrilis; herpesvirus; host response; human herpesvirus 1 group; immunogen; immunopathology; immunoresponse; in vivo; infectious organism; influenzavirus; influenzavirus (unspecified); mouse model; pathogen; public health medicine (field); response; study design; viral infection; virus infection",T regulatory Cells in HSV Immunity and Immunopathology,,63365,IHD,Immunity and Host Defense Study Section,,5,337499,
7758735,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI063430-05,,NIAID:598172;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,059709394,US,MA,02115,"IMMUNE DISEASE INSTITUTE, INC.","LIEBERMAN, JUDY ;",1876917;,5R01AI063430,02/15/2006,01/31/2011,"Apoptosis; Apoptosis Pathway; Apoptotic; Bacteria; Basophilic Granulocyte; Basophilic Leukocyte; Basophils; Binding; Binding (Molecular Function); Biochemical; Blood (Leukemia); Blood Basophil; Blood Coagulation Factor IV; C2 Domain; CTL; CURL; Ca++ element; Calcium; Caliber; Cell Death; Cell Death, Programmed; Cell membrane; Cell-Mediated Lympholytic Cells; Cells; Cellular Membrane; Cellular biology; Characteristics; Clotting; Coagulation; Coagulation Factor IV; Coagulation Process; Collaborations; Coloring Agents; Common Rat Strains; Compartment of the Uncoupling Receptors and Ligands; Complement; Complement Proteins; Cytolysis; Cytolytic T-Cell; Cytoplasmic Granules; Cytoplasmic Membrane; Cytosol; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; Data; Dephosphin; Diameter; Doctor of Philosophy; Dyes; Dynamin; Early Endosome; Effector Cell; Electron Microscopy; Electrons; Endocytosis; Equilibrium; Exocytosis; Factor IV; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Granzyme; Human; Human, General; Image; Immune response; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Investigators; K lymphocyte; Label; Laboratories; Lecithinase C; Leukemias, General; Lysis; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Basophil; Mediating; Membrane; Mice; Modeling; Molecular Interaction; Molecular Weight; Murine; Mus; Mutation; NK Cells; Natural Killer Cells; Necrosis; Necrotic; Negative Beta Particle; Negatrons; Pathway interactions; Ph.D.; PhD; Phospholipase C; Plasma Membrane; Process; Protein Binding; Proteins; Proteoglycan; Rat; Rattus; Recombinants; Reporting; Research Personnel; Researchers; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Staining method; Stainings; Stains; Structure; System; System, LOINC Axis 4; T-Lymphocyte and NK-Cell; T-Lymphocyte and Natural Killer Cell; T-Lymphocytes, Cytotoxic; Testing; Time; Transfection; VESCL; Vesicle; Virus; Viruses, General; Work; Wound Healing; Wound Repair; balance; balance function; base; cell biology; cytolysin; cytotoxic; experiment; experimental research; experimental study; familial hemophagocytic lymphohistiocytosis; gene product; genome mutation; granule; host response; imaging; immunological synapse; immunoresponse; immunosuppressed patient; leukemia; lipophosphodiesterase I; lymphocyte pore-forming protein; membrane structure; mutant; necrocytosis; pathway; perforin; phosphatidylcholine cholinephosphohydrolase; plasmalemma; repair; repaired; research study; response; synaptotagmin; syt (synaptotagmin); tissue repair; trafficking; tumor",Mechanism of perforin activity,,63430,CMI,Cellular and Molecular Immunology - A,,5,598172,
7791415,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI063441-05,,NIAID:357172;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MILWAUKEE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"FRANK, DARA W.;",1881991;,5R01AI063441,02/15/2006,01/31/2011,"Adherence; Adherence (attribute); Animal Model; Animal Models and Related Studies; Animals; Attenuated Vaccines; Bacteria; Biological; CDC; Candidate Disease Gene; Candidate Gene; Categories; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Clinical; Cues; DNA; Deoxyribonucleic Acid; Dose; E coli; Epithelium; Escherichia coli; Eye; Eyeball; F. tularensis; Francisella; Francisella tularensis; Future; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Generalized Growth; Genes; Genes, Regulator; Genetic; Goals; Growth; Head and Neck, Pharynx; Human; Human, General; In Vitro; Infection; Knock-out; Knockout; Licensing; Lung; Mammals, Rabbits; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Modeling; Nature; Organism; Oryctolagus cuniculus; Parasites; Pasteurella tularensis; Pathway interactions; Pharyngeal structure; Pharynx; Pharynxs; Phenotype; Plasmid Cloning Vector; Plasmid Vector; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Rabbit, Domestic; Rabbits; Regulator Genes; Regulatory Pathway; Reporter; Reporting; Respiratory System, Lung; Rodent; Rodentia; Rodentias; Series; Severity of illness; Skin; Symptoms; System; System, LOINC Axis 4; Techniques; Technology; Throat; Tissue Growth; Transcriptional Regulatory Elements; Tularemia; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Vaccines; Vaccines, Attenuated; Virulence; Virulent; attenuation; density; disease severity; gene product; in vivo; interest; live vaccine; living system; macrophage; model organism; mouse model; mutant; ontogeny; pathogen; pathway; programs; pulmonary; regulatory gene; response; therapeutic target; tissue culture; tool; trafficking; trans acting element; uptake; vaccine development; weapons",Regulation of Gene Expression in Francisella,,63441,BACP,Bacterial Pathogenesis Study Section,,5,357172,
7760853,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI063446-05,,NIAID:396072;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"EHRT, SABINE ;",6790899;,5R01AI063446,02/15/2006,01/31/2011,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; Address; Anti Mycobacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antimycobacterial Agents; Antitubercular Agents; Antitubercular Drugs; Assay; Bioassay; Biologic Assays; Biological Assay; C element; Carbon; Cause of Death; Cessation of life; Chronic Phase; Communicable Diseases; Communities; D-Glucose; Death; Development; Dextrose; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Drug Therapy; Drugs; Essential Genes; Evaluation; Fatty Acids; Gene Expression; Gene Inactivation; Gene Silencing; Generalized Growth; Genes; Genes, Essential; Genes, Reporter; Genus Mycobacterium; Gluconeogenesis; Glucose; Glycerin; Glycerol; Glycolysis; Growth; In Vitro; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Knock-out; Knockout; Lead; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Mammals, Mice; Medication; Metabolic; Metabolic Pathway; Methods; Mice; Miscellaneous Antibiotic; Molecular; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Mycobacterium; Mycobacterium tuberculosis; Nutrient; Pathogenesis; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Regulation; Reporter Genes; Research; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Source; System; System, LOINC Axis 4; Tet; Tetanus Helper Peptide; Tetracycline Antibiotic; Tetracyclines; Time; Tissue Growth; Tuberculosis; Tuberculostatic Agents; Validation; Work; anti-tuberculosis; antimycobacterial; antituberculosis; chemotherapy; disease/disorder; disseminated TB; disseminated tuberculosis; drug/agent; experiment; experimental research; experimental study; functional genomics; gene induction; glucose biosynthesis; heavy metal Pb; heavy metal lead; in vivo; insight; macrophage; multi-drug resistant; multidrug resistant; mutant; mycobacterial; novel; ontogeny; pathogen; research study; social role; tool; tuberculosis drugs; tuberculous spondyloarthropathy",Conditional Expression of Mycobacterial Genes,,63446,HIBP,Host Interactions with Bacterial Pathogens Study Section,,5,396072,
7754427,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI063503-05,,NIAID:269001;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TORRANCE,UNITED STATES,,36,069926962,US,CA,90502,LA BIOMED RES INST/ HARBOR UCLA MED CTR,"IBRAHIM, ASHRAF S.;",6843417;,5R01AI063503,02/01/2006,01/31/2011,"Affect; Affinity; Aging; Angioinvasion; Animal Model; Animal Models and Related Studies; Animals; Antifungal Therapy; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Blood Vessels; Cancers; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular injury; Chelating Agents; Chelators; Clinical; Clinical, Transplantation, Organ; Complement; Complement Proteins; Complexons; Debridement; Development; Diabetes Mellitus; Diabetic Acidosis; Diabetic Ketoacidosis; Diabetic mouse; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Dysfunction; Elements; Endothelial Cells; Environment; Fe element; Functional disorder; Generations; Genes; Grafting Procedure; Hematogenous; Heterophil Granulocyte; Histology; Host Defense; Immune response; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Vitro; Incidence; Infection; Invaded; Investigation; Investigators; Iron; Iron Overload; Ketosis, Diabetic; Life; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Neutrophil; Mediating; Medication; Methods; Methods and Techniques; Methods, Other; Mice; Modeling; Mortality; Mortality Vital Statistics; Mucormycosis; Murine; Mus; Mutagenesis, Site-Directed; Neutropenia; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Operation; Operative Procedures; Operative Surgical Procedures; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Organism; Oryza; Pathogenesis; Pathogenicity; Patients; Penetration; Phagocytes; Phagocytic Cell; Phagocytosis; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Predisposition; Prevalence; Process; Production; Programs (PT); Programs [Publication Type]; Receptor Protein; Reporting; Research Personnel; Researchers; Rhizopus; Risk; Risk Factors; Role; Senescence; Serum; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Steroid Compound; Steroids; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; Targeted DNA Modification; Targeted Modification; Techniques; Testing; Time; Toxic effect; Toxicities; Transplantation Surgery; United States; Virulence; amebocyte; cell damage; cell injury; clinical relevance; clinically relevant; cultured cell line; cytokine; diabetes; diabetic ketoacidotic; disease/disorder; drug/agent; fungus; genetic manipulation; host response; immunoresponse; immunosuppressed patient; in vivo; in vivo Model; iron metabolism; living system; malignancy; model organism; mouse model of diabetes; mutant; neoplasm/cancer; neutrophil; non-diabetic; nondiabetic; novel; organ allograft; organ graft; organ xenograft; pathophysiology; permease; prevent; preventing; process optimization; programs; reactive oxygen intermediate; receptor; response; senescent; social role; surgery; tissue tropism; treatment of fungal infectious disease; uptake; vascular",Iron Uptake and Mucormycosis Pathogenesis,,63503,PTHE,Pathogenic Eukaryotes Study Section,,5,269001,
7754686,R01,AI,5,,02/01/2010,01/31/2011,PA-03-080,5R01AI063516-05,,NIAID:302358;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GREENVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,607579018,US,NC,27858,EAST CAROLINA UNIVERSITY,"ROOP, ROY M;",1899294;,5R01AI063516,02/01/2006,01/31/2011,"Attenuated; Attenuated Vaccines; B. abortus; B. melitensis; B.abortus; B.melitensis; Bacteria; Biological Terrorism; Bioterrorism; Blood erythrocyte; Blood normocyte; Bordetella; Brucella; Brucella abortus; Brucella abortus bacterium; Brucella melitensis; Brucella melitensis bacterium; Brucella melitensis biovar abortus; Brucellosis; Cells; Cellular injury; Chemistry; Development; Disease; Disorder; Environment; Erythrocytes; Erythrocytic; Eukaryota; Eukaryote; Exhibits; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; GeneHomolog; Genes; Genetic; Genome; Goals; Gram-Negative Bacteria; Heme; Heme Iron; Heme b; Hemoglobin; Homolog; Homologous Gene; Homologue; Human; Human, General; Hydroxyl; Hydroxyl Radical; In Vitro; Investigators; Iron; Life; Link; Malta Fever; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mice; Microbe; Murine; Mus; Nature; Phagocytes; Phagocytic Cell; Physiologic; Physiological; Play; Process; Production; Programs (PT); Programs [Publication Type]; Prokaryotae; Prokaryotic Cells; Proteins; Protoheme; Protoheme IX; Recycling; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Relative; Relative (related person); Repression; Research; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Erythrocytes; Role; S. dysenteriae; Science of Chemistry; Shigella dysenteriae; Shigella dysenteriae bacterium; Source; Study Section; Survey Instrument; Surveys; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicities; Undulant Fever; Vaccines; Vaccines, Attenuated; Virulence; aged; amebocyte; base; blood corpuscles; cell damage; cell injury; deprivation; disease/disorder; eukaryotida; experience; ferroheme; gene product; heme a; insight; iron metabolism; live vaccine; macrophage; meetings; microbial; mouse model; mutant; novel; pathogen; prevent; preventing; programs; prokaryote; public health relevance; residence; resistant; social role; uptake; vaccine candidate",Brucella Iron Metabolism in Host Macrophages,,63516,BACP,Bacterial Pathogenesis Study Section,,5,302358,
7758806,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI063520-04,,NIAID:352937;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IOWA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"VARGA, STEVEN M;",1958380;,5R01AI063520,02/15/2007,01/31/2012,"0-11 years old; Address; Aged 65 and Over; Antigenic Determinants; BALB/c; Binding Determinants; Biological Models; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cells; Cells, CD4; Child; Child Youth; Children (0-21); Data; Development; Disease; Disorder; Elderly; Elderly, over 65; Eosinophilia; Epitopes; Epitopes, T-Lymphocyte; Exhibits; Exposure to; FLR; Failure (biologic function); Formalin; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Human; Human, Child; Human, General; Immune; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inactivated Vaccines; Inactivated Virus Vaccine; Inbred BALB C Mice; Individual; Infant; Infection; Injury; LYT3; Lower Respiratory Tract Infection; Lung; Lung Inflammation; Lung diseases; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Mice; Mice, Inbred BALB C; Model System; Models, Biologic; Mouse, BALB C; Murine; Mus; Poxvirus officinale; Prevention; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Eosinophilia; RSV Vaccines; Respiratory Disease; Respiratory Disorder; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory syncytial virus; Role; Sensitization, Immunologic; Sensitization, Immunological; Severities; T-Cell Epitopes; T-Cells; T-Lymphocyte; T-Lymphocyte Epitopes; T4 Cells; T4 Lymphocytes; Testing; Th-2 Cell; Th2 Cells; Thymus-Dependent Lymphocytes; Time; Type 2 Helper Cell; Vaccination; Vaccines; Vaccines, Inactivated; Vaccines, Killed; Vaccinia virus; Viral; Work; advanced age; children; cytokine; design; designing; disease/disorder; elders; failure; geriatric; glycoprotein G; helper T cell; human disease; immunopathology; late life; later life; lung disorder; memory CD4 T cell; memory CD4 T lymphocyte; mouse model; new approaches; novel approaches; novel strategies; novel strategy; older adult; older person; prevent; preventing; pulmonary; recombinant vaccinia virus; response; senior citizen; social role; thymus derived lymphocyte; youngster",Immunopathology mediated by RSV-specific CD4 T cells,,63520,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,4,352937,
7761710,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI064218-05,,NIAID:370492;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,VETERINARY SCIENCES,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"TELFORD, SAM R.;",1875793;,5R01AI064218,02/01/2006,01/31/2011,"Acute; Animals; Biological; Biology; Body Tissues; Cell/Tissue, Immunohistochemistry; Common Rat Strains; Competence; Cyst; Desiccation; Dessication; Disease Outbreaks; Environment; F. tularensis; Fever; Francisella tularensis; Genotype; Goals; Hematogenous; Hereditary; Histopathology; Hydrogen Oxide; Hyperthermia; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Infection; Inherited; Island; Ixodida; Lateral; Maintenance; Maintenances; Mammals, Mice; Mammals, Rabbits; Mammals, Rats; Mammals, Rodents; Measures; Mice; Minisatellite Repeats; Minisatellites; Murine; Mus; Nature; Oryctolagus cuniculus; Outbreaks; Outcome; Pasteurella tularensis; Prevalence; Protozoa; Protozoal; Pulmonary Pathology; Pyrexia; Rabbit, Domestic; Rabbits; Rat; Rattus; Resistance; Risk; Rodent; Rodentia; Rodentias; Simple Repetitive Sequence; Simulate; Site; Stress; Structure; Testing; Ticks; Tissues; Transmission; Tularemia; VNTR; VNTR Loci; VNTR Region; VNTR Sequences; Variable Number of Tandem Repeats; Variable Tandem Repeats; Variant; Variation; Virulence; Virulent; Water; base; cytokine; enzootic; epizootic; febrile; febris; genetic variant; human disease; mRNA Expression; pathogen; resistant; transmission process; vector",Perpetuation of Francisella tularensis,,64218,ZRG1,Special Emphasis Panel,,5,370492,
7761295,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI064743-04,,NIAID:362983;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MINNEAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"GENG, JIAN-GUO ;",7740720;,5R01AI064743,02/01/2007,01/31/2012,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Acute-Phase Proteins; Adhesion Molecule; Adhesions; Amino Acids; Amyloid P Component; Applications Grants; Attenuated; Beta 2 Integrin Chain; Binding; Binding (Molecular Function); Biological; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; CD11a Beta Subunit; CD11b Beta Subunit; CD11c Beta Subunit; CD162 antigen; CD18; CD18 Antigens; CD62; CD62P; CD62P Antigens; CR3; CR3 Receptor; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; Cells; Coagulation Factor I; Coagulation Factor One; Complex; Cytokines, Chemotactic; Cytoplasmic Domain; Cytoplasmic Tail; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Event; Extracellular Matrix, Integrins; Factor I; Factor One; Feedback; Fibrinogen; GMP-140; GMP140; GRMP; Grant Proposals; Grants, Applications; HL-60 Cells; HL60 Cells; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Hour; Human; Human, General; ICAM; INFLM; ITGB2; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; In Situ; In Vitro; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Integrin Beta-2; Integrin alpha-M beta-2; Integrin alphaMbeta2; Integrin beta2; Integrins; Intercrines; Intracellular Communication and Signaling; Knockout Mice; LECAM-3; LFA-1/CR3/P150, 959 Beta Subunit Precursor; Leukocyte Rolling; Leukocytes; Liver Cells; Lymphocyte Function-Associated Cell Surface Adhesion Glycoprotein; Mac 1; Mac-1 Adhesive Receptor; Mac-1 Antigen; Mac-1 Receptor; Macrophage-1 Antigen; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular; Molecular Interaction; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; P-Selectin; P-selectin glycoprotein ligand-1; P-selectin ligand protein; PADGEM; PI-3 Kinase; PI-3K; PI3-Kinase; PSEL; PSGL-1; Peritoneal; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Platelet alpha-Granule Membrane Protein; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prevention; Proteins; PtdIns 3-Kinase; Reactants, Acute-Phase; Receptor, Complement 3; Receptor, Mo1 Antigen; Receptor, Mo1 Glycoprotein; Recruitment Activity; Regulation; Rest; Reticuloendothelial System, Leukocytes; Role; SELP; SELP gene; SIS cytokines; Selectin P Gene; Serum Amyloid P-Component; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Testing; Transcription Factor NF-kB; Transgenic Mice; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; White Blood Cells; White Cell; aminoacid; biological signal transduction; cell adhesion protein; chemoattractant cytokine; chemokine; cross-link; crosslink; disease/disorder; extracellular; gene product; in vivo; inhibitor; inhibitor/antagonist; intercellular cell adhesion molecule; kappa B Enhancer Binding Protein; mutant; neutrophil; new therapeutic target; nuclear factor kappa beta; p150,95 beta-Subunit; recruit; response; social role; white blood cell; white blood corpuscle",Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling,,64743,ELB,Erythrocyte and Leukocyte Biology Study Section,,4,362983,
7775111,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI064893-04,,NIAID:367643;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,GENETICS,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"WEISS, ALISON A.;",1892978;,5R01AI064893,03/01/2007,02/28/2012,"1H-Purin-6-amine; Address; Adenine; Affect; Amino Acids; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Baboons; Bacteriophages; Binding; Binding (Molecular Function); Bizzozero's corpuscle/cell; Blood Neutrophil; Blood Platelets; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Burkitt's lymphoma antigen, BLA-CD77; CD77 antigen; Cell Culture Techniques; Cells; Cessation of life; Cleaved cell; Clinical; Clotting; Coagulation; Coagulation Process; Colitis; Complication; Death; Deetjeen's body; Development; Diarrhea; Disease; Disorder; Dose; E coli O157; EHEC; EHEC, Escherichia coli; Effector Cell; Endothelial Cells; Enterohemorrhagic E coli; Enterohemorrhagic E. coli; Enterohemorrhagic E.coli; Enterohemorrhagic Escherichia coli; Enterohemorrhagic strain of E coli; Enterohemorrhagic strain of E. coli; Enterohemorrhagic strain of Escherichia coli; Escherichia coli EHEC; Escherichia coli O157; Event; Family; Gal-1-4-Gal-1-4-Glc-cer; Ganglioside GA3, O-alpha-D-galactopyranosyl-(1-4B)-; Gasser's Syndrome; Gb3 globotriaosylceramide; Gb3Cer; Gene Expression; Genes; Hayem's elementary corpuscle; Hemolytic-Uremic Syndrome; Heterophil Granulocyte; Host Factor; Host Factor Protein; Hybrids; Immune; In Vitro; Incidence; Infection; Inflammation Mediators; Integration Host Factors; Intestinal; Intestines; Investigators; Kidney; Lead; Life; Life Cycle; Life Cycle Stages; Link; Lytic Cycle; Lytic Infection; Lytic Phase; Marrow Neutrophil; Marrow platelet; Miscellaneous Antibiotic; Modeling; Molecular; Molecular Interaction; N glycosidase; Neutrophilic Granulocyte; Neutrophilic Leukocyte; P(K) antigen; Papio; Papios; Pathogenesis; Pathogenicity Factors; Pb element; Peptide Biosynthesis, Ribosomal; Phages; Platelets; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Production; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; RNA, Ribosomal, 28S; Recruitment Activity; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Platelets; Ribosomes; Role; STEC; Savanna Baboons; Severity of illness; Shiga Toxin; Shiga toxin receptor; Shiga toxin-producing E coli; Shiga toxin-producing E. coli; Shiga toxin-producing E.coli; Shiga toxin-producing Escherichia coli; Shigella Cytotoxin; Shigella Toxin; Site; Stx Protein; Stx Protein, Shigella dysenteria; Thrombocytes; Toxic effect; Toxicities; Toxin; United States; Urinary System, Kidney; VT2 receptor; Variant; Variation; Viral; Virulence Factors; Virus; Viruses, General; Vitamin B4; aminoacid; bacterial virus; base; bowel; carbohydrate receptor; cleaved; cytokine; disease severity; disease/disorder; galactosyl(alpha1-4)galactosyl(beta1-4)glucosylceramide; globotriaosylceramide; globotriasoyl ceramide; globotriosylceramide; heavy metal Pb; heavy metal lead; in vivo; life course; member; mouse model; mutant; neutrophil; pathogen; programs; protein bound carbohydrate; protein synthesis; receptor binding; recruit; renal; social role; thrombocyte/platelet",Shiga Toxin Production and Role in Pathogenesis,,64893,BACP,Bacterial Pathogenesis Study Section,,4,367643,
7764641,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI065539-05,,NIAID:333124;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"HENDRIXSON, DAVID R;",1904067;,5R01AI065539,02/15/2006,01/31/2011,"2PP2A; Alimentary Canal; Anabolism; Animals; Attention; Aves; Avian; Bacteria; Bacterial Gastroenteritis; Birds; C. jejuni; C.jejuni; Campylobacter jejuni; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cellular Migration; Coliform Bacilli; Data; Digestive Tract; Disease; Disorder; Elements; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Flagella; GI Tract; GTP Phosphohydrolases; GTPases; Gastroenteritis; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic; Genetic Transcription; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HLA-DR Associated Protein II; Human; Human, General; I2PP2A; IGAAD; In Vitro; Inhibitor of GZMA-Activated DNase; Intracellular Communication and Signaling; Knowledge; Man (Taxonomy); Man, Modern; Membrane; Motility; Motility, Cellular; NtrA protein; Organism; PHAPII; Pathogenesis; Pathway interactions; Phase; Phosphatase 2A Inhibitor I2PP2A; Prevalence; Production; Proteins; RNA Expression; RNA polymerase sigma 54; Regulation; Regulatory Pathway; Regulatory Protein; Research; Research Activity; Role; RpoN protein; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; SRP; Set protein; Signal Recognition Particle; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Surface; Symbiosis; Syndrome; System; System, LOINC Axis 4; TAF-IBETA; TF sigma-54; Technology; Template Activating Factor I Beta; Testing; Transcription; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription, Genetic; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Up-Regulation; Virulence; alimentary tract; biological signal transduction; biosynthesis; cell motility; commensal bacteria; commensal microbes; commensalism; digestive canal; disease/disorder; experiment; experimental research; experimental study; food-born; food-borne; foodborn; foodborne; gene product; genetic regulatory protein; guanosinetriphosphatase; in vivo; living system; membrane structure; mutant; pathogen; pathway; regulatory gene product; research study; sigma factor 54; sigma(54); sigma(N); sigma54; social role; tool; transcription factor sigma-54",Campylobacter jejuni flagellar regulation and synthesis,,65539,BACP,Bacterial Pathogenesis Study Section,,5,333124,
7758764,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065617-10,,NIAID:345663;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,PEDIATRICS,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"CHATILA, TALAL AMINE;",1903409;,5R01AI065617,08/01/1998,01/31/2011,"ATGN; Address; Airway Hyper-responsiveness; Allergic; Allergic inflammation; Antibodies, Enhancing; Antibody Formation; Antibody Production; Antibody Response; Antigens; Apoptotic; Asthma; Attenuated; B blood cells; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binding; Binding (Molecular Function); Binetrakin; Body Tissues; Bronchial Asthma; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD124 Antigens; CDw124 Antigen; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Chronic; Enhancing Antibodies; Epithelial Cells; Event; Evolution; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetics-Mutagenesis; Goblet Cells; IL-13; IL-4; IL13; IL4; IL4 Protein; IL4 Receptors; ITIM; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Immunoreceptor Tyrosine-Based Inhibitory Motif; Inflammatory Response; Interleukin 4 Receptor; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Interleukin-4 Receptor Alpha; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; L-Phenylalanine; L-Tyrosine; Ligands; Lymphocyte Stimulatory Factor 1; MCGF-2; Mammals, Mice; Mast Cell Growth Factor-2; Mediating; Medical; Memory; Metaplasia; Metaplastic Change; Mice; Mice, Mutant Strains; Microarray Analysis; Microarray-Based Analysis; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutant Strains Mice; Mutation; Phenylalanine; Phenylalanine, L-Isomer; Play; Polymorphism (Genetics); Polymorphism, Genetic; Receptor Signaling; Receptor, B Cell-Activating Factor; Receptors, IL-4; Regulation; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stream; T-Cell Growth Factor 2; TYR; Targetings, Gene; Testing; Tissues; Transgenic Animals; Tyrosine; Tyrosine, L-isomer; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; allergic airway epithelium inflammation; allergic airway inflammation; antibody biosynthesis; base; biological signal transduction; genome mutation; hypoimmunity; immune deficiency disorder; immunodeficiency; immunogen; immunoglobulin biosynthesis; in vivo; interventional strategy; microarray technology; mouse mutant; mutant; novel; para-Tyrosine; polymorphism; response; social role; transcription factor",Molecular Basis of Hyper lgE Immunodeficiency,,65617,CMI,Cellular and Molecular Immunology - A,,10,345663,
7756609,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065702-05,,NIAID:340656;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HERSHEY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"BONNEAU, ROBERT H.;",1872543;,5R01AI065702,02/01/2006,01/31/2011,"ATGN; Address; Affect; Antigen Presentation; Antigen Presentation Pathway; Antigen Processing; Antigen Processing and Presentation; Antigen Processings; Antigens; Antiviral Agents; Antiviral Drugs; Antivirals; Applications Grants; Area; Bacterial Infections; CD8; CD8B; CD8B1; CD8B1 gene; CTL; Cell Function; Cell Maturation; Cell Process; Cell physiology; Cell surface; Cell-Mediated Lympholytic Cells; Cells; Cellular Function; Cellular Physiology; Cellular Process; Class I Antigens; Class I Major Histocompatibility Antigens; Complex Class 1; Corticosterone; Cross Presentation; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Dendritic Cells; Development; Disease; Disorder; Ensure; Event; Foundations; Generations; Genes, Class I; Genes, MHC Class I; Glucocorticoids; Goals; Grant Proposals; Grants, Applications; HPA; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesvirus hominis; Histocompatibility Antigens Class I; Immune; Immune Function, Cellular; Immune response; Immunity; Impairment; In Vitro; Infection; Investigators; Knowledge; LYT3; Link; Lymphocyte; Lymphocyte Function; Lymphocytic; MHC Class I; MHC Class I Genes; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; Major Histocompatibility Complex Class 1; Mammals, Mice; Mediating; Memory; Mice; Molecular; Molecular Transport; Murine; Mus; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Pathway interactions; Peptides; Phenotype; Play; Predisposition; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Process; Production; Programs (PT); Programs [Publication Type]; Psychological Stress; Publishing; Qualifying; Reagent; Refractory; Regulation; Research; Research Personnel; Researchers; Role; SNS; Simplexvirus; Stress; Stress, Psychological; Subcellular Process; Susceptibility; Sympathetic Nervous System; T-Cells; T-Lymphocyte; T-Lymphocytes, Cytotoxic; Testing; Therapeutic Glucocorticoid; Thymus-Dependent Lymphocytes; Time; Transport Process; Vaccination; Veiled Cells; Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; Work; antigen processing; bacterial disease; cell type; disease/disorder; experience; herpesvirus; host response; human herpesvirus 1 group; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; immune function; immunogen; immunoresponse; in vivo; innovate; innovation; innovative; lymph cell; pathogen; pathway; peptide hormone; programs; response; social role; thymus derived lymphocyte; tumor; uptake; vaccination strategy; viral infection; virus infection",Glucocorticoid/Stress Effects on Dendritic Cell Function,,65702,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,5,340656,
7759217,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI065760-05,,NIAID:315089;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PEDIATRICS,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"PASETTI, MARCELA F;",1999015;,5R01AI065760,02/01/2006,01/31/2011,"0-11 years old; 0-6 weeks old; 21+ years old; ATGN; Achyrocline; Adjuvant; Adult; Aerosols; Age; Age Group Unspecified; Aged 65 and Over; Anthrax Attack; Anthrax Vaccines; Anthrax spore; Antibodies; Antigens; Area; Armed Forces Personnel; Attenuated; B. anthracis; B. anthracis spore; Bacillus anthracis; Bacillus anthracis spore; Bacteria; BioPort brand of anthrax vaccine; Biological Terrorism; Bioterrorism; Biothrax; Body Tissues; CAPS; Capsules; Cell Function; Cell Isolation; Cell Maturation; Cell Mediated Immunology; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell physiology; Cell-Mediated Immunity; Cellular Function; Cellular Immunity; Cellular Physiology; Cellular Process; Child; Child Youth; Childhood; Children (0-21); Color; Cytofluorometry, Flow; Data; Dendritic Cells; Development; Diphtheria; Disease; Disorder; Distress; Dose; Elderly; Elderly, over 65; Emergencies; Emergency Situation; Equilibrium; Event; Flagella; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Generations; Goals; Hepatitis B; Hepatitis B Infection; Human; Human, Adult; Human, Child; Human, General; Immune; Immune Function, Cellular; Immune response; Immune system; Immunity; Immunity, Cellular; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunization; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Immunosuppressed Host; In Vitro; Individual; Infant; Infant, Newborn; Infection; Investigators; Knowledge; LPS; Life; Link; Lipopolysaccharides; Mails; Mammals, Mice; Man (Taxonomy); Man, Modern; Marcela; Maternal antibody; Mediating; Mice; Microfluorometry, Flow; Military; Military Personnel; Modeling; Mothers; Murine; Mus; Natural Immunity; Neonatal; Newborn Infant; Newborns; Organism; Pasteurella pestis; Pertussis; Plague; Plasmids; Population; Preparedness; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Public Health; Readiness; Regimen; Relative; Relative (related person); Research; Research Personnel; Researchers; Risk; S. typhi; S. typhosa; S.Typhi; Safety; Salmonella; Salmonella Vaccines; Salmonella enterica serovar Typhi; Salmonella typhi; Salmonella typhosa; Salmonellosis Vaccines; Sensitization, Immunologic; Sensitization, Immunological; Subcellular Process; Subunit Vaccines; System; System, LOINC Axis 4; T memory cell; T-Cell Activation; Tern; Testing; Tetanus; Time; Tissues; United States; Vaccinated; Vaccination; Vaccine Antigen; Vaccines; Vaccines, Subunit; Veiled Cells; Viral Hepatitis B; Virulent; Vulnerable Populations; Whooping Cough; Y. pestis; Y.pestis; Yersinia pestis; Yersinia pestis disease; abstracting; adult human (21+); advanced age; age group; anthracis; anthracis spore; balance; balance function; base; biodefense; body system, allergic/immunologic; capsule (pharmacologic); cell mediated immune response; cell sorting; children; clostridial tetanus; cytokine; disease/disorder; elders; flow cytophotometry; geriatric; high risk; host response; immune function; immunogen; immunogenic; immunogenicity; immunoresponse; immunosuppressed patient; improved; in vivo; late life; later life; living system; memory T lymphocyte; mouse model; neonate; newborn human (0-6 weeks); older adult; older person; oral vaccine; organ system, allergic/immunologic; pathogen; pediatric; physical conditioning; plasmid vaccine; preclinical study; prevent; preventing; programs; protective efficacy; public health medicine (field); pup; response; senior citizen; serum hepatitis; tool; vaccine candidate; vaccine delivery; vaccine development; vector; vector vaccine; weapons; youngster",Immune Responses to Biodefense Vaccines Early in Life,,65760,VMD,Vaccines Against Microbial Diseases Study Section,,5,315089,
7746474,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065791-05,,NIAID:304480;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WINSTON-SALEM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"MCCALL, CHARLES EMORY;",1884723;,5R01AI065791,02/01/2006,01/31/2011,"3-10C; AMCF-I; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Blotting, Western; Bp50; CD40; CDW40; CHIP assay; CXCL8; Cell Nucleus; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Co-Immunoprecipitations; Complex; Coupling; Critical Care; Cytosol; Data; Endotoxins; Event; Feedback; GCP-1; GCP1; Gene Transcription; Genes; Genetic Transcription; Genetic, Biochemical; Heterophil Granulocyte; Histone H3; Human; Human, General; IL-8; IL8; IL8 gene; Immune; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Infection; Inflammatory; Intensive Care Units; Investigators; Journals; K60; LECT; LUCT; LYNAP; Leukocytes; MDNCF; MGC9013; MOF syndrome; MONAP; Magazine; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Messenger RNA; Methylation; Modeling; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Organ Failure; NAF; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Natural immunosuppression; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nucleus; Organ Dysfunction Syndrome, Multiple; Participant; Phenotype; Phosphorylation; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Preparation; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Protein Phosphorylation; Publishing; RNA Expression; RNA, Messenger; RNA, Small Interfering; Reporting; Repression; Research; Research Personnel; Researchers; Reticuloendothelial System, Leukocytes; SCYB8; Sepsis; Small Interfering RNA; Specificity; Stress; TNFRSF5; TNFRSF5 gene; TSG-1; Testing; Time; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Transfection; Translating; Translatings; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Western Blotting; Western Blottings; Western Immunoblotting; White Blood Cells; White Cell; b-ENAP; bloodstream infection; chromatin immunoprecipitation; chromatin remodeling; design; designing; immunosuppression; kappa B Enhancer Binding Protein; language translation; mRNA; multiple organ system failure; neutrophil; novel; nuclear factor kappa beta; p50; p65; programs; protein blotting; public health relevance; siRNA; tool; white blood cell; white blood corpuscle",NF-kB and Chromatin Changes in Human Sepsis,,65791,IHD,Immunity and Host Defense Study Section,,5,304480,
7758351,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065850-05,,NIAID:299713;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"THOMAS, MICHAEL GEORGE;",6583598;,5R01AI065850,02/01/2006,01/31/2011,"Acid-Amino-Acid Ligases; Adverse effects; Amino Acids; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antitubercular Agents; Antitubercular Drugs; Biological; Capreomycin; Capromycin; Chemicals; Clinical; Development; Drug resistance; Drug usage; Drugs; Engineering; Engineerings; Florimycin; Genus Mycobacterium; HCV; Hepatitis C virus; Hepatitus C; Infection; Intramuscular Injections; Lead; Libraries; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Medication; Metabolic; Methods; Miscellaneous Antibiotic; Modification; Molecular Genetic; Molecular Genetics; Multidrug-Resistant Tuberculosis; Mycobacterium; Mycobacterium tuberculosis; Pathway interactions; Patients; Pb element; Peptide Synthetases; Pharmaceutic Preparations; Pharmaceutical Preparations; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Protocols, Treatment; RGM; Regimen; Reliance; Resistance; Series; Side; Source; Spinal Column; Spine; Structure; Synthesis Chemistry; Synthetic Chemistry; Treatment Protocols; Treatment Regimen; Treatment Schedule; Treatment Side Effects; Tuberactinomycin B; Tuberculosis; Tuberculosis, MDR; Tuberculosis, Multi-Drug Resistant; Tuberculosis, MultiDrug Resistance; Tuberculosis, Multidrug-Resistant; Tuberculostatic Agents; Vertebral column; Viomicin; Viomycin; acid aminoacid ligase; aminoacid; anti-tuberculosis; antituberculosis; backbone; chemical reaction; combat; disseminated TB; disseminated tuberculosis; drug development; drug resistant; drug use; drug/agent; heavy metal Pb; heavy metal lead; intramuscular administration of drug; pathway; peptide synthase; resistance to Drug; resistant; resistant strain; resistant to Drug; side effect; therapy adverse effect; treatment adverse effect; tuberactinomycin; tuberculosis drugs; tuberculosis treatment; tuberculous spondyloarthropathy",Discovering New Anti-Tuberculosis Drugs,,65850,ZRG1,Special Emphasis Panel,,5,299713,
7756575,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065853-05,,NIAID:386641;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"PRIGGE, SEAN TAYLOR;",7930712;,5R01AI065853,02/01/2006,01/31/2011,"2-Keto-4-Hydroxyglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase Complex; 2-Oxoglutarate[{..}]lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating); Abbreviations; Acetic acid, trichloro-; Active Oxygen; Acyl Carrier Protein; Albumins; Antioxidants; Bacteria; Binding; Binding (Molecular Function); Biochemical; Biological; Blood; Blood Serum; Blood erythrocyte; Blood normocyte; Cell Respiration; Cells; Cellular Respiration; Cellular biology; Cessation of life; CoA; Coenzyme A; Coenzymes; Cofactors, Enzyme; Communicable Diseases; Complex; Cytosol; Death; Dehydrogenases; Development; Digestion; Disease; Disorder; E coli; Enzymes; Erythrocytes; Erythrocytic; Escherichia coli; Fe element; Food; Generalized Growth; Genetic; Goals; Growth; Heme Iron; Hemoglobin; Housing; Human; Human, General; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intermediary Metabolism; Intestinal; Intestines; Investigators; Iron; Ketoglutarate Dehydrogenase Complex; Life; Ligase; Lipids; METBL; Malaria; Mammalia; Mammalian Cell; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Mitochondria; Molecular Genetic; Molecular Genetics; Molecular Interaction; Multienzyme Complexes; Nutrient; Organelles; Oxidoreductase; Oxoglutarate Dehydrogenase; Oxygen Radicals; Paludism; Parasites; Pathway interactions; Phosphate Buffer; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Proteins; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reductases; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Role; Saline; Saline Solution; Serum; Serum Albumin; Staging; Stream; Synthetases; Therapeutic Intervention; Tissue Growth; Trichloroacetic Acid; aerobic metabolism; aerobic respiration; alpha-Ketoglutarate Dehydrogenase; alpha-Ketoglutarate Dehydrogenase Complex; anti-oxidant; asexual; base; blood corpuscles; bowel; cell biology; coenzyme analog; cofactor; disease/disorder; enzyme complex; experiment; experimental research; experimental study; fatty acid biosynthesis; gene product; inhibitor; inhibitor/antagonist; intervention therapy; lipoate; maltose-binding protein; mitochondrial; novel therapeutic intervention; ontogeny; oxidative damage; oxidative metabolism; pathway; prevent; preventing; programs; research study; social role; trafficking; uptake",Roles of Lipoate Pathways in Plasmodium Survival,,65853,PTHE,Pathogenic Eukaryotes Study Section,,5,386641,
7763815,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI065967-06,,NIAID:392964;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WYNNEWOOD,UNITED STATES,,06,125797084,US,PA,19096,LANKENAU INSTITUTE FOR MEDICAL RESEARCH,"DESSAIN, SCOTT KENDALL;",1934351;,5R01AI065967,02/15/2006,01/31/2011,"Amino Acid Sequence; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Antigens, Viral; Antiheparin Factor; Armed Forces Personnel; Assay; B blood cells; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; B-Cells; B-Lymphocytes; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood Platelet Factor IV; Blood platelet factor 4; Bontoxilysin; Botulin; Botulinum A Toxin; Botulinum Neurotoxin A; Botulinum Toxin Type A; Botulinum Toxins; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Categories; Cell Line; Cell Lines, Strains; CellLine; Chemokine (C-X-C motif) Ligand 4; Cloning; Cloning, Human; Clostridium Botulinum Toxin Type A; Clostridium botulinum A Toxin; Clostridium botulinum B toxin; Clostridium botulinum Toxins; Complex; D. pneumoniae; D.pneumoniae; Development; Differentiation Factor, B-Cell; Diplococcus pneumoniae; Epitopes; Factor 4; Gene Family; General Population; General Public; Glycans; HPGF; Heparin; Heparin Neutralizing Protein; Heparinic Acid; Hepatocyte-Stimulating Factor; Hu-mABs; Human; Human Cloning; Human, General; Hybridoma Growth Factor; Hybridomas; IFN-beta 2; IFNB2; IL-6; IL6 Protein; In Vitro; Individual; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Investigators; MGI-2; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mice; Military; Military Personnel; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Murine; Mus; Myeloid Differentiation-Inducing Protein; NIAID; Names; National Institute of Allergy and Infectious Disease; Neuromuscular Blockers; Neuromuscular Blocking Agents; PBL; Peripheral Blood Lymphocyte; Plasmacytoma Growth Factor; Platelet Factor 4; Pneumococcus; Polysaccharides; Poxvirus officinale; Process; Programs (PT); Programs [Publication Type]; Protein Structure, Primary; Protocol; Protocols documentation; Provincial Government; Publishing; Recombinant Platelet Factor 4; Research Personnel; Researchers; S. pneumoniae; Screening procedure; Seminal; Serotyping; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Somatic Mutation; Sorting - Cell Movement; Source; State Government; Streptococcus pneumoniae; Telomerase; Testing; Therapeutic; Therapeutic antibodies; Toxin; Toxoids; United States; Vaccinated; Vaccination; Vaccines; Vaccinia virus; Viral Antigens; Work; antibody biosynthesis; base; botulinum; botulinum B toxin; botulinum neurotoxin; botulinum neurotoxin B; botulinum toxin type B; chimeric antibody; cultured cell line; experiment; experimental research; experimental study; gamma-Thromboglobulin; human monoclonal antibodies; immunoglobulin biosynthesis; in vivo; interferon beta 2; neutralizing antibody; new therapeutics; next generation therapeutics; novel; novel therapeutics; platelet factor IV; programs; protein sequence; recombinant vaccinia virus; research study; response; screening; screenings; sorting; virus antigen; volunteer",Human Monoclonal Antibodies that Bind Botulinum Toxins,,65967,ZRG1,Special Emphasis Panel,,6,392964,
7769571,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI065974-05,,NIAID:348013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOUISVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"ABU KWAIK, YOUSEF A;",1881884;,5R01AI065974,03/01/2006,02/28/2011,"(S)-Lactate[{..}]NAD+ oxidoreductase; 1H,5H,11H,15H-Xantheno(2,3,4-ij[{..}]5,6,7-i'j')diquinolizin-18-ium, 9-(2(or 4)-(chlorosulfonyl)phenyl)-2,3,6,7,12,13,16,17-octahydro-; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); Abbreviations; Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Attenuated Vaccines; Bacteria; Biogenesis; Biological; Biological Terrorism; Bioterrorism; Blood monocyte; Categories; Cellular biology; Cytoplasm; Data; Degradation Pathway; Degradative Pathway; Disease; Disorder; EC 1.1.1.27; F. tularensis; Francisella; Francisella tularensis; Human; Human, General; Infection; Knowledge; L-Lactate Dehydrogenase; L-Lactic Acid Dehydrogenase; LDH; Lactate Dehydrogenase; Lysosomes; Man (Taxonomy); Man, Modern; Marrow monocyte; Molecular; NAD-Lactate Dehydrogenase; Nuclear; Organism; Origin of Life; Ovalbumin; Pasteurella tularensis; Pathogenesis; Pathogenicity Island; Phagosomes; Relative; Relative (related person); Route; Staging; TEM; Testing; Texas red; Therapeutic Intervention; Transmission Electron Microscopy; Tularemia; Vaccines, Attenuated; Vacuole; Virulent; adenylcyclase; cell biology; design; designing; disease/disorder; intervention therapy; lactic acid dehydrogenase; late endosome; live vaccine; living system; lysosomal proteins; macrophage; monocyte; mutant; novel; pathogen; pathogenic bacteria; sulforhodamine 101 acid chloride; sulforhodamine sulfonyl chloride; vaccination strategy; vaccine candidate; weapons",Molecular pathogenesis of Francisella tularnesis,,65974,HIBP,Host Interactions with Bacterial Pathogens Study Section,,5,348013,
7761193,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065982-05,,NIAID:314034;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,PATHOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"VIRGIN, HERBERT W;",1865936;,5R01AI065982,02/15/2006,01/31/2011,"Acids; Address; Antibodies; Antimorphic mutation; Attenuated; Australia; Bacterial Gastroenteritis; Binding; Binding (Molecular Function); Biology; Blood granulocytic cell; Bone Marrow; COS Cells; COS-1; COS-7 Cell; Calicivirus; Capsid; Capsid Proteins; Carbohydrates; Categories; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Surface Proteins; Cell Surface Receptors; Cell surface; CellLine; Cells; Cloning; Coat Proteins; Collaborations; Commit; Confocal Microscopy; Crystallographies; Crystallography; Cytoplasm; Data; Dendritic Cells; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drug usage; Effectiveness; Endocytosis; Enteral; Enteric; Environment; Epidemic; Event; Feces; Funding; Gastrointestinal Tract, Feces; Gene Products, RNA; Generalized Growth; Genes; Genome; Goals; Grant; Granular Leukocytes; Granulocytic cell; Growth; Hematopoietic; Herpesviridae; Herpesviruses; Human; Human, General; Hybridomas; Image; Immune; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Incus; Incus structure; Infection; Knowledge; Laboratories; Learning; Letters; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mice; Microscopy, Confocal; Moab, Clinical Treatment; Molecular; Molecular Interaction; Monoclonal Antibodies; Mononuclear; Murine; Mus; Natural Immunity; Nature; Norovirus; Norwalk Agent; Norwalk virus; Norwalk-like Viruses; Paper; Pathogenesis; Pathway interactions; Permissivenesses; Phagocytosis; Plaque Assay; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Cleavage; Proteins; Proteins, Cell Surface; Proteolysis; Qualifying; Queensland; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNA, Viral; RNAi; Receptor Protein; Receptors, Cell Surface; Receptors, Virus; Reovirus sp.; Reporting; Research; Research Design; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Role; Route; Science; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Structural Protein; Structure; Study Section; Study Type; System; System, LOINC Axis 4; Technology; Testing; Tissue Growth; Transfection; Tropism; Universities; Veiled Cells; Viral; Viral Coat Proteins; Viral Outer Coat Protein; Viral Receptor; Virion; Virulence; Virus; Virus Particle; Virus Receptors; Viruses, General; Washington; Work; base; coat (nonenveloped virus); cost; cultured cell line; drug use; experience; experiment; experimental research; experimental study; expression cloning; gene product; granulocyte; herpes virus; imaging; in vivo; macrophage; milligram; neutralizing mAb; neutralizing monoclonal antibodies; novel; ontogeny; pathogen; pathway; permissiveness; receptor; reovirus; research study; screening; screenings; social role; stool; study design; tissue culture; tool; viral RNA; virus RNA",Norovirus Infection of Dendritic Cells and Macrophages,,65982,VIRB,Virology - B Study Section,,5,314034,
7775108,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI065983-05,,NIAID:423450;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PHYSIOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"RAO, RAJINI ;",1959187;,5R01AI065983,03/01/2006,02/28/2011,"1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-; 1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-; Active Oxygen; Allergy; AmB; Amiodarone; Amphocil; Amphotec; Amphotercin B; Amphotercin B Deoxycholate; Amphotericin B; Anabolism; Animal Model; Animal Models and Related Studies; Anti-Arrhythmia Agents; Anti-Arrhythmia Drugs; Anti-Arrhythmics; Antiarrhythmia Agents; Antiarrhythmia Drugs; Antiarrhythmic Drugs; Antifungal Agents; Antifungal Drug; Antifungal Drug Resistance; Antifungal Drug Resistant; Antifungal resistant; Antioxidants; Apoptosis; Apoptosis Pathway; Apoptotic; Appearance; Aspergillus; Aspergillus fumigatus; Assay; Atrial Fibrillation; Auricular Fibrillation; Autoregulation; Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological; Biological Assay; Blood Coagulation Factor IV; C. albicans; C.albicans; Ca++ element; Calcineurin; Calcium; Candida; Candida albicans; Caspase Inhibitor; Caspofungin; Cell Death; Cell Death, Programmed; Cell membrane; Cell-Death Protease; Cells; Chelating Agents; Chelators; Chemicals; Clotrimazole; Coagulation Factor IV; Collection; Combined Modality Therapy; Complexons; Cryptococcus; Cryptococcus neoformans; Cytoplasmic Membrane; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Development; Disseminated candidiasis; Disseminated candidosis; Dose; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Resistance, Fungal; Drug Targeting; Drug Targetings; Drug resistance; Drug toxicity; Drug usage; Drugs; Endomycetales; Ergosta-5,7,22-trien-3-ol, (3beta,22E)-; Ergosterol; Event; Exhibits; Expression Profiling; Expression Signature; Factor IV; Ferricytochrome c; Ferrocytochrome c; Fluconazole; Fungal Drug Resistance; Fungicides, Therapeutic; Fungizone; Fungus Diseases; Fungus drug resistant; Generalized Growth; Generations; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Goals; Growth; Homeostasis; Hypersensitivity; ICE-like protease; In Vitro; Industrial fungicide; Intervention; Intervention Strategies; Investigators; Ion Channel; Ionic Channels; Itraconazole; Knock-out; Knockout; L-Serine; Lead; Libraries; Link; Mammals, Mice; Mediating; Medication; Membrane Channels; Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-; Mice; Miconazole; Microarray Analysis; Microarray-Based Analysis; Mitochondria; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Monilia; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Mutation; Mycoses; Oxygen Radicals; PP2B; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Plasma Membrane; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Protein Phosphatase-2B; Proteins; Proto-Oncogene, Signaling Factor; RT-PCR; RTPCR; Reactive Oxygen Species; Research Personnel; Researchers; Resistance; Reverse Transcriptase Polymerase Chain Reaction; S cerevisiae; Saccharomyces; Saccharomyces cerevisiae; Saccharomycetales; Serine; Signal Pathway; Signaling Pathway Gene; Sporanox; Systemic candida; Systemic candida infections; Systemic candidiasis; Testing; Time; Tissue Growth; Torula; Toxic effect; Toxicities; Vacuole; Ventricular Arrhythmia; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; analog; anti-fungal; anti-fungal drug resistance; anti-fungal drug resistant; anti-fungal resistance; anti-fungal resistant; anti-oxidant; antiarrhythmic agent; antifungal resistance; antifungals; arrhythmic agent; base; biosynthesis; caspase; clinical data repository; clinical data warehouse; combination therapy; combined modality treatment; combined treatment; cystein protease; cystein proteinase; cysteine endopeptidase; cytochrome c; data repository; diflucan; dronedarone; drug discovery; drug resistant; drug use; drug/agent; experiment; experimental research; experimental study; fungal infection; fungicidal; fungicide; fungus; fungus drug resistance; fungus infection; gene product; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; knockout gene; microarray technology; mitochondrial; mitochondrial membrane; model organism; molecuar profile; molecular signature; multimodality therapy; mutant; necrocytosis; novel; ontogeny; pathogen; pathway; plasmalemma; programs; public health relevance; relational database; research study; resistance to Drug; resistance to anti-fungal; resistance to antifungal; resistant; resistant to Drug; resistant to anti-fungal; resistant to antifungal; response; reverse transcriptase PCR; synergism; trafficking; weapons",Cellular Basis for the Antifungal Activity of Amiodarone,,65983,ZRG1,Special Emphasis Panel,,5,423450,
7761202,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI065985-05,,NIAID:286680;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"BLIGHT, KERIL J;",7645240;,5R01AI065985,02/01/2006,01/31/2011,"Acute; Affect; Biochemical; Biological Models; C-terminal; Carcinoma of the Liver Cells; Cell Culture System; Cell Culture Techniques; Charge; Chronic; Cirrhosis; Code; Coding System; Complex; DNA Helicases; DNA Unwinding Proteins; DNA unwinding enzyme; Data; Development; Drugs; Endoplasmic Reticulum; Ergastoplasm; Family; Fibrosis; Flaviviridae; Genetic; Genome; Goals; Grant; HCC; HCV; HCV infection; HCV-Hun NS3 protein; HCV-Hunan NS3 protein; Health; Hepatic Disorder; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Human; Human, General; Individual; Infection; L-Serine; Liver diseases; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane; Membrane Proteins; Membrane-Associated Proteins; Model System; Models, Biologic; Molecular; N-terminal; NANBH; NH2-terminal; NS3 protease, hepatitis C virus; NS3 protein, HCV; NS3 protein, hepatitis C virus; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoproteins; Phosphorylation; Play; Primary carcinoma of the liver cells; Protein Phosphorylation; Proteins; RNA Viruses; RNA replication; Role; Scheme; Serine; Structural Protein; Surface; Surface Proteins; Testing; United States; Variant; Variation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus Replication; Work; base; combat; design; designing; drug/agent; gene product; helicase; hepatitis C virus NS3 protein; hepatitis non A non B; hepatitis nonA nonB; hepatopathy; liver disorder; member; membrane structure; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; p70(NS3); social role; virus multiplication; virus protein",Defining NS4B Function in Hepatitis C Virus Replication,,65985,VIRB,Virology - B Study Section,,5,286680,
7766974,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI066013-04,,NIAID:410329;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"MALLEY, RICHARD ;",2108468;,5R01AI066013,03/01/2007,02/28/2012,"0-11 years old; 2 year old; ATGN; Active Immunization; Adoptive Transfer; Agonist; Antibodies; Antigens; Bacteria; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; CAPS; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CTLA-8; CTLA8; Capsules; Cells; Cells, CD4; Cessation of life; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Conflict; Conflict (Psychology); Confocal Microscopy; Conjugate Vaccines; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; D. pneumoniae; D.pneumoniae; Data; Death; Dendritic Cells; Development; Diplococcus pneumoniae; Disease; Disorder; Encapsulated; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Evaluation; Gamma interferon; Glycans; Goals; Grant; Heterophil Granulocyte; Human; Human, Child; Human, General; IFN-Gamma; IFN-g; IFNG; IL-17; IL-17A; IL17; IL17 Protein; IL17A; Immune response; Immunity; Immunization; Immunization Programs; Immunologic Stimulation; Immunologic Techniques; Immunological Stimulation; Immunological Technics; Immunological Techniques; Immunostimulation; Infant; Inflammatory; Injection of therapeutic agent; Injections; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Investigators; Killings; Knowledge; LYT3; Laboratories; Lymphatic Tissue; Lymphoid Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mediating; Mice; Microscopy, Confocal; Modeling; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pilum; Play; Pneumococcal Colonization; Pneumococcal Infections; Pneumococcal vaccine; Pneumococcus; Pneumonia; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Polysaccharides; Programs (PT); Programs [Publication Type]; Proteins; Pulmonary Inflammation; Receptor Protein; Refrigeration; Research Personnel; Researchers; Resistance; Resistance development; Resistant development; Role; S. pneumoniae; Sensitization, Immunologic; Sensitization, Immunological; Sepsis; Serotyping; Streptococcus pneumoniae; Streptococcus pneumoniae Infections; Streptococcus pneumoniae vaccine; T-Cell Development; T-Cell Ontogeny; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T4 Cells; T4 Lymphocytes; TLR protein; Technics, Immunologic; Testing; Thymus-Dependent Lymphocytes; Time; Toll-like receptors; Vaccines, Conjugate; Veiled Cells; Work; acquired immunity; base; bloodstream infection; capsule (pharmacologic); children; clinical investigation; cytokine; developing resistance; disease/disorder; experiment; experimental research; experimental study; extracellular; fimbriae; gene product; helper T cell; high risk; host response; human data; immunogen; immunoresponse; lFN-Gamma; neutrophil; new vaccines; next generation vaccines; novel; novel vaccines; pathogen; pilus; pneumococcal disease; pneumococcus infection; prevent; preventing; programs; receptor; research study; resistance mechanism; resistant; resistant mechanism; response; social role; success; thymus derived lymphocyte; two year old; youngster",Mechanisms of Immunity to Pneumococcal Colonization,,66013,HIBP,Host Interactions with Bacterial Pathogens Study Section,,4,410329,
7755817,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI066045-04,,NIAID:252087;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ALBUQUERQUE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"DURVASULA, RAVI V;",6489068;,5R01AI066045,02/15/2007,01/31/2011,"1,4-(1,3;1,4)-beta-D-Glucan-4-glucanohydrolase; Address; American Trypanosomiasis; American trypanosome; Antibodies; Antigenic Determinants; Area; Bacteria; Bacterial Physiology; Binding Determinants; Bombyx mori moricin protein; Cell Surface Glycoproteins; Cellulysin; Chagas Disease; Complementary DNA; DNA, Complementary; Development; Disease Vectors; Endo-1,4-beta-Glucanase; Endoglucanase; Enzymes; Epitopes; Future; Glycans; Glycoproteins; Immune; Insecta; Insects; Invertebrates, Insects; Mannosidase; Membrane Glycoproteins; Modeling; Molecular Target; Parasites; Peptides; Polysaccharides; Recombinants; Refractory; Resistance; Rhodnius; Rhodococcus; Risk Assessment; Site; South America; Surface; Surface Glycoproteins; System; System, LOINC Axis 4; T. cruzi; Testing; Toxic effect; Toxicities; Transgenic Organisms; Trypanosoma cruzi; Trypanosomiasis, South American; Vector (Infectious Agent); apidaecin; base; beta-1,4-Glucan-4-Glucanohydrolase; cDNA; cecropin A; cellulase; cost; lyticase; magainin; moricin; moricin protein, Bombyx mori; pesticide poisoning; pesticide toxicity; resistant; sugar; transgenic; vector",T. cruzi molecular targets for vector paratransgenesis,,66045,VB,Vector Biology Study Section,,4,252087,
7758257,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI066075-05,,NIAID:342633;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TISCH, ROLAND MICHAEL;",1863499;,5R01AI066075,03/01/2006,02/28/2011,"APC; Affect; Antigen-Presenting Cells; Apoptotic; Autoimmune Diabetes; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Autoregulation; B9 endocrine pancreas; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cells; Cells, CD4; Coupled; Data; Defect; Dendritic Cells; Development; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease Progression; Event; Gastrointestinal Tract, Pancreas; Genes; Goals; Homeostasis; Human; Human, General; Humulin R; IDD; IDDM; Immunologic Accessory Cells; Inbred NOD Mice; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Islands of Langerhans; Islet Cells; Islets of Langerhans; LYT3; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Inbred NOD; Mice, Transgenic; Molecular; Monocytes / Macrophages / APC; Mouse, NOD; Murine; Mus; Nesidioblasts; Non obese; Non-Obese Diabetic Mice; Nonobese; Nonobese Diabetic Mouse; Novolin R; PTK Receptors; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Peripheral; Phagocytosis; Physiological Homeostasis; Predisposition; Professional Role; RTK; Receptor Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Reporting; Reticuloendothelial System, Thymus; Role; Self Tolerance; Shapes; Susceptibility; T-Cell Receptor; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; T4 Cells; T4 Lymphocytes; Thymocyte Selection; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Transgenic Mice; Transmembrane Receptor Protein Tyrosine Kinase; Type 1 diabetes; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Veiled Cells; accessory cell; autoimmune disorder; base; beta cell development; cell type; diabetes; diabetic; endocrine pancreas; endocrine pancreas development; helper T cell; insulin dependent diabetes; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; macrophage; selective expression; selectively expressed; self recognition (immune); social role; thymocyte; thymus derived lymphocyte; type I diabetes; uptake",The Role of MerTK in Autoimmune Diabetes,,66075,ZRG1,Special Emphasis Panel,,5,342633,
7758236,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI066120-05,,NIAID:357172;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"WEISS, ARTHUR ;",1885600;,5R01AI066120,02/15/2006,01/31/2011,"APC; ATGN; ATP[{..}]protein-tyrosine O-phosphotransferase; Antigen Receptors; Antigen-Presenting Cells; Antigens; B blood cells; B-Cells; B-Lymphocytes; B220; Biochemical; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD148; CD45; Cell Communication and Signaling; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Cytoplasmic Receptors; Cytosolic Protein Tyrosine Phosphastase; DEP1; DNA Recombination; DNA recombination (naturally occurring); Defect; Dephosphorylation; Development; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Embryo; Embryonic; Endothelial Cells; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial Cells; Exons; Extracellular Matrix, Integrins; Fc Receptor; FcR; GP180; Gene Inactivation; Gene Silencing; Genes; Genetic Recombination; HEK3; HPTPeta; Hematopoietic; Heterophil Granulocyte; Immune response; Immunologic Accessory Cells; Immunologic, Immunochemical; Immunologics; Integrins; Intracellular Communication and Signaling; Jurkat Cells; LCA; LY5; Learning; Lecithinases; Lymphocyte; Lymphocytic; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Marrow Neutrophil; Mice; Monocytes / Macrophages / APC; Murine; Mus; Myelogenous; Myeloid; Myeloid Cell Activation; Myeloid Cells; Neutrophilic Granulocyte; Neutrophilic Leukocyte; PTK; PTK Receptors; PTPRC; PTPRC gene; PTPRJ; PTPRJ gene; PTPase; Pathway interactions; Phospholipase; Phosphorylation; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Protein Dephosphorylation; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Phosphatase; R-PTP-ETA; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Receptors, Antigen; Receptors, Antigen, T-Cell; Recombination; Recombination, Genetic; Reporting; Role; SCC1; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Superantigens; Synapses; Synaptic; T-Cell Receptor; T-Cells; T-Lymphocyte; T200; TM Domain; Thymus-Dependent Lymphocytes; Tissues; Transmembrane Domain; Transmembrane Receptor Protein Tyrosine Kinase; Transmembrane Region; Tumor Suppressor Proteins; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Phosphatase; Tyrosine Phosphorylation; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosyl Phosphoprotein Phosphatase; Tyrosylprotein Kinase; accessory cell; antibody receptor; base; biological signal transduction; cultured cell line; host response; hydroxyaryl protein kinase; immunogen; immunoresponse; lymph cell; neutrophil; pathway; protein tyrosine phosphate phosphohydrolase; receptor; receptor function; response; social role; thymus derived lymphocyte; tumor suppressor; tyrosyl protein kinase; vascular",Function of the RPTP CD148 in the Hematopoietic Lineage,,66120,CMIA,Cellular and Molecular Immunology - A Study Section,,5,357172,
7759643,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI066938-05,,NIAID:261599;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"RAMSINGH, ARLENE ;",1885917;,5R01AI066938,02/01/2006,01/31/2011,"AIDS Vaccines; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adjuvant; Affect; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Assay; B blood cells; B-Cell Epitopes; B-Cells; B-Lymphocyte Epitopes; B-Lymphocytes; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Capsid Proteins; Categories; Cell Culture Techniques; Cells; Cells, CD4; Clinical Trials, Phase I; Coat Proteins; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Coxsackie Viruses; Coxsackievirus; Data; Development; ELISA; ELISPOT; Early-Stage Clinical Trials; Editorial Comment; Editorial Comment (PT); Envelope Glycoprotein gp120, HIV; Enzyme-Linked Immunosorbent Assay; Epitopes; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Escape Mutant; Evaluation; Funding; Future; Gagging; Genes, Class I; Genes, Class II; Genes, HLA Class II; Genes, MHC Class I; Genes, MHC Class II; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Goals; Grant; HIV; HIV Envelope Protein gp120; HIV Infections; HIV vaccine; HIV-1; HIV-I; HIV/AIDS Vaccines; HIV1; HTLV-III; HTLV-III Infections; HTLV-III gp120; HTLV-III-LAV Infections; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immune; Immune response; Immunity; Immunodeficiency Virus Type 1, Human; Individual; Inducer Cells; Infection; Investigators; LAV-HTLV-III; Laboratories; Leader Peptide; Lymphadenopathy-Associated Virus; MHC Class I; MHC Class I Genes; MHC Class II; MHC Class II Genes; Macaca; Macaque; Mammals, Mice; Mice; Monitor; Murine; Mus; Mutation; Nasal; Nose; Nose, Nasal Passages; Oral; Ovalbumin; Pathway interactions; Peptide Leader Sequences; Peptides; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Polymorphism (Genetics); Polymorphism, Genetic; Polyproteins; Preventive; Process; Programs (PT); Programs [Publication Type]; Public Health; Published Comment; Recombinant Vaccines; Recombinants; Reflex, Pharyngeal; Research; Research Personnel; Researchers; Respiratory System, Nose, Nasal Passages; Route; Serum; Signal Peptide, Leader; Structure; Surface; T-Cell Epitopes; T-Cell Proliferation; T-Cells, Helper-Inducer; T-Lymphocyte Epitopes; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocytes; Testing; Toxic effect; Toxicities; Vaccine Research; Vaccines; Variant; Variation; Viewpoint; Viewpoint (PT); Viral Coat Proteins; Viral Outer Coat Protein; Viral Vector; Virus; Virus-HIV; Viruses, General; Work; antibody biosynthesis; base; cost; design; design and construction; designing; env Protein gp120, HIV; enzyme linked immunospot assay; experiment; experimental research; experimental study; fitness; genome mutation; gp120; gp120 ENV Glycoprotein; gp120(HIV); helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunogenic; immunogenicity; immunoglobulin biosynthesis; immunoresponse; innovate; innovation; innovative; neutralizing antibody; new approaches; new vaccines; next generation vaccines; novel; novel approaches; novel strategies; novel strategy; novel vaccines; pathway; phase 1 study; phase 1 trial; phase I trial; plasmid vaccine; polymorphism; programs; protocol, phase I; public health medicine (field); research study; response; vaccine candidate; vaccine development; vector; vector vaccine",HIV vaccine development using recombinant coxsackieviruses,,66938,VACC,HIV/AIDS Vaccines Study Section,,5,261599,
7759599,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI067020-04,,NIAID:459600;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,PATHOLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"PAUL, SUDHIR ;",1866941;,5R01AI067020,02/01/2007,01/31/2012,"AIDS; AIDS Virus; ATGN; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affinity; Amino Acids; Antibodies; Antigenic Determinants; Antigens; B blood cells; B cell receptor; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Biochemical; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Antigen (P55); CD4 Antigens; CD4 Molecule; CD4 Protein; Cell Communication and Signaling; Cell Signaling; Cleaved cell; Combining Site; Complex; Crystallographies; Crystallography; Dependence; Distant; Elements; Envelope Glycoprotein gp120, HIV; Epitopes; HIV; HIV Envelope Protein gp120; HTLV-III; HTLV-III gp120; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Hydrogen Oxide; IgA; Immunization; Immunoglobulin A; Immunologic Deficiency Syndrome, Acquired; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; In Vitro; Individual; Intracellular Communication and Signaling; LAV-HTLV-III; Length; Libraries; Link; Lupus; Lymphadenopathy-Associated Virus; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Membrane; Mice; Molecular Interaction; Murine; Mus; Mutagenesis, Site-Directed; OKT4 antigen; PBMC; Pathway interactions; Patients; Peptides; Peripheral Blood Mononuclear Cell; Phage Display; Preparation; Property; Property, LOINC Axis 2; Protein Cleavage; Proteolysis; Reaction; Reactive Site; Reagent; Receptors, Antigen, B-Cell; Receptors, CD4; Receptors, Surface CD4; Recruitment Activity; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specificity; Structure; Superantigens; T-Cell Antigen T4/Leu3; T-Cell Surface Antigen T4/Leu-3; T4 molecule; Targeted DNA Modification; Targeted Modification; Testing; Vaccination; Viral; Virion; Virus; Virus Particle; Virus-HIV; Viruses, General; Water; aminoacid; analog; base; biological signal transduction; cleaved; env Protein gp120, HIV; gp120; gp120 ENV Glycoprotein; gp120(HIV); helper T lymphocyte marker; immunogen; interest; membrane structure; monomer; novel; pathway; peptide analog; recruit; response; stem; synthetic peptide",Nucleophilic Antibodies: Characterization and Induction,,67020,AIP,AIDS Immunology and Pathogenesis Study Section,,4,459600,
7760128,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI067093-04,,NIAID:375123;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"KARN, JONATHAN ;",7580846;,5R01AI067093,02/01/2007,01/31/2012,"AIDS Virus; Ablation; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; BTF2 transcription factor; Basal Transcription Factor; Bioassay; Biochemical; Biologic Assays; Biological Assay; CHIP assay; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell model; CellLine; Cells; Cellular model; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Structure; Complex; Computer Systems Development; Consensus; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Development, Computer Systems; EC 2.7.7.6; Enhancers; Event; Feedback; Gene Transcription; General Transcription Factors; Generalized Growth; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genome; Goals; Growth; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Histone Acetylase; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immune response; Immunodeficiency Virus Type 1, Human; Immunoglobulin Enhancer-Binding Protein; Individual; Infection; Initiation Factors; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; LAV-HTLV-III; Lead; Lentiviral Vector; Lentivirus Vector; Lymphadenopathy-Associated Virus; Lytic; Microscopy; Molecular; Monitor; Mutation; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleus; Pathway interactions; Pb element; Peptide Initiation Factors; Play; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proviruses; RNA Expression; RNA Polymerases; RNA chemical synthesis; RNA synthesis; RNA, Viral; Recruitment Activity; Research; Research Personnel; Researchers; Resolution; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Systems Development; T-Cells; T-Lymphocyte; TFIIH; Testing; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Transcription; Transcription Factor NF-kB; Transcription Factors, General; Transcription Initiation; Transcription, Genetic; Translation Initiation Factor; Translational Initiation Factor; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus-HIV; Viruses, General; basic transcription factor 2; biological signal transduction; chromatin immunoprecipitation; cultured cell line; experiment; experimental research; experimental study; falls; genome mutation; heavy metal Pb; heavy metal lead; histone acetyltransferase; host response; human T cell leukemia virus III; human T lymphotropic virus III; immunoresponse; intervention development; kappa B Enhancer Binding Protein; latent infection; mutant; nuclear factor kappa beta; ontogeny; pathway; programs; recruit; research study; response; social role; therapy development; thymus derived lymphocyte; transcription factor; transcription factor IIH; transcription factor TFIIH; treatment development; viral RNA; virus RNA; virus protein",Molecular mechanisms regulating HIV entry and exit from latency,,67093,ZRG1,Special Emphasis Panel,,4,375123,
7752846,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI067359-05,,NIAID:430492;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"PAMER, ERIC G;",1892839;,5R01AI067359,02/01/2006,01/31/2011,"2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; ATGN; Address; Adoptive Transfer; Adrenal Cortex Hormones; Allergic; Allergic Bronchopulmonary Aspergillosis; Allergic asthma; Allo BMT; Allogeneic BMT; Allogeneic Bone Marrow Transplantation; Alveolar Macrophages; Antigens; Applications Grants; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Aspiration, Respiratory; Asthma; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; Bone Marrow Transplant; Bone Marrow Transplantation; Bone-Derived Transforming Growth Factor; Breathing; Bronchial Asthma; Bronchopulmonary Aspergillosis; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; CTX; CYCLO-cell; Carloxan; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cells, CD4; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; Complex; Corticoids; Corticosteroids; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytophosphan; Cytophosphane; Cytoxan; Disease; Disorder; Endoxan; Endoxana; Enduxan; Extrinsic asthma; Fosfaseron; Functional impairment; Fungal Spores; Fungi, Filamentous; Fungus Diseases; Generations; Genetic; Genoxal; Genuxal; Germination; Goals; Grafting, Bone Marrow; Grant Proposals; Grants, Applications; Hand; Heterophil Granulocyte; Human; Human, General; Hybridomas; IFN; IL-10; IL-13; IL-4; IL10; IL10A; IL13; IL4; IL4 Protein; Immune; Immune response; Immune system; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Receptors; Immunological Receptors; Immunosuppressed Host; Individual; Infection; Inflammatory; Inflammatory Response; Inhalation; Inhaling; Inspiration, Respiratory; Interferons; Interleukin 10 Precursor; Interleukin-10; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Intracellular Communication and Signaling; Killings; Label; Ledoxina; Life; Lung; Lung diseases; Lymphocyte Stimulatory Factor 1; MCGF-2; MHC Receptor; Macrophages, Alveolar; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow Transplantation; Mast Cell Growth Factor-2; Mediastinal; Mediating; Mice; Mice, Transgenic; Milk Growth Factor; Mitoxan; Molds; Mouse Strains; Murine; Mus; Mycoses; Neosar; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Oxidative Burst; Pathogenesis; Phenotype; Platelet Transforming Growth Factor; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Prevention; Process; Procytox; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Macrophages; Receptor Cell; Receptors, Antigen, T-Cell; Receptors, Immunologic; Reproduction spores; Respiratory Burst; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Sendoxan; Signal Transduction; Signal Transduction Systems; Signaling; Spores; Spores, Fungal; Syklofosfamid; T-Cell Growth Factor 2; T-Cell Proliferation; T-Cell Receptor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TGF B; TGF-beta; TGFbeta; Therapeutic Corticosteroid; Thymus-Dependent Lymphocytes; Tissues; Transforming Growth Factor beta; Transgenic Mice; Zytoxan; atopic asthma; base; biological signal transduction; body system, allergic/immunologic; combat; cultured cell line; disease/disorder; experiment; experimental research; experimental study; extrinsic allergic asthma; functional disability; fungal infection; fungus; fungus infection; helper T cell; host response; human disease; immune receptor; immunogen; immunoresponse; immunosuppressed patient; in vivo; insight; inspiration; leukocyte oxidative burst; lung disorder; neutrophil; novel therapeutic intervention; organ system, allergic/immunologic; pathogen; prevent; preventing; pulmonary; research study; respiratory burst (leukocyte); response; social role; thymus derived lymphocyte; trafficking",Characterization of Aspergillus fumigatus specific CD4 T cell responses.,,67359,ZRG1,Special Emphasis Panel,,5,430492,
7755840,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI067391-04,,NIAID:336518;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ROCHESTER,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"WARD, BRIAN M;",7123614;,5R01AI067391,02/15/2007,01/31/2012,"A33; Affect; Alanine; Alanine, L-Isomer; Animal Model; Animal Models and Related Studies; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Attenuated Vaccines; Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Capital; Cell Surface A33 Antigen; Cells; Charge; Chemistry, Biological; Co-Immunoprecipitations; Complex; Data; Defect; Discipline; Disease; Disorder; Drug Design; Energy Transfer; Event; Family; Fluorescence; GPA33; GPA33 gene; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetics-Mutagenesis; Glycoprotein A33; Goals; Golgi; Golgi Apparatus; Golgi Complex; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infection; Investigators; L-Alanine; Letters; Life; Location; Mammals, Mice; Maps; Membrane; Mice; Microscopy; Molecular; Molecular Biology, Mutagenesis; Molecular and Cellular Biology; Morphogenesis; Murine; Mus; Mutagenesis; Mutation; ORFs; Open Reading Frames; Orthopoxvirus; P. variolae; P.variolae; Phenotype; Play; Point Mutation; Position; Positioning Attribute; Poxviridae; Poxvirus officinale; Poxvirus variolae; Poxviruses; Process; Production; Programs (PT); Programs [Publication Type]; Protein Coding Region; Proteins; RNA Expression; Recombinant Vaccines; Recombinants; Relative; Relative (related person); Research Personnel; Researchers; Role; Sensitization, Immunologic; Sensitization, Immunological; Series; Site; Smallpox; Smallpox Vaccine; Smallpox Viruses; Staging; Structure; System; System, LOINC Axis 4; Systemic infection; Testing; Transcription; Transcription, Genetic; Vaccines; Vaccines, Attenuated; Vaccinia virus; Variola; Variola virus; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virion; Virulence; Virus; Virus Diseases; Virus Particle; Viruses, General; Work; base; cellular targeting; coat (enveloped virus); design; designing; disease/disorder; experiment; experimental research; experimental study; expression vector; gene product; genome mutation; in vivo; innovate; innovation; innovative; interest; live vaccine; member; membrane structure; model organism; mutant; neutralizing antibody; novel; pox virus; programs; protein function; protein protein interaction; recombinant vaccinia virus; recombinant virus; research study; small pox; small pox vaccine; small pox virus; social role; trafficking; variola major; vector; viral infection; virus envelope; virus infection; virus protein; ward; weapons",Protein Interactions Involved in Orthopoxvirus Envelopment,,67391,VIRA,Virology - A Study Section,,4,336518,
7758334,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI067405-04,,NIAID:310587;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HANOVER,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"BERWIN, BRENT L.;",8192098;,5R01AI067405,03/15/2007,02/29/2012,"55-kDa High-Affinity Calcium Binding Protein; A Mouse; APC; ATGN; Adjuvant; Antigen Presentation; Antigen Presentation Pathway; Antigen Processing and Presentation; Antigen-Presenting Cells; Antigens; CAB-63; CBP3 (Liver); CD8; CD8B; CD8B1; CD8B1 gene; Calcium-Binding Protein-3; Calregulin; Cell Maturation; Cell secretion; Cell surface; Cells; Cellular Secretion; Chaperone; Characteristics; Class II Antigens; Class II Major Histocompatibility Antigens; Clinical; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Complex; Cross Presentation; Cytokine Activation; Dendritic Cells; Development; ERp60; Ectopic Expression; Endocytosis; Endoplasmic Reticulum; Endotoxins; Ergastoplasm; GRP94; Genetic; Goals; HACBP; Histocompatibility; Histocompatibility Antigens Class II; Human; Human, General; I-A Antigen; ITX; Ia Antigens; Ia-Like Antigens; Immune Response Antigens; Immune response; Immune system; Immune-Response-Associated Antigens; Immunity; Immunologic Accessory Cells; Immunologic Techniques; Immunological Technics; Immunological Techniques; Immunologically Directed Therapy; Immunotherapy; Investigators; Kidney Cancer; Kidney Carcinoma; LYT3; Lead; Ligands; MHC Class II Molecule; MHC Class II Protein; MHC class II antigen; Major Histocompatibility Complex Class II; Malignant Melanoma; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Mice; Molecular; Molecular Chaperones; Monocytes / Macrophages / APC; Murine; Mus; Neoplasm Metastasis; Pathway interactions; Pb element; Peptides; Phase; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Receptor Protein; Renal Cancer; Renal carcinoma; Research; Research Personnel; Researchers; Role; SR-A proteins; Secondary Neoplasm; Secondary Tumor; System; System, LOINC Axis 4; T memory cell; T-Cell Activation; T-Cells; T-Lymphocyte; Technics, Immunologic; Techniques; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissue Compatibility; Tumor Cell Migration; Tumor Immunity; Veiled Cells; accessory cell; acetylated LDL receptor; base; body system, allergic/immunologic; cC1qR Protein; calreticulin; cancer metastasis; cancer progression; clinical investigation; clinical test; defined contribution; gene product; heavy metal Pb; heavy metal lead; host response; immune therapy; immunogen; immunogenic; immunogenicity; immunoresponse; improved; in vivo; insight; macrophage; melanoma; member; memory T lymphocyte; neoplasm progression; neoplastic progression; novel; organ system, allergic/immunologic; pathway; programs; receptor; receptor function; receptor, acetyl-LDL; research clinical testing; response; scavenger receptor; scavenger receptors, class A; social role; thymus derived lymphocyte; trafficking; tumor; tumor progression; uptake; vaccination strategy",Mechanisms of Chaperone-Mediated Immune Responses,,67405,CMIB,Cellular and Molecular Immunology - B Study Section,,4,310587,
7754700,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI067460-05,,NIAID:446760;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"MOWEN, KERRI A;",3125017;,5R01AI067460,02/01/2006,01/31/2011,"Allergic; Amino Acid Sequence; Amino Acids; Antibodies; Arginine; Arginine deiminase; Arginine, L-Isomer; Assay; Atrophic Arthritis; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binding; Binding (Molecular Function); Binetrakin; Bioassay; Biologic Assays; Biological Assay; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Citrulline; Closure by Ligation; Cytokine Gene; Data; Ectopic Expression; Event; Exons; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes, Reporter; Gln; Glutamine; Histones; Human; Human, General; Hydrolysis; IL-4; IL4; IL4 Protein; Immune; Immune response; Immunologic Receptors; Immunological Receptors; In Vitro; Inflammatory; Inflammatory Arthritis; Interleukin-4; Interleukin-4 Precursor; Investigators; L-Arginine; L-Glutamine; L-Ornithine, N5-(aminocarbonyl)-; Ligation; Link; Lymphocyte; Lymphocyte Stimulatory Factor 1; Lymphocytic; MCGF-2; MGC[{..}]45012; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mast Cell Growth Factor-2; Mediating; Methylation; Mice; Modification; Molecular; Molecular Interaction; Mono-S; MonoS; Murine; Mus; Mutate; Nuclear Protein; Nuclear Proteins; Pattern; Phenotype; Photometry/Spectrum Analysis, Mass; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Predisposition; Production; Programs (PT); Programs [Publication Type]; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Structure, Primary; Protein-arginine deiminase; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Q. Levoglutamide; Receptor Signaling; Receptors, Antigen, T-Cell; Receptors, Immunologic; Regulation; Regulatory Protein; Reporter Genes; Research Personnel; Researchers; Rheumatoid Arthritis; Role; Signal Pathway; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; Susceptibility; T-Cell Growth Factor 2; T-Cell Receptor; T-Cells; T-Lymphocyte; TRAF2; TRAF2 gene; TRAP3; Targetings, Gene; Testing; Th-2 Cell; Th2 Cells; Thymus-Dependent Lymphocytes; Type 2 Helper Cell; aminoacid; arginine converting enzyme; arginine dihydrolase; arginine iminohydrolase; arginine methyltransferase; autoimmune disorder; base; cell type; cofactor; cytokine; gene product; genetic regulatory protein; host response; immune receptor; immunoresponse; in vivo; lymph cell; methyl group; mutant; novel; overexpression; peptidylarginine deiminase; prevent; preventing; programs; protein sequence; protein-L-arginine iminohydrolase; regulatory gene product; response; self recognition (immune); social role; thymus derived lymphocyte; tool",Cytokine Gene Regulation by Modification of Arginine Residues,,67460,CMI,Cellular and Molecular Immunology - A,,5,446760,
7763198,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI067698-05,,NIAID:343026;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,VETERINARY SCIENCES,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"CHRISTENSEN, BRUCE MARTIN;",8064273;,5R01AI067698,02/15/2006,01/31/2011,"21+ years old; Adult; Aedes; Aedes (genus); Anopheles; Anopheles Genus; Anti-Bacterial Agents; Anti-Bacterial Response; Antibacterial Agents; Antibacterial Response; Assay; Bacteria; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biology; Blood Plasma; Blood granulocytic cell; Candidate Disease Gene; Candidate Gene; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cellular Immunity; Competence; Complex; Culex; Culex (Genus); Culex pipiens; Culex pipiens mosquito; Culicidae; Cytolysis; Data; Data Set; Dataset; Defensins; Dose; Drosophila; Drosophila genus; E coli; ESTs; Escherichia coli; Evaluation; Event; Expressed Sequence Tags; Female; Fruit Fly, Drosophila; Gene Action Regulation; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Grant; Granular Leukocytes; Granulocytic cell; Hemocytes; Hemolymph; Human, Adult; Humoral Immunities; Immune; Immune response; Immunities, Humoral; Immunity; Immunity, Cellular; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Individual; Infection; Injection of therapeutic agent; Injections; Insecta; Insects; Invaded; Invertebrates, Insects; K. pneumoniae; Killings; Klebsiella pneumonia bacterium; Klebsiella pneumoniae; Knowledge; Lysis; Method LOINC Axis 6; Methodology; Microarray Analysis; Microarray-Based Analysis; Microbe; Micrococcus luteus; Molecular; Mortality; Mortality Vital Statistics; Mosquitoes; Natural Immunity; Oligo; Oligonucleotides; Pathogenicity; Pathology; Pattern; Peptides; Phagocytosis; Phagolysosome; Phenotype; Plasma; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Preparation; Process; Production; Proteins; Protocol; Protocols documentation; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Reaction; Research; Research Design; Reticuloendothelial System, Serum, Plasma; Role; S. aureus; S. typhimurium; S.aureus; S.typhimurium; Saline; Saline Solution; Salmonella typhimurium; Sequence-Specific Posttranscriptional Gene Silencing; Serum, Plasma; Signal Pathway; Staphylococcus aureus; Staphylococcus epidermidis; Study Type; Testing; Time; Transcription; Transcription, Genetic; Variant; Variation; Wound Healing; Wound Repair; adult human (21+); anti-bacterial; antibacterial; antibody-based immunity; antimicrobial peptide; base; cDNA Library; cellular pathology; experiment; experimental research; experimental study; fruit fly; gene expression signature; gene product; granulocyte; holistic approach; host response; immunoresponse; insight; microarray technology; microbial; pathogen; pathogenic bacteria; research study; response; social role; study design; synthetic peptide; tissue repair; tool; transcriptome; vector; vector mosquito; web site",Hemocyte Transcriptome and Immunity in Aedes aegypti,,67698,ZRG1,Special Emphasis Panel,,5,343026,
7766299,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI067712-05,,NIAID:238469;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,BIOCHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"THERIOT, JULIE A.;",1863189;,5R01AI067712,02/01/2006,01/31/2011,"Actins; Affect; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antimicrobial Cationic Peptides; Automation; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial Infections; Bacterial resistant; Behavior; Biochemical; Biological; Categories; Cell Lineage; Cell division; Cell membrane; Cells; Cellular biology; Chimera Protein; Chimeric Proteins; Chromosomes; Clinical; Coliform Bacilli; Communities; Complex; Computer Programs; Computer software; Cytoplasmic Membrane; Data; Diffuse; Disease; Disorder; Drug Exposure; Drug Resistance, Multiple; Drug Resistant, Multiple; EPEC; Enteral; Enteric; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Environment; Exposure to; Filament; Fusion Protein; GFP; Genes; Goals; Gram-Negative Bacteria; Green Fluorescent Proteins; Image; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; Individual; Infection; Investigators; LPS; Label; Learning; Life; Lipopolysaccharides; Measures; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods and Techniques; Methods, Other; Microbicidal Cationic Proteins; Microscopy, Video; Miscellaneous Antibiotic; Modeling; Motion; Movement; Multi-Drug Resistance; Multidrug Resistance; Osmolar Concentration; Osmolarity; Pathogenesis; Pathogenicity Factors; Pattern; Periplasmic Space; Phenotype; Plasma Membrane; Plasmids; Programs (PT); Programs [Publication Type]; Protein Dynamics; Protein Export; Protein Export Pathway; Proteins; Pump; ROC Analysis; Receptor Cell; Regulation; Research; Research Personnel; Research Resources; Researchers; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Resolution; Resources; Role; S. enterica; S. flexneri; Salmonella; Salmonella enterica; Shigella flexneri; Shigella flexneri bacterium; Software; Stimulus; Surface; Surface Proteins; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Temperature; Testing; Therapeutic; Time; Track and Field; Variant; Variation; Video Microscopy; Videomicrography; Videomicroscopy; Virulence Factors; Work; Yersinia; antimicrobial peptide; bacterial disease; bacterial resistance; base; body movement; cell biology; cell envelope; cell imaging; cellular imaging; computational tools; computer program/software; computerized tools; disease/disorder; efflux pump; enteric pathogen; enteropathogenic E. coli; enteropathogenic E.coli; enteropathogenic Escherichia coli; experience; experiment; experimental research; experimental study; gene product; image evaluation; imaging; macrophage; membrane structure; multi-drug resistant; multidrug resistant; novel; open source; overexpression; overgrowth bacterial; particle; pathogen; periplasm; periplasmic; plasmalemma; programs; protein distribution; research study; resistance to Bacteria; resistance to Bacterial; resistant; resistant to Bacteria; resistant to Bacterial; response; social role",Surface protein dynamics in live bacterial pathogens,,67712,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,5,238469,
7755405,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI067752-04,,NIAID:337610;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"FIRESTEIN, GARY STEVEN;",1868524;,5R01AI067752,02/01/2007,01/31/2012,"5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1[{..}]1); Agonist; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Arthritis; Articulation; Atrophic Arthritis; Body Tissues; CCL5; CRG-2; CXCL10; CXCL10 gene; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cell-Extracellular Matrix; Cells; Chemokine (C-C Motif) Ligand 5; Closure by Ligation; Collagen Arthritis; Collagen-Induced Arthritis; Collection; Complex; Cytokine Receptors; Cytokines, Chemotactic; D17S136E; DNA Binding; DNA Binding Interaction; Data; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; ECM; EFF; Extracellular Matrix; FLJ11330; Fibroblasts; Gamma interferon; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Homologous Chemotactic Cytokines; Host Defense; Human; Human, General; IFI10; IFN; IFN-Gamma; IFN-g; IFNG; INFLM; INP10; IP-10; Immune; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; Inflammation; Inflammatory; Inflammatory Arthritis; Inflammatory Response; Intercrines; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interferons; Intracellular Communication and Signaling; Investigators; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Joints; K/BxN model; Kinases; Ligands; Ligation; Link; Location; MGC17164; MMPs; MOB-1; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediating; Membrana Synovialis Capsulae Articularis; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Modeling; Murine; Mus; NAK; NF-KB-Activating Kinase; NF-KB-Activating Kinase NAK; NF-Kb-Activating Kinase Gene; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Necrosis; Necrotic; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nuclear Translocation; Pathogenesis; Pathway interactions; Pattern; Phosphorylation; Phosphotransferases; Play; Poly I-C; Poly(I).poly(C); Poly(rI).Poly(rC); Polyinosinic acid[{..}]polycytidylic acid; Polyinosinic-Polycytidylic Acid; Polyribose Inosin-Cytidil; Production; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; RANTES; RANTES Protein, T-Cell; RNA Expression; RNA, Small Interfering; Receptors, Cytokine; Regulation; Relative; Relative (related person); Replacement Therapy; Research Personnel; Researchers; Rheumatoid Arthritis; Role; SCYA5; SCYB10; SIS cytokines; SIS delta; SIS-delta; SISd; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Small Inducible Cytokine A5; Small Interfering RNA; Structure; Synovial Membrane; Synovitis; Synovium; T-Cell Specific Protein p288; T2K; TANK Binding Kinase TBK1; TANK-binding kinase 1; TBK1; TBK1 gene; TCP228; TLR protein; TLR3; TLR3 gene; Tissues; Toll-like receptors; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Transphosphorylases; arthritic; base; biological signal transduction; c jun; c-jun Gene; chemoattractant cytokine; chemokine; cytokine; disease/disorder; effusion; experiment; experimental research; experimental study; functional status; gIP-10; gene product; host response; immunoresponse; insight; joint destruction; kappa B Enhancer Binding Protein; lFN-Gamma; metalloproteinase (general); model organism; new therapeutic target; nuclear factor kappa beta; pathway; poly IC; polyinosate.polycytidylate; programs; research study; response; siRNA; social role; transcription factor",Innate immunity and the IKKi complex in Rheumatoid Arthritis (RA) synovium,,67752,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,4,337610,
7763212,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI067839-02,,NIAID:303930;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"WANG, QINGHUA ;",8262634;,5R01AI067839,02/03/2009,01/31/2013,"Address; Adverse effects; Affect; Affinity; Amino Acid Substitution; Antibodies; Antigenic Determinants; Aves; Avian; B Virus; B virus infection; Behavior; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Biochemical; Birds; Care, Health; Categories; Cell Surface Glycoproteins; Cell Surface Receptors; Cells; Cercopithecid herpesvirus 1; Cercopithecine Herpesvirus 1; Combining Site; Complex; Development; Distant; Ensure; Epitopes; Face; Foundations; Future; Genetic Alteration; Genetic Change; Genetic defect; Glycoproteins; Grippe; Healthcare; Hemagglutinin; Herpes Virus B; Herpes simiae; Herpes simiae infection; Herpesvirus 1 (alpha), Cercopithecine; Herpesvirus 1, Cercopithecine; Herpesvirus B; Herpesvirus B infection; Herpesvirus simiae; Hong Kong; Hongkong; Human; Human, General; Infection; Influenza; Influenza A virus; Influenza B virus; Influenza HA; Influenza Hemagglutinin; Influenza Virus; Influenza Viruses Type A; Influenza Viruses Type B; Knowledge; L-Tyrosine; Location; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Glycoproteins; Molecular; Molecular Interaction; Monkey B Virus; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutation; N-Acetylneuraminic Acids; NIAID; National Institute of Allergy and Infectious Disease; Orthomyxovirus Type A; Orthomyxoviruses Type B; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Qualifying; Reactive Site; Receptor Protein; Receptors, Cell Surface; Science of Virology; Severities; Sialic Acids; Simian B disease; Simian B disorder; Simian B virus infection; Simian Herpesvirus; Site; Solid; Structure; Surface Glycoproteins; TYR; Treatment Side Effects; Tyrosine; Tyrosine, L-isomer; Variant; Variation; Viral; Virology; Virus; Viruses, General; analog; base; combat; design; designing; driving force; facial; flu infection; genome mutation; improved; influenza infection; influenzavirus; influenzavirus (unspecified); membrane structure; mutant; neutralizing mAb; neutralizing monoclonal antibodies; new approaches; novel approaches; novel strategies; novel strategy; para-Tyrosine; pathogen; pressure; public health relevance; receptor; receptor binding; side effect; success; therapy adverse effect; treatment adverse effect; virology; weapons",Structural and Functional Study of Influenza Virus Hemagglutinin," PROJECT NARRATIVE  Influenza virus is among the National Institute of Allergy and Infectious Diseases Category C priority pathogens. Infection caused by influenza B virus remains a serious threat to global healthcare. The proposed studies aim to substantially improve the fundamental understanding of influenza B virus as an important human pathogen, may help future development of novel strategies for combating morbidity and mortality caused by influenza B virus infection, and provide a strong driving force to the influenza B virology field.",67839,VIRA,Virology - A Study Section,,2,303930,
7760585,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI067858-05,,NIAID:356079;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STILLWATER,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,049987720,US,OK,74078,OKLAHOMA STATE UNIVERSITY STILLWATER,"PICKING, WENDY L;",8250676;,5R01AI067858,02/15/2007,01/31/2012,"ATGN; Antigens; Arts; Bacillary Dysentery; Biochemical; C-terminal; Cell membrane; Cells; Complex; Computer Simulation; Computerized Models; Coupled; Cytoplasm; Cytoplasmic Membrane; DISSEC; Data; Deletion Mutagenesis; Development; Dissection; Distal; Docking; Drugs; Dysentery; Dysentery, Bacillary; Electron Microscopy; Fluorescence Spectroscopy; Foundations; Genetics-Mutagenesis; Gram-Negative Bacteria; Image; Imaging Procedures; Imaging Techniques; In Vitro; Infection; Infectious Diarrheal Disease; Invaded; Investigation; Investigators; Knowledge; Lead; Mammalian Cell; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Membrane; Methods; Methods and Techniques; Methods, Other; Microscopic; Microscopy; Models, Computer; Molecular; Molecular Biology, Mutagenesis; Movement; Mutagenesis; N-terminal; NH2-terminal; NMR Spectroscopy; Needles; Pathogenesis; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma Membrane; Plasmids; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Proteins; Recruitment Activity; Relative; Relative (related person); Research Personnel; Researchers; Role; S. flexneri; Shapes; Shigella; Shigella Dysentery; Shigella Infections; Shigella flexneri; Shigella flexneri bacterium; Simulation, Computer based; Spectroscopy, Fluorescence; Spectroscopy, NMR; Stimulus; Structure; Surface; Syringes; Technics, Imaging; Techniques; Testing; Type III Secretion System; Type III Secretion System Pathway; Vaccines; Virulence; basal body; base; body movement; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; drug/agent; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; imaging; immunogen; in silico; in vivo; kinetosome; knowledge base; membrane structure; mutant; new vaccines; next generation vaccines; novel vaccines; nuclear magnetic resonance spectroscopy; plasmalemma; prevent; preventing; programs; protein protein interaction; reconstruction; recruit; research study; shigellosis; simulation; social role; virtual simulation",Control of Type III secretion in Shigella by lpaD,,67858,BACP,Bacterial Pathogenesis Study Section,,5,356079,
7777840,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI067869-04,,NIAID:507596;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LEXINGTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"STRALEY, SUSAN C;",1868225;,5R01AI067869,03/16/2007,02/29/2012,"Biology; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; CD8; CD8B; CD8B1; CD8B1 gene; CTL; Cell Communication and Signaling; Cell Signaling; Cell-Mediated Lympholytic Cells; Cells; Cytokine Signal Transduction; Cytokine Signaling; Cytokines, Chemotactic; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; Data; Dendritic Cells; Down-Regulation; Down-Regulation (Physiology); Downregulation; Edodekin Alfa; Effector Cell; Exposure to; Foundations; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Human; Human, General; IFN-gamma-Inducing Factor; IGIF; IL-1; IL-1 Gamma; IL-12; IL-15; IL-18; IL-1g; IL1; IL12; IL15; IL15 Protein; IL18 Protein; IL1F4; Immune; Immune response; Infection; Intercrines; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin I; Interleukin-1; Interleukin-1 Gamma; Interleukin-12; Interleukin-15; Interleukin-15 Precursor; Interleukin-18; Interleukin-18 Precursor; Intracellular Communication and Signaling; K lymphocyte; Knockout Mice; LYT3; Lung; Lymphocyte-Stimulating Hormone; MGC12320; MGC9721; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Marrow Neutrophil; Mediating; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; NK Cells; NKSF; Natural Killer Cell Stimulatory Factor; Natural Killer Cells; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Parents; Pasteurella pestis; Pathway interactions; Plague; Pneumonic Plague; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Predictive Value; RNA, Messenger; Reporting; Resistance; Respiratory System, Lung; Reticuloendothelial System, Spleen; SIS cytokines; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spleen; T Helper Factor; T-Cells; T-Lymphocyte; T-Lymphocytes, Cytotoxic; Testing; Therapeutic Intervention; Thymus-Dependent Lymphocytes; Time; Toxin; Veiled Cells; Virulence; Virulent; Y. pestis; Y.pestis; Yersinia pestis; Yersinia pestis disease; biological signal transduction; cDNA Arrays; cDNA Microarray; chemoattractant cytokine; chemokine; cytokine; experiment; experimental research; experimental study; host response; immunoresponse; insight; intervention therapy; lymphocyte activating factor; mRNA; mRNA Expression; macrophage; microbial host; mouse model; mutant; neutrophil; pathogen; pathway; prevent; preventing; pulmonary; research study; resistant; thymus derived lymphocyte",YopM and protective innate defenses against plague,,67869,HIBP,Host Interactions with Bacterial Pathogens Study Section,,4,507596,
7760920,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI067949-05,,NIAID:424165;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"IZARD, TINA ;",2305485;,5R01AI067949,02/01/2006,01/31/2011,"Actin Filaments; Actinin; Actins; Address; Adherens Junction; Adhering Junction; Adhesion Plaques; Adhesions; Adhesive Junction; Affect; Affinity; Anchoring Junction; Animal Model; Animal Models and Related Studies; Assay; Bacillary Dysentery; Bacteria; Band 2 Protein; Barbed End of the Actin Filament; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Terrorism; Bioterrorism; C-terminal; Calorimetry; Cell Communication and Signaling; Cell Junctions; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Matrix Adherens Junctions; Cells; Cellular Matrix; Cellular Migration; Coin; Combining Site; Complex; Cytoskeletal Proteins; Cytoskeletal System; Cytoskeleton; Data Set; Dataset; Developing Countries; Developing Nations; Disease; Disorder; Dysentery, Bacillary; Economics; Esteroproteases; Extracellular Matrix, Integrins; F-Actin; Filamentous Actin; Focal Adhesions; Focal Contacts; Foundations; Genes; Goals; Health; Human; Human, General; Hydrophobic Interactions; Integrins; Interactions, Hydrophobic; Intercellular Junctions; Intracellular Communication and Signaling; Investigators; Lead; Length; Less-Developed Countries; Less-Developed Nations; Man (Taxonomy); Man, Modern; Mediating; Microfilaments; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Movement; Myofilaments; Pathogenesis; Pb element; Peptidases; Peptide Hydrolases; Physiologic; Physiological; Play; Plus End of the Actin Filament; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Reactive Site; Receptor Protein; Regulation; Research Personnel; Researchers; Resolution; Rest; Role; S. flexneri; Salmonella; Shigella; Shigella Dysentery; Shigella Infections; Shigella flexneri; Shigella flexneri bacterium; Shigella ipaB protein; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Tail; Talin; Testing; Third-World Countries; Third-World Nations; Translating; Translatings; Under-Developed Countries; Under-Developed Nations; VCL; Vinculin; Vinculin (Caenorhabditis elegans clone pRB9.1 protein moiety reduced); Work; biological signal transduction; body movement; cell motility; combat; conformation; conformational state; depolymerization; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; intracellular skeleton; ipaB protein, Shigella; language translation; migration; model organism; mutant; novel; pathogen; paxillin; polymerization; programs; protein structure; receptor; reconstitute; reconstitution; research study; shigellosis; social role; uptake",Pathogen-host Interactions that Remodel the Cytoskeleton,,67949,MSFB,Macromolecular Structure and Function B Study Section,,5,424165,
7772256,R01,AI,5,,03/01/2010,02/28/2011,PA-04-119,5R01AI068002-04,,NIAID:358864;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,073271827,US,NY,10065,NEW YORK BLOOD CENTER,"JIANG, SHIBO ;",2103422;,5R01AI068002,03/15/2007,02/28/2011,"21+ years old; Abscission; Adjuvant; Adult; Adverse effects; Alanine; Alanine, L-Isomer; Alum Adjuvant; Animals; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; BALB/c; Binding; Binding (Molecular Function); Binding Determinants; Biological; Biological Terrorism; Biosynthetic Proteins; Bioterrorism; Blood Serum; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Calorimetry; Canada; Cells; Cells, CD4; Chimera Protein; Chimeric Proteins; China; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Civet Cats; Civets; Cleaved cell; Clinic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Codon; Codon Nucleotides; Collaborations; Coronavirus; Coronavirus (genus); Cysteine; Cytofluorometry, Flow; Development; Disease Outbreaks; Dose; E coli; ELISA; Enzyme-Linked Immunosorbent Assay; Enzymes; Epidemic; Epitopes; Escherichia coli; Esteroproteases; Excision; Exhibits; Extirpation; Ferrets; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fusion Protein; Future; Genes; Goals; HPLC; Half-Cystine; Health; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; High Pressure Liquid Chromatography; Human; Human, Adult; Human, General; Immune response; Immunity; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inbred BALB C Mice; Inducer Cells; Infection; Infection prevention; Inflammatory; Injection of therapeutic agent; Injections; Intramuscular; Investigators; L-Alanine; L-Cysteine; Laboratories; Length; Liver; Lung; MF59; Mainland China; Mammals, Mice; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mice; Mice, Inbred BALB C; Microbiology; Microfluorometry, Flow; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mouse, BALB C; Murine; Mus; Organ; Oryctolagus cuniculus; Outbreaks; Patients; Peptidases; Peptide Hydrolases; Phase; Populations at Risk; Preparedness; Prevent infection; Production; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Rabbit, Domestic; Rabbits; Reaction; Readiness; Recombinant Proteins; Recombinants; Regimen; Removal; Reporting; Research Personnel; Researchers; Respiratory System, Lung; Route; SARS; Safety; Science of Microbiology; Sensitization, Immunologic; Sensitization, Immunological; Serum; Severe Acute Respiratory Syndrome; Solubility; Structure; Subunit Vaccines; Surgical Removal; System; System, LOINC Axis 4; T-Cells, Helper-Inducer; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Testing; Titrations; Treatment Side Effects; Vaccines; Vaccines, Subunit; Vaccinia Vaccine; Viral; Virus Replication; Viverridae; Yeasts; adult human (21+); aged; alum; aluminum sulfate; antibody biosynthesis; base; biodefense; body system, hepatic; cleaved; clinical investigation; conformation; conformational state; disulfide bond; expression vector; flow cytophotometry; gene product; helper T cell; host response; immunoglobulin biosynthesis; immunoresponse; improved; in vivo; neutralizing antibody; organ system, hepatic; pathogen; pre-clinical; preclinical; prevent; preventing; programs; protein expression; pulmonary; receptor binding; resection; response; side effect; subcutaneous; therapy adverse effect; treatment adverse effect; vaccine candidate; vaccine efficacy; vector; virus multiplication",SARS-CoV S Protein Receptor-binding Domain-based Vaccines,,68002,VMD,Vaccines Against Microbial Diseases Study Section,,4,358864,
7759552,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI068003-05,,NIAID:517585;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"COMPANS, RICHARD W;",1875490;,5R01AI068003,02/15/2006,01/31/2011,"1-Aminoadamantane; APC; ATGN; Acylneuraminyl hydrolase; Adamantylamine; Address; Amantadine; Antibodies; Antigen Targeting; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Antiviral Agents; Antiviral Drugs; Antivirals; Asia, Southeastern; Assay; Aves; Avian; Avian Influenza A Virus; B blood cells; B-Cells; B-Lymphocytes; Baculovirus Expression System; Baculoviruses; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Biological Models; Birds; Blood Plasma Cell; Body Tissues; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTL assay; Cell surface; Cells; Cells, CD4; Chickens; Core Protein; Country; ELISPOT; Ensure; Enzymes; Epitopes; Event; Exhibits; Flu epidemic; Flu vaccine; Formalin; Fowl Plague Virus; GM-CSF; GMCSF; Galactosidase; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Glycoproteins; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Grippe; H1N1 Virus; H5 hemagglutinin; H5N1; H5N1 virus; Hemagglutination; Hemagglutinin; Hemagglutinins, Viral; Histamine-Producing Cell-Stimulating Factor; Home; Home environment; Human; Human, General; Immune response; Immunity; Immunization; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infection; Influenza; Influenza A Virus, Avian; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Influenza HA; Influenza Hemagglutinin; Influenza Vaccines; Influenza Virus; Influenza Virus, Avian; Influenza virus vaccine; Institute of Medicine; Institute of Medicine (U.S.); Investigators; Label; Langerhans cell; Life; Ligands; Lung; Lymphoid; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane; Memory; Memory B Cell; Memory B-Lymphocyte; Metabolic Glycosylation; Methods; Mice; Mice, Transgenic; Model System; Modeling; Models, Biologic; Molecular Interaction; Molgramostin; Monitor; Monocytes / Macrophages / APC; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Myxovirus pestis galli; N-Acylneuraminate Glycohydrolases; NAS/IOM; Neuraminidase; Oligosaccharide Sialidase; Organ; Orthomyxovirus Type A, Avian; Peptides; Phenotype; Plasma Cells; Plasmacytes; Population; Preparedness; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Readiness; Recombinants; Recurrence; Recurrent; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Rimantadine; Sensitization, Immunologic; Sensitization, Immunological; Serotyping; Sialidase; Source; Southeast Asia; Southeastern Asia; Staining method; Stainings; Stains; Surface; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TC-GM-CSF; Testing; Thymus-Dependent Lymphocytes; Tissues; Transgenic Mice; Tricyclo(3.3.1.13,7)decan-1-amine; Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-; Tumor-Cell Human GM Colony-Stimulating Factor; Vaccination; Vaccine Production; Vaccines; Viral; Viral Diseases; Viral Hemagglutinins; Virus; Virus Diseases; Virus-like particle; Viruses, General; accessory cell; aquatic bird; avian flu virus; base; bird flu virus; cell mediated immune response; cost; cytokine; design; designing; efficacy testing; egg; enzyme linked immunospot assay; exo alpha sialidase; experience; expression vector; flu infection; gene product; glycosylation; granulocyte macrophage colony stimulating factor; helper T cell; host response; immunogen; immunogenic; immunogenicity; immunoresponse; in vivo; influenza epidemic; influenza infection; influenzavirus; influenzavirus (unspecified); macrophage; membrane structure; mouse model; neutralizing antibody; new vaccines; next generation vaccines; novel; novel vaccines; novel virus; pandemic; pandemic disease; pandemic flu; pandemic influenza; plasmocyte; programs; protective efficacy; pulmonary; resistant; response; thymus derived lymphocyte; vaccine candidate; vaccine efficacy; viral infection; virus infection; viruslike particle",Novel VLP vaccines for pandemic influenza virus,,68003,ZRG1,Special Emphasis Panel,,5,517585,
7761757,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068058-04,,NIAID:410329;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"TARAKHOVSKY, ALEXANDER ;",6819669;,5R01AI068058,02/01/2007,01/31/2012,"Actins; Address; Antigen Receptors; Biochemical; Cancer Treatment; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromatin; Complex; Cytosol; Development; Drosophila melanogaster; EC 2.1.1; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Genetic; Genetics-Mutagenesis; Histones; Immune Cell Activation; Immunity; Immunomodulation; Intracellular Communication and Signaling; Investigators; L-Lysine; Ligands; Lymphocyte Function; Lysine; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Maps; Mediating; Methods; Methylation; Methyltransferase; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Nucleus; Pattern; Peripheral; Physiologic; Physiological; Play; Programs (PT); Programs [Publication Type]; Protein Family; Protein Methylases; Protein Methylation; Protein Methyltransferases; Proteins; Public Health; Receptor Protein; Receptors, Antigen; Receptors, Antigen, T-Cell; Regulation; Research Personnel; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Subcellular Process; T-Cell Activation; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; Testing; Thymus-Dependent Lymphocytes; Transducers; anticancer therapy; biological signal transduction; cancer therapy; cell type; computerized data processing; data processing; experiment; experimental research; experimental study; gene function; gene product; histone H3 methyltransferase; histone methylase; histone methyltransferase; immune modulation; immunologic reactivity control; immunoregulation; in vivo; methylase; mouse development; novel; polymerization; programs; protein function; public health medicine (field); receptor; research study; response; signal processing; social role; thymus derived lymphocyte; transcription factor; transmethylase",Control of T cell signaling by methyltransferase Ezh2,,68058,ZRG1,Special Emphasis Panel,,4,410329,
7759222,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068062-05,,NIAID:305795;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,PEDIATRICS,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HUTTENLOCHER, ANNA ;",1885022;,5R01AI068062,02/15/2006,01/31/2011,"Affinity; Allergic; Amino Acids; Antimorphic mutation; Arthritis; Atrophic Arthritis; Attenuated; Autoimmune Status; Autoimmunity; BPTP3; Bacterial Infections; Basophilic Granulocyte; Basophilic Histiocyte; Basophilic Leukocyte; Basophils; Basophils, Tissue; Biochemical; Blood (Leukemia); Blood Basophil; CD 23 Antigens; CD23 Antigens; CFC; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell Surface Receptors; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Exhibits; Family; Family member; Fc Receptor; FcR; Genes; Genetic; Goals; HC phosphatase; Hcph gene product; HePTP; Host Defense; Human; Human, General; IP3-5-phosphatase; IgE; IgE Receptors; IgG Receptors; Immune response; Immune system; Immunoglobulin E; Immunoglobulin E Receptor; Immunoglobulin G Receptor; In Vitro; Individual; Inflammatory Arthritis; Ins(1,4,5)P3 5'-phosphatase; Intracellular Communication and Signaling; K/BxN model; L-Tyrosine; Leukemias, General; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Basophil; Marrow Mast Cell; Mediating; Mice; Molecular; Multiple Sclerosis; Murine; Mus; NS1; PTP-1D; PTP2C; PTPN11; PTPN11 gene; Parasitic infection; Pathogenesis; Pathway interactions; Patients; Prevention; Process; Receptor Protein; Receptors, Cell Surface; Receptors, IgE; Receptors, IgG; Regulation; Rheumatoid Arthritis; Role; SH-PTP1; SH-PTP2; SH-PTP3; SHP PTPase; SHP-1; SHP-1 phosphatase; SHP-1 tyrosine phosphatase; SHP-2; SHP1 gene product, phosphatase; SHP1 phosphatase; SHP1 protein tyrosine phosphatase; SHP2; SHPTP1; Sclerosis, Disseminated; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; Surface; TYR; Testing; Therapeutic Intervention; Time; Tyrosine; Tyrosine, L-isomer; allergic response; aminoacid; antibody receptor; arthritic; attenuation; bacterial disease; base; biological signal transduction; body system, allergic/immunologic; disease/disorder; epsilon Fc Receptors; experiment; experimental research; experimental study; gamma Fc Receptors; haematopoietic cell phosphatase; hematopoietic cell-specific tyrosine phosphatase SHP-1; host response; human disease; human hematopoietic tyrosine phosphatase; immunoresponse; in vivo; inositol 5-phosphatase; inositol polyphosphate 5-phosphatase; inositol triphosphatase; inositol triphosphate 5-phosphatase; inositol-1,4,5-trisphosphate 5-phosphatase; insight; insular sclerosis; intervention therapy; leukemia; mast cell; mastocyte; member; mouse model; myoinositol trisphosphatase; novel; organ system, allergic/immunologic; para-Tyrosine; pathway; protein-tyrosine phosphatase SHP; receptor; research study; response; self recognition (immune); social role; therapeutic development; treatment strategy",Regulation of Mast Cell Function by Inhibitory Molecules,,68062,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,305795,
7768426,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI068090-05,,NIAID:364245;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"BARON, JODY L;",1934358;,5R01AI068090,03/01/2006,02/28/2011,"APC; Acute; Antigen-Presenting Cells; Antigens, Viral; Assay; B virus infection; Bioassay; Biologic Assays; Biological Assay; Carcinoma of the Liver Cells; Cells; Chronic; Chronic Hepatitis; Chronic Hepatitis B; Chronic Phase; Cirrhosis; Cytotoxic cell; Dendritic Cells; Disease; Disease Outcome; Disease model; Disorder; HBV; HBV Chronic Infection; HCC; Hepadnaviridae; Hepadnavirus; Hepadnaviruses; Hepatic; Hepatic Disorder; Hepatitis; Hepatitis B Virus; Hepatitis B, Chronic; Hepatitis Virus, Homologous Serum; Hepatitis, Chronic; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Herpes simiae infection; Herpesvirus B infection; Human; Human, General; Hybridomas; ITX; Immune; Immune response; Immune system; Immunologic Accessory Cells; Immunologically Directed Therapy; Immunotherapy; In Vitro; Infection; Injury; K lymphocyte; Ligands; Liver; Liver diseases; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Modeling; Monocytes / Macrophages / APC; Murine; Mus; NK Cells; Natural Killer Cells; Pathogenesis; Pathologic; Pathology; Primary carcinoma of the liver cells; Process; Resolution; Role; Simian B disease; Simian B disorder; Simian B virus infection; System; System, LOINC Axis 4; Testing; Transgenic Animals; Transgenic Mice; Veiled Cells; Viral; Viral Antigens; Viral Diseases; Virus; Virus Diseases; Virus Replication; Viruses, General; accessory cell; body system, allergic/immunologic; body system, hepatic; cytokine; design; designing; disease/disorder; disorder model; hepatopathy; host response; immune therapy; immunoresponse; in vitro Model; in vivo; killer T cell; liver disorder; model design; mouse model; organ system, allergic/immunologic; organ system, hepatic; pathogen; prevent; preventing; response; social role; viral infection; virus antigen; virus infection; virus multiplication",Understanding Immunopathogenesis of Hepatitis B Virus,,68090,ZRG1,Special Emphasis Panel,,5,364245,
7754879,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068129-10,,NIAID:350878;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LANIER, LEWIS L;",1945373;,5R01AI068129,01/09/2001,01/31/2011,"Address; Area; B blood cells; B-Cells; B-Lymphocytes; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD161; CD94 Antigen; CMV; Cell Communication and Signaling; Cell Signaling; Cells; Cellular biology; Cytomegalovirus; Cytotoxic cell; Data; Dendritic Cells; Goals; HCMV; Human; Human, General; Immunity; In Vitro; Intracellular Communication and Signaling; K lymphocyte; KLRB1; KLRB1 gene; KLRD1 Protein; Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Gene; Killer Cell Lectin-Like Receptor Subfamily D, Member 1; Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2; Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein; Kp43 antigen; Ligands; Ly-49P receptor; Ly49P receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Murine; Mus; NK Cell Receptor; NK Cells; NKR-P1; NKR-P1A; NKRP1A; Natural Killer Cells; Natural Killer Cells Antigen CD94; Receptor Protein; Resistance; Role; Salivary Gland Viruses; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Time; Tumor Cell; Veiled Cells; Viral; Virus; Viruses, General; base; biological signal transduction; cell biology; cytomegalovirus group; expression cloning; hNKR-P1A; human cytomegalovirus; neoplastic cell; pathogen; receptor; resistant; social role",NK Cell Receptors and Their Ligands,,68129,ZRG1,Special Emphasis Panel,,10,350878,
7761197,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068137-04,,NIAID:625228;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,002604817,US,PA,19104,DREXEL UNIVERSITY,"BERGMAN, LAWRENCE W.;",1862040;,5R01AI068137,02/15/2007,01/31/2012,"ATPase, Actin-Activated; Actin-Binding Protein; Actins; Address; Adenosine Triphosphatase, Myosin; Aldehyde-Lyases; Aldolases; Bio-Informatics; Bioinformatics; Biological Function; Biological Process; Biology; Blood; Blood erythrocyte; Blood normocyte; Blood reticulocyte; Cell surface; Cells; Complex; Culicidae; Cytoplasmic Domain; Cytoplasmic Tail; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Diffusely basophilic erythrocyte; Enzymes; Epithelium; Erythrocytes; Erythrocytic; Event; Gene Deletion; Generalized Growth; Genetic; Genome; Growth; Head and Neck, Salivary Glands; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human, General; Immunologic, Immunochemical; Immunologics; Insecta; Insects; Integral Membrane Protein; Intervention; Intervention Strategies; Intrinsic Membrane Protein; Invaded; Invertebrates, Insects; Investigators; Lead; Life Cycle; Life Cycle Stages; Ligands; Link; Liver; Liver Cells; MIC2 adhesive protein, Toxoplasma gondii; MIC2 protein, Toxoplasma gondii; Malaria; Mammalian Cell; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Marrow reticulocyte; Membrane; Midgut; Modeling; Molecular; Mosquitoes; Motor; Myosin A; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosin IIA; Myosin Type IIA, Non-Muscle; Myosins; Nature; Nonmuscle Myosin Type IIA; Paludism; Parasites; Pathway interactions; Pb element; Peptides; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Play; Polychromatophilic Erythrocyte; Process; Property; Property, LOINC Axis 2; Protein Binding; Proteins; Reagent; Receptor Protein; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Personnel; Researchers; Reticulocytes; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Rodent; Rodentia; Rodentias; Role; Salivary Glands; Specificity; Sporozoites; Staging; Structure; Tail; Temperature; Terminology; TgMIC2 protein, Toxoplasma gondii; Tissue Growth; Toxoplasma gondii MIC2 protein; Transmembrane Protein; Two Hybrid; Uncertainty; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; base; blood corpuscles; body system, hepatic; cDNA Library; cell type; circumsporozoite; circumsporozoite protein; clinical data repository; clinical data warehouse; cs protein; data repository; doubt; gene deletion mutation; gene product; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; interest; interventional strategy; life course; membrane structure; myosin ATP phosphohydrolase (actin translocating); ontogeny; organ system, hepatic; pathway; protein protein interaction; receptor; relational database; small molecule; small molecule libraries; social role; yeast two hybrid system",Plasmodium Invasion Machinery,,68137,ZRG1,Special Emphasis Panel,,4,625228,
7769503,R01,AI,5,,03/01/2010,02/28/2011,,5R01AI068390-04,,NIAID:360555;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MAYWOOD,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,04,791277940,US,IL,60153,LOYOLA UNIVERSITY CHICAGO,"KNIGHT, KATHERINE L;",1874665;,5R01AI068390,03/01/2007,02/29/2012,"21+ years old; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Adoptive Transfer; Adult; Age; Age-Months; Aged 65 and Over; Antibodies; Autoimmune Diseases; Autoregulation; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; BUdR; Birth; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Culture Techniques; Cell Lineage; Cell-Extracellular Matrix; Cells; Data; Dose; ECM; Elderly; Elderly, over 65; Elements; Extracellular Matrix; Extracellular Matrix Proteins; Face; GALT; Generations; Goals; Grant; Gut associated lymphoid tissue; Homeostasis; Human; Human, Adult; Human, General; IL-7; IL7 Protein; Immune response; Immune system; Immunity; In Vitro; Infection; Interleukin 7 Precursor; Interleukin-7; Investigators; Lead; Left; Life; Lymphatic Tissue; Lymphocyte; Lymphocytic; Lymphoid Tissue; Lymphopoiesis; Lymphopoietin-1; Maintenance; Maintenances; Mammals, Mice; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mice; Microorganisms, General; Modeling; Murine; Mus; Oryctolagus cuniculus; Parturition; Pb element; Peripheral; Physiological Homeostasis; Plant Embryos; Population; Process; Production; RNA Splicing; Rabbit, Domestic; Rabbits; Radiation; Receptor Protein; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Seeds; Solutions; Splicing; Staging; Stromal Cells; Testing; Therapeutic Intervention; Time; Uridine, 5-bromo-2'-deoxy-; Vaccination; Variant; Variation; Work; Zygotes, Plant; adult human (21+); advanced age; aged; autoimmune disorder; body system, allergic/immunologic; bone; elders; experiment; experimental research; experimental study; facial; geriatric; heavy metal Pb; heavy metal lead; host response; immunoresponse; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; irradiation; late life; later life; lymph cell; lymphocytopoiesis; microorganism; mid life; mid-life; middle age; middle aged; midlife; notch; notch protein; notch receptors; older adult; older person; organ system, allergic/immunologic; periostin; progenitor; ray (radiation); receptor; research study; seed; senior citizen",Maintaining B cell immunity with aged B lymphocytes,,68390,CMAD,Cellular Mechanisms in Aging and Development Study Section,,4,360555,
7758356,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068493-06,,NIAID:287623;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBUS,UNITED STATES,VETERINARY SCIENCES,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"WU, LI ;",8314827;,5R01AI068493,02/15/2006,01/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; B blood cells; B-Cells; B-Lymphocytes; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-Type Lectins; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD50 Antigen; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Cessation of life; Chemicals; Co-culture; Cocultivation; Coculture; Coculture Techniques; Communicable Diseases; Death; Dendritic Cells; Development; Experimental Designs; Goals; HIV; HIV vaccine; HIV-1; HIV-I; HIV/AIDS Vaccines; HIV1; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; ICAM-3; Immune response; Immunodeficiency Virus Type 1, Human; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intercellular Adhesion Molecule 3; Intracellular Communication and Signaling; LAV-HTLV-III; Lectins, C-Type; Lymphadenopathy-Associated Virus; Lymphocyte antigen CD50; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Molecular; Mucosa; Mucosal Tissue; Mucous Membrane; Myelogenous; Myeloid; Pathogenesis; Physiologic pulse; Play; Process; Protein, nef; Proteins; Pulse; Regulation; Relative; Relative (related person); Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Transmission; Veiled Cells; Viral; Viral Diseases; Viral Pathogenesis; Virus Diseases; Virus-HIV; base; biological signal transduction; cell type; combat; cytokine; design; designing; effective intervention; gene product; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunoresponse; nef Protein; novel; particle; social role; thymus derived lymphocyte; trafficking; transmission process; viral infection; virus infection; virus pathogenesis",Mechanisms Underlying Dendritic Cell-mediated HIV Transmission,,68493,AMCB,AIDS Molecular and Cellular Biology Study Section,,6,287623,
7759190,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068497-05,,NIAID:377311;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"FEENEY, MARGARET E;",6765410;,5R01AI068497,02/15/2007,01/31/2012,"0-11 years old; 21+ years old; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Adult; Alleles; Allelomorphs; Antigenic Determinants; Antiviral Therapy; Attenuated; Binding Determinants; CD8; CD8B; CD8B1; CD8B1 gene; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Child; Child Youth; Childhood; Children (0-21); Collaborations; Containment; Cytofluorometry, Flow; Data; Disease; Disease Progression; Disorder; Enrollment; Epitopes; Event; Evolution; Exhibits; FLR; Failure (biologic function); Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frequencies (time pattern); Frequency; Genetic Alteration; Genetic Change; Genetic defect; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Immune; Immune response; Immunologic Deficiency Syndrome, Acquired; In Vitro; Individual; Infant; Infection; Infection specific to the perinatal period; Investigation; Investigators; Jamaica; LAV-HTLV-III; LYT3; Life; Light; Lymphadenopathy-Associated Virus; Mediating; Methods; Microfluorometry, Flow; Modeling; Mothers; Mutation; Perinatal; Perinatal Infection; Phase; Phenotype; Photoradiation; Play; Population; Programs (PT); Programs [Publication Type]; Prospective Studies; Research Personnel; Researchers; Role; SEQ-AN; Sampling; Sepsis - perinatal; Sequence Analyses; Sequence Analysis; Specificity; Staging; Subcellular Process; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; Thymus-Dependent Lymphocytes; Transmission; Vaccine Design; Vaccines; Variant; Variation; Vertical Disease Transmission; Vertical Transmission; Viral; Viral Burden; Viral Load; Viral Load result; Viremia; Virus; Virus-HIV; Viruses, General; adult human (21+); base; children; disease/disorder; enroll; failure; fitness; flow cytophotometry; genome mutation; host response; immunoresponse; in vivo; infancy; infantile; mother to child transmission; pediatric; pediatric human immunodeficiency virus infection; programs; response; social role; thymus derived lymphocyte; transmission process; treatment of viral infectious disease; viraemia; viral sepsis; virusemia; youngster",The impact of CD8 T cells on viral control and evolution in HIV-infected infants,,68497,AIP,AIDS Immunology and Pathogenesis Study Section,,5,377311,
7759136,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068731-05,,NIAID:431435;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,076647908,US,WA,981012795,BENAROYA RESEARCH INST AT VIRGINIA MASON,"ZIEGLER, STEVEN F;",1861825;,5R01AI068731,02/01/2006,01/31/2011,"A-152E5.3; ABCD-1 protein; ABCD-2; ATGN; Acidophilic Leukocyte; Address; Alleles; Allelomorphs; Allergens; Allergic; Allergic asthma; Allergic inflammation; Animal Model; Animal Models and Related Studies; Antibodies; Antigens; Asthma; Atopic Allergy; Atopic Dermatitis; Attenuated; B Cell Differentiation Factor I; B blood cells; B cell activating factor; B cell growth factor; B cell growth factor 2; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Growth Factor-II; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Biological Models; Blood Eosinophil; Body Tissues; Bronchial Asthma; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CCL17; CCL17 gene; CCL22 chemokine; CD11c; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cells; Cells, CD4; Data; Dendritic Cells; Dermatitis, Atopic; Development; Disease; Disease Progression; Disorder; Dysfunction; EDF; Eczema, Atopic; Eo-CSF; Eosinophil Differentiation Factor; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Epithelial; Epithelial Cells; Epithelium; Event; Exhibits; Extrinsic asthma; Family; Fibrosis; Functional disorder; Goals; Goblet Cells; Grant; HTRPY; Human; Human, General; Hyperplasia; Hyperplastic; Hypertrophy; IL-13; IL-4; IL-5; IL13; IL4; IL4 Protein; IL5; INFLM; ITGAX; ITGAX gene; IgA enhancing factor; IgE; Immunoglobulin E; Individual; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Interleukin-5; Intracellular Communication and Signaling; Investigators; Leg; Little's Disease; Lung; Lymphocyte; Lymphocyte Function; Lymphocyte Stimulatory Factor 1; Lymphocytic; Lymphoid Cell; MCGF-2; MDC (chemokine); Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Mast Cell Growth Factor-2; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Transgenic; Mind; Model System; Modeling; Models, Biologic; Mucous body substance; Mucus; Murine; Mus; Myelogenous; Myeloid; Nature; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; Pathogenesis; Pathology; Patients; Phenotype; Physiopathology; Play; Population; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Pulmonary Surfactant Protein C; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactant-Associated Protein SP-C; Receptor Protein; Reporter; Research Personnel; Researchers; Respiratory System, Lung; Rhinitis; Role; SCYA17; SP-C peptide; SP-C protein; STAT6 Transcription Factor; STCP-1; Series; Signal Transducer and Activator of Transcription 6; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Source; Spastic Diplegia; Spastic Diplegias; Stat6 protein; Stimulated T Cell Chemotactic Protein 1; Surfactant Polypeptide SP-C; T cell replacing factor; T-Cell Growth Factor 2; T-Cell Replacing Factor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TARC; TSLP; TSLP cytokine; TSLP protein, human; Testing; Thymic Stromal Lymphopoietin; Thymic Stromal Lymphopoietin Protein TSLP; Thymus-Dependent Lymphocytes; Tissues; Transgenes; Transgenic Mice; Treatment Efficacy; Triad; Triad Acrylic Resin; Triad resin; Veiled Cells; airway epithelium infalmmation; airway inflammation; allergic dermatitis; allergic eczema; atopic asthma; atopy; base; biological signal transduction; cerebral spastic infantile paralysis; cytokine; design; designing; disease/disorder; eosinocyte; eosinophil; experiment; experimental research; experimental study; extrinsic allergic asthma; helper T cell; human TSLP protein; immunogen; lymph cell; macrophage; macrophage-derived chemokine; model organism; mouse model; mucous; pathophysiology; programs; pulmonary; receptor; research study; response; social role; therapeutic efficacy; therapeutically effective; thymus derived lymphocyte",TSLP and the Pathophysiology of Asthma,,68731,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,431435,
7756591,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068908-04,,NIAID:322314;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATHENS,UNITED STATES,NONE,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"KISSINGER, JESSICA C;",1928989;,5R01AI068908,02/01/2007,01/31/2011,"0-11 years old; Address; Affect; Algae; Algae, Red; Amaze; Animals; Apicomplexa; Bacteria; Behavior; Bio-Informatics; Bioinformatics; Biology; C. parvum; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Children (0-21); Chimp; Chimpanzee; Classification; Communities; Complex; Conflict; Conflict (Psychology); Cryptosporidium; Cryptosporidium parvum; DNA; DNA Recombination; DNA Sequence Rearrangement; DNA recombination (naturally occurring); Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Deposit; Deposition; Disease; Disorder; Distant; Drug resistance; ESTs; Elements; Event; Evolution; Expressed Sequence Tags; Gene Combinations; Gene Family; Gene Proteins; Gene Transfer; General Practitioners; Generalists; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Elements, Mobile; Genetic Materials; Genetic Recombination; Genetic defect; Genome; Genomics; History; Human; Human, Child; Human, General; Immune; In element; Indium; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Light; Location; METBL; Malaria; Man (Taxonomy); Man, Modern; Maps; Materials, Genetic; Metabolic; Metabolic Processes; Metabolism; Methods; Minor; Mobile Genetic Elements; Molecular; Mutation; Noise; Organelles; Organism; Ortholog; Orthologous Gene; Paludism; Pan; Pan Genus; Pan Species; Parasites; Pathway interactions; Pattern; Peptide Domain; Photoradiation; Phylogenetic Analysis; Phylogenetics; Phylogeny; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Domains; Protein Gene Products; Publications; Rearrangement; Recombination; Recombination, Genetic; Recording of previous events; Red Algae; Relative; Relative (related person); Repetitive Element; Repetitive Regions; Repetitive Sequence; Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Rest; Rhodophyta; Ribosomal RNA; Role; Scientific Publication; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Symbiosis; Syntenic Homology; Synteny; Systematics; T. gondii; Taxon; Tertiary Protein Structure; Testing; Therapeutic; Toxoplasma; Toxoplasma gondii; Vertebrate Animals; Vertebrates; base; biological signal transduction; children; clinical data repository; clinical data warehouse; commensalism; data repository; disease/disorder; drug resistant; genome mutation; genome sequencing; innovate; innovation; innovative; insight; living system; man; man's; member; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; paralog; paralogous gene; pathogen; pathway; programs; rRNA; relational database; resistance to Drug; resistant to Drug; social role; therapeutic target; transfer of a gene; vertebrata; youngster","Genome Evolution, Innovation and Adaptation in the Apicomplexa",,68908,PTHE,Pathogenic Eukaryotes Study Section,,4,322314,
7758187,R01,AI,5,,02/10/2010,01/31/2011,,5R01AI068943-04,,NIAID:325592;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,BIOLOGY,18,036837920,US,TX,772045037,UNIVERSITY OF HOUSTON,"YEO, HYEJEONG ;",8479829;,5R01AI068943,02/01/2007,01/31/2012,"Acute; Adherence; Adherence (attribute); Adhesins, Bacterial; Adhesives; Antibody Formation; Antibody Production; Antibody Response; Bacterial Adhesins; Biochemical; Blood Serum; C-terminal; Cell surface; Clinical; Communicable Diseases; Crystallization; Development; EC 2.4; Epithelial Cells; Epithelium, Respiratory; Genes; Glycoside Transferases; Goals; Grippe; H. influenza; H. influenza virulence; H. influenzae; H.influenza; H.influenza virulence; H.influenzae; HMW1 adhesin; Haemophilus influenza virulence; Haemophilus influenzae; Hemophilus; Human; Human, General; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Influenza; Investigators; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic Glycosylation; Molecular Weight; New Agents; Otitis Media; Pathogenesis; Pathogenicity Factors; Pathway interactions; Pilum; Play; Programs (PT); Programs [Publication Type]; Protein Family; Proteins; Research Personnel; Researchers; Respiratory Tract Diseases; Role; Serum; Structure; Structure of respiratory epithelium; Surface; Surface Proteins; System; System, LOINC Axis 4; Variant; Variation; Virulence Factors; adhesin; antibody biosynthesis; base; design; designing; fimbriae; flu infection; gene product; glycosylation; glycosyltransferase; hmw1A gene product; immunoglobulin biosynthesis; influenza infection; insight; membrane structure; novel; pathogen; pathogenic bacteria; pathway; pilus; polypeptide; programs; protein structure; social role",Structural Studies on Bacterial Two-Partner Secretion Systems,,68943,MSFB,Macromolecular Structure and Function B Study Section,,4,325592,
7762179,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068965-05,,NIAID:338453;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GAINESVILLE,UNITED STATES,PATHOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"MOREL, LAURENCE ;",1948815;,5R01AI068965,02/15/2006,01/31/2011,"Affect; Alleles; Allelomorphs; Antigens, Nuclear; Autoimmune; Autoimmune Diseases; Autoimmune Process; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; Backcrossings; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Candidate Disease Gene; Candidate Gene; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromosome Mapping; Congenic Strain; DISSEC; Disease; Disorder; Dissection; Gene Expression Profile; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Polymorphism; Genetics, Gene Mapping; Goals; Greater sac of peritoneum; Link; Linkage Analysis; Linkage Mapping; Location; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lupus Glomerulonephritis; Lupus Nephritis; Mammals, Mice; Maps; Mediating; Mice; Modeling; Monitor; Murine; Mus; Nuclear Antigens; Pathogenesis; Pathology; Penetrance; Peritoneal Cavity; Phenotype; Play; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Process; QTL; Quantitative Trait Loci; Racial Segregation; Recombinants; Relative; Relative (related person); Resolution; Role; SLE; SLE - Lupus Erythematosus, Systemic; SLEB1 gene; SLEB2 gene; Severities; Subcellular Process; Susceptibility; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Time; Transgenic Model; autoimmune disorder; base; congenic; disease/disorder; disseminated lupus erythematosus; family based linkage study; gene expression signature; genetic linkage analyses; genetic linkage analysis; genetic mapping; linkage analyses; polymorphism; segregation; sle1/sle3 gene; social role; systemic lupus erythematosis; systemic lupus erythematosus susceptibility 1; systemic lupus erythematosus susceptibility 2; transcriptome",Genetic dissection of Sle2 contribution to SLE pathogenesis,,68965,ZRG1,Special Emphasis Panel,,5,338453,
7754644,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI068977-06,,NIAID:375081;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GHOSH, SANKAR ;",1881933;,5R01AI068977,02/01/2006,01/31/2011,"AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; ATP-protein phosphotransferase; Activator Protein-1; Adhesiveness; Adhesives; Affect; Agreement; Biochemical; Biological; C-terminal; CD18; Cell Communication and Signaling; Cell Signaling; Cell-Death Protease; Cells; Co-Stimulator; Complex; Costimulator; EC 2.7; Enhancer-Binding Protein AP1; Epidermal Thymocyte Activating Factor; Esteroproteases; Event; Genetic Models; Goals; I kappa B kinase; I-kappa B; I-kappa B Proteins; ICE-like protease; IKB; IL-2; IL2; IL2 Protein; ITGB2; ITGB2 gene; IkappaB kinase; Immune response; Immunoglobulin Enhancer-Binding Protein; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Kinases; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knowledge; LAD; LCAMB; Lead; Link; Lipid Rafts, Cell Membrane; Lymphocyte Mitogenic Factor; MF17; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Maps; Mediating; Membrane; Membrane Microdomains; Mice; Mitogenic Factor; Models, Genetic; Molecular; Murine; Mus; NF-Kappa B Inhibitor; NF-kB; NF-kappa B; NF-kappaB; NFKB; NFKB Inhibitor; NFKBI; NK-kappa B-activating kinase NAK; Natural immunosuppression; Network Analysis; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Pathway Analysis; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Peptides; Phosphotransferases; Play; Production; Property; Property, LOINC Axis 2; Proteases; Protein Kinase; Proteinases; Proteins; Proteolytic Enzymes; Receptor Signaling; Receptors, Antigen, T-Cell; Recruitment Activity; Reporting; Role; Scaffolding Protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; T cell growth factor; T-Cell Activation; T-Cell Growth Factor; T-Cell Proliferation; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; Tail; Testing; Th-2 Cell; Th2 Cells; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Time; Transcription Factor AP-1; Transcription Factor NF-kB; Transgenic Organisms; Transphosphorylases; Type 2 Helper Cell; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Work; biological signal transduction; caspase; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; gene product; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; host response; hydroxyalkyl protein kinase; immunological synapse; immunoresponse; immunosuppression; intermolecular interaction; kappa B Enhancer Binding Protein; lipid raft; membrane structure; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; nuclear factor kappa beta; pathway; phosphoinositide-dependent kinase 1; phosphorylase b kinase kinase; recruit; social role; thymus derived lymphocyte; transcription factor; transgenic; ubiquination; ubiquitin conjugation",Mechanism of T Cell Receptor Mediated Activation of NFkappaB,,68977,CMIA,Cellular and Molecular Immunology - A Study Section,,6,375081,
7763187,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069000-05,,NIAID:293517;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"SARNOW, PETER ;",1865286;,5R01AI069000,02/15/2006,01/31/2011,"1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; 4-Thiouridine; Affect; Alferon; Amino Acid Transport Systems, Basic; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Assay; Basic Amino Acid Transport Proteins; Basic Amino Acid Transport Systems; Binding Sites; Bio-Informatics; Bioassay; Biochemical; Bioinformatics; Biologic Assays; Biological Assay; Biotinylation; Cationic Amino Acid Transport Proteins; Cationic Amino Acid Transport Systems; Cationic Amino Acid Transporters; Cells; Chronic; Cleaved cell; Collaborations; Combining Site; Common Rat Strains; Complementary DNA; Complex; Cultured Cells; DNA, Complementary; Data; Detection; Down-Regulation; Down-Regulation (Physiology); Downregulation; Elements; Eukaryote; Eukaryotic Cell; G-interferon; Gene Expression; Gene Products, RNA; Genes; Genetics-Mutagenesis; Ginterferon; Grafting, Liver; HCV; HCV Vaccine; Healed; Health; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatitis C virus; Hepatitus C; Hepatocyte; IFN Alpha; IFNa; IRES; Individual; Infection; Interferon Alfa-n3; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; Investigators; Label; Lead; Life Cycle; Life Cycle Stages; Liver; Liver Cells; Liver Transplant; Liver diseases; Mammals, Rats; Maps; Mediating; Micro RNA; MicroRNAs; Molecular Biology, Mutagenesis; Monitor; Mutagenesis; Nucleotides; Outcome Study; Pathogenesis; Pathway interactions; Patients; Pb element; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Quelling; RISC Multicomponent Nuclease; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA Stability; RNA amplification; RNA, Non-Polyadenylated; RNA, Small Interfering; RNA, Viral; RNA-Induced Silencing Complex; RNAi; RTCA; Rat; Rattus; Reactive Site; Reagent; Recombinant adeno-associated virus; Recombinant adeno-associated virus (rAAV); Recruitment Activity; Research Personnel; Researchers; Ribavirin; Ribonucleic Acid; Ribosome Entry Site; Ribovirin; Risk; Role; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Strepavidin; Streptavidin; Structure; Study, Outcome; System; System, LOINC Axis 4; Testing; Thiouridine; Translations; Transplantation of liver; Transplantation, Hepatic; Tribavirin; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urd; Uridine; Uridine, 4-thio-; Viral; Viral Genome; Virion; Virus; Virus Particle; Virus Replication; Viruses, General; body system, hepatic; cDNA; cellular targeting; cleaved; effective therapy; eukaryotida; gene product; healing; heavy metal Pb; heavy metal lead; hepatopathy; knock-down; life course; liver disorder; liver function; liver transplantation; miRNA; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; nuclease; organ system, hepatic; pathway; programs; reconstitute; reconstitution; recruit; siRNA; social role; stem; tool; treatment of viral infectious disease; viral RNA; virus RNA; virus multiplication",Roles for microRNA-122 in hepatitis C virus RNA amplification,,69000,VIRA,Virology - A Study Section,,5,293517,
7758222,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069007-05,,NIAID:358586;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"DOVE, SIMON L;",7603074;,5R01AI069007,02/01/2006,01/31/2011,"Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bacteria; CF patients; Communities; Cystic Fibrosis; Gene Cluster; Gene Expression; Gene Targeting; Generalized Growth; Genes; Gram-Negative Bacteria; Growth; Human; Human, General; Immune response; Light; Lung; Man (Taxonomy); Man, Modern; Microbial Biofilms; Miscellaneous Antibiotic; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucoviscidosis; Organism; P. aeruginosa; P.aeruginosa; Pathogenicity Factors; Phase; Photoradiation; Play; Process; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Repression; Resistance; Respiratory System, Lung; Role; Structure; Surface; Targetings, Gene; Testing; Tissue Growth; Virulence; Virulence Factors; base; biofilm; cystic fibrosis patients; gene product; host response; immunoresponse; living system; ontogeny; pathogen; patients with CF; patients with cystic fibrosis; pulmonary; resistant; rho; social role; termination factor; transcription termination",Phase-variable gene expression in Pseudomonas aeruginosa,,69007,BACP,Bacterial Pathogenesis Study Section,,5,358586,
7761272,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069087-04,,NIAID:344481;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LITTLE ROCK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"SMELTZER, MARK S;",1892863;,5R01AI069087,02/01/2007,01/31/2012,"2,6 dimethoxyphenylpenicillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-; Address; Amputation; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotic Therapy; Antibiotic Treatment; Antibiotic susceptibility; Antibiotics; Area; Articulation; Bacteria; Belief; Biocompatible Materials; Biomaterials; Blood flow; Bone; Bone Infection; Bone and Bones; Bones and Bone Tissue; Chronic; Clinical; Clinical Management; D-Glucose; Data; Detection; Development; Devices; Dextrose; Diagnosis; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Early Diagnosis; FLR; Failure (biologic function); Generalized Growth; Genus staphylococcus; Glucose; Glycans; Goals; Grant; Growth; Host Defense; INFLM; Implant; Infection; Inflammation; Investigators; Joints; Killings; Laboratories; Lactams; Lead; Mammals, Rabbits; Medical Imaging, Positron Emission Tomography; Methicillin; Methods; Microbial Biofilms; Miscellaneous Antibiotic; Modeling; Monitor; Musculoskeletal; NIH; National Institutes of Health; National Institutes of Health (U.S.); Necrosis; Necrotic; Operation; Operative Procedures; Operative Surgical Procedures; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Oryctolagus cuniculus; Osteomyelitis; PET; PET Scan; PET imaging; PETSCAN; PETT; Patient Care; Patient Care Delivery; Patients; Pb element; Penicillin, Dimethoxyphenyl; Phenotype; Polysaccharides; Positron Emission Tomography Scan; Positron-Emission Tomography; Prevalence; Proton Magnetic Resonance Spectroscopic Imaging; Rabbit, Domestic; Rabbits; Rad.-PET; Recommendation; Recurrence; Recurrent; Research; Research Personnel; Researchers; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resolution; S. aureus; S.aureus; Sampling; Site; Specificity; Staging; Staphylococcus; Staphylococcus aureus; Surgical; Surgical Interventions; Surgical Procedure; Testing; Therapeutic; Therapeutic Agents; Tissue Growth; Toxic effect; Toxicities; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Work; anti-microbial; anti-microbial agent; anti-microbial drug; antibiotic resistant; antimicrobial; antimicrobial agent; antimicrobial drug; base; bench bed side; bench bedside; bench to bed side; bench to bedside; biofilm; biomedical implant; bone; data acquisition; early detection; experiment; experimental research; experimental study; failure; heavy metal Pb; heavy metal lead; implant device; implantable device; indwelling device; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; pathogen; rapid diagnosis; rapid method; rapid technique; research study; resistant; resistant strain; response; surgery; translation research enterprise; treatment of bacterial diseases; treatment of bacterial infectious disease","Detection, diagnosis and treatment of musculoskeletal infection",,69087,ZRG1,Special Emphasis Panel,,4,344481,
7759108,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069142-04,,NIAID:329962;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GALVESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"SUN, JIAREN ;",6989600;,5R01AI069142,02/01/2007,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Address; Adenoviridae; Adenoviruses; Adopted; Alferon; American; Animal Model; Animal Models and Related Studies; Animals; Anti-Viral Response; Antigen Presentation; Antigenic Determinants; Antigens, Viral; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Area; Assay; B Cell-Associated Molecule CD40; Binding Determinants; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Circulation; Bloodstream; Blotting, Western; Bone Marrow; Bp50; Breeding; CD40; CD40 Antigens; CD40 Type II Isoform; CD40 molecule; CD40L Receptor; CDW40; CDw40 Antigen; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chimera Protein; Chimeric Proteins; Chronic; Circulation; Complement; Complement Proteins; Complex; Cytotoxic cell; Death; Disease; Disease Progression; Disorder; E1 protein; E1 protein, HPV-16; E1 protein, HPV16; E1 protein, Human papilloma virus 16; E1 protein, Human papillomavirus 16; ELISPOT; Enzymes; Epitopes; Estrogen Receptors; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; FRET; Fatty Liver; Fluorescence Resonance Energy Transfer; Fusion Protein; Future; G-interferon; Gene Expression; Genes; Genes, LacZ; Genes, Structural; Ginterferon; Grafting, Liver; HCV; HCV Animal Models; HCV infection; HLA-A2.1; Hepatic; Hepatitis C; Hepatitis C Therapeutics; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Host Defense; Human; Human papillomavirus 16 E1 protein; Human, General; IFN; IFN Alpha; IFNa; INFLM; Immune; Immune Function, Cellular; Immune response; Immune system; Immunologic, Immunochemical; Immunologics; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Infection; Inflammation; Injury; Interferon Alfa-n3; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Interferons; Investigators; K lymphocyte; LacZ; LacZ Genes; Liver; Liver Steatosis; Liver Transplant; MGC9013; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mice; Mice, Transgenic; Molecular; Murine; Mus; Mutate; Myelogenous; Myeloid; NANBH; NK Cells; Natural Killer Cells; Natural immunosuppression; Nerve Growth Factor Receptor-Related B-Lymphocyte Activation Molecule; Nonstructural Protein; Outcome; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Patients; Persons; Phase; Prevention Measures; Process; Production; Prophylactic treatment; Prophylaxis; Protein, Nonstructural; Receptor Gene; Reporter; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Severity of illness; Signaling Molecule; Structural Genes; Structural Protein; Subcellular Process; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TAM; TNFRSF5; TNFRSF5 Receptor; TNFRSF5 gene; Tamoxifen; Technology; Testing; The Sun; Thymus-Dependent Lymphocytes; Time; Transgenes; Transgenic Mice; Transgenic Organisms; Transplantation of liver; Transplantation, Hepatic; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Tumor Necrosis Factor Receptor Superfamily, Member 5; United States; Vaccines; Viral; Viral Antigens; Viral Gene Products; Viral Gene Proteins; Viral Pathogenesis; Viral Proteins; Virus; Viruses, General; Western Blotting; Western Blottings; Western Immunoblotting; Work; base; body system, allergic/immunologic; body system, hepatic; defense response; design; designing; disease severity; disease/disorder; enzyme linked immunospot assay; experiment; experimental research; experimental study; flexibility; gene induction; hepatic steatosis; hepatitis non A non B; hepatitis nonA nonB; host response; immune function; immunoresponse; immunosuppression; in vivo; insight; intrahepatic; liver transplantation; model organism; mouse model; new therapeutic target; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; organ system, allergic/immunologic; organ system, hepatic; p50; protein blotting; protein expression; research study; response; social role; thymus derived lymphocyte; transgenic; virus antigen; virus core; virus pathogenesis; virus protein",Immune Mechanisms of HCV Persistence and Pathogenesis,,69142,HBPP,Hepatobiliary Pathophysiology Study Section,,4,329962,
7759633,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069233-05,,NIAID:325698;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NASHVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"SKAAR, ERIC P;",6492296;,5R01AI069233,02/01/2006,01/31/2011,"Abscission; Address; Amino Acid Sequence; Animal Model; Animal Models and Related Studies; Animals; Anthrax; Anthrax disease; Appearance; B. anthracis; Bacillus anthracis; Bacterial Infections; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Blood erythrocyte; Blood normocyte; Catabolism; Cell Wall; Cell membrane; Cells; Chemistry, Biological; Chemistry, Inorganic; Clostridium tetani; Community-Acquired Infections; Complex; Coupled; Cytoplasm; Cytoplasmic Membrane; Data; Disease; Disease Progression; Disorder; Doctor of Philosophy; Drug Resistance, Multiple; Drug Resistant, Multiple; Enzymes; Erythrocytes; Erythrocytic; Excision; Extirpation; Family; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Genetic; Genomics; HOSP; Health; Heme; Heme Iron; Heme b; Hemoglobin; Hospitals; Human; Human, General; Hydroxylases; Infection; Inorganic Chemistry; Investigators; Iron; Iron-Binding Proteins; L. monocytogenes; Label; Listeria Infections; Listeria monocytogenes; Listeriosis; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mediating; Membrane; Membrane Transport; Membrane Transport Proteins; Membrane Transporters; Metalloporphyrins; Methods; Mixed Function Oxidases; Mixed Function Oxygenases; Modeling; Molecular; Molecular Interaction; Monooxygenases; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multi-Drug Resistance; Multidrug Resistance; Nutrient; Pathogenesis; Peptidyl Transferases; Peptidyl Translocases; Peptidyl-tRNA[{..}]aminoacyl-tRNA N-peptidyltransferase; Peptidyltransferase; Ph.D.; PhD; Plasma Membrane; Play; Process; Protein Binding; Protein Structure, Primary; Proteins; Protoheme; Protoheme IX; Reaction; Receptor Protein; Recombinants; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relative; Relative (related person); Removal; Reporting; Research Personnel; Researchers; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Reticuloendothelial System, Erythrocytes; Role; S. aureus; S.aureus; Series; Source; Specificity; Staphylococcus aureus; Surface; Surgical Removal; System; System, LOINC Axis 4; Tag; Testing; Tetanus; Therapeutic Intervention; Tracer; Transmembrane Transport; Transpeptidases; United States; Work; analog; anthracis; anti-microbial; antimicrobial; bacterial disease; base; blood corpuscles; clostridial tetanus; cofactor; design; designing; disease/disorder; experiment; experimental research; experimental study; ferroheme; gene product; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; iron metabolism; member; membrane structure; microbial; model organism; multi-drug resistant; multidrug resistant; mutant; new therapeutic target; novel; pathogen; plasmalemma; protein sequence; receptor; research study; resection; resistant; resistant strain; small molecule; social role; uptake",Mechanism and Function of Heme-Iron Acquisition in Staphylococcal Pathogenesis,,69233,BACP,Bacterial Pathogenesis Study Section,,5,325698,
7762203,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069253-05,,NIAID:370138;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,PATHOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"YUAN, DOROTHY C;",1881876;,5R01AI069253,02/15/2006,01/31/2011,"ATGN; Address; Affect; Antigen Presentation; Antigens; Autoantibodies; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B blood cells; B cell differentiation; B lymphocyte differentiation; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Chemosensitization; Chemosensitization/Potentiation; Chronic; Class Switching; Closure by Ligation; Cytokine Activation; Cytotoxic cell; Development; Event; Gene Transcription; Genes; Genetic Transcription; Genome; Hand; IL-13; IL13; Immunoglobulin Class Switching; Infection; Interleukin-13; Intracellular Communication and Signaling; Isotype Switching; K lymphocyte; Ligands; Ligation; Lupus Erythematosus; Mediating; Mice, Transgenic; Molecular; Mouse Strains; NK Cells; Natural Killer Cells; Nature; Pathway interactions; Potentiation; Production; Proteins; RNA Expression; Receptor Protein; Regulation; Role; SLEB1 gene; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; Symptoms; Testing; Transcription; Transcription, Genetic; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; autoimmune antibody; autoimmune disorder; biological signal transduction; cartilage link protein; experiment; experimental research; experimental study; gene product; immunogen; in vivo; insight; link protein; mRNA Expression; mouse model; pathway; receptor; receptor expression; research study; self reactive antibody; self recognition (immune); social role; systemic lupus erythematosus susceptibility 1",The role of activated NK cells in a mouse model of lupus erythematosus,,69253,ZRG1,Special Emphasis Panel,,5,370138,
7744001,R01,AI,5,,01/01/2010,12/31/2010,,5R01AI069275-04,,NIAID:317507;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATHENS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"TRIPP, RALPH A;",1948912;,5R01AI069275,01/15/2007,12/31/2010,"0-11 years old; ABCD-3; Acute; Affect; Aged 65 and Over; Antibodies; Antibodies, Blocking; Antibody Formation; Antibody Production; Antibody Response; BALB/c; Binding; Binding (Molecular Function); Blocking Antibodies; Blood Serum; Blood leukocyte; C3Xkine; CX3C; CX3C Chemokines; CX3CL1; CX3CL1 gene; CX3CR1; CXC3; CXC3C; Cell Migration Assay; Chemotaxis, Leukocyte; Child; Child Youth; Children (0-21); Delta Chemokine; Delta Chemokines; Development; Disease; Disorder; Elderly; Elderly, over 65; Embryo; Embryonic; Family; Formalin; Foundations; G glycoprotein, Respiratory syncytial virus; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Human; Human, Child; Human, General; Humoral Immunities; Immune response; Immunities, Humoral; Immunity; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunomodulation; Immunostimulation; Inbred BALB C Mice; Infant; Infection; Inflammatory Response; Investigators; Leukocyte Chemotaxis; Leukocytes; Leukotaxis; Life; Lower respiratory tract structure; Lung; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mediating; Mice, Inbred BALB C; Migration Assay; Moab, Clinical Treatment; Modification; Molecular Interaction; Monoclonal Antibodies; Mouse, BALB C; NTN; NTT; Paramyxovirus; Pathogenesis; Patients; Peptides; Play; Protein Binding; RNA Viruses; RSV G glycoprotein, Respiratory syncytial virus; RSV Vaccines; Reagent; Recombinant Delta Chemokine; Renal Cell; Research; Research Personnel; Researchers; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory System, Lung; Respiratory Tract Diseases; Respiratory syncytial virus; Respiratory syncytial virus RSV G glycoprotein; Reticuloendothelial System, Leukocytes; Role; SCYD1; Sensitization, Immunologic; Sensitization, Immunological; Serum; Severities; Severity of illness; Subunit Vaccines; Vaccination; Vaccines, Subunit; Viral Diseases; Virus Diseases; White Blood Cells; White Cell; advanced age; antibody biosynthesis; antibody-based immunity; chemokine receptor; children; disease severity; disease/disorder; elders; geriatric; glycoprotein G; host response; immune modulation; immunoglobulin biosynthesis; immunologic reactivity control; immunoregulation; immunoresponse; improved; innovate; innovation; innovative; kidney cell; late life; later life; lower respiratory tract; migration; mimicry; mouse model; older adult; older person; polypeptide; prevent; preventing; pulmonary; response; senior citizen; social role; vaccine candidate; vaccine development; vaccine efficacy; vaccine safety; viral infection; virus infection; white blood cell; white blood corpuscle; youngster",Antibody inhibition of respiratory syncytial virus G protein activity,,69275,VMD,Vaccines Against Microbial Diseases Study Section,,4,317507,
7758204,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI069289-05,,NIAID:371317;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"CHEN, YOUHAI H;",1863135;,5R01AI069289,02/01/2006,01/31/2011,"Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Axon; B-Cell CLL; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; BH3 Domain; Body Tissues; Bone Marrow; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Death; Cell Death, Programmed; Cells; Cessation of life; Characteristics; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Death; Defect; Development; Disease; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Family; Genes; Goals; Human; Human, General; INFLM; Immune Targeting; Immune system; Inflammation; Inflammatory; Injury; Investigators; Laboratories; Leukemia, B-Cell; Lymphoblastic Leukemia, Chronic; Lymphocyte; Lymphocytic; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; Lymphoid; Lymphoid Cell; MAG Protein; MOG glycoprotein; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Mature T-Cell; Mature T-Lymphocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mitochondria; Modeling; Molecular; Multiple Sclerosis; Murine; Mus; Myelin; Myelin Associated Glycoprotein; Myeloencephalitis; Myeloid Cells; N Domain; NRVS-SYS; Nature; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Organ System; Outcome; Pathogenesis; Pathway interactions; Play; Pleural Glycoproteins; Programs (PT); Programs [Publication Type]; Receptor Protein; Recovery; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Bone Marrow; Role; Sclerosis, Disseminated; T-Cells; T-Lymphocyte; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Thymus-Dependent Lymphocytes; Tissues; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; autoimmune encephalomyelitis; base; body system; body system, allergic/immunologic; chronic lymphoid leukemia; disease/disorder; effective therapy; insular sclerosis; lymph cell; member; mitochondrial; model organism; myelin glycoprotein; myelin oligodendrocyte glycoprotein; necrocytosis; neuronal; oligodendrocyte-myelin glycoprotein; organ system, allergic/immunologic; pathway; programs; receptor; resistant; response; social role; theories; thymus derived lymphocyte; treatment strategy; tumor necrosis factor (unspecified)",Autoimmune encephalomyelitis and Bcl-2- interacting mediator,,69289,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,371317,
7759531,R01,AI,5,,02/01/2010,01/31/2011,PA-04-119,5R01AI069317-04,,NIAID:329309;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LEE, BENHUR ;",2271562;,5R01AI069317,02/01/2007,01/31/2012,"ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Adulterated Food; Alanine; Alanine, L-Isomer; Antibodies; Binding; Binding (Molecular Function); Binding Sites; Biological Terrorism; Bioterrorism; Cells; Cellular Tropism; Chimera Protein; Chimeric Proteins; Combining Site; Common Rat Strains; Communicable Diseases, Emerging; Data; Development; Disease Outbreaks; EPH; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Economics; Emerging Communicable Diseases; Encephalitis; Endothelial Cells; Eph Family Receptors; Eph Receptor Tyrosine Kinase; Eph Receptors; EphA8 Protein; Ephrin Receptors; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epitope Mapping; Equine Morbillivirus; Family suidae; Farm; Farming environment; Federation of Malaya; Funding; Fusion Protein; Giant Cells; Glycoproteins; Grant; HEK3; Health; Hendra Virus; Henipavirus; Human; Human, General; In Situ; Industry; Infection; Infectious Diseases / Laboratory; Infectious Diseases Research; Infectious Diseases, Emerging; Inflammation, Brain; Investigation; Investigators; Investments; L-Alanine; Life; Ligand Binding; Light; Malay Federation; Malaya; Malaysia; Mammals, Rabbits; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Mediating; Membrane; Methods and Techniques; Methods, Other; Moab, Clinical Treatment; Molecular; Molecular Interaction; Monoclonal Antibodies; Mortality; Mortality Vital Statistics; Multinucleated Giant Cells; NIAID; National Institute of Allergy and Infectious Disease; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nipah Virus; Oryctolagus cuniculus; Outbreaks; PTK; PTK Receptors; Paramyxoviridae; Paramyxovirus; Patients; Photoradiation; Pigs; Polykaryocytes; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RTK; Rabbit, Domestic; Rabbits; Rat; Rattus; Reactive Site; Reagent; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptors, Eph Family; Receptors, Virus; Research; Research Personnel; Research Resources; Researchers; Resources; Scanning; Screening procedure; Singapore; Structure; Suidae; Swine; Syncytium; Techniques; Therapeutic; Transfection; Transmembrane Receptor Protein Tyrosine Kinase; Transmission; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vaccines; Variant; Variation; Viral; Viral Diseases; Viral Receptor; Virus; Virus Diseases; Virus Receptors; Viruses, General; agroterrorism; biodefense; coat (enveloped virus); deletion analysis; deliberate food contamination; deliberate food tampering; food terrorism; gene product; genetic immunization; genetic immunization strategies; glycoprotein G; hydroxyaryl protein kinase; intentional food contamination; intentional food tampering; intentionally adulterated food; member; membrane structure; neuronal; novel; particle; pathogen; porcine; programs; public health relevance; receptor; receptor binding; screening; screenings; small molecule; success; suid; therapeutic vaccine; transmission process; tyrosyl protein kinase; viral infection; virus envelope; virus infection",Envelope-receptor interactions in Nipah and Hendra virus pathobiology,,69317,VIRA,Virology - A Study Section,,4,329309,
7755417,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI070845-03,,NIAID:469013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"SAUER, KARSTEN ;",8454667;,5R01AI070845,02/01/2008,01/31/2013,"Animal Welfare; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Bibliography; Binding; Binding (Molecular Function); Biological; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chiro-Inositol; Country; Data; Defect; Development; Disease; Disorder; EC 2.7; Ecological impact; Economic Burden; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Figs; Figs - dietary; Future; Genetic; Genetic Screening; Graft Rejection; Healthcare Systems; IACUC; IRBs; Immune system; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Impact, Environmental; In Vitro; Individual; Inositol; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Intracellular Second Messengers; Jurkat Cells; Kinases; Ligands; Lymphocyte; Lymphocytic; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mesoinositol; Methods; Mice; Mice, Mutant Strains; Modeling; Molecular Interaction; Murine; Mus; Mutant Strains Mice; N-terminal; NH2-terminal; PH Domain; Peptides; Peripheral; Phosphotransferases; Pleckstrin-Homology Domain; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Publications; Publishing; QOL; Quality of life; RAS Family Oncogene; Receptor Signaling; Receptors, Antigen, T-Cell; Regulation; Reports, Progress; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Retrovirus Associated Sequence Oncogene; Role; Scientific Publication; Second Messenger Systems; Second Messengers; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Study Type; System; System, LOINC Axis 4; Systems, Health Care; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; TXT; Text; Thymocyte Development; Thymocyte Selection; Thymus-Dependent Lymphocytes; TimeLine; Transphosphorylases; Transplant Rejection; Transplantation Rejection; Update; Vertebrate Animals; Vertebrates; Work; abstracting; autoimmune disorder; base; biological signal transduction; body system, allergic/immunologic; cell type; computerized data processing; data processing; disability; disease/disorder; expiration; human subject; hypoimmunity; immune deficiency disorder; immunodeficiency; lymph cell; malignancy; mouse mutant; neoplasm/cancer; novel; organ system, allergic/immunologic; programs; ras Oncogene; second messenger; self recognition (immune); signal processing; social role; study design; thymocyte; thymus derived lymphocyte; vertebrata",Inositol-Trisphosphate Kinase B (ItpkB) in T Cell Development and Function,,70845,CMIB,Cellular and Molecular Immunology - B Study Section,,3,469013,
7767749,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI071025-03,,NIAID:314078;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,,30,197170756,US,CA,90073,BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE,"BEENHOUWER, DAVID OWEN;",1953872;,5R01AI071025,03/15/2008,02/28/2013,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adjuvant; Adverse effects; Animals; Antibodies; Antigen-Antibody Complex; Antigens; Binding; Binding (Molecular Function); CAPS; Cancers; Capsules; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cellular Immunity; Central Nervous System Infections; Central Nervous System Infectious Disease; Central Nervous System Infectious Disorder; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Chimera Protein; Chimeric Proteins; Chronic; Clinical, Transplantation, Organ; Co-Stimulator; Combination Chemotherapy Regimen; Communicable Diseases; Complement Activation; Complex; Costimulator; Cryptococcal Meningitis; Cryptococcosis; Cryptococcus; Cryptococcus neoformans; Cryptococcus neoformans infection; Dendritic Cells; Disease; Disorder; Dose; Edodekin Alfa; Effector Cell; Encapsulated; Epidermal Thymocyte Activating Factor; Equilibrium; Fc Receptor; FcR; Fusion Protein; GM-CSF; GMCSF; Gamma Globulin, 7S; Genetic; Globulins; Glucuronomannoxylan; Glycans; Goals; Grafting Procedure; Granulocyte-Macrophage Colony-Stimulating Factor; Granulomatous; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Half-Life; Half-Lifes; Heating; Histamine-Producing Cell-Stimulating Factor; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; IL-12; IL-2; IL12; IL2; IL2 Protein; IgG; IgG3; Immune; Immune Complex; Immune response; Immunity; Immunity, Cellular; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunoglobulin G; Immunoglobulin V; Immunoglobulin Variable Region; Immunosuppressed Host; Immunotherapeutic agent; Infection; Infection by Cryptococcus neoformans; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-12; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Investigators; Killings; Knowledge; LAV-HTLV-III; Link; Lung; Lymphadenopathy-Associated Virus; Lymphocyte Mitogenic Factor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Meningitis, Cryptococcal; Mice; Mitogenic Factor; Modeling; Molecular Interaction; Molgramostin; Mortality; Mortality Vital Statistics; Murine; Mus; Musculoskeletal Pain Disorder; NKSF; Natural Killer Cell Stimulatory Factor; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Organism; Persons; Play; Polysaccharides; Populations at Risk; Prevention; Quimioterapia; Research Personnel; Researchers; Respiratory System, Lung; Rheumatic Diseases; Rheumatism; Role; Serum Globulin; Site; Surface; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Lymphotropic Virus Type III Infections, Human; TC-GM-CSF; Talents; Testing; Therapeutic; Therapeutic Uses; Thymocyte Stimulating Factor; Torula; Torulosis; Toxic effect; Toxicities; Transplantation Surgery; Treatment Side Effects; Tumor-Cell Human GM Colony-Stimulating Factor; Vaccination; Vaccine Adjuvant; Vaccines; Variable Region; Variable Region, Ig; Veiled Cells; Virus-HIV; Yeasts; antibody receptor; application in practice; balance; balance function; cancer chemotherapy; capsule (pharmacologic); complement pathway regulation; cytokine; design; designing; disease/disorder; efficacy testing; experience; flexibility; glucuronoxylomannan; granulocyte macrophage colony stimulating factor; host response; immunogen; immunogenic; immunologic preparation; immunoresponse; immunosuppressed patient; immunotherapeutics; improved; living system; malignancy; mouse model; neoplasm/cancer; novel; organ allograft; organ graft; organ xenograft; paracrine; pathogen; practical application; prevent; preventing; prophylactic; protective efficacy; pulmonary; receptor binding; response; side effect; social role; therapeutic vaccine; therapy adverse effect; treatment adverse effect; tumor; uptake; vaccination strategy",Antibody cytokine fusion proteins against Cryptococcus neoformans,,71025,VMD,Vaccines Against Microbial Diseases Study Section,,3,314078,
7761204,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI071028-03,,NIAID:303435;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,KANSAS CITY,UNITED STATES,ANATOMY/CELL BIOLOGY,05,010989619,US,MO,64110,UNIVERSITY OF MISSOURI KANSAS CITY,"GEISBRECHT, BRIAN ;",8485615;,5R01AI071028,02/01/2008,01/31/2013,"Address; Agreement; Animal Welfare; Anti-Bacterial Agents; Antibacterial Agents; Ascaridil; Attenuated; Authorship; Autoimmune; Autoimmune Process; Bacterial Gene Proteins; Bacterial Proteins; Bibliography; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood Poisoning; Budgets; C3 d; C3b; C3d; C3d,g; C3dg; CD 21 Antigens; CD21; CD21 Antigens; CR2; Calorimetry; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Catheters; Characteristics; Clinical; Coagulation Factor I; Coagulation Factor One; Collaborations; Combining Site; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Community-Acquired Infections; Complement; Complement 3; Complement 3b; Complement 3d; Complement 3d Receptors; Complement Activation; Complement C3b; Complement C3d; Complement Component 3; Complement Factor H; Complement Inactivators; Complement Inhibitors; Complement Proteins; Complement Receptors 2; Complex; Country; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; DNA Molecular Biology; Data; Data Collection; Decaris; Disease; Disorder; Dissociation; Ecological impact; Editorial Comment; Editorial Comment (PT); Endocarditis; Environment; Environmental Impact; Epstein-Barr Virus Receptors; Equilibrium; Equipment; Ergamisol; Ergamisole; Ethics Committees, Research; Evolution; Exposure to; Factor H; Factor I; Factor One; Family; Fibrin; Fibrinogen; Figs; Figs - dietary; Funding; Gene Products, Bacterial; GeneHomolog; Genetics-Mutagenesis; Genomics; Hand; Health; Homolog; Homologous Gene; Homologous Protein; Homologue; Human; Human, General; IACUC; IRBs; Immune response; Immune system; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunol; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosuppressants; Immunosuppressive Agents; Impact, Environmental; Implant; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Journals; Ketrax; Kinetic; Kinetics; Knowledge; Laboratories; Lead; Ligand Binding Protein; Ligands; Link; Literature; Longitudinal Studies; Magazine; Man (Taxonomy); Man, Modern; Masks; Measures; Mediating; Medical Device; Modeling; Molecular; Molecular Biology; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; N-terminal; NH2-terminal; Natural Immunity; Nature; Organ System, Cardiovascular; Organism; Pace Stimulators; Pacemakers; Paper; Pathogenicity Factors; Pb element; Peptide Synthesis; Peptides; Physiologic; Physiological; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Protein Homolog; ProteinHomolog; Proteins; Publications; Published Comment; Publishing; Pump; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Receptors, C3d; Receptors, CR2; Receptors, Complement 3d; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Roentgen Rays; Role; S. aureus; S.aureus; Scanning; Science; Scientific Publication; Screening procedure; Septicemia; Series; Single Crystal Diffraction; Solaskil; Staphylococcus aureus; Stimulators, Electrical, Pace; Structure; Structure-Activity Relationship; Suggestion; Surface; Surface Plasmon Resonance; System; System, LOINC Axis 4; Testing; Time; Titrations; Tramisol; Trimisol; Update; Variant; Variation; Vascular, Heart; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Virulence Factors; Work; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; abstracting; activation product; anti-bacterial; antibacterial; balance; balance function; base; bioincompatibility; biomaterial incompatibility; body system, allergic/immunologic; chemical structure function; circulatory system; complement 3d,g; complement C3d,g; complement pathway regulation; conformation; conformational state; cross-link; crosslink; design; designing; disease/disorder; experience; experiment; experimental research; experimental study; expiration; extracellular; gene product; heavy metal Pb; heavy metal lead; host response; human subject; immunoresponse; immunosuppressive; inhibitor; inhibitor/antagonist; insight; living system; long-term study; novel; organ system, allergic/immunologic; pathogen; programs; protein function; protein protein interaction; protein purification; protein structure function; research study; response; screening; screenings; septicaemia; social role; structure function relationship; success; vertebrata",Structure Function Analysis of Staphylococcal Complement Inhibitors,,71028,III,Innate Immunity and Inflammation Study Section,,3,303435,
7756646,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI071043-03,,NIAID:308107;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,UNIVERSITY PARK,UNITED STATES,VETERINARY SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"XIONG, NA ;",2202447;,5R01AI071043,02/15/2008,01/31/2013,"Affect; Animal Welfare; BN-1 Gene; Bibliography; Body Tissues; C-C CKR-6 Gene; C-C Chemokine Receptor Type 6 Gene; CC Chemokine Receptor 10 Gene; CC-CKR-6 Gene; CCR-6 Gene; CCR10; CCR6; CCR6 gene; CKR-L3 Gene; CKR6 Gene; CKRL3 Gene; CMKBR6 Gene; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Migration; Chemokine (C-C) Receptor 6 Gene; Chemokine Receptor-Like 3 Gene; Complex; Country; Critiques; DCR2 Gene; DRY-6 Gene; DRY6 Gene; Data; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug or chemical Tissue Distribution; Ecological impact; Environment; Environmental Impact; Epithelial; Equipment; Ethics Committees, Research; Future; G Protein-Coupled Receptor 29 Gene; GPR-CY4 Gene; GPR2; GPR2 gene; GPR29 Gene; GPRCY4 Gene; Generations; Homing; IACUC; INFLM; IRBs; Immune; Impact, Environmental; Infection; Inflammation; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knockout Mice; Knowledge; LARC Receptor Gene; Ligands; Lymphocyte; Lymphocytic; Lymphoid; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular; Motility; Motility, Cellular; Murine; Mus; Null Mouse; Organ; Peripheral; Position; Positioning Attribute; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Receptors, Antigen, T-Cell; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Thymus; STRL22 Gene; Seven-Transmembrane Receptor, Lymphocyte, 22 Gene; Skin; Suggestion; Surface; T-Cell Receptor; T-Cells; T-Lymphocyte; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissue Distribution; Tissues; Transgenic Mice; Transgenic Organisms; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Wound Healing; Wound Repair; abstracting; cell motility; chemokine receptor; disease/disorder; experience; expiration; fetal; fight against; human subject; lymph cell; migration; mouse model; programs; prototype; thymus derived lymphocyte; tissue repair; transgenic; tumor; tumor growth; vertebrata",Positive Selection-Dependent Skin-Homing of Fetal Thymic Gamma/Delta T Cells,,71043,III,Innate Immunity and Inflammation Study Section,,3,308107,
7761245,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI071047-03,,NIAID:365204;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOUISVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"MITCHELL, THOMAS C;",1945664;,5R01AI071047,02/01/2008,01/31/2013,"1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-; 2,6,8-Trihydroxypurine; Acids; Adjuvant; Agonist; Alum Adjuvant; Animal Welfare; Antibody Formation; Antibody Production; Antibody Response; B blood cells; B-Cells; B-Lymphocytes; Bibliography; Blood monocyte; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Signaling; Cells, CD4; Clinical; Clonal Expansion; Country; Data; Drug Formulations; Ecological impact; Endotoxins; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Europe; Figs; Figs - dietary; Formulation; Formulations, Drug; Future; Gout; IACUC; IRBs; Impact, Environmental; In Vitro; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Marrow monocyte; Mediating; Molecular; Nature; Nucleic Acids; Parents; Pathway interactions; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Publishing; Reagent; Relative; Relative (related person); Research; Research Ethics Committees; Research Resources; Resources; Science; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TLR4; TLR4 gene; TOLL; Testing; Thymus-Dependent Lymphocytes; Time; Toxic effect; Toxicities; Trioxopurine; Uric Acid; Vaccination; Vaccine Adjuvant; Vaccines; Variant; Variation; Vertebrate Animals; Vertebrates; abstracting; alum; aluminum sulfate; antibody biosynthesis; base; biological signal transduction; design; designing; expiration; gene product; hToll; helper T cell; human subject; immunoglobulin biosynthesis; improved; in vivo; interest; lipid A MP; monocyte; monophosphoryl lipid A; next generation; pathway; programs; prophylactic; safety testing; success; thymus derived lymphocyte; vertebrata; ward",Adjuvant Functions of Detoxified LPS,,71047,IHD,Immunity and Host Defense Study Section,,3,365204,
7749934,R01,AI,5,,01/01/2010,12/31/2010,PA-07-070,5R01AI071199-03,,NIAID:368775;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,KANSAS CITY,UNITED STATES,PHARMACOLOGY,05,010989619,US,MO,64110,UNIVERSITY OF MISSOURI KANSAS CITY,"MITRA, ASHIM K;",6783677;,5R01AI071199,01/15/2008,12/31/2011,"ABCB1; AIDS; AIDS Drugs; AIDS Virus; ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; Absorption; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Animal Welfare; Anti-AIDS Agents; Anti-AIDS Drugs; Anti-HIV Agents; Anti-HIV Drugs; Anti-Human Immunodeficiency Virus Agents; Antiproteases; Antiretroviral Therapy, Highly Active; Antiviral Agents; Antiviral Drugs; Antivirals; Applications Grants; Bibliography; Binding; Binding (Molecular Function); Bioavailability; Biologic Availability; Biological Availability; Blood; Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Critiques; Diffusion; Dipeptides; Dose; Drug Precursors; Drug Resistance, Multiple; Drug Resistant, Multiple; Drugs; Ecological impact; Editorial Comment; Editorial Comment (PT); Encephalon; Encephalons; Endopeptidase Inhibitors; Environment; Environmental Impact; Equipment; Esteroproteases; Ethics Committees, Research; Fortovase; Grant Proposals; Grants, Applications; HAART; HIV; HIV Protease Inhibitors; HTLV-III; Hemato-Encephalic Barrier; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IACUC; IRBs; Immunologic Deficiency Syndrome, Acquired; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; L-valyl-L-valine; LAV-HTLV-III; Link; Lipids; Lymphadenopathy-Associated Virus; MDR1 Protein; Medication; Modification; Molecular; Molecular Interaction; Molecular Weight; Multi-Drug Resistance; Multidrug Resistance; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Nervous System, Brain; Occluding Junctions; Oral; Outcome; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein Transporter; P-Glycoproteins; PGY-1 Protein; Patients; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic Availability; Principal Investigator; Pro-Drugs; Process of absorption; Prodrugs; Programs (PT); Programs [Publication Type]; Protease Antagonists; Protease Inhibitor; Proteases; Proteinase Inhibitors; Proteinases; Proteins; Proteolytic Enzymes; Published Comment; Regimen; Relative; Relative (related person); Research; Research Ethics Committees; Research Resources; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Resources; Reticuloendothelial System, Blood; SQV; Saquinavir; Saquinivir; Solubility; Therapeutic Agents; Tight Junctions; Val-Val; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral; Virus-HIV; Weight; Zonula Occludens; absorption; abstracting; analog; anti-retroviral therapy, highly active; antiAIDS agent; bioavailability of drug; drug/agent; expiration; gene product; human subject; improved; multi-drug resistant; multidrug resistant; prevent; preventing; programs; valylvaline; vertebrata",Protease Inhibitor Analogues for Enhanced Transport Across Blood-Brain Interfaces,,71199,ZRG1,Special Emphasis Panel,,3,368775,
7761259,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI071233-04,,NIAID:367641;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"DAVID, MICHAEL ;",2095036;,5R01AI071233,02/15/2007,01/31/2011,"ATP[{..}]protein-tyrosine O-phosphotransferase; Activation, Gene; Affect; Aldesleukin Gene; Attenuated; Autoimmune Diseases; Biological; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Co-Stimulator; Costimulator; DNA Binding; DNA Binding Interaction; DNA Modification; DNA Modification Process; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Elements; Enhancer Elements; Enhancer Elements (Genetics); EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Thymocyte Activating Factor; Event; Exposure to; Family; Gene Activation; Gene Expression; Gene Transcription; Genetic Transcription; HEK3; Histones; Human; Human, General; IFN; IL-2; IL-2 Gene; IL2; IL2 Protein; IL2 gene; ISFG-3; ISGF-3; Immune response; In element; Indium; Inflammatory Response; Interferon Receptor; Interferon Type I; Interferons; Interleukin 2; Interleukin 2 Precursor; Interleukin 2 Precursor Gene; Interleukin II; Interleukin-2; Interleukin-2 Gene; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Investigators; L-Tyrosine; Lead; Light; Lymphocyte Mitogenic Factor; MHC Receptor; MS (Multiple Sclerosis); MTGN; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mitogenic Factor; Mitogens; Molecular; Multiple Sclerosis; Murine; Mus; Nucleus; P113; PTK; Pathway interactions; Pb element; Photoradiation; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; RNA Expression; Receptor Signaling; Receptors, Antigen, T-Cell; Regulation; Research Personnel; Researchers; Role; STAT protein; STAT1; STAT1 gene; STAT113; STAT2; STAT2 gene; STAT91; Sclerosis, Disseminated; Signal Transducer and Activator of Transcription; Signal Transduction; Signal Transduction Systems; Signaling; T cell growth factor; T-Cell Activation; T-Cell Growth Factor; T-Cell Growth Factor Gene; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; TCGF Gene; TYR; Testing; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Tyrosine; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Up-Regulation; attenuation; autoimmune disorder; biological signal transduction; cell growth; chromatin remodeling; clinical applicability; clinical application; cytokine; genetic enhancer element; genetic promoter element; heavy metal Pb; heavy metal lead; host response; hydroxyaryl protein kinase; immunoresponse; insight; insular sclerosis; para-Tyrosine; pathway; programs; protein expression; response; social role; thymus derived lymphocyte; transcription factor; tyrosyl protein kinase",Interferon actions and autoimmune disorders,,71233,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,4,367641,
7755823,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI071727-04,,NIAID:326667;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ANN ARBOR,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"ONO, AKIRA ;",8501225;,5R01AI071727,02/01/2007,01/31/2012,"AIDS Drugs; AIDS Virus; Accounting; Address; Affect; Amino Acid Substitution; Amino Acids; Anti-AIDS Agents; Anti-AIDS Drugs; Anti-HIV Agents; Anti-HIV Drugs; Anti-Human Immunodeficiency Virus Agents; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Cell Membrane Lipids; Cell membrane; Cells; Clone Cells; Coupled; Cytoplasmic Membrane; Data; Defect; Dependence; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Enzymes; Factor Analyses; Factor Analysis; Fluorescence Microscopy; Future; Gagging; Goals; HIV-1; HIV-I; HIV1; HeLa; Hela Cells; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; In Vitro; Infection; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intervention; Intervention Strategies; Lead; Ligand Binding Protein; Lipid Binding; Lipids; Liposomal; Liposomes; Location; MVB; Measurement; Mediating; Membrane; Membrane Lipids; Membrane Transport; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular; Molecular Interaction; Multivesicular Body; Pathway interactions; Pb element; Peptide Domain; Phosphatases; Phosphatides; Phosphatidyl Inositol; Phosphatidyl Inositol Phosphates; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphohydrolases; Phosphoinositides; Phospholipids; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Plasma Membrane; Play; Polyphosphoinositides; Process; Production; Protein Domains; Protein Trafficking; Proteins; PtdIns; Recycling; Reflex, Pharyngeal; Regulatory Protein; Reporting; Research Proposals; Resistance; Role; Series; Site; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Tertiary Protein Structure; Testing; Thymus-Dependent Lymphocytes; Traffickings, Protein; Translations; Transmembrane Transport; VESCL; Vesicle; Viral; Viral Structural Proteins; Virion; Virus; Virus Assembly; Virus Particle; Virus-like particle; Viruses, General; aminoacid; antiAIDS agent; base; cell type; experiment; experimental research; experimental study; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; instrument; interventional strategy; late endosome; macrophage; membrane structure; mutant; overexpression; particle; pathway; plasmalemma; protein transport; regulatory gene product; research study; resistant; social role; thymus derived lymphocyte; trafficking; viruslike particle",Mechanisms that determine subcellular sites of HIV-1 assembly,,71727,AMCB,AIDS Molecular and Cellular Biology Study Section,,4,326667,
7776827,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI072004-03,,NIAID:386471;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"DESROSIERS, RONALD C;",1862806;,5R01AI072004,03/01/2008,02/28/2013,"Amino Acid Sequence; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Assay; B blood cells; B-Cells; B-Lymphocytes; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell fusion; Cells; Characteristics; Code; Coding System; Codon; Codon Nucleotides; Complex; Dependence; Development; Disease; Disorder; Endothelial Cells; Family; Fibroblasts; Gene Therapy Vectors; Gene Transduction Agent; Gene Transduction Vectors; Genes; Genes, Viral; Genetic; Genetic Polymorphism; Glycoproteins; HHV-8; HHV8; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesviridae; Herpesvirus hominis; Herpesviruses; Immune response; Individual; Infection; Intracellular Communication and Signaling; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Knock-out; Knockout; Learning; Light; Macaca mulatta; Mediating; Modeling; Monkeys; Photoradiation; Polymorphism (Genetics); Polymorphism, Genetic; Pressure; Pressure- physical agent; Process; Property; Property, LOINC Axis 2; Protein Structure, Primary; Reading Frames; Receptor Protein; Recombinants; Relative; Relative (related person); Rhadinovirus; Rhesus; Rhesus Macaque; Rhesus Monkey; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Simplexvirus; Specificity; System; System, LOINC Axis 4; Testing; Time; Vaccines; Variant; Variation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Proteins; Virus; Virus-HHV8; Viruses, General; antibody biosynthesis; base; biological signal transduction; cell type; disease/disorder; experiment; experimental research; experimental study; gamma-2 herpesvirus; genome sequencing; herpes virus; herpesvirus; host response; human herpesvirus 1 group; human herpesvirus 8; immunoglobulin biosynthesis; immunoresponse; insight; knockout gene; mutant; neutralizing antibody; polymorphism; pressure; prevent; preventing; protein sequence; receptor; recombinant virus; research study; virus host interaction; virus protein","Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization",,72004,VIRA,Virology - A Study Section,,3,386471,
7826746,R01,AI,5,,02/10/2010,01/31/2011,PA-07-070,5R01AI072060-04,,NIAID:370508;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GALVESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"WANG, TIAN ;",7018053;,5R01AI072060,02/01/2008,01/31/2013,"3 year old; ATGN; Address; Adjuvant; Adoptive Transfer; Affect; Age; Aged 65 and Over; Aging; Animals; Antigens; Arbovirus, Group B; Budgets; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Aging; Cell Senescence; Cells; Cells, CD4; Cellular Aging; Cessation of life; Data; Death; Development; Disease Outbreaks; Dysfunction; ELIG; Egypt 101 virus; Elderly; Elderly, over 65; Eligibility; Eligibility Determination; Encephalitis; Encephalitis, Viral; Experimental Designs; Flavivirus; Frequencies (time pattern); Frequency; Functional disorder; Generations; Goals; Human; Human, General; IACUC; Immune; Immunity; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Infection; Infectious Encephalomyelitis, Viral; Inflammation, Brain; Institutional Animal Care and Use Committee; Investigators; LYT3; Lead; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Memory; Mice; Murine; Mus; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; North America; Outbreaks; Pb element; Phenotype; Physiopathology; Population; Predisposition; Protocol; Protocol Screening; Protocols documentation; Public Health; Publishing; Research Personnel; Researchers; Risk; Rodent; Rodentia; Rodentias; Role; Secondary to; Senescence; Senescence, Cellular; Senescence, Replicative; Staging; Susceptibility; T cell regulation; T memory cell; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Vaccination; Vaccine Design; Vaccines; Viral; Viral Diseases; Viral Encephalitis; Virus Diseases; WNV; West Nile; West Nile virus; advanced age; aged; animal facility; cell age; cost; elders; experience; geriatric; heavy metal Pb; heavy metal lead; helper T cell; high risk; immunogen; immunosuppressed patient; improved; insight; interest; late life; later life; memory CD4 T cell; memory CD4 T lymphocyte; memory T lymphocyte; microbial; nervous system disorder; neurological disease; older adult; older person; pathogen; pathophysiology; public health medicine (field); reconstitute; reconstitution; response; senescent; senior citizen; social role; three year old; thymus derived lymphocyte; vaccine development; vector; viral infection; virus infection; web site",Gammadelta T cell Regulation of Adaptive Immunity in West Nile Virus Infection,,72060,IHD,Immunity and Host Defense Study Section,,4,370508,
7759571,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI072252-04,,NIAID:411543;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,PATHOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"VON ANDRIAN, ULRICH H;",1897554;,5R01AI072252,02/01/2007,01/31/2012,"ATGN; Address; Affect; Affinity; Animals; Antigens; Apoptosis; Apoptosis Pathway; Area; Autoimmune Diseases; B blood cells; B-Cells; B-Lymphocytes; Behavior; Behavioral; Blood; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD8; CD8B; CD8B1; CD8B1 gene; CTL; Cell Communication; Cell Communication and Signaling; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Interaction; Cell Mediated Immunology; Cell Process; Cell Signaling; Cell physiology; Cell-Mediated Cytolysis; Cell-Mediated Immunity; Cell-Mediated Lympholysis; Cell-Mediated Lympholytic Cells; Cell-to-Cell Interaction; Cells; Cellular Cytotoxicity; Cellular Function; Cellular Immunity; Cellular Physiology; Cellular Process; Clinical; Communication; Contracting Opportunities; Contracts; Cytolysis; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxicity, Immunologic; Dendritic Cells; Development; Effector Cell; Event; Generations; Height; High Endothelial Venule; History; Home; Home environment; IVM; Image; Imagery; Imaging technology; Immunity, Cellular; Immunomodulation; In Situ; Inflammatory; Intracellular Communication and Signaling; Killings; Kinetic; Kinetics; Knowledge; LYT3; Label; Lead; Left; Licensing; Life; Link; Lymph; Lymph Node Cortex; Lymph node proper; Lymphatic; Lymphocyte Cytotoxicity; Lymphocytotoxicity; Lymphoid; Lysis; Lytotoxicity; Mammals, Mice; Mediating; Memory; Mice; Modeling; Molecular; Murine; Mus; Nature; Organ; Outcome; Pb element; Peptides; Peripheral; Phase; Physiologic pulse; Population; Process; Proliferating; Proteins; Pulse; Q-Dot; Quantum Dots; Recording of previous events; Regulation; Regulatory T-Lymphocyte; Reporter; Resolution; Reticuloendothelial System, Blood; Reticuloendothelial System, Lymph; Reticuloendothelial System, Lymph Node; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Subcellular Process; Surface; T cell regulation; T-Cell Activation; T-Cell Receptor Interaction; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; TCR Activation; TCR Interaction; Testing; Thymus-Dependent Lymphocytes; Time; Tissues; Transgenic Organisms; Vaccination; Veiled Cells; Visualization; Withdrawal; Work; autoimmune disorder; biological signal transduction; career; cell behavior; cell mediated cytotoxicity; cell mediated immune response; combinatorial; cytokine; cytotoxic; cytotoxicity; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; imaging; immune modulation; immunogen; immunologic reactivity control; immunoregulation; improved; in vivo; in vivo Model; insight; intravital microscopy; lymph gland; lymph nodes; lymphatic fluid; movie; multi-photon; new approaches; novel; novel approaches; novel strategies; novel strategy; photonics; prevent; preventing; research study; response; social role; thymus derived lymphocyte; trafficking; transgenic; tumor",Differentiation and Regulation of CTL,,72252,CMIB,Cellular and Molecular Immunology - B Study Section,,4,411543,
7759592,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI072345-03,,NIAID:430650;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"STENLUND, ARNE ;",2456550;,5R01AI072345,02/01/2008,01/31/2012,"Address; Affect; Amino Acid Sequence; Animal Welfare; Antibodies; Benign; Bibliography; Biochemical; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; Crystallization; DNA; DNA Binding; DNA Binding Interaction; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; DNA, Viral; Deoxyribonucleic Acid; Development; Disease; Disorder; E1 protein; E1 protein, HPV-16; E1 protein, HPV16; E1 protein, Human papilloma virus 16; E1 protein, Human papillomavirus 16; EMSA; Ecological impact; Editorial Comment; Editorial Comment (PT); Elements; Environment; Environmental Impact; Epithelium; Equipment; Ethics Committees, Research; Evaluation; Figs; Figs - dietary; France; Frequencies (time pattern); Frequency; Funding; Genetic; Genome; Goals; Human papillomavirus 16 E1 protein; IACUC; IRBs; Impact, Environmental; In Vitro; Incubated; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Laboratories; Life Cycle; Life Cycle Stages; Literature; Malignant; Malignant - descriptor; Measures; Minor; MnO4(1-); MnO4-; Modification; Molecular Biology, Protein Sequencing; Nature; Nuclear Extract; Papilloma Viruses; Papillomavirus; Pathway interactions; Peptide Sequence Determination; Philosophy; Phosphorylation; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Sequencing; Protein Structure, Primary; Published Comment; Replication Initiation; Replication Origin; Replication Unit; Replicon; Reports, Progress; Research; Research Ethics Committees; Research Resources; Resistance; Resources; Risk; Role; Running; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Sorting - Cell Movement; Specificity; Staging; System; System, LOINC Axis 4; Testing; Therapeutic; Transmission; Variant; Variation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Viruses, General; abstracting; base; cell transformation; disease/disorder; experiment; experimental research; experimental study; expiration; human disease; human subject; in vivo; information gathering; information processing; interest; life course; melting; mutant; ori Region; pathway; permanganate; programs; protein sequence; research study; resistant; response; social role; sorting; transformed cells; transmission process; tumor; vertebrata; viral DNA; virus DNA; virus protein",Biochemical analysis of papillomavirus replication,,72345,VIRA,Virology - A Study Section,,3,430650,
7755404,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI072429-03,,NIAID:329644;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"BARTON, GREGORY M;",3057251;,5R01AI072429,02/01/2008,01/31/2013,"Address; Animal Welfare; Animals; Autoimmune Status; Autoimmunity; Bacterial Genome; Bibliography; Biochemical; Biology; Cell surface; Cells; Cellular biology; Cognitive Discrimination; Collaborations; Country; DNA; Deoxyribonucleic Acid; Detection; Discrimination; Discrimination (Psychology); Double Stranded DNA Virus; Double-Stranded DNA; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Genome, Bacterial; Goals; Grant; Human; Human, General; IACUC; IRBs; Immune response; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Lead; Ligands; Longitudinal Studies; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Murine; Mus; Nucleic Acids; Pathology; Pathway interactions; Patients; Pb element; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Receptor Protein; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; SLE; SLE - Lupus Erythematosus, Systemic; Sampling; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; TLR protein; TLR9 protein; TLR9 receptor; Techniques; Testing; Time; Toll-like receptor 9; Toll-like receptors; Vertebrate Animals; Vertebrates; Viral; Virus; Viruses, General; Work; abstracting; cell biology; cost; disseminated lupus erythematosus; ds-DNA; dsDNA Virus; expiration; heavy metal Pb; heavy metal lead; host response; human disease; human subject; immunoresponse; long-term study; mutant; novel; pathway; prevent; preventing; programs; receptor; response; self recognition (immune); social role; systemic lupus erythematosis; trafficking; vertebrata",The cell biology of Toll-like receptor 9: a mechanism to prevent autoimmunity,,72429,III,Innate Immunity and Inflammation Study Section,,3,329644,
7761229,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI072584-03,,NIAID:334125;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLLEGE PARK,UNITED STATES,ANATOMY/CELL BIOLOGY,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"BRIKEN, VOLKER ;",6903881;,5R01AI072584,02/01/2008,01/31/2013,"AIDS/HIV; AIDS/HIV problem; Address; Animal Welfare; Apoptosis; Apoptosis Pathway; Apoptotic; Attenuated Vaccines; Bacteria; Bacterial Infections; Bibliography; Cell Death, Programmed; Cells; Collaborations; Country; Data; Development; Drug Delivery; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Drug resistance; Drugs; Ecological impact; Environment; Environmental Impact; Epidemic; Equipment; Ethics Committees, Research; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genus Mycobacterium; HIV/AIDS; HIV/AIDS problem; IACUC; IRBs; Immune response; Immunocompetent; Impact, Environmental; Individual; Infection; Inhibition of Apoptosis; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Lead; Life; Link; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Mammals, Mice; Medication; Mice; Minor; Molecular; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Mutation; Mycobacterium; Mycobacterium tuberculosis; NIH; National Institutes of Health; National Institutes of Health (U.S.); Paper; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Postdoc; Postdoctoral Fellow; Principal Investigator; Programs (PT); Programs [Publication Type]; Recruitment Activity; Research; Research Associate; Research Ethics Committees; Research Resources; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Resources; TB vaccine; Testing; Tuberculosis; Tuberculosis Vaccines; United States National Institutes of Health; Vaccines; Vaccines, Attenuated; Vertebrate Animals; Vertebrates; Virulence; Work; abstracting; anti-TB vaccine; bacterial disease; base; disseminated TB; disseminated tuberculosis; drug resistant; drug/agent; expiration; gain of function; genome mutation; graduate student; heavy metal Pb; heavy metal lead; host response; human subject; immunoresponse; improved; live vaccine; macrophage; mouse model; multi-drug resistant; multidrug resistant; mutant; mycobacterial; pathogen; pathway; post-doc; post-doctoral; programs; recruit; resistance to Drug; resistant to Drug; success; synergism; tuberculosis drugs; tuberculous spondyloarthropathy; vertebrata",Mechanism of host cell apoptosis inhibition by Mycobacterium tuberculosis,,72584,HIBP,Host Interactions with Bacterial Pathogens Study Section,,3,334125,
7760892,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI072644-03,,NIAID:320760;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TOLEDO,UNITED STATES,BIOLOGY,09,051623734,US,OH,436063328,UNIVERSITY OF TOLEDO,"KOMUNIECKI, RICHARD WALTER;",3084193;,5R01AI072644,02/01/2008,01/31/2013,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT Receptors; 5-Hydroxytryptamine; 5-Hydroxytryptamine Receptors; 5HT; Animal Welfare; Bancroftian Elephantiasis; Behavior; Bibliography; Bio-Informatics; Biogenic Amine Receptors; Bioinformatics; Biological Models; Brugia malayi; C elegans; C.elegans; CD2 Antigens; CD2 molecule; CD2R; Caenorhabditis elegans; Cell Communication and Signaling; Cell Signaling; Country; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E-Rosette Receptor; Ecological impact; Enteramine; Environment; Environmental Impact; Equilibrium; Equipment; Ethics Committees, Research; Farm Animal; Filarial Elephantiases; Genes; Genetic; Gray; Gray unit of radiation dose; Health; Hippophaine; Human; Human, General; IACUC; IRBs; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Life; Livestock; Livestocks; Locomotion; Lymphatic Filariasis; Lymphocyte-Function Antigen-2, LFA-2; Man (Taxonomy); Man, Modern; Model System; Models, Biologic; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscular Contraction; Nematoda; Nematodes; Nutrition; Nutritional Science; Ocular Onchocerciasis; Onchocerciasis, Ocular; Parasites; Parasitic nematode; Pathway interactions; Physiologic; Physiological; Plants; Plants, General; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; Pump; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; River Blindness; Role; SER receptor; SRBCR; Science of nutrition; Serotonin; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; System; System, LOINC Axis 4; T11 Erythrocyte-Binding Glycoprotein; Testing; Vertebrate Animals; Vertebrates; abstracting; balance; balance function; biological signal transduction; chemotherapy; design; designing; disability-adjusted life years; drug discovery; economic impact; egg; expiration; expression cloning; gene product; human morbidity; human subject; mutant; nutrition; pathway; programs; receptor; roundworm; serotonin receptor; sheep erythrocyte receptor; sheep red blood cell receptor; social role; tyramine receptor; vertebrata",Locomotion in Parasitic Nematodes,,72644,PTHE,Pathogenic Eukaryotes Study Section,,3,320760,
7758380,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI072648-03,,NIAID:310860;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SYRACUSE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"PERL, ANDRAS ;",1895374;,5R01AI072648,02/01/2008,01/31/2013,"1, 2-Dehydrocortisone; ATP Synthesis; ATP Synthesis Pathway; Accounting; Address; Animal Welfare; Apoptosis; Apoptosis Pathway; Autoimmune Status; Autoimmunity; Bibliography; Biogenesis; Blood monocyte; Blotting, Western; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cells; Cessation of life; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Consultations; Country; Critiques; DNA, Mitochondrial; Data; Death; Defect; Dehydrocortisone; Delta(1)-Cortisone; Deltacortisone; Deltadehydrocortisone; Disease; Disorder; Drugs; Ecological impact; Editorial Comment; Editorial Comment (PT); Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FK506-Binding Protein 1; FK506-Binding Protein 1A; FKBP-12; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Figs; Figs - dietary; Gene Expression; Gene Products, RNA; Genes; Genes, rRNA; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Hereditary; History; Hydroxychlorochin; Hydroxychloroquine; IACUC; INFLM; IRBs; Impact, Environmental; In Vitro; Inflammation; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Laboratories; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; MMF; MNSOD; Macrophilin-12; Marrow monocyte; Measures; Medication; Membrane Potentials; Metabolic Control; Metacortandracin; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Molecular; Mononitrogen Monoxide; Mycophenolate Mofetil (Cellcept); Necrosis; Necrotic; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear; Origin of Life; Outer Mitochondrial Membrane Protein Porin-1; Oxychlorochin; Oxychloroquine; Pathology; Patients; Peptide Biosynthesis, Ribosomal; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphorylation; Plasmalemmal Porin; Porin 31HL; Porin 31HL, human; Porin 31HM; Porin 31HM, human; Prednisone; Prednisonum; Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Phosphorylation; Protein Synthesis, Ribosomal; Proteins; Publications; Published Comment; RAFT1 protein, human; RAPT1 protein, human; RNA; RNA, Non-Polyadenylated; Rapamune; Rapamycin; Rapamycin Target Protein; Recording of previous events; Research; Research Ethics Committees; Research Resources; Resources; Resting Potentials; Ribonucleic Acid; Ribonucleic acids, transfer; Ribosomal RNA Genes; SLE; SLE - Lupus Erythematosus, Systemic; SOD2; SOD2 gene; Scientific Publication; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T-Cell Activation; T-Cells; T-Lymphocyte; Tacrolimus Binding Protein 1A; Thymus-Dependent Lymphocytes; Transfer RNA; Transmembrane Potentials; Triplet Codon-Amino Acid Adaptor; VDAC-1; VDAC1 protein; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Voltage-Dependent Anion-Selective Channel Protein-1; Voltage-Dependent_Anion_Channel-1; Western Blotting; Western Blottings; Western Immunoblotting; Work; Writing; abstracting; base; biological signal transduction; delta-Cortisone; disease/disorder; disseminated lupus erythematosus; drug/agent; endothelial cell derived relaxing factor; ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-; expiration; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; hVDAC1; human FRAP1 protein; human lymphocyte membrane protein 31; human subject; innovate; innovation; innovative; mTOR; mitochondrial; monocyte; mtDNA; mycophenolate mofetil; mycophenolic acid morpholinoethyl ester; necrocytosis; programs; protein blotting; protein synthesis; rRNA Genes; rapamycin and FKBP12 target 1 protein, human; reactive oxygen intermediate; self recognition (immune); shRNA; short hairpin RNA; small hairpin RNA; systemic lupus erythematosis; tRNA; thymus derived lymphocyte; vertebrata",Metabolic control of systemic autoimmunity,,72648,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,3,310860,
7759161,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI072737-13,,NIAID:379315;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,BIOCHEMISTRY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"GOVERMAN, JOAN M;",1866594;,5R01AI072737,02/15/2007,01/31/2012,"APC; ATGN; Affinity; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Binding Determinants; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Causality; Cell Surface Antigens; Cells; Cells, CD4; Central Nervous System; Characteristics; Clinical; Complex; Demyelinating Disease of Central Nervous System; Demyelinating Disorder of Central Nervous System; Development; Disease; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Epitopes; Etiology; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Funding; Genes, Class I; Genes, MHC Class I; Goals; Home; Home environment; Homing; Immune Tolerance; Immunity; Immunologic Accessory Cells; Immunologic Tolerance; In Vitro; Infection; Infiltration; Inflammatory; LYT3; Laboratories; MHC Class I; MHC Class I Genes; MHC Receptor; MS (Multiple Sclerosis); Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Mice; Modeling; Molecular; Monocytes / Macrophages / APC; Mouse Strains; Multiple Sclerosis; Murine; Mus; Myelin; Myelin Basic Proteins; Myeloencephalitis; Nervous System Diseases; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, CNS; Neuraxis; Neurologic; Neurologic Disorders; Neurological; Neurological Damage; Neurological Disorders; Neurological Injury; Neurological trauma; Pathogenesis; Pathologic; Pathology; Patients; Peripheral; Receptors, Antigen, T-Cell; Sclerosis, Disseminated; Shapes; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; T-Cell Activation; T-Cell Receptor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Tissues; Transgenic Model; Trauma, Nervous System; Viral Diseases; Virus Diseases; accessory cell; adult youth; autoimmune disorder; autoimmune encephalomyelitis; base; central nervous system demyelinating disorder; clinical relevance; clinically relevant; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; effective therapy; helper T cell; human disease; immune system tolerance; immune unresponsiveness; immunogen; immunological paralysis; in vivo; insight; insular sclerosis; model organism; nervous system disorder; neurological disease; response; self recognition (immune); thymus derived lymphocyte; viral infection; virus infection; young adult",MECHANISMS OF TOLERANCE AND IMMUNITY TO CENTRAL NERVOUS SYSTEM ANTIGENS,,72737,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,13,379315,
7759163,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI073726-03,,NIAID:381243;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"GOVERMAN, JOAN M;",1866594;,5R01AI073726,02/01/2008,01/31/2013,"APC; ATGN; Address; Adoptive Transfer; Age; Animal Model; Animal Models and Related Studies; Animal Welfare; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Avidity; Bibliography; Binding Determinants; Body Tissues; Brain; Breeding; CNS Diseases; CNS disorder; CTLA-8; CTLA8; Cell Line; Cell Lines, Strains; Cell Mediated Immunology; Cell-Mediated Immunity; CellLine; Cells; Cellular Immunity; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Clinical; Country; Critiques; Cytofluorometry, Flow; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Demyelinating Disease of Central Nervous System; Demyelinating Disorder of Central Nervous System; Demyelinations; Dependence; Disease; Disorder; EAE; ELISPOT; Ecological impact; Encephalomyelitis; Encephalomyelitis, Allergic; Encephalon; Encephalons; Environment; Environmental Impact; Epitopes; Equipment; Ethics Committees, Research; Event; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frequencies (time pattern); Frequency; Gene Expression; Goals; IACUC; IL-17; IL-17A; IL17; IL17 Protein; IL17A; INFLM; IRBs; Immunity, Cellular; Immunization; Immunochemistry; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Impact, Environmental; Incidence; Infiltration; Inflammation; Inflammatory; Inflammatory Infiltrate; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; International; Investigators; Lesion; Light; Literature; Location; MOG glycoprotein; MS (Multiple Sclerosis); Mammals, Mice; Mammals, Rodents; Mediating; Medulla Spinalis; Mice; Microfluorometry, Flow; Modeling; Molecular; Monocytes / Macrophages / APC; Multiple Sclerosis; Murine; Mus; Myelin; Myelin Proteins; Myeloencephalitis; Nervous System, Brain; Nervous System, CNS; Neuraxis; Onset of illness; Patients; Pattern; Photoradiation; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Proliferating; Recombinants; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Rodent; Rodentia; Rodentias; Role; Sclerosis, Disseminated; Sensitization, Immunologic; Sensitization, Immunological; Specificity; Spinal Cord; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Testing; Th-1 Cell; Th1 Cells; Thymus-Dependent Lymphocytes; Tissues; Transgenic Model; Type 1 Helper Cell; Vertebrate Animals; Vertebrates; abstracting; accessory cell; autoimmune encephalomyelitis; base; cell type; central nervous system demyelinating disorder; cultured cell line; disease onset; disease/disorder; disorder onset; enzyme linked immunospot assay; expectation; experience; experiment; experimental research; experimental study; expiration; flow cytophotometry; human disease; human subject; immunogen; improved; insular sclerosis; interest; migration; model organism; myelin oligodendrocyte glycoprotein; oligodendrocyte-myelin glycoprotein; peptide analog; programs; research study; response; social role; substantia alba; thymus derived lymphocyte; trafficking; vertebrata; white matter",MOG-Specific T Cell Trafficking in the Central Nervous System,,73726,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,3,381243,
7750021,R01,AI,5,,01/01/2010,12/31/2010,PA-07-070,5R01AI073737-02,,NIAID:388506;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,NEUROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ZAMVIL, SCOTT S;",1897264;,5R01AI073737,01/01/2009,12/31/2013,"ATGN; Acute; Address; Animal Model; Animal Models and Related Studies; Antibodies; Antigens; Area; Autoimmune Diseases; B blood cells; B cell receptor; B-Cells; B-Lymphocytes; Blood Plasma Cell; Bp35; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD20; CNS autoimmunity; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Chimera; Chimera organism; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cranial Nerve II; Data; Demyelinations; Dendritic Cells; Devic Disease; Devic's Syndrome; Disease model; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Gamma Globulin, 19S; Goals; Human; Human, General; INFLM; IgM; Immune; Immune Globulins; Immune system; Immunoglobulin M; Immunoglobulins; Immunoglobulins / Antibodies; Inflammation; Knock-in; Knock-in Mouse; Leu-16; MHC Receptor; MS (Multiple Sclerosis); MS Lesions; MS4A1; MS4A1 gene; MS4A2; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Membrane; Mice; Modeling; Multiple Sclerosis; Multiple Sclerosis Lesions; Murine; Mus; Myelin; Myeloencephalitis; Nervous System, CNS; Neuraxis; Neuromyelitis Optica; Optic Nerve; Pathogenesis; Peripheral; Plasma Cells; Plasmacytes; Population; Predisposition; Process; Programs (PT); Programs [Publication Type]; Proteins; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Regulation; Relapse; Relative; Relative (related person); Research; Role; Sclerosis, Disseminated; Second Cranial Nerve; Severities; Source; Specificity; Spinal Cord; Staging; Subcellular Process; Susceptibility; T-Cell Receptor; T-Cells; T-Lymphocyte; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Transgenic Organisms; Veiled Cells; autoimmune disorder; autoimmune encephalomyelitis; base; body system, allergic/immunologic; central nervous system autoimmunity; clinical investigation; disorder model; gene product; immunogen; insight; insular sclerosis; interest; membrane structure; model organism; organ system, allergic/immunologic; plasmocyte; programs; public health relevance; response; social role; thymus derived lymphocyte; transgenic",B cells in CNS autoimmunity," PROJECT NARRATIVE B lymphocytes may have multiple roles in the pathogenesis of multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Our studies in experimental autoimmune encephalomyelitis (EAE), the murine MS model, will evaluate and distinguish potentially pathogenic roles of B cells in CNS autoimmunity. Our research program will also evaluate how anti-CD20 B cell depletion, a therapeutic approach being investigated in MS clinical trials, may influence immune regulation. Page 5",73737,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,2,388506,
7776898,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI073858-02,,NIAID:388575;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,SURGERY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"VASU, CHENTHAMARAKSHAN ;",7740247;,5R01AI073858,02/24/2009,01/31/2014,"ATGN; Adopted; Adverse effects; Affinity; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigen Presentation; Antigens; Antiinflammatories; Antiinflammatory Agents; Attention; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmune thyroiditis; Autoimmunity; Autoregulation; B7-1; BB1; Binding; Binding (Molecular Function); Body Tissues; Bone Marrow; CD28; CD28 gene; CD28LG; CD28LG1; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD80; CD80 gene; CDR; CDR Gene; CDR1; CDR1 gene; CDR34; CDR34 Gene; CDR62A; CDR62A Gene; CSIF; CSIF-10; Cell Communication; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell physiology; Cell-to-Cell Interaction; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cerebellar Degeneration-Related Autoantigen 1 Gene; Cerebellar Degeneration-Related Protein (34kD) Gene; Cerebellar Degeneration-Related Protein-1 (34kD) Gene; Cerebellar-Degeneration-Related Antigen 1 Gene; Characteristics; Chronic Lymphocytic Thyroiditis; Clinical; Closure by Ligation; Complementary DNA; Complex; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytokines and Inflammatory Response; DNA, Complementary; Dendritic Cells; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disease model; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Effectiveness; Engineering; Engineerings; Event; Figs; Figs - dietary; Future; Generations; Goals; Graft Rejection; HVEM; Hashimoto Disease; Hashimoto's Disease; Hashimoto's Struma; Hashimoto's Thyroiditis; Hashimoto's syndrome; Hashimotos Disease; Homeostasis; IDD; IDDM; IL-10; IL10; IL10A; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunization; Immunologic Diseases; Immunologic Stimulation; Immunological Diseases; Immunological Stimulation; Immunostimulation; Immunosuppressants; Immunosuppressive Agents; In Vitro; Inbred NOD Mice; Individual; Inflammatory Response Pathway; Insulin-Dependent Diabetes Mellitus; Interleukin 10 Precursor; Interleukin-10; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; LAB7; Lead; Length; Length of Life; Life; Ligands; Ligation; Longevity; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Memory; Methods; Mice; Mice, Inbred NOD; Modeling; Molecular Interaction; Monitor; Mother Cells; Mouse, NOD; Murine; Mus; Nature; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Opportunistic Infections; Orphan; Ovalbumin; Pathway interactions; Pb element; Peptides; Physiologic pulse; Physiological Homeostasis; Process; Progenitor Cells; Property; Property, LOINC Axis 2; Pulse; Receptor Activation; Receptor Protein; Receptors, Antigen, T-Cell; Regulation; Regulatory T-Lymphocyte; Reporting; Rest; Reticuloendothelial System, Bone Marrow; Risk; Role; Safety; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Staging; Stem cells; Subcellular Process; Surface; Synapses; Synaptic; System; System, LOINC Axis 4; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T1 diabetes; T1D; T1DM; T4 Cells; T4 Lymphocytes; T44; Testing; Therapeutic; Therapeutic Effect; Therapeutic Studies; Therapeutic Uses; Therapy Research; Thymus-Dependent Lymphocytes; Thyroglobulin; Thyroiditis, Lymphocytic; Thyroiditis, Lymphomatous; Time; Tissues; Transgenic Organisms; Transplant Rejection; Transplantation Rejection; Treatment Side Effects; Type 1 diabetes; Veiled Cells; Wild Type Mouse; autoimmune disorder; biological signal transduction; cDNA; cell engineering; cellular engineering; cost; cytokine; disease/disorder; disorder model; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; helper T cell; high voltage electron microscopy; immunogen; immunosuppressive; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; insulin dependent diabetes; interest; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; life span; lifespan; mouse model; mutant; overexpression; pathway; prevent; preventing; public health relevance; receptor; receptor expression; research study; response; self recognition (immune); side effect; social role; therapy adverse effect; thymus derived lymphocyte; tool; transgenic; treatment adverse effect; type I diabetes",Dendritic cell directed T cell negative regulation for treating autoimmunity," Project Narrative This project will exploit the professional antigen presenting properties of dendritic cells (DCs) and the powerful inhibitory signals of T cell repressor-receptors (negative regulators) combined to achieve the goal of modulating T cell function and inducing antigen specific T cell hypo-responsiveness and tolerance. This will be achieved by exogenously over-expressing DCs with ligands specific for T cell repressor-receptors (CTLA-4, PD-1 and BTLA) and loading them with the antigen(s) of interest for actively suppressing T cells though delivering inhibitory signals during antigen presentation. Inducing antigen specific T cell tolerance by generating adaptive hypo-responsive and regulatory T cells will be the most effective way of treating autoimmunity and graft rejection and, we believe that, our proposed approach will be one of the most efficient ways of achieving that goal. Moreover, this approach would be one of the efficient ways to study the effect of enhanced engagement of T cell repressor-receptors during antigen presentation. Our study will have an immense impact on approaches to treat autoimmunity without risking opportunistic infections as well as by eliminating the need for a life-long treatment using general immunosuppressive agents.",73858,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,2,388575,
7755386,R01,AI,5,,02/01/2010,01/31/2011,,5R01AI073868-04,,NIAID:366837;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"SMALE, STEPHEN T;",1887605;,5R01AI073868,02/01/2007,01/31/2012,"Activation, Gene; Affinity; Assay; BACs (Chromosomes); Bacterial Artificial Chromosomes; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Bone Marrow; Bp50; CD40; CDW40; Cell Communication and Signaling; Cell Signaling; Cells; Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Chronic; Communicable Diseases; Consensus; DNA; DNA Binding; DNA Binding Interaction; Deoxyribonucleic Acid; Dependence; Dimerization; Disease; Disorder; Edodekin Alfa; Event; Exhibits; Family; Family member; Fusion Protein; Gene Activation; Gene Targeting; Genes; IL-12; IL12; Immune response; Immune system; Immunoglobulin Enhancer-Binding Protein; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammatory; Interleukin-12; Intracellular Communication and Signaling; Investigators; Knowledge; Lead; Learning; MGC9013; Mammals, Mice; Mice; Mice, Transgenic; Molecular Interaction; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; NKSF; Natural Killer Cell Stimulatory Factor; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Pathway interactions; Pb element; Phenotype; Physiologic; Physiological; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Dimerization; Proteins; Publishing; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stimulus; Suggestion; TNFRSF5; TNFRSF5 gene; Targetings, Gene; Testing; Time; Trans-Activation (Genetics); Transactivation; Transcription Activation; Transcription Factor NF-kB; Transcriptional Activation; Transfection; Transgenic Mice; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Up-Regulation; Variant; Variation; base; biological signal transduction; body system, allergic/immunologic; combat; cytokine; dimer; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; host response; immunoresponse; insight; interest; kappa B Enhancer Binding Protein; macrophage; member; new approaches; novel approaches; novel strategies; novel strategy; nuclear factor kappa beta; organ system, allergic/immunologic; p50; p65; pathway; programs; research study; response; social role; success; transcription factor",Selective gene activation by the NF-kappaB family of transcription factors,,73868,CMIA,Cellular and Molecular Immunology - A Study Section,,4,366837,
7759618,R01,AI,5,,02/01/2010,01/31/2011,PA-07-246,5R01AI073911-03,,NIAID:372247;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DAVIS,UNITED STATES,VETERINARY SCIENCES,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"BARTHOLD, STEPHEN WILLIAM (contact);BAUMGARTH, NICOLE ;",1882987 (contact);6871953;,5R01AI073911,02/01/2008,01/31/2013,"A Mouse; Activities of Daily Living; Activities of everyday life; Acute; Address; Affinity; Animal Welfare; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Area; Arthritis; Arthropoda; Arthropods; Assay; B blood cells; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; BRM; Bacteria; Bibliography; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biological Response Modifiers; Biology; Biomodulators; Blood Plasma Cell; Borrelia; Borrelia Infections; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Carditis; Cartoons; Cells; Cells, CD4; Chronic Disease; Chronic Illness; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communicable Diseases, Emerging; Complex; Country; Coupled; Critiques; Cytofluorometry, Flow; Defect; Development; Disease; Disorder; Ecological impact; Editorial Comment; Editorial Comment (PT); Emerging Communicable Diseases; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Europe; FLR; Failure (biologic function); Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Foundations; Future; Gamma Globulin, 19S; Gamma Globulin, 7S; Generalized Growth; Germinal Center; Goals; Growth; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; IACUC; IRBs; IgG; IgM; Immune; Immune Mediators; Immune Mediators/Modulators; Immune Regulators; Immune response; Immunity; Immunocompetent; Immunoglobulin G; Immunoglobulin M; Impact, Environmental; Inducer Cells; Infection; Infectious Diseases / Laboratory; Infectious Diseases Research; Infectious Diseases, Emerging; Influenza Virus; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Knowledge; Lead; Length of Life; Life; Ligand Binding Protein; Location; Longevity; Lyme Borreliosis; Lyme Disease; Lymph node proper; Macrophage Activation; Mammals, Mice; Methods; Mice; Microfluorometry, Flow; Modeling; Murine; Mus; NIH; NIH Program Announcements; National Institutes of Health; National Institutes of Health (U.S.); Nature; Order Spirochaetales; Patients; Pb element; Plasma Cells; Plasmacytes; Principal Investigator; Program Announcement; Programs (PT); Programs [Publication Type]; Published Comment; Publishing; Regulation; Reporting; Research; Research Design; Research Ethics Committees; Research Resources; Resolution; Resources; Reticuloendothelial System, Lymph Node; Solid; Spirochaetales; Spirochetes; Structure; Structure of germinal center of lymph node; Study Type; T-Cell Activation; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Tissue Growth; United States National Institutes of Health; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral Diseases; Virus Diseases; Work; abstracting; antibody biosynthesis; arthritic; base; biodefense; borrelial; borreliosis; chronic disease/disorder; chronic disorder; daily living functionality; disease/disorder; experiment; experimental research; experimental study; expiration; extracellular; failure; flow cytophotometry; functional ability; functional capacity; heavy metal Pb; heavy metal lead; helper T cell; host response; human subject; immunoglobulin biosynthesis; immunoresponse; in vivo; influenzavirus; influenzavirus (unspecified); insight; life span; lifespan; lymph gland; lymph nodes; mouse model; novel; ontogeny; plasmocyte; programs; prophylactic; prototype; research study; response; study design; thymus derived lymphocyte; vertebrata; viral infection; virus infection",Humoral responses to Lyme Borreliosis: A mouse model,,73911,HIBP,Host Interactions with Bacterial Pathogens Study Section,,3,372247,
7763205,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI073947-03,,NIAID:386100;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DURHAM,UNITED STATES,NEUROSCIENCES,04,044387793,US,NC,27705,DUKE UNIVERSITY,"HE, YOU-WEN ;",6716990;,5R01AI073947,03/01/2008,02/28/2013,"Address; Apoptosis; Apoptosis Pathway; Apoptotic; Autoregulation; CAP4 protease; CASP8 Protein; CASP8 and FADD-like apoptosis regulating protein; Cachectin Receptors; Caspase-8/Flice; Casper protein; Cause of Death; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Cleaved cell; Data; Death; Defect; Development; Embryo; Embryonic; Exhibits; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; FLICE-inhibitory protein; FLIP (cellular); Family; Family member; Genetic; Genetic Models; Heart; Homeostasis; Immune response; Immunization; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunologic Stimulation; Immunological Deficiency Syndromes; Immunological Stimulation; Immunostimulation; In Vitro; Individual; Infection; Intracellular Communication and Signaling; Isoforms; Knockout Mice; L. monocytogenes; Listeria monocytogenes; Lymphocyte Biology; MACH protein; Mammals, Mice; Mature T-Cell; Mature T-Lymphocyte; Mch5 protease; Mediating; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Models, Genetic; Murine; Mus; Null Mouse; Organogenesis; Pathway interactions; Peripheral; Physiological Homeostasis; Play; Protein Isoforms; Proteins; Publications; RNA Splicing; RNA, Messenger; Receptor Protein; Receptor Signaling; Regulation; Role; Scientific Publication; Sensitization, Immunologic; Sensitization, Immunological; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Staging; Study Section; Subcellular Process; T-Cell Development; T-Cell Ontogeny; T-Cell Proliferation; T-Cells; T-Lymphocyte; T-Lymphocyte Development; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; Testing; Thymocyte Development; Thymus-Dependent Lymphocytes; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Vaccine Design; base; biological signal transduction; c-FLIP; caspase-8; cleaved; gene product; host response; hypoimmunity; immune deficiency disorder; immunodeficiency; immunoresponse; improved; in vivo; insight; lymphocyte proliferation; mRNA; member; microbial; mouse model; necrocytosis; pathogen; pathway; receptor; social role; thymocyte; thymus derived lymphocyte",Regulation of thymocyte maturation and mature T lymphocyte homeostasis by c-FLIP,,73947,CMIB,Cellular and Molecular Immunology - B Study Section,,3,386100,
7754041,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074233-15,,NIAID:361596;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAMPAIGN,UNITED STATES,CHEMISTRY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"OLDFIELD, ERIC ;",8070727;,5R01AI074233,01/01/1995,01/31/2013,"1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; 8'-Apo-psi,psi-carotenoic acid, 6-O-(12-methyl-1-oxotetradecyl)-alpha-D-glucopyranosyl ester; Active Oxygen; Affect; Anabolism; Animal Welfare; Anti-Bacterial Agents; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antifungal Agents; Antifungal Drug; Area; Azoles; Bacteria; Bibliography; Binding; Binding (Molecular Function); Bisphosphonates; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bone Resorption; Carotenes and Carotenoids; Carotenoids; Cell Wall; Cells; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical; Clinical Data; Clotrimazole; Commit; Communities; Community-Acquired Infections; Computing Methodologies; Country; Crystallographies; Crystallography; D1S1733E; DAN; Defense Mechanisms; Development; Dioxygenases; Diphosphates; Drug Metabolic Detoxication; Drug resistance; Drugs; Ecological impact; Environment; Environmental Impact; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Equipment; Ethics Committees, Research; Formosa; France; Fungicides, Therapeutic; GGDP synthase; GGPP synthase; Gene Expression Profile; Goals; Grant; Guanidine; HOSP; Health; Heterophil Granulocyte; Hospitals; Human; Human, General; Hypercholesteremia; IACUC; IRBs; Immune; Immune system; Immuno-Chemotherapy; Immunochemotherapy; Immunomodulation; Immunomodulators; Immunotherapy, Cancer, General; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; Instruction; International; Killings; Lead; MGC8972; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mediating; Medication; Menaquinone; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Metalloproteins; Methicillin Resistance; Methods; Methods and Techniques; Methods, Other; Mice; Miconazole; Miscellaneous Antibiotic; Mission; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Morphology; Murine; Mus; N03; NBL1; NBL1 gene; NDC-Zoledronate; NO3; Names; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Novartis brand of zoledronic acid; Oranges; Osteoclastic Bone Loss; Osteoporosis; Oxygen Radicals; Pathogenicity Factors; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical condensation; Pigments; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Portugal; Principal Investigator; Pro-Oxidants; Process; Programs (PT); Programs [Publication Type]; Pyrophosphates; QSAR; Quantitative Structure-Activity Relationship; Reactive Oxygen Species; Receptors, Antigen, T-Cell; Republic of China; Research; Research Design; Research Ethics Committees; Research Resources; Resistance; Resources; S. aureus; S.aureus; Spain; Squalene Synthase; Squalene Synthetase; Staphylococcus aureus; Structure; Structure Activity Relationship, Quantitiative; Structure-Activity Relationship; Study Type; System; System, LOINC Axis 4; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; Taiwan; Techniques; Testing; Thymus-Dependent Lymphocytes; Tumor Cell; Vertebrate Animals; Vertebrates; Virulence; Virulence Factors; Virulent; Vitamin K 2; Vitamin K Quinone; Vitamin K2; Work; Zoledronate; Zometa; abstracting; alapha-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate) 6-O-(12-methyltetradecanoate); anti-bacterial; anti-fungal; antibacterial; antifungals; base; biosynthesis; biphosphonate; bisphosphonate; body system, allergic/immunologic; cancer immunotherapy; cell killing; chemical structure function; computational chemistry; computational methodology; computational methods; computational studies; computer methods; computer studies; condensation; conformation; conformational state; cytokine; decaprenyl diphosphate synthase; decaprenyl pyrophosphate synthetase; dehydrosqualene; design; designing; detoxification; di-trans, poly-cis-decaprenylcistransferase; diphosphonate; diphosphoric acid mono(3-methyl-3-butenyl) ester; drug resistant; drug/agent; expiration; farnesyl diphosphate-geranylgeranyl diphosphate synthase; farnesyltransferase; farnesyltranstransferase; gene expression signature; geranylgeranyl pyrophosphatase; geranylgeranyl-diphosphate synthase; guanidinium; heavy metal Pb; heavy metal lead; human subject; hypercholesterolemia; immune modulation; immunologic reactivity control; immunoregulation; inhibitor; inhibitor/antagonist; interest; isopentenyl diphosphate; isopentenyl pyrophosphate; isoprenoid; macrophage; methicillin resistant; neoplastic cell; neutrophil; novel; organ system, allergic/immunologic; pre-clinical; preclinical; programs; protein structure function; psychological defense mechanism; resistance to Drug; resistant; resistant strain; resistant to Drug; response; small molecule; solid state nuclear magnetic resonance; staphyloxanthin; structure function relationship; study design; therapeutic target; thymus derived lymphocyte; transcriptome; undecaprenyl PP synthetase; undecaprenyl diphosphate synthase; undecaprenyl pyrophosphate synthetase; vertebrata","Protein Structure/Function by NMR, Crystallography and Computational Chemistry",,74233,MSFA,Macromolecular Structure and Function A Study Section,,15,361596,
7766184,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074417-03,,NIAID:840757;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"AMARA, RAMA RAO ;",7046286;,5R01AI074417,02/01/2008,01/31/2011,"AIDS/HIV; AIDS/HIV problem; APC; Address; Animal Model; Animal Models and Related Studies; Animal Welfare; Anti-Retroviral Agents; Antibodies; Antigen-Presenting Cells; Antiretroviral Agents; B blood cells; B-Cells; B-Lymphocytes; Bibliography; Blood; Blood Plasma; Blood Serum; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD152 Antigen Gene; CD152 Gene; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CTLA-4 Gene; CTLA4; CTLA4 gene; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cells, CD4; Cellular Immunity; Characteristics; Chronic; Chronic Phase; Country; Critiques; Cytotoxic T-Lymphocyte Protein 4 Gene; Cytotoxic T-Lymphocyte-Associated Antigen 4 Gene; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4 Gene; Data; Death Rate; Dose; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Frequencies (time pattern); Frequency; Goals; HIV/AIDS; HIV/AIDS problem; Human; Human, General; Humoral Immunities; IACUC; IRBs; Immunities, Humoral; Immunity, Cellular; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Accessory Cells; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Impact, Environmental; In Vitro; Infection; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Interruption; Intestinal Mucosa; LCM Viruses; LCMV; LYT3; Laboratories; Ligands; Lymph node proper; Lymphocytic choriomeningitis virus; Macaca; Macaca mulatta; Macaque; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Measures; Mice; Mind; Modeling; Monkeys; Monocytes / Macrophages / APC; Murine; Mus; Pathway interactions; Plasma; Principal Investigator; Programs (PT); Programs [Publication Type]; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Blood; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Serum, Plasma; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; SIV; Safety; Serum; Serum, Plasma; Simian Immunodeficiency Viruses; Site; Suggestion; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Tissue Arrays; Tissue Chip; Tissue Microarray; Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Viremia; Virus; Virus Diseases; Viruses, General; abstracting; accessory cell; anti-retroviral; antibody-based immunity; antiretroviral; base; cell type; experiment; experimental research; experimental study; expiration; falls; helper T cell; human subject; hypoimmunity; immune deficiency disorder; immunodeficiency; improved; in vivo; lymph gland; lymph nodes; meetings; model organism; pathway; programs; receptor; research study; response; restoration; social role; thymus derived lymphocyte; vertebrata; viraemia; viral infection; viral sepsis; virus infection; virusemia",PD-1 blockade as a therapy for SIV/AIDS,,74417,AIP,AIDS Immunology and Pathogenesis Study Section,,3,840757,
7758258,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074420-03,,NIAID:410187;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"CHEN, BENJAMIN K;",7314320;,5R01AI074420,02/01/2008,01/31/2013,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Actins; Adhesion Molecule; Adhesives; Animal Welfare; Antibodies; Antibodies, Blocking; Antibody Formation; Antibody Production; Antibody Response; Antigen Binding Fragment; Antigenic Determinants; Antisera; Assay; Bibliography; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blocking Antibodies; Body Tissues; C-C CKR-5 Gene; C-C Chemokine Receptor Type 5 Gene; CC-CKR-5 Gene; CCCKR5 Gene; CCR-5 Gene; CCR5; CCR5 gene; CD195 Antigen Gene; CD4 Antigen (P55); CD4 Antigens; CD4 Molecule; CD4 Protein; CHEMR13 Gene; CKR-5 Gene; CKR5 Gene; CMKBR5 Gene; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Cell Adhesion; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Density; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell surface; Cells; Cellular Adhesion; Cellular Migration; Cellular biology; Chemokine (C-C) Receptor 5 Gene; Cloning, Molecular; Complement; Complement Proteins; Country; Critiques; Cytofluorometry, Flow; Cytoplasmic Domain; Cytoplasmic Tail; D2S201E; DNA Sequence Rearrangement; Data; Density, Cell; Ecological impact; Endocytosis; Ensure; Environment; Environmental Impact; Epitopes; Equipment; Ethics Committees, Research; Event; Exposure to; Extracellular Matrix, Integrins; FB22; Fab Fragments; Fab Immunoglobulins; Face; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Flushing; Flushings; Gagging; Genetic; Genetic Alteration; Genetic Change; Genetic defect; HIV; HIV Infections; HIV-1; HIV-1 Fusion Co-Receptor Gene; HIV-I; HIV1; HM89; HSY3RR; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hour; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; IACUC; IRBs; Image; Immune Sera; Immunodeficiency Virus Type 1, Human; Immunoglobulin, F(ab) Fragment; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; Integrins; International; Intracellular Communication and Signaling; Investigators; LAP3; LAV-HTLV-III; LCR1; LESTR; Learning; Life; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Measures; Mediating; Membrane Fusion; Microfluorometry, Flow; Molecular Cloning; Monitor; Motility; Motility, Cellular; Mutation; NPY3R; NPYR; NPYRL; NPYY3R; Nature; Nucleic Acids; OKT4 antigen; Pathway interactions; Patients; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Reagent; Rearrangement; Receptors, CD4; Receptors, Surface CD4; Reflex, Pharyngeal; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resistance; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Stream; Structural Protein; Structure; Suggestion; Supporting Cell; Surface; Synapses; Synaptic; T-Cell Antigen T4/Leu3; T-Cell Surface Antigen T4/Leu-3; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T4 molecule; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissues; Transmission; Tripcellim; Trypsin; VESCL; Vaccines; Vertebrate Animals; Vertebrates; Vesicle; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Pathogenesis; Viral Proteins; Virion; Virus; Virus Diseases; Virus Particle; Virus-HIV; Viruses, General; Work; abstracting; antibody biosynthesis; biological signal transduction; cell adhesion protein; cell biology; cell motility; chemotherapy; cross-link; crosslink; experiment; experimental research; experimental study; expiration; facial; flow cytophotometry; genome mutation; helper T lymphocyte marker; human T cell leukemia virus III; human T lymphotropic virus III; human subject; imaging; immunoglobulin biosynthesis; improved; in vivo; inhibitor; inhibitor/antagonist; interest; microbicidal; microbicide; mutant; neutralizing mAb; neutralizing monoclonal antibodies; novel; particle; pathway; polarized cell; polyclonal antibody; programs; research study; resistant; response; social role; synapse formation; synaptogenesis; thymus derived lymphocyte; transmission process; uptake; vaccine development; vertebrata; viral infection; virological synapse; virus infection; virus protein",Mechanisms of highly efficient HIV transfer at virological synapses,,74420,AIP,AIDS Immunology and Pathogenesis Study Section,,3,410187,
7758370,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074554-03,,NIAID:646995;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HONOLULU,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,965088057,US,HI,96822,UNIVERSITY OF HAWAII AT MANOA,"GERSCHENSON, MARIANA ;",6774240;,5R01AI074554,02/01/2008,01/31/2013,"1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine; 2',3'-Didehydro-2',3'-dideoxythmidine; 2',3'-Didehydro-3'-deoxythymidine; 2',3'-Dideoxy-3'-thiacytidine; 2'3' didehydrodeoxythymidine; 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 3'-Deoxy-2'-thymidinene; 3'-azido-2',3'-dideoxythymidine-5'-triphosphate; 3'-azido-3'-deoxythymidine 5'-triphosphate; 3'-deoxy-3'-azidothymidine triphosphate; 3TC; 6H-Dipyrido(3,2-b[{..}]2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-; 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-PMPA; AIDS; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; ATP biosynthesis (oxidative); AZT; AZT (Antiviral); AZT triphosphate; AZT-TP; AZTTP; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adipocytes; Adipose Cell; Adipose tissue; Adverse effects; Affect; Anemia; Animal Welfare; Anti-HIV Positivity; Anti-Retroviral Agents; Antiretroviral Agents; Apoptosis; Apoptosis Pathway; Applications Grants; Arm; Assay; Azidothymidine; Benefits and Risks; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Body Composition; Body Tissues; Body fat; Bone Marrow; Bucca; Buccas; Causality; Cell Death, Programmed; Cell/Tissue, Immunohistochemistry; Cells; Cheek; Cheek structure; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Collaborations; Combined Modality Therapy; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communicable Diseases; Complex; Consent; Country; D-Glucose; D4T; DNA Polymerases; DNA, Mitochondrial; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Data; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Department of Health and Human Services; Department of Health and Human Services (U.S.); Developing Countries; Developing Nations; Development; Dextrose; Didehydrodeoxythymidine; Disease; Disorder; Drug Formulations; Drug Therapy; Drugs; Drugs, Nonproprietary; Dysfunction; EC 2.7.7.7; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Enzymes; Equilibrium; Equipment; Ethics Committees, Research; Etiology; Evaluation; Extremities; Fasting; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Formulation; Formulations, Drug; Functional disorder; Funding; Generic Drugs; Glucose; Grant Proposals; Grants, Applications; H and E; HHS; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; Hawaii; Health; Hematoxylin and Eosin; Hematoxylin and Eosin Staining Method; Histologic; Histologically; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Humulin R; Hyperglyceridemia; Hypertriglyceridemia; IACUC; IHC; IRBs; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; Impact, Environmental; In Situ Nick-End Labeling; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; International; Investigators; Journals; LAV-HTLV-III; Lamivudine; Lead; Less-Developed Countries; Less-Developed Nations; Limb structure; Limbs; Lipids; Lipoatrophy; Lipocytes; Lipodystrophy; Literature; Liver; Lymphadenopathy-Associated Virus; Magazine; Man (Taxonomy); Man, Modern; Markers, Surrogate; Mature Lipocyte; Mature fat cell; Measurement; Measures; Medication; Mitochondria; Mitochondrial DNA; Monitor; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Nevirapine; Non-Trunk; Novolin R; Nucleosides; O element; O2 element; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxidative Stress; Oxygen; PBMC; PNS Diseases; Parents; Pathogenesis; Patients; Pb element; Peripheral Blood Mononuclear Cell; Peripheral Nerve Diseases; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiopathology; Policies; Prevention; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Public Health; Published Comment; Publishing; Punch Biopsy; Raised TG; Raised triglycerides; Randomized; Randomized Clinical Trials; Red Cross; Regimen; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Research Specimen; Research Subjects; Researchers; Residual; Residual state; Resources; Reticuloendothelial System, Bone Marrow; Reverse Transcriptase Inhibitors; Risk; Safety; Serum; Skin; Skinfold Thickness; Specimen; Staining method; Stainings; Stains; Stavudine; Stress; Surrogate Markers; Swab; TUNEL; Tenofovir; Thailand; Therapeutic; Third-World Countries; Third-World Nations; Thymidin; Thymidine; Thymidine, 2',3'-didehydro-3'-deoxy-; Thymidine, 3'-azido-3'-deoxy-; Time; Tissues; Toxic effect; Toxicities; Treatment Period; Treatment Side Effects; Triacylglycerol; Trials, Randomized Clinical; Triglyceride increased; Triglycerides; Triglycerides high; Under-Developed Countries; Under-Developed Nations; United States; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Universities; Upper arm; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viramune; Virus-HIV; Visit; ZDV; ZDV-TP; Zidovudine; abstracting; adipose; analog; anti-retroviral; antibody positive AIDS test; antigen positive AIDS test; antiretroviral; antiretroviral therapy; azidodeoxythymidine; balance; balance function; base; beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine; body system, hepatic; cardiovascular risk; cardiovascular risk factor; clinical investigation; cohort; combination therapy; combined modality treatment; combined treatment; dTTP(3'N3); design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; economic value; elevated tg; elevated triglyceride; emtricitabine; enzyme activity; expiration; fasted; fasts; gene product; generic; heavy metal Pb; heavy metal lead; human subject; insulin resistant; minimally invasive; mitochondrial; mitochondrial dysfunction; monetary value; mtDNA; multimodality therapy; non-human primate; nonhuman primate; novel; open label; organ system, hepatic; oxidative damage; pathophysiology; prevent; preventing; programs; prospective; public health medicine (field); randomisation; randomization; randomly assigned; response; seropositive (AIDS test); side effect; skin fold measurement; skin fold thickness; skinfold measurement; stem; subcutaneous; terminal nick end labeling; therapy adverse effect; tool; treatment adverse effect; treatment days; treatment duration; triphosphate; tripolyphosphate; truvada; vertebrata; white adipose tissue; yellow adipose tissue; zerit; zidovudine triphosphate",Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms,,74554,ZRG1,Special Emphasis Panel,,3,646995,
7758186,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074668-03,,NIAID:310860;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"PFEIFFER, JULIE K;",8736344;,5R01AI074668,02/15/2008,01/31/2013,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Animal Experiments; Animal Welfare; Animals; Antibodies; Assay; Attenuated; Authorization; Authorization documentation; Bibliography; Bioassay; Biohazard; Biohazard Substance; Biohazardous Substance; Biologic Assays; Biological Assay; Biological Models; Blood; Body Tissues; Boxing; Brain; Cell Culture Techniques; Cells; Complex; Country; Critiques; Data; Development; Disease; Disorder; Drug resistance; Ecological impact; Employee; Encephalon; Encephalons; Environment; Environmental Health; Environmental Health Science; Environmental Impact; Epidemic Acute Poliomyelitis; Equipment; Equipment and supply inventories; Ethics Committees, Research; Evolution; Experiments, Animal; Exposure to; Feces; Gastrointestinal Tract, Feces; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Grant; HIV; HTLV-III; Hair; House mice; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human poliovirus; Human, General; IACUC; IFN; IFNAR; IFNAR1; IFNAR1 gene; IRBs; Immune; Impact, Environmental; Infection; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; Interferons; International; Intestinal; Intestines; Inventory; LAV-HTLV-III; LD-50; LD50; Lethal Dose 50; Life; Lymphadenopathy-Associated Virus; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Medical center; Methods; Mice; Model System; Modeling; Models, Biologic; Molecular Biology, Mutagenesis; Murine; Mus; Mus musculus; Mutagenesis; Mutation; Nervous System, Brain; Occupational Health; Oral; Pathogenesis; Permission; Phenotype; Plants; Plants, General; Police; Polio; Polio Virus; Poliomyelitis; Poliomyelitis, Acute; Poliovirus; Poliovirus Vaccines; Polioviruses; Population; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Publishing; RNA Viruses; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Blood; Risk; Role; Safety; Shipping; Ships; Study Type; Texas; Tissues; Transmission; Universities; Vaccination; Vaccine Design; Vaccines; Vertebrate Animals; Vertebrates; Viral; Viral Genome; Viral Vaccines; Virulence; Virulent; Virus; Virus-HIV; Viruses, General; Work; abstracting; animal facility; animal tissue; base; booster vaccine; bowel; design; designing; disease/disorder; drug resistant; experiment; experimental research; experimental study; expiration; face mask; fitness; genome mutation; human subject; in vivo; laser capture microdissection; member; mutant; novel; poliomyelitis vaccine; poliomyelitis virus; prevent; preventing; programs; research study; resistance to Drug; resistant to Drug; social role; stool; study design; transmission process; vector; vertebrata; wasting",The influence of host barriers on viral quasispecies diversity and pathogenesis,,74668,VIRB,Virology - B Study Section,,3,310860,
7762174,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074745-03,,NIAID:332083;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WEST LAFAYETTE,UNITED STATES,VETERINARY SCIENCES,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"KIM, CHANG H;",7650446;,5R01AI074745,02/01/2008,01/31/2013,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 21+ years old; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; AKR/J Mouse; ATGN; ATRA; Acne Vulgaris; Address; Adoptive Transfer; Adult; Agonist; All-Trans-Retinol; All-trans retinoic acid; Animal Model; Animal Models and Related Studies; Animal Welfare; Anti-Infective vitamin; Antibody Formation; Antibody Production; Antibody Response; Antigens; Antixerophthalmic vitamin; Area; Assay; Autoimmune Status; Autoimmunity; Autologous; Axerophthol; Axerophtholum; B blood cells; B-Cells; B-Lymphocytes; Bibliography; Bioassay; Biologic Assays; Biological; Biological Assay; Biosterol; Blood Serum; Blood, Cord; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cancers; Cell Differentiation; Cell Differentiation process; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cells, CD4; Cellular Migration; Cellular biology; Chemopreventive; Chemopreventive Agent; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Data; Development; Diet; Diet Supplement; Dietary Supplements; Disease; Disorder; Dose; Dysplasia; Ecological impact; Editorial Comment; Editorial Comment (PT); Enriched Food; Environment; Environmental Impact; Epithelial; Equipment; Ethics Committees, Research; Food, Fortified; Fortified Food; Gastroenterology; Gastrointestinal Tract, Small Intestine; Generations; Goals; Gut Inflammation; Hand functions; Homing; Homing Behavior; Human; Human, Adult; Human, General; IACUC; INFLM; IRBs; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immune response; Immune system; Immunologic Diseases; Immunological Diseases; Impact, Environmental; In Vitro; Incidence; Inflammation; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intestinal; Intestinal Inflammation; Intestines; Intestines, Small; Investigators; Lamina Propria; Lard-Factor; Lead; Link; Lung; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Modeling; Molecular; Motility; Motility, Cellular; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Nutritional Supplement; Oleovitamin A; Ophthalamin; Pathway interactions; Pb element; Peyer's Patches; Play; Population; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; Receptor Protein; Regulation; Regulatory T-Lymphocyte; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Retinoic Acid; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoid Receptor; Retinoids; Risk; Role; Serum; Site; Small Intestines; Solid; Sorting - Cell Movement; Structure of aggregated lymphoid follicle of small intestine; Study Type; Supplementation; Suppressor Cells; Suppressor-Effector T-Lymphocytes; T Suppressor Cell; T memory cell; T-Cell Subsets; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; T-Lymphocytes, Suppressor-Effector; T4 Cells; T4 Lymphocytes; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissues; Tonsil; Trans Vitamin A Acid; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tretinoin; Tretinoinum; Umbilical Cord Blood; Using hands; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Vitamin A; Vitamin A Acid; Vitamin A Alcohol; Vitamin A Deficiency; Vitamin A USP; Work; abstracting; adult human (21+); all-trans-Retinoic Acid; all-trans-Vitamin A acid; antibody biosynthesis; anticarcinogenic; base; biomarker; body system, allergic/immunologic; bowel; cancer cell; cancer epidemiology; cancer type; cell biology; cell killing; cell motility; clinical applicability; clinical application; disease/disorder; dyscrasia; experience; experiment; experimental research; experimental study; expiration; feeding; fetal cord blood; food consumption; heavy metal Pb; heavy metal lead; helper T cell; host response; human subject; immunogen; immunoglobulin biosynthesis; immunoresponse; in vivo; malignancy; memory T lymphocyte; migration; model organism; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathway; peripheral blood; prevent; preventing; programs; pulmonary; receptor; research study; response; retinol; self recognition (immune); small bowel; social role; sorting; study design; suppressor T lymphocyte; thymus derived lymphocyte; tissue tropism; tonsillar; trafficking; trans-Retinoic Acid; transcription factor; vertebrata",FoxP3+ T cells of mucosal tissues,,74745,III,Innate Immunity and Inflammation Study Section,,3,332083,
7758244,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074856-03,,NIAID:360339;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LAWRENCE,UNITED STATES,BIOLOGY,03,076248616,US,KS,660457568,UNIVERSITY OF KANSAS LAWRENCE,"DE GUZMAN, ROBERTO N;",8166680;,5R01AI074856,02/01/2008,01/31/2013,"Address; Affinity; Animal Welfare; Assay; B. pseudomallei; Bacterial Typing; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biologic Warfare; Biological Assay; Biological Testing; Biological Warfare; Burkholderia pseudomallei; Cells; Chemicals; Complement; Complement Proteins; Complex; Country; Critiques; Data; Dimerization; Disease; Disorder; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fluorescence; Food Poisoning; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Length; Manuscripts; Maps; Methods; Modeling; Molecular Interaction; Needles; P. pseudomallei; P.pseudomallei; Pathogenicity Factors; Polymers; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Dimerization; Proteins; Pseudomonas pseudomallei; Research; Research Ethics Committees; Research Resources; Resources; S. typhimurium; S.typhimurium; Salmonella; Salmonella typhimurium; Sampling; Shapes; Shigella; Solutions; Structure; Surface; Syringes; Testing; Time; Typing, Bacterial; Vertebrate Animals; Vertebrates; Virulence Factors; abstracting; base; biowarfare; design; designing; dimer; disease/disorder; expiration; gene product; human disease; human subject; monomer; mutant; pathogen; programs; protein complex; protein protein interaction; vertebrata",NMR studies of bacterial needle and tip proteins,,74856,MSFC,Macromolecular Structure and Function C Study Section,,3,360339,
7756649,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI074878-03,,NIAID:389813;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"ARTIS, DAVID ;",7858573;,5R01AI074878,02/01/2008,01/31/2013,"Address; Adoptive Transfer; Allergy; Animal Welfare; Animals; Asthma; Automobile Driving; B Cell Differentiation Factor I; B cell activating factor; B cell differentiation factor; B cell growth factor; B cell growth factor 2; B cell stimulating factor 2; B-Cell Differentiation Factor-1; B-Cell Differentiation Factor-2; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Growth Factor-II; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cell Stimulatory Factor-2; BAF; BCDF; BCDF-1; BCGF; BCGF-1; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); BCSF 1; BSF-1; BSF-2; BSF1; BSF1 (B cell stimulating factor 1); BSF2; BSF2 (B cell stimulating factor 2); Bibliography; Binding Sites; Binetrakin; Biological Models; Biology; Breeding; Bronchial Asthma; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTLA-8; CTLA8; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Lineage; Cell Signaling; Cells; Cells, CD4; Chronic; Combining Site; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Critiques; Cytokine Receptors; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; D12S1644; DIF; Data; Development; Differentiation Factor, B-Cell; Disease; Disorder; Drivings, Automobile; EDF; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Eo-CSF; Eosinophil Differentiation Factor; Equipment; Ethics Committees, Research; Event; Family; Family member; Figs; Figs - dietary; Genetic; Goals; Gut Inflammation; HPGF; Helminths; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; Hypersensitivity; IACUC; IFN-beta 2; IFNB2; IL-13; IL-17; IL-17A; IL-17E; IL-23; IL-4; IL-4-STAT; IL-5; IL-6; IL13; IL17; IL17 Protein; IL17A; IL4; IL4 Protein; IL5; IL6 Protein; IRBs; IgA enhancing factor; Immune response; Immunity; Impact, Environmental; In Vitro; Individual; Infection; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin-13; Interleukin-17; Interleukin-4; Interleukin-4 Precursor; Interleukin-5; Interleukin-6; International; Intestinal; Intestinal Inflammation; Intestines; Intracellular Communication and Signaling; Investigators; Literature; Lymphocyte Stimulatory Factor 1; MCGF-2; MGC[{..}]3310; MGI-2; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Measures; Mediating; Memory; Mesenteric; Mesentery; Mice; Model System; Models, Biologic; Molecular; Murine; Mus; Myeloid Differentiation-Inducing Protein; Outcome; Paper; Parasites; Pathway interactions; Pilot Projects; Plasmacytoma Growth Factor; Predisposition; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Published Comment; Reactive Site; Reading; Receptors, Cytokine; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resistance; Resistance to infection; Resources; Rest; Role; STAT6; STAT6 gene; STAT6B; STAT6C; Science of Statistics; Signal Transduction; Signal Transduction Systems; Signaling; Soil; Statistics; Susceptibility; T cell replacing factor; T-Cell Growth Factor 2; T-Cell Replacing Factor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TNF; TNF A; TNF Receptor-Associated Factor 6 Gene; TNF gene; TNFSF2; TRAF6; TRAF6 gene; Testing; Th-2 Cell; Th2 Cells; Therapeutic; Thymus-Dependent Lymphocytes; Trichocephalus; Trichuris; Tumor Necrosis Factor Gene; Type 2 Helper Cell; Ulcerated Colitis; Ulcerative Colitis; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Worms, Parasitic; abstracting; base; biological signal transduction; bowel; cytokine; disease/disorder; driving; experiment; experimental research; experimental study; expiration; field study; helper T cell; high risk; host response; human subject; immunoresponse; in vivo; infection resistance; interferon beta 2; interleukin-17E; interleukin-23; macrophage; member; pathway; pilot study; prevent; preventing; programs; prophylactic; reconstitute; reconstitution; research study; resistant; response; social role; statistics; thymus derived lymphocyte; transcription factor; vertebrata",Functional biology of IL-25 during helminth infection,,74878,PTHE,Pathogenic Eukaryotes Study Section,,3,389813,
7769934,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI074952-02,,NIAID:407633;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,603880287,US,CA,92037,LA JOLLA INST FOR ALLERGY & IMMUNOLGY,"ZAJONC, DIRK M;",8663921;,5R01AI074952,03/01/2009,02/28/2014,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; 1,2-diacylglycerol; 3-D structure; 3-dimensional structure; 3D structure; APC; ATGN; Address; Adjuvant; Amino Acids; Antibodies; Antigen Presentation; Antigen Receptors; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Antigens, CD1; Asialogangliosides; Autoantigens; Autoimmune Diseases; Autoimmune Status; Autoimmunity; Autologous Antigens; B. burgdorferi; B.burgdorferi; Binding; Binding (Molecular Function); Binding Determinants; Biochemical; Biological Models; Biology; Borrelia burgdorferi; Borrelia burgdorferi sensu stricto; Brain; CD1 Antigens; CD1 molecule; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTL; Cell Mediated Immunology; Cell-Mediated Immunity; Cell-Mediated Lympholytic Cells; Cells; Cells, CD4; Cellular Immunity; Ceramide (lipids); Ceramides; Complex; Crystallographies; Crystallography; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; DAG; Data; Development; Diacylglycerols; Diglycerides; Disease; Disorder; Docking; EAE; Encephalomyelitis, Allergic; Encephalon; Encephalons; Epitopes; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Future; Galactocerebrosides; Galactosyl Ceramides; Galactosylceramides; Genes, Class I; Genes, MHC Class I; Genetics-Mutagenesis; Glycerin; Glycerol; Glycolipids; Glycosphingolipids; Goals; Health; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hexoses; Host Defense; Human; Human, General; Hybridomas; Immune; Immune response; Immune system; Immunity, Cellular; Immunologic Accessory Cells; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Inducer Cells; Infection; Infectious Agent; Killings; Kinetic; Kinetics; Light; Link; Lipids; Lyme Borreliosis; Lyme Disease; Lyme Disease Spirochete; Lymphocyte; Lymphocytic; MHC Class I; MHC Class I Genes; MHC Receptor; MS (Multiple Sclerosis); Macromolecular Structure; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mice; Model System; Modeling; Models, Biologic; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Structure; Monocytes / Macrophages / APC; Multiple Sclerosis; Murine; Mus; Mutagenesis; Nervous System, Brain; Order Spirochaetales; Organism; Outcome; Peptides; Phosphatides; Phospholipids; Photoradiation; Play; Production; Property; Property, LOINC Axis 2; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Receptors, Antigen; Receptors, Antigen, T-Cell; Recruitment Activity; Roentgen Rays; Role; Sclerosis, Disseminated; Self-Antigens; Series; Side; Specificity; Sphingoglycolipids; Spinal Column; Spine; Spirochaetales; Spirochetes; Structure; Sulfatides; Sulfatoglycosphingolipids; Sulfoglycosphingolipids; Surface Plasmon Resonance; T-Cell Activation; T-Cell Receptor; T-Cell Receptor Interaction; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TCR Activation; TCR Interaction; Thymus-Dependent Lymphocytes; Type II Cell; Type II Epithelial Receptor Cell; Vertebral column; X-Radiation; X-Rays; Xrays; accessory cell; aminoacid; antigen binding; autoimmune disorder; autoimmune encephalomyelitis; backbone; base; body system, allergic/immunologic; carbene; cell type; chemotherapeutic agent; combat; cytokine; diacylglycerol; diglyceride; disease/disorder; field study; helper T cell; host response; immunogen; immunoresponse; infectious organism; insight; insular sclerosis; interest; lipid structure; living system; lyme spirochete; lymph cell; methylene; methylene radical; microbial; microbial antigen; microorganism antigen; novel; organ system, allergic/immunologic; preference; public health relevance; recruit; response; self recognition (immune); social role; sugar; three dimensional structure; thymus derived lymphocyte; tumor; unsaturated bonds",Structural Immunology of CD1 and CD1-TCR Complexes," PROJECT NARRATIVE NKT cells are specialized lymphocytes that consist of several subtypes and can respond to glycolipids from infectious organisms, such as Borrelia burgdorferi the causative agent of Lyme disease and self-lipids, during the course of autoimmune disease such as Multiple sclerosis. Understanding the functional properties of these cell types at a molecular level is cruical for the future development of novel chemotherapeutic agents or adjuvants to combat both diseases.",74952,CMIA,Cellular and Molecular Immunology - A Study Section,,2,407633,
7754421,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI075038-03,,NIAID:345906;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ALIBERTI, JULIO ;",7839270;,5R01AI075038,02/01/2008,01/31/2013,"5,6,15-tri-HETE; 5,6,15-triHETE; 5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid; 5-Lipoxygenase; Address; Adoptive Transfer; Affect; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arachidonate 5-Lipoxygenase; Arachidonate[{..}]oxygen 5-oxidoreductase; Arachidonic Acid 5-Lipoxygenase; Biochemical; Blood Coagulation Factor IV; Bronchioalveolar Lavage; Bronchoalveolar Lavage; Ca++ element; Calcium; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Cytofluorometry, Flow; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Drugs; Editorial Comment; Editorial Comment (PT); Factor IV; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; GeneHomolog; Grant; Homolog; Homologous Gene; Homologue; Immune; Immune response; Immunity; In Vitro; Infection; Intracellular Communication and Signaling; Ionophores; LTA4 Synthase; LXA4; Lavage, Bronchopulmonary; Left; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase; Linoleate-Oxygen Oxidoreductase; Linoleate[{..}]oxygen 13-oxidoreductase; Lipoxidase; Lipoxins; Lipoxygenase; Lung; Lung Lavage; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Mammals, Mice; Measures; Mediating; Medication; Methods; Mice; Microfluorometry, Flow; Minor; Murine; Mus; Mycobacterium tuberculosis; Ortholog; Orthologous Gene; PPAR alpha; PPARalpha; Pathway interactions; Peroxisome Proliferator-Activated Receptor alpha; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Proteins; Published Comment; Publishing; Regulation; Regulatory Pathway; Resistance; Respiratory System, Lung; Role; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; T-Cells; T-Lymphocyte; T. gondii infection; TXT; Testing; Text; Therapeutic; Thymus-Dependent Lymphocytes; Toxoplasma gondii Infection; Toxoplasmosis; Tuberculosis; Viewpoint; Viewpoint (PT); biological adaptation to stress; biological signal transduction; bronchopulmonary lavage therapy; carotene oxidase; clinical data repository; clinical data warehouse; data repository; disseminated TB; disseminated tuberculosis; drug/agent; experiment; experimental research; experimental study; flow cytophotometry; gene product; host response; immunoresponse; in vivo; lipid mediator; lipoxin A4; macrophage; migration; mouse model; mycobacterial; novel; pathogen; pathway; pulmonary; reaction; crisis; reconstitute; reconstitution; relational database; research study; resistant; social role; stress response; stress; reaction; thymus derived lymphocyte; tuberculous spondyloarthropathy",Control of Immune responses by lipoxins during tuberculosis,,75038,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,3,345906,
7760072,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI075141-03,,NIAID:369765;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MANHASSET,UNITED STATES,,05,110565913,US,NY,11030,FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH,"ROTHSTEIN, THOMAS L;",1875620;,5R01AI075141,02/01/2008,01/31/2013,"2ar peptide; Adoptive Transfer; Allergic Reaction; Animal Welfare; Animals; Anti-DNA Antibodies; Antibodies; Antibodies, Anti-DNA; Antibody Formation; Antibody Production; Antibody Response; Area; Ascaridil; Assay; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Autologous Antigens; Automobile Driving; B blood cells; B cell activating factor; B cell growth factor; B-Cell Activation; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCR Signaling Pathway; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bibliography; Binetrakin; Bioassay; Biologic Assays; Biological Assay; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Signaling; Coloring Agents; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Decaris; Diamond; Disease; Disorder; Drivings, Automobile; Dyes; EAE; EMSA; Ecological impact; Editorial Comment; Editorial Comment (PT); Elements; Employee Strikes; Encephalomyelitis, Allergic; Environment; Environmental Impact; Equipment; Ergamisol; Ergamisole; Eta-1 protein; Eta-1-Op protein; Ethics Committees, Research; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Figs; Figs - dietary; Genetic Polymorphism; Goals; Human; Human, General; IACUC; IL-4; IL4; IL4 Protein; IRBs; Immune; Immunization; Immunol; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Impact, Environmental; In element; Indium; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin-4; Interleukin-4 Precursor; International; Intracellular Communication and Signaling; Ketrax; Kidney; Knock-out; Knockout; Lab Findings; Laboratories; Laboratory Finding; Life; Link; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphocyte Stimulatory Factor 1; MCGF-2; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mast Cell Growth Factor-2; Mediating; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice; Minor; Modeling; Murine; Mus; Paper; Pathology; Pathway interactions; Photometry/Spectrum Analysis, Mass; Play; Polymorphism (Genetics); Polymorphism, Genetic; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteomics; Public Health; Published Comment; Publishing; Readability; Regulatory Element; RegulatoryElement; Research; Research Ethics Committees; Research Resources; Resources; Role; SLE; SLE - Lupus Erythematosus, Systemic; Self-Antigens; Sensitization, Immunologic; Sensitization, Immunological; Serologic; Serological; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solaskil; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stress; Strikes; Strikes, Employee; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T-Cell Activation; T-Cell Growth Factor 2; T-Cells; T-Lymphocyte; TXT; Techniques; Text; Thymus-Dependent Lymphocytes; Tramisol; Trimisol; Urinary System, Kidney; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; anti-dsDNA antibodies; anti-dsDNA antibody; antibody biosynthesis; autoimmune antibody; autoimmune disorder; autoimmune encephalomyelitis; autoreactivity; biological signal transduction; bone sialoprotein 1; bone sialoprotein I; cytokine; design; designing; disease/disorder; disseminated lupus erythematosus; driving; early T-lympocyte activation-1 protein; experiment; experimental research; experimental study; expiration; human disease; human subject; immunoglobulin biosynthesis; improved; osteopontin; overexpression; pathway; phosphoprotein I, 2aR; polymorphism; programs; public health medicine (field); renal; research study; response; secreted phosphoprotein 1; self reactive antibody; self recognition (immune); septic; sialoprotein 1; social role; systemic lupus erythematosis; thymus derived lymphocyte; transcription factor; vertebrata",An Alternate Pathway to Autoimmunity,,75141,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,3,369765,
7758279,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI075157-03,,NIAID:409613;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"CRAFT, JOSEPH ;",1870629;,5R01AI075157,02/01/2008,01/31/2013,"Animal Welfare; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Process; Autologous Antigens; Autoregulation; B blood cells; B-Cells; B-Lymphocytes; Bibliography; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Causality; Cells; Cells, CD4; Chronic; Co-Stimulator; Costimulator; Country; Development; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Epidermal Thymocyte Activating Factor; Equipment; Ethics Committees, Research; Etiology; Homeostasis; Human; Human, General; IACUC; IL-15; IL-2; IL15; IL15 Protein; IL2; IL2 Protein; IRBs; Immune; Immune response; Impact, Environmental; Inflammatory; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-15; Interleukin-15 Precursor; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; International; LYT3; Left; Logic; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphocyte; Lymphocyte Mitogenic Factor; Lymphocytic; Lytotoxicity; MGC9721; MHC Receptor; Major Histocompatibility Complex Receptor; Man (Taxonomy); Man, Modern; Mediating; Memory; Mitogenic Factor; Pathologic; Patients; Peripheral; Physiological Homeostasis; Play; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Receptors, Antigen, T-Cell; Research; Research Ethics Committees; Research Resources; Resources; Role; SLE; SLE - Lupus Erythematosus, Systemic; Self-Antigens; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T cell growth factor; T-Cell Growth Factor; T-Cell Proliferation; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Tissues; To autoantigen; Vertebrate Animals; Vertebrates; abstracting; autoimmune antibody; cytokine; cytotoxicity; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; disseminated lupus erythematosus; expiration; helper T cell; host response; human subject; immunoresponse; lymph cell; programs; response; self reactive antibody; social role; systemic lupus erythematosis; thymus derived lymphocyte; vertebrata",Dissecting the role for IL-15 in CD8+ T cell homeostasis in human lupus,,75157,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,3,409613,
7760527,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI075192-03,,NIAID:377760;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PORTLAND,UNITED STATES,BIOCHEMISTRY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"ULLMAN, BUDDY ;",1866208;,5R01AI075192,02/15/2008,01/31/2013,"3-D structure; 3-dimensional structure; 3D structure; 5'-AMP Deaminase; AIDS; AMP Aminase; AMP Aminohydrolase; AMP Deaminase; ATP[{..}]adenosine 5'-phosphotransferase; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Adenosine Kinase; Adenylate Deaminase; Applications Grants; Assay; Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological; Biological Assay; Biosynthetic Proteins; C. parvum; Categories; Cell Culture Techniques; Cells; Cellular biology; Chemicals; Chemistry, Biological; Cryptosporidiosis; Cryptosporidium parvum; DISSEC; DNA Molecular Biology; Development; Disease; Disorder; Dissection; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; E coli; ELIG; Eligibility; Eligibility Determination; Enzymes; Escherichia coli; Fluorescence; GMP synthase; GMP synthetase; Genes; Genetic; Genome; Genomics; Goals; Grant Proposals; Grants, Applications; High Throughput Assay; Human; Human, General; Immunologic Deficiency Syndrome, Acquired; Infection; Intention; Investigation; Kinetic; Kinetics; Knock-out; Knockout; Lesion; Ligase; Man (Taxonomy); Man, Modern; Medication; Models, Molecular; Molecular; Molecular Biology; Molecular Models; Mutate; Myoadenylate Deaminase; NIAID; National Institute of Allergy and Infectious Disease; Nucleic Acid Biochemistry, Molecular Modeling; Nucleosides; Nutritional; Opportunistic Infections; Organism; Parasites; Parasitic Diseases; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Protocol Screening; Purine Nucleotides; Purines; R01 Mechanism; R01 Program; RPG; Reaction; Reagent; Recombinant Proteins; Recombinants; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Role; S cerevisiae; Saccharomyces cerevisiae; Scheme; Selection (Genetics); Structure; Structure-Activity Relationship; Substrate Specificity; Synthetases; T. gondii; Technology; Testing; Therapeutic; Toxoplasma gondii; Transgenic Organisms; Vaccines; Validation; Yeast, Baker's; Yeast, Brewer's; adenylic acid deaminase; base; biodefense; cell biology; chemical structure function; chemotherapy; disease/disorder; drug discovery; drug/agent; enzyme structure; gene function; gene product; guanylate; high throughput screening; in vivo; inhibitor; inhibitor/antagonist; kinase inhibitor; living system; molecular modeling; mutant; novel; nucleobase analog; nucleoside analog; overexpression; pathogen; pathway; purine; purine analog; repository; social role; structural biology; structure function relationship; therapeutic target; three dimensional structure; tool; transgenic; waterborne; weapons",Purine Salvage Pathway of Cryptosporidium Parvum,,75192,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,3,377760,
7770783,R01,AI,5,,02/10/2010,01/31/2011,PA-07-070,5R01AI076066-03,,NIAID:484854;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BETTS, MICHAEL R;",1958430;,5R01AI076066,02/01/2008,01/31/2013,"AIDS Virus; Access to Information; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Adenoviridae; Adenoviruses; Animal Welfare; Antigenic Determinants; Assay; Bibliography; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; Canada; Case Study; Cell Count; Cell Function; Cell Number; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chronic; Chronic Phase; Clinic; Collaborations; Collection; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Cryofixation; Cryopreservation; Data; Development; Disease Progression; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Epitopes; Equipment; Ethics Committees, Research; Evaluation; Event; Freezing; Funding; Future; Genes, Class I; Genes, MHC Class I; Genetic Alteration; Genetic Change; Genetic defect; Goals; HIV; HIV Infections; HIV vaccine; HIV/AIDS Vaccines; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Heterogeneity; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IACUC; IRBs; Immune; Immune response; Immune system; Immunologic Monitoring; Immunosurveillance; Impact, Environmental; In Vitro; Individual; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; K22 Award; Knowledge; LAV-HTLV-III; LYT3; Letters; Lymphadenopathy-Associated Virus; MHC Class I; MHC Class I Genes; Maps; Measures; Modeling; Monitor; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; Mutation; Pattern; Phase; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; Recovery; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Resources; Resolution; Resources; Role; Sample Size; Sampling; Site; Staining method; Stainings; Stains; Study Type; Subcellular Process; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; T8 Cells; T8 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Time; Vaccinated; Vaccination; Variant; Variation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral; Virus-HIV; Writing; abstracting; body system, allergic/immunologic; case report; cohort; cold preservation; cold storage; comparative; disease control; disorder control; expiration; fighting; genome mutation; host response; human immunodeficiency virus vaccine; human study; human subject; immunoresponse; in vivo; novel; organ system, allergic/immunologic; outreach to information; programs; protective effect; recruit; response; social role; study design; thymus derived lymphocyte; vaccine candidate; vaccine development; vertebrata",T Cell Functionality and Control of Acute HIV Infection,,76066,VACC,HIV/AIDS Vaccines Study Section,,3,484854,
7756619,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076104-03,,NIAID:378201;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"CUSHION, MELANIE T;",1888157;,5R01AI076104,02/01/2008,01/31/2012,"A549; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Affect; Animal Welfare; Antirejection Therapy; Assay; Bibliography; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Function; Biological Process; Biology; Cell Nucleus; Cells; Chrysemonas; Common Rat Strains; Communication; Country; Custom; Cyst; Data; Diff-Quik Staining Method; Diff-quik Stain; Doctor of Philosophy; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Expression Profiling; Expression Signature; Flavimonas; Gene Expression; Gene Products, RNA; Generalized Growth; Genes; Glucans; Glucose Polymer; Goals; Growth; IACUC; IRBs; ITX; Immune system; Immunologic Deficiency Syndrome, Acquired; Immunologically Directed Therapy; Immunosuppressive Therapy; Immunotherapy; Impact, Environmental; In Vitro; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kinetic; Kinetics; Lead; Letters; Life Cycle; Life Cycle Stages; Lung; Mammals, Mice; Mammals, Rats; Measurement; Medicine; Methods; Mice; Microarray Analysis; Microarray-Based Analysis; Microbe; Microbial Biofilms; Microscopic; Mind; Modeling; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Morphology; Motion; Murine; Mus; Nucleus; Organism; Outcome; P. carinii; P.carinii; Pansy; Pathogenicity; Patients; Pb element; Persons; Ph.D.; PhD; Pneumocystis; Pneumocystis carini; Pneumocystis carinii; Pneumonia; Pneumonitis; Polyglucoses; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Proteins; Pseudomonas; Pulmonary Alveoli; Pulmonary Inflammation; Pulmonary alveolar structure; RNA; RNA, Non-Polyadenylated; Rat; Rattus; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Respiratory System, Lung; Ribonucleic Acid; Science of Medicine; Staining method; Stainings; Stains; Structure; System; System, LOINC Axis 4; TXT; Testing; Text; Therapeutic immunosuppression; Therapy, Anti-Rejection; Time; Tissue Growth; Validation; Vertebrate Animals; Vertebrates; Viola; Violet; abstracting; artificial immunosuppression; assault; beta-Glucans; biofilm; body system, allergic/immunologic; candida biofilm; college; expiration; fungus; gene product; glucan synthase; heavy metal Pb; heavy metal lead; human subject; immune therapy; immunosuppression; in vivo; inhibitor; inhibitor/antagonist; interest; life course; living system; lung alveolus; member; microarray technology; molecuar profile; molecular signature; monolayer; novel; ontogeny; organ system, allergic/immunologic; programs; pulmonary; tool; treatment effect; vertebrata; willingness",Biofilm Formation by Pneumocystis,,76104,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,3,378201,
7761211,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076170-03,,NIAID:839486;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,PHARMACOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HU, SHIU-LOK ;",1862821;,5R01AI076170,02/01/2008,01/31/2012,"AIDS; AIDS Virus; ATGN; Abscission; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Animal Welfare; Animals; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Antigens; Arm; Bibliography; Binding Determinants; Common Epitope; Country; Development; Disease; Disorder; Ecological impact; Envelope Glycoprotein gp120, HIV; Envelope Protein; Environment; Environmental Impact; Epitopes; Equipment; Ethics Committees, Research; Excision; Extirpation; FLR; Failure (biologic function); Gene Products, env; Glycans; Goals; HIV; HIV Envelope Protein gp120; HIV-1; HIV-I; HIV1; HTLV-III; HTLV-III gp120; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; IACUC; IRBs; Immune response; Immunization; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; LAV-HTLV-III; Laboratories; Link; Lymphadenopathy-Associated Virus; Macaca; Macaque; Mediating; Modeling; Modification; Nature; Phenotype; Polysaccharides; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Regimen; Removal; Research; Research Ethics Committees; Research Resources; Resources; Role; SHIV; Sensitization, Immunologic; Sensitization, Immunological; Structure; Surgical Removal; Upper arm; Vaccines; Vertebrate Animals; Vertebrates; Viral Diseases; Virus; Virus Diseases; Virus-HIV; Viruses, General; abstracting; antibody biosynthesis; base; cost; design; designing; disease/disorder; env Antigens; env Gene Products; env Polyproteins; env Protein; env Protein gp120, HIV; expiration; failure; gp120; gp120 ENV Glycoprotein; gp120(HIV); host response; human T cell leukemia virus III; human T lymphotropic virus III; human subject; immunogen; immunogenic; immunogenicity; immunoglobulin biosynthesis; immunoresponse; interest; mutant; neutralizing antibody; neutralizing mAb; neutralizing monoclonal antibodies; novel; programs; protective efficacy; resection; simian HIV; simian human immunodeficiency virus; social role; success; vertebrata; viral infection; virus infection","Glycan modification, CD4 independence, and Env immunogenicity",,76170,VACC,HIV/AIDS Vaccines Study Section,,3,839486,
7760542,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076231-13,,NIAID:374378;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"EISENBERG, ROSELYN J;",1903906;,5R01AI076231,02/01/2008,01/31/2013,"Animal Welfare; Arts; Assay; Back; Bibliography; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biosensor; Caring; Cell fusion; Cells; Cellular Membrane; Chemicals; Cold Sore; Combining Site; Confocal Microscopy; Country; Coupled; DNA Viruses; Data; Dorsum; Ecological impact; Encephalitis; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; FRET; Fever Blister; Fluorescence Resonance Energy Transfer; GeneHomolog; Glycoproteins; Grant; HSV; Herpes Labialis; Herpes Simplex Virus; Herpes Simplex, Labial; Herpes labialis Virus; Herpesviridae; Herpesvirus hominis; Herpesviruses; Homolog; Homologous Gene; Homologue; IACUC; IRBs; Impact, Environmental; Individual; Inflammation, Brain; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Laboratories; Life; Lipids; Liposomal; Liposomes; Methods and Techniques; Methods, Other; Microscopy, Confocal; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Movement; Optics; Phenotype; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; Quartz; Quartz (SiO2); Reactive Site; Receptor Cell; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Role; Simplexvirus; Solutions; Stream; Structure; Techniques; Technology; Time; Vertebrate Animals; Vertebrates; Viral; Virion; Virus; Virus Particle; Viruses, General; Visual; Work; abstracting; base; body movement; experiment; experimental research; experimental study; expiration; gene product; herpes febrilis; herpes virus; herpesvirus; human disease; human herpesvirus 1 group; human subject; improved; innovate; innovation; innovative; interest; mutant; new approaches; new therapeutic target; novel approaches; novel strategies; novel strategy; programs; protein complex; receptor; receptor binding; research study; sensor (biological); social role; vertebrata",Early Events in Herpes Simplex Virus Entry,,76231,VIRA,Virology - A Study Section,,13,374378,
7763925,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076257-02,,NIAID:389813;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SCOTT, PHILLIP A.;",1895737;,5R01AI076257,02/15/2009,01/31/2014,"ATGN; Antigens; C57BL/6 Mouse; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Chronic Disease; Chronic Illness; DNA; Data; Dendritic Cells; Dendritic cell activation; Deoxyribonucleic Acid; Development; Disease; Disorder; Edodekin Alfa; Ensure; Event; Exhibits; FLR; Failure (biologic function); Foundations; HTRPY; Healed; Health; Human; Human, General; Hypertrophy; IL-12; IL12; ITX; Immune response; Immunity; Immunologic, Immunochemical; Immunologically Directed Therapy; Immunologics; Immunosuppressants; Immunosuppressive Agents; Immunotherapeutic agent; Immunotherapy; Individual; Infection; Interleukin-12; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Leishmania; Leishmania (Leishmania) mexicana; Leishmania (genus); Leishmania mexicana; Leishmaniasis; Lesion; Ligands; Lymph node proper; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Morbidity; Morbidity - disease rate; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Parasites; Pb element; Physiologic; Physiological; Play; Predisposition; Production; Protozoan Infections; Resistance; Resolution; Reticuloendothelial System, Lymph Node; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subcellular Process; Susceptibility; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Th-1 Cell; Th1 Cells; Therapeutic; Thymus-Dependent Lymphocytes; Translating; Translatings; Type 1 Helper Cell; Veiled Cells; base; biological signal transduction; chronic disease/disorder; chronic disorder; cytokine; design; designing; disease/disorder; experiment; experimental research; experimental study; failure; healing; heavy metal Pb; heavy metal lead; helper T cell; host response; immune therapy; immunogen; immunologic preparation; immunoresponse; immunosuppressive; immunotherapeutics; interventional strategy; language translation; lymph gland; lymph nodes; protozoal infection; public health relevance; research study; resistant; response; social role; thymus derived lymphocyte",Initiation of Immune Response in Chronic Leishmaniasis," Leishmaniasis is a chronic protozoal infection causing severe morbidity worldwide. Experimental infections of mice with Leishmania mexicana are used to define the immunologic responses responsible for an inability to cure these infections. In this proposal, the inability of L. mexicana to induce lymph node expansion is examined, in an effort to design new immunotherapeutic approaches to curing this disease.",76257,PTHE,Pathogenic Eukaryotes Study Section,,2,389813,
7767711,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076276-02,,NIAID:394250;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"LLINAS, MANUEL ;",8769238;,5R01AI076276,02/15/2009,01/31/2014,"AP-2; AP-2 Alpha; AP-2 Alpha Protein; AP2; AP2 Protein; AP2 Transcription Factor; AP2TF Protein; Activating Enhancer-Binding Protein 2-Alpha; Activator Protein 2; Active Transport, Cell Nucleus; Affect; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemistry; Biologic Assays; Biological Assay; Blood erythrocyte; Blood normocyte; CHIP assay; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cessation of life; ChIP (chromatin immunoprecipitation); Chemistry, Biological; Clinical; Collection; Combining Site; Complex; Confocal Microscopy; Culicidae; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA Molecular Biology; DNA-Binding Proteins; DNA-Protein Interaction; Data; Death; Deoxyribonucleic Acid; Detection; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug resistance; Environment; Erythrocytes; Erythrocytic; Euchromatin; Eukaryota; Eukaryote; Evolution; Exhibits; Family; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Transcription; Genome; Goals; Growth; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hour; Human; Human, General; In Vitro; Individual; Infection; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knock-out; Knockout; Libraries; Ligands; Liver Cells; Malaria; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Measures; Methods; Microscopy, Confocal; Modeling; Modification; Molecular; Molecular Biology; Molecular Interaction; Mosquitoes; NLS Peptide; Nuclear; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Nuclear Transport; Nucleocytoplasmic Shuttling; Nucleus; Oligo; Oligonucleotides; Organism; Paludism; Parasites; Pattern; Peptide Domain; Peptides; Phase; Plants; Plants, General; Plasmids; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Protein Domains; Protein Dynamics; Protein Motifs, DNA-Binding; Proteins; RNA Expression; Reactive Site; Recombinants; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Research; Reticuloendothelial System, Erythrocytes; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Staging; TFAP2 Protein; TFAP2A; TFAP2A Protein; TFAP2alpha protein; Tertiary Protein Structure; Time; Tissue Growth; Transcript; Transcription; Transcription Factor AP-2 Alpha; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Work; base; biological signal transduction; blood corpuscles; chromatin immunoprecipitation; disease/disorder; drug resistant; eukaryotida; functional genomics; gene product; in vivo; interventional strategy; living system; novel; novel therapeutic intervention; nucleocytoplasmic transport; ontogeny; plant development; plant growth; plant growth/development; public health relevance; resistance to Drug; resistant to Drug; social role; tool; transcription factor; transcription factor AP-2 alpha protein; transcription factor AP-2alpha",Regulation of Plasmodium falciparum transcription," Relevance. Malaria is a major worldwide disease caused by the Plasmodium parasite with over half a billion cases annually. With the sharp rise in drug-resistant parasites, the challenge is to identify and characterize novel drug targets for anti-malarial strategies. Our research plan will investigate the mechanisms underlying the regulation of gene expression during parasite development as a potential avenue for new therapeutic interventions.",76276,PTHE,Pathogenic Eukaryotes Study Section,,2,394250,
7763201,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076322-04,,NIAID:367043;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,AUSTIN,UNITED STATES,BIOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"TRENT, MICHAEL STEPHEN;",6276602;,5R01AI076322,02/01/2008,01/31/2013,"ATGN; Acute; Antigens; Area; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial resistant; Categories; Cell Membrane Permeability; Cholera; Complex; Developing Countries; Developing Nations; Development; Disease; Disorder; Environment; Food; Gastrointestinal Tract, Small Intestine; Generalized Growth; Glycans; Gram-Negative Bacteria; Growth; Health; Human; Human, General; Hydrogen Oxide; Immune; Immunologic Receptors; Immunological Receptors; Intestines, Small; LPS; Less-Developed Countries; Less-Developed Nations; Life; Lipid A; Lipopolysaccharides; Man (Taxonomy); Man, Modern; Mediating; Membrane; Modification; Monitor; Names; O Antigen, Bacterial; O Antigens; O-Specific Polysaccharides; Oligosaccharides; Pathway interactions; Polysaccharides; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Receptors, Immunologic; Regulation; Research; Small Intestines; Structure; Surface; TLR protein; Third-World Countries; Third-World Nations; Tissue Growth; Toll-like receptors; Under-Developed Countries; Under-Developed Nations; V. cholerae; V.cholerae; Vaccines; Vibrio cholerae; Vibrio comma; Water; antimicrobial peptide; bacterial resistance; disease/disorder; extracellular; immune receptor; immunogen; improved; membrane permeability; membrane structure; novel; ontogeny; overgrowth bacterial; pandemic; pandemic disease; pathogen; pathogenic bacteria; pathway; programs; resistance to Bacteria; resistance to Bacterial; resistant to Bacteria; resistant to Bacterial; response; small bowel",The Outer Surface of Vibrio cholerae,,76322,BACP,Bacterial Pathogenesis Study Section,,4,367043,
7760132,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076372-02,,NIAID:459800;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOLOGY,08,001423631,US,MA,02115,NORTHEASTERN UNIVERSITY,"LEWIS, KIM ;",2423455;,5R01AI076372,02/01/2009,01/31/2014,"1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 2-Methyl-5-nitroimidazole-1-ethanol; ABCB1; ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; Absorption; Acute; Address; Anaerobic Bacteria; Animal Testing; Animals; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bacteria; Bacteria, Anaerobic; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; Berberine; Biology; C elegans; C. difficile; C.difficile; C.elegans; Caenorhabditis elegans; Cells; Chemistry, Pharmaceutical; Clinical; Clinical Trials, Phase I; Clostridium difficile; Collaborations; Computer Simulation; Computerized Models; Coupled; Cricetinae; Development; Diarrhea; Dose; Drug resistance; E. faecalis; E.faecalis; Early-Stage Clinical Trials; Enterococcus faecalis; Family; Flagyl; GeneHomolog; Generalized Growth; Goals; Golden Seal; Goldenseal; Gram-Positive Bacteria; Growth; Hamsters; High Throughput Assay; Homolog; Homologous Gene; Homologue; Human; Human, General; Hybrids; Hydrastis canadensis; In Vitro; Incidence; Infection; Intestinal; Intestines; Killings; Lead; Libraries; Lytotoxicity; MDR1 Protein; Mammalia; Mammals; Mammals, General; Mammals, Hamsters; Mammals, Mice; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Medicinal Chemistry; Medicinal Plants; Metro I.V.; Metronidazole; Mice; Miscellaneous Antibiotic; Modeling; Models, Computer; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; Murine; Mus; Organism; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein Transporter; P-Glycoproteins; PGY-1 Protein; Pb element; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Plants, Medicinal; Population; Probability; Process of absorption; Property; Property, LOINC Axis 2; Pump; Relapse; Reproduction spores; Research; Resistance; Resistance development; Resistant development; Risk; S. faecalis; S.faecalis; Satric; Simulation, Computer based; Site; Spores; Staging; Streptococcus Group D; Streptococcus faecalis; Testing; Therapeutic; Tissue Growth; Toxic effect; Toxicities; Umbellatine; Validation; Vancomycin; Veterinary Medicine; Virulent; Work; absorption; anaerobe; anti-microbial; antimicrobial; bactericidal; bactericide; base; bowel; cell killing; chemotherapy; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cross reactivity; cytotoxicity; developing resistance; drug development; drug discovery; drug resistant; efflux pump; feeding; gastrointestinal infection; heavy metal Pb; heavy metal lead; high throughput screening; in silico; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; living system; mouse model; multidisciplinary; novel; ontogeny; pathogen; phase 1 study; phase 1 trial; phase I trial; prevent; preventing; protocol, phase I; public health relevance; resistance mechanism; resistance to Drug; resistant; resistant mechanism; resistant to Drug; virtual simulation",A synergy-based therapy against C. difficile," Project narrative  Clostridium difficile is the most commonly recognized cause of antibiotic-associated diarrhea (AAD).  We will develop an effective therapeutic against drug-resistant C. difficile by disabling the mechanism of resistance to berberine, a widely used antimicrobial from medicinal plants.",76372,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,459800,
7772311,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076395-02,,NIAID:370013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"MULLEN, HELEN B;",1881286;,5R01AI076395,02/20/2009,01/31/2013,"21+ years old; APC; ATGN; Address; Adult; Animal Model; Animal Models and Related Studies; Antigen Presentation; Antigen-Presenting Cells; Antigens; Autoantibodies; Autoantigens; Autoimmune Diseases; Autoimmune thyroiditis; Autologous Antigens; B blood cells; B-Cells; B-Lymphocytes; Birth; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C2B8 Monoclonal Antibody; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chimera; Chimera organism; Chronic Lymphocytic Thyroiditis; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Dendritic Cells; Development; Disease; Disease remission; Disorder; Drugs; Effector Cell; Eragrostis; Goals; Head and Neck, Thyroid; Human, Adult; Hydrogen Oxide; IL-10; IL10; IL10A; Immunologic Accessory Cells; Infiltration; Injection of therapeutic agent; Injections; Interleukin 10 Precursor; Interleukin-10; Knowledge; LYT3; Mammals, Mice; Medication; Mice; Modeling; Monocytes / Macrophages / APC; Murine; Mus; Parturition; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Production; Public Health; RMSN; Regulatory T-Lymphocyte; Remission; Residual; Residual state; Resistance; Reticuloendothelial System, Bone Marrow; Rituximab (C2B8 Antibody); Role; Self-Antigens; Severities; Subcellular Process; T-Cell Activation; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; Teff; Testing; Thymus-Dependent Lymphocytes; Thyroglobulin; Thyroid; Thyroid Gland; Thyroiditis, Lymphocytic; Thyroiditis, Lymphomatous; Time; To autoantigen; Veiled Cells; Water; Wild Type Mouse; Work; accessory cell; adult human (21+); autoimmune antibody; autoimmune disorder; autoreactive T cell; design; designing; disease/disorder; drinking water; drug/agent; experiment; experimental research; experimental study; immunogen; in vivo; insight; macrophage; man; man's; model organism; new approaches; novel approaches; novel strategies; novel strategy; public health medicine (field); public health relevance; research study; resistant; rituximab; self reactive antibody; social role; thymus derived lymphocyte; uptake",Mechanisms by which B cell depletion inhibits autoimmune diseases," Relevance to Public Health: Drugs such as Rituximab that selectively deplete B cells are currently used to treat several autoimmune diseases in man. Although these drugs are very effective, there are large gaps in knowledge of the mechanisms by which B cell depletion inhibits autoimmune diseases, primarily because versions of the drugs able to deplete B cells in animal models were not available until recently. Our studies use a well characterized animal model of autoimmune disease to test the hypothesis that one mechanism of inhibition of autoimmune disease following B cell depletion involves activation of a subset of T cells called regulatory T cells that function to suppress autoimmune diseases. These studies will also determine if disease remission is maintained after the drug is stopped and B cells have returned, or if continued injections of the drug are required to maintain disease remission.",76395,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,2,370013,
7754694,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076456-03,,NIAID:373725;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"BRYCE, PAUL J;",8155361;,5R01AI076456,02/01/2008,01/31/2013,"1H-Imidazole-4-ethanamine; ATGN; Acute; Address; Adoptive Transfer; Allergens; Allergic; Allergic inflammation; Allergy; Animal Welfare; Antigens; Antihistamines; Asthma; Autoimmune; Autoimmune Process; BRM; Basophilic Histiocyte; Basophils, Tissue; Bibliography; Binding; Binding (Molecular Function); Biological Response Modifiers; Biology; Biomodulators; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; Bronchial Asthma; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chemoattractants; Chemotactic Factors; Chemotaxins; Chronic Hepatitis; Collaborations; Country; Cytokines, Chemotactic; Cytoplasmic Granules; Delayed Hypersensitivity; Delayed-Type Hypersensitivity; Dendritic Cells; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Graft Rejection; Health; Hepatitis, Chronic; Heterophil Granulocyte; Histamine; Histamine Liberation; Histamine Receptor; Histamine Release; Homologous Chemotactic Cytokines; Hypersensitivity; IACUC; IDD; IDDM; INFLM; IRBs; IgE; Immigrations; Immune; Immune Mediators; Immune Mediators/Modulators; Immune Regulators; Immunity; Immunoglobulin E; Impact, Environmental; In Vitro; In-Migration; Infection; Inflammation; Inflammatory Response; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Intercrines; International; Intracellular Communication and Signaling; Investigation; Investigators; Link; Lung; Lymphoid; Mammals, Mice; Marrow Mast Cell; Marrow Neutrophil; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Modeling; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Names; Neuronal Injury; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Receptor Protein; Recombinants; Recruitment Activity; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Rest; Role; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Source; System; System, LOINC Axis 4; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T1 diabetes; T1D; T1DM; Testing; Thymus-Dependent Lymphocytes; Tissues; Transplant Rejection; Transplantation Rejection; Tuberculin-Type Hypersensitivity; Type 1 diabetes; Type IV Hypersensitivity; Veiled Cells; Vertebrate Animals; Vertebrates; Work; abstracting; airway epithelium infalmmation; airway inflammation; allergic airway disease; allergic response; antigen challenge; base; biological signal transduction; cell mediated hypersensitivity; cell motility; cell type; chemoattractant cytokine; chemokine; chemokine receptor; complement chemotactic factor; cooking; cytokine; delayed-type hypersensitivity response; disease/disorder; expiration; granule; human subject; immunogen; in vivo; inhibitor; inhibitor/antagonist; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; mast cell; mastocyte; migration; neuron injury; neutrophil; novel; prevent; preventing; programs; pulmonary; receptor; reconstitute; reconstitution; recruit; response; social role; thymus derived lymphocyte; trafficking; tumor; type I diabetes; vertebrata",Regulation of T cell migration by histamine,,76456,ZRG1,Special Emphasis Panel,,3,373725,
7756658,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI076458-03,,NIAID:382568;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"REINER, STEVEN L;",1868059;,5R01AI076458,02/01/2008,01/31/2013,"ATGN; Address; Animal Welfare; Antigens; Area; Bibliography; CD8; CD8B; CD8B1; CD8B1 gene; Cell Polarity; Cell division; Cells; Collagen Peptidase; Collagen-Degrading Enzyme; Communicable Diseases; Country; Data; Daughter; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Equipment; Esteroproteases; Ethics Committees, Research; Exhibits; Figs; Figs - dietary; Future; Hereditary; Heterogeneity; Host Defense; IACUC; IRBs; Image; Immune response; Immunity; Impact, Environmental; In Situ; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; International; L. monocytogenes; LCM Viruses; LCMV; LYT3; Listeria monocytogenes; Lymph node proper; Lymphocyte; Lymphocytic; Lymphocytic choriomeningitis virus; Manuals; Mediating; Memory; Methods; Methods and Techniques; Methods, Other; Microbe; Microscopy; Modification; Outcome; Parents; Peptidases; Peptide Hydrolases; Photons; Play; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Spleen; Reticuloendothelial System, Thymus; Role; Signaling Protein; Sorting - Cell Movement; Spleen; Suggestion; T-Cells; T-Lymphocyte; T. gondii; Techniques; Testing; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Toxoplasma gondii; Tubulin; Uncertainty; Vaccines; Vertebrate Animals; Vertebrates; Virus; Viruses, General; Work; abstracting; base; beta Tubulin; biodefense; cell fate specification; cell stroma; cellular polarity; collagenase; daughter cell; dispase; doubt; experience; experiment; experimental research; experimental study; expiration; gene product; host response; human subject; imaging; immunogen; immunoresponse; improved; in vivo; lymph cell; lymph gland; lymph nodes; pathogen; programs; research study; response; retroviral transduction; social role; sorting; thymus derived lymphocyte; vertebrata",Asymmetric CD8+ T Cell Division in the Initiation of Immunity,,76458,CMIB,Cellular and Molecular Immunology - B Study Section,,3,382568,
7763208,R01,AI,5,,02/01/2010,01/31/2011,PA-07-320,5R01AI076471-02,,NIAID:381645;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"LUO, HONGBO R;",8134454;,5R01AI076471,02/06/2009,01/31/2013,"3,4,5-PIP3; 47KDa platelet protein; Assay; Bacteria; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Calcium Ion Signaling; Calcium Signaling; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell membrane; CellLine; Cells; Cellular biology; Cessation of life; Chemicals; Chemistry; Chemoattractants; Chemotactic Factors; Chemotaxins; Chemotaxis; Cytoplasm; Cytoplasmic Membrane; Cytosol; Data; Death; Development; Drug Evaluation, Preclinical; Drug Screening; Enhancers; Evaluation; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Event; Funding; Future; GFP; GeneHomolog; Genetic Screening; Goals; Green Fluorescent Proteins; Guidelines; HL-60 Cells; HL60 Cells; Heterophil Granulocyte; High Throughput Assay; Homolog; Homologous Gene; Homologue; Host Defense; Immune; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Infection; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Institutes; Intracellular Communication and Signaling; Invaded; Killings; Lead; Leukocytes; Life; Marrow Neutrophil; Marrow leukocyte; Mediating; Membrane; Methods; Microorganisms, General; Molecular Interaction; NIH Program Announcements; Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; PH Domain; Pathway interactions; Pb element; Phagocytosis; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphorylation; Plasma Membrane; Pleckstrin-Homology Domain; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Preclinical Drug Evaluation; Process; Production; Program Announcement; Protein Phosphorylation; Protein translocation; PtdIns; PtdIns(3,4,5)P3; Reproducibility; Research; Reticuloendothelial System, Leukocytes; Schools, Medical; Science of Chemistry; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Superoxide Anion; Superoxide Radical; Superoxides; System; System, LOINC Axis 4; Transmembrane Protein Transport; White Blood Cells; White Cell; Writing; assay development; base; biological signal transduction; cell biology; cell type; chemical genetics; complement chemotactic factor; cultured cell line; drug development; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; high throughput screening; in vivo; medical schools; membrane structure; microorganism; neutrophil; novel; pathogen; pathway; phosphatidylinositol 3,4,5-triphosphate; phosphatidylinositol 3,4,5-trisphosphate; plasmalemma; platelet 47k protein; platelet protein P47; pleckstrin; public health relevance; research study; screening; screenings; small molecule; small molecule libraries; white blood cell; white blood corpuscle",HTS for enhancers of neutrophil function that specifically augment PIP3 signal," Project Narrative The ultimate goal of our research is to identify PtdIns(3,4,5)P3 pathway activators that specifically target PH domain plasma membrane translocation via performing a high throughput screening of small molecule libraries. Discovery of these activators will greatly facilitate our research on PtdIns(3,4,5)P3 signaling in neutrophil function and innate immunity. Moreover, the identified activators can be directly utilized as starting chemical compounds for novel immune enhancer drug development, particularly for severe infections due to lack of enough pathogen killing capability.",76471,ISD,Instrumentation and Systems Development Study Section,,2,381645,
7751278,R01,AI,5,,01/01/2010,12/31/2010,PA-07-070,5R01AI076852-03,,NIAID:468914;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"MANCHESTER, MARIANNE ;YOUNG, JOHN A T (contact);",1865266;6452824 (contact);,5R01AI076852,01/01/2008,12/31/2012,"ATGN; Address; Animal Welfare; Anthrax; Anthrax disease; Antibodies; Antibody Binding Sites; Antigens; Antitoxins; B. anthracis; Bacillus anthracis; Bacteria; Bibliography; Binding; Binding (Molecular Function); Binding Sites, Antibody; Categories; Country; Development; Disease; Disorder; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Names; Paratopes; Pathogenesis; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Receptor Protein; Reproduction spores; Research; Research Ethics Committees; Research Resources; Resources; Role; Spores; Therapeutic; Toxin; Vaccines; Vertebrate Animals; Vertebrates; abstracting; anthracis; anthrax toxin; antibody combining site; base; disease/disorder; expiration; human subject; immunogen; inhibitor; inhibitor/antagonist; next generation; programs; receptor; receptor binding; social role; vertebrata",Receptor Decoy Inhibitor of Anthrax Toxin,,76852,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,3,468914,
7760563,R01,AI,5,,02/01/2010,01/31/2011,PA-07-320,5R01AI077457-03,,NIAID:690696;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"KUTSCH, OLAF ;",7557808;,5R01AI077457,02/15/2008,01/31/2011,"AIDS Virus; AIDS therapy; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adverse effects; Affect; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Bioassay; Biologic Assays; Biological Assay; Calcineurin; Cell Density; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemicals; Chemistry, Pharmaceutical; Cytofluorometry, Flow; DNA Methylation; Data; Density, Cell; Development; Diversity Library; Drug Delivery; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening; Drug Targeting; Drug Targetings; Drug toxicity; Drugs; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Event; FK 506; FK506; Face; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Gene Transcription; Genetic Transcription; Goals; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Half-Life; Half-Lifes; Histone Deacetylation; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Infection; Intention; LAV-HTLV-III; Laboratories; Lead; Light; Lymphadenopathy-Associated Virus; Magic; Maintenance; Maintenances; Measures; Medication; Medicinal Chemistry; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Nature; PP2B; Patients; Pattern; Pb element; Performance; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Photoradiation; Play; Population; Preclinical Drug Evaluation; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphatase-2B; RNA Expression; Regimen; Reporter; Research; Robotics; Role; Series; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Tacrolimus; Techniques; Therapeutic; Thymus-Dependent Lymphocytes; Time; Transcription; Transcription, Genetic; Treatment Side Effects; Viral; Virus-HIV; antiretroviral therapy; base; cultured cell line; design; designing; drug/agent; facial; flow cytophotometry; heavy metal Pb; heavy metal lead; histone modification; human T cell leukemia virus III; human T lymphotropic virus III; inhibitor; inhibitor/antagonist; insight; latent infection; new therapeutic target; novel; prevent; preventing; programs; side effect; small molecule; social role; therapy adverse effect; thymus derived lymphocyte; treatment adverse effect",HTS for inhibitors of HIV-1 latency establishement,,77457,ADDT,AIDS Discovery and Development of Therapeutics Study Section,,3,690696,
7760121,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI077460-03,,NIAID:371250;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,NEUROSCIENCES,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"WHITE, MARTYN K;",1959744;,5R01AI077460,02/01/2008,01/31/2013,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Animal Welfare; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Assay; Astrocytes; Astrocytus; Astroglia; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bacteria; Bibliography; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Brain; Brain Diseases; Brain Disorders; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; CellLine; Cells; Childhood; Chronic; Combining Site; Country; Critiques; Cytokine Signal Transduction; Cytokine Signaling; Cytoplasm; DNA, Viral; Data; Demyelinating Diseases; Demyelinating Disorders; Development; Differentiation Factor, B-Cell; Ecological impact; Ectopic Expression; Encephalitis, JC Polyomavirus; Encephalon; Encephalon Diseases; Encephalons; Environment; Environmental Impact; Equilibrium; Equipment; Ethics Committees, Research; Figs; Figs - dietary; FuGene; FuGene 6; GFP; Gene Expression; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Green Fluorescent Proteins; HIV-1; HIV-I; HIV1; HPGF; Hepatocyte-Stimulating Factor; Human; Human Polyomavirus JC; Human immunodeficiency virus 1; Human, General; Hybridoma Growth Factor; IACUC; IFN-beta 2; IFNB2; IL-6; IL6 Protein; IRBs; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Impact, Environmental; Infection; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 6 (Interferon, Beta 2); Interleukin-6; International; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Isoforms; JC Polyomavirus Encephalopathy; JC Virus; Length; Leukoencephalopathy, Progressive Multifocal; Life Cycle; Life Cycle Stages; Limulus factor C; Lip; Lip structure; Lipids; Literature; Lytic Cycle; Lytic Infection; Lytic Phase; MGI-2; Man (Taxonomy); Man, Modern; Manufacturer; Manufacturer Name; Messenger RNA; Molecular; Molecular Interaction; Monitor; Mutation; Myelin; Myeloid Differentiation-Inducing Protein; NCCR; National Coalition for Cancer Research; Natural immunosuppression; Nervous System, Brain; Nucleic Acid Regulatory Sequences; Nucleus; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Phospho-Specific Antibodies; Phosphopeptide-Specific Antibodies; Phosphorylation; Phosphorylation Site; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Plasmacytoma Growth Factor; Plasmids; Polyoma; Polyoma Viruses; Polyomavirus; Polyomavirus hominis 2; Polyomavirus, JC; Population; Prevalence; Principal Investigator; Programs (PT); Programs [Publication Type]; Progressive Multifocal Leukoencephalopathy; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Protein Phosphorylation; Protocol; Protocols documentation; RNA Expression; RNA, Messenger; Reactive Site; Reagent; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Relative; Relative (related person); Reporter; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Study Type; Time; Toxic effect; Toxicities; Trans-Acting Factors; Trans-Activators; Transactivators; Transcription; Transcription, Genetic; Transfection; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Latency; Viral Proteins; Virus Diseases; Virus Latency; Virus Replication; abstracting; adeno vector; adenovector; balance; balance function; base; biological signal transduction; cultured cell line; cytokine; experiment; experimental analysis; experimental research; experimental study; expiration; factor C; fetal; genetic regulatory element; genome mutation; horseshoe crab factor C; human T cell leukemia virus III; human T lymphotropic virus III; human subject; immunosuppression; interferon beta 2; life course; mRNA; neurotropic; oligodendroglioma; oligofectamine; pediatric; programs; protein expression; research study; response; social role; study design; trans acting factor (genetic); transcription factor; vertebrata; viral DNA; viral infection; virus DNA; virus infection; virus multiplication; virus protein",Cytokine regulation of JC virus latency and reactivation,,77460,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,3,371250,
7755373,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI077607-03,,NIAID:469013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"WHITTON, J. LINDSAY;",1882848;,5R01AI077607,02/01/2008,01/31/2013,"4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-; APC receptor; ATGN; Acute; Adoptive Transfer; Affect; Animal Welfare; Anti-Viral Response; Antibodies; Antigens; Antigens, Viral; Antimetabolites; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Apoptosis; Apoptosis Inhibitor 3; Apoptosis Pathway; Ascotoxin; Au element; Autocrine Systems; BIRC4; BIRC4 protein, human; Back; Baculoviral IAP Repeat-Containing Protein 4; Bibliography; Biological; Body Tissues; Brefeldin A; CD127 Antigens; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; Caspase Inhibitor; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell-Death Protease; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Color; Contracting Opportunities; Contracts; Country; Cyanein; Cytotoxic cell; DNA; DNA Vaccines; Data; Decumbin; Deoxyribonucleic Acid; Detection; Disadvantaged; Dorsum; Drops; Ecological impact; Electronics; Endocrine; Ensure; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Experimental Models; Experimental Models, Other; Feedback; Gene Expression; Generations; Genes; Goals; Gold; IACUC; IAP-Like Protein; ICE-like protease; IL7 Receptors; IRBs; Immunity; Immunization; Immunocompetent; Immunodeficient Mouse; Immunologic Stimulation; Immunological Stimulation; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Impact, Environmental; In Vitro; Infection; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 7 Receptor; Interleukin 7 Receptor Alpha; International; Intracellular Communication and Signaling; Investigators; K lymphocyte; Kinetic; Kinetics; LCM Viruses; LCMV; LYT3; Laboratories; Link; Literature; Lymphocytic choriomeningitis virus; Mammals, Mice; Mediating; Memory; Methods; Methods and Techniques; Methods, Other; Mice; Modeling; Models, Experimental; Murine; Mus; NK Cells; Naked DNA Vaccines; Names; Natural Killer Cells; Normal Cell; Phase; Phenotype; Physiologic pulse; Play; Population; Position; Positioning Attribute; Principal Investigator; Printing; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; Publishing; Pulse; Qualifying; Reading; Reagent; Receptor Protein; Receptors, IL-7; Recombinants; Recurrence; Recurrent; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Residual; Residual state; Resources; Role; Science; Scientific Publication; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Somatic Cell; Sorting - Cell Movement; Source; Subcellular Process; Survivors; Synergisidin; System; System, LOINC Axis 4; T memory cell; T-Cell Activation; T-Cell Proliferation; T-Cells; T-Lymphocyte; T8 Cells; T8 Lymphocytes; Techniques; Testing; Thymus-Dependent Lymphocytes; Time; Tissues; Transgenic Organisms; Vaccination; Vaccines; Vaccines, DNA; Vaccines, Recombinant DNA; Vertebrate Animals; Vertebrates; Viral Antigens; Viral Diseases; Virus; Virus Diseases; Viruses, General; Wheat; Work; X-linked Inhibitor of Apoptosis; abstracting; activated protein C receptor; autocrine; baculoviral IAP repeat-containing protein-4, human; biological signal transduction; caspase; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; endothelial cell protein C receptor; exhaust; experience; experiment; experimental research; experimental study; expiration; feeding; human BIRC4 protein; human subject; immunogen; in vivo; memory T lymphocyte; new approaches; novel approaches; novel strategies; novel strategy; paracrine; programs; receptor; receptor expression; research study; response; social role; sorting; thymus derived lymphocyte; transgenic; vertebrata; viral infection; virus antigen; virus infection",Understanding and manipulating the T cell contraction phase,,77607,IHD,Immunity and Host Defense Study Section,,3,469013,
7766985,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI077613-02,,NIAID:381843;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"SPERANDIO, VANESSA ;",7032630;,5R01AI077613,02/13/2009,01/31/2014,"Adhesions; Alimentary Canal; Applications Grants; Bacteria; Bovine Species; Cattle; Cell Communication and Signaling; Cell Signaling; Cells; Cessation of life; Consumption; Dairy Products; Death; Detection; Diarrhea; Diet; Digestive Tract; Disease Outbreaks; E coli; EHEC; EHEC, Escherichia coli; Enterocytes; Enterohemorrhagic E coli; Enterohemorrhagic E. coli; Enterohemorrhagic E.coli; Enterohemorrhagic Escherichia coli; Enterohemorrhagic strain of E coli; Enterohemorrhagic strain of E. coli; Enterohemorrhagic strain of Escherichia coli; Environment; Epithelial Cells; Escherichia coli; Escherichia coli EHEC; GI Tract; Gasser's Syndrome; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Genes; Genetic Transcription; Genetics-Mutagenesis; Grant Proposals; Grants, Applications; HOSP; Health; Hemolytic-Uremic Syndrome; Homolog; Homologous Gene; Homologue; Hospitalization; Human; Human, General; Infection; Intestinal; Intestines; Intracellular Communication and Signaling; Kidney Failure; Kidney Insufficiency; Large Intestine; Lesion; Liquid substance; Man (Taxonomy); Man, Modern; Meat; Mediating; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Names; Outbreaks; Pathogenicity Island; RNA Expression; Receptor Protein; Regulation; Renal Failure; Renal Insufficiency; Reporting; Research; Role; Rumen; STEC; Sampling; Serotyping; Shiga toxin-producing E coli; Shiga toxin-producing E. coli; Shiga toxin-producing E.coli; Shiga toxin-producing Escherichia coli; Signal Transduction; Signal Transduction Systems; Signaling; Transcription; Transcription, Genetic; United States; Virulence; alimentary tract; attenuation; base; biological signal transduction; bovid; bovine; bowel; cow; digestive canal; economic cost; fluid; food born pathogen; food borne pathogen; foodborn pathogen; foodborne pathogen; homoserine lactone; interest; large bowel; liquid; mutant; public health relevance; quorum sensing; receptor; small molecule; social role; transcription factor",SdiA regulation of EHEC virulence," Project Narrative: Enterohemorrhagic E.coli (EHEC) serotype O157:H7 is the agent responsible for outbreaks of bloody diarrhea throughout the world. The main reservoir for EHEC is cattle herds. Consequently, diminishing cattle colonization and shedding of EHEC is of great interest to human health. In this grant proposal, we aim to understand how a signaling mechanism between bacterial cells through a small molecule called acyl-homoserine lactone, which is present in the rumen of cattle, controls expression of EHEC genes necessary for virulence and colonization of the bovine intestine.",77613,BACP,Bacterial Pathogenesis Study Section,,2,381843,
7758189,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI077726-03,,NIAID:380880;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BLACKSBURG,UNITED STATES,ZOOLOGY,09,003137015,US,VA,24060,VIRGINIA POLYTECHNIC INST AND ST UNIV,"MYLES, KEVIN M;",8457847;,5R01AI077726,02/01/2008,01/31/2013,"Acute; Address; Aedes; Aedes (genus); Alpha Virus; Alphavirus; Animal Welfare; Anopheles; Anopheles Genus; Anti-Viral Response; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Arboviral infections; Arbovirus Infections; Arboviruses; Arboviruses, Group A; Arthropod-Born Viral Infection; Arthropod-Borne Viruses; Arthropoda; Arthropods; Bibliography; Biological; Blood; Body Tissues; Breakbone Fever Virus; Cells; Codon; Codon Nucleotides; Codon, Sense; Codon, Stop; Codon, Termination; Codon, Terminator; Competence; Country; Culicidae; Data; Dengue Virus; Diagnostic; Disease; Disease Vectors; Disorder; Double-Stranded RNA; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Epidemiology; Equipment; Ethics Committees, Research; Flavivirus Infections; Genes; Genome; Genomics; Glare; Goals; IACUC; IRBs; Immune; Immune response; Immunomodulation; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Link; Maintenance; Maintenances; Modeling; Mosquitoes; Names; Nature; Nonstructural Protein; ORFs; Open Reading Frames; Pathway interactions; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pressure; Pressure- physical agent; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Coding Region; Protein, Nonstructural; Public Health; Quelling; RNA Interference; RNA Interference Pathway; RNA Silencing; RNA Silencings; RNA Viruses; RNA polymerase III transcription; RNA, Double-Stranded; RNA, Viral; RNAi; Research; Research Ethics Committees; Research Resources; Resistance; Resources; Reticuloendothelial System, Blood; Role; Sense Codon; Sequence-Specific Posttranscriptional Gene Silencing; Stop Signal, Translation; System; System, LOINC Axis 4; Temperature; Terminator Codon; Time; Tissues; Transgenic Organisms; Transmission; Vector (Infectious Agent); Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Virus; Virus Diseases; Virus Replication; Viruses, General; abstracting; base; design; designing; disease control; disease/disorder; disorder control; dsRNA; expiration; feeding; fitness; host response; human subject; immune modulation; immunologic reactivity control; immunoregulation; immunoresponse; pathogen; pathway; pressure; programs; public health medicine (field); resistant; response; social role; transgenic; transmission process; vector; vector mosquito; vertebrata; viral RNA; viral infection; virus RNA; virus infection; virus multiplication",Modulation of arboviruses in mosquitoes,,77726,VB,Vector Biology Study Section,,3,380880,
7765515,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078138-02,,NIAID:386100;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEWARK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"LUKAC, DAVID M;",1927835;,5R01AI078138,02/15/2009,01/31/2014,"Affinity Chromatography; Amino Acids; Animal Viruses; Architecture; Assay; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Burkitt Herpesvirus; Burkitt Lymphoma Virus; CHIP assay; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Chromatography, Affinity; Combining Site; Complex; DNA; DNA Binding; DNA Binding Interaction; DNA Sequence; DNA Viruses; DNA-Binding Proteins; DNA-Protein Interaction; Data; Deoxyribonucleic Acid; Diagnostic; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E-B Virus; EB virus; EBV; EMSA; Elements; Engineering / Architecture; Enhancers; Epstein Barr Virus; Epstein-Barr Virus; Gene Expression Profile; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Goals; HHV-4; HHV-8; HHV8; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Human; Human Herpesvirus 4; Human Pathology; Human, General; Hybridization Array; Hybrids; In Vitro; Infection; Infectious Mononucleosis Virus; Intracellular Communication and Signaling; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Ligand Binding Protein; Light; Lytic; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Mutation; Notch Signaling Pathway; Oligonucleotide Array; Oligonucleotide Microarrays; Pathway interactions; Photometry/Spectrum Analysis, Mass; Photoradiation; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Proteins; Proteolysis and Signaling Pathway of Notch; Reactive Site; Regulation; Reporter; Repressor Proteins; Role; Scientific Advances and Accomplishments; Screening procedure; Series; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Targetings, Gene; Trans-Activation (Genetics); Transactivation; Transcription Activation; Transcriptional Activation; Up-Regulation; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus-HHV8; Viruses, Animal; Viruses, General; Yeasts; affinity purification; aminoacid; base; biological signal transduction; cell growth; chromatin immunoprecipitation; disease/disorder; experiment; experimental research; experimental study; gene expression signature; gene product; genome mutation; genome-wide; human herpesvirus 4 group; human herpesvirus 8; in vivo; mutant; notch; notch protein; notch receptors; novel; pathway; public health relevance; research study; response; scientific accomplishments; scientific advances; screening; screenings; social role; tissue culture; transcription factor; transcriptome; virus host interaction; virus protein",Re-specification of the Notch response by the HHV-8 lytic switch protein," Project Narrative  This project will advance scientific understanding of the mechanisms by which Human herpesvirus-8 (HHV- 8) interacts with Humans to cause disease. Specifically, the experiments will reveal mechanisms by which the key viral protein Rta re-specifies the target genes stimulated by a cellular signaling pathway that has been associated with Human pathologies. Unique drug targets and diagnostic markers may be revealed.",78138,VIRB,Virology - B Study Section,,2,386100,
7755427,R01,AI,5,,02/01/2010,01/31/2011,PA-07-320,5R01AI078288-03,,NIAID:469013;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"TOBIAS, PETER S;",1885075;,5R01AI078288,02/15/2008,01/31/2011,"Adverse effects; Analgesia Tests; Animal Welfare; Assay; Autoimmune Status; Autoimmunity; Autopsy; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood monocyte; Body Tissues; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Chimera; Chimera organism; Country; Detection; Drugs; EAE; Ecological impact; Encephalomyelitis, Allergic; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Evolution; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; HeLa; Hela Cells; Heterophil Granulocyte; High Throughput Assay; IACUC; IRBs; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Impact, Environmental; In Vitro; Infection; Inflammatory Response; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Ischemia-Reperfusion Injury; Lactamase; Lead; Libraries; Marrow Neutrophil; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Methods; NIH; Names; National Institutes of Health; National Institutes of Health (U.S.); Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nociception Tests; Pain Assessment; Pain Measurement; Pathogen detection; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Programs (PT); Programs [Publication Type]; Reperfusion Damage; Reperfusion Injury; Research; Research Ethics Committees; Research Resources; Resource Sharing; Resources; Screening procedure; Septic Shock; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Sterility; TIL4; TLR protein; TLR2; TLR2 gene; TLR4; TLR4 gene; TOLL; Therapeutic; Time; Tissues; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Treatment Side Effects; Uncertainty; United States National Institutes of Health; Vertebrate Animals; Vertebrates; Work; abstracting; autoimmune encephalomyelitis; base; biological signal transduction; cardiovascular disorder; cell type; detector; doubt; drug development; drug/agent; expiration; hToll; heavy metal Pb; heavy metal lead; high throughput screening; host response; human subject; immunoresponse; in vivo; inhibitor; inhibitor/antagonist; kidney ischemia; macrophage; monocyte; necropsy; neutrophil; pathogen; postmortem; programs; renal ischemia; response; screening; screenings; self recognition (immune); side effect; stable cell line; sterile; therapy adverse effect; treatment adverse effect; vertebrata",HIGH THROUGHPUT SCREENING FOR TOLL-LIKE RECEPTORS INHIBITORS,,78288,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,3,469013,
7762238,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078289-03,,NIAID:471032;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,FARMINGTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"LEFRANCOIS, LEO ;",1881250;,5R01AI078289,02/15/2008,01/31/2013,"Anatomic; Anatomical Sciences; Anatomy; Animal Welfare; Automobile Driving; Autoregulation; Bibliography; CD11c; CD8; CD8B; CD8B1; CD8B1 gene; Confocal Microscopy; Country; Data; Dendritic Cells; Development; Drivings, Automobile; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Extracellular Matrix, Integrins; Genes, Class I; Genes, MHC Class I; Homeostasis; IACUC; IRBs; ITGAX; ITGAX gene; Immune response; Immune system; Impact, Environmental; In Situ; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; Integrins; International; L. monocytogenes; LYT3; Listeria monocytogenes; Lymphocyte; Lymphocytic; MHC Class I; MHC Class I Genes; Mammals, Mice; Memory; Mice; Mice, Transgenic; Microscopy, Confocal; Movement; Murine; Mus; Names; Physiological Homeostasis; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Reporter; Research; Research Ethics Committees; Research Resources; Resources; Role; Science of Anatomy; Series; Staining method; Stainings; Stains; Stream; Sum; T-Cell Activation; T-Cells; T-Lymphocyte; Testing; Thymus-Dependent Lymphocytes; Transgenic Mice; Veiled Cells; Vertebrate Animals; Vertebrates; Viral Diseases; Virus Diseases; abstracting; anatomy; body movement; body system, allergic/immunologic; driving; expiration; gene product; host response; human subject; immunoresponse; in vivo; lymph cell; organ system, allergic/immunologic; programs; response; social role; thymus derived lymphocyte; vertebrata; viral infection; virus infection",Role of CD11c in CD8 T cell response to infection,,78289,IHD,Immunity and Host Defense Study Section,,3,471032,
7760033,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078426-03,,NIAID:383625;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,SURGERY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"NEWELL, KENNETH A;",1916577;,5R01AI078426,02/15/2008,01/31/2013,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acute; Address; Alloantigen; Allogenic; Allografting; Animal Model; Animal Models and Related Studies; Animals; Antigens, Viral; Antiviral Agents; Antiviral Drugs; Antivirals; BK Virus; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; CMV; Cells; Characteristics; Chronic; Clinical; Clinical, Transplantation, Organ; Complement; Complement Proteins; Cytomegalovirus; Cytopathic Effect, Viral; Cytopathogenic Effect, Viral; Development; Donor, Organ; Drugs; Dysfunction; Environment; Environmental Exposure; Epithelial Cells; Experimental Models; Experimental Models, Other; Exposure to; FLR; Failure (biologic function); Family; Functional disorder; Genes, Class I; Genes, MHC Class I; Grafting Procedure; Grafting, Kidney; HCMV; Human; Human Polyomavirus BK; Human, General; INFLM; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunocompetent; Immunologic Deficiency Syndrome, Acquired; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Injury; Ischemia-Reperfusion Injury; Kidney; Kidney Diseases; Kidney Transplantation; Kidney Transplants; LYT3; Lead; MHC Class I; MHC Class I Genes; MMF; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Modeling; Models, Experimental; Murine; Mus; Mycophenolate Mofetil (Cellcept); Natural Immunity; Natural immunosuppression; Nature; Nephropathy; Organ; Organ Donor; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Pathogenesis; Pathology; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Polyoma; Polyoma Viruses; Polyomaviridae; Polyomavirus; Polyomavirus Infections; Polyomavirus hominis 1; Polyomavirus, BK; Prevalence; Process; Renal Disease; Renal Transplantation; Renal Transplants; Reperfusion Damage; Reperfusion Injury; Reporting; Resolution; Route; Salivary Gland Viruses; Source; Species Specificity; T-Cells; T-Lymphocyte; Tacrolimus; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Tissues; Transmission; Transplant Recipients; Transplantation; Transplantation Surgery; Urinary System, Kidney; Urinary tract; Viral; Viral Antigens; Viral Cytopathogenic Effect; Viral Diseases; Viremia; Virus; Virus Activation; Virus Diseases; Virus Induction; Viruses, General; base; clinical relevance; clinically relevant; cytomegalovirus group; drug/agent; effective intervention; effective therapy; failure; graft function; heavy metal Pb; heavy metal lead; host response; human cytomegalovirus; immunopathology; immunoresponse; immunosuppression; immunosuppressive; improved; kidney allograft; kidney disorder; model organism; mouse model; mouse polyomavirus; murine polyomavirus; mycophenolate mofetil; mycophenolic acid morpholinoethyl ester; novel therapeutic intervention; organ allograft; organ graft; organ xenograft; pathogen; pathophysiology; prevent; preventing; public health relevance; renal; renal allograft; renal disorder; response; thymus derived lymphocyte; tool; transmission process; transplant; transplant patient; viraemia; viral infection; viral sepsis; virus antigen; virus cytopathogenic effect; virus infection; virusemia",Pathogenesis of Murine Polyomavirus Allograft Nephropathy,,78426,ZRG1,Special Emphasis Panel,,3,383625,
7760839,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078787-04,,NIAID:367538;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATHENS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"HARN, DONALD A;",1875441;,5R01AI078787,02/15/2008,01/31/2013,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adenoviral Vector; Adenovirus Vector; Africa, Southern; Animal Welfare; Antibodies; Antigens, Viral; Automobile Driving; Bibliography; Bilharzia; CD8; CD8B; CD8B1; CD8B1 gene; Clinical Trials; Clinical Trials, Unspecified; Country; Developing Countries; Developing Nations; Development; Drivings, Automobile; Ecological impact; Environment; Environmental Impact; Epidemic; Equipment; Ethics Committees, Research; Goals; HIV vaccine; HIV-1; HIV-1 vaccine; HIV-I; HIV/AIDS Vaccines; HIV1; HIV1 vaccine; Helminths; Human immunodeficiency virus 1; IACUC; IRBs; Immune; Immune response; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; LYT3; Less-Developed Countries; Less-Developed Nations; Mammals, Mice; Mice; Murine; Mus; Names; Natural immunosuppression; Parasites; Play; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Regimen; Regulatory T-Lymphocyte; Research; Research Ethics Committees; Research Resources; Resources; Role; Schistosoma; Schistosome; Southern Africa; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; Third-World Countries; Third-World Nations; Thymus-Dependent Lymphocytes; Transmission; Under-Developed Countries; Under-Developed Nations; Vaccination; Vaccines; Vertebrate Animals; Vertebrates; Viral Antigens; Worms, Parasitic; abstracting; adeno vector; adenovector; clinical investigation; cytotoxic; driving; expiration; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; human subject; immunoresponse; immunosuppression; macrophage; mucosal site; mucosal vaccine; pathogen; plasmid vaccine; programs; response; restoration; social role; success; thymus derived lymphocyte; transmission process; vaccine candidate; vector vaccine; vertebrata; virus antigen",Effect of Helminth Infection on HIV-1 Vaccines,,78787,VACC,HIV/AIDS Vaccines Study Section,,4,367538,
7760050,R01,AI,5,,02/01/2010,01/31/2011,PA-07-320,5R01AI078848-02,,NIAID:374373;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DAVIS,UNITED STATES,PHARMACOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"GELLI, ANGELA ;",6803922;,5R01AI078848,02/01/2009,01/31/2012,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Adjuvant; Anabolism; Antifungal Agents; Antifungal Drug; Arts; Assay; Attenuated; Bioassay; Biologic Assays; Biological; Biological Assay; Body Tissues; C Cell; C. albicans; C.albicans; Calcium Channel; Calcium Channel Antagonist Receptor; Candida albicans; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cerebromeningitis; Complex; Coupled; Cryptococcal Meningitis; Cryptococcosis; Cryptococcus neoformans; Cryptococcus neoformans infection; Development; Doctor of Philosophy; Drug Combinations; Drug Compounding; Drug Evaluation, Preclinical; Drug Preparation; Drug Screening; Drugs; Economics; Encephalomeningitis; Endoplasmic Reticulum; Environment; Equilibrium; Ergastoplasm; Ergosta-5,7,22-trien-3-ol, (3beta,22E)-; Ergosterol; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Event; FRET; Fluorescence Resonance Energy Transfer; Fungal Meningitis; Fungicides, Therapeutic; Fungus Diseases; Generalized Growth; Growth; High Throughput Assay; Image; Immune Function, Cellular; Immune response; Immunologic Deficiency Syndrome, Acquired; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Industrial fungicide; Infection by Cryptococcus neoformans; Intracellular Communication and Signaling; Ion Channels, Calcium; Lead; Life; Maintenance Therapy; Mammalian Cell; Mammals, Mice; Mediating; Medication; Meningitis, Cryptococcal; Meningitis, Fungal; Meningoencephalitis; Mice; Modeling; Molecular; Mortality; Mortality Vital Statistics; Murine; Mus; Mycoses; NIH Program Announcements; Natural immunosuppression; Opportunistic Infections; Organism-Level Process; Organismal Process; Parafollicular Cell; Patch-Clamp Technics; Patch-Clamp Techniques; Patients; Pb element; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic Processes; Physiological Processes; Physiology; Play; Preclinical Drug Evaluation; Program Announcement; Receptors, Calcium Channel Blocker; Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Structure of thyroid parafollicular cell; T-Cells; T-Lymphocyte; Testing; Thymus-Dependent Lymphocytes; Tissue Growth; Tissues; Torulosis; Triazoles; VDCC; Virulence; Voltage-Dependent Calcium Channels; anti-fungal; antifungals; assay development; balance; balance function; base; biological signal transduction; biosynthesis; channel blockers; cultured cell line; drug development; drug/agent; endoplasmic reticulum stress; fungal infection; fungicidal; fungicide; fungus infection; heavy metal Pb; heavy metal lead; high throughput screening; host response; imaging; immune function; immunoresponse; immunosuppression; in vivo; inhibitor; inhibitor/antagonist; mutant; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; patch clamp; pathogen; prevent; preventing; public health relevance; screening; screenings; small molecule; small molecule libraries; social role; synergism; therapeutic target; thymus derived lymphocyte; tool",Fungal calcium channels as therapeutic targets for AIDS-associated opportunistic," 1 Angie Gelli, Ph.D.  1R01AI078848 Narrative  This study aims to understand the role of a calcium channel that governs essential physiological processes in fungal pathogens as a means to assess its viability as a target for antifungal drug development. Because fungal infections are life threatening for patients with a suppressed immune response, the development of more efficacious and better-tolerated drugs is essential.",78848,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,2,374373,
7761267,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078910-02,,NIAID:304920;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"MILLER, LLOYD S;",7571718;,5R01AI078910,02/01/2009,01/31/2014,"Abscess; Adhesion Molecule; Antibiotic Resistance; Antibiotic Therapy; Antibiotic Treatment; Antibodies, Blocking; Area; Assay; Basophilic Histiocyte; Basophils, Tissue; Bioassay; Biologic Assays; Biological Assay; Blocking Antibodies; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; CTLA-8; CTLA8; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; Cells; Chemotaxis; Cutaneous; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Defect; Dendritic Cells; Development; Drug Resistance, Multiple; Drug Resistant, Multiple; Edodekin Alfa; Family member; Future; Generations; Granulopoiesis; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Host Defense; Host Defense Mechanism; Human; Human, General; IL-1; IL-12; IL-17; IL-17A; IL-23; IL1; IL12; IL17; IL17 Protein; IL17A; Imaging Procedures; Imaging Techniques; Imaging technology; Immune; Immune response; Immune system; In Vitro; Incidence; Infection; Infectious Skin Diseases; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin I; Interleukin-1; Interleukin-12; Interleukin-17; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Langerhans cell; Lymphocyte-Stimulating Hormone; MRSA; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Marrow Neutrophil; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Mice; Modality; Modeling; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pathway interactions; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Predisposition; Prevention; Production; Public Health; Publishing; Receptor Activation; Research; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistance to antibiotics; Resistance, Antibiotic; Resistant to Multiple Drug; Resistant to antibiotics; Resistant to multi-drug; Resistant to multidrug; Role; S. aureus; S.aureus; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin; Skin Diseases, Infectious; Staphylococcus aureus; Susceptibility; Syringes; System; System, LOINC Axis 4; T Helper Factor; T-Cells; T-Lymphocyte; TIL4; TLR protein; TLR2; TLR2 gene; Technics, Imaging; Testing; Therapeutic; Thick; Thickness; Thymus-Dependent Lymphocytes; Time; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Translating; Translatings; Veiled Cells; Virulent; antibiotic resistant; base; biological signal transduction; body system, allergic/immunologic; cell adhesion protein; chemoattractant cytokine; chemokine; combat; cytokine; effective therapy; experiment; experimental research; experimental study; host response; human disease; immunoresponse; in vivo; in vivo Model; innovate; innovation; innovative; insight; interleukin-23; interventional strategy; keratinocyte; language translation; lymphocyte activating factor; macrophage; mast cell; mastocyte; methicillin resistant Staphylococcus aureus (organism); mouse model; multi-drug resistant; multidrug resistant; neutrophil; new therapeutics; next generation therapeutics; novel; novel therapeutics; organ system, allergic/immunologic; pathogen; pathway; public health medicine (field); public health relevance; research study; resistant strain; response; skin infection; social role; therapeutic target; thymus derived lymphocyte; treatment of bacterial diseases; treatment of bacterial infectious disease; yellow-1",Innate Immune Response to Staphylococcus aureus in Skin," Relevance to Public Health Staphylococcus aureus skin infections represent a major public health threat in the U.S. as a result of the dramatic increased incidence of these infections and the widespread emergence of virulent and antibiotic- resistant strains. The ultimate objective of this proposal is to uncover novel insights into mechanisms of host defense against S. aureus skin infection and to use these insights to develop innovative immune-based therapeutic strategies that will provide the groundwork for future prevention and treatment interventions against S. aureus skin infections. We believe that this area of research is highly significant, since the need for new and effective treatment modalities are desperately needed to help combat these infections, which are becoming increasingly resistant to antibiotic therapy.",78910,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,2,304920,
7762759,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078947-02,,NIAID:397734;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,STANFORD,UNITED STATES,PATHOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"BOGYO, MATTHEW S;",8043807;,5R01AI078947,02/01/2009,01/31/2014,"Affect; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Antiproteases; Assay; Bioassay; Biochemical; Biochemical Process; Biologic Assays; Biological; Biological Assay; Biology; Blood; Blood erythrocyte; Blood normocyte; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Cessation of life; Combinatorial Synthesis; Computer Simulation; Computerized Models; Country; Coupled; Cysteine Endopeptidases; Cysteine Protease; Cysteine Protease Inhibitors; Cysteine Proteinase Antagonists; Cysteine Proteinase Inhibitors; Cysteine Proteinases; Death; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Endopeptidase Inhibitors; Erythrocytes; Erythrocytic; Esteroproteases; Event; Foundations; Future; Generations; Genetic; Human; Human, General; Individual; Infection; Invaded; Knowledge; L-Serine; Label; Lead; Libraries; Link; Lytic; Malaria; Man (Taxonomy); Man, Modern; Maps; Marrow erythrocyte; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Methods; Modeling; Models, Computer; Monitor; Mortality; Mortality Vital Statistics; Paludism; Parasites; Pathology; Pathway interactions; Pb element; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Plasmodium Infections; Plasmodium berghei; Plasmodium falciparum; Process; Protease Antagonists; Protease Inhibitor; Proteases; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; Proteomics; Reagent; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Research; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Role; Rupture; Screening procedure; Serine; Simulation, Computer based; Solid; Specific qualifier value; Specificity; Specified; Staging; Stream; Structure-Activity Relationship; Therapeutic; Therapeutic Intervention; Thiol Protease; Validation; Work; analog; base; blood corpuscles; cell sorting; chemical structure function; chemical synthesis; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease/disorder; heavy metal Pb; heavy metal lead; improved; in silico; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; mouse model; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathogen; pathway; public health relevance; rodent plasmodia; scaffold; scaffolding; screening; screenings; small molecule; social role; structure function relationship; tool; treatment strategy; virtual simulation",Chemically Mapping Malarial Rupture Proteases," PROJECT NARRATIVE This project outlines plans to use small molecules to identify proteases used by the parasite pathogen, Plasmodium falciparum, to mediate rupture of host red blood cells during the blood stage infection of a human host. This work will lead to the identification of potentially valuable targets for development of new therapeutic treatment strategies for malaria.",78947,SBCB,Synthetic and Biological Chemistry B Study Section,,2,397734,
7766992,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI078993-02,,NIAID:324864;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,OKLAHOMA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"LANG, MARK L;",7929251;,5R01AI078993,02/15/2009,01/31/2014,"ATGN; Adoptive Transfer; Affect; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigens; B Cell Differentiation Factor I; B blood cells; B cell growth factor 2; B-Cell Growth Factor-II; B-Cells; B-Lymphocytes; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); Binding; Binding (Molecular Function); Blood Plasma Cell; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD154; CD154 Antigens; CD40 Ligand; CD40-L; CD40L; CD40LG; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; DIF; Data; Development; EDF; Eo-CSF; Eosinophil Differentiation Factor; Family member; Future; Galactocerebrosides; Galactosyl Ceramides; Galactosylceramides; Generations; Glycolipids; HIGM1; Humoral Immunities; IL-5; IL5; IMD3; IgA enhancing factor; Immune response; Immune system; Immunities, Humoral; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin-5; Label; Learning; Length of Life; Life; Longevity; Maintenance; Maintenances; Mammals, Mice; Mediating; Memory B Cell; Memory B-Lymphocyte; Mice; Molecular Interaction; Murine; Mus; Myeloid Cells; Plasma Cells; Plasmacytes; Procedures; Proteins; Regulation; Reporting; Research; Reticuloendothelial System, Bone Marrow; Sensitization, Immunologic; Sensitization, Immunological; Subcellular Process; Supporting Cell; T cell replacing factor; T-B Cell Activating Molecule; T-Cell Replacing Factor; TNF; TNF A; TNF gene; TNF-Related Activation Protein; TNFSF2; TNFSF5; TNFSF5 gene; TRAP Gene; Testing; Time; Tumor Necrosis Factor Gene; Tumor Necrosis Factor Ligand Superfamily Member 5; Vaccines; Work; antibody biosynthesis; antibody-based immunity; body system, allergic/immunologic; cytokine; design; designing; experiment; experimental research; experimental study; gene product; gp39; gp39 Antigen, T-Cell; host response; immunogen; immunoglobulin biosynthesis; immunoresponse; improved; in vitro Assay; in vivo; life span; lifespan; neutralizing antibody; new vaccines; next generation vaccines; novel; novel vaccines; organ system, allergic/immunologic; pathogen; plasma cell development; plasmocyte; public health relevance; reconstitute; reconstitution; research study; response; vaccination strategy",Regulation of humoral immunity by NKT cells," Proposal Narrative Most successful vaccines stimulate long-lived humoral immune responses mediated by protective antibody. Despite remarkable progress in understanding the mechanisms by which humoral immunity is induced and sustained, there is much to learn. This is of particular importance if we are to develop novel vaccines in the future against remaining pathogens for which there is no vaccine. We have discovered that activation of NKT cells enhances primary and recall antibody responses. Our data indicate that this is due to increasing the generation of memory B cells, the precursor of antibody-secreting plasma cells and by increasing the persistence of plasma cells. Our project will assess the impact of NKT cells on memory B cell and plasma cell induction and maintenance. We will then conduct mechanistic studies to understand how NKT cells achieve their effects on memory B cells and plasma cells. Our work will advance the understanding of the mechanisms by which NKT cells affect humoral immune responses and may highlight new opportunities to develop novel vaccine strategies.",78993,IHD,Immunity and Host Defense Study Section,,2,324864,
7915353,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI079253-02,,NIAID:425678;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BUFFALO,UNITED STATES,,28,824771034,US,NY,14263,ROSWELL PARK CANCER INSTITUTE CORP,"SEGAL, BRAHM H;",7322840;,5R01AI079253,02/01/2009,01/31/2014,"Acute; Adoptive Transfer; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apopain; Apoptosis; Apoptosis Pathway; Attenuated; Biological; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Bone Marrow; CASP-3; CASP3; CGD; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; CR3; CR3 Receptor; CSF3; CSF3 gene; CTLA-8; CTLA8; Cancers; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase 3, Apoptosis-Related Cysteine Protease; Caspase-1; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Death, Programmed; Cell Nucleus; Cell Signaling; Cell Wall; Cells; Chronic Granulomatous Disease; Closure by Ligation; Complex; Cysteine; Cysteine Protease CPP32; Cytokines, Chemotactic; Cytoplasmic Granules; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Defect; Disease; Disorder; Dissociation; EC 3.4.22.36; Enzymes; Erythroid; Esteroproteases; Feedback; Fungus Diseases; G-CSF; GCSF; Genetic Diseases, Inborn; Genetically Engineered Mouse; Granulomatous Disease, Chronic; Half-Cystine; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Host Defense; ICE Protease; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-17; IL-17A; IL-1b Converting Enzyme; IL17; IL17 Protein; IL17A; IL1B-Convertase; IL1BC; INFLM; Imidazole; In Vitro; Inborn Genetic Diseases; Infection; Inflammation; Inflammatory; Inflammatory Response; Inherited disorder; Injury; Integrin alpha-M beta-2; Integrin alphaMbeta2; Intercrines; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-17; Interleukin-1beta Converting Enzyme; Intracellular Communication and Signaling; L-Cysteine; LPS; Lead; Life; Ligands; Ligation; Lipopolysaccharides; Lung; Lung Inflammation; MGC45931; Mac 1; Mac-1 Adhesive Receptor; Mac-1 Antigen; Mac-1 Receptor; Macrophage-1 Antigen; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Neutrophil; Mice; Modeling; Murine; Mus; Mycoses; NADPH Oxidase; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nuclear; Nucleus; Oxidants; Oxidation-Reduction; Oxidizing Agents; P45; PARP Cleavage Protease; Pathologic; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Phagocytes; Phagocytic Cell; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteolytic Enzymes; Receptor Protein; Receptor, Complement 3; Receptor, Mo1 Antigen; Receptor, Mo1 Glycoprotein; Recurrence; Recurrent; Redox; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Role; SCA-1; SIS cytokines; SREBP Cleavage Activity 1; Signal Transduction; Signal Transduction Systems; Signaling; Superoxide Anion; Superoxide Radical; Superoxides; TIL4; TLR protein; TLR2; TLR2 receptor; TLR4 receptor; Testing; Therapeutic; Toll-4 receptor; Toll-Like Receptor 2; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; Toxin; UV irradiated; UV irradiation; UV irridated; Yama; Yama protein; Zymosan; amebocyte; attenuation; base; biological signal transduction; caspase-3; chemoattractant cytokine; chemokine; cysteine protease P32; cytokine; dectin 1; disease/disorder; electron acceptor; environmental agent; fungal infection; fungus infection; granule; heavy metal Pb; heavy metal lead; in vivo; inborn error; inhibitor; inhibitor/antagonist; macrophage; malignancy; microbial; mouse model; neoplasm/cancer; neoplastic; neutrophil; novel; oxidation; oxidation reduction reaction; pathogen; pathway; public health relevance; pulmonary; receptor; response; social role; therapeutic target; toll-like receptor 4; tumor; ultra violet irradiation; ultraviolet irradiation",Role of NADPH Oxidase in Regulating Inflammation," Project Narrative Chronic granulomatous disease (CGD) is a rare inherited disorder of the he NADPH oxidase, a critical component of host defense against microbial pathogens. Our proposal will evaluate mechanisms by which NADPH oxidase regulates inflammation that will be important to our understanding of CGD, and will be broadly relevant to pathologic conditions, such as inflammatory disorders and cancer.",79253,III,Innate Immunity and Inflammation Study Section,,2,425678,
7764787,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI079665-02,,NIAID:470003;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"DE LA TORRE, JUAN C.;",1866632;,5R01AI079665,02/15/2009,01/31/2013,"1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; Acute; Acute-Phase Reaction; Acute-Phase State; Adverse effects; Affect; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Arenavirus; Arenavirus Infections; Argentine hemorrhagic fever virus; Assay; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Biological Terrorism; Bioterrorism; Categories; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Regulation; Cessation of life; Complex; Cultured Cells; Data; Death; Development; Disease; Disorder; Drug resistance; Drugs; ELIG; Eligibility; Eligibility Determination; Escape Mutant; Esteroproteases; Exhibits; Experimental Models; Experimental Models, Other; Frequencies (time pattern); Frequency; Genetic Determinism; Genetics-Mutagenesis; Glycoproteins; Goals; Golgi; Golgi Apparatus; Golgi Complex; Health; Hemorrhagic Fever Virus, Argentinian; Hemorrhagic Fevers, Viral; Human; Human, General; Individual; Infection; Integral Membrane Protein; Intrinsic Membrane Protein; Junin; Junin virus; Knowledge; LCM Viruses; LCMV; Lassa fever virus; Lassa virus; Libraries; Licensing; Lymphocytic choriomeningitis virus; Man (Taxonomy); Man, Modern; Mediating; Medication; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Model System; Models, Biologic; Models, Experimental; Molecular; Molecular Biology, Mutagenesis; Molecular Mechanisms of Action; Monitor; Mutagenesis; Normal Cell; Pathogenesis; Peptidases; Peptide Hydrolases; Peptides; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Preparedness; Process; Production; Property; Property, LOINC Axis 2; Proteases; Protein Binding; Proteinases; Proteins; Proteolytic Clipping; Proteolytic Enzymes; Proteolytic Processing; Protocol Screening; Public Health; RNA chemical synthesis; RNA synthesis; RNA, Viral; RTCA; Readiness; Regulation; Resistance; Response, Acute-Phase; Ribavirin; Ribovirin; Risk; Role; S1P enzyme; SKI-1 enzyme; Site; Stress; Structure; Subcellular Process; Testing; Therapeutic Index; Therapeutic Intervention; Time; Toxic effect; Toxicities; Transmembrane Protein; Treatment Side Effects; Tribavirin; Vaccines; Variant; Variation; Viral; Viral Diseases; Viral Genetics; Viral Hemorrhagic Fevers; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Viruses, General; base; biodefense; biological adaptation to stress; cell growth regulation; cell killing; cellular targeting; clinical significance; clinically significant; combat; combinatorial; congenital infection; design; designing; disease/disorder; drug candidate; drug resistant; drug/agent; fat metabolism; fitness; gene product; genetic determinant; hemorrhagic fever; immunosuppressed; in vitro Assay; inhibitor; inhibitor/antagonist; interest; intervention therapy; lipid metabolism; neglect; novel; nucleoside analog; pathogen; public health medicine (field); public health relevance; reaction; crisis; resistance to Drug; resistant; resistant to Drug; response; side effect; site-1 protease; small molecule; small molecule libraries; social role; stress response; stress; reaction; subtilase subtilisin kexin isozyme-1; subtilisin-kexin isozyme SKI-1; therapy adverse effect; transcription factor; treatment adverse effect; treatment of viral infectious disease; viral RNA; viral infection; virus RNA; virus genetics; virus infection; virus multiplication",Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.," Several arenaviruses, chiefly Lassa fever virus, cause severe hemorrhagic fever (HF) disease in humans, and evidence indicates that the worldwide-distributed prototypic Arenavirus LCMV is a neglected human pathogen of clinical significance. In addition, weaponized forms of arenaviruses pose a serious threat as agents of bioterrorism. No licensed anti-arenavirus vaccines are available, and current anti-arenavirus therapies are limited to the use of ribavirin, which is only partially effective and often associated with severe side effects. Therefore, the development of better antiviral strategies to combat pathogenic arenaviruses is highly relevant to human health, a task that is further complicated by the existing limited knowledge about the mechanisms underlying arenavirus pathogenesis. Our proposal is designed to examine the contribution of the GP-S1P interaction to arenavirus pathogenesis, and to provide a comprehensive assessment of the feasibility of inhibiting the S1P-mediated processing of the virus GPC as a novel antiviral strategy to combat arenavirus infections.",79665,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,470003,
7769479,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI080328-02,,NIAID:324720;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"BLANKSON, JOEL N;",1925640;,5R01AI080328,02/15/2009,01/31/2013,"AIDS; AIDS Antigens; AIDS Virus; APC; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Alleles; Allelomorphs; Antigen Processing; Antigen Processings; Antigen-Presenting Cells; Assay; Autologous; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Bypass; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ Cell Counts; CD4+ Counts; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cell Function; Cell Mediated Immunology; Cell Process; Cell physiology; Cell-Mediated Immunity; Cells; Cells, CD4; Cellular Function; Cellular Immunity; Cellular Physiology; Cellular Process; Class I Antigens; Class I Major Histocompatibility Antigens; Complex Class 1; Consensus; Cytofluorometry, Flow; Cytotoxic cell; Defective Hybrids; Defective Interfering Particles; Defective Interfering Viruses; Defective Viruses; Detection; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drops; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frequencies (time pattern); Frequency; Gagging; Genes, Class I; Genes, MHC Class I; Genetic Alteration; Genetic Change; Genetic defect; Grant; HIV; HIV Antigens; HIV-1; HIV-1 vaccine; HIV-Associated Antigens; HIV-I; HIV1; HIV1 vaccine; HTLV-III; HTLV-III Antigens; HTLV-III-LAV Antigens; Histocompatibility Antigens Class I; Host Factor; Host Factor Protein; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Humoral Immunities; Immune response; Immune system; Immunities, Humoral; Immunity, Cellular; Immunodeficiency Virus Type 1, Human; Immunologic Accessory Cells; Immunologic Deficiency Syndrome, Acquired; Immunologic, Immunochemical; Immunologics; Incomplete Viruses; Individual; Infection; Integration Host Factors; K lymphocyte; Killings; Kinetic; Kinetics; LAV Antigens; LAV-HTLV-III; LYT3; Laboratories; Lymphadenopathy-Associated Antigens; Lymphadenopathy-Associated Virus; MHC Class I; MHC Class I Genes; MHC Class I Molecule; MHC Class I Protein; MHC class I antigen; MTGN; Major Histocompatibility Complex Class 1; Mediating; Memory; Microfluorometry, Flow; Mitogens; Modeling; Monocytes / Macrophages / APC; Mutation; NK Cells; Natural Killer Cells; Patients; Peptides; Physiologic; Physiological; Plasma; Play; Predisposition; Progressive Disease; Proliferating; Proteins; Proviruses; Reflex, Pharyngeal; Reporting; Resistance; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Specificity; Subcellular Process; Susceptibility; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Antigens, Human; T4 Cells; T4 Lymphocyte Count; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Time; Viral; Viral Burden; Viral Load; Viral Load result; Viremia; Virus; Virus-HIV; Viruses, General; Work; accessory cell; antibody-based immunity; antigen processing; antiretroviral therapy; body system, allergic/immunologic; cytokine; cytotoxic; design; designing; disease/disorder; fitness; flow cytophotometry; gene product; genome mutation; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; immunoresponse; improved; in vivo; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; public health relevance; recombinant virus; resistant; response; social role; therapeutic vaccine; thymus derived lymphocyte; vaccine development; viraemia; viral sepsis; virusemia",CD8+ T cell mediated inhibition of HIV-1 replication in Elite Suppressors," Most patients infected with HIV-1 will develop a drop in their CD4 counts and frank AIDS as the virus replicates and destroys the immune system. A unique group of untreated HIV-1-infected patients, termed Elite Supressors (ES) are able to completely control the virus and do not develop AIDS (1-3). This project plans to determine how CD8+ T cells from ES control the virus; the results may be applicable to the development of an effective HIV-1 vaccine.",80328,AIP,AIDS Immunology and Pathogenesis Study Section,,2,324720,
7744630,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI080337-02,,NIAID:676454;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BISSON, GREGORY P.;",7538746;,5R01AI080337,02/01/2009,01/31/2014,"21+ years old; AFB; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Accounting; Acid Fast; Acid Fast Bacillae; Acid Fast Bacillae Staining Method; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adherence; Adherence (attribute); Adopted; Adult; Africa, Southern; After Care; After-Treatment; Aftercare; Antiretroviral Therapy, Highly Active; Availability of Health Services; Bacillus; Bacillus (bacterium); Bechuanaland; Botswana; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ Cell Counts; CD4+ Counts; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cause of Death; Cell Count; Cell Mediated Immunology; Cell Number; Cell-Mediated Immunity; Cells; Cells, CD4; Cellular Immunity; Cessation of life; Clinical; Cohort Studies; Concurrent Studies; Data; Death; Diagnosis; Disease; Disorder; Future; Gamma interferon; Gene Products, RNA; Genus Mycobacterium; Goals; Grant; HAART; HIV; HIV Infections; HIV-1; HIV-I; HIV/AIDS; HIV/AIDS problem; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Services Accessibility; Heterogeneity; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, Adult; IFN-Gamma; IFN-g; IFNG; Immune; Immune Function, Cellular; Immune response; Immunity, Cellular; Immunodeficiency Virus Type 1, Human; Immunologic, Immunochemical; Immunologics; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Inflammatory; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Intervention; Intervention Strategies; Knowledge; LAV-HTLV-III; Life; Literature; Lung TB; Lung Tuberculosis; Lymphadenopathy-Associated Virus; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Measurement; Measures; Medical; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mycobacterium; Mycobacterium tuberculosis; Opportunistic Infections; Organism; Outcome; PBMC; Pathway interactions; Patient Care; Patient Care Delivery; Patients; Peripheral Blood Mononuclear Cell; Programs (PT); Programs [Publication Type]; Prospective Studies; Public Health; Pulmonary TB; Pulmonary Tuberculosis; RNA; RNA, Non-Polyadenylated; Recovery; Regimen; Research; Research Proposals; Research Resources; Resources; Ribonucleic Acid; Risk; Risk Factors; Southern Africa; Sputum; Staging; Syndrome; T-Lymphotropic Virus Type III Infections, Human; T4 Cells; T4 Lymphocyte Count; T4 Lymphocytes; Testing; Time; Tuberculosis; Tuberculosis, Pulmonary; Update; Viral Burden; Viral Load; Viral Load result; Virus-HIV; access to services; access to treatment; adult human (21+); advanced disease; anti-retroviral therapy, highly active; antiretroviral therapy; availability of services; base; clinical care; clinical relevance; clinically relevant; combat; design; designing; disease/disorder; disseminated TB; disseminated tuberculosis; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; helper T cell; high risk; host response; human T cell leukemia virus III; human T lymphotropic virus III; immune function; immunoresponse; improved; interventional strategy; lFN-Gamma; living system; pathogen; pathway; prevent; preventing; primary outcome; programs; prospective; public health medicine (field); public health relevance; reconstitute; reconstitution; response; restoration; scale up; tuberculous spondyloarthropathy",Immunology and Outcomes after HAART in HIV/TB Coinfection," Project Narrative This research proposal evaluates the relationship between very early response to HAART and risk of death in the first 6 months after HAART initiation among adults with advanced HIV disease and active tuberculosis (TB) disease, the most important opportunistic infection globally. Conducted as a prospective cohort study in Gaborone, Botswana, the project will yield important information to clinical care and public health efforts designed to improve the outcomes in global antiretroviral therapy scale-up efforts.",80337,ACE,AIDS Clinical Studies and Epidemiology Study Section,,2,676454,
7766196,R01,AI,5,,02/01/2010,01/31/2011,PA-07-320,5R01AI080651-02,,NIAID:270139;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ITHACA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"RUSSELL, DAVID G;",1880452;,5R01AI080651,02/15/2009,01/31/2012,"Active Follow-up; Address; Africa South of the Sahara; Anti Mycobacterial Agents; Anti-Bacterial Agents; Antibacterial Agents; Antimycobacterial Agents; Appearance; Area; Assay; Bacteria; Bioassay; Biologic Assays; Biological Assay; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chemicals; Clinical; Colony-forming units; Communicable Diseases; Communities; Complex; Death; Development; Disease; Disorder; Dogs; Drug Combinations; Drug Compounding; Drug Evaluation, Preclinical; Drug Preparation; Drug Screening; Drug Therapy; Drug resistance; Drugs; Effectiveness; Environment; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Exclusion; Exposure to; Genomics; Goals; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; High Throughput Assay; Human; Human, General; Hypersensitivity skin testing; Immune; Immunocompetence; Immunologic Competence; Immunologic, Luciferase; Immunological Competence; Incidence; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intracellular Communication and Signaling; Killings; Lead; Location; Luciferases; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Malnutrition; Mammals, Dogs; Man (Taxonomy); Man, Modern; Marketing; Measurement; Measures; Mediating; Medication; Method LOINC Axis 6; Methodology; Modification; Mycobacterium tuberculosis; NIAID; NIH; NIH Program Announcements; Names; National Institute of Allergy and Infectious Disease; National Institutes of Health; National Institutes of Health (U.S.); Nutrient; Nutritional Deficiency; Organism; Oxidation-Reduction; Pb element; Penetrance; Performance; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacotherapy; Planets; Population; Position; Positioning Attribute; Poverty; Preclinical Drug Evaluation; Pressure; Pressure- physical agent; Process; Program Announcement; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Publishing; Redox; Reporter; Research; Resolution; Running; Scheme; Science of Statistics; Scientific Advances and Accomplishments; Screening procedure; Series; Signal Transduction; Signal Transduction Systems; Signaling; Skin Tests; Specificity; Statistics; Stress; Sub-Saharan Africa; Subcellular Process; Subsaharan Africa; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Tuberculosis; Undernutrition; United States National Institutes of Health; Universities; anti-bacterial; anti-microbial; antibacterial; antimicrobial; antimycobacterial; assay development; bactericidal; bactericide; base; biological signal transduction; canine; clinical applicability; clinical application; cytotoxic; design; designing; dietary deficiency; disease/disorder; disseminated TB; disseminated tuberculosis; domestic dog; drug development; drug resistant; drug/agent; experience; fitness; follow-up; heavy metal Pb; heavy metal lead; high throughput screening; hypersensitivity test; immunologic skin test; in vivo; living system; macrophage; member; mycobacterial; oxidation reduction reaction; pathogen; pressure; programs; public health relevance; resistance to Drug; resistant strain; resistant to Drug; response; scientific accomplishments; scientific advances; screening; screenings; small molecule; statistics; tuberculosis treatment; tuberculous spondyloarthropathy",Development of a cell-based HTS for compounds with activity against tuberculosis," Project Narrative / Relevance This proposal is in answer to the Program Announcement PA-07-320, which calls for ""Development of assays for high-throughput drug screening"". It details approaches for identification of compounds that are bactericidal to Mycobacterium tuberculosis inside macrophages, which mimics its environment in vivo. Tuberculosis continues to be a global threat to mankind, and is named specifically by the NIAID in this announcement. Recent advances have placed us in a strong position to use our scientific advances to design and execute a new HTS platform to identify small molecules capable of killing intracellular M. tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease.",80651,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,270139,
7769569,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI080715-02,,NIAID:470003;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"KAUFMANN, GUNNAR JOERG FLORIS;",9354200;,5R01AI080715,02/12/2009,01/31/2014,"AIDS/HIV; AIDS/HIV problem; Affinity; American; Animal Model; Animal Models and Related Studies; Anti-Infective Agents; Anti-Infective Drugs; Anti-Infectives; Anti-infective Preparation; AntiInfective Drugs; AntiInfectives; Antibiotic Resistance; Antibiotic Resistance, Bacterial; Antibodies; Antiinfective Agents; Area; Bacteria; Bacterial Antibiotic Resistance; Bacterial Infections; Behavior Control; Behavioral Manipulation; Bioluminescence; CDC; Carrier Proteins; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Chemicals; Chemistry; Chimp; Chimpanzee; Coin; Communication; Complex; DNA Molecular Biology; Data; Development; Engineering; Engineerings; Gene Expression; Generations; Gram-Negative Bacteria; Gram-Positive Bacteria; HIV/AIDS; HIV/AIDS problem; Haptens; Human; Human, General; ITX; IgA; Immune Globulins; Immune response; Immune system; Immunization, Passive; Immunoglobulin A; Immunoglobulins; Immunoglobulins / Antibodies; Immunologically Directed Therapy; Immunotherapeutic agent; Immunotherapy; In Vitro; Infection; Intracellular Communication and Signaling; Investigation; Length; Lytotoxicity; MRSA; Mammalian Cell; Man (Taxonomy); Man, Modern; Methicillin Resistant S. Aureus; Methicillin Resistant Staphylococcus Aureus; Microbial Biofilms; Molecular Biology; Oligopeptides; P. aeruginosa; P.aeruginosa; Pan; Pan Genus; Pan Species; Passive Immunization; Pathogenesis; Pathogenicity Factors; Phage Display; Population; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Reagent; Research; Research Proposals; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; S. aureus; S.aureus; Science of Chemistry; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Solid; Staphylococcus aureus; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Therapeutic Agents; Transport Proteins; Transporter Protein; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Vaccination; Vaccines; Variant; Variation; Vibrio fischeri; Virulence; Virulence Factors; anti-microbial agent; anti-microbial drug; antibiotic resistant; antibiotic resistant, bacterial; antimicrobial agent; antimicrobial drug; bacterial disease; base; behavioral control; biofilm; biological signal transduction; body system, allergic/immunologic; clinical relevance; clinically relevant; combat; communicable disease control agent; cytotoxicity; design; designing; experiment; experimental research; experimental study; fighting; homoserine lactone; host response; immune therapy; immunologic preparation; immunoresponse; immunotherapeutics; improved; in vitro Assay; in vivo; member; methicillin resistant Staphylococcus aureus (organism); microbial; model organism; mouse model; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathogen; prevent; preventing; programs; prophylactic; protein metabolite; public health relevance; quorum sensing; research study; resistance to antibiotic, bacterial; small molecule; therapeutic target",Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy," Bacterial pathogens, even so-called antibiotic-resistant ""super bugs"", utilize cell-to-cell signaling, a process termed ""quorum sensing"", to control their virulence. The molecules that bacteria use for their communication represent attractive targets for anti-infective therapy as the scavenging of the small compounds would render the bacteria harmless. We propose to develop antibodies and harness the immune system in general for the disruption of bacterial quorum sensing and thus, a new strategy in fighting bacterial infections.",80715,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,470003,
7771739,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI081510-02,,NIAID:451688;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,786658872,US,NY,100169102,AARON DIAMOND AIDS RESEARCH CENTER,"TSUJI, MORIYA ;",1894578;,5R01AI081510,02/19/2009,01/31/2013,"0-11 years old; ATGN; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Affect; Africa; Anti-Malarials; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigenic Determinants; Antigens; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Arm; B-Cell Epitopes; B-Lymphocyte Epitopes; Binding Determinants; Blood erythrocyte; Blood normocyte; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Capsid; Capsid Proteins; Cell Function; Cell Process; Cell physiology; Cell/Tissue, Immunohistochemistry; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular Tropism; Child; Child Youth; Children (0-21); Coat Proteins; Communicable Diseases; Disease; Disorder; Dose; Epitopes; Epitopes, B-Lymphocyte; Erythrocytes; Erythrocytic; Fiber; Figs; Figs - dietary; Human, Child; Humoral Immunities; IHC; Immune response; Immunities, Humoral; Immunity; Immunization; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; LYT3; Lead; Malaria; Malaria Vaccines; Malarial Vaccines; Mammals, Mice; Marrow erythrocyte; Mediating; Mice; Modification; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Nature; Paludism; Parasites; Pb element; Phagocytes; Phagocytic Cell; Plasmodium Infections; Plasmodium yoelii; Process; Production; Proteins; Recombinants; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regimen; Reticuloendothelial System, Erythrocytes; Sensitization, Immunologic; Sensitization, Immunological; Staging; Subcellular Process; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Tissues; Transgenes; Upper arm; Vaccinated; Vaccination; Vaccines; Viral Coat Proteins; Viral Outer Coat Protein; Virus; Viruses, General; adeno vector; adenovector; amebocyte; antibody biosynthesis; antibody-based immunity; base; blood corpuscles; children; circumsporozoite; circumsporozoite protein; coat (nonenveloped virus); cs protein; disease/disorder; fluorophore; gene product; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunogenicity; immunoglobulin biosynthesis; immunoresponse; in vivo; novel; prevent; preventing; public health relevance; response; thymus derived lymphocyte; trafficking; youngster",Optimizing adenoviral vector to elicit a potent anti-malaria immunity," PROJECT NARRATIVE Malaria is still a devastating disease. The aim of this project is to develop a new adenovirus- based malaria vaccine that can elicit not only a strong malaria-specific cellular response, but also a robust malaria-specific humoral response. The simultaneous induction of high levels of both arms of the immune responses should lead to a successful induction of a potent protective immunity against malaria, thus ultimately placing Ad-based malaria vaccine, as a promising vaccine.",81510,VMD,Vaccines Against Microbial Diseases Study Section,,2,451688,
7779479,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI081534-02,,NIAID:432828;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"DEMIRCI, UTKAN ;",8635578;,5R01AI081534,03/03/2009,02/28/2014,"0-11 years old; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Age; Anti-Retroviral Agents; Antiretroviral Agents; Appointment; Area; Au element; Award; Biology; Blood; Blood Sample; Blood Tests; Blood specimen; Breast; CCD camera; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ Cell Counts; CD4+ Counts; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cancers; Care, Health; Caring; Cell Count; Cell Number; Cells; Cells, CD4; Chemistry; Child; Child Youth; Children (0-21); Clinical; Clinical Research; Clinical Study; Collaborations; Communities; Country; Cytofluorometry, Flow; Detection; Developed Countries; Developed Nations; Developing Countries; Developing Nations; Development; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Economic Income; Economical Income; Engineering; Engineerings; Ensure; Fellowship; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Fluorescence Microscopy; Foundations; Gastrointestinal Tract, Pancreas; Genital System, Male, Prostate; Genomics; Gold; Guidelines; HIV; HOSP; HTLV-III; Health; Health Sciences; Healthcare; Hematologic Tests; Hematological Tests; Hematology Testing; Hospitals; Human Immunodeficiency Viruses; Human Prostate; Human Prostate Gland; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Child; Image; Income; Individual; Industrialized Countries; Industrialized Nations; Infrastructure; Institutes; Intelligence; Investigators; Jamaica; LAV-HTLV-III; Label; Laboratories; Lead; Less-Developed Countries; Less-Developed Nations; Life; Light; Link; Lymphadenopathy-Associated Virus; Lymphocyte Count; Lymphocyte Number; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Marketing; Massachusetts; Measures; Medical; Medicine; Methods; Methods and Techniques; Methods, Other; Microfluidic; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Microfluidics; Microfluorometry, Flow; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Monitor; Operations Research; Pancreas; Pancreatic; Patients; Pb element; Persons; Photoradiation; Position; Positioning Attribute; Preparation; Prevention; Price; Principal Investigator; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; R01 Mechanism; R01 Program; RPG; Relative; Relative (related person); Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Rheumatic Heart Disease; Rural; Rural Community; Sampling; Schools, Medical; Science of Chemistry; Science of Medicine; Security; Shadowing; Shadowing (Histology); Solutions; Surface; System; System, LOINC Axis 4; T4 Cells; T4 Lymphocyte Count; T4 Lymphocytes; Tanzania; Techniques; Technology; Testing; Therapeutic; Third-World Countries; Third-World Nations; Tissue Engineering; Total Lymphocyte Count; Treatment outcome; Tumor Cell; Under-Developed Countries; Under-Developed Nations; United Republic of Tanzania; Virus-HIV; WHBLOOD; Whole Blood; Woman; Work; World Health; anti-retroviral; antiretroviral; antiretroviral therapy; base; charge coupled device camera; children; cost; design; designing; device development; drug discovery; engineered tissue; flow cytophotometry; heavy metal Pb; heavy metal lead; helper T cell; imaging; improved; instrument development; malignancy; medical schools; microchip; nano; nano engineering; nano meter scale; nano meter sized; nano scale; nanoengineering; nanometer scale; nanometer sized; nanoscale; neoplasm/cancer; neoplastic cell; novel; point of care; pricing; professor; prognostic; programs; prototype; public health relevance; sensor; success; tool; treatment response; youngster",Point-of-Care Rapid Blood Testing Using Microfluidic Devices,,81534,ZRG1,Special Emphasis Panel,,2,432828,
7766256,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI081615-02,,NIAID:451688;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,786658872,US,NY,100169102,AARON DIAMOND AIDS RESEARCH CENTER,"MUESING, MARK AYER;",2071996;,5R01AI081615,02/15/2009,01/31/2014,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Affinity; Antigenic Determinants; Antigens; Antiviral Agents; Antiviral Drugs; Antivirals; Binding; Binding (Molecular Function); Binding Determinants; Biochemical; Biological; Biological Function; Biological Preservation; Biological Process; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Code; Coding System; Complex; DNA; DNA Viruses; DNA, Viral; Deoxyribonucleic Acid; Engineering; Engineerings; Envelope Protein; Environment; Enzymes; Epitopes; Funding; Gene Products, env; Gene Products, vif; Gene Targeting; Generalized Growth; Genetic; Genetic Code; Genetics-Mutagenesis; Genome; Growth; HIV; HIV Infections; HIV-1; HIV-1 Integrase; HIV-I; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Host Factor; Host Factor Protein; Human; Human Activities; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Immunodeficiency Virus Type 1, Human; Import, Nuclear; Infection; Integrase; Integrase, HIV-1; Integration Host Factors; Intervention; Intervention Strategies; Investigation; LAV-HTLV-III; Life Cycle; Life Cycle Stages; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Mutagenesis, Site-Directed; Nuclear Import; Photometry/Spectrum Analysis, Mass; Preservation, Biologic; Preservation, Biological; Procedures; Process; Proteins; Proteome; Proteomics; Protocol; Protocols documentation; Reverse Transcription; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sound; Sound - physical agent; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure-Activity Relationship; Subcellular Process; Surface; Survey Instrument; Surveys; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; Targeted DNA Modification; Targeted Modification; Targetings, Gene; Techniques; Thymus-Dependent Lymphocytes; Tissue Growth; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Vaccines; Viral; Viral Envelope Proteins; Viral Gene Products; Viral Gene Proteins; Viral Genome; Viral Proteins; Virion; Virus; Virus Particle; Virus-HIV; Viruses, General; base; chemical structure function; cryogenics; env Antigens; env Gene Products; env Polyproteins; env Protein; gene product; human T cell leukemia virus III; human T lymphotropic virus III; immunogen; immunological intervention; insight; interventional strategy; life course; novel; ontogeny; preservation; protein complex; protein protein interaction; public health relevance; recombinant virus; small molecule; sor Gene Products; sound; structure function relationship; thymus derived lymphocyte; tool; ubiquination; ubiquitin conjugation; vif Gene Products; vif Protein; viral DNA; virus DNA; virus protein",Revealing the HIV-1 Interactome," PROJECT NARRATIVE  Given the known complexity of biological processes within the cell as well as the rigid constraints imposed by the small coding size of the HIV-1 genome, it is reasonable to expect that the HIV-1 proteome must rely upon a battery of host factor arrays to complete its intracellular tasks. In an effort to recover and identify requisite host proteins that interact in complex with the viral machinery, we have developed a systematic method to select derivatives that can encode a small, but potent, foreign epitope tag yet remain fully replication-competent in culture. In conjunction with a novel cryogenic methodology to capture and preserve transient viral-host interactions, we have recovered and identified new sets of host proteins existing at the viral/host interface (in association with HIV-1 but previously obscured from conventional scientific investigation), a subset of which may have the potential to provide a new targets for small molecule intervention against this virus.",81615,ADDT,AIDS Discovery and Development of Therapeutics Study Section,,2,451688,
7763829,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI081725-02,,NIAID:544340;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"EHRT, SABINE ;",6790899;,5R01AI081725,03/01/2009,02/28/2014,"4-ethoxymethylene-2-phenyl-2-oxazoline-5-one; Acids; Affect; Attenuated; Bacteria; Biology; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chronic; Chronic Phase; Complex; Cytosol; Death; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistant Tuberculosis; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Drugs; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enzymes; Ester Hydrolase; Esteroproteases; Extreme drug resistant tuberculosis; Extremely drug resistant tuberculosis; Gene Expression; Goals; H+ element; High Throughput Assay; Host Defense Mechanism; Hydrogen Ions; IFN; In Vitro; Infection; Interferons; Intracellular Communication and Signaling; Killings; Libraries; Lipids; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Mammals, Mice; Mediating; Medication; Membrane; Mice; Molecular; Mononitrogen Monoxide; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Mycobacterium tuberculosis; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Pathway interactions; Peptidases; Peptide Hydrolases; Phagosomes; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Predisposition; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Protocols, Treatment; Protons; RGM; Regimen; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Serine Endopeptidases; Serine Hydrolase; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stress; Structure; Susceptibility; Testing; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tuberculosis; Tuberculosis, Drug Resistance; Tuberculosis, Drug Resistant; Virulence; Work; XDR-Tuberculosis; acid stress; attenuation; biological signal transduction; cell envelope; chemotherapy; disease/disorder; disseminated TB; disseminated tuberculosis; drug/agent; endothelial cell derived relaxing factor; esterase; experiment; experimental research; experimental study; gene product; high throughput screening; in vivo; inhibitor; inhibitor/antagonist; latent infection; macrophage; macrophage product; membrane structure; multi-drug resistant; multidrug resistant; mutant; novel; pH Homeostasis; pathway; phOx; phOx-one; prevent; preventing; public health relevance; reactive oxygen intermediate; research study; resistant; response; small molecule; tuberculous spondyloarthropathy; wasting",pH Homeostasis in Mycobacterium tuberculosis, Relevance Tuberculosis (TB) is one of the world's most devastating diseases. It is responsible for more than two million deaths and eight million new cases annually. Work outlined in this proposal will investigate virulence mechanisms that allow Mtb to persist within its host and cause disease. It will help identify novel drug targets that might facilitate the development of new drugs against tuberculosis.,81725,HIBP,Host Interactions with Bacterial Pathogens Study Section,,2,544340,
7763931,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI081757-02,,NIAID:470003;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"SALOMON, DANIEL R.;",1884558;,5R01AI081757,02/15/2009,01/31/2014,"3' Untranslated Regions; 3'UTR; Animals; B blood cells; B-Cell Activation; B-Cells; B-Lymphocytes; Back; Binding Proteins; Blast Transformation; Blastogenesis; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD8; CD8B; CD8B1; CD8B1 gene; Cell Function; Cell Lineage; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Cytoplasm; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Degradation, mRNA; Development; Dicer Enzyme; Dorsum; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; ES cell; Enzyme, Dicer; Enzymes; Evolution; Exons; Functional RNA; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Inactivation; Gene Silencing; Gene Targeting; Gene Transcription; Generations; Genes; Genetic Transcription; Genome; Genomics; Heart; Hematopoietic; Human; Human, General; Immune; Immune response; Immunity; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Individual; LYT3; Ligand Binding Protein; Link; Literature; Lymphoblast Transformation; Lymphocyte; Lymphocyte Activation; Lymphocyte Stimulation; Lymphocyte Transformation; Lymphocytic; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Messenger RNA; Methods; Mice; Micro RNA; MicroRNAs; Modeling; Molecular; Murine; Mus; Natural immunosuppression; Non-Coding; Non-Coding RNA; Nucleotides; Nucleus; Organism; Parents; Pathway interactions; Peptide Biosynthesis, Ribosomal; Plant Embryos; Play; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Principal Investigator; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis Inhibition; Protein Synthesis, Ribosomal; Proteins; Proteomics; RNA Expression; RNA, Messenger; Regulation; Review Literature; Role; Sampling; Seeds; Sequence Homologs; Sequences, Homologous; Source; Structure; Subcellular Process; Systems Biology; Targetings, Gene; Testing; Time; Tissues; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Translating; Translatings; Translational Inhibition; Translational Repression; Translations; Transplant Recipients; Transplantation; Transplantation Immunology; Work; Zygotes, Plant; base; biomarker; cardiogenesis; cell type; clinical data repository; clinical data warehouse; data repository; embryonic stem cell; experiment; experimental research; experimental study; gene product; heart development; host response; immunoresponse; immunosuppression; language translation; living system; lymph cell; mRNA; mRNA Expression; mRNA Transcript Degradation; miRNA; next generation; novel; pathway; pri-miRNA; programs; protein synthesis; public health relevance; relational database; research study; seed; social role; stem; stem cell of embryonic origin; tandem mass spectrometry; transcription factor; transplant; transplant patient",MicroRNA regulation of human T and B cell activation," Principal Investigator/Program Director (Last, First, Middle): Salomon, Daniel R. Project Narrative MicroRNAs are a potentially exciting class of cell process regulators that work by inhibiting the synthesis of proteins. Our preliminary results demonstrate that over 60 microRNAs are involved in the activation of human lymphocytes during immune activation. The objective of the present work is to apply a multi-dimensional systems biology or ""omic"" approach including gene profiling, proteomics and Next Generation sequencing to understanding the mechanisms and pathways regulated by microRNAs in the human immune response. The challenge is to develop and validate new strategies that can reduce the current complexity of gene expression and proteomic data, back down to discrete molecular networks and validate these in hypothesis- driven, mechanism-based experiments. When this evolution is accomplished, we will have a new understanding of transplantation immunology, discover a new generation of biomarkers and identify the next generation of potential drug targets. PHS 398/2590 (Rev. 04/06) Page Continuation Format Page",81757,TTT,"Transplantation, Tolerance, and Tumor Immunology",,2,470003,
7770832,R01,AI,5,,02/01/2010,01/31/2011,AI-08-012,5R01AI082030-02,,NIAID:409613;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"FLAVELL, RICHARD A;",1887502;,5R01AI082030,02/17/2009,01/31/2014,"Age; Aging; Aging Process; Aging-Related Process; Apoptotic; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Development; Family; Genetic Determinism; Immune; Immune system; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Lymphoid; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mice; Molecular; Murine; Mus; Pb element; Peripheral; Physiologic; Physiological; Production; Proteins; Receptors, Antigen, T-Cell; Regulation; Relative; Relative (related person); Reticuloendothelial System, Thymus; Role; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; T memory cell; T-Cell Receptor; T-Cells; T-Lymphocyte; Thymocyte Development; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; age dependent; age related; aged; biological signal transduction; body system, allergic/immunologic; gene product; genetic determinant; heavy metal Pb; heavy metal lead; interventional strategy; member; memory T lymphocyte; organ system, allergic/immunologic; progenitor; senescent; social role; thymocyte; thymus derived lymphocyte",The role of Bcl-Rambo in thymic involution," Narrative Bcl-Rambo is one of the first proteins described to date, that positively regulates the process of age-related involution of the thymus. With this application we have the opportunity to assess the relative contributions of age-related deficiencies in lymphohematopoietic progenitor function; peripheral or intrathymic signals that regulate involution; and changes in the thymic microenvironment that contribute to the decline in na¨ve immune cell production, differentiation, and function.",82030,ZAI1,Special Emphasis Panel,,2,409613,
7765573,R01,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R01AI082295-02,,NIAID:403128;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW HAVEN,UNITED STATES,PHARMACOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"LOLIS, ELIAS ;",1868545;,5R01AI082295,02/15/2009,01/31/2014,"21+ years old; 3'5'-cyclic ester of AMP; 3-D structure; 3-dimensional structure; 3D structure; AIDS Virus; AMD-3100; AMD3100; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adult; Adverse effects; Agonist; Alleles; Allelomorphs; Anti-HIV Therapy; Antiphosphodiesterases; Astrocytoma, Grade IV; Binding; Binding (Molecular Function); Binding Sites; Biological Function; Biological Process; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Breast Metastasis; CXC-R4; CXCL12; CXCL12 gene; CXCR-4; CXCR4; CXCR4 gene; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; CellLine; Cellular Assay; Cellular Migration; Chemicals; Collaborations; Combining Site; Complex; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cyclic AMP; Cytokines, Chemotactic; D2S201E; Defect; Disease; Disease model; Disorder; Embryo Development; Embryogenesis; Embryonic Development; Encephalon; Encephalons; FB22; Future; G Protein-Complex Receptor; G Protein-Coupled Receptor Genes; G-Protein-Coupled Receptors; GPCR; GPR; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Glioblastoma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; HIV-1; HIV-I; HIV1; HM89; HSY3RR; Heart; Herpesviridae; Herpesviruses; High Throughput Assay; History; Homologous Chemotactic Cytokines; Human; Human immunodeficiency virus 1; Human, Adult; Human, General; Immunodeficiency Virus Type 1, Human; Immunosuppressants; Immunosuppressive Agents; In Vitro; Infection; Intercrines; Intracellular Communication and Signaling; LAP3; LCR1; LESTR; Length; Letters; Leukemia, Lymphocytic; Libraries; Ligands; Location; Lymphoblastic Leukemia; Lymphoid Leukemia; MIF receptor; MMIF receptors; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Cancer to the Breast; Metastatic Neoplasm; Metastatic Neoplasm to the Breast; Metastatic Tumor; Metastatic Tumor to the Breast; Mice; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Mutate; Mutation; N-terminal; NH2-terminal; NPY3R; NPYR; NPYRL; NPYY3R; Neoplasm Metastasis; Neoplasm Transplantation; Nervous System, Brain; Orphan; PBSF; PDE; Peptides; Phosphodiesterase Antagonists; Phosphodiesterase Inhibitors; Phosphodiesterases; Phosphoric Diester Hydrolase Inhibitors; Physiologic; Physiological; Play; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Proteins; Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-; Reactive Site; Reagent; Receptor Protein; Recording of previous events; Regulation; Reporting; Role; Rolipram; S cerevisiae; SCYB12; SDF-1A; SDF-1B; SDF1; SDF1A; SDF1B; SIS cytokines; Saccharomyces cerevisiae; Schools, Medical; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Site; Source; Specificity; Stress; Structure; Syndrome; System; System, LOINC Axis 4; TLSF-A; TLSF-B; TPAR1; Therapeutic Effect; Tissue Growth; Treatment Side Effects; Tumor Cell Migration; Universities; Washington; Work; X Ray Crystallographies; X-Ray Crystallography; Yeast, Baker's; Yeast, Brewer's; Yeasts; adenosine 3'5' monophosphate; adult human (21+); analog; biological signal transduction; cAMP; cancer metastasis; cell motility; chemoattractant cytokine; chemokine; chemokine receptor; cultured cell line; design; designing; disease/disorder; disorder model; drug development; effective therapy; experiment; experimental research; experimental study; extracellular; gastrointestinal; gene product; genome mutation; glioblastoma multiforme; herpes virus; high throughput screening; human T cell leukemia virus III; human T lymphotropic virus III; immunosuppressive; in vivo; inhibitor; inhibitor/antagonist; insight; interest; lymphatic leukemia; lymphogenous leukemia; macrophage; macrophage migration inhibitory factor receptor; malignancy; medical schools; member; migration; mouse model; mutant; neoplasm/cancer; novel; ontogeny; phosphoric diester hydrolase; prevent; preventing; protein function; public health relevance; receptor; receptor binding; research study; response; side effect; small molecule; social role; spongioblastoma multiforme; success; therapy adverse effect; therapy, AIDS anti-HIV; three dimensional structure; treatment adverse effect; tumor; tumor transplant; tumor transplantation; tumors in the brain; vMIP-II",Regulation of CXCR4 by cognate and non-cognate ligands," PROJECT NARRATIVE The G-protein coupled receptor CXCR4 is involved in the metastasis and growth of several cancers, serves as one of two major co-receptors for HIV-1, and, when mutated at the C-terminus, is partly responsible for the immunosuppressive disorder known as WHIM syndrome. This proposal seeks to understand the mechanism by which proteins function as agonists or antagonists of CXCR4 and the effects that small molecules inhibitors of these proteins have on these functions and on CXCR4.",82295,MSFE,Macromolecular Structure and Function E Study Section,,2,403128,
7771631,R01,AI,5,,03/01/2010,02/28/2011,PA-07-070,5R01AI082376-02,,NIAID:398554;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BERKELEY,UNITED STATES,GENETICS,09,078576738,US,CA,947208202,UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB,"RUBIN, EDWARD M;",1874634;,5R01AI082376,03/01/2009,02/28/2013,"Acinetobacter baumannii; Americas; Anabolism; Anti-Bacterial Agents; Anti-microbial Drug Resistance; Anti-microbial Drug Resistant; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antimicrobial Drug Resistance; Antimicrobial Drug Resistant; Antimicrobial resistant; Assay; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial resistant; Bioassay; Biologic Assays; Biological Assay; Blotting, Northern; Buffers; C. albicans; C.albicans; Candida albicans; Candidate Disease Gene; Candidate Gene; Cells; Characteristics; Chemicals; Chimp; Chimpanzee; Clinic; Clinical; Cloning; Code; Coding System; Communicable Diseases; Communities; DNA; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Deoxyribonucleic Acid; Digestion; Disease; Disorder; Drug Resistance, Microbial; E coli; EC 2.1.1; Enterococcus faecium; Escherichia coli; Functional RNA; Funding; Gene Cluster; Gene Products, RNA; Gene Transcription; Generations; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genome; Genomics; High Throughput Assay; In Vitro; Incubated; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infrastructure; Intercistronic Region; Investigators; K. pneumoniae; Klebsiella pneumonia bacterium; Klebsiella pneumoniae; Marketing; Methicillin Resistance; Methods; Methyltransferase; Microfluidic; Microfluidics; Microorganisms, General; Miscellaneous Antibiotic; Modification; Molecular; Molecular Weight; Mutate; Mutation; Non-Coding; Non-Coding RNA; Northern Blotting; Northern Blottings; Operon; P. aeruginosa; P.aeruginosa; Pan; Pan Genus; Pan Species; Pathway interactions; Pattern; Peptide Biosynthesis, Ribosomal; Peptides; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Public Domains; Public Health; RNA; RNA Expression; RNA blot analysis; RNA blotting; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Reagent; Regions, Intergenic; Research Infrastructure; Research Personnel; Researchers; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; S. faceium; S. faecium; S.faceium; S.faecium; SEQ-AN; Sampling; Screening procedure; Sequence Analyses; Sequence Analysis; Site; Societies; Streptococcus faceium; Streptococcus faecium; Structure; Testing; Toxic effect; Toxicities; Transcript; Transcription; Transcription, Genetic; Translations; anti-bacterial; anti-microbial; anti-microbial agent; anti-microbial drug; antibacterial; antibiotic resistant; antimicrobial; antimicrobial agent; antimicrobial drug; antimicrobial peptide; bacterial resistance; bactericidal; bactericide; base; biosynthesis; clinical data repository; clinical data warehouse; clinical relevance; clinically relevant; comparative genomics; cost; data repository; design; designing; disease/disorder; drug development; enzyme activity; experiment; experimental research; experimental study; gene discovery; gene function; gene product; genome mutation; genome of microbes; genome sequencing; high throughput screening; methicillin resistant; methylase; microbial; microbial drug resistance; microbial drug resistant; microbial genome; microorganism; miniaturize; mutant; nano litre; nanoliter; nanolitre; new approaches; novel; novel approaches; novel strategies; novel strategy; overgrowth bacterial; pathogen; pathway; protein synthesis; public health medicine (field); public health relevance; relational database; research study; resistance to Bacteria; resistance to Bacterial; resistant; resistant to Bacteria; resistant to Bacterial; restriction enzyme; reverse transcriptase PCR; screening; screenings; transmethylase",Pan Genomic Discovery of Genes Toxic to Bacteria, Relevance to public health: The rapid spread of antibiotics resistance among disease-causing bacteria forms a threat to public health. This proposal presents a new approach that facilitates the discovery of thousands of genes that are toxic to bacteria. This approach will be used to detect and develop new antimicrobial agents as well as study a new class of RNA molecules that are toxic to bacteria.,82376,ZRG1,Special Emphasis Panel,,2,398554,
7783823,R01,AI,5,,03/01/2010,02/28/2011,PAR-07-184,5R01AI084657-02,,NIAID:428585;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HUANG, CHRISTENE A;",1903123;,5R01AI084657,03/15/2009,02/28/2014,"0-11 years old; Ablation; Abscission; Advanced Development; Affinotoxins; Animals; Aplastic Anemia; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Cells; Blood Diseases; Blood leukocyte; Body Tissues; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Transplantation; Cell-Mediated Cytolysis; Cell-Mediated Lympholysis; Cells; Cellular Cytotoxicity; Child; Child Youth; Children (0-21); Ciclosporin; Clinic; Clinical; Co-culture; Cocultivation; Coculture; Coculture Techniques; CsA; Cyclosporin A; Cyclosporine; Cyclosporine A; Cytotoxicity, Immunologic; Cytotoxin-Antibody Conjugates; Data; Development; Disease; Disorder; Dose; Engraftment; Ensure; Excision; Extirpation; FLR; Failure (biologic function); Family suidae; GVHD; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic; Genetic Condition; Genetic Diseases; Genetic Intervention; Goals; Graft-Versus-Host Disease; Graft-vs-Host Disease; Hematologic Cancer; Hematologic Diseases; Hematologic Malignancies; Hematologic Neoplasms; Hematological Disease; Hematological Disorder; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Cancer; Hemoglobinopathies; Hemoglobinopathies / Iron Metabolism; Hereditary; Hereditary Disease; Homologous Wasting Disease; Human; Human, Child; Human, General; ITX; Immune; Immune response; Immune system; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Immunologically Directed Therapy; Immunomodulation; Immunotherapy; Immunotoxins; In Vitro; Infection; Infusion; Infusion procedures; Inherited; Intervention, Genetic; Investigators; Laboratories; Leukapheresis; Leukocytapheresis; Leukocytes; Life; Lymphocyte; Lymphocyte Cytotoxicity; Lymphocytic; Lymphocytotoxicity; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Hematologic Neoplasm; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow leukocyte; Miniature Swine; Minipigs; Modeling; Molecular Biology, Gene Therapy; Molecular Disease; Monoclonal Antibody-Toxin Conjugates; Mother Cells; OKT3 antigen; Outcome; PBMC; Parents; Peripheral Blood Cell; Peripheral Blood Mononuclear Cell; Pigs; Population; Pre-Clinical Model; Preclinical Models; Procedures; Progenitor Cells; Protocol; Protocols documentation; Radiation, Whole-Body; Receptors, Antigen, T-Cell; Regulatory T-Lymphocyte; Removal; Research; Research Personnel; Researchers; Reticuloendothelial System, Leukocytes; Rodent; Rodentia; Rodentias; Role; Runt Disease; Sandimmun; SangCya; Stem cells; Suidae; Surgical Removal; Swine; Swine, Miniature; T-Cell Depletion; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T3 Antigens; T3 Complex; T3 molecule; Testing; Therapeutic Leukopheresis; Therapy, DNA; Thymus-Dependent Lymphocytes; Tissues; Total Body Irradiation; Toxic effect; Toxicities; Toxin-Antibody Conjugates; Toxin-Antibody Hybrids; Translating; Translatings; Translations; Transplantation Tolerance; White Blood Cells; White Cell; Whole-Body Irradiation; base; blood disorder; body system, allergic/immunologic; cell mediated cytotoxicity; cell sorting; children; conditioning; disease/disorder; failure; gene therapy; genetic disorder; genetic therapy; graft function; hereditary disorder; host response; hypoimmunity; immune deficiency disorder; immune modulation; immune therapy; immunodeficiency; immunologic reactivity control; immunoregulation; immunoresponse; in vivo; inborn lysosomal enzyme disorder; innovate; innovation; innovative; language translation; leukemia/lymphoma; lymph cell; lymphoma/leukemia; mini pig; neoral; novel; organ system, allergic/immunologic; peripheral blood; porcine; pre-clinical; preclinical; resection; response; sandimmune; social role; suid; thymus derived lymphocyte; white blood cell; white blood corpuscle; youngster","Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy", Toxicities and complications associated with hematopoietic cell transplantation (HCT) currently limit this curative therapy for genetic blood disorders in the clinic. The goal of this proposal is to understand the immunological mechanisms responsible for facilitating high-level haploidentical (e.g. parent into child) donor hematopoietic cell engraftment without complications. The long-term goal of these studies is to translate promising non-toxic HCT protocols using parental donors to replace diseased blood cells and cure genetic blood disorders in children.,84657,ZHD1,Special Emphasis Panel,,2,428585,
7758192,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR041135-17,,NIAMS:380488;OD:41000;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,PEDIATRICS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"DIETZ, HARRY C;",1868082;,5R01AR041135,03/15/1992,01/31/2011,"2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol; ANG-(1-8)Octapeptide; Adrenergic Antagonists; Adrenergic Blockaders; Adrenergic Blockers; Adrenergic Receptor Blockaders; Adrenergic-Blocking Agents; Adrenolytic Agents; Adrenolytic Drugs; Adrenolytics; Alleles; Allelomorphs; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Animal Model; Animal Models and Related Studies; Animals; Anti-Adrenergics; Antiadrenergic Agents; Antiadrenergics; Aorta; Assay; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Bone; Bone and Bones; Bone-Derived Transforming Growth Factor; Bones and Bone Tissue; CSBP1; CSBP2; CSPB1; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Culture System; Cell Signaling; Cells; Cessation of life; Clinical; Cognitive Discrimination; Connective Tissue Diseases; Connective Tissue Disorder; DNA Molecular Biology; Data; Death; Defect; Development; Discrimination; Discrimination (Psychology); Disease; Disorder; Dose; EXIP; Evaluation; Event; FBN1; Family; Fibroblasts; Foundations; GFAC; GWAS; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heterozygote; Histologic; Histologically; Intracellular Communication and Signaling; Investigators; JNK; JNK1; JNK1A2; JNK21B1/2; Link; Losartan; Lung; MAP Kinase 8 Gene; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; Mammals, Mice; Maps; Marfan Syndrome; Mice; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Milk Growth Factor; Missense Mutation; Modeling; Molecular; Molecular Biology; Mothers Against Decapentaplegic Homolog; Murine; Mus; Muscle, Skeletal; Muscle, Voluntary; Mutation; Mutation, Missense; Mxi2; Nature; Organ System, Cardiovascular; Output; PRKM14; PRKM15; PRKM8; Pathway interactions; Patients; Pedigree; Performance; Phenotype; Phosphorylation; Platelet Transforming Growth Factor; Protein Phosphorylation; Proteins; Racial Segregation; Receptor Antagonists, Adrenergic; Receptor Protein; Research Personnel; Researchers; Respiratory System, Lung; Rupture; Ruptured Aortic Aneurysms; SAPK1; SAPK2A; SNP genotyping; Severities; Severity of illness; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Sma- and Mad-Related Proteins; Smad Proteins; Smad protein; Stress; Syndrome; TGF B; TGF-beta; TGFbeta; Therapeutic; Tissues; Transforming Growth Factor beta; Transgenic Organisms; Variant; Variation; Vascular, Heart; Work; base; beta-adrenergic receptor; biological signal transduction; bone; circulatory system; clinical relevance; clinically relevant; comparative efficacy; density; disease severity; disease/disorder; early childhood; epithelial to mesenchymal transition; experiment; experimental research; experimental study; fibrillin-1; gene product; genetic pedigree; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hemodynamics; homologous recombination; in vivo; inhibitor; inhibitor/antagonist; lozartan; model organism; mouse model; mutant; neutralizing antibody; novel; overexpression; p38; p38 MAPK Gene; p38Alpha; pathway; pedigree structure; protective effect; pulmonary; receptor; research study; segregation; skeletal; transgenic; whole genome association studies; whole genome association study",Molecular Biology of Marfan Syndrome,,41135,GHD,Genetics of Health and Disease Study Section,,17,421488,
7760174,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR042238-16,,NIAMS:359741;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BOSTON,UNITED STATES,,08,071723084,US,MA,02215,JOSLIN DIABETES CENTER,"GOODYEAR, LAURIE J;",1899285;,5R01AR042238,09/01/1993,01/31/2014,"21+ years old; ATP-protein phosphotransferase; Adipocytes; Adipose Cell; Adult; Affinity; Autoregulation; Award; Body Tissues; Ca(2+)-Calmodulin Dependent Protein Kinase; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium/calmodulin-dependent protein kinase; Calmodulin; Calmodulin-Dependent Protein Kinases; Calmodulin-Kinase; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Cell membrane; Complex; Contracting Opportunities; Contracts; Cytoplasmic Membrane; D-Glucose; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Distal; Drug Design; EC 2.7; Event; Exercise; Exercise, Physical; Family; Fat Cells; GLUT4; GLUT4 gene; Gene Transfer; Genetic Alteration; Genetic Change; Genetic defect; Glucose; Goals; Heart Diseases; Homeostasis; Human, Adult; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; Kinases; Knockout Mice; Laboratories; Lipids; Lipocytes; METBL; MODY; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Movement; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Mutagenesis, Site-Directed; Mutation; NIDDM; Nature; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; PKC; Pathology; Pathway interactions; Peripheral; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Preventive Medicine; Protein Isoforms; Protein Kinase; Protein Kinase C; Protein Phosphorylation; Proteins; Public Health; Regulation; Research Design; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Skeletal Muscle Tissue; Skeletal muscle structure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Study Type; T2D; T2DM; Targeted DNA Modification; Targeted Modification; Testing; Tissues; Transphosphorylases; Type 2 diabetes; Type II diabetes; VESCL; Vesicle; Work; adult human (21+); adult onset diabetes; atypical protein kinase C; base; biological signal transduction; body movement; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; design; designing; diabetes; disease/disorder; gene product; genome mutation; glucose metabolism; glucose transport; glucose uptake; glycogen synthase a kinase; heart disorder; hydroxyalkyl protein kinase; improved; in vivo; inhibitor; inhibitor/antagonist; insulin resistant; ketosis resistant diabetes; maturity onset diabetes; member; microtubule associated protein 2 kinase; mouse model; muscle metabolism; novel; overexpression; pathway; phosphorylase b kinase kinase; plasmalemma; prevent; preventative medicine; preventing; protein kinase II; public health medicine (field); public health relevance; response; social role; study design; transfer of a gene; upstream kinase",Exercise and Skeletal Muscle Signaling Mechanisms," PROJECT NARRATIVE Studies designed to understand how exercise alleviates the insulin resistance associated with type 2 diabetes is relevant to public health because type 2 diabetes is pervading virtually every demographic subset, with conspicuous and alarming affinity for younger individuals. Fortunately, physical exercise represents a cornerstone therapy to prevent or improve diabetes and its related pathologies. The goal of this proposal is to determine the molecular basis for these beneficial effects in exercising muscles, which may then be used to develop breakthrough drugs designed to treat diabetes.",42238,ZRG1,Special Emphasis Panel,,16,359741,
7787017,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR043052-11,,NIAMS:669722;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"LANE, NANCY E.;",1868776;,5R01AR043052,05/01/1995,01/31/2014,"65+ years old; Affect; After Care; After-Treatment; Aftercare; Aging; Anabolic Agents; Animals; Biochemical; Biochemical Markers; Body Tissues; Body of vertebra; Bone; Bone Matrix; Bone Mineralization; Bone Tissue; Bone and Bones; Bone remodeling; Bones and Bone Tissue; Calcification, Physiological; Change of Life, Female; Clinical Medicine; Common Rat Strains; Data; Deterioration; Drugs; Egg, Unfertilized; Estrogenic Agents; Estrogenic Compounds; Estrogens; Fracture; Fracture due to osteoporosis; Genital System, Female, Fluids, Secretions, Ova; Human; Human Parathyroid Hormone (1-34); Human, General; Intervention; Intervention Strategies; Longitudinal Studies; Mammals, Rats; Man (Taxonomy); Man, Modern; Markers, Biochemical; Measures; Medical Sciences, Clinical; Medication; Menopause; Metaphysis; Osteoporosis; Osteoporosis with fracture; Osteoporotic fracture; Ova, Fluids, Secretions; Ovum; Parathyroid Hormone Peptide (1-34); Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic calcification; Property; Property, LOINC Axis 2; Proteins; Protocols, Treatment; Public Health; RGM; Rat; Rat-1; Rat-1 Cells; Rattus; Regimen; Reporting; Research; Scanning; Secondary to; Senescence; Structure; Surface; Syndrome; Teriparatide; Testing; Therapeutic Estrogen; Time; Tissues; Treatment Protocols; Treatment Regimen; Treatment Schedule; Vertebral Body; Withdrawal; Withdrawing Treatments; Work; base; bone; bone fracture; bone geometry; bone mass; bone quality; bone remodelling; bone strength; bone turnover; drug/agent; egg/ovum; experience; experiment; experimental research; experimental study; gene product; hPTH (1-34); human old age (65+); improved; in vivo; interventional strategy; long-term study; menopausal; mineralization; morphometry; older women; osteoporosis with pathological fracture; preclinical study; prevent; preventing; public health medicine (field); public health relevance; research study; senescent; skeletal; substantia spongiosa; substantia trabecularis; trabecular bone; vertebra body",3D in vivo morphometry of trabecular microstructure, 7. PROJECT NARRATIVE At least one third of women older than 65 years will experience an osteoportic fracture. This research has direct relevance to public health by providing data that will guide clinicians in prescribing osteoporosis medication to maximize bone strength and the durability of their effects.,43052,SBSR,Skeletal Biology Structure and Regeneration Study Section,,11,669722,
7771684,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR043510-15,,NIAMS:341736;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,ROCHESTER,UNITED STATES,PATHOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"BOYCE, BRENDAN F;",1895652;,5R01AR043510,06/01/1995,01/31/2014,"Affect; Albers-Schoenberg Disease; Albers-Schonberg disease; Animal Disease Models; Arthritis; Articulation; Atrophic Arthritis; Blood Precursor Cell; Bone; Bone Diseases; Bone Marrow; Bone Resorption; Bone and Bones; Bones and Bone Tissue; CCND1 Protein; Cell Communication and Signaling; Cell Signaling; Cells; Complex; Cyclin D1; DIF; Data; Development; Disease; Disorder; EC 2.7; FOS gene; G0S7; G1/S-Specific Cyclin D1; Hematopoietic stem cells; INFLM; In Vitro; Inflammation; Inflammatory; Inflammatory Arthritis; Intracellular Communication and Signaling; Joints; Kinases; Knee joint; Knockout Mice; Lead; Mammals, Mice; Marble Bone Disease; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Murine; Mus; Null Mouse; ODF; OPGL; Osteoblasts; Osteoclastic Bone Loss; Osteoclasts; Osteopetrosis; Osteoporosis, Post-Menopausal; Osteoporosis, Postmenopausal; Osteosclerosis Fragilis; PRAD1 Protein; Pathologic; Pathway interactions; Pattern; Pb element; Perimenopausal Bone Loss; Phenotype; Phosphotransferases; Play; Postmenopausal Bone Loss; Postmenopausal Osteoporosis; Process; Progenitor Cells, Hematopoietic; Proteins; Proto-Oncogene Proteins c-bcl-1; Protooncogene FOS; RANKL; Reticuloendothelial System, Bone Marrow; Rheumatoid Arthritis; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Synovitis; TNF; TNF A; TNF gene; TNFSF11; TNFSF11 gene; TNFSF2; Testing; Transgenic Organisms; Transphosphorylases; Tumor Necrosis Factor Gene; arthritic; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; bone; bone cell; bone disorder; bone loss; c fos; c-bcl-1 Proteins; c-fos Gene; c-fos Proto-Oncogenes; cyclin D; cytokine; disease/disorder; gene product; hRANKL2; heavy metal Pb; heavy metal lead; in vivo; loss of function; marble bone; member; novel; novel therapeutic intervention; p65; pathway; prevent; preventing; public health relevance; response; sOdf; social role; transcription factor; transgenic; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Studies of the Fate of the Osteoclast," Narrative Osteoclasts are the cells that degrade bone and over-activity of them causes bone loss in common diseases, such as rheumatoid arthritis. Our proposed studies, using animal models of these diseases, should lead to a better understanding of how osteoclast activity is regulated and eventually to the development of a novel therapy to limit this activity in these bone disorders.",43510,SBSR,Skeletal Biology Structure and Regeneration Study Section,,15,341736,
7760613,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR044684-12,,NIAMS:357192;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"CASCIOLA-ROSEN, LIVIA A;",1864048;,5R01AR044684,09/30/1997,01/31/2013,"ATGN; Address; Antibodies; Antigen Targeting; Antigens; Antigens, Differentiation; Assay; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; Autologous Antigens; Bioassay; Biologic Assays; Biological Assay; Biopsy; Blood Serum; Body Tissues; Cells; Cellular injury; Cleaved cell; Data; Dermatomyositis; Dermatomyositis, Juvenile; Dermatopolymyositis; Development; Diagnosis; Diagnostic; Diagnostic Sensitivity; Differentiation Antigens; Differentiation Markers; Disease; Disease by Site; Disease model; Disorder; Disorder by Site; Disorder of muscle, unspecified; Goals; Granzyme; Immune; Immune Targeting; Immune response; Immune system; Immunoblotting; In Situ; Individual; Inflammatory Myopathy; Lymphocyte; Lymphocytic; Lytotoxicity; Marker Antigens; Markers, Differentation; Mediating; Muscle; Muscle Cells; Muscle Cells, Embryonic; Muscle Cells, Mature; Muscle Cells, Precursor; Muscle Disease; Muscle Diseases, Inflammatory; Muscle Disorders; Muscle Tissue; Muscle disease or syndrome; Muscular Diseases; Musculoskeletal Pain Disorder; Myoblasts; Myocytes; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myositis; Natural regeneration; Pathologic; Pathway interactions; Patients; Pattern; Phase; Phenotype; Polymyositis-Dermatomyositis; Prevention; Programs (PT); Programs [Publication Type]; Regeneration; Research; Research Design; Rheumatic Diseases; Rheumatism; Role; Self-Antigens; Sensitivity and Specificity; Serum; Shapes; Site; Source; Specificity; Staging; Study Type; Tissues; To autoantigen; autoimmune antibody; body system, allergic/immunologic; cell damage; cell injury; cell type; cleaved; cohort; cytotoxic; cytotoxic serine protease B; cytotoxicity; design; designing; disease diagnosis; disease phenotype; disease/disorder; disorder model; expression cloning; fragmentin 2; granzyme B; host response; human disease; immunogen; immunoresponse; in vivo; insight; lymph cell; muscle regeneration; muscular disorder; new diagnostics; next generation diagnostics; novel; novel diagnostics; novel marker; organ system, allergic/immunologic; pathway; programs; regenerate; repair; repaired; response; self reactive antibody; self recognition (immune); social role; study design",Rheumatic Disease Sera: Probes of Disease Mechanisms,,44684,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,12,357192,
7761734,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR046122-10,,NIAMS:261136;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"CHANG, LIN ;",3076363;,5R01AR046122,09/13/1999,01/31/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; ACTH; ACTH (1-39); ACTH-Releasing Factor; ADRGND; Abdomen; Abdominal; Abdominal Pain; Aching muscles; Address; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Affect; Allergy; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anterior; Anxiety; Area; Arousal; Attention; Bed Nucleus of Stria Terminalis; Behavior; Behavioral; Biological Factors; Body Tissues; Brain; Brain Stem; Brain region; Brainstem; CRF-41; CRH; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Central Nervous System; Central gray substance of midbrain; Cerebrospinal Fluid; Cetacort; Characteristics; Chemotherapy-Hormones/Steroids; Chronic; Circadian Rhythms; Circulatory Collapse; Clinical; Cognitive; Colitis, Mucous; Colon, Irritable; Cort-Dome; Cortef; Cortenema; Corticoliberin; Corticotropin; Corticotropin (1-39); Corticotropin Releasing-Factor Receptors; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Corticotropin-Releasing Hormone-41; Cortisol; Cortispray; Cortril; Cues; Data; Defecation; Dermacort; Diagnostic; Diffuse Myofascial Pain Syndrome; Disease; Disorder; Diurnal Rhythm; Dorsal; Dysfunction; Eldecort; Emotional; Encephalon; Encephalons; Endocrine Gland Secretion; Esthesia; Euler-Gaddum Substance P; Factor, Biologic; Fatigue; Fear; Feedback; Female; Fibromyalgia; Fibromyositis-Fibromyalgia Syndrome; Fibrositis; Fright; Functional disorder; Funding; Goals; HPA; Habits; Hormones; Hydrocortisone; Hydrocortone; Hyperalgesia; Hyperalgesic Sensations; Hypersensitivity; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Irritable Bowel Syndrome; Laboratories; Laboratory Study; Lack of Energy; Lateral; Left; Levarterenol; Levonorepinephrine; Locus Coeruleus; Lumbar Puncture; MPD syndrome; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesencephalic Central Gray; Midbrain Central Gray; Modeling; Motor; Muscle; Muscle Tissue; Muscle discomfort; Muscle pain; Muscle pain/fibrositis; Muscle sorenesss; Myalgia; Myalgia unspecified; Myalgic; Myodynia; Myoneuralgia; Myosalgia; Natural Products; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Nervous System, Pituitary; Neural Cell; Neuraxis; Neurobiology; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Noradrenaline; Norepinephrine; Nucleus; Nucleus Pigmentosus Pontis; Nucleus Tractus Solitarii; Nucleus solitarius; Nutracort; Nyctohemeral Rhythm; Outcome Measure; Pain; Pain Disorder; Pain Threshold; Pain Tolerance Level; Painful; Pathway interactions; Patient Self-Report; Patients; Pattern; Peptides; Perception; Periaqueductal Gray; Physiologic; Physiological; Physiopathology; Pituitary; Pituitary Gland; Play; Prefrontal Cortex; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pressure; Pressure- physical agent; Principal Investigator; Process; Proctocort; Programs (PT); Programs [Publication Type]; Questionnaires; Receptor Protein; Receptors, CRF; Receptors, CRH; Receptors, Corticotropin-Releasing Hormone; Recurrence; Recurrent; Research Personnel; Researchers; Rheumatism, Muscular; Role; SNS; SP(1-11); Self-Report; Sensation; Sensory; Shock; Sigmoid; Sigmoid colon; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sleep; Solitary Nucleus; Specificity; Spinal Puncture; Stimulus; Stress; Stressful Event; Stria Terminalis Nucleus; Striatum, Ventral; Structure; Structure of locus ceruleus; Structure of terminal stria nuclei of preoptic region; Substance P; Sympathetic Nervous System; Symptoms; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Hormone; Therapeutic Hydrocortisone; Tissues; Twenty-Four Hour Rhythm; Ventral Striatum; Ventral Tegmental Area; Viscera; Visceral; Walkers; Work; amygdaloid nuclear complex; annulus of the aqueduct; basal forebrain; base; behavior influence; behavior test; behavioral influence; behavioral test; biological adaptation to stress; biological signal transduction; blue nucleus; bowel; bowel movement; cingulate cortex; circadian; circadian process; circulatory shock; colorectal distension; corticotropin releasing hormone; daily biorhythm; disease/disorder; diurnal variation; effective therapy; experience; fibromyalgia syndrome; gastrointestinal; health related quality of life; hyperalgia; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; locus ceruleus structure; mechanical pressure; meetings; midbrain central gray substance; motivated behavior; myofascial pain dysfunction syndrome; neurobiological; neurokinin 1; neuronal; noradrenergic; pain tolerance; pathophysiology; pathway; patient population; periaqueductal gray matter; pressure; programs; psychosocial; reaction; crisis; receptor; rectal; response; sex; social role; solitary tract nucleus; spastic colon; spinal fluid; stress response; stress; reaction; stressor; suprarenal gland; ventral tegmentum; vigilance",Neuroendocrine Alterations in Fibromyalgia and IBS,,46122,ZRG1,Special Emphasis Panel,,10,261136,
7758315,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR046238-10,,NIAMS:320207;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"WERB, ZENA ;",1873471;,5R01AR046238,09/01/1999,01/31/2011,"21+ years old; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Ablation; Adult; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Biochemical; Blood Vessels; Body Tissues; Bone; Bone Development; Bone Formation; Bone Marrow; Bone and Bones; Bone remodeling; Bones and Bone Tissue; Calcified; Cartilage; Cartilagenous Tissue; Cell Death; Cell Death, Programmed; Cell-Extracellular Matrix; Cells; Cellular Expansion; Cellular Growth; Cessation of life; Chondrocytes; Coupled; Death; Defect; Deposit; Deposition; Development; Differentiation and Growth; ECM; Endothelial Cells; Environment; Enzymes; Epiphyseal Plate; Epiphysial cartilage; Event; Extracellular Matrix; Extracellular Matrix Proteins; Feeds; Fracture; Fracture Healing; Funding; Gelatinase B; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Growth Plate; HTRPY; Healed; Human, Adult; Hypertrophy; Injury; Lesion; Long Bone; MMP-13; MMP-13 gene product; MMP-9; MMP-9 Protein; MMP13 gene product; MMP9; MMPs; Macrophage Gelatinase; Mammals, Mice; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Mechanics; Mediating; Mice; Mice, Mutant Strains; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Morphogenesis; Murine; Mus; Mutant Strains Mice; Mutation; Natural regeneration; Osteoblasts; Osteoclasts; Osteogenesis; Pathway interactions; Physiologic; Physiological; Process; Programs (PT); Programs [Publication Type]; Proliferating; Protein Cleavage; Proteolysis; Proteolytic Regulation; Recruitment Activity; Regeneration; Regulation; Regulation of Proteolysis; Relative; Relative (related person); Rest; Reticuloendothelial System, Bone Marrow; Role; Skeletal Development; Structure of long bone; Therapeutic Intervention; Tissue Growth; Tissues; Transplantation; Type V Collagenase; VEGFs; Vascular Endothelial Growth Factors; Vegf; Wild Type Mouse; adult human (21+); angiogenesis; bone; bone fracture; bone remodelling; cell growth; cell type; collagenase 3; extracellular; genome mutation; healing; insight; intervention development; intervention therapy; intramembranous bone formation; intramembranous ossification; long bone; matrix metalloproteinase-13; mouse mutant; necrocytosis; novel; ontogeny; osteogenic; osteoprogenitor cell; pathway; progenitor; programs; recruit; regenerate; regenerative; repair; repaired; response; skeletal; skeletal injury; skeletal regeneration; social role; substantia spongiosa; substantia trabecularis; therapy development; tool; trabecular bone; transplant; treatment development; vascular",Extracellular remodeling in bone development and repair,,46238,SBSR,Skeletal Biology Structure and Regeneration Study Section,,10,320207,
7760584,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR046905-10,,NIAMS:492822;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN FRANCISCO,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MAJUMDAR, SHARMILA ;",6802167;,5R01AR046905,09/17/1999,01/31/2011,"Accounting; Active Follow-up; Acute; Address; Adipocytes; Adipose Cell; Anterior Cruciate Ligament; Architecture; Arthritis; Arthritis, Degenerative; Arthroplasty, Replacement, Knee; Articulation; Biochemical; Bleeding; Body Tissues; Bone; Bone Marrow; Bone and Bones; Bone structure of tibia; Bones and Bone Tissue; Bruise; Cartilage; Cartilage Matrix; Cartilage, Articular; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Characteristics; Collagen; Contralateral; Contrast Agent; Contrast Drugs; Contrast Media; Contusions; Defect; Degenerative polyarthritis; Dropsy; Edema; Engineering / Architecture; Enrollment; Environment; Fat Cells; Fats; Fatty acid glycerol esters; Femur; Gadolinium DTPA; Gadolinium Diethylenetriaminepenta-acetic Acid; Gadopentetic Acid; Gd-DTPA; Grant; H+ element; Hemorrhage; History; Hydrogen Ions; Hydrogen Oxide; Hydrops; Image; Impairment; Injury; Intracellular Communication and Signaling; Investigators; Joints; Knee; Knee Replacement, Total; Knee arthroplasty; Knee joint; Knee joint replacement operation; Knee replacement; Lateral; Lipocytes; Localized Disease; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Marrow; Mature Lipocyte; Mature fat cell; Measurement; Measures; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrana Synovialis Capsulae Articularis; Metric; Morphology; Muscle; Muscle Tissue; NMR Imaging; NMR Tomography; Necrosis; Necrotic; Noise; Nuclear Magnetic Resonance Imaging; Osteoarthritis; Osteoarthrosis; Pain; Painful; Patients; Population Control; Programs (PT); Programs [Publication Type]; Prosthetic total arthroplasty of the knee; Proteoglycan; Protons; Radiopaque Media; Recording of previous events; Relaxation; Research; Research Personnel; Research Specimen; Researchers; Reticuloendothelial System, Bone Marrow; Role; Scanning; Sclerosis; Severities; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Structure; Structure of articular cartilage; Swelling; Symptoms; Synovial Membrane; Synovium; TKR - Total knee replacement; Thick; Thickness; Tibia; Time; Tissues; Total Arthroplasty of the Knee; Water; Weight; Zeugmatography; arthritic; articular cartilage; base; biological signal transduction; blood loss; bone; bone imaging; bone scanning; cohort; degenerative joint disease; disease severity; enroll; experience; follow-up; hypertrophic arthritis; imaging; improved; interest; ligament injury; programs; saturated fat; skeletal imaging; social role; substantia spongiosa; substantia trabecularis; tibia; trabecular bone; uptake",Cartilage-Bone Interactions in Osteoarthritis,,46905,ZRG1,Special Emphasis Panel,,10,492822,
7798103,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR047664-07,,NIAMS:335412;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"VERGARA, JULIO L.;",1881809;,5R01AR047664,04/01/2001,01/31/2014,"21+ years old; 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-; A5 dystrophin-associated protein, human; Action Potentials; Adult; Affect; Animal Model; Animal Models and Related Studies; Animals; Arts; Attenuated; Benign; Buffers; Calsequestrin; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Complex; Coupling; Cranin; Data; Development; Disorder of muscle, unspecified; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Dystroglycan; Dystroglycans; Dystrophin; Dystrophin-Related Protein; Dystrophin-Related Protein 1; EGATA; EGTA; Egtazic Acid; Electric Stimulation; Electrical Stimulation; Electroporation; Ellis-van Creveld (EvC) syndrome; Energy Transfer; Ethylene Glycol Bis(2-aminoethyl ether)tetraacetic Acid; Ethylene Glycol Tetraacetic Acid; Ethylenebis(oxyethylenenitrile)tetraacetic Acid; Fiber; Fluorescence Microscopy; Fostering; Foundations; GEDTA; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Intervention; Genetic defect; Genetics, Other; Glycoletherdiamine-N,N,N',N'-tetraacetic Acid; Glycoproteins; Goals; Hereditary Disease; Human; Human, Adult; Human, General; Impairment; Inbred mdx Mice; Intervention, Genetic; Intracellular Communication and Signaling; Investigation; KRAG; KRAG protein, human; KRAS Oncogene-Associated Protein; Kirsten-RAS Associated Protein; Knock-out; Knockout; Laser Scanning Microscopy; Life; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Membrane; Methods and Techniques; Methods, Other; Mice; Mice, Inbred mdx; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular; Molecular Biology, Gene Therapy; Molecular Disease; Mouse, mdx; Murine; Mus; Muscle; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle Weakness; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Diseases; Muscular Dystrophies; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Muscular Weakness; Mutation; Myodystrophica; Myodystrophy; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotubes; Optical Methods; Optics; Other Genetics; Pathology; Patients; Phenotype; Photons; Physiologic; Physiologic pulse; Physiological; Position; Positioning Attribute; Process; Progressive Muscular Dystrophy, Duchenne Type; Proteins; Pseudohypertrophic Muscular Dystrophy, Childhood; Pulse; Relative; Relative (related person); Rhabdomyocyte; Role; RyR1; SERCA1; SPN1; SPN2; SPN2 protein, human; SSPN; SSPN protein, human; Sarcoglycans; Sarcolemma; Sarcoplasmic Reticulum; Sarcospan; Scanning Microscopy, Laser; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Structure; Surface; System; System, LOINC Axis 4; Techniques; Testing; Tet; Tetanus Helper Peptide; Therapeutic; Therapy, DNA; Transgenic Animals; Transgenic Organisms; Tubular; Tubular formation; UTRN Protein; Utrophin; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; adult human (21+); benign X-linked recessive muscular dystrophy; biological signal transduction; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; experiment; experimental research; experimental study; gene product; gene therapy; genetic disorder; genetic therapy; genome mutation; hereditary disorder; human SSPN protein; in vivo; membrane structure; mild X-linked recessive muscular dystrophy; mini-dystrophin; minidystrophin; model organism; muscular disorder; nano meter scale; nano meter sized; nano scale; nanometer scale; nanometer sized; nanoscale; novel; overexpression; progressive muscular dystrophy of childhood; protein complex; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; public health relevance; research study; response; sarcospan (Kras oncogene-associated gene) protein, human; sarcospan protein, human; sarcospan-1, human; sarcospan-2, human; social role; tool; transgenic; two-photon; voltage clamp",Excitation-Contraction Coupling in Normal and Dystrophic Mammalian Muscle," Relevance Statement In Duchenne Muscular Dystrophy (DMD) the muscles lack the protein dystrophin, an integral component of a dystrophin-glycoprotein complex (DGC). We have discovered that the absence of dystrophin in the muscle fibers of the mdx mouse, a widely used animal model of DMD, impairs their ability to release Ca2+ from the sarcoplasmic reticulum in response to electrical stimulation, thus explaining the muscle weakness observed in the DGC pathology. We now propose to investigate the mechanisms that link DGC alterations with a deficient Ca2+ release. The results will significantly broaden our understanding of muscle disease mechanisms and will potentially provide therapeutic molecular tools which are deemed necessary for further advances in gene therapy. ",47664,ZRG1,Special Emphasis Panel,,7,335412,
7774339,R01,AR,5,,03/01/2010,02/28/2011,,5R01AR051000-05,,NIAMS:288148;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PHILADELPHIA,UNITED STATES,ORTHOPEDICS,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SOSLOWSKY, LOUIS J.;",1883642;,5R01AR051000,03/01/2006,02/28/2011,"Age; Animal Model; Animal Models and Related Studies; Articular Range of Motion; Back; Bgn protein; Bone; Bone Regeneration; Bone and Bones; Bones and Bone Tissue; Cell-Extracellular Matrix; Clinical; Clinical Research; Clinical Study; Collagen; Collagen Fiber; Collagen Type III; Data; Doctor of Medicine; Dorsum; ECM; Environment; Exercise; Exercise, Physical; Extracellular Matrix; FLR; Failure (biologic function); Fiber; Future; Gene Expression; Hand; Healed; Human; Human, General; Immobilization; Incidence; Injury; Investigators; Joint Range of Motion; Lead; M.D.; Man (Taxonomy); Man, Modern; Mechanics; Methods and Techniques; Methods, Other; Modeling; Motion; Operation; Operative Procedures; Operative Surgical Procedures; PG-S1; Passive Range of Motion; Passive Range of Motion function; Patients; Pb element; Physical Health Services / Rehabilitation; Post-Operative; Postoperative; Postoperative Period; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Range of Motion, Articular; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Role; Rotator Cuff; Shoulder; Site; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Tendon structure; Tendons; Time; aggrecan; base; biglycan; bone; bone healing; bone proteoglycan I; bone repair; decorin; failure; healing; heavy metal Pb; heavy metal lead; immobilization of body part; improved; insight; model organism; orthopedic freezing; programs; proteoglycan I; proteoglycan S1; range of motion; rehabilitative; repair; repaired; response; social role; surgery; trend",Rotator cuff tendon to bone insertion site healing,,51000,SBSR,Skeletal Biology Structure and Regeneration Study Section,,5,288148,
7758803,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR051440-05,,NIAMS:234611;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN ANTONIO,UNITED STATES,CHEMISTRY,23,800189185,US,TX,782490600,UNIVERSITY OF TEXAS SAN ANTONIO,"JARRETT, HARRY W;",1922443;,5R01AR051440,02/01/2006,01/31/2011,"AKT; ASV; ASVSRC1; ATP-protein phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Actins; Affect; Akt protein; Anoikis; Antibodies, Blocking; Apoptosis; Apoptosis Pathway; Atrophic; Atrophy; Atrophy, Muscle; Autoregulation; Binding; Binding (Molecular Function); Binding Sites; Blocking Antibodies; Body Regions; CSBP1; CSBP2; CSPB1; Cell Attachment; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell-Extracellular Matrix; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Expansion; Cellular Growth; Cellular Matrix; Cellular Proliferation; Cessation of life; Combining Site; Complex; Contracting Opportunities; Contracts; Cranin; Cytoskeletal System; Cytoskeleton; Death; Defect; Disorder of muscle, unspecified; Dose; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Dysfunction; Dystroglycan; Dystroglycans; Dystrophin; ECM; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EXIP; Ellis-van Creveld (EvC) syndrome; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Event; Extracellular Matrix; Extracellular Matrix, Integrins; FADK; FAK; FAK1; Fiber; Functional disorder; Genes; Genes, c-src; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glycoprotein GP-2; Glycoproteins; HEK3; HTRPY; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Homeostasis; Hypertrophy; Integrin Binding; Integrins; Intracellular Communication and Signaling; Investigation; Investigators; Isoforms; JNK; JNK1; JNK1A2; JNK21B1/2; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Laboratories; Laminin; Lesion; Life; Link; Location; MAP Kinase 8 Gene; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; Measures; Mechanics; Mechanoreceptors; Merosin; Modeling; Molecular Interaction; Motion; Muscle; Muscle Cells; Muscle Cells, Embryonic; Muscle Cells, Mature; Muscle Cells, Precursor; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Muscular Diseases; Muscular Dystrophies; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Mutation; Mxi2; Myoblasts; Myocytes; Myodystrophica; Myodystrophy; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotubes; Nature; PKB protein; PRKM14; PRKM15; PRKM8; PTK; PTK2; PTK2 gene; Pathway interactions; Phosphorylation; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Prevention; Process; Progressive Muscular Dystrophy, Duchenne Type; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase; Protein Kinase B; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein-Tyrosine Kinases, src; Proteins; Proto-Oncogene Proteins c-akt; Pseudohypertrophic Muscular Dystrophy, Childhood; RAC-PK protein; Reactive Site; Receptor Protein; Receptor Signaling; Research Personnel; Researchers; Rhabdomyocyte; Role; SAPK1; SAPK2A; SRC; SRC gene; SRC1; Sarcolemma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Stretching; Sum; Suspension substance; Suspensions; Testing; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; benign X-linked recessive muscular dystrophy; biological signal transduction; c jun; c src; c-akt protein; c-jun Gene; c-src Proto-Oncogenes; cell growth; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; congenital muscular dystrophy; experiment; experimental research; experimental study; gene product; genome mutation; glycogen synthase a kinase; hydroxyalkyl protein kinase; hydroxyaryl protein kinase; inhibitor; inhibitor/antagonist; intracellular skeleton; mild X-linked recessive muscular dystrophy; muscular disorder; necrocytosis; p38; p38 MAPK Gene; p38Alpha; pathophysiology; pathway; phosphorylase b kinase kinase; pp125FAK; prevent; preventing; progressive muscular dystrophy of childhood; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; rac protein kinase; receptor; related to A and C-protein; research study; response; satellite cell; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; suspension; syntrophin; tyrosyl protein kinase; v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog",Muscle Cell Signaling,,51440,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,5,234611,
7759114,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR052326-05,,NIAMS:273575;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,WYNNEWOOD,UNITED STATES,,06,125797084,US,PA,19096,LANKENAU INSTITUTE FOR MEDICAL RESEARCH,"GEORGE-WEINSTEIN, MINDY ;",1890387;,5R01AR052326,04/01/2006,01/31/2011,"21+ years old; Ablation; Abscission; Adhesion Molecule; Adult; BMP-3; BMP-3A; BMP3; Biological Models; Blotting, Western; Body Tissues; Bone Morphogenetic Protein 3; Bone Morphogenetic Protein 3 (Osteogenic); Bone Morphogenetic Proteins; CAM 120/80; Cadherin-1; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell-Cell Adhesion; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Chick Embryo; Co-culture; Cocultivation; Coculture; Coculture Techniques; Commit; Communication; Contractile Proteins; Development; Developmental Biology; Down-Regulation; Down-Regulation (Physiology); Downregulation; E-Cadherin; ES cell; Embryo; Embryonic; Embryonic Tissue; Ensure; Environment; Epiblast; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Event; Excision; Extirpation; Family member; Human, Adult; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Vitro; Label; Lead; Light; Liver Cell Adhesion Molecules; Mediating; Mesoderm; Messenger RNA; Model System; Models, Biologic; Monitor; Mother Cells; Muscle; Muscle Tissue; Muscle satellite cell; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Myocardium; N-Cadherin; Natural regeneration; Organ; Pathway interactions; Pb element; Photoradiation; Play; Pluripotent Stem Cells; Primitive Streaks; Principal Investigator; Process; Progenitor Cells; Publishing; RNA, Messenger; RT-PCR; RTPCR; Recruitment Activity; Regeneration; Regenerative Medicine; Removal; Research; Research Design; Reverse Transcriptase Polymerase Chain Reaction; Role; Signal Pathway; Skeletal Muscle Tissue; Skeletal muscle structure; Somites; Specific qualifier value; Specified; Staging; Stem cells; Streaks, Primitive; Striated Muscle Tissue; Striated Muscles; Study Type; Surgical Removal; Testing; Therapeutic; Tissues; Uvomorulin; Western Blotting; Western Blottings; Western Immunoblotting; Work; adult human (21+); base; bone morphogenic protein 3; cardiac muscle; cell adhesion protein; conditioning; design; designing; embryo tissue; embryonic stem cell; experiment; experimental research; experimental study; heart muscle; heavy metal Pb; heavy metal lead; implantation; in vivo; inhibitor; inhibitor/antagonist; liver cell adhesion molecule; mRNA; member; method development; muscle stem cell; myogenesis; novel; osteogenin; pathway; protein blotting; recruit; regenerate; regenerate new tissue; regenerating damaged tissue; repair; repaired; research study; resection; response; reverse transcriptase PCR; satellite cell; skeletal; social role; stem cell of embryonic origin; study design; tissue regeneration; transcription factor",Directing the Fate of Cells to Myogenic Lineages,,52326,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,5,273575,
7760615,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR052756-05,,NIAMS:302095;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,ANN ARBOR,UNITED STATES,PATHOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"NUNEZ, GABRIEL ;",1881681;,5R01AR052756,04/10/2006,01/31/2011,"Address; Amyloid nephropathy with deafness and urticaria; Apoptosis; Apoptosis Pathway; Autoimmune; Autoimmune Process; Bacteria; Bacterial Infections; Causality; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Disease; Disorder; Etiology; Exhibits; Experimental Models; Experimental Models, Other; Familial amyloid nephropathy with urticaria and deafness; Familial disease; Family member; Fever; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Hereditary; Host Defense; Hyperthermia; INFLM; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Inflammation; Inflammatory; Inherited; Intracellular Communication and Signaling; Invaded; Laboratories; Link; MEFV gene product; Mammals, Mice; Mediating; Mice; Mice, Mutant Strains; Missense Mutation; Modeling; Models, Experimental; Muckle-Wells syndrome; Muckle-Wells type amyloidosis; Murine; Mus; Mutant Strains Mice; Mutation; Mutation, Missense; Natural Immunity; Neonatal; Pathogenesis; Pathway interactions; Patients; Play; Process; Protein Family; Proteins; Pyrexia; Rare Diseases; Rare Disorder; Recurrence; Recurrent; Regulation; Role; Salmonella; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Syndrome; System; System, LOINC Axis 4; TLR4; TLR4 gene; TOLL; UDA Syndrome; Urticaria, deafness and amyloidosis syndrome; Work; autoimmune arthritis; bacterial disease; biological signal transduction; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; familial disorder; febrile; febris; gene product; genome mutation; hToll; host response; immunoresponse; in vivo; insight; macrophage; marenostrin; member; mouse mutant; mutant; novel; pathogen; pathway; pyrin; response; social role",Role of ASC signaling Pathway in Inflammatory Disease,,52756,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,302095,
7761687,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR052779-05,,NIAMS:356270;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LA JOLLA,UNITED STATES,,53,020520466,US,CA,92037,BURNHAM INSTITUTE FOR MEDICAL RESEARCH,"PURI, PIER LORENZO;",7717930;,5R01AR052779,04/20/2006,01/31/2011,"Acetylation; Acetyltransferase; Age; Agents, Cytostatic; Antibodies; Binding Proteins; CREBBP-Associated Factor; CSBP1; CSBP2; CSPB1; Cachexia; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Division Cycle; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chromatin; Code; Coding System; Complex; Cues; Cytostatic Drugs; Cytostatics; EC 2.3.1.-; EP300; EP300 gene; EXIP; Elements; Gene Expression; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Growth; Histone Acetylase PCAF; IGF-1; IGF-I; IGF-I-SmC; IGF1; INFLM; In Vitro; Inflammation; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Isoforms; JN kinase kinase; JNK; JNK kinase; JNK-activating protein kinase; JNK1; JNK1A2; JNK21B1/2; JNKK; Jun amino-terminal kinase kinase; Knowledge; Ligand Binding Protein; MAP Kinase 8 Gene; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; Malignant Neoplasms; Malignant Tumor; Mediating; Molecular; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Mxi2; MyoD Factor; MyoD Protein; Myocytes; Natural regeneration; Nucleic Acid Regulatory Sequences; P-CAF protein; P/CAF; PCAF; PI-3K/AKT; PI3CG; PI3K/AKT; PI3KGamma; PI3k; PIK3; PIK3CG; PIK3CG gene; PRKM14; PRKM15; PRKM8; Pathway interactions; Pattern; Phosphorylation; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Protein Phosphorylation; Proteins; RNA Expression; Reagent; Regeneration; Regenerative Medicine; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Resistance; Role; SAPK1; SAPK2A; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Somatomedin C; Specificity; Stimulus; Stress; System; System, LOINC Axis 4; Testing; Tissue Growth; Transcription; Transcription, Genetic; base; biological signal transduction; chromatin modification; chromatin remodeling; cultured cell line; gene product; genetic regulatory element; improved; interventional strategy; malignancy; mutant; neoplasm/cancer; neuromuscular disorder therapy; ontogeny; p300; p300 acetyltransferase; p300-CREB-binding protein-associated factor; p300/CBP-Associated Factor; p38; p38 MAPK Gene; p38Alpha; pCAF protein; pathway; programs; regenerate; resistant; response; sarcopenia; social role",Control of muscle gene expression by signaling pathways,,52779,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,5,356270,
7760136,R01,AR,5,,02/01/2010,01/31/2011,PA-05-038,5R01AR053242-06,,NIAMS:268613;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PITTSBURGH,UNITED STATES,SURGERY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"ROTHSTEIN, DAVID M;",1881907;,5R01AR053242,04/26/2006,01/31/2011,"ATGN; Address; Allogenic; Allografting; Animal Model; Animal Models and Related Studies; Antigens; Autologous; B220; Blotting, Western; Bone Marrow Transplant; Bone Marrow Transplantation; CD45; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Infiltration; Characteristics; Chimerism; Cytosolic Protein Tyrosine Phosphastase; Data; Dermatoplasties; Dermatoplasty; Development; Dose; Duchene; Duchenne; Duchenne de Boulogne muscular dystrophy; Duchenne disease; Duchenne dystrophy; Duchenne muscular dystrophy; Duchenne muscular dystrophy (DMD); Duchenne myodystrophy; Duchenne pseudohypertrophic muscular dystrophy; Duchenne syndrome; Duchenne-Griesinger syndrome; Dystrophin; Ellis-van Creveld (EvC) syndrome; Engraftment; Exhibits; Family; Future; GP180; GVHD; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Goals; Graft-Versus-Host Disease; Graft-vs-Host Disease; Grafting, Bone Marrow; Hematopoietic; Histocompatibility; Homologous Wasting Disease; Immune; Immune response; Immune system; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Immunotherapeutic agent; Inbred mdx Mice; Infection; Inflammatory; Integral Membrane Protein; Intervention, Genetic; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Investigators; Isoforms; Kidney; LCA; LY5; Lymphocyte; Lymphocytic; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Transplantation; Mediating; Mice; Mice, Inbred mdx; Modeling; Molecular Biology, Gene Therapy; Monkeys; Mouse, mdx; Murine; Mus; Muscle; Muscle Cells, Embryonic; Muscle Cells, Precursor; Muscle Fibers; Muscle Tissue; Muscular Dystrophy, Duchenne; Muscular Dystrophy, Pseudohypertrophic; Myoblasts; Myotubes; Natural immunosuppression; Organ; PTPRC; PTPRC gene; PTPase; Peripheral; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Physiology; Progenitor Cell Transplantation; Programs (PT); Programs [Publication Type]; Progressive Muscular Dystrophy, Duchenne Type; Protein Isoforms; Protein Tyrosine Phosphatase; Proteins; Protocol; Protocols documentation; Pseudohypertrophic Muscular Dystrophy, Childhood; Radiation, Whole-Body; Regimen; Regulation; Regulatory T-Lymphocyte; Research Personnel; Researchers; Resistance; Rest; Rhabdomyocyte; Role; Runt Disease; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Skin Transplantation; Skin graft; Solid; Specificity; Stem Cell Transplantation; Stem cell transplant; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T200; Therapy, DNA; Thymus-Dependent Lymphocytes; Tissue Compatibility; Tissue Transplantation; Total Body Irradiation; Toxic effect; Toxicities; Transmembrane Protein; Transplantation; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; Western Blotting; Western Blottings; Western Immunoblotting; Whole-Body Irradiation; X-linked dilated cardiomyopathy; X-linked dilated cardiomyopathy (XLCM); X-linked muscular dystrophy; X-linked recessive muscular dystrophy; allogenic skin graft; base; benign X-linked recessive muscular dystrophy; biological signal transduction; body system, allergic/immunologic; childhood pseudohypertrophic muscular dystrophy; classic X-linked recessive muscular dystrophy; conditioning; cytokine; design; designing; experiment; experimental research; experimental study; function improvement; functional improvement; gene product; gene therapy; genetic therapy; grafting, skin; host response; human disease; immunogen; immunogenic; immunogenicity; immunologic preparation; immunoresponse; immunosuppression; immunotherapeutics; insight; irradiation; islet; islet allograft; kidney allograft; lymph cell; malignancy; mild X-linked recessive muscular dystrophy; model organism; muscle strength; neoplasm/cancer; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; organ system, allergic/immunologic; pre-clinical; preclinical; primary outcome; programs; progressive muscular dystrophy of childhood; protein blotting; protein tyrosine phosphate phosphohydrolase; pseudohypertrophic adult muscular dystrophy; pseudohypertrophic muscular paralysis; pseudohypertrophic progressive muscular dystrophy, Duchenne type; renal; renal allograft; research study; resistant; retransplantation; skin allograft; social role; stem; thymus derived lymphocyte; transplant",Immune Tolerence to Transplanted Myoblasts,,53242,ZRG1,Special Emphasis Panel,,6,268613,
7741703,R01,AR,5,,12/01/2009,11/30/2010,,5R01AR053645-05,,NIAMS:313990;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,SAN FRANCISCO,UNITED STATES,ORTHOPEDICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MICLAU, THEODORE ;",2474415;,5R01AR053645,02/01/2006,11/30/2010,"1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-; 21+ years old; Adult; Attention; Biology; Blood Vessels; Body Tissues; Bone; Bone Formation; Bone Regeneration; Bone and Bones; Bone structure of tibia; Bones and Bone Tissue; Cartilage; Cartilagenous Tissue; Cell Differentiation; Cell Differentiation process; Cells; Chondrocytes; Cicatrix; Development; Embryo; Embryonic; Endothelial Cells; Environment; Event; Fracture; Fracture Healing; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Healed; Healing abnormal; Healing delayed; Human, Adult; INFLM; Impaired healing; Impaired tissue repair; Impaired wound healing; Indocin; Indometacin; Indomethacin; Inflammation; Inflammatory; Inflammatory Response; Injury; Life; MMPs; Mammals, Mice; Matrix Metalloproteinases; Mechanics; Mesenchymal; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Mother Cells; Murine; Mus; Mutation; Natural regeneration; Osteoblasts; Osteogenesis; Phase; Physically Disabled; Physically Handicapped; Population; Process; Progenitor Cells; Regeneration; Role; Scars; Series; Site; Skeletal Development; Skeleton; Staging; Stem cells; Techniques; Testing; Tibia; Tissues; Transgenic Mice; Wild Type Mouse; Work; abnormal tissue repair; adult human (21+); angiogenesis; base; bone; bone fracture; bone healing; bone repair; cell type; clinical relevance; clinically relevant; delayed wound healing; experiment; experimental research; experimental study; fetal; genome mutation; healing; injured; intramembranous bone formation; intramembranous ossification; novel; regenerate; repair; repaired; research study; response; skeletal; skeletal tissue; skeletogenesis; social role; soft tissue; stem; stem cell differentiation; tibia; vascular",Biology of stable and non-stable fracture repair,,53645,SBSR,Skeletal Biology Structure and Regeneration Study Section,,5,313990,
7760961,R01,AR,5,,02/01/2010,01/31/2011,PA-07-253,5R01AR054389-04,,NIAMS:322272;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"GAFFEN, SARAH L.;",3108018;,5R01AR054389,04/01/2008,01/31/2013,"Activation, Gene; Adverse effects; Animal Model; Animal Models and Related Studies; Anti-Cytokine Therapy; Applications Grants; Arthritis; Atrophic Arthritis; Attention; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Bears; Binding; Binding (Molecular Function); Binding Site Domain; Biochemical; Blotting, Western; C-EBP Nuclear Protein; C-EBP Proteins; C-terminal; C. albicans; C.albicans; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTLA-8; CTLA8; Cachectin Receptors; Candida; Candida albicans; Causality; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cells, CD4; Chemotherapy-Hormones/Steroids; Chromatography, Exclusion; Chromatography, Gel; Chromatography, Gel Permeation; Colitis; Collagen Arthritis; Collagen-Induced Arthritis; Complex; Crohn's disease; Crohn's disorder; Cytoplasmic Domain; Cytoplasmic Tail; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; DIF; Data; Development; Disease; Disorder; Drug Design; Drugs; EAE; EC 2.7; Edodekin Alfa; Enbrel; Encephalomyelitis, Allergic; Endocrine Gland Secretion; Enteritis, Granulomatous; Etanercept; Etiology; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; External Domain; Extracellular Domain; FRET; Family; Family member; Fibroblasts; Fluorescence Resonance Energy Transfer; Fungus Diseases; Gel Chromatography; Gel Filtration; Gel Filtration Chromatography; Gene Activation; Gene Expression; Goals; Grant Proposals; Grants, Applications; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hormones; Host Defense; Hybrids; IL-1; IL-1 inhibitor, urine; IL-12; IL-17; IL-17A; IL-1ra; IL1; IL1 febrile inhibitor; IL12; IL17; IL17 Protein; IL17A; IL1RN; INFLM; Immune; Immune Precipitation; Immune system; Immunex brand of etanercept; Immunity; Immunoprecipitation; Individual; Inducer Cells; Infection; Infectious Agent; Inflammation; Inflammatory; Inflammatory Arthritis; Integral Membrane Protein; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin I; Interleukin-1; Interleukin-1 Receptor Antagonist; Interleukin-12; Interleukin-17; Interleukins; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Kinases; Knowledge; Ligand Binding; Ligand Binding Domain; Ligands; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Mammals, Mice; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medication; Membrane; Mice; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecular and Cellular Biology; Monilia; Moniliasis, Oral; Murine; Mus; Mycoses; NKSF; Natural Killer Cell Stimulatory Factor; Nature; Opportunistic Infections; Oral; Oral candidiasis; Pathology; Pathway interactions; Patients; Peptide Domain; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Play; Population; Predisposition; Production; Protein Domains; Protein Phosphorylation; Psoriasis; RNA Splicing; RNA, Small Interfering; Receptor Protein; Reporting; Rheumatoid Arthritis; Role; SLE; SLE - Lupus Erythematosus, Systemic; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Structure; Structure-Activity Relationship; Susceptibility; System; System, LOINC Axis 4; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T Helper Factor; T-Cells, Helper-Inducer; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TLR protein; TNF; TNF A; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNF gene; TNFR; TNFSF2; Tail; Tertiary Protein Structure; Th-2 Cell; Th2 Cells; Therapeutic; Therapeutic Hormone; Thrush; Toll-like receptors; Transmembrane Protein; Transphosphorylases; Treatment Side Effects; Tumor Necrosis Factor Gene; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Type 2 Helper Cell; Ursidae; Ursidae Family; Western Blotting; Western Blottings; Western Immunoblotting; Work; Wyeth brand of etanercept; Yeasts; anakinra; arthritic; autoimmune disorder; autoimmune encephalomyelitis; base; biological signal transduction; body system, allergic/immunologic; candida of mouth; chemical structure function; conformation; conformational state; cultured cell line; cytokine; defined contribution; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; disseminated lupus erythematosus; drug/agent; eleocolitis; extracellular; fungal infection; fungus infection; granulomatous enterocolitis; helper T cell; in vivo; infectious organism; inhibitor; inhibitor/antagonist; interleukin 1 inhibitor, urine; interleukin 1 receptor antagonist protein; lymphocyte activating factor; member; membrane structure; model organism; mouse model; mutant; mycotic stomatitis; new approaches; novel; novel approaches; novel strategies; novel strategy; oral candida; oral fungal; organ system, allergic/immunologic; pathogen; pathway; pre-clinical; preclinical; protein blotting; psoriasiform; psoriatic; psoriatiform; public health relevance; receptor; regional enteritis; self recognition (immune); siRNA; side effect; social role; stoichiometry; structure function relationship; systemic lupus erythematosis; therapy adverse effect; thrush (disorder); transcription factor; treatment adverse effect; unspecified interleukin; urine-derived IL1 inhibitor",Structure-Function Relationships in the IL-17 Receptor,,54389,III,Innate Immunity and Inflammation Study Section,,4,322272,
7760638,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR054447-03,,NIAMS:315592;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"KOUSTENI, STAVROULA ;",7756407;,5R01AR054447,04/01/2008,01/31/2013,"21+ years old; Accounting; Adult; Affect; Aging; Anaplastic; Androgenic Agents; Androgenic Compounds; Androgens; Apoptosis; Apoptosis Pathway; Apoptotic; Aquadiol; Attenuated; Biological Preservation; Bone; Bone Density; Bone Formation; Bone Mineral Density; Bone and Bones; Bones and Bone Tissue; Cell Death, Programmed; Cells; Chemosensitization; Chemosensitization/Potentiation; Chemotherapy-Hormones/Steroids; Dimenformon; Diogyn; Diogynets; Endocrine Gland Secretion; Equilibrium; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Experimental Models; Experimental Models, Other; Goals; Gonadal Steroid Hormones; Hormonal; Hormones; Human; Human, Adult; Human, General; In Vitro; Lead; Length of Life; Ligands; Longevity; Mammals, Mice; Mammals, Primates; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mechanical Stimulation; Mediating; Mesenchymal; Mice; Models, Experimental; Molecular; Murine; Mus; Osteoblasts; Osteogenesis; Osteoporosis; Osteoporosis, Post-Menopausal; Osteoporosis, Postmenopausal; Ovocyclin; Ovocylin; PTH (1-84); PTH protein, human; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormones; Pb element; Perimenopausal Bone Loss; Periosteum; Periosteums; Population; Postmenopausal Bone Loss; Postmenopausal Osteoporosis; Potentiation; Preservation, Biologic; Preservation, Biological; Primates; Progynon; Property; Property, LOINC Axis 2; Regulation; Relative; Relative (related person); Research; Rodent; Rodentia; Rodentias; Senescence; Sex Hormones; Sex Steroid Hormones; Site; Skeleton; Surface; Testing; Therapeutic Androgen; Therapeutic Effect; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Intervention; Time; Undifferentiated; Woman; adult human (21+); attenuation; balance; balance function; bone; bone mass; bone strength; gonadal steroids; hPTH(1-84); heavy metal Pb; heavy metal lead; human PTH protein; in vivo; intervention therapy; life span; lifespan; men; men's; novel therapeutic intervention; osteoblast differentiation; parathormone; parathyroid hormone, human; preservation; progenitor; public health relevance; senescent; sex; sex steroid; skeletal; therapeutic target",HORMONAL CONTROL OF PERIOSTEAL EXPANSION,,54447,SBDD,Skeletal Biology Development and Disease Study Section,,3,315592,
7765550,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR054450-04,,NIAMS:353566;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BOSTON,UNITED STATES,DENTISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"BARON, ROLAND E;",1881784;,5R01AR054450,02/01/2007,01/31/2012,"Actins; Adhesions; Amplaxin; Applications Grants; Binding; Binding (Molecular Function); Bisphosphonates; Bone; Bone Resorption; Bone and Bones; Bone necrosis; Bones and Bone Tissue; CTTN; Cell Communication and Signaling; Cell Signaling; Clinical; Complex; Cttn protein; DNM2 Protein; DYNII Dynamin; Data; Dephosphin; Dyn2; DynII Protein; Dynamin; Dynamin 2; Dynamin II; EMS1; EMS1 Protein; EMS1 protein, human; Endocytosis; Event; Exocytosis; Extracellular Matrix, Integrins; Feedback; Freezing; GTP Phosphohydrolases; GTPases; Genetic; Goals; Grant; Grant Proposals; Grants, Applications; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hand; In Vitro; Integrins; Intracellular Communication and Signaling; Investigators; Jaw; Knock-out; Knockout; Laboratories; Link; Mammary Tumor and Squamous Cell Carcinoma-Associated Protein; Molecular Interaction; Osteoclastic Bone Loss; Osteoclasts; Osteonecrosis; Phosphorylation; Play; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Protein-Tyrosine Kinases, src; Proteins; Publishing; Regulation; Research Personnel; Researchers; Role; SRC Substrate Cortactin; SRC8; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Transgenic Organisms; Work; base; biological signal transduction; biphosphonate; bisphosphonate; bone; bone quality; cortactin; diphosphonate; drug discovery; enzyme activity; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; human EMS1 protein; in vivo; mutant; novel; p80/85 SRC Substrate; polymerization; programs; research study; response; seal; skeletal; skeletal disorder; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; therapeutic target; transgenic",From Adhesion to Bone Resorption: The role of Dynamin in Osteoclasts,,54450,SBSR,Skeletal Biology Structure and Regeneration Study Section,,4,353566,
7761732,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR054465-04,,NIAMS:275099;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,ROCHESTER,UNITED STATES,ORTHOPEDICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"CHEN, DI ;",6987665;,5R01AR054465,02/01/2007,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; AML3 transcription factor; Apoptosis; Apoptosis Pathway; BCL1; Binding; Binding (Molecular Function); Body Tissues; Bone Diseases; Bone Formation; Bone Tissue; Bone-Derived Transforming Growth Factor; CBFA-1 protein; CBFA-1 transcription factor; CBFA1 protein; CBFalpha runt domain transcription factor 1; CBFalpha1 protein; CCND1; CCND1 Protein; CCND1 gene; CDK; COS Cells; COS-1; Calcified; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Cycle Proteins; Cell Death, Programmed; Cell Division Cycle Proteins; Cell Signaling; Cell-Cycle Regulatory Proteins; Cells; Chondrocytes; Cyclin D1; Cyclin D1 Gene; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; D11S287E; Data; Defect; Development; Disease; Disorder; E3 Ligase; E3 Ubiquitin Ligase; Epiphyseal Plate; Epiphysial cartilage; G1/S-Specific Cyclin D1; GFAC; Gene Transcription; Genes; Genes, Cyclin D1; Genes, PRAD1; Genes, bcl-1; Genetic Transcription; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Plate; Growth Substances; HTRPY; Hypertrophy; Intracellular Communication and Signaling; Investigators; Macropain; Macroxyproteinase; Mediating; Mesenchymal Differentiation; Milk Growth Factor; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Molecular Target; Multicatalytic Proteinase; N-terminal; NH2-terminal; Nuclear Translocation; Osf2 transcription factor; Osteogenesis; PEBP2alphaA protein; PRAD1; PRAD1 Protein; Pathogenesis; Phosphorylation; Physical condensation; Platelet Transforming Growth Factor; Play; Process; Programs (PT); Programs [Publication Type]; Proliferating; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Phosphorylation; Proteins; Proteosome; Proto-Oncogene Proteins c-bcl-1; RNA Expression; Regulation; Research Personnel; Researchers; Role; Runx2 protein; SEF1 protein; SL3-3 enhancer factor 1; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Staging; TGF B; TGF-beta; TGFbeta; Tissues; Transcription; Transcription, Genetic; Transforming Growth Factor beta; U21B31; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; acute myeloid leukemia 3 protein; base; bcl-1 Genes; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; bone disorder; c-bcl-1 Proteins; cdc Proteins; cdk Proteins; chondrodysplasia; condensation; cyclin D; disease/disorder; gene product; inhibitor; inhibitor/antagonist; insight; multicatalytic endopeptidase complex; novel; osteogenic; prevent; preventing; progenitor; programs; social role; transcription factor; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",The Mechanism through which TGF-Beta Maintains Chondrocytes in Proliferating Stag,,54465,SBSR,Skeletal Biology Structure and Regeneration Study Section,,4,275099,
7759537,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR054816-04,,NIAMS:321233;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"VERGARA, JULIO L.;",1881809;,5R01AR054816,04/11/2007,01/31/2012,"21+ years old; Accounting; Address; Adult; Adynamia Episodica Hereditaria; Affect; Animal Model; Animal Models and Related Studies; Arts; Back; Biological Preservation; Cell Communication and Signaling; Cell Signaling; Characteristics; Chloride; Chloride Channels; Chloride Ion; Chlorides; Cl- element; Control Animal; Coupling; Dependence; Development; Disorder of muscle, unspecified; Dorsum; Dysfunction; Dystrophia Myotonica; Electrodes, Miniaturized; Electrophysiology; Electrophysiology (science); FRET; Fiber; Fluorescence Resonance Energy Transfer; Frequencies (time pattern); Frequency; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Goals; Human; Human, Adult; Human, General; Hybrids; Hyperkalemic periodic paralysis; Individual; Intracellular Communication and Signaling; Investigation; Investigators; Ion Channel; Ion Channels, Chloride; Ionic Channels; Ions; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knowledge; Length; Mammals, Mice; Man (Taxonomy); Man, Modern; Math Models; Measures; Mediating; Membrane; Membrane Channels; Membrane Potentials; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Microelectrodes; Modeling; Molecular; Murine; Mus; Muscle; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Diseases; Mutant Strains Mice; Mutation; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotonia; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Myotonic Periodic Paralysis; Myotubes; Na element; Nature; Neurophysiology / Electrophysiology; Optics; Palsy; Paralysed; Paralysis, Periodic, Hyperkalemic, Familial; Pathogenesis; Pathway interactions; Pattern; Physiologic; Physiological; Physiopathology; Play; Plegia; Preservation, Biologic; Preservation, Biological; Primary Hyperkalemic Periodic Paralysis; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Radial; Records; Regulation; Relative; Relative (related person); Reporting; Research Personnel; Researchers; Resting Potentials; Rhabdomyocyte; Role; Sarcolemma; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Sodium; Sodium Chloride; Sodium chloride (NaCl); Staining method; Stainings; Stains; Steinert Disease; Surface; System; System, LOINC Axis 4; Techniques; Testing; Transgenic Animals; Transmembrane Potentials; Tubular; Tubular formation; V (voltage); Vacuum; adult human (21+); base; biological signal transduction; electrical property; experiment; experimental research; experimental study; flexor digitorum brevis; genome mutation; mathematical model; mathematical modeling; membrane structure; model organism; mouse mutant; muscular disorder; overexpression; paralysis; paralytic; pathophysiology; pathway; preservation; programs; research study; response; salt; social role; voltage; voltage clamp",Role of the Transverse Tubular System in Mammalian Skeletal Muscle Excitability,,54816,ZRG1,Special Emphasis Panel,,4,321233,
7759538,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR054876-03,,NIAMS:333803;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PHILADELPHIA,UNITED STATES,DERMATOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"FERTALA, ANDRZEJ ;UITTO, JOUNI  (contact);",1868087 (contact);2203288;,5R01AR054876,02/15/2008,01/31/2013,"Address; Animal Welfare; Architecture; Asia; Assay; Athymic Nude Mouse; Basement membrane; Bibliography; Bioassay; Biologic Assays; Biological Assay; Bioreactors; Caliber; Cell Culture Techniques; Cells; Characteristics; Collagen; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complementary DNA; Complex; Corium; Country; Cutaneous; Cutis; DNA, Complementary; Dermal; Dermis; Diameter; Disease; Disorder; Ecological impact; Editorial Comment; Editorial Comment (PT); Elasticity; Engineering; Engineering / Architecture; Engineerings; Environment; Environmental Impact; Epidermis; Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa, Dystrophic; Equipment; Ethics Committees, Research; Evaluation; Fibroblasts; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Goals; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention, Genetic; Investigators; Knockout Mice; Laboratories; Literature; Measurement; Measures; Mechanics; Method LOINC Axis 6; Methodology; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Modeling; Molecular; Molecular Biology, Gene Therapy; Molecular Genetic; Molecular Genetics; Mutation; Nature; Nude Mice; Null Mouse; Patients; Principal Investigator; Procollagen; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Public Health; Published Comment; Recombinants; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Simulate; Skin; Skin Substitutes; Structure; Substitutes, Skin; System; System, LOINC Axis 4; Technology; Testing; Therapeutic Agents; Therapy, DNA; Time; Type VII Procollagen; Variant; Variation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; base; cDNA; cell behavior; density; disease/disorder; experiment; experimental research; experimental study; expiration; gene product; gene therapy; genetic therapy; genome mutation; human subject; keratinocyte; mutant; programs; public health medicine (field); research study; response; shear stress; vertebrata",Molecular Genetics of the Cutaneous BMZ in EB,,54876,ACTS,"Arthritis, Connective Tissue and Skin Study Section",,3,333803,
7772259,R01,AR,5,,03/01/2010,02/28/2011,PA-07-070,5R01AR054937-02,,NIAMS:331939;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,HERSHEY,UNITED STATES,ORTHOPEDICS,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"DONAHUE, HENRY J.;",1869722;,5R01AR054937,04/01/2009,02/28/2014,"Actins; Adhesions; Affect; Age; Aging; Allografting; Animal Model; Animal Models and Related Studies; Atomic Force Microscope; Atomic Force Microscopy; Autograft; Autologous Transplantation; Autotransplant; Biocompatible; Biocompatible Materials; Biomaterials; Biotechnology, Genetic Engineering; Blood Coagulation Factor IV; Bone; Bone Formation; Bone Regeneration; Bone Tissue; Bone Transplantation; Bone and Bones; Bones and Bone Tissue; Ca++ element; Calcineurin; Calcium; Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Adhesion; Cellular Matrix; Cellular Proliferation; Characteristics; Coagulation Factor IV; Cytoskeletal System; Cytoskeleton; Defect; Disease; Disorder; ECM; ERK 1; ERK1 Kinase; Environment; Exposure to; Extracellular Matrix; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinase 1; FAK; FAK1; Factor IV; Focal Adhesion Kinase 1; Force Microscopy; Fungi, Filamentous; Genetic Engineering; Goals; Grafting, Bone; Histologic; Histologically; Human; Human Characteristics; Human Nature; Human, General; Hydroxyapatites; Immune; Implant; In Vitro; Injury; Integrins; Intracellular Communication and Signaling; Lead; Lecithinase C; MAP Kinase 3; MAPK3 Mitogen-Activated Protein Kinase; Mammals, Mice; Man (Taxonomy); Man, Modern; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Mice; Microscopy, Atomic Force; Microtubule-Associated Protein-2 Kinase; Mitogen-Activated Protein Kinase 3; Molds; Molecular Biology, Genetic Engineering; Morbidity; Morbidity - disease rate; Murine; Mus; Musculoskeletal; Nano-topography; Nanoscale Science; Nanotechnology; Nanotopography; Operation; Operative Procedures; Operative Surgical Procedures; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Osteogenesis; P44MAPK; PP2B; PSTkinase p44mpk; PTK2; PTK2 Protein Tyrosine Kinase 2; Pathology; Pathway interactions; Pb element; Phenotype; Phospholipase C; Phosphoric acid, calcium salt (2[{..}]3); Ca3(PO4)2; Polymers; Polystyrenes; Polystyrol; Population; Protein Phosphatase-2B; Protein-Serine-Threonine Kinase p44(mpk); Protocol; Protocols documentation; Recombinant DNA Technology; Regulation; Scanning Force Microscopy; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Source; Staging; Surface; Surgical; Surgical Interventions; Surgical Procedure; Therapeutic; Tissue Engineering; Transgenic Animals; Transplantation, Autologous; adult stem cell; aged; biological signal transduction; bone; bone loss; bone repair; calcium phosphate, tribasic; calcium phosphate, tricalcium salt; disease/disorder; electron beam lithography; endogenous substrate pp120; engineered tissue; experiment; experimental research; experimental study; fluid flow; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; insight; intracellular skeleton; lipophosphodiesterase I; model organism; nano meter scale; nano meter sized; nano scale; nano scale Science; nano tech; nano technology; nanometer scale; nanometer sized; nanoscale; nanotech; new approaches; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; osteogenic; p125(FAK); p125FAK; p44 (MAPK); p44 MAPK; pathway; phosphatidylcholine cholinephosphohydrolase; polybromo; pp125(FAK); pp125FAK; public health relevance; research study; response; scaffold; scaffolding; senescent; shear stress; stem cell differentiation; surface coating; surgery; tricalcium phosphate; wasting","Biophysical signals, biomaterial surface characteristics and hMSC differentiation"," Project Narrative As the aged population increases the need for novel therapeutic approaches to musculoskeletal pathology will also increase. Tissue engineering exploiting adult stem cells is one such approach. This project will develop novel musculoskeletal tissue engineering protocols combining nanotechnology, adult stem cells and biophysical forces that will lead to strategies to replace bone loss to disease, injury and aging.",54937,MTE,Musculoskeletal Tissue Engineering Study Section,,2,331939,
7760609,R01,AR,5,,02/01/2010,01/31/2011,,5R01AR055027-19,,NIAMS:353565;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW YORK,UNITED STATES,PHARMACOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"BURDEN, STEVEN ;",1885137;,5R01AR055027,01/01/1990,01/31/2012,"APF-1; ATP-Dependent Proteolysis Factor 1; Aging; Apoptosis; Apoptosis Pathway; Area; Assay; Atrophic; Atrophy; Atrophy, Muscle; Autophagocytosis; Bed rest; Bedrest; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Cell Death, Programmed; Cell Size; Characteristics; Critical Illness; Critically Ill; Defect; Denervation; Disease; Disorder; Disorder of muscle, unspecified; FLR; Failure (biologic function); Future; Gene Expression; Gene Targeting; Genes; HMG-20; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; High Mobility Protein 20; Immobilization; Individual; Investigators; Knowledge; Lead; Learning; Leukemogenesis/Lymphomagenesis; Ligand Binding Protein; Mammals, Mice; Membrane; Mice; Mice, Mutant Strains; Modeling; Molecular Interaction; Murine; Mus; Muscle; Muscle Disease; Muscle Disorders; Muscle Tissue; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Muscular Diseases; Mutant Strains Mice; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; NRVS-SYS; Nervous; Nervous System; Nervous system structure; Neurologic Body System; Neurologic Organ System; Nutritional; Pathway interactions; Pb element; Play; Programs (PT); Programs [Publication Type]; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; RNA, Small Interfering; Regulatory Element; RegulatoryElement; Research Design; Research Personnel; Researchers; Role; Sarcoplasmic Reticulum; Senescence; Skeletal Muscle Tissue; Skeletal muscle structure; Small Interfering RNA; Starvation; Structure; Study Type; Targetings, Gene; Trauma; Ubiquitin; Vacuole; autophagy; base; design; designing; disease/disorder; experiment; experimental research; experimental study; failure; heavy metal Pb; heavy metal lead; immobilization of body part; in vivo; innervation; insight; leukemogenesis; meetings; membrane structure; mouse mutant; muscular disorder; muscular structure; mutant; nerve supply; neural; orthopedic freezing; pathway; prevent; preventing; programs; protein degradation; relating to nervous system; research study; restoration; senescent; siRNA; skeletal; social role; study design; transcription factor; wasting",Runx1 and muscle wasting,,55027,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,19,353565,
7758310,R01,AR,5,,02/01/2010,01/31/2011,PA-02-136,5R01AR055099-26,,NIAMS:278785;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"SCHNEIDER, MARTIN F;",1861663;,5R01AR055099,07/01/1985,01/31/2012,"21+ years old; Acute; Adult; Binding Proteins; Biological Models; Blood Coagulation Factor IV; Ca Release Channel-Ryanodine Receptor; Ca++ element; Calcium; Calcium-Ryanodine Receptor Complex; Chronic; Coagulation Factor IV; Coupling; Dihydropyridine Receptors; Disease; Disorder; Disorder of muscle, unspecified; Event; Factor IV; Fiber; Frog; Human, Adult; Image; L-Type VDCC alpha-1 Subunit; Ligand Binding Protein; Ligands; Mammals, Mice; Membrane; Mice; Model System; Models, Biologic; Molecular; Monitor; Movement; Murine; Mus; Muscle; Muscle Cells, Embryonic; Muscle Cells, Precursor; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle, Skeletal; Muscle, Voluntary; Muscular Diseases; Myoblasts; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotubes; Peptide Domain; Peptides; Physiologic; Physiological; Process; Property; Property, LOINC Axis 2; Protein Domains; Protein Fragment; Proteins; Rana; Rana (genus); Receptors, Ryanodine; Regulation; Rhabdomyocyte; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Sarcomeres; Sarcoplasmic Reticulum; Scanning; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Speed; Speed (motion); Tertiary Protein Structure; V (voltage); adult human (21+); body movement; disease/disorder; gene product; imaging; membrane structure; muscle aging; muscular disorder; repair; repaired; sensor; social role; voltage",Control of Calcium Release in Skeletal Muscle Fibers,,55099,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,26,278785,
7760918,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR055141-03,,NIAMS:369171;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"YAKAR, SHOSHANA ;",8630609;,5R01AR055141,04/15/2008,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Address; Adult; Affect; Afibrinogenemia; Aging; Alkaline Phosphatase; Animal Model; Animal Models and Related Studies; Antibodies; Apoptosis; Apoptosis Pathway; Area; Autocrine Systems; BUdR; Birth; Blood Serum; Body Tissues; Bone; Bone Density; Bone Formation; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bone Mineral Density; Bone and Bones; Bone remodeling; Bones and Bone Tissue; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Cell Death, Programmed; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Development; Endocrine; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Factor I Deficiency; Fibrinogen Deficiency; GHN; Generalized Growth; Genes; Goals; Growth; Growth Hormone; Growth Hormone 1; Growth Hormone Receptor; Growth and Development; Growth and Development function; Health; Hepatic; Hepatic Tissue; Human; Human, Adult; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Image; Impairment; In Situ Nick-End Labeling; In Vitro; Injection of therapeutic agent; Injections; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Liver; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Modeling; Murine; Mus; Organ; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Osteoblasts; Osteoclasts; Osteogenesis; Parturition; Pituitary Growth Hormone; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Puberty; Receptors, Somatotropin; Regulation; Regulatory Pathway; Risk; Role; STH; Senescence; Serum; Skeleton; Somatomedin C; Somatotropin; Somatotropin Receptor; Staining method; Stainings; Stains; Sum; System; System, LOINC Axis 4; TAM; TUNEL; Tamoxifen; Techniques; Thick; Thickness; Time; Tissue Growth; Tissues; Transgenic Mice; Tripcellim; Trypsin; Uridine, 5-bromo-2'-deoxy-; adult animal; adult human (21+); alkaline phosphomonoesterase; autocrine; base; body system, hepatic; bone; bone loss; bone mass; bone remodelling; cell sorting; glycerophosphatase; hGHN; human puberty; imaging; insight; mature animal; model organism; mouse model; ontogeny; organ system, hepatic; osteoprogenitor cell; paracrine; progenitor; recombinase; response; senescent; skeletal; skeletal tissue; social role; somatotropic hormone; terminal nick end labeling",THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1,,55141,SBDD,Skeletal Biology Development and Disease Study Section,,3,369171,
7799787,R01,AR,5,,03/01/2010,02/28/2011,PA-07-070,5R01AR055543-02,,NIAMS:339161;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PHILADELPHIA,UNITED STATES,ORTHOPEDICS,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BIRK, DAVID E;SOSLOWSKY, LOUIS J. (contact);",1864046;1883642 (contact);,5R01AR055543,04/05/2009,02/28/2013,"Age; Aging; Aging Process; Aging-Related Process; Bgn protein; Biochemical; Biomechanics; Body Tissues; Cell-Extracellular Matrix; Data; Development; ECM; Extracellular Matrix; Flexor; Foundations; Generalized Growth; Growth; Healed; Health Care Costs; Health Costs; Healthcare Costs; Injury; Investigation; L-Leucine; Leucine; Leucine, L-Isomer; Mammals, Mice; Measures; Mechanics; Mediating; Mice; Modality; Modeling; Murine; Mus; Natural regeneration; PG-S1; Pain; Painful; Pattern; Property; Property, LOINC Axis 2; Proteins; Proteoglycan; QOL; Quality of life; Regeneration; Regression Analyses; Regression Analysis; Regression Diagnostics; Regulation; Role; Senescence; Sports; Staging; Statistical Regression; Structure; Structure-Activity Relationship; Tendon Injuries; Tendon structure; Tendons; Testing; Tissue Engineering; Tissue Growth; Tissues; Wild Type Mouse; Work; age effect; aged; aging effect; aging population; biglycan; bone proteoglycan I; chemical structure function; cytokine; decorin; design; designing; disability; engineered tissue; gene product; healing; improved; injury response; intervention design; mutant; novel; ontogeny; proteoglycan I; proteoglycan S1; public health relevance; regenerate; repair; repaired; response; response to injury; restoration; senescent; social role; structure function relationship; therapy design; treatment design",Mature & Aging Tendons: Extracellular Matrix Interactions in the Injury Response," Project Narrative: The focus of this application is to elucidate the regulatory role(s) of interactions involving specific extracellular matrix components in the response to tendon injury as well as in their functional alterations with tendon aging. In sports, at work, or due to aging processes, tendon injuries cause significant pain and disability, resulting in enormous healthcare costs, loss of work, and a decrease in the quality of life.",55543,MTE,Musculoskeletal Tissue Engineering Study Section,,2,339161,
7787013,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR056246-02,,NIAMS:357978;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,NEW YORK,UNITED STATES,ORTHOPEDICS,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"LEE, FRANCIS YOUNG-IN;",7067464;,5R01AR056246,04/01/2009,01/31/2013,"ATP-protein phosphotransferase; Affect; B blood cells; B-Cells; B-Lymphocytes; Bacterial Toxins; Biocompatible Materials; Biomaterials; Biomechanics; Bone; Bone Resorption; Bone and Bones; Bones and Bone Tissue; Bp50; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD115 Antigens; CD117 Antigens; CD40; CDW40; CSF-1; CSF-1-R; CSF1; CSF1 gene; CSF1R Gene Product; Calvaria; Cancers; Carcinoma; Cell Communication and Signaling; Cell Signaling; Cells; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Co-culture; Cocultivation; Coculture; Coculture Techniques; Colony Stimulating Factor 1 Receptor; Colony-Stimulating Factor 1; Common Rat Strains; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Data; Dysfunction; EC 2.7.2-; ERK MAP Kinases; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Femur; Functional disorder; Gene Expression; Goals; Hepatobiliary; Human; Human, General; INFLM; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoglobulin Enhancer-Binding Protein; Implant; In Vitro; Inflammation; Inflammatory; Intracellular Communication and Signaling; Knowledge; Ligands; M-CSF; MAP kinase; MAPK; MCSF; MGC31930; MGC9013; Macrophage Activation; Macrophage Colony Stimulating Factor I Receptor; Macrophage Colony-Stimulating Factor; Macrophage Colony-Stimulating Factor Receptor; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor Receptor; Measures; Mediating; Membrane; Mice; Mitogen-Activated Protein Kinases; Modeling; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Natural Immunity; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Organ Culture; Organ Culture Techniques; Osteoblasts; Osteoclastic Bone Loss; Osteoclasts; Osteolysis; Osteolytic; Particulate; Pathology; Pathway interactions; Periodontal Infection; Physiopathology; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; Protein Kinase; Proto-Oncogene Protein c-kit; Proto-Oncogene Protein fms; Rat; Rattus; Receptor Protein; Receptor, CSF-1; Receptors, M-CSF; Regulation; Research Specimen; Rodent; Rodentia; Rodentias; Role; SCF Receptor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Stem Cell Factor Receptor; Surgical sutures; Sutures; TNFRSF5; TNFRSF5 gene; Testing; Tetracycline Antibiotic; Tetracyclines; Therapeutic Effect; Threonine/Tyrosine Protein Kinase; Ti element; Titanium; Toxin; Transcription Factor NF-kB; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transducers; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; UHMWPE; UHMWPE polyethylene; base; biological signal transduction; bone; bone loss; c kit; c-fms Protein; c-kit Protein; c-kit Receptor; calvarial; cell type; clinical investigation; clinical relevance; clinically relevant; cytokine; epithelial carcinoma; experiment; experimental research; experimental study; extracellular signal related kinase; gene induction; glycogen synthase a kinase; hydroxyalkyl protein kinase; in vivo; inhibitor; inhibitor/antagonist; interfacial; kappa B Enhancer Binding Protein; kit Proto-Oncogene Protein; macrophage; malignancy; melanoma; membrane structure; neoplasm/cancer; novel; nuclear factor kappa beta; osteoclastogenesis; p145(c-kit); p145c-kit; p50; particle; pathophysiology; pathway; phosphorylase b kinase kinase; prevent; preventing; programs; public health relevance; receptor; research study; response; septic; social role; trial regimen; trial treatment; ultra-high MW polyethylene; ultra-high molecular weight polyethylene",ERK Signaling in Inflammatory Bone Loss," Program Director/Principal Investigator (Last, First, Middle): LEE, FRANCIS, YOUNG-IN Project Narrative The clinical rationale underlying this study is that we can prevent or treat clinically important inflammatory bone loss by targeting an ERK-mediated inflammatory pathway with the use of specific topical or systemic inhibitors. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page",56246,MTE,Musculoskeletal Tissue Engineering Study Section,,2,357978,
7769895,R01,AR,5,,03/01/2010,02/28/2011,PA-07-279,5R01AR056288-02,,NIAMS:298416;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PHILADELPHIA,UNITED STATES,BIOMEDICAL ENGINEERING,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"WINKELSTEIN, BETH A;",7851343;,5R01AR056288,04/01/2009,02/28/2014,"Affect; American; Arthritis; Articular Capsule; Articulation; Attenuated; BDNF; Behavioral; Biochemical; Biological Models; Biomechanics; Body Tissues; Brain-Derived Neurotrophic Factor; C Fiber; CAPS; Capsula Articularis; Capsules; Causality; Central Nervous System; Cervical; Cervical Injury; Cervical Pain; Cervical spinal cord injury; Cervicalgia; Cervicalgias; Cervicodynia; Cervicodynias; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Cytokine Activation; Cytokines and Inflammatory Response; Data; Development; Dorsal Root Ganglia; Dysfunction; Etiology; Euler-Gaddum Substance P; Event; Facet Joint; Facet joint structure; Fiber; Foundations; Functional disorder; Future; GDNF; GDNF gene; Ganglia, Spinal; Goals; INFLM; Immune response; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Inflammatory Response Pathway; Injury; Joint Capsule; Joints; Link; MGC34632; Maintenance; Maintenances; Mammals, Rats; Measures; Mechanics; Mediating; Medulla Spinalis; Model System; Modeling; Models, Biologic; Modification; Molecular; Motion; NRVS-SYS; Neck; Neck Ache; Neck Injuries; Neck Pain; Neckache; Nerve Cells; Nerve Fibers; Nerve Unit; Nervous System; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurochemistry; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neuropeptides; Nociception; Nociceptors; Outcome; Pain; Painful; Painless; Pathway interactions; Persistent pain; Physiologic; Physiological; Physiopathology; Production; Programs (PT); Programs [Publication Type]; Public Health; Rat; Rattus; Receptor Protein; Regulation; Relative; Relative (related person); Research; Research Proposals; Role; SP(1-11); Science of neurochemistry; Sensory; Simulate; Source; Spinal; Spinal Anesthesia; Spinal Cord; Spinal Ganglia; Substance P; Symptoms; Syndrome; Synovial Capsule; Testing; Therapeutic Intervention; Time; Tissues; Toxin; Whiplash Injuries; Work; Zygapophyseal Joint; arthritic; capsule (pharmacologic); chronic pain; chronic painful condition; cytokine; disability; disease causation; disease etiology; disease/disorder etiology; disorder etiology; dorsal root ganglion; experiment; experimental research; experimental study; host response; immunoresponse; in vivo; in vivo Model; injured; intervention development; intervention therapy; joint injury; macrophage; neurochemistry; neurokinin 1; neuronal; neurotrophic factor; neurotrophin; neutrophin; nociceptive; nociceptive response; novel; pathophysiology; pathway; prevent; preventing; programs; public health medicine (field); public health relevance; receptor; research study; response; social role; spinal block; therapy development; treatment development; whiplash",Nociceptive Mechanisms in Whiplash Injury," Relevance Whiplash is a public health burden, with staggering annual societal and financial consequences. This research proposal will define mechanisms of whiplash injury that produce persistent pain and will identify how sensory fibers in the facet joint contribute to the onset and maintenance of such symptoms. Physiologic correlates of these injuries and symptoms are also characterized to guide future development of preventions and treatments for neck pain from this common class of injuries for vehicle occupants.",56288,SCS,Somatosensory and Chemosensory Systems Study Section,,2,298416,
7774332,R01,AR,5,,02/01/2010,01/31/2011,PA-07-070,5R01AR056959-02,,NIAMS:329967;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,PITTSBURGH,UNITED STATES,PEDIATRICS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"HIRSCH, RAPHAEL ;",1868154;,5R01AR056959,04/01/2009,01/31/2014,"21+ years old; Activin-Binding Protein; Adult; Apoptotic; Architecture; Arthritis; Articulation; Atrophic Arthritis; Birth; Bone; Bone Density; Bone Formation; Bone Mineral Density; Bone and Bones; Bones and Bone Tissue; CAT Scan, X-Ray; CAT scan; CD25; CT X Ray; CT scan; CTLA-8; CTLA8; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Cells; Co-Stimulator; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Computers; Costimulator; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Development; Disease; Disorder; EMI scan; Edodekin Alfa; Embryo Development; Embryogenesis; Embryonic Development; Engineering / Architecture; Epidermal Thymocyte Activating Factor; FSTL1 Gene Product; Follistatin; Follistatin Like Protein 1; Follistatin-Related Protein 1; Gene Transfer; Human; Human, Adult; Human, General; IFN; IL-1; IL-12; IL-17; IL-17A; IL-2; IL1; IL12; IL17; IL17 Protein; IL17A; IL2; IL2 Protein; IL2R; IL2RA; IL2RA gene; INFLM; Inflammation; Inflammatory; Inflammatory Arthritis; Inflammatory Response; Interferons; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin 2; Interleukin 2 Precursor; Interleukin I; Interleukin II; Interleukin-1; Interleukin-12; Interleukin-17; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Joints; Lymphocyte Mitogenic Factor; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mitogenic Factor; Moab, Clinical Treatment; Monoclonal Antibodies; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Osteoblasts; Osteoclasts; Osteocytes; Osteogenesis; Parturition; Phenotype; Physiology; Play; Production; Property; Property, LOINC Axis 2; Proteins; Receptor Protein; Rheumatoid Arthritis; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure; T Helper Factor; T cell growth factor; T-Cell Activation; T-Cell Depletion; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; TCGFR; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Time; Tomodensitometry; Tomography, Xray Computed; Wild Type Mouse; X-Ray Computed Tomography; adult human (21+); arthritic; biological signal transduction; bone; catscan; computed axial tomography; computerized axial tomography; computerized tomography; cytokine; disease/disorder; gene product; joint destruction; lymphocyte activating factor; mineralization; mouse model; novel; protein structure; public health relevance; receptor; response; social role; thymus derived lymphocyte; tomography; tool; transfer of a gene",Characterization of a novel T cell activating protein in arthritis," The proposed studies will characterize the role in arthritis and joint development of a novel mediator of arthritis progression, FSTL-1. Characterization of FSTL-1 will advance understanding of arthritis and may provide new treatment options.",56959,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,2,329967,
7778913,R01,AT,5,,03/01/2010,02/28/2011,,5R01AT003928-04,,NCCAM:437899;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,OAKLAND,UNITED STATES,,09,150829349,US,CA,94612,KAISER FOUNDATION RESEARCH INSTITUTE,"ELDER, CHARLES R;",6063972;,5R01AT003928,09/01/2007,02/28/2011,"21+ years old; Active Follow-up; Acupoints; Acupressure; Acupuncture Points; Adult; Affect; American; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Belief; Blood Pressure, High; Body Weight Changes; Body Weight decreased; Cancers; Cardiovascular Diseases; Care, Managed; Caring; Cessation of life; Characteristics; Chinese; Chinese People; Communities; Complementary and alternative medicine; Conditioning Therapy; Control Groups; Control Locus; Death; Depression; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; ELIG; Educational process of instructing; Eligibility; Eligibility Determination; Epidemic; Funding; Group Meetings; Guidelines; Health; Home; Home environment; Hour; Human, Adult; Hyperlipemia; Hyperlipidemia; Hypertension; Image; Instruction; Intervention; Intervention Strategies; Ischemic Compression; Life Style Modification; MODY; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Managed Care; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medicine; Meetings, Group; Mental Depression; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mind; Mind-Body Intervention; Mind-Body Medicine; Mind-Body Medicine (with OBSSR); Monitor; NCCAM; NIDDM; National Center for Complementary and Alternative Medicine; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Over weight; Overweight; Participant; Patients; Physical activity; Pressure; Pressure- physical agent; Procedures; Protocol Screening; Psyche structure; Psychosocial Stress; Public Health; QOL; Quality of life; Questionnaires; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Risk Factors; Science of Medicine; Self-Help Groups; Stress; Support Groups; T2D; T2DM; Teaching; Techniques; Testing; Trials, Randomized Clinical; Type 2 diabetes; Type II diabetes; United States; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weight Change; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Weight maintenance regimen; Yin; adiposity; adult human (21+); adult onset diabetes; base; behavior intervention; behavioral intervention; body weight gain; body weight increase; body weight loss; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; corpulence; corpulency; corpulentia; cost; effective intervention; experience; follow-up; food craving; hyperpiesia; hyperpiesis; hypertensive disease; imaging; intervention effect; interventional strategy; ketosis resistant diabetes; malignancy; maturity onset diabetes; meetings; mental; mind body approach; mind body medicine skills; mind body method; mind body techniques; mind body therapy; mind body treatments; mind body wellness; neoplasm/cancer; obese; obese people; obese person; obese population; pilot trial; pressure; prevent; preventing; primary outcome; psychosocial; public health medicine (field); randomisation; randomization; randomized trial; randomly assigned; recruit; satisfaction; secondary outcome; self esteem; self help organization; tool; treatment as usual; weight control; weight loss intervention; weight maintenance; wt gain; wt-loss",Randomized Trial of Tapas Acupressure for Weight Loss Maintenance,,3928,ZRG1,Special Emphasis Panel,,4,437899,
7922124,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA017395-36,,NCI:385599;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,PHARMACOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"GROLLMAN, ARTHUR P;",1874658;,5R01CA017395,01/01/1977,01/31/2013,"7,8-dihydro-8-oxoguanosine; 8-hydroxyguanosine; 8-oxo-7,8-dihydroguanosine; 8-oxoG; 8-oxoGuo; 8-oxoguanosine; Abscission; Active Sites; Address; Affect; Amino Acids; Area; Arts; Back; Binding; Binding (Molecular Function); Biochemical; Cancers; Catalysis; Cells; Chronic Disease; Chronic Illness; Cognitive Discrimination; Complement; Complement Proteins; Complex; Computer Simulation; Computerized Models; Crystallographies; Crystallography; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA N-glycosidase; DNA Repair; DNA glycosylase; Data; Deoxyribonucleic Acid; Development; Discrimination; Discrimination (Psychology); Dorsum; Enzyme Kinetics; Enzymes; Event; Excision; Extirpation; Free Energy; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Guanosine, 7,8-dihydro-8-oxo-; In Vitro; Investigation; Investigators; Kinetic; Kinetics; Lesion; Lesion by Stage; Life; Link; MMH Gene; MUTM Gene; Malignant Neoplasms; Malignant Tumor; Mathematical Model Simulation; Mathematical Models and Simulations; Methods; Modeling; Models, Computer; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutate; Mutation; N-Glycosylase/DNA Lyase Gene; Nature; OGG1; OGG1 gene; OGH1 Gene; Organism; Pathway interactions; Pharmacology; Play; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Proteins; Removal; Research; Research Personnel; Researchers; Role; Series; Simulation, Computer based; Site; Sites, Active; Slide; Specificity; Staging; Structure; Surgical Removal; Thermodynamic; Thermodynamics; Unscheduled DNA Synthesis; aminoacid; analog; base; chronic disease/disorder; chronic disorder; computational chemistry; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; design; designing; experiment; experimental research; experimental study; feeding; gene product; genome mutation; in silico; insight; intercalation; interdisciplinary approach; kinked DNA; living system; malignancy; neoplasm/cancer; oxidative DNA damage; pathway; prevent; preventing; programs; protein complex; repair endonuclease; repair enzyme; research study; resection; simulation; social role; structural biology; virtual simulation",Molecular Pharmacology of Oxidative DNA Damage: Structure and Energetics,,17395,CE,Cancer Etiology Study Section,,36,385599,
7749554,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA018137-35,,NCI:323847;,2010,NATIONAL CANCER INSTITUTE,,HERSHEY,UNITED STATES,PHYSIOLOGY,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"KANUGULA, SREENIVAS ;",10312815;,5R01CA018137,12/01/1978,01/31/2012,"AGT; Abbreviations; Active Follow-up; Active Sites; Address; Alkylating Agents; Alkylation; Alkylators; Amino Acid Sequence; Area; Binding; Binding (Molecular Function); Cancer Causing Agents; Cancer Induction; Carcinogens; Carcinogens, Environmental; Cells; Cellular injury; Chimera Protein; Chimeric Proteins; Cysteine; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA repair protein; DNA-6-O-Methylguanine[protein]-L-Cysteine S-Methyltransferase; Defense Mechanisms; Deoxyribonucleic Acid; E coli; EC 2.1.1.63; Environmental Carcinogens; Escherichia coli; Exposure to; Fission Yeast; Fusion Protein; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Grant; Guanine-O(6)-Alkyltransferase; Half-Cystine; Human; Human, General; Individual; Investigation; Investigators; Kinetic; Kinetics; Knowledge; L-Cysteine; L-Tryptophan; Laboratories; Lesion; Levotryptophan; Life; MGMT; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Methylated-DNA Protein-Cysteine Methyltransferase; Methylated-DNA-Protein-Cysteine S-Methyltransferase; Microorganisms, General; Modeling; Molecular Biology, Mutagenesis; Molecular Biology, Protein Sequencing; Molecular Interaction; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Nitrosamines; Nucleotide Excision Repair; O(6)-AGT; O(6)-Alkylguanine-DNA Alkyltransferase; O(6)-MeG-DNA Methyltransferase; O(6)-Methylguanine DNA Transmethylase; O(6)-Methylguanine Methyltransferase; O(6)-Methylguanine-DNA Methyltransferase; O6-Alkylguanine DNA Alkyltransferase; Oncogens; Pathway interactions; Peptide Sequence Determination; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding; Protein Sequencing; Protein Structure, Primary; Proteins; Reaction; Reagent; Research Personnel; Researchers; Risk; Role; S pombe; Schizosaccharomyces pombe; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Specificity; Substrate Specificity; Targeted DNA Modification; Targeted Modification; Techniques; Therapeutic; Toxic effect; Toxicities; Tryptophan; Unscheduled DNA Synthesis; Variant; Variation; Work; Yeast, Fission; adduct; alkyl group; alkylguanine DNA alkyltransferase; alkyltransferase; base; cancer risk; carcinogenesis; cell damage; cell injury; cytotoxic; enhancing factor; experiment; experimental research; experimental study; follow-up; gene product; genome mutation; genotoxicity; improved; in vitro Assay; in vivo; inhibitor; inhibitor/antagonist; methylguanine DNA methyltransferase; microorganism; mutant; nitrosamides; novel; pathway; programs; protein sequence; psychological defense mechanism; repair; repaired; research study; resistance mechanism; resistant mechanism; response; social role; vector",Persistence of Alkylated DNA Carcinogenesis,,18137,ZRG1,Special Emphasis Panel,,35,323847,
7767732,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA019033-34,,NCI:253145;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,CHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SMITH, AMOS B;",1868026;,5R01CA019033,06/30/1976,01/31/2013,"3-hydroxybutanal; 3-hydroxybutyraldehyde; Alkaloids; Anions; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Architecture; Area; Biological; Biological Factors; Cancer Biology; Cancer Drug; Cancer Treatment; Cell Growth Inhibitors; Chemistry; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Communities; Complex; DNA Sequence Rearrangement; Development; Engineering / Architecture; Evaluation; Evolution; Factor, Biologic; Family; Generations; Gleevec; Glivec; Goals; Grant; Growth Inhibitors; Intervention; Intervention Strategies; Laboratories; Lead; Macrolides; Macromolecular Structure; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Marines; Methods; Modeling; Molecular; Molecular Mechanisms of Action; Molecular Probes; Molecular Structure; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Pb element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Polyenes; Productivity; Programs (PT); Programs [Publication Type]; Promoters, Tumor; Protocol; Protocols documentation; Publications; Reaction; Rearrangement; Reporting; Research; Science of Chemistry; Scientific Publication; Series; Structure; Structure-Activity Relationship; Study models; Synthesis Chemistry; Synthetic Chemistry; Time; Tumor Cell; Tumor Promoters; Tumor-Specific Treatment Agents; United States National Institutes of Health; Vascularization; acetaldol; aldol; analog; anticancer agent; anticancer drug; anticancer therapy; antitumor agent; base; cancer therapy; chemical structure function; chemotherapeutic agent; cytotoxic; design; designing; heavy metal Pb; heavy metal lead; innovate; innovation; innovative; interventional strategy; irciniastatin A; marine natural product; member; neoplastic cell; novel; phorboxazole A; pre-clinical; preclinical; programs; public health relevance; scale up; structure function relationship",Anticancer Agents: Structure and Synthesis,,19033,SBCA,Synthetic and Biological Chemistry A Study Section,,34,253145,
7759206,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA029303-29,,NCI:521493;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"TATTERSALL, PETER ;",1865284;,5R01CA029303,01/01/1981,01/31/2012,"Antibodies; Assay; Behavior; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; Capsid; Capsid Proteins; Cell Communication; Cell Communication and Signaling; Cell Culture Techniques; Cell Interaction; Cell Nucleus; Cell Signaling; Cell-to-Cell Interaction; Cells; Coat Proteins; Cryo-electron Microscopy; Cryoelectron Microscopy; DISSEC; Disease; Disorder; Dissection; Effector Cell; Electron Cryomicroscopy; Genes; Genetic; Genome; Goals; Host Factor; Host Factor Protein; Human; Human, General; ITX; Immune Surveillance; Immunologic Surveillance; Immunological Surveillance; Immunologically Directed Therapy; Immunotherapeutic agent; Immunotherapy; Infection; Integration Host Factors; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; LYT3; Label; METBL; MVB; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Mice Minute Virus; Minor; Molecular; Molecular Mimicries; Molecular Mimicry; Monitor; Multivesicular Body; Murine; Mus; Mutagenesis, Site-Directed; NMR Spectroscopy; Nucleus; Parvovirus; Pathogenesis; Penetration; Peptide Domain; Peptides; Picodnavirus; Process; Production; Property; Property, LOINC Axis 2; Protein Domains; Protein Isoforms; Proteins; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specificity; Spectroscopy, NMR; Structural Protein; Structure; Surveillances, Immunologic; Surveillances, Immunological; Targeted DNA Modification; Targeted Modification; Techniques; Tertiary Protein Structure; Testing; Therapeutic; Time; Tissues; Tropism; Tumor Cell; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Viral; Viral Activity; Viral Coat Proteins; Viral Function; Viral Outer Coat Protein; Viral Physiology; Virion; Virus; Virus Particle; Viruses, General; base; biological signal transduction; cell type; coat (nonenveloped virus); combinatorial; cryoEM; cytotoxic; design; designing; disease/disorder; gene product; immune therapy; immunologic preparation; immunotherapeutics; improved; in vivo; mutant; nano machine; nanomachine; neoplastic; neoplastic cell; nuclear magnetic resonance spectroscopy; parvovirus group; polypeptide; recombinant virus; social role; trafficking; tumor; ubiquination; ubiquitin conjugation; vector; virus host interaction",Molecular Basis of Parvoviral Target Cell Specificity,,29303,VIRA,Virology - A Study Section,,29,521493,
7756570,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA032546-35,,NCI:465360;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,BIOCHEMISTRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"BERNHARD, WILLIAM A;",1885046;,5R01CA032546,02/01/1982,01/31/2013,"2-Deoxyribose; Accounting; Achievement; Achievement Attainment; B-DNA; Base Sequence; Benefits and Risks; Binding; Binding (Molecular Function); Binding Proteins; Biological Models; Chemicals; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Complex; D-erythro-Pentose, 2-deoxy-; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Sequence; DNA lesion; DNA, B Form; DNA-Binding Proteins; Deoxyribonucleic Acid; Deoxyribose; Dose; Dose-Rate; EPR spectroscopy; Electromagnetic Radiation, Ionizing; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Experimental Designs; Film; Foundations; Free Radicals; Gas Chromatography; Goals; HPLC; High Pressure Liquid Chromatography; Histones; Hydration; Hydration status; In element; Indium; Ionizing radiation; Ions; Knowledge; LC/MS; Lesion; Ligand Binding Protein; Low Dose Radiation; Mass Spectrum; Mass Spectrum Analysis; Measures; Model System; Modeling; Models, Biologic; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Nucleotide Sequence; Paramagnetic Resonance; Peptides; Photometry/Spectrum Analysis, Mass; Plasmids; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Radiation; Radiation Chemistry; Radiation-Ionizing Total; Radiochemistry; Reaction; Research; Right-Handed DNA; Role; Route; Sampling; Site; Solvents; Spatial Distribution; Spectrometry, Mass; Spectroscopy, ESR; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Tail; Testing; Unscheduled DNA Synthesis; base; conformation; conformational state; design and construction; electron paramagnetic resonance spectroscopy; experiment; experimental research; experimental study; gene product; improved; in vivo; ionization; liquid chromatography mass spectrometry; nucleic acid sequence; oxidation; plasmid DNA; polypeptide; programs; ray (radiation); research study; social role; solid state; sugar; tetralysine; vapor phase chromatography",Solid State Radiation Chemistry of DNA,,32546,RTB,Radiation Therapeutics and Biology Study Section,,35,465360,
7765613,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA034590-27,,NCI:295888;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"RICHMOND, ANN ;",1862172;,5R01CA034590,04/01/1983,01/31/2013,"(1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione; 1-Phosphatidylinositol 3-Kinase; 3-10C; AMCF-I; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Actins; Adaptor Protein; Adaptor Signaling Protein; Affect; Arrestins; Arthritis; BCAR1 Protein; BCAR1 protein, human; Back; Binding; Binding (Molecular Function); Biological; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Breast Cancer Anti-Estrogen Resistance 1 Protein; Breast Cancer Cell; CDC42; CDC42 Homolog; CDw128b; CKRAS protein; CMKAR2; CRK-Associated Substrate; CURL; CXC-R4; CXCL8; CXCR-4; CXCR2; CXCR4; CXCR4 gene; Cancer cell line; Cancers; Cas protein; Ced5, C. Elegans, Homolog of; Cell Communication and Signaling; Cell Division Cycle 42 (GTP Binding Protein, 25kD); Cell Division Cycle 42 Protein; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cells; Cellular Matrix; Cellular Migration; Chemotaxis; Chemotaxis, Leukocyte; Chronic; Clathrin; Clathrin-Coated Vesicles; Compartment of the Uncoupling Receptors and Ligands; Complex; Crk-associated substrate, human; Cytokines, Chemotactic; Cytokinesis; Cytoplasm; Cytoplasmic Division; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; D2S201E; DOCK, 180-kD; DOCK1; DOCK1 protein; DOCK180; Data; Dedicator of Cyto-Kinesis 1; Dephosphin; Development; Dissociation; Dorsum; Downstream of CRK-Binding Protein, 180-kD; Drug Therapy; Dynamin; EC 2.7; Early Endosome; Endocytic Vesicle; Endocytotic Vesicle; Endosomes; Endothelial Cells; Event; Extravasation; FB22; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; G25K Protein; GAP Proteins; GCP-1; GCP1; GTP; GTP Phosphohydrolases; GTP-Binding Protein, 25-kD; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPase-Activating Proteins; GTPases; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HM89; HSY3RR; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Heterophil Granulocyte; Heterotrimeric G Protein Subunit; Homologous Chemotactic Cytokines; Human Breast Cancer Cell; IL-8; IL8; IL8 gene; IL8R2; IL8RB; IL8RB gene; INFLM; IVM; Image; Immune; In Vitro; Inflammation; Intercrines; Intracellular Communication and Signaling; K60; Kinases; L-Serine; LAP3; LCR1; LECT; LESTR; LUCT; LYNAP; Leakage; Leukocyte Chemotaxis; Leukocytes; Leukotaxis; Ligand Binding; Ligands; Link; Lysosomes; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MDNCF; MONAP; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Marrow Neutrophil; Marrow leukocyte; Mediating; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Modeling; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Motility; Motility, Cellular; NAF; NPY3R; NPYR; NPYRL; NPYY3R; Neoplasm Metastasis; Neutrophilic Granulocyte; Neutrophilic Leukocyte; P130 platelet protein, human; P130 protein, human; P130Cas protein, human; PI-3 Kinase; PI-3K; PI3-Kinase; PIP2; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTPA; Pathway interactions; Pharmacotherapy; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositol-4,5-Bisphosphate; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Phosphotyrosyl Phosphatase Activator; Photons; Plasma Membrane; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Protein Binding; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein-Tyrosine Kinases, src; Proteins; PtIns 4,5-P2; PtdIns 3-Kinase; PtdInsP2; Receptor Protein; Receptosomes; Recruitment Activity; Recycling; Resistance; Reticuloendothelial System, Leukocytes; Role; SCYB8; SIS cytokines; Secondary Neoplasm; Secondary Tumor; Sepsis; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Spillage; TSG-1; Testing; Time; Transphosphorylases; Tumor Angiogenesis; Tumor Cell; Tumor Cell Migration; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; VASP; VESCL; Vesicle; White Blood Cells; White Cell; arrestin 2; arthritic; b-ENAP; biological signal transduction; bloodstream infection; breast cancer anti-estrogen resistance 1, human; cancer metastasis; cdc42 GTP-Binding Protein; cdc42 Protein; cell motility; chemoattractant cytokine; chemokine; chemokine receptor; clathrin A; coated pit; d-Numb; gene product; guanosinetriphosphatase; guanosinetriphosphatase activating protein; human BCAR1 protein; imaging; in vivo; insight; intervention design; intracellular skeleton; intravital microscopy; kinase inhibitor; late endosome; malignancy; membrane structure; neoplasm/cancer; neoplastic cell; neutrophil; new therapeutic target; numb protein; p130 Crk-associated substrate protein, human; p130 cas protein; p130CAS; p21 cdc42; pathway; perlecan; plasmalemma; protein protein interaction; public health relevance; receptor; recruit; resistant; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; therapy design; trafficking; treatment design; tumor growth; vasodilator-stimulated phosphoprotein; white blood cell; white blood corpuscle; wortmannin",Chemokine Receptor Studies: Defining the Dynamics of the Chemosynapse,,34590,TPM,Tumor Progression and Metastasis Study Section,,27,295888,
7761296,R01,CA,5,,02/01/2010,12/31/2010,,5R01CA037156-22,,NCI:235523;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,PATHOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"SCHREIBER, HANS ;",6255917;,5R01CA037156,07/01/1984,12/31/2010,"ATGN; Adoptive Transfer; Animals; Antigens; Apoptosis; Apoptosis Pathway; Autoantigens; Autologous Antigens; CD11b; CD8; CD8B; CD8B1; CD8B1 gene; CR3A; Cancer Treatment; Cancers; Cell Death, Programmed; Cells; Cross Presentation; Cytokine Receptors; DIF; Endothelial Cells; FLR; Failure (biologic function); Goals; ITGAM; ITGAM gene; ITX; Immunologically Directed Therapy; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunotherapy; Killings; LYT3; Laboratories; Lead; MAC-1; MAC1A; MO1A; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Mice, Transgenic; Modeling; Murine; Mus; Necrosis; Necrotic; Pathway interactions; Pb element; Reagent; Receptor Protein; Receptors, Cytokine; Research; Resistance; Resolution; Self-Antigens; Solid Neoplasm; Solid Tumor; Stromal Cells; T-Cells; T-Lymphocyte; TNF; TNF A; TNF gene; TNFSF2; Thymus-Dependent Lymphocytes; Transgenic Mice; Transgenic Organisms; Tumor Antigens; Tumor Necrosis Factor Gene; Tumor-Associated Antigen; Tumor-Derived; Variant; Variation; anticancer therapy; cancer cell; cancer progression; cancer therapy; cell type; cytolysin; design; designing; expectation; failure; heavy metal Pb; heavy metal lead; immune therapy; immunogen; in vivo; lymphocyte pore-forming protein; malignancy; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; pathway; perforin; prevent; preventing; receptor; resistant; success; thymus derived lymphocyte; transgenic; tumor; tumor growth; tumor progression; tumor-specific antigen",Immunology of Unique Tumor Specific Antigens,,37156,ZRG1,Special Emphasis Panel,,22,235523,
7798211,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA039504-24,,NCI:289179;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"PENNING, TREVOR M.;",1865672;,5R01CA039504,03/01/1986,12/31/2013,"1,2-benzenediol; 1,2-dihydroxybenzene; 2'-deoxy-7,8-dihydro-8-oxoguanosine; 2-Amino-6-Hydroxypurine; 2-hydroxyphenol; 3,4-Benzopyrene; 3,4-Benzpyrene; 6H-Purin-6-one, 2-amino-1,7-dihydro-; 7-hydro-8-oxodeoxyguanosine; 8-Oxo-2'-Deoxyguanosine; 8-Oxo-dG; 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxo-7,8-dihydrodeoxyguanosine; 8-oxo-7-hydrodeoxyguanosine; 8-oxo-dGuo; 8-oxodG; A549; AHR; AKR1C1; ARNT; ARNT gene; Active Oxygen; Affect; Aromatic Polycyclic Hydrocarbons; Aryl Hydrocarbon Receptor; Assay; Base Excision Repairs; Benzo(a)pyrene; Bioassay; Biologic Assays; Biological Assay; Cancer Causing Agents; Cancer of Lung; Cancers; Carcinogen-DNA Adducts; Carcinogens; Carcinoma, Non-Small-Cell Lung; Catechols; Causality; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Cells; Comet Assay; Common Rat Strains; Consumption; Coupled; DHQU; DIA4; DNA; DNA Adducts; DNA Base Excision Repair; DNA lesion; DT-diaphorase; DTD; Dehydrogenases; Deoxyribonucleic Acid; Diaphorase (NADH/NADPH); Diaphorase-4; Dioxin Receptor, Nuclear Translocator Gene; Environmental Pollutants; Enzymatic Biochemistry; Enzymes; Enzymology; Epidermoid Cell Cancer; Epithelial; Epoxides; Epoxy Compounds; Etiology; Exposure to; Funding; Gel Electrophoresis, Single-Cell; Gene Expression; Gene Expression Profile; Genes; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Genotype; Glycols; Grant; Guanine; H2O2; HIF-1 Beta Gene; HIF-1Beta Gene; HIF-1beta; HIF1-Beta Gene; HIF1B; HIF1B Gene; HIF1Beta; HIF1beta Gene; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypoxia-Inducible Factor 1 Beta Gene; Hypoxia-Inducible Factor 1, Beta Subunit Gene; IARC; In Vitro; Individual; Intermediary Metabolism; International Agency for Research on Cancer; Isoforms; Lead; Lesion; Lung; Lung Adenocarcinoma; METBL; Malignant Cell; Malignant Epidermoid Cell Neoplasm; Malignant Epidermoid Cell Tumor; Malignant Neoplasms; Malignant Squamous Cell Neoplasm; Malignant Squamous Cell Tumor; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Menadione Reductase; Metabolic; Metabolic Activation; Metabolic Processes; Metabolism; Mice; Molecular; Murine; Mus; Mutation; NAD(P)H Dehydrogenase (Quinone) 1; NAD(P)H dehydrogenase (quinone) 1, human; NAD(P)H[{..}]Quinone Oxidoreductase; NADPH[{..}]Quinone Reductase; NMOR1; NMORI; NQO1; NQO1 gene; NQO1 protein; NQO1 protein, human; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Natural regeneration; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Nuclear Translocator; Nucleus; O element; O-D-DG; O2 element; Oncogens; Oral; Oxidation-Reduction; Oxidoreductase; Oxygen; Oxygen Radicals; P53; PAH; Pathway interactions; Pb element; Phase; Phenotype; Phylloquinone Reductase; Play; Polycyclic Hydrocarbons, Aromatic; Polynuclear Aromatic Hydrocarbons; Predisposition; Pro-Oxidants; Production; Protein Isoforms; Pulmonary Cancer; Pulmonary malignant Neoplasm; Pyrocatechols; QR1; Quinone Compound; Quinone Oxidoreductase; Quinone Reductases; Quinones; Rat; Rattus; Reactive Oxygen Species; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Recombinants; Redox; Reductases; Regeneration; Repairs, Base Excision; Reporting; Respiratory System, Lung; Risk Assessment; Role; Smoker; Specificity; Squamous Cell Cancers; Superoxide Anion; Superoxide Radical; Superoxides; Susceptibility; TCDD Receptors; TP53; TP53 gene; TRP53; Testing; Time; Tobacco; Tobacco smoke; Tumor Protein p53 Gene; Variant; Variation; Zeta-Crystallin; adduct; ahr ligand; aryl hydrocarbon receptor ligand; cancer cell; cancer initiation; cigarette smoke; cigarette smoke-induced; cultured cell line; diaphorase 4, human; dioxin receptor, nuclear translocator; disease causation; disease etiology; disease/disorder etiology; disorder etiology; gene expression signature; genome mutation; heavy metal Pb; heavy metal lead; improved; lung cancer; lung carcinogenesis; malignancy; neoplasm/cancer; nonsmall cell lung cancer; o-Dihydroxybenzenes; oral dysplasia; ortho-Dihydroxybenzenes; oxidation reduction reaction; oxidative DNA damage; pathway; polynuclear aromatic hydrocarbon; public health relevance; pulmonary; quinone reductase 1, human; regenerate; repair endonuclease; repair enzyme; response; smoke of cigarettes; social role; stable isotope; tobacco exposure; transcriptome",Aldo-Keto Reductases and PAH Metabolism/Activation, Narrative: Human aldo-keto reductases (AKRs) are tobacco exposure and response genes and are implicated in the initiation of cancer of the airway. AKRs activate tobacco polycyclic aromatic hydrocarbons (PAH) to yield reactive and redox-active PAH o-quinones. This proposal will identify genes that eliminate these quinones or their catechol redox partners and demonstrate that in lung and buccal cancer cells AKRs increase the oxidative mutagenic burden. These studies will inform genotyping and validate genomic studies of cancer of the airway and improve risk assessment prediction.,39504,CE,Cancer Etiology Study Section,,24,289179,
7759117,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA039621-26,,NCI:296871;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"HAMILTON, THOMAS ALAN;",1864797;,5R01CA039621,05/01/1987,01/31/2014,"1H-Purin-6-amine; 3' Untranslated Regions; 3'UTR; 4q Chemokine; Adaptor Protein; Adaptor Signaling Protein; Adenine; Attention; Base Sequence; Behavior; Binding; Binding (Molecular Function); Binding Proteins; Body Tissues; C-X-C Chemokines; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSBP1; CSBP2; CSPB1; CTLA-8; CTLA8; CXC Chemokines; CXCL1; CXCL1 gene; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Chronic Disease; Chronic Illness; Coupled; Coupling; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Decay, mRNA; Development; Disease; Disorder; EC 2.7; EXIP; Elements; Epithelial Cells; Evaluation; Event; Exhibits; Family; Functional RNA; G0-G1 switch regulatory protein 24; GOS24 protein; GRO1; GROA; Gene Expression; Gene Products, RNA; Genes; Grant; Half-Life; Half-Lifes; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Homologous Chemotactic Cytokines; Human; Human, General; IL-1; IL-17; IL-17A; IL1; IL1 Receptors; IL17; IL17 Protein; IL17A; INFLM; IRAK; IRAK1; IRAK1 gene; Immune; Inducer Cells; Inflammation; Inflammatory; Inflammatory Response; Instability, mRNA; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin I; Interleukin-1; Interleukin-1 Receptors; Interleukin-17; Intracellular Communication and Signaling; Kinases; Ligand Binding Protein; Lymphocyte-Stimulating Hormone; MAP Kinase Cascades; MAP Kinase Modules; MAP Kinase Signaling Cascades; MAP-kinase-activated kinase 2; MAPK14; MAPK14 gene; MAPKAP kinase 2; MGSA; MK2 protein, human; Macrophage Cell Factor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Melanoma Growth Stimulatory Activity, Alpha, Gene; Messenger RNA; Mice; Micro RNA; MicroRNAs; Molecular; Molecular Interaction; Murine; Mus; Mxi2; Myeloid Cells; NAP-3; Neoplasms; Neutrophil Infiltration; Neutrophil Recruitment; Non-Coding; Non-Coding RNA; NuP475 protein; Nucleotide Sequence; Outcome; PRKM14; PRKM15; Pathway interactions; Pattern; Phosphorylation; Phosphotransferases; Population; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Prevention; Process; Production; Protein Phosphorylation; Proteins; Publishing; RNA; RNA Binding; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Binding Proteins; Receptors, IL-1; Receptors, Interleukin-1; Recruitment Activity; Regulation; Reporting; Ribonucleic Acid; Role; SAPK2A; SCYB1; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; T Helper Factor; T-Cells, Helper-Inducer; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TIS11 protein; TTP protein; Testing; Tissues; Transphosphorylases; Tumors; Urd; Uridine; Vitamin B4; ZFP36 protein; alpha-Chemokines; biological signal transduction; chemoattractant cytokine; chemokine; chronic disease/disorder; chronic disorder; cytokine; design; designing; disease/disorder; enzyme activity; gene product; helper T cell; lymphocyte activating factor; mRNA; mRNA Decay; mRNA Instability; macrophage; malignancy; miRNA; mitogen-activated protein kinase p38; neoplasia; neoplasm/cancer; neoplastic growth; nucleic acid sequence; p38; p38 MAP Kinase; p38 MAPK; p38 MAPK Gene; p38 Protein Kinase; p38 SAPK; p38Alpha; pathway; pelle; prevent; preventing; protein protein interaction; public health relevance; receptor coupling; recruit; response; social role; tristetraprolin; tumor",Post-transcriptional control of inflammatory gene expression," ProjectNarrative IL-17 is now recognized as an important regulator of inflammatory response. Because inflammation and cancer are believed to be causally related, it is important to understand how this process might be regulated to help prevent the initiation and development of this disease. Regulation of inflammation involves changes in the pattern of gene expression and this can be achieved through many molecular mechanisms. IL-17 appears to modulate the expression of chemokine genes that contribute in several ways to cancer development and spread and uses a mechanism that involves altering the rate at which the chemokine messenger RNA is degraded. This proposal is focused upon understanding the mechanisms through which IL-17 (and other stimuli) control degradation of specific inflammation related messenger RNAs and thereby modulates aspects of inflammatory response.",39621,ZRG1,Special Emphasis Panel,,26,296871,
7755022,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA043054-24,,NCI:414776;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"WANG, JEAN Y.J.;",3129200;,5R01CA043054,08/01/1986,01/31/2013,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; (SP-4-2)-Diamminedichloroplatinum; 14-Hydroxydaunomycin; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; APO-1 Antigen; APO-1 Cell Surface Antigen; ATP[{..}]protein-tyrosine O-phosphotransferase; Adriamycine; Alleles; Allelomorphs; Alternate Splicing; Alternative Splicing; Antibodies; Antigenic Determinants; Apoptosis; Apoptosis Antigen 1; Apoptosis Pathway; Apoptotic; Avian Myelocytomatosis Viral Oncogene Homolog; Binding Determinants; Binding Site Domain; Binding Sites; Biological; C-terminal; CD44; CD44 gene; CD95 Antigens; CD95 molecule; CDDP; CHIP assay; CTX; CYCLO-cell; Cancer Treatment; Cancers; Carloxan; Cell Adhesion; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell Surface Glycoproteins; Cells; Cellular Adhesion; Cellular injury; Cessation of life; ChIP (chromatin immunoprecipitation); Chromatin; Ciclofosfamida; Ciclofosfamide; Cicloxal; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clafen; Claphene; Code; Coding System; Combining Site; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cysplatyna; Cytophosphan; Cytophosphane; Cytoxan; DDP; DNA; DNA Damage; DNA Injury; DNA-Dependent RNA Polymerase II; DOX; Death; Deoxyribonucleic Acid; Development; Dichlorodiammineplatinum; Doxorubicin; Doxorubicina; Drug usage; Drugs; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ES cell; Endoxan; Endoxana; Enduxan; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epitopes; Exclusion; Exons; Experimental Models; Experimental Models, Other; Fetal Liver; Fiber Optics; Flanking Repeat Sequences; Fosfaseron; Future; Gene Targeting; Genes; Genes, p53; Genome; Genome, Human; Genomics; Genotoxins; Genoxal; Genuxal; Goals; HEK3; Human; Human Genome; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Import, Nuclear; Intracellular Communication and Signaling; Isoforms; Killings; Kinases; L-Tyrosine; L-tyrosine, dihydrogen phosphate (ester); Laboratories; Ledoxina; Ligand Binding Domain; Light; MDU3; MYC; MYC gene; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane Glycoproteins; Methods; Mice; Mitoxan; Modeling; Models, Experimental; Mother Cells; Murine; Mus; Mutagens; Mutate; Neosar; Normal Cell; Nuclear; Nuclear Import; Oncogenes, myc; P53; PTK; Pathway interactions; Peyrone's Chloride; Peyrone's Salt; Pgp1; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Phosphotyrosine; Photoradiation; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Procytox; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RNA Polymerase B; RNA Polymerase II; RNA Splicing; RNA Splicing, Alternative; Reactive Site; Receptor Protein; Regulation; Reporting; Research; Role; Sendoxan; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Stem cells; Surface Glycoproteins; Survey Instrument; Surveys; Syklofosfamid; TNFRSF6 Receptor; TP53; TP53 gene; TRP53; TYR; Targetings, Gene; Technology; Terminal Repeat; Terminal Repeat Sequences; Testing; Therapeutic; Transphosphorylases; Tumor Cell; Tumor Necrosis Factor Receptor Superfamily, Member 6; Tumor Protein p53 Gene; Tyrosine; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosine-O-phosphate; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; Zytoxan; anticancer therapy; base; biological signal transduction; cancer cell; cancer progression; cancer therapy; cell damage; cell injury; cell killing; cell type; chemotherapy; chromatin immunoprecipitation; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; drug use; drug/agent; embryonic stem cell; experiment; experimental research; experimental study; fas Antigens; fas Receptors; gene product; genotoxic agent; hydroxyaryl protein kinase; in vivo; malignancy; migration; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; para-Tyrosine; pathway; programs; receptor; research study; response; retroviral-mediated; social role; stem cell of embryonic origin; tumor; tumor progression; tyrosyl protein kinase",Nuclear Function of Abl in DNA Damage Response,,43054,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,24,414776,
7759554,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA044722-20,,NCI:205937;,2010,NATIONAL CANCER INSTITUTE,,NEWARK,UNITED STATES,PATHOLOGY,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"STUDZINSKI, GEORGE P;",1866429;,5R01CA044722,06/01/1987,01/31/2012,"1 alpha,25-Dihydroxycholecalciferol; 1 alpha,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D3; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-; ATP-protein phosphotransferase; Adjuvant; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Sense Oligonucleotides; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Antisense Agent; Antisense Oligonucleotides; Arm; Attention; Blood; Blood (Leukemia); Blood Sample; Blood specimen; CSBP1; CSBP2; CSPB1; Calcitriol; Cancers; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chemosensitization; Chemosensitization/Potentiation; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Complement; Complement Proteins; Data; Development; Differentiating Agents; Differentiation Agents; Differentiation Inducer; Differentiation Therapy; Drugs; EXIP; Early-Stage Clinical Trials; Environment; Enzymes; Event; Exposure to; Extracellular Signal-Regulated Kinase Gene; Figs; Figs - dietary; Food Preservatives; GFAC; Gene Expression; Gene Expression Inhibitor; Generations; Genes; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HL-60 Cells; HL60 Cells; Human; Human, General; Imidazole; Immune Precipitation; Immunoblotting; Immunoprecipitation; In Vitro; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Killings; LEUKCL; Leukemia, Granulocytic; Leukemias, General; Leukemic Cell; Link; MAP Kinase 8 Gene; MAP Kinase Gene; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; MEKs; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Markers, Surrogate; Medication; Methods and Techniques; Methods, Other; Mill Hill-2 Viral Oncogene Homolog; Mitogen-Activated Protein Kinase Gene; Molecular; Monitor; Mxi2; Myelocytic Leukemia; Myelogenous Leukemia; Myeloid Leukemia; NLS Peptide; Nature; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Nuclear; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Oligonucleotides, Antisense; Orphan Disease; Oxidation-Reduction; PRKM14; PRKM15; PRKM8; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phenotype; Physiologic; Physiological; Plants; Plants, General; Plasmids; Potentiation; Programs (PT); Programs [Publication Type]; Protein Kinase; Proteins; Protocols, Treatment; Public Health; RAF-1; RAF1; RAF1 gene; RGM; RT-PCR; RTPCR; Redox; Regimen; Regulation; Reticuloendothelial System, Blood; Reverse Transcriptase Polymerase Chain Reaction; Role; Rosemary; SAPK1; SAPK2A; SB 203580; SB203580; SCHED; SUBGP; Sampling; Schedule; Series; Shunt; Shunt Device; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Subgroup; Surface; Surrogate Markers; Techniques; Testing; Treatment Protocols; Treatment Regimen; Treatment Schedule; Upper arm; VIT D; Vitamin D; Vitamin D Analog; abstracting; analog; anti-oxidant; biological signal transduction; c jun; c-jun Gene; carnosic acid; carnosol; chemotherapy; clinical investigation; combat; cost; cultured cell line; drug/agent; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; inhibitor; inhibitor/antagonist; insight; leukemia; macrophage; malignancy; myeloid granulocytic leukemia; myelosis; neoplasm/cancer; novel; oxidation reduction reaction; p38; p38 MAPK Gene; p38Alpha; pathway; phase 1 study; phase 1 trial; phase I trial; phosphorylase b kinase kinase; polyphenol; programs; protocol, phase I; public health medicine (field); research study; response; reverse transcriptase PCR; rosmarinic acid; salvin; scaffold; scaffolding; shunts; social role; transcription factor; translational study; v-RAF-1 Murine Leukemia Viral Oncogene Homolog 1",Vitamin D Analogs as Adjuvants in Chemotherapy,"Narrative: Public Health Significance: Differentiation therapy, which depends on the activation of  existing cellular programs rather than on toxic drugs to combat malignant tumors, is already effective as the  treatment of some cancers. We propose to develop it as therapy for blood malignancy known as myeloid  leukemia, which although kills approximately 15,000 people in USA every year, is unlikely to receive  attention from commercial support for finding its cure. Thus, myeloid leukemia can be considered an orphan  disease, and merits support from public sources for the development of novel therapy.",44722,CDP,Chemo/Dietary Prevention Study Section,,20,205937,
7846776,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA046677-17,,NCI:236009;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,14,620127915,US,NY,10065,HUNTER COLLEGE,"FOSTER, DAVID A;",1869424;,5R01CA046677,08/25/1989,02/28/2014,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Acid, Phosphatidic; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Breast; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Checkpoint; Cell Cycle Progression; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cola; Ensure; First Gap Phase; Fostering; G1 Phase; G1 period; Gap Phase 1; Genetic Alteration; Genetic Change; Genetic defect; Genus Cola; Human; Human, General; In Vitro; Individual; Intracellular Communication and Signaling; Intracellular Second Messengers; Kidney; Lead; Lecithinase D; Lipids; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Molecular; Molecular Medicine; Morphology; Mutation; Nutritional; Oncogenesis; Organism; PI-3 Kinase; PI-3K; PI3-Kinase; Pathology; Pathway interactions; Pb element; Phosphatidic Acid; Phosphatidylcholine Phosphohydrolase; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phospholipase D; Play; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; PtdIns 3-Kinase; RAFT-1 gene product; Rapamune; Rapamycin; Regulation; Role; Second Messenger Systems; Second Messengers; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Stomach; Stress; Therapeutic; Tissue Survival; Translational Research; Translational Research Enterprise; Translational Science; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Urinary System, Kidney; biological signal transduction; cancer cell; cell growth; expectation; gastric; genome mutation; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; lipophosphodiesterase II; living system; mTOR gene product; mTOR protein; malignancy; mammalian target of rapamycin (mTOR); necrocytosis; neoplasm/cancer; novel; pathway; phosphatidylcholine phosphatidohydrolase; prevent; preventing; programs; public health relevance; renal; response; second messenger; social role; translation research enterprise; tumor; tumorigenesis",Phospholipase D-mTOR Survival Signals in Tumorigenesis," Foster, David A Relevance Statement: Title: Phospholipase D-mTOR survival signals in tumorigenesis The proposed study will evaluate the intracellular mechanisms that regulate phospholipase D (PLD) and mTOR in human cancer cells and the impact of these signals on a proposed ""Cell Growth Checkpoint"" in the G1 phase of the cell cycle that we are proposing must be overcome in virtually all human cancers. The project builds on our previous findings that there is elevated phospholipase D (PLD) activity in many human cancer cells and that suppression of PLD activity in these cells results in apoptotic cell death. Targeting the PLD-mTOR signals in cancer cells represents a very promising strategy for resurrecting the default cell death programs that are arguably the first line of defense against cancer - and is therefore a fertile area for translational research.",46677,MONC,Molecular Oncogenesis Study Section,,17,236009,
7840495,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA047148-23,,NCI:711965;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,CHEMISTRY,08,082359691,US,MA,02138,HARVARD UNIVERSITY,"MYERS, ANDREW G;",1884509;,5R01CA047148,04/01/1988,01/31/2011,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 2 Dimensional Gel Electrophoresis; 2-Naphthalenecarboxamide, N-(13-chloro-2,3,6,7-tetradehydro-10-((2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)oxy)-1a,9-dihydro-20-oxo-23-((2,4,6-trideoxy-4-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-9,5-(epoxy(5,2)pyridinopropanoxyethano)-1); 2-quinolinecarboxylic acid; 21-cyanosaframycin B; 3,6-Imino-1H-2-oxa-11c-azanaphth(1,2,3-cd)azulene-5-carboxylic acid, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-, (2aalpha,3alpha,5alpha,6alpha,6aalpha,11balpha)-(-)-; Affinity; Antiproteases; Applications Grants; Area; Azacyclopropanes; Azacyclopropanes, Saturated; Aziridines; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biological; Biological Factors; Biotin; Cancers; Carcinogen-DNA Adducts; Cell Line; Cell Lines, Strains; CellLine; Chemicals; Complex; Complexes, Macromolecular; Covalent Interaction; Cysteine Endopeptidases; Cysteine Protease; Cysteine Proteinases; D-Glyceraldehyde-3-phosphate[{..}]NADP+ oxidoreductase; DNA; DNA Adducts; Dehydrogenases; Deoxyribonucleic Acid; Development; Dimerization; Dimethyleneimines; Drugs; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Electrophoretic Mobility Shift Assay; Endopeptidase Inhibitors; Enzymes; Ethyleneimines; Ethylenimine Compound; Evaluation; Factor, Biologic; Family; GAPD; Generations; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Glyceraldehydephosphate Dehydrogenase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Grant Proposals; Grants, Applications; Hand; Human; Human, General; Hydroxyl; Hydroxyl Radical; Indoles; Inhibition of Cancer Cell Growth; L-Serine; Label; Laboratories; Lead; Learning; Libraries; Ligand Binding Protein; Link; Macromolecular Complexes; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medication; Membrane; Mercaptans; Mercapto Compounds; Methods and Techniques; Methods, Other; Mobility Shift Assay; Molecular Interaction; Molecular Probes; Molecular Target; Natural Products; Oxides; Oxidoreductase; Pathway interactions; Pb element; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphates; Phosphoglyceraldehyde Dehydrogenase; Physiologic; Physiological; Play; Polystyrenes; Polystyrol; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protease Antagonists; Protease Inhibitor; Protein Dimerization; Proteinase Inhibitors; Proteins; Quinone Compound; Quinones; Radiolabeled; Reaction; Reading; Reagent; Reductases; Research; Research Design; Role; Route; Series; Serine; Site; Solid; Structural Chemistry; Structure; Study Type; Sulfhydryl Compounds; Techniques; Thiol Protease; Thiols; Triosephosphate Dehydrogenase; Vitamin H; Work; adduct; analog; antiproliferative agents; avrainvillamide; base; cancer cell; chromophore; coenzyme R; cultured cell line; design; designing; drug/agent; experiment; experimental research; experimental study; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gel shift assay; gene product; heavy metal Pb; heavy metal lead; improved; in vivo; inhibitor; inhibitor/antagonist; inorganic phosphate; kedarcidin chromophore; knock-down; malignancy; member; membrane structure; neoplasm/cancer; novel; nucleophilic addition; overexpression; pathway; programs; quinaldic acid; quinocarcin; quinocarmycin; radiolabel; radiotracer; reconstitute; reconstitution; research study; saframycin A; salinosporamide A; social role; stephacidin B; study design; sulfhydryl group; tool",Synthesis and Study of Natural and Non-natural Antiproliferative Agents,,47148,SBCA,Synthetic and Biological Chemistry A Study Section,,23,711965,
7758842,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA048115-19,,NCI:351688;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"KAVATHAS, PAULA B.;",1900972;,5R01CA048115,07/01/1988,01/31/2013,"ATP[{..}]protein-tyrosine O-phosphotransferase; Adaptor Protein; Adaptor Signaling Protein; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Affect; Affinity; Agonist; Alternate Splicing; Alternative Splicing; Amino Acids; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; CMV; CTL; Cell Communication and Signaling; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cell-Mediated Lympholytic Cells; CellLine; Cells; Chemicals; Complex; Cytolytic T-Cell; Cytomegalovirus; Cytoplasmic Domain; Cytoplasmic Tail; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Development; E coli; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Escherichia coli; External Domain; Extracellular Domain; FLR; FRET; Failure (biologic function); Fluorescence Resonance Energy Transfer; Funding; Genes; Genes, Class I; Genes, MHC Class I; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Grant; HCMV; HEK3; Human; Human Cell Line; Human Identifications; Human, General; Hybridomas; Identifications, Human; Immunoglobulin Domain; Immunoglobulin-Like Domain; Immunotherapy, Adoptive; In Vitro; Individual; Intracellular Communication and Signaling; Isoforms; Killings; Kinetic; Kinetics; Knock-out; Knockout; LYT3; Label; MHC Class I; MHC Class I Genes; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Melanoma; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measurement; Membrane Proteins; Membrane-Associated Proteins; Memory; Messenger RNA; Mice; Molecular; Molecular Analysis; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutation; NMR Spectroscopy; Outcome; PTK; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Peptides; Phosphorylation; Plasmids; Play; Population Distributions; Position; Positioning Attribute; Production; Protein Isoforms; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger; Receptors, Antigen, T-Cell; Regulation; Role; Salivary Gland Viruses; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Spectroscopy, NMR; Splicing; Surface; Surface Plasmon Resonance; Surface Proteins; System; System, LOINC Axis 4; T-Cell Activation; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cell Receptor Interaction; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocytes, Cytotoxic; T8 Cells; T8 Lymphocytes; TCR Activation; TCR Interaction; Testing; Thymus-Dependent Lymphocytes; Transfection; Tumor Cell; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Variant; Variation; Viral; Work; adoptive cell immunotherapy; aminoacid; base; biological signal transduction; cell killing; cell sorting; cultured cell line; cytokine; cytomegalovirus group; design; designing; dimer; experiment; experimental research; experimental study; failure; gene product; genome mutation; human cytomegalovirus; hydroxyaryl protein kinase; insight; mRNA; melanoma; mutant; neoplastic cell; nuclear magnetic resonance spectroscopy; pMHC; pathogen; protein protein interaction; public health relevance; receptor internalization; research study; response; shRNA; short hairpin RNA; small hairpin RNA; social role; thymus derived lymphocyte; tumor; tyrosyl protein kinase; ubiquination; ubiquitin conjugation","Molecular Analysis of CD8, MHC Class I Interaction",,48115,CMIB,Cellular and Molecular Immunology - B Study Section,,19,351688,
7758319,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA050468-19,,NCI:608652;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"DUPONT, WILLIAM D;",1905957;,5R01CA050468,05/01/1990,01/31/2012,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; ACT2; ALK-5 protein; ALK-5 receptor; ALK5; AT744.1; Act-2; Active Follow-up; Activin A Receptor Type II-Like Kinase 53kDa; Activin Receptor-Like Kinase 5; Affect; Age-Years; Agreement; Alleles; Allelomorphs; Anabolism; Androstenedione Aromatase Inhibitor; Aromatase Inhibitors; Assay; Atypia; Atypical hyperplasia; Benign; Bioassay; Biologic Assays; Biological Assay; Biopsy; Body Tissues; Bone-Derived Transforming Growth Factor; Breast; Breast Cancer Risk Factor; Breast Diseases; Breast Disorder; Breast Fibrocystic Change, Proliferative Type; CCL4; CCL4 gene; CYP1B1; Cancer of Breast; Candidate Disease Gene; Candidate Gene; Catechol Estrogens; Catecholestrogens; Causality; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Respiration; Cell Signaling; Cells; Cellular Proliferation; Cellular Respiration; Clinical; Cohort Studies; Concurrent Studies; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; DNA; DNA Damage; DNA Injury; DNA Molecular Biology; Data; Data Set; Dataset; Deoxyribonucleic Acid; Disease; Disease Frequency Surveys; Disorder; Drugs; Ductal; EDS-4-hydroxylase; Epidemiology; Epidemiology, Molecular; Estrogen Metabolism; Estrogen Synthase Inhibitor; Estrogen Synthetase Inhibitor; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrogens, Catechol; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Etiology; Forecast of outcome; GST1; GSTM1; GSTM1 gene; Generations; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Glutathione S-Transferase M1 Gene; Grant; Histologic; Histologically; Individual; Intracellular Communication and Signaling; Investigation; Investigators; Keoxifene; LAG1; Lead; Length; Lesion; Lesion of breast; Lobular; MIP-1-beta; MIP1B; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mediating; Medication; Metabolic Pathway; Methods; Milk Growth Factor; Molecular; Molecular Biology; Molecular Epidemiology; Molecular Genetic; Molecular Genetics; Nested Case-Control Study; Nuclear; Paraffin Embedding; Pathology; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Platelet Transforming Growth Factor; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Prevention; Principal Component Analyses; Principal Component Analysis; Probability; Production; Prognosis; Proliferative Breast Disease; Proliferative Breast Lesion; Proliferative Fibrocystic Change; Proliferative Type Breast Fibrocystic Change; Quinone Compound; Quinones; Race; Racial Group; Raloxifene; Receptor Protein; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Factors; SCYA4; SKR4; SNP; SNPs; Series; Serine/Threonine-Protein Kinase Receptor R4; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Stocks, Racial; Study Subject; Study, Nested Case-Control; TAM; TGF B; TGF-beta; TGF-beta type I receptor; TGFBR-1; TGFBR1; TGFbeta; Tamoxifen; Testing; Therapeutic Estrogen; Tissues; Transforming Growth Factor Beta Receptor I; Transforming Growth Factor Beta Receptor Type I; Transforming Growth Factor beta; Validation; Woman; [6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone; aerobic metabolism; aerobic respiration; base; benign proliferative breast disease; biological signal transduction; biosynthesis; breast lesion; cancer progression; cancer risk; cohort; cytochrome P-450 CYP1B1; cytochrome P450 CYP1B1; cytochrome P4501B1; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; enzyme pathway; estradiol 17-sulfate 4-hydroxylase; estradiol-4-hydroxylase; estrogen 4-hydroxylase; follow-up; heavy metal Pb; heavy metal lead; high risk; malignant breast neoplasm; mammary disorder; member; neoplasm progression; neoplastic progression; novel marker; outcome forecast; oxidative DNA damage; oxidative metabolism; pathway; polymorphism; protein expression; receptor; tumor progression",Epidemiology of Molecular Risk Factors for Breast Cancer,,50468,EPIC,Epidemiology of Cancer Study Section,,19,608652,
7781412,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA055349-17,,NCI:436088;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"SCHEINBERG, DAVID A;",1892686;,5R01CA055349,09/26/1991,01/31/2014,"Affect; Alpha Particle Radiation; Alpha Particles; Animal Model; Animal Models and Related Studies; Antibodies; Apoptosis; Apoptosis Pathway; Biology; Blood (Leukemia); Body Tissues; Cancers; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cells; Chimeric Toxins; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Dose; Early-Stage Clinical Trials; Environment; Foundations; Gamma Globulin, 7S; Goals; Grant; HL-60; HL60; Human; Human, General; ITX; IgG; Immunoglobulin G; Immunologically Directed Therapy; Immunotherapy; Killings; Kinetic; Kinetics; Leukemias, General; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Normal Cell; Outcome; Outcomes of Therapy; Parents; Patients; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Radiation Biology; Radiation Chemistry; Radiation, Alpha; Radio; Radio Conjugates; Radiobiology; Radiochemistry; Radioconjugate; Randomized; Residual Tumors; Resistance; Structure; Therapeutic; Therapeutic Agents; Therapeutic Effect; Therapeutic Uses; Tissues; Toxin Carriers; Toxin Conjugates; Transducers; Translating; Translatings; Treatment Efficacy; Tumor Cell; Tumors, Residual; Unscheduled DNA Synthesis; Whole Organism; Work; antitumor agent; base; cell killing; clinical investigation; cultured cell line; design; designing; direct application; immune therapy; improved; irradiation; language translation; leukemia; malignancy; model organism; neoplasm/cancer; neoplastic cell; neovasculature; novel; particle; phase 1 study; phase 1 trial; phase I trial; programs; protocol, phase I; public health relevance; randomisation; randomization; randomly assigned; residual disease; resistance mechanism; resistant; resistant mechanism; response; sensor; small molecule; therapeutic efficacy; therapeutically effective; therapy outcome; tumor",Biology of Alpha Particle Immunotherapy," Recently, we described a novel class of radioimmunopharmaceutical, ""a targetable atomic nanogenerator,"" with exceptional potency that has entered human use with anti- leukemia activity already evident at the lowest doses in its initial phase 1 trial. The long- term goals of the project are to develop simple targeting vehicles that kill via alpha particle emission and that make use of our understanding of the tumor's response to alpha particle damage.",55349,CII,Cancer Immunopathology and Immunotherapy Study Section,,17,436088,
7756616,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA055536-19,,NCI:308158;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"HOWE, PHILIP H;",6454018;,5R01CA055536,02/01/1992,01/31/2012,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 3' Untranslated Regions; 3'UTR; APF-1; ATP-Dependent Proteolysis Factor 1; ATRA; Accounting; Address; All-trans retinoic acid; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Bone-Derived Transforming Growth Factor; Breast; Cancers; Carcinoma Cell; Carcinoma of Ovary; Carcinoma of the Pancreas; Cell Growth in Number; Cell Line, Transformed; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Clathrin; Data; Defect; Degradation Pathway; Degradative Pathway; Deletion Mutagenesis; Development; Doctor of Philosophy; Elements; Endocytosis; Endoderm; Epithelial; Eukaryota; Eukaryote; Exocrine Pancreas Carcinoma; GSK-3beta; Genetic; Genital System, Male, Prostate; Genomics; Goals; HMG-20; High Mobility Protein 20; Human Prostate; Human Prostate Gland; In element; Indium; Investigators; Lead; Ligand Binding Protein; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Glands, Human; Mammary gland; Mediating; Mesenchymal; Messenger RNA; Mice; Milk Growth Factor; Mixed Embryonal Carcinoma and Teratoma; Modeling; Molecular; Molecular Interaction; Murine; Mus; Nucleotides; Ovarian; Ovarian Carcinoma; Pancreatic carcinoma; Pb element; Ph.D.; PhD; Phosphorylation; Phosphorylation Site; Platelet Transforming Growth Factor; Programs (PT); Programs [Publication Type]; Proliferating; Prostate; Prostate Gland; Prostatic Gland; Protein Binding; Protein Phosphorylation; Proteins; RNA, Messenger; Regulatory Element; Regulatory Pathway; RegulatoryElement; Research Personnel; Researchers; Retinoic Acid; Role; Signal Pathway; System; System, LOINC Axis 4; TGF B; TGF-beta; TGFbeta; Teratocarcinoma; Trans Vitamin A Acid; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transformed Cell Line; Transforming Growth Factor beta; Translational Regulation; Tretinoin; Tretinoinum; Tumor Suppressor Proteins; UTRs; Ubiquitin; Untranslated Regions; Visceral; Vitamin A Acid; all-trans-Retinoic Acid; all-trans-Vitamin A acid; cell transformation; cross-link; crosslink; eukaryotida; gene product; glycogen synthase kinase 3 beta; heavy metal Pb; heavy metal lead; insight; mRNA; malignancy; mammary; neoplasm/cancer; pancreas carcinoma; programs; protein expression; social role; trans-Retinoic Acid; transdifferentiation; transformed cells; tumor; tumor suppressor",Transforming growth factor beta signaling pathways,,55536,TCB,Tumor Cell Biology Study Section,,19,308158,
7779991,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA055577-17,,NCI:264061;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,PATHOLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"CHANG, KUN-SANG ;",1959394;,5R01CA055577,09/01/1992,02/28/2013,"Acute Promyelocytic Leukemia; Affect; Aneuploid; Aneuploidy; Apoptosis Regulation Pathway; Applications Grants; Base Excision Repairs; Binding; Binding (Molecular Function); Cancer Induction; Cell Aging; Cell Cycle Progression; Cell Function; Cell Process; Cell Senescence; Cell physiology; Cells; Cellular Aging; Cellular Function; Cellular Physiology; Cellular Process; Centrosome; Chimera Protein; Chimeric Proteins; Chromosome Segregation; Chromosomes; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Replication; DNA Synthesis; DNA biosynthesis; Development; EC 2.7; Ensure; Enzymes; Excision Repair; Fusion Protein; Genome Instability; Genome Stability; Genomic Instability; Grant; Grant Proposals; Grants, Applications; Human; Human, General; Incidence; Investigation; Investigators; Kinases; Knowledge; Laboratories; Light; M Phase; M phase (cell cycle); Man (Taxonomy); Man, Modern; Mitosis; Mitosis Stage; Molecular Interaction; Monitor; Movement; Myeloid Leukemia, Acute, M3; NHEJ; Non-Homologous End Joining; Nonhomologous DNA End Joining; Pathogenesis; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Photoradiation; Play; Programs (PT); Programs [Publication Type]; Progranulocytic Leukemia; Proteins; Regulation; Regulation of Apoptosis Pathway; Repair, Excision; Repairs, Base Excision; Reporting; Research Personnel; Researchers; Role; Role of nicotinic acetylcholine receptors in the regulation of apoptosis; Screening procedure; Senescence, Cellular; Senescence, Replicative; Site; Stability, Genomic; Subcellular Process; Telomere Pathway; Telomeres, Telomerase, Cellular Aging, and Immortality; Testing; Translational Regulation; Transphosphorylases; Tumor Suppressor Proteins; Two Hybrid; Unscheduled DNA Synthesis; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; aurora-A kinase; auroraA kinase; base; body movement; carcinogenesis; design; designing; experiment; experimental research; experimental study; gene product; homologous recombination; in vivo; interest; novel; overexpression; premature; prevent; preventing; programs; promyelocytic leukemia; protein B; research study; response; screening; screenings; social role; transcription factor; tumor; tumor suppressor; yeast two hybrid system",A Role for PML in Genome Stability and DNA Damage Response,,55577,CG,Cancer Genetics Study Section,,17,264061,
7758828,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA056533-18,,NCI:423750;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"SCHNEIDER, ROBERT ;",1869311;,5R01CA056533,04/01/1992,01/31/2012,"ATP-protein phosphotransferase; Activation, Gene; Acute; Alferon; B virus infection; Cachectin; Cachectin-Tumor Necrosis Factor; Candidate Disease Gene; Candidate Gene; Capsid; Cell Line; Cell Lines, Strains; Cell-Extracellular Matrix; CellLine; Cells; Cessation of life; Chaperone; Chaperone Gene; Chronic; Chronic Hepatitis; Core Protein; DISSEC; Death; Dissection; Down-Regulation; Down-Regulation (Physiology); Downregulation; ECM; Extracellular Matrix; G-interferon; Gamma interferon; Gene Activation; Gene Expression; Generalized Growth; Genes; Ginterferon; Growth; HBV; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatitis B Virus; Hepatitis Virus, Homologous Serum; Hepatitis, Chronic; Hepatoblastoma; Hepatocyte; Herpes simiae infection; Herpesvirus B infection; Hour; IFN Alpha; IFN-Gamma; IFN-g; IFNG; IFNa; Immune; Immunoglobulin Enhancer-Binding Protein; In Vitro; Infection; Inflammatory; Interferon Alfa-n3; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Interferon-gamma; Killings; Knockout Mice; Lesion; Liver Cells; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Chaperones; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Pathway interactions; Pediatric Embryonal Hepatoma; Pediatric Hepatoblastoma; Phosphorylation; Prevention; Protein Kinase; Protein Phosphorylation; Regulatory Protein; Role; Simian B disease; Simian B disorder; Simian B virus infection; Structure; System; System, LOINC Axis 4; TNF-alpha; TNF-binding protein I, human; TNFR55 protein, human; TNFRSF1A; TNFRSF1A protein, human; TNFalpha receptor; Testing; Time; Tissue Growth; Transcription Factor NF-kB; Tumor Necrosis Factor; Tumor Necrosis Factor Binding Protein 1; Tumor Necrosis Factor Receptor Superfamily, Member 1A; Tumor Necrosis Factor Receptor Type 1; Tumor Necrosis Factor-Alpha Receptor; Tumor Necrosis Factor-alpha; Viral; Virus; Virus Replication; Viruses, General; coat (nonenveloped virus); cultured cell line; cytokine; genetic regulatory protein; glycogen synthase a kinase; human TNFRSF1A protein; hydroxyalkyl protein kinase; kappa B Enhancer Binding Protein; lFN-Gamma; mouse model; nuclear factor kappa beta; ontogeny; pathway; phosphorylase b kinase kinase; prevent; preventing; regulatory gene product; response; social role; tumor necrosis factor alpha receptor; tumor necrosis factor binding protein 1, human; tumor necrosis factor receptor 1 (55kD) protein, human; tumor necrosis factor receptor superfamily, member 1A protein, human; virus multiplication; virus pathogenesis",Viral and Cellular Determinants of Hepatitis B Virus Pathogenesis,,56533,VIRA,Virology - A Study Section,,18,423750,
7787034,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA059655-17,,NCI:311901;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LAIMINS, LAIMONIS A;",1935101;,5R01CA059655,09/30/1993,01/31/2014,"Area; Basal Cell; Cancer of Cervix; Cancer of the Uterine Cervix; Cancers; Cause of Death; Cell-Death Protease; Cells; Cervical Cancer; Cervix Cancer; Cleaved cell; Code; Coding System; DNA; DNA Viruses; Deoxyribonucleic Acid; E1 protein; E1 protein, HPV-16; E1 protein, HPV16; E1 protein, Human papilloma virus 16; E1 protein, Human papillomavirus 16; Episome; Epithelial; Epithelium; FDA approved; Gene Expression; Genes, Viral; Genetic analyses; Genome; Goals; Grant; HPV; HPV Vaccine; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papillomavirus 16 E1 protein; Human papillomavirus Vaccine; ICE-like protease; Infection; Infectious Human Wart Virus; Laboratories; Lesion; Life Cycle; Life Cycle Stages; Link; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of cervix uteri; Mediating; Methods; Methods and Techniques; Methods, Other; Oncogenic; Papilloma Virus, Human; Papilloma Viruses; Papillomavirus; Papillomavirus Infections; Papillomavirus, Human; Play; Proteins; Regulation; Role; Survival Rate; Techniques; Vaccines; Viral; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Proteins; Virion; Virus; Virus Particle; Viruses, General; Woman; Work; caspase; cleaved; cystein protease; cystein proteinase; cysteine endopeptidase; gene product; genetic analysis; life course; malignancy; neoplasm/cancer; papilloma virus Infections; prophylactic; public health relevance; social role; tissue culture; virus protein; wart virus",Regulation of Human Papillomavirus Gene Expression," Cervical cancer is the second leading cause of death by cancer in women worldwide and the overall 5-year survival rate is approximately 50%. In 2006, the FDA approved a prophylactic Human Papillomavirus (HPV) vaccine but this vaccine will not protect women against all the HPV types that cause cervical cancer. In addition, it is ineffective in clearing existing lesions as it only blocks initial infection. This study examines how the productive life cycle of these viruses is regulated through changes in viral gene expression and replication. This is an area of high importance as it can identify new targets for anti-viral treatments.",59655,VIRB,Virology - B Study Section,,17,311901,
7758304,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA061986-15,,NCI:257782;,2010,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PATHOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"FRIDMAN, RAFAEL A.;",1889156;,5R01CA061986,07/06/1995,01/31/2011,"Assay; Authorization; Authorization documentation; Bioassay; Biochemical Process; Biologic Assays; Biological Assay; Body Tissues; Cancerous; Cancers; Cell Line; Cell Lines, Strains; Cell membrane; Cell surface; CellLine; Cities; Complex; Cytoplasmic Membrane; Development; Disclosure; Enzymes; Esteroproteases; Face; Generalized Growth; Growth; Human Resources; In Vitro; Information Disclosure; Instruction; Invaded; Knowledge; Last Name; MMP-14 gene product; MMP-X1; MMP14; MMP14 gene product; MMP14 protein, human; MMPs; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Malignant Neoplasms; Malignant Tumor; Manpower; Matrix Metalloproteinase-14; Matrix Metalloproteinases; Membrane; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Names; Peptidases; Peptide Hydrolases; Performance; Permission; Plasma Membrane; Play; Principal Investigator; Printing; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; R01 Mechanism; R01 Program; RPG; Registries; Regulation; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Role; Surface; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Tissues; Tumor Cell; Tumor Cell Invasion; Tumor Invasion; Universities; base; cancer progression; cultured cell line; facial; hESC; human ES cell; human ESC; human MMP14 protein; human embryonic stem cell; in vivo; malignancy; membrane activity; membrane structure; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; personnel; plasmalemma; programs; social role; tumor; tumor progression; tumor proteolysis; tumor xenograft",Dynamic regulation of MT1-MMP at the tumor cell surface and malignancy,,61986,TPM,Tumor Progression and Metastasis Study Section,,15,257782,
7759529,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA062349-17,,NCI:367775;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"ZBOROWSKI, MACIEJ ;",1863045;,5R01CA062349,02/18/1994,01/31/2011,"American; Applications Grants; Bacillus; Bacillus (bacterium); Binding; Binding (Molecular Function); Biopsy Sample; Biopsy Specimen; Blood Precursor Cell; Blood erythrocyte; Blood leukocyte; Blood normocyte; Body Tissues; Cancer Patient; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Count; Cell Culture Techniques; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Mobility; Cell Number; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Signaling; Cell model; CellLine; Cells; Cellular Mobility; Cellular model; Clinic; Clinical; Collaborations; Collection; Culture Media; Detection; Development; Disease; Disease Progression; Disorder; Early treatment; Electrolytes; Elements; Equipment; Erythrocytes; Erythrocytic; Exhibits; Fe element; Funding; Funding Mechanisms; Grant Proposals; Grants, Applications; Hand; Hematopoietic stem cells; Individual; Institution; Instrumentation, Other; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Iron; Label; Laboratories; Lead; Leukocytes; Life; METBL; Magnetism; Malaria; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Manganese; Marrow erythrocyte; Marrow leukocyte; Measurement; Measures; Metabolic; Metabolic Processes; Metabolism; Methods; Mn element; Modification; Molecular Interaction; Mother Cells; Motion; Multiple Myeloma; Myeloma, Plasma-Cell; NIH; National Institutes of Health; National Institutes of Health (U.S.); Ohio; Paludism; Parasites; Pb element; Performance; Peripheral; Plasmodium Infections; Predisposition; Probability; Progenitor Cells; Progenitor Cells, Hematopoietic; Prokaryotae; Prokaryotic Cells; Reagent; Recovery; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reproduction spores; Research; Research Resources; Resources; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Leukocytes; Sampling; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Solutions; Sorting - Cell Movement; Spores; Stem cells; Susceptibility; Suspension substance; Suspensions; System; System, LOINC Axis 4; T-Cell Depletion; Therapeutic Intervention; Tissues; Tumor Cell; United States National Institutes of Health; Universities; Velocimetries; White Blood Cells; White Cell; Work; application in practice; base; biological signal transduction; blood corpuscles; cancer cell; cell sorting; commercialization; cultured cell line; design; designing; disease/disorder; growth media; heavy metal Pb; heavy metal lead; immunocytochemistry; improved; innovate; innovation; innovative; instrument; instrumentation; intervention therapy; magnetic; magnetic cell separation; magnetic cell separation system; magnetic field; malignancy; molecular marker; myeloma; myelomatosis; neoplasm/cancer; neoplastic cell; oxidation; particle; peripheral blood; physical property; practical application; prokaryote; screening; screenings; sorting; suspension; tissue culture; white blood cell; white blood corpuscle",Magnetophoretic Cell Sorting and Analysis,,62349,ISD,Instrumentation and Systems Development Study Section,,17,367775,
7787454,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA064475-15,,NCI:292410;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"ANDERSON, CAROLYN J;",1884788;,5R01CA064475,07/18/1994,12/31/2012,"1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane Cyclic Peptide Deriv; 64Cu-CB-TE2A; 64Cu-TETA-octreotide; Active Follow-up; Address; Affect; Agonist; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; Area; Assay; Athymic Nude Mouse; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemistry; Biodistribution; Biologic Assays; Biological Assay; Cancers; Cell Death; Cell Death, Programmed; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Nucleus; Cell Surface Receptors; CellLine; Cells; Cellular Tumor Antigen P53; Chelating Agents; Chelators; Chemistry, Biological; Combining Site; Complex; Complexons; Copper; Cu element; Cyclic Somatostatin; Cytoplasm; D-Phenylalanyl-L-cysteinyl-L-phenyl-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide Cyclic (2-7)-Disulfide; Data; Development; Diagnostic; Diagnostic Imaging; Dissociation; EGFR; ERBB Protein; ERBB1; Electrons; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Equilibrium; Excretory function; Funding; Future; Genes, p53; Goals; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; HCT 116 Cells; HCT116; HCT116 Cells; HER1; Image; In Vitro; Intermediary Metabolism; Knowledge; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2-7)-disulfide, (R-(R*,R*))-; Label; Lead; Ligands; Lymphocytes, Null; Lysosomes; METBL; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measures; Mediating; Medical Imaging, Positron Emission Tomography; Metabolic Processes; Metabolism; Mice; Mice, Athymic; Mice, Nude; Molecular Interaction; Murine; Mus; Negative Beta Particle; Negatrons; Normal Tissue; Normal tissue morphology; Nuclear; Nucleus; Nude Mice; Null Cells; Null Lymphocytes; Octreotide; Oncoprotein p53; P53; PET; PET Scan; PET imaging; PETSCAN; PETT; Pathway interactions; Pb element; Phosphoprotein P53; Phosphoprotein pp53; Positron Emission Tomography Scan; Positron-Emission Tomography; Production; Property; Property, LOINC Axis 2; Protein Binding; Protein TP53; Protein p53; Proteins; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Radioactive Isotopes; Radioisotopes; Radiolabeled; Radionuclides; Radiopharmaceutical Compound; Radiopharmaceuticals; Reactive Site; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Cell Surface; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Somatotropin Release Inhibiting Hormone; Reporting; Research; Role; SRIH; SRIH Receptors; SRIH-14; Somatostatin; Somatostatin Receptor; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Targeted Radiotherapy; Therapeutic; Therapeutic Effect; Therapeutic Index; Therapeutic Studies; Therapy Research; Toxic effect; Toxicities; Transforming Growth Factor alpha Receptor; Treatment Efficacy; Tumor Cell; Tumor Cell Line; Tumor Cell Nuclei; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressor Proteins; abstracting; balance; balance function; base; c-erbB-1; c-erbB-1 Protein; cancer imaging; cell killing; chelation; clinical relevance; clinically relevant; copper-binding protein; cultured cell line; dosimetry; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; excretion; experiment; experimental research; experimental study; follow-up; gene product; growth hormone release inhibiting factor; heavy metal Pb; heavy metal lead; imaging; improved; in vivo; malignancy; necrocytosis; neoplasm/cancer; neoplastic cell; p53 Antigen; p53 Tumor Suppressor; pathway; proto-oncogene protein c-erbB-1; public health relevance; radioactive drugs; radiolabel; radiotracer; receptor; receptor binding; research study; social role; somatostatin analog; therapeutic efficacy; therapeutically effective; trafficking; tumor; tumor suppressor",RECEPTOR-TARGETED COPPER RADIOPHARMACEUTICALS FOR CANCER IMAGING AND THERAPY," NARRATIVE ABSTRACT: Copper-64 (T1/2 = 12.7 h; + (17.8%); - (38.4%)) radiopharmaceuticals have made an important impact in the area of positron emission tomography (PET) imaging of cancer. In addition to the PET imaging capabilities of 64Cu, this radionuclide also has been shown to be effective for targeted radiotherapy of cancer. This proposal describes research to further develop 64Cu radiopharmaceuticals for cancer imaging and therapy, as well as investigate mechanisms of copper radionuclide trafficking in cells and their impact on tumor cell killing.",64475,ZRG1,Special Emphasis Panel,,15,292410,
7755050,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA065145-17,,NCI:500505;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"FEINBERG, ANDREW P;",1898178;,5R01CA065145,04/01/1994,01/31/2012,"Address; Affect; Apes; Apoptosis; Apoptosis Pathway; Blood; Body Tissues; Cancer Cause; Cancer Causing Agents; Cancer Etiology; Cancers; Carcinogens; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell model; Cells; Cellular Proliferation; Cellular model; Chemoprevention; Chromosomes; Colon; Colorectal Adenoma; Colorectal Adenomatous Polyp; Colorectal Cancer; Colorectal Neoplasms; DNA Alteration; DNA mutation; Data; Defect; Development; Environmental Exposure; Epidemiology, Family Medical History; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial; Family Medical History; Family history of; Funding; Gastroenterology; Gatekeeping; Gene Alteration; Gene Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic Imprinting; Genetic defect; Genetic mutation; Genome; Genomic Imprinting; Grant; History; Human; Human, General; Hypermethylation; IGF-2; IGF-II; IGF2; IGF2 gene; In Vitro; Individual; Insulin-Like Growth Factor 2; Insulin-Like Growth Factor II; Insulin-Like Somatomedin Peptide II; Intestinal Neoplasia; Intestinal Neoplasms; Intestinal Tumor; Intestines Neoplasms; Intracellular Communication and Signaling; Investigators; Knockout Mice; Large Bowel Adenoma; Large Bowel Adenomatous Polyp; Large Intestine Adenoma; Large Intestine Neoplasm; Large Intestine Tumor; Lesion; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Microfluidic; Microfluidics; Modeling; Mother Cells; Mucosa; Mucosal Tissue; Mucous Membrane; Multiplication-Stimulating Activity; Multiplication-Stimulating Factor; Murine; Mus; Mutation; Nature; Neoplasm of the Large Bowel; Neoplasms; Neoplastic Processes; Nested Case-Control Study; Normal Tissue; Normal tissue morphology; Null Mouse; Oncogene Activation; Oncogenesis; Oncogens; Paper; Parental Imprinting; Pathway interactions; Patients; Pongidae; Predictive Value; Predisposition; Prevention; Probability; Progenitor Cells; Programs (PT); Programs [Publication Type]; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; Receptor Signaling; Recording of previous events; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Risk; Risk Marker; Risk-Taking; Role; Science; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Somatomedin A; Somatomedin MSA; Stem cells; Study, Nested Case-Control; Susceptibility; Systems Biology; Testing; Time; Tissues; Tumor of the Intestines; Tumor of the Large Bowel; Tumors; Tumors, Colorectal; Work; adenoma; animal model development; anticancer research; biological signal transduction; cancer prevention; cancer research; cancer risk; chemical carcinogenesis; cohort; colorectal neoplasia; gatekeeper; genetic determinant; genetic epidemiology; genome mutation; great ape; imprint; in vivo Model; inhibitor; inhibitor/antagonist; intestine growth; malignancy; mouse model; neoplasia; neoplasm/cancer; neoplastic growth; novel; pathway; programs; response; social role; tumor; tumorigenesis",Genomic Imprinting in Cancer,,65145,CG,Cancer Genetics Study Section,,17,500505,
7756597,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA066644-12,,NCI:261056;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,PATHOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"SZOMOLANYI-TSUDA, EVA ;",1972321;,5R01CA066644,05/01/1997,01/31/2012,"Address; Affect; Antibodies, Viral; Antibody Formation; Antibody Production; Antibody Response; Antiviral Agents; Antiviral Drugs; Antivirals; B blood cells; B-Cells; B-Lymphocytes; Biological; Biological Models; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Signaling; Cells; Class Switching; Clinical; Collaborations; DNA Tumor Viruses; Defect; Dependence; Gamma Globulin, 19S; Gamma Globulin, 7S; Generations; Germinal Center; Goals; Human; Human, General; IgG; IgM; Immune; Immune system; Immunity; Immunization; Immunocompetent; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunodeficient Mouse; Immunoglobulin Class Switching; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunologic Receptors; Immunologic Stimulation; Immunological Deficiency Syndromes; Immunological Receptors; Immunological Stimulation; Immunostimulation; Impairment; Intracellular Communication and Signaling; Isotype Switching; Kinetic; Kinetics; Laboratories; Life; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Memory; Memory B Cell; Memory B-Lymphocyte; Methods; Mice; Model System; Modeling; Models, Biologic; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouse Strains; Murine; Mus; Oncogenic Viruses; Pathology; Play; Polyoma; Polyoma Viruses; Polyomavirus; Polyomavirus Infections; Process; Reagent; Receptor Protein; Receptor Signaling; Receptors, Immunologic; Regulation; Reporting; Reticuloendothelial System, Spleen; Role; Scientist; Sensitization, Immunologic; Sensitization, Immunological; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spleen; Structure of germinal center of lymph node; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; T-Cells; T-Lymphocyte; TLR protein; Testing; Thymus-Dependent Lymphocytes; Time; Toll-like receptors; Tumor Viruses; Vaccine Design; Viral Antibodies; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Pathogenesis; Viral Proteins; Viral load measurement; Virus; Virus Diseases; Virus-like particle; Viruses, General; Wild Type Mouse; antibody biosynthesis; antiviral antibody; base; biological signal transduction; body system, allergic/immunologic; cell type; experiment; experimental research; experimental study; hypoimmunity; immune deficiency disorder; immune receptor; immunodeficiency; immunoglobulin biosynthesis; in vivo; interest; novel; organ system, allergic/immunologic; receptor; research study; response; social role; thymus derived lymphocyte; tumor; viral infection; virus infection; virus load; virus protein; viruslike particle",Polyomavirus Infection in Immunodeficient Mice,,66644,VIRB,Virology - B Study Section,,12,261056,
7758804,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA068262-15,,NCI:215140;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WAGNER, GERHARD ;",7784827;,5R01CA068262,05/08/1996,01/31/2011,"5' Untranslated Regions; 5'UTR; Affect; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biological; Biology; Boxing; C-terminal; Cancer cell line; Cap Binding Proteins; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Chemicals; Codon, Initiation; Codon, Initiator; Codon, Start; Complex; DNA Helicases; DNA Unwinding Proteins; DNA unwinding enzyme; Development; Dissociation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elements; Environmental Factor; Environmental Risk Factor; Eukaryota; Eukaryote; Event; Funding; GeneHomolog; Generalized Growth; Genetic Translation; Grant; Growth; Homolog; Homologous Gene; Homologue; Human; Human, General; IRES; In element; Indium; Initiation Factors; Initiator Codon; Internal Ribosome Entry Segment; Internal Ribosome Entry Site; Jurkat Cells; Lead; Leishmania; Leishmania (genus); Length; Ligand Binding Protein; Location; MYD-1 Antigen; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Messenger RNA; Methods; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; N-terminal; NH2-terminal; ORFs; Oncogene Products; Oncogene Proteins; Oncoproteins; Open Reading Frames; Parasites; Pb element; Peptide Biosynthesis, Ribosomal; Peptide Initiation Factors; Phase; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Coding Region; Protein Conformation; Protein Synthesis, Ribosomal; Proteins; RFP; RNA Cap-Binding Proteins; RNA Helicase; RNA, Messenger; Recruitment Activity; Regulation; Regulatory Protein; Reporting; Request for Proposals; Research; Ribosome Entry Site; Ribosomes; Role; SHPS-1 protein; SIRP-ALPHA-1; SIRPalpha1; Scanning; Site; Structure; System; System, LOINC Axis 4; Tissue Growth; Translation Initiation; Translation Initiation Factor; Translational Initiation Factor; Translations; UTRs; Untranslated Regions; Variant; Variation; Work; Yeasts; analog; antitumor drug; cell transformation; conformation; conformational state; design; designing; eIF5B; environmental risk; eukaryotic initiation factor-5B; eukaryotida; experiment; experimental research; experimental study; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; helicase; inhibitor; inhibitor/antagonist; interest; mRNA; mRNA Cap Binding Proteins; mRNA Leader Sequences; mRNA Translation; meetings; ontogeny; particle; peptide initiation factor eIF-5B; programs; protein structure; protein synthesis; recruit; regulatory gene product; research study; signal-regulatory protein; small molecule; social role; transformed cells; tumor",Mechanisms of Eukaryotic Translation Initiation,,68262,MSFC,Macromolecular Structure and Function C Study Section,,15,215140,
7752835,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA069457-14,,NCI:272145;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BEAUCHAMP, ROBERT D.;",1902873;,5R01CA069457,06/15/1995,01/31/2012,"Area; Behavior; Benign; Biological; Bone-Derived Transforming Growth Factor; CLDN1; Cancer Patient; Cancer Treatment; Carcinoma; Cell Communication and Signaling; Cell Signaling; Cells; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Colorectal Cancer; Common Smad; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Expression Profiling; Expression Signature; Gene Expression; HER1; Human; Human, General; Intestinal; Intestines; Intracellular Communication and Signaling; Lead; Ligands; Link; MADH4 Protein; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Milk Growth Factor; Molecular Fingerprinting; Molecular Profiling; Molecular Target; Neoplasm Metastasis; Occluding Junctions; Oncogene Products; Oncogene Proteins; Oncoproteins; Outcome; Pattern; Pb element; Phenotype; Platelet Transforming Growth Factor; Prevention; Primary Neoplasm; Primary Tumor; Process; Production; Proteins; RNA, Messenger; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Role; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Smad4 Protein; Staging; TGF B; TGF-beta; TGFbeta; Testing; Therapeutic Intervention; Tight Junctions; Transforming Growth Factor alpha Receptor; Transforming Growth Factor beta; Tumor Cell; Tumor Cell Migration; Tumor Suppressor Proteins; Zonula Occludens; anticancer therapy; base; biological signal transduction; biomarker; bowel; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer metastasis; cancer progression; cancer therapy; claudin-1; claudin-1 protein; clinical relevance; clinically relevant; epithelial carcinoma; epithelial to mesenchymal transition; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gastrointestinal; gene product; heavy metal Pb; heavy metal lead; improved; insight; intervention therapy; mRNA; malignant phenotype; molecuar profile; molecular signature; neoplasm progression; neoplastic cell; neoplastic progression; novel; proto-oncogene protein c-erbB-1; research study; response; restoration; social role; tumor; tumor progression; tumor suppressor; tumorigenic",EMT regulation in gastrointestinal epithelial cells,,69457,ZRG1,Special Emphasis Panel,,14,272145,
7755374,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA070723-14,,NCI:293829;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SUGDEN, WILLIAM M.;",1888497;,5R01CA070723,08/15/1996,01/31/2012,"Antigens, Nuclear; Applied Genetics; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Biopsy; Burkitt Herpesvirus; Burkitt Lymphoma; Burkitt Lymphoma Virus; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Genes; Cancer-Promoting Gene; Carcinoma; Carcinoma of Nasopharynx; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell Survival; Cell Viability; Cells; Complement; Complement Proteins; Complex; Dependence; Development; E-B Virus; EB virus; EBV; EBV Infections; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus Infections; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genes, Viral; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic analyses; Genetic defect; Germinoblastoma; Grant; HHV-4; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Human; Human Herpes Virus 4 Infections; Human Herpesvirus 4; Human Herpesvirus 4 Infections; Human, General; Individual; Infection; Infectious Mononucleosis Virus; Intracellular Communication and Signaling; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lymphomagenesis; Lytic Cycle; Lytic Infection; Lytic Phase; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Membrane Proteins; Membrane-Associated Proteins; Micro RNA; MicroRNAs; Molecular Interaction; Mutation; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; Nuclear Antigens; Oncogenes; Oncogenic; Oncogenic Viruses; Pathway interactions; Phenotype; RNA Expression; Regulation; Reticulolymphosarcoma; Retroviral Vector; Retrovirus Vector; Role; Sarcoma, Germinoblastic; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Surface Proteins; Targetings, Gene; Testing; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transforming Genes; Tumor Viruses; Viral; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Genome; Viral Proteins; biological signal transduction; cellular targeting; epithelial carcinoma; genetic analysis; genome mutation; human herpesvirus 4 group; infected B cell; infected B lymphocyte; miRNA; mutant; pathway; social role; tumor; virus protein",Genetic Analysis of EBV's Immortalizing Genes,,70723,ZRG1,Special Emphasis Panel,,14,293829,
7761279,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA070940-14,,NCI:334005;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,PHARMACOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"PENDERGAST, ANN MARIE ;",1902918;,5R01CA070940,05/15/1996,02/28/2011,"ATP[{..}]protein-tyrosine O-phosphotransferase; Actins; Adaptor Protein; Adaptor Signaling Protein; Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Anchoring Junction; Binding Proteins; Blood capillaries; Body Tissues; Cadherins; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Junctions; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Survival; Cell Viability; Cell surface; Cell-Cell Adhesion; Cells; Cellular Matrix; Cellular Migration; Cellular Oncogene; Complex; Cytoskeletal System; Cytoskeleton; Defect; Development; Drosophila; Drosophila genus; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endothelial Cells; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial; Family; Flies; Fruit Fly, Drosophila; Generalized Growth; Genetic; Goals; Growth; HEK3; HGF/SF; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; In Vitro; Intercellular Junctions; Intracellular Communication and Signaling; Kinases; Knowledge; L-Tyrosine; Ligand Binding Protein; Link; Liver Cell Adhesion Molecules; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; Malignant Cell; Mammalian Cell; Mammals, Mice; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Molecular; Morphogenesis; Motility; Motility, Cellular; Murine; Mus; Neoplasm Metastasis; PTK; Pathway interactions; Phosphorylation; Phosphotransferases; Play; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proto-Oncogenes; Receptor Protein; Regulation; Regulatory Protein; Research; Role; Scatter Factor; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; TYR; Testing; Tissue Growth; Tissues; Transphosphorylases; Tube; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tyrosine; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vascular Permeabilities; angiogenesis; base; biological signal transduction; c-ONC; cancer cell; cancer metastasis; cancer progression; capillary; cell motility; driving force; fly; fruit fly; gain of function; gene product; genetic regulatory protein; hydroxyaryl protein kinase; in vivo; insight; intracellular skeleton; liver cell adhesion molecule; loss of function; meetings; neoplasm progression; neoplastic progression; novel; ontogeny; para-Tyrosine; pathway; polymerization; protein complex; protooncogene; receptor; regulatory gene product; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; social role; tumor; tumor progression; tyrosyl protein kinase",Molecular Basis of Signaling by the cAbL Proto-Oncogene,,70940,TME,Tumor Microenvironment Study Section,,14,334005,
7755442,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA072669-14,,NCI:298185;,2010,NATIONAL CANCER INSTITUTE,,MINNEAPOLIS,UNITED STATES,PEDIATRICS,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"BLAZAR, BRUCE R.;",1880476;,5R01CA072669,04/01/1997,01/31/2012,"AML - Acute Myeloid Leukemia; Address; Affect; Allo BMT; Allogeneic BMT; Allogeneic Bone Marrow Transplantation; Animals; Antigens, LD; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Arts; Biological; CTL; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Treatment; Cancers; Cell Death; Cell Death, Programmed; Cell Locomotion; Cell Migration; Cell Movement; Cell-Mediated Lympholytic Cells; Cells; Cellular Migration; Cessation of life; Coupled; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Death; Defect; Dioxygenases; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Environment; Enzymes; Extremities; Gamma interferon; Generations; Goals; Health Benefit; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic Cancer; Hematopoietic Cell Tumor; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Home; Home environment; Homing; IFN-Gamma; IFN-g; IFNG; ITX; Imaging Procedures; Imaging Techniques; Immune; Immune system; Immunologically Directed Therapy; Immunotherapy; Infectious Diseases / Treatment, General; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Kinetic; Kinetics; Knock-out; Knockout; L-Tryptophan; Leukemia, Myelocytic, Acute; Levotryptophan; Life; Ligands; Limb structure; Limbs; Location; Lymphocyte; Lymphocyte Function; Lymphocyte antigen; Lymphocytic; Malignant Hematologic Neoplasm; Malignant Hematopoietic Neoplasm; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Memory; Mice; Modeling; Motility; Motility, Cellular; Murine; Mus; Myeloblastic Leukemia, Acute; Myelogenous Leukemia, Acute; Non-Trunk; Patients; Phase; Process; Programs (PT); Programs [Publication Type]; Public Health; Regulation; Regulatory T-Lymphocyte; Residual Tumors; Role; Site; Solid Neoplasm; Solid Tumor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Technics, Imaging; Technology; Testing; Thymus-Dependent Lymphocytes; Transgenic Organisms; Treatment of Infectious Diseases; Tryptophan; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumors, Residual; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; anticancer therapy; base; blood cancer; body system, allergic/immunologic; cancer therapy; cell motility; clinical relevance; clinically relevant; cytotoxic; exhaustion; immune therapy; in vivo; indoleamine; infectious disease treatment; insight; lFN-Gamma; lymph cell; lymphocyte differentiation antigen; malignancy; migration; necrocytosis; neoplasm/cancer; novel; organ system, allergic/immunologic; programs; public health medicine (field); residual disease; response; social role; thymus derived lymphocyte; transgenic; tumor; tumor necrosis factor (unspecified)",Cytotoxic-T-Lymphocyte (CTL) Therapy of AML,,72669,ZRG1,Special Emphasis Panel,,14,298185,
7750589,R01,CA,5,,02/01/2010,01/31/2011,PA-07-173,5R01CA073507-13,,NCI:499500;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LONGNECKER, RICHARD M;",1944434;,5R01CA073507,02/01/1997,01/31/2013,"AIDS; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Youth; African; Apoptosis; Apoptosis Pathway; B blood cells; B-Cells; B-Lymphocytes; Biological Models; Birth; Bone Marrow; Burkitt Herpesvirus; Burkitt Lymphoma Virus; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Bypass; Cancers; Carcinoma of Nasopharynx; Cell Culture Techniques; Cell Death, Programmed; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cell/Tissue, Immunohistochemistry; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Clinical, Transplantation, Organ; Death; Development; Disease; Disorder; E-B Virus; EB virus; EBV; EBV latency; EBV-Related Malignancy; EBV-associated disease; EBV-associated malignancy; Embryo; Embryonic; Episome; Epithelial Cells; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus associated disease; Epstein-Barr Virus associated malignancy; Epstein-Barr Virus latency; Epstein-Barr Virus-Related Malignancy; Epstein-Barr Virus-Related Malignant Neoplasm; Family; Generalized Growth; Generations; Genetic Alteration; Genetic Change; Genetic defect; Germinal Center; Germinoblastoma; Glandular Fever; Goals; Grafting Procedure; Growth; HHV-4; HIV/AIDS; HIV/AIDS problem; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Histocytochemistry; Human; Human Herpesvirus 4; Human, General; IHC; IL-7; IL7 Protein; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; Immunologic Diseases; Immunological Diseases; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; In Vitro; Infectious Mononucleosis; Infectious Mononucleosis Virus; Integral Membrane Protein; Interleukin 7 Precursor; Interleukin-7; Intrinsic Membrane Protein; Investigation; Knock-out; Knockout; Knockout Mice; LMP1; Latent virus infection phase; Lymph node proper; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lymphopoietin-1; Lymphoproliferative Disorders; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Model System; Modeling; Models, Biologic; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mutation; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; Natural immunosuppression; Nuclear Protein; Nuclear Proteins; Null Mouse; Oncogenesis; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Partner in relationship; Parturition; Pathology; Patients; Phenotype; Protein-Tyrosine Kinases, src; Proteins; Research; Research Design; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Spleen; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Spleen; Structure of germinal center of lymph node; Study Type; Subcellular Process; System; System, LOINC Axis 4; Techniques; Testing; Tissue Growth; Transgenes; Transgenic Mice; Transgenic Model; Transgenic Organisms; Transmembrane Protein; Transplantation Surgery; Tumor Cell; Viral; Virus; Viruses, General; base; continuous cell line; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; histochemistry; histochemistry/cytochemistry; human herpesvirus 4 group; immunosuppression; in vivo; in vivo Model; infected B cell; infected B lymphocyte; insight; interest; juvenile; juvenile human; latent infection; latent virus infection; lymph gland; lymph nodes; lymphoblastoid cell line; lymphocyte proliferation; lymphoproliferative disease; lyn protein p53; lyn protein-tyrosine kinase; lyn(53) protein; lyn(p56)protein; malignancy; mate; membrane raft resident protein Lyn; mononucleosis; mouse model; mutant; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; organ allograft; organ graft; organ xenograft; p53-p56 lyn; p56lyn protein; pp59(Lyn); prevent; preventing; protein-tyrosine kinase p53(lyn); protein-tyrosine kinase p56(lyn); research study; shRNA; short hairpin RNA; small hairpin RNA; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; study design; transgenic; tumor; tumorigenesis",In Vivo Model of Epstein-Barr Virus Latency,,73507,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,13,499500,
7765610,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA074177-13,,NCI:324865;,2010,NATIONAL CANCER INSTITUTE,,INDIANAPOLIS,UNITED STATES,PEDIATRICS,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"CLAPP, DAVID W.;",1966279;,5R01CA074177,04/01/1997,02/28/2013,"Affect; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Arts; Basophilic Histiocyte; Basophils, Tissue; Biochemical; Biochemical Pathway; Bone Marrow Transplant; Bone Marrow Transplantation; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Complex; Cutaneous; Data; Development; Elephantiasis Neuromatosis; Emerogenes; Endothelial Cells; Engineering; Engineerings; Extracellular Signal-Regulated Kinase Gene; F-Actin; Family member; Fibroblasts; Filamentous Actin; Funding; GAP Proteins; GTPase-Activating Proteins; Genes, Cancer Suppressor; Genes, Neurofibromatosis 1; Genes, Onco-Suppressor; Genes, nf 1; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetically Engineered Mouse; Grafting, Bone Marrow; Hematopoietic; Hereditary Disease; Image; In Vitro; Individual; Inflammatory; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; Knockout Mice; Life; Link; MAP Kinase Gene; MAPK; MGF Stem Cell Factor; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Mammary Glands, Human; Mammary gland; Marrow Mast Cell; Marrow Transplantation; Mast Cell Growth Factor; Mediating; Metabolic Networks; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microtubules; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Molecular Disease; Molecular Target; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Neurofibromas; Murine; Mus; Mutation; Myelopoiesis; NF-1 Protein; NF-1 encoded protein; NF1 GRP; NF1 Protein; NF1 gene; NF1-GAP-Related Protein; Neurilemma Cell; Neurilemmal Cell; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis 1; Neurofibromatosis I; Neurofibromatosis Syndrome; Neurofibromatosis Type 1 Gene Product; Neurofibromatosis Type 1 Protein; Neurofibromatosis, Peripheral, NF 1; Neurofibromatosis, Peripheral, NF1; Neurofibromatosis, Type 1; Neurofibromatosis, Type I; Neurofibromin; Neurofibromin 1; Neuromas, Plexiform; Non-Malignant; Null Mouse; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Pachydermatocele; Pancreas Cancer; Pancreatic Cancer; Pathologic; Patients; Peripheral Neurofibromatosis; Plexiform Neurofibroma; Predisposition; Process; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; Ras Signaling Pathway; Recklinghausen Disease of Nerve; Recklinghausen's disease; Recklinghausen's neurofibromatosis; Recruitment Activity; Research Personnel; Researchers; Role; Schwann Cells; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Steel Factor; Stem Cell Factor; Subcellular Process; Susceptibility; Testing; Threonine Kinase; Tumor Royale; Tumor Suppressing Genes; Tumor Suppressor Genes; abstracting; biological signal transduction; c-kit Ligand; cancer progression; gene product; genetic disorder; genome mutation; guanosinetriphosphatase activating protein; hereditary disorder; imaging; in vivo; insight; kit Ligand; malignancy; mammary; man; man's; mast cell; mastocyte; migration; neoplasm progression; neoplasm/cancer; neoplastic progression; neurofibroma; neurofibromatosis type 1 gene; neurofibromatosis type 1 protein/gene; nonmalignant; oncosuppressor gene; p21-activated kinase 1; prevent; preventing; recruit; small molecule; social role; tumor; tumor progression; von Recklinghausen Disease",Neurofibromatosis type 1 Gene Regulates Myelopoiesis,,74177,HP,Hematopoiesis Study Section,,13,324865,
7795080,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA075080-12,,NCI:304373;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"BALDWIN, ALBERT SIDNEY;",1865037;,5R01CA075080,04/01/1998,01/31/2014,"AKT; ATF; Adenocarcinoma; Adenoma, Malignant; Agents, Cytostatic; Akt protein; Animal Cancer Model; Animal Model; Animal Models and Related Studies; AnimalModel; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Astrocytoma, Grade IV; Automobile Driving; BZS; Birds of Prey; Cancer Model; Cancer Treatment; Cancer of Prostate; CancerModel; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Complex; Cytostatic Drugs; Cytostatics; Data; Development; Drivings, Automobile; Drugs; EC 2.7; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family; Feedback; GFAC; Gene Expression; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genital System, Male, Prostate; Glioblastoma; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Growth Agents; Growth Factor; Growth Factor Receptors; Growth Factors, Proteins; Growth Substances; Human; Human Prostate; Human Prostate Gland; Human, General; Humulin R; Immunoglobulin Enhancer-Binding Protein; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; MHAM; MMAC1; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Measures; Medication; Modeling; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Mutation; NF-kB; NF-kappa B; NF-kappaB; NFKB; Novolin R; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nutrient; Oncogenesis; Oncogenic; Outcome; PC3 cell line; PKB protein; PTEN; PTEN gene; PTEN1; Paper; Pathogenesis; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatase and Tensin Homolog; Phosphorylation; Phosphotransferases; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Protein Kinase B; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene, Growth Factor Receptor; Publishing; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Raptors; Receptor Protein; Regulation; Relative; Relative (related person); Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; TSC2; TSC2 gene; Testing; Therapeutic; Tissue Growth; Transcription Factor NF-kB; Translations; Transphosphorylases; Tumor Cell; Tumor Suppressor Proteins; Tumor of the Prostate; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; activating transcription factor; analog; anticancer therapy; base; biological signal transduction; c-akt protein; cancer cell; cancer progression; cancer therapy; cell growth; clinical relevance; clinically relevant; cytokine; cytotoxic; driving; drug/agent; experiment; experimental research; experimental study; fork head protein; forkhead protein; forkhead transcription factors; gene product; genome mutation; glioblastoma multiforme; human FRAP1 protein; in vitro Assay; inhibition of autophagy; inhibitor; inhibitor/antagonist; kappa B Enhancer Binding Protein; mTOR; mTOR inhibition; malignancy; model organism; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; nuclear factor kappa beta; ontogeny; p65; pathway; prostate cancer cell line; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; receptor; receptor upregulation; reconstitute; reconstitution; related to A and C-protein; research study; resistant; response; social role; spongioblastoma multiforme; transcription factor; tumor; tumor growth; tumor progression; tumor suppressor; tumorigenesis","Cancer-Associated, Interdependent Regulation of mTOR, AKT, and IKK/NF-kappaB"," Project Narrative Deregulated of Akt is implicated in the pathogenesis of a number of cancers. Based on this, the Akt pathway has emerged as a key regulator of oncogenesis and cancer therapy resistance in a variety of tumors. Akt functions to promote growth and survival through upregulation of mTOR and through mTOR-independent pathways, which include phosphorylation of targets which control apoptosis. Targeting mTOR with rapamycin, or analogs, is efficacious in some tumors but ineffective in many others due, in part, to loss of a negative feedback control on IRS-1 which then leads to Akt activation. Based on these observations, the development of inhibitors that blocks both mTOR and Akt activation may prove effective in a number of cancers. We have recently published that IKK¨ is a key regulator of mTOR (TORC1) in Akt-active cancer cells. Additionally, we find that mTOR (TORC1) regulates IKK/NF-¨B activity to induce expression of genes associated with cancer therapy resistance, demonstrating a novel function for the rapamycin-sensitive form of mTOR. We have now shown that IKK¨ associates with the TORC2 complex to regulate its ability to control Akt activity. Experiments are proposed to dissect the mechanism whereby IKK¨ regulates TORC2 activity in cancer cells and potentially downstream of growth factor-induced signaling. We hypothesize that inhibition of IKK¨ (using genetic and pharmacologic approaches) will block progression of cancers that depend on Akt and mTOR and will overcome cancer therapy resistance to rapamycin. Cell-based and animal model studies are proposed to test our hypotheses. The work is clinically relevant based on the following points: (i) we propose the use of a PTEN fl/fl model for prostate cancer which mimics the loss of PTEN seen in human cancers, including prostate cancer, (ii) the studies may reveal a mechanism to significantly and broadly enhance the efficacy of rapamycin by suppressing the downstream effects associated with the loss of feedback control on IRS-1 when TORC1 is inhibited, (iii) these studies will be the first to use a highly specific IKK¨ inhibitor in cancer models, (iv) we analyze primary human glioblastoma explants for therapeutic and mechanistic studies to test/validate our hypotheses, and (v) the results may reveal a single mechanism to simultaneously suppress TORC1 activity and Akt activation (via TORC2) in cancer.",75080,TCB,Tumor Cell Biology Study Section,,12,304373,
7795082,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA076329-13,,NCI:394734;,2010,NATIONAL CANCER INSTITUTE,,BRONX,UNITED STATES,ANATOMY/CELL BIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"EDELMANN, WINFRIED ;",7276844;,5R01CA076329,12/01/1997,01/31/2013,"ATP phosphohydrolase; ATPase; Abscission; Adenocarcinoma; Adenoma, Malignant; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Biochemical; Biological Function; Biological Process; Body Tissues; Cancer Cause; Cancer Etiology; Cancers; Cell Communication and Signaling; Cell Cycle Arrest; Cell Death, Programmed; Cell Extracts; Cell Signaling; Colon Cancer, Familial Nonpolyposis; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Repair Deficiency; DNA Repair Disorder; DNA lesion; Defect; Deoxyribonucleic Acid; Development; Diet; ES cell; Embryo; Embryonic; Event; Excision; Exposure to; Extirpation; Familial Non-Polyposis Colon Cancer (hMSH2, hMLH1, hPMS1, hPMS2); Fibroblasts; Frequencies (time pattern); Frequency; Funding; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genome Stability; Genomics; Genotoxins; HNPCC; Hereditary Colorectal Endometrial Cancer Syndrome; Hereditary Defective Mismatch Repair Syndrome; Hereditary Non-Polyposis Colon Cancer; Hereditary Non-Polyposis Colon Cancer (hMSH2, hMLH1, hPMS1, hPMS2); Hereditary Nonpolyposis Colon Cancer; Hereditary Nonpolyposis Colorectal Cancer; Hereditary Nonpolyposis Colorectal Neoplasms; Homolog; Homologous Gene; Homologue; Human; Human, General; Imaging Procedures; Imaging Techniques; Individual; Intestinal; Intestinal Mucosa; Intestines; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knockout Mice; Lead; Lesion; Lynch Syndrome; MMR; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mismatch Repair; Missense Mutation; Modeling; Molecular; Murine; Mus; Mutagens; Mutant Strains Mice; Mutation; Mutation, Missense; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Nucleotides; Null Mouse; Oncogenesis; Oxidative Stress; Pathway interactions; Pb element; Phenotype; Post-Replication Mismatch Repair; Pre-Clinical Model; Preclinical Models; Predisposition; Process; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Reaction; Removal; Repair Complex; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Splenocyte; Stability, Genomic; Staging; Surgical Removal; Susceptibility; Syndrome; System; System, LOINC Axis 4; Technics, Imaging; Tissues; Tumor Suppression; Tumor Suppression, Molecular; Unscheduled DNA Synthesis; Zeugmatography; base; biological signal transduction; bowel; cancer progression; embryonic stem cell; gene product; genome mutation; genome, mammalian; genotoxic agent; heavy metal Pb; heavy metal lead; hereditary non-polyposis colorectal cancer; in vivo; insight; loss of function mutation; malignancy; mammalian genome; mouse mutant; mutant; mutant mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; oxidative DNA damage; pathway; prevent; preventing; programs; public health relevance; repair; repaired; resection; response; social role; stem cell of embryonic origin; transversion mutation; tumor; tumor progression; tumorigenesis; villin",DNA mismatch repair and cancer in murine models,,76329,CE,Cancer Etiology Study Section,,13,394734,
7786238,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA077204-11,,NCI:282753;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MISCELLANEOUS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"POWIS, GARTH ;",1873277;,5R01CA077204,12/18/1998,01/31/2014,"1-acyl-sn-glycerol-3-phosphate; 1-oleoyl-lysophosphatidic acid; Angiogenic Factor; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptotic; Cancer Cell Growth; Cancer Drug; Cancers; Cell Communication and Signaling; Cell Death; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapeutic Agents, Neoplastic Disease; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Colorectal Cancer; Correlative Study; Cysteine; Development; Drosophila; Drosophila genus; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug effect disorder; Endoplasmic Reticulum; Ergastoplasm; FGF-2; FGF2; Factor, Angiogenesis; Family member; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Flies; Fruit Fly, Drosophila; GFAC; Generalized Growth; Genes; Genetic; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF-2; HSP; Half-Cystine; Heat shock proteins; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Human; Human, General; In Vitro; Intracellular Communication and Signaling; L-Cysteine; LPA; Lysophosphatidic Acids; Lysophospholipids; MOPA; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mercaptans; Mercapto Compounds; Modification; Molecular Target; Oxidation-Reduction; Pathway interactions; Patients; Phase 2 Clinical Trials; Phase II Clinical Trials; Phosphorylation; Polyamine Compound; Polyamines; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prostate Epithelial Cell Growth Factor; Prostatropin; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA, Small Interfering; Redox; Regulation; Research Design; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Small Interfering RNA; Stress; Stress Proteins; Study Type; Subcellular Process; Sulfhydryl Compounds; Testing; Thiols; Thioredoxin; Tissue Growth; Translations; TrxR2 enzyme; Tumor-Specific Treatment Agents; VEGFs; Vascular Endothelial Growth Factors; Vegf; Work; anticancer agent; anticancer drug; bFGF; base; biological signal transduction; cancer cell; clinical investigation; drug action; drug discovery; experience; fly; fruit fly; gene product; in vivo; inhibitor; inhibitor/antagonist; lysophosphatidic acid; malignancy; monooleylphosphatidate; monooleylphosphatidic acid; necrocytosis; neoplasm/cancer; novel; ontogeny; oxidation; oxidation reduction reaction; pathway; phase 2 study; phase 2 trial; phase II trial; pleurotin; protocol, phase II; public health relevance; response; siRNA; social role; stress protein; study design; study, phase II; sulfhydryl group; thioredoxin reductase; thioredoxin reductase 2; tumor; tumor growth",Redox Signaling and Cancer Drug Action," PROJECT NARRATIVE We propose that altered oxidation (redox) states of key cellular proteins that provide growth signals to cancer cells is responsible for their unregulated growth. The studies are designed to identify new redox pathways based on results of genetic studies in flies, studies of the effects of human genes on the pathways and the effects of redox stress on cancer cell growth. The role of the pathways in human cancer will be confirmed to allow the identification of new molecular targets for cancer drug discovery and new strategies to treat cancer.",77204,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,11,282753,
7793472,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA077712-12,,NCI:390285;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"HANAWALT, PHILIP COURTLAND;",1869417;,5R01CA077712,05/05/1998,01/31/2014,"7H-Furo(3,2-g)(1)benzopyran-7-one; ADAR1; Adopted; Apoptosis; Apoptosis Pathway; Assay; B-DNA; BTF2 transcription factor; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Cancer Induction; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Extracts; Cell Signaling; Cells; Chemicals; Complex; DNA; DNA Alteration; DNA Nicking-Closing Protein; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Sequence; DNA Structure; DNA Topoisomerase I; DNA Topoisomerases, Type I; DNA Type 1 Topoisomerase; DNA Untwisting Enzyme; DNA Untwisting Protein; DNA mutation; DNA, B Form; DNA, Z-Form; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Deoxyribonucleic Acid; Development; Drugs; EC 2.7.7.6; Excision Repair; Ficusin; G-Quadruplex; G-Quadruplexes DNA; G-Quartet Structures; G-Quartets; G-Tetrads; G4-DNA; Gene Action Regulation; Gene Alteration; Gene Expression Regulation; Gene Mutation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Transcription; Genetic defect; Genetic mutation; Genetics, Human; Genetics-Mutagenesis; Genome Instability; Genome Stability; Genomic Instability; H-DNA; Hereditary Disease; Homolog; Homologous Gene; Homologue; Hot Spot; Hot Spots (Area of Increased Mortality); Human; Human Genetics; Human, General; Hybrids; In Vitro; Initiation Factors; Intracellular Communication and Signaling; Lead; Learning; Left-Handed DNA; Lesion; Ligands; MMR; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Medication; Mismatch Repair; Mitochondria RNA; Mitochondrial RNA; Modeling; Molecular Biology, Mutagenesis; Molecular Disease; Molecular Interaction; Mutagenesis; Mutation; Nucleic Acid Binding; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Outcome; PNA; Pathway interactions; Pb element; Peptide Initiation Factors; Peptide Nucleic Acids; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmids; Post-Replication Mismatch Repair; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Psoralen; Psoralene; Psoralens; RNA Expression; RNA Polymerases; RecQ protein; Repair, Excision; Research; Right-Handed DNA; Role; SII transcription elongation factor; Scanning; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stability, Genomic; Structure; System; System, LOINC Axis 4; T7 RNA polymerase; TFIIH; TFIIS; TFIIS elongation factor; Targetings, Gene; Testing; Topoisomerase; Topoisomerase I; Transcription; Transcription, Genetic; Transcription-Coupled Nucleotide Excision Repair; Transcription-Coupled Repair; Translation Initiation Factor; Translational Initiation Factor; Trinucleotide Repeats; Triplet Repeats; Type I DNA Topoisomerases; Z-DNA; Z-DNA Binding Protein; Z-Form DNA; adduct; basic transcription factor 2; biological signal transduction; carcinogenesis; chemotherapy; codon reiteration; cross-link; crosslink; design; designing; drug/agent; elongation factor SII; experiment; experimental research; experimental study; gene product; genetic disorder; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; human disease; improved; in vivo; malignancy; mtRNA; neoplasm/cancer; new approaches; nicking closing enzyme; novel; novel approaches; novel strategies; novel strategy; nuclease; pathway; public health relevance; relaxing enzyme; repair endonuclease; repair enzyme; research study; response; social role; strand transfer protein alpha; swivelase; transcription elongation factor A; transcription elongation factor S-II; transcription factor; transcription factor IIH; transcription factor IIS; transcription factor S-II; transcription factor TFIIH; untwisting enzyme; zDNA",Role of transcription in genomic stability," Project Narrative The results from this project will enhance our understanding of the roles of transcription and TCR in processing lesions and other abnormalities in DNA that have been implicated in human disease. Since prolonged transcription arrest generates a strong signal for apoptosis, the research may lead to novel modes of chemotherapy, involving selective inhibition of TCR in target cells combined with administration of transcription-blocking drugs.",77712,CE,Cancer Etiology Study Section,,12,390285,
7778260,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA078810-13,,NCI:301726;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,BIOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"ALTIERI, DARIO C.;",1886802;,5R01CA078810,07/01/1998,02/28/2014,"API4; Adhesion Molecule; Anchorage-Independent Growth; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Apoptosis Regulator; Apoptotic; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Binding; Binding (Molecular Function); Biology; Cancer of Breast; Cancers; Cell Adhesion; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Death; Cell Death Inhibition; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cellular Adhesion; Cold-Insoluble Globulins; Complex; Cytosol; DISSEC; Deposit; Deposition; Disease; Disorder; Dissection; Disseminated Malignant Neoplasm; Distant; EC 2.7; EGFR; EPR-1; ERBB Protein; ERBB1; Elements; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epithelial; Exhibits; Extracellular Matrix Proteins; Extracellular Matrix, Integrins; FN1; FNZ; Fibronectin 1; Fibronectins; Foundations; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genetic; Global Change; Growth Factor Receptors; HER1; Heterograft; Human; Human, General; IAP-like protein, human; IAP4; In Vitro; Integrins; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; LETS Proteins; Large External Transformation-Sensitive Protein; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MMPs; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Maps; Matrix Metalloproteinases; Mediating; Mesenchymal; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Tumor; Mice, Transgenic; Mitochondria; Molecular; Molecular Analysis; Molecular Interaction; Neoplasm Metastasis; Oncogenesis; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Organ; Organelles; PRKM8; Pathway interactions; Phosphotransferases; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein-Tyrosine Kinases, src; Proteins; Proto-Oncogene, Growth Factor Receptor; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Role; SAPK1; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Structure; Testing; Transforming Growth Factor alpha Receptor; Transgenic Mice; Transgenic Model; Transphosphorylases; Transplantation, Heterologous; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Up-Regulation; Up-Regulation (Physiology); Upregulation; X-linked IAP; XIAP protein; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; alpha 2-Surface Binding Glycoprotein; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cancer metastasis; cancer progression; cell adhesion protein; cultured cell line; design; designing; disease/disorder; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; extracellular; gene product; genetically modified cells; hILP protein; in vivo; in vivo Model; malignancy; malignant breast neoplasm; mitochondrial; mouse model; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; pathway; programs; proto-oncogene protein c-erbB-1; public health relevance; research study; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; survivin; tumor growth; tumor progression; tumorigenesis; x-linked IAP protein",Control of Apoptosis in Cancer by Survivin," PROJECT NARRATIVE  The dissemination of tumor cells to distant organs, or metastasis, is a deadly occurrence in cancer progression, but its underlying mechanisms are still largely obscure. The present proposal will dissect a novel pathway of metastasis, involving interplay between regulators of cell survival and cell adhesion. The results may open new prospects for the treatment of metastatic cancer, which is currently incurable.",78810,TPM,Tumor Progression and Metastasis Study Section,,13,301726,
7755813,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA079827-08,,NCI:240133;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,ENGINEERING (ALL TYPES),08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"SAMSON, LEONA D;",6141301;,5R01CA079827,02/25/1999,01/31/2012,"1H-Purin-6-amine; Adenine; Alkylating Agents; Alkylation; Alkylators; Allelic Loss; Animals; Base Excision Repairs; Base Pairing; Body Tissues; Cancer Cause; Cancer Etiology; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chemicals; Chronic; Clonal Expansion; Code; Coding System; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA N-glycosidase; DNA Recombination; DNA Repair; DNA Sequence Rearrangement; DNA glycosylase; DNA lesion; DNA recombination (naturally occurring); Death; Direct Repeats; Double Strand Break Repair; Environmental Factor; Environmental Risk Factor; Event; Excision Repair; Exposure to; Face; Frequencies (time pattern); Frequency; Gastrointestinal Tract, Pancreas; Genetic; Genetic Recombination; Genome Instability; Genomic Instability; Goals; Grant; INFLM; In Vitro; Inflammation; Inflammatory; Intracellular Communication and Signaling; Investigators; Knowledge; Large-Scale Sequencing; Lead; Learning; Length; Lesion; Light; Loss of Heterozygosity; MNU; MTGN; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammalian Cell; Mammals, Mice; Methylnitrosourea; Mice; Mitogens; Modeling; Molecular; Murine; Mus; N-Methyl-N-nitrosourea; Nitrosomethylurea; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pathway interactions; Pb element; Persons; Photoradiation; Predisposition; Process; Programs (PT); Programs [Publication Type]; Proteins; Rearrangement; Recombinants; Recombination; Recombination, Genetic; Relative; Relative (related person); Repair, Excision; Repairs, Base Excision; Repeats, Direct; Research Personnel; Researchers; Risk Factors; Signal Transduction; Signal Transduction Systems; Signaling; Site; Subcellular Process; Susceptibility; Testing; Time; Tissues; Transgenic Animals; Unscheduled DNA Synthesis; Urea, N-methyl-N-nitroso-; Vitamin B4; Work; anticancer therapy; base; biological signal transduction; cancer prevention; cancer risk; cancer therapy; chronic pancreatitis; environmental risk; facial; gene product; heavy metal Pb; heavy metal lead; homologous recombination; in vivo; interest; malignancy; mutant; neoplasm/cancer; overexpression; pathway; programs; reconstitute; reconstitution; recurrent pancreatitis; repair; repair endonuclease; repair enzyme; repaired; tumorigenic","""Mechanisms of Damage-Induced Homologous Recombination""",,79827,CE,Cancer Etiology Study Section,,8,240133,
7783846,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA079882-11,,NCI:299617;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,PHARMACOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SIEGFRIED, JILL M;",1886201;,5R01CA079882,08/12/1999,01/31/2014,"ATP[{..}]protein-tyrosine O-phosphotransferase; American; Antibodies; Biological; Biological Testing; COX-2 protein; COX2; COX2 enzyme; COX2 inhibitor; CSBP1; CSBP2; CSPB1; Cancer Induction; Cancer Patient; Cancer Treatment; Cancer of Lung; Cancers; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cellular Proliferation; Clinical; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Complex; Coxibs; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Development; Diagnosis; Dinoprostone; Drug Industry; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR-TK Inhibitor; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; EXIP; Elements; Engraftment; Environment; Enzymes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Exhibits; Extracellular Signal-Regulated Kinase Gene; Forecast of outcome; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Grant; Growth; HEK3; HER1; HGF Receptor; HGF protein, human; HGF/SF; HPTA protein, human; Hepatocyte Growth Factor; Hepatocyte Growth Factor Receptor; Hepatopoietin; Hepatopoietin A; Human; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Industry, Pharmaceutic; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Isotopes; Killings; LFDM protein, human; Laboratories; Ligands; Lung; Lung Fibroblast-Derived Mitogen; Lung Neoplasms; Lymphokines and Cytokines, scatter factor; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Modeling; Mouse Strains; Murine; Mus; Mutation; Mxi2; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Oncogenesis; Outcome; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PRKM14; PRKM15; PTGS2; PTK; PTK Receptors; Pathway interactions; Pharmaceutical Industry; Phase; Phosphorylation; Pre-Clinical Model; Preclinical Models; Predisposition; Prognosis; Progress Reports; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proto-Oncogene Protein c-met; PubMed; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; RTK; Receptor Activation; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Reports, Progress; Research; Resistance; Respiratory System, Lung; SAPK2A; Scatter Factor; Scatter Factor Receptor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Susceptibility; Tail; Testing; Therapeutic; Tissue Growth; Tobacco-Associated Carcinogen; Transforming Growth Factor alpha Receptor; Transgenic Animals; Transgenic Mice; Transgenic Organisms; Transmembrane Receptor Protein Tyrosine Kinase; Tumor Tissue; Tumor of the Lung; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Veins; Work; Wound Healing; Wound Repair; angiogenesis; anticancer therapy; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; c-met Protein; cancer cell; cancer therapy; cancer type; carcinogenesis; clinical test; cultured cell line; cyclo-oxygenase II; cyclooxygenase 2; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene product; genome mutation; hepapoietin A protein, human; hepatocyte growth factor, human; human HGF protein; hydroxyaryl protein kinase; immunosuppressed patient; inhibitor; inhibitor/antagonist; lung cancer; lung tumorigenesis; lung-fibroblast-derived mitogen protein, human; malignancy; meetings; mutant; neoplasm/cancer; neutralizing antibody; nonsmall cell lung cancer; ontogeny; outcome forecast; p190 (MET); p38; p38 MAPK Gene; p38Alpha; paracrine; pathway; pre-clinical; preclinical; preclinical study; prognostic indicator; prostaglandin H synthase-2; protein activation; proto-oncogene protein c-erbB-1; public health relevance; pulmonary; receptor; research clinical testing; resistant; response; scatter factor, human; tissue repair; transgenic; tumor; tumor growth; tumorigenesis; tumorigenic; tyrosyl protein kinase",Targeting the HGF/c-Met Pathway in Lung Cancer," Project Narrative Lung cancer kills more Americans every year than any other type of cancer. Lung cancer typically is diagnosed at a late stage and does not respond well to current treatments. This project will investigate a new pathway, the HGF/c-Met pathway, that controls lung cancer growth. In this project we will test different mechanisms by which the HGF/c-Met pathway controls the activity of other growth-promoting proteins in lung cancer cells, in order to understand how to inhibit this pathway most effectively.",79882,DT,Developmental Therapeutics Study Section,,11,299617,
7761698,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA080757-12,,NCI:334226;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,GENETICS,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"RAVETCH, JEFFREY VICTOR;",1888738;,5R01CA080757,03/05/1999,12/31/2013,"ADCC; APC; ARAM; ATGN; Accounting; Active immunity; Address; Adjuvant; Ag Recognition Activation Motif; Animals; Antibodies; Antibodies, Neoplasm; Antibodies, Tumor; Antibody -dependent cell cytotoxicity; Antibody Formation; Antibody Production; Antibody Response; Antibody-Dependent Cellular Cytotoxicity; Antigen Presentation; Antigen-Antibody Complex; Antigen-Presenting Cells; Antigens; Binding; Binding (Molecular Function); Biological; Bp50; CAS2; CATB; CD40; CDW40; Cell Communication and Signaling; Cell Cytoxicity, Antibody-Dependent; Cell Mediated Immunology; Cell Signaling; Cell-Mediated Immunity; Cellular Immunity; Chimera Protein; Chimeric Proteins; Clinical; Coupled; Dendritic Cells; Development; Disease; Disorder; Edodekin Alfa; Effector Cell; Engineering; Engineerings; Family; Fc Receptor; FcR; Fusion Protein; GP75; Gamma Globulin, 7S; IL-12; IL12; ITAM; IgG; IgG1; Immune Complex; Immunity; Immunity, Cellular; Immunoglobulin G; Immunologic Accessory Cells; Immunoreceptor Tyr-Based Activation Motif; Immunoreceptor Tyrosine-Based Activation Motif; In Vitro; Individual; Interleukin-12; Intracellular Communication and Signaling; Knock-out; Knockout; Knowledge; Ligands; MGC9013; Malignant Melanoma; Mammals, Mice; Mediating; Melanosomes; Mice; Modality; Modeling; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Neoplasm Antibodies; Pathway interactions; Patients; Play; Relative; Relative (related person); Role; Sampling; Series; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; T-Cell Activation; T-Cells; T-Lymphocyte; TNFRSF5; TNFRSF5 gene; TRP; TYRP1; TYRP1 gene; Therapeutic; Therapeutic Effect; Thymus-Dependent Lymphocytes; Tumor Antibodies; Tumor Antigens; Tumor Cell; Tumor Immunity; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Tumor-Associated Antigen; Vaccination; Variant; Variation; Veiled Cells; accessory cell; anergy; antibody biosynthesis; antibody dependent cell mediated cytotoxicity; antibody engineering; antibody receptor; antitumor antibody; base; biological signal transduction; cancer progression; cytokine; cytotoxic; disease/disorder; immunogen; immunogenic; immunoglobulin biosynthesis; improved; in vivo; macrophage; melanoma; mouse model; neoplasm progression; neoplastic cell; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; p50; pathway; public health relevance; response; social role; subcutaneous; thymus derived lymphocyte; tumor; tumor progression; tumor-specific antigen; uptake; vector",Molecular Aspects of Antitumor Antibodies, PROJECT NARRATIVE Anti-tumor antibodies have emerged as a significant clinical modality in the treatment of metastatic disease. Improving and extending the activity of these antibodies requires a detailed knowledge of their mechanism of action. The studies proposed will elucidate the relative contributions of macrophages and dendritic cells to the in vivo activity of anti-melanoma antibodies and will explore a novel approach to inducing active immunity to melanoma by directly targeting dendritic cells with a melanosome antigen.,80757,CII,Cancer Immunopathology and Immunotherapy Study Section,,12,334226,
7828241,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA080830-12,,NCI:325122;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SWEASY, JOANN B;",8183234;,5R01CA080830,04/07/1999,02/28/2014,"5'-deoxyribose phosphate lyase; Abscission; Active Sites; Address; Affect; Amino Acids; Assay; Base Excision Repairs; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cancers; Cells; Cellular Transformation; DNA; DNA Base Excision Repair; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Damage Repair; DNA Injury; DNA Polymerase IV; DNA Polymerase beta; DNA Repair; DNA Replication; DNA Synthesis; DNA biosynthesis; Deoxyribonucleic Acid; Distant; Enzymes; Excision; Extirpation; Fluorescence; Funding; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genetics-Mutagenesis; Genome Stability; Goals; Human; Human, General; Kinetic; Kinetics; Lead; Learning; Lesion; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods; Molecular; Molecular Biology, Mutagenesis; Motion; Mutagenesis; Mutation; Nucleotides; Pb element; Play; Position; Positioning Attribute; Prevention; Proteins; Removal; Repairs, Base Excision; Research; Role; Sites, Active; Solutions; Stability, Genomic; Structure; Surgical Removal; Testing; Thumb; Thumb structure; Unscheduled DNA Synthesis; Variant; Variation; aminoacid; dRP lyase; design; designing; enzyme structure; gene product; genome mutation; heavy metal Pb; heavy metal lead; immortalized cell; malignancy; metaplastic cell transformation; mutant; neoplasm/cancer; prevent; preventing; public health relevance; resection; social role; tumor",DNA Polymerase Beta and Mutagenesis, Project Narrative The goal of this application is to determine why enzymes that copy DNA make mistakes. The mistakes made by these enzymes can become mutations and lead to cancer. Learning more about how these enzymes copy DNA and make mistakes will help us design new strategies to prevent and treat human cancer.,80830,RTB,Radiation Therapeutics and Biology Study Section,,12,325122,
7766904,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA080843-09,,NCI:330868;,2010,NATIONAL CANCER INSTITUTE,,HONOLULU,UNITED STATES,NONE,01,965088057,US,HI,96822,UNIVERSITY OF HAWAII AT MANOA,"MASKARINEC, GERTRAUD ;",1907203;,5R01CA080843,09/01/1999,02/28/2011,"Accounting; Address; Adherence; Adherence (attribute); Adverse effects; Affect; Androgenic Agents; Androgenic Compounds; Androgens; Aquadiol; Bean Curd, Soy; Blood; Blood Serum; Breast; Breast Diseases; Breast Disorder; Breast Tissue; Buffers; CYP; Cancer of Breast; Cells; Cellular Morphology; Chemotherapy-Hormones/Steroids; Clinical Trial Overviews; Consumption; Corpus Luteum Hormone; Counseling; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Crossover Design; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytochromes; Cytology; Data Pooling; Data Poolings; Delta4-pregnene-3,20-dione; Designs, Cross-Over; Development; Diet; Dimenformon; Diogyn; Diogynets; Disease Frequency Surveys; Endocrine Gland Secretion; Enzymes; Epithelial; Epithelial Cells; Equilibrium; Estra-1,3,5(10)-trien-17-one, 3-hydroxy-; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Metabolism; Estrogen Metabolism Alteration; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrone; Evaluation; Excretory function; Female breast; Freezing; Generalized Growth; Gifts; Goals; Gonadal Steroid Hormones; Grant; Growth; HMO; Health Maintenance Organizations; Hormonal; Hormones; Hour; Immunologic, Radioimmunoassay; Intake; Isoflavones; Lead; Learning; Life; Linear Models; Liquid substance; Luteal Phase; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammographic Density; Measurement; Measures; Mediating; Menopausal Symptom; Menstrual Cycle, Luteal Phase; Menstrual Cycle, Secretory Phase; Menstrual Secretory Phase; Meta-Analyses; Meta-Analysis; Modification; Operation; Operative Procedures; Operative Surgical Procedures; Ovocyclin; Ovocylin; P450; Pathway interactions; Pattern; Pb element; Postovulatory Phase; Pre-Menopause; Pre-menopausal Period; Pregn-4-ene-3,20-dione; Pregnenedione; Premenopausal; Premenopausal Period; Premenopause; Prepaid Group Health Organizations; Prevention; Preventive; Procedures; Progesterone; Progynon; Publications; Publishing; RIA; Radioimmunoassay; Randomized; Recruitment Activity; Regimen; Relative; Relative (related person); Reporting; Research Design; Reticuloendothelial System, Blood; Risk; Role; Sampling; Scientific Publication; Serum; Sex Hormones; Sex Steroid Hormones; Soy Bean Curd; Soy Foods; Soy Isoflavone; Soybean Protein Isolate; Steroid Compound; Steroids; Study Type; Surgical; Surgical Interventions; Surgical Procedure; Testing; Therapeutic Androgen; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Estrone; Therapeutic Hormone; Therapeutic Progesterone; Time; Tissue Growth; Tofu; Treatment Side Effects; Urinary System, Urine; Urine; Woman; aged; balance; balance function; biomarker; breast density; cancer prevention; cancer risk; cell morphology; excretion; fluid; gonadal steroids; heavy metal Pb; heavy metal lead; intervention effect; liquid; malignant breast neoplasm; mammary disorder; nipple aspirate fluid; ontogeny; pathway; pre-menopausal; protective effect; randomisation; randomization; randomly assigned; recruit; sex steroid; side effect; social role; soy; soy protein isolate; study design; surgery; therapy adverse effect; treatment adverse effect; urinary",Effects of Soy on Estrogens in Breast Fluid and Urine,,80843,EPIC,Epidemiology of Cancer Study Section,,9,330868,
7752496,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA081063-11,,NCI:269535;,2010,NATIONAL CANCER INSTITUTE,,GALVESTON,UNITED STATES,BIOCHEMISTRY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"MITRA, SANKAR ;",1867595;,5R01CA081063,04/01/1999,01/31/2012,"5'-Hydroxylpolynucleotide Kinase; 7,8-dihydro-8-oxoguanosine; 8-hydroxyguanosine; 8-oxo-7,8-dihydroguanosine; 8-oxoG; 8-oxoGuo; 8-oxoguanosine; AP Endonuclease; AP Lyase; ATP[{..}]5'-dephosphopolynucleotide 5'-phosphotransferase; Abscission; Acetylation; Active Oxygen; Affect; Aging; Amines; Apurine-Apyrimidine Endonuclease; Apurinic DNA Endonuclease; Apurinic Endonuclease; BLM Protein; Base Excision Repairs; Bloom syndrome protein; Bone structure of ilium; Cancer Radiotherapy; Cancers; Cell Nucleus; Cells; Complex; Cricetinae; DNA; DNA 5'-Hydroxylkinase; DNA Base Excision Repair; DNA Helicase, RECQ-Like, Type 2; DNA Helicases; DNA Joinases; DNA Kinase; DNA Ligases; DNA Lyase (Apurinic or Apyrimidinic); DNA N-glycosidase; DNA Nicking Enzyme; DNA Polymerases; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA glycosylase; DNA strand break; DNA unwinding enzyme; DNA-(apurinic or apyrimidinic site) lyase; DNA-Dependent DNA Polymerases; DNA-Dependent RNA Polymerase II; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; EC 2.7.7.7; Endodeoxyribonuclease (Apurinic or Apyrimidinic); Endonuclease I; Excision; Excision Repair; Extirpation; Flap Endonucleases; Funding; Gene Transcription; Genetic Transcription; Genome; Genomics; Genotoxins; Guanosine, 7,8-dihydro-8-oxo-; H2A Histone Family, Member X; H2A histone family, member X protein, human; H2A.X protein, human; H2A/X; H2AFX; H2AFX protein, human; H2AX; H2AX protein, human; Hamsters; Health; Histone H2A.X; Histone H2AX; Homologous Recombinational Repair; Human; Human, General; Ilium; Immunoblotting; In Vitro; Intervention; Intervention Strategies; Kinetic; Kinetics; Lesion; MMH Gene; MMR; MUTM Gene; Macromolecular Protein Complexes; Malignant Neoplasms; Malignant Tumor; Mammals, Hamsters; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mismatch Repair; Modification; Multiprotein Complexes; Murine; Mus; Mutagens; N-Glycosylase/DNA Lyase Gene; Nickase; Nuclear; Nuclear Translocation; Nucleotides; Nucleus; OGG1; OGG1 gene; OGH1 Gene; Oxidative Stress; Oxygen Radicals; Pathway interactions; Phase; Phenotype; Plasmids; Polydeoxyribonucleotide Ligases; Polydeoxyribonucleotide Synthetases; Polynucleotide 5'-Hydroxyl-Kinase; Polynucleotide Hydroxykinase; Polynucleotide Hydroxylkinase; Polynucleotide Kinase; Post-Replication Mismatch Repair; Pro-Oxidants; Proteins; Publications; RNA Expression; RNA Polymerase B; RNA Polymerase II; Radiation; Radiation therapy; Radiosensitization; Radiotherapeutics; Radiotherapy; Reactive Oxygen Species; Recombination Repair; Relative; Relative (related person); Removal; Repair Complex; Repair, Excision; Repairs, Base Excision; Respiration; Role; SS DNA BP; Scientific Publication; Senescence; Single-Stranded DNA-Binding Protein; Site; Slide; Stress; Surgical Removal; Syndrome; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Transcription; Transcription, Genetic; Tumor Cell; adduct; base; experience; gene product; genome, mammalian; genotoxic agent; helicase; human H2AX protein; ilium; in vivo; innovate; innovation; innovative; intervention therapy; interventional strategy; irradiation; malignancy; mammalian genome; mutant; neoplasm/cancer; neoplastic cell; novel; overexpression; oxidative damage; pathway; plasmid DNA; preference; ray (radiation); recombinational repair; repair; repaired; resection; respiratory mechanism; response; senescent; social role; stoichiometry; tumor",Repair of Oxidized Bases in Mammalian Genomes,,81063,RTB,Radiation Therapeutics and Biology Study Section,,11,269535,
7763887,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA081595-09,,NCI:197518;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,PSYCHIATRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"BECKHAM, JEAN C;",1882238;,5R01CA081595,09/30/1998,02/28/2011,"21+ years old; Abstinence; Acoustic; Acoustics; Address; Adult; Affect; Agitation; Anxiety; Area; Attention; Attention Concentration; Award; Behavior; Behavioral; Behavioral Mechanisms; Cessation of Treatment; Cessation of smoking; Chronic; Cigarette; Cross-Product Ratio; Cues; Data; Development; Distress; Event; Excitement, Psychomotor; Exhibits; FLR; Failure (biologic function); Funding; Gender; Human, Adult; Individual; Investigators; Knowledge; Laboratories; Lead; Measures; Mechanisms of Behavior and Behavior Change; Medical; Mental disorders; Mental health disorders; Methods; Monitor; Moods; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Nicotine; Odds Ratio; PTSD; Patients; Pb element; Persons; Post-Traumatic Stress Disorders; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychomotor Agitation; Psychomotor Hyperactivity; Psychomotor Restlessness; Psychopathology; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Relapse; Relative Odds; Reporting; Research Personnel; Researchers; Restlessness; Risk; Risk Ratio; Sampling; Self Efficacy; Sex Characteristics; Sex Differences; Smoke; Smoker; Smoking; Smoking Behavior; Social Problems; Societies; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Survey Instrument; Surveys; Symptoms; Trauma; United States; Unspecified Mental Disorder; Vulnerable Populations; Withholding Treatment; Woman; Work; abnormal psychology; adult human (21+); cease smoking; cigarette smoking; distress tolerance; failure; gender difference; heavy metal Pb; heavy metal lead; help seeking; help-seeking behavior; improved; men; men's; mental illness; prepulse inhibition; programs; psychologic; psychological; psychological disorder; response; sexual dimorphism (noncellular); smoke cigarette; smoking cessation; smoking relapse; social disturbance; traumatic neurosis",Smoking & Anxiety In Posttraumatic Stress Disorder,,81595,ZRG1,Special Emphasis Panel,,9,197518,
7758793,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA082295-10,,NCI:256070;,2010,NATIONAL CANCER INSTITUTE,,MINNEAPOLIS,UNITED STATES,PATHOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"MCCARTHY, JAMES B.;",6964818;,5R01CA082295,04/01/2000,01/31/2011,"Adhesions; Adventitial Cell; Anchorage-Independent Growth; Assay; B-raf-1; BRAF; BRAF gene; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Biology; Blood Circulation; Bloodstream; Cell Adhesion; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Survival; Cell Viability; Cell surface; Cell-Extracellular Matrix; CellLine; Cells; Cellular Adhesion; Cellular Expansion; Cellular Growth; Cellular Migration; Chimera Protein; Chimeric Proteins; Chondroitin Sulfate Proteoglycan; Circulation; Core Protein; Cytoplasmic Domain; Cytoplasmic Tail; Docking; ECM; ERK 1; ERK1 Kinase; External Domain; Extracellular Domain; Extracellular Matrix; Extracellular Matrix Degradation; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinase 1; FAK; FAK1; Focal Adhesion Kinase 1; Funding; Fusion Protein; GFAC; Generalized Growth; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; In Vitro; Integrins; Intracellular Communication and Signaling; Lead; Lesion; Link; MAP Kinase 3; MAP-ERK Kinase; MAPK ERK Kinases; MAPK3 Mitogen-Activated Protein Kinase; MEKs; MMPs; Malignant; Malignant - descriptor; Malignant Melanoma; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediating; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Melanoma Cell; Metastasis; Metastasize; Metastatic Lesion; Metastatic Neoplasm; Metastatic Tumor; Microtubule-Associated Protein-2 Kinase; Mitogen-Activated Protein Kinase 3; Moab, Clinical Treatment; Modeling; Molecular; Molecular Interaction; Monoclonal Antibodies; Motility; Motility, Cellular; Mutate; Neoplasm Metastasis; P44MAPK; PSTkinase p44mpk; PTK2; PTK2 Protein Tyrosine Kinase 2; Pathway interactions; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Phosphorylation; Pre-Malignant; Precipitation; Premalignant; Primary Neoplasm; Primary Tumor; Protein Phosphorylation; Protein-Serine-Threonine Kinase p44(mpk); Proteoglycan; RAFB1; RNA, Small Interfering; Radial Growth Phase; Recombinant Fusion Proteins; Role; Rouget Cells; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Staging; Tail; Tissue Growth; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tyrosine Phosphorylation; Vertical Growth Phase; Xenograft Model; biological signal transduction; cancer metastasis; cancer progression; cell growth; cell motility; chondroitin sulfate proteoglycan core glycoprotein; cultured cell line; dermatan sulfate glycoprotein core protein; endogenous substrate pp120; extracellular; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; melanoma; member; migration; neoplasm progression; neoplastic cell; neoplastic progression; novel; ontogeny; p125(FAK); p125FAK; p44 (MAPK); p44 MAPK; pathway; pp125(FAK); pp125FAK; precancerous; protein expression; proteoglycan core protein; siRNA; social role; therapeutic target; tumor; tumor growth; tumor progression; v-raf Murine Sarcoma Viral Oncogene Homolog B1; vector",Melanoma Cell Surface Proteoglycans in Metastasis,,82295,ZRG1,Special Emphasis Panel,,10,256070,
7763171,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA082478-10,,NCI:297714;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"KAHL, STEPHEN B;",1898666;,5R01CA082478,03/01/2000,01/31/2011,"Absorption; B element; BNCT Agent; Biodistribution; Biological; Biological Testing; Boranes; Boron; Boron Compounds; Boron Delivery Agent; Boron Hydrides; Boron Neutron Capture Therapy; Boron Neutron Capture Therapy Agents; Boron Transport Agent; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Budgets; C element; Cancer Control; Cancer Control Science; Cancer Treatment; Cancer of Brain; Cancerous; Carbon; Cell Nucleus; Cells; Chemistry; Clinical; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Common Rat Strains; Convection; Country; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Goals; Grant; Health; Hematoporphyrins; Histopathology; Human; Human, General; In Vitro; Investigators; Judgment; LDL; Laboratories; Lead; Link; Lipoproteins, LDL; Literature; Location; Low-Density Lipoproteins; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Brain; Malignant neoplasm of brain; Mammals, Rats; Man (Taxonomy); Man, Modern; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Mediating; Medication; Methods; Molecular Weight; Morbidity; Morbidity - disease rate; Neoplasms of Neuroglia; Neuroglial Neoplasm; Neuroglial Tumor; Neutrons; Normal Cell; Normal Tissue; Normal tissue morphology; Nuclear; Nuclear Envelope; Nuclear Membrane; Nucleus; Nude Rats; Oncologist; Outcome; Patients; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Polyomavirus macacae; Polyomavirus maccacae 1; Porphyrins; Preparation; Process of absorption; Program Development; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publishing; Radiation; Rat; Rats, Athymic; Rats, Nude; Rattus; Reaction; Recombinants; Research Design; Research Personnel; Researchers; SV 40; SV 40 Virus; SV40; SV40 Virus; Science of Chemistry; Series; Simian Vacuolating Virus 40; Simian virus 40; Solid Neoplasm; Solid Tumor; Sound; Sound - physical agent; Structure; Study Type; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Trials; Therapy Clinical Trials; Time; Toxic effect; Toxicities; Toxicology; Toxin; Tumor Cell; Tumors of Neuroglia; Vacuolating Agent; Virus; Viruses, General; Work; absorption; aminoacid sequence of peptide; aminoacid sequence of protein; anticancer therapy; base; beta-Lipoproteins; cancer cell; cancer therapy; carborane; cell killing; cellular targeting; clinical investigation; design; designing; drug/agent; experience; heavy metal Pb; heavy metal lead; in vivo; irradiation; neoplastic cell; peptide sequence; polyol; porphyrin a; programs; protein aminoacid sequence; ray (radiation); sound; study design; tumor; tumors in the brain; vacuolating virus",Program for Development of BNCT Agents,,82478,ZRG1,Special Emphasis Panel,,10,297714,
7760593,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA082500-11,,NCI:283690;,2010,NATIONAL CANCER INSTITUTE,,MILWAUKEE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"SCHMAINDA, KATHLEEN MARIE;",1909763;,5R01CA082500,03/01/2000,01/31/2012,"Address; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Animals; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Blood - brain barrier anatomy; Blood Circulation; Blood Vessel Tumor; Blood Vessels; Blood Volume; Blood-Brain Barrier; Bloodstream; Body Tissues; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Caliber; Calibration; Cancer Radiotherapy; Cancer Staging; Cerebrovascular Circulation; Cerebrum; Circulation; Clinic; Clinical; Clinical Research; Clinical Study; Cognitive Discrimination; Combined Modality Therapy; Common Rat Strains; Contrast Agent; Contrast Drugs; Contrast Media; Detection; Diagnosis; Diagnostic Neoplasm Staging; Diameter; Discrimination; Discrimination (Psychology); Dose; Drugs; Effects of radiation; Encephalon; Encephalons; Evaluation; Extravasation; FDA approved; Goals; Hemato-Encephalic Barrier; Human; Human, General; Image; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Investigators; Leakage; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Methods; Methods and Techniques; Methods, Other; Microscopy; Modeling; Monitor; Morphology; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; NMR Imaging; NMR Tomography; Neoplasm Staging; Neoplasms in Vascular Tissue; Neovascularization Inhibitors; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Patients; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Predisposition; Programs (PT); Programs [Publication Type]; Radiation therapy; Radiopaque Media; Radiotherapeutics; Radiotherapy; Rat; Rattus; Recurrence; Recurrent; Research; Research Personnel; Researchers; Role; Simulate; Spillage; Staging; Susceptibility; T-Stage; Techniques; Testing; Therapeutic; Therapeutic Studies; Therapy Research; Time; Tissues; Translating; Translatings; Translations; Tumor Angiogenesis; Tumor Staging; Tumor stage; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Work; Zeugmatography; angiogenesis; antiangiogenic; base; blood vessel neoplasm; cerebral blood flow; cerebral circulation; cerebrocirculation; clinical practice; combination therapy; combined modality treatment; combined treatment; conventional therapy; drug/agent; effect, adverse, radiation; experiment; experimental research; experimental study; imaging; imaging modality; improved; interest; irradiation; language translation; models and simulation; multimodality therapy; novel; programs; radiation effect; research study; response; social role; success; treatment strategy; tumor; tumors in the brain; vascular",MRI Contrast Agent Methods of Assessing Tumor Angiogenesis,,82500,MEDI,Medical Imaging Study Section,,11,283690,
7763787,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA082659-12,,NCI:243280;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"LIN, DANYU ;",1968898;,5R01CA082659,04/01/2000,01/31/2012,"Address; Algorithms; Applied Research; Applied Science; Articulation; Cancers; Cations; Clinical; Complex; Computer Simulation; Computerized Models; Data; Data Analysis, Statistical; Data Interpretation, Statistical; Development and Research; Disease; Disease Association; Disorder; Environmental Factor; Environmental Risk Factor; Epidemiology; FLR; Failure (biologic function); Family; Family Study; General Population; General Public; Genetic; Genotype; Grant; Haplotypes; Hazard Models; Individual; Investigation; Investigators; Joints; Malignant Neoplasms; Malignant Tumor; Mathematical Model Simulation; Mathematical Models and Simulations; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; North Carolina; Performance; Population; Principal Investigator; Procedures; Process; Property; Property, LOINC Axis 2; R & D; R&D; Research; Research Personnel; Researchers; Sampling; Science of Statistics; Simulation, Computer based; Solutions; Sound; Sound - physical agent; Statistical Data Analyses; Statistical Data Interpretation; Statistical Methods; Statistics; Stratification; Structure; Survival Analyses; Survival Analysis; Techniques; Testing; Time; Universities; Work; anticancer research; association test; base; cancer research; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease/disorder; environmental risk; experience; failure; genetic association; in silico; malignancy; neoplasm/cancer; public health relevance; research and development; response; simulation; sound; statistics; theories; tool; trait; user friendly computer software; user friendly software; virtual simulation",Statistical Methods in Cancer Research,"PUBLIC HEALTH RELEVANCE: The broad, long-term objectives of this research are the developments of statistical methods for the designs and analysis of clinical and epidemiological cancer studies, with or without genetic components.",82659,BMRD,Biostatistical Methods and Research Design Study Section,,12,243280,
7768498,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA082783-10,,NCI:241297;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"PARSONS, RAMON E;",1872196;,5R01CA082783,03/03/2001,01/31/2011,"1-Phosphatidylinositol 3-Kinase; AKT; APO2L; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Acinus organ component; Activation, Gene; Akt protein; Alleles; Allelomorphs; Apo-2L; Attenuated; BZS; Binding Sites; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cancers; Cell Communication and Signaling; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chiro-Inositol; Chromatin; Combining Site; Complex; DNA; Data; Deoxyribonucleic Acid; Development; Diabetes Mellitus; Differentiation and Growth; Dose; Drosophila; Drosophila genus; EC 2.7; ERBB2; ERBB2 gene; Elements; Embryo Development; Embryogenesis; Embryonic Development; Enzymes; Family member; Flies; Frequencies (time pattern); Frequency; Fruit Fly, Drosophila; Funding; Gene Activation; Gene Targeting; Gene Transcription; General Transcription Factor Gene; Generalized Growth; Genes; Genes, HER-2; Genes, HER2; Genes, Suppressor; Genes, erbB-2; Genes, neu; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Grant; Growth; HER -2; HER-2; HER2; HER2/neu; Homo sapiens; Human; Human EGF Receptor 2 Gene; Human, General; Humulin R; IGF Receptor; INSR; IRS2; IRS2 gene; Immunologic, Luciferase; Incidence; Inositide Phospholipids; Inositol; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Insulin-Like Growth Factor Receptor; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Kinases; Ligands; Luciferases; MHAM; MMAC1; MMAC1 protein; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Mesoinositol; Mice; Modeling; Monitor; Murine; Mus; Mutate; Mutation; Novolin R; Oncogenes; Oncogenesis; Oncogenic; PI-3 Kinase; PI-3K; PI3-Kinase; PIK3CA; PIK3CA gene; PKB protein; PTEN; PTEN gene; PTEN protein; PTEN1; Pathway interactions; Phenotype; Phosphatase and Tensin Homolog; Phosphatases; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinase, Catalytic Subunit Gene; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Precipitation; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Kinase B; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene, Transcription Factor; PtdIns; PtdIns 3-Kinase; Quelling; RAC-PK protein; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; RNAi vector; Reactive Site; Receptor Activation; Receptors, Somatomedin; Reporter; Research Personnel; Researchers; Role; Second Messenger Systems; Second Messengers; Second-Site Suppressor Genes; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Suppressor Genes; TKR1; TL2; TNFSF10; TNFSF10 gene; TRAIL; Targetings, Gene; Testing; Tissue Growth; Transcription; Transcription factor genes; Transcription, Genetic; Transforming Genes; Transgenic Model; Transphosphorylases; Tumor Cell; Tumor Cell Line; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Tumor-Derived; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Validation; Work; acinus; biological signal transduction; c-akt protein; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer cell; cancer progression; cultured cell line; diabetes; experiment; experimental research; experimental study; expression vector; fly; fruit fly; gene product; genome mutation; inositol 3-phosphate; insulin signaling; interest; malignancy; malignant breast neoplasm; mammary; matrigel; mouse model; mutated in multiple advanced cancers 1 protein; myoinositol 3-phosphate; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; ontogeny; overexpression; p110-Alpha Gene; pathway; phosphatase and tensin homologue on chromosome ten; programs; protein expression; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; research study; second messenger; siRNA; social role; tool; transcription factor; triphosphate; tripolyphosphate; tumor; tumor progression; tumor suppressor; tumorigenesis",PTEN Tumor Suppressor and Signal Transduction,,82783,TCB,Tumor Cell Biology Study Section,,10,241297,
7752523,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA082830-09,,NCI:1;,2010,NATIONAL CANCER INSTITUTE,,LUBBOCK,UNITED STATES,BIOCHEMISTRY,19,609980727,US,TX,794306271,TEXAS TECH UNIVERSITY HEALTH SCIS CENTER,"REYNOLDS, CHARLES PATRICK;",1889823;,5R01CA082830,09/01/1999,12/31/2011,"(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'[{..}]6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; 1,1-cyclobutanedicarboxylic acid platinum complex; 13 cis retinoate; 13-cRA; 13-cis-Retinoic Acid; 13-cis-Vitamin A Acid; 2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid; 4-(Bis(2-chloroethyl)amino)phenylalanine; 4-HC; 4-Hydroperoxycyclophosphamide; 4-[bis(2-chloroethyl)amino]-L-phenylalanine; 9-Dimethylaminomethyl-10-hydroxycamptothecin; 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin; 9-methoxy-N,N-dimethyl-5-nitropyrazolo(3,4,5-k)acridine-2(6H)-propanamine; ABMT; Alkylating Agents; Alkylators; Anoxia, Cellular; Antioxidants; Assay; Autologous Bone Marrow Transplant; Autologous Bone Marrow Transplantation; Autologous Marrow Transplantation; BSO; Bioassay; Biologic Assays; Biological Assay; Blood Precursor Cell; Bone Marrow; Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-; Buthionine Sulfoximine; CBDCA; CTX; CYCLO-cell; Carboplatin; Carboplatino; Carloxan; Cell Anoxia; Cell Death; Cell Hypoxia; Cell Line; Cell Lines, Strains; Cell-Death Protease; CellLine; Ciclofosfamida; Ciclofosfamide; Cicloxal; Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; Clafen; Claphene; Clinical Data; Clinical Trials; Clinical Trials Design; Clinical Trials, Phase I; Clinical Trials, Phase II; Clinical Trials, Unspecified; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytofluorometry, Flow; Cytophosphan; Cytophosphane; Cytoxan; DL-O-Sarcolysin; DNA Damage; DNA Injury; DNA Topoisomerase Inhibitors; Data; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Disease Progression; Disease-Free Survival; Dose; Drug Combinations; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug resistance; Drugs; EPEG; Early-Stage Clinical Trials; Endoxan; Endoxana; Enduxan; Enzymes; Eposide; Etoposide; Event-Free Survival; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fosfaseron; Frequencies (time pattern); Frequency; GCS Inhibitors; Gamma-Glutamylcysteine Synthetase Inhibitor; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genoxal; Genuxal; Glutathione; Glutathione Synthesis Inhibitors; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Hematopoietic stem cells; Hour; Hycamptamine; Hycamtamine; Hydroperoxycyclophosphamide; Hypoxia; Hypoxia, Cellular; Hypoxic; ICE-like protease; Infusion; Infusion procedures; Isotretinoin; Isotretinoinum; L-Buthionine sulfoximine; L-PAM; L-Phenylalanine mustard; L-Sarcolysin Phenylalanine mustard; L-Sarcolysine; Laboratories; Lastet; Lead; Ledoxina; Lytotoxicity; Marrow; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measures; Medication; Melphalan; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Microfluorometry, Flow; Mitoxan; Mother Cells; Multi-Drug Resistance; Multidrug Resistance; Mutation; Neoplasm Metastasis; Neosar; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Oxygen Deficiency; P53; Patients; Pb element; Peptides; Perfosfamide; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 1 Clinical Trials; Phase 2 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phase I/II Trial; Phase II Clinical Trials; Phenylalanine Mustard; Physiologic; Physiological; Play; Pre-Clinical Model; Preclinical Models; Procytox; Progenitor Cells; Progenitor Cells, Hematopoietic; Proteins; Protocol; Protocols documentation; Pyrazoloacridine; Recurrence; Recurrent; Relapse; Relative; Relative (related person); Research Design; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Reticuloendothelial System, Bone Marrow; Retinoicacid-13-cis; Role; S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine; S-(n-Butyl)homocysteine Sulfoximine; SCHED; Salvage Therapy; Salvage-Tx; Schedule; Secondary Neoplasm; Secondary Tumor; Sendoxan; Stem cells; Stream; Study Type; Syklofosfamid; TP53; TP53 gene; TRP53; Testing; Therapeutic; Time; Topoisomerase Inhibitors; Topotecan; Tumor Cell; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Tissue; Vepesid; Zytoxan; alanine nitrogen mustard; anti-oxidant; base; cancer metastasis; caspase; chemotherapy; cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide; cis-4-hydroperoxycyclophosphamide; cis-Diammine(cyclobutanedicarboxylato)platinum II; cis-Retinoic Acid; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); clinical investigation; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; cytotoxic; cytotoxicity; drug resistant; drug/agent; falls; flow cytophotometry; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; genome mutation; heavy metal Pb; heavy metal lead; high risk; improved; loss of function; melfalan; multi-drug resistant; multidrug resistant; necrocytosis; neoplastic; neoplastic cell; new approaches; novel approaches; novel strategies; novel strategy; overexpression; p-di(chloroethyl)amino-L-phenylalanine; phase 1 study; phase 1 trial; phase 2 study; phase 2 trial; phase I trial; phase II trial; phenylalanine nitrogen mustard; platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); pre-clinical; preclinical; preclinical study; protocol, phase I; protocol, phase II; resistance mechanism; resistance to Drug; resistant; resistant mechanism; resistant to Drug; response; sarcolysin; social role; study design; study, phase II; tumor",Enhancing Activity of Alkylating Agents in Neuroblastoma,,82830,CONC,Clinical Oncology Study Section,,9,1,
7767690,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA083049-11,,NCI:460628;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"CREWS, CRAIG M;",7097798;,5R01CA083049,07/09/1999,01/31/2014,"Abnormal coordination; Abscission; Address; Adverse effects; Agents, Cytostatic; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Animal Model; Animal Models and Related Studies; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Ataxia; Ataxy; B blood cells; B-Cells; B-Lymphocytes; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood - brain barrier anatomy; Blood Vessels; Blood-Brain Barrier; Brachydanio rerio; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Drug; Cancers; Cell Communication and Signaling; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Locomotion; Cell Migration; Cell Movement; Cell Polarity; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Migration; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clinical Trials; Clinical Trials, Unspecified; Co-ordination disorder; Collaborations; Coordination Disorder; Coordination Impairment; Cornea; Cytostatic Drugs; Cytostatics; Danio rerio; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Dyscoordination; Dyssynergia; Embryo; Embryonic; Endothelial Cells; Epoxides; Epoxy Compounds; Excision; Extirpation; Faculty; Generalized Growth; Genes; Genes, p53; Genomics; Germinal Center; Goals; Growth; Health; Hemato-Encephalic Barrier; In Vitro; Incoordination; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; L-Methionine; Laboratories; Lack of Coordination; Lead; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Medication; MetAP-2; Metallopeptidases; Metalloproteases; Metalloproteinases; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methionine; Methionine, L-Isomer; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Motility; Motility, Cellular; Murine; Mus; N-terminal; NH2-terminal; Neoplasm Metastasis; Neovascularization Inhibitors; Null Mouse; P53; Pathway interactions; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phenotype; Phosphorylation; Play; Proliferating; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Proteome; Regulation; Removal; Research; Resolution; Role; Screening procedure; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure of germinal center of lymph node; Surgical Removal; T-Cells; T-Lymphocyte; TNP-470; TNP-470 (Fumagillin); TNP470; TP53; TP53 gene; TRP53; Therapeutic; Thymus-Dependent Lymphocytes; Tissue Growth; Treatment Side Effects; Tube; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor-Specific Treatment Agents; Validation; Zebra Danio; Zebra Fish; Zebrafish; analog; angiogenesis; antiangiogenic; anticancer agent; anticancer drug; antitumor agent; arrestin 2; base; biological signal transduction; cancer metastasis; casein kinase; cell growth; cell motility; cell type; cellular polarity; chemical genetics; clinical investigation; corneal; design; designing; drug/agent; experience; fumagillin; gastrulation; gene product; heavy metal Pb; heavy metal lead; in vitro Assay; in vivo; inhibitor; inhibitor/antagonist; insight; loss of function; malignancy; metalloproteinase (general); methionine aminopeptidase 2; model organism; neoplasm/cancer; novel; ontogeny; pathway; pre-clinical; preclinical; public health relevance; resection; screening; screenings; side effect; small molecule; social role; therapeutic development; therapy adverse effect; thymus derived lymphocyte; treatment adverse effect; tumor; tumor growth; vascular",Role of MetAP-2 in Angiogenesis and Wnt Signaling," RELEVANCE Cancer continues to a major health concern in the U.S.. Since the number of new drugs approved each year continues to decline, it is important that we continue to pursue new lines of inquiry that could lead to novel anti-tumor pharmaceuticals. Our research explores new avenues of research that if successful would address this need for new anticancer drugs.",83049,DMP,Drug Discovery and Molecular Pharmacology Study Section,,11,460628,
7780371,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA084354-09,,NCI:316444;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","YANG, PING ;",1875070;,5R01CA084354,12/01/1999,01/31/2012,"(SP-4-2)-Diamminedichloroplatinum; 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; 2',2'-DFDC; 2',2'-difluoro-2'-deoxycytidine; 2',2'-difluorodeoxycytidine; 2'-deoxy-2'-difluorocytidine; 2'Deoxy-2',2'-Difluorocytidine; 2,2 difluorodexoycytidine; ABC29; ABCC; ABCC1; ABCC1 gene; AP Endonuclease Class I; AP Lyase; AP endonuclease, human; APE1; APEN; APEN protein, human; APEX Nuclease; APEX Nuclease (Multifunctional DNA Repair Enzyme); APEX nuclease (multifunctional DNA repair enzyme) 1, human; APEX nuclease, human; APEX-1 protein, human; APEX1; APEX1 protein, human; APX; Acute; Adverse effects; Adverse reactions; Algorithms; Anthelone U; Apurinic/Apyrimidinic (Abasic) Endonuclease; Apurinic/Apyrimidinic Exonuclease; Arts; Award; Biological; Body Tissues; Budgets; CDDP; COCA2; Cancer Patient; Cancer Prognosis; Cancer Radiotherapy; Cancer Treatment; Cancer of Lung; Carcinoma, Non-Small-Cell Lung; Cells; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical Management; Comorbidity; Complex; Cysplatyna; DDP; DFN7; DNA Repair Pathway; DNA strand break; Data; Deoxyribonuclease (Apurinic or Apyrimidinic); Development; Diagnosis; Dichlorodiammineplatinum; Difluorodeoxycytidine; Disease Progression; Doctor of Medicine; Doctor of Philosophy; Dose-Limiting; Drugs; EGF; Electromagnetic Radiation, Ionizing; Enrollment; Epidemiology; Epidemiology, Molecular; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Epithelial; Esophageal; Esophagitis; Evaluation; FAEES3; FCC2; FLR; Failure (biologic function); Fatty Acid Ethyl Ester Synthase III Gene; Forecast of outcome; Funding; GFAC; GS-X; GS-X pump; GST1; GST3; GST3 Gene; GSTM1; GSTM1 gene; GSTP1; GSTP1 gene; GSTPP; Gene variant; General Prognostic Factor; Genes; Genetic; Genetic Determinism; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genomics; Genotype; Glutathione; Glutathione S-Transferase M1 Gene; Glutathione S-Transferase Pi Gene; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Grant; Growth Agents; Growth Factor; Growth Factor Receptors; Growth Factors, Proteins; Growth Substances; HAP1; HAP1 DNA repair enzyme, human; HAP1 protein, human (nuclease); HNPCC; HNPCC2; Human; Human Urinary Gastric Inhibitor; Human, General; Individual Differences; Inflammatory Response; Injury; Investigation; Investigators; Ionizing radiation; Knowledge; Laboratories; Lead; Learning; Lesion; Literature; Lung; M.D.; MGC5172; MGMT; MGMT gene; MLH1; MLH1 gene; MMH Gene; MRP; MRP1; MUTM Gene; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Medication; Metabolic; Methylguanine-DNA Methyltransferase Gene; Modality; Modeling; Molecular Epidemiology; Molecular Marker of Prognosis; Multifunctional DNA Repair Enzyme; N-Glycosylase/DNA Lyase Gene; NHEJ; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Homologous End Joining; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Nonhomologous DNA End Joining; OGG1; OGG1 gene; OGH1 Gene; Oat Cell Carcinoma of Lung; Outcome; Oxidative Stress; POLB; POLB gene; Pathway interactions; Patients; Pb element; Peyrone's Chloride; Peyrone's Salt; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenetics; Phase; Platinum; Platinum Black; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Pneumonia; Pneumonitis; Polymorphism (Genetics); Polymorphism, Genetic; Process; Prognosis; Prognosis Marker; Prognostic Factor; Prognostic Marker; Prognostic/Survival Factor; Programs (PT); Programs [Publication Type]; Proteins; Proto-Oncogene, Growth Factor Receptor; Pt element; Pulmonary Cancer; Pulmonary Inflammation; Pulmonary malignant Neoplasm; REF-1; REF1; Radiation Ionizing Radiotherapy; Radiation therapy; Radiation-Ionizing Total; Radiotherapeutics; Radiotherapy; Reaction; Recurrence; Recurrent; Ref-1 protein, human; Reporting; Research; Research Personnel; Research Resources; Researchers; Resistance; Resources; Respiratory System, Lung; Role; Small Cell Lung Cancer; Small Cell Neuroendocrine Carcinoma of the Lung; Small cell carcinoma of lung; Staging; Statistical Methods; Study of epidemiology; System; System, LOINC Axis 4; Taxane Compound; Taxanes; Testing; Thoracic Diseases; Thoracic Disorder; Tissues; Treatment Side Effects; Treatment outcome; Update; Urogastrone; Variant; Variation; Variation (Genetics); XP, Group A; XP, Group A Gene; XP1; XP1 Gene; XPA; XPA Complementing Gene; XPA Correcting Gene; XPA gene; XPAC; XPAC Gene; Xeroderma Pigmentosum I Gene; Xeroderma Pigmentosum, Complementation Group A Gene; Yang; advanced disease; allelic variant; anticancer therapy; base; beta-Urogastrone; cancer radiation therapy; cancer therapy; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; cytokine; dFdC; dFdCyd; design; designing; disease characteristic; disease diagnosis; drug/agent; enroll; epidemiology study; failure; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gemcitabine; gene product; genetic determinant; glutathione S-conjugate export pump; glutathione peroxidase; hMLH1; heavy metal Pb; heavy metal lead; homologous recombination; human APEX1 protein; improved; inhibitor; inhibitor/antagonist; interest; irradiation; lung cancer; lung small cell carcinoma; meetings; member; nonsmall cell lung cancer; outcome forecast; pathway; polymorphism; programs; pulmonary; redox factor 1, human; ref1 protein, human; repair; repaired; resistant; response; side effect; social role; survivorship; taxane; therapy adverse effect; tool; treatment adverse effect; treatment planning; treatment response; tumor",Genetic Determinants of Lung Cancer Survival,,84354,ZRG1,Special Emphasis Panel,,9,316444,
7767766,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA085573-10,,NCI:364967;,2010,NATIONAL CANCER INSTITUTE,,BRONX,UNITED STATES,ANATOMY/CELL BIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"YE, BIHUI HILDA;",8141866;,5R01CA085573,05/01/2000,02/28/2011,"Address; Adhesions; Autoregulation; B blood cells; B lymphoma; B-Cell CLL/Lymphoma-6 Gene; B-Cell Chronic Lymphocytic Leukemia Associated Oncogene; B-Cell Lymphoma 6 Protein; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; B-cell CLL/Lymphoma-6; B-cell Leukemia 1; BCL; BCL1 Oncogene; BCL5; BCL5 protein; BCL6; BCL6 Protein; BCL6 gene; Binding Sites; Biological Function; Biological Models; Biological Process; Biology; Blood Plasma Cell; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Bypass; Cell Aging; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Senescence; Cellular Aging; Cellular Oncogene; Cellular Proliferation; Chromatin; Chromosomal dislocation; Chromosomal translocation; Collaborations; Combining Site; Complex; Cys-His2 Zinc Finger Transcription Factor; Cys-His2 Zinc Finger Transcription Factor Gene; DLBCL; Diffuse Large B-Cell Lymphoma; Diffuse non-Hodgkin's lymphoma, large cell; Exons; FLR; Failure (biologic function); Feedback; Forecast of outcome; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Germinal Center; Germinoblastoma; Grant; Growth; HDAC; HDAC Proteins; Histone Deacetylase; Homeostasis; Immune system; Knockout Mice; LAZ-3 Gene; LAZ-3 Protein; LAZ3; Learning; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Diffuse, Large Follicular Center-Cell; Lymphoma, Histiocytic, Diffuse; Lymphoma, Large Lymphoid, Diffuse; Lymphoma, Large-Cell, Diffuse; Lymphoma, Large-Cell, Diffuse, Undifferentiated; Lymphoma, Malignant; Lymphoma-Associated Zinc Finger Gene on Chromosome 3; Lymphomagenesis; Maps; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Model System; Modeling; Models, Biologic; Mutation; NuRD; NuRD complex; Null Mouse; POZ-zinc; Pathway interactions; Pattern; Phenotype; Physiological Homeostasis; Plasma Cells; Plasmacytes; Play; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proto-Oncogenes; RNA Expression; Reaction; Reactive Site; Recruitment Activity; Regulation; Reticulolymphosarcoma; Role; STAT3; STAT3 gene; Sarcoma, Germinoblastic; Senescence, Cellular; Senescence, Replicative; Signal Pathway; Staging; Structure; Structure of germinal center of lymph node; System; System, LOINC Axis 4; Targetings, Gene; Testing; Tissue Growth; Transcription; Transcription, Genetic; Transgenic Mice; Translocation, Genetic; Treatment outcome; Universities; Work; ZNF51; ZNF51 Gene; Zinc Finger Domain; Zinc Finger Motifs; Zinc Finger Protein 51; Zinc Finger Protein 51 Gene; Zinc Fingers; bcl-6 protein; body system, allergic/immunologic; c-ONC; cell type; chromosome dislocation; chromosome translocation; design; designing; experiment; experimental research; experimental study; failure; gene product; genome mutation; histone modification; in vivo; inhibitor; inhibitor/antagonist; interest; large cell Diffuse non-Hodgkin's lymphoma; macrophage; mutant; novel; ontogeny; organ system, allergic/immunologic; outcome forecast; pathway; plasma cell differentiation; plasmocyte; prognostic; proto-oncogene protein bcl-6; protooncogene; recruit; research study; response; social role; tumorigenic",Role of the BCL 6 Proto Oncogene in B Cell Lymphomas,,85573,CAMP,Cancer Molecular Pathobiology Study Section,,10,364967,
7740206,R01,CA,5,,01/05/2010,11/30/2010,,5R01CA085935-10,,NCI:263242;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,BIOLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"CABRAL, FERNANDO R;",1973007;,5R01CA085935,04/01/2000,11/30/2010,"Affect; Amino Acid Substitution; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antimitotic Agents; Antimitotic Drugs; Antimitotics; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Asotax; Assay; Bioassay; Biologic Assays; Biological Assay; Bristaxol; Cancer Drug; Cancers; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Colcemid; Colcemide; Correlative Study; Development; Diagnostic tests; Disease; Disorder; Drug effect disorder; Drug resistance; Drugs; Future; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Human; Human, General; Knowledge; Lap18 protein; Literature; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Measures; Medication; Micro-tubule; Microtubular Function Inhibitors; Microtubules; Mitosis Inhibitor Agents; Mitosis Inhibitor Drugs; Mitosis Inhibitors; Mitotic Inhibitor Agents; Mitotic Inhibitor Drugs; Mitotic Inhibitors; Molecular Biology, Mutagenesis; Multigene Family; Mutagenesis; Mutate; Mutation; Paclitaxel; Paclitaxel (Taxol); Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Praxel; Proteins; Refractory; Relapse; Reporting; Resistance; Role; Site; Structure; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Transfection; Tubulin; Tumor-Specific Treatment Agents; anticancer agent; anticancer drug; cultured cell line; design; designing; disease/disorder; drug action; drug resistant; drug/agent; effective therapy; gene product; genome mutation; insight; leukemia-associated phosphoprotein p18; malignancy; metablastin; mutant; neoplasm/cancer; novel; oncoprotein 18; overexpression; phosphoprotein p18; phosphoprotein p19; prosolin; prototype; resistance mechanism; resistance mutation; resistance to Drug; resistant; resistant mechanism; resistant to Drug; social role; stathmin; tumor",Tubulin Mutations and Paclitaxel Resistance,,85935,ZRG1,Special Emphasis Panel,,10,263242,
7771731,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA086072-08,,NCI:320588;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"PESTELL, RICHARD G;",1863450;,5R01CA086072,04/01/2000,02/28/2014,"17beta-Hydroxy-5alpha-Androstan-3-One; 5 alpha-Dihydrotestosterone; 5-alpha-DHT; Ablation; Acetylation; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-; Androstanolone; Athymic Nude Mouse; BCL1; Binding Sites; Biological Function; Biological Process; Body Tissues; CCND1; CCND1 Protein; CCND1 gene; Cancer Cell Growth; Cancer of Prostate; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Line, Tumor; Cell Signaling; Cellular Expansion; Cellular Growth; Cessation of life; Chemotherapy-Hormones/Steroids; Chromatin; Combining Site; Complex; Correlative Study; Cultured Tumor Cells; Cyclin D1; Cyclin D1 Gene; D11S287E; DHT; Death; Dihydrotestosterone; Embryo; Embryonic; Endocrine Gland Secretion; Engineering; Engineerings; Epithelial Cell Proliferation; Epithelial Cells; Epithelium; Figs; Figs - dietary; Forecast of outcome; Funding; G1/S-Specific Cyclin D1; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genes, Cyclin D1; Genes, PRAD1; Genes, Regulator; Genes, bcl-1; Genetic; Genetic Transcription; Genital System, Male, Prostate; Growth; Histone Acetylase; Histone Acetylation; Histones; Hormones; Human; Human Prostate; Human Prostate Gland; Human, General; Intermediary Metabolism; Intracellular Communication and Signaling; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Knockout Mice; Link; METBL; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metabolic Processes; Metabolism; Mice; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Mice, Transgenic; Modeling; Molecular; Murine; Mus; Neoplastic Cells, Cultured; Nuclear Receptors; Nude Mice; Null Mouse; Oncogenesis; Outcome; PC3 cell line; PRAD1; PRAD1 Protein; Pathway interactions; Patients; Perinatal; Phosphorylation; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Protein Phosphorylation; Proto-Oncogene Proteins c-bcl-1; RNA Expression; Reactive Site; Receptor Signaling; Recruitment Activity; Regulation; Regulator Genes; Repression; Research Specimen; Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specimen; Stanolone; Survival Rate; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic Androgen; Therapeutic Androstanolone; Therapeutic Hormone; Time; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Transgenic Mice; Tumor Cell Line; Tumor Cells, Cultured; U21B31; United States; bcl-1 Genes; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c jun; c-bcl-1 Proteins; c-jun Gene; cancer cell; cancer diagnosis; cancer progression; cell growth; cyclin D; dorsolateral prostatic basic protein; experiment; experimental research; experimental study; histone acetyltransferase; in vivo; male; malignancy; men; men's; neoplasm progression; neoplasm/cancer; neoplastic progression; new therapeutic target; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; outcome forecast; pathway; probasin; prostate cancer cell line; public health relevance; receptor expression; receptor function; recruit; regulatory gene; research study; resistant; response; social role; tissue culture; trans acting element; transcription factor; tumor progression; tumorigenesis",Androgen Receptor Function in Prostate Cancer," Project Narrative Significance. The mechanisms governing androgen ablation therapy resistance of prostate cancer involves hyperactivation of the AR. A subset of key genes correlate with prostate cancer outcome and/or have been shown to regulate AR activity in prostate cancer cells in tissue culture (Akt1, c-Jun, cyclin D1, Sirt1), however, the role of these key genes in regulating AR function in vivo is not known, therefore, we have generated genetic deletion models in the mouse. As our studies show acetylation of the AR governs the growth properties of the AR in human prostate cancer cells and the AR acetylation site is a key target through which these genes (Akt1, c-Jun, cyclin D1, Sirt1) regulate the AR, we have developed new prostate cancer cell lines to conduct mechanistic studies of the regulation of AR acetylation by these target genes.",86072,TCB,Tumor Cell Biology Study Section,,8,320588,
7776927,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA087658-10,,NCI:290327;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"ZHOU, MING-MING ;",2797459;,5R01CA087658,07/01/2000,02/28/2011,"3-D structure; 3-dimensional structure; 3D structure; Acetylation; Address; Amino Acids; Arginine; Arginine, L-Isomer; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Biological; Biology; Bromodomain; C4HC3 Zinc Finger; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chromatin; Chromosome Pairing; Combining Site; Complex; Consensus; Data; Disease; Disorder; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Gene Expression; Gene Inactivation; Gene Silencing; Gene Transcription; Genes; Genetic Transcription; Genetic Transduction; Genome; Genome, Human; Genomics; Goals; Hereditary; Histone Code; Histones; Human; Human Biology; Human Genome; Human, General; Inherited; Investigation; Investigators; Knowledge; L-Arginine; L-Lysine; Lead; Ligand Binding; Ligands; Link; Lysine; Man (Taxonomy); Man, Modern; Methods; Modeling; Modification; Molecular; Molecular Interaction; Nature; PHD Finger; PHD Finger Motif; Pattern; Pb element; Peptide Domain; Plant Homeodomain Type Zinc Finger; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Protein Domains; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA Expression; Reactive Site; Reading; Regulation; Research; Research Personnel; Researchers; Role; S cerevisiae; Saccharomyces cerevisiae; Site; Specific qualifier value; Specificity; Specified; Structure; Structure-Activity Relationship; Subcellular Process; Synapsis; Synapsis, Chromosomal; Tail; Tertiary Protein Structure; Testing; To specify; Transcription; Transcription, Genetic; Transduction, Genetic; Yeast, Baker's; Yeast, Brewer's; Yeasts; aminoacid; base; biological systems; chemical structure function; chromatin protein; combinatorial; disease/disorder; gene product; genome sequencing; genome-wide; heavy metal Pb; heavy metal lead; histone modification; new approaches; novel; novel approaches; novel strategies; novel strategy; protein complex; social role; structural biology; structure function relationship; three dimensional structure",Structure and Mechanism of Protein Module in Chromatin Biology,,87658,MSFB,Macromolecular Structure and Function B Study Section,,10,290327,
7761700,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA087879-10,,NCI:324371;,2010,NATIONAL CANCER INSTITUTE,,CHARLOTTESVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"STRIETER, ROBERT M;",1864183;,5R01CA087879,07/15/2000,01/31/2011,"4q Chemokine; Abscission; Adenocarcinoma, Renal Cell; Agonist; Angiogenesis Inhibition; Angiogenic Inhibition; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Biological; Biology; Body Tissues; C-X-C Chemokine Receptor Type 4; C-X-C Chemokines; CD183; CD184 Antigen; CDw128b; CDw128b Antigens; CKR-L2; CMKAR2; CMKAR3; CXC Chemokine Receptor 2; CXC Chemokines; CXC chemokine receptor 3; CXC-R4; CXCL12; CXCL12 gene; CXCR-4; CXCR2; CXCR2 Protein; CXCR3; CXCR3 gene; CXCR3 protein; CXCR3 receptor; CXCR4; CXCR4 Receptors; CXCR4 gene; Cancer Biology; Cancers; Carcinoma Cell; Carcinoma, Hypernephroid; Carcinoma, Non-Small-Cell Lung; Cell Death, Programmed; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cellular Immunity; Chemokine (C-X-C Motif) Receptor 4; Chemokine (C-X-C) Receptor 2; Chemokine, CXC Motif, Receptor 4; Co-Stimulator; Costimulator; D2S201E; Dose; Endothelial Cells; Endothelium; Epidermal Thymocyte Activating Factor; Excision; Extirpation; FB22; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Frequencies (time pattern); Frequency; Fusin; GPR9; GRO/MGSA Receptor; Generations; Genes; Grawitz Tumor; HM89; HSY3RR; High Affinity Interleukin 8 Receptor Type B; Human; Human, General; Hypernephroma; Hypoxia; Hypoxia Inducible Factor; Hypoxia-Inducible Factor Pathway; Hypoxia-Inducible Factor in the Cardiovascular System; Hypoxic; IFN; IL-2; IL-8RB; IL-8Rbeta; IL2; IL2 Protein; IL8 Receptor Type 2; IL8R2; IL8RB; IL8RB gene; IP10; IP10-R; ITX; Immunity; Immunity, Cellular; Immunologically Directed Therapy; Immunotherapy; Interferons; Interleukin 2; Interleukin 2 Precursor; Interleukin 8 Receptor Beta; Interleukin 8 Receptor Type 2; Interleukin II; Interleukin-2; Interleukin-8 Receptor Type B; Interleukin-8 Receptors B; Interleukin-8B Receptor; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Kinetic; Kinetics; L-leucyl-L-arginine; LAP3; LCR1; LESTR; LPS-Associated Protein 3; Leu-Arg; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Ligands; Link; Lipopolysaccharide-Associated Protein 3; Lymphocyte Mitogenic Factor; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Metastatic to; Mice; Mig-R; MigR; Mitogenic Factor; Modeling; Mononuclear; Murine; Mus; NPY3R; NPYR; NPYRL; NPYY3R; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Neoplasm Metastasis; Nephroid Carcinoma; Neuropeptide Y Receptor Y3; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Oncogenesis; Organ; Oxygen Deficiency; PBSF; PTK Receptors; Patients; Phenotype; Play; Post-Operative; Postoperative; Postoperative Period; Primary Neoplasm; Primary Tumor; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RAFT1 protein, human; RAPT1 protein, human; RTK; Rapamycin Target Protein; Receptor Activation; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Receptor, LESTR; Receptors, CXCR2; Removal; Renal Adenocarcinoma; Renal Cell Cancer; Renal Cell Carcinoma; Renal Cell Carcinoma, Stage Unspecified; Research Design; Research Specimen; Role; SCYB12; SDF-1 Receptor; SDF-1A; SDF-1B; SDF1; SDF1/PBSF Receptor CXCR4; SDF1A; SDF1B; Secondary Neoplasm; Secondary Tumor; Seven-Transmembrane-Segment Receptor, Spleen; Site; Solid Neoplasm; Solid Tumor; Specimen; Stromal Cell-Derived Factor 1 Receptor; Study Type; Surgical Removal; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; TLSF-A; TLSF-B; TPAR1; Testing; Thymocyte Stimulating Factor; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Tumor Antigens; Tumor Cell; Tumor Cell Migration; Tumor Immunity; Tumor-Associated Antigen; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; adenocarcinoma of kidney; alpha-Chemokines; angiogenesis; biomarker; cancer metastasis; cytokine; experiment; experimental research; experimental study; human FRAP1 protein; immune therapy; insight; leucyl-arginine; leucylarginine; mTOR; malignancy; model organism; neoplasm/cancer; neoplastic cell; nonsmall cell lung cancer; pre-clinical; preclinical; rapamycin and FKBP12 target 1 protein, human; receptor; research study; resection; response; social role; study design; trafficking; tumor; tumor growth; tumor-specific antigen; tumorigenesis",CXC Chemokines in Cancer,,87879,DT,Developmental Therapeutics Study Section,,10,324371,
7770818,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA087952-09,,NCI:234840;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"HOUGHTON, JANET ANNE;",1868044;,5R01CA087952,07/01/2000,01/31/2012,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-; 4-Sphingenine; APO2L; Alveolar; Alveolar Rhabdomyosarcoma; Antibodies; Apo-2L; Apopain; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); CAP4 protease; CASP-3; CASP3; CASP8 Protein; CDHS; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; CSBP1; CSBP2; CSPB1; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase-8/Flice; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; Cell-Death Protease; CellLine; Cells; Ceramide (lipids); Ceramides; Cessation of life; Characteristics; Childhood; Childhood Rhabdomyosarcoma; Clinical Research; Clinical Study; Complex; Cysteine Protease CPP32; DR5; DTP; Death; Developmental Therapeutics; Developmental Therapeutics Program; Developmental Therapy; Dihydrosphingosine; EXIP; Event; Extracellular Signal-Regulated Kinase Gene; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Forecast of outcome; Genes; Genome, Human; Goals; HUP2; Heterograft; Human Genome; ICE-like protease; Ink; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; KILLER; KILLER/DR5; Kynacyte; Ligands; MACH protein; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; Mammals, Mice; Mch5 protease; Mediating; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Molecular Interaction; Molecular Target; Murine; Mus; Mxi2; Nuclear Orphan Receptor; PARP Cleavage Protease; PAX3; PAX3 gene; PRKM14; PRKM15; PRKM8; Paired Box Gene 3; Paired Domain Gene HuP2; Patients; Pediatric Rhabdomyosarcoma; Phosphorylation; Prognosis; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Receptor Protein; Refractory; Regulation; Resistance; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Role; SAPK1; SAPK2A; SCA-1; SREBP Cleavage Activity 1; Science; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sphingolipids; Sphingosine; TL2; TNFRSF10B; TNFRSF10B gene; TNFSF10; TNFSF10 gene; TRAIL; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; Testing; Therapeutic; Transplantation, Heterologous; Treatment Efficacy; WS1; Xenograft; Xenograft procedure; Xenotransplantation; Yama; Yama protein; ZTNFR9; base; biological signal transduction; caspase; caspase-3; caspase-8; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytotoxic; effective therapy; fusion gene; gene product; inhibitor; inhibitor/antagonist; kinase inhibitor; necrocytosis; new therapeutics; next generation therapeutics; novel; novel therapeutics; outcome forecast; p38; p38 MAPK Gene; p38Alpha; pediatric; programs; receptor; resistant; social role; sphingosine 1-phosphate; sphingosine kinase; t(2;13)(q35;q14); therapeutic efficacy; therapeutic target; therapeutically effective; transcription factor",TRAIL Therapy for Rhabdomyosacrcoma,,87952,DT,Developmental Therapeutics Study Section,,9,234840,
7780333,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA088363-08,,NCI:190379;,2010,NATIONAL CANCER INSTITUTE,,HERSTON,AUSTRALIA,,,758815328,AS,,4029,QUEENSLAND INSTITUTE OF MEDICAL RESEARCH,"HAYWARD, NICHOLAS K;",6428595;,5R01CA088363,07/01/2000,01/31/2013,"0-11 years old; 15q; 21+ years old; ARF; Accounting; Active Follow-up; Adolescent; Adolescent Youth; Adult; Age; Alleles; Allelomorphs; Anatomic Sites; Articulation; CDK4I; CDKN2; CDKN2A; CDKN2A gene; CMM2; CNP; Causality; Child; Child Youth; Children (0-21); Chromosome 15 Distal Arm; Chromosome 15 Long Arm; Chromosome Arm; Chromosome Mapping; Chromosomes; Chronic; Copy Number Polymorphism; Cyclin-Dependent Kinase Inhibitor 2A Gene; DNA; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disorder; Environment; Environmental Factor; Environmental Risk Factor; Epistasis; Epistasis, Genetic; Epistatic Deviation; Etiology; Eye; Eye Color; Eyeball; Familial Melanoma; Family; Family member; France; Freckles; Functional RNA; Funding; GWAS; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Targeting; Gene variant; Genes; Genes, CDKN2; Genes, p16; Genes, p16INK4A; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Epistasis; Genetic Variation; Genetic defect; Genetics, Gene Mapping; Genetics, Other; Genome; Genotype; Grant; H2 gene; Hair; Hair Color; Haplotypes; Hereditary Melanoma; Host Factor; Host Factor Protein; Human; Human, Adult; Human, Child; Human, General; INK4; INK4A; Incidence; Individual; Integration Host Factors; Interaction Deviation; Intercistronic Region; Intervening Sequences; Introns; Joints; Life; Link; Linkage Mapping; London; MLM; MTS1; MTS1 Genes; Malignant Melanoma; Man (Taxonomy); Man, Modern; Maps; Measures; Mediating; Melanotic Nevus; Mole of Skin; Mole the mammal; Molecular Genetic; Molecular Genetics; Moles; Mutation; Netherlands; Nevi and Melanomas; Nevus; Non-Coding; Non-Coding RNA; Oligogenic Inheritances; Oligogenic Traits; Other Genetics; Pathway interactions; Phenotype; Pigmentation; Pigmentation physiologic function; Predisposition; Predisposition gene; Publishing; Queensland; Regions, Intergenic; Relative; Relative (related person); Research; Research Resources; Resources; Rest; Risk; Risk Factors; Sampling; Sampling Studies; Severities; Site; Skin; Societies; Specific qualifier value; Specified; Staging; Sun Exposure; Susceptibility; Susceptibility Gene; System; System, LOINC Axis 4; TP16; TSG9A; Targetings, Gene; Testing; The Sun; Time; Twin Multiple Birth; Twin Studies; Twins; United States; Update; Variant; Variation; Variation (Genetics); adult human (21+); allelic variant; burden of disease; burden of illness; case control; children; copy number variation; cost; density; disease burden; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environment effect on gene; environmental risk; follow-up; gene environment interaction; gene interaction; gene x gene interaction; genetic epidemiology; genetic epistases; genetic mapping; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; juvenile; juvenile human; melanoma; member; novel; older men; p14ARF; p16INK4 Genes; p16INK4a; pathway; population based; predisposing gene; proband; skin color; solar exposure; tumor; whole genome association studies; whole genome association study; years of life lost to disability; years of life lost to disease; youngster",Pathways from genotype and environment to melanoma,,88363,EPIC,Epidemiology of Cancer Study Section,,8,190379,
7758318,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA089113-08,,NCI:269442;,2010,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PATHOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"KIM, HYEONG-REH CHOI;",1892643;,5R01CA089113,12/01/2000,01/31/2013,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Acinus organ component; Adhesion Plaques; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Apoptotic; Binding; Binding (Molecular Function); Breast; C-terminal; Cancer Patient; Cancer Staging; Cancer of Breast; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell Surface Proteins; Cell Survival; Cell Viability; Cell physiology; Cell surface; Cell-Matrix Adherens Junctions; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Complex; Data; Development; Diagnostic Neoplasm Staging; Epithelial; Epithelial Cells; Extracellular Matrix, Integrins; FADK; FAK; FAK1; Focal Adhesions; Focal Contacts; Forecast of outcome; Funding; Goals; Human; Human, General; In Vitro; Integrins; Intracellular Communication and Signaling; Investigators; Light; MCF10A cells; MMP Inhibitor; MMPs; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Mediating; Mesenchymal; Metallopeptidases; Metalloproteases; Metalloproteinases; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular; Molecular Interaction; Morphogenesis; Neoplasm Metastasis; Neoplasm Staging; Non-Malignant; Oncogenic; Outcome; PHEMX; PHEMX Protein; PHEMX protein, human; PI-3 Kinase; PI-3K; PI3-Kinase; PTK2; PTK2 gene; Pan-Hematopoietic Expression Protein; Pathway interactions; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Photoradiation; Prognosis; Proteins, Cell Surface; PtdIns 3-Kinase; Regulation; Reporting; Research Personnel; Researchers; Role; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Staging; Subcellular Process; T-Stage; TIMP-1; TSSC6; TSSC6 protein, human; Testing; Tetraspanin; Time; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinases; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tumor Staging; Tumor stage; Tumor-Suppressing STF 6 Protein; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Up-Regulation; Up-Regulation (Physiology); Upregulation; abstracting; acinus; base; biological signal transduction; cancer metastasis; cancer progression; epithelial to mesenchymal transition; human PHEMX protein; in vivo; inhibitor; inhibitor/antagonist; malignant breast neoplasm; matrigel; member; metalloproteinase (general); model organism; neoplasm progression; neoplastic progression; new approaches; nonmalignant; novel; novel approaches; novel strategies; novel strategy; outcome forecast; overexpression; pan-hematopoietic expression protein, human; pathway; pp125FAK; social role; transcription factor; tumor progression; tumor suppressing subtransferable candidate 6 protein, human",A novel function of TIMP-1,,89113,TME,Tumor Microenvironment Study Section,,8,269442,
7756645,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA089225-08,,NCI:248900;,2010,NATIONAL CANCER INSTITUTE,,OMAHA,UNITED STATES,PHARMACOLOGY,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"KABANOV, ALEXANDER V;",1882376;,5R01CA089225,12/01/2000,01/31/2012,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 99mTc-Hexamibi; 99mTc-Sestamibi; ABCB1; ATP Dependent Proton Translocase; ATP phosphohydrolase; ATP phosphohydrolase (H+-transporting); ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; ATPase; Address; Adenocarcinoma of the Esophagus; Adenosine Triphosphatase; Adenosine Triphosphatase Complex; Adenosinetriphosphatase; Adriamycine; Affect; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Appearance; Asotax; Binding; Binding (Molecular Function); Blood Circulation; Bloodstream; Bristaxol; CAT Scan, Radionuclide; Cancer Drug; Cancer Treatment; Cancers; Cell Components; Cell Structure; Cells; Cellular Membrane; Cellular Structures; Chemosensitization; Chemosensitization/Potentiation; Chemotherapeutic Agents, Neoplastic Disease; Circulation; Clinical Trials, Phase II; Complex; Computerized Emission Tomography; DOX; Defense Mechanisms; Development; Doxorubicin; Doxorubicina; Drug Delivery; Drug Delivery Systems; Drug Efflux; Drug Formulations; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Drug resistance; Drugs; Emission-Computed Tomography; Endocytosis; Energy Expenditure; Energy Metabolism; Energy-Generating Resources; Esophageal Adenocarcinoma; Ethylene Oxide; F(0)F(1)-ATP Synthase; F(1)F(0)-ATPase; F0F1 ATPase; F1F0 ATPase Complex; FRET; Fluorescence Resonance Energy Transfer; Formulation; Formulations, Drug; Generalized Growth; Genes; Goals; Grant; Growth; H(+)-ATPase; H(+)-Transporting ATP Synthase; H(+)-Transporting ATPase; H(+)ATPase Complex; H+-Translocating ATPase; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; In Vitro; Intermediary Metabolism; Investigators; Knowledge; Label; Legal patent; Length; Lipid Rafts, Cell Membrane; MDR1 Protein; METBL; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Medication; Membrane; Membrane Microdomains; Membrane Potentials; Metabolic Processes; Metabolism; Mitochondria; Molecular Interaction; Monitor; Multi-Drug Resistance; Multidrug Resistance; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Outcome; Outcomes of Therapy; Oxides; Oxirane; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein Transporter; P-Glycoproteins; PGY-1 Protein; Paclitaxel; Paclitaxel (Taxol); Patents; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase 2 Clinical Trials; Phase II Clinical Trials; Photons; Pluronics; Polypropylenes; Potentiation; Praxel; Propene Polymers; Propylene Polymers; Proton-Translocating ATPase Complexes; Proton-Translocating ATPases; Research Personnel; Researchers; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Respiration; Respiratory Chain; Resting Potentials; Scintigraphy, Computed Tomographic; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Tc 99m Sestamibi; Tc MIBI; Tc-99m MIBI; Tc-99m-Methoxy-2-isobutylisonitrile; Tc99m Sestamibi; Technetium Tc 99m 2-Methoxy-2-methylpropylisonitrile; Technetium Tc 99m Sestamibi; Technetium(1+)-99Tc, hexakis(1-isocyano-2-methoxy-2-methylpropane)-, (OC-6-11)-; Technetium-99m-Hexamibi; Technetium-99m-Sestamibi; Therapeutic; Time; Tissue Growth; Tomography, Emission-Computed; Transmembrane Potentials; Tumor-Specific Treatment Agents; United States National Institutes of Health; anticancer agent; anticancer drug; anticancer therapy; cancer therapy; chemotherapeutic agent; chemotherapy; copolymer; cytotoxic; drug resistant; drug/agent; energy source; hydrogen transporting ATP synthase; improved; in vivo; inhibitor; inhibitor/antagonist; lipid raft; malignancy; membrane structure; mitochondrial; mitochondrial ATPase; multi-drug resistant; multidrug resistant; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; pathway; phase 2 study; phase 2 trial; phase II trial; poly(propylene oxide); prevent; preventing; protocol, phase II; psychological defense mechanism; radionuclide emission tomography; resistance to Drug; resistant; resistant to Drug; respiratory mechanism; response; small molecule; study, phase II; therapy outcome; tumor; uptake",Interactions of Pluronic block copolymers in drug resistant cancer,,89225,GDD,Gene and Drug Delivery Systems Study Section,,8,248900,
7753201,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA089655-08,,NCI:250486;,2010,NATIONAL CANCER INSTITUTE,,GAINESVILLE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"SIEMANN, DIETMAR W;",6278596;,5R01CA089655,12/01/2000,01/31/2013,"ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Advanced Cancer; Advanced Malignant Neoplasm; Affect; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Anti-Angiogenesis; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis; Antiangiogenesis Agents; Antiangiogenic Agents; Applications Grants; Blood Vessel Tumor; Blood Vessels; Bone Marrow Transplant; Bone Marrow Transplantation; COL18A1; Cancer Radiotherapy; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Signaling; Color; Combined Modality Therapy; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Effects of radiation; Endostatins; Endothelial Cells; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; FLR; Failure (biologic function); GFP; Goals; Grafting, Bone Marrow; Grant; Grant Proposals; Grants, Applications; Green Fluorescent Proteins; HEK3; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Ligands; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Manuscripts; Marrow Transplantation; Modality; Modeling; Mother Cells; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Muscle, Skeletal; Muscle, Voluntary; Neoplasms in Vascular Tissue; Neovascularization Inhibitors; Operation; Operative Procedures; Operative Surgical Procedures; PTK; Patients; Pb element; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; R Factors; R Plasmids; Radiation; Radiation therapy; Radiotherapeutics; Radiotherapy; Recombinant adeno-associated virus; Recombinant adeno-associated virus (rAAV); Research; Resistance Factors; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Solid Neoplasm; Solid Tumor; Stem cells; Surgical; Surgical Interventions; Surgical Procedure; Testing; Therapeutic; Treatment outcome; Tumor Angiogenesis; Tumor Cell; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; VEGFs; Vascular Endothelial Growth Factors; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Vegf; angiogenesis; antiangiogenesis therapy; antiangiogenic; anticancer therapy; biological signal transduction; blood vessel neoplasm; cancer progression; cancer therapy; chemotherapy; clinical practice; combination therapy; combined modality treatment; combined treatment; design; designing; effect, adverse, radiation; experiment; experimental research; experimental study; failure; gene product; heavy metal Pb; heavy metal lead; hydroxyaryl protein kinase; improved; insight; interventional strategy; irradiation; malignancy; multimodality therapy; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; neovasculature; new approaches; novel; novel approaches; novel strategies; novel strategy; programs; radiation effect; ray (radiation); research study; response; small molecule; social role; surgery; treatment response; treatment strategy; tumor; tumor progression; tyrosyl protein kinase; vascular",Combining Anti-Angiogenesis Strategies and Radiotherapy,,89655,RTB,Radiation Therapeutics and Biology Study Section,,8,250486,
7761289,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA090233-09,,NCI:363528;,2010,NATIONAL CANCER INSTITUTE,,PASADENA,UNITED STATES,NONE,29,009584210,US,CA,91125,CALIFORNIA INSTITUTE OF TECHNOLOGY,"ROTHENBERG, ELLEN V.;",1882488;,5R01CA090233,01/12/2001,01/31/2012,"Affect; Blood Precursor Cell; Cell Communication and Signaling; Cell Signaling; Cell division; Cells; Commit; DISSEC; Data; Defect; Dendritic Cells; Dissection; Elements; Gene Transcription; Genes; Genes, Regulator; Genetic; Genetic Transcription; Hematopoietic; Hematopoietic stem cells; In element; Indium; Intracellular Communication and Signaling; Link; Lymphoid; Maps; Mediating; Myelogenous; Myeloid; NF-JB protein; NFIL-1betaA protein; NFbetaA protein; Nature; Nucleic Acid Regulatory Sequences; Operation; Operative Procedures; Operative Surgical Procedures; PU.1 Gene; PU.1 Transcription Factor; Pathway interactions; Process; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Proteins; Pu-1 protein; RNA Expression; Regulator Genes; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Repression; Repressor Proteins; Reticuloendothelial System, Thymus; Role; SPI1; SPI1 Gene Product; SPI1 Protein; SPI1 gene; Signal Transduction; Signal Transduction Systems; Signaling; Silencer Elements; Silencer Elements, Transcriptional; Silencing Elements; Site; Spleen Focus Forming Virus Proviral Integration Gene 1; Staging; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; T-Cell Development; T-Cell Ontogeny; T-Cells; T-Lymphocyte; T-Lymphocyte Development; Thymic Lymphoma; Thymus; Thymus Gland; Thymus Lymphoma; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Transcriptional Silencer Elements; Veiled Cells; base; biological signal transduction; c-Spi-1 protein; developmental plasticity; gene product; genetic regulatory element; in vivo; insight; macrophage; notch; notch protein; notch receptors; novel; pathway; programs; proto-oncogene protein Spi-1; regulatory gene; social role; surgery; thymocyte; thymus derived lymphocyte; trans acting element; tumor",Lineage Commitment Mechanisms in Lymphoid Precursors,,90233,HP,Hematopoiesis Study Section,,9,363528,
7761311,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA090269-10,,NCI:317613;,2010,NATIONAL CANCER INSTITUTE,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"SHI, YIGONG ;",6193109;,5R01CA090269,03/01/2001,02/28/2011,"APO-1 Antigen; APO-1 Cell Surface Antigen; Adaptor Protein; Adaptor Signaling Protein; Apoptosis; Apoptosis Antigen 1; Apoptosis Pathway; Apoptotic; Applications Grants; Architecture; Autoimmune Diseases; Autoregulation; Biochemical; Biological Function; Biological Process; Biosynthetic Proteins; CAP4 protease; CASP8 Protein; CASP8 and FADD-like apoptosis regulating protein; CD95 Antigens; CD95 molecule; Cancers; Caspase-8/Flice; Casper protein; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cessation of life; Collaborations; Complex; Death; Death Domain; Development; Engineering / Architecture; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; FLICE-inhibitory protein; FLIP (cellular); Funding; Grant; Grant Proposals; Grants, Applications; Homeostasis; ICE-like protease; In Vitro; Intracellular Communication and Signaling; Length; MACH protein; Malignant Neoplasms; Malignant Tumor; Mch5 protease; Molecular; Organism; Pathway interactions; Pennsylvania; Physiological Homeostasis; Play; Process; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Recombinant Proteins; Resolution; Roentgen Rays; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; TNFRSF6 Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Universities; Work; X-Radiation; X-Rays; Xrays; Yang; autoimmune disorder; base; biological signal transduction; c-FLIP; caspase; caspase-8; cystein protease; cystein proteinase; cysteine endopeptidase; fas Antigens; fas Receptors; gene product; human disease; insight; living system; malignancy; necrocytosis; neoplasm/cancer; pathway; protein complex; reconstitute; reconstitution; social role",Structural Studies of Caspase Activation in Apoptosis,,90269,MSFB,Macromolecular Structure and Function B Study Section,,10,317613,
7759561,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA090351-10,,NCI:219973;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"XU, WENQING ;",8283965;,5R01CA090351,03/12/2001,01/31/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one; ARM Domain; ATRA; Accounting; All-trans retinoic acid; Armadillo Repeat; Armadillo/Beta-Catenin-Like Repeat; BCL9; BCL9 gene; Beta-Catenin Binding Repeat; Beta-Catenin-Binding Domain; Beta-Catenin-Like Repeat; Binding; Binding (Molecular Function); Binding Site Domain; Binding Sites; Biochemical; C-terminal; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancer Treatment; Cancers; Catenin, Beta-1; Cell Adhesion; Cell Communication and Signaling; Cell Signaling; Cellular Adhesion; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combining Site; Complex; Cytoplasmic Domain; Cytoplasmic Tail; Development; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Targeting; Drug Targetings; EC 2.7; Electrons; Embryo Development; Embryogenesis; Embryonic Development; Equilibrium; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Goals; Intracellular Communication and Signaling; Investigators; Kinases; LGS; Label; Lead; Length; Ligand Binding Domain; Macropain; Macroxyproteinase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Maps; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular Interaction; Multicatalytic Proteinase; N-terminal; NH2-terminal; Negative Beta Particle; Negatrons; Neoplasm Metastasis; Nuclear; Oncogenesis; Output; PRO2286; Pathway interactions; Pb element; Phosphorylation; Phosphotransferases; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Phosphorylation; Proteins; Proteosome; RNA Expression; Reactive Site; Receptor Protein; Regulation; Research Personnel; Researchers; Resolution; Retinoic Acid; Retinoic Acid Receptor; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic; Trans Vitamin A Acid; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transphosphorylases; Tretinoin; Tretinoinum; Tumor Cell Migration; Tumor Suppressor Proteins; Up-Regulation; Vitamin A Acid; Wnt proteins; Work; all-trans-Retinoic Acid; all-trans-Vitamin A acid; anticancer therapy; balance; balance function; base; base P; beta catenin; biological signal transduction; cancer metastasis; cancer therapy; design; designing; drug discovery; gene product; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; insight; malignancy; multicatalytic endopeptidase complex; neoplasm/cancer; pathway; prevent; preventing; programs; protein complex; protein function; protein protein interaction; receptor; scaffold; scaffolding; social role; trans-Retinoic Acid; tumor; tumor suppressor; tumorigenesis; ubiquitin ligase",Crystallographic Studies of the Wnt Signaling Pathway,,90351,MSFC,Macromolecular Structure and Function C Study Section,,10,219973,
7769856,R01,CA,5,,02/01/2010,01/31/2011,PA-03-145,5R01CA090464-08,,NCI:272340;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"CHANG, ERIC C;",1899526;,5R01CA090464,04/01/2001,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 26 S proteasome complex; 26S ATP-Dependent Protease; 26S ATP-Dependent Proteasome; 26S Proteasome Complex; 26S Proteosome; 26S protease; 26S proteasome; Acinus organ component; Actins; Allergy; Athymic Nude Mouse; Binding; Binding (Molecular Function); Binding Proteins; Biological; Biological Models; Bittner Virus; C-terminal; Cancer Treatment; Cancer of Breast; Cell Nucleus; Cell division; Cells; Cellular Matrix; Chromosome Segregation; Chromosomes; Complex; Cyclin B; Cytoskeletal System; Cytoskeleton; Data; Defect; Development; Duct; Duct (organ) structure; EAP1; EAP1 protein, human; ESP1-Associated Protein 1; Epithelial; Epithelial Cells; F-Actin; Family; Filamentous Actin; Fission Yeast; Fluorescence; Genes; Genetic; Genetic Models; Genetic Screening; Genome Instability; Genomic Instability; Genotoxins; Goals; Grant; Human; Human, General; Hypersensitivity; Intracellular Transport; Lead; Length; Ligand Binding Protein; Link; M Phase; M phase (cell cycle); MCF10A cells; MMTV; Macropain; Macroxyproteinase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer Virus; Mammary Glands, Human; Mammary Tumor Virus, Mouse; Mammary gland; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Mice, Athymic; Mice, Nude; Mitosis; Mitosis Stage; Mitotic; Model System; Models, Biologic; Models, Genetic; Molecular; Molecular Interaction; Mouse Mammary Tumor Virus; Multicatalytic Proteinase; Mutagens; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nucleus; Nude Mice; Oncogenesis; Ortholog; Orthologous Gene; P62 (cyclin B); PTTG protein, human; PTTG1; PTTG1 Gene Product; PTTG1 protein, human; Pb element; Photobleaching; Play; Polyubiquitin; Process; Prosome; Proteasome; Proteasome Binding; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Proteasome Interaction; Protein Binding; Protein Cleavage; Proteins; Proteolysis; Proteosome; Publishing; Recruitment Activity; Regulation; Regulatory Protein; Role; S pombe; Schizosaccharomyces pombe; Securin; System; System, LOINC Axis 4; TUTR1 protein, human; Testing; Transplantation; Transport Vesicles; Tumor Suppressor Proteins; Ubiquitin, poly-; United States National Institutes of Health; VESCL; Vesicle; Yeast Model System; Yeast, Fission; YeastModel; Yeasts; acinus; anaphase-promoting complex; anticancer therapy; breast tumorigenesis; cancer diagnosis; cancer therapy; cdc13 Protein; cell transformation; cyclosome; design; designing; gene function; gene product; genetic regulatory protein; genotoxic agent; hPTTG protein; hPTTG1 protein; heavy metal Pb; heavy metal lead; human PTTG1 protein; in vivo; intracellular skeleton; knock-down; malignant breast neoplasm; mammary; mammary tumor virus; milk agent; multicatalytic endopeptidase complex; mutant; overexpression; p56cdc13; pituitary tumor-transforming 1 protein, human; protein complex; recruit; regulatory gene product; securin, human; social role; transformed cells; transplant; tumor; tumor suppressor; tumorigenesis",REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY,,90464,ZRG1,Special Emphasis Panel,,8,272340,
7771758,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA090735-10,,NCI:300227;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,PATHOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"CLEARY, MICHAEL L;",1895574;,5R01CA090735,04/17/2001,02/28/2011,"21+ years old; Address; Adult; Affect; Amino Acids; Autoregulation; Award; B blood cells; B-Cells; B-Lymphocytes; Biology; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell physiology; Cells; Cellular Function; Cellular Oncogene; Cellular Physiology; Cellular Process; Cellular Proliferation; Chromosomal dislocation; Chromosomal translocation; Code; Coding System; Commit; Defect; Dependence; Development; Developmental Gene; Embryo; Embryonic; Essential Genes; Event; Gene Expression; Gene, Developmental; Generalized Growth; Generations; Genes; Genes, Essential; Genetic; Gestation; Growth; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoiesis; Hematopoietic; Hematopoietic Cancer; Hematopoietic Cellular Control Mechanisms; Homeo Domain; Homeo Domain Proteins; Homeobox Family Protein; Homeobox Proteins; Homeodomain Family Protein; Homeodomain Proteins; Homeoproteins; Homeostasis; Homeotic Proteins; Human, Adult; In Vitro; Investigators; Isoforms; Leukemia, Granulocytic; Malignant Hematologic Neoplasm; Mammals, Mice; Mice; Molecular; Mother Cells; Murine; Mus; Myelocytic Leukemia; Myelogenous Leukemia; Myeloid Leukemia; Neonatal; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Organ; Organ System; Orphan; Pathway interactions; Pattern; Physiological Homeostasis; Population; Population Process; Population-Level Process; Pregnancy; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Protein Family; Protein Isoforms; Proteins; Proto-Oncogenes; Regulatory Pathway; Research Personnel; Researchers; Resolution; Respiration; Role; Signal Pathway; Site; Staging; Stem cells; Subcellular Process; Time; Tissue Growth; Tissues; Translocation, Genetic; adult human (21+); aminoacid; body system; c-ONC; cell type; chromosome dislocation; chromosome translocation; gene product; homeodomain; in vivo; member; myeloid granulocytic leukemia; myelosis; null mutation; ontogeny; pathway; pediatric acute leukemia; progenitor; programs; protein complex; protein function; protooncogene; respiratory mechanism; self-renewal; social role; stem; transcription factor",Role of PBX Proteins in Hematopoiesis and Growth Control,,90735,HP,Hematopoiesis Study Section,,10,300227,
7755399,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA090853-09,,NCI:255009;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,OTHER BASIC SCIENCES,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"CLARET, FRANCOIS X;",6629534;,5R01CA090853,04/01/2001,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; APF-1; ATP-Dependent Proteolysis Factor 1; Activator Protein-1; Anchorage-Independent Growth; Anti-ERB-2; Anti-HER2/c-erbB2 Monoclonal Antibody; Anti-c-ERB-2; Anti-c-erbB2 Monoclonal Antibody; Anti-erbB-2; Anti-erbB2 Monoclonal Antibody; Anti-p185-HER2; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Binding Sites; Body Tissues; Breast Cancer Cell; Breast Cancer Model; Breast Cancer Treatment; Breast Carcinoma; Breast Neoplasms; Breast Tumors; C-EBP Nuclear Protein; C-EBP Proteins; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; CCND1 Protein; CDK Inhibitor Protein; CDK inhibitor p27; CDKI Protein; CDKN1B; CDKN1B protein; CDKN4 protein; CS5 protein, human; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cancers; Carcinoma Cell; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Cycle Control; Cell Cycle Genes; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Combining Site; Complex; Cyclin D1; Cyclin E; Cyclin Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; DNA; Data; Deoxyribonucleic Acid; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7; ERYF1; ERYF1 protein, human; EVI1; EVI1 gene; Ecotropic Viral Integration Site 1; Elements; Embryo; Embryonic; Enhancer-Binding Protein AP1; Erythroid Transcription Factor; Export, Nuclear; First Gap Phase; Forecast of outcome; Frequencies (time pattern); Frequency; Funding; Future; G1 Arrest; G1 Block; G1 Phase; G1 period; G1/S-Specific Cyclin D1; GATA Binding Protein 1; GATA binding protein 1, human; GATA-1; GATA1; GATA1 protein, human; GF1; GFP; Gap Phase 1; Gene Amplification; Gene Expression; Gene Transcription; Genentech brand of trastuzumab; Generalized Growth; Genes; Genes, Cell Division Cycle; Genes, cdc; Genes, p53; Genetic; Genetic Transcription; Goals; Grant; Green Fluorescent Proteins; Growth; HER2 Monoclonal Antibody; HMG-20; Herceptin; Heterograft; High Mobility Protein 20; Hoffman-La Roche brand of trastuzumab; Human; Human Breast Cancer Cell; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; JAB1 protein; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Jun activation domain-binding protein 1; Kinases; Kip1 protein; Knockout Mice; Knowledge; Laboratories; Lead; Linkage (Genetics); MDS1-EVI1; Macropain; Macroxyproteinase; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Carcinoma; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Mice, Knock-out; Mice, Knockout; MoAb HER2; Molecular; Molecular Interaction; Monitor; Multicatalytic Proteinase; Murine; Mus; NFE1; Nuclear Export; Nucleic Acid Regulatory Sequences; Nucleus; Null Mouse; Oncogenes; Oncogenesis; Oncogenic; Overexpression; P27KIP1; P53; PRAD1 Protein; PRDM3; Pathogenesis; Pathway interactions; Patients; Pb element; Phase; Phenotype; Phosphotransferases; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Binding; Protein Binding Domain; Protein Binding Motif; Protein Overexpression; Protein-Protein Interaction Domain; Proteosome; Proto-Oncogene Proteins c-bcl-1; RNA Expression; RNA, Small Interfering; Reactive Site; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research Personnel; Researchers; Resistance; Retroviral Vector; Retrovirus Vector; Roche brand of trastuzumab; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Solid Neoplasm; Solid Tumor; Specificity; TP53; TP53 gene; TRP53; Testing; Therapeutic; Time; Tissue Growth; Tissues; Trans-Activation (Genetics); Transactivation; Transcription; Transcription Activation; Transcription Factor AP-1; Transcription Factor GATA1; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Transforming Genes; Transphosphorylases; Transplantation, Heterologous; Trastuzumab; Tumor Cell; Tumor Protein p53 Gene; Tumor Volume; Tumorigenicity; Ubiquitin; Up-Regulation; Up-Regulation (Physiology); Upregulation; Volume, Tumor; Work; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; breast tumorigenesis; c jun; c-bcl-1 Proteins; c-erb-2 Monoclonal Antibody; c-jun Gene; c-jun Proto-Oncogene; cancer progression; cdc Genes; cell transformation; cyclin D; cyclin-dependent kinase inhibitor 1B; domain mapping; erythrold transcription factor 1; fluorescence imaging; genetic linkage; genetic regulatory element; globin transcription factor 1; globin transcription factor 1, human; heavy metal Pb; heavy metal lead; human GATA1 protein; in vivo; inhibitor; inhibitor/antagonist; insight; knock-down; malignancy; malignant breast neoplasm; mammary cancer model; mammary tumor; mammary tumor model; multicatalytic endopeptidase complex; mutant; natural gene amplification; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; ontogeny; outcome forecast; overexpress; overexpression; p27 Kip1 protein; p27 protein; p27(Kip); p27-Kip1; p27Kip1 protein; pathway; protective effect; resistant; rhuMAb HER2; sgn5 gene product; siRNA; signalosome subunit 5; social role; subcutaneous; therapeutic target; transcription factor; transformed cells; tumor; tumor growth; tumor progression; tumorigenesis",Targeting JAB1 Oncogenic Function in Breast Cancer,,90853,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,9,255009,
7758832,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA090877-08,,NCI:295173;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"ALEXANDER, CAROLINE MARGARET;",6630621;,5R01CA090877,04/01/2001,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; After Care; After-Treatment; Aftercare; Alleles; Allelomorphs; Assay; BRCA1; BRCA1 gene; Behavior; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Breast; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer Type 1 Susceptibility Gene; Breast Neoplasms; Breast Tissue; Breast Tumors; Cancer Causing Agents; Cancer Genes; Cancer Radiotherapy; Cancer stem cell; Cancer-Promoting Gene; Carcinogen exposure; Carcinogens; Cell Communication and Signaling; Cell Fraction; Cell Signaling; Cell surface; Data; Development; ERBB2; ERBB2 gene; Epithelial Cells; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Event; Fats; Fatty acid glycerol esters; Female Groups; Forecast of outcome; Genentech brand of trastuzumab; Generalized Growth; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Growth; HER -2; HER-2; HER2; HER2/neu; HSPG; Hematopoietic; Heparan Sulfate Proteoglycan; Herceptin; Hereditary Breast Cancer 1; Hoffman-La Roche brand of trastuzumab; Human EGF Receptor 2 Gene; Humulin R; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Literature; Liver; Lung; Mammals, Mice; Mammary Cancer; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Maps; Measures; Mice; Mice, Transgenic; Modeling; Molecular; Mother Cells; Mouse Strains; Murine; Mus; Mutate; Mutation; Neoplasms; Novolin R; Oncogenes; Oncogens; P53; PSCP; Pathogenesis; Pathway interactions; Process; Progenitor Cells; Prognosis; Property; Property, LOINC Axis 2; Proteoheparan Sulfate; RNF53; Radiation therapy; Radiotherapeutics; Radiotherapy; Recruitment Activity; Recurrence; Recurrent; Resistance; Respiratory System, Lung; Roche brand of trastuzumab; Role; SUBGP; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; Subgroup; TAM; TKR1; TP53; TP53 gene; TRP53; Tamoxifen; Testing; Tissue Growth; Tissues; Transforming Genes; Transgenic Mice; Transgenic Organisms; Tumor Burden; Tumor Load; Tumor Process; Tumor Protein p53 Gene; Tumor-Associated Process; Tumors; Women's Group; base; biological signal transduction; biomarker; body system, hepatic; brca 1 gene; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer initiation; chemical carcinogenesis; genome mutation; in vivo; irradiation; mammary; mammary tumor; mutant; neoplasia; neoplastic growth; ontogeny; organ system, hepatic; outcome forecast; pathway; precursor cell; prevent; preventing; progenitor; public health relevance; pulmonary; reconstitute; reconstitution; recruit; resistant; response; social role; stem; syndecan; tool; transgenic; triple-negative invasive breast carcinoma; tumor",The Role of Syndecan-1 in Mouse Mammary Neoplasia,,90877,MONC,Molecular Oncogenesis Study Section,,8,295173,
7760680,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA092423-09,,NCI:328058;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"RIGAS, BASIL ;",1947960;,5R01CA092423,07/01/2001,01/31/2012,"2-(Acetyloxy)benzoic Acid; Accounting; Acetylsalicylic Acid; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Aspergum; Aspirin; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; CSBP1; CSBP2; CSPB1; Cancer Cell Growth; Cancer Control; Cancer Control Science; Cancers; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Cycle Kinetics; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Kinetics; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Cessation of life; Chemicals; Chemoprevention; Chemopreventive; Chemopreventive Agent; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Cola; Colon; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Colorectal Cancer; Controlled Clinical Trials; Data; Death; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; EXIP; Ecotrin; Empirin; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Entericin; Extracellular Signal-Regulated Kinase Gene; Extren; Funding; Generalized Growth; Genus Cola; Goals; Growth; Human; Human, General; Individual; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; Kidney; Link; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; Malignant Cell; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Man (Taxonomy); Man, Modern; Measurin; Mediating; Medication; Mitogen-Activated Protein Kinase Gene; Mononitrogen Monoxide; Mxi2; N element; N2 element; Necrosis; Necrotic; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Oxygen; PRKM14; PRKM15; PRKM8; Pancreas Cancer; Pancreatic Cancer; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Placebo Control; Prevention; Prevention strategy; Preventive strategy; Production; SAPK1; SAPK2A; Seminal; Series; Side; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Time; Tissue Growth; Urinary System, Kidney; Western World; Work; anticarcinogenic; base; biological signal transduction; cancer cell; cancer prevention; cell growth; clinical investigation; clinical test; colon carcinogenesis; colophony; drug/agent; endothelial cell derived relaxing factor; gastrointestinal; malignancy; model organism; necrocytosis; neoplasm/cancer; ontogeny; p38; p38 MAPK Gene; p38Alpha; pathway; pre-clinical; preclinical; prevent; preventing; renal; research clinical testing; rosin",No-Releasing Aspirin and Colon Cancer Prevention,,92423,ZRG1,Special Emphasis Panel,,9,328058,
7796887,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA092479-08,,NCI:286606;,2010,NATIONAL CANCER INSTITUTE,,RALEIGH,UNITED STATES,GENETICS,04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"THREADGILL, DAVID W.;",1870456;,5R01CA092479,06/01/2001,01/31/2013,"Ablation; Accounting; Address; Alleles; Allelomorphs; Attenuated; Automobile Driving; Avian Erythroblastosis Virus Oncogene B; Biology; Cancer Treatment; Cancerous; Cancers; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chimp; Chimpanzee; Clinical Treatment; Colon; Colorectal Cancer; Colorectal Neoplasms; Data; Death; Development; Dose; Drivings, Automobile; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR gene; EGFR-TK Inhibitor; ERB-B; ERBB; ERBB Protein; ERBB1; ERBB1 Gene; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epithelial Cells; Erythroblast Transforming Gene B; Evaluation; Funding; Gene Expression; Gene Expression Profile; Genes; Genes, erbB; Glean; Grant; HER1; Hand; Human; Human, General; Intestinal; Intestines; Intracellular Communication and Signaling; Large Intestine Neoplasm; Large Intestine Tumor; Ligands; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Modeling; Molecular Target; Murine; Mus; Neoplasm of the Large Bowel; Oncogene ERB B; Oncogene, EGFR; Oncogenesis; Pan; Pan Genus; Pan Species; Pathway interactions; Patients; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Publications; Publishing; Reagent; Receptor Inhibition; Receptor Protein; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Resistance; Role; Scientific Publication; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Therapeutic; Transforming Growth Factor alpha Receptor; Tumor of the Large Bowel; Tumors, Colorectal; Work; anticancer therapy; base; biological signal transduction; biomarker; bowel; c-erbB-1; c-erbB-1 Protein; cancer diagnosis; cancer therapy; cell type; colorectal neoplasia; driving; erbB Genes; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene expression signature; improved; in vivo; inhibitor; inhibitor/antagonist; insight; malignancy; mouse model; neoplasm/cancer; new therapeutic target; novel; pathway; programs; proto-oncogene protein c-erbB-1; public health relevance; receptor; resistant; social role; therapeutic target; transcriptome; trial regimen; trial treatment; tumor; tumorigenesis",ERBB receptors in normal and cancerous colon biology,,92479,MONC,Molecular Oncogenesis Study Section,,8,286606,
7762227,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA092487-07,,NCI:314553;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,SURGERY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"FANG, BINGLIANG ;",1976035;,5R01CA092487,07/01/2001,01/31/2012,"Adenoviral Vector; Adenovirus Vector; Adverse effects; Animals; Apoptosis; Apoptosis Pathway; Bystander Effect; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Treatment; Cancer cell line; Cancers; Carcinoma, Non-Small-Cell Lung; Cell Death, Programmed; Cells; Clinical; Clinical Research; Clinical Study; Cytolysis; Fiber; Fibroblasts; Future; GFP; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Goals; Green Fluorescent Proteins; H1299; Hamsters, Golden; Hamsters, Syrian; Human; Human, General; Immune response; Immunocompetent; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; In Vitro; Individual; Induction of Apoptosis; Intervention, Genetic; Killings; Laboratories; Lead; Ligands; Lysis; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mesocricetus auratus; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Modeling; Molecular Biology, Gene Therapy; Murine; Mus; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Neoplasm Metastasis; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Normal Cell; Normal Tissue; Normal tissue morphology; Oncolytic; Oncolytic viruses; Pb element; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Resistance; Safety; Secondary Neoplasm; Secondary Tumor; Solid; Syrian Hamsters, Golden; System; System, LOINC Axis 4; TERT protein, human; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TP2 protein; Telomerase; Telomerase Reverse Transcriptase Protein; Telomere Reverse Transcriptase; Testing; Therapeutic; Therapeutic Agents; Therapy, DNA; Toxic effect; Toxicities; Treatment Side Effects; Tumor Cell; Tumor Cell Migration; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumor Tissue; Viral; adeno vector; adenovector; anticancer activity; anticancer therapy; base; cancer cell; cancer metastasis; cancer therapy; clinical applicability; clinical application; cytotoxic; gene therapy; genetic therapy; hEST2 protein; hTERT protein; hTRT protein; heavy metal Pb; heavy metal lead; host response; human TERT protein; immunoresponse; immunosuppressed patient; in vivo; malignancy; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; nonsmall cell lung cancer; novel therapeutics; oncolysis; oncolytic vector; pre-clinical; preclinical; preclinical study; resistant; side effect; subcutaneous; success; telomerase reverse transcriptase, human; therapy adverse effect; transduction efficiency; treatment adverse effect; treatment strategy; tumor; tumor necrosis factor (unspecified); tumor xenograft; vector",Oncolytic adenovector-mediated TRAIL gene therapy for cancers,,92487,DT,Developmental Therapeutics Study Section,,7,314553,
7760068,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA093237-09,,NCI:291081;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"DIEHL, J. ALAN;",6734686;,5R01CA093237,07/01/2001,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Alimentary Canal; Alleles; Allelomorphs; Apoptosis; Apoptosis Pathway; Autoregulation; B blood cells; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Bone Marrow Involvement; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CCND1 Protein; Cancerous; Cancers; Categories; Cell Communication and Signaling; Cell Cycle; Cell Cycle Progression; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cell Transformation, Neoplastic; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Chromosomal dislocation; Chromosomal translocation; Cyclin D1; Cyclins; Cytoplasm; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; Data; Development; Diagnosis; Digestive Tract; Disease; Disorder; Double Strand Break Repair; EC 2.7; Engineering; Engineerings; Export, Nuclear; F Box; F Box Domain; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; Forecast of outcome; Frequencies (time pattern); Frequency; G1/S-Specific Cyclin D1; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Generalized Growth; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genomic Instability; Germinoblastoma; Grant; Growth; HMG-20; High Mobility Protein 20; Homeostasis; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; Isoforms; Kinases; Laboratories; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Malignant; Lymphoma, Mantle-Cell; Lymphoma, Small-Cell, Centrocytic; Lymphomagenesis; Macropain; Macroxyproteinase; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse; Mammals, Mice; Man (Taxonomy); Man, Modern; Mantle-Zone Lymphoma; Mice; Mice, Transgenic; Molecular Interaction; Multicatalytic Proteinase; Murine; Mus; Mutation; Neoplasms; Neoplastic Cell Transformation; Normal Cell; Nuclear; Nuclear Export; Nucleus; Oncogenesis; Oncogenic; P53; PRAD1 Protein; Pathway interactions; Phase; Phenotype; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Pre-Replication Complex; Prognosis; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Cleavage; Protein Isoforms; Protein Phosphorylation; Proteolysis; Proteosome; Proto-Oncogene Proteins c-bcl-1; RNA Splicing; Refractory; Regulatory Pathway; Research; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Spleen; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Spleen; Splicing; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Transgenic Mice; Translocation, Genetic; Transphosphorylases; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Tumor-Derived; Tumors; Ubiquitilation; Ubiquitin; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; Ubiquitination; Ubiquitinoylation; Work; alimentary tract; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; cell growth; cell transformation; chromosome dislocation; chromosome translocation; cyclin D; digestive canal; disease/disorder; effective therapy; experiment; experimental research; experimental study; genome mutation; malignancy; mouse model; multicatalytic endopeptidase complex; mutant; neoplasia; neoplasm/cancer; neoplastic cell; neoplastic growth; neoplastic transformation; novel; ontogeny; outcome forecast; overexpression; pathway; pre-RC; programs; research study; social role; stem; transformed cells; tumor; tumorigenesis; tumorigenic; ubiquination; ubiquitin conjugation",Nuclear Accumulation of Cyclin D1 and Oncogenesis,,93237,ZRG1,Special Emphasis Panel,,9,291081,
7752825,R01,CA,5,,01/29/2010,11/30/2010,PA-07-070,5R01CA093626-07,,NCI:312504;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"KEALL, PAUL J;",6802723;,5R01CA093626,07/01/2001,11/30/2013,"4-dimensional; Address; Affect; Algorithms; Anatomic; Anatomical Sciences; Anatomy; Applications Grants; Artifacts; Aspiration, Respiratory; Biofeedback; Body Tissues; Breast; Breathing; Bronchial Lymphoma; Cancer Detection; Cancer Patient; Cancer Radiotherapy; Cancer of Lung; Collaborations; Collimation; Collimator; Complex; Controlled Clinical Trials; Conventional X-Ray; Data; Development; Devices; Diagnostic Radiology; Diagnostic radiologic examination; Dose; Early treatment; Esophagus; FLR; Failure (biologic function); Feedback; Four-dimensional; Freedom; Frequencies (time pattern); Frequency; Future; Gastrointestinal Tract, Esophagus; Genital System, Male, Prostate; Goals; Grant; Grant Proposals; Grants, Applications; Health; Human Prostate; Human Prostate Gland; IMRT; Image; Inhalation; Inhaling; Inspiration, Respiratory; Intensity Modulated RT; Intensity Modulated Radiation Therapy; Intensity-Modulated Radiotherapy; Interdisciplinary Research; Interdisciplinary Study; Investigation; Laboratories; Liberty; Linear Accelerator; Linear Accelerator Radiotherapy Systems; Link; Liver; Lung; Lung Lymphoma; Lung Neoplasms; Malignant Tumor of the Lung; Malignant neoplasm of lung; Maps; Measurable; Mechanics; Medical Imaging, Positron Emission Tomography; Medical Imaging, X-Ray; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; Morbidity; Morbidity - disease rate; Morphologic artifacts; Mortality; Mortality Vital Statistics; Motion; Multidisciplinary Collaboration; Multidisciplinary Research; Normal Tissue; Normal tissue morphology; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Outcome; PET; PET Scan; PET imaging; PET/CT; PET/CT scan; PETSCAN; PETT; Pancreas Neoplasms; Pancreatic Tumor; Patients; Performance; Phase II/III Trial; Planning Methodology; Planning Technic; Planning Techniques; Plant Leaves; Position; Positioning Attribute; Positron Emission Tomography Scan; Positron-Emission Tomography; Procedures; Process; Programs (PT); Programs [Publication Type]; Prostate; Prostate Gland; Prostatic Gland; Proton Magnetic Resonance Spectroscopic Imaging; Pulmonary Cancer; Pulmonary Lymphoma; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; Rad.-PET; Radiation; Radiation Oncology; Radiation therapy; Radiography; Radiology, Diagnostic X-Ray; Radiotherapeutics; Radiotherapy; Radiotherapy Systems, Linear Accelerator; Research; Residual; Residual state; Respiratory System, Lung; Roentgenography; Scheme; Science of Anatomy; Screening procedure; Series; Staging; Stream; Study, Interdisciplinary; Surgical; Surgical Interventions; Surgical Procedure; Survival Rate; System; System, LOINC Axis 4; Techniques; Technology; Testing; Time; Tissues; Toxic effect; Toxicities; Training; Treatment outcome; Tumor Tissue; Tumor of the Lung; Tumor of the Pancreas; Visual; Width; X-Ray Imaging; X-Ray, Diagnostic; anatomy; base; body system, hepatic; cost; design; designing; failure; imaging; imaging modality; improved; inspiration; interdisciplinary approach; irradiation; leaf; lung cancer; millimeter; multidisciplinary; musician; next generation; novel; optic imaging; optical imaging; organ system, hepatic; pancreatic neoplasm; programs; public health relevance; pulmonary; ray (radiation); respiratory; screening; screenings; stereoscopic; surgery; technology/technique; tool; treatment planning; trend; tumor",4D IMRT: Stereotactic body radiotherapy for lung cancer," Relevance Lung stereotactic body radiotherapy (SBRT) is an increasingly used treatment for early stage lung cancer due to promising local control and survival rates. However, morbidity, and in some cases mortality, result using current technology. This comprehensive, multidisciplinary research program will develop improved treatment planning, image guidance and treatment delivery methods to offer unprecedented radiation beam-tumor targeting. Consequently the amount of healthy tissue irradiated and associated treatment toxicity will be reduced, resulting in improved health of lung cancer patients.",93626,RTB,Radiation Therapeutics and Biology Study Section,,7,312504,
7761297,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA093665-09,,NCI:284630;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"ATTARDI, LAURA D;",1889040;,5R01CA093665,01/01/2002,01/31/2012,"Ablation; Accounting; Address; Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Affect; Affinity Chromatography; Agar; Anchoring Junction; Antioncogene Protein p53; Apoptotic; Binding; Binding (Molecular Function); Biological Models; Body Tissues; Cancer Induction; Cancer Staging; Cancers; Carcinoma; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell-Cell Adhesion; Cellular Tumor Antigen P53; Chromatography, Affinity; Co-Immunoprecipitations; Data; Desmosomes; Development; Diagnosis; Diagnostic Neoplasm Staging; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dsg1 antigen; Dysfunction; Epidermis; Epithelial; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Forecast of outcome; Functional disorder; Gene Targeting; Generalized Growth; Genes, p53; Genetics, Human; Growth; Head and Neck; Head and neck structure; Human; Human Genetics; Human, General; Immigrations; In Vitro; In-Migration; Investigators; Knockout Mice; Link; Macula Adherens; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Membrane Proteins; Membrane-Associated Proteins; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Knock-out; Mice, Knockout; Model System; Modeling; Models, Biologic; Molecular Interaction; Mouse Strains; Murine; Mus; Neoplasm Metastasis; Neoplasm Staging; Neoplasm Transplantation; Null Mouse; Oncogenesis; Oncoprotein p53; Organism; P53; PFAN protein; Papilloma; Pemphigus foliaceus antigen; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Physiopathology; Play; Prognosis; Program Development; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein TP53; Protein p53; Proteins; Regulation; Research Personnel; Researchers; Role; Secondary Neoplasm; Secondary Tumor; Series; Skin Tissue; Spot Desmosome; Squamous Cell Epithelioma; Squamous cell carcinoma; Staging; Stratified Epithelium; Surface Proteins; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Tissue Growth; Tissues; Tumor Cell Migration; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Staging; Tumor Suppressor Proteins; affinity purification; base; cancer metastasis; cancer progression; carcinogenesis; defined contribution; desmoglein 1; epithelial carcinoma; experiment; experimental research; experimental study; gene product; in vivo; insight; keratinocyte; living system; malignancy; migration; mouse model; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; ontogeny; outcome forecast; p53 Antigen; p53 Tumor Suppressor; pathophysiology; programs; protein protein interaction; research study; response; social role; tumor; tumor growth; tumor progression; tumor suppressor; tumor transplant; tumor transplantation; tumorigenesis; tumorigenic",Characterization of the p53 Apoptotic Target Gene Perp,,93665,TME,Tumor Microenvironment Study Section,,9,284630,
7749055,R01,CA,5,,01/20/2010,12/31/2010,PA-07-070,5R01CA094170-09,,NCI:272694;,2010,NATIONAL CANCER INSTITUTE,,IRVINE,UNITED STATES,BIOCHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"LEE, WEN-HWA ;",1865035;,5R01CA094170,01/18/2002,12/31/2012,"3-D; 3-Dimensional; Acinus organ component; Animal Welfare; Animals; BMP10; BMP10 gene; BRCA1; BRCA1 Mutation; BRCA1 gene; Basic Fibroblast Growth Factor Gene; Bibliography; Binding; Binding (Molecular Function); Biological; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer Cell; Breast Cancer Treatment; Breast Cancer Type 1 Susceptibility Gene; CC3; Cancer Cell Growth; Cancer of Breast; Cell Death; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell-Death Protease; Cellular Proliferation; Complex; Conditioned Culture Media; Conditioned Medium; Country; Culture Media, Conditioned; DNA; DNA Damage; DNA Injury; DNA Sequence; Deoxyribonucleic Acid; Diagnosis; Diagnostic; Ecological impact; Elements; Environment; Environmental Impact; Epithelial Cell Proliferation; Epithelial Cells; Equipment; Ethics Committees, Research; FGF2; FGF2 gene; FGFB; Fibroblast Growth Factor 2 Gene; Future; Gene Down-Regulation; Gene Expression; Gene Targeting; Genes; Genome Stability; Goals; HMG I-C Protein; HMGA2 Protein; HMGI-C; HMGI-C Protein; HTATIP2; HTATIP2 gene; Haploid; Haploidy; Hereditary Breast Cancer 1; High Mobility Group AT-Hook 2; High Mobility Group Protein HMGIC Breakpoint Associated with Benign Lipoma; High Mobility Group Protein Isoform I-C; High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C; High-Mobility Group Protein HMGI-C; Human Breast Cancer Cell; IACUC; ICE-like protease; IL-17E; IRBs; Impact, Environmental; Impairment; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Killings; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Glands, Human; Mammary gland; Mediating; Molecular; Molecular Interaction; Mutation of the BRCA1 Gene; Nature; Nuclear; Oncogenesis; Oncogenic; PSCP; Pathogenesis; Pathway interactions; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RNF53; Repression; Research; Research Ethics Committees; Research Resources; Resources; Role; Sequence-Specific Posttranscriptional Gene Silencing; Stability, Genomic; TIP30; Targetings, Gene; Testing; Toxic effect; Toxicities; Trans-Activation (Genetics); Transactivation; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Corepressor; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Tumor Suppressor Proteins; Tumorigenicity; Up-Regulation; Vertebrate Animals; Vertebrates; abstracting; acinus; base; brca 1 gene; breast tumorigenesis; caspase; cell killing; cystein protease; cystein proteinase; cysteine endopeptidase; expiration; gene product; gene repression; human subject; in vivo; interleukin-17E; malignant breast neoplasm; mammary; mimicry; necrocytosis; novel; pathway; prognostic; programs; repair; repaired; response; social role; tumor; tumor suppressor; tumorigenesis; vertebrata",Transcriptional Role of BRCA1 in Breast Cancer,,94170,TCB,Tumor Cell Biology Study Section,,9,272694,
7760643,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA094194-08,,NCI:387333;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"BRODEUR, GARRETT M;",1894332;,5R01CA094194,01/14/2002,01/31/2013,"0-11 years old; 21+ years old; Adult; Animal Model; Animal Models and Related Studies; Autocrine Systems; BDNF; BDNF Receptor; BDNF/NT-3 Growth Factors Receptor; Behavior; Biological; Biological Function; Biological Process; Biotechnology; Brain-Derived Neurotrophic Factor; Breast; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Child; Child Youth; Childhood; Childhood Cancers; Children (0-21); Clinical; Clinical Trials; Clinical Trials, Unspecified; Critical Paths; Critical Pathways; Cytotoxic agent; Cytotoxic drug; Data; Differentiation and Growth; Dose; Engineering; Engineerings; Exposure to; Extracellular Signal-Regulated Kinase Gene; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family; Future; GP145-TRKB; Gene Expression; Gene Family; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Male, Prostate; Heterograft; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, Child; Human, General; In Vitro; Intracellular Communication and Signaling; Lead; Ligand Binding; Ligands; MAP Kinase Gene; MAPK; MGC34632; MYCN; MYCN gene; Malignant Childhood Neoplasm; Malignant Childhood Tumor; Malignant Pediatric Neoplasm; Malignant Pediatric Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Murine; Mus; Mutation; NMYC; NMYC Gene; NTRK2; NTRK2 Receptor; Nephroblastoma; Nerve Growth Factor Receptors; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurotrophic Factor Receptor; Neurotrophic Factor, Brain-Derived, Receptor; Neurotrophic Tyrosine Kinase Receptor Type 2; Outcome; PI-3K/AKT; PI3K/AKT; PTK Inhibitors; Pathway interactions; Patients; Pattern; Pb element; Phosphorylation; Phosphorylation Site; Play; Predictive Value; Prostate; Prostate Gland; Prostatic Gland; Protein Phosphorylation; Protein Tyrosine Kinase Inhibitors; Proteins; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Receptor Protein; Receptor, trkB; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Relapse; Renal Wilms' Tumor; Risk; Role; SCHED; Sampling; Schedule; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solid Neoplasm; Solid Tumor; Structure; TK Inhibitors; TRKB; TRKB Tyrosine Kinase; Therapeutic Index; Transgenic Mice; Transplantation, Heterologous; Tumorigenicity; Tyrosine Kinase Inhibitor; Wilm's Tumor; Wilms Tumor; Wilms' Tumor of the Kidney; Xenograft; Xenograft procedure; Xenotransplantation; adult human (21+); autocrine; behavior test; behavioral test; biological signal transduction; children; clinical investigation; cultured cell line; deletion analysis; gene induction; gene product; genome mutation; heavy metal Pb; heavy metal lead; high risk; human FRAP1 protein; in vivo; inhibitor; inhibitor/antagonist; insight; mTOR; medulloblastoma; model organism; novel; paracrine; pathway; patient population; pediatric; pediatric cancer; pediatric neoplasm/cancer; protein structure; public health relevance; rapamycin and FKBP12 target 1 protein, human; receptor; receptor expression; receptor structure function; response; social role; trkB(gp145) Protein; tumor; youngster",Trk Expression and Inhibition in Human Neuroblastomas,,94194,CAMP,Cancer Molecular Pathobiology Study Section,,8,387333,
7762184,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA094858-08,,NCI:230554;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,PATHOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"ABDULKADIR, SARKI A.;",2568412;,5R01CA094858,07/01/2002,01/31/2013,"Alleles; Allelomorphs; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Animals; Anti-Oncogenes; Antioncogenes; Antioxidants; Apoptosis; Apoptosis Pathway; Archives; Assay; Bioassay; Biologic Assays; Biological Assay; CCND1 Protein; CHIP assay; Cancer of Prostate; Cell Communication and Signaling; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; ChIP (chromatin immunoprecipitation); Chromatin; Cyclin D1; DNA Alteration; DNA mutation; Defect; Detection; Diagnosis; Dysplasia; EC 2.7.1.1; Emerogenes; Enzymes; Epithelial; Epithelial Cells; Expression Profiling; Expression Signature; FAD-dependent sulfhydryl oxidase; G1/S-Specific Cyclin D1; Gene Alteration; Gene Copy Number; Gene Dosage; Gene Expression; Gene Mutation; Gene Targeting; Genes; Genes, Cancer Suppressor; Genes, LacZ; Genes, Onco-Suppressor; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genital System, Male, Prostate; Glutathione[{..}]hydrogen-peroxide oxidoreductase; HK II; HK2 Protein; Hereditary; Hexokinase 2; Hexokinase II; Hexokinase, Type II; Hexokinase-2, Muscle; Histone Acetylation; Homeo Domain; Human; Human Prostate; Human Prostate Gland; Human, General; Hyperplasia; Hyperplastic; INFLM; Immunologic, Luciferase; In Vitro; Individual; Inflammation; Inherited; Intracellular Communication and Signaling; Kinetic; Kinetics; LacZ; LacZ Genes; Lead; Lectin; Light; Luciferases; Lymphocytes, Null; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Math Models; Mice; Mice, Mutant Strains; Modeling; Molecular Fingerprinting; Molecular Profiling; Molecular Target; Murine; Mus; Muscle Form Hexokinase; Mutant Strains Mice; Mutation; Null Cells; Null Lymphocytes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P53; PRAD1 Protein; Pattern; Pb element; Photoradiation; Pre-Clinical Model; Preclinical Models; Prevention; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic; Prostatic Cancer; Prostatic Gland; Prostatic Intraepithelial Neoplasia of the Prostate Gland; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasms; Prostatic Neoplasia; Prostatic Neoplasms; Prostatic intraepithelial neoplasia; Proteins; Proto-Oncogene Proteins c-bcl-1; Regulation; Reporter; Role; SOx enzyme; Sampling; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Therapeutic Androgen; Tissue Sample; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Genes; Tumor of the Prostate; Tumorigenicity; angiogenesis; anti-oxidant; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; chromatin immunoprecipitation; chromatin remodeling; cyclin D; dosage; dyscrasia; experiment; experimental research; experimental study; falls; gene function; gene product; genome mutation; genome-wide; glutathione peroxidase; heavy metal Pb; heavy metal lead; homeodomain; in vivo; insight; mathematical model; mathematical modeling; molecuar profile; molecular signature; mouse mutant; mutant; oncosuppressor gene; overexpression; oxidative DNA damage; oxidative damage; peroxiredoxin; programs; prostate intraepithelial neoplasm; protein expression; research study; response; social role; sulfhydryl oxidase; sulphydryloxidase; transcription factor; tumor initiation; tumorigenesis",Modeling Prostate Tumorigenesis,,94858,CG,Cancer Genetics Study Section,,8,230554,
7783851,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA094900-10,,NCI:267850;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,PATHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GONIAS, STEVEN L.;",1873369;,5R01CA094900,04/01/2002,02/28/2012,"1-Phosphatidylinositol 3-Kinase; ASV; ASVSRC1; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Adopted; Affinity; Agonist; Animal Model; Animal Models and Related Studies; Animals; Anthelone U; Arm; Atamir; Autocrine Systems; Basement membrane; Binding; Binding (Molecular Function); Biological; Biological Models; Body Tissues; Breast Cancer Cell; Breast Carcinoma; CAM 120/80; Cadherin-1; Cancer of Breast; Cancers; Carcinoma Cell; Cell Adhesion; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; Cell surface; Cells; Cellular Adhesion; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Migration; Cellular Physiology; Cellular Process; Closure by Ligation; Complement S-Protein; Complex; Cuprenil; Cuprimine; Cupripen; Cytoplasmic Membrane; Data; Defect; Depen; Development; Distamine; E-Cadherin; EC 3.4.21.7; EGF; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERK MAP Kinases; Enzyme Precursors; Enzymes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epibolin; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial Cells; Epithelial-Cadherin; Esteroproteases; Event; Extracellular Matrix Proteins; Extracellular Matrix, Integrins; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Feedback; Fibrinolysin; Fibroblasts; Foundations; G Protein-Complex Receptor; G-Protein-Coupled Receptors; GFAC; Gene Transcription; Genes; Genes, c-src; Genetic Transcription; Glu-Plasmin; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HEK3; Heterograft; Human Breast Cancer Cell; Human Urinary Gastric Inhibitor; Infection; Inflammatory; Integrins; Intracellular Communication and Signaling; Investigators; Kelatin; Knockout Mice; Learning; Ligands; Ligation; Link; Location; MTGN; Macromolecular Protein Complexes; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Carcinoma; Membrane; Membrane Proteins; Membrane-Associated Proteins; Mercaptyl; Mesenchymal; Metalcaptase; Metallopeptidases; Metalloproteases; Metalloproteinases; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Knock-out; Mice, Knockout; Mitogens; Model System; Modeling; Models, Biologic; Molecular Interaction; Morphology; Motility; Motility, Cellular; Multiprotein Complexes; Murine; Mus; Nature; Neoplasm Metastasis; Neoplasms; Non-Malignant; Null Mouse; PDGF; PI-3 Kinase; PI-3K; PI3-Kinase; PLAU; PTK; PTK Receptors; Pathway interactions; Pendramine; Peptidases; Peptide Hydrolases; Perdolat; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Plasma Membrane; Plasmin; Plasminogen; Plasminogen Activator; Plasminogen Activator, Urokinase; Platelet-Derived Growth Factor; Process; Proenzymes; Profibrinolysin; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protease F; Proteases; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteinases; Proteins; Proteolytic Enzymes; PtdIns 3-Kinase; R01 Mechanism; R01 Program; RNA Expression; RPG; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Recruitment Activity; Regulation; Reporting; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rho-associated kinase; Rho-kinase; Role; SRC; SRC gene; SRC1; Secondary Neoplasm; Secondary Tumor; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Serum Spreading Factor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Subcellular Process; Sufortan; Surface Proteins; System; System, LOINC Axis 4; Testing; Therapeutic; Threonine/Tyrosine Protein Kinase; Tissues; Transcription; Transcription, Genetic; Transmembrane Receptor Protein Tyrosine Kinase; Transplantation, Heterologous; Trolovol; Tumor Cell Migration; Tumors; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; U-PA; U-PA receptor; U-Plasminogen Activator; UPA; Upper arm; Urinary Plasminogen Activator; Urogastrone; Urokinase; Urokinase Plasminogen Activator Receptor; Urokinase Receptor; Urokinase-Type Plasminogen Activator; Urokinase-type Plasminogen Activator Receptor; Uvomorulin; VTN; Vimentin; Vitronectin; Work; Xenograft; Xenograft procedure; Xenotransplantation; Zymogens; autocrine; base; beta-Urogastrone; biological signal transduction; c src; c-src Proto-Oncogenes; cancer cell; cancer metastasis; cancer progression; cell growth; cell motility; cell type; design; designing; experiment; experimental research; experimental study; extracellular; extracellular signal related kinase; gene product; hydroxyaryl protein kinase; in vivo; malignancy; malignant breast neoplasm; member; membrane structure; metalloproteinase (general); migration; model organism; mouse model; neoplasia; neoplasm progression; neoplasm/cancer; neoplastic growth; neoplastic progression; nonmalignant; novel; pathway; plasmalemma; programs; receptor; receptor, pro-urokinase; recruit; research study; response; social role; tumor; tumor progression; tyrosyl protein kinase; uPAR receptor; v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog",Urokinase Receptor-initiated Cell-signaling,,94900,HT,Hemostasis and Thrombosis Study Section,,10,267850,
7754656,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA094994-08,,NCI:240825;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"HNATOWICH, DONALD J;",1898658;,5R01CA094994,03/01/2002,01/31/2012,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; Affinity; Animals; Anti-CEA Antibody; Antibodies; Antibodies, Bispecific; Base Sequence; Behavior; Bifunctional Antibodies; Binding; Binding (Molecular Function); Biotin; Bispecific Antibodies; CC49; CC49 antibody; Cancer Patient; Cancer Radiotherapy; Cancer of Breast; Cells; Dendrimers; Dendritic Compounds; Dendrons; Detection; Development; Dextrans; Diagnostic; Drug Kinetics; Fluorescence; Funding; Goals; In Vitro; Institution; Investigation; Knowledge; L-Lysine, homopolymer; Label; Laboratories; MAb CC49; MOAB CC-49/TAG72 (Centocor); MOAB CC-49/TAG72 (DW); Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Measurement; Methods; Mice; MoAb CC49; Modeling; Models, Molecular; Molecular; Molecular Interaction; Molecular Models; Molecular Target; Monoclonal Antibody CC-49; Monoclonal Antibody CC49; Murine; Mus; Normal Tissue; Normal tissue morphology; Nucleic Acid Biochemistry, Molecular Modeling; Nucleotide Sequence; Optics; Patients; Penetration; Pharmacokinetics; Phase; Polylysine; Polymers; Preparation; Printing; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Publications; Radiation; Radiation therapy; Radioactivity; Radioimmunoconjugate; Radiolabeled; Radiolabeled Antibodies; Radiopharmaceutical Compound; Radiopharmaceuticals; Radiotherapeutics; Radiotherapy; Scheme; Scientific Publication; Source; Strepavidin; Streptavidin; Surface Plasmon Resonance; System; System, LOINC Axis 4; Tag; Testing; Time; Tracer; Vitamin H; antibody conjugate; aqueous; bsAb; cancer diagnosis; coenzyme R; design; designing; dextran; divinyl ether; divinyl oxide; dosage; experience; fluorophore; imaging modality; improved; in vivo; interest; irradiation; maleic acid; malignant breast neoplasm; microautoradiography; molecular modeling; mouse model; multidisciplinary; new approaches; novel approaches; novel strategies; novel strategy; nucleic acid sequence; pre-clinical; preclinical; radioactive drugs; radiolabel; radiotracer; ray (radiation); success; tumor; vinyl ether",Improved Tumor Radiotherapy by MORF Pretargeting,,94994,RTB,Radiation Therapeutics and Biology Study Section,,8,240825,
7741194,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095099-07,,NCI:303461;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"SMITH, SUSAN ;",6872148;,5R01CA095099,04/01/2002,01/31/2014,"ADP-Ribosyltransferase (Polymerizing); Address; Age; Aging; Antibodies; Binding; Binding (Molecular Function); Biochemical; Biological; CPAP; CPAP Ventilation; Cancers; Cell Cycle; Cell Cycle Arrest; Cell Cycle Progression; Cell Division Cycle; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromosomes; Clinical; Continuous Positive Airway Pressure; DNA Binding; DNA Binding Interaction; DNA Replication; DNA Synthesis; DNA biosynthesis; Dysfunction; Elongation by Telomerase; Embryo; Embryonic; Fibroblasts; Functional disorder; G1 Arrest; G1 Block; G2 Phase; G2 period; Gap Phase 2; GeneHomolog; Genetic; Hand; HeLa; Hela Cells; Homolog; Homologous Gene; Homologue; Human; Human, General; Knockout Mice; Length; M Phase; M phase (cell cycle); Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mice; Mice, Knock-out; Mice, Knockout; Mitosis; Mitosis Stage; Mitotic; Molecular; Molecular Interaction; Murine; Mus; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; Nature; Null Mouse; PARP Homolog; PARP Polymerase; PARS; PIN2; Pathway interactions; Phosphorylation; Phosphorylation Site; Physiopathology; Play; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Process; Protein Phosphorylation; Proteins; Regulation; Role; SIS; Second Gap Phase; Senescence; Sister; Sister Chromatid; Structure; TERF1; TERF1 gene; TNKS; TRBF1; TRF1; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase; Tankyrase; Telomeric Poly-(ADP-Ribose)-Polymerase; Tumor Cell; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Work; base; cancer cell; cell type; cohesion; cultured cell line; experiment; experimental research; experimental study; gene product; hTRF1-AS; inhibitor; inhibitor/antagonist; insight; malignancy; neoplasm/cancer; neoplastic cell; overexpression; pathophysiology; pathway; poly ADP polymerase; poly ADP ribose synthetase; protein complex; public health relevance; research study; response; senescence; senescent; small molecule; social role; telomere; ubiquination; ubiquitin conjugation",Mechanisms of Telomere Function, Project Narrative (Relevance)  Telomeres (the ends of chromosomes) play a central role in aging and cancer. Understanding the proteins (such as tankyrase 1 and 2) that regulate telomere function in normal human cells and cancer cells will provide a framework for clinical strategies. Tankyrases can be inhibited by small molecule inhibitors and will thus be useful targets for clinical therapies in aging and cancer.,95099,ZRG1,Special Emphasis Panel,,7,303461,
7742636,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095137-07,,NCI:298050;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LANIER, LEWIS L;",1945373;,5R01CA095137,04/01/2002,01/31/2014,"21+ years old; Abscission; Address; Adult; Anchors, Glycosylphosphatidylinositol; Atrophic Arthritis; Autoimmune; Autoimmune Diabetes; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Bacteria; Biological Models; Blood Serum; Blood leukocyte; Body Tissues; Bone Marrow; Cancer Patient; Cancers; Celiac Disease; Cell surface; Cellular biology; Clinical Evaluation; Clinical Testing; Communicable Diseases; Cytotoxic cell; Dendritic Cells; Detection; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Disease; Disorder; Excision; Extirpation; Family; GPI; GPI Membrane Anchors; Gastrointestinal Tract, Pancreas; Gluten Enteropathy; Gluten-Sensitive Enteropathy; Gly-PtdIns; Glycoinositol Phospholipid Membrane Anchor; Glycosyl-Phosphatidylinositol; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Glycosylated Phosphatidylinositols; Glycosylphosphatidylinositols; Goals; Grafting, Heart; Heart Transplantation; Histocompatibility Complex; Histocompatibility Complices; Host Defense; Human; Human, Adult; Human, General; IDD; IDDM; Immune; Immune response; Immunity; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammatory Arthritis; Insulin-Dependent Diabetes Mellitus; Investigators; Islet Cell; K lymphocyte; Leukocytes; Ligands; Major Histocompatibility Complex; Major Histocompatibility Complices; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mediating; Mice; Mice, Transgenic; Model System; Models, Biologic; Murine; Mus; NK Cells; Natural Killer Cells; Organ; Pancreas; Pancreas Cancer; Pancreas Neoplasms; Pancreatic; Pancreatic Cancer; Pancreatic Tumor; Pathway interactions; Proteins; Receptor Protein; Removal; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Leukocytes; Rheumatoid Arthritis; Role; Serum; Solid; Sprue, Celiac; Sprue, Nontropical; Surgical Removal; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Thymus-Dependent Lymphocytes; Tissues; Transgenic Mice; Transplantation, Cardiac; Tumor Cell; Tumor of the Pancreas; Type 1 diabetes; Veiled Cells; Virus; Viruses, General; White Blood Cells; White Cell; adult human (21+); autoimmune disorder; cardiac graft; cell biology; cell type; clinical test; disease/disorder; gene product; heart transplant; host response; idiopathic steatorrhea; immunoresponse; insight; insulin dependent diabetes; interest; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; malignancy; meetings; mouse model; neoplasm/cancer; neoplastic cell; pancreatic neoplasm; pathogen; pathway; pre-clinical; preclinical; public health relevance; receptor; research clinical testing; resection; selective expression; selectively expressed; self recognition (immune); social role; therapeutic target; thymus derived lymphocyte; tumor; type I diabetes; white blood cell; white blood corpuscle",NK Cell Biology," Project Narrative NKG2D is a receptor on a class of white blood cells (NK cells and T cells) that has been demonstrated to provide protective immunity against pathogens and tumors, as well as implicated in the rejection of bone marrow and heart transplants and in certain autoimmune diseases, including rheumatoid arthritis, celiac disease, and type I diabetes. In this project, we propose to develop new mouse model systems in which we can study how tumors attempt to evade detection by the NKG2D receptor, and the importance of the NKG2D receptor in the host response against tumors and autoimmunity.",95137,TTT,"Transplantation, Tolerance, and Tumor Immunology",,7,298050,
7790609,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095175-07,,NCI:304354;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"SCULLY, RALPH ;",2266274;,5R01CA095175,05/01/2002,01/31/2014,"Accounting; Affect; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Articulation; Assay; BRCA1; BRCA1 Mutation; BRCA1 gene; BRCA2; BRCA2 Mutation; BRCA2 gene; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Breast; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer 2 Gene; Breast Cancer 2, Early Onset Gene; Breast Cancer Type 1 Susceptibility Gene; Breast Cancer Type 2 Susceptibility Gene; CHIP assay; Cancer Genes; Cancer Susceptibility Gene; Cancer of Breast; Cancer of the Ovary; Cancer-Predisposing Gene; Cancer-Promoting Gene; Cancers; Cell Cycle; Cell Division Cycle; Cell Line; Cell Lines, Strains; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chromatids; Complement; Complement Proteins; Culturing, in vitro Vertebrate, Primary; Cytofluorometry, Flow; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Recombination; DNA Repair; DNA Replicating Damage; DNA Replication; DNA Replication Damage; DNA Synthesis; DNA biosynthesis; DNA recombination (naturally occurring); Data; Defect; Deoxyribonucleic Acid; Double Strand Break Repair; Elements; Emerogenes; Enzymes; FANCB; FANCD1; Familial Breast Carcinoma; Familial Breast and Ovarian Cancer Syndrome; Familial Cancer of the Breast; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; G2 Phase; G2 period; Gap Phase 2; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Genetics-Mutagenesis; Genome Instability; Genomic Instability; Germ-Line Mutation; Germline Mutation; Hereditary; Hereditary Breast Cancer; Hereditary Breast Cancer 1; Hereditary Breast Cancer 2; Hereditary Breast Carcinoma; Hereditary Breast and Ovarian Cancer; Hereditary Breast and Ovarian Cancer Syndrome; Hereditary Mutation; Human; Human, General; Inherited; Joints; Laboratories; Life; Lifetime Risk; Link; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Ovary; Malignant neoplasm of breast; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Mice; Microfluorometry, Flow; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutation; Mutation of the BRCA1 Gene; Mutation of the BRCA2 Gene; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; PSCP; Pathway interactions; Predisposition gene; Primary Cell Cultures; Process; Proteins; RNF53; Recombination; Recombination, Genetic; Reporter; Risk; Risk Factors; Role; Second Gap Phase; Sister Chromatid; Site; Susceptibility Gene; Techniques; Testing; Transforming Genes; Translating; Translatings; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Unscheduled DNA Synthesis; Woman; Work; base; brca 1 gene; brca 2 gene; chromatin immunoprecipitation; cultured cell line; experiment; experimental research; experimental study; flow cytophotometry; gene product; genome mutation; homologous recombination; improved; innovate; innovation; innovative; language translation; malignancy; malignant breast neoplasm; mutant; neoplasm/cancer; novel; oncosuppressor gene; ovarian cancer; pathway; predisposing gene; prevent; preventing; public health relevance; repair; repaired; research study; social role; tumor suppressor",Analysis of BRCA1 recombination functions," Project Narrative If a woman inherits an error in a vital anti-cancer gene, BRCA1, she will have a greatly (~10-fold) increased risk of breast and ovarian cancer throughout her life; however, we do not understand precisely how the loss of BRCA1 function leads to cancer. New discoveries in our laboratory suggest that BRCA1 is needed for a process called ""sister chromatid recombination"" - a way of accurately repairing DNA breaks that arise as cells grow and divide. In this proposal, we will conduct experiments to find out whether BRCA1's tumor suppressor function is linked to its ability to repair broken DNA by sister chromatid recombination.",95175,CG,Cancer Genetics Study Section,,7,304354,
7777829,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095195-07,,NCI:251664;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"DATTA, PRAN K;",6879913;,5R01CA095195,04/01/2002,01/31/2014,"Accounting; Adherence; Adherence (attribute); Anchorage-Independent Growth; Animal growth regulators, transforming growth factors; Award; CAM 120/80; CCND1 Protein; CLDN1; CLG4B; Cadherin-1; Cancer Induction; Carcinoma; Carcinoma in Situ; Carcinoma of the Large Bowel; Carcinoma of the Large Intestine; Carcinoma, Intraepithelial; Carcinoma, Preinvasive; Cell Communication and Signaling; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Proliferation Regulation; Cell Signaling; Cellular Expansion; Cellular Growth; Cellular Migration; Cellular Proliferation; Cold-Insoluble Globulins; Colon Cancer; Colon Carcinoma; Colon Neoplasms; Colon or Rectum; Colonic Carcinoma; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Colorectal; Colorectal Cancer; Colorectal Carcinomas; Colorectal Neoplasms; Complex; Cyclin D1; Data; Disease; Disorder; Disseminated Malignant Neoplasm; Down-Regulation; Down-Regulation (Physiology); Downregulation; E-Cadherin; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Calcium-Dependent Adhesion Protein; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epithelial-Cadherin; Epithelium; FN1; FNZ; Fibronectin 1; Fibronectins; Frequencies (time pattern); Frequency; G-Beta Repeat; G1/S-Specific Cyclin D1; GELB; GUD; Gene Expression; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth; Hepatic Neoplasm Secondary; Hepatic metastasis; Human; Human, General; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; LETS Proteins; Large External Transformation-Sensitive Protein; Large Intestine Carcinoma; Large Intestine Neoplasm; Large Intestine Tumor; Lead; Liver Metastasis; Liver secondaries; Liver secondary cancer; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MMP9; MMP9 gene; MMPs; Malignant Cell; Malignant neoplasm of liver, specified as secondary; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Neoplasm to the Liver; Metastatic Tumor; Metastatic Tumor to the Liver; Metastatic malignant neoplasm to liver; Metastatic neoplasm of liver; Modeling; Molecular; Motility; Motility, Cellular; Mutation; Neoplasm Metastasis; Neoplasm of the Large Bowel; Oncogenic; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; PRAD1 Protein; PRKM8; Pathway interactions; Pb element; Play; Protein Binding; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proto-Oncogene Proteins c-bcl-1; Receptor Protein; Regulation; Reporting; Resistance; Role; SAPK1; STRAP protein, mouse; Secondary Neoplasm; Secondary Tumor; Secondary malignancy of liver; Secondary malignant neoplasm of liver; Serine Kinase; Serine-Threonine Kinases; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Threonine Kinase; Tissue Growth; Transducers; Transforming Growth Factors; Trp-Asp Repeat; Tryptophan-Aspartate Repeat; Tumor Cell Migration; Tumor Growth Factors; Tumor Suppressor Proteins; Tumor of the Colon; Tumor of the Large Bowel; Tumorigenicity; Tumors, Colorectal; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uvomorulin; WAGR; WD Domain; WD Repeat; WD40 Domain; WT1; WT1 gene; WT33; Wilms Tumor 1; alpha 2-Surface Binding Glycoprotein; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; cancer cell; cancer metastasis; cancer progression; carcinogenesis; cell growth; cell motility; claudin-1; claudin-1 protein; clinical relevance; clinically relevant; colorectal neoplasia; cyclin D; disease/disorder; drug development; epithelial carcinoma; epithelial to mesenchymal transition; genome mutation; heavy metal Pb; heavy metal lead; improved; in situ cancer; liver metastases; malignant phenotype; metastatic cancer to liver; metastatic colorectal; migration; neoplasm progression; neoplastic progression; novel; ontogeny; pathway; protein E; public health relevance; receptor; receptor expression; resistant; response; serine-threonine kinase receptor-associated protein; serine-threonine kinase receptor-associated protein, mouse; social role; transcription factor; tumor; tumor progression; tumor suppressor",STRAP and Smad 7 Signaling in Colorectal Carcinomas," Narrative The loss of transforming growth factor-ss (TGF-ss)-induced tumor suppressor function in tumors plays a pivotal role in the transition from normal colorectal epithelium, to in situ carcinoma, and finally invasive and metastatic cancers. We will investigate the mechanism of function of oncogenic STRAP and its crosstalk with Smad7 in colorectal cancer progression and metastasis. A better understanding of these mechanisms will help to improve drug development and treatment of this lethal disease.",95195,TME,Tumor Microenvironment Study Section,,7,251664,
7759507,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095274-07,,NCI:288083;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,PATHOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"KOGAN, SCOTT C;",2094616;,5R01CA095274,04/01/2002,01/31/2014,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 1-Phosphatidylinositol 3-Kinase; AML - Acute Myeloid Leukemia; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATRA; Acute Promyelocytic Leukemia; Address; After Care; After-Treatment; Aftercare; All-trans retinoic acid; Alleles; Allelomorphs; American; BING2; Behavior; Binding Sites; Biology; Blood (Leukemia); Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Precursor Cell; Blood Segmented Neutrophil; Blood monocyte; CAGA; CD135; CGLA; Cancers; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Characteristics; Chromosomal dislocation; Chromosomal translocation; Chromosome 8; Chromosomes, Human; Chromosomes, Human, Pair 8; Combining Site; Complement; Complement Proteins; Coupled; Cytokine Receptors; Cytokine Signal Transduction; Cytokine Signaling; DAP6; DAXX; DAXX gene; Development; Diagnosis; Dimerization; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EAP1; Ensure; Environment; Event; FLK2; FLT3; FLT3 gene; Gain of Chromosome 8; Gene Copy Number; Gene Dosage; Gene Down-Regulation; Gene Expression; Gene Fusion; Gene Targeting; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Hematopoietic stem cells; Heterophil Granulocyte; Homo; Human; Human Chromosomes; Human, General; Immune; In Vitro; Investigation; Knowledge; LEUKCL; Leukemia, Myelocytic, Acute; Leukemias, General; Leukemic Cell; Leukemogenesis/Lymphomagenesis; Limulus factor C; MA387; MRP8; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Transgenic; Modeling; Molecular; Mother Cells; Murine; Mus; Mutation; Myeloblastic Leukemia, Acute; Myelogenous; Myelogenous Leukemia, Acute; Myeloid; Myeloid Cells; Myeloid Leukemia, Acute, M3; Myelopoiesis; NR1B1; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nuclear Protein; Nuclear Proteins; Oncogene Products; Oncogene Proteins; Oncoproteins; PI-3 Kinase; PI-3K; PI3-Kinase; Pathogenesis; Pathway interactions; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Site; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Premyelocytes; Pressure; Pressure- physical agent; Progenitor Cells; Progenitor Cells, Hematopoietic; Progranulocytes; Progranulocytic Leukemia; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Promyelocyte; Protein Dimerization; Protein Phosphorylation; PtdIns 3-Kinase; RARA; RARA gene; Reactive Site; Receptors, Cytokine; Repression; Retinoic Acid; Retinoic Acid Receptor Alpha Gene; Retroviridae; Retroviruses; Role; S100A8; S100A8 gene; STK1; Series; Site; Staging; Stem cells; System; System, LOINC Axis 4; Targetings, Gene; Tissue Growth; Trans Vitamin A Acid; Transcription Repression; Transcriptional Repression; Transgenic Mice; Translocation, Genetic; Transplant-Related Disorder; Transplantation; Tretinoin; Tretinoinum; Trisomy 8; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Variant; Variation; Virus-Retrovirus; Vitamin A Acid; Warkany syndrome 2; Work; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; all-trans-Retinoic Acid; all-trans-Vitamin A acid; cell sorting; cell transduction; cellular transduction; chromosome 15 trisomy; chromosome 8 gain; chromosome 8 trisomy syndrome; chromosome dislocation; chromosome translocation; disease/disorder; effective therapy; factor C; fusion gene; gene repression; genome mutation; hDAXX; horseshoe crab factor C; human stem cells; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; kinase inhibitor; leukemia; leukemogenesis; malignancy; monocyte; mouse model; neoplasm/cancer; neutrophil; novel; ontogeny; overexpression; pathway; pressure; prevent; preventing; progenitor; promyelocytic leukemia; public health relevance; response; self-renewal; shRNA; short hairpin RNA; small hairpin RNA; social role; trans-Retinoic Acid; transcription factor; transduced cells; transplant; transplant disease; trisomy 15; trisomy 15 syndrome; vector",Molecular Mechanisms of Leukemogenesis by PMLRAR alpha," Project Narrative  Acute myeloid leukemia will be diagnosed in approximately 12,000 Americans this year and, despite improvements in treatment, more than 9,000 will die as a result of their disease. The proposal seeks to understand how genetic changes combine to cause leukemia. The results of the proposed studies should help us to understand acute myeloid leukemia and thereby should aid the development of new treatments for leukemias and other cancers.",95274,CAMP,Cancer Molecular Pathobiology Study Section,,7,288083,
7777833,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095548-07,,NCI:263704;,2010,NATIONAL CANCER INSTITUTE,,AUSTIN,UNITED STATES,BIOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"IYER, VISHWANATH R;",1896252;,5R01CA095548,04/01/2002,01/31/2014,"Address; Affect; Area; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; CHIP assay; Cancers; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Structure; Complex; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Injury; Data; Data Set; Dataset; Defect; Disease; Disorder; Epiphyseal Plate; Epiphysial cartilage; Eukaryota; Eukaryote; Eukaryotic Cell; GWAS; Gene Action Regulation; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Generalized Growth; Genes; Genes, Regulator; Genetic Transcription; Genome; Genomics; Goals; Growth; Growth Plate; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Homolog; Homologous Gene; Homologue; Human; Human, General; Individual; Light; Liquid substance; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Model System; Modeling; Models, Biologic; Molecular Interaction; Normal Cell; Nutrient; Pathway interactions; Phenotype; Photoradiation; Physiologic; Physiological; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA Expression; Regulation; Regulator Genes; Regulatory Element; RegulatoryElement; Relative; Relative (related person); Research; Role; Specificity; Spottings; Starvation; Stress; System; System, LOINC Axis 4; Testing; Tissue Growth; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transcriptional Regulatory Elements; Yeasts; biological adaptation to stress; cancer cell; chromatin immunoprecipitation; computer based prediction; disease/disorder; eukaryotida; experiment; experimental research; experimental study; fluid; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; liquid; malignancy; member; neoplasm/cancer; ontogeny; overexpression; pathway; predictive modeling; programs; public health relevance; reaction; crisis; regulatory gene; research study; response; social role; stress response; stress; reaction; trans acting element; transcription factor; whole genome association studies; whole genome association study",Analysis of genome wide transcriptional control in yeast," Analysis of genome-wide transcriptional control in yeast This project will use the stress response in yeast as a model system to understand the global regulation of gene expression under physiological perturbation. Homologs of many of the transcriptional regulators active during this process in yeast, such as Heat Shock Factor and other factors that affect chromatin are directly implicated in cancer in mammalian cells. A global functional gene regulatory network such as we propose to construct will shed considerable light on the mechanism of global gene regulation in mammalian cells that is often impaired in disease.",95548,GCAT,"Genomics, Computational Biology and Technology Study Section",,7,263704,
7758728,R01,CA,5,,02/01/2010,01/31/2011,PA-07-177,5R01CA095568-08,,NCI:664123;,2010,NATIONAL CANCER INSTITUTE,,ALBUQUERQUE,UNITED STATES,,01,045911138,US,NM,87108,LOVELACE BIOMEDICAL & ENVIRONMENTAL RES,"BELINSKY, STEVEN A;",1884990;,5R01CA095568,04/01/2002,01/31/2013,"(S)-2-Amino-4-(methylseleno)butanoic Acid; 1(2H)-Phthalazinone, hydrazone; 2(1H)-Pyrimidinone, 4-amino-; 2,4-Thiazolidinedione, 5-004-02-((((methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-; 4-Phenylbutyric Acid, Sodium Salt; 5-((4-(2-methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate; A/J Mouse; Abscission; Adjuvant Chemotherapy; Adverse effects; Agonist; Apresoline; Apressin; Assay; Avandia; Bioassay; Biologic Assays; Biological Assay; Blood; Blood Plasma; COAD; COPD; Cancer Cause; Cancer Etiology; Cancer Patient; Cancer Prevention, Secondary; Cancer of Lung; Cancers; Carcinogen exposure; Carcinoma, Non-Small-Cell Lung; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Chemotherapy, Adjuvant; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Clinical Trials; Clinical Trials, Unspecified; Colorado; CpG Islands; CpG-Rich Islands; Curative Surgery; Cytosine; Death; Development; Diagnosis, clinical; Disease; Disorder; Drug Combinations; Drug Therapy, Adjuvant; Drugs; ECOG; Eastern Cooperative Oncology Group; Enrollment; Epidemic; Excision; Extirpation; Funding; Future; Genes; Genetic; Glaxo Wellcome brand of rosiglitazone maleate; GlaxoSmithKline brand of rosiglitazone maleate; Goals; Grant; Guanosine; HDAC Agent; Histone Deacetylase Inhibitor; Human; Human, General; Hydralazine; Hydrazinophthalazine; Hypermethylation; Individual; Invasive Lesion; L-Selenomethionine; L-selenomethionine (Selenium); Lung; Lung Cancer screening; Lung Neoplasms; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Skin; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Medication; Melanoma and Non-Melanoma Skin Cancer; Methylation; Mortality; Mortality Vital Statistics; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Nested Case-Control Study; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; PPAR; Participant; Patients; Peroxisome Proliferator-Activated Receptors; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase I/II Trial; Phenylbutyrates; Plasma; Population; Pre-Malignant; Premalignant; Prevalence; Prevent skin cancer; Prevention; Prevention of Lung Cancer; Prevention of Skin Cancer; Primary Neoplasm; Primary Tumor; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Pulmonary Cancer; Pulmonary Disease, Chronic Obstructive; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; Recurrence; Recurrent; Removal; Reporting; Research; Resected; Respiratory System, Lung; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Sampling; Screening for Lung Cancer; Se element; SeMet; Secondary Cancer Prevention; Secondary Prevention; Selenium; Sensitivity and Specificity; Serum, Plasma; Skin Cancer; Skin Cancer, Including Melanoma; SmithKline Beecham brand of rosiglitazone maleate; Smoker; Sodium 4-phenylbutyrate; Sodium phenylbutyrate; Sputum; Staging; Study, Nested Case-Control; Supplementation; Surgical Removal; Testing; Time; Treatment Side Effects; Tumor of the Lung; Work; Yeasts; anticarcinogenic; biomarker; cancer chemoprevention; cancer prevention; cancer recurrence; cancer risk; chemoprevention of cancer; clinical Diagnosis; clinical investigation; cohort; disease/disorder; drug/agent; enroll; high risk; lung cancer; lung cancer early detection; lung cancer prevention; malignancy; mouse model; neoplasm/cancer; nonsmall cell lung cancer; precancerous; prevent; preventing; pulmonary; resection; response; rosiglitazone; side effect; skin cancer prevention; standard care; therapy adverse effect; treatment adverse effect; tumor",Biomarkers to Assess Selenium Chemoprevention for NSCLC,,95568,CBSS,Cancer Biomarkers Study Section,,8,664123,
7789619,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA095614-07,,NCI:562544;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"ELLIS, MATTHEW J;",1959354;,5R01CA095614,04/01/2002,12/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile); 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile); 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile); ACOSOG; Active Follow-up; Address; Adjuvant; Adjuvant Therapy; Affect; After Care; After-Treatment; Aftercare; Algorithms; Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; American College of Surgeons Oncology Group; Anastrozole (Arimidex); Androstenedione Aromatase Inhibitor; Arimidex; Aromatase Inhibitors; Assay; Astra brand of anastrozole; AstraZeneca brand of anastrozole; Atlases; Award; Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-; Bioassay; Biologic Assays; Biologic Marker; Biological Assay; Biological Markers; Biopsy; Breast; Cancer Relapse; Cancer of Breast; Cancers; Categories; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; Cellular Proliferation; Cessation of life; Characteristics; Classification; Clinical; Clinical Course of Disease; Clinical Trials, Phase II; Collaborations; Comparative Genome Hybridization; Complementary DNA; DNA; DNA Alteration; DNA Sequence; DNA mutation; DNA, Complementary; Data; Data Set; Dataset; Death; Defect; Deoxyribonucleic Acid; Dependence; Developing Countries; Developing Nations; Development; Diagnosis; Diagnostic; Disease; Disorder; Drugs; ER Status; Endocrine; Endocrine Therapy; Ensure; Estrogen Receptor Status; Estrogen Receptors; Estrogen Synthase Inhibitor; Estrogen Synthetase Inhibitor; Estrogen receptor positive; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Expression Profiling; Expression Signature; FLR; Failure (biologic function); Femara; Forecast of outcome; Formalin; Funding; GWAS; Gene Alteration; Gene Amplification; Gene Copy Number; Gene Dosage; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profile; Gene Expression Profiling; Gene Mutation; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genome; Genomics; Goals; Grant; Health Care Costs; Health Costs; Healthcare Costs; Hormonal Therapy; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ; Individual; Induction Therapy; Investigation; Investigators; Label; Less-Developed Countries; Less-Developed Nations; Letrozole; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measurement; Medical; Medication; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Molecular Fingerprinting; Molecular Marker; Molecular Profiling; Morbidity; Morbidity - disease rate; Mutation; NEOADJ; Neoadjuvant; Neoadjuvant Therapy; Neoadjuvant Treatment; Novartis Brand of Letrozole; Oophorectomy; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Ovariectomy; Paraffin Embedding; Pathological Staging; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 2 Clinical Trials; Phase II Clinical Trials; Phenotype; Preoperative Endocrine Therapy; Profilings, Gene Expression; Prognosis; Programs (PT); Programs [Publication Type]; Progressive Disease; R01 Mechanism; R01 Program; RNA, Messenger; RPG; Randomized; Relapse; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Specimen; Researchers; Resistance; Risk; SCHED; SUBGP; Safety; Sampling; Schedule; Sequence Alteration; Series; Signature Molecule; Somatic Mutation; Specimen; Speed; Speed (motion); Staging; Structure; Study Type; Subgroup; Surgical; Surgical Interventions; Surgical Procedure; Survival Rate; Switzerland; Systematics; TAM; Tamoxifen; Techniques; Technology; Testing; Therapeutic Estrogen; Third-World Countries; Third-World Nations; Toxic effect; Toxicities; Training; Transcript Expression Analyses; Transcript Expression Analysis; Translating; Translatings; Tumor Bank; Tumor Tissue; Under-Developed Countries; Under-Developed Nations; United States; Universities; Validation; Washington; Woman; Work; Zeneca brand of anastrozole; anastrazole; anastrozole; base; biomarker; cDNA; cancer genome; chemotherapy; clinical practice; comparative genomic hybridization; design; designing; disease/disorder; drug/agent; elderly patient; failure; female gonadectomy; follow-up; gene discovery; gene expression signature; genome mutation; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hormone therapy; improved; indexing; insight; language translation; mRNA; mRNA Expression; malignancy; malignant breast neoplasm; microarray technology; molecuar profile; molecular signature; natural gene amplification; neoplasm/cancer; novel; older patient; outcome forecast; phase 2 study; phase 2 trial; phase II trial; prognostic; programs; protocol, phase II; public health relevance; randomisation; randomization; randomized trial; randomly assigned; receptor function; repository; resistance to therapy; resistant; resistant to therapy; response; study design; study, phase II; surgery; therapy resistant; tissue fixing; tool; transcriptome; tumor; whole genome association studies; whole genome association study",NOVEL BIOMARKERS FOR AROMATASE INHIBITOR THERAPY," Project Narrative The principle treatment for estrogen receptor positive (ER+) breast cancer is endocrine therapy but tumor response is highly variable. Our inability to reliably predict tumor sensitivity to often leads to additional treatments, particularly chemotherapy to try and ensure the best outcome, even though these costly and poorly tolerated drugs are not necessary for many patients with responsive disease. This application will deliver a suite of clinical tests that will not only predict response to endocrine therapy but will define the full repertoire of molecular defects in endocrine therapy resistant tumors so new and more effective targeted therapies can be designed.",95614,CONC,Clinical Oncology Study Section,,7,562544,
7799925,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA095681-08,,NCI:265863;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,OBSTETRICS & GYNECOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"VADLAMUDI, RATNA K;",6884204;,5R01CA095681,02/01/2002,01/31/2014,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Anabolism; Androstenedione Aromatase Inhibitor; Aromatase Inhibitors; Breast; Breast Neoplasms; Breast Tumors; Cancer Biology; Cancer Treatment; Cancer of Breast; Cell Communication and Signaling; Cell Cycle Progression; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell model; Cellular Oncogene; Cellular Proliferation; Cellular biology; Cellular model; Code; Coding System; Combined Modality Therapy; Complex; Coupling; Cytoplasm; DNA Molecular Biology; Data; Diagnosis; Disease; Disease-Free Survival; Disorder; Endocrine Therapy; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Cells; Estrogen Receptors; Estrogen Synthase Inhibitor; Estrogen Synthetase Inhibitor; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Event; Event-Free Survival; Funding; GFAC; Gene Targeting; Gene Transcription; Generalized Growth; Genetic Transcription; Genomics; Glutamic Acid; Goals; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Histones; Hormonal; Hormonal Therapy; Human; Human, General; In Vitro; Intracellular Communication and Signaling; L-Glutamic Acid; L-Leucine; L-Proline; Lead; Leucine; Leucine, L-Isomer; Malignant; Malignant - descriptor; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Method LOINC Axis 6; Methodology; Molecular; Molecular Biology; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Neoplasm Metastasis; Oncogenesis; Pathologic Processes; Pathological Processes; Pathology; Pb element; Peripheral; Phosphorylation; Physiologic; Physiological; Play; Proline; Protein Phosphorylation; Proteins; Proteomics; Proto-Oncogenes; RNA Expression; Reagent; Research; Resistance; Resistance development; Resistant development; Role; SERMs; Science of Statistics; Secondary Neoplasm; Secondary Tumor; Selective Estrogen Receptor Modulators; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Statistics; TAM; Tamoxifen; Targetings, Gene; Testing; Therapeutic Estrogen; Therapeutic Intervention; Tissue Growth; Transcription; Transcription, Genetic; Transgenic Organisms; Tumor Cell Migration; Work; anticancer therapy; base; biological signal transduction; biomarker; biosynthesis; c-ONC; cancer metastasis; cancer progression; cancer therapy; cell biology; chromatin modification; clinical significance; clinically significant; combination therapy; combined modality treatment; combined treatment; developing resistance; disease/disorder; gene product; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; histone modification; hormone therapy; improved; in vivo Model; innovate; innovation; innovative; intervention development; intervention therapy; malignant breast neoplasm; mammary tumor; membrane structure; mouse model; multimodality therapy; neoplasm progression; neoplastic progression; next generation; non-genomic; nongenomic; novel; ontogeny; prognostic; protooncogene; public health relevance; receptor function; resistance to therapy; resistant; resistant to therapy; social role; statistics; therapy development; therapy resistant; transgenic; treatment development; tumor; tumor progression; tumorigenesis","PELP1, a Novel Regulator of Estrogen Receptor"," Project Narrative The human estrogen receptor (ER) is a key regulator in breast cancer biology. Our proposed research is clinically significant as it will define the role(s) of ER coregulator PELP1 as a critical proto-oncogene of breast cancer progression. Further, our proposed studies establishes the role of ER-PELP1 axis in metastasis and hormonal resistance and thus provide a novel target for combination therapies to treat metastatic and advanced breast tumors.",95681,MCE,Molecular and Cellular Endocrinology Study Section,,8,265863,
7758326,R01,CA,5,,02/01/2010,01/31/2011,PAR-06-459,5R01CA096504-08,,NCI:621974;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,ENGINEERING (ALL TYPES),08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"WITTRUP, KARL D;",1901720;,5R01CA096504,09/13/2002,01/31/2013,"Affinity; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibodies; Antigenic Determinants; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Autocrine Systems; Binding; Binding (Molecular Function); Binding Determinants; Biochemical; Biodistribution; Biomedical Engineering; Cancer Drug; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chemotherapeutic Agents, Neoplastic Disease; Clinical Trials; Clinical Trials, Unspecified; Cold-Insoluble Globulins; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cues; Cytoplasm; Data; Diffusion; Dimerization; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Kinetics; Drugs; EC 2.7; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR-TK Inhibitor; ERBB Protein; ERBB1; Elements; Engineering; Engineerings; Enzymatic Biochemistry; Enzymology; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epitope Mapping; Epitopes; Event; FN1; FNZ; Fibronectin 1; Fibronectins; Fluorescence; Fluorescence Microscopy; Gamma Globulin, 7S; Generalized Growth; Generations; Genetic Engineering of Proteins; Growth; HER1; Heterograft; High Throughput Assay; Homo; IgG; Image; Immunoglobulin G; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Kinases; Kinetic; Kinetics; L-Tyrosine; LETS Proteins; Large External Transformation-Sensitive Protein; Lead; Ligand Binding; Ligands; METBL; MSKCC; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Measures; Medical Imaging; Medical Imaging, Positron Emission Tomography; Medication; Membrane; Memorial Sloan-Kettering Cancer Center; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular; Molecular Interaction; Murine; Mus; Network Analysis; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; PTK Receptors; Pathway Analysis; Pb element; Penetration; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacodynamics; Pharmacokinetics; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Photons; Physicians; Positron Emission Tomography Scan; Positron-Emission Tomography; Process; Programs (PT); Programs [Publication Type]; Protein Dimerization; Protein Engineering; Protein Phosphorylation; Proteomics; Proton Magnetic Resonance Spectroscopic Imaging; RTK; Rad.-PET; Reagent; Receptor Activation; Receptor Inhibition; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Research; Research Personnel; Researchers; Scientist; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Surface; System; System, LOINC Axis 4; TYR; Techniques; Therapeutic; Therapeutic antibodies; Tissue Growth; Transforming Growth Factor alpha Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Transplantation, Heterologous; Tumor-Specific Treatment Agents; Tyrosine; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Phosphorylation; Tyrosine, L-isomer; Validation; Work; X Ray Crystallographies; X-Ray Crystallography; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; Yeasts; alpha 2-Surface Binding Glycoprotein; antibody engineering; anticancer agent; anticancer drug; anticancer therapy; autocrine; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer therapy; cell engineering; cellular engineering; clinical investigation; cultured cell line; design; designing; dimer; directed evolution; dosage; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; extracellular; heavy metal Pb; heavy metal lead; high throughput screening; imaging; improved; in vivo; interest; malignancy; membrane structure; migration; mutant; neoplasm/cancer; novel; ontogeny; para-Tyrosine; pre-clinical; preclinical; programs; proto-oncogene protein c-erbB-1; receptor; receptor downregulation; response; structural biology; trafficking; tumor",Engineered Antibody EGFR Antagonist Cancer Therapeutics,,96504,ZRG1,Special Emphasis Panel,,8,621974,
7758744,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA096511-07,,NCI:278677;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,PATHOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"VIRGIN, HERBERT W;",1865936;,5R01CA096511,07/23/2002,01/31/2013,"0-11 years old; Acute; Angiitis; Antiviral Agents; Antiviral Drugs; Antivirals; Benign; Biological Models; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CMV; Cancers; Cells; Cells, CD4; Child; Child Youth; Children (0-21); Chronic; Cytomegalovirus; Data; Elements; Funding; Gene Expression; Gene Transcription; Genes; Genes, Viral; Genetic; Genetic Polymorphism; Genetic Transcription; Grant; HCMV; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesviridae; Herpesviridae Infections; Herpesviridae disease; Herpesvirus Infections; Herpesvirus hominis; Herpesviruses; Human; Human, Child; Human, General; IFN; Immune; Immune response; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoactivators; Immunoadjuvants; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Adjuvants; Immunologic, Immunochemical; Immunological Adjuvant; Immunologics; Immunopotentiators; Immunostimulants; Immunosuppressed Host; In element; Indium; Infection; Infection Control; Interferons; Isoforms; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi?s Sarcoma; Lead; Life; Lymphoproliferative Disorders; Lytic; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Maps; Mice; Mice, Mutant Strains; Model System; Modeling; Models, Biologic; Mouse herpesvirus strain 68; Multiple Hemorrhagic Sarcoma; Murid herpesvirus 4; Murine; Murine herpesvirus 68; Mus; Mutant Strains Mice; Natural Immunity; Nature; Norovirus; Norwalk-like Viruses; Oncogenesis; Pathogenesis; Pb element; Physiologic; Physiological; Polymorphism (Genetics); Polymorphism, Genetic; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Proteins; RNA Expression; Receptor Protein; Regulation; Reporting; Response Elements; Role; Salivary Gland Viruses; Science of Virology; Simplexvirus; Site; System; System, LOINC Axis 4; T4 Cells; T4 Lymphocytes; Testing; Training; Transcript; Transcription; Transcription, Genetic; Transplantation; Vaccinated; Vasculitis; Viral; Viral Genes; Viral Genetics; Virology; Virus; Viruses, General; Work; abstracting; base; body system, allergic/immunologic; children; cytokine; cytomegalovirus group; experiment; experimental research; experimental study; gammaherpesvirus; gene product; heavy metal Pb; heavy metal lead; helper T cell; herpes virus; herpesvirus; host response; human cytomegalovirus; human herpesvirus 1 group; immune adjuvant; immunoresponse; immunosuppressed patient; in vivo; lymphoproliferative disease; malignancy; mouse development; mouse model; mouse mutant; neoplasm/cancer; novel; organ system, allergic/immunologic; pathogen; polymorphism; prevent; preventing; professor; programs; reactivation from latency; receptor; research study; social role; transplant; tumorigenesis; virology; virus genetics; youngster",IMMUNOLOGIC CONTROL OF GAMMAHERPESVIRUS LATENCY,,96511,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,7,278677,
7790697,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA096679-06,,NCI:306143;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"LOW, DANIEL A;",6120554;,5R01CA096679,07/01/2002,12/31/2013,"3-D Imaging; 3D imaging; Accounting; Air; Algorithms; Analysis, Data; Artifacts; Aspiration, Respiratory; Atomic Medicine; Behavior; Body Tissues; Breathing; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancer Patient; Cancer Radiotherapy; Cancer of Lung; Characteristics; Clinical; Complex; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Coupled; Data; Data Analyses; Discipline of Nuclear Medicine; Distant; Dose; EMI scan; Evolution; Future; Goals; Grant; Human; Human, General; IMRT; Image; Image Reconstructions; Imaging, Three-Dimensional; Inhalation; Inhaling; Inspiration, Respiratory; Intensity Modulated RT; Intensity Modulated Radiation Therapy; Intensity-Modulated Radiotherapy; Linear Accelerator; Linear Accelerator Radiotherapy Systems; Lung; Lung Neoplasms; Lung Parenchyma; Lung Tissue; Lung diseases; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Maps; Math Models; Measurement; Measures; Medical Imaging, Three Dimensional; Methods; Methods and Techniques; Methods, Other; Modeling; Modification; Monitor; Morbidity; Morbidity - disease rate; Morphologic artifacts; Motion; Nuclear Medicine; Organ; Patients; Pattern; Performance; Physiology; Position; Positioning Attribute; Pressure; Pressure- physical agent; Process; Pulmonary Cancer; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Neoplasms; Pulmonary imaging; Pulmonary malignant Neoplasm; Radiation; Radiation therapy; Radiology / Radiation Biology / Nuclear Medicine; Radiology-Nuclear Medicine; Radiotherapeutics; Radiotherapy; Radiotherapy Systems, Linear Accelerator; Reconstructions, Image; Research; Residual; Residual state; Resolution; Respiration; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory physiology; Scanning; Science of Statistics; Spirometry; Statistics; Structure; Structure of parenchyma of lung; Techniques; Three-Dimensional Imaging; Tidal Volume; Time; Tissues; Tomodensitometry; Tomography, Computed, Scanners; Tomography, Xray Computed; Tumor Tissue; Tumor of the Lung; Variant; Variation; Work; X-Ray Computed Tomography; base; cancer radiation therapy; catscan; computed axial tomography; computerized axial tomography; computerized tomography; data modeling; density; heuristics; image registration; imaging; improved; inspiration; irradiation; lung cancer; lung disorder; lung function; lung imaging; lung scanning; mathematical model; mathematical modeling; model development; novel; pressure; public health relevance; pulmonary; ray (radiation); reconstruction; respiratory airway volume; respiratory function; respiratory mechanism; statistics; treatment planning; tumor",LUNG TRAJECTORY MAPPING FOR RADIATION THERAPY," We are developing a mathematical description of human breathing motion for use in radiation treatments of lung cancer. The description uses imaging data acquired using sophisticated computed tomography (CT) scans that are acquired while the patient's breathing is monitored. The CT acquisition and analysis methods will be developed to maximize the model performance and the performance will be measured in lung-cancer and non-lung cancer radiation therapy patients. If the motion model is found to be accurate, it may have applications outside of radiation therapy.",96679,RTB,Radiation Therapeutics and Biology Study Section,,6,306143,
7797649,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA096824-07,,NCI:254676;,2010,NATIONAL CANCER INSTITUTE,,COLLEGE STATION,UNITED STATES,BIOLOGY,17,141582986,US,TX,77845,TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR,"WANG, FEN ;",6838703;,5R01CA096824,07/01/2002,01/31/2014,"ATP[{..}]protein-tyrosine O-phosphotransferase; Ablation; Adaptor Protein; Adaptor Signaling Protein; Alleles; Allelomorphs; American; Androgenic Agents; Androgenic Compounds; Androgens; Animal Model; Animal Models and Related Studies; Animals; Assay; Attenuated; Autoregulation; BEK; BFR-1; Basal Cell; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Body Tissues; Cancer Cause; Cancer Diagnostics; Cancer Etiology; Cancer Patient; Cancer of Prostate; Cancers; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; DNA Synthesis Factor; Data; Death; Development; Diagnostics, Cancer; Dietary Component; EC 2.7; ECGF; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endothelial Cell Growth Factor; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial; Epithelial Cells; FGF; FGF-R; FGFBR; FGFR; FGFR1; FGFR1 gene; FGFR2; FGFR2 gene; FLG Gene; FLT2 Gene; FMS-Like Gene; FMS-Like Tyrosine Kinase 2 Gene; FRS2; FRS2 gene; FRS2A; FRS2alpha; Fibroblast Growth Factor; Fibroblast Growth Factor Receptor 1 Gene; Fibroblast Growth Factor Receptor 2 Gene; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Fibroblast Growth Regulatory Factor; Future; Generalized Growth; Genetically Engineered Mouse; Genital System, Male, Prostate; Growth; HBGF; HEK3; Health; Healthcare Systems; Homeostasis; Human Prostate; Human Prostate Gland; Hyperplasia of Prostate Gland; Immune Escape, Tumor; In Vitro; Interruption; Intracellular Communication and Signaling; Isoforms; KGFR Gene; KSAM-1; Keratinocyte Growth Factor Receptor Gene; Kinases; Life; Life Expectancy; Light; Link; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mediating; Methods; Molecular; Morphogenesis; Mother Cells; Natural regeneration; Nutrition; Nutritional Science; Oncogenesis; PTK; Pathway interactions; Phosphotransferases; Photoradiation; Physiological Homeostasis; Play; Population; Prevention strategy; Preventive Intervention; Preventive strategy; Process; Progenitor Cells; Prostate; Prostate CA; Prostate CA therapy; Prostate Cancer; Prostate Cancer therapy; Prostate Gland; Prostate Neoplasms; Prostatic; Prostatic Cancer; Prostatic Gland; Prostatic Hyperplasia; Prostatic Neoplasia; Prostatic Neoplasms; Prostatic hypertrophy; Protein Isoforms; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; QOL; Quality of life; Receptor Protein; Receptor Signaling; Receptors, FGF; Regeneration; Regulation; Role; SNT; SNT-1; Science of nutrition; Second Cancer; Second Primary Cancers; Secondary Malignancy; Secondary Malignancy (After Treatment of Primary Cancer); Secondary Malignant Neoplasm; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Staging; Stem cells; Structure; Subcellular Process; Systems Analyses; Systems Analysis; Systems, Health Care; TK14; Technology; Testing; Therapeutic Androgen; Tissue Growth; Tissues; Transphosphorylases; Tumor Cell; Tumor Escape; Tumor of the Prostate; Tumorigenicity; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; base; biological signal transduction; cancer initiation; cancer progression; cultured cell line; design; designing; hydroxyaryl protein kinase; improved; in vivo; male; malignancy; model organism; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; nutrition; ontogeny; pathway; precursor cell; prevent; preventing; preventional intervention strategy; prostate hyperplasia; public health relevance; receptor; regenerate; secondary cancer; social role; tool; tumor; tumor initiation; tumor progression; tumorigenesis; tyrosyl protein kinase",FRS2-mediated Signals in Prostatic Tumorigenesis and Development," Project Narrative Prostate cancer is the most diagnostic cancer and the second leading cause of cancer death in American males. Like normal prostates, prostate cancer at early stages is androgen dependent. Yet, at late stages, prostate cancer frequently progresses to androgen independent and becomes malignant. Aberrant cell signaling, including signals mediated by FRS2a, often found accompanying the progression to malignancy, which confers autonomous growth and invasion capability to tumor cells. This project is to use genetically engineered mouse models and in vitro biochemical and molecular biological methods to study the roles of FRS2a-mediated signals in prostate development and tumorigenesis.",96824,MONC,Molecular Oncogenesis Study Section,,7,254676,
7796857,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA096943-07,,NCI:287704;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,OTHER HEALTH PROFESSIONS,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SHLOMCHIK, WARREN D;",2048706;,5R01CA096943,09/01/2002,01/31/2014,"ABD-B; Aberrant Chromosome; Abnormalities, Chromosomal; Address; Affect; Affinity; Allogenic; Allografting; Animals; Antibodies; Apoptosis; Apoptosis Pathway; Avidity; B7-1; BB1; Biology; Blast Cell; Blast Crisis; Blast Phase; Blast Phase CML; Blast Phase Chronic Granulocytic Leukemia; Blast Phase Chronic Myelocytic Leukemia; Blast Phase Chronic Myelogenous Leukemia; Blast Phase Chronic Myeloid Leukemia; Blastic Phase CML; Blastic Phase Chronic Granulocytic Leukemia; Blastic Phase Chronic Myelocytic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myeloid Leukemia; Blasts; Blood (Leukemia); Blood Cells; Blood leukocyte; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; CD134L; CD28LG; CD28LG1; CD54 (ICAM 1); CD54 Antigens; CD80; CD80 gene; CTL assay; Cancers; Causality; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Survival; Cell Viability; Cell-Death Protease; CellLine; Cells; Cessation of life; Chromosomal Aberrations; Chromosomal Alterations; Chromosomal, Gene, or Protein Abnormality; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Chronic Phase; Chronic Phase CML; Chronic Phase Chronic Granulocytic Leukemia; Chronic Phase Chronic Myelocytic Leukemia; Clinical; Clinical Research; Clinical Study; Complementary DNA; Complex; Cytofluorometry, Flow; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytogenetic or Molecular Genetic Abnormality; DNA, Complementary; Data; Death; Disease Resistance; Etiology; Family member; Ferrata cell; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; GP34; GVL; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Genetic Abnormality; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Goals; Graft vs Leukemia Effect; Graft-vs-Leukemia Response; Grafting, Bone Marrow; Granulocytic Leukemia, Chronic, Stable-Phase; HOX1.7; HOX1G; HOXA9; HOXA9 gene; Hematohistioblast; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Cancer; Hemocytoblast; Hemohistioblast; Homeobox A9; Human; Human, General; ICAM-1; ICE-like protease; ITX; Immune; Immunologically Directed Therapy; Immunotherapy; Impairment; In Vitro; In complete remission; Infusion; Infusion procedures; Inherited Predisposition; Inherited Susceptibility; Intercellular adhesion molecule 1; Jordan; Killings; Knockout Mice; LAB7; Leukemia, Granulocytic, Chronic-Phase; Leukemia, Myelogenous, Chronic-Phase; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Stable-Phase; Leukemia, T-Cell; Leukemias, General; Leukocytes; Ligands; Lymphocytic Leukemia, T-Cell; MGC1934; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Hematologic Neoplasm; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Marrow leukocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Minority; Modeling; Molecular Abnormality; Mother Cells; Murine; Mus; Myelogenous Leukemia, Chronic, Chronic-Phase; Myeloid Disease; Myeloid Leukemia, Chronic, Chronic-Phase; Myeloid Leukemia, Chronic, Stable-Phase; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; NUP96 Gene; NUP98; NUP98 gene; Neoplasms; Nucleoporin, 98-kD Gene; Null Mouse; OVA-8; OX40L; Ovalbumin; Pathology; Pathway interactions; Patients; Peptides; Peripheral Blood Cell; Persons; Phenotype; Physiologic pulse; Population; Predisposition; Profilings, Gene Expression; Progenitor Cell Transplantation; Progenitor Cells; Publishing; Pulse; Receptor Protein; Receptors, Antigen, T-Cell; Recurrence; Recurrent; Relapse; Research; Resistance; Resistance, Disease; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Leukocytes; Retroviridae; Retroviruses; Risk; SIINFEKL peptide; Sorting - Cell Movement; Source; Stem Cell Leukemia; Stem Cell Transplantation; Stem cell transplant; Stem cells; Sum; Susceptibility; System; System, LOINC Axis 4; T-Cell Depletion; T-Cell Leukemia; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocytic Leukemia; TNFSF4; TNFSF4 gene; TXGP1; Testing; Thymus-Dependent Lymphocytes; Transcript Expression Analyses; Transcript Expression Analysis; Transgenic Organisms; Tumors; Virus-Retrovirus; White Blood Cells; White Cell; Work; base; cDNA; caspase; cell killing; complete response; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; flow cytophotometry; fusion gene; genetic etiology; genetic manipulation; genetic mechanism of disease; genetic vulnerability; immune therapy; in vivo; leukemia; malignancy; mouse model; myeloproliferative neoplasm; neoplasia; neoplasm/cancer; neoplastic growth; novel; ovalbumin (257-264); overexpression; pathway; progenitor; public health relevance; receptor; research study; resistance to disease; resistance to therapy; resistant; resistant disease; resistant to disease; resistant to therapy; retroviral transduction; shRNA; short hairpin RNA; small hairpin RNA; sorting; stemness; therapy resistant; thymus derived lymphocyte; transgenic; white blood cell; white blood corpuscle",Leukemia Stem Cells: Essential Targets for GVL and Mediators of GVL-Resistance," Many people die from cancers of blood cells. Frequently immune cells, given as part of a bone marrow transplant from another person, are used to try to cure these patients. Unfortunately, for reasons that are unknown, many cancers are resistant to this therapy and this proposal will investigate the biology underlying this differential sensitivity.",96943,CII,Cancer Immunopathology and Immunotherapy Study Section,,7,287704,
7760107,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA096983-08,,NCI:331906;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,OTHER BASIC SCIENCES,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"CASTILLA, LUCIO H.;",1930222;,5R01CA096983,08/01/2002,01/31/2012,"AML - Acute Myeloid Leukemia; Affect; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood (Leukemia); Blood Precursor Cell; Bone-Derived Transforming Growth Factor; CBF; CBF-Beta; CBFB; CBFB protein, human; Cancer Genes; Cancer-Promoting Gene; Cancers; Cell Communication and Signaling; Cell Signaling; Chromosomal dislocation; Chromosomal translocation; Chromosome 16; Chromosomes, Human, Pair 16; Clonal Expansion; Code; Coding System; Core-Binding Factor; Core-Binding Factor Beta; Core-Binding Factor, Beta Subunit; Development; Funding; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Human; Human, General; In Vitro; Insertional Mutagenesis; Intracellular Communication and Signaling; Investigators; KIAA0866; Knock-in; Knock-in Mouse; LEUKCL; Leukemia, Myelocytic, Acute; Leukemias, General; Leukemic Cell; MYH11; MYH11 gene; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Micro RNA; MicroRNAs; Milk Growth Factor; Modeling; Molecular; Murine; Mus; Mutagenesis, Insertional; Mutation; Myeloblastic Leukemia, Acute; Myelogenous; Myelogenous Leukemia, Acute; Myeloid; Myosin Heavy Chains; Oncogenes; Oncogenic; PEA2-Beta; PEBP2-Beta; PEBP2B; PEBP2B protein, human; Pathway interactions; Platelet Transforming Growth Factor; Play; Polyomavirus Enhancer Binding Protein 2 Beta Subunit; Process; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Research Personnel; Researchers; Role; SL3-3 Enhancer Factor 1 Beta Subunit; SL3/AKV Core-Binding Factor Beta Subunit; Signal Transduction; Signal Transduction Systems; Signaling; TGF B; TGF-beta; TGFbeta; Testing; Tissue Growth; Transforming Genes; Transforming Growth Factor beta; Translocation, Genetic; Transplantation; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; biological signal transduction; cancer cell; chromosome dislocation; chromosome translocation; core-binding factor, beta subunit protein, human; design; designing; experiment; experimental research; experimental study; fusion gene; genome mutation; human CBFB protein; improved; in vivo; leukemia; malignancy; miRNA; mouse model; myosin heavy chain; neoplasm/cancer; ontogeny; overexpression; pathway; polyomavirus enhancer binding protein 2, beta subunit protein, human; progenitor; programs; research study; self-renewal; social role; stem cell differentiation; transcription factor; transplant",Cooperating genes in inv (16) acute myeloid leukemia,,96983,HP,Hematopoiesis Study Section,,8,331906,
7810601,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA097022-08,,NCI:297592;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,PATHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"KLEMKE, RICHARD L.;",1878821;,5R01CA097022,07/01/2002,02/28/2013,"ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Address; Animal Model; Animal Models and Related Studies; Animals; Assay; Back; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Body Tissues; Breast; Cancer Model; CancerModel; Cancers; Candidate Disease Gene; Candidate Gene; Carcinoma Cell; Cell Communication and Signaling; Cell Culture System; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Extracellular Matrix; CellLine; Cells; Cellular Migration; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Data; Devices; Diagnosis; Disease; Disorder; Disseminated Malignant Neoplasm; Distant; Dorsum; EC 2.7; ECM; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Expression Profiling; Expression Signature; Extracellular Matrix; Extracellular Matrix, Integrins; Gastrointestinal Tract, Pancreas; Gene Proteins; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Differentiation; Genetic Divergence; Genetic Drift; Genetic defect; Goals; Growth Factor Receptors; HEK3; Human; Human, General; Image; In Vitro; Integrins; Intracellular Communication and Signaling; Invaded; Investigators; Kinases; Knock-out; Knockout; Laboratories; Left; Life; Lymph node proper; Malignant Cell; Malignant Epithelial Cell; Malignant Melanoma; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Messenger RNA; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Mice, Transgenic; Microscopy; Molecular; Molecular Fingerprinting; Molecular Profiling; Motility; Motility, Cellular; Murine; Mus; Mutation; Neoplasm Metastasis; Organ; Organelles; Ovarian; PTK; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pathway interactions; Patients; Phenotype; Phosphoproteins; Phosphorylation Site; Phosphotransferases; Photons; Play; Population; Primary Neoplasm; Primary Tumor; Process; Programs (PT); Programs [Publication Type]; Protein Gene Products; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proteomics; Proto-Oncogene, Growth Factor Receptor; Pseudopodia; Publishing; RNA, Messenger; Receptor Activation; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Lymph Node; Role; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; System; System, LOINC Axis 4; Technology; Testing; Time; Tissues; Transgenic Mice; Transphosphorylases; Transplantation; Tumor Cell Migration; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Validation; Variant; Variation; Vascular remodeling; Work; angiogenesis; biological signal transduction; biomarker; cancer cell; cancer metastasis; cancer progression; cell motility; cultured cell line; design; designing; disease/disorder; established cell line; gene product; genetic profiling; genome mutation; hydroxyaryl protein kinase; imaging; in vivo; knockout gene; lymph gland; lymph nodes; mRNA; malignancy; melanoma; metastatic process; model organism; molecuar profile; molecular signature; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; new therapeutic target; novel; pathway; programs; protein profiling; response; shRNA; short hairpin RNA; small hairpin RNA; social role; transplant; true biomarker; tumor; tumor progression; tyrosyl protein kinase",Survival Mechanisms of Invasive Carcinoma Cells,,97022,TCB,Tumor Cell Biology Study Section,,8,297592,
7761205,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA097096-07,,NCI:263381;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,BIOCHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"RAMSDEN, DALE A;",6121425;,5R01CA097096,07/01/2002,01/31/2013,"Address; Biological; Cancers; Cell Cycle; Cell Division Cycle; Cells; Cellular Assay; Chromosomal Breaks; Chromosome Break; Chromosomes; Collaborations; DNA; DNA Damage; DNA Injury; DNA Polymerases; DNA Replication; DNA Sequence Rearrangement; DNA Synthesis; DNA biosynthesis; DNA polymerase beta 2; DNA polymerase beta2; DNA polymerase lambda; DNA polymerase mu; DNA polymerase, Pol lambda; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Dependence; Double Strand Break Repair; EC 2.7.7.7; Electromagnetic Radiation, Ionizing; Elements; Enzymes; Family; Genetic; Genetics-Mutagenesis; Genome; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunoglobulin V(D)J Rearrangement; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; In Vitro; Ionizing radiation; Lead; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Molecular Biology, Mutagenesis; Mutagenesis; Oncogenesis; Pathway interactions; Pb element; Pol beta2; Pol mu; Polymerase; Predisposition; Radiation; Radiation Sensitivity; Radiation Tolerance; Radiation-Ionizing Total; Radiosensitivity; Rearrangement; Relative; Relative (related person); Reliance; Research; Role; Structure; Susceptibility; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; Work; abstracting; base; cell killing; cell type; heavy metal Pb; heavy metal lead; homologous recombination; hypoimmunity; immune deficiency disorder; immunodeficiency; improved; malignancy; member; mutant; neoplasm/cancer; pathway; preference; ray (radiation); repair; repaired; social role; structural biology; tumor; tumorigenesis",The Role of DNA Synthesis in Nonhomologous End Joining,,97096,RTB,Radiation Therapeutics and Biology Study Section,,7,263381,
7793492,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA097131-07,,NCI:265727;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,UROLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"JARRARD, DAVID F;",1890053;,5R01CA097131,07/01/2002,01/31/2014,"21+ years old; 3,4',5-stilbenetriol; 3,5,4'-trihydroxystilbene; ASM; ASM1; Address; Adult; Age; Aging; Aging Process; Aging-Related Process; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Autocrine Systems; Binding; Binding (Molecular Function); Body Tissues; Caloric Restriction; Cancer of Prostate; Cancerous; Cancers; Causality; Cause of Death; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell model; Cells; Cellular Proliferation; Cellular model; D11S813E; DNA Methylation; Defect; Dependence; Development; Diagnosis; Diet; Dietary Intervention; Disease; Disease Progression; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Emerogenes; Enhancers; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Cells; Etiology; Event; Funding; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Imprinting; Genital System, Male, Prostate; Genomic Imprinting; Goals; Grant; H19; H19 gene; Histologic; Histologically; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, General; IGF-2; IGF-II; IGF2; IGF2 gene; Insulin-Like Growth Factor 2; Insulin-Like Growth Factor II; Insulin-Like Somatomedin Peptide II; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Link; Lobe; MGC4485; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods; Methylation; Mice; Microdissection; Minor; Modification; Molecular; Molecular Interaction; Multiplication-Stimulating Activity; Multiplication-Stimulating Factor; Murine; Mus; NKX3-1 gene; NKX3.1; NKX3A; Nutrition Interventions; Nutritional Interventions; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Organ; Oxidative Stress; Parental Imprinting; Pathway interactions; Pattern; Peripheral; Play; Population; Position; Positioning Attribute; Predisposition; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Protein Methylation; Proteins; Regulation; Repression; Research; Research Personnel; Researchers; Resveratrol; Risk; Role; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somatomedin A; Somatomedin MSA; Specificity; Susceptibility; Testing; Tissues; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor of the Prostate; adult human (21+); age dependent; age related; aging population; autocrine; base; biological signal transduction; calorie restriction; cancer diagnosis; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gene product; human tissue; imprint; in vivo; interventional strategy; male; malignancy; men; men's; mouse model; neoplasm/cancer; new therapeutics; next generation therapeutics; novel; novel therapeutics; oncosuppressor gene; overexpression; paracrine; pathway; prevent; preventing; prostate carcinogenesis; public health relevance; senescence; senescent; social role; tumor",Modulation of IGF-II Imprinting in the Aging Prostate," Why prostate cancer develops with aging is unclear, yet the impact of this disease in the aging population is significant and expected to increase. We have defined a novel epigenetic change, the loss of IGF2 imprinting, that occurs with aging and identifies men who have developed the disease. We seek to further define this change in order to develop new therapies to prevent cancer, as well as develop new methods for diagnosing prostate cancer and predicting risk of developing the disease.",97131,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,7,265727,
7803000,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA098372-07,,NCI:240092;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,OTOLARYNGOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"GRANDIS, JENNIFER RUBIN;",1872406;,5R01CA098372,12/01/2002,01/31/2014,"70-kDa Ribosomal Protein S6 Kinases; ADAM-17; Address; Anti-Cancer Agents; Anti-EGFR Monoclonal Antibody; Anti-Epidermal Growth Factor Receptor Monoclonal Antibody; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Autocrine Systems; Body Tissues; Bombesin Receptor; COX-2; COX2; Cancer Drug; Cancers; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Communication and Signaling; Cell Signaling; Cetuximab; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clinical Protocols; Drugs; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR-TK Inhibitor; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; FDA approved; Funding; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; GPCR Signaling; Gastrin releasing peptide; Gastrin-Releasing Peptide (1-27); Generalized Growth; Goals; Grant; Growth; Growth Factor Receptors; HER1; HNSCC; Head and Neck; Head and Neck Cancer; Head and Neck Carcinoma; Head and Neck Neoplasm (Excluding Central Nervous System); Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Laboratories; Ligands; Malignant Cell; Malignant Head and Neck Neoplasm; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Head and Neck; Man (Taxonomy); Man, Modern; Mediating; Medication; Moab, Clinical Treatment; Modeling; Molecular Target; Monoclonal Antibodies; NMBR; Oncogenic; Outcome; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoproteins; Phosphorylation; Pre-Clinical Model; Preclinical Models; Primary Neoplasm; Primary Tumor; Protein Phosphorylation; Protein-Tyrosine Kinases, src; Proto-Oncogene, Growth Factor Receptor; Publications; Receptor Activation; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Gastrin-Releasing Peptide; Receptors, Neuromedin B; Regimen; Regulatory Pathway; Reporting; Resistance; Ribosomal Protein S6 Kinases, 70-kDa; Role; SCCHN; Scientific Publication; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Squamous Cell Epithelioma; Squamous cell carcinoma; Study models; TACE (enzyme); TNF-alpha converting enzyme; Testing; Therapeutic; Tissue Growth; Tissues; Transforming Growth Factor alpha Receptor; Tumor of the Head and Neck; Tumor-Specific Treatment Agents; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; anticancer agent; anticancer drug; autocrine; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer progression; cohort; combinatorial; design; designing; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; hCOX-2; head & neck cancer; head & neck tumor; head and neck tumor; improved; in vivo; malignancy; mammalian bombesin; meetings; neoplasm progression; neoplasm/cancer; neoplastic progression; ontogeny; p70 S6 Kinase; p70s6k; pathway; pre-clinical; preclinical; protein expression; proto-oncogene protein c-erbB-1; public health relevance; receptor expression; receptor-mediated signaling; resistance mechanism; resistant; resistant mechanism; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; therapeutic development; therapeutic target; tumor; tumor growth; tumor necrosis factor alpha convertase; tumor necrosis factor-alpha converting enzyme; tumor progression",GPCR Signaling in SCCHN: Integration with EGFR," The proposed studies will elucidate the mechanisms of resistance to EGFR targeting strategies in preclinical models of squamous cell carcinoma of the head and neck. Specifically, we will test the hypothesis that persistent G-protein-coupled receptor (GPCR) signaling in the setting of EGFR blockade contributes to limited clinical responses to EGFR targeting in SCCHN. In addition, we will test the hypothesis that GPCR signaling contributes to cetuximab resistance in 2 SCCHN patient cohorts and that GPCR targeting in combination with EGFR blockade modulates expression of proteins and phosphoproteins in human SCCHN tumors from subjects treated on a clinical protocol.",98372,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,7,240092,
7805620,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA098468-07,,NCI:262200;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,CHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"REDINBO, MATTHEW ;",7883527;,5R01CA098468,02/01/2003,01/31/2014,"(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4'[{..}]6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione; (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate; 1,1,3,3,3-pentafluoro-2-(fluoromethoxy)-1-propene; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; Acute; Advanced Development; Adverse effects; Aerobic; Ali-esterase; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; B-esterase; Bacteria; Beta-glucuronidase; Biology; Brain; CAP-hydrolyzing Enzyme; CPT 11; Campto; Camptothecin-11; Cancer Drug; Cancers; Capsaicin-Hydrolyzing Enzyme; Carboxyesterase; Carboxylate Esterase; Carboxylester Lipase; Carboxylesterase B; Carboxylesterases; Carboxylic Ester Hydrolase; Carboxylic Ester Hydrolases; Cell Death, Programmed; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Coliform Bacilli; Colon; Complex; Compound A; DNA; DNA Double Strand Break; DNA Nicking-Closing Protein; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Topoisomerase I; DNA Topoisomerases, Type I; DNA Type 1 Topoisomerase; DNA Untwisting Enzyme; DNA Untwisting Protein; Deoxyribonucleic Acid; Diarrhea; Dose-Limiting; Drug Precursors; Drugs; Encephalon; Encephalons; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Enzymes; Exhibits; FDTVE; FDVE-2,2; Generations; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Glucuronidase; Goals; Gram-Negative Bacteria; Human; Human, General; Hydrolysis; Intermediary Metabolism; Intestinal; Intestines; Irinotecan (CPT-11, Camptosar); Isocarboxazid amidase; Liver; Lung; METBL; Malignant Neoplasms; Malignant Tumor; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mediating; Medication; Metabolic Processes; Metabolism; Microorganisms, General; Molecular; Mutation; Naproxen Esterase; Nervous System, Brain; Neural Stem Cell; Non-specific Carboxylesterase; Non-specific Esterase; Nonspecific Esterase; Oryctolagus cuniculus; Pharmaceutic Preparations; Pharmaceutical Preparations; Pro-Drugs; Procaine Esterase; Process; Prodrugs; Property; Property, LOINC Axis 2; Proteins; Rabbit, Domestic; Rabbits; Refractory; Respiratory System, Lung; SN-38; Solid; Structure; Structure-Activity Relationship; System; System, LOINC Axis 4; TOP1; TOP1 protein, human; Testing; Topo I; Topoisomerase I; Topoisomerase, DNA, I; Treatment Side Effects; Tumor Cell; Tumor-Specific Treatment Agents; Type I DNA Topoisomerase; Type I DNA Topoisomerases; Variant; Variation; [1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4'[{..}]6,7]indolizino[1,2-b]quinolin-9-yl ester; anticancer agent; anticancer drug; base; beta-D-Glucuronoside glucuronosohydrolase; body system, hepatic; bowel; camptosar; carboxylesterase; chemical structure function; design; designing; drug efficacy; drug/agent; fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether; gene product; genome mutation; human TOP1 protein; improved; in vivo; inhibitor; inhibitor/antagonist; irinotecan; leukemia/lymphoma; lymphoma/leukemia; malignancy; microorganism; neoplasm/cancer; neoplastic cell; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; nicking closing enzyme; novel; organ system, hepatic; pentafluoroisopropenyl fluoromethyl ether; prevent; preventing; public health relevance; pulmonary; relaxing enzyme; side effect; structure function relationship; swivelase; therapy adverse effect; tool; treatment adverse effect; tumor; untwisting enzyme",Improving CPT-11 Efficacy Using Structural and Chemical Biology," PROJECT NARRATIVE  While the anticancer drug CPT-11 is used widely to treat late-term solid malignancies, its efficacy is severely limited by acute side effects and poor in vivo activation. We will employ the tools of structural and chemical biology to understand CPT-11 processing and metabolism at the atomic level, and then use that information to improve the efficacy and systemic tolerance of this proven chemotherapeutic compound.",98468,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,7,262200,
7782691,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA098495-07,,NCI:274395;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"PAPAVASILIOU, F. NINA;",2088021;,5R01CA098495,04/01/2003,01/31/2013,"2,4(1H,3H)-pyrimidinedione; 2,4-dioxopyrimidine; 2,4-pyrimidinediol; 2-hydroxy-4-(3H)-pyrimidione; 4-hydroxy-2-(1H)-pyrimidione; ATGN; Affect; Animals; Antibodies; Antibody Affinity; Antibody Repertoire; Antibody Specificity; Antigens; Autoimmune Diseases; Autoimmune Status; Autoimmunity; B blood cells; B cell activating factor; B cell growth factor; B cell repertoire; B lymphoma; B-Cell Development; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binding; Binding (Molecular Function); Binetrakin; Bio-Informatics; Biochemical; Biochemistry; Bioinformatics; Bone Marrow; Bone-Derived Transforming Growth Factor; Bp50; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD40; CDW40; Cancer Genes; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Nucleus; Cell Signaling; Cells; Chemistry, Biological; Chromosomal dislocation; Chromosomal translocation; Class Switching; Closure by Ligation; Co-Immunoprecipitations; Code; Coding System; Complex; Cytidine; Cytidine Aminohydrolase; Cytidine Deaminase; Cytoplasm; Cytosine Ribonucleoside; Cytosine Riboside; Data; Deaminase; Deamination; Defect; Detection; GTF2D; GTF2D1; Gamma Globulin, 19S; Gene Conversion; Gene Transcription; Gene Transfer Techniques; Generation of Antibody Diversity; Generations; Genes; Genes, Ig; Genes, Immunoglobulin; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genome; Genome Stability; Genomics; Germinal Center; Germinoblastoma; Human; Human, General; IL-4; IL4; IL4 Protein; Ig Somatic Hypermutation; IgM; Immune Globulins; Immunoglobulin Class Switching; Immunoglobulin Genes; Immunoglobulin Isotype-Switch Recombination; Immunoglobulin M; Immunoglobulin Somatic Hypermutation; Immunoglobulin Switch Recombination; Immunoglobulin V(D)J Rearrangement; Immunoglobulins; Immunoglobulins / Antibodies; Infection; Infectious Diseases / Treatment, General; Interleukin-4; Interleukin-4 Precursor; Intracellular Communication and Signaling; Isotype Switching; Kinetic; Kinetics; Knowledge; Lead; Lesion; Ligation; Lymphocyte Stimulatory Factor 1; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MCGF-2; MGC9013; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Mediating; Milk Growth Factor; Molecular; Molecular Interaction; Mutation; Nucleus; Oncogenes; Pathway interactions; Pb element; Platelet Transforming Growth Factor; Point Mutation; Process; Production; Programs (PT); Programs [Publication Type]; Proteins; RNA Expression; RNA Polymerase II TATA-Binding Protein; Reaction; Regulation; Reticuloendothelial System, Bone Marrow; Reticulolymphosarcoma; SCA17; Sarcoma, Germinoblastic; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Solubility; Somatic Hypermutation, Immunoglobulin; Stability, Genomic; Stimulus; Structure of germinal center of lymph node; Switch Recombination; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; T-Cell Growth Factor 2; TATA Sequence-Binding Protein; TATA-Binding Protein; TATA-Box Binding Protein; TATA-Box Factor; TBP; TGF B; TGF-beta; TGFbeta; TNFRSF5; TNFRSF5 gene; Time; Transcription; Transcription Factor TBP; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transforming Genes; Transforming Growth Factor beta; Transgenesis; Translocation, Genetic; Travel; Treatment of Infectious Diseases; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Ung DNA glycosylase; Ura-DNA glycosidase; Ura-DNA glycosylase; Uracil; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; Vertebrate Animals; Vertebrates; antigen antibody affinity; autoimmune disorder; base; biological signal transduction; chromosome dislocation; chromosome translocation; cofactor; combat; cross-link; crosslink; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; immunogen; in vivo; infectious disease treatment; interest; novel; p50; pathway; programs; public health relevance; research study; self recognition (immune); somatic hypermutation; transcription factor; tumor; uracil N-glycosidase; uracil N-glycosylase; uracil-DNA glycosidase; uracil-DNA glycosylase; vertebrata",The Regulation of Somatic Hypermutation," Project Narrative The experiments proposed here are important for determining how beneficial mutation generates antibody specificities against foreign substances. The mutational process which we propose to study has been implicated in autoimmune diseases as well as in the generation of B cell lymphomas. Understanding the components involved in this process will help us gain better knowledge of the genetic and environmental causes of autoimmunity, as well as the treatment of infectious diseases and tumors.",98495,ZRG1,Special Emphasis Panel,,7,274395,
7763795,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA098555-07,,NCI:567736;,2010,NATIONAL CANCER INSTITUTE,,EUGENE,UNITED STATES,,04,053615423,US,OR,97403,OREGON RESEARCH INSTITUTE,"ANDREWS, JUDY A;",1900644;,5R01CA098555,03/01/2004,01/31/2012,"0-11 years old; 21+ years old; 3-D; 3-Dimensional; Active Follow-up; Active Learning; Address; Adult; Affect; Behavioral; Child; Child Youth; Children (0-21); Cognitive; Computer Systems Development; Computers; County; Curriculum; Decision Theory; Dependence, Nicotine; Development; Development, Computer Systems; Educational Curriculum; Effectiveness; Effectiveness, Program; Environment; Evaluation; Feasibility Studies; Feedback; Feeling; Funding; Future; Goals; Health Benefit; Home; Home environment; Human, Adult; Human, Child; Individual; Intranet; Learning, Experiential; Link; Mediating; Mission; Modeling; Nature; Newsletter; Nicotine Dependence; Oregon; Outcome; Parents; Phase; Prevention program; Process; Program Effectiveness; Programs (PT); Programs [Publication Type]; Qualitative Evaluations; Quantitative Evaluations; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Controlled Trials; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Risk; Schools; Smoke; Smoking; Students; Systems Development; Testing; Time; Tobacco; Tobacco Consumption; Tobacco use; Translating; Translatings; adult human (21+); base; children; computer network; design; designing; efficacy trial; experience; feelings; follow-up; innovate; innovation; innovative; language translation; middle school; nicotine addiction; novel; prevent; preventing; programs; prototype; public health relevance; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; response; risk perception; success; teacher; theories; tobacco prevention; tobacco use prevention; willingness; youngster",Intranet-Based Tobacco Prevention Program for Children,,98555,CLHP,Community-Level Health Promotion Study Section,,7,567736,
7762185,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA098727-08,,NCI:287704;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MOTHES, WALTHER H;",7055830;,5R01CA098727,03/12/2003,01/31/2013,"Actins; Animal Welfare; Bibliography; Biological Models; Capsid; Cell membrane; Cells; Cellular Membrane; Cellular biology; Co-culture; Cocultivation; Coculture; Coculture Techniques; Country; Cytoplasm; Cytoplasmic Membrane; Diffusion; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Filopodia; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Label; Life; Model System; Models, Biologic; Mouse Leukemia Viruses; Murine leukemia virus; Names; Plasma Membrane; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Retroviridae; Retroviruses; System; System, LOINC Axis 4; Transmission; Vertebrate Animals; Vertebrates; Viral; Virion; Virus; Virus Particle; Virus-Retrovirus; Viruses, General; abstracting; cell biology; coat (nonenveloped virus); expiration; human subject; novel; particle; plasmalemma; programs; receptor; transmission process; vertebrata",Cell Biology of Retrovirus Replication,,98727,VIRB,Virology - B Study Section,,8,287704,
7802246,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA098920-07,,NCI:346489;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MISCELLANEOUS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"POWIS, GARTH ;",1873277;,5R01CA098920,07/01/2003,01/31/2014,"21+ years old; Adult; Angiogenic Factor; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Basic Fibroblast Growth Factor Gene; Binding; Binding (Molecular Function); Blood Vessels; Body Tissues; Cancer Drug; Cancer Treatment; Cancers; Cell Death; Cell Death, Programmed; Cellular Expansion; Cellular Growth; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clinical Trials; Clinical Trials, Unspecified; DNA Binding; DNA Binding Interaction; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug effect disorder; Drug resistance; E3 Ligase; E3 Ubiquitin Ligase; Embryo Development; Embryogenesis; Embryonic Development; Endoplasmic Reticulum; Environment; Ergastoplasm; FGF2; FGF2 gene; FGFB; Factor, Angiogenesis; Fibroblast Growth Factor 2 Gene; Forecast of outcome; Generalized Growth; Genes; Goals; Grant; Growth; HIF 1; HIF-1 protein; HIF1; HIF1 protein; HSP; Heat shock proteins; Heel; Human; Human, Adult; Human, General; Hypoxia; Hypoxia Inducible Factor; Hypoxia-Inducible Factor Pathway; Hypoxia-Inducible Factor in the Cardiovascular System; Hypoxic; In Vitro; Intermediary Metabolism; Investigation; Lead; Ligase; METBL; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Metabolic Processes; Metabolism; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular; Molecular Interaction; Neoplasm Metastasis; Normal Tissue; Normal tissue morphology; Nuclear; O element; O2 element; Organism-Level Process; Organismal Process; Oxygen; Oxygen Deficiency; Pathway interactions; Patients; Pb element; Peptide Biosynthesis, Ribosomal; Perfusion; Physiologic Processes; Physiological Processes; Prognosis; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Inhibition; Protein Synthesis, Ribosomal; Proteins; RNA, Small Interfering; Radiation; Regulation; Resistance; Role; Screening procedure; Secondary Neoplasm; Secondary Tumor; Small Interfering RNA; Solid Neoplasm; Solid Tumor; Staging; Stress; Stress Proteins; Synthetases; Therapeutic; Therapeutic Intervention; Tissue Growth; Tissues; Translations; Tumor Cell; Tumor Cell Migration; Tumor-Specific Treatment Agents; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Up-Regulation; Up-Regulation (Physiology); Upregulation; adult human (21+); analog; angiogenesis; anticancer agent; anticancer drug; anticancer therapy; base; biological adaptation to stress; cancer cell; cancer metastasis; cancer therapy; cell growth; chemotherapy; clinical investigation; drug action; drug resistant; gene product; heavy metal Pb; heavy metal lead; hypoxia inducible factor 1; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; malignancy; necrocytosis; neoplasm/cancer; neoplastic cell; novel; ontogeny; outcome forecast; pathway; protein synthesis; public health relevance; rapid growth; ray (radiation); reaction; crisis; resistance to Drug; resistant; resistant to Drug; response; screening; screenings; siRNA; social role; stress protein; stress response; stress; reaction; transcription factor; tumor; tumor growth; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase; vascular",Hypoxia and Anticancer Drug Action," Project Narrative Hypoxic stress is a feature of all tumors as they grow and outstrip new blood vessel growth, but is not seen in most normal tissues. Tumors have developed mechanisms that allow them to grow in hypoxia, thus, providing an Achilles heel for selectively attacking the tumor. The goal of our studies is to understand these mechanisms in order to provide targets for the development of new types of cancer drugs and strategies for treating cancer",98920,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,7,346489,
7758309,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA100420-08,,NCI:266843;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"DONEHOWER, LAWRENCE A.;",7357739;,5R01CA100420,04/01/2003,01/31/2013,"ATM deficient; Affect; Antioncogene Protein p53; Assay; Back; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cancers; Candidate Disease Gene; Candidate Gene; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Tumor Antigen P53; Cellular injury; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Dephosphorylation; Dorsum; EC 2.7; Feedback; Fibroblasts; Gene Transcription; Genes; Genes, p53; Genetic Transcription; Genetically Engineered Mouse; Genomics; Goals; Grant; Human; Human, General; Intracellular Communication and Signaling; Kinases; Knockout Mice; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Murine; Mus; Mutagenesis, Site-Directed; Nucleotide Excision Repair; Null Mouse; Oncogenes; Oncogenesis; Oncogenic; Oncoprotein p53; Organism-Level Process; Organismal Process; P53; PPM1D; PPM1D gene; Pathology; Pathway interactions; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein P53; Phosphoprotein pp53; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiologic Processes; Physiological Processes; Play; Protein Dephosphorylation; Protein Serine/Threonine Phosphatase; Protein TP53; Protein p53; Proteins; RNA Expression; Regulation; Resistance; Rodent; Rodentia; Rodentias; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Stress; Structure; Structure-Activity Relationship; Subcellular Process; TP53; TP53 gene; TRP53; Targeted DNA Modification; Targeted Modification; Tissues; Transcription; Transcription, Genetic; Transforming Genes; Transphosphorylases; Tumor Protein p53; Tumor Protein p53 Gene; Unscheduled DNA Synthesis; biological signal transduction; cancer type; cell damage; cell injury; chemical structure function; d-Numb; gene product; in vivo; malignancy; malignant breast neoplasm; mitogen-activated protein kinase p38; mouse model; neoplasm/cancer; novel; numb protein; overexpression; p38 MAP Kinase; p38 MAPK; p38 Protein Kinase; p38 SAPK; p53 Antigen; p53 Tumor Suppressor; pathway; repair; repaired; resistant; response; serine-threonine phosphatase; social role; structure function relationship; tumor; tumorigenesis",Oncogenic Function of a P53-Induced Phosphatase,,100420,MONC,Molecular Oncogenesis Study Section,,8,266843,
7777309,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA100475-06,,NCI:349585;,2010,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PATHOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"FRIDMAN, RAFAEL A.;",1889156;,5R01CA100475,07/01/2003,01/31/2014,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Animal Cancer Model; AnimalModel; Attention; Biochemical; Biological; Biological Factors; Body Tissues; Cancer Patient; Cancers; Cause of Death; Cell-Extracellular Matrix; Chemicals; Detection; Development; ECM; Effectiveness; Esteroproteases; Extracellular Matrix; Factor, Biologic; Foundations; Funding; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Gelatinases; Generations; Goals; In Vitro; Inhibition of Matrix Metalloproteinases; Inhibition of Matrix Metalloproteinases Pathway; Laboratories; Libraries; MMP Inhibitor; MMP-14 gene product; MMP-2; MMP-9; MMP-9 Protein; MMP-X1; MMP14; MMP14 gene product; MMP14 protein, human; MMP2; MMP9; MMPs; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Macrophage Gelatinase; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinase-14; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Mediating; Membrane; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Molecular; Monitor; Murine; Mus; Natural Products; Neoplasm Metastasis; PEX; Peptidases; Peptide Hydrolases; Plant Resins; Process; Property; Property, LOINC Axis 2; Proteases; Protein Cleavage; Proteinases; Proteolysis; Proteolytic Enzymes; Reporting; Research; Resins, Plant; Role; SB 3CT compound; SB-3CT; Sampling; Secondary Neoplasm; Secondary Tumor; System; System, LOINC Axis 4; Testing; Tissues; Tumor Cell; Tumor Cell Migration; Tumor Tissue; Type V Collagenase; base; cancer cell; cancer metastasis; cancer progression; chemical synthesis; clinical significance; clinically significant; design; designing; human MMP14 protein; improved; in vivo; inhibitor; inhibitor/antagonist; intervention development; malignancy; membrane structure; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new approaches; novel; novel approaches; novel strategies; novel strategy; public health relevance; resin; small molecule; social role; therapeutic target; therapy development; trafficking; treatment development; tumor; tumor progression",Targeting MT-MMPs in Cancer Progression," Tumor dissemination and metastasis remain the major cause of death in cancer patients. Therefore, understanding the biological factors promoting these processes and developing therapies aimed at reducing tumor spread is of great clinical significance.",100475,DMP,Drug Discovery and Molecular Pharmacology Study Section,,6,349585,
7763798,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA100634-08,,NCI:328339;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","RUSSELL, STEPHEN J;",3171518;,5R01CA100634,04/04/2003,01/31/2013,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 131 Iodine; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Adexone; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; American; Amplidermis; Anemul mono; Anions; Antimicotico; Aquapred; Auxiloson; Azona; Baycuten; Baycuten N; Beta Particle; Beta Rays; Biodistribution; Blood Plasma Cell; Bone Marrow; Bone Marrow Stem Cell; Bortezomib; CD 46 antigen; CD46; CD46 Antigen; Cancers; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chloride Channels; Cistrons; Clinical; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Code; Coding System; Corson; Cortidexason; Cortisumman; Death; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deposit; Deposition; Deronil; Desamethasone; Desameton; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Dose; Drugs; Early-Stage Clinical Trials; Electromagnetic Radiation, Ionizing; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Future; Gammacorten; Genome; Goals; Grant; Head and Neck, Salivary Glands; Head and Neck, Thyroid; Heterograft; Hexadecadrol; Hexadrol; Human; Human, General; I-131; I131 isotope; Image; Imaging Procedures; Imaging Techniques; Immune; Immunocompetent; Infection; Iodides; Iodine I 131; Ion Channels, Chloride; Ionizing radiation; Isotopes; Kinetic; Kinetics; Lead; Lentiviral Vector; Lentivirus Vector; Lokalison-F; Loverine; MCP antigen; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measles; Measles virus; Mediating; Medication; Membrane; Methylfluorprednisolone; Mice; Millicorten; Mind; Modeling; Monitor; Multiple Myeloma; Murine; Mus; Myeloma, Plasma-Cell; Mymethasone; NIS Gene; NIS protein; Na(+),I(-)-cotransporter; Ocasa; Oncolytic; Orgadrone; Outcome; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Plasma Cells; Plasmacytes; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Proteasome Inhibitor; Radiation Protection; Radiation Sensitivity; Radiation Tolerance; Radiation, Beta; Radiation, Charged Particles-Electrons; Radiation-Ionizing Total; Radioactive Iodine; Radiosensitivity; Receptor Protein; Recombinants; Relative; Relative (related person); Reticuloendothelial System, Bone Marrow; Revlimid; Route; Rubeola; SLC5A5; SLC5A5 gene; Salivary Glands; Site; Sodium-Iodide Symporter Gene; Speed; Speed (motion); Spersadex; Spersadox; Stomach; Subcellular Process; Surface; TLX-B antigen; Technics, Imaging; Testing; Therapeutic; Therapeutic Index; Thyroid; Thyroid Gland; Time; Toxic effect; Toxicities; Transgenes; Transplantation; Transplantation, Heterologous; Treatment outcome; Tumor Cell; VSV; Vesicular Stomatitis Virus; Vesicular stomatitis Indiana virus; Virus; Viruses, General; Visumetazone; Work; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; attenuated measles virus; auricularum; base; cell killing; clinical investigation; clinical test; design; designing; disease/disorder; drug/agent; gastric; gp45-70 protein; heavy metal Pb; heavy metal lead; imaging; improved; in vivo; malignancy; membrane cofactor protein; membrane structure; morbilli; myeloma; myelomatosis; neoplasm/cancer; neoplastic cell; new approaches; novel approaches; novel strategies; novel strategy; phase 1 study; phase 1 trial; phase I trial; plasmocyte; progenitor; protocol, phase I; receptor; recombinant virus; research clinical testing; rougeole virus; rubeola virus; shRNA; short hairpin RNA; small hairpin RNA; sodium-iodide cotransporter; sodium-iodide symporter; subcutaneous; thyroid iodide transporter; transplant; tumor; tumor growth; uptake",Radiovirotherapy for Multiple Myeloma,,100634,RTB,Radiation Therapeutics and Biology Study Section,,8,328339,
7788873,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA100679-07,,NCI:324087;,2010,NATIONAL CANCER INSTITUTE,,PROVIDENCE,UNITED STATES,MISCELLANEOUS,01,001785542,US,RI,02912,BROWN UNIVERSITY,"KELSEY, KARL TIMOTHY;",1938293;,5R01CA100679,04/01/2003,01/31/2013,"Alcohol Drinking; Alcohol consumption; Alcohols; Algorithms; Allele Frequency; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Automobile Driving; Blood; CIMP; Cancer Causing Agents; Cancer Genes; Cancer Induction; Cancer-Promoting Gene; Cancers; Carcinogen exposure; Carcinogens; Case Series; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Causality; Cell Function; Cell Process; Cell physiology; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cessation of life; Characteristics; Chemical Class, Alcohol; Clinical; Colorectal Cancer; Companions; Complex; CpG Island Methylator Phenotype; CpG Islands; CpG-Rich Islands; Crossmatching, Tissue; DNA; DNA Alteration; DNA Damage Repair; DNA Methylation; DNA Repair; DNA mutation; Data; Death; Deoxyribonucleic Acid; Diagnosis; Diet; Disease; Disease Outcome; Disorder; Drivings, Automobile; Drug Therapy; EGFR; ERBB Protein; ERBB1; Emerogenes; Enrollment; Epidemiologic Methods; Epidemiological Methods; Epidemiological Techniques; Epidemiology, Methods; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; EtOH drinking; Etiology; Event; Exposure to; Expression Profiling; Expression Signature; Funding; Gene Alteration; Gene Expression; Gene Frequency; Gene Inactivation; Gene Mutation; Gene Silencing; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetic mutation; Genomics; HER1; HNSCC; HPV; HPV 16; HPV-16; HPV16; Head and Neck Cancer; Head and Neck Carcinoma; Head and Neck Squamous Cell Carcinoma; Heterogeneity; High Prevalence; Histocompatibility Testing; Human; Human Development; Human Papillomavirus; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus type 16; Human papillomavirus, type 16; Human, General; Hypermethylation; Individual; Infectious Human Wart Virus; Intervention; Intervention Strategies; Knowledge; Lead; Life Style; Lifestyle; Lifestyle Factors, Unspecified; Light; Link; Lung Adenocarcinoma; Malignant; Malignant - descriptor; Malignant Cell; Malignant Head and Neck Neoplasm; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tumor; Malignant Tumor of the Head and Neck; Malignant Tumor of the Mouth; Malignant neoplasm of mouth; Malnutrition; Man (Taxonomy); Man, Modern; Medical; Method LOINC Axis 6; Methodology; Methylation; Molecular; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Mouth Cancer; Mutation; Nutritional Deficiency; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Oncogens; Oral Cancer; Outcome; Papilloma Virus, Human; Papillomavirus, Human; Parents; Pathway interactions; Patients; Pattern; Pb element; Pharmacotherapy; Phenotype; Photoradiation; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Procedures; Progenitor Cells; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Publishing; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regulation; Relapse; Research Resources; Resources; Reticuloendothelial System, Blood; Risk; Risk Factors; SCCHN; SUBGP; Sequence Alteration; Smoking; Solid Neoplasm; Solid Tumor; Source; Stem cells; Subcellular Process; Subgroup; Susceptibility; Therapeutic; Tissue Crossmatchings; Tissue Typing; Tobacco smoking; Transforming Genes; Transforming Growth Factor alpha Receptor; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor-Suppressor Gene Inactivation; Undernutrition; United States; Unscheduled DNA Synthesis; Variant; Variation; Viral; Woman; Work; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic frequency; base; biomarker; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer type; carcinogenesis; cell growth; design; designing; dietary deficiency; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; driving; enroll; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; genome mutation; genome-wide; head & neck cancer; head & neck tumor; heavy metal Pb; heavy metal lead; histocompatibility typing; human papilloma virus 16; interventional strategy; kinase inhibitor; lifestyle factors; malignancy; malignant mouth neoplasm; molecuar profile; molecular phenotype; molecular signature; neoplasm/cancer; new approaches; non-smoking; novel approaches; novel strategies; novel strategy; oncosuppressor gene; oral carcinogenesis; pathway; polymorphism; population based; prevent; preventing; proto-oncogene protein c-erbB-1; public health relevance; success; tumor; tumorigenesis; volunteer; wart virus",Patterns of Somatic Gene Alterations in Oral Cancer," Project Narrative This project ""Patterns of Somatic Gene Alterations in Oral Cancer"" will investigate the relationship of the major risk factors for Head and Neck cancers with the pattern of inactivation of the major genes responsible for causing these tumors. We believe that the underlying patterns of gene changes may predict disease outcome and lead to new understanding of this cancer, enhancing our ability to both prevent and treat the disease.",100679,EPIC,Epidemiology of Cancer Study Section,,7,324087,
7802918,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA100693-06,,NCI:235445;,2010,NATIONAL CANCER INSTITUTE,,FORT COLLINS,UNITED STATES,NONE,04,785979618,US,CO,80523,COLORADO STATE UNIVERSITY-FORT COLLINS,"THOMPSON, HENRY J;",1867947;,5R01CA100693,04/01/2003,01/31/2014,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 5'-AMP-activated protein kinase; AKT; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; Accounting; Address; Aerobic; Affect; Akt protein; Apoptosis; Apoptosis Pathway; Attention; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior; Body Weight; Breast; Breast Cancer Prevention; Breast Carcinoma; Breast Neoplasms; Breast Tumors; Cancer Control; Cancer Control Science; Cancer Induction; Cancer Treatment; Cancer of Breast; Cancers; Carcinoma; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cellular Stress; Cellular Stress Response; Characteristics; Chronic Disease; Chronic Illness; Clinical Research; Clinical Study; Cohort Studies; Common Rat Strains; Computers; Concurrent Studies; Corticosterone; D-Glucose; Data; Dextrose; Differentiation Factor, B-Cell; Dose; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Estrogenic Agents; Estrogenic Compounds; Estrogens; Evaluation; Exercise; Exercise, Physical; Food; Frequencies (time pattern); Frequency; Funding; Gene Expression; Generalized Growth; Genes; Genes, p53; Gln; Glucose; Glutamine; Goals; Growth; Guidelines; HIF 1; HIF-1 protein; HIF1; HIF1 protein; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; HPGF; Head; Health; Health Benefit; Height; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IGF-1; IGF-I; IGF-I-SmC; IGF1; IL-6; IL6 Protein; Incidence; Individual; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Interleukin 6 (Interferon, Beta 2); Interleukin-6; International; Intracellular Communication and Signaling; Investigation; Knowledge; L-Glutamine; Laboratories; Link; Literature; MGI-2; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Rats; Mammary Cancer; Mammary Carcinoma; Mammary Glands, Human; Mammary Neoplasms; Mammary Tumorigenesis; Mammary gland; Man (Taxonomy); Man, Modern; Measurable; Mediating; Metabolic; Molecular; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Myeloid Differentiation-Inducing Protein; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Obesity; Over weight; Overweight; P53; PKB protein; Pathway interactions; PgR Status; Physical activity; Physiologic; Physiological; Plasmacytoma Growth Factor; Play; Population; Pre-Clinical Model; Preclinical Models; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Process; Progesterone Receptor Status; Programs (PT); Programs [Publication Type]; Protein Kinase B; Proto-Oncogene Proteins c-akt; Public Health; Q. Levoglutamide; RAC-PK protein; RAFT-1 gene product; Rapamune; Rapamycin; Rat; Rattus; Recommendation; Relative Risks; Reporting; Rewards; Risk; Risk Reduction; Risks, Relative; Role; Running; SUBCAT; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirolimus; Sirtuins; Somatomedin C; Subcategory; TP53; TP53 gene; TRP53; Testing; Therapeutic Estrogen; Tissue Growth; Translations; Tumor Burden; Tumor Expansion; Tumor Load; Tumor Protein p53 Gene; United States National Institutes of Health; Vascularization; Weight; Weight Gain; Weight Increase; Weight maintenance regimen; Woman; Work; adiposity; anticancer therapy; base; biological signal transduction; biomarker; body weight gain; body weight increase; c-akt protein; cancer prevention; cancer risk; cancer therapy; carcinogenesis; chronic disease/disorder; chronic disorder; corpulence; corpulency; corpulentia; cytokine; design; designing; disease prevention; disorder prevention; epithelial carcinoma; experiment; experimental research; experimental study; fork head protein; forkhead protein; forkhead transcription factors; hydroxymethylglutaryl-CoA-reductase kinase; hypoxia inducible factor 1; instrument; interferon beta 2; mTOR gene product; mTOR protein; malignancy; malignant breast neoplasm; mammalian target of rapamycin (mTOR); mammary; mammary cancer prevention; mammary tumor; mammary tumor prevention; neoplasm/cancer; obese; obese people; obese person; obese population; ontogeny; pathway; population based; pre-clinical; preclinical; preclinical study; prevent; preventing; programs; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health medicine (field); public health relevance; rac protein kinase; related to A and C-protein; research study; response; social role; transcription factor; tumor; weight control; wt gain","Exercise, Breast Cancer Prevention, and Mechanisms","  Investigations into the effects of physical activity (PA) on various aspects of carcinogenesis in human populations involve an effort to quantify a very heterogeneous set of PA exposures. While such efforts are difficult and many limitations are widely recognized, there is substantial evidence supporting the existence of an inverse relationship between PA and cancer incidence and cancer-related mortality. In a recently released 2008 NIH Report on Physical Activity and Health, which reviewed the world's literature on physical activity and health, it was concluded that the evidence is strong that a reduction in risk for breast cancer is associated with moderate to vigorous PA. Estimates of the affect size ranged from 20% - 80% reduction in risk from the majority of reported cohort studies and 20% - 70% from a number of population-based case-control studies. The expert panel concluded that the risk reduction is likely to range from 20 to 40%, and that there are direct effects of PA on breast cancer that are distinct from the effects of PA associated with weight control. Many experts contend that a primary factor that accounts for the global epidemic of overweight and obesity is physical inactivity. This leads to the public health recommendation that individuals should increase their level of PA. However, the focus on PA to control weight gain, while critical, tends to distract attention from the fact that 40% of women are an appropriate weight for their height. Importantly, for those individuals who are maintaining body weight in an acceptable range for cancer risk reduction, but who also wish to exercise for further reduction in risk, the relative importance of exercise intensity, duration, and frequency for cancer prevention is unclear and requires investigation. The work proposed in this project specifically addresses this population of women. As noted in the recently released NIH report on Physical Activity and Health, key translational questions remain unanswered about the intensity and duration of PA that prevent and control cancer and the nature of the dose response is unclear. Given evidence that breast cancer mortality also appears to be decreased by PA and that physical activity is increasingly being recommended during and after cancer treatment, work also is proposed to inform understanding of how PA affects the growth of established breast tumors and to identify the molecular characteristics of the breast cancers that PA affects. The proposed pre-clinical experiments address gaps in our knowledge about PA and cancer identified in the 2008 NIH Report on Physical Activity and Health. The data obtained has the potential to facilitate the translation of pre-clinical and clinical research to public health guidelines for PA directed to cancer prevention and control.",100693,CDP,Chemo/Dietary Prevention Study Section,,6,235445,
7758692,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA100835-07,,NCI:287346;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"OLDHAM, MARK ;",7136310;,5R01CA100835,04/01/2003,12/31/2012,"3-D; 3-Dimensional; Address; Agreement; Artifacts; Arts; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancer Radiotherapy; Cancers; Chest; Clinic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Credentialing; Data; Detection; Dose; Drug Formulations; EMI scan; Environment; Equilibrium; FLR; Failure (biologic function); Film; Formulation; Formulations, Drug; Future; H+ element; Head and Neck; Head and neck structure; Hydrogen Ions; IMRT; Image; Institution; Intensity Modulated RT; Intensity Modulated Radiation Therapy; Intensity-Modulated Radiotherapy; Investigation; Malignant Neoplasms; Malignant Tumor; Methods and Techniques; Methods, Other; Metric; Modality; Morphologic artifacts; Noise; Octopus; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Patients; Pattern; Pelvic; Pelvic Region; Pelvis; Physics; Plant Roots; Protons; Radiation; Radiation therapy; Radiation, Visible; Radiation, Visible Light; Radiotherapeutics; Radiotherapy; Relative; Relative (related person); Reporting; Research; Resolution; Scanning; Source; Speed; Speed (motion); Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Technology; Testing; Thorace; Thoracic; Thorax; Time; Tomodensitometry; Tomography, Xray Computed; Visible Light; Visible Radiation; X-Ray Computed Tomography; balance; balance function; catscan; clinical applicability; clinical application; clinical investigation; clinical research site; clinical site; cohort; computed axial tomography; computerized axial tomography; computerized tomography; dosimetry; experience; failure; imaging; improved; innovate; innovation; innovative; irradiation; light scattering; malignancy; neoplasm/cancer; novel; ray (radiation); response; root; success; surgery; usability","Accurate, High Resolution 3D Dosimetry",,100835,RTB,Radiation Therapeutics and Biology Study Section,,7,287346,
7803597,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA101850-06,,NCI:271181;,2010,NATIONAL CANCER INSTITUTE,,SALT LAKE CITY,UNITED STATES,PHARMACOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"BAE, YOU HAN;",1959690;,5R01CA101850,07/01/2003,01/31/2014,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 3-D; 3-Dimensional; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; Adriamycine; Animal Model; Animal Models and Related Studies; Animals; Anzatax; Asotax; Behavior; Blood Vessel Tumor; Body Tissues; Bone Marrow; Breast; Bristaxol; Cancer of Breast; Cancer of the Ovary; Cancers; Cell Communication; Cell Interaction; Cell Line; Cell Lines, Strains; Cell-to-Cell Interaction; CellLine; Cells; Clinical; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerase II; DNA Topoisomerases, Type II; DNA Type 2 Topoisomerase; DOX; Defense Mechanisms; Development; Disease; Disorder; Dorsal; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; Doxorubicin; Doxorubicina; Drug Carriers; Drug Formulations; Drug Kinetics; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug-sensitive; Drugs; Effectiveness; Endosomes; Engineering; Engineerings; Evaluation; Event; Exocytosis; Folate; Formulation; Formulations, Drug; Freeze Drying; Freeze Dryings; Funding; Future; Goals; Heart; Histopathology; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; In Vitro; Investigation; Killings; Kinetic; Kinetics; Link; Liver; Lyophilization; Lytotoxicity; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Malignant Cell; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Ovary; Malignant neoplasm of breast; Malignant neoplasm of ovary; Mammals, Mice; Medication; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Micelles; Modeling; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Neoplasm Metastasis; Neoplasms in Vascular Tissue; Ovarian Tumor; Ovary Neoplasms; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phase; Polymers; Powder dose form; Powders; Praxel; Procedures; Process; Production; Receptosomes; Regimen; Research; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Reticuloendothelial System, Bone Marrow; Secondary Neoplasm; Secondary Tumor; Skin; Solid; Solid Neoplasm; Solid Tumor; Solutions; System; System, LOINC Axis 4; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Therapeutic; Tissue Model; Tissues; Topo II; Topoisomerase II; Toxic effect; Toxicities; Tumor Cell; Tumor Cell Migration; Tumor of the Ovary; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; blood vessel neoplasm; body system, hepatic; cancer cell; cancer metastasis; chemotherapeutic agent; clinical applicability; clinical application; clinical relevance; clinically relevant; copolymer; cultured cell line; cytotoxic; cytotoxicity; cytotoxicity test; disease/disorder; drug distribution; drug/agent; efficacy evaluation; efflux pump; folate carrier; folate receptor; folate-binding protein; folate-methotrexate transporter; folic acid binding protein; folic acid receptor; in vitro Model; in vivo; intervention development; malignancy; malignant breast neoplasm; membrane structure; methotrexate-binding protein; model organism; mouse model; multi-drug resistant; multidrug resistant; neoplasm/cancer; neoplastic cell; organ system, hepatic; ovarian cancer; ovarian neoplasm; overexpression; pathway; poly(L-histidine); poly-L-lactic acid; pre-clinical; preclinical; preclinical study; psychological defense mechanism; public health relevance; receptor mediated endocytosis; reconstitute; reconstitution; resistance mechanism; resistant; resistant mechanism; scale up; therapy development; translational study; treatment development; tumor; tumor xenograft",ENGINEERED INTELLIGENT MICELLE FOR TUMOR pH TARGETING," PROJECT NARRATIVE Unique pH-sensitive micelle/doxorubicin formulations tested in current funding period were found to be effective in tumor accumulation and killing various sensitive and multidrug resistant tumor cells in vitro and in in vivo animal models . The research finalized a most effective formulation from animal studies along with systemic PK ananlysis. The results obtained strongly support the potential of preclinical investigation for future translational study. This competing renewal application thus proposes to develop the scale-up processes of polymers and micelles as well as a new micelle/paclitaxel formualtion. Paclitaxel is a frontline chemotherapeutic for breast and ovarian cancers which are current target diseases of the preclinical investigation. The preclinical study will include development of a powder formulation for storage, stability studies of the drug-loaded micelles in powder and in solution, toxicological evaluation, and an efficacy study. The research also plans to investigate more multidrug resistant models relevant to clinical setting and pharmacokinetic analysis at cellular and tissue levels.",101850,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,6,271181,
7795189,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA101963-07,,NCI:614346;,2010,NATIONAL CANCER INSTITUTE,,KANSAS CITY,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"ELLERBECK, EDWARD F;",1890800;,5R01CA101963,07/09/2003,01/31/2014,"2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; Abstinence; Active Follow-up; Arm; Attention; Caring; Cessation of Treatment; Cessation of smoking; Cigarette; Communication; Communities; Cotinine; Counseling; Disease Management; Disorder Management; Drug Therapy; Drugs; Effectiveness; Elements; Fax; Foundations; Goals; HOSP; Health Care Providers; Health Care Team; Health Personnel; Healthcare Providers; Healthcare Team; Healthcare worker; Hospitalization; Hospitals; Hospitals, Rural; Human Resources; Inpatients; Insurance; Insurance Coverage; Insurance Status; Kansas; Lead; Link; Manpower; Mediating; Medical Care Team; Medication; Modeling; Outcome; Participant; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phone; Population; Position; Positioning Attribute; Preparedness; Prevalence; Programs (PT); Programs [Publication Type]; Randomized; Readiness; Recommendation; Recruitment Activity; Relapse; Research; Research Resources; Resources; Rural; Rural Community; Rural Health; Rural Hospitals; Salivary; Scotine; Screening procedure; Smoke; Smoker; Smoking; Specialist; Staging; Study of Disease Management; Suggestion; Telefacsimile; Telefax; Telephone; Testing; Time; Tobacco; Tobacco Consumption; Tobacco use; Upper arm; Withholding Treatment; Work; base; cease smoking; chronic care model; cost effectiveness; critical access hospital; design; designing; disease management study; drug/agent; effective therapy; expectation; experience; follow-up; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; high risk; improved; innovate; innovation; innovative; medical personnel; multidisciplinary; personnel; primary outcome; programs; public health relevance; randomisation; randomization; randomly assigned; recruit; screening; screenings; smoking cessation; treatment provider",Centralized Disease Management for Rural Hospitalized Smokers," Project Narrative Many hospitalized smokers do not receive effective smoking cessation treatment. In this follow-up to Kan Quit we will see if disease management for hospitalized smokers can increase use of effective pharmaco- therapy, improve communication with health care providers, and increase rates of smoking cessation.",101963,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,7,614346,
7802935,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA102365-07,,NCI:317129;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"VASIOUKHIN, VALERI ;",7036258;,5R01CA102365,07/01/2003,02/28/2014,"2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; 3-D; 3-Dimensional; Adhesions; Adverse effects; Affect; Antihyperlipemics; Antihyperlipidemics; Antilipemic Agents; Antilipemic Drugs; Antilipemics; Attenuated; Autoregulation; Award; Basement membrane; Benign; Bioavailability; Bioavailable; Biologic Availability; Biological Availability; Blood Plasma; Body Tissues; Bone Metastasis; Bone cancer metastatic; Bony metastasis; Cancer Patient; Cancer of Prostate; Cancers; Carcinoma of prostate; Cell Adhesion; Cell surface; Cells; Cellular Adhesion; Cessation of life; Cleaved cell; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Death; Development; Disease; Disorder; Drug Kinetics; Drugs; Enzymes; Epithelium; Essential Genes; Esteroproteases; Extracellular Matrix Proteins; Food; Future; Generations; Genes; Genes, Essential; Genetic; Genital System, Male, Prostate; High Throughput Assay; Homeostasis; Human; Human Prostate; Human Prostate Gland; Human, General; Hydrogen Oxide; IC50; In Vitro; Inhibitory Concentration 50; Intervention; Intervention Strategies; Lead; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Metastasis; Metastasis to bone; Metastasize; Metastatic Cancer to the Bone; Metastatic Neoplasm; Metastatic Neoplasm to the Bone; Metastatic Prostate Cancer; Metastatic Tumor; Metastatic Tumor to the Bone; Metastatic malignant neoplasm to bone; Mice; Modification; Motion Sickness; Murine; Mus; Neoplasm Metastasis; Operation; Operative Procedures; Operative Surgical Procedures; Osseous metastasis; Pathway interactions; Patient observation; Patients; Pb element; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacokinetics; Pharmacologic Substance; Pharmacological Substance; Phenol, 4,4'-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl))-; Physiologic Availability; Physiological Homeostasis; Plasma; Play; Prevention; Probucol; Property; Property, LOINC Axis 2; Prostate; Prostate CA; Prostate Cancer; Prostate Carcinoma Metastatic; Prostate Gland; Prostate Neoplasms; Prostate carcinoma; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Prostatic carcinoma; Proteases; Proteinases; Proteolytic Enzymes; Regulation; Reticuloendothelial System, Serum, Plasma; Role; Secondary Neoplasm; Secondary Tumor; Secondary cancer of bone; Secondary malignancy of bone; Secondary malignant neoplasm of bone; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Serum, Plasma; Skeletal metastasis; Specificity; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Tissues; Toxic effect; Toxicities; Travel Sickness; Treatment Side Effects; Tumor Cell Migration; Tumor of the Prostate; Watchful Waiting; Water; Work; abstracting; antihyperlipoproteinemic agent; attenuation; bioavailability of drug; bone neoplasm secondary; cancer metastasis; cancer progression; cleaved; cohort; compound-1; disease/disorder; dosage; drug/agent; extracellular; heavy metal Pb; heavy metal lead; hepsin; high throughput screening; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; interventional strategy; malignancy; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; overexpression; pathway; prevent; preventing; pro-HGF; pro-hepatocyte growth factor; proHGF; prostatic cancer, carcinoma; public health relevance; side effect; small molecule; social role; surgery; therapy adverse effect; treatment adverse effect; tumor; tumor progression",Invasion and Metastasis in Prostate Cancer," ABSTRACT Hepsin is one of the most upregulated genes in human prostate cancer. It is overexpressed in up to 90% of primary prostate tumors with levels often increased >10 fold. Hepsin encodes a cell-surface serine protease that can activate the uPA proteolytic system and the HGF-MET cell scattering and invasion pathway. Overexpression of hepsin plays causal role in prostate cancer and promotes prostate cancer progression and metastasis. We hypothesize that pharmaceutical inhibition of hepsin's proteolytic activity will result in attenuation of prostate cancer progression and metastasis. In this case, small molecule hepsin inhibitors could prove to be very useful for treating the `watchful waiting' cohort of prostate cancer patients, to attenuate or inhibit primary cancer progression and, potentially, eliminate the need for surgical or radiological intervention in these patients. The major objective of this study is to develop small molecule hepsin inhibitors, analyze their pharmacokinetic properties and determine their efficacy in attenuation of prostate cancer progression in mouse models of metastatic prostate cancer. This study is developing a novel treatment approach and a novel therapeutic target for attenuation or prevention of metastatic prostate cancer.",102365,TPM,Tumor Progression and Metastasis Study Section,,7,317129,
7789631,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA102514-07,,NCI:332920;,2010,NATIONAL CANCER INSTITUTE,,AURORA,UNITED STATES,PHARMACOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"AGARWAL, RAJESH ;",1869349;,5R01CA102514,07/09/2003,01/31/2014,"Adenocarcinoma; Adenoma, Malignant; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Animals; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Applications Grants; Bone; Bone Metastasis; Bone and Bones; Bone cancer metastatic; Bones and Bone Tissue; Bony metastasis; Cancer Cause; Cancer Cell Growth; Cancer Etiology; Cancer Patient; Cancer of Prostate; Cancers; Carduus marianus; Cell Culture System; Cell Culture Techniques; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Clinic; Clinical Trials, Phase I; Clinical Trials, Phase II; Death; Development; Diagnosis; Diet Supplement; Dietary Supplements; Disease; Disorder; Distant; Distant Cancer; Distant Metastasis; Early-Stage Clinical Trials; Endothelial Cells; Epithelial; Event; Fibroblasts; Funding; Generalized Growth; Genital System, Male, Prostate; Grant; Grant Proposals; Grants, Applications; Growth; Hepatoprotectants; Hepatoprotective Agent; Hepatoprotective Drugs; Human; Human Prostate; Human Prostate Gland; Human, General; Hypoxia; Hypoxic; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intermediary Metabolism; Lesion; Lung; METBL; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mesenchymal; Metabolic Processes; Metabolism; Metastasis; Metastasis to bone; Metastasize; Metastatic Cancer to the Bone; Metastatic Neoplasm; Metastatic Neoplasm to the Bone; Metastatic Tumor; Metastatic Tumor to the Bone; Metastatic malignant neoplasm to bone; Mice; Milk Thistle; Molecular; Murine; Mus; Neoplasm Metastasis; Neovascularization Inhibitors; Nutritional Supplement; Oral; Osseous metastasis; Osteoblasts; Osteoclasts; Outcome; Oxygen Deficiency; Phase 1 Clinical Trials; Phase 2 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phase II Clinical Trials; Plant Embryos; Pre-Clinical Model; Preclinical Models; Prevention; Prevention of Prostate CA; Prevention of Prostate Cancer; Preventive; Process; Prostate; Prostate CA; Prostate CA Prevention; Prostate CA therapy; Prostate Cancer; Prostate Cancer Prevention; Prostate Cancer therapy; Prostate Gland; Prostatic Cancer; Prostatic Gland; Public Health; Research; Respiratory System, Lung; SCID; SCID Mice; Secondary Neoplasm; Secondary Tumor; Secondary cancer of bone; Secondary malignancy of bone; Secondary malignant neoplasm of bone; Secondary to; Seeds; Severe Combined Immunodeficient Mice; Silybum marianum; Site; Skeletal metastasis; Testing; Therapeutic Intervention; Time; Tissue Growth; Toxic effect; Toxicities; Transgenic Organisms; Treatment Efficacy; Tumor Angiogenesis; Tumor Cell; Tumor Cell Migration; Tumor Tissue; United States; Work; Xenograft Model; Zygotes, Plant; abstracting; angiogenesis; antiangiogenic; anticarcinogenic; base; bone; bone neoplasm secondary; cancer cell; cancer metastasis; cancer progression; disease/disorder; epithelial to mesenchymal transition; in vivo; intervention therapy; malignancy; men; men's; migration; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; ontogeny; phase 1 study; phase 1 trial; phase 2 study; phase 2 trial; phase I trial; phase II trial; pre-clinical; preclinical; prostate cancer prevention; protocol, phase I; protocol, phase II; public health medicine (field); public health relevance; pulmonary; seed; severe combined immune deficiency; silibin; silibinin; silybin; study, phase II; therapeutic efficacy; therapeutically effective; tissue/cell culture; tool; transgenic; tumor; tumor growth; tumor progression",Prostate Cancer Prevention and Treatment by Silibinin," Project Narrative Prostate cancer is second leading cause of cancer-related deaths in United States, and thus is an important public health issue. Use of chemopreventive agents seems to be more effective approach for the control of prostate cancer as it has long latent period of development; sometimes over decade from precursor lesions to full blown disease. Current grant proposal focuses on the development of one such agent, namely silibinin, which is already consumed extensively in the United States and world-wide as a dietary supplement and used in the clinic as a hepatoprotective agent. This compound has not shown any toxicity in animal studies as well as in humans. The outcomes of our proposed research will provide a mechanism-based agent for the prevention and therapeutic intervention of prostate cancer in humans.",102514,CDP,Chemo/Dietary Prevention Study Section,,7,332920,
7758228,R01,CA,5,,02/01/2010,01/31/2011,PA-97-053,5R01CA104025-05,,NCI:258530;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,BIOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"FEITELSON, MARK A;",1865061;,5R01CA104025,02/06/2006,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; ATGN; Address; Adenoviridae; Adenoviruses; Agar; Alleles; Allelomorphs; Anchorage-Independent Growth; Antigens; Apoptosis; Apoptosis Pathway; Assay; Athymic Nude Mouse; BUdR; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Blotting, Western; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CAM 120/80; CTNNB1; CUL-2; Cadherin-1; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancers; Carcinoma of the Liver Cells; Catenin, Beta-1; Cell Communication and Signaling; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chemoprevention; Chronic; Critical Paths; Critical Pathways; Cytofluorometry, Flow; DNA Replication; DNA Synthesis; DNA biosynthesis; Data; Depressed mood; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; E-Cadherin; EC 2.7; Epithelial; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Exons; Figs; Figs - dietary; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gene Targeting; Generalized Growth; Genes; Glycogen Synthase Kinases; Growth; HBV; HBV X protein; HBxAg; HCC; Half-Life; Half-Lifes; Harvest; Health Benefit; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatitis B Virus; Hepatitis B Virus-X; Hepatitis B X-Protein; Hepatitis Virus, Homologous Serum; Hepatoblastoma; Hepatocarcinogenesis; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Human; Human, General; In Situ Nick-End Labeling; Individual; Intracellular Communication and Signaling; Investigators; Kinases; Liver; Liver Carcinogenesis; Liver Cells; Liver diseases; Liver neoplasms; Macropain; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Messenger RNA; Mice; Mice, Athymic; Mice, Nude; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Microfluorometry, Flow; Molecular; Multicatalytic Proteinase; Murine; Mus; Neoplasms, Hepatic; Nuclear; Nude Mice; Oncogenesis; PRO2286; Partner in relationship; Pathogenesis; Patients; Pediatric Embryonal Hepatoma; Pediatric Hepatoblastoma; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Primary carcinoma of the liver cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteins; Proteosome; Public Health; RNA, Messenger; Recombinants; Research; Research Personnel; Researchers; Run-On Assays; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stability, mRNA; Staining method; Stainings; Stains; TUNEL; Targetings, Gene; Testing; Therapeutic Intervention; Time; Tissue Growth; Transgenic Mice; Transphosphorylases; Treatment outcome; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uridine, 5-bromo-2'-deoxy-; Uvomorulin; Western Blotting; Western Blottings; Western Immunoblotting; Work; base; beta catenin; biological signal transduction; body system, hepatic; carcinogenesis in the liver; cultured cell line; depressed; drug/agent; experiment; experimental research; experimental study; flow cytophotometry; gene product; hepatic neoplasia; hepatic neoplasm; hepatitis B virus X antigen; hepatitis B virus X protein; hepatocellular carcinogenesis; hepatopathy; immunogen; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; liver cancer pathogenesis; liver disorder; liver tumor; mRNA; mRNA Stability; malignancy; mate; microarray technology; multicatalytic endopeptidase complex; mutant; neoplasm/cancer; offspring; ontogeny; organ system, hepatic; protein blotting; public health medicine (field); recombinase; research study; sadness; terminal nick end labeling; therapeutic target; transcriptional transactivator hbx; tumor; tumorigenesis; vector",Beta-Catenin Signaling in HBxAg Mediated HCC.,,104025,CE,Cancer Etiology Study Section,,5,258530,
7763810,R01,CA,5,,02/01/2010,01/31/2011,PAR-03-009,5R01CA105048-05,,NCI:313716;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"ARAB, LENORE ;",1889237;,5R01CA105048,06/28/2006,01/31/2011,"21+ years old; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol; 3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12- trimethyltridecyl)-2H-1-benzopyran-6-ol.; Adopted; Adult; African American; Afro American; Afroamerican; Age; Au element; Benzoic Acids; Biologic Marker; Biological; Biological Markers; Black Populations; Black or African American; Blood; Caloric Intake; Carotenes and Carotenoids; Carotenoids; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communication; Communities; Complex; Computer Assisted; Computer Programs; Computer Systems; Computer software; Consumption; Counseling; Data; Diet; Diet Habits; Diet Supplement; Dietary Assessment; Dietary Potassium; Dietary Supplements; Dietary intake; Eating; Editorial Comment; Editorial Comment (PT); Education; Educational aspects; Energy Expenditure; Energy Intake; Energy Metabolism; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethnic group; Feedback; Food; Food Intake; Frequencies (time pattern); Frequency; Funding; Goals; Gold; Habits, Dietary; History; Hour; Human, Adult; Hydrogen Oxide; Image; Immune; Individual; Individual Differences; Intake; Internet; Interview; Investigators; K element; Label; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Marker; Multimedia; Multimedium; N element; N2 element; Nitrogen; Nutrient; Nutrition; Nutritional; Nutritional Science; Nutritional Supplement; Occidental; On-Line Systems; Online Systems; Patient Self-Report; Personal Computers; Persons; Physical activity; Population; Potassium; Potassium, Dietary; Proteins; Published Comment; Questionnaires; RFP; Recording of previous events; Records; Recovery; Reliance; Reproducibility; Request for Proposals; Research; Research Design; Research Personnel; Researchers; Reticuloendothelial System, Blood; Sampling; Science of nutrition; Scientist; Self-Administered; Self-Report; Signature Molecule; Software; Structure; Study Type; System; System, LOINC Axis 4; Techniques; Testing; Time; Tocopherols; Validation; Viewpoint; Viewpoint (PT); Vitamin E; WWW; Water; adult human (21+); alpha Tocopherol; base; biomarker; black American; caloric dietary content; computer aided; computer program/software; cost; d-alpha-Tocopherol; design; designing; eating habit; fruits and vegetables; gamma-Tocopherol; gene product; imaging; instrument; nutrient blood level; nutrition; online computer; study design; tool; urinary; validation studies; web; web based; white race; world wide web",Validation of Web-based Multimedia Dietary Assessment Tools,,105048,ZRG1,Special Emphasis Panel,,5,313716,
7755871,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA106416-05,,NCI:419081;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"LEES, JACQUELINE A.;",1968422;,5R01CA106416,03/07/2006,01/31/2011,"Accounting; Address; Aging; Anti-Oncogenes; Antioncogene Protein p53; Antioncogenes; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Brachydanio rerio; Cancer Genes; Cancer Model; Cancer Syndromes, Hereditary; Cancer-Promoting Gene; CancerModel; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Tumor Antigen P53; Central Neurofibromatosis; Collection; Danio rerio; Data; Defect; Development; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Emerogenes; Familiar Neoplastic Syndrome; Fishes; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Suppressor; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Hereditary Neoplastic Syndromes; Heterozygote; Individual; Insertional Mutagenesis; Intracellular Communication and Signaling; Investigators; Laboratories; Lead; Life; Link; Literature; MPNST; Malignant Neoplasms; Malignant Peripheral Nerve Sheath Tumor; Malignant Schwannoma; Malignant Tumor; Mammalia; Mammalian Cell; Mammals; Mammals, General; Modeling; Molecular; Mutagenesis, Insertional; Mutate; Mutation; Nature; Neoplastic Syndromes, Hereditary; Neurofibromatosis 2; Neurofibromatosis II; Neurofibromatosis, Acoustic, Bilateral; Neurofibromatosis, Central, NF 2; Neurofibromatosis, Central, NF2; Neurofibromatosis, Type 2; Neurofibromatosis, Type II; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncoprotein p53; Ortholog; Orthologous Gene; P53; Pathway interactions; Pb element; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Play; Polyribosomes; Polysomes; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein TP53; Protein p53; Proteins; Regulation; Research Personnel; Research Resources; Researchers; Resources; Ribosomal Proteins; Ribosomes; Role; Second-Site Suppressor Genes; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Suppressor Genes; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Transforming Genes; Translations; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Type 2s, Neurofibromatosis; Zebra Danio; Zebra Fish; Zebrafish; acoustic neurofibromatosis; base; biological signal transduction; experiment; experimental research; experimental study; gene function; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; insight; malignancy; mutant; neoplasm/cancer; neuronal tumor; oncosuppressor gene; ontogeny; p53 Antigen; p53 Tumor Suppressor; pathway; programs; research study; senescent; social role; tumor; tumor suppressor; tumorigenic",Using Zebrafish to Identify and Analyze Cancer Genes,,106416,CAMP,Cancer Molecular Pathobiology Study Section,,5,419081,
7768437,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA107070-07,,NCI:271181;,2010,NATIONAL CANCER INSTITUTE,,SALT LAKE CITY,UNITED STATES,PHARMACOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"KIM, SUNG WAN ;",1868468;,5R01CA107070,04/01/2004,01/31/2014,"2,2'-Dithiobisethanamine; 21+ years old; AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adenocarcinoma Cell; Adenocarcinoma, Renal Cell; Adult; Age related macular degeneration; Amides; Amines; Amyloid A4 Protein Precursor; Amyloid Protein Precursor; Amyloid beta-Protein Precursor; Analysis, Gel Shift; Animal Model; Animal Models and Related Studies; Animals; Anti-Angiogenesis; Anti-Sense Oligonucleotides; Antiangiogenesis; Antisense Agent; Antisense Oligonucleotides; Arg-Gly-Asp; Arginine; Arginine, L-Isomer; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain; Assay; Autoimmune Diseases; Azacyclopropanes; Azacyclopropanes, Saturated; Aziridines; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biotechnology; Blood Serum; Breast Adenocarcinoma; Buffers; Cancer Patient; Cancers; Carcinoma, Hypernephroid; Cell Culture Techniques; Cell Line; Cell Lines, Strains; CellLine; Cells; Characteristics; Clinic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Co-Stimulator; Complex; Costimulator; Cuprozinc Superoxide Dismutase; Cystamine; Cysteinamine Disulfide; Cystineamine; Cytofluorometry, Flow; Data; Decarboxycystine; Dermal; Dimethyleneimines; Disease; Disorder; Disulfides; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Effectiveness; Endocytosis; Endothelial Cells; Endothelium; Environment; Epidermal Thymocyte Activating Factor; Esters; Ethanamine, 2,2'-dithiobis-; Ethyleneimines; Ethylenimine Compound; Extracellular Matrix, Integrins; Eye Infections, Viral; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence Microscopy; Gel Retardation Assay; Gel Shift Analyses; Gelshift Analysis; Gene Delivery; Gene Expression; Gene Expression Inhibitor; Gene Inactivation; Gene Silencing; Gene Targeting; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Genital System, Male, Prostate; Genome, Human; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Grawitz Tumor; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Human; Human Genome; Human Immunodeficiency Viruses; Human Prostate; Human Prostate Gland; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, Adult; Human, General; Hydrogen Oxide; Hypernephroma; IL-2; IL2; IL2 Protein; Immunodeficiency Virus Type 1, Human; In Vitro; Integrin Binding; Integrins; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intervention, Genetic; Intracellular Space; Intravenous; Kinetic; Kinetics; L-Arginine; LAV-HTLV-III; Laboratories; Libraries; Lipids; Literature; Lymphadenopathy-Associated Virus; Lymphocyte Mitogenic Factor; Macrogols; Maculopathy, Age-Related; Malignant Glandular Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary adenocarcinoma; Man (Taxonomy); Man, Modern; Measurement; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Microfluorometry, Flow; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitogenic Factor; Modeling; Molecular Biology, Gene Therapy; Molecular Interaction; Murine; Mus; Nature; Neoplasm Metastasis; Nephroid Carcinoma; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Nucleic Acids; Ocular Infections, Viral; Oligo; Oligonucleotides; Oligonucleotides, Antisense; Oligopeptides; Oxidation-Reduction; PEG; Peptides; Phage Display; Pharmaceutics; Pharmacy (field); Phase; Physical condensation; Plasmids; Polyamine Compound; Polyamines; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polymers; Polyoxyethylenes; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevention; Primary Neoplasm; Primary Tumor; Process; Prostate; Prostate Gland; Prostatic Gland; Publishing; Quelling; RGD; RGD (peptide); RGD (sequence); RGD Cell Adhesion Domain; RGD Domain; RGD Motif; RGD Tripeptide Sequence; RGD tripeptide; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Receptor Protein; Redox; Renal Adenocarcinoma; Renal Cell Cancer; Renal Cell Carcinoma; Renal Cell Carcinoma, Stage Unspecified; Reporting; Safety; Screening procedure; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Site; Small Interfering RNA; Specificity; Structure; Superoxide Dismutase, Cu-Zn; Surface Plasmon Resonance; Survival Rate; System; System, LOINC Axis 4; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; Targetings, Gene; Therapeutic; Therapy, DNA; Thymocyte Stimulating Factor; Toxic effect; Toxicities; Transfection; Translations; Tumor Cell Migration; VEGF Receptors; VEGFR; VEGFs; VPF Receptor; Vascular Endothelial Cell; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vegf; Viral; Viral Eye Infections; Virus-HIV; Visual Acuity; WSLP cpd; Water; abstracting; adenocarcinoma of kidney; adult human (21+); amyloid precursor protein; angiogenesis; antiangiogenesis therapy; aqueous; arginyl-glycyl-aspartic acid; autoimmune disorder; base; cancer metastasis; cell fixing; clinical investigation; condensation; copolymer; cultured cell line; design; designing; disease/disorder; disulfide bond; experiment; experimental research; experimental study; extracellular; flow cytophotometry; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene therapy; genetic therapy; human T cell leukemia virus III; human T lymphotropic virus III; human disease; improved; in vivo; innovate; innovation; innovative; malignancy; model organism; monomer; nano particle; nanoparticle; neoplasm/cancer; nervous system disorder; neurological disease; non-viral gene delivery; nonviral gene delivery; novel; oxidation reduction reaction; peptidomimetics; poly(ethylenimine)-co-(N-(2-aminoethyl) ethyleneimin)-co-N-(N-cholesteryloxycarbonyl-(2-aminoethyl)ethylenimine); polycation; pre-clinical; preclinical; public health relevance; receptor; research study; screening; screenings; senile macular disease; siRNA; therapeutic gene; transfer of a gene; tumor; tumor growth; uptake; vector; water-soluble lipopolymer; zeta potential",RGD-POLYMER TARGETING PLASMID TO ANGIOGENIC ENDOTHELIUM," 7. PROJECT NARRATIVE  Three newly designed polymers will be conjugated with RGD. It is expected that both in vitro and in vivo studies will present positive results for siRNA delivery, which can be applied to tumor treatment.",107070,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,7,271181,
7771755,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA107476-07,,NCI:302516;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","RAJKUMAR, S VINCENT;",6196232;,5R01CA107476,03/01/2004,01/31/2014,"2,6-Dioxo-3-phthalimidopiperidine; 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 3-Phthalimidoglutarimide; Active Follow-up; Address; Affect; Age; Alpha-Phthalimidoglutarimide; Anemia; Architecture; Archives; Assay; Bioassay; Biologic Assays; Biological Assay; Blood; Blood Plasma Cell; Blood Sample; Blood Serum; Blood specimen; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancerous; Cancers; Causality; Cells; Clinic; Clinical; Clinical Trials Design; Coin; Collection; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Country; County; Coupled; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deuterium Oxide; Diagnosis; Disease; Disorder; EMI scan; Engineering / Architecture; Environment; Environmental Exposure; Environmental Factor; Environmental Risk Factor; Epidemiology; Equilibrium; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Etiology; Event; Family; Family member; First Degree Relative; Forecast of outcome; Funding; Future; General Population; General Public; Genes; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Goals; Grant; Health; Heavy Water; Heavy-Chain Immunoglobulins; Hereditary; High Resolution Computed Tomography; Hispanic Populations; Hispanics; Hispanics or Latinos; Human; Human, General; Hypercalcemia; IL-1 beta; IL-1-b; IL1-Beta; IL1B Protein; IL1F2; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; Immunoglobulins, Heavy-Chain; Immunoglobulins, Light-Chain; Individual; Infection; Inherited; Inherited Predisposition; Inherited Susceptibility; Institution; Interleukin 1, Beta Proprotein; Interleukin 1beta; Interleukin-1 beta; Intervention; Intervention Strategies; Kidney Failure; Kidney Insufficiency; Label; Laboratories; Latino Population; Lesion; Life; Life Style; Lifestyle; Lifestyle Factors, Unspecified; Light; Light-Chain Immunoglobulins; Link; Linkage (Genetics); Lytic; M Protein, multiple myeloma; M protein; MGUS; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Marrow; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Minnesota; Minority; Molecular Genetic; Molecular Genetics; Monoclonal Gammapathies; Monoclonal Gammopathies; Monoclonal Gammopathy of Undetermined Significance; Monoclonal Gammopathy of Unknown Significance; Monoclonal gammopathy of uncertain significance; Multiple Myeloma; Myeloma, Plasma-Cell; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; Natural History; Newly Diagnosed; Non-Hispanic; Non-Malignant; Not Hispanic or Latino; Nutritional; Obesity; Outcome; Pathogenesis; Patients; Peripheral; Photoradiation; Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-; Plasma Cells; Plasmacytes; Play; Population; Pre-Malignant; Precancerous Conditions; Predisposing Factor; Predisposition; Preinterleukin 1 Beta; Premalignant; Premalignant Condition; Premalignant State; Prevalence; Preventive; Preventive Intervention; Prognosis; Programs (PT); Programs [Publication Type]; Race; Racial Group; Recruitment Activity; Relative; Relative (related person); Renal Failure; Renal Insufficiency; Resolution; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Risk; Risk Factors; Role; Sampling; Scanning; Sedalis; Serum; Spanish Origin; Staging; Stocks, Racial; Survey Instrument; Surveys; Survival Rate; Susceptibility; Techniques; Testing; Thalidomide; Time; Tomodensitometry; Tomography, Xray Computed; Toxin; Tumor Cell; United States; Variant; Variation; Water-d2; X-Ray Computed Tomography; adiposity; balance; balance function; base; bone; catscan; clinical data repository; clinical data warehouse; cohort; computed axial tomography; computerized axial tomography; computerized tomography; corpulence; corpulency; corpulentia; data repository; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environmental risk; follow-up; genetic etiology; genetic linkage; genetic mechanism of disease; genetic vulnerability; hispanic community; improved; insight; interventional strategy; lifestyle factors; malignancy; member; multiple myeloma M Protein; myeloma; myelomatosis; neoplasm/cancer; neoplastic cell; nonmalignant; novel; obese; obese people; obese person; obese population; outcome forecast; plasmocyte; population based; precancerous; precancerous state; prevent; preventing; preventional intervention strategy; proband; programs; public health relevance; racial and ethnic; racial/ethnic; recruit; relational database; social role; trait",Prevalance and Progression of Monoclonal Gammopathies," Project Narrative Monoclonal gammopathy of undetermined significance (MGUS) is probably the most common pre-cancerous condition in the United States affecting over 3% of the population over the age of 50. The studies in this grant seek to answer a fundamental question as to what causes MGUS by studying carefully various racial and ethnic groups, as well as close family members. We also study why (and how) some but not all people with MGUS progress to the fatal cancer called multiple myeloma.",107476,CBSS,Cancer Biomarkers Study Section,,7,302516,
7804527,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA108420-07,,NCI:461278;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"SICINSKI, PIOTR ;",2278180;,5R01CA108420,04/19/2004,02/28/2014,"21+ years old; Ablation; Active Follow-up; Acute; Address; Adult; Animals; Antibodies; Avian Myelocytomatosis Viral Oncogene Homolog; Binding; Binding (Molecular Function); Blood Precursor Cell; Body Tissues; Brain; CCND1 Protein; Cancer Model; Cancer Patient; Cancer of Lung; CancerModel; Cancers; Cell Cycle; Cell Cycle Proteins; Cell Division Cycle; Cell Division Cycle Proteins; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell-Cycle Regulatory Proteins; Cells; Cellular Proliferation; Clinical; Cyclin D1; Cyclins; DNA Binding; DNA Binding Interaction; Development; Embryo; Embryonic; Embryonic Tissue; Encephalon; Encephalons; Environment; Fibroblasts; Funding; G1/S-Specific Cyclin D1; Gene Targeting; Genes; Gestation; Hematopoietic stem cells; Human; Human, Adult; Human, General; In Vitro; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knockout Mice; Link; Lymphocytes, Null; MYC; MYC gene; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Interaction; Mouse Strains; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Normal Cell; Null Cells; Null Lymphocytes; Null Mouse; Oncogenes, myc; Oncogenesis; Oncogenic; Organism; PRAD1 Protein; Phenotype; Play; Population; Predisposition; Pregnancy; Progenitor Cells, Hematopoietic; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proto-Oncogene Proteins c-bcl-1; Public Health; Pulmonary Cancer; Pulmonary malignant Neoplasm; Resistance; Role; Susceptibility; Targetings, Gene; Techniques; Testing; Time; Tissues; Work; adult animal; adult human (21+); bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; c-bcl-1 Proteins; cdc Proteins; cell transformation; cell type; cyclin D; embryo cell; embryo tissue; extracellular; follow-up; genome, mouse; in vivo; knockout animal; living system; lung cancer; malignancy; mature animal; mouse genome; neoplasm/cancer; neuronal; novel; overexpression; public health medicine (field); public health relevance; resistant; social role; therapeutic target; transcription factor; transformed cells; tumorigenesis",Analyses of the Molecular Functions for D-Cyclins," b. Project Narrative (Statement of relevance to public health) Overexpression of D-cyclins is seen in a very large fraction of human cancers. For this reason, D-cyclins are considered as potential therapeutic targets. This study will address two key issues that must be resolved before anti-cyclin D therapy in human cancer patients is entertained: (1) Are D-cyclins required for normal cell proliferation and function in the adult organism? (2) Would blocking cyclin D function in oncogenically transformed cells revert the oncogenic transformation?",108420,MONC,Molecular Oncogenesis Study Section,,7,461278,
7760156,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA108813-05,,NCI:278672;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,DERMATOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"YOU, ZHAOYANG ;",7120698;,5R01CA108813,03/01/2006,01/31/2011,"ATGN; Adjuvant; Antigens; Antineoplastic Vaccine; Attention; Avidity; Binding; Binding (Molecular Function); Bp50; CD40; CD8; CD8B; CD8B1; CD8B1 gene; CDW40; CMV promoter; Cancer Vaccines; Cancers; Cell Mediated Immunology; Cell Survival; Cell Viability; Cell-Mediated Immunity; Cellular Immunity; Chaperone; Chimera Protein; Chimeric Proteins; Clinical; DNA; DNA Vaccines; Dendritic Cells; Dendritic cell activation; Deoxyribonucleic Acid; Fusion Protein; Future; Genes; HSP; Heat shock proteins; ITX; Immune Tolerance; Immune response; Immunity; Immunity, Cellular; Immunization; Immunobiology; Immunologic Stimulation; Immunologic Tolerance; Immunological Stimulation; Immunologically Directed Therapy; Immunophysiology; Immunostimulation; Immunotherapy; Investigators; LYT3; Length of Life; Longevity; Lymphatic Tissue; Lymphoid Tissue; MGC9013; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Modeling; Molecular Chaperones; Molecular Interaction; Murine; Mus; Naked DNA Vaccines; Peptides; Play; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Receptor Protein; Receptor Signaling; Recombinants; Regulation; Research Personnel; Researchers; Role; Sensitization, Immunologic; Sensitization, Immunological; Stress Proteins; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TLR4; TLR4 gene; TNFRSF5; TNFRSF5 gene; TOLL; Testing; Thymus-Dependent Lymphocytes; Tumor Immunity; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Vaccination; Vaccine Design; Vaccines; Vaccines, DNA; Vaccines, Neoplasm; Vaccines, Recombinant DNA; Vaccines, Tumor; Veiled Cells; Work; base; gene product; hToll; host response; immune system tolerance; immune therapy; immune unresponsiveness; immunogen; immunogenic; immunogenicity; immunological paralysis; immunoresponse; improved; in vivo; insight; life span; lifespan; malignancy; melanoma; neoplasm/cancer; novel; p50; receptor; response; social role; thymus derived lymphocyte; tumor; uptake; vaccine efficacy",In Vivo Targeted Vaccines for Tumor Immunotherapy,,108813,CII,Cancer Immunopathology and Immunotherapy Study Section,,5,278672,
7758264,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA109106-05,,NCI:264562;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"GORE, JOHN C;",1894945;,5R01CA109106,03/15/2006,01/31/2011,"Affect; After Care; After-Treatment; Aftercare; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Behavior; Body Tissues; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Breast Neoplasms; Breast Tumors; Cancers; Cell Components; Cell Death, Programmed; Cell Density; Cell Growth/Cell Cycle; Cell Size; Cell Structure; Cells; Cellular Morphology; Cellular Structures; Cellularity; Characteristics; Computer Simulation; Computerized Models; Data; Data Set; Dataset; Density, Cell; Diffuse; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Drugs; Frequencies (time pattern); Frequency; HeLa; Hela Cells; Histology; Hydrogen Oxide; Image; Immunochemistry; In Vitro; M Phase; M phase (cell cycle); MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Methods; Methods and Techniques; Methods, Other; Mice; Micro-tubule; Microtubules; Mitosis; Mitosis Stage; Mitotic Cell Cycle; Modeling; Models, Computer; Monitor; Motivation; Murine; Mus; NMR Imaging; NMR Tomography; Nuclear; Nuclear Magnetic Resonance Imaging; Organelles; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Physiologic pulse; Pulse; Research; Simulation, Computer based; Structure; Surface; Suspension substance; Suspensions; System; System, LOINC Axis 4; Techniques; Time; Tissues; Tumor Cell; Variant; Variation; Water; Water Movements; Weight; Zeugmatography; base; cancer progression; cell morphology; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; density; diffusion tensor imaging; drug/agent; imaging; imaging modality; in silico; in vivo; in vivo Model; malignancy; mammary tumor; model organism; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new approaches; novel; novel approaches; novel strategies; novel strategy; oscillating gradient spin echo; response; suspension; time interval; tool; tumor; tumor growth; tumor progression; tumors in the brain; virtual simulation; water diffusion",MRI Diffusion in Tumors Using Oscillating Gradients,,109106,BMIT,Biomedical Imaging Technology Study Section,,5,264562,
7749957,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA109234-05,,NCI:456856;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"FREY, ERIC C.;",1898131;,5R01CA109234,03/01/2006,01/31/2011,"131-I-Anti-B1 Antibody; 131I anti-B1; Accounting; Adverse effects; Adverse reactions; Algorithms; Anatomic; Anatomic Models; Anatomical Sciences; Anatomy; Anti-CD20 Antibody; Arts; Biodistribution; Blood Vessels; Bone Marrow; Bone Marrow Neoplasms; Bone Marrow Tumor; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Collection; Collimation; Collimator; Compensation; Computer Programs; Computer software; Data; Development; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Dose; Drug Kinetics; Enrollment; Financial compensation; Goals; I 131 Monoclonal Antibody Anti-B1; I 131 Tositumomab; I131-MOAB-B1; Ibritumomab (In2B8/Y2B8 Radiolabeling Kit); Ibritumomab Tiuxetan; Image; Image Analyses; Image Analysis; Image Reconstructions; In2B8/Y2B8 Radiolabeling Kit (Ibritumomab tiuxetan, Zevalin); Incidence; Investigators; Iodine I 131 MOAB Anti-B1; Iodine I 131 Monoclonal Antibody Anti-B1; Iodine I 131 Tositumomab; Iodine-131 Anti-B1 Antibody; Iodine-131 Anti-CD20 Monoclonal Antibody; Isotopes; Kidney; Knowledge; Label; Laboratories; Lateral; Liver; Measures; Medical Imaging, Single Photon Emission Computed Tomography; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; MoAb Anti-B1; MoAb CD20; Modeling; Models, Anatomic; Models, Anatomical; Models, Statistical; Monoclonal Antibody Anti-B1; Monoclonal Antibody CD20; Normal Tissue; Normal tissue morphology; Organ; Organ Size; Patients; Penetration; Pharmacokinetics; Photons; Population; Position; Positioning Attribute; Probabilistic Models; Process; Protocol; Protocols documentation; ROC Analysis; Radioactive; Radioactivity; Radioimmunoconjugate; Radiolabeled Antibodies; Radionuclide Tomography, Single-Photon Emission-Computed; Radionuclide therapy; Radiopharmaceutical Compound; Radiopharmaceuticals; Reconstructions, Image; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Spleen; Role; SPECT; SPECT imaging; Scanning; Science of Anatomy; Shapes; Simulate; Software; Spleen; Statistical Distributions; Statistical Models; System; System, LOINC Axis 4; Techniques; Therapeutic; Therapeutic Effect; Therapeutic Trials; Therapy Clinical Trials; Time; Tomography, Emission-Computed, Single-Photon; Toxic effect; Toxicities; Treatment Side Effects; Urinary System, Kidney; Variant; Variation; Work; Y 90 Ibritumomab Tiuxetan; Yttrium Y 90 Ibritumomab Tiuxetan; Yttrium-90 Ibritumomab Tiuxetan; Zevalin; anatomy; anti-B1; attenuation; base; bexxar; body system, hepatic; clinical investigation; computer program/software; detector; dosimetry; enroll; image evaluation; imaging; imaging modality; improved; in vivo; insight; iodine-131 anti-B1 monoclonal antibody; iodine-131-labeled anti-CD20 antibody; iodine-131-tositumomab; organ system, hepatic; patient population; radioactive drugs; reconstruction; renal; residence; response; side effect; simulation; social role; therapy adverse effect; tositumomab; treatment adverse effect; treatment planning; tumor; uptake; vascular; yttrium Y90 ibritumomab tiuxetan",Quantitative SPECT for Targeted Radionuclide Therapy,,109234,BMIT,Biomedical Imaging Technology Study Section,,5,456856,
7746419,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA109460-05,,NCI:227246;,2010,NATIONAL CANCER INSTITUTE,,MORGANTOWN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,191510239,US,WV,265066845,WEST VIRGINIA UNIVERSITY,"JIANG, BING-HUA ;",2119871;,5R01CA109460,02/01/2006,12/31/2010,"AKT; AKT inhibition; Affect; Akt protein; Angiosarcoma; Antimorphic mutation; Autocrine Systems; BZS; Cancer of Prostate; Cell Communication and Signaling; Cell Signaling; Cells; Cultured Cells; DNA Alteration; DNA mutation; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Endothelial Cells; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Future; Gene Alteration; Gene Mutation; Genetic mutation; Genital System, Male, Prostate; Goals; Hemangiosarcoma; Human; Human Prostate; Human Prostate Gland; Human, General; Intracellular Communication and Signaling; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Link; MDM 2; MDM2; MDM2 gene; MHAM; MMAC1; Malignant Cell; Malignant Tumor of the Prostate; Malignant hemangioendothelioma; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Modeling; Molecular; Oncogenesis; Oncogenic; PKB protein; PTEN; PTEN gene; PTEN1; Pathway interactions; Phosphatase and Tensin Homolog; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Protein Kinase B; Proto-Oncogene Proteins c-akt; RAC-PK protein; Role; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Testing; Therapeutic; Tumor Angiogenesis; Tumor of the Prostate; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGFR-2; VEGFR2; VEGFs; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vegf; Work; angiogenesis; autocrine; biological signal transduction; c-akt protein; cancer cell; design; designing; experiment; experimental research; experimental study; in vivo; inhibitor; inhibitor/antagonist; novel; p53-Binding Protein Gene; paracrine; pathway; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; research study; response; social role; tumor; tumor growth; tumorigenesis",PI3K Pathway in Prostate Tumorigenesis and Angiogenesis,,109460,CE,Cancer Etiology Study Section,,5,227246,
7758840,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA109478-05,,NCI:206823;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,PEDIATRICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"PATI, DEBANANDA ;",7851902;,5R01CA109478,02/01/2006,01/31/2011,"Affinity Chromatography; Amino Acids; Anaphase; Apoptosis; Apoptosis Inducing Protein TRICK2A/2B; Apoptosis Pathway; Apoptotic; Articulation; Assay; B blood cells; B-Cells; B-Lymphocytes; BMH; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood (Leukemia); Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C-terminal; CSPG6; CSPG6 gene; Cachectin Receptors; Cancer Biology; Cancer Induction; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Growth in Number; Cell Growth/Cell Cycle; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Nucleus; Cell Process; Cell Proliferation; Cell Signaling; Cell Therapy; Cell physiology; Cell-Death Protease; Cell-Free System; CellLine; Cellfree System; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Proliferation; Chromatography, Affinity; Chromatography, Exclusion; Chromatography, Gel; Chromatography, Gel Permeation; Chromosome Segregation; Cleaved cell; Complex; Cytoplasm; Cytotoxic TRAIL Receptor-2; DNA Replication; DNA Synthesis; DNA biosynthesis; DR5 protein; Data; Death Domain; Death Receptor 5; Development; Disease Resistance; EC 2.7; Ensure; Enzyme Activation; Enzymes; Esteroproteases; Event; Family; Fas-Like Protein Precursor; Gel Chromatography; Gel Filtration; Gel Filtration Chromatography; Gene Expression; HCAP; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Cancer; Hematopoietic Cell Tumor; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Human; Human, General; ICE-like protease; Immune Precipitation; Immunoprecipitation; In Vitro; Induction of Apoptosis; Intracellular Communication and Signaling; Investigators; Ion Exchange; Joints; Kinases; LEUKCL; Laboratories; Lead; Leukemia, T-Cell; Leukemias, General; Leukemic Cell; Link; Lymphocytic Leukemia, T-Cell; M Phase; M phase (cell cycle); Malignant; Malignant - descriptor; Malignant Cell; Malignant Hematologic Neoplasm; Malignant Hematopoietic Neoplasm; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Metaphase; Methods and Techniques; Methods, Other; Mitochondria; Mitosis; Mitosis Stage; Mitotic; Mitotic Anaphase; Mitotic Cell Cycle; Mitotic Metaphase; Nuclear; Nuclear Protein; Nuclear Proteins; Nucleus; P53-Regulated DNA Damage-Inducible Cell Death Receptor (Killer); Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Play; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Racial Segregation; Receptor Protein; Regulation; Regulatory Protein; Research; Research Personnel; Researchers; Resistance; Resistance, Disease; Role; SMC3; SMC3L1; Series; Signal Transduction; Signal Transduction Systems; Signaling; Sister Chromatid; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Stimulus; Subcellular Process; System; System, LOINC Axis 4; T-Cell Leukemia; T-Lymphocytic Leukemia; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; TNFRSF10B; TRAIL Receptor 2; TRAIL-R2; Techniques; Testing; Tet; Tetanus Helper Peptide; Therapy, Cell; Transphosphorylases; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor Receptor Superfamily, Member 10B; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9; Two Hybrid; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; affinity purification; aminoacid; aminoacid sequence of peptide; aminoacid sequence of protein; base; biological signal transduction; blood cancer; cancer cell; carcinogenesis; cartilage link protein; caspase; cell growth; cell-based therapy; chemotherapy; cleaved; cohesin; cohesion; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; design; designing; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; in vivo; killer-DR5; leukemia; leukemia/lymphoma; link protein; lymphoma/leukemia; malignancy; mitochondrial; necrocytosis; neoplasm/cancer; novel; pathway; peptide sequence; protein aminoacid sequence; protein protein interaction; receptor; regulatory gene product; repair; repaired; resistance to disease; resistance to therapy; resistant; resistant disease; resistant to disease; resistant to therapy; response; segregation; separase; separin; social role; therapy resistant; treatment strategy; yeast two hybrid system",Mitotic Regulation of Apoptosis in Leukemia,,109478,HP,Hematopoiesis Study Section,,5,206823,
7789412,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA111196-05,,NCI:224920;,2010,NATIONAL CANCER INSTITUTE,,TAMPA,UNITED STATES,BIOCHEMISTRY,09,069687242,US,FL,33612,UNIVERSITY OF SOUTH FLORIDA,"MEDVECZKY, PETER GABOR;",1884513;,5R01CA111196,04/01/2006,02/28/2011,"2'-Nor-2'-deoxyguanosine; 2'NDG; 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 3'5'-cyclic ester of AMP; 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-; 9-((2-Hydroxyethoxy)methyl)guanine; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; 9-ene-Tetrahydrocannabinol; AIDS; Acicloftal; Aclovir; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acute; Acycloguanosine; Acyclovir; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Aging; Agonist; Animal Model; Animal Models and Related Studies; Animals, Laboratory; Antiviral Agents; Antiviral Drugs; Antivirals; Area; Assay; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Breast Carcinoma; Burkitt Herpesvirus; Burkitt Lymphoma Virus; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CB1 Receptor; CB2 Receptor; CBP protein; CBP protein, human (CREB binding protein); CRE Binding Protein; CREB; CREB Binding Protein; CREB Protein; CREB binding protein, human; CREB-binding protein; CREBBP protein, human; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cancer Causing Agents; Cancers; Cannabinoids; Cannabinoids, Endogenous; Carcinogens; Cargosil; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cell surface; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical, Transplantation, Organ; Computer Systems Development; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; DHPG; DNA; DNA, Viral; Data; Delta-9-Tetrahydrocannabinol; Deoxyribonucleic Acid; Development; Development, Computer Systems; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dronabinol; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; E-B Virus; EB virus; EBV; EBV Infections; Endocannabinoids; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus Infections; Event; Experimental Designs; Fibroblasts; Foundations; Frequencies (time pattern); Frequency; Ganciclovir; Gancyclovir; Gene Expression; Gene Targeting; Generalized Growth; Genes; Genes, Viral; Genetics-Mutagenesis; Genome; Germinoblastoma; Glaxo Wellcome Brand of Aciclovir; Glaxo Wellcome Brand of Aciclovir Sodium Salt; Grafting Procedure; Growth; HHV-4; HHV-8; HHV8; Herpes Simplex; Herpes Simplex Infections; Herpes simplex disease; Herpesviridae; Herpesviridae Infections; Herpesviridae disease; Herpesvirus 2 (gamma), Saimirine; Herpesvirus 2, Saimiriine; Herpesvirus 2, Saimirine; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesvirus Infections; Herpesvirus hominis disease; Herpesvirus saimiri; Herpesviruses; Human; Human Herpes Virus 4 Infections; Human Herpesvirus 4; Human Herpesvirus 4 Infections; Human, General; Immune; Immune response; Immune system; Immunologic Deficiency Syndrome, Acquired; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; In Vitro; Individual; Infection; Infection Control; Infectious Mononucleosis Virus; Intracellular Communication and Signaling; Investigators; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kidney; Knock-out; Knockout; Knockout Mice; Laboratory Animals; Latent Virus; Life; Ligands; Light; Lung; Lymphoid; Lymphoid Cell; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lytic; Lytic Cycle; Lytic Infection; Lytic Phase; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Marihuana; Marijuana Smoking; Marinol; Measures; Mediating; Medication; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular Biology, Mutagenesis; Molecular Interaction; Monitor; Monkeys; Murine; Mus; Mutagenesis; Natural immunosuppression; Nordeoxyguanosine; Nucleus; Null Mouse; ORFs; Oncogens; Open Reading Frames; Organ; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Organism; PKC; Parke Davis Brand of Aciclovir; Pathogenesis; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phospho-CREB Binding Protein; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Photoradiation; Physiologic; Physiological; Population; Poviral; Predisposition; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Coding Region; Protein Kinase C; Proteins; Psychoactive Agents; Psychoactive Compound; Psychoactive Drugs; Psychopharmaceuticals; Psychotropic Drugs; RNA, Messenger; Receptor Protein; Receptor Signaling; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Reticulolymphosarcoma; Role; Rubinstein-Taybi syndrome protein, human; Saimiriine Herpesvirus 2; Sarcoma, Germinoblastic; Senescence; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Splenocyte; Subcellular Process; Susceptibility; System; System, LOINC Axis 4; Systems Development; THC receptor; Targetings, Gene; Testing; Tetrahydrocannabinol; Time; Tissue Growth; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transplant Recipients; Transplantation Surgery; Urinary System, Kidney; Viral; Viral Diseases; Viral Genes; Virorax; Virus; Virus Diseases; Virus Replication; Virus-HHV8; Viruses, General; Warner Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir Sodium Salt; Work; Zovirax; Zovirax for Injection; adenosine 3'5' monophosphate; base; biological signal transduction; body system, allergic/immunologic; cAMP; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; cannabinoid receptor; cellular targeting; cultured cell line; cytokine; cytotoxic; delta(1)-THC; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; design; designing; disease/disorder; drug/agent; experience; experiment; experimental research; experimental study; extracellular; gammaherpesvirus; gene product; herpes virus; host response; human CREBBP protein; human herpesvirus 4 group; human herpesvirus 8; immunoresponse; immunosuppression; immunosuppressive; in vivo; infected B cell; infected B lymphocyte; knockout animal; latent infection; living system; lytic replication; lytic viral replication; lytic virus replication; mRNA; malignancy; model organism; neoplasm/cancer; novel; nuclear protein CBP; ontogeny; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; pathogen; phospho-CREB-binding protein; pulmonary; reactivation from latency; receptor; renal; research study; resistant; response; senescent; social role; tetrahydrocannabinol receptor; tissue culture; tool; transplant patient; viral DNA; viral infection; virus DNA; virus infection; virus multiplication",MODULATION OF ONCOGENIC AGENTS BY MARIJUANA,,111196,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,5,224920,
7766952,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA111922-03,,NCI:598914;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,NONE,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"WU, XIFENG ;",1904144;,5R01CA111922,03/10/2008,01/31/2013,"17p; 3,4-Benzopyrene; 3,4-Benzpyrene; Aberrant Chromosome; Abnormalities, Chromosomal; Adenocarcinoma of the Esophagus; Age; Alcohol Drinking; Alcohol consumption; American; Area; Assay; BMI percentile; BMI z-score; Base Excision Repairs; Benzo(a)pyrene; Bioassay; Biochemical; Biologic Assays; Biological Assay; Bladder; Blood Sample; Blood specimen; Body Tissues; Body mass index; Cancer Center; Cancer Induction; Cancer Radiotherapy; Cancer of Lung; Cancer of the Esophagus; Cancers; Carcinoma of the Esophagus; Causality; Cause of Death; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Chromosomal Aberrations; Chromosomal Alterations; Chromosomal Instability; Chromosome 17 Proximal Arm; Chromosome 17 Short Arm; Chromosome 17p; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome Instability; Chromosome abnormality; Chromosomes; Clinical; Clinical Oncology; Comet Assay; Constitutional; Country; Cytogenetic Aberrations; Cytogenetic Abnormalities; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA Molecular Biology; DNA Repair; DNA Repair Gene; Data; Death; Development; Diagnosis; Diet; Dietary intake; Digit; Digit structure; Disease; Disorder; Doctor of Medicine; Double Strand Break Repair; Drug usage; Dysfunction; Early Diagnosis; Epidemiologic Determinants; Epidemiologic Factors; Epidemiology; Epidemiology, Personal Medical History; Epithelial; Epoxides; Epoxy Compounds; Esophageal; Esophageal Adenocarcinoma; Esophageal Cancer; Esophageal Epidermoid Carcinoma; Esophageal SCC; Esophageal Squamous Cell Carcinoma; Esophageal carcinoma; Esophagus Cancer; EtOH drinking; Ethnic Origin; Ethnicity; Ethnicity aspects; Etiology; Exhibits; Family Cancer History; Forecast of outcome; Foundations; Frequencies (time pattern); Frequency; Functional disorder; Funding; Gel Electrophoresis, Single-Cell; Gender; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Markers; Genetic Polymorphism; Genetic defect; Genome Instability; Genomic Instability; Genotoxins; Genotype; Glycols; Goals; Health Benefit; Human; Human, General; Image; Incidence; Individual; Infrastructure; Intervention; Intervention Strategies; Interview; Investigation; Investigators; Kidney; Knowledge; Length; Length Maintenance; Light; Lymphocyte; Lymphocytic; M.D.; MDACC; Malignant Esophageal Neoplasm; Malignant Esophageal Tumor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Esophagus; Malignant Tumor of the Lung; Malignant neoplasm of esophagus; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Markers, Surrogate; Measures; Medical History; Methods; Modeling; Molecular; Molecular Biology; Mutagens; Mutation; Natural History; Normal Tissue; Normal tissue morphology; Nucleotide Excision Repair; Obesity; Occupational Exposure; Oncogenesis; PBL; Pathway interactions; Patients; Peripheral Blood Lymphocyte; Personal Medical History; Phenotype; Photoradiation; Physical activity; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Position; Positioning Attribute; Predisposition; Procedures; Prognosis; Public Health; Pulmonary Cancer; Pulmonary malignant Neoplasm; Quetelet index; Radiation; Radiation therapy; Radiotherapeutics; Radiotherapy; Recruitment Activity; Repairs, Base Excision; Research Infrastructure; Research Personnel; Researchers; Residencies; Risk; Risk Assessment; Risk Marker; Role; SCC of the Esophagus; SNP; SNPs; SUBGP; Screening procedure; Series; Single Nucleotide Polymorphism; Smoke; Smoking History; Squamous Cell Carcinoma of the Esophagus; Subgroup; Surrogate Markers; Survival Rate; Susceptibility; System; System, LOINC Axis 4; Telomere Length Maintenance; Telomere Maintenance Gene; Telomere Shortening; Texas; Time; Tissues; Tumor Tissue; United States; University of Texas M D Anderson Cancer Center; University of Texas MD Anderson Cancer Center; Unscheduled DNA Synthesis; Urinary System, Bladder; Urinary System, Kidney; Virulent; adiposity; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; anticarcinogenic; base; biomarker; carcinogenesis; case control; chemotherapy; corpulence; corpulency; corpulentia; density; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug use; early detection; epidemiologic data; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; gene repair; genome mutation; genotoxic agent; high risk; imaging; indexing; interventional strategy; irradiation; lung cancer; lymph cell; malignancy; men; men's; minimally invasive; multidisciplinary; neoplasm/cancer; obese; obese people; obese person; obese population; outcome forecast; pathophysiology; pathway; polymorphism; population based; public health medicine (field); ray (radiation); recruit; renal; repair; repaired; screening; screenings; sex; social role; telomere; tumor; tumorigenesis; urinary bladder",Genetic Instability & Risk for Esophageal Carcinoma,"PUBLIC HEALTH RELEVANCE: Esophageal cancer (EC) is the seventh leading cause of death from cancer among American men, and more than 90% of patients diagnosed with esophageal cancer will ultimately die of their disease. The vast majority of ECs are either esophageal squamous-cell carcinomas (ESCC) or esophageal adenocarcinoma (EAC). Once a rare tumor representing <10% of ECs in U.S., EAC is currently the cancer with the fastest increasing incidence in this country. In the past few decades, the incidence of EAC has increased by approximately 6-fold and replaced ESCC as the most common histological type in this country since the mid 1990s, whereas ESCC still predominates in eastern countries. The reason for this dramatic increase of EAC in western countries is unknown. In this application, we will recruit 600 EAC patients and 600 controls. We will collect comprehensive epidemiologic profiles and perform a series of genetic and biochemical assays. We will assess the associations between a variety of epidemiologic factors, such smoking history, alcohol consumption, dietary intake, obesity, physical activity, cancer family history, occupational exposures, previous medical history, etc., with the risk of EAC. We will also assess biomarkers that may predict the development of EAC. The long-term goal of this project is to build up a comprehensive risk assessment model for EAC and shed light on the dramatic increase of EAC incidence. The ability to identify high-risk subgroups of individuals for EAC will provide immense public health benefit for those high-risk people who may be subjected to close surveillance and chemoprevention.",111922,ZRG1,Special Emphasis Panel,,3,598914,
7767763,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA112093-05,,NCI:298355;,2010,NATIONAL CANCER INSTITUTE,,BERKELEY,UNITED STATES,BIOPHYSICS,09,078576738,US,CA,947208202,UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB,"TAINER, JOHN A;",1864252;,5R01CA112093,04/01/2006,02/28/2011,"ATP phosphohydrolase; ATPase; Adenosine Triphosphatase; Adenosinetriphosphatase; Aging, Premature; Amish brittle hair syndrome; Angioma Pigmentosum Atrophicum; Architecture; Atrophoderma Pigmentosum; BTF2; BTF2 transcription factor; BTF2-p89 Gene; Basic Transcription Factor 2 89 kDa Subunit Gene; Biochemical; Biochemistry; Biological; Biological Function; Biological Process; Biophysics; Cancers; Cell Death; Chemistry, Biological; Cockayne Syndrome; Complex; DNA; DNA Alteration; DNA Damage; DNA Damage Repair; DNA Helicases; DNA Injury; DNA Repair; DNA Unwinding Proteins; DNA mutation; DNA unwinding enzyme; Defect; Deoxyribonucleic Acid; Disease; Disorder; ERCC3; ERCC3 gene; ERCC5 protein; Electrons; Engineering / Architecture; Eukaryota; Eukaryote; Event; Figs; Figs - dietary; GTF2H; Gene Alteration; Gene Mutation; Gene Transcription; GeneHomolog; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic mutation; Germ-Line Mutation; Germline Mutation; Hereditary; Hereditary Mutation; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Inherited; Kaposi Dermatosis; Kaposi Disease; Knowledge; Laboratories; Lead; Length; Link; Macromolecular Structure; Malignant Cell; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Man (Taxonomy); Man, Modern; Maps; Mediating; Melanoma and Non-Melanoma Skin Cancer; Melanosis Lenticularis Progressiva; Mental Retardation; Microscopic; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Molecular Structure; Mutation; Negative Beta Particle; Negatrons; Nerve Degeneration; Neuron Degeneration; Nucleotide Excision Repair; Outcome; Pathway interactions; Patients; Pb element; Phenotype; Pigmented Epitheliomatosis; Predisposition; Premature aging syndrome; Process; Progeria-Like Syndrome; Proteins; RAD25; RNA Expression; Repair Complex; Resolution; Role; Sequence Alteration; Skin Cancer; Skin Cancer, Including Melanoma; Specificity; Structure; Structure-Activity Relationship; Susceptibility; Syndrome; TFIIH; TFIIH 89 kDa Subunit Gene; TFIIH Basal Transcription Factor Complex Helicase XPB Subunit Gene; Testing; Transcription; Transcription Initiation; Transcription, Genetic; Transcription-Coupled Nucleotide Excision Repair; Transcription-Coupled Repair; Trichothiodystrophy; Unscheduled DNA Synthesis; XP-G correcting protein; XPB; XPG protein; XPGC protein; Xeroderma Pigmentosum; Xeroderma Pigmentosum Syndrome; Xeroderma of Kaposi; base; basic transcription factor 2; brittle hair-intellectual impairment-decreased fertility-short stature (BIDS) syndrome; brittle hair-intellectual impairment-decreased fertility-short stature syndrome; cancer cell; chemical structure function; clinical phenotype; conformation; conformational state; disease phenotype; disease-causing mutation; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; hair-brain syndrome; heavy metal Pb; heavy metal lead; helicase; human disease; in vivo; malignancy; mutant; necrocytosis; neoplasm/cancer; neural degeneration; neurodegeneration; neuronal degeneration; pathway; protein protein interaction; repair; repaired; research study; social role; structural biology; structure function relationship; transcription factor IIH; transcription factor TFIIH; trichothiodystrophy (TTD); xeroderma pigmentosum-G complementing protein; xeroderma pigmentosum-G correcting protein",Structural Biology of XPB and XPD Helicases,,112093,RTB,Radiation Therapeutics and Biology Study Section,,5,298355,
7759153,R01,CA,5,,01/12/2010,12/31/2010,,5R01CA112519-05,,NCI:340769;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,SURGERY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"ALI-OSMAN, FRANCIS ;",1873282;,5R01CA112519,02/10/2006,12/31/2010,"21+ years old; Active Sites; Adult; Affinity; Anaplastic Astrocytic Neoplasm; Anaplastic Astrocytic Tumor; Anaplastic astrocytoma; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Apoptotic; Astrocytes; Astrocytoma, Grade III; Astrocytoma, Grade IV; Astrocytus; Astroglia; Behavior; Binding; Binding (Molecular Function); Biological Factors; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CNS Neoplasms, Malignant; CNS Tumor; CNS neoplasm; Cancer Drug; Cancer of Brain; Cancer of the CNS; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Cellular Stress; Central Nervous System; Central Nervous System Cancer; Central Nervous System Neoplasms; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Common Neoplasm; Common Tumor; Computer Simulation; Computerized Models; DFN7; Defect; Development; Disease; Disorder; Drug resistance; Drugs; EC 2.5.1.18; EC 2.7; Encephalon; Encephalons; Exhibits; FAEES3; FLR; Factor, Biologic; Failure (biologic function); Fatty Acid Ethyl Ester Synthase III Gene; Forecast of outcome; GFAC; GST; GST3; GST3 Gene; GSTP1; GSTP1 gene; GSTPP; Generalized Growth; Generations; Genes; Genetic Polymorphism; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione S-Transferase Pi Gene; Glutathione Transferase; Goals; Grade III Astrocytic Neoplasm; Grade III Astrocytic Tumor; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heme Transfer Protein; High Throughput Assay; Human; Human, Adult; Human, General; Hypoxia; Hypoxic; In Vitro; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; LTS; Laboratories; Lead; Libraries; Ligandins; Ligands; Long-Term Survivors; METBL; Malignant; Malignant - descriptor; Malignant Astrocytoma; Malignant Childhood Central Nervous System Neoplasm; Malignant Childhood Neoplasm of the CNS; Malignant Childhood Tumor of the CNS; Malignant Childhood Tumor of the Central Nervous System; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neoplasms; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Malignant Pediatric Neoplasm of the CNS; Malignant Pediatric Neoplasm of the Central Nervous System; Malignant Pediatric Tumor of the CNS; Malignant Pediatric Tumor of the Central Nervous System; Malignant Tumor; Malignant Tumor of the Brain; Malignant Tumor of the CNS; Malignant Tumor of the Central Nervous System; Malignant neoplasm of brain; Malignant neoplasm of central nervous system; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Medication; Metabolic; Metabolic Processes; Metabolism; Models, Computer; Molecular; Molecular Interaction; N-terminal; NH2-terminal; NRVS-SYS; National Institute of Neurological Disorders and Stroke; Natural Products; Neoplasms of Neuroglia; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurocyte; Neuroglial Neoplasm; Neuroglial Tumor; Neurologic Body System; Neurologic Organ System; Neurons; Nuclear; Organ; Outcome; Oxygen Deficiency; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Polymorphism (Genetics); Polymorphism, Genetic; Prognosis; Progress Review Group; Proteins; RX[{..}]glutathione R-transferase; Reporting; Research; Role; S-Hydroxyalkyl Glutathione Lyase; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Sites, Active; Specificity; Structure; Survivors, Long-Term; Testing; Therapeutic; Therapeutic Agents; Therapeutic Index; Tissue Growth; Transphosphorylases; Tumor Biology; Tumor Cell; Tumor-Specific Treatment Agents; Tumors of Neuroglia; Tumors, Central Nervous System; adult human (21+); anti-cancer therapeutic; anticancer agent; anticancer drug; anticancer therapeutic; antitumor drug; base; biological signal transduction; cancer progression; chemotherapeutic agent; chemotherapy; clinical efficacy; combinatorial chemistry; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; disease/disorder; drug discovery; drug resistant; drug/agent; effective therapy; failure; gene product; glioblastoma multiforme; glutathione aralkyltransferase; glutathione aryltransferase; heavy metal Pb; heavy metal lead; high throughput screening; in silico; in vivo; inhibitor; inhibitor/antagonist; insight; malignancy; malignant astrocyte; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; neuronal; new therapeutic target; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; outcome forecast; overexpression; pathway; polymorphism; resistance to Drug; resistant to Drug; response; small molecule; social role; spongioblastoma multiforme; therapeutic target; tumor; tumor progression; tumors in the brain; tumors in the central nervous system; virtual simulation",Novel Targeted Therapeutics for Cental Nervous System Malignancies,,112519,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,340769,
7759607,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113395-05,,NCI:286106;,2010,NATIONAL CANCER INSTITUTE,,BRONX,UNITED STATES,ANATOMY/CELL BIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CONDEELIS, JOHN S;",1864732;,5R01CA113395,03/13/2006,01/31/2011,"Arts; Autocrine Systems; Behavior; Blood Vessels; Breast Neoplasms; Breast Tumors; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Common Rat Strains; Expression Profiling; Expression Signature; Gene Expression; Genes; Human; Human, General; Image; In Vitro; Intracellular Communication and Signaling; Mammals, Mice; Mammals, Rats; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Measures; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Molecular Fingerprinting; Molecular Profiling; Motility; Motility, Cellular; Murine; Mus; Neoplasm Metastasis; Pattern; Primary Neoplasm; Primary Tumor; Rat; Rattus; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Stromal Cells; Testing; Therapeutic; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; autocrine; biological signal transduction; cancer metastasis; cell behavior; cell motility; cell type; cohort; imaging; in vivo; mammary tumor; molecuar profile; molecular signature; neoplastic cell; new technology; paracrine; prognostic; reconstitute; reconstitution; tumor; vascular",MICROENVIRONMENTS OF INVASION IN HUMAN BREAST TUMORS,,113395,TME,Tumor Microenvironment Study Section,,5,286106,
7758237,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113449-05,,NCI:266623;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"CHUNG, FUNG-LUNG ;",1867978;,5R01CA113449,03/16/2006,01/31/2011,"1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 2'-deoxy-7,8-dihydro-8-oxoguanosine; 2'-deoxy-8-hydroxyguanosine; 3,4-Benzopyrene; 3,4-Benzpyrene; 7-hydro-8-oxodeoxyguanosine; 8-OH-dG; 8-Oxo-2'-Deoxyguanosine; 8-Oxo-dG; 8-hydroxy-2'-deoxyguanosine; 8-hydroxydeoxyguanosine; 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxo-7,8-dihydrodeoxyguanosine; 8-oxo-7-hydrodeoxyguanosine; 8-oxo-dGuo; 8-oxodG; 8-oxodGuo; Active Oxygen; Address; Agreement; Animals; Animals, Laboratory; Antioxidants; Apoptosis; Apoptosis Pathway; Assay; Benzo(a)pyrene; Bioassay; Biologic Assays; Biological Assay; Black Tea; Body Tissues; Buccal Mucosa; Butanones; CPB6; CYP2B; CYP2B6 protein, human; CYPIIB6; Caffeine; Cancer Causing Agents; Cancer Induction; Cancers; Carcinogen Metabolism; Carcinogen-DNA Adducts; Carcinogens; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Cellular injury; Clinical; Common Rat Strains; Conflict; Conflict (Psychology); Consumption; Control Groups; Controlled Study; Cultured Cells; Cytochrome P450 2B6; Cytochrome P450 CYP2B6; Cytochrome P450 Family 2 Subfamily B Polypeptide 6; DNA; DNA Adduct Formation; DNA Adduction; DNA Adducts; DNA Damage; DNA Injury; DNA lesion; Data; Deoxyguanosine; Deoxyribonucleic Acid; Development; Doctor of Philosophy; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Metabolic Detoxication; EGCG; EGCG cpd; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epigallocatechin Gallate; Epigallocatechingallate; Generalized Growth; Genes, p53; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Green Tea Extract; Green Tea Polyphenols; Green tea (dietary); Growth; Guanosine, 2'-deoxy-; Harvest; Hepatic; Host Defense; Human; Human, General; Hydrogen Oxide; Hydroxyl; Hydroxyl Radical; IIB1; Incidence; Intermediary Metabolism; Intervention Studies; Intervention Trial; Investigators; Laboratory Animals; Laboratory Study; Lead; Lesion; Lip and Oral Cavity Neoplasm; Lip and Oral Cavity Tumour; Lipid Peroxidation; Liver; Lung; Lung Neoplasms; METBL; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tumor; Malignant Tumor of the Mouth; Malignant neoplasm of mouth; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mechanics; Metabolic Activation; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Methods; Mice; Modeling; Molecular; Mouth Cancer; Mouth Mucosa; Mouth Neoplasms; Mouth Tumor; Murine; Mus; Nicotine; Non-smoker; O-D-DG; Oncogens; Oral; Oral Cancer; Oral Cavity Neoplasm; Oral Cavity Tumor; Oral Mucosa; Oral Neoplasms; Oral Tumor; Oral mucous membrane structure; Oxidants; Oxidizing Agents; Oxygen Radicals; P450 IIB1; P53; PBO; Pathway interactions; Pb element; Ph.D.; PhD; Phase; Placebos; Play; Prevention; Prevention of Oral Cancer; Pro-Oxidants; Process; Programs (PT); Programs [Publication Type]; Pulmonary Neoplasms; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Randomized; Rat; Rattus; Reaction; Reactive Oxygen Species; Reporting; Research Personnel; Researchers; Respiratory System, Lung; Risk; Rodent; Rodentia; Rodentias; Role; Sham Treatment; Site; Smoker; Smoking; TP53; TP53 gene; TRP53; Tea; Tea catechin; Testing; Tissue Growth; Tissues; Tobacco-Associated Carcinogen; Treatment Period; Tumor Protein p53 Gene; Tumor of the Lung; Water; adduct; anti-oxidant; body system, hepatic; cancer prevention; carcinogenesis; cell damage; cell growth; cell injury; cigarette smoke; cytochrome P-450 CYP2B6; cytochrome P-450 CYP2B6 (human); detoxification; drinking; electron acceptor; enzyme activity; epigallo-catechin gallate; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; green tea; heavy metal Pb; heavy metal lead; high risk; human CYP2B6 protein; human subject; malignancy; malignant mouth neoplasm; neoplasm/cancer; nonsmoker; ontogeny; oral cancer prevention; oral carcinogenesis; oral mucosae; oral mucosal; oral neoplasia; oral tissue; organ system, hepatic; oxidative DNA damage; pathway; polyphenol; prevent; preventing; programs; protective effect; pulmonary; randomisation; randomization; randomly assigned; repair; repaired; response; sham therapy; smoke of cigarettes; social role; tool; treatment days; treatment duration; treatment effect; tumor",Prevention of Oral Cancer by Tea: A mechanism Study,,113449,ZRG1,Special Emphasis Panel,,5,266623,
7762746,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113519-05,,NCI:238105;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"DATTA, PRAN K;",6879913;,5R01CA113519,03/01/2006,01/31/2011,"Affinity; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Autocrine Communication; Autocrine Signaling; Autocrine Systems; Bioassay; Biologic Assays; Biological; Biological Assay; Bone-Derived Transforming Growth Factor; CHIP assay; Cancer Drug; Cancer cell line; Cancer of Lung; Carcinoma in Situ; Carcinoma, Intraepithelial; Carcinoma, Preinvasive; Cell Communication and Signaling; Cell Line, Tumor; Cell Signaling; ChIP (chromatin immunoprecipitation); Chemotherapeutic Agents, Neoplastic Disease; Clinical Trials; Clinical Trials, Unspecified; Complex; Data; Disseminated Malignant Neoplasm; Down-Regulation; Down-Regulation (Physiology); Downregulation; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelium; Equilibrium; Generalized Growth; Genetic; Growth; HDAC; HDAC Agent; HDAC Proteins; Histone Deacetylase; Histone Deacetylase Inhibitor; Histone Deacetylation; Human; Human, General; Hypermethylation; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Lung; Lung Neoplasms; MS-275; Malignant Cell; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Metastatic Cancer; Metastatic Malignant Neoplasm; Milk Growth Factor; Molecular; Oligo; Oligonucleotides; Pathway interactions; Patients; Pattern; Pb element; Phase; Platelet Transforming Growth Factor; Play; Pre-Malignant; Precipitation; Premalignant; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteomics; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; Receptor Protein; Resistance; Respiratory System, Lung; Response Elements; Role; Signal Transduction; Signal Transduction Systems; Signaling; Staging; TGF B; TGF-beta; TGFbeta; Testing; Therapeutic Intervention; Tissue Growth; Transforming Growth Factor beta; Tumor Cell Line; Tumor Suppressor Proteins; Tumor Tissue; Tumor of the Lung; Tumor-Specific Treatment Agents; Tumorigenicity; anticancer agent; anticancer drug; autocrine; balance; balance function; base; biological signal transduction; cancer cell; cancer progression; chromatin immunoprecipitation; clinical investigation; drug development; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; improved; in situ cancer; insight; intervention therapy; interventional strategy; lung cancer; lung carcinogenesis; lung tumorigenesis; neoplasm progression; neoplastic progression; ontogeny; pathway; precancerous; prognostic; protein complex; pulmonary; receptor; receptor expression; research study; resistant; restoration; social role; transcription factor; tumor; tumor progression; tumor suppressor",Targeting TGF-beta Signaling in Lung Cancer,,113519,DT,Developmental Therapeutics Study Section,,5,238105,
7756584,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113564-05,,NCI:317449;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"HOUGHTON, JEANMARIE ;",1892639;,5R01CA113564,03/01/2006,01/31/2011,"APO-1 Antigen; APO-1 Cell Surface Antigen; Actins; Adaptor Protein; Adaptor Signaling Protein; Age; Apoptosis; Apoptosis Antigen 1; Apoptosis Pathway; Apoptotic; Area; Atrophic; Atrophy; Bypass; CD95 Antigens; CD95 molecule; CSBP1; CSBP2; CSPB1; Cancer Genes; Cancer Model; Cancer Radiotherapy; Cancer Treatment; Cancer cell line; Cancer of the Fundus of the Stomach; Cancer of the Gastric Body; Cancer of the Gastric Cardia; Cancer of the Gastric Fundus; Cancer of the Gastric Pylorus; Cancer of the Pylorus of the Stomach; Cancer-Promoting Gene; CancerModel; Cancers; Capping, Receptor; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chief Cell; Class II Antigens; Class II Major Histocompatibility Antigens; Complex; DNA Alteration; DNA mutation; Development; Disease; Disorder; Dysplasia; EXIP; Evaluation; Gastric Adenocarcinoma; Gastric Cancer; Gastric Tissue; Gastric mucosa; Gene Alteration; Gene Mutation; Genetic mutation; Genome Instability; Genomic Instability; Goals; Grant; Helicobacter; Helicobacter Infections; Helicobacter Pylori Infection; Histocompatibility Antigens Class II; Human; Human, General; I-A Antigen; INFLM; Ia Antigens; Ia-Like Antigens; Immobilization; Immune; Immune Response Antigens; Immune-Response-Associated Antigens; In Vitro; Infection; Inflammation; Inhibition of Apoptosis; Innovative Therapy; Intracellular Communication and Signaling; Investigators; Knockout Mice; Lead; Lesion; Lipid Rafts, Cell Membrane; MAPK14; MAPK14 gene; MHC Class II Molecule; MHC Class II Protein; MHC class II antigen; Major Histocompatibility Complex Class II; Malignant; Malignant - descriptor; Malignant Gastric Neoplasm; Malignant Gastric Tumor; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Stomach; Malignant neoplasm of stomach; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Membrane Microdomains; Metaplasia; Metaplastic; Metaplastic Change; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Monitor; Murine; Mus; Mxi2; Null Mouse; Oncogenes; PRKM14; PRKM15; Parietal; Pathway interactions; Pb element; Phenotype; Physiologic; Physiological; Pre-Malignant; Premalignant; Prevention; Preventive; Programs (PT); Programs [Publication Type]; Proteins; Radiation Sensitivity; Radiation Tolerance; Radiation therapy; Radio; Radiosensitivity; Radiotherapeutics; Radiotherapy; Receptor Aggregation; Receptor Protein; Recruitment Activity; Research Personnel; Researchers; Resistance; Role; SAPK2A; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stomach; Stomach Adenocarcinoma; Stomach Cancer; Structure; Surface; TNFRSF6 Receptor; Testing; Therapy, Innovative; Time; Training; Transforming Genes; Tumor Cell; Tumor Necrosis Factor Receptor Superfamily, Member 6; Work; anticancer therapy; biological signal transduction; cancer initiation; cancer therapy; chemotherapy; dimer; disease/disorder; dyscrasia; experiment; experimental research; experimental study; fas Antigens; fas Receptors; gastric; gene product; heavy metal Pb; heavy metal lead; immobilization of body part; improved; in vitro Model; in vivo; in vivo Model; insight; irradiation; knock-down; lipid raft; malignancy; malignant stomach neoplasm; mitochondrial; mouse model; neoplasm/cancer; neoplastic; neoplastic cell; new approaches; novel; novel approaches; novel strategies; novel strategy; orthopedic freezing; p38; p38 MAPK Gene; p38Alpha; pathway; precancerous; prevent; preventing; programs; receptor; receptor expression; recruit; research study; resistant; response; restoration; social role; trait; tumor; tumor growth",Inhibition of Fas-apoptosis in Gastric Cancer,,113564,CAMP,Cancer Molecular Pathobiology Study Section,,5,317449,
7761673,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA113655-05,,NCI:318235;,2010,NATIONAL CANCER INSTITUTE,,BUFFALO,UNITED STATES,,28,824771034,US,NY,14263,ROSWELL PARK CANCER INSTITUTE CORP,"SINGH, KESHAV K.;",1870778;,5R01CA113655,04/01/2006,02/28/2011,"ATP biosynthesis (oxidative); Active Oxygen; Animal Model; Animal Models and Related Studies; Antimycin A; Butanoic acid, 2(or 3)-methyl-, 3-((3-(formylamino)-2-hydroxybenzoyl)amino)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester; Canavanine; Cancer Induction; Cancers; Cell Nucleus; Cells; DNA, Mitochondrial; Data; Disease; Disorder; Dysfunction; Enzymes; Event; Frequencies (time pattern); Frequency; Functional disorder; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Human; Human, General; L-Homoserine, O-((aminoiminomethyl)amino)-; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Membrane Transport; Metabolic; Mitochondria; Mitochondrial DNA; Molecular; Molecular Biology, Mutagenesis; Molecular Genetic; Molecular Genetics; Mutagenesis; Mutation; Nature; Nuclear; Nucleus; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxidative Stress; Oxygen Radicals; Pathway interactions; Pentas; Phenotype; Physiopathology; Pro-Oxidants; Proteins; Reactive Oxygen Species; Research; Resistance; Role; S cerevisiae; Saccharomyces cerevisiae; System; System, LOINC Axis 4; Testing; Transmembrane Transport; Yeast, Baker's; Yeast, Brewer's; Yeasts; base; biological adaptation to stress; cancer cell; carcinogenesis; cell type; disease/disorder; gene product; genome mutation; insight; malignancy; mitochondrial; mitochondrial DNA mutation; mitochondrial dysfunction; mitochondrial genome; model organism; mtDNA; mtDNA mutation; mutant; neoplasm/cancer; novel; pathophysiology; pathway; reaction; crisis; repair; repaired; resistant; response; rho; social role; stress response; stress; reaction",Mitochondria and Mutagenesis,,113655,CE,Cancer Etiology Study Section,,5,318235,
7760656,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113851-04,,NCI:322050;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"DEMARIA, SANDRA ;",6491069;,5R01CA113851,04/01/2007,01/31/2012,"ATGN; Adjuvant; Antibodies; Antigen Presentation; Antigens; BONZO; Behavior; Breast Carcinoma; CD8; CD8B; CD8B1; CD8B1 gene; CXCR6; CXCR6 gene; Cancer Induction; Cancer Patient; Cancer Radiotherapy; Cancer Treatment; Cancer of Breast; Carcinoma; Carcinoma of prostate; Cell Mediated Immunology; Cell-Mediated Immunity; Cells; Cellular Immunity; Cessation of life; Clinical; Clinical Data; Clinical Trials; Clinical Trials, Unspecified; Cross-Priming; Cytokines, Chemotactic; Cytotoxic cell; Data; Death; Dendritic cell activation; Disease; Disease-Free Survival; Disorder; Effectiveness; Electromagnetic Radiation, Ionizing; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Event-Free Survival; FLR; Failure (biologic function); Fluorescence; Future; Homologous Chemotactic Cytokines; INFLM; ITX; IVM; Image; Immune; Immune Cell Activation; Immunity, Cellular; Immunoactivators; Immunoadjuvants; Immunologic Adjuvants; Immunological Adjuvant; Immunologically Directed Therapy; Immunopotentiators; Immunostimulants; Immunotherapy; Inflammation; Intercrines; Investigation; Ionizing radiation; K lymphocyte; LYT3; Liver; Local Cancer; Localized Cancer; Localized Malignancy; Localized Malignant Neoplasm; Lung; Lymph node proper; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Carcinoma; Mammary Glands, Human; Mammary gland; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Transgenic; Modeling; Murine; Mus; NK Cells; Natural Killer Cells; Neoplasm Metastasis; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Neoplasm; Primary Tumor; Process; Prostate carcinoma; Prostatic; Prostatic carcinoma; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation; Radiation therapy; Radiation-Ionizing Total; Radiotherapeutics; Radiotherapy; Receptor Protein; Reporter; Respiratory System, Lung; Reticuloendothelial System, Lymph Node; Role; SIS cytokines; STRL33; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Site; Solid Neoplasm; Solid Tumor; T-Cell Depletion; T-Cells; T-Lymphocyte; TYMSTR; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Transgenic Mice; Tumor Antigens; Tumor Burden; Tumor Cell; Tumor Cell Migration; Tumor Immunity; Tumor Load; Tumor-Associated Antigen; anticancer therapy; body system, hepatic; cancer metastasis; cancer therapy; carcinogenesis; chemoattractant cytokine; chemokine; clinical investigation; disease/disorder; epithelial carcinoma; failure; gene product; imaging; immune adjuvant; immune therapy; immunogen; in vivo; innovate; innovation; innovative; intravital microscopy; irradiation; lymph gland; lymph nodes; malignant breast neoplasm; mammary; migration; mouse model; neoplastic cell; new therapeutics; next generation therapeutics; novel therapeutics; organ system, hepatic; pre-clinical; preclinical; prostatic cancer, carcinoma; pulmonary; ray (radiation); receptor; response; social role; thymus derived lymphocyte; trafficking; tumor; tumor-specific antigen; uptake; vaccination strategy",Local Radiation as an Adjuvant for Immunotherapy,,113851,ZRG1,Special Emphasis Panel,,4,322050,
7761191,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA113859-05,,NCI:249951;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,OBSTETRICS & GYNECOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"HU, MICKEY C-T;",7595872;,5R01CA113859,03/10/2006,12/31/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Active Transport, Cell Nucleus; Animal Model; Animal Models and Related Studies; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Breast Cancer Cell; Cancer Drug; Cancer of Breast; Cell Culture Techniques; Cell Cycle Arrest; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cellular Proliferation; Chemotherapeutic Agents, Neoplastic Disease; Complex; Cytoplasm; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Exclusion; F Box; F Box Domain; Gene Expression; Generalized Growth; Genetic Screening; Goals; Growth; HMG-20; High Mobility Protein 20; Human Breast Cancer Cell; In Vitro; Kinases; Knowledge; Lead; Macropain; Macroxyproteinase; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammalian Cell; Mediating; Mitotic; Molecular; Molecular Target; Multicatalytic Proteinase; Nuclear; Nuclear Transport; Nucleocytoplasmic Shuttling; Nucleus; Oncogenesis; Pathway interactions; Pb element; Peptides; Phosphorylation; Phosphotransferases; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Protein Cleavage; Protein Phosphorylation; Proteins; Proteolysis; Proteosome; Regulation; Reporting; Role; Therapeutic Intervention; Tissue Growth; Translating; Translatings; Transphosphorylases; Tumor Suppression; Tumor Suppression, Molecular; Tumor-Specific Treatment Agents; Ubiquitilation; Ubiquitin; Ubiquitin Protein Ligase; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; anticancer agent; anticancer drug; biological adaptation to stress; chemical genetics; cytokine; drug discovery; fork head protein; forkhead protein; forkhead transcription factors; gene product; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; language translation; malignant breast neoplasm; model organism; multicatalytic endopeptidase complex; novel; nucleocytoplasmic transport; ontogeny; pathway; programs; reaction; crisis; small molecule; social role; stress response; stress; reaction; tumor; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase",The Role of Regulation of FOXO3a in Tumor Suppression,,113859,ZRG1,Special Emphasis Panel,,5,249951,
7756668,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA113863-05,,NCI:257607;,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,BIOCHEMISTRY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"WANG, YUH-HWA ;",2218968;,5R01CA113863,03/13/2006,01/31/2011,"10q11.2; 10q21; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-; ARA70; ARA70 Gene; ARA70/ELE1; Accounting; After Care; After-Treatment; Aftercare; Androgen Receptor Coactivator Gene, 70-kD; Androgen Receptor-Associated Protein; Androgen Receptor-Specific Coactivator; Aphidicolin; Area; BRCA1; BRCA1 gene; BUdR; BrdU; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer Type 1 Susceptibility Gene; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CDHF12; Cancer Induction; Cancer Patient; Cancers; Carcinoma, Papillary; Cell Nucleus; Cells; Characteristics; Chemicals; Chromosomal Rearrangement; Chromosome Fragile Sites; Closure by Ligation; DNA; DNA Damage; DNA Endonuclease; DNA Injury; DNA Rearrangement; DNA Replication; DNA Replication Order, Temporal; DNA Replication Pattern, Temporal; DNA Replication Timing; DNA Sequence Rearrangement; DNA Structure; DNA Synthesis; DNA biosynthesis; DNase; DNase I; Data; Deoxyribonuclease I; Deoxyribonucleic Acid; Development; ELE1; ELE1 Gene; Electromagnetic Radiation, Ionizing; Exhibits; Fragile Site; Frequencies (time pattern); Frequency; Gene Rearranged During Transfection; Gene Rearrangement; Generations; Genes; Genetics, in situ Hybridization; Head and Neck, Thyroid; Hereditary Breast Cancer 1; History; Human; Human, General; In Situ Hybridization; In Vitro; Intervening Sequences; Introns; Ionizing radiation; Lead; Ligation; Malignant Cell; Malignant Neoplasms; Malignant Thyroid Gland Neoplasm; Malignant Tumor; Malignant Tumor of the Thyroid; Malignant Tumor of the Thyroid Gland; Malignant neoplasm of thyroid; Man (Taxonomy); Man, Modern; Maps; Measures; Mediating; Modeling; Molecular; Molecular Analysis; Molecular Cytogenetics; NCOA4; NCOA4 Protein; NCOA4 gene; Nuclear; Nuclear Receptor Coactivator 4; Nuclear Receptor Coactivator 4 Gene; Nucleus; PSCP; PTC; Pancreatic DNase; Papillary Carcinoma; Pb element; Play; Preventive; RET Activating Protein ELE1; RET gene; RET-Activating Gene; RET51; RFG; RFG Gene; RNF53; RT-PCR; RTPCR; Radiation; Radiation-Ionizing Total; Rearrangement; Recording of previous events; Reverse Transcriptase Polymerase Chain Reaction; Role; Site; Structure; Testing; Thymonuclease; Thyroid; Thyroid Cancer; Thyroid Gland; Thyroid Gland Neoplasm; Tumor of the Thyroid; Tumor of the Thyroid Gland; Uridine, 5-bromo-2'-deoxy-; Work; brca 1 gene; cancer cell; carcinogenesis; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; in situ Hybridization Staining Method; malignancy; neoplasm/cancer; new therapeutics; next generation therapeutics; novel therapeutics; ray (radiation); research study; reverse transcriptase PCR; social role; thyroid neoplasm",The Role of Fragile Sites in RET/PTC Rearrangement,,113863,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,5,257607,
7760143,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA114246-05,,NCI:268949;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,SURGERY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"RUBIN, J PETER;",7671644;,5R01CA114246,02/15/2006,10/31/2012,"1-((4-((dimethylphenyl)azo)dimethylphenyl)azo)-2- naphthalenol; Adherence; Adherence (attribute); Adipocytes; Adipose Cell; Adipose tissue; American; American Cancer Society; Anatomic Abnormality; Anatomical Abnormality; Animal Model; Animal Models and Related Studies; Aspiration Lipolysis; Aspiration, Mechanical; Athymic Nude Mouse; Autologous; Blood Precursor Cell; Blood Vessels; Body Tissues; Body part; Breast; Breast Cancer Cell; Breast Reconstruction; Cancer Patient; Cancer of Breast; Cancers; Cannulas; Cell Count; Cell Isolation; Cell Number; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Surface Antigens; Cell Survival; Cell Viability; Cell surface; Cells; Cellular Expansion; Cellular Growth; Chest; Cicatrix; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen; Congenital or Acquired Anatomic Abnormality; Congenital or Acquired Anatomical Abnormality; Contracture; Cosmetics; Cytofluorometry, Flow; Defect; Deformity; Distress; Drainage, Suction; Elements; Engineering; Engineerings; Equipment Malfunction; F8VWF; Failures, Device; Fat Cells; Fat Droplet; Fats; Fatty Tissue; Fatty acid glycerol esters; Flaps; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Harvest; Hematopoietic; Hematopoietic stem cells; Human; Human Breast Cancer Cell; Human, General; Implant; Implantation procedure; In Vitro; Injectable; Investigators; Island Flaps; Laboratories; Length of Stay; Lipectomy, Aspiration; Lipid Inclusion; Lipocytes; Lipolysis, Suction; Liposuction; Maintenance; Maintenances; Malfunction, Equipment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammaplasty; Mammectomy; Man (Taxonomy); Man, Modern; Mastectomy; Mature Lipocyte; Mature fat cell; Mechanics; Methods and Techniques; Methods, Other; Mice, Athymic; Mice, Nude; Microfluorometry, Flow; Morbidity; Morbidity - disease rate; Natural regeneration; Nuclear; Nude Mice; Number of Days in Hospital; Oils; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Plastic Surgeon; Procedures; Production; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Recovery; Regeneration; Research Personnel; Researchers; Rodent Model; Saline; Saline Solution; Scars; Science of Statistics; Shapes; Silicone Gels; Silicones; Site; Small Intestinal Submucosa; Societies; Solutions; Staining method; Stainings; Stains; Statistics; Suction; Suction Lipectomy; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Surgical; Surgical Flaps; Surgical Interventions; Surgical Procedure; Techniques; Thorace; Thoracic; Thorax; Time; Tissue Donors; Tissue Engineering; Tissues; Trauma; Tumor Cell; United States; VEGFs; VWD; VWF gene; Vascular Endothelial Cell; Vascular Endothelial Growth Factors; Vascular System; Vascular blood supply; Vegf; Work; adipogenesis; adipose; base; blood supply; cell growth; cell sorting; clinical relevance; clinically relevant; cosmetic product; engineered tissue; flow cytophotometry; hospital days; hospital length of stay; hospital stay; implant placement; implant procedure; implantation; in vivo; lipid biosynthesis; lipogenesis; malignancy; malignant breast neoplasm; model organism; neoplasm/cancer; neoplastic cell; oil red O; particle; precursor cell; programs; protein expression; psychosocial; reconstruction; regenerate; scaffold; scaffolding; soft tissue; statistics; surgery; tissue reconstruction; vWF; vascular; vascular supply; white adipose tissue; wound; yellow adipose tissue",Injectable Engineered Tissue for Cancer Reconstruction,,114246,ZRG1,Special Emphasis Panel,,5,268949,
7760978,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA114365-05,,NCI:271067;,2010,NATIONAL CANCER INSTITUTE,,RALEIGH,UNITED STATES,ENGINEERING (ALL TYPES),04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"GAMCSIK, MICHAEL ;",1973042;,5R01CA114365,03/17/2006,01/31/2011,"Address; After Care; After-Treatment; Aftercare; Amino Acids; Antioxidants; Apoptosis; Apoptosis Pathway; Arts; Biochemistry; Biological Models; Biomedical Engineering; Biopsy Sample; Biopsy Specimen; Blood Vessels; Body Tissues; Buffers; Cancer Treatment; Cancers; Cell Culture Techniques; Cell Death, Programmed; Cells; Characteristics; Chemistry, Biological; Clinical Research; Clinical Study; Common Rat Strains; Defense Mechanisms; Development; Disulfides; Drops; Drug resistance; Duke Comprehensive Cancer Center; Enzymes; Equilibrium; Event; Florida; Funding; Gene Expression; Generalized Growth; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Glutathione; Glutathione Metabolism; Glutathione Metabolism Pathway; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Growth; Heterogeneity; Infusion; Infusion procedures; Intermediary Metabolism; Investigation; Investigators; Isotope Labeling; Label; Laboratories; METBL; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Rats; Mammary Glands, Human; Mammary gland; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Metabolic Processes; Metabolism; Methods; Model System; Modeling; Models, Biologic; Monitor; NMR Imaging; NMR Tomography; Neoplasms of Neuroglia; Neuroglial Neoplasm; Neuroglial Tumor; Normal Tissue; Normal tissue morphology; North Carolina; Nuclear Magnetic Resonance Imaging; Oxidation-Reduction; Patients; Pilot Projects; Play; Process; Programs (PT); Programs [Publication Type]; Proliferating; Rat; Rattus; Redox; Reproducibility; Research Personnel; Researchers; Role; Sampling; Sampling Errors; Stress; System; System, LOINC Axis 4; Testing; Therapeutic; Tissue Growth; Tissues; Tumor Cell; Tumor Tissue; Tumors of Neuroglia; Universities; Variant; Variation; Vascularization; Zeugmatography; aminoacid; anti-oxidant; anticancer therapy; balance; balance function; bioengineering; bioengineering/biomedical engineering; cancer cell; cancer therapy; chemotherapy; design; designing; drug resistant; experiment; experimental research; experimental study; fibrosarcoma; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; in vivo; insight; malignancy; mammary; monolayer; neoplasm/cancer; neoplastic cell; ontogeny; oxidation reduction reaction; pilot study; programs; psychological defense mechanism; research study; resistance to Drug; resistance to therapy; resistant to Drug; resistant to therapy; response; social role; stable isotope; success; therapy resistant; tumor; tumor growth; uptake; vascular",Noninvasive Monitoring Glutathione Metabolism in Tumors,,114365,MEDI,Medical Imaging Study Section,,5,271067,
7760102,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA114379-04,,NCI:816172;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"NEMESURE, BARBARA ;",2272405;,5R01CA114379,04/20/2007,01/31/2012,"Admixture; Affect; African; African American; Afro American; Afroamerican; Alleles; Allelomorphs; Antigen Receptors; Articulation; Barbados; Black Populations; Black or African American; Body Size; Caloric Intake; Cancer Cause; Cancer Etiology; Cancer Family; Cancer of Prostate; Candidate Disease Gene; Candidate Gene; Caribbean Islands; Characteristics; Chemotherapy-Hormones/Steroids; Code; Coding System; Conflict; Conflict (Psychology); Coxa; Cytokines, Chemotactic; Data; Detection; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Endocrine Gland Secretion; Energy Intake; Epidemiology, Family Medical History; Evaluation; Family Medical History; Family history of; Fats; Fatty acid glycerol esters; Future; GFAC; Gene Organization; Gene Structure; Gene Structure/Organization; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetic analyses; Genetics, Other; Genotype; Glycohemoglobin A; Glycosylated hemoglobin A; Goals; Gonadal Steroid Hormones; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Haplotypes; Hb A1; Hb A1a+b; Hb A1c; HbA1; HbA1c; Height; Hemoglobin A(1); High Prevalence; Hip; Hip region structure; Histologic; Histologically; History; Homologous Chemotactic Cytokines; Hormones; Humulin R; Hyperinsulinemia; Hyperinsulinism; Individual; Inherited Predisposition; Inherited Susceptibility; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intercrines; Intermediary Metabolism; Investigation; Investigators; Joints; Lifestyle Factors, Unspecified; Link; METBL; MODY; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Metabolic; Metabolic Processes; Metabolism; Modeling; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Other Genetics; Pathway interactions; Pattern; Persons; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Attributable Risks; Predisposition; Preventive Intervention; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Receptors, Antigen; Recording of previous events; Regulation; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Estimate; Risk Factors; Role; SIS cytokines; SNP Map; Sampling; Sex Hormones; Sex Steroid Hormones; Single Nucleotide Polymorphism Map; Staging; Susceptibility; T2D; T2DM; Testing; Therapeutic Hormone; Therapeutic Steroid Hormone; Time; Type 2 diabetes; Type II diabetes; Validation; Variant; Variation; Variation (Genetics); Weight; West Indies; adiposity; adult onset diabetes; allelic variant; anticancer research; attributable fraction; base; black American; caloric dietary content; cancer research; cancer risk; chemoattractant cytokine; chemokine; corpulence; corpulency; corpulentia; diabetes; genetic analysis; genetic etiology; genetic mechanism of disease; genetic variant; genetic vulnerability; gonadal steroids; hemoglobin A1c; indexing; interest; ketosis resistant diabetes; lifestyle factors; maturity onset diabetes; men; men's; novel; obese; obese people; obese person; obese population; pathway; polymorphism; population based; preventional intervention strategy; programs; public health relevance; sex steroid; social role; steroid hormone; steroid metabolism",Prostate Cancer in a Black Population,,114379,EPIC,Epidemiology of Cancer Study Section,,4,816172,
7762235,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA114403-05,,NCI:212356;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,928470061,US,WA,98108,SEATTLE INST FOR BIOMEDICAL/CLINICAL RES,"KUVER, RAHUL P;",1904291;,5R01CA114403,04/01/2006,02/28/2011,"American Indian; American Indians; Amerinds, South American; Anchorage-Independent Growth; Apoptosis; Apoptosis Pathway; Area; Asians; Athymic Nude Mouse; Autopsy; Bacteria; Bacterial Infections; Behavior; Bile; Bile Juice; Bile Tract; Bile fluid; Biliary; Biliary System; Biliary Tract; Biliary Tree; Biliary or Urinary Stones; Biliary tract structure; Biochemical; Biochemical Reaction; Biological; Biological Function; Biological Process; Blood leukocyte; Calculi; Cancer Induction; Cancer cell line; Cancers; Canine Species; Canis familiaris; Carcinogenesis Mechanism; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Causality; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell membrane; Cells; Cellular Expansion; Cellular Growth; Cellular Morphology; Cellular Proliferation; Cellular biology; Characteristics; Chemistry, Physical; Chile; Chinese; Chinese People; Cholangiocarcinoma; Cholangiocellular Carcinoma; Cholangitis; Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chronic; Clinical; Cytoplasmic Membrane; Disease; Disorder; Dogs; EC 2.7.2-; Effects, Longterm; Enzymatic Reaction; Enzymes; Epidemiology; Epithelial; Epithelial Cells; Epithelium; Etiology; Event; Exhibits; Exposure to; Extracellular Signal-Regulated Kinases; Frequencies (time pattern); Frequency; Gall Bladder; Gallbladder; Gallbladder / Biliar; Gallbladder Calculus; Gallbladder Cancer; Gallbladder Stone; Gallbladder/Biliary system; Gallstones; Gastrointestinal Tract, Gall Bladder; Generalized Growth; Growth; HPLC; High Pressure Liquid Chromatography; Human; Human, General; In Vitro; Incidence; Indians, American; Indians, South American; Infection; Inflammatory; Intermediary Metabolism; Intrahepatic Carcinoma of the Bile Duct; Intrahepatic Cholangiocarcinoma; Intrahepatic Cholangiocellular Carcinoma; Kinetic; Kinetics; Leukocytes; Lipid Rafts, Cell Membrane; Lipids; Long-Term Effects; MAP kinase; MAPK; METBL; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Gallbladder; Malignant neoplasm of gallbladder; Mammals, Dogs; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Maps; Marrow leukocyte; Mass Spectrum; Mass Spectrum Analysis; Mediating; Membrane Microdomains; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice, Athymic; Mice, Nude; Microbial Biofilms; Mitogen-Activated Protein Kinases; Modeling; Molecular; Molecular Bank; Molecular and Cellular Biology; Morphology; Mortality; Mortality Vital Statistics; Mucins; Mucus Glycoprotein; Mummies; NIH; National Institutes of Health; National Institutes of Health (U.S.); Native Americans; Nude Mice; Occidental; Oryctolagus cuniculus; Pathologic Processes; Pathological Processes; Pathway interactions; Patients; Peripheral Cholangiocarcinoma; Photometry/Spectrum Analysis, Mass; Physical Chemistry; Physiology; Plasma Membrane; Population; Prevalence; Prevention; Process; Production; Rabbit, Domestic; Rabbits; Race; Racial Group; Recurrence; Recurrent; Reticuloendothelial System, Leukocytes; Sampling; Signal Transduction Pathway; Site; South American; South American Indians; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Sterility; Sterols; Stocks, Racial; Stone; Structural Biochemistry; Structure; Sum; Surface; Techniques; Time; Tissue Growth; United States National Institutes of Health; White Blood Cells; White Cell; Work; bacterial disease; biliary cancer; biliary tract; biofilm; canine; carcinogenesis; cell biology; cell growth; cell morphology; cholangiosarcoma; cholelith; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; domestic dog; experience; experiment; experimental research; experimental study; in vivo; insight; interdisciplinary approach; intrahepatic; lipid raft; malignancy; necropsy; neoplasm/cancer; ontogeny; oriental; oxidation; pathway; plasmalemma; postmortem; primary sclerosing cholangitis; repository; research study; response; sterile; tumor; white blood cell; white blood corpuscle; white race",Biliary oxysterols and cholangiocarcinoma,,114403,HBPP,Hepatobiliary Pathophysiology Study Section,,5,212356,
7749939,R01,CA,5,,01/27/2010,12/31/2010,,5R01CA114422-05,,NCI:181692;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,NEUROLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"PUDUVALLI, VINAY K;",7021721;,5R01CA114422,01/05/2006,12/31/2010,"API3; API4; APO2L; Adenoviridae; Adenoviruses; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Apo-2L; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Apoptotic; Astrocytes; Astrocytus; Astroglia; Athymic Nude Mouse; BIRC4; BIRC4 gene; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Body Tissues; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Bystander Effect; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Radiotherapy; Cancers; Cell Death, Programmed; Cell surface; Cell-Death Protease; Cells; Cessation of life; Chemicals; Clinical Trials; Clinical Trials, Unspecified; Data; Death; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; EPR-1; Encephalon; Encephalons; Family member; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Heterograft; Human; Human, General; IAP4; ICE-like protease; ILP; In Vitro; Induction of Apoptosis; Investigators; Life; Ligands; Local Therapy; Localized Therapy; MIHA; Malignant; Malignant - descriptor; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neoplasms; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Malignant Tumor; Mammals, Mice; Mammals, Primates; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Athymic; Mice, Nude; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Nonmetastatic; Normal Cell; Normal Tissue; Normal tissue morphology; Nude Mice; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Pathway interactions; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primates; Programs (PT); Programs [Publication Type]; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation therapy; Radiotherapeutics; Radiotherapy; Receptor Protein; Recurrence; Recurrent; Relative; Relative (related person); Research Personnel; Researchers; Resistance; Rodent; Rodent Model; Rodentia; Rodentias; Role; Sequence-Specific Posttranscriptional Gene Silencing; Slice; Surgical; Surgical Interventions; Surgical Procedure; TL2; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TNFSF10; TNFSF10 gene; TRAIL; Testing; Therapeutic; Tissues; Toxic effect; Toxicities; Transplantation, Heterologous; Tumor Cell; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumors of Neuroglia; XIAP; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; analog; base; brain cell; caspase; chemotherapy; clinical investigation; cystein protease; cystein proteinase; cysteine endopeptidase; efficacy testing; glioma cell line; improved; in vivo; inhibitor; inhibitor/antagonist; interest; irradiation; malignancy; model organism; neoplasm/cancer; neoplastic cell; novel; pathway; programs; receptor; resistance mechanism; resistant; resistant mechanism; response; social role; surgery; survivin; tumor; tumor necrosis factor (unspecified); tumors in the brain",Efficacy and toxicity of TRAIL against gliomas,,114422,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,181692,
7761300,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA114535-05,,NCI:266285;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,GENETICS,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"LUO, GUANGBIN ;",2801725;,5R01CA114535,03/08/2006,01/31/2011,"Affect; Aging; Aging, Premature; Aneuploid; Aneuploidy; Arm; Binding; Binding (Molecular Function); Blotting, Western; Cancer Induction; Cancer Treatment; Cancerous; Cancers; Cell Aging; Cell Cycle; Cell Cycle Stage; Cell Death; Cell Division Cycle; Cell Senescence; Cells; Cellular Aging; Centromere; Chimera Protein; Chimeric Proteins; Chromatin; Chromosomal Instability; Chromosome Instability; Chromosome Segregation; DNA Damage; DNA Helicases; DNA Injury; DNA Unwinding Proteins; DNA unwinding enzyme; Data; Defect; ES cell; Embryo; Embryonic; Ensure; Environment; Eukaryota; Eukaryote; Family; Fibroblasts; Frequencies (time pattern); Frequency; Fusion Protein; GeneHomolog; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Goals; Hand; Harvest; Hereditary Disease; Homolog; Homologous Gene; Homologue; Human; Human, General; Knockout Mice; Knowledge; Laboratories; Lead; Life; Link; M Phase; M phase (cell cycle); Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Mitosis; Mitosis Stage; Mitotic/Spindle Checkpoint; Molecular; Molecular Disease; Molecular Interaction; Murine; Mus; Mutant Strains Mice; Mutation; Null Mouse; Pb element; Phenotype; Play; Predisposition; Premature aging syndrome; Pro-Metaphase; Prometaphase; RECQ4; RECQL4; RECQL4 gene; Role; Senescence; Senescence, Cellular; Senescence, Replicative; Severities; Sister Chromatid; Solid Neoplasm; Solid Tumor; Susceptibility; Syndrome; Testing; Therapeutic Intervention; Transgenic Mice; Upper arm; Western Blotting; Western Blottings; Western Immunoblotting; Work; anticancer therapy; base; cancer progression; cancer therapy; carcinogenesis; cell imaging; cellular imaging; cohesin; cohesion; embryonic stem cell; eukaryotida; experiment; experimental research; experimental study; genetic disorder; genome mutation; heavy metal Pb; heavy metal lead; helicase; hereditary disorder; intervention therapy; irradiation; malignancy; mouse model; mouse mutant; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; premature; protein blotting; research study; senescent; social role; stem cell of embryonic origin; tool; treatment strategy; tumor initiation; tumor progression","RecqL4, chromosome instability and cancer predisposition",,114535,CE,Cancer Etiology Study Section,,5,266285,
7758745,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA114569-05,,NCI:262148;,2010,NATIONAL CANCER INSTITUTE,,DUARTE,UNITED STATES,,32,027176833,US,CA,910103000,CITY OF HOPE/BECKMAN RESEARCH INSTITUTE,"CHU, FONG-FONG ;",8110941;,5R01CA114569,03/01/2006,01/31/2011,"Active Oxygen; Acute; Address; Affect; Age; Alleles; Allelomorphs; American; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Oncogenes; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioncogenes; Antioxidants; Apes; Attenuated; Bacteria; Bis(gamma-Glutamyl-L-cysteinylglycine) Disulfide; Bowel Cancer; Cancer Causing Agents; Cancer Gene Mutation; Cancer Induction; Cancers; Carcinogens; Causality; Chemicals; Chronic; Cola; Colon; Colon Cancer; Colon Carcinoma; Colonic Cancer; Colonic Carcinoma; Crohn's disease; Crohn's disorder; DNA Alteration; DNA mutation; Data; Disease; Disease model; Disorder; E. faecalis; E.faecalis; Emerogenes; Enteritis, Granulomatous; Enterococcus faecalis; Enzymes; Epithelial; Epithelium, Intestinal; Etiology; Exhibits; Family; Frequencies (time pattern); Frequency; GSSG; Gene Alteration; Gene Mutation; General Population; General Public; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Reporter; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetics-Mutagenesis; Genotoxins; Genus Cola; Germ-Free; Glutathione Disulfide; Glutathione, Oxidized; Glutathione[{..}]hydrogen-peroxide oxidoreductase; H2O2; Helicobacter; High-Risk Cancer; History; Housing; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; INFLM; Ileocolitis; Incidence; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Inorganic Sulfates; Intestinal; Intestinal Cancer; Intestinal Mucosa; Intestines; Intestines Cancer; Investigators; Isoenzymes; Isozymes; Lactobacillus casei rhamnosus; Lactobacillus rhamnosus; Lead; Malignant Colon Neoplasm; Malignant Colonic Neoplasm; Malignant Colonic Tumor; Malignant Intestinal Neoplasm; Malignant Intestinal Tumor; Malignant Neoplasm of the Intestine; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Intestine; Malignant tumor of colon; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Modeling; Molecular Biology, Mutagenesis; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Mutagenesis; Mutagens; Mutation; Mutation Spectra; N element; N2 element; NADPH Oxidase; Nitrogen; O element; O2 element; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogens; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen; Oxygen Radicals; P53; Pathogen Frees, Specific; Pathogenesis; Pathology; Patients; Pb element; Peroxidases; Play; Pongidae; Prevention; Pro-Oxidants; Probiotics; Programs (PT); Programs [Publication Type]; Reactive Oxygen Species; Recording of previous events; Reporter Genes; Research Personnel; Researchers; Role; S. faecalis; S.faecalis; Sequence Alteration; Sodium Dextran Sulfate; Specific Pathogen Frees; Streptococcus Group D; Streptococcus faecalis; Structure of intestinal epithelium; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Superoxide Anion; Superoxide Radical; Superoxides; Symptoms; TP53; TP53 gene; TRP53; Testing; Time; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Ulcerated Colitis; Ulcerative Colitis; Unspecified or Sulfate Ion Sulfates; Work; anti-oxidant; base; bowel; cancer risk; carcinogenesis; commensal bacteria; commensal microbes; dibenziodolium; diphenylene iodonium; diphenyleneiodonium; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; disorder model; electron acceptor; eleocolitis; experiment; experimental research; experimental study; genome mutation; genotoxic agent; germ free condition; glutathione peroxidase; granulomatous enterocolitis; great ape; heavy metal Pb; heavy metal lead; ileum; inhibitor; inhibitor/antagonist; insight; intestinal epithelium; malignancy; malignant colon tumor; model organism; mouse model; mutant; neoplasm/cancer; novel; oncosuppressor gene; pathogenic bacteria; prevent; preventing; programs; protective effect; regional enteritis; research study; selenoprotein; social role; specific pathogen free; sulfate",The role of glutathione peroxidase in the pathogenesis of intestinal cancer,,114569,ZRG1,Special Emphasis Panel,,5,262148,
7755355,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA115438-04,,NCI:249578;,2010,NATIONAL CANCER INSTITUTE,,IOWA CITY,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"DOMANN, FREDERICK E;",1866171;,5R01CA115438,04/01/2007,01/31/2012,"1,3-Bis(2-Chloroethyl)-1-Nitrosourea; 1H-1,2,4-Triazol-3-amine; 2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; 3-Amino-1,2,4-triazole; 3beta-Hydroxyandrost-5-en-17-one; 5-Androsten-3-beta-hydroxy-17-one; 6-Phospho-D-gluconate[{..}]NAD(P)+ 2-oxidoreductase; 6-Phosphogluconate Dehydrogenase; Abbreviations; Abscission; Active Oxygen; Affect; Aminotriazole; Amitrole; Androst-5-en-17-one, 3-hydroxy-, (3beta)-; Androstenolone; Antioxidants; BCNU; BSO; Bis(gamma-Glutamyl-L-cysteinylglycine) Disulfide; Bis-Chloronitrosourea; Breast; Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-; Buthionine Sulfoximine; Cancer Treatment; Cancer of Breast; Carmustine; Carmustine (BCNU); Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Chemicals; Complementary DNA; Copper; Cu element; CuZnSOD; D-Glucose; D-Glucose-6-phosphate[{..}]NADP+ 1-oxidoreductase; D-arabino-Hexose, 2-deoxy-; DHEA; DNA, Complementary; Data; Dehydroisoandrosterone; Deoxyglucose; Dextrose; EC 1.1.1.49; EC 1.14.13.39; EC 6.3.2.2; EDRF Synthase; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Ensure; Enzymes; Equilibrium; Erythrocuprein; Excision; Extirpation; FIVB; G6PD; GSSG; Gamma-Glutamylcysteine Synthetase; Gamma-Glutamylcysteinyl Synthetase; Generalized Growth; Genes; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Glucose; Glucose-6-Phosphate Dehydrogenase; Glucosephosphate Dehydrogenase; Glutamate-Cysteine Ligase; Glutamylcysteine Synthetase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Glutathione Synthetase; Glutathione, Oxidized; Glutathione, Reduced; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Growth; Guanylyl Cyclase-Activating Factor Synthase; H2O2; Hemocuprein; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Hydroperoxide; Infection; Inhibition of Cancer Cell Growth; Investigators; Knowledge; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Buthionine sulfoximine; L-Glutamate[{..}]L-cysteine gamma-ligase (ADP-forming); Location; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MDA MB 231; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Manganese; Manganese Superoxide Dismutase; Measures; Microcid; Mitochondria; Mn Superoxide Dismutase; Mn element; Mn-SOD; Molecular; Mononitrogen Monoxide; N element; N,N'-Bis(2-Chloroethyl)-N-Nitrosourea; N2 element; NADPH-Diaphorase; NADPH[{..}]oxidized-glutathione oxidoreductase; NO Synthase; Neoplasms of Neuroglia; Neuroglial Neoplasm; Neuroglial Tumor; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nitrosourea Compounds; Non-Malignant; Normal Cell; O element; O2 element; Organelles; Oxidation-Reduction; Oxygen; Oxygen Radicals; PH-GPeroxidase; PHGPx enzyme; Pathway interactions; Peroxidases; Phosphatides; Phosphogluconate Dehydrogenase; Phospholipids; Play; Prasterone; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Proteins; RNA, Small Interfering; Reactive Oxygen Species; Redox; Reduced Glutathione; Removal; Research; Research Personnel; Researchers; Role; S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine; S-(n-Butyl)homocysteine Sulfoximine; SOD; Signal Transduction Pathway; Small Interfering RNA; Specificity; Superoxide Anion; Superoxide Dismutase; Superoxide Radical; Superoxide[{..}]superoxide oxidoreductase; Superoxides; Surgical Removal; Therapeutic Dehydroepiandrosterone; Tissue Growth; Transfection; Triazoles; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Tumors of Neuroglia; U118; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Work; Zinc; Zn element; anti-oxidant; anticancer therapy; anticancer treatment; balance; balance function; base; beta-D-Glucose[{..}]oxygen 1-oxidoreductase; bis chloroethylnitrosourea; cDNA; cancer cell; cancer therapy; cancer type; catalase; cell type; clinical relevance; clinically relevant; copper zinc superoxide dismutase; cytocuprein; dehydroepiandrosterone; endothelial cell derived relaxing factor; experience; experiment; experimental research; experimental study; gamma-Glutamyl-Cysteine Synthetase; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gamma-L-Glutamyl-L-cysteine[{..}]glycine ligase (ADP-forming); gene product; glioma cell line; glucose oxidase; glutathione peroxidase; glutathione peroxidase GPX4; glutathione synthase; inhibitor; inhibitor/antagonist; malignant breast neoplasm; malignant phenotype; mitochondrial; nitrosourea; nonmalignant; ontogeny; oxidation reduction reaction; pathway; peroxiredoxin; peroxisome; phospholipid-hydroperoxide glutathione peroxidase; programs; protein expression; research study; resection; siRNA; social role; tumor; tumor suppressor",Molecular Species Responsible for Tumor Supressive Effect of MnSOD,,115438,CE,Cancer Etiology Study Section,,4,249578,
7774370,R01,CA,5,,02/01/2010,01/31/2011,PA-05-048,5R01CA115625-04,,NCI:346147;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"GOLDMAN, RADOSLAV ;",6835056;,5R01CA115625,02/15/2007,01/31/2011,"After Care; After-Treatment; Aftercare; Age; Arab Republic of Egypt; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Blood Serum; Cancer Screening for Patients; Cancer Staging; Cancers; Carcinoma of the Liver Cells; Chemoprevention; Chromatography; Chromatography / Separation Science; Chronic viral hepatitis; Cirrhosis; Classification; Collaborations; Country; Diagnostic; Diagnostic Neoplasm Staging; Disease; Disease Management; Disease Progression; Disorder; Disorder Management; EDRN; ELISA; Early Detection Research Network; Early Diagnosis; Egypt; Enzyme-Linked Immunosorbent Assay; Epidemic; Experimental Designs; Gender; Goals; HCC; HCV infection; Health; Hepatic Cancer; Hepatic Cirrhosis; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; High Throughput Assay; Isotopes; LC/MS; Label; Laboratories; Liver Cirrhosis; MALD-MS; MALDI; MALDI-MS; MALDI-TOF Mass Spectrometry; Malignant Conversion; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mass Spectrum; Mass Spectrum Analysis; Matrix-Assisted Laser Desorption Ionization Time-of-Flight MS; Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry; Methods; Molecular Weight; NANBH; National Detection Research Network; Neoplasm Staging; Newly Diagnosed; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Peptide Synthesis; Peptides; Performance; Photometry/Spectrum Analysis, Mass; Pilot Projects; Plasma; Population; Precancerous Conditions; Premalignant Condition; Premalignant State; Primary carcinoma of the liver cells; Proteins; Proteomics; Reticuloendothelial System, Serum, Plasma; Sampling; Scheme; Screening for cancer; Sensitivity and Specificity; Serum; Serum Proteins; Serum, Plasma; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Systematics; TXT; Testing; Text; Time; Tumor Staging; Ultrafiltration; Validation; Viral Diseases; Virus Diseases; aminoacid sequence of peptide; aminoacid sequence of protein; biomarker; case control; design; designing; disease/disorder; early cancer detection; early detection; gene product; hepatitis non A non B; hepatitis nonA nonB; high risk; high throughput screening; improved; interest; liquid chromatography mass spectrometry; liver cancer; magnetic beads; malignancy; malignant liver tumor; matrix assisted laser desorption ionization; neoplasm/cancer; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; peptide sequence; performance tests; pilot study; precancerous state; protein aminoacid sequence; reversed phase chromatography; viral infection; virus infection",Proteomic Analysis of Serum in Liver Cancer,,115625,CBSS,Cancer Biomarkers Study Section,,4,346147,
7753589,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA115717-04,,NCI:305900;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,UROLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"ABATE-SHEN, CORY ;",7755765;,5R01CA115717,04/01/2007,01/31/2012,"Abate; Ablation; Abscission; Adenocarcinoma; Adenoma, Malignant; Alleles; Allelomorphs; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Arts; Biological Models; Body Tissues; Cancer Induction; Cancer of Prostate; Cancers; Candidate Disease Gene; Candidate Gene; Castration; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Chemotherapy-Hormones/Steroids; Data; Disease; Disorder; EC 2.7.2-; Endocrine Gland Secretion; Epithelial Dysplasia; Epithelium; Epithelium of Human Prostate Gland; Equilibrium; Evolution; Excision; Expression Profiling; Expression Signature; Extirpation; Extracellular Signal-Regulated Kinases; FOS Family Genes; Future; Gene Deletion; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Generalized Growth; Generations; Genes; Genes, Homeo Box; Genes, Homeobox; Genes, fos; Genetic Condition; Genetic Diseases; Genital System, Male, Prostate; Growth; Growth and Development; Growth and Development function; HOX gene; Hereditary Disease; Homeobox Family Gene; Homeobox Genes; Homeodoamin Gene; Homeotic Genes; Hormones; Human; Human Prostate; Human Prostate Gland; Human, General; Individual; Intracellular Communication and Signaling; Intraepithelial Neoplasia; Intraepithelial Neoplasms; Investigation; Investigators; Lesion; MAP kinase; MAPK; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Adenocarcinoma; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Model System; Modeling; Models, Biologic; Molecular; Molecular Disease; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutant Strains Mice; Neoplasm Metastasis; Oncogenesis; Pathway interactions; Patients; Phenotype; Play; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Epithelium; Prostatic Gland; Receptor Signaling; Refractory; Refractory Disease; Removal; Research; Research Personnel; Researchers; Role; Secondary Neoplasm; Secondary Tumor; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Staging; Surgical Castration; Surgical Removal; Therapeutic Androgen; Therapeutic Hormone; Tissue Growth; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; Tumor Cell Migration; Tumor Suppressor Proteins; Validation; Work; androgen independent prostate cancer; balance; balance function; base; biological signal transduction; cancer metastasis; cancer progression; carcinogenesis; clinical significance; clinically significant; common treatment; cultured cell line; deprivation; disease/disorder; established cell line; gene deletion mutation; genetic disorder; hereditary disorder; hormone refractory prostate cancer; human disease; in vivo; in vivo Model; innovate; innovation; innovative; insight; loss of function; malignancy; men; men's; molecuar profile; molecular signature; mouse model; mouse mutant; mutant mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; next generation; novel; ontogeny; pathway; programs; prostate carcinogenesis; recombinase; resection; social role; tumor; tumor progression; tumor suppressor; tumorigenesis",Modeling androgen-independent prostate cancer in mutant mice,,115717,TCB,Tumor Cell Biology Study Section,,4,305900,
7762194,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA115883-04,,NCI:263567;,2010,NATIONAL CANCER INSTITUTE,,WEST LAFAYETTE,UNITED STATES,MISCELLANEOUS,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"LIU, SHUANG ;",7590960;,5R01CA115883,03/12/2007,01/31/2012,"Affinity; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Animal Model; Animal Models and Related Studies; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Arg-Gly-Asp; Arginine-Glycine-Aspartic Acid Cell Adhesion Domain; Astrocytoma, Grade IV; Athymic Nude Mouse; Binding; Binding (Molecular Function); Biological; Bone Sarcoma; Breast; Breast Cancer Early Detection; Breast Cancer Early Screening; Breast Neoplasms; Breast Tumors; Cancer Patient; Cancer Radiotherapy; Cancer of Bladder; Cancer of Breast; Cancer of Urinary Bladder; Cause of Death; Chelating Agents; Chelators; Clinical Evaluation; Clinical Testing; Complex; Complexons; Detection; Development; Diagnosis; Dissociation; Dose; Drug Kinetics; Early Diagnosis; Evaluation; Extracellular Matrix, Integrins; Future; Generalized Growth; Genital System, Male, Prostate; Glioblastoma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Heterograft; Human; Human Prostate; Human Prostate Gland; Human, General; Image; In Vitro; Individual; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Integrins; Isomerism; Kidney; Kinetic; Kinetics; Label; Lesion; Liver; Malignant Bladder Neoplasm; Malignant Melanoma; Malignant Tumor of the Bladder; Malignant Tumor of the Breast; Malignant neoplasm of breast; Malignant neoplasm of urinary bladder; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice, Athymic; Mice, Nude; Modeling; Molecular Interaction; Monitor; Neoplasm Metastasis; Neovascularization Inhibitors; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Nude Mice; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Osseous Sarcoma; Ovarian; Patient Rights; Patients; Peptides; Pharmacokinetics; Physicians; Primary Neoplasm; Primary Tumor; Prostate; Prostate Gland; Prostatic Gland; RGD; RGD (peptide); RGD (sequence); RGD Cell Adhesion Domain; RGD Domain; RGD Motif; RGD Tripeptide Sequence; RGD tripeptide; Radiation therapy; Radiopharmaceutical Compound; Radiopharmaceuticals; Radiotherapeutics; Radiotherapy; Receptor Protein; SCHED; Sarcoma, Osteogenic; Schedule; Secondary Neoplasm; Secondary Tumor; Skeletal Sarcoma; Solid Neoplasm; Solid Tumor; Solutions; Specificity; Staging; Surgical; Surgical Interventions; Surgical Procedure; Therapeutic; Tissue Growth; Transplantation, Heterologous; Treatment Efficacy; Tumor Cell; Tumor Cell Migration; Urinary Bladder Malignant Tumor; Urinary System, Kidney; Woman; Xenograft; Xenograft procedure; Xenotransplantation; animal model selection; antiangiogenic; arginyl-glycyl-aspartic acid; base; body system, hepatic; cancer diagnosis; cancer imaging; cancer metastasis; chemotherapy; clinical test; design; designing; dimer; early detection; glioblastoma multiforme; imaging; improved; in vivo; irradiation; isomer; lung Carcinoma; malignant breast neoplasm; mammary tumor; melanoma; model organism; neoplastic cell; neovasculature; novel; ontogeny; organ system, hepatic; osteochondrosarcoma; osteoid sarcoma; osteosarcoma; overexpression; pre-clinical; preclinical; radioactive drugs; radiolabel; radiotracer; receptor; receptor binding; renal; research clinical testing; spongioblastoma multiforme; surgery; therapeutic efficacy; therapeutically effective; tumor; tumor growth; uptake",TC-Labeled Cyclic RGDfK Tetramers for Breast Cancer Imaging,,115883,MEDI,Medical Imaging Study Section,,4,263567,
7763909,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA115902-05,,NCI:254739;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,OTOLARYNGOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"FERRIS, ROBERT L;",1904238;,5R01CA115902,04/21/2006,02/28/2011,"(SP-4-2)-Diamminedichloroplatinum; Address; Apoptosis; Apoptosis Pathway; Apoptotic; Autocrine Systems; Biological Models; CC chemokine receptor 7; CC chemokine receptor CCR7; CCL19; CCL19 gene; CCL21; CCL21 gene; CCR7 protein; CDDP; CKb11; CKb9; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Survival; Cell Viability; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cellular Migration; Cervical Lymph Node; Cervical lymph node group; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical; Cysplatyna; Cytokines, Chemotactic; DDP; Data; Development; Dichlorodiammineplatinum; Disease; Disorder; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; General Prognostic Factor; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HER1; HNSCC; Head and Neck; Head and Neck Cancer; Head and Neck Carcinoma; Head and Neck Neoplasm (Excluding Central Nervous System); Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Homing; Homologous Chemotactic Cytokines; Human; Human, General; IHC; Immune; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inflammatory; Intercrines; Intracellular Communication and Signaling; Lead; Lecithinase C; Ligands; Link; Lymph node proper; Lymphoid; MGC34433; MGC34555; MIP; MIP-3b; MIP3B; Macrophage Inflammatory Proteins; Malignant Head and Neck Neoplasm; Malignant Tumor of the Head and Neck; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasis to Lymph Nodes; Metastasize; Metastatic Neoplasm; Metastatic Neoplasm to Lymph Nodes; Metastatic Squamous Cell Carcinoma; Metastatic Tumor; Metastatic Tumor to Lymph Nodes; Mice; Model System; Modeling; Models, Biologic; Motility; Motility, Cellular; Murine; Mus; Neoplasm Metastasis; Nonmetastatic; Organ; Outcome; Pathway interactions; Patients; Pb element; Peyrone's Chloride; Peyrone's Salt; Phenotype; Phospholipase C; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Prognostic Factor; Prognostic/Survival Factor; Receptor Inhibition; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Regimen; Reporting; Research Design; Research Specimen; Resistance; Reticuloendothelial System, Lymph Node; Role; SCCHN; SCYA19; SCYA21; SIS cytokines; SLC; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specimen; Squamous Cell Epithelioma; Squamous cell carcinoma; Study Type; TCA4; Testing; Therapeutic; Transforming Growth Factor alpha Receptor; Tumor Cell; Tumor Cell Line; Tumor Cell Migration; Tumor of the Head and Neck; Up-Regulation; Up-Regulation (Physiology); Upregulation; autocrine; biological signal transduction; biomarker; c-erbB-1; c-erbB-1 Protein; cancer metastasis; cancer progression; cell motility; chemoattractant cytokine; chemokine; chemokine receptor; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; cultured cell line; cytokine; disease/disorder; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; head & neck cancer; head & neck tumor; head and neck tumor; heavy metal Pb; heavy metal lead; improved; in vivo; intervention design; lipophosphodiesterase I; lymph gland; lymph nodes; migration; neoplasm progression; neoplastic cell; neoplastic progression; new therapeutic target; novel; overexpression; paracrine; pathway; phosphatidylcholine cholinephosphohydrolase; pre-clinical; preclinical; prevent; preventing; prognostic; proto-oncogene protein c-erbB-1; receptor; receptor 7, chemokine; resistant; small molecule; social role; study design; therapeutic target; therapy design; treatment design; tumor; tumor growth; tumor progression",Chemokine Signals in Head and Neck Cancer Progression,,115902,DT,Developmental Therapeutics Study Section,,5,254739,
7758208,R01,CA,5,,02/01/2010,01/31/2011,PA-05-086,5R01CA115992-04,,NCI:305900;,2010,NATIONAL CANCER INSTITUTE,,OAKLAND,UNITED STATES,,09,076536184,US,CA,94609,CHILDREN'S HOSPITAL & RES CTR AT OAKLAND,"EPSTEIN, ERVIN H;",1866447;,5R01CA115992,04/01/2007,01/31/2012,"Address; BCC; Basal cell carcinoma; Basiloma; Biology; Body Tissues; Cancer Induction; Cancer stem cell; Cancers; Carcinoma, Basal Cell, Pigmented; Cells; Epithelioma, Basal Cell; Funding; Goals; Human; Human, General; Knowledge; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Mammals, Mice; Man (Taxonomy); Man, Modern; Melanoma and Non-Melanoma Skin Cancer; Methods and Techniques; Methods, Other; Mice; Mother Cells; Murine; Mus; Oncogenesis; Process; Progenitor Cells; Research; Skin; Skin Basal Cell Carcinoma; Skin Cancer; Skin Cancer, Including Melanoma; Stem cells; Techniques; Time; Tissues; Ulcer, Rodent; base; carcinogenesis; design; designing; experiment; experimental research; experimental study; in vivo; insight; interest; malignancy; mouse model; neoplasm/cancer; research study; self-renewal; tool; tumorigenesis",Biology of Basal Cell Carcinomas,,115992,ZRG1,Special Emphasis Panel,,4,305900,
7755814,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116019-04,,NCI:292084;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"AKHURST, ROSEMARY J;",6104534;,5R01CA116019,05/01/2007,01/31/2011,"Affect; Alleles; Allelomorphs; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Body Tissues; Bone-Derived Transforming Growth Factor; CED; Cancer Drug; Cancer Treatment; Cancer of Breast; Cancers; Candidate Disease Gene; Candidate Gene; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chemotherapeutic Agents, Neoplastic Disease; Chromosome 12; Chromosome 7; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 7; Clinical Trials; Clinical Trials, Unspecified; Custom; DISSEC; DPD1; Data; Development; Dissection; Disseminated Malignant Neoplasm; Drugs; Environment; Gene Expression; Generalized Growth; Genes; Genetic; Genetic Polymorphism; Genetics, Human; Genomics; Goals; Growth; Human; Human Genetics; Human, General; INFLM; Immune Surveillance; Immunologic Surveillance; Immunological Surveillance; Inflammation; Intracellular Communication and Signaling; Investigation; Knockout Mice; Knowledge; Learning; Linkage Analysis; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Skin; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Medication; Medicine; Melanoma and Non-Melanoma Skin Cancer; Metastatic Cancer; Metastatic Malignant Neoplasm; Methods; Mice; Mice, Knock-out; Mice, Knockout; Milk Growth Factor; Molecular; Molecular Mechanisms of Action; Murine; Mus; NIH Mouse; Null Mouse; Oncogenesis; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Platelet Transforming Growth Factor; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Predisposition; Predisposition gene; Process; Recombinants; Relative; Relative (related person); Resistance; Risk; Risk Assessment; Rosemary; SNP; SNPs; Sampling; Science of Medicine; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Skin Neoplasms; Solid; Surveillances, Immunologic; Surveillances, Immunological; Susceptibility; Susceptibility Gene; TGF B; TGF-beta; TGFB; TGFB1; TGFB1 gene; TGFbeta; Testing; Tissue Growth; Tissues; Transforming Growth Factor beta; Tumor Angiogenesis; Tumor Cell; Tumor of the Skin; Tumor-Specific Treatment Agents; Validation; Variant; Variation; Woman; Work; anticancer agent; anticancer drug; anticancer therapy; association test; biological signal transduction; cancer progression; cancer risk; cancer therapy; case control; cell type; clinical investigation; combinatorial; congenic; design; designing; drug development; drug/agent; family based linkage study; genetic association; genetic linkage analyses; genetic linkage analysis; in vitro activity; in vivo; inhibitor; inhibitor/antagonist; linkage analyses; malignancy; malignant breast neoplasm; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; ontogeny; pathway; polymorphism; predisposing gene; resistant; screening; screenings; tool; tumor; tumor progression; tumorigenesis","""Genetic interactions between Tgfb1 and Skts15/Tgfbm3 in cancer""",,116019,CG,Cancer Genetics Study Section,,4,292084,
7755005,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116020-05,,NCI:338027;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"MEYERSON, MATTHEW L;",1929097;,5R01CA116020,03/24/2006,01/31/2011,"3-D structure; 3-dimensional structure; 3D structure; 4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-4-morpholin] propoxy]; Address; Anthelone U; Assay; Astrocytoma, Grade IV; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cancer Cause; Cancer Etiology; Cancer Treatment; Cancer of Lung; Cancers; Carcinoma, Non-Small-Cell Lung; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cessation of life; Clinical; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; DNA Alteration; DNA mutation; Data; Death; Development; EC 2.7; EGF; EGFR; ERBB Protein; ERBB1; Enzyme Kinetics; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor-Urogastrone; Erlotinib; Exons; External Domain; Extracellular Domain; Gefitinib; Gene Alteration; Gene Mutation; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetics-Mutagenesis; Glioblastoma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; HER1; Human; Human Urinary Gastric Inhibitor; Human, General; Imatinib; In Vitro; Investigators; Iressa; Kinases; Lead; Lung Adenocarcinoma; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Molecular Biology, Mutagenesis; Mortality; Mortality Vital Statistics; Mutagenesis; Mutagenesis, Site-Directed; Mutate; Mutation; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; NIH 3T3 Cells; NIH/3T3; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; PTK Inhibitors; Patient Selection; Patients; Pb element; Phosphorylation; Phosphotransferases; Point Mutation; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Tyrosine Kinase Inhibitors; Pulmonary Cancer; Pulmonary malignant Neoplasm; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Receptor Tyrosine Kinase Gene; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Relapse; Research Personnel; Researchers; Resistance; Resistance development; Resistant development; Roentgen Rays; Sequence Alteration; Single Crystal Diffraction; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Somatic Mutation; Structure; TK Inhibitors; Tarceva; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Transforming Growth Factor alpha Receptor; Transphosphorylases; Tumor-Derived; Tyrosine Kinase Inhibitor; Tyrosine Phosphorylation Site; United States; Urogastrone; Work; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; anticancer therapy; base; beta-Urogastrone; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer therapy; cell growth; cell transformation; developing resistance; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; genome mutation; glioblastoma multiforme; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; kinase inhibitor; lung cancer; malignancy; mutant; neoplasm/cancer; nonsmall cell lung cancer; programs; proto-oncogene protein c-erbB-1; resistance mechanism; resistance mutation; resistant; resistant mechanism; response; small molecule; spongioblastoma multiforme; three dimensional structure; transformed cells; tumor",Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma,,116020,ZRG1,Special Emphasis Panel,,5,338027,
7804541,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116042-04,,NCI:242820;,2010,NATIONAL CANCER INSTITUTE,,NEW ORLEANS,UNITED STATES,BIOCHEMISTRY,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"VEDECKIS, WAYNE V.;",1887582;,5R01CA116042,04/01/2007,01/31/2012,"ALL - Acute Lymphocytic Leukemia; Acute Lymphoid Leukemia; Acute T Cell Leukemia; Affect; Alternate Splicing; Alternative Splicing; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Autoregulation; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blast Cell; Blasts; Blood (Leukemia); Cell Death, Programmed; Cells; Chemotherapy-Hormones/Steroids; Diagnosis; Diagnostic; Down-Regulation; Down-Regulation (Physiology); Downregulation; Endocrine Gland Secretion; Exhibits; Exons; Family; Ferrata cell; Figs; Figs - dietary; Gene Transcription; Genetic Transcription; Glucocorticoid Receptor; Glucocorticoids; Hematohistioblast; Hemocytoblast; Hemohistioblast; Homeostasis; Hormonal; Hormone Responsive; Hormones; Human; Human, General; Laboratories; Lead; Leukemia, Lymphocytic, Acute; Leukemias, General; Ligands; Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Acute, T-Cell; Lymphocytic Leukemia, T-Cell, Acute; Lymphoid Cell; MYB; MYB gene; Man (Taxonomy); Man, Modern; Mediating; Molecular; Molecular Interaction; Multiple Myeloma; Myeloma, Plasma-Cell; NF-JB protein; NFIL-1betaA protein; NFbetaA protein; Nuclear; PU.1 Transcription Factor; Pathway interactions; Patients; Pb element; Physiological Homeostasis; Population; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Precursor T Lymphoblastic Leukemia; Precursor T-Lymphoblast; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proto-Oncogene Products c-myb; Proto-Oncogene Proteins c-myb; Pu-1 protein; RNA Expression; RNA Splicing, Alternative; RT-PCR; RTPCR; Receptor Gene; Receptor Protein; Regulation; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Role; SPI1; SPI1 Gene Product; SPI1 Protein; Sampling; Spi-1; Steroid Compound; Steroid therapy; Steroids; Stratification; T-Cell Type Acute Leukemia; T-Lymphoblast; T-Lymphocytic Leukemia, Acute; Testing; Therapeutic Glucocorticoid; Therapeutic Hormone; Therapeutic Steroid Hormone; Transcript; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Up-Regulation; Up-Regulation (Physiology); Upregulation; V-Myb Myeloblastosis Viral Oncogene Homolog; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; c myb; c-Myb; c-Spi-1 protein; c-myb Gene; c-myb Proteins; c-myb Proto-Oncogenes; cell type; chemotherapy; ets proto-oncogene proteins; gene product; heavy metal Pb; heavy metal lead; improved; lambda Spi-1; leukemia; lymphoblast; member; myb Proto-Oncogene Proteins; myeloma; myelomatosis; pathway; protein c-ets; protein expression; proto-oncogene protein Spi-1; proto-oncogene proteins c-ets; receptor; resistant; response; reverse transcriptase PCR; social role; steroid hormone; steroid hormone receptor; transcription factor; translational approach",Glucocorticoid Receptor Regulation in Leukemia,,116042,MCE,Molecular and Cellular Endocrinology Study Section,,4,242820,
7762190,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116184-04,,NCI:311600;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KURMAN, ROBERT J.;",2006948;,5R01CA116184,04/01/2007,01/31/2011,"ATP-protein phosphotransferase; Active Follow-up; Age; Allelic Imbalance; Area; Artifacts; Assay; B-raf-1; BRAF; BRAF gene; Base Sequence; Behavior; Benign; Bioassay; Biologic Assays; Biological Assay; Borderline Neoplasm; Borderline tumor; C-K-RAS; Cancer Staging; Cancer of the Ovary; Carcinoma; Causality; Cell Communication and Signaling; Cell Signaling; Characteristics; Classification; Clinical; Clinical Management; Clonality; Color; Computer Assisted; DNA; DNA copy number; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Denmark; Deoxyribonucleic Acid; Development; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Disease; Disorder; EC 2.7; ERBB2; ERBB2 gene; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epithelium; Etiology; Experimental Designs; Expression Profiling; Expression Signature; FISH Technic; FISH Technique; FISH analysis; Fluorescent in Situ Hybridization; Forecast of outcome; Future; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic analyses; Genetic defect; Genital System, Female, Ovary; Genomics; Gynecologic; HER -2; HER-2; HER2; HER2/neu; Histologic; Histologically; Human; Human EGF Receptor 2 Gene; Human, General; Implant; In Situ Hybridization, Fluorescence; Intracellular Communication and Signaling; Investigators; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Kinases; Label; Lesion; Lyonization; Malignant; Malignant - descriptor; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Man (Taxonomy); Man, Modern; Measures; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Microscopic; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Marker of Prognosis; Molecular Profiling; Morphologic artifacts; Mutation; Mutation Analysis; Nature; Neoplasm Metastasis; Neoplasm Staging; Neoplasm of Borderline Malignancy; Neoplasm of Low Malignant Potential; Neoplasm of Uncertain Malignant Potential; Neoplasms; Nuclear; Nucleotide Sequence; Oncogene K-Ras; Oncogene, K-Ras-2; Outcome; Outcome Study; Ovarian; Ovarian Tumor; Ovary; Ovary Neoplasms; Paraffin; Paraffin Tissue; Paraffin waxes and Hydrocarbon waxes; Pathogenesis; Pathologist; Pathology; Patients; Pattern; Peritoneal; Peritoneal Neoplasms; Phosphotransferases; Play; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population-Based Registry; Principal Investigator; Prognosis; Prognosis Marker; Prognostic Marker; Protein Kinase; RAFB1; RASK2; Recurrence; Recurrent; Registries; Reporting; Reproducibility; Research Personnel; Researchers; Role; SNP; SNPs; Sampling; Secondary Neoplasm; Secondary Tumor; Selection Bias; Serous; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Slide; Somatic Mutation; Staging; Study, Outcome; Systematics; T-Stage; TKR1; Technology; Testing; Therapeutic; Time; Tissue, Paraffin; Transphosphorylases; Tumor Cell Migration; Tumor Staging; Tumor of the Ovary; Tumor stage; Tumors; Woman; X Inactivation; X-Chromosome Inactivation; base; biological signal transduction; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer metastasis; cancer progression; clinical data repository; clinical data warehouse; computer aided; data repository; digital; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; epithelial carcinoma; follow-up; genetic analysis; genome mutation; genome-wide; glycogen synthase a kinase; hydroxyalkyl protein kinase; indexing; inhibitor; inhibitor/antagonist; molecuar profile; molecular marker; molecular signature; neoplasia; neoplasm progression; neoplastic; neoplastic growth; neoplastic progression; novel; nucleic acid sequence; outcome forecast; ovarian cancer; ovarian neoplasm; peritoneum neoplasm; phosphorylase b kinase kinase; polymorphism; population based; prognostic indicator; relational database; small molecule; social role; tertiary care; tool; tumor; tumor progression; tumor registry; uncertain malignant potential neoplasm; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; v-raf Murine Sarcoma Viral Oncogene Homolog B1",Pathogenesis of Ovarian Serous Borderline Tumors,,116184,CG,Cancer Genetics Study Section,,4,311600,
7786274,R01,CA,5,,03/01/2010,02/28/2011,PAS-05-092,5R01CA116235-05,,NCI:294724;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"POLYAK, KORNELIA ;",6808814;,5R01CA116235,04/01/2006,02/28/2011,"0-11 years old; AREG; AREG gene; Acute; Amphiregulin Gene; Basket Cell; Benign Myoepithelioma; Biological Models; Breast; Breast Cancer Treatment; Breast Carcinoma; Breast Neoplasms; Breast Tissue; Breast Tumors; CRDGF; CTGF; CXCL12; CXCL12 gene; Cancer of Breast; Cancers; Carcinoma; Carcinoma, Intraductal; Cell Communication; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell-to-Cell Interaction; Cells; Child; Child Youth; Children (0-21); Co-culture; Cocultivation; Coculture; Coculture Techniques; Conditioned Culture Media; Conditioned Medium; Culture Media, Conditioned; DCIS; DNA Methylation; Data; Ductal Breast Carcinoma In Situ; Ductal Carcinoma In Situ; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Fibroblasts; GDF-15; GDF15; GDF15 gene; Gene Expression; Generalized Growth; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, Karyotyping; Goals; Growth; Heterograft; Histology; Human; Human, Child; Human, General; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; In Situ; In Vitro; Injection of therapeutic agent; Injections; Intraductal Carcinoma of the Breast; Investigators; Karyotype determination procedure; Karyotyping; Lead; MGC13647; MIC-1; MIC1; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant lymphoid neoplasm; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Carcinoma; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Methods; Methylation; Mice; Model System; Modeling; Models, Biologic; Morphology; Mother Cells; Murine; Mus; Mutation; Myoepithelial; Myoepithelial Neoplasm; Myoepithelial Tumor; Myoepithelial cell; Myoepithelioma; NAG-1; Non-Infiltrating Ductal Breast Adenocarcinoma; Non-Infiltrating Ductal Carcinoma of the Breast; Non-Infiltrating Intraductal Adenocarcinoma; Non-Infiltrating Intraductal Breast Adenocarcinoma; Non-Infiltrating Intraductal Carcinoma; Non-Invasive Ductal Breast Adenocarcinoma; Non-Invasive Ductal Carcinoma of the Breast; Non-Invasive Intraductal Breast Adenocarcinoma; Noninfiltrating Intraductal Carcinoma; Oncogenesis; PBSF; PDF; PLAB; PLAB Gene; PTGFB; Pathologic; Pattern; Pb element; Phenotype; Physiologic; Physiological; Play; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Methylation; Proteins; Research Personnel; Researchers; Role; SCYB12; SDF-1A; SDF-1B; SDF1; SDF1A; SDF1B; SDGF; Stem cells; Stromal Cells; Stromal Neoplasm; Stromal Tumor; System; System, LOINC Axis 4; TLSF-A; TLSF-B; TPAR1; Time; Tissue Growth; Transplantation, Heterologous; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; base; breast tumorigenesis; cancer progression; cell type; children; connective tissue growth factor; digital; epithelial carcinoma; experiment; experimental research; experimental study; fisp12 protein; gene product; genetic profiling; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; in vitro Model; in vivo; insulin-like growth factor binding protein 8; lymphoid malignancy; malignancy; malignant breast neoplasm; mammary; mammary gland development; mammary tumor; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; ontogeny; overexpression; paracrine; progenitor; programs; research study; serial analysis of gene expression; social role; tumor; tumor growth; tumor progression; tumor xenograft; tumorigenesis; youngster",Epithelial-stromal cell interactions in breast cancer,,116235,TME,Tumor Microenvironment Study Section,,5,294724,
7764747,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116402-04,,NCI:363850;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"HUNTER, TONY R.;",1870222;,5R01CA116402,04/03/2007,01/31/2012,"(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4'[{..}]6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano(3',4'[{..}]6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI); 20-(S)-camptothecine; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21, 22-secocamptothecin-21-oic acid lactone; APF-1; ATM activation; ATM kinase; ATM protein kinase; ATP-Dependent Proteolysis Factor 1; ATR; ATR protein kinase; Alkylating Agents; Alkylators; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Area; Ataxia Telangiectasia and Rad3 Related Protein; Ataxia-Telangiectasia-Mutated protein kinase; Attention; Biochemical; Biological; Camptothecin; Cancer Biology; Cancer Cause; Cancer Drug; Cancer Etiology; Cancer Patient; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Nucleus; Cell Respiration; Cell Signaling; Cell Survival; Cell Viability; Cell division; Cells; Cellular Respiration; Checkpoint kinase 1; Chemotherapeutic Agents, Neoplastic Disease; Chromosome Segregation; Chromosomes; Clinic; Clinical; Collaborations; Complement; Complement Proteins; Complex; DNA; DNA Damage; DNA Double Strand Break; DNA Helicases; DNA Injury; DNA Recombination; DNA Repair Pathway; DNA Replication; DNA Synthesis; DNA Topoisomerase Inhibitors; DNA Unwinding Proteins; DNA biosynthesis; DNA recombination (naturally occurring); DNA replication fork; DNA unwinding enzyme; Data; Defect; Degradation Pathway; Degradative Pathway; Deoxyribonucleic Acid; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Electromagnetic Radiation, Ionizing; Environment; Enzymes; Eukaryote; Eukaryotic Cell; Event; Evolution; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FLR; FRAP-Related Protein-1; FRAP1 protein, human; FRP1; Failure (biologic function); Fission Yeast; Generalized Growth; Genetic; Genetic Recombination; Genome; Genotoxic Stress; Genotoxins; Growth; HMG-20; High Mobility Protein 20; Human; Human, General; Hypoxia; Hypoxic; IGF-1 Receptor; IGF1R; Insulin-Like Growth Factor 1 Receptor; Insulin-Like-Growth Factor I Receptor; Intermediary Metabolism; Intervening Protein Sequence; Intracellular Communication and Signaling; Investigation; Investigators; Ionizing radiation; Kinases; Laboratories; Lead; Lesion; Ligase; Lymphocytes, Null; Lytotoxicity; METBL; Macropain; Macroxyproteinase; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Medication; Metabolic Processes; Metabolic stress; Metabolism; Mitosis Checkpoint; Mitotic Checkpoint; Mitotic Chromosome; Molecular; Monitor; Mothers; Movement; Multicatalytic Proteinase; Mutagens; Nature; Nucleus; Null Cells; Null Lymphocytes; Outcome; Oxygen Deficiency; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTPA; Paper; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphorylation; Phosphotransferases; Phosphotyrosyl Phosphatase Activator; Predisposition; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Introns; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Phosphorylation; Proteins; Proteosome; Publishing; RAFT1 protein, human; RAPT1 protein, human; Rad3 Related Protein; Radiation-Ionizing Total; Radio; Rapamycin Target Protein; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Recombination; Recombination, Genetic; Recovery; Regulation; Replication Process; Replication-Associated Process; Research; Research Personnel; Researchers; Resistance; Resistance development; Resistant development; Role; S pombe; Schizosaccharomyces pombe; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stress; Stress, Genotoxic; Susceptibility; Synthetases; System; System, LOINC Axis 4; Therapeutic; Therapeutic Agents; Therapeutic Index; Tissue Growth; Topoisomerase Inhibitors; Transphosphorylases; Tumor Cell; Tumor-Specific Treatment Agents; Ubiquitilation; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Work; Xenopus; Yeast, Fission; activation, Atm; activator of DNA replication; aerobic metabolism; aerobic respiration; anticancer agent; anticancer drug; assault; base; biological adaptation to stress; biological signal transduction; body movement; cancer cell; cell killing; chk1 kinase; chk1 protein kinase; cytotoxic; cytotoxicity; daughter cell; developing resistance; drug discovery; drug/agent; egg; eukaryotida; experience; failure; gene product; genotoxic agent; heavy metal Pb; heavy metal lead; helicase; histone modification; human FRAP1 protein; insight; intein; interest; mTOR; malignancy; multicatalytic endopeptidase complex; necrocytosis; neoplasm/cancer; neoplastic cell; novel; ontogeny; oxidative metabolism; pathway; prevent; preventing; programs; rapamycin and FKBP12 target 1 protein, human; reaction; crisis; repair; repaired; resistant; response; social role; stress response; stress; reaction; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",Checkpoint Kinase Chk1 in Cancer Biology and Therapy,,116402,CE,Cancer Etiology Study Section,,4,363850,
7759506,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116444-05,,NCI:279300;,2010,NATIONAL CANCER INSTITUTE,,AUGUSTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"HE, YUKAI ;",6185821;,5R01CA116444,04/01/2007,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 3,4-dihydroxyphenylalaninechrome tautomerase; APF-1; ATGN; ATP-Dependent Proteolysis Factor 1; Administration, Cutaneous; Antigen Presentation; Antigen Processing; Antigen Processings; Antigenic Determinants; Antigens; Autocrine Systems; Binding Determinants; Blood; CD8; CD8B; CD8B1; CD8B1 gene; Cancers; Cells; Clinical; Cross Presentation; Cross-Priming; Cutaneous Administration; Cutaneous Drug Administration; Data; Degradation Pathway; Degradative Pathway; Dendritic Cells; Dermal; Dermal Administration; Development; Dopachrome isomerase; Drug Administration, Dermal; Effectiveness; Effector Cell; Engineering; Engineerings; Epitopes; Fc Fragments; Fc Immunoglobulins; Fc Receptor; FcR; Future; Generations; Goals; HMG-20; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesvirus hominis; High Mobility Protein 20; ITX; Immune; Immune response; Immune system; Immunity; Immunization; Immuno-Chemotherapy; Immunochemotherapy; Immunoglobulins, Fc; Immunologic Stimulation; Immunological Stimulation; Immunologically Directed Therapy; Immunostimulation; Immunotherapy; Immunotherapy, Cancer, General; In Vitro; Infectious Skin Diseases; Influenza Virus; Interphase Cell; Invaded; Knowledge; LYT3; Langerhans cell; Macropain; Macroxyproteinase; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Microbe; Modality; Modeling; Multicatalytic Proteinase; Murine; Mus; Non-dividing Cell; Pathway interactions; Pattern recognition receptor; Population; Poxvirus officinale; Preventive; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteosome; Resting Cell; Reticuloendothelial System, Blood; Role; Sensitization, Immunologic; Sensitization, Immunological; Simplexvirus; Skin; Skin Diseases, Infectious; Skin Drug Administration; Stimulus; T-Cells; T-Lymphocyte; TLR protein; TRP-2; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Toll-like receptors; Tumor Antigens; Tumor-Associated Antigen; Tyrosinase-Related Protein-2; Ubiquitin; Vaccines; Vaccinia virus; Veiled Cells; Viral Diseases; Virus Diseases; antibody receptor; antigen processing; autocrine; base; body system, allergic/immunologic; cancer immunotherapy; design; designing; dopachrome conversion factor; dopachrome oxidoreductase; dopachrome tautomerase; genetic immunization; genetic immunization strategies; herpesvirus; host response; human herpesvirus 1 group; immune therapy; immunogen; immunoresponse; improved; in vivo; influenzavirus; influenzavirus (unspecified); malignancy; melanoma; multicatalytic endopeptidase complex; neoplasm/cancer; organ system, allergic/immunologic; paracrine; pathway; protein degradation; recombinant vaccinia virus; response; skin infection; social role; thymus derived lymphocyte; tumor; tumor-specific antigen; uptake; viral infection; virus infection",Mechanism of Eliciting Antitumor Cell Immunity Via Lentivector Immunization,,116444,ZRG1,Special Emphasis Panel,,5,279300,
7758838,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA116753-05,,NCI:281797;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SWEASY, JOANN B;",8183234;,5R01CA116753,04/01/2006,01/31/2011,"Allelic Loss; Aspartic Acid; Base Excision Repairs; Biochemical; Birth Defects; Body Tissues; Cancers; Cells; Chromosomal Rearrangement; Chromosome Pairing; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA Base Excision Repair; DNA Polymerase IV; DNA Polymerase beta; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA strand break; Disease; Disorder; Double Strand Break Repair; Egg, Unfertilized; Female; Frequencies (time pattern); Frequency; Gametes; Gametogenesis; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetics-Mutagenesis; Genital System, Female, Fluids, Secretions, Ova; Genital System, Male, Testis; Genome; Genome Instability; Genome Stability; Genomic Instability; Germ; Germ Cells; Germ Lines; Germ-Line Cells; Grant; Haploid; Haploidy; L-Aspartic Acid; Lead; Loss of Heterozygosity; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Mediating; Meiosis; Meiotic Recombination; Methods; Methods and Techniques; Methods, Other; Mice; Miscarriage; Molecular Biology, Mutagenesis; Molecular Genetic Abnormality; Mother Cells; Murine; Mus; Mutagenesis; Mutation; Mutation Spectra; Ova, Fluids, Secretions; Ovum; Pb element; Point Mutation; Polymerase; Polymorphism (Genetics); Polymorphism, Genetic; Primordial Germ Cell; Process; Progenitor Cells; Proteins; Repairs, Base Excision; Reproductive Cells; Research; Role; Seminiferous Tubules; Seminiferous tubule structure; Sex Cell; Sperm; Spermatozoa; Spontaneous abortion; Stability, Genomic; Stem cells; Sterility; Structure of primordial sex cell; Synapsis; Synapsis, Chromosomal; System; System, LOINC Axis 4; Targetings, Gene; Techniques; Testicles; Testing; Testis; Tissues; Transgenes; Whole Organism; cancer progression; disease/disorder; egg/ovum; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; initial cell; male; malignancy; meiotic; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; polymorphism; protein complex; repair; repaired; research study; sexual cell; social role; sperm cell; sterile; tumor progression; zoosperm",Characterization of a DNA polymerase Beta deficient mouse,,116753,ZRG1,Special Emphasis Panel,,5,281797,
7777297,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA116813-05,,NCI:256806;,2010,NATIONAL CANCER INSTITUTE,,AUSTIN,UNITED STATES,BIOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"DUDLEY, JAQUELIN PAGE;",1881715;,5R01CA116813,04/01/2006,02/28/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Affinity Chromatography; Assay; Avian Leukosis; Betaretrovirus; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Bittner Virus; C-terminal; Cell Differentiation; Cell Differentiation process; Cell Nucleus; Cells; Chromatography, Affinity; Complement; Complement Proteins; Complex; Data; Deoxynucleotide-triphosphate[{..}]DNA deoxynucleotidyltransferase (RNA-directed); Development; Disease; Disorder; EC 2.7.7.49; Elements; Esteroproteases; Export, Nuclear; Family member; Gagging; Gene Products, RNA; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome; HERVs; HIV; HTLV Viruses; HTLV-III; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Leukemia Viruses; Human T-Cell Leukemia-Lymphoma Viruses; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; In Vitro; Intervening Sequences; Introns; LAV-HTLV-III; Leukemia Viruses, Human T-Cell; Lymphadenopathy-Associated Virus; MMTV; Mammals, Mice; Mammary Cancer Virus; Mammary Glands, Human; Mammary Tumor Virus, Mouse; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Modification; Molecular Interaction; Mouse Leukemia Viruses; Mouse Mammary Tumor Virus; Murine; Murine leukemia virus; Mus; Mutation; Names; Nuclear Export; Nucleus; ORFs; Open Reading Frames; Pathogenesis; Pathway interactions; Peptidases; Peptide Hydrolases; Phosphorylation; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Production; Proteases; Protein Coding Region; Protein Export; Protein Export Pathway; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein, rev; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteinases; Proteins; Proteolytic Enzymes; Proviruses; RNA; RNA Splicing; RNA Stability; RNA Transcriptase; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Viral; RNA-Dependent DNA Polymerase; RNA-Directed DNA Polymerase; Recruitment Activity; Reflex, Pharyngeal; Regulatory Protein; Reporter; Retroviridae; Retroviruses; Retroviruses, Human Endogenous; Reverse Transcriptase; Revertase; Ribonucleic Acid; Specificity; Splicing; Structural Protein; Superantigens; Time; Trans-Acting Factors; Trans-Activators; Transactivators; Transfection; Translating; Translatings; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Type B Virus; Unspecified Human T-Cell Leukemia Virus; Viral; Virus Replication; Virus-HIV; Virus-HTLV-Unspecified; Virus-Retrovirus; Yeasts; adapter protein; affinity purification; base; cell type; dUTP pyrophosphatase; dUTPase; deoxyuridine triphosphate nucleotidylhydrolase; deoxyuridinetriphosphatase; disease/disorder; experiment; experimental research; experimental study; gene product; genetic regulatory protein; genome mutation; in vivo; insight; language translation; mRNA; mRNA Export; mammary; mammary tumor virus; milk agent; mouse model; mutant; novel; pathway; recruit; regulatory gene product; research study; rev Protein; tissue culture; trans acting factor (genetic); vector; viral RNA; virus RNA; virus multiplication",Post-Transcriptional Regulation of MMTV,,116813,VIRA,Virology - A Study Section,,5,256806,
7760972,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA116933-04,,NCI:292600;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"ZHU, CHENGMING ;",2099443;,5R01CA116933,05/01/2007,02/29/2012,"ATM Signaling Pathway; ATM deficient; ATM function; ATM pathway; ATM signaling; Address; Adoptive Transfer; Affect; Antigen Receptors; Antigen T Cell Receptor, delta Chain; Apoptosis; Apoptosis Pathway; Articulation; Assay; Ataxia Telangiectasia; Ataxia Telangiectasia Syndrome; B blood cells; B lymphoma; B-Cell Development; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; Bioassay; Biologic Assays; Biological Assay; Blastocyst; Blastocyst structure; Blastosphere; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Breeding; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CHIP assay; CYTOGEN; Cancer Genes; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Culture System; Cell Culture Techniques; Cell Cycle; Cell Cycle Checkpoint; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Division Cycle; Cell Signaling; Cell surface; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromosomal Breaks; Chromosomal dislocation; Chromosomal translocation; Chromosome 14; Chromosome Break; Chromosomes, Human, Pair 14; Class Switching; Cleaved cell; Co-culture; Cocultivation; Coculture; Coculture Techniques; Code; Coding System; Complex; Containment; Cultured Cells; Cytogenetic; Cytogenetics; DNA; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Rearrangement; DNA Recombination; DNA Repair; DNA recombination (naturally occurring); DNA- PKcs protein; DNA-Activated Protein Kinase Catalytic Subunit; DNA-PK; DNA-activated protein kinase; DNA-dependent protein kinase; DNA-dependent protein serine-threonine kinase; DNAPK; DNPK1; Deoxyribonucleic Acid; Development; Diagnostic; Double Strand Break Repair; Double-Stranded DNA; EC 2.7; ES cell; Embryo, Preimplantation; Event; Exhibits; FLR; Failure (biologic function); Family; Fetal Liver; Gene Rearrangement; Genes; Genes, T-Cell Receptor; Genes, p53; Genetic Recombination; Genome; Genome Instability; Genome Stability; Genomic Instability; Genotype; Germinoblastoma; Goals; H2A Histone Family, Member X; H2A histone family, member X protein, human; H2A.X protein, human; H2A/X; H2AFX; H2AFX protein, human; H2AX; H2AX protein, human; HYRC1; Harvest; Histone H2A.X; Histone H2AX; Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1; ITX; IgK; Immune system; Immunoglobulin Class Switching; Immunoglobulin Isotype-Switch Recombination; Immunoglobulin Switch Recombination; Immunoglobulin V(D)J Rearrangement; Immunologically Directed Therapy; Immunotherapy; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Isotype Switching; Joints; Kinases; Lead; Length; Louis-Bar Syndrome; Lymphocyte; Lymphocytic; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lymphomagenesis; MHC Receptor; Maintenance; Maintenances; Major Histocompatibility Complex Receptor; Mammals, Mice; Mice; Modeling; Monitor; Mother Cells; Murine; Mus; Mutate; NHEJ; Non-Homologous End Joining; Nonhomologous DNA End Joining; Oncogenes; Oncogenesis; Oncogenic; P53; PRKDC; Pathway interactions; Pattern; Pb element; Peptide Signal Sequences; Phase; Phosphorylation; Phosphotransferases; Play; Population; Principal Investigator; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Reaction; Receptor Gene; Receptors, Antigen; Receptors, Antigen, T-Cell; Recombination; Recombination, Genetic; Regulation; Reporting; Research; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Reticulolymphosarcoma; Role; SCID protein; Sarcoma, Germinoblastic; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Stability, Genomic; Staging; Stem cells; Switch Recombination; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; Synapses; Synaptic; System; System, LOINC Axis 4; T-Cell Receptor; T-Cell Receptor Delta; T-Cell Receptor Genes; T-Cell Receptors delta-Chain; T-Cells; T-Lymphocyte; TCRD; TP53; TP53 gene; TRP53; TcR Genes; Testing; Therapeutic; Thymic Lymphoma; Thymus; Thymus Gland; Thymus Lymphoma; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Transforming Genes; Translocation, Genetic; Transphosphorylases; Tumor Antigens; Tumor Protein p53 Gene; Tumor-Associated Antigen; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Unscheduled DNA Synthesis; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; Wild Type Mouse; Work; XRCC7; XRCC7 protein; ataxia-telangiectasia; base; biological signal transduction; blastocyst; blastula; body system, allergic/immunologic; chromatin immunoprecipitation; chromosome dislocation; chromosome translocation; cleaved; design; designing; differentiated B cell; differentiated B lymphocyte; ds-DNA; embryonic stem cell; experiment; experimental research; experimental study; failure; gene product; heavy metal Pb; heavy metal lead; human H2AX protein; immune therapy; in vivo; insight; interest; lymph cell; member; mutant; nuclease; organ system, allergic/immunologic; p350; p460 protein; pathway; precursor cell; prevent; preventing; programs; protein complex; protein signal sequence; reconstitute; reconstitution; repair; repaired; research study; response; social role; stem cell of embryonic origin; thymocyte; thymus derived lymphocyte; tumor; tumor-specific antigen; tumorigenesis; tumorigenic; ubiquination; ubiquitin conjugation",Preventing Tumorigenesis in Developing Lymphocytes,,116933,CMIB,Cellular and Molecular Immunology - B Study Section,,4,292600,
7759152,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA117872-05,,NCI:207330;,2010,NATIONAL CANCER INSTITUTE,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"YE, KEQIANG ;",7115022;,5R01CA117872,03/08/2006,01/31/2011,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Accounting; Actins; Affinity; Ancient Neurilemmoma; Ancient Schwannoma; Anti-Oncogenes; Antibodies; Antioncogenes; Apoptosis; Apoptosis Pathway; Back; Binding; Binding (Molecular Function); Body Tissues; Brain; Cancers; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Process; Cell Proliferation; Cell Surface Glycoproteins; Cell physiology; CellLine; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Proliferation; Cytoskeletal System; Cytoskeleton; Degenerated Neurilemmoma; Degenerated Schwannoma; Development; Disease; Disorder; Dorsum; Drugs; EC 2.7; ERM protein; ETV5 protein; Emerogenes; Encephalon; Encephalons; Enhancers; Ets-related molecule PEA3-like protein; Family; Future; GTP Phosphohydrolases; GTPases; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Goals; Growth; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Human; Human, General; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intermediary Metabolism; Intracellular Membranes; Intracellular Second Messengers; Investigators; Kinases; Knowledge; Lipid Binding; Lipids; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane Glycoproteins; Membrane Proteins; Membrane-Associated Proteins; Merlin; Metabolic Processes; Metabolism; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Moesin-Ezrin-Radixin-Like Protein; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Motility; Motility, Cellular; NF2 Gene Product; Neoplasm Metastasis; Nervous System, Brain; Neurilemmoma; Neurilemoma; Neurinoma; Neurofibromatosis 2 Gene Product; Neurofibromatosis Type 2 Protein; Neurofibromin 2; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenic; PI-3 Kinase; PI-3K; PI3-Kinase; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; PtdIns; PtdIns 3-Kinase; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Research Personnel; Researchers; Role; Schwannoma; Schwannomerlin; Schwannomin; Schwannomin Protein; Second Messenger Systems; Second Messengers; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Subcellular Process; Surface Glycoproteins; Surface Proteins; Testing; Tissue Growth; Tissues; Transphosphorylases; Tumor Cell Migration; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; angiogenesis; base; cancer metastasis; cartilage link protein; cell motility; conformation; conformational state; cultured cell line; disease/disorder; drug/agent; experiment; experimental research; experimental study; feeding; gene product; guanosinetriphosphatase; in vivo; insight; intracellular skeleton; knock-down; link protein; malignancy; mutant; neoplasm/cancer; novel; oncosuppressor gene; ontogeny; programs; research study; second messenger; social role; tumor; tumor suppressor; tumorigenic",The Role of Merlin Phosphorylation on its Tumor Suppressive Activity,,117872,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,207330,
7756655,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA117895-04,,NCI:248978;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,PSYCHOLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"XU, XIAOCHUN ;",1868515;,5R01CA117895,04/03/2007,01/31/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-; 3,4-Benzopyrene; 3,4-Benzpyrene; 7,8-BaP-9,10-Diol Epoxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(a)pyrene; 9-cis-Retinoic Acid Receptor; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; ATP-protein phosphotransferase; ATRA; Abbreviations; Acids, Bile; Activator Protein-1; Adenocarcinoma; Adenocarcinoma of the Esophagus; Adenoma, Malignant; Air Pollution, Tobacco Smoke; All-trans retinoic acid; Anastomosis; Anastomosis - action; Anti-BaPDE; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Apoptosis; Apoptosis Pathway; Athymic Nude Mouse; BPDE; Benzo(10,11)chryseno(3,4-b)oxirene-7,8-diol, 7,8,8a,9a-tetrahydro-; Benzo(a)pyrene; Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide; Benzo(a)pyrene-7,8-diol 9,10-Epoxide; Bile Acids; Breast; CCND1 Protein; COX-2; COX-2 protein; COX2; COX2 enzyme; Cancer Causing Agents; Cancer Cell Growth; Cancer Induction; Cancer cell line; Cancer of the Esophagus; Cancers; Carcinogens; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Chemoprevention; Chemoprevention, Clinical; Chemopreventive; Chemopreventive Agent; Cholan-24-oic acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-; Clinical Chemoprevention; Combined Modality Therapy; Common Rat Strains; Complementary DNA; Curcumin; Cyclin D1; Cyclo-Oxygenase-2; Cyclooxygenase; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA, Complementary; DNA-Methyltransferases; Deoxycholic Acid; Desoxycholic Acid; Development; Diferuloylmethane; Dihydroxycholanoic Acid; Disease; Disorder; Dnmt; Drug Combinations; Drugs; EC 2.1.1.113; EGCG; EGCG cpd; EGFR; ERBB Protein; ERBB1; Effectiveness; Enhancer-Binding Protein AP1; Environmental Pollution, Tobacco Smoke; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epigallocatechin Gallate; Epigallocatechingallate; Epoxides; Epoxy Compounds; Esophageal; Esophageal Adenocarcinoma; Esophageal Cancer; Esophageal Reflux; Esophageal Tissue; Esophagus Cancer; Event; G1/S-Specific Cyclin D1; GERD; Gastro-oesophageal Reflux; Gastroesophageal Reflux; Gastroesophageal reflux disease; Gene Expression; Gene Targeting; Genes; Glycols; Green Tea Extract; Green Tea Polyphenols; HER1; Head and Neck; Head and neck structure; Health; Heterograft; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; Lung; Malignant; Malignant - descriptor; Malignant Cell; Malignant Esophageal Neoplasm; Malignant Esophageal Tumor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Esophagus; Malignant neoplasm of esophagus; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medication; Methylation; Mice, Athymic; Mice, Nude; Modeling; Modification Methylases; Molecular; Molecular Target; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; NSAIDs; Nature; Non-Steroidal Anti-Inflammatory Agents; Nonsteroidal Anti-Inflammatory Agents; Nonsteroidal Antiinflammatory Drug; Nude Mice; Oncogens; PCR; PGG/HS; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PHS-2; PRAD1 Protein; PTGS2; PTGS2 gene; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Polymerase Chain Reaction; Pre-Malignant; Premalignant; Prevention; Prevention of Esophageal Cancer; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Binding; Protein Kinase; Protein Methylation; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-1; RNA, Small Interfering; RXR; RXR Protein; Rat; Rattus; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Retinoic Acid; Retinoic Acid Receptor; Retinoic Acid Receptor RXR; Retinoid Receptor; Retinoid X Receptors; Risk Factors; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site-Specific DNA-methyltransferase; Small G-Proteins; Small GTPases; Small Interfering RNA; Squamous Cell Epithelioma; Squamous cell carcinoma; Surgical Models; Targetings, Gene; Tea catechin; Testing; Tobacco Smoke Pollution; Tobacco smoke; Trans Vitamin A Acid; Transcription Factor AP-1; Transforming Growth Factor alpha Receptor; Translating; Translatings; Transplantation, Heterologous; Tretinoin; Tretinoinum; Tumor Cell; Turmeric Yellow; Vitamin A Acid; Xenograft; Xenograft procedure; Xenotransplantation; all-trans-Retinoic Acid; all-trans-Vitamin A acid; anticarcinogenic; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; biomarker; c-bcl-1 Proteins; c-erbB-1; c-erbB-1 Protein; cDNA; cancer cell; cancer risk; carcinogenesis; cell growth; combination therapy; combined modality treatment; combined treatment; cyclin D; cyclo-oxygenase II; cyclooxygenase 2; disease/disorder; drug/agent; epigallo-catechin gallate; epigallocatechin; epigallocatechol; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; esophageal cancer prevention; experiment; experimental research; experimental study; gallocatechin; gallocatechol; gene product; glycogen synthase a kinase; hCOX-2; hydroxyalkyl protein kinase; in vivo; language translation; malignancy; multimodality therapy; neoplasm/cancer; neoplastic cell; new approaches; nonsteroidal anti-inflammatory drugs; novel; novel approaches; novel strategies; novel strategy; pathway; phosphorylase b kinase kinase; precancerous; preclinical evaluation; prevent; preventing; programs; prostaglandin H synthase-2; proto-oncogene protein c-erbB-1; pulmonary; receptor; receptor expression; research study; resistant; restoration; siRNA; trans-Retinoic Acid; tumor",Targeting RAR-beta2-led Gene Pathway in Prevention of Esophageal Cancer,,117895,CDP,Chemo/Dietary Prevention Study Section,,4,248978,
7764740,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA117907-05,,NCI:205444;,2010,NATIONAL CANCER INSTITUTE,,BOULDER,UNITED STATES,BIOCHEMISTRY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"ESPINOSA, JOAQUIN M;",8239940;,5R01CA117907,05/26/2006,01/31/2011,"Accounting; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Cycle Arrest; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Stress; Cellular Tumor Antigen P53; Cessation of life; ChIP (chromatin immunoprecipitation); Complex; DNA Damage; DNA Injury; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; Data; Death; Defect; Development; Drugs; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genotoxic Stress; Goals; Human; Human, General; Hypoxia; Hypoxic; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; MDM 2; MDM2; MDM2 gene; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Modification; Molecular; Mutation; Nature; Oncogene Activation; Oncogenic; Oncoprotein p53; Oxygen Deficiency; P53; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Pol II; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein TP53; Protein p53; Quelling; RNA; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; Recruitment Activity; Regulation; Research; Research Personnel; Researchers; Resistance; Ribonucleic Acid; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Stimulus; Stress; Stress Response Signaling; Stress, Genotoxic; Subcellular Process; TP53; TP53 gene; TRP53; Targetings, Gene; Technology; Testing; Therapeutic; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Up-Regulation; Work; anticancer therapy; base; biological signal transduction; cancer cell; cancer therapy; cell type; chromatin immunoprecipitation; combinatorial; drug/agent; genome mutation; histone modification; insight; interventional strategy; malignancy; neoplasm/cancer; neoplastic cell; p53 Antigen; p53 Tumor Suppressor; p53-Binding Protein Gene; pathway; prevent; preventing; programs; recruit; resistant; response; small molecule; social role; tool; transcription factor; tumor; tumor growth; tumor suppressor",Stress- and Promoter-Specific Mechanisms of Transcritpional Activation by p53,,117907,CAMP,Cancer Molecular Pathobiology Study Section,,5,205444,
7755811,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118089-04,,NCI:282880;,2010,NATIONAL CANCER INSTITUTE,,DETROIT,UNITED STATES,PATHOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"REDDY, KALADHAR B.;",1902904;,5R01CA118089,04/01/2007,01/31/2012,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; AKT; APO2L; Adverse effects; Akt protein; Anti-Estrogens; Antiestrogens; Apo-2L; Apoptosis; Apoptosis Pathway; Breast; Breast Cancer Treatment; Breast Neoplasms; Breast Tumors; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cancer Cause; Cancer Etiology; Cancer of Breast; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cessation of life; Clinical; Data; Death; Development; Disease; Disorder; Drugs; ERalpha; Estradiol Receptor alpha; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptor alpha; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Extracellular Signal-Regulated Kinase Gene; Future; Generalized Growth; Growth; Human; Human, General; In Vitro; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Knowledge; MAP Kinase Gene; MAPK; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Medication; Mitogen-Activated Protein Kinase Gene; Molecular; Molecular Target; PKB protein; PKC; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Play; Protein Kinase B; Protein Kinase C; Proto-Oncogene Proteins c-akt; RAC-PK protein; RNA, Small Interfering; Recurrence; Recurrent; Regulation; Relapse; Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small Interfering RNA; Staining method; Stainings; Stains; Stream; TAM; TL2; TNFSF10; TNFSF10 gene; TRAIL; Tamoxifen; Testing; Therapeutic Estrogen; Tissue Growth; Translating; Translatings; Treatment Side Effects; Tumor Cell; Woman; antiestrogen; antiestrogenic; base; biological signal transduction; c-akt protein; cultured cell line; disease/disorder; drug/agent; estrogen inhibitor; in vivo; inhibitor; inhibitor/antagonist; insight; interventional strategy; language translation; malignant breast neoplasm; mammary tumor; neoplastic cell; novel; ontogeny; overexpression; pathway; prevent; preventing; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; resistant; rottlerin; siRNA; side effect; social role; therapy adverse effect; treatment adverse effect; treatment strategy; tumor; tumor growth; tumor xenograft",Protein Kinase C Signaling and Breast Cancer,,118089,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,4,282880,
7759124,R01,CA,5,,02/01/2010,12/31/2010,,5R01CA118159-04,,NCI:315438;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073724262,US,PA,191112434,FOX CHASE CANCER CENTER,"ADAMS, GREGORY P;",2432239;,5R01CA118159,02/05/2007,12/31/2011,"ADCC; ATGN; Academia; Affect; Affinity; Antibodies; Antibodies, Tumor; Antibody -dependent cell cytotoxicity; Antibody Affinity; Antibody Degradation; Antibody-Dependent Cellular Cytotoxicity; Antigen Targeting; Antigenic Determinants; Antigens; Bears; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Bioavailability; Biodistribution; Biologic Availability; Biological Availability; Blood Circulation; Blood Vessels; Bloodstream; Caliber; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Cytoxicity, Antibody-Dependent; Cell Signaling; Cell surface; Cells; Circulation; Clinical; Combining Site; Complement-Dependent Cytotoxicity; Constant Region; Constant Region, Ig; DSS1; Data; Deleted In Split-Hand/Split-Foot 1 Region; Deleted in Split-Hand/Split-Foot 1 Region Gene; Development; Diameter; Diffuse; ECD; EGFR; ERBB Protein; ERBB1; ERBB2; ERBB2 gene; Engineering; Engineerings; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epitopes; Equilibrium; Future; Gamma Globulin, 7S; Generalized Growth; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Growth; HER -2; HER-2; HER1; HER2; HER2/neu; Human; Human EGF Receptor 2 Gene; Human, General; IgG; Immune system; Immunodeficient Mouse; Immunoglobulin Constant Region; Immunoglobulin G; Immunologic, Immunochemical; Immunologics; Industry; Intracellular Communication and Signaling; Killings; Lead; Learning; Length; Libraries; Ligand Binding; Ligands; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Microscopic; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Murine; Mus; Mutate; Names; Normal Tissue; Normal tissue morphology; Pb element; Penetration; Phage Display; Physiologic Availability; Play; Position; Positioning Attribute; Process; Property; Property, LOINC Axis 2; Public Health; Reactive Site; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Research; Role; Rosa; Rose; SEM1; SHFD1; SHFDG1; SHFM1; SHFM1 gene; SHSF1; Series; Signal Transduction; Signal Transduction Systems; Signaling; Solid Neoplasm; Solid Tumor; Stream; Structure; Surface; System; System, LOINC Axis 4; TKR1; Testing; Therapeutic; Time; Tissue Growth; Transforming Growth Factor alpha Receptor; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Treatment Efficacy; Tumor Antibodies; Tumor Antigens; Tumor Cell; Tumor-Associated Antigen; Ursidae; Ursidae Family; Variant; Variation; Work; antibody dependent cell mediated cytotoxicity; anticancer therapy; antigen antibody affinity; balance; balance function; base; bioavailability of drug; biological signal transduction; body system, allergic/immunologic; c-erbB-1; c-erbB-1 Protein; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer therapy; clinical relevance; clinically relevant; design; designing; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; heavy metal Pb; heavy metal lead; immunogen; in vivo; insight; language translation; malignancy; mouse model; mutant; neoplasm/cancer; neoplastic cell; ontogeny; organ system, allergic/immunologic; overexpression; proto-oncogene protein c-erbB-1; public health medicine (field); receptor; receptor internalization; social role; therapeutic efficacy; therapeutically effective; transgenic; tumor; tumor-specific antigen; vascular",Defining the Role of Affinity in Antibody-Based Tumor Targeting and Penetration,,118159,ZRG1,Special Emphasis Panel,,4,315438,
7767692,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA118165-04,,NCI:459777;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,PHARMACOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"KARIN, MICHAEL ;",1865946;,5R01CA118165,04/01/2007,02/29/2012,"Active Oxygen; Angiogenic Factor; Animal Model; Animal Models and Related Studies; Antioxidants; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Cancer Induction; Cancers; Carcinoma; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Death; Cell Signaling; Cells; Cessation of life; Chemicals; Chemopreventive; Chemopreventive Agent; DENA; Death; Development; Diethylnitrosamine; Drugs; EC 2.7; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Ethanamine, N-ethyl-N-nitroso-; Evaluation; Experimental Models; Experimental Models, Other; Exposure to; Factor, Angiogenesis; GFAC; Generalized Growth; Genes; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HCC; Hepatic Cancer; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocarcinogenesis; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Heterophil Granulocyte; Hypoxia; Hypoxic; INFLM; Immunoglobulin Enhancer-Binding Protein; Immunologic Receptors; Immunological Receptors; Individual; Inflammation; Inflammatory; Inflammatory Response; Intracellular Communication and Signaling; Kinases; Kupffer Cells; Laboratories; Lead; Liver; Liver Carcinogenesis; Liver Cells; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Mice; Marrow Neutrophil; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Models, Experimental; Molecular Genetic; Molecular Genetics; Murine; Mus; Myeloid Cells; N,N-diethylnitrosamine; N-Nitrosodiethylamine; N-diethylnitrosamine; NDEA; NF-kB; NF-kappa B; NF-kappaB; NFKB; Necrosis; Necrotic; Neoplasm Metastasis; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nitrosodiethylamine; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nutrient; O element; O2 element; Oxygen; Oxygen Deficiency; Oxygen Radicals; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Pre-Malignant; Premalignant; Primary carcinoma of the liver cells; Pro-Oxidants; Production; Radiation; Reactive Oxygen Species; Receptors, Immunologic; Relative; Relative (related person); Role; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Solid Neoplasm; Solid Tumor; Staging; Starvation; Stellate Sinusoidal Macrophage; Testing; Therapeutic; Tissue Growth; Transcription Factor NF-kB; Transphosphorylases; Tumor Cell Migration; Tumor Promotion; Tumor Tissue; Vascular blood supply; Vascularization; Virus; Viruses, General; Work; angiogenesis; anti-oxidant; anticarcinogenic; base; biological signal transduction; blood supply; body system, hepatic; cancer cell; cancer metastasis; cancer progression; carcinogenesis; carcinogenesis in the liver; cytokine; drug/agent; epithelial carcinoma; exhaust; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hepatocellular carcinogenesis; immune receptor; kappa B Enhancer Binding Protein; liver cancer; liver cancer pathogenesis; liver macrophage; macrophage; malignancy; malignant liver tumor; model organism; mouse model; necrocytosis; neoplasm blood supply; neoplasm progression; neoplasm vascular supply; neoplasm/cancer; neoplastic progression; neutrophil; nuclear factor kappa beta; ontogeny; organ system, hepatic; precancerous; ray (radiation); research study; response; social role; transcription factor; tumor; tumor blood supply; tumor growth; tumor progression; tumor vascular supply; vascular supply",Role of inflammation in tumor promotion and progression,,118165,TPM,Tumor Progression and Metastasis Study Section,,4,459777,
7760889,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118316-04,,NCI:409394;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"TENEN, DANIEL G;",6416084;,5R01CA118316,04/12/2007,01/31/2012,"AML - Acute Myeloid Leukemia; Acute leukemia; Adult AGL; Adult AML; Adult ANLL; Adult Acute Granulocytic Leukemia; Adult Acute Myeloblastic Leukemia; Adult Acute Myelocytic Leukemia; Adult Acute Myelogenous Leukemia; Adult Acute Myeloid Leukemia; Adult Acute Non-Lymphoblastic Leukemia; Adult Acute Non-Lymphocytic Leukemia; Adult Acute NonLymphoblastic Leukemia; Adult Acute NonLymphocytic Leukemia; Applications Grants; Blast Cell; Blasts; Blood (Leukemia); Blood Cells; C-EBP alpha; C-EBPalpha; C/EBP-alpha; CCAAT-Enhancer-Binding Protein-alpha; CEBP; CEBPA; CEBPA gene; Cancers; Cell Differentiation; Cell Differentiation process; Characteristics; Classification; Data; Development; Diagnostic; E2A; E2A Immunoglobulin Enhancer Binding Factor E12; E2A Immunoglobulin Enhancer Binding Factor E47; FLR; Failure (biologic function); Ferrata cell; Future; Gene Expression; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant Proposals; Grants, Applications; Hematohistioblast; Hematopoietic; Hemocytoblast; Hemohistioblast; Human; Human, General; ITF1; Immunoglobulin Transcription Factor 1; Investigators; Kappa-E2-Binding Factor; Knowledge; LEUKCL; Laboratories; Lead; Leukemia, Granulocytic; Leukemia, Myelocytic, Acute; Leukemias, General; Leukemic Cell; Limulus factor C; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Molecular; Mutation; Myeloblastic Leukemia, Acute; Myelocytic Leukemia; Myelogenous; Myelogenous Leukemia; Myelogenous Leukemia, Acute; Myeloid; Myeloid Cells; Myeloid Leukemia; Myelopoiesis; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Pathogenesis; Pathway interactions; Patients; Pattern; Pb element; Peripheral Blood Cell; Phenotype; Play; Process; Programs (PT); Programs [Publication Type]; Proteins; Public Health; Research; Research Personnel; Researchers; Role; Systematics; TCF3; Targetings, Gene; Testing; Therapeutic Intervention; Transcription Factor 3; Transcription Factor E2-Alpha; Translating; Translatings; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; factor C; failure; gene product; genome mutation; heavy metal Pb; heavy metal lead; horseshoe crab factor C; human disease; in vivo; intervention therapy; language translation; leukemia; malignancy; mutant; myeloid granulocytic leukemia; myelosis; neoplasm/cancer; novel; pathway; prognostic; programs; public health medicine (field); social role; tool; transcription factor; treatment strategy",Distinct acute myeloid leukemia subclasses with CEBPA mutations,,118316,CG,Cancer Genetics Study Section,,4,409394,
7758836,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118332-04,,NCI:478168;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,PEDIATRICS,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"COMPAS, BRUCE E;",1964982;,5R01CA118332,04/01/2007,01/31/2012,"0-11 years old; Active Follow-up; Address; African American; Afro American; Afroamerican; Age; American; Anxiety; Black Populations; Black or African American; Cancer Prognosis; Cancers; Caring; Cessation of life; Characteristics; Child; Child Youth; Childhood Cancers; Children (0-21); Cognitive; Communication; Complex; Conflict; Conflict (Psychology); Death; Depression; Diagnosis; Disease; Disorder; Distress; Education; Educational aspects; Environment; Equilibrium; Evidence based practice guidelines; Family; Fathers; Fear; Female; Forecast of outcome; Fright; Gender; Goals; Guidelines; HOSP; Health Care Professional; Health Care Providers; Health Personnel; Health Professional; Health profession; Healthcare Providers; Healthcare professional; Healthcare worker; History; Home; Home environment; Hospitals; Hospitals, Pediatric; Human, Child; Investigators; Malignant Childhood Neoplasm; Malignant Childhood Tumor; Malignant Neoplasms; Malignant Pediatric Neoplasm; Malignant Pediatric Tumor; Malignant Tumor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mental Depression; Methods; Mothers; NCI; NCI Organization; National Cancer Institute; Nature; Newly Diagnosed; Ohio; Outcome; Palliative Care; Palliative Treatment; Parents; Patients; Pediatric Hospitals; Pediatric Oncology; Probability; Process; Prognosis; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Questionnaires; Recording of previous events; Recruitment Activity; Recurrence; Recurrent; Relapse; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Site; Stress; Symptoms; Therapy, Palliative; Thinking; Thinking, function; Time; United States; Universities; balance; balance function; black American; cancer diagnosis; care giving; caregiving; children; cohesion; comfort care; coping; disease/disorder; emotional distress; evidence based guidelines; evidence based recommendations; feeling distress; feeling upset; follow-up; health care personnel; health care worker; health provider; healthcare personnel; male; malignancy; medical personnel; neoplasm/cancer; outcome forecast; parent-child communication; parental role; pediatric cancer; pediatric neoplasm/cancer; programs; psychological distress; public health medicine (field); recruit; role of parent; social role; syntactic; syntax; treatment provider; youngster",Parent-Child Communication About Cancer,,118332,ZRG1,Special Emphasis Panel,,4,478168,
7758384,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118357-05,,NCI:258530;,2010,NATIONAL CANCER INSTITUTE,,ALBUQUERQUE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"OSLEY, MARY ANN;",1896537;,5R01CA118357,03/01/2006,01/31/2011,"Assay; Bioassay; Biologic Assays; Biological Assay; CHIP assay; Candidate Disease Gene; Candidate Gene; ChIP (chromatin immunoprecipitation); Chemicals; Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Recombination; DNA Repair; DNA Replication; DNA Sequence Rearrangement; DNA Synthesis; DNA biosynthesis; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; DNA recombination (naturally occurring); Deoxyribonucleic Acid; Distal; Double Strand Break Repair; Electromagnetic Radiation, Ionizing; Elements; Enhancers; Gene Conversion; Gene Transcription; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic Transcription; Genetic defect; Genome; Genome Stability; Histone H2A; Histone H3; Investigators; Ionizing radiation; Kinetic; Kinetics; L-Lysine; Lesion; Lysine; Mating Types; Mediating; Methylation; Modification; Monitor; Mutation; NHEJ; NURF; Non-Homologous End Joining; Nonhomologous DNA End Joining; Nucleosome Remodeling Factor; Nucleosomes; Outcome; Pathway interactions; Peptide Domain; Phosphorylation; Play; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Domains; Protein Methylation; Protein Phosphorylation; Proteins; RNA Expression; Radiation; Radiation-Ionizing Total; Rearrangement; Recombination; Recombination, Genetic; Recruitment Activity; Regulation; Research Design; Research Personnel; Researchers; Resistance; Risk; Role; S cerevisiae; Saccharomyces cerevisiae; Series; Site; Stability, Genomic; Staging; Study Type; System; System, LOINC Axis 4; Tertiary Protein Structure; Testing; Transcription; Transcription, Genetic; Tumor Suppression; Tumor Suppression, Molecular; Unscheduled DNA Synthesis; Yeast, Baker's; Yeast, Brewer's; Yeasts; cancer radiation therapy; chemotherapy; chromatin immunoprecipitation; chromatin modification; chromatin protein; chromatin remodeling; gene product; genome mutation; histone modification; homologous recombination; man; man's; mutant; novel; pathway; programs; ray (radiation); recruit; repair; repaired; resistant; response; social role; study design; tumor",Chromatin Regulation of Double-Strand Break Repair,,118357,RTB,Radiation Therapeutics and Biology Study Section,,5,258530,
7769907,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118405-04,,NCI:286900;,2010,NATIONAL CANCER INSTITUTE,,GALVESTON,UNITED STATES,BIOCHEMISTRY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"SASTRY, SARITA KANDULA;",8241862;,5R01CA118405,05/01/2007,01/31/2012,"ATP[{..}]protein-tyrosine O-phosphotransferase; Adherens Junction; Adhering Junction; Adhesive Junction; Affect; Anchoring Junction; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Cadherins; Cancer Center; Cancer of the Gastrointestinal Tract; Candidate Disease Gene; Candidate Gene; Carcinoma Cell; Cell Communication and Signaling; Cell Junctions; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Cell Adhesion; Cells; Cellular Migration; Cellular biology; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Contact Inhibition; Cytosolic Protein Tyrosine Phosphastase; Doctor of Philosophy; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Ensure; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Fibroblasts; Foundations; Future; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GTP GDP exchange factor; Gastrointestinal Cancer; Genes; Goals; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; HEK3; Intercellular Junctions; Intracellular Communication and Signaling; Investigators; L-Tyrosine; Lead; Ligand Binding Protein; Liver Cell Adhesion Molecules; Malignant Cell; Malignant Epithelial Cell; Malignant Gastrointestinal Neoplasm; Malignant neoplasm of gastrointestinal tract; Medical; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular Interaction; Motility; Motility, Cellular; Mutate; Neoplasm Metastasis; PTK; PTP-PEST; PTPG1; PTPN12; PTPN12 gene; PTPase; Pb element; Ph.D.; PhD; Phenotype; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Programs (PT); Programs [Publication Type]; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Phosphatase; Proteins; Regulation; Research; Research Personnel; Researchers; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Site; TYR; Testing; Texas; Tumor Cell Migration; Tumor Suppressor Proteins; Tyrosine; Tyrosine Kinase; Tyrosine Phosphatase; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosyl Phosphoprotein Phosphatase; Tyrosylprotein Kinase; Universities; VAV2; VAV2 gene; Work; anticancer research; base; biological signal transduction; biomarker; cancer cell; cancer metastasis; cancer progression; cancer research; catenin p120(ctn) protein; catenin p120ctn protein; cell biology; cell motility; effective therapy; exchange factor; functional loss; gene product; heavy metal Pb; heavy metal lead; hydroxyaryl protein kinase; liver cell adhesion molecule; neoplasm progression; neoplastic progression; p120(ctn); p120ctn; para-Tyrosine; programs; protein tyrosine phosphate phosphohydrolase; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; success; tool; tumor progression; tumor suppressor; tyrosyl protein kinase",Regulation and Function of PTP-PEST in colon carcinoma,,118405,TPM,Tumor Progression and Metastasis Study Section,,4,286900,
7760070,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118495-05,,NCI:291276;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PHARMACOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"PHILIPS, MARK REID;",1892888;,5R01CA118495,03/01/2006,01/31/2011,"5-prenylcysteine methyltransferase; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Attention; Biochemical; Biochemistry; Biological; Biological Function; Biological Process; Biology; Body Tissues; Breast Cancer Model; Breast Carcinoma; Breeding; C-terminal; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer-Promoting Gene; Cancers; Catalysis; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Membrane; Chemicals; Chemistry, Biological; Chemotherapeutic Agents, Neoplastic Disease; Co-Immunoprecipitations; Cytosol; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA-Methyltransferases; Dnmt; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.1.1; EC 2.1.1.113; Enzymatic Biochemistry; Enzymes; Enzymology; FPP synthetase; FTI; Face; Farnesyl Transferase Inhibitor; Farnesyl diphosphate synthetase; Farnesyltransferase Inhibitors; Fibroblasts; GTP Phosphohydrolases; GTPases; Gene Products, ras; Generalized Growth; Genes; Geranyltranstransferase; Growth; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; H-ras; H-ras Gene; H-ras Oncogene; HRAS; HRAS gene; HRAS1; Harvey Rat Sarcoma Viral Oncogene Homolog; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; Isoforms; Laboratories; Libraries; Maintenance; Maintenances; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Maps; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Methylation; Methyltransferase; Mice; Modeling; Modification Methylases; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; N-terminal; NH2-terminal; Oncogenes; Oncogenesis; Ortholog; Orthologous Gene; PCC methyltransferase; PPMTase; Pathway interactions; Phylogenetic Analysis; Phylogenetics; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Cleavage; Protein Family; Protein Farnesyltransferase Inhibitors; Protein Isoforms; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteolysis; Proteomics; Publications; RAS Gene; RASH1; RNA, Small Interfering; Ras Signaling Pathway; Reaction; Regulation; Relative; Relative (related person); Research Design; Research Personnel; Researchers; Resistance; Role; SEQ-AN; Scientific Publication; Sequence Analyses; Sequence Analysis; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site-Specific DNA-methyltransferase; Small G-Proteins; Small GTPases; Small Interfering RNA; Structure; Study Type; Surface Proteins; Testing; Time; Tissue Growth; Tissues; Transforming Genes; Transgenic Organisms; Tumor Cell; Tumor-Specific Treatment Agents; Yeasts; anticancer agent; anticancer drug; anticancer therapy; biological signal transduction; cancer therapy; clinical efficacy; cross-link; crosslink; drug discovery; experience; experiment; experimental research; experimental study; facial; farnesyl cysteine C-terminal methyltransferase; farnesyl cysteine carboxyl methyltransferase; farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase; fascinate; gene product; genetically modified cells; geranyltransferase; guanosinetriphosphatase; in vivo; inhibitor; inhibitor/antagonist; interest; isoprenylated protein methyltransferase; isoprenylcysteine carboxyl methyltransferase; malignancy; mammary cancer model; mammary tumor model; member; membrane structure; methylase; mutant; neoplasm/cancer; neoplastic cell; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; pathway; polypeptide; preclinical study; prenylated protein carboxyl methyltransferase; prenylation; prenylcysteine carboxyl methyltransferase; prenylcysteine carboxymethyltransferase; protein C-terminal prenylcysteine methyltransferase; protein-S-isoprenylcysteine O-methyltransferase; protein-cysteine-carboxyl methyltransferase; rab G-Proteins; rab GTP-Binding Proteins; rab GTPases; ras Proteins; recombinase; research study; resistant; rho; siRNA; social role; study design; success; trafficking; transgenic; transmethylase; tumor; tumorigenesis; v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog",Structure/Function Analysis of Icmt,,118495,ZRG1,Special Emphasis Panel,,5,291276,
7756652,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118561-05,,NCI:247021;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GU, WEI ;",6190502;,5R01CA118561,03/24/2006,01/31/2011,"ARF; ARF tumor suppressor, mouse; Age; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Biochemical; CDK4I; CDKN2; CDKN2A; CDKN2A gene; CMM2; Cdkn2a(p19ARF); Cell Aging; Cell Cycle Arrest; Cell Death, Programmed; Cell Senescence; Cells; Cellular Aging; Cellular Expansion; Cellular Growth; Complex; Cyclin-Dependent Kinase Inhibitor 2A Gene; Defect; GeneHomolog; Generalized Growth; Genes, CDKN2; Genes, p16; Genes, p16INK4A; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Homolog; Homologous Gene; Homologue; Human; Human, General; INK4; INK4A; Lymphocytes, Null; MLM; MTS1; MTS1 Genes; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Molecular Interaction; Murine; Mus; Mutation; Neoplasm Metastasis; Nuclear; Null Cells; Null Lymphocytes; Oncogene Activation; Oncogenesis; P53; Pathway interactions; Phosphorylation; Photometry/Spectrum Analysis, Mass; Process; Protein Phosphorylation; Regulation; Role; Secondary Neoplasm; Secondary Tumor; Senescence, Cellular; Senescence, Replicative; Skin Cancer, Non-Melanoma; Skin Carcinoma; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stress; TP16; TP53; TP53 gene; TRP53; TSG9A; Testing; Tissue Growth; Transcript; Tumor Cell; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; biological adaptation to stress; cancer metastasis; cell growth; genome mutation; in vivo; insight; neoplastic cell; nonmelanoma skin cancer; novel; ontogeny; p14ARF; p16INK4 Genes; p16INK4a; p19(ARF); p19(ARF) protein; p19(ARF) protein, mouse; p19ARF; pathway; polypeptide; reaction; crisis; response; social role; stress response; stress; reaction; tumor; tumor suppressor; tumorigenesis; ubiquitin ligase",The role of ARF-BP1 in tumorigenesis,,118561,ZRG1,Special Emphasis Panel,,5,247021,
7851420,R01,CA,5,,02/01/2010,01/31/2011,PA-05-029,5R01CA118663-04,,NCI:497611;,2010,NATIONAL CANCER INSTITUTE,,TEMPE,UNITED STATES,NONE,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"LARKEY, LINDA K;",1876535;,5R01CA118663,02/01/2007,01/31/2012,"Address; Alcohols; Arm; Attitude; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Characteristics; Chemical Class, Alcohol; Colon or Rectum; Colorectal; Colorectal Cancer; Consumption; Development; Dimensions; Education; Educational aspects; Elements; Endoscopy; Exposure to; Health; Health Educators; Health behavior; Hispanic Populations; Hispanics; Hispanics or Latinos; Incidence; Intervention; Intervention Strategies; Latino; Latino Population; Lead; Learning; Low income; Maintenance; Maintenances; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Modeling; Mortality; Mortality Vital Statistics; Negotiating; Negotiation; Obesity; Outcome; Participant; Pb element; Physical activity; Planning Theory; Population; Predictive Factor; Prevention; Prevention of Colorectal Cancer; Primary Prevention; Programs (PT); Programs [Publication Type]; Randomized Controlled Trials; Red Meat Consumption; Relative; Relative (related person); Risk Behaviors; Risky Behavior; Role; Screening procedure; Spanish Origin; TXT; Testing; Text; Theory, Planning; Tobacco Consumption; Tobacco use; Transportation; Underserved Population; Upper arm; Vegetables; Work; adiposity; at risk behavior; base; behavior change; behavioral control; calcium intake; cancer prevention; cancer risk; colorectal cancer prevention; community intervention; community setting; comparative; corpulence; corpulency; corpulentia; design; designing; dietary vegetable; experience; group intervention; heavy metal Pb; heavy metal lead; hispanic community; improved; instrument; intervention effect; interventional strategy; novel; obese; obese people; obese person; obese population; post intervention; programs; randomized controlled study; red meat consumption; rehearsal; response; screening; screenings; social role; theories; under served population; underserved people",Storytelling for Colorectal Health among Latinos,,118663,CLHP,Community-Level Health Promotion Study Section,,4,497611,
7753590,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA118740-03,,NCI:323078;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"RUI, HALLGEIR ;",1903422;,5R01CA118740,04/07/2008,01/31/2013,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; ATP[{..}]protein-tyrosine O-phosphotransferase; Adjuvant; Adriamycine; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibodies; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Apoptotic; Arts; Asotax; Autocrine Systems; Biochemical; Biology; Blood Serum; Body Tissues; Breast; Breast Cancer Cell; Breast Cancer Model; Bristaxol; Cancer Drug; Cancer Patient; Cancer Treatment; Cancer cell line; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cessation of life; Chemotherapeutic Agents, Neoplastic Disease; Chemotherapy-Hormones/Steroids; Clinic; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Complement; Complement Proteins; DOX; Data; Death; Development; Differentiation and Growth; Doxorubicin; Doxorubicina; Drugs; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endocrine; Endocrine Gland Secretion; Engineering; Engineerings; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial; Epithelial Cells; Evaluation; Expenditure; Experimental Models; Experimental Models, Other; Generalized Growth; Goals; Government; Growth; HEK3; Histology; Home-Bound Persons; Homebound Persons; Hormonal; Hormones; House-Bound Persons; Human; Human Breast Cancer Cell; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; In Situ; In Vitro; Institution; Intracellular Communication and Signaling; LTH; Laboratories; Lactogenic Hormone, Pituitary; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Glands, Human; Mammary gland; Mammotropic Hormone, Pituitary; Mammotropin; Man (Taxonomy); Man, Modern; Medical; Medication; Medicine; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Modeling; Models, Experimental; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neoplasm Metastasis; PRL; PRL (Prolactin); PTK; Paclitaxel; Paclitaxel (Taxol); Pain; Painful; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphorylation; Physiologic; Physiological; Pituitary Hormones; Post-Menopause; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-menopausal Period; Postmenopausal Period; Postmenopause; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Praxel; Pre-Clinical Model; Pre-Menopause; Pre-menopausal Period; Preclinical Models; Preclinical Testing; Premenopausal; Premenopausal Period; Premenopause; Primary Neoplasm; Primary Tumor; Prolactin; Prolactin Receptor; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Receptor Signaling; Receptors, PRL; Research; Research Resources; Resources; Role; Science of Medicine; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Shut-In; Shut-Ins; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Therapeutic Agents; Therapeutic Hormone; Tissue Arrays; Tissue Chip; Tissue Growth; Tissue Microarray; Tissues; Transplantation; Tumor Cell Line; Tumor Cell Migration; Tumor-Specific Treatment Agents; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; United States National Institutes of Health; Woman; Work; anticancer agent; anticancer drug; anticancer therapy; antitumor agent; antitumor drug; autocrine; base; biological signal transduction; breast cancer diagnosis; cancer cell; cancer metastasis; cancer therapy; clinical efficacy; clinical investigation; cultured cell line; density; drug candidate; drug detection; drug sensitivity; drug testing; drug/agent; efficacy testing; expectation; gene product; hydroxyaryl protein kinase; improved; in vivo; inhibitor; inhibitor/antagonist; insight; knock-down; luteotropic hormone; luteotropin; malignancy; malignant breast neoplasm; mammary; mammary cancer model; mammary tumor model; mouse model; mutant; neoplasm/cancer; novel; ontogeny; pathway; post-menopausal; postmenopausal; pre-clinical; pre-menopausal; preclinical; prevent; preventing; receptor; response; social role; therapeutic target; transplant; trial regimen; trial treatment; tumor; tyrosyl protein kinase",Experimental Modeling of Human Breast Cancer in Mice,,118740,TCB,Tumor Cell Biology Study Section,,3,323078,
7772264,R01,CA,5,,03/01/2010,02/28/2011,,5R01CA118880-04,,NCI:235181;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"BRICKNER, ANTHONY G;",3076111;,5R01CA118880,05/10/2007,02/28/2012,"Algorithms; Allele Frequency; Allogenic; Amino Acids; Antigenic Determinants; Autologous Dendritic Cells; Avidity; Binding Determinants; Cell surface; Cells; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Detection; Economics; Epitopes; Exhibits; Frequencies (time pattern); Frequency; GVHD; GVL; Gene Frequency; Gene Products, RNA; Genes; Genetic Polymorphism; Genotype; Goals; Graft vs Leukemia Effect; Graft-Versus-Host Disease; Graft-Versus-Tumor Induction; Graft-vs-Host Disease; Graft-vs-Leukemia Response; HLA Class I Histocompatibility Antigen, A-2 Alpha Chain; HLA-A; HLA-A Class I Antigen 2; HLA-A Histocompatibility Type Antigen 2; HLA-A2; HLA-A2 Antigen; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Cancer; Homologous Wasting Disease; Human; Human, General; ITX; Immunocompetent; Immunologically Directed Therapy; Immunotherapy; In Vitro; Investigators; MHC binding peptide; Major Histocompatibility Complex, Class I, A2 Antigen; Malignant; Malignant - descriptor; Malignant Cell; Malignant Hematologic Neoplasm; Man (Taxonomy); Man, Modern; Mediating; Methods; Minor Histocompatibility Antigens; Minor Histocompatibility Peptides; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Patients; Peptides; Physiologic pulse; Polymorphism (Genetics); Polymorphism, Genetic; Progenitor Cell Transplantation; Proteins; Pulse; RNA; RNA, Non-Polyadenylated; Research Personnel; Researchers; Ribonucleic Acid; Runt Disease; Screening procedure; Stem Cell Transplantation; Stem cell transplant; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; allelic frequency; aminoacid; base; cancer cell; clinical applicability; clinical application; clinical data repository; clinical data warehouse; data repository; experiment; experimental research; experimental study; gene product; graft versus host disease induction; graft-versus-tumor; immune therapy; immunogenicity; innovate; innovation; innovative; patient population; polymorphism; relational database; research study; response; screening; screenings; thymus derived lymphocyte",Hematopoietic Lineage-restricted Minor Histocompatibility Antigens as GVL Targets,,118880,ZRG1,Special Emphasis Panel,,4,235181,
7760183,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA118887-05,,NCI:235778;,2010,NATIONAL CANCER INSTITUTE,,DAVIS,UNITED STATES,UROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"GAO, ALLEN C;",6619657;,5R01CA118887,03/06/2006,01/31/2011,"4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide; 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide; 4-Cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline; Adenocarcinoma; Adenoma, Malignant; Androgen Antagonists; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Anti-Androgen; Anti-Androgen Agents; Anti-androgen Therapy; Anti-androgen Treatment; Antiandrogen Agents; Antiandrogen Therapy; Antiandrogen Treatment; Antiandrogens; Apoptotic; Assay; Astra brand of bicalutamide; AstraZeneca brand of bicalutamide; Bicalutamide; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cancer Cell Growth; Cancer of Prostate; Casodex; Cell Communication and Signaling; Cell Cycle Progression; Cell Death; Cell Signaling; Cellular Expansion; Cellular Growth; ChIP (chromatin immunoprecipitation); Chemopreventive; Chemopreventive Agent; Cosudex; DU145; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 3.4.21.34; Fletcher Factor; Gene Expression; Gene Targeting; Gene Transcription; Generalized Growth; Genetic Transcription; Genital System, Male, Prostate; Goals; Growth; Human; Human Prostate; Human Prostate Gland; Human, General; In Vitro; Incidence; Inhibition of Apoptosis; Intracellular Communication and Signaling; Investigators; KLK3; Kallikrein 3; LNCaP; Ligand Binding; Malignant Cell; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Modeling; Molecular; Molecular Interaction; N-[4-Cyano-3-(trifluoromethyl)phenyl]3-3[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide; Nuclear Translocation; P-30 Antigen; PC3 cell line; Plasma Kallikrein Precursor; Plasma Prekallikrein; Play; Post-Translational Regulation; Posttranslational Regulation; Prevention; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostatic Cancer; Prostatic Gland; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; RNA Expression; RNA, Messenger; RNA, Small Interfering; Receptor Protein; Receptor Signaling; Relapse; Research Personnel; Researchers; Role; Se element; Selenium; Semenogelase; Seminin; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Stability, mRNA; Targetings, Gene; Testing; Therapeutic Androgen; Tissue Growth; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Validation; Xenograft Model; Zeneca brand of bicalutamide; androgen independent prostate cancer; androgen inhibitor; anticarcinogenic; base; biological signal transduction; cancer cell; cancer chemoprevention; cell growth; chemoprevention of cancer; chromatin immunoprecipitation; common treatment; deprivation; gamma-Seminoprotein; genetic promoter element; hK3 Kallikrein; immunocytochemistry; improved; in vivo; kininogenin; knock-down; mRNA; mRNA Stability; men; men's; mouse model; necrocytosis; novel; ontogeny; overexpression; prevent; preventing; programs; prostate cancer cell line; prostate carcinogenesis; protein degradation; receptor; receptor binding; receptor expression; siRNA; social role; transcription factor",Selenium regulates androgen receptor signaling in prostate cancer,,118887,ZRG1,Special Emphasis Panel,,5,235778,
7755819,R01,CA,5,,02/01/2010,01/31/2011,PAR-02-143,5R01CA118919-05,,NCI:307485;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LIU, BIN ;",7041694;,5R01CA118919,03/07/2006,01/31/2011,"ATGN; Address; Affinity; Androgenic Agents; Androgenic Compounds; Androgens; Animal Model; Animal Models and Related Studies; Antibodies; Antigen Targeting; Antigenic Determinants; Antigens; Assay; Bacteriophages; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Cancer of Prostate; Carbohydrates; Cell Communication and Signaling; Cell Line, Tumor; Cell Signaling; Cell Surface Antigens; Cell surface; Cells; Chemicals; Chemistry; Chimp; Chimpanzee; Complementary DNA; Cultured Tumor Cells; DNA, Complementary; Development; Diagnostic; Directed Molecular Evolution; Environment; Epitopes; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; Freezing; Gene Expression; Generalized Growth; Generations; Genes; Genomics; Goals; Growth; Health; Human; Human, General; Immune Surveillance; Immunoglobulin V; Immunoglobulin Variable Region; Immunologic Surveillance; Immunological Surveillance; In Situ; Individual; Intracellular Communication and Signaling; Investigators; Knowledge; Libraries; Life; Malignant Cell; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Moab, Clinical Treatment; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monoclonal Antibodies; NIH Program Announcements; Neoplasm Metastasis; Neoplastic Cells, Cultured; Noise; Organ; Output; Pan; Pan Genus; Pan Species; Pathogenesis; Phage Display; Phages; Photometry/Spectrum Analysis, Mass; Physiology; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Neoplasm; Primary Tumor; Program Announcement; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Relative; Relative (related person); Research; Research Personnel; Researchers; Sampling; Science of Chemistry; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Slide; Sorting - Cell Movement; Sortings, Fluorescence-Activated Cell; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Surface; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Surveillances, Immunologic; Surveillances, Immunological; System; System, LOINC Axis 4; TM-MKR; Techniques; Technology; Therapeutic; Therapeutic Androgen; Tissue Growth; Tissues; Tumor Antigens; Tumor Cell; Tumor Cell Line; Tumor Cell Migration; Tumor Cells, Cultured; Tumor Markers; Tumor-Associated Antigen; Variable Region; Variable Region, Ig; Variant; Variation; Work; Yeasts; aminoacid sequence of peptide; aminoacid sequence of protein; bacterial virus; base; biological signal transduction; biomarker; cDNA; cDNA Library; cancer cell; cancer metastasis; cancer type; cell type; clinical relevance; clinical significance; clinically relevant; clinically significant; combinatorial; conformation; conformational state; design; designing; drug development; effective therapy; experiment; experimental research; experimental study; gene product; immunogen; improved; laser capture microdissection; mRNA Expression; model organism; neoplastic; neoplastic cell; new diagnostics; next generation diagnostics; novel; novel diagnostics; ontogeny; peptide sequence; prognostic; programs; protein aminoacid sequence; receptor mediated endocytosis; research study; selective expression; selectively expressed; sorting; tool; tumor; tumor-specific antigen",Mapping a clinically significant internalizing tumor epitope space.,,118919,ZRG1,Special Emphasis Panel,,5,307485,
7761284,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA119066-05,,NCI:303525;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"LOOK, A THOMAS;",2147791;,5R01CA119066,03/01/2006,01/31/2011,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Accounting; Adexone; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anemul mono; Animal Model; Animal Models and Related Studies; Antibodies; Antimicotico; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Aquapred; Auxiloson; Azona; B blood cells; B lymphoma; B-Cell CLL/Lymphoma 2 Gene; B-Cell CLL/lymphoma 2; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; BCL-2 Protein; BCL2; BCL2 gene; BCL2 protein; Baycuten; Baycuten N; Body Tissues; Brachydanio rerio; Brill-Symmers Disease; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C elegans; C.elegans; Caenorhabditis elegans; Cancer Genes; Cancer Induction; Cancer Radiotherapy; Cancer Treatment; Cancer-Promoting Gene; Cancers; Cell Death; Cell Death, Programmed; Cell Transplantation; Cells; Chimp; Chimpanzee; Chromosomal dislocation; Chromosomal translocation; Chromosome Mapping; Cloning; Collection; Complement; Complement Proteins; Corson; Cortidexason; Cortisumman; Cytofluorometry, Flow; DNA Damage; DNA Injury; Danio rerio; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drugs; Effectiveness; Family; Family member; Fishes; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Fluorescence Microscopy; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Follicle Center Lymphoma; Follicular Lymphoma; Follicular Non-Hodgkin's Lymphoma; Fortecortin; Future; GWAS; Gammacorten; Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; GeneHomolog; Generations; Genes; Genes, Suppressor; Genes, bcl-2; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genetics, Gene Mapping; Genetics-Mutagenesis; Genome; Genome, Human; Genomics; Goals; Hematopoietic; Hexadecadrol; Hexadrol; Homolog; Homologous Gene; Homologue; Human; Human Genome; Human, General; Institutes; Knowledge; LEUKCL; Leukemia, T-Cell; Leukemic Cell; Life; Link; Linkage Mapping; Lokalison-F; Loverine; Lymphocytic Leukemia, T-Cell; Lymphoid Cell; Lymphoma, Follicular; Lymphoma, Giant Follicular; Lymphoma, Nodular; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Methods and Techniques; Methods, Other; Methylfluorprednisolone; Mice; Microfluorometry, Flow; Microscopic; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Millicorten; Modeling; Molecular; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Mutation; Mymethasone; Normal Cell; Ocasa; Oncogenes; Oncogenic; Orgadrone; Organ; P53; Pan; Pan Genus; Pan Species; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Point Mutation; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Preparation; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Family; Publishing; Radiation; Radiation therapy; Radiation, Whole-Body; Radiotherapeutics; Radiotherapy; Regulation; Research; Resistance; Reticuloendothelial System, Thymus; Role; Screening procedure; Second-Site Suppressor Genes; Specificity; Spersadex; Spersadox; Stimulus; Suppressor Genes; Suppressor Mutations; Syntenic Homology; Synteny; System; System, LOINC Axis 4; T-Cell Leukemia; T-Cells; T-Lymphocyte; T-Lymphocytic Leukemia; TP53; TP53 gene; TRP53; Techniques; Testing; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissues; Total Body Irradiation; Transforming Genes; Transgenes; Transgenic Organisms; Translocation, Genetic; Trust; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Vertebrate Animals; Vertebrates; Visumetazone; Whole-Body Irradiation; Zebra Danio; Zebra Fish; Zebrafish; anticancer therapy; auricularum; base; cancer cell; cancer therapy; carcinogenesis; ced9 homolog; cellular targeting; chemotherapy; chromosome dislocation; chromosome translocation; conventional therapy; design; designing; drug/agent; experiment; experimental research; experimental study; flow cytophotometry; gain of function; genetic mapping; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; in vivo; inhibitor; inhibitor/antagonist; interest; irradiation; malignancy; member; model organism; mouse model; mutant; necrocytosis; neoplasm/cancer; neoplastic cell; novel; overexpression; pathway; positional cloning; ray (radiation); research study; resistant; response; reverse genetics; screening; screenings; small molecule; social role; thymocyte; thymus derived lymphocyte; tool; transgenic; tumor; tumor suppressor; vertebrata; whole genome association studies; whole genome association study; zebrafish genome",Genetic Modifiers of the Anti-apoptotic Functions of Bcl-2,,119066,CAMP,Cancer Molecular Pathobiology Study Section,,5,303525,
7761317,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA119168-05,,NCI:349267;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"TAYLOR, KATHRYN L;",1862145;,5R01CA119168,03/01/2006,01/31/2011,"Active Follow-up; Address; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Area; Arm; Attitude; Base of Human Prostate; Base of the Prostate; Behavior; Belief; Benefits and Risks; Black Populations; Black or African American; Cancer of Prostate; Cancers; Cessation of life; Characteristics; Cognitive; Commit; Communities; Complex; Comprehension; Computer Literacy; Computers; Data; Death; Decision Aid; Decision Aids; Decision Making; Detection; Development; Disease; Disorder; Early Diagnosis; Education; Education for Intervention; Educational Intervention; Educational aspects; Effectiveness; Elderly; Elderly, over 65; Equilibrium; Evaluation; Future; Goals; HOSP; Health; Health Instruction; Health Training; Health Tutoring; Health education; History; Hospitals; Individual; Informed Consent; Instruction Intervention; Internet; Intervention; Intervention Strategies; Judgment; Knowledge; Knowledge acquisition; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Methods; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; On-Line Systems; Online Systems; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Participant; Patient Education; Patient Instruction; Patient Training; Patients; Persons; Phase; Primary Care; Primary Health Care; Primary Healthcare; Printing; Procedures; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Randomized; Randomized Controlled Trials; Recommendation; Recording of previous events; Relative; Relative (related person); Reporting; Research; Role; Sampling; Screening Result; Screening for Prostate Cancer; Screening procedure; Structure of base of prostate; Target Populations; Technology; Training Intervention; Upper arm; WWW; Washington; advanced age; aged; balance; balance function; base; black American; cancer diagnosis; cancer education; cohort; college; comparative efficacy; design; designing; disease/disorder; early detection; elders; follow-up; geriatric; health related quality of life; improved; innovate; innovation; innovative; instructional intervention; interest; interventional strategy; late life; later life; literate; male; malignancy; men; men's; neoplasm/cancer; novel; older adult; older person; online computer; primary outcome; programs; prostate cancer early detection; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; satisfaction; screening; screenings; senior citizen; social role; success; tool; treatment as usual; treatment effect; web; web based; world wide web",Internet-Based Education for Prostate Cancer Screening,,119168,CLHP,Community-Level Health Promotion Study Section,,5,349267,
7760066,R01,CA,5,,02/01/2010,01/31/2011,PA-04-157,5R01CA119911-04,,NCI:282150;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,DENTISTRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"MONTANER, SILVIA V;",8323688;,5R01CA119911,04/02/2007,01/31/2012,"Affect; Angiogenic Factor; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Apoptotic; Body Tissues; Buccal Mucosa; CDC; Cancer Genes; Cancer-Promoting Gene; Cancers; Causality; Cell Death, Programmed; Cell Survival; Cell Viability; Cells; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Clinical Management; Connective Tissue Sarcoma; Data; Development; Disease; Disorder; Endothelial Cells; Endothelium, Vascular; Etiology; Event; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Factor, Angiogenesis; G Protein-Complex Receptor; G-Protein-Coupled Receptors; GFAC; Genes; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guidelines; HHV-8; HHV8; Herpesviridae; Herpesviruses; Human; Human, General; In Vitro; Individual; Investigation; Investigators; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Lesion; Lytic; Maintenance; Maintenances; Malignant Neoplasms; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Soft Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular; Molecular Target; Mouth Mucosa; Multiple Hemorrhagic Sarcoma; Murine; Mus; Nature; Neoplasms; Oncogenes; Oncogenesis; Oncogenic; Oral Mucosa; Oral mucous membrane structure; Organ; Pathogenesis; Pathway interactions; Patients; Pattern; Prevention; Prevention therapy; Programs (PT); Programs [Publication Type]; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Research Personnel; Research Proposals; Researchers; Role; Sarcoma of the Soft Tissue and Bone; Sarcoma, Soft Tissue; Signal Pathway; Skin; TSC2; TSC2 gene; Therapeutic; Tissues; Transforming Genes; Tumor Cell; Tumors; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Vascular Endothelium; Viral; Viral Oncogene; Virus-HHV8; Visceral; base; cell transformation; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; herpes virus; human FRAP1 protein; human herpesvirus 8; in vivo; insight; mTOR; mTOR Signaling Pathway; malignancy; microarray technology; model organism; neoplasia; neoplasm/cancer; neoplastic cell; neoplastic growth; neovascular; novel; oral mucosae; oral mucosal; paracrine; pathway; programs; rapamycin and FKBP12 target 1 protein, human; research study; sarcoma; social role; therapeutic target; transformed cells; tumor; tumorigenesis",Molecular Targets for the Prevention and Treatment of Kaposi's Sarcoma,,119911,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,4,282150,
7771797,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA120315-03,,NCI:382896;,2010,NATIONAL CANCER INSTITUTE,,BERKELEY,UNITED STATES,BIOLOGY,09,078576738,US,CA,947208202,UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB,"SCHILD, DAVID ;",1928349;,5R01CA120315,03/07/2008,01/31/2012,"AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Activator Protein-1; Antibodies; Antimorphic mutation; Assay; BRCA2; BRCA2 Gene Product; BRCA2 Protein; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Biological Testing; Breast Cancer 2 Gene Product; Breast Cancer 2, Early Onset Protein; Breast Cancer Type 2 Susceptibility Protein; C-terminal; Cancer Induction; Cancer Radiotherapy; Cancers; Cell Cycle; Cell Division Cycle; Cell Line; Cell Lines, Strains; CellLine; Cells; Chickens; Chromatin; Chromosome Pairing; DNA Damage; DNA Damage Repair; DNA Injury; DNA Recombination; DNA Repair; DNA Repair Gene; DNA Repair Pathway; DNA recombination (naturally occurring); DNA repair protein; DNA-Binding Proteins; Defect; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; Enhancer-Binding Protein AP1; Environmental genotoxicant; Exposure to; FANCB; FANCD1; Frequencies (time pattern); Frequency; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Genes; Genetic Recombination; Genetics-Mutagenesis; Genome Stability; Goals; Human; Human Cell Line; Human, General; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Investigation; Kinases; Knock-out; Knockout; Letters; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Model System; Modeling; Models, Biologic; Molecular Biology, Mutagenesis; Mutagenesis; Nuclear; Pathway interactions; Phase; Phenotype; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Preventive; Proteins; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation; Radiation therapy; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Radiotherapeutics; Radiotherapy; Recombination; Recombination, Genetic; Roentgen Rays; Role; Sequence Homology; Sequence-Specific Posttranscriptional Gene Silencing; Sister Chromatid Exchange; Stability, Genomic; Staging; Synapsis; Synapsis, Chromosomal; System; System, LOINC Axis 4; TK1; TK1 gene; Testing; Time; Transcription Factor AP-1; Transphosphorylases; Two Hybrid; Unscheduled DNA Synthesis; Work; X-Radiation; X-Rays; Xrays; Yeast One Hybrid System; Yeast One/Two-Hybrid System; base; carcinogenesis; chemotherapy; cultured cell line; environmental mutagenesis; environmental mutagens; experiment; experimental research; experimental study; gene product; homology (molecular); in vivo; irradiation; malignancy; meetings; mutant; neoplasm/cancer; novel; paralog; paralogous gene; pathway; prevent; preventing; public health relevance; ray (radiation); repair; repaired; research study; response; shRNA; short hairpin RNA; small hairpin RNA; social role; tool; tumor; yeast two hybrid system",Determining the role of RAD51AP1: a new gene in DNA repair and genomic stability,,120315,RTB,Radiation Therapeutics and Biology Study Section,,3,382896,
7759204,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA120317-04,,NCI:292600;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,GENETICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"LAND, HARTMUT ;",6630113;,5R01CA120317,04/01/2007,01/31/2012,"Ablation; Adhesions; Affect; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; Apoptotic; Biochemical; Biochemical Pathway; Cancer Genes; Cancer Induction; Cancer Treatment; Cancer-Promoting Gene; Cancers; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Tumor Antigen P53; Clinical; Complex; Consensus; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Combinations; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Equilibrium; Event; GFAC; Genes; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HDAC Agent; Histone Deacetylase Inhibitor; Human; Human, General; In Vitro; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Intracellular Communication and Signaling; Investigation; Investigators; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Metabolic Networks; Mice; Molecular; Molecular Analysis; Motility; Motility, Cellular; Murine; Mus; Mutation; Nature; Normal Cell; Oncogenes; Oncogenic; Oncoprotein p53; P53; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein TP53; Protein p53; Proteins; Protocols, Treatment; RGM; Regimen; Regulation; Research; Research Personnel; Researchers; Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Subcellular Process; TP53; TP53 gene; TRP53; Testing; Transforming Genes; Transmission; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Work; anticancer therapy; balance; balance function; biological signal transduction; cancer cell; cancer progression; cancer therapy; carcinogenesis; cell behavior; cell motility; cell transformation; conventional therapy; experience; gene product; genome mutation; in vivo; inhibitor; inhibitor/antagonist; loss of function; loss of function mutation; malignancy; membrane structure; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic progression; p53 Antigen; p53 Tumor Suppressor; prevent; preventing; programs; resistant; response; rho; social role; trait; transformed cells; transmission process; tumor; tumor progression",Cooperation of oncogenic mutations in the control of malignancy,,120317,CAMP,Cancer Molecular Pathobiology Study Section,,4,292600,
7752849,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA120368-04,,NCI:256382;,2010,NATIONAL CANCER INSTITUTE,,HANOVER,UNITED STATES,NONE,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"POGUE, BRIAN WILLIAM;",2214755;,5R01CA120368,02/12/2007,12/31/2011,"Absorption; Address; Animals; Area; Artifacts; Biological; Bioluminescence; Blood; Blood Vessels; Body Tissues; Brain imaging; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancer Treatment; Cancer of Prostate; Cancers; Cell Communication and Signaling; Cell Signaling; Characteristics; Clinical; Common Rat Strains; Complex; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Coupling; Data; Development; Development Plans; Diagnosis; Diagnostic; Disease Progression; EMI scan; Future; Hemoglobin; Human; Human, General; Hydrogen Oxide; Image; Image Reconstructions; Implant; Industry; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Medical Imaging, Positron Emission Tomography; Medical Oncology; Medicine; Methods; Microscopic; Modeling; Molecular; Monitor; Morphologic artifacts; Nature; Noise; O element; O2 element; Optics; Organ; Oxygen; PET; PET Scan; PET imaging; PET/CT; PET/CT scan; PETSCAN; PETT; Pathologic; Pathology; Performance; Plans, Development; Positron Emission Tomography Scan; Positron-Emission Tomography; Pre-Clinical Model; Preclinical Models; Procedures; Process of absorption; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prostate CA; Prostate Cancer; Prostate Neoplasms; Prostatic Cancer; Prostatic Neoplasia; Prostatic Neoplasms; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Rat; Rattus; Reconstructions, Image; Relative; Relative (related person); Research; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Blood; Science of Medicine; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; Tag; Technology; Testing; Therapeutic; Therapeutic Studies; Therapy Research; Tissues; Tomodensitometry; Tomography, Xray Computed; Tracer; Translational Research; Translational Research Enterprise; Translational Science; Tumor of the Prostate; Vascular Permeabilities; Water; Work; X-Ray Computed Tomography; absorption; anticancer therapy; base; biological signal transduction; brain visualization; cancer therapy; catscan; computed axial tomography; computerized axial tomography; computerized tomography; density; design; designing; imaging; improved; in vivo; innovate; innovation; innovative; insight; malignancy; molecular imaging; neoplasm/cancer; novel; optic imaging; optical imaging; pre-clinical; preclinical; programs; reconstruction; response; soft tissue; stem; subcutaneous; tomography; translation research enterprise; trend; tumor; tumor growth; vascular",Micro CT/NIR Molecular Imaging of Cancer,,120368,BMIT,Biomedical Imaging Technology Study Section,,4,256382,
7759157,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA120386-04,,NCI:282150;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,UROLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"WANG, ZHOU ;",1861744;,5R01CA120386,04/01/2007,01/31/2012,"AML - Acute Myeloid Leukemia; Affect; Age-Months; Allelic Loss; Amino Acids; Androgenic Agents; Androgenic Compounds; Androgens; Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Blood (Leukemia); Cancer of Prostate; Cancers; Carcinoma of the Liver Cells; Cell Death, Programmed; Cellular Oncogene; Chromosomal dislocation; Chromosomal translocation; Clinical; Crossbreeding; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diagnosis; Disease-Free Survival; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysplasia; EAF1 protein, human; ELL associated factor 1 protein, human; ELL-associated factor; ELL-associated factor, human; Eating; Epithelial; Epithelial Cells; Event-Free Survival; Exhibits; Expression Profiling; Expression Signature; Family; Food Intake; Forecast of outcome; Foundations; Frequencies (time pattern); Frequency; Genbank; Gene Copy Number; Gene Dosage; Gene Expression; Gene Family; Genes; Genetics, in situ Hybridization; Genital System, Male, Prostate; Germinoblastoma; Gleason Grade; Gleason Grade for Prostate Cancer; Gleason Score; Gleason Score for Prostate Cancer; Gleason Sum; Gleason-SC; HCC; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Human; Human Prostate; Human Prostate Gland; Human, General; Hybridization, Genetic; Hyperplasia; Hyperplasia of Prostate Gland; Hyperplastic; In Situ Hybridization; Investigators; Knock-out; Knockout; Knockout Mice; L-Lysine; Lead; Leukemia, Myelocytic, Acute; Leukemias, General; Link; Loss of Heterozygosity; Lung Adenocarcinoma; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lysine; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Murine; Mus; Myeloblastic Leukemia, Acute; Myelogenous Leukemia, Acute; Null Mouse; Oncogene Activation; Organ; Outcome; Pathology; Pathway interactions; Pb element; Phenotype; Prevention; Prevention of Prostate CA; Prevention of Prostate Cancer; Primary carcinoma of the liver cells; Prognosis; Programs (PT); Programs [Publication Type]; Prostate; Prostate CA; Prostate CA Prevention; Prostate Cancer; Prostate Cancer Prevention; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Hyperplasia; Prostatic Neoplasia; Prostatic Neoplasms; Prostatic hypertrophy; Protein Family; Proteins; Proto-Oncogenes; Research Personnel; Research Specimen; Researchers; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Specimen; Testing; Therapeutic Androgen; Time; Tissue Arrays; Tissue Chip; Tissue Microarray; Transcription Activation; Transcriptional Activation; Transfection; Translocation, Genetic; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Tumor of the Prostate; Up-Regulation; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; aminoacid; base; c-ONC; cDNA Arrays; cDNA Microarray; cancer cell; cancer progression; cancer type; chromosome dislocation; chromosome translocation; clinical data repository; clinical data warehouse; data repository; dyscrasia; eleven nineteen lysine-rich leukemia gene-associated factor 1 protein, human; gene product; heavy metal Pb; heavy metal lead; human EAF1 protein; in situ Hybridization Staining Method; in vivo; leukemia; malignancy; member; molecuar profile; molecular signature; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; outcome forecast; overexpression; pathway; prognostic; programs; prostate cancer prevention; prostate carcinogenesis; prostate hyperplasia; protooncogene; relational database; response; social role; success; tumor progression; tumor suppressor",Role of Eaf family proteins in prostate carcinogenesis,,120386,CG,Cancer Genetics Study Section,,4,282150,
7754389,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA120451-04,,NCI:279300;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,DERMATOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"MUKHTAR, HASAN ;",1872096;,5R01CA120451,01/01/2007,12/31/2011,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; API4; Active Oxygen; Affect; Age-Years; American; American Cancer Society; Androgenic Agents; Androgenic Compounds; Androgens; Angiogenic Factor; Animal Model; Animal Models and Related Studies; Anthocyanins; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Apoptotic; Athymic Nude Mouse; Attention; Aubergine; Autocrine Systems; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Berry; Biological; Biological Function; Biological Process; Brinjal; CAP20 protein; CCND1 Protein; CDK; CDK Inhibitor Protein; CDK inhibitor p27; CDK-Interacting Protein 1; CDK2-associated protein 20 kDa; CDKI Protein; CDKN1 protein; CDKN1A; CDKN1A Protein; CDKN1B; CDKN1B protein; CDKN4 protein; CIP-1 Protein; CWR22Rv1; Cachectin Receptors; Cancer Cause; Cancer Etiology; Cancer Induction; Cancer Patient; Cancer Treatment; Cancer of Lung; Cancer of Prostate; Cancers; Carrot; Carrots - dietary; Cdk2 inhibitor protein; Cell Communication and Signaling; Cell Culture System; Cell Culture Techniques; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell-Death Protease; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Cip1 protein; Co-Stimulator; Costimulator; Cyclin D1; Cyclin Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor 1A; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; DNA Binding; DNA Binding Interaction; DU145; Data; Death; Development; Diagnosis; Dietary Intervention; Disease; Disease Progression; Disorder; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug resistance; EC 2.7; EPR-1; Eggplant; Ellagi-Tannins; Ellagitannins; Epidermal Thymocyte Activating Factor; Evaluation; Event; Factor, Angiogenesis; Family; Figs; Figs - dietary; Fruit; G1/S-Specific Cyclin D1; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Gene Transcription; Genes; Genetic; Genetic Transcription; Grapes; Green tea (dietary); Growth and Development; Growth and Development function; Heterograft; Human; Human, General; Hydrolyzable Tannins; I Kappa B A; I Kappa B-Alpha; I kappa B-alpha protein; IAP4; ICE-like protease; IGF-1; IGF-I; IGF-I-SmC; IGF1; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IL-2; IL2; IL2 Protein; INFLM; IkappaBalpha; Immunoglobulin Enhancer-Binding Protein; Implant; In Vitro; Incidence; Induction of Apoptosis; Inflammation; Inflammatory; Infusion; Infusion procedures; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intervention Studies; Intracellular Communication and Signaling; Investigation; Investigators; Juice; Kinases; Kip1 protein; LNCaP; Light; Lymphocyte Mitogenic Factor; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; MALDI-TOF Mass Spectrometry; MDA 6; MMP-2; MMP-9; MMP-9 Protein; MMP2; MMP9; MMPs; Macrophage Gelatinase; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Prostate; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Matrix-Assisted Laser Desorption Ionization Time-of-Flight MS; Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry; Mediating; Medical; Metastasis; Metastasis Induction; Metastasize; Metastatic Neoplasm; Metastatic Prostate Cancer; Metastatic Tumor; Mice; Mice, Athymic; Mice, Nude; Mitogenic Factor; Modeling; Molecular; Molecular Target; Murine; Mus; NF-Kappa B Inhibitor Alpha; NF-kB; NF-kappa B; NF-kappaB; NF-kappaB inhibitor alpha; NFKB; NFKBI; NFKBIA; Neoplasm Metastasis; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Nuclear Transcription Factor NF-kB; Nuclear Translocation; Nude Mice; Nutrition Interventions; Nutritional Interventions; Oncogenesis; Onions; Operation; Operative Procedures; Operative Surgical Procedures; Oral; Outcome Study; Oxygen Radicals; P21; P27KIP1; PC3 cell line; PEX; PRAD1 Protein; Pathway interactions; Phosphorylation; Phosphotransferases; Photoradiation; Pic-1 protein (cyclin); Pigments; Plants; Plants, General; Pomegranate; Population; Prevention; Prevention of Prostate CA; Prevention of Prostate Cancer; Preventive; Principal Investigator; Pro-Oxidants; Process; Production; Proliferation Marker; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Prostate CA; Prostate CA Prevention; Prostate Cancer; Prostate Cancer Prevention; Prostate Carcinoma Metastatic; Prostate Disease; Prostatic Cancer; Prostatic Diseases; Protein Family; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-1; Publishing; Pulmonary Cancer; Pulmonary malignant Neoplasm; Punica granatum; RNA Expression; Reactive Oxygen Species; Receptor Protein; Reporting; Research Personnel; Research Specimen; Researchers; Retroviridae; Retroviruses; Role; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin; Skin Carcinogenesis; Somatomedin C; Source; Specimen; Staging; Stimulus; Study, Outcome; Surgical; Surgical Interventions; Surgical Procedure; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNFR; Testing; Therapeutic; Therapeutic Androgen; Therapeutic Effect; Thymocyte Stimulating Factor; Tomatoes; Transcription; Transcription Factor NF-kB; Transcription, Genetic; Transgenic Organisms; Transphosphorylases; Transplantation, Heterologous; Trees; Tumor Cell; Tumor Cell Migration; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Type V Collagenase; United States; VEGFs; Vascular Endothelial Growth Factors; Vegf; Virus-Retrovirus; WAF-1 Protein; WAF1 CIP1; WAF1 protein; Work; Xenograft; Xenograft procedure; Xenotransplantation; angiogenesis; anti-oxidant; anticancer therapy; anticarcinogenic; autocrine; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c myc; c-bcl-1 Proteins; c-myc Genes; cancer cell; cancer chemoprevention; cancer metastasis; cancer prevention; cancer therapy; carcinogenesis; caspase; cdk Proteins; cdn1 protein; cell growth; cell type; chemoprevention of cancer; chemotherapy; cyclin D; cyclin G1; cyclin-dependent kinase Inhibitor p21; cyclin-dependent kinase inhibitor 1B; cystein protease; cystein proteinase; cysteine endopeptidase; delphinidin; design; designing; dietary fruit; disease/disorder; drug resistant; egg; experiment; experimental research; experimental study; fruits and vegetables; gene product; genetic manipulation; genetic promoter element; green tea; human disease; in vivo; inflammatory marker; inhibitor; inhibitor/antagonist; interest; kappa B Enhancer Binding Protein; keratinocyte; lung cancer; male; malignancy; mda-6 protein; member; men; men's; model organism; mouse model; mutant; necrocytosis; neoplasm/cancer; neoplastic cell; novel; nuclear factor kappa beta; oncoprotein p21; p21 cell cycle regulator; p21 cyclin kinase inhibitor; p21(cip1); p21(waf1-cip1); p21-WAF1; p27 Kip1 protein; p27 protein; p27(Kip); p27-Kip1; p27Kip1 protein; p40 protein (IkappaB-alpha); paracrine; pathway; pre-clinical; preclinical; prevent; preventing; prostate cancer cell line; prostate cancer prevention; prostate disorder; protein expression; protein p21; receptor; red wine; research study; resistance to Drug; resistant to Drug; response; senescent cell-derived inhibitor protein 1; social role; surgery; survivin; transcription factor; transgenic; tumor; tumor growth; tumorigenesis; ultraviolet; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",Pomegranate for Chemoprevention and Chemotherapy of Prostate Cancer,,120451,CDP,Chemo/Dietary Prevention Study Section,,4,279300,
7813866,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA120719-02,,NCI:365200;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,,07,078200995,US,WA,981091024,FRED HUTCHINSON CANCER RESEARCH CENTER,"BERETTA, LAURA ;",6629601;,5R01CA120719,05/01/2009,02/28/2014,"3-D; 3-Dimensional; Age; Albumins; Binding; Binding (Molecular Function); Biological; Blood Plasma; Blood Serum; Body Tissues; Carcinoma of the Liver Cells; Causality; Chemical Fractionation; Cirrhosis; Clinical; Complex; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Disorder; ELISA; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Etiology; FRACN; Fibrosis; Fractionation; Fractionation Radiotherapy; Gender; Gene Proteins; HCC; HCV; HCV infection; Hepatic Cirrhosis; Hepatic Disorder; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; High Prevalence; Human; Human, General; Individual; Investigators; Isoforms; Isotope Labeling; Lead; Length; Liver; Liver Cirrhosis; Liver diseases; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measures; Methods; Molecular Interaction; Molecular Weight; NANBH; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Pattern; Pb element; Photometry/Spectrum Analysis, Mass; Plasma; Plasma Proteins; Population; Primary carcinoma of the liver cells; Protein Binding; Protein Fragment; Protein Gene Products; Protein Isoforms; Protein Trafficking; Proteins; Proteome; Proteomics; Reporting; Research; Research Design; Research Personnel; Research Specimen; Researchers; Reticuloendothelial System, Serum, Plasma; Sampling; Scanning; Sensitivity and Specificity; Serum; Serum, Plasma; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Study Type; Technology; Therapeutic; Tissues; Traffickings, Protein; Validation; assay development; base; biomarker; body system, hepatic; chemokine receptor; cohort; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; early detection; gene product; heavy metal Pb; heavy metal lead; hepatitis non A non B; hepatitis nonA nonB; hepatopathy; insight; liver disorder; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; organ system, hepatic; protein expression; protein transport; public health relevance; study design; trend","Markers for HCV-related HCC: plasma profiling, targeted strategies and validation"," A trend of increasing rates of hepatocellular carcinoma (HCC) has been reported worldwide, that is related to  the high prevalence of hepatitis C virus (HCV) infection in the population. Better means for HCC diagnosis are  urgently needed. The purpose of this proposal is the development of a robust set of biomarkers for HCC that  could be used for early detection and diagnosis. ",120719,HBPP,Hepatobiliary Pathophysiology Study Section,,2,365200,
7749930,R01,CA,5,,01/01/2010,12/31/2010,,5R01CA120813-04,,NCI:263340;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,NEUROSURGERY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"HEIMBERGER, AMY BETH;",6102915;,5R01CA120813,01/10/2007,12/31/2013,"3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; APC; APRF protein; ATGN; Abscission; Acute-Phase Response Factor; Animal Model; Animal Models and Related Studies; Anthelone U; Antigen-Presenting Cells; Antigens; Apoptosis; Apoptosis Pathway; Astrocytoma, Grade IV; Attenuated; Blood Circulation; Blood Serum; Bloodstream; Bone-Derived Transforming Growth Factor; Brain; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; CTL; Causality; Cell Communication; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell physiology; Cell-Mediated Lympholytic Cells; Cell-to-Cell Interaction; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Circulation; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Development; Diffuse; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; EGF; Encephalon; Encephalons; Environment; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Essex brand of temozolomide; Etiology; Evaluation; Excision; Expression Profiling; Expression Signature; Extirpation; FLR; Failure (biologic function); Forecast of outcome; Functional disorder; Future; Generalized Growth; Generations; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hortega cell; Human; Human Urinary Gastric Inhibitor; Human, General; IL-10; IL10; IL10A; IL6-response factor; ITX; Immune; Immune Function, Cellular; Immune response; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunologic Accessory Cells; Immunologically Directed Therapy; Immunosuppressants; Immunosuppressive Agents; Immunotherapy; Impairment; In Vitro; Inbred C3H Mice; Inducer Cells; Infiltration; Interleukin 10 Precursor; Interleukin-10; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Knowledge; LIF-response factor; LYT3; Laboratories; Lead; Length of Life; Longevity; Lymphocyte; Lymphocytic; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Inbred C3H; Microglia; Microscopic; Milk Growth Factor; Modeling; Molecular Fingerprinting; Molecular Profiling; Monocytes / Macrophages / APC; Mouse, C3H; Murine; Mus; Natural Immunity; Neoplasms of Neuroglia; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neuroglial Neoplasm; Neuroglial Tumor; Newly Diagnosed; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pb element; Peptide Vaccines; Peptides; Phase 2 Clinical Trials; Phase II Clinical Trials; Phenotype; Physiopathology; Platelet Transforming Growth Factor; Population; Production; Prognosis; Progression-Free Survivals; QOL; Quality of life; RNA Splicing; Radiation; Recurrence; Recurrent; Regulatory T-Lymphocyte; Removal; Research; Research Personnel; Researchers; Resistance; Role; Schering brand of temozolomide; Schering-Plough brand of temozolomide; Secondary to; Serum; Signal Transducer and Activator of Transcription 3; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Stat3 protein; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survivals, Progression-Free; T-Cell Activation; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TGF B; TGF-beta; TGFbeta; Temodal; Temodar; Testing; Therapeutic Intervention; Thymus-Dependent Lymphocytes; Tissue Growth; Toxic effect; Toxicities; Transforming Growth Factor beta; Translations; Treatment Failure; Tumor Immunity; Tumors of Neuroglia; Urogastrone; Vaccination; Variant; Variation; Work; accessory cell; anergy; base; beta-Urogastrone; biological signal transduction; body system, allergic/immunologic; cancer type; chemotherapy; clinical investigation; cytokine; cytotoxic; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; failure; gitter cell; glioblastoma multiforme; heavy metal Pb; heavy metal lead; helper T cell; host response; imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-; immune function; immune therapy; immunogen; immunogenic; immunoresponse; immunosuppressive; improved; in vivo; intervention therapy; interventional strategy; life span; lifespan; lymph cell; mesoglia; methazolastone; microglial cell; microgliocyte; model organism; molecuar profile; molecular signature; ontogeny; organ system, allergic/immunologic; outcome forecast; pathophysiology; perivascular glial cell; phase 2 study; phase 2 trial; phase II trial; pre-clinical; preclinical; prevent; preventing; protocol, phase II; ray (radiation); resection; resistant; response; social role; spongioblastoma multiforme; standard of care; study, phase II; surgery; temozolomide; thymus derived lymphocyte; treatment strategy; tumor; tumor eradication; vaccination strategy",Modulation of Microglia and T Cell Interactions in Malignant Glioma,,120813,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,4,263340,
7761266,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA121114-03,,NCI:304917;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"MOSER, AMY RAPAICH;",1863456;,5R01CA121114,04/01/2008,01/31/2013,"Affect; Alleles; Allelomorphs; Alveolar; Apoptosis; Apoptosis Pathway; Backcrossings; Breast; Breast Neoplasms; Breast Tumors; Cancer Causing Agents; Cancer Staging; Cancer of Breast; Cancers; Candidate Disease Gene; Candidate Gene; Carcinogens; Carcinoma; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Death, Programmed; Cell Proliferative Activity; Cells; Cellular Proliferation Rate; Characteristics; Chromosome 4; Chromosomes, Human, Pair 4; Congenic Mice; DNA; Deoxyribonucleic Acid; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Disorder; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Exposure to; FVB Mouse; Female; Gene Components; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic analyses; Genetic defect; Genotype; Goals; Haplotypes; Hyperplasia; Hyperplastic; Infiltration; Inflammatory; Lesion; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Maps; Mice; Mice, Congenic; Microarray Analysis; Microarray-Based Analysis; Mitotic Index; Modeling; Molecular; Mouse Strains; Murine; Mus; Mutate; Mutation; Neoplasm Staging; Normal Cell; Oncogens; Pathway interactions; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Predisposition gene; Proliferation Index; Proteins; Recombinants; Regulation; Research Design; Role; S-Phase Fraction; Squamous Cell Epithelioma; Squamous cell carcinoma; Study Type; Sum; Susceptibility; Susceptibility Gene; T-Stage; Testing; Transcription Activation; Transcriptional Activation; Tumor Cell; Tumor Process; Tumor Staging; Tumor stage; Tumor-Associated Process; Up-Regulation; Variant; Variation; WNT Signaling Pathway; WNT signaling; Woman; angiogenesis; cell type; congenic; disease/disorder; epithelial carcinoma; gene function; gene product; genetic analysis; genome mutation; malignancy; malignant breast neoplasm; mammary; mammary tumor; microarray technology; molecular phenotype; mouse model; neoplasm/cancer; neoplastic cell; pathway; polymorphism; predisposing gene; public health relevance; social role; study design; treatment strategy; tumor",Analysis of Modifiers of Mammary Tumor Susceptibility,,121114,CG,Cancer Genetics Study Section,,3,304917,
7760117,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA121118-04,,NCI:189600;,2010,NATIONAL CANCER INSTITUTE,,LAS VEGAS,UNITED STATES,,01,557447690,US,NV,89135,NEVADA CANCER INSTITUTE,"HOLMEN, SHERI L;",6261839;,5R01CA121118,04/13/2007,01/31/2011,"21+ years old; 3,4-dihydroxyphenylalaninechrome tautomerase; 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(dimethyltriazeno)imidazole-4-carboxamide; Abscission; Adult; Asercit; Biologic Therapy; Biological Models; Biological Response Modifier Therapy; Biological Therapy; C4 a; C4a; Cancer Cause; Cancer Etiology; Cancers; Candidate Disease Gene; Candidate Gene; Cessation of life; Co-Stimulator; Complement 4a; Complement C4a; Complement component C4a; Costimulator; DTIC; DTIC Dome; DTICDome; Dacarbazina; Dacarbazine; Dacarbazine - DTIC; Dacatic; Dakarbazin; Death; Deticene; Detimedac; Development; Dimethyl (triazeno) imidazolecarboxamide; Dimethyl Imidazole Carboxamide; Dimethyl Triazeno Imidazole Carboxamide; Dimethyl-triazeno-imidazole-carboximide; Disease; Disease Marker; Disorder; Dopachrome isomerase; Drugs; Epidermal Thymocyte Activating Factor; Excision; Extirpation; Fauldetic; Forecast of outcome; Future; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome, Human; Goals; Human; Human Genome; Human, Adult; Human, General; ICDT; IL-2; IL2; IL2 Protein; Imidazole Carboxamide Dimethyltriazeno; Incidence; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Knowledge; Lymphocyte Mitogenic Factor; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Melanoma Cell; Metastasis; Metastasize; Metastatic Melanoma; Metastatic Neoplasm; Metastatic Tumor; Mice; Microarray Analysis; Microarray-Based Analysis; Mitogenic Factor; Model System; Modeling; Models, Biologic; Molecular Target; Mortality; Mortality Vital Statistics; Murine; Mus; Mutation; Neoplasm Metastasis; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pre-Clinical Model; Preclinical Models; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Public Health; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Recombinant Interferon; Refractory; Removal; Research; Retroviral Vector; Retroviridae; Retrovirus Vector; Retroviruses; SYS-TX; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Staging; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; System; System, LOINC Axis 4; Systemic Therapy; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; TRP-2; Technology; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Therapeutic Intervention; Thymocyte Stimulating Factor; Toxic effect; Toxicities; Translating; Translatings; Tumor Cell Migration; Tva protein; Tva receptor; Tyrosinase-Related Protein-2; United States; Virus-Retrovirus; Woman; adult human (21+); advanced disease; aged; base; biotherapeutics; biotherapy; cancer metastasis; caucasian American; chemotherapy; conventional therapy; cost; cytokine therapy; dimethyltriazenoimidazole carboxamide; disease control; disease/disorder; disorder control; dopachrome conversion factor; dopachrome oxidoreductase; dopachrome tautomerase; drug efficacy; drug/agent; gene product; genome mutation; intervention therapy; language translation; malignancy; melanocyte; melanoma; microarray technology; mid life; mid-life; middle age; middle aged; midlife; mouse model; neoplasm/cancer; novel; outcome forecast; public health medicine (field); recombinase; resection; surgery; therapeutic target; tumor; tva gene product; white American",A High-Throughput Model for Human Melanoma,,121118,CG,Cancer Genetics Study Section,,4,189600,
7746420,R01,CA,5,,01/23/2010,12/31/2010,PAS-04-079,5R01CA121258-04,,NCI:434515;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"KASAHARA, NORIYUKI ;",1870978;,5R01CA121258,03/12/2007,12/31/2011,"21+ years old; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 5-FC; 5-Fluorocytosine; Active Follow-up; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Adult; Adverse effects; Affect; Alcobon; Ancobon; Ancotil; Animals; Apoptosis; Apoptosis Pathway; Articulation; Assay; Astrocytoma, Grade IV; Athymic Nude Mouse; Bioassay; Biodistribution; Biologic Assays; Biological Assay; Blood Circulation; Bloodstream; Body Tissues; Bone Marrow Transplant; Bone Marrow Transplantation; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CTL; Cancer Genes; Cancer-Promoting Gene; Cancers; Cell Death, Programmed; Cell-Mediated Lympholytic Cells; Cells; Characteristics; Circulation; Clinical; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Common Rat Strains; Control Groups; Cytolysis; Cytolytic T-Cell; Cytosine Aminohydrolase; Cytosine deaminase; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; DNA Sequence Rearrangement; Development; Diffusion; Disease; Disorder; Drug Precursors; Emergent Technologies; Emerging Technologies; Encephalon; Encephalons; Engineering; Engineerings; Environment; Event; Exhibits; Extravasation; Fischer Rats; Flucytosine; Forecast of outcome; Future; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Grafting, Bone Marrow; HL-A Antigens; HLA Antigens; Heterograft; Human; Human Leukocyte Antigens; Human, Adult; Human, General; ITX; Image; Immune response; Immune system; Immunobiology; Immunocompetent; Immunodeficient Mouse; Immunologic, Luciferase; Immunologically Directed Therapy; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunophysiology; Immunosuppressants; Immunosuppressive Agents; Immunotherapy; Immunotherapy, Adoptive; Inbred F344 Rats; Individual; Injection of therapeutic agent; Injections; Intervention, Genetic; Investigators; Joints; Killings; Kinetic; Kinetics; Leakage; Leukocyte Antigens; Long Terminal Repeats; Luciferases; Lysis; Malignant Cell; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neoplasms; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Malignant Tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mediating; Methods; Mice; Mice, Athymic; Mice, Nude; Modeling; Molecular Biology, Gene Therapy; Mouse Leukemia Viruses; Murine; Murine leukemia virus; Mus; Needles; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Neurosurgeon; Normal Cell; Normal Tissue; Normal tissue morphology; Nude Mice; Oncogenes; Oncolytic; Patients; Penetration; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Preparation; Primary Brain Neoplasms; Principal Investigator; Pro-Drugs; Procedures; Prodrugs; Production; Prognosis; Programs (PT); Programs [Publication Type]; Radiation Surgery; Radiosurgery; Rat; Rats, F344; Rats, Inbred CDF; Rats, Inbred F344; Rats, Inbred Fischer 344; Rats, Inbred Fisher 344; Rattus; Rearrangement; Recruitment Activity; Research Personnel; Researchers; Retroviral Vector; Retroviridae; Retrovirus Vector; Retroviruses; Risk; Rodent Model; Safety; Serial Passage; Site; Solid Neoplasm; Solid Tumor; Spillage; Stereotactic External Beam Irradiation; Stereotactic Radiosurgery; Stereotaxic Radiosurgery; Suicide Gene Therapy; System; System, LOINC Axis 4; T-Lymphocytes, Cytotoxic; Technology; Terminal Repeats, Long; Testing; Therapeutic; Therapy, DNA; Tissues; Transforming Genes; Transgenes; Translations; Transplantation, Heterologous; Treatment Efficacy; Treatment Side Effects; Tumor Cell; Tumor Suppression; Tumor Suppression, Molecular; Tumors of Neuroglia; Viral; Virus; Virus-Retrovirus; Viruses, General; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; Yeasts; adoptive cell immunotherapy; adult human (21+); base; body system, allergic/immunologic; brain tissue; cancer cell; cell transduction; cellular transduction; chemotherapy; clinical applicability; clinical application; clinical investigation; cytokine; design and construction; disease/disorder; dosage; effective therapy; fluorocytosine; follow-up; gene therapy; gene transfer vector; genetic therapy; genotoxicity; glioblastoma multiforme; host response; imaging; immune therapy; immuno-gene therapy; immunogene therapy; immunoresponse; immunosuppressive; improved; in vivo; in vivo Model; long terminal repeat, nucleic acid; luminescence; malignancy; migration; molecular imaging; neoplasm/cancer; neoplastic cell; novel; organ system, allergic/immunologic; outcome forecast; phase 3 study; phase 3 trial; phase III trial; programs; protocol, phase III; quality assurance; recruit; response; side effect; spongioblastoma multiforme; study, phase III; subcutaneous; suicide gene; surgeon, neuro-; therapeutic efficacy; therapeutically effective; therapy adverse effect; trafficking; transduced cells; transduction efficiency; transfer of a gene; treatment adverse effect; tumor; tumors in the brain; vector",Cellular Transduction with Replication-Competent Retrovirus Vectors,,121258,GDD,Gene and Drug Delivery Systems Study Section,,4,434515,
7760675,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA121357-03,,NCI:351713;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,NONE,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"CHOREV, MICHAEL ;",8482691;,5R01CA121357,04/01/2008,01/31/2013,"Accreditation; Active Follow-up; Acute; Affect; Affinity; Anchorage-Independent Growth; Animal Model; Animal Models and Related Studies; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptotic; Assay; Azides; Binding; Binding (Molecular Function); Binding, Competitive; Bioassay; Bioavailability; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Blood Plasma; Breast Carcinoma; Cancer Cell Growth; Cancer Drug; Cancer Treatment; Cancers; Cap Binding Proteins; Carcinoma Cell; Cell Extracts; Cells; Cessation of life; Chemicals; Chemistry, Pharmaceutical; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clonal Expansion; Competitive Binding; Complex; Computer Simulation; Computerized Models; DNA Helicases; DNA Unwinding Proteins; DNA unwinding enzyme; Death; Development; Dissociation; Docking; Dose; Drug Evaluation, Preclinical; Drug Kinetics; Drug Screening; Drugs; Ectopic Expression; Epithelial Cells; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Figs; Figs - dietary; Fluorescence; Fluorescence Polarization; GFAC; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hand; Heterograft; High Throughput Assay; Hot Spot; Hot Spots (Area of Increased Mortality); Housekeeping; Housework; Housing; Human; Human, General; Hybrids; Hydrazones; In Vitro; Individual; Inhibition of Cancer Cell Growth; Initiation Factors; Isomerism; Laboratories; Lead; Libraries; Ligand Binding; Ligands; Location; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Epithelial Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammary Carcinoma; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measurement; Medication; Medicinal Chemistry; Messenger RNA; Methods; Modeling; Models, Computer; Models, Molecular; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Models; Molecular Stereochemistry; Molecular and Cellular Biology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouse Models of Human Cancer; Normal Cell; Nucleic Acid Biochemistry, Molecular Modeling; Oncogenic; Pathway interactions; Pb element; Peptide Initiation Factors; Peripheral; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacokinetics; Phenotype; Phosphorylation Site; Physiologic; Physiologic Availability; Physiological; Plasma; Play; Position; Positioning Attribute; Preclinical Drug Evaluation; Programs (PT); Programs [Publication Type]; Propionic Acids; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Public Health; RNA Cap-Binding Proteins; RNA, Messenger; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Recurrence; Recurrent; Research Proposals; Reticuloendothelial System, Serum, Plasma; Risk; Roentgen Rays; Role; Scaffolding Protein; Screening procedure; Serum, Plasma; Simulation, Computer based; Site; Specificity; Structure; Structure-Activity Relationship; Testing; Therapeutic; Time; Toxic effect; Toxicities; Translation Initiation; Translation Initiation Factor; Translational Initiation Factor; Translations; Transplantation, Heterologous; Triazoles; Tumor Suppressor Proteins; Tumor-Specific Treatment Agents; Tumorigenicity; X-Radiation; X-Rays; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; Xrays; anticancer agent; anticancer drug; anticancer therapy; base; bioavailability of drug; cancer therapy; chemical structure function; combinatorial; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; design; designing; drug candidate; drug development; drug/agent; efficacy testing; experiment; experimental research; experimental study; follow-up; gene product; heavy metal Pb; heavy metal lead; helicase; high throughput screening; human cancer mouse model; in silico; in vitro Assay; in vivo; inhibitor; inhibitor/antagonist; insight; isomer; mRNA; mRNA Cap Binding Proteins; malignancy; malignant phenotype; mammary; mimetics; model organism; molecular modeling; multidisciplinary; mutant; neoplasm/cancer; novel; overexpression; pathway; pharmacophore; pre-clinical; preclinical; prevent; preventing; programs; public health medicine (field); quantum; research study; restoration; scaffold; scaffolding; screening; screenings; small molecule; small molecule libraries; social role; structure function relationship; tool; tumor growth; tumor suppressor; virtual simulation",Development of Translation Initiation Inhibitors and their Anti-Cancer Activity,,121357,DMP,Drug Discovery and Molecular Pharmacology Study Section,,3,351713,
7759205,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA121850-03,,NCI:293198;,2010,NATIONAL CANCER INSTITUTE,,SYRACUSE,UNITED STATES,PHARMACOLOGY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"HUANG, YING ;",2094612;,5R01CA121850,04/01/2008,01/31/2013,"2 lysophosphatidylcholine acylhydrolase; Alimentary Canal; Antibodies; Autoregulation; Biological Function; Biological Process; Blotting, Western; Body Tissues; Cancers; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; Cellular Expansion; Cellular Growth; Cellular Proliferation; Cellular Regulation; Code; Coding System; Colon; Colon Cancer; Colon Carcinoma; Colon Neoplasms; Colon or Rectum; Colonic Carcinoma; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Colorectal; Complementary DNA; DNA, Complementary; Development; Diagnostic; Digestive Tract; Down-Regulation; Down-Regulation (Physiology); Downregulation; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Expression; Generalized Growth; Genetic; Growth; Homeostasis; Human; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Incidence; Laboratories; Lecithinase B; Lipase; Lipids; Lysolecithin-Lysolecithin Acyltransferase; Lysolecithinase; Lysophosphatidic Acids; Lysophospholipase; Lysophospholipids; MTGN; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Mice, Transgenic; Mitogens; Molecular; Molecular Marker of Prognosis; Molecular Mechanisms of Action; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Mutagenesis, Site-Directed; Mutate; Names; Normal Cell; Normal Tissue; Normal tissue morphology; Oncogenesis; Outcome Study; Phosphatides; Phospholipase B; Phospholipids; Physiologic; Physiological; Physiological Homeostasis; Prognosis Marker; Prognostic Marker; Proteins; RNA, Messenger; Research Specimen; Role; Signal Pathway; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specimen; Stability, mRNA; Study, Outcome; Targeted DNA Modification; Targeted Modification; Testing; Tissue Growth; Tissues; Transcript; Transgenic Mice; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Triad; Triad Acrylic Resin; Triad resin; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triolean Hydrolase; Tumor Cell; Tumor Suppressor Proteins; Tumor of the Colon; Western Blotting; Western Blottings; Western Immunoblotting; alimentary tract; base; cDNA; cancer cell; cell growth; cell growth regulation; colon cancer cell line; digestive canal; enzyme activity; gene product; mRNA; mRNA Expression; mRNA Stability; malignancy; molecular mass; mutant; neoplasm/cancer; neoplastic cell; novel; ontogeny; protein blotting; protein expression; public health relevance; social role; time interval; tributyrase; tumor; tumor suppressor; tumorigenesis",Role of a Novel Lysophospholipase in Tumorigenesis,,121850,TCB,Tumor Cell Biology Study Section,,3,293198,
7755381,R01,CA,5,,02/01/2010,01/31/2011,PA-06-167,5R01CA121851-04,,NCI:276442;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,DERMATOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SPIEGELMAN, VLADIMIR S;",8300970;,5R01CA121851,03/01/2007,01/31/2012,"American Cancer Society; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biology; Body Tissues; CHIP assay; Cancer Induction; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Cessation of life; ChIP (chromatin immunoprecipitation); Code; Coding System; Colon or Rectum; Colorectal; Colorectal Cancer; Colorectal Neoplasms; Data; Death; Decay, mRNA; Development; E3 Ligase; E3 Ubiquitin Ligase; Elements; Exhibits; Gene Expression; Genes; Goals; Hu antigen R; HuR protein; Human; Human Development; Human, General; IGF2; IGF2 gene; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Knockout Mice; Large Intestine Neoplasm; Large Intestine Tumor; Lead; MT-bound tau; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Neoplasm of the Large Bowel; Nucleic Acid Regulatory Sequences; Null Mouse; Oncogenesis; Pathway interactions; Pb element; Play; Prevention therapy; Programs (PT); Programs [Publication Type]; Proteins; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins; Radiation; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reporter; Research Personnel; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Small Interfering RNA; Stability, mRNA; Stimulus; Tissues; Tumor of the Large Bowel; Tumors, Colorectal; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Up-Regulation; Up-Regulation (Physiology); Upregulation; biological signal transduction; bowel; c myc; c-myc Genes; cancer cell; cancer prevention; carcinogenesis; chromatin immunoprecipitation; colorectal neoplasia; cytokine; design; designing; gene product; genetic regulatory element; heavy metal Pb; heavy metal lead; in vivo; knock-down; mRNA; mRNA Decay; mRNA Stability; malignancy; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; neoplasm/cancer; novel; pathway; programs; public health relevance; ray (radiation); response; siRNA; social role; tau; tau Proteins; tau factor; transcription factor; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",The Role of CRD-BP-regulated mRNA Stability in Colorectal Cancers,,121851,ZRG1,Special Emphasis Panel,,4,276442,
7752833,R01,CA,5,,02/01/2010,01/31/2011,PA-07-173,5R01CA121925-03,,NCI:342678;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MEANS, ROBERT E;",1946725;,5R01CA121925,04/01/2008,01/31/2013,"APC; Accounting; Adhesions; Antigen Presentation; Antigen-Presenting Cells; Antigens, Viral; Antimorphic mutation; Automobile Driving; B blood cells; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Biology; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C Type Lectin Receptors; CD209; CD209 gene; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD50 Antigen; CD54 (ICAM 1); CD54 Antigens; CDSIGN; CTL; Cancer Cause; Cancer Etiology; Cell surface; Cell-Mediated Lympholytic Cells; Cells; Cells, CD4; Cellular biology; Cis-Acting Locus; Cis-Acting Sequence; Cytolysis; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; DC-SIGN; DC-SIGN1; Data; Degradation Pathway; Degradative Pathway; Dendritic Cells; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drivings, Automobile; Drug Design; Endocytosis; Endothelial Cells; Family member; Future; Genes, Class I; Genes, MHC Class I; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); HHV-8; HHV8; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Herpesviridae Infections; Herpesviridae disease; Herpesvirus Infections; Histocompatibility Complex; Histocompatibility Complices; Homing; Human; Human, General; ICAM-1; ICAM-3; Immune; Immune Surveillance; Immune response; Immune system; Immunologic Accessory Cells; Immunologic Surveillance; Immunological Surveillance; Inducer Cells; Infection; Intercellular Adhesion Molecule 3; Intercellular adhesion molecule 1; Invaded; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Life; Lymph node proper; Lymphocyte antigen CD50; Lysis; MHC Class I; MHC Class I Genes; Major Histocompatibility Complex; Major Histocompatibility Complices; Man (Taxonomy); Man, Modern; Membrane Proteins; Membrane-Associated Proteins; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Oncogenesis; Pathogenicity; Pathology; Pathway interactions; Patients; Play; Population; Prevention; Prevention Measures; Prevention strategy; Preventive strategy; Production; Prophylactic treatment; Prophylaxis; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; RNA, Small Interfering; Receptor Protein; Receptors, C Type Lectin; Regulation; Regulatory T-Lymphocyte; Reticuloendothelial System, Lymph Node; Role; Site; Small Interfering RNA; Surface Proteins; Surveillances, Immunologic; Surveillances, Immunological; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocyte and NK-Cell; T-Lymphocyte and Natural Killer Cell; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; TLR protein; Thymus-Dependent Lymphocytes; Toll-like receptors; Transmission; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Vaccine Design; Veiled Cells; Viral; Viral Antigens; Viral Diseases; Virus; Virus Diseases; Virus-HHV8; Viruses, General; accessory cell; body system, allergic/immunologic; cell biology; cellular targeting; cytokine; driving; experiment; experimental research; experimental study; gene product; helper T cell; host response; human herpesvirus 8; immunoresponse; insight; intervention design; knock-down; lymph gland; lymph nodes; mutant; organ system, allergic/immunologic; pathogen; pathway; protein degradation; receptor; research study; response; siRNA; social role; stable cell line; therapy design; thymus derived lymphocyte; tool; trafficking; transmission process; treatment design; tumorigenesis; ubiquination; ubiquitin conjugation; viral detection; viral infection; virus antigen; virus detection; virus infection",Modulation of DC-SIGN and DC-SIGNR by KSHV,,121925,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,3,342678,
7755894,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA121951-08,,NCI:258272;,2010,NATIONAL CANCER INSTITUTE,,AUGUSTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"MOSKOFIDIS, DIMITRIOS ;",2095709;,5R01CA121951,08/01/2001,01/31/2012,"Ablation; Address; Advanced Development; Affect; Aging; Animal Model; Animal Models and Related Studies; Aorta; Apoptosis; Apoptosis Pathway; Biochemical Genetics; Blood Vessel Tumor; Blood Vessels; Bone Marrow; Breast Cancer Model; Cancer Biology; Cancers; Cardiovascular Diseases; Cell Communication and Signaling; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cessation of life; Chaperone; Clinical; Comparative Study; Cytoplasm; DISSEC; Data; Death; Development; Disease; Disorder; Dissection; Embryo Development; Embryogenesis; Embryonic Development; Endoplasmic Reticulum; Endothelial Cells; Ensure; Epithelial; Ergastoplasm; Experimental Designs; Gene Targeting; Generalized Growth; Genes, p53; Genetic, Biochemical; Germinoblastoma; Goals; Grant; Growth; HSP; Heat shock proteins; Human; Human Pathology; Human, General; Inhibition of Apoptosis; Intracellular Communication and Signaling; Investigators; Literature; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Molecular; Molecular Chaperones; Molecular Weight; Mother Cells; Murine; Mus; Mutant Strains Mice; Neoplasm Transplantation; Neoplasms in Vascular Tissue; Nerve Degeneration; Neuron Degeneration; Oncogenesis; P53; Pathway interactions; Physiologic; Physiological; Play; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Relative; Relative (related person); Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Stimulus; Stress; Stress Proteins; Subcellular Process; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Targetings, Gene; Technology; Testing; Therapeutic; Tissue Growth; Transgenic Mice; Tumor Angiogenesis; Tumor Cell; Tumor Protein p53 Gene; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Whole Organism; aberrant protein folding; abnormal protein folding; angiogenesis; base; biological adaptation to stress; biological signal transduction; blood vessel neoplasm; c myc; c-myc Genes; cancer progression; cardiovascular disorder; cell growth; cell transformation; chaperone machinery; combat; disease/disorder; experiment; experimental research; experimental study; gene product; heat shock transcription factor; human disease; in vivo; interest; knockout gene; malignancy; mammary cancer model; mammary tumor model; mitochondrial; model organism; mouse model; mouse mutant; mutant mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; neural degeneration; neurodegeneration; neuronal degeneration; ontogeny; pathologic protein folding; pathway; prevent; preventing; programs; protein folding; protein mis-folding; protein misfolding; reaction; crisis; repair; repaired; research study; response; senescent; social role; stress response; stress; reaction; transformed cells; tumor; tumor growth; tumor progression; tumor transplant; tumor transplantation; tumorigenesis; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; vascular; vasculogenesis",Function of HSPs in mouse models for human diseases,,121951,ZRG1,Special Emphasis Panel,,8,258272,
7758834,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA122226-04,,NCI:277400;,2010,NATIONAL CANCER INSTITUTE,,CHARLESTON,UNITED STATES,PHARMACOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SMITH, CHARLES D.;",1892625;,5R01CA122226,04/01/2007,01/31/2012,"Address; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Bioavailable; Biological Function; Biological Process; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer-Promoting Gene; Cancers; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell model; CellLine; Cells; Cellular Proliferation; Cellular model; Ceramide (lipids); Ceramides; Chemotherapeutic Agents, Neoplastic Disease; Drug Kinetics; Drug Resistance, Multiple; Drug Resistant, Multiple; Endothelial Cells; Goals; Human; Human, General; In Vitro; Intermediary Metabolism; Lead; METBL; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metabolic Processes; Metabolism; Methods; Mice; Modeling; Molecular Target; Multi-Drug Resistance; Multidrug Resistance; Murine; Mus; Oncogenes; Pb element; Pharmacokinetics; Phenotype; Property; Property, LOINC Axis 2; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Series; Sphingolipids; Structure-Activity Relationship; Therapeutic Agents; Toxic effect; Toxicities; Transforming Genes; Tumor Cell; Tumor-Specific Treatment Agents; VEGFs; Vascular Endothelial Growth Factors; Vegf; analog; angiogenesis; anti-cancer therapeutic; anticancer activity; anticancer agent; anticancer drug; anticancer therapeutic; anticancer therapy; cancer cell; cancer therapy; chemical structure function; computational chemistry; cultured cell line; cytotoxic; drug sensitivity; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; kinase inhibitor; malignancy; multi-drug resistant; multidrug resistant; neoplasm/cancer; neoplastic cell; novel; overexpression; resistant; response; social role; sphingosine 1-phosphate; sphingosine kinase; structure function relationship; tumor; tumor growth",Sphingosine Kinase as a Target for Cancer Therapy,,122226,DMP,Drug Discovery and Molecular Pharmacology Study Section,,4,277400,
7769467,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA122299-03,,NCI:345845;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"BENYA, RICHARD V;",1862472;,5R01CA122299,04/01/2008,01/31/2013,"(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol; 1,25-Dihydroxycholecalciferol Receptors; 1,25-Dihydroxyvitamin D3 Receptors; 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-; Aberrant crypt foci; Adenoma of the Colon; Adenomatous Polyp of the Colon; Affect; Animals; Attenuated; Azoxymethane; Biopsy; Blood Coagulation Factor IV; Blood Serum; Ca++ element; Calciol; Calcium; Cancer Cause; Cancer Causing Agents; Cancer Etiology; Cancer Staging; Cancers; Carcinogens; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; CellLine; Cellular Proliferation; Chemoprevention; Chemopreventive; Chemopreventive Agent; Cholecalciferol; Cholecalciferol Receptors; Coagulation Factor IV; Colon; Colon Cancer; Colon Carcinoma; Colonic Adenoma; Colonic Adenomatous Polyp; Colonic Carcinoma; Colonoscopy; Colorectal Cancer; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Diagnostic Neoplasm Staging; Diazene, dimethyl-, 1-oxide; Diet; Dietary Supplementation; Drugs; Endoscopic Biopsy; Enrollment; Enzymes; Epidemiology; Epithelial Cells; Equipment; Factor IV; Genetic Polymorphism; Human; Human, General; Hydroxylases; Hypercalcemia; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Injections, Subcutaneous; Instrumentation, Other; Intake; Lesion; Liquid substance; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mixed Function Oxidases; Mixed Function Oxygenases; Monooxygenases; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; Neoplasm Metastasis; Neoplasm Staging; Oncogens; PBO; Patient Self-Report; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Placebos; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Process; Publishing; Questionnaires; Receptor Activation; Receptor Gene; Receptors, 1,25-Dihydroxyvitamin D 3; Receptors, Calcitriol; Relative; Relative (related person); Research; Rodent; Rodentia; Rodentias; Screening for Colorectal Cancer; Secondary Neoplasm; Secondary Tumor; Self-Report; Serum; Sham Treatment; Subcutaneous Injections; Susceptibility; Time; Tumor Cell Migration; Tumor Staging; United States; VDR; VIT D; Vitamin D; Vitamin D 3; Vitamin D 3 Receptors; Vitamin D Analog; Vitamin D Receptors; Vitamin D3; Vitamin D3 Receptor; Vitamins; Woman; adenoma; anticarcinogenic; base; biomarker; cancer chemoprevention; cancer metastasis; cancer progression; cancer risk; chemoprevention of cancer; clinical data repository; clinical data warehouse; colorectal cancer screening; compound-1; cultured cell line; data repository; drug efficacy; drug/agent; early detection of colorectal cancer; enroll; fluid; instrumentation; liquid; malignancy; men; men's; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; patient population; polymorphism; prevent; preventing; receptor expression; relational database; sham therapy; tumor progression",Vitamin D and Colorectal Cancer,,122299,CDP,Chemo/Dietary Prevention Study Section,,3,345845,
7769844,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA122518-03,,NCI:321694;,2010,NATIONAL CANCER INSTITUTE,,NORFOLK,UNITED STATES,NONE,02,077945947,US,VA,23508,OLD DOMINION UNIVERSITY,"HELLER, RICHARD ;",1890055;,5R01CA122518,05/01/2008,02/28/2013,"Adverse effects; Animal Model; Animal Models and Related Studies; Animals; Antitumor Response; Biological; Biosynthetic Proteins; Blood Serum; Body Tissues; Cancers; Cells; Clinic; Clinical; Clinical Research; Clinical Study; Code; Coding System; Cutaneous; Data; Development; Disabled Persons; Disabled Population; Disease; Disorder; Dose; Effectiveness; Electroporation; Evaluation; Experimental Models; Experimental Models, Other; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Genes; Genes, Viral; Genetic Intervention; Genome; Goals; Growth; Handicapped; Health Status; IL-15; IL-15 Gene; IL15; IL15 Protein; IL15 gene; ITX; Immune; Immune response; Immune system; Immunologically Directed Therapy; Immunotherapy; Infirmity; Injection of therapeutic agent; Injections; Injections, Subcutaneous; Interleukin-15; Interleukin-15 Gene; Interleukin-15 Precursor; Interleukin-15 Precursor Gene; Intervention, Genetic; Intramuscular; Lead; Lesion; Level of Health; Liver; Local Therapy; Localized Lesion; Localized Therapy; Lung; MGC9721; MGC9721 Gene; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Melanoma Cell; Memory; Metastasis; Metastasize; Metastatic Melanoma; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Models, Experimental; Molecular Biology, Gene Therapy; Murine; Mus; Muscle; Muscle Neoplasms; Muscle Tissue; Myomatous Tumor; Myomatous neoplasm; Neoplasm Metastasis; Normal Tissue; Normal tissue morphology; Organ; Outcome; Pattern; Pb element; People with Disabilities; Persons with Disabilities; Plasmids; Population; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Protocols, Treatment; RGM; Recombinant Proteins; Recurrence; Recurrent; Regimen; Research; Research Proposals; Respiratory System, Lung; Role; Safety; Secondary Neoplasm; Secondary Tumor; Serum; Skin; Solid Neoplasm; Solid Tumor; Staging; Subcutaneous Injections; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Tail; Testing; Therapeutic; Therapeutic Agents; Therapy, DNA; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Tissues; Toxic effect; Toxicities; Translating; Translatings; Treatment Efficacy; Treatment Protocols; Treatment Regimen; Treatment Schedule; Treatment Side Effects; Tumor Cell; Tumor Cell Migration; Tumor of the Muscle; Vaccines; Veins; Viral Genes; Work; base; body system, allergic/immunologic; body system, hepatic; cancer metastasis; chemotherapeutic agent; cytokine; design; designing; disabled; disabled people; disease/disorder; fighting; gene therapy; genetic therapy; handicapping; handicapping condition; heavy metal Pb; heavy metal lead; host response; immune therapy; immunogenicity; immunoresponse; improved; in vivo; language translation; malignancy; melanoma; model organism; neoplasm/cancer; neoplastic cell; non-viral gene delivery; nonviral gene delivery; ontogeny; organ system, allergic/immunologic; organ system, hepatic; plasmid DNA; pre-clinical; preclinical; prevent; preventing; programs; public health relevance; pulmonary; response; side effect; social role; subcutaneous; therapeutic efficacy; therapeutically effective; therapy adverse effect; thymus derived lymphocyte; transfer of a gene; treatment adverse effect; tumor; tumor growth; vector",Therapeutic Potential of IL-15 Plasmid Delivery to Tumors Using Electroporation,,122518,GDD,Gene and Drug Delivery Systems Study Section,,3,321694,
7761278,R01,CA,5,,02/01/2010,01/31/2011,PA-05-086,5R01CA122726-04,,NCI:314260;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HOCK, HANNO R;",7879028;,5R01CA122726,04/01/2007,01/31/2012,"21+ years old; Adhesion Molecule; Adult; Alleles; Allelomorphs; Animal Tarsus; Assay; B blood cells; B-Cells; B-Lymphocytes; Bioassay; Biologic Assays; Biological Assay; Biology; Blood (Leukemia); Blood Precursor Cell; Body Tissues; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Cell Adhesion Molecules; Cell Count; Cell Cycle; Cell Division Cycle; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Number; Cell Process; Cell Proliferation; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Chimera; Chimera organism; Chronic; Complex; Defect; Development; Dysfunction; Embryo; Embryonic; Engineering; Engineerings; Exhibits; FLR; Failure (biologic function); Frequencies (time pattern); Frequency; Functional disorder; Gene Targeting; Gene Transfer; Genes, Viral; Grafting, Bone Marrow; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Hock; Homing; Human, Adult; Investigators; Kinetic; Kinetics; Leukemias, General; Lymphoid; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Marrow Transplantation; Mature B-Cell; Mature B-Lymphocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Molecular; Mother Cells; Mouse Strains; Murine; Mus; Pathway interactions; Phase; Phenotype; Physiopathology; Population; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Public Health; Regulation; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Staging; Stem cells; Structure-Activity Relationship; Subcellular Process; Suppressor Cells; Suppressor-Effector T-Lymphocytes; T Suppressor Cell; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocytes, Suppressor-Effector; Targetings, Gene; Therapeutic; Thymus-Dependent Lymphocytes; Tissues; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transplant Recipients; Transplantation; Viral Genes; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adult human (21+); base; cell adhesion protein; chemical structure function; failure; functional loss; leukemia; malignancy; neoplasm/cancer; novel; pathophysiology; pathway; progenitor; programs; public health medicine (field); response; self-renewal; social role; stem cell biology; structure function relationship; suppressor T lymphocyte; thymus derived lymphocyte; transcription factor; transfer of a gene; transplant; transplant patient",Function of zinc-finger transcription factor Gfi-1 in hematopoietic stem cells,,122726,HP,Hematopoiesis Study Section,,4,314260,
7756608,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA122910-04,,NCI:294500;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,GENETICS,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"REICH, NANCY C.;",1905956;,5R01CA122910,04/01/2007,01/31/2011,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; ATP[{..}]protein-tyrosine O-phosphotransferase; Animals; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; BRK; Biochemical; Biochemical Genetics; Biological; Biological Models; Blood (Leukemia); Breast Tumor Kinase; CIS protein; CIS-1 Protein; CISH; CISH Protein; Cancer Genes; Cancer Intervention; Cancer Model; Cancer Treatment; Cancer-Promoting Gene; CancerModel; Cancers; Cause of Death; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cellular Transformation; Clinical; Coupled; Cytokine Inducible SH2-Containing Protein; Cytokine Receptors; Cytokine-Inducible Inhibitor of Signaling Type 1B; Cytoplasm; DNA Binding; DNA Binding Interaction; Development; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Equilibrium; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Family member; G18; Genentech brand of trastuzumab; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Techniques; Genetic defect; Genetic, Biochemical; Germinoblastoma; Gleevec; Glivec; HEK3; Herceptin; Hoffman-La Roche brand of trastuzumab; Hormone Receptor; Human; Human, General; Image; Immunocompetent; Import, Nuclear; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Karyopherins; Knowledge; Leukemias, General; Life; Link; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Model System; Modeling; Models, Biologic; Multiple Myeloma; Murine; Mus; Mutation; Myeloma, Plasma-Cell; Neoplasms; Nuclear; Nuclear Import; Nucleus; Oncogenes; Oncogenesis; Oncogenic; PTK; PTK6; PTK6 Protein Tyrosine Kinase 6; PTK6 gene product, human; Phosphorylation; Phosphorylation Inhibition; Play; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Radiation Surgery; Radiosurgery; Receptors, Cytokine; Regulation; Reticulolymphosarcoma; Roche brand of trastuzumab; Role; SOCS; STAT protein; STAT3; STAT3 gene; Sarcoma, Germinoblastic; Signal Transducer and Activator of Transcription; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Stereotactic External Beam Irradiation; Stereotactic Radiosurgery; Stereotaxic Radiosurgery; Suppressor of Cytokine Signaling; TAM; Tamoxifen; Technics, Genetic; Testing; Transforming Genes; Translational Research; Translational Research Enterprise; Translational Science; Transportins; Tumors; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine-Protein Kinase 6; Tyrosine-Protein Kinase BRK; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; anticancer therapy; balance; balance function; biological signal transduction; brk protein, human; cancer therapy; carrier (molecular); cell imaging; cellular imaging; chemotherapy; cytokine; design; designing; genome mutation; human breast tumor kinase; human protein tyrosine kinase brk; hydroxyaryl protein kinase; imaging; inhibitor; inhibitor/antagonist; interventional strategy; leukemia; malignancy; metaplastic cell transformation; myeloma; myelomatosis; neoplasia; neoplasm/cancer; neoplastic growth; non-receptor PTK brk, human; overexpression; protein tyrosine kinase brk, human; social role; trafficking; transcription factor; translation research enterprise; tumor; tumor growth; tumorigenesis; tyrosyl protein kinase",Regulation of STAT3 Signaling,,122910,CAMP,Cancer Molecular Pathobiology Study Section,,4,294500,
7753227,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123067-04,,NCI:286900;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"CHANDEL, NAVDEEP S.;",1953933;,5R01CA123067,04/01/2007,01/31/2012,"ATF; Active Oxygen; Antioxidants; Biological; Blood Vessels; Cancer Treatment; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Coenzyme Q-Cytochrome-c Reductase; Coenzyme QH2-Cytochrome-c Reductase; Collagen Lysyl Oxidase; Complex III; Cytochrome b-c2 Oxidoreductase; Development; Dihydroubiquinone-Cytochrome-c Reductase; EC 1.4.3.13; Electron Transport Complex III; Enzymes; FLR; Failure (biologic function); Gene Transcription; Generalized Growth; Generations; Genes; Genetic Transcription; Glycolysis; Growth; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Hypoxia; Hypoxic; Intermediary Metabolism; Intracellular Communication and Signaling; Iron-Sulfur Proteins; LOX; Lysyl Oxidase; MAPK Signaling Pathway; MAPK Signaling Pathway Pathway; METBL; Malignant; Malignant - descriptor; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Metabolic Processes; Metabolism; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mitochondria; Molecular; Neoplasm Metastasis; Nutrient; O element; O2 element; Oncogenesis; Oxygen; Oxygen Deficiency; Oxygen Radicals; Pro-Oxidants; Proliferating; Protein-L-lysine[{..}]oxygen 6-oxidoreductase (deaminating); Protein-Lysine 6-Oxidase; Proteins; QH(2)-Cytochrome-c Reductase; QH(2)-Ferricytochrome-c Oxidoreductase; RNA Expression; Reactive Oxygen Species; Regulation; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Solid Neoplasm; Solid Tumor; Testing; Tissue Growth; Transcription; Transcription, Genetic; Tumor Cell; Tumor Cell Migration; Ubihydroquinone-Cytochrome-c Reductase; Ubiquinol-Cytochrome-c Reductase; Ubiquinol-ferricytochrome-c oxidoreductase; Ubiquinone-Cytochrome b-c2 Oxidoreductase; VEGFA; VEGFs; Vascular Endothelial Growth Factor Gene; Vascular Endothelial Growth Factors; Vegf; Vegf gene; activating transcription factor; angiogenesis; anti-oxidant; anticancer therapy; biological signal transduction; cancer metastasis; cancer progression; cancer therapy; cell growth; failure; gene product; hypoxia inducible factor 1; mitochondrial; neoplasm progression; neoplastic cell; neoplastic progression; novel therapeutic intervention; ontogeny; prevent; preventing; response; sensor; tumor; tumor growth; tumor progression; tumorigenesis; vascular",Mitochondrial regulation of hypoxic signaling in tumor cells,,123067,TPM,Tumor Progression and Metastasis Study Section,,4,286900,
7759150,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123071-04,,NCI:352111;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,BIOCHEMISTRY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"HALTIWANGER, ROBERT S.;",8072627;,5R01CA123071,04/01/2007,01/31/2012,"21+ years old; ADAMTS; Ablation; Adipocyte Membrane Protein p88; Adult; Affect; Alleles; Allelomorphs; Anthelone U; Bears; Biological Function; Biological Process; Body Tissues; CD36; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor); CD36 Antigens; CD36 Fatty Acid Transporter; CD36 gene; CSVTCG-Specific Receptor; CSVTCG-Specific TSP-1 Receptor; Cancers; Cell Communication and Signaling; Cell Signaling; Cell Surface Proteins; Cell surface; Cells; Characteristics; Consensus Sequence; ConsensusSequence; Cysteine; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; Deoxygalactose; Development; Drosophila; Drosophila genus; EGF; ES Cell Line; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Embryonic Stem Cell Line; Enzymes; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Esteroproteases; Event; FAT (Fatty Acid Translocase) - CD36 Antigen; Family; Family member; Fruit Fly, Drosophila; Fucose; Fucosyltransferase 1; Future; GP3B; GP4; GPIIIb Platelet Glycoprotein; GPIV; GPIV Platelet Glycoprotein; Galactoside 2-alpha-L-fucosyltransferase 1; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Glycans; Golgi; Golgi Apparatus; Golgi Complex; Half-Cystine; Hereditary; Heterozygote; Homozygote; Human Urinary Gastric Inhibitor; Human, Adult; In Vitro; Inherited; Intracellular Communication and Signaling; Investigators; L-Cysteine; Lead; Location; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Maps; Metabolic Glycosylation; Mice; Modification; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Mutation; OKM5 Antigen; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Physiologic; Physiological; Platelet Glycoprotein IIIb; Platelet Glycoprotein IV; Platelet Membrane Glycoprotein IIIb; Platelet Membrane Glycoprotein IV; Play; Polysaccharides; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Programs (PT); Programs [Publication Type]; Proteases; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteinases; Proteins; Proteins, Cell Surface; Proteolytic Enzymes; Purpura, Thrombocytopenic; Purpura, Thrombopenic; Quality Control; Receptor Protein; Regulation; Research Personnel; Researchers; Role; SCARB3; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Staging; Syndrome; THBS1; TSP; TSP-1; TSP1; Thrombocytopenic Purpura; Thrombospondin 1; Thrombospondin Receptors; Time; Tissues; Urogastrone; Ursidae; Ursidae Family; Weaning; adult human (21+); alpha-Fucose; beta-Urogastrone; biological signal transduction; clinical data repository; clinical data warehouse; data repository; design; designing; fruit fly; gastrulation; gene product; genome mutation; glycosylation; heavy metal Pb; heavy metal lead; human disease; in vivo; malignancy; member; mutant; neoplasm/cancer; notch; notch protein; notch receptors; novel; pathway; programs; protein folding; protein function; receptor; relational database; social role; vector",Glycosylation of Thrombospondin Type 1 Repeats,,123071,ZRG1,Special Emphasis Panel,,4,352111,
7771690,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123197-04,,NCI:459161;,2010,NATIONAL CANCER INSTITUTE,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"ZHOU, TONG ;",1972210;,5R01CA123197,04/20/2007,01/31/2012,"(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex; APO2; APO2 Ligand; APO2L; Address; Adriablastin; Adriablastine; Adriacin; Adriamycin PFS; Adriamycin RDS; Adriblastin; Adriblastina; Adriblastine; Adrimedac; Affect; Anzatax; Apo-2 Ligand; Apo-2L; Apoptosis; Apoptosis Pathway; Apoptotic; Applications Grants; Asotax; Assay; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Boxing; Bristaxol; CBDCA; Cancer Patient; Cancer cell line; Cancer of the Ovary; Cancers; Carboplatin; Carboplatino; Carcinoma of Ovary; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Line, Tumor; Cell Signaling; Cell surface; Cessation of life; Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Combination Drug Therapy; Combined Modality Therapy; Complex; DOXO-CELL; DR4; DR5; Data; Death; Death Domain; Development; Doxolem; Doxorubin; Drugs; Engineering; Engineerings; Exhibits; Expression Profiling; Expression Signature; Farmiblastina; Funding; Future; Goals; Grant Proposals; Grants, Applications; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; K-Awards; K-Series Research Career Programs; KILLER; KILLER/DR5; Liposomal Adriamycin; Liver Cells; Lytotoxicity; MGC9365; Malignant Cell; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Methods and Techniques; Methods, Other; Mice; Moab, Clinical Treatment; Modeling; Molecular Fingerprinting; Molecular Profiling; Molecular Target; Monoclonal Antibodies; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Normal Cell; Ovarian Carcinoma; Ovarian Tumor; Ovary Neoplasms; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Patient Selection; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Play; Polychemotherapy; Praxel; Predisposition; Programs (PT); Programs [Publication Type]; Protein Family; Proteins; Proteomics; Protocol; Protocols documentation; RNA Helicase; Receptor Protein; Regulation; Regulatory Protein; Reproduction spores; Research Career Program; Research Career Programs, K-Series; Research Personnel; Researchers; Resistance; Role; Rubex; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Spores; Staging; Susceptibility; TL2; TNF-Related Apoptosis Inducing Ligand TRAIL; TNF-related apoptosis-inducing ligand; TNFRSF10A; TNFRSF10A gene; TNFRSF10B; TNFRSF10B gene; TNFSF10; TNFSF10 Protein; TRAIL Protein; TRAILR-1; TRAILR1; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Techniques; Technology; Therapeutic; Tissue Slice Technology; Tissues; Toxic effect; Toxicities; Treatment Efficacy; Tumor Cell; Tumor Cell Line; Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor of the Ovary; Work; Xenograft Model; ZTNFR9; adriamycin; biological signal transduction; biomarker; cancer cell; chemotherapeutic agent; chemotherapy; cis-Diammine(cyclobutanedicarboxylato)platinum II; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); clinical efficacy; clinical investigation; combination pharmacotherapy; combination therapy; combined modality treatment; combined treatment; cytotoxicity; drug/agent; gene product; genetic regulatory protein; in vivo; industry partner; malignancy; molecuar profile; molecular signature; multimodality therapy; necrocytosis; neoplasm/cancer; neoplastic cell; novel; ovarian cancer; ovarian neoplasm; pathway; platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); preclinical study; programs; protein complex; protein profiling; receptor; regulatory gene product; resistant; response; social role; therapeutic efficacy; therapeutically effective; treatment strategy; tumor",Death Receptor-mediated Apoptosis and Therapy Strategies in Ovarian Cancer,,123197,CONC,Clinical Oncology Study Section,,4,459161,
7754073,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123203-04,,NCI:277400;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,OTHER BASIC SCIENCES,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"HASTY, EDWARD PAUL;",1889552;,5R01CA123203,04/01/2007,01/31/2012,"3 Prime Repair Exonuclease 1 Gene; 3' exonuclease; 5'-Exonuclease; 5'-Nucleotidephosphodiesterase; ATR-Interacting Protein Gene; ATRIP; ATRIP Gene; Abscission; Address; Aging; Alkaline Phosphodiesterase; Alkaline Phosphodiesterase I; Amino Acids; BRCA2; BRCA2 gene; Bacteriophage T4; Biochemical; Biological; Biological Function; Biological Process; Breast Cancer 2 Gene; Breast Cancer 2, Early Onset Gene; Breast Cancer Type 2 Susceptibility Gene; COCA1; Cancer of Breast; Cancers; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chromosomal Rearrangement; Coliphage T4; Colorectal Cancer; DKFZp434J0310 Gene; DNA; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Repair; DNA Replication; DNA Synthesis; DNA biosynthesis; DNase III Gene; DRN3 Gene; Data; Defect; Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like Gene; Deoxyribonucleic Acid; E coli; ES cell; Enterobacteria phage T4; Escherichia coli; Excision; Exhibits; Exonuclease; Extirpation; FANCB; FANCD1; FCC1; FLJ12343 Gene; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genome Instability; Genome Stability; Genomic Instability; Goals; HNPCC; HNPCC1; Hereditary Breast Cancer 2; Homologous Protein; Human; Human, General; Incidence; Knockout Mice; Length of Life; Longevity; Lymphocytes, Null; MMR; MSH2; MSH2 gene; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mismatch Repair; Murine; Mus; Mutant Strains Mice; Mutate; Mutation; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Nucleotides; Null Cells; Null Lymphocytes; Null Mouse; Oligonucleate 5'-Nucleotidohydrolase; Orthophosphoric Diester Phosphohydrolase; P53; Phenotype; Phosphodiesterase I; Physiologic; Physiological; Post-Replication Mismatch Repair; Protein Homolog; ProteinHomolog; Proteins; Publishing; RNA, Small Interfering; Removal; Robertsonian Translocation; Senescence; Small Interfering RNA; Stability, Genomic; Structure-Activity Relationship; Subcellular Process; Surgical Removal; T4 Phage; TP53; TP53 gene; TREX1; TREX1 gene; TREX2; TREX2 gene; TRP53; Testing; Three Prime Repair Exonuclease 1 Gene; Time; Tumor Protein p53 Gene; Tumor Suppressor Proteins; UIP1; Unscheduled DNA Synthesis; XQ28ORF; Yeasts; age dependent; age related; aminoacid; base; brca 2 gene; cancer genomics; cancer prevention; cancer risk; chemical structure function; cross-link; crosslink; embryonic stem cell; gene product; genome mutation; homologous recombination; improved; in vitro Assay; in vitro activity; in vivo; insight; life span; lifespan; malignancy; malignant breast neoplasm; mouse mutant; mutant; neoplasm/cancer; nervous system disorder; neurological disease; phosphodiesterase II; repair; repaired; resection; response; senescent; siRNA; spleen exonuclease; spleen phosphodiesterase; stem cell of embryonic origin; structure function relationship; tumor suppressor",Discovering TREX1 and TREX2 Function in Mammalian Cells and Mice,,123203,CG,Cancer Genetics Study Section,,4,277400,
7759116,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA123249-03,,NCI:313533;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","CHIEN, JEREMY ;SHRIDHAR, VIJI  (contact);",7126352 (contact);8767025;,5R01CA123249,04/01/2008,01/31/2013,"(SP-4-2)-Diamminedichloroplatinum; Anchorage-Independent Growth; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Anzatax; Apaf-3 protein; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; Asotax; Blotting, Western; Bristaxol; CASP-3; CASP3; CASP9 Protein; CDDP; CDR; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cancer Treatment; Cancer cell line; Cancer of the Ovary; Cancers; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase 9, Apoptosis-Related Cysteine Protease; Caspase Inhibitor; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Transformation, Neoplastic; Cell-Death Protease; CellLine; Cells; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Co-Immunoprecipitations; Combination Chemotherapy Regimen; Cysplatyna; Cysteine Protease CPP32; Cytidine, 2'-deoxy-; Cytosine Deoxyribonucleoside; Cytosine Deoxyriboside; DDP; Data; Deoxycytidine; Development; Diagnosis; Diagnostic; Dichlorodiammineplatinum; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug resistance; Drugs; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Esteroproteases; Family; Fluorogenic Substrate; Generalized Growth; Genomics; Growth; Hypermethylation; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; ICE-like protease; In Vitro; Lead; Lytotoxicity; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Mch6 protein; Mediating; Medication; Methods; Methylation; Mitochondria; Modification; Molecular; Neoplastic Cell Transformation; Oncogenesis; PARP Cleavage Protease; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Patients; Pattern; Pb element; Peptidases; Peptide Hydrolases; Peptide Library; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Play; Praxel; Primary Neoplasm; Primary Tumor; Process; Procollagen; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteases; Protein Methylation; Proteinases; Proteolytic Enzymes; Quimioterapia; Regulation; Resistance; Role; SCA-1; SREBP Cleavage Activity 1; Screening procedure; Serine Endopeptidase Inhibitors; Serine Endopeptidases; Serine Protease; Serine Protease Inhibitors; Serine Protein Hydrolases; Serine Proteinase Antagonists; Serine Proteinase Inhibitors; Serine Proteinases; Site; Staining method; Stainings; Stains; Stress; Substrate Specificity; Substrate, Fluorogenic; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Tissue Growth; Two Hybrid; Up-Regulation; Up-Regulation (Physiology); Upregulation; Western Blotting; Western Blottings; Western Immunoblotting; Woman; Yama; Yama protein; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; abstracting; anticancer therapy; base; bisulfite; cancer cell; cancer chemotherapy; cancer therapy; caspase; caspase-3; caspase-9; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; clinical remission; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytotoxicity; disease/disorder; drug resistant; drug/agent; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hydrogen sulfite; hydrosulfite; improved; in vivo; insight; malignancy; member; mitochondrial; model organism; mutant; necrocytosis; neoplasm/cancer; neoplastic transformation; novel; novel therapeutic intervention; ontogeny; ovarian cancer; pathway; pro-apoptotic protein; protein blotting; research study; resistance to Drug; resistant; resistant to Drug; response; screening; screenings; social role; tool; tumor; tumorigenesis; validation studies; vector; yeast two hybrid system",Regulation of Serine Protease HtrA1 and Chemoresponse,,123249,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,313533,
7760644,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123391-04,,NCI:295450;,2010,NATIONAL CANCER INSTITUTE,,PISCATAWAY,UNITED STATES,PHARMACOLOGY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"ZHENG, XIAOFENG STEVEN;",6193122;,5R01CA123391,04/01/2007,01/31/2012,"Accounting; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogene Protein p53; Antiproliferative Agents; Antiproliferative Drugs; Area; BZS; Biogenesis; Bryophyta; Bryophyte; Cancer Drug; Cancers; Cell Components; Cell Count; Cell Growth in Number; Cell Multiplication; Cell Nucleolus; Cell Number; Cell Proliferation; Cell Structure; Cells; Cellular Expansion; Cellular Growth; Cellular Oncogene; Cellular Proliferation; Cellular Structures; Cellular Tumor Antigen P53; Chemotherapeutic Agents, Neoplastic Disease; Clinical Trials; Clinical Trials, Unspecified; Consumption; Cytoplasm; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7.7.6; Employee Strikes; GFAC; Gene Products, RNA; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; Lead; MHAM; MMAC1; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Molecular Biology, Recombinant DNA; Mosses; Neuroblastoma of the Retina; Neuroblastoma, Retinal; Nuclear; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nutrient; Oncogene Products; Oncogene Proteins; Oncogenesis; Oncoprotein p53; Oncoproteins; Origin of Life; P105-RB; PP110; PTEN; PTEN gene; PTEN1; Pb element; Peptide Biosynthesis, Ribosomal; Phosphatase and Tensin Homolog; Phosphoprotein P53; Phosphoprotein pp53; Plasmosome; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Protein TP53; Protein p53; Proteins; Proto-Oncogenes; RB1; RNA; RNA Expression; RNA Polymerases; RNA, Non-Polyadenylated; Rapamune; Rapamycin; Rapamycin-Binding Proteins; Rb Gene Product; Rb Protein; Rb1 Gene Product; Recombinant DNA; Resistance; Retinoblastoma; Retinoblastoma Associated Protein; Retinoblastoma Protein; Ribonucleic Acid; Ribosomal RNA; Ribosomes; Sirolimus; Site; Strikes; Strikes, Employee; Structure; TP53; Therapeutic; Tissue Growth; Transcription; Transcription, Genetic; Tumor Cell; Tumor Protein p53; Tumor Suppressor Proteins; Tumor-Specific Treatment Agents; anti-cancer therapeutic; anticancer agent; anticancer drug; anticancer therapeutic; c-ONC; cancer cell; cell growth; clinical investigation; condensin; gene product; heavy metal Pb; heavy metal lead; malignancy; neoplasm/cancer; neoplastic cell; nucleolus; ontogeny; p53 Antigen; p53 Tumor Suppressor; pRB; prevent; preventing; protein synthesis; protooncogene; rDNA; rRNA; resistant; tumor suppressor; tumorigenesis",Growth Control and Anti-Cancer Mechanisms,,123391,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,4,295450,
7754039,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA123396-04,,NCI:234840;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"PRINS, ROBERT M;",6777166;,5R01CA123396,04/01/2007,01/31/2011,"1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-; 3M Brand of Imiquimod; APC; Agonist; Aldara; Animal Model; Animal Models and Related Studies; Antigen-Presenting Cells; Antigenic Determinants; Autologous; Binding Determinants; Biodistribution; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CD8; CD8B; CD8B1; CD8B1 gene; CNS Tumor; CNS neoplasm; CTL; Cancer Treatment; Cell model; Cell-Mediated Lympholytic Cells; Cellular model; Central Nervous System; Central Nervous System Neoplasms; Clinical; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Dendritic Cells; Dendritic cell activation; Epitopes; Epitopes, T-Lymphocyte; Generalized Growth; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Growth; Human; Human, General; ITX; Image; Imiquimod; Immune response; Immune system; Immunity; Immunologic Accessory Cells; Immunologic, Immunochemical; Immunologically Directed Therapy; Immunologics; Immunotherapy; In Vitro; Investigators; LYT3; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammals, Mice; Man (Taxonomy); Man, Modern; Memory; Method LOINC Axis 6; Methodology; Mice; Mice, Transgenic; Mission; Modeling; Monocytes / Macrophages / APC; Murine; Mus; Neoplasms; Neoplasms of Neuroglia; Nervous System, CNS; Neuraxis; Neuroglial Neoplasm; Neuroglial Tumor; Patients; Peptides; Peripheral; Physiologic pulse; Programs (PT); Programs [Publication Type]; Progress Review Group; Public Health; Pulse; Receptors, Antigen, T-Cell; Research; Research Personnel; Researchers; Sampling; T-Cell Epitopes; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Epitopes; T-Lymphocytes, Cytotoxic; TLR protein; TLR7; TLR7 protein, human; TLR7 receptor; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissue Growth; Toll-Like Receptor 7; Toll-like receptors; Transgenic Mice; Tumor Antigens; Tumor Immunity; Tumor-Associated Antigen; Tumors; Tumors of Neuroglia; Tumors, Central Nervous System; Vaccination; Veiled Cells; accessory cell; anticancer therapy; base; body system, allergic/immunologic; cancer therapy; clinical efficacy; design; designing; hTLR7; host response; human TLR7 protein; imaging; immune therapy; immunoresponse; in vivo; melanoma; melanoma-associated antigen; model organism; mouse model; neoplasia; neoplastic growth; ontogeny; organ system, allergic/immunologic; pre-clinical; preclinical; preclinical study; programs; public health medicine (field); response; stem; thymus derived lymphocyte; toll-like receptor 7, human; trafficking; tumor; tumor eradication; tumor-specific antigen; tumors in the brain; tumors in the central nervous system",CNS Anti-tumor immunity induced by dendritic cell vaccination and TLR agonists,,123396,ZRG1,Special Emphasis Panel,,4,234840,
7758374,R01,CA,5,,02/01/2010,01/31/2011,PA-04-157,5R01CA124332-04,,NCI:277400;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,PEDIATRICS,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"GAO, SHOU-JIANG ;",7678925;,5R01CA124332,04/01/2007,01/31/2012,"AIDS; AIDS associated cancer; AIDS related cancer; AIDS-Related Malignancy; AIDS-Related Malignant Neoplasm; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Activation, Gene; Antimorphic mutation; Antiretroviral Therapy, Highly Active; Blood Vessel Tumor; Butyrates; CSAIDS Binding Protein; CSBP; CSBP1; CSBP2; CSPB1; Cancers; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Clinical; Comparative Study; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Dermal; Developed Countries; Developed Nations; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7.2-; EFF; EXIP; Endocytosis; Endothelial Cells; Extracellular Signal-Regulated Kinases; Fibroblasts; Foreskin; Foreskin of penis; Gene Activation; Gene Expression; Generalized Growth; Genes, Viral; Germinoblastoma; Growth; HAART; HHV-8; HHV8; Highly Active Antiretroviral Therapy; Human; Human, General; Immunologic Deficiency Syndrome, Acquired; Industrialized Countries; Industrialized Nations; Infection; Inflammatory; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi's sarcoma of mouth; Kaposi's sarcoma of palate; Kaposi?s Sarcoma; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; MAP Kinase 14; MAP Kinase 8 Gene; MAP Kinase Mxi2; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MAPK14; MAPK14 gene; MAPK14 protein, human; MAPK8; MAPK8 gene; MAX-Interacting Protein 2; MEKs; Male Prepuce; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mitogen-Activated Protein Kinase p38Alpha; Mitogen-Activated Protein Kinases; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multicentric Angiofollicular Lymphoid Hyperplasia; Multicentric Castleman's Disease; Multiple Hemorrhagic Sarcoma; Mxi2; Neoplasms in Vascular Tissue; Nuclear; Oncogenic; Oral Kaposi's sarcoma; Organ; PRKM14; PRKM15; PRKM8; Palate Kaposi's Sarcoma; Pathogenesis; Pathway interactions; Patients; Phase; Prepuce; Preputium Penis; Preventive; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Receptor Protein; Regulation; Reticulolymphosarcoma; Role; SAPK1; SAPK2A; Sarcoma, Germinoblastic; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stress-Activated Protein Kinase 2A; Symptoms; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Trans-Acting Factors; Trans-Activators; Transactivators; Umbilical vein; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Viral; Viral Genes; Virion; Virus; Virus Particle; Virus-HHV8; Viruses, General; Visceral; anti-retroviral therapy, highly active; base; biological signal transduction; blood vessel neoplasm; cytokine; disease/disorder; effusion; expectation; experiment; experimental research; experimental study; gammaherpesvirus; human MAPK14 protein; human herpesvirus 8; inhibitor; inhibitor/antagonist; latent infection; lytic replication; lytic viral replication; lytic virus replication; malignancy; neoplasm/cancer; new therapeutic target; novel; ontogeny; oral kaposi sarcoma; oral ks; p38; p38 MAP Kinase; p38 MAPK; p38 MAPK Gene; p38 Mitogen Activated Protein Kinase; p38Alpha; p38Alpha EXIP; pathway; penis foreskin; programs; reactivation from latency; receptor; research study; social role; success; therapeutic target; trafficking; trans acting factor (genetic); tumor",Regulation of KSHV infection and replication by MAPK pathways,,124332,ZRG1,Special Emphasis Panel,,4,277400,
7760669,R01,CA,5,,02/01/2010,01/31/2011,PA-05-137,5R01CA124488-04,,NCI:225787;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,ANATOMY/CELL BIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"RAYCHAUDHURI, PRADIP ;",1869897;,5R01CA124488,04/25/2007,01/31/2012,"2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; API4; Abnormal Cell; Albumins; Amino Acid Sequence; Amino Acids; Animal growth regulators, transforming growth factors; Antibodies; Antioncogene Protein p53; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Assay; BIRC5; BUdR; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Bioassay; Biologic Assays; Biological Assay; Birth; Blotting, Western; Boxing; BrdU; Breeding; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CHIP assay; Cancers; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Nucleolus; Cell Proliferation; Cell Signaling; Cell division; Cells; Cellular Proliferation; Cellular Tumor Antigen P53; ChIP (chromatin immunoprecipitation); Complementary DNA; DENA; DNA, Complementary; Detection; Development; Diethylnitrosamine; E2F-1; E2F1; E2F1 gene; EPR-1; Enhancers; Ethanamine, N-ethyl-N-nitroso-; Exhibits; Extracellular Signal-Regulated Kinase Gene; Frequencies (time pattern); Frequency; Future; Gene Expression; Gene Targeting; Generalized Growth; Genotype; Goals; Growth; H-ras; H-ras Gene; H-ras Oncogene; HCC; HRAS; HRAS gene; HRAS1; Harvey Rat Sarcoma Viral Oncogene Homolog; Hepatic; Hepatic Cancer; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Human; Human, General; IAP4; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Liver; Liver Cells; Liver necrosis; Liver neoplasms; Lung; Lung Neoplasms; MAP Kinase Gene; MAPK; MAPK Signaling Pathway; MAPK Signaling Pathway Pathway; MMP-13; MMP-13 gene product; MMP-3; MMP13 gene product; MMP3; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase 3; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Murine; Mus; N,N-diethylnitrosamine; N-Nitrosodiethylamine; N-diethylnitrosamine; NDEA; Necrosis; Necrosis hepatocellular; Necrotic; Neoplasm Metastasis; Neoplasms, Hepatic; Nitrosodiethylamine; Oncogenic; Oncoprotein p53; Organ; PLK; PLK gene product; PLK1 protein, human; Parturition; Peptides; Phenemal; Phenobarbital; Phenobarbitone; Phenylbarbital; Phenylethylbarbituric Acid; Phosphoprotein P53; Phosphoprotein pp53; Plasmosome; Plk1 protein; Polo-Like Kinase; Polyomavirus macacae; Polyomavirus maccacae 1; Prealbumin; Primary carcinoma of the liver cells; Proalbumin; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promoters, Tumor; Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Structure, Primary; Protein TP53; Protein p53; Proteins; Pulmonary Neoplasms; RAS Gene; RASH1; RBBP3; RBP3; Recurrence; Recurrent; Reporting; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Rosa; Rose; STPK13 gene product; SV 40; SV 40 Virus; SV40; SV40 Virus; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Simian Vacuolating Virus 40; Simian virus 40; Stimulus; Stromelysin; Stromelysin 1; System; System, LOINC Axis 4; TP53; TRANSIN; Targetings, Gene; Technology; Testing; Time; Tissue Growth; Transforming Growth Factors; Transgenes; Transgenic Mice; Transgenic Organisms; Transin-1; Translational Research; Translational Research Enterprise; Translational Science; Transthyretin; Tumor Cell; Tumor Cell Migration; Tumor Growth Factors; Tumor Promoters; Tumor Protein p53; Tumor Suppressor Proteins; Tumor of the Lung; Uridine, 5-bromo-2'-deoxy-; Vacuolating Agent; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; aminoacid; angiogenesis; aurora B kinase; base; biological signal transduction; body system, hepatic; c myc; c-myc Genes; cDNA; cancer cell; cancer metastasis; chromatin immunoprecipitation; collagenase 3; collagenase activating protein; cyclin A2; design; designing; effective therapy; gene product; genetic promoter element; hepatic necrosis; hepatic neoplasia; hepatic neoplasm; human PLK1 protein; in vivo; inhibitor; inhibitor/antagonist; liver cancer; liver tumor; malignancy; malignant liver tumor; matrix metalloproteinase-13; mouse model; neoplasm/cancer; neoplastic cell; nucleolus; ontogeny; organ system, hepatic; p53 Antigen; p53 Tumor Suppressor; polo-like kinase 1; postnatal; prevent; preventing; procollagenase activator; programs; protein blotting; protein sequence; proteoglycanase; pulmonary; recombinase; resistant; response; stellate cell; survivin; transcription factor; transgenic; translation research enterprise; tumor; tumor suppressor; v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; vacuolating virus",Cell Penetrating Peptide Inhibitor of FoxM1 in Hepatocellular Carcinoma Treatment,,124488,TCB,Tumor Cell Biology Study Section,,4,225787,
7759228,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA124533-04,,NCI:240511;,2010,NATIONAL CANCER INSTITUTE,,UNIVERSITY PARK,UNITED STATES,VETERINARY SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"PETERS, JEFFREY M;",1924381;,5R01CA124533,03/01/2007,01/31/2012,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; APF-1; ATP-Dependent Proteolysis Factor 1; Actinic Rays; Apoptosis; Apoptosis Pathway; Apoptotic; Arachidonic Acid Cyclooxygenase; Attenuated; COX; COX inhibitor; Cancer Induction; Cancers; Carcinogen Tests; Carcinogenesis Tests; Carcinogenic Activity Tests; Carcinogenic Potency Tests; Carcinogenicity Tests; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cellular Proliferation; Chemicals; Chemoprevention; Colon; Coupled; Cyclo-Oxygenase; Cyclooxygenase; Cyclooxygenase Inhibitors; Data; Event; Exhibits; Exposure to; Fatty Acid Cyclo-Oxygenase; HMG-20; High Mobility Protein 20; Human; Human, General; Hydroperoxide Cyclase; Inhibition of Cell Proliferation; Inhibitors, Cyclo-Oxygenase; Intracellular Communication and Signaling; Knockout Mice; Laboratories; Lead; Ligands; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Melanoma and Non-Melanoma Skin Cancer; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Target; Murine; Mus; Negative Control of Cell Proliferation; Negative Regulation of Cell Proliferation; Null Mouse; PGH Synthase; PGH2 Synthetase; PPAR; PPAR-beta; PPARbeta; Pathway interactions; Pb element; Peroxisome Proliferator-Activated Receptors; Polyubiquitin Gene Product; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthase Inhibitors; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin H Synthase; Prostaglandin H2 Synthetase; Prostaglandin Synthase; Prostaglandin Synthase Inhibitors; Prostaglandin Synthesis Antagonists; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Regulation; Risk Factors; Role; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Skin Carcinogenesis; Staging; Sun/Ultra-Violet Rays; Testing; Transgenic Organisms; Translational Research; Translational Research Enterprise; Translational Science; Tumorigenicity; Tumorigenicity Tests; UV radiation; Ubiquitin; Ubiquitin C; Ultraviolet Rays; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Wild Type Mouse; biological signal transduction; cancer diagnosis; carcinogenesis; chemical carcinogen; chemical genetics; chemotherapy; cost; environmental chemical; heavy metal Pb; heavy metal lead; keratinocyte; keratinocyte differentiation; malignancy; neoplasm/cancer; novel; pathway; prevent; preventing; social role; transgenic; translation research enterprise; tumor; tumor growth; tumor initiation; ultraviolet light; ultraviolet radiation",Modulation of skin cancer by PPARBeta/delta,,124533,CE,Cancer Etiology Study Section,,4,240511,
7759645,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA124644-03,,NCI:334075;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PEDIATRICS,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"YAMASHIRO, DARRELL J;",1928559;,5R01CA124644,04/10/2008,01/31/2013,"0-11 years old; 21+ years old; APP Secretase; Adult; Amyloid Precursor Protein Secretase; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenesis, Pathologic; Angiogenesis, Pathological; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Architecture; Athymic Nude Mouse; Binding; Binding (Molecular Function); Blood Vessels; Cancers; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Child; Child Youth; Children (0-21); Clinical; Crossbreeding; Data; Development; Diagnosis; Disease; Disorder; Drugs; Endothelial Cells; Endothelium, Vascular; Engineering / Architecture; FLT1; FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Flt-1; Forecast of outcome; Generalized Growth; Genetic Models; Goals; Growth; Heterograft; Human; Human, Adult; Human, Child; Human, General; Hybridization, Genetic; Implant; In Vitro; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intracellular Communication and Signaling; KDR Tyrosine Kinase; Kidney; Kinase Insert Domain Receptor; Lead; Ligands; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Mice; Mice, Athymic; Mice, Nude; Models, Genetic; Molecular Interaction; Murine; Mus; NOTCH1 protein; Neovascularization Inhibitors; Neovascularization, Pathological; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Nude Mice; PGF; PGF gene; PLGF-2; Pathologic Neovascularization; Pathway interactions; Patients; Pb element; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; PlGF; Placental Growth Factor Gene; Prognosis; Proteins; Proto-Oncogene Protein flt; Receptor Protein; Receptor Tyrosine Kinase,Class V; Reporting; Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Staging; TAN-1 protein; Testing; Tissue Growth; Transplantation, Heterologous; Tube; Tumor Cell; Tumor-Derived; Tyrosine Protein Kinase FRT; Tyrosine Protein Kinase Receptor FLT; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary System, Kidney; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; VEGF Receptors; VEGFR; VEGFR-1; VEGFR-2; VEGFR1; VEGFR2; VEGFs; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Endothelium; Vascular Permeability Factor Receptor; Vegf; Work; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; adult human (21+); angiogenesis; antiangiogenic; biological signal transduction; children; cultured cell line; disease/disorder; drug/agent; experience; experiment; experimental research; experimental study; fms-Like Tyrosine Kinase; gene product; heavy metal Pb; heavy metal lead; in vivo Model; infancy; infantile; inhibitor; inhibitor/antagonist; knock-down; malignancy; neoplasm blood supply; neoplasm vascular supply; neoplasm/cancer; neoplastic cell; notch; notch protein; notch receptors; notch-1 protein; novel; ontogeny; outcome forecast; overexpression; pathway; pilot study; preclinical study; public health relevance; receptor; renal; research study; resistant; response; secretase; social role; tumor; tumor blood supply; tumor growth; tumor vascular supply; vascular; youngster",VEGF blockade and alternative angiogenic pathways in neuroblastoma,,124644,TPM,Tumor Progression and Metastasis Study Section,,3,334075,
7747931,R01,CA,5,,01/01/2010,12/31/2010,PA-07-070,5R01CA124687-02,,NCI:306063;,2010,NATIONAL CANCER INSTITUTE,,CHARLESTON,UNITED STATES,PATHOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"KAWAMORI, TOSHIHIKO ;",7185922;,5R01CA124687,01/01/2009,12/31/2013,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-; 4-Sphingenine; Aberrant crypt foci; Adenocarcinoma; Adenoma, Malignant; Adverse effects; Animal Model; Animal Models and Related Studies; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Azoxymethane; Beds; Blood Pressure, High; COX-2 protein; COX2; COX2 enzyme; COX2 inhibitor; Cancer Cause; Cancer Causing Agents; Cancer Etiology; Cancer Induction; Cancer Model; CancerModel; Cancers; Carcinogens; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; CellLine; Cells; Cellular Proliferation; Ceramide (lipids); Ceramides; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Clinical; Colon; Colon Cancer; Colon Carcinoma; Colon Neoplasms; Colonic Carcinoma; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Colorectal Cancer; Common Rat Strains; Coxibs; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; DIF; Data; Death; Development; Diazene, dimethyl-, 1-oxide; Dietary Factors; Dinoprostone; Down-Regulation; Down-Regulation (Physiology); Downregulation; Edg Receptors; Elements; Endothelial Cells; Enzymes; Epithelial Cells; Epoprostenol; Extracellular Signal-Regulated Kinase Gene; Fats; Fatty acid glycerol esters; Future; Gene Products, RNA; Generalized Growth; Goals; Growth; HT-29; HT-29 Cells; HT29 Cells; Human; Human, General; Hypertension; INFLM; In Vitro; Inflammation; Intestinal; Intestines; JNK; JNK1; JNK1A2; JNK21B1/2; Knock-out; Knockout; Lab Findings; Laboratories; Laboratory Finding; Lesion; Lipids; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK8; MAPK8 gene; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Mediating; Metastatic to; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Modeling; Murine; Mus; Oncogenesis; Oncogens; Organ System, Cardiovascular; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PGI2; PGX; PHS II; PRKM8; PTGS2; Pathogenesis; Pathway interactions; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevention strategy; Preventive strategy; Process; Production; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostacyclins; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin I(2); Prostaglandin I2; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostaglandins I; Prostanoids; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNAi; Rat; Rattus; Ribonucleic Acid; Rodent; Rodentia; Rodentias; Role; S1P Receptor; SAPK1; SPHK1 enzyme; Scheme; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Side; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptor; Staging; Stroke; System; System, LOINC Axis 4; TNF; TNF A; TNF gene; TNFSF2; Technology; Testing; Therapeutic; Tissue Growth; Toxic effect; Toxicities; Transgenic Mice; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Treatment Side Effects; Tumor Necrosis Factor Gene; Tumor Tissue; Tumor of the Colon; Umbilical vein; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Work; adenoma; anticarcinogenic; base; bowel; brain attack; cancer cell; cancer chemoprevention; cancer prevention; carcinogenesis; cardiovascular function; cerebral vascular accident; chemoprevention of cancer; circulatory system; colon carcinogenesis; cultured cell line; cyclo-oxygenase II; cyclooxygenase 2; cytokine; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; inhibitor; inhibitor/antagonist; insight; language translation; macrophage; malignancy; model organism; neoplasm/cancer; novel; ontogeny; overexpression; pathway; prostaglandin H synthase-2; prostaglandin X; public health relevance; response; screening; screenings; side effect; social role; sphingosine 1-phosphate; sphingosine kinase; sphingosine kinase-1; stroke; therapy adverse effect; translation research enterprise; treatment adverse effect; tumorigenesis",The Sphingolipid Pathway in Colon Cancer Chemoprevention," The most common preventable cancer is colorectal cancer. We found that sphingolipids play a pivotal role in colon cancer by regulating inflammation. In this project, we examine whether the sphingolipid pathway mediates development of colon cancer and we attempt to translate the bench results to bed-side clinical chemopreventive measures.",124687,CDP,Chemo/Dietary Prevention Study Section,,2,306063,
7760146,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA124709-03,,NCI:667730;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"MARIS, JOHN M;",1942322;,5R01CA124709,04/01/2008,01/31/2013,"0-11 years old; 21+ years old; Adult; African American; Afro American; Afroamerican; Allele Frequency; Alleles; Allelomorphs; Assay; BZS; Bioassay; Biologic Assays; Biological Assay; Biology; Black Populations; Black or African American; Cancer Cause; Cancer Etiology; Cancer Patient; Cancers; Candidate Disease Gene; Candidate Gene; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell Communication and Signaling; Cell Signaling; Characteristics; Child; Child Youth; Childhood; Childhood Cancers; Children (0-21); Children's Oncology Group; Clinical; Complex; Constitutional; Country; Custom; DNA; DNA Alteration; DNA Recombination; DNA Resequencing; DNA mutation; DNA recombination (naturally occurring); Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Diagnostic; Disease; Disease Outcome; Disorder; Dose; Evaluation; Event; Family; GUD; GWAS; Gene Alteration; Gene Frequency; Gene Mutation; Genes; Genes, p53; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Recombination; Genetic Susceptibility; Genetic mutation; Genome, Human; Genomics; Genotype; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Graph; H-ras; H-ras Gene; H-ras Oncogene; HRAS; HRAS gene; HRAS1; Hand; Haplotypes; Harvey Rat Sarcoma Viral Oncogene Homolog; Human; Human Genome; Human, Adult; Human, Child; Human, General; Inherited Predisposition; Inherited Susceptibility; Institution; Intracellular Communication and Signaling; KIAA0243; Lead; Linkage Disequilibrium Mapping; MHAM; MMAC1; Malignant Childhood Neoplasm; Malignant Childhood Tumor; Malignant Neoplasms; Malignant Pediatric Neoplasm; Malignant Pediatric Tumor; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; MeSH Descriptors Class 4; Modeling; Molecular; Mortality; Mortality Vital Statistics; Mutate; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Occidental; Oncogenesis; P53; PTEN; PTEN gene; PTEN1; Patients; Pb element; Penetrance; Phosphatase and Tensin Homolog; Polymorphism, Single Base; Population; Population Control; Predisposition gene; Principal Component Analyses; Principal Component Analysis; Qualifying; RAS Gene; RASH1; RB1; RB1 gene; Reagent; Recombination; Recombination, Genetic; Research; Research Design; Resequencing; SNP; SNPs; Sampling; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Staging; Stratification; Study Type; Survey Instrument; Surveys; Susceptibility Gene; Syndrome; TP53; TP53 gene; TRP53; TSC1; TSC1 gene; TSC2; TSC2 gene; Technology; Testing; Time; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Tsc1 [{C0694894}]; Tumor Biology; Tumor Protein p53 Gene; Validation; Variant; Variation; WAGR; WT1; WT1 gene; WT33; Wilms Tumor 1; adult human (21+); allelic frequency; base; biological signal transduction; biomarker; black American; cancer genomics; case control; children; clinical data repository; clinical data warehouse; cohort; data repository; density; design; designing; disease/disorder; drift mapping; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; geographic site; heavy metal Pb; heavy metal lead; insight; interest; language translation; malignancy; mutant; neoplasm/cancer; next generation; pediatric; pediatric cancer; pediatric neoplasm/cancer; predisposing gene; prognostic; public health relevance; relational database; response; sample collection; specimen collection; study design; translation research enterprise; tumor; tumor initiation; tumorigenesis; v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog; white race; whole genome association studies; whole genome association study; youngster",The Genetic Basis of Neuroblastoma Tumorigenesis,PUBLIC HEALTH RELEVANCE: Neuroblastoma is a common and lethal childhood cancer for which the genetic basis is poorly understood. Our genome-wide association study is designed to discover the most common variations in the human genome that lead to the development of neuroblastoma. These insights will lead to new molecular diagnostic assays and/or new treatments for this frequently devastating malignancy of young children.,124709,CG,Cancer Genetics Study Section,,3,667730,
7771627,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA124714-03,,NCI:210281;,2010,NATIONAL CANCER INSTITUTE,,TORONTO,CANADA,,,208469486,CA,ON,M5G 2M9,UNIVERSITY HEALTH NETWORK,"BROCK, KRISTY ;",8685177;,5R01CA124714,03/25/2008,01/31/2012,"Abdomen; Abdominal; Accounting; Active Follow-up; Anatomic; Anatomic Models; Anatomical Sciences; Anatomy; Aspiration, Respiratory; Assessment, Process; Biomechanics; Breathing; Cancer Radiotherapy; Cancer Treatment; Chemical Fractionation; Chest; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Complication; Development; Diagnostic Imaging; Documentation; Dose; Elements; Ensure; Environment; Evaluation; Exhalation; Exhaling; Expiration, Respiratory; FRACN; Fractionation; Fractionation Radiotherapy; Future; Gastrointestinal Tract, Pancreas; Goals; HOSP; Hand; Hepatic Cancer; Hospitals; Image; Imaging Procedures; Imaging Techniques; Imaging technology; Infrastructure; Inhalation; Inhaling; Inspiration, Respiratory; Institution; Investigation; Lead; Linear Models; Liver; Lung; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant neoplasm of liver; Medical Imaging, Positron Emission Tomography; Medical Imaging, Single Photon Emission Computed Tomography; Methods; Methods and Techniques; Methods, Other; Modality; Modeling; Models, Anatomic; Models, Anatomical; Morbidity; Morbidity - disease rate; Motion; Nature; Normal Tissue; Normal tissue morphology; Organ; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Pancreas; Pancreatic; Patients; Pb element; Physiologic; Physiological; Position; Positioning Attribute; Positron Emission Tomography Scan; Positron-Emission Tomography; Process; Process Assessment (Health Care); Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Radiation therapy; Radionuclide Tomography, Single-Photon Emission-Computed; Radiotherapeutics; Radiotherapy; Reporting; Research; Research Infrastructure; Respiratory System, Lung; SPECT; SPECT imaging; Scheme; Science of Anatomy; Scientist; Site; Slice; Solutions; Staging; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Technology; Testing; Thorace; Thoracic; Thorax; Time; Tomography, Emission-Computed, Single-Photon; Toxic effect; Toxicities; Translational Research; Translational Research Enterprise; Translational Science; Translations; Uncertainty; Work; anatomy; anticancer therapy; base; body system, hepatic; cancer therapy; clinical investigation; clinical practice; clinical significance; clinically significant; cone-beam computed tomography; design; designing; doubt; early experience; follow-up; heavy metal Pb; heavy metal lead; human tissue; image registration; imaging; imaging modality; improved; innovate; innovation; innovative; inspiration; irradiation; liver cancer; malignant liver tumor; novel; organ system, hepatic; programs; pulmonary; response; simulation; tool; translation research enterprise; treatment planning; treatment response; tumor",Dynamic multi-organ anatomical models for hypofractionated RT design and delivery,,124714,RTB,Radiation Therapeutics and Biology Study Section,,3,210281,
7760642,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA124758-03,,NCI:271900;,2010,NATIONAL CANCER INSTITUTE,,BATON ROUGE,UNITED STATES,BIOLOGY,06,075050765,US,LA,70803,LOUISIANA STATE UNIV A&M COL BATON ROUGE,"LEE, YONG-HWAN ;",7354504;,5R01CA124758,02/18/2008,01/31/2012,"Affinity; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogene Protein p53; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis Regulator; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biologic Characteristic; Biological Assay; Biological Characteristics; Body Tissues; Cancer Drug; Cancer Treatment; Cancer cell line; Cancerous; Cancers; Cell Death; Cells; Cellular Tumor Antigen P53; Cessation of life; Characteristic, Biologic; Characteristics; Chemicals; Chemotherapeutic Agents, Neoplastic Disease; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Combination Chemotherapy Regimen; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Death Rate; Development; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EC 2.7; FLR; Failure (biologic function); Fructose; Genetic; Glycolysis; HIF 1; HIF-1 protein; HIF1; HIF1 protein; History; Human; Human, General; Hydrolysis; Hypoxia; Hypoxic; Isoforms; Killings; Kinases; Kinetic; Kinetics; Lead; Levulose; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medication; Modeling; Models, Molecular; Modification; Molecular; Molecular Interaction; Molecular Models; Nucleic Acid Biochemistry, Molecular Modeling; Oncoprotein p53; Oxygen Deficiency; Pb element; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein P53; Phosphoprotein pp53; Phosphotransferases; Physiologic; Physiological; Property; Property, LOINC Axis 2; Protein Isoforms; Protein TP53; Protein p53; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Quimioterapia; Recording of previous events; Screening procedure; Structure; Structure-Activity Relationship; TP53; Testing; Time; Tissues; Transphosphorylases; Tumor Cell; Tumor Protein p53; Tumor Suppressor Proteins; Tumor-Specific Treatment Agents; Warburg Effect; anticancer agent; anticancer drug; anticancer therapy; base; cancer cell; cancer chemotherapy; cancer therapy; chemical structure function; clinical data repository; clinical data warehouse; cross reactivity; data repository; design; designing; drug discovery; drug/agent; failure; gene product; heavy metal Pb; heavy metal lead; hypoxia inducible factor 1; inhibitor; inhibitor/antagonist; malignancy; molecular modeling; necrocytosis; neoplasm/cancer; neoplastic cell; novel; p53 Antigen; p53 Tumor Suppressor; prevent; preventing; relational database; screening; screenings; small molecule; structure function relationship; tumor suppressor; virtual",PFKFB3-based development of a new cancer drug targeting the Warburg effect,,124758,DMP,Drug Discovery and Molecular Pharmacology Study Section,,3,271900,
7758385,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA124891-03,,NCI:391754;,2010,NATIONAL CANCER INSTITUTE,,BERKELEY,UNITED STATES,BIOLOGY,09,078576738,US,CA,947208202,UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB,"PARK, CATHERINE C;",7600178;,5R01CA124891,04/04/2008,12/31/2012,"3-D; 3-Dimensional; Animals; Apoptosis; Apoptosis Pathway; Basement membrane; Breast Cancer Cell; Cancer Patient; Cancer Radiotherapy; Cancer cell line; Cancer of Breast; Cancerous; Cancers; Carcinoma, Intraductal; Cell Communication and Signaling; Cell Culture Techniques; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cell-Extracellular Matrix; Cells; Clinical; DCIS; DNA Damage; DNA Injury; Data; Dose; Duct; Duct (organ) structure; Ductal Breast Carcinoma In Situ; Ductal Carcinoma In Situ; ECM; Electromagnetic Radiation, Ionizing; Epithelial Cells; Extracellular Matrix; Extracellular Matrix, Integrins; FADK; FAK; FAK1; Glycoprotein GP-2; Heterograft; Human; Human Breast Cancer Cell; Human, General; Integrin Inhibition; Integrins; Intracellular Communication and Signaling; Intraductal Carcinoma of the Breast; Ionizing radiation; Laminin; Letters; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Modeling; Non-Infiltrating Ductal Breast Adenocarcinoma; Non-Infiltrating Ductal Carcinoma of the Breast; Non-Infiltrating Intraductal Adenocarcinoma; Non-Infiltrating Intraductal Breast Adenocarcinoma; Non-Infiltrating Intraductal Carcinoma; Non-Invasive Ductal Breast Adenocarcinoma; Non-Invasive Ductal Carcinoma of the Breast; Non-Invasive Intraductal Breast Adenocarcinoma; Noninfiltrating Intraductal Carcinoma; Normal Tissue; Normal tissue morphology; PTK2; PTK2 gene; Patients; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Radiation therapy; Radiation-Ionizing Total; Radiotherapeutics; Radiotherapy; Receptor Protein; Recurrence; Recurrent; Research; Resistance; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Structure; Testing; Toxic effect; Toxicities; Transplantation, Heterologous; Treatment Efficacy; Xenograft; Xenograft procedure; Xenotransplantation; biological signal transduction; cancer cell; cancer progression; chemotherapy; in vivo; in vivo Model; irradiation; malignancy; malignant breast neoplasm; malignant phenotype; mammary; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; pp125FAK; prognostic; programs; radiation resistance; receptor; resistant; therapeutic efficacy; therapeutically effective; tumor; tumor progression",Manipulating b1 integrin to enhance radiation therapy for breast cancer,,124891,RTB,Radiation Therapeutics and Biology Study Section,,3,391754,
7758375,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA124952-03,,NCI:455093;,2010,NATIONAL CANCER INSTITUTE,,BIRMINGHAM,UNITED STATES,,06,006900526,US,AL,35205,SOUTHERN RESEARCH INSTITUTE,"SECRIST, JOHN A;",6329952;,5R01CA124952,03/12/2008,01/31/2013,"1,3 diazine; 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; 2',2'-DFDC; 2',2'-difluoro-2'-deoxycytidine; 2',2'-difluorodeoxycytidine; 2'-Deoxy-2-chloroadenosine; 2'-Deoxycytidine Kinase; 2'-deoxy-2'-difluorocytidine; 2'Deoxy-2',2'-Difluorocytidine; 2(1H)-Pyrimidinone, 4-amino-; 2,2 difluorodexoycytidine; 2-CDA; 2-Chloro-2'-deoxyadenosine; 2-Chlorodeoxyadenosine; 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine; 2-chloro-2'-fluoroarabino-2'-deoxyadenosine; 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine; 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine; 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; 21+ years old; 2CDA; ALL, Childhood; ARA-C Kinase; Adenosine, 2-chloro-2'-deoxy-; Adult; Animal Model; Animal Models and Related Studies; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Applications Grants; Area; Biochemical; Biochemical Pharmacology; Biological; Biological Models; C element; Cancer Drug; Cancer Treatment; Carbohydrates; Carbon; Carcinoma, Non-Small-Cell Lung; CdA; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cellular Membrane; Chemotherapeutic Agents, Neoplastic Disease; Childhood Acute Lymphocytic Leukemia; Childhood Acute Lymphogenous Leukemia; Childhood Acute Lymphoid Leukemia; Cl-F-ara-A; Cladribina; Cladribine; Clinical; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Clofarabine; Computer Simulation; Computerized Models; Criteria, Selection; Cytosine; DCK; DNA Polymerases; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Data; Deoxycytidine Kinase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Development; Difluorodeoxycytidine; Disease; Disorder; Drugs; EC 1.17.4.-; EC 2.7; EC 2.7.1.74; EC 2.7.7.7; Elements; Enzymes; Evaluation; F element; FDA approved; Fluorine; Goals; Grant Proposals; Grants, Applications; Half-Life; Half-Lifes; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic Cancer; Human; Human, Adult; Human, General; In Vitro; Intermediary Metabolism; Investigation; Investigators; Kinases; Knowledge; Laboratories; Lead; Learning; Leukemia, Lymphocytic, Acute, L1; Literature; Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Leukemia, Acute, L1; Lymphocytic Leukemia, L1; Lytotoxicity; METBL; Malignant Hematologic Neoplasm; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Pancreatic Neoplasm; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Mice; Mind; Model System; Models, Biologic; Models, Computer; Modification; Murine; Mus; NSCLC; NSCLC - Non-Small Cell Lung Cancer; NTP[{..}]deoxycytidine 5'-phosphotransferase; New Agents; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Normal Cell; Nucleic Acids; Nucleosides; O element; O2 element; Oxygen; Pancreas Cancer; Pancreatic Cancer; Pathway interactions; Pb element; Pediatric ALL; Pediatric Acute Lymphoblastic Leukemia; Pediatric Acute Lymphocytic Leukemia; Pediatric Acute Lymphogenous Leukemia; Pediatric Acute Lymphoid Leukemia; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Purines; Pyrimidine; Pyrimidine Nucleosides; Pyrimidines; Research; Research Personnel; Researchers; Ribonucleotide Reductase; S element; Selection Criteria; Series; Simulation, Computer based; Solid Neoplasm; Solid Tumor; Structural Protein; Structure; Study models; Sulfur; Thionucleosides; Toxic effect; Toxicities; Transphosphorylases; Tumor Cell; Tumor Cell Line; Tumor-Specific Treatment Agents; adult human (21+); analog; anticancer activity; anticancer agent; anticancer drug; anticancer therapy; base; cancer therapy; chemical stability; chlorodeoxyadenosine; clinical investigation; clinical test; compound-1; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cytotoxic; cytotoxicity; cytotoxicity test; dFdC; dFdCyd; design; designing; disease/disorder; drug discovery; drug/agent; enzyme substrate; gemcitabine; heavy metal Pb; heavy metal lead; improved; in silico; in vivo; infant ALL; meetings; model organism; necrocytosis; neoplastic cell; nonsmall cell lung cancer; novel; nucleoside analog; pathway; purine; research clinical testing; structural biology; tetrahydrofuran; triphosphate; tripolyphosphate; tumor; tumor xenograft; virtual simulation",4'-Substituted nucleoside analogs as anticancer drugs,,124952,DMP,Drug Discovery and Molecular Pharmacology Study Section,,3,455093,
7804572,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA125044-03,,NCI:317475;,2010,NATIONAL CANCER INSTITUTE,,MIAMI,UNITED STATES,SURGERY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"CAPOBIANCO, ANTHONY J;",1876831;,5R01CA125044,04/01/2008,01/31/2013,"Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Biological Models; Blood (Leukemia); Body Tissues; Cancerous; Carcinoma of the Uterine Cervix; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Growth and Maintenance; Cell Line, Tumor; Cell Locomotion; Cell Maintenance; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Transformation; Cervical Carcinoma; Cervix Uteri Carcinoma; Cervix carcinoma; Colon; Communication; Complex; Data; Disease; Disorder; Environment; Event; Exhibits; Family; Family member; Gene Expression; Gene Targeting; Genes; Goals; Human; Human, General; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Laboratories; Lead; Leukemias, General; Ligands; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Transgenic; Model System; Modeling; Models, Biologic; Motility; Motility, Cellular; Multiple Myeloma; Myeloma, Plasma-Cell; Neoplasms; Oncogenesis; Oncogenic; Pathway interactions; Pb element; Play; Process; Protein Family; Proteins; Receptor Protein; Reporting; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Squamous Cell Epithelioma; Squamous cell carcinoma; Subcellular Process; System; System, LOINC Axis 4; Targetings, Gene; Tissues; Transgenic Mice; Transmembrane Protein; Tumor Cell; Tumor Cell Line; Tumors; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; base; biological signal transduction; cell motility; cell transformation; disease/disorder; gene product; heavy metal Pb; heavy metal lead; insight; jagged-1; jagged1 protein; leukemia; member; meningioma; metaplastic cell transformation; model organism; mouse model; myeloma; myelomatosis; neoplasia; neoplastic; neoplastic cell; neoplastic growth; new therapeutic target; notch; notch protein; notch receptors; novel; pathway; prototype; public health relevance; receptor; social role; transformed cells; tumor; tumorigenesis",PDZ-dependent jagged 1 signaling in tumorigenesis,,125044,TME,Tumor Microenvironment Study Section,,3,317475,
7756651,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA125272-04,,NCI:235600;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"DANIEL, RENE ;",7038244;,5R01CA125272,04/01/2007,01/31/2012,"80 kDa Ku autoantigen; AIDS Virus; ASV; Antimorphic mutation; Apoptotic; Avian Sarcoma Viruses; Bears; CHIP assay; Catalytic DNA; Catalytic RNA; Cell Death; Cell Line; Cell Lines, Strains; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Assembly; Chromatin Modeling; Chromatin Structure; Closure by Ligation; Collaborations; Complex; Coon's Technic; Coon's Technique; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Integration; DNA Molecular Biology; DNA Repair; DNA Repair Pathway; DNA repair protein; DNA, Catalytic; DNA, Single-Stranded; DNA, Viral; DNA- PKcs protein; DNA-Activated Protein Kinase Catalytic Subunit; DNA-PK; DNA-PKcs; DNA-activated protein kinase; DNA-dependent protein kinase; DNA-dependent protein serine-threonine kinase; DNAPK; DNAzymes; DNPK1; Data; Deacetylase; Defect; Deoxyribonucleic Acid; Deoxyribozymes; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Enzymes; FGF-2; FGF2; FLR; Failure (biologic function); Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Flaps; Fluorescent Antibody Technic; Fluorescent Antibody Technique; Fluorescent Antinuclear Antibody Test; Friend Leukemia Virus; Friend Leukemia Virus, Conventional; Friend Murine Leukemia Virus; Friend Virus; G22P2; GFAC; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Genome; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF-2; HDAC; HDAC Proteins; HDAC-A; HDAC4; HDAC4 protein, human; HIV-1; HIV-I; HIV1; HYRC1; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Histone Deacetylase; Histone Deacetylase 4; Histone Deacetylase A; Histone Deacetylation; Histones; Human; Human immunodeficiency virus 1; Human, General; Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1; Immunodeficiency Virus Type 1, Human; Immunofluorescence; Immunofluorescence Immunologic; Immunofluorescence Technic; Immunofluorescence Technique; Immunologic, Immunofluorescence; Individual; Infection; Integrase; Intervention, Genetic; Investigators; Island Flaps; Kinetic; Kinetics; Ku Antigen, 80-Kd Subunit Gene; Ku autoantigen, 80 kDa; Ku80; Ku80 protein; Ku86 protein; Laboratories; Lead; Lesion; Life Cycle; Life Cycle Stages; Ligase; Ligation; Lymphocyte; Lymphocytic; Macromolecular Protein Complexes; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Biology; Molecular Biology, Gene Therapy; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Mouse Leukemia Viruses; Multiprotein Complexes; Murine leukemia virus; Mutation; NHEJ; Non-Homologous End Joining; Nonhomologous DNA End Joining; Normal Cell; Nucleosomes; Nucleotides; PRKDC; Pathway interactions; Pb element; Pennsylvania; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Prostate Epithelial Cell Growth Factor; Prostatropin; Proteins; RNA, Small Interfering; Reaction; Research Personnel; Researchers; Retroviral Vector; Retrovirus Vector; Ribozymes; Role; Rowson-Parr Virus; SCID protein; Single-Stranded DNA; Site; Small Interfering RNA; Surgical Flaps; Synthetases; Techniques; Testing; Therapy, DNA; Universities; Unscheduled DNA Synthesis; Ursidae; Ursidae Family; Viral; Virus; Viruses, General; Work; XRCC5; XRCC5 gene; XRCC7; XRCC7 protein; bFGF; base; chromatin immunoprecipitation; chromatin remodeling; conformation; conformational state; cultured cell line; experience; experiment; experimental research; experimental study; expression vector; failure; fluorescent antibody; gene product; gene therapy; genetic therapy; genome mutation; heavy metal Pb; heavy metal lead; histone deacetylase 4, human; human HDAC4 protein; human T cell leukemia virus III; human T lymphotropic virus III; human disease; life course; lymph cell; mutant; necrocytosis; novel; overexpression; p350; p460 protein; pathway; prevent; preventing; programs; reconstitute; reconstitution; repair; repaired; research study; response; retroviral transduction; scaffold; scaffolding; siRNA; social role; success; transfer of a gene; treatment effect; vector; viral DNA; virus DNA",Cellular co-factors in stable retroviral transduction,,125272,ZRG1,Special Emphasis Panel,,4,235600,
7755359,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA125387-03,,NCI:304917;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"XU, WEI ;",8436772;,5R01CA125387,04/01/2008,01/31/2013,"Arginine; Arginine, L-Isomer; BCEI; Biochemical; CARM1; Cancer of Breast; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Complex; D21S21; Development; E2F-1; E2F1; E2F1 gene; EC 2.1.1; EC 2.7; Engineering; Engineerings; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Gene Expression; Gene Targeting; Gene Transcription; Genes, p53; Genetic Transcription; Genomics; HPS2; Histone H3; Histones; Intracellular Communication and Signaling; Kinases; L-Arginine; Lead; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mediating; Methylation; Methyltransferase; Molecular; P53; Pathway interactions; Pb element; Phosphorylation; Phosphotransferases; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Methylation; Protein Phosphorylation; Quelling; RBBP3; RBP3; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Signaling; Receptors, Steroid; Regulation; Role; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Steroid Receptors; TFF1; TFF1 gene; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Therapeutic Estrogen; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Transphosphorylases; Tumor Protein p53 Gene; Up-Regulation; base; biological signal transduction; cancer progression; chromatin remodeling; coactivator-associated arginine methyltransferase 1; cultured cell line; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; in vivo; interest; kinase inhibitor; malignant breast neoplasm; methylase; mutant; neoplasm progression; neoplastic progression; pNR-2; pS2; pathway; research study; response; social role; tool; transmethylase; tumor progression",Transcriptional Regulation of Estrogen Receptor (ER) by CARM1,,125387,MCE,Molecular and Cellular Endocrinology Study Section,,3,304917,
7758306,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA125562-04,,NCI:288800;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"CHENG, EMILY H;",7043931;,5R01CA125562,03/01/2007,01/31/2012,"Address; Apoptosis; Apoptosis Pathway; Apoptotic; Autoregulation; B-Cell CLL/lymphoma 2; BAX; BAX gene; BCL-2 Protein; BCL2; BCL2 protein; BCL2-Associated X Protein Gene; BCL2L11; BCL2L11 gene; BCL2L4; BIM; BIMEL; BIML; BOD; BimMEL; Biochemical; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cells; Cessation of life; Complex; Cytotoxic Chemotherapy; Cytotoxic Therapy; Death; Development; Expression Profiling; Expression Signature; Family; Ferricytochrome c; Ferrocytochrome c; Genetic; Genetic Models; Goals; Homeostasis; ICE-like protease; Impairment; Individual; Intracellular Communication and Signaling; Killings; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Maps; Mediating; Mitochondria; Models, Genetic; Molecular Fingerprinting; Molecular Profiling; Organism; Pathway interactions; Physiological Homeostasis; Play; Programs (PT); Programs [Publication Type]; Protein Family; Proteins; Refractory; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signaling; Therapeutic; Translating; Translatings; VDAC2; VDAC2 gene; anticancer therapy; base; biological signal transduction; cancer cell; cancer therapy; caspase; cystein protease; cystein proteinase; cysteine endopeptidase; cytochrome c; gene product; genome-wide; language translation; living system; malignancy; member; mitochondrial; mitochondrial dysfunction; molecuar profile; molecular signature; necrocytosis; neoplasm/cancer; novel; pathway; prevent; preventing; programs; release factor; small molecule; social role; tumor",Apoptotic Network Integrated at the Mitochondrion,,125562,CAMP,Cancer Molecular Pathobiology Study Section,,4,288800,
7754685,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA125649-03,,NCI:318513;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,BIOCHEMISTRY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CARPENTER, GRAHAM F;",1878456;,5R01CA125649,04/01/2008,01/31/2013,"70-kD Heat-Shock Protein; Address; Antibodies; Binding; Binding (Molecular Function); Biochemistry; Biological; Biology; C225; CCND1 Protein; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Cycle Progression; Cell Nucleus; Cell Signaling; Cells; Cellular biology; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Clinical; Cyclin D1; Cytoplasm; Cytosol; Data; Dependence; Drugs; EGF; EGF gene; EGFR; ERBB Protein; ERBB1; Endocrine Gland Secretion; Endoplasmic Reticulum; Endosomes; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Erbitux; Ergastoplasm; G1/S-Specific Cyclin D1; GFAC; Generalized Growth; Golgi; Golgi Apparatus; Golgi Complex; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HER1; HSP; HSP 70; HSP70; Heat-Shock Proteins 70; Hormones; IMC-C225; Intracellular Communication and Signaling; Investigation; L-Tyrosine; Ligands; Limulus factor C; MAb C225; MOAB 225 Anti-EGFR (C225; Cetuximab); Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Medication; Membrane; MoAb C225; Molecular Interaction; Monoclonal Antibody C225; NLS Peptide; Nuclear; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Nuclear Receptors; Nuclear Translocation; Nucleus; PRAD1 Protein; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Proliferating; Proteins; Proto-Oncogene Proteins c-bcl-1; Reagent; Receptor Activation; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptosomes; Role; Route; Signal Transduction; Signal Transduction Systems; Signaling; Sorting - Cell Movement; TM Domain; TYR; Testing; Therapeutic Hormone; Tissue Growth; Transforming Growth Factor alpha Receptor; Transmembrane Domain; Transmembrane Region; Tyrosine; Tyrosine, L-isomer; URG; aberrant protein folding; abnormal protein folding; anticancer therapy; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; c-erbB-1; c-erbB-1 Protein; cancer therapy; cell biology; clinical relevance; clinically relevant; cyclin D; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; factor C; gene product; horseshoe crab factor C; hsp70 Family; malignancy; membrane structure; mutant; neoplasm/cancer; ontogeny; p97 ATPase; para-Tyrosine; pathologic protein folding; pathway; prevent; preventing; protein mis-folding; protein misfolding; proto-oncogene protein c-erbB-1; receptor; research study; response; social role; sorting; trafficking",Role of the Sec61 Translocon in EGF Receptor Trafficking and Signaling,"The focus of this grant is the EGF receptor, a protein that is a rational target for several  chemotherapeutic drugs that are approved for clinical use for different cancers. The application  proposes investigation of this receptor in response to its normal activator, a hormone-like growth  factor that stimulates cells to proliferate, as well as an antibody to the receptor that is one of the  clinically approved reagents for cancer treatment.",125649,TCB,Tumor Cell Biology Study Section,,3,318513,
7761287,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA125658-04,,NCI:285000;,2010,NATIONAL CANCER INSTITUTE,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ZHENG, YI ;",1902268;,5R01CA125658,02/10/2007,01/31/2012,"Active Oxygen; Animal Model; Animal Models and Related Studies; Antioncogene Protein p53; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Bone Marrow Transplant; Bone Marrow Transplantation; Burkitt Lymphoma; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Cancers; Cell Communication and Signaling; Cell Cycle Progression; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Tumor Antigen P53; Cellular biology; Cultured Cells; Defect; Development; Drug Kinetics; Effectiveness; Embryo; Embryonic; Family; Fibroblasts; Future; GTP Phosphohydrolases; GTPases; Generalized Growth; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome Stability; Germinoblastoma; Goals; Grafting, Bone Marrow; Growth; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hand; Hematopoietic; Human; Human, General; Individual; Intracellular Communication and Signaling; Isoforms; Knock-out; Knockout; Knockout Mice; Knowledge; Lead; Lymphocyte; Lymphocytic; Lymphoid; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lymphomagenesis; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Mother Cells; Murine; Mus; Mutation; Null Mouse; Oncogenesis; Oncoprotein p53; Oxygen Radicals; P53; Pathway interactions; Pb element; Pharmacokinetics; Phenotype; Phosphoprotein P53; Phosphoprotein pp53; Pro-Oxidants; Production; Progenitor Cells; Property; Property, LOINC Axis 2; Protein Isoforms; Protein TP53; Protein p53; Protocol; Protocols documentation; Reactive Oxygen Species; Research Specimen; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Specimen; Stability, Genomic; Stem cells; Structure; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Transducers; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Up-Regulation; Up-Regulation (Physiology); Upregulation; base; biological signal transduction; c myc; c-myc Genes; cancer cell; cell biology; cell growth; design; designing; functional status; gene function; genome mutation; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; loss of function; lymph cell; malignancy; member; model organism; mouse model; neoplasm/cancer; neoplastic cell; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; p53 Antigen; p53 Tumor Suppressor; pathway; prevent; preventing; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; screening; screenings; shRNA; short hairpin RNA; small hairpin RNA; small molecule; social role; stem; tumor; tumorigenesis; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog",Rac GTPases as Targets in Lymphomagenesis,,125658,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,4,285000,
7771754,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA125741-02,,NCI:351713;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"MANFREDI, JAMES J.;",1902874;,5R01CA125741,03/01/2009,01/31/2014,"API4; Address; Affect; Antioncogene Protein p53; Apoptosis; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; BIRC5; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Binding; Binding (Molecular Function); Biology; CDC25C; CDK; Cancers; Cdc25C protein; Cell Cycle; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Division Cycle; Cells; Cellular Tumor Antigen P53; Clinical; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cytokinesis; Cytoplasmic Division; DNA; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Injury; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; Data; Defect; Deoxyribonucleic Acid; Down-Regulation; Down-Regulation (Physiology); Downregulation; EPR-1; Ectopic Expression; Elements; Event; First Gap Phase; Forecast of outcome; Frequencies (time pattern); Frequency; G1 Phase; G1 period; G2/Mitotic-Specific Cyclin B1; Gap Phase 1; Gene Down-Regulation; Gene Targeting; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Human; Human, General; IAP4; In element; Indium; Individual; Lymphocytes, Null; M Phase; M phase (cell cycle); M-phase inducer phosphatase 3; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mitosis; Mitosis Stage; Mitotic; Molecular; Molecular Interaction; Mutation; Null Cells; Null Lymphocytes; Oncoprotein p53; Outcome; P53; Pathway interactions; Phosphoprotein P53; Phosphoprotein pp53; Play; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein TP53; Protein Turnover; Protein p53; Proteins; Regulation; Repression; Research; Role; Site; Stimulus; TP53; TP53 gene; TRP53; Targetings, Gene; Transcription Regulation; Transcription Repression; Transcriptional Control; Transcriptional Regulation; Transcriptional Repression; Treatment Efficacy; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressor Proteins; base; cdk Proteins; chemotherapeutic agent; cyclin B1; dual specificity phosphatase Cdc25C; experiment; experimental research; experimental study; gene product; gene repression; genome mutation; innovate; innovation; innovative; insight; malignancy; neoplasm/cancer; neoplastic cell; novel; outcome forecast; p53 Antigen; p53 Tumor Suppressor; pathway; prevent; preventing; protein degradation; public health relevance; repair; repaired; research study; response; social role; survivin; therapeutic efficacy; therapeutically effective; tumor; tumor suppressor; ubiquitin ligase",Role of p53 in cell cycle checkpoints," Project Narrative The p53 protein has clearly been implicated in playing an important role as a tumor suppressor in human cancer with mutation of the p53 gene being a common event in human tumors. p53 has a well-characterized role in mediating the cellular response to DNA damage. As many cancer chemotherapeutic agents exert effects by causing damage to genomic DNA, understanding the molecular basis for the involvement of p53 will identify new avenues for enhanced therapeutic efficacy.",125741,MONC,Molecular Oncogenesis Study Section,,2,351713,
7760632,R01,CA,5,,02/01/2010,01/31/2011,PAR-05-026,5R01CA126620-04,,NCI:319291;,2010,NATIONAL CANCER INSTITUTE,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"BUCHWALD, DEDRA S;",1875794;,5R01CA126620,04/25/2007,01/31/2012,"Advisory Committees; Age; Alaska; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; American Indian; American Indians; Baseline Surveys; Behavior; Cessation of Treatment; Characteristics; Chronic Disease; Chronic Illness; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Communication; Communication Programs; Communities; Community Participation; Country; Department of Health and Human Services; Department of Health and Human Services (U.S.); Disease; Disorder; Eating; Effectiveness of Interventions; Employee; Employee Strikes; Ethnic group; Evidence based practice; Federal Government; Flu vaccination; Food Intake; General Population; General Public; Goals; HHS; Habits; Health; Health Insurance; Health Promotion; Health Status; Indians, American; Indigenous Population; Individual; Influenza immunization; Influenza vaccination; Infrastructure; Insurance Benefits; Intervention; Intervention Strategies; Job Environment; Job Location; Job Place; Job Setting; Job Site; Level of Health; Life; Life Style; Lifestyle; MMG; Mammogram; Mammography; Measures; National Government; Native Alaskan; Native People; Native-Born; Outcome; Pap Test; Pap smear; Papanicolaou Smear; Papanicolaou Test; Participation, Community; Physical activity; Pilot Projects; Police; Policies; Population; Preventive; Process; Programs (PT); Programs [Publication Type]; Programs, Communication; Prophylactic vaccination against influenza; Randomized Controlled Trials; Recommendation; Recruitment Activity; Reporting; Research; Research Infrastructure; Salutogenesis; Sampling; Screening procedure; Services; Site; Smears, Cervical; Strikes; Strikes, Employee; Structure; Survey Instrument; Surveys; Surveys, Baseline; System; System, LOINC Axis 4; Task Forces; Testing; Time; Tobacco Cessation; Tobacco Use Cessation; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Vaginal Smears; Withholding Treatment; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; base; cervical/vaginal smear; chronic disease/disorder; chronic disorder; cost effectiveness; design; designing; disease/disorder; effect of intervention; efficacy testing; evidence base; falls; flu immunisation; health disparities; health disparity; improved; intervention effect; interventional strategy; new approaches; novel approaches; novel strategies; novel strategy; pilot study; programs; racial and ethnic; racial/ethnic; randomized controlled study; randomized trial; recruit; response; screening; screenings; sex; success; work environment; work setting",Randomized Trial of Workplace Interventions to Improve Health of Alaska Natives,,126620,ZRG1,Special Emphasis Panel,,4,319291,
7758325,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA126888-03,,NCI:281993;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"MUNSHI, HIDAYATULLAH G;",6687038;,5R01CA126888,04/01/2008,01/31/2013,"Adenocarcinoma Cell; Area; Biochemical; CCND1 Protein; CLG; CSBP1; CSBP2; CSPB1; Cancer Cause; Cancer Etiology; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Cessation of life; Clinical; Collagen; Collagen Type I; Cyclin D1; Data; Death; Deposit; Deposition; Desmoplastic; Desmoplastic Reaction; Development; Diagnosis; Disease; Disease-Free Survival; Disorder; Distant; Ductal Cell; Ductal Epithelial Cell; EC 2.7; ECM; EXIP; Esteroproteases; Event; Event-Free Survival; Extracellular Matrix; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinase Gene; Fibroblast Collagenase; Fibroblasts; Fibrosis; G1/S-Specific Cyclin D1; Gastrointestinal Tract, Pancreas; Generalized Growth; Goals; Growth; Human; Human, General; Integrin Binding; Integrins; Interstitial Collagenase; Intracellular Communication and Signaling; Kinases; Lead; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; MMP-1; MMP-14 gene product; MMP-1Fibroblast Collagenase; MMP-X1; MMP1; MMP14; MMP14 gene product; MMP14 protein, human; MT-MMP-1; MT1-MMP; MT1-matrix metalloproteinase; MTMMP1; Malignant Cell; Malignant Glandular Cell; Malignant Pancreatic Neoplasm; Malignant neoplasm of pancreas; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-1; Matrix Metalloproteinase-14; Mediating; Membrane-Inserted Matrix Metalloproteinase; Membrane-Type-1 Matrix Metalloproteinase; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mxi2; Neoplasm Metastasis; Outcome; PRAD1 Protein; PRKM14; PRKM15; Pancreas; Pancreas Cancer; Pancreas Ductal Adenocarcinoma; Pancreas Neoplasms; Pancreatic; Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Pancreatic Tumor; Pathogenesis; Patients; Pb element; Peptidases; Peptide Hydrolases; Phenotype; Phosphotransferases; Process; Progress Review Group; Proliferating; Proteases; Proteinases; Proteolytic Enzymes; Proto-Oncogene Proteins c-bcl-1; Reaction; Role; SAPK2A; Sampling; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Testing; Time; Tissue Growth; Transgenic Mice; Transgenic Model; Transphosphorylases; Tumor Cell Migration; Tumor of the Pancreas; Type 1 Collagen; Work; anticancer research; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; cancer cell; cancer metastasis; cancer research; cyclin D; design; designing; disease/disorder; experiment; experimental research; experimental study; feeding; heavy metal Pb; heavy metal lead; human MMP14 protein; improved; interstitial; mouse model; ontogeny; overexpression; p38; p38 MAPK Gene; p38Alpha; pancreatic neoplasm; public health relevance; research study; social role; treatment strategy; tumor; tumor growth",Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer Invasion,,126888,TME,Tumor Microenvironment Study Section,,3,281993,
7769835,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA126944-03,,NCI:287595;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"SHARMA, SHERVEN ;",1862230;,5R01CA126944,03/01/2008,01/31/2013,"ANXA5; ATGN; Address; Adoptive Transfer; Affect; Anchorin CII; Annexin A5 Protein; Annexin V; Antibodies; Antigen Presentation; Antigens; Antitumor Response; Apoptosis; Apoptosis Pathway; Area; Assay; B Cell Differentiation Factor I; B cell growth factor 2; B-Cell Growth Factor-II; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); Bioassay; Biologic Assays; Biological Assay; CBP-I; CCL21; CCL21 gene; CD183; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CKR-L2; CKb9; CMKAR3; COX-2 protein; COX2; COX2 enzyme; COX2 inhibitor; CSIF; CSIF-10; CTL; CXCR3; CXCR3 gene; Calphobindin I; Cancer Cause; Cancer Etiology; Cancer Model; Cancer Patient; Cancer Treatment; Cancer of Lung; CancerModel; Cancers; Carcinoma, Non-Small-Cell Lung; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cell-Mediated Lympholytic Cells; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Combined Modality Therapy; Coxibs; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Cytofluorometry, Flow; Cytokine Receptors; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytokines, Chemotactic; Cytolysis; Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Cytotoxic cell; Data; Death; Dendritic Cell Therapy; Dendritic Cells; Development; Diagnosis; Disease; Disorder; Documentation; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; EDF; Effectiveness; Effector Cell; Endonexin II; Environment; Eo-CSF; Eosinophil Differentiation Factor; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Forecast of outcome; Frequencies (time pattern); Frequency; Future; GPR9; Gene-Modified; Generalized Growth; Generations; Growth; Homologous Chemotactic Cytokines; IFN; IL-10; IL-5; IL-7; IL10; IL10A; IL5; IL7 Protein; IP10; IP10-R; ITX; IgA enhancing factor; Immune; Immune response; Immunity; Immuno-Chemotherapy; Immunochemotherapy; Immunologic, Immunochemical; Immunologically Directed Therapy; Immunologics; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunotherapy; Immunotherapy, Cancer, General; Infiltration; Injection of therapeutic agent; Injections; Intercrines; Interferons; Interleukin 10 Precursor; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin 7 Precursor; Interleukin-10; Interleukin-5; Interleukin-7; Investigation; Iodide, Propidium; K lymphocyte; Killings; Knock-out; Knockout; Knockout Mice; LYT3; Laboratories; Lead; Ligands; Lipocortin-V; Lung; Lung Neoplasms; Lymph node proper; Lymphocyte; Lymphocytes, Tumor-Infiltrating; Lymphocytic; Lymphoid; Lymphopoietin-1; Lysis; MADH7; MADH7 gene; MADH8; MGC34555; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mediating; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Mig-R; MigR; Modeling; Molecular; Monitor; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Myelogenous; Myeloid; Myeloid Cells; NIH; NK Cells; NSCLC; NSCLC - Non-Small Cell Lung Cancer; National Institutes of Health; National Institutes of Health (U.S.); Natural Killer Cells; Natural immunosuppression; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Null Mouse; PAP-I; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PP4; PTGS2; Pathway interactions; Patients; Pb element; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Peptides; Phenotype; Placental Anticoagulant Protein I; Placental Protein 4; Population; Pre-Clinical Model; Preclinical Models; Prognosis; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Propidium Diiodide; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protocol; Protocols documentation; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; Receptor Protein; Receptors, Cytokine; Recombinant Cytokines; Regimen; Regulatory T-Lymphocyte; Research; Resistance; Respiratory System, Lung; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Spleen; Role; SCYA21; SIS cytokines; SLC; SMAD7; Science of Statistics; Site; Specificity; Spleen; Staining method; Stainings; Stains; Statistics; Subcellular Process; Suppressor Cells; Suppressor-Effector T-Lymphocytes; T Suppressor Cell; T cell replacing factor; T-Cell Proliferation; T-Cell Replacing Factor; T-Cell Subsets; T-Cells; T-Cells, Suppressor-Effector; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte and NK-Cell; T-Lymphocyte and Natural Killer Cell; T-Lymphocyte, Regulatory; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Suppressor-Effector; T4 Cells; T4 Lymphocytes; TCA4; Testing; Therapeutic; Thromboplastin Inhibitor; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Translating; Translatings; Tumor Antigens; Tumor Burden; Tumor Load; Tumor of the Lung; Tumor-Associated Antigen; Tumor-Infiltrating Lymphocytes; United States; United States National Institutes of Health; VAC-Alpha; Vascular Anticoagulant-Alpha; Veiled Cells; Wild Type Mouse; annexin A5; anticancer therapy; base; cancer immunotherapy; cancer therapy; chemoattractant cytokine; chemokine; clinical applicability; clinical application; combat; combination therapy; combined modality treatment; combined treatment; cyclo-oxygenase II; cyclooxygenase 2; cytokine; disease/disorder; efficacy testing; experiment; experimental research; experimental study; flow cytophotometry; heavy metal Pb; heavy metal lead; helper T cell; host response; immune therapy; immunogen; immunogenicity; immunoresponse; immunosuppression; immunosuppressive; improved; in vivo; inhibitor; inhibitor/antagonist; language translation; lung cancer; lymph cell; lymph gland; lymph nodes; malignancy; multimodality therapy; neoplasm/cancer; new approaches; new therapeutics; next generation therapeutics; nonsmall cell lung cancer; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; ontogeny; outcome forecast; pMHC; pathway; programs; prostaglandin H synthase-2; pulmonary; receptor; research study; resistant; response; restoration; social role; statistics; suppressor T lymphocyte; thymus derived lymphocyte; tumor; tumor specificity; tumor-specific antigen",Novel Immune Pathways for Lung Cancer Therapy,,126944,CII,Cancer Immunopathology and Immunotherapy Study Section,,3,287595,
7761310,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA126968-03,,NCI:493253;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"ROSCOE, JOSEPH A;",6889253;,5R01CA126968,02/01/2008,01/31/2013,"1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-; 3-Hydroxydiazepam; Address; Adverse effects; Affect; After Care; After-Treatment; Aftercare; Agonist; Animal Welfare; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Anxiety; Apnea, Sleep; Arm; Beds; Behavior Therapy, Cognitive; Behavioral Therapy; Benzodiazepine Compounds; Benzodiazepine Receptor; Benzodiazepines; Bibliography; CCOP; Cancer Center; Cancer Patient; Cancer Radiotherapy; Cancer Survivor; Cancer Treatment; Cancer of Breast; Cancers; Cephalon brand of modafinil; Chronic Insomnia; Clinical; Cognitive Therapy; Combined Modality Therapy; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Community Clinical Oncology Program; Community Oncology; Compliance behavior; Controlled Clinical Trials, Randomized; Country; Coupled; Data; Depression; Diagnosis; Diaries; Diaries (PT); Diaries [Publication Type]; Ecological impact; Editorial Comment; Editorial Comment (PT); Enrollment; Environment; Environmental Impact; Equation; Equipment; Ethics Committees, Research; Exclusion Criteria; Fatigue; Female Breast Cancer; Female Breast Carcinoma; General Population; General Public; Health; Hydroxydiazepam; IACUC; IRBs; Impact, Environmental; Insomnia; Insomnia Disorder; Insomnia, Chronic; Insomnia, Primary; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Intervention Studies; Investigators; Lack of Energy; Link; Maintenance; Maintenances; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Carcinoma of the Female Breast; Measures; Mediating; Mental Depression; Methods; Methyloxazepam; Minority; Modafinil; Modeling; Monitoring, Sleep; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; N,N,6-trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate; Needs Assessment; Oncology Programs; Outcome; Oxydiazepam; PBO; Pain; Painful; Participant; Patient Compliance; Patient Cooperation; Patients; Placebos; Polysomnography; Population; Primary Insomnia; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Provigil; Psychotherapy, Cognitive; Published Comment; Publishing; QOL; Quality of life; Questionnaires; Radiation therapy; Radiotherapeutics; Radiotherapy; Randomized; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Receptors, Diazepam; Recruitment Activity; Regimen; Regression Analyses; Regression Analysis; Regression Diagnostics; Reporting; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; SUBGP; Sample Size; Sampling; Screening procedure; Selection Bias; Seminal; Severities; Sham Treatment; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Hypopnea; Sleep disturbances; Sleep-Disordered Breathing; Sleeplessness; Somnography; Statistical Regression; Study Section; Study Subject; Study Type; Subgroup; Survey Instrument; Surveys; Symptoms; Temazepam; Temezepam; Testing; Therapeutic; Therapy, Cognition; Time; Tradozone; Trazodone; Treatment Compliance; Treatment Efficacy; Treatment Side Effects; Universities; Upper arm; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; acronyms; anticancer therapy; benzhydrylsulfinylacetamide; cancer diagnosis; cancer therapy; chemotherapy; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; combination therapy; combined modality treatment; combined treatment; compliance cooperation; design; designing; diaries; enroll; experience; expiration; falls; human subject; hypnotic; improved; indexing; intervention effect; interventional strategy; irradiation; malignancy; malignant breast neoplasm; multimodality therapy; neoplasm/cancer; new approaches; novel approaches; novel strategies; novel strategy; patient adherence; polysomnographic; post intervention; programs; prospective; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; recruit; screening; screenings; sham therapy; side effect; sleep measurement; sleep polysomnography; sleep problem; social role; study design; therapeutic efficacy; therapeutically effective; therapy adverse effect; therapy compliance; therapy cooperation; treatment adverse effect; treatment strategy; vertebrata; zolpidem",CBT +/- Modafinil for Insomnia and Fatigue following Chemotherapy,,126968,PRDP,Psychosocial Risk and Disease Prevention Study Section,,3,493253,
7758344,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA126969-04,,NCI:311574;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SCHNOLL, ROBERT A;",6444916;,5R01CA126969,03/09/2007,01/31/2012,"Address; Adherence; Adherence (attribute); Affect; Affective; Area; Biochemical; Cancer Patient; Cancer of Lung; Cessation of Treatment; Cessation of smoking; Characteristics; Control Groups; Counseling; Cues; Data; Dependence, Nicotine; Development; Diagnosis; Disease; Disorder; Early Diagnosis; Enrollment; Event; Exhibits; Expectancy; Feedback; Future; General Population; General Public; Gestation; Guidelines; HOSP; Health; Health behavior change; Hospitalization; Intervention; Intervention Strategies; Intervention Studies; Investigation; Investigators; Lead; Life; Light; Link; Lung Cancer screening; Malignant Tumor of the Lung; Malignant neoplasm of lung; Married Persons; Matched Group; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nature; Newly Diagnosed; Nicotine Dependence; Nicotine Replacement Therapy; Observational Study; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Outcome; Patients; Pb element; Perception; Persons; Photoradiation; Physicians; Population; Pregnancy; Pregnant Women; Programs (PT); Programs [Publication Type]; Publishing; Pulmonary Cancer; Pulmonary malignant Neoplasm; Relative; Relative (related person); Research; Research Personnel; Researchers; Risk; Role; Screening for Lung Cancer; Screening procedure; Self Concept; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Smoking and Tobacco Use Cessation Interventions; Spouses; Time; Tobacco; Tobacco Consumption; Tobacco use; Translating; Translatings; Treatment Efficacy; Visit; Withholding Treatment; base; behavior change; cancer diagnosis; cease smoking; coping; design; designing; diet and exercise; disease diagnosis; disease/disorder; early detection; enroll; experience; health belief; health-related belief; heavy metal Pb; heavy metal lead; heuristics; improved; interventional strategy; language translation; lung cancer; lung cancer early detection; nicotine addiction; nicotine replacement; programs; prospective; response; risk perception; screening; screenings; smoking cessation; social role; therapeutic efficacy; therapeutically effective; tobacco control; uptake; willingness",Assessment of a Teachable Moment for Smoking Cessation,,126969,ZRG1,Special Emphasis Panel,,4,311574,
7761703,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA127152-04,,NCI:221178;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"DER, CHANNING J;",1864345;,5R01CA127152,04/11/2007,01/31/2012,"Behavior; Binding; Binding (Molecular Function); Biology; Cancer Genes; Cancer Treatment; Cancer-Promoting Gene; Carcinoma Cell; Carcinoma of the Large Bowel; Carcinoma of the Large Intestine; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; CellLine; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular biology; Clinical Evaluation; Clinical Testing; Colorectal Carcinomas; Complex; Development; EC 2.7; EC 2.7.2-; Endosomes; Epithelial Cells; Evaluation; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; Fibroblasts; Fluorescence; G-Protein Regulating Factors; GTP-Binding Protein Regulators; Gene Products, RNA; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Growth; H-ras; H-ras Gene; H-ras Oncogene; HRAS; HRAS gene; HRAS1; Harvey Rat Sarcoma Viral Oncogene Homolog; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Intracellular Communication and Signaling; Kinases; Large Intestine Carcinoma; Light; MAP Kinase Gene; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MEKs; Malignant; Malignant - descriptor; Malignant Cell; Malignant Epithelial Cell; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mediating; Methods and Techniques; Methods, Other; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinases; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Mutation; Nature; Normal Cell; Oncogenes; Oncogenesis; Oncogenic; Output; Pathway interactions; Phosphotransferases; Photoradiation; RAS Gene; RASH1; RGS Family Protein; RGS Protein (G-Protein Signaling); RGS Proteins; RNA; RNA, Non-Polyadenylated; Raf Kinase Inhibitor; Ras/Raf; Receptosomes; Regulating Factors, GTP-Binding Protein; Regulation; Regulators of G-Protein Signaling Proteins; Regulators, G-Protein Signaling; Ribonucleic Acid; Role; Scaffolding Protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small G-Proteins; Small GTPases; Structure; Subcellular Process; Techniques; Tissue Growth; Transforming Genes; Transphosphorylases; Tumor Cell; anticancer therapy; base; biological signal transduction; cancer cell; cancer therapy; cell biology; clinical test; cultured cell line; genome mutation; interest; melanoma; mutant; neoplastic; neoplastic cell; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; pathway; research clinical testing; scaffold; scaffolding; small molecule; social role; tumorigenesis; tumorigenic; v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog",Role of RGS proteins in Ras- and B-Raf--mediated transformation,,127152,CAMP,Cancer Molecular Pathobiology Study Section,,4,221178,
7759520,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA127162-03,,NCI:299776;,2010,NATIONAL CANCER INSTITUTE,,BUFFALO,UNITED STATES,,28,824771034,US,NY,14263,ROSWELL PARK CANCER INSTITUTE CORP,"DEMANT, PETER ;",7685952;,5R01CA127162,04/05/2008,01/31/2012,"Adhesion Molecule; Adhesions; Affect; Alleles; Allelomorphs; Animals; Antineoplastic Vaccine; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Blood Vessels; Blood granulocytic cell; Body Tissues; Bone Marrow; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; Cancer Causing Agents; Cancer Prognosis; Cancer Vaccines; Cancer of the Ovary; Cancers; Candidate Disease Gene; Candidate Gene; Carcinogens; Cell Adhesion Molecules; Cells; Characteristics; Chimera; Chimera organism; Clinical Research; Clinical Study; Colon or Rectum; Colorectal; Congenic Mice; Congenic Strain; Cytokines, Chemotactic; DNA analysis; Data; Distal; Effector Cell; Exercise; Exercise, Physical; Exhibits; Experimental Models; Experimental Models, Other; FLR; Failure (biologic function); Forecast of outcome; Frequencies (time pattern); Frequency; Gene Organization; Gene Structure; Gene Structure/Organization; GeneHomolog; Generations; Genes; Genetic; Genetic Polymorphism; Genome; Genomic Segment; Germ Lines; Goals; Granular Leukocytes; Granulocytic cell; Heterogeneity; Homolog; Homologous Chemotactic Cytokines; Homologous Gene; Homologue; Human; Human, General; ITX; Immune; Immune system; Immunologically Directed Therapy; Immunotherapy; In Vitro; Individual; Infection; Infiltration; Intercrines; International Union Against Cancer; Invaded; Killings; LYT3; Lead; Light; Lung Neoplasms; Lymphocyte; Lymphocytic; MHC Receptor; MMPs; Major Histocompatibility Complex Receptor; Malignant Melanoma; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Matrix Metalloproteinases; Measures; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Congenic; Mice, Transgenic; Models, Experimental; Molecular; Molecular Marker of Prognosis; Murine; Mus; Neoplasm Metastasis; Normal Tissue; Normal tissue morphology; OKT3 antigen; Oncogenesis; Oncogens; Outcome; Patient Selection; Patients; Pb element; Photoradiation; Polymorphism (Genetics); Polymorphism, Genetic; Probability; Process; Prognosis; Prognosis Marker; Prognostic Marker; Pulmonary Neoplasms; Receptors, Antigen, T-Cell; Regulation; Regulatory T-Lymphocyte; Reticuloendothelial System, Bone Marrow; Role; SIS cytokines; Secondary Neoplasm; Secondary Tumor; Solid Neoplasm; Solid Tumor; Staging; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T3 Antigens; T3 Complex; T3 molecule; T8 Cells; T8 Lymphocytes; TNM; TNM staging system; Testing; Thymus-Dependent Lymphocytes; Time; Tissues; Transgenic Mice; Tumor Antigens; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tumor Tissue; Tumor of the Lung; Tumor-Associated Antigen; UICC; Vaccines, Neoplasm; Vaccines, Tumor; Validation; Variant; Variation; abstracting; base; body system, allergic/immunologic; cancer metastasis; cell adhesion protein; chemoattractant cytokine; chemokine; congenic; failure; gene function; granulocyte; heavy metal Pb; heavy metal lead; immune therapy; improved; insight; interest; lymph cell; macrophage; malignancy; melanoma; migration; neoplasm/cancer; neoplastic cell; new approaches; new therapeutic target; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; outcome forecast; ovarian cancer; polymorphism; positional cloning; prevent; preventing; prognostic; response; reverse genetics; social role; thymus derived lymphocyte; trafficking; tumor; tumor growth; tumor-specific antigen; tumorigenesis; vaccine effectiveness; vascular",Host's Genes that Control Lymphocyte Infiltration of Tumors,,127162,TTT,"Transplantation, Tolerance, and Tumor Immunology",,3,299776,
7746494,R01,CA,5,,01/19/2010,12/31/2010,PA-07-070,5R01CA127219-03,,NCI:532744;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,NONE,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"SPITZ, MARGARET R;",1863468;,5R01CA127219,01/01/2008,12/31/2012,"Adopted; Affect; Age; Algorithms; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antihistamines; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Area; Articulation; Asbestos; Assay; Asthma; Base Excision Repairs; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biology; Body Tissues; Bronchial Asthma; COAD; COPD; Cancer Induction; Cancer of Lung; Cancers; Carcinoma, Non-Small-Cell Lung; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Division Cycle; Cellular Expansion; Cellular Growth; Characteristics; Chronic; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Complex; Computer Simulation; Computerized Models; DNA; DNA Base Excision Repair; DNA Damage Repair; DNA Molecular Biology; DNA Repair; DNA Repair Pathway; Data; Data Set; Dataset; Deoxyribonucleic Acid; Development; Dietary intake; Disease; Disorder; Drug usage; Dust; Emphysema; Enrollment; Environment; Epidemiology; Epidemiology, Personal Medical History; Ethnic Origin; Ethnicity; Ethnicity aspects; Family Cancer History; Frequencies (time pattern); Frequency; GFAC; Gender; Gene variant; Genes; Genes, p53; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genomics; Genotype; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Haplotypes; Hay fever; Hayfever; History; Host Defense; INFLM; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Intermediary Metabolism; International; Irritants; Joints; Learning, Machine; Letters; Life; Link; Literature; Logistic Regressions; Lung Parenchyma; Lung Tissue; Lymphocyte; Lymphocytic; METBL; Machine Learning; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Medical History; Medical Specialities; Metabolic Processes; Metabolism; Modeling; Models, Computer; Molecular; Molecular Biology; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Nature; Newly Diagnosed; Non-Hispanic; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Not Hispanic or Latino; Nucleotide Excision Repair; Occidental; Occupational Exposure; Oncogenesis; Outcome; Oxidative Stress; P53; Participant; Pathway interactions; Personal Medical History; Phenotype; Physicians; Play; Polymorphism (Genetics); Polymorphism, Genetic; Predisposition; Probability; Process; Progress Review Group; Proxy; Public Health; Publishing; Pulmonary Body System; Pulmonary Cancer; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pulmonary Organ System; Pulmonary malignant Neoplasm; Receiver Operating Characteristics; Recommendation; Recording of previous events; Recruitment Activity; Regression Analyses; Regression Analysis; Regression Diagnostics; Regressions, Logistic; Repairs, Base Excision; Research; Research Resources; Research Specimen; Resources; Respiratory System; Respiratory system (all sites); Respiratory tract structure; Rhinitis, Allergic, Seasonal; Risk; Risk Factors; Role; Seasonal Rhinitis; Simulation, Computer based; Smoke; Smoking; Smoking Behavior; Smoking History; Smoking Status; Specialties, Medical; Specialty; Specimen; Staging; Statistical Regression; Structure of parenchyma of lung; Susceptibility; TP53; TP53 gene; TRP53; Testing; Tissues; Tracts, Respiratory; Training; Tumor Protein p53 Gene; Unscheduled DNA Synthesis; Validation; Variant; Variation; Variation (Genetics); aggregation pathway; allelic variant; angiogenesis; base; cancer location; cancer risk; cancer site; carcinogenesis; case control; cell growth; chemical property; cigarette smoking; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; disease/disorder; drug use; enroll; gene interaction; genetic variant; in silico; kernel methods; lung cancer; lymph cell; malignancy; medical specialties; meetings; neoplasm/cancer; neoplastic; nonsmall cell lung cancer; novel; parent grant; pathway; pollenosis; polymorphism; public health medicine (field); public health relevance; recruit; repository; respiratory tract; response; smoke cigarette; social role; statistical learning; support vector machine; tool; tumorigenesis; virtual simulation; white race",Inflammation Genes and Lung Cancer Risk,"Public Health Relevance Statement Cigarette smoking results in inflammation in the respiratory tract and there is growing evidence that chronic inflammatory processes predispose to lung cancer. However, the molecular mechanisms underlying the causal nature of this association are unclear. We propose to conduct an in depth analysis of gene variants in the inflammatory pathway as susceptibility factors for lung cancer. This proposal builds upon an existing well annotated specimen repository. We will evaluate gene variants in a test set of lung cancer cases and matched controls and validate the findings in an independent dataset. Finally we will incorporate these findings into an extended risk prediction model for lung cancer.",127219,EPIC,Epidemiology of Cancer Study Section,,3,532744,
7766925,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA127240-03,,NCI:388025;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"SOLIT, DAVID B;",6270380;,5R01CA127240,03/10/2008,02/28/2013,"1-Phosphatidylinositol 3-Kinase; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Accounting; Adverse effects; Affect; Agents, Cytostatic; Akt protein; Apoptosis; Apoptosis Pathway; Apoptotic; B-raf-1; BRAF; BRAF gene; BZS; C-K-RAS; CCND1 Protein; Cancer Treatment; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Cycle Progression; Cell Death; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cellular Proliferation; Chimp; Chimpanzee; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Colon Neoplasms; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Comb animal structure; Combs; Cyclin D1; Cytostatic Drugs; Cytostatics; Cytotoxic Chemotherapy; Cytotoxic Therapy; Data; Dependence; Development; Dose-Limiting; Drugs; EC 2.7; EC 2.7.2-; EGFR; EGFR inhibition; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; ERBB2; ERBB2 gene; Enrollment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Event; Exanthem; Exanthema; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; G1/S-Specific Cyclin D1; GFAC; Generalized Growth; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HEK3; HER -2; HER-2; HER1; HER2; HER2/neu; Human; Human EGF Receptor 2 Gene; Human, General; Intracellular Communication and Signaling; Isoforms; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Kinases; MAP Kinase Activation Pathway; MAP Kinase Gene; MAP kinase; MAP-ERK Kinase; MAP3K1; MAP3K1 protein, human; MAPK; MAPK ERK Kinase Kinases; MAPK ERK Kinases; MAPK/ERK Kinase Kinase 1; MEK Kinase; MEK Kinase 1; MEK Kinases; MEK inhibition; MEKK1 Protein; MEKK1 protein, human; MEKKs; MEKs; MHAM; MMAC1; MSKCC; Malignant Cell; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Medication; Memorial Sloan-Kettering Cancer Center; Methods and Techniques; Methods, Other; Mill Hill-2 Viral Oncogene Homolog; Mitogen-Activated Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Modeling; Molecular; Mutation; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenesis; Oncogenic; PI-3 Kinase; PI-3K; PI-3K/AKT; PI3-Kinase; PI3CG; PI3K/AKT; PI3KGamma; PI3k; PIK3; PIK3CA; PIK3CA gene; PIK3CG; PIK3CG gene; PKB protein; PRAD1 Protein; PTEN; PTEN gene; PTEN1; PTK; PTK Receptors; Pan; Pan Genus; Pan Species; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinase, Catalytic Subunit Gene; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Play; Proliferating; Protein Isoforms; Protein Kinase B; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-1; PtdIns 3-Kinase; RAC-PK protein; RAF-1; RAF1; RAF1 gene; RAFB1; RASK2; RNA, Small Interfering; RTK; Rash; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Resistance; Role; Role of beta-arrestins in the activation and targeting of MAP kinases; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Rash; Small Interfering RNA; TKR1; Techniques; Testing; Tet; Tetanus Helper Peptide; Tissue Growth; Toxic effect; Toxicities; Transforming Growth Factor alpha Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Treatment Side Effects; Tumor Cell; Tumor of the Colon; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; abstracting; anticancer therapy; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-akt protein; c-bcl-1 Proteins; c-erbB-1; c-erbB-1 Protein; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer cell; cancer therapy; clinical applicability; clinical application; clinical investigation; cultured cell line; cyclin D; cytotoxic; drug/agent; enroll; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; gene product; genetic profiling; genome mutation; human MAP3K1 protein; hydroxyaryl protein kinase; in vivo; inhibitor; inhibitor/antagonist; malignancy; melanoma; mitogen-activated protein kinase kinase kinase 1, human; mutant; necrocytosis; neoplasm/cancer; neoplastic cell; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; p110-Alpha Gene; pathway; patient population; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; proto-oncogene protein c-erbB-1; rac protein kinase; receptor; related to A and C-protein; resistance mechanism; resistant; resistant mechanism; response; restoration; shRNA; short hairpin RNA; siRNA; side effect; small hairpin RNA; social role; therapy adverse effect; treatment adverse effect; tumor; tumor growth; tumorigenesis; tyrosyl protein kinase; upstream kinase; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; v-RAF-1 Murine Leukemia Viral Oncogene Homolog 1; v-raf Murine Sarcoma Viral Oncogene Homolog B1; vector",Targeting BRAF and MEK in tumors with BRAF and RAS mutations.,,127240,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,388025,
7759562,R01,CA,5,,02/01/2010,01/31/2011,PA-07-279,5R01CA127429-03,,NCI:262740;,2010,NATIONAL CANCER INSTITUTE,,GALVESTON,UNITED STATES,NEUROSCIENCES,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"VARGAS, GRACIE ;",7535186;,5R01CA127429,04/01/2008,01/31/2012,"Abscission; Address; Animal Model; Animal Models and Related Studies; Area; Biochemical; Biomedical Engineering; Biopsy; Body Tissues; Cancer Induction; Cancers; Cell Communication and Signaling; Cell Signaling; Cell Transformation, Neoplastic; Cell-Extracellular Matrix; Characteristics; Clinical; Collagen; Complex; Contrast Agent; Contrast Drugs; Contrast Media; Detection; Development; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; ECM; Early Diagnosis; Epithelial; Epithelial Neoplasms; Epithelium; Evaluation; Excision; Extirpation; Extracellular Matrix; Fluorescence; Fluorescence Agents; Fluorescence Spectroscopy; Fluorescent Agents; Fluorescent Dyes; Future; Generations; Goals; Histology; History; Human; Human, General; Image; Imaging Procedures; Imaging Techniques; Intracellular Communication and Signaling; Knowledge; Laboratories; Lesion; Lesion by Stage; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tumor; Malignant Tumor of the Mouth; Malignant neoplasm of mouth; Man (Taxonomy); Man, Modern; Maps; Medical; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Fluorescence, Multiphoton; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mouth Cancer; Neoplasms; Neoplastic Cell Transformation; Operation; Operative Procedures; Operative Surgical Procedures; Optical Methods; Optics; Oral Cancer; Oral Cavity Squamous Cell Carcinoma; Oral squamous cell carcinoma; Patients; Pre-Malignant; Premalignant; Process; Radiopaque Media; Recording of previous events; Recurrence; Recurrent; Removal; Research; SCC of the Mouth; SCC of the Oral Cavity; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Spectroscopy, Fluorescence; Squamous cell carcinoma of mouth; Staging; Stratified Squamous Epithelium; Structural Protein; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survival Rate; Technics, Imaging; Techniques; Testing; Texas; Tissues; Translations; Tumors; Universities; Visual; Work; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; biomarker; cancer progression; carcinogenesis; early detection; fluorescent dye/probe; imaging; improved; in vivo; malignancy; malignant mouth neoplasm; model organism; mouth squamous cell carcinoma; multidisciplinary; neoplasia; neoplasm progression; neoplasm/cancer; neoplastic; neoplastic growth; neoplastic progression; neoplastic transformation; novel; optic imaging; optical imaging; oral squamous carcinoma; precancerous; resection; second harmonic; spatiotemporal; spectroscopic imaging; surgery; tumor progression",Nonlinear Optical Staging of Epithelial Neoplasms,,127429,BMIT,Biomedical Imaging Technology Study Section,,3,262740,
7771761,R01,CA,5,,02/01/2010,01/31/2011,PA-08-121,5R01CA127446-02,,NCI:303173;,2010,NATIONAL CANCER INSTITUTE,,RICHMOND,UNITED STATES,NONE,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"LYON, DEBRA E;",1963721;,5R01CA127446,04/01/2009,01/31/2014,"21+ years old; Address; Adjuvant Chemotherapy; Adult; Age; Anxiety; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biological; C-reactive protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Cause; Cancer Etiology; Cancer Patient; Cancer Treatment; Cancer of Breast; Cancer, Oncology; Cancers; Categories; Cause of Death; Cephalic; Cessation of life; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Adjuvant; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Clinical Trials; Clinical Trials, Unspecified; Combination Chemotherapy Regimen; Complementary and alternative medicine; Control Groups; Cranial; Data; Death; Depressed mood; Depression; Diagnosis; Differentiation Factor, B-Cell; Distress; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Therapy, Adjuvant; Drugs; Electric Stimulation; Electrical Stimulation; Emotional Depression; Employment; FDA approved; Fatigue; Feasibility Studies; Funding; Goals; HPGF; Hepatocyte-Stimulating Factor; Home; Home environment; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Diseases; Immunological Diseases; Immunosuppressed Host; Infection; Inflammatory; Insomnia; Insomnia Disorder; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Interleukins; Intervention; Intervention Strategies; Lack of Energy; Lead; Link; MGI-2; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measures; Medication; Medicine; Mental Depression; Modality; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Movement; Myeloid Differentiation-Inducing Protein; NCCAM; NCI; NCI Organization; NIH; National Cancer Institute; National Center for Complementary and Alternative Medicine; National Institute of Nursing Research; National Institute on Aging; National Institutes of Health; National Institutes of Health (U.S.); Outcome; Pain; Painful; Participant; Patients; Pattern; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Pilot Projects; Plasmacytoma Growth Factor; Protein C; Proteins, specific or class, C-reactive; Psychological Stress; Public Health; QOL; Quality of life; Quimioterapia; Randomized; Randomized Clinical Trials; Research; Safety; Sampling; Science of Medicine; Self-Administered; Sleep disturbances; Sleeplessness; Source; Staging; Stress, Psychological; Symptoms; Symptoms of depression; TNF-alpha; Taxes; Testing; Time; Treatment Period; Trials, Randomized Clinical; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; United States; United States National Institutes of Health; Woman; adult human (21+); anticancer therapy; biobehavior; biobehavioral; body movement; breast cancer diagnosis; cancer chemotherapy; cancer therapy; chemotherapy; clinical investigation; cost; depressed; depressive; depressive symptoms; design; designing; drug/agent; falls; heavy metal Pb; heavy metal lead; immunosuppressed patient; inflammatory marker; innovate; innovation; innovative; interferon beta 2; interventional strategy; malignancy; malignant breast neoplasm; neoplasm/cancer; oncology; pilot study; prospective; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; sadness; symptom management; treatment as usual; treatment days; treatment duration; unspecified interleukin",Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer," Project Narrative The results of this study have the potential to reduce the discomforts of cancer chemotherapy in women receiving chemotherapy for breast cancer, thereby enhancing quality of life. Results from this study may also help to identify more clearly the biological causes for common, distressing symptoms.",127446,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,2,303173,
7758833,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA127475-04,,NCI:291650;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,PATHOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"GAJEWSKI, THOMAS F;",1906955;,5R01CA127475,04/01/2007,01/31/2012,"A Mouse; Adoptive Transfer; Apoptotic; Categories; Cell Communication and Signaling; Cell Signaling; Cells; Chemokine (C-C motif) Ligand 3; Clinical; Closure by Ligation; Cytokines, Chemotactic; Data; Defect; Disease Progression; Endothelial Cells; Environment; Enzymes; FLR; Failure (biologic function); Favorable Clinical Outcome; Future; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Goals; Homologous Chemotactic Cytokines; Human; Human, General; ITX; Immune; Immune response; Immunologically Directed Therapy; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunotherapy; In Vitro; Injection of therapeutic agent; Injections; Intercrines; Intracellular Communication and Signaling; Killings; L-Tryptophan; Levotryptophan; Ligands; Ligation; Link; MIP 1alpha; MIP-1 Alpha; MIP-1a; Malignant Melanoma; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Melanoma Cell; Melanoma Vaccine; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modeling; Murine; Mus; Natural immunosuppression; Neoplasm Metastasis; Outcome; Patients; Pattern; Phase; Phenotype; Play; Population; Pre-Clinical Model; Preclinical Models; Profilings, Gene Expression; Progressive Disease; Recruitment Activity; Regulatory T-Lymphocyte; Relative; Relative (related person); Resistance; Role; SIS cytokines; Secondary Neoplasm; Secondary Tumor; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Inducible Cytokine A3; Stem Cell Inhibitor; System; System, LOINC Axis 4; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; Testing; Thymus-Dependent Lymphocytes; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Tryptophan; Tumor Cell; Tumor Cell Biology; Tumor Cell Migration; Tumor Immunity; Vaccine Clinical Trial; Work; Xenograft Model; advanced disease; anergy; base; biological signal transduction; cancer metastasis; cancer progression; cell type; chemoattractant cytokine; chemokine; clinical applicability; clinical application; failure; host response; immune resistance; immune therapy; immunoresponse; immunosuppression; immunosuppressive; in vivo; melanoma; neoplasm progression; neoplastic cell; neoplastic progression; notch; notch protein; notch receptors; prevent; preventing; recruit; resistance mechanism; resistant; resistant mechanism; response; social role; thymus derived lymphocyte; trafficking; tumor; tumor progression",Countering immune resistance in the melanoma tumor microenvironment,,127475,ZRG1,Special Emphasis Panel,,4,291650,
7753903,R01,CA,5,,01/29/2010,11/30/2010,PA-07-072,5R01CA127493-02,,NCI:633291;,2010,NATIONAL CANCER INSTITUTE,,CLEVELAND,UNITED STATES,NONE,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"ZHANG, AMY Y;",8101709;,5R01CA127493,01/01/2009,11/30/2012,"Active Follow-up; Address; Adherence; Adherence (attribute); Adverse effects; After Care; After-Treatment; Aftercare; Arm; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biofeedback; Bladder; Bladder Control; Cancer Patient; Cancer Survivor; Cancer of Prostate; Cancers; Caring; Cessation of life; Clinical Trials; Clinical Trials, Unspecified; Computer Assisted; Conditioning Therapy; Cost Effective Analyses; Cost Effectiveness Analysis; Data; Death; Depressed mood; Diagnosis; Drug Formulations; Economic Burden; Educational process of instructing; Effectiveness of Interventions; Evaluation; Exercise; Exercise, Physical; Extravasation; FLR; Failure (biologic function); Feeling; Formulation; Formulations, Drug; Funding; Genital System, Male, Prostate; Goals; Group Meetings; Human Prostate; Human Prostate Gland; Incidence; Incontinence; Individual; Intervention; Intervention Strategies; Knowledge; Leakage; Learning; Life Style Modification; Longitudinal Studies; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Measures; Mediating; Medical; Medical Economics; Meetings, Group; Methods and Techniques; Methods, Other; Mission; Moods; Motivation; Muscle; Muscle Tissue; NCI; NCI Organization; National Cancer Institute; Newly Diagnosed; Nurses; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Outcome Study; Participant; Patients; Pelvic Floor Muscle; Personnel, Nursing; Phone; Physiologic; Physiological; Pilot Projects; Prevalence; Problem Solving; Productivity; Programs (PT); Programs [Publication Type]; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatectomy; Prostatic Cancer; Prostatic Gland; Prostatovesiculectomy; QOL; Quality of life; Quality-Adjusted Life Years; Radical Prostatectomy; Randomized; Recovery; Recruitment Activity; Reporting; Research; Self Care; Self Efficacy; Self Management; Self-Help Groups; Shame; Social support; Societies; Solutions; Sphincter; Spillage; Staging; Study, Outcome; Support Groups; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Teaching; Techniques; Telephone; Testing; Training; Treatment Side Effects; United States; Universities; Upper arm; Urethra; Urinary Incontinence; Urinary System, Bladder; Urodynamic; Urodynamics; base; behavior intervention; behavioral intervention; bladder continence; cancer care; cancer diagnosis; clinical investigation; combat; computer aided; computerized; cost; cost effectiveness; cost efficient analysis; depressed; effect of intervention; effective therapy; failure; feelings; follow-up; group intervention; improved; intervention effect; intervention program; interventional strategy; long-term study; malignancy; men; men's; micturition control; neoplasm/cancer; personal care; pilot study; problem solving therapy; programs; public health relevance; randomisation; randomization; randomly assigned; recruit; sadness; self help organization; side effect; skills; social support network; socioeconomic; socioeconomically; socioeconomics; standard care; surgery; therapy adverse effect; treatment adverse effect; treatment as usual; urethral; urinary; urinary bladder; urinary continence; urinary control; urination control",Improving Urinary Continence and Quality of Life in Prostate Cancer Patients," Project Narrative Despite a prevalence of urinary incontinence among posttreatment prostate cancer patients, men who suffer from urinary incontinence and its embarrassing symptoms, i.e., involuntary urinary leakage, have few options to combat this debilitating problem. But that may soon change. A research team at Case Western Reserve University is proposing a study that uses computer-assisted biofeedback along with group and telephone-based therapy to hone preexisting techniques - the Kegel exercises - to bring relief to men suffering from urinary incontinence, ultimately helping them, as the title of the study program says, ""STAY DRY.""",127493,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,2,633291,
7767011,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA127535-04,,NCI:360050;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"LIU, CHENG ;",8079227;,5R01CA127535,05/01/2007,01/31/2012,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; APP Secretase; Adriamycine; Affinity; Amyloid Precursor Protein Secretase; Antiproteases; Anzatax; Apaf-3 protein; Apoptosis; Apoptosis Pathway; Apoptotic; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; Asotax; Binding; Binding (Molecular Function); Blood Vessels; Breast Cancer Model; Bristaxol; CASP9 Protein; CATL; CTSL Protein; Cancer Model; Cancer Treatment; CancerModel; Caspase 9, Apoptosis-Related Cysteine Protease; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cathepsin B1; Cathepsin L; Cathepsins; Cathepsins B; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cell surface; Cell-Death Protease; Cell-Extracellular Matrix; Cells; Cessation of life; Collaborations; Collagen; Complex; Cysteine Endopeptidases; Cysteine Protease; Cysteine Proteinases; Cytoplasm; DIF; DOX; Death; Development; Diffuse; Dose; Doxorubicin; Doxorubicina; Drug Precursors; Drugs; EC 3.4.22.1; EC 3.4.22.15; ECM; Endopeptidase Inhibitors; Endothelial Cells; Environment; Esteroproteases; Extracellular Matrix; Extracellular Matrix, Integrins; GFAC; Gelatinase A; Gelatinase Neutrophil; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Hypoxia; Hypoxic; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; ICE-like protease; In Vitro; Integrins; Intervention; Intervention Strategies; Investigators; Lead; Leg; Lung; MMP-2; MMP2; Major Excreted Protein; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammalia; Mammals; Mammals, General; Mammals, Rodents; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-2; Mch6 protein; Mediating; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mitochondria; Molecular Interaction; Neoplasm Metastasis; Neoplasms; Normal Tissue; Normal tissue morphology; Oxygen Deficiency; Oxygen measurement, partial pressure, arterial; PEX; Paclitaxel; Paclitaxel (Taxol); Pathway interactions; Pb element; Penetration; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Plants; Plants, General; Play; Praxel; Pro-Drugs; Process; Prodrugs; Programs (PT); Programs [Publication Type]; Protease Antagonists; Protease Inhibitor; Proteases; Proteinase Inhibitors; Proteinases; Proteolytic Enzymes; Receptor Protein; Regulation; Reporting; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Rodent; Rodentia; Rodentias; Role; Secondary Neoplasm; Secondary Tumor; Solid Neoplasm; Solid Tumor; Specificity; Staging; Stromal Cells; Surface; TNF; TNF A; TNF gene; TNFSF2; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Thiol Protease; Toxic effect; Toxicities; Tumor Angiogenesis; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tumor Necrosis Factor Gene; Tumors; VEGFs; Vascular Endothelial Growth Factors; Vegf; angiogenesis; anticancer therapy; arterial pO2; asparaginyl endopeptidase; asparaginyl endopeptidase, lysosomal; asparaginylendopeptidase; base; cancer metastasis; cancer progression; cancer therapy; caspase; caspase-9; cell behavior; chemotherapeutic agent; cofactor; cystein protease; cystein proteinase; cysteine endopeptidase; density; design; designing; drug/agent; heavy metal Pb; heavy metal lead; improved; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; interventional strategy; legumain; lysosomal AEP; lysosomal asparaginyl endopeptidase; macrophage; mammary cancer model; mammary tumor model; mitochondrial; necrocytosis; neoplasia; neoplasm progression; neoplastic; neoplastic cell; neoplastic growth; neoplastic progression; oxygen tension; pathway; prevent; preventing; pro-caspase-9; procaspase-9; programs; pulmonary; receptor; resistant; social role; tumor; tumor growth; tumor progression; vascular",Cysteine Protease Network in Tumor Progression and Therapy,,127535,DMP,Drug Discovery and Molecular Pharmacology Study Section,,4,360050,
7756657,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA127574-03,,NCI:340300;,2010,NATIONAL CANCER INSTITUTE,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MATSUI, WILLIAM H;",6358170;,5R01CA127574,04/01/2008,01/31/2013,"AML - Acute Myeloid Leukemia; Biological; Blood Plasma Cell; Brill-Symmers Disease; Cancer stem cell; Cancer, Oncology; Cancers; Cells; Clinical; Clinical Treatment; Clonal Expansion; Data; Development; Disease; Disease Progression; Disease remission; Disorder; Drug resistance; Erinaceidae; FLR; Failure (biologic function); Follicle Center Lymphoma; Follicular Lymphoma; Follicular Non-Hodgkin's Lymphoma; Frequencies (time pattern); Frequency; General Prognostic Factor; Generalized Growth; Growth; Hedgehog (Hh) signal transduction pathway; Hedgehogs; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic Cancer; Human; Human, General; In Vitro; Lead; Leukemia, Myelocytic, Acute; Lymphoma, Follicular; Lymphoma, Giant Follicular; Lymphoma, Nodular; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Hematologic Neoplasm; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mature B-Cell; Mature B-Lymphocyte; Memory B Cell; Memory B-Lymphocyte; Mother Cells; Multiple Myeloma; Myeloblastic Leukemia, Acute; Myelogenous Leukemia, Acute; Myeloma, Plasma-Cell; Neoplastic Plasma Cell; Newly Diagnosed; Outcome; Pathway interactions; Patients; Pattern; Pb element; Plasma Cells; Plasmacytes; Population; Production; Progenitor Cells; Prognostic Factor; Prognostic/Survival Factor; Property; Property, LOINC Axis 2; RMSN; Recurrent disease; Regulation; Relapse; Relapsed Disease; Remission; Research Specimen; Resistance; Role; Signal Pathway; Specimen; Stem cells; Tissue Growth; Tumor Cell; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; cell type; clinical relevance; clinical significance; clinically relevant; clinically significant; disease/disorder; drug resistant; drug sensitivity; failure; heavy metal Pb; heavy metal lead; hedgehog signaling pathway; hh signaling pathway; in vivo; malignancy; myeloma; myelomatosis; neoplasm/cancer; neoplastic cell; notch; notch protein; notch receptors; novel; oncology; ontogeny; pathway; plasmocyte; progenitor; resistance to Drug; resistant; resistant to Drug; response; self-renewal; smoothened signaling pathway; social role; stem; stem cell fate; therapeutic target; trial regimen; trial treatment; tumor",Cancer Stem Cell Targeting in Multiple Myeloma,,127574,MONC,Molecular Oncogenesis Study Section,,3,340300,
7807094,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA127621-02,,NCI:431126;,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"ORNELLES, DAVID ARNOLD;",1868150;,5R01CA127621,04/20/2009,01/31/2014,"0-11 years old; 0-6 weeks old; ALL - Acute Lymphocytic Leukemia; AML1; AMLCR1; Aberrant Chromosome; Abnormalities, Chromosomal; Acute; Acute Lymphoid Leukemia; Acute leukemia; Adenoviridae; Adenoviridae Infections; Adenovirus Infections; Adenovirus Protein; Adenoviruses; Affect; Archives; Biology; Blood; Blood (Leukemia); Blood Precursor Cell; Blood Sample; Blood leukocyte; Blood specimen; Blood, Cord; CBFA2; CD34; CD34 gene; Cancers; Causality; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Characteristics; Child; Child Youth; Childhood; Childhood Leukemia; Children (0-21); Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Chromosomes; Clinical; Closure by Ligation; Comet Assay; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytology and Pathology; Cytopathology; DNA; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Repair; DNA Repair Inhibition; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Viral; Deoxyribonucleic Acid; Development; Disease Outcome; EC 2.7; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Gel, Pulsed-Field Gradient; Etiology; Event; Fractionation, Pulse Field; Frequencies (time pattern); Frequency; Gel Electrophoresis, Single-Cell; Genes; Genes, Viral; HPCA1; Hematopoietic stem cells; Human; Human, Child; Human, General; In Vitro; Individual; Infant; Infant, Newborn; Infection; Intracellular Communication and Signaling; Kinases; LEUKCL; Laboratories; Lead; Lesion; Leukemia, Lymphocytic, Acute; Leukemias, General; Leukemic Cell; Leukemogenesis/Lymphomagenesis; Leukocytes; Ligation; Lymphoblastic Leukemia, Acute; Lymphocyte; Lymphocytic; Lymphoid; Lymphoid Cell; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Marrow leukocyte; Measures; Mediating; Microorganisms, General; Mitotic Recombination; Molecular; Molecular Cytogenetics; Monitor; Mother Cells; Nature; Neonatal; Newborn Infant; Newborns; Nucleic Acids; Oncogenesis; One Step; One-Step dentin bonding system; PEBP2A2; PEBP2aB; PFGE; Pb element; Phosphorylation; Phosphotransferases; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Production; Progenitor Cells; Progenitor Cells, Hematopoietic; Protein Phosphorylation; Proteins; RUNX1; RUNX1 gene; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Running; Signal Transduction; Signal Transduction Systems; Signaling; Sister Chromatid Exchange; Stem cells; Testing; Transphosphorylases; Umbilical Cord Blood; Unscheduled DNA Synthesis; Viral Diseases; Viral Genes; Virus; Virus Diseases; Viruses, General; White Blood Cells; White Cell; Work; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; base; biological signal transduction; cancer cell; children; cohort; cultured cell line; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; fetal cord blood; fusion gene; gene product; heavy metal Pb; heavy metal lead; in utero; leukemia; leukemogenesis; lymph cell; malignancy; microorganism; neoplasm/cancer; newborn human (0-6 weeks); pathogen; pediatric; prenatal; public health relevance; repair; repaired; research study; response; stem; tumorigenesis; unborn; viral DNA; viral infection; virus DNA; virus infection; white blood cell; white blood corpuscle; youngster","Prenatal adenovirus infection, inhibition of DNA repair, and childhood leukemia"," RELEVANCE  These experiments will determine if a common and relatively innocuous virus, adenovirus, has the potential to contribute to acute childhood leukemia. These studies will advance our understanding of many aspects of adenovirus biology including the little known replication cycle of this virus in white blood cells and the frequency of adenovirus infections in the newborn. This work could provide the basis for early testing as well as help develop a simple treatment for the most common cancer of children.",127621,VIRA,Virology - A Study Section,,2,431126,
7763269,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA127725-03,,NCI:346525;,2010,NATIONAL CANCER INSTITUTE,,TAMPA,UNITED STATES,,11,139301956,US,FL,336129497,H. LEE MOFFITT CANCER CTR & RES INST,"CHELLAPPAN, SRIKUMAR P;",1872413;,5R01CA127725,04/17/2008,01/31/2013,"A549; ARB1; ARRB1; Accounting; Adhesions; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; Arrestin Beta 1; Arrestin Beta 1 Protein; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Vessels; Butanones; Cancer Causing Agents; Cancer of Lung; Cancers; Carcinogens; Carcinoma Cell; Carcinoma, Non-Small-Cell Lung; Cardiovascular Diseases; Cell Communication and Signaling; Cell Culture System; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Proliferation; Cessation of smoking; Colorectal Cancer; Development; Disease; Disorder; Dysfunction; Epithelial; Event; Exposure to; Functional disorder; G Protein-Coupled Receptor Signaling; GPCR Signaling; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Generalized Growth; Glia; Glial Cells; Growth; Immigrations; In Vitro; In-Migration; Intracellular Communication and Signaling; Kolliker's reticulum; Lead; Light; Lung; Lung Neoplasms; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mediating; Mesenchymal; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Molecular; Molecular Target; Murine; Mus; N'-nitrosonornicotine; N-nitrosonor-nicotine; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Neoplasm Metastasis; Neuroglia; Neuroglial Cells; Nicotine; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Non-neuronal cell; Nuclear Translocation; Nucleus; Oncogenesis; Oncogenic; Oncogens; Patients; Pb element; Photoradiation; Physiopathology; Play; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein-Tyrosine Kinases, src; Proteins; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-, (S)-; Receptor Protein; Relative; Relative (related person); Reporting; Resistance; Respiratory System, Lung; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Smoker; Smoking; System; System, LOINC Axis 4; Tissue Growth; Tobacco; Tobacco Consumption; Tobacco smoke; Tobacco use; Tobacco-Associated Carcinogen; Transcription Activation; Transcriptional Activation; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Tumor of the Lung; Tyrosine Phosphorylation; Up-Regulation; angiogenesis; arrestin 1; base; biological signal transduction; cancer cell; cancer metastasis; cancer progression; cardiovascular disorder; cease smoking; chemotherapeutic agent; cigarette smoking; combat; computerized data processing; cultured cell line; data processing; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; lung cancer; malignancy; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; nerve cement; nitrosonornicotine; nonsmall cell lung cancer; novel; ontogeny; pathophysiology; pulmonary; receptor; research study; resistant; response; signal processing; smoke cigarette; smoking cessation; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; tissue/cell culture; tumor; tumor growth; tumor progression; tumorigenesis; vascular",Role of Beta-arrestin-1 and Src in nAChR Signaling and Lung Caancer,,127725,TME,Tumor Microenvironment Study Section,,3,346525,
7759648,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA127927-03,,NCI:511095;,2010,NATIONAL CANCER INSTITUTE,,IRVINE,UNITED STATES,MISCELLANEOUS,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"SU, MIN-YING L;",2114424;,5R01CA127927,04/01/2008,01/31/2013,"(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4'[{..}]6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione; (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate; (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex; 14-Hydroxydaunomycin; 2,4-Dioxo-5-fluoropyrimidine; 2-Hydroxy-N,N,N-trimethylethanaminium; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; 3-D; 3-Dimensional; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 5-FU; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-Fluorouracil; 5-Fluracil; 5FU; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; Active Follow-up; Adriamycine; Anthracyclines; Anti-ERB-2; Anti-HER2/c-erbB2 Monoclonal Antibody; Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Anti-c-ERB-2; Anti-c-erbB2 Monoclonal Antibody; Anti-erbB-2; Anti-erbB2 Monoclonal Antibody; Anti-p185-HER2; Anzatax; Area; Arm; Asotax; Bevacizumab (rhuMAb VEGF); Biological Neural Networks; Blood Vessels; Breast; Breast Cancer Treatment; Bristaxol; CBDCA; CTX; CYCLO-cell; Campto; Cancer Patient; Cancer Staging; Cancer Treatment; Cancer of Breast; Cancers; Carboplatin; Carboplatino; Cardiac Toxicity; Cardiotoxicity; Carloxan; Characteristics; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Choline; Ciclofosfamida; Ciclofosfamide; Cicloxal; Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; Clafen; Claphene; Clinical; Clinical Research; Clinical Study; Cohort Studies; Combination Chemotherapy Regimen; Concurrent Studies; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytotoxic agent; Cytotoxic drug; Cytoxan; DOX; Data; Data Set; Dataset; Diagnostic Neoplasm Staging; Disease remission; Dose; Doxorubicin; Doxorubicina; ERBB2; ERBB2 gene; Endoxan; Endoxana; Enduxan; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Evaluation; FISH Technic; FISH Technique; FISH analysis; FLR; Failure (biologic function); Fibrosis; Fluorescent in Situ Hybridization; Fluoro Uracil; Fluorouracil; Fluoruracil; Fluouracil; Forecast of outcome; Fosfaseron; Future; General Prognostic Factor; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genoxal; Genuxal; Goals; Guidelines; HER -2; HER-2; HER2; HER2 Monoclonal Antibody; HER2/neu; Human EGF Receptor 2 Gene; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Imaging Procedures; Imaging Techniques; In Situ Hybridization, Fluorescence; In complete remission; Individual; Induction Therapy; Inflammatory; Institution; Irinotecan (CPT-11, Camptosar); Kinetic; Kinetics; Ledoxina; Lesion; Link; Literature; Locally Advanced Cancer; Locally Advanced Malignant Neoplasm; Logistic Regressions; MMG; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Ultrasonography; Mammogram; Mammography; Mammography, Ultrasonic; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Methods; Methods and Techniques; Methods, Other; Mitoxan; MoAb HER2; MoAb VEGF; Modeling; Monitor; Monoclonal Antibody Anti-VEGF; Morbidity; Morbidity - disease rate; Morphology; N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; NEOADJ; NMR Imaging; NMR Tomography; Neoadjuvant; Neoadjuvant Therapy; Neoadjuvant Treatment; Neoplasm Staging; Neosar; Nuclear Magnetic Resonance Imaging; One Step; One-Step dentin bonding system; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Paclitaxel; Paclitaxel (Taxol); Pathologic; Patients; Pattern; Praxel; Procytox; Prognosis; Prognostic Factor; Prognostic/Survival Factor; Protocol; Protocols documentation; Protocols, Treatment; Publishing; Quimioterapia; RGM; RMSN; ROC Analyses; ROC Analysis; ROC Curve; Radiation; Reaction; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Regimen; Regression Analyses; Regression Analysis; Regression Diagnostics; Regressions, Logistic; Relapse; Remission; Research Design; Residual Tumors; Resistance; RhuMAb VEGF; Role; Sendoxan; Statistical Regression; Study Type; Surgical; Surgical Interventions; Surgical Procedure; Survival Rate; Syklofosfamid; TKR1; Taxane Compound; Taxanes; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Taxotere; Technics, Imaging; Techniques; Testing; Texture; Therapeutic; Time; Toxic effect; Toxicities; Trastuzumab; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tumor Staging; Tumors, Residual; Ultrasonography, Breast; Ultrasonography, Mammary; Ultrasound Mammography; Upper arm; Zeugmatography; Zytoxan; [1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4'[{..}]6,7]indolizino[1,2-b]quinolin-9-yl ester; anticancer therapy; base; bevacizumab; biomarker; c-erb-2 Monoclonal Antibody; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; camptosar; cancer chemotherapy; cancer therapy; chemotherapy; cis-Diammine(cyclobutanedicarboxylato)platinum II; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); cohort; complete response; design; designing; docetaxel; docetaxol; effective therapy; failure; follow-up; imaging modality; improved; in vivo; irinotecan; malignancy; malignant breast neoplasm; mastitis; neoplasm/cancer; neural network; new therapeutics; next generation therapeutics; novel therapeutics; outcome forecast; platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); ray (radiation); residual disease; resistant; response; rhuMAb HER2; rhuMabVEGF; social role; soft tissue; standard care; study design; success; surgery; taxane; tumor; vascular",Prediction of Neoadjuvant Chemo Pathological Response Using MRI Markers,,127927,CBSS,Cancer Biomarkers Study Section,,3,511095,
7758766,R01,CA,5,,02/01/2010,01/31/2011,,5R01CA127990-04,,NCI:323063;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WAGNER, GERHARD ;",7784827;,5R01CA127990,04/01/2007,01/31/2012,"Address; Affinity; Amino Acids; Anti-Cancer Agents; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biologic Phenomena; Biological Assay; Biological Phenomena; C elegans; C-terminal; C.elegans; CREBBP-Associated Factor; Caenorhabditis elegans; Cancer Biology; Cancer Drug; Cancer cell line; Cancers; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Cellular biology; Chemotherapeutic Agents, Neoplastic Disease; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combining Site; Complex; DNA Binding Domain; DNA-Dependent RNA Polymerase II; Deletion Mutagenesis; Disease; Disorder; EC 2.3.1.-; Elements; Employee Strikes; Family; Fluorescence Polarization; GeneHomolog; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hand; Herpes Simplex; Herpes Simplex Infections; Herpes simplex disease; Herpesvirus hominis disease; Histone Acetylase PCAF; Homolog; Homologous Gene; Homologue; Human; Human, General; INFLM; In Vitro; Induction of Apoptosis; Inflammation; Inflammatory; Investigators; Knowledge; Ligand Binding Protein; Ligands; Link; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic syndrome; Methods; Molecular; Molecular Interaction; Mutation; NMR Spectroscopy; Nuclear; Nuclear Structure; Oncogene Products; Oncogene Proteins; Oncoproteins; P-CAF protein; P/CAF; P53; PCAF; Play; Polymerase; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Protein Binding; Protein Motifs, DNA-Binding; Proteins; Quelling; RNA Interference; RNA Polymerase B; RNA Polymerase II; RNA Silencing; RNA Silencings; RNAi; Reactive Site; Recruitment Activity; Regulatory Element; Regulatory Pathway; RegulatoryElement; Research; Research Personnel; Researchers; Role; Route; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Specificity; Spectroscopy, NMR; Sterols; Strikes; Strikes, Employee; Structure; TP53; TP53 gene; TRP53; Testing; Therapeutic; Trans-Activation (Genetics); Transactivation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Tumor Protein p53 Gene; Tumor-Specific Treatment Agents; VP 16; VP 16 (drug); VP16; Viral; Viral Diseases; Virus Diseases; Yeasts; adipogenesis; aminoacid; anticancer agent; anticancer drug; antitumor agent; base; cancer cell; cancer type; cell biology; cell growth; cofactor; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; genetic promoter element; genome mutation; improved; in vitro activity; in vivo; inhibitor; inhibitor/antagonist; insight; interest; lipid biosynthesis; lipid disorder; lipogenesis; malignancy; member; neoplasm/cancer; nuclear magnetic resonance spectroscopy; p300 acetyltransferase; p300-CREB-binding protein-associated factor; p300/CBP-Associated Factor; pCAF protein; programs; protein complex; recruit; research study; small molecule; social role; viral infection; virus infection",Transcriptional Activator/Coactivator Interactions,,127990,MSFC,Macromolecular Structure and Function C Study Section,,4,323063,
7755836,R01,CA,5,,02/01/2010,01/31/2011,PA-06-184,5R01CA128002-04,,NCI:277400;,2010,NATIONAL CANCER INSTITUTE,,CHARLESTON,UNITED STATES,PATHOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"DAMMAI, VINCENT R;",8138835;,5R01CA128002,04/01/2007,01/31/2012,"2 Dimensional Gel Electrophoresis; 2PP2A; Accounting; Address; Adenocarcinoma, Renal Cell; Anti-Oncogenes; Antioncogenes; Binding; Binding (Molecular Function); Biology; Body Fluids; Body Tissues; CXC-R4; CXCR-4; CXCR4; CXCR4 gene; Cancers; Carcinoma Cell; Carcinoma, Hypernephroid; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; Cell surface; Cell-Extracellular Matrix; CellLine; Cells; Cerebelloretinal Angiomatosis, Familial; Cerebroretinal Angiomatosis; Clear Cell; D2S201E; Defect; Dephosphin; Detection; Development; Diagnosis; Diagnostic; Dictyostelium discoideum dynamin A; Disease; Disorder; Distant; Dynamin; ECM; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Emerogenes; Endocytosis; Exhibits; Extracellular Matrix; FB22; FGF-1 receptor tyrosine kinase; FGFR-1; FGFR1; FGFR1 protein; FGFR1 tyrosine kinase; FLR; Failure (biologic function); Familial Cerebello-Retinal Angiomatosis; Fibroblast Growth Factor Receptor 1; Future; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grawitz Tumor; Growth; HLA-DR Associated Protein II; HM89; HSY3RR; Hippel Lindau syndrome; Hippel-Lindau Disease; Human; Human, General; Hypernephroma; I2PP2A; IGAAD; Immigrations; In Vitro; In-Migration; Inhibitor of GZMA-Activated DNase; Intracellular Communication and Signaling; Investigators; Kidney; Kidney Cancer; Kidney Carcinoma; Kidney Diseases; Kidney Neoplasms; Kidney Tubules, Proximal; Knowledge; LAP3; LCR1; LESTR; Lead; Lindau Disease; Link; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Molecular; Molecular Interaction; Murine; Mus; Mutation; NDPKA; NM23; NM23 Gene; NM23-H1; NM23H1; NME1; NME1 gene; NPY3R; NPYR; NPYRL; NPYY3R; Neoplasm Metastasis; Nephroid Carcinoma; Nephropathy; Nonmetastatic Protein 23 Gene; Nucleoside Diphosphate Kinase-A Gene; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; P53; PHAPII; Pathway interactions; Pb element; Peptides; Phenotype; Phosphatase 2A Inhibitor I2PP2A; Photometry/Spectrum Analysis, Mass; Process; Programs (PT); Programs [Publication Type]; Proliferating; Proteins; Proteomics; Protocol; Protocols documentation; Proximal Kidney Tubules; Publishing; Regulation; Renal Adenocarcinoma; Renal Cancer; Renal Cell Cancer; Renal Cell Carcinoma; Renal Cell Carcinoma, Stage Unspecified; Renal Disease; Renal Neoplasms; Renal Tumor; Renal carcinoma; Research Personnel; Researchers; Role; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Secondary Neoplasm; Secondary Tumor; Set protein; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; System; System, LOINC Axis 4; TAF-IBETA; TP53; TP53 gene; TRP53; Template Activating Factor I Beta; Testing; Therapeutic; Therapeutic Agents; Therapeutic Intervention; Tissue Growth; Tissues; Toxin; Transport Vesicles; Tumor Cell; Tumor Cell Migration; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor of the Kidney; Urinary System, Kidney; VEGFs; VHL gene mutation; VHL gene product; VHL mutation; VHL protein; Vascular Endothelial Growth Factors; Vegf; Von Hippel-Lindau Syndrome; Xenograft Model; adenocarcinoma of kidney; base; biological signal transduction; biomarker; cancer metastasis; cancer progression; cancer type; chemokine receptor; clinical applicability; clinical application; cultured cell line; disease/disorder; dynamin A; dynamin A, Dictyostelium discoideum; experiment; experimental research; experimental study; failure; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; insight; intervention therapy; kidney disorder; malignancy; membrane structure; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; oncosuppressor gene; ontogeny; pathway; prevent; preventing; programs; renal; renal disorder; renal proximal tubule; research study; shRNA; short hairpin RNA; small hairpin RNA; social role; therapeutic target; tumor; tumor growth; tumor progression; tumorigenesis; von Hippel Lindau disease gene mutation; von Hippel Lindau disease gene product; von Hippel Lindau disease mutation; von Hippel Lindau disease protein; von Hippel Lindau gene mutation; von Hippel Lindau gene product; von Hippel Lindau mutation; von Hippel Lindau protein; von Hippel-Lindau Disease",Cellular Factors Promoting Renal Cell Carcinoma,,128002,DMP,Drug Discovery and Molecular Pharmacology Study Section,,4,277400,
7755827,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA128931-03,,NCI:613475;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","VACHON, CELINE M;",1863027;,5R01CA128931,04/14/2008,01/31/2013,"Accounting; Active Follow-up; Age; Aquadiol; Atlas of Cancer Mortality in the United States; Atypia; Biology; Biopsy; Blood; Blood Sample; Blood specimen; Breast Cancer Risk Factor; Breast Neoplasms; Breast Tumors; Cancer Maps; Cancer of Breast; Cancers; Candidate Disease Gene; Candidate Gene; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cell Communication and Signaling; Cell Signaling; Chromosome 2; Chromosome 5; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 5; Clinic; Cohort Studies; Common Rat Strains; Concurrent Studies; Country; DNA; DNA Resequencing; Deoxyribonucleic Acid; Dimenformon; Diogyn; Diogynets; EC 2.7; Epidemiology, Molecular; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Family; Family Study; Female; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Variation; Genetic defect; Genetics, Gene Mapping; Genotype; Goals; Health; Histology; Intracellular Communication and Signaling; Kinases; Length of Life; Linkage (Genetics); Linkage Analysis; Linkage Disequilibrium; Linkage Disequilibriums; Linkage Mapping; Lod Score; Longevity; MMG; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Rats; Mammary Cancer; Mammary Neoplasms; Mammogram; Mammographic Density; Mammography; Maps; Molecular Epidemiology; Mutation; Ovocyclin; Ovocylin; Pathway interactions; Patients; Phosphotransferases; Polymorphism, Single Base; Population; Population Study; Prevention strategy; Preventive strategy; Progynon; Proteins; Publishing; Racial Segregation; Rat; Rattus; Resequencing; Residual; Residual state; Reticuloendothelial System, Blood; Risk; Role; SNP; SNPs; Sampling; Scanning; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Stratification; Study of epidemiology; Testing; Therapeutic Estradiol; Translating; Translatings; Transphosphorylases; Twin Studies; Variant; Variation; Variation (Genetics); Woman; Work; allelic variant; association test; base; biological signal transduction; breast density; cancer risk; cohort; cost; density; epidemiology study; family based linkage study; follow-up; gene product; genetic association; genetic linkage; genetic linkage analyses; genetic linkage analysis; genetic mapping; genome mutation; improved; interest; language translation; life span; lifespan; linkage analyses; malignancy; malignant breast neoplasm; mammary tumor; member; neoplasm/cancer; pathway; prospective; public health relevance; segregation; social role",Identifying Genes for Mammographic Breast Density,"PUBLIC HEALTH RELEVANCE: Genes for breast density may predispose women to high density across the lifespan, translating to increased breast cancer risk. Identifying and understanding these genes will inform our limited biology of the breast density and breast cancer association as well as improve risk prediction and stratification enabling identification of patients who will benefit from early prevention strategies.",128931,EPIC,Epidemiology of Cancer Study Section,,3,613475,
7760677,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129036-03,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MISCELLANEOUS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"FAN, ZHEN ;",6495885;,5R01CA129036,04/02/2008,01/31/2013,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adaptor Protein; Adaptor Signaling Protein; Adverse effects; Anemia; Anti-Cancer Agents; Anti-ERB-2; Anti-HER2/c-erbB2 Monoclonal Antibody; Anti-Tumor Agents; Anti-Tumor Drugs; Anti-c-ERB-2; Anti-c-erbB2 Monoclonal Antibody; Anti-erbB-2; Anti-erbB2 Monoclonal Antibody; Anti-p185-HER2; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Autocrine Systems; Binding; Binding (Molecular Function); Binding Sites; Blood erythrocyte; Blood normocyte; Body Tissues; Bone Marrow; Breast Cancer Cell; Breast Neoplasms; Breast Tumors; Cancer Cell Growth; Cancer Drug; Cancer Patient; Cancer cell line; Cancer of Breast; Cancers; Cardiac; Case Study; Cell Communication and Signaling; Cell Protection; Cell Signaling; Cell Surface Receptors; Cells; Cessation of life; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Colony-Stimulating Factor 2 Alpha; Combining Site; Conditioned Culture Media; Conditioned Medium; Culture Media, Conditioned; Cytokine Receptors; Cytoprotection; Death; Docking; Drugs; EC 2.7; EC 2.7.2-; ECSF; EGFR; EPO-R; ERBB Protein; ERBB1; Eosinophil-Mast Cell Growth-Factor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epoetin; Erythrocyte Burst-Promoting Factor; Erythrocytes; Erythrocytic; Erythroid Precursor Cells; Erythroid Progenitor Cells; Erythropoiesis; Erythropoietic Stem Cells; Erythropoietin; Erythropoietin Receptor; Extracellular Signal-Regulated Kinases; Family; Fatigue; Frequencies (time pattern); Frequency; Genentech brand of trastuzumab; Goals; HER1; HER2 Monoclonal Antibody; Hematopoietic Cytokine; Herceptin; Heterograft; Hoffman-La Roche brand of trastuzumab; Homodimerization; Human; Human Breast Cancer Cell; Human, General; IL-3; IL-3(H); IL3 Protein; Iatrogenic Cancer; Interleukin 3 (Colony-Stimulating Factor, Multiple); Interleukin 3 Precursor; Interleukin-3; Intracellular Communication and Signaling; Investigation; JAK-2; JAK2; JAK2 protein; Janus kinase 2; Kidney; Kinases; Knowledge; L-Tyrosine; Laboratories; Lack of Energy; Link; MAP Kinase Kinases; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MAPK Kinases; MAPKKs; MCGF; MEKs; MULTI-CSF; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mast-Cell Colony-Stimulating Factor; Mast-Cell Growth Factor; Mediating; Medication; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; MoAb HER2; Moab, Clinical Treatment; Molecular Interaction; Monoclonal Antibodies; Multilineage-Colony-Stimulating Factor; Multipotential Colony-Stimulating Factor; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; P-CSF; P-Cell Stimulating Factor; PI-3 Kinase; PI-3K; PI3-Kinase; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphotransferases; Play; Production; Progenitor Cells, Erythropoietic; Protein Phosphorylation; PtdIns 3-Kinase; Reactive Site; Receptor Activation; Receptor Cell; Receptor Protein; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Cell Surface; Receptors, Cytokine; Receptors, Epidermal Growth Factor-Urogastrone; Recombinants; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relapse; Renal Tissue; Research; Research Specimen; Resistance; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Erythrocytes; Retinal; Roche brand of trastuzumab; Role; SH2 Domains; STAT protein; Signal Pathway; Signal Transducer and Activator of Transcription; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Stem Cells, Erythroid; TYR; Testing; Therapeutic; Therapy Related Malignant Neoplasm; Therapy Related Malignant Tumor; Therapy-Associated Cancers; Therapy-Related Cancer; Tissues; Transforming Growth Factor alpha Receptor; Transphosphorylases; Transplantation, Heterologous; Trastuzumab; Treatment Side Effects; Treatment-Associated Cancer; Treatment-Related Cancer; Tumor-Specific Treatment Agents; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine; Tyrosine, L-isomer; Tyrosine-Protein Kinase JAK2; Urinary System, Kidney; Validation; Xenograft; Xenograft procedure; Xenotransplantation; anticancer agent; anticancer drug; autocrine; base; biological signal transduction; blood corpuscles; c-erb-2 Monoclonal Antibody; c-erbB-1; c-erbB-1 Protein; cancer cell; case report; chemotherapy; clinical relevance; clinically relevant; cytokine; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; erythrocyte colony stimulating factor; exposed human population; hematopoietic growth factor; hematopoietin; high risk; human exposure; malignancy; malignant breast neoplasm; mammary tumor; member; neoplasm/cancer; neuronal; novel; overexpression; para-Tyrosine; paracrine; prevent; preventing; proto-oncogene protein c-erbB-1; public health relevance; receptor; receptor expression; recombinant human erythropoietin; renal; resistant; response; rhuMAb HER2; side effect; social role; src Homology Region 2 Domain; therapy adverse effect; treatment adverse effect; tumor",Mechanisms of tumor resistance to anti-HER/ErbB therapeutics,,129036,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,319550,
7759528,R01,CA,5,,02/01/2010,01/31/2011,PA-07-295,5R01CA129091-04,,NCI:625767;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,OTHER HEALTH PROFESSIONS,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"HOUSTON, THOMAS K;",6987483;,5R01CA129091,04/11/2008,01/31/2013,"2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; Active Follow-up; Adoption; Arts; Awareness; Awarenesses; Behavior; Care, Health; Caring; Cause of Death; Cessation Research; Cessation of smoking; Characteristics; Clinical; Communication; Communities; Complex; Compliance behavior; Control Groups; Cotinine; Counseling; Data; Data Collection; Delivery of Health Care; Dental; Dimensions; Drug Therapy; Enrollment; Feedback; Funding; Goals; Health Care Research; Health Sciences, Allied and Health Services Delivery; Health Services; Health Services Evaluation; Health Services Research; Healthcare; Healthcare Delivery; Healthcare Research; Information Technology; Institutes; Internet; Intervention; Intervention Strategies; Interview; Link; Measures; Mediating; Medical Care Research; Methods; NCI; NCI Organization; National Cancer Institute; Nurses; Nursing, Team; Outcome; PROV; Paper; Patient Care; Patient Care Delivery; Patient Compliance; Patient Cooperation; Patient Education; Patient Instruction; Patient Training; Patients; Performance; Personnel, Nursing; Pharmacotherapy; Phone; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Printing; Process; Process Measure; Provider; Quality of Health Care; Quality of Healthcare; Randomized; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Resources; Resources; Sampling; Science; Scotine; Screening procedure; Secure; Self Management; Smoke; Smoker; Smoking Cessation Intervention; Smoking and Tobacco Use Cessation Interventions; Summary Reports; Survey Instrument; Surveys; System; System, LOINC Axis 4; Team Nursing; Technology; Telephone; Testing; Time; Tobacco; Tobacco Consumption; Tobacco use; Treatment Compliance; Visit; WWW; Work; base; cease smoking; compliance cooperation; enroll; experience; follow-up; health care delivery; health care quality; health care service; improved; innovate; innovation; innovative; interventional strategy; microsystems; multidisciplinary; patient adherence; point of care; public health relevance; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; recruit; response; screening; screenings; service intervention; services research; smoking cessation; success; therapy compliance; therapy cooperation; tobacco control; trial comparing; uptake; web; web site; world wide web",QUIT-PRIMO:Web-delivered Clinical Microsystem Intervention for Tobacco Control,"PUBLIC HEALTH RELEVANCE: This is our first resubmission of a randomized trial of QUIT-PRIMO Quality Improvement in Tobacco - Provider Referrals & Internet-delivered Microsystem Optimization in response to PA-06-226 Information Technologies and the Internet in Health Services and Intervention Delivery. Our Overall Goal is to advance science related to the use and impact of the Internet in health services delivery, specifically smoking cessation, by targeting primary care clinical microsystems. The QUIT-PRIIMO Intervention is a multi-component Internet-delivered clinical microsystem intervention with: 1. Refer2Quit A point-of-care patient referral portal providers can use to enroll patients into a self-management system, with summary reports of provider and patient activity, and secure messaging templates providers can use to efficiently encourage patients to quit during follow-up; AND 2. Decide2Quit A patient self-management portal organizing interactive, tailored, patient education, cessation planning, links to other high-quality web (smokefree.gov) and offline resources (1-800-QUIT-NOW), and secure messaging patients can use.",129091,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,4,625767,
7753158,R01,CA,5,,01/01/2010,12/31/2010,PA-07-070,5R01CA129102-02,,NCI:252698;,2010,NATIONAL CANCER INSTITUTE,,ANN ARBOR,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"TAYLOR, JEREMY MG;",1864035;,5R01CA129102,01/01/2009,12/31/2011,"Address; Advocate; Area; Blood Tests; Cancers; Critical Paths; Critical Pathways; Data; Data Set; Dataset; Detection; Development; Diagnosis; Disease; Disorder; Early Diagnosis; Genomics; Grant; Hematologic Tests; Hematological Tests; Hematology Testing; Hybrids; Investigators; Isokinetic Exercise; Isokinetics; Isotonic Exercise; Isotonics; Knowledge; Malignant Neoplasms; Malignant Tumor; Measurement; Measures; Medical Research; Method LOINC Axis 6; Methodology; Methods; Modeling; Models, Statistical; Monitor; Patients; Play; Probabilistic Models; Procedures; Proteomics; Research Personnel; Research, Medical; Researchers; Risk; Role; Staging; Statistical Methods; Statistical Models; Surrogate End Points; Surrogate Endpoint; Symptoms; Translational Research; Translational Research Enterprise; Translational Science; Work; base; biomarker; disease risk; disease/disorder; disorder risk; drug development; early detection; effective therapy; improved; malignancy; neoplasm/cancer; new technology; novel; public health relevance; randomized trial; social role; translation research enterprise",Statistical Methods for Cancer Biomarkers," Project Narrative: Statistical Methods for Cancer Biomarkers.  Biomarkers are measurements that can be taken from patient, for example from a simple blood test. Biomarkers do not measure how the patients feel or symptoms they have, never-the-less they may be very useful to give early detection of a disease, or to monitor how the treatment is working, or to assess whether a new treatment if effective. The aim of this grant is to develop valid methods of analysing datasets of biomarkers, that get the most information out of the data.",129102,ZRG1,Special Emphasis Panel,,2,252698,
7759621,R01,CA,5,,02/01/2010,01/31/2011,PAS-07-190,5R01CA129105-03,,NCI:423772;,2010,NATIONAL CANCER INSTITUTE,,CAMBRIDGE,UNITED STATES,,08,120989983,US,MA,021421479,WHITEHEAD INSTITUTE FOR BIOMEDICAL RES,"SABATINI, DAVID M;",1906293;,5R01CA129105,04/08/2008,01/31/2013,"ATP-protein phosphotransferase; Address; Affect; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animal Structures; Antioncogene Protein p53; Assay; BZS; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological Assay; Biological Function; Biological Process; Biology; Birds of Prey; CCOP; Cancer Cause; Cancer Etiology; Cancer Treatment; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Cellular Tumor Antigen P53; Chemistry, Biological; Collaborations; Community Clinical Oncology Program; Community Oncology; Complex; Crystallographies; Crystallography; DNA Molecular Biology; Data; Development; Disease; Disorder; Dose; EC 2.7; Electron Microscopy; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Future; G-Proteins; GAP Proteins; GFAC; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPase-Activating Proteins; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Male, Prostate; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; High Throughput Assay; Human; Human Prostate; Human Prostate Gland; Human, General; Humulin R; Image; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; KIAA0243; Kinases; Knockout Mice; LKB1; LKB1/STK11 Gene; Lead; Lesion; Lymphangioleiomyomatosis; Lymphangiomyomatosis; MHAM; MMAC1; Macromolecular Structure; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical; Methods; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Biology; Molecular Interaction; Molecular Structure; Murine; Mus; Mutation; Normal Cell; Novolin R; Null Mouse; Nutrient; Oncogenesis; Oncology Programs; Oncoprotein p53; Organism; PJS; PTEN; PTEN gene; PTEN1; Pathway interactions; Patients; Pb element; Phosphatase and Tensin Homolog; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Process; Prostate; Prostate Adenocarcinoma; Prostate Gland; Prostate Gland Adenocarcinoma; Prostatic Gland; Protein Kinase; Protein Phosphorylation; Protein TP53; Protein p53; Proteins; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Raptors; Research; Resolution; Role; STK11; STK11 gene; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Stress; Structure; Syndrome; TP53; TSC1; TSC1 gene; TSC2; TSC2 gene; Testing; Therapeutic; Tissue Growth; Transphosphorylases; Tsc1 [{C0694894}]; Tuberous sclerosis protein complex; Tumor Protein p53; Tumor Suppressor Proteins; Work; anticancer therapy; biological signal transduction; cancer therapy; cell growth; disease/disorder; drug development; gene product; genome mutation; glycogen synthase a kinase; guanosinetriphosphatase activating protein; heavy metal Pb; heavy metal lead; high throughput screening; human FRAP1 protein; human disease; hydroxyalkyl protein kinase; imaging; inhibitor; inhibitor/antagonist; insight; intervention development; living system; mTOR; mTOR Inhibitor; malignancy; model organism; mouse model; neoplasm/cancer; novel; ontogeny; p53 Antigen; p53 Tumor Suppressor; pathway; phosphorylase b kinase kinase; prostatic adenocarcinoma; public health relevance; rapamycin and FKBP12 target 1 protein, human; response; small molecule; social role; structural biology; therapy development; tool; treatment development; tuberous sclerosis complex; tumor; tumor suppressor; tumorigenesis",Cell Growth Signaling in Cancer Development,,129105,CSRS,Cellular Signaling and Regulatory Systems Study Section,,3,423772,
7766926,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129339-03,,NCI:352750;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"SENGER, DONALD R;",1872198;,5R01CA129339,03/14/2008,01/31/2013,Anti-Angiogenesis; Antiangiogenesis; Architecture; Blood Vessel Tumor; Blood Vessels; Blood flow; Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cancer Patient; Cancer Radiotherapy; Cancer Treatment; Cancerous; Cancers; Cellular Matrix; Clinical; Clinical Research; Clinical Study; Cytoskeletal System; Cytoskeleton; Cytotoxic agent; Cytotoxic drug; Defect; Desminase; Development; Disease; Disorder; Dose; Drug Combinations; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Targeting; Drug Targetings; Drugs; Effectiveness; Elements; Endothelial Cells; Engineering / Architecture; Esteroproteases; Exhibits; Family; Forecast of outcome; GTP Phosphohydrolases; GTPases; Goals; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hypoxia; Hypoxic; Killings; Lead; Link; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Measures; Mediating; Medication; Modeling; Morphogenesis; Neoplasms in Vascular Tissue; Neovasculature; O element; O2 element; Outcome; Oxygen; Oxygen Deficiency; Papain-Like Cysteine Protease; Patients; Pb element; Peptidases; Peptide Hydrolases; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Prognosis; Proteases; Proteinases; Proteolytic Enzymes; Radiation therapy; Radiotherapeutics; Radiotherapy; Reaction Time; Research; Response RT; Response Time; Scheme; Signal Pathway; Solid Neoplasm; Solid Tumor; Testing; Therapeutic; Time; Tumor Angiogenesis; Tumor Oxygenation; Tumor-Associated Vasculature; Validation; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Work; antiangiogenesis therapy; anticancer therapy; blood vessel neoplasm; cancer progression; cancer therapy; chemotherapeutic agent; chemotherapy; design; designing; disease/disorder; drug development; drug/agent; efficacy testing; experiment; experimental research; experimental study; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; improved; intracellular skeleton; irradiation; malignancy; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; neovasculature; new approaches; novel approaches; novel strategies; novel strategy; outcome forecast; preclinical study; psychomotor reaction time; public health relevance; research study; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; tumor; tumor progression; vascular; vessel regression,Rectifying defects in tumor vasculature to improve chemo- and radiation therapies,,129339,DT,Developmental Therapeutics Study Section,,3,352750,
7756580,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129377-03,,NCI:239794;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"DECLERCK, YVES A;",8760986;,5R01CA129377,04/01/2008,01/31/2013,"Affect; Angiogenic Factor; Angiogenic Switch; Animal Model; Animal Models and Related Studies; Antibodies; Apoptosis; Apoptosis Antigen Ligand 1; Apoptosis Pathway; Apoptotic; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Blood Clot; Blood Clotting; Blood Vessels; Blood coagulation; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Brain; CD178 Antigen; CD95 Ligand; CD95 antigen ligand; Cancer Staging; Cancer of Breast; Cancers; Cell Attachment; Cell Death, Programmed; Cell membrane; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Clinical; Cold-Insoluble Globulins; Complement S-Protein; Critical Paths; Critical Pathways; Cytoplasmic Membrane; DNA Synthesis Factor; Data; Diabetic Retinopathy; Diagnostic Neoplasm Staging; Disease; Disorder; ECGF; Encephalon; Encephalons; Endothelial Cell Growth Factor; Endothelial Cells; Epibolin; Extracellular Matrix Proteins; FGF; FN1; FNZ; Factor, Angiogenesis; Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Fibrinolysin; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Fibronectin 1; Fibronectins; Glu-Plasmin; HBGF; Human; Human, General; Hypoxia; Hypoxic; In Vitro; Intervention; Intervention Strategies; Knockout Mice; LETS Proteins; Laboratories; Large External Transformation-Sensitive Protein; Left; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mice, Knock-out; Mice, Knockout; Moab, Clinical Treatment; Molecular Weight; Monoclonal Antibodies; Murine; Mus; Neoplasm Metastasis; Neoplasm Staging; Nervous System, Brain; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Non-Malignant; Null Mouse; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Outcome; Oxygen Deficiency; PAI-1; PAI1; PLANH1; PLAU; Pathway interactions; Patients; Plasma Membrane; Plasmin; Plasminogen Activator Inhibitor 1; Plasminogen Activator, Urokinase; Play; Primary Neoplasm; Primary Tumor; Process; Production; Protease F; Protein Cleavage; Proteins; Proteolysis; Reporting; Research Proposals; Reticuloendothelial System, Bone Marrow; Role; Secondary Neoplasm; Secondary Tumor; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Serum Spreading Factor; Source; Stromal Cells; Testing; Therapeutic; Thrombosis; Transplantation; Tumor Angiogenesis; Tumor Cell; Tumor Cell Migration; Tumor Necrosis Factor Ligand Superfamily Member 6; Tumor Staging; Tumor-Derived; Type 1 Plasminogen Activator Inhibitor; U-PA; U-PA receptor; U-Plasminogen Activator; UPA; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urinary Plasminogen Activator; Urokinase; Urokinase Plasminogen Activator Receptor; Urokinase Receptor; Urokinase-Type Plasminogen Activator; Urokinase-type Plasminogen Activator Receptor; VTN; Vascular Endothelial Cell; Vitronectin; alpha 2-Surface Binding Glycoprotein; angiogenesis; atherogenesis; atheromatosis; atherosclerotic vascular disease; base; cancer metastasis; cancer progression; disease/disorder; experiment; experimental research; experimental study; extracellular; gene product; human disease; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; knock-down; malignancy; malignant breast neoplasm; migration; model organism; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; nonmalignant; pathway; plasmalemma; pre-clinical; preclinical; prevent; preventing; protective effect; public health relevance; receptor, pro-urokinase; reconstitute; reconstitution; research study; shRNA; short hairpin RNA; small hairpin RNA; small molecule; social role; therapeutic target; transplant; tumor; tumor growth; tumor progression; uPAR receptor; vascular",Plasminogen activator inhibitor-1 in tumor progression and metastasis,,129377,TPM,Tumor Progression and Metastasis Study Section,,3,239794,
7755824,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129382-03,,NCI:337189;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,PEDIATRICS,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"FERRANDO, ADOLFO A;",8256640;,5R01CA129382,04/01/2008,01/31/2013,"AKT; AKT Signaling Pathway; APP Secretase; Accounting; Acute T Cell Leukemia; Adult ALL; Adult Acute Lymphoblastic Leukemia; Adult Acute Lymphocytic Leukemia; Adult Acute Lymphogenous Leukemia; Adult Acute Lymphoid Leukemia; Akt protein; Amyloid Precursor Protein Secretase; Animal Model; Animal Models and Related Studies; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Autoregulation; BZS; Blood (Leukemia); Cancer Genes; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Cycle Arrest; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Center for Cancer Research; Childhood; Clinical Trials; Clinical Trials, Unspecified; Data; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Effectiveness; Emerogenes; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Goals; Growth; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Cancer; Homeostasis; Human; Human, General; Immunoglobulin Enhancer-Binding Protein; In Vitro; Intracellular Communication and Signaling; Knockout Mice; Leukemia, Lymphocytic; Leukemia, T-Cell; Leukemias, General; Lymphoblastic Leukemia; Lymphoblastic Leukemia, Acute, T-Cell; Lymphocytic Leukemia, T-Cell; Lymphocytic Leukemia, T-Cell, Acute; Lymphoid Leukemia; MHAM; MMAC1; Malignant Hematologic Neoplasm; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Mother Cells; Murine; Mus; Mutation; NCI Center for Cancer Research; NF-kB; NF-kappa B; NF-kappaB; NFKB; NOTCH1; NOTCH1 gene; New York; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Oncogene Products; Oncogene Proteins; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenic; Oncoproteins; PI-3K/AKT; PI3K/AKT; PKB protein; PTEN; PTEN gene; PTEN1; Pathogenesis; Pathway interactions; Phosphatase and Tensin Homolog; Physiological Homeostasis; Play; Precursor T Lymphoblastic Leukemia; Progenitor Cells; Protein Kinase B; Proto-Oncogene Proteins c-akt; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Receptor Protein; Research; Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stem Cell Leukemia; Stem cells; T-Cell Development; T-Cell Leukemia; T-Cell Ontogeny; T-Cell Transformation; T-Cell Type Acute Leukemia; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocytic Leukemia; T-Lymphocytic Leukemia, Acute; TAN1; Testing; Thymus-Dependent Lymphocytes; Tissue Growth; Transcription Factor NF-kB; Transforming Genes; Transplantation; Tumor Suppressing Genes; Tumor Suppressor Genes; Up-Regulation; Up-Regulation (Physiology); Upregulation; antileukemic agent; base; biological signal transduction; c-akt protein; cell growth; clinical investigation; cultured cell line; disease/disorder; experiment; experimental research; experimental study; genetic analysis; genome mutation; hN1; human FRAP1 protein; inhibitor; inhibitor/antagonist; kappa B Enhancer Binding Protein; leukemia; lymphatic leukemia; lymphoblast; lymphogenous leukemia; mTOR; model organism; notch; notch protein; notch receptors; nuclear factor kappa beta; oncosuppressor gene; ontogeny; pathway; pediatric; progenitor; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; receptor; related to A and C-protein; research study; resistant; response; secretase; small molecule; social role; thymus derived lymphocyte; transplant; tumor",The role of AKT signaling in NOTCH1 induced leukemias,,129382,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,337189,
7762249,R01,CA,5,,02/01/2010,01/31/2011,PA-07-175,5R01CA129415-03,,NCI:240700;,2010,NATIONAL CANCER INSTITUTE,,BIRMINGHAM,UNITED STATES,BIOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"TOLLEFSBOL, TRYGVE O;",2061037;,5R01CA129415,04/01/2008,01/31/2012,"4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5-AC; 5-Aza-cytidine; 5-Azacytidine; 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide; AZC; Acetylation; Administration, Oral; Affect; Apoptosis; Apoptosis Pathway; Attention; Azacitidine; Azacytidine; Beverages; Binding; Binding (Molecular Function); Biological Models; Breast; Breast Cancer Cell; Breast Cancer Prevention; Cancer Cause; Cancer Control; Cancer Control Science; Cancer Etiology; Cancer Patient; Cancer of Breast; Cancers; Cell Death, Programmed; Cells; Cessation of life; Chemopreventive; Chemopreventive Agent; Chromosomes; DNA Methylation; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA-Methyltransferases; Death; Dietary Component; Dietary Factors; Dnmt; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Administration, Oral; E2F-1; E2F1; E2F1 gene; EC 2.1.1.113; EGCG; EGCG cpd; Enzymes; Epigallocatechin Gallate; Epigallocatechingallate; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Female; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes, Regulator; Goals; Green Tea Extract; Green Tea Polyphenols; Green tea (dietary); HDAC Agent; Histone Acetylation; Histone Deacetylase Inhibitor; Histone Deacetylation; Histones; Human Breast Cancer Cell; In Vitro; Incidence; Investigation; Laboratories; Lead; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measures; Mediating; Methods and Techniques; Methods, Other; Methylation; Model System; Modeling; Models, Biologic; Modification Methylases; Molecular Interaction; Oncogenesis; Oral; Oral Administration; Outcome Study; Pathway interactions; Pb element; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevention therapy; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Methylation; Quelling; RBBP3; RBP3; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Regulator Genes; Reporting; Role; Sequence-Specific Posttranscriptional Gene Silencing; Site-Specific DNA-methyltransferase; Study, Outcome; TERT gene; TSA antibioitc; Tea; Tea catechin; Techniques; Telomerase; Telomerase Reverse Transcriptase Catalytic Subunit Gene; Telomerase inhibition; Toxic effect; Toxicities; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transcriptional Regulatory Elements; Trichostatin A; United States; Work; anticarcinogenic; breast tumorigenesis; cancer cell; cancer prevention; cancer progression; chemotherapy; cytotoxic; epigallo-catechin gallate; epigallocatechin; epigallocatechol; gallocatechin; gallocatechol; green tea; hTERT Gene; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; in vivo; intraoral drug delivery; ladakamycin; malignancy; malignant breast neoplasm; mammary cancer prevention; mammary tumor prevention; neoplasm progression; neoplasm/cancer; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; pathway; polyphenol; pre-clinical; preclinical; prevent; preventing; public health relevance; regulatory gene; response; social role; trans acting element; transcription factor; tricostatin A; tumor; tumor progression; tumorigenesis",Epigenetics of Tea Polyphenols in Cancer Prevention,,129415,CDP,Chemo/Dietary Prevention Study Section,,3,240700,
7758732,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129424-03,,NCI:317973;,2010,NATIONAL CANCER INSTITUTE,,ATLANTA,UNITED STATES,OBSTETRICS & GYNECOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"SIDELL, NEIL ;",1945889;,5R01CA129424,04/01/2008,01/31/2012,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile); Affect; Androstenedione Aromatase; Androstenedione Aromatase Inhibitor; Animal Model; Animal Models and Related Studies; Anti-Estrogens; Antiestrogen Therapy; Antiestrogens; Aromatase; Aromatase Cytochrome P450; Aromatase Inhibitors; Arts; Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-; Binding; Binding (Molecular Function); Binding Sites; Binding, Competitive; Biological; Biological Testing; Body Tissues; Breast Cancer Cell; Breast Cancer Treatment; Breast Neoplasms; Breast Tumors; CYP 19; CYP19 Protein; CYPXIX; Cancer Induction; Cancer Treatment; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chromatin; Clinical; Combining Site; Competitive Binding; Complex; Computer Simulation; Computerized Models; Computers; Consensus; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); DNA; DNA Binding; DNA Binding Interaction; DNA Intercalating Agent; DNA Sequence; DNA Structure; Data; Deoxyribonucleic Acid; Development; Drugs; ER Status; Elements; Endocrine Therapy; Engineering; Engineerings; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptor Status; Estrogen Receptors; Estrogen Synthase; Estrogen Synthase Inhibitor; Estrogen Synthetase; Estrogen Synthetase Inhibitor; Estrogen receptor positive; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Femara; GWAS; Gene Targeting; Gene Transcription; Genes; Genetic; Genetic Transcription; Genome; Goals; Hereditary; Hormonal; Hormonal Therapy; Hormone Responsive; Human Breast Cancer Cell; Inherited; Intercalating Agents; Intercalating Ligands; Intercalative Compounds; Intercalators; Intracellular Communication and Signaling; Length; Letrozole; Life; Ligands; Major Groove; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mediating; Medication; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice, Transgenic; Modality; Models, Computer; Models, Molecular; Molecular; Molecular Interaction; Molecular Models; Molecular Target; Nature; Novartis Brand of Letrozole; Nuclear Magnetic Resonance; Nucleic Acid Biochemistry, Molecular Modeling; Oligo; Oligonucleotides; P450AROM; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenazines; Predisposition; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Protocols, Treatment; Public Health; RGM; RNA Expression; Reactive Site; Receptor Inhibition; Regimen; Resistance; Response Elements; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Specificity; Staging; Structure; Susceptibility; TAM; Tamoxifen; Targetings, Gene; Techniques; Technology; Testing; Therapeutic; Therapeutic Estrogen; Therapeutic Intervention; Tissues; Transcription; Transcription, Genetic; Transgenic Mice; Transgenic Model; Treatment Protocols; Treatment Regimen; Treatment Schedule; Variant; Variation; Woman; Work; anticancer therapy; antiestrogen; antiestrogenic; base; biological signal transduction; cancer cell; cancer therapy; carcinogenesis; chemotherapy; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; drug candidate; drug/agent; effective therapy; estrogen inhibitor; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hormone therapy; in silico; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; malignancy; malignant breast neoplasm; mammary; mammary tumor; model organism; molecular modeling; mouse model; neoplasm/cancer; non-genomic; nongenomic; novel; overexpression; pathway; piperidinedione; prototype; public health medicine (field); receptor binding; resistant; response; small molecule; standard care; transcription factor; treatment effect; tumor; virtual simulation; whole genome association studies; whole genome association study",Development and Testing of ERE-Targeting Molecules for Breast Cancer Therapy,,129424,DMP,Drug Discovery and Molecular Pharmacology Study Section,,3,317973,
7758781,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129521-03,,NCI:301290;,2010,NATIONAL CANCER INSTITUTE,,AUSTIN,UNITED STATES,PHARMACOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"BRATTON, SHAWN B;",1906376;,5R01CA129521,04/08/2008,01/31/2013,"70-kD Heat-Shock Protein; APP Secretase; Address; Alkalinization; Amyloid Precursor Protein Secretase; Apopain; Apoptosis; Apoptosis Inhibitor; Apoptosis Pathway; Apoptotic; Applications Grants; Area; Attenuated; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cachectin; Cachectin Receptors; Cachectin-Tumor Necrosis Factor; Cancer Radiotherapy; Cancers; Caspase 3, Apoptosis-Related Cysteine Protease; Cathepsin B1; Cathepsins; Cathepsins B; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cells; Cleaved cell; Clinic; Clinical Trials; Clinical Trials, Unspecified; Complex; Convulsive therapy; Cysteine Protease CPP32; Cytoplasm; Cytoplasmic Granules; Cytosol; Data; Drugs; EC 2.7; EC 3.4.22.1; Embryo; Embryonic; Environment; Family member; Fever; Fibroblasts; Future; Gene Combinations; Grant; Grant Proposals; Grants, Applications; H+ element; HSP; HSP 70; HSP70; Heat Shock; Heat shock proteins; Heat-Shock Proteins 70; Heat-Shock Reaction; Heat-Shock Response; Heating; Hydrogen Ions; Hyperthermia; ICE-like protease; Ich-1 protein; Imidazole; Intracellular Communication and Signaling; Investigation; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; Kinases; Lead; Light; MAP Kinase 8; MAP Kinase Kinase Kinase; MAP Kinase Kinases; MAP3 Kinases; MAPK Kinases; MAPK8 Mitogen-Activated Protein Kinase; MAPKKKs; MAPKKs; MGC[{..}]45012; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Medication; Membrane; Mice; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Modeling; Murine; Mus; Nedd-2 protein; Outer Mitochondrial Membrane; PARP Cleavage Protease; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphotransferases; Photoradiation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Proteins; Protons; Publications; Pyrexia; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA-Binding Proteins; RNAi; Radiation; Radiation therapy; Radiotherapeutics; Radiotherapy; Regulation; Reporting; Resistance; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SCA-1; SREBP Cleavage Activity 1; Scientific Publication; Sequence-Specific Posttranscriptional Gene Silencing; Shock Therapy; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Stream; Stress; Stress Proteins; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; TNF (unspecified); TNF Receptor Family Protein; TNF Receptor Ligands; TNF Receptor Superfamily; TNF Receptor-Associated Factors; TNF Receptors; TNF-alpha; TNFR; TRAF Proteins; TRAF2; TRAF2 gene; TRAP3; Testing; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Associated Factors; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Work; Yama; Yama protein; abstracting; aposome; base; biological signal transduction; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; caspase; caspase-2; caspase-3; caspase-activating complex; cell killing; cellular targeting; chemotherapy; cleaved; clinical investigation; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; drug/agent; endoplasmic reticulum stress; febrile; febris; gene product; granule; heavy metal Pb; heavy metal lead; hsp70 Family; improved; inhibitor; inhibitor/antagonist; insight; interest; irradiation; jun-NH2-Terminal Kinase; malignancy; membrane structure; mitochondrial; necrocytosis; neoplasm/cancer; novel; overexpression; pathway; prevent; preventing; pro-caspase-3; procaspase-3; ray (radiation); resistant; response; social role; stress-activated protein kinase 1; tumor necrosis factor (unspecified)",Heat shock-induced apoptosis,,129521,CAMP,Cancer Molecular Pathobiology Study Section,,3,301290,
7758311,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129528-03,,NCI:283656;,2010,NATIONAL CANCER INSTITUTE,,SALT LAKE CITY,UNITED STATES,PHARMACOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"LIM, CAROL S;",1926845;,5R01CA129528,04/01/2008,01/31/2013,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 4-3 Hydrophobic Repeat; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; ABL; ANXA5; API4; ATP[{..}]protein-tyrosine O-phosphotransferase; Aacidexam; Abelson Murine Leukemia Viral Oncogene Homolog; Accounting; Active Transport, Cell Nucleus; Address; Adexone; Adverse effects; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amino Acids; Amplidermis; Anchorin CII; Anemul mono; Animal Model; Animal Models and Related Studies; Animals; Annexin A5 Protein; Annexin V; Antimicotico; Apoptosis; Apoptosis Inhibitor; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; Apoptosis Pathway; Apoptotic; Aquapred; Assay; Athymic Nude Mouse; Auxiloson; Azona; BIRC5; Back; Baculoviral IAP Repeat-Containing 5 (Survivin); Baculoviral IAP Repeat-Containing Protein 5; Baycuten; Baycuten N; Binding; Binding (Molecular Function); Binding Site Domain; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Blood (Leukemia); Blood granulocytic cell; Breast Cancer Cell; CAGA; CBP-I; CGLA; Calphobindin I; Cancer Genes; Cancer-Promoting Gene; Cancers; Causality; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cell-Death Protease; CellLine; Cells; Cellular Morphology; Cellular Proliferation; Chronic Myeloid Leukemia; Chronic Phase; Chronic Phase of Disease; Clinical; Cloning; Coiled-Coil Domain; Combining Site; Complex; Corson; Cortidexason; Cortisumman; Cytoplasm; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Dorsum; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EPR-1; Endonexin II; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-; Etiology; Export, Nuclear; Family; Female; Fluorescence; Fluorescence Microscopy; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Gammacorten; Gene Transcription; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic Transcription; Genetic defect; Gleevec; Glivec; Goals; Granular Leukocytes; Granulocytic cell; HEK3; Hexadecadrol; Hexadrol; Human; Human Breast Cancer Cell; Human, General; IAP4; ICE-like protease; Imagery; Imatinib mesylate; Immune Precipitation; Immunoblotting; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunoprecipitation; Immunosuppressed Host; Intervention, Genetic; Intracellular Communication and Signaling; K-562; K562; K562 Cells; K562 blasts; LEUKCL; Left-Handed Twist; Length; Leukemia, Granulocytic, Chronic; Leukemias, General; Leukemic Cell; Ligand Binding Domain; Ligands; Lipocortin-V; Location; Lokalison-F; Loverine; MA387; MRP8; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Messenger RNA; Metabolic Diseases; Metabolic Disorder; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Methylfluorprednisolone; Mice; Mice, Athymic; Mice, Nude; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mifegyne; Mifeprex; Mifepristone; Millicorten; Modality; Modeling; Molecular Biology, Gene Therapy; Molecular Interaction; Monitor; Murine; Mus; Mutagenesis, Site-Directed; Mutate; Mutation; Myelocytic Leukemia, Chronic; Myelogenous Leukemia, Chronic; Myeloid Cells; Myeloid Disease; Myeloid Leukemia, Chronic; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; Mymethasone; NLS Peptide; Normal Cell; Nuclear; Nuclear Export; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Nuclear Transport; Nucleocytoplasmic Shuttling; Nucleus; Nude Mice; Ocasa; Oncogene ABL1; Oncogenes; Oncogenesis; Oncogenic; Orgadrone; Output; PAP-I; PP4; PTK; PTK Inhibitors; Paper; Patients; Peptide Signal Sequences; Placental Anticoagulant Protein I; Placental Protein 4; Plasmids; Play; Point Mutation; Polymers; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase Inhibitors; Proteins; RNA Expression; RNA, Messenger; RT-PCR; RTPCR; Reactive Site; Resistance; Resistance development; Resistant development; Reverse Transcriptase Polymerase Chain Reaction; Role; S100A8; S100A8 gene; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specificity; Spersadex; Spersadox; Staining method; Stainings; Stains; TK Inhibitors; Targeted DNA Modification; Targeted Modification; Techniques; Telomerase; Testing; Therapeutic; Therapeutic Intervention; Therapy, DNA; Thesaurismosis; Thromboplastin Inhibitor; Time; Transcription; Transcription, Genetic; Transfection; Transforming Genes; Treatment Side Effects; Tumor Cell; Tumor Suppressor Proteins; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Tyrosine Kinase; Tyrosine Kinase Inhibitor; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; VAC-Alpha; Vascular Anticoagulant-Alpha; Viral; Visualization; Visumetazone; Work; Xenograft Model; abl Oncogene; aminoacid; annexin A5; auricularum; biological signal transduction; caspase; cell morphology; clinical relevance; clinically relevant; cultured cell line; cystein protease; cystein proteinase; cysteine endopeptidase; developing resistance; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gene product; gene therapy; genetic therapy; genome mutation; granulocyte; hydroxyaryl protein kinase; immortalized cell; immunosuppressed patient; in vivo; intervention therapy; leukemia; mRNA; malignancy; member; metabolism disorder; model organism; myeloproliferative neoplasm; necrocytosis; neoplasm/cancer; neoplastic cell; new approaches; non-oncogenic; novel approaches; novel strategies; novel strategy; nucleocytoplasmic transport; protein function; protein signal sequence; resistant; reverse transcriptase PCR; side effect; social role; standard measure; survivin; therapy adverse effect; treatment adverse effect; tumor; tumor eradication; tumor suppressor; tumorigenesis; tyrosyl protein kinase; v abl; v-abl Genes; v-abl Oncogenes",Converting an Oncogene to an Apoptotic Factor by Manipulating Signal Sequences,,129528,GDD,Gene and Drug Delivery Systems Study Section,,3,283656,
7798244,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129682-02,,NCI:321833;,2010,NATIONAL CANCER INSTITUTE,,HERSHEY,UNITED STATES,PHARMACOLOGY,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"WANG, HONG-GANG ;",3127624;,5R01CA129682,04/01/2009,01/31/2014,"1-Phosphatidylinositol 3-Kinase; 4-3 Hydrophobic Repeat; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Ablation; Amino Acids; Apoptosis; Apoptosis Pathway; Apoptotic; Athymic Nude Mouse; Autoimmune Diseases; Autophagocytosis; Autophagosome; Autoregulation; Binding; Binding (Molecular Function); Binding Proteins; Biogenesis; Birth; Body Tissues; Breast; Cancer Treatment; Cancer of Lung; Cancer of the Ovary; Cancers; Carcinoma; Carcinoma of the Liver Cells; Cell Death, Programmed; Cells; Cellular Stress; Charge; Coiled-Coil Domain; Colon; Complex; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Digestion; Disease; Disorder; Docking; EC 2.7; Eating; Embryo; Embryonic; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Family member; Figs; Figs - dietary; Food Intake; Frequencies (time pattern); Frequency; GeneHomolog; Generations; Genes; Genetic Screening; Genital System, Male, Prostate; Germinoblastoma; HCC; Haploid; Haploidy; HeLa; Hela Cells; Hepatic Lymphoma; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Homeostasis; Homolog; Homologous Gene; Homologue; Human; Human Prostate; Human Prostate Gland; Human, General; In Vitro; Kinases; Knock-out; Knockout; Knockout Mice; Left-Handed Twist; Ligand Binding Protein; Lipid Binding; Liposomal; Liposomes; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma of the Liver; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Malignant; Lymphoma, Mantle-Cell; Lymphoma, Small-Cell, Centrocytic; Lysosomes; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Lung; Malignant Tumor of the Ovary; Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse; Malignant neoplasm of lung; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Mantle-Zone Lymphoma; Mediating; Membrane; Mice; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Microscopy; Mitochondria; Modeling; Molecular; Molecular Interaction; Murine; Mus; N-terminal; NH2-terminal; Neonatal; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nude Mice; Null Mouse; Nutrient; Oncogenesis; Organelles; Origin of Life; PI-3 Kinase; PI-3K; PI3-Kinase; Parturition; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphotransferases; Physiological Homeostasis; Play; Prevention strategy; Preventive strategy; Primary carcinoma of the liver cells; Process; Proline-Rich Domain; Proline-Rich Region; Prostate; Prostate Gland; Prostatic Gland; Protein Family; Proteins; PtdIns 3-Kinase; Pulmonary Cancer; Pulmonary malignant Neoplasm; Recruitment Activity; Regulation; Reporting; Reticulolymphosarcoma; Retrieval; Role; Sarcoma, Germinoblastic; Shapes; Staging; Starvation; Stimulus; Stomach; Structure; System; System, LOINC Axis 4; Testing; Time; Tissues; Transphosphorylases; Tumor Suppressor Proteins; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; VESCL; Vesicle; Wild Type Mouse; Yeasts; age dependent; age related; aminoacid; amphiphysin; anticancer therapy; autoimmune disorder; autophagy; cancer cell; cancer progression; cancer therapy; chemotherapy; deprivation; dimer; disease/disorder; driving force; epithelial carcinoma; gastric; gene product; implementation research; insight; lung cancer; malignancy; member; membrane structure; microbial; mitochondrial; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; neurodegenerative illness; novel; ovarian cancer; pathogen; public health relevance; recruit; response; social role; tumor; tumor growth; tumor progression; tumor suppressor; tumorigenesis",Regulation of Autophagy and Tumorigenesis by Bif-1," Project Narrative: We believe that successful implementation of this research will not only gain novel insight into the origin of isolation membranes and the molecular mechanism responsible for autophagic vesicle nucleation and expansion, but will also contribute to the establishment of new strategies for the prevention and treatment of cancer through manipulation of autophagy.",129682,CAMP,Cancer Molecular Pathobiology Study Section,,2,321833,
7756692,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129684-03,,NCI:600462;,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"XU, JIANFENG ;",6378758;,5R01CA129684,04/04/2008,01/31/2012,"Active Follow-up; Affect; Articulation; Base of Human Prostate; Base of the Prostate; Cancer Genes; Cancer Patient; Cancer of Prostate; Cancer-Promoting Gene; Cancers; Candidate Disease Gene; Candidate Gene; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Causality; Characteristics; Data; Diagnosis; Diathesis; Disease; Disease Association; Disease Progression; Disease susceptibility; Disorder; Etiology; Follow-Up Studies; Followup Studies; Frequencies (time pattern); Frequency; Funding; GWAS; Genes; Genetic; Genetic Markers; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genome; Genomics; Genotype; Grant; HOSP; Hereditary; Hospitals; Inherited; Inherited Predisposition; Inherited Susceptibility; Investigators; Joints; Lead; Linkage Disequilibrium; Linkage Disequilibriums; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Maps; Methods; NIH RFA; Nature; Oncogenes; Pathway interactions; Pb element; Phenotype; Polymorphism, Single Base; Population; Population Study; Prevention; Probability; Prostate CA; Prostate Cancer; Prostatic Cancer; Request for Applications; Research Design; Research Personnel; Researchers; Risk; Role; SNP; SNPs; Sample Size; Single Nucleotide Polymorphism; Staging; Stratification; Structure of base of prostate; Study Subject; Study Type; Sweden; Testing; Time; Transforming Genes; Universities; Variant; Variation; Work; association test; cancer genome; cancer risk; case control; clinical relevance; clinically relevant; design; designing; disease causation; disease etiology; disease risk; disease/disorder; disease/disorder etiology; disease/disorder proneness/risk; disorder etiology; disorder risk; experience; follow-up; forest; genetic association; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; genotyping technology; heavy metal Pb; heavy metal lead; improved; liability to disease; malignancy; men; men's; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; pathway; population based; public health relevance; social role; study design; success; whole genome association studies; whole genome association study",Confirmation of SNPs Associated with Aggressive PCa in a GWA Study,"PUBLIC HEALTH RELEVANCE: We propose to identify inherited sequence variants in the genome that confer moderate risk to prostate cancer (PCa) using a genome-wide association (GWA) study among more than 10,000 subjects from multiple study populations. The identified genes may advance our understanding on the etiology of PCa and could be used to better predict the risk for developing PCa. The focus on aggressive PCa is particularly important because this is the most clinically relevant form of PCa.",129684,ZRG1,Special Emphasis Panel,,3,600462,
7755892,R01,CA,5,,02/01/2010,01/31/2011,PA-07-187,5R01CA129765-03,,NCI:307158;,2010,NATIONAL CANCER INSTITUTE,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"WICHA, MAX S.;",1876580;,5R01CA129765,04/01/2008,01/31/2013,"AKT; Address; Akt protein; Aldehydes; BZS; Biological; Body Tissues; Breast; Breast Cancer Prevention; Breast Carcinoma; Breast Neoplasms; Breast Tissue; Breast Tumors; Cancer Cause; Cancer Etiology; Cancer Induction; Cancer of Breast; Cancer stem cell; Cancers; Carcinoma, Intraductal; Cell Components; Cell Function; Cell Process; Cell Structure; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Structures; Cessation of life; DCIS; Death; Development; Ductal Breast Carcinoma In Situ; Ductal Carcinoma In Situ; Ductal Hyperplasia; ERBB2; ERBB2 gene; Early Diagnosis; Epithelial; Epithelium; Erinaceidae; Event; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Familial Breast Carcinoma; Familial Cancer of the Breast; Ferredoxin[{..}]H+ oxidoreductase; Formalin; Generalized Growth; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Growth; HER -2; HER-2; HER2; HER2/neu; Hedgehogs; Hereditary; Hereditary Breast Cancer; Hereditary Breast Carcinoma; Heterogeneity; Histologic; Histologically; Human; Human EGF Receptor 2 Gene; Human, General; Hydrogenase; Hydrogenlyase; In Situ; In Vitro; Inherited; Intraductal Carcinoma of the Breast; Intraductal Hyperplasia; Laboratories; Lead; Lesion; Link; MHAM; MMAC1; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Carcinoma; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Glands, Human; Mammary Neoplasms; Mammary Tumorigenesis; Mammary gland; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Molecular; Mother Cells; Murine; Mus; NOD/SCID mouse; Non-Infiltrating Ductal Breast Adenocarcinoma; Non-Infiltrating Ductal Carcinoma of the Breast; Non-Infiltrating Intraductal Adenocarcinoma; Non-Infiltrating Intraductal Breast Adenocarcinoma; Non-Infiltrating Intraductal Carcinoma; Non-Invasive Ductal Breast Adenocarcinoma; Non-Invasive Ductal Carcinoma of the Breast; Non-Invasive Intraductal Breast Adenocarcinoma; Noninfiltrating Intraductal Carcinoma; Oncogenesis; PKB protein; PTEN; PTEN gene; PTEN1; Paraffin Embedding; Pathway interactions; Pb element; Phosphatase and Tensin Homolog; Phosphorylation; Play; Polycomb; Population; Pre-Malignant; Premalignant; Process; Progenitor Cells; Property; Property, LOINC Axis 2; Protein Kinase B; Protein Phosphorylation; Proto-Oncogene Proteins c-akt; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Regulation; Role; Signal Pathway; Stem cells; Subcellular Process; System; System, LOINC Axis 4; TKR1; Techniques; Testing; Tissue Growth; Tissues; Woman; Xenograft Model; abstracting; c-akt protein; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer initiation; carcinogenesis; early detection; heavy metal Pb; heavy metal lead; human FRAP1 protein; mTOR; malignancy; malignant breast neoplasm; mammary; mammary cancer prevention; mammary tumor; mammary tumor prevention; mouse model; neoplasm/cancer; new approaches; notch; notch protein; notch receptors; novel approaches; novel strategies; novel strategy; ontogeny; pathway; precancerous; prevent; preventing; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; related to A and C-protein; self-renewal; social role; stem; stem cell population; tool; tumor; tumorigenesis",Stem Cell Self-Renewal mammary Carcinogenesis,,129765,CAMP,Cancer Molecular Pathobiology Study Section,,3,307158,
7772242,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129813-03,,NCI:318513;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"BYERS, STEPHEN W;",1869415;,5R01CA129813,03/04/2008,01/31/2013,"(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol; 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-; AF 2; AF2; APC - Adenomatous Polyposis Coli; Ablation; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Adverse effects; Affect; Agonist; Alleles; Allelomorphs; Animal Cancer Model; Animal Feed; Animal Model; Animal Models and Related Studies; AnimalModel; Animals; Assay; Azoxymethane; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Bowel Cancer; CTNNB1; CUL-2; Ca++ element; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Calciol; Calcium; Cancer Cause; Cancer Etiology; Cancers; Catenin, Beta-1; Cell Communication and Signaling; Cell Signaling; Cells; Cessation of life; Chemopreventive; Chemopreventive Agent; Cholecalciferol; Coagulation Factor IV; Colon Cancer; Colon Carcinoma; Colonic Cancer; Colonic Carcinoma; Colorectal Cancer; DRIP205; Data; Death; Development; Diazene, dimethyl-, 1-oxide; Diet Supplement; Dietary Supplements; Dietary intake; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Epithelium; Exhibits; Factor IV; Familial Adenomatous Polyposis Syndrome; Familial hypophosphatemic bone disease; Family; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth; Hereditary; Hereditary Adenomatous Polyposis Coli; Human; Human, General; Hyperplasia; Hyperplastic; Incidence; Inherited; Intestinal; Intestinal Cancer; Intestinal Neoplasia; Intestinal Neoplasms; Intestinal Tumor; Intestines; Intestines Cancer; Intestines Neoplasms; Intracellular Communication and Signaling; Knockout Mice; Lead; Libraries; Ligands; Malignant Cell; Malignant Colon Neoplasm; Malignant Colonic Neoplasm; Malignant Colonic Tumor; Malignant Intestinal Neoplasm; Malignant Intestinal Tumor; Malignant Neoplasm of the Intestine; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Intestine; Malignant tumor of colon; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Models, Structural; Molecular Interaction; Murine; Mus; Mutation; Neoplasms; Nuclear; Nuclear Receptors; Null Mouse; Nutritional Supplement; Oncogenesis; Oncogenic; PPAR Binding Protein; PPARBP; PPARG Binding Protein; PRO2286; Pathway interactions; Patients; Pb element; Peroxisome Proliferator-Activated Receptor Binding Protein; Phenotype; Play; Point Mutation; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Predisposition; Preventive; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Regimen; Regulation; Reporter; Resistance; Rickets, Hypophosphatemic; Rickets, Vitamin D-Resistant; Role; Screening procedure; Series; Side; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specificity; Specified; Structural Models; Sunlight; Susceptibility; TR-associated protein P220; TRAP220; TRIP2 (thyroid receptor interacting protein 2); Testing; Therapeutic; Thyroid Hormone Receptor-Associated Protein Complex, 220 KDa Subunit; Thyroid Receptor Interacting Protein 2; Time; Tissue Growth; Trans-Activation (Genetics); Transactivation; Transgenic Animals; Transgenic Mice; Treatment Side Effects; Tumor of the Intestines; Tumors; Two Hybrid; United States; VIT D; Vitamin D; Vitamin D 3; Vitamin D Analog; Vitamin D Response Element; Vitamin D3; Work; X linked hypophosphatemia in rickets; X-Linked Hypophosphatemic Rickets; Yeast One Hybrid System; Yeast One/Two-Hybrid System; analog; animal food; anticarcinogenic; beta catenin; biological signal transduction; bowel; cancer cell; familial adenomatous polyposis; familial hypophosphatemia in rickets; familial polyposis; feeding; genome mutation; heavy metal Pb; heavy metal lead; hypophosphatemia in rickets; in vivo; inhibitor; inhibitor/antagonist; intervention development; intestine growth; malignancy; malignant colon tumor; model development; model organism; mutant; neoplasia; neoplasm/cancer; neoplastic growth; ontogeny; p53 regulatory protein RB18A; pathway; programs; public health relevance; resistant; screening; screenings; side effect; simulation; small molecule libraries; social role; therapy adverse effect; therapy development; thyroid hormone receptor associated protein 220; thyroid hormone receptor-associated protein complex component TRAP220; treatment adverse effect; treatment development; tumor; tumorigenesis; virtual; vitamin D receptor-interacting protein complex component DRIP205; vitamin therapy; yeast two hybrid system",Beta-catenin-specific regulation of the vitamin D pathway in colon cancer,,129813,CDP,Chemo/Dietary Prevention Study Section,,3,318513,
7760579,R01,CA,5,,02/01/2010,01/31/2011,PAS-07-190,5R01CA129821-03,,NCI:282926;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,PHARMACOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"JIANG, YU ;",6809941;,5R01CA129821,04/01/2008,01/31/2013,"Address; Affect; Aggression; Aggressive behavior; Animals; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Apoptotic; Attenuated; Benign; Binding; Binding (Molecular Function); Brain; Cancer cell line; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Proliferation; Cessation of life; Complex; DNA Alteration; DNA mutation; Death; Defect; Disease; Disorder; Dysfunction; Emerogenes; Encephalon; Encephalons; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FK506-Binding Protein 1; FK506-Binding Protein 1A; FKBP-12; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Functional disorder; G-Proteins; GAP Proteins; GFAC; GTP Binding; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPase-Activating Proteins; Gene Alteration; Gene Mutation; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetic mutation; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Hamartin; Hamartoma; Heart; Hereditary Disease; Human; Human, General; In Vitro; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; KIAA0243; Kidney; Lesion; Link; Lung; Macrophilin-12; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Modeling; Molecular; Molecular Disease; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutation; Nature; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Nutrient; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Organ; Organ failure; Pathway interactions; Physiopathology; Process; Proteins; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Rapamycin-Binding Proteins; Regulation; Research; Respiratory System, Lung; Role; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Skin; Small G-Proteins; Small GTPases; Starvation; Subcellular Process; TSC1; TSC1 gene; TSC1 protein; TSC1 protein, human; TSC1/2; TSC1/2 gene; TSC1/TSC2; TSC2; TSC2 gene; TSC2 protein; TSC2 protein, human; TSC2/TSC1; Tacrolimus Binding Protein 1A; Testing; Therapeutic Agents; Tissue Growth; Tsc1 [{C0694894}]; Tuberin; Tuberous Sclerosis 2 Protein; Tuberous sclerosis protein complex; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Urinary System, Kidney; base; biological signal transduction; cell growth; chemotherapeutic agent; cultured cell line; deprivation; design; designing; disease/disorder; gene product; genetic disorder; genome mutation; guanosinetriphosphatase activating protein; hereditary disorder; human FRAP1 protein; human TSC1 protein; human TSC2 protein; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; mTOR; mTOR Inhibitor; mTOR Signaling Pathway; mTOR inhibition; malignancy; mutant; neoplasm/cancer; nervous system disorder; neurological disease; novel; oncosuppressor gene; ontogeny; pathophysiology; pathway; prevent; preventing; pulmonary; rapamycin and FKBP12 target 1 protein, human; renal; social role; therapeutic target; tuberin, TSC2; tuberous sclerosis complex; tumor; tumor suppressor; tumorigenesis",The Role of FKBP38 in tumorigenesis associated with Tsc deficiency,,129821,TCB,Tumor Cell Biology Study Section,,3,282926,
7768455,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129835-03,,NCI:301885;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"HUANG, LEAF ;",1864338;,5R01CA129835,03/07/2008,01/31/2013,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; (Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; Accounting; Adriamycine; Animals; Anti-Cancer Agents; Anti-Sense Oligonucleotides; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Antisense Agent; Antisense Oligonucleotides; Apoptosis; Apoptosis Pathway; Apoptotic; Athymic Nude Mouse; BCL-X Short Isoform; BCL-Xs protein; BCL2-Like 1, Short Isoform; BCL2-Related Protein 1, Short Isoform; BCL2L1; Bcl2-Related Protein, Short Isoform; Benchmarking; Best Practice Analysis; Blood Circulation; Bloodstream; Body Tissues; COX-2 protein; COX2; COX2 enzyme; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer of Lung; Cancer-Promoting Gene; Cell Death; Cell Death, Programmed; Cell surface; Cells; Cellular Oncogene; Chemotherapeutic Agents, Neoplastic Disease; Circulation; Clinical; Collaborations; Combined Modality Therapy; Cyclo-Oxygenase-2; Cyclooxygenase; Cytotoxic agent; Cytotoxic drug; DNA; DOX; Data; Deoxyribonucleic Acid; Disease model; Distal; Dose; Doxorubicin; Doxorubicina; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Kinetics; Drug Targeting; Drug Targetings; Drug or chemical Tissue Distribution; Drugs; EGFR; ERBB Protein; ERBB1; Encapsulated; Endocytosis; Ensure; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Genes; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Estrogen Receptors; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Exhibits; Extravasation; Follow-Up Studies; Followup Studies; Formulation; Formulations, Drug; Gene Expression Inhibitor; Gene Targeting; Generalized Growth; Genes; Genes, EGFR; Glycans; Goals; Growth; HER1; Half-Life; Half-Lifes; Heparin; Heparinic Acid; Human; Human, General; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Inflammatory Response; Inorganic Sulfates; Intravenous; Killings; Leakage; Ligands; Lipids; Liposomal; Liposomes; Liver; Lung; Lung Neoplasms; MDM 2; MDM2; MDM2 gene; Macrogols; Malignant Cell; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Melanoma Cell; Metastasis; Metastasis to the Lung; Metastasize; Metastatic Neoplasm; Metastatic Neoplasm to the Lung; Metastatic Tumor; Metastatic Tumor to the Lung; Mice; Mice, Athymic; Mice, Nude; Micro RNA; MicroRNAs; Modality; Modeling; Modification; Molecular Weight; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; Names; Nanoscale Science; Nanotechnology; Neoplasm Metastasis; Nude Mice; Oligo; Oligonucleotides; Oligonucleotides, Antisense; Oncogenes; PEG; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PTGS2; Particle Size; Pathway interactions; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Plasmids; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polyoxyethylenes; Polysaccharides; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protease Inhibitor 5; Proto-Oncogenes; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; RNA Splicing; RNA, Small Interfering; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Opioid, sigma; Receptors, sigma; Research; Respiratory System, Lung; SERPINB5 gene product; Secondary Neoplasm; Secondary Tumor; Small Interfering RNA; Solid Neoplasm; Solid Tumor; Spillage; Splicing; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Surface; System; System, LOINC Axis 4; TAM; Tamoxifen; Targetings, Gene; Testing; Therapeutic; Therapeutic Effect; Tissue Distribution; Tissue Growth; Tissues; Toxic effect; Toxicities; Transforming Genes; Transforming Growth Factor alpha Receptor; Tumor Burden; Tumor Cell; Tumor Cell Migration; Tumor Load; Tumor Suppression; Tumor Suppression, Molecular; Tumor of the Lung; Tumor-Specific Treatment Agents; Universities; Unspecified or Sulfate Ion Sulfates; VEGFs; Vascular Endothelial Growth Factors; Vegf; Xenograft Model; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; abstracting; anticancer activity; anticancer agent; anticancer drug; anticancer therapy; base; bcl-x(S) protein; bcl-xS; bcl-xS protein, human; bcl-xshort protein; body system, hepatic; c myc; c-ONC; c-erbB-1; c-erbB-1 Gene; c-erbB-1 Protein; c-erbB-1 Proto-Oncogenes; c-myc Genes; cancer cell; cancer metastasis; cancer therapy; cell killing; chemical property; combination therapy; combined modality treatment; combined treatment; cyclo-oxygenase II; cyclooxygenase 2; design; designing; disorder model; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; improved; in vivo; interest; lung cancer; maspin; maspin gene product; melanoma; miRNA; mouse model; multimodality therapy; nano particle; nano scale Science; nano tech; nano technology; nanoparticle; nanotech; necrocytosis; neoplastic cell; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; organ system, hepatic; p53-Binding Protein Gene; pathway; plasmid DNA; polycation; prostaglandin H synthase-2; proto-oncogene protein c-erbB-1; protooncogene; pulmonary; pulmonary metastasis; receptor; research study; self assembly; siRNA; sigma Receptors; site targeted delivery; sulfate; targeted delivery; therapeutic gene; tool; transcription factor; tumor; tumor growth; tumor xenograft; uptake; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; vector",LPD Nanoparticles in Anti-Cancer Therapy,,129835,DT,Developmental Therapeutics Study Section,,3,301885,
7780378,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129933-03,,NCI:367275;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HABER, DANIEL A.;",1886076;,5R01CA129933,04/01/2008,01/31/2013,"4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-4-morpholin] propoxy]; ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Affect; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Bioassay; Biologic Assays; Biological Assay; Cancer Drug; Cancer Genes; Cancer Treatment; Cancer cell line; Cancer of Lung; Cancer-Promoting Gene; Cancers; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chemotherapeutic Agents, Neoplastic Disease; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Clinical; Clinical Trials; Clinical Trials, Unspecified; Clinical effectiveness; Combination Chemotherapy Regimen; Complement; Complement Proteins; Complex; Dependence; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug resistance; Drugs; EC 2.7; EGFR; EGFR Blocker; EGFR Inhibitor; EGFR Tyrosine Kinase Inhibitor; EGFR-TK Inhibitor; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ERBB Protein; ERBB1; ERBB2; ERBB2 gene; Effectiveness; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Genes; Epidermal Growth Factor Receptor Inhibitor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epithelial; Erlotinib; Face; Family member; Gatekeeping; Gefitinib; Generations; Genes, EGFR; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Genetic; Genetic Alteration; Genetic Change; Genetic Markers; Genetic defect; Gleevec; Glivec; Growth Factor Receptors; HEK3; HER -2; HER-2; HER1; HER2; HER2/neu; Human; Human EGF Receptor 2 Gene; Human, General; Imatinib; In Vitro; Intracellular Communication and Signaling; Iressa; Kinases; L-tyrosine, dihydrogen phosphate (ester); Libraries; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Modeling; Molecular; Mutation; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Oncogenes; PTK; PTK Inhibitors; Pathway interactions; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphotransferases; Phosphotyrosine; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase Inhibitors; Proteomics; Proto-Oncogene, Growth Factor Receptor; Pulmonary Cancer; Pulmonary malignant Neoplasm; Quelling; Quimioterapia; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Receptor Signaling; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Resistance; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; TK Inhibitors; TKR1; Tarceva; Testing; Transforming Genes; Transforming Growth Factor alpha Receptor; Transphosphorylases; Tumor-Specific Treatment Agents; Tyrosine Kinase; Tyrosine Kinase Inhibitor; Tyrosine-O-phosphate; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; abstracting; addiction; anticancer agent; anticancer drug; anticancer therapy; base; biological signal transduction; c-erbB-1; c-erbB-1 Gene; c-erbB-1 Protein; c-erbB-1 Proto-Oncogenes; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cancer chemotherapy; cancer therapy; clinical investigation; cultured cell line; design; designing; drug resistant; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; facial; gatekeeper; genome mutation; hydroxyaryl protein kinase; inhibitor; inhibitor/antagonist; insight; kinase inhibitor; lung cancer; malignancy; mutant; neoplasm/cancer; new approaches; nonsmall cell lung cancer; novel; novel approaches; novel strategies; novel strategy; pathway; proto-oncogene protein c-erbB-1; prototype; public health relevance; receptor; reconstitute; reconstitution; research study; resistance mechanism; resistance to Drug; resistant; resistant mechanism; resistant to Drug; response; shRNA; short hairpin RNA; small hairpin RNA; social role; success; tumor; tyrosyl protein kinase",Circumventing Acquired Resistance to Growth Factor Receptor Kinase Inhibitors,,129933,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,367275,
7759144,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA129966-03,,NCI:508118;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","RUSSELL, STEPHEN J;",3171518;,5R01CA129966,04/11/2008,01/31/2013,"21+ years old; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; Adult; American; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibodies; Antibodies, Viral; Antibody Formation; Antibody Production; Antibody Response; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Antisera; Autologous; B blood cells; B-Cells; B-Lymphocytes; Biodistribution; Blood; Blood Circulation; Blood Plasma; Blood Plasma Cell; Blood monocyte; Bloodstream; Bone Marrow; Bone Marrow Neoplasms; Bone Marrow Tumor; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD 46 antigen; CD46; CD46 Antigen; CTX; CYCLO-cell; Cancer Drug; Cancers; Carloxan; Cells; Cessation of life; Chemotherapeutic Agents, Neoplastic Disease; Ciclofosfamida; Ciclofosfamide; Cicloxal; Circulation; Clafen; Claphene; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Complement; Complement Proteins; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytofluorometry, Flow; Cytolysis; Cytophosphan; Cytophosphane; Cytoxan; Death; Dendritic Cells; Deposit; Deposition; Dose; Early-Stage Clinical Trials; Endoxan; Endoxana; Enduxan; Exposure to; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fosfaseron; Future; Generalized Growth; Genome; Genoxal; Genuxal; Goals; Grant; Growth; Heel; Heterograft; Homing; Human; Human, Adult; Human, General; Humoral Immunities; IV drip; Immune; Immune Sera; Immunities, Humoral; Immunization, Booster; Immunization, Secondary; Immunologic, Luciferase; Infection; Intravenous; Intravenous Drip; Intravenous Infusion; Lead; Ledoxina; Luciferases; Lymph node proper; Lysis; MCP antigen; Macaca mulatta; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Measles; Measles virus; Mediating; Mice; Microfluorometry, Flow; Mitoxan; Monitor; Multiple Myeloma; Murine; Mus; Myeloma, Plasma-Cell; Neosar; Oncolytic; Patients; Pb element; Performance; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Plasma; Plasma Cells; Plasmacytes; Procytox; Production; Proliferating; Property; Property, LOINC Axis 2; Receptor Protein; Receptors, Virus; Recombinants; Refractory; Resistance; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Serum, Plasma; Rhesus; Rhesus Macaque; Rhesus Monkey; Rubeola; SCHED; SCID; SCID Mice; Schedule; Secondary Immunization; Sendoxan; Serum, Plasma; Severe Combined Immunodeficient Mice; Site; Solutions; Speed; Speed (motion); Staging; Syklofosfamid; TLX-B antigen; Testing; Therapeutic; Time; Tissue Growth; Toxic effect; Toxicities; Transgenic Organisms; Transplantation, Heterologous; Treatment Efficacy; Tumor-Specific Treatment Agents; Vaccinated; Vascular Endothelial Cell; Veiled Cells; Viral Antibodies; Viral Inactivation; Viral Receptor; Virus; Virus Inactivation; Virus Receptors; Viruses, General; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; Zytoxan; adult human (21+); antibody biosynthesis; antibody-based immunity; anticancer agent; anticancer drug; antiviral antibody; attenuated measles virus; booster vaccination; chemokine receptor; clinical investigation; combat; cytokine; design; designing; drip infusion; flow cytophotometry; gp45-70 protein; heavy metal Pb; heavy metal lead; immunoglobulin biosynthesis; improved; in vivo; intravenous administration; knock-down; lymph gland; lymph nodes; malignancy; membrane cofactor protein; monocyte; morbilli; myeloma; myelomatosis; neoplasm/cancer; neutralizing antibody; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; phase 1 study; phase 1 trial; phase I trial; plasmocyte; protein expression; protocol, phase I; receptor; receptor expression; resistant; rougeole virus; rubeola virus; severe combined immune deficiency; shRNA; short hairpin RNA; small hairpin RNA; synapse formation; synaptogenesis; therapeutic efficacy; therapeutically effective; trafficking; transgenic; tumor; tumor growth; vein infusion",Antibody Neutralization of Therapeutic Viruses,,129966,GDD,Gene and Drug Delivery Systems Study Section,,3,508118,
7754636,R01,CA,5,,02/01/2010,01/31/2011,PA-07-173,5R01CA130752-03,,NCI:309175;,2010,NATIONAL CANCER INSTITUTE,,NEW ORLEANS,UNITED STATES,PATHOLOGY,02,053785812,US,LA,70118,TULANE UNIVERSITY OF LOUISIANA,"FLEMINGTON, ERIK K;",1899536;,5R01CA130752,04/01/2008,01/31/2013,"AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Antiretroviral Therapy, Highly Active; Apoptosis; Apoptosis Pathway; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; Binding; Binding (Molecular Function); Burkitt Herpesvirus; Burkitt Lymphoma; Burkitt Lymphoma Virus; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Cancers; Carcinoma of Nasopharynx; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Proliferation; E-B Virus; EB virus; EBV; EBV latency; Environment; Epstein Barr Virus; Epstein-Barr Virus; Epstein-Barr Virus latency; Expression Profiling; Expression Signature; Functional RNA; Gene Expression; Gene Targeting; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; HAART; HHV-4; HHV-8; HHV8; Herpesviridae; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesviruses; Highly Active Antiretroviral Therapy; Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Human; Human Herpesvirus 4; Human, General; IRAK; IRAK1; IRAK1 gene; Immunoglobulin Enhancer-Binding Protein; Immunologic Deficiency Syndrome, Acquired; Individual; Infectious Mononucleosis Virus; Intracellular Communication and Signaling; KSHV; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; LMP1; Life Cycle; Life Cycle Stages; Lymphogranuloma, Malignant; Lymphoma, Non-Hodgkin's; Lymphoma, Nonhodgkins; MGC[{..}]3310; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Micro RNA; MicroRNAs; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Mutation; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; Non-Coding; Non-Coding RNA; Non-Hodgkin's Lymphoma; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Oncogenesis; Oncogenic; Patients; Play; Population; Predisposition; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteomics; Publications; Regulation; Reporter; Response Elements; Role; Scientific Publication; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Susceptibility; TNF Receptor-Associated Factor 6 Gene; TRAF6; TRAF6 gene; Targetings, Gene; Time; Transcription Factor NF-kB; Transplant Recipients; Type III Cell; Type III Epithelial Receptor Cell; UTRs; Untranslated Regions; Viral Gene Products; Viral Gene Proteins; Viral Latency; Viral Proteins; Virus; Virus Latency; Virus-HHV8; Viruses, General; anti-retroviral therapy, highly active; base; biological signal transduction; cancer cell; cultured cell line; gene product; genome mutation; herpes virus; human herpesvirus 4 group; human herpesvirus 8; in vivo; kappa B Enhancer Binding Protein; life course; lymphogranulomatosis; lymphogranulomatosis (malignant); malignancy; miRNA; molecuar profile; molecular signature; neoplasm/cancer; non-Hodgkin's lymphoma; non-Hodgkins disease; non-Hodgkins lymphoma; nuclear factor kappa beta; pelle; protein expression; response; social role; transplant patient; tumorigenesis; virus protein",Analysis of Epstein Barr virus type III latency on cellular miRNA gene expression,,130752,ZRG1,Special Emphasis Panel,,3,309175,
7763168,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA130991-03,,NCI:295065;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"FELDMAN, DAVID ;",7700928;,5R01CA130991,05/15/2008,02/28/2012,"1 alpha,25-Dihydroxycholecalciferol; 1 alpha,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D3; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-; Address; Adverse effects; Androstenedione Aromatase; Androstenedione Aromatase Inhibitor; Animal Model; Animal Models and Related Studies; Aromatase; Aromatase Cytochrome P450; Aromatase Inhibition; Aromatase Inhibitors; Athymic Nude Mouse; Attenuated; Biological; Blood Circulation; Bloodstream; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Breast; Breast Cancer Cell; Breast Cancer Treatment; COX-2 protein; COX2; COX2 enzyme; CYP 19; CYP19 Protein; CYPXIX; Calcitriol; Cancer Cell Growth; Cancer Patient; Cancer cell line; Cancer of Breast; Cancers; Catabolism; Cells; Characteristics; Circulation; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Complement; Complement Proteins; Cyclo-Oxygenase-2; Cyclooxygenase; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); Data; Development; Disease; Disorder; Dose; Down-Regulation; Down-Regulation (Physiology); Down-Regulation, Receptor; Downregulation; Drugs; Effectiveness; Enzymes; Estrogen Receptors; Estrogen Synthase; Estrogen Synthase Inhibitor; Estrogen Synthetase; Estrogen Synthetase Inhibitor; Estrogen receptor positive; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exhibits; Feedback; Gene Expression; Gene Transcription; Generalized Growth; Genes; Genetic Transcription; Genomics; Goals; Grant; Growth; Heterograft; Hormonal; Human; Human Breast Cancer Cell; Human, General; Hydroxyprostaglandin Dehydrogenases; In Vitro; Inhibition of Cell Proliferation; Investigation; Knowledge; Light; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mice; Mice, Athymic; Mice, Nude; Molecular; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; NFY factor; Negative Control of Cell Proliferation; Negative Regulation of Cell Proliferation; Nude Mice; Osteoporosis; Ovarian; P450AROM; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PTGS2; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostacyclin Dehydrogenase; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin Receptor; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; RNA Expression; Receptor Down-Regulation; Regimen; Regulation; Repression; Research Design; Role; Stimulus; Stream; Study Type; Therapeutic; Therapeutic Estrogen; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transplantation, Heterologous; Treatment Side Effects; Up-Regulation; Up-Regulation (Physiology); Upregulation; VIT D; Vitamin D; Xenograft; Xenograft procedure; Xenotransplantation; angiogenesis; bone; bone cell; cancer cell; clinical investigation; combination therapy; combined modality treatment; combined treatment; cost; cyclo-oxygenase II; cyclooxygenase 2; deprivation; disease/disorder; drug/agent; his-PG; in vivo; in vivo Model; malignancy; malignant breast neoplasm; model organism; mouse model; multimodality therapy; neoplasm/cancer; novel; nuclear factor Y; ontogeny; pathway; post-menopausal; postmenopausal; prevent; preventing; progesterone 11-hemisuccinate-(2-iodohistamine); prostaglandin H synthase-2; receptor expression; response; side effect; social role; study design; therapy adverse effect; treatment adverse effect; trial regimen; trial treatment",The Development of Vitamin D as a Therapy for Breast Cancer,,130991,CDP,Chemo/Dietary Prevention Study Section,,3,295065,
7759524,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA130995-03,,NCI:370073;,2010,NATIONAL CANCER INSTITUTE,,BUFFALO,UNITED STATES,,28,824771034,US,NY,14263,ROSWELL PARK CANCER INSTITUTE CORP,"PRUITT, STEVEN C;",1869828;,5R01CA130995,04/06/2008,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Affect; Aging; Alleles; Allelomorphs; Binding; Binding (Molecular Function); Brain; Cancer Cause; Cancer Etiology; Cancer stem cell; Cancers; Cell Cycle; Cell Cycle Arrest; Cell Division Cycle; Cells; Complex; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA replication origin; Deoxyribonucleic Acid; Dose; Dysfunction; Encephalon; Encephalons; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; First Gap Phase; Functional disorder; G1 Phase; G1 period; Gap Phase 1; Gene Expression; Gene Expression Microarray Analysis; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genome Stability; Genomic Instability; IGF1; IGF1 gene; IGFI; Licensing Factor; Location; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mediating; Mice; Molecular Interaction; Mother Cells; Murine; Mus; Muscle, Skeletal; Muscle, Voluntary; Mutation; Nervous; Nervous System, Brain; Organism; Pathway interactions; Phase; Phenotype; Physiopathology; Play; Process; Progenitor Cells; Proteins; Regulation; Replication Error; Replication Licensing; Replication Origin; Role; Senescence; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Source; Specific qualifier value; Specified; Stability, Genomic; Stem cells; TAM; Tamoxifen; Testing; Tumor Tissue; Unscheduled DNA Synthesis; age dependent; age related; basal insulin; congenic; design; designing; gene product; genome mutation; in vivo; insight; living system; malignancy; neoplasm/cancer; neural; ori Region; pathophysiology; pathway; prevent; preventing; protein complex; recombinase; relating to nervous system; response; satellite cell; senescent; social role; stem; tumor","Replication Licensing in Genome Stability, Cancer and Aging",,130995,CG,Cancer Genetics Study Section,,3,370073,
7771748,R01,CA,5,,01/19/2010,12/31/2010,PA-07-070,5R01CA131015-02,,NCI:317475;,2010,NATIONAL CANCER INSTITUTE,,DAVIS,UNITED STATES,DERMATOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"TAKADA, YOSHIKAZU ;",1891685;,5R01CA131015,03/01/2009,12/31/2012,"AFGF; Address; Affect; Antimorphic mutation; Binding; Binding (Molecular Function); Binding Sites; Body Tissues; Breast Cancer Model; Cancer of Breast; Cancers; Carcinoma, Intraductal; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell surface; Cells; Cellular Proliferation; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combining Site; Complex; Cytoplasmic Domain; Cytoplasmic Tail; DCIS; DNA Synthesis Factor; Defect; Development; Disseminated Malignant Neoplasm; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Ductal Breast Carcinoma In Situ; Ductal Carcinoma In Situ; ECGF; ECGF-alpha; ECGF-beta; ECGFA; ECGFB; Endothelial Cell Growth Factor; Endothelial Cells; Engineering; Engineerings; Event; Extracellular Matrix, Integrins; FGF; FGF-R; FGF1; FGF1 gene; FGFA; FGFR; Fibroblast Growth Factor; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Fibroblast Growth Regulatory Factor; Fibroblasts; Generalized Growth; Genetically Engineered Mouse; Goals; Growth; Growth Factor Interaction; HA copolymer; HBGF; HBGF1; Hematopoietic; Heparin; Heparinic Acid; INFLM; In Vitro; Inflammation; Integrin Binding; Integrins; Intracellular Communication and Signaling; Intraductal Carcinoma of the Breast; Isoforms; Kinetic; Kinetics; Lead; Lesion; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Glands, Human; Mammary gland; Metastatic Cancer; Metastatic Malignant Neoplasm; Mice; Mice, Transgenic; Modeling; Molecular Interaction; Molecular Weight; Morus; Morus (plant); Mulberry; Murine; Mus; Non-Infiltrating Ductal Breast Adenocarcinoma; Non-Infiltrating Ductal Carcinoma of the Breast; Non-Infiltrating Intraductal Adenocarcinoma; Non-Infiltrating Intraductal Breast Adenocarcinoma; Non-Infiltrating Intraductal Carcinoma; Non-Invasive Ductal Breast Adenocarcinoma; Non-Invasive Ductal Carcinoma of the Breast; Non-Invasive Intraductal Breast Adenocarcinoma; Noninfiltrating Intraductal Carcinoma; Oncogenesis; Pb element; Phosphorylation; Pilot Projects; Play; Pre-Malignant; Premalignant; Protein Isoforms; Protein Phosphorylation; Reactive Site; Receptors, FGF; Recruitment Activity; Relative; Relative (related person); Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stromal Cells; Testing; Therapeutic; Tissue Growth; Tissues; Transgenic Mice; Tumor Angiogenesis; Tumor Cell; Tyrosine Phosphorylation; angiogenesis; biological signal transduction; cancer progression; cell type; design; designing; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; in vivo; malignancy; malignant breast neoplasm; mammary; mammary cancer model; mammary tumor model; meetings; migration; mouse model; mutant; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new therapeutic target; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; pilot study; poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer; poly(HEMA); precancerous; public health relevance; recruit; research study; screening; screenings; social role; surface coating; tumor growth; tumor initiation; tumor progression; tumorigenesis; virtual",Potential of a dominant-negative FGF mutant as a therapeutic in cancer," We discovered that FGF1 binds to integrins, and developed a mutant of FGF1 that does not bind to integrins. We found that the mutant is not only defective in inducing signals but also suppress FGF signaling induced by wt FGF1 in a dominant-negative fashion. We will address the hypothesis that the direct binding of FGF to integrins is required for FGF signaling, and analyze the inhibitory effect of dominant-negative mutant on tumor initiation, progression, and angiogenesis in transgenic mouse model of cancer.",131015,DMP,Drug Discovery and Molecular Pharmacology Study Section,,2,317475,
7770788,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA131199-03,,NCI:327998;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GRAVES, EDWARD E;",2053290;,5R01CA131199,03/10/2008,01/31/2013,"3-Dimensional Conformal Radiation Therapy; 3D-CRT; Animal Disease Models; Animals; Animals, Laboratory; Bears; Biomedical Research; Body Tissues; Cancer Model; Cancer Radiotherapy; CancerModel; Cancers; Chemical Fractionation; Clinic; Clinical; Clinical Management; Clinical Medicine; Clinical Trials Design; Collimation; Collimator; Communities; Computer Programs; Computer software; Conformal Radiotherapy; Conformal Therapy; DNA Molecular Biology; Data; Development; Devices; Dose; Dose Fractionation; Environment; Ethics; Evaluation; Experimental Models; Experimental Models, Other; FRACN; Fractionation; Fractionation Radiotherapy; Generations; Goals; Histological Technics; Histological Techniques; Human; Human, General; Hypoxia; Hypoxic; Image; Imaging Procedures; Imaging Techniques; In Situ; Individual; Investigation; Laboratories; Laboratory Animals; Lung; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical Imaging, Positron Emission Tomography; Medical Sciences, Clinical; Methods; Methods and Techniques; Methods, Other; Mice; Modeling; Models, Experimental; Molecular Biology; Monitor; Murine; Mus; Oxygen Deficiency; PET; PET Scan; PET imaging; PETSCAN; PETT; Pancreas Cancer; Pancreas Neoplasms; Pancreatic Cancer; Pancreatic Tumor; Positron Emission Tomography Scan; Positron-Emission Tomography; Procedures; Protocol; Protocols documentation; Protocols, Treatment; Proton Magnetic Resonance Spectroscopic Imaging; RGM; Rad.-PET; Radiation; Radiation Biology; Radiation Conformal Therapy; Radiation therapy; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Radiobiology; Radiotherapeutics; Radiotherapy; Radiotherapy Dose Fractionation; Radiotherapy, Conformal; Regimen; Research; Residual; Residual state; Resistance; Respiratory System, Lung; Roentgen Rays; Scheme; Small Animal Imaging Systems; Software; Solutions; System; System, LOINC Axis 4; Technics, Histologic; Technics, Imaging; Techniques; Techniques, Histologic; Technology; Testing; Therapeutic; Tissues; Translations; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tumor of the Pancreas; Uncertainty; Ursidae; Ursidae Family; Width; X-Radiation; X-Rays; Xrays; base; clinical relevance; clinically relevant; comparative efficacy; computer program/software; cost; doubt; image guided therapy; imaging; imaging modality; improved; irradiation; malignancy; molecular imaging; neoplasm/cancer; new approaches; new technology; novel; novel approaches; novel strategies; novel strategy; pancreatic neoplasm; pulmonary; ray (radiation); resistant; response; treatment planning; tumor",Small Animal Image-Guided Radiotherapy,,131199,RTB,Radiation Therapeutics and Biology Study Section,,3,327998,
7777756,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA131218-02,,NCI:573710;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ELIASSEN, A. HEATHER ;",8696482;,5R01CA131218,03/01/2009,01/31/2013,"(3R,3'R)-beta,beta- carotene-3,3'-diol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; Active Follow-up; Active Oxygen; Address; All-Trans-Retinol; Anti-Infective vitamin; Antioxidants; Antixerophthalmic vitamin; Archives; Assay; Axerophthol; Axerophtholum; Bioassay; Biologic Assays; Biological Assay; Biosterol; Blood; Blood Plasma; Blood Sample; Blood specimen; Breast; Breast Cancer Risk Factor; Cancer Induction; Cancer of Breast; Carotene; Carotenes and Carotenoids; Carotenoids; Collection; DNA; DNA Repair Gene; Data; Deoxyribonucleic Acid; Development; Diagnosis; Dietary intake; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Estrogenic Agents; Estrogenic Compounds; Estrogens; Evaluation; Funding; GPX1 gene product; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetic analyses; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Hydroxylases; Intermediary Metabolism; Investigation; Knowledge; LUT; Lard-Factor; Leutin; Lutein; METBL; MNSOD; Malignant Tumor of the Breast; Malignant neoplasm of breast; Manganese Superoxide Dismutase; Measures; Metabolic Processes; Metabolism; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Micronutrients; Mixed Function Oxidases; Mixed Function Oxygenases; Mn Superoxide Dismutase; Mn-SOD; Monooxygenases; Nature; Neoplasm Metastasis; Nurses' Health Study; O element; O2 element; Oleovitamin A; Ophthalamin; Oxidants; Oxidative Stress; Oxidative Stress Induced Gene Expression Via Nrf2; Oxidative Stress Pathway; Oxidizing Agents; Oxygen; Oxygen Radicals; Participant; Pathway interactions; Plasma; Play; Polymorphism (Genetics); Polymorphism, Genetic; Pro-Oxidants; Process; Progesterone Receptors; Property; Property, LOINC Axis 2; Prospective Studies; Proteins; Public Health; Reactive Oxygen Species; Receptors, Progesterone; Receptors, Progestin; Reporting; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Role; SOD2; SOD2 gene; SUBGP; Sampling; Secondary Neoplasm; Secondary Tumor; Serum, Plasma; Source; Subgroup; Therapeutic Estrogen; Time; Tumor Cell Migration; Tumor Subtype; Variant; Variation; Variation (Genetics); Vitamin A Alcohol; Vitamin A USP; Woman; Work; abstracting; aged; allelic variant; anti-oxidant; beta,epsilon-Carotene-3,3'-diol, (3R,3'R,6'R)-; beta-carotene-3,3'-diol; cancer metastasis; cancer risk; carcinogenesis; cardiovascular disease risk; cardiovascular disorder risk; case control; catalase; cohort; design; designing; electron acceptor; environment effect on gene; follow-up; fruits and vegetables; gamma Lutein; gene environment interaction; gene interaction; gene product; genetic analysis; glutathione peroxidase GPX1; improved; innovate; innovation; innovative; insight; interest; malignant breast neoplasm; oxidation; oxidative damage; pathway; polymorphism; progesterone receptor; prospective; protective effect; public health medicine (field); public health relevance; retinol; social role; zeaxanthin","Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective Analysis"," Public Health Relevance Statement Oxidative stress may play an important role in the development of breast cancer through its ability to damage protein and DNA while antioxidants, from both enzymes within the body and external dietary sources, may counteract this potentially harmful pathway. This study will examine the relations of plasma markers of oxidative stress, plasma levels of carotenoids, and genetic variation in related genes with the risk of breast cancer in the prospective Nurses' Health Study cohort. Confirmation of a detrimental effect of oxidative stress and the protective benefit of carotenoids, which are amenable to dietary change, would have important public health implications.",131218,EPIC,Epidemiology of Cancer Study Section,,2,573710,
7780418,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA131301-02,,NCI:338935;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SLACK, FRANK J.;WEIDHAAS, JOANNE B (contact);",1977709;8561587 (contact);,5R01CA131301,03/05/2009,01/31/2014,"Adenoviral Vector; Adenovirus Vector; Animals; C elegans; C-K-RAS; C.elegans; Caenorhabditis elegans; Cancer Cause; Cancer Etiology; Cancer Genes; Cancer Patient; Cancer Radiotherapy; Cancer Treatment; Cancer cell line; Cancer of Lung; Cancer-Promoting Gene; Cancers; Cell Death; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Survival; Cell Viability; Cell division; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Proliferation; Cessation of life; Clinical; Cytotoxic Chemotherapy; Cytotoxic Therapy; DNA Damage; DNA Injury; Data; Death; Defect; Development; Disease; Disorder; Enhancers; Family; Future; Gametes; Gene Targeting; Generalized Growth; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Germ Cells; Germ-Line Cells; Growth; Heterograft; Human; Human, General; Hyperplasia; Hyperplastic; In Vitro; Intervention; Intervention Strategies; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Lead; Learning; Light; Lung; Lung Neoplasms; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Transgenic; Micro RNA; MicroRNAs; Modeling; Murine; Mus; Mutation; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenes; Oncogenic; Outcome; Pathway interactions; Pb element; Photoradiation; Pulmonary Cancer; Pulmonary Neoplasms; Pulmonary malignant Neoplasm; RASK2; Radiation; Radiation therapy; Radiotherapeutics; Radiotherapy; Regulation; Regulator Genes; Reproductive Cells; Research; Respiratory System, Lung; Sex Cell; Subcellular Process; Targetings, Gene; Testing; Tissue Growth; Toxic effect; Toxicities; Transcriptional Regulatory Elements; Transforming Genes; Transgenic Mice; Translating; Translatings; Transplantation, Heterologous; Tumor Suppressor Proteins; Tumor of the Lung; Work; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; adeno vector; adenovector; anticancer research; anticancer therapy; base; biomarker; cancer cell; cancer research; cancer therapy; cell growth; chemotherapy; disease/disorder; effective therapy; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; initial cell; interventional strategy; irradiation; language translation; lung cancer; malignancy; member; miRNA; mouse model; mutant mouse model; necrocytosis; neoplasm/cancer; novel; ontogeny; overexpression; pathway; prevent; preventing; public health relevance; pulmonary; ray (radiation); regulatory gene; research study; response; sexual cell; success; trans acting element; tumor suppressor; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog",Let-7 microRNAs in Lung Cancer: Altering Growth and Radioresistance, Project Narrative  Understanding the potential of microRNAs (recently discovered genetic regulators) as novel cancer therapies themselves or as enhancers of current cancer therapies would be an enormous advance in cancer research. In this proposal we plan experiments to learn how to harness these natural genetic growth repressors to work towards their application to cancer therapy.,131301,RTB,Radiation Therapeutics and Biology Study Section,,2,338935,
7777342,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA131332-02,,NCI:558220;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"TAMIMI, RULLA M;",6428057;,5R01CA131332,03/01/2009,07/31/2012,"Affect; BMI percentile; BMI z-score; Biological; Biology; Blood Sample; Blood specimen; Body mass index; Breast; Breast Cancer Prevention; Breast Cancer Risk Factor; Cancer Induction; Cancer of Breast; Cancer of Prostate; Causality; Chemotherapy-Hormones/Steroids; Chronic Disease; Chronic Illness; Complement; Complement Proteins; Complex; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Data; Diet; Disease; Disorder; Endocrine Gland Secretion; Environmental Factor; Environmental Risk Factor; Etiology; GWAS; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Markers; Genetic Variation; Genome Scan; Genotype; Health; Hereditary; Heritability; Heritable Quantitative Trait; Hormones; Inherited; Intervention; Intervention Strategies; Lead; Life; Lifestyle Factors, Unspecified; Lipids; MMG; Malignant Tumor of the Breast; Malignant Tumor of the Prostate; Malignant neoplasm of breast; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammogram; Mammographic Density; Mammography; Markers, Surrogate; Measures; Nurses' Health Study; Outcome; Participant; Pathway interactions; Pb element; Phenotype; Population; Position; Positioning Attribute; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Predisposition; Prevention; Prostate CA; Prostate Cancer; Prostatic Cancer; Quantitative Trait, Heritable; Quetelet index; Risk; Risk Factors; Staging; Surrogate Markers; Susceptibility; Therapeutic Hormone; Variant; Variation; Variation (Genetics); Woman; allelic variant; biomarker; breast density; cancer genetics; cancer genome; cancer risk; carcinogenesis; case control; chronic disease/disorder; chronic disorder; cohort; cost; density; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environment effect on gene; environmental risk; gene environment interaction; gene interaction; genetic variant; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; interventional strategy; lifestyle factors; malignant breast neoplasm; mammary cancer prevention; mammary tumor prevention; non-genetic; novel; pathway; post-menopausal; postmenopausal; public health relevance; reproductive; trait; whole genome association studies; whole genome association study",Whole Genome Association Study of Mammographic Density," Project Narrative Elucidating the genetic components of complex diseases with multifactorial causes such as breast cancer can be enhanced through concentration on heritable risk factors for the disease. Mammographic density is a highly heritable, reliably measured, quantitative trait and a well- established strong predictor of breast cancer independent of known breast cancer risk factors. This multi-stage genome-wide association study of mammographic density will not only identify novel loci associated with breast density, but will complement the studies of breast cancer by increasing our understanding of breast biology and etiology of breast cancer. ______________________________________________________________________________________ PHS 398/2590 (Rev. 09/04) Page______ Continuation Format Page",131332,EPIC,Epidemiology of Cancer Study Section,,2,558220,
7758841,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA131402-03,,NCI:274523;,2010,NATIONAL CANCER INSTITUTE,,AUGUSTA,UNITED STATES,BIOCHEMISTRY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"THANGARAJU, MUTHUSAMY ;",8907535;,5R01CA131402,04/17/2008,01/31/2013,"4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5-AC; 5-Aza-cytidine; 5-Azacytidine; AZC; Activation, Gene; Animal Model; Animal Models and Related Studies; Anti-Estrogens; Apoptosis; Apoptosis Pathway; Apoptotic; Athymic Nude Mouse; Azacitidine; Azacytidine; Biological Models; Body Tissues; Breast; Breast Cancer Cell; Breast Cancer Treatment; Breast Neoplasms; Breast Tumors; Butyrates; C-EBP Nuclear Protein; C-EBP Proteins; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; Cancer Treatment; Cancer cell line; Cancer of Breast; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Function; Cell Line, Tumor; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Transformation; Cessation of life; Cola; Colon; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combined Modality Therapy; Cytoplasmic Membrane; DNA; DNA (Cytosine-5-)-Methyltransferase 3 Beta Gene; DNA MTase HsaIIIB Gene; DNA Methylation; DNA Methyltransferase; DNA Methyltransferase 3B Gene; DNA Methyltransferase HsaIIIB Gene; DNA Modification Methylases; DNA Modification Methyltransferases; DNA-Methyltransferases; DNMT3B gene; DNMT3b; Data; Death; Deoxyribonucleic Acid; Development; Dietary Fiber; Disease; Disorder; Dnmt; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2; EC 2.1.1.113; Epithelial Cells; Estrogen Antagonists; Estrogen Receptors; Estrogen Therapy; Estrogen receptor negative; Estrogen receptor positive; Event; Fatty Acids, Short-Chain; Fatty Acids, Volatile; Fermentation; Gene Activation; Generalized Growth; Genes; Genes, p53; Genus Cola; Growth; HDAC Agent; Heterograft; Histone Deacetylase Inhibitor; Histone deacetylase inhibition; Histones; Human; Human Breast Cancer Cell; Human, General; Hypermethylation; ICF Gene; Induction of Apoptosis; Intracellular Communication and Signaling; Killings; Knock-out; Knockout; Knockout Mice; Laboratories; Lead; Link; M.HsaIIIB Gene; MAPK Signaling Pathway; MAPK Signaling Pathway Pathway; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; MDA MB 231; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary Tumorigenesis; Mammary gland; Man (Taxonomy); Man, Modern; Mediating; Membrane Transport Proteins; Membrane Transporters; Methylation; Mice; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Mice, Transgenic; Model System; Models, Biologic; Modification Methylases; Molecular; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; New Agents; Nude Mice; Null Mouse; Oncogene Activation; Oncogenesis; Oncogenic; P53; Patients; Pb element; Plasma Membrane; Play; Prevention; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Propionates; Protein Methylation; Proteins; Pyruvate; Pyruvates; RAS Family Oncogene; RNA, Small Interfering; Receptor Signaling; Recurrence; Recurrent; Research Design; Retrovirus Associated Sequence Oncogene; Role; Secondary to; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site-Specific DNA-methyltransferase; Small Interfering RNA; Study Type; Subcellular Process; TP53; TP53 gene; TRP53; Testing; Tet; Tetanus Helper Peptide; Therapeutic; Tissue Growth; Tissues; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transferase; Transgenic Mice; Transplantation, Heterologous; Tumor Cell; Tumor Cell Line; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Volatile Fatty Acids; WAP; Whey Acidic Protein; Whey Acidic Protein Staining Method; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; anticancer therapy; antiestrogen; antiestrogenic; apical membrane; base; biological signal transduction; cancer cell; cancer progression; cancer therapy; cell growth; combination therapy; combined modality treatment; combined treatment; design; designing; disease/disorder; effective therapy; estrogen inhibitor; gene product; heavy metal Pb; heavy metal lead; homologous recombination; in vivo; inhibitor; inhibitor/antagonist; ladakamycin; loss of function; malignant breast neoplasm; mammary; mammary tumor; metaplastic cell transformation; model organism; multimodality therapy; necrocytosis; neoplasm progression; neoplastic cell; neoplastic progression; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; plasmalemma; protein function; ras Oncogene; siRNA; social role; stable cell line; study design; therapeutic development; tumor; tumor progression; tumor suppressor; tumorigenesis; tumorigenic; whey acidic proteins; whole grain",Tumor-Suppressive Function of SLC5A8 in Mammary Gland and its Relevance to Breast,,131402,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,274523,
7760543,R01,CA,5,,01/27/2010,12/31/2010,PAR-07-270,5R01CA132091-03,,NCI:275202;,2010,NATIONAL CANCER INSTITUTE,,WYNNEWOOD,UNITED STATES,,06,125797084,US,PA,19096,LANKENAU INSTITUTE FOR MEDICAL RESEARCH,"SAWICKI, JANET A.;",1868530;,5R01CA132091,02/01/2008,12/31/2012,"2-propenoic acid; Address; Affinity; Animal Welfare; Antibody Fragments; Assay; Attention; Bibliography; Bioassay; Bioavailability; Biodistribution; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Bioluminescence; Blood; Blood Serum; Cancer Patient; Cancer of the Ovary; Cancers; Carcinoma of Ovary; Cell model; Cells; Cellular model; Chemicals; Communities; Complex; Country; DNA; DNA delivery; Debulking; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disorder; Drug Formulations; Ecological impact; Effectiveness; Environment; Environmental Impact; Equipment; Esters; Ethics Committees, Research; Folic Acid; Formulation; Formulations, Drug; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes, Reporter; Genetic Intervention; Genital System, Female, Ovary; Goals; Human; Human, General; IACUC; IRBs; Image; Imaging technology; Immunoglobulin Fragments; Immunologic, Luciferase; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention, Genetic; Lead; Length of Life; Life; Light; Literature; Longevity; Luciferases; Malignant Cell; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Mammals, Mice; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Modality; Modification; Molecular Biology, Gene Therapy; Muellerian inhibiting hormone; Mullerian-inhibiting factor; Murine; Mus; N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; Names; Nature; Neoplasm Metastasis; Non-Viral Vector; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Ovarian; Ovarian Carcinoma; Ovarian Tumor; Ovary; Ovary Neoplasms; Pathology; Patients; Pb element; Photoradiation; Physiologic Availability; Platinum; Platinum Black; Polymers; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pt element; Pteroylglutamic Acid; Receptor Protein; Recurrent disease; Regimen; Relapsed Disease; Reporter Genes; Research; Research Ethics Committees; Research Resources; Resistance; Resources; Reticuloendothelial System, Blood; Screening procedure; Secondary Neoplasm; Secondary Tumor; Serum; Soluble Mpf/Mesothelin-Related Protein; Specificity; Spinal Column; Spine; Staging; Structure; Surface; Surgical; Surgical Interventions; Surgical Procedure; Survival Rate; Testing; Therapeutic; Therapy, DNA; Time; Toxic effect; Toxicities; Transfection; Transgenic Model; Treatment Efficacy; Tumor Cell; Tumor Cell Migration; Tumor Debulking; Tumor of the Ovary; United States; Variant; Variation; Vertebral column; Vertebrate Animals; Vertebrates; Viral Vector; Vitamin M; Woman; Xenograft Model; abstracting; acrylic acid; anti-mullerian factor; anti-mullerian hormone; antimullerian hormone; backbone; base; bioavailability of drug; cancer cell; cancer metastasis; cancer type; cell killing; chemotherapy; combinatorial; design; designing; disease/disorder; effective therapy; expectation; experiment; experimental research; experimental study; expiration; gene product; gene therapy; genetic therapy; heavy metal Pb; heavy metal lead; human subject; imaging; immunogenicity; improved; in vivo; innovate; innovation; innovative; intraperitoneal; life span; lifespan; malignancy; megakaryocyte potentiating factor; mesothelin; mouse model; mullerian inhibiting substance; mullerian regression factor; mullerian-inhibiting hormone; mullerian-inhibitory substance; nano particle; nano therapy; nanoparticle; nanotherapy; neoplasm/cancer; neoplastic cell; ovarian cancer; ovarian neoplasm; programs; receptor; research study; resistant; response; screening; screenings; site targeted delivery; standard care; suicide gene; surgery; targeted delivery; therapeutic efficacy; therapeutic gene; therapeutically effective; tumor; vertebrata; vitamin Bc",Targeted Nanoparticle DNA Therapy for Ovarian Cancer,,132091,ZRG1,Special Emphasis Panel,,3,275202,
7752586,R01,CA,5,,02/01/2010,01/31/2011,PA-07-173,5R01CA132637-03,,NCI:308138;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,PEDIATRICS,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"GAO, SHOU-JIANG ;",7678925;,5R01CA132637,04/01/2008,01/31/2013,"AIDS; ANGPT2; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Activator Protein-1; Ang-2; Ang2; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibition; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Angiogenesis Modulators; Angiogenesis Pathway; Angiogenetic Antagonists; Angiogenic Antagonists; Angiogenic Factor; Angiogenic Inhibition; Angiopoietin-2; Angiostatic Agents; Animal Model; Animal Models and Related Studies; Animals; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Assay; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bioassay; Biologic Assays; Biological Assay; Blood Vessel Tumor; Body Tissues; CLG; Cancer Treatment; Cancers; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; Cellular Proliferation; Complex; Development; Differentiation Factor, B-Cell; Disease; Disorder; Drugs; EC 2.7.2-; Endothelial Cells; Enhancer-Binding Protein AP1; Extracellular Signal-Regulated Kinases; Factor, Angiogenesis; Fibroblast Collagenase; Gene Expression; Generalized Growth; Genes; Genes, Viral; Genome; Goals; Growth; HHV-8; HHV8; HPGF; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IHC; IL-6; IL6 Protein; INFLM; Image; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; In element; Indium; Individual; Infection; Infiltration; Inflammation; Inflammatory; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Interstitial Collagenase; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Knock-out; Knockout; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MEKs; MGI-2; MMP-1; MMP-1Fibroblast Collagenase; MMP1; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maps; Matrix Metalloproteinase-1; Mediating; Medication; Mitogen-Activated Protein Kinases; Modeling; Molecular; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multiple Hemorrhagic Sarcoma; Myeloid Differentiation-Inducing Protein; Neoplasms in Vascular Tissue; Neovascularization Inhibitors; ORFs; Oncogenesis; Open Reading Frames; Oral; Pathogenesis; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmacytoma Growth Factor; Play; Prevention; Preventive; Process; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Coding Region; Recombinants; Regulation; Repression; Research; Role; Societies; Spindle Endothelial Cell; Staging; System; System, LOINC Axis 4; Testing; Therapeutic; Time; Tissue Growth; Tissues; Transcription Factor AP-1; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tumor Angiogenesis; Umbilical vein; VEGF, Hypoxia, and Angiogenesis; Vascular Neoplasms; Vascular Tissue Tumor; Vascular Tumor; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Genome; Viral Proteins; Virus Diseases; Virus-HHV8; Work; angiogenesis; antiangiogenic; anticancer therapy; base; blood vessel neoplasm; cancer therapy; cellular targeting; disease/disorder; drug/agent; expectation; human herpesvirus 8; imaging; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; interdisciplinary approach; interferon beta 2; malignancy; model organism; mutant; neoplasm/cancer; novel; ontogeny; paracrine; pathway; programs; reconstitute; reconstitution; social role; therapeutic target; tumor; tumor growth; tumorigenesis; viral infection; virus infection; virus protein",Mechanism of KSHV-induced angiogenesis,,132637,ZRG1,Special Emphasis Panel,,3,308138,
7767731,R01,CA,5,,02/01/2010,01/31/2011,PAR-07-344,5R01CA132744-02,,NCI:710952;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"SANDER, CHRIS ;",3131730;,5R01CA132744,04/01/2009,01/31/2013,"3-D structure; 3-dimensional structure; 3D structure; Access to Information; Accounting; Algorithms; Allelic Loss; Amino Acid Substitution; Amino Acids; Animal Experiments; Atlases; Automobile Driving; Bears; Biochemical; Biological; Breast; Cancer Genes; Cancer Treatment; Cancer of Breast; Cancer-Promoting Gene; Cancers; Carcinoma, Non-Small-Cell Lung; Cells; Characteristics; Clinical; Cola; Collaborations; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combined Modality Therapy; Communication; Communities; Computational Biology; Computational algorithm; Computer Analysis; Computer Programs; Computer software; Computing Methodologies; Cosmic; DNA Resequencing; DNA copy number; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Development; Diagnosis; Diagnostic; Disease; Disorder; Drivings, Automobile; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Evolution; Experiments, Animal; Family; Forecast of outcome; Fostering; Funding; Future; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Variation; Genetic defect; Genomics; Genotype; Genus Cola; Goals; H-ras; H-ras Gene; H-ras Oncogene; HER1; HRAS; HRAS gene; HRAS1; Hand; Harvey Rat Sarcoma Viral Oncogene Homolog; Human; Human, General; IT Systems; Individual; Information Resources; Information Systems; Information Technology Systems; Institutes; Institution; Internet; Investigators; Knowledge; Laboratories; Lead; Link; Loss of Heterozygosity; MSKCC; Macromolecular Structure; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Maps; Medication; Memorial Sloan-Kettering Cancer Center; Methods; Molecular; Molecular Genetic; Molecular Genetics; Molecular Structure; Motivation; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Mutate; Mutation; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Oncogenes; Oncogenesis; Oncogenic; Participant; Pathway interactions; Patients; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pilot Projects; Point Mutation; Predisposition; Preparation; Process; Prognosis; Protein Family; Proteins; RAS Gene; RASH1; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Relative; Relative (related person); Reporting; Research; Research Personnel; Research Resources; Researchers; Resequencing; Resources; Role; Sampling; Software; Structure; Susceptibility; Systems, Data; Technology; Testing; Therapeutic; Time; Transforming Genes; Transforming Growth Factor alpha Receptor; Translating; Translatings; Tumor Subtype; Ursidae; Ursidae Family; Validation; Variation (Genetics); WWW; Work; allelic variant; aminoacid; anticancer research; anticancer therapy; base; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer classification; cancer genetics; cancer genome; cancer genomics; cancer research; cancer therapy; cancer type; clinical data repository; clinical data warehouse; clinical practice; combination therapy; combined modality treatment; combined treatment; computational analysis; computational methodology; computational methods; computational tools; computer methods; computer program/software; computerized tools; computing resources; cost; data repository; develop software; developing computer software; disease-causing mutation; disease/disorder; driving; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gain of function; gene function; gene product; genome database; genome mutation; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; knowledge resource; language translation; loss of function; malignancy; malignant breast neoplasm; meetings; multimodality therapy; neoplasm/cancer; next generation; nonsmall cell lung cancer; novel; outcome forecast; outreach to information; pathway; pilot study; prognostic; protein complex; protein function; protein structure; proto-oncogene protein c-erbB-1; relational database; research study; social role; software development; therapeutic target; three dimensional structure; tool; tumor; tumorigenesis; v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog; web; web-accessible; world wide web",Functional consequences of cancer mutations," In synergy with large scale cancer genomics projects we plan to elucidate the role of thousands of protein mutations observed in many human tumor samples. The Online Mutation Assessor (OMA), a computational resource, will combine detailed knowledge about the evolution and structure of proteins and their interactions in biomolecular pathways and provide researchers with an estimate of the functional impact of protein mutations observed in individual patients. When translated to clinical practice, detailed knowledge about an individual's mutation profile will enable a more personalized approach to cancer therapy.",132744,BDMA,Biodata Management and Analysis Study Section,,2,710952,
7759540,R01,CA,5,,01/01/2010,12/31/2010,PA-07-070,5R01CA132831-03,,NCI:312288;,2010,NATIONAL CANCER INSTITUTE,,SALT LAKE CITY,UNITED STATES,BIOMEDICAL ENGINEERING,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"KOPECEK, JINDRICH H.;",1867678;,5R01CA132831,04/01/2008,12/31/2012,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 1,2-Ethanediol; 12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; 12-O-tetradecanoylphorbol-13-acetate; 14-Hydroxydaunomycin; 2,2'-azobis(2-methylpropionitrile); 2,2'-azobisisobutyronitrile; 2,5-Pyrrolidinedione, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis-; 2-Hydroxyethanol; 3,3'-dithiobis(propionic acid hydroxysuccinimide ester); 3,3'-dithiodipropionic acid disuccinimide ester; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 5-Isothiocyanatofluorescein; 6-(3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthalenecarboxylic acid; 9-cis-Retinoic Acid Receptor; AHPN; AIBN; Abbreviations; Acetates; Acids; Address; Adriamycine; Alanine; Alanine, L-Isomer; American; American Cancer Society; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibodies; Antigen Targeting; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Anzatax; Apoptosis; Apoptosis Pathway; Apoptosis Promoter; Asotax; BODIPY; Benzoates; Binding; Binding (Molecular Function); Blood Circulation; Bloodstream; Body Tissues; Bristaxol; C 3-5 Converting Enzyme; C3 Proactivator; C3PA; CVFBb; CYP; Cancer Cause; Cancer Drug; Cancer Etiology; Cancer Treatment; Cancer of Prostate; Cell Death, Programmed; Cell Survival; Cell Viability; Cell-Death Protease; Cessation of life; Chemotherapeutic Agents, Neoplastic Disease; Chromatography, Molecular Sieve; Circulation; Clathrin; Clinical Data; Complement 3 Proactivator; Complement Factor B; Complement Factor B, Alternative Pathway; Complement Protein B; Complement Protein Factor B; Cyclohexanamine, N,N'-methanetetraylbis-; Cytochromes; DCCD; DMSO; DNA Fragmentation; DNA Molecular Biology; DOX; DSP cross linker; DTBSP; Death; Demasorb; Demeso; Dicyclohexylcarbodiimide; Dihydroxyethanes; Dimethyl Sulfoxide; Dimethylsulphinyl; Dimethylsulphoxide; Domoso; Doxorubicin; Doxorubicina; Dromisol; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; EC 3.4.21.34; Endocytosis; Esters; Ethanediols; Ethylene Glycols; Evaluation; FITC; FOLH1 Protein; FPLC; FRET; Factor B; Fast Protein Liquid Chromatography, TM Pharmacia; Fletcher Factor; Fluorescein; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescence Resonance Energy Transfer; Folate Hydrolase 1; Folate Hydrolase I; Formulation; Formulations, Drug; Furans; GFP; Glucocorticoid Receptor; Glutamate Carboxypeptidase II; Glycolates; Granulocyte/Pollen-Binding Protein; Green Fluorescent Proteins; Guanidine Monohydrochloride; Guanidinium Chloride; Guanidium Chloride; HRP; Horseradish Peroxidase; Human; Human, General; Hydrochloride, Guanidine; Hydrogen Oxide; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; ICE-like protease; In Vitro; Individual; Inducer of Apoptosis; Induction of Apoptosis; Isothiocyanates; J591; J591 Monoclonal Antibody; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; KLK3; Kallikrein 3; L-Alanine; L-Tryptophan; Lactic acid; Lead; Levotryptophan; Libraries; Liquid substance; MAP Kinase 8; MAP Kinase 8 Gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MAb J591; MOMP; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Mediating; Medication; Methods; Mitochondria; Mitogen-Activated Protein Kinase 8; Moab, Clinical Treatment; Modality; Molecular Biology; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Sieve Chromatography; Molecular Stereochemistry; Molecular Weight; Monoclonal Antibodies; Monoethylene Glycol; N,N-diethylethanamine; N-Acetylaspartylglutamate Peptidase; N-Acetylated-alpha-Linked Acidic Dipeptidase; N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; NAAG Peptidase; NAALADase; NAALADase II; NAALADase L; NR0B2 protein; Names; Non-Essential Amino Acid; Nonessential Amino Acid; Nuclear; Nuclear Orphan Receptor; Outer Mitochondrial Membrane; P-30 Antigen; PMA; PMAS; PRKM8; PSMA; Paclitaxel; Paclitaxel (Taxol); Pb element; Peptide Synthesis; Peptides; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phorbol Myristate Acetate; Phosphate Buffer; Pinocytosis; Plasma Kallikrein Precursor; Plasma Prekallikrein; Polymers; Praxel; Problem Solving; Properdin Factor B; Prostate CA; Prostate Cancer; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostate-Specific Membrane Antigen; Prostatic Cancer; RXR; RXR Protein; RXR alpha Receptor; RXRA; Randomized; Receptor Protein; Regimen; Retinoic Acid Receptor RXR; Retinoic Acid Receptor RXR-Alpha; Retinoid X Receptor A; Retinoid X Receptor alpha; Retinoid X Receptors; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SHP protein; SOS; SOS Proteins; SOS exchange factor; SPPS; Saline; Saline Solution; Scanning; Science; Semenogelase; Seminin; Siderophilin; Site; Size Exclusion Chromatography; Solid; Son of Sevenless Proteins; Specificity; Spinal Column; Spine; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Structure; Sulfinylbis(methane); TLC; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Taxotere; Temperature; Tetradecanoylphorbol Acetate; Therapeutic; Therapeutic Agents; Therapeutic Androgen; Therapeutic Index; Therapeutic Uses; Thin Layer Chromatography; Thiones; Thiophenes; Tissues; Toxic effect; Toxicities; Transferrin; Transferrin Receptor; Tryptophan; Tumor-Specific Treatment Agents; Tweens; Vertebral column; Water; abstracting; analog; androgen independent prostate cancer; animal data; anticancer agent; anticancer drug; anticancer therapy; antigen binding; azobis(isobutyronitrile); azobisisobutyronitrile; backbone; base; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cancer cell; cancer diagnosis; cancer therapy; caspase; chemotherapy; cinnamic acid; combinatorial; combinatorial chemistry; conformation; conformational state; copolymer; cystein protease; cystein proteinase; cysteine endopeptidase; design; designing; dithio bis(succinimidyl propionate); dithiobis((succinimidyl)propionate); dithiobis(succinimidylpropionate); docetaxel; docetaxol; drug/agent; efficacy evaluation; ethylene glycol; fast protein liquid chromatography; fluid; formamide; gamma-Seminoprotein; hK3 Kallikrein; heavy metal Pb; heavy metal lead; immunogenicity; improved; in vivo; indexing; innovate; innovation; innovative; interdisciplinary approach; jun-NH2-Terminal Kinase; kininogenin; liquid; macromolecule; major outer membrane protein; member; men; men's; methacrylamide; mitochondrial; mouse model; nano sized; nanosized; new therapeutics; next generation therapeutics; novel; novel therapeutics; phenylisoserine; protein expression; randomisation; randomization; randomly assigned; receptor; receptor mediated endocytosis; small heterodimer partner; small heterodimer partner protein; son of sevenless protein; stable plasma protein solution; stress-activated protein kinase 1; synergism; triethylamine; tumor; uptake",DOUBLE-TARGETED MACROMOLECULAR THERAPEUTICS FOR THE TREATMENT OF PROSTATE CANCER,,132831,BMBI,Biomaterials and Biointerfaces Study Section,,3,312288,
7759212,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA132853-03,,NCI:260620;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,BIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"LAKKA, SAJANI ;",9092205;,5R01CA132853,04/01/2008,01/31/2013,"0-11 years old; Abscission; Adenoviridae; Adenoviruses; Adhesions; Adhesives; Affect; Animals; Apoptosis; Apoptosis Pathway; Athymic Nude Mouse; BM 40 Protein; BM-40; Basement Membrane Tumor Protein; Biological; Blood Vessels; Body Tissues; Brain; Cancer Radiotherapy; Cancer of Brain; Cancer of Lung; Cancer of the Ovary; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Central Nervous System; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Complementary DNA; Cysteine; DNA, Complementary; Data; Deposit; Deposition; Development; Diagnosis; DsRed; ECM; Encephalon; Encephalons; Excision; Exhibits; Extirpation; Extracellular Matrix; Family; Forecast of outcome; Gastrointestinal Tract, Pancreas; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generalized Growth; Genetic Intervention; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; Glycoproteins; Goals; Growth; Half-Cystine; Heterograft; Human; Human, Child; Human, General; Image; Implant; In Vitro; Infection; Intervention, Genetic; Intracellular Communication and Signaling; Investigation; L-Cysteine; LTS; Length; Long-Term Survivors; Malignant; Malignant - descriptor; Malignant Cell; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Pancreatic Neoplasm; Malignant Tumor of the Brain; Malignant Tumor of the Lung; Malignant Tumor of the Ovary; Malignant neoplasm of brain; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Man (Taxonomy); Man, Modern; Mediating; Methods; Mice, Athymic; Mice, Nude; Modality; Modeling; Molecular; Molecular Biology, Gene Therapy; Neoplasms of Neuroglia; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neuroglial Neoplasm; Neuroglial Tumor; Normal Cell; Nude Mice; Oncogenesis; Operation; Operative Procedures; Operative Surgical Procedures; Osteonectin; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pathway interactions; Patients; Post-Operative; Postoperative; Postoperative Period; Prognosis; Proteins; Pulmonary Cancer; Pulmonary malignant Neoplasm; Radiation; Radiation Sensitivity; Radiation Tolerance; Radiation therapy; Radiosensitivity; Radiotherapeutics; Radiotherapy; Regulation; Relative; Relative (related person); Removal; Role; SPARC Glycoprotein; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Staining method; Stainings; Stains; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Survivors, Long-Term; Therapeutic; Therapeutic Effect; Therapy, DNA; Tissue Growth; Tissues; Transplantation, Heterologous; Tumor Angiogenesis; Tumor Cell; Tumor Tissue; Tumors of Neuroglia; Xenograft; Xenograft procedure; Xenotransplantation; angiogenesis; base; biological signal transduction; cDNA; cancer cell; cell growth; children; clinical investigation; extracellular; gene product; gene therapy; genetic therapy; imaging; improved; in vivo; irradiation; lung cancer; medulloblastoma; medulloblastoma cell line; migration; neoplastic cell; novel therapeutic intervention; ontogeny; outcome forecast; ovarian cancer; overexpression; pathway; pre-clinical; preclinical; ray (radiation); resection; social role; surgery; treatment effect; tumor; tumor growth; tumor xenograft; tumorigenesis; vascular; vector; vector control; youngster",Regulation of medulloblastoma tumor growth by SPARC,,132853,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,3,260620,
7759525,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA132878-03,,NCI:313533;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","MER, GEORGES ;",7859171;,5R01CA132878,04/01/2008,01/31/2013,"3-D structure; 3-dimensional structure; 3D structure; 53BP1 protein, human; ATGN; Acetylation; Affinity; Antigens; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; BRCT Domain; Binding; Binding (Molecular Function); Breast Cancer Carboxy-Terminal Domain; Cancer Treatment; Cancer of Brain; Cancers; Cell Communication and Signaling; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Tumor Antigen P53; Collaborations; Complex; Coupling; DNA; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Repair; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; DNA repair protein; Data; Deoxyribonucleic Acid; Disulfides; Double Strand Break Repair; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Eukaryota; Eukaryote; Fission Yeast; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome Stability; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioma; H2A Histone Family, Member X; H2A histone family, member X protein, human; H2A.X protein, human; H2A/X; H2AFX; H2AFX protein, human; H2AX; H2AX protein, human; Histone Acetylase; Histone H2A.X; Histone H2AX; Histone H3; Histone H4; Histones; Human; Human, General; Hybrids; In Vitro; Intracellular Communication and Signaling; Knowledge; L-Lysine; L-Serine; Light; Link; Lysine; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Brain; Malignant neoplasm of brain; Man (Taxonomy); Man, Modern; Methylation; Modification; Molecular Interaction; Molecular Probes; Mutation; NMR Spectroscopy; Neoplasms of Neuroglia; Neuroglial Neoplasm; Neuroglial Tumor; Nuclear Magnetic Resonance; Oncoprotein p53; Organism; Ortholog; Orthologous Gene; P53; Peptides; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Photoradiation; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prevention; Process; Protein Methylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein TP53; Protein p53; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Public Health; Recruitment Activity; Regulation; Research; Role; S pombe; Schizosaccharomyces pombe; Series; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Spectroscopy, NMR; Stability, Genomic; Structure; Subcellular Process; TP53; TP53 gene; TP53BP1 protein, human; TRP53; Testing; Time; Transducers; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Tumors of Neuroglia; Unscheduled DNA Synthesis; Work; Yeast, Fission; anticancer therapy; base; biological signal transduction; cancer therapy; cross-link; crosslink; design; designing; dimer; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; histone acetyltransferase; human 53BP1 protein; human H2AX protein; immunogen; in vivo; living system; malignancy; neoplasm/cancer; neoplastic cell; nuclear magnetic resonance spectroscopy; p202 protein, human; p53 Antigen; p53 Tumor Suppressor; p53-binding protein 1; p53-binding protein 1, human; prevent; preventing; public health medicine (field); recruit; repair; repaired; research study; response; social role; structural biology; three dimensional structure; tumor protein p53 binding protein, 1, human; tumor suppressor",Structural Biology of Lysine Methylation in DNA Damage and Checkpoint Signaling,,132878,MSFC,Macromolecular Structure and Function C Study Section,,3,313533,
7795777,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA132935-02,,NCI:671363;,2010,NATIONAL CANCER INSTITUTE,,WORCESTER,UNITED STATES,FAMILY MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"COSTANZA, MARY E;LUCKMANN, ROGER S (contact);",1888012;1965673 (contact);,5R01CA132935,03/27/2009,01/31/2014,"Address; Adherence; Adherence (attribute); Adopted; Adoption; Affect; Age; Arm; Behavioral; Booklets; Breast; Breast Cancer Detection; Breast cancer screening; Brochures; Cancer of Breast; Care, Health; Care, Managed; Caring; Censuses; Commit; Community Health Planning; Counseling; Data; Decision Making; Delivery of Health Care; Drops; Economic Income; Economical Income; Education; Educational aspects; Effectiveness; Effectiveness of Interventions; Effects, Longterm; Enrollment; Evaluation; Guidelines; Health; Health Planning; Health Sciences, Allied and Health Services Delivery; Healthcare; Healthcare Delivery; High Prevalence; Income; Insurance; Intervention; Intervention Strategies; Letters; Long-Term Effects; MMG; Mails; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammogram; Mammography; Managed Care; Modeling; Mortality; Mortality Vital Statistics; Motivation; Outcome; Pamphlets; Patients; Phone; Plannings, Community Health; Population; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Randomized; Research; Risk; Role; SCHED; SUBGP; Schedule; Screening procedure; Source; Staging; Subgroup; System; System, LOINC Axis 4; Telephone; Testing; Time; Triage; Uncertainty; Upper arm; Woman; aged; base; compare effectiveness; computer-based representation; computerized; cost; cost effective; cost effectiveness; doubt; effect of intervention; enroll; frame-based representation; health care delivery; health care organization; health care service organization; improved; information organization; interventional strategy; knowledge representation; malignant breast neoplasm; mammary cancer detection; member; motivational enhancement therapy; motivational interview; outreach; outreach program; programs; public health relevance; randomisation; randomization; randomly assigned; response; screening; screenings; social role; successful intervention; treatment as usual",Promoting Breast Cancer Screening in Non-Adherent Women, 7. Project Narrative Research has shown that mailing reminders and calling women who are due for a screening mammogram can increase the chances that these women will get a mammogram. Research is needed to identify the most effective and cost-effective type of telephone intervention before widespread adoption of reminder and counseling systems can occur. We propose to compare a low intensity and a high intensity reminder/counseling protocol to a mailed reminder alone in a large closed panel HMO. The HMO is committed to incorporating the most study's successful interventions.,132935,CLHP,Community-Level Health Promotion Study Section,,2,671363,
7795923,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA133001-02,,NCI:362088;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073724262,US,PA,191112434,FOX CHASE CANCER CENTER,"KLEIN-SZANTO, ANDRES J;",1865039;,5R01CA133001,04/01/2009,02/28/2013,"Actinic Rays; Biological Function; Biological Process; Biomedical Engineering; Cancer Induction; Cancers; Carcinoma, Epidermoid; Carcinoma, Planocellular; Carcinoma, Squamous; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Proliferation; Complementary DNA; DNA, Complementary; Development; Early Diagnosis; Endopeptidase PC2; Enzymes; Epidermis; Esteroproteases; Experimental Animal Model; Exposure to ultraviolet radiation; Family; GFAC; Generalized Growth; Growth; Growth Agents; Growth Factor; Growth Factor Receptors; Growth Factors, Proteins; Growth Substances; Growth and Development; Growth and Development function; Human; Human, General; Impairment; Lead; MMP11; MMP11 gene; MMPs; Malignant Cell; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Melanoma and Non-Melanoma Skin Cancer; Mice; Mice, Transgenic; Modeling; Murine; Mus; Neuroendocrine Convertase PC2; PC2; PC2 Endoprotease; PC2 Protein; Pathogenesis; Pb element; Peptidases; Peptide Hydrolases; Peptides; Physiologic; Physiological; Play; Pre-Malignant; Predisposition; Premalignant; Process; Prohormone Convertase 2; Prohormone Convertase, PC2; Proinsulin Convertase 2; Proprotein Convertase 2; Proprotein Convertases; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Proto-Oncogene, Growth Factor Receptor; Protocol; Protocols documentation; Public Health Applications; Public Health Applications Research; Receptor Protein; Relative; Relative (related person); Role; SL-3; ST3; STMY3; Series; Skin; Skin Cancer; Skin Cancer, Including Melanoma; Skin Carcinogenesis; Skin Neoplasms; Squamous Cell Epithelioma; Squamous cell carcinoma; Substrate Specificity; Sun/Ultra-Violet Rays; Susceptibility; Testing; Tissue Growth; Transgenic Animals; Transgenic Mice; Transgenic Model; Transgenic Organisms; Tumor Cell; Tumor of the Skin; UV Radiation Exposure; UV carcinogenesis; UV exposure; UV induced; UV induced carcinogenesis; UV radiation; Ultraviolet Radiation Related Exposure; Ultraviolet Rays; base; bioengineering; bioengineering/biomedical engineering; cDNA; cancer cell; carcinogenesis; design; designing; early detection; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; keratinocyte; malignancy; mouse model; neoplasm/cancer; neoplastic; neoplastic cell; ontogeny; overexpression; precancerous; public health relevance; receptor; research study; social role; synergism; transgenic; tumor; tumor growth; ultraviolet light; ultraviolet radiation",Furin and the Etiopathogenesis of UV-Induced Skin Cancer," Relevance to Public Health This application will use modern experimental animal models to dissect the function of proprotein convertases, enzymes that activate relevant cancer-associated biomolecules, during the early formation and growth of squamous cell carcinomas, one of the most common cancers of the human skin. The proposed studies will lead to the identification of mechanisms involved in the origination of cancer that could be of great practical value in its early diagnosis and treatment.",133001,CE,Cancer Etiology Study Section,,2,362088,
7759227,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133021-03,,NCI:319457;,2010,NATIONAL CANCER INSTITUTE,,NEW BRUNSWICK,UNITED STATES,BIOLOGY,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"YANG, CHUNG S;",1862961;,5R01CA133021,04/01/2008,01/31/2013,"6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))-; A/J Mouse; ANOVA; Abbreviations; Acids; Active Oxygen; Adenocarcinoma; Adenoma, Malignant; Anabolism; Analysis of Variance; Animal Experiments; Apoptosis; Apoptosis Pathway; Arachidonic Acids; Biochemical; Blood (Leukemia); Blood Plasma; Butanones; CDK; COX-2; COX-2 protein; COX2; COX2 enzyme; Cancer cell line; Cancer of Lung; Carcinogenesis Inhibition; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell/Tissue, Immunohistochemistry; CellLine; Cellular Proliferation; Cholest-5-en-3-ol (3beta)-; Cholesterol; CoA; Coenzyme A; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclo-Oxygenase-2; Cyclooxygenase; D-Glucose; DNA Polymerase Delta Auxiliary Protein; Dehydrogenases; Dextrose; Diet; Dinoprostone; Dose; Drugs; EGCG; EGCG cpd; EGFR; ERBB Protein; ERBB1; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epigallocatechin Gallate; Epigallocatechingallate; Erythrocuprein; Experiments, Animal; GGDP; GGPP cpd; GRP78; Glucose; Green Tea Extract; Green Tea Polyphenols; H2A Histone Family, Member X; H2A histone family, member X protein, human; H2A.X protein, human; H2A/X; H2AFX; H2AFX protein, human; H2AX; H2AX protein, human; HER1; Hemocuprein; Histone H2A.X; Histone H2AX; Human; Human, General; IGF-1 Receptor; IGF1R; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Nick-End Labeling; In Vitro; Insulin-Like Growth Factor 1 Receptor; Insulin-Like-Growth Factor I Receptor; Intermediary Metabolism; Investigation; Iodide, Propidium; JNK; JNK1; JNK1A2; JNK21B1/2; LTB4; Label; Leukemias, General; Leukotriene B-4; Leukotriene B4; Lung; Lung Parenchyma; Lung Tissue; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; METBL; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Membrane; Metabolic Processes; Metabolism; Mice; Modeling; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Murine; Mus; Myeloid Cells; Names; Oxidative Stress; Oxidoreductase; Oxygen Radicals; PCNA-Cyclin; PGE2; PGE2 alpha; PGE2alpha; PGG/HS; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PHS-2; PRKM8; PTGS2; PTGS2 gene; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; Polyphenon E; Polyphenon E Topical Ointment; Prevention of Lung Cancer; Preventive; Pro-Oxidants; Proliferating Cell Nuclear Antigen; Propidium Diiodide; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Proteins; Public Health; Pulmonary Cancer; Pulmonary malignant Neoplasm; Reactive Oxygen Species; Receptor, EGF; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Reductases; Respiratory System, Lung; Reticuloendothelial System, Serum, Plasma; SAPK1; SOD; Sampling; Serum, Plasma; Signal Transduction Pathway; Small G-Proteins; Small GTPases; Staging; Structure of parenchyma of lung; Superoxide Dismutase; Superoxide[{..}]superoxide oxidoreductase; TUNEL; Tea; Tea catechin; Testing; Transforming Growth Factor alpha Receptor; VEGFs; Variance Analyses; Vascular Endothelial Growth Factors; Vegf; abstracting; adenoma; angiogenesis; atorvastatin; base; biosynthesis; c-erbB-1; c-erbB-1 Protein; cdk Proteins; cultured cell line; cyclo-oxygenase II; cyclooxygenase 2; cytocuprein; diphosphoric acid, mono(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl) ester, (E,E,E)-; drug/agent; epigallo-catechin gallate; epigallocatechin; epigallocatechol; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; farnesyl diphosphate; farnesyl pyrophosphate; farnesylpyrophosphate; gallocatechin; gallocatechol; gene product; geranylgeraniol diphosphate; geranylgeranyl pyrophosphate; hCOX-2; human H2AX protein; in vivo; isoprenoid; leukemia; lipitor; lung cancer; lung cancer prevention; lung carcinogenesis; lung tumorigenesis; membrane structure; polyphenol; prostaglandin H synthase-2; proto-oncogene protein c-erbB-1; public health medicine (field); public health relevance; pulmonary; response; terminal nick end labeling; tumor",Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin,,133021,CDP,Chemo/Dietary Prevention Study Section,,3,319457,
7755375,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133027-03,,NCI:300378;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"SUGDEN, WILLIAM M.;",1888497;,5R01CA133027,04/23/2008,01/31/2013,"21+ years old; AIDS; AIDS Lymphoma; AIDS-Associated Lymphoma; AIDS-Related Lymphoma; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adult; Africa; Apoptosis; Apoptosis Pathway; B blood cells; B cell tumor; B-Cell Lymphocytic Neoplasm; B-Cell Neoplasm; B-Cells; B-Lymphocytes; B-lineage tumor; Burkitt Herpesvirus; Burkitt Lymphoma; Burkitt Lymphoma Virus; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Carcinoma; Carcinoma of Nasopharynx; Cell Death, Programmed; Cells; Childhood Burkitt's Lymphoma; Childhood Small Non-Cleaved Cell Lymphoma; China; Couples; Coupling; DLBCL; Dependence; Diffuse Large B-Cell Lymphoma; Diffuse non-Hodgkin's lymphoma, large cell; E-B Virus; EB virus; EBV; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epstein Barr Virus; Epstein-Barr Virus; Event; Generalized Growth; Genes; Genes, Regulator; Genes, Viral; Genome; Genomics; Germinoblastoma; Goals; Growth; HHV-4; HIV Associated Lymphoma; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Human; Human Herpesvirus 4; Human, Adult; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Infection; Infectious Mononucleosis Virus; Life; Lymphogranuloma, Malignant; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, AIDS-Related; Lymphoma, HIV-Related; Lymphoma, Malignant; Lymphoproliferative Disorders; Mainland China; Maintenance; Maintenances; Malignant; Malignant - descriptor; Man (Taxonomy); Man, Modern; Maps; Measures; Methods; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; Oncogenesis; Oncogenic Viruses; Patients; Pediatric Burkitt's Lymphoma; Pediatric Small Non-Cleaved Cell Lymphoma; Phase; Phenotype; Plasmids; Proliferating; Property; Property, LOINC Axis 2; Proteins; Regulator Genes; Replication Unit; Replicon; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Site; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Time; Tissue Growth; Transcriptional Regulatory Elements; Transplantation; Tumor Cell; Tumor Viruses; Viral; Viral Gene Products; Viral Gene Proteins; Viral Genes; Viral Genome; Viral Proteins; Work; adult human (21+); antitumor drug; cis acting element; epithelial carcinoma; fascinate; gene product; human DNA; human herpesvirus 4 group; immunosuppressed patient; infected B cell; infected B lymphocyte; inhibitor; inhibitor/antagonist; large cell Diffuse non-Hodgkin's lymphoma; lymphogranulomatosis; lymphogranulomatosis (malignant); lymphoproliferative disease; neoplastic cell; ontogeny; prevent; preventing; public health relevance; regulatory gene; replicator; social role; trans acting element; transplant; tumor; tumorigenesis; virus protein","EBV's Plasmid Replicon: Its Synthesis, Partitioning, and Maintenance of Tumors",,133027,ZRG1,Special Emphasis Panel,,3,300378,
7759548,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133046-03,,NCI:283860;,2010,NATIONAL CANCER INSTITUTE,,ANN ARBOR,UNITED STATES,PHARMACOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"CANMAN, CHRISTINE ELIZABETH;",8688633;,5R01CA133046,04/10/2008,01/31/2013,"(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4'[{..}]6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione; (SP-4-2)-Diamminedichloroplatinum; 1H-Pyrano(3',4'[{..}]6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI); 20-(S)-camptothecine; 21, 22-secocamptothecin-21-oic acid lactone; A-T protein; AT Mutated; AT mutated protein; ATM Protein; ATM Serine/Threonine Protein Kinase; ATR; ATR protein kinase; Abbreviations; Aberrant Chromosome; Abnormalities, Chromosomal; Address; Affect; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Ataxia Telangiectasia Mutated; Ataxia Telangiectasia Protein; Ataxia Telangiectasia and Rad3 Related Protein; Bioassay; Biologic Assays; Biological Assay; Bypass; CDDP; Camptothecin; Cancer Drug; Cancers; Carcinoma Cell; Carcinoma of the Uterine Cervix; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Cycle Checkpoint; Cell Survival; Cell Viability; Cells; Cervical Carcinoma; Cervix Uteri Carcinoma; Cervix carcinoma; Chemotherapeutic Agents, Neoplastic Disease; Chickens; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Combination Drug Therapy; Complex; Cysplatyna; Cytogenetic Aberrations; Cytogenetic Abnormalities; DDP; DNA; DNA Damage Repair; DNA Double Strand Break; DNA Interstrand Crosslinking; DNA Intrastrand Crosslinking; DNA Nicking-Closing Protein; DNA Polymerase Delta Auxiliary Protein; DNA Polymerases; DNA Recombination; DNA Relaxing Enzyme; DNA Relaxing Protein; DNA Repair; DNA Replication; DNA Synthesis; DNA Topoisomerase I; DNA Topoisomerases, Type I; DNA Type 1 Topoisomerase; DNA Untwisting Enzyme; DNA Untwisting Protein; DNA biosynthesis; DNA lesion; DNA polymerase eta; DNA polymerase zeta; DNA recombination (naturally occurring); DNA, Single-Stranded; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Data; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Dichlorodiammineplatinum; Double Strand Break Repair; Drug usage; Drugs; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7.7.7; Electromagnetic Radiation, Ionizing; Enzymes; Event; Exhibits; Exposure to; FRAP-Related Protein-1; FRP1; Frequencies (time pattern); Frequency; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Conversion; Genetic Recombination; Genome Instability; Genomic Instability; Germinoblastoma; Goals; HeLa; Hela Cells; Homologous Recombinational Repair; Human; Human, General; Ionizing radiation; Kinetic; Kinetics; Lead; Lesion; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Markers, Surrogate; Measures; Mediating; Medication; Mitomycin Antibiotic; Mitomycins; Modeling; Molecular; Monoubiquitination; Nuclear; PCNA-Cyclin; POLH gene product; Pathway interactions; Pb element; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Play; Polychemotherapy; Polymerase; Process; Proliferating Cell Nuclear Antigen; Proteins; RAD30 gene product; RAD30A; RNA, Small Interfering; Rad3 Related Protein; Rad30 protein; Radiation Sensitivity; Radiation Tolerance; Radiation-Ionizing Total; Radiosensitivity; Reagent; Recombination; Recombination Repair; Recombination, Genetic; Recruitment Activity; Reporter; Resistance; Resolution; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Single-Stranded DNA; Sister Chromatid Exchange; Site; Small Interfering RNA; Surrogate Markers; TOP1; TOP1 gene; Testing; Topoisomerase I; Tumor Cell; Tumor-Specific Treatment Agents; Type I DNA Topoisomerases; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Unscheduled DNA Synthesis; XP-V gene product; XPV gene product; adduct; anticancer agent; anticancer drug; ataxia telangiectasia mutated protein; base; cancer cell; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; combination pharmacotherapy; coping; cross-link; crosslink; design; designing; drug development; drug use; drug/agent; effective therapy; gene product; heavy metal Pb; heavy metal lead; homologous recombination; inhibitor; inhibitor/antagonist; insight; malignancy; neoplasm/cancer; neoplastic cell; nicking closing enzyme; novel; pathway; poleta; prevent; preventing; recombinational repair; recruit; relaxing enzyme; repair; repaired; resistant; response; siRNA; social role; swivelase; therapeutic effectiveness; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase; untwisting enzyme",Novel Mechanisms by which RAD18 and POLZ affect Response to Anticancer Agents,,133046,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,3,283860,
7772319,R01,CA,5,,01/27/2010,12/31/2010,PA-07-070,5R01CA133057-02,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,OTHER HEALTH PROFESSIONS,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"MOK, SAMUEL C;",1903845;,5R01CA133057,03/01/2009,12/31/2013,"5q31; AFGF; Accounting; Alpha Fibroblast Growth Factor; Animal Model; Animal Models and Related Studies; Beta-Endothelial Cell Growth Factor; Cancer Cause; Cancer Etiology; Cancer cell line; Cancer of the Ovary; Cancers; Candidate Disease Gene; Candidate Gene; Carcinoma; Cessation of life; Chromosome 5q31; Chronic; Clinical Course of Disease; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Collection; Comparative Genome Hybridization; Cystadenocarcinoma, Serous; DNA; DNA copy number; Data; Death; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disease model; Disorder; Drug resistance; ECGF; ECGF-alpha; ECGF-beta; ECGFA; ECGFB; Early Diagnosis; Endothelial Cell Growth Factor, Alpha; Epithelial; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epithelial ovarian cancer; Expression Profiling; Expression Signature; FGF-1; FGF1; FGF1 gene; FGFA; Female; Fibroblast Growth Factor 1; Fibroblast Growth Factor, Acidic; Fibroblast growth factor (human brain acidic protein moiety reduced); Forecast of outcome; GOG; Gene Expression; Gene Products, RNA; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genital; Genital System, Female, Ovary; Genital system; Genomics; Goals; Gynecologic Oncology Group; HBGF-1; HBGF1; Heparin Binding Growth Factor-1; Heparin-Binding Fibroblast Growth Factor Class I; Heparin-Binding Growth Factor, Class I; Indolent; Malignant Neoplasms; Malignant Ovarian Neoplasm; Malignant Ovarian Tumor; Malignant Tumor; Malignant Tumor of the Ovary; Malignant neoplasm of ovary; Messenger RNA; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Modeling; Molecular Fingerprinting; Molecular Marker of Prognosis; Molecular Profiling; Monitor; Mutation; Neoplasm Metastasis; Oligonucleotide Array; Oligonucleotide Microarrays; Operation; Operative Procedures; Operative Surgical Procedures; Ovarian Serous Adenocarcinoma; Ovarian Serous Carcinoma; Ovarian Tumor; Ovary; Ovary Neoplasms; Patients; Phase 3 Clinical Trials; Phase III Clinical Trials; Prognosis; Prognosis Marker; Prognostic Marker; Progression-Free Survivals; Prostatropin; Proteins; Protocol; Protocols documentation; RNA; RNA Expression; RNA, Messenger; RNA, Non-Polyadenylated; Research; Research Specimen; Ribonucleic Acid; Sampling; Screening procedure; Secondary Neoplasm; Secondary Tumor; Serous; Serous Adenocarcinoma; Serous Adenocarcinoma of the Ovary; Serous Carcinoma of the Ovary; Serous Cystadenocarcinoma; Specimen; Staging; Stratification; Surface; Surgical; Surgical Interventions; Surgical Procedure; Survivals, Progression-Free; Tissue Sample; Transcription; Transcription, Genetic; Tumor Cell; Tumor Cell Migration; Tumor Tissue; Tumor of the Ovary; United States; Woman; Work; advanced disease; base; biomarker; cancer metastasis; candidate marker; chemotherapy; clinical investigation; comparative genomic hybridization; d-Numb; disease/disorder; disorder model; drug resistant; early detection; epithelial carcinoma; gene product; genome mutation; improved; mRNA; malignancy; model organism; molecuar profile; molecular signature; mouse model; neoplasm/cancer; neoplastic cell; numb protein; outcome forecast; ovarian cancer; ovarian neoplasm; phase 3 study; phase 3 trial; phase III trial; prognostic; protein expression; protocol, phase III; public health relevance; resistance to Drug; resistant to Drug; screening; screenings; study, phase III; surgery; therapeutic target; tool; urogenital system (genital part); validation studies",Prognostic markers for ovarian cancer," Project Narrative  The proposed studies seek to perform further validation studies on genes located in the 12 comparative genomic hybridization (CGH) segments that are significantly associated with progression free and overall survival in patients with high-grade advanced stage serous ovarian cancer using a large collection of clinical trial specimens. Validated genetic changes will be used to compare with those identified in other histological types of ovarian cancers. By combining with transcriptional profiling data, validated candidate genes will be used to develop a genetic prognostic model for the disease. We will focus on genes that are associated with worse overall and progression free survival and with chemoresistance for further functional studies. A panel of genetically characterized ovarian cancer cell lines and an orthotopic ovarian cancer mouse model will be used to further validate the prognostic value of each selected candidate marker.",133057,CG,Cancer Genetics Study Section,,2,319550,
7786255,R01,CA,5,,01/14/2010,12/31/2010,PA-07-070,5R01CA133209-02,,NCI:235305;,2010,NATIONAL CANCER INSTITUTE,,DAVIS,UNITED STATES,UROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"GHOSH, PARAMITA M;",1894674;,5R01CA133209,03/13/2009,12/31/2013,"4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide; 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide; 4-Cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline; 70-kDa Ribosomal Protein S6 Kinases; Affect; Androgen Antagonists; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Anti-Androgen; Anti-Androgen Agents; Antiandrogen Agents; Antiandrogens; Apoptosis; Apoptosis Pathway; Apoptotic; Astra brand of bicalutamide; AstraZeneca brand of bicalutamide; Autophagocytosis; Bicalutamide; Binding Proteins; Birds of Prey; Body Tissues; Cancer of Prostate; Casodex; Cell Cycle Arrest; Cell Death Induction; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Chemotherapy-Hormones/Steroids; Clinical Trials, Phase III; Complex; Cosudex; Development; Drug Combinations; Drugs; EC 2.7; Endocrine Gland Secretion; Endocrine Therapy; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FLR; FRAP1 protein, human; Failure (biologic function); Generalized Growth; Growth; Hand; Hormonal Therapy; Hormones; Human; Human, General; Inhibition of Apoptosis; Kinases; Lead; Ligand Binding Protein; Ligands; Malignant Cell; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Mediating; Medication; Modeling; N-[4-Cyano-3-(trifluoromethyl)phenyl]3-3[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Phosphorylation; Phosphotransferases; Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-; Prostate CA; Prostate Cancer; Prostate Neoplasms; Prostatic Cancer; Prostatic Neoplasia; Prostatic Neoplasms; Protein Phosphorylation; RAFT1 protein, human; RAPT1 protein, human; Rapamune; Rapamycin; Rapamycin Target Protein; Raptors; Recurrence; Recurrent; Refractory; Regulation; Resistance; Ribosomal Protein S6 Kinases, 70-kDa; Role; Signal Transduction Pathway; Sirolimus; Testing; Therapeutic; Therapeutic Androgen; Therapeutic Hormone; Time; Tissue Growth; Tissues; Translation Initiation; Transphosphorylases; Tumor of the Prostate; Withdrawal; Zeneca brand of bicalutamide; androgen independent prostate cancer; androgen inhibitor; autophagy; cancer cell; cancer progression; cell growth; deprivation; design; designing; drug/agent; experience; failure; heavy metal Pb; heavy metal lead; hormone therapy; human FRAP1 protein; in vivo; mTOR; mTOR Inhibitor; neoplasm progression; neoplastic progression; novel; ontogeny; p70 S6 Kinase; p70s6k; pathway; phase 3 study; phase 3 trial; phase III trial; preclinical study; prevent; preventing; protocol, phase III; public health relevance; rapamycin and FKBP12 target 1 protein, human; resistant; social role; study, phase III; tumor; tumor progression",Rapamycin Regulation of the Androgen Receptor: Implications in Prostate Cancer," PROJECT NARRATIVE: This is the first time that the combination of rapamycin and bicalutamide will be used in preclinical studies for the treatment of androgen-independent prostate cancer. The combination of these drugs has not been shown before to sensitize hormone-refractory cells to hormone therapy (androgen deprivation or anti-androgens). The studies proposed here would justify a Phase II/Phase III clinical trial utilizing the combination of bicalutamide and rapamycin for the treatment of patients who experience recurrent prostate cancer. Currently, the options for patients with androgen-independent prostate cancer are limited; hence such a study would open the doors for a new treatment option.",133209,DT,Developmental Therapeutics Study Section,,2,235305,
7758341,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133229-03,,NCI:308138;,2010,NATIONAL CANCER INSTITUTE,,SAN ANTONIO,UNITED STATES,ANATOMY/CELL BIOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"KELLER, CHARLES ;",6360646;,5R01CA133229,04/22/2008,01/31/2013,"0-11 years old; 1-Phosphatidylinositol 3-Kinase; 21+ years old; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Ablation; Activities of Daily Living; Activities of everyday life; Address; Adult; Alleles; Allelomorphs; Alveolar Rhabdomyosarcoma; Anchorage-Independent Growth; Antioncogene Protein p53; Assay; Autocrine Systems; Bioassay; Biologic Assays; Biological; Biological Assay; Breeding; CD140B; Cancer Genes; Cancer Patient; Cancer-Promoting Gene; Cancers; Cause of Death; Cell Communication and Signaling; Cell Culture Techniques; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cellular Tumor Antigen P53; Child; Child Youth; Childhood; Childhood Alveolar Rhabdomyosarcoma; Children (0-21); Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Complex; Data; Diagnosis; Disease; Disease Progression; Disorder; Distant; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug resistance; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Enrollment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Extracellular Signal-Regulated Kinase Gene; Foundations; Frequencies (time pattern); Frequency; Future; Gene Expression; Generations; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; HEK3; Human; Human, Adult; Human, Child; Human, General; Imatinib; In Vitro; Intracellular Communication and Signaling; Isoforms; JTK12; Knock-out; Knockout; Ligands; Lymph node proper; Lymphatic; MAP Kinase Gene; MAPK; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Muscle; Malignant neoplasm of muscle; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Messenger RNA; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Murine; Mus; Muscle Cancer; Muscle, Skeletal; Muscle, Voluntary; Mutation; Neoplasm Metastasis; Oncogenes; Oncoprotein p53; Outcome; P53; PDGF; PDGF-A; PDGF-A protein; PDGF-C; PDGF-CC; PDGF-R-Beta; PDGFA protein; PDGFR; PDGFR1; PDGFRB; PDGFRB gene; PI-3 Kinase; PI-3K; PI3-Kinase; PTK; PTK Inhibitors; Pathogenesis; Pathway interactions; Patients; Pediatric Alveolar Rhabdomyosarcoma; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Pilot Projects; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor Receptor; Play; Primary Neoplasm; Primary Tumor; Protein Isoforms; Protein Phosphorylation; Protein TP53; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase Inhibitors; Protein p53; Proteins; PtdIns 3-Kinase; RNA, Messenger; RNA, Small Interfering; Receptor Protein; Receptors, PDGF; Refractory; Research; Reticuloendothelial System, Lymph Node; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Role; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Small Interfering RNA; Solid Neoplasm; Solid Tumor; Specificity; Staging; System; System, LOINC Axis 4; TK Inhibitors; TP53; TP53 gene; TRP53; Testing; Therapeutic; Therapeutic Effect; Transcription Activation; Transcriptional Activation; Transforming Genes; Translating; Translatings; Treatment Failure; Tumor Cell Migration; Tumor Protein p53; Tumor Protein p53 Gene; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine Kinase; Tyrosine Kinase Inhibitor; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Up-Regulation; adult human (21+); autocrine; base; biological signal transduction; cancer metastasis; cancer progression; children; clinical investigation; daily living functionality; disease/disorder; drug resistant; enroll; experiment; experimental research; experimental study; functional ability; functional capacity; fusion gene; gene product; genome mutation; human disease; hydroxyaryl protein kinase; improved; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; insight; language translation; lymph gland; lymph nodes; mRNA; malignancy; malignant muscle neoplasm; membrane structure; migration; mouse model; neoplasm progression; neoplasm/cancer; neoplastic progression; p53 Antigen; p53 Tumor Suppressor; paracrine; pathway; pediatric; pilot study; platelet-derived growth factor A; platelet-derived growth factor C; public health relevance; receptor; research study; resistance to Drug; resistant to Drug; response; siRNA; social role; therapeutic target; tumor; tumor growth; tumor progression; tyrosyl protein kinase; youngster",Therapeutic Targets in Alveolar Rhabdomyosarcoma,,133229,TCB,Tumor Cell Biology Study Section,,3,308138,
7758312,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133249-03,,NCI:318513;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"SONGYANG, ZHOU ;",7357783;,5R01CA133249,04/01/2008,01/31/2013,"Affect; Aging, Premature; Animal Welfare; Antimorphic mutation; Bibliography; Binding Proteins; Cancers; Cell Cycle; Cell Cycle Checkpoint; Cell Division Cycle; Cell Survival; Cell Viability; Cells; Complex; Country; DNA Damage; DNA Injury; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genomic Instability; Goals; Hematologic Body System; Hematologic Cancer; Hematologic Malignancies; Hematologic Neoplasms; Hematological Malignancies; Hematological Neoplasms; Hematological Tumor; Hematopoietic; Hematopoietic Body System; Hematopoietic Cancer; Hematopoietic System; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knock-out; Knockout; Lead; Length; Ligand Binding Protein; Link; Malignant Hematologic Neoplasm; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Molecular; Murine; Mus; Mutation; Names; Organ System, Hematologic; PIN2; Pb element; Physiopathology; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-Translational Modifications; Post-Translational Protein Processing; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Posttranslational Modifications; Premature aging syndrome; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Research; Research Ethics Committees; Research Resources; Resources; Role; Sequence-Specific Posttranscriptional Gene Silencing; TERF1; TERF1 (TRF1)-Interacting Nuclear Factor 2 Gene; TERF1 gene; TIN2; TIN2 Gene; TINF2; TINF2 gene; TRBF1; TRF1; TRF1-Interacting Nuclear Protein 2 Gene; Telomerase; Telomere Maintenance; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Vertebrate Animals; Vertebrates; abstracting; disease/disorder; expiration; gene product; genome mutation; hTRF1-AS; heavy metal Pb; heavy metal lead; human subject; intervention development; malignancy; neoplasm/cancer; pathophysiology; programs; reconstitute; reconstitution; response; shRNA; short hairpin RNA; small hairpin RNA; social role; telomere; therapy development; treatment development; ubiquination; ubiquitin conjugation; vertebrata",Mechanism and Consequences of Telomere Dysfunction,,133249,CAMP,Cancer Molecular Pathobiology Study Section,,3,318513,
7778817,R01,CA,5,,02/01/2010,01/31/2011,PA-07-301,5R01CA133458-03,,NCI:308775;,2010,NATIONAL CANCER INSTITUTE,,AUGUSTA,UNITED STATES,BIOCHEMISTRY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"SREEKUMAR, ARUN ;",8615037;,5R01CA133458,04/04/2008,01/31/2013,"Aminoacetic Acid; Analysis, Data; Animal Model; Animal Models and Related Studies; Area; Benign; Biochemical Pathway; Biological; Biology; Blood Plasma; Body Tissues; Cancer Cause; Cancer Detection; Cancer Etiology; Cancer Model; Cancer of Prostate; CancerModel; Cancers; Cessation of life; Clinical; Clinical Pathology; Complex; Data; Data Analyses; Death; Detection; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Disorder; EC 3.4.21.34; Early Diagnosis; Event; Extraprostatic; Family; Fletcher Factor; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Fusion; Generalized Growth; Genital System, Male, Prostate; Glycine; Glycine, N-methyl-; Goals; Growth; Human Prostate; Human Prostate Gland; In Vitro; Investigation; KLK3; Kallikrein 3; Knowledge; Laboratories; Lead; Light; Link; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mass Spectrum; Mass Spectrum Analysis; Measures; Metabolic Networks; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Prostate Cancer; Metastatic Tumor; Methylglycine; Mining; Minings; Modeling; Molecular; Molecular Analysis; Molecular Marker of Prognosis; Motivation; N-Methylglycine; Neoplasm Metastasis; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Outcome; P-30 Antigen; Pathology, Clinical; Pathway interactions; Patient Selection; Patients; Pb element; Phase; Photometry/Spectrum Analysis, Mass; Photoradiation; Plasma; Plasma Kallikrein Precursor; Plasma Prekallikrein; Pre-Clinical Model; Preclinical Models; Process; Profilings, Gene Expression; Prognosis Marker; Prognostic Marker; Progressive Disease; Prostate; Prostate CA; Prostate Cancer; Prostate Carcinoma Metastatic; Prostate Gland; Prostate Neoplasms; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Proteomics; Radiation; Research Specimen; Reticuloendothelial System, Serum, Plasma; Role; Sarcosine; Secondary Neoplasm; Secondary Tumor; Semenogelase; Seminin; Serum, Plasma; Specificity; Specimen; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Tissue Growth; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; Tumor Cell Migration; Tumor of the Prostate; Urinary System, Urine; Urine; Validation; Western World; base; biomarker; cancer initiation; cancer metastasis; cancer microarray; cancer progression; clinical relevance; clinically relevant; data mining; datamining; disease/disorder; early detection; falls; gamma-Seminoprotein; hK3 Kallikrein; heavy metal Pb; heavy metal lead; in vivo Model; insight; kininogenin; mRNA Expression; malignancy; measurement of metabolism; men; men's; metabolomics; model organism; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; older men; ontogeny; pathway; pre-clinical; preclinical; protein function; ray (radiation); social role; success; surgery; tool; transcription factor; transcriptomics; tumor; tumor progression",Integrative Metabolomics of Prostate Cancer Progression,,133458,CBSS,Cancer Biomarkers Study Section,,3,308775,
7775033,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA133522-02,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"SARBASSOV, DOS DJURMAKHANBET;",9094341;,5R01CA133522,03/01/2009,01/31/2014,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Applications Grants; Breast Cancer Cell; Breast Cancer Model; Breast Neoplasms; Breast Tumors; Cancer Drug; Cancer Treatment; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Cycle Progression; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cellular Transformation; Chemotherapeutic Agents, Neoplastic Disease; Complex; Data; Development; Disease Progression; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7; Epithelial Cells; GFAC; Goals; Grant Proposals; Grants, Applications; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human Breast Cancer Cell; Human, General; Hyperplasia; Hyperplastic; Intermediary Metabolism; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinases; Knowledge; Laboratories; Link; METBL; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Processes; Metabolic syndrome; Metabolism; Metastatic to; Oncogenesis; Outcome; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphotransferases; Preventive; Protein Phosphorylation; PtdIns 3-Kinase; RAFT-1 gene product; Regulation; Research; Role; Sampling; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stream; Testing; Therapeutic; Transphosphorylases; Tumor Cell Invasion; Tumor Invasion; Tumor-Specific Treatment Agents; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; anticancer agent; anticancer drug; anticancer therapy; base; biological signal transduction; breast tumorigenesis; cancer progression; cancer therapy; cell growth; in vivo; innovate; innovation; innovative; interest; interventional strategy; mTOR gene product; mTOR protein; malignancy; malignant breast neoplasm; mammalian target of rapamycin (mTOR); mammary; mammary cancer model; mammary tumor; mammary tumor model; metaplastic cell transformation; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; pathway; public health relevance; social role; tumor; tumor progression; tumorigenesis",The mTORC2 signaling in breast cancer," PROJECT NARRATIVE The central hypothesis of this application is that during cellular transformation the mTORC2 signaling is up-regulated to activate the Akt pathway as an important step in development of primary breast cancer tumors. In this grant application we propose to study induction of mTORC2 in breast cancer, its regulation, and its role in breast tumorigenesis. The rationale for proposed research is that, once we know the regulatory mechanism of the mTORC2 complex by dissecting its up-stream and downstream regulators, this complex will become accessible target to pharmacological intervention with potential application to treat cancer.  ",133522,TCB,Tumor Cell Biology Study Section,,2,319550,
7768458,R01,CA,5,,02/01/2010,01/31/2011,PAR-07-270,5R01CA133525-03,,NCI:313325;,2010,NATIONAL CANCER INSTITUTE,,HERSHEY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"LOUGHRAN, THOMAS PATRICK;",1943873;,5R01CA133525,03/01/2008,01/31/2013,"4-Amino-10-methylfolic Acid; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; Adopted; Animal Model; Animal Models and Related Studies; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Apoptosis; Apoptosis Pathway; Apoptotic; C(6)-ceramide; C6-ceramide; CD8; CD8B; CD8B1; CD8B1 gene; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell Surface Antigens; Cells; Ceramide (lipids); Ceramides; Clinical; Cytotoxic cell; Data; Development; Disease; Disorder; Dose; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; Encapsulated; Fischer Rats; Formulation; Formulations, Drug; Foundations; Gene Expression Inhibitor; Generations; Goals; Immunoliposome; In Vitro; Inbred F344 Rats; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; K lymphocyte; Killings; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-; LEUKCL; LGL; LGLL; LYT3; Laboratories; Large Cell Granular Lymphogenous Leukemia; Large Cell Granular Lymphoid Leukemia; Large Granular Lymphocytic Leukemia; Large Granular Lymphocytosis; Large granular lymphocyte; Leukemia, T-Cell, Chronic; Leukemic Cell; Licensing; Lipids; Liposomal; Liposomes; Lymphocytic Leukemia, T-Cell, Chronic; MCL1 protein; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mcl-1 protein; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Medicine; Methods; Methotrexate; Methotrexate Methylaminopterin; Methotrexatum; Metotrexato; Moab, Clinical Treatment; Modeling; Molecular; Monoclonal Antibodies; N-caproylsphingosine; N-hexanoylsphingosine; NCI; NCI Organization; NK Cells; Nanoscale Science; Nanotechnology; National Cancer Institute; Natural Killer Cells; Oligonucleotides, Antisense; Oncogenic; PBMC; Pathogenesis; Pathway interactions; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacology; Play; RNA, Small Interfering; Rats, F344; Rats, Inbred CDF; Rats, Inbred F344; Rats, Inbred Fischer 344; Rats, Inbred Fisher 344; Research; Research Personnel; Researchers; Resistance; Role; STAT3; STAT3 gene; Science of Medicine; Second Messenger Systems; Second Messengers; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; T-Cell CLL; T-Cell Chronic Lymphogenous Leukemia; T-Cell Chronic Lymphoid Leukemia; T-Cell Large Granular Lymphocyte Leukemia; T-Cell Large Granular Lymphocytic Leukemia; T-Cells; T-Gamma Lymphoproliferative Disorder; T-Lymphocyte; T-Lymphocytic Leukemia, Chronic; Technology; Testing; Tgamma Large Granular Lymphocyte Leukemia; Therapeutic; Thymus-Dependent Lymphocytes; Toxicology; analog; base; biological signal transduction; cancer cell; college; combinatorial; design; designing; disease/disorder; drug/agent; experiment; experimental research; experimental study; human subject; improved; in vivo; induced myeloid leukemia cell differentiation protein Mcl-1; innovate; innovation; innovative; intervention development; large granular lymphocyte leukemia; malignancy; model organism; myeloid cell factor-1; myeloid cell leukemia sequence 1; nano meter scale; nano meter sized; nano scale; nano scale Science; nano tech; nano technology; nanometer scale; nanometer sized; nanoscale; nanotech; neoplasm/cancer; new approaches; next generation; novel; novel approaches; novel strategies; novel strategy; pathway; research study; resistant; second messenger; siRNA; social role; stability testing; therapeutic target; therapy development; thymus derived lymphocyte; treatment development; tumor",Targeted Therapeutics of LGL Leukemia utilizing Ceramide Nanoliposomes,,133525,ZRG1,Special Emphasis Panel,,3,313325,
7751816,R01,CA,5,,01/15/2010,12/31/2010,PA-07-070,5R01CA133662-02,,NCI:318513;,2010,NATIONAL CANCER INSTITUTE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"TORETSKY, JEFFREY A;",6186864;,5R01CA133662,01/01/2009,11/30/2013,"0-11 years old; 3-D; 3-Dimensional; ABL Tyrosine Kinase; ABL1; Address; Adolescent; Adolescent Youth; Adverse effects; Amino Acids; Apoptosis; Apoptosis Pathway; Assay; Au element; Beta Sheet; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Blood (Leukemia); Bone; Bone Marrow Transplant; Bone Marrow Transplantation; Bone and Bones; Bones and Bone Tissue; CHIP assay; Cancer Genes; Cancer Patient; Cancer of Bone; Cancer of Prostate; Cancer-Promoting Gene; Cancers; Carcinoma; Cell Death; Cell Death, Programmed; Cell Line, Transformed; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Expansion; Cellular Growth; Cellular Migration; Cellular biology; ChIP (chromatin immunoprecipitation); Characteristics; Chemistry, Biological; Chemistry, Pharmaceutical; Child; Child Youth; Children (0-21); Chimera Protein; Chimeric Proteins; Chromosomal dislocation; Chromosomal translocation; Clinic; Clinical; Complex; Connective Tissue Sarcoma; DNA Molecular Biology; DTP; Developmental Therapeutics; Developmental Therapeutics Program; Developmental Therapy; Disease; Disease-Free Survival; Disorder; Dose; Drug Design; Drugs; EWS-FLI-1; EWS-FLI1; EWS-FLI1 fusion protein; EWSR2; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Event-Free Survival; Ewing Sarcoma Breakpoint Region 2; Ewing's Family of Tumours; Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Ewing's Tumor; Ewings sarcoma; Expression Profiling; Expression Signature; FLI1; FLI1 gene; Family; Family member; Forecast of outcome; Fusion Protein; Future; Gene Expression; Gene Transcription; Generalized Growth; Genetic Transcription; Gold; Grafting, Bone Marrow; Growth; Heterograft; Human, Child; Investigation; Killings; Knowledge; Lead; Leukemias, General; Libraries; Malignant Bone Neoplasm; Malignant Neoplasms; Malignant Osseous Neoplasm; Malignant Osseous Tumor; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Bone; Malignant Tumor of the Prostate; Malignant Tumor of the Soft Tissue; Malignant neoplasm of prostate; Malignant prostatic tumor; Marrow Transplantation; Math Models; Medication; Medicinal Chemistry; Metastatic Ewing's Sarcoma; Molecular Biology; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Molecular Target; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Non-Malignant; Oncogenes; Oncogenic; Osseous Cancer; P150; Patients; Pb element; Peptides; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Preparations; Prognosis; Property; Property, LOINC Axis 2; Prostate CA; Prostate Cancer; Prostatic Cancer; Proteins; Proto-Oncogene Tyrosine -Protein Kinase ABL; RHA enzyme; RNA Expression; RNA helicase A; Reagent; Recurrent disease; Regimen; Relapsed Disease; Reporter; Research; Resistance; SIC-1; Sarcoma of the Soft Tissue and Bone; Sarcoma, Soft Tissue; Screening procedure; Series; Specificity; Structure; Targeted Fusion Protein Therapy; Testing; Therapeutic Agents; Tissue Growth; Toxic effect; Toxicities; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transformed Cell Line; Transforming Genes; Translocation, Genetic; Transplantation, Heterologous; Treatment Side Effects; Tumor Cell; Work; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; adult youth; aminoacid; base; beta pleated sheet; bone; c-ABL Protein; cDNA Arrays; cDNA Microarray; cell biology; cell growth; cell motility; chemotherapy; children; chromatin immunoprecipitation; chromosome dislocation; chromosome translocation; design; designing; disease/disorder; drug discovery; drug/agent; epithelial carcinoma; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; juvenile; juvenile human; leukemia; malignancy; malignant phenotype; mathematical model; mathematical modeling; molecuar profile; molecular signature; necrocytosis; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; nonmalignant; novel; novel therapeutic intervention; novel therapeutics; oncogene protein pp60(v-src) (137-157); ontogeny; outcome forecast; peptide A; prevent; preventing; protein function; protein protein interaction; public health relevance; research study; resistant; response; sarcoma; screening; screenings; side effect; small molecule; soft tissue; success; therapy adverse effect; transcription factor; treatment adverse effect; tumor; tumor growth; tyrosine kinase ABL1; young adult; youngster",Novel Compounds to Inactivate Oncogenic Fusion Proteins," New targeted therapies are needed for cancer patients that improve survival and decrease side-effects of therapy. Ewing's Sarcoma Family of Tumors (ESFT) are highly malignant tumors of bone and soft tissue that occur in children, adolescents, and young adults. The tumors often grow in close proximity to bone, but can occur as a soft-tissue mass. Current standard therapy for ESFT patients is a five-drug regimen that lasts for approximately 9 months. Patients who present with localized ESFT have approximately 70% disease-free survival. Patients who present with metastatic ESFT have a poor prognosis (20% disease- free survival) despite intensive therapy. These clinical response rates have persisted for the past decade, even after dose-intensifying chemotherapy and bone marrow transplantation. Therefore, we need to discover novel therapeutic approaches to both reduce treatment related morbidity and improve overall survival. Fortunately, ESFT contain an ideal molecular target. Unfortunately, despite knowledge that inactivation of this ideal target causes ESFT cell death, strategies to inactivate the molecular target have not been brought to the clinic. This project will specifically address the need for new targeted therapies for ESFT and a large number of related malignancies that have chromosomal translocations.",133662,DMP,Drug Discovery and Molecular Pharmacology Study Section,,2,318513,
7809589,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA134014-02,,NCI:311223;,2010,NATIONAL CANCER INSTITUTE,,INDIANAPOLIS,UNITED STATES,SURGERY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"TOULOUKIAN, CHRISTOPHER E.;",8891882;,5R01CA134014,04/22/2009,02/28/2014,"5,6-dihydroxyindole-2-carboxylic acid oxidase; ATGN; Activated Lymphocyte; Adoptive Transfer; Advanced Cancer; Advanced Malignant Neoplasm; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Antigens; Antigens, Differentiation; Antineoplastic Vaccine; Applications Grants; Arm; Autoantigens; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; Autologous Antigens; B-Protein; Bears; Blast Transformation; Blastogenesis; Blood leukocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cancer Treatment; Cancer Vaccines; Cancers; Catalase B; Cells; Cells, CD4; Characteristics; DHI2C oxidase; DHICA oxidase; Data; Development; Differentiation Antigens; Differentiation Markers; Effectiveness; Engraftment; Event; Experimental Designs; Exposure to; Frequencies (time pattern); Frequency; Gene Inactivation; Gene Silencing; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Modified; Gene-Tx; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Genetic Intervention; Glycoprotein 75; Goals; Grant Proposals; Grants, Applications; HLA-DR4; HLA-DR4 Antigen; Human; Human, General; IL-7; IL7 Protein; ITX; Immune; Immune Escape, Tumor; Immune Tolerance; Immune response; Immune system; Immunization; Immuno-Chemotherapy; Immunochemotherapy; Immunologic Stimulation; Immunologic Tolerance; Immunological Stimulation; Immunologically Directed Therapy; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Immunotherapy; Immunotherapy, Cancer, General; Infusion; Infusion procedures; Interleukin 7 Precursor; Interleukin-7; Intervention, Genetic; Kinetic; Kinetics; Knock-out; Knockout; LYT3; Lead; Length of Life; Leukocytes; Longevity; Lymphoblast Transformation; Lymphocyte; Lymphocyte Activation; Lymphocyte Function; Lymphocyte Stimulation; Lymphocyte Transformation; Lymphocytic; Lymphopoietin-1; MHC Class II; MHC Class II Genes; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Melanoma; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marker Antigens; Markers, Differentation; Marrow leukocyte; Mediating; Metastatic Melanoma; Mice; Modeling; Molecular Biology, Gene Therapy; Molecular Genetic; Molecular Genetics; Mother Cells; Murine; Mus; Patients; Pb element; Peripheral; Physiologic; Physiological; Play; Population; Position; Positioning Attribute; Progenitor Cell Transplantation; Progenitor Cells; Proteins; Receptors, Antigen, T-Cell; Research Proposals; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Thymus; Role; Running; Self Tolerance; Self-Antigens; Sensitization, Immunologic; Sensitization, Immunological; Stem Cell Transplantation; Stem cell transplant; Stem cells; Surface; System; System, LOINC Axis 4; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; TRP-1; TRP-1 protein, tyrosinase-related; TRP1 protein, tyrosinase-related; TYRP; TYRP1; TYRP1 protein, human; Technology; Testing; Therapeutic; Therapy, DNA; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Transplantation; Tumor Escape; Tumor Immunity; Tyrosinase related protein-1; Tyrosinase-Related Protein 1; Upper arm; Ursidae; Ursidae Family; Vaccination; Vaccines, Neoplasm; Vaccines, Tumor; Vitiligo; White Blood Cells; White Cell; anticancer therapy; base; body system, allergic/immunologic; brown locus protein, human; cancer immunotherapy; cancer therapy; clinical applicability; clinical application; cytokine; design; designing; dihydroxyindole-carboxylic acid oxidase; experiment; experimental research; experimental study; gene product; gene therapy; genetic therapy; glycoprotein-75, human; gp75 TRP-1, brown protein, human; heavy metal Pb; heavy metal lead; helper T cell; host response; human TYRP1 protein; immune system tolerance; immune therapy; immune unresponsiveness; immunogen; immunogenicity; immunological paralysis; immunoresponse; improved; innovate; innovation; innovative; life span; lifespan; lymph cell; malignancy; melanocyte; melanoma; melanoma antigen gp75, human; model organism; neoplasm/cancer; new therapeutics; next generation therapeutics; novel; novel therapeutics; organ system, allergic/immunologic; public health relevance; research study; self recognition (immune); social role; thymus derived lymphocyte; transplant; tumor; tumor eradication; tyrosinase-related protein; tyrosinase-related protein 1, human; white blood cell; white blood corpuscle",Durable CD4+ T-cell Tumor Immunity Following Gene-modified HPSC," Project Narrative: This research proposal builds upon existing technologies and treatments in gene-therapy and immunotherapy for patients with cancer and metastatic melanoma in particular. Here we demonstrate the development of a model in which we successfully reconfigure the immune system with a specific high-frequency white blood cell that is capable of recognizing a key protein found on the surface of melanoma. We then propose experiments designed to better understand the therapeutic implications of this model, improve its overall effectiveness, and study its mechanisms-of-action.",134014,CII,Cancer Immunopathology and Immunotherapy Study Section,,2,311223,
7789615,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA134571-02,,NCI:261450;,2010,NATIONAL CANCER INSTITUTE,,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"SOUZA, RHONDA F (contact);SPECHLER, STUART JON;",1972113 (contact);7067670;,5R01CA134571,04/01/2009,01/31/2014,"(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid; 21+ years old; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; Acids; Acids, Bile; Adenocarcinoma; Adenocarcinoma Cell; Adenocarcinoma of the Esophagus; Adenoma, Malignant; Adult; Affect; American; Apoptosis; Apoptosis Pathway; Apoptotic; Autoregulation; B-Protein; Barrett Esophagus; Barrett Syndrome; Barrett Ulcer; Benign; Bile Acids; Bile Reflux; Body Tissues; Cancer Induction; Cancers; Catalase B; Cell Death, Programmed; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Survival; Cell Viability; CellLine; Cells; Cellular Proliferation; Chemopreventive; Chemopreventive Agent; Cholan-24-oic acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7beta)-; Clinical; Clinical Data; Clinical Research; Clinical Study; Columnar Epithelial-Lined Lower Esophagus; Columnar-Lined Esophagus; DNA Damage; DNA Injury; Data; Deoxycholic Acid; Deoxyursocholic Acid; Desoxycholic Acid; Development; Dihydroxycholanoic Acid; Disease; Disorder; Epithelial; Epithelial Cells; Esophageal; Esophageal Adenocarcinoma; Esophageal Neoplasms; Esophageal Neoplasms, Benign and Malignant; Esophageal Reflux; Esophageal Squamous Cell; Esophageal Tumor; Esophagus; Esophagus Neoplasm; Event; Exposure to; Frequencies (time pattern); Frequency; GERD; Gastric Juice; Gastro-oesophageal Reflux; Gastroesophageal Reflux; Gastroesophageal reflux disease; Gastrointestinal Tract, Esophagus; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Glycoprotein 75; Growth; HCL; Homeostasis; Human; Human, Adult; Human, General; Hydrochloric Acid; Immunoglobulin Enhancer-Binding Protein; In Vitro; Incidence; Intervention; Intervention Strategies; Intestinal; Intestines; Laboratories; Literature; Malignant Glandular Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Metaplasia; Metaplastic; Metaplastic Cell; Metaplastic Change; Metaplastic Columnar Cell; Metaplastic Epithelial Cell; Metaplastic Squamous Cell; Modeling; Molecular; Muriatic Acid; Mutation; NF-kB; NF-kappa B; NF-kappaB; NFKB; Neoplasms; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Pathogenesis; Pathway interactions; Patients; Physiological Homeostasis; Play; Predisposition; Prevention strategy; Preventive strategy; Process; Proliferating; Proteins; Proton Pump Inhibitors; Public Health; Publishing; Pump; Reflux; Research Specimen; Resistance; Risk Factors; Role; SUBGP; Signal Pathway; Signal Transduction Pathway; Specimen; Squamous Cell; Squamous Epithelium; Subgroup; Susceptibility; TRP-1; TYRP; TYRP1; TYRP1 protein, human; Technology; Telomerase; Tissue Growth; Tissues; Transcription Factor NF-kB; Tumor of the Esophagus; Tumors; Tyrosinase-Related Protein 1; Ursacholic Acid; Ursodeoxycholic Acid; Ursodiol; adult human (21+); anticarcinogenic; bowel; brown locus protein, human; cancer prevention; cancer progression; carcinogenesis; cultured cell line; disease/disorder; gene product; genome mutation; glycoprotein-75, human; gp75 TRP-1, brown protein, human; human TYRP1 protein; in vivo; inhibitor; inhibitor/antagonist; interventional strategy; irradiation; kappa B Enhancer Binding Protein; malignancy; melanoma antigen gp75, human; molecular marker; neoplasia; neoplasm progression; neoplasm/cancer; neoplastic; neoplastic growth; neoplastic progression; nuclear factor kappa beta; ontogeny; pathway; prevent; preventing; protein expression; public health medicine (field); public health relevance; repair; repaired; resistant; response; retrograde bile flow; social role; tumor; tumor growth; tumor progression; tyrosinase-related protein 1, human",Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus, Project Narrative The relevance to public health is the identification of specific molecular markers that can be used to select a subset of our many patients with gastroesophageal reflux disease who might benefit from aggressive anti- reflux therapies to prevent the development of Barrett's esophagus as well as to select a subgroup of patients with Barrett's esophagus who would benefit most from interventions to prevent esophageal adenocarcinoma.,134571,ZRG1,Special Emphasis Panel,,2,261450,
7759115,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA134991-02,,NCI:325775;,2010,NATIONAL CANCER INSTITUTE,,DALLAS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"CHEN, DAVID J;",1861799;,5R01CA134991,04/01/2009,01/31/2014,"Aberrant Chromosome; Abnormalities, Chromosomal; Affect; Alanine; Alanine, L-Isomer; Antimorphic mutation; Aspartic Acid; Assay; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Cancers; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromatin; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Connective Tissue Sarcoma; Cytogenetic Aberrations; Cytogenetic Abnormalities; DNA; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Helicases; DNA Injury; DNA Repair; DNA Unwinding Proteins; DNA unwinding enzyme; DNA- PKcs protein; DNA-Activated Protein Kinase Catalytic Subunit; DNA-PK; DNA-PKcs; DNA-activated protein kinase; DNA-dependent protein kinase; DNA-dependent protein serine-threonine kinase; DNAPK; DNPK1; Deoxyribonucleic Acid; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Double Strand Break Repair; EC 2.7; Electromagnetic, Laser; Epithelial; Event; Exonuclease; Family; Family member; Fibroblasts; G22P2; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genomics; HYRC1; Human; Human, General; Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1; I-SceI; In Vitro; Interruption; Kinases; Kinetic; Kinetics; Knockout Mice; Ku Antigen, 80-Kd Subunit Gene; Ku80; L-Alanine; L-Aspartic Acid; Laboratories; Lasers; Lead; Life; Maintenance; Maintenances; Malignant Neoplasms; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Soft Tissue; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mesenchymal Cell Neoplasm; Mesenchymal Cell Tumor; Mesenchymal Neoplasm; Mesenchymal Tumor; Mice; Mice, Knock-out; Mice, Knockout; Murine; Mus; Mutate; Mutation; NHEJ; Non-Homologous End Joining; Nonhomologous DNA End Joining; Null Mouse; PRKDC; Pathway interactions; Patients; Pb element; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Process; Progeria, Adult; Protein Family; Protein Phosphorylation; RECQ3 protein, human; RECQL2 protein, human; Radiation, Laser; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Recruitment Activity; Reporter; Research; Risk; Roentgen Rays; Role; SCID protein; Sarcoma of the Soft Tissue and Bone; Sarcoma, Soft Tissue; SceI endonuclease; Site; Study Section; Symptoms; System; System, LOINC Axis 4; Telomere Maintenance; Testing; Transphosphorylases; Unscheduled DNA Synthesis; WRN Protein; WRN protein, human; Werner Syndrome; Werner Syndrome Protein; Werner syndrome helicase, human; Werner's syndrome; X-Radiation; X-Rays; XRCC5; XRCC5 gene; XRCC7; XRCC7 protein; Xrays; age dependent; age related; base; cell imaging; cellular imaging; cultured cell line; early onset; endo.SceI; endodeoxyribonuclease Sce I; endodeoxyribonuclease SceI; experience; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; helicase; homologous recombination; human WRN protein; in vivo; kinase inhibitor; malignancy; meganuclease I-SceI; mutant; neoplasm/cancer; p350; p460 protein; pathway; polypeptide; protein protein interaction; public health relevance; recruit; repair; repaired; research study; response; sarcoma; social role; spatial relationship",Functions of WRN in Response to DNA Double-Strand Breaks," Werner Syndrome (WS) is an autosomal recessive condition characterized by an early onset of age-related symptoms. WS patients also experience an increased risk of rare non-epithelial cancers, especially mesenchymal neoplasms such as sarcomas. WRN, the protein defective in WS is involved in maintenance of genomic integrity and DNA damage repair. To understand the function of WRN in DNA damage response, we proposed to (i) determine the mechanism by which WRN is recruited to the sites of DNA damage in vivo, (ii) find out kinases that are responsible for WRN phosphorylation and (iii) determine the biological significance of WRN phosphorylation in the process of DNA double strand break repair mediated through non- homologous end joining and/or homologous recombination. The results obtained with these experiments will further elucidate the mechanism by which WRN contributes in genome maintenance, cancer and DNA repair.",134991,CE,Cancer Etiology Study Section,,2,325775,
7777362,R01,CA,5,,02/01/2010,12/31/2010,PA-07-070,5R01CA135061-02,,NCI:344450;,2010,NATIONAL CANCER INSTITUTE,,BRONX,UNITED STATES,PATHOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"HAZAN, RACHEL B;",2272271;,5R01CA135061,03/01/2009,12/31/2013,"(2,6)-sialyl T antigen; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Adhesion Molecule; Adhesions; Adhesives; Basement membrane; Bittner Virus; Cadherins; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Chimera; Chimera organism; Data; Disease; Disorder; Drugs; Endothelium, Vascular; Enzymes; Event; Exhibits; Extracellular Signal-Regulated Kinase Gene; Extravasation; FGF-R; FGFBR; FGFR; FGFR1; FGFR1 gene; FLG Gene; FLT2 Gene; FMS-Like Gene; FMS-Like Tyrosine Kinase 2 Gene; Fibroblast Growth Factor Receptor 1 Gene; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Gelatinase B; Genes; Genetic Alteration; Genetic Change; Genetic defect; In Vitro; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Leakage; Liver Cell Adhesion Molecules; Lung; MAP Kinase Gene; MAP2K1; MAP2K1 gene; MAPK; MAPKK1; MEK1; MKK1; MMP-9; MMP-9 Protein; MMP9; MMTV; Macrophage Gelatinase; Malignant Cell; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer Virus; Mammary Tumor Virus, Mouse; Matrix Metalloproteinase-9; Mediating; Medication; Metallopeptidases; Metalloproteases; Metalloproteinases; Metastasis; Metastasis to the Lung; Metastasize; Metastatic Neoplasm; Metastatic Neoplasm to the Lung; Metastatic Tumor; Metastatic Tumor to the Lung; Metastatic to; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Gene; Modeling; Motility; Motility, Cellular; Mouse Mammary Tumor Virus; Murine; Mus; Mutation; N-Cadherin; Neoplasm Metastasis; Oncogenes; Outcome; PRKMK1; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Plant Embryos; Play; Polyoma; Polyoma Viruses; Polyomavirus; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Publishing; Reagent; Receptors, FGF; Relative; Relative (related person); Respiratory System, Lung; Role; ST antigen; Secondary Neoplasm; Secondary Tumor; Seeds; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spillage; T Antigens; Testing; Therapeutic; Transforming Genes; Transgenic Mice; Transgenic Organisms; Tumor Cell; Tumor Cell Migration; Type V Collagenase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Endothelium; Viral T Antigens; Viral Tumor Antigens; Virus Transforming Antigens; Zygotes, Plant; base; biological signal transduction; cancer cell; cancer metastasis; cell adhesion protein; cell motility; design; designing; disease/disorder; drug/agent; epithelial to mesenchymal transition; extracellular; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; inhibitor; inhibitor/antagonist; insight; interventional strategy; kinase inhibitor; liver cell adhesion molecule; malignant breast neoplasm; mammary epithelium; metalloproteinase (general); migration; milk agent; mouse model; mutant; neoplastic cell; novel; overexpression; pathway; public health relevance; pulmonary; pulmonary metastasis; s-T antigen; seed; sialosyl-T antigen; slug; social role; transcription factor; transgenic; tumor","EMT, Extravasation and metastasis by N-Cadherin signaling","  Project Narrative  We found that the EMT transcription factor, Slug, is upregulated in tumors and metastases in which N- cadherin is upregulated. We believe that N-cadherin signaling through the FGF receptor induces a cascade of events that leads to Slug induction, extravasation and metastasis. We will rule out the role of N-cadherin adhesion in this process. We believe these studies will broaden our understanding of mechanisms that regulate breast cancer metastasis and will provide insights into therapeutic application.",135061,TCB,Tumor Cell Biology Study Section,,2,344450,
7795871,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA135087-02,,NCI:243605;,2010,NATIONAL CANCER INSTITUTE,,NORFOLK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,058625146,US,VA,235011980,EASTERN VIRGINIA MEDICAL SCHOOL,"DRAKE, RICHARD R;",1864034;,5R01CA135087,03/27/2009,01/31/2013,"Acid phosphatase isoenzyme, prostatic fraction; Archives; Assay; Benign; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biopsy; Biotechnology; Blinded; Blood Serum; Body Tissues; Cancer Detection; Cancer of Prostate; Cancers; Carbohydrates; Chemical Fractionation; Chromatography, Exclusion; Chromatography, Gel; Chromatography, Gel Permeation; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinic; Clinical; Cognitive Discrimination; Collection; Complex; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxygalactose; Detection; Development; Diagnostic; Discrimination; Discrimination (Psychology); Disease; Disorder; EC 3.4.21.34; ELISA; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; FRACN; Fletcher Factor; Fluids and Secretions; Fractionation; Fractionation Radiotherapy; Fucose; Gel; Gel Chromatography; Gel Filtration; Gel Filtration Chromatography; Genital System, Male, Prostate; Glycans; Glycopeptides; Glycoproteins; Goals; HPLC; High Pressure Liquid Chromatography; High-Risk Cancer; History; Human Prostate; Human Prostate Gland; Individual; Institutes; Instrumentation, Other; Ions; KLK3; Kallikrein 3; Lectin; Link; Liquid substance; MALD-MS; MALDI; MALDI-MS; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mass Spectrum; Mass Spectrum Analysis; Massage; Metabolic Glycosylation; Methods; Methods and Techniques; Methods, Other; Molecular Interaction; N-Acetylneuraminic Acids; P-30 Antigen; PAcP protein; Pathology; Patients; Peptides; Phenotype; Photometry/Spectrum Analysis, Mass; Plasma Kallikrein Precursor; Plasma Prekallikrein; Plasma, Seminal; Polysaccharides; Principal Investigator; Procedures; Process; Property; Property, LOINC Axis 2; Prostate; Prostate CA; Prostate Cancer; Prostate Disease; Prostate Gland; Prostate Specific Antigen Preproprotein; Prostate-Specific Antigen; Prostatectomy; Prostatic; Prostatic Acid Phosphatase; Prostatic Cancer; Prostatic Diseases; Prostatic Gland; Proteins; Proteomics; Publishing; Reaction; Recording of previous events; Research; Risk; Sampling; Science of Virology; Screening procedure; Semen; Semenogelase; Seminal Plasma; Seminal fluid; Seminin; Serum; Severity of illness; Sialic Acids; Site; Slice; Source; Specialist; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Speed; Speed (motion); Spottings; Stratification; Structure; Surface; Techniques; Testing; Tissues; Translational Research; Translational Research Enterprise; Translational Science; Tripcellim; Trypsin; Urinary System, Urine; Urine; Validation; Virginia; Virology; advanced disease; alpha-Fucose; base; biobank; biomarker; cancer risk; carbohydrate structure; clinical assay development; clinical data repository; clinical data warehouse; cohort; data repository; digital; disease severity; disease/disorder; early detection; experiment; experimental research; experimental study; fluid; gamma-Seminoprotein; gene product; glycosylation; hK3 Kallikrein; improved; instrumentation; kininogenin; liquid; malignancy; massage therapy; matrix assisted laser desorption ionization; molecular marker; neoplasm/cancer; new diagnostics; next generation diagnostics; novel diagnostics; point-of-care diagnostics; prospective; prostate disorder; prostatic fraction Acid phosphatase isoenzyme; public health relevance; rectal; relational database; research study; sample collection; screening; screenings; specimen collection; translation research enterprise; virology",Glycan Biomarkers of Prostate Cancer in Prostatic Fluids," The current strengths and limitations of the PSA serum test for early detection and treatment of prostate cancers are well documented, and it is clear new diagnostic biomarkers are needed for this disease. We propose to characterize cancer specific changes in the glycan components of proteins in fluids secreted by the prostate. Identification of these molecular markers will improve prostate cancer detection and risk stratification prior to biopsy and prostatectomy procedures.",135087,CBSS,Cancer Biomarkers Study Section,,2,243605,
7752847,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA135362-02,,NCI:253980;,2010,NATIONAL CANCER INSTITUTE,,MIAMI,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"HARHAJ, EDWARD W;",2103442;,5R01CA135362,04/01/2009,01/31/2014,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; APF-1; ATF; ATP-Dependent Proteolysis Factor 1; Adult; Adult T-Cell Leukemia-Lymphoma Virus I; Automobile Driving; Binding; Binding (Molecular Function); Binding Proteins; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cancer Biology; Cancers; Cell Communication and Signaling; Cell Death; Cell Line, Transformed; Cell Signaling; Cell Survival; Cell Viability; Cells; Cells, CD4; Collaborations; Complex; Data; Deubiquitination; Disease; Disorder; Drivings, Automobile; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Enzymes; Event; Family; Feedback; Future; Gene Expression; Genes; Genes, Viral; Genome; Goals; Golgi; Golgi Apparatus; Golgi Complex; Golgi Targeting; HMG-20; HTLV Viruses; HTLV-1; HTLV-I; HTLV-I tax Gene Product; HTLV-I tax Protein; HTLV1; High Mobility Protein 20; Host Factor; Host Factor Protein; Human T-Cell Leukemia Virus Type I tax Gene Product; Human T-Cell Leukemia Virus Type I tax Protein; Human T-Cell Leukemia Viruses; Human T-Cell Leukemia-Lymphoma Viruses; Human T-Lymphotropic Virus, Type I; Human T-lymphotropic virus 1; Human, Adult; Immunoglobulin Enhancer-Binding Protein; Integration Host Factors; Intracellular Communication and Signaling; Investigation; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; L-Lysine; LPS; Lead; Leukemia Viruses, Human T-Cell; Leukemia, T-Cell; Ligand Binding Protein; Light; Link; Lipopolysaccharides; Lymphocytic Leukemia, T-Cell; Lysine; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Macropain; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Mediating; Molecular; Molecular Interaction; Molecular Target; Movement; Multicatalytic Proteinase; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Oncogene Products; Oncogene Proteins; Oncoproteins; PRKM8; Pb element; Phosphotransferases; Photoradiation; Play; Polyubiquitin; Polyubiquitination; Principal Investigator; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteosome; Research; Role; SAPK1; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Study Section; T-Cell Leukemia; T-Cell Leukemia Virus I, Human; T-Cells; T-Lymphocyte; T-Lymphocytic Leukemia; T4 Cells; T4 Lymphocytes; Taxes; Thymus-Dependent Lymphocytes; Trans-Activator Protein, HTLV-I; Transcription Factor NF-kB; Transformed Cell Line; Transphosphorylases; Ubiquitilation; Ubiquitin; Ubiquitin, poly-; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Unspecified Human T-Cell Leukemia Virus; Viral; Viral Genes; Virus-HTLV-I; Virus-HTLV-Unspecified; activating transcription factor; adult human (21+); base; biological signal transduction; body movement; cell immortalization; cell transformation; cytokine; disease/disorder; driving; gene product; heavy metal Pb; heavy metal lead; helper T cell; human T cell lymphoma virus I; human T cell lymphoma virus type I; human T cell lymphotropic virus 1; human T cell lymphotropic virus type 1; human T lymphotropic virus I; human T-cell leukemia virus type 1; intervention design; kappa B Enhancer Binding Protein; malignancy; multicatalytic endopeptidase complex; mutant; necrocytosis; neoplasm/cancer; novel; nuclear factor kappa beta; protein degradation; protein function; public health relevance; social role; therapy design; thymus derived lymphocyte; transcription factor; transformed cells; treatment design; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",Mechanisms of HTLV-I Tax-mediated NF-kB activation,"  The HTLV-I Tax oncoprotein is a potent activator of the NF-kB/Rel transcription factor family. Tax requires NF-kB for the immortalization of T cells, and NF-kB is also required for the survival of HTLV-1 transformed cell lines. The focus of the proposal is to determine the molecular mechanisms used by Tax to activate NF-kB, specifically we will further establish the determinants of Tax ubiquitination and examine the role of Tax interaction with the cellular protein TAX1BP1.",135362,CAMP,Cancer Molecular Pathobiology Study Section,,2,253980,
7760126,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA135554-08,,NCI:401310;,2010,NATIONAL CANCER INSTITUTE,,MEMPHIS,UNITED STATES,,09,067717892,US,TN,38105,ST. JUDE CHILDREN'S RESEARCH HOSPITAL,"BAKER, SUZANNE J;",1928604;,5R01CA135554,07/03/2002,01/31/2013,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Assay; Astrocytes; Astrocytic Neoplasm; Astrocytic Tumor; Astrocytoma; Astrocytoma, Grade IV; Astrocytus; Astroglia; Astroglioma; BZS; Bioassay; Biologic Assays; Biological Assay; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Cancer Genes; Cancer-Promoting Gene; Cancers; Candidate Disease Gene; Candidate Gene; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Culture Techniques; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Migration; Cellular Proliferation; Chromosomal, Gene, or Protein Abnormality; Chromosome 10; Chromosomes, Human, Pair 10; Cytogenetic or Molecular Genetic Abnormality; Defect; Development; Dysfunction; Encephalon; Encephalons; Feedback; Functional disorder; Generalized Growth; Genes; Genes, p53; Genetic Abnormality; Genetic Alteration; Genetic Change; Genetic defect; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Glioma, Astrocytic; Gliomagenesis; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Hereditary; Histopathology; Human; Human, General; Imagery; In Vitro; Incidence; Inherited; Intracellular Communication and Signaling; MHAM; MMAC1; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Modeling; Molecular; Molecular Abnormality; Motility; Motility, Cellular; Murine; Mus; Mutate; Mutation; Mutation Analysis; NRVS-SYS; Neoplasms; Neoplasms of Neuroglia; Nervous System; Nervous System, Brain; Nervous system structure; Neural Stem Cell; Neuroglial Neoplasm; Neuroglial Tumor; Neurologic Body System; Neurologic Organ System; Oncogenes; Oncogenesis; Oncogenic; Organ System; Outcome; P53; PI-3 Kinase; PI-3K; PI3-Kinase; PI3-Kinase P110 Subunit Alpha; PI3CG; PI3KGamma; PI3k; PIK3; PIK3CA; PIK3CA gene; PIK3CA protein, human; PIK3CG; PIK3CG gene; PTEN; PTEN gene; PTEN1; Pathway interactions; Phosphatase and Tensin Homolog; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinase, Catalytic Subunit Gene; Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Alpha; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha Isoform; Phosphoinositide 3-Hydroxykinase; Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide; Physiologic; Physiological; Physiopathology; Play; Preclinical Testing; PtdIns 3-Kinase; PtdIns-3-Kinase p110; Public Health; Rapamune; Rapamycin; Regulation; Relative; Relative (related person); Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Testing; Therapeutic; Therapeutic Intervention; Tissue Growth; Transforming Genes; Tumor Cell; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Tumors; Tumors of Neuroglia; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Visualization; biological signal transduction; body system; cell motility; design; designing; experiment; experimental research; experimental study; genome mutation; glioblastoma multiforme; glioma genesis; human PIK3CA protein; improved; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; insight; intervention therapy; loss of function; malignancy; mouse model; mutant; neoplasia; neoplasm/cancer; neoplastic cell; neoplastic growth; nerve stem cell; neural progenitor cells; neuronal progenitor; neuronal progenitor cells; novel; ontogeny; p110-Alpha; p110-Alpha Gene; pathophysiology; pathway; phosphoinositide-3-kinase, catalytic, alpha polypeptide, human; public health medicine (field); recombinase; research study; resistant; response; social role; spongioblastoma multiforme; tumor; tumor suppressor; tumorigenesis; tumorigenic; tumors in the brain",Pten and P13K regulation of growth and neoplasia in the brain,,135554,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,8,401310,
7793563,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA135559-02,,NCI:303988;,2010,NATIONAL CANCER INSTITUTE,,OKLAHOMA CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"ANANT, SHRIKANT ;",1924322;,5R01CA135559,04/01/2009,01/31/2014,"3' Untranslated Regions; 3'UTR; Affinity; Aminoacetic Acid; Anchorage-Independent Growth; Anionic Neutrophil-Activating Peptide; Anthelone U; Apoptosis; Apoptosis Pathway; Athymic Nude Mouse; Behavior; Binding; Binding (Molecular Function); Binding Sites; C-terminal; COX-2 protein; COX2; COX2 enzyme; Cancer Model; CancerModel; Cancers; Cause of Death; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cells; Cellular Oncogene; Chemotactic Factor, Macrophage-Derived; Chemotactic Factor, Neutrophil; Chemotactic Factor, Neutrophil, Monocyte-Derived; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Combining Site; Consensus; Cyclo-Oxygenase-2; Cyclooxygenase; Decay, mRNA; Deletion Mutation; Disease; Disorder; EGF; Elements; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Epithelial Cells; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; GCP-IL-8; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Generalized Growth; Genetics-Mutagenesis; Glycine; Goals; Granulocyte Chemotactic Peptide-Interleukin-8; Growth; Hand; Heterograft; Human Urinary Gastric Inhibitor; Interleukin-8; Intestinal; Intestines; L-Serine; L-Threonine; Lead; Leukocyte Adhesion Inhibitor; M Phase; M phase (cell cycle); Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Manuscripts; Mediating; Messenger RNA; Methods; Mice; Mice, Athymic; Mice, Nude; Micro RNA; MicroRNAs; Mitosis; Mitosis Stage; Mitotic; Modification; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; N-terminal; NH2-terminal; Neutrophil Activating Peptide; Neutrophil Activation Factor; Neutrophil Activation Peptide; Neutrophil-Activating Peptide, Lymphocyte-Derived; Neutrophil-Activating Peptide, Monocyte-Derived; Normal Cell; Nude Mice; Oncogenesis; Overexpression; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PTGS2; Pathway interactions; Pb element; Phenotype; Phosphorylation; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Process; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Binding; Protein Overexpression; Protein Phosphorylation; Proteins; Proto-Oncogenes; Publishing; Putative RNA-Binding Region; RAFT-1 gene product; RAFT1 protein, human; RAPT1 protein, human; RBD; RNA Binding; RNA Binding Domain; RNA Recognition Motif; RNA Sequences; RNA Stability; RNA, Messenger; RNA-Binding Proteins; RNP; RNP Domain; RNP Motif; RNP-1 Signature; RRM; Rapamycin Target Protein; Reactive Site; Ribonucleoproteins; Ribosomes; Role; Sequences, RNA; Serine; Signal Pathway; Site; Stability, mRNA; Threonine; Tissue Growth; Transcript; Transcription Activation; Transcriptional Activation; Translations; Transplantation, Heterologous; Tumor Cell; Tyrosine Phosphorylation Site; Ubiquitilation; Ubiquitination; Ubiquitinoylation; United States; Up-Regulation; Urogastrone; VEGFs; Vascular Endothelial Growth Factors; Vegf; Work; Xenograft; Xenograft procedure; Xenotransplantation; base; beta-Urogastrone; bowel; c-ONC; cancer cell; cyclo-oxygenase II; cyclooxygenase 2; deletion analysis; disease/disorder; experiment; experimental research; experimental study; gene product; genetic promoter element; heavy metal Pb; heavy metal lead; human FRAP1 protein; mRNA; mRNA Decay; mRNA Stability; mTOR; mTOR gene product; mTOR protein; malignancy; mammalian target of rapamycin (mTOR); miRNA; mutant; necrocytosis; neoplasm/cancer; neoplastic cell; notch; notch protein; notch receptors; novel; ontogeny; overexpress; overexpression; pathway; prostaglandin H synthase-2; protooncogene; public health relevance; rapamycin and FKBP12 target 1 protein, human; research study; social role; tumor; tumor xenograft; tumorigenesis; ubiquination; ubiquitin conjugation",RNA Binding Proteins in Cancer," Project Narrative Cancer is the leading cause of death in the United States. Understanding how the normal cell progresses to a cancer will aid in our developing novel therapies for this dreaded disease. We have identified a protein, RBM3 whose expression is increased in cancer cells. Overexpressing RBM3 protein causes a normal cell to become transformed into a cancer cell. Our current proposal deals with identifying mechanisms by which RBM3 expression is regulated, and also how RBM3 induces tumorigenesis. We expect that the work will lead to a better understanding of the tumorigenesis process which should subsequently lead to novel methods to stop or slow down tumorigenesis.",135559,CE,Cancer Etiology Study Section,,2,303988,
7742981,R01,CA,5,,01/29/2010,11/30/2010,PA-07-070,5R01CA136574-02,,NCI:336619;,2010,NATIONAL CANCER INSTITUTE,,STANFORD,UNITED STATES,BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"CHEN, JAMES K;",2447241;,5R01CA136574,12/01/2008,11/30/2013,"0-11 years old; 1,4-dihydropyridine; 21+ years old; Accounting; Adult; Affect; Amines; Assay; BCC; Basal cell carcinoma; Basiloma; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Body Tissues; Bone Formation; Brain; Breast; Cancer Treatment; Cancer of Brain; Cancer of Prostate; Cancers; Carcinoma, Basal Cell, Pigmented; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Child; Child Youth; Childhood Brain Neoplasm; Childhood Brain Tumor; Children (0-21); Collection; Coupled; Cultured Cells; DNA Binding; DNA Binding Interaction; Development; Dihydropyridines; Drosophila; Drosophila genus; Drugs; Elements; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelioma, Basal Cell; Erinaceidae; Evaluation; Event; Family; Fetal Development; Fetal development of the mammalian embryo or fetus; Fruit Fly, Drosophila; Future; Gastrointestinal Tract, Pancreas; Gene Expression; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic Transcription; Genetic defect; Genital System, Male, Prostate; Gleevec; Glivec; Goals; Growth; Gx Protein; Hedgehog (Hh) signal transduction pathway; Hedgehogs; High Throughput Assay; Human Prostate; Human Prostate Gland; Human, Adult; Human, Child; Individual; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Knowledge; Laboratories; Ligands; Link; Lung; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Brain; Malignant Tumor of the Prostate; Malignant neoplasm of brain; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammalia; Mammals; Mammals, General; Medical; Medication; Molecular; Mutation; Names; Nervous System, Brain; Oncogenesis; Oncogenic; Osteogenesis; Pancreas; Pancreas Adenocarcinoma; Pancreatic; Pancreatic Adenocarcinoma; Pathway interactions; Patients; Pattern; Pediatric Neoplasm of the Brain; Pediatric Tumor of the Brain; Pharmaceutic Preparations; Pharmaceutical Preparations; Position; Positioning Attribute; Process; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Proteins; RNA Expression; Receptor Protein; Reporting; Research; Respiratory System, Lung; SMO; SMO protein, human; SMOH; SMOH protein, human; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Skin; Skin Basal Cell Carcinoma; Smoothened; Smoothened Homolog; Specificity; Structure-Activity Relationship; Subcellular Process; Synthesis Chemistry; Synthetic Chemistry; Tissue Growth; Tissues; Transcription; Transcription, Genetic; Transmembrane Protein; Ulcer, Rodent; adult human (21+); analog; anticancer therapy; base; biological signal transduction; cancer initiation; cancer therapy; cellular targeting; chemical structure function; chemical synthesis; chemotherapy; children; computerized data processing; data processing; design; designing; dihydropyridine; drug/agent; effective therapy; fruit fly; gene product; genome mutation; hedgehog signal transduction; hedgehog signaling pathway; hh signal transduction; hh signaling pathway; high throughput screening; human SMO protein; in vivo; inhibitor; inhibitor/antagonist; insight; malignancy; medulloblastoma; mouse model; mutant; neoplasm/cancer; next generation; novel; ontogeny; pathway; patient population; pharmacophore; public health relevance; pulmonary; receptor; signal processing; small molecule; smoothened homolog (Drosophila), human; smoothened signaling pathway; structure function relationship; tool; transcription factor; tumor; tumorigenesis; tumorigenic; youngster",Hedgehog Pathway Blockade by Small-Molecule Gli Antagonists,,136574,DMP,Drug Discovery and Molecular Pharmacology Study Section,,2,336619,
7778929,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA136578-02,,NCI:351758;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"MUCCI, LORELEI ;",8652993;,5R01CA136578,03/03/2009,01/31/2014,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 5' Untranslated Regions; 5'UTR; ACRP30 protein; ARO; ARO1; Active Follow-up; Address; Adipose tissue; Affect; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Apoptosis; Apoptosis Pathway; Area; BMI percentile; BMI z-score; Blood Plasma; Body Weight Changes; Body mass index; Bone Metastasis; Bone cancer metastatic; Bony metastasis; CPT7; CPV1; CYAR; CYP17; CYP17A1; CYP17A1 gene; CYP19; CYP19A1; CYP19A1 gene; Cancer Genes; Cancer Prognosis; Cancer Staging; Cancer of Prostate; Cancer-Promoting Gene; Cancers; Castration; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cellular Proliferation; Cessation of life; Characteristics; Chemotherapy-Hormones/Steroids; Clinical; Collaborations; Communities; Coxa; DNA; Data; Death; Delta4-androsten-17beta-ol-3-one; Deoxyribonucleic Acid; Diagnosis; Diagnostic Neoplasm Staging; Disease; Disease Progression; Disorder; ER-BETA; ERB; ESR-BETA; ESR1; ESR1 gene; ESR2; ESR2 gene; ESRB; ESTRB; Endocrine Gland Secretion; Epitheliasin Gene; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Exhibits; FISH Technic; FISH Technique; FISH analysis; Family member; Fatty Tissue; Fluorescent in Situ Hybridization; Follow-Up Studies; Followup Studies; Forecast of outcome; Frequencies (time pattern); Frequency; Gene Fusion; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Transcription; Genital System, Male, Prostate; Gleason Grade; Gleason Grade for Prostate Cancer; Gleason Score; Gleason Score for Prostate Cancer; Gleason Sum; Gleason-SC; Gonadal Steroid Hormones; Growth; Health; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Heterogeneity; Hip; Hip region structure; Hormonal; Hormones; Human; Human Prostate; Human Prostate Gland; Human, General; Humulin R; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization, Fluorescence; Incidence; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Lead; Lifestyle Factors, Unspecified; Light; Link; METBL; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Measures; Medical; Metabolic Processes; Metabolism; Metastasis to bone; Metastatic Cancer to the Bone; Metastatic Neoplasm to the Bone; Metastatic Tumor to the Bone; Metastatic malignant neoplasm to bone; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NR3A1; NR3A2; Neoplasm Staging; Novolin R; Obesity; Oncogenes; Osseous metastasis; Outcome; P-450AROM; P450C17; PRSS10; Pathogenesis; Pathway interactions; Patient Selection; Pb element; Peptides; Photoradiation; Physicians; Plasma; Play; Production; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Neoplasia; Prostatic Neoplasms; Proteins; Public Health; Quetelet index; RNA Expression; Receptor Signaling; Regulation; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Risk; Role; S17AH; SHBG; SHBG gene; Secondary Prevention; Secondary cancer of bone; Secondary malignancy of bone; Secondary malignant neoplasm of bone; Serum, Plasma; Sex Hormone-Binding Globulin Gene; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal metastasis; Staging; Stimulus; Surgical Castration; T-Stage; TMPRSS2; TMPRSS2 gene; Testosterone; Therapeutic Androgen; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Intervention; Therapeutic Testosterone; Tissue Growth; Trans-Testosterone; Transcript; Transcription; Transcription, Genetic; Transforming Genes; Tumor Angiogenesis; Tumor Staging; Tumor Tissue; Tumor of the Prostate; Tumor stage; United States; Variant; Variation; Weight; Weight Change; Western World; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adipose; adiposity; apM-1 protein; apM1 (adipose-specific) protein; base; biobank; biological signal transduction; biomarker; bone neoplasm secondary; cancer progression; cohort; corpulence; corpulency; corpulentia; deprivation; disease/disorder; follow-up; gene function; gene product; gonadal steroids; heavy metal Pb; heavy metal lead; hormonal regulation; hormone regulation; improved; intervention therapy; lifestyle factors; mRNA Leader Sequences; malignancy; men; men's; necrocytosis; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; obese; obese people; obese person; obese population; ontogeny; outcome forecast; pathway; prospective; public health medicine (field); public health relevance; repository; response; sex steroid; social role; steroid hormone metabolism; transcription factor; tumor; tumor growth; tumor progression; waist circumference; white adipose tissue; yellow adipose tissue",Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression,,136578,EPIC,Epidemiology of Cancer Study Section,,2,351758,
7786282,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA136806-02,,NCI:450686;,2010,NATIONAL CANCER INSTITUTE,,PITTSBURGH,UNITED STATES,GENETICS,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MOORE, PATRICK S.;",1895910;,5R01CA136806,03/13/2009,01/31/2014,"(2,6)-sialyl T antigen; Affinity Chromatography; Antibodies; Antigen Targeting; Assay; Auditory Receptor Cell; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood Cells; Blotting, Southern; Breeding; C-terminal; Cancer Induction; Cancers; Carcinoma Cell; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cercopithecus pygerythrus; Chromatography, Affinity; Cutaneous Neuroendocrine Carcinoma; Cytosolic Protein Tyrosine Phosphastase; DNA blotting; Detection; Drug Evaluation, Preclinical; Drug Screening; Enhancers; Epidemiology; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; FISH Technic; FISH Technique; FISH analysis; Fluorescent in Situ Hybridization; Gene Expression; Generations; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Genome; Germany; Green Monkey; HPTPG; Human; Human, General; Immune Precipitation; Immunoblotting; Immunologic, Luciferase; Immunoprecipitation; In Situ Hybridization, Fluorescence; In Vitro; Insertional Mutagenesis; Intervening Sequences; Intracellular Communication and Signaling; Introns; Japan; Knockout Mice; Learning; Ligand Binding Protein; Luciferases; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mechanoreceptor Cell; Melanoma and Non-Melanoma Skin Cancer; Merkel Cell Tumor; Merkel Cells; Merkel cell cancer; Merkel cell carcinoma; Merkel's Receptor; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Model System; Models, Biologic; Molecular Interaction; Monkey, African Green; Murine; Mus; Mutagenesis, Insertional; Mutation; N-terminal; NH2-terminal; Neuroendocrine Carcinoma of the Skin; Null Mouse; Oncogene Products; Oncogene Proteins; Oncogenesis; Oncoproteins; P105-RB; P53; PP110; PTPG; PTPRG; PTPRG gene; PTPase; Patients; Pattern; Peripheral Blood Cell; Persons; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Plasmids; Play; Polyoma; Polyoma Viruses; Polyomavirus; Polyomavirus Infections; Polyomavirus macacae; Polyomavirus maccacae 1; Population; Preclinical Drug Evaluation; Prevention; Production; Protein Binding Domain; Protein Binding Motif; Protein C; Protein Tyrosine Phosphatase; Protein-Protein Interaction Domain; Proteins; Proteomics; R-PTP-GAMMA; RB1; RPTPG; Rb Gene Product; Rb Protein; Rb1 Gene Product; Receptor Protein; Reporter; Retinoblastoma Associated Protein; Retinoblastoma Protein; Rodent; Rodentia; Rodentias; Role; ST antigen; SV 40; SV 40 Virus; SV40; SV40 Virus; Signal Transduction; Signal Transduction Systems; Signaling; Simian Vacuolating Virus 40; Simian virus 40; Site; Skin Cancer; Skin Cancer, Including Melanoma; Soft Agar Assay; Southern Blotting; T Antigens; TP53; TP53 gene; TRP53; Trabecular Skin Carcinoma; Transgenic Mice; Tumor Protein p53 Gene; Tumor Suppressor Proteins; Tumor-Derived; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Vacuolating Agent; Viral Diseases; Viral T Antigens; Viral Tumor Antigens; Virus; Virus Diseases; Virus Integration; Virus Transforming Antigens; Viruses, General; advanced disease; affinity purification; biological signal transduction; carcinogenesis; cell transformation; cultured cell line; experiment; experimental research; experimental study; gene product; genome mutation; malignancy; neoplasm/cancer; novel; pRB; protein tyrosine phosphate phosphohydrolase; public health relevance; receptor; research study; s-T antigen; sialosyl-T antigen; social role; transformed cells; tumor; tumor suppressor; tumorigenesis; vacuolating virus; viral infection; virus infection",Role of a new polyomavirus in Merkel cell carcinoma," This proposal seeks to understand how Merkel cell virus (MCV) contributes to human cancers. MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses. This proposal will investigate similarities and differences between MCV T antigen and T antigen from other viruses as well as dysregulation of cellular proteins from MCV integration and T antigen expression. Finally, we seek to generate a model system for MCV tumorigenesis that will be useful for drug screening and prevention.",136806,CE,Cancer Etiology Study Section,,2,450686,
7805604,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA136829-02,,NCI:311960;,2010,NATIONAL CANCER INSTITUTE,,ANN ARBOR,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LUKER, GARY D;",1978317;,5R01CA136829,04/15/2009,01/31/2014,"Adhesions; Affect; Area; Binding; Binding (Molecular Function); Biochemical; Blood Circulation; Blood Vessels; Blood capillaries; Bloodstream; Body Tissues; Breast Cancer Cell; C-X-C Chemokine Receptor Type 4; CD184 Antigen; CXC-R4; CXCL12; CXCL12 gene; CXCR-4; CXCR4; CXCR4 Receptors; CXCR4 gene; Cancer Cell Growth; Cancer of Breast; Cancers; Capillaries; Capillary; Capillary, Unspecified; Cause of Death; Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cellular Adhesion; Chemoattractants; Chemokine (C-X-C Motif) Receptor 4; Chemokine, CXC Motif, Receptor 4; Chemotactic Factors; Chemotaxins; Circulation; Cytokines, Chemotactic; D2S201E; Devices; Disease; Disorder; Disseminated Malignant Neoplasm; Drug resistance; Endothelial Cells; Endothelium; Endothelium, Vascular; Engineering; Engineerings; Environment; FB22; Figs; Figs - dietary; Fusin; Genetic Alteration; Genetic Change; Genetic defect; HM89; HSY3RR; Homing; Homologous Chemotactic Cytokines; Human Breast Cancer Cell; Image; Intercrines; Intracellular Communication and Signaling; Knowledge; LAP3; LCR1; LESTR; LPS-Associated Protein 3; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mechanical Stress; Mechanics; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Tumor; Methods; Microfluidic; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Microfluidics; Modeling; Molecular; Molecular Interaction; Mutation; NPY3R; NPYR; NPYRL; NPYY3R; Neoplasm Metastasis; Neuropeptide Y Receptor Y3; One Step; One-Step dentin bonding system; Organ; PBSF; Patients; Physiologic; Physiological; Primary Neoplasm; Primary Tumor; Receptor Protein; Receptor, LESTR; Regulation; Research; SCYB12; SDF-1 Receptor; SDF-1A; SDF-1B; SDF1; SDF1/PBSF Receptor CXCR4; SDF1A; SDF1B; SIS cytokines; Secondary Neoplasm; Secondary Tumor; Series; Seven-Transmembrane-Segment Receptor, Spleen; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solid; Stimulus; Stress; Stress, Mechanical; Stromal Cell-Derived Factor 1 Receptor; System; System, LOINC Axis 4; TLSF-A; TLSF-B; TPAR1; Testing; Therapeutic; Time; Tissues; Tumor Cell; Tumor Cell Migration; Validation; Vascular Endothelium; Vascular System; anticancer research; biological signal transduction; cancer cell; cancer metastasis; cancer research; cancer type; capillary; chemoattractant cytokine; chemokine; chemokine receptor; complement chemotactic factor; cultured cell line; design; designing; disease/disorder; drug resistant; genome mutation; imaging; innovate; innovation; innovative; insight; malignancy; malignant breast neoplasm; meetings; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; novel therapeutics; prevent; preventing; public health relevance; receptor; resistance to Drug; resistance to therapy; resistant to Drug; resistant to therapy; shear stress; therapeutic target; therapy resistant; trafficking; vascular",Microfluidic Models of Metastatic Cancer," Lay Summary: This research will develop new, physiologic cell culture models of blood vessels to study interactions between circulating breast cancer cells and vascular endothelium during metastasis. These models should greatly advance our knowledge of metastatic disease and enable more rapid testing and validation of new cancer therapeutics to treat or prevent metastatic disease.",136829,ISD,Instrumentation and Systems Development Study Section,,2,311960,
7771764,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA136934-02,,NCI:323700;,2010,NATIONAL CANCER INSTITUTE,,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"YANG, YIPING ;",6790092;,5R01CA136934,03/01/2009,01/31/2014,"Allogenic; Antigen Presentation Pathway; Antigen Processing and Presentation; Antineoplastic Vaccine; Autologous; Biological Function; Biological Process; CD8; CD8B; CD8B1; CD8B1 gene; Cancer Vaccines; Cancers; Cell Transplants; Cells; Dendritic Cell Vaccine; Dendritic Cells; Detectable Residual Disease; Elements; Generations; Hematopoietic; IFN; Immune; Immune system; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immuno-Chemotherapy; Immunochemotherapy; Immunosuppressants; Immunosuppressive Agents; Immunotherapeutic agent; Immunotherapy, Cancer, General; Inflammatory; Interferon Type I; Interferons; LYT3; Lead; Learning; Life; Ligands; Malignant Neoplasms; Malignant Tumor; Mediating; Minimal Residual Disease; Myeloablative Chemotherapy; Natural Immunity; Neoplasm, Residual; Pathway interactions; Pb element; Poxvirus officinale; Production; Progenitor Cell Transplantation; Receptor Signaling; Recovery; Regulatory T-Lymphocyte; Residual Neoplasm; Stem Cell Transplantation; Stem cell transplant; T memory cell; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; TIL4; TLR protein; TLR2; TLR2 gene; Testing; Thymus-Dependent Lymphocytes; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; Transplantation; Transplants, Cell; Tumor Antigens; Tumor Immunity; Tumor-Associated Antigen; Vaccination; Vaccines; Vaccines, Neoplasm; Vaccines, Tumor; Vaccinia virus; Veiled Cells; Work; base; body system, allergic/immunologic; cancer immunotherapy; cytokine; design; designing; heavy metal Pb; heavy metal lead; immunologic preparation; immunosuppressive; immunotherapeutics; in vivo; malignancy; memory T lymphocyte; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathway; public health relevance; recombinant vaccinia virus; response; thymus derived lymphocyte; transplant; tumor; tumor-specific antigen",Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant," Project Narrative One major hurdle in cancer immunotherapy even in the setting of stem cell transplantation is the presence of immunosuppressive regulatory T cells. Therefore, the key is to develop cancer vaccines capable of overcoming regulatory T cell-mediated suppression and effectively activate anti-tumor immunity. The proposed work will lead to the idenfication of critical factors required for ovecoming regulatory T cell-mediated suppression and promoting anti-tumor T cell immunity post-transplant, and in turn will help us design new generations of effective vaccines for treating cancer in the setting of stem cell transplant.",136934,CII,Cancer Immunopathology and Immunotherapy Study Section,,2,323700,
7807116,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA137059-02,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"ZAL, TOMASZ ;",7346224;,5R01CA137059,05/01/2009,02/28/2014,"ATGN; Adhesion Molecule; Animals; Antigens; Behavior; Behavioral; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; Cancer Patient; Cancers; Cell Adhesion Molecules; Cell Communication; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell-to-Cell Interaction; Cells; Cellular Migration; Chemoattractants; Chemotactic Factors; Chemotaxins; Cytotoxic cell; Data; Dendritic Cells; Development; Disseminated Malignant Neoplasm; Engraftment; Equilibrium; Event; Future; Generalized Growth; Goals; Growth; Heterogeneity, Population; Image; Immune; Immune system; In Situ; Individual; Infiltration; Inflammatory; K lymphocyte; LYT3; Life; Location; Lung; Lung Neoplasms; Lymphocyte; Lymphocytic; MICMET; Maintenance; Maintenances; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mediator; Mediator of Activation; Mediator of activation protein; Memory; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Tumor; Micrometastasis; Micromets; Molecular; Monitor; Motility; Motility, Cellular; NK Cells; Natural Killer Cells; Neoplasm Metastasis; Patients; Phagocytes; Phagocytic Cell; Phase; Plant Embryos; Play; Population; Population Heterogeneity; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Pulmonary Neoplasms; Regulatory T-Lymphocyte; Respiratory System, Lung; Role; Secondary Neoplasm; Secondary Tumor; Seeds; Site; Soil; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; Therapeutic; Therapeutic Studies; Therapy Research; Thymus-Dependent Lymphocytes; Tissue Growth; Tissues; Tumor Cell; Tumor Cell Migration; Tumor of the Lung; Veiled Cells; Work; Zygotes, Plant; amebocyte; balance; balance function; base; body system, allergic/immunologic; cancer cell; cancer metastasis; cancer progression; cell adhesion protein; cell motility; circulating cancer cell; complement chemotactic factor; cytotoxic; diverse populations; fighting; heterogeneous population; imaging; immunogen; lymph cell; macrophage; malignancy; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; new growth; ontogeny; organ system, allergic/immunologic; prevent; preventing; prognostic; public health relevance; pulmonary; seed; social role; theories; thymus derived lymphocyte; tumor; tumor growth; tumor progression",Immune cell interactions during tumor establishment.," Project Narrative Preventing the emergence of new tumors due to metastasis requires better understanding of factors that allow the engaftment of circulating cancer cells in healthy tissues. Using multiphoton intravital imaging of nascent lung metastases, we will characterize the recruitment and interactions of immune cells that can facilitate tumor growth or induce rejection. This study will help identify and target the earliest cell interactions for future antimetastatic therapies.",137059,TTT,"Transplantation, Tolerance, and Tumor Immunology",,2,319550,
7789608,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA137060-02,,NCI:332000;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"MUSCHEN, MARKUS ;",9218760;,5R01CA137060,03/19/2009,01/31/2014,"0-11 years old; 21+ years old; ABL1; ABL1 gene; ALL - Acute Lymphocytic Leukemia; Abelson Murine Leukemia Viral Oncogene Homolog 1; Aberrant Chromosome; Ablation; Abnormalities, Chromosomal; Acute Lymphoid Leukemia; Adult; Anti-Oncogenes; Antibody-Producing Cells; Antioncogenes; Apoptosis; Apoptosis Pathway; Avian Myelocytomatosis Viral Oncogene Homolog; B blood cells; B cell receptor; B lymphoma; B-Cell Development; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cells; B-Lymphocytes; Birth Defects; Blood (Leukemia); Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CYTOGEN; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Lineage; Cell Signaling; Cells; Characteristics; Child; Child Youth; Children (0-21); Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Classification; Clonal Evolution; Cognitive Discrimination; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cytogenetic; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytogenetics; Cytotoxic agent; Cytotoxic drug; DNA Rearrangement; Data; Defect; Development; Discrimination; Discrimination (Psychology); Disease; Disorder; Dose-Limiting; Drug resistance; EC 2.7; Elements; Emerogenes; Employee Strikes; Exhibits; Gene Rearrangement; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Goals; Growth; Heterograft; Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Human; Human Biology; Human, Adult; Human, Child; Human, General; IRF4; IRF4 gene; Immune; Immune system; Immunoglobulin-Producing Cells; Individual; Interferon Regulatory Factor 4 Gene; Intracellular Communication and Signaling; JTK7; Kinases; LSIRF Gene; Lead; Leukemia, Lymphocytic, Acute; Leukemias, General; Lymphoblastic Leukemia, Acute; Lymphogranuloma, Malignant; Lymphoma, Non-Hodgkin's; Lymphoma, Nonhodgkins; MUM1 Gene; MYC; MYC gene; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mature B-Cell; Mature B-Lymphocyte; Mice, Transgenic; Molecular Genetic Abnormality; Multiple Myeloma Oncogene 1; Non-Hodgkin's Lymphoma; Oncogenes, Recessive; Oncogenes, myc; Oncogenes-Tumor Suppressors; Oncogenic; Pathway interactions; Patients; Pb element; Phosphotransferases; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Protocols, Treatment; RGM; Receptor Activation; Receptor Signaling; Receptors, Antigen, B-Cell; Regimen; Relapse; Reticuloendothelial System, Bone Marrow; Role; SUBGP; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Staging; Strikes; Strikes, Employee; Subgroup; Systematics; Testing; Tissue Growth; Toxic effect; Toxicities; Transgenic Mice; Transphosphorylases; Transplantation, Heterologous; Treatment Protocols; Treatment Regimen; Treatment Schedule; Tumor Suppressing Genes; Tumor Suppressor Genes; Xenograft; Xenograft procedure; Xenotransplantation; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; adult human (21+); base; biological signal transduction; body system, allergic/immunologic; c-Abl; cancer type; chemotherapy; children; cytotoxic; disease/disorder; drug resistant; experiment; experimental research; experimental study; fusion gene; heavy metal Pb; heavy metal lead; improved; in vivo; leukemia; loss of function; lymphogranulomatosis; lymphogranulomatosis (malignant); malignancy; mouse model; neoplasm/cancer; non-Hodgkin's lymphoma; non-Hodgkins disease; non-Hodgkins lymphoma; novel; oncosuppressor gene; ontogeny; organ system, allergic/immunologic; pathway; pre-B cell receptor; public health relevance; receptor expression; receptor function; reconstitute; reconstitution; research study; resistance to Drug; resistant to Drug; response; shRNA; short hairpin RNA; small hairpin RNA; social role; transcription factor; treatment strategy; youngster",Pre-B cell receptor signaling in acute lymphoblastic leukemia," 7. PROJECT NARRATIVE Pre-B cell receptor signaling in acute lymphoblastic leukemia B lymphocytes are not only the cells that produce antibodies as part of the human immune system, they are also the cell of origin in most cases of acute lymphoblastic leukemia (ALL). ALL represents by far the most frequent type of cancer in children and is also a common disease in adults. For many years, patients with ALL are treated with chemotherapy and current treatment protocols lead to cure rates of 80 percent for children and 55 percent for adult patients with ALL. Our goal is to better understand the biology of human ALL, namely as a catastrophic aberration of normal B lymphocyte development. During normal B lymphocyte development, the pre-B cell receptor represents a critical signaling unit that guides early B lymphocyte precursors on their path of maturation. If signaling from the pre-B cell receptor is compromised, as for instance in patients with innate immune defects, the B lymphocyte precursors are arrested in their development at a primitive stage -as in ALL cells. Therefore, we propose to investigate the function of the pre-B cell receptor signaling unit (1) as a potential target to disrupt aberrant cell signaling that promotes leukemic growth and (2) to restore normal pre-B cell receptor signaling in the leukemia cells.",137060,HP,Hematopoiesis Study Section,,2,332000,
7778388,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA137094-02,,NCI:393005;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"O'SHEA, CLODAGH ;",8909846;,5R01CA137094,03/01/2009,01/31/2014,"Address; Adenoviridae; Adenoviridae Infections; Adenovirus Infections; Adenoviruses; Adriablastin; Adriablastine; Adriacin; Adriamycin PFS; Adriamycin RDS; Adriblastin; Adriblastina; Adriblastine; Adrimedac; Antioncogene Protein p53; Binding; Binding (Molecular Function); CHIP assay; CI-1042; CI1042; Cancer Causing Agents; Cancer Treatment; Cancers; Carcinogens; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Tumor Antigen P53; ChIP (chromatin immunoprecipitation); Chromatin; Clinical Trials; Clinical Trials, Unspecified; Complex; DNA; DNA Damage; DNA Injury; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; DOXO-CELL; Data; Deoxyribonucleic Acid; Development; Doxolem; Doxorubin; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EC 2.7; Employee Strikes; Farmiblastina; Gene Transcription; Generalized Growth; Genes, p53; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Growth; Human; Human, General; Infection; Intracellular Communication and Signaling; Kinases; Liposomal Adriamycin; Lytic; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medication; Modification; Molecular Interaction; Mutation; Normal Cell; Nuclear; ONYX-015; ONYX-015 (E1B-Attenuated Adenovirus); ONYX015; Oncogenic; Oncogens; Oncolytic viruses; Oncoprotein p53; P53; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Protein TP53; Protein p53; Proteins; Proteomics; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Repression; Research; Role; Rubex; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Strikes; Strikes, Employee; Subcellular Process; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transphosphorylases; Tumor Cell; Tumor Protein p53; Tumor Protein p53 Gene; Up-Regulation; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus Diseases; Viruses, General; adriamycin; anticancer therapy; biological signal transduction; cDNA Expression; cancer therapy; cellular targeting; chemotherapy; chromatin immunoprecipitation; chromatin modification; clinical investigation; comparative; design; designing; drug/agent; experiment; experimental research; experimental study; gene product; genome mutation; genotoxicity; histone modification; insight; interest; irradiation; kinase inhibitor; malignancy; mutant; neoplasm/cancer; neoplastic cell; novel; ontogeny; p53 Antigen; p53 Tumor Suppressor; pathway; prevent; preventing; protein protein interaction; public health relevance; research study; response; social role; therapeutic target; tumor; viral infection; virus development; virus infection; virus protein",Defining critical p53 therapeutic targets and mechanisms," Project Narrative The p53 tumor suppressor pathway is inactivated by mutations in almost every form of human cancer, but there are no targeted drugs to treat p53 mutant tumor cells. p53 is also inactivated by adenoviral proteins, which we will exploit in these studies to pinpoint critical cellular targets that could be manipulated to potentially `re-activate' p53 in 50% of human tumors. In addition, this research will provide new mechanistic insights that will enable the development of viruses that act as p53-mutation guided missiles, and which specifically replicate within p53 mutant tumor cells to implode them from the inside out.",137094,BMCT,Basic Mechanisms  of Cancer Therapeutics Study Section,,2,393005,
7778346,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA138461-02,,NCI:313533;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","WANG, LIEWEI ;",8826104;,5R01CA138461,03/01/2009,01/31/2014,"1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; 2',2'-DFDC; 2',2'-difluoro-2'-deoxycytidine; 2',2'-difluorodeoxycytidine; 2'-deoxy-2'-difluorocytidine; 2'Deoxy-2',2'-Difluorocytidine; 2,2 difluorodexoycytidine; AKT; AKT inhibition; Active Follow-up; Affect; Akt protein; Amino Acid Sequence; Animal Model; Animal Models and Related Studies; Apoptotic; Athymic Nude Mouse; Biological Models; Body Tissues; Breast; Breast Cancer Treatment; Cancer Patient; Candidate Disease Gene; Candidate Gene; Carcinoma, Non-Small-Cell Lung; Cell Communication and Signaling; Cell Line, Tumor; Cell Signaling; Cells; Clinical; Correlation Studies; Cytidine; Cytosine Ribonucleoside; Cytosine Riboside; DNA; DNA Resequencing; DNA Sequence; Data; Deoxyribonucleic Acid; Difluorodeoxycytidine; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Enzymes; Exons; Future; Gastrointestinal Tract, Pancreas; Gene Expression; Gene Products, RNA; Gene variant; Genes; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genotype; Human; Human, General; IC50; Immunophilins; Inhibitory Concentration 50; Intermediary Metabolism; Intervening Sequences; Intracellular Communication and Signaling; Introns; Knowledge; Lytotoxicity; METBL; Malignant Pancreatic Neoplasm; Malignant neoplasm of pancreas; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic Processes; Metabolism; Mice, Athymic; Mice, Nude; Model System; Models, Biologic; NSCLC; NSCLC - Non-Small Cell Lung Cancer; Non-Small Cell Lung Cancer; Non-Small-Cell Lung Carcinoma; Nucleic Acid Regulatory Sequences; Nude Mice; Ovarian; PKB protein; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenomics; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Play; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Process; Protein Kinase B; Protein Phosphorylation; Protein Structure, Primary; Proto-Oncogene Proteins c-akt; RAC-PK protein; RNA; RNA Splicing; RNA, Non-Polyadenylated; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Resequencing; Resistance; Ribonucleic Acid; Role; SNP; SNPs; Sampling; Screening procedure; Series; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Splicing; Statistical Correlation; Testing; Tissue Sample; Tissues; Tumor Cell Line; Tumor Tissue; Variant; Variation; Variation (Genetics); allelic variant; analog; anticancer research; base; biological signal transduction; biomarker; c-akt protein; cancer research; chemotherapy; cytotoxicity; dFdC; dFdCyd; drug metabolism; drug/agent; experiment; experimental research; experimental study; follow-up; functional genomics; gemcitabine; genetic regulatory element; genome-wide; in vivo; insight; lymphoblastoid cell line; model organism; mouse model; nonsmall cell lung cancer; novel; pathway; polymorphism; protein function; protein protein interaction; protein sequence; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; related to A and C-protein; research study; resistant; response; screening; screenings; social role; tumor",Pharmacogenomics and Mechanisms of Cytidine Analogues," Narrative The cytidine analogue gemcitabine is first line chemotherapy for the treatment of pancreatic cancer. However, very little is known with regard to determinants of variation in gemcitabine response, especially single nucleotide polymorphisms (SNPs) in genes outside of the ""pathway"" described by our current knowledge of the metabolism and ""targets"" for this drug. In order to identify additional genes of importance for variation in gemcitabine response, we have used 300 Human Variation Panel lymphoblastoid cell lines as a model system, together with genome-wide approaches to identify one top candidate gene, FKBP5, for which expression was significantly associated with gemcitabine sensitivity. In this application, based on extensive preliminary data, we propose to investigate mechanisms by which FKBP5 regulates response to gemcitabine and to identify genetic variation in FKBP5 that might be used as a biomarker to help predict gemcitabine response in the treatment of pancreatic cancer.",138461,DT,Developmental Therapeutics Study Section,,2,313533,
7776870,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA138546-02,,NCI:440823;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"AGGARWAL, ANEEL K.;",1874010;,5R01CA138546,03/01/2009,01/31/2014,"5'-Exonuclease; 5'-Nucleotidephosphodiesterase; Active Sites; Affect; Affinity; Alkaline Phosphodiesterase; Alkaline Phosphodiesterase I; Binding; Binding (Molecular Function); Biochemical; Biochemical Genetics; Cancer Cause; Cancer Etiology; Cancer Induction; Cancer cell line; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Cycle; Cell Division Cycle; Cell Function; Cell Process; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Complex; DNA; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Injury; DNA Polymerase III; DNA Polymerase delta; DNA Polymerases; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA lesion; DNA-Dependent DNA Polymerase III; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; EC 2.7.7.7; Eukaryota; Eukaryote; Event; Exonuclease; Family; Fluorescence Anisotropy; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Genetics-Mutagenesis; Genome Stability; Grant; Holoenzymes; Human; Human, General; Hydroxycarbamid; Hydroxycarbamide; Impairment; Kinetic; Kinetics; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mice; Minor Groove; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutation; Nucleotides; Oligonucleate 5'-Nucleotidohydrolase; Orthophosphoric Diester Phosphohydrolase; Pathway interactions; Phosphodiesterase I; Play; Pol III; Polymerase; Reaction; Role; S cerevisiae; Saccharomyces cerevisiae; Sites, Active; Stability, Genomic; Structure; Subcellular Process; Testing; Urea, hydroxy-; Yeast, Baker's; Yeast, Brewer's; Yeasts; base; carcinogenesis; conformational conversion; conformational transition; eukaryotida; genome mutation; hydroxyurea; insight; pathway; polymerization; public health relevance; social role; synthetic DNA; synthetic construct",Structural bases of high fidelity of DNA polymerase  delta," The aim of this grant is to uncover the mechanisms underlying the high fidelity of DNA polymerase ¨ (Pol¨), which is crucial for maintaining genomic stability and the suppression of carcinogenesis. Mutations that lower the fidelity of Pol¨ cause cancers in mice and humans.",138546,MSFE,Macromolecular Structure and Function E Study Section,,2,440823,
7799126,R01,CA,5,,02/01/2010,01/31/2011,PA-07-256,5R01CA138623-02,,NCI:305898;,2010,NATIONAL CANCER INSTITUTE,,LOUISVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"BODDULURI, HARIBABU ;",6078594;,5R01CA138623,04/01/2009,01/31/2014,"6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))-; APC; APC gene; Acute; Adenomatosis Polyposis Coli Gene; Adoptive Transfer; Affinity; Airway Hyper-responsiveness; Anaphylactic Reaction; Anaphylaxis; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Arthritis; Asthma; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoregulation; Azoxymethane; BLT1; BLTR; Biological Models; Bone Marrow; Bowel Cancer; Bronchial Asthma; CMKRL1; Cancer Cause; Cancer Etiology; Cancer Model; CancerModel; Cancers; Cells; Cessation of life; Chimera; Chimera organism; Chronic; Colon Cancer; Colon Carcinoma; Colon Neoplasms; Colonic Carcinoma; Colonic Mass; Colonic Neoplasms; Colonic Tumor; Colorectal Cancer; Consumption; DP2; DP2.5; DP3; Death; Defect; Development; Diazene, dimethyl-, 1-oxide; Diet; Disease; Disorder; Dysfunction; Environment; Environmental Factor; Environmental Risk Factor; Event; Exposure to; FPC; Functional disorder; GPR16; Gene variant; Genes; Genes, Adenomatous Polyposis Coli; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Variation; Genetic defect; Gut Inflammation; Homeostasis; Host Defense; Host Factor; Host Factor Protein; Human; Human, General; INFLM; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune Function, Cellular; Immune Surveillance; Immune System Diseases; Immune System Disorder; Immune response; Immune system; Immunologic Diseases; Immunologic Surveillance; Immunological Diseases; Immunological Surveillance; Infection; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Integration Host Factors; Intestinal; Intestinal Cancer; Intestinal Inflammation; Intestinal Neoplasia; Intestinal Neoplasms; Intestinal Tumor; Intestines; Intestines Cancer; Intestines Neoplasms; LTB4; LTB4 Receptors; LTB4R; LTB4R gene; LTB4R1; LTBR1; Laboratories; Leukotriene B-4; Leukotriene B4; Leukotriene B4 Receptors; Leukotrienes; Link; Malignant; Malignant - descriptor; Malignant Intestinal Neoplasm; Malignant Intestinal Tumor; Malignant Neoplasm of the Intestine; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Intestine; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Mice; Mice, Transgenic; Miscellaneous Antibiotic; Model System; Modeling; Models, Biologic; Molecular Carcinogenesis; Murine; Mus; Mutation; Organ System; P2RY7; P2Y7; Pathogenesis; Pathway interactions; Phenotype; Physiological Homeostasis; Physiopathology; Play; Process; Promoters, Tumor; Proteins; RNA, Messenger; Receptor Protein; Reticuloendothelial System, Bone Marrow; Role; Shapes; Shock, Anaphylactic; Sodium Dextran Sulfate; Surveillances, Immunologic; Surveillances, Immunological; Testing; Toll-Like Receptor Pathway; Transgenic Mice; Tumor Promoters; Tumor of the Colon; Tumor of the Intestines; United States; Variation (Genetics); airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; allelic variant; arthritic; atheromatosis; atherosclerotic vascular disease; base; body system; body system, allergic/immunologic; bowel; cell type; disease/disorder; environmental agent; environmental risk; gene product; genome mutation; gut microbiota; gut microflora; host response; immune function; immunoresponse; intestine growth; mRNA; malignancy; microbial; microbial colonization; microbial interaction; microbicidal; microbicide; microorganism interaction; mouse model; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathophysiology; pathway; protein expression; public health relevance; receptor; social role; tumor",Role of leukotriene B4 receptors in the interplay of inflammation and infection," Project Narrative Leukotrienes are involved in the pathophysiology of many acute and chronic inflammatory diseases such as systemic anaphylaxis, asthma, atherosclerosis and arthritis. The novel finding that leukotriene B4-leukotriene B4 receptor1 axis may have a protective function in the development of colon cancer offers a unique opportunity to understand the role of these mediators in tumor development. Understanding the precise function of distinct leukotriene B4 receptors in mice and defining the role of these receptors in host defense and shaping the gut microflora will provide novel approaches to the treatment of colon cancer.",138623,GMPB,Gastrointestinal Mucosal Pathobiology Study Section,,2,305898,
7778320,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA138727-02,,NCI:307100;,2010,NATIONAL CANCER INSTITUTE,,WINSTON-SALEM,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"METHENY-BARLOW, LINDA J;",6135249;,5R01CA138727,03/01/2009,01/31/2014,"ANG1; ANGPT1; Address; Adventitial Cell; Affect; Agents, Stabilizing; Angiopoietin-1; Anti-VEGF; Anti-VEGF Humanized Monoclonal Antibody; Anti-VEGF RhuMAb; Attention; Bevacizumab (rhuMAb VEGF); Blood Vessels; Brain; Brain Edema; Brain Neoplasia; Brain Neoplasms; Brain Swelling; Brain Tumors; Breast; Breast Cancer Model; Breast Neoplasms; Breast Tumors; Cancer Control; Cancer Control Science; Cancer of Breast; Cardiovascular Diseases; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Communicating Junction; Communication; Connexin 43; Connexin43; Connexins; Cx43; Data; Defect; Dropsy; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Edema; Encephalon; Encephalons; Endothelial Cells; Endothelium; Ensure; Event; Exhibits; Exposure to; Extravasation; Gap Junction Proteins; Gap Junctions; Generalized Growth; Growth; Human; Human, General; Hydrops; In Vitro; Incidence; Intercellular Fluid; Interstitial Fluids; Intracranial Edema; Lead; Leakage; Leiomyocyte; Low-resistance Junction; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Measures; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Metastatic to; Mice; MoAb VEGF; Modeling; Monoclonal Antibody Anti-VEGF; Murine; Mus; Myocytes, Smooth Muscle; Neoplasm Metastasis; Nervous System, Brain; Nexus; Nexus Junction; Normal Tissue; Normal tissue morphology; Occluding Junctions; Pathway interactions; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Play; Pressure; Pressure- physical agent; Proliferating; Protein Phosphorylation; Proteins; Recombinant Humanized Anti-VEGF Monoclonal Antibody; Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor; Regulation; Reporting; RhuMAb VEGF; Role; Rouget Cells; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Site; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spillage; Stabilizing Agents; Testing; Therapeutic; Tight Junctions; Tissue Growth; Tumor Angiogenesis; Tumor Cell; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Vascular Permeabilities; Vasomotor; Work; Zonula Occludens; angiogenesis; base; bevacizumab; blood vessel restoration; cancer metastasis; cardiovascular disorder; cell growth; cell type; drug/agent; feeding; functional loss; gene product; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; malignant breast neoplasm; mammary cancer model; mammary tumor; mammary tumor model; mutant; neoplastic cell; novel; ontogeny; overexpression; pathway; precursor cell; pressure; prevent; preventing; public health relevance; response; rhuMabVEGF; social role; success; tumor; tumor growth; tumors in the brain; vascular; wet brain",Regulation of Vascular Stabilization by Connexin 43,"  The leaky, unstable blood vessels found in tumors facilitate tumor growth, impair drug delivery, and facilitate metastasis. Success of the proposed studies will identify vascular Connexin 43 as a novel target to normalize the tumor vasculature and thereby inhibit angiogenesis, decrease metastasis, and enhance drug delivery, ultimately leading to better cancer control.",138727,TME,Tumor Microenvironment Study Section,,2,307100,
7771701,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA138738-02,,NCI:393420;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"BRENTJENS, RENIER JOSEPH;",8646683;,5R01CA138738,03/01/2009,01/31/2014,"Address; Adoptive Cellular Immunotherapy; Adoptive Immunotherapy; Adverse effects; Antibodies; Antibody Therapy; Antigen Presentation; Antigen Receptors; Antigen Targeting; Antigenic Determinants; Autologous; Award; B Cell Antigen CD19; B blood cells; B cell tumor; B-Cell CLL; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Cell Lymphocytic Neoplasm; B-Cell Neoplasm; B-Cells; B-Lymphocyte Antigen CD19; B-Lymphocyte Surface Antigen B4; B-Lymphocytes; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; B-lineage tumor; Binding; Binding (Molecular Function); Binding Determinants; Biology; Blood (Leukemia); Bp35; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C2B8 Monoclonal Antibody; CD19; CD19 Antigens; CD19 gene; CD19 molecule; CD20; CD28; CD28 gene; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; CSIF; CSIF-10; Cancer Patient; Cancers; Cell Communication and Signaling; Cell Function; Cell Line, Tumor; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytolysis; Cytotoxic cell; Data; Detection; Differentiation Antigen CD19; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Edodekin Alfa; Elements; Epitopes; Ethics Committees, Research; FLR; Failure (biologic function); Funding; Future; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Goals; Hematopoietic Cell Tumor; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Heterograft; Human; Human, General; IL-10; IL-12; IL10; IL10A; IL12; IRBs; Immune; Immune Escape, Tumor; Immune system; Immunosuppressants; Immunosuppressive Agents; Immunotherapy, Adoptive; In Vitro; Institutional Review Boards; Interleukin 10 Precursor; Interleukin-10; Interleukin-12; Intervention, Genetic; Intracellular Communication and Signaling; K lymphocyte; Killings; Knock-in; Knock-in Mouse; Knock-out; Knockout; Laboratories; Length; Leu 12; Leu-16; Leukemia, B-Cell; Leukemias, General; Ligands; Lymphoblastic Leukemia, Chronic; Lymphocytes, Tumor-Infiltrating; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; Lysis; MHC Receptor; MS4A1; MS4A1 gene; MS4A2; Major Histocompatibility Complex Receptor; Malignant Cell; Malignant Hematopoietic Neoplasm; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Molecular Biology, Gene Therapy; Molecular Interaction; Murine; Mus; NK Cells; NKSF; Natural Killer Cell Stimulatory Factor; Natural Killer Cells; OKT3 antigen; Patients; Proteins; Protocol; Protocols documentation; Publishing; Reagent; Receptor Gene; Receptor Protein; Receptors, Antigen; Receptors, Antigen, T-Cell; Recruitment Activity; Refractory; Regulatory T-Lymphocyte; Research Ethics Committees; Resistance; Rituximab (C2B8 Antibody); Role; SCID Beige; SCID Beige Mouse; Safety; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solid Neoplasm; Solid Tumor; Subcellular Process; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T3 Antigens; T3 Complex; T3 molecule; T44; Technology; Testing; Therapeutic; Therapy, DNA; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Transgenic Organisms; Transplantation, Heterologous; Treatment Side Effects; Tumor Antigens; Tumor Cell; Tumor Cell Line; Tumor Escape; Tumor-Associated Antigen; Tumor-Derived; Tumor-Infiltrating Lymphocytes; Xenograft; Xenograft procedure; Xenotransplantation; adoptive cell immunotherapy; base; biological signal transduction; blood cancer; body system, allergic/immunologic; cancer cell; chemotherapy; chronic lymphoid leukemia; clinical investigation; clinical relevance; clinically relevant; cytokine; design; designing; disease/disorder; failure; gene product; gene therapy; genetic manipulation; genetic therapy; immunogenic; immunosuppressive; improved functioning; in vivo; leukemia; malignancy; neoplasm/cancer; neoplastic cell; novel; organ system, allergic/immunologic; pre-clinical; preclinical; public health relevance; receptor; recruit; resistant; rituximab; safety study; side effect; social role; suicide gene; suicide vector; therapy adverse effect; thymus derived lymphocyte; trafficking; transgenic; treatment adverse effect; tumor; tumor eradication; tumor-specific antigen; vector",Adoptive Immunotherapy of Cancer with IL-12 Secreting Tumor-Targeted T cells," By using gene therapy approaches, a cancer patient's own immune cells can be modified in such a way that they can subsequently recognize and kill cancer cells. We are already using this technology to test this treatment approach in patients with blood cancers (leukemias). The goal of this project is to improve the function of these cells to make them better suited to treat patients with persistent cancer after chemotherapy.",138738,CII,Cancer Immunopathology and Immunotherapy Study Section,,2,393420,
7788784,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA139032-02,,NCI:332000;,2010,NATIONAL CANCER INSTITUTE,,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"MUSCHEN, MARKUS ;",9218760;,5R01CA139032,03/18/2009,01/31/2014,"0-11 years old; 2,4-Dioxo-5-fluoropyrimidine; 21+ years old; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine; 5-FC; 5-FU; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-Fluorocytosine; 5-Fluorouracil; 5-Fluracil; 5FU; ABL1; ABL1 gene; AICDA; AICDA protein; ALL - Acute Lymphocytic Leukemia; Abelson Murine Leukemia Viral Oncogene Homolog 1; Acute Lymphoid Leukemia; Address; Adult; Alcobon; Ancobon; Ancotil; B blood cells; B cell-specific activator protein; B-Cell Lineage Specific Activator Protein; B-Cell Specific Transcription Factor; B-Cells; B-Lymphocytes; BSAP; BSAP protein; Blast Crisis; Blast Phase; Blast Phase CML; Blast Phase Chronic Granulocytic Leukemia; Blast Phase Chronic Myelocytic Leukemia; Blast Phase Chronic Myelogenous Leukemia; Blast Phase Chronic Myeloid Leukemia; Blastic Phase CML; Blastic Phase Chronic Granulocytic Leukemia; Blastic Phase Chronic Myelocytic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myeloid Leukemia; Blood (Leukemia); Blood Precursor Cell; Blood monocyte; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CASPR; CDA2 protein; CDR; CNTNAP; CNTNAP1; CNTNAP1 gene; Cancers; Cell Lineage; Cells; Child; Child Youth; Children (0-21); Chromosomal, Gene, or Protein Abnormality; Chronic Myeloid Leukemia; Chronic Phase; Chronic Phase CML; Chronic Phase Chronic Granulocytic Leukemia; Chronic Phase Chronic Myelocytic Leukemia; Class Switching; Clinical Evaluation; Clinical Testing; Clonal Evolution; Comparative Genome Hybridization; Congenic Mice; Contactin Associated Protein 1 Gene; Cytidine, 2'-deoxy-; Cytogenetic or Molecular Genetic Abnormality; Cytosine Deoxyribonucleoside; Cytosine Deoxyriboside; DNA Recombination; DNA recombination (naturally occurring); Data; Deoxycytidine; Development; Disease; Disorder; Drug Precursors; Drug resistance; EBB-1 protein; EC 2.7; Engineering; Engineerings; Enzymes; FISH Technic; FISH Technique; FISH analysis; Flucytosine; Fluorescent in Situ Hybridization; Fluoro Uracil; Fluorouracil; Fluoruracil; Fluouracil; Forecast of outcome; Genes; Genes, Ig; Genes, Immunoglobulin; Genetic; Genetic Abnormality; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Genotype; Goals; Granulocytic Leukemia, Chronic, Stable-Phase; Hematopoietic stem cells; Hot Spot; Hot Spots (Area of Increased Mortality); Human, Adult; Human, Child; Ig Somatic Hypermutation; Imatinib; Immunoglobulin Class Switching; Immunoglobulin Genes; Immunoglobulin Somatic Hypermutation; In Situ Hybridization, Fluorescence; In Vitro; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Isotype Switching; JTK7; Kinases; Label; Lead; Leukemia, Granulocytic, Chronic; Leukemia, Granulocytic, Chronic-Phase; Leukemia, Lymphocytic, Acute; Leukemia, Myelogenous, Chronic-Phase; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Stable-Phase; Leukemias, General; Life; Lymphoblastic Leukemia, Acute; Lymphoid; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Maps; Marrow monocyte; Mediating; Mice; Mice, Congenic; Mice, Transgenic; Molecular Abnormality; Murine; Mus; Mutation; Myelocytic Leukemia, Chronic; Myelogenous Leukemia, Chronic; Myelogenous Leukemia, Chronic, Chronic-Phase; Myeloid Cells; Myeloid Leukemia, Chronic; Myeloid Leukemia, Chronic, Chronic-Phase; Myeloid Leukemia, Chronic, Stable-Phase; N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine; NF-HB protein; NRXN4; Neurexin 4 Gene; Neurexin IV Gene; Oncogenic; Outcome; P190; PAX5; PAX5 gene; Paired Box 5; Paired Box Homeotic Gene 5; Paired Box Protein Pax-5; Patients; Pax-5 protein; Pb element; Ph 1 Chromosome; Ph1 Chromosome; Philadelphia Chromosome; Phosphotransferases; Play; Population; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Pro-Drugs; Prodrugs; Progenitor Cells, Hematopoietic; Prognosis; Progressive Disease; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Recombination; Recombination, Genetic; Relapse; Reporter; Resistance; Resistance development; Resistant development; Role; SUBGP; Series; Somatic Hypermutation, Immunoglobulin; Somatic Mutation; Staging; Subgroup; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; System; System, LOINC Axis 4; Testing; Time; Transgenic Mice; Transphosphorylases; Work; Xeloda; activation-induced cytidine deaminase; activation-induced deaminase; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; adult human (21+); base; c-Abl; capecitabine; children; clinical test; comparative genomic hybridization; cytotoxic; developing resistance; disease/disorder; drug resistant; early B cell-specific binding protein-1; experiment; experimental research; experimental study; fluorocytosine; genome mutation; heavy metal Pb; heavy metal lead; in vivo; kinase inhibitor; leukemia; macrophage; malignancy; monocyte; mouse model; neoplasm/cancer; novel; outcome forecast; overexpression; paired box 5 protein (B-cell lineage specific activator); pre-clinical; preclinical; prevent; preventing; public health relevance; research clinical testing; research study; resistance to Drug; resistant; resistant to Drug; social role; somatic hypermutation; success; transcription factor; treatment response; treatment strategy; youngster",AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia," 7. NARRATIVE The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 kinase, which drives two types of leukemia: Acute lymphoblastic leukemia (Ph+ ALL) is derived from a transformed B lymphocyte and chronic myeloid leukemia (CML) originates from myeloid cells that would otherwise develop into macrophages or monocytes. While Ph+ ALL represents a rapidly progressive disease already at the outset, the course of CML is typically stable over many years and only shows rapid progression in the terminal stage, the so-called ""blast crisis"". The reasons leading to progression from chronic phase into blast crisis are largely unknown.  The treatment of both Ph+ ALL and CML has been revolutionized by the discovery of the BCR-ABL1 kinase-inhibitor Imatinib. However, even though both leukemia types carry the same genetic abnormality, the outcome of Imatinib-treatment is strikingly different: whereas Imatinib is very effective in the treatment of chronic phase CML, treatment success is only transient for patients with Ph+ ALL or blast crisis CML. In these patients, the leukemia recurs after 4 months on average and is typically drug-resistant owing to the acquisition of additional mutations. Therefore, the understanding of the underlying mutation mechanism and its potential inhibition appears to be critical for further improvement of treatment strategies of Ph+ ALL and CML.  Recent work by our group demonstrated that the oncogenic BCR-ABL1 kinase in Ph+ ALL and blast crisis, but not chronic phase CML, induces expression of a mutator enzyme, termed AID (Activation-induced Cytidine Deaminase). The mutations that confer drug-resistance in Ph+ ALL and blast crisis CML can indeed be explained by activity of the AID enzyme. Additional experiments showed that engineered expression of AID in AID-negative chronic phase CML cells introduces the same mutations that cause drug-resistance in patients with AID-positive Ph+ ALL and CML blast crisis. Based on these observations, we propose four series of experiments to address the following questions:  (1) Is the AID enzyme required for drug-resistance in AID-positive Ph+ ALL? To test this hypothesis, we will  investigate whether BCR-ABL1-induced leukemia cells from mice carrying a deletion of the AID-gene  fail to develop drug-resistance.  (2) Does the AID enzyme play a critical role in the progression of chronic phase CML into blast crisis?  Chronic phase CML can be treated very successfully for many years, whereas blast crisis represents a  final and often fatal stage of the disease.  (3) Which are the factors that induce aberrant expression of the AID enzyme in Ph+ ALL and blast crisis  CML? The identification of such factors will likely help to understand how expression of this deleterious  mutator enzyme can be prevented.  (4) Is it possible to target AID-expressing cells by taking advantage of the enzymatic activity of AID? For  this approach, we propose to use a precursor-drug that has no effect as such but will become toxic  upon AID-mediated conversion. Given that AID-expressing cells are more likely to be drug-resistant  than others, we propose a treatment approach that is focused on the AID-expressing leukemia cells.",139032,HP,Hematopoiesis Study Section,,2,332000,
7786285,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA139395-02,,NCI:390873;,2010,NATIONAL CANCER INSTITUTE,,NEW HAVEN,UNITED STATES,PHARMACOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"WU, DIANQING ;",1887065;,5R01CA139395,04/01/2009,01/31/2014,"(1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APC - Adenomatous Polyposis Coli; ATP[{..}]protein-tyrosine O-phosphotransferase; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Adenosine; B blood cells; B-Cells; B-Lymphocytes; BZS; Binding; Binding (Molecular Function); Bio-Informatics; Biochemical; Bioinformatics; Biological; Bone Development; Breast Neoplasms; Breast Tumors; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C elegans; C.elegans; Caenorhabditis elegans; Cats; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Process; Cell Signaling; Cell Surface Receptors; Cell membrane; Cell physiology; Cell-to-Cell Interaction; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chiro-Inositol; Collaborations; Complex; Cyclic GMP; Cytoplasmic Membrane; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Defect; Developmental Process; Disease; Disorder; Domestic Cats; Drosophila; Drosophila genus; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epistasis; Epistasis, Genetic; Epistatic Deviation; Event; Exhibits; Expeditions; Extracellular Matrix, Integrins; FZD6 Protein; FZD6 protein, human; Familial Adenomatous Polyposis Syndrome; Family; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Figs; Figs - dietary; Fishes; Frizzled 6; Fruit Fly, Drosophila; Funding; G Protein-Coupled Receptor Genes; G-Proteins; GFAC; GPCR; GPR; GTP; GTP Binding; GTP Phosphohydrolases; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPases; Gene Transcription; GeneHomolog; Generations; Genes; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Epistasis; Genetic Transcription; Genetic defect; Genome; Glycogen Synthase Kinases; Glycoproteins; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanosinetriphosphatases; HEK3; Hand; HeLa; Hela Cells; Hereditary Adenomatous Polyposis Coli; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Hfz6 protein, human; Homolog; Homologous Gene; Homologue; Human; Human, General; Inositide Phospholipids; Inositol; Inositol Phosphoglycerides; Inositol Phospholipids; Integral Membrane Protein; Integrins; Interaction Deviation; Intermediary Metabolism; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Ion Channel; Ionic Channels; Isoforms; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; L-Proline; L-Serine; L-Threonine; LDL; LDL-Receptor Related Proteins; LEF Transcription Factor; Laboratories; Lead; Libraries; Ligands; Link; Lipoprotein LDL Receptors; Lipoproteins, LDL; Low Density Lipoprotein Receptor; Low Density Lipoprotein-Related Proteins; Low-Density Lipoproteins; Lymphoid; Lymphoid Enhancer Factor; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; METBL; MHAM; MMAC1; Macropain; Macroxyproteinase; Mammalia; Mammalian Cell; Mammals; Mammals, Cats; Mammals, General; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Channels; Membrane Protein Traffic; Membrane Traffic; Mesoinositol; Metabolic Processes; Metabolic syndrome; Metabolism; Mice; Minor; Molecular; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Multicatalytic Proteinase; Murine; Mus; Mutation; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nucleus; Oncogenesis; Organism; PIP2; PRKM8; PTDINS5P; PTEN; PTEN gene; PTEN1; PTK; Pathway interactions; Pb element; Phenotype; Phosphatase and Tensin Homolog; Phosphatases; Phosphatides; Phosphatidyl Inositol; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphohydrolases; Phosphoinositides; Phospholipids; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Plasma Membrane; Play; Point Mutation; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Position; Positioning Attribute; Process; Production; Proline; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Binding; Protein Isoforms; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proteosome; PtIns 4,5-P2; PtdIns; PtdIns(4,5)P2; PtdIns-5-P; PtdInsP2; RNA Expression; RNA Splicing; RNA, Small Interfering; Receptor Protein; Receptors, Cell Surface; Receptors, LDL; Recruitment Activity; Regulation; Reporter Genes; Reporting; Research Proposals; Role; SAPK1; Scaffolding Protein; Screening procedure; Sequence Homology; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Small G-Proteins; Small GTPases; Small Interfering RNA; Solid; Source; Splicing; Stimulus; Stream; Structural Biologist; Structure; Subcellular Process; System; System, LOINC Axis 4; T Cell Factor; TCF Transcription Factor; TM Domain; Threonine; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transducers; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; United States National Institutes of Health; Up-Regulation; Variant; Variation; Wnt proteins; Work; Xenopus; base; beta-Lipoproteins; biological signal transduction; bone mass; cGMP; cell type; cultured cell line; d-Numb; disease/disorder; enhancing factor; experiment; experimental research; experimental study; extracellular; familial adenomatous polyposis; familial polyposis; frizzled homolog 6 (Drosophila), human; fruit fly; gene product; gene x gene interaction; genetic epistases; genome mutation; guanosine 3'5' monophosphate; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; high risk; homology (molecular); human FZD6 protein; hydroxyaryl protein kinase; living system; mammary tumor; member; membrane structure; migration; multicatalytic endopeptidase complex; novel; numb protein; osteogenic; pathway; phosphatidylinositol 5-phosphate; phosphatidylinositol phosphate, PtdIns(4,5)P2; plasmalemma; protein function; public health relevance; receptor; recruit; research study; response; screening; screenings; siRNA; social role; tumor; tumorigenesis; tyrosyl protein kinase; wortmannin",Wnt signaling," Cell-cell communication is essential for normal functions of multi-cellular organisms including human. Problems in this process would lead to various pathological conditions including tumorigenesis. This research proposal is to understand how the Wnt protein, one of the key molecules in cell-cell communication, regulate cellular functions and how the defects in this mechanism would cause diseases.",139395,ICI,Intercellular Interactions,,2,390873,
7762168,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA139454-02,,NCI:323289;,2010,NATIONAL CANCER INSTITUTE,,STONY BROOK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"RIGAS, BASIL ;",1947960;,5R01CA139454,03/01/2009,01/31/2014,"(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; 2-(Difluoromethyl)-DL-ornithine; Accounting; Acetylation; Active Oxygen; Adenoma of the Colon; Adenomatous Polyp of the Colon; Adverse effects; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Athymic Nude Mouse; Blood Plasma; Cancer Cell Growth; Cancer Control; Cancer Control Science; Cancer Induction; Cancers; Cells; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Clinical Trials; Clinical Trials, Unspecified; Colon Cancer; Colon Carcinoma; Colonic Adenoma; Colonic Adenomatous Polyp; Colonic Carcinoma; Colorectal Cancer; DFMO; DL-alpha-Difluoromethylornithine; Data; Death; Development; Drug toxicity; Drugs; Eflornithine (DFMO ORNIDYL); Enzymes; Evaluation; Exanthem; Exanthema; Generalized Growth; Generations; Growth; Hepatic; Heterograft; Human; Human, General; In Vitro; Individual; Intestinal; Intestines; Itching; Kidney; L-Ornithine carboxy-lyase; Life; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Mice; Mice, Athymic; Mice, Nude; Murine; Mus; Nude Mice; ODC; Ornithine Carboxy-lyase; Ornithine Decarboxylase; Oxygen Radicals; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma; Polyamine Compound; Polyamines; Prevention; Pro-Oxidants; Property; Property, LOINC Axis 2; Pruritic Disorder; Pruritis; Pruritus; Publishing; Rash; Reactive Oxygen Species; Recurrence; Recurrent; Reticuloendothelial System, Serum, Plasma; Safety; Seminal; Serum, Plasma; Signal Pathway; Skin Rash; Staging; Sulindac; Testing; Time; Tissue Growth; Transplantation, Heterologous; Treatment Side Effects; Urinary System, Kidney; Western World; Work; Xenograft; Xenograft procedure; Xenotransplantation; adenoma; anticarcinogenic; base; bowel; cancer cell; cancer prevention; carcinogenesis; chemotherapy; cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; clinical investigation; difluoromethylornithine; dosage; drug/agent; gastrointestinal; malignancy; model organism; neoplasm/cancer; novel; ontogeny; preclinical evaluation; prevent; preventing; public health relevance; renal; side effect; therapy adverse effect; treatment adverse effect",Colon Cancer Prevention with Phospho-Sulindac," The development of effective and safe chemopreventive agents represents a high priority. We have synthesized a new derivative of sulindac, phospho-sulindac, which is more effective and safer than conventional sulindac. We propose to evaluate phospho-sulindac in combination with difluoromethylornithine (DFMO) for the prevention of colon cancer. This is based on the recently demonstrated ability of conventional sulindac plus DFMO to reduce the recurrence of all human colon adenomas by 69% and of advanced adenomas by 92%. Conventional sulindac, however, has significant side effects: gastrointestinal (20%); CNS (10%), skin rash and pruritus (5%), and elevations of hepatic enzymes. We anticipate that phospho-sulindac will be safer and more effective than sulindac. The proposed work will contribute to its preclinical evaluation, which is required for phospho-sulindac to be tested in humans.",139454,ZRG1,Special Emphasis Panel,,2,323289,
7777276,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA139520-02,,NCI:319550;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"YEH, EDWARD T.H.;",1869624;,5R01CA139520,03/01/2009,01/31/2014,"APF-1; ATP-Dependent Proteolysis Factor 1; Anemia; Basic Mechanisms of SUMOylation; Binding; Binding (Molecular Function); Biological; Blood Vessels; Cell Nucleus; Cells; Complex; Cytoplasm; Development; ECSF; Embryo; Embryonic; Environment; Enzymes; Epoetin; Erythropoiesis; Erythropoietin; Esteroproteases; Exposure to; Family; Gene Transcription; Genes; Genetic Transcription; Genital System, Male, Prostate; Gestation; Glycolysis; HMG-20; High Mobility Protein 20; Hour; Human Prostate; Human Prostate Gland; Hydrolase; Hydroxyl; Hydroxyl Radical; Hydroxylation; Hypoxia; Hypoxia Inducible Factor; Hypoxic; L-Proline; Lead; Ligase; Mammals, Mice; Mediating; Mice; Modification; Molecular Interaction; Murine; Mus; Nuclear; Nucleus; O element; O2 element; Oxygen; Oxygen Deficiency; Pb element; Peptidases; Peptide Hydrolases; Phase; Play; Pregnancy; Process; Production; Proline; Prostate; Prostate Gland; Prostatic Gland; Proteases; Proteinases; Proteins; Proteolytic Enzymes; RNA Expression; Regulation; Role; Sequence Homology; Substrate Specificity; Sumoylation Pathway; Synthetases; Testing; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Tumor Angiogenesis; Ubiquitilation; Ubiquitin; Ubiquitin Like Proteins; Ubiquitination; Ubiquitinoylation; VEGFs; VHL gene product; VHL protein; Vascular Endothelial Growth Factors; Vegf; angiogenesis; base; egg; elongin B; erythrocyte colony stimulating factor; experiment; experimental research; experimental study; fetal; gene product; heavy metal Pb; heavy metal lead; hematopoietin; homology (molecular); insight; novel; protein function; public health relevance; research study; response; social role; stem; tumor; ubiquination; ubiquitin conjugation; ubiquitin ligase; vascular; von Hippel Lindau disease gene product; von Hippel Lindau disease protein; von Hippel Lindau gene product; von Hippel Lindau protein",De-SUMOylation and the Hypoxic Response," We discovered a protein called SENP1 that can remove SUMO (Small Ubiquitin-like modifier) from SUMO- modified proteins. Deletion of SENP1 in mouse causes the embryo to die early due to severe anemia because SENP1 is required to maintain the stability of hypoxia-inducible factor 1¨ (HIF1¨) in the hypoxic environment. We will study how SENP1 is regulated by hypoxia, how HIF1¨ is modified by SUMO, and how SENP1 can regulate the development of normal and abnormal blood vessels.",139520,VCMB,Vascular Cell and Molecular Biology Study Section,,2,319550,
7808899,R01,CA,5,,03/01/2010,02/28/2011,PA-07-070,5R01CA140173-02,,NCI:427079;,2010,NATIONAL CANCER INSTITUTE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"LAWRENCE, DAVID S.;",1865876;,5R01CA140173,05/01/2009,02/28/2014,"Address; Androgenic Agents; Androgenic Compounds; Androgens; Behavior; Biochemical; Biochemical Process; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Detection; Diagnosis; Diagnostic; Disease; Disorder; Engineering; Engineerings; Environment; Forecast of outcome; Instrumentation, Other; Interdisciplinary Research; Interdisciplinary Study; Intracellular Communication and Signaling; Life; Link; Metastatic Prostate Cancer; Methods; Molecular; Multidisciplinary Collaboration; Multidisciplinary Research; Nature; Pathway interactions; Phenotype; Plastics; Prognosis; Programs (PT); Programs [Publication Type]; Prostate Carcinoma Metastatic; Reporter; Research; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Study, Interdisciplinary; Therapeutic Androgen; Therapeutic Intervention; Uncertainty; analog; biological signal transduction; cell type; cultured cell line; disease/disorder; doubt; enzyme activity; inhibitor; inhibitor/antagonist; instrument; instrumentation; intervention therapy; multidisciplinary; new technology; outcome forecast; pathway; prognostic; programs; public health relevance; response; tool",Signaling Network Dynamics in Metastatic Prostate Cancer," Project Narrative Current methods for the detection, diagnosis, and prognosis of metastatic prostate cancer (CaP) are subject to misinterpretation and do not directly address key biochemical processes responsible for the transformed phenotype. The proposed multidisciplinary collaborative research program will develop new technology to assess the dynamics of the signaling network linked to CaP.",140173,ZRG1,Special Emphasis Panel,,2,427079,
7792399,R01,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R01CA141341-10,,NCI:255099;,2010,NATIONAL CANCER INSTITUTE,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ZHENG, YI ;",1902268;,5R01CA141341,01/01/2000,01/31/2014,"Actins; Adhesion Molecule; Adhesions; Affinity; Ancient Neurilemmoma; Ancient Schwannoma; Animals; BCR-ABL; BCR-ABL Oncoprotein; BCR-ABL Protein Tyrosine Kinase; BCR/ABL; Bears; Biochemical; Biological; Bizzozero's corpuscle/cell; Blood; Blood (Leukemia); Blood Platelets; Blood Precursor Cell; Blood erythrocyte; Blood normocyte; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bone Marrow Stem Cell; Cancer Treatment; Cancers; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chemistry, Pharmaceutical; Complex; Cristobalite; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Deetjeen's body; Degenerated Neurilemmoma; Degenerated Schwannoma; Distal; Drug Kinetics; Embryo; Embryonic; Erythrocytes; Erythrocytic; Event; Family; Fibroblasts; Funding; Fusion Proteins, bcr-abl; Future; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GFAC; GTP GDP exchange factor; GTP Phosphohydrolases; GTPases; Gene Targeting; Generations; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Hayem's elementary corpuscle; Hematopoietic; Hematopoietic Stem Cell Mobilization; Hematopoietic stem cells; Heterograft; Human; Human, General; Imatinib; In Vitro; Intracellular Communication and Signaling; Isoforms; Kinetic; Kinetics; Lead; Leukemia, Granulocytic; Leukemias, General; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Marrow platelet; Mediating; Medicinal Chemistry; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Micro-tubule; Microtubules; Modeling; Molecular; Murine; Mus; Myelocytic Leukemia; Myelogenous Leukemia; Myeloid Leukemia; Neoplasm Metastasis; Neurilemmoma; Neurilemoma; Neurinoma; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Organ; Pathologic; Pb element; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Pharmacokinetics; Phenotype; Physiologic; Physiological; Platelets; Progenitor Cells, Hematopoietic; Property; Property, LOINC Axis 2; Protein Isoforms; Publications; Reaction; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Regulatory Protein; Resolution; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Platelets; Role; Sand; Schwannoma; Scientific Publication; Screening procedure; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Silica; Silicon Dioxide; Specificity; Stem Cell Leukemia; Stem Cell Mobilization; Stream; Stress; Structure; Structure-Activity Relationship; Subcellular Process; T-Cells; T-Lymphocyte; Targetings, Gene; Therapeutic; Therapeutic Effect; Thrombocytes; Thymus-Dependent Lymphocytes; Toxic effect; Toxicities; Transducers; Translating; Translatings; Transplantation, Heterologous; Tridymite; Tumor Cell Migration; Ursidae; Ursidae Family; Validation; Work; Xenograft; Xenograft procedure; Xenotransplantation; anti-cancer therapeutic; anticancer research; anticancer therapeutic; anticancer therapy; base; bcr-abl Fusion Proteins; biological signal transduction; blood corpuscles; cancer cell; cancer metastasis; cancer research; cancer therapy; cell adhesion protein; cell behavior; chemical structure function; combinatorial; conventional therapy; cytokine; design; designing; effective therapy; exchange factor; genetic regulatory protein; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; human disease; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; kinase inhibitor; language translation; leukemia; malignancy; member; migration; mouse model; myeloid granulocytic leukemia; myelosis; neoplasm/cancer; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; pre-clinical; preclinical; progenitor; public health relevance; reconstitute; reconstitution; regulatory gene product; response; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; screening; screenings; small molecule; social role; stem; structure function relationship; therapeutic target; thrombocyte/platelet; thymus derived lymphocyte",Rac GTPase-Specific Small Molecular Inhibitors," Project Narrative Rac GTPases have emerged as potential anti-cancer therapeutic targets by recent studies. The proposed work will pursue structure-based design of new chemical inhibitors of Rac GTPases by translating the mechanistic information obtained from the decade-long biochemical, structural, cell biological, and animal studies of Rac GTPases for anti-cancer therapy. Further, the proposed work will help establish a novel therapeutic concept that targeting Rac in leukemia stem cells could result in their mobilization from the niche. Our studies will raise a new possibility for future combinatory therapy in cancer research.",141341,DMP,Drug Discovery and Molecular Pharmacology Study Section,,10,255099,
7760953,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA001568-31,,NIDA:489408;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"KUCZENSKI, RONALD ;",1892477;,5R01DA001568,06/29/1976,01/31/2013,"3,4-Dihydroxyphenethylamine; 3,5 cyclic AMP synthetase; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; ATP pyrophosphate-lyase (cyclizing); Acoustic; Acoustics; Acute; Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Aggression; Aggressive behavior; Agonist; Aminalon; Aminalone; Amphetamines; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animal Welfare; Animals; Anxiety; Attenuated; Autoradiography; Behavior; Behavioral; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bibliography; Binding; Binding (Molecular Function); Blood Plasma; Brain; Butanoic acid, 4-amino-; Characteristics; Chronic; Clinical; Common Rat Strains; Complex; Computer Assisted; Connector Neuron; Corpus Striatum; Corpus striatum structure; Country; Crystal Meth; Custom; D1 receptor; D2 receptor; DAT; DAT dopamine transporter; DRD2; DRD2 Receptor; Data; Deoxyephedrine; Desoxyephedrine; Development; Disinhibition; Dopamine; Dopamine D1 Receptor; Dopamine D2 Receptor; Dose; Drug Exposure; Drug Kinetics; Drug usage; Drugs; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Exposure to; Fear; Fright; GABA; Human; Human, General; Hydroxytyramine; IACUC; IRBs; Impact, Environmental; Infusion; Infusion procedures; Institutional Animal Care and Use Committee; Institutional Review Boards; Intake; Intercalary Neuron; Intercalated Neurons; International; Interneurons; Internuncial Cell; Internuncial Neuron; Intravenous; Investigators; Lead; Legal; Link; Mammals, Rats; Man (Taxonomy); Man, Modern; Manias; Manic; Manic State; Manuscripts; Measures; Mediating; Medication; Methamphetamine; Method LOINC Axis 6; Methodology; Methylamphetamine; Modeling; Molecular Interaction; Monitor; N-Methylamphetamine; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Nucleus Accumbens; Output; Paranoia; Paranoid Disorders; Paranoid psychosis; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Physiologic pulse; Picrotoxin; Plasma; Play; Population; Pre-Clinical Model; Preclinical Models; Prefrontal Cortex; Preparation; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Protocols, Treatment; Psychoses; Psychotic Disorders; Psychotic Paranoia; Publications; Pulse; Putamen; RGM; Raclopride; Radioautography; Rat; Rattus; Receptor Protein; Receptors, Neurohumor; Regimen; Regulation; Relative; Relative (related person); Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Reticuloendothelial System, Serum, Plasma; Role; Schizoid Personality; Schizoid Personality Disorder; Scientific Publication; Self Administration; Self-Administered; Serum, Plasma; Simulate; Site; Stereotyped Behavior; Stimulus; Stress; Striate Body; Striatum; Structure of putamen; Study Type; Syndrome; System; System, LOINC Axis 4; TXT; Testing; Text; Time; Transmission; Treatment Protocols; Treatment Regimen; Treatment Schedule; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Vertebrate Animals; Vertebrates; Violence; abstracting; adenylcyclase; amygdaloid nuclear complex; attenuation; base; behavioral disinhibition; calbindin; computer aided; design; designing; digital; dopamine transporter; dopamine transporter proteins; drug use; drug/agent; expiration; extracellular; frontal cortex; frontal lobe; gamma-Aminobutyric Acid; heavy metal Pb; heavy metal lead; human subject; meth exposure; methamphetamine abuse; methamphetamine exposure; model organism; monoamine vesicular transport proteins; neuroadaptation; neurobiological; neuron toxicity; neuronal; neuronal toxicity; neurotoxicity; pathway; pre-clinical research; preclinical research; prepulse inhibition; programs; psychostimulant abuse; putamen; receptor; receptor expression; receptor function; response; schizoid; simulation; social; social role; stimulant abuse; striatal; study design; transcription factor; transmission process; vertebrata; vesicular monoamine transporter; violent; violent behavior",Behavioral Characterization of Acute and Chronic Amphetamine,,1568,ZRG1,Special Emphasis Panel,,31,489408,
7765563,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA003371-23,,NIDA:467231;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,FORT COLLINS,UNITED STATES,PSYCHOLOGY,04,785979618,US,CO,80523,COLORADO STATE UNIVERSITY-FORT COLLINS,"BEAUVAIS, FREDERICK ;",1867843;,5R01DA003371,09/01/1983,11/30/2013,"AOD use; Adolescent; Adolescent Youth; Alcohol Drinking; Alcohol Intoxication; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic Intoxication; Alcohols; American; American Indian; American Indians; Attitude; Awareness; Awarenesses; Back; Behavior; Chemical Class, Alcohol; Cognitive; Communities; Data; Dorsum; Drug Design; Drug usage; Drugs; Drunkenness; Drunkennesses; Effectiveness; Environment; Epidemiology; EtOH drinking; EtOH intoxication; Feedback; Frequencies (time pattern); Frequency; Funding; Goals; Indians, American; Individual; Inhalant dose form; Intervention; Intervention Strategies; Life; Linear Models; Marihuana; Marijuana Smoking; Mediating; Medication; Modeling; Nature; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Prevalence; Prevention; Prevention of violence; Prevention program; Prevention strategy; Preventive Intervention; Preventive strategy; Recommendation; Reservations; Role; Sampling; Schools; Series; Sex Characteristics; Sex Differences; Social Behavior; Survey Instrument; Surveys; Time; Tribal School; Tribes; Victimization; Violence; Work; Youth; Youth 10-21; adolescent substance use; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; american indian reservation; base; criminal behavior; design; designing; drinking; drug use; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol intoxication; ethanol product use; ethanol use; etoh use; gang; gender difference; indian reservation; inhalant; insight; interventional strategy; juvenile; juvenile human; nation reservation; native american reservation; preventional intervention strategy; public health relevance; reservation community; reservation school; reservation-based; rural area; sexual dimorphism (noncellular); social; social role; sociobehavior; sociobehavioral; substance use; theories; trend; tribal reservation; violence prevention; violent; violent behavior; youth substance use",Drug Use Among Young Indians: Epidemiology & Prediction,,3371,CIHB,Community Influences on Health Behavior,,23,467231,
7759192,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA003910-24,,NIDA:553309;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ANN ARBOR,UNITED STATES,PHARMACOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MOSBERG, HENRY ISAAC;",1881554;,5R01DA003910,08/01/1985,01/31/2013,"Achievement; Achievement Attainment; Active Follow-up; Affinity; Agonist; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; C-terminal; Clinical; Combining Site; Complement; Complement Proteins; Complex; Data; Dependence; Development; Drugs; Evaluation; Genetics-Mutagenesis; Grant; In Vitro; Investigation; Lead; Ligands; Medication; Modeling; Modification; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; ORL1 receptor; Opiate Peptides; Opioid; Opioid Peptide; Opioid Receptor; Orphan; Parents; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Property; Property, LOINC Axis 2; Proteins; Publishing; Reactive Site; Receptor Protein; Receptors, Opiate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, delta; Receptors, kappa; Recruitment Activity; Series; Site; Structure; Study models; Testing; Validation; analog; base; conformation; conformational state; design; designing; drug/agent; efficacy testing; follow-up; gene product; heavy metal Pb; heavy metal lead; improved; in vivo; insight; interest; member; opioid-receptor-like 1 protein; peptide structure; peptidomimetics; pharmacophore; public health relevance; receptor; recruit; scaffold; scaffolding; success",Conformation - Selectivity Relations of Opioid Peptides,,3910,ZRG1,Special Emphasis Panel,,24,553309,
7741735,R01,DA,5,,12/01/2009,11/30/2010,PA-06-069,5R01DA004334-24,,NIDA:1636763;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KIRK, GREGORY D;",8424777;,5R01DA004334,04/01/1987,11/30/2011,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Adherence; Adherence (attribute); Affect; African American; Afro American; Afroamerican; After Care; After-Treatment; Aftercare; Age; Anti-viral Drug Resistance; Anti-viral Drug Resistant; Antiretroviral Therapy, Highly Active; Antiviral Drug Resistance; Antiviral Drug Resistant; Area; Assay; Baltimore; Basic Research; Basic Science; Behavioral; Bioassay; Biologic Assays; Biological Assay; Black Populations; Black or African American; Blood Pressure, High; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Caring; Cessation of life; Characteristics; Chronic Disease; Chronic Illness; Clinic; Clinical; Clinical Research; Clinical Study; Cohort Studies; Collaborations; Communicating Junction; Communities; Comorbidity; Complement; Complement Proteins; Concurrent Studies; Crime; Data; Data Collection; Death; Development; Diabetes Mellitus; Disadvantaged; Disease; Disorder; Drug Resistance, Viral; Drug abuse; Drug usage; Drugs; Drugs, Illicit; Effectiveness; Epidemic; Epidemiology; Evaluation; Event; Foundations; Funding; Gap Junctions; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; HAART; HCV; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatic Disorder; Hepatitis C virus; Hepatitus C; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Hypertension; Illicit Drugs; Immunologic Deficiency Syndrome, Acquired; Immunologic, Immunochemical; Immunologics; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Incidence; Individual; Infrastructure; Inherited Predisposition; Inherited Susceptibility; Injecting drug user; Injection Drug User; Interdisciplinary Research; Interdisciplinary Study; Interruption; Interview; Intramural Program; Intramural Research Program; Intravenous; Investigation; Investigators; LAV-HTLV-III; Laboratories; Link; Liver diseases; Longitudinal Studies; Low-resistance Junction; Lymphadenopathy-Associated Virus; Mediating; Medicaid; Medical; Medical Inspection; Medical Records; Medication; Methods; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multidisciplinary Collaboration; Multidisciplinary Research; NIDA; National Institute of Drug Abuse; Natural History; Natural immunosuppression; Neighborhoods; Nexus; Nexus Junction; Organ; Organ System, Cardiovascular; Outcome; PROV; Pathogenesis; Patients; Pattern; Peer Review; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Examination; Population; Population Study; Procedures; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Provider; Publications; Regimen; Registries; Research; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Risk Factors; SIS; Scientific Publication; Sister; Smoking; Source; Staging; Structure; Study, Interdisciplinary; Substance abuse problem; T-Lymphotropic Virus Type III Infections, Human; Testing; Toxic effect; Toxicities; Transportation; Treatment Efficacy; Treatment Period; Update; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Venipunctures; Viral Drug Resistance; Viral hepatitis; Virus-HIV; Visit; Work; abstracting; abuse of drugs; abuse of substances; abused drugs; abuses drugs; aging population; anti-retroviral therapy, highly active; base; black American; chronic disease/disorder; chronic disorder; circulatory system; cohort; density; diabetes; disease/disorder; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; experience; follow-up; genetic etiology; genetic mechanism of disease; genetic vulnerability; hepatopathy; hyperpiesia; hyperpiesis; hypertensive disease; immunosuppression; improved; indexing; insight; liver disorder; long-term study; next generation; programs; prospective; repository; resistance to anti-viral; resistance to antiviral; resistant to anti-viral; resistant to antiviral; response; satisfaction; social; substance abuse; success; therapeutic efficacy; therapeutically effective; treatment adherence; treatment days; treatment duration; uptake; viral resistance",Natural History of HIV Infection in Injection Drug Users,,4334,ACE,AIDS Clinical Studies and Epidemiology Study Section,,24,1636763,
7776968,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA006278-18,,NIDA:487628;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,UPTON,UNITED STATES,,01,027579460,US,NY,119735000,BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB,"WANG, GENE-JACK ;",6811070;,5R01DA006278,02/01/1990,01/31/2012,"2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abscission; Abuse, Cocaine; Addiction, Drug; Address; Affect; Association Learning; Attenuated; Behavioral; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-; Binding; Binding (Molecular Function); Brain; Brain region; Cells; Chemical Dependence; Chronic; Cocaine; Cocaine Abuse; Corpus Striatum; Corpus striatum structure; D2 receptor; DAT; DAT dopamine transporter; DRD2; DRD2 Receptor; Dependence, Drug; Dopamine; Dopamine D2 Receptor; Dorsal; Drug Addiction; Drug Dependency; Drug Metabolic Detoxication; Drugs; Encephalon; Encephalons; Environment; Excision; Extirpation; Fire - disasters; Fires; Grant; Human; Human, General; Hydroxytyramine; Individual; Intravenous; Laboratories; Lead; Learning; Literature; Man (Taxonomy); Man, Modern; Measures; Medical Imaging, Positron Emission Tomography; Medication; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Methylphenidate; Molecular Interaction; Monitor; Nervous System, Brain; Nucleus Accumbens; PBO; PET; PET Scan; PET imaging; PETSCAN; PETT; Patient Self-Report; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Placebo Effect; Placebos; Positron Emission Tomography Scan; Positron-Emission Tomography; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proton Magnetic Resonance Spectroscopic Imaging; Raclopride; Rad.-PET; Relapse; Removal; Rewards; Self-Report; Sham Treatment; Stimulus; Striate Body; Striatum; Surgical Removal; Therapeutic; Work; abused drugs; conditioning; craving; design; designing; detoxification; dopamine transporter; dopamine transporter proteins; drug addict; drug of abuse; drug/agent; drugs abused; drugs of abuse; expectancy effect; expectation; expectation effect; experience; extracellular; habit learning; heavy metal Pb; heavy metal lead; nocebo; novel; placebo response; prevent; preventing; programs; psychostimulant; public health relevance; radioligand; resection; response; sham therapy; striatal",Studies in Cocaine Abuse, Narrative A better understanding of the mechanisms underlying the effects of expectation on drug effects will help develop strategies that may be able to counteract the enhanced saliency that drugs of abuse have on the drug-addicted subjects and help prevent craving and relapse.,6278,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,18,487628,
7765617,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA006470-18,,NIDA:335239;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,DETROIT,UNITED STATES,PHARMACOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"BANNON, MICHAEL J;",1868805;,5R01DA006470,04/01/1990,01/31/2013,"2 propylvalerate; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AAV vector; Animal Model; Animal Models and Related Studies; Animal Welfare; Autopsy; Behavior; Bibliography; Binding; Binding (Molecular Function); Biological Models; Body Tissues; Brain; Brain Diseases; Brain Disorders; Cell membrane; Chronic; Clinical; Cocaine; Complement; Complement Proteins; Country; Cytoplasmic Membrane; DA Neuron; DAT; DAT dopamine transporter; DNA Molecular Biology; Development; Disease; Disease Progression; Disorder; Dopamine; Dopamine neuron; Drug abuse; Drugs; Ecological impact; Employee Strikes; Encephalon; Encephalon Diseases; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genes, Regulator; Genetic Transcription; Goals; Human; Human, General; Hydroxytyramine; IACUC; IRBs; Impact, Environmental; In Situ; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Knowledge; Lead; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Membrane Proteins; Membrane-Associated Proteins; Mesencephalon; Messenger RNA; Mid-brain; Midbrain; Midbrain structure; Model System; Models, Biologic; Molecular; Molecular Biology; Molecular Interaction; Monitor; Names; Nerve Impulse Transmission; Nerve Transmission; Nervous System, Brain; Neuronal Transmission; Nucleus Accumbens; Pathologic Processes; Pathological Processes; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plasma Membrane; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; RNA Expression; RNA, Messenger; RNA, Small Interfering; Reagent; Regulator Genes; Research; Research Ethics Committees; Research Resources; Resources; Role; Sampling; Site; Small Interfering RNA; Specific qualifier value; Specified; Strikes; Strikes, Employee; Surface Proteins; Targetings, Gene; Therapeutic; Therapeutic Effect; Tissues; Trans-Activation (Genetics); Transactivation; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transcriptional Regulatory Elements; Up-Regulation; Vertebrate Animals; Vertebrates; abstracting; abuse of drugs; abuses drugs; addiction; adeno-associated viral vector; adeno-associated virus vector; disease/disorder; dopamine transporter; dopamine transporter proteins; dopaminergic neuron; drug/agent; expiration; heavy metal Pb; heavy metal lead; human subject; in vivo; insight; mRNA; model organism; necropsy; neuropsychiatric; neuropsychiatry; neurotransmission; new therapeutics; next generation therapeutics; novel therapeutics; plasmalemma; postmortem; programs; psychostimulant abuse; regulatory gene; response; siRNA; social role; stimulant abuse; trans acting element; transcription factor; transporter (molecular); treatment strategy; valproate; vertebrata",Cocaine-binding Dopamine Transporter: Molecular Biology,,6470,MNPS,Molecular Neuropharmacology and Signaling Study Section,,18,335239,
7752863,R01,DA,5,,01/01/2010,12/31/2010,PA-07-282,5R01DA006736-17,,NIDA:334125;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,IOWA CITY,UNITED STATES,ANESTHESIOLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"HAMMOND, DONNA L;",1887687;,5R01DA006736,03/01/1991,12/31/2013,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; 6,7-dinitroquinoxaline-2,3-dione; Abbreviations; Absence of pain sensation; Absence of sensibility to pain; Acids; Afferent Neurons; Affinity; Agonist; Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Arthritis; Award; Biochemical; Blood Serum; Brain; Brain Stem; Brainstem; CTAP; Caprine Species; Cell/Tissue, Immunohistochemistry; Cells; Central gray substance of midbrain; Cerebrospinal Fluid; Cognitive; Common Rat Strains; Coupled; Coupling; D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; D-Ala2-NMe-Phe4-Gly-ol Enkephalin; DAGO; DAGOL; DAMGE; DAMGO; DNQX; Data; Development; Dorsal Horn Cells; Dorsal Horn of the Spinal Cord; Dose; Drug Therapy; Drugs; EPSP; Emotional; Encephalon; Encephalons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; Enkephalins; Enteramine; Excitatory Postsynaptic Potentials; Exhibits; Feels no pain; Fluorescence; Freund's Adjuvant; Freund's Complete Adjuvant; Fugu Toxin; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GDP; GTP; GTP-Binding Proteins; GTP-Regulatory Proteins; Glutamates; Goals; Goat; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine 5'-(trihydrogen diphosphate); Guanosine 5'-Diphosphate; Guanosine Diphosphate; Guanosine Triphosphate; Hippophaine; Hyperalgesia; Hyperalgesic Sensations; IHC; IRK1 channel; Immunohistochemistry; Immunohistochemistry Staining Method; Immunostimulants, adjuvants, Freund's; Inflammatory; Injury; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; K+ Channels, Inwardly Rectifying; Knowledge; L-Glutamate; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-; L-tryptophan,tetrahydropteridine[{..}]oxygen oxidoreductase (5-hydroxylating); Label; Laboratories; Locus Coeruleus; Mammals, Goats; Mammals, Rats; Mediating; Medication; Membrane; Mesencephalic Central Gray; Midbrain Central Gray; NK-1 Receptors; NK1R; NKIR; Nature; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Dorsal Horn; Neurons, Posterior Horn; Neurons, Sensory; Neurotransmitters; No sensitivity to pain; Nociception; Nucleus Pigmentosus Pontis; Opioid; Opioid Receptor; Outcome; Output; Pain; Painful; Pathway interactions; Perchlorates; Periaqueductal Gray; Peripheral; Persistent pain; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phe-Cys-Tyr-Trp-Arg-Thr-Pen-Thr-NH2; Phosphate Buffer; Physiology; Population; Posterior Horn Cells; Potassium Channels, Inwardly Rectifying; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Rat; Rattus; Receptor Protein; Receptors, Neurokinin-1; Receptors, Opiate; Regulation; Research; SP-P Receptors; Saline; Saline Solution; Sensory Cell Afferent Neuron; Serotonin; Serum; Soft Tissue Injuries; Spinal cord posterior horn; Structure of locus ceruleus; Substance P Receptor; System; System, LOINC Axis 4; TAC1R; TACR1; TTX; Tachykinin Receptor 1; Tarichatoxin; Testing; Tetradotoxin; Tetrodotoxin; Tryptophan 5-monooxygenase; Tryptophan Hydroxylase; Tryptophan Monooxygenase; Tyr-Ala-Gly-(NMe)Phe-Gly-ol; Tyr-Met-Phe-His-Leu-Met-Asp-NH2; Up-Regulation; Up-Regulation (Physiology); Upregulation; Withdrawal; Work; analgesia; annulus of the aqueduct; arthritic; base; blue nucleus; chronic pain; chronic painful condition; connective tissue-activating peptide; deltorphin; dermenkephalin; drug/agent; experiment; experimental research; experimental study; hyperalgia; immunoreactivity; inflammatory pain; innovate; innovation; innovative; insight; inward rectifier potassium channel; locus ceruleus structure; membrane structure; midbrain central gray substance; neuronal; nociceptive; novel; patch clamp; pathway; periaqueductal gray matter; phenylalanyl--cysteinyl--tyrosyl-tryptophyl-arginyl-threonyl-penicillaminyl-threoninamide; postsynaptic; presynaptic; programs; public health relevance; puffer fish toxin; receptor; research study; response; spinal fluid; synthetic enzyme; triphosphate; tripolyphosphate; tryptophan 5 hydroxylase; tyrosyl-methionyl-phenylalanyl-histidyl-leucyl-methionyl-aspartamide",Opioid Mechanisms of Analgesia," Persistent pain of an inflammatory nature, such as that associated with arthritis or soft tissue injury, exacts a significant financial, emotional and physical toll on its sufferers. The results of these studies will identify how persistent pain changes the function of brainstem pathways that are critically involved in the regulation of nociception and the production of analgesia. Insights gain from this work will guide the development of new, more effective pharmacotherapies or cognitive approaches for the relief of persistent pain.",6736,SCS,Somatosensory and Chemosensory Systems Study Section,,17,334125,
7760950,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA007058-20,,NIDA:294915;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SOUTH ORANGE,UNITED STATES,BIOLOGY,10,079324315,US,NJ,070792646,SETON HALL UNIVERSITY,"CHANG, SULIE LIN;",7964295;,5R01DA007058,03/01/1992,01/31/2012,"ADRGND; AIDS; AIDS Virus; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; AT III-protease complex; Acetates; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Activator Protein-1; Acute Promyelocytic Leukemia; Adhesions; Adrenal Glands; Adrenals; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bacterial Infections; Binding; Binding (Molecular Function); Blood Plasma; Blood Serum; Blood leukocyte; Body Temperature; Body Tissues; Brain; Cell Culture Techniques; Cells; Chronic; Clinical; Clotting; Coagulation; Coagulation Process; Common Rat Strains; Contin, MS; Control Animal; Corticosterone; Data; Differentiation Factor, B-Cell; Encephalon; Encephalons; Endotoxins; Enhancer-Binding Protein AP1; Envelope Glycoprotein gp120, HIV; Exposure to; Figs; Figs - dietary; Funding; Gagging; Gene Transcription; Genes; Genetic Transcription; Genome; Glycoproteins; Goals; HIV; HIV Envelope Protein gp120; HIV-1; HIV-I; HIV1; HL-60; HL-60 Cells; HL60; HL60 Cells; HPGF; HTLV-III; HTLV-III gp120; Hepatocyte-Stimulating Factor; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Hybridoma Growth Factor; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Immune; Immune system; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Infumorph; Injection of therapeutic agent; Injections; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Investigators; Kadian; LAV-HTLV-III; LPS; Leukocytes; Lipopolysaccharides; Lymphadenopathy-Associated Virus; MGI-2; MSir; Macrophages, Peritoneal; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mediating; Messenger RNA; Modeling; Molecular; Molecular Interaction; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Myeloid Differentiation-Inducing Protein; Myeloid Leukemia, Acute, M3; Nervous System, Brain; Nervous System, Pituitary; Opioid; Opioid Receptor; Oramorph; Oramorph SR; PBO; Pathway interactions; Patients; Peritoneal Macrophages; Phorbol; Phorbols; Physiologic; Physiological; Pituitary; Pituitary Gland; Placebos; Plasma; Plasmacytoma Growth Factor; Predisposition; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Pressure; Pressure- physical agent; Production; Programs (PT); Programs [Publication Type]; Progranulocytic Leukemia; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proviruses; RNA Expression; RNA, Messenger; Rat; Rattus; Receptor Signaling; Receptors, Opiate; Receptors, Opioid, mu; Receptors, mu; Recombinants; Reflex, Pharyngeal; Research Personnel; Researchers; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Serum, Plasma; Roxanol; STAT3; STAT3 gene; Sepsis; Septic Shock; Serum; Serum, Plasma; Sham Treatment; Signal Pathway; Statex SR; Susceptibility; Testing; Therapeutic Intervention; Thrombin-Antithrombin Complex; Tissues; Transcription; Transcription Factor AP-1; Transcription, Genetic; Transgenic Organisms; Translating; Translatings; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus Diseases; Virus-HIV; White Blood Cells; White Cell; antithrombin III-protease complex; bacterial disease; bloodstream infection; body system, allergic/immunologic; clinical significance; clinically significant; cytokine; desensitization; env Protein gp120, HIV; gp120; gp120 ENV Glycoprotein; gp120(HIV); human T cell leukemia virus III; human T lymphotropic virus III; hypothalamic; in vivo; interferon beta 2; intervention therapy; intraperitoneal; language translation; mRNA; mRNA Expression; macrophage; model organism; morphine acetate; novel; opiate abuse; opioid abuse; organ system, allergic/immunologic; pathway; pressure; programs; promyelocytic leukemia; receptor expression; response; sham therapy; suprarenal gland; thrombin-antithrombin III complex; transgenic; treatment effect; viral infection; virus infection; virus protein; white blood cell; white blood corpuscle",Morphine Actions on the Immune System,,7058,ZRG1,Special Emphasis Panel,,20,294915,
7755861,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA007625-16,,NIDA:329670;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"DEADWYLER, SAMUEL A.;",1887844;,5R01DA007625,08/01/1992,12/31/2012,"Address; Affect; Ammon Horn; Animal Welfare; Animals; Behavioral Model; Behavioral Paradigm; Bibliography; Blood Coagulation Factor IV; CB1 Receptor; Ca++ element; Calcium; Cannabinoids, Endogenous; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Cognitive; Cornu Ammonis; Country; Data; Ecological impact; Electrodes; Endocannabinoids; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Evoked Potentials; Factor IV; Funding; Hippocampus; Hippocampus (Brain); IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Laboratories; Link; Mediating; Memory; Methods; Methods and Techniques; Methods, Other; Minor; Monitor; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Outcome; Pattern; Physiologic; Physiologic pulse; Physiological; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Pulse; Receptor Protein; Receptor, Cannabinoid, CB1; Regimen; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Role; Sampling; Slice; Subcellular Process; Synapses; Synaptic; Techniques; Technology; Time; Vertebrate Animals; Vertebrates; Work; abstracting; base; experiment; experimental research; experimental study; expiration; hippocampal; human subject; neuronal; new technology; programs; receptor; research study; response; social role; vertebrata",Electrophysiological Assessment of Cannabinois Receptors,,7625,NMB,Neurobiology of Motivated Behavior Study Section,,16,329670,
7749049,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA009157-15,,NIDA:330784;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN ANTONIO,UNITED STATES,PHARMACOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"GERAK, LISA R;",1971742;,5R01DA009157,03/15/1995,11/30/2012,"3 alpha, 5 beta-Tetrahydroprogesterone; 3 alpha-Hydroxy-5 beta-pregnan-20-one; 3-Hydroxypregnan-20-one; 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-; 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester; 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; Absolute ethanol; Affinity; Alcohol withdrawal syndrome; Alcohol, Ethyl; Animals; Anxiety; Assay; Attention; Attenuated; Behavioral; Benzodiazepine Compounds; Benzodiazepines; Bioassay; Biologic Assays; Biological Assay; Chronic; Clinical; Cognitive Discrimination; Data; Dependence; Diazepam; Discrimination; Discrimination (Psychology); Disease; Disorder; Dose; Drugs; ETOH; Effectiveness; Eltanolone; Ethanol; Evaluation; Flumazenil; Flumazepil; Grain Alcohol; Grant; Insomnia; Insomnia Disorder; Laboratory Study; Lead; Ligands; Macaca mulatta; Mammals, Rodents; Measures; Mediating; Medication; Methylcarbinol; Midazolam; Monkeys; Nature; Opioid; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Physiologic; Physiological; Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-; Pregnan-3alpha-ol-20-one; Pregnanolone; Pregnanolone, (3alpha,5beta)-isomer; Procedures; Receptor Protein; Relative; Relative (related person); Rhesus; Rhesus Macaque; Rhesus Monkey; Rodent; Rodentia; Rodentias; Site; Sleeplessness; Stimulus; Testing; Therapeutic Effect; Training; Valium; Withdrawal; alcohol withdrawal; design; designing; disease/disorder; drug discrimination; drug/agent; ethanol withdrawal; heavy metal Pb; heavy metal lead; improved; insight; man; man's; neurosteroids; prevent; preventing; receptor; receptor function; withdrawal from alcohol",Discriminative Effects of Benzodiazepine Withdrawal,,9157,NMB,Neurobiology of Motivated Behavior Study Section,,15,330784,
7755428,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA009457-13,,NIDA:298822;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,AURORA,UNITED STATES,PSYCHIATRY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"LEONARD, SHERRY ;",1892433;,5R01DA009457,07/01/1995,12/31/2011,"ARIA; Affect; Alleles; Allelomorphs; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Antimorphic mutation; Autopsy; Binding; Binding (Molecular Function); Biological; Brain; Brain region; Bungarotoxins; Cell Line; Cell Lines, Strains; Cell surface; CellLine; Chaperone; Cognition; Cognitive deficits; Cornu Ammonis; Country; Data; Disease; Disorder; Doctor of Philosophy; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drugs; Encephalon; Encephalons; Evaluation; Event; Exons; Family; GGF; GGF2; Genes; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; HGL; HRGA; Heregulin Gene; Hippocampus; Hippocampus (Brain); Human; Human Cell Line; Human, General; In Vitro; Individual; Intervening Sequences; Introns; Length; Linkage Disequilibrium; Linkage Disequilibriums; Man (Taxonomy); Man, Modern; Medication; Mental Patients; Mental disorders; Mental health disorders; Mentally Ill; Mentally Ill Persons; Messenger RNA; Modeling; Molecular Chaperones; Molecular Interaction; Mutation; NDF; NEU Differentiation Factor Gene; NRG1; NRG1 gene; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nicotine; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Non-smoker; Nucleus Accumbens; Oocytes; Ovocytes; Patients; Peptides; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Polymorphism (Genetics); Polymorphism, Genetic; Proteins; Psychiatric Disease; Psychiatric Disorder; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; RNA Splicing; RNA, Messenger; Reading Frames; Receptor Gene; Receptor Protein; Regulation; SMDF; Schizophrenia; Schizophrenic Disorders; Sensory Process; Smoke; Smoker; Smoking; Splicing; Surface; System; System, LOINC Axis 4; Testing; Tobacco; Tobacco Consumption; Tobacco use; Transfection; Translations; Unspecified Mental Disorder; Variant; Variation; Work; abused drugs; amygdaloid nuclear complex; brain control; cultured cell line; dementia praecox; disease/disorder; drug development; drug of abuse; drug/agent; drugs abused; drugs of abuse; gene product; genome mutation; hippocampal; mRNA; mental illness; mind control; mutant; necropsy; neuronal; nonsmoker; polymorphism; postmortem; premature; psychological disorder; receptor; receptor expression; schizophrenic; trafficking",Regulation of Alpha 7 Nicotinic Receptor Assembly in Human Smokers,,9457,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,13,298822,
7565976,R01,DA,5,,12/01/2009,11/30/2010,,5R01DA010017-08,,NIDA:300990;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LITTLE ROCK,UNITED STATES,PSYCHIATRY,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"OLIVETO BEAUDOIN, ALISON ;",1892427;,5R01DA010017,09/30/1997,11/30/2011,"1,4-dihydropyridine; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-; 1-(aminomethyl)cyclohexaneacetic Acid; 17-(Cyclobutylmethyl)morphinan-3,14-diol; 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-; 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-; 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester; 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester; Adalat; Adrenergic Agonists; Adrenergic Antagonists; Adrenergic Blockaders; Adrenergic Blockers; Adrenergic Receptor Agonist; Adrenergic Receptor Blockaders; Adrenergic alpha-Agonists; Adrenergic-Blocking Agents; Adrenolytic Agents; Adrenolytic Drugs; Adrenolytics; Adrenomimetics; Adverse effects; Agonist; Aminoacetic Acid; Analgesics, Non-Narcotic; Analgesics, Nonnarcotic; Anti-Adrenergics; Antiadrenergic Agents; Antiadrenergics; Attenuated; Behavioral; Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-; Binding; Binding (Molecular Function); Blood Pressure, Low; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Butorphanol; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Channels, L-Type; Calcium Channels, N-Type; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Chemical Structure; Clonidine; Cognitive Discrimination; Cycloserine; DETOX Adjuvant; DXM; Data; Detox; Detox-B Adjuvant; Detox-B SE Adjuvant; Detox-B Stable Emulsion; Dextromethorphan; Diagnostic Findings; Dihydromorphinone; Dihydropyridines; Dilaudid; Dilaudid HP; Diltiazem; Dimorphone; Discrimination; Discrimination (Psychology); Dose; Drug Therapy; Drugs; EAA Antagonists; Endo Brand of Naloxone Hydrochloride; Excitatory Amino Acid Antagonists; Glutamate Antagonists; Glutamate Receptor Antagonists; Glycine; Goals; Human; Human, General; Hydromorphon; Hydromorphone; Hydrostat; Hymorphan; Hypotension; Ion Channels, Calcium; Iproveratril; Isradipine; Klofenil; L-Type Calcium Channels; L-Type VDCC; L-Type Voltage-Dependent Calcium Channels; Laboratories; Lamepro Brand of Naloxone Hydrochloride; Laudacon; Laudicon; Long-Lasting Calcium Channels; Man (Taxonomy); Man, Modern; Medication; Methods; Modeling; Molecular Interaction; Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-; Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; N-Type Calcium Channels; N-Type VDCC; N-Type Voltage-Dependent Calcium Channels; NMDA; Nalbuphine; Naloxone; Narcan; Narcanti; Narcotic Antagonists; Neural-Type Calcium Channels; Neurontin; Nifedipine; Non-Narcotic Analgesics; Nonopioid Analgesics; Novolauden; Opiate Antagonist; Opiates; Opioid; Opioid Antagonists; Organ System, Cardiovascular; PBO; Patient Self-Report; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiologic; Physiological; Placebos; Procardia; Procedures; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Psychomotor Performance; R-4-Amino-3-isoxazolidinone; Receptor Antagonists, Adrenergic; Receptors, Calcium Channel Blocker; Relative; Relative (related person); Self-Report; Series; Sham Treatment; Signs and Symptoms; Stimulus; Testing; Training; Treatment Side Effects; United Drug Brand of Naloxone Hydrochloride; VDCC; Vascular Hypotensive Disorder; Vascular, Heart; Verapamil; Voltage-Dependent Calcium Channels; Withdrawal; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-; Yohimbine; alpha-Adrenergic Receptor Agonists; behavior measurement; behavioral measure; behavioral measurement; channel blockers; circulatory system; corynine; d-Methorphan; dihydropyridine; drug/agent; efficacy testing; gabapentin; improved; lofexidine; member; nonopioid; novel; opioid withdrawal; psychomotor function; quebrachine; response; sham therapy; side effect; therapy adverse effect; treatment adverse effect; treatment strategy",Opioid Antagonist Discrimination: A Model of Withdrawal,,10017,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,8,300990,
7762762,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA010214-13,,NIDA:337466;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MILWAUKEE,UNITED STATES,BIOPHYSICS,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"LI, SHI-JIANG ;",1881461;,5R01DA010214,09/30/1996,01/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Arts; BOLD response; Behavioral; Body Weight; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Cocaine; Code; Coding System; Coke; Cues; Decision Making; Development; Disease; Disorder; Dopamine; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Encephalon; Encephalons; Environment; Expectancy; Functional Magnetic Resonance Imaging; Human; Human, General; Hydroxytyramine; Image; Incentives; Intracellular Communication and Signaling; Lead; Learning; Left; Love; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Mesencephalon; Methods; Mid-brain; Midbrain; Midbrain structure; Modeling; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Nicotine; Nuclear Magnetic Resonance Imaging; Outcome; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Prefrontal Cortex; Process; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Reporting; Rewards; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Striatum, Ventral; Structure; System; System, LOINC Axis 4; Testing; Trust; Ventral Striatum; Work; Zeugmatography; abstracting; abused drugs; addiction; biological signal transduction; blood oxygen level dependent; blood oxygenation level dependent response; cocaine use; disease/disorder; dopamine system; drug of abuse; drug/agent; drugs abused; drugs of abuse; expectation; fMRI; heavy metal Pb; heavy metal lead; human subject; imaging; incentive; inducement; neural; neurobiological mechanism; neuroimaging; non-human primate; nonhuman primate; public health relevance; relating to nervous system; response; social; time interval; visual stimulus",Imaging Cocaine Valuations in the Human Brain by fMRI,,10214,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,13,337466,
7763251,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA010355-15,,NIDA:331898;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,KANSAS CITY,UNITED STATES,OTHER BASIC SCIENCES,05,010989619,US,MO,64110,UNIVERSITY OF MISSOURI KANSAS CITY,"WANG, QIANG ;",1901744;,5R01DA010355,09/16/1997,12/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Addiction, Drug; Agonist; Amphetamines; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animals; Behavior; Behavioral; Binding; Binding (Molecular Function); Brain; CREB; CREB1; CREB1 gene; Cell Communication and Signaling; Cell Signaling; Characteristics; Chemical Dependence; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Dependence, Drug; Development; Dorsal; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Addiction; Drug Dependency; Drug Therapy; Drug effect disorder; Drugs; Dynorphins; EC 2.7.2-; ERK 1; ERK1 Kinase; Encephalon; Encephalons; Event; Extracellular Signal-Regulated Kinase 1; Extracellular Signal-Regulated Kinases; Gene Expression; Gene Transcription; Genetic; Genetic Transcription; Genomics; Glutamates; Grant; HMG-20; HSV; Herpes Simplex Virus; Herpes labialis Virus; Herpesvirus hominis; High Mobility Protein 20; Homer protein; Human; Human, General; Hydrolysis; Injection of therapeutic agent; Injections; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Knockout Mice; L-Glutamate; Label; Locomotor Activity; MAP Kinase 3; MAP kinase; MAPK; MAPK3 Mitogen-Activated Protein Kinase; Macropain; Macroxyproteinase; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Mental disorders; Mental health disorders; Metabotropic Glutamate Receptors; Methods; Mice, Knock-out; Mice, Knockout; Microtubule-Associated Protein-2 Kinase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular; Molecular Interaction; Motor Activity; Multicatalytic Proteinase; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neurons; Neurotransmitters; Nucleus Accumbens; Null Mouse; P44MAPK; PSTkinase p44mpk; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphorylation; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Protein Phosphorylation; Protein-Serine-Threonine Kinase p44(mpk); Proteins; Proteosome; Psychiatric Disease; Psychiatric Disorder; PtdIns; Putamen; R01 Mechanism; R01 Program; RNA Expression; RPG; Rat; Rattus; Receptor Protein; Receptors, Metabotropic Glutamate; Regimen; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rodent; Rodentia; Rodentias; Role; Science of neurochemistry; Series; Signal Transduction; Signal Transduction Systems; Signaling; Simplexvirus; Specificity; Striate Body; Striatum; Structure of putamen; Substance abuse problem; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Transcription; Transcription, Genetic; Translating; Translatings; Translations; Transmission; Ubiquitin; Unspecified Mental Disorder; Viral; abuse of substances; abused drugs; addiction; behavioral sensitization; biological signal transduction; cell type; drug action; drug craving; drug of abuse; drug/agent; drugs abused; drugs of abuse; experiment; experimental research; experimental study; gene product; health economics; herpesvirus; human herpesvirus 1 group; in vivo; innovate; innovation; innovative; insight; interdisciplinary approach; language translation; mental illness; model organism; multicatalytic endopeptidase complex; neurochemistry; neuronal; novel; p44 (MAPK); p44 MAPK; protein expression; psychological disorder; psychostimulant; public health relevance; putamen; receptor; research study; response; social; social role; spatiotemporal; stem; striatal; substance abuse; trafficking; transcription factor; transgene expression; transmission process",Metabotropic Glutamate Regulation of Amphetamine Action,,10355,MNPS,Molecular Neuropharmacology and Signaling Study Section,,15,331898,
7743792,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA010462-13,,NIDA:289080;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SEE, RONALD E;",1886348;,5R01DA010462,04/10/1997,11/30/2012,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Addiction, Drug; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Welfare; Area; Behavior; Bibliography; Body Tissues; Brain; Budgets; Cannulas; Cell Nucleus; Chemical Dependence; Chronic; Cocaine; Common Rat Strains; Complex; Corpus Striatum; Corpus striatum structure; Country; Cues; Dependence, Drug; Drops; Drug Addiction; Drug Dependency; Drug usage; Drugs; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Extinction; Extinction (Psychology); Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; L-Tyrosine,tetrahydrobiopterin[{..}]oxygen oxidoreductase (3-hydroxylating); Laboratories; Location; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Mediation; Medication; Methods; Modeling; Negotiating; Negotiation; Nervous System, Brain; Nucleus; Nucleus Accumbens; Pharmaceutic Preparations; Pharmaceutical Preparations; Prefrontal Cortex; Principal Investigator; Programs (PT); Programs [Publication Type]; Publications; Putamen; Rat; Rattus; Receptors, Opioid, mu; Receptors, mu; Relapse; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Scientific Publication; Self Administration; Staining method; Stainings; Stains; Stimulus; Striate Body; Striatum; Structure of putamen; Study Type; Testing; Tissues; Training; Tyrosine 3-Monooxygenase; Tyrosine Hydroxylase; Vertebrate Animals; Vertebrates; Work; abstracting; abused drugs; amygdaloid nuclear complex; behavioral extinction; calbindin; cresyl violet; drug abstinence; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; experiment; experimental research; experimental study; expiration; human subject; immunocytochemistry; interest; neural circuit; neural circuitry; programs; putamen; research study; social role; striatal; striosome; study design; vertebrata",Striatal mechanisms of relapse to cocaine seeking,,10462,NMB,Neurobiology of Motivated Behavior Study Section,,13,289080,
7765541,R01,DA,5,,02/01/2010,01/31/2011,PA-05-054,5R01DA011276-13,,NIDA:301272;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HANOVER,UNITED STATES,ANESTHESIOLOGY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"DELEO, JOYCE A;",1862176;,5R01DA011276,07/15/1997,01/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adverse effects; Affect; Aged 65 and Over; Allergy; Analgesics, Opioid; Animal Model; Animal Models and Related Studies; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Astrocytes; Astrocytus; Astroglia; Autoimmune Status; Autoimmunity; Behavioral; Behavioral Assay; Blood monocyte; Blotting, Western; CD14; CD14 Antigen; CD14 Monocyte Differentiation Antigen; CD14 gene; CD14 molecule; CD14 receptor; CNS autoimmunity; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Central Nervous System; Clinical; Common Rat Strains; Cytokines, Chemotactic; Data; Development; Diabetes Mellitus; Elderly; Elderly, over 65; Event; Foundations; Funding; Future; Gene Expression Inhibitor; Generations; Glia; Glial Cells; HIV; HTLV-III; Homologous Chemotactic Cytokines; Hortega cell; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Hypersensitivity; IHC; INFLM; Immune; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Immunochemical; Immunologics; Inflammation; Injury; Intercrines; Intracellular Communication and Signaling; Investigators; Kolliker's reticulum; LAV-HTLV-III; Laboratories; Lead; Leukocyte Trafficking; Lumbar Portion of Spinal Cord; Lumbar Spinal Cord; Lumbar spinal cord structure; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Methods and Techniques; Methods, Other; Mice; Microglia; Mission; Modeling; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Murine; Mus; Myeloid Cell-Specific Leucine-Rich Glycoprotein; Natural Immunity; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neuropathy; Nociception; Non-neuronal cell; Oligonucleotides, Antisense; Operation; Operative Procedures; Operative Surgical Procedures; Opioid; Opioid Analgesics; Pain; Painful; Patient Care; Patient Care Delivery; Patients; Pb element; Peripheral; Peripheral nerve injury; Persistent pain; Pharmacopoeias; Physical Dependence; Play; Prevention; Process; Production; Proteins; QOL; Quality of life; RT-PCR; RTPCR; Rat; Rattus; Receptor, LPS; Receptor, Lipoglycan; Receptors, Lipopolysaccharide; Refractory; Research; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A2; Spinal; Stimulus; Surgical; Surgical Interventions; Surgical Procedure; Syndrome; TLR4 receptor; Tactile; Techniques; Testing; Time; Toll-4 receptor; Trauma; Treatment Side Effects; Virus-HIV; Western Blotting; Western Blottings; Western Immunoblotting; Work; Xenobiotics; advanced age; allodynia; biological signal transduction; cell type; central nervous system autoimmunity; chemoattractant cytokine; chemokine; chronic neuropathic pain; chronic pain; chronic painful condition; cytokine; design; designing; diabetes; effective therapy; elders; experience; gene product; geriatric; gitter cell; heavy metal Pb; heavy metal lead; improved; injury response; insight; interdisciplinary approach; late life; later life; mesoglia; microglial cell; microgliocyte; model organism; monocyte; multidisciplinary; nerve cement; nerve injury; neural injury; neuroinflammation; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuropathic; neuropathic pain; neutralizing antibody; new approaches; nociceptive; novel; novel approaches; novel strategies; novel strategy; older adult; older person; painful neuropathy; perivascular glial cell; prevent; preventing; protein blotting; response; response to injury; reverse transcriptase PCR; self recognition (immune); senior citizen; side effect; social role; standard care; stressor; surgery; therapy adverse effect; toll-like receptor 4; treatment adverse effect",Alternatives to Opioids for Chronic Pain: Part IV,,11276,SCS,Somatosensory and Chemosensory Systems Study Section,,13,301272,
7765508,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA011389-13,,NIDA:260741;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SALT LAKE CITY,UNITED STATES,PHARMACOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"FLECKENSTEIN, ANNETTE ;",1876473;,5R01DA011389,02/01/1998,12/31/2012,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AD/HD; ADHD; Affect; Amfebutamone; Amphetamines; Animals; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bupropion; Cocaine; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Crystal Meth; Cytolysis; D2 receptor; DA Neuron; DAT; DAT dopamine transporter; DRD2; DRD2 Receptor; Data; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Deoxyephedrine; Desoxyephedrine; Development; Dopamine; Dopamine D2 Receptor; Dopamine Reuptake Inhibitors; Dopamine Uptake Inhibitors; Dopamine neuron; Dose; Goals; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; In Vitro; Kinetic; Kinetics; Laboratories; Ligand Binding; Lysis; Mammals, Rats; Mediating; Membrane; Methamphetamine; Methylamphetamine; Methylphenidate; Modeling; N-Methylamphetamine; Nature; Nerve; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuronal Transmission; Neurons; Physiologic; Physiological; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Rat; Rattus; Recycling; Regimen; Regulation; Reporting; Role; Species Specificity; Striate Body; Striatum; Subcellular Fractions; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Therapeutic; VESCL; VMAT2 Protein; Vesicle; addiction; attention deficit hyperactive disorder; buproprion; cytotoxic; degenerative condition; degenerative disease; dopamine transporter; dopamine transporter proteins; dopaminergic neuron; gene product; immunoreactivity; in vivo; inhibitor; inhibitor/antagonist; insight; membrane structure; monoamine; neurodegenerative illness; neuronal; neurotoxic; neurotransmission; novel; psychostimulant; public health relevance; response; social role; striatal; trafficking; uptake; vesicular monoamine transporter 2",Psychostimulants and Monoamine Transporters,,11389,NMB,Neurobiology of Motivated Behavior Study Section,,13,260741,
7768503,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA011649-10,,NIDA:361517;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BLENDY, JULIE ANN;",1872939;,5R01DA011649,01/01/2000,01/31/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; ATF; Acute; Addiction, Drug; Addictive Behavior; Address; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Area; BDNF; Behavior; Behavioral; Brain; Brain region; Brain-Derived Neurotrophic Factor; CHIP assay; CRE Binding Protein; CREB; CREB Protein; CREB1; CREB1 gene; Cell Nucleus; Cell/Tissue, Immunohistochemistry; Cells; ChIP (chromatin immunoprecipitation); Chemical Dependence; Circulatory Collapse; Clinic; Cocaine; Contin, MS; Corticosterone; Corticotropin Releasing-Factor Receptors; Corticotropin-Releasing Hormone Receptors; Cues; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Dependence, Drug; Development; Drug Addiction; Drug Dependency; Drug usage; Drugs; Dynorphins; Encephalon; Encephalons; Experimental Designs; Exposure to; Extinction; Extinction (Psychology); Foot; Gene Expression; Gene Targeting; Genes; Genes, Immediate-Early; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; History; Human; Human, General; IHC; Immediate-Early Genes; Immunohistochemistry; Immunohistochemistry Staining Method; Infumorph; Investigation; Investigators; Isoforms; Kadian; Knock-out; Knockout; Label; Laboratories; Link; Location; MGC34632; MSir; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Mice, Mutant Strains; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Murine; Mus; Mutant Strains Mice; Mutation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neurons; Nicotine; Nucleus; Oramorph; Oramorph SR; Pathway interactions; Pattern; Pes; Pharmaceutic Preparations; Pharmaceutical Preparations; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Prevention of relapse; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Receptor Activation; Receptors, CRF; Receptors, CRH; Receptors, Corticotropin-Releasing Hormone; Recording of previous events; Regulation; Relapse; Research; Research Personnel; Researchers; Rewards; Role; Roxanol; Sampling; Science of neurochemistry; Screening procedure; Self Administration; Shock; Signaling Molecule; Site; Staging; Statex SR; Stress; Swimming; Targetings, Gene; Testing; Therapeutic; Translating; Translatings; Wild Type Mouse; abused drugs; activating transcription factor; addiction; amygdaloid nuclear complex; behavioral extinction; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; chromatin immunoprecipitation; circulatory shock; conditioning; disorder later incidence prevention; drug craving; drug of abuse; drug relapse; drug reward; drug use; drug/agent; drugs abused; drugs of abuse; foot; gene product; genetic analysis; genome mutation; language translation; model organism; mouse mutant; neural circuit; neural circuitry; neurochemistry; neuronal; novel; pathway; preference; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; protein activation; response; screening; screenings; social role; stressor; transcription factor",Molecular genetic analysis of drug addiction,,11649,NMB,Neurobiology of Motivated Behavior Study Section,,10,361517,
7756689,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA012165-08,,NIDA:548757;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,DENTISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"GARVEY, ARTHUR ;",1871803;,5R01DA012165,01/01/2000,01/31/2013,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-; Abstinence; Active Follow-up; Address; Amfebutamone; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bupropion; Cessation of smoking; Chronic; Chronic Disease; Chronic Illness; Cigarette; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Cognitive; Complex; Conditioning Therapy; Consensus; Counseling; Counselor; Data; Data Analysis, Statistical; Data Collection; Data Files; Data Interpretation, Statistical; Dependence, Nicotine; Dependence, Tobacco; Desitriptyline; Desmethylamitriptylin; Development; Disease model; Dose; Drug Therapy; Drugs; Education; Educational aspects; Emotional Depression; Event; Experimental Designs; Files, Data; Future; Goals; Intervention; Intervention Strategies; Investigators; Knowledge; Laboratories; Life Style Modification; Manuals; Manuscripts; Measurement; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Modeling; Nicotine Dependence; Nicotine Replacement Therapy; Nicotine Skin Patch; Nortriptyline; Outcome; Paper; Participant; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Population; Preparation; Prevalence; Principal Investigator; Procedures; Process; Professional counselor; Programs (PT); Programs [Publication Type]; Progress Reports; Protocol; Protocols documentation; Protocols, Treatment; Psychiatry; Publications; Questionnaires; RGM; Randomized; Recruitment Activity; Regimen; Relapse; Reporting; Reports, Progress; Research; Research Design; Research Personnel; Researchers; SUBGP; Sample Size; Sampling; Scientific Publication; Seminal; Smoker; Smoking; Smoking Cessation Intervention; Smoking and Tobacco Use Cessation Interventions; Social support; Staff Development; Statistical Data Analyses; Statistical Data Interpretation; Structure; Study Subject; Study Type; Subgroup; Suggestion; Supervision; Symptoms of depression; Testing; Time; Tobacco Dependence; Training; Treatment Period; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States; Universities; Woman; Work; base; behavior intervention; behavioral intervention; buproprion; cease smoking; chronic disease/disorder; chronic disorder; cigarette smoking; clinical investigation; computerized; depressive; depressive symptoms; design; designing; disorder model; drug/agent; efficacy testing; experience; follow-up; group counseling; improved; interventional strategy; meetings; nicotine addiction; nicotine patch; nicotine replacement; programs; randomisation; randomization; randomly assigned; recruit; response; smoke cigarette; smoking cessation; social support network; study design; success; tobacco addiction; treatment days; treatment duration; varenicline",Duration of Behavioral Counseling Treatment Needed to Optimize Smoking Abstinence,,12165,NIDA,Neuropharmacology Research Subcommittee,,8,548757,
7760948,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA012204-11,,NIDA:296149;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,IRVINE,UNITED STATES,OTHER BASIC SCIENCES,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"MARSHALL, JOHN FOSTER;",1882394;,5R01DA012204,02/05/1999,12/31/2012,"3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; Abuse, Amphetamine; Acquired brain injury; Acute; Address; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Affect; Age; Agonist; American; Amphetamine Abuse; Anatomic; Anatomical Sciences; Anatomy; Animals; Area; Assay; Basal Ganglia; Basal Nuclei; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood flow; Brain Injuries; Cells; Cellular injury; Cerebral cortex; Cerebrum; Cholinergic Agonists, Muscarinic; Chronic; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Crystal Meth; Cyclic AMP-Dependent Protein Kinases; D2 receptor; DRD2; DRD2 Receptor; Data; Deoxyephedrine; Dependence; Desoxyephedrine; Disturbance in cognition; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine D2 Receptor; Dopamine Drugs; Dopamine Receptor; Dopamine Receptor Agonists; Dopaminergic Agents; Dopaminergic Agonists; Dopaminergic Drugs; Dose; Drug abuse; Drug abuser; Drugs; ERK 1; ERK1 Kinase; Enteramine; Entorhinal Area; Entorhinal Cortex; Exposure to; Extracellular Signal-Regulated Kinase 1; Fore-Brain; Forebrain; G-Protein alpha Subunit; G-Proteins; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Expression; Genes, Immediate-Early; Goals; Golf; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Health; Hippophaine; History; Human; Human, General; Hydroxytyramine; Image; Immediate-Early Genes; Impaired cognition; Impairment; Injury; Intake; Intracellular Second Messengers; JNK; JNK1; JNK1A2; JNK21B1/2; Lead; MAP Kinase 3; MAP Kinase 8 Gene; MAPK3 Mitogen-Activated Protein Kinase; MAPK8; MAPK8 gene; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medication; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Memory; Metabolic; Methamphetamine; Methamphetamine dependence; Methylamphetamine; Microtubule-Associated Protein-2 Kinase; Misuses drugs; Mitogen-Activated Protein Kinase 3; Molecular Interaction; Motor Cortex; Movement; Muscarinic Agonists; N-Methylamphetamine; Nerve Cells; Nerve Unit; Neural Cell; Neurochemistry; Neurocyte; Neurons; P44MAPK; PKA; PRKM8; PSTkinase p44mpk; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Population; Preparation; Problem drug user; Prosencephalon; Protein Kinase A; Protein-Serine-Threonine Kinase p44(mpk); Rat; Rattus; Recording of previous events; Regimen; Research; Research Support; Risk; Role; SAPK1; Science of Anatomy; Science of neurochemistry; Second Messenger Systems; Second Messengers; Serotonin; Signal Pathway; Signal Transduction Pathway; Somatosensory Cortex; Specificity; Striate Body; Striatum; Structure of entorhinal cortex; Testing; United States; abuse of drugs; abuses drugs; anatomy; barrel cortex; body movement; brain damage; brain lesion (from injury); cAMP-Dependent Protein Kinases; cell damage; cell injury; cingulate cortex; cognitive dysfunction; cognitive loss; cognitively impaired; density; drug/agent; entorhinal cortex; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; imaging; in vivo; information processing; interest; meth exposure; methamphetamine abuse; methamphetamine exposure; neurochemistry; neuronal; neurotoxic; novel; p44 (MAPK); p44 MAPK; pathway; perceptual stimulus; physicochemical phenomena related to the senses; prevent; preventing; psychologic; psychological; psychostimulant; repair; repaired; research study; response; second messenger; sensory stimulus; social role; somatosensory; somesthetic sensory cortex; stellate cell; striatal",Methamphetamine Abuse and Cortical Cell Injury,"Approximately 12 million Americans age 12 and older have tried methamphetamine. Methamphetamine  abusers often show memory and other cognitive problems. Using rats, we are studying how the brain damage  caused by methamphetamine abuse occurs and might cause memory problems. Our goal is to discover  information useful in preventing or repairing this cognitive decline.",12204,NMB,Neurobiology of Motivated Behavior Study Section,,11,296149,
7758795,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA012237-10,,NIDA:354550;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"LOEBER, ROLF ;",1883358;,5R01DA012237,02/15/2000,12/31/2010,"0-11 years old; 12-20 years old; AOD use; Address; Adolescence; Affect; African American; Afro American; Afroamerican; Age; Aggression; Aggressive behavior; Alcohol abuse; Alcohol or Other Drugs use; Attitude; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Black Populations; Black or African American; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Child; Child Youth; Childhood; Children (0-21); Cognition; Cognitive; Communities; Comorbidity; Conduct Disorder; Conflict; Conflict (Psychology); Data; Dependence; Depression; Development; Distal; Drugs; Drugs, Nonproprietary; Emotional; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Expectancy; Family; Female; Funding; Future; Gender; Generic Drugs; Goals; Human, Child; Individual; Individual Differences; Investigation; Knowledge; Link; Measures; Medication; Mental Depression; Mental Health; Mental Hygiene; NIDA; NIMH; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neighborhoods; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Occidental; PTSD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Post-Traumatic Stress Disorders; Prevention; Probability; Problem behavior; Psychological Health; Psychopathology; RFP; Race; Racial Group; Request for Proposals; Research; Risk; Rolfing; Sampling; Sexual abuse; Staging; Stocks, Racial; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Substance Use Disorder; Substance abuse problem; Time; Tobacco Consumption; Tobacco use; United States; United States National Institute of Mental Health; Urban Population; abnormal psychology; abuse of substances; adolescence (12-20); alcohol problem; anti social; antisocial; behavioral control; behavioral problem; black American; children; cohort; cost; data management; design; designing; drug/agent; early adolescence; early initiation substance use; early onset substance use; ethanol abuse; follow up assessment; generic; girls; hazardous alcohol use; high risk; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; inattention; inattentiveness; male; neglect; pediatric; peer; population based; problem drinking; pubertal timing; racial and ethnic; racial/ethnic; risky sexual behavior; sex abuse; substance abuse; substance use; teacher; teenage; traumatic neurosis; white race; youngster",Development of Substance Use in Girls,,12237,ZRG1,Special Emphasis Panel,,10,354550,
7754647,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA012289-10,,NIDA:544505;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CARBONDALE,UNITED STATES,PSYCHOLOGY,12,939007555,US,IL,629014709,SOUTHERN ILLINOIS UNIVERSITY CARBONDALE,"GILBERT, DAVID G;",1898022;,5R01DA012289,09/30/1998,01/31/2011,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Abstinence; Address; Affect; Affective; Amfebutamone; Anhedonia; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Appetite; Area; Attention; Attenuated; Brain; Bupropion; CAPS; Capsules; Central Nervous System; Cessation Research; Cessation of smoking; Cigarette; Cingulate Gyrus; Cognitive; Collection; Cues; Dependence, Nicotine; Desire for food; Distraction; Dopamine; Drug Therapy; Drugs; EEG; Electroencephalography; Electromagnetic; Electromagnetics; Emotional; Emotional Depression; Encephalon; Encephalons; Endogenous depression; Event; Exhibits; Experimental Designs; Eye; Eyeball; Finding of distraction; Funding; Goals; Gyrus Cinguli; Hydrogen Oxide; Hydroxytyramine; Image; Individual; Individual Differences; Intervention; Intervention Strategies; Investigators; Knowledge; Lead; Left; Levarterenol; Levonorepinephrine; Measures; Medication; Methods and Techniques; Methods, Other; Modeling; Moods; NIDA; National Institute of Drug Abuse; Nature; Nervous System Physiology; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurobiology; Neurologic function; Neurological function; Nicotine; Nicotine Dependence; Nicotine Skin Patch; Nicotine Withdrawal; Noradrenaline; Norepinephrine; PBO; Parietal; Patient Self-Report; Pattern; Pb element; Performance; Personality; Personality Traits; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Placebo Control; Placebos; Prefrontal Cortex; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Questionnaires; Relapse; Relative; Relative (related person); Research; Research Personnel; Research Support; Researchers; Resolution; Rest; Rewards; Role; Sample Size; Self-Report; Sham Treatment; Site; Sleep disturbances; Smoke; Smoker; Smoking; Source; Stimulus; Stress; Structure of cingulate gyrus; Symptoms; Symptoms of depression; Techniques; Testing; Time; Treatment Period; Water; Withdrawal Symptom; Work; active method; approach behavior; base; biobehavior; biobehavioral; buproprion; capsule (pharmacologic); cease smoking; cingulate gyrus; clinical depression; craving; cue reactivity; density; depressive; depressive symptoms; design; designing; directed attention; directs attention; distraction; drug addiction therapy; drug/agent; emotional stimulus; expectation; experience; gaze; heavy metal Pb; heavy metal lead; hedonic; imaging; indexing; information processing; insight; interest; interventional strategy; nervous system function; neurobiological; neurobiological mechanism; nicotine addiction; nicotine patch; pleasure; programs; psychologic; psychological; reinforcer; response; sham therapy; smoking cessation; social role; theories; tomography; trait; treatment days; treatment duration; vigilance; visual information",NRT & Bupropion Mechanisms of Efficacy in Smokers,,12289,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,10,544505,
7743793,R01,DA,5,,12/01/2009,11/30/2010,,5R01DA012498-09,,NIDA:251282;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"HEMBY, SCOTT EDWARDS;",1887854;,5R01DA012498,02/20/2000,11/30/2011,"3(2H)-Isoxazolone, 5-(aminomethyl)-; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; 6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Active Follow-up; Address; Agarin; Agonist; Alkylation; Aminalon; Aminalone; Aminobutyric Acids; Antibodies; Area; Blotting, Western; Brain; Brain region; Butanoic Acids; Butanoic acid, 4-amino-; Butyric Acids; CNQX; Chemosensitization; Chemosensitization/Potentiation; Chronic; Cocaine; Common Rat Strains; Data; Diacetylmorphine; Diamorphine; Dopamine; Dose; Drug abuser; Drugs; Encephalon; Encephalons; Expression Profiling; Expression Signature; Extracellular Fluid; Extremities; Funding; GABA; GABA Receptor; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Proteins; Globus Pallidus; Glutamate Receptor; Glutamates; Heroin; Hydroxytyramine; Immunoblotting; Immunologic Deficiency Syndrome, Acquired; Injection of therapeutic agent; Injections; Intake; Intravenous; Investigators; Knowledge; L-Glutamate; Limb structure; Limbs; Mammals, Rats; Measurement; Measures; Medial; Mediating; Medication; Methods and Techniques; Methods, Other; Microdialysis; Misuses drugs; Modeling; Modification; Molecular Fingerprinting; Molecular Profiling; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Muscimol; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Non-Trunk; Nucleus Accumbens; Opiates; Opioid Receptor; Pantherine; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Potentiation; Prefrontal Cortex; Problem drug user; Procedures; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Propionic Acids; Protein Analysis; Protein Gene Products; Proteins; Public Health; Rat; Rattus; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Opiate; Receptors, gamma-Aminobutyric Acid; Reporting; Research; Research Personnel; Researchers; Role; SCHED; SUBGP; Schedule; Science of neurochemistry; Self Administration; Self-Administered; Structure; Subgroup; Techniques; Testing; Time; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Treatment outcome; Ventral Tegmental Area; Western Blotting; Western Blottings; Western Immunoblotting; Work; cocaine use; drug/agent; experiment; experimental research; experimental study; extracellular; follow-up; functional genomics; gamma-Aminobutyric Acid; gene product; in vivo; innervation; intravenous drug use; kainate; laser capture microdissection; molecuar profile; molecular signature; multidisciplinary; nerve supply; neuroadaptation; neurobiological; neurochemistry; neuronal; pallidum; programs; protein blotting; protein expression; public health medicine (field); receptor; research study; response; social role; therapeutic development; vector; ventral tegmentum",Neurobiology of Speedball Self-administration,,12498,NMB,Neurobiology of Motivated Behavior Study Section,,9,251282,
7771803,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA012568-12,,NIDA:1233803;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MEHTA, SHRUTI H;",6273324;,5R01DA012568,09/01/1999,01/31/2013,"6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-; AIDS; AIDS Antibodies; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Affect; African American; Afro American; Afroamerican; Aging; Ancillary Study; Anti-HIV Positivity; Baltimore; Behavioral; Biologic Marker; Biological; Biological Markers; Black Populations; Black or African American; Blood; Blood-Borne Pathogens; Bloodborne Pathogens; Buprenorphine; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Caring; Censuses; Chronic Disease; Chronic Illness; Cities; Clinical; Cohort Studies; Collaborations; Collection; Communities; Concurrent Studies; Data; Disease; Disorder; Drug usage; Drug user; Drugs; Economics; Enrollment; Epidemiology; Funding; Future; Gender; Grant; HCV; HCV infection; HIV; HIV Antibodies; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Prevention; HIV Seroconversion; HIV Seropositivity; HIV-Associated Antibodies; HIV/AIDS prevention; HTLV-III; HTLV-III Antibodies; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Antibodies; HTLV-III-LAV Infections; Health; Healthcare; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Heterogeneity; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IVDU; Immunologic Deficiency Syndrome, Acquired; Improve Access; Incidence; Individual; Infection; Infrastructure; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Interview; Intravenous; Investigation; Investigators; Kidney; LAV Antibodies; LAV-HTLV-III; Link; Liver; Longitudinal Studies; Lymphadenopathy-Associated Antibodies; Lymphadenopathy-Associated Virus; Maps; Measures; Medical; Medical Records; Medication; Methods; Molecular Marker; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NANBH; Neighborhoods; Organ System, Cardiovascular; Outcome; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Pathway interactions; Pattern; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Population; Preventive Intervention; Process; Productivity; Protocol; Protocols documentation; Publications; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Reticuloendothelial System, Blood; Risk; Risk Behaviors; Risky Behavior; Science of Statistics; Scientific Publication; Senescence; Signature Molecule; Source; Specimen; Statistics; T-Lymphotropic Virus Type III Antibodies, Human; T-Lymphotropic Virus Type III Infections, Human; Testing; Update; Urinary System, Kidney; Users, IV Drug; Vascular, Heart; Virus-HIV; Visit; abstracting; age dependent; age effect; age related; aging effect; antibody positive AIDS test; antigen positive AIDS test; at risk behavior; base; biomarker; black American; body system, hepatic; chronic disease/disorder; chronic disorder; circulatory system; cohort; communicable disease transmission; comparison group; design; designing; disease transmission; disease/disorder; drug use; drug/agent; enroll; experience; follow-up; hepatitis non A non B; hepatitis nonA nonB; high risk; improved; indexing; infectious disease transmission; insight; interest; interventional strategy; intravenous drug user; long-term study; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; organ system, hepatic; pathway; population based; prevent; preventing; preventional intervention strategy; renal; repository; residence; senescent; seropositive (AIDS test); social; statistics; success; trend",Incidence of HIV Infection in a Cohort of IV Drug Users,,12568,ACE,AIDS Clinical Studies and Epidemiology Study Section,,12,1233803,
7755436,R01,DA,5,,01/01/2010,12/31/2010,PA-07-286,5R01DA012845-08,,NIDA:689631;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOULDER,UNITED STATES,GENETICS,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"HEWITT, JOHN K;",1880367;,5R01DA012845,09/15/2000,12/31/2012,"12-20 years old; AOD use; Active Follow-up; Addiction, Drug; Address; Adolescence; Adolescent; Adolescent Youth; Adoption; Age; Age of Onset; Aggression; Aggressive behavior; Agreement; Alcohol or Other Drugs use; Application Context; Archives; Behavior; Behavioral; Behavioral Genetics; Biological; Bone callus; Bony Callus; California; Callus; Characteristics; Chemical Dependence; Clinical; Clinical Data; Collaborations; Colorado; Communities; Comorbidity; Conduct Disorder; DNA; DNA Data Banks; DNA Databanks; DNA Databases; Data; Data Banks; Data Bases; Data Collection; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, DNA; Dataset; Deoxyribonucleic Acid; Dependence, Drug; Dependence, Substance; Development; Developmental Biology; Disease; Disorder; Drug Addiction; Drug Dependency; Electronics; Family; Funding; GWAS; Genetic; Genetic Determinants of Behavior; Genetic Load; Genetic analyses; Genetics, Behavioral; Genotype; Health; Health Sciences; Heritability; History; Home; Home environment; IQ Deficit; Individual; Informatics; Institutes; Investigators; Leadership; Life; Literature; Marriage; Molecular; NIDA; National Institute of Drug Abuse; Neurocognitive; Neurocognitive Deficit; Parents; Pattern; Phenotype; Procedures; Process; Prospective Studies; Psychiatrist; Psychologist; Psychopathology; Qualifying; Recording of previous events; Research; Research Personnel; Researchers; Rice; Role; Sample Size; Sampling; Severities; Siblings; Site; Study models; Substance Addiction; Substance Use Disorder; TXT; Testing; Text; Transmission; Twin Multiple Birth; Twins; Universities; Washington; Work; abnormal psychology; abstracting; abuse neglect; adolescence (12-20); adolescent substance use; aged; anti social; antisocial; association test; base; behavior genetics; clinical data repository; clinical data warehouse; contextual factors; cost; data repository; disease/disorder; early onset; follow up assessment; follow-up; genetic analysis; genetic association; genetic epidemiology; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; juvenile; juvenile human; multidisciplinary; neglect and abuse; proband; relational database; repository; sharing data; social; social role; substance use; teenage; transmission process; whole genome association studies; whole genome association study; youth substance use",Genetics of Adolescent Antisocial Drug Dependence,,12845,BGES,Behavioral Genetics and Epidemiology Study Section,,8,689631,
7758346,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA013583-08,,NIDA:262935;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"COOP, ANDREW ;",6196275;,5R01DA013583,02/01/2001,01/31/2013,"4,8-Methanobenzofuro(2,3-a)pyrido(4,3-b)carbazole-1,8a(9H)-diol, 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, (8R-(4bS*,8alpha,8abeta,14bbeta))-; 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, (5alpha,7alpha(R))-; Agonist; Analgesics, Opioid; Animal Welfare; Bibliography; Binding; Binding (Molecular Function); Boots Brand of Naloxone Hydrochloride; Brain; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Chemicals; Chronic; Clinical; Clinical Treatment; Contin, MS; Country; Development; Dihydromorphinone; Dilaudid; Dilaudid HP; Dimorphone; Dose; Ecological impact; Encephalon; Encephalons; Endo Brand of Naloxone Hydrochloride; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Ethorphine; Etorphine; Goals; Hydromorphon; Hydromorphone; Hydrostat; Hymorphan; IACUC; IRBs; Impact, Environmental; Indoles; Infumorph; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kadian; Lamepro Brand of Naloxone Hydrochloride; Laudacon; Laudicon; Ligands; MSir; Method LOINC Axis 6; Methodology; Methylnaloxone; Modeling; Models, Molecular; Molecular Interaction; Molecular Models; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5alpha)-; Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-; Morphinans; Morphine; N-Methylnaloxone; Naloxone; Narcan; Narcanti; Narcotic Antagonists; Nervous System, Brain; Novolauden; Nucleic Acid Biochemistry, Molecular Modeling; Opiate Antagonist; Opiate Peptides; Opioid; Opioid Analgesics; Opioid Antagonists; Opioid Peptide; Opioid Receptor; Oramorph; Oramorph SR; Oxymorphone; Pain; Painful; Peptides; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein/Amino Acid Biochemistry, Molecular Modeling; R01 Mechanism; R01 Program; RPG; Receptors, Opiate; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, delta; Receptors, mu; Reporting; Research; Research Ethics Committees; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Rice; Roxanol; Severities; Statex SR; United Drug Brand of Naloxone Hydrochloride; Vertebrate Animals; Vertebrates; abstracting; analog; base; design; designing; expiration; human subject; molecular modeling; naltrindole; novel; pharmacophore; programs; trial regimen; trial treatment; vertebrata",Opiods with Delta Antagonist and Mu Agonist Activity,,13583,ZRG1,Special Emphasis Panel,,8,262935,
7763253,R01,DA,5,,02/01/2010,01/31/2011,PA-07-166,5R01DA013821-06,,NIDA:398661;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"SANNA, PIETRO P;",1878222;,5R01DA013821,09/29/2000,01/31/2013,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Abuse, Cocaine; Addiction, Cocaine; Addiction, Drug; Affect; Alleles; Allelomorphs; Be element; Be++ element; Behavioral; Beryllium; Biochemical; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Cocaine; Cocaine Abuse; Cocaine Dependences; Commit; Common Rat Strains; Dependence, Drug; Dependences, Cocaine; Development; Drug Addiction; Drug Dependency; Drug abuse; Drug usage; Drugs; Eating; Ectopic Expression; Electromagnetic, Laser; Encephalon; Encephalons; Epidemic; Esteroproteases; Feeding behaviors; Food; Food Intake; Funding; Gene Expression; Gene Expression Profile; Gene Targeting; Genes; Genes, Regulator; Genetic; Genomics; Goals; HB-GAM receptor; Human; Human, General; Hypothalamic structure; Hypothalamus; Ingestive Behavior; Intake; Intracellular Communication and Signaling; Investigation; Knockout Mice; Knowledge; Lasers; Lateral; Lateral Hypothalamic Nucleus; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medication; Metallopeptidases; Metalloproteases; Metalloproteinases; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Microdissection; Modeling; Molecular; Motivation; Murine; Mus; Mutant Strains Mice; N-syndecan; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurons; Null Mouse; Pathway interactions; Pattern; Peptidases; Peptide Hydrolases; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Proteases; Proteinases; Proteoglycan; Proteolytic Enzymes; Protocol; Protocols documentation; Radiation, Laser; Rat; Rattus; Regulation; Regulator Genes; Relapse; Research; Resistance; Role; Satiation; Satiations; Self Administration; Self-Administered; Signal Transduction; Signal Transduction Systems; Signaling; Societies; System; System, LOINC Axis 4; Targetings, Gene; Testing; Transcriptional Regulatory Elements; Transgenic Mice; Validation; Wild Type Mouse; Withdrawal; Work; abuse of drugs; abuses drugs; addiction; base; biological signal transduction; dependence relapse; drug use; drug/agent; feeding; feeding-related behaviors; gene expression signature; heparin-binding growth associated molecule receptor; hypothalamic; metalloproteinase (general); mouse mutant; mutant; neurobiological; neuronal; new therapeutic target; novel; nutrient intake activity; pathway; public health relevance; regulatory gene; resistant; response; satiety; social role; syndecan; syndecan 3; trans acting element; transcriptome",Gene expression of cocaine dependence and relapse,,13821,ZRG1,Special Emphasis Panel,,6,398661,
7759514,R01,DA,5,,01/01/2010,12/31/2010,PA-07-117,5R01DA013951-07,,NIDA:323428;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"WOODWARD, JOHN J;",1888363;,5R01DA013951,04/01/2001,12/31/2013,"0-11 years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Absolute ethanol; Action Potentials; Acute; Adhesives; Adolescent; Adolescent Youth; Adverse effects; Alcohol, Ethyl; Area; Arrhythmia; Aspiration, Respiratory; Attention; Behavior; Behavior Control; Behavioral Manipulation; Benzene, methyl-; Brain; Brain region; Breathing; Cardiac Arrhythmia; Cell Communication and Signaling; Cell Signaling; Cells; Child; Child Youth; Children (0-21); Co-culture; Cocultivation; Coculture; Coculture Techniques; Complex; Connector Neuron; DA Neuron; Death, Sudden; Detection; Dopamine; Dopamine neuron; Drugs; ETOH; Electrophysiology; Electrophysiology (science); Elements; Encephalon; Encephalons; Ethanol; Exposure to; Frequencies (time pattern); Frequency; Funding; Gated Ion Channel; Glues; Glurepsilon2; Glutamates; Grain Alcohol; Health; Heart Arrhythmias; Household; Human, Child; Hydroxytyramine; Impairment; In Vitro; Inhalation; Inhaling; Inspiration, Respiratory; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intoxication; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Knowledge; L-Glutamate; Legal; Ligands; Link; Maintenance; Maintenances; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane; Membrane Channels; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods and Techniques; Methods, Other; Methylcarbinol; Molecular; Motor output; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor 2B; NMDAR2B protein; NR2B N-Methyl-D-Aspartate receptor; NR2B NMDA receptor; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Transmission; Neurons; Neurophysiology / Electrophysiology; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nucleus Accumbens; Organic Solvents; Organic solvent product; Paint; Pathway interactions; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Prefrontal Cortex; Property; Property, LOINC Axis 2; Pyramidal neuron; Receptor Activation; Receptor Inhibition; Receptor Protein; Receptors, N-Methylaspartate; Recombinants; Research; Rewards; Role; Shapes; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slice; Solvents; Specificity; Stimulus; Sudden Death; Synapses; Synaptic; Synaptic plasticity; Syndrome; System; System, LOINC Axis 4; Techniques; Testing; Toluene; Transmission; Treatment Side Effects; V (voltage); Ventral Tegmental Area; abused drugs; addiction; behavioral control; biological signal transduction; children; cholinergic; dopaminergic neuron; drug of abuse; drug/agent; drugs abused; drugs of abuse; glutamate receptor epsilon 2 subunit; hippocampal pyramidal neuron; in vivo; inhalant abuse; inhalation drug abuse; inspiration; juvenile; juvenile human; knockout animal; membrane structure; neural; neuronal; neuronal excitability; neurotransmission; novel; patch clamp; pathway; prototype; public health relevance; receptor; receptor-mediated signaling; relating to nervous system; reward processing; side effect; sniffing drug; social role; therapy adverse effect; transmission process; treatment adverse effect; ventral tegmentum; voltage; working memory; youngster",Neural Actions of Toluene,  Project Narrative Abused inhalants are an important class of drugs of abuse that have received relatively little attention with respect to their mechanisms of action. Research to be carried out in this proposal will provide a detailed analysis of the effects of abused inhalants on neurons within brain areas involved in addiction.,13951,ZRG1,Special Emphasis Panel,,7,323428,
7768505,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA013997-08,,NIDA:370260;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"PAN, YING-XIAN ;",1881528;,5R01DA013997,04/01/2001,01/31/2013,"6-(0-acetyl)morphine; 6-O-monoacetylmorphine; 6-acetylmorphine; 6-monoacetylmorphine; Absence of pain sensation; Absence of sensibility to pain; Address; Affinity Chromatography; Agonist; Animal Model; Animal Models and Related Studies; Animals; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromatography, Affinity; Cis-Acting Locus; Cis-Acting Sequence; Common Rat Strains; Contin, MS; DNA; Deoxyribonucleic Acid; Diacetylmorphine; Diamorphine; Drug usage; Drugs; Eukaryota; Eukaryote; Exons; Feels no pain; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; GeneHomolog; Genes; Glucuronides; Goals; Heroin; Hogness Box; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Infumorph; Kadian; Knock-out; Knockout; Knowledge; MSir; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medication; Mice; Mice, Transgenic; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphine; Murine; Mus; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); No sensitivity to pain; Opioid; Opioid Receptor; Oramorph; Oramorph SR; Pain Control; Pain Therapy; Pain management; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Pre-mRNA; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Splicing; RNA, Messenger, Precursors; Rat; Rattus; Receptor Gene; Receptors, Opiate; Receptors, Opioid, mu; Receptors, mu; Regulation; Reporter; Role; Roxanol; Splicing; Statex SR; Structure; TATA Box; Targetings, Gene; Trans-Acting Factors; Trans-Activators; Transactivators; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Variant; Variation; abused drugs; affinity purification; analgesia; beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-yl; cis acting element; cultured cell line; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; eukaryotida; gene product; in vivo; insight; mRNA Precursor; model organism; morphine-6-acetate; morphine-6-glucuronide; morphine-6beta-glucuronide; mouse model; novel; premRNA; receptor internalization; response; social role; trans acting factor (genetic)","Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM",,13997,MNPS,Molecular Neuropharmacology and Signaling Study Section,,8,370260,
7846865,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA014845-07,,NIDA:674529;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,COLLEGE PARK,UNITED STATES,NONE,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"ARRIA, AMELIA M;",1873192;,5R01DA014845,09/30/2001,11/30/2013,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AOD use; Achievement; Achievement Attainment; Active Follow-up; Addiction, Opiate; Address; Adolescent; Adolescent Youth; Affect; Age; Alcohol or Other Drugs use; Alcohols; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Anxiety; Area; Articulation; Chemical Class, Alcohol; Clinical; Cocaine; DSM-IV; DSM4; Data; Data Collection; Data Set; Dataset; Decision Making; Delivery of Health Care; Dependence; Dependence, Opiate; Depression; Deterioration; Development; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Distal; Drops; Drug Prescribing; Drug Prescriptions; Drug abuse; Drug usage; Drug user; Drugs; Drugs, Illicit; Early treatment; Economically Deprived; Economically Deprived Population; Ensure; Equation; Exhibits; Family; Family Characteristics; Friends; Funding; Goals; Health; Health Care Utilization; Health Sciences, Allied and Health Services Delivery; Health Services; Healthcare Delivery; Heavy Drinking; Illicit Drugs; Individual; Infrastructure; Intervention; Intervention Strategies; Interview; Investments; Joints; Knowledge; Lead; Learning; Life; Literature; Longitudinal Studies; Measurement; Measures; Mediating; Medical; Medication; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Modeling; NIDA; National Institute of Drug Abuse; Natural History; Occupational; Opiate Addiction; Opiates; Outcome; Parents; Pattern; Pb element; Performance; Personal Satisfaction; Pharmaceutic Preparations; Pharmaceutical Preparations; Policy Maker; Prescriptions, Drug; Prevalence; Prevention; Preventive; Prospective Studies; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Public Health; Publications; Publishing; QOL; Quality of life; Research; Research Infrastructure; Resolution; Risk; Risk Factors; STD; Safety; Sampling; Schools; Scientific Publication; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Shapes; Social support; Societies; Staging; Structure; Students; Substance Use Disorder; System; System, LOINC Axis 4; Testing; Time; United States; Universities; Unspecified Mental Disorder; Venereal Diseases; Venereal Disorders; Venereal Infections; Work; Youth; Youth 10-21; abuse of drugs; abuses drugs; adult youth; alcohol use disorder; analgesia; base; cocaine use; cohort; college; college student; drink heavily; drug abuse prevention; drug addiction prevention; drug use; drug use prevention; drug/agent; economic cost; ethanol use disorder; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; follow-up; health care delivery; health care service; health care service utilization; health services utilization; healthcare service utilization; healthcare utilization; heavy alcohol use; heavy metal Pb; heavy metal lead; high risk; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; high school; improved; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; long-term study; meetings; mental illness; misuse of prescription only drugs; nonmedical use; opioid addiction; opioid dependence; peer influence; physical conditioning; pre-clinical; preclinical; prospective; psychological disorder; psychosocial; public health medicine (field); public health relevance; response; risky sexual behavior; social support network; substance use; success; treatment utilization; university student; well-being; young adult",Drug Abuse Trajectories in the Transition to Adulthood: Risk Factors and Outcomes,"  This renewal application to continue following a longitudinal cohort of 1253 college students has broad public health implications in that it focuses on three of the most significant health outcomes affecting young adults (i.e., drug abuse, mental disorders, and sexually transmitted diseases). The project will continue to measure a wide array of risk and protective factors, and is informed by a longitudinal developmental perspective; therefore, it has great potential for elucidating targets for drug abuse prevention in particular, and the delivery of health care services in general for young adults. Our ambitious and comprehensive approach will enable us to identify points at which problematic trajectories can be changed to avoid long-term consequences, enable young adults to fulfill their individual potential, and reduce unnecessary economic costs to society.",14845,BGES,Behavioral Genetics and Epidemiology Study Section,,7,674529,
7752786,R01,DA,5,,12/01/2009,11/30/2010,PA-07-307,5R01DA015013-07,,NIDA:647940;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,KANSAS CITY,UNITED STATES,PHARMACOLOGY,05,010989619,US,MO,64110,UNIVERSITY OF MISSOURI KANSAS CITY,"KUMAR, ANIL ;",6452368;,5R01DA015013,09/19/2001,11/30/2011,"AIDS; AIDS Seroconversion; AIDS Seropositivity; AIDS Vaccines; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Abuse, Morphine; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Addiction, Opiate; Address; Affect; Animal Model; Animal Models and Related Studies; Animals; Anti-HIV Positivity; Antiviral Agents; Antiviral Drugs; Antivirals; Blood; Blood Plasma Cell; Case Study; Cerebrum; Clinical; Contin, MS; Control Groups; DNA; DNA/MVA vaccine; Deoxyribonucleic Acid; Dependence, Opiate; Dependency; Dependency (Psychology); Development; Disease; Disease Progression; Disorder; Evolution; Exhibits; Future; Gagging; Guidelines; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immune; Immune response; Immunization; Immunologic Deficiency Syndrome, Acquired; Immunologic Monitoring; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Immunosurveillance; Individual; Inferior; Infumorph; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; Kadian; LAV-HTLV-III; Length of Life; Life; Longevity; Lymphadenopathy-Associated Virus; MSir; Macaca; Macaca mulatta; Macaque; Mediating; Modeling; Modified Vaccinia Ankara; Modified Vaccinia Virus Ankara; Monitor; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; Monkeys; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Morphine Abuse; Morphine Sulfate; Natural immunosuppression; Opiate Addiction; Opiates; Oramorph; Oramorph SR; Performance; Plasma Cells; Plasmacytes; Population; Predisposition; Reagent; Reflex, Pharyngeal; Reporting; Reticuloendothelial System, Blood; Rhesus; Rhesus Macaque; Rhesus Monkey; Roxanol; SHIV; SIV; Saline; Saline Solution; Sensitization, Immunologic; Sensitization, Immunological; Sexual Health; Simian Immunodeficiency Viruses; Solid; Statex SR; Susceptibility; System; System, LOINC Axis 4; T-Cell Subsets; T-Lymphocyte Subsets; Testing; Time; Transcript; United States; Vaccinated; Vaccination; Vaccines; Viral; Viral Burden; Viral Load; Viral Load result; Viral Pathogenesis; Virus; Virus Replication; Virus-HIV; Viruses, General; anti-viral efficacy; antibody positive AIDS test; antigen positive AIDS test; base; case report; clinical relevance; clinically relevant; cohort; design; designing; disease/disorder; drug addict; efficacy testing; emotional dependency; high risk; host response; immunoresponse; immunosuppression; immunosuppressive; life span; lifespan; model organism; non-human primate; nonhuman primate; opiate abuse; opioid abuse; opioid addiction; opioid dependence; oral vaccine; plasmocyte; seropositive (AIDS test); simian HIV; simian human immunodeficiency virus; vaccine candidate; vaccine efficacy; virus multiplication",Effects of Opiate on Virus/Host Responses in SHIV/Macaques,"This application proposes to test the efficacy of AIDS vaccine in morphine-dependent  macaques. The proposed studies are highly warranted because there is no information  available regarding effect of any vaccine in drug-addicted population. Therefore this  study will provide guidelines not only in setting of future AIDS vaccine, but also provide  guidelines regarding use of any vaccine in such high-risk population.",15013,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,7,647940,
7744708,R01,DA,5,,12/01/2009,11/30/2010,,5R01DA015096-08,,NIDA:323659;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,EMERYVILLE,UNITED STATES,,09,173995366,US,CA,94608,ERNEST GALLO CLINIC AND RESEARCH CENTER,"BONCI, ANTONELLO ;",6879253;,5R01DA015096,04/01/2002,11/30/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AMPA Receptors; Abstinence; Acute; Addictive Behavior; Bathing; Baths; Behavior; Brain; Chemosensitization; Chemosensitization/Potentiation; Cocaine; Common Rat Strains; Cyclic AMP Receptors; DA Neuron; Data; Development; Dopamine neuron; Encephalon; Encephalons; Event; Excitatory Synapse; Extinction; Extinction (Psychology); Food; Funding; Glutamates; Goals; Grant; Hour; In Vitro; Injection of therapeutic agent; Injections; L-Glutamate; Laboratories; Learning; Link; Long-Term Potentiation; Mammals, Rats; Mediating; Mediation; Memory; Molecular; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; Pathway interactions; Peptide Biosynthesis, Ribosomal; Phase; Physiologic; Physiological; Play; Potentiation; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Rat; Rattus; Receptors, AMPA; Receptors, Cyclic AMP; Role; Self Administration; Self-Administered; Series; Slice; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Testing; Time; Training; Ventral Tegmental Area; behavioral extinction; behavioral sensitization; cAMP Receptors; cocaine exposure; dopaminergic neuron; experiment; experimental research; experimental study; in vivo; neuronal; pathway; protein synthesis; receptor function; research study; response; social role; ventral tegmentum",Synaptic plasticity in the VTA after behavioral sensitization & cocaine self-admi,,15096,ZRG1,Special Emphasis Panel,,8,323659,
7778347,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA015214-09,,NIDA:311850;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"PIERCE, ROBERT CHRISTOPHER;",7107652;,5R01DA015214,04/01/2002,01/31/2013,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Address; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Analysis, Data; Animal Welfare; Animals; Behavior; Bibliography; Boston; Budgets; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Cell Nucleus; Cessation of life; City of Boston; Climate; Cocaine; Collection; Common Rat Strains; Cornu Ammonis; Country; D2 receptor; DA Neuron; DRD2; DRD2 Receptor; Data Analyses; Data Analysis, Statistical; Data Interpretation, Statistical; Death; Deep Brain Stimulation; Dopamine D2 Receptor; Dopamine neuron; Dose; Drugs; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Euthanasia; Funding; Globus Pallidus; Glutamates; Guidelines; Hippocampus; Hippocampus (Brain); Housing; IACUC; IRBs; ISA; Impact, Environmental; Independent Scientist Award; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; K-Awards; K-Series Research Career Programs; K02 Award; L-Glutamate; Mammals, Rats; Medial; Mediating; Medication; Mental disorders; Mental health disorders; Mercy Killing; Meteorological Climate; Methods; Methods and Techniques; Methods, Other; Minor; NIDA; NIH; National Institute of Drug Abuse; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurotransmitters; Nucleus; Nucleus Accumbens; Nucleus tegmentalis pedunculopontinus; Operation; Operative Procedures; Operative Surgical Procedures; Pedunculopontine Tegmental Nucleus; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Prefrontal Cortex; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Psychological reinforcement; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reinforcement; Reinforcement (Psychology); Relative; Relative (related person); Research; Research Career Program; Research Career Programs, K-Series; Research Ethics Committees; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Role; Salaries; Schools, Medical; Statistical Data Analyses; Statistical Data Interpretation; Study Section; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Testing; Time; Transmission; United States National Institutes of Health; Universities; Unspecified Mental Disorder; Ventral Tegmental Area; Vertebrate Animals; Vertebrates; Wages; Work; abstracting; amygdaloid nuclear complex; application in practice; cholinergic; climatic; cost; dopaminergic neuron; drug/agent; experiment; experimental research; experimental study; expiration; graduate student; hippocampal; human subject; medical schools; mental illness; nervous system disorder; neurological disease; neuronal; neuronal circuitry; novel; pallidum; practical application; programs; psychological disorder; research study; social role; surgery; transmission process; ventral tegmentum; vertebrata","mPFC, n. accumbens and and reinstatement of cocaine seeking",,15214,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,9,311850,
7762205,R01,DA,5,,12/01/2009,11/30/2010,PA-07-082,5R01DA015398-06,,NIDA:327638;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHAPEL HILL,UNITED STATES,PSYCHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"CURRAN, PATRICK J;HUSSONG, ANDREA M (contact);",2053987 (contact);2278007;,5R01DA015398,08/15/2002,11/30/2012,"0-11 years old; 12-20 years old; 5 year old; AOD use; Adolescence; Adolescent; Adolescent Youth; Affect; Age; Alcohol or Other Drugs use; Alcoholic; Alcoholism; Alcohols; Anxiety; Application Context; Archives; Behavioral; Boozer; Causality; Chemical Class, Alcohol; Child; Child Youth; Childhood; Children (0-21); Cognitive; Comorbidity; Data; Data Set; Dataset; Deceleration; Dependent drinker; Depressed mood; Depression; Development; Disease; Disorder; Drug usage; Drugs; Emotional Depression; Etiology; Family; Gender; Goals; Health behavior; Human, Child; Interview; Investigators; Life; Literature; Longitudinal Studies; Marihuana; Mediating; Medication; Mental Depression; Methods; Michigan; Modeling; Nursery Schools; Outcome; Parents; Participant; Pathway interactions; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Population; Prevention; Prevention program; Prevention strategy; Preventive strategy; Process; Research Personnel; Researchers; Risk; Risk Factors; SUBGP; Sampling; Sampling Studies; Schools, Nursery; Self Medication; Statistical Methods; Subgroup; Substance Use Disorder; Survey Instrument; Surveys; Symptoms; Symptoms of depression; Temperament; Testing; Time; Tobacco; Wood; Wood material; Youth; Youth 10-21; adolescence (12-20); age difference; aged; anti social; antisocial; children; children of alcoholics; cohort; college; contextual factors; depressed; depressive; depressive symptoms; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug use; drug/agent; effective intervention; emerging adult; experience; five year old; high risk; high school; juvenile; juvenile human; long-term study; novel; pathway; pediatric; population based; problem drinker; public health relevance; sadness; social; stressor; substance use; teenage; theories; trait; treatment program; youngster",Internalizing pathways to drug use: A multi-sample analysis, Project Narrative: Our proposal tests an internalizing pathway to substance use disorder over the first four decades of life. Studies of such early emerging but persistent pathways are rare but critical to efforts to design and implement effective intervention and treatment programs for youth.,15398,ZRG1,Special Emphasis Panel,,6,327638,
7754130,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA015718-07,,NIDA:371250;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"SCHOENBAUM, GEOFFREY M;",1915406;,5R01DA015718,09/01/2003,11/30/2013,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Drug; Affect; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals, Laboratory; Associative Learning; Behavior; Chemical Dependence; Chronic; Cocaine; Common Rat Strains; Conditioning, Classical; Conditionings, Classical; Cues; Data; Dependence, Drug; Drug Addiction; Drug Dependency; Drugs; Emotions; Fear; Food; Fright; Happiness; Happinesses; Laboratory Animals; Learning; Lesion; Maintenance; Maintenances; Mammals, Rats; Mediating; Medication; Nervous; Nucleus Accumbens; Outcome; Output; Pavlovian conditioning; Pharmaceutic Preparations; Pharmaceutical Preparations; Procedures; Process; Psychological reinforcement; Rat; Rattus; Recruitment Activity; Reinforcement; Reinforcement (Psychology); Relapse; Rewards; Role; Saccharose; Self Administration; Sucrose; Testing; Training; addiction; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; amygdaloid nuclear complex; classical conditioning; cocaine exposure; cocaine use; drug efficacy; drug/agent; experience; model organism; neural; neural circuit; neural circuitry; positive attitude; psychostimulant; recruit; reinforcer; relating to nervous system; response; social role",Corticolimbic encoding of conditioned reinforcers: relevance to addiction," NARRATIVE  Conditioned reinforcement is the process whereby cues that have been paired with primary rewards support the acquisition and maintenance of new instrumental responses. Abnormal responding to such cues is a prominent feature of drug addiction, where drug-associated cues motivate drug-taking and relapse in addicts and animal models. The efficacy of drug-associated cues in animal models depends on circuits that take information from the basolateral amygdala (ABL) to orbitofrontal cortex (OFC) or nucleus accumbens (NAc); however interpreting these data is hampered by our limited understanding of how these circuits (e.g. ABL-OFC or ABL-NAc) normally support conditioned reinforcement. Here, we will identify the different neural circuits mediating conditioned reinforcement and further localize the effects of chronic cocaine use on encoding of conditioned reinforcers in these circuits. The results will provide a neuroanatomical framework with which to better understand how reward-associated cues exert effects on behavior under normal (drug-na¨ve) conditions and after exposure to cocaine.",15718,NMB,Neurobiology of Motivated Behavior Study Section,,7,371250,
7796867,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA015966-05,,NIDA:784498;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,Beltsville,UNITED STATES,,05,021883350,US,MD,207053111,PACIFIC INSTITUTE FOR RES AND EVALUATION,"JOHNSON, KNOWLTON ;",8375628;,5R01DA015966,11/01/2002,01/31/2014,"Address; Adherence; Adherence (attribute); Adolescent; Adolescent Youth; Adopted; Aerosols; Alaska; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; Approaches to prevention; Arctic; Arctic Regions; Aspiration, Respiratory; Attention; Authorization; Authorization documentation; Behavior; Breathing; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Collaborations; Communities; Community Integration; Community Participation; Community Trial; Complex; Coughing; Curriculum; Development; Distal; Drops; Drug Prescribing; Drug Prescriptions; Drug usage; Drugs; Drugs, Non-Prescription; Drugs, Nonprescription; Education; Educational Curriculum; Educational aspects; Effectiveness; Ethnic group; Family; Feasibility Studies; Gasoline; Grant; Health; Home; Home environment; Household Products; Household Supplies; Infrastructure; Inhalant dose form; Inhalation; Inhaling; Inspiration, Respiratory; Intervention; Intervention Strategies; Legal; Letters; Manuscripts; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Medicine; Methods; Minnesota; Modeling; Mouthwash; NIH; National Institutes of Health; National Institutes of Health (U.S.); Native Alaskan; Non-Prescription Drugs; OTC Drugs; Occidental; Outcome; Over-the-Counter Drugs; Parents; Participation, Community; Patent Medicines; Permission; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Population; Population Sizes; Preparedness; Prescriptions, Drug; Prevalence; Prevention; Prevention approach; Problem behavior; Protocol; Protocols documentation; Publications; Randomized; Randomized Controlled Trials; Readiness; Regulation; Research; Research Design; Research Infrastructure; Rural; Schools; Science of Medicine; Scientific Publication; Study Type; System; System, LOINC Axis 4; Target Populations; Testing; Texas; United States; United States National Institutes of Health; Youth; Youth 10-21; adolescent substance abuse; base; behavioral problem; design; designing; dosage; drug use; drug/agent; effective intervention; efficacy testing; efficacy trial; evidence base; experience; frontier; inhalant; innovate; innovation; innovative; inspiration; instrument; interest; interventional strategy; juvenile; juvenile human; prevent; preventing; public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; study design; substance abuse prevention; tribal leader; white race; youth substance abuse",A Community Trial in Alaska to Prevent Youth's Use of Legal Products to Get High," Project Narrative  The testing of the proposed Community Prevention Model under experimental conditions is particularly significant because there are few evidence-based prevention models for frontier communities like those in Alaska, western Texas, or northern Minnesota. Further, there are even fewer evidence-based prevention models that target use of inhalants and other harmful legal products. In addition, the integration of community mobilization and environmental strategies focusing on retail outlets, homes, and schools is innovative and invites the entire community to assume responsibility for youth substance abuse prevention rather than assuming it is the responsibility of only the school system.",15966,CLHP,Community-Level Health Promotion Study Section,,5,784498,
7771804,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA017323-06,,NIDA:294685;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHICAGO,UNITED STATES,ANESTHESIOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"XU, MING ;",1976871;,5R01DA017323,09/01/2005,01/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Activator Protein-1; Addiction, Drug; Address; Attenuated; Behavioral; Binding Sites; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Chronic; Cocaine; Combining Site; Couples; D1 receptor; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Dependence, Drug; Disease; Disorder; Dopamine; Dopamine D1 Receptor; Dopamine Receptor; Dose; Drug Addiction; Drug Dependency; Drug Exposure; Drug abuse; Drugs; Encephalon; Encephalons; Enhancer-Binding Protein AP1; Exhibits; FOS gene; G0S7; Gene Expression; Gene Targeting; Genes; Genes, Immediate-Early; Genetic Alteration; Genetic Change; Genetic defect; Genetically Engineered Mouse; Goals; Hydroxytyramine; Immediate-Early Genes; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Laboratories; Mammals, Mice; Mediating; Medication; Mice; Mice, Mutant Strains; Modeling; Molecular; Murine; Mus; Mutant Strains Mice; Mutation; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Programs (PT); Programs [Publication Type]; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Proteins; Protooncogene FOS; Reactive Site; Receptor Gene; Receptor Protein; Recurrent disease; Relapsed Disease; Research Personnel; Researchers; Role; Science of neurophysiology; Self Administration; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Targetings, Gene; Testing; Transcription Factor AP-1; Transducers; Wild Type Mouse; Withdrawal; Work; abuse of drugs; abuses drugs; base; behavioral sensitization; biological signal transduction; c fos; c-fos Gene; c-fos Proto-Oncogenes; cocaine exposure; cocaine use; disease/disorder; dopamine system; drug induced behavior; drug/agent; effective therapy; experiment; experimental research; experimental study; functional genomics; gene product; genetic promoter element; genome mutation; insight; mouse model; mouse mutant; mutant; neuroadaptation; neuronal; neurophysiology; novel; programs; receptor; research study; response; social role; tool; treatment strategy; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Role of c-fos in cocaine actions,,17323,NMB,Neurobiology of Motivated Behavior Study Section,,6,294685,
7751239,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA017392-07,,NIDA:328680;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BRONX,UNITED STATES,NEUROSCIENCES,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CASTILLO, PABLO E;",6999145;,5R01DA017392,08/01/2003,11/30/2013,"Address; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Affect; Ammon Horn; Area; Axon Terminals; Behavioral; Binding; Binding (Molecular Function); Brain; Cannabinoids, Endogenous; Causality; Cell Communication and Signaling; Cell Signaling; Cognition; Cornu Ammonis; Cyclic AMP-Dependent Protein Kinases; Dentate Fascia; Dentate Gyrus; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Encephalon; Encephalons; Endocannabinoids; Epilepsy; Epileptic Seizures; Epileptics; Equilibrium; Etiology; Fascia Dentata; Feeding behaviors; Glutamates; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); In Vitro; Ingestive Behavior; Inhibitory Synapse; Intracellular Communication and Signaling; L-Glutamate; Learning; Lipids; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Synaptic Depression; Maintenance; Maintenances; Marihuana; Marijuana Abuse; Mediating; Mental disorders; Mental health disorders; Modification; Molecular; Molecular Interaction; Neocortex; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic; Neurological; Neurons; Neurophysiology - biologic function; PKA; Pain; Painful; Peptide Biosynthesis, Ribosomal; Perception; Physiologic; Physiological; Play; Prefrontal Cortex; Presynaptic Terminals; Process; Production; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase A; Protein Synthesis, Ribosomal; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Receptor Activation; Receptor Protein; Research; Rewards; Role; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Side; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Structure of dentate gyrus; Synapses; Synaptic; Synaptic Boutons; Synaptic Cleft; Synaptic Terminals; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Unspecified Mental Disorder; Work; balance; balance function; biological signal transduction; cAMP-Dependent Protein Kinases; cannabinoid receptor; dementia praecox; dentate gyrus; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; epilepsia; epileptiform; epileptogenic; experience; experiment; experimental research; experimental study; feeding-related behaviors; hippocampal; homotypical cortex; isocortex; long term depression; mental illness; motor control; neopallium; neural; neural function; neuronal; neurotransmitter release; new therapeutics; next generation therapeutics; novel; novel therapeutics; nutrient intake activity; postsynaptic; presynaptic; protein synthesis; psychological disorder; public health relevance; receptor; receptor coupling; relating to nervous system; research study; schizophrenic; social role",Presynaptic Forms of Long-Term Plasticity in the CNS," Endocannabinoids have emerged as key regulators of basic neural functions by mediating activity- dependent synaptic plasticity. Drugs that target these molecules and their receptors could be extremely useful for the development of new treatments for a variety of neurological and psychiatric disorders. Research on the endocannabinoid system not only helps in gaining a greater understanding of how marijuana acts in the brain and why it is abused, but it also provides new clues about how the brain works.",17392,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,7,328680,
7795245,R01,DA,5,,03/01/2010,02/28/2011,,5R01DA018247-05,,NIDA:350347;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,,53,078731668,US,CA,920371099,SALK INSTITUTE FOR BIOLOGICAL STUDIES,"HEINEMANN, STEPHEN FOX;",1875879;,5R01DA018247,03/01/2006,02/28/2011,"Abscission; Addiction, Drug; Affinity; Agonist; Animal Model; Animal Models and Related Studies; Behavior; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Biological Models; Brain; Cancer of Lung; Cardiac Diseases; Cardiac Disorders; Cessation of smoking; Chemical Dependence; Chronic; Cigarette; Combining Site; Country; Dependence; Dependence, Drug; Dependence, Nicotine; Depressed mood; Drug Addiction; Drug Dependency; Drugs; Encephalon; Encephalons; Epidemic; Excision; Exposure to; Extirpation; Family; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Health; Heart Diseases; Human; Human, General; In Vitro; Knowledge; Lead; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Methods; Mice; Model System; Models, Biologic; Molecular; Molecular Interaction; Murine; Mus; Mutation; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neuronal Transmission; Neurons; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Process; Property; Property, LOINC Axis 2; Proteins; Pulmonary Cancer; Pulmonary malignant Neoplasm; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Reactive Site; Receptor Protein; Receptor Up-Regulation; Recovery; Removal; Research; Rodent; Rodentia; Rodentias; Role; Self Administration; Smoker; Smoking; Smoking Behavior; Societies; Surgical Removal; System; System, LOINC Axis 4; Testing; Time; Tobacco Consumption; Tobacco use; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; addiction; cease smoking; cholinergic; combat; depressed; desensitization; design; designing; drug/agent; gene product; genome mutation; heart disorder; heavy metal Pb; heavy metal lead; lung cancer; model organism; neurobiological; neuronal; neurotransmission; nicotine addiction; novel therapeutic intervention; receptor; resection; response; sadness; smoking cessation; social role; tissue culture",Role of Brain Nicotinic Receptors in Addiction Behaviors,,18247,NMB,Neurobiology of Motivated Behavior Study Section,,5,350347,
7766276,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA018993-05,,NIDA:300867;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BUFFALO,UNITED STATES,PSYCHOLOGY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"READ, JENNIFER P;",6799694;,5R01DA018993,05/01/2006,01/31/2011,"AOD use; Active Follow-up; Address; Administrator; Affect; Alcohol or Other Drugs use; Alcohols; Buffaloes; Causality; Chemical Class, Alcohol; Clinical; Cognitive; Coping Skills; Data; Data Set; Dataset; Development; Drops; Drug usage; Drugs, Illicit; Environmental Factor; Environmental Risk Factor; Epidemiology; Etiology; Event; Female; Gender; Generalized Growth; Growth; History; Illicit Drugs; Individual; Internet; Intervention; Intervention Strategies; Investigation; Investigators; Learning; Link; Literature; Mails; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Modeling; Nature; Negotiating; Negotiation; On-Line Systems; Online Systems; Population; Preventive Intervention; Procedures; Programs (PT); Programs [Publication Type]; Reading; Recording of previous events; Reporting; Research; Research Personnel; Researchers; Risk; Risk Factors; Sampling; Screening procedure; Self Efficacy; Shapes; Site; Skills, Coping; Stress; Students; Survey Instrument; Surveys; Symptoms; Techniques; Technology; Testing; Time; Tissue Growth; Tobacco; Tobacco Consumption; Tobacco use; Trauma; Universities; WWW; Woman; adult youth; alcohol and other drug; base; college; college student; coping; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; environmental risk; experience; falls; follow-up; high risk; interventional strategy; longitudinal course; men; men's; online computer; ontogeny; preventional intervention strategy; programs; prospective; psychological distress; screening; screenings; sex; social; social cognitive theory; substance use; university student; web; web based; world wide web; young adult","Trauma, Trauma Sequelae, and Substance Use in College",,18993,BGES,Behavioral Genetics and Epidemiology Study Section,,5,300867,
7755437,R01,DA,5,,01/01/2010,12/31/2010,PAR-03-017,5R01DA019573-05,,NIDA:231555;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"HEBERLEIN, ULRIKE A;",6786252;,5R01DA019573,03/01/2006,12/31/2010,"21+ years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Addictive Behavior; Adult; Affect; Alleles; Allelomorphs; Behavior; Behavioral Paradigm; Brain; Brain region; CRR Domain; Candidate Disease Gene; Candidate Gene; Chronic; Circadian Rhythms; Cocaine; Cysteine Rich Region; Diurnal Rhythm; Dopamine; Drosophila; Drosophila genome; Drosophila genus; Drugs; Encephalon; Encephalons; Enzymes; Exposure to; Expression Profiling; Expression Signature; Flies; Fruit Fly, Drosophila; Funding; Gene Expression; GeneHomolog; Genes; Genetic; Genetic Screening; Genomics; Goals; Homeo Domain; Homeo Domain Proteins; Homeobox Family Protein; Homeobox Proteins; Homeodomain Family Protein; Homeodomain Proteins; Homeoproteins; Homeotic Proteins; Homolog; Homologous Gene; Homologue; Hour; Human, Adult; Hydroxytyramine; LIM Domain; Mammals, Mice; Measures; Mediating; Medication; Mice; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Murine; Mus; NIDA; NRVS-SYS; Names; National Institute of Drug Abuse; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System Physiology; Nervous System, Brain; Nervous system structure; Neural Cell; Neurochemistry; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurologic function; Neurological function; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Nicotine; Nyctohemeral Rhythm; Peptide Domain; Pharmaceutic Preparations; Pharmaceutical Preparations; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Property; Property, LOINC Axis 2; Protein Domains; Proteins; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RT-PCR; RTPCR; Receptors, Neurohumor; Resolution; Reverse Transcriptase Polymerase Chain Reaction; Rewards; Role; Science of neurochemistry; Sequence-Specific Posttranscriptional Gene Silencing; Series; Sleep Deprivation; System; System, LOINC Axis 4; Tertiary Protein Structure; Testing; Translating; Translatings; Twenty-Four Hour Rhythm; abused drugs; addiction; adult human (21+); behavior test; behavioral test; circadian; circadian process; cocaine exposure; daily biorhythm; diurnal variation; drug addict; drug induced behavior; drug of abuse; drug/agent; drugs abused; drugs of abuse; experiment; experimental research; experimental study; fly; fruit fly; gain of function; gene product; genome, Drosophila; genome, fruit fly; homeodomain; insight; intervention development; knock-down; language translation; molecuar profile; molecular signature; mutant; nervous system development; nervous system function; neural; neural mechanism; neurochemistry; neuromechanism; neuronal; novel; protein function; psychostimulant; receptor expression; relating to nervous system; research study; reverse transcriptase PCR; social role; therapy development; tool; treatment development",Molecular Genetics of Psychostimulant Action,,19573,ZRG1,Special Emphasis Panel,,5,231555,
7798502,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA019631-04,,NIDA:488589;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BUFFALO,UNITED STATES,PSYCHOLOGY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"COLDER, CRAIG R;",1871462;,5R01DA019631,09/30/2006,12/31/2011,"0-11 years old; 12 year old; 12-20 years old; 21+ years old; AOD use; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Alcohol or Other Drugs use; Behavioral; Brain; Care Givers; Caregivers; Child; Child Youth; Childhood; Children (0-21); Communities; Development; Dimensions; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Exposure to; Factor Analyses; Factor Analysis; Human, Adult; Human, Child; Individual; Informal Social Control; Intervention; Intervention Strategies; Investigators; Laboratories; Longitudinal Studies; Measures; Mediating; Modeling; Motivation; Nervous System, Brain; Only Child; Outcome; Pathway interactions; Pattern; Performance at work; Physiologic; Physiological; Preventive Intervention; Problem behavior; Programs (PT); Programs [Publication Type]; Public Health; Reporting; Research; Research Personnel; Researchers; Risk; Risk Behaviors; Risky Behavior; Role; Sampling; Self Regulation; Social Control, Informal; Social Environment; Substance abuse problem; Temperament; Testing; Time; Youth; Youth 10-21; abuse of substances; adolescence (12-20); adolescent substance use; adult human (21+); at risk behavior; base; behavioral problem; children; deviancy; deviant; environmental change; externalizing behavior; high risk; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; interest; interventional strategy; job performance; juvenile; juvenile human; long-term study; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; pathway; pediatric; peer; peer influence; preventional intervention strategy; programs; prospective; public health medicine (field); risky sexual behavior; social; social climate; social context; social role; socioenvironment; substance abuse; substance use; teenage; theories; twelve year old; work performance; youngster; youth substance use","Problem behavior, peers, and motivational aspects of temperament in substance use",,19631,ZRG1,Special Emphasis Panel,,4,488589,
7661666,R01,DA,5,,01/01/2010,12/31/2010,PA-00-045,5R01DA019632-04,,NIDA:539899;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BUFFALO,UNITED STATES,NONE,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"EIDEN, RINA D;",1887868;,5R01DA019632,08/01/2006,12/31/2011,"0-11 years old; 12-20 years old; AOD use; Accessory Sinuses; Accounting; Adolescence; Affect; Age; Age-Months; Alcohol or Other Drugs use; Analysis, Data; Area; Arousal; Attention; Attenuated; Autonomic nervous system; Autoregulation; Behavior; Behavioral; Birth; Blood Circulation; Bloodstream; Characteristics; Chemicals; Child; Child Development; Child Youth; Childhood; Children (0-21); Chronotropism, Cardiac; Chronotropisms, Cardiac; Cigarette; Circulation; Communication; Compliance behavior; Computer Systems Development; Conduct Disorder; Control Groups; Data Analyses; Development; Development, Computer Systems; Drug usage; Education; Educational aspects; Environment; Environmental Factor; Environmental Risk Factor; Environmental Tobacco Smoke; Exhibits; Exposure to; Family; Fetal Growth; Fetus; Frustration; Gestation; Goals; Growth, Fetal; Heart Rate; Heterogeneity; Homeostasis; Household; Human, Child; Infant; Infant and Child Development; Informal Social Control; Investigators; Language; Language Delays; Language Development; Lead; Life; Link; Maternal Age; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Modeling; Mothers; NIDA; NIH Program Announcements; Nasal Sinuses; Nasal cavity/Paranasal; Nasal cavity/Paranasal sinuses; National Institute of Drug Abuse; Negotiating; Negotiation; Nervous System Physiology; Neurologic function; Neurological function; Nicotine; Non-smoker; Outcome; Paranasal Sinuses; Parenting; Parenting behavior; Parents; Parturition; Pathway interactions; Patient Compliance; Patient Cooperation; Pb element; Perinatal Mortalities; Perinatal mortality demographics; Physiologic; Physiological; Physiological Homeostasis; Pregnancy; Problem behavior; Procedures; Program Announcement; Programs (PT); Programs [Publication Type]; Psychopathology; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Researchers; Risk; Role; Sampling; Self Regulation; Sinus; Sleep; Smoke; Smoker; Social Control, Informal; Stimulus; System; System, LOINC Axis 4; Systems Development; Time; Tobacco smoke; Toddler; Toxin; Treatment Compliance; Visual; Woman; abnormal psychology; abused drugs; acquiring language skills; addiction; adolescence (12-20); age at pregnancy; auditory stimulus; behavioral problem; children; cigarette smoking; compliance cooperation; design; designing; directed attention; directs attention; drug of abuse; drug use; drugs abused; drugs of abuse; environmental risk; environmental tobacco smoke exposure; heavy metal Pb; heavy metal lead; high risk; indexing; infancy; infantile; intrauterine growth; language acquisition; language learning; maternal cigarette smoking; maternal smoking; model development; nervous system function; non-smoking; nonsmoker; parental role; pathway; patient adherence; pediatric; postnatal; prenatal; prenatal exposure; prenatally exposed; programs; recruit; respiratory; response; role of parent; scaffold; scaffolding; second hand smoke; smoke cigarette; social role; substance use; teenage; therapy compliance; therapy cooperation; unborn; youngster",Prenatal & Environment Tobacco Smoke (ETS) Exposure: Effects on Child Regulation,,19632,ZRG1,Special Emphasis Panel,,4,539899,
7683906,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA020269-03,,NIDA:306976;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SALT LAKE CITY,UNITED STATES,PSYCHIATRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"YURGELUN-TODD, DEBORAH A.;",1871205;,5R01DA020269,09/10/2007,01/31/2012,"12-20 years old; 14 year old; 18 year old; 21+ years old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affective; Age; Age of Onset; Aminalon; Aminalone; Anterior; Behavioral inhibition; Biological Neural Networks; Brain; Brain region; Butanoic Acids; Butanoic acid, 4-amino-; Butyric Acids; Cannabinoids; Cannabis; Cell Communication and Signaling; Cell Signaling; Chemicals; Cognition; Cognitive; Cognitive deficits; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Decision Making; Development; Disease Frequency Surveys; Dorsal; Drug usage; Drugs; Drugs, Illicit; Dysfunction; Early treatment; Encephalon; Encephalons; Functional Magnetic Resonance Imaging; Functional disorder; GABA; H+ element; Hemp Plant; Human; Human, Adult; Human, General; Hydrogen Ions; Illicit Drugs; Imaging Procedures; Imaging Techniques; Impairment; Intracellular Communication and Signaling; Investigation; Lateral; Life; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRI, Functional; MRS; MRSI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Magnetic Resonance Spectroscopy; Man (Taxonomy); Man, Modern; Marihuana; Marijuana Abuse; Marijuana Smoking; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Memory; Methods and Techniques; Methods, Other; Motor; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocognitive; Neurocyte; Neurons; Neurotransmitters; Noise; Nuclear Magnetic Resonance Imaging; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Prefrontal Cortex; Process; Protons; Relative; Relative (related person); Reporting; Research; Resolution; Role; Science of neurophysiology; Signal Transduction; Signal Transduction Systems; Signaling; Smoking; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Staging; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Testing; Withdrawal; Zeugmatography; adolescence (12-20); adult human (21+); age dependent; age related; biological signal transduction; blood oxygen level dependent; cingulate cortex; cognitive function; cohort; design; designing; drug use; drug/agent; early onset; eighteen year old; executive control; executive function; fMRI; fourteen year old; frontal cortex; frontal lobe; gamma-Aminobutyric Acid; insight; interest; juvenile; juvenile human; morphometry; neural mechanism; neural network; neurobiological; neuromechanism; neuronal; neurophysiology; neuropsychological; non-smoking; pathophysiology; remediation; sex; social role; teenage",MRS/fMRI Investigations of Adolescent Cannabis Use,,20269,DBD,Developmental Brain Disorders Study Section,,3,306976,
7764736,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA020553-04,,NIDA:174283;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RICHMOND,UNITED STATES,PSYCHOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"SHELTON, KEITH L;",1896715;,5R01DA020553,04/10/2007,01/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-HT Receptors; 5-Hydroxytryptamine; 5-Hydroxytryptamine Receptors; 5HT; Acetylcholine; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Animals; Aspiration, Respiratory; Attenuated; Behavioral; Benzene, methyl-; Breathing; Cognitive Discrimination; Complex; Cues; Developing Countries; Developing Nations; Development; Discrimination; Discrimination (Psychology); Dopamine; Drug abuse; Drugs; Enteramine; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Exposure to; Hippophaine; Human; Human, General; Hydroxytyramine; Inhalant dose form; Inhalation; Inhalation Exposure; Inhaling; Inspiration, Respiratory; Less-Developed Countries; Less-Developed Nations; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical; Medication; Methods; Mice; Modeling; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Transmitter Substances; Neuromediator Receptors; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Opioid; Opioid Receptor; Pharmaceutic Preparations; Pharmaceutical Preparations; Procedures; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Neurohumor; Receptors, Opiate; Serotonin; Site; Speed; Speed (motion); Stimulus; System; System, LOINC Axis 4; Testing; Third-World Countries; Third-World Nations; Time; Toluene; Training; Trichloroethanes; Under-Developed Countries; Under-Developed Nations; United States; abuse of drugs; abused drugs; abuses drugs; base; drug discrimination; drug of abuse; drug/agent; drugs abused; drugs of abuse; inhalant; inhalant abuse; inhalation drug abuse; insight; inspiration; novel; receptor; serotonin receptor; sniffing drug; social; vapor",Discriminative stimulus effects of abused inhalants,,20553,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,4,174283,
7761665,R01,DA,5,,01/01/2010,12/31/2010,PAR-04-514,5R01DA020949-05,,NIDA:214701;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,STONY BROOK,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"SAMARAS, DIMITRIOS ;",8298549;,5R01DA020949,09/01/2005,12/31/2010,"3D image; Accounting; Addiction, Drug; Address; Aggression; Aggressive behavior; Animals; Articulation; Bayesian Networks; Behavior; Behavior Disorders; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Classification; Cognition; Complex; Computational Technique; Computer Architectures; Data; Data Set; Dataset; Dependence, Drug; Development; Diagnosis; Dimensions; Drug Addiction; Drug Dependency; Drugs; Emotions; Encephalon; Encephalons; Functional Magnetic Resonance Imaging; Future; Genotype; Human; Human, General; Images, 3-D; Impulsivity; Individual; Intracellular Communication and Signaling; Investigators; Joints; Lead; Learning; Learning, Machine; Left; Link; MRI, Functional; Machine Learning; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Maps; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Nervous System, Brain; Neurosciences; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Plant Roots; Population; Process; Programs (PT); Programs [Publication Type]; Research; Research Personnel; Researchers; Side; Signal Transduction; Signal Transduction Systems; Signaling; Systematics; Techniques; Testing; Three-Dimensional Image; addiction; approach behavior; assault; base; behavioral disorder; biological signal transduction; brain behavior; computer based statistical methods; drug/agent; fMRI; heavy metal Pb; heavy metal lead; improved; kernel methods; markov model; middle column; monoamine; network architecture; neuropsychological; novel; programs; response; root; statistical learning; statistical methods, computer based; support vector machine",Machine Learning for Analysis of functional MRI of Underlying Inhibitory Control,,20949,ZRG1,Special Emphasis Panel,,5,214701,
7771806,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA021249-03,,NIDA:321750;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"PECHNICK, ROBERT NELSON;",8309775;,5R01DA021249,04/01/2008,01/31/2013,"12-20 years old; 21+ years old; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Adult Children; Adult Daughters; Adult Sons; Adverse effects; Affect; Animals, Laboratory; Blood Plasma; Cause of Death; Cocaine; Common Rat Strains; Critical Period; Critical Period (Psychology); Dependence, Nicotine; Development; Dose; Drug Kinetics; Drug usage; Effects, Longterm; Environmental Tobacco Smoke; Exposure to; Fetal Development; Fetal Smoke Exposure; Fetal development of the mammalian embryo or fetus; Gene Down-Regulation; Gene Expression; Genes; Gestation; Gestational cigarette smoke exposure; Human, Adult; Individual; Intervention; Intervention Strategies; Laboratory Animals; Lead; Long-Term Effects; Maintenance; Maintenances; Mammals, Rats; Measures; Nerve Impulse Transmission; Nerve Transmission; Neurobiology; Neurochemistry; Neuronal Transmission; Nicotine; Nicotine Dependence; Nicotine Skin Patch; Offspring, Adult; Pb element; Pharmacokinetics; Plasma; Pregnancy; Pregnant Women; Prenatal Tobacco Smoke; Property; Property, LOINC Axis 2; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reticuloendothelial System, Serum, Plasma; Science of neurochemistry; Self Administration; Serum, Plasma; Smoke; Smoking; Testing; Tobacco smoke; Transcription Repression; Transcriptional Repression; Treatment Side Effects; United States; adolescence (12-20); adult human (21+); cigarette smoking; critical developmental period; critical period; drug abuse nicotine; drug use; environmental tobacco smoke exposure; epidemiologic data; experiment; experimental research; experimental study; fetal tobacco exposure; gene repression; heavy metal Pb; heavy metal lead; in utero; interventional strategy; juvenile; juvenile human; knowledge base; neurobehavioral; neurobiological; neurochemistry; neurotransmission; nicotine abuse; nicotine addiction; nicotine gum; nicotine patch; nicotine use in pregnancy; offspring; pregnant cigarette smoker; pregnant smoker; prenatal; prenatal cigarette smoking; prenatal exposure; prenatal influence; prenatal nicotine exposure; prenatal tobacco exposure; prenatally exposed; prenatally tobacco exposed; research study; response; second hand smoke; side effect; smoke cigarette; teenage; therapy adverse effect; tobacco use in pregnancy; treatment adverse effect; treatment strategy; unborn",Nicotine Addiction: Influence of Prenatal and Adolescent Exposure,,21249,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,3,321750,
7749576,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA021264-03,,NIDA:440202;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"POLING, JAMES ;",7602450;,5R01DA021264,06/10/2007,12/31/2012,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Adanon; Addiction, Cocaine; Address; Affect; Althose; Amfebutamone; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bupropion; Cells; Cephalon brand of modafinil; Cocaine; Cocaine Dependences; Cocaine Users; Cognitive; Combined Modality Therapy; Conditioning Therapy; Demethylimipramine; Dependences, Cocaine; Desipramine; Desmethylimipramine; Dolophine; Drug Therapy; Drug usage; Drugs; Euphoria; FDA approved; Fatigue; Goals; Human; Human, General; Individual; Intervention; Intervention Strategies; Investigators; Laboratories; Lack of Energy; Lead; Learning; Life Style Modification; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medication; Memory; Methadone; Methadose; Modafinil; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Opiates; Opioid; Out-patients; Outcome; Outpatients; PBO; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacotherapy; Phase; Placebo Control; Placebos; Population; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Provigil; Psychological reinforcement; Randomized; Randomized Clinical Trials; Reinforcement; Reinforcement (Psychology); Reinforcement Schedule; Research; Research Design; Research Personnel; Researchers; Role; Rosa; Rose; Sedation procedure; Sham Treatment; Study Subject; Study Type; Testing; Time; Toxicology; Trials, Randomized Clinical; Urinary System, Urine; Urine; Users, Cocaine; active method; base; behavior intervention; behavioral intervention; benzhydrylsulfinylacetamide; buproprion; clinical significance; clinically significant; cocaine use; combination therapy; combined modality treatment; combined treatment; comparative efficacy; contingency management; drug use; drug/agent; group intervention; heavy metal Pb; heavy metal lead; improved; interventional strategy; multimodality therapy; programs; randomisation; randomization; randomly assigned; sedation; sham therapy; social role; study design; success; synergism; treatment response; voucher",Pharmacotherapy & CM for Opioid and Cocaine Dependence,,21264,NIDA,Neuropharmacology Research Subcommittee,,3,440202,
7766278,R01,DA,5,,02/01/2010,01/31/2011,PA-07-123,5R01DA021379-03,,NIDA:336353;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,,08,080481880,US,NY,100103509,NATIONAL DEVELOPMENT & RES INSTITUTES,"DAVIS, WILLIAM R;",1875014;,5R01DA021379,02/01/2008,01/31/2011,"0-11 years old; 21 year old; 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Accent; Accounting; Active Follow-up; Adanon; Addiction, Opiate; Address; Age; Age Group Unspecified; Aging; Althose; Animal Welfare; Ataractics; Bibliography; Budgets; Categories; Cell Size; Child; Child Youth; Children (0-21); Chronic; Clinical; Cluster Analyses; Cluster Analysis; Cocaine; Cocaine Users; Complement; Complement Proteins; Complex; Consult; Consumption; Country; Critiques; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Collection; Dependence, Opiate; Diacetylmorphine; Diamorphine; Dihydrohydroxycodeinone; Disease Frequency Surveys; Dolophine; Drug abuse; Drug usage; Drug user; Drugs; Drugs, Illicit; Ecological impact; Ensure; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Ethnography; Euphoria; Europe; Evaluation; Exclusion; Family; Frequencies (time pattern); Frequency; Government; Grouping; Herb; Heroin; Heroin Users; History; Human, Child; IACUC; IRBs; Illicit Drugs; Impact, Environmental; Individual; Ingestion; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Interview; Investigation; Investigators; Link; Literature; Lorcet; Manuscripts; Marihuana; Marketing; Medicaid; Medical; Medication; Methadone; Methadose; Models, Statistical; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-; Motivation; Neighborhoods; Network Analysis; New York City; Opiate Addiction; Opioid; Oral; Oxycodeinon; Oxycodone; Oxycodone SR; Oxycontin; Pain; Pain Control; Pain Therapy; Pain management; Painful; Parental Consent; Pathway Analysis; Patients; Pattern; Persons; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacists; Pharmacologic Substance; Pharmacological Substance; Phase; Physicians; Pill; Pilot Projects; Policies; Population; Powder dose form; Powders; Principal Investigator; Prisons; Probabilistic Models; Programs (PT); Programs [Publication Type]; Publishing; Recording of previous events; Recruitment Activity; Relative; Relative (related person); Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respondent; Role; Route; Roxicodone; SCHED; SUBGP; Sales; Schedule; Senescence; Services; Social Network; Sorting - Cell Movement; Source; Statistical Models; Street Drugs; Subgroup; Supervision; Survey Instrument; Surveys; TXT; Target Populations; Text; Time; Tranquilizing Agents; Tranquillizing Drugs; Typology; United States; Update; Users, Cocaine; Users, Heroin; Variant; Variation; Vertebrate Animals; Vertebrates; Vicodin; Withdrawal; Youth; Youth 10-21; abstracting; abuse of drugs; abuses drugs; addiction; adult youth; age group; aged; base; children; convict; criminal offender; design; designing; drug market; drug use; drug/agent; ethnographic; experience; expiration; follow-up; groupings; high risk; human subject; innovate; innovation; innovative; insight; instrument; meetings; neglect; offender; opioid addiction; opioid dependence; opioid misuse; opioid withdrawal; pill (pharmacologic); pilot study; prescription drug abuse; prevent; preventing; programs; recruit; response; sedative; senescent; social role; sorting; theories; tranquilizer; twenty-one year old; vertebrata; young adult; youngster","Prescription Opioids Among Street Drug Users: Medical Use, Misuse & Diversion",,21379,CIHB,Community Influences on Health Behavior,,3,336353,
7749050,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA021420-04,,NIDA:344311;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,PSYCHIATRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"YAO, WEI-DONG ;",8389915;,5R01DA021420,04/10/2007,12/31/2010,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abuse, Cocaine; Addiction, Cocaine; Behavioral Paradigm; Brain; Brain Diseases; Brain Disorders; Candidate Disease Gene; Candidate Gene; Chronic; Cocaine; Cocaine Abuse; Cocaine Dependences; Complex; Dependences, Cocaine; Dopamine; Drug Exposure; Drug usage; Drugs; Encephalon; Encephalon Diseases; Encephalons; Environmental Factor; Environmental Risk Factor; Experimental Designs; Expression Profiling; Expression Signature; Gene Chips; Gene Expression; Gene Expression Chip; Gene Expression Profile; Genes; Genetics, in situ Hybridization; Genome; Glutamates; Hydroxytyramine; Immunoblotting; In Situ Hybridization; Individual; Injection of therapeutic agent; Injections; Intake; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; L-Glutamate; Macaca mulatta; Mammals, Mice; Mammals, Primates; Mediating; Medical; Medication; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Monkeys; Murine; Mus; Nervous System, Brain; Neurobiology; Neurochemistry; Outcomes Research; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Primates; Procedures; Regulation; Research; Research, Outcomes; Rewards; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Saccharose; Saline; Saline Solution; Science of neurochemistry; Self Administration; Self-Administered; Staging; Structure; Sucrose; System; System, LOINC Axis 4; Techniques; Testing; Time; addiction; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; cocaine exposure; cocaine use; density; dopamine system; drug use; drug/agent; effective therapy; environmental risk; gene expression signature; genome-wide; in situ Hybridization Staining Method; molecuar profile; molecular signature; neuroadaptation; neurobiological; neurochemistry; new approaches; non-drug; non-human primate; nonhuman primate; novel; novel approaches; novel strategies; novel strategy; recreational drug use; reinforcer; reward circuitry; social; social role; socioeconomic; socioeconomically; socioeconomics; theories; transcriptome",Molecular and Genetic Adaptations Associated with Compulsive Cocaine Intake,,21420,NMB,Neurobiology of Motivated Behavior Study Section,,4,344311,
7756624,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA021670-03,,NIDA:635656;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,UNIVERSITY PARK,UNITED STATES,OTHER HEALTH PROFESSIONS,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"HECHT, MICHAEL L;",1868806;,5R01DA021670,02/01/2008,01/31/2013,"Accounting; Address; Adoption; African American; Afro American; Afroamerican; Animal Welfare; Approaches to prevention; Assessment, Technology; Bibliography; Black Populations; Black or African American; Clinical Trials; Clinical Trials, Unspecified; Communities; Congresses; Control Groups; Country; Critiques; Curriculum; Data; Data Collection; Development; Dimensions; Drug resistance; Drug usage; Ecological impact; Educational Curriculum; Effectiveness; Effectiveness, Program; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Generalized Growth; Goals; Growth; Health; Hispanic Populations; Hispanics; Hispanics or Latinos; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Intervention Studies; Investigation; Investigators; Latino Population; Life; Linear Models; Literature; Measurement; Measures; Mediation; Modeling; Motivation; NIDA; NIH; National Institute of Drug Abuse; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Ohio; Outcome; Pennsylvania; Play; Population; Poverty; Prevention; Prevention approach; Prevention program; Preventive Intervention; Principal Investigator; Procedures; Process; Program Effectiveness; Programs (PT); Programs [Publication Type]; Quality of Health Care; Quality of Healthcare; Questionnaires; Randomized; Randomized Controlled Trials; Registries; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Risk Factors; Role; Rural; Rural Population; Schools; Spanish Origin; Structure; Students; Substance abuse problem; Technology Assessment; Testing; Tissue Growth; Training; United States National Institutes of Health; Urban Population; Variant; Variation; Vertebrate Animals; Vertebrates; Videotape; Work; Youth; Youth 10-21; abstracting; abuse of substances; base; black American; clinical investigation; design; designing; drug abuse prevention; drug addiction prevention; drug resistant; drug use; drug use prevention; effectiveness trial; efficacy trial; evidence base; experience; expiration; health care quality; hispanic community; human subject; improved; innovate; innovation; innovative; interventional strategy; metropolitan; middle school; novel; ontogeny; preventional intervention strategy; programs; randomisation; randomization; randomized controlled study; randomly assigned; resistance to Drug; resistant to Drug; social role; substance abuse; substance use prevention; teacher; universal interventions; universal prevention; universal preventive interventions; universal preventive measure; vertebrata",Adaptation Processes in School-Based Substance Abuse Program,,21670,ZRG1,Special Emphasis Panel,,3,635656,
7763257,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA021737-03,,NIDA:588306;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SEATTLE,UNITED STATES,NONE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HAGGERTY, KEVIN P;",8191978;,5R01DA021737,02/01/2008,01/31/2013,"12-20 years old; 21+ years old; ADRGND; AOD use; Accounting; Address; Adolescence; Adolescent; Adolescent Youth; Adrenal Glands; Adrenals; Adult; Aeroseb-HC; Affect; African American; Afro American; Afroamerican; Age; Aggression; Aggressive behavior; Alcohol or Other Drugs use; Alcohols; American; Animal Welfare; Animals; Application Context; Behavior; Bibliography; Biological; Biological Function; Biological Process; Black Populations; Black or African American; Caring; Cetacort; Characteristics; Chemical Class, Alcohol; Chronic stress; Code; Coding System; Complex; Consultations; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Country; Data; Data Sources; Dermacort; Development; Developmental Process; Drug abuse; Drug usage; Drugs; Ecological impact; Effects, Longterm; Eldecort; Environment; Environmental Impact; Equipment; Esthesia; Ethics Committees, Research; European; Exposure to; Family; Funding; Gender; Grant; HPA; Health; Human, Adult; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; IACUC; IRBs; Impact, Environmental; Individual Differences; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Knowledge; Laboratories; Life; Link; Literature; Long-Term Effects; Manuscripts; Measures; Medication; Methods; Modeling; Models, Theoretic; Monitor; NIDA; National Institute of Drug Abuse; Nervous System, Pituitary; Nutracort; Outcome; Parenting; Parenting behavior; Parents; Patient Self-Report; Pattern; Peer Group; Pharmaceutic Preparations; Pharmaceutical Preparations; Pituitary; Pituitary Gland; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Principal Investigator; Process; Proctocort; Productivity; Programs (PT); Programs [Publication Type]; Publications; Publishing; Questionnaires; Race; Racial Group; Regulation; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Review Literature; Risk Factors; Sampling; Scientific Publication; Self-Administered; Self-Report; Sensation; Sleep; Social Development; Sources, Data; Stocks, Racial; Stress; Substance abuse problem; System; System, LOINC Axis 4; Teen; Teenagers; Teens; Testing; Theoretical model; Therapeutic Hydrocortisone; Thinking; Thinking, function; Time; Treatment Efficacy; Vertebrate Animals; Vertebrates; Videotape; Violence; Writing; Youth; Youth 10-21; abstracting; abuse of drugs; abuse of substances; abuses drugs; adolescence (12-20); adult human (21+); allostatic load; base; biological adaptation to stress; black American; contextual factors; criminal behavior; critical period; drug use; drug/agent; emerging adult; emerging adulthood; expiration; group intervention; health disparities; health disparity; high risk; high risk behavior; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; high school; human subject; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; insight; intervention effect; interventional strategy; juvenile; juvenile human; meetings; middle school; peer; programs; protective behavior; race differences; racial difference; reaction; crisis; risky sexual behavior; sex; skills; social; stress buffering; stress management; stress response; stress; reaction; substance abuse; substance use; suprarenal gland; teen years; teenage; therapeutic efficacy; therapeutically effective; vertebrata; violent; violent behavior",Disparities of Drug Use in Emerging Adults,,21737,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,3,588306,
7751305,R01,DA,5,,01/01/2010,12/31/2010,,5R01DA021776-03,,NIDA:593698;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLOTTESVILLE,UNITED STATES,PSYCHIATRY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"AIT-DAOUD, NASSIMA ;",6492484;,5R01DA021776,09/01/2007,12/31/2012,"3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-; 5-HT; 5-HT-3; 5-HT3 Receptor; 5-HT3R; 5-Hydroxytryptamine; 5-Hydroxytryptamine (Serotonin) Receptor-3; 5-Hydroxytryptamine Receptor 3A; 5-Hydroxytryptamine-3 Receptor; 5-hydroxytryptamine (Serotonin) Receptor 3A; 5HT; 5HT3R; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Acute; Addiction, Cocaine; Address; Amphetamines; Anterior; Behavior Therapy, Cognitive; Behavioral; Behavioral Therapy; Brain Stem; Brain region; Brainstem; Cell Communication and Signaling; Cell Signaling; Cerebrovascular Circulation; Chronic; Clinical; Clinical Data; Cocaine; Cocaine Dependences; Cognitive Therapy; Data; Dependences, Cocaine; Dopamine; Dopamine Receptor; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; Enteramine; Female; Funding; HTR3; HTR3 Protein; HTR3A; Hippophaine; Human; Human, General; Hydroxytyramine; Individual; Intake; Intracellular Communication and Signaling; Investigators; Laboratories; Laboratory Study; Man (Taxonomy); Man, Modern; Measurable; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Medicine; Mission; Nerve Cells; Nerve Unit; Neural Cell; Neurochemistry; Neurocyte; Neurons; Ondansetron; Outcome; P46098; PBO; Patient Self-Report; Personal Satisfaction; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; Placebos; Programs (PT); Programs [Publication Type]; Psychological reinforcement; Psychostimulant dependence; Psychotherapy, Cognitive; QOL; Quality of life; Randomized; Randomized Controlled Trials; Receptors, Serotonin, 5-HT3; Reinforcement; Reinforcement (Psychology); Relapse; Research Personnel; Research Specimen; Researchers; Science of Medicine; Science of neurochemistry; Self Administration; Self-Report; Serotonin; Serotonin 3 Receptor; Serotonin 5-HT-3 Receptor; Serotonin-Gated Ion Channel Receptor; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Social Functioning; Specimen; Testing; Therapeutic; Therapy, Cognition; Translating; Translatings; Urinary System, Urine; Urine; Withdrawal; Withdrawal Symptom; Work; behavioral sensitization; benzoyl ecgonine; benzoylecgonine; biological signal transduction; brief intervention; cerebral blood flow; cerebral circulation; cerebrocirculation; cocaine use; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; craving; drug/agent; improved; language translation; male; neurochemistry; neuronal; pilot study; pre-clinical; preclinical; preclinical study; preference; programs; psychosocial; psychostimulant; psychostimulant addiction; randomisation; randomization; randomized controlled study; randomly assigned; restoration; sham therapy; stimulant addiction; stimulant dependence; well-being",New Medication Treatments for Stimulant Dependence,,21776,NIDA,Neuropharmacology Research Subcommittee,,3,593698,
7787520,R01,DA,5,,02/01/2010,01/31/2011,PA-07-329,5R01DA021779-02,,NIDA:530118;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MCCAUL, MARY E;",1871430;,5R01DA021779,03/15/2009,01/31/2014,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; Accounting; Acute; Affective Disorders; Age; Amphetamines; Androst-4-en-17beta-ol-3-one; Anxiety; Area; Basic Research; Basic Science; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Brain; Cannabinoids; Causality; Cessation of smoking; Chemicals; Chronic; Clinical; Corpus Luteum Hormone; Corpus Striatum; Corpus striatum structure; Crystal Meth; Delta4-androsten-17beta-ol-3-one; Delta4-pregnene-3,20-dione; Deoxyephedrine; Depression; Desoxyephedrine; Disease; Disorder; Dopamine; Drug usage; Drugs; Encephalon; Encephalons; Enteramine; Epidemiology; Estrogenic Agents; Estrogenic Compounds; Estrogens; Etiology; Female; Follicular Phase; Gender; Gonadal Steroid Hormones; High Prevalence; Hippophaine; Hormonal; Household; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hydroxytyramine; Idiopathic Parkinson Disease; Intervention; Intervention Strategies; Investigation; Laboratories; Lewy Body Parkinson Disease; Life; Luteal Phase; Man (Taxonomy); Man, Modern; Measures; Medical Imaging, Positron Emission Tomography; Medication; Menstrual Cycle, Follicular Phase; Menstrual Cycle, Luteal Phase; Menstrual Cycle, Secretory Phase; Menstrual Proliferative Phase; Menstrual Secretory Phase; Menstrual cycle; Menstrual cycle, proliferative phase; Mental Depression; Methamphetamine; Methylamphetamine; Mood Disorders; Moods; N-Methylamphetamine; Nerve Transmitter Substances; Nervous System, Brain; Neurologic; Neurological; Neurotransmitters; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Opioid; Ovarian Steroid Hormone; PET; PET Scan; PET imaging; PETSCAN; PETT; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Personality; Pharmaceutic Preparations; Pharmaceutical Preparations; Positron; Positron Emission Tomography Scan; Positron-Emission Tomography; Postovulatory Phase; Pregn-4-ene-3,20-dione; Pregnenedione; Preovulatory Phase; Prevention; Primary Parkinsonism; Procedures; Progesterone; Progressive Chorea, Hereditary, Chronic (Huntington); Proton Magnetic Resonance Spectroscopic Imaging; Public Health; Raclopride; Rad.-PET; Reporting; Research; Rewards; Role; Saline; Saline Solution; Scanning; Schizophrenia; Schizophrenic Disorders; Serotonin; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Solid; Stress; Striate Body; Striatum; Substance abuse problem; Survey Instrument; Surveys; System; System, LOINC Axis 4; Technology; Testosterone; Therapeutic; Therapeutic Estrogen; Therapeutic Progesterone; Therapeutic Testosterone; Tobacco smoking; Toxic effect; Toxicities; Trans-Testosterone; Woman; abuse of substances; addiction; adult youth; base; cease smoking; dementia praecox; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug use; drug/agent; gender difference; gonadal steroids; human subject; interventional strategy; male; men; men's; mesolimbic system; neuroimaging; neuron toxicity; neuronal toxicity; neuropsychiatric; neuropsychiatry; neurosteroids; neurotoxicity; proliferative phase Menstrual cycle; psychologic; psychological; public health medicine (field); public health relevance; response; schizophrenic; sex steroid; sexual dimorphism (noncellular); smoking cessation; social role; stressor; striatal; substance abuse; young adult",Gender Effects on Amphetamine-Induced Dopamine Release and Subjective Responses,"  Our laboratory has recently found that healthy, young adult men release more dopamine, a brain chemical that influences the rewarding and euphoric effects of stimulant drugs, and report greater ""high"" and ""drug liking"" following amphetamine administration compared with age-matched women. The proposed research will study these sex differences, whether the effects of amphetamine change in women during the menstrual cycle, and the role of sex hormones (estrogen, progesterone and testosterone) in modifying drug effects on dopamine. Findings will have considerable public health significance in furthering our understanding of normal sex differences in brain function and hormonal mechanisms for these effects, thus paving the way to better understand these factors in substance abuse and other neuropsychiatric disorders.",21779,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,530118,
7758827,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA021785-02,,NIDA:368651;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MASON, GRAEME F;",1933951;,5R01DA021785,01/15/2009,11/30/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Abstinence; Acute; Affect; Affective Disorders; Alcohol dependence; Alcoholism; Aminalon; Aminalone; Aminobutyric Acids; Animals; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anxiety; Anxiety Disorders; Anxiolytic Agents; Anxiolytics; Axon Terminals; Binding; Binding (Molecular Function); Brain; Butanoic acid, 4-amino-; Cerebral cortex; Cessation of smoking; Chronic; Cigarette; Common Rat Strains; D-Glucose; Data; Dependence, Nicotine; Depressed mood; Depression; Development; Dextrose; Disease; Disorder; Drugs; Encephalon; Encephalons; Ethanol dependence; Exclusion Criteria; Exhibits; Feeling; GABA; Gender; Gln; Glucose; Glutamates; Glutamine; History; Hour; Human; Human, General; Individual; Inhalators; Inhaler; L-Glutamate; L-Glutamine; Label; Lead; Link; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Medication; Menstrual cycle; Mental Depression; Methods; Molecular Interaction; Mood Disorders; Nerve Cells; Nerve Endings, Presynaptic; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neurons; Neurotransmitters; Nicotine; Nicotine Dependence; Nicotine Inhaler; Nicotine Replacement Therapy; Nicotrol Inhaler; Outcome; PBO; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Placebos; Presynaptic Terminals; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Q. Levoglutamide; Questionnaires; Rat; Rattus; Receptor Protein; Recording of previous events; Recycling; Reporting; Science of neurochemistry; Severities; Sex Characteristics; Sex Differences; Sham Treatment; Smoke; Smokeless Nicotine Inhaler; Smoker; Smoking; Synaptic Boutons; Synaptic Terminals; System; System, LOINC Axis 4; Testing; Time; Tobacco; Tobacco smoking; Tranquilizing Agents, Minor; Woman; Work; addiction; alcohol addiction; alcohol dependency; alcohol-dependent; antianxiety agent; base; cease smoking; craving; depressed; disease/disorder; drug/agent; ethanol addiction; ethanol dependency; ethanol-dependent; experience; falls; feelings; gamma-Aminobutyric Acid; gender difference; heavy metal Pb; heavy metal lead; insight; men; men's; neurochemistry; neuronal; neuropsychiatric; neuropsychiatry; neurotransmitter release; new approaches; nicotine addiction; nicotine replacement; novel approaches; novel strategies; novel strategy; oxidation; public health relevance; receptor; response; sadness; sex; sexual dimorphism (noncellular); sham therapy; smoking cessation; success",GABA Effects of Nicotine in Men and Women, This work will establish what changes in GABAergic neurons in the cerebral cortex are associated with nicotine and some of the subjective feelings that people experience with nicotine. The outcomes may help to explain why some of the newer drug-based smoking cessation approaches are effective and guide the development of new approaches. The results may also contribute to our understanding of why depressed people and patients with alcohol dependence have a greater likelihood of addiction to tobacco.,21785,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,368651,
7760552,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA021898-09,,NCI:371621;NICHD:148500;NIDA:801667;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HANOVER,UNITED STATES,PSYCHOLOGY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"GIBBONS, FREDERICK X;",7737567;,5R01DA021898,08/10/2001,12/31/2012,"0-11 years old; 12-20 years old; 21 year old; 21+ years old; AIDS Virus; AOD use; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adolescence; Adolescent; Adolescent Youth; Adopted; Adult; Adverse Late Effects; Affect; Affective Disorders; African American; Afro American; Afroamerican; Age; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Area; Attitude; Back; Behavior; Behavioral; Biological Factors; Biological Function; Biological Process; Black Populations; Black or African American; Buffers; Care Givers; Caregivers; Categories; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Causality; Characteristics; Chemical Class, Alcohol; Child; Child Youth; Childhood; Children (0-21); Cognition; Cognitive; Cognitive Discrimination; Communities; Crossing Over; Crossing Over, Genetic; Data; Dependence; Development; Discrimination; Discrimination (Psychology); Disinhibition; Dorsum; Drug usage; Effects, Longterm; Elements; Environment; Environmental Factor; Environmental Risk Factor; EtOH drinking; Ethnic group; Etiology; Exclusion; Expectancy; Exposure to; Factor, Biologic; Family; Family and Community Health Study; Family dynamics; Family member; Figs; Figs - dietary; Friends; Funding; Gender; Gene variant; Genes; Genetic; Genetic Crossing Over; Genetic Diversity; Genetic Polymorphism; Genetic Variation; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Habits; Health; Health behavior; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Individual; Individual Differences; Interview; Investigators; LAV-HTLV-III; Late Effects; Life; Long-Term Effects; Lymphadenopathy-Associated Virus; Measures; Mediating; Mental Health; Mental Hygiene; Modeling; Mood Disorders; Natural Products; Neighborhoods; Occidental; Outcome; Parenting; Parenting behavior; Parents; Participant; Pattern; Personality; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Process; Psyche structure; Psychological Health; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Retrospective Studies; Risk; Risk Behaviors; Risk Factors; Risk-Taking; Risky Behavior; Role; Sampling; Self-control as a personality trait; Sex Behavior; Sex Characteristics; Sex Differences; Sexual Activity; Sexual Behavior; Shapes; Siblings; Social Environment; Socialization; Socializations; Source; Stress; Substance Use Disorder; Substance abuse problem; T-Lymphotropic Virus Type III Infections, Human; Temperament; Testing; Time; Variation (Genetics); Virus-HIV; Youth; Youth 10-21; abuse of substances; adolescence (12-20); adolescent smoking; adolescent substance use; adult human (21+); adult youth; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic variant; at risk behavior; base; behavioral disinhibition; black American; children; critical period; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; early experience; emerging adult; emerging adulthood; environmental risk; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; falls; family influence; family structure/dynamics; gender difference; heuristics; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; intervention development; juvenile; juvenile human; mental; nonsister chromatid exchange; parent influence; parent monitoring; parental influence; parental monitoring; pediatric; peer; peer influence; physical conditioning; polymorphism; preadolescence; preteen; prospective; prototype; psychosocial; race discrimination; racial and ethnic; racial discrimination; racial/ethnic; risk perception; risky sexual behavior; self control; sex activity; sexual dimorphism (noncellular); social; social climate; social context; social role; socioenvironment; substance abuse; substance use; teenage; theories; therapy development; trait; treatment development; twenty-one year old; white race; willingness; young adult; youngster; youth substance use",Factors Influencing the Health Behavior of Young African American Adults,,21898,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,9,1321788,
7999209,R01,DA,5,,01/01/2010,12/31/2010,PA-05-067,5R01DA021905-03,,NIDA:413728;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"BROWN, SANDRA A;",1869436;,5R01DA021905,07/01/2008,12/31/2012,"12-20 years old; Active Follow-up; Addiction, Drug; Address; Adolescence; Adolescent; Adolescent Youth; Affect; Agreement; Behavior; Behavioral; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Clinical; Collaborations; Communities; Comorbidity; Conduct Disorder; DNA; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Deoxyribonucleic Acid; Dependence, Drug; Dependence, Substance; Development; Drug Addiction; Drug Dependency; Drug abuse; Elements; Family; Genetic; Genotype; Guidelines; Health; Individual; Intracellular Communication and Signaling; Investigators; Maps; Molecular; NIDA; National Institute of Drug Abuse; Neurobiology; Pattern; Phenotype; Plant Roots; Predisposition gene; Psychiatrist; Psychologist; Psychopathology; Qualifying; Research Personnel; Research Resources; Researchers; Resources; Role; Sample Size; Sampling; Siblings; Signal Transduction; Signal Transduction Systems; Signaling; Site; Substance Addiction; Susceptibility Gene; Technology; Testing; abnormal psychology; abuse of drugs; abuses drugs; adolescence (12-20); aged; anti social; antisocial; association test; biological signal transduction; clinical data repository; clinical data warehouse; cost; data repository; early onset; follow up assessment; follow-up; genetic association; genetic epidemiology; juvenile; juvenile human; lymphoblastoid cell line; multidisciplinary; neurobiological; predisposing gene; proband; relational database; root; sharing data; social role; teenage",Genetics of Adolescent Antisocial Drug Dependence,,21905,ZRG1,Special Emphasis Panel,,3,413728,
7998223,R01,DA,5,,01/01/2010,12/31/2010,PA-05-067,5R01DA021913-03,,NIDA:619631;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,AURORA,UNITED STATES,PSYCHIATRY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"HOPFER, CHRISTIAN J;",3031568;,5R01DA021913,07/01/2008,12/31/2012,"12-20 years old; Active Follow-up; Addiction, Drug; Address; Adolescence; Adolescent; Adolescent Youth; Affect; Agreement; Behavior; Behavioral; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Clinical; Collaborations; Communities; Comorbidity; Conduct Disorder; DNA; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Deoxyribonucleic Acid; Dependence, Drug; Dependence, Substance; Development; Drug Addiction; Drug Dependency; Drug abuse; Elements; Family; Genetic; Genotype; Guidelines; Health; Individual; Intracellular Communication and Signaling; Investigators; Maps; Molecular; NIDA; National Institute of Drug Abuse; Neurobiology; Pattern; Phenotype; Plant Roots; Predisposition gene; Psychiatrist; Psychologist; Psychopathology; Qualifying; Research Personnel; Research Resources; Researchers; Resources; Role; Sample Size; Sampling; Siblings; Signal Transduction; Signal Transduction Systems; Signaling; Site; Substance Addiction; Susceptibility Gene; Technology; Testing; abnormal psychology; abuse of drugs; abuses drugs; adolescence (12-20); aged; anti social; antisocial; association test; biological signal transduction; clinical data repository; clinical data warehouse; cost; data repository; early onset; follow up assessment; follow-up; genetic association; genetic epidemiology; juvenile; juvenile human; lymphoblastoid cell line; multidisciplinary; neurobiological; predisposing gene; proband; relational database; root; sharing data; social role; teenage",Genetics of Adolescent Antisocial Drug Dependence,,21913,ZRG1,Special Emphasis Panel,,3,619631,
7794861,R01,DA,5,,03/01/2010,02/28/2011,PAR-07-086,5R01DA022239-03,,NIDA:308732;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,AURORA,UNITED STATES,PSYCHIATRY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"NOVINS, DOUGLAS K;",2501995;,5R01DA022239,05/15/2008,02/28/2012,"AOD use; Alcohol or Other Drugs use; Alcohols; American Indian and Alaska Native; American Indian or Alaska Native; Case Study; Chemical Class, Alcohol; Communities; Data; Drug usage; Drugs; Evidence based practice; Funding Mechanisms; Health; Human Resources; Indigenous Population; Manpower; Medication; Methods; Native Americans; Native People; Native-Born; Pharmaceutic Preparations; Pharmaceutical Preparations; Phone; Prevalence; Prevention; Programs (PT); Programs [Publication Type]; Reporting; Research; Research Design; Special Population; Staging; Study Type; Study models; Substance abuse problem; Survey Instrument; Surveys; System; System, LOINC Axis 4; Telephone; Tribes; abuse of substances; case report; drug use; drug/agent; improved; insight; named group; personnel; programs; public health relevance; study design; substance abuse; substance use; treatment program",Evidence-Based Practices and Substance Abuse Treatment for Native Americans,,22239,ZRG1,Special Emphasis Panel,,3,308732,
7756674,R01,DA,5,,01/01/2010,12/31/2010,PA-07-119,5R01DA022291-02,,NIDA:625147;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,KINGSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,796475382,US,RI,028810811,UNIVERSITY OF RHODE ISLAND,"PROCHASKA, JAMES O;",8163221;,5R01DA022291,01/15/2009,12/31/2012,"Active Follow-up; Addiction, Drug; Address; After Care; After-Treatment; Aftercare; Alcohol abuse; Blue Cross; Cessation of Treatment; Cessation of smoking; Chemical Dependence; Collaborations; Combined Modality Therapy; Communication; Computers; Counseling; Dependence, Drug; Dependence, Nicotine; Drug Addiction; Drug Dependency; Drugs; Effectiveness; Health; Health Care Providers; Health Care Research; Health Personnel; Health Services; Health Services Evaluation; Health Services Research; Healthcare Providers; Healthcare Research; Healthcare Systems; Healthcare worker; Institutes; Intervention; Intervention Strategies; Investigators; Mediator; Mediator of Activation; Mediator of activation protein; Medical Care Research; Medication; Modeling; Motivation; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; NIDA; National Institute of Drug Abuse; Nicotine Dependence; Nicotine Replacement Therapy; Outcome; PROV; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Preparation; Prevention; Process; Provider; QOL; Quality of life; Randomized; Research; Research Personnel; Research Resources; Researchers; Resources; Rhode Island; Sampling; Services; Smoker; Smoking; Staging; Systems, Health Care; Treatment outcome; Withholding Treatment; Work; addiction; alcohol problem; base; behavior change; cease smoking; combination therapy; combined modality treatment; combined treatment; comparative; compare effectiveness; cost effective; cost effectiveness; drug/agent; ethanol abuse; ethnic minority; ethnic minority population; follow-up; hazardous alcohol use; health care personnel; health care service; health care worker; health provider; healthcare personnel; intervention design; interventional strategy; medical personnel; multimodality therapy; nicotine addiction; nicotine replacement; problem drinking; public health relevance; randomisation; randomization; randomly assigned; response; services research; smoking cessation; therapy design; treatment design; treatment effect; treatment provider; treatment strategy",Comparing Population Cessation Services with Emphasis on Unmotivated Smokers," Project Narrative If the treatment combining Motivation Enhancement, Reduction Counseling, Nicotine Replacement Therapy and Transtheoretical tailored interventions produces an increasing treatment trajectory, it will produce unprecedented impacts with unmotivated smokers specifically and population cessation generally. These recruitment and intervention strategies require limited resources from health care providers and could be readily disseminable to other health care systems for application with populations of smokers, especially unmotivated smokers who have been understudied and underserved.",22291,NIDA,Neuropharmacology Research Subcommittee,,2,625147,
7755368,R01,DA,5,,01/01/2010,12/31/2010,PA-07-114,5R01DA022366-03,,NIDA:475959;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ENSMINGER, MARGARET E.;",1897369;,5R01DA022366,03/15/2008,12/31/2011,"0-11 years old; 12-20 years old; 21+ years old; Active Follow-up; Address; Adolescence; Adult; Affect; African American; Afro American; Afroamerican; Age; Behavior; Behavioral; Black Populations; Black or African American; Causality; Chicago; Child; Child Youth; Childhood; Children (0-21); Communities; Complex; Crime; Criminal Justice; Data; Development; Disadvantaged; Drug abuse; Drug usage; Drugs; Etiology; Family; Female; Gender; Health; Human, Adult; Human, Child; Imprisonment; Individual; Interviewer; Justice, Criminal; Lead; Learning; Length of Life; Life; Life Cycle; Life Cycle Stages; Longevity; Mediating; Medication; Mental Health; Mental Hygiene; Mortality; Mortality Vital Statistics; Mothers; NIH RFA; Neighborhoods; Outcome; Pathway interactions; Pattern; Pb element; Personal Satisfaction; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Population Study; Preventive Intervention; Psychological Health; Records; Request for Applications; Research; Research Resources; Resources; Risk; Risk Factors; Role; Sampling; Science of Statistics; Social Functioning; Societies; Socio-economic status; Socioeconomic Status; Source; Staging; Statistics; Status, Socioeconomic; System; System, LOINC Axis 4; Time; Time Study; Unemployment; Victimization; Violence; Woman; abstracting; abuse of drugs; abuses drugs; adolescence (12-20); adult human (21+); base; black American; children; cohort; cost; criminal behavior; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; drug/agent; emerging adult; experience; first grade; follow-up; health economics; heavy metal Pb; heavy metal lead; incarceration; inner city; interest; intervention design; intervention program; jobless; joblessness; life course; life span; lifespan; low socioeconomic status; male; member; men; men's; out of work; pathway; pediatric; preventional intervention strategy; prospective; race discrimination; racial discrimination; social; social integration; social role; socioeconomic; socioeconomically; socioeconomics; statistics; teenage; therapy design; treatment design; unemployed; violent; violent behavior; well-being; youngster",Drug Abuse and Crime Across the Life Course in an African American Population,,22366,BGES,Behavioral Genetics and Epidemiology Study Section,,3,475959,
7759602,R01,DA,5,,02/01/2010,01/31/2011,,5R01DA022455-03,,NIDA:389133;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"ABI-DARGHAM, ANISSA ;",1905218;,5R01DA022455,09/01/2007,01/31/2012,"12-20 years old; 21+ years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Cocaine; Addiction, Drug; Addictive Behavior; Address; Adolescence; Adult; Affect; Age; Age-Years; Agonist; Agreement; Alcohol dependence; Alcohols; Amphetamines; Animals; Anxiety; Arts; Behavior; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-; Benzeneethanamine, alpha-methyl-, (S)-; Binding; Binding (Molecular Function); Bolus; Bolus Infusion; Brain; Brain region; CB1 Receptor; Cannabinoids; Cannabis; Categories; Chemical Class, Alcohol; Chemical Dependence; Chronic; Cigarette Smoker; Clinical; Cocaine; Cocaine Dependences; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Collaborations; Comorbidity; Companions; Complex; Corpus Striatum; Corpus striatum structure; D2 receptor; DA Neuron; DRD2; DRD2 Receptor; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dependence; Dependence, Cannabis; Dependence, Drug; Dependences, Cocaine; Depression; Dexamfetamine; Dexedrine; Dextroamphetamine; Disease; Disorder; Disturbance in cognition; Dopamine; Dopamine D2 Receptor; Dopamine neuron; Drug Addiction; Drug Dependency; Drug Psychoses; Drug-Induced Psychosis; Drugs; Dual Diagnosis; Dual Diagnosis, Psychiatric; Dual diagnosis (psychiatry); EC 2.1.1; Encephalon; Encephalons; Equilibrium; Ethanol dependence; Ethnic Origin; Ethnicity; Ethnicity aspects; Gender; Genetics, Other; Genotype; Grant; Habits; Hemp Plant; Human; Human, Adult; Human, General; Hydroxytyramine; Image; Impaired cognition; Knowledge; Lead; Man (Taxonomy); Man, Modern; Marijuana Dependence; Measurement; Measures; Mediating; Mediation; Medical; Medical Imaging, Positron Emission Tomography; Medication; Mental Depression; Methods; Methods and Techniques; Methods, Other; Methyltransferase; Modeling; Molecular Interaction; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Other Genetics; PET; PET Scan; PET imaging; PETSCAN; PETT; Partition Coefficient; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Positron Emission Tomography Scan; Positron-Emission Tomography; Process; Productivity; Property; Property, LOINC Axis 2; Proton Magnetic Resonance Spectroscopic Imaging; Psychiatry; Psychoses; Psychotic Disorders; Public Health; Raclopride; Rad.-PET; Receptor Protein; Receptor, Cannabinoid, CB1; Relative; Relative (related person); Reporting; Resolution; Rewards; Risk; Role; Scanning; Schizophrenia; Schizophrenic Disorders; Self-Administered; Severities; Striate Body; Striatum; Striatum, Ventral; Structure; Substance abuse problem; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Testing; Time; Transmission; Ventral Striatum; Withdrawal; abuse of substances; abused drugs; addiction; adolescence (12-20); adult human (21+); alcohol addiction; alcohol dependency; alcohol-dependent; balance; balance function; base; clinical data repository; clinical data warehouse; cognitive dysfunction; cognitive loss; cognitively impaired; cost; d-Amphetamine; data repository; dementia praecox; dextro-Amphetamine; disease/disorder; dopamine system; dopaminergic neuron; drinking; drug of abuse; drug/agent; drugs abused; drugs of abuse; ethanol addiction; ethanol dependency; ethanol-dependent; genetic risk factor; heavy metal Pb; heavy metal lead; human subject; imaging; inherited factor; innovate; innovation; innovative; methylase; neuronal; pathway; pre-clinical; preclinical; public health medicine (field); radiolabel; radiotracer; receptor; receptor binding; relational database; schizophrenic; social role; socioeconomic; socioeconomically; socioeconomics; striatal; substance abuse; teenage; transmethylase; transmission process",Imaging dopamine transmission in cannabis dependence,,22455,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,3,389133,
7750574,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA022460-03,,NIDA:350986;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,DALLAS,UNITED STATES,PSYCHIATRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"BROWN, E SHERWOOD ;",1866820;,5R01DA022460,02/15/2008,12/31/2012,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Accounting; Addiction, Cocaine; Adverse effects; Affective Disorders; Affective Psychosis, Bipolar; After Care; After-Treatment; Aftercare; Alcohol dependence; Alcohols; Algorithms; Analysis, Data; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Behavior; Behavior Therapy, Cognitive; Behavioral Therapy; Bipolar Disorder; Blinded; CDP Choline; CNS Diseases; CNS disorder; Caring; Central Nervous System Diseases; Central Nervous System Disorders; Chemical Class, Alcohol; Cidifos; Citicoline; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Cocaine-Related Disorders; Cognition; Cognitive; Cognitive Therapy; Complement; Complement Proteins; Conduct Clinical Trials; Controlled Clinical Trials; Cytidine 5'-(trihydrogen diphosphate), P'-(2-(trimethylammonio)ethyl) ester, inner salt; Cytidine 5'-Diphosphocholine; Cytidine Diphosphate Choline; Data; Data Analyses; Dependence, Substance; Dependences, Cocaine; Depressed mood; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Dropout; Drops; Drug Evaluation, Preclinical; Drug Metabolic Detoxication; Drug Screening; Drug Therapy; Drugs; Dual Diagnosis; Dual Diagnosis, Psychiatric; Dual diagnosis (psychiatry); Dysfunction; Emotional Depression; Enrollment; Ethanol dependence; Europe; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Frequencies (time pattern); Frequency; Functional disorder; Future; Guidelines; HAM-D; Hamilton Depression Scale; Hamilton Rating Scale for Depression; Literature; Measurement; Measures; Medical; Medication; Membrane; Memory; Mental disorders; Mental health disorders; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Mood Disorders; Moods; NIDA; National Institute of Drug Abuse; Neuropsychologic Tests; Neuropsychological Tests; Neuropsychologies; Neuropsychology; Opioid; Out-patients; Outcome; Outcome Measure; Outpatients; PBO; Patient Self-Report; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phosphatides; Phospholipids; Physiopathology; Placebo Control; Placebos; Population; Preclinical Drug Evaluation; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Psychiatrist; Psychosis, Manic-Depressive; Psychotherapy, Cognitive; Randomized; Reporting; Research; Safety; Screening Result; Self-Report; Sham Treatment; Substance Addiction; Substance Use Disorder; Substance-Related Disorders; Symptoms; Symptoms of depression; System; System, LOINC Axis 4; Therapy, Cognition; Treatment Side Effects; Unspecified Mental Disorder; Urinary System, Urine; Urine; Withdrawal Symptom; alcohol addiction; alcohol dependency; alcohol-dependent; base; bipolar affective disorder; cholinergic; clinical investigation; clinical significance; clinically significant; cocaine use; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; cognitive control; cognitive function; craving; depressed; depressive; depressive symptoms; detoxification; drug/agent; enroll; ethanol addiction; ethanol dependency; ethanol-dependent; executive control; executive function; experience; intervention design; inventory of depressive symptomatology; manic depressive disorder; manic depressive illness; meetings; membrane structure; mental illness; neuropsychologic; pathophysiology; placebo controlled study; placebo controlled trial; primary outcome; programs; psychological disorder; public health research; randomisation; randomization; randomly assigned; response; sadness; secondary outcome; sham therapy; side effect; therapy adverse effect; therapy design; treatment adverse effect; treatment design",Citicoline for Bipolar Disorder and Cocaine Dependence,,22460,NIDA,Neuropharmacology Research Subcommittee,,3,350986,
7772353,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA022495-02,,NIDA:288883;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"COSGROVE, KELLY P;D'SOUZA, DEEPAK CYRIL (contact);",6277496;6966444 (contact);,5R01DA022495,03/01/2009,01/31/2012,"2-Hydroxy-N,N,N-trimethylethanaminium; 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; Abstinence; Acute; Affinity; Age; Agonist; Anterior; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Applications Grants; Area; Attention; Autopsy; Binding; Binding (Molecular Function); Binding Sites; Brain; Brain imaging; Brain region; Carbon Monoxide; Cerebellum; Cerebral cortex; Cessation of smoking; Chemicals; Choline; Cholinergic Agonists, Nicotinic; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Chronic; Cigarette; Clinical; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Collection; Combining Site; Comorbidity; Corpus Striatum; Corpus striatum structure; Cotinine; Counseling; Data; Dependence, Nicotine; Diagnosis; Disturbance in cognition; Drug Therapy; Drugs; Dysfunction; Encephalon; Encephalons; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; FLR; Failure (biologic function); Functional disorder; Grant Proposals; Grants, Applications; HOSP; Hospitalization; Hour; Human; Human, General; Image; Impaired cognition; Individual; Inpatients; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Major Tranquilizers; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Single Photon Emission Computed Tomography; Medication; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods; Molecular Interaction; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neurons; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Agonists; Nicotinic Receptors; Non-smoker; Nuclear Magnetic Resonance Imaging; Occipital lobe; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiopathology; Play; Psychological reinforcement; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Race; Racial Group; Radionuclide Tomography, Single-Photon Emission-Computed; Reactive Site; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Regulation; Reinforcement; Reinforcement (Psychology); Relative; Relative (related person); Rewards; Role; SPECT; SPECT imaging; Schizophrenia; Schizophrenic Disorders; Scotine; Selective inattention; Short-Term Memory; Site; Smoke; Smoker; Smoking; Stocks, Racial; Striate Body; Striatum; Suggestion; Symptoms; System; System, LOINC Axis 4; Temporal Lobe; Testing; Thalamic structure; Thalamus; Tobacco; Tobacco smoke; Tobacco smoking; Tomography, Emission-Computed, Single-Photon; Tranquilizing Agents, Major; Urinary System, Urine; Urine; Withdrawal; Zeugmatography; addiction; base; brain visualization; cease smoking; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; comparison group; contingency management; dementia praecox; drug/agent; failure; imaging; in vivo; information processing; interest; necropsy; neuronal; nicotine addiction; nonsmoker; occipital cortex; parietal cortex; pathophysiology; performance tests; postmortem; preclinical study; public health relevance; receptor; receptor binding; receptor expression; response; schizophrenic; selective attention; sex; smoking cessation; social role; striatal; temporal cortex; temporal lobe/cortex; thalamic; uptake; working memory",Imaging Nicotinic Acetylcholine Receptors in Schizophrenia,,22495,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,288883,
7752806,R01,DA,5,,02/01/2010,01/31/2011,PA-07-114,5R01DA022967-03,,NIDA:579622;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LEXINGTON,UNITED STATES,SOCIAL SCIENCES,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"OSER, CARRIE BETH;",6269000;,5R01DA022967,04/01/2008,01/31/2013,"AIDS Virus; AOD use; Accident and Emergency department; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; African American; Afro American; Afroamerican; Alcohol or Other Drugs use; Alcohols; Applications Grants; Assay; Bioassay; Biologic Assays; Biological Assay; Black Populations; Black or African American; Care, Health; Chemical Class, Alcohol; Chlamydia; Communities; Criminal Justice; Data; Dependence; Development; Drug abuse; Drug abuser; Drug usage; Drug user; Drugs; Economics; Emergency Department; Emergency room; Enabling Factors; Epidemiology; Event; Factors, Enabling; Fear; Female; Female Health; Foundations; Fright; Future; Gender; General Population; General Public; Goals; Gonococcal Infection; Gonorrhea; Grant Proposals; Grants, Applications; HCV; HCV infection; HIV; HOSP; HTLV-III; Health; Health Care Providers; Health Care Utilization; Health Personnel; Health Planning; Health Policy; Health Services; Health Status; Healthcare; Healthcare Providers; Healthcare worker; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; High-Risk Sex; Hospitalization; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Imprisonment; Incidence; Individual; Inpatients; Intervention; Intervention Strategies; Interview; Jail; Justice, Criminal; Kentucky; Knowledge; LAV-HTLV-III; Level of Health; Life; Literature; Location; Lymphadenopathy-Associated Virus; Mediating; Medical; Medication; Mental Health; Mental Hygiene; Misuses drugs; Miyagawanella; Modeling; Multivariate Analyses; Multivariate Analysis; NANBH; NIH Program Announcements; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Participant; Patient Self-Report; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Physicians; Population; Prevalence; Preventive Intervention; Prison Inmates; Prisoner; Prisons; Problem drug user; Program Announcement; Psychological Health; Public Health; Race; Racial Group; Recruitment Activity; Reporting; Research; Risk Behaviors; Risky Behavior; STD; Sampling; Self-Report; Series; Seroprevalences; Services; Severities; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Stocks, Racial; Structure; Substance abuse problem; Supervision; Survey Instrument; Surveys; System; System, LOINC Axis 4; Time; Trust; Universities; Unprotected Sex; Unsafe Sex; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Woman; Women's Health; Work; abuse of drugs; abuse of substances; abuses drugs; alcohol research; at risk behavior; base; bedsonia; black American; correctional institution resident; criminal offender; criminal offending; drug use; drug/agent; ethanol research; experience; follow-up; health care personnel; health care policy; health care service; health care service utilization; health care worker; health disparities; health disparity; health provider; health services utilization; healthcare personnel; healthcare service utilization; healthcare utilization; hepatitis non A non B; hepatitis nonA nonB; incarceration; innovate; innovation; innovative; interventional strategy; jail inmate; longitudinal design; medical personnel; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; non-drug; offender; physical conditioning; preventional intervention strategy; probation; public health medicine (field); racism; recidivism; recruit; service utilization; substance abuse; substance use; time use; treatment provider; treatment utilization","African American Female Drug Users: HIV, Health Disparities, & Criminality",,22967,BSCH,Behavioral and Social Consequences of HIV/AIDS Study Section,,3,579622,
7761288,R01,DA,5,,02/01/2010,01/31/2011,PA-07-123,5R01DA023086-03,,NIDA:491512;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN FRANCISCO,UNITED STATES,,08,044875854,US,CA,94107,SCIENTIFIC ANALYSIS CORPORATION,"MURPHY, SHEIGLA BRIGHID;",1887818;,5R01DA023086,02/01/2008,01/31/2011,"7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Address; Affect; Age; Age Group Unspecified; Alcohols; Amphetamines; Animal Welfare; Anxiety Disorders; Area; Attention; Belief; Bibliography; CNS Depressants; CNS stimulant; Categories; Censuses; Central Nervous System Depressants; Central Nervous System Stimulants; Central Stimulants; Chemical Class, Alcohol; Cocaine; Country; Critiques; Data; Data Collection; Diazepam; Dimensions; Drug Combinations; Drug Prescribing; Drug Prescriptions; Drug Prospecting; Drug usage; Drug user; Drugs; Ecological impact; Elements; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Ethnic Origin; Ethnicity; Ethnicity aspects; Ethnography; Future; Gender; Grouping; IACUC; IRBs; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Internet; Interview; Investigation; Investigators; Literature; Marihuana; Medical; Medication; Methodology, Research; Methods; Methods and Techniques; Methods, Other; Models, Theoretic; Motivation; Nature; Obesity; Opiates; Pain; Painful; Participant; Perception; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prescriptions, Drug; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prospecting, Drug; Protocol; Protocols documentation; Public Health; Questionnaires; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; SAMHSA; Sampling; San Francisco; Schools; Self Medication; Sex Characteristics; Sex Differences; Sleep Disorders; Social Health Services; Source; Structure; Study Type; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Techniques; Testing; Theoretical model; Time; United States Substance Abuse and Mental Health Services Administration; Update; Validity and Reliability; Valium; Vertebrate Animals; Vertebrates; WWW; Woman; Work; abstracting; abused drugs; adiposity; adult youth; age group; base; behavioral health; club drug; college student; corpulence; corpulency; corpulentia; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; ethnographic; experience; expiration; flexibility; gender difference; groupings; human subject; human subject protection; informant; information gathering; instrument; men; men's; nonmedical use; obese; obese people; obese person; obese population; prescription drug abuse; programs; public health medicine (field); racial and ethnic; racial/ethnic; recruit; response; sexual dimorphism (noncellular); sleep problem; social; social role; study design; university student; vertebrata; web; world wide web; young adult",A Qualitative Study of Nonmedical Prescription Drug Use,,23086,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,3,491512,
7765583,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023132-03,,NIDA:370999;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOULDER,UNITED STATES,PSYCHOLOGY,02,007431505,US,CO,80309,UNIVERSITY OF COLORADO AT BOULDER,"WATKINS, LINDA ;",1873358;,5R01DA023132,02/01/2008,01/31/2013,"1-(5'-oxohexyl)-3-methyl-7-propylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-; Absence of pain sensation; Absence of sensibility to pain; Addiction, Opiate; Adverse effects; Affect; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animal Welfare; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Asthma; Astrocytes; Astrocytus; Astroglia; Ataxia; Ataxy; Behavior; Bibliography; Blood - brain barrier anatomy; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood-Brain Barrier; Body Weight decreased; Boots Brand of Naloxone Hydrochloride; Brain; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Bronchial Asthma; Cataloging; Catalogs; Circadian Rhythms; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coagulation Factor I; Coagulation Factor One; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Commit; Common Rat Strains; Complex; Contin, MS; Coordination Impairment; Country; Data; Dependence; Dependence, Opiate; Development; Diurnal Rhythm; Dizziness; Dose; Drug Kinetics; Drug usage; Drugs; Dyssynergia; Ecological impact; Economic Income; Economical Income; Editorial Comment; Editorial Comment (PT); Employee Strikes; Encephalon; Encephalons; Endo Brand of Naloxone Hydrochloride; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Experimental Designs; Exposure to; Factor I; Factor One; Feels no pain; Fibrinogen; Glia; Glial Cells; Goals; Grant; Hand; Hemato-Encephalic Barrier; Hortega cell; IACUC; IRBs; Impact, Environmental; Income; Infumorph; Institutional Animal Care and Use Committee; Institutional Review Boards; Intellectual Property; International; Investigation; Japan; Japanese; Japanese Population; Kadian; Knowledge; Kolliker's reticulum; Laboratories; Lamepro Brand of Naloxone Hydrochloride; Left; Literature; MSir; Mammals, Rats; Measures; Mediating; Medication; Medulla Spinalis; Microglia; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; Morphine Addiction; Morphine Dependence; NIH; Naloxone; Narcan; Narcanti; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; No sensitivity to pain; Non-neuronal cell; Nyctohemeral Rhythm; Opiate Addiction; Opioid; Opioid Receptor; Oramorph; Oramorph SR; Pain; Painful; Pattern; Pentobarbital Sodium; Pentobarbital, Monosodium Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Phase; Phrases (PT); Phrases [Publication Type]; Physiologic; Physiological; Play; Principal Investigator; Private Sector; Programs (PT); Programs [Publication Type]; Published Comment; Rat; Rattus; Receptors, Opiate; Regimen; Regulation; Relative; Relative (related person); Reporting; Research; Research Ethics Committees; Research Resources; Resources; Respiratory Depression; Rewards; Role; Roxanol; Safety; Salaries; Science of Statistics; Science of neurochemistry; Sedation procedure; Sleep; Spinal; Spinal Cord; Staging; Statex SR; Statistics; Stimulus; Strikes; Strikes, Employee; Substance Withdrawal Syndrome; Survey Instrument; Surveys; TXT; Testing; Text; Time; Treatment Side Effects; Twenty-Four Hour Rhythm; United Drug Brand of Naloxone Hydrochloride; United States; United States National Institutes of Health; Up-Regulation; Up-Regulation (Physiology); Upregulation; Ventilatory Depression; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Wages; Weight Loss; Weight Reduction; Withdrawal; Withdrawal Syndrome; abstracting; addiction; analgesia; base; body weight loss; cell type; circadian; circadian process; clinical investigation; clinical relevance; clinically relevant; cost; cytokine; daily biorhythm; diurnal variation; drug craving; drug use; drug/agent; experience; experiment; experimental research; experimental study; expiration; gitter cell; high risk; human subject; in vivo; inhibitor; inhibitor/antagonist; mesoglia; microglial cell; microgliocyte; milligram; nerve cement; neural; neurochemistry; neuronal; neuropathic pain; novel; opiate abuse; opioid abuse; opioid addiction; opioid dependence; painful neuropathy; perivascular glial cell; phrases; post stroke; poststroke; pre-clinical; preclinical; preclinical study; preference; prevent; preventing; programs; propentofylline; relating to nervous system; research study; response; sedation; side effect; social role; statistics; success; therapy adverse effect; treatment adverse effect; vertebrata; volunteer; wt-loss",Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions,,23132,CMBG,Cellular and Molecular Biology of Glia Study Section,,3,370999,
7741733,R01,DA,5,,12/01/2009,11/30/2010,PA-07-307,5R01DA023157-02,,NIDA:510274;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEWARK,UNITED STATES,SOCIAL SCIENCES,00,059007500,US,DE,19716,UNIVERSITY OF DELAWARE,"SURRATT, HILARY L;",6855134;,5R01DA023157,12/01/2008,11/30/2012,"1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine; 2',3'-Didehydro-2',3'-dideoxythmidine; 2',3'-Didehydro-3'-deoxythymidine; 2',3'-Dideoxy-3'-thiacytidine; 2'3' didehydrodeoxythymidine; 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 3'-Deoxy-2'-thymidinene; 3TC; 6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-; 9-(2-phosphonomethoxypropyl)adenine; 9-(2-phosphonylmethoxypropyl)adenine; 9-PMPA; 9-ene-Tetrahydrocannabinol; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS/HIV; AIDS/HIV problem; AZT; AZT (Antiviral); Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Adherence; Adherence (attribute); Analgesics, Narcotic; Anti-HIV Positivity; Anti-Retroviral Agents; Antiretroviral Agents; Area; Attitude; Azidothymidine; Benzodiazepine Compounds; Benzodiazepines; Bristol-Myers Squibb brand of efavirenz; Care, Health; Caring; Combivir; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communication; County; D4T; Delta-9-Tetrahydrocannabinol; Deterioration; Development; Didehydrodeoxythymidine; Dihydrohydroxycodeinone; Dimensions; Dronabinol; Drug Delivery; Drug Delivery Systems; Drug Prescribing; Drug Prescriptions; Drug Targeting; Drug Targetings; Drug abuser; Drug resistance; Drug resistant viral; Drug usage; Drug user; Drugs; Du Pont brand of efavirenz; EFV; Ecologic Monitoring; Ecological Monitoring; Economics; Editorial Comment; Editorial Comment (PT); Environmental Factor; Environmental Monitoring; Environmental Risk Factor; Exposure to; Family; Florida; Foundations; Fraud; Frequencies (time pattern); Frequency; Funding; Gilead brand of tenofovir disoproxil fumarate; Goals; Government Agencies; HIV; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV drug resistance; HIV drug resistant; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Health; Health Care Providers; Health Care Utilization; Health Personnel; Healthcare; Healthcare Providers; Healthcare Systems; Healthcare worker; High-Risk Sex; History; Homelessness; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Indigent; Individual; Industry; Injection of therapeutic agent; Injections; Internet; Intervention; Intervention Strategies; Interview; Investigators; Kaletra; LAV-HTLV-III; Lamivudine; Left; Legal; Literature; Location; Lopinavir/Ritonavir; Lymphadenopathy-Associated Virus; Marinol; Marketing; Medicaid; Medical; Medicare/Medicaid; Medication; Mental Health; Mental Hygiene; Mesylate, Nelfinavir; Methods; Misuses drugs; Modeling; Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-; Motivation; NIDA; Narcotic Analgesics; National Institute of Drug Abuse; Nature; Nelfinavir Monomethane Sulfonate; Newly Diagnosed; Opioid; Oxycodeinon; Oxycodone; Oxycodone SR; Oxycontin; PROV; Patients; Pattern; Percocet; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacies; Pharmacologic Substance; Pharmacological Substance; Pharmacy facility; Phase; Physicians' Offices; Pill; Policies; Prescriptions, Drug; Pressure; Pressure- physical agent; Prevention; Price; Problem drug user; Process; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Provider; Psychological Health; Public Health; Published Comment; Qualitative Research; RGM; RTV; Recording of previous events; Recruitment Activity; Regimen; Reporting; Reportings, Hospital Risk; Research; Research Personnel; Researchers; Risk Management; Risk Reporting, Hospital; Ritonavir; Roxicodone; Sampling; Site; Source; Stavudine; Substance abuse problem; Systems, Health Care; T-Lymphotropic Virus Type III Infections, Human; Tenofovir; Testing; Tetrahydrocannabinol; Thymidine, 2',3'-didehydro-3'-deoxy-; Thymidine, 3'-azido-3'-deoxy-; Time; Transmission; Treatment Protocols; Treatment Regimen; Treatment Schedule; Trizivir; United Drug brand of efavirenz; Unprotected Sex; Unsafe Sex; Viewpoint; Viewpoint (PT); Viread; Virus-HIV; Vulnerable Populations; WWW; Waiting Lists; Work; ZDV; Ziagen; Zidovudine; abacavir; abacavir sulfate; abuse of substances; anti-retroviral; antibody positive AIDS test; antigen positive AIDS test; antiretroviral; azidodeoxythymidine; base; beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine; delta(1)-THC; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; drug resistant; drug resistant virus; drug use; drug/agent; efavirenz; effective therapy; emtricitabine; environmental risk; environmental testing; experience; follow-up; health care personnel; health care service utilization; health care worker; health organization; health provider; health services utilization; healthcare personnel; healthcare service utilization; healthcare utilization; homeless; interventional strategy; medical personnel; norvir; pill (pharmacologic); prescription drug abuse; pressure; pricing; programs; public health medicine (field); public health relevance; recruit; resistance to Drug; resistance to HIV drug; resistant strain; resistant to Drug; resistant to HIV drug; seropositive (AIDS test); substance abuse; sustiva; theories; transmission process; treatment provider; treatment utilization; truvada; unhoused; viracept; web; world wide web; zerit",The Diversion of Antiretroviral Medications to Street Markets," A comprehensive understanding of the nature, motivations for, and mechanisms of ARV medication diversion is critical for funding and regulatory agencies, industry, public health organizations, and health care providers as they attempt to develop appropriate prevention, risk management, treatment, and policy initiatives. Most importantly, this study will inform interventions targeting the significant health consequences of ARV diversion and non-adherence by highly vulnerable populations.",23157,CIHB,Community Influences on Health Behavior,,2,510274,
7758710,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023170-04,,NIDA:552217;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WORCESTER,UNITED STATES,EMERGENCY MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"BOUDREAUX, EDWIN D;",7366422;,5R01DA023170,04/10/2008,01/31/2013,"21+ years old; AOD use; Abstinence; Active Follow-up; Acute; Address; Adoption; Adult; Affect; Affective; Alcohol or Other Drugs use; Behavior; Behavioral; Boxing; Buffers; Cardiac; Care, Health; Cell Phone; Cellular Phone; Cessation of smoking; Chronic; Clinical; Cognitive; Cox Models; Data; Data Collection; Decision Making; Dependence, Nicotine; Development; Drug Formulations; Employment Opportunities; Enrollment; Equation; Evaluation; Event; Fear; Formulation; Formulations, Drug; Frequencies (time pattern); Frequency; Fright; Funding Agency; Funding Source; Generalized Growth; Goals; Growth; HOSP; Health; Health behavior; Health behavior change; Healthcare; Hospitals; Hour; Human, Adult; Intention; Investigators; Lead; Left; Legal; Life; Maintenance; Maintenances; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Methods; Modeling; Models, Cox; Motivation; NIAAA; NIDA; NIH Program Announcements; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Nature; Nicotine Dependence; Outcome; Parents; Participant; Patients; Pattern; Pb element; Personal Satisfaction; Phone; Play; Population; Process; Program Announcement; Public Health; Recovery; Relapse; Relative; Relative (related person); Research; Research Personnel; Researchers; Role; SCHED; Sampling; Schedule; Sentinel; Sentinel Health Events; Severities; Smoke; Smoker; Smoking; Specific qualifier value; Specified; Staging; Structure; Survey Method; Survey Methodology; Symptoms; Telephone; Telephone, Cellular; Testing; Time; Tissue Growth; Tobacco Consumption; Tobacco use; Translating; Translatings; Uncertainty; adult human (21+); base; behavior change; cease smoking; density; doubt; enroll; experience; follow-up; heavy metal Pb; heavy metal lead; improved; interpersonal conflict; intervention design; language translation; nicotine addiction; novel; ontogeny; patient population; psychologic; psychological; public health medicine (field); public health relevance; respiratory; response; smoking cessation; smoking relapse; social role; substance use; theories; therapy design; treatment design; trend; well-being",The Sentinel Events Model: A Dynamic Model of Substance Use Cessation,"PUBLIC HEALTH RELEVANCE: The studies outlined herein have important implications for improving public health, because they will elucidate both cognitive and affective factors associated with decision making in the initiation and maintenance of substance cessation. In this revision, we expand the population focus of our analysis to patients with an acute respiratory illness. Respiratory illnesses, both acute and chronic in nature, are common comorbid medical conditions associated with tobacco use. The results will inform the development of new interventions designed to translate the teachable moment afforded by a healthcare encounter into lasting behavior change.",23170,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,4,552217,
7643206,R01,DA,5,,04/01/2010,03/31/2011,PA-07-070,5R01DA023190-03,,NIDA:591640;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PROVIDENCE,UNITED STATES,,01,069847804,US,RI,02906,"BUTLER HOSPITAL (PROVIDENCE, RI)","BROWN, RICHARD A;",1875760;,5R01DA023190,09/28/2007,03/31/2012,"Affect; After Care; After-Treatment; Aftercare; American Cancer Society; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Care, Health; Cessation of Treatment; Cessation of smoking; Clinical; Clinical Trials; Clinical Trials, Unspecified; Dependence, Nicotine; Depression; Diagnostic; Drug Therapy; Drugs; Emotional Depression; Enrollment; FLR; Failure (biologic function); Fluoxetin; Fluoxetine; Funding; Future; Healthcare; Knowledge; Major Depressive Disorder; Mediating; Medication; Mental Depression; Moods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Nicotine Dependence; Nicotine Skin Patch; Nicotine Withdrawal; Outcome; PBO; PTC2; PTCH2; PTCH2 protein, human; Participant; Patched 2; Patched Homolog 2; Patched Protein Homolog 2; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Placebo Control; Placebo Effect; Placebos; Prevalence; Primary Care; Primary Health Care; Primary Healthcare; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Psychiatric Diagnosis; Public Health; R01 Mechanism; R01 Program; RGM; RPG; Randomized; Randomized Clinical Trials; Regimen; Relative; Relative (related person); Research; Research Design; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Risk; Risk Factors; SSRI; Sampling; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Sequential Treatment; Sham Treatment; Smoke; Smoker; Smoking; Study Type; Symptoms of depression; Testing; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; Trials, Randomized Clinical; Withdrawal Symptom; Withholding Treatment; alternative treatment; cease smoking; cigarette smoking; clinical investigation; clinical practice; depressive; depressive symptoms; design; designing; double-blind placebo controlled trial; double-masked controlled study; double-masked controlled trial; drug/agent; enroll; expectancy effect; expectation effect; failure; human PTCH2 protein; improved; interest; major depression; meetings; negative mood; nicotine addiction; nicotine patch; nocebo; patched 2 protein, human; patched homolog 2 (Drosophila) protein, human; placebo response; positive mood; programs; public health medicine (field); randomisation; randomization; randomly assigned; serotonin reuptake inhibitor; sham therapy; smoke cigarette; smoking cessation; study design; time use",Sequential Use of Fluoxetine for Smokers with Elevated Depressive Symptoms,,23190,NIDA,Neuropharmacology Research Subcommittee,,3,591640,
7763160,R01,DA,5,,02/01/2010,01/31/2011,PA-07-119,5R01DA023191-03,,NIDA:636595;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,KINGSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,796475382,US,RI,028810811,UNIVERSITY OF RHODE ISLAND,"REDDING, COLLEEN A.;",8163231;,5R01DA023191,02/05/2008,01/31/2012,"Active Follow-up; Analysis, Data; Animal Welfare; Bibliography; Budgets; Cessation of smoking; Collaborations; Communication; Complex; Control Groups; Country; Data; Data Analyses; Dependence, Nicotine; Development; Ecological impact; Effectiveness; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Feedback; Foundations; Funding; Future; History; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Investigators; Lead; Leadership; Manuals; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Nicotine Dependence; Outcome; Paper; Participant; Pathway interactions; Pb element; Persons; Phase; Pilot Projects; Play; Population; Preparedness; Principal Investigator; Printing; Programs (PT); Programs [Publication Type]; Publications; Qualifying; R01 Mechanism; R01 Program; RPG; Randomized; Readiness; Recording of previous events; Reporting; Research; Research Ethics Committees; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Role; Running; Sampling; Scientific Publication; Series; Smoker; Smoking; Solid; Specific qualifier value; Specified; Staging; Surface; TXT; Testing; Text; Time; United States National Institutes of Health; Vertebrate Animals; Vertebrates; Work; abstracting; addiction; base; behavior change; cease smoking; cost; design; designing; dissemination research; experience; expiration; follow-up; heavy metal Pb; heavy metal lead; human subject; interest; interventional strategy; nicotine addiction; novel; pathway; pilot study; population based; premature; programs; randomisation; randomization; randomly assigned; response; smoking cessation; social role; vertebrata",Optimal TTM Tailoring for Population Cessation,,23191,NIDA,Neuropharmacology Research Subcommittee,,3,636595,
7758349,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA023206-03,,NIDA:259009;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PULLMAN,UNITED STATES,VETERINARY SCIENCES,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"DONG, YAN ;",8662369;,5R01DA023206,03/01/2008,12/31/2012,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Cocaine; Addictive Behavior; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anal; Anus; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biotinylation; Blotting, Western; Brain; Brain Diseases; Brain Disorders; CNS plasticity; CREB; CREB1; CREB1 gene; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Collection; Cornu Ammonis; Dependences, Cocaine; Drugs; Encephalon; Encephalon Diseases; Encephalons; Exposure to; Expression Profiling; Expression Signature; Figs; Figs - dietary; Foundations; Gene Transfer; Glutamates; Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Intervention; Intervention Strategies; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Knowledge; L-Glutamate; Laboratories; Lead; Learning; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane; Methods and Techniques; Methods, Other; Molecular; Molecular Fingerprinting; Molecular Profiling; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Nucleus Accumbens; Outcome; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Prefrontal Cortex; Preparation; Prevention; Procedures; Property; Property, LOINC Axis 2; Proteins; Public Health; Receptor Protein; Receptors, N-Methylaspartate; Research; Role; Saline; Saline Solution; Slice; Subcellular Process; Surface; Synapses; Synaptic; Techniques; Testing; Therapeutic; Time; Viral; Western Blotting; Western Blottings; Western Immunoblotting; Work; abstracting; abused drugs; addiction; amygdaloid nuclear complex; base; behavior test; behavioral test; clinical investigation; cocaine exposure; design; designing; drug of abuse; drug/agent; drugs abused; drugs of abuse; effective therapy; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hippocampal; in vivo; innovate; innovation; innovative; insight; interventional strategy; membrane structure; molecuar profile; molecular signature; neural; neural plasticity; neuroadaptation; neuronal; neuroplasticity; novel; patch clamp; prevent; preventing; protein blotting; public health medicine (field); receptor; relating to nervous system; research study; selective expression; selectively expressed; social role; theories; transcription factor; transfer of a gene; trial regimen; trial treatment",Cocaine-induced Adaptation in NMDA Receptors in Nucleus Accumbens,,23206,NMB,Neurobiology of Motivated Behavior Study Section,,3,259009,
7765604,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023210-03,,NIDA:389813;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SIEGEL, STEVEN J;",6409280;,5R01DA023210,02/01/2008,01/31/2013,"12-20 years old; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 21+ years old; Accounting; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Ag element; American; Ammon Horn; Animal Model; Animal Models and Related Studies; Animal Welfare; Animals; Arm; Award; Basic Research; Basic Science; Bibliography; Biochemical; Brain; CNS plasticity; Cell Death; Cell/Tissue, Immunohistochemistry; Cells; Chronic; Clinical Data; Cognitive; Cognitive deficits; Cornu Ammonis; Country; Coupled; Data; Development; Dose; Drug abuse; Drugs; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event-Related Potentials; Evoked Potentials; Exposure to; FVB Mouse; Future; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; IACUC; IHC; IRBs; Immunohistochemistry; Immunohistochemistry Staining Method; Impact, Environmental; Inbred C3H Mice; Inbred Strain; Incidence; Individual; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intoxication; Investigation; Investigators; Ketamine; Knowledge; Lead; Learning; Life; Literature; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Medication; Mental disorders; Mental health disorders; Methods; Metric; Mice; Mice, Inbred C3H; Modeling; Mouse, C3H; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; Nature; Nerve Degeneration; Nervous System, Brain; Neuron Degeneration; Neuronal Plasticity; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic; Physiological; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Receptor Mediated Signal Transduction; Receptor Signaling; Receptors, N-Methylaspartate; Regimen; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Saline; Saline Solution; Silver; Stress; Structure; Symptoms; Syndrome; Time; Unspecified Mental Disorder; Upper arm; Vertebrate Animals; Vertebrates; Work; abstracting; abuse of drugs; abused drugs; abuses drugs; adolescence (12-20); adult animal; adult human (21+); adult youth; base; brain behavior; cellular pathology; college; discount; drug of abuse; drug/agent; drugs abused; drugs of abuse; emerging adult; event related potential; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; high school; hippocampal; human subject; juvenile; juvenile human; ketamine abuse; mature animal; mental illness; model organism; necrocytosis; neural degeneration; neural plasticity; neurobehavioral; neurodegeneration; neuron toxicity; neuronal degeneration; neuronal toxicity; neuroplasticity; neurotoxic; neurotoxicity; phase 2 study; programs; psychological disorder; research study; social role; teenage; vertebrata; young adult",Long-term neurobehavioral effects of ketamine exposure in adolescent mice,,23210,NMB,Neurobiology of Motivated Behavior Study Section,,3,389813,
7760951,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023223-03,,NIDA:304784;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BUFFALO,UNITED STATES,PHARMACOLOGY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"MORRIS, MARILYN EMILY;",1967843;,5R01DA023223,04/01/2008,01/31/2012,"1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl-; 3,4 methylenedioxymethamphetamine; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Absolute ethanol; Acids; Administration, Oral; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Aminobutyric Acids; Animals; Blood Plasma; Blood Serum; Brain; Butanediols; Butylene Glycols; California; Central Nervous System; Cessation of life; Chemical Class, Alcohol; Clinical Research; Clinical Study; Cocaine; Coma; Comatose; Combined Modality Therapy; Common Rat Strains; D-Mannitol; Death; Dihydroxybutanes; Diuresis; Diuretics, Osmotic; Dose; Drug Administration, Oral; Drug Controls; Drug user; Drugs; Drugs, Recreational; ETOH; Ecstasy; Ecstasy - drug; Electrolytes; Encephalon; Encephalons; EtOH drinking; Ethanol; Extracellular Fluid; Forcible intercourse; GHN; Goals; Grain Alcohol; Grant; Growth Hormone; Growth Hormone 1; Health; Home; Home environment; Human; Human, General; Hydroxybutyrates; IV drip; In Situ; In Vitro; Instruction; Intermediary Metabolism; Internet; Intoxication; Intravenous Drip; Intravenous Infusion; Kidney; Liquid substance; MDMA; METBL; Mammals, Rats; Man (Taxonomy); Man, Modern; Mannitol; Medication; Metabolic Processes; Metabolism; Methods; Methylcarbinol; Methylenedioxymethamphetamine; Microdialysis; Mitochondria; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; N-Methyl-3,4-methylenedioxyamphetamine; Names; Nerve Transmitter Substances; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurotransmitters; Oral Administration; Osmitrol; Osmotic Diuretics; Overdose; Patients; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Pituitary Growth Hormone; Plasma; Production; Rape; Rat; Rattus; Recreational Drugs; Reflex; Reflex action; Renal clearance function; Reporting; Resectisol; Respiratory Depression; Reticuloendothelial System, Serum, Plasma; Route; STH; Serum; Serum, Plasma; Sleep; Soaps; Solvents; Somatotropin; Steroid Compound; Steroids; Survey Instrument; Surveys; Testing; Therapeutic Intervention; Therapeutic Uses; Time; Toxicokinetics; Urinary System, Kidney; Urinary System, Urine; Urine; Ventilatory Depression; WWW; abstracting; abused drugs; alcohol effect; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; assaulted sexually; attack, sexual; brain metabolism; brain tissue; butyrolactone; college student; combination therapy; combined modality treatment; combined treatment; drip infusion; drug of abuse; drug/agent; drugs abused; drugs of abuse; ecstasy; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; fluid; gamma hydroxybutyrate; hGHN; hypnotic; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; intraoral drug delivery; intravenous administration; liquid; mitochondrial; multimodality therapy; renal; renal clearance; sexual assault; somatotropic hormone; tissue preparation; treatment strategy; university student; uptake; vein infusion; volunteer; web; web site; world wide web","Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies",,23223,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,3,304784,
7794864,R01,DA,5,,03/01/2010,02/28/2011,PAS-07-115,5R01DA023368-04,,NIDA:632219;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CLAREMONT,UNITED STATES,NONE,26,076183789,US,CA,91711,CLAREMONT GRADUATE UNIVERSITY,"STACY, ALAN W;",7089095;,5R01DA023368,09/10/2008,02/28/2013,"21+ years old; AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Adult; Affect; Alcohols; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amnesia; Amnesia-Memory Loss; Area; Basic Research; Basic Science; Behavior; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Buffers; Characteristics; Chemical Class, Alcohol; Chronic; Clinical; Conscious; Consciousness; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Crystal Meth; Decision Theory; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyephedrine; Desoxyephedrine; Development; Discipline; Disease; Disease Frequency Surveys; Disorder; Drug abuse; Drug abuser; Drug usage; Drug user; Drugs; Evaluation; Evolution; Fostering; Future; Generalized Growth; Growth; HIV; HIV Prevention; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; Hand; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Individual; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; LAV-HTLV-III; Lead; Learning; Link; Lymphadenopathy-Associated Virus; Measurement; Measures; Mediation; Medication; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methamphetamine; Methods; Methylamphetamine; Misuses drugs; Modeling; Models, Theoretic; N-Methylamphetamine; Negotiating; Negotiation; Neurophysiology - biologic function; Neurosciences; Operating System; Operation; Operative Procedures; Operative Surgical Procedures; Pb element; Personality; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prevention; Prevention program; Primary Senile Degenerative Dementia; Problem drug user; Process; Property; Property, LOINC Axis 2; Prospective Studies; Research; Research Support; Risk; Risk Behaviors; Risky Behavior; Short-Term Memory; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Theoretical model; Time; Tissue Growth; Transmission; Virus-HIV; abuse of drugs; abused drugs; abuses drugs; addiction; adult human (21+); at risk behavior; behavior change; cognitive neuroscience; criminal offender; dementia of the Alzheimer type; disease/disorder; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; executive control; executive function; field study; hazard; heavy metal Pb; heavy metal lead; infancy; infantile; interventional strategy; memory process; neural function; neuropsychological; new approaches; novel approaches; novel strategies; novel strategy; offender; ontogeny; primary degenerative dementia; prospective; public health relevance; senile dementia of the Alzheimer type; sex; social cognition; surgery; theories; transmission process; working memory",Dual Processes in HIV Risk Behavior in Drug Abusers,,23368,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,4,632219,
7761290,R01,DA,5,,02/01/2010,01/31/2011,PA-07-123,5R01DA023577-03,,NIDA:625380;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,DAYTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,047814256,US,OH,45435,WRIGHT STATE UNIVERSITY,"CARLSON, ROBERT G;",2455215;,5R01DA023577,04/01/2008,01/31/2013,"AIDS Virus; Abuse, Heroin; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Age; Age Group Unspecified; Alcohols; Anxiety Disorders; Area; Boston; Characteristics; Chemical Class, Alcohol; City of Boston; Communities; Comorbidity; Complement; Complement Proteins; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; DSM-IV; DSM4; Dependence; Development; Diacetylmorphine; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Diamorphine; Dimensions; Disease; Disease Frequency Surveys; Disorder; Drug abuse; Drug abuser; Drug usage; Drugs; Early identification; Early treatment; Epidemiology; Epidemiology, Family Medical History; Ethnography; Family Medical History; Family history of; Frequencies (time pattern); Frequency; HIV; HTLV-III; Health Services; Healthcare Systems; Heroin; Heroin Abuse; Heroin Addiction; Heroin Dependence; Heroin Users; Heterogeneity; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Incidence; Individual; Internet; Intervention; Intervention Strategies; Interview; Interviewer; Knowledge; LAV-HTLV-III; Legal; Length; Life Cycle; Life Cycle Stages; Link; Lymphadenopathy-Associated Virus; Medical; Medication; Method LOINC Axis 6; Methodology; Methods; Misuses drugs; Modeling; Monitor; Moods; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Natural History; Ohio; Opioid; Pain; Painful; Participant; Pattern; Personality; Personality Disorders; Personality Traits; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Primary Care Physician; Problem drug user; Public Health; Recording of previous events; Recruitment Activity; Reporting; Research; Respondent; Risk; SCHED; Sampling; Schedule; Social Environment; Source; Staging; Structure; Substance abuse problem; Symptoms; System; System, LOINC Axis 4; Systems, Health Care; Time; Typology; United States; Users, Heroin; Virus-HIV; WWW; abuse of drugs; abuse of substances; abuses drugs; adult youth; age group; aged; anti social; antisocial; base; computerized; disease/disorder; drug use; drug/agent; ethnographic; ethnographic method; follow-up; health care service; innovate; innovation; innovative; insight; intervention development; interventional strategy; life course; opiate abuse; opioid abuse; opioid misuse; person centered; prescription drug abuse; public health medicine (field); public health relevance; recruit; response; social climate; social context; socioenvironment; substance abuse; theories; therapy development; treatment development; trend; web; working group; world wide web; young adult",Opioid Use Trajectories and HIV Risk among Young Adults in Ohio,,23577,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,3,625380,
7765579,R01,DA,5,,02/01/2010,01/31/2011,PA-07-282,5R01DA023593-03,,NIDA:256621;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,COLUMBIA,UNITED STATES,PHARMACOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"SWEITZER, SARAH M;",6069357;,5R01DA023593,04/01/2008,01/31/2012,"(17Beta)-17-hydroxyandrost-4-en-3-one; 0-11 years old; 17-beta-Hydroxy-4-Androsten-3-one; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 21+ years old; 4'-Nitro-3'-trifluoromethylisobutyranilide; Absence of pain sensation; Absence of sensibility to pain; Acute; Adult; Age; Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide; Androgen Receptor; Androst-4-en-17beta-ol-3-one; Animals; Assay; Basic Research; Basic Science; Behavior; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Cell/Tissue, Immunohistochemistry; Change of Life; Child; Child Youth; Childhood; Children (0-21); Circumcision; Climacteric; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Coupled; Delta4-androsten-17beta-ol-3-one; Development; Disease; Disorder; Distress; Down-Regulation; Down-Regulation (Physiology); Down-Regulation, Receptor; Downregulation; EDN1; ELISA; ET-1; ET-1 (Endothelin-1); Effects, Longterm; Endorphins; Endothelial Cells; Endothelin; Endothelin B Receptor; Endothelin Type 1; Endothelin-1; Endothelium-Derived Vasoconstrictor Factors; Enzyme-Linked Immunosorbent Assay; Epidermis; Esthesia; Event; Exposure to; Extremities; FLUT; Feedback; Feels no pain; Flutamide; Foundations; Future; Goals; HOSP; Heating; History; Hospitals; Hour; Human; Human, Adult; Human, Child; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Infant; Injury; Ion Channels, Sodium; Life; Limb structure; Limbs; Long-Term Effects; Male Circumcision; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Modeling; Molecular Interaction; NRVS-SYS; Neonatal; Nervous System; Nervous system structure; Neurologic Body System; Neurologic Organ System; Niftolid; Niftolide; No sensitivity to pain; Nociception; Nociceptors; Non-Trunk; Opioid Receptor; Pain; Painful; Pathway interactions; Peptides; Publishing; Rat; Rattus; Receptor Down-Regulation; Receptor Protein; Receptor Signaling; Receptor, Endothelin B; Receptors, Opiate; Recording of previous events; Regulation; Rodent; Rodentia; Rodentias; Role; Sensation; Series; Signal Pathway; Site; Skin; Skin Tissue; Sodium Channel; Stimulus; Testosterone; Therapeutic Testosterone; Time; Tissues; Touch; Touch sensation; Trans-Testosterone; V (voltage); Work; abstracting; adult human (21+); analgesia; animal pain; children; design; designing; disease/disorder; early experience; experience; infancy; infantile; inflammatory pain; intervention development; keratinocyte; male; new therapeutic target; nociceptive; pathway; patient population; pediatric; postnatal; premature; prevent; preventing; receptor; receptor expression; response; social role; spontaneous pain; subcutaneous; therapeutic development; therapy development; treatment development; voltage; youngster",Developmental regulation of endothelin pain,,23593,SAT,"Surgery, Anesthesiology and Trauma Study Section",,3,256621,
7765618,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023597-03,,NIDA:375210;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"KOOB, GEORGE F;",1881505;,5R01DA023597,04/05/2008,01/31/2013,"ACTH-Releasing Factor; Acute; Addiction, Drug; Agonist; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Animals; Anxiety; Biochemical; Biological; Brain; CRF-41; CRH; Causality; Cause of Death; Chemical Dependence; Common Rat Strains; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Dependence; Dependence, Drug; Dependence, Nicotine; Development; Drug Addiction; Drug Dependency; Drugs; Encephalon; Encephalons; Environment; Etiology; Future; Individual Differences; Intake; Intravenous; Lead; Mammals, Rats; Mediating; Medication; Microinjections; Modeling; Motivation; Nervous System, Brain; Neurobiology; Neurochemistry; Neuropeptide Tyrosine; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Procedures; Psychological reinforcement; Public Health; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rat; Rattus; Reinforcement; Reinforcement (Psychology); Rewards; Science of neurochemistry; Self Administration; Site; Smoke; Stress; System; System, LOINC Axis 4; Testing; Tobacco Consumption; Tobacco smoking; Tobacco use; United States; abstracting; amygdaloid nuclear complex; basal forebrain; base; corticotropin releasing hormone; deprivation; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug/agent; heavy metal Pb; heavy metal lead; heuristics; innovate; innovation; innovative; insight; intervention development; model organism; neurobiological; neurobiological mechanism; neurochemistry; neuropeptide Y; nicotine addiction; public health medicine (field); response; therapy development; translational study; treatment development",Central mechanisms of nicotine reinforcement and dependence,,23597,NMB,Neurobiology of Motivated Behavior Study Section,,3,375210,
7771707,R01,DA,5,,02/01/2010,01/31/2011,PA-07-275,5R01DA023877-03,,NIDA:704696;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,FAMILY MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"STRATHDEE, STEFFANIE A;",3108145;,5R01DA023877,02/01/2008,01/31/2013,"0-11 years old; 21+ years old; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AOD use; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Adult; Age; Alcohol or Other Drugs use; Anal Sex; Animal Welfare; Anti-HIV Positivity; Application Context; Arm; Articulation; Attitude; Bacterial Vaginosis; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bibliography; Birth Place; Budgets; California; Characteristics; Child; Child Youth; Children (0-21); Chlamydia; Cities; Client; Clinic; Communities; Conditioning Therapy; Condom; Condoms, Unspecified; Congenital Syphilis; Consult; Consumption; Country; Data Collection; Disease due to Trichomonadidae; Drug usage; Drugs; Ecological impact; Education; Educational aspects; Emotional Depression; Environment; Environmental Impact; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Equipment; Ethics Committees, Research; Expectancy; Female; Feminine; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Foundations; General Population; General Public; Genital System, Female, Vagina; Goals; Gonococcal Infection; Gonorrhea; Government; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV/STD; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; Herpes Zoster; Herpes zoster disease; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Hydrogen Oxide; Hygiene; IACUC; IRBs; Impact, Environmental; Incentives; Infant Food; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Intervention Studies; Investigators; Joints; Knowledge; LAV-HTLV-III; Laboratories; Life Style Modification; Light; Lymphadenopathy-Associated Virus; Maps; Marketing; Medication; Methods; Mexican; Mexico; Miyagawanella; Modeling; Needle Sharing; Needle-Exchange Programs; Needles; Needlesharing; Outcome; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Pilot Projects; Play; Population; Prevalence; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Publishing; Randomized; Recommendation; Recruitment Activity; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Risk; Risk Reduction; Role; Route; SIS; SUBGP; Secure; Self Efficacy; Sex Behavior; Sex Education; Sex, Anal; Sexual Activity; Sexual Behavior; Shares syringes; Shingles; Shipping; Ships; Side; Sister; Site; Soaps; Source; Specimen; Subgroup; Suggestion; Symptoms of depression; Syphilis; Syphilis, Congenital; Syringe Sharing; Syringe-Exchange Programs; Syringes; Testing; Time; Toy; Translating; Translatings; Trichomonas Infections; Trichomonosis; Upper arm; Vagina; Vaginal; Vaginitis, Bacterial; Vaginitis, Nonspecific; Vertebrate Animals; Vertebrates; Virus-HIV; Visit; Water; Woman; Work; Zona; Zoster; abstracting; adult human (21+); aged; antibody positive AIDS test; antigen positive AIDS test; baby food; base; bedsonia; behavior intervention; behavioral intervention; children; condoms; contextual factors; cost; depressive; depressive symptoms; design; designing; drug use; drug/agent; efficacy testing; experience; expiration; family structure; fluorescent dye/probe; follow-up; great pox; group intervention; herpes zona; high risk; high risk behavior; human subject; improved; incentive; inducement; intervention effect; interventional strategy; intimate partner violence; language translation; male; meetings; motivational enhancement therapy; motivational interview; needle exchange; peer; pilot study; pleasure; policy implication; primary outcome; programs; randomisation; randomization; randomly assigned; recruit; response; safer sex; self esteem; seropositive (AIDS test); sex; sex activity; social; social role; substance use; trafficking; trichomoniasis; vertebrata; voucher; youngster",Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US Border,,23877,ZRG1,Special Emphasis Panel,,3,704696,
7749973,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA023905-03,,NIDA:414612;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,NONE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"LAW, PING-YEE ;",1875199;,5R01DA023905,04/01/2008,01/31/2013,"Acute; Adeno-Associated Viruses; Adverse drug effect; Adverse effects; Affect; Agonist; Alkaloids; Amino Acid Sequence Homology; Amino Acids; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Area; Assay; Bioassay; Biologic Assays; Biological Assay; Boots Brand of Naloxone Hydrochloride; Brain; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; Cell Membrane Lipids; Cell model; Cellular model; Central gray substance of midbrain; Chimera; Chimera organism; Chronic; Complement; Complement Proteins; Complementary DNA; Constipation; Contin, MS; DNA, Complementary; Data; Dependence; Dependovirus; Development; Docking; Dorsal Horn of the Spinal Cord; Drug Side Effects; Drug usage; Drugs; Du Pont Brand of Naltrexone Hydrochloride; Electroporation; Elements; Encephalon; Encephalons; Endo Brand of Naloxone Hydrochloride; Endogenous Opiates; Engineering; Engineerings; Environment; Exhibits; Gene Delivery; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generations; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Genetics-Mutagenesis; Goals; In Vitro; Infection; Infumorph; Injection of therapeutic agent; Injections; Intervention, Genetic; Intracellular Second Messengers; Intrathecal Injections; Investigators; Itching; Kadian; Knock-in; Knock-in Mouse; Lamepro Brand of Naloxone Hydrochloride; Lamepro Brand of Naltrexone Hydrochloride; Ligands; Lipids; MSir; Mammals, Mice; Medical; Medication; Medulla Spinalis; Membrane Lipids; Mesencephalic Central Gray; Methods; Mice; Mice, Mutant Strains; Midbrain Central Gray; Modeling; Molecular; Molecular Biology, Gene Therapy; Molecular Biology, Mutagenesis; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; Murine; Mus; Mutagenesis; Mutant Strains Mice; Mutate; Mutation; Nalorex; Naloxone; Naltrexone; Narcan; Narcanti; Narcotic Antagonists; Nature; Nausea; Nemexin; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nociception; Opiate Antagonist; Opioid; Opioid Analgesics; Opioid Antagonists; Opioid Receptor; Oramorph; Oramorph SR; Orphan Brand of Naltrexone Hydrochloride; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pathway interactions; Periaqueductal Gray; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physicians; Property; Property, LOINC Axis 2; Pruritic Disorder; Pruritis; Pruritus; ReVia; Receptor Activation; Receptor Gene; Receptor Protein; Receptors, Opiate; Research Personnel; Researchers; Respiratory Depression; Rodent Model; Roxanol; Schering-Plough Brand of Naltrexone Hydrochloride; Second Messenger Systems; Second Messengers; Sedation procedure; Sequence Homology; Sequence Homology, Amino Acid; Sequence Homology, Protein; Site; Spinal Cord; Spinal cord posterior horn; Statex SR; Structure; TM Domain; Testing; Therapeutic Agents; Therapy, DNA; Transmembrane Domain; Transmembrane Region; Treatment Side Effects; United Drug Brand of Naloxone Hydrochloride; United Drug Brand of Naltrexone Hydrochloride; Ventilatory Depression; Virus; Viruses, General; Wild Type Mouse; abstracting; addiction; adeno associated virus group; aminoacid; analgesia; annulus of the aqueduct; base; cDNA; chronic pain; chronic painful condition; design; designing; dorsal horn; drug development; drug use; drug/agent; endogenous opioid; engineering design; extracellular; gene therapy; genetic therapy; genome mutation; homology (molecular); in vitro Assay; in vivo; midbrain central gray substance; mouse mutant; mutant; neuronal; nociceptive; pathway; periaqueductal gray matter; receptor; receptor binding; response; second messenger; sedation; side effect; social stigma; stigma; success; therapy adverse effect; transfer of a gene; treatment adverse effect",Engineered Opioid Receptors as Therapeutic Agents for Pain Control,,23905,ZRG1,Special Emphasis Panel,,3,414612,
7759559,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA024022-02,,NIDA:333011;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"ZHANG, YAN ;",8428643;,5R01DA024022,02/01/2009,01/31/2014,"Addiction, Drug; Addiction, Opiate; Adverse effects; Affinity; Agonist; Alcoholism; Amino Acids; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Assay; Attention; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Bovine Species; Bristol-Myers Squibb Brand of Naltrexone Hydrochloride; CNS Diseases; CNS disorder; Cattle; Central Nervous System Diseases; Central Nervous System Disorders; Chemical Dependence; Chemical Structure; Chemicals; Chronic; Clinical; Combining Site; Constipation; Dependence; Dependence, Drug; Dependence, Opiate; Development; Diacetylmorphine; Diamorphine; Disease; Disorder; Docking; Drug Addiction; Drug Dependency; Drug abuse; Du Pont Brand of Naltrexone Hydrochloride; Evaluation; Gambling; Gamblings; Goals; Heroin; Homology Modeling; In Vitro; Knowledge; Lamepro Brand of Naltrexone Hydrochloride; Lead; Ligands; Mammals, Mice; Medical; Membrane; Mice; Modeling; Models, Molecular; Molecular; Molecular Interaction; Molecular Models; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)-; Murine; Mus; Mutagenesis, Site-Directed; Mutate; Nalorex; Naltrexone; Nemexin; Nucleic Acid Biochemistry, Molecular Modeling; Operation; Operative Procedures; Operative Surgical Procedures; Opiate Addiction; Opiates; Opioid; Opioid Analgesics; Opioid Receptor; Opioid Receptor Binding; Orphan Brand of Naltrexone Hydrochloride; Pain; Painful; Pb element; Peptides; Physical Dependence; Programs (PT); Programs [Publication Type]; Protein/Amino Acid Biochemistry, Molecular Modeling; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; ReVia; Reactive Site; Receptor Protein; Receptors, Opiate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, kappa; Receptors, mu; Relapse; Research; Respiratory Depression; Rhodopsin; Roentgen Rays; Route; Schering-Plough Brand of Naltrexone Hydrochloride; Screening procedure; Series; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Societies; Staging; Structure; Structure-Activity Relationship; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Time; Treatment Side Effects; United Drug Brand of Naltrexone Hydrochloride; Urinary Retention; Ventilatory Depression; Visual Purple; X-Radiation; X-Rays; Xrays; abuse of drugs; abuses drugs; addiction; aminoacid; analgesia; aqueous; base; behavior test; behavioral test; bovid; bovine; chemical structure function; chemical synthesis; clinical applicability; clinical application; cow; design; designing; disease/disorder; extracellular; heavy metal Pb; heavy metal lead; in vivo; membrane structure; molecular modeling; next generation; novel; opiate abuse; opioid abuse; opioid addiction; opioid dependence; programs; public health relevance; radioligand; receptor; receptor structure function; screening; screenings; side effect; structure function relationship; surgery; therapy adverse effect; tool; treatment adverse effect",Non-peptide Mu Opioid Receptor Selective Antagonists,,24022,ZRG1,Special Emphasis Panel,,2,333011,
7766956,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA024030-02,,NIDA:249480;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,NEUROLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"GLASS, MICHAEL J;",7371092;,5R01DA024030,03/01/2009,01/31/2014,"AMPA Receptors; AMPA receptor, GluR2 subunit; Acute; Addiction, Opiate; Addictive Behavior; Address; Affect; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Arts; Attenuated; Behavior; Behavioral; Behavioral Model; Bilateral; Boots Brand of Naloxone Hydrochloride; Brain region; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; CNS plasticity; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Chronic; Complex; Contin, MS; Cues; Dendrites; Dendritic Spines; Dependence; Dependence, Opiate; Development; Dose; Drug Exposure; Drug usage; Endo Brand of Naloxone Hydrochloride; Gene Deletion; Genes; Genetic; GluR2 protein; GluR2 receptor; GluR2 subunit AMPA receptor; Glutamate Receptor; Goals; Infumorph; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Intracellular Communication and Signaling; K01 Award; K01 Mechanism; K01 Program; Kadian; Knock-out; Knockout; Knowledge; Lamepro Brand of Naloxone Hydrochloride; Learning; MSir; Mammals, Mice; Mediating; Memory; Mentored Research Scientist Development Award; Mentored Training Award; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Microinjections; Modeling; Molecular; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Morphine; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NR1; NR1 gene; Naloxone; Narcan; Narcanti; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurobiology; Neurocyte; Neuronal Plasticity; Neurons; Nucleus; Opiate Addiction; Opioid; Oramorph; Oramorph SR; Pathway interactions; Physiologic; Physiological; Play; Process; Property; Property, LOINC Axis 2; Public Health; Receptor Protein; Receptors, AMPA; Receptors, N-Methylaspartate; Receptors, Opioid, mu; Receptors, mu; Research Scientist Development Award; Role; Roxanol; Self Administration; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Source; Statex SR; Symptoms; Synapses; Synaptic; Techniques; Technology; Testing; United Drug Brand of Naloxone Hydrochloride; Withdrawal; addiction; adult animal; amygdaloid nuclear complex; biological signal transduction; brain pathway; clinical efficacy; dendrite spine; drug use; gene deletion mutation; interventional strategy; mature animal; neural; neural plasticity; neurobiological; neurogenetics; neuronal; neuroplasticity; novel; opioid addiction; opioid dependence; opioid withdrawal; pathway; postsynaptic; prevent; preventing; psychologic; psychological; public health medicine (field); receptor; relating to nervous system; social role; trafficking","GLUTAMATE RECEPTORS AND OPIOID DEPENDENCE: MOLECULES, CIRCUITS AND BEHAVIOR",,24030,NMB,Neurobiology of Motivated Behavior Study Section,,2,249480,
7745449,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA024039-03,,NIDA:361929;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ATLANTA,UNITED STATES,BIOLOGY,05,837322494,US,GA,303023999,GEORGIA STATE UNIVERSITY,"BARO, DEBORAH JEAN;",8478690;,5R01DA024039,01/05/2008,11/30/2012,"3'5'-cyclic ester of AMP; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); American; Animal Welfare; Antimorphic mutation; Associative Learning; Bibliography; Binding; Binding (Molecular Function); Biochemical; CRE Binding Protein; CREB; CREB Protein; CREB1; CREB1 gene; Cell Communication and Signaling; Cell Signaling; Characteristics; Chronic; Cocaine; Conditioning, Classical; Conditionings, Classical; Confocal Microscopy; Cost of Illness; Country; Crustacea; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic AMP-Responsive DNA-Binding Protein; D1 receptor; D2 receptor; DNA Molecular Biology; DRD2; DRD2 Receptor; Disease Costs; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dopamine; Dopamine D1 Receptor; Dopamine D2 Receptor; Dose; Drug abuse; Drugs; Ecological impact; Electrophysiology; Electrophysiology (science); Environment; Environmental Impact; Equipment; Ethics Committees, Research; Global Change; Hand; Hour; Hydroxytyramine; IACUC; IRBs; Imagery; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Ions; K element; Kv4 channel; Lead; Learning; Life; Measures; Mediating; Medication; Membrane; Membrane Channels; Memory; Methods and Techniques; Methods, Other; Microscopy, Confocal; Modeling; Modification; Molecular; Molecular Biology; Molecular Interaction; Names; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; PKA; Pavlovian conditioning; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Potassium; Principal Investigator; Prize; Process; Programs (PT); Programs [Publication Type]; Protein Kinase A; Protein Phosphorylation; Reporting; Research; Research Ethics Committees; Research Priority; Research Resources; Resources; Rewards; Sickness Cost; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Synapses; Synaptic; Techniques; Testing; Transcript; Vertebrate Animals; Vertebrates; Visualization; abstracting; abuse of drugs; abuses drugs; addiction; adenosine 3'5' monophosphate; biological signal transduction; cAMP; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; cAMP-Dependent Protein Kinases; classical conditioning; cocaine use; density; drug/agent; expiration; heavy metal Pb; heavy metal lead; human subject; membrane structure; neuronal; prevent; preventing; programs; response; reuptake; tool; transcription factor; vertebrata",Mechanisms underlying opposing neuronal responses to brief vs. prolonged dopamine,,24039,SMI,Sensorimotor Integration Study Section,,3,361929,
7755367,R01,DA,5,,01/01/2010,12/31/2010,PA-07-090,5R01DA024578-03,,NIDA:519045;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MILWAUKEE,UNITED STATES,PSYCHIATRY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"DICKSON-GOMEZ, JULIA B;",6862415;,5R01DA024578,03/15/2008,12/31/2011,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Area; Attention; Characteristics; Cities; City Planning; Communities; Connecticut; Development; Disease; Disorder; Drug usage; Drug user; Drugs; Economics; Ensure; Environment; Ethnic Origin; Ethnicity; Ethnicity aspects; Evaluation; Family; Gender; General Population; General Public; HIV; HIV Infections; HIV Prevention; HIV diagnosis; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Health Benefit; Health Status; History; Homelessness; Housing; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Injection of therapeutic agent; Injections; Interview; Investigators; LAV-HTLV-III; Laws; Legal; Level of Health; Location; Longitudinal Surveys; Low income; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Maps; Measures; Mediating; Medication; Mental Health; Mental Hygiene; Modeling; Movement; Neighborhoods; PROV; Participant; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Philosophy; Plannings, City; Plant Roots; Policies; Preventive Intervention; Programs (PT); Programs [Publication Type]; Provider; Psychological Health; R01 Mechanism; R01 Program; RPG; Recommendation; Recording of previous events; Recruitment Activity; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Sample Size; Sampling; Services; Shelter facility; Social Service; Social Welfare; Social Work; Social work (field); Substance abuse problem; Survey Instrument; Surveys; Surveys, Longitudinal; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Variant; Variation; Violence; Virus-HIV; abuse of substances; at risk behavior; body movement; cohort; convict; data modeling; disease/disorder; drug use; drug/agent; federal policy; high risk; homeless; housing instability; improved; informant; instably housed; instrument; intervention development; non-drug; preventional intervention strategy; programs; recruit; residence; response; root; sex; sex risk; shelter; shelter-housing; social; substance abuse; substance abuser; suburb; supported housing; supportive housing; therapy development; treatment development; unhoused; unstable housing; unstably housed; violent; violent behavior; welfare","Drug Use, Housing Access, Stability and HIV Risk among Low-Income Urban Residents",,24578,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,3,519045,
7756626,R01,DA,5,,02/01/2010,01/31/2011,PAS-07-115,5R01DA024579-03,,NIDA:641781;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEWARK,UNITED STATES,SOCIAL SCIENCES,00,059007500,US,DE,19716,UNIVERSITY OF DELAWARE,"KURTZ, STEVEN P;",7710480;,5R01DA024579,04/01/2008,01/31/2013,"21+ years old; AIDS; AIDS Virus; AIDS prevention; AIDS/HIV prevention; AOD use; Achievement; Achievement Attainment; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Adult; Alcohol or Other Drugs use; Area; Awareness; Awarenesses; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Caring; Characteristics; Cities; Clinical Trial Overviews; Communities; Conditioning Therapy; Coping Behavior; Counseling; Data Pooling; Data Poolings; Depression; Development; Drug usage; Economics; Effectiveness; Effectiveness of Interventions; Environment; Esthesia; Ethnic Origin; Ethnicity; Ethnicity aspects; Exercise; Exercise, Physical; Family; Florida; Funding; Gays; Goals; Group Processes; HIV; HIV Infections; HIV Prevention; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Health behavior; History; Home; Home environment; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Immunologic Deficiency Syndrome, Acquired; Incidence; Individual; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Intervention Studies; Investigators; LAV-HTLV-III; Life; Life Style Modification; Link; Literature; Living Wills; Lymphadenopathy-Associated Virus; Measures; Mediating; Mental Depression; Mental Health; Mental Hygiene; Meta-Analyses; Meta-Analysis; Minority; Modeling; NIDA; National Institute of Drug Abuse; Nature; Outcome Measure; Participant; Pilot Projects; Population; Prevalence; Preventive Intervention; Psychological Health; Public Health; Race; Racial Group; Randomized Clinical Trials; Recording of previous events; Relative; Relative (related person); Reliance; Reporting; Research; Research Personnel; Researchers; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Risk-Taking; Risky Behavior; Role; SUBGP; Sampling; Self Efficacy; Sensation; Social Controls; Social isolation; Social status; Societies; Stocks, Racial; Structure; Subgroup; Substance abuse problem; Survey Instrument; Surveys; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Testing; Transmission; Trials, Randomized Clinical; Virus-HIV; abstracting; abuse of substances; adult human (21+); at risk behavior; authority; base; behavior intervention; behavioral intervention; coping; demographics; drug use; effect of intervention; empowerment; follow up assessment; follow-up; high risk; improved; innovate; innovation; innovative; interventional strategy; male health; meetings; men; men who have sex with men; men who have sex with other men; men's; men's health; metropolitan; migration; pilot study; prevention service; preventional intervention strategy; psychologic; psychological; public health medicine (field); racial and ethnic; racial/ethnic; sex risk; sexually active; skills; social; social group process; social role; stress buffering; stress management; substance abuse; substance use; theories; transmission process; urban area",Risk Reduction for Urban Substance Using MSM,,24579,ZRG1,Special Emphasis Panel,,3,641781,
7758826,R01,DA,5,,02/01/2010,01/31/2011,PA-07-226,5R01DA024593-03,,NIDA:365310;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,NEUROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"NATH, AVINDRA ;",1876857;,5R01DA024593,04/01/2008,01/31/2013,"5HT transporter; 5HTT protein; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS Dementia; AIDS Dementia Complex; AIDS Virus; AIDS with dementia; AIDS-related dementia; Acquired Immune Deficiency Syndrome Virus; Acquired Immune Deficiency Syndrome related dementia; Acquired Immunodeficiency Syndrome Virus; Address; Animal Model; Animal Models and Related Studies; Anti-Retroviral Agents; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Antiretroviral Agents; Astrocytes; Astrocytus; Astroglia; Brain; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Communication, Personal; Communities; Cytokines, Chemotactic; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Developed Countries; Developed Nations; Drug abuser; Drugs; Encephalon; Encephalons; Face; Fluoxetin; Fluoxetine; Future; GFAC; Glia; Glial Cells; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HIV; HIV Dementia; HIV Infections; HIV associated dementia; HIV therapy; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-related dementia; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hawaii; Homologous Chemotactic Cytokines; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Industrialized Countries; Industrialized Nations; Injury; Intercrines; Interpersonal Communication; Investigators; Ion Channels, Calcium; Kolliker's reticulum; LAV-HTLV-III; Lymphadenopathy-Associated Virus; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Man (Taxonomy); Man, Modern; Mediating; Medication; Misuses drugs; Morbidity; Morbidity - disease rate; Mother Cells; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Stem Cell; Neurocognitive; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Opiates; Oxidative Stress; Paroxetine; Pathogenesis; Patients; Personal Communication; Pharmaceutic Preparations; Pharmaceutical Preparations; Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-; Population; Problem drug user; Production; Progenitor Cells; Property; Property, LOINC Axis 2; Proteins; Receptors, Calcium Channel Blocker; Research; Research Design; Research Personnel; Researchers; SIS cytokines; Stem cells; Study Type; Subcellular Process; T-Lymphotropic Virus Type III Infections, Human; United States; Universities; VDCC; Viral; Viral Burden; Viral Load; Viral Load result; Virus-HIV; Voltage-Dependent Calcium Channels; abused drugs; anti-retroviral; antiretroviral; cell type; chemoattractant cytokine; chemokine; clinical investigation; cytokine; design; designing; drug of abuse; drug/agent; drugs abused; drugs of abuse; effective therapy; experiment; experimental research; experimental study; facial; gene product; inhibitor; inhibitor/antagonist; macrophage; mitochondrial dysfunction; model organism; nerve cement; nerve injury; nerve stem cell; neural injury; neural progenitor cells; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal cell death; neuronal loss; neuronal progenitor; neuronal progenitor cells; neuronal toxicity; neuroprotection; neurotoxicity; novel; novel therapeutic intervention; patient population; preclinical study; research study; serotonin transporter; sodium-dependent serotonin transporter; study design",SSRI-neuroprotection for HIV/drug abuse,,24593,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,3,365310,
7765565,R01,DA,5,,02/01/2010,01/31/2011,PA-07-103,5R01DA024598-03,,NIDA:627278;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LEXINGTON,UNITED STATES,PSYCHOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"HAVENS, JENNIFER R;",7022641;,5R01DA024598,04/05/2008,01/31/2013,"AIDS; AIDS Virus; AIDS test; AIDS/HIV test; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affect; Appalachia; Appalachian Region; Area; Automobile Driving; Bears; Behavior; Blood; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Characteristics; Communities; Data; Disease; Disorder; Drivings, Automobile; Drug Prescribing; Drug Prescriptions; Drug abuse; Drug usage; Drug user; Drugs; Epidemic; Face; Generalized Growth; Goals; Growth; HBV; HCV; HCV infection; HIV; HIV Infections; HIV test; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Resources; Hepatitis B; Hepatitis B Infection; Hepatitis B Virus; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis Virus, Homologous Serum; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Immunologic Deficiency Syndrome, Acquired; Incidence; Individual; Individual Adjustment; Infection; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Interview; Interviewer; Kentucky; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Measures; Medication; Mental Health; Mental Hygiene; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NANBH; NIDA; National Institute of Drug Abuse; Network Analysis; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Participant; Pathway Analysis; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prescriptions, Drug; Prevalence; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Psychiatric Diagnosis; Psychological Health; Public Health; Questionnaires; Recruitment Activity; Reporting; Research; Research Priority; Respondent; Reticuloendothelial System, Blood; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Rural; Rural Population; Sampling; Serologic tests; Serological Tests; Seroprevalences; Social Network; Structure; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Tissue Growth; Transmission; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Urban Population; Ursidae; Ursidae Family; Viral Hepatitis B; Virus-HIV; abuse of drugs; abuses drugs; at risk behavior; design; designing; disease/disorder; driving; drug use; drug/agent; facial; health disparities; health disparity; hepatitis non A non B; hepatitis nonA nonB; high risk; innovate; innovation; innovative; interventional strategy; meetings; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; ontogeny; programs; public health medicine (field); recruit; response; rural area; serology; serum hepatitis; transmission process; urban area",Social networks and HIV risk among rural drug users,,24598,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,3,627278,
7765568,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA024672-02,,NIDA:548882;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,EUGENE,UNITED STATES,,04,084418656,US,OR,97401,"OREGON SOCIAL LEARNING CENTER, INC.","LEVE, LESLIE DIANE;",8180889;,5R01DA024672,02/15/2009,12/31/2012,"12-20 years old; 21 year old; 21+ years old; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; AOD use; Address; Adolescence; Adolescent; Adolescent Behavior; Adolescent Risk Behavior; Adolescent Youth; Adult; Age; Alcohol or Other Drugs use; American; Analysis, Cost; Behavior; Behavioral Model; Caring; Categories; Characteristics; Child Welfare; Chronic; Cost Analyses; Cost Analysis; Cost Savings; Data; Data Collection; Development; Disease; Disorder; Drug abuse; Drug usage; Drugs, Illicit; Effects, Longterm; FLR; Failure (biologic function); Female; Female Adolescents; Foundations; Future; Generalized Growth; Goals; Grant; Growth; HIV Prevention; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HIV/STD; Home; Home environment; Human, Adult; IT Systems; Illicit Drugs; Imprisonment; Independent Living; Information Systems; Information Technology Systems; Intervention; Intervention Strategies; Intervention Trial; Interview; Justice; Life; Living, Independent; Long-Term Effects; Longitudinal Studies; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mental Health; Mental Hygiene; Methods and Techniques; Methods, Other; Modeling; Oregon; Outcome; Parenting; Parenting behavior; Parents; Participant; Pathway interactions; Patient Self-Report; Pattern; Persons; Phone; Population; Populations at Risk; Prevention; Preventive Intervention; Problem behavior; Process; Psychological Health; Public Health; Randomized; Records; Relative; Relative (related person); Research; Risk; Risk Behaviors; Risky Behavior; Role; Sampling; Saving, Cost; Schools; Self-Report; Services; Social Service; Social Work; Social work (field); Societies; Specific qualifier value; Specified; Substance Use Disorder; Survey Instrument; Surveys; Symptoms; System; System, LOINC Axis 4; Systems, Data; Techniques; Telephone; Telephone Interviews; Tissue Growth; To specify; Translating; Translatings; Transmission; Woman; Work; Youth Risk Behavior; abuse of drugs; abuses drugs; adolescence (12-20); adolescent girl; adolescent trauma; adolescent welfare; adult human (21+); adult youth; analog; anti social; antisocial; at risk behavior; behavioral problem; childhood trauma; cost; cost effectiveness; criminal behavior; deviancy; deviant; disease/disorder; drug use; failure; foster care; girls; high risk; incarceration; information gathering; innovate; innovation; innovative; intergenerational; interpersonal competence; interpersonal competency; intervention development; intervention effect; interventional strategy; juvenile; juvenile human; language translation; long-term study; male; meetings; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; ontogeny; pathway; pediatric trauma; peer; prevent; preventing; preventional intervention strategy; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; service utilization; skills; social competence; social competency; social role; social skills; substance use; success; teenage; theories; therapy development; transmission process; treatment development; twenty-one year old; young adult",Juvenile Justice Girls: Pathways to Adjustment and System Use in Young Adulthood,"  Project Narrative Studies have shown that juvenile justice girls have high rates of co-occurring risk behaviors. In young adulthood, these behaviors increase the likelihood of involvement in public social service systems. We will examine the pathways to young adult adjustment among juvenile justice females, focusing on processes that reduce the likelihood of child welfare and adult corrections involvement and, ultimately, costs to society.",24672,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,2,548882,
7787466,R01,DA,5,,01/01/2010,12/31/2010,PA-08-127,5R01DA024678-02,,NIDA:619242;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ANN ARBOR,UNITED STATES,NONE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BOYD, CAROL J;",1900646;,5R01DA024678,03/15/2009,12/31/2013,"AD/HD; ADHD; AOD use; Adherence; Adherence (attribute); Adolescent; Adolescent Youth; Age Group Unspecified; Alcohol or Other Drugs use; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Anxiety; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavior; Build-it; Characteristics; Code; Coding System; Data; Demographic Factors; Drug Administration Routes; Drug usage; Drugs; Epidemiology; Esthesia; Friends; Funding; Gender; Guide prevention; Health; Heterogeneity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Individual; Ingestion; Interdisciplinary Research; Interdisciplinary Study; Interview; Investigators; Knowledge; Lead; Legal; Life; Medical; Medication; Medicine; Methods; Models, Theoretic; Motivation; Multidisciplinary Collaboration; Multidisciplinary Research; On-Line Systems; Online Systems; Pain; Painful; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physicians; Population; Prevalence; Prevention; Preventive Intervention; Problem behavior; Prospective Studies; Public Health; Race; Racial Group; Relative; Relative (related person); Research; Research Design; Research Personnel; Researchers; Respondent; Risk; Risk Factors; Route; SCHED; Sampling; Schedule; Schools; Science of Medicine; Self Medication; Sensation; Sex Characteristics; Sex Differences; Sleep; Stocks, Racial; Structure; Students; Study Section; Study Type; Study, Interdisciplinary; Substance abuse problem; Survey Instrument; Surveys; Theoretical model; Time; United States; Update; Variant; Variation; Volition; Youth; Youth 10-21; abuse of substances; adult youth; age group; analgesia; attention deficit hyperactive disorder; base; behavioral problem; cohort; design; designing; drug classification; drug use; drug/agent; falls; gender difference; heavy metal Pb; heavy metal lead; innovate; innovation; innovative; juvenile; juvenile human; medication adherence; medication compliance; nonmedical use; online computer; preventional intervention strategy; psychosocial; public health medicine (field); public health relevance; response; sedative; sex; sexual dimorphism (noncellular); social; study design; substance abuse; substance use; theories; time use; trend; web based; young adult",A Prospective Study of the Nonmedical use of Prescription Medications by Adolesce," PROJECT NARRATIVE The medical and nonmedical use of scheduled prescription medications (e.g. sleep, stimulant, anxiety/sedative, and pain) have increased among adolescents living in the United States, leading to a new set of health risks for this age group. Despite the acknowledged increase in the nonmedical use of prescription medications, relatively little is known about the reasons adolescents engage in this behavior and the negative consequences of their behaviors. The purpose of this study is to advance knowledge about adolescents' medical and nonmedical use of prescription medications with addictive potential in order to better inform prevention efforts.",24678,NSCF,Nursing Science:  Children and Families Study Section,,2,619242,
7768410,R01,DA,5,,02/01/2010,01/31/2011,PA-07-226,5R01DA024741-03,,NIDA:262474;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MILWAUKEE,UNITED STATES,PHARMACOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"LIU, QING-SONG ;",9049579;,5R01DA024741,04/01/2008,01/31/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Cocaine; Addiction, Drug; Addictive Behavior; Adverse effects; Aminalon; Aminalone; Aminobutyric Acids; Animal Model; Animal Models and Related Studies; Associative Learning; Attenuated; Behavior; Brain; Butanoic acid, 4-amino-; CB1 Receptor; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Common Rat Strains; Conditioning, Classical; Conditionings, Classical; D2 receptor; DA Neuron; DRD2; DRD2 Receptor; Dependence, Drug; Dependences, Cocaine; Development; Dopamine D2 Receptor; Dopamine neuron; Drug Addiction; Drug Dependency; Drug Therapy; Drug usage; Drugs; EC 2.7.2-; EPSP; Encephalon; Encephalons; Endocannabinoids; Excitatory Postsynaptic Potentials; Extinction; Extinction (Psychology); Extracellular Signal-Regulated Kinases; GABA; Genetic; Glutamates; Goals; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; L-Glutamate; Laboratories; Learning; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; MAP kinase; MAPK; Maintenance; Maintenances; Mammals, Rats; Mediating; Medication; Memory; Mesencephalon; Metabotropic Glutamate Receptors; Mice, Knock-out; Mice, Knockout; Mid-brain; Midbrain; Midbrain structure; Mitogen-Activated Protein Kinases; Molecular Target; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Null Mouse; Pavlovian conditioning; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Play; Property; Property, LOINC Axis 2; Rat; Rattus; Receptor Signaling; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Relapse; Rewards; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Sound; Sound - physical agent; Synapses; Synaptic; Synaptic plasticity; Testing; Therapeutic; Transmission; Treatment Side Effects; Ventral Tegmental Area; Work; abstracting; abused drugs; addiction; base; behavior test; behavioral extinction; behavioral sensitization; behavioral test; biological signal transduction; classical conditioning; clinical investigation; cocaine exposure; craving; dopaminergic neuron; driving force; drug craving; drug of abuse; drug use; drug/agent; drugs abused; drugs of abuse; gamma-Aminobutyric Acid; hedonic; in vivo; inhibitor; inhibitor/antagonist; insight; long term depression; model organism; neuronal; new therapeutics; next generation therapeutics; novel therapeutics; preference; side effect; social role; sound; therapy adverse effect; transmission process; treatment adverse effect; ventral tegmentum",Synaptic Plasticity in the Ventral Tegmental Area and Cocaine Addiction,,24741,NMB,Neurobiology of Motivated Behavior Study Section,,3,262474,
7763191,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA024872-02,,NIDA:978683;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,FARMINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"ONCKEN, CHERYL ;",6879328;,5R01DA024872,02/01/2009,01/31/2014,"Abstinence; Address; Adherence; Adherence (attribute); Aerobic Activity; Aerobic Exercise; Affect; Age; Age-Years; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bone Density; Bone Mineral Density; CDC; Cancers; Cardiovascular Diseases; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation Research; Cessation of Treatment; Cessation of smoking; Cigarette; Conditioning Therapy; Connecticut; Counseling; Coxa; Department of Health and Human Services; Department of Health and Human Services (U.S.); Depressed mood; Depression; Diagnosis; Exercise; Exercise, Physical; Female; Fracture; HHS; Health; High Prevalence; Hip; Hip region structure; History; Life Style Modification; Lung diseases; Malignant Neoplasms; Malignant Tumor; Measurement; Meditation; Mental Depression; Methods; Minnesota; Moderate Activity; Moderate Exercise; Osteoporosis; Outcome; Physical activity; Population; Populations at Risk; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Programs (PT); Programs [Publication Type]; Pulmonary Diseases; Pulmonary Disorder; QOL; Quality of life; Randomized; Recording of previous events; Relaxation; Research; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Risk; SUBGP; Self Efficacy; Site; Smoke; Smoker; Smoking; Subgroup; Symptoms; System; System, LOINC Axis 4; Technology; Time; Treatment outcome; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States Department of Health and Human Services; United States Dept. of Health and Human Services; Universities; Voice; Weight Gain; Weight Increase; Withholding Treatment; Woman; base; behavior intervention; behavioral intervention; body weight gain; body weight increase; bone fracture; cardiovascular disorder; cease smoking; compare effectiveness; depressed; improved; interest; lung disorder; malignancy; mindfulness; neoplasm/cancer; nicotine craving; non-smoking; older women; post-menopausal; postmenopausal; programs; public health relevance; randomisation; randomization; randomly assigned; reproductive; resistant; response; sadness; smoking cessation; treatment program; varenicline; wt gain",Exercise in Smoking Cessation in Postmenopausal Women," Thirty percent of female smokers are postmenopausal, and this proportion is expected to grow as the population ages. An effective exercise program added to smoking cessation for postmenopausal women has the potential to increase smoking cessation rates, address many health problems in this at-risk population, and markedly improve quality of life.",24872,ZDA1,Special Emphasis Panel,,2,978683,
7754132,R01,DA,5,,01/01/2010,12/31/2010,PA-07-333,5R01DA025032-02,,NIDA:362588;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LEXINGTON,UNITED STATES,PSYCHOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"RUSH, CRAIG R;",1892429;,5R01DA025032,01/01/2009,12/31/2013,"3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abstinence; Adanon; Addiction, Cocaine; Addiction, Opiate; Admission; Admission activity; Agonist; Althose; American; Animals, Laboratory; Attenuated; Behavior; Behavioral; Behavioral Mechanisms; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Benzeneethanamine, alpha-methyl-, (S)-; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cocaine; Cocaine Dependences; Cocaine Users; Crystal Meth; Deoxyephedrine; Dependence; Dependence, Opiate; Dependences, Cocaine; Desoxyephedrine; Dexamfetamine; Dexedrine; Dextroamphetamine; Dolophine; Dose; Drug Therapy; Drugs; Educational process of instructing; Engineering; Engineerings; Epidemiology; Goals; Great Lakes Region; History; Human; Human, General; Institution; Intelligence; Intracellular Communication and Signaling; Kentucky; Laboratories; Laboratory Animals; Laboratory Procedures; Laboratory Study; Learning; Location; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mechanisms of Behavior and Behavior Change; Mediating; Medication; Methadone; Methadose; Methamphetamine; Methamphetamine dependence; Methods; Methylamphetamine; Modeling; N-Methylamphetamine; Nicotine; Nicotine Replacement Therapy; Opiate Addiction; Organ System, Cardiovascular; PBO; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Placebos; Prevention of relapse; Procedures; Psychostimulant dependence; Public Health; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Questionnaires; Recording of previous events; Relapse; Replacement Therapy; Reporting; Research; Safety; Self Administration; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Teaching; Testing; Uncertainty; Users, Cocaine; Vascular, Heart; bench bed side; bench bedside; bench to bed side; bench to bedside; biological signal transduction; circulatory system; clinical effect; clinical efficacy; clinical investigation; d-Amphetamine; design; designing; dextro-Amphetamine; disorder later incidence prevention; doubt; drug abstinence; drug discrimination; drug/agent; effective therapy; experiment; experimental research; experimental study; indexing; methamphetamine abuse; nicotine replacement; novel; opioid addiction; opioid dependence; preclinical study; prevent; preventing; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; psychostimulant addiction; public health medicine (field); public health relevance; research study; sham therapy; stimulant addiction; stimulant dependence; volunteer",Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab Studies,,25032,ZDA1,Special Emphasis Panel,,2,362588,
7765566,R01,DA,5,,02/01/2010,01/31/2011,PAR-06-114,5R01DA025039-03,,NIDA:567938;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHICAGO,UNITED STATES,PSYCHIATRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"MUSTANSKI, BRIAN ;",8319315;,5R01DA025039,04/10/2008,01/31/2013,"0-11 years old; AIDS Virus; AOD use; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adolescent; Adolescent Youth; African; African American; Afro American; Afroamerican; Age; Alcohol abuse; Alcohol or Other Drugs use; American; Americas; Basic Research; Basic Science; Behavior; Behavioral; Bioethicist; Bioethics Consultants; Biological; Black Populations; Black or African American; Candidate Disease Gene; Candidate Gene; Care Givers; Caregivers; Censuses; Child; Child Youth; Children (0-21); Communities; Complement; Complement Proteins; Consultations; Control Groups; Crime; DNA; Data; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Disadvantaged; Drug usage; Environment; Environmental Toxin; Ethics; Exposure to; Family; Funding; Gender; Genes; Genetic; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genotype; Goals; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Housing; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Child; Individual; Inherited Predisposition; Inherited Susceptibility; Intervention; Intervention Strategies; Investigators; Knowledge; LAV-HTLV-III; Life; Lymphadenopathy-Associated Virus; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Modeling; Models, Theoretic; Natural experiment; Neighborhoods; Nerve Transmitter Substances; Neurobiology; Neurotransmitters; Participant; Patient Self-Report; Personality; Poverty; Process; Public Housing; R01 Mechanism; R01 Program; RPG; Race; Racial Group; Relative; Relative (related person); Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Risk; Risk Behaviors; Risk-Taking; Risky Behavior; Role; Sampling; Self-Report; Services; Staging; Stocks, Racial; Survey Instrument; Surveys; T-Lymphotropic Virus Type III Infections, Human; Teen; Teenagers; Teens; Testing; Theoretical model; Time; Toxic Environmental Agents; Toxic Environmental Substances; Virus-HIV; Work; Youth; Youth 10-21; alcohol problem; at risk behavior; behavior change; black American; children; clinical data repository; clinical data warehouse; data repository; dissemination research; drug use; environment effect on gene; environmental toxicant; ethanol abuse; externalizing behavior; gene environment interaction; genetic etiology; genetic mechanism of disease; genetic vulnerability; girls; hazardous alcohol use; high risk sex activity; high risk sex behavior; high risk sexual activity; high risk sexual behavior; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; meetings; neurobiological; novel; parent monitoring; parental monitoring; problem drinking; protective effect; pubertal timing; relational database; risky sexual behavior; social role; substance use; teen years; youngster",Gene-Environment Interaction Effects on HIV Risk,,25039,ZRG1,Special Emphasis Panel,,3,567938,
7744051,R01,DA,5,,12/01/2009,11/30/2010,PA-07-110,5R01DA025192-02,,NIAAA:99002;NIDA:750494;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MIAMI,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"PRADO, GUILLERMO ;",7972661;,5R01DA025192,12/15/2008,11/30/2013,"AIDS Virus; AIDS/HIV; AIDS/HIV problem; AOD use; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adolescent; Adolescent Risk Behavior; Adolescent Youth; African American; Afro American; Afroamerican; Age; Alcohol or Other Drugs use; Americas; Amphetamines; Attention; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Black Populations; Black or African American; CDC; Categories; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cigarette; Clinical Trials Design; Coitus; Communication; Communities; Community Practice; Conditioning Therapy; County; Dependence; Development; Drug usage; Drugs; Drugs, Illicit; Education for Intervention; Educational Intervention; Effectiveness; Ethnic and Racial Minorities; Ethnic group; Family; Family Study; Frequencies (time pattern); Frequency; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; Guidelines; HIV; HIV/AIDS; HIV/AIDS problem; HTLV-III; Health; High-Risk Sex; Hispanic Populations; Hispanics; Hispanics or Latinos; Human Immunodeficiency Viruses; Human Sexual Intercourse; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Illicit Drugs; Instruction Intervention; Intervention; Intervention Strategies; Knowledge; LAV-HTLV-III; Latino Population; Life Style Modification; Linear Models; Lymphadenopathy-Associated Virus; Manuals; MeSH Descriptors Class 4; Mediating; Medication; Minority Groups; Modeling; Non-Hispanic; Not Hispanic or Latino; Outcome; Parenting; Parenting behavior; Parents; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Prevention Research; Preventive Intervention; Problem behavior; Public Health; Publishing; Randomized; Randomized Controlled Trials; Relative; Relative (related person); Reporting; Risk Factors; Sampling; Sex Behavior; Sexual Activity; Sexual Behavior; Sexual Intercourse; Societies; Spanish Origin; Staging; Substance abuse problem; System; System, LOINC Axis 4; Testing; Time; Training; Training Intervention; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Unprotected Sex; Unsafe Sex; Virus-HIV; Youth; Youth 10-21; Youth Risk Behavior; abuse of substances; adolescent substance use; behavior intervention; behavioral intervention; behavioral problem; black American; community setting; design; designing; drug use; drug/agent; effective intervention; effectiveness trial; efficacy trial; geographic site; health disparities; health disparity; hispanic community; improved; instructional intervention; intervention effect; interventional strategy; juvenile; juvenile human; meetings; middle school; parent monitoring; parental involvement; parental monitoring; peer; prevent; preventing; prevention service; preventional intervention strategy; primary outcome; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; sex activity; substance abuse; substance use; substance use prevention; youth substance use",Familias Unidas Stage III Study: Preventing Substance Abuse in Hispanic Youth," The objective of the proposed study is to reduce illicit drug use, cigarette use, and unsafe sexual behavior health disparities in Hispanic populations. The knowledge expected to be gained from this study will aid in the development of effective interventions to reduce drug use, cigarette use, unprotected sexual behavior, and HIV in Hispanic adolescents.",25192,CLHP,Community-Level Health Promotion Study Section,,2,849496,
7781400,R01,DA,5,,02/28/2010,02/27/2011,PA-07-070,5R01DA025201-02,,NIDA:350831;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BERRETTINI, WADE H;",2419733;,5R01DA025201,03/01/2009,02/27/2014,"Accounting; Adoption; Allele Frequency; Alleles; Allelic Imbalance; Allelomorphs; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biology; Brain; Candidate Disease Gene; Candidate Gene; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cells; Cessation of Treatment; Cessation of smoking; Chromosome 15; Chromosomes, Human, Pair 15; Cigarette; Code; Coding System; Complex; Cross-Product Ratio; DNA; Data; Deoxyribonucleic Acid; Dependence, Nicotine; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Encephalon; Encephalons; Europe; European; Exons; GWAS; Gene Cluster; Gene Expression; Gene Frequency; Gene Transcription; Genes; Genetic; Genetic Transcription; Genotype; Haplotypes; Heritability; Human; Human, General; In Vitro; Individual; Investigators; Learning; Ligand Binding Protein; Linkage Disequilibrium; Linkage Disequilibriums; Man (Taxonomy); Man, Modern; Medication; Messenger RNA; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nervous System, Brain; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; North America; Odds Ratio; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Population; Predisposition; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; RNA Expression; RNA Splicing; RNA, Messenger; Receptor Gene; Relative Odds; Reporter; Reporting; Research; Research Personnel; Researchers; Rewards; Risk; Risk Ratio; Rosa; Rose; Sample Size; Smoker; Smoking; Source; Splicing; Surgeon; Susceptibility; Tobacco; Transcription; Transcription, Genetic; Twin Multiple Birth; Twin Studies; Twins; United States; Variant; Variation; Withholding Treatment; allelic frequency; case control; cease smoking; cigarette smoking; drug development; drug/agent; experiment; experimental research; experimental study; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; interest; mRNA; nicotine addiction; novel; public health relevance; research study; smoke cigarette; smoking cessation; tissue culture; trait; whole genome association studies; whole genome association study",Genetics of Nicotine Dependence, NARRATIVE This research proposes to study DNA variations in genes which produce brain binding proteins for nicotine. These binding proteins are involved in the development of nicotine addiction. Understanding the function consequences of these DNA variations will provide direction in developing new medications for nicotine addiction.,25201,GHD,Genetics of Health and Disease Study Section,,2,350831,
7777391,R01,DA,5,,02/01/2010,01/31/2011,PA-07-070,5R01DA025267-02,,NIDA:330784;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN ANTONIO,UNITED STATES,PHARMACOLOGY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"MCMAHON, LANCE R;",2241108;,5R01DA025267,04/01/2009,01/31/2014,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 1,2,3,4,5,6-hexahydro-1,5-methano-8H- pyrido(1,2-a)(1,5)diazocin-8-one; 21+ years old; Address; Adult; Agonist; Amfebutamone; Assay; Attenuated; Behavioral; Behavioral Assay; Bioassay; Biologic Assays; Biological Assay; Bupropion; Cancer Cause; Cancer Etiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Catecholamines; Cause of Death; Cessation of smoking; Chemicals; Chronic; Dependence; Dependence, Nicotine; Dimensions; Dose; Drug Therapy; Drugs; Effectiveness; FLR; Failure (biologic function); Grant; Health; Human, Adult; Individual; Lead; Ligands; Lung diseases; Macaca mulatta; Measures; Mediating; Medication; Monkeys; Neuropharmacology; Nicotine; Nicotine Dependence; Nicotine Skin Patch; Nicotine Withdrawal; Organ System, Cardiovascular; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Play; Procedures; Pulmonary Diseases; Pulmonary Disorder; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Receptor Protein; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Site; Stimulus; Sympathins; Testing; Therapeutic; Tobacco Consumption; Tobacco smoke; Tobacco use; Training; United States; Vascular, Heart; Withdrawal; Work; adult human (21+); base; buproprion; cardiovascular disorder; cease smoking; cigarette smoking; circulatory system; citizine; comparative efficacy; cystisin; cytisine; cytiton; drug discrimination; drug/agent; failure; heavy metal Pb; heavy metal lead; in vivo; indexing; inhibitor; inhibitor/antagonist; lung disorder; nicotine addiction; nicotine patch; novel; pre-clinical; preclinical; preclinical study; public health relevance; receptor; reinforcer; reuptake; smoke cigarette; smoking cessation; social role; varenicline",Nicotine dependence: neuropharmacology in monkeys," Relevance Cigarette smoking is a leading cause of cancer and cardiovascular disease and is the leading preventable cause of death in adults (10% annually). This grant investigates the receptor pharmacology of currently approved medications for smoking cessation and could lead to better treatment, thereby decreasing the devastating health consequence of tobacco use.",25267,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,2,330784,
7779397,R01,DA,5,,02/01/2010,01/31/2011,PA-07-409,5R01DA025548-02,,NIDA:624606;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHICAGO,UNITED STATES,,05,074438755,US,IL,606143394,CHILDREN'S MEMORIAL HOSPITAL (CHICAGO),"GAROFALO, ROBERT  (contact);MUSTANSKI, BRIAN ;",8319315;8408169 (contact);,5R01DA025548,04/01/2009,01/31/2014,"12-20 years old; 19 year old; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; AOD use; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adolescence; Adolescent; Adolescent Youth; Affect; Age; Alcohol or Other Drugs use; Anti-HIV Positivity; Arts; Automobile Driving; Biological; Categories; Clinical; Computers; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Depression and Suicide; Development; Diagnosis; Disease Frequency Surveys; Drivings, Automobile; Drug usage; Drugs, Illicit; Early identification; Epidemic; Epidemiology; Exposure to; Face; Family; Gays; Generalized Growth; Goals; Growth; HIV; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Prevention; HIV Seroconversion; HIV Seropositivity; HIV diagnosis; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Illicit Drugs; Infection; Influentials; Intervention; Intervention Strategies; Interview; Knowledge; LAV-HTLV-III; Link; Lymphadenopathy-Associated Virus; Male Adolescents; Markov Chains; Markov Process; Mental Health; Mental Hygiene; Minority; Modeling; Models, Statistical; Natural History; Orientation, Sexual; Participant; Pilot Projects; Population; Preparedness; Prevalence; Prevalence Study; Preventive Intervention; Probabilistic Models; Psychological Health; Psychopathology; Readiness; Recruitment Activity; Relative Risks; Reporting; Research; Respondent; Risk; Risk Behaviors; Risk-Taking; Risks, Relative; Risky Behavior; Sampling; Sex Orientation; Statistical Models; Stress; Structure; Study, Prevalence; Substance abuse problem; Suicide; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Target Populations; Testing; Time; Tissue Growth; Vacuum; Violence; Virus-HIV; Vulnerable Populations; Woman; Youth; Youth 10-21; abnormal psychology; abuse of substances; adolescence (12-20); adolescent boy; antibody positive AIDS test; antigen positive AIDS test; at risk behavior; base; biopsychosocial; design; designing; driving; drug use; emerging adulthood; experience; facial; fatal attempt; fatal suicide; health disparities; health disparity; high risk; innovate; innovation; innovative; intent to die; intervention development; interventional strategy; juvenile; juvenile human; male; men; men who have sex with men; men who have sex with other men; men's; nineteen year old; ontogeny; peer; pilot study; prevent; preventing; preventional intervention strategy; psychosocial; public health priorities; public health relevance; racial/ethnic difference; recruit; seropositive (AIDS test); substance abuse; substance use; suicidality; teenage; theories; therapy development; treatment development; violent; violent behavior",Syndemic Development and HIV Risk Among Vulnerable Young Men," Young men who have sex with men (YMSM) are at elevated risk for a syndemic of biopsychosocial health problems. This syndemic includes HIV risk, substance use, internalizing mental health problems, and violence exposure. The overarching goal of this study is to collect information on YMSM-specific risk and protective factors, which can then be used to inform the development of an intervention targeting this vulnerable population.",25548,BSCH,Behavioral and Social Consequences of HIV/AIDS Study Section,,2,624606,
7756675,R01,DA,5,,01/01/2010,12/31/2010,PA-07-122,5R01DA025555-02,,NIDA:665606;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RUGER, JENNIFER P;",2059474;,5R01DA025555,01/15/2009,12/31/2012,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; AOD use; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Admission; Admission activity; Adolescent; Adolescent Youth; Advisory Committees; Alcohol or Other Drugs use; Alcohols; Analysis, Cost; Area; Arm; Behavior; Behavior Therapy, Cognitive; Behavioral; Behavioral Therapy; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Birth Weight; Build-it; Cessation of life; Cessation of smoking; Chemical Class, Alcohol; Childhood; Cocaine; Cognitive; Cognitive Therapy; Communities; Contracting Opportunities; Contracts; Cost Analyses; Cost Analysis; Cost Savings; Costs and Benefits; Costs and Cost Analyses; Costs and Cost Analysis; Crystal Meth; Data; Death; Deoxyephedrine; Desoxyephedrine; Drug abuse; Drug usage; Economic Policy; Economics; Effectiveness; Effectiveness of Interventions; Ensure; Ethnic and Racial Minorities; Evaluation Studies; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Funding; Future; Gestation; Goals; Guidelines; HIV; HIV Infections; HIV Prevention; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Health Benefit; Health Care Research; Health Services Evaluation; Health Services Research; Health, Infant; Healthcare Research; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Improve Access; Indirect Costs; Individual; Infant Health; Intensive Care Units, Neonatal; Intervention; Intervention Strategies; LAV-HTLV-III; Length of Stay; Low Birth Weight Infant; Lymphadenopathy-Associated Virus; Marihuana; Math Models; Measurement; Measures; Medical; Medical Care Research; Medicine; Methamphetamine; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Methylamphetamine; Minority Groups; Mothers; N-Methylamphetamine; NIDA; National Institute of Drug Abuse; Neonatal Intensive Care Units; Newborn Intensive Care Units; Nicotine; Number of Days in Hospital; Outcome; Participant; Perinatal; Policy Research; Policy, Economic; Pregnancy; Pregnant Women; Prenatal care; Prevention; Prevention program; Problem behavior; Programs (PT); Programs [Publication Type]; Psychotherapy, Cognitive; Public Health; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Quality-Adjusted Life Years; Randomized Controlled Trials; Relative; Relative (related person); Reporting; Research; Research Resources; Resources; Risk; Risk Behaviors; Risk Reduction; Risky Behavior; Saving, Cost; Savings; Science of Medicine; Services; Sex Behavior; Sexual Activity; Sexual Behavior; Sound; Sound - physical agent; Standardization; Substance abuse problem; T-Lymphotropic Virus Type III Infections, Human; Task Forces; Techniques; Therapy, Cognition; Translating; Translatings; Underserved Population; United States; Upper arm; VLBW (human); Virus-HIV; Vulnerable Populations; Woman; Work; abuse of drugs; abuse of substances; abuses drugs; at risk behavior; behavioral problem; cease smoking; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; cost; cost effectiveness; drug use; economic evaluation; effect of intervention; evidence base; health disparities; health disparity; high risk; hospital days; hospital length of stay; hospital stay; improved; infancy; infantile; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; language translation; life time cost; lifetime cost; low birth weight infant human; low birthweight; mathematical model; mathematical modeling; member; motivational enhancement therapy; motivational interview; offspring; pediatric; prevention service; programs; public health medicine (field); public health relevance; randomized controlled study; services research; sex activity; smoking cessation; sound; substance abuse; substance use; under served population; underserved people",Economic Evaluation of Drug Abuse Treatment and HIV Prevention Services for Pregn," PROJECT NARRATIVE Drug abuse and high risk HIV behavior during pregnancy are major public health problems in the United States due to their impact on individual users, their offspring, and surrounding communities. Drug abuse and HIV prevention programs targeting pregnant women have the potential to be cost-effective due to the resultant fewer low-birth-weight babies and perinatal deaths, fewer physical, cognitive and behavioral problems during infancy and childhood, and the significant health benefits that can accrue to the mother. The overall objective of this study is to conduct the first economic evaluation of an innovative behavioral approach integrating Motivational Enhancement Therapy with Cognitive Behavioral Therapy (MET-CBT) as compared to standard Brief Advice (BA) within prenatal care to decrease use of a full range of substances (e.g., marijuana, cocaine, methamphetamines, alcohol, nicotine), to reduce HIV risk behavior and to achieve better infant health outcomes (e.g. longer gestations, greater birth weight, reduced medical consequences such as admission and length of stay in the Neonatal Intensive Care Unit (NICU)).",25555,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,2,665606,
7762206,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA025607-02,,NIDA:625178;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ATLANTA,UNITED STATES,PSYCHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"STERK, CLAIRE E;",1887814;,5R01DA025607,02/01/2009,11/30/2012,"21+ years old; AIDS/HIV; AIDS/HIV problem; AOD use; Address; Adult; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Alcohol or Other Drugs use; Alcoholism; Application Context; Area; Behavior; Behavioral; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Black Populations; Black or African American; Cancers; Cardiovascular Diseases; Categories; Causality; Censuses; Characteristics; Communities; Crime; Crystal Meth; Data; Data Sources; Deoxyephedrine; Desoxyephedrine; Development; Diacetylmorphine; Diamorphine; Disadvantaged; Disease; Disorder; Disorganization, Social; Drug usage; Drug user; Drugs; Drugs, Illicit; ETOH level; Elderly; Elderly, over 65; Enrollment; Epidemiology; Etiology; Exercise; Exercise, Physical; Frequencies (time pattern); Frequency; Future; Gender; Grouping; HIV/AIDS; HIV/AIDS problem; Health; Heroin; Hot Spot; Hot Spots (Area of Increased Mortality); Human, Adult; Illicit Drugs; Imprisonment; Individual; Infrastructure; Intervention; Intervention Strategies; Interview; Knowledge; Life; Linear Models; Malignant Neoplasms; Malignant Tumor; Measures; Medication; Mental disorders; Mental health disorders; Methamphetamine; Methylamphetamine; Modeling; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); N-Methylamphetamine; Neighborhoods; Nutrition; Nutritional Science; Obesity; Outcome; PROV; Participant; Pattern; Perception; Pharmaceutic Preparations; Pharmaceutical Preparations; Police; Policy Maker; Population; Prevalence; Preventive Intervention; Process; Provider; Proxy; Psychiatric Disease; Psychiatric Disorder; Research; Research Infrastructure; Respondent; SAMHSA; STD; Science of nutrition; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Social Disorganizations; Social Environment; Social Health Services; Societies; Socio-economic status; Socioeconomic Status; Sources, Data; Status, Socioeconomic; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Tobacco; United States; United States Substance Abuse and Mental Health Services Administration; Unspecified Mental Disorder; Venereal Diseases; Venereal Disorders; Venereal Infections; Woman; adiposity; adult human (21+); advanced age; alcohol level; alcohol measurement; base; black American; cardiovascular disorder; cocaine use; contextual factors; corpulence; corpulency; corpulentia; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug use; drug/agent; elders; enroll; ethanol measurement; ethyl alcohol measurements; geriatric; groupings; incarceration; inner city; insight; interventional strategy; late life; later life; malignancy; men; men's; mental illness; neoplasm/cancer; nutrition; obese; obese people; obese person; obese population; older adult; older person; preventional intervention strategy; psychological disorder; public health relevance; senior citizen; social; social climate; social context; socioenvironment; substance use; theories",Neighborhood Effects on Drug Use Among African American Adults,,25607,CIHB,Community Influences on Health Behavior,,2,625178,
7754037,R01,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R01DA025647-02,,NIDA:297000;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"ELMER, GREGORY I (contact);KAFKAFI, NERI ;",2085421 (contact);9351386;,5R01DA025647,01/01/2009,12/31/2011,"21+ years old; Adopted; Adult; Affect; Algorithms; Animal Model; Animal Models and Related Studies; Animals; Anti-Anxiety Agents; Anti-Anxiety Drugs; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Anxiolytic Agents; Anxiolytics; Area; Behavior; Behavioral; Behavioral Assay; Behavioral Genetics; Bio-Informatics; Bioinformatics; Biological; Biomedical Research; Brain; Budgets; Cancers; Chronic; Classification; Cognitive Discrimination; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Development; Development and Research; Discrimination; Discrimination (Psychology); Disturbance in cognition; Dose; Drug Evaluation, Preclinical; Drug Industry; Drug Screening; Drug abuse; Drugs; Drugs, Illicit; Emotional; Encephalon; Encephalons; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Exploratory Behavior; Fingerprint; Foundations; Future; Genetic; Genetic Determinants of Behavior; Genetics, Behavioral; Goals; Grant; Health Care Costs; Health Costs; Healthcare Costs; Human; Human, Adult; Human, General; Illicit Drugs; Impaired cognition; In Vitro; Individual; Industry, Pharmaceutic; Intervention; Intervention Strategies; Investments; Isokinetic Exercise; Isokinetics; Isotonic Exercise; Isotonics; Log-Linear Models; Major Tranquilizers; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Masks; Measures; Medication; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Mining; Minings; Models, Log-Linear; Models, Statistical; Molecular; Movement; NIH; Names; National Institutes of Health; National Institutes of Health (U.S.); Nerve Degeneration; Nervous System, Brain; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neuron Degeneration; New Drug Approvals; Opioid; Pathology; Pattern; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacology; Pharmacology-Psychopharmacology; Population; Preclinical Drug Evaluation; Probabilistic Models; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Psychoactive Agents; Psychoactive Compound; Psychoactive Drugs; Psychopharmaceuticals; Psychopharmacology; Psychopharmacology / Toxicology; Psychotropic Drugs; QOL; Quality of life; R & D; R&D; Reporting; Rest; Screening Result; Screening procedure; Statistical Models; Structure; System; System, LOINC Axis 4; Systematics; Systems Biology; Techniques; Testing; Therapeutic; Time; Tranquilizing Agents, Major; Tranquilizing Agents, Minor; Treatment Efficacy; Trees; United States; United States National Institutes of Health; Unspecified Mental Disorder; Work; abuse of drugs; abused drugs; abuses drugs; adult human (21+); antianxiety agent; application in practice; base; behavior genetics; body movement; clinical data repository; clinical data warehouse; cognitive dysfunction; cognitive loss; cognitively impaired; data mining; data repository; datamining; design; designing; detector; drug development; drug discovery; drug of abuse; drug/agent; drugs abused; drugs of abuse; experience; improved; in vivo; innovate; innovation; innovative; interest; interventional strategy; malignancy; mental illness; model organism; neoplasm/cancer; neural degeneration; neurodegeneration; neuronal degeneration; neuropathology; novel; practical application; psychological disorder; psychopharmacologic; psychopharmacological; public health relevance; relational database; research and development; response; screening; screenings; success; therapeutic efficacy; therapeutic target; therapeutically effective",Pattern array: in vivo mining for novel psychoactive drug discovery,,25647,ZRG1,Special Emphasis Panel,,2,297000,
7771703,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA025694-02,,NIDA:634489;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MIAMI,UNITED STATES,PSYCHIATRY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"SCHWARTZ, SETH J;",6602731;,5R01DA025694,02/15/2009,11/30/2013,AOD use; Acculturation; Acculturations; Adolescent; Adolescent Behavior; Adolescent Youth; Age; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; American; Arts; Behavior; Behavioral; Caring; Cognitive Discrimination; Cultural Assimilation; Development; Discrimination; Discrimination (Psychology); Drug usage; Drugs; EtOH drinking; Family; Goals; Happiness; Happinesses; Hispanic Americans; Hispanic Populations; Hispanics; Hispanics or Latinos; Immigrant; Immigrations; In-Migration; Intervention; Intervention Strategies; Latino Population; Lead; Los Angeles; Measures; Mediating; Medication; Methods; Modeling; Outcome; Parents; Pb element; Perception; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Problem behavior; Process; Reporting; Risk; Risk Behaviors; Risk-Taking; Risky Behavior; Role; Schools; Services; Sex Behavior; Sexual Activity; Sexual Behavior; Site; Social Identification; Social Identity; Spanish Americans; Spanish Origin; Specific qualifier value; Specified; Sum; Testing; Time; United States; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; at risk behavior; behavioral problem; drug use; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; heavy metal Pb; heavy metal lead; high school; hispanic community; indexing; interventional strategy; juvenile; juvenile human; positive attitude; prevent; preventing; public health relevance; sex activity; social role; substance use; theories; trait,The Role of Culture in Thriving and Risk Behavior in Hispanic Adolescents,,25694,SPIP,"Social Psychology, Personality and Interpersonal Processes Study Section",,2,634489,
7755816,R01,DA,5,,01/01/2010,12/31/2010,PA-07-113,5R01DA026291-02,,NIDA:346809;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ATHENS,UNITED STATES,PSYCHOLOGY,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"EBY, LILLIAN T;",8027470;,5R01DA026291,01/15/2009,12/31/2012,"Administrator; Adoption; Alcoholism; Behavior; Behavioral; Belief; Cereals; Characteristics; Client; Clinical Trials Network; Cognitive; Competence; Data; Dependence, Nicotine; Dependence, Tobacco; Distal; Employee; FLR; Failure (biologic function); Focus Groups; Fostering; Funding; Goals; Grain; Health; Health Policy; Individual; Job Environment; Job Location; Job Place; Job Setting; Job Site; Jobs; Justice; Link; Mediating; NIDA; National Institute of Drug Abuse; New York; Nicotine Dependence; Occupations; Organizational Change; Outcome; Patients; Perception; Process; Professional Postions; Programs (PT); Programs [Publication Type]; Reaction; Regulation; Research; Sampling; Self Efficacy; Services; Smoke; Smoker; Smoking; Smoking Status; Stress; Substance Abuse Treatment Centers; Substance abuse problem; Textiles; Time; Tobacco; Tobacco Cessation; Tobacco Consumption; Tobacco Dependence; Tobacco Use Cessation; Tobacco use; Treatment outcome; Uncertainty; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; abuse of substances; addiction; burnout; clinical practice; doubt; experience; fabric; failure; health care policy; implementation science; innovate; innovation; innovative; meetings; nicotine addiction; policy implication; programs; psychologic; psychological; public health relevance; social; substance abuse; theories; tobacco addiction; treatment center; treatment program; volunteer; work environment; work setting",Understanding the Adoption and Implementation of Tobacco-Free Regulation in Subst," Project Narrative Clinicians' perceptions of the implementation of the OASAS tobacco-free regulation are expected to relate to psychological and cognitive reactions, which in turn is proposed to relate to psychological, behavioral, and physical strain. Clinicians working in substance abuse treatment facilities are already working in a high stress, high burnout occupation. Thus, understanding the additive effects of the implementation of this top-down driven, restrictive, state-mandated regulation on clinicians has substantial individual health and health policy implications.",26291,ZDA1,Special Emphasis Panel,,2,346809,
7762208,R01,DA,5,,12/01/2009,11/30/2010,PA-07-070,5R01DA026652-17,,NIDA:238190;NIMH:304554;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BALTIMORE,UNITED STATES,OTHER HEALTH PROFESSIONS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"EATON, WILLIAM W;",1897353;,5R01DA026652,04/01/1992,11/30/2013,"Active Follow-up; Affect; Affective Disorders; Affective Psychosis, Bipolar; Alcohols; Antisocial Personality; Antisocial Personality Disorder; Anxiety Disorders; Automobile Driving; Baltimore; Behavior; Bipolar Disorder; Catchment Area; Categories; Cause of Death; Cessation of life; Characteristics; Chemical Class, Alcohol; Communities; Criminal Justice; DSM; Data; Death; Death Certificates; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Dimensions; Direct Costs; Disease; Disorder; Documentation; Drivings, Automobile; Drugs; Emotional well being; Employment; Ethnic Origin; Ethnicity; Ethnicity aspects; Evolution; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Feels well; Funding; General Population; General Public; Health Facilities; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Health care facility; Healthcare Facility; History; Household; ICD Code; IT Systems; Indirect Costs; Individual; Information Systems; Information Technology Systems; International Classification of Disease Codes; Interview; Justice, Criminal; Life; Life Expectancy; Link; Literature; Marital Status; Maryland; Measures; Medicaid; Medicare; Medicare/Medicaid; Medication; Mental disorders; Mental health disorders; Mental well-being; Mood Disorders; Mortality; Mortality Vital Statistics; Motor Vehicles; Normal mental condition; Normal mental state; Normal psyche; Participant; Personality; Personality Disorders; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Poverty; Programs (PT); Programs [Publication Type]; Psyche structure; Psychiatric Diagnosis; Psychiatric Disease; Psychiatric Disorder; Psychiatric therapeutic procedure; Psychological Well Being; Psychopathology; Psychosis, Manic-Depressive; Public Health; Race; Racial Group; Recording of previous events; Records; Reporting; Research; Research Resources; Resources; Respondent; Retirement; Risk; SCHED; Sampling; Schedule; Schizophrenia; Schizophrenic Disorders; Sense of well-being; Site; Social Functioning; Socio-economic status; Socioeconomic Status; Sociopathic Personality; Status, Socioeconomic; Stocks, Racial; Survivors; Suspension substance; Suspensions; Symptoms; Syndrome; System; System, LOINC Axis 4; Systems, Data; Title 18; Treatment Cost; Unemployment; United States; Unspecified Mental Disorder; Variant; Variation; Well in self; abnormal psychology; base; bipolar affective disorder; cohort; common treatment; community setting; cost; criminal behavior; dementia praecox; disability; disease/disorder; driving; drug/agent; follow-up; functional outcomes; health insurance for disabled; improved; indexing; jobless; joblessness; manic depressive disorder; manic depressive illness; mental; mental illness; out of work; population based; programs; psychiatric care; psychiatric therapy; psychiatric treatment; psychologic; psychological; psychological disorder; psychological wellness; public health medicine (field); public health relevance; schizophrenic; self wellness; social; socioeconomic; socioeconomically; socioeconomics; suspension; unemployed",Evolution of Psychopathology in the Population," EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATION 7. PROJECT NARRATIVE  This project will provide the most accurate estimates available in the United States of the long-term consequences of common mental disorders for mortality, direct and indirect costs, social functioning, and psychological well-being. It will show the consequences of receiving, and not receiving, treatment for common mental disorders. Documentation of mortality, costs, and consequences provides basic information for the public health approach to mental disorders.",26652,ZRG1,Special Emphasis Panel,,17,542744,
7789601,R01,DA,5,,02/01/2010,01/31/2011,PA-08-127,5R01DA027222-02,,NIDA:322204;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"DAFNY, NACHUM ;",1963043;,5R01DA027222,04/01/2009,01/31/2014,"0-11 years old; 2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 21+ years old; AD/HD; ADHD; Academy; Adolescent; Adolescent Psychiatry; Adolescent Youth; Adult; Affect; American; Anesthesia; Anesthesia procedures; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Animal Behavior; Animals; Area; Attention Deficit Disorder; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Aves; Avian; Basic Research; Basic Science; Behavior; Behavior, Animal; Behavioral; Behavioral Assay; Benefits and Risks; Birds; Brain; Cell Nucleus; Central Nervous System; Characteristics; Child; Child Youth; Children (0-21); Cognitive; Common Rat Strains; DNA Alteration; DNA mutation; Data; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Therapy; Drug abuser; Drugs; Effects, Longterm; Electrodes; Encephalon; Encephalons; Event; Gene Alteration; Gene Mutation; Genetic mutation; Human, Adult; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Implant; In Vitro; Injection of therapeutic agent; Injections; Investigation; Journals; Knowledge; Laboratories; Lesion; Locus Coeruleus; Long-Term Effects; Magazine; Mammals, Rats; Medication; Methylphenidate; Misuses drugs; Molecular; NIDA; National Institute of Drug Abuse; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurochemistry; Neurocyte; Neurons; Nucleus; Nucleus Pigmentosus Pontis; Patients; Peptide Biosynthesis, Ribosomal; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiology; Prefrontal Cortex; Problem drug user; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Protocol; Protocols documentation; Publications; Rat; Rattus; Records; Reporting; Research; Ritalin; Science of neurochemistry; Science of neurophysiology; Scientific Publication; Sequence Alteration; Site; Slice; Structure; Structure of locus ceruleus; System; System, LOINC Axis 4; Testing; Time; Up-Regulation; Up-Regulation (Physiology); Upregulation; Ventral Tegmental Area; adult animal; adult human (21+); adult youth; attention deficit hyperactive disorder; attenuation; base; behavior observation; behavioral observation; behavioral sensitization; behavioral tolerance; blue nucleus; children; drug/agent; experiment; experimental research; experimental study; in vivo; juvenile; juvenile human; locus ceruleus structure; mature animal; neurochemistry; neuronal; neurophysiology; protein synthesis; psychostimulant; public health relevance; raphe nuclei; research study; response; ventral tegmentum; young adult; youngster",How and Where Methylphenidate Exerts Effect in Adolescent and Adult Brains," Narrative Attention deficit disorder (ADHD) is treated by psychostimulant such as Ritalin for prolonged period of time, and its long term effect is unknown. Most studies of Ritalin using animals under anesthesia or brain slices, anesthesia is known to affect brain activity and interact with the drug under investigation. The objective of this proposal is to provide essential neurophysiological data where and how Ritalin affect different brain areas known to be the site of psychostimulant action and to understand the mechanism of methylphenidate (Ritalin) action in the brain using freely behaving adolescent, young adult and older rats previously implanted with a permanent electrode, i.e. animals without the anesthetic interfering in 5 brain areas suggested to be the brain sites where psychostimulant acts. These data are essential to understand how Ritalin affect the brain and will be beneficial to the ADHD patient and psychostimulant drug abusers in general.",27222,ZRG1,Special Emphasis Panel,,2,322204,
7755026,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC000105-35,,NIDCD:405273;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PORTLAND,UNITED STATES,OTOLARYNGOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"NUTTALL, ALFRED L;",1875888;,5R01DC000105,05/01/1977,01/31/2013,"ADP-Ribosyltransferase (Polymerizing); Active Oxygen; Adhesion Molecule; Adventitial Cell; American; Apoplexy; Biochemical; Biochemical Pathway; Biogenesis; Blood Vessels; Blood flow; Blood leukocyte; Body Tissues; Cachectin; Cachectin-Tumor Necrosis Factor; Capillary; Capillary Endothelial Cell; Capillary, Unspecified; Cardiac infarction; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Death; Cell Function; Cell Process; Cell Signaling; Cell Wall; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chemicals; Chemistry; Clinical Treatment; Cochlea; Cochlear Organ; Cochlear structure; Corti Cell; Cortis Organ; Data; Death; Developed Countries; Developed Nations; Drugs; Dysfunction; Ear; Ear structure; Ear, Internal; Endogenous Nitrate Vasodilator; Endothelial Cell, Capillary; Endothelial Cells; Endothelium-Derived Relaxing Factor; Energy Expenditure; Energy Metabolism; Environment; Event; Functional disorder; Future; Goals; Hair Cells; Health; Hearing; Hearing Loss; Hearing Loss, Noise-Induced; Home; Home environment; Hypoacuses; Hypoacusis; Hypoxia; Hypoxic; IL-1; IL1; INFLM; Immunoglobulin Enhancer-Binding Protein; Industrialized Countries; Industrialized Nations; Inflammation; Inflammatory; Injury; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Ischemia; Ischemia-Reperfusion Injury; Job Environment; Job Location; Job Place; Job Setting; Job Site; Laboratories; Labyrinth; Lateral; Lead; Leisure Activities; Leukocytes; Link; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Marrow leukocyte; Mechanics; Medication; Membrane Channels; Metabolic; Metabolic Networks; Microcirculation; Mitochondria; Modeling; Molecular; Mononitrogen Monoxide; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardium; N element; N2 element; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; NF-kB; NF-kappa B; NF-kappaB; NFKB; Na element; National Institute on Deafness and Other Communication Disorders; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Noise; Noise-Induced Hearing Loss; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Organ of Corti; Organ of Corti structure; Origin of Life; Oxygen Deficiency; Oxygen Radicals; PARP Polymerase; PARS; Pathology; Pathway interactions; Pb element; Pericapillary Cell; Pericytes; Perivascular Cell; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiology; Physiopathology; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Population; Prevention; Pro-Oxidants; Process; Production; Reactive Oxygen Species; Receptor Protein; Recovery; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Research; Reticuloendothelial System, Leukocytes; Risk; Role; Rouget Cells; Science of Chemistry; Sensory; Sensory Hair; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Sodium; Sound; Sound - physical agent; Spiral Organ; Spiral Organ of Corti; Stress; Stroke; Subcellular Process; T Helper Factor; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Time; Tissues; Transcription Factor NF-kB; Translational Research; Translational Research Enterprise; Translational Science; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Vascular Accident, Brain; Vascular Diseases; Vascular Disorder; Vascular Permeabilities; Vasodilating Agent; Vasodilator Agents; Vasodilator Drugs; Vasodilators; White Blood Cells; White Cell; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; base; biological signal transduction; biological systems; blood vessel disorder; brain attack; capillary; cardiac infarct; cardiac muscle; cell adhesion protein; cell damage; cell injury; cerebral vascular accident; coronary attack; coronary infarct; coronary infarction; drug/agent; ear hair cell; endothelial cell derived relaxing factor; health economics; hearing impairment; hearing perception; heart attack; heart infarct; heart infarction; heart muscle; heavy metal Pb; heavy metal lead; inner ear; interest; kappa B Enhancer Binding Protein; lymphocyte activating factor; mitochondrial; necrocytosis; nuclear factor kappa beta; pathophysiology; pathway; poly ADP polymerase; poly ADP ribose synthetase; public health relevance; receptor; reperfusion; response; social role; sound; sound perception; stem; stroke; transcription factor; translation research enterprise; trial regimen; trial treatment; tumor necrosis factor (unspecified); vascular; white blood cell; white blood corpuscle; work environment; work setting",Control of Inner Ear Microcirculation,,105,AUD,Auditory System Study Section,,35,405273,
7755396,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC000141-32,,NIDCD:530854;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PORTLAND,UNITED STATES,OTOLARYNGOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"NUTTALL, ALFRED L;",1875888;,5R01DC000141,04/01/1979,01/31/2012,"Acoustic; Acoustics; Amplifiers; Apical; Auditory Canal, External; Basilar Membrane; Blood Coagulation Factor IV; Body Tissues; Ca++ element; Calcium; Cavia; Cell Components; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Structure; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Structures; Chloride; Chloride Ion; Chlorides; Cl- element; Coagulation Factor IV; Cochlea; Cochlear Organ; Cochlear structure; Complex; Corti Cell; Cortis Organ; Custom; Cytoplasmic Membrane; Data; Dependence; Doppler OCT; Ear; Ear Canal; Ear structure; Ear, Internal; Endolymph; Environment; External Acoustic Meatus; External auditory canal structure; Factor IV; Frequencies (time pattern); Frequency; Goals; Guinea Pigs; Hair; Hair Cells; Hair Cells, Inner; Hair Cells, Outer; Hearing; Inner Hair Cells; Instrumentation, Other; Interferometry; Investigators; Knowledge; Laboratories; Labyrinth; Lateral; Learning; Locomotor Activity; Mammals, Guinea Pigs; Maps; Math Models; Measurement; Measures; Mechanics; Membrane; Modeling; Motility; Motility, Cellular; Motion; Motor; Motor Activity; Movement; OCT Tomography; Optical Coherence Tomography; Optics; Organ; Organ of Corti; Organ of Corti structure; Otoacoustic Emissions, Spontaneous; Outer Hair Cell of the Organ of the Corti; Outer Hair Cells; Pattern; Phase; Physiology; Plasma Membrane; Preparation; Pres protein, rat; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Receptor Protein; Relative; Relative (related person); Research Personnel; Researchers; Role; Solutions; Sound; Sound - physical agent; Speech; Speed; Speed (motion); Spiral Organ; Spiral Organ of Corti; Spontaneous Otoacoustic Emissions; Stereocilium; Stereovillus; Structure; Subcellular Process; System; System, LOINC Axis 4; Technology; Testing; Tissues; Tomography, Optical Coherence; V (voltage); Vibration; Vibration - physical agent; Work; base; body movement; cell motility; design; designing; driving force; ear hair cell; electrical property; experiment; experimental research; experimental study; extracellular; hearing perception; in vivo; inner ear; instrumentation; mathematical model; mathematical modeling; membrane structure; otoacoustic emission; plasmalemma; prestin; prestin (motor protein), rat; prestin protein, rat; programs; rat Pres protein; receptor; research study; response; social role; sound; sound perception; theories; vibration; voltage",Efferent Influence on Cochlear Mechanoelectric Physiology,,141,AUD,Auditory System Study Section,,32,530854,
7755027,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC000235-23,,NIDCD:254133;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOSTON,UNITED STATES,,09,073825945,US,MA,021143096,MASSACHUSETTS EYE AND EAR INFIRMARY,"GUINAN, JOHN J;",1902823;,5R01DC000235,06/01/1984,01/31/2013,"Acoustic Nerve; Affect; Animals; Apical; Area; Au element; Basilar Membrane; Cats; Cavia; Cell Locomotion; Cell Migration; Cell Movement; Cellular Migration; Chinchilla; Chinchilla (genus); Circulatory Collapse; Cochlea; Cochlear Organ; Cochlear structure; Code; Coding System; Cortis Organ; Cranial Nerve Eight; Cranial Nerve VIII; Diagnosis; Domestic Cats; Eighth Cranial Nerve; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Frequencies (time pattern); Frequency; Generalized Growth; Gold; Growth; Guinea Pigs; Hair Cells, Outer; Hearing; Hereditary; Human; Human, General; In Vitro; Inherited; Learning; Life; Lobe; Mammals, Cats; Mammals, Guinea Pigs; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanics; Medial; Metric; Modeling; Motility; Motility, Cellular; Motion; Nerve Fibers; Nervous; Organ of Corti; Organ of Corti structure; Outer Hair Cells; Pathology; Pattern; Physical condensation; Physiology; Play; Property; Property, LOINC Axis 2; Radial; Research; Role; Shapes; Shock; Side; Sound; Sound - physical agent; Speech; Spiral Organ; Spiral Organ of Corti; Stereocilium; Stereovillus; Structure; Structure of tectorial membrane; System; System, LOINC Axis 4; Tail; Tectorial Membrane; Testing; Tissue Growth; Travel; VIIIth Cranial Nerve; Vestibulocochlear Nerve; Vibration; Vibration - physical agent; Work; auditory nerve; base; cell motility; circulatory shock; condensation; experiment; experimental research; experimental study; hearing perception; in vivo; insight; neural; ontogeny; relating to nervous system; research study; response; social role; sound; sound perception; tectorial membrane; vibration",Olivocochlear Efferent Systems and Cochlear Physiology,,235,AUD,Auditory System Study Section,,23,254133,
7760648,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC000407-23,,NIDCD:294148;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHARLOTTESVILLE,UNITED STATES,PSYCHOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"HILL, DAVID L;",1887789;,5R01DC000407,08/01/1986,01/31/2012,"21+ years old; Adult; Affect; Age; Behavior; Behavioral; Brain; Brain Stem; Brainstem; CNS plasticity; Cell Nucleus; Characteristics; Chorda Tympani Nerve; Common Rat Strains; Data; Development; Developmental Process; Diet; Dietary Sodium; Electrons; Encephalon; Encephalons; Event; Freezing; Generalized Growth; Goals; Growth; Gustation; Human, Adult; Laboratories; Learning; Life; Mammals, Rats; Measures; Microscopic; Na element; Negative Beta Particle; Negatrons; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Nucleus; Nucleus Tractus Solitarii; Nucleus solitarius; Pathway interactions; Peripheral; Phase; Physiologic; Physiological; Process; Property; Property, LOINC Axis 2; Rat; Rattus; Recovery; Resolution; Role; Saccharose; Science of neurophysiology; Shapes; Sodium; Sodium, Dietary; Solitary Nucleus; Staging; Stimulus; Structure; Structure of chorda tympani; Sucrose; Synapses; Synaptic; System; System, LOINC Axis 4; Taste; Taste Perception; Testing; Tissue Growth; adult human (21+); adult youth; age dependent; age related; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; chorda tympani; density; driving behavior; experiment; experimental research; experimental study; glossopharyngeal; neural; neural plasticity; neuronal; neurophysiology; neuroplasticity; ontogeny; pathway; postnatal; preference; receptive field; relating to nervous system; research study; response; social role; solitary tract nucleus; young adult",Ontogeny of Central Neural Taste Responses,,407,SCS,Somatosensory and Chemosensory Systems Study Section,,23,294148,
7738908,R01,DC,5,,12/01/2009,11/30/2010,,5R01DC000436-22,,NIDCD:315563;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,COLLEGE PARK,UNITED STATES,BIOLOGY,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"CARR, CATHERINE EMILY;",1905367;,5R01DC000436,02/01/1988,11/30/2012,"21+ years old; Acoustic Nerve; Adaptation, Physiological; Adaptations, Physiologic; Address; Adult; Advocate; Auditory; Auditory Localization; Auditory system; Aves; Avian; Axon; Barn Owls; Birds; Brain; Brain Stem; Brainstem; Cell Nucleus; Cells; Chickens; Cochlear Nucleus; Cochlear nucleus structure; Code; Coding System; Contralateral; Cranial Nerve Eight; Cranial Nerve VIII; Data; Detection; Development; Ear; Ear structure; Eighth Cranial Nerve; Encephalon; Encephalons; Evolution; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Genes; Grant; Head; Human, Adult; In Vitro; Individual; Investigators; Ipsilateral; Knowledge; Label; Light; Location; Mammalia; Mammals; Mammals, General; Maps; Measures; Modeling; Morphology; Msec; Myelin; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nucleus; Owls; Phase; Photoradiation; Physiologic; Physiological; Physiological Adaptation; Physiology; Population; Process; Racial Segregation; Regulation; Reptiles; Reptilia; Research Personnel; Researchers; Role; Solutions; Sound; Sound - physical agent; Sound Localization; Stream; Strigiformes; Structure; Study models; Synaptic plasticity; Testing; Time; Trees; VIIIth Cranial Nerve; Vestibulocochlear Nerve; adult human (21+); auditory nerve; auditory stimulus; detector; improved; in vivo; millisecond; myelination; neural; neural circuit; neural circuitry; neuronal; population based; relating to nervous system; response; segregation; social role; sound; sound frequency; theories",Cellular Mechanisms Underlying Sound Localization,,436,AUD,Auditory System Study Section,,22,315563,
7755029,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC001065-18,,NIDCD:314526;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,DURHAM,UNITED STATES,BIOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"SIMON, SIDNEY A;",1867773;,5R01DC001065,04/01/1991,01/31/2011,"Address; Affect; Algorithms; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Appetite; Area; Arts; Behavior; Brain; CCK; Cell Communication and Signaling; Cell Signaling; Cholecystokinin; Classification; Common Rat Strains; Complex; Consummatory Behavior; Country; Desire for food; Eating; Electrodes, Implanted; Electrodes, Miniaturized; Encephalon; Encephalons; Enhancers; Epidemic; Evolution; Exhibits; Feeding behaviors; Food; Food Intake; Goals; Gustation; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Hunger; Hypothalamic structure; Hypothalamus; Implant; Implanted Electrodes; Ingestive Behavior; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Ixodida; Knowledge; L-Glutamic acid, monosodium salt; Lateral; Leptin; Liquid substance; MSG; Mammals, Rats; Measures; Methods; Microelectrodes; Monosodium Glutamate; Motivation; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptide Tyrosine; Nutritional; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Organism; Pancreozymin; Pattern; Peptides; Physiologic; Physiological; Population; Preparation; Process; Programs (PT); Programs [Publication Type]; Public Health; Rat; Rattus; Research Personnel; Researchers; Rewards; Saccharose; Satiation; Satiations; Signal Transduction; Signal Transduction Systems; Signaling; Sodium Glutamate; Solutions; Source; Stimulus; Sucrose; Systematics; Taste; Taste Perception; Technology; Testing; Ticks; Uropancreozymin; adiposity; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; amygdaloid nuclear complex; biological signal transduction; corpulence; corpulency; corpulentia; drinking; feeding; feeding-related behaviors; fluid; ghrelin; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; liquid; living system; neural; neuronal; neuropeptide Y; novel; nutrient intake activity; ob/ob mouse; obese; obese people; obese person; obese population; orexin; orexin A; programs; public health medicine (field); relating to nervous system; response; reward circuitry; satiety",Gustatory Processing and Satiety,,1065,SCS,Somatosensory and Chemosensory Systems Study Section,,18,314526,
7769867,R01,DC,5,,03/01/2010,02/28/2011,,5R01DC004785-09,,NIDCD:298282;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,TALLAHASSEE,UNITED STATES,SOCIAL SCIENCES,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"CONTRERAS, ROBERT JOHN;",1892346;,5R01DC004785,03/20/2001,02/29/2012,"Address; Aldosterone; Altered Taste; Amiloride; Appetite; Behavior; Behavioral; Cells; Code; Coding System; Common Rat Strains; Desire for food; Detection; Dietary Fats; Dietary Sodium; Dimensions; Dodecanoic Acids; Electrophysiology; Electrophysiology (science); Esthesia; Extinction; Extinction (Psychology); Facial Nerve Ganglion; Fats; Fatty Acids, Nonesterified; Fatty acid glycerol esters; Flavoring; Flavoring Agents; Food Selections; Free Fatty Acids; Funding; Generalization, Stimulus; Genicular Ganglion; Geniculate Ganglion; Grant; Gustation; Hormonal; Human; Human, General; Hydrogen Oxide; Ingestion; Intake; Investigators; Lauric Acids; Link; Linoleic Acids; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Method LOINC Axis 6; Methodology; Methods; Na element; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Nonesterified Fatty Acids; Peripheral; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Process; Programs (PT); Programs [Publication Type]; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-; Rat; Rattus; Research; Research Personnel; Researchers; Role; Selections, Food; Sensation; Sensory; Sensory Process; Sodium; Sodium Chloride; Sodium chloride (NaCl); Sodium, Dietary; Solutions; Stimulus; Stimulus Generalization; Structure of geniculate ganglion; System; System, LOINC Axis 4; Taste; Taste Perception; Temperature; Testing; Time; Training; Water; Work; base; behavior test; behavioral extinction; behavioral test; deprivation; dietary lipid; experiment; experimental research; experimental study; functional group; in vivo; information processing; neural; neuronal; programs; psycho-physiological; relating to nervous system; research study; response; salt; salt intake; sensory system; social role",Neural Taste and Thermal Coding in Geniculate Ganglion,,4785,ZRG1,Special Emphasis Panel,,9,298282,
7755019,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC005216-10,,NIDCD:297744;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,MINNEAPOLIS,UNITED STATES,PSYCHOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"OXENHAM, ANDREW J;",2101049;,5R01DC005216,02/15/2002,01/31/2012,"Accounting; Acoustic; Acoustics; Algorithms; Analysis, Data; Auditory Prosthesis; Auditory system; Behavioral; Cochlear Implants; Cochlear Prosthesis; Code; Coding System; Cognitive Discrimination; Complex; Computer Simulation; Computerized Models; Data Analyses; Detection; Development; Difference Limen; Differential Threshold; Discrimination; Discrimination (Psychology); Ear; Ear structure; Electric Stimulation; Electrical Stimulation; Environment; Frequencies (time pattern); Frequency; Goals; Grouping; Hearing; Hearing Loss, Sensorineural; Human; Human, General; Individual; Investigators; Life; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Music; Musics; Noise; Perception; Performance; Peripheral; Pitch Discrimination; Pitch Perception; Play; Predisposition; Process; Programs (PT); Programs [Publication Type]; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Racial Segregation; Research; Research Personnel; Researchers; Residual; Residual state; Resolution; Role; Running; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Simulation, Computer based; Sound; Sound - physical agent; Source; Speech; Stimulus; Structure; Susceptibility; System; System, LOINC Axis 4; Techniques; Testing; Voice; Work; base; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; experience; experiment; experimental research; experimental study; groupings; hearing perception; improved; in silico; musician; programs; psycho-physiological; research study; segregation; simulation; social role; sound; sound perception; speech recognition; standard measure; virtual simulation",Complex Pitch Perception in Complex Environments,,5216,AUD,Auditory System Study Section,,10,297744,
7764763,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC005811-07,,NIDCD:278327;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,AUGUSTA,UNITED STATES,NEUROLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"MCCLUSKEY, LYNNETTE MARIE;",7047847;,5R01DC005811,12/01/2002,01/31/2014,"21+ years old; Accounting; Adult; Affect; Amiloride; Animal Feed; Anterior; Apoptosis; Apoptosis Pathway; Arrowhead; Award; Bilateral; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; CD106; CD106 Antigens; Cell Communication; Cell Death, Programmed; Cell Function; Cell Interaction; Cell Process; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chorda Tympani Nerve; Common Rat Strains; Contralateral; Diet; Dietary Sodium; ENaC; ENaC (epithelial Na+ channel); Edodekin Alfa; Epithelial; Equilibrium; Figs; Figs - dietary; Functional Imaging; Gray; Gray unit of radiation dose; Gustation; Heterophil Granulocyte; Human, Adult; IL-1 inhibitor, urine; IL-12; IL-1ra; IL1 febrile inhibitor; IL12; IL1RN; INCAM-110; Immune; Immune response; Immune system; Inducible Cell Adhesion Molecule 110; Injury; Interleukin-1 Receptor Antagonist; Interleukin-12; Interleukins; Ion Channels, Sodium; Lead; Left; Leukocytes; Mammals, Rats; Maps; Marrow Neutrophil; Marrow leukocyte; Mediating; NKSF; Na element; Natural Killer Cell Stimulatory Factor; Natural regeneration; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neuroreceptors; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pb element; Peripheral nerve injury; Physiologic Imaging; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Proteins; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-; Rat; Rattus; Receptor Cell; Receptor Protein; Receptors, Neural; Receptors, Sensory; Recruitment Activity; Regeneration; Resolution; Reticuloendothelial System, Leukocytes; Right-On; Role; Sagittaria; Science of neurophysiology; Sensory; Sensory Receptors; Side; Site; Sodium; Sodium Channel; Sodium, Dietary; Stimulus; Structure of chorda tympani; Subcellular Process; System; System, LOINC Axis 4; Taste; Taste Buds; Taste Perception; Testing; Tongue; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; White Blood Cells; White Cell; Work; adult human (21+); afferent nerve; anakinra; animal food; balance; balance function; body system, allergic/immunologic; chorda tympani; cytokine; epithelial Na+ channel; feeding; gene product; heavy metal Pb; heavy metal lead; host response; immunoresponse; in vivo; injured; injury response; interleukin 1 inhibitor, urine; interleukin 1 receptor antagonist protein; macrophage; nerve injury; neural; neural injury; neuronal; neurophysiology; neutrophil; organ system, allergic/immunologic; prevent; preventing; public health relevance; receptor; recruit; regenerate; relating to nervous system; response; response to injury; sensory nerve; social role; unspecified interleukin; urine-derived IL1 inhibitor; white blood cell; white blood corpuscle",Degenerative changes in the taste system," PROJECT NARRATIVE The immune system plays an important role following neural injury, but its response to degeneration in the taste system is not well-understood. The proposed studies will determine the effects of an imbalanced immune response on taste function, and the mechanisms for immune-taste receptor cell interactions. Better understanding of the beneficial and harmful effects of the immune response to injury will lead to new strategies to promote normal sensory function.",5811,SCS,Somatosensory and Chemosensory Systems Study Section,,7,278327,
7771706,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC005960-05,,NIDCD:334385;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,STANFORD,UNITED STATES,ENGINEERING (ALL TYPES),14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"STEELE, CHARLES RICHARD;",1892335;,5R01DC005960,02/17/2009,01/31/2014,"3-D; 3-Dimensional; Acoustic; Acoustics; Affect; Air; Animals; Articulation; Auditory Localization; Biomechanics; Bone; Bone Conduction; Bone and Bones; Bones and Bone Tissue; Cartilage; Cartilagenous Tissue; Characteristics; Clinical; Cochlea; Cochlear Organ; Cochlear structure; Collagen Fiber; Complex; Computer Simulation; Computerized Models; Coupling; Cues; Ear; Ear structure; Eardrum; Electromagnetic, Laser; Electron Microscopy; Elements; Fascia; Fiber; Foundations; Frequencies (time pattern); Frequency; Generations; Goals; Grant; Hearing; Human; Human, General; Image; Incus; Incus structure; Joints; Knowledge; Lasers; Lead; Malleus; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Membrana Tympanica; Methods; Microscopy; Modeling; Models, Computer; Motion; Muscle; Muscle Tissue; Myringoplasty; Noise; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Otoacoustic Emissions, Spontaneous; Otologic Surgical Procedures; Outcome; Patients; Pb element; Persons; Physics; Physiologic; Physiological; Physiology; Play; Procedures; Process; Prosthesis; Prosthetic device; Prosthetics; Radial; Radiation, Laser; Research; Role; Shapes; Simulation, Computer based; Solid; Sound; Sound - physical agent; Sound Localization; Speech; Speech Perception; Spontaneous Otoacoustic Emissions; Stapedius; Stapedius Muscle; Stapes; Structure; Structure of stapedius muscle; Structure of tensor tympani muscle; Structure-Activity Relationship; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; TEM; Temporal Bone; Temporal bone structure; Tensor Tympani; Testing; Thinking; Thinking, function; Transducers; Transmission; Transmission Electron Microscopy; Tympanic Membrane; Tympanic membrane structure; Tympanoplasty; Tympanus, Tensor; Vertebrate Animals; Vertebrates; aural muscle; base; bone; bone conduction hearing; chemical structure function; clinical applicability; clinical application; computational framework; computational modeling; computational models; computational simulation; computer based models; computer framework; computerized modeling; computerized simulation; cryogenics; ear drum; ear muscle; ear surgery; expectation; experiment; experimental research; experimental study; hearing perception; heavy metal Pb; heavy metal lead; imaging; improved; in silico; middle ear; morphometry; multi-photon; otoacoustic emission; reconstruction; repair; repaired; research study; response; restoration; second harmonic; social role; sound; sound frequency; sound perception; stapedius muscle; structure function relationship; surgery; tensor tympani muscle; transmission process; vertebrata; virtual; virtual simulation","Human middle-ear imaging, physiology, and biomechanics","  Project Narrative While it is well accepted that amongst terrestrial vertebrates, the mammalian middle ear is unique in its ability to transmit sounds from the external world to the cochlea for frequencies above 10 kHz, the biomechanical basis for sound transmission at high frequencies is poorly understood, which has consequences in the clinical realm. It is well known that the morphometry of the middle ear plays a key role in sound transmission, but the lack of knowledge about the relationships between middle-ear structures and sound transmission has resulted in unsatisfactory and variable outcomes of middle-ear repairs, particularly at high frequencies where sound localization cues may be important for hearing in noisy situations. The proposed studies will provide a solid scientific foundation for understanding the structural basis of middle-ear sound transmission, leading to clinical applications for the surgical reconstruction of the middle ear, the interpretation of otoacoustic emissions, and improvements to the understanding of passive and active prostheses used by surgeons to repair the middle ear.",5960,AUD,Auditory System Study Section,,5,334385,
7752836,R01,DC,5,,01/01/2010,12/31/2010,PA-07-070,5R01DC006473-07,,NIDCD:357917;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LA JOLLA,UNITED STATES,OTHER HEALTH PROFESSIONS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"PADDEN, CAROL ;",7596614;,5R01DC006473,01/27/2004,12/31/2013,"0-11 years old; Age; Age Group Unspecified; American Sign Language; Attention; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Back; Bedouin; Categories; Cell Communication and Signaling; Cell Signaling; Cereals; Cerebral Palsy; Child; Child Youth; Children (0-21); Code; Coding System; Collaborations; Communication; Communities; Complement; Complement Proteins; Complex; Computer Simulation; Computerized Models; Deaf; Development; Documentation; Dorsum; Elements; Environment; Evolution; Family; Funding; Generations; Grain; Hard of Hearing Persons; Health; Hearing; Hearing Impaired Persons; Household; Human; Human, Child; Human, General; Individual; Intracellular Communication and Signaling; Investigation; Investigators; Israel; Judgment; Kanner's Syndrome; Laboratories; Language; Learning; Linguistic; Linguistics; Man (Taxonomy); Man, Modern; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Methods; Modeling; Models, Computer; Morphology; Names; Nature; Oral; Pattern; Perception; Persons With Hearing Impairments; Phrases (PT); Phrases [Publication Type]; Production; Property; Property, LOINC Axis 2; Psychologist; Research; Research Personnel; Researchers; Sign Language; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; Staging; Structure; System; System, LOINC Axis 4; Testing; Time; Transmission; Universities; Videotape; Vocabulary; Vocabulary Words; Work; Writing; age group; aged; base; biological signal transduction; children; cohort; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; density; design; designing; experiment; experimental research; experimental study; feeding; hearing perception; in silico; innovate; innovation; innovative; insight; interest; intervention program; model design; natural language; next generation; novel; phonological; phonology; phrases; public health relevance; research study; self organization; social; sound perception; syntactic; syntax; time use; tool; transmission process; virtual simulation; youngster",Emergence of Grammar in a New Sign Language,,6473,LCOM,Language and Communication Study Section,,7,357917,
7747961,R01,DC,5,,01/01/2010,12/31/2010,,5R01DC006483-05,,NIDCD:335173;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ATLANTA,UNITED STATES,OTOLARYNGOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"LIN, XI ;",1898504;,5R01DC006483,01/15/2006,12/31/2010,"3'5'-cyclic ester of AMP; 5-Oxazolecarboxylic acid, 2-(6-(bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-; A Mouse; Action Potentials; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Assay; Autoregulation; BACs (Chromosomes); Bacterial Artificial Chromosomes; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Chiro-Inositol; Cochlea; Cochlear Organ; Cochlear structure; Code; Coding System; Communicating Junction; Connexins; Cortis Organ; Coupling; Cyclic AMP; Data; Deaf; Deafness; Diffusion; EGFP protein; Electrical Synapse; Electrodes; Ethnic group; Fluorescence; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Fura-2; Future; Gap Junction Proteins; Gap Junctions; Genes; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Goals; Hard of Hearing Persons; Hearing; Hearing Impaired Persons; Hearing Loss; Hearing Loss, Sensorineural; Hearing Tests; Hereditary Disease; Homeostasis; Homo; Human; Human, General; Hypoacuses; Hypoacusis; Image; In Situ; In Vitro; Inositol; Investigators; Ion Exchange; Ions; Kinetic; Kinetics; Knock-out; Knockout; Knowledge; Link; Linkage (Genetics); Low-resistance Junction; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Mesoinositol; Mice; Mice, Transgenic; Molecular; Molecular Configuration; Molecular Conformation; Molecular Disease; Molecular Stereochemistry; Monitor; Murine; Mus; Mutation; Myocardial Contraction; Nexus; Nexus Junction; Nutrient; Organ of Corti; Organ of Corti structure; Paper; Patch-Clamp Technics; Patch-Clamp Techniques; Patients; Peptide Biosynthesis, Ribosomal; Permeability; Persons With Hearing Impairments; Physiological Homeostasis; Plasmids; Play; Preparation; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Family; Protein Synthesis, Ribosomal; Proteins; Publishing; Regulator Genes; Research Personnel; Researchers; Role; Saccharose; Sclera; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Series; Signaling Molecule; Spiral Organ; Spiral Organ of Corti; Sucrose; Surface Proteins; System; System, LOINC Axis 4; Testing; The Sun; Tissues; Transcriptional Regulatory Elements; Transfection; Transgenic Mice; Transgenic Organisms; White of Eye; adenosine 3'5' monophosphate; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; cAMP; conformation; conformational state; design; designing; effective therapy; enhanced green fluorescent protein; experiment; experimental research; experimental study; fluorescent dye/probe; gap junction channel; gene product; genetic disorder; genetic linkage; genetic manipulation; genome mutation; genome, mouse; hearing impairment; hearing perception; heart contraction; hereditary disorder; imaging; improved; in vivo; intercellular communication; interdisciplinary approach; lens; membrane structure; mouse genome; mutant; programs; protein synthesis; reconstitute; reconstitution; regulatory gene; research study; response; social role; sound perception; trans acting element; transgenic",Role of connexins in cochlear functions,,6483,AUD,Auditory System Study Section,,5,335173,
7755028,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC006685-06,,NIDCD:349608;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,SALT LAKE CITY,UNITED STATES,BIOMEDICAL ENGINEERING,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"RABBITT, RICHARD D;",2104179;,5R01DC006685,05/01/2004,01/31/2013,"Acceleration; Accounting; Affect; Afferent Neurons; Aged 65 and Over; Benign paroxysmal positional nystagmus; Benign paroxysmal positional vertigo; Benign paroxysmal postural vertigo; Biomechanics; Brain; Calcium Carbonate; Carbonic acid calcium salt (1[{..}]1); Cell Body; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cellular Migration; Chelating Agents; Chelators; Cilia; Clinical; Cochlea; Cochlear Organ; Cochlear structure; Code; Coding System; Complexons; Corti Cell; Data; Dependence; Diagnosis; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Disease; Disorder; Duct; Duct (organ) structure; Elderly; Elderly, over 65; Electrical Impedance; Encephalon; Encephalons; Endolymph; Endolymphatic duct; Esthesia; Experimental Models; Experimental Models, Other; Force of Gravity; Frequencies (time pattern); Frequency; Funding; Goals; Gravities; Hair; Hair Cells; Hair Cells, Outer; Head; Head Movements; Health; Human; Human, General; Impedance; Intracellular Communication and Signaling; Knowledge; Lead; Light; Liquid substance; Location; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Modeling; Models, Experimental; Motility; Motility, Cellular; Motion; Movement; Nervous; Nervous System, Brain; Neurons, Afferent; Neurons, Sensory; Outer Hair Cells; Patients; Pb element; Phase; Photoradiation; Physicians; Physiologic; Physiological; Population; Pres protein, rat; Process; Role; Rotation; Semicircular Canals; Semicircular canal structure; Sensation; Sensory; Sensory Cell Afferent Neuron; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Swelling; System; System, LOINC Axis 4; Testing; Therapeutic; Time; V (voltage); Visit; Work; abstracting; advanced age; attenuation; benign parxysmal vertigo; biological signal transduction; body movement; cell body (neuron); cell motility; computerized data processing; data processing; design; designing; disease/disorder; ear hair cell; elders; electric field; electric impedance; experiment; experimental research; experimental study; feeding; fluid; geriatric; heavy metal Pb; heavy metal lead; improved; in vivo; late life; later life; liquid; neural; neural cell body; neuronal cell body; nystagmus, positional, labyrinthine; older adult; older person; particle; prestin; prestin (motor protein), rat; prestin protein, rat; rat Pres protein; relating to nervous system; research study; response; senior citizen; signal processing; social role; soma; vestibulopathy, familial; voltage",Biomechanics of the Semicircular Canals,,6685,ZRG1,Special Emphasis Panel,,6,349608,
7765548,R01,DC,5,,03/01/2010,02/28/2011,,5R01DC007194-05,,NIDCD:326631;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LEXINGTON,UNITED STATES,PHYSIOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"MCCLINTOCK, TIMOTHY S;",1887772;,5R01DC007194,03/01/2006,02/28/2011,"21+ years old; ACSL1; ANOVA; ASCL1; ASCL1 protein; ASCL1 protein, human; ASH1; Abbreviations; Abscission; Achaete-Scute Complex Homolog-Like 1 Protein; Achaete-Scute Complex-Like 1 Protein; Achaete-Scute Homolog 1 Protein; Adult; Affect; Afferent Neurons; Analysis of Variance; Animals; Axon; B-50 Protein; Basal Cell; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cessation of life; DNA Synthesis Factor; Data Set; Dataset; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Differentiation and Growth; ECGF; Embryo; Embryonic; Endothelial Cell Growth Factor; Epithelium, Olfactory; Erinaceidae; Excision; Extirpation; FGF; FISH Technic; FISH Technique; FISH analysis; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Fluorescent in Situ Hybridization; GAP-43; GAP-43 Protein; GAP43 Protein; GFP; Galactosidase; General Transcription Factor Gene; Genes; Genes, LacZ; Genomics; Green Fluorescent Proteins; Growth Associated Protein 43; HASH1 protein; HBGF; HTH DNA Binding Domain; HTH Motifs; Hedgehogs; Helix-Turn-Helix Motifs; Human Achaete-Scute Homolog 1 Protein; Human, Adult; In Situ Hybridization, Fluorescence; Intracellular Communication and Signaling; Investigators; Knockout Mice; LacZ; LacZ Genes; Life; Link; MASH 1 protein; MASH1; MASH1 protein; Mammalian Achaete-Scute Homolog 1; Mammals, Mice; Measures; Messenger RNA; Methods; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Mother Cells; Mouse Strains; Murine; Mus; Natural regeneration; Nerve Cells; Nerve Growth Cone Membrane Protein GAP-43; Nerve Unit; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Neural Cell; Neural Development; Neural Growth; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological Damage; Neurological Injury; Neurological trauma; Neuromodulin; Neuronal Growth; Neurons; Neurons, Afferent; Neurons, Sensory; Neurosciences Research; Null Mouse; Odor Receptor Protein; Odorant Receptors; Olfactory Bulb; Olfactory Epithelium; Olfactory Receptor Proteins; PCR; Pattern; Phosphoprotein B-50; Phosphoprotein F1; Phosphoprotein pp46; Play; Polymerase Chain Reaction; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Proto-Oncogene, Transcription Factor; RNA, Messenger; RT-PCR; RTPCR; Receptor Proteins, Odorant; Receptors, Odorant; Regeneration; Removal; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Reverse Transcription; Role; Sensory Cell Afferent Neuron; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Stem cells; Structure of olfactory bulb; Surgical Removal; Testing; Time; Transcript; Transcription Activation; Transcription factor genes; Transcriptional Activation; Trauma, Nervous System; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variance Analyses; Work; achaete-scute complex-like 1 (Drosophila) protein, human; adult human (21+); biological signal transduction; cell type; experiment; experimental research; experimental study; gene product; helix loop helix; helix turn helix; human ASCL1 protein; human achaete-scute homolog 1; interest; mRNA; mutant; neural growth associated protein; neurodegenerative illness; neurodevelopment; neurogenesis; neuron development; neuronal; null mutation; olfactory bulb; olfactory marker protein; postnatal; progenitor; programs; protein function; receptor expression; regenerate; research study; resection; response; reverse transcriptase PCR; social role; sustentacular cell; transcription factor",Genomic of Olfactory Regeneration,,7194,ZRG1,Special Emphasis Panel,,5,326631,
7755835,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC007395-03,,NIDCD:385877;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BALTIMORE,UNITED STATES,BIOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ZHAO, HAIQING ;",7270670;,5R01DC007395,02/27/2008,01/31/2013,"3'5'-cyclic ester of AMP; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Afferent Neurons; Animal Behavior; Animal Model; Animal Models and Related Studies; Animals; Behavior; Behavior, Animal; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Brain; CNG channel (rod); Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Cilia; Cognitive Discrimination; Combining Site; Cyclic AMP; Cyclic Nucleotides; Detection; Discrimination; Discrimination (Psychology); Dysfunction; Encephalon; Encephalons; Enzymes; Feedback; Functional disorder; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Genetic Alteration; Genetic Change; Genetic defect; Goals; In Vitro; Individual; Intracellular Communication and Signaling; Investigation; Kinetic; Kinetics; Knockout Mice; Knowledge; Lead; Mammals, Mice; Mediating; Membrane Potentials; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mouse Strains; Murine; Mus; Mutation; Nervous System, Brain; Neurons, Afferent; Neurons, Sensory; Nucleotides, Cyclic; Null Mouse; Odors; Olfaction; Olfactions; PDE; Partner in relationship; Pathway interactions; Pb element; Perception; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphodiesterases; Physiologic; Physiological; Physiology; Physiopathology; Play; Process; Property; Property, LOINC Axis 2; Proteins; Reactive Site; Regulation; Research; Resting Potentials; Role; Sensory; Sensory Cell Afferent Neuron; Signal Transduction; Signal Transduction Systems; Signaling; Smell; Smell Perception; Social Interaction; System; System, LOINC Axis 4; Testing; Time; Transmembrane Potentials; adenosine 3'5' monophosphate; biological signal transduction; cAMP; cationic channel protein (rod); cyclic-nucleotide gated channel; cyclic-nucleotide gated ion channels; experiment; experimental research; experimental study; feeding; gene product; genome mutation; heavy metal Pb; heavy metal lead; in vivo; insight; mate; model organism; mouse model; pathophysiology; pathway; phosphoric diester hydrolase; research study; response; role model; sensory system; social role",Regulation of Olfactory Signal Transduction,,7395,SCS,Somatosensory and Chemosensory Systems Study Section,,3,385877,
7761219,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC007893-05,,NIDCD:384184;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,SANTA BARBARA,UNITED STATES,NONE,23,094878394,US,CA,93106,UNIVERSITY OF CALIFORNIA SANTA BARBARA,"INGHAM, ROGER J;",1871783;,5R01DC007893,02/01/2006,01/31/2011,"21+ years old; Active Follow-up; Address; Adult; Adult Stuttering; Affective; Behavior; Behavioral; Behavioral Model; Biological Models; Brain imaging; Cerebrovascular Circulation; Clinic; Clinical Trial Overviews; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Cognitive; Computers; Data; Data Pooling; Data Poolings; Development; Developmental Stuttering; Enrollment; Evaluation; Female; Frequencies (time pattern); Frequency; Goals; Human, Adult; Image; Investigators; Knowledge; Maintenance; Maintenances; Measurement; Measures; Medical Imaging, Positron Emission Tomography; Meta-Analyses; Meta-Analysis; Model System; Modeling; Models, Biologic; Models, Neurological; Monitor; Motor; Nervous; Neurologic; Neurologic Models; Neurological; Neurological Models; Neurology; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Patient Self-Report; Pattern; Performance; Phase; Phase 2 Clinical Trials; Phase II Clinical Trials; Phonation; Positron Emission Tomography Scan; Positron-Emission Tomography; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Randomized Clinical Trials; Relative; Relative (related person); Reporting; Research; Research Design; Research Personnel; Researchers; Role; Science of neurophysiology; Self-Report; Severities; Specific qualifier value; Specified; Speech; Study Type; Stuttering; System; System, LOINC Axis 4; Testing; Time; To specify; Training; Treatment Efficacy; Treatment outcome; Trials, Randomized Clinical; Work; adult human (21+); base; brain visualization; cerebral blood flow; cerebral circulation; cerebrocirculation; clinical investigation; comparative efficacy; design; designing; effective therapy; enroll; follow-up; imaging; improved; innovate; innovation; innovative; instrument; male; meetings; neural; neurophysiology; phase 2 study; phase 2 trial; phase II trial; programs; protocol, phase II; relating to nervous system; social role; standard of care; study design; study, phase II; stuttering therapy; theories; therapeutic efficacy; therapeutically effective; treatment effect; treatment program; treatment trial",Stuttering Therapy and Neurophysiological Interaction,,7893,MFSR,"Motor Function, Speech and Rehabilitation Study Section",,5,384184,
7755033,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC007905-05,,NIDCD:384105;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PITTSBURGH,UNITED STATES,OTOLARYNGOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"TZOUNOPOULOS, THANOS ;",6414978;,5R01DC007905,02/08/2007,01/31/2012,"Affect; Allergy; Assay; Auditory; Bioassay; Biologic Assays; Biological Assay; Biological Neural Networks; Brain Stem; Brainstem; CB1 Receptor; CNS plasticity; CaM KII; CaM PK II; CaM kinase II; CaMKII; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Nucleus; Cell Shape; Cell Signaling; Cells; Characteristics; Connector Neuron; Cues; Data; Dependence; Discrimination, Speech; Disease; Disorder; Dorsal Cochlear Nucleus; Electron Microscopy; Endocannabinoids; Equilibrium; Exhibits; Frequencies (time pattern); Frequency; Fusiform Cell; Generations; Glutamates; Goals; Hypersensitivity; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; L-Glutamate; Learning; Mediating; Metabolic Pathway; Methods and Techniques; Methods, Other; Modeling; Monitor; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Nucleus; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Output; Pattern; Presbycusis; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publishing; Receptor, Cannabinoid, CB1; Regulation; Relative; Relative (related person); Ringing-Buzzing-Tinnitus; Role; Scheme; Sensory; Sensory Process; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sound; Sound - physical agent; Specificity; Speech Discrimination; Structure; Structure of dorsal cochlear nucleus; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; Synaptic plasticity; Techniques; Time; Tinnitus; Whole-Cell Recordings; Work; age related hearing loss; balance; balance function; base; biological signal transduction; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cell type; computerized data processing; data processing; disease/disorder; experience; interest; neural; neural circuit; neural circuitry; neural network; neural plasticity; neuronal; neuroplasticity; novel; perceptual stimulus; physicochemical phenomena related to the senses; postsynaptic; programs; relating to nervous system; response; senile deafness; sensory gating; sensory integration; sensory stimulus; signal processing; social role; somatosensory; sound; surgery; ward",Cell-specific Synaptic Plasticity in the Auditory Brainstem,,7905,AUD,Auditory System Study Section,,5,384105,
7758725,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC007910-04,,NIDCD:257432;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,STANFORD,UNITED STATES,ENGINEERING (ALL TYPES),14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"STEELE, CHARLES RICHARD;",1892335;,5R01DC007910,02/05/2007,01/31/2011,"3D modeling; Acoustic; Acoustics; Affect; Air; Anatomic; Anatomical Sciences; Anatomy; Atomic Force Microscope; Atomic Force Microscopy; Basilar Membrane; Behavior; Biomechanics; Biophysics; Body Tissues; Bone; Bone Conduction; Bone and Bones; Bones and Bone Tissue; Cell Body; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Characteristics; Cilia; Clinic; Clinical; Cochlea; Cochlear Organ; Cochlear duct; Cochlear structure; Complement; Complement Proteins; Complex; Computer Simulation; Computerized Models; Confocal Microscopy; Corti Cell; Cortis Organ; Data; Development; Dimensions; Diseases of inner ear; Ductus Cochlearis; Ear; Ear structure; Electrical Impedance; Environment; Force Microscopy; Foundations; Frequencies (time pattern); Frequency; Future; Goals; Hair Cells; Hair Cells, Inner; Hair Cells, Outer; Health; Hearing; Impedance; In Vitro; Individual; Inner Ear Disorder; Inner Hair Cells; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Knowledge; Laboratories; Lead; Light; Link; Liquid substance; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Mechanics; Media, Scala; Membrane of Reissner; Methods; Microanatomy; Microscopic Anatomy; Microscopy, Atomic Force; Microscopy, Confocal; Modeling; Models, Computer; Motility; Motility, Cellular; Motion; Natural regeneration; Nervous; Noise; Organ of Corti; Organ of Corti structure; Oto/Rhino/Laryngology; Otolaryngology; Outcome; Outer Hair Cells; Pathologic; Pathology; Pathway interactions; Pb element; Photoradiation; Physiologic; Physiological; Physiology; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publishing; Receptor Protein; Regeneration; Reporting; Research; Research Personnel; Researchers; Resolution; Scala Medias; Scanning Force Microscopy; Science of Anatomy; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Solutions; Sound; Sound - physical agent; Spiral Organ; Spiral Organ of Corti; Stimulus; Structure; Structure-Activity Relationship; Subcellular Process; Testing; Therapeutic; Tissues; Transmission; Travel; Vestibular Apparatus; Vestibular membrane; Vestibule; Work; anatomy; base; biological signal transduction; bone; bone conduction hearing; cell body (neuron); cell motility; chemical structure function; computational framework; computational modeling; computational models; computational simulation; computer based models; computer framework; computerized modeling; computerized simulation; ear hair cell; electric impedance; fluid; genetic manipulation; hearing perception; heavy metal Pb; heavy metal lead; improved; in silico; in vivo; inner ear diseases; innovate; innovation; innovative; interventional strategy; liquid; middle ear; millimeter; nano mechanics; nano meter scale; nano meter sized; nano scale; nanomechanics; nanometer scale; nanometer sized; nanoscale; neural; neural cell body; neuronal cell body; otorhinolaryngology; pathway; physical model; pressure; prevent; preventing; programs; receptor; regenerate; relating to nervous system; response; soma; sound; sound perception; structure function relationship; theories; three-dimensional modeling; transmission process; virtual simulation",Three-dimensional and Multiscale Organ of Corti Biomechanics,,7910,AUD,Auditory System Study Section,,4,257432,
7755807,R01,DC,5,,02/01/2010,01/31/2011,PA-06-257,5R01DC008371-04,,NIDCD:262018;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,JACKSON,UNITED STATES,OTOLARYNGOLOGY,02,928824473,US,MS,39216,UNIVERSITY OF MISSISSIPPI MEDICAL CENTER,"SCHWEINFURTH, JOHN M;",8607933;,5R01DC008371,02/10/2007,01/31/2012,"21 year old; Address; Affect; African American; Afro American; Afroamerican; Age; Aging; Aging Process; Aging-Related Process; Alcohol Drinking; Alcohol consumption; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Apoplexy; Area; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atrophic; Atrophy; Audiogram; Audiometric Test; Audiometry; Audiometry, Pure-Tone; Autoregulation; BMI percentile; BMI z-score; Black Populations; Black or African American; Blinded; Blood Circulation; Blood Glucose; Blood Pressure; Blood Pressure, High; Blood Sugar; Blood Vessels; Bloodstream; Body mass index; Bone Conduction; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cardiovascular Diseases; Carotid Arteries; Causality; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Circulation; Clinical; Cochlea; Cochlear Organ; Cochlear structure; Cohort Studies; Communities; Concurrent Studies; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diabetes Mellitus; Diagnosis, Ultrasound; Diet; Disease; Disease Frequency Surveys; Disorder; Disorder of middle ear; Drugs; Dysfunction; Ear; Ear structure; Ear, Internal; Echography; Echotomography; Enrollment; EtOH drinking; Etiology; Evaluation; Event; Exhibits; Frequencies (time pattern); Frequency; Functional disorder; Goals; Grant; HDL; Hearing; Hearing Loss; Hearing Loss, Sensorineural; Heart; Heart Diseases; Heavy Lipoproteins; Hemoglobin; High Density Lipoproteins; High Prevalence; High density lipoprotein; History; Homeostasis; Hypertension; Hypertrophy, Left Ventricular; Hypoacuses; Hypoacusis; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Incidence; Individual; Investigators; Ischemia; Ischemic Stroke; Labyrinth; Left Ventricular Hypertrophy; Lipoproteins, HDL; Measurable; Measurement; Measures; Medical; Medical Imaging, Ultrasound; Medication; Microcirculation; Mississippi; Myocardial Infarct; Myocardial Infarction; Noise; Otoacoustic Emissions, Spontaneous; Otoscopy; Participant; Pathogenesis; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Physiopathology; Population; Presbycusis; Prevalence; Process; Prospective Studies; Protocol; Protocols documentation; Pure-Tone Audiometry; Questionnaires; Quetelet index; Recording of previous events; Recruitment Activity; Relative Risks; Research Personnel; Researchers; Risk; Risk Factors; Risks, Relative; SCHED; Schedule; Senescence; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Severities; Site; Smoking; Spontaneous Otoacoustic Emissions; Stria Vascularis; Stroke; Testing; Thick; Thickness; Trauma; Tympanometry; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Vascular Accident, Brain; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Woman; age dependent; age related; age related hearing loss; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; alpha-Lipoproteins; atheromatosis; atherosclerotic vascular disease; black American; blood vessel disorder; bone conduction hearing; brain attack; cardiac infarct; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cerebral vascular accident; clinical data repository; clinical data warehouse; clinical significance; clinically significant; cohort; coronary attack; coronary infarct; coronary infarction; data repository; diabetes; diagnostic ultrasound; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; enroll; epidemiologic data; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; hearing impairment; hearing perception; hearing screening; heart attack; heart disorder; heart infarct; heart infarction; hyperpiesia; hyperpiesis; hypertension treatment; hypertensive disease; inner ear; men; men's; metropolitan; middle ear disease; middle ear disorder; normal aging; otoacoustic emission; pathophysiology; population based; prospective; recruit; relational database; response; senescent; senile deafness; sex; sonogram; sonography; sound measurement; sound perception; speech recognition; stroke; twenty-one year old; ultrasound; ultrasound imaging; ultrasound scanning; vascular",Characterization of Hearing Status in the Jackson Heart Study Cohort,,8371,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,4,262018,
7759566,R01,DC,5,,02/01/2010,01/31/2011,PA-04-118,5R01DC008595-04,,NIDCD:376196;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PORTLAND,UNITED STATES,OTOLARYNGOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"BRIGANDE, JOHN VINCENT;",1974875;,5R01DC008595,02/01/2007,01/31/2012,"ALV related virus; Alkaline Phosphatase; Alpharetrovirus; Anterior; Auditory; Aves; Avian; Avian Leukosis Virus; Avian Leukosis-Sarcoma Viruses; Avian Retrovirus; Base Pairing; Birds; Carbocyanines; Cell Communication and Signaling; Cell Components; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Structure; CellLine; Cells; Cellular Structures; Coloring Agents; Complex; Corti Cell; Cortis Organ; Development; Developmental Gene; Dorsal; Dyes; Ear, Internal; Educational process of instructing; Electroporation; Embryo; Embryology; Embryology / Fetal Growth; Embryonic; Endolymphatic duct; Epithelial; Epithelium; Fiber Optics; Fibroblasts; Gene Expression; Gene Transfer; Gene Transfer Techniques; Gene, Developmental; GeneHomolog; Genetic; Genus Alpharetrovirus; Goals; HMG Box; HMG Domain; HMG-1 Domain; HMG-Box; Hair Cells; Hearing Loss; Heterogeneity; High Mobility Group Domain; Homolog; Homologous Gene; Homologue; Human; Human, General; Hypoacuses; Hypoacusis; In Situ; In Vitro; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Investigators; Knockout Mice; Label; Laboratories; Labyrinth; Lateral; Leukosis Virus, Avian; Libraries; MLV vector; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medial; Mediating; Medical; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Microinjections; Mitotic; Molecular; Molecular Probes; Morphogenesis; Mother Cells; Movement; Murine; Mus; Mutant Strains Mice; Null Mouse; Oligo; Oligonucleotides; Organ; Organ of Corti; Organ of Corti structure; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Otic Vesicle; Otoconias; Otoliths; Pattern; Pattern Formation; Plasmids; Position; Positioning Attribute; Progenitor Cells; Programs (PT); Programs [Publication Type]; Reagent; Receptors, Virus; Regulation; Research Personnel; Researchers; Retroviruses, ALV-Related; Role; Roller Bottle; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Spiral Organ; Spiral Organ of Corti; Staging; Statoconia; Statoconias; Stem cells; Structure of otoconia; Supporting Cell; System; System, LOINC Axis 4; Tag; Teaching; Testing; Time; Tracer; Transgenesis; Transgenic Mice; Type C Avian Retroviruses; Viral; Viral Receptor; Virus; Virus Receptors; Viruses, General; Wild Type Mouse; alkaline phosphomonoesterase; avian type C retrovirus group; biological signal transduction; body movement; cell fate specification; cultured cell line; ear hair cell; embryo culture; equilibration disorder; gain of function; glycerophosphatase; hearing impairment; in utero; in vivo; inner ear; insight; mammalian embryology; mouse mutant; murine leukemia retroviral vector; murine leukemia retrovirus vector; murine leukemia viral vector; murine leukemia virus vector; murine retroviral vector; murine retrovirus vector; mutant; otoconia; otocyst; otocyst/otolith; postnatal; progenitor; programs; receptor expression; regenerative; social role; tool; transcription factor; transfer of a gene; vector",Molecular Embryology of the Mammalian Inner Ear,,8595,AUD,Auditory System Study Section,,4,376196,
7755032,R01,DC,5,,02/01/2010,01/31/2011,,5R01DC008794-04,,NIDCD:314463;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"SHERMAN, S. MURRAY ;",2425258;,5R01DC008794,02/08/2007,01/31/2012,"Address; Adopted; Auditory; Auditory Cortex; Auditory Pathways; Auditory area; Auditory pathway structure; Auditory system; Automobile Driving; Axon; Brain; Cells; Cellular Morphology; Cognitive; Communication; Data; Depression; Dorsal; Drivings, Automobile; Electric Stimulation; Electrical Stimulation; Electromagnetic, Laser; Encephalon; Encephalons; Feedback; Glutamates; Goals; Hearing; In Vitro; Inferior Colliculus; Injection of therapeutic agent; Injections; Investigators; L-Glutamate; Label; Lasers; Lead; Leg; Mammals, Mice; Medial geniculate body; Mental Depression; Mesencephalon; Methods and Techniques; Methods, Other; Mice; Mid-brain; Midbrain; Midbrain structure; Murine; Mus; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Pathology; Pathway interactions; Pattern; Pb element; Physiologic pulse; Posterior Quadrigeminal Body; Preparation; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pulse; Radiation, Laser; Research; Research Personnel; Researchers; Role; Route; Selective inattention; Slice; Staging; Stream; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Testing; Thalamic structure; Thalamus; Visual System; Visual system structure; auditory pathway; biocytin; biotinyl L lysine; cell morphology; driving; electrical property; experiment; experimental research; experimental study; hearing perception; heavy metal Pb; heavy metal lead; information processing; lexical; neuronal; new approaches; novel approaches; novel strategies; novel strategy; object recognition; pathway; phonological; phonology; programs; research study; selective attention; semantic processing; sensory system; social role; somatosensory; sound perception; thalamic",Information processing in sensory systems,,8794,COG,Cognitive Neuroscience Study Section,,4,314463,
7755031,R01,DC,5,,02/01/2010,01/31/2011,PA-05-154,5R01DC008834-04,,NIDCD:286074;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,AURORA,UNITED STATES,PHARMACOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"JONES, DAVID NIGEL;",6630689;,5R01DC008834,03/24/2007,01/31/2012,"3-D structure; 3-dimensional structure; 3D structure; Address; Affinity; Alcohols; Amino Acid Substitution; Animals; Anopheles gambiae; Behavior; Behavioral; Binding; Binding (Molecular Function); Biological Function; Biological Process; Bite; Blood; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chemical Class, Alcohol; Chemicals; Communicable Diseases; Complex; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cues; Culicidae; Data; Death; Detection; Disease; Disorder; Drosophila melanogaster; Event; Feeds; Female; Foot; Goals; Hair; Human; Human, General; Incidence; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Insecta; Insects; Intracellular Communication and Signaling; Invertebrates, Insects; Investigators; Lead; Ligand Binding; Ligands; Location; Malaria; Man (Taxonomy); Man, Modern; Mediating; Methods; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecular Target; Mosquitoes; NMR Spectroscopy; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nuclear Magnetic Resonance; Odor Receptor Protein; Odorant Receptors; Odors; Olfactory Receptor Proteins; Organ; Paludism; Parasites; Pattern; Pb element; Perception; Pes; Pheromone; Plasmodium Infections; Plasmodium falciparum; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Trafficking; Proteins; Reagent; Receptor Activation; Receptor Protein; Receptor Proteins, Odorant; Receptors, Odorant; Research Personnel; Researchers; Reticuloendothelial System, Blood; Role; Series; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Skin; Specificity; Spectroscopy, NMR; Structure; Surface; Sweat; Sweating; System; System, LOINC Axis 4; Testing; Traffickings, Protein; Transmission; X Ray Crystallographies; X-Ray Crystallography; base; biological signal transduction; conformation; conformational state; d-Numb; design; designing; disease/disorder; feeding; foot; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; method development; neuronal; nuclear magnetic resonance spectroscopy; numb protein; odor-binding protein; odorant-binding protein; olfactory receptor; perspiration; programs; protein structure; protein transport; receptor; reproductive; response; social role; three dimensional structure; transmission process; vector transmission",Molecular basis of olfactory perception.,,8834,SCS,Somatosensory and Chemosensory Systems Study Section,,4,286074,
7755020,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009026-03,,NIDCD:324720;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BALTIMORE,UNITED STATES,OTOLARYNGOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"LANE, ANDREW P;",6613921;,5R01DC009026,02/01/2008,01/31/2011,"Acute; Address; Affect; Afferent Neurons; Animal Welfare; Animals; Area; Autoregulation; Basic Research; Basic Science; Bibliography; Blood Coagulation Factor IV; Blood leukocyte; Ca++ element; Cachectin; Cachectin-Tumor Necrosis Factor; Calcium; Cessation of life; Chronic; Cleaved cell; Clinical; Coagulation Factor IV; Country; Critiques; Data; Death; Dysfunction; EC 2.7.2-; Ecological impact; Environment; Environmental Impact; Epithelial; Epithelium; Epithelium, Olfactory; Equipment; Ethics Committees, Research; Extracellular Signal-Regulated Kinases; Factor IV; Foundations; Functional disorder; Histologic; Histologically; Homeostasis; Human; Human, General; IACUC; INFLM; IRBs; Impact, Environmental; Inflammation; Inflammation Mediators; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Lead; Left; Leukocytes; MAP kinase; MAPK; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Methods and Techniques; Methods, Other; Mice; Mitogen-Activated Protein Kinases; Modeling; Molecular; Morphology; Mosaicism; Mother Cells; Murine; Mus; Natural regeneration; Nature; Neural Growth; Neuronal Growth; Neurons, Afferent; Neurons, Sensory; Neurophysiology - biologic function; Obstruction; Olfaction; Olfactions; Olfactory Epithelium; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pattern; Pb element; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Principal Investigator; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Regeneration; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Leukocytes; Role; Scientist; Sensory Cell Afferent Neuron; Signal Pathway; Smell; Smell Perception; Stem cells; Stream; Structure; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; System; System, LOINC Axis 4; TNF-alpha; Techniques; Therapeutic; Translational Research; Translational Research Enterprise; Translational Science; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Vertebrate Animals; Vertebrates; White Blood Cells; White Cell; abstracting; apoptosis of neuronal cells; cell type; chronic rhinosinusitis; cleaved; cytokine; desensitization; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; human disease; human subject; innovate; innovation; innovative; insight; interest; mouse model; neural function; neuroepithelium; neurogenesis; neuron apoptosis; neuron cell death; neuron loss; neuronal apoptosis; neuronal cell death; neuronal loss; novel; novel therapeutic intervention; pathophysiology; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; regenerate; research study; response; social role; surgery; tool; transcription factor; translation research enterprise; vertebrata; white blood cell; white blood corpuscle",Chronic rhinosinusitis-associated olfactory loss,,9026,SCS,Somatosensory and Chemosensory Systems Study Section,,3,324720,
7742160,R01,DC,5,,02/01/2010,01/31/2011,DC-08-002,5R01DC009097-02,,NIDCD:388575;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"KALTENBACH, JAMES A;",1908263;,5R01DC009097,02/01/2009,01/31/2014,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Ablation; Abscission; Acetyl-CoA[{..}]choline O-acetyltransferase; Acetylcholine; Acetylcholine Antagonists; Acoustic Nerve; Acoustic Stimulation; Acute; Affect; Aminalon; Aminalone; Amino Acids; Aminoacetic Acid; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Area; Auditory; Auditory system; Brain; Brain Stem; Brainstem; Butanoic acid, 4-amino-; Causality; Cell Nucleus; Cells; Chemicals; Chemistry; Choline Acetylase; Choline Acetyltransferase; Choline O-Acetyltransferase; Cholinergic Antagonists; Cholinergic-Blocking Agents; Cholinolytics; Cochlear Nucleus; Cochlear nucleus structure; Complex; Contralateral; Control Animal; Cranial Nerve Eight; Cranial Nerve VIII; Cricetinae; Development; Dorsal Cochlear Nucleus; Drug usage; Eighth Cranial Nerve; Electric Stimulation; Electrical Stimulation; Electrodes, Miniaturized; Encephalon; Encephalons; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Etiology; Excision; Extirpation; Fusiform Cell; GABA; Generations; Glutamates; Glycine; Hamsters; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Inferior Colliculus; Ion Channel; Ionic Channels; Ions; Ipsilateral; L-Glutamate; Label; Lateral; Lesion; Maintenance; Maintenances; Mammals, Hamsters; Maps; Measures; Mediating; Membrane Channels; Methods; Methods and Techniques; Methods, Other; Microelectrodes; N-Ethyl-N-(4-pyridylmethyl)tropamide; N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Noise; Nucleus; Pathway interactions; Population; Posterior Quadrigeminal Body; Property; Property, LOINC Axis 2; Receptor Protein; Receptors, Synaptic; Relative; Relative (related person); Removal; Research; Ringing-Buzzing-Tinnitus; Role; Science of Chemistry; Site; Sound; Sound - physical agent; Stimulation, Auditory; Structure; Structure of dorsal cochlear nucleus; Structure of tractus olivocochlearis; Surgical Removal; Synaptic Receptors; Techniques; Testing; Time; Tinnitus; Translational Research; Translational Research Enterprise; Translational Science; Tropicamide; VIIIth Cranial Nerve; Vestibulocochlear Nerve; Work; aminoacid; amygdaloid nuclear complex; auditory nerve; auditory nuclei; base; cell type; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug use; effective therapy; enzyme activity; gamma-Aminobutyric Acid; neural; neuronal; olivocochlear bundle; pathway; prevent; preventing; receptor; receptor sensitivity; relating to nervous system; resection; response; social role; sound; translation research enterprise",Central auditory plasticity as a basis of tinnitus,,9097,ZDC1,Special Emphasis Panel,,2,388575,
7760647,R01,DC,5,,02/01/2010,01/31/2011,PA-07-127,5R01DC009236-03,,NIDCD:290998;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CLEMSON,UNITED STATES,BIOLOGY,03,042629816,US,SC,296345702,CLEMSON UNIVERSITY,"CHAPMAN, SUSAN CAROLINE;",8605481;,5R01DC009236,02/05/2008,01/31/2013,"0-6 weeks old; Affect; Animal Model; Animal Models and Related Studies; Animal Welfare; Aves; Avian; Bibliography; Binding; Binding (Molecular Function); Birds; Birth Defects; Body Tissues; Bone; Bone Spur; Bone and Bones; Bones and Bone Tissue; Candidate Disease Gene; Candidate Gene; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Chickens; Cholesteatoma; Chondrogenesis; Columella; Complex; Conductive Deafness; Conductive hearing loss; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Country; Defect; Development; Ear; Ear structure; Eardrum; Ecological impact; Embryo; Embryonic; Endoderm; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exostoses; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Expression; Gene Expression Profile; Genetics, in situ Hybridization; Glomus Neoplasm; Glomus Tumor; Goals; Hearing; Hearing Loss; Histology; Hypoacuses; Hypoacusis; IACUC; IRBs; Impact, Environmental; In Situ Hybridization; Infant, Newborn; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Membrana Tympanica; Methods; Modiolus; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Morphogenesis; Morphology; Names; Newborn Infant; Newborns; Otitis Media; Pattern; Physical condensation; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resources; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sound; Sound - physical agent; System; System, LOINC Axis 4; Time; Tissues; Transmission; Trauma; Tympanic Membrane; Tympanic membrane structure; Vertebrate Animals; Vertebrates; abstracting; biological signal transduction; bone; cell fate specification; condensation; ear drum; expiration; gene expression signature; hearing impairment; hearing perception; human subject; in situ Hybridization Staining Method; middle ear; model organism; newborn human (0-6 weeks); programs; social role; sound; sound perception; transcriptome; transmission process; vertebrata",Avian Middle Ear Development,,9236,AUD,Auditory System Study Section,,3,290998,
7763175,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009413-02,,NIDCD:399502;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"STOWERS, LISA T;",1896872;,5R01DC009413,02/01/2009,01/31/2014,"21+ years old; Adult; Afferent Neurons; Affinity Chromatography; Age; Aggression; Aggressive behavior; American; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Behavior; Behavioral; Behavioral Paradigm; Biochemical; Biochemistry; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Chemicals; Chemistry; Chemistry, Biological; Chromatography, Affinity; Coagulation Factor IV; Code; Coding System; Complement; Complement Proteins; Complex; Drugs; Dysfunction; Encephalon; Encephalons; Ensure; Environment; Epithelium, Olfactory; Expression Profiling; Expression Signature; Factor IV; Female; Functional disorder; Funding; Gender; Genetic; Genetics, in situ Hybridization; Goals; Hand; Histocytochemistry; Human; Human, Adult; Human, General; Hypothalamic structure; Hypothalamus; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Individual; Innate Behavior; Instinct; Intracellular Communication and Signaling; Investigation; Knowledge; Laboratories; Lead; Learning; Ligands; Link; Logic; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Mediating; Medication; Memory; Methods; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Molecular Analysis; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Murine; Mus; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Pathways; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology - biologic function; Neurosecretory Systems; Nucleus; Olfactory Epithelium; Outcome; Partner in relationship; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pheromone; Physiopathology; Plastics; Population; Position; Positioning Attribute; Receptor Protein; Regulation; Reporter; Research; Research Institute; Rodent; Rodentia; Rodentias; Science of Chemistry; Sensory Cell Afferent Neuron; Signal Transduction; Signal Transduction Systems; Signaling; Social Behavior; Societies; Stimulus; Swab; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Therapeutic Intervention; Urinary System, Urine; Urine; adult human (21+); affinity purification; amygdaloid nuclear complex; base; behavior test; behavioral test; biological signal transduction; design; designing; drug/agent; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; histochemistry; histochemistry/cytochemistry; hypothalamic; imaging; in situ Hybridization Staining Method; intervention therapy; male; mate; molecuar profile; molecular signature; mutant; neural; neural circuit; neural circuitry; neural function; neural information processing; neural mechanism; neuromechanism; neuronal; novel; pathophysiology; pathway; public health relevance; receptor; relating to nervous system; research study; response; small molecule; social; sociobehavior; sociobehavioral; tool",Identification of the ligands and sensory neurons that mediate pheromone behavior," Project Narrative In the mouse, sensory neurons that respond to pheromones activate nuclei in the medial amygdala and hypothalamus. These same nuclei have been implicated in regulating social behavior in humans. However, elucidation of the organization, functional significance, and specific mechanism of action of these centers is impeded by the lack of knowledge of the corresponding function of subsets of amygdala and hypothalamic neurons. We are defining components of the signals that elicit and regulate a known behavior. This important first step will allow us to predictably activate social responses in mice, and therefore define at the cellular and molecular level, the underlying mechanisms of neural function and dysfunction.",9413,SCS,Somatosensory and Chemosensory Systems Study Section,,2,399502,
7765520,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009417-02,,NIDCD:291464;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,MORGANTOWN,UNITED STATES,BIOLOGY,01,191510239,US,WV,265066845,WEST VIRGINIA UNIVERSITY,"DALY, KEVIN C;",6589253;,5R01DC009417,02/09/2009,01/31/2014,"Address; Affect; Area; Behavior; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Characteristics; Chemicals; Chemicals, Hazardous; Cognitive Discrimination; Crete; Data; Detection; Diagnosis; Diagnostic; Discrimination; Discrimination (Psychology); Dysfunction; Encephalon; Encephalons; Environment; Experimental Designs; Frequencies (time pattern); Frequency; Functional disorder; Generations; Goals; Hazardous Chemicals; Health; Human; Human, General; Insecta; Insects; Intracellular Communication and Signaling; Invertebrata; Invertebrates; Invertebrates, General; Invertebrates, Insects; Investigation; Knowledge; Lobe; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Mission; Modeling; Moths; Movement; Msec; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Odors; Olfaction; Olfactions; Organism; Perception; Physiologic; Physiologic pulse; Physiological; Physiology; Physiopathology; Play; Prevention; Prevention Measures; Process; Prophylactic treatment; Prophylaxis; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Public Health; Pulse; Receptor Protein; Relative; Relative (related person); Research; Resolution; Role; Safety; Sampling; Science of neurophysiology; Sensory; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Smell; Smell Perception; Stimulus; Structure; Synapses; Synaptic; System; System, LOINC Axis 4; Technology; Testing; Vertebrate Animals; Vertebrates; Wing; Work; base; behavior measurement; behavioral measure; behavioral measurement; biological signal transduction; biological systems; body movement; central pattern generator; computerized data processing; data processing; design; designing; detector; disease prevention; disorder prevention; experience; feeding; heuristics; human disease; in vivo; innovate; innovation; innovative; insight; living system; man; man's; millisecond; neural; neural mechanism; neurobehavior; neuromechanism; neuronal; neurophysiology; olfactory receptor; olfactory stimulus; pathophysiology; psycho-physiological; public health medicine (field); public health relevance; receptor; relating to nervous system; respiratory; response; sensor; sensory gating; signal processing; social role; vertebrata",The effect of periodic input on measures of olfactory processing and perception, The proposed studies are an important yet understudied area of olfaction that has the potential of elucidating optimal stimulus parameters for odor detection and discrimination and the physiological mechanisms that underlie this optimization. The proposed research has direct relevance to public health because they will establish parameters by which biological systems optimize odor signal processing; this in turn will aid design of artificial detector designs. Such detectors are used for diagnosis of human disease and detection of hazardous chemical traces in the environment as a disease prevention measure.,9417,SCS,Somatosensory and Chemosensory Systems Study Section,,2,291464,
7772254,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009434-02,,NIDCD:277380;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LEXINGTON,UNITED STATES,PHYSIOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"FROLENKOV, GREGORY I.;",8364177;,5R01DC009434,02/18/2009,01/31/2014,"4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; ATP Receptors; Acoustic; Acoustic Evoked Brain Stem Potentials; Acoustic Evoked Brainstem Potentials; Acoustic Nerve; Acoustics; Action Potentials; Affect; Agonist; Auditory Brain Stem Responses; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Function; Cell Process; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cochlea; Cochlear Organ; Cochlear structure; Corti Cell; Cortis Organ; Cranial Nerve Eight; Cranial Nerve VIII; Cyclic GMP; Cytoplasmic Membrane; Data; Deafness; Ear, Internal; Eighth Cranial Nerve; Evoked Potentials, Auditory, Brain Stem; Evoked Potentials, Auditory, Brainstem; Evoked Responses, Auditory, Brain Stem; Evoked Responses, Auditory, Brainstem; Face; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Genes; Goals; Gramicidin; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Hair Cells; Hair Cells, Outer; Hearing; Hearing Loss; Hearing Loss, Noise-Induced; Hypoacuses; Hypoacusis; Image; In Situ; In Vitro; Intervention; Intervention Strategies; Intracellular Second Messengers; Labyrinth; Lead; Lipid Peroxidation; Locomotor Activity; Mammals, Mice; Mediating; Methods; Methods and Techniques; Methods, Other; Mice; Molecular Motors; Motor; Motor Activity; Murine; Mus; Noise; Noise-Induced Hearing Loss; Operation; Operative Procedures; Operative Surgical Procedures; Organ of Corti; Organ of Corti structure; Otoacoustic Emissions, Spontaneous; Outer Hair Cells; Pathway interactions; Pb element; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Plasma Membrane; Predisposition; Preparation; Pres protein, rat; Process; Property; Property, LOINC Axis 2; Proteins; Public Health; Regulation; Research; Resistance; Scientist; Second Messenger Systems; Second Messengers; Sensory; Signal Pathway; Signal Transduction Pathway; Sound; Sound - physical agent; Spiral Organ; Spiral Organ of Corti; Spontaneous Otoacoustic Emissions; Stress; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; TRPA1 Channel; Techniques; Testing; VIIIth Cranial Nerve; Vestibulocochlear Nerve; Vibration; Vibration - physical agent; auditory nerve; base; cGMP; cell type; ear hair cell; extracellular; facial; flash photolysis; gene product; genetic variant; guanosine 3'5' monophosphate; hearing impairment; hearing perception; heavy metal Pb; heavy metal lead; imaging; in vivo; inner ear; interventional strategy; novel; otoacoustic emission; pathway; plasmalemma; prestin; prestin (motor protein), rat; prestin protein, rat; prevent; preventing; public health medicine (field); rat Pres protein; resistant; response; sound; sound perception; surgery; vibration",Regulation of outer hair cell electromotility and noise-induced hearing loss," NARRATIVE This research is relevant to public health because it investigates previously unknown mechanism that protects the inner ear from damage due to acoustic over-stimulation. The experimental results should help scientist to develop treatments for the noise-induced hearing loss, which is one of the most common cause of deafness and hearing impairment.",9434,AUD,Auditory System Study Section,,2,277380,
7772257,R01,DC,5,,02/01/2010,01/31/2011,PA-07-085,5R01DC009439-02,,NIDCD:576270;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ROCHESTER,UNITED STATES,PSYCHOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"BENNETTO, LOISA ;",1915405;,5R01DC009439,02/18/2009,01/31/2014,"0-11 years old; Adolescent; Adolescent Youth; Age; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Child; Child Youth; Children (0-21); Clinical; Cognitive; Detection; Development; Dysfunction; Eating; Eating Behavior; Ethnic Origin; Ethnicity; Ethnicity aspects; Family; Family member; Feeding behaviors; Food; Food Intake; Food Preferences; Functional disorder; Future; Gender; General Population; General Public; Genes; Genetic; Gustation; Handedness; Human; Human, Child; Human, General; Impairment; Individual; Ingestive Behavior; Intellectual disability; Intellectual functioning disability; Intellectual limitation; Kanner's Syndrome; Laterality; Link; Literature; Man (Taxonomy); Man, Modern; Matched Group; Measures; Memory; Modeling; Multivariate Analyses; Multivariate Analysis; Nature; Odors; Olfaction; Olfactions; Parents; Participant; Pattern; Performance; Phenotype; Physiopathology; Process; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Questionnaires; Race; Racial Group; Relative; Relative (related person); Reporting; Research; Role; Schizophrenia; Schizophrenic Disorders; Sensory; Siblings; Smell; Smell Perception; Social Behavior; Social Functioning; Social Identification; Social Identity; Socio-economic status; Socioeconomic Status; Specificity; Status, Socioeconomic; Stocks, Racial; Symptoms; Taste; Taste Perception; Testing; Work; autism spectrum disorder; children; dementia praecox; feeding; feeding-related behaviors; juvenile; juvenile human; nutrient intake activity; pathophysiology; proband; psycho-physiological; public health relevance; response; schizophrenic; social; social role; sociobehavior; sociobehavioral; trait; youngster","Taste, smell, and feeding behavior in autism: A quantitative traits study"," Project Narrative Sensory symptoms are a very significant clinical problem for individuals with autism. In this proposal, we will examine how individuals with autism process taste and smell information, and how difficulties in these abilities relate to other clinically important symptoms (e.g., restricted eating behavior). Inspired by a growing literature on the genetics of taste and smell, we will also study how these traits are shared within families who have a child with autism.",9439,BGES,Behavioral Genetics and Epidemiology Study Section,,2,576270,
7793443,R01,DC,5,,03/01/2010,02/28/2011,PA-07-070,5R01DC009455-02,,NIDCD:586669;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PORTLAND,UNITED STATES,OTOLARYNGOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"TRUNE, DENNIS ROYAL;",1890039;,5R01DC009455,03/25/2009,02/28/2014,"0-11 years old; 21+ years old; Acute; Adult; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; BALB/c; Bacteria; Body Tissues; Bone Morphogenetic Proteins; C3H/HeJ Mouse; Cells; Child; Child Youth; Children (0-21); Chronic; Clinical Treatment; Cochlea; Cochlear Diseases; Cochlear Organ; Cochlear structure; Connective Tissue; Cytokine Gene; DNA; DNA Synthesis Factor; Deoxyribonucleic Acid; Development; Disorder of middle ear; ECGF; Ear; Ear structure; Ear, Internal; Endothelial Cell Growth Factor; Expression Profiling; Expression Signature; FGF; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Gene Expression; Gene Expression Profile; Genes; Goals; HBGF; Hearing Loss, Sensorineural; Heating; Human, Adult; Human, Child; INFLM; Immune; Immune response; Inbred BALB C Mice; Inflammation; Inflammation Mediators; Inflammatory; Killings; Knockout Mice; Labyrinth; Lead; Mammals, Mice; Mediating; Mice; Mice, Inbred BALB C; Mice, Knock-out; Mice, Knockout; Molecular Fingerprinting; Molecular Profiling; Mouse, BALB C; Murein; Murine; Mus; Null Mouse; Otitis Media; Pathologic; Pathologic Processes; Pathological Processes; Pathology; Pathway interactions; Pb element; Peptides; Peptidoglycan; Phase; Process; Programs (PT); Programs [Publication Type]; Research; Role; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Hearing Loss; Staging; Steroid Compound; Steroids; TIL4; TLR protein; TLR2; TLR2 gene; TLR4 receptor; Therapeutic; Therapeutic Agents; Therapeutic Intervention; Time; Tissues; Toll-4 receptor; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4 Gene; VEGFs; Vascular Endothelial Growth Factors; Vegf; adult human (21+); children; cytokine; gene expression signature; heavy metal Pb; heavy metal lead; host response; immunoresponse; inner ear; insight; intervention development; intervention therapy; middle ear; middle ear disease; middle ear disorder; molecuar profile; molecular signature; mouse model; pathway; prevent; preventing; programs; public health relevance; social role; therapy development; toll-like receptor 4; transcriptome; treatment development; trial regimen; trial treatment; youngster",Inner Ear Impact of Chronic Middle Ear Inflammation," Public Health Relevance A study is proposed to evaluate the mechanisms by which chronic middle ear inflammation leads to cochlear pathology. Mouse models for acute and chronic middle ear disease will assess the role of different bacterial components on cytokine gene expression in the middle and inner ear and how this expression changes as inflammation transitions from an innate immune response to a cell-mediated adaptive immune response. Finally, various treatments will be targeted to these specific phases of inflammation to suppress the immune responses and protect the inner ear from permanent damage.",9455,AUD,Auditory System Study Section,,2,586669,
7777328,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009571-02,,NIDCD:303907;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,COLUMBIA,UNITED STATES,OTHER HEALTH PROFESSIONS,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"FRIDRIKSSON, JULIUS  (contact);RORDEN, CHRISTOPHER ;",7080428 (contact);7176898;,5R01DC009571,02/25/2009,01/31/2014,"21+ years old; Acquired brain injury; Acute; Adult; Affect; Alogia; Alogias; Anepia; Anepias; Anterior; Aphasia; Aphasia, Conduction; Apoplexy; Area; Area, Broca; Area, Wernicke; Associative aphasia; Auditory; Auditory Cortex; Auditory area; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Brain Injuries; Broca's area; Central Lobe; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Chronic Phase; Clinical; Communication; Comprehension; Conditioning Therapy; Country; Data; Discrimination, Speech; Disease; Disorder; Disputes; Dysphasia, Associative; Dysphasia, Conduction; Dysphasias, Associative; Dysphasias, Conduction; Forecast of outcome; Future; Goals; Hearing; Human; Human, Adult; Human, General; Impairment; Individual; Inferior; Injury; Insula; Insula of Reil; Interruption; Island of Reil; Language; Left; Lesion; Life Style Modification; Link; Location; Logagnosia; Logamnesia; Logamnesias; Logasthenia; Logasthenias; Longitudinal Studies; Man (Taxonomy); Man, Modern; Maps; Methods; Modeling; Motivation; Motor; Movement; Nature; Nervous; Oral; Output; Parietal Lobe; Parietal Lobe of the Brain; Participant; Patients; Perception; Physical Health Services / Rehabilitation; Play; Production; Prognosis; Recovery; Recruitment Activity; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Resistance; Role; Speech; Speech Discrimination; Speech Disorders; Speech Manifestations; Speech Perception; Staging; Stroke; Structure of Broca's area; Symptoms; Syndrome; Temporal Lobe; Testing; Transcranial magnetic stimulation; Vascular Accident, Brain; Visual; Visual Perception; Wernicke Area; Work; adult human (21+); auditory comprehension; base; behavior intervention; behavioral intervention; body movement; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; disability; disease/disorder; evidence base; frontal cortex; frontal lobe; hearing perception; hemisphere damage; improved; insight; language processing; long-term study; neural; neuropsychological; outcome forecast; parietal cortex; public health relevance; recruit; rehabilitative; relating to nervous system; resistant; social role; sound perception; speech processing; stroke; substantia alba; temporal cortex; temporal lobe/cortex; theories; white matter",A Unified Neuroanatomical Model of Speech Production and Perception: Implications," Apraxia of speech (AOS) and conduction aphasia are stroke related speech impairments which are extremely resistant to behavioral therapy, even when intensive treatment is applied. The purpose of this research is to study the underlying brain damage and impairment associated with AOS and conduction aphasia. As a result of this research, we will be able to study how stroke patients with AOS or conduction aphasia can be better rehabilitated to maximize their potential for recovery.",9571,LCOM,Language and Communication Study Section,,2,303907,
7766900,R01,DC,5,,02/01/2010,01/31/2011,PA-07-070,5R01DC009595-02,,NIDCD:289080;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOYS TOWN,UNITED STATES,,02,073136806,US,NE,68010,FATHER FLANAGAN'S BOYS' HOME,"HUGHES, MICHELLE L;",7844840;,5R01DC009595,02/06/2009,01/31/2014,"0-11 years old; Accounting; Acoustic Nerve; Affect; Auditory Prosthesis; Behavioral; Child; Child Youth; Children (0-21); Cochlear Implants; Cochlear Prosthesis; Cognitive Discrimination; Cranial Nerve Eight; Cranial Nerve VIII; Disadvantaged; Discrimination; Discrimination (Psychology); Eighth Cranial Nerve; Electrodes; Generations; Goals; Human, Child; Implant; Individual; Judgment; Lead; Location; Measures; Methods; Nervous; Pattern; Pb element; Perception; Performance; Peripheral; Physiologic; Physiological; Physiology; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; R01 Mechanism; R01 Program; RPG; Recovery; Refractory; Relative; Relative (related person); Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Sound; Sound - physical agent; Speech; Speech Perception; Stimulus; Testing; Time; Translating; Translatings; VIIIth Cranial Nerve; Vestibulocochlear Nerve; Work; auditory nerve; base; children; computerized data processing; data processing; heavy metal Pb; heavy metal lead; language translation; neural; preference; programs; psycho-physiological; relating to nervous system; response; signal processing; sound; speech processing; virtual; youngster",PHYSIOLOGY AS A POTENTIAL PREDICTOR OF PERCEPTION IN COCHLEAR IMPLANTS," PROJECT NARRATIVE  The goal of this research is to find objective ways to choose speech-processor programming parameters for cochlear implant recipients. The benefits are that recipients would be fit with an optimal program from the beginning of implant use. This is especially important for very young congenitally deafened children who cannot actively participate in formal speech-perception testing or sound-quality judgments, which are traditionally used to determine the best program for an individual.",9595,AUD,Auditory System Study Section,,2,289080,
7754851,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE003420-34,,NIDCR:458048;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BOSTON,UNITED STATES,,08,062190616,US,MA,02115,FORSYTH INSTITUTE,"TAUBMAN, MARTIN A;",1887742;,5R01DE003420,02/01/1976,01/31/2013,"21+ years old; Abscission; Adoptive Transfer; Adult; American; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Asses; B blood cells; B-Cells; B-Lymphocytes; Bacteroides gingivalis; Biliary or Urinary Stones; Biological; Body Tissues; Bone; Bone Resorption; Bone and Bones; Bones and Bone Tissue; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CDK4 Protein; Calculi; Cell Division Protein Kinase 4; Cell model; Cells; Cellular model; Chronic Periodontitis; Clinical; Common Rat Strains; Cyclin-Dependent Kinase 4; Cytokine Receptors; Donkey; Effector Cell; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Equus asinus; Excision; Experimental Models; Experimental Models, Other; Extirpation; Future; Galardin; Gingiva; Gingival; Goals; Human; Human, Adult; Human, General; Immune; Immune response; Immunity; Immunomodulation; In Vitro; Individual; Infection; Interleukin 1 Signal Transducer; Laboratories; Laboratory Study; Lead; Lesion; Ligands; Lymphocyte; Lymphocytic; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Methods; Microbial Biofilms; Miscellaneous Antibiotic; Modeling; Models, Experimental; Mononuclear; OCIF protein; ODF; OPG protein; OPGL; Operation; Operative Procedures; Operative Surgical Procedures; Osteoclastic Bone Loss; Osteoclasts; Outcome Measure; P. gingivalis; P.gingivalis; PBL; PBMC; PSK-J3 kinase; Parodontosis; Pathway interactions; Patients; Pb element; Periodontal Diseases; Periodontitis; Peripheral Blood Lymphocyte; Peripheral Blood Mononuclear Cell; Persons; Play; Porphyromonas gingivalis; Process; Production; Publishing; RANKL; Rat; Rattus; Receptor Protein; Receptors, Cytokine; Regimen; Removal; Research Resources; Resources; Role; Signal Pathway; Signaling Molecule; Stone; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; T-Cells; T-Lymphocyte; TNF receptor-associated factor 6; TNFRSF11B; TNFRSF11B gene product; TNFSF11; TNFSF11 gene; TRAF-6 Protein; TRAF6; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissues; Tooth; Tooth Loss; Tooth structure; Tumor Necrosis Factor Receptor Superfamily Member 11B; Tumor necrosis factor receptor 11b; adult human (21+); base; biofilm; bone; bone loss; cdk4 cyclin-dependent kinase; cyclin D-dependent kinase CDK4; experience; hRANKL2; heavy metal Pb; heavy metal lead; host response; immune modulation; immunologic reactivity control; immunoregulation; immunoresponse; in vitro Model; in vitro activity; in vivo; inhibiting antibody; inhibitor; inhibitor/antagonist; lymph cell; neutralizing antibody; new approaches; new therapeutics; next generation therapeutics; novel approaches; novel strategies; novel strategy; novel therapeutics; opg gene product; osteoclastogenesis; osteoclastogenesis inhibitory factor; osteoprotegerin; p34(cdk4); p34PSK-J3 kinase; p34PSK-J3-CDK4 kinase; pathogen; pathway; periodontal disorder; periodontium disease; periodontium disorder; peripheral blood; potency testing; prevent; preventing; receptor; resection; sOdf; social role; standard of care; surgery; synthetic peptide; teeth; thymus derived lymphocyte; translational study",Amelioration of Immune Cell-Mediated Periodontal Disease,,3420,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,34,458048,
7788096,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE009081-17,,NIDCR:344458;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BIRMINGHAM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"MICHALEK, SUZANNE M.;",1894566;,5R01DE009081,02/01/1996,01/31/2013,"APC; ATGN; Address; Adhesions; Adjuvant; Adoptive Transfer; Agonist; Antibody Formation; Antibody Production; Antibody Response; Antigen-Presenting Cells; Antigens; Antigens, Heterogenetic; Antigens, Heterophil; Antigens, Heterophile; Antigens, Xenogeneic; Antigens, Xenogenic; Attenuated; B blood cells; B-Cells; B-Lymphocytes; B7-1; BB1; Binding; Binding (Molecular Function); Buccal Cavity; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD28LG; CD28LG1; CD80; CD80 gene; Caries; Cavitas Oris; Cell Communication and Signaling; Cell Maturation; Cell Signaling; Cells; Chimera Protein; Chimeric Proteins; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Cholera Toxin B Subunit; Cholera Toxin Protomer B; Choleragen; Choleragenoid; Colony-forming units; Communicable Diseases; Complex; Cytidine Phosphates; Cytosine Nucleotides; Dendritic Cells; Dental Decay; Dental caries; Development; Effectiveness; Engineering; Engineerings; Event; Exposure to; Fusion Protein; GTase; Genes; Glucans; Glucose Polymer; Glucosyltransferase; Glucosyltransferases; Guanosine; H-D Antigens; Hanganutziu-Deicher Antigens; Head and Neck, Buccal Cavity; Head and Neck, Saliva; Heteroantigens; Heterologous Antigens; Heterophile Antigens; IgA; IgA, Exocrine; Immune response; Immune system; Immunity; Immunization; Immunoglobulin A; Immunoglobulin A, Secretory; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; L-Lysine; LAB7; LPS; LRR; Leucine-Rich Repeat; Life; Link; Lipopolysaccharides; Lysine; Mediating; Memory; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Mouth; Mucosal Immune Responses; Nature; Null Mouse; Oral cavity; Outcome; Parodontosis; Pattern; Pattern recognition receptor; Paul-Bunnell Antigens; Periodontal Diseases; Peyer's Patches; Phosphate Buffer; Play; Polyglucoses; Receptor Protein; Receptor Signaling; Recombinants; Regimen; Research; Right-Handed Beta-Alpha Superhelix; Role; S. mutans; S.mutans; SIgA; Saline; Saline Solution; Saliva; Salmonella; Salmonella Vaccines; Salmonellosis Vaccines; Secretory IgA; Secretory Immunoglobulin A; Sensitization, Immunologic; Sensitization, Immunological; Signal Transduction; Signal Transduction Systems; Signaling; Streptococcus mutans; Structure of aggregated lymphoid follicle of small intestine; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TLR protein; TP-1; Testing; Thymus-Dependent Lymphocytes; Toll-like receptors; Vaccines; Veiled Cells; Virulence; Xenoantigens; accessory cell; antibody biosynthesis; biological signal transduction; body system, allergic/immunologic; design; designing; experiment; experimental research; experimental study; fetal bovine serum; fluorescence activated cell sorter; fluorescence activated cell sorter device; gene cloning; host response; immunogen; immunoglobulin biosynthesis; immunoresponse; improved; in vitro Assay; in vivo; infectious organism; microbial; microbial antigen; microorganism antigen; mucosal vaccine; oral vaccine; organ system, allergic/immunologic; pathogen; periodontal disorder; periodontium disease; periodontium disorder; plasmid vaccine; public health relevance; receptor; research study; response; social role; thymus derived lymphocyte; tooth decay; vaccine candidate; vector; vector vaccine",Genetically Engineered Oral Vaccines and Caries Immunity," PROJECT NARRATIVE Recombinant attenuated Salmonella vaccines are being developed and tested for their effectiveness in inducing protective mucosal and systemic immune responses to a variety of infectious agents, including the etiologic agents of dental caries and periodontal disease. Live vector vaccines are more effective in inducing mucosal immune responses against microbial pathogens and more economical to produce than vaccines consisting of purified microbial components. Therefore, it is critical to determine the mechanisms involved in host recognition of microbial components of a Salmonella vector vaccine that regulate the nature of the immune response induced to the expressing cloned virulence antigen of a heterologous pathogen, such as mutans streptococci, in order to develop recombinant avirulent Salmonella vaccines that are highly effective in potentiating protective immune responses against mucosal pathogens, including those associated with the oral cavity.",9081,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,17,344458,
7763916,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE011089-12,,NIDCR:396970;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,PHILADELPHIA,UNITED STATES,ANATOMY/CELL BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GIBSON, CAROLYN W.;",2413815;,5R01DE011089,06/01/1995,01/31/2013,"129 Mouse; A/J Mouse; Acids; Affect; Amelogenesis Imperfecta; Amino Acids; Animal Model; Animal Models and Related Studies; Anxiety; Appearance; Backcrossings; Biomechanics; Blotting, Western; C-terminal; Characteristics; Classification; Clinical; Clinical Treatment; Congenic Mice; Congenic Strain; DNA; DNA Alteration; DNA mutation; Defect; Dental; Dental Enamel; Deoxyribonucleic Acid; Development; Dimensions; Enamel; Environment; Extracellular Matrix Proteins; Gene Alteration; Gene Mutation; Gene-Modified; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genomics; Growth; Hereditary; Heterogeneity; Human; Human Development; Human, General; Individual; Inherited; Intervention; Intervention Strategies; Knockout Mice; Knowledge; LRAP; LRAPeptide; Lead; Light; Link; MMP-20; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mice; Mice, Congenic; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microscopy, Electron, Scanning Transmission; Minerals; Modeling; Mouse Strains; Murine; Mus; Mutate; Mutation; Null Mouse; Odontogenesis; Oral; Oral health; Pain; Painful; Patients; Pb element; Phenotype; Photoradiation; Play; Polymorphic Microsatellite Marker; Polymorphic marker; Process; Proteins; Proteolytic Clipping; Proteolytic Processing; Rodent; Rodentia; Rodentias; Role; Scanning Transmission Electron Microscopy Procedures; Sequence Alteration; Severity of illness; Speed; Speed (motion); Structure; Systematics; Testing; Therapeutic; Thick; Thickness; Tissue Growth; Tooth; Tooth structure; Transgenes; Transgenic Mice; Transgenic Model; Transgenic Organisms; Western Blotting; Western Blottings; Western Immunoblotting; Work; amelogenin; aminoacid; base; congenic; dental development; dental health; design; designing; disease severity; enamelin; gene product; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; insight; interdisciplinary approach; intervention design; interventional strategy; kindred; leucine-rich amelogenin peptide; leucine-rich amelogenin polypeptide; matrix metalloproteinase 20; microleakage; model organism; mouse model; null mutation; ontogeny; prevent; preventing; protein blotting; restoration; restorative treatment; social; social role; teeth; therapy design; tooth enamel; transgenic; treatment design; treatment planning; trial regimen; trial treatment; tuftelin",Enamel Mineral Formation during Murine Odontogenesis,,11089,ZRG1,Special Emphasis Panel,,12,396970,
7763790,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE011723-13,,NIDCR:335126;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,ANN ARBOR,UNITED STATES,DENTISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"FRANCESCHI, RENNY THEODORE;",1869646;,5R01DE011723,09/01/1995,01/31/2012,"21+ years old; Adult; Age-Months; Aging; Antimorphic mutation; Autoregulation; Basic Fibroblast Growth Factor Gene; Biochemical Genetics; Biological; Body Tissues; Bone; Bone Formation; Bone and Bones; Bone remodeling; Bones and Bone Tissue; Calvaria; Cell Adhesion; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Adhesion; Cephalic; Chemotherapy-Hormones/Steroids; Chromatin; Complex; Consensus; Cranial; DNA; Deoxyribonucleic Acid; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; EC 2.7.2-; ECM; ERK MAP Kinases; Endocrine Gland Secretion; Environment; Exercise; Exercise, Physical; Extracellular Matrix; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; FGF2; FGF2 gene; FGFB; Fibroblast Growth Factor 2 Gene; GFAC; Gene Expression; Gene Family; Gene Transcription; Genes, Regulator; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic, Biochemical; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Homeostasis; Hormonal; Hormones; Human, Adult; IGF1; IGF1 gene; IGFI; In Vitro; Intracellular Communication and Signaling; Kinases; Knock-in; Knock-in Mouse; L-Serine; Laboratories; Life; Link; Load-Bearing; Loadbearing; MAP kinase; MAP2K1; MAP2K1 gene; MAPK; MAPKK1; MEK1; MKK1; Mammals, Mice; Maps; Marrow; Mechanical Stimulation; Mechanics; Mediating; Mesenchymal Differentiation; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Modeling; Murine; Mus; Mutation; Nuclear; Nucleus; Oophorectomy; Osteoblasts; Osteocytes; Osteogenesis; Osteoporosis; Ovariectomy; PRKMK1; Pathway interactions; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Proteins; RNA Expression; Regulation; Regulator Genes; Role; Senescence; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Development; Skeleton; Stimulus; Stromal Cells; Study models; Testing; Therapeutic; Therapeutic Hormone; Threonine/Tyrosine Protein Kinase; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transcriptional Regulatory Elements; Transgenes; Transgenic Mice; Transphosphorylases; Up-Regulation; Weight-Bearing; Weight-Bearing state; Weightbearing; adult animal; adult human (21+); age dependent; age related; base; biological signal transduction; bone; bone loss; bone remodelling; calvarial; expression vector; extracellular; extracellular signal related kinase; female gonadectomy; fluid flow; gene product; genome mutation; in vivo; mature animal; mineralization; mutant; novel; novel therapeutic intervention; osteoblast differentiation; pathway; prevent; preventing; regulatory gene; response; senescent; shear stress; social role; trans acting element; transcription factor",MAP KINASE REGULATION OF OSTEOBLAST FUNCTION,,11723,SBDD,Skeletal Biology Development and Disease Study Section,,13,335126,
7755846,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE012554-13,,NIDCR:557020;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,SEATTLE,UNITED STATES,BIOMEDICAL ENGINEERING,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"STAYTON, PATRICK S.;",2418359;,5R01DE012554,09/30/1997,01/31/2013,"3-D structure; 3-dimensional structure; 3D structure; Adsorption; Alanine; Alanine, L-Isomer; Algorithms; Arterial Fatty Streak; Artificial Heart; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atomic Force Microscope; Atomic Force Microscopy; Bacterial Adhesion; Biliary or Urinary Stones; Binding; Binding (Molecular Function); Binding Sites; Biocompatible Materials; Biomaterials; Biomimetics; Blood Vessels; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Calculi; Calorimetry; Cardiac Valves; Caries; Combining Site; Dental; Dental Calculus; Dental Decay; Dental caries; Development; Diagnostic; Electrostatics; Engineering; Engineerings; Entropy; Force Microscopy; Free Energy; Frequencies (time pattern); Frequency; Generalized Growth; Generations; Genetics-Mutagenesis; Gingivitis; Goals; Growth; Heart Valves; Heart, Artificial; Hydrogen Oxide; Hydroxyapatites; Kidney; Kidney Calculi; Kidney Stones; Kinetic; Kinetics; L-Alanine; Lateral; Macromolecular Structure; Maintenance; Maintenances; Maps; Measurement; Measures; Medical; Methods and Techniques; Methods, Other; Microscopy, Atomic Force; Mimetics, Biological; Minerals; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecular Structure; Mutagenesis; Mutagenesis, Site-Directed; Nature; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Outcome; Pathologic Processes; Pathological Processes; Peptides; Phase; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Dynamics; Proteins; Reactive Site; Renal Calculi; Renal Stone; Research; Resolution; Role; Route; Salivary Gland Proteins; Salivary Proteins; Scanning; Scanning Force Microscopy; Side; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Solid; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Spinal Column; Spine; Stone; Streaks, Arterial Fatty; Structure; Structure-Activity Relationship; Sum; Surface; Targeted DNA Modification; Targeted Modification; Tartar; Techniques; Testing; Thermodynamic; Thermodynamics; Tissue Engineering; Tissue Growth; Tissues; Tooth; Tooth Demineralization; Tooth Hypomineralization; Tooth Hypomineralizations; Tooth structure; Urinary System, Kidney; Urology; Vertebral column; Water; abstracting; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; backbone; biocompatibility; biomaterial compatibility; biomineralization; bone; calcification; calcification inhibitor; cardiac prosthesis; chemical structure function; conformation; conformational state; design; designing; engineered tissue; enthalpy; fimbrillin; frontier; gene product; heart prosthesis; improved; insight; interest; mechanical heart; molecular recognition; mutant; nephrolith; ontogeny; programs; protein folding; protein function; protein protein interaction; protein structure; protein structure function; renal; scaffold; scaffolding; social role; solid state nuclear magnetic resonance; statherin; structure function relationship; surface coating; teeth; three dimensional structure; tooth decay; vascular; vulnerable plaque",Protein-Crystal Molecular Recognition in Biomineralization,,12554,BMBI,Biomaterials and Biointerfaces Study Section,,13,557020,
7795936,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE013123-09,,NIDCR:259281;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,HEIDELBERG,GERMANY,,,325989556,GM,,69120,GERMAN CANCER RESEARCH CENTER,"PLASS, CHRISTOPH ;",1879382;,5R01DE013123,04/01/2000,01/31/2012,"6q23-q24; Address; Alternate Splicing; Alternative Splicing; Anti-Oncogenes; Antioncogenes; Assay; Athymic Nude Mouse; B lymphoma; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; BHLH Protein; Basic HLH Protein; Basic Helix-Loop-Helix Protein; Basic Helix-Loop-Helix Transcription Factors; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Buccal Cavity; Cancer Causing Agents; Cancer Induction; Cancer cell line; Cancer of Breast; Cancer of Lung; Cancers; Carcinogens; Cavitas Oris; Cell Line; Cell Lines, Strains; CellLine; Cells; Chromosomal Loss; Chromosomes; Cobra; Computer Programs; Computer software; Correlative Study; Crossmatching, Tissue; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Drug Formulations; Drugs, Nonproprietary; Emerogenes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Formulation; Formulations, Drug; Frequencies (time pattern); Frequency; Gel; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Targeting; General Transcription Factor Gene; Generic Drugs; Genes; Genes, Cancer Suppressor; Genes, Metastasis Suppressor; Genes, Onco-Suppressor; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genomics; Goals; Grant; HNSCC; Head and Neck; Head and Neck Cancer; Head and Neck Carcinoma; Head and Neck Squamous Cell Carcinoma; Head and Neck, Buccal Cavity; Head and neck structure; Histocompatibility Testing; Human; Human, General; Immunologic, Luciferase; In Vitro; Knockout Mice; Libraries; Luc Gene; Luciferase Gene; Luciferases; Lung; Malignant Head and Neck Neoplasm; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Head and Neck; Malignant Tumor of the Lung; Malignant neoplasm of breast; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Measures; Metastasis; Metastasis Suppressor Genes; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Methylation; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Nude; Molecular Biology, Mutagenesis; Molecular Interaction; Mouth; Mutagenesis; Mutant Strains Mice; Mutation; Mutation Detection; Neoplasm Metastasis; Normal Tissue; Normal tissue morphology; Nude Mice; Null Mouse; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogens; Oral cavity; Ovarian; Pattern; Profilings, Gene Expression; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Proto-Oncogene, Transcription Factor; Pulmonary Cancer; Pulmonary malignant Neoplasm; RNA Splicing, Alternative; Reporter; Research Resources; Resources; Respiratory System, Lung; Role; SCCHN; Scanning; Secondary Neoplasm; Secondary Tumor; Software; Stomach; System; System, LOINC Axis 4; Targetings, Gene; Tissue Crossmatchings; Tissue Typing; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; Transcription factor genes; Tumor Cell Migration; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tumorigenicity; Two Hybrid; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; base; bisulfite; cancer metastasis; carcinogenesis; clinical data repository; clinical data warehouse; computer program/software; cultured cell line; data repository; experiment; experimental research; experimental study; gastric; generic; genome mutation; head & neck cancer; head & neck tumor; histocompatibility typing; hydrogen sulfite; hydrosulfite; in vivo; lung cancer; lung carcinogenesis; malignancy; malignant breast neoplasm; melanoma; mouse model; mouse mutant; neoplasm/cancer; novel; oncosuppressor gene; overexpression; pulmonary; relational database; research study; shRNA; short hairpin RNA; small hairpin RNA; social role; sodium bisulfite; tumor; tumor suppressor; tumorigenesis; tumorigenic; yeast two hybrid system",Genomic Scanning for Generic and Epigenetic Alterations in head and neck cancer,,13123,TPM,Tumor Progression and Metastasis Study Section,,9,259281,
7747972,R01,DE,5,,01/01/2010,12/31/2010,,5R01DE013814-09,,NIDCR:603469;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,CHAPEL HILL,UNITED STATES,DENTISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TROTMAN, CARROLL ANN;",6394707;,5R01DE013814,07/01/2000,12/31/2010,"0-11 years old; 12-20 years old; Active Follow-up; Address; Adolescence; Appearance; Caring; Child; Child Youth; Children (0-21); Cicatrix; Cleaved cell; Cleft Lip; Clinical; Clinical Data; Clinical Trials; Clinical Trials, Unspecified; Control Groups; Country; Data; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Decision Making; Dental Care; Dental Procedure; Development; Effectiveness; Effects, Longterm; Enrollment; Esthesia; Evaluation; Face; Future; Goals; Grant; Harelip; Human, Child; Impairment; Individual; Investigation; Lip; Lip structure; Long-Term Effects; Maintenance; Maintenances; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Morphology; Movement; Nasal; North Carolina; Nose; Nose, Nasal Passages; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Parents; Patient Care; Patient Care Delivery; Patients; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Randomized Clinical Trials; Recommendation; Recruitment Activity; Research; Respiratory System, Nose, Nasal Passages; Rest; Risk; Scars; School Dentistries; School Dentistry; Sensation; Sensory; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Time; Trials, Randomized Clinical; Universities; adolescence (12-20); base; body movement; children; cleaved; cleft lip and palate; clinical data repository; clinical data warehouse; clinical investigation; cohort; craniofacial; craniofacies; data repository; enroll; facial; follow-up; functional outcomes; hare lip; improved; lip function; meetings; programs; recruit; relational database; repair; repaired; soft tissue; surgery; teenage; treatment planning; youngster",Functional Outcomes of Cleft Lip Surgery,,13814,ZDE1,Special Emphasis Panel,,9,603469,
7761190,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE013902-09,,NIDCR:372773;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,DALLAS,UNITED STATES,PHYSIOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"MUALLEM, SHMUEL ;",1881279;,5R01DE013902,03/01/2001,01/31/2012,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; Adrenergic Receptor; Adrenoceptors; Agents, Muscarinic; Agonist; Antibodies; Asialia; Asialias; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; Biotinylation; Blotting, Western; Brain; Ca Release Channel-Ryanodine Receptor; Calcium-Ryanodine Receptor Complex; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Complex; Cytoplasmic Membrane; Data; Development; Dysfunction; EGFR; ERBB Protein; ERBB1; Electrolytes; Encephalon; Encephalons; Endocrine Gland Secretion; Endoplasmic Reticulum; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Ergastoplasm; Fluids and Secretions; Fluorescence; Functional disorder; G Protein-Complex Receptor; G Protein-Coupled Receptor Genes; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G0S8; GOK Gene; GPCR; GPCR Signaling; GPR; GeneHomolog; Glycerin; Glycerol; Goals; HER1; Head and Neck, Salivary Glands; Homolog; Homologous Gene; Homologue; Hormones; Hyposalivation; Hyposalivations; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Lead; Liquid substance; Mammals, Mice; Mediating; Membrane Potentials; Methods and Techniques; Methods, Other; Mice; Model System; Modeling; Models, Biologic; Molecular Interaction; Mouth Diseases; Mouth Dryness; Murine; Mus; Muscarinics; N-terminal; NH2-terminal; Nerve Transmitter Substances; Nervous System, Brain; Neurabin; Neurotransmitters; Oral Cavity Disease; Oral Cavity Disorder; Oral Disease; Oral Disorder; Pb element; Physiopathology; Plasma Membrane; Play; Programs (PT); Programs [Publication Type]; Proteins; Pump; RGS Family Protein; RGS Protein (G-Protein Signaling); RGS Proteins; RGS2; RGS2 gene; Radiation; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Epinephrine; Receptors, Ryanodine; Regulation; Regulators of G-Protein Signaling Proteins; Reporting; Research Personnel; Researchers; Resting Potentials; Retrieval; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; STIM1; STIM1 gene; Salivary Glands; Scaffolding Protein; Scheme; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Sjogren's Syndrome; Sjogrens; Stromal Interaction Molecule 1 Gene; Subcellular Process; Techniques; Testing; Therapeutic Hormone; Transforming Growth Factor alpha Receptor; Transmembrane Potentials; Western Blotting; Western Blottings; Western Immunoblotting; Work; Xerostomia; Xerostomias; adenoreceptor; aptyalism; basolateral membrane; biological signal transduction; c-erbB-1; c-erbB-1 Protein; dry mouth; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; fluid; gene product; heavy metal Pb; heavy metal lead; in vivo; liquid; luminal membrane; mouth disorder; neurabin II; novel; p180 neurabin; parotid cell; pathophysiology; plasmalemma; programs; protein blotting; proto-oncogene protein c-erbB-1; ray (radiation); receptor; scaffold; scaffolding; social role; spinophilin; trafficking",Signaling Mechanisms in Salivary Gland Cells,,13902,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,9,372773,
7761255,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE014080-08,,NIDCR:296947;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"OFFNER, GWYNNETH D;",1959802;,5R01DE014080,04/01/2001,01/31/2011,"Activities of Daily Living; Activities of everyday life; Architecture; Assay; Bacterial Model; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blotting, Far-Western; Blotting, West-Western; Buccal Cavity; Cavitas Oris; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell surface; CellLine; Cells; Chemical Injury; Chemicals; Co-Immunoprecipitations; Complex; Cues; Deglutition; Diffusion; Dissociation; Engineering / Architecture; Environment; Enzymes; Epithelial; Epithelial Cells; Epithelium; Far-Western Blotting; Far-Western Blottings; Gel; Gene Expression; Genes; Genitourinary; Genitourinary system; Head and Neck, Buccal Cavity; Head and Neck, Saliva; Head and Neck, Salivary Glands; Host Defense; Immune response; Inflammation Mediators; Injury; Intracellular Communication and Signaling; Investigators; MG1; MUC1; MUC2; MUC5B; MUC5B gene; Maps; Mass Spectrum; Mass Spectrum Analysis; Mechanics; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Microbe; Molecular; Molecular Interaction; Molecular Weight; Mouth; Mucin 2; Mucin-1 Staining Method; Mucin-2 Staining Method; Mucins; Mucus Glycoprotein; Oral; Oral cavity; Parodontosis; Periodontal Diseases; Photometry/Spectrum Analysis, Mass; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Receptor Protein; Research Personnel; Researchers; Role; Saliva; Salivary; Salivary Gland Proteins; Salivary Glands; Salivary Proteins; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Speech; Structure; Surface; Swallowing; System; System, LOINC Axis 4; Time; Translating; Translatings; Two Hybrid; Urogenital; Urogenital System; West-Western Blottings; Yeast One Hybrid System; Yeast One/Two-Hybrid System; base; biological signal transduction; cultured cell line; daily living functionality; extracellular; functional ability; functional capacity; gastrointestinal; gene product; host response; immunoresponse; infection mouth; language translation; membrane structure; microbial; new therapeutic target; oral bacteria; oral cavity epithelium; oral epithelia; oral epithelium; oral flora; oral infection; oral infectious; periodontal disorder; periodontium disease; periodontium disorder; prevent; preventing; programs; receptor; residence; respiratory; response; salivary mucins; scaffold; scaffolding; social role; urogenital system (urinary part); yeast two hybrid system",Membrane Bound Mucins in Salivary Glands and Saliva,,14080,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,8,296947,
7755848,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE015207-07,,NIDCR:369716;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,ROCHESTER,UNITED STATES,GENETICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"JIANG, RULANG ;",7700818;,5R01DE015207,04/01/2003,01/31/2013,"12-20 years old; Adolescence; Affect; Animal Model; Animal Models and Related Studies; Biochemical Genetics; Biological Models; Birth Defects; Body Tissues; Candidate Disease Gene; Candidate Gene; Causality; Cell Communication and Signaling; Cell Signaling; Chromosome Mapping; Chromosomes; Cleaved cell; Cleft Lip; Cleft Palate; Cleft lip with or without cleft palate; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA Alteration; DNA mutation; Dancer mutation; Data; Defect; Dental; Development; Diagnosis; Ear, Internal; Ectopic Expression; Embryo; Embryonic; Environmental Factor; Environmental Risk Factor; Etiology; Exons; Expression Profiling; Expression Signature; Face; Gene Alteration; Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Mutation; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetic, Biochemical; Genetics, Gene Mapping; Goals; Harelip; Heterozygote; Homeo Domain; Homolog; Homologous Gene; Homologue; Homozygote; Human; Human, General; Individual; Intracellular Communication and Signaling; Isoforms; Labyrinth; Lead; Lesion; Linkage Mapping; Live Birth; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical; Mesenchymas; Mesenchyme; Messenger RNA; Mice; Mice, Mutant Strains; Mice, Transgenic; Model System; Modeling; Models, Biologic; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Molecular Profiling; Murine; Mus; Mutant Strains Mice; Mutation; Names; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Pathogenesis; Pathway interactions; Pb element; Phenotype; Prevention; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Proteins; Proto-Oncogene, Signaling Factor; RNA, Messenger; Race; Racial Group; Research; SEQ-AN; Sequence Alteration; Sequence Analyses; Sequence Analysis; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway Gene; Speech; Stocks, Racial; Surgical; Surgical Interventions; Surgical Procedure; Tissues; Transgenic Mice; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; adolescence (12-20); base; biological signal transduction; cl/p; cleaved; cleft lip and palate; craniofacial; craniofacies; disease causation; disease etiology; disease/disorder etiology; disorder etiology; environmental risk; facial; gene cloning; gene function; gene product; genetic mapping; genome mutation; hare lip; heavy metal Pb; heavy metal lead; homeodomain; infancy; infantile; inner ear; insight; mRNA; method development; model organism; molecuar profile; molecular signature; mouse mutant; mutant; mutant mouse model; orofacial; pathway; positional cloning; psychologic; psychological; reverse genetics; surgery; teenage; transcription factor",GENETIC BASIS OF CLEFT LIP AND PALATE,,15207,SBDD,Skeletal Biology Development and Disease Study Section,,7,369716,
7744658,R01,DE,5,,01/01/2010,12/31/2010,,5R01DE016686-04,,NIDCR:251742;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,KANSAS CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"BISWAS, INDRANIL ;",7845326;,5R01DE016686,02/01/2007,12/31/2011,"Adherence; Adherence (attribute); Affect; Animal Experiments; Assay; Attenuated; Bacterial Infections; Band Shift Mobility Assay; Bandshift Mobility Assay; Beta-glucuronidase; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Carbohydrates; Caries; Cell Communication and Signaling; Cell Signaling; Cellular Stress Response; Characteristics; Cloning; Combining Site; Common Rat Strains; Country; Cues; DNA; DNA Binding; DNA Binding Interaction; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA-Binding Proteins; Dental Decay; Dental Plaque; Dental caries; Deoxyribonucleic Acid; EC 2.7; EMSA; Electrophoretic Mobility Shift Assay; Elements; Environmental Factor; Environmental Risk Factor; Epidemiology; Experiments, Animal; Family; Foot; GTase; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genes, Reporter; Genetic; Genetic, Biochemical; Genetics-Mutagenesis; Genome; Genomics; Glucans; Glucose Polymer; Glucosyltransferase; Glucosyltransferases; Glucuronidase; Goals; GtfD; HTH DNA Binding Domain; HTH Motifs; Helix-Turn-Helix Motifs; Human; Human, General; Hydrogen Oxide; In Vitro; Intracellular Communication and Signaling; Investigators; Kinases; Mammals, Rats; Man (Taxonomy); Man, Modern; Methods; Microbial Biofilms; Mobility Shift Assay; Modeling; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Mutagenesis; Operon; Organism; Orphan; Pathogenesis; Pathogenicity Factors; Pathway interactions; Peptide Biosynthesis, Ribosomal; Pes; Phase; Phosphorylation; Phosphotransferases; Play; Polyglucoses; Printing; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Phosphorylation; Protein Synthesis, Ribosomal; Proteins; Proteomics; Protocol; Protocols documentation; Rat; Rattus; Reactive Site; Regulation; Regulon; Reporter; Reporter Genes; Reporting; Research Personnel; Researchers; Role; S. agalactiae; S. mutans; S. pyogenes; S.agalactiae; S.mutans; S.pyogenes; Saccharose; Sequence Homology; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Streptococcus; Streptococcus Group A; Streptococcus Group B; Streptococcus agalactiae; Streptococcus mutans; Streptococcus pyogenes; Sucrose; Surface; System; System, LOINC Axis 4; Testing; Transphosphorylases; Two Hybrid; Variant; Variation; Virulence; Virulence Factors; Water; Yeast One Hybrid System; Yeast One/Two-Hybrid System; alpha 1,6-glucan synthase; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; bacterial disease; base; beta-D-Glucuronoside glucuronosohydrolase; beta-glucan-binding protein; biofilm; biological signal transduction; design; designing; environmental risk; experiment; experimental research; experimental study; foot; gel shift assay; gene product; glucan-binding protein; glucosyltransferase D; helix loop helix; helix turn helix; homology (molecular); improved; in vivo; living system; mutant; novel; pathogen; pathway; programs; protein synthesis; research study; response; sensor; social role; therapeutic development; tooth decay; tooth surface; yeast two hybrid system",Mechanisms of Virulence Gene Regulation in Streptococcus mutans,,16686,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,4,251742,
7759574,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE016715-05,,NIDCR:265256;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,GAINESVILLE,UNITED STATES,DENTISTRY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"LAMONT, RICHARD J;",7359433;,5R01DE016715,02/21/2006,01/31/2011,"A. actinomycetemcomitans; Actinobacillus actinomycetemcomitans; Assay; Autoregulation; Bacteria; Bacterial Adhesion; Bacterial Physiology; Bacterium actinomycetem comitans; Bacterium comitans; Bacteroides gingivalis; Bioassay; Biologic Assays; Biological Assay; Buccal Cavity; Cavitas Oris; Cell Communication and Signaling; Cell Components; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Structure; CellLine; Cells; Cellular Structures; Co-culture; Cocultivation; Coculture; Coculture Techniques; Complex; Data; Disease; Disorder; Effector Cell; Epithelial Cells; Epithelium; Equilibrium; Face; Genetic Alteration; Genetic Change; Genetic defect; Gingiva; Gingival; Goals; Head and Neck, Buccal Cavity; Health; Homeostasis; Human; Human, General; Immune; Immune response; Individual; Infection; Intracellular Communication and Signaling; Invaded; Investigators; Lead; Life Style; Lifestyle; Man (Taxonomy); Man, Modern; Measures; Membrane; Microbe; Mouth; Mutation; Oral; Oral cavity; Organism; P. gingivalis; P.gingivalis; Parodontosis; Pathogenesis; Pathway interactions; Pb element; Periodontal Diseases; Physiological Homeostasis; Porphyromonas gingivalis; Printing; Programs (PT); Programs [Publication Type]; Proteins; R01 Mechanism; R01 Program; RPG; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; S. gordonii; S.gordonii; Signal Transduction; Signal Transduction Systems; Signaling; Streptococcus gordonii; System; System, LOINC Axis 4; Testing; Time; Toxic effect; Toxicities; Virulence; balance; balance function; base; biological signal transduction; clinical relevance; clinically relevant; cultured cell line; disease/disorder; facial; gene product; genome mutation; heavy metal Pb; heavy metal lead; host response; immunoresponse; insight; living system; membrane structure; microbial; oral cavity epithelium; oral commensal; oral epithelia; oral epithelium; pathogen; pathway; periodontal disorder; periodontium disease; periodontium disorder; periopathogen; plaque microorganism; programs; response",Epithelium-Microbe Interactions Dissected with Arrays,,16715,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,5,265256,
7751894,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE017078-05,,NIDCR:396314;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,SEATTLE,UNITED STATES,,07,070967955,US,WA,98109,SEATTLE BIOMEDICAL RESEARCH INSTITUTE,"WHITE, THEODORE C.;",1876443;,5R01DE017078,02/01/2006,01/31/2011,"1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Active Biological Transport; Active Transport; Affect; Anabolism; Antifungal Agents; Antifungal Drug; Antifungal Therapy; Area; Assay; Azole resistance; Azole resistant; Azoles; Bioassay; Biochemical; Biologic Assays; Biologic Transport, Active; Biological Assay; Biological Transport, Active; C. albicans; C.albicans; Candida albicans; Cell Communication; Cell Cycle; Cell Division Cycle; Cell Interaction; Cell membrane; Cell surface; Cell-to-Cell Interaction; Cells; Clinical; Complex; Cues; Cytoplasmic Membrane; Data; Diagnosis; Drug Interactions; Drugs; Effectiveness; Environment; Environmental Factor; Environmental Risk Factor; Enzymes; Ergosta-5,7,22-trien-3-ol, (3beta,22E)-; Ergosterol; Fluconazole; Fungal Components; Fungicides, Therapeutic; Fungus Diseases; Future; Gene Expression; Genes; Goals; Immune; Immunologic Deficiency Syndrome, Acquired; In Vitro; In-111; In111 isotope; Indium-111; Intermediary Metabolism; Investigators; Lead; METBL; Mediating; Medication; Messenger RNA; Metabolic Processes; Metabolism; Moniliasis, Oral; Mycoses; N element; N2 element; Nitrogen; O element; O2 element; Oral; Oral candidiasis; Oxygen; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasma Membrane; Point Mutation; Poisons; Population; Predisposition; Prevention; Probability; Process; RNA, Messenger; Regulation; Research; Research Personnel; Researchers; Resistance; Resistance development; Resistance to infection; Resistant development; Source; Sterol Biosynthesis; Sterol Biosynthesis Pathway; Sterols; Susceptibility; Testing; Thrush; Toxic Chemical; Toxic Substance; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Uphill Transport; Yeasts; alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; anti-fungal; antifungals; biosynthesis; candida of mouth; clinical significance; clinically significant; developing resistance; diflucan; drug/agent; efflux pump; environmental risk; fungal infection; fungus infection; heavy metal Pb; heavy metal lead; improved; infection resistance; insight; mRNA; mycotic stomatitis; oral candida; overexpression; patient population; plasmalemma; poison; resistance mechanism; resistance to azole; resistant; resistant mechanism; resistant strain; resistant to azole; response; thrush (disorder); toxic compound; transcription factor; treatment of fungal infectious disease; uptake","AIDS Related Oral Candidiasis: Drugs, Sterols, and Fungal Cells",,17078,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,5,396314,
7755037,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE017138-05,,NIDCR:346100;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,LOUISVILLE,UNITED STATES,DENTISTRY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"HAJISHENGALLIS, GEORGIOS ;",6716983;,5R01DE017138,02/01/2006,01/31/2011,"APC; ATGN; Address; Adhesins, Bacterial; Adjuvant; Adjuvanticity; Agonist; Antibodies; Antigen-Presenting Cells; Antigens; Arts; Assay; Bacterial Adhesins; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood monocyte; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell model; Cell physiology; CellLine; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular model; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Co-Immunoprecipitations; Complex; Data; Dendritic Cells; Drug Formulations; E coli; Engineering; Engineerings; Enterotoxins; Escherichia coli; Exhibits; FRET; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; Formulation; Formulations, Drug; GD(1a) ganglioside; GD1a ganglioside; Gangliosides; Genitourinary; Genitourinary system; Human; Human, General; Imaging Procedures; Imaging Techniques; Immune response; Immunity; Immunity, Mucosal; Immunization; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infection; Intracellular Communication and Signaling; Invaded; Investigation; Investigators; Ligands; Lipid Rafts, Cell Membrane; Lymphoid Cell; Macromolecular Structure; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Membrane Microdomains; Methods and Techniques; Methods, Other; Mice; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular; Molecular Interaction; Molecular Structure; Monitor; Monocytes / Macrophages / APC; Mucosa; Mucosal Immune Responses; Mucosal Immunity; Mucosal Tissue; Mucous Membrane; Murine; Mus; Oral; Play; Point Mutation; Production; Programs (PT); Programs [Publication Type]; Proteins; Reagent; Receptor Protein; Research Personnel; Researchers; Role; Route; S. mutans; S.mutans; Scanning; Sensitization, Immunologic; Sensitization, Immunological; Sialoglycosphingolipids; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stimulus; Stomach; Streptococcus mutans; Structure; Structure-Activity Relationship; Subcellular Process; Surface; System; System, LOINC Axis 4; T4 Cells; T4 Lymphocytes; TIL4; TLR protein; TLR2; TLR2 gene; TLR2 receptor; Technics, Imaging; Techniques; Time; Toll-Like Receptor 2; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin 1 Receptor-Like Protein 4; Toxic effect; Toxicities; Toxin; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urogenital; Urogenital System; Vaccines; Veiled Cells; accessory cell; adhesin; base; biological signal transduction; cell imaging; cellular imaging; chemical structure function; cultured cell line; cytokine; ganglioside, GD1a; gastric; gene product; helper T cell; host response; immunogen; immunoresponse; improved; in vivo; interdisciplinary collaboration; interest; lipid raft; microbial; monocyte; mouse model; mutant; new vaccines; next generation vaccines; novel; novel vaccines; oral immunity; oral pathogen; pathogen; programs; receptor; receptor expression; respiratory; response; social role; structure function relationship; trafficking; transcription factor; urogenital system (urinary part)",Oral Immunity and Adjuvant Receptors,,17138,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,5,346100,
7755040,R01,DE,5,,02/01/2010,01/31/2011,PA-04-157,5R01DE017315-05,,NIDCR:324543;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"LAMBERT, PAUL F;",1946942;,5R01DE017315,02/15/2006,01/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Alcohols; Anogenital cancer; Antirejection Therapy; Applications Grants; Buccal Cavity; Cancer Genes; Cancer of Cervix; Cancer of the Uterine Cervix; Cancer-Promoting Gene; Cancers; Cavitas Oris; Cervical Cancer; Cervix Cancer; Chemical Class, Alcohol; Clinical, Transplantation, Organ; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes, Viral; Genome; Grafting Procedure; Grant Proposals; Grants, Applications; HIV; HNSCC; HPV; HPV 16; HPV oncogene; HPV-16; HPV-High Risk; HPV16; HTLV-III; Head and Neck Carcinoma; Head and Neck Squamous Cell Carcinoma; Head and Neck, Buccal Cavity; High risk HPV; High risk Human Papillomavirus; High risk Human papilloma virus; Human; Human Immunodeficiency Viruses; Human Papillomavirus; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human papilloma viral oncogene; Human papilloma virus type 16; Human papilloma virus, type 16; Human papillomavirus 16; Human papillomavirus type 16; Human papillomavirus, type 16; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Immunosuppressive Therapy; Individual; Infection; Infectious Human Wart Virus; LAV-HTLV-III; Lesion; Lymphadenopathy-Associated Virus; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tonsillar Neoplasm; Malignant Tonsillar Tumor; Malignant Tumor; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Tumor of the Mouth; Malignant Tumor of the Tonsil; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of cervix uteri; Malignant neoplasm of mouth; Malignant neoplasm tonsil; Man (Taxonomy); Man, Modern; Molecular; Mouth; Mouth Cancer; Oncogenes; Oncogenic; Oral Cancer; Oral cavity; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Papilloma Virus, Human; Papillomavirus, Human; Phenotype; Profilings, Gene Expression; Progressive Disease; Risk; SCCHN; Therapeutic immunosuppression; Therapy, Anti-Rejection; Tobacco smoke; Tonsil Cancer; Tonsillar Cancer; Transcript Expression Analyses; Transcript Expression Analysis; Transforming Genes; Transplant Recipients; Transplantation Surgery; Viral Genes; Virus-HIV; artificial immunosuppression; biomarker; combinatorial; comparative; defined contribution; high risk; human papilloma virus 16; human papilloma virus oncogene; human papillomaviral oncogene; human papillomavirus oncogene; immunosuppressed patient; immunosuppression; malignancy; malignant mouth neoplasm; malignant tonsil neoplasm; mouse model; neoplasm/cancer; oral carcinogenesis; organ allograft; organ graft; organ xenograft; transplant patient; wart virus",Mouse Model for Human Papillomaviral (HPV)-associated Oral Cancer,,17315,AOIC,AIDS-associated Opportunistic Infections and Cancer Study Section,,5,324543,
7755039,R01,DE,5,,02/01/2010,01/31/2011,,5R01DE017413-04,,NIDCR:310563;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BOSTON,UNITED STATES,DENTISTRY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"GARLICK, JONATHAN A;",1892322;,5R01DE017413,02/05/2007,01/31/2012,"Basement membrane; Behavior; Biological; Biological Function; Biological Process; Biology; Biomedical Engineering; Body Tissues; Buccal Cavity; Buccal Mucosa; Cavitas Oris; Cell Communication and Signaling; Cell Signaling; Cells; Commit; Complex; Cues; Dentistry; Development; Differentiation and Growth; ES cell; Engineering; Engineerings; Epithelial; Epithelial Cells; Epithelium; Event; Extracellular Matrix Proteins; Face; Fibroblasts; Future; Generalized Growth; Generations; Goals; Growth; Head and Neck, Buccal Cavity; Human; Human, General; Intracellular Communication and Signaling; Investigators; Link; Man (Taxonomy); Man, Modern; Mediating; Membrane Proteins; Membrane-Associated Proteins; Mesenchymal; Molecular; Mother Cells; Mouth; Mouth Diseases; Mouth Mucosa; Mucosa; Mucosal Tissue; Mucous Membrane; Oral; Oral Cavity Disease; Oral Cavity Disorder; Oral Disease; Oral Disorder; Oral Mucosa; Oral cavity; Oral mucous membrane structure; Organ; Pattern; Phenotype; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Regenerative Medicine; Regulation; Research; Research Personnel; Research Proposals; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specific qualifier value; Specified; Staging; Stem cells; Structure; Surface Proteins; Technology; Testing; Therapeutic; Tissue Growth; Tissue Transplantation; Tissues; Transplantation; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; clinical applicability; clinical application; embryonic stem cell; facial; hESC; human ES cell; human ESC; human embryonic stem cell; in vivo; insight; keratinocyte; keratinocyte differentiation; mouth disorder; new approaches; new technology; novel; novel approaches; novel strategies; novel strategy; ontogeny; oral cavity epithelium; oral epithelia; oral epithelium; oral mucosae; oral mucosal; prevent; preventing; programs; regenerate new tissue; regenerating damaged tissue; regenerative; regenerative therapy; self-renewal; social role; stem cell biology; stem cell niche; stem cell of embryonic origin; success; tissue regeneration; transplant",Bioengineered Oral Mucosa from Embryonic Stem Cells for Regenerative Medicine,,17413,MTE,Musculoskeletal Tissue Engineering Study Section,,4,310563,
7761189,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE017684-03,,NIDCR:343035;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,LOS ANGELES,UNITED STATES,DENTISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"WANG, CUN-YU ;",2238597;,5R01DE017684,02/20/2008,01/31/2012,"4-Carboxyglutamic Protein, Bone; ATF; Affect; Antimorphic mutation; Arthritis, Degenerative; Assay; Atrophic Arthritis; BMP-3; BMP-3A; BMP3; Bioassay; Biologic Assays; Biological Assay; Blotting, Western; Body Tissues; Bone; Bone Density; Bone Diseases; Bone Diseases, Metabolic; Bone Formation; Bone Formation Inhibition; Bone Mineral Density; Bone Morphogenetic Protein 3; Bone Morphogenetic Protein 3 (Osteogenic); Bone Morphogenetic Proteins; Bone Regeneration; Bone Resorption; Bone Tissue; Bone and Bones; Bone gamma-Carboxyglutamic Acid Protein; Bones and Bone Tissue; CHIP assay; Cachectin; Cachectin-Tumor Necrosis Factor; Calcium-Binding Protein, Vitamin K-Dependent; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Process; Cell Signaling; Cell model; Cell physiology; Cell surface; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular model; ChIP (chromatin immunoprecipitation); Chronic; Chronic Periodontitis; Collagen; Defect; Degenerative polyarthritis; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Event; Exhibits; GFAC; Gene Transcription; Genetic Transcription; Gla Protein, Bone; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; I Kappa B A; I Kappa B-Alpha; I kappa B-alpha protein; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IL-1; IL1; INFLM; IkappaBalpha; Immune Function, Cellular; Immunoglobulin Enhancer-Binding Protein; In Vitro; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Arthritis; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; Lymphocyte-Stimulating Hormone; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; Macrophage Cell Factor; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Man (Taxonomy); Man, Modern; Mediating; Mesenchymal; Metabolic Bone Diseases; Metabolic disorder of bone; Mice, Transgenic; Modeling; Molecular; NDUL; NF-Kappa B Inhibitor Alpha; NF-kB; NF-kappa B; NF-kappaB; NF-kappaB inhibitor alpha; NFKB; NFKBI; NFKBIA; Nodule; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Nuclear Transcription Factor NF-kB; Nucleus; Oophorectomy; Osteoarthritis; Osteoarthrosis; Osteoblasts; Osteocalcin; Osteoclastic Bone Loss; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; Periodontitis; Play; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA Expression; RNA, Small Interfering; RT-PCR; RTPCR; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Regulation; Reverse Transcriptase Polymerase Chain Reaction; Rheumatoid Arthritis; Roentgen Rays; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Subcellular Process; T Helper Factor; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Therapeutic; Time; Tissues; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Factor NF-kB; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenic Mice; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Vitamin K-Dependent Bone Protein; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; Work; X-Radiation; X-Rays; Xrays; abstracting; activating transcription factor; base; biological signal transduction; bone; bone disorder; bone loss; bone metabolism disorder; bone morphogenic protein 3; bone repair; chromatin immunoprecipitation; cultured cell line; cytokine; degenerative joint disease; disease/disorder; female gonadectomy; hypertrophic arthritis; immune function; in vivo; inhibitor; inhibitor/antagonist; injured; insight; kappa B Enhancer Binding Protein; knock-down; lymphocyte activating factor; metabolic bone disease; morphometry; novel; nuclear factor kappa beta; osteoblast differentiation; osteogenic; osteogenin; p40 protein (IkappaB-alpha); postnatal; prevent; preventing; protein blotting; regenerate new tissue; regenerating damaged tissue; reverse transcriptase PCR; siRNA; small molecule; social role; tissue regeneration; tomography; transcription factor; tumor necrosis factor (unspecified)",Inhibition of Bone Formation by TNF/NF-kappa B Signaling,,17684,SBSR,Skeletal Biology Structure and Regeneration Study Section,,3,343035,
7772339,R01,DE,5,,04/01/2010,03/31/2011,PA-07-070,5R01DE017974-03,,NIDCR:259875;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BALTIMORE,UNITED STATES,DENTISTRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"XU, HUAKUN ;",2097609;,5R01DE017974,04/01/2008,03/31/2012,"Accounting; Acids; Age; Area; Bone Tissue; Ca(4)(PO(4))(2)O; CaHPO(4); CaHPO4; Calcium Fluoride; Calcium fluoride (CaF2); Caries; Clinical; Composite Resins; DCPA; Dental; Dental Decay; Dental Materials; Dental caries; Dentistry; Development; Equation; Esthetics; FLR; Failure (biologic function); Filler; Fluorides; Fracture; Generations; Glass; Goals; Human; Human, General; Hydrogen Oxide; In Vitro; Ions; Laboratories; Load-Bearing; Loadbearing; Man (Taxonomy); Man, Modern; Measures; Mechanics; Methods; Minerals; Modeling; Outcome; Particle Size; Performance; Plant Resins; Process; Property; Property, LOINC Axis 2; Psychological reinforcement; Reinforcement; Reinforcement (Psychology); Research; Resins, Plant; Resistance; Series; Solutions; Stress; Structure; Surface; Testing; Time; Tissue Engineering; Tooth; Tooth structure; Vitremer; Vitremer luting cement; Water; Weight-Bearing; Weight-Bearing state; Weightbearing; Work; abstracting; acid stress; bone fracture; calcium phosphate; controlled release; cost; dental resin; design; designing; dibasic calcium phosphate, anhydrous; dicalcium phosphate anhydrous; dimethyl 2,3,5,6-tetrachloro-terephthalate; dimethyl 2,3,5,6-tetrachloroterephthalate; engineered tissue; failure; fighting; glass ionomer; improved; mono-calcium phosphate; monocalcium phosphate; nano; nano composite; nano materials; nano particle; nanocomposite; nanomaterials; nanoparticle; next generation; novel; particle; prevent; preventing; resin; resistant; response; restoration; teeth; tetracalcium phosphate; tooth decay","Development of high performance, caries-inhibiting dental nano-materials",,17974,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,3,259875,
7755863,R01,DE,5,,02/01/2010,01/31/2011,PA-07-169,5R01DE018138-03,,NIDCR:321940;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,RICHMOND,UNITED STATES,DENTISTRY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"XU, PING ;",7128922;,5R01DE018138,03/17/2008,01/31/2013,"Animal Model; Animal Models and Related Studies; Antibody Formation; Antibody Production; Antibody Response; Bacteria; Band Shift Mobility Assay; Bandshift Mobility Assay; Benign; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Bioinformatics; Blotting, Western; Body Tissues; Buccal Cavity; Caries; Cavitas Oris; Code; Coding System; Column Chromatography; Combining Site; Communities; Computer Simulation; Computerized Models; Consensus; Cytofluorometry, Flow; D. pneumoniae; D.pneumoniae; DNA Binding; DNA Binding Interaction; Dental Decay; Dental caries; Development; Diplococcus pneumoniae; Electrophoretic Mobility Shift Assay; Employee Strikes; Endocarditis; Evolution; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Proteins; Gene Regulation; Gene Regulation Process; Gene Transcription; Gene Transfer; GeneHomolog; Genes; Genetic Transcription; Genetics-Mutagenesis; Genome; Genomics; Goals; Head and Neck, Buccal Cavity; Heart; Homolog; Homologous Gene; Homologue; Human; Human, General; Immunotherapeutic agent; Infection; Infective endocarditis; Ligands; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Membrane Proteins; Membrane-Associated Proteins; Microfluorometry, Flow; Mobility Shift Assay; Models, Computer; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Mouth; Mutagenesis; Operon; Oral; Oral cavity; Pathogenicity Factors; Pneumococcus; Protein Gene Products; Proteins; RNA Expression; Reactive Site; Regulation; Regulon; Reporting; S. mutans; S. pneumoniae; S. pyogenes; S.mutans; S.pyogenes; Simulation, Computer based; Streptococcus; Streptococcus Group A; Streptococcus mutans; Streptococcus pneumoniae; Streptococcus pyogenes; Strikes; Strikes, Employee; Surface; Surface Proteins; Time; Tissues; Tooth; Tooth structure; Transcription; Transcription, Genetic; Virulence; Virulence Factors; Western Blotting; Western Blottings; Western Immunoblotting; antibody biosynthesis; base; comparative genomics; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; experiment; experimental research; experimental study; fitness; flow cytophotometry; gel shift assay; gene function; gene product; immunoglobulin biosynthesis; immunologic preparation; immunotherapeutics; improved; in silico; microbial; model organism; mutant; oral streptococci; pathogen; prevent; preventing; protein blotting; protein expression; research study; teeth; tooth decay; transfer of a gene; virtual simulation",Regulation Of Fitness And Virulence In Oral Streptococci,,18138,ZRG1,Special Emphasis Panel,,3,321940,
7760622,R01,DE,5,,02/01/2010,01/31/2011,DE-07-004,5R01DE018290-05,,NIDCR:332163;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,CHARLESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"KIRKWOOD, KEITH L;",1865020;,5R01DE018290,02/07/2007,01/31/2012,"21+ years old; 3' Untranslated Regions; 3'UTR; A. actinomycetemcomitans; ATP-protein phosphotransferase; Abbreviations; Acid Phosphatase; Actinobacillus actinomycetemcomitans; Acute; Address; Adenosine; Adult; Alveolar Bone Loss; Alveolar Resorption; Assay; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BRF Gene; BRF1; BRF1 gene; BRF2; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bacterium actinomycetem comitans; Bacterium comitans; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Bone; Bone Marrow; Bone and Bones; Bones and Bone Tissue; Butyrate Response Factor 2; CAT Scan, X-Ray; CAT scan; COX-2; COX-2 protein; COX2; COX2 enzyme; CSBP1; CSBP2; CSPB1; CT X Ray; CT scan; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Chronic; Chronic Periodontitis; Common Rat Strains; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Cyclo-Oxygenase-2; Cyclooxygenase; Cytokines and Inflammatory Response; Data; Development; Differentiation Factor, B-Cell; Dinoprostone; Disease; Disease Progression; Disorder; EC 2.7; EC 2.7.2-; EGF-Response Factor 2; EGF-response factor 2 protein, human; EMI scan; ERF-2 Protein; ERF-2 protein, human; ERF2; ERK MAP Kinases; EXIP; Elements; Experimental Models; Experimental Models, Other; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Family; G0-G1 switch regulatory protein 24; GFP; GM-CSF; GMCSF; GOS24 protein; Gene Targeting; General Transcription Factor 3B, 90-kD Subunit; Generalized Growth; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Green Fluorescent Proteins; Growth; HPGF; Hepatocyte-Stimulating Factor; Histamine-Producing Cell-Stimulating Factor; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IHC; IL-6; IL6 Protein; INFLM; Immune; Immune response; Immunoglobulin Enhancer-Binding Protein; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Inflammatory Response Pathway; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Interleukins; Intracellular Communication and Signaling; Investigators; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; Kinases; LPS; Ligand Binding Protein; Lipopolysaccharides; MAP Kinase 8; MAP Kinase 8 Gene; MAP Kinase Gene; MAP kinase; MAPK; MAPK phosphatase; MAPK14; MAPK14 gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MGI-2; MMP-13; MMP-13 gene product; MMP13 gene product; MMPs; Mammals, Mice; Mammals, Rats; Matrix Metalloproteinases; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinases; Modeling; Models, Experimental; Molecular; Molgramostin; Murine; Mus; Mxi2; Myeloid Differentiation-Inducing Protein; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nature; NuP475 protein; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; ODF; OPGL; Oral; Organism; Orthophosphoric-monoester phosphohydrolase (acid optimum); Osteoclasts; PGE2; PGE2 alpha; PGE2alpha; PGG/HS; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PHS-2; PRKM14; PRKM15; PRKM8; PTGS2; PTGS2 gene; Parodontosis; Pathway interactions; Periodontal Bone Loss; Periodontal Diseases; Periodontal Resorption; Periodontitis; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Plasmacytoma Growth Factor; Play; Process; Production; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Kinase; Protein Phosphorylation; RANKL; Rat; Rattus; Receptor Protein; Regulation; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Bone Marrow; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SAPK2A; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stability, mRNA; Stress; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; System; System, LOINC Axis 4; TAF3B2 Gene; TAF3C, Formerly; TC-GM-CSF; TFIIIB90 Gene; TIS11 protein; TIS11D; TIS11D Protein; TIS11b protein; TLR protein; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TNFSF11; TNFSF11 gene; TTP protein; Targetings, Gene; Threonine/Tyrosine Protein Kinase; Tissue Growth; Tissues; Toll-like receptors; Tomodensitometry; Tomography, Xray Computed; Transcription Factor NF-kB; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumor-Cell Human GM Colony-Stimulating Factor; Urd; Uridine; Wild Type Mouse; X-Ray Computed Tomography; ZFP36 protein; ZFP36L2; ZFP36L2 gene; ZFP36L2 protein, human; Zinc Finger Protein 36 C3H Type-Like 2; adult human (21+); attenuation; base; biological signal transduction; bone; bone loss; butyrate response factor 1; butyrate response factor 2 protein, human; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cMG1 protein; catscan; collagenase 3; computed axial tomography; computerized axial tomography; computerized tomography; cyclo-oxygenase II; cyclooxygenase 2; cytokine; disease/disorder; extracellular signal related kinase; fetal; glycogen synthase a kinase; granulocyte macrophage colony stimulating factor; hCOX-2; hRANKL2; host response; human ZFP36L2 protein; hydroxyalkyl protein kinase; immunoresponse; in vivo; interferon beta 2; jun-NH2-Terminal Kinase; kappa B Enhancer Binding Protein; living system; mRNA Expression; mRNA Stability; macrophage; matrix metalloproteinase-13; mitogen-activated protein kinase p38; nuclear factor kappa beta; ontogeny; oral pathogen; osteoclastogenesis; p38; p38 MAP Kinase; p38 MAPK; p38 MAPK Gene; p38 Protein Kinase; p38 SAPK; p38Alpha; pathogen; pathway; periodontal disorder; periodontium disease; periodontium disorder; phosphorylase b kinase kinase; programs; prostaglandin H synthase-2; prototype; receptor; resistant; response; sOdf; social role; stress-activated protein kinase 1; tristetraprolin; tumor necrosis factor (unspecified); unspecified interleukin; zinc finger protein 36, C3H type-like 2 protein, human",Negative Regulation of Innate Immune Responses through MAPK Phosphatases,,18290,ZDE1,Special Emphasis Panel,,5,332163,
7761657,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE018500-03,,NIDCR:529959;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,UNIVERSITY PARK,UNITED STATES,SOCIAL SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"RICHTSMEIER, JOAN THERESE;",2091289;,5R01DE018500,03/10/2008,01/31/2013,"3-D analysis; 3-dimensional analysis; 3D analysis; ATP[{..}]protein-tyrosine O-phosphotransferase; Affect; Age; Anatomic; Anatomical Sciences; Anatomy; Apert syndrome; Apert-Crouzon syndrome; Apoptosis; Apoptosis Pathway; Archives; Binding; Binding (Molecular Function); Biological; Biomechanics; Body Tissues; Bone; Bone and Bones; Bone structure of cranium; Bones and Bone Tissue; Brain; Calvaria; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cephalic; Characteristics; Clinical; Cranial; Cranial Sutures; Craniofacial Dysostosis; Craniosynostosis; Cranium; Crouzon's Disease; Crouzons Disease; Data; Development; Developmental Process; Disease; Disorder; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Elements; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Embryonic Tissue; Encephalon; Encephalons; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Event; FGF-1 receptor tyrosine kinase; FGF-R; FGFR; FGFR-1; FGFR1; FGFR1 protein; FGFR1 tyrosine kinase; Fibroblast Growth Factor Receptor 1; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Gene Organization; Gene Structure; Gene Structure/Organization; Genetic; Genetic Alteration; Genetic Change; Genetic Processes; Genetic defect; Genotype; HEK3; Head; Human; Human, General; Image; Infant; Intracellular Communication and Signaling; Investigation; Joint structure of suture of skull; Knowledge; Lead; Ligands; Literature; Live Birth; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Meninges; Mice; Mice, Mutant Strains; Molecular; Molecular Interaction; Morphology; Motility; Motility, Cellular; Murine; Mus; Mutant Strains Mice; Mutation; NMR Imaging; NMR Tomography; Nature; Nervous; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; PTK; Pathway interactions; Pattern; Pb element; Perinatal; Pfeiffer Syndrome; Phenotype; Play; Population; Position; Positioning Attribute; Process; Production; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Receptors, FGF; Research; Research Design; Research Resources; Resources; Role; Sampling; Science of Anatomy; Series; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skull; Staging; Study Type; Subcellular Process; Surgical sutures; Sutures; Syndrome; Syndrome, Pfeiffer; System; System, LOINC Axis 4; Testing; Three-dimensional analysis; Time; Tissues; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; Work; Zeugmatography; anatomy; base; biological signal transduction; bone; brain shape; calvarial; cell motility; craniofacial; craniofacies; cranium; crouzon disease; crouzon syndrome; data modeling; developmental genetics; disease/disorder; embryo tissue; genome mutation; heavy metal Pb; heavy metal lead; human data; hydroxyaryl protein kinase; imaging; malformation; mouse model; mouse mutant; mutant; neural; pathway; postnatal; premature; relating to nervous system; social role; spatiotemporal; study design; suture fusion; synostosis (cranial); trait; tyrosyl protein kinase",PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS,,18500,SBDD,Skeletal Biology Development and Disease Study Section,,3,529959,
7786213,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE018893-02,,NIDCR:362588;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,OKLAHOMA CITY,UNITED STATES,NONE,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"MERRITT, JUSTIN ;",6728873;,5R01DE018893,03/12/2009,01/31/2014,"Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-; Acids; Address; Affect; Assay; Bacterial Infections; Bacteriophage lambda; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blotting, Western; CHIP assay; Caries; Cats; Cell Communication and Signaling; Cell Signaling; ChIP (chromatin immunoprecipitation); Characteristics; Chloramphenicol; Chloramphenicol Resistance; Chloramphenicol Resistant; Coliphage lambda; Combining Site; Competence; DNA Alteration; DNA Binding; DNA Binding Interaction; DNA mutation; Data; Dental Decay; Dental Plaque; Dental caries; Disease; Disorder; Domestic Cats; E coli; Engineering; Engineerings; Enterobacteria phage lambda; Escherichia coli; Esteroproteases; Exhibits; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Future; Gene Action Regulation; Gene Alteration; Gene Expression; Gene Expression Regulation; Gene Mutation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genes, Regulator; Genetic; Genetic Algorithm; Genetic Alteration; Genetic Change; Genetic Programming; Genetic Transcription; Genetic analyses; Genetic defect; Genetic mutation; Genome; Genomics; Goals; Human; Human, General; In Vitro; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Intercistronic Region; Intracellular Communication and Signaling; Libraries; Link; Mammals, Cats; Man (Taxonomy); Man, Modern; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Microbial Biofilms; Modeling; Molecular Interaction; Mutation; Mutation Analysis; Organism; Pathogenesis; Pathogenicity; Pathogenicity Factors; Pathway interactions; Peptidases; Peptide Hydrolases; Phage lambda; Phenotype; Post-Translational Regulation; Posttranslational Regulation; Production; Proteases; Proteinases; Proteins; Proteolytic Enzymes; RNA Expression; Reactive Site; Regions, Intergenic; Regulation; Regulator Genes; Regulatory Pathway; Regulatory Protein; Regulon; Reporter; Repression; Research; Role; S. mutans; S.mutans; Sampling; Sensory; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slide; Streptococcus mutans; Stress; System; System, LOINC Axis 4; Targetings, Gene; Technology; Testing; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Transducers; Translating; Translatings; Virulence; Virulence Factors; Western Blotting; Western Blottings; Western Immunoblotting; Work; bacterial disease; bacteriocin; base; biofilm; biological adaptation to stress; biological signal transduction; chromatin immunoprecipitation; design; designing; disease/disorder; gene product; genetic analysis; genetic regulatory protein; genome mutation; in vivo; insight; language translation; living system; member; mutant; novel; oral biofilm; paralog; paralogous gene; pathway; protein blotting; public health relevance; reaction; crisis; regulatory gene; regulatory gene product; response; social role; stress response; stress tolerance; stress; reaction; tooth decay; trans acting element; transcription factor; treatment strategy",The irvA-dependent pathway: a link between stress adaptation and virulence," Project Narrative Dental caries is the most common human bacterial disease and is largely correlated with the overgrowth of Streptococcus mutans. Since this organism's ability to cause disease requires careful coordination of its stress response and virulence, these studies may yield novel treatment strategies to control the pathogenesis of S. mutans.",18893,ODCS,"Oral, Dental and Craniofacial Sciences Study Section",,2,362588,
7778363,R01,DE,5,,02/01/2010,01/31/2011,PA-07-070,5R01DE019203-02,,NIDCR:351450;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,NEW ORLEANS,UNITED STATES,DENTISTRY,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"XU, XIAOMING ;",3083352;,5R01DE019203,03/01/2009,01/31/2013,"0-11 years old; Accounting; Adhesives; Adopted; Aged 65 and Over; Animals; Anti-Bacterial Agents; Antibacterial Agents; Area; Asialia; Asialias; Bacteria; Care, Health; Caries; Caries prevention; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Complex; Compomers; Composite Dental Resin; Dental; Dental Bonding; Dental Decay; Dental Enamel; Dental Materials; Dental caries; Dentists; Development; Diabetes Mellitus; Drug Formulations; Drugs; Economics; Elderly; Elderly, over 65; Enamel; Extravasation; Fear; Filler; Fluorides; Formulation; Formulations, Drug; Fright; Future; Generalized Growth; Generations; Glass; Goals; Growth; Head and Neck; Head and neck structure; Healthcare; Human; Human, Child; Human, General; Hyposalivation; Hyposalivations; In Vitro; Investigation; L-Lysine; L. casei; L.casei; Lactic acid; Lactobacillus casei; Lead; Leakage; Length of Life; Lesion; Longevity; Lysine; Man (Taxonomy); Man, Modern; Mechanics; Medication; Microbial Biofilms; Modeling; Mouth Dryness; Oral health; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physically Challenged; Plant Resins; Polyacid-Modified Composite Resins; Population; Property; Property, LOINC Axis 2; QOL; Quality of life; Recurrence; Recurrent; Resins, Plant; Risk; S. mutans; S.mutans; Saccharose; Series; Sjogren's Syndrome; Sjogrens; Spillage; Streptococcus mutans; Structure; Sucrose; Syndrome; System; System, LOINC Axis 4; Testing; Tissue Growth; Tooth; Tooth structure; Vulnerable Populations; Xerostomia; Xerostomias; Zirconium; Zr element; advanced age; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; ammonium fluoride; anti-bacterial; anti-microbial; antibacterial; antimicrobial; aptyalism; base; biocompatibility; biofilm; biomaterial compatibility; calcium phosphate; children; clinical investigation; dental health; diabetes; diabetic; drug/agent; dry mouth; elders; geriatric; heavy metal Pb; heavy metal lead; high risk; improved; irradiation; late life; later life; life span; lifespan; microleakage; monomer; novel; older adult; older person; ontogeny; pandemic; pandemic disease; prevent; preventing; prevention of dental caries; remineralization; resin; restoration; restorative material; scale up; seal; senior citizen; teeth; tooth decay; tooth enamel; youngster; zirconia; zirconium dioxide; zirconium oxide",Novel Antibacterial Fluoride-releasing Dental Materials," This project seeks to develop a series of antibacterial, fluoride-releasing, and bioactive dental materials. These materials are expected to have enhanced anti-caries efficacy over existing resin-based dental materials. The development of these materials has the potential to make a huge impact on oral health care and oral health quality-of-life, in particular for the vast number of high-caries-risk patients (medically compromised who suffer from xerostomia or dry mouth, children, elderly, mentally or physically challenged).",19203,BMBI,Biomaterials and Biointerfaces Study Section,,2,351450,
7743086,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK019514-30,,NIDDK:298692;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"RUDERMAN, NEIL B;",1869154;,5R01DK019514,06/01/1979,11/30/2010,"4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; AMP-PK reactivator; AMP-activated protein kinase kinase; AMPK kinase; Abscission; Accounting; Adipocytes; Adipose Cell; Adipose tissue; Antibodies; Antidiabetic Hormone; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Biochemical; Body Tissues; Catecholamines; Cell Communication and Signaling; Cell Signaling; Cells; Chemotherapy-Hormones/Steroids; Coenzyme A, S-(hydrogen propanedioate); Common Rat Strains; D-Glucose; Data; Dextrose; Differentiation Factor, B-Cell; Endocrine Gland Secretion; Enzymes; Excision; Exercise; Exercise, Physical; Extirpation; Fat Cells; Fatty Tissue; GCG; Glucagon; Glucagon (1-29); Glucose; Glukagon; Glycogen; Grant; HG-Factor; HMG CoA reductase kinase kinase; HPGF; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hepatocyte-Stimulating Factor; Hormonal; Hormones; Humulin R; Hybridoma Growth Factor; Hyperglycemic-Glycogenolytic Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; In Vitro; Incubated; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; Isoprenaline; Isopropyl Noradrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isuprel; LKB1; LKB1/STK11 Gene; Link; Lipocytes; Lipolysis; Liver; Liver Cells; METBL; MGI-2; Malonyl CoA; Malonyl Coenzyme A; Mammals, Rats; Mature Lipocyte; Mature fat cell; Metabolic Processes; Metabolic syndrome; Metabolism; Microscope; Microscopic; Mitochondria; Modeling; Molecular Interaction; Muscle; Muscle Tissue; Myeloid Differentiation-Inducing Protein; Novolin R; Nutrient; Nutritional; Oxidation-Reduction; PJS; Pathogenesis; Phosphorylation; Phosphorylation Site; Plasmacytoma Growth Factor; Preparation; Prevention; Process; Protein Isoforms; Protein Phosphorylation; Public Health; Rat; Rattus; Redox; Regulation; Removal; Reporting; STK11; STK11 gene; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Starvation; Surgical Removal; Sympathins; Testing; Therapeutic Hormone; Tissues; abstracting; adipose; base; biological signal transduction; body system, hepatic; hormonal regulation; hormone regulation; in vivo; interferon beta 2; malonyl-CoA decarboxylase; malonyl-coenzyme A decarboxylase; mitochondrial; novel; organ system, hepatic; oxidant stress; oxidation reduction reaction; prevent; preventing; public health medicine (field); resection; white adipose tissue; yellow adipose tissue",Nutrient and Hormonal Regulations of AMPK and Malonyl CoA,,19514,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,30,298692,
7749954,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK019974-32,,NIDDK:354851;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PHARMACOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"HINKLE, PATRICIA M.;",1959294;,5R01DK019974,07/01/1999,12/31/2011,"5-Oxo-L-prolyl-L-histidyl-L-prolinamide; Acute; Address; Adenohypophysis; Animals; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Antibodies; Arrestins; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Bolus; Bolus Infusion; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chemotherapy-Hormones/Steroids; Common Rat Strains; Cultured Cells; Cytoplasmic Membrane; Dephosphorylation; Dimerization; Dissociation; EC 2.7; ELISA; Endocrine Gland Secretion; Endocytic Vesicle; Endocytosis; Endocytotic Vesicle; Endosomes; Enzyme-Linked Immunosorbent Assay; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Goals; Head and Neck, Thyroid; Hormones; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Intracellular Communication and Signaling; Kinases; Knockout Mice; LTH; Label; Lactogenic Hormone, Pituitary; Learning; Mammals, Rats; Mammotropic Hormone, Pituitary; Mammotropin; Measures; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Mole the mammal; Molecular Interaction; Moles; Mutate; Nervous System, Pituitary; Null Mouse; Nutrition; Nutritional Science; Organelles; Output; PRL; PRL (Prolactin); Pars Anterior Pituitary Gland; Pathway interactions; Pattern; Phosphates; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiologic pulse; Physiological; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Plasma Membrane; Prolactin; Protein Dephosphorylation; Protein Dimerization; Protein Phosphorylation; Protirelin; Protyreline; Pulse; Pyr-His-ProNH2; Rat; Rattus; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, Protirelin; Receptors, Thyrotropin-Releasing Hormone; Receptosomes; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Recycling; Role; Science of nutrition; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Staining method; Stainings; Stains; Surface; TRH; TRH Receptors; Techniques; Temperature; Testing; Therapeutic Hormone; Thyreotropin; Thyroid; Thyroid Gland; Thyroid Stimulating Hormone; Thyroid-Releasing Hormone; Thyroid-Stimulating Hormone; Thyroliberin Receptors; Thyrotropin; Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone Receptors; Tissues; Transphosphorylases; arr3; arrestin 3; arrestin3; beta-arrestin; biological signal transduction; desensitization; experiment; experimental research; experimental study; hypothalamic; immunocytochemistry; in vivo; inorganic phosphate; luteotropic hormone; luteotropin; mutant; nutrition; pathway; plasmalemma; receptor; receptor internalization; receptor recycling; research study; response; social role; stoichiometry; trafficking",Modulation of Receptor Number in Cultured Cells,,19974,MCE,Molecular and Cellular Endocrinology Study Section,,32,354851,
7760905,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK025836-26,,NIDDK:283312;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,BIOCHEMISTRY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"LEVY, DANIEL S;",1905793;,5R01DK025836,08/01/1979,01/31/2011,"3' Untranslated Regions; 3'UTR; 5' Flanking Region; 5' Flanking Sequence; Acids, Bile; Affect; Agonist; Amish; Antibodies; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Bile Acids; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Blood Serum; Blotting, Western; CHIP assay; Cancer Causing Agents; Cancers; Carcinogens; Carrier Proteins; Causality; Cells; ChIP (chromatin immunoprecipitation); Code; Coding System; DNA Sequence Analysis; Defect; Disease; Disorder; Drug Metabolic Detoxication; EC 3.3.2.3; EPHX; EPHX1; EPHX1 gene; EPOX; Electrons; Electrophoretic Mobility Shift Assay; Endogenous Factors; Endoplasmic Reticulum; Epoxide Hydrases; Epoxide Hydratases; Epoxide Hydrolase 1; Epoxide Hydroxylase 1, Microsomal; Epoxide Hydroxylase 1, Microsomal (Xenobiotic); Epoxide hydrolase; Ergastoplasm; Etiology; Exogenous Factors; Exons; Fibrates; Funding; Gene Transcription; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic Transcription; Genetic defect; Genomics; Genotype; Glucuronides; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Human; Human, General; Hydrocarbons; Hydrolase Family Gene; Hydrolase Gene; Individual; Intermediary Metabolism; Intervening Sequences; Introns; Investigators; Knockout Mice; Knowledge; Label; Laboratories; Linkage Analysis; Liquid Chromatography; Liver Cells; Liver diseases; MEH; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Transport; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Mice, Knock-out; Mice, Knockout; Microsomal Epoxide Hydrolase; Mobility Shift Assay; Molecular Interaction; Mutagenesis, Site-Directed; Mutation; Na element; Negative Beta Particle; Negatrons; Nuclear Receptors; Null Mouse; Oncogens; Organism-Level Process; Organismal Process; PPAR alpha; PPARalpha; Peroxisome Proliferator-Activated Receptor alpha; Physiologic Processes; Physiological Processes; Plasma; Play; Poisons; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Procedures; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; RNA Splicing; Radiolabeled; Regulation; Regulatory Element; RegulatoryElement; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; Sequence Analyses, DNA; Sequence Analysis, DNA; Serum; Serum, Plasma; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium; Splicing; Susceptibility; Targeted DNA Modification; Targeted Modification; Technology; Toxic Chemical; Toxic Substance; Transcription; Transcription, Genetic; Transfection; Translations; Transmembrane Transport; Transport Proteins; Transporter Protein; UDP Glucuronic Acid; UDPGA; Uridine Diphosphate Glucuronic Acid; Uridine Diphosphoglucuronic Acid; Urinary System, Urine; Urine; Western Blotting; Western Blottings; Western Immunoblotting; Xenobiotic Metabolism; Xenobiotics; alpha-D-Glucopyranuronic acid, 1-P'-ester with uridine 5'-(trihydrogen diphosphate); chromatin immunoprecipitation; deletion analysis; detoxification; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; expression vector; family based linkage study; gel shift assay; gene product; genetic linkage analyses; genetic linkage analysis; genome mutation; hepatopathy; kindred; linkage analyses; liver disorder; malignancy; membrane structure; neoplasm/cancer; poison; polymorphism; programs; protein blotting; radiolabel; radiotracer; social role; tandem mass spectrometry; toxic compound; transcription factor; uptake",Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase,,25836,HBPP,Hepatobiliary Pathophysiology Study Section,,26,283312,
7652510,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK029857-27,,NIDDK:194668;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"WEINSTEIN, ALAN M;",1903820;,5R01DK029857,08/01/1981,12/31/2010,"ATP phosphohydrolase; ATP phosphohydrolase (H+/K+-transporting); ATPase; Acid-Base Balance; Acid-Base Equilibrium; Acidosis; Acids; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Alkalosis; Ammonia; Ammonium; Autoregulation; Barter's Disease; Bartter Disease; Bartter Syndrome; Bartter syndrome (BS); Brush Border; Cell Communication and Signaling; Cell Signaling; Cell Volumes; Cell model; Cells; Cellular model; Collaborations; Computer Simulation; Computerized Models; Convection; Defect; Disease; Disorder; Distal; Distal Convoluted Tubule; Distal convoluted renal tubule structure; Diuresis; Duct; Duct (organ) structure; Dysfunction; Electrolyte Disorder; Electrolytes; Environment; Epithelium; Excretory function; Extremities; Functional disorder; Genetic Condition; Genetic Diseases; H(+)-K(+)-Exchanging ATPase; H(+)-K(+)-Transporting ATPase; H+ K+ ATPase; H+ element; Hereditary Disease; Homeostasis; Hydrogen Ions; Hydrogen Oxide; Hydrogen, Potassium ATPase; Hydrogen, Potassium, Adenosine Triphosphatase; Hydrogen, Potassium, Adenosinetriphosphatase; Hyperkalemias; Hyperpotassemia; Hypoaldosteronism; Intermediary Metabolism; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Investments; K element; Kidney; Kidney Tubules; Kidney Tubules, Distal; Kinetic; Kinetics; Libraries; Limb structure; Limbs; Liquid substance; METBL; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Membrane; Metabolic; Metabolic Processes; Metabolism; Microvillus; Modeling; Models, Computer; Modification; Molecular; Molecular Disease; NHE-2; NHE-2 protein; Na element; Na-H exchanger 2; Nephrons; Non-Trunk; Occluding Junctions; Organ; Pattern; Physiological Homeostasis; Physiopathology; Potassium; Process; Programs (PT); Programs [Publication Type]; Protons; Recovery; Recycling; Renal function; Renal tubule structure; Research Personnel; Researchers; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; Sodium; Specific qualifier value; Specified; Striated Border; Testing; Thick; Thickness; Tight Junctions; Time; Tubular; Tubular formation; Urinary System, Kidney; Urinary System, Urine; Urine; Uriniferous Tube; Volumes, Cell; Water; Work; Zonula Occludens; aldosteronism-normal blood pressure syndrome; base; biological signal transduction; cellular microvillus; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cost; disease/disorder; excretion; fluid; genetic disorder; hereditary disorder; hydrogen potassium exchanging ATPase; hyperkalemia; in silico; interstitial; interventional strategy; juxtaglomerular hyperplasia syndrome; kidney function; liquid; mathematical model; mathematical modeling; membrane structure; pathophysiology; programs; renal; renal tubule; sensor; simulation; sodium-hydrogen exchanger 2; solute; theories; thiazide; uptake; virtual simulation",Theory of Solute and Water Transport Across Epithelia,,29857,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,27,194668,
7762701,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK030111-28,,NIDDK:382348;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STONY BROOK,UNITED STATES,PHARMACOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"MALBON, CRAIG C;",1886039;,5R01DK030111,08/01/1981,01/31/2011,"A kinase anchoring protein; AKAP; ATP-protein phosphotransferase; Address; Affinity; Affinity Chromatography; Animals; Antimorphic mutation; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Bioluminescence; Birth Defects; Body Tissues; Bone Formation; Brachydanio rerio; Cancers; Cell Communication and Signaling; Cell Fractionation; Cell Polarity; Cell Signaling; Cell membrane; Cells; Chimera Protein; Chimeric Proteins; Chromatography, Affinity; Chromosome Mapping; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Coupled; Critiques; Culturing, in vitro Vertebrate, Primary; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoplasmic Membrane; Danio rerio; Data; Development; Digestion; Disadvantaged; Docking; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drosophila; Drosophila genus; EC 2.7; ES cell; Editorial Comment; Editorial Comment (PT); Elements; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endoderm; Energy Transfer; Engineering; Engineerings; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Event; Family member; Figs; Figs - dietary; Flies; Fluorescence; Fluorescence Microscopy; Fruit Fly, Drosophila; Fusion Protein; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gel; Gene Action Regulation; Gene Expression Regulation; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetics, Gene Mapping; Genetics-Mutagenesis; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); HSP; Heat shock proteins; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Image; Immunoblot Analysis; Immunoblotting; In Vitro; Individual; Ink; Intracellular Communication and Signaling; Investigators; Isoforms; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; Knockout Mice; Laboratories; Lead; Life; Linkage Mapping; Literature; Locales; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Maps; Mass Spectrum; Mass Spectrum Analysis; Measurement; Measures; Mediating; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mixed Embryonal Carcinoma and Teratoma; Modeling; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Genetic Abnormality; Molecular Interaction; Mouse Strains; Murine; Mus; Mutagenesis; Mutation; Noise; Nuclear; Null Mouse; Osteogenesis; Outcome; PKG; PRKM8; Pathway interactions; Pb element; Peptide Fingerprinting; Peptide Mapping; Peptides; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Photons; Plasma Membrane; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Cell Cultures; Process; Protein Binding; Protein Binding Domain; Protein Binding Motif; Protein Family; Protein Isoforms; Protein Kinase; Protein Kinase G; Protein Modification; Protein Modification, Post-Translational; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein phosphatase; Protein-Protein Interaction Domain; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteomics; Published Comment; Publishing; R01 Mechanism; R01 Program; RNA Expression; RNA, Small Interfering; RPG; Reader; Reading; Reagent; Regulation; Reporting; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Role; SAPK1; Sampling; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spottings; Stress Proteins; System; System, LOINC Axis 4; TIRF Microscopy; TXT; Teratocarcinoma; Testing; Text; Time; Tissues; Total Internal Reflection Fluorescent; Total Internal Reflection Fluorescent Microscopy; Transcription; Transcription, Genetic; Transphosphorylases; Uncertainty; Validation; Viewpoint; Viewpoint (PT); Work; Xenopus; Zebra Danio; Zebra Fish; Zebrafish; adipogenesis; affinity purification; base; biological signal transduction; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; cardiogenesis; cell type; cellular polarity; doubt; embryo cell culture; embryonic cell culture; embryonic stem cell; experience; experiment; experimental research; experimental study; fly; fruit fly; gene product; genetic mapping; genome mutation; glycogen synthase a kinase; guanosine 3'5' monophosphate; heart development; heavy metal Pb; heavy metal lead; hormonal regulation; hormone regulation; human disease; hydroxyalkyl protein kinase; imaging; improved; in vivo; insight; interest; knock-down; lipid biosynthesis; lipogenesis; malignancy; membrane structure; model development; mutant; neoplasm/cancer; novel; pathway; phosphorylase b kinase kinase; plasmalemma; protein protein interaction; receptor binding; reconstitute; reconstitution; research study; response; rho; scaffold; scaffolding; siRNA; skills; social role; stem cell of embryonic origin; subcellular fractionation; success; trafficking",REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMS,,30111,DEV2,Development - 2 Study Section,,28,382348,
7770848,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK032948-27,,NIDDK:501580;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,FARMINGTON,UNITED STATES,NEUROSCIENCES,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"MAINS, RICHARD E;",1881292;,5R01DK032948,09/01/1990,01/31/2014,"2-dimensional; ACTH; ACTH (1-39); ACTH-beta-Lipotropin Precursor; ARHGEF1; ARHGEF1 gene; Actins; Address; Adrenocorticotropic Hormone; Adrenocorticotropin; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Anabolism; Antidiuretic Hormone; Antidiuretic Hormones; Assay; Binding; Binding (Molecular Function); Bioassay; Biogenesis; Biologic Assays; Biological Assay; CRH; CRH gene; Cell Communication and Signaling; Cell Culture Techniques; Cell Function; Cell Membrane Lipids; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Cellular biology; Chemotherapy-Hormones/Steroids; Complex; Cornu Ammonis; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Corticotropin; Corticotropin (1-39); Corticotropin-beta-Lipotropin Precursor; Cytoplasmic Granules; Cytoskeletal System; Cytoskeleton; DH Domain; Data; Dbl Homology Domain; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; EC 2.7; Endocrine; Endocrine Gland Secretion; Endorphin-ACTH Precursor; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Essential Genes; Exons; Face; Family; Fluorescence; G Protein-Coupled Receptor Signaling; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GEF1; GHN; GPCR Signaling; GTP; GTP GDP exchange factor; Gene Expression; Generalized Growth; Genes; Genes, Essential; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Genetically Engineered Mouse; Growth; Growth Hormone; Growth Hormone 1; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Health; Hippocampus; Hippocampus (Brain); Hormones; Human; Human, General; Hydroxylases; Hypophysis; Hypophysis Cerebri; In Vitro; Individual; Injection of therapeutic agent; Injections; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Isoforms; Kinases; Knock-out; Knockout; Knockout Mice; Knowledge; LBCL2; Lentivirinae; Lentivirus; Link; Linkage Analysis; Lipids; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Lipids; Membrane Proteins; Membrane-Associated Proteins; Mice; Mice, Knock-out; Mice, Knockout; Mixed Function Oxidases; Mixed Function Oxygenases; Molecular Interaction; Monooxygenases; Murine; Mus; Mutation; Nerve Impulse Transmission; Nerve Transmission; Nervous System, Pituitary; Neuronal Transmission; Neurophysiology - biologic function; Nuclear; Nucleus; Null Mouse; Origin of Life; P115-RHOGEF; POMC; Partner in relationship; Pathway interactions; Patients; Peptides; Phosphotransferases; Physiologic; Physiological; Pituitary; Pituitary Gland; Pituitary Growth Hormone; Pituitary Hormones; Play; Primary Senile Degenerative Dementia; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Pro-Opiomelanocortin; Process of secretion; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proopiocortin; Proopiomelanocortin; Protein Isoforms; Proteins; Proteomics; RNA Splicing; Recycling; Regulation; RhoGEF Domain; Role; SH3 Domains; SRC Homology Region 3 Domain; STH; SUB1.5; Schizophrenia; Schizophrenic Disorders; Secretory Granules; Secretory Vesicles; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somatotropin; Spectrin; Splicing; Structure; Subcellular Process; Subfamily lentivirinae; Surface Proteins; Swelling; Testing; Therapeutic Hormone; Tissue Growth; Transmembrane Protein; Transphosphorylases; Tumor Cell; V-ATPase; V-type ATPase; VESCL; Variant; Variation; Vasopressins; Vesicle; Virus-Lenti; alpha-amidating enzyme AE-II; beta-Hypophamine; biological signal transduction; biosynthesis; cell biology; cell type; dementia of the Alzheimer type; dementia praecox; early onset; exchange factor; facial; family based linkage study; gel electrophoresis; gene product; genetic analysis; genetic linkage analyses; genetic linkage analysis; genome mutation; granule; hGHN; hippocampal; improved; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; intracellular skeleton; linkage analyses; mate; membrane structure; mutant; neoplastic cell; neural function; neurotransmission; ontogeny; pathway; peptide hormone; peptidyl alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-amidating monooxygenase; peptidylglycine alpha-hydroxylating monooxygenase; peptidylglycine hydroxylase; peptidylglycine monooxygenase; primary degenerative dementia; protein complex; protein protein interaction; public health relevance; recombinase; restraint stress; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; schizophrenic; secretion process; senile dementia of the Alzheimer type; social role; somatotropic hormone; tool; trafficking; tumor; two-dimensional; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",Cell Biology of Bioactive Peptide Secretion," Precise control of the biosynthesis, storage and secretion of bioactive peptides requires the coordinate control of many different cellular processes. Genetically engineered mice were used to determine that Kalirin, a large protein with domains that allow it to interact with immature secretory granules, regulate the actin cytoskeleton, bind to lipid membranes and respond to multiple protein/protein interactions, plays an essential role in peptide hormone release. Mutations in the Kalirin gene or changes in Kalirin expression have been correlated with early- onset coronary artery disease, schizophrenia and Alzheimer Disease, making a better understanding of the functions of this complex protein relevant to human health.",32948,MCE,Molecular and Cellular Endocrinology Study Section,,27,501580,
7758711,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK033765-27,,NIDDK:557729;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,BIOLOGY,08,049435266,US,MA,02215,BOSTON UNIVERSITY,"WAXMAN, DAVID J;",1873055;,5R01DK033765,04/01/1999,01/31/2013,"21+ years old; Acids, Bile; Adult; Animal Welfare; Bibliography; Bile Acids; Biological Models; Blood Plasma; Cancer Causing Agents; Carcinogens; Complex; Country; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Dependence; Drugs; Ecological impact; Endocrine; Environment; Environmental Impact; Enzymes; Equipment; Ethics Committees, Research; GHN; Gene Expression; Genes; Goals; Growth Hormone; Growth Hormone 1; Hepatic; Hormones, Polypeptide; Human, Adult; Hypophysis; Hypophysis Cerebri; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Liver; METBL; Mammals, Mice; Medical; Medication; Metabolic Processes; Metabolism; Mice; Model System; Models, Biologic; Molecular; Murine; Mus; Names; Nervous System, Pituitary; Oncogens; P450; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic pulse; Pituitary; Pituitary Gland; Pituitary Growth Hormone; Plasma; Polypeptide Hormones; Principal Investigator; Programs (PT); Programs [Publication Type]; Pulse; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Serum, Plasma; STAT protein; STH; Serum, Plasma; Signal Transducer and Activator of Transcription; Somatotropin; Testing; Therapeutic Steroid Hormone; Vertebrate Animals; Vertebrates; abstracting; adult human (21+); body system, hepatic; drug/agent; expiration; genome-wide; hGHN; human subject; male; organ system, hepatic; programs; sex; somatotropic hormone; steroid hormone; transcription factor; vertebrata",Cytochrome P450-Endogenous Substrate Metabolism,,33765,MCE,Molecular and Cellular Endocrinology Study Section,,27,557729,
7751790,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK034108-24,,NIDDK:516616;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,PEDIATRICS,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"FARRELL, PHILIP M;",1864752;,5R01DK034108,08/01/1985,12/31/2011,"0-11 years old; 0-6 weeks old; 12-20 years old; 14 year old; Acceleration; Accounting; Active Follow-up; Acute; Address; Adolescence; Adolescent; Adolescent Youth; Advisory Committees; Age; Analysis, Data; Benefits and Risks; Biochemical; CDC; CF lung disease; CF patients; Cardiac Diseases; Cardiac Disorders; Care, Health; Caring; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Chest; Child; Child Youth; Childhood; Children (0-21); Children with CF; Chronic; Chronic Disease; Chronic Illness; Chronic lung disease; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Control Groups; Costs and Benefits; Cystic Fibrosis; Cystic Fibrosis, Pulmonary; DNA Alteration; DNA analysis; DNA mutation; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deterioration; Diagnosis; Diet Supplement; Dietary Supplements; Disease; Disease Progression; Disorder; Disturbance in cognition; Drugs; Early Diagnosis; Early treatment; Economics; Effects, Longterm; Enrollment; Epidemic Acute Poliomyelitis; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Equation; Evaluation; Evolution; Expert Opinion; Follow-Up Studies; Followup Studies; Forecast of outcome; Foundations; Funding; Gender; Gene Alteration; Gene Mutation; Generalized Growth; Genetic; Genetic Condition; Genetic Diseases; Genetic Screening; Genetic mutation; Genotype; Goals; Growth; HOSP; Health Policy; Health Services; Healthcare; Heart Diseases; Hereditary Disease; Hospitalization; Human, Child; Impaired cognition; Infant, Newborn; Infection; Investigation; Knowledge; Learning; Life; Living Costs; Long-Term Effects; Lung; Lung diseases; Malnutrition; Marshal; Measures; Medication; Method LOINC Axis 6; Methodology; Methods; Modeling; Molecular Disease; Molecular Genetic; Molecular Genetics; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucoviscidosis; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neonatal Screening; Newborn Infant; Newborn Infant Screening; Newborns; Nutritional; Nutritional Deficiency; Nutritional Supplement; Nutritional status; Opinion, Expert; Outcome; P. aeruginosa; P.aeruginosa; Patients; Pediatric Research; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phenotype; Polio; Poliomyelitis; Poliomyelitis, Acute; Population; Prevention; Prognosis; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Puberty; Pulmonary Cystic Fibrosis; Pulmonary Diseases; Pulmonary Disorder; QOL; Quality of life; Randomized; Randomized Clinical Trials; Recommendation; Registries; Respiratory Disease; Respiratory Disorder; Respiratory Infections; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory Tract Infections; Risk; Risk Factors; Role; SUBGP; Screening procedure; Secondary to; Sequence Alteration; Study of epidemiology; Subgroup; Task Forces; Testing; Thorace; Thoracic; Thorax; Time; Tissue Growth; Treatment Cost; Trials, Randomized Clinical; Trypsinogen; Undernutrition; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Vaccines; Wisconsin; adolescence (12-20); children; children with cystic fibrosis; chronic disease/disorder; chronic disorder; clinical data repository; clinical data warehouse; clinical significance; clinically significant; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cohort; cost; cost effectiveness; cystic fibrosis lung disease; cystic fibrosis patients; data repository; design; designing; diagnosis standard; dietary deficiency; disease/disorder; drug/agent; early detection; economic outcome; enroll; epidemiology study; experience; experiment; experimental research; experimental study; follow-up; fourteen year old; genetic disorder; health care policy; health care service; heart disorder; hereditary disorder; human puberty; improved; infancy; infantile; innovate; innovation; innovative; interest; juvenile; juvenile human; lung disorder; meetings; mucoid; multidisciplinary; newborn human (0-6 weeks); newborn screening; ontogeny; outcome forecast; patient population; patients with CF; patients with cystic fibrosis; pediatric; prospective; psychosocial; pulmonary; randomisation; randomization; randomly assigned; relational database; research study; screening; screenings; social role; teenage; youngster",Pulmonary Benefits of Cystic Fibrosis Neonatal Screening,,34108,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,24,516616,
7752803,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK038389-23,,NIDDK:324095;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW BRUNSWICK,UNITED STATES,NUTRITION,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"STORCH, JUDITH ;",8381675;,5R01DK038389,05/01/1987,01/31/2014,"2-acylglycerol O-acyltransferase; Address; Adipocyte Membrane Protein p88; Amino Acids; Animals; Apical; Area; Assimilation; Assimilations; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biogenesis; Biological Models; Blood Serum; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor); CD36 Antigens; CD36 Fatty Acid Transporter; CSVTCG-Specific Receptor; CSVTCG-Specific TSP-1 Receptor; Caco-2 Cells; Cell Culture Techniques; Cell membrane; Cell model; Cell surface; Cells; Cellular model; Chylomicrons; Columnar Epithelium; Complement; Complement Proteins; Congenic Strain; Cultured Cells; Cytoplasmic Membrane; DNA; Deoxyribonucleic Acid; Development; Diabetes Mellitus; Diet; Dietary Fats; Digestion; Employee Strikes; Enterocytes; Enzymes; Epithelial Cells; Exhibits; FAT (Fatty Acid Translocase) - CD36 Antigen; Fatty Acid Binding Protein 1, Liver; Fatty Acid Metabolism Pathway; Fatty Acid-Binding Protein 1; Fatty Acid-Binding Protein, Liver; Fatty Acids; GPIIIb Platelet Glycoprotein; GPIV Platelet Glycoprotein; Gastrointestinal Tract, Small Intestine; Genes; Goals; Hyperglyceridemia; Hypertriglyceridemia; In Vitro; Individual; Intermediary Metabolism; Intestinal; Intestines; Intestines, Small; Kinetic; Kinetics; Knock-out; Knockout; Knockout Mice; Laboratories; Lipid Trafficking; Lipids; Lipoproteins; METBL; MGAT enzyme; Mammals, Mice; Membrane; Membrane Transport Proteins; Membrane Transporters; Metabolic; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Knock-out; Mice, Knockout; Model System; Modeling; Models, Biologic; Molecular; Monoacylglycerols; Monoglycerides; Murine; Mus; Null Mouse; OKM5 Antigen; Origin of Life; Pathway interactions; Phenotype; Phosphatides; Phospholipids; Plasma Membrane; Platelet Glycoprotein IIIb; Platelet Glycoprotein IV; Platelet Membrane Glycoprotein IIIb; Platelet Membrane Glycoprotein IV; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Proteomics; Raised TG; Raised triglycerides; Regulation; Research; Role; Serum; Small Intestines; Strikes; Strikes, Employee; Structural Protein; Structure; Structure-Activity Relationship; Surface; System; System, LOINC Axis 4; Thrombospondin Receptors; Time; Transfection; Transgenic Organisms; Triacylglycerol; Triglyceride increased; Triglycerides; Triglycerides high; Work; Z protein, fatty acid binding; acylglycerol palmitoyltransferase; aminoacid; atheromatosis; atherosclerotic vascular disease; base; bowel; chemical structure function; diabetes; dietary lipid; elevated tg; elevated triglyceride; fat metabolism; fatty acid metabolism; fatty acid transport; fatty acid-binding proteins; gene product; inhibitor; inhibitor/antagonist; interest; intestinal fatty acid binding protein; lipid metabolism; lipid transport; membrane model; membrane structure; monoacylglycerol acyltransferase; monoacylglycerol-acyl-coenzyme A acyltransferase; monoglyceride acyltransferase; mouse model; mutant; oxidation; pathway; plasmalemma; programs; protein function; public health relevance; response; small bowel; social role; structure function relationship; trafficking; transgenic; uptake",Lipid transport in the intestine," Lipid Transport in the Intestine Westerns diets often contain large quantities of dietary lipid, all of which must be digested, absorbed, and transported by the small intestine. Elevated serum lipid levels following meals are thought to be important in the development of atherosclerosis and diabetes. In the proposed research, we will investigate two incompletely understood areas of intestinal lipid assimilation. We will elucidate the specific functions of two intracellular fatty acid binding proteins in fatty acid transport, and we will determine how the products of lipid digestion, fatty acids and monoacylglycerols, are trafficked within the intestinal cell, leading to alterations in lipid metabolism. These studies will enable us to understand how to regulate the rate and extent of dietary lipid assimilation.",38389,INMP,Integrative Nutrition and Metabolic Processes Study Section,,23,324095,
7766259,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK040936-22,,NIDDK:329165;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SHULMAN, GERALD I;",1867670;,5R01DK040936,12/01/1988,01/31/2012,"1,2-diacylglycerol; ATP-protein phosphotransferase; Address; Age; Aged 65 and Over; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Antisense Technology; Arts; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; CoA; Coenzyme A; Common Rat Strains; D-Glucose; DAG; DNA Alteration; DNA Damage; DNA Injury; DNA Polymerases; DNA mutation; DNA, Mitochondrial; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Defect; Dehydrogenases; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diacylglycerols; Diglycerides; EC 2; EC 2.7.7.7; Elderly; Elderly, over 65; Energy Expenditure; Energy Metabolism; Fats; Fatty Acid Metabolism Pathway; Fatty Liver; Fatty acid glycerol esters; Gene Alteration; Gene Expression Inhibitor; Gene Mutation; Genetic mutation; Glucose; Grant; Hepatic; Hereditary; Human; Human, General; Humulin R; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Individual; Inherited; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intracellular Accumulation of Lipids; Investigators; Knockout Mice; Lead; Length of Life; Lipids; Liquid Chromatography; Liver; Liver Steatosis; Longevity; MODY; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Mitochondrial DNA; Murine; Mus; Muscle; Muscle Tissue; NIDDM; NMR Spectroscopy; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Oligonucleotides, Antisense; Organ; Oxidative Stress; Oxidoreductase; PPAR; Parents; Pathogenesis; Pb element; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Prevention; Programs (PT); Programs [Publication Type]; Protein Kinase; Radioactive; Rat; Rat Protein; Rattus; Reductases; Research Personnel; Researchers; Rodent Model; Role; Sequence Alteration; Spectroscopy; Spectroscopy, NMR; Spectrum Analyses; Spectrum Analysis; Subcellular Process; T2D; T2DM; Techniques; Testing; Transferase; Transgenic Mice; Transgenic Organisms; Type 2 diabetes; Type II diabetes; adipogenesis; adult onset diabetes; advanced age; awake; body system, hepatic; catalase; diacylglycerol; diglyceride; elders; fatty acid metabolism; feeding; geriatric; glucose RA; glucose metabolism; glucose production; glucose rate of appearance; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hepatic steatosis; hydroxyalkyl protein kinase; in vivo; insight; insulin resistant; insulin signaling; ketosis resistant diabetes; late life; later life; life span; lifespan; lipid biosynthesis; lipogenesis; maturity onset diabetes; mitochondrial; mitochondrial dysfunction; mouse model; mtDNA; novel; nuclear magnetic resonance spectroscopy; offspring; older adult; older person; organ system, hepatic; overexpression; oxidation; phosphorylase b kinase kinase; prevent; preventing; programs; senior citizen; social role; tandem mass spectrometry; transgenic",Mechanisms of Fat Induced Insulin Resistance,,40936,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,22,329165,
7751315,R01,DK,5,,01/01/2010,12/31/2010,PA-96-055,5R01DK041707-17,,NIDDK:304303;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"SANDS, JEFF M;",1887615;,5R01DK041707,08/01/1989,12/31/2011,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 3'5'-cyclic ester of AMP; A1 protein; Acute; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Antidiuretic Hormone; Antidiuretic Hormones; Apical; Biological; Brattleboro Rats; Canine Species; Canis familiaris; Carbamide; Carrier Proteins; Cell Line; Cell Lines, Strains; Cell membrane; CellLine; Cells; Centrifugation; Cloning; Coleonol; Common Rat Strains; Complementary DNA; Cristobalite; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Membrane; DNA, Complementary; Data; Dogs; Duct; Duct (organ) structure; Elaqua XX; Electron Microscopy; Forskolin; Fractionation, Centrifugation; Funding; Genes; Goals; Half-Life; Half-Lifes; Hydrogen Oxide; Investigators; Isoforms; Kidney; MDCK cell; Macropain; Macroxyproteinase; Madin Darby canine kidney cell; Mammals, Dogs; Mammals, Rats; Measures; Mediating; Membrane; Multicatalytic Proteinase; Nephrons; PKA; Pathway interactions; Permeability; Phosphorylation; Physiologic; Physiological; Plasma Membrane; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Protein Isoforms; Protein Kinase A; Protein Kinase A Inhibitor; Protein Phosphorylation; Proteins; Proteosome; RF-C protein; Rat; Rats, Brattleboro; Rattus; Receptor Protein; Regulation; Research Personnel; Researchers; Retrieval; Sand; Signal Pathway; Silica; Silicon Dioxide; Suspension substance; Suspensions; System; System, LOINC Axis 4; Testing; Transport Proteins; Transporter Protein; Tridymite; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Urea; Urea Carbamide; Ureaphil; Urinary System, Kidney; Urinary System, Urine; Urine; Uriniferous Tube; V2 Receptors; Vasopressin Receptor; Vasopressins; Water; Work; activator 1 protein; adenosine 3'5' monophosphate; analog; beta-Hypophamine; cAMP; cAMP-Dependent Protein Kinases; cDNA; canine; collecting duct urea transporter; cultured cell line; domestic dog; gene product; insight; membrane structure; multicatalytic endopeptidase complex; novel; pathway; plasmalemma; polyclonal antibody; receptor; renal; replication factor C; suspension; ubiquination; ubiquitin conjugation; urea transporter",Regulation of Rat Renal Inner Medullary Function,,41707,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,17,304303,
7744609,R01,DK,5,,12/01/2009,11/30/2010,PA-05-049,5R01DK042921-18,,NIDDK:303202;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"IGARASHI, PETER ;",1902662;,5R01DK042921,04/15/1991,11/30/2010,"0-11 years old; APF-1; ARPKD; ATP-Dependent Proteolysis Factor 1; Animal Model; Animal Models and Related Studies; Assay; Autosomal Recessive Polycystic Kidney; Autosomal Recessive Polycystic Kidney Disease; Bile Ducts; Bile duct structure; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; C-terminal; Cell Differentiation; Cell Differentiation process; Child; Child Youth; Children (0-21); Chromatin Structure; Combining Site; Cyst; Cystic Kidney Diseases; Cystic Renal Diseases; Cystic kidney; DNA Binding; DNA Binding Interaction; DNA Recombination; DNA recombination (naturally occurring); Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Differential Gene Expression; Down-Regulation; Down-Regulation (Physiology); Downregulation; Duct; Duct (organ) structure; Epithelial; Exhibits; Family; Gastrointestinal Tract, Pancreas; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genes, LacZ; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic Transcription; Genetic defect; Genitourinary; Genitourinary system; Goals; HMG-20; High Mobility Protein 20; Histone Acetylase; Histone Acetylation; Histones; Homeo Domain; Human; Human, Child; Human, General; Infant; Investigators; Kidney; Kidney Cyst; Kidney Failure; Kidney Insufficiency; Knock-in; Knock-in Mouse; L-Lysine; LacZ; LacZ Genes; Ligase; Link; Liver; Location; Lysine; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Mice; Mice, Mutant Strains; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Modification; Molecular; Murine; Mus; Mutant Strains Mice; Mutate; Mutation; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Organ; Organogenesis; PKHD1 gene; Pancreas; Pancreatic; Pathogenesis; Pattern; Phenotype; Polycystic Kidney; Polycystic Kidney, Autosomal Recessive; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; Reactive Site; Recessive Polycystic Kidney Disease; Recombination; Recombination, Genetic; Regulation; Regulatory Element; RegulatoryElement; Renal Cell; Renal Cyst; Renal Failure; Renal Insufficiency; Reporter Genes; Research Personnel; Researchers; Role; Site; Synthetases; T2D; T2DM; Targetings, Gene; Testing; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transcriptional Activation Domain; Transgenic Mice; Transgenic Organisms; Two Hybrid; Type 2 diabetes; Type II diabetes; Ubiquitilation; Ubiquitin; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Ubiquitination; Ubiquitinoylation; Up-Regulation; Urinary System, Kidney; Urogenital; Urogenital System; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adult onset diabetes; bile duct; bile ductule; body system, hepatic; children; deletion analysis; disease phenotype; gene product; genome mutation; hepatocyte nuclear factor; histone acetyltransferase; homeodomain; in vivo; inhibitor; inhibitor/antagonist; insight; ketosis resistant diabetes; kidney cell; kidney development; maturity onset diabetes; microarray technology; model organism; mouse mutant; mutant; nephrogenesis; novel; organ system, hepatic; polycystic kidney and hepatic disease 1 (autosomal recessive); programs; renal; social role; transcription factor; transgenic; ubiquination; ubiquitin conjugation; ubiquitin ligase; urogenital system (urinary part); yeast two hybrid system; youngster",Regulation of kidney-Specific Gene Expression,,42921,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,18,303202,
7752546,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK043405-18,,NIDDK:364716;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"GOLDENRING, JAMES RICHARD;",1865905;,5R01DK043405,04/01/1991,12/31/2012,"3'5'-cyclic ester of AMP; A kinase anchoring protein; AKAP; AKAP350; AKAP450; AKAP9; AKAP9 gene; ATP-protein phosphotransferase; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Attention; CDC42 Homolog Gene; CDC42-Interacting Protein Gene; CG-NAP; CIP4; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Casein Kinase 1; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Centrosome; Code; Coding System; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Granules; Cytoplasmic Membrane; Cytosol; Epithelial Cells; G25K Gene; GP Gene; Gene Products, RNA; Genes; Golgi; Golgi Apparatus; Golgi Complex; Hyperion; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigation; KIAA0803; Location; Macromolecular Protein Complexes; Mediation; Membrane; Messenger RNA; Micro-tubule; Microtubules; Movement; Multiprotein Complexes; Negotiating; Negotiation; Organelles; PDE; PDE4D3; PKA; PKC; Phosphatases; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphodiesterases; Phosphohydrolases; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Plasma Membrane; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Production; Protein Kinase; Protein Kinase A; Protein Kinase C; Protein Kinase CK1; Protein Kinase CKI; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Proteins; Quelling; RNA; RNA Interference; RNA Silencing; RNA Silencings; RNA Splicing; RNA, Messenger; RNA, Non-Polyadenylated; RNA, Small Interfering; RNAi; Regulation; Ribonucleic Acid; Role; Scaffolding Protein; Second Messenger Systems; Second Messengers; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Specificity; Splicing; Stress; Structure; Subcellular Process; Surface; System; System, LOINC Axis 4; TRIP10; TRIP10 gene; Thyroid Hormone Receptor Interactor 10 Gene; Transcript; Translations; Variant; Variation; Yotiao; adenosine 3'5' monophosphate; biological signal transduction; body movement; cAMP; cAMP-Dependent Protein Kinases; casein kinase I; gene product; glycogen synthase a kinase; granule; hydroxyalkyl protein kinase; mRNA; membrane structure; novel; phosphodiesterase 4D; phosphodiesterase 4D3; phosphoric diester hydrolase; phosphorylase b kinase kinase; plasmalemma; public health relevance; response; scaffold; scaffolding; second messenger; siRNA; social role; trafficking",Cyclic AMP Mediation of Epithelial Cell Function, NARRATIVE AKAP350 is a large protein that can potentially assemble large regulatory compress within the cell. These complexes appear to coordinate the movement intracellular proteins and messenger RNAs responsible for far ranging processes within cells. These processes can have diverse influences on the proper functioning of cells including the production and targeting of proteins to membrane surfaces and the response of cells to various induced stresses in normal and pathological conditions.,43405,ZRG1,Special Emphasis Panel,,18,364716,
7753154,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK044234-17,,NIDDK:362370;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CZAJA, MARK J.;",1899990;,5R01DK044234,04/01/1992,12/31/2011,"2-Methyl-1,4-naphthalenedione; 2-Methyl-1,4-naphthoquinone; 2-Methylnaphthoquinone; 4,4'-Bipyridinium, 1,1'-dimethyl-; Ablation; Active Oxygen; Acute; Apoptosis; Apoptosis Pathway; Apoptotic; Biochemical; CAP4 protease; CASP8 Protein; Cachectin; Cachectin-Tumor Necrosis Factor; Caspase-8/Flice; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cells; Cellular injury; Cessation of life; D-Galactose, 2-amino-2-deoxy-; Data; Death; Development; E3 Ligase; E3 Ubiquitin Ligase; Equilibrium; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Family member; Funding; Galactosamine; Gene Expression; Gene Proteins; Goals; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Failure; Hepatic Parenchymal Cell; Hepatocyte; In Vitro; Injury; Injury to Liver; Intracellular Communication and Signaling; Investigation; Isoforms; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK-55; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; LPS; Lead; Lipopolysaccharides; Liver; Liver Cells; Liver Failure; Liver diseases; MACH protein; MAP Kinase 8; MAP Kinase 8 Gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MAPK9; MAPK9 gene; Mammals, Mice; Mch5 protease; Mediating; Menadione; Methyl Viologen; Mice; Mitochondria; Mitogen-Activated Protein Kinase 8; Molecular; Murine; Mus; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; PRKM8; PRKM9; Paraquat; Pathway interactions; Pb element; Phosphorylation; Prevention; Pro-Oxidants; Process; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Gene Products; Protein Isoforms; Protein Phosphorylation; Protein Turnover; Proteins; Public Health; RNA, Small Interfering; Reactive Oxygen Species; Regulation; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Toxin; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Ubiquitin-Protein Ligase E3; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vitamin K 3; Vitamin K3; balance; balance function; base; biological signal transduction; body system, hepatic; c jun; c-jun Amino-Terminal Kinase; c-jun Gene; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; caspase-8; cell damage; cell injury; electron acceptor; gene product; heavy metal Pb; heavy metal lead; hepatopathy; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; injury response; intervention development; jun-NH2-Terminal Kinase; liver disorder; mitochondrial; necrocytosis; organ system, hepatic; oxidant stress; p54aSAPK; pathway; prevent; preventing; protein degradation; protein expression; public health medicine (field); response; response to injury; siRNA; stress-activated protein kinase 1; therapy development; treatment development; tumor necrosis factor (unspecified); ubiquitin-protein ligase",Modulation of Acute Liver Injury,,44234,HBPP,Hepatobiliary Pathophysiology Study Section,,17,362370,
7751824,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK045713-16,,NIDDK:333828;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,RENO,UNITED STATES,PHYSIOLOGY,02,146515460,US,NV,89557,UNIVERSITY OF NEVADA RENO,"SMITH, TERENCE KEITH;",8143486;,5R01DK045713,02/28/1992,01/31/2013,"Affect; Afferent Neurons; Anal; Anus; Auerbach's Plexus; Automobile Driving; Bacteria; Blood Coagulation Factor IV; Body Tissues; Ca++ element; Calcium; Cations; Cavia; Cercopithecidae; Characteristics; Clinical; Coagulation Factor IV; Colon; Computers; Connector Neuron; Constipation; Crab-Eating Macaque; Data; Dendrites; Distal; Drivings, Automobile; Electrolytes; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enteral; Enteric; Factor IV; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gastrointestinal Tract, Small Intestine; Guinea Pigs; Human; Human, General; Hydrogen Oxide; ICC (Interstitial cell of Cajal); Image; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Interstitial Cell of Cajal; Interstitial cell of Cajal (ICC); Intestinal; Intestinal Motility; Intestines; Intestines, Small; Ion Channels, Potassium; K channel; Laboratories; Large Intestine; Leiomyocyte; Length; Macaca fascicularis; Mammals, Guinea Pigs; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Mediating; Methods and Techniques; Methods, Other; Modeling; Monkey, Crab-Eating; Monkey, Cynomolgus; Monkeys; Monkeys, Old World; Mononitrogen Monoxide; Motility, Intestinal; Motor; Motor Cell; Motor Neurons; Movement; Muscle, Involuntary; Muscle, Smooth; Myenteric Plexus; Myocytes, Smooth Muscle; Myxoid cyst; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Ganglion; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nutrient; Oral; Pathway interactions; Pattern; Peristalsis; Physiologic; Physiological; Potassium Channel; Primates; Production; Recovery; Rectum; Reflex; Reflex action; Sensory Cell Afferent Neuron; Sigmoid; Sigmoid colon; Small Intestines; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Stimulus; Stretching; Submucosa; System; System, LOINC Axis 4; Techniques; Tissues; Translations; Water; base; body movement; bowel; driving; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; imaging; large bowel; motoneuron; neural; neural mechanism; neuromechanism; neuronal; nodal myocyte; novel; pathway; postsynaptic; public health relevance; rectal; relating to nervous system; research study; response; small bowel",Relex Pathways Controlling Intestinal Motility, PROJECT NARRATIVE Slow transit constipation has been associated with colonic elongation and an excess production of nitric oxide. The factors underlying slow transit and accommodation of fecal material along the large bowel are unclear. In this proposal we show that when the isolated large bowel contains fecal material it is normally elongated and propulsion is slowed. Colonic elongation activates intrinsic sensory neurons that release nitric oxide to inhibit nerve circuits driving peristalsis. The elongation associated with an impacted colon is likely a contributing factor in slow transit constipation.,45713,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,16,333828,
7754049,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK045776-19,,NIDDK:248297;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,BIOCHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BANERJEE, RUMA V;",8274393;,5R01DK045776,02/01/1993,01/31/2011,"(R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase; 5'-deoxyadenosylcobalamin; Active Sites; Address; AdoCbl; Assimilation; Assimilations; Bacterial Gene Proteins; Bacterial Proteins; Binding; Binding (Molecular Function); C element; Carbon; Cell Line; Cell Lines, Strains; CellLine; Chaperone; Chemicals; Chemistry; Chimera Protein; Chimeric Proteins; Circular Dichroism Spectroscopy; Cobalamin; Coenzymes; Cofactors, Enzyme; Complex; Cyanocobalamin; Cyanocobalamin (Vitatmin B12); Cytoplasm; DNA Sequence Rearrangement; Data; Disease; Disorder; Electronics; Enzymes; Fibroblasts; Fusion Protein; G-Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPases; Gene Products, Bacterial; GeneHomolog; Genetic; Genetic Alteration; Genetic Change; Genetic Diseases, Inborn; Genetic defect; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Inborn Genetic Diseases; Individual; Inherited disorder; Intermediary Metabolism; Intramolecular Transferases; Kinetic; Kinetics; L-Methionine; Laboratories; METBL; Magnetism; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Maps; Metabolic Pathway; Metabolic Processes; Metabolism; Methionine; Methionine, L-Isomer; Methods; Methods and Techniques; Methods, Other; Methylmalonyl-CoA Isomerase; Methylmalonyl-CoA Mutase; Methylobacterium extorquens; Mitochondria; Mitochondrial Proteins; Modeling; Molecular Chaperones; Molecular Interaction; Mutase; Mutation; Nucleotides; Ortholog; Orthologous Gene; Pathway interactions; Patients; Physiologic pulse; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Pulse; Reaction; Rearrangement; Role; Science of Chemistry; Sites, Active; Skeleton; Solutions; Source; Spectroscopy; Spectroscopy, CD/ORD; Spectroscopy, Circular Dichroism; Spectrum Analyses; Spectrum Analysis; Structure; Supplementation; Surface; System; System, LOINC Axis 4; Techniques; Testing; Thermodynamic; Thermodynamics; VIT B12; Vitamin B 12; Vitamin B12; adenosylcobalamin; cobamamide; coenzyme A, S-(hydrogen butanedioate); coenzyme B12; coenzyme analog; cofactor; cross-link; crosslink; cultured cell line; desoxy-5'-adenosine-5' alpha-(dimethyl-5,6-benzimidazolyl)cobamide; desoxyadenosylcobalamine; dibencozide; disease/disorder; gene discovery; gene product; genome mutation; guanosinetriphosphatase; inborn error; insight; magnetic; methylmalonic acidemia; methylmalonic aciduria; methylmalonyl CoA; methylmalonyl-coenzyme A; mitochondrial; pathway; polypeptide; programs; protein complex; protein protein interaction; social role; succinyl-CoA; succinyl-coenzyme A; vitamin B12 coenzyme; vitamin B12 compound",A Radical Enzyme and its Escorts,,45776,MSFA,Macromolecular Structure and Function A Study Section,,19,248297,
7747998,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK047186-14,,NIDDK:345048;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HODIN, RICHARD A.;",3166139;,5R01DK047186,08/01/1994,12/31/2011,"Absorption; Acetylation; Activation, Gene; Affect; Alkaline Phosphatase; Antibodies; Antigens, Differentiation; Assay; Atrophic; Atrophy; Award; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood Serum; CHIP assay; Cell Culture System; Cell Culture Techniques; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Structure; Clinical; DISSEC; Dietary Fats; Differentiation Antigens; Differentiation Markers; Disease; Disorder; Dissection; Dysfunction; Enterocytes; Epithelial; Epithelial Cells; FLR; Failure (biologic function); Functional disorder; Funding; Gene Action Regulation; Gene Activation; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Gut Epithelium; Histone Code; Histones; Hyperplasia; Hyperplastic; INFLM; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Intestinal; Intestines; Investigators; LPS; Lead; Lipopolysaccharides; Marker Antigens; Markers, Differentation; Methylation; Microbe; Model System; Models, Biologic; Modification; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nucleic Acid Regulatory Sequences; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Pathologic; Pathway interactions; Patients; Pb element; Phenotype; Physiologic; Physiological; Physiology; Physiopathology; Play; Precipitation; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Protein Methylation; Proteins; RNA Expression; Regulator Regions, Nucleic Acid; Regulatory Protein; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research Design; Research Personnel; Research Proposals; Researchers; Resistance; Role; Salmonella; Sepsis; Serum; Starvation; Stress; Study Type; Subcellular Process; Targetings, Gene; Toxin; Transcription; Transcription Activation; Transcription Repression; Transcription, Genetic; Transcriptional Activation; Transcriptional Repression; Trauma; Up-Regulation; Work; absorption; alkaline phosphomonoesterase; base; bloodstream infection; bowel; chromatin immunoprecipitation; cytokine; deprivation; dietary lipid; disease/disorder; failure; gastrointestinal epithelium; gene product; gene repression; genetic regulatory element; genetic regulatory protein; glycerophosphatase; heavy metal Pb; heavy metal lead; in vitro Model; in vivo; in vivo Model; pathophysiology; pathway; programs; regulatory gene product; resistant; response; social role; study design; therapeutic target; transcription factor",Molecular Mechanisms of Intestinal Atrophy/Hyperplasia,,47186,ZRG1,Special Emphasis Panel,,14,345048,
7753579,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK047618-22,,NIDDK:743243;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CAMBRIDGE,UNITED STATES,,08,120989983,US,MA,021421479,WHITEHEAD INSTITUTE FOR BIOMEDICAL RES,"LODISH, HARVEY F;",1862156;,5R01DK047618,01/01/1989,12/31/2012,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 5'-AMP-activated protein kinase; ACRP30 protein; AMP-PK reactivator; AMP-activated kinase; AMP-activated protein kinase; AMP-activated protein kinase kinase; AMPK enzyme; AMPK kinase; Acid-Thiol Ligases; Acyl CoA; Acyl CoA Synthetases; Acyl Coenzyme A; Acyl Coenzyme A Synthetases; Adipocytes; Adipose Cell; Animal Welfare; Bibliography; Bifunctional Reagents; Binding; Binding (Molecular Function); Binding Proteins; Biological; Biotin; Body Tissues; Body fat; CDH13; CDH13 protein, human; Cadherin-13; Carrier Proteins; Cell Communication and Signaling; Cell Signaling; Cell Surface Proteins; Cell membrane; Cells; Chemotherapy-Hormones/Steroids; Co A Ligases; CoA; Coenzyme A; Coenzyme A Ligases; Coenzyme A Synthetases; Coenzyme A, S-(hydrogen propanedioate); Complex; Country; Coupled; Cross-Linking Reagents; Crosslinking Reagents; Cytoplasmic Membrane; D-Glucose; Data; Dextrose; Ecological impact; Endocrine Gland Secretion; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Family; Fat Cells; Fats; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Acyl CoA; Fatty acid glycerol esters; Genes; Glucose; H-Cadherin; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG CoA reductase kinase kinase; HMG coenzyme A reductase (NADPH) kinase; Heart Cadherin; Hormones; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Intracellular Communication and Signaling; Isoforms; Knockout Mice; Length; Ligand Binding Protein; Link; Lipids; Lipocytes; Liver; Long-Chain Acyl CoA; METBL; Malonyl CoA; Malonyl Coenzyme A; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Mediating; Membrane Proteins; Membrane-Associated Proteins; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mice, Obese; Molecular Interaction; Monitor; Murine; Mus; Muscle; Muscle Cells, Embryonic; Muscle Cells, Precursor; Muscle Fibers; Muscle Tissue; Myoblasts; Myotubes; Names; Null Mouse; Obese Mice; Obesity; P105; Pathway interactions; Phosphorylation; Photometry/Spectrum Analysis, Mass; Plasma Membrane; Plasma Proteins; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Phosphorylation; Proteins; Proteins, Cell Surface; Proteomics; Receptor Protein; Receptor Signaling; Regulation; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Rhabdomyocyte; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Striated Muscle Tissue; Striated Muscles; Surface Proteins; T cadherin; T-Cad; Testing; Therapeutic Hormone; Tissues; Transport Proteins; Transporter Protein; Truncated-Cadherin; Vertebrate Animals; Vertebrates; Vitamin H; Work; abstracting; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adiposity; apM-1 protein; apM1 (adipose-specific) protein; base; biological signal transduction; body system, hepatic; coenzyme R; corpulence; corpulency; corpulentia; diabetic; expiration; fatty acid metabolism; feeding; gene product; glucose metabolism; hepatic gluconeogenesis; human subject; hydroxymethylglutaryl-CoA-reductase kinase; knock-down; member; muscle form; muscle metabolism; mutant; obese; obese people; obese person; obese population; organ system, hepatic; overexpression; oxidation; paralog; paralogous gene; pathway; plasmalemma; prevent; preventing; programs; protein expression; receptor; receptor coupling; shRNA; short hairpin RNA; small hairpin RNA; social role; thiokinase; tissue culture; uptake; vertebrata",Adiponectin and CTRP9 signaling in muscle and liver,,47618,MCE,Molecular and Cellular Endocrinology Study Section,,22,743243,
7764645,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK047814-16,,NIDDK:292370;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"HOLDEN, HAZEL ;",1873059;,5R01DK047814,06/01/1994,01/31/2011,"3,6-dideoxy-D-arabino-hexose; 3,6-dideoxy-L-xylo-hexose; ATGN; Affect; Anabolism; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antigens; Biochemical; Biological; Biological Function; Biological Process; C element; Carbohydrates; Carbon; Cell Adhesion; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Chimera Protein; Chimeric Proteins; Clinical; D-Galactose; Defect; Deoxy Sugars; Disease; Disorder; E-Mycin; Enzyme Gene; Enzymes; Ery-Tab; Eryc; Eryderm; Erythrocin; Erythromycin; Erythromycin A; Fertility/Fertilization; Fertilization; Foundations; Funding; Fusion Protein; Galactopyranose; Galactopyranoside; Galactose; Galactosemia; Galactosemias; Gene Transcription; Genes; Genetic; Genetic Transcription; Goals; Gram-Negative Bacteria; Grant; Ilotycin; Immune response; Impairment; In element; Indium; Intermediary Metabolism; Investigation; Laboratories; Lead; Leloir Pathway of Galactose Metabolism; METBL; Macrolide Antibiotics; Metabolic; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Miscellaneous Antibiotic; Molecular; Mutagenesis, Site-Directed; Nature; O Antigen, Bacterial; O Antigens; O-Specific Polysaccharides; Organism; Organism-Level Process; Organismal Process; Pathogenicity; Pathway interactions; Pb element; Pediamycin; Physiologic Processes; Physiological Processes; Play; Proteins; RNA Expression; RP-Mycin; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Research; Robimycin; Roentgen Rays; Role; S cerevisiae; Saccharomyces cerevisiae; Severities; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Source; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Techniques; Transcription; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Regulation; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repressor; Transcriptional Repressor/Corepressor; X-Radiation; X-Rays; Xrays; Yeast, Baker's; Yeast, Brewer's; Yeasts; anti-microbial agent; anti-microbial drug; antimicrobial agent; antimicrobial drug; ascarylose; base; biosynthesis; colitose; deoxysugar; design; designing; desosamine; dideoxyhexose; disease/disorder; gene product; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; interest; living system; pathway; social role; sugar; tyvelose",X-ray Studies of Sugar-Modifying Enzymes,,47814,MSFB,Macromolecular Structure and Function B Study Section,,16,292370,
7766911,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK047936-14,,NIDDK:517608;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TEMPE,UNITED STATES,OTHER BASIC SCIENCES,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"MANDARINO, LAWRENCE J;",1864008;,5R01DK047936,09/30/1994,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; Antibodies; Antiheparin Factor; Biochemical; Biopsy; Blood Platelet Factor IV; Blood platelet factor 4; CTGF; Cell Culture Techniques; Cell-Extracellular Matrix; Cells; Chemokine (C-X-C motif) Ligand 4; Defect; Development; ECM; Event; Extracellular Matrix; Extracellular Matrix Proteins; Factor 4; Femoral Artery; Funding; Gene Expression; Genes; Goals; Heparin Neutralizing Protein; Human; Human, General; Humulin R; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; INFLM; Immunoglobulin Enhancer-Binding Protein; In Vitro; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Instrumentation, Other; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Investigators; L-Serine; L-Threonine; Lipids; Liposyn; MMPs; Macropain; Macroxyproteinase; Man (Taxonomy); Man, Modern; Maps; Mass Spectrum; Mass Spectrum Analysis; Matrix Metalloproteinases; Mediator; Mediator of Activation; Mediator of activation protein; Mitochondrial Proteins; Molecular; Multicatalytic Proteinase; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NF-kB; NF-kappa B; NF-kappaB; NFKB; Novolin R; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Pathway interactions; Phosphopeptides; Phosphorylation; Phosphorylation Site; Photometry/Spectrum Analysis, Mass; Platelet Factor 4; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Phosphorylation; Proteosome; Recombinant Platelet Factor 4; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Role; Serine; Serine/Threonine Phosphorylation; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure of femoral artery; Testing; Threonine; Threonine Phosphorylation Site; Time; Transcription Factor NF-kB; artery infusion; connective tissue growth factor; cytokine; design; designing; experiment; experimental research; experimental study; femoral artery; fisp12 protein; gamma-Thromboglobulin; glucose metabolism; in vivo; instrumentation; insulin resistant; insulin signaling; insulin-like growth factor binding protein 8; kappa B Enhancer Binding Protein; man; man's; multicatalytic endopeptidase complex; novel; nuclear factor kappa beta; pathway; platelet factor IV; programs; research study; response; social role; volunteer",Molecular Regulation of Muscle Glucose Metabolism in Man,,47936,ZRG1,Special Emphasis Panel,,14,517608,
7781324,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK048215-13,,NIDDK:313253;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,ANATOMY/CELL BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"HOWARD, PAMELA S;",1883426;,5R01DK048215,09/30/1993,01/31/2012,"3-hydroxy-3-methylglutaryl coenzyme A Inhibitors; ANG-(1-8)Octapeptide; Adverse effects; Anatomic; Anatomical Sciences; Anatomy; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Animal Model; Animal Models and Related Studies; Antibodies; Attenuated; Autocrine Communication; Autocrine Signaling; Bladder; Bladder Obstruction; Bladder neck obstruction; Bone-Derived Transforming Growth Factor; CTGF; Cell Wall; Cell-Extracellular Matrix; Cells; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chronic; Collagen; Collagen Gene; Collagen Type I; Data; Development; Drugs; ECM; Extracellular Matrix; Extracellular Matrix Protein Gene; Extracellular Matrix Proteins; FDA approved; Fibroblasts; Fibrosis; Funding; Gene Products, RNA; Gene Proteins; Gene Targeting; General Population; General Public; Genes; Goals; Growth Factor Gene; HMG-CoA Reductase Inhibitors; Human; Human, General; Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; In Vitro; Inflammatory; Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase; Inhibitors, Hydroxymethylglutaryl-CoA; Inhibitors, Hydroxymethylglutaryl-Coenzyme A; Lamina Propria; Leiomyocyte; Lesion; Location; MMPs; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Meningomyelocele; Meningomyelocoele; Mice; Milk Growth Factor; Molecular; Molecular Analysis; Murine; Mus; Myelomeningocele; Myocytes, Smooth Muscle; Neurologic; Neurological; Obstruction; Obstructive Uropathy; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Platelet Transforming Growth Factor; Play; Process; Protein Gene Products; Proteins; Proto-Oncogene, Growth Factor; RNA; RNA, Non-Polyadenylated; Regulation; Research; Ribonucleic Acid; Role; Science of Anatomy; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Statins, HMG-CoA; Stream; TGF B; TGF-Beta 1; TGF-Beta1; TGF-beta; TGFB1; TGFB1 protein, human; TGFbeta; Targetings, Gene; Testing; Tethered Cord Syndromes; Therapeutic; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor Beta 1; Transforming Growth Factor beta; Transgenic Animals; Treatment Side Effects; Type 1 Collagen; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urethra; Urinary System, Bladder; anatomy; cell behavior; connective tissue growth factor; drug/agent; experiment; experimental research; experimental study; fisp12 protein; gene product; human TGFB1 protein; in vivo; in vivo Model; insulin-like growth factor binding protein 8; interstitial; model organism; non-compliance; paracrine; pathway; prevent; preventing; protein expression; research study; response; side effect; social role; therapy adverse effect; transforming growth factor beta1; treatment adverse effect; urethral; urinary bladder; urinary tract obstruction",Molecular Analysis of Collagen in Non-compliant Bladders,,48215,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,13,313253,
7759181,R01,DK,5,,02/01/2010,01/31/2011,PA-07-010,5R01DK050446-14,,NIDDK:312246;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"LEVIN, MARC S;",1887523;,5R01DK050446,08/01/1995,01/31/2012,"9-cis-Retinoic Acid Receptor; APO2L; Abscission; Address; Animal Welfare; Apo-2L; Apoptosis; Apoptosis Pathway; Area; Bibliography; Cell Adhesion; Cell Death; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Adhesion; Cellular Proliferation; Country; Ecological impact; Enterocytes; Environment; Environmental Impact; Epithelial Cells; Equipment; Ethics Committees, Research; Excision; Extirpation; Gastrointestinal Tract, Small Intestine; Gene Expression; Goals; Heterodimerization; Hyperplasia; Hyperplastic; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intestinal; Intestines; Intestines, Small; Mammals, Rodents; Mediating; Modeling; Morbidity; Morbidity - disease rate; Names; Nuclear Receptors; Nutrient; Nutritional; PPAR; Pathway interactions; Patients; Peroxisome Proliferator-Activated Receptors; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; QOL; Quality of life; RXR; RXR Protein; Regimen; Removal; Research; Research Ethics Committees; Research Resources; Resources; Retinoic Acid Agent; Retinoic Acid Receptor; Retinoic Acid Receptor RXR; Retinoic Acid and Derivatives; Retinoid X Receptors; Retinoids; Rodent; Rodentia; Rodentias; Role; Short Bowel Syndrome; Small Intestines; Surface; Surgical Removal; TL2; TNFSF10; TNFSF10 gene; TRAIL; Transplantation; Vertebrate Animals; Vertebrates; Villus; Vitamin A; abstracting; base; bowel; crypt cell; design; designing; expiration; functional loss; human subject; migration; necrocytosis; pathway; programs; resection; response; retinol; short gut syndrome; small bowel; social role; therapeutic target; transplant; vertebrata",NUTRIENT MODULATION OF GENE EXPRESSION IN GUT ADAPTATION,,50446,INMP,Integrative Nutrition and Metabolic Processes Study Section,,14,312246,
7751813,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK050603-30,,NIDDK:348618;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PEDIATRICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"SCHWARTZ, GEORGE J;",1902628;,5R01DK050603,07/01/1990,12/31/2010,"Acidosis; Acidosis, Renal Tubular, Type I; Acids; Alkalosis; Antibodies; Antibodies, Blocking; Antimorphic mutation; Back; Bicarbonates; Binding; Binding (Molecular Function); Biochemical; Blocking Antibodies; Blood; CBP-30; CBP-35; CBP35; Calcineurin; Carbohydrate-Binding Protein 35; Cell Differentiation; Cell Differentiation process; Cell-Extracellular Matrix; Cells; Ciclosporin; Classic Distal Renal Tubular Acidosis; CsA; Cyclophilins; Cyclosporin A; Cyclosporin-Binding Proteins; Cyclosporine; Cyclosporine A; Dark Cell; Defect; Deposit; Deposition; Development; Disease; Disorder; Distal Renal Tubular Acidosis; Distal renal tubular acidosis Type 1; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Duct; Duct (organ) structure; ECM; Epsilon-Binding Protein; Extracellular Matrix; Extracellular Matrix, Integrins; Galactoside-Binding Lectin 1; Galaptin; Galectin 1; Galectin 3; Goals; HCO3; HL-29; Hydrogen Carbonates; IgE Binding Protein; IgEBP; Immunosuppressants; Immunosuppressive Agents; In Vitro; Incubated; Integrins; Intercalated Cell; Isoforms; Kidney; Kidney Tubules; Knock-out; Knockout; L-14 Lectin; L-29 Lectin; L-31; L-34; L-Proline; L1-Lac Lectin; L30 Lectin; LGALS1; LGALS3; Life; MMPs; Mac-2 Antigen; Macrophage-2 Antigen; Mammals, Mice; Mammals, Rabbits; Matrix Metalloproteinases; Mediating; Metabolic; Metabolic acidosis; Mice; Molecular Interaction; Murine; Mus; Names; Organ; Oryctolagus cuniculus; PP2B; PPIase; Pathway interactions; Peptidyl-Prolyl cis-trans-Isomerase; Peptidylproline cis-trans-isomerase; Peptidylprolyl Isomerase; Phenotype; Process; Proline; Proline Isomerase; Proline Rotamase; Prolyl Isomerase; Protein Isoforms; Protein Phosphatase-2B; Proteins; Pump; Rabbit, Domestic; Rabbits; Receptor Protein; Renal tubule structure; Reticuloendothelial System, Blood; Role; SRCR Domain; Sandimmun; SangCya; Scavenger Receptor Cysteine-Rich Domain; Simulate; Testing; Urinary System, Kidney; base; cis-trans-Isomerases; cyclophilin; cyclophilin C; cyp C; disease/disorder; extracellular; gene product; hensin; immunophilin; immunosuppressive; in vivo; inhibitor; inhibitor/antagonist; knock-down; neoral; novel; pathway; polymerization; prevent; preventing; receptor; renal; renal tubule; sandimmune; social role",Bicarbonate Transport by the Maturing Renal Tubule,,50603,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,30,348618,
7764803,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK051406-13,,NIDDK:319770;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"HULTGREN, SCOTT J;",1903078;,5R01DK051406,01/01/1997,01/31/2012,"Accounting; Acute; Acute Disease; Adhesins, Bacterial; Antibiotic Resistance; Antibodies; Apoptosis; Apoptosis Pathway; Area; Back; Bacteria; Bacterial Adhesins; Bacterial Infections; Bacteriuria; Binding; Binding (Molecular Function); Bladder; Bladder Diseases; Bladder Disorder; Bladder Tissue; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood granulocytic cell; Bone Marrow; Cell Communication and Signaling; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Characteristics; Clinical; Clinical Research; Clinical Study; Colony-forming units; Communities; Cytokine Network; Cytokine Network Pathway; Cytology; Defect; Defense Mechanisms; Dendritic Cells; Diagnosis; Disease; Disorder; Dorsum; E. faecalis; E.faecalis; ELISA; Enterococcus; Enterococcus faecalis; Enzyme-Linked Immunosorbent Assay; Epithelial; Epithelial Cells; Epithelium; Escherichia coli Infections; Extensive Disease; Face; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; Future; Generalized Disease; Generalized Growth; Genes; Genetic; Genital System, Female, Vagina; Genus staphylococcus; Gram-Negative Bacteria; Gram-Positive Bacteria; Granular Leukocytes; Granulocytic cell; Growth; HOSP; Health Care Costs; Health Costs; Healthcare Costs; Hematopoietic; Heterophil Granulocyte; Histology; Hospitals; Host Defense; Host Defense Mechanism; Host Factor; Host Factor Protein; Human; Human, General; IHC; INFLM; Imagery; Immune; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunohistochemistry; Immunohistochemistry Staining Method; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Inbred Mouse; Infection; Infection Control; Infections, E coli; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Integration Host Factors; Intracellular Communication and Signaling; Invaded; Kinetic; Kinetics; LPS; Lead; Lipopolysaccharides; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Methicillin Resistance; Mice; Mice, Mutant Strains; Microbial Biofilms; Microscopy; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Murine; Mus; Mutant Strains Mice; Natural Immunity; Natural regeneration; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organism; Outcome; Pathogenesis; Pb element; Pilum; Plant Embryos; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Production; Property; Property, LOINC Axis 2; Recruitment Activity; Recurrence; Recurrent; Regeneration; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Bone Marrow; Role; S. faecalis; S.faecalis; Seeds; Signal Transduction; Signal Transduction Systems; Signaling; Sortings, Fluorescence-Activated Cell; Staphylococcus; Sterility; Streptococcus Group D; Streptococcus enterococcus group; Streptococcus faecalis; Stress Response Signaling; Surface; Symptoms; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TLR protein; TLR4; TLR4 gene; TLR4 receptor; TOLL; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Toll-4 receptor; Toll-like receptors; Toxin; Tropism; UPEC; UTI; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Urethra; Urinary System, Bladder; Urinary System, Urine; Urinary tract; Urinary tract infection; Urinary tract infectious disease; Urination; Urine; Uropathogen; Uropathogenic E coli; Uropathogenic E. coli; Uropathogenic E.coli; Uropathogenic Escherichia coli; Vagina; Vaginal; Vancomycin; Veiled Cells; Visualization; Widespread Disease; Woman; Work; Zygotes, Plant; abstracting; acute disease/disorder; acute disorder; adhesin; antibiotic resistant; bacterial disease; base; biofilm; biological signal transduction; cytokine; design; designing; disease/disorder; experience; experiment; experimental research; experimental study; extracellular; facial; fimbriae; granulocyte; hToll; heavy metal Pb; heavy metal lead; host response; immunoresponse; living system; macrophage; methicillin resistant; micturition; mouse model; mouse mutant; mucosal site; multi-photon; mutant; neutrophil; nosocomial UTI; nosocomial urinary tract infection; ontogeny; pathogen; pilus; prevent; preventing; psychological defense mechanism; recruit; regenerate; research study; response; seed; social role; sterile; thymus derived lymphocyte; toll-like receptor 4; uRNA; urethral; urinary; urinary bladder; urinary bladder disorder; voiding",MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERS,,51406,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,13,319770,
7749940,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK051526-14,,NIDDK:300762;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"HAJNOCZKY, GYORGY ;",1874115;,5R01DK051526,08/20/1996,12/31/2010,"ATPase, Actin-Activated; Adenosine Triphosphatase, Myosin; Blood Coagulation Factor IV; Buffers; Ca++ element; Calcium; Calcium Ion Signaling; Calcium Signaling; Calcium Spikes; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Communication and Signaling; Cell Death; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Coagulation Factor IV; Communication; Coupling; Crosslinker; Cytoplasm; Cytoplasmic Membrane; Data; Development; Down-Regulation, Receptor; Elements; Endocrine Gland Secretion; Endoplasmic Reticulum; Endoplasmic Reticulum, Granular; Energy Expenditure; Energy Metabolism; Ergastoplasm; Evaluation; Event; Factor IV; GFAC; Genetic Alteration; Genetic Change; Genetic defect; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hormones; IP3R; IP3R1; ITPR1; ITPR1 gene; Image; Immunoelectron Microscopy; Insp3r1; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Ion Transport; Knockout Mice; Label; METBL; MYH12 protein, human; MYO5A protein; MYO5A protein, human; Measures; Mediating; Membrane; Membrane Transport Proteins; Membrane Transporters; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Microtubules; Mitochondria; Mitochondrial Proteins; Modeling; Molecular; Monitor; Motility; Motility, Cellular; Movement; Mutation; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosin Type V; Myosin V; Myosins; Null Mouse; Organelles; Outer Mitochondrial Membrane; Pathologic Processes; Pathological Processes; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Plasma Membrane; Programs (PT); Programs [Publication Type]; Proteins; RER; RNA, Small Interfering; Receptor Down-Regulation; Receptor Protein; Regulation; Research Personnel; Research Support; Researchers; Role; Rough ER; Rough endoplasmic reticulum; Rough-Surfaced Endoplasmic Reticulum; Scheme; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Spikes, Calcium; Structure; Subcellular Process; Testing; Therapeutic Hormone; Time; biological signal transduction; body movement; cartilage link protein; cell motility; dilute protein; fluorescence imaging; fluorophore; gene product; genome mutation; human MYO5A protein; imaging; imaging modality; knock-down; link protein; membrane structure; mitochondrial; mutant; myosin ATP phosphohydrolase (actin translocating); myosin VA (heavy polypeptide 12, myoxin) protein, human; myosin Va; myoxin; necrocytosis; new approaches; novel; novel approaches; novel strategies; novel strategy; plasmalemma; programs; receptor; response; siRNA; small molecule; social role; spatial relationship; uptake",Mechanisms of Pulsatile Calcium Signaling,,51526,CSF,Cell Structure and Function Study Section,,14,300762,
7760125,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK052334-13,,NIDDK:311528;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,SURGERY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BEAUCHAMP, ROBERT D.;",1902873;,5R01DK052334,06/01/1997,01/31/2012,"Animal Welfare; Apoptosis; Apoptosis Pathway; Articulation; Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; Bibliography; Biological Function; Biological Process; Boxing; COX-2; COX2; Cancer Induction; Carcinoma of the Large Bowel; Carcinoma of the Large Intestine; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cellular Proliferation; Clinical Trials; Clinical Trials, Unspecified; Colon; Colon Cancer; Colon Carcinoma; Colon or Rectum; Colonic Carcinoma; Colorectal; Colorectal Cancer; Colorectal Carcinomas; Colorectal Neoplasms; Country; Dinoprostone; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Ecological impact; Environment; Environmental Impact; Epithelial; Equipment; Ethics Committees, Research; Gene Expression; Gene Targeting; Generalized Growth; Goals; Growth; Heumann brand of celecoxib; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intestinal; Intestines; Intracellular Communication and Signaling; Joints; Large Intestine Carcinoma; Large Intestine Neoplasm; Large Intestine Tumor; Link; Mack brand of celecoxib; Malignant Cell; Man (Taxonomy); Man, Modern; Mesenchymal; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mucosa; Mucosal Tissue; Mucous Membrane; Names; Neoplasm Metastasis; Neoplasm of the Large Bowel; PGE2; PGE2 alpha; PGE2alpha; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Parke Davis brand of celecoxib; Pathway interactions; Pfizer brand of celecoxib; Pharmacia Spain brand of celecoxib; Pharmacia brand of celecoxib; Phenotype; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandins; Prostanoids; Research; Research Ethics Committees; Research Resources; Resources; Role; Searle brand of celecoxib; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Stream; Targetings, Gene; Testing; Tissue Growth; Tumor Cell Migration; Tumor Suppressor Proteins; Tumor of the Large Bowel; Tumors, Colorectal; Vertebrate Animals; Vertebrates; abstracting; adenoma; angiogenesis; base; biological signal transduction; bowel; cancer cell; cancer metastasis; cancer progression; carcinogenesis; celebrex; celecoxib; clinical investigation; colorectal neoplasia; design; designing; disease/disorder; enzyme activity; expiration; hCOX-2; human subject; in vivo; mRNA Expression; neoplasm progression; neoplastic progression; notch; notch protein; notch receptors; novel therapeutic intervention; ontogeny; overexpression; pathway; programs; restoration; social role; tumor; tumor progression; tumor suppressor; vertebrata",Intestinal Growth Control,,52334,ZRG1,Special Emphasis Panel,,13,311528,
7754877,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK052852-12,,NIDDK:365904;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,BIOCHEMISTRY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"MCGRAW, TIMOTHY E;",1905775;,5R01DK052852,09/01/1997,12/31/2011,"Adipocytes; Adipose Cell; Animal Welfare; Area; Assay; Behavior; Bibliography; Bioassay; Biologic Assays; Biological Assay; Biology; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cell surface; Chimera; Chimera organism; Country; Cytoplasmic Membrane; Ecological impact; Energy Expenditure; Energy Metabolism; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exocytosis; Fat Cells; Fats; Fatty acid glycerol esters; Fluorescence Microscopy; Funding; GLUT4; GLUT4 gene; Glucose Binding Protein; Glucose Transporter; Humulin R; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; International; Intracellular Communication and Signaling; Isoforms; Kinetic; Kinetics; Learning; Link; Lipocytes; Mature Lipocyte; Mature fat cell; Measures; Membrane Protein Traffic; Membrane Traffic; Methods; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular; Molecular Target; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Mutate; Myocytes; Names; Novolin R; Obesity; Paper; Pathway interactions; Plasma Membrane; Population; Prevalence; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Isoforms; Proteins; RNA, Small Interfering; Recruitment Activity; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Retrieval; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Sorting - Cell Movement; Specificity; Transport Protein, Glucose; United States; Vertebrate Animals; Vertebrates; Work; abstracting; adiposity; base; biological signal transduction; blood glucose regulation; corpulence; corpulency; corpulentia; expiration; gene product; glucose control; glucose homeostasis; glucose regulation; glucose uptake; human subject; insulin resistant; insulin signaling; knock-down; mutant; novel; obese; obese people; obese person; obese population; pathway; plasmalemma; programs; recruit; siRNA; social role; sorting; therapeutic development; trafficking; vertebrata",Insulin Regulated Membrane Trafficking,,52852,ZRG1,Special Emphasis Panel,,12,365904,
7761711,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK052916-13,,NIDDK:359733;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,PHARMACOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"HUBBARD, STEVAN R.;",6709365;,5R01DK052916,09/01/1997,01/31/2011,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]protein-tyrosine O-phosphotransferase; Agonist; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; C-terminal; Cell Communication and Signaling; Cell Signaling; Cells; Complex; Coupling; Crystallographies; Crystallography; Cytoplasmic Domain; Cytoplasmic Tail; DNA Sequence Rearrangement; Dephosphorylation; Developed Countries; Developed Nations; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Event; External Domain; Extracellular Domain; Generalized Growth; Glycoproteins; Goals; Growth; HEK3; HIRS-1; Humulin R; INSR; IRS1; IRS1 gene; IRS2; IRS2 gene; IRTK enzyme; In Vitro; Industrialized Countries; Industrialized Nations; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intracellular Communication and Signaling; Investigators; Kinases; Kinetic; Kinetics; L-Tyrosine; MODY; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Metabolic; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; N-terminal; NH2-terminal; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; PH Domain; PI-3 Kinase; PI-3K; PI3-Kinase; PTB Domain; PTK; PTP-1B; PTP1B; PTPN1; PTPN1 gene; PTPRT protein, human; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphotransferases; Phosphotyrosine Binding Domain; Pleckstrin-Homology Domain; Prevalence; Process; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Family; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Phosphatase Receptor Type T; Proteins; PtdIns 3-Kinase; R-PTP-T; RPTP Rho; Rearrangement; Receptor Activation; Receptor Protein; Receptor Protein Tyrosine Phosphatase; Recruitment Activity; Research Personnel; Researchers; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Specificity; Structure; T2D; T2DM; TYR; Techniques; Therapeutic; Tissue Growth; Tissues; Transphosphorylases; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; Tyrosine; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine Phosphorylation Site; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; adapter protein; adult onset diabetes; base; biological signal transduction; design; designing; diabetic; gene product; human PTPRT protein; hydroxyaryl protein kinase; in vivo; inhibitor; inhibitor/antagonist; insulin receptor tyrosine kinase; insulin signaling; insulin-induced receptor tyrosine kinase; ketosis resistant diabetes; maturity onset diabetes; member; ontogeny; para-Tyrosine; programs; receptor; receptor binding; receptor protein tyrosine phosphatase rho; recruit; small molecule; social role; tyrosyl protein kinase",Structural Study of the Insulin Receptor Tyrosine Kinase,,52916,MSFC,Macromolecular Structure and Function C Study Section,,13,359733,
7738490,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK053434-12,,NIDDK:305298;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"PISTON, DAVID W.;",1883367;,5R01DK053434,01/01/1998,11/30/2010,"Accounting; Action Potentials; Alleles; Allelomorphs; Alpha Cell; Antidiabetic Hormone; Antimorphic mutation; B9 endocrine pancreas; Behavior; Biochemical; Biological; Blood; Blood Glucose; Blood Sugar; Body Tissues; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell membrane; Cell-to-Cell Interaction; Cells; Communicating Junction; Communication; Coupled; Coupling; Cytoplasmic Membrane; D-Glucose; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drugs; Event; Exhibits; Feedback; Fluorescence; Fluorescence Microscopy; Funding; GCG; Gap Junctions; Giant Cells; Glucagon; Glucagon (1-29); Glucagon Cell; Glucagon Secreting Cell; Glucose; Glukagon; Goals; HG-Factor; Human; Human, General; Humulin R; Hyperglycemic-Glycogenolytic Factor; IDD; IDDM; Image; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Ions; Islands of Langerhans; Islet Cells; Islets of Langerhans; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knockout Mice; Lead; Life; Low-resistance Junction; METBL; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Medication; Membrane; Membrane Potentials; Metabolic; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular; Molecular Dynamics Simulation; Motivation; Multinucleated Giant Cells; Murine; Mus; NIDDM; Nature; Nesidioblasts; Nexus; Nexus Junction; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Pancreas, Endocrine; Pancreatic Islets; Paracrine Communication; Paracrine Signaling; Pars endocrina pancreatis; Pathology; Pathway interactions; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Plasma Membrane; Play; Polykaryocytes; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Relative; Relative (related person); Research; Resting Potentials; Reticuloendothelial System, Blood; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Syncytium; T1 diabetes; T1D; T1DM; T2D; T2DM; Techniques; Testing; Time; Tissues; Transgenic Mice; Transgenic Organisms; Transmembrane Potentials; Transplantation; Type 1 diabetes; Type 2 diabetes; Type II diabetes; Work; adult onset diabetes; base; beta cell development; biological signal transduction; blood glucose regulation; cell type; drug/agent; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; gap junction channel; glucose control; glucose homeostasis; glucose regulation; heavy metal Pb; heavy metal lead; imaging; imaging modality; in vivo; insulin dependent diabetes; insulin secretion; interstitial; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; maturity onset diabetes; membrane structure; molecular dynamics; mouse model; novel; optic imaging; optical imaging; pancreatic islet function; paracrine; pathway; plasmalemma; research study; response; social role; success; transgenic; transplant; type I diabetes",Dynamics of Pancreatic Islet Function,,53434,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,12,305298,
7760955,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK054208-11,,NIDDK:284414;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,JOHNSON CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,051125037,US,TN,37614,EAST TENNESSEE STATE UNIVERSITY,"LESAGE, GENE D;",2063994;,5R01DK054208,09/30/2000,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 3'5'-cyclic ester of AMP; APF-1; ASBT protein; ATP-Dependent Proteolysis Factor 1; Absorption; Acetates; Acids, Bile; Acute; Adenosine; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Antibodies; Antimorphic mutation; Apical; Back; Bile; Bile Acids; Bile Duct Obstruction; Bile Ducts; Bile Juice; Bile duct structure; Bile fluid; Biliary Stasis; Biology; Biotinylation; Blotting, Western; Carrier Proteins; Cell Line; Cell Lines, Strains; CellLine; Cells; Cholestasis; Cyclic AMP; DNM1 Gene Product, Dynamin; Data; Dephosphorylation; Development; Distal part of ileum; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Due Process; Dyn1; Dynamin D100; Dynamin I; Dynamin-1; Electron Microscopy; Endocytosis; Endosomes; Epithelial Cells; Event; Exocytosis; Fluorescence Microscopy; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic defect; Growth; HMG-20; Hepatic Disorder; High Mobility Protein 20; INFLM; Inflammation; Intrahepatic bile duct; Investigators; Kidney Tubules; L-Lysine; L-Methionine; Label; Length of Life; Life; Liver diseases; Longevity; Lysine; MDCK cell; Macropain; Macroxyproteinase; Madin Darby canine kidney cell; Measures; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic; Metabolic Glycosylation; Methionine; Methionine, L-Isomer; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Monoubiquitination; Multicatalytic Proteinase; Mutation; Normal Cell; Phosphorylation; Phosphorylation Site; Physiologic pulse; Polyubiquitination; Post-Translational Modifications; Post-Translational Protein Processing; Post-Translational Regulation; Posttranslational Modifications; Posttranslational Regulation; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Dephosphorylation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Turnover; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteosome; Pulse; Receptosomes; Recycling; Regulation; Renal tubule structure; Research Personnel; Researchers; Resistance; Site; Surface Proteins; Techniques; Temperature; Terminal Ileum; Testing; Tissue Growth; Transport Proteins; Transporter Protein; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Western Blotting; Western Blottings; Western Immunoblotting; absorption; adenosine 3'5' monophosphate; apical membrane; apical sodium-dependent bile acid transporter; bile acid transporter; bile duct; bile ductule; bile obstruction; bile occlusion; cAMP; cholangiocyte; cultured cell line; gene product; genome mutation; glycosylation; hepatopathy; inhibitor; inhibitor/antagonist; insight; life span; lifespan; liver disorder; loss of function; membrane structure; multicatalytic endopeptidase complex; mutant; new technology; ontogeny; phorbol myristic acid; phorbol-12-myristate; polarized cell; programs; protein blotting; protein degradation; protein expression; renal tubule; resistant; response; trafficking; ubiquination; ubiquitin conjugation",Bile Acid Modulation of Bile Duct Secretion and Growth,,54208,HBPP,Hepatobiliary Pathophysiology Study Section,,11,284414,
7765494,R01,DK,5,,02/01/2010,01/31/2011,PA-01-112,5R01DK054602-11,,NIDDK:284726;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,VALHALLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,18,041907486,US,NY,10595,NEW YORK MEDICAL COLLEGE,"GOLIGORSKY, MICHAEL S;",1881247;,5R01DK054602,01/01/1999,01/31/2011,"2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 3-mononitrotyrosine; 3-nitrotyrosine; AGE receptor; ARF; Advanced Glycosylation End Products; Aging Process; Aging, Premature; Aging-Related Process; Animals; Antioxidants; Apoptosis; Apoptosis Pathway; Apoptotic; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biochemical; CDK4I; CDKN2; CDKN2A; CDKN2A gene; CMM2; Cachectin; Cachectin-Tumor Necrosis Factor; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Aging; Cell Count; Cell Culture Techniques; Cell Cycle; Cell Death, Programmed; Cell Division Cycle; Cell Number; Cell Senescence; Cell Size; Cells; Cellular Aging; Cessation of life; Clinical Trials, Phase II; Collagen; Common Rat Strains; Cyclin-Dependent Kinase Inhibitor 2A Gene; Death; Deceleration; Development; Diabetes Mellitus; Dysfunction; Endothelial Cells; Enrollment; Epidemic; Event; Extracellular Matrix Proteins; Extravasation; Fats; Fatty acid glycerol esters; Fructose; Functional disorder; Galactosidase; Gangliosides; General Population; General Public; Genes, CDKN2; Genes, p16; Genes, p16INK4A; Genes, p53; Glycation End Products, Advanced; Glycosylation End Products, Advanced; Human; Human, General; INK4; INK4A; IVFM; Image Analyses; Image Analysis; In Vitro; Incidence; Insulin Resistance; Investigation; Kidney; Kidney Diseases; Lead; Leakage; Levulose; Life; Light; MLM; MTS1; MTS1 Genes; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Metabolic syndrome; Methods and Techniques; Methods, Other; Mice; Microcirculation; Microscopy, Video; Mitochondria; Modeling; Molecular; Molecular Target; Morphology; Murine; Mus; Nephropathy; North America; Obesity; Organ System, Cardiovascular; OxLDL; Oxidative Stress; Oxygen Consumption; P53; PKC; Pathway interactions; Patients; Pb element; Permeability; Peroxonitrite; Peroxonitrites; Peroxynitrites; Phase 2 Clinical Trials; Phase II Clinical Trials; Phenotype; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Photoradiation; Physiopathology; Population; Premature aging syndrome; Prevention; Production; Protein Kinase C; Proteins; RAGE receptor; ROC Analysis; Rat; Rat model of diabetes; Rattus; Renal Disease; Role; Senescence, Cellular; Senescence, Replicative; Sialoglycosphingolipids; Spillage; Superoxide Anion; Superoxide Radical; Superoxides; Syndrome; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; TP16; TP53; TP53 gene; TRP53; TSG9A; Techniques; Treatment Efficacy; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Tumor Protein p53 Gene; Umbilical vein; Urinary System, Kidney; Vascular Diseases; Vascular Disorder; Vascular, Heart; Video Microscopy; Videomicrography; Videomicroscopy; adiposity; advanced glycation endproduct; advanced glycosylation end-product receptor; amphoterin receptor; anti-oxidant; antioxidant therapy; atheromatosis; atherosclerotic vascular disease; base; blood vessel disorder; circulatory system; corpulence; corpulency; corpulentia; design; designing; diabetes; diabetic; diabetic rat; diabetic rat model; ebselen; enroll; experiment; experimental research; experimental study; feeding; gene product; heavy metal Pb; heavy metal lead; human TNF protein; image evaluation; in vivo; insulin resistant; intravital fluorescence microscopy; kidney disorder; mitochondrial; mitochondrial dysfunction; nitrotyrosine; non-diabetic; nondiabetic; obese; obese people; obese person; obese population; ox-LDL; oxidized LDL; oxidized low density lipoprotein; p14ARF; p16INK4 Genes; p16INK4a; pathophysiology; pathway; peroxynitrite; phase 2 study; phase 2 trial; phase II trial; premature; prevent; preventing; protocol, phase II; receptor for advanced glycation endproducts; renal; renal disorder; research study; senescence; social role; study, phase II; therapeutic efficacy; therapeutically effective; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROME,,54602,PBKD,Pathobiology of Kidney Disease Study Section,,11,284726,
7738489,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK055310-09,,NIDDK:281033;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"COBB, MELANIE H;",1887074;,5R01DK055310,09/30/1998,11/30/2010,"Address; Affect; Binding; Binding (Molecular Function); Biological Preservation; Biology; C-EBP Nuclear Protein; C-EBP Proteins; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; Calcineurin; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical, Transplantation, Organ; Complex; D-Glucose; DNA Binding; DNA Binding Interaction; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Drug usage; Dysfunction; EC 2.7.2-; ERK1; ERK2; ERT1; Event; Extracellular Signal-Regulated Kinases; Fibroblasts; Functional disorder; Gastrointestinal Tract, Pancreas; Gene Transcription; Genes; Genetic Transcription; Glucose; Goals; Grafting Procedure; Health; Hormonal; Hour; Humulin R; Hyperglycemia; Immune; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Investigators; Knowledge; MAP kinase; MAPK; MAPK1; MAPK1 gene; MAPK2; MAPK3; MAPK3 gene; MODY; Maintenance; Maintenances; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Messenger RNA; Mice; Mitogen-Activated Protein Kinase 3 Gene; Mitogen-Activated Protein Kinases; Molecular Interaction; Murine; Mus; Mutate; NIDDM; Natural immunosuppression; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nuclear; Nutrient; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; P41MAPK; P42MAPK; P44ERK1; P44MAPK; PP2B; PRKM1; PRKM2; Pancreas; Pancreatic; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Physiology; Physiopathology; Preservation, Biologic; Preservation, Biological; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphatase-2B; Protein Phosphorylation; Protein phosphatase; Proteins; QOL; Quality of life; RNA Expression; RNA, Messenger; Regulation; Repression; Research; Research Personnel; Researchers; Role; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Subcellular Process; System; System, LOINC Axis 4; T2D; T2DM; Transcription; Transcription, Genetic; Transplantation; Transplantation Surgery; Type 2 diabetes; Type II diabetes; United States; adult onset diabetes; base; biological adaptation to stress; biological signal transduction; cost; diabetes; diabetic; drug use; gene product; human disease; hyperglycemic; immunosuppression; immunosuppressive; islet; ketosis resistant diabetes; mRNA; maturity onset diabetes; organ allograft; organ graft; organ xenograft; overexpression; pathophysiology; preservation; prevent; preventing; programs; reaction; crisis; response; social role; stress response; stress; reaction; transcription factor; transplant",MAP Kinse in Islet Function,,55310,ZRG1,Special Emphasis Panel,,9,281033,
7743768,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK055664-08,,NIDDK:311355;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOUISVILLE,UNITED STATES,SURGERY,03,057588857,US,KY,40292,UNIVERSITY OF LOUISVILLE,"HARBRECHT, BRIAN G.;",2097550;,5R01DK055664,02/15/2001,11/30/2012,"21+ years old; 3'5'-cyclic ester of AMP; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adult; Antidiabetic Hormone; Area; Biology; Blood Coagulation Factor IV; Blood Glucose; Blood Sugar; Body Tissues; Ca++ element; Calcium; Caring; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Chemotherapy-Hormones/Steroids; Circulatory Collapse; Coagulation Factor IV; Complex; Critical Care; Critical Illness; Critically Ill; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Death; Development; Dysfunction; Endocrine Gland Secretion; Endocrinology; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Event; Factor IV; Functional disorder; GCG; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GTP GDP exchange factor; Glucagon; Glucagon (1-29); Glukagon; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; HG-Factor; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hepatocyte Nitric Oxide Synthase; Hormones; Human, Adult; Humulin R; Hyperglycemic-Glycogenolytic Factor; INFLM; INOS; Immune; Immune response; In Vitro; Inducible Nitric Oxide Synthase; Infection; Inflammation; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Lead; Liver Cells; METBL; MOF syndrome; Macrophage Nitric Oxide Synthase; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Processes; Metabolism; Metabolism and Endocrinology; Molecular; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Multiple Organ Failure; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Novolin R; Nuclear; Nutrition; Nutritional Science; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organ Dysfunction Syndrome, Multiple; PKA; Pathway interactions; Patients; Pb element; Physiologic; Physiological; Physiopathology; Production; Programs (PT); Programs [Publication Type]; Protein Kinase A; Regulation; Research; Role; Science of nutrition; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Sepsis; Septic Shock; Series; Shock; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Study Section; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Therapeutic Hormone; Tissues; Transplantation; Work; abstracting; adenosine 3'5' monophosphate; adult human (21+); base; biological signal transduction; bloodstream infection; cAMP; cAMP-Dependent Protein Kinases; circulatory shock; cytokine; endothelial cell derived relaxing factor; exchange factor; heavy metal Pb; heavy metal lead; host response; human NOS2A protein; iNOS enzyme; immunoresponse; improved; in vivo; multiple organ system failure; nitric oxide synthase, Type II; novel; nutrition; pathophysiology; pathway; prevent; preventing; programs; response; septic; social role; surgery; transplant",Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin,,55664,SAT,"Surgery, Anesthesiology and Trauma Study Section",,8,311355,
7752506,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK055679-12,,NIDDK:368280;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"NUSRAT, ASMA ;",1892311;,5R01DK055679,08/01/1998,01/31/2014,"ATGN; Actin-Binding Protein; Actins; Acute; Annexins; Antibodies; Antigens; Antimorphic mutation; Assay; Autoregulation; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Blotting, Western; Body Tissues; Calcimedins; Cell Attachment; Cell Communication and Signaling; Cell Culture Techniques; Cell Fractionation; Cell Locomotion; Cell Migration; Cell Movement; Cell Polarity; Cell Signaling; Cell surface; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Migration; Colitis; Complex; Confocal Microscopy; Data; Defect; Development; Dextran Sulfate; Dextran, hydrogen sulfate; Disease Progression; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Electrolytes; Embryo; Embryonic; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Extracellular Matrix, Integrins; FADK; FAK; FAK1; Family member; Goals; Gut Epithelium; Homeostasis; INFLM; Immune Precipitation; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Immunoprecipitation; In Vitro; Individual; Inflammation; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Injury; Integrins; Intestinal; Intestines; Intracellular Communication and Signaling; Investigation; Ischemia; LIM Domain Kinase 1; LIM kinase; LIMK protein; LIMK-1; LIMK1; Label; Lipid Rafts, Cell Membrane; Lipocortins; Liquid substance; Mammals, Mice; Membrane; Membrane Microdomains; Mice; Microscopy, Confocal; Modeling; Motility; Motility, Cellular; Mucosa; Mucosal Tissue; Mucous Membrane; Murine; Mus; N-terminal; NH2-terminal; PTK2; PTK2 gene; Pathologic Processes; Pathological Processes; Peptides; Permeability; Phosphorylation; Physiological Homeostasis; Play; Process; Protein Phosphorylation; Proteins; RNA, Small Interfering; Recombinant Antibody; Recovery; Recycling; Regulation; Regulatory Protein; Rho-associated kinase; Rho-kinase; Role; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stream; Structure of intestinal epithelium; Surface; Testing; Therapeutic Agents; Tissues; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; Wound Healing; Wound Repair; biological signal transduction; bowel; cell motility; cellular polarity; cofilin; experiment; experimental research; experimental study; fluid; gastrointestinal epithelium; gene product; genetic regulatory protein; immunogen; in vivo; injury response; intestinal epithelium; lipid raft; liquid; membrane structure; migration; mutant; new therapeutics; next generation therapeutics; novel therapeutics; pathogen; paxillin; polarized cell; pp125FAK; protein activation; protein blotting; protein complex; protein distribution; public health relevance; regulatory gene product; research study; response to injury; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; siRNA; social role; subcellular fractionation; tissue repair; wound",Intestinal Mucosal Wound Resealing in IBD," PROJECT NARRATIVE The gastrointestinal epithelium functions as an important barrier that separates luminal contents from underlying tissue compartments. Disruption of the epithelial barrier in inflammatory bowel diseases and ischemia result in fluid & electrolyte loss and exposure of tissues to luminal antigens and pathogens. To rapidly reseal such wounds, epithelial cells migrate in a process termed restitution. Our studies are aimed at understanding mechanisms by which the intestinal epithelium migrates to rapidly cover denuded surfaces and reseal wounds. We recently determined that two proteins, annexin-2 and Dickkopf-1 control intestinal epithelial cell migration and wound recovery. The proposed studies will analyze the mechanisms by which these proteins regulate intestinal epithelial wound recovery. These investigations will not only define the mechanisms by which these proteins regulate wound resealing, but will also provide new ideas to identify therapeutic agents aimed at promoting intestinal epithelial wound closure and mucosal barrier recovery.",55679,ZRG1,Special Emphasis Panel,,12,368280,
7743770,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK055710-09,,NIDDK:298337;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"BEZERRA, JORGE A.;",1892297;,5R01DK055710,09/01/2000,11/30/2010,"Abscission; Anaplastic; Architecture; Award; Biological; Biology; Body Tissues; Bone Marrow; Cell Communication and Signaling; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Migration; Cellular Proliferation; Cues; Data; Development; EC 3.4.21.7; ECM; Embryo; Embryonic; Endocrine; Engineering / Architecture; Environment; Esteroproteases; Event; Excision; Exocrine pancreas; Extirpation; Extracellular Matrix; Family suidae; Fibrin; Fibrinolysin; Fostering; Gastrointestinal Tract, Pancreas; Generalized Growth; Genetic Algorithm; Genetic Programming; Genetically Engineered Mouse; Glu-Plasmin; Goals; Growth; HGF/SF; Health; Hepatic; Hepatic Cells; Hepatic Failure; Hepatic Parenchymal Cell; Hepatic Stellate Cell; Hepatocyte; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; Human; Human, General; In Vitro; Injury; Injury to Liver; Intracellular Communication and Signaling; Investigators; Ito Cell; Liver; Liver Cells; Liver Failure; Liver Stem Cell; Liver cell necrosis; Lobular; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Molecular; Molecular Target; Mother Cells; Motility; Motility, Cellular; Murine; Mus; Necrosis; Necrotic; Organ; PLAU; Pancreas; Pancreatic; Partial Hepatectomy; Patients; Peptidases; Peptide Hydrolases; Phenotype; Pigs; Plasmin; Plasminogen; Plasminogen Activator; Plasminogen Activator, Urokinase; Play; Process; Production; Profibrinolysin; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protease F; Proteases; Proteinases; Proteolytic Clipping; Proteolytic Enzymes; Proteolytic Processing; Receptor Protein; Removal; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Role; Scatter Factor; Series; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; Suidae; Surgical Removal; Swine; System; System, LOINC Axis 4; Tissue Growth; Tissues; U-PA; U-Plasminogen Activator; UPA; Undifferentiated; Urinary Plasminogen Activator; Urokinase; Urokinase-Type Plasminogen Activator; Work; biological signal transduction; body system, hepatic; cell motility; deprivation; developmental plasticity; experiment; experimental research; experimental study; extracellular; hepatic cell proliferation; hepatic cellular proliferation; hepatocyte cell proliferation; hepatocyte cellular proliferation; hepatocyte proliferation; in vitro Assay; in vivo; insight; liver cell proliferation; liver cellular proliferation; liver function; meetings; migration; mouse model; necrotic liver cell; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; organ system, hepatic; overexpression; partial excision of liver; porcine; progenitor; programs; receptor; repair; repaired; research study; resection; response; social role; stem cell biology; subtotal hepatectomy; suid; synergism; therapeutic target; transcription factor",The plasminogen system and liver repair,,55710,ZRG1,Special Emphasis Panel,,9,298337,
7768414,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK056112-10,,NIDDK:287511;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GREENVILLE,UNITED STATES,MISCELLANEOUS,03,607579018,US,NC,27858,EAST CAROLINA UNIVERSITY,"HOUMARD, JOSEPH A;",1970344;,5R01DK056112,08/15/2000,01/31/2011,"Address; Body Weight decreased; CSBP1; CSBP2; CSPB1; Cell Culture Techniques; Clinical; Data; Defect; Depressed mood; Drugs; Dysfunction; EXIP; Enzymes; Equilibrium; Exercise; Exercise, Physical; Exposure to; Extracellular Signal-Regulated Kinase Gene; Family; Fatty Acids; Functional disorder; Gene Transcription; Genes; Genetic Transcription; Human; Human, General; Impairment; Individual; Insulin Resistance; Intervention; Intervention Strategies; Intramuscular; Investigators; Laboratories; Lipids; MAP Kinase Gene; MAPK; MAPK14; MAPK14 gene; Man (Taxonomy); Man, Modern; Mediating; Medication; Metabolic; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Fibers; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Mxi2; Myocytes; Myotubes; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Obesity; Oxidative Regulation; PPAR; PRKM14; PRKM15; Pathway interactions; Peroxisome Proliferator-Activated Receptors; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Play; Programs (PT); Programs [Publication Type]; RNA Expression; Regulation; Research Personnel; Researchers; Rhabdomyocyte; Role; SAPK2A; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Stimulus; Stress; System; System, LOINC Axis 4; Testing; Training; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Weight Loss; Weight Reduction; adiposity; balance; balance function; body weight loss; corpulence; corpulency; corpulentia; depressed; drug/agent; extracellular; fat metabolism; fatty acid oxidation; flexibility; genetic manipulation; in vivo; insulin resistant; intervention effect; interventional strategy; lipid metabolism; obese; obese people; obese person; obese population; overexpression; oxidation; oxidized lipid; p38; p38 MAPK Gene; p38Alpha; pathophysiology; pathway; programs; response; sadness; social role; weight loss intervention; wt-loss",Lipid metabolism in obesity weight loss and exercise,,56112,ZRG1,Special Emphasis Panel,,10,287511,
7755424,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK056598-25,,NIDDK:311355;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAPEL HILL,UNITED STATES,NUTRITION,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"COLEMAN, ROSALIND ANNE;",1899211;,5R01DK056598,04/01/1985,12/31/2011,"1,2-diacylglycerol; 1-acyl-sn-glycerol-3-phosphate; 1-oleoyl-lysophosphatidic acid; 1-phosphoglycerol; Acyl CoA; Acyl Coenzyme A; Acyl-CoA Sn-Glycerol-3-Phosphate-O-Acyltransferase; Acyl-CoA[{..}]sn-glycerol-3-phosphate 1-O-acyltransferase; Adipose tissue; Body Tissues; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Carbohydrates; Cell Communication and Signaling; Cell Signaling; Cells; Commit; Complex; Cultured Cells; DAG; Data; Diacylglycerols; Dietary Carbohydrates; Dietary Fats; Diglycerides; Endoplasmic Reticulum; Enzymes; Ergastoplasm; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fats; Fatty Acids; Fatty Acyl CoA; Fatty Liver; Fatty Tissue; Fatty acid glycerol esters; Funding; Glycerol-3-Phosphate O-Acyltransferase; Glycerol-3-phosphate acyltransferase; Glycerolipid Metabolism; Glycerolipid Metabolism Pathway; Glycerolphosphate Acyltransferase; Glycerophosphate Acyltransferase; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Isoforms; Knockout Mice; LPA; Link; Lipids; Lipoproteins; Lipoproteins, VLDL; Liver; Liver Cells; Liver Steatosis; Long-Chain Acyl CoA; Lysophosphatidic Acids; Lysophospholipids; METBL; MOPA; Mammals, Rodents; Mediating; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Mitochondria; Muscle; Muscle Tissue; Novolin R; Null Mouse; Nutrient; PKC; Pathology; Pathway interactions; Peripheral; Phosphatides; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phospholipids; Physiologic; Physiological; Position; Positioning Attribute; Prebeta-Lipoproteins; Process; Production; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase C; RAFT-1 gene product; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Regulation; Resistance; Rodent; Rodentia; Rodentias; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Stearyl-CoA Glycerophosphate Transstearylase; Steatohepatitis; Tissues; Triacylglycerol; Triglycerides; VLDL; VLDL triacylglycerol; VLDL triglyceride; Very low density lipoprotein; Work; adipogenesis; adipose; alpha-glycerophosphate; alpha-glycerophosphoric acid; biological signal transduction; body system, hepatic; design; designing; diacylglycerol; dietary lipid; diglyceride; gain of function; glycerol 1-phosphate; glycerol 3-phosphate; hepatic steatosis; human FRAP1 protein; insulin resistant; insulin sensitivity; insulin signaling; lipid biosynthesis; lipogenesis; lipoprotein, VLDL triglyceride; loss of function; lysophosphatidic acid; mTOR; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); mitochondrial; monooleylphosphatidate; monooleylphosphatidic acid; organ system, hepatic; oxidation; particle; pathway; rapamycin and FKBP12 target 1 protein, human; resistant; response; tool; very low density lipoprotein triglyceride; white adipose tissue; yellow adipose tissue",Metabolism of Glycerolipids in Liver,,56598,INMP,Integrative Nutrition and Metabolic Processes Study Section,,25,311355,
7751896,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK056695-09,,NIDDK:298375;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"PEARCE, DAVID ;",1895355;,5R01DK056695,08/15/2000,12/31/2010,"1-Phosphatidylinositol 3-Kinase; 14-3-3 Family; 14-3-3 Proteins; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Aldosterone; Antibodies; Antigen Binding Fragment; Antigenic Determinants; Antimorphic mutation; Apical; Assay; Behavior; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biotinylation; Blood Pressure, High; Brain 14-3-3 Protein; Cardiac Failure Congestive; Cell membrane; Cell model; Cell surface; Cell/Tissue, Immunohistochemistry; Cells; Cellular model; Cellulose Nitrate; Chaperone; Chemotherapy-Hormones/Steroids; Combining Site; Congestive Heart Failure; Cultured Cells; Cytoplasmic Membrane; Data; Dephosphin; Distal; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dynamin; EC 2.7; ENaC; ENaC (epithelial Na+ channel); Endocrine Gland Secretion; Endocytosis; Epithelial; Epithelium; Epitopes; Event; Exocytosis; Fab Fragments; Fab Immunoglobulins; Figs; Figs - dietary; Fluorescence Microscopy; Genetics, in situ Hybridization; Heart Decompensation; Heart Failure, Congestive; Hormones; Hypertension; IHC; Immunoglobulin, F(ab) Fragment; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin Antagonists; Ion Transport; Isoforms; Kidney; Kinases; Laboratories; Learning; Life; Lipid Binding; Lipids; Liposomal; Liposomes; Location; Lysosomes; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Mediating; Membrane; Metabolic syndrome; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Molecular Chaperones; Molecular Interaction; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Movement; N-terminal; NH2-terminal; Na element; Nephrons; Nitrocellulose; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Plasma Membrane; Play; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Protein Isoforms; Protein Phosphorylation; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; PtdIns; PtdIns 3-Kinase; Pyroxylin; RNA, Small Interfering; Reactive Site; Recycling; Regulation; Role; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Small Interfering RNA; Sodium; Staining method; Stainings; Stains; System; System, LOINC Axis 4; Testing; Therapeutic Hormone; Threonine Kinase; Time; Transphosphorylases; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Urinary System, Kidney; Uriniferous Tube; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Xenopus oocyte; base; body movement; epithelial Na+ channel; gene product; hormonal regulation; hormone regulation; hyperpiesia; hyperpiesis; hypertensive disease; in situ Hybridization Staining Method; inhibitor; inhibitor/antagonist; insulin inhibitor; membrane structure; mutant; novel; pathway; plasmalemma; protein protein interaction; renal; response; salt sensitive; scaffold; scaffolding; siRNA; social role; trafficking; ubiquination; ubiquitin conjugation; ubiquitin ligase",SGK Regulation of Epithelial Sodium Transport,,56695,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,9,298375,
7743761,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK056966-08,,NIDDK:341881;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CAMBRIDGE,UNITED STATES,NONE,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"BHATIA, SANGEETA N.;",6134293;,5R01DK056966,09/30/2000,11/30/2011,"21+ years old; 3-D; 3-Dimensional; Adhesives; Adult; Architecture; Biological; Body Tissues; Cadherins; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell Therapy; Cell-Extracellular Matrix; Cell-to-Cell Interaction; Cells; Chemistry; Chemotherapy-Hormones/Steroids; Chronic; Collaborations; Communicating Junction; Coupled; Cues; Development; Devices; Dimensions; Discontinuous Capillary; Doctor of Philosophy; Drug Interactions; Drugs; Dysfunction; Dysfunction, Liver; ECM; Endocrine Gland Secretion; Engineering; Engineering / Architecture; Engineerings; Equilibrium; Extracellular Matrix; Functional disorder; Future; GFAC; Gap Junctions; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hepatic Cells; Hepatic Disorder; Hepatic Failure; Hepatic Parenchymal Cell; Hepatic Tissue; Hepatocyte; Hepatotoxic effect; Hepatotoxicity; Hormones; Human, Adult; Hydrogels; In Vitro; Intracellular Communication and Signaling; Investigators; Laboratories; Liver; Liver Cell Adhesion Molecules; Liver Cells; Liver Dysfunction; Liver Failure; Liver Toxicity; Liver diseases; Low-resistance Junction; Medication; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Modeling; Natural regeneration; Neoplasm Metastasis; Nexus; Nexus Junction; Nutrient; O element; O2 element; Oxygen; Paracrine Communication; Paracrine Signaling; Pathologic; Pattern; Peptides; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiologic; Physiological; Physiology; Physiopathology; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Regeneration; Research; Research Personnel; Researchers; Role; Science of Chemistry; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Sinusoid; Sinusoidal Capillary; Site; Stimulus; Surface; Techniques; Therapeutic Hormone; Therapy, Cell; Tissues; Toxic effect on liver cells; Tumor Cell Migration; Viral Diseases; Virus Diseases; Work; Xenobiotics; adult human (21+); balance; balance function; base; biological signal transduction; body system, hepatic; cancer metastasis; cell-based therapy; clinical relevance; clinically relevant; design; designing; drug/agent; fluid flow; hepatopathy; hepatoxicity; in vitro Model; in vivo; liver cell adhesion molecule; liver disorder; liver function; novel; organ system, hepatic; pathophysiology; programs; regenerate; response; scaffold; scaffolding; social role; success; tool; transcription factor; viral infection; virus infection",Role of Tissue Micro-Architecture on Hepatocyte Function,,56966,ZRG1,Special Emphasis Panel,,8,341881,
7740215,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK057267-08,,NIDDK:257173;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,UROLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"YOSHIMURA, NAOKI ;",6158937;,5R01DK057267,09/30/1999,11/30/2010,"Afferent Neurons; Afferent Pathways; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Autonomic pain; Award; Axonal Transport; Axoplasmic Transport; Binding; Binding (Molecular Function); Bladder; Body Tissues; C Fiber; CHO Cells; Causality; Cell Line; Cell Lines, Strains; Cell/Tissue, Immunohistochemistry; CellLine; Chinese Hamster Ovary Cell; Chronic; Closure by Ligation; Common Rat Strains; DTX(K); Data; Detection; Development; Disease; Disorder; Dissociation; Dorsal Root Ganglia; ELISA; Enzyme-Linked Immunosorbent Assay; Etiology; Event; Exhibits; Fast Blue; Fiber; Figs; Figs - dietary; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; GFAC; Ganglia, Spinal; Glia; Glial Cells; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HCL; Heterogeneity; Hydrochloric Acid; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; Increased frequency of micturition; Individual; Inflammation; Injection of therapeutic agent; Injections; Injury; Interstitial Cystitis; Investigation; Isolectin; Kolliker's reticulum; Label; Ligation; Lower urinary tract; Mammals, Rats; Measurement; Measures; Mediating; Medulla Spinalis; Metabolic; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Interaction; Muriatic Acid; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve; Nerve Cells; Nerve Growth Factors; Nerve Unit; Nervous; Neural Cell; Neural Pathways; Neurocyte; Neuroglia; Neuroglial Cells; Neuronotrophic Factors; Neurons; Neurons, Afferent; Neurons, Sensory; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Non-neuronal cell; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Pain; Pain Disorder; Painful; Paper; Patient Care; Patient Care Delivery; Pelvic; Pelvic Floor; Pelvic Floor Muscle; Pelvic Pain; Pelvic Region; Pelvic floor structure; Pelvis; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Publishing; RNase protection assay; Rat; Rattus; Regulation; Research; Resistance; Ribosomes; Role; Sensory Cell Afferent Neuron; Spinal Cord; Spinal Ganglia; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Techniques; Tissues; Toxin; Transmission; United States National Institutes of Health; Urethra; Urethral sphincter; Urethritis; Urinary Frequency; Urinary System, Bladder; V (voltage); Vaginal birth; Vaginal delivery; Vaginal delivery procedure; Visceral; Visceral Afferents; Visceral pain; afferent nerve; awake; base; chronic pelvic pain; chronic pelvic pain syndrome; cultured cell line; dendrotoxin; dendrotoxin K; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; dorsal root ganglion; fluorescent dye/probe; gene product; innovate; innovation; innovative; irritation; model organism; nerve cement; nerve injury; neural injury; neuronal; neurotrophic factor; neurotrophin; neutrophin; nociceptive response; patch clamp; programs; resistant; response; sensory nerve; social role; surgery; therapeutic target; tityustoxin; transmission process; treatment strategy; urethral; urinary; urinary bladder; urologic; urological; voltage",Afferent plasticity underlying urethral and pelvic pain,,57267,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,8,257173,
7750018,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK057539-10,,NIDDK:409937;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"ACCILI, DOMENICO ;",6568598;,5R01DK057539,06/01/2000,12/31/2010,"1-Phosphatidylinositol 3-Kinase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Abbreviations; Acetylation; Acetyltransferase; Acute Promyelocytic Leukemia; Address; Adipocytes; Adipose Cell; Animals; Assay; Binding Proteins; Bioassay; Biologic Assays; Biological; Biological Assay; Biology; Boxing; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Cellular Oncogene; Chimera Protein; Chimeric Proteins; Cloning; Cultured Cells; D-Glucose-6-phosphate phosphohydrolase; DNA Binding; DNA Binding Interaction; Data; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EP300; EP300 gene; Enzymes; Equilibrium; Exclusion; Family; Fat Cells; Funding; Fusion Protein; Gastrointestinal Tract, Pancreas; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genetic; Genetic Transcription; Gluconeogenesis; Glucose-6-Phosphate Phosphohydrolase; Goals; Grant; HDAC; HDAC Proteins; Hand; Hepatic; Histone Deacetylase; Human; Human, General; Humulin R; INSR; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; Knock-in; Knock-in Mouse; L-Lysine; Laboratories; Ligand Binding Protein; Link; Lipocytes; Liver; Lysine; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mature Lipocyte; Mature fat cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolism; Methods; Mice; Mice, Transgenic; Murine; Mus; Myeloid Leukemia, Acute, M3; Novolin R; Nuclear; Oxidative Stress; PI-3 Kinase; PI-3K; PI3-Kinase; Pancreas; Pancreatic; Pathway interactions; Phosphates; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Physiologic; Physiological; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Progranulocytic Leukemia; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Turnover; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proto-Oncogenes; PtdIns 3-Kinase; Pyruvate; Pyruvates; RNA Expression; Regulation; Research Personnel; Researchers; Role; Serine Kinase; Serine-Threonine Kinases; Signal Transduction; Signal Transduction Systems; Signaling; Site; Targetings, Gene; Testing; Therapeutic; Thesaurismosis; Threonine Kinase; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenic Mice; Transgenic Organisms; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Work; balance; balance function; base; biological signal transduction; body system, hepatic; c-ONC; cell imaging; cell type; cellular imaging; diabetes; disease/disorder; experiment; experimental research; experimental study; fork head protein; forkhead protein; forkhead transcription factors; gain of function; gene product; glucose RA; glucose biosynthesis; glucose production; glucose rate of appearance; glucose-6-phosphatase; glycogenolysis; hepatic gluconeogenesis; in vivo; inorganic phosphate; insulin signaling; metabolism disorder; mutant; notch; notch protein; notch receptors; novel; organ system, hepatic; p300; pathway; programs; promyelocytic leukemia; protein degradation; protein protein interaction; protooncogene; research study; social role; transcription factor; transgenic",Role of Forkhead Proteins in Insulin Action,,57539,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,10,409937,
7743824,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK057718-08,,NIDDK:236283;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"JOHNSON, JOHN P.;",1897926;,5R01DK057718,04/01/2000,12/31/2011,"APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Antigenic Determinants; Antimorphic mutation; Apical; Autoregulation; Basic Research; Basic Science; Binding; Binding (Molecular Function); Binding Determinants; Biochemical; Blood Pressure, High; Body Tissues; CFTR; CFTR Protein; CURL; Cardiovascular Diseases; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular Membrane; Chemotherapy-Hormones/Steroids; Clathrin; Clathrin Adaptors; Clathrin Assembly Proteins; Clathrin-Associated Adaptors; Clathrin-Associated Proteins; Clathrin-Coated Vesicles; Cleaved cell; Colon; Compartment of the Uncoupling Receptors and Ligands; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Defect; Dephosphin; Deubiquitinating Enzyme; Deubiquitination; Disease; Disorder; Distal; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Duct; Duct (organ) structure; Dynamin; EC 2.7; ENaC; ENaC (epithelial Na+ channel); Early Endosome; Endocrine Gland Secretion; Endocytosis; Epithelial; Epithelial Cells; Epitopes; Equilibrium; Essential Hypertension; Excision; Excretory function; Extirpation; Extracellular Fluid; Fibrosis; Goals; Grant; HGS; HMG-20; Half-Life; Half-Lifes; Hereditary; Hgs protein; High Mobility Protein 20; Homeostasis; Hormones; Hrs protein; Hypertension; Hypertension, Renal; Hypertensive Nephropathy; Individual; Inherited; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Ion Channel; Ionic Channels; Kidney; Kinases; Length; Link; Lipid Rafts, Cell Membrane; Liquid substance; Lung; MDCK cell; Madin Darby canine kidney cell; Maintenance; Maintenances; Mediating; Membrane; Membrane Channels; Membrane Microdomains; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Mono-S; MonoS; Mucoviscidosis; Na element; Nephrons; PIP2; Pathologic; Pathway interactions; Phase; Phosphatases; Phosphatidyl Inositol; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphohydrolases; Phosphoinositides; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiologic; Physiological; Physiological Homeostasis; Play; Polyubiquitination; Population; Probability; Process; Protein Cleavage; Protein Synthesis Inhibition; Proteins; Proteolysis; PtIns 4,5-P2; PtdIns; PtdInsP2; Recruitment Activity; Recycling; Regulation; Relative; Relative (related person); Removal; Renal Hypertension; Research; Respiratory System, Lung; Retrieval; Role; Site; Sodium; Sodium Chloride; Sodium chloride (NaCl); Sorting - Cell Movement; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Structure; Surgical Removal; Syndrome; Techniques; Testing; Therapeutic Hormone; Tissues; Transphosphorylases; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Urinary System, Kidney; Uriniferous Tube; VESCL; VPS; Vacuolar Protein Sorting; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vesicle; Work; airway epithelium; apical membrane; balance; balance function; base; cardiovascular disorder; cleaved; coated pit; cultured cell line; cystic fibrosis transmembrane regulator; design; designing; disease/disorder; epithelial Na+ channel; epsin; excretion; experiment; experimental research; experimental study; fluid; gene product; hemodynamics; hepatocyte growth factor-regulated tyrosine kinase substrate; hrs gene product; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; inhibitor; inhibitor/antagonist; lipid raft; liquid; membrane structure; mutant; overexpression; pathway; primary hypertension; pulmonary; recruit; renal; research study; resection; salt; salt sensitive; social role; sorting; trafficking; ubiquination; ubiquitin conjugation; wasting",Trafficking and Regulation of the Epithelial Na+ Channel,,57718,ZRG1,Special Emphasis Panel,,8,236283,
7759123,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK058763-10,,NIDDK:349444;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BURK, RAYMOND F.;",1892063;,5R01DK058763,05/01/2001,01/31/2011,"0-11 years old; Africa; Animals; Asia; Bioavailability; Biochemical Markers; Biologic Availability; Biological Availability; Blood Plasma; Butanoic acid, 2-amino-4-(methylseleno)-; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Chemicals; Child; Child Youth; Children (0-21); China; Cirrhosis; Clinical Research; Clinical Study; D-Galactose, 2-amino-2-deoxy-; Diet Supplement; Dietary Supplements; Disease; Disorder; Dose; Drugs; Effectiveness; Elements; Equation; Europe; Galactosamine; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Goals; Grant; Health; Hepatic Disorder; Human; Human, Child; Human, General; Incidence; Individual; Infection; Institute of Medicine; Institute of Medicine (U.S.); Intake; Intermediary Metabolism; Knowledge; Liver diseases; METBL; Mainland China; Malnutrition; Man (Taxonomy); Man, Modern; Markers, Biochemical; Measures; Medication; Metabolic Processes; Metabolism; Methods; Micronutrients; Modeling; NAS/IOM; Nutritional Deficiency; Nutritional Requirements; Nutritional Supplement; Nutritional status; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic Availability; Pilot Projects; Plasma; Population; Predisposition; Recommended Dietary Allowance; Relative; Relative (related person); Research Design; Reticuloendothelial System, Serum, Plasma; Risk; Se element; Selenium; Selenomethionine; Serum, Plasma; Severities; Staging; Study Type; Supplementation; Susceptibility; Toxic effect; Toxicities; Undernutrition; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Work; Yeasts; assay development; base; bioavailability of drug; biomarker; children; cost; dietary deficiency; disease/disorder; drug/agent; expectation; glutathione peroxidase; hepatopathy; indexing; liver disorder; nutrient requirement; pilot study; repair; repaired; selenium deficiency; selenoenzyme; selenoprotein; small molecule; study design; sugar; youngster",Human Se Nutritional Requirement and Biomarkers in Health and Disease,,58763,INMP,Integrative Nutrition and Metabolic Processes Study Section,,10,349444,
7760631,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK059578-07,,NIDDK:360876;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"WILLIAMS, JOHN A;",1869147;,5R01DK059578,04/01/2001,11/30/2013,"21+ years old; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Acinar Cell; Aciner Cells; Acinus organ component; Activator Protein-1; Acute; Address; Adenoviral Vector; Adenovirus Vector; Adherent Culture; Adult; Antiproteases; Attention; Blood Coagulation Factor IV; Blood Plasma; Body Tissues; CCK; CCND1 Protein; Ca++ element; Caerulein; Calcineurin; Calcium; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Lineage; Cell division; Cells; Ceruletid; Ceruletide; Chemotherapy-Hormones/Steroids; Cholecystokinin; Chronic; Coagulation Factor IV; Collagen; Cyclin D1; Diet; EC 2.7.2-; ERG gene; ERK MAP Kinases; Endocrine Gland Secretion; Endopeptidase Inhibitors; Enhancer-Binding Protein AP1; Ensure; Enzymes; Ethionine; Exocrine pancreas; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FOS gene; FRAP1 protein, human; Factor IV; Family member; Feedback; G0S7; G1/S-Specific Cyclin D1; GFAC; Gastrointestinal Tract, Pancreas; Gene Expression; Gene Proteins; Gene Targeting; Generalized Growth; Genes; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hormonal; Hormones; Human; Human, Adult; Human, General; In Vitro; Individual; Injury; JNK; JNK1; JNK1A2; JNK21B1/2; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Knowledge; L-Homocysteine, S-ethyl-; Lead; MAP Kinase 8 Gene; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MAPK8; MAPK8 gene; MEKs; Malignant Pancreatic Neoplasm; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mitogenesis; Modeling; Monolayer culture; Murine; Mus; N,N-dimethylcarbamoylmethyl-4-(4-guanidinobenzoyloxy)phenylacetate methanesulfonate; Natural regeneration; PP2B; PRAD1 Protein; PRKM8; Pancreas; Pancreas Cancer; Pancreatic; Pancreatic Cancer; Pancreatic Diseases; Pancreatic Disorder; Pancreatitis; Pancreozymin; Pathway interactions; Pattern; Pb element; Peptidase Inhibitors; Peptide Hydrolase Inhibitors; Peptide Peptidohydrolase Inhibitors; Phosphates; Plasma; Positive Control of Cell Proliferation; Protease Antagonists; Protease Inhibitor; Protein Gene Products; Protein Phosphatase-2B; Proteinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-1; Protooncogene FOS; RAFT1 protein, human; RAPT1 protein, human; RNA, Small Interfering; Rapamycin Target Protein; Regeneration; Regulation; Regulatory Pathway; Reticuloendothelial System, Serum, Plasma; Role; SAPK1; Serum, Plasma; Signal Pathway; Small Interfering RNA; Stimulation of Cell Proliferation; Targetings, Gene; Techniques; Therapeutic Hormone; Threonine/Tyrosine Protein Kinase; Tissue Growth; Tissues; Transcription Factor AP-1; Transgenic Mice; Uropancreozymin; Work; acinus; adeno vector; adenovector; adult human (21+); bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; c fos; c jun; c-bcl-1 Proteins; c-fos Gene; c-fos Proto-Oncogenes; c-jun Gene; camostat; camostate; chronic pancreatitis; cyclin D; design; designing; early response gene; extracellular; extracellular signal related kinase; feeding; gene product; heavy metal Pb; heavy metal lead; human FRAP1 protein; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; inorganic phosphate; loss of function; mTOR; ontogeny; pancreas disorder; pathway; protein expression; public health relevance; rapamycin and FKBP12 target 1 protein, human; recurrent pancreatitis; regenerate; response; siRNA; social role; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Dietary Regulation of Pancreatic Digestive Enzymes, NARRATIVE A number of pancreatic diseases including acute and chronic pancreatitis and pancreatic cancer lead to a loss of functioning pancreatic tissue. Knowledge from this project should allow designing approaches to assist the human pancreas to regenerate and ensure an adequate supply of pancreatic digestive enzymes.,59578,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,7,360876,
7759189,R01,DK,5,,02/01/2010,01/31/2011,PA-05-001,5R01DK059893-09,,NIDDK:293834;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,COLUMBIA,UNITED STATES,NUTRITION,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"PETRIS, MICHAEL J;",6716695;,5R01DK059893,07/01/2001,01/31/2012,"ATP Synthesis; ATP Synthesis Pathway; ATP phosphohydrolase; ATP7A protein; ATP7A protein, human; ATPase; ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome), human; Achievement; Achievement Attainment; Adenosine Triphosphatase; Adenosinetriphosphatase; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Autoregulation; Biology; Blood Vessels; Cancers; Cardiovascular Diseases; Cell membrane; Connective Tissue; Copper; Cu element; Cytoplasm; Cytoplasmic Membrane; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Enzymes; Fe element; Generalized Growth; Goals; Golgi; Golgi Apparatus; Golgi Complex; Growth; Homeostasis; Hypocupremia, Congenital; Hypocupremias, Congenital; INFLM; Inflammation; Inflammatory; Iron; Kinky Hair Disease; Kinky Hair Syndrome; MNK protein, human; Malignant Neoplasms; Malignant Tumor; Mc1 protein, human; Mediating; Menkes Kinky Hair Syndrome; Menkes Syndrome; Menkes disease; Menkes disease Cu-binding P-type ATPase; Menkes kinky hair syndrome (MKHS); Menkes protein, human; Menkes' Disease; Nerve Impulse Transmission; Nerve Transmission; Neuronal Transmission; Nutrient; O element; O2 element; Oxygen; Pathology; Pathway interactions; Physiological Homeostasis; Pigmentation; Pigmentation physiologic function; Plasma Membrane; Primary Senile Degenerative Dementia; Process; Protein Trafficking; Proteins; Regulation; Role; Steely Hair Disease; Steely Hair Syndrome; TGN; Tissue Growth; Traffickings, Protein; VESCL; Vesicle; X-linked copper malabsorption; anti-microbial; antimicrobial; cardiovascular disorder; congenital hypocupraemia syndrome; copper deficiency; copper transport disease; dementia of the Alzheimer type; disease/disorder; gene product; hypocupremia; kinky hair syndrome (KHS); macrophage; malignancy; meetings; neoplasm/cancer; neurotransmission; ontogeny; pathway; plasmalemma; primary degenerative dementia; protein transport; response; senile dementia of the Alzheimer type; sex-linked neurodegenerative disease with monilethrix; social role; trafficking; trans-Golgi Network; trichopoliodystrophy; vascular",Regulation of copper homeostasis by the MNK protein,,59893,INMP,Integrative Nutrition and Metabolic Processes Study Section,,9,293834,
7768382,R01,DK,5,,03/01/2010,02/28/2011,PA-07-070,5R01DK060533-08,,NIDDK:321226;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"HEBROK, MATTHIAS ;",6800120;,5R01DK060533,12/01/2001,02/28/2013,"21+ years old; Address; Adult; Animal Welfare; B9 endocrine pancreas; Bibliography; Cell Communication and Signaling; Cell Culture Techniques; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cilia; Code; Coding System; Complex; Country; Data; Development; Duct; Duct (organ) structure; ES cell; Ecological impact; Embryo Development; Embryogenesis; Embryonic Development; Endocrine; Environment; Environmental Impact; Epithelial; Epithelial Cells; Epithelium; Equipment; Erinaceidae; Ethics Committees, Research; GLI-Kruppel Family Member 2; GLI2; GLI2 gene; Gastrointestinal Tract, Pancreas; Gene Targeting; Genes; Gx Protein; Hedgehog (Hh) signal transduction pathway; Hedgehogs; Human, Adult; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Mesenchymal; Mice, Transgenic; Names; Nature; Nesidioblasts; Organ; Organogenesis; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resources; Role; SMO; SMO protein, human; SMOH; SMOH protein, human; Signal Transduction; Signal Transduction Systems; Signaling; Smoothened; Smoothened Homolog; Staging; THP; Targetings, Gene; Time; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transgenic Mice; Vertebrate Animals; Vertebrates; abstracting; adult human (21+); appendage; beta cell development; biological signal transduction; cell type; design; designing; embryonic stem cell; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; expiration; hedgehog signaling pathway; hh signaling pathway; human SMO protein; human subject; islet development; islet progenitor; novel; pathway; programs; research study; smoothened homolog (Drosophila), human; smoothened signaling pathway; social role; stem cell of embryonic origin; vertebrata",Effects of Hedgehog Signaling on Pancreas Organogenesis,,60533,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,8,321226,
7761771,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK060540-09,,NIDDK:312930;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"VAISSE, CHRISTIAN ;",6799337;,5R01DK060540,02/15/2002,11/30/2010,"0-11 years old; 21+ years old; Adult; Autoregulation; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Central Nervous System; Characteristics; Child; Child Youth; Children (0-21); Code; Coding System; Coupled; DNA Alteration; DNA mutation; Defect; Disease; Disorder; Effectiveness; Food Intake Regulation; Funding; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Alteration; Gene Mutation; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetic defect; Genetic mutation; Genotype; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Homeostasis; Human; Human, Adult; Human, Child; Human, General; Individual; Inherited Predisposition; Inherited Susceptibility; Investigators; Lead; Link; MC4 Receptor; Man (Taxonomy); Man, Modern; Melanocortin 4 Receptor; Melanocortin 4 receptor mutation; Molecular; Morbid Obesity; Mutation; N-terminal; NH2-terminal; Nervous System, CNS; Neuraxis; Obesity; Obesity, Morbid; Outcome; Patients; Pb element; Phenotype; Physiological Homeostasis; Population; Predisposition; Prevalence Study; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Receptor Activation; Receptor, Melanocortin, Type 4; Reporting; Research Personnel; Researchers; Role; Sequence Alteration; Severe obesity; Study, Prevalence; Susceptibility; Testing; Variant; Variation; Variation (Genetics); adiposity; adult human (21+); allelic variant; bariatric surgery; children; cohort; corpulence; corpulency; corpulentia; disease/disorder; effective therapy; experiment; experimental research; experimental study; gastric banding; gastric bypass surgery; genetic etiology; genetic mechanism of disease; genetic promoter element; genetic vulnerability; genome mutation; heavy metal Pb; heavy metal lead; implantable gastric stimulation banding; mutation carrier; novel; obese; obese people; obese person; obese population; obesity surgery; obesity treatment; obesity, extreme; research study; social role; stomach stapling; weight loss surgery; youngster",The Melanocortin-4 Receptor in Human Obesity,,60540,ZRG1,Special Emphasis Panel,,9,312930,
7758776,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK061297-07,,NIDDK:413651;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DAVIS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"DANDEKAR, SATYA ;",1905791;,5R01DK061297,10/01/2001,12/31/2012,"AIDS; AIDS Virus; ATGN; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affect; Analysis, Data; Antigens; Antiretroviral Therapy, Highly Active; Apoptosis; Apoptosis Pathway; Assay; Base Sequence; Bioassay; Biologic Assays; Biological Assay; Biopsy; Blood Plasma; Blood Sample; Blood monocyte; Blood specimen; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CTLA-8; CTLA8; Cell Death; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Lineage; Cell Maturation; Cell/Tissue, Immunohistochemistry; Cells; Cells, CD4; Characteristics; Chronic; Cytofluorometry, Flow; Cytokines and Inflammatory Response; Cytokines, Chemotactic; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Data Analyses; Defect; Development; Disease; Disorder; Electron Microscopy; Electrons; Enrollment; Enzymes; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Equilibrium; Event; Evolution; Expression Profiling; Expression Signature; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; GALT; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genome; Genomics; Gut Epithelium; Gut associated lymphoid tissue; HAART; HIV; HIV-1; HIV-I; HIV1; HTLV-III; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Highly Active Antiretroviral Therapy; Histopathology; Homologous Chemotactic Cytokines; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; IHC; IL-17; IL-17A; IL-23; IL17; IL17 Protein; IL17A; IMPHENO; INFLM; Immune; Immune Function, Cellular; Immune response; Immune system; Immunodeficiency Virus Type 1, Human; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic Deficiency Syndrome, Acquired; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunophenotyping; Impairment; Individual; Inducer Cells; Infection; Inflammation; Inflammatory; Inflammatory Response Pathway; Intercrines; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin-17; Intestinal; Intestines; Investigation; Knowledge; LAV-HTLV-III; Link; Longitudinal Studies; Lymphadenopathy-Associated Virus; Lymphatic Tissue; Lymphocyte; Lymphocytic; Lymphoid Tissue; MTGN; Marrow monocyte; Measures; Mediating; Microfluorometry, Flow; Microscopic; Mitogens; Modeling; Molecular; Molecular Fingerprinting; Molecular Profiling; Molecular Virology; Mucosa; Mucosal Immune Responses; Mucosal Tissue; Mucous Membrane; Natural regeneration; Negative Beta Particle; Negatrons; Nucleotide Sequence; Occluding Junctions; Outcome; Pathologic; Pathway interactions; Patient Care; Patient Care Delivery; Patients; Plasma; Predisposition; Prevalence; Proliferation Marker; Proteins; RT-PCR; RTPCR; Regeneration; Reporting; Residual; Residual state; Reticuloendothelial System, Serum, Plasma; Reverse Transcriptase Polymerase Chain Reaction; Role; SIS cytokines; Sampling; Serum, Plasma; Site; Staging; Structure; Structure of intestinal epithelium; Subtyping, Immunologic; Subtypings, Immunologic; Susceptibility; T-Cell Depletion; T-Cell Subsets; T-Cells; T-Cells, Helper-Inducer; T-Lymphocyte; T-Lymphocyte Subsets; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Th-1 Cell; Th1 Cells; Thymus-Dependent Lymphocytes; Tight Junctions; Time; Tissues; Trefoil; Type 1 Helper Cell; Variant; Variation; Villus; Viral; Viral Burden; Viral Diseases; Viral Load; Viral Load result; Virus Diseases; Virus-HIV; Zonula Occludens; anti-retroviral therapy, highly active; antimicrobial peptide; balance; balance function; body system, allergic/immunologic; bowel; cell type; chemoattractant cytokine; chemokine; cohort; cytokine; disease/disorder; enroll; experience; flow cytophotometry; gastrointestinal epithelium; gene product; helper T cell; host response; human T cell leukemia virus III; human T lymphotropic virus III; immune function; immunogen; immunophenotype; immunoresponse; improved; in vivo; insight; interleukin-23; intestinal epithelium; laser capture microdissection; long-term study; lymph cell; macrophage; memory CD4 T cell; memory CD4 T lymphocyte; microbial; molecuar profile; molecular signature; monocyte; necrocytosis; novel; nucleic acid sequence; organ system, allergic/immunologic; pathogen; pathway; peripheral blood; public health relevance; receptor expression; regenerate; response; restoration; reverse transcriptase PCR; social role; success; therapeutic vaccine; thymus derived lymphocyte; viral infection; virus infection",HIV reservoir and CD4 repopulation in gut lymphoid tissue," Project Narrative Despite therapy, human immunodeficiency virus (HIV) is not completely eliminated from the body. We will examine the role of intestinal tissue in the persistence of HIV infection. Since the intestinal tissues contain most of the body's immune cells, persistent HIV infection leads to severe impairment of both digestive and immune function and may increase the rate of progression to AIDS.",61297,AMCB,AIDS Molecular and Cellular Biology Study Section,,7,413651,
7760877,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK061933-08,,NIDDK:301450;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AURORA,UNITED STATES,PHARMACOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"BAIN, DAVID L;",1933618;,5R01DK061933,03/15/2003,01/31/2012,"ATF; Animal Welfare; Architecture; Bibliography; Binding; Binding (Molecular Function); Biological Models; Clinical; Country; Coupled; DNA Binding; DNA Binding Interaction; Ecological impact; Engineering / Architecture; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Goals; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Isoforms; Laboratory Study; Ligands; Man (Taxonomy); Man, Modern; Model System; Models, Biologic; Molecular; Molecular Interaction; Names; Nuclear Receptors; Outcome; Physiologic; Physiological; Principal Investigator; Progesterone Receptors; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Receptor Protein; Receptors, Progesterone; Receptors, Progestin; Research; Research Ethics Committees; Research Resources; Resources; Transcription Activation; Transcriptional Activation; Up-Regulation; Vertebrate Animals; Vertebrates; abstracting; activating transcription factor; expiration; human subject; member; progesterone receptor; progesterone receptor A; progesterone receptor B; programs; receptor; receptor binding; receptor function; vertebrata",Mechanistic Studies of Progesterone Receptor Function,,61933,MSFB,Macromolecular Structure and Function B Study Section,,8,301450,
7755806,R01,DK,5,,02/01/2010,01/31/2011,PAS-07-267,5R01DK062027-07,,NIDDK:343097;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"HAMMER, GARY D;",1892284;,5R01DK062027,07/01/2002,01/31/2013,"ACTH; ACTH (1-39); AD4BP protein; ADRGND; Activities of Daily Living; Activities of everyday life; Ad4-binding protein; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Disorder; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Anaplastic; CAPS; Cancers; Capsules; Cell Cycle; Cell Division Cycle; Cells; Cellular biology; Chemotherapy-Hormones/Steroids; Cortex of adrenal gland; Corticotropin; Corticotropin (1-39); Data; Disease; Disorder; Endocrine Gland Secretion; FTZF1 protein; Fushi tarazu factor homolog 1; Future; Gene Targeting; Generalized Growth; Genes; Genomics; Growth; Hormones; Laboratories; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Molecular; Mother Cells; NR5A1 protein; Organ failure; Pathway interactions; Population; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proliferating; Property; Property, LOINC Axis 2; Regulation; Role; SF 1; SF-1 transcription factor; SF1; Signal Pathway; Stem cells; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic; Therapeutic Hormone; Tissue Growth; Undifferentiated; adrenal 4 binding protein; adrenal disorder; base; capsule (pharmacologic); cell biology; daily living functionality; disease/disorder; functional ability; functional capacity; in vivo; malignancy; mouse model; neoplasm/cancer; novel; nuclear receptor 5A1 protein; ontogeny; pathway; programs; public health relevance; response; self-renewal; social role; stem; stem cell niche; steroid hormone receptor Ad4BP; steroidogenic factor 1; suprarenal gland; transcription factor; transcription factor sf1",Mechanisms of Adrenal Differentiation," NARRATIVE Most hormone disorders of the adrenal cortical occur in the context of organ failure or overgrowth. Increasing evidence indicates that the cortex constantly renews its cell population through the constant proliferation of uncommitted cells lying in and/or underneath the outer capsule. Using cellular systems, mouse models together with genomic approaches, we aim to characterize the stem/progenitor cells of the adrenal cortex and uncover the mechanisms by which these cells are regulated by SF1 in normal adrenal growth maintenance. Future efforts are predicted to focus on therapies that target this pathway and downstream genes that are found in the course of these studies to participate in adrenocortical stem/progenitor cell biology.",62027,MCE,Molecular and Cellular Endocrinology Study Section,,7,343097,
7749557,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK062028-07,,NIDDK:362780;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHARLESTON,UNITED STATES,PHARMACOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"SCHNELLMANN, RICK G;",1898989;,5R01DK062028,03/15/2002,11/30/2010,"1-Alkyl-2-acetyl-sn-glycerophosphocholine; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one; 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one; 6-BTNPO; 85kDa Calcium-Independent Phospholipase A2; AGEPC; Active Oxygen; Acute Kidney Failure; Arachidonic Acids; BEL cpd; Base Sequence; Binding; Binding (Molecular Function); Body Tissues; Brain; C-terminal; CaI-PLA(2); CaI-PLA2; Calcium-Independent Cytosolic Phospholipase A2; Calcium-Independent Cytosolic Phospholipase A2 Group IVC; Calcium-Independent Cytosolic Phospholipase A2 Group VI; Calcium-Independent Cytosolic Phospholipase A2 IVC; Calcium-Independent Cytosolic Phospholipase A2VI; Calcium-Independent Phospholipase A2; Cell Death; Cells; Cellular injury; Classification; Codon, Initiation; Codon, Initiator; Codon, Start; Common Rat Strains; Cytosolic Phospholipase A2; Cytosolic Phospholipase A2 Gamma; Cytosolic Phospholipase A2 Group IV; Cytosolic Phospholipase A2 IVC; Cytosolic Phospholipase A2G4; Cytosolic Phospholipase A2G4C; Cytosolic Phospholipase A2G6; Cytosolic Phospholipase A2IV; Drugs; EC 3.1.1.4; Encephalon; Encephalons; Endoplasmic Reticulum; Enzymes; Ergastoplasm; Exhibits; FLR; Failure (biologic function); Family; Fatty Acids; Fatty Acids, Nonesterified; Free Fatty Acids; GVI PLA2; Genes; HELSS; Heart; Heart Mitochondria; Hydrolysis; IPLA2; Initiator Codon; Ischemia; Isoforms; Kidney; Kidney Failure, Acute; Kidney Insufficiency, Acute; Knowledge; Lead; Lecithinase A2; Leukotrienes; Lipid Peroxidation; Liver; Location; Lysophosphatidic Acids; Lysophospholipids; MAFP cpd; Mammals, Rabbits; Mammals, Rats; Me-arachidonyl-FPO2; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Membrane; Mitochondria; Mitochondria, Heart; Modeling; Molecular Interaction; Molecular Weight; Myocardial Mitochondria; Necrosis; Necrotic; Nervous System, Brain; Nonesterified Fatty Acids; Nucleotide Sequence; Nucleotides; Organ; Organ Survival; Oryctolagus cuniculus; Oxidants; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; PAF; PAF-Acether; PLA(2)-IV; PLA2; PLA2-IV; PLA2G4C; PLA2G4C protein, human; PLA2G6; PLA2G6 gene; PLA2G6 protein, human; PLIalpha; Pathologic; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatides; Phospholipase A2; Phospholipase A2 Group IVC; Phospholipase A2 Group VI; Phospholipase A2G4; Phospholipase A2IV; Phospholipase A2IVC; Phospholipase A2VI; Phospholipids; Phosphorylcholine, Acetyl Glyceryl Ether; Physiologic; Physiological; Platelet Activating Factor; Platelet-Activating Substance; Position; Positioning Attribute; Pro-Oxidants; Progress Reports; Prostaglandins; Prostanoids; Protein Isoforms; Proteins; Rabbit, Domestic; Rabbits; Rat; Rattus; Reactive Oxygen Species; Renal Cell; Renal Failure, Acute; Renal Insufficiency, Acute; Reperfusion Therapy; Reports, Progress; Source; Survival, Organ; Systematics; Thromboxanes; Tissues; Translation Initiation; Urinary System, Kidney; base; body system, hepatic; bromoenol lactone; cPLA2; cPLA2-Gamma; cell damage; cell injury; drug/agent; electron acceptor; failure; gene product; group VI phospholipase A(2); heavy metal Pb; heavy metal lead; human PLA2G4C protein; human PLA2G6 protein; iPLA(2); iPLA(2)-1; iPLA2 enzyme; in vivo Model; kidney cell; knock-down; lecithinase A; member; membrane structure; methyl arachidonyl fluorophosphonate; methyl arachidonylfluorophosphonate; methylarachidonoylfluorophosphonate; mitochondrial; mitochondrial membrane; necrocytosis; new therapeutics; next generation therapeutics; novel; novel therapeutics; nucleic acid sequence; organ system, hepatic; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; phospholipase A2 IV; phospholipase A2 inhibitor; phospholipase A2-gamma; phosphonofluoridic acid methyl-5,8,11,14-eicosatetraenyl ester; prevent; preventing; receptor binding; renal; repair; repair endonuclease; repair enzyme; repaired; reperfusion; response; toxicant",Novel Phospholipase A2 in Oxidant-Induced Cell Injury,,62028,SAT,"Surgery, Anesthesiology and Trauma Study Section",,7,362780,
7759568,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK062277-07,,NIDDK:445101;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,PATHOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"MONGA, SATDARSHAN SINGH;",6958447;,5R01DK062277,07/01/2002,12/31/2013,"21+ years old; Activins; Address; Adult; Albumins; Alcohols; Alleles; Allelomorphs; Antibodies; Apoptosis; Apoptosis Antigen Ligand 1; Apoptosis Pathway; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bile Ducts; Bile duct structure; Biliary; Binding; Binding (Molecular Function); Biology; Brachydanio rerio; CBP protein; CBP protein, human (CREB binding protein); CCND1 Protein; CD178 Antigen; CD95 Ligand; CD95 antigen ligand; CREB Binding Protein; CREB binding protein, human; CREB-binding protein; CREBBP protein, human; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancers; Catenin, Beta-1; Cell Communication and Signaling; Cell Death, Programmed; Cell Nucleus; Cell Polarity; Cell Signaling; Cessation of life; Chemical Class, Alcohol; Cyclin D1; Danio rerio; Data; Death; Development; Differentiation Factor, B-Cell; Disease; Disorder; EP300; EP300 gene; Embryo; Embryonic; Ensure; Equilibrium; Event; FLR; FSH-Releasing Protein; Failure (biologic function); Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Forecast of outcome; Funding; G1/S-Specific Cyclin D1; GFAC; Gene Expression; Generalized Growth; Genes; Germ Lines; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Growth and Development; Growth and Development function; HB-GAM receptor; HPGF; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Failure; Hepatic Parenchymal Cell; Hepatitis; Hepatocyte; Hepatocyte-Stimulating Factor; Histology; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; Individual; Injury; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Investigation; Knockout Mice; LEF Transcription Factor; LPS; Light; Lipopolysaccharides; Liver; Liver Cells; Liver Failure; Liver Regeneration; Liver Stem Cell; Liver diseases; Lymphoid Enhancer Factor; MGI-2; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Morphogenesis; Mother Cells; Murine; Mus; Myeloid Differentiation-Inducing Protein; N-syndecan; Natural regeneration; Nuclear; Nuclear Translocation; Nucleus; Null Mouse; Organogenesis; PRAD1 Protein; PRO2286; Partial Hepatectomy; Pathway interactions; Phospho-CREB Binding Protein; Photoradiation; Plasmacytoma Growth Factor; Play; Process; Progenitor Cells; Prognosis; Proteins; Proto-Oncogene Proteins c-bcl-1; Regeneration; Regulation; Reporting; Resistance; Role; Rubinstein-Taybi syndrome protein, human; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Staging; Stem cells; T Cell Factor; TCF Transcription Factor; TCF-4; TCF4; TCF7L2; TCF7L2 gene; Testing; Tissue Growth; Toxin; Trans-Activation (Genetics); Transactivation; Transcription Activation; Transcriptional Activation; Tumor Necrosis Factor Ligand Superfamily Member 6; Up-Regulation; Xenopus; Zebra Danio; Zebra Fish; Zebrafish; adult human (21+); balance; balance function; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; beta catenin; bile duct; bile ductule; biological signal transduction; body system, hepatic; c-bcl-1 Proteins; cellular polarity; cofactor; cyclin D; decorin; disease/disorder; failure; gene product; heparin-binding growth associated molecule receptor; hepatic cell proliferation; hepatic cellular proliferation; hepatocyte cell proliferation; hepatocyte cellular proliferation; hepatocyte proliferation; hepatopathy; human CREBBP protein; improved; in vivo; interferon beta 2; jagged-1; jagged1 protein; liver cell proliferation; liver cellular proliferation; liver disorder; mRNA Expression; male; malignancy; neoplasm/cancer; nuclear protein CBP; ontogeny; organ system, hepatic; outcome forecast; oval cell; p300; partial excision of liver; pathway; phospho-CREB-binding protein; public health relevance; regenerate; resistant; response; social role; subtotal hepatectomy; syndecan 3",Role of Wnt/Beta-Catenin Signaling in Liver Development," NARRATIVE: Understanding signaling pathways dictating the processes of liver growth, regeneration & development would be critical to identify the molecular basis of many hepatic diseases ranging from developmental anomalies to cancers & hepatic failure due to hepatitis, alcohol & other toxins. Our proposal will comprehensively examine Wnt signaling in liver biology to eventually improve prognosis of liver diseases.",62277,HBPP,Hepatobiliary Pathophysiology Study Section,,7,445101,
7743404,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK063934-08,,NIDDK:317666;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,INDIANAPOLIS,UNITED STATES,GENETICS,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"WHITE, KENNETH E;",1906908;,5R01DK063934,12/27/2002,11/30/2011,"Address; Alleles; Allelomorphs; Animal Welfare; Autoregulation; Bibliography; Biological; Biology; Bone Diseases, Metabolic; Breeding; Calcification, Pathologic; Calcinosis; Causality; Country; Data; Disease; Disorder; Distal; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Etiology; FGF23 gene product; Familial hypophosphatemic bone disease; Fracture; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; Homeostasis; Human; Human, General; Hypophosphatemia; IACUC; IRBs; Image; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Investigation; Isoforms; Kidney; Kidney Tubules, Proximal; Knock-in; Knock-in Mouse; Knockout Mice; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metabolic Bone Diseases; Metabolic Processes; Metabolic disorder of bone; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Minerals; Modeling; Molecular; Murine; Mus; Mutate; Mutation; Names; Null Mouse; Osteomalacia; Pathogenesis; Phenotype; Phosphates; Physiological Homeostasis; Physiology; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Isoforms; Proximal Kidney Tubules; Receptor Protein; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Rickets; Rickets, Hypophosphatemic; Rickets, Vitamin D-Resistant; Role; Secondary to; Syndrome; System; System, LOINC Axis 4; Testing; Urinary System, Kidney; VIT D; Vertebrate Animals; Vertebrates; Vitamin D; Work; X linked hypophosphatemia in rickets; X-Linked Hypophosphatemic Rickets; abstracting; base; bone cell; bone fracture; bone metabolism disorder; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; expiration; familial hypophosphatemia in rickets; fibroblast growth factor 23; gene function; genome mutation; human subject; hypophosphatemia in rickets; imaging; in vivo; inorganic phosphate; insight; loss of function mutation; metabolic bone disease; novel; positional cloning; programs; receptor; renal; renal proximal tubule; reverse genetics; skeletal; social role; vertebrata; wasting",FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS,,63934,SBDD,Skeletal Biology Development and Disease Study Section,,8,317666,
7806379,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK064344-07,,NIDDK:308013;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"SCALIA, ROSARIO G;",6805711;,5R01DK064344,04/01/2003,01/31/2012,"ANG-(1-8)Octapeptide; Adhesion Molecule; Affect; American Heart Association; AngII; Angiotensin AT1 Receptor; Angiotensin II; Angiotensin II Receptor; Angiotensin II Type 1 Receptor; Angiotensin-(1-8) Octapeptide; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Sense DNA; Antiinflammatories; Antiinflammatory Agents; Antisense DNA; Applications Grants; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Biochemistry; Biologic Marker; Biological Markers; Blood Coagulation Factor IV; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Pressure; Blood Segmented Neutrophil; Blood Vessels; Blood leukocyte; Blotting, Western; Body Tissues; CD106; CD106 Antigens; CD54 (ICAM 1); CD54 Antigens; CD62E Antigens; Ca++ element; Ca2+-Activated Protease; Calcium; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Adhesion Molecule E-Selectin; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Chemistry, Biological; Coagulation Factor IV; Common Rat Strains; DNA, Antisense; Data; Desminase; Development; Diabetic Angiopathies; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Disease; Disorder; Dose; Drugs; Dysfunction; E-Selectin; EC 2.7; ELAM-1; Electrodes; Electrophoretic Mobility Shift Assay; Endogenous Nitrate Vasodilator; Endothelial Adhesion Molecule 1; Endothelial Cells; Endothelial Leukocyte Adhesion Molecule-1; Endothelium; Endothelium, Vascular; Endothelium-Derived Relaxing Factor; Esteroproteases; Expectancy; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Factor IV; Functional disorder; Funding; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Goals; Grant Proposals; Grants, Applications; Health; Heterophil Granulocyte; Human; Human, General; Hyperglycemia; ICAM-1; IHC; INCAM-110; IVM; Immunofluorescence; Immunofluorescence Immunologic; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Immunofluorescence; In Vitro; Incidence; Indirect Costs; Inducible Cell Adhesion Molecule 110; Inflammatory; Injury; Insulin Resistance; Intercellular adhesion molecule 1; Intracellular Communication and Signaling; Kinases; Knockout Mice; Knowledge; LECAM-2; Laboratories; Laboratory Study; Leukocyte Endothelial Cell Adhesion Molecule 2; Leukocytes; Link; Literature; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Measurement; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic syndrome; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microscopy; Moab, Clinical Treatment; Mobility Shift Assay; Molecular; Molecular Interaction; Molecular Marker; Molecular Target; Monoclonal Antibodies; Mononitrogen Monoxide; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Null Mouse; Obesity; Obesity associated cardiovascular disease; Obesity related cardiovascular disease; Organ; Organ System, Cardiovascular; Papain-Like Cysteine Protease; Peptidases; Peptide Hydrolases; Peroxidases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Physiology; Physiopathology; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Process; Proteases; Proteinases; Proteolytic Enzymes; QOL; Quality of life; RT-PCR; RTPCR; Rat; Rattus; Receptor Protein; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Research; Reticuloendothelial System, Leukocytes; Reverse Transcriptase Polymerase Chain Reaction; Rodent; Rodentia; Rodentias; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signature Molecule; Superoxide Anion; Superoxide Radical; Superoxides; System; System, LOINC Axis 4; Techniques; Technology; Therapeutic; Therapeutic Intervention; Tissues; Transphosphorylases; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; VCAM; VCAM-1; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vascular Endothelium; Vascular, Heart; Western Blotting; Western Blottings; Western Immunoblotting; White Blood Cells; White Cell; Work; adiposity; atheromatosis; atherosclerotic vascular disease; biological signal transduction; biomarker; blood vessel disorder; cardiovascular disorder; cell adhesion protein; circulatory system; corpulence; corpulency; corpulentia; cost; design; designing; disease/disorder; drug/agent; economic cost; economic implication; endothelial cell derived relaxing factor; endothelial leukocyte adhesion molecule; fighting; gel shift assay; hyperglycemic; improved; in vivo; inhibitor; inhibitor/antagonist; insulin resistant; intervention therapy; intravital microscopy; leukocyte activation; microvascular complications; microvascular complications of diabetes; microvascular disease; model organism; neutrophil; new therapeutics; next generation therapeutics; novel; novel therapeutics; obese; obese people; obese person; obese population; pandemic; pandemic disease; pathophysiology; prevent; preventing; protein blotting; receptor; response; reverse transcriptase PCR; social; social role; stem; tool; vascular; vascular inflammation; white blood cell; white blood corpuscle",In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance,,64344,VCMB,Vascular Cell and Molecular Biology Study Section,,7,308013,
7764755,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK064572-08,,NIDDK:294941;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,PEDIATRICS,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"HRUZ, PAUL W;",3128377;,5R01DK064572,04/01/2003,01/31/2011,"1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine; 2',3'-Didehydro-2',3'-dideoxythmidine; 2',3'-Didehydro-3'-deoxythymidine; 2'3' didehydrodeoxythymidine; 2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; 3'-Azido-2',3'-Dideoxythymidine; 3'-Azido-3'-deoxythymidine; 3'-Deoxy-2'-thymidinene; 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-2,5,6,10,13-pentaazatetradecanedioic acid dimethyl ester; ACRP30 protein; AZT; AZT (Antiviral); Acute; Adipocytes; Adipose Cell; Adipose tissue; Animals; Antibodies; Antibody Affinity; Antigenic Determinants; Antiretroviral Therapy, Highly Active; Atazanavir; Azidothymidine; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Binding Sites; Blood Serum; Blotting, Western; Body Tissues; Cardiac; Chronic; Clamping, Glucose; Co-Immunoprecipitations; Combining Site; Common Rat Strains; Continuous Intravenous Infusion; Control Animal; Coupled; D-arabino-Hexose, 2-deoxy-; D4T; Deoxyglucose; Development; Diabetes Mellitus; Didehydrodeoxythymidine; Drugs; Epitopes; Euglycaemic Clamp; Euglycemic Clamping; Fat Cells; Fats; Fatty Acids, Nonesterified; Fatty Tissue; Fatty acid glycerol esters; Free Fatty Acids; Funding; GLUT; GLUT 4 protein; GLUT1; GLUT4; GLUT4 gene; GLUT4 protein; GTR1; Gene Products, RNA; Genetic Alteration; Genetic Change; Genetic defect; Glucose Binding Protein; Glucose Clamp; Glucose Transporter; Glucose Transporter Type 1 Gene; Goals; HAART; HIV Protease Inhibitors; Heart; Hepatic; Highly Active Antiretroviral Therapy; Humulin R; IDV; Indinavir; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Knockout Mice; Label; Leptin; Ligand Binding Protein; Lipocytes; Mammals, Rats; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Measures; Mediating; Medication; Metabolic; Metabolic syndrome; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Molecular; Molecular Interaction; Molecular Target; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Mutation; Nonesterified Fatty Acids; Novolin R; Nucleosides; Null Mouse; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Patients; Peptides; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Photometry/Spectrum Analysis, Mass; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Production; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA; RNA, Non-Polyadenylated; RTV; Radiolabeled; Rat; Rattus; Reactive Site; Retinoid Binding Proteins; Retinol Binding Proteins; Retinol-Binding Protein 1; Reverse Transcriptase Inhibitors; Reyataz; Ribonucleic Acid; Ritonavir; Role; SLC2A1; SLC2A1 gene; Serum; Skeletal Muscle Tissue; Skeletal muscle structure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stavudine; System; System, LOINC Axis 4; Thymidine, 2',3'-didehydro-3'-deoxy-; Thymidine, 3'-azido-3'-deoxy-; Time; Tissues; Toxic effect; Toxicities; Transgenic Mice; Transgenic Organisms; Transport Protein, Glucose; Western Blotting; Western Blottings; Western Immunoblotting; Work; Xenopus oocyte; ZDV; Ziagen; Zidovudine; abacavir; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adipose; anti-retroviral therapy, highly active; antigen antibody affinity; apM-1 protein; apM1 (adipose-specific) protein; azidodeoxythymidine; basal insulin; blood glucose regulation; diabetes; drug/agent; experiment; experimental research; experimental study; functional loss; gene product; genome mutation; glucose RA; glucose control; glucose disposal; glucose homeostasis; glucose production; glucose rate of appearance; glucose regulation; glucose transport; glucose uptake; insulin resistant; insulin stimulated glucose disposal; insulin-responsive glucose transporter; intraperitoneal; mitochondrial; norvir; ob/ob mouse; prevent; preventing; protein blotting; radiolabel; radiotracer; research study; resistin; social role; transgenic; uptake; white adipose tissue; yellow adipose tissue; zerit",Mechanisms for Altered Glucose Homeostasis During HAART,,64572,ACE,AIDS Clinical Studies and Epidemiology Study Section,,8,294941,
7758320,R01,DK,5,,02/01/2010,01/31/2011,PA-07-056,5R01DK064973-06,,NIDDK:370656;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"PRINCE, VICTORIA E;",3131553;,5R01DK064973,07/05/2003,01/31/2014,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; ATRA; Address; Affect; All-trans retinoic acid; Anaplastic; B9 endocrine pancreas; Biological Models; Body Tissues; Brachydanio rerio; Cell Communication and Signaling; Cell Signaling; Cell Transplantation; Cells; Coupled; Danio rerio; Data; Development; Diabetes Mellitus; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endocrine; Endoderm; Ensure; Family; Family member; Feedback; Fertility/Fertilization; Fertilization; Foregut; Fresh Water; Freshwater; Funding; Gastrointestinal Tract, Pancreas; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Germ Layers; Goals; Hour; Humulin R; In Vitro; Incidence; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Location; Mesoderm; Messenger RNA; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Mother Cells; Nesidioblasts; Novolin R; Nuclear Receptors; Organ; Organism-Level Process; Organismal Process; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Physiologic Processes; Physiological Processes; Play; Population; Position; Positioning Attribute; Primitive foregut structure; Process; Progenitor Cells; Proteins; Publishing; RNA, Messenger; Reagent; Regulation; Retinoic Acid; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Specific qualifier value; Specified; Staging; Stem cells; Techniques; Testing; Tissues; To specify; Trans Vitamin A Acid; Transcript; Transplantation; Tretinoin; Tretinoinum; Undifferentiated; Vertebrate Animals; Vertebrates; Vitamin A Acid; Work; Zebra Danio; Zebra Fish; Zebrafish; all-trans-Retinoic Acid; all-trans-Vitamin A acid; beta cell development; biological signal transduction; cell type; diabetes; diabetic patient; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; gain of function; gene function; gene product; human stem cells; inhibitor; inhibitor/antagonist; insight; islet development; islet progenitor; knock-down; loss of function; mRNA; member; microarray technology; mutant; novel; pancreas development; pathway; progenitor; public health relevance; research study; social role; trans-Retinoic Acid; transcription factor; transplant; vertebrata",Regionalization of the Vertebrate Endoderm," Relevance The long-term goal of this proposal is to inform efforts to cure diabetes by cell-transplantation. Our general strategy is to make use of the zebrafish, a small fresh-water aquarium species, as a convenient model system to study how the vertebrate pancreas forms during normal embryonic development. Our rationale is that an increased understanding of the intricacies of this process will prove invaluable to the development of methodology to differentiate human stem cells into pancreatic -cells and other endocrine cell types in vitro.",64973,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,6,370656,
7758716,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK066999-07,,NIDDK:358855;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,,08,613338789,US,CA,941211545,NORTHERN CALIFORNIA INSTITUTE RES & EDUC,"GRUNFELD, CARL ;",1881155;,5R01DK066999,03/01/2004,01/31/2012,"6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; AIDS Virus; APV; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Amprenavir; Animal Welfare; Anti-Retroviral Agents; Anti-atherogenic; Antiatherogenic; Antiretroviral Agents; Apo A-1; Apo A-I; Apo A1; Apo AI; ApoA-1; ApoA-I; Apolipoprotein A-1; Apolipoprotein A-I; Apolipoprotein A1; Apolipoprotein AI; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bibliography; Blood Circulation; Bloodstream; Carbamic acid, (3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(- phenylmethyl)propyl)-, tetrahydro-3-furanyl ester, (3S-(3R*(1S*,2R*)))-; Circulation; Counseling; Country; Doctor of Philosophy; Drugs; EFV; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; HDL; HDL Cholesterol; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Heavy Lipoproteins; High Density Lipoprotein Cholesterol; High Density Lipoproteins; High density lipoprotein; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Hyperglyceridemia; Hypertriglyceridemia; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Intermediary Metabolism; International; Kaletra; LAV-HTLV-III; Letters; Lipoproteins, HDL; Lipoproteins, HDL Cholesterol; Lipoproteins, VLDL; Lopinavir/Ritonavir; Lymphadenopathy-Associated Virus; METBL; Mediating; Medication; Metabolic Processes; Metabolism; Methods; NNRTI; Names; Paper; Patients; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Prebeta-Lipoproteins; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; RTV; Raised TG; Raised triglycerides; Regimen; Research; Research Ethics Committees; Research Resources; Resources; Ritonavir; T-Lymphotropic Virus Type III Infections, Human; Time; Toxic effect; Toxicities; Triacylglycerol; Triglyceride increased; Triglycerides; Triglycerides high; VLDL; VLDL triacylglycerol; VLDL triglyceride; Vasodilatation; Vasodilation; Vasorelaxation; Vertebrate Animals; Vertebrates; Very low density lipoprotein; Virus-HIV; abstracting; alpha-Lipoprotein Cholesterol; alpha-Lipoproteins; anti-retroviral; antiretroviral; atheromatosis; atherosclerotic vascular disease; base; design; designing; drug/agent; efavirenz; elevated tg; elevated triglyceride; expiration; glucose metabolism; healthy volunteer; human subject; insulin resistant; insulin secretion; lipoprotein, VLDL triglyceride; non-nucleoside RT inhibitors; non-nucleoside reverse transcriptase inhibitors; nonnucleoside reverse transcriptase inhibitors; norvir; particle; programs; stable isotope; tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; treatment strategy; vertebrata; very low density lipoprotein triglyceride",Effects of Antiretroviral Drugs on Metabolism,,66999,ACE,AIDS Clinical Studies and Epidemiology Study Section,,7,358855,
7765493,R01,DK,5,,02/01/2010,01/31/2011,PA-01-112,5R01DK067582-05,,NIDDK:248735;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MORGANTOWN,UNITED STATES,PHYSIOLOGY,01,191510239,US,WV,265066845,WEST VIRGINIA UNIVERSITY,"BROCK, ROBERT W;",7756420;,5R01DK067582,02/01/2007,01/31/2012,"3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); Accounting; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Affect; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-atherogenic; Anti-inflammatory; Antiatherogenic; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Bioavailability; Biochemical; Biochemistry; Biologic Availability; Biological; Biological Availability; Blood Plasma; Blood capillaries; C-Peptide; Capillaries; Capillary; Capillary, Unspecified; Cells; Chemistry, Biological; Chronic; Clinical; Clinical Research; Clinical Study; Coenzyme II; Complex; Complications of Diabetes Mellitus; Connecting Peptide; D-Glucose-6-phosphate[{..}]NADP+ 1-oxidoreductase; Data; Defect; Development; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetes-Related Complications; Diabetic Angiopathies; Diabetic Complications; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Diabetic mouse; Dysfunction; EC 1.1.1.49; EC 1.14.13.39; EDRF Synthase; ESRD; End stage renal failure; End-Stage Kidney Disease; Endothelial Cells; Endothelium-Derived Growth Factor Synthase; Environment; Enzyme Inhibition; Enzymes; Event; Exhibits; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Functional disorder; G6PD; Generations; Glucose-6-Phosphate Dehydrogenase; Glucosephosphate Dehydrogenase; Guanylyl Cyclase-Activating Factor Synthase; Heme; Heme b; Hexose Monophosphate Shunt; Humulin R; IDD; IDDM; Impairment; In Vitro; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Investigators; Kidney; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Link; Maintenance; Maintenances; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Methods and Techniques; Methods, Other; Mice; Microcirculation; Microscopy; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NADPH Oxidase; NADPH-Diaphorase; NO Synthase; Nature; Nicotinamide-Adenine Dinucleotide Phosphate; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Novolin R; Oxidants; Oxidation-Reduction; Oxidizing Agents; Oxygenases; Pancreatic Hormones; Pathogenesis; Pathway interactions; Pb element; Pentose Phosphate Pathway; Pentose Phosphate Shunt; Pentose Shunt; Pentosephosphate Pathway; Pentosephosphate Shunt; Peptide Synthesis; Peroxidases; Physiologic; Physiologic Availability; Physiological; Physiopathology; Plasma; Process; Production; Programs (PT); Programs [Publication Type]; Protoheme; Protoheme IX; Recovery; Redox; Regulation; Renal Disease, End-Stage; Renal function; Research; Research Personnel; Researchers; Rest; Reticuloendothelial System, Serum, Plasma; Role; Serum, Plasma; Source; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; Techniques; Triphosphopyridine Nucleotide; Type 1 diabetes; Uncertainty; Urinary System, Kidney; Vascular Diseases; Vascular Disorder; Vasomotor; Work; adenylcyclase; anti-oxidant; base; bioavailability of drug; bioimaging; bioimaging/biomedical imaging; biomedical imaging; blood vessel disorder; capillary; diabetes; diabetic; doubt; electron acceptor; ferroheme; functional restoration; glycemic control; heavy metal Pb; heavy metal lead; improved; in vivo; innovate; innovation; innovative; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; kidney function; membrane structure; microvascular complications; microvascular complications of diabetes; microvascular disease; mouse model; mouse model of diabetes; non-diabetic; nondiabetic; novel; novel therapeutic intervention; oxidation reduction reaction; pancreas hormone; pathophysiology; pathway; programs; renal; response; restore function; restore functionality; restore lost function; social role; type I diabetes; type I diabetic",C-peptide: protection aganist disbetic complications,,67582,HM,Hypertension and Microcirculation Study Section,,5,248735,
7743459,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK068366-05,,NIDDK:273752;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LYNCH, JOHN P;",3064545;,5R01DK068366,04/01/2006,12/31/2010,"Apoptosis; Apoptosis Pathway; Binding; Binding (Molecular Function); Biological; Biological Models; Biology; CAM 120/80; CTNNB1; CUL-2; Cadherin-1; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancer Cause; Cancer Etiology; Carbonate hydro-lyase; Carbonic Anhydrases; Catenin, Beta-1; Cell Adhesion; Cell Culture System; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell model; Cell-Cell Adhesion; CellLine; Cells; Cellular Adhesion; Cellular Migration; Cellular Morphology; Cellular Proliferation; Cellular model; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Columnar Cell; Complex; Deletion Mutagenesis; Disease; Disorder; E-Cadherin; Engineering; Engineerings; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Event; Gene Expression; Generalized Growth; Growth; Heterograft; Homeo Domain; Human; Human, General; In Vitro; Intestinal; Intestines; Investigators; Knowledge; Malignant Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Morphogenesis; Morphology; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Murine; Mus; Mutate; Newly Diagnosed; PRO2286; PTP-1B; PTP1B; PTPN1; PTPN1 gene; Pathogenesis; Phosphorylation; Phosphorylation Site; Polyps; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Programs (PT); Programs [Publication Type]; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Regulation; Research; Research Personnel; Researchers; Resistance; Role; SCID; SCID Mice; Severe Combined Immunodeficient Mice; Site; Testing; Tissue Growth; Transgenic Mice; Transplantation, Heterologous; Tyrosine Phosphorylation; United States; Uvomorulin; Xenograft; Xenograft procedure; Xenotransplantation; adenoviral-mediated; angiogenesis; base; beta catenin; bowel; cancer cell; cancer progression; carbonate dehydratase; cell morphology; cell motility; colon carcinogenesis; cultured cell line; disease/disorder; domain mapping; gene product; homeodomain; improved; in vivo; inhibitor; inhibitor/antagonist; insight; migration; neoplasm progression; neoplastic; neoplastic progression; new therapeutic target; novel; ontogeny; overexpression; programs; protein protein interaction; resistant; severe combined immune deficiency; social role; transcription factor; tumor growth; tumor progression",Cdx2 modulates beta-catenin activity in intestinal cells,,68366,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,,5,273752,
7741219,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK070790-05,,NIDDK:293547;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,PEDIATRICS,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"HRUSKA, KEITH A;",1868520;,5R01DK070790,12/23/2005,11/30/2010,"1 alpha,25-Dihydroxycholecalciferol; 1 alpha,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D3; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-; Affect; Anabolism; Anemia; Animal Model; Animal Models and Related Studies; Animals; Attention; Biological Bone Remodeling; Blood Coagulation Factor IV; Blood Pressure, High; Blood Serum; Body Tissues; Bone Diseases; Bone Formation; Ca++ element; Calcitriol; Calcium; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Chronic; Chronic Kidney Failure; Chronic Renal Disease; Clinical; Coagulation Factor IV; Complication; Data; Development; Diet; Disease; Disease Resistance; Disorder; Dysfunction; Dyslipidemias; ECSF; Endocrine Glands; Endocrine Organs; Epoetin; Erythropoietin; Excess Mortality; Factor IV; Fats; Fatty acid glycerol esters; Functional disorder; Hand; Hydroxyapatites; Hyperparathyroidism, Secondary; Hypertension; Hypocalcemia; Hypocalcemia result; Injury; Innate Bone Remodeling; Insulin Resistance; Intermediary Metabolism; Intracellular Communication and Signaling; Ions; Kidney; Kidney Diseases; Kidney Failure, Chronic; Link; Lipoprotein LDL Receptors; Low Density Lipoprotein Receptor; METBL; Mammals, Mice; Metabolic Processes; Metabolic syndrome; Metabolism; Mice; Modeling; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle, Smooth, Vascular; Nephropathy; Normal Bone Remodeling; Obesity; Organ System, Cardiovascular; Osteoblasts; Osteogenesis; Outcome; P element; PTH (1-84); PTH protein, human; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormones; Phenotype; Phosphates; Phosphorus; Physiopathology; Play; Prevention; Production; Receptors, LDL; Renal Disease; Renal Failure, Chronic; Renal Osteodystrophy; Resistance, Disease; Role; Secondary Hyperparathyroidism; Secondary Hyperparathyroidisms; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Skeleton; Study models; Testing; Therapeutic Agents; Therapeutic Effect; Tissues; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular calcification; Vascular, Heart; adiposity; biological signal transduction; biosynthesis; bone disorder; bone morphogenic protein; chronic kidney disease; circulatory system; corpulence; corpulency; corpulentia; design; designing; disease/disorder; erythrocyte colony stimulating factor; feeding; hPTH(1-84); hematopoietin; human PTH protein; hyperpiesia; hyperpiesis; hypertensive disease; inorganic phosphate; insight; insulin resistant; kidney disorder; model organism; new therapeutic target; obese; obese people; obese person; obese population; parathormone; parathyroid hormone, human; pathophysiology; pre-clinical; preclinical; prevent; preventing; renal; renal disorder; resistance to disease; resistant disease; resistant to disease; skeletal; social role",Renal Osteodystrophy and Vascular Calcification,,70790,PBKD,Pathobiology of Kidney Disease Study Section,,5,293547,
7784549,R01,DK,5,,03/01/2010,02/28/2011,,5R01DK071084-06,,NIDDK:266651;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MIAMI,UNITED STATES,SURGERY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"VELAZQUEZ, OMAIDA C;",1904688;,5R01DK071084,03/15/2006,02/28/2011,"3D modeling; Acute; Adenoviral Vector; Adenovirus Vector; Agonist; Amputation; Architecture; Area; Beds; Body Tissues; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Chronic; Collagen; Complement; Complement Proteins; Complex; Corium; Cutaneous; Cutis; DNA Molecular Biology; Defect; Dermis; Development; Diabetes Mellitus; Diabetic mouse; Differentiation and Growth; Endothelial Cells; Engineering / Architecture; Epidermis; Extremities; Fibroblasts; Foot Ulcer; GFAC; Goals; Grafting, Bone Marrow; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Healed; Healing abnormal; Healing delayed; Human; Human, General; Impaired healing; Impaired tissue repair; Impaired wound healing; In Vitro; Infection; Intracellular Communication and Signaling; Invaded; Knowledge; Label; Leg; Limb structure; Limbs; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mediating; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Mice; Modeling; Molecular Biology; Murine; Mus; Myofibroblast; Non-Trunk; Overexpression; PDGF; PDGF, B Chain; PDGF-2; PDGFB; Patients; Platelet Derived Growth Factor Beta Chain; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor B; Platelet-Derived Growth Factor Beta; Platelet-Derived Growth Factor, B Chain; Platelet-Derived Growth Factor, Beta Polypeptide; Population; Process; Proliferating; Protein Overexpression; Proto-Oncogene Products c-sis; Proto-Oncogene Proteins c-sis; Recruitment Activity; Rest; Reticuloendothelial System, Bone Marrow; Role; SIS Gene Product; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Tensile Strength; Testing; Tissues; Viral Vector; Work; Wound Healing; Wound Repair; abnormal tissue repair; adeno vector; adenovector; angiogenesis; biological signal transduction; c-sis Proteins; cell type; cytokine; delayed wound healing; diabetes; diabetic; diabetic patient; diabetic wound healing; experiment; experimental research; experimental study; healing; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; keratinocyte; keratinocyte differentiation; migration; mouse model of diabetes; neovascularization; new therapeutics; next generation therapeutics; novel; novel therapeutics; overexpress; precursor cell; reconstitute; reconstitution; reconstruction; recruit; repair; repaired; research study; sis Proto-Oncogene Proteins; social role; stem cell population; three-dimensional modeling; tissue repair; vasculogenesis; wound",Bone marrow-derived fibroblasts in skin wound healing,,71084,SAT,"Surgery, Anesthesiology and Trauma Study Section",,6,266651,
7767759,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK071125-04,,NIDDK:248216;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"ZUCKER, STEPHEN D;",1862581;,5R01DK071125,02/01/2007,01/31/2011,"21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-; AHR; Active Oxygen; Adhesion Molecule; Allergens; Androstanes; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Aryl Hydrocarbon Receptor; Bile Pigments; Bilirubin; Bilirubin IX alpha; Bilirubin, total; Blood Serum; Blood Vessels; Blood leukocyte; CD54 (ICAM 1); CD54 Antigens; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Signaling; EC 1.1.3.22; Endothelial Cells; Endotoxins; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Foundations; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); HIF 1; HIF-1 protein; HIF1; HIF1 protein; Heme; Heme b; Hepatocyte Nitric Oxide Synthase; Hepatotoxic effect; Hepatotoxicity; Hypoxanthine Dehydrogenase; Hypoxanthine Oxidase; Hypoxanthine-Xanthine Oxidase; ICAM-1; INFLM; INOS; In Situ; Inducible Nitric Oxide Synthase; Inflammation; Inflammatory; Inflammatory Response; Ink; Intercellular adhesion molecule 1; Intracellular Communication and Signaling; Investigation; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; LPS; Leukocytes; Lipopolysaccharides; Liver Toxicity; MAP Kinase 8; MAPK8 Mitogen-Activated Protein Kinase; Macrophage Nitric Oxide Synthase; Marrow leukocyte; Mediating; Mitogen-Activated Protein Kinase 8; NADPH Oxidase; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide Synthase 2A; Nuclear Translocation; Nuclear Translocator; Oxygen Radicals; Physiologic; Physiological; Play; Pneumonia; Pneumonitis; Pro-Oxidants; Property; Property, LOINC Axis 2; Protoheme; Protoheme IX; Pulmonary Inflammation; Purine-Xanthine Oxidase; Reactive Oxygen Species; Receptor Protein; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Regulation; Research; Reticuloendothelial System, Leukocytes; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; TCDD Receptors; Testing; Therapeutic; Toxic effect on liver cells; Up-Regulation; Up-Regulation (Physiology); Upregulation; White Blood Cells; White Cell; Xanthine Oxidase; Xanthine[{..}]oxygen oxidoreductase; androstane compound; aryl hydrocarbons; base; biological signal transduction; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cell adhesion protein; constitutive androstane receptor; design; designing; dioxin receptor, nuclear translocator; effective therapy; experiment; experimental research; experimental study; ferroheme; hepatoxicity; human NOS2A protein; hypoxia inducible factor 1; iNOS enzyme; inhibitor; inhibitor/antagonist; insight; jun-NH2-Terminal Kinase; macrophage; migration; nitric oxide synthase, Type II; prevent; preventing; receptor; research study; response; social role; stress-activated protein kinase 1; transcription factor; vascular; white blood cell; white blood corpuscle",Anti-inflammatory Properties of Bilirubin,,71125,HBPP,Hepatobiliary Pathophysiology Study Section,,4,248216,
7759127,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK071707-04,,NIDDK:284591;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,COLLEGE STATION,UNITED STATES,VETERINARY SCIENCES,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"CHAPKIN, ROBERT STEPHEN;",1864268;,5R01DK071707,02/15/2007,01/31/2012,"ATGN; Address; Affect; Allergic; Allergy; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigens; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Attenuated; Autoimmune; Autoimmune Process; Autoimmune Status; Autoimmunity; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Membrane Lipids; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell membrane; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Clinical Research; Clinical Study; Communicable Diseases; Complex; Complexes, Macromolecular; Cytokine Activation; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytoplasmic Membrane; DHA; Data; Development; Disease; Disease Resistance; Disorder; Docosahexaenoic Acids; Docosahexenoic Acids; Effector Cell; Environment; Epidemiology; Equilibrium; Fats; Fatty Acids, Omega-3; Fatty Acids, Polyunsaturated; Fatty acid glycerol esters; Goals; Guidelines; Health; Hypersensitivity; IL-10; IL10; IL10A; INFLM; Immune; Immune response; Immune system; Incidence; Individual; Infectious Agent; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interleukin 10 Precursor; Interleukin-10; Intracellular Communication and Signaling; Knockout Mice; Lead; Lipid Rafts, Cell Membrane; Lipids; MHC Receptor; Macromolecular Complexes; Maintenance; Maintenances; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Membrane; Membrane Lipids; Membrane Microdomains; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Murine; Mus; Null Mouse; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Outcome; Pathogenesis; Pathologic; Pb element; Phosphatides; Phospholipids; Plasma Membrane; Play; Polyunsaturated Fatty Acids; Production; Property; Property, LOINC Axis 2; Pupa; Receptor Activation; Receptor Signaling; Receptors, Antigen, T-Cell; Resistance; Resistance, Disease; Role; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Subcellular Process; T Cell Receptor Signaling Pathway; T-Cell Activation; T-Cell Proliferation; T-Cell Receptor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocytes; Testing; Th-1 Cell; Th-2 Cell; Th1 Cells; Th2 Cells; Thymus-Dependent Lymphocytes; Transgenic Mice; Type 1 Helper Cell; Type 2 Helper Cell; Vaccination; Work; balance; balance function; bioactive food component; biological signal transduction; body system, allergic/immunologic; design; designing; disease/disorder; experiment; experimental research; experimental study; extracellular; feeding; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunoresponse; in vivo; infectious organism; lipid raft; membrane structure; mouse model; n-3 Fatty Acids; new therapeutics; next generation therapeutics; novel therapeutics; omega-3; organ system, allergic/immunologic; pathogen; plasmalemma; polarized cell; polyunsaturated fatty acid; prevent; preventing; protective effect; protein function; research study; resistance to disease; resistant; resistant disease; resistant to disease; response; self recognition (immune); social role; thymus derived lymphocyte; tool",n-3 Fatty Acids Alter T-cell Activation and Signaling,,71707,INMP,Integrative Nutrition and Metabolic Processes Study Section,,4,284591,
7746354,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK071888-05,,NIDDK:228951;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,EAST LANSING,UNITED STATES,CHEMISTRY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"SPENCE, DANA M;",6803510;,5R01DK071888,01/15/2007,12/31/2010,"ATP; Adenosine 5'-(tetrahydrogen triphosphate); Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Adenosine Triphosphate; Adenylpyrophosphate; Antioxidants; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Circulation; Blood Pressure; Blood Pressure, High; Blood erythrocyte; Blood normocyte; Bloodstream; Body Tissues; Cell Line; Cell Lines, Strains; CellLine; Chemicals; Circulation; Coenzyme II; Complications of Diabetes Mellitus; Detection; Development; Devices; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes-Related Complications; Diabetic Complications; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium; Endothelium-Derived Relaxing Factor; Erythrocyte Deformability; Erythrocyte Filterability; Erythrocytes; Erythrocytic; Health; Hexose Monophosphate Shunt; Hypertension; Intermediary Metabolism; Lab On a Chip; Leiomyocyte; Literature; METBL; MODY; Mammals, Rabbits; Marrow erythrocyte; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Metabolic Pathway; Metabolic Processes; Metabolism; Methods; Microcirculation; Microfluidic Device; Microfluidic Lab-On-A-Chip; Microfluidic Microchips; Monitor; Mononitrogen Monoxide; Myocytes, Smooth Muscle; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NIDDM; Nicotinamide-Adenine Dinucleotide Phosphate; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; O element; O2 element; Oryctolagus cuniculus; Outcome; Oxygen; Patients; Pentose Phosphate Pathway; Pentose Phosphate Shunt; Pentose Shunt; Pentosephosphate Pathway; Pentosephosphate Shunt; Physiologic; Physiological; Production; Rabbit, Domestic; Rabbits; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relaxation; Reporting; Resistance; Reticuloendothelial System, Erythrocytes; Role; Scheme; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; System; System, LOINC Axis 4; T2D; T2DM; Technology; Time; Tissues; Triphosphopyridine Nucleotide; Type 2 diabetes; Type II diabetes; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; adult onset diabetes; anti-oxidant; base; blood corpuscles; cultured cell line; diabetes; diabetic; endothelial cell derived relaxing factor; hyperpiesia; hyperpiesis; hypertensive disease; improved; ketosis resistant diabetes; maturity onset diabetes; micro-total analysis system; mu-TAS; resistant; social role",Monitoring Red Cell Metabolism using a Lab on a Chip,,71888,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,5,228951,
7764797,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK072277-04,,NIDDK:306089;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ITHACA,UNITED STATES,OTHER BASIC SCIENCES,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"KOTLIKOFF, MICHAEL I.;",1895188;,5R01DK072277,02/01/2007,01/31/2011,"Affect; Alimentary Canal; BACs (Chromosomes); Bacterial Artificial Chromosomes; Bladder; Bladder, Overactive; Ca Release Channel-Ryanodine Receptor; Calcium-Ryanodine Receptor Complex; Cardiac; Cell Communication and Signaling; Cell Signaling; Complex; Coupling; Cyclicity; Data; Development; Digestive Tract; Disease; Disorder; Dysfunction; Frequencies (time pattern); Frequency; Functional disorder; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Transfer Techniques; Generations; Genetic; HTRPY; Heart; Hormonal; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hypertrophy; ICC (Interstitial cell of Cajal); Image; Imagery; Imaging technology; In Vitro; Incontinence; Individual; Interstitial Cell of Cajal; Interstitial cell of Cajal (ICC); Intracellular Communication and Signaling; Leiomyocyte; Life; Mammals, Mice; Maps; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Molecular; Monitor; Morbidity; Morbidity - disease rate; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Muscle, Involuntary; Muscle, Smooth; Myocytes; Myocytes, Smooth Muscle; Nature; Nerve; Nervous; Noise; Obstruction; Organ; Overactive Bladder; Pace Stimulators; Pacemakers; Pattern; Periodicity; Physiologic; Physiological; Physiopathology; Play; Property; Property, LOINC Axis 2; QOL; Quality of life; Receptors, Ryanodine; Regulation; Resolution; Rhythmicity; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Sarcoplasmic Reticulum; Secondary to; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Source; Stimulators, Electrical, Pace; Surface; Symptoms; Syndrome; Techniques; Temperature; Testing; Transgenesis; Transgenic Mice; Urge Incontinence; Urgency of micturition; Urgency to pass urine; Urgent desire to urinate; Urinary System, Bladder; Urinary tract; Urination; V (voltage); Visualization; alimentary tract; base; biological signal transduction; cholinergic; cholinergic neuron; digestive canal; disease/disorder; imaging; in vivo; micturition; micturition urgency; molecular scale; neural; nodal myocyte; novel; pathophysiology; psychologic; psychological; relating to nervous system; selective expression; selectively expressed; social; social role; tool; uRNA; urinary bladder; urinary urgency; urination urgency; voiding; voltage",In Vivo Ca2+ and Voltage Imaging on The Urinary Bladder,,72277,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,4,306089,
7755010,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK072932-04,,NIDDK:472442;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,EUGENE,UNITED STATES,,04,053615423,US,OR,97403,OREGON RESEARCH INSTITUTE,"STICE, ERIC M;",1894653;,5R01DK072932,02/01/2007,01/31/2012,"Active Follow-up; Affect; Attention; Behavior; Behavioral; Blinded; Body Image; Bulimia; Bulimias; Caloric Intake; Clinical; Clinical Psychology; Development; Diagnostic; Dietary intake; Eating; Eating Disorders; Emotional Depression; Energy Intake; Female; Female Adolescents; Food Intake; Functional impairment; Future; Goals; Hydrogen Oxide; Individual; Intervention; Intervention Strategies; Interview; Label; Measures; Mediating; Methods and Techniques; Methods, Other; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nervosa, Bulimia; Obesity; Outcome; Parents; Participant; Patient Self-Report; Persuasion; Persuasive Communication; Physical activity; Prevention program; Preventive Intervention; Programs (PT); Programs [Publication Type]; Psychology, Clinical; Psychopathology; Public Health; Randomized; Randomized Controlled Trials; Recruitment Activity; Relative; Relative (related person); Resistance; Risk; SUBGP; Sampling; Self-Report; Structure; Subgroup; Symptoms; Symptoms of depression; Techniques; Testing; Water; Weight; Weight Gain; Weight Increase; Weight maintenance regimen; abnormal psychology; adiposity; adolescent girl; aged; body dissatisfaction; body weight gain; body weight increase; caloric dietary content; cigarette smoking; college; corpulence; corpulency; corpulentia; depressive; depressive symptoms; follow-up; functional disability; high risk; improved; intervention effect; interventional strategy; obese; obese people; obese person; obese population; obesity prevention; obesity risk; preventional intervention strategy; programs; psychoeducational; public health medicine (field); public health relevance; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; recruit; resistant; satisfaction; selected prevention; selective prevention; selective preventive intervention; selective preventive measure; smoke cigarette; social; weight control; weight gain prevention; wt gain",Targeted Obesity Prevention Program for Adolescent Females,,72932,PRDP,Psychosocial Risk and Disease Prevention Study Section,,4,472442,
7755008,R01,DK,5,,02/01/2010,01/31/2011,DK-04-013,5R01DK072994-05,,NIDDK:701453;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN DIEGO,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,53,073371346,US,CA,92182,SAN DIEGO STATE UNIVERSITY,"ELDER, JOHN P;",1875765;,5R01DK072994,03/10/2006,01/31/2011,"0-11 years old; 9 year old; Acculturation; Acculturations; Advocate; Behavior; Behavioral; Beverages; Child; Child Youth; Childhood; Children (0-21); Communities; Community Health; Conditional Variables; Cultural Assimilation; Eating; Eating Behavior; Effect Modifiers (Epidemiology); Effectiveness; Environment; Environmental Factor; Environmental Risk Factor; Ethnic Origin; Ethnicity; Ethnicity aspects; Family; Food Intake; Health; Home; Home environment; Household; Human, Child; Intervention; Intervention Strategies; Lead; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Moderator Variables; Modifiers, Epidemiologic Effect; Neighborhoods; Nutrition; Nutritional Science; Obesity; Outcome; Over weight; Overweight; Pattern; Pb element; Physical activity; Race; Racial Group; Recreation; Research; Research Resources; Resources; Science of nutrition; Site; Stocks, Racial; Weight; Work; adiposity; base; children; corpulence; corpulency; corpulentia; demographics; design; designing; environmental change; environmental risk; fruits and vegetables; heavy metal Pb; heavy metal lead; innovate; innovation; innovative; interventional strategy; nine year old; nutrition; obese; obese people; obese person; obese population; obesity prevention; pediatric; prevent; preventing; sedentary; sugar; youngster",Obesity Prevention/Control /Community Recreation Centers,,72994,ZRG1,Special Emphasis Panel,,5,701453,
7742668,R01,DK,5,,01/01/2010,12/31/2010,DK-04-013,5R01DK073025-05,,NIDDK:433429;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"LUDWIG, DAVID S;",1931522;,5R01DK073025,02/21/2006,12/31/2010,"0-11 years old; 21+ years old; Accounting; Adolescent; Adolescent Youth; Adult; Area; BMI percentile; BMI z-score; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Beverages; Body Weight; Body Weight decreased; Body fat; Body mass index; Boston; Caloric Intake; Child; Child Youth; Childhood; Children (0-21); City of Boston; Conditioning Therapy; Consumption; Control Groups; Counseling; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Diet; Disease Frequency Surveys; Education; Educational aspects; Energy Intake; Environment; Epidemic; Family; Fostering; Future; Home; Home environment; Human; Human, Adult; Human, Child; Human, General; Incidence; Intervention; Intervention Strategies; Life Style Modification; Link; Liquid substance; Longitudinal Studies; Man (Taxonomy); Man, Modern; Measures; Obesity; Over weight; Overweight; Parents; Participant; Phone; Physiologic; Physiological; Pilot Projects; Prevention; Preventive Intervention; Public Health Applications; Public Health Applications Research; Quetelet index; Randomized; Reporting; Risk; Schools; Site; Source; Students; Supermarket; Telephone; Testing; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Youth; Youth 10-21; adiposity; adult human (21+); after-school program; base; behavior intervention; behavioral intervention; body weight gain; body weight increase; body weight loss; caloric dietary content; children; corpulence; corpulency; corpulentia; design; designing; drinking; fluid; fruits and vegetables; high school; intervention design; interventional strategy; juvenile; juvenile human; liquid; long-term study; middle school; obese; obese people; obese person; obese population; obesity in children; obesity prevention; pediatric; peer; pilot study; preventional intervention strategy; randomisation; randomization; randomly assigned; response; role model; soft drink; sugar; sweetened beverage; therapy design; treatment design; wt gain; wt-loss; youngster",Reducing Sugar-Sweetened Beverage Consumption in Overweight Adolescents,,73025,ZRG1,Special Emphasis Panel,,5,433429,
7754895,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK073120-05,,NIDDK:344772;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"ALBANESI, JOSEPH P;",1936046;,5R01DK073120,02/01/2006,12/31/2010,"ANF receptor B; ANPB; ANPRB; ATP-protein phosphotransferase; Acute; Adipocytes; Adipose Cell; Adipose tissue; Americas; Ammon Horn; Angioplasty; Animals; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atrial Natriuretic Peptide B-Type Receptor; Atrial Natriuretic Peptide Receptor B; Atrionatriuretic Peptide Receptor B; Autocrine Systems; B-type natriuretic peptide receptor; Blood Pressure, High; Blood Serum; Body Tissues; Body Weight; Bone; Bone and Bones; Bones and Bone Tissue; Breeding; C-Type Natriuretic Peptide; CNP-22; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chondrocytes; Clinic; Complement; Complement Proteins; Cornu Ammonis; Dentate Fascia; Dentate Gyrus; Deoxyguanylate Cyclase; Dephosphorylation; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Dwarfism; Eating; Edg Receptors; Embryo; Embryonic; Fascia Dentata; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Fibroblasts; Figs; Figs - dietary; Food Intake; G-Proteins; GC-B; GTP pyrophosphate-lyase (cyclizing); GTP-Binding Proteins; GTP-Regulatory Proteins; GUC2B; Genes; Genetic; Genetic Models; Genome; Genomics; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanyl Cyclase; Guanylate Cyclase; Guanylate Cyclase B; Gyrus Dentatus; HTRPY; Health; Hepatic Disorder; Hippocampus; Hippocampus (Brain); Hypertension; Hypertrophy; Immune Precipitation; Immunoprecipitation; In Vitro; Inhibition of Cell Proliferation; Inosinate Cyclase; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Lesion; Life; Ligands; Lipocytes; Lipolysis; Liver; Liver diseases; MODY; Mammals, Mice; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Medical; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Models, Genetic; Molecular; Molecular Target; Murine; Mus; NIDDM; NPRB; Nanism; Natriuretic Peptide Receptor B; Natriuretic Peptide, C-Type; Negative Control of Cell Proliferation; Negative Regulation of Cell Proliferation; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nucleic Acid Regulatory Sequences; Null Mouse; Obesity; Pathway interactions; Phenotype; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphorylation Site; Physiologic; Physiological; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dephosphorylation; Protein Kinase; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Protocol; Protocols documentation; RNA, Small Interfering; Receptor Activation; Receptor Gene; Receptor Protein; Receptor Signaling; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research; Research Personnel; Researchers; Risk Factors; Role; S1P Receptor; Scheme; Serum; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Sphingosine-1-Phosphate Receptor; Structure of dentate gyrus; T2D; T2DM; Therapeutic; Tissues; Transgenes; Transgenic Organisms; Translations; Two Hybrid; Type 2 diabetes; Type II diabetes; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; Wound Healing; Wound Repair; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; adipocyte development; adipocyte differentiation; adipose; adiposity; adult onset diabetes; analog; atheromatosis; atherosclerotic vascular disease; atrial natriuretic factor receptor B; autocrine; base; biological signal transduction; body system, hepatic; bone; corpulence; corpulency; corpulentia; cultured cell line; dentate gyrus; desensitization; disease/disorder; established cell line; experiment; experimental research; experimental study; gene product; genetic regulatory element; glycogen synthase a kinase; guanylyl cyclase; guanylyl cyclase-B receptor; hepatopathy; high risk; hippocampal; human disease; hydroxyalkyl protein kinase; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; interventional strategy; intraluminal angioplasty; ketosis resistant diabetes; knock-down; liver disorder; maturity onset diabetes; membrane structure; mouse model; obese; obese people; obese person; obese population; oncogene protein pp60(v-src) (137-157); organ system, hepatic; paracrine; pathway; peptide A; peptide C; phosphorylase b kinase kinase; polypeptide C; programs; receptor; receptor expression; research study; response; restenosis; siRNA; social role; sphingosine 1-phosphate; subcutaneous; tissue repair; transgenic; white adipose tissue; yeast two hybrid system; yellow adipose tissue",Guanylyl cyclase receptors: Targets for medical intervention,,73120,MCE,Molecular and Cellular Endocrinology Study Section,,5,344772,
7750561,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK073152-05,,NIDDK:226922;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,OMAHA,UNITED STATES,OTHER BASIC SCIENCES,02,053309332,US,NE,68178,CREIGHTON UNIVERSITY,"REIDELBERGER, ROGER ;",1866117;,5R01DK073152,02/15/2006,01/31/2011,"21+ years old; Abdomen; Abdominal; Address; Adult; Affect; Affinity; Agonist; American; Aminoacetic Acid; Antibodies; Behavioral; Binding Sites; Blood; Blood - brain barrier anatomy; Blood Circulation; Blood Plasma; Blood-Brain Barrier; Bloodstream; Body Tissues; Brain; Brain Stem; Brain region; Brainstem; CCK; Caloric Intake; Cancers; Cannulas; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Cells; Cholecystokinin; Circulation; Combining Site; Common Rat Strains; Coupled; Denervation; Depression; Development; Diabetes Mellitus; Distal; Dose; Eating; Encephalon; Encephalons; Endocrine; Energy Intake; Environmental Factor; Environmental Risk Factor; Family; Food Intake; Food Intake Regulation; GLP-1; Gastrointestinal Tract, Pancreas; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Glycine; Hand; Health Care Costs; Health Costs; Healthcare Costs; Heart Diseases; Hemato-Encephalic Barrier; Hormonal; Human; Human, Adult; Human, General; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; IAPP; Infusion; Infusion procedures; Inherited Predisposition; Inherited Susceptibility; Insulinoma amyloid peptide; Interacinar Cell Pancreatic Polypeptide; Intestinal; Intestines; Intracellular Communication and Signaling; Investigators; Isoforms; Jugular Veins; Leptin; Life Style; Lifestyle; Ligands; Link; Malignant Neoplasms; Malignant Tumor; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medulla Oblongata; Mental Depression; Methods; Myelencephalon; Nerve; Nervous; Nervous System, Brain; Nervous System, Pituitary; Neuropeptide Tyrosine; Nutrient; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Obesity associated disease; Obesity related disease; Over weight; Overweight; PYY Peptide; Pancreas; Pancreatic; Pancreatic Polypeptide; Pancreozymin; Peptide YY; Peptides; Peripheral; Phosphorylated Peptide; Physiologic; Physiological; Pituitary; Pituitary Gland; Plasma; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Prevalence; Prevention strategy; Preventive strategy; Production; Protein Isoforms; Proteomics; Rat; Rattus; Reactive Site; Receptor Protein; Reporting; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Rodent; Rodentia; Rodentias; Satiation; Satiations; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Stomach; Structure of jugular vein; Testing; Tissues; Uropancreozymin; Visceral; adiposity; adult human (21+); amlintide; amylin; anorexigenic peptide; base; biological signal transduction; bowel; caloric dietary content; corpulence; corpulency; corpulentia; diabetes; diabetes associated peptide; environmental risk; feeding; gastric; genetic etiology; genetic mechanism of disease; genetic vulnerability; glucagon-like peptide 1; heart disorder; hypothalamic; insulinoma amyloid polypeptide; islet amyloid polypeptide; malignancy; meetings; neoplasm/cancer; neuropeptide Y; novel; ob/ob mouse; obese; obese people; obese person; obese population; obesity in children; pancreatic amylin; paracrine; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; receptor; response; satiety; sedentary",Regulation of Food Intake and Body Adiposity by Peptide YY,,73152,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,5,226922,
7915419,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK073189-05,,NIDDK:386843;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"BUTLER, ANDREW ;",8043887;,5R01DK073189,01/01/2007,11/30/2011,"ACTH-beta-Lipotropin Precursor; Ablation; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Adipose tissue; Affect; Arcuate Nucleus; Area; Arousal; Behavior; Behavioral; Blood Serum; Body Tissues; Boxing; Brain; Brain Stem; Brainstem; Caloric Restriction; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Central Nervous System; Circadian Rhythms; Consumption; Corticotropin-beta-Lipotropin Precursor; Cues; Cyclicity; D-Glucose; Data; Dextrose; Disease; Disease Clusterings; Disorder; Diurnal Rhythm; Eating; Elements; Encephalon; Encephalons; Endocrine; Endorphin-ACTH Precursor; Enhancers; Exhibits; Expression Profiling; Expression Signature; Family; Fatty Tissue; Feeding behaviors; Food; Food Intake; Foundations; Gene Expression; Genes; Genetic Alteration; Genetic Change; Genetic defect; Gluconeogenesis; Glucose; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Hypothalamic structure; Hypothalamus; Inflammatory; Infundibular Nucleus; Ingestive Behavior; Injection of therapeutic agent; Injections; Insulin Resistance; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Ligands; Light; Lipids; Liver; MC3 Receptor; METBL; Mammalia; Mammals; Mammals, General; Mammals, Mice; Melanocortin 3 Receptor; Messenger RNA; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolic syndrome; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Molecular Fingerprinting; Molecular Profiling; Morbidity; Morbidity - disease rate; Murine; Mus; Mutation; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Nucleus; Null Mouse; Nutrient; Nyctohemeral Rhythm; Organ; Output; POMC; Peptide Domain; Peptides; Periodicity; Peripheral; Phase; Photoradiation; Physical activity; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Pro-Opiomelanocortin; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proopiocortin; Proopiomelanocortin; Protein Domains; RNA, Messenger; Receptor, Melanocortin, Type 3; Recombinants; Regulation; Research Personnel; Researchers; Retina; Rhythmicity; Risk; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sleep; Structure; Structure of nucleus infundibularis hypothalami; Tertiary Protein Structure; Thesaurismosis; Time; Tissues; Transgenic Organisms; Twenty-Four Hour Rhythm; Viral Vector; adeno vector; adenovector; adipogenesis; adipose; attenuation; behavior test; behavioral test; biological signal transduction; body system, hepatic; calorie restriction; circadian; circadian process; daily biorhythm; disease/disorder; diurnal variation; energy balance; experiment; experimental research; experimental study; fatty acid oxidation; feeding; feeding-related behaviors; genome mutation; glucose biosynthesis; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; insulin resistant; lipid biosynthesis; lipogenesis; mRNA; male; melanocortin receptor; metabolism disorder; molecuar profile; molecular signature; neural; neuronal; nutrient intake activity; obesity risk; orexin; organ system, hepatic; programs; receptor expression; relating to nervous system; research study; response; transcription factor; transgenic; white adipose tissue; yellow adipose tissue",Melanocortin-3 Receptor Regulation of Physical Activity and Metabolism,,73189,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,5,386843,
7749546,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK073368-05,,NIDDK:285822;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ZHANG, JIN ;",8059892;,5R01DK073368,01/15/2006,12/31/2010,"2'-AMP; 2'-adenosine monophosphate; 2'-adenylic acid; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; 3T3-L1 Cells; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adipocytes; Adipose Cell; Adrenergic Agents; Adrenergic Drugs; Adrenergic Receptor; Adrenergics; Adrenoceptors; Apoptosis; Apoptosis Pathway; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Caveolae; Caveolas; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemicals; Chronic; Clinical; Coupling; Cyclic AMP; Cytoplasm; Cytoplasmic Membrane; Data; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diffusion; Embryo; Embryonic; Engineering; Engineerings; Fat Cells; Generations; Genetic Engineering of Proteins; Goals; Guanosine; Human; Human, General; Humulin R; Image; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Kidney; Knowledge; Laboratories; Lead; Learning; Life; Linkage Analysis; Lipocytes; METBL; MODY; Mammalian Cell; Man (Taxonomy); Man, Modern; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Metabolic Processes; Metabolism; Methods and Techniques; Methods, Other; Mitochondria; Molecular; Monitor; NIDDM; Nature; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; PDE; Pattern; Pb element; Phosphodiesterases; Plasma Membrane; Production; Protein Engineering; Protein Kinase; Proteins; Receptors, Epinephrine; Regulation; Research; Research Personnel; Researchers; Role; Second Messenger Systems; Second Messengers; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Subcellular Process; T2D; T2DM; Techniques; Testing; Therapeutic; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; adenoreceptor; adenosine 3'5' monophosphate; adenylcyclase; adiposity; adrenergic; adult onset diabetes; beta-adrenergic receptor; biological signal transduction; cAMP; corpulence; corpulency; corpulentia; family based linkage study; fluorescence imaging; gene product; genetic linkage analyses; genetic linkage analysis; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; imaging; innovate; innovation; innovative; ketosis resistant diabetes; linkage analyses; maturity onset diabetes; mitochondrial; obese; obese people; obese person; obese population; phosphoric diester hydrolase; phosphorylase b kinase kinase; plasmalemma; renal; second messenger; social role; spatiotemporal",Mechanisms of Compartmentalized cAMP Signaling,,73368,SBCB,Synthetic and Biological Chemistry B Study Section,,5,285822,
7745473,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK073414-04,,NIDDK:291351;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,PATHOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"CHANG, CHAWNSHANG ;",7688996;,5R01DK073414,01/01/2007,12/31/2010,"Ablation; Affect; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Apoptosis; Apoptosis Pathway; Apoptotic; Arthritis; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B-Cell Development; B-Cells; B-Lymphocytes; Blood Serum; Bone Marrow; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Death, Programmed; Cell Isolation; Cell Lineage; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collagen; Cytofluorometry, Flow; Development; Disease; Disorder; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Gene Products, RNA; Generations; Genes; Genotype; Gonadal Steroid Hormones; Immune; In Vitro; Inflammatory Response; Knock-out; Knockout; Knockout Mice; Link; Lymphopoiesis; Male Castration; Mammals, Mice; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Murine; Mus; Null Mouse; Pathway interactions; Play; Predisposition; Production; Proliferating; RNA; RNA, Non-Polyadenylated; Regulation; Resistance; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Role; Serum; Sex Hormones; Sex Steroid Hormones; Site; Stromal Cells; Susceptibility; Testing; Therapeutic Androgen; Wild Type Mouse; antibody biosynthesis; arthritic; autoimmune antibody; autoimmune disorder; cell sorting; disease/disorder; flow cytophotometry; gonadal steroids; immunoglobulin biosynthesis; in vivo; lymphocytopoiesis; male; pathogen; pathway; peripheral blood; precursor cell; resistant; self reactive antibody; self recognition (immune); sex steroid; social role",Androgen Receptor in B Cell Development and Functions,,73414,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,4,291351,
7749551,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK073462-04,,NIDDK:320215;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"BARASCH, JONATHAN M.;",8232452;,5R01DK073462,01/01/2007,11/30/2011,"21+ years old; 72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; Acute; Acute Kidney Failure; Adult; Animals; Binding; Binding (Molecular Function); Blastocytes; Blastomeres; Blood Circulation; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Bloodstream; Body Tissues; Canine Species; Canis familiaris; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular injury; Chelating Agents; Chelators; Chemical Structure; Chemicals; Childhood; Circulation; Cloning; Color; Common Rat Strains; Complex; Complexons; Conditioned Culture Media; Conditioned Medium; Crystallographies; Crystallography; Culture Media, Conditioned; Data; Distal; Dogs; Duct; Duct (organ) structure; Embryo; Embryonic; Embryonic Cell; Epithelium; Fe element; Fred Hutchinson Cancer Research Center; GFAC; Gelatinase A; Gelatinase Neutrophil; Generalized Growth; Genes; Genetics, in situ Hybridization; Grafting, Kidney; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heterophil Granulocyte; Human; Human, Adult; Human, General; In Situ Hybridization; In Vitro; Iron; Iron Chelates; Iron Chelating Agents; Ischemia-Reperfusion Injury; Kidney; Kidney Diseases; Kidney Failure, Acute; Kidney Insufficiency, Acute; Kidney Transplantation; Kidney Transplants; Kidney Tubules; Knock-out; Knockout; Ligands; Liver; MMP-2; MMP2; Mammalia; Mammals; Mammals, Dogs; Mammals, General; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Matrix Metalloproteinase-2; Mediating; Mesenchymal; Mice; Modeling; Molecular; Molecular Interaction; Murine; Mus; Nephrons; Nephropathy; Neutrophilic Granulocyte; Neutrophilic Leukocyte; PEX; Phenotype; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Protective Agents; Protective Drugs; Proteins; Rat; Rattus; Recombinants; Renal Disease; Renal Failure, Acute; Renal Insufficiency, Acute; Renal Transplantation; Renal Transplants; Renal tubule structure; Reperfusion Damage; Reperfusion Injury; Role; Rosa; Rose; Serum; Siderochromes; Siderophores; Source; Structure; Structure of blastomere; Testing; Tissue Growth; Tissues; Urinary System, Kidney; Urinary System, Urine; Urine; Uriniferous Tube; Work; adult human (21+); blastomere structure; body system, hepatic; canine; cell damage; cell injury; cultured cell line; domestic dog; gene product; in situ Hybridization Staining Method; in vivo; kidney disorder; member; neutrophil; novel; ontogeny; organ system, hepatic; overexpression; oxidative damage; pediatric; reconstitute; reconstitution; renal; renal disorder; renal epithelium; renal tubule; social role; urinary",Iron Lipcalin In Kidney Disease,,73462,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,4,320215,
7756621,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK073558-04,,NIDDK:314715;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,STANFORD,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"PASRICHA, PANKAJ J;",1921852;,5R01DK073558,01/15/2007,12/31/2010,"Afferent Neurons; BDNF; Behavioral; Blotting, Western; Body Tissues; Brain-Derived Neurotrophic Factor; CGRP; Calcitonin Gene-Related Peptide; Chronic; Clinical; Common Rat Strains; Data; Dorsal Root Ganglia; Elements; Euler-Gaddum Substance P; Ganglia, Spinal; Gastrointestinal Tract, Pancreas; Genes; Human; Human, General; Injury; Ion Channel; Ion Channels, Potassium; Ionic Channels; K channel; Knowledge; Label; MGC34632; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Membrane Channels; Methods and Techniques; Methods, Other; Modeling; Molecular; Na element; Nerve Cells; Nerve Fibers; Nerve Growth Factors; Nerve Transmitter Substances; Nerve Unit; Neural Cell; Neurobiology; Neurocyte; Neuronotrophic Factors; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropeptides; Neurotransmitters; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Nociception; Nociceptors; Pain; Painful; Pancreas; Pancreatic; Pathogenesis; Pathway interactions; Peptides; Play; Potassium Channel; Preparation; Proteins; RNA analysis; Rat; Rattus; Receptor Protein; Rodent Model; Role; SP(1-11); Sensory; Sensory Cell Afferent Neuron; Sodium; Spinal Ganglia; Stimulus; Substance P; Syndrome; TRPV1; TRPV1 gene; Techniques; Therapeutic; Tissues; V (voltage); Western Blotting; Western Blottings; Western Immunoblotting; afferent nerve; allodynia; base; chronic pancreatitis; dorsal root ganglion; gene product; in vivo; laser capture microdissection; mRNA Expression; neurobiological; neurobiological mechanism; neurokinin 1; neuronal; neuronal excitability; neurotransmitter release; neutralizing antibody; new therapeutic target; nociceptive; novel; pain behavior; patch clamp; pathway; protein blotting; protein expression; receptor; recurrent pancreatitis; response; sensory nerve; social role; voltage",Molecular Mechanisms of Pain in Chronic Pancreatitis,,73558,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,4,314715,
7760540,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK073917-03,,NIDDK:357638;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"WANG, DAVID Q;",2110780;,5R01DK073917,01/15/2008,12/31/2011,"AKR/J Mouse; Accounting; Animal Welfare; Bibliography; CCK; CCK-8; Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-; Cell Communication and Signaling; Cell Signaling; Cholecystokinin; Cholecystokinin Octapeptide; Cholecystokinin Pancreozymin C-Terminal Octapeptide; Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholesterol; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Congenic Mice; Country; Crystallization; Data; Defect; Diet; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Factor; Environmental Impact; Environmental Risk Factor; Equipment; Ethics Committees, Research; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gall Bladder; Gall Bladder Emptying; Gallbladder; Gallbladder / Biliar; Gallbladder Calculus; Gallbladder Emptying; Gallbladder Stone; Gallbladder/Biliary system; Gallstones; Gastrointestinal Tract, Gall Bladder; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic Intervention; Genetic Techniques; Genetic defect; Genotype; H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2; Human; Human, General; IACUC; IRBs; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention, Genetic; Intracellular Communication and Signaling; Knockout Mice; Laboratories; Lentivirinae; Lentivirus; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Congenic; Mice, Knock-out; Mice, Knockout; Molecular Biology, Gene Therapy; Molecular Genetic; Molecular Genetics; Mouse Strains; Murine; Mus; Mutate; Mutation; Null Mouse; OP-CCK; Pancreozymin; Patients; Phenotype; Play; Predisposition; Predisposition gene; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Published Comment; QTL; Quantitative Trait Loci; Receptor Gene; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resistance; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Sincalide; Structure; Subfamily lentivirinae; Susceptibility; Susceptibility Gene; Technics, Genetic; Therapy, DNA; Uropancreozymin; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Virus-Lenti; abstracting; base; biological signal transduction; cholelith; dysmotility; dysmotility syndrome; environmental risk; expiration; gene therapy; genetic determinant; genetic therapy; genome mutation; genome, mouse; human subject; motility disorder; mouse genome; predisposing gene; prevent; preventing; programs; receptor; resistant; response; social role; vertebrata",The Role of Dysfunctional CCK-1R in Cholelithogenesis,,73917,HBPP,Hepatobiliary Pathophysiology Study Section,,3,357638,
7750571,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK073936-04,,NIDDK:245921;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TALLAHASSEE,UNITED STATES,PSYCHOLOGY,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"ECKEL, LISA A;",6715842;,5R01DK073936,01/01/2007,12/31/2011,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT Receptors; 5-HT(2C) Receptor; 5-HT2C Receptor; 5-Hydroxytryptamine; 5-Hydroxytryptamine Receptors; 5-Hydroxytryptamine Type 2C Receptors; 5HT; Accounting; Acute; Affect; Agonist; Animals; Anorectic Drug; Anorectic agent; Anorectics; Anorexia Nervosa; Anorexiant; Anorexic Drugs; Anorexient Agent; Anorexient Drug; Anorexigenic Drugs; Anti-Estrogens; Antidiabetic Hormone; Antiestrogens; Appetite; Appetite Depressants; Appetite Suppressants; Appetite-Depressing Drugs; Appetite-Suppressant Drugs; Aquadiol; Assay; Automobile Driving; Behavior; Behavioral; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain region; Bulimia; Bulimias; CCK; Cancer of Breast; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Chemotherapy-Hormones/Steroids; Cholecystokinin; Common Rat Strains; Complex; DRN; Data; Desire for food; Development; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Drivings, Automobile; Eating; Eating Disorders; Elements; Encephalon; Encephalons; Endocrine Gland Secretion; Enteramine; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptors; Estrus; Event; Female; Fenfluramine; Food Intake; GCG; Genes; Glucagon; Glucagon (1-29); Glukagon; Goals; HG-Factor; Hippophaine; Hormones; Human; Human, General; Hyperglycemic-Glycogenolytic Factor; Hyperphagia; Hypothalamic structure; Hypothalamus; Hypothalamus, Medial; Hypothalamus, Middle; ICI 182,780; ICI 182780; Injection of therapeutic agent; Injections; Intermediate Hypothalamic Region; Intracellular Communication and Signaling; Investigators; Laboratories; Link; Location; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Mesencephalon; Methods and Techniques; Methods, Other; Microdialysis; Microinjections; Mid-brain; Midbrain; Midbrain structure; Middle Hypothalamus; Modeling; Molecular; Molecular Genetic; Molecular Genetics; NRVS-SYS; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervosa, Bulimia; Nervosas, Anorexia; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuronal Transmission; Neurons; Neurosciences; Neurotransmitters; Nucleus; Ovarian; Ovarian hormone; Overeating; Ovocyclin; Ovocylin; Pancreozymin; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Peptides; Peripheral; Physiologic; Physiological; Play; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Preoptic Areas; Prevalence; Progynon; Rat; Rattus; Receptor Protein; Receptor, Serotonin, 5-HT2C; Research; Research Personnel; Researchers; Risk Factors; Rodent; Rodentia; Rodentias; Role; Satiation; Satiations; Serotonin; Serotonin 2C Receptor; Sex Characteristics; Sex Differences; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure of paraventricular nucleus; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic Estradiol; Therapeutic Hormone; Therapeutic Steroid Hormone; Tissues; Uropancreozymin; Weight Gain; Weight Increase; Woman; Work; anorexic agent; antiestrogen; antiestrogenic; base; biological signal transduction; body weight gain; body weight increase; clinical relevance; clinically relevant; disease/disorder; dorsal raphe nucleus; driving; estrogen inhibitor; estrogenic activity; estrous; extracellular; feeding; gender difference; hypothalamic; in vivo; inhibitor; inhibitor/antagonist; malignant breast neoplasm; men; men's; neural; neurobiological mechanism; neuronal; neurotransmission; paraventricular nucleus; polyphagia; post-menopausal; postmenopausal; postsynaptic; preoptic region; presynaptic; receptor; relating to nervous system; reuptake; satiety; serotonin receptor; sexual dimorphism (noncellular); social role; steroid hormone; transcription factor; wt gain",Hormone-neurotransmitter interactions in the control of food intake.,,73936,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,4,245921,
7766943,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK074046-03,,NIDDK:329997;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,,08,623216371,US,NY,10019,ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS,"GELIEBTER, ALLAN ;",1959801;,5R01DK074046,09/01/2007,12/31/2012,"1-Propanone, 2-methyl-1,2-di-3-pyridinyl-; Acute; Aeroseb-HC; Air; Appetite; Appetite Disorder; Appetite Regulation; Appetite stimulated; Area; Behavior; Behavioral; Binge Eating; Binge eating disorder; Biological; Biological Factors; Blood Plasma; Body Composition; Body Weight; Body fat; Bulimia; Bulimias; CCK; Caloric Intake; Categories; Cetacort; Chemotherapy-Hormones/Steroids; Cholecystokinin; Clinical Research; Clinical Study; Comparative Study; Consumption; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Cross-Over Studies; Cross-Over Trials; Crossover Studies; Crossover Trials; D-Glucose; Depression; Dermacort; Desire for food; Dextrose; Diagnostic; Disease; Disinhibition; Disorder; Distress; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; Dysfunction; Eating; Eating Behavior; Eating Disorders; Eldecort; Endocrine Gland Secretion; Endocrinology; Energy Intake; Exhibits; Factor, Biologic; Factors, Psychological; Fasting; Fats; Fatty acid glycerol esters; Food; Food Intake; Functional disorder; GLP-1; Gastric Emptying; Gastric Emptyings; Gender; Glucose; Height; Hormones; Hour; Human; Human, General; Humulin R; Hunger; Hydrocortisone; Hydrocortone; Hytone; Increased food appetite; Individual; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intake; Intervention; Intervention Strategies; Investigators; Laboratories; Lead; Leptin; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Mental Depression; Metabolism and Endocrinology; Methbipyranone; Methods; Methopyrapone; Metyrapone; Modeling; NIDDK; NIH; NMR Imaging; NMR Tomography; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Nervosa, Bulimia; Novolin R; Nuclear Magnetic Resonance Imaging; Nutracort; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; PBO; Pancreozymin; Pattern; Pb element; Peptides; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Physiopathology; Placebo Control; Placebos; Plasma; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Principal Investigator; Proctocort; Production; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychological Factors; Psychology; Questionnaires; Reporting; Research Personnel; Researchers; Residual; Residual state; Reticuloendothelial System, Serum, Plasma; Satiation; Satiations; Science; Serum, Plasma; Sham Treatment; Stress; Testing; Therapeutic Hormone; Therapeutic Hydrocortisone; United States National Institutes of Health; Uropancreozymin; Visceral; Weight; Zeugmatography; adiposity; anorexigenic peptide; base; behavioral disinhibition; biological adaptation to stress; blind; caloric dietary content; compulsive eating; compulsive feeding; compulsive overeating; corpulence; corpulency; corpulentia; disease/disorder; drug/agent; emotional eating; falls; fasted; fasts; ghrelin; glucagon-like peptide 1; heavy metal Pb; heavy metal lead; improved; increased appetite; increased hunger; interest; interventional strategy; men; men's; ob/ob mouse; obese; obese people; obese person; obese population; obesity risk; pathophysiology; placebo controlled study; placebo controlled trial; prevent; preventing; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; programs; psychologic; psychological; purge; purging; reaction; crisis; response; restraint; satiety; sham therapy; social; social stress; stomach emptying; stress response; stress; reaction; stressor; subcutaneous",Appetite Hormones in Binge Eating Disorder,,74046,APDA,Adult Psychopathology and Disorders of Aging Study Section,,3,329997,
7760611,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK074270-05,,NIDDK:260115;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAMPAIGN,UNITED STATES,ANATOMY/CELL BIOLOGY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"FREEMAN, BRIAN C;",1894228;,5R01DK074270,02/01/2006,01/31/2011,"ATP phosphohydrolase; ATPase; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Assay; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Blood Pressure, High; Cancers; Cell Communication and Signaling; Cell Signaling; Cells; Chaperone; Chemotherapy-Hormones/Steroids; Complex; DNA Binding; DNA Binding Interaction; DNA-Dependent RNA Polymerase II; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Defect; Disease; Disorder; Dissociation; EC 2.7.7.6; Endocrine Gland Secretion; Engineering; Engineerings; Equilibrium; Esthesia; Event; Fluorescence; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genetic Transcription; Genomics; Goals; Health; Hormone Receptor; Hormones; Hypertension; INFLM; In Vitro; Inflammation; Intracellular Communication and Signaling; Kinetic; Kinetics; Lead; Life; Ligands; Malignant Neoplasms; Malignant Tumor; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Molecular; Molecular Chaperones; Molecular Interaction; Monitor; Nuclear; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Pathway interactions; Pb element; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA Polymerases; RNA, Messenger; Reaction Time; Receptor Protein; Receptor Signaling; Recruitment Activity; Regulation; Response Elements; Response RT; Response Time; Role; Run-On Assays; Sensation; Series; Signal Transduction; Signal Transduction Systems; Signaling; Structure; TFIIF; Testing; Therapeutic Agents; Therapeutic Hormone; Transcript; Transcription; Transcription, Genetic; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Withdrawal; balance; balance function; biological signal transduction; cofactor; disease/disorder; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; insight; mRNA; malignancy; mutant; neoplasm/cancer; pathway; psychomotor reaction time; receptor; recruit; research study; response; scaffold; scaffolding; social role; transcription factor; transcription factor TFIIF",Dynamic signaling by intracellular hormone receptors,,74270,MCE,Molecular and Cellular Endocrinology Study Section,,5,260115,
7725826,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK074398-04,,NIDDK:313558;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MOSTOV, KEITH E.;",1880444;,5R01DK074398,01/01/2007,11/30/2010,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 2-dimensional; 3-D; 3-Dimensional; 4-Hydroxy-Tamoxifen; 4-dimensional; 4-hydroxytamoxifen; 4-monohydroxytamoxifen; Abbreviations; Acute Kidney Failure; Acute Kidney Tubular Necrosis; Acute Renal Failure with Tubular Necrosis; Affect; Antimorphic mutation; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; Cell surface; Cell-Extracellular Matrix; CellLine; Cells; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Collagen; Complex; Conditioned Culture Media; Conditioned Medium; Confocal Microscopy; Culture Media, Conditioned; Cyst; Defect; Development; Disease; Disorder; Dogs; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Doxycycline; EC 2.7; EC 2.7.2-; ECM; Epithelial; Epithelial Cells; Estrogen Receptor 1; Extracellular Matrix; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; Family; Fibrosis; Four-dimensional; GAP Proteins; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GFAC; GTP GDP exchange factor; GTP Phosphohydrolases; GTPase-Activating Proteins; GTPases; Gel; Genes; Genetic Condition; Genetic Diseases; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; HGF/SF; Health; Hepatocyte Growth Factor; Hepatopoietin; Hepatopoietin A; Hereditary Disease; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Injury; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigators; Kidney; Kidney Diseases; Kidney Failure, Acute; Kidney Insufficiency, Acute; Kidney Tubular Necrosis, Acute; Kidney Tubules; Kinases; Kinetic; Kinetics; Learning; Lipid Rafts, Cell Membrane; Lower Nephron Nephrosis; Lung Fibroblast-Derived Mitogen; Lymphokines and Cytokines, scatter factor; MAP Kinase Cascades; MAP Kinase Gene; MAP Kinase Modules; MAP Kinase Signaling Cascades; MAP kinase; MAPK; MEBCD cpd; MMPs; Mammals, Dogs; Matrix Metalloproteinases; Membrane Microdomains; Mesenchymal; Micro-tubule; Microscopy, Confocal; Microscopy, Video; Microtubules; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinases; Model System; Models, Biologic; Molecular; Molecular Disease; Molecular Interaction; Myosin Light Chains; Natural regeneration; Nephropathy; Occluding Junctions; Organ; PI(3,4)P2; PI(3,4,5)P3; PTK Receptors; Pathway interactions; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphotransferases; Physiologic; Physiological; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; PtdIns; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RTK; Ras/Raf; Receptor Protein-Tyrosine Kinases; Recovery; Regeneration; Renal Cell; Renal Disease; Renal Failure, Acute; Renal Insufficiency, Acute; Renal tubule structure; Research Personnel; Researchers; Rho-associated kinase; Rho-kinase; Role; Scatter Factor; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Staging; System; System, LOINC Axis 4; Testing; Thick; Thickness; Tight Junctions; Time; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Tube; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Urinary System, Kidney; Vibramycin; Video Microscopy; Videomicrography; Videomicroscopy; Work; Zonula Occludens; acute tubular necrosis; alpha-6-Deoxyoxytetracycline; biological signal transduction; canine; cell type; cultured cell line; disease/disorder; domestic dog; exchange factor; genetic disorder; guanosinetriphosphatase; guanosinetriphosphatase activating protein; hereditary disorder; in vivo; kidney cell; kidney development; kidney disorder; lipid raft; meetings; methyl-beta-cyclodextrin; monolayer; nephrogenesis; para-hydroxytamoxifen; pathway; phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,; phosphoinositide-3,4,5-triphosphate; phosphoinositide-3,4-bisphosphate; prevent; preventing; programs; regenerate; renal; renal disorder; renal tubule; rho; shRNA; short hairpin RNA; small hairpin RNA; social role; stem; tamoxifen metabolite B; time use; two-dimensional",Mechanisms of Renal Tubulogenesis,,74398,CMBK,Cellular and Molecular Biology of the Kidney Study Section,,4,313558,
7752799,R01,DK,5,,01/01/2010,12/31/2010,,5R01DK074500-04,,NIDDK:298282;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"TURLEY, SHANNON J;",1906250;,5R01DK074500,01/01/2007,12/31/2011,"ATGN; Affect; Antigens; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Responses; Autoimmune Status; Autoimmunity; Autologous Antigens; B9 endocrine pancreas; Blood leukocyte; Body Tissues; CD8; CD8B; CD8B1; CD8B1 gene; Celiac Disease; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Common Rat Strains; Dendritic Cells; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diathesis; Disease; Disease susceptibility; Disorder; Dysfunction; Endocrine; Enteral; Enteric; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epithelium, Intestinal; Exhibits; Functional disorder; Gastrointestinal Tract, Pancreas; Glutaminyl-Peptide Gamma-Glutamyltransferases; Glutelin; Gluten; Gluten Enteropathy; Gluten-Sensitive Enteropathy; Goals; Gut Epithelium; Gut Inflammation; HTRPY; High Prevalence; Histocompatibility Complex; Histocompatibility Complices; Humulin R; Hyperplasia; Hyperplastic; Hypertrophy; IDD; IDDM; INFLM; Immune response; Inbred NOD Mice; Inflammation; Inflammatory Diseases of the Intestinal Tract; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intestinal; Intestinal Inflammation; Intestines; Invaded; Islands of Langerhans; Islet Cells; Islets of Langerhans; LYT3; Lead; Lesion; Leukocytes; Link; Lymph node proper; Major Histocompatibility Complex; Major Histocompatibility Complices; Mammals, Rats; Marrow leukocyte; Mediating; Mice, Inbred NOD; Molecular; Monitor; Mouse, NOD; Nesidioblasts; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathogenesis; Patients; Pb element; Peptides; Permeability; Physiopathology; Prevention strategy; Preventive strategy; Process; Protein-Glutamine gamma-Glutamyltransferases; Protein-glutamine[{..}]amine gamma-glutamyltransferase; Proteins; Rat; Rattus; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Lymph Node; Role; Self-Antigens; Sprue, Celiac; Sprue, Nontropical; Staging; Stimulus; Structure of intestinal epithelium; Subcellular Process; T-Cells; T-Lymphocyte; T1 diabetes; T1D; T1DM; Testing; Thymus-Dependent Lymphocytes; Tissues; Transglutaminases; Type 1 diabetes; Veiled Cells; Wheat; White Blood Cells; White Cell; Work; autoimmune antibody; autoimmune disorder; base; beta cell development; bowel; diabetes; disease/disorder; disease/disorder proneness/risk; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; gastrointestinal; gastrointestinal epithelium; gene product; heavy metal Pb; heavy metal lead; host response; idiopathic steatorrhea; immunogen; immunoresponse; insight; insulin dependent diabetes; intestinal epithelium; intestinal villi; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; liability to disease; lymph gland; lymph nodes; pathophysiology; research study; response; self reactive antibody; self recognition (immune); social role; thymus derived lymphocyte; type I diabetes; white blood cell; white blood corpuscle",Role of the gut epithelium in pancreatic autoimmunity,,74500,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,4,298282,
7713989,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK074652-03,,NIDDK:328185;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DURHAM,UNITED STATES,PHARMACOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"MCDONNELL, DONALD P;",1867637;,5R01DK074652,12/20/2007,11/30/2012,"Activation, Gene; Address; Adopted; Affinity; Agonist; Agreement; Animal Model; Animal Models and Related Studies; Animal Welfare; Anti-Estrogens; Antiestrogens; Bibliography; Biogenesis; Biology; Boxing; Breast Cancer Cell; Breast Neoplasms; Breast Tumors; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Respiration; Cell Signaling; Cell model; CellLine; Cells; Cellular Respiration; Cellular model; Citric Acid Cycle; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; Data; Data Set; Dataset; Disease Outcome; Drugs; Dysfunction; ERBB2; ERBB2 gene; Ecological impact; Editorial Comment; Editorial Comment (PT); Engineering; Engineerings; Environment; Environmental Impact; Enzymes; Epithelial Cells; Equipment; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethics Committees, Research; Family; Forecast of outcome; Functional disorder; Gene Activation; Gene Expression; Gene Expression Profile; Gene Targeting; Generations; Genes; Genes, HER-2; Genes, HER2; Genes, erbB-2; Genes, neu; Goals; Grant; HER -2; HER-2; HER2; HER2/neu; Human; Human Breast Cancer Cell; Human EGF Receptor 2 Gene; Human, General; IACUC; IRBs; Impact evaluation; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Intention; Intermediary Metabolism; International; Intracellular Communication and Signaling; Investigators; Krebs Cycle; Lead; Left; Ligand Binding; Ligands; Link; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; METBL; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Cancer; Mammary Glands, Human; Mammary Neoplasms; Mammary gland; Man (Taxonomy); Man, Modern; Medication; Metabolic Pathway; Metabolic Processes; Metabolism; Mitochondria; Modeling; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Nuclear Receptors; Origin of Life; Orphan; Outcome; Paper; Pathway interactions; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiopathology; Principal Investigator; Process; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; Published Comment; Publishing; RNA, Small Interfering; Receptor Protein; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Stream; Suggestion; Surface; TCA cycle; TKR1; Targetings, Gene; Technology; Testing; Therapeutic Estrogen; Time; Tricarboxylic Acid Cycle; Tumor Pathology; Validation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; aerobic metabolism; aerobic respiration; antiestrogen; antiestrogenic; base; biological signal transduction; c-erbB-2; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; cofactor; combinatorial; conformation; conformational state; cultured cell line; drug/agent; estrogen inhibitor; estrogen-related receptor; experiment; experimental research; experimental study; expiration; fatty acid oxidation; gene expression signature; gene product; heavy metal Pb; heavy metal lead; human subject; malignancy; malignant breast neoplasm; mammary; mammary tumor; meetings; mitochondrial; model organism; mutant; neoplasm/cancer; outcome forecast; overexpression; oxidative metabolism; pathophysiology; pathway; programs; receptor; receptor function; research study; response; siRNA; social role; success; therapeutic target; transcriptome; tumor; vertebrata",Validation of the Estrogen Related Receptor as a therapeutic target in cancer,,74652,MCE,Molecular and Cellular Endocrinology Study Section,,3,328185,
7745518,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK074778-05,,NIDDK:393533;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"SHIRIHAI, ORIAN S;",7039665;,5R01DK074778,02/01/2007,11/30/2011,"ATP Synthesis; ATP Synthesis Pathway; Active Oxygen; Acute; Address; Affect; Animal Model; Animal Models and Related Studies; Animals; Antioxidants; Apoptosis; Apoptosis Pathway; Apoptotic; Appearance; Autophagocytosis; B blood cells; B-Cells; B-Lymphocytes; Behavior; Beta Cell; Bioenergetic; Bioenergetics; Blood Coagulation Factor IV; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C57BL/6 Mouse; Ca++ element; Calcium; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell model; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular model; Chimera Protein; Chimeric Proteins; Chronic; Coagulation Factor IV; Common Rat Strains; Communication; Coupling; D-Glucose; Data; Deterioration; Development; Dextrose; Diabetes Mellitus; Diabetic Diet; Diet; Diffusion; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; EFF; Environment; Environmental Factor; Environmental Risk Factor; Equilibrium; Event; Exposure to; Factor IV; Fats; Fatty acid glycerol esters; Frequencies (time pattern); Frequency; Functional disorder; Fusion Protein; GCG; GCG gene; GLP1; GLP2; GRPP; Generations; Genes; Glucose; Goals; In Vitro; Individual; Insulin Cell; Insulin Secreting Cell; Internet; Intracellular Communication and Signaling; Investigators; Ions; Label; Lipids; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Mediator; Mediator of Activation; Mediator of activation protein; Membrane Potentials; Metabolic; Metabolic Pathway; Metabolic syndrome; Methods; Mice; Mitochondria; Modeling; Monitor; Murine; Mus; Nature; Nutrient; Nutrition; Nutritional Science; Obesity; Oxygen Radicals; Pathway interactions; Performance; Physiologic; Physiological; Physiopathology; Play; Population; Pro-Oxidants; Programs (PT); Programs [Publication Type]; Proteins; Quality Control; Racial Segregation; Rat; Rats, Zucker; Rattus; Reactive Oxygen Species; Regulation; Relative; Relative (related person); Reporting; Research Personnel; Research Resources; Researchers; Resistance; Resources; Resting Potentials; Role; Science of nutrition; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stimulus; Subcellular Process; Testing; Titrations; Transmembrane Potentials; Transmission; WWW; Zucker Rats; adiposity; anti-oxidant; autophagy; balance; balance function; biological signal transduction; cell type; corpulence; corpulency; corpulentia; diabetes; diabetes nutrition; diabetic; disease/disorder; effusion; environmental risk; gene product; glucose metabolism; in vivo; insulin secretion; mitochondrial; model organism; non-diabetic; nondiabetic; novel; nutrition; obese; obese people; obese person; obese population; pathophysiology; pathway; prevent; preventing; programs; protein expression; repair; repaired; resistant; response; segregation; social role; transmission process; web; world wide web",Mitochondrial dynamics in beta cell function and dysfunction,,74778,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,5,393533,
7770774,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK074825-02,,NIDDK:340956;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,GREENVILLE,UNITED STATES,MISCELLANEOUS,03,607579018,US,NC,27858,EAST CAROLINA UNIVERSITY,"NEUFER, P. DARRELL;",1918762;,5R01DK074825,02/16/2009,01/31/2014,"Acute; Address; Affect; Antioxidants; Autoregulation; Bioenergetic; Bioenergetics; Buffers; Caloric Intake; Caloric Restriction; Carbohydrates; Causality; Cell Function; Cell Process; Cell Respiration; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Respiration; Chronic; Clinical; Common Rat Strains; Consumption; Coupled; Data; Depressed mood; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Dietary Fats; Diffuse; Dysfunction; Electron Transport; Electrons; Employee Strikes; Energy Intake; Energy Supply; Environment; Epidemic; Equilibrium; Etiology; Fats; Fatty acid glycerol esters; Ferricytochrome c; Ferrocytochrome c; Functional disorder; Gene Expression; Generations; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; H2O2; Health; Homeostasis; Human; Human, General; Humulin R; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; IPO-B; In Situ; In Vitro; Individual; Inner mitochondrial membrane; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intake; Interphase Cell; Lead; Life Style; Lifestyle; Link; Lipids; MMC; MNSOD; MODY; Mammals, Rats; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measures; Membrane Potentials; Metabolic; Metabolic Diseases; Metabolic Disorder; Mitochondria; Mitochondrial Matrix; Mitochondrial Superoxide Dismutase; Mitochondrial Superoxide Dismutase 2; Mn Superoxide Dismutase; Morphology; Muscle; Muscle Fibers; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Myotubes; NIDDM; Negative Beta Particle; Negatrons; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-dividing Cell; Novolin R; Nutrition; Nutritional; Nutritional Science; O element; O2 element; Obesity; Organelles; Over weight; Overweight; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidizing Agents; Oxygen; Patients; Pb element; Peptides; Physical activity; Physiological Homeostasis; Physiopathology; Play; Predisposition; Pressure; Pressure- physical agent; Preventive; Process; Production; Rat; Rattus; Redox; Reducing Agents; Reductants; Regulation; Research; Respiration; Respiratory physiology; Resting Cell; Resting Potentials; Rhabdomyocyte; Role; SOD2 protein; SOD2 protein, human; Science of nutrition; Signaling Protein; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Strikes; Strikes, Employee; Subcellular Process; Superoxide Anion; Superoxide Dismutase 2; Superoxide Radical; Superoxides; Supply, Energy; Susceptibility; System; System, LOINC Axis 4; T2D; T2DM; Thesaurismosis; Transmembrane Potentials; Type 2 diabetes; Type II diabetes; Uncoupling Agents; Weight Gain; Weight Increase; adiposity; adult onset diabetes; adult youth; aerobic metabolism; aerobic respiration; anti-oxidant; balance; balance function; base; body weight gain; body weight increase; caloric dietary content; calorie restriction; corpulence; corpulency; corpulentia; cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; cytochrome c; depressed; diabetes; diabetic patient; dietary lipid; disease causation; disease etiology; disease/disorder etiology; disorder etiology; electron acceptor; electron transfer; energy balance; gain of function; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; heavy metal Pb; heavy metal lead; high risk; human SOD2 protein; insulin resistant; insulin sensitivity; ketosis resistant diabetes; loss of function; lung function; maturity onset diabetes; metabolism disorder; mitochondrial; mitochondrial dysfunction; mitochondrial megachannel; mitochondrial permeability transition pore; new approaches; novel; novel approaches; novel strategies; novel strategy; nutrition; obese; obese people; obese person; obese population; oxidation reduction reaction; oxidative metabolism; pathophysiology; pressure; prevent; preventing; public health relevance; respiratory function; respiratory mechanism; response; sadness; sedentary; social role; wt gain; young adult",Linking Mitochondrial Bioenergetics to Muscle Insulin Sensitivity," This research seeks to identify the mechanism(s) by which metabolic imbalance caused by over nutrition and physical inactivity leads to altered mitochondrial function and insulin resistance in skeletal muscle of humans. This is highly significant, as a fundamental understanding of the causes of insulin resistance is necessary in order to devise adequate preventive measures and treatments to reduce the health and financial impact of the obesity and diabetes epidemics.",74825,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,,2,340956,
7754702,R01,DK,5,,01/01/2010,12/31/2010,PA-04-074,5R01DK074876-04,,NIDDK:476574;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,AMHERST,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,153926712,US,MA,010039242,UNIVERSITY OF MASSACHUSETTS AMHERST,"CHASAN-TABER, LISA ;",1938261;,5R01DK074876,01/15/2007,12/31/2011,"ACOG; ACRP30 protein; Accounting; Acute; Adoption; American College of Obstetricians and Gynecologists; Apgar Score; Behavior; Birth; Blood Serum; C-reactive protein; Cardiovascular Diseases; Chronic; Collaborations; D-Glucose; Development; Dextrose; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Gestational; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes, Gestational; Diabetes, Pregnancy-Induced; Diagnosis; Discipline; Disease; Disorder; Economics; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethnic and Racial Minorities; Exercise; Exercise, Physical; Fasting; Follow-Up Studies; Followup Studies; Gestation; Gestational Diabetes; Glucose; Goals; Guidelines; Health; High Risk Woman; History; Humulin R; Infant; Institute of Medicine; Institute of Medicine (U.S.); Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intervention; Intervention Strategies; Investigators; Knowledge; Leptin; Life Style; Lifestyle; Low Birth Weight Infant; MODY; Maintenance; Maintenances; Maturity-Onset Diabetes Mellitus; Measures; Minority Groups; Modality; Morbidity; Morbidity - disease rate; NAS/IOM; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Outcome; Parturition; Patients; Physical activity; Population; Pregnancy; Pregnant Women; Prenatal care; Preparedness; Programs (PT); Programs [Publication Type]; Proteins, specific or class, C-reactive; Protocol; Protocols documentation; Randomized; Readiness; Recording of previous events; Recruitment Activity; Recurrence; Recurrent; Research Personnel; Researchers; Risk; Risk Factors; Scientist; Serum; Staging; T2D; T2DM; Testing; Translating; Translatings; Type 2 diabetes; Type II diabetes; Underrepresented Minority; United States; VLBW (human); Walking; Weight Gain; Weight Increase; Woman; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adiponectin; adiposity; adult onset diabetes; apM-1 protein; apM1 (adipose-specific) protein; biomarker; body weight gain; body weight increase; cardiovascular disorder; clinical practice; corpulence; corpulency; corpulentia; diabetes of pregnancy; disease/disorder; experience; fasted; fasting plasma glucose; fasts; glucose tolerance; glycemic control; improved; infant outcome; innovate; innovation; innovative; insulin resistant; intervention design; intervention program; interventional strategy; ketosis resistant diabetes; language translation; low birth weight infant human; low birthweight; maturity onset diabetes; modifiable risk; novel; ob/ob mouse; obese; obese people; obese person; obese population; prevent; preventing; programs; racial and ethnic; racial/ethnic; randomisation; randomization; randomly assigned; recruit; resistin; social; social cognitive theory; socioeconomic; socioeconomically; socioeconomics; theories; therapy design; tool; treatment design; under-represented minority; underserved minority; women at high risk; wt gain",An Exercise Intervention to Prevent Recurrent GDM,,74876,PRDP,Psychosocial Risk and Disease Prevention Study Section,,4,476574,
7766257,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK074932-04,,NIDDK:264865;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,PATHOLOGY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"HUI, DAVID Y;",1872931;,5R01DK074932,04/01/2007,01/31/2011,"A Mouse; APOE [{C0003595}]; Adipocytes; Adipose Cell; Adipose tissue; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apo-E; ApoE; Apolipoprotein E; Attention; Blood Circulation; Blood Plasma; Bloodstream; Body Tissues; Caloric Intake; Calories; Carbohydrates; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cells; Characteristics; Chronic; Circulation; Consumption; D-Glucose; DAG lipase; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Deposit; Deposition; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diacylglycerol Lipase; Diet; Dietary Factors; Dietary Sucrose; Diglyceride Lipase; Energy Expenditure; Energy Intake; Energy Metabolism; Equilibrium; Essential Fatty Acids; Expenditure; Family member; Fat Cells; Fats; Fatty Acids; Fatty Acids, Essential; Fatty Tissue; Fatty acid glycerol esters; Glucose; HDL; Heart; Heavy Lipoproteins; Heparin-Clearing Factor; High Density Lipoproteins; High density lipoprotein; Humulin R; Hydrolysis; Hyperglycemia; INFLM; Inflammation; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intake; Investigators; Knock-out; Knockout; Knockout Mice; LDL-Receptor Related Proteins; LPL; Lipase; Lipemia-Clearing Factor; Lipid Trafficking; Lipids; Lipocytes; Lipoprotein Binding; Lipoprotein LDL Receptors; Lipoprotein Receptor; Lipoproteins; Lipoproteins, HDL; Literature; Liver; Low Density Lipoprotein Receptor; Low Density Lipoprotein-Related Proteins; MODY; Mammals, Mice; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mediating; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Fibers; Muscle Tissue; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Myocardium; Myocytes; Myotubes; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Obesity; Organ System, Cardiovascular; Oxidative Stress; Pathogenesis; Pathway interactions; Phenotype; Plasma; Play; Post-Heparin Lipase; Postheparin Lipase; Postheparin Lipoprotein Lipase; Predisposition; Primary Senile Degenerative Dementia; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Family; Proteins; Publishing; Receptor Protein; Receptors, LDL; Reporting; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Serum, Plasma; Rhabdomyocyte; Role; Saccharose; Serum, Plasma; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Source; Sucrose; Surface; Susceptibility; T2D; T2DM; Table Sugar; Testing; Tissues; Transgenes; Transgenic Mice; Transgenic Organisms; Triacylglycero-protein acylhydrolase; Triacylglycerol; Triacylglycerol Hydrolase; Triacylglycerol Lipase; Triacylglycerol acylhydrolase; Tributyrinase; Triglyceridase; Triglyceride Lipase; Triglycerides; Triolean Hydrolase; Type 2 diabetes; Type II diabetes; VLDL receptor; Vascular, Heart; Weight Gain; Weight Increase; Wild Type Mouse; adipose; adiposity; adult onset diabetes; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; alpha-Lipoproteins; apo E-3; apo E3; apoE-3; apoE3; apolipoprotein E-3; apolipoprotein E3; balance; balance function; base; body system, hepatic; body weight gain; body weight increase; caloric dietary content; calorie (nutrition); cardiac muscle; circulatory system; clearing factor lipase; corpulence; corpulency; corpulentia; dementia of the Alzheimer type; design; designing; diabetes; experiment; experimental research; experimental study; fat metabolism; feeding; gene product; glucose metabolism; heart muscle; hyperglycemic; insulin resistant; insulin sensitivity; ketosis resistant diabetes; lipid metabolism; lipid transport; lipoprotein lipase; liver-specific lipoprotein; maturity onset diabetes; member; new therapeutics; next generation therapeutics; novel therapeutics; obese; obese people; obese person; obese population; organ system, hepatic; particle; pathway; prevent; preventing; primary degenerative dementia; programs; receptor; receptor binding; receptor expression; receptor function; research study; resistant; response; senile dementia of the Alzheimer type; social role; transgenic; triacylglycerol protein acylhydrolase; tributyrase; uptake; very low density lipoprotein receptors; white adipose tissue; wt gain; yellow adipose tissue",Role of Lipoprotein Receptors in Diet-induced Obesity and Diabetes,,74932,ZRG1,Special Emphasis Panel,,4,264865,
7754876,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK074979-03,,NIDDK:351945;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,NONE,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"OBIN, MARTIN S;",1977448;,5R01DK074979,01/10/2008,12/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adipocytes; Adipose Cell; Adipose tissue; Analysis, Data; Animal Welfare; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Applications Grants; Atypical Adipocyte; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bibliography; Biological; Bone Marrow Transplant; Bone Marrow Transplantation; CAP4 protease; CASP8 Protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cancers; Cardiovascular Diseases; Caspase-8/Flice; Cell Communication and Signaling; Cell Count; Cell Death; Cell Death, Programmed; Cell Number; Cell Signaling; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chronic; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Country; Critiques; DIF; Data; Data Analyses; Death; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Differentiation Factor, B-Cell; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Exhibits; FADD-Like ICE; FADD-homologous ICE/CED3-Like Protease; FLICE protein; Fat Cells; Fats; Fatty Tissue; Fatty acid glycerol esters; Figs; Figs - dietary; Frequencies (time pattern); Frequency; Gametes; Gene Expression; Germ Cells; Germ-Line Cells; Grafting, Bone Marrow; Grant Proposals; Grants, Applications; HIV; HPGF; HTLV-III; HTRPY; Hepatocyte-Stimulating Factor; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Hybridoma Growth Factor; Hyperplasia; Hyperplastic; Hypertrophy; IACUC; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; IRBs; Immune; Impact, Environmental; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intermediary Metabolism; International; Intracellular Communication and Signaling; Investigators; Italy; Knockout Mice; Knowledge; LAV-HTLV-III; Laboratories; Letters; Light; Lipids; Lipocytes; Lipodystrophy; Lipolysis; Literature; Lymphadenopathy-Associated Virus; MACH protein; METBL; MGI-2; MODY; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Mch5 protease; Measures; Metabolic; Metabolic Processes; Metabolic syndrome; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mice, Obese; Mice, Transgenic; Modeling; Morphology; Murine; Mus; Myeloid Differentiation-Inducing Protein; NIDDM; Necrosis; Necrotic; Non obese; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonobese; Null Mouse; Obese Mice; Obesity; Paper; Pathogenesis; Photoradiation; Plasmacytoma Growth Factor; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Rat; Rattus; Recruitment Activity; Reporting; Reproduction; Reproductive Cells; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Risk Factors; Role; SREBP-1a; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stroke; T2D; T2DM; TNF; TNF A; TNF Alpha; TNF gene; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2; TNFSF2 protein, human; Testing; Time; Transgenes; Transgenic Mice; Tumor Necrosis Factor; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Type 2 diabetes; Type II diabetes; Vascular Accident, Brain; Vertebrate Animals; Vertebrates; Virus-HIV; Visceral; abstracting; adipose; adiposity; adult onset diabetes; base; biological signal transduction; brain attack; cardiovascular disorder; caspase-8; cerebral vascular accident; corpulence; corpulency; corpulentia; cytokine; disease/disorder; experiment; experimental research; experimental study; expiration; feeding; human TNF protein; human data; human subject; improved; initial cell; insight; insulin resistant; insulin signaling; interferon beta 2; ketosis resistant diabetes; macrophage; male; malignancy; maturity onset diabetes; mouse model; necrocytosis; neoplasm/cancer; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; programs; recruit; research study; response; sexual cell; social role; stroke; subcutaneous; transgene expression; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; vertebrata; white adipose tissue; yellow adipose tissue",Adipocyte Death and Obesity-Induced Inflammation,,74979,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,3,351945,
7979889,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK074993-04,,NIDDK:289378;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"PIKE, J. WESLEY;",6616296;,5R01DK074993,01/15/2007,11/30/2011,"1,25-Dihydroxycholecalciferol Receptors; 1,25-Dihydroxyvitamin D3 Receptors; A Mouse; Animal Model; Animal Models and Related Studies; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Bone; Bone Marrow; Bone Resorption; Bone and Bones; Bone remodeling; Bones and Bone Tissue; CREB; CREB1; CREB1 gene; CSF-1; CSF1; Cells; Chemotherapy-Hormones/Steroids; Cholecalciferol Receptors; Chromatin; Colony-Stimulating Factor 1; Complex; DNA; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; DNA-Dependent RNA Polymerase II; Deoxyribonucleic Acid; Differentiation Factor, B-Cell; Dinoprostone; Disease; Disorder; Distal; Endocrine Gland Secretion; Enhancers; Equilibrium; Esocidae; Event; Functional RNA; Gene Expression; Gene Products, RNA; Gene Transcription; Genes; Genetic Transcription; HPGF; Hematopoietic; Hepatocyte-Stimulating Factor; Histones; Hormonal; Hormones; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; Immune Precipitation; Immunoprecipitation; In Vitro; Individual; Inflammatory; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; Investigators; Ligands; Lymphocyte-Stimulating Hormone; M-CSF; MCSF; MGI-2; Macrophage Cell Factor; Macrophage Colony-Stimulating Factor; Mammals, Mice; Measures; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Mice; Modification; Molecular; Molecular Interaction; Murine; Mus; Myeloid Differentiation-Inducing Protein; Nature; Non-Coding; Non-Coding RNA; Nucleic Acid Regulatory Sequences; ODF; OPGL; Osteoblasts; Osteoclastic Bone Loss; Osteoclasts; Osteolytic; Output; PGE2; PGE2 alpha; PGE2alpha; Pathologic; Physiologic; Physiological; Pike; Pike fish; Plasmacytoma Growth Factor; Play; Pol II; Preparation; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandins; Prostanoids; RANKL; RNA; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA, Messenger; RNA, Non-Polyadenylated; Receptors, 1,25-Dihydroxyvitamin D 3; Receptors, Calcitriol; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research Personnel; Researchers; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Role; STAT3; STAT3 gene; Scanning; Serum Calcium Level; Site; Structure; Supporting Cell; T Helper Factor; TNFSF11; TNFSF11 gene; Techniques; Testing; Therapeutic; Therapeutic Hormone; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; VDR; Vitamin D 3 Receptors; Vitamin D Receptors; Vitamin D3 Receptor; balance; balance function; bone; bone remodelling; cell type; chromatin modification; cofactor; cytokine; disease/disorder; genetic regulatory element; hRANKL2; histone modification; in vivo; inhibitor; inhibitor/antagonist; insight; interferon beta 2; lymphocyte activating factor; mRNA; mRNA Expression; model organism; mouse model; osteoclastogenesis; overexpression; programs; receptor binding; response; sOdf; social role; transcription factor",Molecular Mechanisms of RANKL Activation in Osteoblasts,,74993,SBDD,Skeletal Biology Development and Disease Study Section,,4,289378,
7743777,R01,DK,5,,12/01/2009,11/30/2010,,5R01DK075072-04,,NIDDK:297342;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SALT LAKE CITY,UNITED STATES,GENETICS,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"MURTAUGH, LEWIS C;",1942243;,5R01DK075072,02/15/2007,11/30/2011,"21+ years old; Acinar Cell; Aciner Cells; Acinus organ component; Address; Adult; Affect; Alimentary Canal; Anaplastic; Autoregulation; B9 endocrine pancreas; Beta Cell; Body Tissues; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancers; Cataloging; Catalogs; Catenin, Beta-1; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Clinical Research; Clinical Study; Development; Developmental Biology; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Digestive Tract; Disease; Disorder; Duct; Duct (organ) structure; Ductal; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endocrine; Enzymes; Epithelial Cells; Epithelium; Exhibits; Exocrine pancreas; Family member; Future; GI Tract; Gastrointestinal Tract; Gastrointestinal Tract, Pancreas; Gastrointestinal tract structure; Gene Deletion; Generalized Growth; Gland; Growth; Health; Homeostasis; Human; Human, Adult; Human, General; Humulin R; IDD; IDDM; In Vitro; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Islands of Langerhans; Islet Cells; Islets of Langerhans; Knock-out; Knockout; Label; Left; Maintenance; Maintenances; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Tumor; Malignant neoplasm of pancreas; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal; Mesenchymas; Mesenchyme; Metaplasia; Metaplastic Change; Mice; Modeling; Molecular Genetic; Molecular Genetics; Mother Cells; Murine; Mus; Natural regeneration; Nesidioblasts; Novolin R; Oncogenesis; Organ; Organ System; Organogenesis; PRO2286; Pancreas; Pancreas Cancer; Pancreas, Endocrine; Pancreatic; Pancreatic Cancer; Pancreatic Diseases; Pancreatic Disorder; Pancreatic Islets; Pancreatitis; Pars endocrina pancreatis; Pathway interactions; Phenotype; Physiological Homeostasis; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Recovery; Regeneration; Research; Research Personnel; Researchers; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; Testing; Therapeutic; Therapeutic Intervention; Tissue Growth; Tissues; To specify; Type 1 diabetes; Undifferentiated; Work; acinus; acute pancreatitis; adult human (21+); alimentary tract; beta catenin; beta cell development; biological signal transduction; body system; cell fate specification; cell growth; cell type; critical period; diabetes; digestive canal; disease/disorder; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; gene deletion mutation; gene product; human disease; in vivo; injury response; insight; insulin dependent diabetes; interest; intervention therapy; interventional strategy; islet; islet development; islet progenitor; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; malignancy; mutant; neoplasm/cancer; nestin; nestin protein; novel; ontogeny; pancreas development; pancreas disorder; pancreatic tumorigenesis; pathway; postnatal; precursor cell; prevent; preventing; progenitor; programs; regenerate; regenerative; research study; response to injury; social role; stem cell differentiation; tumorigenesis; type I diabetes",Wnt/beta-catenin signaling in exocrine pancreas developoment and regeneration,,75072,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,4,297342,
7758191,R01,DK,5,,02/01/2010,01/31/2011,PAR-06-479,5R01DK075294-03,,NIDDK:272448;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,PHYSIOLOGY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"GUO, HWAI-CHEN ;",1871181;,5R01DK075294,02/01/2008,01/31/2013,"Acetates; Alleles; Allelomorphs; Amino Acids; Aminoacetic Acid; Aspartylglucosamine Amidohydrolase; Aspartylglucosaminidase; Aspartylglucosaminuria; Aspartylglucosylaminase; Aspartylglucosylamine Deaspartylase; Aspartylglycosamine Amidohydrolase; Austin syndrome; Bicarbonates; Binding; Binding (Molecular Function); Biochemical; Carbohydrate Linkages; Central Nervous System; Clinical; Complex; Connective Tissue; Coupled; Crystallization; Defect; Development; Disease; Disorder; Drugs; Early treatment; Enzyme Precursors; Enzymes; FLR; Face; Failure (biologic function); Family; Foundations; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Glycine; Glycoprotein Degradation; Glycoprotein Degradation Pathway; Glycoproteins; Glycosylasparaginase; HCO3; Hereditary Disease; Human; Human, General; Hydrogen Carbonates; Hydrolase; Hydrolysis; Investigators; Ions; L-Threonine; Lesion; Link; Linkages, Carbohydrate; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; Lysosomes; Man (Taxonomy); Man, Modern; Medication; Mental Retardation; Metabolic; Metabolic Diseases; Metabolic Disorder; Methods; Molecular; Molecular Disease; Molecular Interaction; Mucosulfatidoses; Mucosulfatidosis; Mutation; N(4)-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine amidohydrolase; N-terminal; NH2-terminal; Names; Neonatal Screening; Nervous System, CNS; Neuraxis; Newborn Infant Screening; Oligosaccharides; Pathogenesis; Patients; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Proenzymes; Programs (PT); Programs [Publication Type]; Proteins; Publishing; Reporting; Research Personnel; Researchers; Resolution; Site; Solid; Solvents; Structure; Surface; Symptoms; Therapeutic; Thesaurismosis; Threonine; Variant; Variation; Zymogens; aminoacid; aspartylglucosamidase (AGA) deficiency; aspartylglucosamidase deficiency; aspartylglucosaminuria (AGU); aspartylglycosaminuria; base; cell type; design; designing; disease/disorder; drug/agent; facial; failure; functional group; gene product; genetic disorder; genome mutation; glycoasparagines; hereditary disorder; inborn lysosomal enzyme disorder; inhibitor; inhibitor/antagonist; juvenile sulfatidosis; metabolism disorder; multiple sulfatase deficiency; multiple sulfatase deficiency (MSD); multiple sulphatase deficiency disease; mutant; newborn screening; prevent; preventing; programs; progressive neurodegeneration; protein structure; skeletal abnormality; small molecule",Structure-Based Design of Small Molecules for Aspartylglucosaminuria,,75294,ZRG1,Special Emphasis Panel,,3,272448,
7743101,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK075801-03,,NIDDK:316770;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DAVIS,UNITED STATES,BIOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"BODINE, SUE C;FURLOW, J DAVID (contact);",1923416 (contact);8029146;,5R01DK075801,01/01/2008,11/30/2011,"ADRGND; Adrenal Glands; Adrenals; Adrenergic Agonists; Adrenergic Receptor Agonist; Adrenomimetics; Adverse effects; Aging; Animal Welfare; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Assay; Atrophic; Atrophy; Atrophy, Muscle; Base Pairing; Benzenemethanol, 4-amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)-; Bibliography; Bioassay; Biologic Assays; Biological Assay; Bone; Bone and Bones; Bones and Bone Tissue; CHIP assay; Cachexia; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Cells; ChIP (chromatin immunoprecipitation); Chemotherapy-Hormones/Steroids; Chronic Disease; Chronic Illness; Clenbuterol; Country; Data; Drugs; E3 Ligase; E3 Ubiquitin Ligase; Ecological impact; Electroporation; Endocrine Gland Secretion; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fasting; Fluorescence; Funding; Gene Deletion; Gene Expression; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glucocorticoid Receptor; Glucocorticoids; Grant; Health; Hormones; Human; Human, General; Hyperglycemia; IACUC; IGF-1; IGF-I; IGF-I-SmC; IGF1; IRBs; Immobilization; Impact, Environmental; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; International; Intracellular Communication and Signaling; Investigators; Laboratories; Life; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Medication; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Murine; Mus; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Mutation; Nature; Nerve; Nervous; Paper; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; Regulatory Element; RegulatoryElement; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiratory physiology; Role; Senescence; Sepsis; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Somatomedin C; Study Section; Techniques; Therapeutic Glucocorticoid; Therapeutic Hormone; Transcription Activation; Transcriptional Activation; Transfection; Treatment Side Effects; Ubiquitin-Protein Ligase E3; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Work; abstracting; biological signal transduction; bloodstream infection; bone; chromatin immunoprecipitation; chronic disease/disorder; chronic disorder; clinical relevance; clinically relevant; drug/agent; experiment; experimental research; experimental study; expiration; expression vector; fasted; fasts; gene deletion mutation; gene induction; gene product; genetic resource; genome mutation; human subject; hyperglycemic; immobilization of body part; insulin resistant; interest; lung function; material transfer agreement; muscle form; orthopedic freezing; programs; research study; respiratory function; response; senescent; side effect; skeletal muscle wasting; social role; success; suprarenal gland; therapy adverse effect; tool; treatment adverse effect; ubiquitin-protein ligase; vertebrata",Glucocorticoid control of gene expression during skeletal muscle atrophy,,75801,SMEP,Skeletal Muscle and Exercise Physiology Study Section,,3,316770,
7762698,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK076647-04,,NIDDK:266635;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CHAMPAIGN,UNITED STATES,PHYSIOLOGY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"RAETZMAN, LORI T;",1952728;,5R01DK076647,02/01/2007,01/31/2012,"Activation, Gene; Address; Adenohypophysis; Affect; Alagille Syndrome; Alagille syndrome (AGS); Alagille-Watson Syndrome; Alagille-Watson syndrome (AWS); Alleles; Allelomorphs; Anaplastic; Animals; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Blood (Leukemia); Body Tissues; CADASIL; CRE Recombinase; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Chemotherapy-Hormones/Steroids; Cholestasis with Peripheral Pulmonary Stenosis; Clinical; Complement; Complement Proteins; Cre recombinase, Enterobacteria phage P1; Development; Disease; Disorder; Dorsal; Dysplasia, Arteriohepatic; Embryo; Embryonic; Endocrine; Endocrine Gland Secretion; Enterobacteria phage P1 Cre recombinase; Event; FLR; Failure (biologic function); Family member; Fecundability; Fecundity; Fertility; GHN; Gene Activation; Gene Expression; Gene Targeting; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth; Growth Hormone; Growth Hormone 1; Health; Hepatic Ductular Hypoplasia, Syndromatic; Hepatic ductular hypoplasia; Homeo Domain; Hormones; Human; Human, General; Hypophysis; Hypophysis Cerebri; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Lead; Leukemias, General; Ligands; METBL; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mother Cells; Murine; Mus; Mutant Strains Mice; Mutation; Nervous System, Pituitary; Notch Signaling Pathway; Nucleus; Null Mouse; Oncogenesis; Organ; Organ System, Cardiovascular; Organogenesis; Pars Anterior Pituitary Gland; Pathway interactions; Pattern; Pb element; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Growth Hormone; Pituitary Hormones; Pituitary Hypoplasia; Play; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Proteolysis and Signaling Pathway of Notch; RT-PCR; RTPCR; Receptor Protein; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; STH; Screening procedure; Sex Maturation; Sexual Maturation; Signal Transduction; Signal Transduction Systems; Signaling; Somatotropin; Spinal Column; Spine; Stem cells; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic Hormone; Tissue Growth; Tissues; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transgenic Organisms; Undifferentiated; Vascular, Heart; Vertebral column; Watson-Miller syndrome; arteriohepatic dysplasia; arteriohepatic dysplasia (AHD); backbone; bacteriophage P1 recombinase Cre; base; biological signal transduction; cardiovertebral syndrome; cell type; cholestasis-peripheral pulmonary stenosis; circulatory system; cofactor; disease/disorder; failure; gene product; genome mutation; hGHN; heavy metal Pb; heavy metal lead; hepatic ductular hypoplasia-multiple malformations syndrome; hepatofacioneurocardiovertebral syndrome; homeodomain; hormone deficiency; insight; leukemia; loris; loss of function; mRNA Expression; member; mouse mutant; mutant; notch; notch protein; notch receptors; notch-2 protein; notch2 protein; novel; null mutation; ontogeny; pathway; paucity of interlobular bile ducts; paucity of interlobular bile ducts (PILBD); pituitary gland development; precursor cell; prenatal; programs; receptor; receptor expression; reverse transcriptase PCR; screening; screenings; social role; somatotropic hormone; transcription factor; transgenic; tumorigenesis; unborn",Notch signaling regulates pituitary gland organogenesis,,76647,ICER,Integrative and Clinical Endocrinology and Reproduction Study Section,,4,266635,
7762827,R01,DK,5,,02/01/2010,01/31/2011,,5R01DK076770-04,,NIDDK:649600;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ASTOR, BRAD C;",2054104;,5R01DK076770,02/01/2007,01/31/2012,"21+ years old; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; Active Follow-up; Address; Admixture; Adult; Advanced Glycosylation End Products; Affect; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Albuminuria; Algorithms; Arts; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Black Populations; Black or African American; Blood Pressure, High; Blood Serum; CLG; CREA; Candidate Disease Gene; Candidate Gene; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Chronic Kidney Failure; Chronic Renal Disease; Clinical Practice Guideline; Clinical Practice Guidelines; Communities; Coronary Disease; Coronary heart disease; Creatinine; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Diabetes Mellitus; Differentiation Factor, B-Cell; Discipline; Disease Marker; Disease Outcome; Dysfunction; Elderly; Elderly, over 65; Epidemiology; Event; Fibroblast Collagenase; Framingham Heart Study; Functional disorder; GWAS; General Population; General Public; Genes; Genetic Markers; Genotype; Glomerular Filtration Rate; Glycation End Products, Advanced; Glycosylation End Products, Advanced; HPGF; Heart; Hepatocyte-Stimulating Factor; Human, Adult; Hybridoma Growth Factor; Hyperglycemia; Hypertension; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Incidence; Individual Differences; Inflammation; Institution; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Interstitial Collagenase; Investigators; Kidney; Kidney Diseases; Kidney Failure, Chronic; Lead; Linkage Disequilibrium; Linkage Disequilibriums; Longitudinal Studies; MGI-2; MMP-1; MMP-1Fibroblast Collagenase; MMP1; Maps; Matrix Metalloproteinase-1; Measurement; Measures; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Myeloid Differentiation-Inducing Protein; N(6)-carboxymethyllysine; N(epsilon)-(carboxymethyl)lysine; N(epsilon)-carboxymethyllysine; NECML; National Heart, Lung, and Blood Institute; Nephropathy; Organ System, Cardiovascular; Participant; Pathway interactions; Pb element; Physiopathology; Plasmacytoma Growth Factor; Play; Policies; Population; Procedures; Programs (PT); Programs [Publication Type]; Prospective Studies; Public Health; Race; Racial Group; Renal Disease; Renal Failure, Chronic; Renal function; Research Personnel; Research Resources; Researchers; Resources; Risk; Risk Factors; Role; Sampling; Scanning; Serologic; Serological; Serum; Stocks, Racial; Stratification; Testing; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; adult human (21+); advanced age; advanced glycation endproduct; atheromatosis; atherosclerotic vascular disease; base; black American; carboxymethyllysine; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; chronic kidney disease; circulatory system; clinical data repository; clinical data warehouse; cohort; coronary disorder; cystatin C; data repository; design; designing; diabetes; disease risk; disorder risk; elders; follow-up; genetic risk factor; genetic variant; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; geriatric; glomerular sclerosis; glomerulosclerosis; glycation; heavy metal Pb; heavy metal lead; hyperglycemic; hyperpiesia; hyperpiesis; hypertensive disease; inflammatory marker; inherited factor; interferon beta 2; kidney disorder; kidney function; late life; later life; long-term study; muscle form; nonenzymatic glycosylation; novel; novel marker; older adult; older person; pathophysiology; pathway; population based; post gamma-globulins; post-gamma-protein; programs; public health medicine (field); relational database; renal; renal disorder; senior citizen; serological marker; sex; social role; vascular inflammation; whole genome association studies; whole genome association study",Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease,,76770,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",,4,649600,
7778831,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK077050-02,,NIDDK:343574;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"STUENKEL, EDWARD L;",1884912;,5R01DK077050,03/01/2009,01/31/2013,"Affect; B9 endocrine pancreas; Binding; Binding (Molecular Function); Biochemical; Body Tissues; Capacitance, Electrical; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Competence; Complex; Coupled; Coupling; Cytoplasmic Granules; D-Glucose; Data; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Docking; Dysfunction; Electric Capacitance; Endocrine Gland Secretion; Event; Exocytosis; FRET; Family; Fluorescence Resonance Energy Transfer; Functional disorder; GTP; GTP Binding; GTP Phosphohydrolases; GTPases; Gastrointestinal Tract, Pancreas; Glucose; Goals; Growth and Development; Growth and Development function; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hormones; Humulin R; Hydrolysis; Inbred C3H Mice; Individual; Infection; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intracellular Communication and Signaling; Islands of Langerhans; Islet Cells; Islets of Langerhans; Kinetic; Kinetics; Life; Link; Location; MODY; Maintenance; Maintenances; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Membrane; Membrane Fusion; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Mice, Inbred C3H; Molecular; Molecular Interaction; Monitor; Mouse, C3H; Murine; Mus; NIDDM; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nucleotides; Optics; Organelles; Pancreas; Pancreas, Endocrine; Pancreatic; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Physiopathology; Population; Property; Property, LOINC Axis 2; Proteins; Rab27a protein; Regulation; Reporting; Research; Resistance; Role; SUBGP; Secretory Granules; Secretory Vesicles; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Staging; Stimulus; Subcellular Process; Subgroup; T2D; T2DM; Techniques; Therapeutic; Therapeutic Hormone; Therapeutic Intervention; Time; Tissues; Type 2 diabetes; Type II diabetes; Work; adult onset diabetes; beta cell development; biological signal transduction; blood glucose regulation; capacitance; diabetes; diabetic patient; disease/disorder; endocrine pancreas; endocrine pancreas development; experiment; experimental research; experimental study; fat metabolism; gene product; glucose control; glucose homeostasis; glucose regulation; granule; guanosinetriphosphatase; insulin secretion; intervention therapy; islet development; islet progenitor; ketosis resistant diabetes; lipid metabolism; maturity onset diabetes; membrane structure; mouse model; patch clamp; pathophysiology; pathway; public health relevance; rab 27a protein; research study; resistant; response; social role",Mechanisms of Rab27 regulation of insulin secretion," Narrative Insulin secreted by ¨-cells of pancreatic islets is essential for maintenance of glucose homeostasis as well as for tissue development and growth. Type-2 diabetes, a disease predicted to affect 250 million people worldwide by the year 2020, occurs when the ability of the ¨-cells to release insulin is exceeded by the requirements for the hormone to regulate glucose and lipid metabolism. In diabetic patients, early manifestations of ¨-cell dysfunction include delayed and blunted insulin secretory responses to glucose challenges and loss of tight stimulus-secretion coupling. Therefore, there is a critical necessity to understand in full molecular and mechanistic detail the secretory pathway underlying insulin secretion to ultimately develop therapeutic treatments for diabetes.",77050,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,2,343574,
7760049,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK077152-03,,NIDDK:329899;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,UNIVERSITY PARK,UNITED STATES,VETERINARY SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"PRABHU, KUMBLE SANDEEP ;",8214991;,5R01DK077152,02/01/2008,01/31/2012,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; 11-Dehydroprostaglandin F2 alpha; 11-Dehydroprostaglandin F2alpha; 2-cyclopenten-1-one; 9-deoxy-delta-9-PGD2; 9-deoxy-delta-9-prostaglandin D2; AIDS; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Active Follow-up; Active Oxygen; Aerobic; Affect; Alveolar; Alveolar Macrophages; Animal Welfare; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Applications Grants; Arachidonic Acid Cyclooxygenase; Arachidonic Acids; Arthritis; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Bibliography; Bioassay; Biochemical Reaction; Biologic Assays; Biological Assay; Body Tissues; Bone Marrow; Bp50; C57BL/6 Mouse; CD40; CDW40; COX; COX-1; COX-1 protein; COX-2 protein; COX1; COX2; COX2 enzyme; COX3; Cancer of Breast; Cancers; Candidate Disease Gene; Candidate Gene; Cardiovascular Diseases; Cell Line; Cell Lines, Strains; CellLine; Cells; Characteristics; Cigarette Smoker; Country; Covalent Interaction; Cyclo-Oxygenase; Cyclo-Oxygenase-1; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 3; Cytokines, Chemotactic; Data; Dehydration; Development; Diet; Dietary Intervention; Dinoprostone; Disease; Disorder; Douching, other than vaginal; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2; EC 2.5.1.18; EC 2.7; Ecological impact; Effector Cell; Endotoxins; Environment; Environmental Impact; Enzymatic Reaction; Enzymes; Equipment; Ethics Committees, Research; Event; Exhibits; Family; Fatty Acid Cyclo-Oxygenase; Fatty Acid Cyclooxygenase; Figs; Figs - dietary; GST; Gene Expression; Genes; Genetic; Glutathione; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione Transferase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Grant Proposals; Grants, Applications; Head; Heating; Hematopoietic; Heme Transfer Protein; Homologous Chemotactic Cytokines; Hydroperoxide Cyclase; IACUC; INFLM; IRBs; Immune Function, Cellular; Immune response; Immunity; Immunologic Deficiency Syndrome, Acquired; Impact, Environmental; In Vitro; Individual; Inflammation; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; Intermediary Metabolism; International; Intracellular Membranes; Irrigation; Irrigation, other than vaginal; Isoenzymes; Isozymes; Killings; Kinases; Knockout Mice; LPS; Lavage; Letters; Ligandins; Link; Lipopolysaccharides; Lung; METBL; MGC9013; Macrophage Activation; Macrophages, Alveolar; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Measurement; Measures; Mediating; Membrane; Metabolic; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Murine; Mus; Nature; Nonvaginal irrigation; Nonvaginal lavage; Nuclear; Null Mouse; Nutrition Interventions; Nutrition, Selenium; Nutritional; Nutritional Interventions; O element; O2 element; Outcome; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen Radicals; PERNUM; PGD synthase; PGD synthetase; PGD2; PGD2 isomerase; PGD2 synthase; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase; PGH Synthase 1; PGH Synthase 2; PGH2 Synthetase; PGHS-1; PGHS-2; PGHS2; PGJ2; PGR2 D-isomerase; PHS II; PHS1; PPAR; PTGS1; PTGS2; Pathology; Pathway interactions; Peritoneum; Peroxisome Proliferator-Activated Receptors; Personal Satisfaction; Phosphotransferases; Play; Principal Investigator; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9alpha,13E,15S)-; Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)-; Prostacyclins; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin D2; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin G/H Synthase 1; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H Synthase; Prostaglandin H2 Synthase; Prostaglandin H2 Synthase 1; Prostaglandin H2 Synthase 2; Prostaglandin H2 Synthetase; Prostaglandin Production; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostaglandins I; Prostanoids; Proteins; Pulmonary Macrophages; RNA, Small Interfering; RX[{..}]glutathione R-transferase; Reaction; Reactive Oxygen Species; Redox; Regulation; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Spleen; Role; S-Hydroxyalkyl Glutathione Lyase; SIS cytokines; Se element; Selenium; Selenium Trace Element Nutrition; Shunt; Shunt Device; Signal Pathway; Small Interfering RNA; Spleen; Stimulus; Supplementation; TNFRSF5; TNFRSF5 gene; Testing; Thromboxanes; Time; Tissues; Trace Element Nutrition, Selenium; Transferase; Transphosphorylases; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Vertebrate Animals; Vertebrates; abstracting; anti-oxidant; arthritic; atheromatosis; atherosclerotic vascular disease; base; beta-trace protein; body water dehydration; cardiovascular disorder; cell mediated immune response; cell type; chemoattractant cytokine; chemokine; cultured cell line; cyclo-oxygenase I; cyclo-oxygenase II; cyclooxygenase 1; cyclooxygenase 2; cyclopentenone; cytokine; design; designing; disease/disorder; experiment; experimental research; experimental study; expiration; follow-up; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; glutathione aralkyltransferase; glutathione aryltransferase; his-PG; host response; human subject; immune function; immunoresponse; information gathering; inhibitor; inhibitor/antagonist; insight; interest; irrigation therapy; knock-down; lavage therapy; lipid mediator; lipocalin-type PGD synthase; lipocalin-type PGDS; macrophage; malignancy; malignant breast neoplasm; member; membrane structure; mouse model; neoplasm/cancer; oxidant stress; oxidation reduction reaction; p50; pathway; progesterone 11-hemisuccinate-(2-iodohistamine); programs; prostaglandin D synthase; prostaglandin D2 synthase; prostaglandin D2-isomerase; prostaglandin H synthase-1; prostaglandin H synthase-2; prostaglandin H2 D-isomerase; prostaglandin J2; prostaglandin R2 D-isomerase; prostaglandin endoperoxide D-isomerase; pulmonary; reaction rate; research study; response; selenium deficiency; selenoenzyme; selenoprotein; shunts; siRNA; social role; success; thioether; transcription factor; vertebrata; well-being",Cellular Selenium Status and PGJ2 Metabolism,,77152,INMP,Integrative Nutrition and Metabolic Processes Study Section,,3,329899,
7764805,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK077777-03,,NIDDK:404077;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"APODACA, GERARD L;",1863505;,5R01DK077777,02/15/2008,11/30/2012,"ATP[{..}]adenosine 5'-phosphotransferase; Adenosine; Adenosine A1 Receptor; Adenosine Aminohydrolase; Adenosine Kinase; Affect; Agonist; Anabolism; Binding; Binding (Molecular Function); Biochemical; Biological Factors; Bladder; Bladder Diseases; Bladder Disorder; Body Tissues; Cardiovascular Physiology; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Complex; Data; Disease; Disorder; EC 3.5.4.4; Endocytosis; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Exocytosis; Factor, Biologic; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Goals; Grant; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HPLC; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; High Pressure Liquid Chromatography; Hydrostatic Pressure; Hyporeflexia; Internet; Interstitial Cystitis; Intracellular Communication and Signaling; Intracellular Second Messengers; Ions; Kidney; Knockout Mice; Lecithinase C; Mammals, Mice; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Protein Traffic; Membrane Traffic; Methods; Mice; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Murine; Mus; Natural Products; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleosides; Null Mouse; Organ System; Output; P1 Purinoceptors; Pathway interactions; Phospholipase C; Process; Production; Purinergic P1 Receptors; Receptor Protein; Receptors, Adenosine; Receptors, Purinergic P1; Recovery; Reflex, Decreased; Role; Second Messenger Systems; Second Messengers; Sensory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Surface; System; System, LOINC Axis 4; Testing; Tissues; Urinary System, Bladder; Urinary System, Kidney; WWW; Work; abstracting; adenosine deaminase; biological signal transduction; biosynthesis; body system; cardiovascular function; cultured cell line; disease/disorder; intravesical; lipophosphodiesterase I; membrane structure; neuronal; novel; pathway; phosphatidylcholine cholinephosphohydrolase; receptor; receptor expression; receptor function; renal; second messenger; social role; trafficking; urinary bladder; urinary bladder disorder; web; world wide web",Adenosine Receptor Function in Bladder Uroepithelium,,77777,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,3,404077,
7760917,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK077816-02,,NIDDK:275426;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LINCOLN,UNITED STATES,MISCELLANEOUS,01,555456995,US,NE,685880430,UNIVERSITY OF NEBRASKA LINCOLN,"ZEMPLENI, JANOS ;",6187589;,5R01DK077816,02/01/2009,01/31/2012,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 3-methylcrotonyl CoA carboxylase; Aberrant Chromosome; Abnormalities, Chromosomal; Acetyl Coenzyme A Carboxylase; Acetyl-CoA Carboxylase; Acetyl-CoA[{..}]carbon-dioxide ligase (ADP-forming); Address; Affect; Affinity; American; Amides; Assay; Autoregulation; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biotin; Biotinylation; CHIP assay; Cancers; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell surface; CellLine; Cells; Cellular Proliferation; ChIP (chromatin immunoprecipitation); Chaperone; Chromatin; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Co-Immunoprecipitations; Coenzymes; Cofactors, Enzyme; Computer Simulation; Computerized Models; Culture Media; Cytogenetic Aberrations; Cytogenetic Abnormalities; Cytoplasm; DNA Binding Domain; DNA Damage Repair; DNA Repair; DNA-Binding Proteins; Dietary intake; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Gene Action Regulation; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, Reporter; Genetic Transcription; Genome Stability; Genomics; Goals; Health; Heterochromatin; Histone H2A; Histone H3; Histone H4; Histones; Holocarboxylase Synthetase Deficiency; Homeostasis; Human; Human Cell Line; Human, General; K-18; K-18 conjugate; K12; K18; K18 combination; L-Lysine; Ligand Binding Protein; Ligase; Link; Lymphoid Cell; Lysine; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Models, Computer; Molecular Chaperones; Molecular Interaction; Multiple Carboxylase Deficiency, Neonatal Form; Multivitamin; Na element; Nuclear; Nuclear Translocation; Nucleus; Nutrient; Overdose; Physiological Homeostasis; Play; Pregnant Women; Process; Propionyl-CoA Carboxylase; Propionyl-Coenzyme A Carboxylase; Protein Motifs, DNA-Binding; Proteins; Public Health; Pyruvate Carboxylase; Pyruvate[{..}]carbon-dioxide ligase (ADP-forming); RNA Expression; RNA, Messenger; Recruitment Activity; Regulation; Relative; Relative (related person); Reporter Genes; Repression; Retrotransposon; Risk; Role; SECTM1; SECTM1 gene; Simulation, Computer based; Site; Sodium; Stability, Genomic; Structure; Supplementation; Synthetases; Techniques; Testing; Time; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Transgenic Organisms; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Unscheduled DNA Synthesis; Vitamin H; Vitamins; Yeasts; beta-methylcrotonyl-CoA carboxylase; biotin holocarboxylase synthetase; biotin symporter; biotin transporter; cancer risk; chromatin immunoprecipitation; chromatin remodeling; coenzyme R; coenzyme analog; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cultured cell line; experiment; experimental research; experimental study; gene product; gene repression; growth media; holocarboxylase synthetases; holoenzyme synthetase; in silico; mRNA; malignancy; meetings; methylcrotonoyl-CoA carboxylase; methylcrotonyl coA carboxylase; methylcrotonyl-coenzyme A carboxylase; methylmalonyl-CoA decarboxylase; neoplasm/cancer; public health medicine (field); public health relevance; pyruvic carboxylase; recruit; research study; response; sensor; social role; transgenic; uptake; virtual simulation",Biotin sensing and chromatin remodeling by holocarboxylase synthetase," Relevance to public health: Biotinylation of histones is a unique epigenetic mark because it depends on the dietary intake of the essential vitamin biotin. Biotin deficiency is prevalent among Americans, and moderate biotin deficiency has been observed in up to 50% of pregnant women. Previous studies suggest that biotinylation of histones plays a critical role in gene regulation and genomic stability, thereby decreasing the risk for chromosomal abnormalities and cancer.",77816,INMP,Integrative Nutrition and Metabolic Processes Study Section,,2,275426,
7763158,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK077967-03,,NIDDK:304833;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BUTLER, PETER CAWOOD;",1939957;,5R01DK077967,01/15/2008,01/31/2013,"Address; Aging; Animal Welfare; Autopsy; Beta Cell; Bibliography; Blood, Cord; Cellular biology; Childhood; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Color; Country; Diabetes Mellitus; Disease; Disorder; Donor, Organ; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fostering; Gastrointestinal Tract, Pancreas; Goals; Grafting, Pancreas; Human; Human, General; Humulin R; IACUC; IRBs; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Instruction; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; International; Life; Literature; Mammals, Rodents; Man (Taxonomy); Man, Modern; Modeling; Mother Cells; Natural immunosuppression; Natural regeneration; Novolin R; Obesity; Organ Donor; Pancreas; Pancreas Transplantation; Pancreatic; Pancreatic beta Cell; Paper; Patients; Preparation; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Publishing; Regeneration; Research; Research Ethics Committees; Research Resources; Resources; Rodent; Rodentia; Rodentias; Sampling; Senescence; Slide; Source; Stem cells; Structure of beta Cell of islet; Suggestion; Umbilical Cord Blood; Vertebrate Animals; Vertebrates; abstracting; adiposity; blind; cell biology; clinical investigation; corpulence; corpulency; corpulentia; diabetes; disease/disorder; expiration; fetal cord blood; human subject; immunosuppression; insulin secretion; medical examination; necropsy; non-diabetic; nondiabetic; obese; obese people; obese person; obese population; pancreas beta cell; pediatric; postmortem; programs; regenerate; response; senescent; vertebrata",Capacity and Mechanisms of Beta Cell Regeneration in Humans,,77967,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,3,304833,
7778297,R01,DK,5,,03/01/2010,02/28/2011,PAR-07-024,5R01DK078045-03,,NIDDK:589644;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"KEREN, RON ;",7042428;,5R01DK078045,04/14/2008,02/28/2013,"0-11 years old; 3 year old; 6 year old; Affect; Age; Age-Years; Ancillary Study; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bacterial Infections; Birth; Bladder; Blood; Child; Child Youth; Childhood; Children (0-21); Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Demographic Factors; Development; Diagnosis; Dialysis; Dialysis procedure; ESRD; Early treatment; Effectiveness; End stage renal failure; End-Stage Kidney Disease; Enrollment; Evaluation; Fever; Funding; Future; Genetic Determinism; Goals; Human, Child; Hyperthermia; INFLM; Incidence; Infection; Inflammation; Intervention; Intervention Strategies; Kidney; Kidney Diseases; Kidney Failure; Kidney Insufficiency; Miscellaneous Antibiotic; NIDDK; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; Nephropathy; Observational Study; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PBO; Parturition; Patients; Placebos; Prevention; Prevention Measures; Property; Property, LOINC Axis 2; Prophylactic treatment; Prophylaxis; Protocol; Protocols documentation; Pyrexia; Randomized; Randomized Controlled Trials; Recruitment Activity; Recurrence; Recurrent; Reflux; Renal Disease; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Reticuloendothelial System, Blood; Risk; Risk Factors; Screening procedure; Sham Treatment; Specificity; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Testing; Therapeutic Intervention; Time; UTI; Uncertainty; Ureter; Urinary System, Bladder; Urinary System, Kidney; Urinary System, Urine; Urinary tract infection; Urinary tract infectious disease; Urination; Urine; Vesico-Ureteral Reflux; Vesicoureteral Reflux; abstracting; acute pyelonephritis; anti-microbial; antimicrobial; bacterial disease; boys; children; clinical investigation; cohort; compare effectiveness; dialysis therapy; doubt; enroll; experience; falls; febrile; febris; genetic determinant; girls; high risk; indexing; intervention therapy; interventional strategy; kidney disorder; micturition; pediatric; prevent; preventing; prophylactic; randomisation; randomization; randomized controlled study; randomized placebo controlled study; randomized placebo controlled trial; randomly assigned; recruit; renal; renal disorder; renal scarring; screening; screenings; sham therapy; six year old; standard of care; surgery; three year old; transplant registry; uRNA; urinary; urinary bladder; voiding; youngster",Risk factors for renal scarring in children after urinary tract infection,,78045,ZDK1,Special Emphasis Panel,,3,589644,
7764650,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078076-03,,NIDDK:291060;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,KANSAS CITY,UNITED STATES,BIOCHEMISTRY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"FENTON, ARON W;",8024033;,5R01DK078076,02/19/2008,01/31/2013,"2-Propenoic acid, 2-(phosphonooxy)-, ion(1-); 3-D structure; 3-dimensional structure; 3D structure; Active Sites; Affinity; Allosteric Regulation; Amino Acids; Attenuated; Binding; Binding (Molecular Function); Binding Sites; Biological; Blood Serum; Carbohydrates; Catabolism; Cell Communication and Signaling; Cell Signaling; Chemicals; Chronic; Combining Site; Coupling; Crystallization; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; D-Glucose; Data; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dimethylbiguanidine; Dimethylguanylguanidine; Disease; Disorder; Drug Compounding; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Preparation; Drug Targeting; Drug Targetings; Drugs; Energy-Generating Resources; Enzyme Activation; Enzymes; Event; Fluorescence Anisotropy; Future; Genetic Alteration; Genetic Change; Genetic defect; Glucose; Glucose Plasma Concentration; Glycolysis; Goals; High Throughput Assay; Hormonal; Housing; Human; Human, General; Hyperglycemia; Hypoglycemic Agents; Hypoglycemic Drugs; Hypoglycemics; Imidodicarbonimidic diamide, N,N-dimethyl-; Individual; Intracellular Communication and Signaling; Isoenzymes; Isozymes; Knowledge; L-Type Pyruvate Kinase; Laboratories; Lead; Libraries; Ligand Binding; Ligands; Lilium; Lily; Linkage Analysis; Liver; Location; MODY; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Maturity-Onset Diabetes Mellitus; Medical Directors; Medication; Metformin; Molecular; Molecular Interaction; Monitor; Motion; Muscle; Muscle Tissue; Mutate; Mutation; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oryctolagus cuniculus; Outcome; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphoenolpyruvate; Phosphorylation; Phosphorylation Inhibition; Phosphorylation Site; Photometry/Spectrum Analysis, Mass; Physician Executives; Physiologic; Physiological; Plant Roots; Play; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Region; Proteins; Pyruvate Kinase; Pyruvate Kinase L; Rabbit, Domestic; Rabbits; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Regulation; Reporting; Resolution; Roentgen Rays; Role; Screening procedure; Serum; Side; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Site; Sites, Active; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; T2D; T2DM; Testing; Therapeutic; Type 2 diabetes; Type II diabetes; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; adiposity; adult onset diabetes; aminoacid; analog; antihyperglycemic; base; biological signal transduction; body system, hepatic; corpulence; corpulency; corpulentia; cross-link; crosslink; design; designing; diabetes; disease/disorder; drug development; drug/agent; energy source; family based linkage study; gene product; genetic linkage analyses; genetic linkage analysis; genome mutation; glucose metabolism; heavy metal Pb; heavy metal lead; high throughput screening; hyperglycemic; inhibitor; inhibitor/antagonist; insight; interest; ketosis resistant diabetes; linkage analyses; maturity onset diabetes; novel; obese; obese people; obese person; obese population; organ system, hepatic; pathway; phosphoenol transphosphorylase; phosphoenolpyruvate kinase; prevent; preventing; protein structure; response; root; screening; screenings; small molecule libraries; social role; three dimensional structure",Dissecting Allostery in Pyruvate Kinase,,78076,MSFE,Macromolecular Structure and Function E Study Section,,3,291060,
7763958,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078081-03,,NIDDK:340551;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"DANIAL, NIKA N.;",1904966;,5R01DK078081,02/01/2008,01/31/2013,"ATP[{..}]D-glucose 6-phosphotransferase; Active Follow-up; Address; Amino Acids; Animal Welfare; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; BH3 Domain; BH3 peptide; Bax protein (53-86); Beta Cell; Bibliography; Bioassay; Biologic Assays; Biological Assay; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell Respiration; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Respiration; Chemicals; Chemistry; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; Coupling; D-Glucose; Data; Defect; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Dysfunction; EC 2.7; Ecological impact; Editorial Comment; Editorial Comment (PT); Employee Strikes; Environment; Environmental Impact; Equilibrium; Equipment; Ethics Committees, Research; Event; Exhibits; Family; Family member; Fats; Fatty acid glycerol esters; Functional disorder; Future; Generations; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic defect; Genetics-Mutagenesis; Glucokinase; Glucose; Hand; Humulin R; IACUC; IRBs; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Intermediary Metabolism; International; Investigators; Kinases; Knock-out; Knockout; Knockout Mice; L-Serine; Lead; Leptin; Literature; METBL; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Modality; Modeling; Models, Genetic; Modification; Molecular; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Mutation; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Pb element; Peptides; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Physiology; Physiopathology; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Predisposition; Principal Investigator; Probability; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Conformation; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Published Comment; Recommendation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiration; Role; Science of Chemistry; Serine; Specific qualifier value; Specified; Strikes; Strikes, Employee; Structure; Subcellular Process; Suggestion; Susceptibility; T2D; T2DM; Testing; Therapeutic; Transphosphorylases; Type 2 diabetes; Type II diabetes; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; adult onset diabetes; aerobic metabolism; aerobic respiration; aminoacid; balance; balance function; base; diabetes; diabetic; expiration; follow-up; gain of function mutation; genome mutation; glucose metabolism; glucose tolerance; heavy metal Pb; heavy metal lead; human subject; improved functioning; innovate; innovation; innovative; insulin secretion; islet; ketosis resistant diabetes; knockin animal; maturity onset diabetes; member; mimetics; mitochondrial; mutant; necrocytosis; new therapeutic target; novel; ob/ob mouse; oxidative metabolism; pathophysiology; pro-apoptotic protein; programs; reconstitute; reconstitution; respiratory mechanism; social role; tool; vertebrata",The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival,,78081,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,3,340551,
7725825,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK078161-03,,NIDDK:316614;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PORTLAND,UNITED STATES,,01,071732663,US,ME,041023175,MAINE MEDICAL CENTER,"OXBURGH, LEIF ;",8666020;,5R01DK078161,02/01/2008,11/30/2012,"21+ years old; Adult; Allogenic; Anaplastic; Animal Welfare; Antirejection Therapy; BACs (Chromosomes); BMP7; BMP7 gene; Bacterial Artificial Chromosomes; Bibliography; Body Tissues; Bone Morphogenetic Protein 7 Gene; Cell Communication and Signaling; Cell Growth and Maintenance; Cell Maintenance; Cell Signaling; Cells; Chronic; Chronic Kidney Failure; Chronic Renal Disease; Clinical, Transplantation, Organ; Complementary DNA; Complex; Country; DNA, Complementary; Development; Dialysis; Dialysis procedure; ES cell; Ecological impact; Embryo; Embryonic; Engraftment; Environment; Environmental Impact; Equilibrium; Equipment; Ethics Committees, Research; GFAC; Goals; Grafting Procedure; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human, Adult; IACUC; IRBs; Immunosuppressive Therapy; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Kidney; Kidney Diseases; Kidney Failure, Chronic; Maintenance; Maintenances; Mice, Mutant Strains; Mother Cells; Mutant Strains Mice; Nephrons; Nephropathy; OP1 Gene; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Osteogenic Protein 1 Gene; Peripheral; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Renal Disease; Renal Failure, Chronic; Renal function; Research; Research Ethics Committees; Research Resources; Resources; Role; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Source; Stem cells; Study Section; System; System, LOINC Axis 4; Therapeutic immunosuppression; Therapy, Anti-Rejection; Tissues; Transgenes; Transgenic Organisms; Transplant Recipients; Transplantation; Transplantation Surgery; Undifferentiated; Urinary System, Kidney; Uriniferous Tube; Vertebrate Animals; Vertebrates; Work; abstracting; adult human (21+); artificial immunosuppression; balance; balance function; biological signal transduction; cDNA; cell type; chronic kidney disease; dialysis therapy; embryo tissue transplantation; embryonic stem cell; embryonic tissue transplantation; expiration; human subject; immunosuppression; in vivo; kidney development; kidney disorder; kidney function; mouse mutant; nephrogenesis; organ allograft; organ graft; organ xenograft; progenitor; programs; recombinase; regenerative therapy; renal; renal disorder; social role; stem cell of embryonic origin; transcription factor; transgenic; transplant; transplant patient; vertebrata",Defining the progenitor cell niche of the developing kidney,,78161,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,3,316614,
7743575,R01,DK,5,,12/01/2009,11/30/2010,PA-07-301,5R01DK078184-03,,NIDDK:310860;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DALLAS,UNITED STATES,MISCELLANEOUS,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"BURGESS, SHAWN C;",7615586;,5R01DK078184,02/01/2008,11/30/2012,"Animal Welfare; Autoregulation; Award; Bibliography; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Body Tissues; Carbohydrates; Citric Acid Cycle; Coagulation Factor I; Coagulation Factor One; Country; D-Glucose; Dextrose; Ecological impact; Environment; Environmental Impact; Enzymes; Equilibrium; Equipment; Ethics Committees, Research; Factor I; Factor One; Faculty; Fats; Fatty Acids; Fatty acid glycerol esters; Fibrinogen; Funding; Future; Genes; Gluconeogenesis; Glucose; Hepatic; Hepatic Mass; Homeostasis; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kidney; Krebs Cycle; Link; Lipids; Liver; Liver Mass; Mammals, Mice; Mammals, Rodents; Measurement; Measures; Metabolic; Metabolic Control; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Murine; Mus; Nuclear Magnetic Resonance; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); PEPCK; Pathway interactions; Phosphoenolpyruvate Carboxylase; Physiological Homeostasis; Preparation; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Pyruvate Carboxylase; Pyruvate[{..}]carbon-dioxide ligase (ADP-forming); RNA, Small Interfering; Research; Research Ethics Committees; Research Resources; Resources; Rodent; Rodentia; Rodentias; Small Interfering RNA; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TCA cycle; Techniques; Thesaurismosis; Time; Tissues; Tricarboxylic Acid Cycle; Urinary System, Kidney; Vertebrate Animals; Vertebrates; Work; abstracting; balance; balance function; body system, hepatic; expiration; fat metabolism; glucose RA; glucose biosynthesis; glucose production; glucose rate of appearance; human subject; interdisciplinary approach; interest; lipid metabolism; metabolism disorder; mouse model; organ system, hepatic; oxidation; pathway; phosphoenolpyruvate carboxykinase; programs; pyruvic carboxylase; renal; response; siRNA; surgery; vertebrata",Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer Analysis,,78184,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,3,310860,
7743098,R01,DK,5,,12/01/2009,11/30/2010,PA-07-068,5R01DK078187-03,,NIDDK:300960;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,NUTRITION,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"FINCK, BRIAN N;",6179134;,5R01DK078187,01/01/2008,11/30/2012,"ATP biosynthesis (oxidative); Animal Model; Animal Models and Related Studies; Animal Welfare; Atmosphere; Atmosphere, planetary; Automobile Driving; Autoregulation; Bibliography; Catabolism; Cells; Clinical; Complex; Core Facility; Country; Critiques; DNA Alteration; DNA mutation; DNA-Protein Interaction; Data; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Drivings, Automobile; Dysfunction; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Family; Fasting; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Liver; Functional disorder; Gene Alteration; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Mutation; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic mutation; Gluconeogenesis; Goals; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Hexadecanoates; Homeostasis; Hyperlipemia; Hyperlipidemia; IACUC; INFLM; IRBs; Impact, Environmental; Incidence; Inflammation; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Intermediary Metabolism; International; Investigators; Laboratories; Lead; Link; Lipids; Lipodystrophy; Lipoproteins; Liver; Liver Cells; Liver Steatosis; Liver diseases; METBL; MODY; Mammals, Mice; Mars; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Pathway; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Mitochondria; Molecular; Molecular Biology, Recombinant DNA; Molecular Genetic; Molecular Genetics; Murine; Mus; Mutation; NAFLD; NASH; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-alcoholic steatohepatitis; Nuclear Receptors; Obesity; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; PPAR; Palmitates; Pathogenesis; Pathway interactions; Pb element; Perinatal; Peroxisome Proliferator-Activated Receptors; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Planet Mars; Play; Prevalence; Principal Investigator; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Proteins; Publications; Publishing; RNA Expression; Reading; Recombinant DNA; Regulation; Regulatory Pathway; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Scientific Publication; Sequence Alteration; Suggestion; System; System, LOINC Axis 4; T2D; T2DM; Techniques; Thesaurismosis; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transfection; Triacylglycerol; Triglycerides; Type 2 diabetes; Type II diabetes; Universities; Vertebrate Animals; Vertebrates; Washington; Writing; abstracting; adiposity; adult onset diabetes; base; body system, hepatic; corpulence; corpulency; corpulentia; design; designing; disease/disorder; driving; experience; expiration; fasted; fasts; fat metabolism; fatty acid metabolism; fatty acid oxidation; gain of function; gene product; genome mutation; glucose biosynthesis; heavy metal Pb; heavy metal lead; hepatic steatosis; hepatopathy; human subject; insulin resistant; ketosis resistant diabetes; lipid metabolism; lipin; lipine; liver disorder; loss of function; maturity onset diabetes; metabolism disorder; mitochondrial; model organism; mouse model; mutant; neglect; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; organ system, hepatic; oxidation; pathophysiology; pathway; planetary Atmosphere; professor; programs; protein protein interaction; rDNA; response; social role; success; tool; transcription factor; vertebrata",LIPIN 1 IN THE REGULATION OF HEPATIC LIPID METABOLISM,,78187,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,3,300960,
7753232,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078192-03,,NIDDK:581127;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"GOODPASTER, BRET H.;",2050012;,5R01DK078192,03/01/2008,01/31/2013,"Abdomen; Abdominal; Address; Adipose tissue; Bariatrics; Body Composition; Body Weight decreased; Caloric Restriction; Cardiovascular Diseases; Ceramide (lipids); Ceramides; Characteristics; Data; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dysfunction; Exercise; Exercise, Physical; Fats; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Tissue; Fatty acid glycerol esters; Functional disorder; Health; Humulin R; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intervention Trial; Life Style; Lifestyle; Link; Lipids; MODY; Maturity-Onset Diabetes Mellitus; Measures; Metabolic; Metabolic syndrome; Mitochondria; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Patients; Physical activity; Physiopathology; Populations at Risk; Prevention; Randomized; Regulation; Research; Risk; Risk Factors; Role; Skeletal Muscle Tissue; Skeletal muscle structure; Stimulus; Surgical; Surgical Interventions; Surgical Procedure; T2D; T2DM; Triacylglycerol; Triglycerides; Type 2 diabetes; Type II diabetes; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; abdominal adiposity; abdominal fat; abstracting; adipose; adiposity; adult onset diabetes; bariatric surgery; body weight loss; calorie restriction; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; corpulence; corpulency; corpulentia; effective therapy; experience; fatty acid metabolism; fatty acid oxidation; gastric banding; gastric bypass surgery; implantable gastric stimulation banding; improved; insulin resistant; insulin sensitivity; ketosis resistant diabetes; maturity onset diabetes; mitochondrial; moderate obesity; novel; obese; obese people; obese person; obese population; obesity surgery; oxidation; pathophysiology; prevent; preventing; randomisation; randomization; randomly assigned; sedentary; social role; stomach stapling; surgery; weight control; weight loss surgery; white adipose tissue; wt-loss; yellow adipose tissue",Physical Activity Following Surgery-Induced Weight Loss,,78192,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,,3,581127,
7759186,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078618-03,,NIDDK:323978;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,ANESTHESIOLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"YOON, YISANG ;",1903509;,5R01DK078618,04/01/2008,01/31/2012,"Active Oxygen; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Biochemical; Biological; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; D-Glucose; Dextrose; Diabetes Mellitus; Disease; Disorder; EC 2.7; Electron Transport; Event; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Generations; Glucose; Health; Hour; Hyperglycemia; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Kinases; Mediating; Membrane; Methods; Mitochondria; Molecular; Morphology; Obesity; Organ; Organism; Oxygen Radicals; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphotransferases; Pro-Oxidants; Process; Production; PtdIns; R21 Award; Reactive Oxygen Species; Recovery; Regulation; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Structure; Subcellular Process; Testing; Transgenic Animals; Transphosphorylases; abstracting; adiposity; biological signal transduction; cell damage; cell injury; corpulence; corpulency; corpulentia; diabetes; disease/disorder; electron tomography; electron transfer; hyperglycemic; living system; membrane structure; mitochondrial; mitochondrial membrane; model organism; necrocytosis; obese; obese people; obese person; obese population; oxidative damage; prevent; preventing; social role; therapeutic target",Mitochondrial Dynamics in Hyperglycemic ROS Production,,78618,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,3,323978,
7762180,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078900-02,,NIDDK:363182;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"DANESH, FARHAD R.;",7756341;,5R01DK078900,02/01/2009,01/31/2014,"1-(5-isoquinolinesulfonyl)homopiperazine; 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-; Active Oxygen; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Agonist; Apoplexy; Arts; Behavior; Biochemical; Biological; Biosensor; Blood Pressure, High; Body Tissues; Cell Communication and Signaling; Cell Cycle Progression; Cell Function; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Proliferation; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Coenzyme II; Coronary Artery Vasospasm; Coronary Vasospasm; D-Glucose; Data; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetic Angiopathies; Diabetic Kidney Disease; Diabetic Nephropathy; Diabetic Vascular Complications; Diabetic Vascular Diseases; Diabetic Vascular Disorder; Dysfunction; Environment; Enzymes; Erectile dysfunction; Experimental Animal Model; Experimental Models; Experimental Models, Other; Fibrosis; Functional disorder; Gene Expression; Gene Targeting; Gene Transcription; Generations; Genetic Transcription; Glucose; H2O2; Heart failure; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hyperglycemia; Hypertension; In Vitro; Injury; Intracellular Communication and Signaling; Kidney; Kidney Failure; Kidney Insufficiency; Knock-in; Knock-in Mouse; Knockout Mice; Laboratories; Lead; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mitochondria; Modeling; Models, Experimental; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Motility; Motility, Cellular; Murine; Mus; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NADPH Oxidase; NIDDM; Nicotinamide-Adenine Dinucleotide Phosphate; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Null Mouse; O element; O2 element; Outcome; Oxidants; Oxidases; Oxidation-Reduction; Oxidizing Agents; Oxygen; Oxygen Radicals; P160ROCK; Pathogenesis; Pathway interactions; Pb element; Permeability; Phenotype; Physiopathology; Play; Pro-Oxidants; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; RNA Expression; ROCK1; ROCK1 gene; Reactive Oxygen Species; Redox; Renal Failure; Renal Insufficiency; Research; Rho-associated kinase; Rho-kinase; Role; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Source; Stroke; Structure; Subcellular Process; Superoxide Anion; Superoxide Radical; Superoxides; System; System, LOINC Axis 4; T2D; T2DM; Targetings, Gene; Technology; Testing; Therapeutic Uses; Threonine Kinase; Tissues; Transcription; Transcription, Genetic; Transgenic Mice; Transgenic Organisms; Triphosphopyridine Nucleotide; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; VESCL; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vesicle; adult onset diabetes; base; biological signal transduction; brain attack; cardiac failure; cell motility; cerebral vascular accident; diabetes; diabetic; electron acceptor; experiment; experimental research; experimental study; fasudil; gene product; glomerular sclerosis; glomerulosclerosis; heavy metal Pb; heavy metal lead; hyperglycemic; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; interstitial; ketosis resistant diabetes; maturity onset diabetes; microvascular complications; microvascular complications of diabetes; microvascular disease; migration; mitochondrial; new therapeutics; next generation therapeutics; novel; novel therapeutics; oxidation reduction reaction; pathophysiology; pathway; public health relevance; recombinase; renal; research study; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; sensor (biological); social role; stem; stroke; trafficking; transgene expression; transgenic; type I and type II diabetes",Role of Rho Kinases in Diabetic Nephropathy,  Diabetic nephropathy remains the leading cause of renal failure in the U.S. The current study will focus on a novel pathway possibly involved in the progression of diabetic kidney disease. We propose that inhibition of the RhoA/ROCK pathway holds promise as a novel therapeutic strategy to improve microvascular outcomes in diabetes.,78900,ZRG1,Special Emphasis Panel,,2,363182,
7753889,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK078965-02,,NIDDK:373032;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"KAO, HUNG-YING ;",7042547;,5R01DK078965,01/01/2009,12/31/2013,"Actin Filaments; Actin-Binding Protein; Actinin; Affect; Albumins; Assay; Behavior; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; CHIP assay; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Morphology; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Chemotherapy-Hormones/Steroids; Cultured Cells; Cytoplasm; DNA Alteration; DNA mutation; Data; Defect; Development; Disease; Disorder; Endocrine Gland Secretion; Epithelial Cells; Event; FSGS; Family; Family member; Filtration; Focal Segmental Glomerulosclerosis; Focal segmental glomerular sclerosis; Foot Process; Fractionation, Filtration; Future; Gene Alteration; Gene Expression; Gene Mutation; Gene Targeting; Gene Transcription; Genes; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic mutation; Glomerular disease; HDAC; HDAC Proteins; Histone Deacetylase; Hormones; Human; Human, General; Injury; Isoforms; Kidney Diseases; Kidney Glomerulus; Knock-in; Knock-in Mouse; Length; Ligands; Link; MEF-2; Malpighian Tuft; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Messenger RNA; Metabolic; Mice; Microfilaments; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Murine; Mus; Muscle; Muscle Tissue; Mutation; Myofilaments; NPHS1 gene product; NPHS2 protein; Nephropathy; Nephrotic Syndrome; Nuclear; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nuclear Receptors; Nucleus; PPAR; Pathogenesis; Pattern; Pedicel; Peroxisome Proliferator-Activated Receptors; Play; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Proteins; RNA Expression; RNA Splicing; RNA, Messenger; RNA, Small Interfering; Receptor Protein; Regulation; Regulator Genes; Renal Disease; Renal Glomerular Diseases and Syndromes; Renal function; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Reporter; Research; Role; Sequence Alteration; Small Interfering RNA; Splicing; Structural Protein; Structure; Subcellular Process; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic; Therapeutic Hormone; Toxin; Transcription; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Transcriptional Regulatory Elements; Transfection; Up-Regulation; Urinary System, Urine; Urine; Variant; Variation; Visceral Epithelial Cell; alpha Actinin; base; cell morphology; chromatin immunoprecipitation; cross-link; crosslink; disease/disorder; established cell line; gene product; genome mutation; glomerular sclerosis; glomerular visceral epithelial cell; glomerulosclerosis; histone modification; human disease; kidney disorder; kidney function; knock-down; mRNA; mef2 protein; mouse model; muscle-specific enhancer factor-2; mutant; myocyte enhancer factor 2; myocyte-specific enhancer-binding factor 2; nephrin; novel; podocin; podocyte; prevent; preventing; public health relevance; receptor; regulatory gene; renal disorder; renal glomerulus; response; siRNA; slit diaphragm; social role; trans acting element; transcription factor; wasting",Alpha actinin 4: its functions and regulation," Narrative One of the key functions of the kidney is to remove toxins and metabolic waste while preventing proteins larger than albumin from entering the urine. This process is mediated by highly specialized cells known as podocytes that produce critical components of the filtration barrier in glomeruli. Genetic mutations in a known cytoskeletal structural protein, ACTN4, have been linked to several glomerular diseases. We have identified a novel function of ACTN4 as a transcriptional coactivator in the nucleus that modulates the transcription of several hormone-sensitive genes. We will investigate the details of this nuclear function. We anticipate that our studies will uncover a previously underappreciated role for ACTN4 that is critical for podocyte functions and may have future therapeutic implications in kidney diseases.",78965,PBKD,Pathobiology of Kidney Disease Study Section,,2,373032,
7771733,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK078985-02,,NIDDK:293040;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MINNEAPOLIS,UNITED STATES,NUTRITION,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"KOTZ, CATHERINE M;",1882946;,5R01DK078985,02/20/2009,01/31/2013,"Affect; American; Animal Model; Animal Models and Related Studies; Animals; Area; Arousal; BMI percentile; BMI z-score; Body Weight; Body mass index; Brain; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Signaling; Common Rat Strains; Data; Development; Diabetes Mellitus; Disease; Disorder; Dose; Encephalon; Encephalons; Environment; FOS gene; Foundations; G0S7; Goals; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Health; Heart Diseases; Heat Production; Human; Human, General; Hypothalamic structure; Hypothalamus; Individual; Intracellular Communication and Signaling; Knowledge; Lead; Life; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuromodulator; Neurons; Obesity; Over weight; Overweight; Pb element; Peptides; Physical activity; Population; Protooncogene FOS; Quetelet index; Rat; Rats, Sprague-Dawley; Rattus; Receptor Protein; Regulation; Regulatory Pathway; Relative; Relative (related person); Research; Resistance; Risk Factors; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sprague-Dawley Rats; Study models; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Thermogenesis; Time; Variant; Variation; Weight Gain; Weight Increase; adiposity; base; biological signal transduction; body weight gain; body weight increase; brain pathway; c fos; c-fos Gene; c-fos Proto-Oncogenes; cancer type; corpulence; corpulency; corpulentia; diabetes; disease/disorder; energy balance; heart disorder; heavy metal Pb; heavy metal lead; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; intervention therapy; model organism; neural; neuronal; obese; obese people; obese person; obese population; obesigenic; obesity treatment; orexin; orexin A; public health relevance; receptor; receptor expression; relating to nervous system; resistant; social role; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; wt gain",Spontaneous physical activity in obesity," The current proposal is aimed at understanding the role of a specific brain pathway that controls physical activity, which is important to body weight regulation. Obesity is a major health problem affecting at least one third of the U.S. population, and is a risk factor for several diseases, including heart disease, diabetes and several types of cancer. Underlying part of the problem is disordered regulation of physical activity, and a better understanding of the brain pathways important to this is necessary in developing treatments for obesity.",78985,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,2,293040,
7760911,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK079974-03,,NIDDK:369765;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BRONX,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"GABRIELY, ILAN ;",6956861;,5R01DK079974,02/01/2008,01/31/2013,"ATP[{..}]D-glucose 6-phosphotransferase; Achievement; Achievement Attainment; Acute; Aeroseb-HC; Animal Welfare; Animals; Antidiabetic Hormone; Arousal; Arts; Attenuated; Autoregulation; Award; Beta Cell; Bibliography; Biochemical; Blood Plasma; Body Tissues; Boots Brand of Naloxone Hydrochloride; Brain; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; C-Fragment Endorphin; Catecholamines; Cetacort; Chemotherapy-Hormones/Steroids; Clinical Investigator; Clinical Research; Clinical Study; Complications of Diabetes Mellitus; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Country; D-Glucose; Data; Dermacort; Deterioration; Development; Dextrose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetes-Related Complications; Diabetic Complications; Disease; Disorder; Dose; Drip Infusions; Drip, Intravenous; Ecological impact; Effectiveness; Eldecort; Encephalon; Encephalons; Endo Brand of Naloxone Hydrochloride; Endocrine Gland Secretion; Endogenous Opiates; Endorphins; Environment; Environmental Impact; Enzymes; Equipment; Ethics Committees, Research; Exercise; Exercise, Physical; FLR; Failure (biologic function); Fasting; Fructose; GCG; GHN; Glucagon; Glucagon (1-29); Glucokinase; Gluconeogenesis; Glucose; Glucose Plasma Concentration; Glucose-6-Phosphate; Glukagon; Glycogen; Grant; Growth Hormone; Growth Hormone 1; HG-Factor; Hepatic; Hepatic Glycogen; Homeostasis; Hormonal; Hormones; Human; Human, General; Humulin R; Hydrocortisone; Hydrocortone; Hyperglycemic-Glycogenolytic Factor; Hypoglycemia; Hytone; IACUC; IDD; IDDM; IRBs; IV Infusion; Impact, Environmental; Individual; Infusion; Infusion procedures; Infusions, Intravenous; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; International; Intravenous infusion procedures; K23 Award; K23 Mechanism; K23 Program; Laboratories; Lamepro Brand of Naloxone Hydrochloride; Lead; Levulose; Lipotropin 61-91; Lipotropin Fragment C; Literature; Liver Glycogen; Man (Taxonomy); Man, Modern; Memory; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Mentorship; Metabolic; Method LOINC Axis 6; Methodology; Methodology, Research; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-; Naloxone; Names; Narcan; Narcanti; Nervous System, Brain; Neuroendocrine; Neuroendocrine System; Neurologic; Neurological; Neurosecretory Systems; Novolin R; Nutracort; Opioid Receptor; Pathway interactions; Patients; Pb element; Persons; Physiological Homeostasis; Pituitary Growth Hormone; Plasma; Play; Predisposition; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Principal Investigator; Proctocort; Programs (PT); Programs [Publication Type]; Receptors, Opiate; Recovery; Recurrence; Recurrent; Regulation; Research; Research Ethics Committees; Research Methodology; Research Methods; Research Resources; Research Training; Resources; Reticuloendothelial System, Serum, Plasma; Risk; Role; STH; Serum, Plasma; Somatotropin; Source; Stress; Susceptibility; Sympathins; Syndrome; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; Tag; Therapeutic Hormone; Therapeutic Hydrocortisone; Time; Tissues; Tracer; Type 1 diabetes; United Drug Brand of Naloxone Hydrochloride; Vertebrate Animals; Vertebrates; abstracting; beta-Endorphin; beta-LPH (61-91); beta-Lipotropin C Fragment; counterregulation; diabetes; diabetes control; disease/disorder; endogenous opioid; expiration; failure; fasted; fasts; glucose RA; glucose biosynthesis; glucose production; glucose rate of appearance; glucose uptake; glycemic control; glycogen metabolism; glycogenolysis; hGHN; heavy metal Pb; heavy metal lead; human subject; hypoglycemia unawareness; hypoglycemic; hypoglycemic episodes; improved; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; new approaches; new therapeutic target; non-diabetic; nondiabetic; novel approaches; novel strategies; novel strategy; pathway; prevent; preventing; programs; response; social role; somatotropic hormone; tool; type I diabetes; vertebrata",Mechanisms of Hypoglycemia Associated Autonomic Failure,,79974,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,,3,369765,
7760919,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK080010-02,,NIDDK:333754;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NASHVILLE,UNITED STATES,BIOCHEMISTRY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"WAGNER, CONRAD ;",1881309;,5R01DK080010,02/01/2009,01/31/2013,"0-11 years old; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-; 2-amino-4-mercaptobutyric acid; 3-Pyridinecarboxamide; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-; 5-Methyluracil; Ademetionine; Adenosine, 5'-((3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy-, inner salt, (3S)-; AdoMet; Affect; Age; Age-Months; Amines; Amino Acids; Aminoacetic Acid; Animal Feed; Animals; Appearance; Bet-HCys MTase; Betaine-homocysteine S-methyltransferase; Binding; Binding (Molecular Function); Blood Plasma; Blood Serum; Body Tissues; Butanoic acid, 4,4'-dithiobis(2-amino)-; C element; CREA; Cancers; Carbon; Carcinoma of the Liver Cells; Cell/Tissue, Immunohistochemistry; Cells; Child; Child Youth; Children (0-21); Cirrhosis; Code; Coding System; Coenzymes; Cofactors, Enzyme; Collection; Creatine; Creatinine; DNA; DNA Methylation; DNA Replication; DNA Synthesis; DNA biosynthesis; Data; Deoxyribonucleic Acid; Development; Diet; EC 2.1.1; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Exocrine pancreas; Family; Fatty Liver; Fibrosis; Folate; Folate Metabolism; Folic Acid Deficiency; Folic Acid Metabolosm; Formaldehyde; Formic Aldehyde; Gastrointestinal Tract, Pancreas; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Male, Prostate; Genomics; Glycine; Glycine, N-(aminoiminomethyl)-N-methyl-; Glycine, N-methyl-; Goals; HCC; Hepatic Cancer; Hepatic Disorder; Hepatic Tissue; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Histologic; Histologically; Histology; Histones; Homocysteine; Homocysteine, L-Isomer; Homocystine; Human; Human Prostate; Human Prostate Gland; Human, Child; Human, General; Hypermethylation; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Inflammation; Intermediary Metabolism; Intestinal Mucosa; Kidney; Knock-out; Knockout; Knockout Mice; L-Methionine; Link; Liver; Liver Steatosis; Liver diseases; METBL; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Metabolic Processes; Metabolism; Methanal; Methionine; Methionine Metabolism; Methionine Metabolism Pathway; Methionine, L-Isomer; Methods; Methyl Aldehyde; Methylation; Methylglycine; Methyltransferase; Mice; Mice, Knock-out; Mice, Knockout; Missense Mutation; Modeling; Molecular Interaction; Murine; Mus; Mutation; Mutation, Missense; N-Methylglycine; Niacinamide; Nicotinamide; Nicotinamidum; Nicotinic acid amide; Nicotylamide; Null Mouse; Oxomethane; Pancreas; Pancreatic; Pancreatic Secretion; Pathology; Pathway interactions; Pellagra-Preventing Factor; Plasma; Play; Primary carcinoma of the liver cells; Process; Production; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Prostate; Prostate Gland; Prostatic Gland; Protein Methylation; Proteins; Purines; Reaction; Regulation; Research; Reticuloendothelial System, Serum, Plasma; Role; S-Adenosylmethionine; SAMe; Sarcosine; Serum; Serum, Plasma; Severities; Steatohepatitis; Submandibular gland; Submaxillary Gland; Targetings, Gene; Testing; Tetrahydrofolates; Thymine; Time; Tissues; Urinary System, Kidney; Urinary System, Urine; Urine; Vitamin B 3; Vitamin B3; Vitamin PP; aminoacid; animal food; animal tissue; betaine-homocysteine methyltransferase; body system, hepatic; children; coenzyme analog; enzyme activity; feeding; folate carrier; folate deficiency; folate receptor; folate-binding protein; folate-methotrexate transporter; folic acid binding protein; folic acid metabolism; folic acid receptor; gene product; genetic promoter element; genome mutation; glycine N-methyltransferase; glycine methyltransferase; glycine sarcosine N-methyltransferase; glycine sarcosine methyltransferase; guanidinoacetate; hepatic steatosis; hepatopathy; in vivo; indexing; inhibitor; inhibitor/antagonist; liver cancer; liver disorder; malignancy; malignant liver tumor; methotrexate-binding protein; methyl group; methylase; mouse model; neoplasm/cancer; organ system, hepatic; oxidation; pancreatic juice; pathway; prevent; preventing; public health relevance; purine; renal; s-adenosyl-l-methionine; social role; transmethylase; youngster",Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism," Project Narrative  This proposal ""Folate and S-adenosylmethionine in Methyl Group and One-carbon Metabolism"" deals with the effects of the loss of the enzyme, glycine N-methyltransferase, a major enzyme in liver, pancreas and the prostate gland. We have discovered mutations of this enzyme in several children that result in moderate liver damage and have developed a mouse model that has a complete absence of glycine N-methyltransferase that progresses to severe liver disease as they get older. One of the goals of this proposal is to evaluate the use of several common natural compounds for their ability to diminish the development of liver damage in this mouse model thus raising the possibility of treating humans with defective glycine N-methyltransferase and prevent serious liver damage.",80010,INMP,Integrative Nutrition and Metabolic Processes Study Section,,2,333754,
7758180,R01,DK,5,,02/01/2010,01/31/2011,PA-07-058,5R01DK080048-02,,NIDDK:406082;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"JAMESON, JULIE M;",2048255;,5R01DK080048,02/01/2009,01/31/2014,"ATGN; Address; Affect; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Antigens; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Autoregulation; Body Tissues; CD25; Cell Communication; Cell Communication and Signaling; Cell Count; Cell Death, Programmed; Cell Function; Cell Interaction; Cell Number; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Charcot foot; Chronic; Co-Stimulator; Complex; Complication; Complications of Diabetes Mellitus; Costimulator; Data; Defect; Development; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes-Related Complications; Diabetic Complications; Diabetic Foot; Diabetic mouse; Dimethylbiguanidine; Dimethylguanylguanidine; Dysfunction; Environment; Epidermal Thymocyte Activating Factor; Epidermis; Epithelial; Epithelial Cells; Epithelium; Exhibits; Functional disorder; Funding; Funding Mechanisms; GFAC; Glucocorticoids; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Healed; Homeostasis; Humulin R; Hyperglycemia; IGF-1; IGF-I; IGF-I-SmC; IGF1; IL-2; IL2; IL2 Protein; IL2R; IL2RA; IL2RA gene; Imidodicarbonimidic diamide, N,N-dimethyl-; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immune system; Immunologic Diseases; Immunological Diseases; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intestinal; Intestines; Intracellular Communication and Signaling; Knowledge; Laboratories; Lead; Lung; Lymphocyte; Lymphocyte Mitogenic Factor; Lymphocytic; MHC Receptor; MODY; Major Histocompatibility Complex Receptor; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Mediating; Metformin; Mice; Mitogenic Factor; Modeling; Murine; Mus; NIDDM; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Pathway interactions; Patients; Pb element; Physiological Homeostasis; Physiopathology; Play; Population; Process; Production; Proliferating; Receptor Protein; Receptors, Antigen, T-Cell; Research; Respiratory System, Lung; Role; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Somatomedin C; Staging; Stress; Study models; Subcellular Process; T cell growth factor; T-Cell Activation; T-Cell Growth Factor; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T2D; T2DM; TCGFR; Testing; Therapeutic Glucocorticoid; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Tissues; Type 2 diabetes; Type II diabetes; ULCN; Ulcer; Ulceration; United States National Institutes of Health; Work; Wound Healing; Wound Repair; adult onset diabetes; anergy; anti-diabetic drugs; antidiabetic; base; biological signal transduction; body system, allergic/immunologic; bowel; cytokine therapy; diabetes; diabetic; experience; healing; heavy metal Pb; heavy metal lead; hyperglycemic; immunogen; improved; in vivo; insulin resistant; interest; keratinocyte; ketosis resistant diabetes; lymph cell; maturity onset diabetes; mouse model; mouse model of diabetes; new approaches; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathophysiology; pathway; public health relevance; pulmonary; receptor; receptor expression; repair; repaired; reproductive; response; social role; thymus derived lymphocyte; tissue repair",Altered gamma delta T cell-keratinocyte interplay in the skin of diabetic mice, Project Narrative T cells in the skin are stimulated by damaged keratinocytes to produce growth factors important for wound repair. Chronic non-healing wounds are a serious complication of diabetes with devastating consequences. The goal of our research is to determine how type 2 diabetes alters T cell survival and function in the epithelia and whether this process can be reversed therapeutically to promote healing of chronic wounds.,80048,SAT,"Surgery, Anesthesiology and Trauma Study Section",,2,406082,
7762764,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK080112-03,,NIDDK:237092;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"SARNAK, MARK J;",6411080;,5R01DK080112,02/01/2008,01/31/2012,"2-amino-4-mercaptobutyric acid; Active Follow-up; Affect; Age; Aged 65 and Over; Animal Welfare; Anisotropy; Assay; Atrophic; Atrophy; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blood Plasma; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; Blood Serum; Blood Vessels; Brain; Brain Vascular Disorders; Butanoic acid, 4,4'-dithiobis(2-amino)-; Ca++ element; Calcium; Carbamide; Cerebrovascular Circulation; Cerebrovascular Disease; Cerebrovascular Disorders; Clinic; Coagulation Factor IV; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Collaborations; Consent; Control Groups; Country; Data; Development; Diabetes Mellitus; Dialysis; Dialysis patients; Dialysis procedure; Diffusion; Disease; Disorder; Disturbance in cognition; Dysfunction; Dyslipidemias; ECSF; ESRD; Ecological impact; Education; Educational aspects; Elaqua XX; Elderly; Elderly, over 65; Encephalon; Encephalons; End stage renal failure; End-Stage Kidney Disease; Enrollment; Environment; Environmental Impact; Epoetin; Equipment; Erythropoietin; Ethics Committees, Research; Evaluation; Factor IV; Functional disorder; Gender; General Population; General Public; Goals; Grant; Hemodialyses; Hemodialysis; Hemoglobin; High Prevalence; Homocysteine; Homocysteine, L-Isomer; Homocystine; Hypertension; Hypotension; IACUC; INFLM; IRBs; Impact, Environmental; Impaired cognition; Incidence; Inflammation; Institutional Animal Care and Use Committee; Institutional Review Boards; Interdisciplinary Research; Interdisciplinary Study; Intermediary Metabolism; International; Intervention; Intervention Strategies; Intracranial Vascular Disorders; Kidney Diseases; Kidney Failure; Kidney Insufficiency; METBL; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malnutrition; Massachusetts; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic Processes; Metabolism; Multidisciplinary Collaboration; Multidisciplinary Research; NMR Imaging; NMR Tomography; Names; Nephropathy; Nervous System, Brain; Network Analysis; Neurocognitive; Nuclear Magnetic Resonance Imaging; Nutritional Deficiency; O element; O2 element; Out-patients; Outpatients; Oxidative Stress; Oxygen; P element; PTH (1-84); PTH protein, human; Parathyroid Hormone; Parathyroid Hormone (1-84); Parathyroid Hormones; Participant; Pathway Analysis; Pathway interactions; Patients; Phase; Phosphorus; Physiopathology; Plasma; Population; Prevalence; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Public Health; QOL; Quality of life; Renal Disease; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Serum, Plasma; Risk Factors; Serum; Serum Albumin; Serum, Plasma; Severities; Study, Interdisciplinary; Survivors; Testing; Time; Undernutrition; Urea; Urea Carbamide; Ureaphil; VIT D; Vascular Diseases; Vascular Diseases, Intracranial; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vertebrate Animals; Vertebrates; Vitamin D; Zeugmatography; abstracting; advanced age; aging population; analog; blood vessel disorder; calcium metabolism; cerebral blood flow; cerebral circulation; cerebrocirculation; cinacalcet; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cohort; diabetes; dialysis therapy; dietary deficiency; disease/disorder; elders; enroll; erythrocyte colony stimulating factor; expiration; follow-up; gene product; geriatric; hPTH(1-84); hematopoietin; hemodynamics; human PTH protein; human subject; hyperpiesia; hyperpiesis; hypertensive disease; inflammatory marker; instrument; interest; interventional strategy; kidney disorder; late life; later life; neuron cell death; neuron loss; neuron toxicity; neuronal cell death; neuronal loss; neuronal toxicity; neurotoxicity; older adult; older person; oxidant stress; parathormone; parathyroid hormone, human; pathophysiology; pathway; patient population; primary outcome; programs; public health medicine (field); renal disorder; senior citizen; substantia alba; vascular; vertebrata; white matter",Cognition and Dialysis,,80112,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",,3,237092,
7743369,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK080147-03,,NIDDK:317329;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LA JOLLA,UNITED STATES,PEDIATRICS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"JHALA, ULUPI S;",7631756;,5R01DK080147,02/05/2008,11/30/2012,"AKT; APF-1; ATP-Dependent Proteolysis Factor 1; Agonist; Akt protein; Animal Model; Animal Models and Related Studies; Animal Welfare; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Autoimmune; Autoimmune Process; BAX; BAX gene; BCL2-Associated X Protein Gene; BCL2L4; Beta Cell; Bibliography; Biological; Blood leukocyte; Causality; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Ceramide (lipids); Ceramides; Country; DIF; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Etiology; Event; Genetic; HMG-20; Hand; High Mobility Protein 20; Humulin R; IACUC; IDD; IDDM; IL-1; IL1; IRBs; Impact, Environmental; Inbred NOD Mice; Infiltration; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Insulin-Dependent Diabetes Mellitus; Interleukin I; Interleukin-1; International; Intracellular Communication and Signaling; JNK; JNK1; JNK1A2; JNK21B1/2; Kinases; Leukocytes; Link; Lymphocyte-Stimulating Hormone; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; MLK-3 protein; MODY; Macrophage Cell Factor; Maps; Marrow leukocyte; Maturity-Onset Diabetes Mellitus; Mediating; Mice, Inbred NOD; Mitochondria; Modeling; Mouse, NOD; NIDDM; Names; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-Obese Diabetic Mice; Nonobese Diabetic Mouse; Novolin R; PKB protein; PRKM8; Pancreatic beta Cell; Pathway interactions; Peptides; Phosphorylation; Phosphotransferases; Play; Polyubiquitination; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Predisposition; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Kinase B; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proto-Oncogene Proteins c-akt; RAC-PK protein; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Leukocytes; Role; SAPK1; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Stress; Structure of beta Cell of islet; Susceptibility; T Helper Factor; T1 diabetes; T1D; T1DM; T2D; T2DM; TNF; TNF A; TNF gene; TNFSF2; Time; Transphosphorylases; Tumor Necrosis Factor Gene; Type 1 diabetes; Type 2 diabetes; Type II diabetes; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Vertebrate Animals; Vertebrates; White Blood Cells; White Cell; abstracting; adult onset diabetes; attenuation; base; biological signal transduction; c-akt protein; cytokine; db/db mouse; diabetes; diabetic; disease causation; disease etiology; disease/disorder etiology; disorder etiology; expiration; human subject; insulin dependent diabetes; islet; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; ketosis resistant diabetes; lymphocyte activating factor; maturity onset diabetes; mitochondrial; mixed lineage kinase 3; model organism; necrocytosis; pancreas beta cell; pathway; programs; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; response; social role; type I and type II diabetes; type I diabetes; type I diabetic; ubiquination; ubiquitin conjugation; upstream kinase; vertebrata; white blood cell; white blood corpuscle",Signaling Cascades in Regulation of Pancreatic Beta cell mass.,,80147,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,3,317329,
7754649,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK080459-02,,NIDDK:537664;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"DAVIES, TERRY FRANCIS;SUN, LI ;ZAIDI, MONE  (contact);",1867741;2101578 (contact);6986068;,5R01DK080459,01/05/2009,11/30/2013,"3,5,3',5'-Tetraiodothyronine; 55 kDa Erythrocyte Membrane Protein; Abscission; Acute; Adenohypophyseal Hormones; Affect; Agonist; American; Anterior Pituitary Hormones; Antibodies; Arts; Attenuated; Basedow's Disease; Blood Serum; Bone; Bone Diseases; Bone Formation; Bone Resorption; Bone and Bones; Bone structure of spine; Bones and Bone Tissue; C-telopeptide; CD11b; CR3A; Cancer Cause; Cancer Etiology; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cessation of life; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Common Rat Strains; Coxa; Data; Death; EMP55; Erythrocyte Membrane Protein p55; Excision; Extirpation; Foundations; Fracture; Future; Genetic Alteration; Genetic Change; Genetic defect; Goals; Goiter, Exophthalmic; Graves' Disease; Hip; Hip region structure; Human; Human, General; Hyperthyroidism; ITGAM; ITGAM gene; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; In Vitro; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; Levothyroxine; MAC-1; MAC1A; MO1A; MPP1 protein, human; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mice; Moab, Clinical Treatment; Modeling; Molecular; Monoclonal Antibodies; Murine; Mus; Mutation; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Oophorectomy; Osteoblasts; Osteoclastic Bone Loss; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; PEMP; Palmitoylated Membrane Protein 1; Palmitoylated Membrane Protein 1 55kD; Patients; Phenotype; Pituitary Hormones; Pituitary Hormones, Anterior; Play; Population; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Prevention; Production; Rat; Rattus; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, Thyroid Stimulating Hormone; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Removal; Reporting; Risk; Role; Sensitization, Immunologic; Sensitization, Immunological; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Skeleton; Spinal Fractures; Stromal Cells; Surgical Removal; T4 Thyroid Hormone; TSH Receptors; TSH receptor antibody; Therapeutic; Therapeutic Levothyroxine; Thyreotropin; Thyroid Function Tests; Thyroid Gland Function Tests; Thyroid Gland Hormone; Thyroid Hormones; Thyroid Stimulating Hormone; Thyroid-Stimulating Hormone; Thyrotropin; Thyrotropin Receptor; Thyroxine; Time; Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-; Vertebrae; Vertebral; Woman; biological signal transduction; bone; bone cell; bone disorder; bone fracture; bone loss; cytokine; disability; female gonadectomy; genome mutation; human MPP1 protein; human data; implantation; in vivo; membrane protein, palmitoylated 1, 55kDa, human; mutant; osteoclastogenesis; overactive thyroid; p55; p75; p75 transcription factor; palmitoylated erythrocyte membrane protein p55, human; post-menopausal; postmenopausal; prevent; preventing; public health relevance; receptor; reconstitute; reconstitution; resection; restoration; skeletal; social role; spine bone structure; thyroid function; thyroxin; transcriptional coactivator p75; vertebral fracture",TSH and Bone," Hyperthyroidism affects one in 1000 American women and is accompanied by osteoporosis and a high fracture risk. We showed that decrements in the pituitary hormone TSH accompany the high thyroid hormone levels, both of which contribute to the bone loss. This proposal examines the molecular mechanism through which TSH acts directly on the skeleton.",80459,SBSR,Skeletal Biology Structure and Regeneration Study Section,,2,537664,
7759165,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK080805-04,,NIDDK:307098;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,HERSHEY,UNITED STATES,BIOCHEMISTRY,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"YOCHUM, GREGORY S.;",9076759;,5R01DK080805,04/10/2008,01/31/2013,"5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; AHH; AHRR; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; APC; APC - Adenomatous Polyposis Coli; APC gene; ATF; Activator Protein-1; Address; Adeno-Associated Viruses; Adenomatosis Polyposis Coli Gene; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Agar; Alleles; Allelomorphs; Antibodies; Assay; Athymic Nude Mouse; Autoregulation; BUdR; Binding; Binding (Molecular Function); Binding Site Domain; Binding Sites; Bioassay; Biologic Assays; Biological Assay; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CHIP assay; CP11; CY11; CYP1; CYP1A1; CYP1A1 gene; Cancer Induction; Cancers; Carcinoma Cell; Carcinoma of the Large Bowel; Carcinoma of the Large Intestine; Cell Communication and Signaling; Cell Cycle; Cell Differentiation; Cell Differentiation process; Cell Division Cycle; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cellular Migration; Cellular Proliferation; Cellular Transformation; ChIP (chromatin immunoprecipitation); Chromatin; Colorectal Cancer; Colorectal Carcinomas; Combining Site; Consensus; DP2; DP2.5; DP3; Defect; Dependovirus; Development; Differentiation and Growth; Elements; Engineering; Engineerings; Enhancer-Binding Protein AP1; Enhancers; Estrogen Receptors; FPC; Familial Adenomatous Polyposis Syndrome; Family; Family member; GWAS; Gene Targeting; Gene Transcription; Generalized Growth; Genes, Adenomatous Polyposis Coli; Genes, Reporter; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetics, in situ Hybridization; Growth; Growth and Development; Growth and Development function; HCT 116 Cells; HCT116; HCT116 Cells; HT-29; HT-29 Cells; HT29 Cells; Hereditary Adenomatous Polyposis Coli; Histology; Histone Acetylase; Homeostasis; IHC; Immigrations; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; In-Migration; Injections, Subcutaneous; Intermediary Metabolism; Intestinal; Intestines; Intracellular Communication and Signaling; Kinetic; Kinetics; Label; Large Intestine Carcinoma; Lead; Ligand Binding Domain; METBL; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Processes; Metabolism; Mice, Athymic; Mice, Nude; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Motility; Motility, Cellular; Mouse Strains; Mutate; Mutation; Nuclear; Nude Mice; P1-450; P450-C; P450DX; P450D\X; Pathogenesis; Pathway interactions; Pb element; Phenotype; Physiological Homeostasis; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Process; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Proteins; RNA Expression; RNA, Small Interfering; Reactive Site; Regulation; Reporter Genes; SEQ-AN; Sequence Analyses; Sequence Analysis; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Somatic Cell Genetics; Subcutaneous Injections; Targetings, Gene; Technology; Testing; Time; Tissue Growth; Transcription; Transcription Factor AP-1; Transcription, Genetic; Tumorigenicity; Uridine, 5-bromo-2'-deoxy-; activating transcription factor; adeno associated virus group; biological signal transduction; bowel; c myc; c-myc Genes; carcinogenesis; cell motility; cell type; chromatin immunoprecipitation; chromatin remodeling; conformation; conformational state; cultured cell line; familial adenomatous polyposis; familial polyposis; gastrointestinal; gene product; genetic promoter element; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; histone acetyltransferase; homologous recombination; in situ Hybridization Staining Method; in vivo; insight; malignancy; member; metaplastic cell transformation; neoplasm/cancer; ontogeny; pathway; recombinase; siRNA; tissue fixing; transcription factor; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog; whole genome association studies; whole genome association study","c-Myc transcription in intestinal growth, differentiation, and carcinogenesis",,80805,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,,4,307098,
7753860,R01,DK,5,,01/01/2010,12/31/2010,PA-07-026,5R01DK080823-02,,NIDDK:402209;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"WELLS, JAMES M;ZORN, AARON M (contact);",1928402;6955565 (contact);,5R01DK080823,01/01/2009,12/31/2012,"Anaplastic; Anterior; Bile; Bile Juice; Bile fluid; Blood Proteins; Body Tissues; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cardiac; Catenin, Beta-1; Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cellular Adhesion; D-Glucose; DNA Synthesis Factor; Data; Defect; Development; Dextrose; Disease; Disorder; Dose; Drug Metabolic Detoxication; ECGF; ES cell; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endocrine; Endoderm; Endothelial Cell Growth Factor; Event; Exhibits; Exocrine Glands; FGF; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Foregut; Gastrula; Gene Expression; Generations; Genetic; Genetic Algorithm; Genetic Programming; Glucose; Glycogen; Goals; Grafting, Liver; HBGF; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Hindgut; Human; Human, General; In Vitro; Intestinal; Intestines; Intracellular Communication and Signaling; Knock-out; Knockout; Knowledge; Lateral; Life; Ligands; Link; Liver; Liver Cells; Liver Transplant; Liver diseases; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mesoderm; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Methods; Mice; Modeling; Molecular; Morphogenesis; Murine; Mus; Operating System; Organ; PRO2286; Pathway interactions; Pattern; Phenotype; Primitive foregut structure; Publishing; Receptor Protein; Reporting; Repression; Research; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somites; Source; Staging; Testing; Time; Tissue Transplantation; Tissues; Translating; Translatings; Transplantation of liver; Transplantation, Hepatic; Undifferentiated; Xenopus; beta catenin; biological signal transduction; body system, hepatic; bowel; cell type; detoxification; disease/disorder; embryonic stem cell; experiment; experimental research; experimental study; hESC; hepatopathy; human ES cell; human ESC; human disease; human embryonic stem cell; insight; language translation; liver disorder; liver transplantation; monolayer; mutant; organ system, hepatic; pathway; progenitor; public health relevance; receptor; research study; response; social role; stem cell of embryonic origin",Mammalian Foregut and Liver Development, Narrative The liver is a vital organ providing many essential functions and numerous diseases are so life threatening that liver transplantation is the only option. The differentiation of liver cells from embryonic stem cells is a potentially renewable source of tissue for transplantation. The goal of this proposal is to elucidate the genetic programs controlling embryonic liver development in mice. We will then use this information to recapitulating the key embryonic events in human embryonic stem cells to more effectively generate liver tissue in culture.,80823,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,,2,402209,
7753861,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK080834-02,,NIDDK:362371;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,MEMPHIS,UNITED STATES,PHYSIOLOGY,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"NAREN, ANJAPARAVANDA P;",6478050;,5R01DK080834,01/01/2009,12/31/2012,"3'5'-cyclic ester of AMP; A Mouse; ABC Transport Protein; ABC Transporter Protein; ABC Transporters; ATP-Binding Cassette Transporters; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Agonist; Alimentary Canal; Amino Acids; Apical; Assay; Benemid; Benzoic acid, 4-((dipropylamino)sulfonyl)-; Bioassay; Biologic Assays; Biological Assay; C-terminal; Cell membrane; Cells; Chemosensitization; Chemosensitization/Potentiation; Chloride; Chloride Ion; Chlorides; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Cl- element; Complex; Complexes, Macromolecular; Coupled; Coupling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotides; Cytoplasmic Membrane; Diarrhea; Diffusion; Digestive Tract; Disease; Disorder; Enterocytes; Epithelial Cells; FRET; Fluorescence Resonance Energy Transfer; GI Tract; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gastrointestinal Tract; Gastrointestinal tract structure; Goals; HPLC; Health; Health Care Costs; Health Costs; Healthcare Costs; High Pressure Liquid Chromatography; Human; Human, General; In Vitro; Individual; Intestinal; Intestines; Knockout Mice; Laboratories; Lateral; Lead; Length; Life; Macromolecular Complexes; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Mediating; Membrane; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microscope; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Nucleotides, Cyclic; Null Mouse; PKA; Pb element; Peptides; Physiologic; Physiological; Plasma Membrane; Potentiation; Probenecid; Protein Kinase A; Regulation; Research; SK-Probenecid; Signal Pathway; Specificity; Surface; Tail; Testing; adenosine 3'5' monophosphate; alimentary tract; alpha Toxin; aminoacid; apical membrane; base; bowel; cAMP; cAMP-Dependent Protein Kinases; clinical relevance; clinically relevant; cross-link; crosslink; digestive canal; disease/disorder; experiment; experimental research; experimental study; gastrointestinal disorder; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; knock-down; membrane structure; molecular assembly; molecular assembly/self assembly; molecular self assembly; mouse model; particle; peptide C; plasmalemma; polypeptide C; protein protein interaction; public health relevance; research study; sensor; stoichiometry",Inhibition of an apical cAMP transporter (MRP4) in the gut induces diarrhea, PROJECT NARRATIVE: The proposed research will test the hypothesis that the two ABC transporters MRP4 (functions as cAMP transporter) and CFTR Cl- channel are physically and functionally coupled within the gut epithelial cell. This proposal will also test if inhibition of the MRP4 transporter function augments CFTR Cl- channel function thus potentiating cholera toxin (CTX) induced diarrhea in mice.,80834,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,,2,362371,
7772266,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK080996-02,,NIDDK:365904;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"BHUSHAN, ANIL ;",1908847;,5R01DK080996,02/15/2009,01/31/2014,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 21+ years old; Address; Adult; Age; Aging; Animals; B9 endocrine pancreas; Beta Cell; CAPS; Capsules; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Therapy; Cells; Cellular Proliferation; Control Locus; Data; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetic mouse; Doxycycline; Engraftment; Exocrine pancreas; Fostering; GWAS; Genes; Glucose Intolerance; Grafting, Islets of Langerhans; Human, Adult; Humulin R; In Vitro; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Islands of Langerhans; Islet Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Knockout Mice; Life; Light; Link; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Metabolic; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Molecular Target; Mother Cells; Murine; Mus; NIDDM; Natural regeneration; Nesidioblasts; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Pancreas, Endocrine; Pancreatic Islets; Pars endocrina pancreatis; Pathway interactions; Photoradiation; Physiologic; Physiological; Polycomb; Population; Production; Progenitor Cells; Proliferating; Proteins; Public Health; Regeneration; Regulation; Relative; Relative (related person); Repression; Role; Senescence; Stem cells; T2D; T2DM; Testing; Therapy, Cell; Transgenic Mice; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Transplantation, Pancreatic Islets; Type 2 diabetes; Type II diabetes; Urinary System, Kidney; Vibramycin; adult human (21+); adult onset diabetes; age dependent; age related; alpha-6-Deoxyoxytetracycline; beta cell development; capsule (pharmacologic); cell type; cell-based therapy; derepression; design; designing; diabetes; diabetic patient; endocrine pancreas; endocrine pancreas development; flexibility; gain of function; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; hematopoietic tissue; high risk; islet; islet beta cell transplantation; islet cell transplant; islet cell transplantation; islet development; islet progenitor; islet transplantation; ketosis resistant diabetes; maturity onset diabetes; medical complication; member; mouse model; mouse model of diabetes; novel therapeutic intervention; pathway; premature; public health medicine (field); public health relevance; regenerate; regenerative; renal; senescence; senescent; social role; whole genome association studies; whole genome association study",Role of polycomb group gene Bmi-1 in beta cell regeneration and aging," RELEVANCE TO PUBLIC HEALTH As diabetic patients require life-long insulin therapy and have a high risk of medical complications, preventative or curative therapies are urgently needed. Diabetes results from an inadequate mass of functional beta cells and there is increasing evidence to suggests that beta cell proliferation, the dominant means by which beta cells adapt to changing metabolic demands, is related to aging. This proposal contends that understanding the mechanisms of age-dependent beta cell expansion could be useful for regenerate beta cells and such an approach that exploits the mechanisms involved in the expansion of beta cell mass due to physiologic demands will be critical in developing novel therapeutic approaches that involve beta-cell regeneration in diabetic patients.",80996,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,2,365904,
7751212,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK081009-03,,NIDDK:334620;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"OZCAN, UMUT ;",9024810;,5R01DK081009,03/01/2008,12/31/2012,"Adenoviridae; Adenoviruses; Adipose tissue; Affect; Back; Butanoic Acids; Butyric Acids; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chaperone; Chemicals; Chiro-Inositol; Complex; Data; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dorsum; EC 2.7; Endoplasmic Reticulum; Enzymes; Epidemic; Ergastoplasm; Face; Fatty Tissue; Feedback; Generalized Growth; Genes; Genetically Engineered Mouse; Growth; Health; Human; Human, General; Humulin R; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IRS kinase; IRS-1 protein; IRS1; IRS2; IRS2 gene; Incidence; Individual; Injection of therapeutic agent; Injections; Inositol; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor Substrate 1; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; KIAA0243; Kinases; Knock-out; Knockout; L-Serine; Liver; METBL; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Mesoinositol; Metabolic Processes; Metabolism; Mice; Modality; Molecular; Molecular Chaperones; Murine; Mus; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Nutrient; Obesity; Pathology; Pathway interactions; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Turnover; Proteins; RAFT-1 gene product; Role; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; T2D; T2DM; TSC1; TSC1 gene; TSC1/2; TSC1/2 gene; TSC1/TSC2; TSC2; TSC2 gene; TSC2/TSC1; Tail; Tissue Growth; Transphosphorylases; Tsc1 [{C0694894}]; Tuberous sclerosis protein complex; Tumor Suppressor Proteins; Type 2 diabetes; Type II diabetes; Tyrosine Phosphorylation; Veins; adipose; adiposity; adult onset diabetes; base; biological signal transduction; body system, hepatic; c jun; c-jun Gene; cardiovascular disorder; corpulence; corpulency; corpulentia; cultured cell line; disease/disorder; effective therapy; endoplasmic reticulum stress; facial; feeding; gene product; high risk; improved; in vivo; insulin receptor serine kinase; insulin receptor substrate 1 protein; insulin resistant; insulin signaling; ketosis resistant diabetes; mTOR gene product; mTOR protein; mammalian target of rapamycin (mTOR); maturity onset diabetes; mouse model; new therapeutics; next generation therapeutics; novel therapeutic intervention; novel therapeutics; obese; obese people; obese person; obese population; ontogeny; organ system, hepatic; pathway; protein degradation; recombinase; response; sensor; social role; tuberous sclerosis complex; tumor suppressor; white adipose tissue; yellow adipose tissue",The In Vivo Role of JNK-1 and IRS-1 Ser307 Phosphorylation In Development of Insu,,81009,MCE,Molecular and Cellular Endocrinology Study Section,,3,334620,
7761765,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK081028-02,,NIDDK:257288;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,DURHAM,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"ILYASOVA, DORA ;",2220945;,5R01DK081028,02/01/2009,01/31/2012,"Active Follow-up; Age; Antioxidants; Archives; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; BMI percentile; BMI z-score; Body Weight decreased; Body mass index; Characteristics; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cohort Studies; Concurrent Studies; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Quality; Deterioration; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diagnosis; Disease Frequency Surveys; Early treatment; Epidemic; Epidemiology; F2-Isoprostanes; FLR; Failure (biologic function); Fats; Fatty acid glycerol esters; Foundations; Free Radicals; Future; Human; Human, General; Individual; Insulin Resistance; Intervention; Intervention Strategies; Life Style; Lifestyle; Link; MODY; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Metabolic; Methods; Muscle, Skeletal; Muscle, Voluntary; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Oxidative Stress; Pathogenesis; Pathway interactions; Persons; Pilot Projects; Population; Population Study; Prevention strategy; Preventive strategy; Publishing; Quality, Data; Quetelet index; Relative; Relative (related person); Reporting; Research; Research Design; Research Resources; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Sampling Studies; Skeletal Muscle Tissue; Skeletal muscle structure; Study Section; Study Type; Sum; Supplementation; T2D; T2DM; Testing; Time; Type 2 diabetes; Type II diabetes; Urinary System, Urine; Urine; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; adiposity; adult onset diabetes; anti-oxidant; atheromatosis; atherosclerotic vascular disease; base; biomarker; body weight gain; body weight increase; body weight loss; clinical investigation; cohort; corpulence; corpulency; corpulentia; design; designing; diabetes; diabetes risk; diabetic patient; disease prevention; disorder prevention; expectation; failure; follow-up; glucose tolerance; high risk; impaired glucose tolerance; improved; indexing; insulin resistant; interventional strategy; ketosis resistant diabetes; maturity onset diabetes; muscle metabolism; new approaches; novel; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; oxidation; pathway; pilot study; prevent; preventing; prospective; public health relevance; response; social role; study design; urinary; wt gain; wt-loss",Urinary F2-isoprostanes as a new biomarker for the risk of  type 2 diabetes," Type 2 diabetes is becoming a global epidemic with devastating consequences. Prevention of this disease is possible through lifestyle and pharmacological interventions. Therefore, there is an intensive effort to identify people at high risk. The proposed research offers an opportunity to develop a new biomarker, urinary levels of F2-IsoPs, which has the potential to predict the risk of diabetes beyond the known risk factors. Importantly, this biomarker is non-invasive and can be used in a clinical setting. We also believe that this biomarker can be used to predict weight gain, a very important characteristic for which no biomarkers are available.",81028,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",,2,257288,
7753209,R01,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R01DK081118-02,,NIDDK:540644;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,RICHMOND,UNITED STATES,OTHER HEALTH PROFESSIONS,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"SIMINOFF, LAURA A;",1876657;,5R01DK081118,01/01/2009,12/31/2012,"21+ years old; Adult; Affect; American; Area; Artificial Heart; Care, Health; Clinical, Transplantation, Organ; Communication; Consent; Dialysis; Dialysis procedure; ESRD; Education, Professional; Educational process of instructing; Effectiveness; Elements; End stage renal failure; End-Stage Kidney Disease; Evaluation; Experimental Designs; Family; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Grafting Procedure; Grafting, Kidney; HOSP; Health; Healthcare; Heart; Heart, Artificial; Hepatic Failure; Hospital Referrals; Hospitals; Human, Adult; Individual; Intervention; Intervention Strategies; Kidney Failure; Kidney Insufficiency; Kidney Transplantation; Kidney Transplants; Learning; Left; Literature; Liver; Liver Failure; Lung; MeSH Descriptors Class 4; Methods; Methods and Techniques; Methods, Other; Notification; Organ; Organ Donations; Organ Procurements; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Organ failure; Outcome; Participant; Patients; Play; Professional Education; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Referrals, Hospital; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal Transplantation; Renal Transplants; Renal dialysis; Research; Respiratory System, Lung; Role; Site; Solid; Source; System; System, LOINC Axis 4; Teaching; Techniques; Testing; Therapeutic; Time; Training; Transplant Recipients; Transplantation; Transplantation Surgery; United States; Waiting Lists; adult human (21+); artificial kidney dialysis; base; body system, hepatic; cardiac prosthesis; communication theory; cost; cost effective; design; designing; dialysis therapy; end-stage organ failure; geographic site; heart prosthesis; hospital organization; improved; intervention design; interventional strategy; kidney dialysis; mechanical heart; organ allograft; organ graft; organ system, hepatic; organ xenograft; programs; public health relevance; pulmonary; randomized trial; skills; social role; therapy design; transplant; transplant patient; treatment design; ventricular assist device",A Randomized Trial of the ERRA Intervention to Increase Consent to Organ Donation," There are over 96,000 patients on the transplantation waiting list but no more than a fraction of these patients will receive an organ transplant in any given year. This study proposes an intervention to help increase the rates of organ donation and alleviate the organ shortage.",81118,ZRG1,Special Emphasis Panel,,2,540644,
7773521,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK081644-02,,NIDDK:281398;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"JAIN, SANJAY ;",8110713;,5R01DK081644,02/20/2009,11/30/2012,"21+ years old; Acute; Acute Kidney Failure; Acute Renal Failure with Renal Papillary Necrosis; Adult; Affect; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Area; Biological; Biology; Body Tissues; Brain; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chronic; Clinical Trials, Therapy; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Dose; Economic Burden; Encephalon; Encephalons; Event; Family; Genes; Genetically Engineered Mouse; Genitourinary; Genitourinary system; Glean; Glia; Glial Cells; Health; Human; Human, Adult; Human, General; Idiopathic Parkinson Disease; Injury; Injury to Kidney; Intracellular Communication and Signaling; Ischemia-Reperfusion Injury; Kidney; Kidney Diseases; Kidney Failure; Kidney Failure, Acute; Kidney Insufficiency; Kidney Insufficiency, Acute; Knockout Mice; Kolliker's reticulum; Lead; Lewy Body Parkinson Disease; Ligands; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mesenchymas; Mesenchyme; Metanephric Diverticulum; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Murine; Mus; Natural regeneration; Neonatal; Nephropathy; Nervous System, Brain; Neural Crest; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Non-neuronal cell; Null Mouse; Organ System; PTK Receptors; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Patients; Pb element; Phenocopy; Physiologic; Physiological; Physiology; Primary Parkinsonism; Progenitor Cells; Proteins; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Regeneration; Renal Disease; Renal Failure; Renal Failure, Acute; Renal Insufficiency; Renal Insufficiency, Acute; Renal function; Reperfusion Damage; Reperfusion Injury; Reporter; Role; Scientist; Serologic; Serological; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Societies; Stem cells; Stress; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Effect; Therapeutic Trials; Therapy Clinical Trials; Time; Tissues; Toxin; Transgenic Mice; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Ureteric Bud; Urinary System, Kidney; Urogenital; Urogenital System; Wild Type Mouse; acute kidney injury; adult human (21+); base; biological signal transduction; body system; cell type; cultured cell line; disease/disorder; gene function; gene product; glial cell-line derived neurotrophic factor; heavy metal Pb; heavy metal lead; human disease; injured; insight; interest; kidney development; kidney disorder; kidney function; kidney preservation; model organism; mouse model; necrocytosis; nephrogenesis; nerve cement; neurodegenerative illness; neurotrophic factor; neurotrophin; neutrophin; novel; pathway; postnatal; progenitor; public health relevance; receptor; regenerate; renal; renal disorder; repair; repaired; response; social role; spatiotemporal; tool; urogenital system (urinary part)",DECIPHERING ROLES OF GDNF-GFRA1 RET SIGNALING IN NORMAL AND  INJURED KIDNEY, Narrative GDNF-Gfr¨1-Ret signaling pathway is critical for kidney development and regulates function of a number of tissue specific stem cells. In this proposal we will utilize novel animal models to modulate this pathway and determine its role in the function of postnatal kidney in normal and disease states and examine if treatment with GDNF can protect kidneys from renal failure. The studies will provide novel insights into mechanisms of repair and regeneration and therapy in injured kidneys.,81644,PBKD,Pathobiology of Kidney Disease Study Section,,2,281398,
7759113,R01,DK,5,,02/01/2010,01/31/2011,PA-07-016,5R01DK081750-02,,NIDDK:358495;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TEMPE,UNITED STATES,BIOLOGY,05,943360412,US,AZ,852873503,ARIZONA STATE UNIVERSITY-TEMPE CAMPUS,"YI, ZHENGPING ;",8755365;,5R01DK081750,02/01/2009,01/31/2013,"1-Phosphatidylinositol 3-Kinase; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Affect; Akt protein; Antibodies; Arts; Binding; Binding (Molecular Function); Biological Function; Biological Process; Biopsy; Blotting, Western; Cardiovascular Diseases; Co-Immunoprecipitations; Complex; Comprehension; Defect; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Gene Expression; Generations; Glycogen; Goals; Human; Human, General; Humulin R; IRS-1 protein; IRS1; Individual; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor Substrate 1; Insulin Resistance; Insulin Signaling Pathway; Insulin, Regular; Investigation; Laboratories; Lead; MODY; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Maturity-Onset Diabetes Mellitus; Methods; Microarray Analysis; Microarray-Based Analysis; Mitogenesis; Molecular; Molecular Interaction; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Obesity; Outcome; PDK1; PDPK1; PDPK1 gene; PI-3 Kinase; PI-3K; PI3-Kinase; PKB protein; PRO0461; Pathway interactions; Pattern; Pb element; Peptide Biosynthesis, Ribosomal; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Phosphorylation Site; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Positive Control of Cell Proliferation; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prevention; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase B; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Synthesis, Ribosomal; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteome; Proteomics; Proto-Oncogene Proteins c-akt; PtdIns 3-Kinase; RAC-PK protein; Relative; Relative (related person); Research; Signal Pathway; Signaling Protein; Skeletal Muscle Tissue; Skeletal muscle structure; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stable Isotope Labeling; Stimulation of Cell Proliferation; T2D; T2DM; Technology; Testing; Type 2 diabetes; Type I Phosphatidylinositol Kinase; Type II diabetes; Type III Phosphoinositide 3-Kinase; United States; Western Blotting; Western Blottings; Western Immunoblotting; Work; adiposity; adult onset diabetes; analog; base; c-akt protein; cardiovascular disorder; corpulence; corpulency; corpulentia; diabetic; disease/disorder; experiment; experimental research; experimental study; gene product; glucose transport; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; insulin receptor substrate 1 protein; insulin resistant; insulin signaling; interest; ketosis resistant diabetes; maturity onset diabetes; microarray technology; non-diabetic; nondiabetic; novel; obese; obese people; obese person; obese population; pathway; protein blotting; protein complex; protein protein interaction; protein synthesis; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; related to A and C-protein; research study; tandem mass spectrometry; tool; volunteer",Human Skeletal Muscle Proteome and Phosphoproteome in Obesity and Type 2 Diabetes," We propose to utilize innovative mass spectrometry based proteomic technology to study differences in protein-protein interactions and protein phosphorylation in the insulin signaling pathway in skeletal muscle from lean healthy, obese nondiabetic and type 2 diabetic volunteers. The overall goal of our research is to identify molecular mechanisms responsible for insulin resistance in human skeletal muscle and to provide novel targets for prevention and treatment of type 2 diabetes.",81750,CIDO,Clinical and Integrative Diabetes and Obesity Study Section,,2,358495,
7754038,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK082528-02,,NIDDK:344520;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BIRMINGHAM,UNITED STATES,BIOCHEMISTRY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"POPOV, KIRILL M;",1872356;,5R01DK082528,02/01/2009,01/31/2013,"Acute; Aerobic; Animal Model; Animal Models and Related Studies; Biochemical; C element; Carbamic acid, monoanhydride with phosphoric acid; Carbamoyl Phosphate; Carbamyl Phosphate; Carbohydrates; Carbon; Cells; Chronic; Citric Acid Cycle; Complex; Data; Dephosphorylation; Development; Diabetes Mellitus; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug or chemical Tissue Distribution; Energy Expenditure; Energy Metabolism; Enzymes; Fatty Acids; Goals; Impairment; Intermediary Metabolism; Ischemia; Isoenzymes; Isozymes; Krebs Cycle; METBL; Mammalia; Mammals; Mammals, General; Metabolic Pathway; Metabolic Processes; Metabolic acidosis; Metabolism; Mitochondria; Mitochondrial Matrix; Molecular; PDH Phosphatase; PDH kinase; Pathway interactions; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Play; Production; Property; Property, LOINC Axis 2; Protein Dephosphorylation; Protein Phosphorylation; Proteins; Proteomics; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Phosphatase; Pyruvate Dehydrogenase Phosphate Phosphatase; Reaction; Regulation; Role; Sepsis; Source; Starvation; Sterols; TCA cycle; Testing; Tissue Distribution; Tricarboxylic Acid Cycle; Work; adipogenesis; base; bloodstream infection; cholesterol biosynthesis; diabetes; disease/disorder; experiment; experimental research; experimental study; gene product; in vivo; lipid biosynthesis; lipogenesis; mitochondrial; model organism; oxidation; pathway; prevent; preventing; protein protein interaction; pyruvate dehydrogenase kinase; research study; social role; stem",Regulation of Energy Metabolism by PDP1 and PDP2,,82528,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,2,344520,
7767248,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK082582-02,,NIDDK:381150;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ITHACA,UNITED STATES,NUTRITION,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"QI, LING ;",9339877;,5R01DK082582,01/10/2009,11/30/2013,"ACRP30 protein; Adipocytes; Adipose Cell; Adipose tissue; Antidiabetic Hormone; Arts; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attention; Biochemical; Bone Marrow Transplant; Bone Marrow Transplantation; CRE Binding Protein; CREB; CREB Protein; CREB1; CREB1 gene; Calcineurin; Cancers; Cell Communication and Signaling; Cell Signaling; Chronic; Chronic Disease; Chronic Illness; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Cytosol; Data; Dephosphorylation; Development; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; EC 2.7; Event; Fat Cells; Fatty Tissue; Functional disorder; Future; GCG; Glucagon; Glucagon (1-29); Glukagon; Goals; Grafting, Bone Marrow; HG-Factor; Health; Hepatic Disorder; Human; Human, General; Humulin R; Hyperglycemic-Glycogenolytic Factor; INFLM; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinases; Link; Lipocytes; Liver diseases; Macrophage Activation; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mature Lipocyte; Mature fat cell; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic syndrome; Methods; Mice; Mice, Transgenic; Modeling; Molecular; Murine; Mus; NAFLD; NASH; Non-alcoholic steatohepatitis; Novolin R; Nuclear; Obesity; PP2B; Pathway interactions; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Physiopathology; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dephosphorylation; Protein Phosphatase-2B; Protein Phosphorylation; Proteins; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic; Thesaurismosis; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transducers; Transgenic Mice; Transphosphorylases; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adipose; adiposity; apM-1 protein; apM1 (adipose-specific) protein; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; chronic disease/disorder; chronic disorder; cofactor; corpulence; corpulency; corpulentia; cytokine; diabetes; diabetic patient; disease/disorder; gene product; glucose tolerance; hepatic gluconeogenesis; hepatopathy; insulin resistant; insulin sensitivity; interventional strategy; liver disorder; loss of function; macrophage; malignancy; metabolism disorder; mouse model; mutant; neoplasm/cancer; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; pathophysiology; pathway; public health relevance; resistin; response; social role; upstream kinase; white adipose tissue; yellow adipose tissue",Adipokine Signaling in Macrophages,,82582,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,2,381150,
7755899,R01,DK,5,,12/01/2009,11/30/2010,PA-07-070,5R01DK082723-02,,NIDDK:321235;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"HERZLINGER, DORIS A;",1902653;,5R01DK082723,01/15/2009,11/30/2013,"0-6 weeks old; Abscission; Alleles; Allelomorphs; Birth; Birth Defects; Bladder; Body Tissues; Causality; Cell Communication and Signaling; Cell Lineage; Cell Signaling; Cephalic; Characteristics; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cranial; Cues; DNA Recombination; DNA recombination (naturally occurring); Data; Defect; Development; Distal; Duct; Duct (organ) structure; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encapsulated; Epithelial; Etiology; Event; Excision; Exhibits; Extirpation; Fibroblasts; Fibrous capsule of kidney; Gene Copy Number; Gene Dosage; Genes; Genetic; Genetic Recombination; Genotype; Germ Lines; Human; Human, General; In Vitro; Infant, Newborn; Intracellular Communication and Signaling; Kidney; Knockout Mice; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Metanephric Diverticulum; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Molecular Genetic Abnormality; Morphogenesis; Murine; Mus; Muscle; Muscle Tissue; Muscle function; Muscle, Involuntary; Muscle, Smooth; Mutant Strains Mice; Nephrons; Newborn Infant; Newborns; Null Mouse; Obstruction; Obstructive Uropathy; Parturition; Pathway interactions; Pattern; Pelvic; Pelvic Region; Pelvis; Phenotype; Position; Positioning Attribute; Predisposition; Prevention; Process; Publishing; RNA, Messenger; Recombination; Recombination, Genetic; Regulation; Removal; Renal Capsule; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Smooth muscle (tissue); Staging; Surgical Removal; Susceptibility; System; System, LOINC Axis 4; Technology; Testing; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tube; Ureter; Ureteric Bud; Urinary System, Bladder; Urinary System, Kidney; Urinary System, Urine; Urinary tract; Urine; Uriniferous Tube; Waste Products; Work; biological signal transduction; cell type; cofactor; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; in vivo; insight; kidney development; knock-down; mRNA; mouse mutant; mutant; nephrogenesis; newborn human (0-6 weeks); pathway; prevent; preventing; progenitor; public health relevance; renal; research study; resection; social role; urinary bladder; urinary tract obstruction",Ureteric Bud Patterning," The ureter, a muscular tube that transports waste products from the kidneys to the bladder, is highly prone to congenital defects in humans. However, the mechanisms guiding ureter formation in the developing embryo remain poorly understood. In this proposal, we will test several hypotheses explaining the susceptibility of this urinary tract segment to defects.",82723,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,2,321235,
7778871,R01,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R01DK082773-02,,NIDDK:365904;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,INDIANAPOLIS,UNITED STATES,PHYSIOLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"ELMENDORF, JEFFREY S;",1920411;,5R01DK082773,03/15/2009,01/31/2013,"(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase; 5'-AMP-activated protein kinase; ADD-1 protein; ADD1 protein; AMP-activated kinase; AMP-activated protein kinase; AMPK enzyme; Abscission; Acid, Phosphatidic; Acute; Anabolism; Animal Model; Animal Models and Related Studies; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Attention; B-Protein; Biochemical; Biology; Catalase B; Causality; Cell Components; Cell Structure; Cell membrane; Cellular Structures; Characteristics; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chronic; Clinical; CoA; Coenzyme A; Common Rat Strains; Country; Coupled; Cultured Cells; Cytoplasmic Membrane; Data; Defect; Dehydrogenases; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Distal; Docking; Educational process of instructing; Employee Strikes; Endoplasmic Reticulum; Ergastoplasm; Etiology; Event; Excision; Exercise; Exercise, Physical; Extirpation; F-Actin; Fats; Fatty Acids, Nonesterified; Fatty acid glycerol esters; Filamentous Actin; Free Fatty Acids; GLUT4; GLUT4 gene; Gene Transcription; Genetic Transcription; Glucose Binding Protein; Glucose Transporter; Glycoprotein 75; Goals; HMG CoA reductase (NADPH) kinase; HMG CoA reductase kinase; HMG coenzyme A reductase (NADPH) kinase; Hexosamines; Humulin R; Hyperglycemia; Hyperinsulinemia; Hyperinsulinism; Hyperlipemia; Hyperlipidemia; INSR; In Vitro; Individual; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin Resistance; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Investigation; Lead; Link; Lipids; MODY; Mammals, Rats; Maturity-Onset Diabetes Mellitus; Medicine; Membrane; Membrane Fusion; Metabolic Glycosylation; Molecular; Muscle; Muscle Fibers; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Myotubes; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Novolin R; Obesity; Operation; Operative Procedures; Operative Surgical Procedures; Oxidoreductase; PIP2; Pathway interactions; Pb element; Peripheral; Phenotype; Phosphatides; Phosphatidic Acid; Phosphatidyl Inositol; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphoinositides; Phospholipids; Physiologic; Physiological; Plasma Membrane; Population; PtIns 4,5-P2; PtdIns; PtdInsP2; Publishing; RNA Expression; Rat; Rattus; Receptor Signaling; Reductases; Regulation; Removal; Research; Rhabdomyocyte; SREBP-1c; Science of Medicine; Secondary to; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Stimulus; Strikes; Strikes, Employee; Structure; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Syndrome; System; System, LOINC Axis 4; T2D; T2DM; TRP-1; TYRP; TYRP1; TYRP1 protein, human; Teaching; Testing; Therapeutic; Therapeutic Intervention; Transcription; Transcription, Genetic; Translating; Translatings; Transport Protein, Glucose; Type 2 diabetes; Type II diabetes; Tyrosinase-Related Protein 1; VESCL; Vesicle; adiposity; adult onset diabetes; anti-diabetic drugs; antidiabetic; base; biosynthesis; blood glucose regulation; brown locus protein, human; corpulence; corpulency; corpulentia; cost; diabetes; disease causation; disease etiology; disease/disorder etiology; disorder etiology; glucose control; glucose homeostasis; glucose regulation; glucose transport; glucose uptake; glycoprotein-75, human; glycosylation; gp75 TRP-1, brown protein, human; heavy metal Pb; heavy metal lead; human TYRP1 protein; hydroxymethylglutaryl-CoA-reductase kinase; hyperglycemic; improved; in vivo; insulin resistant; insulin secretion; insulin sensitivity; interest; intervention therapy; ketosis resistant diabetes; language translation; maturity onset diabetes; melanoma antigen gp75, human; membrane structure; model organism; new therapeutics; next generation therapeutics; novel therapeutics; obese; obese people; obese person; obese population; pathway; plasmalemma; public health relevance; resection; surgery; theories; therapeutic target; transcription factor; transcription factor ADD1; tyrosinase-related protein 1, human",Mechanisms of Membrane-Based Insulin Resistance & Therapeutic Reversal Strategies," Project Narrative Solving how insulin resistance develops and eventually progresses/worsens to type 2 diabetes (T2D) remains a fundamental challenge in biology and a significant issue in medicine. Our studies have discovered that the breakdown of glucose homeostasis, characteristic of obesity and T2D, is secondary to plasma membrane cholesterol accrual in fat and muscle. We have also identified means to protect against this derangement, and further investigation of the mechanisms involved will hopefully lead to new therapeutic strategies to curtail the accelerated expansion of the T2D population.",82773,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,2,365904,
7759149,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB000343-09,,NIBIB:332357;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,TUCSON,UNITED STATES,NONE,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"TROUARD, THEODORE P;",1872579;,5R01EB000343,04/02/2001,01/31/2011,"3 alpha-Hydroxy-5 alpha-pregnan-20-one; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one; Age; Allopregnanolone; Anabolism; Animal Model; Animal Models and Related Studies; Animals; Anisotropy; Ataxia; Ataxy; Body Weight decreased; Brain; Brain imaging; Brain region; Case Study; Cessation of life; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coordination Impairment; Death; Defect; Development; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disease Progression; Disorder; Dyssynergia; Encephalon; Encephalons; Evaluation; Funding; Future; Gangliosides; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glia; Glial Cells; Goals; Grant; Hereditary; Histology; Human; Human, General; Hydrogen Oxide; Image; Imaging Procedures; Imaging Techniques; Individual; Inherited; Intervention; Intervention Strategies; Investigation; Kolliker's reticulum; Life; Longitudinal Studies; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Method LOINC Axis 6; Methodology; Methods; Mice; Mice, Transgenic; Molecular; Monitor; Murine; Mus; Mutation; Myelin; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurological Disorders; Neuron Degeneration; Neurons; Non-neuronal cell; Nuclear Magnetic Resonance Imaging; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Pathology; Patients; Pattern; Performance; Physiologic; Physiological; Pregnanolone, (3alpha,5alpha)-isomer; Principal Investigator; Relaxation; Research; Sialoglycosphingolipids; Staging; Technics, Imaging; Testing; Therapeutic; Therapy Evaluation; Time; Transgenic Mice; Transgenic Organisms; Translations; Water; Weight; Weight Loss; Weight Reduction; Work; Zeugmatography; biomarker; biosynthesis; body weight loss; brain visualization; case report; clinical investigation; design; designing; diffusion tensor imaging; disease natural history; disease/disorder; drug development; early childhood; effective therapy; efficacy evaluation; end stage disease; experiment; experimental research; experimental study; ganaxolone; genome mutation; imaging; imaging modality; interventional strategy; long-term study; model organism; mouse model; myelination; natural history of disease; nerve cement; nervous system disorder; neural degeneration; neurodegeneration; neurological disease; neuromuscular; neuronal; neuronal degeneration; neurosteroids; non-invasive monitor; novel; research study; response; substantia alba; therapeutic target; trafficking; transgenic; water diffusion; white matter; wt-loss",Non-Invasive Monitoring of NPC Disease Progression and Therapy,,343,MEDI,Medical Imaging Study Section,,9,332357,
7759565,R01,EB,5,,02/01/2010,01/31/2011,PA-07-070,5R01EB000708-08,,NIBIB:327428;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CHAPEL HILL,UNITED STATES,CHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"SCHOENFISCH, MARK H;",2098705;,5R01EB000708,09/25/2002,01/31/2012,"Animal Model; Animal Models and Related Studies; Anti-Bacterial Agents; Antibacterial Agents; Bacterial Adhesion; Bacterial Infections; Biocompatible; Biosensor; Blood flow; Body Tissues; CAPS; Capsules; Characteristics; Chemistry; Clinical; Cristobalite; D-Glucose; Data; Development; Devices; Dextrose; Diabetes Mellitus; Diffusion; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Evaluation; Exhibits; Family suidae; Fascia, Superficial; Film; Foreign Bodies; Funding; Glucose; Goals; Histology; Hypodermis; INFLM; Implant; In Vitro; Incidence; Infection; Inflammation; Inflammatory Response; Knowledge; Lead; Measures; Membrane; Microbial Biofilms; Microdialysis; Modeling; Mononitrogen Monoxide; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nitric Oxide; Nitric Oxide Donors; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Ostamer; Patients; Pb element; Pellethane; Performance; Permeability; Phagocytosis; Physiologic; Physiological; Pigs; Polyisocyanates; Polyurethanes; Population; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; QOC; Quality of Care; Research; Role; Sand; Science of Chemistry; Silica; Silicon Dioxide; Site; Solutions; Subcutaneous Tissue; Subcutis; Suidae; Swine; Tela Subcutanea; Thick; Thickness; Thrombosis; Tissues; Transducers; Tridymite; United States National Institutes of Health; Vascularization; Work; Wound Healing; Wound Repair; abstracting; angiogenesis; anti-bacterial; antibacterial; bacterial disease; base; biocompatibility; biofilm; biomaterial compatibility; capsule (pharmacologic); controlled release; cytokine; design; designing; diabetes; diabetic patient; endothelial cell derived relaxing factor; glucose meter; glucose monitor; glucose sensor; heavy metal Pb; heavy metal lead; implantation; improved; in vivo; membrane structure; model organism; monitoring device; nano particle; nanoparticle; new approaches; next generation; novel; novel approaches; novel strategies; novel strategy; porcine; prevent; preventing; programs; response; scaffold; scaffolding; sensor; sensor (biological); social role; subcutaneous; suid; tissue repair",Nitric Oxide-Releasing Glucose Biosensors,,708,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,8,327428,
7790740,R01,EB,5,,02/01/2010,01/31/2011,PA-07-070,5R01EB001480-07,,NIBIB:352841;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,NEW YORK,UNITED STATES,BIOLOGY,15,049179401,US,NY,100277003,COLUMBIA UNIV NEW YORK MORNINGSIDE,"SHEETZ, MICHAEL PATRICK;",1883107;,5R01EB001480,02/15/2003,01/31/2013,"280 kDa actin-binding protein; ABP 280; ATP[{..}]protein-tyrosine O-phosphotransferase; Actinin; Actins; Adhesion Plaques; Adhesions; Antibodies; Assay; BCAR1 Protein; BCAR1 protein, human; Band 2 Protein; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Breast Cancer Anti-Estrogen Resistance 1 Protein; C-terminal; CKRAS protein; CRK-Associated Substrate; Cancer of Breast; Cancers; Cardiovascular Diseases; Cas protein; Cell Communication and Signaling; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell-Matrix Adherens Junctions; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Cessation of life; Cold-Insoluble Globulins; Combining Site; Complex; Crk-associated substrate, human; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Death; Dependence; Development; Disease; Disorder; Dissociation; EC 2.7; EP-20 protein, human; EP20 protein, human; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; ESP BE-20 protein, human; Environment; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Event; Extracellular Matrix, Integrins; Eye; Eyeball; FADK; FAK; FAK1; FN1; FNZ; Fibronectin 1; Fibronectins; Fluorescence Microscopy; Focal Adhesions; Focal Contacts; Generalized Growth; Genetics-Mutagenesis; Goals; Growth; HEK3; In Vitro; Integrins; Intracellular Communication and Signaling; Kinases; L-tyrosine, dihydrogen phosphate (ester); LETS Proteins; Large External Transformation-Sensitive Protein; Ligand Binding Protein; Ligands; Link; Location; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measurement; Measures; Mechanics; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Modeling; Models, Molecular; Molecular; Molecular Biology, Mutagenesis; Molecular Dynamics Simulation; Molecular Interaction; Molecular Models; Motility; Motility, Cellular; Muscle Rigidity; Mutagenesis; Natural regeneration; Nucleic Acid Biochemistry, Molecular Modeling; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Organ; Organism; P130 platelet protein, human; P130 protein, human; P130Cas protein, human; PTK; PTK2; PTK2 gene; PTP-1B; PTP-PEST; PTP1B; PTPG1; PTPN1; PTPN1 gene; PTPN12; PTPN12 gene; Pathway interactions; Peptide Domain; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Plasma Membrane; Position; Positioning Attribute; Process; Protein Domains; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Reactive Site; Regeneration; Relative; Relative (related person); Rigidity; Rigidity, Muscular; Signal Transduction; Signal Transduction Systems; Signaling; Stretching; Subcellular Process; Substrate Domain; Talin; Technology; Tertiary Protein Structure; Testing; Time; Tissue Growth; Tissues; Transphosphorylases; Tyrosine Kinase; Tyrosine Phosphorylation; Tyrosine-O-phosphate; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; VCL; Vinculin; Vinculin (Caenorhabditis elegans clone pRB9.1 protein moiety reduced); ZYX protein, human; alpha 2-Surface Binding Glycoprotein; alpha helix; base; biological signal transduction; breast cancer anti-estrogen resistance 1, human; cancer cell; cardiovascular disorder; cell growth; cell motility; cell transduction; cellular transduction; disease/disorder; epididymal protein, 20 kDa, human; epididymis-specific protein BE-20, human; experiment; experimental research; experimental study; filamin; filamin 1; filamin A; fluorophore; gene product; human BCAR1 protein; human ZYX protein; hydroxyaryl protein kinase; in vivo; interest; intracellular skeleton; living system; magnetic beads; malignancy; malignant breast neoplasm; molecular dynamics; molecular modeling; neoplasm/cancer; novel; ontogeny; p130 Crk-associated substrate protein, human; p130 cas protein; p130CAS; pathway; plasmalemma; pp125FAK; public health relevance; regenerate; research study; response; sensor; single molecule; transduced cells; tyrosyl protein kinase; zyxin; zyxin protein, human",Mechanisms of mechanical transduction by cytoskeletons, Cell responses to local force and geometry give rise to the final form of the tissue and the organism; but underlie many diseases including cancer and cardiovascular disease. We have determined that the cell cytoskeleton transduces force into biochemical signals in the absence of a plasma membrane through stretch-dependent activation of tyrosine phosphorylation that is related to transformation in cancer. We plan to characterize the molecular mechanisms by which force and stretch are converted into relevant biochemical signals with an eye for novel ways to treat disease or aiding regeneration.,1480,CSF,Cell Structure and Function Study Section,,7,352841,
7764754,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB001567-08,,NIBIB:339274;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CHARLOTTESVILLE,UNITED STATES,BIOCHEMISTRY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"EGELMAN, EDWARD H.;",1867322;,5R01EB001567,02/01/2003,01/31/2011,"ATPase, Actin-Activated; Actins; Address; Adenosine Triphosphatase, Myosin; Algorithms; Antibiotic Resistance; Area; Bacterial Conjugation; Bacterial Meningitis; Bacteriophages; Biological; Biological Models; Biology; Caliber; Categories; Cells; Clinical; Cloning Vectors; Collaborations; Communicable Diseases; Complement; Complement Proteins; Complexes, Macromolecular; Computer Programs; Computer software; Conflict; Conflict (Psychology); Conjugation, Genetic; Development; Diameter; Disease; Disorder; EPEC; Electron Microscope; Electrons; Familiarity; Fiber; Filament; Filamentous Bacteriophages; Flagella; Flagellin; Funding; Generations; Genetic Conjugation; Gonococcal Infection; Gonococcus; Gonorrhea; Heterogeneity; Image; Image Analyses; Image Analysis; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inovirus; Integral Membrane Protein; Intrinsic Membrane Protein; Investigators; Laboratories; Lead; Lipids; Location; Macromolecular Complexes; Meningitis; Meningitis, Bacterial; Methods; Microscopic; Model System; Modeling; Models, Biologic; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; N. gonorrhoeae; N.gonorrhoeae; NIH; National Institutes of Health; National Institutes of Health (U.S.); Needles; Negative Beta Particle; Negatrons; Neisseria gonorrhoeae; Organism; Pathogenesis; Pb element; Phage Display; Phages; Pilum; Polymers; Population; Procedures; Programs (PT); Programs [Publication Type]; Proteins; ROC Analysis; Research; Research Personnel; Research Specimen; Researchers; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Resolution; Software; Specimen; Spiders; Structure; System; System, LOINC Axis 4; Testing; Time; Transmembrane Protein; Tube; Tubulin; Type III Secretion System; Type III Secretion System Pathway; United States National Institutes of Health; antibiotic resistant; bacterial virus; base; computer program/software; disease/disorder; enteropathogenic E. coli; enteropathogenic E.coli; enteropathogenic Escherichia coli; experience; falls; fimbriae; gene product; heavy metal Pb; heavy metal lead; image evaluation; imaging; improved; insight; interest; living system; macromolecule; method development; muscular structure; myosin ATP phosphohydrolase (actin translocating); pathogenic bacteria; pilus; prevent; preventing; programs; protein structure; reconstruction; software systems; solid state nuclear magnetic resonance; structural biology; tool; user-friendly",Methods for the Analysis of Helical Macromolecular Complexes,,1567,MI,Microscopic Imaging Study Section,,8,339274,
7787469,R01,EB,5,,02/01/2010,01/31/2011,PA-07-070,5R01EB001963-26,,NIBIB:340808;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,FARMINGTON,UNITED STATES,BIOCHEMISTRY,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"LOEW, LESLIE M;",1867326;,5R01EB001963,09/01/1984,01/31/2013,"Action Potentials; Address; Beds; Biochemical; Biological; Biology; Body Tissues; Brain; Cardiac; Cell Communication and Signaling; Cell Membrane Permeability; Cell Signaling; Cells; Chemicals; Chemistry; Collaborations; Collection; Coloring Agents; Communities; Contrast Agent; Contrast Drugs; Contrast Media; Dendrites; Dendritic Spines; Development; Dyes; Electromagnetic, Laser; Electronics; Electrophysiology; Electrophysiology (science); Employee Strikes; Encephalon; Encephalons; F element; Feedback; Fluorescence; Fluorine; Generations; Grant; Heart; History; Illumination; Image; Intracellular Communication and Signaling; Kinetic; Kinetics; Knowledge; Laboratories; Lasers; Lead; Life; Lighting; Measurement; Measures; Membrane; Membrane Potentials; Methods; Modality; Morphology; Msec; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Neurosciences; Optics; Pattern; Pb element; Photons; Position; Positioning Attribute; Preparation; Property; Property, LOINC Axis 2; Purkinje Cells; Purkinje's Corpuscles; Radiation, Laser; Radiopaque Media; Reaction Time; Recording of previous events; Research; Resolution; Response RT; Response Time; Resting Potentials; Role; Sampling; Science of Chemistry; Signal Transduction; Signal Transduction Systems; Signaling; Speed; Speed (motion); Spinal Column; Spine; Staining method; Stainings; Stains; Strikes; Strikes, Employee; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Technology; Testing; Tissues; Transmembrane Potentials; V (voltage); Vertebral column; backbone; base; biological signal transduction; cerebellar Purkinje cell; chromophore; dendrite spine; design; designing; electrical property; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; imaging; improved; information processing; light intensity; meetings; membrane permeability; membrane structure; method development; millisecond; molecular rearrangement; neuronal; new technology; postsynaptic; preparation (biological); psychomotor reaction time; public health relevance; research study; response; second harmonic; social role; success; technology development; voltage",Potentiometric Dyes and Membrane Permeability, This project will develop new functional contrast agents that will permit the imaging of electrical activity in excitable tissue with sub-cellular resolution. This technology will be applied to the study of normal and diseased heart. It will also be used to understand information processing in the brain at the level of a single synapse.,1963,MI,Microscopic Imaging Study Section,,26,340808,
7779474,R01,EB,5,,02/01/2010,01/31/2011,PAR-07-344,5R01EB003150-28,,NIBIB:434449;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,ITHACA,UNITED STATES,CHEMISTRY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"FREED, JACK H;",1864735;,5R01EB003150,12/01/1978,01/31/2013,"(11)Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-; 2-dimensional; A 23187; A23187; ATGN; Actins; Address; Alamethicin; Allergic; Amino Acids; Antibiotic A23187; Antigens; Arteriosclerosis; Binding; Binding (Molecular Function); Biological Function; Biological Models; Biological Process; Blood Coagulation Factor IV; CD 23 Antigens; CD23 Antigens; Ca++ element; Calcium; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Membrane Lipids; Cell Membrane Proteins; Cell Signaling; Cell membrane; Cell-to-Cell Interaction; Cells; Charge; Chemoreceptors; Chemotaxis; Chimera Protein; Chimeric Proteins; Cholest-5-en-3-ol (3beta)-; Cholesterol; Coagulation Factor IV; Collaborations; Companions; Complex; Cytochalasin D; Cytoplasmic Membrane; Data; Dephosphin; Detection; Detergents; Disease; Disorder; Dynamin; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Electrons; Electrostatics; Factor IV; Frequencies (time pattern); Frequency; Fusion Protein; HPC-1 protein; Head; Health; Hemagglutinin; Human; Human, General; Idiopathic Parkinson Disease; IgE Receptors; Immune response; Immunoglobulin E Receptor; Individual; Influenza Virus; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Investigation; Ionophores; Lead; Length; Lewy Body Parkinson Disease; Life; Link; Lipid Bilayers; Lipids; Liquid substance; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane; Membrane Fusion; Membrane Lipids; Membrane Proteins; Membrane-Associated Proteins; Methods; Micelles; Model System; Modeling; Models, Biologic; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; NAC precursor; Negative Beta Particle; Negatrons; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; PARK1 protein; PARK4 protein; Paralysis Agitans; Paramagnetic Resonance; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pb element; Peptides; Physiologic pulse; Plasma Membrane; Prevention; Primary Parkinsonism; Process; Property; Property, LOINC Axis 2; Protein Conformation; Proteins; Proteins, Cell Membrane; Pulse; Receptor Activation; Receptor Protein; Receptors, IgE; Relaxation; Research; Resistance; SNCA; SNCA protein; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Spectroscopy, ESR; Spin Labels; Spinal Column; Spine; Structure; Surface Proteins; Technology; Testing; Thick; Thickness; Transmembrane Protein; VESCL; Vertebral column; Vesicle; Viral; Work; alpha synuclein; alphaSP22; aminoacid; amphiphysin; backbone; base; biological signal transduction; clinical applicability; clinical application; conformation; conformational state; cross-link; crosslink; disease/disorder; electron paramagnetic resonance spectroscopy; epsilon Fc Receptors; experiment; experimental research; experimental study; fluid; gene product; gramicidin A; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; in vivo; influenzavirus; influenzavirus (unspecified); insight; lipid bilayer membrane; liquid; membrane model; membrane structure; molecular dynamics; mutant; nervous system disorder; neurological disease; neuronal cell membrane antigen, HPC-1; non A-beta component of AD amyloid; non A4 component of amyloid precursor; plasmalemma; polymerization; protein structure; public health relevance; receptor; research study; resistant; response; success; synaptobrevin; syntaxin 1A; synuclein; two-dimensional; vesicle-associated membrane protein",Electron Spin Relaxation in Model Membranes," Project Narrative We are studying structures of proteins and cell membranes, as well as the way proteins interact with other components of cell membranes, such as lipids and cholesterols. Our study will focus on understanding mechanisms by which cells communicate with each other through exchange of cellular components. Disorder in the structure of the proteins and the manner of cell communication may lead to allergic conditions, arteriosclerosis, Parkinson's and other diseases.",3150,ZRG1,Special Emphasis Panel,,28,434449,
7760660,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB005692-04,,NIBIB:355630;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,BALTIMORE,UNITED STATES,BIOMEDICAL ENGINEERING,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"YAREMA, KEVIN J;",7740388;,5R01EB005692,04/01/2007,01/31/2011,"21+ years old; Adhesions; Adult; Arm; Au element; Behavior; Binding; Binding (Molecular Function); Biochemical; Carbohydrates; Cell Adhesion; Cell Coat; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell surface; CellLine; Cells; Cellular Adhesion; Characteristics; Chemicals; Chemistry; Common Rat Strains; Communities; Complex; Cues; Custom; Dependence; Dose; ES Cell Line; Embryonic Stem Cell Line; Engineering; Engineerings; Evaluation; Foundations; G-Protein Signaling Pathway; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Expression; Generalized Growth; Genes; Genetic Models; Glass; Glycocalyx; Goals; Gold; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Human, Adult; Intercept; Intracellular Communication and Signaling; Investigators; JNK; JNK1; JNK1A2; JNK21B1/2; Laboratories; Lead; Length; Life; Link; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Maleimides; Mammalian Cell; Mammals, Rats; Mediating; Mercaptans; Mercapto Compounds; Messenger RNA; Metabolic; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Models, Genetic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mother Cells; N-Acetylneuraminic Acids; N-acetylmannosamine; Nano-topography; Nanotopography; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Pathways; Neurocyte; Neurons; Nucleus; Oligosaccharides; Outcome; Oxidation-Reduction; PRKM8; Pathway interactions; Pattern; Pb element; Pilot Projects; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; RNA, Messenger; Rat; Rattus; Receptor Protein; Redox; Research; Research Personnel; Researchers; SAPK1; Science; Science of Chemistry; Sialic Acids; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway from G-Protein Families; Solid; Staging; Stem cells; Sulfhydryl Compounds; Surface; Suspension substance; Suspensions; Techniques; Technology; Testing; Thiols; Time; Tissue Engineering; Tissue Growth; Upper arm; Walking; adult human (21+); adult stem cell; analog; base; biological signal transduction; biomaterial interface; cell type; chemical property; cross-link; crosslink; cultured cell line; density; design; designing; disulfide bond; engineered tissue; experience; functional group; gene product; hESC; heavy metal Pb; heavy metal lead; human ES cell; human ESC; human embryoid body; human embryonic stem cell; innovate; innovation; innovative; mRNA; nano fiber; nanofiber; nanofibrous; neural; neuronal; novel; ontogeny; oxidation reduction reaction; particle; pathway; pilot study; programs; receptor; relating to nervous system; response; scaffold; scaffolding; small molecule; stem; stem cell fate; sugar; sulfhydryl group; suspension; tool",Engineering a Carbohydrate-Biomaterial Interface for Control of Wnt Signaling and,,5692,BMBI,Biomaterials and Biointerfaces Study Section,,4,355630,
7753644,R01,EB,5,,12/01/2009,11/30/2010,PA-02-011,5R01EB006179-04,,NIBIB:325832;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,ATLANTA,UNITED STATES,ENGINEERING (ALL TYPES),05,097394084,US,GA,303320420,GEORGIA INSTITUTE OF TECHNOLOGY,"DEWEERTH, STEPHEN P;",6924493;,5R01EB006179,02/15/2007,11/30/2010,"American; Axon; Behavior; Behavior Control; Behavioral Manipulation; Biocompatible; Brain; Bypass; Coloring Agents; Common Rat Strains; Computational Technique; Connector Neuron; Deterioration; Development; Devices; Disease; Disorder; Dyes; Electrodes; Elements; Encephalon; Encephalons; Engineering; Engineerings; Frequencies (time pattern); Frequency; Generations; In Vitro; Individual; Injury; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Investigators; Knowledge; Label; Life; Location; Locomotion; Locomotor Activity; Mammals, Rats; Maps; Medulla Spinalis; Modeling; Motor; Motor Activity; Motor output; Movement; Myelopathy, Traumatic; Neonatal; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Output; Palsy; Paralysed; Pathway interactions; Pattern; Physiologic; Physiological; Plegia; Population; Preparation; Prosthesis; Prosthetic device; Prosthetics; QOL; Quality of life; Rat; Rattus; Recruitment Activity; Research; Research Personnel; Researchers; SCI Patients; Sensory; Site; Speed; Speed (motion); Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Spinal cord injury patients; Stimulus; Surface; System; System, LOINC Axis 4; Technology; Testing; Time; Walking; Work; base; behavioral control; body movement; central pattern generator; clinical relevance; clinically relevant; design; designing; disease/disorder; experiment; experimental research; experimental study; improved; motor control; neural; neuronal; novel; paralysis; paralytic; pathway; recruit; relating to nervous system; research study; response; restoration; sensorimotor system; sensory feedback; sensory motor system; spatiotemporal; spinal tract; substantia alba; technology/technique; tool; white matter",Closed-Loop Control of Spinal Motor Circuits using a Multi-electrode Interface,,6179,ZRG1,Special Emphasis Panel,,4,325832,
7774995,R01,EB,5,,03/01/2010,02/28/2011,PA-02-011,5R01EB006353-04,,NIBIB:453645;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,LOS ANGELES,UNITED STATES,CHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"WEISS, SHIMON ;",1988553;,5R01EB006353,04/01/2007,02/28/2011,"3-D; 3-Dimensional; Analysis, Data; Animals; Anisotropy; Anodes; Arts; Behavior; Biochemical; Biological; Biology; Biophysics; Body Tissues; Caliber; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Charge; Complex; Computer Programs; Computer software; Data; Data Analyses; Detection; Development; Devices; Diagnosis; Diameter; Dimensions; Disease; Disorder; Electromagnetic, Laser; Electronics; Elements; Event; Evolution; FRET; Fluorescence; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; Fluorescence Spectroscopy; Future; GaAs; Generations; Height; Human; Human, General; Image; Instrumentation, Other; Interdisciplinary Research; Interdisciplinary Study; Intracellular Communication and Signaling; Investigators; Lasers; Lead; Life; Man (Taxonomy); Man, Modern; Measures; Medical; Medicine; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microfluidic; Microfluidics; Microscopic; Microscopy; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mission; Molecular; Molecular Probes; Monitor; Multidisciplinary Collaboration; Multidisciplinary Research; NIGMS; NIH Program Announcements; National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; Noise; Patients; Pb element; Performance; Photons; Physics; Physiologic pulse; Position; Positioning Attribute; Program Announcement; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Pulse; Radiation, Laser; Research; Research Personnel; Research Proposals; Researchers; Resolution; Science of Medicine; Scientist; Semiconductors; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Software; Spectroscopy; Spectroscopy, Fluorescence; Spectrum Analyses; Spectrum Analysis; Speed; Speed (motion); Study, Interdisciplinary; Subcellular Process; Surface; Techniques; Time; Tissues; Training; Tube; Vision; acronyms; animal tissue; base; bioimaging; bioimaging/biomedical imaging; biological signal transduction; biomedical imaging; computer program/software; conference; data acquisition; design; designing; detector; digital; disease/disorder; gallium arsenide; heavy metal Pb; heavy metal lead; imaging; in vivo; instrument; instrumentation; macromolecule; multidisciplinary; nano crystal; nanocrystal; photomultiplier; programs; protein folding; prototype; public health medicine (field); quantum; single molecule; symposium","High-Resolution, High Speed, High-Throughput 3-Dimensional Detector for Biology",,6353,MI,Microscopic Imaging Study Section,,4,453645,
7766235,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB006882-04,,NIBIB:322570;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,MADISON,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KOROSEC, FRANK ;",8548208;,5R01EB006882,04/01/2007,01/31/2011,"Affect; Angiogram; Angiography; Arteries; Artifacts; Back; Blood Vessels; Characteristics; Contralateral; Data; Diagnostic; Doctor of Philosophy; Dorsum; Extremities; Goals; Hybrids; Image; Individual; Investigators; Limb structure; Limbs; Location; Lower Extremity; Lower Limb; Maps; Membrum inferius; Methods; Methods and Techniques; Methods, Other; Morphologic artifacts; Non-Trunk; Patients; Performance; Peripheral; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Ph.D.; PhD; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Radial; Relative; Relative (related person); Research Personnel; Researchers; Resolution; Series; Slice; Techniques; Time; Veins; base; cohort; experience; hemodynamics; imaging; improved; millimeter; peripheral blood vessel disorder; programs; simulation; vascular; volunteer",Time-Resolved Lower Extremity MR Angiography using HighlY Constrained Back PRojec,,6882,MEDI,Medical Imaging Study Section,,4,322570,
7763894,R01,EB,5,,02/01/2010,01/31/2011,PAR-03-045,5R01EB007205-04,,NIBIB:345858;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,DURHAM,UNITED STATES,BIOMEDICAL ENGINEERING,04,044387793,US,NC,27705,DUKE UNIVERSITY,"CHILKOTI, ASHUTOSH ;",2109494;,5R01EB007205,04/01/2007,01/31/2011,"Ablation; Affinity; Alanyl Aminopeptidase; Aminopeptidase M; Aminopeptidase N; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antigens, CD13; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Architecture; Astatine; Athymic Nude Mouse; Autoradiography; Autoradiography, Quantitative; Avidity; Binding; Binding (Molecular Function); Biodistribution; Biopolymers; Biosynthetic Proteins; Blood Vessels; Body Temperature; Body Weight decreased; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CD13; Caliber; Cancer Drug; Cancer Radiotherapy; Chemistry; Chemotherapeutic Agents, Neoplastic Disease; Colon; Diameter; Dose; Drug Exposure; Drugs; Elastin; Endothelium; Engineering; Engineering / Architecture; Engineerings; Extracellular Matrix, Integrins; Fever; Fluorescence; Gastrointestinal Tract, Pancreas; Generalized Growth; Genes; Genital System, Female, Ovary; Growth; Heating; Human; Human, General; Hyperthermia; Integrins; Investigators; Knowledge; Label; Laser Scanning Confocal Microscopy; Ligands; Man (Taxonomy); Man, Modern; Measurement; Medication; Membrane Alanyl Aminopeptidase; Methods; Mice, Athymic; Mice, Nude; Micelles; Molecular Interaction; Mortality; Mortality Vital Statistics; Nanostructures; Normal Tissue; Normal tissue morphology; Nude Mice; Organ; Outcome; Ovary; Pancreas; Pancreatic; Penetration; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase Transition; Primary Neoplasm; Primary Tumor; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pyrenes; Pyrexia; Quantitative Autoradiography; Radiation; Radiation therapy; Radioactive; Radioactive Isotopes; Radioautography; Radioisotopes; Radionuclides; Radiotherapeutics; Radiotherapy; Receptor Protein; Recombinant Proteins; Recombinants; Research; Research Personnel; Researchers; Resolution; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Scheme; Science of Chemistry; Solid Carcinoma; Solid Neoplasm; Solid Tumor; Spatial Distribution; Spectrophotometry; Structure; System; System, LOINC Axis 4; Temperature; Therapeutic; Therapeutic Studies; Therapy Research; Tissue Growth; Transition Temperature; Treatment Efficacy; Treatment Period; Tumor-Specific Treatment Agents; Weight Loss; Weight Reduction; alanine aminopeptidase; anti-cancer therapeutic; anticancer agent; anticancer drug; anticancer therapeutic; body weight loss; clinical hyperthermia; confocal scanning microscopy; copolymer; covalent bond; design; designing; drug/agent; febrile; febris; hyperthermia treatment; improved; in vivo; irradiation; light scattering; nano meter scale; nano meter sized; nano scale; nano-structures; nanometer scale; nanometer sized; nanoscale; ontogeny; overexpression; particle; polypeptide; programs; protein expression; ray (radiation); receptor; rod cell; self assembly; sub micron; submicron; therapeutic efficacy; therapeutic evaluation; therapeutically effective; treatment days; treatment duration; tumor; tumor xenograft; tumors in the brain; uptake; vascular; wt-loss",Thermally Triggered Multivalent Targeting of Tumors,,7205,ZRG1,Special Emphasis Panel,,4,345858,
7761282,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB007279-04,,NIBIB:245505;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,PHILADELPHIA,UNITED STATES,BIOCHEMISTRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"VINOGRADOV, SERGEI ;",6872756;,5R01EB007279,04/01/2007,01/31/2011,"Absorption; Animals; Biological; Boa; Brain; Cells; Charge; Choroid; Coloring Agents; Coupled; Coupling; Dendrimers; Dendritic Compounds; Dendrons; Development; Diffusion; Dorsal; Dyes; Electrons; Encephalon; Encephalons; Endocytosis; Energy Transfer; Environment; Eye; Eyeball; Funding; Grant; Image; In Vitro; Laboratories; Laser Scanning Microscopy; Letters; Liposomal; Liposomes; Maps; Medical; Medicine; Methods; Methods and Techniques; Methods, Other; Microscopic; Microscopy; Modeling; NIH; Nanoscale Science; Nanotechnology; National Institutes of Health; National Institutes of Health (U.S.); Negative Beta Particle; Negatrons; Nervous System, Brain; O element; O2 element; Ophthalmology; Optics; Oxidation-Reduction; Oxygen; Performance; Pharmacology; Physiologic pulse; Physiology; Pilot Projects; Preparation; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pulse; Redox; Retina; Retinal; Sampling; Scanning Microscopy, Laser; Science of Medicine; Solutions; Surface; System; System, LOINC Axis 4; Techniques; Technology; Testing; Time; Toxic effect; Toxicities; Triplet Multiple Birth; Triplets; United States National Institutes of Health; Work; absorption; aqueous; biological systems; chromophore; design; designing; imaging; in vivo; macromolecule; molecular imaging; nano particle; nano scale Science; nano sensing; nano sensors; nano tech; nano technology; nanoparticle; nanosensing; nanosensors; nanotech; oxidation reduction reaction; phosphorescence; pilot study; polyproline; prevent; preventing; programs; sensor; success; triplet state; tumor; two-photon; water solubility",Oxygen microscopy by two-photon excited phosphorescence,,7279,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,4,245505,
7747969,R01,EB,5,,02/01/2010,01/31/2011,,5R01EB007612-05,,NIBIB:437045;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CHAPEL HILL,UNITED STATES,CHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"ALLBRITTON, NANCY L;",1885746;,5R01EB007612,04/01/2007,01/31/2011,"Address; Area; Biomedical Research; Blood Coagulation Factor IV; Ca++ element; Calcium; Cell Adhesion; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Segregation; Cell Separation; Cell Separation Technology; Cell Shape; Cell Signaling; Cell Survival; Cell Viability; Cell-to-Cell Interaction; CellLine; Cells; Cellular Adhesion; Cellular biology; Characteristics; Chemicals; Cloning; Coagulation Factor IV; Collection; Computer Assisted; Computer Programs; Computer software; Criteria, Selection; Diabetes Mellitus; Electromagnetic, Laser; Enzymes; FP593; Factor IV; Generalized Growth; Growth; Health; Heterogeneity, Population; Image Cytometry; Individual; Instrumentation, Other; Intracellular Communication and Signaling; Lasers; Life; Maintenance; Maintenances; Mammalian Cell; Methods; Methods and Techniques; Methods, Other; Microscopy; Modification; Morphology; Oncogenesis; Oncogenic; Physiologic pulse; Population; Population Heterogeneity; Process; Property; Property, LOINC Axis 2; Protein translocation; Proteins; Pulse; RNA, Small Interfering; Radiation, Laser; Sample Size; Science; Selection Criteria; Series; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Software; Sorting - Cell Movement; Surface; Suspension substance; Suspensions; System; System, LOINC Axis 4; Techniques; Time; Tissue Growth; Transmembrane Protein Transport; Work; base; biological signal transduction; cell biology; cell sorting; cell transformation; computer aided; computer program/software; cultured cell line; design; designing; diabetes; diverse populations; drFP583; ds red protein; dsFP593; gene product; heterogeneous population; instrumentation; novel; ontogeny; red fluorescent protein; response; siRNA; sorting; suspension; transformed cells; tumorigenesis",Micropallet Arrays for Separation of Single Cells and Colonies,,7612,ISD,Instrumentation and Systems Development Study Section,,5,437045,
7783802,R01,EB,5,,02/01/2010,01/31/2011,PA-07-279,5R01EB009070-02,,NIBIB:395659;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,MENLO PARK,UNITED STATES,,14,009232752,US,CA,940253493,SRI INTERNATIONAL,"MAYER, DIRK ;",9344800;,5R01EB009070,04/01/2009,01/31/2013,"(S)-Lactate[{..}]NAD+ oxidoreductase; Absolute ethanol; Affect; Alanine; Alanine, L-Isomer; Alcohol Dehydrogenase (NAD+); Alcohol dehydrogenase; Alcohol, Ethyl; Alcohol-NAD+ Oxidoreductase; Algorithms; Analysis, Data; Animal Model; Animal Models and Related Studies; Animals; Artifacts; Bicarbonates; Bolus; Bolus Infusion; Cancer of Prostate; Cardiovascular Pathology; Cell Communication and Signaling; Cell Respiration; Cell Signaling; Cellular Respiration; Chemical Shift Imaging; Clinic; Clinical; Common Rat Strains; Data; Data Analyses; Development; Diagnosis; Disease; Disorder; EC 1.1.1.27; ETOH; Ethanol; Evaluation; Goals; Grain Alcohol; HCO3; Human; Human, General; Hydrogen Carbonates; Image; Imaging Procedures; Imaging Techniques; Injectable; Injection of therapeutic agent; Injections; Intermediary Metabolism; Intracellular Communication and Signaling; Kidney; Kinetic; Kinetics; L-Alanine; L-Lactate Dehydrogenase; L-Lactic Acid Dehydrogenase; LDH; Laboratories; Lactate Dehydrogenase; Liver; METBL; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Metabolic Diseases; Metabolic Disorder; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Methylcarbinol; Metric; Mice; Modeling; Monitor; Morphologic artifacts; Murine; Mus; NAD-Lactate Dehydrogenase; NADH; NMR Imaging; NMR Tomography; Nature; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Noise; Nuclear; Nuclear Magnetic Resonance; Nuclear Magnetic Resonance Imaging; Organ; Pathologic; Performance; Process; Production; Prostate CA; Prostate Cancer; Prostatic Cancer; Pyruvate; Pyruvate Metabolism; Pyruvate Metabolism Pathway; Pyruvates; Quantitative Evaluations; Rat; Rattus; Relaxation; Research; Resolution; Rodent; Rodent Model; Rodentia; Rodentias; SCHED; Schedule; Signal Transduction; Signal Transduction Systems; Signaling; Speed; Speed (motion); System; System, LOINC Axis 4; Technics, Imaging; Techniques; Technology; Temperature; Testing; Therapeutic Intervention; Thesaurismosis; Time; Toxic effect; Toxicities; Translations; Urinary System, Kidney; Work; Zeugmatography; aerobic metabolism; aerobic respiration; biological signal transduction; body system, hepatic; data acquisition; disease/disorder; imaging; in vivo; intervention therapy; lactic acid dehydrogenase; metabolism disorder; model organism; mouse model; nervous system disorder; neurological disease; new technology; organ system, hepatic; oxidative metabolism; public health relevance; renal; simulation; tool; tumor",Dynamic Metabolic Imaging of Hyperpolarized Substrates," Project Narrative Hyperpolarized magnetic resonance imaging with Dynamic Nuclear Polarization, that enhances signal-to-noise ratio on the order of the 10,000-fold, of injectable metabolically active substrates provides a unique method to assess metabolic processes and presents unprecedented opportunities for in vivo interrogation of normal and disease altered metabolism. It also poses new technical challenges as optimized data acquisition and analysis tools have yet to be developed. The goal of this technical development project is to implement and evaluate a robust set of sensitive techniques for the in vivo imaging of hyperpolarized substrates and their metabolic products.",9070,BMIT,Biomedical Imaging Technology Study Section,,2,395659,
7780063,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES003817-29,,NIEHS:449936;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,SALT LAKE CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"WINGE, DENNIS R.;",1885647;,5R01ES003817,05/01/1985,01/31/2014,"Abbreviations; Active Oxygen; Affect; Animals; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Brain; C element; Carbon; Cardiomyopathies; Cells; Cellular Stress; Chaperone; Complex; Copper; Cu element; Cytochrome Oxidase; Cytochrome Oxidase Deficiency; Cytochrome-c Oxidase (Complex IV); Cytochrome-c Oxidase Deficiency; Data; Defect; Disease; Disorder; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Encephalomyelitis, Subacute Necrotizing; Encephalomyelopathy, Subacute Necrotizing; Encephalon; Encephalons; Encephalopathy, Subacute Necrotizing; Eukaryota; Eukaryote; FLR; Failure (biologic function); Farnesyl Protein Transferase; Farnesyl Transferase; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Ferroprotoporphyrin; Fractionation, Polyacrylamide Gel; Future; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glean; Grant; Growth; H2O2; Heart; Heme; Heme b; Hepatic Failure; Hereditary; Human; Human Biology; Human Identifications; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Identifications, Human; Immune Precipitation; Immunoprecipitation; Impairment; Infant; Inherited; Inner mitochondrial membrane; Intermembrane Space of the Mitochondrion; Leigh Disease; Leigh Syndrome; Letters; Liver Failure; Man (Taxonomy); Man, Modern; Mediating; Metals; Mitochondrial Myopathies; Molecular Chaperones; Molecular Interaction; Mono-S; MonoS; Motivation; Mutate; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Nervous System, Brain; Nomenclature; Organism; Ortholog; Orthologous Gene; Outer Mitochondrial Membrane; Oxidation-Reduction; Oxidative Stress; Oxygen Radicals; Oxygenases; Pathology; Pathway interactions; Patients; Peroxides; Polyacrylamide Gel Electrophoresis; Predisposition gene; Printing; Pro-Oxidants; Process; Proteins; Protoheme; Protoheme IX; Reaction; Reactive Oxygen Species; Reading; Redox; Respiratory Chain; Role; S cerevisiae; Saccharomyces cerevisiae; Site; Source; Specificity; Susceptibility Gene; System; System, LOINC Axis 4; Tissue Growth; Tissues; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; cofactor; cytochrome c oxidase; disease/disorder; early childhood; environmental agent; eukaryotida; failure; farnesyltransferase; ferroheme; gene product; genome mutation; heme a; heme a3; insight; living system; mitochondrion intermembrane space; mutant; myocardium disorder; ontogeny; oxidation reduction reaction; pathway; predisposing gene; protein farnesyltransferase; public health relevance; social role; tool",Assembly of Redox Metal Centers in Cytochrome Oxidase," Assembly of the metal cofactor centers in cytochrome c oxidase is a conserved process in yeast and human cells. Mutations in cytochrome oxidase assembly factors that act in the synthesis or insertion of copper and heme redox cofactors leads to cytochrome oxidase deficiencies that can present as Leigh Syndrome, cardiomyopathy, encephalocardiomyopathy or hepatic failure. The most frequently mutated gene in Leigh Syndrome patients is SURF1 that encodes a protein that acts in heme a insertion in cytochrome oxidase.",3817,MSFA,Macromolecular Structure and Function A Study Section,,29,449936,
7812129,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES004344-17,,NIEHS:373592;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,NEW ORLEANS,UNITED STATES,PHARMACOLOGY,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"BACKES, WAYNE L;",1869352;,5R01ES004344,01/15/1988,01/31/2014,"Abbreviations; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Affect; Age; Aging; Aromatic Hydrocarbons; Behavior; Benzene, methyl-; Binding; Binding (Molecular Function); CP12; CPE1; CYP; CYP 2B4; CYP1A2; CYP1A2 gene; CYP2B4; CYP2E; CYP2E1; CYP2E1 gene; CYPE1; Cancers; Catalysis; Cell Respiration; Cells; Cellular Respiration; Charge; Chemicals; Coenzyme II; Complex; Coupling; Crowding; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P-450 Oxidase; Cytochrome P-450 Reductase; Cytochrome P450; Cytochrome P450 Reductase; Cytochromes; Dehydrogenases; EC 1.6.2.4; Effectiveness; Electron Transport; Electrons; Electrostatics; Endoplasmic Reticulum; Enzyme Interaction; Enzymes; Ergastoplasm; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferrihemoprotein P-450 Reductase; Ferrihemoprotein P450 Reductase; Ferroprotoporphyrin; Flavoproteins; Gasoline; Generations; Goals; Grant; Heme; Heme b; Heterogeneity; Hydrocarbons; Hydrocarbons, Aromatic; Hydroxylases; Hydroxylation; Individual; Intermediary Metabolism; Investigation; Laboratories; Lead; Lipids; Location; METBL; Malignant Neoplasms; Malignant Tumor; Mediating; Membrane; Metabolic Processes; Metabolism; Mixed Function Oxidases; Mixed Function Oxygenases; Models, Molecular; Molecular Interaction; Molecular Models; Monooxygenases; Mutagenesis, Site-Directed; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NADPH Cytochrome P-450 Oxidoreductase; NADPH Cytochrome P-450 Reductase; NADPH Cytochrome P450 Oxidoreductase; NADPH Cytochrome c Reductase; NADPH-Cytochrome P450 Reductase; NADPH-Ferrihemoprotein Reductase; NADPH-P450 Reductase; NADPH-Specific Cytochrome C Reductase; NADPH[{..}]ferrihemoprotein oxidoreductase; Negative Beta Particle; Negatrons; Nicotinamide-Adenine Dinucleotide Phosphate; Nucleic Acid Biochemistry, Molecular Modeling; O element; O2 element; Oxidoreductase; Oxygen; Oxygenases; P3-450; P450; P450(PA); P450-J; P450C2E; POR; Pb element; Phosphatides; Phospholipids; Process; Protein Subunits; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Protoheme; Protoheme IX; Reaction; Reductases; Research; Research Design; Reticulum; Role; Sea; Senescence; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Structure; Study Type; Surface; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Time; Toluene; Toxic effect; Toxicities; Triphosphopyridine Nucleotide; Xenobiotic Metabolism; Xenobiotics; aerobic metabolism; aerobic respiration; base; consumer product; cytochrome P-450 2B4; cytochrome P-450 CYP2B4 (rabbit); cytochrome P-450 LM(2); cytochrome P-450 LM2; cytochrome P450 2B4; cytochrome P450IIB4; design; designing; electron transfer; enzyme substrate; experiment; experimental research; experimental study; ferroheme; gene product; heavy metal Pb; heavy metal lead; malignancy; membrane structure; molecular modeling; neoplasm/cancer; oxidative metabolism; protein distribution; public health relevance; research study; senescent; social role; study design",Toxicological Significance of Alkylbenzene Metabolism," Project Narrative The purpose of this proposal is to examine the organization of the enzymes of the P450 system in membranes within the cell. How the P450s are organized will govern not only their effectiveness in removing foreign compounds from the body, but also their ability to form reactive compounds that can lead to toxicity, cancer, and aging.  ",4344,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,17,373592,
7762828,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES005775-18,,NIEHS:368271;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,NEW HAVEN,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"GLAZER, PETER M;",1875653;,5R01ES005775,09/30/1992,01/31/2013,"Animal Welfare; BRCA1; BRCA1 gene; Bibliography; Biochemical; Breast Cancer 1 Gene; Breast Cancer 1, Early Onset Gene; Breast Cancer Type 1 Susceptibility Gene; COCA1; COCA2; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Signaling; Cellular Stress; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Country; Critical Paths; Critical Pathways; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; Deoxyribonucleic Acid; Ecological impact; Electromagnetic Radiation, Ionizing; Environment; Environmental Impact; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equipment; Ethics Committees, Research; Event; FCC1; FCC2; Familial Breast and Ovarian Cancer Syndrome; Family; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genomics; HNPCC; HNPCC1; HNPCC2; Hereditary; Hereditary Breast Cancer 1; Hereditary Breast and Ovarian Cancer; Hereditary Breast and Ovarian Cancer Syndrome; Hypoxia; Hypoxic; IACUC; IRBs; Impact, Environmental; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Ionizing radiation; Link; MGC5172; MLH1; MLH1 gene; MMR; MSH2; MSH2 gene; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Methods and Techniques; Methods, Other; Mismatch Repair; Mutation; Names; Oxygen Deficiency; PSCP; Pathway interactions; Play; Post-Replication Mismatch Repair; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; RNF53; Radiation-Ionizing Total; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stress; Techniques; Testing; Therapeutic; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tumor Cell; Unscheduled DNA Synthesis; Vertebrate Animals; Vertebrates; Work; abstracting; anticancer therapy; biological adaptation to stress; biological signal transduction; brca 1 gene; cancer therapy; chromatin modification; cross-link; crosslink; expiration; gene repair; genome mutation; hMLH1; human subject; malignancy; neoplasm/cancer; neoplastic cell; pathway; programs; reaction; crisis; repair; repaired; response; social role; stress response; stress; reaction; transcription factor; tumor; vertebrata","Hypoxia, Genetic Instability and DNA Mismatch Repair",,5775,RTB,Radiation Therapeutics and Biology Study Section,,18,368271,
7762840,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES008801-10,,NIEHS:599436;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ALBUQUERQUE,UNITED STATES,,01,045911138,US,NM,87108,LOVELACE BIOMEDICAL & ENVIRONMENTAL RES,"BELINSKY, STEVEN A;",1884990;,5R01ES008801,02/05/1998,01/31/2011,"2(1H)-Pyrimidinone, 4-amino-; Adenocarcinoma; Adenoma, Malignant; Affect; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Cancer Causing Agents; Cancer of Lung; Carcinogen exposure; Carcinogens; Causality; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Transformation, Neoplastic; CellLine; Cells; Chromatin; Complementary DNA; CpG Islands; CpG-Rich Islands; Cytosine; DAP kinase; DNA Damage; DNA Injury; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA, Complementary; DNA-Methyltransferases; DNMT3a; Development; Dnmt; EC 2.1.1.113; Emerogenes; Epithelial; Epithelial Cells; Etiology; Event; Funding; Gene Down-Regulation; Gene Inactivation; Gene Silencing; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Transcription; Genomics; Goals; Grant; Growth; Heterochromatin; High Prevalence; Histone Code; Histones; Human; Human, General; Hypermethylation; Lung Adenocarcinoma; MGMT; MGMT gene; MNU; Malignant; Malignant - descriptor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Man (Taxonomy); Man, Modern; Methylation; Methylguanine-DNA Methyltransferase Gene; Methylnitrosourea; Modification; Modification Methylases; N-Methyl-N-nitrosourea; Neoplastic Cell Transformation; Nitrosomethylurea; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogens; Pathway interactions; Play; Process; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Methylation; Pulmonary Cancer; Pulmonary malignant Neoplasm; RNA Expression; Regulatory Protein; Repression; Role; Scanning; Site-Specific DNA-methyltransferase; Smoker; Smoking Status; Targetings, Gene; Telomerase; Time; Tissue Growth; Tobacco-Associated Carcinogen; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Transfection; Tumor Suppressing Genes; Tumor Suppressor Genes; Urea, N-methyl-N-nitroso-; base; cDNA; cultured cell line; death-associated protein kinase; disease causation; disease etiology; disease/disorder etiology; disorder etiology; gene discovery; gene repression; genetic promoter element; genetic regulatory protein; hDNA methyltransferase 3a; histone modification; knock-down; lung cancer; neoplastic transformation; novel; oncosuppressor gene; ontogeny; pathway; regulatory gene product; social role; transcription factor",Tumor Suppressor Gene Methylation in Lung Adenocarcinoma,,8801,CE,Cancer Etiology Study Section,,10,599436,
7751925,R01,ES,5,,01/01/2010,12/31/2010,,5R01ES012708-05,,NIEHS:349036;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ROCHESTER,UNITED STATES,GENETICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"NOBLE, MARK D;",2083946;,5R01ES012708,02/01/2006,12/31/2010,"Active Oxygen; Address; Animals; Biochemical; Biological; Blood; Blood Circulation; Bloodstream; Brain; Cancers; Cell Death; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell division; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Migration; Cellular Physiology; Cellular Process; Chemical Structure; Chemistry; Circulation; Clinical; Development; Differentiating Agents; Differentiation Agents; Differentiation Inducer; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Formulations; Employee Strikes; Encephalon; Encephalons; Environment; Exposure to; Follow-Up Studies; Followup Studies; Formulation; Formulations, Drug; Genotoxins; Goals; Human; Human, General; Individual; Investigation; Knowledge; Laboratories; Ligase; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mercury Compounds; Methyl Mercury Compounds; Methylmercury Compounds; Mother Cells; Motility; Motility, Cellular; Mutagens; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurites; Neurocyte; Neurons; Oxidation-Reduction; Oxidative Stress; Oxygen Radicals; Pathway interactions; Physiologic; Physiological; Population; Principal Investigator; Pro-Oxidants; Probability; Progenitor Cells; Programs (PT); Programs [Publication Type]; Reaction; Reactive Oxygen Species; Receptor Protein; Redox; Research; Reticuloendothelial System, Blood; Role; Science of Chemistry; Stem cells; Strikes; Strikes, Employee; Subcellular Process; Sum; Synthetases; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicant exposure; Toxicities; Toxicology; Work; adult animal; cell growth; cell motility; chemotherapeutic agent; clinical relevance; clinically relevant; genotoxic agent; in vivo; injury response; malignancy; mature animal; methylmercury; necrocytosis; neoplasm/cancer; neural precursor cell; neuronal; neurotoxicology; oxidation reduction reaction; pathway; precursor cell; premature; programs; receptor; response to injury; rho; social role; stressor; theories; toxic exposure; toxicant; toxicant interaction",Low-level toxicant perturbation of neural cell function,,12708,ZRG1,Special Emphasis Panel,,5,349036,
7761693,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES013686-04,,NIEHS:253998;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ITHACA,UNITED STATES,ZOOLOGY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"SODERLUND, DAVID M;",2087912;,5R01ES013686,04/01/2007,01/31/2012,"Action Potentials; Acute; Affect; Agriculture; Amino Acid Sequence; Animals; Binding; Binding (Molecular Function); Body Tissues; Cells; Common Rat Strains; Development; Drug or chemical Tissue Distribution; Electrodes; Exhibits; Family; Frog; Funding; Human; Human, General; Insect Vectors; Insecta; Insecticides; Insects; Intoxication; Invertebrates, Insects; Investigators; Ion Channels, Sodium; Isoforms; Kinetic; Kinetics; Macromolecular Structure; Mammalian Cell; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Mediating; Modeling; Modification; Molecular; Molecular Interaction; Molecular Structure; Multigene Family; Muscle, Cardiac; Muscle, Heart; Mutagenesis, Site-Directed; Mutate; Myocardium; NRVS-SYS; Na element; Nature; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Oocytes; Ovocytes; Permeability; Pharmacology; Platanna; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Structure, Primary; Public Health; Rana; Rana (genus); Rat; Rattus; Receptor Protein; Regulation; Research; Research Personnel; Researchers; Resistance; Role; Severities; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium; Sodium Channel; Targeted DNA Modification; Targeted Modification; Testing; Tissue Distribution; Tissues; Toxic effect; Toxicities; V (voltage); Xenopus laevis; Xenopus oocyte; agricultural; base; cardiac muscle; heart muscle; human disease; insight; member; neuron toxicity; neuronal; neuronal toxicity; neurotoxic; neurotoxicity; patch clamp; programs; protein sequence; public health medicine (field); pyrethroid; receptor; resistant; skeletal; social role; voltage; voltage clamp",Molecular Determinants of Pyrethroid Neurotoxicity,,13686,NAL,Neurotoxicology and Alcohol Study Section,,4,253998,
7772341,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES013784-05,,NIEHS:314747;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,MISSOULA,UNITED STATES,OTHER HEALTH PROFESSIONS,00,010379790,US,MT,598124104,UNIVERSITY OF MONTANA,"SHEPHERD, DAVID M;",8180731;,5R01ES013784,02/01/2006,01/31/2011,"2,3,7,8-Tetrachlorodibenzo-p-dioxin; AHR; APC; ATGN; Address; Adoptive Transfer; Affect; Ahr protein, mouse; Allergy; Animals, Laboratory; Antigen-Presenting Cells; Antigens; Apoptosis; Apoptosis Antigen Ligand 1; Apoptosis Pathway; Aromatic Hydrocarbons; Aryl Hydrocarbon Receptor; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); Body Tissues; CD178 Antigen; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD95 Ligand; CD95 antigen ligand; Cell Communication; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Interaction; Cell Mediated Immunology; Cell Process; Cell Signaling; Cell physiology; Cell-Mediated Immunity; Cell-to-Cell Interaction; Cells, CD4; Cellular Function; Cellular Immunity; Cellular Physiology; Cellular Process; Cessation of life; Chronic; Closure by Ligation; Communicable Diseases; Data; Death; Defect; Dendritic Cells; Development; Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-; Dioxin Compound; Dioxins; Disease; Disorder; Dose; Dysfunction; Edodekin Alfa; Environmental Pollution; Exposure to; Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Functional disorder; Gene Targeting; Generations; Goals; Health; Human; Human, General; Hydrocarbons, Aromatic; Hypersensitivity; IFN-gamma-Inducing Factor; IGIF; IL-1 Gamma; IL-12; IL-18; IL-1g; IL12; IL18 Protein; IL1F4; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immune response; Immune system; Immunity; Immunity, Cellular; Immunologic Accessory Cells; Immunologic Diseases; Immunological Diseases; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammatory; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin-1 Gamma; Interleukin-12; Interleukin-18; Interleukin-18 Precursor; Intracellular Communication and Signaling; Knowledge; LEF Transcription Factor; Laboratories; Laboratory Animals; Ligands; Ligation; Lymph node proper; Lymphoid Enhancer Factor; MGC12320; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Molecular; Molecular Interaction; Monocytes / Macrophages / APC; Murine; Mus; NKSF; Natural Killer Cell Stimulatory Factor; Natural immunosuppression; Nuclear Translocator; Pathway interactions; Physiopathology; Play; Predisposition; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Receptor Activation; Receptor Protein; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Research; Response Elements; Reticuloendothelial System, Lymph Node; Role; Signal Transduction; Signal Transduction Systems; Signaling; Subcellular Process; Susceptibility; T Cell Factor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TCDD; TCDD Receptors; TCF Transcription Factor; Targetings, Gene; Testing; Tetrachlorodibenzodioxin; Thymus-Dependent Lymphocytes; Tissues; Toxic effect; Toxicities; Transplantation; Tumor Necrosis Factor Ligand Superfamily Member 6; Veiled Cells; Work; Xenobiotics; accessory cell; ahr ligand; aryl hydrocarbon receptor ligand; aryl-hydrocarbon receptor, mouse; base; biological signal transduction; body system, allergic/immunologic; cell mediated immune response; cellular targeting; dioxin receptor, nuclear translocator; disease/disorder; environmental chemical; environmental contaminant; environmental contamination; genetic promoter element; helper T cell; host response; immunogen; immunoresponse; immunosuppression; immunotoxicity; innovate; innovation; innovative; lymph gland; lymph nodes; mouse Ahr protein; necrocytosis; new therapeutics; next generation therapeutics; novel therapeutic intervention; novel therapeutics; organ system, allergic/immunologic; pathophysiology; pathway; premature; receptor; response; self recognition (immune); social role; thymus derived lymphocyte; toxic reaction in immunology; transplant",Consequences of AhR Activation in Dendritic Cells,,13784,ZRG1,Special Emphasis Panel,,5,314747,
7763800,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES014370-05,,NIEHS:531062;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BOSTON,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,08,149617367,US,MA,02115,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),"HAUSER, RUSS B;",1875987;,5R01ES014370,04/13/2006,01/31/2011,"(17Beta)-17-hydroxyandrost-4-en-3-one; 0-11 years old; 17-beta-Hydroxy-4-Androsten-3-one; 21+ years old; 2nd World War; 3,5,3',5'-Tetraiodothyronine; 9 year old; Active Follow-up; Adult; Age; Age of Onset; Air; Androst-4-en-17beta-ol-3-one; Animals, Laboratory; Applications Grants; Aromatic Hydrocarbons; Articulation; BMI percentile; BMI z-score; Behavioral; Biochemical; Blood; Blood Sample; Blood Serum; Blood specimen; Body Composition; Body fat; Body mass index; Bovine Species; Breast Milk; Cattle; Causality; Chemical Warfare Agents; Chemicals; Chemotherapy-Hormones/Steroids; Child; Child Youth; Childhood; Children (0-21); Chlorine; Cl element; Clinical; Cohort Studies; Communities; Complex; Concurrent Studies; Delta4-androsten-17beta-ol-3-one; Development; Diet; Dioxin Compound; Dioxins; Endocrine Disrupter; Endocrine Disrupting Chemicals; Endocrine Disruptors; Endocrine Gland Secretion; Endocrine disrupting agent; Entire hair of pubis; Environment; Environmental Pollution; Etiology; Exposure to; FSH; Family; Fat Body; Fecundability; Fecundity; Fertility; Follicle Stimulating Hormone; Follitropin; Funding; General Population; General Public; Generalized Growth; Genital; Genital system; Gonadal Steroid Hormones; Gonadotropins; Grant Proposals; Grants, Applications; Growth; Growth and Development; Growth and Development function; Health; Hormonal; Hormones; Human; Human Milk; Human Mother's Milk; Human, Adult; Human, Child; Human, General; Hydrocarbons, Aromatic; IGF-1; IGF-Binding Protein 3; IGF-I; IGF-I-SmC; IGF1; IGFBP-3; IGFBP3; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intermediary Metabolism; Interstitial Cell Stimulating Hormone; Interstitial Cell-Stimulating Hormone; Investigators; Joints; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; LTH; Laboratory Animals; Lactogenic Hormone, Pituitary; Leptin; Leuteinizing Hormone; Levothyroxine; Longitudinal Studies; Luteinizing Hormone; Lutropin; METBL; Mammary Gland Milk; Mammotropic Hormone, Pituitary; Mammotropin; Man (Taxonomy); Man, Modern; Measurement; Measures; Mental disorders; Mental health disorders; Metabolic Processes; Metabolism; Milk, Human; Mono-S; MonoS; Mothers; Muellerian inhibiting hormone; Mullerian-inhibiting factor; NIH RFA; National Institute of Environmental Health Sciences; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Overnutrition; PCBs; PRL; PRL (Prolactin); Physiologic; Physiological; Pituitary Lutenizing Hormone; Polychlorinated Biphenyls; Polychlorobiphenyl Compounds; Population; Population Study; Prolactin; Prospective Studies; Psychiatric Disease; Psychiatric Disorder; Puberty; Pubic Hair; Public Health; Quetelet index; Recombinant Luteinizing Hormone; Recombinant TSH; Recombinant Thyroid-Stimulating Hormone; Recruitment Activity; Reporting; Request for Applications; Research Personnel; Researchers; Reticuloendothelial System, Blood; Risk; Risk Factors; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Second World War; Serum; Sex Hormones; Sex Maturation; Sex Steroid Hormones; Sexual Maturation; Soil; Somatomedin C; Source; Special Population; Staging; Steroid Compound; Steroids; T4 Thyroid Hormone; Testosterone; Testosterone Sulfate; Therapeutic Hormone; Therapeutic LH; Therapeutic Levothyroxine; Therapeutic Testosterone; Thyreotropin; Thyroid Stimulating Hormone; Thyroid-Stimulating Hormone; Thyrotropin; Thyroxine; Time; Tissue Growth; Toxin; Trans-Testosterone; Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-; Unspecified Mental Disorder; Vulnerable Populations; Weight; Weight Gain; Weight Increase; World War II; World War, 1939-1945; adiposity; adult human (21+); anti-mullerian factor; anti-mullerian hormone; antimullerian hormone; body weight gain; body weight increase; bovid; bovine; boys; chemical warfare substances; children; chlorine gas; cohort; corpulence; corpulency; corpulentia; cow; dibenzo(1,4)dioxin; dibenzo(b,e)(1,4)dioxin; dibenzo-p-dioxin; dibenzofuran; disease causation; disease etiology; disease/disorder etiology; disorder etiology; early onset; endocrine disrupting compound; environmental chemical; environmental contaminant; environmental contamination; exposed human population; follow-up; girls; gonadal steroids; high risk; human exposure; human puberty; hypothalamic pituitary gonadal axis; inhibin B; long-term study; luteotropic hormone; luteotropin; male; mental illness; mullerian inhibiting substance; mullerian regression factor; mullerian-inhibiting hormone; mullerian-inhibitory substance; named group; nine year old; ob/ob mouse; obese; obese people; obese person; obese population; obesity risk; ontogeny; pediatric; peptide hormone; polychlorinated dibenzofurans; polychlorobiphenyl; prospective; psychological disorder; public health medicine (field); recruit; reproductive; reproductive axis; sex; sex steroid; thyroxin; trend; urogenital system (genital part); wasting; wt gain; youngster",Dioxins and Male Pubertal Growth and Development,,14370,ZRG1,Special Emphasis Panel,,5,531062,
7761718,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES014826-03,,NIEHS:285678;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,GRAND FORKS,UNITED STATES,PHARMACOLOGY,00,102280781,US,ND,58202,UNIVERSITY OF NORTH DAKOTA,"GHRIBI, OTHMAN ;",7142086;,5R01ES014826,03/01/2008,01/31/2013,"1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-; 27-hydroxycholesterol; 5-cholestene-3 beta,27-diol; Active Oxygen; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimer's disease risk; Alzheimers Dementia; Alzheimers disease; Amyloid; Amyloid Substance; Amyloid deposition; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Biological Models; Blood; Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Death, Programmed; Characteristics; Chelating Agents; Chelators; Cholest-5-en-3-ol (3beta)-; Cholesterol; Complex; Complexons; DIF; DNA Alteration; DNA mutation; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diet; Disease; Disorder; Dysfunction; Encephalon; Encephalons; Eptastatin; Exhibits; Fe element; Functional disorder; GADD45; Gene Alteration; Gene Mutation; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Health; Hemato-Encephalic Barrier; Hereditary; Hypercholesteremia; Inherited; Iron; Iron Chelation; Lead; Link; Mammals, Rabbits; Model System; Models, Biologic; Mutation; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Organ System, Cardiovascular; Oryctolagus cuniculus; Outcome; Oxidative Stress; Oxidative Stress Induction; Oxygen Radicals; Pathogenesis; Pathology; Pb element; Physiopathology; Pravastatin; Prevention; Primary Senile Degenerative Dementia; Pro-Oxidants; Rabbit, Domestic; Rabbits; Reactive Oxygen Species; Reticuloendothelial System, Blood; Risk Factors; Role; Sequence Alteration; Simvastatin; Synvinolin; TNF; TNF A; TNF gene; TNFSF2; Testing; Therapeutic; Therapeutic Intervention; Trace metal; Tumor Necrosis Factor Gene; Vascular, Heart; abstracting; base; biological adaptation to stress; cellular development; cholest-5-ene-3 beta,27-diol; circulatory system; cytokine; dementia of the Alzheimer type; design; designing; disease/disorder; effective therapy; endoplasmic reticulum stress; familial Alzheimer disease; familial Alzheimer disease (FAD); feeding; genome mutation; heavy metal Pb; heavy metal lead; hypercholesterolemia; in vivo Model; intervention therapy; iron metabolism; model organism; neurodegenerative illness; pathophysiology; prevent; preventing; primary degenerative dementia; reaction; crisis; senile dementia of the Alzheimer type; social role; stress response; stress; reaction",Cholesterol induces oxidative stress and triggers iron and A? accumulation,,14826,ZRG1,Special Emphasis Panel,,3,285678,
7766917,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES015359-04,,NIEHS:1005627;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,DAVIS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"HERTZ-PICCIOTTO, IRVA ;",1887451;,5R01ES015359,02/08/2007,01/31/2012,"0-11 years old; 0-6 weeks old; 5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitile; Address; Affect; Assisted Reproduction Technology; Assisted Reproductive Technology; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavioral; Biochemical Markers; Blood; Blood Sample; Blood specimen; Body Burden; Characteristics; Charge; Child; Child Development Disorders, Specific; Child Youth; Childhood; Children (0-21); Clinic; Communication; Conceptions; Data Collection; Dental Amalgam; Dental materials and fillings, amalgams; Development; Developmental Delay; Developmental Delay Disorders; Diet; Disease; Disorder; Drugs; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Factor; Environmental Health; Environmental Health Science; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Exposure to; Fever; Fire Retardants; Flame Retardants; Funding; GST1; GSTM1; GSTM1 gene; General Population; General Public; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Risk; Genetic Susceptibility; Gestation; Glutathione S-Transferase M1 Gene; Goals; Home; Home environment; Human, Child; Hyperthermia; IMPHENO; Immune; Immune system; Immunologic, Immunochemical; Immunologics; Immunophenotyping; Infant, Newborn; Infection; Inflammatory Response; Inherited Predisposition; Inherited Susceptibility; Institutes; Intermediary Metabolism; Interview; Investigation; Investigators; Kanner's Syndrome; Language; Life; Low Prevalence; METBL; Markers, Biochemical; Maternal Exposure; Measures; Medical; Medical Records; Medication; Metabolic Processes; Metabolism; Metal exposure; Metals; Mind; Nasal; National Institute of Environmental Health Sciences; Neural Development; Neurodevelopmental Disorder; Neurological Development Disorder; Newborn Infant; Newborns; Nose; Nose, Nasal Passages; Parents; Participant; Pathogenesis; Pattern; Perinatal; Pesticides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Play; Polymorphism (Genetics); Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Prevalence; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Pyrethrins; Pyrexia; R01 Mechanism; R01 Program; RPG; Regulation; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Respiratory System, Nose, Nasal Passages; Reticuloendothelial System, Blood; Risk; Risk Factors; Role; SUBGP; Sample Size; Self Care; Social Interaction; Specificity; Spottings; Subgroup; Subtyping, Immunologic; Subtypings, Immunologic; Technology, Assisted Reproductive; Time; Vaccines; Work; Writing; Xenobiotic Metabolism; Xenobiotics; abstracting; base; body system, allergic/immunologic; case control; children; cognitive function; commercial application; cost; developmental disease/disorder; developmental disorder; diphenyl ether; disease/disorder; drug metabolism; drug/agent; early childhood; early onset; enroll; environment effect on gene; environmental risk; exposure to metal; falls; febrile; febris; fipronil; gene environment interaction; gene interaction; genetic etiology; genetic mechanism of disease; genetic profiling; genetic vulnerability; immunophenotype; interest; metal metabolism; neurodevelopment; newborn human (0-6 weeks); organ system, allergic/immunologic; pediatric; personal care; pesticide exposure; phenyl ether; polymorphism; population based; prenatal; programs; public health medicine (field); skills; social role; unborn; urinary; youngster",The Charge Study: Childhood Autism Risks from Genetics and the Environment,,15359,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,4,1005627,
7761706,R01,ES,5,,02/01/2010,01/31/2011,,5R01ES015550-04,,NIEHS:282038;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BURLINGTON,UNITED STATES,ANATOMY/CELL BIOLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"RAND, MATTHEW D;",1980790;,5R01ES015550,04/20/2007,01/31/2012,"0-11 years old; Alleles; Allelomorphs; Assay; Astrocytosis; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biological Assay; Blood; Brain; Candidate Disease Gene; Candidate Gene; Causality; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell/Tissue, Immunohistochemistry; Chemistry, Biological; Child; Child Youth; Children (0-21); Cognitive deficits; Consumption; Cysteine; Data; Defense Mechanisms; Dose; Drosophila; Drosophila genus; Embryo; Embryonic; Embryonic Nervous System; Encephalon; Encephalons; Environmental Toxin; Etiology; Event; Exposure to; Expression Profiling; Expression Signature; Female of child bearing age; Female of childbearing age; Fetal Development; Fetal development of the mammalian embryo or fetus; Fishes; Flies; Fruit Fly, Drosophila; Genetics-Mutagenesis; Glia; Glial Cells; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Half-Cystine; Health; Hg element; Human; Human, Child; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Individual; Intoxication; Intracellular Communication and Signaling; Investigators; Kolliker's reticulum; L-Cysteine; Man (Taxonomy); Man, Modern; Mercaptans; Mercapto Compounds; Mercury; Metallopeptidases; Metalloproteases; Metalloproteinases; Methyl Mercury Compounds; Methylmercury Compounds; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Mothers; Mutagenesis; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Development; Neural Growth; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Organ System; Neuronal Growth; Neurons; Neurotoxins; Non-neuronal cell; Pathway interactions; Poisoning; Predisposition; Proteins; Receptor Signaling; Regulation; Research Personnel; Researchers; Resistance; Reticuloendothelial System, Blood; Risk; Role; Sea-Food; Seafood; Selection (Genetics); Siblings; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sulfhydryl Compounds; Susceptibility; Testing; Thiols; Toxic Environmental Agents; Toxic Environmental Substances; Toxic effect; Toxicities; Transcript; Up-Regulation; Up-Regulation (Physiology); Upregulation; base; biological signal transduction; biomarker; cell determination; children; disease causation; disease etiology; disease/disorder etiology; disorder etiology; environmental toxicant; experiment; experimental research; experimental study; exposed human population; fetal; fly; fruit fly; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; human exposure; in vivo; metalloproteinase (general); methylmercury; migration; molecuar profile; molecular signature; mutant; nerve cement; nervous system development; neural; neuroblast; neurodevelopment; neurogenesis; neuronal; neurotoxicant; notch; notch protein; notch receptors; pathway; poisoned; prenatal; psychological defense mechanism; relating to nervous system; research study; resistant; resistant strain; social role; substantia alba; sulfhydryl group; ubiquitin ligase; unborn; white matter; women of child bearing age; women of childbearing age; youngster",Mechanisms of methylmercury toxicity in neural development,,15550,NAL,Neurotoxicology and Alcohol Study Section,,4,282038,
7784473,R01,ES,5,,01/27/2010,11/30/2010,PA-07-070,5R01ES015579-02,,NIEHS:549166;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,NEW YORK,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"RAUH, VIRGINIA A;",2018257;,5R01ES015579,03/11/2009,11/30/2013,"0-11 years old; 10 year old; 3 year old; 9 year old; AD/HD; ADHD; Adverse effects; Affect; Agriculture; Air Pollutants; Ammon Horn; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animals; Area; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavioral; Birth Weight; Blood, Cord; Bp50; Brain; Brain Chemistry; Brain region; CD40; CDW40; Chemicals; Child; Child Development; Child Development Disorders, Specific; Child Youth; Children (0-21); Chlorpyrifos; Clinical; Cognition; Cognitive; Cohort Studies; Concurrent Studies; Cornu Ammonis; Depression; Development; Developmental Delay; Developmental Delay Disorders; Diagnosis; Diazinon; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Dimpylate; Documentation; Dose; Encephalon; Encephalons; Environmental Health; Environmental Health Science; Exposure to; Fetal Growth; Fiber; Growth, Fetal; Head; Health; Hippocampus; Hippocampus (Brain); Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Image; Infant and Child Development; Intermediary Metabolism; Lateral; Literature; Locomotor Activity; Longitudinal Studies; METBL; MGC9013; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Memory; Mental Depression; Metabolic Processes; Metabolism; Modeling; Motor; Motor Activity; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; NMR Imaging; NMR Tomography; National Institute of Environmental Health Sciences; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Development; Neurobiology; Neurocyte; Neurons; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Organophosphates; Parietal; Pattern; Performance; Pesticides; Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester; Phosphorothioic acid, O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester; Problem behavior; Regression Analyses; Regression Analysis; Regression Diagnostics; Relative; Relative (related person); SUBGP; Safety; Science of Anatomy; Sensorimotor functions; Sensory; Severities; Statistical Regression; Structure; Subgroup; Symptoms; TNFRSF5; TNFRSF5 gene; Temporal Lobe; Translational Research; Translational Research Enterprise; Translational Science; Treatment Side Effects; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Umbilical Cord Blood; United States; Work; Zeugmatography; agricultural; anatomy; association cortex; attention deficit hyperactive disorder; base; behavioral problem; biomarker; brain size; brain volume; children; cognitive function; cohort; diffusion tensor imaging; early childhood; fetal cord blood; hippocampal; imaging; inattention; inattentiveness; indexing; inner city; intrauterine growth; long-term study; model organism; neural; neurobehavioral; neurobiological; neurodevelopment; neuroimaging; neuronal; neuropsychological; nine year old; organophosphate exposure; p50; postnatal; prenatal; prenatal exposure; prenatally exposed; prospective; psychologic; psychological; public health relevance; relating to nervous system; respiratory; response; side effect; substantia alba; temporal cortex; temporal lobe/cortex; ten year old; therapy adverse effect; three year old; toxic organophosphate insecticide exposure; translation research enterprise; treatment adverse effect; unborn; white matter; youngster",Assess the Effects of Pre- and Postnatal exposure to the organophosphorus," Project Narrative This application is for a 5-year study to assess the effects of exposure to the organophosphorus pesticides, chlorpyrifos and diazinon, on neurobehavioral functioning in a cohort of inner-city children (n=400) who have reached 8-9 years of age. This work shares a cohort with a longitudinal study of ambient air pollutant effects on child development, from the prenatal period to 9 years of age, being conducted by the Columbia Center for Children's Environmental Health. The project has access to biomarkers of exposure, includes neuroimaging assessments on a subset of 60 children, and has potential for further informing regulatory safety standards for OP use in the United States.",15579,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,2,549166,
7761262,R01,ES,5,,02/01/2010,01/31/2011,ES-06-006,5R01ES016197-03,,NIEHS:295993;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,CHARLESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"MAY, HAROLD D;",7702332;,5R01ES016197,02/15/2008,01/31/2011,"Adipose tissue; Aerobic; Aerobic Bacteria; Affect; Animals; Assay; Attenuated; Back; Bacteria; Bacteria, Aerobic; Bioassay; Biodegradation; Biologic Assays; Biological Assay; Bioremediations; CO2; Cancer Induction; Carbon Dioxide; Carbonic Anhydride; Cell Respiration; Cellular Respiration; Chlorine; Chlorobenzenes; Cl element; Communities; Dermal; Detoxification Process; Development; Dioxin Compound; Dioxins; Disease; Disorder; Dorsum; Drug Metabolic Detoxication; Electrolyses; Electrolysis; Endocrine; Environment; Exposure to; Fatty Tissue; Fishes; Food Chain; General Population; General Public; Generations; H element; Health; Hepatotoxic effect; Hepatotoxicity; Human; Human, General; Hydrogen; Hydrogen Oxide; Hydrolysis; In Situ; Intermediary Metabolism; Lead; Liver Toxicity; METBL; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Marines; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Methods; Microorganisms, General; Molecular; Molecular Weight; Monitor; O element; O2 element; Oxygen; PCBs; Pathway interactions; Pb element; Polychlorinated Biphenyls; Polychlorobiphenyl Compounds; Process; Respiration; Risk; Site; System; System, LOINC Axis 4; Testing; Toxic effect; Toxic effect on liver cells; Toxicities; Water; adipose; aerobe; aerobic metabolism; aerobic respiration; carcinogenesis; chlorine gas; chlorobenzene; dechlorination; dehalogenation; detoxification; disease/disorder; electron donor; heavy metal Pb; heavy metal lead; hepatoxicity; immunotoxicity; innovate; innovation; innovative; member; microbial; microbial community; microorganism; microorganism mass culture; mineralization; monochlorobenzene; new approaches; novel approaches; novel strategies; novel strategy; oxidative metabolism; pathway; pollutant; polychlorobiphenyl; respiratory mechanism; scale up; toxic reaction in immunology; white adipose tissue; yellow adipose tissue",Integrating microbial biostimulation and electrolytic aeration to degrade POPs,,16197,ZES1,Special Emphasis Panel,,3,295993,
7761263,R01,ES,5,,02/01/2010,01/31/2011,ES-06-006,5R01ES016205-03,,NIEHS:244477;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,BOSTON,UNITED STATES,ENGINEERING (ALL TYPES),08,001423631,US,MA,02115,NORTHEASTERN UNIVERSITY,"SHEAHAN, THOMAS CLAIR;",8865473;,5R01ES016205,04/09/2008,01/31/2011,"Accounting; Address; Adsorption; Affect; Amendment; Area; Binding; Binding (Molecular Function); Bioavailability; Biologic Availability; Biological; Biological Availability; Black, Carbon; Carbon Black; Chemicals; Chemistry; Chlordan; Chlordane; Communities; Computers; Containment; Development; Devices; Diffusion; Ecological impact; Effectiveness; Engineering; Engineerings; Environment; Environmental Impact; Fe element; Food Webs; Fresh Water; Freshwater; Future; Health; Heavy Metals; Human; Human, General; Hydrocarbons; Hydrogen Oxide; Immigrations; Impact, Environmental; In-Migration; Ingestion; Investigators; Iron; Life; Liquid substance; Man (Taxonomy); Man, Modern; Mechanics; Metals; Metals, Heavy; Modeling; Molecular Interaction; Organism; Outcome; PCBs; Pathway interactions; Performance; Phase; Physical Phenomena or Properties; Physiologic Availability; Polychlorinated Biphenyls; Polychlorobiphenyl Compounds; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Public Health; Reaction; Recovery; Research; Research Personnel; Researchers; Risk; Rivers; Sampling; Science of Chemistry; Services; Sodium Chloride; Sodium chloride (NaCl); Soil; Surface; System; System, LOINC Axis 4; Testing; Thick; Thickness; Water; Webs, Food; Work; bioaccumulation; bioavailability of drug; contaminant transport; design; designing; experiment; experimental research; experimental study; exposed human population; fluid; fluid flow; gamma-Chlordane; human exposure; innovate; innovation; innovative; liquid; living system; member; pathway; physical process; polychlorobiphenyl; pressure; programs; public health medicine (field); remediation; research study; salt; superfund site; tool",A reactive mat to remediate contaminated sediments and reduce health risks,,16205,ZES1,Special Emphasis Panel,,3,244477,
7763214,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES016336-03,,NIEHS:342940;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,MISSOULA,UNITED STATES,OTHER HEALTH PROFESSIONS,00,010379790,US,MT,598124104,UNIVERSITY OF MONTANA,"NOONAN, CURTIS WILLIAM;WARD, ANTHONY JOHN (contact);",8324652;8854991 (contact);,5R01ES016336,05/01/2008,01/31/2013,"0-11 years old; 1,6-anhydro-beta-D-glucopyranose; 1,6-anhydro-beta-glucopyranose; Address; Air; Air Pollution, Indoor; Area; Arm; Asthma; Biomass; Bronchial Asthma; Burn injury; Burns; Chemicals; Child; Child Youth; Children (0-21); Communities; Data; Developing Countries; Developing Nations; Devices; Drugs; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Exhalation; Exhaling; Expiration, Respiratory; FEV1; FEV1%VC; FEVt; Forced Expiratory Volume; Forced Expiratory Volume 1 Test; Forced Expiratory Volume in 1 Second; Forced Vital Capacity, Timed; Forced expiratory volume function; Frequencies (time pattern); Frequency; Health; Health Care Utilization; Heating; Home; Home environment; Household; Human, Child; Idaho; Indoor Air Pollution; Indoor Air Quality; Intervention; Intervention Strategies; Intervention Trial; Knowledge; Less-Developed Countries; Less-Developed Nations; Life; Link; Measures; Medication; Mononitrogen Monoxide; Montana; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Outcome; Outcome Measure; PBO; PFT/FEV1; Particulate; Particulate Matter; Peak Expiratory Flow; Pharmaceutic Preparations; Pharmaceutical Preparations; Placebo Control; Placebos; Population; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; QOL; Quality of life; Randomized; Randomized Controlled Trials; Rural; Rural Community; Sham Treatment; Smoke; Source; Symptoms; Testing; Third-World Countries; Third-World Nations; Under-Developed Countries; Under-Developed Nations; Upper arm; Urinary System, Urine; Urine; Vital Capacity, Timed; Wood; Wood material; abietic acid; air filtration; american indian reservation; biomarker; children; clinical relevance; clinical significance; clinically relevant; clinically significant; cooking; drug/agent; endothelial cell derived relaxing factor; health care service utilization; health services utilization; healthcare service utilization; healthcare utilization; improved; indian reservation; interventional strategy; levoglucosan; nation reservation; native american reservation; post intervention; public health medicine (field); randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; reservation community; respiratory; sham therapy; smoking intervention; sylvic acid; treatment utilization; tribal reservation; urban area; youngster",Indoor woodsmoke PM and asthma: a randomized trial,,16336,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,3,342940,
7798934,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES016358-02,,NIEHS:325650;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,UNIVERSITY PARK,UNITED STATES,VETERINARY SCIENCES,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"OMIECINSKI, CURTIS J;",1880864;,5R01ES016358,04/01/2009,01/31/2013,"1,2-benzanthracene; Accounting; Address; Amino Acids; Automobile Driving; Banking, Tissue; Bay Region; Bay Region (Chemistry); Benz(a)Anthracenes; Benz(b)Phenanthrenes; Biological; Body Tissues; Butadiene; Cancer Causing Agents; Cancer of Lung; Cancers; Carcinogens; Chemical Exposure; Chemicals; Chemoprevention; Chemopreventive; Chemopreventive Agent; Cigarette; Code; Coding System; Common Rat Strains; DNA Alteration; DNA mutation; Data; Disease; Disorder; Dose; Drivings, Automobile; EC 3.3.2.3; EPHX; EPHX1; EPHX1 gene; EPOX; Environmental Pollution; Enzymatic Biochemistry; Enzymes; Enzymology; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Epoxide Hydrolase 1; Epoxide Hydroxylase 1, Microsomal; Epoxide Hydroxylase 1, Microsomal (Xenobiotic); Epoxides; Epoxy Compounds; Exhibits; Exons; Exposure to; Extrahepatic; Future; Gene Alteration; Gene Mutation; Gene Organization; Gene Structure; Gene Structure/Organization; Gene Transcription; Gene variant; Generations; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Transcription; Genetic Variation; Genetic mutation; Genetics, Human; Genotype; Glycols; Human; Human Genetics; Human, General; Hydrocarbons; Hydrolysis; Incidence; Individual; Intermediary Metabolism; Investigation; Isothiocyanates; Laboratories; Liver; Lung Parenchyma; Lung Tissue; Lung diseases; MEH; METBL; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Metabolic Activation; Metabolic Processes; Metabolism; Methods; Microsomal Epoxide Hydrolase; Molecular; Naphthanthracenes; Nature; Oncogens; Paper; Pathway interactions; Phenotype; Play; Polymorphism (Genetics); Polymorphism, Genetic; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Proteins; Pulmonary Cancer; Pulmonary Diseases; Pulmonary Disorder; Pulmonary malignant Neoplasm; RNA Expression; Rat; Rattus; Regulation; Reporting; Research; Research Specimen; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Risk; Risk Factors; Role; Sequence Alteration; Smoke; Smoking Behavior; Specimen; Structure of parenchyma of lung; Sulfaforaphane; Sulforaphane; Testing; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Tissues; Toxic effect; Toxicities; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Urinary System, Urine; Urine; Variant; Variation; Variation (Genetics); Xenobiotic Metabolism; Xenobiotics; allelic variant; aminoacid; anticarcinogenic; base; benz(a)anthracene; benzanthracene; benzo(a)anthracene; benzo(b)phenanthrene; body system, hepatic; cancer risk; design; designing; detoxicate; detoxication; disease/disorder; driving; environmental chemical; environmental contaminant; environmental contamination; experiment; experimental research; experimental study; gene product; genetic element; genetic promoter element; genetic variant; human disease; human tissue; insight; lung cancer; lung disorder; malignancy; methylsulfoxybutylisothiocyanate; naphthanthracene; neoplasm/cancer; novel; organ system, hepatic; pathway; phenanthrene; polymorphism; programs; public health relevance; research study; social role; sulforafan; sulforophane; tumorigenic; urinary",Interindividual Variability in Human Microsomal Epoxide Hydrolase," Project Narrative Microsomal epoxide hydrolase is an enzyme that is present in most tissues and plays a key role in metabolizing numerous environmental chemicals. The genetics and regulation of this enzyme likely determines, in part, the nature and extent of interindividual differences in toxicity that result from chemical exposures, including cancers. This research program will characterize the critical features that account for these differences and investigate their roles as risk modifiers of human diseases.",16358,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,2,325650,
7766284,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES016548-03,,NIEHS:336353;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,MINNEAPOLIS,UNITED STATES,NONE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"DONG, ZIGANG ;",1869890;,5R01ES016548,02/01/2008,01/31/2013,"ATP[{..}]protamine O-phosphotransferase; Address; Amino Acids; Animal Welfare; Arsenic; Bibliography; Cancer Causing Agents; Cancer Induction; Carcinogens; Computer Simulation; Computerized Models; Country; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Goals; Histone H3; Histone Kinase; Histones; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Models, Computer; Names; Oncogens; Phosphorylation; Play; Point Mutation; Principal Investigator; Programs (PT); Programs [Publication Type]; Protamine Kinase; Protein Phosphorylation; Research; Research Ethics Committees; Research Resources; Resources; Role; Screening procedure; Simulation, Computer based; Skin Carcinogenesis; Structure; Vertebrate Animals; Vertebrates; abstracting; aminoacid; cancer chemoprevention; carcinogenesis; cell transformation; chemoprevention of cancer; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; expiration; human subject; in silico; inhibitor; inhibitor/antagonist; programs; screening; screenings; social role; transformed cells; ultraviolet; upstream kinase; vertebrata; virtual simulation",The role of histone phosphorylation in arsenic-induced cell transformation and sk,,16548,CDP,Chemo/Dietary Prevention Study Section,,3,336353,
7763826,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES016666-03,,NIEHS:436742;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,GALVESTON,UNITED STATES,BIOCHEMISTRY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"PRAKASH, SATYA ;",1898218;,5R01ES016666,04/01/2008,01/31/2013,"2-Amino-6-Hydroxypurine; 2-Propenal; 3,4-Benzopyrene; 3,4-Benzpyrene; 6H-Purin-6-one, 2-amino-1,7-dihydro-; Acraldehyde; Acrolein; Acrylaldehyde; Acrylic Aldehyde; Affect; Aldehydes; Allyl Aldehyde; Amino Acids; Apoenzymes; Arginine; Arginine, L-Isomer; Benzo(a)pyrene; Binding; Binding (Molecular Function); Biochemical; Biochemical Genetics; Butadiene; Bypass; Cancer Biology; Cancer Induction; Cancers; Carcinogen-DNA Adducts; Carcinogens, Environmental; Causality; Cells; Chemicals; Complement; Complement Proteins; Complex; DNA; DNA Adducts; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Injury; DNA Polymerases; DNA Replicating Damage; DNA Replication; DNA Replication Damage; DNA Synthesis; DNA biosynthesis; DNA lesion; DNA repair protein; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; EC 2.7.7.7; Environmental Carcinogens; Environmental Pollutants; Epoxides; Epoxy Compounds; Ethylene Aldehyde; Etiology; Eukaryota; Eukaryote; Exposure to; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Genome Stability; Genomics; Glycols; Goals; Guanine; Human; Human, General; Hydrogen Bonding; Incidence; L-Arginine; Lesion; Lipid Peroxidation; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Minor Groove; Molecular Interaction; Mutate; Mutation; Nucleotides; Plasmids; Polymerase; Prevention; Proteins; Reaction; Role; Site; Specificity; Stability, Genomic; Structure; Testing; Yeasts; acryaldehyde; adduct; aminoacid; base; cancer prevention; carcinogenesis; disease causation; disease etiology; disease/disorder etiology; disorder etiology; eukaryotida; gene product; genome mutation; in vivo; insight; malignancy; neoplasm/cancer; nucleotide analog; oxidative damage; social role; synthetic DNA; synthetic construct",Role of Rev1 in error-free replication of DNA damage and in mutation prevention,,16666,CE,Cancer Etiology Study Section,,3,436742,
7792337,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES016772-02,,NIEHS:596413;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,DURHAM,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"HOYO, CATHRINE ;",7625416;,5R01ES016772,04/01/2009,01/31/2014,"21+ years old; ASM; ASM1; Address; Adult; Affect; Age; Alleles; Allelomorphs; Animals; Barker Hypothesis; Binding Sites; Birth; Blood; Blood Serum; Blood erythrocyte; Blood normocyte; Blood, Cord; Cancers; Cardiovascular Diseases; Cell Line; Cell Lines, Strains; CellLine; Cells; Characteristics; Chronic Disease; Chronic Illness; Cohort Studies; Cola; Combining Site; Concurrent Studies; Consensus; Cyanocobalamin; Cyanocobalamin (Vitatmin B12); D11S813E; DNA; DNA Methylation; DNA Sequence; Data; Deoxyribonucleic Acid; Development; Diabetes Mellitus; Diet; Dietary Supplementation; Disease; Disorder; Drosophila; Drosophila genus; Endocrine; Environment; Environmental Exposure; Environmental Factor; Environmental Risk Factor; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Erythrocytes; Erythrocytic; Event; Exhibits; Exposure to; FeBAD; Fetal Basis of Adult Disease; Fetal Origin of Adult Disease; Folate; Frequencies (time pattern); Frequency; Fruit Fly, Drosophila; GFAC; Gene Action Regulation; Gene Copy Number; Gene Deregulation; Gene Dosage; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Imprinting; Genetic Transcription; Genetic defect; Genital System, Male, Prostate; Genomic Imprinting; Genus Cola; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H19; H19 gene; Haploid; Haploidy; Height; Hereditary; Homolog; Homologous Gene; Homologue; Human; Human Prostate; Human Prostate Gland; Human, Adult; Human, General; IGF-2; IGF-II; IGF2; Infant; Infrastructure; Inherited; Insulin-Like Growth Factor 2; Insulin-Like Growth Factor II; Insulin-Like Somatomedin Peptide II; Intake; Intercistronic Region; Intermediary Metabolism; Intervention; Intervention Strategies; Last Trimester; Laws; Lead; Life; METBL; MGC4485; Malignant Neoplasms; Malignant Tumor; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Maternal Exposure; Maternal Nutrition; Measurement; Metabolic Processes; Metabolism; Methods; Methylation; Micronutrients; Modification; Multiplication-Stimulating Activity; Multiplication-Stimulating Factor; Mutation; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurobion; Nutrient; Nutrition; Nutritional; Nutritional Science; Obesity; Obesity associated cancer; Obesity associated disease; Obesity related cancer; Obesity related disease; Oncogene Deregulation; Origin of Adult Disease; Parental Imprinting; Parents; Parturition; Pattern; Pb element; Phenotype; Play; Population; Predisposition; Pregnancy Trimester, Third; Pregnant Women; Prevalence; Prostate; Prostate Gland; Prostatic Gland; Protein Methylation; Proteins; Public Health; Pyridoxine (Vitamin B6); Questionnaires; RNA Expression; Reactive Site; Recruitment Activity; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regions, Intergenic; Regulatory Element; RegulatoryElement; Relaxation; Reporting; Research Infrastructure; Research Priority; Research Specimen; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Risk; Risk Factors; Rodent; Rodentia; Rodentias; Role; Science of nutrition; Serum; Somatomedin A; Somatomedin MSA; Specimen; Susceptibility; Therapeutic; Third Pregnancy Trimester; Tissue Growth; Transcription; Transcription, Genetic; Trimester, Third; Umbilical Cord Blood; United States National Institutes of Health; VIT B12; VIT B6; Variant; Variation; Vitamin B; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B12; Vitamin B6; Weight; Weight Gain; Weight Increase; Woman; adiposity; adult human (21+); blood corpuscles; body weight gain; body weight increase; cardiovascular disorder; chronic disease/disorder; chronic disorder; corpulence; corpulency; corpulentia; cultured cell line; diabetes; disease/disorder; early childhood; environmental risk; fetal cord blood; fortification; fruit fly; gene discovery; gene function; gene product; genetic variant; genome mutation; heavy metal Pb; heavy metal lead; imprint; in utero; infant nutrition; interventional strategy; malignancy; maternal nutrition during pregnancy; methyl group; mother nutrition; neoplasm/cancer; nutrition; obese; obese people; obese person; obese population; obesity in children; obesity risk; offspring; ontogeny; pregnant; prenatal; public health medicine (field); public health relevance; recruit; response; social role; surveillance study; unborn; uptake; vitamin B12 compound; wt gain","Nutrition, Deregulation of Imprinted Genes"," PROJECT NARRATIVE This longitudinal epidemiology project will study how prenatal and early childhood nutrition affect the function of genes believed to play role in the development of obesity and obesity-related chronic disease. Because nutrition-related patterns of gene deregulation are potentially reversible, identifying nutritional and other risk factors associated with abnormal gene functioning may lead to therapeutic and public health interventions for childhood obesity and for adult onset, obesity-related chronic diseases.",16772,PN,Pregnancy and Neonatology Study Section,,2,596413,
7810729,R01,ES,5,,02/01/2010,01/31/2011,PA-07-070,5R01ES017022-02,,NIEHS:270904;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ANN ARBOR,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"O'NEILL, MARIE SYLVIA;",8354293;,5R01ES017022,05/01/2009,01/31/2014,"2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; AHH; AHRR; Accounting; Address; Age; Air; Air Pollutants; Air Pollution; Antioxidants; Area; Aromatic Polycyclic Hydrocarbons; Attenuated; Biological; Birth; Birth Weight; Birth length; Blood; Blood Sample; Blood specimen; Blood, Cord; C element; CP11; CY11; CYP1; CYP1A1; CYP1A1 gene; Carbon; Carbon Monoxide; Carcinogen-DNA Adducts; Causality; Cell Line; Cell Lines, Strains; CellLine; Characteristics; Child health care; Cities; Clinical; Clinical Data; Collaborations; Complement; Complement Proteins; Cotinine; DFN7; DNA; DNA Adducts; DNA Damage Repair; DNA Molecular Biology; DNA Repair; Data; Deoxyribonucleic Acid; Developing Countries; Developing Nations; Development; Diet; Dietary intake; Dose; Education; Educational aspects; Endotoxins; Environmental Exposure; Environmental Health; Environmental Health Science; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Etiology; Exposure to; FAEES3; Fatty Acid Ethyl Ester Synthase III Gene; Fetal Age; Fetal Maturity, Chronologic; Food; Future; GST1; GST3; GST3 Gene; GSTM1; GSTM1 gene; GSTP1; GSTP1 gene; GSTPP; GSTT1; GSTT1 gene; Generalized Growth; Genetic Polymorphism; Gestation; Gestational Age; Glutathione S-Transferase M1 Gene; Glutathione S-Transferase Pi Gene; Goals; Growth; Head circumference; Health; Health, Child; Health, Infant; Height; History; Home; Home environment; Human; Human, General; In Vitro; Individual; Infant; Infant Health; Infant Mortality; Infant Mortality Total; Intake; Knowledge; Length; Less-Developed Countries; Less-Developed Nations; Life Cycle; Life Cycle Stages; Location; Man (Taxonomy); Man, Modern; Marital Status; Measures; Mediating; Metals; Methods; Mexico; Modification; Molecular Biology; Monitor; Mothers; National Institute of Environmental Health Sciences; Nitrogen Dioxide; Nitrogen Peroxide; Nitrogen oxide (NO2); Nutritional status; Outcome; Oxidants; Oxidizing Agents; Ozone; P1-450; P450-C; P450DX; P450D\X; PAH; Participant; Particle Size; Particulate; Parturition; Patient Self-Report; Pattern; Personal Satisfaction; Policy Maker; Pollution; Polycyclic Hydrocarbons, Aromatic; Polymorphism (Genetics); Polymorphism, Genetic; Polynuclear Aromatic Hydrocarbons; Population; Postneonatal Mortality; Pregnancy; Pregnancy Outcome; Pregnant Women; Prevention; Preventive Intervention; Public Health; Publishing; Recording of previous events; Registries; Research; Reticuloendothelial System, Blood; Risk; Risk Factors; Sampling; Scientist; Scotine; Seasons; Self-Report; Site; Source; Study of epidemiology; Sulfur Dioxide; Sulfurous Anhydride; Third-World Countries; Third-World Nations; Time; Tissue Growth; Tobacco smoke; Toxicology; Umbilical Cord Blood; Under-Developed Countries; Under-Developed Nations; Unscheduled DNA Synthesis; Vitamin E; Vitamins; Weight; Woman; Work; Xenobiotic Metabolism; adduct; anti-oxidant; base; biomarker; cohort; cultured cell line; disease causation; disease etiology; disease/disorder etiology; disorder etiology; electron acceptor; epidemiology study; fetal cord blood; genetic profiling; global environment; global environmental; improved; in vivo; interest; life course; metropolitan; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; parity; particle; particle exposure; pollutant; polymorphism; polynuclear aromatic hydrocarbon; prenatal exposure; prenatally exposed; preventional intervention strategy; public health medicine (field); public health relevance; trafficking; well-being",Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City,,17022,IRAP,"Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section",,2,270904,
7756610,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY001778-33,,NEI:563471;,2010,NATIONAL EYE INSTITUTE,,NASHVILLE,UNITED STATES,ANATOMY/CELL BIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CASAGRANDE, VIVIEN A;",1865005;,5R01EY001778,02/01/1978,01/31/2014,"Adopted; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Area; Area striata; Area striata structure; Automobile Driving; Axon; Axon Terminals; Biological Neural Networks; Brain; Brain region; Cells; Communication; Complex; Cortex, Striate; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Dorsal; Drivings, Automobile; Dysfunction; Encephalon; Encephalons; Evolution; Exhibits; Feedback; Functional disorder; Generations; Goals; Human; Human, General; Intermediary Metabolism; Investigation; Lateral Geniculate Body; Light; METBL; Mammals, Primates; Man (Taxonomy); Man, Modern; Mediating; Mental disorders; Mental health disorders; Metabolic Processes; Metabolism; Microscopic; Modeling; Morphology; Motion; Nature; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neurons; Output; Pathway interactions; Pattern; Photoradiation; Physiopathology; Play; Presynaptic Terminals; Primary Senile Degenerative Dementia; Primary visual cortex; Primates; Process; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Pulvinar; Pulvinar structure; Relative; Relative (related person); Research; Role; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Shapes; Staging; Striate area; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; System; System, LOINC Axis 4; Testing; Thalamic Nuclei; Thalamic structure; Thalamus; Unspecified Mental Disorder; V1 neuron; Visual; Visual Cortex; Visual System; Visual system structure; Work; area V2; area striata; dementia of the Alzheimer type; dementia praecox; disease/disorder; driving; extrastriate; extrastriate visual cortex; in vivo; information processing; lateral geniculate; lateral geniculate nucleus; mental illness; neural network; neurochemistry; neuronal; object recognition; pathophysiology; pathway; primary degenerative dementia; psychological disorder; public health relevance; pulvinar thalami; response; schizophrenic; senile dementia of the Alzheimer type; social role; thalamic; visual cortical",Visual System Organization and Development," Visual brain areas that are concerned with object recognition and complex motion are among the brain regions that have enlarged the most during the course of human evolution. One of these areas, the pulvinar, has recently been found to be severely affected in Alzheimer's disease and also to be involved in aspects of schizophrenia, yet very little is known about what this area does. The goal of this project is to understand the function of the pulvinar and its contribution to visual cortex.",1778,CVP,Central Visual Processing Study Section,,33,563471,
7747981,R01,EY,5,,12/01/2009,11/30/2010,PA-07-070,5R01EY002874-26,,NEI:382388;,2010,NATIONAL EYE INSTITUTE,,SAN FRANCISCO,UNITED STATES,PHYSIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"STRYKER, MICHAEL PAUL;",1875263;,5R01EY002874,12/01/1978,11/30/2013,"21+ years old; Adolescent; Adolescent Youth; Adult; Agreement; Amblyopia; Animal Model; Animal Models and Related Studies; Animals; Assay; Basic Research; Basic Science; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; CNS plasticity; Ca++ element; Calcium; Cats; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Coagulation Factor IV; DNA Alteration; DNA Sequence Rearrangement; DNA mutation; Dependence; Development; Domestic Cats; Electrodes, Miniaturized; Electromagnetic, Laser; Electroporation; Experimental Models; Experimental Models, Other; Eye; Eyeball; Factor IV; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Ferrets; Frequencies (time pattern); Frequency; Future; Gene Alteration; Gene Mutation; Genetic; Genetic mutation; Goals; Height; Human; Human, Adult; Human, General; Image; Individual; Intracellular Communication and Signaling; Label; Laboratories; Laser Scanning Microscopy; Lasers; Mammals, Cats; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Microelectrodes; Microscope; Microscopy; Models, Experimental; Molecular; Monkeys; Morphology; Murine; Mus; Mutant Strains Mice; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Growth Factor Receptors; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Neurotrophic Factor Receptor; Ocular dominance columns; Optics; Patients; Peptide Biosynthesis, Ribosomal; Pharmacology; Phase; Phorias; Photic Stimulation; Photons; Population; Predisposition; Prevention; Process; Progress Reports; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis Inhibition; Protein Synthesis, Ribosomal; Radiation, Laser; Rearrangement; Receptors, N-Methylaspartate; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neurotrophin; Recovery; Reports, Progress; Research; Role; Scanning; Scanning Microscopy, Laser; Sequence Alteration; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Space Perception; Spatial Discrimination; Squint; Staging; Strabismus; Susceptibility; Synapses; Synaptic; Techniques; Testing; Time; Translations; VESCL; Vesicle; Visual; Visual Cortex; Visual Stimulation; Visual System; Visual system structure; Work; adult human (21+); base; biological signal transduction; calcium indicator; cell type; critical period; deprivation; excitatory neuron; extracellular; imaging; in utero; in vivo; juvenile; juvenile human; millimeter; model organism; monocular; monocular deprivation; mouse mutant; neural; neural circuit; neural circuitry; neural plasticity; neuronal; neuroplasticity; optic imaging; optical imaging; perceptual spatial orientation; presynaptic; prevent; preventing; protein synthesis; public health relevance; receptive field; relating to nervous system; repair; repaired; response; restoration; social role; spatial orientation; spatial orientation (perception); spatial perception; visual cortical; visual deprivation",Development and Plasticity of the Visual System," Item 7. Project Narrative (relevance)  The long term goal of the proposed research is to understand the cellular mechanisms and changes in the circuitry of the visual cortex that are responsible for the loss of influence of the deprived eye in experimental models of amblyopia, and to determine what is the potential for recovery. Much of the basic science in this field has concentrated on animal models of deprivation amblyopia, of which there are many, in the hope that an understanding of the neural signaling and circuit bases of plasticity would enlighten further attempts at prevention and treatment in human patients. This proposal, by identifying mechanisms that operate in different phases of plasticity and by identifying the origins of the difference between the repair potential of juvenile and visual adult cortex, should be valuable in guiding future attempts at therapy for visual cortical abnormalities.",2874,CVP,Central Visual Processing Study Section,,26,382388,
7765534,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY004432-24,,NEI:324963;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,PSYCHOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"PELLI, DENIS G;",1965050;,5R01EY004432,07/01/1982,01/31/2011,"0-11 years old; 21+ years old; Accounting; Address; Adult; Age; Algorithms; Apoplexy; Area; Bears; Brain; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Child; Child Youth; Children (0-21); Classification; Cognition; Computer Simulation; Computer-Assisted Image Analysis; Computerized Models; Connectionist Models; Crowding; Data; Detection; Diagnostic; Encephalon; Encephalons; Frequencies (time pattern); Frequency; Fruit; Functional Magnetic Resonance Imaging; Fusiform gyrus; Generalized Growth; Grant; Growth; Human; Human, Adult; Human, Child; Human, General; Image; Image Analyses, Computer-Assisted; Knock-out; Knockout; Learning; Learning, Machine; Left; Letters; Link; Literature; MRI, Functional; Machine Learning; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mediating; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Names; Nervous System, Brain; Neural Network Models; Neural Network Simulation; Neural Networks (Computer); Noise; Occipital-Temporal Gyrus; Perception; Perceptrons; Performance; Physiology; Probability; Problem Solving; Process; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Reader; Reading; Schools; Simulation, Computer based; Solutions; Stimulus; Stroke; Sum; Survey Instrument; Surveys; Systematics; TXT; Techniques; Testing; Text; Time; Tissue Growth; Transmission; Ursidae; Ursidae Family; Vascular Accident, Brain; Visual System; Visual system structure; Weight; Work; adult human (21+); brain attack; cerebral vascular accident; children; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; content based retrieval; detector; dietary fruit; experiment; experimental research; experimental study; fMRI; feature detection; feature recognition; imaging; in silico; insight; kernel methods; neural network (computer simulation of nervous system); object recognition; ontogeny; parallel processing; peripheral reading; psycho-physiological; receptive field; research study; response; statistical learning; stroke; support vector machine; theories; tool; transmission process; virtual simulation; youngster",Transmission of Information in the Visual System,,4432,CVP,Central Visual Processing Study Section,,24,324963,
7759128,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY008520-15,,NEI:356226;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,NONE,18,036837920,US,TX,772045037,UNIVERSITY OF HOUSTON,"APPLEGATE, RAYMOND A;",1867514;,5R01EY008520,04/01/1991,01/31/2011,"Age-Years; Analysis, Data; Blindness; Cataract; Clinical; Computer Simulation; Computerized Models; Data; Data Analyses; Detection; Development; Disease; Disorder; Eye; Eyeball; Funding; Future; Goals; Image; Investigators; Longitudinal Studies; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Methods; Metric; Models, Computer; Monitor; Optics; Patients; Population; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Research; Research Personnel; Researchers; Retinal; Simulation, Computer based; Speed; Speed (motion); Testing; Time; Validation; cataractogenesis; cataractous lenses; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; disease/disorder; imaging; improved; in silico; intervention design; long-term study; programs; therapy design; tool; treatment design; virtual simulation; visual performance",Aberrations of eyes in normal and clinical populations,,8520,AED,Anterior Eye Disease Study Section,,15,356226,
7780356,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY009052-16,,NEI:680924;,2010,NATIONAL EYE INSTITUTE,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"RABINOWITZ, YARON SOLOMON;",1969864;,5R01EY009052,01/01/1993,01/31/2013,"AQP5 protein; Active Follow-up; Affect; Biologic Marker; Biological Markers; Candidate Disease Gene; Candidate Gene; Causality; Chromosome 4; Chromosome Mapping; Chromosomes, Human, Pair 4; Clinical; Complex; Cornea; Corneal Diseases; Corneal Disorder; Data; Data Linkages; Development; Diagnosis; Dilatation; Dilatation, Pathologic; Discriminant Analyses; Discriminant Analysis; Early Diagnosis; Ectasia; Epithelial Cells; Epithelium, Anterior Corneal; Epithelium, Corneal; Etiology; Family; GWAS; Gene Expression; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, Gene Mapping; Genotype; Goals; Grant; Haplotypes; Individual; Keratoconus; Laboratories; Learning, Machine; Link; Linkage Analysis; Linkage Mapping; Linkages, Data; Literature; Machine Learning; Maps; Molecular Marker; Mutation; Nature; Pathogenesis; Pathological Dilatation; Patients; Phenotype; Polymorphism, Single Base; Predisposition; Predisposition gene; Public Health; Publishing; Record Linkage Study; Relative; Relative (related person); SNP; SNPs; Sampling; Scanning; Screening procedure; Signature Molecule; Single Nucleotide Polymorphism; Structure of corneal epithelium; Study Subject; Surgery, Unnecessary; Susceptibility; Susceptibility Gene; Testing; Time; Transplantation; Unnecessary Surgery; Videokeratographies; Videokeratography; Work; aquaporin 5; association test; biomarker; case control; cohort; cornea disorder; corneal; corneal epithelial; corneal epithelium; disease causation; disease etiology; disease/disorder etiology; disorder etiology; early detection; family based linkage study; follow-up; forest; genetic association; genetic linkage analyses; genetic linkage analysis; genetic mapping; genetic variant; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide linkage; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; improved; indexing; kernel methods; linkage analyses; predisposing gene; prevent; preventing; public health medicine (field); screening; screenings; statistical learning; success; support vector machine; tool; transplant; whole genome association studies; whole genome association study",Genetic Factors in Keratoconus,,9052,AED,Anterior Eye Disease Study Section,,16,680924,
7751254,R01,EY,5,,01/01/2010,12/31/2010,,5R01EY009171-16,,NEI:297615;,2010,NATIONAL EYE INSTITUTE,,KANSAS CITY,UNITED STATES,PHARMACOLOGY,05,010989619,US,MO,64110,UNIVERSITY OF MISSOURI KANSAS CITY,"MITRA, ASHIM K;",6783677;,5R01EY009171,11/01/1994,12/31/2010,"(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid; 1, 2-Dehydrocortisone; 1,2-Dehydrohydrocortisone; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 6-Methylprednisolone; 6Alpha-Methylprednisolone; 9-((2-Hydroxyethoxy)methyl)guanine; ABCB1; ATP-Binding Cassette, Sub-Family B Proteins; ATP-Binding Cassette, Sub-Family B, Member 1; Absorption; Acicloftal; Aclovir; Acute; Acycloguanosine; Acyclovir; Adrenal Cortex Hormones; Affinity; Amino Acid Channel; Amino Acid Transport Systems; Amino Acid Transporter; Amino Acids; Aminoacetic Acid; Anterior Chamber; Anterior Chamber of the Eye; Anterior chamber of eye structure; Anti-Bacterial Agents; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antiinflammatories; Antiinflammatory Agents; Antioxidants; Antiviral Agents; Antiviral Drugs; Antivirals; Applications Grants; Ascorbic Acid; Bioavailability; Biologic Availability; Biological Availability; Body Tissues; CMV; Cargosil; Cell Culture Techniques; Cells; Chinidin; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Conscious; Consciousness; Cornea; Corticoids; Corticosteroids; Cytomegalovirus; DNA; Dehydrocortisone; Delta(1)-Cortisone; Delta(1)Hydrocortisone; Delta-F; Delta1-dehydro-hydrocortisone; Deltacortisone; Deltadehydrocortisone; Deltahydrocortisone; Deoxyribonucleic Acid; Drug Administration, Topical; Drug Precursors; Drug resistance; Drugs; E-Mycin; Epithelial; Epithelial Cells; Epithelium, Anterior Corneal; Epithelium, Corneal; Ery-Tab; Eryc; Eryderm; Erythrocin; Erythromycin; Erythromycin A; Esters; Exhibits; Fluoroquinolones; Funding; Glaxo Wellcome Brand of Aciclovir; Glaxo Wellcome Brand of Aciclovir Sodium Salt; Glutamates; Glycine; Grant; Grant Proposals; Grants, Applications; HCMV; HHV-1; HHV-2; HSV; HSV-1; HSV-2; HSV1; HSV2; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus 2; Herpes Simplex Virus Type 1; Herpes Simplex Virus Type 2; Herpes labialis Virus; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus hominis; Herpesvirus progenitalis; Herpesviruses; Human; Human (alpha) herpes virus 2; Human Herpesvirus 2; Human herpes simplex virus type 1; Human herpes simplex virus type 2; Human herpesvirus 1; Human herpesvirus type 1; Human, General; Hydrolysis; INFLM; Ilotycin; In Vitro; Inflammation; Investigators; Keratitis; L-Ascorbic Acid; L-Glutamate; L-Phenylalanine; L-Valine; Laboratories; Lead; Levaquin; Levofloxacin; Liquid substance; Lytotoxicity; MDR1 Protein; Macrolides; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane; Metacortandracin; Metacortandralone; Methods and Techniques; Methods, Other; Methyl prednisolone; Methylprednisolone; Methylprednisolonum; Metipred; Microdialysis; Miscellaneous Antibiotic; Modeling; Molecular; Multidrug Resistance 1; Multidrug Resistance Protein 1; Multidrug Resistance Proteins; Multidrug Resistant Proteins; NIAID; National Institute of Allergy and Infectious Disease; Ofloxacin; Ofloxacin, (S)-Isomer; Oryctolagus cuniculus; P-GP; P-Glycoprotein; P-Glycoprotein 1; P-Glycoprotein Transporter; P-Glycoproteins; PGY-1 Protein; Parke Davis Brand of Aciclovir; Pb element; Pediamycin; Penetration; Peptides; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenylalanine; Phenylalanine, L-Isomer; Physiologic Availability; Poviral; Prednisolonum; Prednisone; Prednisonum; Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-; Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-; Pro-Drugs; Process of absorption; Prodrugs; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Quinidine; Quixin; RNA Viruses; RP-Mycin; Rabbit, Domestic; Rabbits; Reporting; Research; Research Contracts; Research Institute; Research Personnel; Researchers; Robimycin; Role; Salivary Gland Viruses; Simplexvirus; Solubility; Steroid Compound; Steroids; Structure of corneal epithelium; System; System, LOINC Axis 4; Techniques; Therapeutic; Therapeutic Corticosteroid; Time; Tissues; Topical application; Treatment Efficacy; VIT C; Valine; Viral; Viral Diseases; Virorax; Virus Diseases; Vitamin C; Warner Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir Sodium Salt; Zovirax; Zovirax for Injection; absorption; aminoacid; anterior chamber; anti-bacterial; anti-microbial agent; anti-microbial drug; anti-oxidant; antibacterial; antimicrobial agent; antimicrobial drug; ascorbate; bioavailability of drug; corneal; corneal epithelial; corneal epithelium; cytomegalovirus group; cytotoxicity; delta-Cortisone; design; designing; drug resistant; drug/agent; efflux pump; eye center; fluid; gene product; heavy metal Pb; heavy metal lead; herpes simplex i; herpes simplex ii; herpes virus; herpes virus 1, human; herpesvirus; human alphaherpesvirus 1; human alphaherpesvirus 2; human cytomegalovirus; human herpesvirus 1 group; improved; in vivo; inhibitor; inhibitor/antagonist; lipophilicity; liquid; membrane structure; novel; nucleoside analog; prednisolone; programs; resistance to Drug; resistant to Drug; social role; therapeutic efficacy; therapeutically effective; topical administration; topical drug application; topically applied; uptake; viral infection; virus infection",Ocular Disposition of Antimicrobial Agents,,9171,GDD,Gene and Drug Delivery Systems Study Section,,16,297615,
7752784,R01,EY,5,,01/01/2010,12/31/2010,,5R01EY009339-21,,NEI:382388;,2010,NATIONAL EYE INSTITUTE,,CLEVELAND,UNITED STATES,PHARMACOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"PALCZEWSKI, KRZYSZTOF NMI;",1960297;,5R01EY009339,08/01/1992,12/31/2011,"11 cis Retinal; 2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; Abbreviations; Acids; Acyl CoA; Acyl Coenzyme A; Acyltransferase; Adipocytes; Adipose Cell; Affinity Chromatography; Age related macular degeneration; Alcohol Dehydrogenase (NAD+); Alcohol dehydrogenase; Alcohol-NAD+ Oxidoreductase; All-Trans-Retinol; Anti-Infective vitamin; Antixerophthalmic vitamin; Axerophthal; Axerophthol; Axerophtholum; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biochemical Process; Biological Preservation; Biosterol; Bis-Tris; Bistris; Body Tissues; Brain; Carotenes and Carotenoids; Carotenoids; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; Charge; Chemicals; Choline Chloride Dihydrogen Phosphate; Choline Glycerophospholipids; Choline Phosphate; Choline Phosphate Chloride; Choline Phosphoglycerides; Chromatography, Affinity; Complex; Cone; Cones (Eye); Cones (Retina); Coupled; DAGAT enzyme; DGAT1; Dark Adaptation; Data; Dehydrogenases; Detergents; Development; Diacylglycerol O-acyltransferase 1; Disease; Disorder; EC 2.3; Electron Microscopy; Electroretinography; Encephalon; Encephalons; Endoplasmic Reticulum; Enzymes; Ergastoplasm; Esters; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride; Exhibits; Eye; Eyeball; Face; Fat Cells; Fatty Acyl CoA; Foundations; G protein-coupled receptor RGR; GRK1 protein; GeneHomolog; Genes; Genetic; Genetically Engineered Mouse; Heart; Homolog; Homologous Gene; Homologue; Human; Human, General; Illumination; Impairment; Intracellular Communication and Signaling; Investigators; Isotope Labeling; Label; Lard-Factor; Lead; Learning; Leber abiotrophy; Leber congenital amaurosis; Leber congenital amaurosis (LCA); Leber congenital tapetoretinal degeneration; Leber disease 2; Leber's amaurosis; Leber's congenital amaurosis; Leber's disease; Lecithin; Life; Ligand Binding Protein; Ligands; Light; Lighting; Lipids; Lipocytes; Long-Chain Acyl CoA; Maculopathy, Age-Related; Mammals, Mice; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mature Lipocyte; Mature fat cell; Membrane; Membrane Protein Traffic; Membrane Traffic; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods; Mice; Microscopy; Molecular; Molecular Interaction; Murine; Mus; Natural regeneration; Nervous System, Brain; Oleovitamin A; Ophthalamin; Opsin; Outer pigmented layer of retina; Oxidoreductase; Oxygenases; Partial Sight; Pathway interactions; Pb element; Phosphatidylcholines; Phosphocholine; Phosphorylcholine; Phosphorylcholine Chloride; Photometry/Spectrum Analysis, Mass; Photons; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Phototransduction; Physiologic; Physiological; Pigment cell layer of retina; Pigmentary Retinopathy; Pigmented layer of retina; Piperazines; Preservation, Biologic; Preservation, Biological; Process; Production; Programs (PT); Programs [Publication Type]; Propane; Proteins; RPE-retinal G protein-coupled receptor; RPE65; RPE65 protein; Reaction; Reductases; Regeneration; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Retina; Retinal; Retinal Cone; Retinal Pigment Epithelium; Retinal Pigments; Retinal pigment epithelial cells; Retinaldehyde; Retinene; Retinitis Pigmentosa; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Rhodopsin; Rod Outer Segment of the Retina; Rod Outer Segments; Rod-Cone Dystrophy; Rod-Opsin; Rods and Cones; Role; Scotopic Adaptation; Sight; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structural Protein; Structure; Structure of retinal pigment epithelium; System; System, LOINC Axis 4; Tapetoretinal Degeneration; Testing; Tissues; Transgenic Organisms; Universities; Vertebrate Photoreceptors; Vision; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual; Visual Cortex; Visual Perception; Visual Pigments; Visual Purple; Visual Receptor; Visual System; Visual Transduction; Visual impairment; Visual system structure; Vitamin A Alcohol; Vitamin A Aldehyde; Vitamin A USP; acyl-coenzyme A diacyl-glycerol acyltransferase; adduct; affinity purification; amaurosis congenita of Leber; base; biological signal transduction; bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane; chromophore; cone cell; congenital amaurosis of retinal origin; congenital retinal blindness; congenital retinal blindness (CRB); congenital retinitis pigmentosa; diacylglycerol O-acyltransferase; diacylglycerol acyltransferase; diglyceride acyltransferase; disease/disorder; dysgenesis neuroepithelialis retinae; electroretinogram; ethane sulfonate; ethanesulfonic acid; expression cloning; facial; fat metabolism; gene product; heavy metal Pb; heavy metal lead; hereditary epithelial dysplasia of retina; hereditary retinal aplasia; heredoretinopathia congenitalis; immunocytochemistry; in vitro activity; in vivo; light intensity; lipid metabolism; long chain fatty acid; membrane structure; mouse model; mutant; novel; opsin kinase; palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase; palmitoyl-coenzyme A-sn-1,2-diacylglycerol acyltransferase; palmitoylation; particle; pathway; perilipin; photoreceptor degeneration; preservation; programs; regenerate; retina photosensitive pigment; retinal (bacteriorhodopsin); retinal pigment epithelium G protein-coupled receptor; retinol; retinyl ester hydrolase; retinyl esterase; rho; rhodopsin kinase; rod outer segment; senile macular disease; social role; transgenic; two-photon; visual cortical; visual cycle; visual process; visual processing; visually impaired",Retinoids in Vision,,9339,BDPE,Biology and Diseases of the Posterior Eye Study Section,,21,382388,
7744644,R01,EY,5,,01/01/2010,12/31/2010,,5R01EY009852-18,,NEI:338580;,2010,NATIONAL EYE INSTITUTE,,SAINT LOUIS,UNITED STATES,OPHTHALMOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"BASSNETT, STEVEN ;",3067399;,5R01EY009852,09/30/1992,12/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Acids; Animals; Antiheparin Factor; Attention; Binding; Binding (Molecular Function); Biochemistry; Blood Platelet Factor IV; Blood erythrocyte; Blood normocyte; Blood platelet factor 4; Body Tissues; Cataract; Causality; Cell Differentiation; Cell Differentiation process; Cell Nucleus; Cell-Death Protease; Characteristics; Chemistry, Biological; Chemokine (C-X-C motif) Ligand 4; Chickens; Chromatin; Core Particle; Cytoplasm; Cytoplasmic Organelle; Cytoplasmic Structures; DNA; DNase; Data; Deoxyribonucleases; Deoxyribonucleic Acid; Employee Strikes; Enzymes; Erythrocytes; Erythrocytic; Esteroproteases; Etiology; Excision; Extirpation; FLR; Factor 4; Failure (biologic function); Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; HMG-20; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Heparin Neutralizing Protein; High Mobility Protein 20; Human; Human, General; Hydrolysis; ICE-like protease; Investigators; Knock-out; Knockout; Knockout Mice; Laboratories; Lens Fiber; Macropain; Macroxyproteinase; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Multicatalytic Proteinase; Murine; Mus; Mutation; Nucleases, DNA; Nucleosome Core; Nucleosome Core Particle; Nucleus; Null Mouse; Optics; Organelles; Pathway interactions; Pattern; Peptidases; Peptide Hydrolases; Peptides; Phase; Platelet Factor 4; Play; Primary Lesion; Process; Programs (PT); Programs [Publication Type]; Prosome; Proteases; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Proteinases; Proteolytic Enzymes; Proteosome; Recombinant Platelet Factor 4; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Regulation; Removal; Research Personnel; Researchers; Reticuloendothelial System, Erythrocytes; Role; Secondary to; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Strikes; Strikes, Employee; Surgical Removal; Testing; Tissues; Transgenic Animals; Ubiquitin; base; blood corpuscles; caspase; cataractogenesis; cataractous lenses; cystein protease; cystein proteinase; cysteine endopeptidase; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; failure; fiber cell; gamma-Thromboglobulin; genome mutation; in vivo; insight; interest; lens; membrane structure; multicatalytic endopeptidase complex; novel; nuclease; pathway; platelet factor IV; programs; research study; resection; social role",Fiber Cell Formation in Normal and Cataractous Lenses,,9852,ZRG1,Special Emphasis Panel,,18,338580,
7754401,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY010016-17,,NEI:333291;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,PSYCHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"BRAINARD, DAVID H;",10067228;,5R01EY010016,12/01/1992,01/31/2011,"Accounting; Address; Affect; Appearance; Automobile Driving; Behavioral; Cognitive Discrimination; Color; Color Perception; Color Visions; Complex; Data; Detection; Diffuse; Discrimination; Discrimination (Psychology); Drivings, Automobile; Ensure; Environment; Eye; Eyeball; Foundations; Grant; Hand; Human; Human, General; Illumination; Judgment; Light; Lighting; Link; Man (Taxonomy); Man, Modern; Measurement; Measures; Modeling; Nervous; Optics; Perception; Performance; Photoradiation; Play; Process; Property; Property, LOINC Axis 2; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Research; Role; Shapes; Sight; Stimulus; Surface; System; System, LOINC Axis 4; Technology; Testing; Variant; Variation; Vision; Visions, Color; Visual System; Visual system structure; Work; base; color constancy; color processing; computational framework; computer framework; design; designing; driving; experiment; experimental research; experimental study; insight; neural; neural mechanism; neuromechanism; object shape; physical property; psycho-physiological; relating to nervous system; research study; social role; theories",Color Constancy,,10016,CVP,Central Visual Processing Study Section,,17,333291,
7762212,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY012018-13,,NEI:505207;,2010,NATIONAL EYE INSTITUTE,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"MCHAOURAB, HASSANE S;",2095650;,5R01EY012018,02/01/1998,01/31/2013,"Affinity; Aging; Aging Process; Aging-Related Process; Animal Welfare; Appearance; Arts; Bibliography; Binding; Binding (Molecular Function); Cataract; Chaperone; Complement; Complement Proteins; Complex; Country; Crowding; Crystallins; Cysteine; Data; Development; Disulfides; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Funding; Goals; Grant; HSP; Half-Cystine; Heat shock proteins; Hereditary; IACUC; IRBs; Impact, Environmental; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; Interferometry; International; L-Cysteine; Label; Lead; Lens Proteins; Link; Modification; Molecular; Molecular Chaperones; Molecular Interaction; Names; Nuclear; Pb element; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; Research; Research Ethics Committees; Research Resources; Resources; Senescence; Solubility; Staging; Stress Proteins; Structure; Testing; Time; Titrations; Vertebrate Animals; Vertebrates; Weight; abstracting; age dependent; age related; base; catalyst; cataractogenesis; cataractous lenses; congenital cataract; cross-link; crosslink; exhaustion; expiration; fiber cell; gene product; heavy metal Pb; heavy metal lead; human subject; innovate; innovation; innovative; insight; lens; lens transparency; mutant; programs; protein protein interaction; senescent; sensor; tool; vertebrata",Molecular Basis for Lens Transparency,,12018,ZRG1,Special Emphasis Panel,,13,505207,
7777294,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY012118-10,,NEI:1146506;,2010,NATIONAL EYE INSTITUTE,,MIAMI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"PERICAK-VANCE, MARGARET A;",1880743;,5R01EY012118,06/15/2000,01/31/2011,"APOE [{C0003595}]; Active Follow-up; Age; Age related macular degeneration; Alleles; Allelomorphs; Apo-E; ApoE; Apolipoprotein E; Blindness; Candidate Disease Gene; Candidate Gene; Caring; Causality; Cells; Chromosome 1; Chromosome 10; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 10; Clinic; Complement; Complement Proteins; Complex; DNA Resequencing; Data; Data Linkages; Data Set; Dataset; Development; Disease; Disease Progression; Disorder; Environmental Factor; Environmental Risk Factor; Ethnic Origin; Ethnicity; Ethnicity aspects; Etiology; Eye; Eyeball; Family; Frequencies (time pattern); Frequency; Future; Gene Expression; Gene Pool; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genomics; Genotype; Haplotypes; Individual; Intervention; Intervention Strategies; Investigators; Knowledge; Linkage (Genetics); Linkage Disequilibrium; Linkage Disequilibriums; Linkages, Data; Macular degeneration; Macular degenerative disease; Maculopathy, Age-Related; Maps; Methods; Modeling; Ophthalmology; Pathogenesis; Pathway interactions; Patients; Polymorphism (Genetics); Polymorphism Analysis; Polymorphism Detection; Polymorphism, Genetic; Polymorphism, Single Base; Population; Predisposition; Predisposition gene; Programs (PT); Programs [Publication Type]; Record Linkage Study; Recruitment Activity; Reporting; Research Personnel; Researchers; Resequencing; Resolution; Risk Factors; SNP; SNPs; Screening procedure; Single Nucleotide Polymorphism; Smoking; Statistical Methods; Susceptibility; Susceptibility Gene; Testing; Time; Universities; VEGFs; Variant; Variation; Variation (Genetics); Vascular Endothelial Growth Factors; Vegf; allelic variant; base; case control; complement pathway; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environment effect on gene; environmental risk; falls; follow-up; gene discovery; gene environment interaction; genetic epidemiology; genetic linkage; interest; interventional strategy; novel; outreach program; pathway; polymorphism; predisposing gene; programs; recruit; screening; screenings; senile macular disease; sex; socioeconomic; socioeconomically; socioeconomics; tool",Unifying Genetics Epidemiology of Macular Degeneration,,12118,ZRG1,Special Emphasis Panel,,10,1146506,
7768395,R01,EY,5,,03/01/2010,02/28/2011,PA-07-070,5R01EY012204-12,,NEI:291060;,2010,NATIONAL EYE INSTITUTE,,BATON ROUGE,UNITED STATES,BIOLOGY,06,075050765,US,LA,70803,LOUISIANA STATE UNIV A&M COL BATON ROUGE,"GLEASON, EVANNA L;",1908452;,5R01EY012204,07/01/1998,02/28/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Affect; Albers-Schoenberg Disease; Albers-Schonberg disease; Amacrine Cells; Amacrine Cells of Retina; Aminalon; Aminalone; Aminoacetic Acid; Aves; Avian; Birds; Bone; Bone and Bones; Bones and Bone Tissue; Brain; Brain Part; Butanoic acid, 4-amino-; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Membrane; Cellular Physiology; Cellular Process; Cellular Regulation; Chickens; Chloride; Chloride Ion; Chlorides; Cl- element; Connector Neuron; Crossmatching, Tissue; Cytosol; Defect; Disease; Disorder; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Event; Excitatory Synapse; Family; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; GABA; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Inactivation; Gene Silencing; Genes; Glycine; Goals; H+ element; Histocompatibility Testing; Hydrogen Ions; Image; Inhibitory Synapse; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Ions; Kidney; Learning; Link; Marble Bone Disease; Mediating; Membrane; Methods; Mononitrogen Monoxide; Movement; NOS 1 protein; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neurocyte; Neurons; Neurotransmitters; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Osteopetrosis; Osteosclerosis Fragilis; Pathologic; Property; Property, LOINC Axis 2; Proteins; Protons; RNA, Small Interfering; Regulation; Research; Retina; Retinal; Role; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Slice; Small Interfering RNA; Subcellular Process; Synapses; Synaptic; Testing; Tissue Crossmatchings; Tissue Typing; Urinary System, Kidney; Visual; Whole-Cell Recordings; Work; base; biological signal transduction; body movement; bone; cell growth regulation; computer imaging; computerized data processing; data processing; digital imaging; disease/disorder; endothelial cell derived relaxing factor; experience; extracellular; fluorescent dye/probe; gamma-Aminobutyric Acid; gangliocyte; ganglion cell; gene product; histocompatibility typing; imaging; immunocytochemistry; marble bone; member; membrane structure; nNOS enzyme; neuronal; neuronal nitric oxide synthase; novel; renal; siRNA; signal processing; social role; visual process; visual processing",Amacrine Cell Signaling,,12204,BDPE,Biology and Diseases of the Posterior Eye Study Section,,12,291060,
7747980,R01,EY,5,,01/01/2010,12/31/2010,PA-07-070,5R01EY012347-13,,NEI:298660;,2010,NATIONAL EYE INSTITUTE,,DAVIS,UNITED STATES,CHEMISTRY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"AMES, JAMES B;",1937546;,5R01EY012347,01/01/1999,12/31/2011,"Affect; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Blood Coagulation Factor IV; C-terminal; CAR antigen; Ca++ element; Calcium; Calcium Binding; Calcium Ion Signaling; Calcium Signaling; Calcium ion; Calcium-Binding Proteins; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Calorimetry; Cancers; Cell Communication and Signaling; Cell Signaling; Coagulation Factor IV; Combining Site; Complex; Computer Analysis; Cone; Cones (Eye); Cones (Retina); Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Defect; Degenerative Disorder; Deoxyguanylate Cyclase; Disease; Disorder; Drugs; EC 2.7; Factor IV; Family; Fluorescence; GCAP protein; GCAP1 protein; GCAP2 protein; GCAP3 protein; GRK1 protein; GTP pyrophosphate-lyase (cyclizing); GeneHomolog; Generalized Growth; Goals; Growth; Guanyl Cyclase; Guanylate Cyclase; Homolog; Homologous Gene; Homologous Protein; Homologue; Inosinate Cyclase; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Kinases; Light Adaptations; Link; Lipid Bilayers; Macromolecular Structure; Malignant Neoplasms; Malignant Tumor; Medication; Membrane; Membrane Channels; Methods and Techniques; Methods, Other; Molecular Dynamics Simulation; Molecular Interaction; Molecular Structure; N-terminal; NH2-terminal; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Night Blindness; Nuclear Magnetic Resonance; Nyctalopia; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphotransferases; Photoreceptors, Cone; Photoreceptors, Vertebrate; Phototransduction; Physiologic; Physiological; Process; Programs (PT); Programs [Publication Type]; Protein Family; Protein Homolog; ProteinHomolog; Proteins; Publishing; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Regulation; Research; Resolution; Retina; Retinal; Retinal Cone; Retinal Degeneration; Retinal Diseases; Retinal Disorder; Rhodopsin; Rods and Cones; Roentgen Rays; Role; S-modulin; Sight; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Single Crystal Diffraction; Solvents; Spin Labels; Structure; Synapses; Synaptic; Techniques; Tissue Growth; Transphosphorylases; V (voltage); Vertebrate Photoreceptors; Vision; Visual Purple; Visual Transduction; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; Yeasts; biological signal transduction; cancer-associated retinopathy antigen; computational analysis; cone cell; cross-link; crosslink; degenerative condition; degenerative disease; design; designing; disease/disorder; drug/agent; experiment; experimental research; experimental study; gene product; guanylate cyclase activating protein; guanylyl cyclase; guanylyl cyclase activating protein; insight; lipid bilayer membrane; malignancy; membrane structure; microcalorimetry; molecular dynamics; mutant; myristoylation; neoplasm/cancer; nervous system disorder; neurological disease; neuronal; novel; ontogeny; opsin kinase; programs; protein structure; public health relevance; recoverin; recoverin protein; research study; retina degeneration; retina disease; retina disorder; retinal degenerative; retinopathy; rhodopsin kinase; sensitivity-modulating protein; sensor; social role; solid state nuclear magnetic resonance; visual excitation; voltage; working group",Membrane targeting calcium sensors in vision, Calcium ion (Ca2+) controls the excitability of light-sensitive rod and cone cells in the retina and defects in light-dependent calcium signaling are linked to retinal degenerative diseases. The goal of our research is to elucidate the molecular structure and mechanisms of calcium sensor proteins that regulate light-adaptation and disease processes during visual excitation.,12347,ZRG1,Special Emphasis Panel,,13,298660,
7756612,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY012392-10,,NEI:350484;,2010,NATIONAL EYE INSTITUTE,,BERKELEY,UNITED STATES,NONE,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"WILDSOET, CHRISTINE FRANCES;",2283905;,5R01EY012392,01/01/1999,01/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Accounting; Address; Adverse effects; Affect; Amacrine Cells; Amacrine Cells of Retina; Anatomic; Anatomical Sciences; Anatomy; Animals; Antidiabetic Hormone; Assay; Astigmatism; Autoregulation; Aves; Avian; Back; Behavior; Bioassay; Biologic Assays; Biological Assay; Biomechanics; Birds; Birth; Body Tissues; Cavia; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Childhood; Choroid; Clinical; Clinical Trials; Clinical Trials, Unspecified; Compensation; Contact Lenses; Cornea; DNA Molecular Biology; Data; Development; Distant; Dopamine; Dorsum; Drugs; Effectiveness; Epidemic; Exhibits; Exposure to; Expression Profiling; Expression Signature; Eye; Eyeball; Eyeglasses; FLR; Failure (biologic function); Farsightedness; Figs; Figs - dietary; Financial compensation; GCG; GFAC; Gene Expression; Generalized Growth; Genes; Genetic; Glucagon; Glucagon (1-29); Glukagon; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guinea Pigs; HG-Factor; Homeostasis; Human; Human, General; Hydrogen Oxide; Hydroxytyramine; Hyperglycemic-Glycogenolytic Factor; Hypermetropia; Hyperopia; Image; In Vitro; Intracellular Communication and Signaling; Ions; Lead; Left; Length; Light; Link; Literature; Mammalia; Mammals; Mammals, General; Mammals, Guinea Pigs; Mammals, Primates; Man (Taxonomy); Man, Modern; Medication; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Biology; Molecular Fingerprinting; Molecular Profiling; Myopia; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nearsightedness; Nearsightednesses; Nerve; Nerve Transmitter Substances; Nervous; Neurotransmitters; Nutrient; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Outer pigmented layer of retina; Parturition; Pathology; Pattern; Pb element; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Photoradiation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Physiological Homeostasis; Physiology; Pigment cell layer of retina; Pigmented layer of retina; Play; Population; Predisposition; Prevalence; Primates; Process; Property; Property, LOINC Axis 2; Pupil; Receptor Protein; Recycling; Refractive Disorders; Refractive Errors; Regulation; Relative; Relative (related person); Research; Research Design; Retina; Retinal; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoids; Role; Science of Anatomy; Sclera; Shapes; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Spectacles; Stimulus; Structure of retinal pigment epithelium; Study Type; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; Techniques; Testing; Tissue Growth; Tissues; Treatment Side Effects; United States National Institutes of Health; Vision; Visual; Visual Receptor; Waste Products; Water; White of Eye; Work; analog; anatomy; biological signal transduction; cell type; clinical investigation; congenital cataract; corneal; deprivation; design; designing; drug/agent; effective therapy; emmetropization; experience; experiment; experimental research; experimental study; eye refraction disorder; failure; falls; heavy metal Pb; heavy metal lead; image processing; imaging; improved; in vivo; interest; lens; macula; macular; macular edema; molecuar profile; molecular signature; near vision; neovascularization; novel; ontogeny; pediatric; prevent; preventing; public health relevance; receptor; research study; response; side effect; social role; study design; surgery; theories; therapy adverse effect; tool; treatment adverse effect; vision development; visual development; visual system development",Mechanisms underlying emmetropization and local eye growth regulation," Wildsoet, Christine, F: Emmetropization & Local Eye growth Regulation Narrative Emmetropization is the regulatory process that matches the eye's length to its optical power, bringing distant objects to focus on the retina with accommodation relaxed. Myopia, or shortsightedness, represents the failure of emmetropization in which the eye grows too long for its optical power, in near-epidemic prevalence in several populations, with associated with sight-threatening complications, making it critical to understand the determinants of emmetropization, without which effective treatments are unlikely to be developed. This project will apply modern molecular biology and optical techniques to investigate the mechanisms underlying emmetropization, with a view to developing novel treatments for myopia.",12392,ZRG1,Special Emphasis Panel,,10,350484,
7754862,R01,EY,5,,01/01/2010,12/31/2010,,5R01EY012731-08,,NEI:299970;,2010,NATIONAL EYE INSTITUTE,,MILWAUKEE,UNITED STATES,BIOCHEMISTRY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"TWINING, SALLY S;",1862085;,5R01EY012731,08/01/1999,12/31/2011,"ANXA5; Accidents; Address; Adhesions; Agonist; Anchorin CII; Angiogenesis Antagonists; Angiogenesis Blockers; Angiogenesis Inhibitors; Angiogenetic Antagonists; Angiogenic Antagonists; Angiostatic Agents; Angiostatin; Angiostatins; Annexin A5 Protein; Annexin V; Anti-Angiogenetic Agents; Anti-Angiogenic Agents; Anti-Angiogenic Drugs; Antiangiogenesis Agents; Antiangiogenic Agents; Antibodies; Antiproteases; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor I; Blood Coagulation Factor II; Blood Coagulation Factor One; Blood Factor One; Blotting, Western; CBP-I; Calphobindin I; Cell Count; Cell Death, Programmed; Cell Function; Cell Number; Cell Process; Cell division; Cell physiology; Cell-Death Protease; Cell-Extracellular Matrix; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Characteristics; Chemotaxis; Coagulation Factor I; Coagulation Factor II; Coagulation Factor II Receptor; Coagulation Factor One; Cornea; Corneal Injury; Corneal Ulcer; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Cytokines, Chemotactic; Data; Death; Deposit; Deposition; Differentiation Reversal Factor; Disease; Disorder; EC 3.4.21.7; ECM; ELISA; Electromagnetic, Laser; Endonexin II; Endopeptidase Inhibitors; Endopeptidase-Activated Receptors; Enzyme-Linked Immunosorbent Assay; Enzymes; Epithelial; Epithelial Cells; Epithelium, Anterior Corneal; Epithelium, Corneal; Esteroproteases; Extracellular Matrix; F2R; FGF-2; FGF2; Factor I; Factor II; Factor One; Fibrin; Fibrinogen; Fibrinolysin; Fibroblast Growth Factor 2; Fibroblast Growth Factor, Basic; Fibroblasts; Fibrosis; GFAC; Gene Expression; Glu-Plasmin; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF-2; Healed; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Hirudin; Hirudins; Homologous Chemotactic Cytokines; Human; Human, General; ICE-like protease; In Situ Nick-End Labeling; Inhibitors, Angiogenetic; Inhibitors, Angiogenic; Intercrines; Keratectomy, Laser; Keratitis, Ulcerative; Keratomileusis, Laser In Situ; Kringles 1-4 of Plasminogen; LASIK; Laser In Situ Keratomileusis; Laser Intrastromal Keratomileuses; Laser Intrastromal Keratomileusis; Laser-Assisted Stromal In Situ Keratomileusis; Lasers; Lead; Lipocortin-V; Liver; Lung; MMPs; Mammals, Mice; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediating; Membrane; Messenger RNA; Mice; Modeling; Molecular Interaction; Murine; Mus; Myofibroblast; Neovascularization Inhibitors; Operation; Operative Procedures; Operative Surgical Procedures; Organ Culture; Organ Culture Techniques; Oryctolagus cuniculus; PAI-1; PAI1; PAP-I; PAR-1 Receptor; PAR1 Receptor; PDGF; PLANH1; PP4; Patients; Pb element; Peptidase Inhibitors; Peptidases; Peptide Biosynthesis, Ribosomal; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Peptides; Phenotype; Photokeratectomy; Photorefractive Keratectomy; Placental Anticoagulant Protein I; Placental Protein 4; Plasmin; Plasminogen; Plasminogen Activator; Plasminogen Activator Inhibitor 1; Platelet-Derived Growth Factor; Procedures; Profibrinolysin; Prostate Epithelial Cell Growth Factor; Prostatropin; Protease Antagonists; Protease F; Protease Inhibitor; Protease-Activated Receptor 1; Protease-Activated Receptors; Proteases; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteinase Inhibitors; Proteinase-Activated Receptor 1; Proteinase-Activated Receptors; Proteinases; Proteins; Proteolytic Enzymes; Prothrombin; RNA, Messenger; RT-PCR; RTPCR; Rabbit, Domestic; Rabbits; Radiation, Laser; Receptor Activation; Receptor Signaling; Receptor, PAR-1; Receptors, Proteinase-Activated; Respiratory System, Lung; Reverse Transcriptase Polymerase Chain Reaction; Role; SIS cytokines; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Signal Pathway; Stromal Cells; Structure of corneal epithelium; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TUNEL; Testing; Thrombase; Thrombin; Thromboplastin Inhibitor; Time; Type 1 Plasminogen Activator Inhibitor; VAC-Alpha; Vascular Anticoagulant-Alpha; Visual; Western Blotting; Western Blottings; Western Immunoblotting; Wound Healing; Wound Repair; annexin A5; antiangiogenic; bFGF; body system, hepatic; caspase; chemoattractant cytokine; chemokine; cornea ulcer; corneal; corneal epithelial; corneal epithelium; corneal ulceration; corneal wound; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; disease/disorder; experiment; experimental research; experimental study; fibrinogenase; gene product; healing; heavy metal Pb; heavy metal lead; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; intervention development; keratomileusis; mRNA; membrane structure; migration; organ system, hepatic; protein blotting; protein synthesis; pulmonary; regenerate new tissue; regenerating damaged tissue; research study; response; reverse transcriptase PCR; social role; surgery; terminal nick end labeling; therapy development; tissue regeneration; tissue repair; treatment development",Proteases in the Cornea,,12731,AED,Anterior Eye Disease Study Section,,8,299970,
7777766,R01,EY,5,,03/01/2010,02/28/2011,PAR-04-023,5R01EY012893-10,,NEI:2901071;,2010,NATIONAL EYE INSTITUTE,,SYLMAR,UNITED STATES,,28,086470742,US,CA,91342,"SECOND SIGHT MEDICAL PRODUCTS, INC.","GREENBERG, ROBERT JAY;",8617490;,5R01EY012893,07/01/2000,02/28/2011,"Accommodation phosphene; Algorithms; Animal Model; Animal Models and Related Studies; Animal Testing; Animals; Area; Blinded; Body Tissues; Canine Species; Canis familiaris; Chronic; Clinic; Clinical; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Code; Coding System; Collaborations; Common Rat Strains; Computer Programs; Computer software; Development; Development and Research; Devices; Dogs; Effectiveness; Electric Stimulation; Electrical Stimulation; Electrodes; Electrophysiology; Electrophysiology (science); Engineering; Engineerings; Environment; Eye; Eye Movements; Eyeball; FDA approved; Foundations; Funding; Goals; Grant; Head; Head Movements; Human; Human, General; Image; Implant; Institutes; Institution; Investigators; Learning; Location; Macular degeneration; Macular degenerative disease; Mammals, Dogs; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Modeling; Movement; Nervous; Neurophysiology / Electrophysiology; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pattern; Performance; Phase; Phosphenes; Physicians; Physiologic pulse; Physiology; Pigmentary Retinopathy; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; Pulse; R & D; R&D; Rat; Rattus; Relative; Relative (related person); Research; Research Personnel; Researchers; Resolution; Retina; Retinal; Retinal Degeneration; Retinitis Pigmentosa; Rod-Cone Dystrophy; Safety; Scientist; Series; Sight; Software; Surface; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Tapetoretinal Degeneration; Technology; Testing; Tissues; Vision; Work; biomedical implant; blind; body movement; canine; clinical test; computer program/software; design; designing; domestic dog; experiment; experimental research; experimental study; flexibility; human subject; imaging; implant device; implantable device; indwelling device; minimally invasive; model organism; multidisciplinary; neural; next generation; novel; patch clamp; programs; prototype; relating to nervous system; research and development; research clinical testing; research study; retina degeneration; retinal degenerative; retinal prosthesis; safety study; surgery; tool; visual process; visual processing",Research/Development of Artificial Rentinas for the Blind,,12893,ZRG1,Special Emphasis Panel,,10,2901071,
7760887,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY013256-10,,NEI:407347;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"MLODZIK, MAREK ;",6481188;,5R01EY013256,02/01/2001,01/31/2011,"21+ years old; Adult; Apoptosis; Apoptosis Pathway; Area; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Brain; Cancers; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Death, Programmed; Cell Polarity; Cell Signaling; Cells; Cellular Oncogene; Cytoplasmic Domain; Cytoplasmic Tail; Disease; Disorder; Drosophila; Drosophila eye; Drosophila genus; Dsh protein; Elements; Encephalon; Encephalons; Episkopi blindness; Event; Eye; Eye Development; Eye diseases; Eyeball; FZ-3 protein, human; FZD3 Protein; FZD3 protein, human; Family; Flies; Frizzled 3; Frizzled 3 Protein; Frizzled Cystein-Rich Domain; Frizzled Domain; Frizzled, Drosophila, Homolog of, 3; Fruit Fly, Drosophila; Fz Domain; Fz-3; GFAC; Generations; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, Adult; Human, General; Image; Intracellular Communication and Signaling; Ligands; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Medical; Membrane; Modeling; Modification; Molecular; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Norrie disease; Norrie disease (ND); Norrie syndrome; Norrie's disease; Norrie-Warburg syndrome; Notch Signaling Pathway; Nuclear; Outcome; Pathway interactions; Pattern; Phenotype; Phosphorylation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Position; Positioning Attribute; Process; Protein Phosphorylation; Proteins; Proteolysis and Signaling Pathway of Notch; Proto-Oncogenes; Receptor Protein; Recruitment Activity; Regulation; Retina; Retinal; Role; Sight; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stereotyping; Testing; Vision; Visual Receptor; Visual System; Visual system structure; adult human (21+); atrophia bulborum hereditaria; biological signal transduction; c-ONC; cell fate specification; cellular polarity; congenital progressive oculo-acoustico-cerebral degeneration; disease/disorder; dishevelled protein; experiment; experimental research; experimental study; eye disorder; eye morphogenesis; eye primordia; fly; frizzled 3 protein, human; frizzled homolog 3 (Drosophila), human; fruit fly; gene product; hFz3; human FZD3 protein; imaging; in vivo; malignancy; membrane structure; necrocytosis; neoplasm/cancer; neuronal; notch; notch protein; notch receptors; ocular development; ophthalmopathy; pathway; protooncogene; pseudoglioma congenita; receptor; recruit; research study; response; retinotopic; social role; stem cell biology; transcription factor",Ommatidial Patterning during Eye Development,,13256,BDPE,Biology and Diseases of the Posterior Eye Study Section,,10,407347,
7769464,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY013308-09,,NEI:420565;,2010,NATIONAL EYE INSTITUTE,,SEATTLE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"MUSTARI, MICHAEL J.;",1882599;,5R01EY013308,12/01/2000,01/31/2011,"Acceleration; Address; Affect; Animals; Area; Behavior; Behavioral Paradigm; Brain Stem; Brainstem; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cerebellar Nuclei; Cerebellar vermis structure; Cerebellum; Data; Diagnosis; Disease; Disorder; Electric Stimulation; Electrical Stimulation; Eye; Eyeball; Goals; Head; Intracellular Communication and Signaling; Investigators; Linear Regressions; Macaca; Macaque; Maintenance; Maintenances; Mammals, Primates; Medial; Methods; Modeling; Motion; Motor; Movement; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleus; Optic tract structure; Pathway interactions; Patients; Phase; Play; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Population; Primates; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pursuit, Smooth; Regressions, Linear; Research Design; Research Personnel; Researchers; Role; Rotation; SPEM; Science of neurophysiology; Sensory; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Site; Smooth Pursuit; Specificity; Study Type; Study models; Suggestion; System; System, LOINC Axis 4; Tag; Temporal Lobe; Testing; Thalamic structure; Thalamus; Tracer; Tracts, Optic; Vermis of Cerebelli; Vestibular Nuclei; Vestibular nucleus structure; Vision; Visual; Visual Fields; awake; biological signal transduction; body movement; comparative; disease/disorder; frontal eye fields; gaze; neural control; neural regulation; neuronal; neurophysiology; neuroregulation; nucleus reticularis; ocular motor; ocularmotor; oculomotor; pathway; programs; response; smooth pursuit eye movement; social role; study design; temporal cortex; temporal lobe/cortex; thalamic; vermis; visual-vestibular",Neural Control of Visual Vestibular Behavior,,13308,ZRG1,Special Emphasis Panel,,9,420565,
7762215,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY013849-08,,NEI:376200;,2010,NATIONAL EYE INSTITUTE,,BERKELEY,UNITED STATES,NONE,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"GONG, XIAOHUA GONG;",2242484;,5R01EY013849,02/01/2002,01/31/2012,"Affect; Age; Alleles; Allelomorphs; American; Autoregulation; Biochemical; Blindness; Candidate Disease Gene; Candidate Gene; Cataract; Cells; Chromosome 2; Chromosomes; Chromosomes, Human, Pair 2; Communicating Junction; Communication; Connexins; Consomic Mouse Strain; Crystallins; DNA Alteration; DNA mutation; Data; Diabetes Mellitus; Disease; Disorder; Environmental Factor; Environmental Risk Factor; Event; Fiber; Gap Junction Proteins; Gap Junctions; Gene Alteration; Gene Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Goals; Hereditary; Homeostasis; Human; Human, General; Inherited; Knock-out; Knockout; Lens Fiber; Lens Proteins; Light; Link; Low-resistance Junction; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Methods; Mice; Mice, Mutant Strains; Murine; Mus; Mutant Strains Mice; Mutation; Nexus; Nexus Junction; Nuclear; Operation; Operative Procedures; Operative Surgical Procedures; Permeability; Phenotype; Photoradiation; Physiologic; Physiological; Physiological Homeostasis; Point Mutation; Prevention; Property; Property, LOINC Axis 2; Proteins; Regulation; Research; Role; Sequence Alteration; Severities; Solubility; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Xenopus oocyte; age dependent; age related; base; cataractogenesis; cataractous lenses; crystallin, gammaB; diabetes; disease/disorder; environmental risk; fiber cell; gamma-Crystallins; gammaB crystallin; gap junction channel; gene product; genome mutation; in vivo; insight; lens; lens protein; lens transparency; mouse mutant; mutant; new therapeutics; next generation therapeutics; novel therapeutics; prevent; preventing; social role; surgery","Cataractogenesis, Connexin Mutants and Genetic Modifiers",,13849,AED,Anterior Eye Disease Study Section,,8,376200,
7762209,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY014358-09,,NEI:347490;,2010,NATIONAL EYE INSTITUTE,,SEATTLE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"WONG, RACHEL O;",1969754;,5R01EY014358,02/01/2003,01/31/2012,"Ablation; Animal Welfare; Animals; Behavior; Bibliography; Brachydanio rerio; Cell Communication; Cell Components; Cell Function; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Structure; Cell physiology; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Structures; Cone; Cones (Eye); Cones (Retina); Country; Danio rerio; Development; Ecological impact; Electromagnetic, Laser; Embryo; Embryonic; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Foundations; Future; Generations; Glia; Glial Cells; Hour; IACUC; IRBs; Image; Impact, Environmental; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Knowledge; Kolliker's reticulum; Label; Lasers; Lead; Life; Location; Motility; Motility, Cellular; Names; Nerve Cells; Nerve Unit; Neural Cell; Neural Growth; Neural Retina; Neurocyte; Neuroglia; Neuroglial Cells; Neuronal Growth; Neurons; Non-neuronal cell; Pattern; Pb element; Photoreceptors, Cone; Principal Investigator; Programs (PT); Programs [Publication Type]; Radiation, Laser; Research; Research Ethics Committees; Research Resources; Resources; Retina; Retina Proper; Retinal; Retinal Cone; Retinal Diseases; Retinal Disorder; Sapphire; Series; Shapes; Sight; Subcellular Process; Ti element; Time; Titanium; Vertebrate Animals; Vertebrates; Vision; Zebra Danio; Zebra Fish; Zebrafish; abstracting; cell motility; cone cell; daughter cell; expiration; heavy metal Pb; heavy metal lead; horizontal cell; human subject; image processing; imaging; in vivo; nerve cement; neurogenesis; neuronal; programs; retina disease; retina disorder; retinal neuron; retinopathy; time use; vertebrata",In vivo analysis of the developing vertebrate retina,,14358,BDPE,Biology and Diseases of the Posterior Eye Study Section,,9,347490,
7780354,R01,EY,5,,03/01/2010,02/28/2011,PA-07-070,5R01EY014411-08,,NEI:373973;,2010,NATIONAL EYE INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","POESCHLA, ERIC M.;",7678926;,5R01EY014411,04/01/2003,02/28/2012,"9alpha,11beta-PGF2; Adherence; Adherence (attribute); Agonist; Anabolism; Animal Model; Animal Models and Related Studies; Anterior Chamber; Anterior Chamber of the Eye; Anterior chamber of eye structure; Aqueous Humor; Assay; Bioassay; Biologic Assays; Biological Assay; Blindness; Body Tissues; COX-2 protein; COX2; COX2 enzyme; Cats; Crab-Eating Macaque; Cyclo-Oxygenase-2; Cyclooxygenase; Data; Dinoprost; Dinoprostone; Disease; Disorder; Domestic Cats; Drugs; Dysfunction; Eicosanoids; Elements; Engineering; Engineerings; Eye; Eye diseases; Eyeball; FP receptor; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Functional disorder; Funding; Gene Delivery; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene Transfer Techniques; Gene-Tx; Genes; Genetic Intervention; Glaucoma; Goals; Human; Human, General; Image; In Vitro; Intervention, Genetic; Intraocular Fluid; Intraocular Pressure; Investigators; Knowledge; Latanoprost; Learning; Lentiviral Vector; Lentivirus Vector; Leukotrienes; Life; Lipids; Macaca fascicularis; Mammals, Cats; Man (Taxonomy); Man, Modern; Medication; Messenger RNA; Mitotic; Modeling; Molecular Biology, Gene Therapy; Monkey, Crab-Eating; Monkey, Cynomolgus; Ocular Tension; PGD2 11-keto reductase; PGE2; PGE2 alpha; PGE2alpha; PGF receptor; PGF synthase; PGF synthetase; PGF2; PGF2 alpha; PGF2alpha; PGF2alpha synthase; PGH Synthase 2; PGHS-2; PGHS2; PHS II; POAG; PTGS2; Pathway interactions; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiologic Intraocular Pressure; Physiological; Physiology; Physiopathology; Primary Open Angle Glaucoma; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin F2; Prostaglandin F2 alpha; Prostaglandin F2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; RNA, Messenger; Receptor Protein; Research Personnel; Researchers; Role; Severities; Signaling Molecule; Structure; System; System, LOINC Axis 4; Testing; Therapy, DNA; Thromboxanes; Time; Tissues; Toxic effect; Toxicities; Trabecular Meshwork; Trabecular meshwork structure; Transgenes; Transgenesis; anterior chamber; aqueous; biosynthesis; cyclo-oxygenase II; cyclooxygenase 2; disability; disease/disorder; drug development; drug/agent; eye disorder; gene therapy; genetic therapy; glaucomatous; his-PG; imaging; imaging modality; in vivo; interest; mRNA; model organism; non-human primate; nonhuman primate; novel; ophthalmopathy; pathophysiology; pathway; prevent; preventing; progesterone 11-hemisuccinate-(2-iodohistamine); prostaglandin D2 11-keto reductase; prostaglandin D2-NADPH-dependent ketoreductase; prostaglandin F synthetase; prostaglandin H synthase-2; prostaglandin-F synthase; prostanoid FP receptor; public health relevance; receptor; response; social role; success; therapeutic transgene; tissue culture; vector",Eicosanoid Gene Therapy,,14411,AED,Anterior Eye Disease Study Section,,8,373973,
7741663,R01,EY,5,,12/01/2009,11/30/2010,PA-07-070,5R01EY015435-06,,NEI:559600;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"D'AMORE, PATRICIA ANN;",1898550;,5R01EY015435,05/01/2004,11/30/2013,"21+ years old; Abscission; Adult; Adverse effects; Age related macular degeneration; Angiogenesis, Pathologic; Angiogenesis, Pathological; Architecture; Assay; Atrophic AMD; Atrophic age-related macular degeneration; Autocrine Systems; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Blood Vessels; Blood flow; Body Tissues; Bruch Membrane; Bruch's basal membrane structure; CHIP assay; Cells; ChIP (chromatin immunoprecipitation); Choroid; Choroidal Neovascularization; Combining Site; Coupled; Development; Diffuse; Dry AMD; Electron Microscopy; Engineering; Engineering / Architecture; Engineerings; Excision; Extirpation; Eye; Eyeball; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Fundus photography; Genes; Genes, LacZ; Genetics-Mutagenesis; Human, Adult; Hypoxia; Hypoxic; Immunologic, Luciferase; In Vitro; Individual; Isoforms; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Knowledge; LacZ; LacZ Genes; Lamina Basalis Choroideae; Light; Luciferases; Maculopathy, Age-Related; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Mice, Transgenic; Modeling; Molecular; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Neovascularization, Choroid; Neovascularization, Pathological; Nervous; Nonexudative age-related macular degeneration; Organism; Outer pigmented layer of retina; Oxygen Deficiency; Pathogenesis; Pathologic; Pathologic Neovascularization; Pathology; Phenotype; Photoradiation; Physiologic; Physiological; Pigment Epithelium; Pigment cell layer of retina; Pigmented layer of retina; Play; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; RNA, Small Interfering; RPE65; RPE65 protein; Reactive Site; Regulation; Removal; Reporter; Retinal; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Role; Saints; Small Interfering RNA; Structure of Bruch's basal membrane; Structure of retinal pigment epithelium; Surgical Removal; Testing; Time; Tissues; Transgenic Mice; Treatment Side Effects; Up-Regulation; Up-Regulation (Physiology); Upregulation; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGFA; VEGFR-2; VEGFR2; VEGFs; Vascular Endothelial Growth Factor Gene; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vegf; Vegf gene; adult human (21+); age dependent; age related; autocrine; base; choroidal circulation; chromatin immunoprecipitation; eye fundus photography; geographic atrophy; in vivo; insight; living system; mouse model; neural; novel; public health relevance; relating to nervous system; resection; senile macular disease; siRNA; side effect; social role; therapy adverse effect; transcription factor; treatment adverse effect; vascular",Role of RPE-derived VEGF in Choroid Development and Stability," Narrative  Interactions between the retinal pigment epithelium and choroidal circulation are vital to normal retinal function and to pathologies such as age-related macular degeneration (AMD). Vascular endothelial growth factor (VEGF) is likely central to both. Understanding the role of VEGF in the maintenance of the choriocapillaris and the pigment epithelium is important to understanding the pathogenesis of AMD. In light of VEGF's role in vascular maintenance, current therapies aimed at VEGF neutralization in the eye for wet AMD may have unwanted side effects. Knowledge of the mechanisms of VEGF regulation in RPE under normal conditions may provide an opportunity to develop novel anti-VEGF therapies to inhibit the VEGF that mediates pathologic choroidal neovascularization, while sparing physiological VEGF expression.",15435,BDPE,Biology and Diseases of the Posterior Eye Study Section,,6,559600,
7743748,R01,EY,5,,01/01/2010,12/31/2010,PA-07-070,5R01EY016058-05,,NEI:376200;,2010,NATIONAL EYE INSTITUTE,,DETROIT,UNITED STATES,ANATOMY/CELL BIOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"HAZLETT, LINDA D;",1869132;,5R01EY016058,01/01/2005,12/31/2013,"Address; Antibodies; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; BALB/c; Bacteria; Bacteria resistance; Bacteria resistant; Bacterial resistant; Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; Blindness; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Blotting, Western; CASP-3; CASP3; COX-2 protein; COX2; COX2 enzyme; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chrysemonas; Clinical; Contact Lenses, Extended-Wear; Cornea; Corneal Diseases; Corneal Disorder; Cyclo-Oxygenase-2; Cyclooxygenase; Cysteine Protease CPP32; DNA; Data; Defensins; Deoxyribonucleic Acid; Development; Dinoprostone; Disease; Disease Outcome; Disorder; Endotoxins; Extended-Wear Contact Lenses; Eye; Eyeball; Figs; Figs - dietary; Flavimonas; Gene Products, RNA; Goals; Healed; Health; Heterophil Granulocyte; Histopathology; Human; Human, General; IL1 Receptors; Immune response; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Inbred BALB C Mice; Incidence; Infection; Inflammatory; Injection of therapeutic agent; Injections; Interleukin-1 Receptors; Intracellular Communication and Signaling; Keratitis; Killings; Leukocytes; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow leukocyte; Medical Economics; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Inbred BALB C; Molecular; Molecular and Cellular Biology; Mouse, BALB C; Murine; Mus; Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organism; P. aeruginosa; P.aeruginosa; PARP Cleavage Protease; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PTGS2; Pathogenesis; Patients; Perforation; Peroxidases; Phenotype; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Production; Programs (PT); Programs [Publication Type]; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Family; Pseudomonas; Pseudomonas aeruginosa; Pseudomonas pyocyanea; RNA; RNA, Messenger; RNA, Non-Polyadenylated; RT-PCR; RTPCR; Receptor Signaling; Receptors, IL-1; Receptors, Interleukin-1; Recombinant Proteins; Regulation; Reticuloendothelial System, Leukocytes; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic Acid; Role; SCA-1; SREBP Cleavage Activity 1; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staining method; Stainings; Stains; TLR protein; TLR4; TLR4 gene; TLR4 receptor; TOLL; Techniques; Testing; Time; Toll-4 receptor; Toll-like receptors; Treatment Cost; United States; VEGFs; Vascular Endothelial Growth Factors; Vegf; Vision research; Western Blotting; Western Blottings; Western Immunoblotting; White Blood Cells; White Cell; Yama; Yama protein; angiogenesis; antimicrobial peptide; bacterial resistance; biological signal transduction; caspase-3; clinical care; conventional therapy; cornea disorder; corneal; cyclo-oxygenase II; cyclooxygenase 2; cysteine protease P32; disease/disorder; early onset; economic impact; experiment; experimental research; experimental study; hToll; healing; host response; immunoresponse; inflammatory modulation; insight; living system; mRNA; member; microbial; neutrophil; novel; overgrowth bacterial; pathogen; prevent; preventing; pro-caspase-3; procaspase-3; programs; prostaglandin H synthase-2; protein blotting; public health relevance; research study; resistance to Bacteria; resistance to Bacterial; resistant to Bacteria; resistant to Bacterial; response; reverse transcriptase PCR; social role; toll-like receptor 4; white blood cell; white blood corpuscle",Role of Toll-Like Receptors in Bacterial Keratitis," Project Narrative P. aeruginosa is an opportunistic, gram-negative pathogen associated with bacterial keratitis, especially in extended wear contact lens users. Elucidating the precise role of TLR4 in microbial keratitis, including regulation of innate and adaptive immune responses, modulation of inflammatory angiogenesis, apoptosis and antimicrobial peptide production, will provide substantive insight into the pathogenesis of bacterial keratitis. Ultimately, the findings from this proposal will be useful clinically in development of better treatments to reduce bacterial keratitis and prevent blindness.",16058,AED,Anterior Eye Disease Study Section,,5,376200,
7758300,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY016400-05,,NEI:367694;,2010,NATIONAL EYE INSTITUTE,,ATLANTA,UNITED STATES,BIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"YOKOYAMA, SHOZO ;",1891756;,5R01EY016400,02/01/2006,01/31/2011,"Absorption; Amino Acid Substitution; Amino Acids; Bayesian Method; Binding; Binding (Molecular Function); Biological Models; Bioluminescence; Bovine Species; Cattle; Charge; Chemicals; Chemistry; Chimera; Chimera organism; Color Visions; Computing Methodologies; DNA; Deoxyribonucleic Acid; Electrostatics; Engineering; Engineerings; Environment; Evolution; Fishes; Genes; Genetic; Globin; Goals; Habitats; Hybrids; Individual; Investigators; Ions; Life; Light; Method, Bayesian; Methods; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Nature; Nucleotides; Opsin; Organism; Pattern; Photoradiation; Phototransduction; Phylogenetic Analysis; Phylogenetics; Pigments; Polyenes; Process of absorption; Programs (PT); Programs [Publication Type]; Proteins; Research; Research Personnel; Researchers; Retinal; Retinal Pigments; Rhodopsin; Rod-Opsin; Schiff Bases; Science of Chemistry; Science of Statistics; Sea; Series; Sight; Signal Transduction, Light; Site; Statistical Methods; Statistics; Structure; Sunlight; Testing; Time; Trees; Vertebrate Animals; Vertebrates; Vision; Visions, Color; Visual Pigments; Visual Purple; Visual Transduction; absorption; aminoacid; base; bovid; bovine; comparative; computational methodology; computational methods; computer methods; cow; gene product; living system; migration; new approaches; novel approaches; novel strategies; novel strategy; p-Globin; pi bond; programs; retina photosensitive pigment; statistics; vertebrata",Adaptive Evolution of Color Vision,,16400,GVE,Genetic Variation and Evolution Study Section,,5,367694,
7761666,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY016462-05,,NEI:466103;,2010,NATIONAL EYE INSTITUTE,,AUSTIN,UNITED STATES,BIOMEDICAL ENGINEERING,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"RYLANDER, HENRY GRADY;",6138940;,5R01EY016462,03/01/2006,01/31/2011,"Aneurysm; Apoptosis; Apoptosis Pathway; Apoptotic; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Axon; Basic Research; Basic Science; Biomedical Engineering; Birefraction; Birefringence; Birefringences; Body Tissues; Cardiology; Cardiovascular Disease (Specialty); Cartilage; Cartilagenous Tissue; Cell Death, Programmed; Cellular Stress; Cessation of life; Clinical; Clinical Research; Clinical Study; Common Rat Strains; Cornea; Death; Dentistry; Dermatology; Diagnosis; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Discipline; Doctor of Medicine; Doppler OCT; Double Refraction; Electromagnetic, Laser; Electron Microscope; Eye; Eyeball; Fiber; Ganglion Cells (Retina); Glaucoma; Goals; Health Sciences; Histology; Human; Human, General; Image; Imaging technology; Institutes; Invertebrata; Invertebrates; Invertebrates, General; Investigation; Investigators; Laboratories; Lasers; M.D.; Macromolecular Structure; Mammals, Primates; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Structure; Monitor; Monitoring, Patient; Muscle; Muscle Tissue; Nerve; Nervous; Neurology; OCT Tomography; Ophthalmology; Optical Coherence Tomography; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Pathologic; Patient Monitoring; Primates; Principal Investigator; Programs (PT); Programs [Publication Type]; Radiation, Laser; Rat; Rattus; Research; Research Personnel; Researchers; Resolution; Retinal Ganglion Cells; Rheumatology; Scanning; Sensitivity and Specificity; Signal Pathway; Skin; Streaks, Arterial Fatty; Techniques; Tendon structure; Tendons; Testing; Texas; Thick; Thickness; Tissues; Tomography, Optical Coherence; Transmission; Universities; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; austin; axonal degeneration; base; bioengineering; bioengineering/biomedical engineering; case control; clinical applicability; clinical application; corneal; density; experiment; experimental research; experimental study; glaucomatous; imaging; instrument; polarimetry; programs; research study; retinal ganglion; retinal nerve fiber layer; tissue phantom; transmission process; vulnerable plaque",Quantitative RNFL Assessment for Glaucoma Diagnosis,,16462,ZRG1,Special Emphasis Panel,,5,466103,
7755351,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY016607-19,,NEI:410941;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,NEUROSCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SMITH, ROBERT G;",1897423;,5R01EY016607,09/30/1991,01/31/2011,"Amacrine Cells; Amacrine Cells of Retina; Benchmarking; Best Practice Analysis; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Clinical; Code; Coding System; Communicating Junction; Complex; Computer Programs and Programming; Computer Simulation; Computerized Models; Cone; Cones (Eye); Cones (Retina); Coupling; Data Set; Dataset; Dendrites; Detection; Electrodes; Elements; Encephalon; Encephalons; Environment; Event; Eye; Eye diseases; Eyeball; Frequencies (time pattern); Frequency; Gap Junctions; Gray; Gray unit of radiation dose; Intracellular Communication and Signaling; Investigators; Ion Channels, Potassium; K channel; Knowledge; Life; Low-resistance Junction; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Methods; Modeling; Models, Computer; Morphology; Motion; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nexus; Nexus Junction; Night Blindness; Noise; Nyctalopia; Pathway interactions; Performance; Photoreceptors, Cone; Potassium Channel; Process; Property; Property, LOINC Axis 2; Research Personnel; Researchers; Retina; Retinal; Retinal Cone; Retinal Dystrophy; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Stimulus; Sum; Synapses; Synaptic; Testing; Time; Transmission; Trees; V (voltage); VESCL; Vesicle; Visual; Visual Pathways; Work; biological signal transduction; computational modeling; computational models; computational simulation; computer based models; computer program; computer programming; computerized data processing; computerized modeling; computerized simulation; cone cell; data processing; detector; eye disorder; gangliocyte; ganglion cell; improved; in silico; neural; neural circuit; neural circuitry; neuronal; ophthalmopathy; paired stimuli; pathway; postsynaptic; presynaptic; receptive field; relating to nervous system; response; rod cell; signal processing; theories; transmission process; virtual simulation; visual coding; visual performance; voltage; voltage gated channel",Retinal circuits for precise coding,,16607,BDPE,Biology and Diseases of the Posterior Eye Study Section,,19,410941,
7761667,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY016715-04,,NEI:329419;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"DRAGOI, VALENTIN ;",8139351;,5R01EY016715,02/01/2007,01/31/2011,"Area striata; Area striata structure; Behavioral; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Cerebral cortex; Code; Coding System; Cognitive Discrimination; Complex; Cortex, Striate; Discrimination; Discrimination (Psychology); Electrodes; Encephalon; Encephalons; Environment; Eye; Eyeball; Human; Human, General; Image; Individual; Intracellular Communication and Signaling; Learning; Link; Man (Taxonomy); Man, Modern; Measures; Methods and Techniques; Methods, Other; Monkeys; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Noise; Performance; Population; Preparedness; Primary visual cortex; Process; Prosthesis; Prosthetic device; Prosthetics; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Readiness; Research; Retina; Sensory Process; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stimulus; Striate area; Structure; Techniques; Time; V1 neuron; Variant; Variation; Visual; Visual Cortex; Visual Perception; Visual System; Visual system structure; Visually Impaired Persons; area striata; base; biological signal transduction; blind individual; blind people; blind person; experiment; experimental research; experimental study; extrastriate visual cortex; imaging; improved; information processing; neuronal; orientation preference; orientation selectivity; psycho-physiological; research study; response; stimulus processing; visual cortical; visually impaired people",Dynamic coding of image features in primary visual cortex,,16715,CVP,Central Visual Processing Study Section,,4,329419,
7758302,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY016716-04,,NEI:355163;,2010,NATIONAL EYE INSTITUTE,,WINSTON-SALEM,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"STEIN, BARRY E;",1866044;,5R01EY016716,02/01/2007,01/31/2012,"Affect; Anterior; Anterior Quadrigeminal Body; Attention; Behavior; Behavioral; Belief; Binding; Binding (Molecular Function); Biological Models; Bone structure of ilium; Brain; Brain region; Cats; Causality; Clinic; Conflict; Conflict (Psychology); Corpora quadrigemina, superior colliculus; Cues; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Domestic Cats; Employee Strikes; Encephalon; Encephalons; Etiology; Evaluation; Event; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Foundations; History; Human; Human, General; Ilium; Individual; Mammals, Cats; Man (Taxonomy); Man, Modern; Mesencephalon; Mid-brain; Midbrain; Midbrain structure; Model System; Modeling; Models, Biologic; Molecular Interaction; Motivation; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Optic Tectum; Patients; Perception; Performance; Physical Health Services / Rehabilitation; Physiologic; Physiological; Plant Roots; Population; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Recording of previous events; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Rest; Role; Seminal; Sensory; Sensory Neglects; Source; Specificity; Stimulus; Strikes; Strikes, Employee; Sum; Superior Colliculus; Surgical; Surgical Interventions; Surgical Procedure; Syndrome; Tectums, Optic; Testing; Touch; Touch sensation; Training; Translating; Translatings; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Visual; auditory stimulus; base; clinical data repository; clinical data warehouse; data repository; design; designing; developmental disease/disorder; developmental disorder; disease causation; disease etiology; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; extrastriate visual cortex; gaze; ilium; insight; language translation; multisensory; neglect; neural; neuronal; programs; rehabilitative; relating to nervous system; relational database; research study; response; root; sensory cortex; sensory system; social role; spatial integration; superior colliculus Corpora quadrigemina; surgery; traumatic brain damage; visual motor; visual process; visual processing; visual stimulus; visual tectum; visuomotor",Processing Visual and Multisensory Information,,16716,COG,Cognitive Neuroscience Study Section,,4,355163,
7756613,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY017137-05,,NEI:300154;,2010,NATIONAL EYE INSTITUTE,,PROVIDENCE,UNITED STATES,NEUROSCIENCES,01,001785542,US,RI,02912,BROWN UNIVERSITY,"BERSON, DAVID M.;",1902571;,5R01EY017137,02/01/2006,01/31/2011,"Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Acute; Affect; Amacrine Cells; Amacrine Cells of Retina; Behavior; Behavioral; Biology; Brain; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Circadian Rhythms; Cone; Cones (Eye); Cones (Retina); Dark Adaptation; Data; Dendrites; Dependency; Dependency (Psychology); Diurnal Rhythm; Encephalon; Encephalons; Exhibits; Ganglion Cells (Retina); History; Hypothalamic structure; Hypothalamus; Illumination; Image; In element; Indium; Intracellular Communication and Signaling; Investigation; Investigators; Kinetic; Kinetics; Laboratories; Light; Lighting; Mediating; Melatonin; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nucleus; Nyctohemeral Rhythm; Opsin; Output; Pace Stimulators; Pacemakers; Pattern; Phase; Photic Stimulation; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Phototransduction; Physiologic; Physiological; Physiology; Process; Programs (PT); Programs [Publication Type]; Pupil light reflex; Recording of previous events; Reflex; Reflex action; Regulation; Research; Research Personnel; Researchers; Retina; Retinal; Retinal Cone; Retinal Ganglion Cells; Rod-Opsin; Rods and Cones; Role; Scotopic Adaptation; Sight; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Sleep; Stimulators, Electrical, Pace; Structure; Structure of suprachiasmatic nucleus; Suprachiasmatic Nucleus; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Time; Twenty-Four Hour Rhythm; Vertebrate Photoreceptors; Vision; Visual; Visual Receptor; Visual Stimulation; Visual Transduction; alertness; biological signal transduction; circadian; circadian clock; circadian pacemaker; circadian process; cone cell; daily biorhythm; diurnal variation; emotional dependency; gangliocyte; ganglion cell; hypothalamic; imaging; melanopsin; neuronal; novel; programs; pupillary light reflex; pupillary reflex; response; retinal ganglion; retinal neuron; social role; suprachiasmatic nucleus",Biology of Photosensitive Ganglion Cells,,17137,ZRG1,Special Emphasis Panel,,5,300154,
7760082,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY017198-04,,NEI:310860;,2010,NATIONAL EYE INSTITUTE,,DALLAS,UNITED STATES,OPHTHALMOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"CHEN, PETER W;",1942429;,5R01EY017198,02/01/2007,01/31/2012,"Address; Anterior; Anterior Chamber; Anterior Chamber of the Eye; Anterior chamber of eye structure; Antigen Presentation; Apoptosis Antigen Ligand 1; Aqueous Humor; Assay; Autoantigens; Autologous Antigens; Bioassay; Biologic Assays; Biological Assay; Blood; Blotting, Western; Body Tissues; Bone-Derived Transforming Growth Factor; CD178 Antigen; CD95 Ligand; CD95 antigen ligand; CHIP assay; Cells; ChIP (chromatin immunoprecipitation); Chemical Fractionation; Cornea; Corneal Transplantation; DNA Methylation; Data; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drainage; Drainage procedure; EC 2.1.1; Embryonic Tissue, Placenta; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Exposure to; Eye; Eye Neoplasms; Eyeball; FRACN; Fas Ligand; Fas ligand (FasL); Fas-L; FasL protein; Forecast of outcome; Fractionation; Fractionation Radiotherapy; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Grafting, Corneal; Histocompatibility; INFLM; Immune; Immune response; Immunosuppressants; Immunosuppressive Agents; Individual; Inflammation; Inflammatory; Intraocular Fluid; Keratoplasty; Lymphatic; Mass Spectrum; Mass Spectrum Analysis; Melanocortin-1; Methods; Methods and Techniques; Methods, Other; Methylation; Methyltransferase; Milk Growth Factor; Molecular; Molecular Weight; Neuropeptides; Ocular Neoplasm; Ocular Tumor; Patients; Photometry/Spectrum Analysis, Mass; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Platelet Transforming Growth Factor; Play; Production; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Proteins; Proteome; R01 Mechanism; R01 Program; RNA Expression; RPG; Regulation; Reporter; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Reticuloendothelial System, Blood; Risk; Role; Self-Antigens; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; TGF B; TGF-beta; TGFbeta; Techniques; Testing; Time; Tissue Compatibility; Tissues; Transcription; Transcription, Genetic; Transforming Growth Factor beta; Transplantation; Transplantation, Cornea; Tumor Necrosis Factor Ligand Superfamily Member 6; Tumor of the Eye; Up-Regulation; Up-Regulation (Physiology); Upregulation; Western Blotting; Western Blottings; Western Immunoblotting; alpha-MSH; alpha-Melanocyte stimulating hormone; alpha-Melanotropin; alpha-Melanotropin (pig); anterior chamber; base; chromatin immunoprecipitation; chromatin remodeling; corneal; corneal keratoplasty; corneal transplant; cytokine; gene product; high risk; histocompatibility gene; host response; immune clearance; immunogenicity; immunoresponse; immunosuppressive; improved; methylase; outcome forecast; pathogen; prevent; preventing; protein blotting; social role; success; transmethylase; transplant; trophoblast; tumor; vector",Epigenetic Gene Regulation by the Ocular Environment,,17198,AED,Anterior Eye Disease Study Section,,4,310860,
7760876,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY017381-04,,NEI:435290;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"GILMORE, MICHAEL S.;",8143601;,5R01EY017381,02/01/2007,01/31/2012,"Adherence; Adherence (attribute); Adhesins, Bacterial; Affect; Area; Artifacts; Bacteria; Bacterial Adhesins; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Biological Models; Blinking; Body Tissues; Cell Line, Transformed; Cell surface; Cells; Cellular biology; Cold-Insoluble Globulins; Combining Site; Community-Acquired Infections; Complication; Contact Lenses; Contact Lenses, Extended-Wear; Cornea; Corneal Injury; Deposit; Deposition; Drugs; Effectiveness; Environment; Epithelial Cells; Epithelium, Anterior Corneal; Epithelium, Corneal; Equilibrium; Event; Extended-Wear Contact Lenses; Extracellular Matrix Proteins; Eye; Eyeball; FN1; FNZ; Fibronectin 1; Fibronectins; Friction; Future; Genes; Glycopeptides; Goals; HOSP; Harvest; Healed; Hospital Infections; Hospital acquired infection; Hospitals; Human; Human, General; Hypoxia; Hypoxic; Immune response; Infection; Investigators; Keratitis; LETS Proteins; Laboratories; Large External Transformation-Sensitive Protein; Lead; Ligand Binding Protein; Ligands; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mechanics; Medication; Membrane Proteins; Membrane-Associated Proteins; Methicillin Resistance; Mice; Microbe; Microbial Biofilms; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Morphologic artifacts; Mucins; Mucus Glycoprotein; Murine; Mus; Nosocomial Infections; O element; O2 element; Operation; Operative Procedures; Operative Surgical Procedures; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Oxygen; Oxygen Deficiency; P. aeruginosa; P.aeruginosa; Parasites; Pathogenesis; Pathology; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phylogenetic Analysis; Phylogenetics; Polymorphism, Single Base; Position; Positioning Attribute; Predisposition; Pressure; Pressure- physical agent; Production; Programs (PT); Programs [Publication Type]; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Public Health; Reactive Site; Receptor Protein; Research; Research Personnel; Researchers; Resistance; Risk; Risk Factors; Role; S. aureus; S.aureus; SNP; SNPs; Services; Single Nucleotide Polymorphism; Site; Staphylococcus aureus; Structure of corneal epithelium; Surface Proteins; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; System; System, LOINC Axis 4; Telomerase; Testing; Time; Tissues; Toxin; Transformed Cell Line; Trauma; VRSA; Vancomycin; Vancomycin-resistant S. aureus; Vancomycin-resistant S.aureus; Vancomycin-resistant Staphylococcus aureus; adhesin; alpha 2-Surface Binding Glycoprotein; balance; balance function; base; biofilm; cell biology; corneal; corneal epithelial; corneal epithelium; corneal wound; cytokine; design; designing; drug/agent; experiment; experimental research; experimental study; eye blink; eyeblink; healing; heavy metal Pb; heavy metal lead; host response; human tissue; immunoresponse; inhibitor; inhibitor/antagonist; institutional infection; lens; methicillin resistant; microbial; mutant; novel; ocular surface; pathogen; pressure; programs; public health medicine (field); receptor; reconstitute; reconstitution; research study; resistant; response; social role; stem; surgery; trait; wound",Adherence and Colonization in Keratitis,,17381,AED,Anterior Eye Disease Study Section,,4,435290,
7758303,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY017577-03,,NEI:285451;,2010,NATIONAL EYE INSTITUTE,,BALTIMORE,UNITED STATES,OPHTHALMOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"NGUYEN, QUAN DONG;",6297186;,5R01EY017577,02/01/2008,01/31/2011,"Address; Administrator; Age; Algorithms; Animal Welfare; Applications Grants; Area; Bibliography; Blindness; Blood; Blood capillaries; Blood flow; Body Tissues; Budgets; Calibration; Capillaries; Capillary; Capillary, Unspecified; Clinical; Cognitive Discrimination; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communication; Country; Critiques; Data; Development; Device or Instrument Development; Devices; Diabetes Mellitus; Diabetic Retinopathy; Discrimination; Discrimination (Psychology); Disease; Disorder; Doppler OCT; Dropsy; Early Diagnosis; Early treatment; Ecological impact; Edema; Editorial Comment; Editorial Comment (PT); Electromagnetic, Laser; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Eye; Eye diseases; Eyeball; Fluorescein Angiography; Fundus; Fundus photography; Generations; Goals; Grant Proposals; Grants, Applications; Health Sciences; Hearing; Hemoglobin; Human Resources; Hydrops; IACUC; IRBs; Illumination; Image; Impact, Environmental; In Vitro; Individual; Institutes; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Investigators; Lasers; Lighting; Manpower; Maps; Measurement; Measures; Methodology, Research; Methods; Methods and Techniques; Methods, Other; O element; O2 element; OCT Tomography; Ophthalmology; Optical Coherence Tomography; Oregon; Oxygen; Partial Sight; Patients; Phase; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Pigmentation; Pigmentation physiologic function; Pilot Projects; Population; Position; Positioning Attribute; Prevention strategy; Preventive strategy; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; R01 Mechanism; R01 Program; RPG; Radiation, Laser; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Grants; Research Methodology; Research Methods; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Research Resources; Researchers; Resolution; Resources; Reticuloendothelial System, Blood; Retina; Retinal; Retinal Diseases; Retinal Disorder; Series; Solutions; Speed; Speed (motion); Structure; Study Section; Study Type; Suggestion; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Thick; Thickness; Tissues; Tomography, Optical Coherence; Universities; Validation; Variant; Variation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual Receptor; Visual impairment; Work; abstracting; capillary; device development; diabetes; diabetic; diabetic patient; disease/disorder; early detection; expiration; eye disorder; eye fundus photography; hearing perception; human subject; imaging; in vivo; instrument development; interventional strategy; macular edema; novel; ophthalmopathy; personnel; pilot study; prevent; preventing; programs; recruit; retina disease; retina disorder; retina ischemia; retinal ischemia; retinopathy; simulation; sound perception; study design; tool; vertebrata; visually impaired",Novel Assessment of Early Changes in Diabetic Retinopathy,,17577,ZRG1,Special Emphasis Panel,,3,285451,
7751235,R01,EY,5,,12/01/2009,11/30/2010,PA-07-070,5R01EY017641-03,,NEI:484069;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"CHEN, DONG FENG;",6197462;,5R01EY017641,12/01/2007,11/30/2010,"21+ years old; Adult; Age; Animal Welfare; Area; Astrocytes; Astrocytus; Astroglia; Axon; Axotomy; Bibliography; Brain; Cell Communication and Signaling; Cell Signaling; Cellular biology; Cicatrix; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Cranial Nerve II; Cranial Nerve II Diseases; Cranial Nerve II Disorder; Critiques; Data; Development; Disease; Disorder; Disorder of the optic nerve; Ecological impact; Editorial Comment; Editorial Comment (PT); Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; FLR; Failure (biologic function); Ganglion Cells (Retina); Glaucoma; Goals; Human; Human, Adult; Human, General; IACUC; IRBs; Impact, Environmental; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Ipsilateral; Light; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods; Mice; Modeling; Murine; Mus; Myelin; Natural regeneration; Nerve; Nervous; Nervous System, Brain; Neural-Optical Lesion; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurologic; Neurological; Optic Nerve; Optic Nerve Diseases; Optic Neuropathy; Outcome; Photoradiation; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; Regeneration; Research; Research Ethics Committees; Research Resources; Resources; Retinal Degeneration; Retinal Ganglion Cells; Scars; Second Cranial Nerve; Second Cranial Nerve Diseases; Side; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Suggestion; Testing; Time; Trauma; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Vision; Visual; abstracting; adult animal; adult human (21+); axon regeneration; axonal regeneration; behavior test; behavioral test; biological signal transduction; cell biology; disease/disorder; experiment; experimental research; experimental study; expiration; failure; functional restoration; genetic technology; glaucomatous; human subject; improved; mature animal; optic nerve disorder; optic nerve regeneration; postnatal; programs; regenerate; research study; response; restore function; restore functionality; restore lost function; retina degeneration; retinal degenerative; retinal ganglion; second cranial nerve disorder; synapse formation; synaptogenesis; vertebrata",Functional Restoration of the Optic Nerve After Disease or Damage,,17641,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,3,484069,
7762225,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY017678-03,,NEI:303930;,2010,NATIONAL EYE INSTITUTE,,BERKELEY,UNITED STATES,NONE,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"SCHOR, CLIFTON M;",1867566;,5R01EY017678,02/01/2008,01/31/2013,"Acceleration; Address; Affect; Age; Aged 65 and Over; Aging; Animal Welfare; Bibliography; Biomechanics; Brain; Calibration; Categories; Cell Communication and Signaling; Cell Signaling; Childhood; Clinical Trials; Clinical Trials, Unspecified; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Compensation; Conflict; Conflict (Psychology); Country; Coupled; Crystalline Lens; Data; Development; Ecological impact; Editorial Comment; Editorial Comment (PT); Elderly; Elderly, over 65; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Eye; Eyeball; Eyeglasses; Financial compensation; Human; Human, General; IACUC; IRBs; Impact, Environmental; Implant; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Intraocular lens implant device; Investigation; Knowledge; Lead; Len, Crystalline; Len, Eye; Lens; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Lenses, Intraocular; Life; Man (Taxonomy); Man, Modern; Measures; Modeling; Nervous; Nervous System, Brain; Ocular Lens; Optics; Pb element; Phase; Plants; Plants, General; Position; Positioning Attribute; Presbyopia; Presbyopias; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Published Comment; Refractive Disorders; Refractive Errors; Research; Research Ethics Committees; Research Resources; Resources; Running; Sampling; Senescence; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Spectacles; Staging; Stimulus; Structure; Testing; Time; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viscosity; abstracting; advanced age; age dependent; age effect; age related; aging effect; biological signal transduction; clinical investigation; cross-link; crosslink; design; designing; elders; experiment; experimental research; experimental study; expiration; eye refraction disorder; falls; geriatric; heavy metal Pb; heavy metal lead; human subject; innervation; late life; later life; lens; motor control; nerve supply; neural; neural control; neural regulation; neuroregulation; older adult; older person; pediatric; programs; relating to nervous system; research study; response; senescent; senior citizen; trend; vertebrata; visual motor; visuomotor",Sensory-Motor Control of the Binocular Near Response,,17678,CVP,Central Visual Processing Study Section,,3,303930,
7761663,R01,EY,5,,02/01/2010,01/31/2011,,5R01EY017916-04,,NEI:337141;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"DESPLAN, CLAUDE ;",2456904;,5R01EY017916,02/01/2007,01/31/2012,"Address; Affect; Anatomic; Anatomical Sciences; Anatomy; Behavioral Genetics; Biological Neural Networks; Brain; Cell Body; Cell Communication and Signaling; Cell Signaling; Cells; Clone Cells; Cognitive Discrimination; Color; Color Visions; Complement; Complement Proteins; Connector Neuron; Corpora Bigemina; Development; Discrimination; Discrimination (Psychology); Drosophila; Drosophila genus; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Event; Fruit Fly, Drosophila; Future; Genes; Genetic Determinants of Behavior; Genetics, Behavioral; Image; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Knowledge; Light; Logic; Maps; Mediating; Morphology; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Neurotransmitters; Optic Lobe; Output; Pattern; Photoradiation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Play; Process; Reporter; Retina; Rhodopsin; Role; Science of Anatomy; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Time; Transgenic Organisms; UV sensitive; UV sensitivity; Visions, Color; Visual Purple; Visual Receptor; Visual System; Visual system structure; Work; anatomy; base; behavior genetics; behavior test; behavioral test; biological signal transduction; cell body (neuron); cell type; color detection; color processing; experiment; experimental research; experimental study; fruit fly; gain of function; gene function; imaging; information processing; innervation; migration; molecular marker; nerve supply; neural cell body; neural mechanism; neural network; neuroblast; neuromechanism; neuronal; neuronal cell body; research study; social role; soma; tool; transcription factor; transgenic",Mapping the optic lobes for color vision,,17916,NCF,Neurogenesis and Cell Fate Study Section,,4,337141,
7744634,R01,EY,5,,01/01/2010,12/31/2010,PAR-07-144,5R01EY018000-02,,NEI:339442;,2010,NATIONAL EYE INSTITUTE,,CHARLOTTESVILLE,UNITED STATES,BIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"GRAINGER, ROBERT M;",1866564;,5R01EY018000,01/01/2009,12/31/2012,"Address; Affect; Animal Model; Animal Models and Related Studies; Assay; Binding Sites; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Models; Biological Process; Body Tissues; Categories; Code; Coding System; Collaborations; Combining Site; Communities; Complement; Complement Proteins; Complex; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Developmental Cell Biology; Developmental Process; Distant; ES cell; Elements; Embryo; Embryonic; Embryonic Eye; Engineering; Engineerings; Enhancer Elements; Enhancer Elements (Genetics); Enhancers; Eye; Eyeball; Frog; Functional RNA; Future; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transfer Techniques; Genes; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetic screening method; Genetics, Human; Genome; Genomics; Goals; Hereditary Disease; Human; Human Genetics; Human, General; In element; Indium; Individual; Laboratories; Lead; Lesion; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Model System; Models, Biologic; Molecular Disease; Murine; Mus; Mutant Strains Mice; Mutate; Mutation; Non-Coding; Non-Coding RNA; Nucleic Acid Regulatory Sequences; Organogenesis; Patients; Pattern; Pb element; Phenotype; Procedures; Process; Programs (PT); Programs [Publication Type]; Rana; Rana (genus); Reactive Site; Regulator Genes; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Reporter; Research; Research Resources; Resources; Role; Site; Study Subject; Survey Instrument; Surveys; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Targetings, Gene; Techniques; Technology; Testing; Tissues; Transcriptional Regulatory Elements; Transgenesis; Transgenic Animals; Transgenic Organisms; Vertebrate Animals; Vertebrates; Work; Xenopus; clinical data repository; clinical data warehouse; comparative; comparative genomics; data repository; disease phenotype; embryonic stem cell; eye formation; gene function; genetic disorder; genetic enhancer element; genetic regulatory element; genetic testing; genome mutation; genome sequencing; genome, vertebrate; heavy metal Pb; heavy metal lead; hereditary disorder; high throughput analysis; human disease; insight; markov model; model organism; mouse mutant; mutant; novel; null mutation; programs; public health relevance; regulatory gene; relational database; slug; social role; stem cell of embryonic origin; trans acting element; transgenic; vertebrata; vertebrate genome",Genomic survey of cis-regulatory element function by high-throughput transgenesis,,18000,ZRG1,Special Emphasis Panel,,2,339442,
7761660,R01,EY,5,,02/01/2010,01/31/2011,PAR-06-410,5R01EY018068-03,,NEI:415800;,2010,NATIONAL EYE INSTITUTE,,COLD SPRING HARBOR,UNITED STATES,,03,065968786,US,NY,11724,COLD SPRING HARBOR LABORATORY,"KOULAKOV, ALEXEI ;",8573448;,5R01EY018068,02/01/2008,01/31/2012,"Address; Anterior Quadrigeminal Body; Axon; Biological Neural Networks; Brain; Cells; Child Development Disorders; Collaborations; Computer Software Tools; Corpora quadrigemina, superior colliculus; Data; Defect; Degenerative Disorder; Dendrites; Development; Developmental Disabilities; EPH; Encephalon; Encephalons; Eph Family Receptors; Eph Receptor Ligands; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Ephrins; Genetic Algorithm; Genetic Programming; Goals; Human; Human, General; Imagery; Impairment; Internet; Label; Ligands; Link; Man (Taxonomy); Man, Modern; Maps; Mice, Mutant Strains; Modeling; Molecular; Mutant Strains Mice; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Optic Tectum; Pathway interactions; Procedures; Publications; Receptors, Eph Family; Receptors, N-Methylaspartate; Research Resources; Resources; Retina; Retinal; Role; Rotation; Scientific Publication; Sensory; Shapes; Software Tools; Staging; Superior Colliculus; Surgical; Surgical Interventions; Surgical Procedure; Synapses; Synaptic; Tectum Mesencephali; Tectums, Optic; Testing; Time; Tools, Software; VESCL; Vertebrate Animals; Vertebrates; Vesicle; Visual; Visualization; WWW; base; degenerative condition; degenerative disease; design; designing; develop software; developing computer software; genetic manipulation; insight; model development; mouse mutant; neural; neural network; neuronal; pathway; relating to nervous system; retino-tectal; retinotectal; retinotopic; simulation; social role; software development; superior colliculus Corpora quadrigemina; surgery; vertebrata; visual process; visual processing; visual tectum; web; world wide web",Quantitiative model for the development of neural topographic maps,,18068,ZRG1,Special Emphasis Panel,,3,415800,
7761659,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018119-03,,NEI:418275;,2010,NATIONAL EYE INSTITUTE,,NEW YORK,UNITED STATES,BIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"GILBERT, CHARLES D;",1887402;,5R01EY018119,02/01/2008,01/31/2013,"21+ years old; Acute; Address; Adeno-Associated Viruses; Adult; Anesthesia; Anesthesia procedures; Animal Welfare; Animals; Area; Area striata; Area striata structure; Associated Viruses; Autopsy; Axon; Back; Bibliography; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Computer Simulation; Computerized Models; Cortex, Striate; Country; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dendrites; Dependovirus; Dorsum; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Experimental Designs; Experimental Models; Experimental Models, Other; Feedback; GFP; Genes; Global Change; Green Fluorescent Proteins; Human, Adult; IACUC; IRBs; Image; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Label; Learning; Lesion; Life; Macular degeneration; Macular degenerative disease; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mediating; Microscopy; Modeling; Models, Computer; Models, Experimental; Monitor; Monkeys; Morphology; Nature; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Perceptual learning; Photons; Play; Position; Positioning Attribute; Preparation; Prevalence; Primary visual cortex; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Recovery; Recovery of Function; Recruitment Activity; Relative; Relative (related person); Research; Research Ethics Committees; Research Resources; Resources; Retina; Retinal; Retinal Degeneration; Role; Satellite Viruses; Scotoma; Series; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Striate area; Suggestion; Testing; Time; V1 neuron; Vertebrate Animals; Vertebrates; Virus; Viruses, General; Visual Cortex; Visual Field Disorder; Visual Pathways; Visual field scotoma; Work; abstracting; adeno associated virus group; adult human (21+); area striata; awake; biological signal transduction; cell imaging; cellular imaging; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; critical period; design; designing; developmental plasticity; experience; experiment; experimental research; experimental study; expiration; fluorophore; functional recovery; human subject; imaging; improved; in silico; in vivo; necropsy; neurodegenerative illness; neuronal; postmortem; postnatal; programs; receptive field; recruit; research study; response; retina degeneration; retinal damage; retinal degenerative; social role; vertebrata; virtual simulation; visual cortical; visual field defect",Adult visual cortical plasticity,,18119,CVP,Central Visual Processing Study Section,,3,418275,
7768404,R01,EY,5,,03/01/2010,02/28/2011,,5R01EY018132-04,,NEI:367850;,2010,NATIONAL EYE INSTITUTE,,ANN ARBOR,UNITED STATES,BIOCHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"GOLDMAN, DANIEL J;",1891130;,5R01EY018132,04/01/2007,02/28/2011,"Active Follow-up; Applications Grants; Biological; Biological Models; Blindness; Brachydanio rerio; Cells; DNA Recombination; DNA recombination (naturally occurring); Danio rerio; Fishes; Foundations; Future; Gene Expression; Genes; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Genome; Glia; Glial Cells; Goals; Grant Proposals; Grants, Applications; Injury; Investigation; Kolliker's reticulum; Label; Lead; Life; Mammalia; Mammals; Mammals, General; Maps; Mediating; Model System; Models, Biologic; Molecular; Multipotent Stem Cells; Mutation; Natural regeneration; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Pb element; Play; Population; Process; Proliferating; Recombination; Recombination, Genetic; Regeneration; Research; Retina; Retinal; Retinal Degeneration; Role; Sight; Signaling Molecule; Source; System; System, LOINC Axis 4; Testing; Tubulin; Vision; Western World; Zebra Danio; Zebra Fish; Zebrafish; cell type; experiment; experimental research; experimental study; follow-up; genome mutation; heavy metal Pb; heavy metal lead; improved; injured; multipotent progenitor; nerve cement; neuronal; progenitor; regenerate; regenerative; repair; repaired; research study; response; retina degeneration; retinal degenerative; retinal neuron; retinal regeneration; social role; stem cell population; transcription factor",Muller glia and retina regeneration,,18132,BDPE,Biology and Diseases of the Posterior Eye Study Section,,4,367850,
7755352,R01,EY,5,,01/01/2010,12/31/2010,PA-07-070,5R01EY018171-03,,NEI:378675;,2010,NATIONAL EYE INSTITUTE,,IRVINE,UNITED STATES,OPHTHALMOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"WECHSLER, STEVEN L;",1891979;,5R01EY018171,01/01/2008,12/31/2010,"Address; Animal Welfare; Anterior; Apoptosis; Apoptosis Pathway; Assay; B220; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blindness; CD45; CD8; CD8B; CD8B1; CD8B1 gene; Caliber; Cell Death, Programmed; Cells; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Confocal Microscopy; Cornea; Country; Data; Developed Countries; Developed Nations; Diameter; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Epithelial; Epithelium; Equipment; Ethics Committees, Research; Eye; Eyeball; Fluorescein; Fluoresceins; Fluorescence; GP180; Gasser's Ganglion; Gasserian Ganglion; Grant; HHV-1; HSV; HSV-1; HSV1; Healed; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus hominis; Human; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; Human, General; IACUC; IRBs; Image; Immune; Immune response; Immunity; Impact, Environmental; Individual; Industrialized Countries; Industrialized Nations; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Keratitis; LCA; LY5; LYT3; Label; Lesion; Mammals, Rabbits; Man (Taxonomy); Man, Modern; Measures; Microscopy, Confocal; Modeling; Modification; Molecular; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Oryctolagus cuniculus; PTPRC; PTPRC gene; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Published Comment; Rabbit, Domestic; Rabbits; Recombinants; Recurrence; Recurrent; Research; Research Ethics Committees; Research Resources; Resources; Semilunar Ganglion; Simplexvirus; Staining method; Stainings; Stains; Structure; Structure of trigeminal ganglion; Suggestion; T-Cells; T-Lymphocyte; T200; Thymus-Dependent Lymphocytes; Time; Trigeminal Ganglias; Trigeminal Ganglion; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Virus; Viruses, General; abstracting; cell type; cicatrix corneal; clinical relevance; clinically relevant; corneal; corneal scar; experiment; experimental research; experimental study; expiration; gene product; healing; herpes simplex i; herpes virus 1, human; herpesvirus; host response; human alphaherpesvirus 1; human herpesvirus 1 group; human subject; imaging; immunoresponse; in vivo; neuronal; programs; protein function; recombinant virus; research study; response; thymus derived lymphocyte; vertebrata",Corneal HSV-1: Immunopathologic Mechanisms of HSK,,18171,ZRG1,Special Emphasis Panel,,3,378675,
7736790,R01,EY,5,,12/01/2009,11/30/2010,PA-07-070,5R01EY018571-03,,NEI:415917;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,GENETICS,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"CHEN, RUI ;",1944924;,5R01EY018571,12/01/2007,11/30/2011,"0-11 years old; 14q24; Accounting; Affect; Animal Model; Animal Models and Related Studies; Animal Welfare; Bibliography; Bio-Informatics; Bioinformatics; Candidate Disease Gene; Candidate Gene; Centrosome; Child; Child Youth; Children (0-21); Chromosome Mapping; Code; Coding System; Collection; Computer Simulation; Computerized Models; Control Groups; Country; DNA; DNA Molecular Biology; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disorder; Ecological impact; Elements; Enrollment; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exons; Expression Profiling; Expression Signature; Family; Family member; Foundations; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; General Population; General Public; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic Markers; Genetic defect; Genetics, Gene Mapping; Genome; Genome, Human; Genomics; Goals; Guanine Nucleotides; Guanosine Phosphates; Hereditary; Human; Human Genome; Human, Child; Human, General; IACUC; IMPD; IMPD1; IMPDH1; IMPDH1 gene; IRBs; Impact, Environmental; Infant; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Intervention; Intervention Strategies; Intervention, Genetic; Lead; Leber abiotrophy; Leber congenital amaurosis; Leber congenital amaurosis (LCA); Leber congenital tapetoretinal degeneration; Leber disease 2; Leber's amaurosis; Leber's congenital amaurosis; Leber's disease; Linkage Analysis; Linkage Mapping; METBL; Man (Taxonomy); Man, Modern; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Medical; Metabolic Processes; Metabolism; Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids; Methods; Models, Computer; Molecular; Molecular Biology; Molecular Biology, Gene Therapy; Molecular Diagnosis; Molecular Fingerprinting; Molecular Profiling; Mutation; Mutation Analysis; Names; National Eye Institute; Nature; Nucleotide Synthesis; Operation; Operative Procedures; Operative Surgical Procedures; Oral; Partial Sight; Pathway interactions; Patients; Pb element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phototransduction; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Trafficking; R01 Mechanism; R01 Program; RPE65; RPE65 protein; RPG; Research; Research Ethics Committees; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Retina; Retinal Diseases; Retinal Disorder; Retinal Dystrophy; Sampling; Saudi Arabia; Scanning; Short Tandem Repeat; Signal Transduction, Light; Simple Sequence Repeat; Simulation, Computer based; Surgical; Surgical Interventions; Surgical Procedure; Therapy, DNA; Traffickings, Protein; Variant; Variation; Vertebrate Animals; Vertebrates; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual Transduction; Visual impairment; Vitamin A; abstracting; amaurosis congenita of Leber; base; children; combinatorial; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; congenital amaurosis of retinal origin; congenital retinal blindness; congenital retinal blindness (CRB); congenital retinitis pigmentosa; design; designing; disease-causing mutation; disease/disorder; dysgenesis neuroepithelialis retinae; early onset; enroll; expiration; falls; family based linkage study; gene therapy; genetic linkage analyses; genetic linkage analysis; genetic mapping; genetic therapy; genome mutation; heavy metal Pb; heavy metal lead; hereditary epithelial dysplasia of retina; hereditary retinal aplasia; heredoretinopathia congenitalis; human subject; in silico; insight; interventional strategy; linkage analyses; model organism; molecuar profile; molecular signature; mutant; new diagnostics; next generation diagnostics; novel; novel diagnostics; nucleotide metabolism; pathway; positional cloning; programs; protein transport; retina disease; retina disorder; retinol; retinopathy; reverse genetics; surgery; tool; vertebrata; virtual simulation; visually impaired; youngster",Genetics of Early Onset Retinal Diseases,,18571,ZRG1,Special Emphasis Panel,,3,415917,
7754399,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018586-03,,NEI:378675;,2010,NATIONAL EYE INSTITUTE,,MIAMI,UNITED STATES,OPHTHALMOLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"WEN, RONG ;",2089892;,5R01EY018586,02/01/2008,01/31/2012,"Affect; Animal Welfare; Behavior; Behavior Control; Behavioral Manipulation; Bibliography; Blindness; CNTF; Cells; Cellular biology; Ciliary Neuronotrophic Factor; Ciliary Neurotrophic Factor; Clinical; Color Visions; Cone; Cones (Eye); Cones (Retina); Country; Data; Degenerative Disorder; Development; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Glia; Glial Cells; Hereditary; IACUC; IRBs; Impact, Environmental; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kolliker's reticulum; Lead; Literature; Mediating; Muller's cell; Names; Natural regeneration; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Part; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neuron Degeneration; Neurons; Non-neuronal cell; Pb element; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photosensitive Cell; Pigmentary Retinopathy; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Regeneration; Research; Research Ethics Committees; Research Resources; Resources; Retina; Retinal; Retinal Cone; Retinal Degeneration; Retinitis Pigmentosa; Rod; Rod Photoreceptors; Rod-Cone Dystrophy; Rods (Eye); Rods (Retina); Role; Side; Tapetoretinal Degeneration; Vertebrate Animals; Vertebrates; Visions, Color; Visual Receptor; abstracting; behavioral control; cell biology; clinical applicability; clinical application; cone cell; degenerative condition; degenerative disease; effective therapy; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; human subject; interest; light effects; nerve cement; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; neuroprotection; photoreceptor degeneration; programs; regenerate; release factor; research study; retina degeneration; retinal degenerative; rod cell; social role; vertebrata",CNTF and retinal degeneration: the role of Muller cells,,18586,BDPE,Biology and Diseases of the Posterior Eye Study Section,,3,378675,
7761658,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018612-03,,NEI:482205;,2010,NATIONAL EYE INSTITUTE,,CLEVELAND,UNITED STATES,OPHTHALMOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"PEARLMAN, ERIC ;",2096699;,5R01EY018612,02/01/2008,01/31/2013,"Accidents; Agriculture; Air; Animal Welfare; Anterior Chamber; Anterior Chamber of the Eye; Anterior chamber of eye structure; Antifungal Agents; Antifungal Drug; Apoptosis; Apoptosis Pathway; Asia, Southeastern; Awareness; Awarenesses; Bibliography; Biochemical Pathway; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; C-Type Lectins; Caring; Cell Death, Programmed; Cells; Cleaved cell; Collagen Fibril; Contact Lenses, Hydrophilic; Cornea; Corneal Stroma; Country; Descemet's Membrane; Descemet's membrane; Diagnostic; Disease Outbreaks; Dust; Ecological impact; Environment; Environmental Impact; Epithelial Cells; Epithelium; Epithelium, Anterior Corneal; Epithelium, Corneal; Equipment; Esteroproteases; Ethics Committees, Research; Fungi, Filamentous; Fungicides, Therapeutic; Fusarium; Genetics-Mutagenesis; Heterophil Granulocyte; Hydrophilic Contact Lenses; Hyphae; IACUC; IRBs; Immune; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Invaded; Keratitis; Lamina Elastica Posterior; Lectins, C-Type; Literature; Mammals, Mice; Marrow Neutrophil; Mediating; Metabolic Networks; Methods; Mice; Microbial Biofilms; Molds; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Names; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organism; Outbreaks; Pathogenesis; Penetration; Peptidases; Peptide Hydrolases; Peptides; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prevalence; Principal Investigator; Pro-Gly-Pro; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Proteomics; Reproduction spores; Research; Research Ethics Committees; Research Resources; Resources; Role; Rural; Soft Contact Lenses; Soil; Southeast Asia; Southeastern Asia; Spores; Structure of Descemet's membrane; Structure of corneal epithelium; Trauma; ULCN; Ulcer; Ulceration; Vegetables; Vertebrate Animals; Vertebrates; abstracting; agricultural; anterior chamber; anti-fungal; antifungals; biofilm; cleaved; corneal; corneal epithelial; corneal epithelium; dectin 1; dectin-2; dectin-2, mouse; dietary vegetable; experiment; experimental research; experimental study; expiration; gene product; human subject; improved; lens; living system; microbial; mouse dectin-2; mouse model; neutrophil; programs; prolyl-glycyl-proline; research study; social role; vertebrata",Pathogenesis of Fungal Keratitis,,18612,AED,Anterior Eye Disease Study Section,,3,482205,
7758301,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018621-03,,NEI:373725;,2010,NATIONAL EYE INSTITUTE,,EVANSTON,UNITED STATES,BIOLOGY,09,160079455,US,IL,602081110,NORTHWESTERN UNIVERSITY,"CANG, JIANHUA ;",8458955;,5R01EY018621,02/01/2008,01/31/2012,"Acquired brain injury; Affect; Area striata; Area striata structure; Axon; Behavior; Behavioral; Brain; Brain Injuries; Cognitive Discrimination; Cortex, Striate; Cues; Discrimination; Discrimination (Psychology); Disease; Disorder; Dorsal; Encephalon; Encephalons; Individual; Intervention; Intervention Strategies; Investigators; Knowledge; Lateral Geniculate Body; Mammals, Mice; Maps; Measures; Mice; Mice, Mutant Strains; Molecular; Murine; Mus; Mutant Strains Mice; NRVS-SYS; Names; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Organism-Level Process; Organismal Process; Output; Pattern; Physiologic Processes; Physiological Processes; Primary visual cortex; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Research; Research Personnel; Researchers; Retina; Role; Sensory; Shapes; Striate area; Swimming; Synapses; Synaptic; Testing; Visual; Visual Cortex; Visual System; Visual system structure; Whole-Cell Recordings; Wild Type Mouse; Work; area striata; brain damage; brain lesion (from injury); disease/disorder; experiment; experimental research; experimental study; gangliocyte; ganglion cell; interventional strategy; lateral geniculate; lateral geniculate nucleus; mouse mutant; neuronal; orientation preference; orientation selectivity; programs; receptive field; research study; response; retinotopic; social role; synapse inhibition; synaptic inhibition; visual cortical; visual process; visual processing",Topographic Maps and Visual Cortical Functions,,18621,CVP,Central Visual Processing Study Section,,3,373725,
7759139,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018828-02,,NEI:349718;,2010,NATIONAL EYE INSTITUTE,,CHICAGO,UNITED STATES,OPHTHALMOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"YUE, BEATRICE Y.J.T.;",1867564;,5R01EY018828,02/01/2009,01/31/2013,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Adeno-Associated Viruses; Adolescent; Adolescent Youth; Adult; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Autophagocytosis; Binding; Binding (Molecular Function); Biology; Cell Death; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chaperone; Common Rat Strains; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependovirus; Disease; Disorder; Doxycycline; Eukaryote; Eukaryotic Cell; Eye; Eyeball; Fluorescence; Ganglion Cells (Retina); Genes; Genetic Alteration; Genetic Change; Genetic defect; Glaucoma; Glaucoma Simplex; Glaucoma, Compensated; Glaucoma, Compensative; Glaucoma, Open-Angle; Glaucoma, Pigmentary; Glaucoma, Simple; HMG-20; High Mobility Protein 20; Human, Adult; Hypoxia; Hypoxic; Idiopathic Parkinson Disease; Impairment; In Vitro; Injection of therapeutic agent; Injections; Label; Laboratories; Lead; Lewy Body Parkinson Disease; Link; Lysosomes; Macropain; Macroxyproteinase; Mammals, Rats; Methods and Techniques; Methods, Other; Modality; Modeling; Molecular Chaperones; Molecular Interaction; Monitor; Multicatalytic Proteinase; Mutate; Mutation; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Open-Angle Glaucoma; Oxidative Stress; Oxygen Deficiency; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pb element; Physiologic pulse; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteins; Proteosome; Pulse; Rapamune; Rapamycin; Rat; Rattus; Research; Retinal Ganglion Cells; Role; Route; Sirolimus; Subcellular Process; System; System, LOINC Axis 4; Techniques; Testing; Transfection; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Vibramycin; Virus; Viruses, General; adeno associated virus group; adult human (21+); alpha-6-Deoxyoxytetracycline; autophagy; cultured cell line; dementia of the Alzheimer type; design; designing; disease/disorder; eukaryotida; experiment; experimental research; experimental study; gene product; genome mutation; glaucomatous; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; insight; juvenile; juvenile human; multicatalytic endopeptidase complex; mutant; myocilin; necrocytosis; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; new therapeutics; next generation therapeutics; novel therapeutics; overexpression; pathway; primary degenerative dementia; public health relevance; research study; retinal ganglion; senile dementia of the Alzheimer type; social role; ubiquination; ubiquitin conjugation","Cellular Processing of Optineurin, the Product of a Glaucoma Gene"," NARRATIVE Glaucoma is a major blinding disease. We propose a new study on optineurin, a gene associated with normal tension glaucoma. In particular, we will examine the processing of optineurin protein in neuronal cells. Results obtained from the proposed studies will provide insights into the basic biology of optineurin and help illustrate how glaucoma is developed. In addition, the new information may lead to novel therapeutic modalities.",18828,AED,Anterior Eye Disease Study Section,,2,349718,
7754383,R01,EY,5,,01/01/2010,12/31/2010,PA-07-070,5R01EY018850-02,,NEI:483863;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,09,073826000,US,MA,02114,SCHEPENS EYE RESEARCH INSTITUTE,"GIPSON, ILENE K.;",1887437;,5R01EY018850,01/01/2009,12/31/2012,"3-10C; AMCF-I; Adhesions; Affect; Alimentary Canal; Apical; Assay; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bacteria; Bacterial conjunctivitis; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; CXCL8; Cell Line; Cell Lines, Strains; Cell surface; CellLine; Cells; Characteristics; Clinical; Conjunctivitis; Cornea; D. pneumoniae; D.pneumoniae; DIF; Data; Differentiation Factor, B-Cell; Digestive Tract; Diplococcus pneumoniae; Disease Outbreaks; Encapsulated; Epidemic; Epithelial; Epithelial Cells; Epithelium; Exposure to; Eye; Eye Infections; Eyeball; Film; GCP-1; GCP1; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Genes; Genitourinary; Genitourinary system; Goblet Cells; HPGF; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL-8; IL6 Protein; IL8; IL8 gene; In Vitro; Infection; Injury; Interleukin 6 (Interferon, Beta 2); Interleukin-6; K60; Keratitis; LECT; LUCT; LYNAP; Laboratories; MDNCF; MGI-2; MONAP; MUC1; MUC5AC; MUC5AC gene; Man (Taxonomy); Man, Modern; Membrane; Metabolic Glycosylation; Microbe; Modeling; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucin-1 Staining Method; Mucins; Mucosa; Mucosal Tissue; Mucous Membrane; Mucus Glycoprotein; Myeloid Differentiation-Inducing Protein; NAF; Ocular Infections; Organism; Outbreaks; Pathogenesis; Pattern; Plasmacytoma Growth Factor; Pneumococcal Infections; Pneumococcus; Position; Positioning Attribute; Pulmonary Body System; Pulmonary Organ System; RNA, Small Interfering; Receptor Protein; Research; Respiratory System; Respiratory system (all sites); Respiratory tract structure; S. aureus; S. pneumoniae; S.aureus; SCYB8; Small Interfering RNA; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pneumoniae Infections; Stress; Surface; Systems Analyses; Systems Analysis; TNF; TNF A; TNF gene; TNFSF2; TSG-1; Testing; Tissue membrane; Tissues; Tracts, Respiratory; Trauma; Tumor Necrosis Factor Gene; Urogenital; Urogenital System; alimentary tract; alternative treatment; b-ENAP; corneal; cultured cell line; cytokine; density; digestive canal; glycosylation; insight; interferon beta 2; limbal; living system; membrane structure; new approaches; novel approaches; novel strategies; novel strategy; ocular surface; pathogen; pneumococcal disease; pneumococcus infection; prevent; preventing; public health relevance; receptor; respiratory tract; response; siRNA; urogenital system (urinary part)",Bacteria-Mucin Interactions at the Ocular Surface," Project Narrative Infection remains a leading cause of morbidity and mortality worldwide, and most infections originate at a mucosal boundary¨the mucosal surface of the respiratory tract, gastrointestinal tract, urogenital tract or the eye. Mucins on the wet-surfaced mucosa are hypothesized to provide a barrier against continuous exposure to trillions of microbes, and preliminary data from our laboratory indicate that, of the two types of mucins on these epithelia, secreted or membrane associated, it is the membrane-associated mucins integral to surface membranes that form this cellular barrier. The research proposed in this application will provide new information about how bacteria that cause epidemic conjunctivitis are more capable of crossing the membrane mucin barrier than are the opportunistic pathogens and, in doing so, will provide clues for treatment alternatives.",18850,AED,Anterior Eye Disease Study Section,,2,483863,
7756611,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY018876-02,,NEI:353455;,2010,NATIONAL EYE INSTITUTE,,IRVINE,UNITED STATES,PEDIATRICS,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"HUANG, TAOSHENG ;",2052604;,5R01EY018876,02/01/2009,01/31/2013,"21+ years old; Abscission; Active Oxygen; Adult; Affect; Animal Model; Animal Models and Related Studies; Antioxidants; Apoptosis; Apoptosis Inhibitor; Apoptosis Pathway; Arts; Auditory Prosthesis; Autosomal Dominant Optic Atrophy; Blindness; Caspase Inhibitor; Cell Communication and Signaling; Cell Death; Cell Death, Programmed; Cell Signaling; Cells; Clinical; Clinical Evaluation; Clinical Testing; Cochlear Implants; Cochlear Prosthesis; Color Visions; Color vision defect; Cone; Cones (Eye); Cones (Retina); Data; Defective Color Vision; Degenerative Disorder; Dephosphin; Deposit; Deposition; Development; Disease; Disorder; Dominant Optic Atrophy; Drosophila; Drosophila eye; Drosophila genus; Drug Evaluation, Preclinical; Drug Screening; Drugs; Dynamin; Dysfunction; Effectiveness; Embryo; Embryonic; Erythrocuprein; Esteroproteases; Evaluation; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Excision; Extirpation; Eye; Eyeball; Family; Ferricytochrome c; Ferrocytochrome c; Flies; Fruit Fly, Drosophila; Functional disorder; GTP Binding; Ganglion Cells (Retina); Gatekeeping; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Techniques; Genetic defect; Hearing; Hearing Loss; Hearing Tests; Hemocuprein; Human; Human, Adult; Human, General; Hypoacuses; Hypoacusis; Inner mitochondrial membrane; Intracellular Communication and Signaling; Knock-out; Knockout; Lead; Length of Life; Link; Longevity; Man (Taxonomy); Man, Modern; Medication; Microscope; Mitochondria; Mitochondrial Membrane Protein; Mitochondrial Proteins; Modeling; Molecular; Motor; Mutation; Mutation Analysis; N-terminal; NH2-terminal; Nuclear; Older Population; Optic Atrophy; Optic Atrophy Type 1; Optic Atrophy, Autosomal Dominant; Optic Atrophy, Hereditary, Autosomal Dominant; Optic Atrophy, Kjer Type; Optic Disk; Optic Nerve Head; Optic Papilla; Optics; Organ; Ortholog; Orthologous Gene; Oxidative Stress; Oxygen Radicals; P element; Pallor; Pathogenesis; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphorus; Photoreceptors, Cone; Physiopathology; Pigments; Play; Population; Power Plants; Preclinical Drug Evaluation; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Publications; Reactive Oxygen Species; Recruitment Activity; Removal; Research; Respiration; Retinal Cone; Retinal Degeneration; Retinal Diseases; Retinal Disorder; Retinal Ganglion Cells; Role; SOD; SOD-1 protein; SOD1 gene product; Scientific Publication; Scotoma; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stress; Superoxide Dismutase; Superoxide[{..}]superoxide oxidoreductase; Surgical Removal; TM Domain; Technics, Genetic; Technology; Testing; Therapeutic Agents; Transmembrane Domain; Transmembrane Region; Visions, Color; Visual Acuity; Visual Field Disorder; Visual field scotoma; Vitamin E; adult human (21+); anti-oxidant; biological signal transduction; clinical phenotype; clinical relevance; clinical test; clinically relevant; cone cell; cytochrome c; cytocuprein; degenerative condition; degenerative disease; demographics; disease/disorder; drug/agent; fly; fruit fly; gatekeeper; gene product; genome mutation; hearing impairment; hearing perception; heavy metal Pb; heavy metal lead; human subject; improved; insight; lens; life span; lifespan; mitochondrial; mitochondrial dysfunction; model organism; mutant; necrocytosis; novel; overexpression; pathophysiology; pathway; patient population; presenilin; prevent; preventing; programs; public health relevance; recruit; research clinical testing; resection; respiratory mechanism; retina degeneration; retina disease; retina disorder; retinal degenerative; retinal ganglion; retinopathy; rhomboid; social role; sound perception; superoxide dismutase 1; visual field defect",Genetic Studies of Optic Atrophy," PROJECT NARRATIVE Optic atrophy gene 1 (OPA1) programs proteins found in mitochondria, the power plant of cells in our body. For example we have found that mutations of OPA1 cause optic atrophy as well as hearing loss. We were also surprised to find that Opa1 mutation affects the life span in fly. In this study, we will clinically evaluate patients with known mutation of OPA1 to further expand our understanding of the effects of this gene on other organs. We will closely discern how optic atrophy is caused in fly model. In addition, we can also use this model to screen drug for treatments of optic atrophy. By understanding how Opa1 affect the life span, we may develop a drug to prolong the life span. This study will allow us to understand how mutations of OPA1 cause optic atrophy and explore its novel function in lifespan and provide us a potential opportunity to develop treatments for the disease.",18876,NOMD,Neural Oxidative Metabolism and Death Study Section,,2,353455,
7797397,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY019053-02,,NEI:298868;,2010,NATIONAL EYE INSTITUTE,,BALTIMORE,UNITED STATES,BIOLOGY,07,061364808,US,MD,21250,UNIVERSITY OF MARYLAND BALT CO CAMPUS,"ROBINSON, PHYLLIS R;",1891955;,5R01EY019053,04/01/2009,01/31/2013,"Arrestins; Behavior; Behavioral; Binding; Binding (Molecular Function); Biochemical; Biochemical Pathway; Biochemistry; Biology; Blindness; Brain; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chemistry, Biological; Circadian Rhythms; Cone; Cones (Eye); Cones (Retina); Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disease; Disorder; Diurnal Rhythm; EC 2.7; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Exhibits; Family; Family member; Future; G Protein-Complex Receptor; G alpha q Protein; G-Protein, Gq; G-Protein, Gq alpha Family; G-Protein-Coupled Receptors; G-Proteins; GRK; GTP Binding Protein alpha Subunit, Gq; GTP-Binding Proteins; GTP-Regulatory Proteins; Galphaq Protein; Ganglion Cells (Retina); Genetic Alteration; Genetic Change; Genetic defect; Goals; Gq Protein; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Hour; Intracellular Communication and Signaling; Intracellular Second Messengers; Invertebrata; Invertebrates; Invertebrates, General; Kinases; Lecithinase C; Light; Light Adaptations; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Mediating; Metabolic Networks; Mice; Mice, Transgenic; Modification; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mouse Strains; Murine; Mus; Mutagenesis, Site-Directed; Mutation; Natural regeneration; Nature; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurophysiology / Electrophysiology; Nyctohemeral Rhythm; Opsin; Pathway interactions; Peripheral; Pharmacological Treatment; Phospholipase C; Phosphorylation; Phosphotransferases; Photochemistry; Photometry/Spectrum Analysis, Mass; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photoreceptors, Vertebrate; Photosensitive Cell; Phototransduction; Physiologic; Physiological; Physiology; Pigments; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; R01 Mechanism; R01 Program; RPG; RT-PCR; RTPCR; Receptor Protein; Regeneration; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Retina; Retinal; Retinal Cone; Retinal Ganglion Cells; Retinal Pigments; Reverse Transcriptase Polymerase Chain Reaction; Rod-Opsin; Rods and Cones; Role; Second Messenger Systems; Second Messengers; Sensory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signal Transduction, Light; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sleep Disorders; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Structure of suprachiasmatic nucleus; Subcellular Process; Suprachiasmatic Nucleus; Synapses; Synaptic; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Transgenic Mice; Transphosphorylases; Travel; Twenty-Four Hour Rhythm; Vertebrate Photoreceptors; Visual Pigments; Visual Receptor; Visual Transduction; base; behavior test; behavioral test; biological signal transduction; circadian; circadian clock; circadian pacemaker; circadian process; cone cell; daily biorhythm; day shift; design; designing; disease/disorder; diurnal variation; experience; experiment; experimental research; experimental study; gangliocyte; ganglion cell; gene product; genome mutation; in vitro Assay; in vivo; interdisciplinary approach; interest; light entrainment; lipophosphodiesterase I; melanopsin; member; neurodegenerative illness; night shift; night work; novel; patch clamp; pathway; phosphatidylcholine cholinephosphohydrolase; public health relevance; receptor; regenerate; research study; response; retina photosensitive pigment; retinal ganglion; reverse transcriptase PCR; second messenger; shift work; sleep problem; social role; suprachiasmatic nucleus",Molecular characterization of mouse melanopsin and second messenger pathway.,"  Many aspects of mammalian physiology and behavior exhibit a daily 24 hour rhythm. These daily oscillations are circadian rhythms and are controlled by a brain structure known as the suprachiasmatic nucleus. The mammalian circadian clock is constantly being reset by the onset of environmental light. Light entrainment of the clock requires input from the retina, which communicates with the suprachiasmatic nucleus via the axonal projections of a small subset of retinal ganglion cells. Surprisingly, classical photoreceptors, rods and cones are not necessary; instead, suprachiasmatic nucleus - projecting retinal ganglion cells function as autonomous photoreceptors. These ganglion cells also express a novel vertebrate visual pigment, known as melanopsin, which is necessary for initiating the light response in these cells. The proposed research project aims to characterize melanopsin. Understanding the signaling cascade activated by melanopsin is of great interest and significance for the field of sensory biology and circadian rhythms. In addition, disorders of the circadian system often accompany neurodegenerative diseases, sleep disorders, and blindness, and are more commonly experienced as a result of transmeridian travel and shift work. In the future, elucidation of the melanopsin-based signaling cascade should allow us to develop successful pharmacological treatments for these disorders.",19053,BDPE,Biology and Diseases of the Posterior Eye Study Section,,2,298868,
7756614,R01,EY,5,,02/01/2010,01/31/2011,PA-07-070,5R01EY019304-02,,NEI:441274;,2010,NATIONAL EYE INSTITUTE,,PHILADELPHIA,UNITED STATES,OTHER CLINICAL SCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KOMAROMY, ANDRAS ;",9016121;,5R01EY019304,02/01/2009,01/31/2014,"AAV vector; Affect; Age related macular degeneration; Age-Years; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Biogenesis; Biological Preservation; Blindness; Body Tissues; CNG channel (rod); Canine Species; Canis familiaris; Catalytic RNA; Clinical Trials, Phase I; Color; Color Visions; Common Rat Strains; Complementary DNA; Cone; Cones (Eye); Cones (Retina); DNA, Complementary; Data; Defect; Development; Disease; Disease Progression; Disease model; Disorder; Dogs; Drugs, Nonproprietary; Dysfunction; Early-Stage Clinical Trials; Europe; Evaluation; Eye; Eyeball; Functional disorder; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generic Drugs; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Intervention; Genetic defect; Genomics; Goals; Health; Hereditary; Hereditary Disease; Human; Human, General; Inherited; Intervention, Genetic; Lead; Life; Maculopathy, Age-Related; Mammals, Dogs; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Metric; Mice; Missense Mutation; Modality; Modeling; Molecular; Molecular Biology, Gene Therapy; Molecular Disease; Monitor; Murine; Mus; Mutation; Mutation, Missense; Origin of Life; Outer pigmented layer of retina; Patients; Pattern; Pb element; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Phenotype; Photoreceptor Cell; Photoreceptors; Photoreceptors, Cone; Photosensitive Cell; Physiopathology; Pigment cell layer of retina; Pigmentary Retinopathy; Pigmented layer of retina; Preservation, Biologic; Preservation, Biological; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; RNA, Messenger; Rat; Rattus; Recombinant adeno-associated virus; Recombinant adeno-associated virus (rAAV); Reporting; Research Proposals; Retina; Retinal; Retinal Cone; Retinal Diseases; Retinal Disorder; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Retinitis Pigmentosa; Ribozymes; Rod-Cone Dystrophy; Rodent Model; Safety; Science of Anatomy; Sight; Specificity; Staging; Structure; Structure of retinal pigment epithelium; Tapetoretinal Degeneration; Testing; Therapeutic; Therapy, DNA; Time; Tissues; Toxic effect; Toxicities; Transgenes; Translations; Treatment outcome; Vision; Visions, Color; Visual Acuity; Visual Receptor; achromatopsia; adeno-associated viral vector; adeno-associated virus vector; age effect; aging effect; anatomy; base; cDNA; canine; cationic channel protein (rod); cone cell; cyclic-nucleotide gated channel; cyclic-nucleotide gated ion channels; design; designing; disease phenotype; disease/disorder; disorder model; domestic dog; early onset; gain of function mutation; gene product; gene replacement; gene replacement therapy; gene therapy; generic; genetic disorder; genetic therapy; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; improved; loss of function mutation; mRNA; man; man's; model organism; monolayer; mutant; neurotrophic factor; neurotrophin; neutrophin; pathophysiology; phase 1 study; phase 1 trial; phase I trial; preservation; prevent; preventing; protocol, phase I; public health relevance; restoration; retina disease; retina disorder; retinopathy; senile macular disease; success; transgene expression; visual performance",Achromatopsia - Disease Mechanisms and Cone-Directed Gene Therapy,,19304,ZRG1,Special Emphasis Panel,,2,441274,
7754378,R01,EY,5,,01/01/2010,12/31/2010,PA-07-070,5R01EY019413-02,,NEI:364061;,2010,NATIONAL EYE INSTITUTE,,IRVINE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"ANDERSEN, BOGI ;",7940442;,5R01EY019413,01/01/2009,12/31/2012,"Adhesion Molecule; Adhesions; Affect; Antimorphic mutation; Assay; Autoregulation; Basal lamina; Bioassay; Biologic Assays; Biological Assay; Bleb; Blindness; Blister; Bulla; Bullous Lesion; CHIP assay; CRR Domain; Cell Adhesion; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Cellular Adhesion; ChIP (chromatin immunoprecipitation); Computational algorithm; Confocal Microscopy; Cornea; Corneal Diseases; Corneal Disorder; Cysteine Rich Region; DNA-Binding Proteins; Data; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Epidermis; Epithelial; Epithelial Cells; Epithelium; Epithelium, Anterior Corneal; Epithelium, Corneal; Expression Profiling; Expression Signature; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profile; Gene Expression Profiling; Gene Family; Gene Transcription; Genes; Genetic Transcription; Goals; Hair; Hemidesmosomes; Homeostasis; Image; Inflammatory Response; Intracellular Communication and Signaling; Keratin; LIM Domain; Lead; Link; Maintenance; Maintenances; Mammals, Mice; Mice; Mice, Transgenic; Microscopy, Confocal; Molecular; Molecular Fingerprinting; Molecular Profiling; Mother Cells; Murine; Mus; Pathogenesis; Pb element; Phenotype; Physiological Homeostasis; Play; Process; Profilings, Gene Expression; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Public Health; RNA Expression; Regulation; Research; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Squamous Metaplasia; Stem cells; Structure; Structure of corneal epithelium; Testing; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription, Genetic; Transgenic Mice; Vesication; Vitamin A; Work; biological signal transduction; cell adhesion protein; chromatin immunoprecipitation; cornea disorder; corneal; corneal epithelial; corneal epithelial cell adhesion; corneal epithelium; disease/disorder; gene expression signature; gene product; heavy metal Pb; heavy metal lead; imaging; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; light transmission; limbal; member; molecuar profile; molecular signature; neovascularization; notch; notch protein; notch receptors; novel; prevent; preventing; public health medicine (field); public health relevance; response; retinol; social role; transcription factor; transcriptome; transgene expression",Epithelial differentiation in cornea," There are several blistering diseases that affect the cornea, frequently leading to limbal stem cell deficiency. The K14-DN-Clim mice reproduce these features and may provide insights into the response of the cornea to such insults and lead to ideas about new drug targets. Squamous metaplasia and altered differentiation are also a hallmark of several corneal diseases that cause blindness; understanding the mechanisms whereby epidermis-like differentiation is prevented in the cornea is highly significant to public health.  ",19413,ZRG1,Special Emphasis Panel,,2,364061,
7742236,R01,GM,5,,12/01/2009,11/30/2010,,5R01GM020964-36,,NIGMS:635609;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,PATHOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"WEIGERT, MARTIN G;",3106937;,5R01GM020964,01/01/1977,11/30/2010,"Affinity; Antibodies; Antibody Repertoire; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; B blood cells; B cell repertoire; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Clonal Expansion; Code; Coding System; DNA Binding; DNA Binding Interaction; DNA Rearrangement; DNA receptor; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diathesis; Disease; Disease Management; Disease Progression; Disease susceptibility; Disorder; Disorder Management; Enhancers; Evolution; FLR; Failure (biologic function); Fc Receptor; FcR; Frequencies (time pattern); Frequency; Gene Rearrangement; GeneHomolog; Genealogy; Geneologies; Genes; Genetic; Germinal Center; Glean; Health; Homolog; Homologous Gene; Homologue; Human; Human, General; Immunoglobulin V(D)J Rearrangement; Individual; Location; Lupus; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Mature B-Cell; Mature B-Lymphocyte; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Monitor; Multiple Sclerosis; Murine; Mus; Pattern; Population; Process; Production; Property; Property, LOINC Axis 2; Receptor Protein; Regulation; Residual; Residual state; Resolution; Risk; Risk Factors; Role; SLE; SLE - Lupus Erythematosus, Systemic; Sclerosis, Disseminated; Shapes; Site; Somatic Mutation; Specificity; Structure; Structure of germinal center of lymph node; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; Techniques; Testing; Transgenes; Transgenic Mice; Transgenic Organisms; V(D)J Rearrangement; V(D)J Recombination; VDJ rearrangement; VDJ recombination; antibody receptor; autoimmune antibody; autoimmune disorder; autoreactive B cell; base; clinical data repository; clinical data warehouse; data repository; disease diagnosis; disease/disorder; disease/disorder proneness/risk; disseminated lupus erythematosus; experiment; experimental research; experimental study; failure; insular sclerosis; interest; liability to disease; microarray technology; prevent; preventing; receptor; relational database; research study; self reactive antibody; self recognition (immune); social role; systemic autoimmune disease; systemic lupus erythematosis; transgenic",Genetics and Regulation of Autoantibodies,,20964,CMIB,Cellular and Molecular Immunology - B Study Section,,36,635609,
7753156,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM023467-34,,NIGMS:483778;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"RECORD, M. THOMAS;",1887226;,5R01GM023467,01/01/1977,12/31/2010,"Active Sites; Address; Affect; Affinity; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Area; Assay; Bacteria; Bacterial Infections; Bacteriophages; Base Pairing; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Burial; Calorimetry; Cancers; Carbamide; Cellulose Nitrate; Chemicals; Circular Dichroism; Cleaved cell; Combining Site; Complex; Coupled; Coupling; Cues; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; DNA Footprint; DNA Sequence; DNA Sequence Rearrangement; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Deoxyribonucleic Acid; Development; Dissociation; E coli; EC 2.7.7.6; Elaqua XX; Elements; Enzymes; Escherichia coli; Exhibits; FLR; FRET; Failure (biologic function); Fluorescence; Fluorescence Resonance Energy Transfer; Footprint, DNA; Free Energy; Gene Transcription; GeneHomolog; Genetic Transcription; Goals; HU Protein; Health; Homolog; Homologous Gene; Homologue; Host Factor; Host Factor Protein; Human; Human, General; Hydroxyl; Hydroxyl Radical; Integration Host Factors; Investigators; Kinetic; Kinetics; Lac Repressors; Length; Ligands; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Masks; Measures; Miscellaneous Antibiotic; Molecular Interaction; Nature; Nitrocellulose; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Phages; Physiologic; Physiological; Polymerase; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Motifs, DNA-Binding; Proteins; Public Health; Pyroxylin; RNA Expression; RNA Polymerases; RNA chemical synthesis; RNA synthesis; Reactive Site; Rearrangement; Regulation; Repressors, Lac; Research; Research Personnel; Researchers; Resolution; Role; Scanning; Site; Sites, Active; Sodium Chloride; Sodium chloride (NaCl); Solutions; Specificity; Staging; Structure; Surface; System; System, LOINC Axis 4; Temperature; Testing; Thermodynamic; Thermodynamics; Time; Titrations; Transcription; Transcription Initiation; Transcription, Genetic; Tuberculosis; Urea; Urea Carbamide; Ureaphil; Variant; Variation; bacterial disease; bacterial virus; cleaved; cross-link; crosslink; dimer; disseminated TB; disseminated tuberculosis; enthalpy; failure; gene product; human disease; malignancy; monomer; mutant; neoplasm/cancer; next generation; novel; programs; public health medicine (field); salt; social role; solute; transcription factor; tuberculous spondyloarthropathy",Large-Scale Conformational Changes in Regulation of Transcription Initiation,,23467,MGA,Molecular Genetics A Study Section,,34,483778,
7752494,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM026237-31,,NIGMS:256224;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHESTNUT HILL,UNITED STATES,CHEMISTRY,04,045896339,US,MA,02467,BOSTON COLLEGE,"KANTROWITZ, EVAN R;",1868717;,5R01GM026237,06/01/1996,12/31/2011,"(S)-Dihydroorotate amidohydrolase; 1,3 diazine; Address; Allosteric Regulation; Animal Welfare; Anti-Malarials; Anti-diabetic Agents; Antidiabetic Agents; Antidiabetic Drugs; Antidiabetic Hormone; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Arts; Aspartate; Bibliography; Binding; Binding (Molecular Function); Biological; Blood Glucose; Blood Sugar; Carbamoyl Transferases; Carbamoylaspartic Dehydrase; Cell Communication and Signaling; Cell Signaling; Cells; Country; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Data; Development; Dihydro-Orotase; Dihydro-Orotate Amidohydrolase; Dihydroorotase; Ecological impact; Environment; Environmental Impact; Enzymes; Equipment; Ethics Committees, Research; Fluorescent Probes; Fructose; GCG; Glucagon; Glucagon (1-29); Gluconeogenesis; Glukagon; HG-Factor; Humulin R; Hyperglycemic-Glycogenolytic Factor; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; International; Intracellular Communication and Signaling; L-Aspartate; Levulose; Metabolic Control; Metabolic Pathway; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Monitor; Motion; Movement; Names; Novolin R; Nucleotide Biosynthesis; Pathway interactions; Principal Investigator; Probes, Fluorescent; Process; Programs (PT); Programs [Publication Type]; Protein Subunits; Proteins; Public Health; Pyrimidine; Pyrimidine Nucleotides; Pyrimidines; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Roentgen Rays; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Single Crystal Diffraction; System; System, LOINC Axis 4; Techniques; Time; Transmission; Vertebrate Animals; Vertebrates; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; abstracting; anti-diabetic drugs; antidiabetic; base; biological signal transduction; biological systems; body movement; carbamoyltransferase; cooperative study; design; designing; expiration; gene product; glucose biosynthesis; human subject; inhibitor; inhibitor/antagonist; pathway; programs; public health medicine (field); receptor; transcarbamoylase; transmission process; vertebrata",The Molecular Basis of Cellular Control Mechanisms,,26237,ZRG1,Special Emphasis Panel,,31,256224,
7751206,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM028521-28,,NIGMS:382058;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"GERACE, LARRY R;",1867378;,5R01GM028521,04/01/1988,12/31/2010,"21+ years old; Adult; Affect; Asialogangliosides; Binding; Binding (Molecular Function); Body Tissues; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Ceramide (lipids); Ceramides; Defect; Disease; Disorder; Envelope Protein; Expression Profiling; Expression Signature; Focus Groups; Gene Expression; Gene Inactivation; Gene Products, env; Gene Silencing; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glycosphingolipids; Heart; Hereditary; Human; Human, Adult; Human, General; Hydrolase; In Vitro; Inherited; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Lamin A; Lamin Type A; Lamins; Light; Link; Lipid Rafts, Cell Membrane; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Membrane Microdomains; Modeling; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Muscle; Muscle Cells, Embryonic; Muscle Cells, Precursor; Muscle Development; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Muscular Development; Mutation; Myoblasts; Nuclear Envelope; Nuclear Inner Membrane; Nuclear Lamina; Nuclear Membrane; Nuclear Structure; Nucleus; Pathway interactions; Pattern; Photoradiation; Polymers; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Proteins; Proteomics; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Relative; Relative (related person); Role; Sequence Homology; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Skeletal Muscle Tissue; Skeletal muscle structure; Sphingoglycolipids; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Sphingolipids; Striated Muscle Tissue; Striated Muscles; Structure; Subcellular Process; Testing; Tissues; Transmembrane Protein; Type V IF Protein; Work; adult human (21+); base; biological signal transduction; disease/disorder; env Antigens; env Gene Products; env Polyproteins; env Protein; gene product; genome mutation; homology (molecular); human disease; insight; lipid raft; molecuar profile; molecular signature; novel; pathway; protein complex; protein function; response; social role",Organization and Functions of the Nuclear Lamina,,28521,NDT,Nuclear Dynamics and Transport,,28,382058,
7763248,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM030859-27,,NIGMS:356421;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"OVERMAN, LARRY E.;",1864223;,5R01GM030859,08/01/1982,01/31/2012,"9-azafluorene; 9H-carbazole; Alkaloids; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Architecture; Area; Azepines; Biological; Biological Factors; C element; Carbon; Chemicals; Chemistry; Complex; Cyclization; Development; Disease; Disorder; Drugs; Engineering / Architecture; Factor, Biologic; Family; Funding; Heterocyclic Amines; Hexamethyleneimines; Life; Medical; Medication; Medicine; Methods; Modeling; Molecular; NIGMS; National Institute of General Medical Sciences; Natural Products; Organic Synthesis; Parents; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Research; Science of Chemistry; Science of Medicine; Screening procedure; Series; Structure; System; System, LOINC Axis 4; carbazole; chemical synthesis; corymine; dibenzo(b,d)pyrrole; dibenzopyrrole; diphenylenimine; disease/disorder; drug/agent; enantiomer; improved; innovate; innovation; innovative; member; novel; programs; screening; screenings; verticillin A",General Methods for Synthesis of Bioactive Materials,,30859,SBCB,Synthetic and Biological Chemistry B Study Section,,27,356421,
7763188,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM031575-27,,NIGMS:586925;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN ANTONIO,UNITED STATES,,20,007936834,US,TX,782450549,SOUTHWEST FOUNDATION FOR BIOMEDICAL RES,"ALMASY, LAURA A.;",1930500;,5R01GM031575,04/01/1983,01/31/2012,"Animal Welfare; Applications Grants; Authorization; Authorization documentation; Base Sequence; Bibliography; Complex; Computer Programs; Computer software; Computers; Country; Data; Data Set; Dataset; Development; Disease; Disorder; Ecological impact; Educational process of instructing; Educational workshop; England; Environment; Environmental Impact; Epidemiologist; Equipment; Ethics Committees, Research; Evaluation; Framingham Heart Study; France; Funding; Future; GWAS; Gene Transcription; Genes; Genetic; Genetic Transcription; Genetic analyses; Genome Scan; Genotype; Germany; Goals; Grant; Grant Proposals; Grants, Applications; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Maps; Methods; Methods and Techniques; Methods, Other; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Names; Netherlands; Nucleotide Sequence; PROV; Participant; Permission; Phenotype; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Provider; Publishing; RNA Expression; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Risk Factors; Simulate; Software; Statistical Methods; Suggestion; Teaching; Techniques; Time; Transcription; Transcription, Genetic; Vertebrate Animals; Vertebrates; Workshop; abstracting; analytical method; base; computer program/software; density; disease/disorder; distributed data; expiration; genetic analysis; genetic epidemiology; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human subject; meetings; nucleic acid sequence; programs; transcriptomics; vertebrata; whole genome association studies; whole genome association study",Genetic Analysis of Common Diseases: An Evaluation,,31575,GCAT,"Genomics, Computational Biology and Technology Study Section",,27,586925,
7797431,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM034767-22,,NIGMS:358376;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LITT, LAWRENCE ;",1864494;,5R01GM034767,07/01/1985,01/31/2013,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; 4-hydroxy-3-methoxyacetophenone; Acetates; Acids, Perchloric; Active Oxygen; After Care; After-Treatment; Aftercare; Alanine; Alanine, L-Isomer; Algorithms; Aminalon; Aminalone; Anesthesia; Anesthesia procedures; Antioxidants; Asphyxia; Attenuated; Binding; Binding (Molecular Function); Biochemical Reaction; Biological Preservation; Body Temperature; Body Tissues; Brain; Butanoic acid, 4-amino-; Cell membrane; Citric Acid Cycle; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Control Groups; Creatine; Creatine Phosphate; Cytoplasmic Membrane; D-Glucose; Data; Dextrose; EC 1.1.3.22; Educational workshop; Electron Transport; Encephalon; Encephalons; Enzymatic Reaction; Ethanesulfonic acid, 2-amino-; Ethidium; Evaluation; Fluorescence; Fluorescence Microscopy; GABA; Genomics; Glia; Glial Cells; Gln; Glucose; Glutamates; Glutamine; Glycine, N-(aminoiminomethyl)-N-methyl-; Glycine, N-(imino(phosphonoamino)methyl)-N-methyl-; Goals; Hexose Monophosphate Shunt; Hour; Human; Human, General; Hypothermia; Hypoxanthine Dehydrogenase; Hypoxanthine Oxidase; Hypoxanthine-Xanthine Oxidase; Hypoxia; Hypoxic; Image Analyses; Image Analysis; Infant; Injury; Intermediary Metabolism; Kolliker's reticulum; Krebs Cycle; L-Alanine; L-Glutamate; L-Glutamine; L-aspartic acid, compd. with L-arginine (1[{..}]1); Label; Location; METBL; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Malates; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Mitochondria; Modeling; Molecular Interaction; Monitor; Multivariate Analyses; Multivariate Analysis; NADPH Oxidase; NIH; NMR Imaging; NMR Spectroscopy; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Neonatal; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic outcome; Neurological outcome; Neuronal Injury; Neurons; Non-neuronal cell; Nuclear Magnetic Resonance Imaging; Nutrient; O element; O2 element; Outcome; Outcome Measure; Oxidases; Oxidative Stress; Oxygen; Oxygen Deficiency; Oxygen Radicals; Pathway interactions; Pentose Phosphate Pathway; Pentose Phosphate Shunt; Pentose Shunt; Pentosephosphate Pathway; Pentosephosphate Shunt; Perchloric Acids; Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-; Phosphates; Phosphocreatine; Phosphorylcreatine; Physiologic; Physiological; Plasma Membrane; Preservation, Biologic; Preservation, Biological; Pro-Oxidants; Production; Proteomics; Protocol; Protocols documentation; Publications; Purine-Xanthine Oxidase; Pyruvate; Pyruvate Carboxylase; Pyruvate[{..}]carbon-dioxide ligase (ADP-forming); Pyruvates; Q. Levoglutamide; R01 Mechanism; R01 Program; ROC Analysis; RPG; Randomized Clinical Trials; Rat; Rattus; Reactive Oxygen Species; Recycling; Regimen; Relative; Relative (related person); Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Rewarming; Rodent; Rodent Model; Rodentia; Rodentias; Role; Scientific Publication; Slice; Spectroscopy, NMR; Succinates; Suffocation; Superoxide Anion; Superoxide Radical; Superoxides; TCA cycle; Tauphon; Taurine; Techniques; Temperature; Therapeutic; Time; Tissues; Treatment outcome; Trials, Randomized Clinical; Tricarboxylic Acid Cycle; United States National Institutes of Health; Workshop; Xanthine Oxidase; Xanthine[{..}]oxygen oxidoreductase; Zeugmatography; acetovanillone; anti-oxidant; apocynin; apocynine; arginine aspartate; asphyxiation; base; clinical investigation; clinical practice; deprivation; electron transfer; ethanolamine phosphate; ethyl pyruvate; experience; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; homidium; hypothermia, natural; image evaluation; improved; in vivo; inhibitor; inhibitor/antagonist; inorganic phosphate; measurement of metabolism; metabolomics; mitochondrial; myoinositol; natural hypothermia; neonate; nerve cement; neuron injury; neuronal; nitrone; nuclear magnetic resonance spectroscopy; pathway; phosphoethanolamine; phosphorylethanolamine; plasmalemma; preservation; public health relevance; pyruvate dehydrogenase; pyruvic carboxylase; reaction rate; research study; response; social role; therapy duration","Hypothermia, anesthesia and NMR metabolomics in ischemic neonatal brain slices"," PROJECT NARRATIVE Therapeutic hypothermia (lowering of body temperature), administered according to protocols (duration, temperature) has recently been found to improve neurological outcomes in neonates who have suffered a period of asphyxia (brain oxygen deprivation) although responses are variable. This research proposal asks in a rodent model if, during therapeutic hypothermia, NMR spectroscopy measurements of ensembles of brain metabolites can be used to assess neurologic outcome and injury, and individually guide each neonate's medical management, rather than manage according to a protocol.",34767,SAT,"Surgery, Anesthesiology and Trauma Study Section",,22,358376,
7792195,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM035978-24,,NIGMS:331446;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OKLAHOMA CITY,UNITED STATES,BIOCHEMISTRY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"WEIGEL, PAUL H;",1880139;,5R01GM035978,01/01/1986,01/31/2013,"2-Amino-2-Deoxyglucose; ABC Transport Protein; ABC Transporter Protein; ABC Transporters; ATP-Binding Cassette Transporters; Abbreviations; Address; Affinity; Amino Acids; Anabolism; Antibodies; Arthritis; Assay; Autoregulation; B-Cell Chronic Lymphocytic Leukemia Associated Oncogene; B-cell Leukemia 1; BCL; BCL1 Oncogene; Bacteria; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological; Biological Assay; Birth Defects; Body Tissues; Bovine Species; CAPS; CD44 Adhesion Receptor; CD44 Antigens; CD44 molecule; Cancer of Prostate; Cancers; Capsules; Cardiolipins; Cascade Blue; Cattle; Cell surface; Cell-Extracellular Matrix; Cells; Chitin; Chromatography, Molecular Sieve; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cytosol; D-Glucose, 2-amino-2-deoxy-; Data; Dependence; Detergents; Development; Disease; Disorder; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Screening; Duran-Reynals Permeability Factor; E coli; ECM; Electromagnetic, Laser; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Escherichia coli; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Extracellular Matrix; Family; Fibroblasts; Fluorescence; Fluorescent Probes; GL Enzyme; Glucosamine; Glucuronic Acids; Glycohydrolases; Glycosidases; Glycoside Hydrolases; Goals; HUTCH-1; Health; Hermes Antigen; Homeostasis; Human; Human, General; Hyaglosidase; Hyaluronan; Hyaluronan-Binding Protein; Hyaluronate 4-glycanohydrolase; Hyaluronate Hydrolase; Hyaluronic Acid; Hyaluronic Acid Binding Protein; Hyaluronidase; Hyaluronoglucosaminidase; In Vitro; Inflammatory Response; Insecta; Insects; Intervention; Intervention Strategies; Invertebrates, Insects; Isoenzymes; Isozymes; Label; Lasers; Life; Ligand Binding Protein; Lipids; Liposomal; Liposomes; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Mining; Minings; Modeling; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Molecular Sieve Chromatography; Monitor; Multi-Drug Resistance; Multidrug Resistance; Neoplasm Metastasis; Oligosaccharides; Pasteurella multocida; Pathogenesis; Phosphatides; Phosphatidylserines; Phospholipids; Photometry/Spectrum Analysis, Mass; Physiological Homeostasis; Pore Proteins; Preclinical Drug Evaluation; Principal Investigator; Probes, Fluorescent; Process; Prostate CA; Prostate Cancer; Prostatic Cancer; Proteins; Proteins, Pore; Proteomics; Radiation, Laser; Radio; Receptors, Hyaluronan; Regulation; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; S. pyogenes; S.pyogenes; Scintillation Counting; Secondary Neoplasm; Secondary Tumor; Serine Phosphoglycerides; Side; Size Exclusion Chromatography; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Strepavidin; Streptavidin; Streptococcus; Streptococcus Group A; Streptococcus pyogenes; Structure; Surface; System; System, LOINC Axis 4; Techniques; Testing; Time; Tissues; Translations; Tumor Cell Migration; Variant; Variation; Wound Healing; Wound Repair; aminoacid; angiogenesis; arthritic; base; beta-D-Glucopyranoside, dodecyl 4-O-alpha-D-glucopyranosyl-; biosynthesis; bovid; bovine; cancer cell; cancer metastasis; capsule (pharmacologic); cell behavior; chondroitinase; clinical applicability; clinical application; cow; dalton; disease/disorder; dodecyl maltoside; drug candidate; gene product; gp85; hasA enzyme; hyaluronan synthase; hyaluronan synthase 1; hyaluronan synthetase; hyaluronate synthase; hyaluronate synthetase; hyaluronic acid synthetase; in vivo; inhibitor; inhibitor/antagonist; instrument; interventional strategy; lauryl maltoside; light scattering; malignancy; membrane structure; multi-drug resistant; multidrug resistant; mutant; neoplasm/cancer; novel; octyl glucoside; octylglucopyranoside; octylglucoside; proteoliposomes; public health relevance; sugar; synthetic peptide; tissue repair",STRUCTURE AND FUNCTION OF HYALURONAN SYNTHASES," 4.4.7. PROJECT NARRATIVE. Many diseases, including birth defects, arthritis, ulcerating wounds, and some cancers may arise from, or be promoted by, altered synthesis of hyaluronan (HA) in the body. HA is synthesized by HA synthases, which were first cloned under this project by the PI. Knowing details about how the three human HA synthases function will enable us and others to develop strategies to identify modulators and inhibitors of these enzymes (e.g. to alter HA activity, HA size or cellular localization) that might be drug candidates for clinical applications, particularly in cancer, metastasis, and streptococcal diseases.",35978,ICI,Intercellular Interactions,,24,331446,
7761308,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM036278-26,,NIGMS:460249;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"GROSS, CAROL ANNE;",1881963;,5R01GM036278,01/01/1999,01/31/2013,"Abscission; Accounting; Address; Animal Model; Animal Models and Related Studies; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Arm; Autoregulation; Bacteria; Binding; Binding (Molecular Function); Biomass; Biotechnology; C-terminal; Cell Communication and Signaling; Cell Signaling; Cells; Chaperone; Cleaved cell; Collaborations; Communication; Coupled; Coupling; Cytoplasmic Protein; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Disease; Disorder; Drug Metabolic Detoxication; E coli; EC 2.7.7.6; Ecologic Systems; Ecosystem; Environment; Escherichia coli; Esteroproteases; Excision; Extirpation; Feedback; Funding; Future; GTP Phosphohydrolases; GTPases; Generalized Growth; Genomics; Goals; Grant; Growth; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Homeostasis; In Vitro; Intracellular Communication and Signaling; Length; Life; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Microbe; Minerals; Miscellaneous Antibiotic; Modeling; Molecular Chaperones; Molecular Interaction; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Organism; Pathogenesis; Pathway interactions; Peptidases; Peptide Hydrolases; Peptides; Peripheral; Periplasmic Space; Physiological Homeostasis; Play; Process; Production; Progress Reports; Prokaryotae; Prokaryotic Cells; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Publishing; RNA Polymerases; Reaction; Receptor Protein; Recycling; Regulation; Regulatory Pathway; Regulon; Removal; Reports, Progress; Role; SRP; Signal Recognition Particle; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Stress; Surface Proteins; Surgical Removal; System; System, LOINC Axis 4; Systems, Ecological; Testing; Time; Tissue Growth; Upper arm; Virulence; Work; base; biological adaptation to stress; biological signal transduction; cell envelope; cleaved; combat; design; designing; detoxification; disease/disorder; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; in vivo; living system; membrane structure; model organism; ontogeny; pathway; periplasm; periplasmic; pore forming protein; porin; prevent; preventing; prokaryote; public health relevance; reaction; crisis; receptor; reconstitute; reconstitution; research study; resection; response; social role; stress response; stress; reaction; thermal stress; thermo stress",Regulation of the Heat Shock Response in E. Coli," Project relevance Microbes account for fully half of the world's biomass and are of immense importance to life on earth, for reasons as diverse as performing mineral recycling in our ecosystem, making products of important for biotechnology and detoxification of the environment, and causing disease. In the last decade, the genomic sequences of 444 bacteria have been published and hundreds more are in progress. It is impossible to study all of these bacteria, but we can perform an intensive study of selected bacteria, as the paradigms we develop are widely applicable to all bacteria. We study the regulation and function of two critical responses to stress, in the model organism E. coli, where cutting edge studies are possible. These responses are highly conserved, and both have been implicated in pathogenesis in related organisms. Moreover, one of the strategies we are defining is proving to be a paradigm for responses that orchestrate production of antibiotics, virulence and agents important in environmental cleanup. Finally, our studies may uncover new targets for antibiotics.",36278,ZRG1,Special Emphasis Panel,,26,460249,
7756665,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM036452-25,,NIGMS:602328;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,BIOCHEMISTRY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"MOFFAT, JOHN KEITH;",1867312;,5R01GM036452,09/01/1990,12/30/2012,"ATP[{..}]protein-tyrosine O-phosphotransferase; Absorption; Address; Arabidopsis thaliana; Architecture; Bacillus subtilis; Bacteria; Behavior; Binding; Binding (Molecular Function); Biological; Biological Function; Biological Process; Cancers; Catalysis; Cell Communication and Signaling; Cell Signaling; Chemicals; Chemoreceptors; Chicago; Collaborations; Coupling; Cress, Mouse-ear; Crystallization; Crystallographies; Crystallography; DNA Binding; DNA Binding Interaction; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Electronics; Engineering / Architecture; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Esteroproteases; Event; Exhibits; GTP Phosphohydrolases; GTPases; Goals; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HEK3; Intracellular Communication and Signaling; Kinetic; Kinetics; Knowledge; Life; Ligand Binding; Light; Light Activity; Light Exercise; Link; Malignant Neoplasms; Malignant Tumor; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Mouse-ear Cress; Mutagenesis, Site-Directed; O element; O2 element; Oats; Organism; Output; Oxygen; P. aeruginosa; P.aeruginosa; PTK; Pathway interactions; Peptidases; Peptide Hydrolases; Photons; Photoradiation; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Plants; Plants, General; Process; Process of absorption; Progress Reports; Proteases; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteinases; Proteins; Proteolytic Enzymes; Pseudomonas aeruginosa; Pseudomonas pyocyanea; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Reports, Progress; Resolution; Rhodopseudomonas; Roentgen Rays; Serine Kinase; Serine-Threonine Kinases; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Solutions; Structural Biologist; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Techniques; Testing; Thermodynamic; Thermodynamics; Threonine Kinase; Time; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; V (voltage); Visual Receptor; X-Radiation; X-Rays; Xrays; absorption; base; biological signal transduction; biological systems; chemical kinetics; chemical reaction; chromophore; design; design and construction; designing; experiment; experimental research; experimental study; fungus; gene product; guanosinetriphosphatase; histidine kinase; hydroxyaryl protein kinase; interest; kinetics (chemistry); living system; malignancy; neoplasm/cancer; novel; pathway; protein-histidine kinase; public health relevance; research study; sensor; success; tool; tyrosyl protein kinase; voltage",Time-Resolved Macromolecular Crystallography," PROJECT NARRATIVE  Many cancers are associated with derangement of signal transduction pathways, driven by ligand binding to chemoreceptors. The pathways may be known but the mechanisms at the molecular level are not. The natural and artificial photoreceptors whose molecular mechanisms we study have parallels to, but also key differences from, chemoreceptors: the thermodynamic and structural principles of signal transduction are likely to be similar in both.",36452,MSFC,Macromolecular Structure and Function C Study Section,,25,602328,
7742644,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM037657-19,,NIGMS:221265;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,CHEMISTRY,18,036837920,US,TX,772045037,UNIVERSITY OF HOUSTON,"PETTITT, BERNARD MONTGOMERY;",1900624;,5R01GM037657,08/01/1988,12/31/2010,"Address; Affect; Area; Biochemical; Biological; Biology; Cell model; Cells; Cellular model; Collaborations; Complication; Crowding; Crystallization; Data; Development; Disease; Disorder; Electrolytes; Entropy; Free Energy; Goals; Humulin R; Hydrogen Oxide; Hydrophobic Interactions; Hydrophobic Surfaces; Hydrostatic Pressure; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Interactions, Hydrophobic; Investigation; Investigators; Methods; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Nature; Novolin R; Osmotic Pressure; Planning Theory; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Psychologic Technics; Psychologic Techniques; Psychological Techniques; Research Personnel; Researchers; Salts; Serratia; Simulate; Solutions; Solvents; Spottings; Structure; Surface; System; System, LOINC Axis 4; Technics, Psychological; Temperature; Testing; Theoretical Technics; Theoretical Techniques; Theory, Planning; Thermodynamic; Thermodynamics; Water; base; computational studies; computer studies; conformation; conformational state; dimer; disease/disorder; driving force; endonuclease; enthalpy; experiment; experimental research; experimental study; gene product; macromolecule; monomer; physical model; pressure; programs; research study; simulation; small molecule; theories",Protein Interfaces in Solution,,37657,MSFB,Macromolecular Structure and Function B Study Section,,19,221265,
7741751,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM037739-23,,NIGMS:517333;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRINCETON,UNITED STATES,BIOCHEMISTRY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"ROSE, MARK DAVID;",1867304;,5R01GM037739,12/01/1986,12/31/2012,"Address; Anaplastic; Animal Model; Animal Models and Related Studies; B blood cells; B-Cells; B-Lymphocytes; Behavior; Biological; Biology; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancers; Cell Cycle; Cell Cycle Completion; Cell Division Cycle; Cell Function; Cell Nucleus; Cell Process; Cell division; Cell fusion; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Complex; Couples; Coupling; Defect; Development; Diploid; Diploid Cells; Diploidy; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Endocytosis; Event; Export, Nuclear; Face; Fecundability; Fecundity; Fertility; Fertility/Fertilization; Fertilization; Fertilized Egg; Fertilized Ovums; Gametes; Gene Expression; Gene Proteins; GeneHomolog; Genes; Genetic Alteration; Genetic Change; Genetic defect; Germ Cells; Germ-Line Cells; Goals; Haploid; Haploidy; Homolog; Homologous Gene; Homologue; Human; Human, General; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Membrane; Membrane Fusion; Methods; Mitosis; Mitosis Stage; Mitotic; Mutation; Nuclear; Nuclear Envelope; Nuclear Export; Nuclear Fusion; Nuclear Inner Membrane; Nuclear Membrane; Nucleus; Organism; Ovum, Fertilized; Partner in relationship; Pathway interactions; Pheromone; Play; Process; Protein Gene Products; Proteins; Recruitment Activity; Regulation; Reproduction; Reproductive Cells; Role; S cerevisiae; Saccharomyces cerevisiae; Sex Cell; Structure of zygote; Subcellular Process; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicities; Undifferentiated; Yeast, Baker's; Yeast, Brewer's; Yeasts; Zygote; amphiphysin; base; cell biology; disease/disorder; facial; functional genomics; gene product; genome mutation; initial cell; living system; malignancy; mate; membrane structure; model organism; neoplasm/cancer; novel; pathway; premature; prevent; preventing; public health relevance; recruit; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; sexual cell; social role; yeast protein; zygote",Mechanisms of Nuclear and Cell Fusion in Yeast,"  As organisms grow and develop their cells transition from proliferation, when they are dividing, but lack specialized functions, to differentiation, when cell division stops and they acquire specialized functions. Successful development requires that cells not turn on the specialized functions while they are trying divide; one hallmark of cancer is that cells lose their specialized functions as they regain the capacity for unrestrained division. This project addresses the same problem in a model organism, baker's yeast, which carefully regulates the transition from cell division to being able to mate, using genes similar to human genes with relevance to human cell biology, fertility and disease.",37739,NDT,Nuclear Dynamics and Transport,,23,517333,
7789475,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM038323-22,,NIGMS:330659;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WEST LAFAYETTE,UNITED STATES,BIOLOGY,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"CRAMER, WILLIAM A.;",1867296;,5R01GM038323,04/01/1987,01/31/2013,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; 1,2-diacylglycerol; 2,5-Cyclohexadiene-1,4-dione, 2,3-dimethyl-5-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-, (all-E)-; 2-Hydroxy-N,N,N-trimethylethanaminium; 4-hydroxyquinoline; 4H-1-Benzopyran-4-one, 2-(4,6-dimethoxy-3,5,11-trimethyl-7,9,11-tridecatrienyl)-8-hydroxy-5,7-dimethoxy-3-methyl-; Abbreviations; Acceleration; Active Oxygen; Adrenodoxin Reductase; Algae; Algae, Blue-Green; Aminoethanols; Anabaena; Antibody Fragments; Antiviral Agents; Antiviral Drugs; Antivirals; Appearance; Bacillus subtilis; Benzodiones; Benzoquinones; Binding; Binding (Molecular Function); Binding Sites; Biological; Blue-Green Bacteria; CYP; Cardiolipins; Cells; Chlorophyll; Chloroplasts; Choline; Choline Glycerophospholipids; Choline Phosphoglycerides; Coenzyme Q; Combining Site; Complex; Computer Analysis; Computing Methodologies; Coupling; Crude Extracts; Crystallization; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cyanobacterium; Cyanophyceae; Cyanophyta; Cytochrome b(6)-f Complex; Cytochrome b6-f; Cytochrome b6f Complex; Cytochromes; DAG; DGDG; Data; Dependence; Diacylglycerols; Diglycerides; Drugs; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Electrophoresis; Esteroproteases; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethanolamines; Evolution; Extracts, Complex; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferredoxin-NADP Reductase; Ferredoxin[{..}]NADP+ oxidoreductase; Ferroprotoporphyrin; Fractionation, Electrophoretic; G Protein-Complex Receptor; G Protein-Coupled Receptor Genes; G-Protein-Coupled Receptors; GPCR; GPR; Genetics-Mutagenesis; Genome; Glycerin; Glycerol; Goals; H(+) Pump; H+ element; Harvest; Heme; Heme Group; Heme b; Human; Human, General; Hydrogen Ions; Hydroquinones; Immunoblotting; Immunoglobulin Fragments; Integral Membrane Protein; Intrinsic Membrane Protein; Iron; Iron-Sulfur Protein Reductase; Iron-Sulfur Proteins; Lecithin; Ligands; Link; Lipids; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Membrane; Membrane Proteins; Membrane-Associated Proteins; Menaquinone; Molecular Biology, Mutagenesis; Molecular Interaction; Movement; Mutagenesis; Mutagenesis, Site-Directed; NADPH-Ferredoxin Reductase; NQ-N-oxide; NQNO; Na element; Nature; Negative Beta Particle; Negatrons; Nostoc; Nutrient; Oxidation-Reduction; Oxides; Oxygen Radicals; PCR; Paramagnetic Resonance; Pathway interactions; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatides; Phosphatidylcholines; Phospholipids; Physiologic; Physiological; Plant Components; Plant Structures; Plants; Plants, General; Plastocyanin; Plastocyanine; Plastoquinone; Plastoquinone-9; Polymerase Chain Reaction; Preparation; Pro-Oxidants; Procedures; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Prosthesis; Prosthetic device; Prosthetics; Proteases; Protein Cleavage; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Proteomics; Protoheme; Protoheme IX; Proton Pump; Protons; Quinols; Quinone Compound; Quinone Reductases; Quinones; Reaction; Reactive Oxygen Species; Reactive Site; Redox; Regulation; Resolution; Rhinovirus; Role; S element; Screening procedure; Side; Single Crystal Diffraction; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium; Source; Spectroscopy, ESR; Structure; Sulfur; Surface Proteins; Survey Instrument; Surveys; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Thylakoid Membranes; Transmembrane Protein; Trees; Ubiquinone; Vitamin K 2; Vitamin K Quinone; Vitamin K2; X Ray Crystallographies; X-Ray Crystallography; Yeasts; analog; body movement; comparative genomics; computational analysis; computational methodology; computational methods; computer methods; cytochrome b6f; diacyl glyceride di Gal; diacylglycerol; digalactosyldiacylglycerol; diglyceride; dimer; drug/agent; electron paramagnetic resonance spectroscopy; electron transfer; experience; ferroheme; gene product; genome sequencing; his-PG; improved; in vivo; inhibitor; inhibitor/antagonist; insight; membrane structure; monomer; nonyl-4-hydroxyquinoline-N-oxide; novel; oxidation reduction reaction; p-Dihydroxybenzenes; para-Dihydroxybenzenes; pathway; photosystem; polyacrylamide; polypeptide; progesterone 11-hemisuccinate-(2-iodohistamine); protein structure; public health relevance; respiratory; rhomboid; screening; screenings; social role; stigmatellin; trafficking; ubiquinol",Problems in Membrane Protein Crystallography:  Hetero-Oligomeric Cytochrome b6f," Narrative Some of the biomedically relevant aspects of these studies are that they are directed toward an understanding of the detailed internal structure of the proteins that mediate all traffic, including nutrients and drugs, across biological membranes. Via the membrane, the set of energy-transducing proteins determines the level of energy and its regulation in the human cell.",38323,BBM,Biochemistry and Biophysics of Membranes Study Section,,22,330659,
7765592,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM039451-24,,NIGMS:316624;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,BIOCHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"RAGSDALE, STEPHEN W;",1902380;,5R01GM039451,08/01/1991,01/31/2012,"ACS-CODH protein; Acetates; Acetyl CoA; Acetyl Coenzyme A; Acids; Active Sites; Area; Bacteria; Binding; Binding (Molecular Function); Biochemistry; Biology; C element; C-terminal; CO dehydrogenase; CO2; Carbon; Carbon Dioxide; Carbon Monoxide; Carbon monoxide dehydrogenase; Carbonic Anhydride; Catalysis; Chemicals; Chemistry, Biological; CoA; Cobalamin; Coenzyme A; Coenzyme A, S-acetate; Competence; Complex; Corrinoids; Coupling; EC 2.1.1; Electron Transport; Environment; Enzymatic Biochemistry; Enzymes; Enzymology; Exhibits; Fostering; Freezing; Gases; H+ element; Hydrogen Ions; Ions; Iron-Sulfur Proteins; Kinetic; Kinetics; Macromolecular Structure; Metals; Methanobacteria; Methods; Methyltransferase; Microbe; Microbiology; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecular Structure; Organism; Oxidation-Reduction; POR protein; Pathway interactions; Physiologic; Physiological; Play; Property; Property, LOINC Axis 2; Proteins; Protons; Pyruvate synthase; Pyruvate synthetase; Reaction; Redox; Research Proposals; Role; Science of Microbiology; Site; Sites, Active; Staging; Structure; System; System, LOINC Axis 4; Testing; Time; Variant; Variation; Wood; Wood material; Work; acetyl coenzyme A synthase bifunctional enzyme; acetyl coenzyme A synthase-carbon monoxide dehydrogenase; adduct; analog; base; catalyst; conformation; conformational state; electron transfer; experiment; experimental research; experimental study; gene product; insight; living system; meter; methanogen; methylase; multidisciplinary; novel; oxidation; oxidation reduction reaction; pathway; protein protein interaction; protonation; pyruvate oxidoreductase; pyruvate-ferredoxin oxidoreductase; research study; social role; transmethylase; uptake",Enzymology of the reductive acetyl-CoA pathway,,39451,ZRG1,Special Emphasis Panel,,24,316624,
7761254,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM039519-24,,NIGMS:399055;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BIRMINGHAM,UNITED STATES,SURGERY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"CHAUDRY, IRSHAD H;",2423523;,5R01GM039519,02/01/1988,01/31/2013,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 4'-Nitro-3'-trifluoromethylisobutyranilide; ADRGND; ATF; Adrenal Glands; Adrenals; Affect; After Care; After-Treatment; Aftercare; Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide; Androgen Receptor; Androst-4-en-17beta-ol-3-one; Androstenedione Aromatase; Apoptotic; Aromatase; Aromatase Cytochrome P450; Arts; Bip-binding protein, Ig heavy chain; Bleeding; Blood Pressure; Blood Vessels; Blood Volume; Blood flow; Bone Marrow; C/EBP homologous protein; CHOP protein; CHOP-10 protein; CYP 19; CYP19 Protein; CYPXIX; Cardiac; Cardiac Myocytes; Cardiac Output; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cell Therapy; Cells; Common Rat Strains; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); DDIT3 protein; DNA damage-inducible transcript 3 protein; Delta4-androsten-17beta-ol-3-one; Depressed mood; Development; Diestrus; Dysfunction; Endoplasmic Reticulum; Endothelial Cells; Ergastoplasm; Estrogen Receptors; Estrogen Synthase; Estrogen Synthetase; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrus; Event; FLUT; Female; Ferricytochrome c; Ferrocytochrome c; Flutamide; Free Radicals; Functional disorder; Funding; GADD153 protein; Gastrointestinal Tract, Small Intestine; Gender; Genetic; Gonadal Steroid Hormones; HSP; Heart; Heart myocyte; Heat shock proteins; Hemorrhage; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Hormonal; Hypoxia; Hypoxic; Ig heavy chain binding protein; Ig-HC-carrier protein; Incidence; Inflammatory; Infusion; Infusion procedures; Injury; Intestines, Small; Intracellular Communication and Signaling; Kupffer Cells; Left; Limulus factor C; Liver; Liver Cells; Lung; Maintenance; Maintenances; Mammals, Rats; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Messenger RNA; Metestrus; Methods and Techniques; Methods, Other; Mitochondria; Modeling; Modification; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardium; Myocytes, Cardiac; Niftolid; Niftolide; Organ; Organ System, Cardiovascular; Organ failure; Oxygen Deficiency; P450AROM; Pathogenesis; Performance; Physiopathology; Predisposition; Production; Proestrus; Proteins; RNA, Messenger; Rat; Rattus; Recovery; Respiratory System, Lung; Resuscitation; Reticuloendothelial System, Bone Marrow; Sepsis; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Small Intestines; Staging; Stellate Sinusoidal Macrophage; Stress; Stress Proteins; Susceptibility; Techniques; Testosterone; Therapeutic Estrogen; Therapeutic Testosterone; Therapy, Cell; Trans-Testosterone; Trauma; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular, Heart; Ventricular; activating transcription factor; biological signal transduction; blood loss; bloodstream infection; body system, hepatic; cardiac muscle; cardiomyocyte; cell-based therapy; circulatory system; cytochrome c; depressed; endoplasmic reticulum stress; estrous; factor C; gene product; glucose regulated protein 78 kDa; glucose-regulated proteins; gonadal steroids; heart muscle; heart output; heat-shock protein 5; hemodynamics; horseshoe crab factor C; immunoglobulin heavy chain-binding protein; improved; liver macrophage; mRNA; male; mitochondrial; molecular chaperone BiP; molecular chaperone GRP78; novel; organ system, hepatic; pathophysiology; prevent; preventing; protein expression; public health relevance; pulmonary; pulmonary function; receptor downregulation; receptor expression; repair; repaired; response; sadness; sex steroid; small bowel; stem cell therapy; stress protein; suprarenal gland; transcription factor; transcription factor CHOP; vascular",Maintenance of Organ Function Following Injury, PROJECT RELEVANCE We will examine the mechanisms by which the use of female sex hormones after trauma will improve cell and organ functions and decrease the lethality from infectious complications. We will use state-of-the-art molecular techniques and cell-based therapy to delineate the mechanisms involved in injury pathogenesis. The funding will help to develop gender-specific therapy. Such therapy should prevent organ dysfunction after injury and reduce morbidity and mortality from subsequent sepsis in male and female trauma victims.,39519,ZRG1,Special Emphasis Panel,,24,399055,
7756622,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM041637-21,,NIGMS:467142;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,PHYSICS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"OKAMURA, MELVIN Y;",1867278;,5R01GM041637,04/01/1989,01/31/2011,"Accounting; Address; Amino Acids; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; CYP; Charge; Chemicals; Coenzyme Q; Complex; Coupled; Couples; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytochrome C-2; Cytochromes; Cytochromes c2; DNA Recombination; DNA recombination (naturally occurring); Dependence; Docking; ENDOR; EPR spectroscopy; Electromagnetic, Laser; Electron Nuclear Double Resonance; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Environment; FTIR; FTIR spectroscopy; Ferrocytochrome c2; Foundations; Fourier transform infrared spectroscopy; Freezing; Future; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Goals; Growth; H(+) Pump; H+ element; Hydrogen Bonding; Hydrogen Ions; Hydrogen Oxide; Individual; Ionic Strengths; Kinetic; Kinetics; Lasers; Light; Measurement; Measures; Membrane; Methods; Methods and Techniques; Methods, Other; Microscopic; Modeling; Modification; Molecular; Molecular Interaction; Molecular Medicine; Monitor; Mutagenesis, Site-Directed; Mutation; Negative Beta Particle; Negatrons; Optics; Paramagnetic Resonance; Pathway interactions; Photoradiation; Physiologic pulse; Position; Positioning Attribute; Process; Property; Property, LOINC Axis 2; Protein Dynamics; Proteins; Proton Pump; Protons; Pulse; Quinone Compound; Quinones; Radiation, Laser; Reaction; Recombination; Recombination, Genetic; Relaxation; Reporter; Research; Role; Single Crystal Diffraction; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Solutions; Solvents; Spectroscopy; Spectroscopy, ESR; Spectroscopy, Fourier Transform Infrared; Spectrum Analyses; Spectrum Analysis; Strengths, Ionic; Structure; Surface; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Techniques; Temperature; Testing; Tissue Growth; Ubiquinone; Water; Work; X Ray Crystallographies; X-Ray Crystallography; aminoacid; base; biological systems; cofactor; computational studies; computer studies; electron paramagnetic resonance spectroscopy; electron transfer; gene product; genome mutation; in vivo; infrared spectroscopy; membrane structure; mutant; ontogeny; pathway; photosynthetic bacteria; protonation; reaction rate; rhodoquinone; semiquinone; social role; structural biology",Electron and Proton Transfer in Reaction Centers,,41637,MSFA,Macromolecular Structure and Function A Study Section,,21,467142,
7751313,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM042336-20,,NIGMS:436923;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"BALCH, WILLIAM EDWARD;",1867454;,5R01GM042336,07/01/1990,12/31/2011,"Address; Animal Welfare; Bibliography; Biochemical; Biological; Biology; Cells; Collaborations; Collection; Complex; Country; Cryo-electron Microscopy; Cryoelectron Microscopy; Ecological impact; Electron Cryomicroscopy; Endoplasmic Reticulum; Environment; Environmental Impact; Equipment; Ergastoplasm; Ethics Committees, Research; Funding; Genome; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Jobs; Molecular; Occupations; Outcome; Physiologic; Physiological; Principal Investigator; Professional Postions; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Protocol; Protocols documentation; Reagent; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Series; Structure; VESCL; Vertebrate Animals; Vertebrates; Vesicle; Writing; abstracting; cryoEM; experiment; experimental research; experimental study; expiration; gene product; human subject; in vivo; nano particle; nanoparticle; novel; particle; programs; research study; response; self assembly; vertebrata",Assembly and Disassembly of COPII Nanocages,,42336,MBPP,Membrane Biology and Protein Processing Study Section,,20,436923,
7779945,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM042341-24,,NIGMS:359720;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"HARLAND, RICHARD M.;",1875280;,5R01GM042341,09/01/1988,01/31/2013,"Adhesions; Affect; Alternate Splicing; Alternative Splicing; Amphibia; Amphibians; Binding; Binding (Molecular Function); Biological Function; Biological Process; CAM 120/80; Cadherin-1; Causality; Cell Adhesion; Cell Communication and Signaling; Cell Signaling; Cellular Adhesion; Code; Coding System; Complement; Complement Proteins; DNA Synthesis Factor; Data; Defect; Development; Disease; Disorder; E-Cadherin; ECGF; Elements; Embryo; Embryo Development; Embryogenesis; Embryology; Embryology / Fetal Growth; Embryonic; Embryonic Development; Endothelial Cell Growth Factor; Enhancer Elements; Enhancer Elements (Genetics); Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Etiology; Event; Ewing's Family of Tumours; Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Ewing's Tumor; Ewings sarcoma; FGF; Family; Family member; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Frog; Gene Expression; Gene Expression Profile; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; HBGF; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Maps; Mediating; Mesoderm; Messenger RNA; Methods; Microinjections; Microsurgery; Modeling; Molecular; Molecular Interaction; Morphogenesis; Mutation; Neural Growth; Neuronal Growth; Oligo; Oligonucleotides; Organism; Pre-mRNA; Predisposition; Proteins; Proto-Oncogene, Signaling Factor; RNA; RNA Binding; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; Rana; Rana (genus); Regulation; Regulation of Splicing through Sam68; Relative; Relative (related person); Research; Ribonucleic Acid; Role; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway Gene; Somites; Splicing; Splicing Regulation Pathway; Structure; Susceptibility; Tet; Tetanus Helper Peptide; Tissue Differentiation; Uvomorulin; Work; Xenopus; base; biological signal transduction; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; egg; experiment; experimental research; experimental study; expression cloning; gain of function; gene expression signature; gene product; genetic enhancer element; genome mutation; human disease; insight; interest; living system; loss of function; mRNA; mRNA Precursor; member; neural patterning; neurogenesis; notch; notch protein; notch receptors; premRNA; public health relevance; research study; social role; tool; transcriptome",Gene Expression in Amphibian Development," Mapping of mutations that cause human diseases showed that many mutations are found in the conserved splicing junctions or branchpoint sequences of precursors to protein coding messenger RNAs, rather than in the protein coding sequence of the mRNA. It is therefore crucially important to understand the mechanisms that regulate the use of splicing signals, in order to understand the susceptibility to and etiology of diseases, as well as to devise therapies for such disease. This proposal will advance our understanding of splicing regulation using the model vertebrate organism, Xenopus, which affords technical advantages in manipulating splicing regulators, and studying the consequences of this manipulation.",42341,DEV1,Development - 1 Study Section,,24,359720,
7763247,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM043854-19,,NIGMS:272967;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"RYCHNOVSKY, SCOTT D.;",1866107;,5R01GM043854,04/01/1990,01/31/2012,"Antifungal Agents; Antifungal Drug; Arts; Aspergillus niger; Biological Factors; Blood Serum; Cancer cell line; Chemicals; Chinese; Chinese People; Cholest-5-en-3-ol (3beta)-; Cholesterol; Complex; Computing Methodologies; Coupling; Cyclization; Development; Diels Alder reaction; Dimerization; Evaluation; Factor, Biologic; Fungicides, Therapeutic; Goals; Grant; Health; Human; Human Cell Line; Human, General; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; LDL; Label; Laboratories; Lipoprotein LDL Receptors; Lipoproteins, LDL; Low Density Lipoprotein Receptor; Low-Density Lipoproteins; Man (Taxonomy); Man, Modern; Methods; Natural Products; Norditerpenes; Norditerpenoids; Polyenes; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dimerization; Quinone Compound; Quinones; Reaction; Reagent; Receptors, LDL; Research; Role; SCH 351448; SCH351448; Scientist; Sensitization, Immunologic; Sensitization, Immunological; Serum; Steroid Compound; Steroids; Structure; Students; Synthesis Chemistry; Synthetic Chemistry; Technology; Toxic effect; Toxicities; Training; abstracting; amphidinol 3; anti-fungal; antifungals; beta-Lipoproteins; computational methodology; computational methods; computer methods; design; designing; diene; drug candidate; drug development; enantiomer; human disease; improved; interest; lituarine C; oxidation; product development; programs; small molecule; social role; uptake",Synthesis of Oxygenated natrual Products,,43854,SBCB,Synthetic and Biological Chemistry B Study Section,,19,272967,
7764663,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM044974-18,,NIGMS:234775;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,GAINESVILLE,UNITED STATES,CHEMISTRY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"MERZ, KENNETH M;",1898780;,5R01GM044974,04/01/1991,01/31/2011,"Abbreviations; Active Sites; Address; Alkylation; Antigenic Determinants; Assay; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; C element; CAAX geranylgeranyl transferase; Cancer Treatment; Cancers; Carbon; Catalysis; Chemistry; Chemistry, Pharmaceutical; Collaborations; Complex; Coupled; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dimethylallyl-diphosphate[{..}]isopentenyl-diphosphate dimethylallyl (trans) transferase; Dimethylallyltransferase; Dimethylallyltranstransferase; Disease; Disorder; Docking; Dolichyl Phosphate Synthetase; Drug Interactions; Ensure; Enzyme Interaction; Enzymes; Epitopes; Ethers; Family; Farnesylpyrophosphate Synthetase; Free Energy; GGTase-I; Genetics-Mutagenesis; Geranylgeranyl Pyrophosphate Synthetase; Geranylgeranyl Transferase; Geranylgeranyltransferase Type I; Geranylpyrophosphate Synthetase; Goals; Human; Human, General; Hydrogen Oxide; Investigators; Ions; Knowledge; Lead; Letters; Ligands; Magnesium; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mechanics; Medicinal Chemistry; Mercaptans; Mercapto Compounds; Metalloproteins; Methods and Techniques; Methods, Other; Mg element; Mg++ element; Mind; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; Mono-S; MonoS; Mutagenesis; Nature; Nerylpyrophosphate Synthetase; Pb element; Peptides; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Play; Post-Translational Isoprenylation; Prenyltransferase; Process; Programs (PT); Programs [Publication Type]; Protein Isoprenylation; Protein Prenylation; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Relative; Relative (related person); Research Personnel; Researchers; Rest; Roentgen Rays; Role; S element; Scheme; Science of Chemistry; Sites, Active; Structure; Sulfhydryl Compounds; Sulfur; Techniques; Testing; Thiols; Translating; Translatings; Water; X-Radiation; X-Rays; Xrays; Zinc; Zn element; anticancer therapy; base; cancer therapy; clinical data repository; clinical data warehouse; computational studies; computer studies; conformation; conformational state; data repository; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; insight; language translation; magnesium ion; malignancy; metalloenzyme; mimetics; molecular dynamics; mutant; neoplasm/cancer; novel; preference; programs; protein GGTase; protein geranylgeranyltransferase; protein structure function; quantum; ras protein GG transferase; ras protein geranylgeranyltransferase; relational database; research study; simulation; small molecule; social role; structural biology; sulfhydryl group; tool",Metalloenzyme Structure and Function,,44974,ZRG1,Special Emphasis Panel,,18,234775,
7749026,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM045751-19,,NIGMS:677138;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BRONX,UNITED STATES,ANATOMY/CELL BIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"SCHILDKRAUT, CARL L;",1968970;,5R01GM045751,01/08/1992,12/31/2011,"Affect; Animal Welfare; B-Cell Development; Bibliography; Cells; Chromatin; Chromatin Structure; Chromosomal Organization; Chromosomal Structure; Chromosome Organization; Chromosome Structures; Country; DNA; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; Deoxyribonucleic Acid; Development; ES cell; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equipment; Ethics Committees, Research; Genes; Heavy-Chain Immunoglobulins; Histones; IACUC; IRBs; Immunoglobulins, Heavy-Chain; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knock-in; Knock-in Mouse; Location; Mammalian Cell; Mammals, Mice; Mice; Modification; Murine; Mus; Names; Nuclear; Phase; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Replication Initiation; Replication Origin; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Role; Site; Staging; Time; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Vertebrate Animals; Vertebrates; abstracting; chromatin modification; embryonic stem cell; expiration; gene product; histone modification; human subject; initiation site of DNA replication; new approaches; novel approaches; novel strategies; novel strategy; ori Region; programs; single molecule; social role; stem cell of embryonic origin; vertebrata",DNA Replication Initiation Sites in Mammalian Cells,,45751,MGC,Molecular Genetics C Study Section,,19,677138,
7778245,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM046454-19,,NIGMS:495528;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"SHYU, ANN-BIN ;",1891693;,5R01GM046454,07/01/1991,12/31/2012,"5'-Adenylic acid, homopolymer; Address; Affect; Affinity; Allergic; Allergic inflammation; Autoimmune Diseases; Biogenesis; Biological; Cancers; Cells; Complex; Cytoplasm; Cytoplasmic Domain; Cytoplasmic Tail; Decay, mRNA; Degradation, mRNA; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; Elements; Epithelial Cells; Funding; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Human; Human, General; In element; Indium; Individual; Inflammatory; Link; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Micro RNA; MicroRNAs; ORFs; Open Reading Frames; Origin of Life; Pathway interactions; Phase; Play; Poly A; Poly(A) Tail; Poly(A)+ mRNA Binding Protein; Poly(A)-Binding Proteins; Poly(rA); Position; Positioning Attribute; Process; Production; Protein Coding Region; Proteins; Quality Control; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA, Messenger; Regulation; Repression; Role; Route; Stability, mRNA; Staging; Testing; Therapeutic Agents; Trans-Acting Factors; Trans-Activators; Transactivators; Translations; autoimmune disorder; gene product; human disease; insight; mRNA; mRNA Decay; mRNA Stability; mRNA Transcript Degradation; mRNP; malignancy; messenger ribonucleoprotein; miRNA; neoplasm/cancer; new therapeutics; next generation therapeutics; novel therapeutics; pathway; polyadenylate; protein complex; public health relevance; response; social role; trans acting factor (genetic)",Messenger RNA Turnover in Mammalian Cells," PROJECT NARRATIVE The proposed studies will reveal fundamental principles that govern mammalian mRNA turnover and translation. Since many human diseases (e.g., cancers, autoimmune diseases, allergic inflammation, etc.) are associated with an alteration in the level of gene expression controlled by mRNA stability or translation, the proposed study has the potential to unravel new mechanisms underlying these conditions and thus facilitate the development of novel therapeutic agents.",46454,MGC,Molecular Genetics C Study Section,,19,495528,
7762715,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM046779-20,,NIGMS:422472;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,OTHER BASIC SCIENCES,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"RICHTER, JOEL D;",1862037;,5R01GM046779,02/01/1992,01/31/2012,"ATP-RNA Adenylyltransferase; ATP[{..}]polynucleotide adenylyltransferase; Animal Welfare; Bibliography; Binding; Binding (Molecular Function); Binding Proteins; Cell Nucleus; Cells; Complex; Country; Cytoplasm; Development; Dissociation; Ecological impact; Elements; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; G2/Mitotic-Specific Cyclin B1; Gene Expression; Gene Products, RNA; Generalized Growth; Growth; Hormonal; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Length; Ligand Binding Protein; Mediating; Meiosis; Messenger RNA; Molecular; Molecular Interaction; Names; Nuclear; Nuclear RNA; Nucleus; Phosphorylation; Poly A Polymerase; Poly(A) Tail; Polyadenylate Polymerase; Polyadenylate Synthetase; Polyadenylation; Polynucleotide Adenylyltransferase; Pre-mRNA; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; RNA; RNA Metabolism[{..}] Processing and Transport; RNA Polyadenylation; RNA Processing; RNA, Messenger; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA, Nuclear; RNA-Binding Proteins; RNP; Research; Research Ethics Committees; Research Resources; Resources; Riboadenylate Transferase; Ribonucleic Acid; Ribonucleoproteins; Tail; Tissue Growth; Translating; Translatings; Translational Activation; Translations; Vertebrate Animals; Vertebrates; Xenopus oocyte; abstracting; cyclin B1; experience; experiment; experimental research; experimental study; expiration; gene product; human subject; language translation; mRNA; mRNA Precursor; meiotic; ontogeny; oocyte maturation; premRNA; programs; research study; response; vertebrata",Polyadenylation and Translational Control,,46779,MGC,Molecular Genetics C Study Section,,20,422472,
7786972,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM048847-15,,NIGMS:324053;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BURLINGTON,UNITED STATES,BIOCHEMISTRY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"MORRICAL, SCOTT W;",1887196;,5R01GM048847,08/01/1993,01/31/2013,"ATP Hydrolysis; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Bacteriophage T4; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Cancer Treatment; Cancers; Cells; Chemistry, Biological; Coliphage T4; Communicable Diseases; Complex; DNA; DNA Helicases; DNA Recombination; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA recombination (naturally occurring); DNA replication fork; DNA unwinding enzyme; DNA, Single-Stranded; Defect; Deoxyribonucleic Acid; Diagnosis; Enterobacteria phage T4; Enzyme Activation; Enzymes; Exhibits; Filament; Fluorescence; Genetic Recombination; Genetics-Mutagenesis; Genome; Homologous Recombinational Repair; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Kinetic; Kinetics; Light; Link; Maintenance; Maintenances; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Miscellaneous Antibiotic; Modeling; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; Organism; Pathway interactions; Photoradiation; Polymerase; Prevention; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Public Health; Recombination; Recombination Repair; Recombination, Genetic; Recruitment Activity; Research; SS DNA BP; Sedimentation process; Single-Stranded DNA; Single-Stranded DNA-Binding Protein; Spectroscopy; Spectrum Analyses; Spectrum Analysis; System; System, LOINC Axis 4; T4 Phage; Testing; Thermodynamic; Thermodynamics; anticancer therapy; antitumor drug; cancer therapy; conformation; conformational state; cross-link; crosslink; fluorescence imaging; gene product; helicase; human disease; living system; malignancy; neoplasm/cancer; pathway; presynaptic; programs; protein protein interaction; public health medicine (field); recombinase; recombinational repair; recruit; sedimentation; single molecule; treatment strategy; tumor",Assembly and Activation of Enzyme-ssDNA Complexes," Proper assembly of enzyme-ssDNA complexes is critical for genome replication and maintenance in all organisms. Defects in enzyme-ssDNA assembly processes are implicated in cancer and other human disease states. Enzyme-ssDNA assembly pathways are also potential targets for new classes of antibiotic and antitumor drugs. Our studies of enzyme-ssDNA assembly mechanisms may therefore shed light on how tumors develop and how infectious diseases progress, and may also suggest new treatment strategies.",48847,MGA,Molecular Genetics A Study Section,,15,324053,
7742194,R01,GM,5,,12/01/2009,11/30/2010,PA-07-070,5R01GM049975-16,,NIGMS:329440;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,CHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KIESSLING, LAURA L;",2184125;,5R01GM049975,07/01/1993,11/30/2011,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affinity; Animal Welfare; Antigen Processing; Antigen Processings; Antigens; Bacteria; Bibliography; Binding; Binding (Molecular Function); Biology; CD209; CD209 gene; CDSIGN; Carbohydrates; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell surface; Cell-to-Cell Interaction; Cellular Migration; Chemicals; Country; DC-SIGN; DC-SIGN1; Dendritic Cells; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Glycopeptides; Goals; HIV; HTLV-III; Health; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; IACUC; IRBs; Image; Immune response; Immune system; Immunity; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigation; LAV-HTLV-III; Lectin; Ligands; Lymphadenopathy-Associated Virus; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Modeling; Molecular; Molecular Interaction; Motility; Motility, Cellular; Mycobacterium tuberculosis; Names; Organism; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Receptor Protein; Reporter; Research; Research Ethics Committees; Research Resources; Resources; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Structure; Variant; Variation; Veiled Cells; Vertebrate Animals; Vertebrates; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus-HIV; abstracting; antigen processing; base; biological signal transduction; body system, allergic/immunologic; cell motility; chemical synthesis; design; designing; expiration; fungus; host response; human subject; imaging; immunogen; immunoresponse; inhibitor; inhibitor/antagonist; insight; living system; novel; organ system, allergic/immunologic; pathogen; prevent; preventing; programs; receptor; small molecule; social role; tool; trafficking; uptake; vaccine effectiveness; vertebrata; virus protein",Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function,,49975,ZRG1,Special Emphasis Panel,,16,329440,
7749938,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM050224-15,,NIGMS:271127;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STONY BROOK,UNITED STATES,BIOCHEMISTRY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"CITOVSKY, VITALY H;",1901546;,5R01GM050224,01/01/1994,12/31/2010,"ATP-protein phosphotransferase; Aminoacetic Acid; Binding; Binding (Molecular Function); Body Tissues; Cells; Code; Coding System; Communication; Development; Enzymes; Esteroproteases; Glycine; Goals; Grips; Hand; Infection; Knock-out; Knockout; Molecular; Molecular Interaction; Morphogenesis; Movement; Neck; Pathway interactions; Peptidases; Peptide Hydrolases; Permeability; Phosphorylation; Phytophagineae; Plant Viruses; Plants; Plants, General; Plasmodesmata; Proteases; Protein Kinase; Protein Phosphorylation; Protein Trafficking; Proteinases; Proteins; Proteolytic Enzymes; Regulation; Regulatory Pathway; Relaxation; Research; Resistance; Role; Route; Sphincter; Staging; System; System, LOINC Axis 4; Tissues; Tobacco Mosaic Virus; Traffickings, Protein; Virus; Viruses, General; Work; body movement; callose; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; grasp; hydroxyalkyl protein kinase; intercellular connection; pathway; phosphorylase b kinase kinase; plant development; plant growth; plant growth/development; positional cloning; protein transport; research study; resistant; reverse genetics; social role; tool",Regulation of Macromolecular Transport Through Plasmodesmata,,50224,ZRG1,Special Emphasis Panel,,15,271127,
7777770,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM050351-13,,NIGMS:250767;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOMA LINDA,UNITED STATES,OTHER BASIC SCIENCES,41,009656273,US,CA,92350,LOMA LINDA UNIVERSITY,"SOWERS, LAWRENCE C;",1865175;,5R01GM050351,01/01/1994,12/31/2012,"(beta 1-(2-Deoxyribopyranosyl))thymidine; 2,4(1H,3H)-pyrimidinedione; 2,4-dioxopyrimidine; 2,4-pyrimidinediol; 2-hydroxy-4-(3H)-pyrimidione; 4-Amino-10-methylfolic Acid; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; 4-hydroxy-2-(1H)-pyrimidione; Address; Area; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Base Excision Repairs; Basic Research; Basic Science; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Buffers; Cancer Cause; Cancer Etiology; Cancers; Cell Aging; Cell Senescence; Cellular Aging; Chemicals; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Chromosomal dislocation; Chromosomal translocation; Chromosomes; Chromosomes, Human; Combination Chemotherapy Regimen; Comet Assay; Complex; DNA; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA N-glycosidase; DNA Repair; DNA Sequence; DNA Structure; DNA glycosylase; DNA repair protein; DNA-Protein Interaction; Data; Degenerative Disorder; Deoxyribonucleic Acid; Deoxyuridine; Discipline; Electrophoretic Mobility Shift Assay; Equilibrium; Event; FLR; Failure (biologic function); Fluorescence; Fluorescent Probes; Free Radicals; G-Quadruplex; G-Quadruplexes DNA; G-Quartet Structures; G-Quartets; G-Tetrads; G4-DNA; Gel Electrophoresis, Single-Cell; Genetic Alteration; Genetic Change; Genetic defect; Genome Instability; Genomic Instability; Human; Human Chromosomes; Human, General; Hydrolysis; In Vitro; Incubated; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-; Laboratories; Lead; Lesion; Life; Ligand Binding Protein; Ligase; Location; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Methotrexate; Methotrexate Methylaminopterin; Methotrexatum; Methylation; Metotrexato; Mobility Shift Assay; Molecular Interaction; Monitor; Mutation; Normal Cell; Nucleic Acid Probes; Oligo; Oligonucleotides; Organism; PIN2; Pathway interactions; Pb element; Physiologic; Physiological; Position; Positioning Attribute; Probes, Fluorescent; Protein Methylation; Proteins; Publishing; Quimioterapia; Relaxation; Repairs, Base Excision; Senescence, Cellular; Senescence, Replicative; Series; Site; Solutions; Structure; Synthetases; TEBP; TERF1; TERF1 gene; TRBF1; TRF1; Telomere End-Binding Protein; Telomere Maintenance; Telomere Repeat Binding Factor; Telomere Repeat Binding Proteins; Telomere-Binding Proteins; Temperature; Translocation, Genetic; Unscheduled DNA Synthesis; Uracil; Uridine, 2'-deoxy-; Work; balance; balance function; base; cancer chemotherapy; chemotherapy; chromosome dislocation; chromosome replication; chromosome translocation; degenerative condition; degenerative disease; failure; forging; gel shift assay; gene product; genome mutation; hTRF1-AS; heavy metal Pb; heavy metal lead; human DNA; innovate; innovation; innovative; insight; living system; malignancy; neoplasm/cancer; nuclease; oxidation; pathway; prevent; preventing; protein complex; protein function; public health relevance; repair; repaired; telomere; tumor",Hydrolytic and Free Radical Mediated DNA Damage," Human DNA is persistently damaged and must be repaired to prevent degenerative diseases and cancer. The DNA at the ends of human chromosomes is contained in structures called telomeres, and currently, very little is known about the consequences of telomere damage and how telomeres are repaired. The studies proposed here will lead to a better understanding of cancer etiology and suggest new strategies for cancer chemotherapy.",50351,CE,Cancer Etiology Study Section,,13,250767,
7751208,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM050781-18,,NIGMS:261193;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"BOROVIK, A. S.;",1902313;,5R01GM050781,04/01/1994,12/31/2011,"Active Sites; Animal Welfare; Applications Grants; Architecture; Arm; Bibliography; Book Chapters; Chapters, Book; Complex; Country; Ecological impact; Engineering / Architecture; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Future; Goals; Grant Proposals; Grants, Applications; Hydrogen Bonding; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Ions; Left; Ligands; Manuscripts; Metalloproteins; Metals; Molecular; Paper; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publishing; Reaction; Research; Research Ethics Committees; Research Resources; Resources; Sites, Active; Structure; System; System, LOINC Axis 4; Upper arm; Vertebrate Animals; Vertebrates; Work; abstracting; design; designing; expiration; human subject; oxidation; programs; response; vertebrata",Hydrogen Bonding Cavity Motifs About Metal Ions,,50781,MSFA,Macromolecular Structure and Function A Study Section,,18,261193,
7741248,R01,GM,5,,12/01/2009,11/30/2010,PA-07-070,5R01GM051968-13,,NIGMS:359873;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,PHARMACOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"ANDERSON, RICHARD A.;",6232800;,5R01GM051968,12/01/1994,11/30/2012,"1,2-diacylglycerol; 1-Phosphatidylinositol 3-Kinase; 5'-Adenylic acid, homopolymer; APOE [{C0003595}]; ATP-RNA Adenylyltransferase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; ATP[{..}]polynucleotide adenylyltransferase; Amino Acid Sequence; Apo-E; ApoE; Apolipoprotein E; Apoplexy; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Cancer Treatment; Cardiovascular Diseases; Cell Communication and Signaling; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chiro-Inositol; Chromatin; Code; Coding System; Complex; Cytoplasmic Granules; DAG; DHQU; DIA4; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; DT-diaphorase; DTD; Data; Diacylglycerols; Diaphorase (NADH/NADPH); Diaphorase-4; Diglycerides; EC 2.7; Elements; Enzymes; Eukaryote; Eukaryotic Cell; Gene Expression; Gene Products, RNA; Gene Proteins; Gene Targeting; Generations; Genes; Goals; HO-1 enzyme; HO1; HO2; HSP32; Haem Oxygenase; Head; Health; Heme Oxygenase (Decyclizing); Heme,hydrogen-donor[{..}]oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating); Holoenzymes; Human; Human, General; Hydrolysis; Hydroxyl; Hydroxyl Radical; Immune Precipitation; Immunoprecipitation; In Vitro; Inositide Phospholipids; Inositol; Inositol Phosphoglycerides; Inositol Phospholipids; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messengers; Isoforms; Kinases; Lipids; METBL; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Membrane; Menadione Reductase; Mesoinositol; Messenger RNA; Metabolic Processes; Metabolism; Microarray Analysis; Microarray-Based Analysis; NAD(P)H Dehydrogenase (Quinone) 1; NAD(P)H dehydrogenase (quinone) 1, human; NAD(P)H[{..}]Quinone Oxidoreductase; NADPH[{..}]Quinone Reductase; NMOR1; NMORI; NQO1; NQO1 gene; NQO1 protein; NQO1 protein, human; Names; Nerve Degeneration; Neuron Degeneration; Nuclear; Nuclear Protein; Nuclear Proteins; Nucleus; Organism; Oxidative Stress; Oxidative Stress Induced Gene Expression Via Nrf2; Oxidative Stress Pathway; PI-3 Kinase; PI-3K; PI3-Kinase; PIP2; PTDINS5P; Pathway interactions; Phosphatases; Phosphatidyl Inositol; Phosphatidyl Inositol Phosphates; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Phylloquinone Reductase; Play; Pneumology; Pneumonology; Pol II; Poly A; Poly A Polymerase; Poly(A) Tail; Poly(A)+ mRNA; Poly(rA); Polyadenylate Polymerase; Polyadenylate Synthetase; Polyadenylated mRNA; Polyadenylation; Polyadenylation Pathway; Polyadenylation of mRNA; Polynucleotide Adenylyltransferase; Polyphosphoinositides; Position; Positioning Attribute; Pre-mRNA; Process; Production; Protein Gene Products; Protein Isoforms; Protein Structure, Primary; Proteins; PtIns 4,5-P2; PtdIns; PtdIns 3-Kinase; PtdIns-5-P; PtdInsP2; Pulmonary Disease (Specialty); Pulmonary Medicine; Pulmonology; QR1; Quinone Oxidoreductase; RNA; RNA 3' End Processing; RNA Polyadenylation; RNA Sequences; RNA, Messenger; RNA, Messenger, Polyadenylated; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA, Small Interfering; Regulation; Riboadenylate Transferase; Ribonucleic Acid; Role; Screening procedure; Second Messenger Systems; Second Messengers; Sequences, RNA; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stream; Stroke; Structure; Subcellular Process; Substrate Specificity; Tail; Targetings, Gene; Testing; Transcript; Transduction Gene; Transphosphorylases; Transplantation; Two Hybrid; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Vascular Accident, Brain; Vector Mediated Transfer Genes; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; Zeta-Crystallin; anticancer therapy; biological adaptation to stress; biological signal transduction; brain attack; cancer therapy; cardiovascular disorder; cerebral vascular accident; cross-link; crosslink; diacylglycerol; diaphorase 4, human; diglyceride; eukaryotida; gene product; granule; heme oxygenase-1; hemeoxygenase 1; human disease; in vivo; interest; living system; mRNA; mRNA Expression; mRNA Precursor; member; membrane structure; microarray technology; neural degeneration; neurodegeneration; neuronal degeneration; novel; pathway; phosphatidylinositol 5-phosphate; polyadenosine; polyadenylate; polyriboadenosine; premRNA; protein protein interaction; protein sequence; public health relevance; quinone reductase 1, human; reaction; crisis; response; screening; screenings; second messenger; siRNA; social role; stress response; stress; reaction; stroke; transplant; yeast two hybrid system",Phosphoinositide Signaling To and Within the Nucleus," The expression of cellular proteins from genes occurs through messenger RNAs (mRNAs) made by each gene and this requires that the mRNA have a polyadenosine tail. This tail is required before the mRNA can make cellular proteins. We have discovered a new enzyme that uniquely makes these tails and this enzyme works to generate mRNAs and the encoded proteins. Most interesting and paradigm shifting is the fact that this process is regulated by a lipid messenger called phosphatidylinositol-4,5-bisphosphate. The genes whose expression this novel pathway controls are heme oxygenase-1 (HO-1), apolipoprotein E (APOE) and NAD(P)H:quinone oxidoreductase (NQO1). The control of these genes has dramatic implications for many aspects of human health including cardiovascular disease, transplantation, neurodegeneration, cancer therapy, and pulmonary medicine.",51968,NDT,Nuclear Dynamics and Transport,,13,359873,
7754674,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM051986-16,,NIGMS:367660;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLOOMINGTON,UNITED STATES,BIOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"BRUN, YVES V;",1968543;,5R01GM051986,01/01/1995,12/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Bacteria; Biological Models; Bypass; Caulobacter; Caulobacter crescentus; Cell Communication and Signaling; Cell Cycle; Cell Differentiation; Cell Differentiation process; Cell Division Cycle; Cell Function; Cell Process; Cell Shape; Cell Signaling; Cell division; Cell physiology; Cells; Cellular Function; Cellular Morphology; Cellular Physiology; Cellular Process; Complex; DNA Replication; DNA Synthesis; DNA biosynthesis; Defect; Development; Electrons; Environment; Epistasis; Epistasis, Genetic; Epistatic Deviation; Flagella; Generalized Growth; Generations; Genes; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Epistasis; Genetic defect; Genomics; Goals; Growth; Infection; Interaction Deviation; Intracellular Communication and Signaling; Length; Life Cycle; Life Cycle Stages; Methods; Model System; Modeling; Models, Biologic; Molecular; Morphogenesis; Morphology; Mutation; Negative Beta Particle; Negatrons; Nutrient; Organelles; Output; Pathogenicity Factors; Pathway interactions; Physiology; Pilum; Process; Programs (PT); Programs [Publication Type]; Proteins; Proteomics; Public Health; Regulation; Regulator Genes; Regulatory Pathway; Research; Role; Rotation; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Site; Staging; Structure; Subcellular Process; Time; Tissue Growth; Transcriptional Regulatory Elements; Virulence Factors; biological signal transduction; cell envelope; cell morphology; cell type; design; designing; fimbriae; gene function; gene product; gene x gene interaction; genetic epistases; genome mutation; improved; insight; life course; model organism; mutant; ontogeny; pathogen; pathogenic bacteria; pathway; pilus; programs; public health medicine (field); public health relevance; regulatory gene; response; social role; trans acting element; uptake",Global control of differentiation in Caulobacter,,51986,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,16,367660,
7645698,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM053640-15,,NIGMS:329918;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATLANTA,UNITED STATES,CHEMISTRY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"DYER, RICHARD BRIAN;",1895264;,5R01GM053640,06/01/1996,12/31/2012,"Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acid Sequence; Behavior; Biological Models; Biology; Characteristics; Collaborations; Coupled; Coupling; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Deposit; Deposition; Development; Disease; Disorder; Electromagnetic, Laser; Equilibrium; Event; Exhibits; Experimental Designs; Fluorescence; Foundations; Free Energy; Grant; Homeo Domain; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Isotopes; Kinetic; Kinetics; Label; Lasers; Length; Lewy Body Parkinson Disease; Literature; Methods; Methods and Techniques; Methods, Other; Microscopic; Model System; Modeling; Models, Biologic; Molecular; Molecular Dynamics Simulation; Motor Neuron Disease; N-terminal; NH2-terminal; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Peptide Domain; Peptides; Point Mutation; Primary Parkinsonism; Primary Senile Degenerative Dementia; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion-Induced Disorder; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Protein Domains; Protein Structure, Primary; Proteins; Radiation, Laser; Reaction; Relaxation; Relaxation Technics; Relaxation Techniques; Residual; Residual state; Resolution; Role; S-1; S-1 Antimetabolite agent; Simulate; Site; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Speed; Speed (motion); Spongiform Encephalopathies, Transmissible; Structure; System; System, LOINC Axis 4; Techniques; Tertiary Protein Structure; Testing; Time; Transmissible Dementias; Work; aberrant protein folding; abnormal protein folding; balance; balance function; dementia of the Alzheimer type; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; homeodomain; improved; interest; molecular dynamics; neurodegenerative illness; new approaches; novel approaches; novel strategies; novel strategy; pathologic protein folding; pathway; primary degenerative dementia; protein complex; protein folding; protein mis-folding; protein misfolding; protein sequence; protein structure prediction; public health relevance; research study; ribosomal protein L9; senile dementia of the Alzheimer type; simulation; social role; spongiform degeneration; spongiform encephalopathy; theories; villin",Early Events in Protein Folding,,53640,MSFB,Macromolecular Structure and Function B Study Section,,15,329918,
7756661,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM053804-15,,NIGMS:357847;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,ANATOMY/CELL BIOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"VILLENEUVE, ANNE M;",1932402;,5R01GM053804,02/08/1996,01/13/2013,"Anaphase; Aneuploid; Aneuploidy; Animals; Architecture; Behavior; Biochemical; Birth Defects; C elegans; C.elegans; Caenorhabditis elegans; Cell division; Centrosome; Chiasma; Chiasma Opticum; Chromosomal Organization; Chromosomal Structure; Chromosome Organization; Chromosome Pairing; Chromosome Segregation; Chromosome Structures; Chromosomes; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA Recombination; DNA recombination (naturally occurring); Development; Diploid; Diploidy; Engineering / Architecture; Ensure; Event; FLR; Failure (biologic function); Family; Female; Gametes; GeneHomolog; Genetic; Genetic Recombination; Genetic Screening; Genomics; Germ Cells; Germ-Line Cells; Goals; Haploid; Haploidy; Health; Homolog; Homologous Gene; Homologue; Human; Human, General; Image; Imagery; Kinesin; Label; Length; Life; Link; Man (Taxonomy); Man, Modern; Meiosis; Miscarriage; Mitotic Anaphase; Modeling; Molecular; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Movement; Nematoda; Nematodes; Nuclear; Nucleotides; Oocytes; Optic Chiasm; Optic Chiasma; Optic Chiasmas; Optic Decussation; Organism; Ovocytes; Pachynema; Pachytene Stage; Phase; Population; Preparation; Process; Property; Property, LOINC Axis 2; Prophase; Proteins; Racial Segregation; Recombination; Recombination, Genetic; Reproductive Cells; Research; Resolution; Role; Sex Cell; Spontaneous abortion; Structure; Synapsis; Synapsis, Chromosomal; Synaptonemal Complex; System; System, LOINC Axis 4; Testing; Time; Visualization; Work; X Chromosome; advanced maternal age; advanced reproductive age; base; body movement; cancer progression; chromokinesin; experiment; experimental research; experimental study; failure; gene product; imaging; imaging modality; initial cell; living system; meiotic; mutant; neoplasm progression; neoplastic progression; new approaches; novel; novel approaches; novel strategies; novel strategy; public health relevance; research study; roundworm; segregation; sexual cell; social role; tumor progression",Meiotic Chromosome Segregation in C. elegans," Project Narrative: The proposed research will increase our understanding of the basic mechanisms that promote and ensure the faithful inheritance of chromosomes. The work is highly relevant to human health, as errors in chromosome inheritance are one of the leading causes of miscarriages and birth defects and are also a major factor contributing to the development and progression of cancer. Several components of the plan are highly relevant to understanding how features of chromosome organization contribute to assembly and function of the female meiotic spindle, a process that becomes increasingly error-prone with advanced maternal age.",53804,MGC,Molecular Genetics C Study Section,,15,357847,
7749057,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM054397-47,,NIGMS:705829;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"RICHARDSON, CHARLES C.;",1968264;,5R01GM054397,01/01/1976,12/31/2011,"ATP[{..}]uridine 5'-phosphotransferase; Animal Welfare; Bacteriophage T7; Bacteriophages; Bibliography; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; C-terminal; Coliphage T7; Complex; Country; Cytidine Kinase; DNA; DNA Helicases; DNA Polymerases; DNA Primase; DNA Replication; DNA Synthesis; DNA Unwinding Proteins; DNA biosynthesis; DNA replication fork; DNA unwinding enzyme; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Dideoxynucleosides; Docking; E coli; EC 2.7.7.7; Ecological impact; Enterobacteria phage T7; Environment; Environmental Impact; Equipment; Escherichia coli; Ethics Committees, Research; Generalized Growth; Genes; Genetic; Goals; Growth; Helicase Gene; Hydrolysis; IACUC; IRBs; Imagery; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; L-Phenylalanine; Ligand Binding Protein; Methods; Methods and Techniques; Methods, Other; Molecular Interaction; Movement; Names; Okazaki fragments; Phages; Phenylalanine; Phenylalanine, L-Isomer; Play; Polymerase; Postdoc; Postdoctoral Fellow; Primase; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; Reaction; Research; Research Associate; Research Design; Research Ethics Committees; Research Resources; Resources; Role; Site; Solutions; Specificity; Structure; Study Type; System; System, LOINC Axis 4; T7 Phage; Tail; Techniques; Thioredoxin; Thumb; Thumb structure; Tissue Growth; Uridine Kinase; Uridine-Cytidine Kinase; Vertebrate Animals; Vertebrates; Visualization; Zinc; Zn element; abstracting; bacterial virus; base; body movement; ddNus; experiment; experimental research; experimental study; expiration; gene product; helicase; human subject; ontogeny; post-doc; post-doctoral; programs; reconstitute; reconstitution; research study; single molecule; social role; study design; vertebrata",Structure and Synthesis of DNA,,54397,MGA,Molecular Genetics A Study Section,,47,705829,
7749968,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM054657-13,,NIGMS:324530;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"CHISHOLM, ANDREW D;",1968227;,5R01GM054657,05/01/1997,12/31/2010,"Accounting; Address; Adhesions; Adhesives; Affect; Anchors, Glycosylphosphatidylinositol; Artificial Organs; Biochemical; Birth Defects; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Candidate Disease Gene; Candidate Gene; Cell Adhesion; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cell surface; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Cellular Migration; Complex; Confocal Microscopy; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Core Protein; Cytoplasmic Membrane; DISSEC; Data; Development; Developmental Biology; Disease Pathway; Dissection; EC 2.7; EPH; Electromagnetic, Laser; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Enhancers; Eph Family Receptors; Eph Receptor Ligands; Eph Receptor Tyrosine Kinase; Eph Receptors; Ephrin Receptors; Ephrins; Epidermis; G-Protein alpha Subunit; G-Proteins; GPI; GPI Membrane Anchors; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; GTP-Regulatory Proteins; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Models; Genetic analyses; Genetic defect; Genetics, Human; Gly-PtdIns; Glycoinositol Phospholipid Membrane Anchor; Glycosyl-Phosphatidylinositol; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Glycosylated Phosphatidylinositols; Glycosylphosphatidylinositols; Glypican; Growth Cones; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HSPG; Heparan Sulfate; Heparan Sulfate Proteoglycan; Heparitin Sulfate; Hereditary Disease; Human; Human Genetics; Human, General; Idiopathic Hypogonadotropic Hypogonadism; Immigrations; In-Migration; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Kallmann Syndrome; Kallmann-de Morsier syndrome; Kinases; Label; Lasers; Ligands; Light; Link; Maestre de San Juan-Kallmann-de Morsier syndrome; Maestre-Kallmann-de Morsier syndrome; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mastre de San Juan-Kallmann syndrome; Mediating; Microscopy, Confocal; Microsurgery; Modeling; Models, Genetic; Molecular; Molecular Disease; Molecular Genetic Abnormality; Morphogenesis; Morphology; Motility; Motility, Cellular; Movement; Mutation; Nature; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Neural Cell; Neural Stem Cell; Neural Tube Closure; Neurocyte; Neurons; Organ; Organogenesis; Ortholog; Orthologous Gene; Palate; Pathway interactions; Pharmacology; Phenotype; Phosphotransferases; Photoradiation; Plasma Membrane; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Subunits; Proteins; Proteoheparan Sulfate; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation, Laser; Receptor Protein; Receptor Signaling; Receptors, Eph Family; Regulatory Pathway; Research Personnel; Researchers; Resolution; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Study models; Testing; Tissue Model; Tissues; Transphosphorylases; Work; Wound Healing; Wound Repair; axon growth cone guidance; axon guidance; base; biological signal transduction; body movement; cell motility; congenital anosmia-hypogonadotropic hypogonadism syndrome; de Morsier syndrome; de Morsier-Gauthier syndrome; driving force; experiment; experimental research; experimental study; familial hypogonadism with anosmia; gene product; genetic analysis; genetic disorder; genome mutation; hereditary disorder; human disease; hypogonadism-anosmia syndrome; hypogonadotropic hypogonadism-anosmia (HHA) syndrome; hypogonadotropic hypogonadism-anosmia syndrome; hyposmia-hypogonadotropic hypogonadism syndrome; idiopathic hypothalamic hypogonadism; idiopathic hypothalamic hypogonadism (IHH); interventional strategy; malignancy; migration; mutant; neoplasm/cancer; nerve stem cell; neural progenitor cells; neuroblast; neuronal; neuronal progenitor; neuronal progenitor cells; olfacto-ethmoidodypothalamic dysraphia; olfacto-ethmoidohypothalamic dysplasia; olfactogenital dysplasia; olfactogenital syndrome; pathway; plasmalemma; programs; receptor; research study; roundworm; social role; stem cell niche; syndecan; tissue repair; tumor",Mechanisms of Tissue Morphogenesis in C. elegans,,54657,DEV1,Development - 1 Study Section,,13,324530,
7754120,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM055040-11,,NIGMS:251145;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LIM, WENDELL A;",1932407;,5R01GM055040,01/01/1997,12/31/2011,"Animal Welfare; Bibliography; Biochemical; Cell Communication and Signaling; Cell Signaling; Cells; Chemicals; Complex; Country; Cues; EC 2.7.2-; Ecological impact; Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Eukaryote; Eukaryotic Cell; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; Goals; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Kinetic; Kinetics; MAP Kinase Gene; MAP Kinase Kinases; MAP kinase; MAPK; MAPK Kinases; MAPKKs; Methods; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Modeling; Molecular; Names; Organism; Osmolar Concentration; Osmolarity; Partner in relationship; Pathway interactions; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Research; Research Ethics Committees; Research Resources; Resources; Role; Scaffolding Protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Transmission; Vertebrate Animals; Vertebrates; Yeasts; abstracting; base; biological signal transduction; cell type; cross-link; crosslink; eukaryotida; expiration; gene product; human subject; living system; mate; pathway; programs; reconstitute; reconstitution; response; scaffold; scaffolding; social role; success; transmission process; vertebrata",Protein Recognition in Signal Transduction,,55040,MSFC,Macromolecular Structure and Function C Study Section,,11,251145,
7751307,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM055560-13,,NIGMS:369995;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"LU, ZHE ;",1869820;,5R01GM055560,05/01/1997,12/31/2010,"1,4-Butanediamine, N,N'-bis(3-aminopropyl)-; Accounting; Back; Binding; Binding (Molecular Function); Blood Glucose; Blood Sugar; Bypass; C-terminal; Cations; Charge; Chronotropism, Cardiac; Chronotropisms, Cardiac; Coupling; Dental Cavity Lining; Dependence; Disease; Disorder; Dorsum; Drops; Electrostatics; Ensure; Equilibrium; Exhibits; Experimental Designs; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Heart Rate; Hydrogen Bonding; Hydrogen Oxide; IRK1 channel; Integral Membrane Protein; Interphase Cell; Intervention; Intervention Strategies; Intrinsic Membrane Protein; Investigators; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; Ions; K+ Channels, Inwardly Rectifying; Kir2.1 channel; Medical; Membrane; Membrane Potentials; Methods and Techniques; Methods, Other; Modeling; Molecular Biology, Mutagenesis; Molecular Interaction; Movement; Mutagenesis; Mutation; Nature; Neural Transmission; Non-dividing Cell; Physiologic; Physiological; Play; Polyamine Compound; Polyamines; Position; Positioning Attribute; Potassium Channels, Inwardly Rectifying; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Research; Research Personnel; Researchers; Resting Cell; Resting Potentials; Role; Side; Sodium Chloride; Sodium chloride (NaCl); Solutions; Spermine; Synaptic Transmission; Techniques; Testing; Transmembrane Potentials; Transmembrane Protein; V (voltage); Water; Xenopus oocyte; balance; balance function; base; body movement; cavity liner; cavity lining; constriction; dental cavity liner; disease/disorder; electric field; experiment; experimental research; experimental study; extracellular; genome mutation; insulin secretion; interventional strategy; inward rectifier potassium channel; kcnj2 channel; membrane structure; particle; prevent; preventing; programs; research study; salt; social role; voltage; voltage gated channel",Mechanisms of permeation in inward rectifier K+ channels,,55560,BSCT,"Biophysics of Synapses, Channels, and Transporters Study Section",,13,369995,
7765587,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM055761-12,,NIGMS:322468;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLOTTESVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"RAVICHANDRAN, KODI S;",1874000;,5R01GM055761,01/01/1998,01/31/2012,"AIDS Virus; AIDS in Pediatric Population; ATGN; Active Follow-up; Address; Affect; Antigens; Antimorphic mutation; Basic Research; Basic Science; Binding; Binding (Molecular Function); Biochemical; Budgets; C-X-C Chemokine Receptor Type 4; CD184 Antigen; CXC-R4; CXCL12; CXCL12 gene; CXCL12 protein; CXCR-4; CXCR4; CXCR4 Receptors; CXCR4 gene; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cellularity; Chemokine (C-X-C Motif) Ligand 12; Chemokine (C-X-C Motif) Receptor 4; Chemokine, CXC Motif, Receptor 4; Cytokine Receptors; Cytokines, Chemotactic; D2S201E; Data; Defect; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Event; Exclusion; FB22; Fusin; Generations; Genetic; Goals; HIV-1; HIV-I; HIV1; HM89; HSY3RR; Health; Homologous Chemotactic Cytokines; Human; Human immunodeficiency virus 1; Human, General; Immigrations; Immune response; Immunodeficiency Virus Type 1, Human; In-Migration; Intercrines; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; L-Tyrosine; LAP3; LCR1; LESTR; LPS-Associated Protein 3; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Link; Lipopolysaccharide-Associated Protein 3; Lymphocyte; Lymphocytic; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mature Thymocyte; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Molecular Interaction; Murine; Mus; NPY3R; NPYR; NPYRL; NPYY3R; Neuropeptide Y Receptor Y3; Null Mouse; Outcome; Outcome Study; PBSF; Pathway interactions; Phenotype; Play; Pre-B Cell Growth Stimulating Factor; Receptor Signaling; Receptor, LESTR; Receptors, Antigen, T-Cell; Receptors, Cytokine; Regulation; Reticuloendothelial System, Thymus; Role; SCYB12; SDF-1; SDF-1 Receptor; SDF-1A; SDF-1B; SDF-1alpha; SDF1; SDF1/PBSF Receptor CXCR4; SDF1A; SDF1B; SH2-containing protein; SHC; SHC1 (Src homology 2 domain-containing) protein; SIS cytokines; Sdf1 protein; Seven-Transmembrane-Segment Receptor, Spleen; Shc protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Src homology 2 domain-containing protein; Src homology 2 domain-containing, transforming protein 1; Staging; Stromal Cell-Derived Factor 1; Stromal Cell-Derived Factor 1 Receptor; Stromal Cells; Study, Outcome; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte Development; TLSF-A; TLSF-B; TPAR1; TYR; Testing; Thymocyte Development; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Transgenic Mice; Tyrosine; Tyrosine Phosphorylation; Tyrosine, L-isomer; Work; abstracting; adapter protein; biological signal transduction; cell growth; chemoattractant cytokine; chemokine; chemokine receptor; follow-up; hIRH; host response; human T cell leukemia virus III; human T lymphotropic virus III; immunogen; immunoresponse; in vivo; insight; lymph cell; migration; mouse model; mutant; notch; notch protein; notch receptors; para-Tyrosine; pathway; pediatric AIDS; protein expression; social role; stromal cell-derived factor-1alpha; thymocyte; thymus derived lymphocyte",Role of Shc in T lymphocyte development and function,,55761,CMIB,Cellular and Molecular Immunology - B Study Section,,12,322468,
7755413,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM056398-11,,NIGMS:320895;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MILWAUKEE,UNITED STATES,ANESTHESIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"HUDETZ, ANTHONY GEORGE;",2089644;,5R01GM056398,08/01/1997,01/31/2012,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2,6-Bis(1-methylethyl)phenol; 2,6-Diisopropylphenol; Anesthesia; Anesthesia procedures; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, General; Anesthetics, Intravenous; Animals; Anterior; Area; Arousal; Behavioral; Brain Stem; Brainstem; Cell Nucleus; Cerebrum; Common Rat Strains; Conscious; Consciousness; Consciousness, Loss of; Depression; Development; Diprivan; Disoprofol; Dorsal; EEG; Electrodes, Miniaturized; Electroencephalography; Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-; Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Evoked Potentials; Feedback; Fore-Brain; Forebrain; Frequencies (time pattern); Frequency; General Anesthesia; General anesthetic drugs; Generations; Glutamates; Goals; Grant; Implant; Intravenous Anesthetics; Isoflurane; L-Glutamate; Levarterenol; Levonorepinephrine; Mammals, Rats; Measurement; Measures; Mental Depression; Methods; Microelectrodes; Microinjections; Monitor; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Neurotensin; Noradrenaline; Norepinephrine; Nucleus; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Play; Propofol; Propofol/Diprivan; Prosencephalon; Rat; Rattus; Reflex; Reflex action; Research; Reticular Formation; Role; Scheme; Science of neurochemistry; Sensory; Structure; Testing; Time; Unconscious; Unconscious State; Unconsciousness; Visual; Visual Cortex; Visual System; Visual system structure; Work; association cortex; basal forebrain; base; cholinergic; density; desflurane; experiment; experimental research; experimental study; frontal cortex; frontal lobe; hypnotic; indexing; instrument; neural; neurobiological; neurobiological mechanism; neurochemistry; neuronal; novel; parietal cortex; public health research; relating to nervous system; research study; response; sensory integration; social role; visual cortical; visual feedback",General anesthetics and cerebral cortical sensory integration,,56398,SAT,"Surgery, Anesthesiology and Trauma Study Section",,11,320895,
7752853,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM056677-14,,NIGMS:266409;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SALT LAKE CITY,UNITED STATES,CHEMISTRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"RAINIER, JON D;",1893373;,5R01GM056677,01/01/1998,12/31/2010,"Acids; Actins; Alkenes; Anhydrides; Antidotes; Antifungal Agents; Antifungal Drug; Antioncogene Protein p53; Area; Binding; Binding (Molecular Function); Binding Sites; Biological; Biological Factors; Biological Function; Biological Process; Biology; Brevenal; C element; C-glycoside; Carbon; Cells; Cellular Tumor Antigen P53; Chemistry; Chemistry, Organic; Ciguatera; Ciguatera Poisoning; Combining Site; Coupling; Cystic Fibrosis; Development; Dinoflagellates; Dinoflagellida; Dinophyceae; Ethers; Factor, Biologic; Family; Family member; Fungicides, Therapeutic; Gambierdiscus toxicus; Generations; Health; Human; Human, General; Industrial fungicide; Ion Channel; Ion Channels, Sodium; Ionic Channels; Lead; Libraries; Lung; Man (Taxonomy); Man, Modern; Marines; Medicine; Membrane Channels; Method LOINC Axis 6; Methodology; Modeling; Molecular; Molecular Interaction; Mucous body substance; Mucoviscidosis; Mucus; Natural Products; Neurotoxins; Olefins; Oncoprotein p53; Organic Chemistry; Organic Synthesis; Organism; Ovis; Pb element; Phosphoprotein P53; Phosphoprotein pp53; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protein TP53; Protein p53; Publications; Pyrrophyta; Reactive Site; Research; Respiratory System, Lung; Science of Chemistry; Science of Medicine; Scientific Publication; Series; Sheep; Site; Skeleton; Sodium Channel; Source; TP53; Theriacs; Toxin; Tumor Protein p53; V (voltage); Work; analog; anti-fungal; antifungals; brevetoxin; brevetoxin PbTx-3; ciguatera fish poisoning; enol; fungicidal; fungicide; gambierol; heavy metal Pb; heavy metal lead; interest; living system; marine natural product; member; mucous; neuron toxicity; neuronal toxicity; neurotoxic; neurotoxicant; neurotoxicity; p53 Antigen; p53 Tumor Suppressor; programs; pulmonary; small molecule; voltage",Fungicidal and Neurotoxic Marine Natural Products,,56677,SBCA,Synthetic and Biological Chemistry A Study Section,,14,266409,
7741734,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM056779-13,,NIGMS:283254;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PITTSBURGH,UNITED STATES,BIOLOGY,14,052184116,US,PA,15213,CARNEGIE-MELLON UNIVERSITY,"LINSTEDT, ADAM D;",1889919;,5R01GM056779,01/01/1998,12/31/2010,"Acute; Assay; Autoantigens; Autoimmune Diseases; Autologous Antigens; Binding; Binding (Molecular Function); Bioassay; Biogenesis; Biologic Assays; Biological Assay; CDC2 Protein Kinase; CDK1; COP-1; COP-I; COPI; COPI Protein; CTBP, transferase-binding; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Controller cdc2; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Control Protein 2 Homolog; Cell Division Cycle; Cell Division Cycle 2; Cell Division Cycle 2 Protein; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Coat Protein Complex I; Coatomer-Coated Vesicles; Complex; Cultured Cells; Cyclin-Dependent Kinase 1; Data; Defect; Disease; Disorder; Docking; Drosophila; Drosophila genus; Enzymes; Family member; Fruit Fly, Drosophila; Glutamic Acid; Goals; Golgi; Golgi Apparatus; Golgi Complex; Golgi transport factor p115; Health; Image; In Vitro; Intracellular Communication and Signaling; Investigators; Kinetic; Kinetics; L-Glutamic Acid; Life; Link; M cell; MAP-ERK Kinase; MAPK ERK Kinases; MEK inhibition; MEKs; Mediating; Membrane; Membrane Fusion; Molecular Interaction; Motility; Motility, Cellular; NSF attachment protein receptor; Origin of Life; Pathway interactions; Phenotype; Phosphorylation; Point Mutation; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Recruitment Activity; Research Personnel; Researchers; Retrieval; Role; SNAP receptor; SNARE; Self-Antigens; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Sorting - Cell Movement; Staging; Structural Protein; Structure; Structure-Activity Relationship; TAP p115; Testing; Tubular; Tubular formation; Unpublished Works (PT); Unpublished Works [Publication Type]; VESCL; Vesicle; Vesicles, COPI-Coated; Work; autoimmune disorder; base; biological signal transduction; cdc2 gene product; cdc2+ Protein; cdk1 Kinase; cell motility; chemical structure function; cytidylyltransferase-binding protein; disease/disorder; experiment; experimental research; experimental study; fruit fly; gene product; gene replacement; genome-wide; imaging; in vivo; insight; membrane structure; novel; p34 (cdc2); p34 Protein Kinase; p34CDC2; pathway; prevent; preventing; programs; recruit; research study; siRNA; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; sorting; structure function relationship; trafficking; transcytosis-associated factor p115; transcytosis-associated protein; unpublished works; vesicle docking protein p115; vesicular transport factor p115",BIOGENESIS OF THE GOLGI APPARATUS,,56779,CSF,Cell Structure and Function Study Section,,13,283254,
7760138,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM056800-15,,NIGMS:274717;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"AMON, ANGELIKA B;",2095469;,5R01GM056800,09/30/1997,01/31/2012,"Address; Affect; Alleles; Allelomorphs; Aneuploid; Aneuploidy; Animal Welfare; Bibliography; Biochemical; Cancers; Cannot achieve a pregnancy; Cell Cycle Progression; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Chromosomes; Country; Difficulty conceiving; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; GTP Phosphohydrolases; GTPases; Genes; Goals; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Human; Human, General; IACUC; IRBs; Impact, Environmental; Infertility; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Light; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Miscarriage; Mitosis; Mitosis Stage; Mitotic; Molecular; Mothers; Names; Pathway interactions; Photoradiation; Plasmids; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Cleavage; Proteolysis; Racial Segregation; Reading; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Spontaneous abortion; Stream; Testing; Vertebrate Animals; Vertebrates; Yeasts; abstracting; expiration; guanosinetriphosphatase; human subject; in vivo; infertile; loss of function; malignancy; neoplasm/cancer; pathway; prevent; preventing; programs; segregation; tumor; unable to bear children; vertebrata",Regulation of Mitosis by Proteolysis in Yeast,,56800,NDT,Nuclear Dynamics and Transport,,15,274717,
7749042,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM056976-13,,NIGMS:298057;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EAST LANSING,UNITED STATES,BIOCHEMISTRY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"ARNOSTI, DAVID N.;",8454144;,5R01GM056976,01/01/1998,12/31/2010,"Animals; Application Context; Assay; Binding; Binding (Molecular Function); Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological; Biological Assay; Biological Models; Blastoderm; Body Pattern Formation; Body Pattern Specification; Body Patterning; C-terminal; C-terminal binding protein; CHIP assay; Cell Communication and Signaling; Cell Signaling; ChIP (chromatin immunoprecipitation); Complex; CtBP protein; DNA; DNA Binding Domain; Deoxyribonucleic Acid; Development; Developmental Gene; Disease; Disorder; Drosophila; Drosophila genus; Effectiveness; Elements; Embryo; Embryonic; Engineered Gene; EngineeredGene; Enhancer Elements; Enhancer Elements (Genetics); Enhancers; Event; Evolution; Flies; Fruit Fly, Drosophila; Gene Action Regulation; Gene Down-Regulation; Gene Expression Process; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene, Developmental; Genes; Genes, Reporter; Genomics; Goals; HDAC; HDAC Proteins; Histone Deacetylase; Intracellular Communication and Signaling; Laboratories; Laboratory Research; Lead; Maps; Math Models; Model System; Modeling; Models, Biologic; Molecular; Molecular Analysis; Molecular Genetic; Molecular Genetics; Molecular Interaction; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nucleic Acid Regulatory Sequences; Orphan; Pathway interactions; Pattern; Pb element; Peptides; Physiologic; Physiological; Play; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein C; Protein Motifs, DNA-Binding; Proteins; RNA Splicing; Regulation; Regulator Regions, Nucleic Acid; Regulatory Element; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; RegulatoryElement; Reporter Genes; Repression; Research; Research, Laboratory; Role; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Surface; Testing; Transcription Activator; Transcription Coactivator; Transcription Corepressor; Transcription Factor Coactivator; Transcription Regulation; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Variant; Variation; Work; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; base; biological signal transduction; chromatin immunoprecipitation; cofactor; contextual factors; design; designing; disease/disorder; fly; fruit fly; gene product; gene repression; genetic enhancer element; genetic regulatory element; heavy metal Pb; heavy metal lead; insight; mathematical model; mathematical modeling; novel; pathway; programs; response; social role; stoichiometry; tool",Molecular Analysis of Transcriptional Repression,,56976,MGB,Molecular Genetics B Study Section,,13,298057,
7754059,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM057014-14,,NIGMS:328802;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ANN ARBOR,UNITED STATES,CHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MONTGOMERY, JOHN ;",1885747;,5R01GM057014,01/01/1998,12/31/2010,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-; 4-Sphingenine; Active Sites; Alcohols; Aldehydes; Alkynes; Anabolism; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Binding; Binding (Molecular Function); Biological; Biological Factors; Cancer Drug; Carbohydrates; Chemical Class, Alcohol; Chemotherapeutic Agents, Neoplastic Disease; Collaborations; Coupling; Cyclization; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; D-Glucose; D-Mannose; Development; Dextrose; Enzymes; Event; Factor, Biologic; Family; Fe element; Glucose; Hydroxyl; Hydroxyl Radical; Investigators; Iron; Laboratories; Lead; Ligands; Macrolides; Mannopyranose; Mannopyranoside; Mannose; Metabolic Glycosylation; Methods; Michigan; Miscellaneous Antibiotic; Molecular Interaction; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Ni element; Nickel; P450; Pb element; Preparation; Procedures; Process; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Reaction; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Series; Si element; Silanes; Silicon; Sites, Active; Solutions; Sphingosine; Staging; Structure; Therapeutic Agents; Tumor-Specific Treatment Agents; United States National Institutes of Health; Universities; Variant; Variation; aigialomycin D; amphidinolide W; anticancer agent; anticancer drug; appendage; base; biosynthesis; desosamine; flexibility; glycosylation; heavy metal Pb; heavy metal lead; improved; member; molecular recognition; novel; oxidation; programs; silane; sugar",New Cyclization Methods and Multicomponent Couplings,,57014,SBCA,Synthetic and Biological Chemistry A Study Section,,14,328802,
7779382,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM057043-11,,NIGMS:322438;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,GENETICS,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"TOMLINSON, ANDREW ;",1863389;,5R01GM057043,01/01/1998,01/31/2013,"Aves; Avian; Axon; Behavior; Binding; Binding (Molecular Function); Biochemical; Biologic Phenomena; Biological Phenomena; Birds; Cell Communication and Signaling; Cell Polarity; Cell Signaling; Cells; Cellular Matrix; Chemotaxis; Complex; Cues; Cytoskeletal System; Cytoskeleton; Distant; Drosophila; Drosophila genus; Ear, Internal; Epithelium; Experimental Organism; Feathers; Fishes; Flies; Fruit Fly, Drosophila; G-Proteins; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GTP GDP exchange factor; GTP-Binding Proteins; GTP-Regulatory Proteins; Genes; Genetic; Genetic Techniques; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Regulatory Proteins; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Hair; Hearing; Immune response; Infection; Intracellular Communication and Signaling; Invaded; Laboratory Organism; Labyrinth; Lesion; Mediating; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Pathway interactions; Phenotype; Play; Process; Proteins; Receptor Protein; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sound; Sound - physical agent; Specificity; Structure; Technics, Genetic; Techniques; Testing; Transducers; Wound Healing; Wound Repair; base; biological signal transduction; cellular polarity; design; designing; exchange factor; fly; fruit fly; gene function; gene product; hearing perception; host response; immunoresponse; inner ear; intracellular skeleton; neuronal; pathogen; pathway; polarized cell; protein complex; public health relevance; receptor; response; social role; sound; sound perception; tissue repair; tool",Signaling Specificity of Drosophila Serpentine Receptors," Project Narrative Polarization of the cytoskeleton within cells is required for many critical bodily processes such as wound healing, formation of nerve connections, and the eradication of infection. A field of cells can coordinately organize their polarizations, as demonstrated by the organization of the cilliary bundles of the inner ear that permit us to hear sound. This application is designed to study planar cell polarity in fruit flies, to understand how cells can polarize and coordinate those polarizations in larger scale structures.",57043,DEV2,Development - 2 Study Section,,11,322438,
7758750,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM058531-12,,NIGMS:280814;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,PHARMACOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"TIRUPPATHI, CHINNASWAMY ;",1917504;,5R01GM058531,02/01/1999,01/31/2011,"APF-1; ATP phosphohydrolase (Ca(2+)-transporting); ATP-Dependent Proteolysis Factor 1; Acute Pulmonary Injury; Address; Adenosine Triphosphatase, Calcium; Agonist; Antigen Receptors; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); Binding Sites; Blast Transformation; Blastogenesis; Blood Vessels; Body Tissues; CAV1; CBL E3 ubiquitin protein ligase; CNOS; Ca(2+)-Transporting ATPase; Ca2+ ATPase; Ca2+ transporting ATPase; Cachectin; Cachectin-Tumor Necrosis Factor; Calcium ATPase; Calcium Adenosinetriphosphatase; Calcium Pump; Cations; Caveolae; Caveolae Protein, 22kD; Caveolas; Caveolin 1, Caveolae Protein, 22kD; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chiro-Inositol; Cloning, Human; Coagulation Factor II Receptor; Combining Site; Complex; Constitutive NOS; Cytosol; Data; Development; Dropsy; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E3 Ligase; E3 Ubiquitin Ligase; ECNOS; ENOS; Edema; Endocytosis; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium, Vascular; Enzymes; Exhibits; F2R; Family; Funding; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gene Deletion; Gene Expression; Gene Family; Genes; HMG-20; High Mobility Protein 20; Human; Human Cloning; Human, General; Hydrops; INFLM; IP3R; IP3R1; ITPR1; ITPR1 gene; Impairment; Inflammation; Inflammation Mediators; Injury; Inositol; Insp3r1; Intracellular Communication and Signaling; Investigation; Investigators; Isoforms; Knock-out; Knockout; Knockout Mice; Laboratories; Lead; Lecithinase C; Leg; Lung; Lung Injury, Acute; Lymphoblast Transformation; Lymphocyte Activation; Lymphocyte Stimulation; Lymphocyte Transformation; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane Protein Traffic; Membrane Traffic; Mesoinositol; Mice; Mice, Knock-out; Mice, Knockout; Microvascular Permeability; Molecular; Molecular Interaction; Murine; Mus; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide Synthase 3; Nuclear; Nucleic Acid Regulatory Sequences; Null Mouse; PAR-1 Receptor; PAR1 Receptor; Pathogenesis; Pb element; Peptide Domain; Peptides; Permeability; Phospholipase C; Play; Production; Programs (PT); Programs [Publication Type]; Protease-Activated Receptor 1; Protein Domains; Protein Family; Protein Isoforms; Proteinase-Activated Receptor 1; Proteins; Pulmonary Edema; Reactive Site; Receptor Activation; Receptor Protein; Receptor Signaling; Receptor, PAR-1; Receptors, Antigen; Recombinants; Recruitment Activity; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Reporting; Research Personnel; Researchers; Respiratory System, Lung; Role; Sepsis; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Protein; Subcellular Process; T-Cells; T-Lymphocyte; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Tertiary Protein Structure; Testing; Thrombase; Thrombin; Thymus-Dependent Lymphocytes; Tissues; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Ubiquitilation; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; VIP21; VIP21 protein; Vascular Endothelial Cell; Vascular Endothelium; Vascular Permeabilities; Work; acute lung injury; base; biological signal transduction; bloodstream infection; c-cbl protein; calcium transporting ATPase; caveolin; caveolin 1; eNOS enzyme; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; fibrinogenase; gene deletion mutation; gene product; genetic regulatory element; heavy metal Pb; heavy metal lead; human NOS3 protein; in vivo; insight; lipophosphodiesterase I; lung edema; lung vascular injury; mouse model; novel; overexpression; phosphatidylcholine cholinephosphohydrolase; prevent; preventing; programs; proto-oncogene protein c-cbl; pulmonary; receptor; recruit; research study; response; scaffold; scaffolding; self recognition (immune); social role; thymus derived lymphocyte; tumor necrosis factor (unspecified); ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase; vascular; vesicular integral membrane protein 21 kDa","Thrombin,Sepsis and Mechanisms of Inflammation",,58531,SAT,"Surgery, Anesthesiology and Trauma Study Section",,12,280814,
7751825,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM058615-09,,NIGMS:389813;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"HSU, VICTOR W;",7346034;,5R01GM058615,02/01/2001,12/31/2010,"4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-; ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; ARF 1 Protein; ARF Protein Cofactor; ARF-GAP1; ARF1 Protein; ARF1p; ARFGAP1; ARFGAP3; Address; Affect; Ascotoxin; Automobile Driving; Biogenesis; Brefeldin A; COP-1; COP-I; COPI; COPI Protein; Capsid Proteins; Clathrin; Coat Protein Complex I; Coat Proteins; Complement; Complement Proteins; Complex; Cyanein; Cytosol; Decumbin; Defect; Disease; Disorder; Drivings, Automobile; GAP Proteins; GTPase-Activating Proteins; Intracellular Transport; Isoforms; Lecithinase D; Membrane; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Origin of Life; Pathway interactions; Phosphatidylcholine Phosphohydrolase; Phospholipase D; Phospholipid Metabolism; Play; Process; Protein Isoforms; Proteins; Role; Small G-Proteins; Small GTPases; Sorting - Cell Movement; Synergisidin; System; System, LOINC Axis 4; Testing; Transport Vesicles; VESCL; Vesicle; Viral Coat Proteins; Viral Outer Coat Protein; disease/disorder; driving; gene product; guanosinetriphosphatase activating protein; human disease; lipophosphodiesterase II; membrane structure; novel; pathway; phosphatidylcholine phosphatidohydrolase; polymerization; protein function; reconstitute; reconstitution; social role; sorting",Biogenesis of Transport Vesicles Coated by COPI,,58615,MBPP,Membrane Biology and Protein Processing Study Section,,9,389813,
7753603,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM058617-12,,NIGMS:362095;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EVANSTON,UNITED STATES,BIOCHEMISTRY,09,160079455,US,IL,602081110,NORTHWESTERN UNIVERSITY,"WIDOM, JONATHAN ;",1897749;,5R01GM058617,01/01/1999,12/31/2010,"Affinity; Architecture; Assay; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Cancer Treatment; Caring; Cell Cycle; Cell Division Cycle; Cells; Chromatin; Chromosomes; Code; Coding System; Color; Combining Site; Communicable Diseases; Coupled; DNA; DNA Replication; DNA Sequence; DNA Synthesis; DNA biosynthesis; DNA-Binding Proteins; DNA-Protein Interaction; Data; Deoxyribonucleic Acid; Development; Diagnosis; Engineering / Architecture; Enzymes; Equilibrium; Eukaryota; Eukaryote; Fungal Genome; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Genome; Genome, Fungal; Genomics; Goals; Grant; Histones; Homologous Recombinational Repair; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Life; Ligand Binding Protein; Location; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Measures; Mechanics; Modeling; Modification; Molecular Interaction; Nature; Nucleosomes; Phase; Position; Positioning Attribute; Procedures; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; Reactive Site; Reading; Recombination Repair; Recruitment Activity; Regulatory Protein; Reporter; Research; Research Personnel; Researchers; Resolution; Role; Series; Site; Structure; Surface; Tail; Testing; Time; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Variant; Variation; Weight; Work; Yeasts; anticancer therapy; balance; balance function; base; cancer therapy; design; designing; eukaryotida; experiment; experimental research; experimental study; gene product; genetic regulatory protein; genome sequencing; genome-wide; improved; in vitro Model; in vivo; in vivo Model; novel; programs; recombinational repair; recruit; regulatory gene product; research study; response; social role; yeast genome",Nucleosome Positioning,,58617,NDT,Nuclear Dynamics and Transport,,12,362095,
7759553,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM059055-10,,NIGMS:295072;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,UNIVERSITY PARK,UNITED STATES,BIOCHEMISTRY,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"PUGH, B FRANKLIN;",1863395;,5R01GM059055,02/01/2000,01/31/2013,"Acetylation; Acetyltransferase; Address; Analysis, Data; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological; Biological Assay; Biological Models; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Bromodomain; CHIP assay; ChIP (chromatin immunoprecipitation); Chromatin; Coagulation Factor I; Coagulation Factor One; Complex; Couples; DNA-Dependent RNA Polymerase II; Data Analyses; Dependency; Dependency (Psychology); Disease; Disorder; Endomycetales; Event; Factor I; Factor One; Fibrinogen; Funding; GTF2D; GTF2D1; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Genetic, Biochemical; Genomics; Health; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Histone Acetylation; Histones; Hogness Box; Holoenzymes; Housekeeping Gene; Human; Human, General; In Vitro; Individual; Instruction; L-Lysine; Lead; Lysine; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Monitor; Motion; Mutate; Nucleosomes; Pathway interactions; Pb element; Phase; Position; Positioning Attribute; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; RNA Expression; RNA Polymerase B; RNA Polymerase II; RNA Polymerase II TATA-Binding Protein; Reading; Recruitment Activity; Regulation; Regulatory Protein; Research; Research Resources; Resources; S cerevisiae; SAGA; SCA17; SPT/ADA/Gcn5 Acetyltransferase; Saccharomyces; Saccharomyces cerevisiae; Saccharomycetales; Sn element; Stannum; Stress; System; System, LOINC Axis 4; TATA Box; TATA Sequence-Binding Protein; TATA-Binding Protein; TATA-Box Binding Protein; TATA-Box Factor; TBP; Tail; Techniques; Testing; Tin; Transcription; Transcription Factor TBP; Transcription, Genetic; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; abstracting; base; chromatin immunoprecipitation; chromatin remodeling; disease/disorder; emotional dependency; experiment; experimental research; experimental study; gene function; genetic regulatory protein; genome-wide; heavy metal Pb; heavy metal lead; in vivo; mutant; pathway; public health relevance; recruit; regulatory gene product; research study; transcription factor",Genome-Wide Regulation of the TATA Binding Protein, Project Narrative Relevance  Human health is highly dependent upon the proper functioning of our genes (biological instructions). This project will contribute to a greater understanding of how genes function by determining how the gene regulatory proteins work together to read the instructions on a global scale.,59055,MGB,Molecular Genetics B Study Section,,10,295072,
7760578,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM059356-10,,NIGMS:367092;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,PEDIATRICS,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"LA SPADA, ALBERT R;",1930750;,5R01GM059356,05/01/1999,01/31/2011,"Abscission; Activator Appliances; Affect; Binding; Binding (Molecular Function); Binding Sites; CAG repeat; CCCTC-binding factor; CCCTC-binding factor, mouse; CHIP assay; CTCF protein; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; ChIP (chromatin immunoprecipitation); Code; Coding System; Combining Site; Complementary DNA; Complex; Ctcf protein, mouse; DNA Structure; DNA, Complementary; DNA-binding protein CTCF; Development; Disease; Disorder; Elements; Employee Strikes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Excision; Exons; Extirpation; Function Activator; Functional RNA; Funding; Gametes; Gene Expression; Gene Products, RNA; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genomics; Germ Cells; Germ Lines; Germ-Line Cells; Human; Human, General; Intracellular Communication and Signaling; Investigators; Mammals, Mice; Man (Taxonomy); Man, Modern; Methylation; Mice; Mice, Transgenic; Modeling; Molecular Interaction; Murine; Mus; Mutate; Mutation; Non-Coding; Non-Coding RNA; Orthodontic Appliances, Activator; Pathway interactions; Pattern; Poly Q; Polyadenylation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Methylation; Proteins; Quelling; RNA; RNA Expression; RNA Interference; RNA Polyadenylation; RNA Silencing; RNA Silencings; RNA methylation; RNA, Non-Polyadenylated; RNAi; Reactive Site; Regulation; Removal; Reproductive Cells; Research Personnel; Researchers; Ribonucleic Acid; Role; SCA7 protein; Sequence-Specific Posttranscriptional Gene Silencing; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Somatic Cell; Spinocerebellar Ataxia-7; Spinocerebellar Ataxias; Spinocerebellar Ataxias, Dominantly-Inherited; Spinocerebellar Atrophies; Strikes; Strikes, Employee; Surgical Removal; Testing; Trans-Acting Factors; Trans-Activators; Transactivators; Transcript; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Trinucleotide Repeats; Triplet Repeats; Type 7 Spinocerebellar Ataxia; ataxin-7; base; biological signal transduction; cDNA; chromatin immunoprecipitation; cis acting element; codon reiteration; disease/disorder; gene product; genome mutation; in vivo; initial cell; mouse CCCTC-binding factor; mutant; neurodegenerative phenotype; novel; pathway; poly(glutamine); polyQ; polyglutamine; premature; programs; recombinase; resection; sexual cell; social role; spinocerebellar ataxia 7 protein; stem; trans acting factor (genetic)",CCCTC-binding factor (CTCF) in trinucleotide repeat instability and disease,,59356,GHD,Genetics of Health and Disease Study Section,,10,367092,
7758198,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM059907-10,,NIGMS:357547;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,CHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"BERTOZZI, CAROLYN R;",1927017;,5R01GM059907,09/30/2004,12/31/2012,"Aldehydes; Anchors, Glycosylphosphatidylinositol; Animal Model; Animal Models and Related Studies; Antigenic Determinants; Architecture; B blood cells; B-Cell Antigen CD22; B-Cells; B-Lymphocyte Cell Adhesion Molecule; B-Lymphocytes; B3 antigen; Bacterial Infections; Behavior; Binding Determinants; Binding Sites; Biological; Biological Function; Biological Process; Blood Group Antigens; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD162 antigen; CD22 antigen; CD22 glycoprotein; CD22 molecule; CD62P Antigens; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell Surface Proteins; Cell membrane; Cell surface; Cell-to-Cell Interaction; Cells; Chemicals; Combining Site; Complex; Consensus Sequence; ConsensusSequence; Cysteine; Cytoplasmic Membrane; Development; Dimerization; Disease; Disorder; EC 2.4; EC 2.8.2; Engineering; Engineering / Architecture; Engineerings; Environment; Enzymes; Epitopes; Eukaryote; Eukaryotic Cell; Event; Figs; Figs - dietary; GMP-140; GPI Membrane Anchors; Generations; Glycans; Glycobiology; Glycoconjugates; Glycoinositol Phospholipid Membrane Anchor; Glycoproteins; Glycoside Transferases; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Goals; Golgi; Golgi Apparatus; Golgi Complex; Grant; Half-Cystine; Hydroxyimino Compounds; INFLM; Immune Cell Activation; Inflammation; Intracellular Communication and Signaling; L-Cysteine; LECAM-3; Leu 14; Life; Ligands; Lyb8; MUC1; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic Glycosylation; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods; Methods and Techniques; Methods, Other; Modification; Molecular; Mucin-1 Staining Method; Mucins; Mucus Glycoprotein; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neoplasm Metastasis; Organ; Oximes; P-Selectin; P-selectin glycoprotein ligand-1; P-selectin ligand protein; PSGL-1; Plasma Membrane; Platelet alpha-Granule Membrane Protein; Play; Polymers; Polysaccharides; Property; Property, LOINC Axis 2; Protein Dimerization; Proteins; Proteins, Cell Surface; Reactive Site; Recombinants; Research; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Selectins; Sialic Acid-Binding Immunoglobulin-Like Lectin 2; Signal Transduction; Signal Transduction Systems; Signaling; Site; Structure; Surface Proteins; Techniques; Technology; Tumor Cell Migration; United States National Institutes of Health; Variant; Variation; Virus; Viruses, General; Work; analog; bacterial disease; biological signal transduction; cancer metastasis; density; design; designing; disease/disorder; enzyme activity; eukaryotida; formylglycine; functional group; gene product; glycosylation; glycosyltransferase; human disease; improved; loss of function; malignancy; membrane model; membrane structure; mimetics; model organism; molecular recognition; neoplasm/cancer; novel; plasmalemma; preference; public health relevance; scaffold; scaffolding; sialic acid binding Ig-like lectin; siglec; siglec-2; small molecule; social role; sugar; sulfotransferase; tool",Chemical Cell Surface Engineering," RELEVANCE / PROJECT NARRATIVE  Complex sugars decorate the surfaces of cells, where they play a role in cell-cell interactions involved in normal biological processes and also in human disease. The goal of this research is to develop chemical tools for studying the functions of complex sugars on the cell surface. These tools will improve our understanding of how sugars contribute to diseases such as cancer and inflammation.",59907,SBCA,Synthetic and Biological Chemistry A Study Section,,10,357547,
7786245,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM060124-11,,NIGMS:334620;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"STELLER, HERMANN ;",2796087;,5R01GM060124,08/01/1999,01/31/2013,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; AIDS; APF-1; API3; ATP-Dependent Proteolysis Factor 1; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Animals; Apopain; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Autoregulation; BIRC4; BIRC4 gene; Basic Research; Basic Science; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Body Tissues; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; CUL-1; CUL3; Cancers; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase Inhibitor; Cell Death; Cell Death, Programmed; Cell Survival; Cell Viability; Cell-Death Protease; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Complex; Cul-1 protein; Cullin 1; Cullin 1 Protein; Cullin Homolog 1; Cullin Homolog 3; Cysteine Endopeptidases; Cysteine Protease; Cysteine Protease CPP32; Cysteine Proteinases; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Disorder of muscle, unspecified; Drosophila; Drosophila genus; E3 Ligase; E3 Ubiquitin Ligase; Enzyme Precursors; Evolution; Family; Fruit Fly, Drosophila; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Goals; Grant; HMG-20; Head; High Mobility Protein 20; Homeostasis; Human; Human, General; IAP Family Protein; IAP protein; IAP protein (apoptosis); IAP1 protein; ICE-like protease; ILP; Immunologic Deficiency Syndrome, Acquired; In Situ; In Vitro; Induction of Apoptosis; Insecta; Insects; Invertebrates, Insects; KIAA0617; Killings; Knockout Mice; Laboratories; Life; Lin-19 protein; Link; MIHA; Macropain; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medicine; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Multicatalytic Proteinase; Murine; Mus; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Mutagenesis, Site-Directed; Mutant Strains Mice; Mutation; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Null Mouse; Oncogenesis; PARP Cleavage Protease; Pathway interactions; Physiological Homeostasis; Play; Predisposition; Process; Proenzymes; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Family; Protein Turnover; Proteins; Proteosome; Regulation; Research; Role; SCA-1; SREBP Cleavage Activity 1; Science of Medicine; Signal Pathway; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sperm; Spermatogenesis; Spermatozoa; Stimulus; Stroke; Susceptibility; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Thiol Protease; Time; Tissues; Tumor Cell; Tumor Suppression; Tumor Suppression, Molecular; Ubiquitilation; Ubiquitin; Ubiquitin family; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Vascular Accident, Brain; Work; XIAP; Yama; Yama protein; Zymogens; base; brain attack; c-IAP1 protein; cIAP1 protein; caspase; caspase-3; cell killing; cell suicide; cellular suicide; cerebral vascular accident; clinical investigation; cullin-3; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; disease/disorder; experiment; experimental research; experimental study; fruit fly; gene product; genome mutation; human disease; in vivo; inhibitor of apoptosis 1 protein; inhibitor-of-apoptosis protein; insight; interdisciplinary approach; malignancy; man; man's; mouse model; mouse mutant; multicatalytic endopeptidase complex; muscular disorder; necrocytosis; neoplasm/cancer; neoplastic cell; neurodegenerative illness; novel; pathway; preclinical study; programs; protein degradation; public health relevance; research study; response; small molecule; social role; sperm cell; stroke; thymocyte; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase; zoosperm",Control of Apoptosis by Drosophila Cell Death Genes," This proposal focuses on negative regulation of caspases, the key executioners of apoptosis (programmed cell death), by a conserved family of ubiquitin pathway proteins. Progress during past grant periods has provided the intellectual basis for developing a novel class of small-molecule cancer therapeutics that are currently being evaluated in human clinical studies, and the results from proposed mouse model studies (aim 2) will have a direct influence on guiding these clinical trials. We will take a multi-disciplinary approach that integrates cellular, molecular genetic and biochemical studies in both Drosophila and the mouse. This is a uniquely powerful approach for taking a project from basic science discoveries to pre-clinical studies. At this time we are the only laboratory in the world that uses both Drosophila and mouse genetics to investigate the regulation of cell death, and to explore how abnormal regulation of this process contributes to human diseases, with a particular focus on cancer. Therefore, this project will have profound implications for both basic science and medicine.",60124,DEV2,Development - 2 Study Section,,11,334620,
7762712,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM060567-11,,NIGMS:326347;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,CHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"CRIMMINS, MICHAEL T.;",1876993;,5R01GM060567,02/01/2000,01/31/2012,"3-hydroxybutanal; 3-hydroxybutyraldehyde; Acetates; Animal Welfare; Bibliography; Biological Factors; Brevenal; Brevetoxin A; Claisen rearrangement; Country; Cyclic Ethers; Ecological impact; Environment; Environmental Impact; Equipment; Ethers; Ethers, Cyclic; Ethics Committees, Research; Factor, Biologic; GB-1 toxin; Glycolates; Grant; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Names; Natural Products; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resources; Technology; Vertebrate Animals; Vertebrates; abstracting; acetaldol; aldol; analog; base; expiration; flexibility; hemibrevetoxin B; human subject; novel; programs; sclerophytin A; sorangicin A; vertebrata",Enantioselective Synthesis of Polyethers,,60567,SBCB,Synthetic and Biological Chemistry B Study Section,,11,326347,
7741661,R01,GM,5,,12/01/2009,11/30/2010,,5R01GM061851-08,,NIGMS:270132;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,PHARMACOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"SZOKA, FRANCIS C;",1886173;,5R01GM061851,07/01/2000,11/30/2010,"(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; (SP-4-2)-Diamminedichloroplatinum; 14-Hydroxydaunomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; 5-Formyl-5,6,7,8-tetrahydrofolic Acid; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid; 7-ethyl-10-hydroxycamptothecin; Acids; Adriamycine; Binding; Binding (Molecular Function); Binding Sites; Brain; Breast; CD44; CD44 gene; CDDP; Cancer cell line; Cancers; Categories; Cell Culture Techniques; Cells; Characteristics; Chemical Structure; Chemicals; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Colon; Combination Chemotherapy Regimen; Combining Site; Computer Assisted; Cysplatyna; DDP; DOX; Data; Dichlorodiammineplatinum; Docking; Doxorubicin; Doxorubicina; Drug Combinations; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; Encapsulated; Encephalon; Encephalons; Epithelial; Esters; Exhibits; Folinic Acid; Folinic Acid-SF; Formulation; Formulations, Drug; Funding; Genital System, Male, Prostate; Goals; Heart; Human; Human Prostate; Human Prostate Gland; Human, General; Hyaluronan; Hydrolysis; Hydroxyl Daunorubicin; Hydroxyldaunorubicin; Immune system; Individual; Kidney; Kinetic; Kinetics; L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; L-Leucovorin; Length; Leucovorin; Leukovorum; Levofolinic acid; Levoleucovorin; Ligand Binding; Ligands; Link; Lipids; Liposomal; Liposomes; Liver; Lung; Lytotoxicity; MDU3; Malignant Cell; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Medication; Mice; Modeling; Molecular Interaction; Murine; Mus; N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid; N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid; Nervous System, Brain; Normal Tissue; Normal tissue morphology; Oligosaccharides; Oncologist; Ovarian; Peyrone's Chloride; Peyrone's Salt; Pgp1; Pharmaceutic Preparations; Pharmaceutical Preparations; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Property; Property, LOINC Axis 2; Prostate; Prostate Gland; Prostatic Gland; Quimioterapia; Reactive Site; Receptor Protein; Research; Respiratory System, Lung; Safety; Structure; Surface; Testing; Therapeutic; Toxic effect; Toxicities; Tumor Cell; Urinary System, Kidney; body system, allergic/immunologic; body system, hepatic; cancer cell; cancer chemotherapy; chemotherapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; citrovorum; computer aided; cytotoxicity; density; design; designing; drug/agent; improved; late endosome; malignancy; melanoma; neoplasm/cancer; neoplastic cell; novel; organ system, allergic/immunologic; organ system, hepatic; pulmonary; receptor; renal; success; tumor",Targeted Drug Delivery to Surface Receptors,,61851,DMP,Drug Discovery and Molecular Pharmacology Study Section,,8,270132,
7748970,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM062136-08,,NIGMS:267978;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"GRANDO, SERGEI A;",1898258;,5R01GM062136,12/01/2000,12/31/2010,"1-Phosphatidylinositol 3-Kinase; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-Hydroxy-N,N,N-trimethylethanaminium; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Acetylcholine; Acetylcholine Agents; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adhesions; Agents, Muscarinic; Agonist; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Assay; Autocrine Systems; Beds; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Metamorphosis; Blotting, Western; CaM KII; CaM PK II; CaM kinase II; CaMKII; Cadherins; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Communication and Signaling; Cell Locomotion; Cell Maturation; Cell Migration; Cell Movement; Cell Signaling; Cell-Cell Adhesion; Cell/Tissue, Immunohistochemistry; Cells; Cellular Migration; Cellular Regulation; Chemotaxis; Chemotherapy-Hormones/Steroids; Choline; Cholinergic Agents; Cholinergic Agonists, Nicotinic; Cholinergic Drugs; Cholinergic Receptors; Cholinergics; Cholinoceptive Sites; Cholinoceptors; Cutaneous Disorder; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytofluorometry, Flow; Cytokines, Chemotactic; Data; Deoxyguanylate Cyclase; Dermatoses; Development; Drugs; ELISA; Endocrine Gland Secretion; Enzyme-Linked Immunosorbent Assay; Enzymes; Epidermis; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Event; Exhibits; Extracellular Matrix, Integrins; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Funding; G-Proteins; GTP pyrophosphate-lyase (cyclizing); GTP-Binding Proteins; GTP-Regulatory Proteins; Gated Ion Channel; Gene Expression Inhibitor; Glycoproteins; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanyl Cyclase; Guanylate Cyclase; Homologous Chemotactic Cytokines; Hormones; Human; Human, General; IHC; Immigrations; Immunohistochemistry; Immunohistochemistry Staining Method; In-Migration; Individual; Inosinate Cyclase; Integrins; Intercrines; Intracellular Communication and Signaling; Investigators; Knockout Mice; Knowledge; Lateral; Liver Cell Adhesion Molecules; Locomotion; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medical; Medication; Metabolic; Metamorphosis, Biological; Method LOINC Axis 6; Methodology; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Molecular; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinics; Nicotinic Agonists; Null Mouse; Oligonucleotides, Antisense; PI-3 Kinase; PI-3K; PI3-Kinase; PKA; PKC; PKG; Paracrine Communication; Paracrine Signaling; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Process; Protein Kinase; Protein Kinase A; Protein Kinase C; Protein Kinase G; Protein Phosphorylation; PtdIns 3-Kinase; RNA, Small Interfering; Ras/Raf; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Receptors, Muscarinic; Regimen; Regulation; Research; Research Personnel; Researchers; SIS cytokines; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Skin; Skin Diseases; Skin Diseases and Manifestations; Small Interfering RNA; Staging; System; System, LOINC Axis 4; Therapeutic; Therapeutic Agents; Therapeutic Hormone; Time; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Western Blotting; Western Blottings; Western Immunoblotting; Work; Wound Healing; Wound Repair; adenosine 3'5' monophosphate; adenylcyclase; autocrine; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cell growth regulation; cell motility; chemoattractant cytokine; chemokine; cholinergic; design; designing; drug/agent; flow cytophotometry; glycogen synthase a kinase; guanosine 3'5' monophosphate; guanylyl cyclase; hydroxyalkyl protein kinase; keratinocyte; liver cell adhesion molecule; metamorphosis; migration; paracrine; pathway; phosphorylase b kinase kinase; protein blotting; receptor; receptor coupling; rho; sedentary; siRNA; skin disorder; tissue repair; tool; wound",Regulation of Keratinocyte Migration by Acetylcholine,,62136,SAT,"Surgery, Anesthesiology and Trauma Study Section",,8,267978,
7743095,R01,GM,5,,12/01/2009,11/30/2010,,5R01GM062188-09,,NIGMS:345329;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"PITTET, JEAN-FRANCOIS ;",6479141;,5R01GM062188,01/11/2001,11/30/2010,"3'5'-cyclic ester of AMP; 7B4 Antigen; 7B4 protein; ARDS; ARDS, Human; ARDSs, Human; Abscission; Actins; Acute Pulmonary Injury; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adult RDS; Adult Respiratory Distress Syndrome; Alveolar; Alveolar Macrophages; Attenuated; Balance, Fluid; Binding; Binding (Molecular Function); Blood Vessels; Blood capillaries; Blood flow; CD144 Antigen; CDH5; Capillaries; Capillary; Capillary, Unspecified; Carrier Proteins; Cell Communication and Signaling; Cell Signaling; Circulatory Collapse; Client; Common Rat Strains; Complex; Cyclic AMP; Development; Dissociation; Distal; Dropsy; Eating; Edema; Endothelial Cells; Epithelial; Epithelial Cells; Epithelium; Excision; Extirpation; Extravasation; Fluid Balance; Food Intake; Gene Expression; Gene Proteins; Gene Transcription; Genetic; Genetic Transcription; Goals; Grant; HSP; Heat Shock; Heat shock proteins; Heat-Shock Reaction; Heat-Shock Response; Hepatocyte Nitric Oxide Synthase; Human; Human, General; Hydrops; INOS; ISGF-3; Impairment; Inducible Nitric Oxide Synthase; Injury; Intracellular Communication and Signaling; Investigators; Ions; Ischemia; Knockout Mice; Laboratories; Leakage; Liquid substance; Lung; Lung Injury, Acute; Macrophage Nitric Oxide Synthase; Macrophages, Alveolar; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Murine; Mus; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide Synthase 2A; Null Mouse; Pathway interactions; Patients; Permeability; Phase; Phosphorylation; Physiologic; Physiological; Programs (PT); Programs [Publication Type]; Protein Gene Products; Protein Phosphorylation; Proteins; Pulmonary Edema; Pulmonary Macrophages; RNA Expression; Rat; Rattus; Reagent; Removal; Reperfusion Therapy; Research Personnel; Researchers; Resolution; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Rodent Model; Role; STAT1; STAT1 gene; STAT91; Shock; Shock Lung; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spillage; Stress; Stress Fibers; Stress Proteins; Surgical Removal; Techniques; Testing; Therapeutic; Transcription; Transcription, Genetic; Transplant Recipients; Transplantation; Transport Proteins; Transporter Protein; Trauma; Up-Regulation; Up-Regulation (Physiology); Upregulation; VE-Cadherin; VEGFs; Vascular Endothelial Cadherin; Vascular Endothelial Cadherin 1; Vascular Endothelial Growth Factors; Vascular Permeabilities; Vegf; acute lung injury; adenosine 3'5' monophosphate; biological adaptation to stress; biological signal transduction; cAMP; cadherin 5; capillary; cellular targeting; circulatory shock; clinical relevance; clinically relevant; experiment; experimental research; experimental study; fluid; gene product; human NOS2A protein; iNOS enzyme; in vivo; insight; intervention development; liquid; loss of function; lung development; lung edema; lung injury; mouse model; nitric oxide synthase, Type II; pathway; prevent; preventing; programs; prophylactic; protective effect; protein expression; pulmonary; reaction; crisis; reperfusion; research study; resection; response; social role; stress protein; stress response; stress; reaction; therapy development; transplant; transplant patient; treatment development; vascular",Heat shock and lung fluid balance,,62188,SAT,"Surgery, Anesthesiology and Trauma Study Section",,9,345329,
7752845,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM062502-07,,NIGMS:395753;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,,08,120989983,US,MA,021421479,WHITEHEAD INSTITUTE FOR BIOMEDICAL RES,"PLOEGH, HIDDE L;",1888151;,5R01GM062502,07/01/2001,12/31/2011,"APF-1; ATP-Dependent Proteolysis Factor 1; B-Cell Activation; Binding Proteins; Biochemical; Blast Transformation; Blastogenesis; Cells; Chemicals; Complex; Defect; Deubiquitinating Enzyme; Development; Disease; Disorder; Engineering; Engineerings; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Esteroproteases; Expression Profiling; Expression Signature; Family; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; HMG-20; Hand; High Mobility Protein 20; High Throughput Assay; In Vitro; Infection; Intervening Protein Sequence; Intervention; Intervention Strategies; Investigators; Ligand Binding Protein; Lymphoblast Transformation; Lymphocyte Activation; Lymphocyte Stimulation; Lymphocyte Transformation; Membrane Protein Traffic; Membrane Traffic; Molecular Fingerprinting; Molecular Profiling; Outcome; Pathway interactions; Peptidases; Peptide Hydrolases; Peptide Library; Peptides; Position; Positioning Attribute; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteases; Protein Cleavage; Protein Introns; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Proteomics; Reaction; Receptor Protein; Research Personnel; Researchers; Role; Specificity; Ubiquitin; base; design; designing; disease/disorder; enzyme activity; gene product; high throughput screening; in vivo; inhibitor; inhibitor/antagonist; intein; interventional strategy; microbial; molecuar profile; molecular signature; pathway; programs; receptor; small molecule; social role; ubiquitin ligase",Chemical approaches towards the study deubiquitinating enzymes,,62502,MBPP,Membrane Biology and Protein Processing Study Section,,7,395753,
7758707,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM063716-08,,NIGMS:428859;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"XU, RUI-MING ;",1884289;,5R01GM063716,08/01/2001,12/31/2010,"Address; Age; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Biology; Cancer Drug; Cancers; Cells; Chemotherapeutic Agents, Neoplastic Disease; Chromatin; Core Particle; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Development; Dosage Compensation; Dosage Compensation (Genetics); EC 2.1.1; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Funding; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genomics; Goals; HDAC; HDAC Proteins; Heterochromatin; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Histone Code; Histone Deacetylase; Histone H4; Histones; Human; Human, General; Knowledge; L-Lysine; Lyonization; Lysine; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mating Types; Mating-Type Genes; Methyltransferase; Molecular; Mutation; Nucleosome Core; Nucleosome Core Particle; Play; Polycomb; Proteins; Reagent; Recruitment Activity; Regulation; Research; Resolution; Role; S cerevisiae; Saccharomyces cerevisiae; Single Crystal Diffraction; Structure; Substrate Specificity; Therapeutic Agents; Tumor-Specific Treatment Agents; X Inactivation; X Ray Crystallographies; X-Chromosome Inactivation; X-Ray Crystallography; Yeast, Baker's; Yeast, Brewer's; Yeasts; anticancer agent; anticancer drug; base; gene product; genome mutation; histone H3 methyltransferase; histone methylase; histone methyltransferase; histone modification; insight; malignancy; methylase; neoplasm/cancer; protein structure; recruit; small molecule; social role; tool; transmethylase",Structural Studies of Transcriptional Silencing,,63716,MSFC,Macromolecular Structure and Function C Study Section,,8,428859,
7760054,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM063798-07,,NIGMS:303089;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SYRACUSE,UNITED STATES,BIOCHEMISTRY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"SCHMITT, MARK E;",1968447;,5R01GM063798,02/01/2003,01/31/2012,"Anemia; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Appearance; Biochemical; Biological; Biological Models; Cancer Control; Cancer Control Science; Cancer Drug; Cancers; Cartilage; Cartilagenous Tissue; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Function; Cell Process; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chemotherapeutic Agents, Neoplastic Disease; Collaborations; Complex; Data; Degradation, mRNA; Development; Disease; Disorder; Endoribonucleases; Enzymes; Eukaryota; Eukaryote; FLR; Failure (biologic function); Gene Products, RNA; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic Diseases, Inborn; Genetic Models; Genetic defect; Germinoblastoma; Growth; Hair; History; Human; Human, General; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; Inborn Genetic Diseases; Inherited disorder; Intermediary Metabolism; Lead; Learning; Location; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; METBL; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Messenger RNA; Metabolic Processes; Metabolism; Micro RNA; MicroRNAs; Model System; Models, Biologic; Models, Genetic; Molecular; Molecular Analysis; Multienzyme Complexes; Mutation; Nucleases, RNA; Organelles; Pathogenesis; Pb element; Phenotype; Play; Predisposition; Process; Proteins; RNA; RNA endonuclease; RNA, Messenger; RNA, Non-Polyadenylated; RNP; RNase; Recording of previous events; Regulation; Reticulolymphosarcoma; Ribonuclease Family Protein; Ribonucleases; Ribonucleic Acid; Ribonucleoproteins; Risk; Role; S cerevisiae; Saccharomyces cerevisiae; Sarcoma, Germinoblastic; Staging; Structure; Subcellular Process; Susceptibility; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Tumor-Specific Treatment Agents; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; anticancer agent; anticancer drug; base; cell biology; design; designing; disease phenotype; disease/disorder; endoribonuclease; enzyme complex; eukaryotida; experiment; experimental research; experimental study; failure; gene product; genome mutation; heavy metal Pb; heavy metal lead; human disease; hypoimmunity; immune deficiency disorder; immunodeficiency; inborn error; insight; mRNA; mRNA Transcript Degradation; malignancy; miRNA; mutant; neoplasm/cancer; ontogeny; public health relevance; research study; social role",Control of the cell cycle by mRNA degradation,,63798,NDT,Nuclear Dynamics and Transport,,7,303089,
7738936,R01,GM,5,,12/01/2009,11/30/2010,,5R01GM065227-08,,NIGMS:279180;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBUS,UNITED STATES,GENETICS,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"HERMAN, PAUL K;",3146220;,5R01GM065227,04/01/2002,11/30/2010,"ATP-protein phosphotransferase; Address; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Aging; Apoptosis; Apoptosis Pathway; Autophagocytosis; Autophagosome; Biology; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Complex; Cues; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Protein; Data; Degradation Pathway; Degradative Pathway; Development; Disease; Disorder; Ensure; Eukaryota; Eukaryote; Eukaryotic Cell; Event; Future; G0 Phase; G0 state; GFAC; Gene Products, ras; Generalized Growth; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Interphase Cell; Intracellular Communication and Signaling; Investigators; Knowledge; Link; Lysosomes; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Membrane; Molecular; Non-dividing Cell; Nutrient; Organelles; Organism; Output; PKA; Pathway interactions; Phase; Phosphorylation; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Protein Kinase; Protein Kinase A; Protein Phosphorylation; Regulation; Research Personnel; Researchers; Resistance; Rest; Resting Cell; Role; S cerevisiae; Saccharomyces cerevisiae; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Structure; Tissue Growth; Translating; Translatings; VESCL; Vacuole; Vesicle; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; autophagy; biological signal transduction; cAMP-Dependent Protein Kinases; cell growth; disease/disorder; eukaryotida; experiment; experimental research; experimental study; glycogen synthase a kinase; hydroxyalkyl protein kinase; insight; interest; language translation; living system; malignancy; membrane structure; neoplasm/cancer; ontogeny; pathogen; pathway; phosphorylase b kinase kinase; ras Proteins; research study; resistant; response; senescent; social role",Ras protein signaling and the control of cell growth,,65227,CSD,Cellular Signaling and Dynamics Study Section,,8,279180,
7751928,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM065989-06,,NIGMS:338994;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"JONES, ALAN M.;",6140649;,5R01GM065989,09/01/2002,12/31/2012,"Abate; Adaptor Protein; Adaptor Signaling Protein; Affect; Animal Model; Animal Models and Related Studies; Apical; Arabidopsis; Assay; Autoregulation; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Boxing; C elegans; C.elegans; Caenorhabditis elegans; Cancer Genes; Cancer-Promoting Gene; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Surface Receptors; Cell surface; Cells; Cellular Expansion; Cellular Growth; Cellular Proliferation; Chemotherapy-Hormones/Steroids; Chronic; Collaborations; Collection; Complex; Coupled; Coupling; D-Glucose; D-gluconate; D-gluconic acid; Data; Developmental Process, Multicellular; Dextrose; Disease; Disorder; Dissociation; Drosophila melanogaster; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Therapy; Elements; Endocrine Gland Secretion; Engineering; Engineerings; Equilibrium; Eukaryota; Eukaryote; Figs; Figs - dietary; G Protein-Coupled Receptor Genes; G-Protein Regulating Factors; G-Proteins; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GPCR; GPR; GTP; GTP Binding; GTP GDP exchange factor; GTP Phosphohydrolases; GTP-Binding Protein Regulators; GTP-Binding Proteins; GTP-Regulatory Proteins; GTPases; Generalized Growth; Genes; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Germination; Glucose; Goals; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Regulatory Proteins; Guanine Nucleotide Releasing Factors; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Homeostasis; Hormones; Human; Human Engineering; Human, General; Hydrolysis; Immunologic, Luciferase; In Vitro; In element; Indium; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Kinetic; Kinetics; Length; Ligand Binding; Ligands; Luciferases; Man (Taxonomy); Man, Modern; Measures; Mediating; Meristem; Methods; Mitogenesis; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mother Cells; Mutation; Nerve Transmitter Substances; Neurotransmitters; Nucleotides; Oncogenes; Organism; Organism-Level Process; Organismal Process; Ortholog; Orthologous Gene; Pathway interactions; Pharmacology; Pharmacotherapy; Photoaffinity Labels; Physiologic; Physiologic Processes; Physiological; Physiological Homeostasis; Physiological Processes; Plant Embryos; Plant Roots; Plants; Plants, General; Positive Control of Cell Proliferation; Progenitor Cells; Property; Property, LOINC Axis 2; Proteins; Publishing; Receptor Protein; Receptors, Cell Surface; Recombinants; Regulating Factors, GTP-Binding Protein; Regulation; Regulators, G-Protein Signaling; Regulatory Element; Regulatory Protein; RegulatoryElement; Reporter Genes; Research; Role; Saccharomyces; Seeds; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Stem cells; Stimulation of Cell Proliferation; Structure; TM Domain; Testing; Therapeutic Hormone; Tissue Development Process; Tissue Growth; Transforming Genes; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Uncertainty; Work; Yeasts; Zygotes, Plant; balance; balance function; base; biological signal transduction; blood glucose regulation; cell growth; comparative; dimer; disease/disorder; doubt; driving force; drug discovery; eukaryotida; exchange factor; experiment; experimental research; experimental study; gene discovery; gene product; genetic regulatory protein; genome mutation; gluconate; gluconic acid; glucoreceptors; glucose control; glucose homeostasis; glucose receptor; glucose regulation; guanosinetriphosphatase; histogenesis; human disease; in vivo; innovate; innovation; innovative; insight; interest; living system; meetings; model organism; mutant; novel; nucleotide receptor; ontogeny; pathway; physical property; protein complex; protein structure; prototype; public health relevance; receptor; regulatory gene product; research study; root; seed; small molecule; social role; sugar; tool",Novel Mechanisms Regulating the Heterotrimeric G Protein Complex,"  The rationale for the proposed work is that an understanding of molecular mechanisms used in divergent signaling pathways will yield new drug targets, new ideas for manipulating human signaling pathways, and new tools to engineer human pathways.",65989,ZRG1,Special Emphasis Panel,,6,338994,
7763262,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM066569-08,,NIGMS:274442;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MINNEAPOLIS,UNITED STATES,BIOCHEMISTRY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"WILMOT, CAROLINE MARY;",7021064;,5R01GM066569,07/01/2002,01/31/2012,"2,4,5-trihydroxyphenylalanine; 2,5-dihydroxytyrosine; 3,4,6-TOPA; 3,4,6-trihydroxyphenylalanine; 6-OHDOPA; 6-hydroxydopa; Aerobic; Aldehydes; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amine Oxidase (Copper-Containing); Amine[{..}]oxygen oxidoreductase (deaminating)(copper-containing); Amines; Amino Acid Biosynthesis; Amino Acids; Anabolism; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Bacteria; Behavior; Biogenesis; Biology; Cancer Causing Agents; Carcinogens; Cardiac Diseases; Cardiac Disorders; Catalysis; Chemicals; Chemistry; Complex; Complications of Diabetes Mellitus; Congestive; Copper; Copper Amine Oxidase; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cu element; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Cytochrome c Peroxidase; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diabetes Complications; Diabetes-Related Complications; Diabetic Complications; Diamine Oxidase; Drugs; Enzymes; Evolution; Family; Fat-Soluble Vitamin; Fatty Acids; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferrocytochrome c[{..}]hydrogen-peroxide oxidoreductase; Ferroprotoporphyrin; Freezing; Genes; Grant; H2O2; Hansenula; Heart Diseases; Heme; Heme b; Herbicides; Histaminase; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypoxia; Hypoxic; Inflammatory Response; Insecticides; Ions; L-Tryptophan; Levotryptophan; Life; Link; Man (Taxonomy); Man, Modern; Medication; Metabolic; Metals; Micrococcus denitrificans; Microspectrophotometry; Molecular; O element; O2 element; Oncogens; Origin of Life; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen Deficiency; P450; Paracoccus denitrificans; Peroxidases; Pharmaceutic Preparations; Pharmaceutical Preparations; Pichia; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Protoheme; Protoheme IX; Quinone Compound; Quinones; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Redox; Roentgen Rays; Role; Science of Chemistry; Semicarbazide-Sensitive Amine Oxidase; Single Crystal Diffraction; SoxA enzyme; Steroid Compound; Steroids; Structure; Trimethylamine-N-oxide reductase; Tryptophan; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; Yeasts; aminoacid; aminoacid biosynthesis; base; biosynthesis; cofactor; dementia of the Alzheimer type; diamino oxhydrase; diheme cytochrome c; drug metabolism; drug/agent; fatty acid biosynthesis; ferroheme; gene product; heart disorder; man; man's; metal complex; methylamine dehydrogenase; methylamine oxidase; mutant; novel; oxidation reduction reaction; polypeptide; primary degenerative dementia; primary-amine dehydrogenase; senile dementia of the Alzheimer type; social role; therapeutic target",Biosynthesis of Amino Acid Derived Quinone Cofactors,,66569,MSFA,Macromolecular Structure and Function A Study Section,,8,274442,
7774379,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM066972-07,,NIGMS:315184;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,ENGINEERING (ALL TYPES),07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"OSTERMEIER, MARC A;",1977662;,5R01GM066972,07/01/2003,12/31/2012,"ANK Domain; ANK Repeat; ATP-protein phosphotransferase; Address; Affinity; Algorithms; Ankyrin Repeat; Ankyrin Repeat Domain; Arts; Assay; Basic Research; Basic Science; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biosensor; Bypass; Cancer Treatment; Cancer cell line; Cancer of Prostate; Cancers; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Colon; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Complex; Coupling; Cultured Cells; DNA Recombination; DNA recombination (naturally occurring); Detection; Development; Diagnostic; Drug Precursors; EC 2.7; EC 2.7.2-; Engineering; Engineerings; Enzymes; Extracellular Signal-Regulated Kinases; Funding; GDEPT; Gene Fusion; Gene-Directed Enzyme Prodrug Therapy; Genes; Genes, Switch; Genetic Alteration; Genetic Change; Genetic Engineering of Proteins; Genetic Recombination; Genetic defect; Immunoassay; In Vitro; Intracellular Communication and Signaling; JNK; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2Alpha; JNK2B; JNK2Beta; Kinases; Lactamase; Libraries; Life; Ligands; MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK8; MAPK8 gene; MAPK9; MAPK9 gene; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammalian Cell; Methods; Mitogen-Activated Protein Kinases; Modality; Molecular; Molecular Interaction; Mutation; Normal Cell; One Step; One-Step dentin bonding system; Output; PC3 cell line; PRKM8; PRKM9; Peptides; Phosphotransferases; Pro-Drugs; Prodrugs; Prostate CA; Prostate Cancer; Prostatic Cancer; Protein Engineering; Protein Kinase; Proteins; Reagent; Recombination; Recombination, Genetic; Reporter; Research Proposals; SAPK1; Screening procedure; Selection (Genetics); Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Subcellular Process; Surface; Switch Genes; Testing; Therapeutic; Toxic effect; Toxicities; Transphosphorylases; Transplantation; anticancer therapy; biological signal transduction; cancer cell; cancer therapy; combinatorial; cultured cell line; design; designing; enzyme activity; experiment; experimental research; experimental study; expression vector; gene product; genome mutation; glycogen synthase a kinase; homologous recombination; hydroxyalkyl protein kinase; in vivo; intervention design; malignancy; maltose-binding protein; meetings; member; neoplasm/cancer; novel; p54aSAPK; phosphorylase b kinase kinase; prostate cancer cell line; protein function; public health relevance; research study; screening; screenings; sensor; sensor (biological); theories; therapeutic protein; therapeutic target; therapy design; transplant; treatment design",The Combinatorial Design of Protein Molecular Switches, Project Narrative Engineered protein switches hold great promise as selective protein therapeutics and as biosensors for diagnostic and basic science applications. We will develop switches designed for the treatment of cancer and switches designed to be used as sensors for the detection and quantification of important protein kinases in vitro and in live cells.,66972,MSFB,Macromolecular Structure and Function B Study Section,,7,315184,
7751203,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM067100-08,,NIGMS:304989;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,DERMATOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"LI, WEI ;",1898112;,5R01GM067100,01/01/2003,12/31/2010,"Acute; Antimorphic mutation; Back; Beds; Binding; Binding (Molecular Function); Blood Plasma; Blood Serum; Bypass; CD140B; CD140b Antigens; CSF-1; CSF1; Cell Communication and Signaling; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell membrane; Cells; Cellular Migration; Cellular Proliferation; Chimera; Chimera organism; Colony-Stimulating Factor 1; Complex; Credentialing; Cytoplasmic Membrane; Dermal; Dimerization; Docking; Doctor of Philosophy; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; EGFR; ERBB Protein; ERBB1; Environment; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Event; Extracellular Signal-Regulated Kinase Gene; FADK; FAK; FAK1; FGF-R; FGFR; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Fibroblasts; GFAC; Gene Expression; Genes; Genetic Alteration; Genetic Change; Genetic defect; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HER1; Healed; Human; Human Migration / Distribution; Human, General; Intracellular Communication and Signaling; Investigators; JNK; JNK1; JNK1A2; JNK21B1/2; JTK12; Knowledge; L-Tyrosine; L-tyrosine, dihydrogen phosphate (ester); Lentiviral Vector; Lentivirus Vector; Link; M-CSF; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK11; MAPK11 gene; MAPK8; MAPK8 gene; MCSF; Macrophage Colony-Stimulating Factor; Man (Taxonomy); Man, Modern; Mediating; Medication; Mitogen-Activated Protein Kinase Gene; Molecular Interaction; Motility; Motility, Cellular; Mutation; P38B; P38BETA2; PDGF; PDGF-BB; PDGF-R-Beta; PDGFR; PDGFR beta; PDGFR1; PDGFRB; PDGFRB gene; PRKM11; PRKM8; PTK Receptors; PTK2; PTK2 gene; Pathway interactions; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotyrosine; Physiologic; Physiological; Plasma; Plasma Membrane; Platelet-Derived Growth Factor; Platelet-Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor Beta Polypeptide; Platelet-Derived Growth Factor beta Receptor; Process; Programs (PT); Programs [Publication Type]; Protein Dimerization; Publications; RNA, Small Interfering; RTK; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, EGF; Receptor, PDGF beta; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, FGF; Receptors, PDGF; Recruitment Activity; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; SAPK1; SAPK2; SAPK2B; Scientific Publication; Serum; Serum, Plasma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin; Small Interfering RNA; Specificity; System; System, LOINC Axis 4; TYR; Transforming Growth Factor alpha Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine; Tyrosine Kinase Domain; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine, L-isomer; Tyrosine-O-phosphate; Up-Regulation; Up-Regulation (Physiology); Upregulation; Wound Healing; Wound Repair; angiogenesis; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cell motility; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experience; experiment; experimental research; experimental study; genome mutation; healing; human migration; insight; keratinocyte; macrophage; migration; mutant; overexpression; p38-2; p38Beta; para-Tyrosine; pathway; plasmalemma; platelet-derived growth factor BB; pp125FAK; prevent; preventing; programs; proto-oncogene protein c-erbB-1; receptor; reconstitute; reconstitution; recruit; research study; siRNA; skills; stable cell line; tissue repair; transduction efficiency; wound",Mechanism of Human Dermal Fibroblast Migration,,67100,SAT,"Surgery, Anesthesiology and Trauma Study Section",,8,304989,
7760620,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM067113-08,,NIGMS:322788;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,BIOCHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"XIONG, YUE ;",1898071;,5R01GM067113,02/01/2003,01/31/2011,"BA554C12.1; Back; Binding; Binding (Molecular Function); Biochemical; CDT1; CDT1 Gene; CUL3; CUL3 gene; CUL4A; CUL4A gene; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Computer Simulation; Computerized Models; DNA Damage; DNA Injury; Dorsum; E3 Ligase; E3 Ubiquitin Ligase; Family; Gene Transcription; Genetic; Genetic Transcription; Goals; HCDT1; Investigation; Investigators; KIAA0617; Knockout Mice; Licensing Factor; Ligase; M Phase; M phase (cell cycle); MGC13357; MGC1481; Mathematical Model Simulation; Mathematical Models and Simulations; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mitosis; Mitosis Stage; Mitotic; Models, Computer; Molecular Interaction; Mutant Strains Mice; Null Mouse; Play; Protein Binding; Proteins; Proteomics; RBX1; RBX1 gene; RNA Expression; ROC1; Recruitment Activity; Regulation; Replication Licensing; Research; Research Personnel; Researchers; Role; Series; Simulation, Computer based; Subcellular Process; Synthetases; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Ubiquitin-Protein Ligase E3; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; base; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; d-Numb; gene product; in silico; in vivo; mouse mutant; numb protein; recruit; response; social role; ubiquitin ligase; ubiquitin-protein ligase; virtual simulation",The Cullin-ROC Family of E3 Ubiquitin Ligases,,67113,CSD,Cellular Signaling and Dynamics Study Section,,8,322788,
7760094,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM067132-08,,NIGMS:369171;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,PATHOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"DYNLACHT, BRIAN D;",1872944;,5R01GM067132,02/01/2003,01/31/2011,"Area; Binding; Binding (Molecular Function); Biochemistry; Body Tissues; Bone; Bone and Bones; Bones and Bone Tissue; Cancers; Cell Cycle; Cell Cycle Progression; Cell Division Cycle; Cells; Chemistry, Biological; Chromatin; Complex; Computational Biology; Cues; Cultured Cells; Family; Funding; GWAS; Gene Action Regulation; Gene Cluster; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Targeting; Generalized Growth; Genes; Genome; Grant; Growth; HDAC; HDAC Proteins; Histone Deacetylase; Human; Human, General; Learning; Location; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methylation; Mitotic; Molecular Interaction; Muscle; Muscle Cells; Muscle Cells, Embryonic; Muscle Cells, Mature; Muscle Cells, Precursor; Muscle Fibers; Muscle Tissue; Mutagenesis, Site-Directed; Mutate; Myoblasts; Myocytes; Myotubes; P105-RB; P130; PP110; Play; Process; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Methylation; Proteins; RB1; RBL1 protein; RBL2; RBL2 gene; Rb Gene Product; Rb Protein; Rb1 Gene Product; Rb2; Recruitment Activity; Research; Research Proposals; Retinoblastoma Associated Protein; Retinoblastoma Protein; Rhabdomyocyte; Role; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Myocytes; Targeted DNA Modification; Targeted Modification; Targetings, Gene; Testing; Time; Tissue Growth; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Tumor Suppressor Proteins; Withdrawal; Work; bone; chromatin modification; experiment; experimental research; experimental study; functional genomics; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; histone modification; malignancy; neoplasm/cancer; ontogeny; p107 protein; p107 tumor suppressor protein; pRB; programs; recruit; research study; retinoblastoma like protein p107; retinoblastoma tumor suppressor; retinoblastoma-like 1 protein; social role; tumor; tumor suppressor; whole genome association studies; whole genome association study",Role of the pRB family in Quiescence and Differentiation,,67132,ZRG1,Special Emphasis Panel,,8,369171,
7747959,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM067152-08,,NIGMS:319127;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"JOHNSON, CARL HIRSCHIE;",1891333;,5R01GM067152,01/01/2003,12/31/2010,"3-D structure; 3-dimensional structure; 3D structure; Address; Affect; Algae, Blue-Green; Amaze; Anisotropy; Bacteria; Binding; Binding (Molecular Function); Biochemical; Biochemical Reaction; Biological Clocks; Biological Function; Biological Models; Biological Process; Blue-Green Bacteria; Body Tissues; Cells; Charge; Chemotherapy-Hormones/Steroids; Circadian Rhythms; Clock protein; Clock, Biologic; Cofactor Protein S; Compensation; Complex; Coupled; Crystallographies; Crystallography; Cyanobacterium; Cyanophyceae; Cyanophyta; Cyclicity; Depressed mood; Diurnal Rhythm; Electron Microscopy; Endocrine Gland Secretion; Enzymatic Reaction; Evaluation; Exhibits; FRET; Financial compensation; Fluorescence Resonance Energy Transfer; Gene Expression; Generations; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Grass, Bamboo; Health; Hormones; Human; Human, General; In Vitro; Intermediary Metabolism; Investigators; Jet Lag; Jet Lag Syndrome; Jetlag; Jetlag Syndrome; Knowledge; METBL; Macromolecular Structure; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Math Models; Measurement; Measures; Mental Health; Mental Hygiene; Metabolic; Metabolic Processes; Metabolism; Methods; Model System; Modeling; Models, Biologic; Molecular; Molecular Analysis; Molecular Interaction; Molecular Structure; Mutation; Nyctohemeral Rhythm; Organism; Output; Performance; Periodicity; Personal Satisfaction; Phase; Phosphorylation; Photosynthesis; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein S; Proteins; Psychological Health; Public Health; QOL; Quality of life; Regulation; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Resolution; Rhythmicity; Role; Sasa; Screening procedure; Sleep; Structure; Synechococcus; System; System, LOINC Axis 4; Temperature; Testing; Therapeutic Hormone; Time; Time Zone Change Syndrome; Time Zone Syndrome; Tissues; Twenty-Four Hour Rhythm; Vitamin K-Dependent Protein S; alertness; base; body clock; circadian; circadian clock; circadian pacemaker; circadian process; daily biorhythm; depressed; diurnal variation; gel electrophoresis; gene product; genome mutation; histidine kinase; improved; in vitro testing; in vivo; intermolecular interaction; internal clock; intervention development; living system; mathematical model; mathematical modeling; mutant; novel; programs; protein complex; protein function; protein-histidine kinase; public health medicine (field); reconstitute; reconstitution; sadness; screening; screenings; social role; therapy development; three dimensional structure; treatment development; well-being",Circadian Progams in Bacteria,,67152,ZRG1,Special Emphasis Panel,,8,319127,
7759173,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM067173-08,,NIGMS:284811;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,CHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"STAHL, SHANNON S;",2091224;,5R01GM067173,01/01/2003,12/31/2011,"Address; Aerobic; Air; Alcohols; Alkaloids; Alkenes; Amides; Amination; Amino Sugars; Area; Attention; Bears; Carbamates; Catalysis; Chemical Class, Alcohol; Chemicals; Chemistry; Chemistry, Organic; Claisen rearrangement; Complex; Coupling; Cyclization; Development; Eire; Exhibits; Gases; Goals; H2O2; History; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Imides; In Situ; Ireland; Ireland, Republic of; Irish Free State; Isocyanates; Kinetic; Kinetics; Lead; Ligands; Methods; Molecular; N element; N2 element; Nitrogen; O element; O2 element; Olefins; Organic Chemistry; Organic Synthesis; Outcome; Oxidants; Oxidizing Agents; Oxygen; Palladium; Pathway interactions; Pb element; Pd element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphates; Physical condensation; Play; Preparation; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pyrrolidines; Reaction; Reagent; Recording of previous events; Research; Rest; Role; Science of Chemistry; Structure; System; System, LOINC Axis 4; Therapeutic Agents; Ursidae; Ursidae Family; Work; aminosugar; base; carbene; carboxylate; catalyst; condensation; density; design; designing; electron acceptor; functional group; heavy metal Pb; heavy metal lead; inorganic phosphate; insight; methylene; methylene radical; oxidation; pathway; programs; public health relevance; pyrrolidine; social role; uptake",Palladium-Catalyzed Oxidative Amination of Alkenes,,67173,SBCB,Synthetic and Biological Chemistry B Study Section,,8,284811,
7752561,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM067542-08,,NIGMS:263991;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STORRS-MANSFIELD,UNITED STATES,PHARMACOLOGY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"ANDERSON, AMY C.;",2123356;,5R01GM067542,05/01/2003,12/31/2012,"5,6,7,8-Tetrahydrofolate[{..}]NADP+ oxidoreductase; AmB; Amphocil; Amphotec; Amphotercin B; Amphotercin B Deoxycholate; Amphotericin B; Animal Model; Animal Models and Related Studies; Animals; Antifungal Agents; Antifungal Drug; Assay; Azoles; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; C. albicans; C.albicans; Candida; Candida albicans; Candida glabrata; Cause of Death; Cells; Cessation of life; Chemistry, Pharmaceutical; Communicable Diseases, Emerging; Complex; DAP; DHFR; DHFR Inhibitor; Death; Diagnosis; Dihydrofolate Dehydrogenase; Dihydrofolate Reductase; Dihydrofolate Reductase Inhibitor; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 1.5.1.3; Emerging Communicable Diseases; Enzymes; Exhibits; Folic Acid Reductase; Fungicides, Therapeutic; Fungizone; Fungus Diseases; Generations; Goals; Human; Human, General; IC50; Industrial fungicide; Infection; Infectious Diseases, Emerging; Inhibitory Concentration 50; Lead; Libraries; Mammalian Cell; Man (Taxonomy); Man, Modern; Medicinal Chemistry; Metric; Minimum Inhibitory Concentration measurement; Minimum Inhibitory Concentrations; Molecular Interaction; Molecular Weight; Monilia; Mortality; Mortality Vital Statistics; Mycoses; Organism; Pb element; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Research; Resistance; Resolution; Sepsis; Series; Specificity; Structure; Tetrahydrofolate Dehydrogenase; Therapeutic; Time; Torulopsis glabrata; Toxic effect; Toxicities; Validation; Variant; Variation; analog; anti-fungal; anti-microbial agent; anti-microbial drug; antifungals; antimicrobial agent; antimicrobial drug; base; bloodstream infection; design; designing; diaminopyrimidine; fungal infection; fungicidal; fungicide; fungus; fungus infection; gene product; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; living system; meetings; member; model organism; pathogen; programs; public health relevance; resistance mechanism; resistant; resistant mechanism; success; therapeutic target",Targeting DHFR to Design Antimicrobial Agents, Systemic fungal infections have become a significant and devastating cause of severe illness and mortality. Infections caused by Candida glabrata have become increasingly prevalent and are resistant to many of the standard antifungal therapeutics. In this proposal we aim to use a structure-guided approach to synthesize inhibitors of dihydrofolate reductase (DHFR) effective against C. glabrata and to evaluate those inhibitors in cells and animals. We also aim to create a potent and selective broad spectrum inhibitor of C. glabrata and C. albicans DHFR that can be used prior to formal diagnosis of the Candida spp. infection.,67542,ZRG1,Special Emphasis Panel,,8,263991,
7760618,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM067645-07,,NIGMS:369171;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"KRAVITZ, EDWARD A;",1959040;,5R01GM067645,08/01/2003,01/31/2012,"3-D; 3-Dimensional; 4-Octopamine; Address; Aggression; Aggressive behavior; Amines; Animal Model; Animal Models and Related Studies; Animals; Arts; Behavior; Behavioral; Behavioral Genetics; Benzenemethanol, alpha-(aminomethyl)-4-hydroxy-; Biological; Biological Models; Brain; Cells; Chemotherapy-Hormones/Steroids; Complex; Conflict; Conflict (Psychology); Courtship; Decision Making; Drosophila; Drosophila genus; Drosophila melanogaster; Encephalon; Encephalons; Endocrine Gland Secretion; Female; Flies; Formosa; Fruit Fly, Drosophila; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Genes; Genetic; Genetic Determinants of Behavior; Genetic analyses; Genetics, Behavioral; Genome; Gustation; Hormones; Human; Human, General; Individual; Innate Behavior; Instinct; Investigators; Laboratories; Man (Taxonomy); Man, Modern; Maps; Methods; Model System; Modeling; Models, Biologic; Myxoid cyst; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Ganglion; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Norsympatol; Norsynephrine; Octopamine; Organism; Output; Pathway interactions; Pattern; Peptides; Plant Roots; Process; Receptor Protein; Relative; Relative (related person); Republic of China; Research Personnel; Research Support; Researchers; Resolution; Social Environment; Specific qualifier value; Specified; Synapses; Synaptic; System; System, LOINC Axis 4; Taiwan; Taste; Taste Perception; Therapeutic Hormone; Transgenic Organisms; Work; adult animal; alpha-(Aminoethyl)-4-hydroxybenzenemethanol; behavior genetics; court; experience; experimental analysis; fighting; fly; fruit fly; genetic analysis; genetic manipulation; living system; male; mature animal; model organism; mutant; neural circuit; neural circuitry; neuronal; norsynephrine receptor; octopamine receptor; p-Octopamine; para-Octopamine; pathway; presynaptic; public health relevance; receptor; response; root; sex; social; social climate; social context; socioenvironment; transgenic",Mutant Studies of Aggression in Drosophila,,67645,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,7,369171,
7771738,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM067735-07,,NIGMS:332640;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,082359691,US,MA,02138,HARVARD UNIVERSITY,"MICHAEL, MATTHEW ;",6805855;,5R01GM067735,05/01/2003,01/31/2013,"ATM Signaling Pathway; ATM activation; ATM pathway; ATM signaling; ATP-protein phosphotransferase; ATR; ATR protein kinase; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Assay; Ataxia Telangiectasia and Rad3 Related Protein; Attenuated; Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Bypass; C elegans; C.elegans; Caenorhabditis elegans; Cancer Cause; Cancer Drug; Cancer Etiology; Cell Communication and Signaling; Cell Cycle; Cell Cycle Checkpoint; Cell Division Cycle; Cell Division Process; Cell Signaling; Cells; Chemotherapeutic Agents, Neoplastic Disease; Chromosomal Breakage; Chromosomal Breaks; Chromosomal dislocation; Chromosomal translocation; Chromosome Break; Chromosome Breakage; Chromosomes; Complex; DNA; DNA Damage; DNA Injury; DNA Polymerase I; DNA Polymerase alpha; DNA Polymerases; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA polymerase eta; DNA-Dependent DNA Polymerase I; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7.7.7; Embryo; Embryonic; Event; FRAP-Related Protein-1; FRP1; Genetic; Genetic Materials; Genetic Screening; Genetic analyses; Genetic, Biochemical; Genome Stability; Goals; Human; Human, General; Intracellular Communication and Signaling; Klenow Fragment; Laboratories; Lead; Left; Lesion; Maintenance; Maintenances; Malignant Cell; Man (Taxonomy); Man, Modern; Materials, Genetic; Mediating; Molecular; Normal Cell; Ortholog; Orthologous Gene; POLH gene product; Pathway interactions; Pb element; Phase; Physiologic; Physiological; Play; Pol I; Polymerase; Process; Protein Kinase; Proteins; RAD30 gene product; RAD30A; Rad3 Related Protein; Rad30 protein; Recruitment Activity; Regulation; Replication Process; Replication-Associated Process; Role; S Period; S Phase; S phase (cell cycle); Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stability, Genomic; Stress; Synthesis Period; Synthesis Phase; System; System, LOINC Axis 4; Translocation, Genetic; Tumor-Specific Treatment Agents; Ubiquitin-Protein Ligase E3; XP-V gene product; XPV gene product; Xenopus; activation, Atm; anticancer agent; anticancer drug; base; biological signal transduction; cancer cell; chromosome dislocation; chromosome replication; chromosome translocation; egg; gene product; genetic analysis; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; meetings; novel; pathway; phosphorylase b kinase kinase; poleta; public health relevance; recruit; repair; repaired; response; social role; ubiquitin ligase; ubiquitin-protein ligase",Replication checkpoint activation and silencing," Project Narrative DNA damage is a serious impediment to chromosome replication, a fundamental component of the process of cell division. When DNA damage is encountered during chromosome replication, it will stall the DNA polymerases that are responsible for duplication of the genetic material. This stalling can have severe consequences for the stability of the genome, as a stalled polymerase that is left unresolved can cause the replication process to collapse, and the chromosome to break. The repair of broken chromosomes can be imperfect, and can than thereby result in the chromosome translocations that are known to cause cancer. In this proposal, we focus on two cellular pathways that help cells deal with stalled polymerases. One is a signaling pathway, and we will study how this signaling pathway recognizes stalled polymerases and, how it is activated by them. The other pathway involves a specialized DNA polymerase that can replicate DNA even when it is damaged. We will study the regulation of this polymerase, and the ability of this polymerase to influence signaling that is derived from stalled replication. These studies will help us understand how cells manage stalled replication, and could form the basis for newer and more effective anti-cancer drugs.",67735,ZRG1,Special Emphasis Panel,,7,332640,
7741237,R01,GM,5,,12/01/2009,11/30/2010,PA-07-070,5R01GM067966-06,,NIGMS:307030;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BUFFALO,UNITED STATES,BIOCHEMISTRY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"O'BRIAN, MARK R;",1933653;,5R01GM067966,01/01/2004,11/30/2012,"Address; Anabolism; Autoregulation; Bacteria; Biochemical Genetics; Biological Models; Bradyrhizobium; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cues; Data; Disease; Disorder; Environment; Eukaryota; Eukaryote; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Gene Expression; Gene Targeting; GeneHomolog; Genes; Genetic, Biochemical; Heme; Heme Iron; Heme Synthetase; Heme b; Homeostasis; Homolog; Homologous Gene; Homologue; Infection; Intermediary Metabolism; Iron; METBL; Mediating; Metabolic Processes; Metabolism; Model System; Modeling; Models, Biologic; Molecular; Normal Cell; Operon; Organism; Outcome; Pathogenesis; Pathway interactions; Physiological Homeostasis; Porphyrin-Metal Chelatase; Proteobacteria; Protoheme; Protoheme Ferro-Lyase; Protoheme IX; Protoporphyrins; Purple Bacteria; Reaction; Regulation; Regulatory Protein; Role; Site; Source; Subcellular Process; Symbiosis; Targetings, Gene; Toxic effect; Toxicities; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Work; biosynthesis; commensalism; disease/disorder; eukaryotida; experiment; experimental research; experimental study; ferrochelatase; ferroheme; genetic regulatory protein; heme a; heme biosynthesis; interest; iron metabolism; living system; novel; pathogen; pathogenic bacteria; pathway; protein function; public health relevance; regulatory gene product; research study; response; social role; success",Regulation of Bacterial Heme Metabolism," PROJECT NARRATIVE Although invasion of higher organisms by beneficial and disease-causing bacteria results in very different outcomes from the host perspective, aspects of pathogenesis and symbiosis can be remarkably similar at the molecular level. The symbiotic bacterium Bradyrhizobium japonicum is experimentally more tractable than related pathogens, and is therefore a good model system. We are studying novel mechanisms of bacterial heme and iron metabolism in B. japonicum towards the end of understanding molecular strategies that bacteria employ for infection and adaptation.",67966,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,6,307030,
7753173,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM068648-05,,NIGMS:241043;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IOWA CITY,UNITED STATES,BIOCHEMISTRY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"ELCOCK, ADRIAN HAMILTON;",7037166;,5R01GM068648,01/01/2006,12/31/2010,"ATP-protein phosphotransferase; Address; Adopted; Affect; Affinity; Agreement; Assay; Attention; Benchmarking; Best Practice Analysis; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Calorimetry; Collaborations; Combining Site; Complex; Computer Simulation; Computerized Models; Computing Methodologies; Data; Disease; Disorder; Drugs; EC 2.7; Electrostatics; Entropy; Free Energy; Goals; Human; Human, General; Investigators; Kinases; Left; Ligands; Location; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Medication; Method LOINC Axis 6; Methodology; Methods; Models, Computer; Molecular Interaction; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Programs (PT); Programs [Publication Type]; Protein Kinase; Protein Kinase Inhibitors; Proteins; Protocol; Protocols documentation; Reactive Site; Receptor Protein; Relative; Relative (related person); Research; Research Personnel; Researchers; SB 203580; SB203580; Simulation, Computer based; Site; Sodium Chloride; Sodium chloride (NaCl); Specificity; Structure; Testing; Therapeutic; Thermodynamic; Thermodynamics; Titrations; Transphosphorylases; Washington; Work; analog; cancer type; computational methodology; computational methods; computational modeling; computational models; computational simulation; computational studies; computer based models; computer methods; computer studies; computerized modeling; computerized simulation; design; designing; disease/disorder; drug/agent; enthalpy; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; in silico; inhibitor; inhibitor/antagonist; interest; kinase inhibitor; mutant; phosphorylase b kinase kinase; professor; programs; protein kinase inhibitor; receptor; research study; salt; small molecule; therapeutic target; virtual simulation",Computational and experimental studies of targets of protein kinase inhibitors,,68648,ZRG1,Special Emphasis Panel,,5,241043,
7762156,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM068956-08,,NIGMS:449013;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"DANUSER, GAUDENZ ;SORGER, PETER KARL (contact);",1887133 (contact);6624757;,5R01GM068956,06/15/2003,12/31/2011,"Anaphase; Animal Welfare; Bibliography; Binding; Binding (Molecular Function); Cells; Centromere; Chromosome Segregation; Chromosomes; Country; DNA; DNA Alteration; DNA mutation; Data; Deoxyribonucleic Acid; Descriptor; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Gene Alteration; Gene Mutation; Genetic mutation; Genome Instability; Genomic Instability; Goals; Heterogeneity; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kinetochores; Knowledge; Learning; Life; Link; Mechanics; Mediating; Metaphase; Methods; Micro-tubule; Microtubules; Mitotic Anaphase; Mitotic Metaphase; Mitotic spindle; Modeling; Molecular Genetic; Molecular Genetics; Molecular Interaction; Motor; Names; Organism; Polymers; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resource Sharing; Resources; Role; S cerevisiae; Saccharomyces cerevisiae; Sequence Alteration; Sister Chromatid; Source; Structure; Vertebrate Animals; Vertebrates; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; YeastModel; Yeasts; abstracting; base; chromosome movement; daughter cell; experiment; experimental research; experimental study; expiration; human subject; living system; man; man's; programs; protein complex; research study; social role; vertebrata; yeast protein",Computation and Mechanical Modeling of Chromosome Dynamics,,68956,MABS,Modeling and Analysis of Biological Systems Study Section,,8,449013,
7777427,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM069454-06,,NIGMS:240471;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,BIOCHEMISTRY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KIMBLE, JUDITH ;",1928852;,5R01GM069454,02/01/2004,12/31/2012,"ATP-RNA Adenylyltransferase; ATP[{..}]polynucleotide adenylyltransferase; Address; Animals; Biological Function; Biological Process; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cancer Cause; Cancer Etiology; Cancers; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Fate Control; Cell Fate Regulation; Cell Signaling; Cells; Cues; Development; Differentiation and Growth; Difficulty conceiving; Distal; Dose; EC 2.7.2-; ERK 2; Event; Extracellular Signal-Regulated Kinase 2; Extracellular Signal-Regulated Kinases; Flies; Fogs; Foundations; Gametes; Germ Cells; Germ-Line Cells; Health; Human; Human, General; Individual; Infertility; Intracellular Communication and Signaling; Learning; Light; Link; M Phase; M phase (cell cycle); MAP Kinase 1; MAP Kinase 2; MAP kinase; MAPK; MAPK1; MAPK1 Mitogen-Activated Protein Kinase; MAPK2 Mitogen-Activated Protein Kinase; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Meiosis; Mitogen Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 2; Mitogen-Activated Protein Kinases; Mitosis; Mitosis Stage; Modeling; Molecular; Mother Cells; Nematoda; Nematodes; Oocytes; Ovocytes; P42MAPK; PRKM1; Photoradiation; Poly A Polymerase; Polyadenylate Polymerase; Polyadenylate Synthetase; Polynucleotide Adenylyltransferase; Progenitor Cells; Proteins; RNA-Binding Proteins; Regenerative Medicine; Regulation; Reproductive Biology; Reproductive Cells; Research; Riboadenylate Transferase; Role; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Source; Sperm; Spermatozoa; Stem cells; Tissues; Work; base; biological signal transduction; combinatorial; experiment; experimental research; experimental study; fly; gene product; infertile; initial cell; injured; malignancy; meiotic; neoplasm/cancer; notch; notch protein; notch receptors; p42 MAP Kinase; p42 MAPK; p42(Mapk) Kinase; p42(Mitogen-Activated Protein Kinase); public health relevance; research study; response; roundworm; sexual cell; social role; sperm cell; stem cell niche; unable to bear children; zoosperm",Regulation of germline proliferation and differentiation," Project narrative This proposal investigates the molecular regulation of germline stem cells, germline transit-amplifying cells and the sperm/oocyte decision. Regulators of these germline fates, when defective, cause cancer or infertility, two major health problems. Moreover, germ cells may well be the ultimate source of stem cells for regenerative medicine to replace tissues in diseased or injured individuals.",69454,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,6,240471,
7762816,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM069670-06,,NIGMS:347229;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"CHANG, FRED ;",1889127;,5R01GM069670,02/01/2005,01/31/2013,"Actin Filaments; Actins; Animal Model; Animal Models and Related Studies; Behavior; Binding; Binding (Molecular Function); Binding Proteins; Cancers; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Process; Cell Shape; Cell division; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Migration; Cellular Physiology; Cellular Process; Chromosome Segregation; Collection; Cytoskeletal System; Cytoskeleton; Elements; Event; Exhibits; Filament; Fission Yeast; Generalized Growth; Genetic; Goals; Grant; Growing End of the Microtubule; Growth; In Vitro; Interphase; Kinetochores; Knowledge; Ligand Binding Protein; Link; Location; M Phase; M phase (cell cycle); MAP; Malignant Neoplasms; Malignant Tumor; Micro-tubule; Microfilaments; Microtubule Bundle; Microtubule-Associated Proteins; Microtubules; Mitosis; Mitosis Stage; Mitotic spindle; Modeling; Molecular; Molecular Interaction; Motility; Motility, Cellular; Myofilaments; Nuclear; Nucleus; Play; Plus End of the Microtubule; Position; Positioning Attribute; Process; Regulation; Role; S pombe; Schizosaccharomyces pombe; Site; Structure; Subcellular Process; Testing; Tissue Growth; Tubulin; Work; Yeast, Fission; cell motility; human disease; intracellular skeleton; malignancy; migration; model organism; neoplasm/cancer; ontogeny; prevent; preventing; public health relevance; social role",Microtubule Organization and Nuclear Positioning, Project Narrative Microtubules are dynamic filaments responsible for cell division and determination of cell shape and function. In this proposal we will determine how the growth and shrinkage of microtubules are regulated. These studies will provide greater understanding of how mitotic spindles work and will be relevant for human diseases such as cancer.,69670,CSF,Cell Structure and Function Study Section,,6,347229,
7799872,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM069753-06,,NIGMS:430347;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MINNEAPOLIS,UNITED STATES,PHARMACOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"TRACY, TIMOTHY S.;",1907140;,5R01GM069753,08/01/2004,01/31/2013,"1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-; 2,4-Imidazolidinedione, 5,5-diphenyl-; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid; 5,5-Diphenylhydantoin; Affect; Age; Alleles; Allelomorphs; Ansaid; CPC9; CPD6; CYP2C10; CYP2C9; CYP2C9 gene; CYP2D; CYP2D6; CYP2D6 gene; CYP2DL1; Characteristics; Clinical; Clinical Research; Clinical Study; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Data; Development; Dilantin; Diphenylhydantoin; Dose; Drug Exposure; Drug Interactions; Drug Therapy; Drugs; Enzymes; Exhibits; Fenitoin; Flubiprofen; Fluconazole; Flurbiprofen; Fluriproben; Gender; Gene variant; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetic defect; Genotype; Goals; Grant; Human; Human, General; In Vitro; Individual; Intermediary Metabolism; Laboratories; Lead; METBL; Man (Taxonomy); Man, Modern; Medication; Metabolic; Metabolic Processes; Metabolism; Method LOINC Axis 6; Methodology; Modeling; Mutation; Outcome; P450; P450 MP-4; P450 PB-1; P450-DB1; P450C2D; P450IIC9; Patients; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenetics; Pharmacotherapy; Phenytoin; Polymorphism (Genetics); Polymorphism, Genetic; Position; Positioning Attribute; Predisposition; Race; Racial Group; Recommendation; Research; Stocks, Racial; Susceptibility; System; System, LOINC Axis 4; Therapeutic Index; Toxic effect; Toxicities; Variant; Variation; Variation (Genetics); Work; allelic variant; alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; base; computer based prediction; diflucan; drug metabolism; drug/agent; genome mutation; heavy metal Pb; heavy metal lead; improved; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; interest; pharmacokinetic model; polymorphism; predictive modeling; public health relevance",Pharmacogenetics and Drug Interactions," A person's genetic makeup can affect drug disposition and action, as well as the susceptibility to drug interactions. Improved understanding of these genetic changes and their effects on drug disposition will lead to improved drug therapy and better management of drug-drug interactions.",69753,ZRG1,Special Emphasis Panel,,6,430347,
7883222,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM069773-07,,NIGMS:269272;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,CHEMISTRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"TOR, YITZHAK ;",1968538;,5R01GM069773,01/01/2004,01/31/2012,"7,8-dihydro-8-oxoguanosine; 8-hydroxyguanosine; 8-oxo-7,8-dihydroguanosine; 8-oxoG; 8-oxoGuo; 8-oxoguanosine; AIDS Drugs; Absorption; Anti-AIDS Agents; Anti-AIDS Drugs; Anti-HIV Agents; Anti-HIV Drugs; Anti-Human Immunodeficiency Virus Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Assay; Behavior; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Function; Biological Process; Biology; Cancer Induction; Characteristics; Complement; Complement Proteins; DNA; DNA Modification; DNA Modification Process; DNA lesion; Data; Deoxyribonucleic Acid; Detection; Development; Disease; Disorder; Fluorescence; Gene Products, RNA; Generations; Goals; Guanosine, 7,8-dihydro-8-oxo-; Health; Human; Human, General; Investigation; Lectin, Castor Bean; Lectin, Ricinus; Man (Taxonomy); Man, Modern; Miscellaneous Antibiotic; Modification; Nature; Nucleic Acids; Nucleosides; Nucleotides; Oligo; Oligonucleotides; Phase; Play; Process of absorption; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; RCA 60; RCA60; RNA; RNA, Non-Polyadenylated; Reporting; Research; Resistance; Ribonucleic Acid; Ribosomes; Ricin; Ricinus Communis Agglutinin II; Ricinus Toxin; Role; Shapes; Site; Solid; Structure; Therapeutic Agents; Toxin; Work; absorption; analog; antiAIDS agent; base; carcinogenesis; design; designing; disease/disorder; drug discovery; gene product; improved; new approaches; new diagnostics; next generation diagnostics; novel; novel approaches; novel diagnostics; novel strategies; novel strategy; nucleic acid structure; nucleobase; nucleobase analog; nucleoside analog; pathogen; programs; public health relevance; quantum; resistant; social role; tool; trend",Fluorescent Nucleosides and Oligonucleotides,,69773,SBCA,Synthetic and Biological Chemistry A Study Section,,7,269272,
7763235,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM069802-05,,NIGMS:281256;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PROVIDENCE,UNITED STATES,BIOCHEMISTRY,01,001785542,US,RI,02912,BROWN UNIVERSITY,"SERIO, TRICIA R;",2093214;,5R01GM069802,02/01/2006,01/31/2011,"Acetyltransferase; Adopted; Assay; Baker's Yeast Proteins; Behavior; Bioassay; Biochemical; Biogenesis; Biologic Assays; Biologic Phenomena; Biological; Biological Assay; Biological Function; Biological Models; Biological Phenomena; Biological Process; Cells; Cellular Regulation; Chaperone; Chemicals; Codon, Stop; Codon, Termination; Codon, Terminator; Collection; Complex; Cytoplasm; Development; Disease Progression; Eukaryota; Eukaryote; Event; Foundations; Glean; Goals; In Vitro; Individual; Investigation; Knowledge; Label; Link; Mammalia; Mammals; Mammals, General; Methods; Model System; Models, Biologic; Molecular; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Nucleic Acids; Origin of Life; PSI; Phenotype; Physiologic; Physiological; PrP Proteins; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion Proteins; Prion-Induced Disorder; Prions; Process; Protein Structure Initiative; Proteins; Reading; Regulation; Role; S cerevisiae Proteins; Saccharomyces cerevisiae Proteins; Spongiform Encephalopathies, Transmissible; Stimulus; Stop Signal, Translation; System; System, LOINC Axis 4; Terminator Codon; Trans-Acting Factors; Trans-Activators; Transactivators; Translations; Transmissible Dementias; Transmission; Variant; Variation; Work; base; cell growth regulation; conformation; conformational state; conformer; eukaryotida; flexibility; gene product; in vivo; insight; non-prion; novel; physical state; prion hypothesis; prion-based; protein function; protein structure; protein-only hypothesis; social role; spongiform degeneration; spongiform encephalopathy; sup35; trait; trans acting factor (genetic); transmission process",Prion Cycle Regulation In Vivo,,69802,MBPP,Membrane Biology and Protein Processing Study Section,,5,281256,
7778343,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM069950-07,,NIGMS:325354;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HANOVER,UNITED STATES,GENETICS,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"CONRADT, BARBARA ;",7651114;,5R01GM069950,01/01/2004,12/31/2012,"Adaptor Protein; Adaptor Signaling Protein; Affect; Apoptosis; Apoptosis Pathway; Apoptotic; Autoimmune Diseases; Autoregulation; Behavior; Biological Models; C elegans; C.elegans; Caenorhabditis elegans; Cancer stem cell; Cell Death; Cell Death, Programmed; Cell division; Cells; Cessation of life; Chaperone; Coupled; Coupling; Data; Daughter; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Embryo Development; Embryogenesis; Embryonic Development; Ensure; Exclusion; Funding; GSK-3; Gene Transcription; Generations; Genes; Genetic; Genetic Screening; Genetic Transcription; Glycogen Synthase Kinase 3; Goals; Health; Homeostasis; Human; Human, General; Induction of Apoptosis; Kinases; Link; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Model System; Models, Biologic; Molecular; Molecular Chaperones; Mother Cells; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Oncogenesis; Pathway interactions; Phosphotransferases; Physiological Homeostasis; Play; Process; Progenitor Cells; Proteins; RNA Expression; Regulation; Role; SIS; Sister; SnaH protein; Snails; Stem cells; Testing; Transcription; Transcription Corepressor; Transcription Regulation; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Control; Transcriptional Corepressor; Transcriptional Regulation; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transphosphorylases; Ubiquitin Protein Ligase; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligase E3; Work; autoimmune disorder; base; cancer type; daughter cell; disease/disorder; gene product; gsk-3 Gene Product; necrocytosis; neuroblast; neurodegenerative illness; neuronal; pathway; prevent; preventing; public health relevance; roundworm; sna gene product; sna protein; snail gene product; snail protein; social role; transcription factor; tumorigenesis; ubiquitin-protein ligase",Analysis of Cell Death Regulation in C. elegans," PROJECT NARRATIVE Apoptosis is an evolutionary conserved process that plays important roles during embryonic development and in the postembryonic maintenance of cellular homeostasis. Its deregulation has been implicated in a variety of diseases in humans most notably various types of cancers, autoimmune disorders and neurodegenerative diseases; however very little is known thus far about how apoptosis is normally controlled. We discovered that apoptosis can directly be controlled by asymmetric cell division, which represents a new concept in apoptosis regulation. Therefore, the proposed studies will contribute to our basic understanding of developmental health disorders and are specifically relevant to understanding the behavior of cancer stem cells and, hence, tumorigenesis.",69950,DEV1,Development - 1 Study Section,,7,325354,
7788109,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM071036-06,,NIGMS:283488;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,GALVESTON,UNITED STATES,BIOCHEMISTRY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"RAMANA, KOTA VENKATA;",7758977;,5R01GM071036,02/01/2005,01/31/2011,"3'5'-cyclic ester of AMP; 4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; API; Ablation; Activator Protein-1; Active Oxygen; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Aldehyde Reductase; Aldehydes; Alditol[{..}]NAD(P)+ 1-oxidoreductase; Aldose Reductase; Apoptosis; Apoptosis Pathway; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Blood Serum; Blood Vessels; Body Tissues; COX-2 protein; COX2; COX2 enzyme; CSIF; CSIF-10; Cachectin; Cachectin-Tumor Necrosis Factor; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular Expansion; Cellular Growth; Cyclic AMP; Cyclo-Oxygenase-2; Cyclooxygenase; Cytokine Signal Transduction; Cytokine Signaling; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytokines, Chemotactic; Dephosphorylation; Development; Differentiation Factor, B-Cell; Dinoprostone; Disease; Disorder; Doctor of Philosophy; Drug Metabolic Detoxication; Endotoxins; Enhancer-Binding Protein AP1; Enzymes; Event; Extracellular Signal-Regulated Kinase Gene; GFAC; Gastrointestinal Tract, Small Intestine; Generalized Growth; Generations; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HPGF; Healed; Heart; Hepatocyte Nitric Oxide Synthase; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; Hybridoma Growth Factor; Hyperglycemia; I Kappa B A; I Kappa B-Alpha; I kappa B-alpha protein; IFN-beta 2; IFNB2; IKB-Alpha; IKBA; IKappaB; IKappaB-Alpha; IKappaB/MAD-3; IL-10; IL-6; IL10; IL10A; IL6 Protein; INFLM; INOS; IP injection; IkappaBalpha; Immunoglobulin Enhancer-Binding Protein; In Vitro; Inducible Nitric Oxide Synthase; Infection; Inflammation; Inflammatory; Inflammatory Response; Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha; Injections, Intraperitoneal; Injury; Intercrines; Interleukin 10 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin-10; Interleukin-6; Intermediary Metabolism; Intervention; Intervention Strategies; Intestines, Small; Intracellular Communication and Signaling; Intraperitoneal Injections; Isoenzymes; Isoforms; Isozymes; Kidney; LPS; Lead; Lecithinases; Leiomyocyte; Lipid Peroxidation; Lipids; Lipopolysaccharides; Liver; Lytotoxicity; MAD-3; MAD-3 protein; MAD3; MAD3 inhibitor; MAP Kinase Gene; MAPI; MAPK; METBL; MGI-2; Macrophage Nitric Oxide Synthase; Macrophages, Peritoneal; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Metabolic; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolic Processes; Metabolism; Metabolism of Toxic Agents; Mice; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Molecular Interaction; Murine; Mus; Myeloid Differentiation-Inducing Protein; Myocytes, Smooth Muscle; NADPH Oxidase; NF-Kappa B Inhibitor Alpha; NF-kB; NF-kappa B; NF-kappaB; NF-kappaB inhibitor alpha; NFKB; NFKBI; NFKBIA; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide Synthase 2A; Nuclear Factor Kappa-B Inhibitor; Nuclear Factor kappa B; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor; Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha; Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha; Nuclear Transcription Factor NF-kB; Oxidation-Reduction; Oxygen Radicals; PGE2; PGE2 alpha; PGE2alpha; PGH Synthase 2; PGHS-2; PGHS2; PHS II; PKC; PTGS2; Participant; Pathway interactions; Pb element; Peptide Biosynthesis, Ribosomal; Peritoneal Macrophages; Ph.D.; PhD; Phospholipase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphorylation; Physiologic; Physiological; Plasmacytoma Growth Factor; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pro-Oxidants; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin-Endoperoxide Synthase 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Dephosphorylation; Protein Isoforms; Protein Kinase C; Protein Phosphorylation; Protein Synthesis, Ribosomal; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Reactive Oxygen Species; Receptor Protein; Redox; Regulation; Resolution; Reticuloendothelial System, Spleen; Role; SIS cytokines; Sepsis; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Small Intestines; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spleen; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Testing; Therapeutic Intervention; Tissue Growth; Tissues; Toxic effect; Toxicities; Transcription Factor AP-1; Transcription Factor NF-kB; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Urinary System, Kidney; Vascular Endothelial Cell; adduct; adenosine 3'5' monophosphate; alkaline protease inhibitor; arterial lesion; atheromatosis; atherosclerotic vascular disease; attenuation; base; biological signal transduction; bloodstream infection; body system, hepatic; cAMP; cell growth; chemoattractant cytokine; chemokine; cultured cell line; cyclo-oxygenase II; cyclooxygenase 2; cytokine; cytotoxic; cytotoxicity; detoxification; disease/disorder; experience; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; healing; heavy metal Pb; heavy metal lead; human NOS2A protein; human TNF protein; hyperglycemic; iNOS enzyme; in vivo; inhibitor; inhibitor/antagonist; injured; interferon beta 2; intervention therapy; interventional strategy; kappa B Enhancer Binding Protein; macrophage; malignancy; membrane structure; microbial alkaline proteinase inhibitor; neoplasm/cancer; nitric oxide synthase, Type II; novel; novel therapeutic intervention; nuclear factor kappa beta; ontogeny; organ system, hepatic; oxidation reduction reaction; p40 protein (IkappaB-alpha); pathway; prevent; preventing; prostaglandin H synthase-2; protein synthesis; receptor; renal; repair; repaired; siRNA; small bowel; social role; transcription factor; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; vascular",Aldose Reductase: A Regulator of Inflammatory Signals,,71036,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,6,283488,
7756627,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM071775-05,,NIGMS:220617;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MIAMI,UNITED STATES,NEUROLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"BARRIENTOS, ANTONI ;",7859116;,5R01GM071775,02/01/2006,01/31/2011,"Affinity Chromatography; Assay; Binding Proteins; Bioassay; Biochemical Genetics; Biogenesis; Biologic Assays; Biological Assay; COX1; COX3; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cells; Chromatography, Affinity; Co-Immunoprecipitations; Complex; Cytochrome Oxidase; Cytochrome Oxidase Deficiency; Cytochrome-c Oxidase (Complex IV); Cytochrome-c Oxidase Deficiency; Defect; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Electron Transport Complex IV; Encephalomyelitis, Subacute Necrotizing; Encephalomyelopathy, Subacute Necrotizing; Encephalopathies; Encephalopathy, Subacute Necrotizing; Enzymes; Event; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; GeneHomolog; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic, Biochemical; Health; Homolog; Homologous Gene; Homologue; Human; Human, General; Hybrids; Intermediary Metabolism; Leigh Disease; Leigh Syndrome; Ligand Binding Protein; METBL; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Membrane; Messenger RNA; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mitochondria; Modeling; Molecular; Molecular Weight; Muscle Weakness; Muscular Weakness; Mutation; Nature; Nuclear; Origin of Life; Oxidases; PCOX1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS; PTGS1; PTGS1 gene; Patients; Photometry/Spectrum Analysis, Mass; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; RNA, Messenger; Regulation; Reporting; Research; Respiration; Role; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; System; System, LOINC Axis 4; Techniques; Testing; Time; Translations; Yeasts; affinity purification; base; cell type; clinical phenotype; cross-link; crosslink; cytochrome c oxidase; disease/disorder; gene product; genome mutation; mRNA; membrane structure; mitochondrial; mutant; polypeptide; programs; respiratory mechanism; social role; temperature sensitive mutant",CYTOCHROME C OXIDASE IN HEALTH AND DISEASE,,71775,BBM,Biochemistry and Biophysics of Membranes Study Section,,5,220617,
7751916,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM072566-06,,NIGMS:311285;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,CHEMISTRY,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"JAMISON, TIMOTHY F;",1975023;,5R01GM072566,01/17/2005,12/31/2012,"Acids; Affect; Alcohol, Methyl; Biogenesis; Biological Factors; Brevenal; Carbinol; Collaborations; Cystic Fibrosis; Development; Disease; Disorder; Environment; Epoxides; Epoxy Compounds; Factor, Biologic; Goals; Gymnodinium breve toxin; Heating; Hydrogen Oxide; Knowledge; Methanol; Methods; Mind; Mucoviscidosis; Natural Products; Origin of Life; Pattern; Preparation; Reaction; Structure; System; System, LOINC Axis 4; Testing; Therapeutic; Variant; Variation; Water; Wood Alcohol; aqueous; base; brevetoxin; design; designing; disease/disorder; experiment; experimental research; experimental study; flexibility; functional group; gambierol; improved; method development; methyl group; novel; public health relevance; red tide toxin; research study",Synthetic strategies based on epoxide-coupling reactions," Project Narrative The unifying theme this proposal is polyether synthesis via epoxide-opening cascades conducted in aqueous environments. The methods constitute a new strategy for the synthesis of polyethers of the ""ladder"" structural class (similar to brevetoxin and other ""Red Tide"" toxins), and will be used to prepare compounds of this type that are of biomedical relevance (including gambierol and gymnocin B) or have therapeutic potential (including brevenal). The diseases targeted include cystic fibrosis.",72566,SBCA,Synthetic and Biological Chemistry A Study Section,,6,311285,
7796841,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM072705-15,,NIGMS:311337;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STANFORD,UNITED STATES,CHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"KOOL, ERIC T.;",1883864;,5R01GM072705,08/01/1995,01/31/2013,"ATP[{..}]thymidine 5'-phosphotransferase; Active Sites; Address; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Area; Base Pairing; Biochemistry; Biological; Biological Function; Biological Process; Biology; Cancer Genes; Cancer Induction; Cancer Treatment; Cancer-Promoting Gene; Cancers; Cells; Chemistry; Chemistry, Biological; Communicable Diseases; Complex; DNA; DNA Damage; DNA Injury; DNA Polymerases; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Data; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxynucleotide-triphosphate[{..}]DNA deoxynucleotidyltransferase (RNA-directed); Deoxypyrimidine Kinase; Deoxyribonucleic Acid; Deoxythymidine Kinase; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug resistance; Drugs; EC 2.7; EC 2.7.1.21; EC 2.7.7.49; EC 2.7.7.7; Electronics; Electrostatics; Enzymes; Family; Food; Funding; Future; Gene Products, RNA; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Health; Human; Human, General; Image; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intermediary Metabolism; Investigation; Kinases; Knowledge; Lead; Link; METBL; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mediating; Medical; Medication; Messenger RNA; Metabolic Pathway; Metabolic Processes; Metabolism; Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids; Molecular; Molecular Biology, Mutagenesis; Muscle Rigidity; Mutagenesis; Mutate; Mutation; Nucleic Acids; Nucleosides; Nucleotide Synthesis; Nucleotides; Oncogenes; Outcome; Oxopurines; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Polymerase; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Phosphorylation; Proteins; Purinones; Quelling; RNA; RNA Interference; RNA Sequences; RNA Silencing; RNA Silencings; RNA Transcriptase; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Dependent DNA Polymerase; RNA-Directed DNA Polymerase; RNAi; Radiolabeled; Reading; Research; Research Design; Retroviridae; Retroviruses; Reverse Transcriptase; Revertase; Ribonucleic Acid; Rigidity; Rigidity, Muscular; Science of Chemistry; Sequence-Specific Posttranscriptional Gene Silencing; Sequences, RNA; Shapes; Sites, Active; Specificity; Structure; Study Type; Testing; Therapeutic; Thymidine Kinase; Toxic effect; Toxicities; Transforming Genes; Transphosphorylases; Uncertainty; Virus-Retrovirus; Work; analog; anticancer therapy; base; biological research; biological systems; cancer therapy; carcinogenesis; design; designing; disease/disorder; doubt; drug resistant; drug/agent; experiment; experimental research; experimental study; flexibility; gene product; genome mutation; heavy metal Pb; heavy metal lead; imaging; improved; insight; mRNA; malignancy; neoplasm/cancer; new diagnostics; next generation diagnostics; novel diagnostics; nucleobase; nucleoside analog; nucleotide metabolism; oxidative damage; pathway; public health relevance; radiolabel; radiotracer; repair; repair endonuclease; repair enzyme; repaired; research study; resistance to Drug; resistant to Drug; study design; tool; tumor; uptake",Probing Nucleotide Recognition in the Genetic Information Pathway," Narrative / Relevance We propose to study how the four nucleic acid bases of DNA and RNA are discriminated from one another in the biological pathways that involve this genetic information. This will be done by design and study of modified versions of these bases, and their function in these pathways. The work is important because it provides basic information about how mutations arise in DNA, and suggests new strategies for increasing activity and lowering toxicity of potential nucleotide- based drugs.",72705,ZRG1,Special Emphasis Panel,,15,311337,
7762702,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM072805-06,,NIGMS:337212;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"MOAZED, DANESH ;",1944254;,5R01GM072805,02/01/2005,01/31/2013,"Address; Base Pairing; Biochemical; Bypass; Cell Nucleus; Cells; Chaperone; Chromatin; Chromosomes; Cleaved cell; Complex; DICER1; DICER1 Protein; DICER1 protein, human; DISSEC; DNA Sequence; Dcr-1 Homolog; Dicer; Dicer1, Dcr-1 homolog (Drosophila) protein, human; Dissection; Double-Stranded RNA; EC 2.1.1; EC 2.7.7.48; EC 3.1.26.-; Endoribonuclease Dicer; Enzymes; Fission Yeast; Functional RNA; Gene Inactivation; Gene Products, RNA; Gene Silencing; Gene Transcription; Generations; Genetic Transcription; Goals; HERNA; HERNA protein, human; Helicase with RNase Motif; Helicase-MOI; Heterochromatin; Histone H3; Histones; Homolog of Drosophila Dicer; Human; Human, General; In Vitro; Intervention; Intervention Strategies; K12H4.8-Like; KIAA0928; Knowledge; L-Lysine; Laboratories; Link; Lysine; Man (Taxonomy); Man, Modern; Mediating; Methods; Methylation; Methyltransferase; Molecular; Molecular Chaperones; Non-Coding; Non-Coding RNA; Nucleic Acids; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (RNA-directed); Nucleus; Pathway interactions; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Methylation; Proteins; Quelling; RNA; RNA Binding; RNA Expression; RNA Interference; RNA Interference Pathway; RNA Metabolism[{..}] Processing and Transport; RNA Precursors; RNA Processing; RNA Replicase; RNA Sequences; RNA Silencing; RNA Silencings; RNA Splicing; RNA chemical synthesis; RNA polymerase III transcription; RNA synthesis; RNA, Double-Stranded; RNA, Non-Polyadenylated; RNA, Small Interfering; RNA-Dependent RNA Polymerase; RNA-Directed RNA Polymerase; RNAi; Recruitment Activity; Regulation; Ribonucleic Acid; Role; S pombe; Schizosaccharomyces pombe; Sequence-Specific Posttranscriptional Gene Silencing; Sequences, RNA; Site; Small Interfering RNA; Splicing; Testing; Therapeutic; Transcript; Transcription; Transcription, Genetic; Transgenes; Viral; Work; Yeast, Fission; base; cancer cell differentiation; cleaved; design; designing; dsRNA; gene product; histone H3 methyltransferase; histone methylase; histone methyltransferase; human DICER1 protein; in vivo; interventional strategy; methylase; mutant; novel; pathway; preference; programs; protein protein interaction; public health relevance; reconstitute; reconstitution; recruit; siRNA; social role; transcription termination; transmethylase",RNAi-Mediated Heterochromatin Assembly," This project addresses the role of RNA interference (RNAi), a conserved RNA silencing pathway, in gene silencing in the nucleus. Components of this pathway are involved in regulation of cell differentiation and cancer in humans. A basic understanding of the role of RNAi in gene silencing will not only provide a frame work for understanding how the process can fail, but also provides the substrate and knowledge to design therapeutic strategies based on intervention.",72805,MGB,Molecular Genetics B Study Section,,6,337212,
7926966,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM073020-06,,NIGMS:344149;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MILLER, WALTER L.;",1892272;,5R01GM073020,02/01/2005,01/31/2013,"ADRGND; Accounting; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Adrenal Glands; Adrenals; Affect; Alleles; Allelomorphs; Amino Acid Sequence; Amino Acids; Antley-Bixler syndrome; Area; Aryl Hydrocarbon Hydroxylases; Assay; Bioassay; Biochemistry; Biologic Assays; Biological Assay; Birth Defects; CP12; CPCJ; CPT7; CYP17; CYP17A1; CYP17A1 gene; CYP1A2; CYP1A2 gene; CYP2C; CYP2C19; CYP2C19 gene; Catalysis; Cells; Chemistry, Biological; Clinical; Clinical Research; Clinical Study; Coenzyme II; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; DNA Sequence; Dehydrogenases; Disease; Disorder; Dose; Drug usage; Drugs; Electrons; Endoplasmic Reticulum; Environmental Pollutants; Enzymatic Biochemistry; Enzymes; Enzymology; Ergastoplasm; Ethnic group; Exons; FAD; FMN; Female infertility; Ferricytochrome c; Ferrocytochrome c; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Flavoproteins; Gene variant; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Polymorphism; Genetic Variation; Genetic defect; Gonadal Steroid Hormones; Grant; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human Figure; Human body; Human, General; In Vitro; Individual; Laboratories; Liver Cells; Location; Man (Taxonomy); Man, Modern; Mediating; Medical; Medication; Microsomal Monooxygenases; Molecular Genetic Abnormality; Multisynostotic osteodysgenesis; Mutation; Mutation Spectra; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; Negative Beta Particle; Negatrons; Nicotinamide-Adenine Dinucleotide Phosphate; Oxidoreductase; Oxidoreductase Gene; P3-450; P450; P450(PA); P450C17; P450C2C; P450IIC19; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenetics; Pharmacogenomics; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Population; Position; Positioning Attribute; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Structure, Primary; Proteins; Receptor Protein; Reductases; Research Design; Riboflavin 5'-(dihydrogen phosphate); Riboflavin 5'-(trihydrogen diphosphate), P'-5'-ester with adenosine; Riboflavin 5'-Monophosphate; Riboflavin 5'-Phosphate; Riboflavin Mononucleotide; Role; S17AH; Sex Hormones; Sex Steroid Hormones; Study Type; Toxin; Trapezoidcephaly-multiple synostosis; Triphosphopyridine Nucleotide; Variant; Variation; Variation (Genetics); Xenobiotics; allelic variant; aminoacid; aryl 4 monooxygenase; base; cohort; cytochrome c; disease/disorder; drug metabolism; drug use; drug/agent; flavoprotein linked monooxygenase; gene product; genetic promoter element; genetic variant; genome mutation; gonadal steroids; in vitro Assay; in vivo; microsomal p450; mutant; polymorphism; protein sequence; public health relevance; receptor; response; sex steroid; social role; steroid hormone biosynthesis; study design; suprarenal gland; unspecific monooxygenase",Pharmacogenomics of Human P450 Oxidoreductase," PROJECT NARRATIVE  There is substantial variation in how people of different ethnic backgrounds metabolize drugs; understanding such variations is crucial for optimizing drug dosing in clinical settings. Much of the variation between groups is based on variations in genes encoding drug transporters and drug-metabolizing enzymes. This project explores a third possibility, a gene called POR, that is needed for the activity of drug-metabolizing enzymes.",73020,XNDA,Xenobiotic and Nutrient Disposition and Action Study Section,,6,344149,
7743834,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM073164-06,,NIGMS:357192;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,BIOCHEMISTRY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MONTELL, DENISE J.;",1873168;,5R01GM073164,02/01/2005,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Actins; Address; Affect; Animals; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Avastin; B blood cells; B-Cells; B-Lymphocytes; Biochemical; Biochemistry; Breast; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Drug; Cell Communication and Signaling; Cell Count; Cell Locomotion; Cell Migration; Cell Movement; Cell Number; Cell Polarity; Cell Signaling; Cells; Cellular Matrix; Cellular Migration; Chemistry, Biological; Chemotherapeutic Agents, Neoplastic Disease; Cytoskeletal System; Cytoskeleton; Development; Disease; Disorder; Drosophila; Drosophila genus; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EGFR; ERBB Protein; ERBB1; Embryo Development; Embryogenesis; Embryonic Development; Endosomes; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epithelial Cells; Erbitux; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; F-Actin; Filamentous Actin; Flies; Fruit Fly, Drosophila; Funding; GeneHomolog; Genes; Genetic; Genital System, Female, Ovary; HER1; Healed; Health; Homolog; Homologous Gene; Homologue; Human; Human, General; Image; In Vitro; Intracellular Communication and Signaling; Laboratories; Lead; Learning; Life; Malignant Cell; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Modeling; Molecular; Morphology; Motility; Motility, Cellular; Movement; Names; Neoplasm Metastasis; Ovary; Pathway interactions; Pattern; Pb element; Phenotype; Process; Property; Property, LOINC Axis 2; Proteins; RNA, Small Interfering; Rebif; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptosomes; Research; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Study models; TAM; Tamoxifen; Testing; Time; Transforming Growth Factor alpha Receptor; Tumor Cell; Tumor Cell Migration; Tumor-Specific Treatment Agents; VESCL; Vesicle; Wound Healing; Wound Repair; anticancer agent; anticancer drug; avonex; biological signal transduction; body movement; c-erbB-1; c-erbB-1 Protein; cancer cell; cancer metastasis; cell motility; cellular polarity; cofilin; disease/disorder; driving force; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; fly; fruit fly; gene function; gene product; healing; heavy metal Pb; heavy metal lead; imaging; in vivo; insight; intracellular skeleton; migration; mutant; neoplastic cell; pathway; protein function; proto-oncogene protein c-erbB-1; public health relevance; siRNA; tissue repair; trafficking; tumor",Cytoskeleton Dynamics in Developmental Cell Migration," The ability to move is a property of cells from virtually all animals, from simple ones such as flies and worms, all the way to humans. The proposed research focuses on the movement of a small group of cells in the fruitfly, to learn more about how specific molecules orchestrate when, where and how they move. Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells.",73164,DEV1,Development - 1 Study Section,,6,357192,
7760100,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM073188-04,,NIGMS:468723;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATHENS,UNITED STATES,CHEMISTRY,06,041077983,US,OH,457012979,OHIO UNIVERSITY ATHENS,"HINES, JENNIFER V;",1928906;,5R01GM073188,02/01/2007,01/31/2011,"Affinity; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases; Amino Acyl-tRNA Synthetases; Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Synthetase; Anti-Bacterial Agents; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Assay; Bacterial RNA; Be element; Be++ element; Beryllium; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Boxing; Cellular Expansion; Cellular Growth; Complex; Elements; Fluorescence; Gene Products, RNA; Gene Transcription; Generations; Genes; Genetic Transcription; Goals; Gram-Positive Bacteria; Hand; In Vitro; Infectious Diseases / Treatment, General; Lead; Libraries; Ligands; Methods; Methods and Techniques; Methods, Other; Miscellaneous Antibiotic; Modeling; Models, Molecular; Molecular Interaction; Molecular Models; Nucleic Acid Biochemistry, Molecular Modeling; Oxazolidinones; Pb element; Probability; Production; Protein/Amino Acid Biochemistry, Molecular Modeling; Public Health; QSAR; Quantitative Structure-Activity Relationship; RNA; RNA Expression; RNA, Bacterial; RNA, Non-Polyadenylated; Regulatory Element; RegulatoryElement; Resistance development; Resistance to antibiotics; Resistance, Antibiotic; Resistant development; Resistant to antibiotics; Ribonucleic Acid; Ribonucleic acids, transfer; Risk; Screening procedure; Series; Solutions; Structure; Structure Activity Relationship, Quantitiative; Structure-Activity Relationship; System; System, LOINC Axis 4; Techniques; Testing; Transcription; Transcription, Genetic; Transfer RNA; Transfer RNA Synthetase; Treatment of Infectious Diseases; Triplet Codon-Amino Acid Adaptor; aminoacid tRNA ligase; anti-bacterial; anti-microbial agent; anti-microbial drug; antibacterial; antibiotic resistant; antimicrobial agent; antimicrobial drug; antitermination; base; cell growth; chemical structure function; design; designing; developing resistance; drug discovery; heavy metal Pb; heavy metal lead; in vivo; infectious disease treatment; member; molecular modeling; novel; public health medicine (field); screening; screenings; structure function relationship; tRNA; tRNA Synthetase",Targeting a novel regulatory RNA with novel antibiotics,,73188,ZRG1,Special Emphasis Panel,,4,468723,
7753869,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM073874-05,,NIGMS:249166;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DAVIS,UNITED STATES,GENETICS,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"STARR, DANIEL A;",1905322;,5R01GM073874,01/01/2006,12/31/2010,"Actin Filaments; Alleles; Allelomorphs; Animals; Antigenic Determinants; Assay; Au element; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biochemical; Biologic Assays; Biological Assay; C elegans; C.elegans; Caenorhabditis elegans; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cellular Matrix; Cellular Migration; Cloning; Cytoplasm; Cytoskeletal System; Cytoskeleton; Defect; Development; Disease; Disorder; Electron Microscopy; Endoplasmic Reticulum; Engineering; Engineerings; Enhancers; Envelope Protein; Epitopes; Ergastoplasm; Esteroproteases; Eukaryota; Eukaryote; Event; Gene Products, env; GeneHomolog; Genetic; Genetic Techniques; Goals; Gold; Homolog; Homologous Gene; Homologue; Human; Human Development; Human, General; Immigrations; Immune; In Vitro; In-Migration; Label; Lead; Link; Location; Man (Taxonomy); Man, Modern; Membrane; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Micro-tubule; Microfilaments; Microtubules; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Motility; Motility, Cellular; Muscle; Muscle Tissue; Muscular Dystrophies; Myodystrophica; Myodystrophy; Myofilaments; Myoneural Junction; N-terminal; NH2-terminal; Neoplasm Metastasis; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Neuromuscular Junction; Normal Cell; Nuclear; Nuclear Envelope; Nuclear Inner Membrane; Nuclear Matrix; Nuclear Membrane; Nuclear Outer Membrane; Nuclear Scaffold; Nucleus; Organelles; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Play; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Recruitment Activity; Role; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Site; System; System, LOINC Axis 4; Technics, Genetic; Temperature; Testing; The Sun; Tumor Cell Migration; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Work; cancer metastasis; cell motility; cell type; disease/disorder; env Antigens; env Gene Products; env Polyproteins; env Protein; eukaryotida; experiment; experimental research; experimental study; gene product; genome-wide; heavy metal Pb; heavy metal lead; in vivo; insight; intracellular skeleton; lissencephaly; membrane structure; migration; nervous system disorder; neurological disease; novel; null mutation; pathway; polarized cell; protein function; recruit; research study; social role",Mechanisms of Nuclear Migration and Anchorage,,73874,CSF,Cell Structure and Function Study Section,,5,249166,
7760860,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM073937-03,,NIGMS:396339;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,ENGINEERING (ALL TYPES),07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MAO, HAI-QUAN ;",7668976;,5R01GM073937,04/01/2008,01/31/2012,"Bile Tract; Biliary System; Biliary Tract; Biliary Tree; Biliary tract structure; Binding; Binding (Molecular Function); Biocompatible; Biocompatible Materials; Biological; Biomaterials; Blood; Blood Circulation; Bloodstream; Body Tissues; Buffers; Cancers; Cells; Cellular biology; Characteristics; Circulation; Clinical Sciences; Common Rat Strains; Complex; D-Galactose; DNA; DNA Binding; DNA Binding Interaction; Deoxyribonucleic Acid; Discontinuous Capillary; Disease; Disease by Site; Disorder; Disorder by Site; Disulfides; Drug Formulations; Encapsulated; Exhibits; Factor VIII Deficiency; Formulation; Formulations, Drug; Foundations; Future; Galactopyranose; Galactopyranoside; Galactose; Gene Delivery; Gene Expression; Gene Targeting; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Condition; Genetic Diseases; Genetic Intervention; Hemophilia; Hemophilia A; Hemophilia As; Hepatic Cancer; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; Hereditary; Hereditary Disease; Histocompatibility; IFN; Imidazole; Immunologic, Luciferase; In Vitro; Infusion; Infusion procedures; Inherited; Interferons; Intervention, Genetic; Intracellular Transport; Intravenous; Kinetic; Kinetics; Kupffer Cells; Length; Libraries; Liver; Liver Cells; Liver diseases; Luciferases; Lytotoxicity; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Rats; Mediating; Medicine; Metabolic; Methods; Micelles; Molecular; Molecular Biology, Gene Therapy; Molecular Disease; Molecular Interaction; Physiologic; Physiological; Polymer Chemistry; Polymers; Property; Property, LOINC Axis 2; Rat; Rattus; Research; Reticuloendothelial System, Blood; Science of Medicine; Series; Sinusoid; Sinusoidal Capillary; Site; Stellate Sinusoidal Macrophage; Structure; Surface; System; System, LOINC Axis 4; Systemic disease; Targetings, Gene; Therapeutic; Therapy, DNA; Tissue Compatibility; Tissues; Toxic effect; Toxicities; Transfection; Transgenes; Viral Diseases; Viral hepatitis; Virus Diseases; biliary tract; biocompatibility; biomaterial compatibility; body system, hepatic; cell biology; cholangiocyte; clinical applicability; clinical application; copolymer; cross-link; crosslink; cytotoxicity; design; designing; disease/disorder; extracellular; gene therapy; genetic disorder; genetic therapy; hepatopathy; hereditary disorder; improved; in vivo; innovate; innovation; innovative; intravenous injection; liver cancer; liver disorder; liver macrophage; malignancy; malignant liver tumor; meetings; neoplasm/cancer; novel; organ system, hepatic; polycation; protein expression; secretory protein; site targeted delivery; targeted delivery; trafficking; transfer of a gene; transgene expression; uptake; viral infection; viral nanoparticle; virus infection",Biodegradable Micelles for Liver-Targeted Gene Delivery,,73937,BMBI,Biomaterials and Biointerfaces Study Section,,3,396339,
7753163,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM073969-04,,NIGMS:261031;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,050299031,US,TX,770051892,RICE UNIVERSITY,"NIKONOWICZ, EDWARD P;",1925576;,5R01GM073969,01/15/2007,12/31/2010,"Adopted; Amino Acids; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases; Amino Acyl-tRNA Synthetases; Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Synthetase; Anticodon; Arm; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Boxing; Calorimetry; Charge; Chemicals; Codon; Codon Nucleotides; Collaborations; Combining Site; Complex; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; EC 2.7.7.6; Elements; Environment; Exhibits; Gene Expression; Gene Products, RNA; Gene Transcription; Genes; Genetic Transcription; Goals; Gram-Positive Bacteria; Heteronuclear NMR; Heteronuclear Nuclear Magnetic Resonance; In Vitro; Individual; Intermediary Metabolism; Investigators; Knowledge; Letters; Ligands; METBL; Measures; Mediating; Messenger RNA; Metabolic Processes; Metabolism; Modification; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; NMR Spectroscopy; NMR, Heteronuclear; Nature; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleotides; Ohio; Peptide Biosynthesis, Ribosomal; Physiologic; Physiological; Physiology; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; RNA; RNA Expression; RNA Polymerases; RNA, Messenger; RNA, Non-Polyadenylated; Reactive Site; Reading; Research Design; Research Personnel; Researchers; Ribonucleic Acid; Ribonucleic acids, transfer; Ribosomes; Role; Schools, Medical; Solutions; Specific qualifier value; Specified; Spectroscopy, NMR; Structure; Study Type; System; System, LOINC Axis 4; Testing; Thermodynamic; Thermodynamics; Titrations; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transfer RNA; Transfer RNA Synthetase; Translations; Triplet Codon-Amino Acid Adaptor; Triplet Multiple Birth; Triplets; Universities; Upper arm; Work; aminoacid; aminoacid tRNA ligase; anti-microbial; antimicrobial; antitermination; base; chemical property; conformation; conformational state; experiment; experimental research; experimental study; in vivo; mRNA; medical schools; mutant; nuclear magnetic resonance spectroscopy; pathogen; prevent; preventing; programs; protein synthesis; research study; sensor; social role; stem; study design; tRNA; tRNA Synthetase; transcription termination",Modified Bases in tRNA-Mediated Antitermination,,73969,MSFB,Macromolecular Structure and Function B Study Section,,4,261031,
7765577,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM074070-05,,NIGMS:226499;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATLANTA,UNITED STATES,CHEMISTRY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"GALLIVAN, JUSTIN P;",6440900;,5R01GM074070,02/01/2006,01/31/2011,"1,3,7-Trimethylxanthine; 1,3-Dimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione; Abbreviations; Address; Affinity; Alkaloids; Anabolism; Aryl Hydrocarbon Hydroxylase; Assay; Bacteria; Behavior; Beverages; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Factors; CYP 1A2; Caffeine; Caffeine Demethylase; Catabolism; Cells; Characteristics; Chemicals; Cloning; Codeine; Coffea arabica; Coffea arabica (Plant); Coffee; Combining Site; Constant T; ConstantT; Contin, MS; Coptis; Cytochrome P-450 CYP1A2; Cytochrome P-450 LM(4); Cytochrome P-450 LM4; Cytochrome P-450, Aromatic Compound-Inducible; Cytochrome P-450d; Cytochrome P450 1A2; Cytochrome P450, Family 1, Subfamily A, Polypeptide 2; Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2; Detection; Development; Dioxin-Inducible P3-450; E coli; Elixophyllin; Engineering; Engineerings; Enzymes; Escherichia coli; Evolution; Factor, Biologic; Future; Gene Expression; Gene Products, RNA; Gene-Modified; Genes; Genetic; Genetic Screening; Goals; Goldthread; In Vitro; Infumorph; Investigators; Kadian; LaBID; Libraries; Life; MSir; Mediating; Medicine; Messenger RNA; Metabolic; Metabolic Pathway; Methods; Methylation; Molecular Interaction; Monitor; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-; Morphine; N-Methylmorphine; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Oramorph; Oramorph SR; P(3)450; P450 4; P450 Form 4; P450 orm 4; P450-P3; Pathway interactions; Phenacetin O-Dealkylase; Plants; Plants, General; Problem Solving; Production; Programs (PT); Programs [Publication Type]; Protein Methylation; Proteins; RNA; RNA Sequences; RNA, Messenger; RNA, Non-Polyadenylated; Reactive Site; Research Personnel; Researchers; Respbid; Rest; Ribonucleic Acid; Ribosomes; Roxanol; Science of Medicine; Selection (Genetics); Sensitivity and Specificity; Sequences, RNA; Slo Phyllin; Slo-bid; SloPhyllin; Solutions; Somophyllin T; Somophyllin-CRT; SomophyllinT; Statex SR; Structure; T-Phyl; Tea; Theo 24; Theo24; Theobid Duracap; Theochron; Theophylline; Translations; UTRs; Uniphyl; United States National Institutes of Health; Untranslated Regions; aptamer; base; biosynthesis; cDNA Library; demethylation; design; designing; dimethyl sulfate; dimethylsulfate; directed evolution; enzyme activity; experiment; experimental research; experimental study; gene product; improved; in vivo; insight; mRNA; methyl group; pathway; programs; reconstitute; reconstitution; research study; response; small molecule; tool",RNA-Mediated Genetic Selections for Small Molecules,,74070,SBCA,Synthetic and Biological Chemistry A Study Section,,5,226499,
7753856,R01,GM,5,,01/01/2010,12/31/2010,PAR-03-106,5R01GM074163-05,,NIGMS:188696;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,BIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"ZHOU, XIANGHONG JASMINE;",8051649;,5R01GM074163,01/01/2006,12/31/2010,"Address; Aging; Algorithms; Binding Sites; Biochemical; Biological; C elegans; C.elegans; Caenorhabditis elegans; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Collection; Combining Site; Common Rat Strains; Communities; Computer Programs; Computer software; DNA Binding; DNA Binding Interaction; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Disease; Disorder; Flies; Fungal Genome; Gene Action Regulation; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic; Genetic Structures; Genetic Transcription; Genome; Genome, Fungal; Goals; Graph; Graphical interface; Human; Human, General; Individual; Internet; Investigators; Jasmine; Jasminum; Knowledge; Laboratories; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Method LOINC Axis 6; Methodology; Methods; Mice; Microarray Analysis; Microarray-Based Analysis; Murine; Mus; Organism; Pathway interactions; Pattern; Phenotype; Plants; Plants, General; Position; Positioning Attribute; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; RNA Expression; Rat; Rattus; Reactive Site; Recurrence; Recurrent; Research Personnel; Researchers; S cerevisiae; Saccharomyces cerevisiae; Senescence; Software; Solutions; Statistical Methods; Subcellular Process; Technology; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription, Genetic; Translating; Translatings; Variant; Variation; WWW; Yeast, Baker's; Yeast, Brewer's; Yeasts; base; clinical data repository; clinical data warehouse; computer program/software; data repository; design; designing; develop software; developing computer software; disease/disorder; experiment; experimental research; experimental study; fly; gene function; gene interaction; gene product; graphic user interface; graphical user interface; improved; language translation; living system; microarray technology; new approaches; novel; novel approaches; novel strategies; novel strategy; pathway; programs; relational database; repository; research study; senescent; software development; web; world wide web; yeast genome",Integrative Analysis of Cross-Platform Microarray Data,,74163,BDMA,Biodata Management and Analysis Study Section,,5,188696,
7755850,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM074212-04,,NIGMS:248243;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATHENS,UNITED STATES,BIOLOGY,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"KIPREOS, EDWARD T.;",1936999;,5R01GM074212,02/01/2007,01/31/2011,"1-Ethyl-1-nitrosourea; APF-1; ATP-Dependent Proteolysis Factor 1; Affinity Chromatography; Alleles; Allelomorphs; Anaphase; Animals; Binding; Binding (Molecular Function); Bypass; C elegans; C.elegans; CNS Neoplasms, Malignant; CTNNB1; CUL-2; CUL2; CUL2 gene; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Caenorhabditis elegans; Cancer Biology; Cancer of the CNS; Cancers; Catenin, Beta-1; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Central Nervous System Cancer; Chromatography, Affinity; Chromosome Condensation; Complex; Coupled; Cyclin B; Cyclins; Defect; Development; ENU; Ethylnitrosourea; Event; Foundations; Genes; Genetic; Genetic Screening; Genetic analyses; Genotoxins; Goals; HMG-20; High Mobility Protein 20; Human; Human, General; In Vitro; Individual; Kidney; Link; M Phase; M phase (cell cycle); Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the CNS; Malignant Tumor of the Central Nervous System; Malignant neoplasm of central nervous system; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mediating; Meiosis; Metaphase; Mitosis; Mitosis Stage; Mitotic; Mitotic Anaphase; Mitotic Metaphase; Molecular; Molecular Interaction; Mutagens; N-Ethyl-N-nitrosourea; Nitrosoethylurea; P62 (cyclin B); PRO2286; Pathway interactions; Pattern; Phase Transition; Phenotype; Photometry/Spectrum Analysis, Mass; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Analysis; Protein Cleavage; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Subunits; Protein Turnover; Proteins; Proteolysis; Protocol; Protocols documentation; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Research; Role; Sequence-Specific Posttranscriptional Gene Silencing; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; Temperature; Tumor Suppressor Proteins; Two Hybrid; Ubiquitilation; Ubiquitin; Ubiquitin-mediated Proteolysis; Ubiquitin-mediated Proteolysis Pathway; Ubiquitination; Ubiquitinoylation; Urea, N-ethyl-N-nitroso-; Urinary System, Kidney; VHL Tumor Suppressor Protein; Von Hippel-Lindau Tumor Suppressor Protein; Yeast One Hybrid System; Yeast One/Two-Hybrid System; affinity purification; anti-cancer therapeutic; anticancer therapeutic; base; beta catenin; cancer progression; cdc13 Protein; experiment; experimental research; experimental study; gene product; genetic analysis; genotoxic agent; in vivo; insight; loss of function; malignancy; meiotic; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; novel; overexpression; p56cdc13; pathway; prevent; preventing; protein degradation; protein function; renal; research study; sex determination; social role; tumor; tumor progression; tumor suppressor; ubiquination; ubiquitin conjugation; ubiquitin ligase; yeast two hybrid system",Cell cycle regulation by C. elegans CUL-2 E3 complexes,,74212,MGA,Molecular Genetics A Study Section,,4,248243,
7750550,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM074619-04,,NIGMS:275275;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"WEISBLAT, DAVID A;",1883568;,5R01GM074619,01/01/2007,12/31/2010,"Activin-beta Subunits; Acute; Ally; Amino Acid Sequence; Animal Model; Animal Models and Related Studies; Animals; Annelida; Arthropoda; Arthropods; Articulation; Birth Defects; Bone-Derived Transforming Growth Factor; Brachyury; Brachyury protein; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cleaved cell; Comparative Study; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Consensus; Development; Developmental Process; Dorsal; Drosophila; Drosophila genus; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Evolution; Family; Flatworms; Fruit Fly, Drosophila; Gene Expression; GeneHomolog; Genes; Genetic Models; Genetics, in situ Hybridization; Genome; Genomics; Goals; Hirudinea; History; Homolog; Homologous Gene; Homologue; Human; Human, General; In Situ Hybridization; Inhibin-beta Subunits; Injection of therapeutic agent; Injections; Institutes; Intracellular Communication and Signaling; Investigation; Joints; Juglans; Laboratories; Leeches; Life; Ligands; Light; Link; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Milk Growth Factor; Models, Genetic; Molecular; Molecular Biology, Protein Sequencing; Molecular Genetic Abnormality; Morphology; Natural regeneration; Nematoda; Nematodes; Neoplasm Metastasis; Organism; Pathway interactions; Pattern; Peptide Sequence Determination; Photoradiation; Phylogenetic Analysis; Phylogenetics; Phylogeny; Platelet Transforming Growth Factor; Platyhelminthes; Platyhelminths; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Sequencing; Protein Structure, Primary; RT-PCR; RTPCR; Recording of previous events; Recruitment Activity; Regeneration; Regulation; Research; Reverse Transcriptase Polymerase Chain Reaction; Role; Sampling; Secondary Neoplasm; Secondary Tumor; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Staging; Study models; Subcellular Process; System; System, LOINC Axis 4; T Brachyury protein; TGF B; TGF-beta; TGFbeta; Tag; Taxon; Tracer; Transforming Growth Factor beta; Trees; Tumor Cell Migration; Vertebrate Animals; Vertebrates; Walnut; Work; Worms, Segmented; base; beta-Activin; beta-Activin Polypeptide; beta-Inhibin; beta-Inhibin Polypeptide; biological signal transduction; cancer metastasis; cell behavior; chordin; cleaved; comparative; epithelial to mesenchymal transition; experiment; experimental research; experimental study; falls; fruit fly; genome sequencing; in situ Hybridization Staining Method; insight; living system; model organism; pathway; precursor cell; programs; protein sequence; recruit; regenerate; research study; reverse transcriptase PCR; roundworm; social role; stem cell biology; vertebrata","TGF-beta and axis formation in Helobdella, a lophotrochozoan",,74619,GVE,Genetic Variation and Evolution Study Section,,4,275275,
7754666,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM074748-04,,NIGMS:313706;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DUARTE,UNITED STATES,,32,027176833,US,CA,910103000,CITY OF HOPE/BECKMAN RESEARCH INSTITUTE,"CHEN, YUAN ;",1895954;,5R01GM074748,01/01/2007,12/31/2010,"APF-1; ATP-Dependent Proteolysis Factor 1; Accounting; Active Sites; Amino Acid Sequence; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Body Tissues; C-terminal; Cancers; Catalysis; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Chemistry; Combining Site; Complex; Conserved Sequence; DNA Damage Repair; DNA Repair; E3 Ligase; E3 Ubiquitin Ligase; Enzymatic Biochemistry; Enzyme Kinetics; Enzymes; Enzymology; Gene Transcription; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; HMG-20; High Mobility Protein 20; Investigators; Knowledge; Malignant Neoplasms; Malignant Tumor; Mediating; Model System; Models, Biologic; Modification; Molecular Interaction; Mutation; NMR Spectroscopy; Names; Nature; Nobel Prize; Pathway interactions; Phosphorylation; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Structure, Primary; Protein translocation; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; RNA Expression; Reaction; Reactive Site; Recruitment Activity; Regulation; Research Personnel; Researchers; Role; Science of Chemistry; Scientist; Site; Sites, Active; Specificity; Spectroscopy, NMR; Structure; Study Section; Tissues; Transcription; Transcription, Genetic; Transmembrane Protein Transport; Ubiquitilation; Ubiquitin; Ubiquitin Like Proteins; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Unscheduled DNA Synthesis; Variant; Variation; chemical reaction; enzyme mechanism; gene product; genome mutation; improved; malignancy; neoplasm/cancer; novel; nuclear magnetic resonance spectroscopy; pathway; programs; protein complex; protein sequence; recruit; social role; therapeutic target; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",The Enzymatic Pathway of a Ubiquitin-Like Modification,,74748,MSFC,Macromolecular Structure and Function C Study Section,,4,313706,
7761187,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM074771-04,,NIGMS:338598;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,ANESTHESIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"DELPIRE, ERIC J;",1861968;,5R01GM074771,02/01/2007,01/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Affect; Afferent Neurons; Aminalon; Aminalone; Antimorphic mutation; Assay; BSC1 protein; BSC1 transport protein; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Pressure, High; Body Tissues; Brain; Butanoic acid, 4-amino-; Cations; Cell Line; Cell Lines, Strains; Cell Proliferation Regulation; Cell Volumes; Cell membrane; Cell surface; CellLine; Cells; Cellular Expansion; Cellular Growth; Chemotherapy-Hormones/Steroids; Chloride; Chloride Ion; Chlorides; Cl- element; Co-Immunoprecipitations; Cytoplasmic Membrane; Dephosphorylation; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsal Root Ganglia; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Ear, Internal; Encephalon; Encephalons; Endocrine Gland Secretion; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelium; Family; GABA; Ganglia, Spinal; Goals; HEK3; Hearing Loss, Sensorineural; Hormones; Human; Human, General; Hybrids; Hypertension; Immune Precipitation; Immunoprecipitation; In Vitro; Investigators; Ions; Kinases; Knock-out; Knockout; Laboratories; Labyrinth; Lead; Link; Liquid substance; Man (Taxonomy); Man, Modern; Maps; Measurement; Mediating; Membrane; Molecular Interaction; Movement; Mutagenesis, Site-Directed; NKCC2 cotransporter; NKCC2 gene product; NRVS-SYS; Na/K/2CI cotransporter; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Transmission; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuron Degeneration; Neuronal Differentiation; Neurons; Neurons, Afferent; Neurons, Sensory; Nociception; Oocytes; Organ; Ovocytes; PTK; Pain; Painful; Pb element; Phenotype; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Plasma Membrane; Platanna; Play; Production; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein phosphatase; Proteins; Recruitment Activity; Regulation; Regulatory Protein; Research Personnel; Researchers; Role; SLC12A1 cotransporter; Scaffolding Protein; Sensorineural Deafness; Sensorineural Hearing Loss; Sensory Cell Afferent Neuron; Sensory Hearing Loss; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium Chloride; Sodium chloride (NaCl); Spinal Ganglia; Stimulus; Stress; Synaptic Transmission; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Therapeutic Hormone; Tissues; Transfection; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Volumes, Cell; Work; Xenopus laevis; Yeasts; base; body movement; cell growth; cultured cell line; cytokine; disease/disorder; dorsal root ganglion; experiment; experimental research; experimental study; fluid; gamma-Aminobutyric Acid; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; hydroxyaryl protein kinase; hyperpiesia; hyperpiesis; hypertensive disease; inner ear; liquid; membrane structure; mutant; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; nociceptive; novel; overexpression; phosphatase inhibitor; plasmalemma; programs; recruit; regulatory gene product; research study; response; salt; social role; sodium-potassium chloride cotransporter 2 protein; solute-carrier family 12 (sodium/potassium/chloride transporters), member 1; trafficking; tyrosyl protein kinase; wasting",KINASES IN ION COTRANSPORTER FUNCTION,,74771,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,4,338598,
7759530,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM075060-04,,NIGMS:255738;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLOOMINGTON,UNITED STATES,BIOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"MICHAELS, SCOTT ;",7931631;,5R01GM075060,02/01/2007,01/31/2012,"Affect; Alleles; Allelomorphs; Apical; Arabidopsis; Behavior; Biochemical; Biological; Biology; Blooms, Plant; Blossoms; Cell Communication and Signaling; Cell Signaling; Cells; Chromatin Structure; Complex; Coupled; Data; Development; Endogenous Factors; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Flowers; Gene Expression; Gene Products, RNA; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic analyses; Genetic defect; Goals; HDAC; HDAC Proteins; Histone Deacetylase; Homeo Domain; Human; Human, General; Individual; Interest Group; Intracellular Communication and Signaling; Knowledge; Laboratories; Left; Libraries; Life Cycle; Life Cycle Stages; Link; Man (Taxonomy); Man, Modern; Mediating; Meristem; Messenger RNA; Molecular; Molecular Analysis; Molecular Genetic; Molecular Genetics; Mother Cells; Mutation; Organ; Pathway interactions; Phenotype; Plants; Plants, General; Play; Polyadenylation Factor; Pre-mRNA Polyadenylation Factor; Primordium; Progenitor Cells; Proteins; RNA; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA, Messenger; RNA, Non-Polyadenylated; RNA-Binding Proteins; Regulation; Repression; Research; Ribonucleic Acid; Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; Structure; Testing; Time; Two Hybrid; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; biological signal transduction; chromatin modification; design; designing; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; histone modification; homeodomain; insight; life course; loss of function mutation; mRNA; mutant; null mutation; overexpression; pathway; protein protein interaction; reproductive; reproductive success; research study; screening; screenings; social role; transcription factor; yeast two hybrid system",Molecular analysis of the autonomous pathway,,75060,DEV1,Development - 1 Study Section,,4,255738,
7747924,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM076092-05,,NIGMS:261258;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLLEGE STATION,UNITED STATES,BIOLOGY,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"MAGGERT, KEITH A;",1884898;,5R01GM076092,01/01/2006,12/31/2010,"2(1H)-Pyrimidinone, 4-amino-; Address; Adopted; Affect; Area; Assay; Bears; Behavior; Behavioral Genetics; Bioassay; Biologic Assays; Biological Assay; Birth Defects; Body Tissues; Cancers; Cell Growth and Maintenance; Cell Maintenance; Cell division; Cells; Chromatin; Chromatin Structure; Chromosomes; Cognitive Discrimination; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cytosine; DNA; DNA Methylation; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA Sequence; DNA-Methyltransferases; Data; Deoxyribonucleic Acid; Development; Discrimination; Discrimination (Psychology); Disease; Disorder; Dnmt; Drosophila; Drosophila genus; EC 2.1.1.113; Embryo; Embryonic; Exhibits; Female; Fruit Fly, Drosophila; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Determinants of Behavior; Genetic Diseases; Genetic Imprinting; Genetic analyses; Genetic defect; Genetics, Behavioral; Genetics, in situ Hybridization; Genome; Genomic Imprinting; Genotype; Goals; Gonosomes; Hereditary; Hereditary Disease; Human; Human, General; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; In Situ Hybridization; Individual; Inherited; Investigation; Investigators; Life; Link; Location; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Maps; Mediating; Memory; Methods and Techniques; Methods, Other; Methylation; Mitotic; Modeling; Modification Methylases; Molecular; Molecular Biology, Recombinant DNA; Molecular Disease; Molecular Genetic Abnormality; Monitor; Mother Cells; Mutate; Mutation; Nature; Organism; Parental Imprinting; Parents; Phenotype; Plants; Plants, General; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Methylation; Proteins; RNA; RNA, Non-Polyadenylated; Reagent; Recombinant DNA; Regulation; Reporter Genes; Research; Research Personnel; Researchers; Ribonucleic Acid; Role; Sex Chromosomes; Site-Specific DNA-methyltransferase; Somatic Cell; Specificity; Sperm; Spermatozoa; Stem cells; Targetings, Gene; Techniques; Testing; Time; Tissues; Transgenes; Ursidae; Ursidae Family; Work; X Chromosome; Y Chromosome; autosome; base; behavior genetics; bisulfite; chromosome loss; disease/disorder; fruit fly; gene product; genetic analysis; genetic disorder; genome mutation; hereditary disorder; homologous recombination; hydrogen sulfite; hydrosulfite; imprint; in situ Hybridization Staining Method; living system; male; malignancy; maternal imprint; mutant; neoplasm/cancer; next generation; novel; offspring; paternal imprint; positional cloning; programs; rDNA; reverse genetics; sex; sex-specific imprints; social role; sperm cell; study characteristics; zoosperm",DNA Methylation in Drosophila,,76092,MGB,Molecular Genetics B Study Section,,5,261258,
7755847,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM076237-05,,NIGMS:233161;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"LUO, XU ;",8243808;,5R01GM076237,02/01/2006,01/31/2011,"Amino Acids; Apoptosis; Apoptosis Pathway; Apoptosis Regulator; Apoptotic; Assay; Autoregulation; BAX; BAX Isoform Alpha; BCL2-Associated X Protein; BH3 Domain; Bax protein; Bioassay; Biochemical; Biochemical Pathway; Biochemistry; Biologic Assays; Biological Assay; Blood (Leukemia); Body Tissues; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chemistry, Biological; Cytoplasm; DNA Molecular Biology; Development; Dimerization; Disease; Disorder; Family member; Genetic; Goals; Homeostasis; Homo; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Investigators; Knowledge; Lead; Leukemias, General; Location; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic Networks; Methods and Techniques; Methods, Other; Mitochondria; Molecular; Molecular Biology; Monitor; Organism; Outer Mitochondrial Membrane; Pathway interactions; Pb element; Physiological Homeostasis; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Programs (PT); Programs [Publication Type]; Protein Dimerization; Protein Family; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Regulation; Research; Research Personnel; Research Proposals; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; System; System, LOINC Axis 4; Techniques; Technology; Therapeutic; Therapeutic Agents; Tissues; Transfection; UV induced; Uncertainty; aminoacid; anticancer therapy; base; biological signal transduction; cancer therapy; design; designing; disease/disorder; doubt; feeding; gene product; heavy metal Pb; heavy metal lead; in vitro Assay; in vivo; insight; leukemia; living system; malignancy; mitochondrial; mouse model; mutant; neoplasm/cancer; pathway; prevent; preventing; programs; siRNA; social role; stem",Mechanisms of Bax Activation,,76237,CSD,Cellular Signaling and Dynamics Study Section,,5,233161,
7759207,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM076244-05,,NIGMS:245349;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MADISON,UNITED STATES,ZOOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"GRINBLAT, YEVGENYA ;",1901464;,5R01GM076244,02/01/2006,01/31/2011,"Address; Affect; Animal Model; Animal Models and Related Studies; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Models; Birth Defects; Brachydanio rerio; Brain; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Proliferation; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Danio rerio; Data; Defect; Development; Dorsal; Embryo; Embryo Development; Embryogenesis; Embryology; Embryology / Fetal Growth; Embryonic; Embryonic Development; Encephalon; Encephalons; Ensure; Evolution; Exencephalies; Exencephaly; Family; Feedback; Fore-Brain; Forebrain; GFAC; Gene Family; Gene Transcription; GeneHomolog; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genome; Genomics; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Holoprosencephaly; Homolog; Homologous Gene; Homologue; Human; Human Development; Human, General; Intracellular Communication and Signaling; Link; Man (Taxonomy); Man, Modern; Mesencephalon; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mid-brain; Midbrain; Midbrain structure; Model System; Models, Biologic; Molecular; Molecular Genetic Abnormality; Mutation; Nervous System, Brain; Neural Tube Closure; Neural tube; Pattern; Play; Position; Positioning Attribute; Primordium; Process; Prosencephalon; RNA Expression; Reagent; Regulation; Research; Role; Schistorrhachis; Signal Transduction; Signal Transduction Systems; Signaling; Spina Bifida; Spinal Dysraphia; Spinal Dysraphias; Spinal Dysraphism; Spinal Dysraphisms; Staging; Techniques; Technology; Testing; Time; Transcription; Transcription, Genetic; Transgenic Organisms; Transplantation; Vertebrate Animals; Vertebrates; Work; Zebra Danio; Zebra Fish; Zebrafish; biological signal transduction; cleft spine; genome mutation; hydrocele spinalis; knock-down; member; model organism; mutant; novel; positional cloning; rachischisis posterior; reverse genetics; social role; tool; transcription factor; transgenic; transplant; vertebrata",Role for zic genes in the developing midbrain.,,76244,DEV,Development - 1 Study Section,,5,245349,
7762751,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM076275-05,,NIGMS:255769;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRINCETON,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"SINGH, MONA ;",7080878;,5R01GM076275,02/18/2006,01/31/2011,"2PP2A; ATP[{..}]protein-tyrosine O-phosphotransferase; Algorithms; Amino Acid Sequence; Amino Acids; Animal Model; Animal Models and Related Studies; Arts; Binding; Binding (Molecular Function); Bio-Informatics; Biochemical; Biochemical Pathway; Bioinformatics; Biological Function; Biological Process; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Computer Analysis; Computer Programs; Computer software; Consensus; DNA; DNA-Protein Interaction; Data; Deoxyribonucleic Acid; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Evolution; Future; Genome; Genomics; Goals; HEK3; HLA-DR Associated Protein II; Hand; Health; Human; Human, General; I2PP2A; IGAAD; Inhibitor of GZMA-Activated DNase; Internet; Intracellular Communication and Signaling; Investigators; Man (Taxonomy); Man, Modern; Maps; Mediating; Metabolic Networks; Methods; Mining; Minings; Modeling; Molecular Biology, Protein Sequencing; Molecular Interaction; Network Analysis; Organism; PHAPII; PTK; Pathway Analysis; Pathway interactions; Pattern; Peptide Sequence Determination; Phosphatase 2A Inhibitor I2PP2A; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Sequencing; Protein Structure, Primary; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Research; Research Personnel; Researchers; S cerevisiae; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; SH2-containing protein; SH3 Domains; SHC; SHC1 (Src homology 2 domain-containing) protein; SRC Homology Region 3 Domain; Saccharomyces cerevisiae; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Set protein; Shc protein; Signal Transduction; Signal Transduction Systems; Signaling; Software; Specific qualifier value; Specificity; Specified; Src homology 2 domain-containing protein; Src homology 2 domain-containing, transforming protein 1; Structure; System; System, LOINC Axis 4; TAF-IBETA; Template Activating Factor I Beta; Testing; Time; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; WWW; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; aminoacid; biological signal transduction; computational analysis; computer program/software; disease/disorder; gene product; genome sequencing; high throughput technology; human disease; hydroxyaryl protein kinase; improved; living system; model organism; novel; pathway; programs; protein function; protein sequence; tool; tyrosyl protein kinase; web; world wide web",Predicting and analyzing protein interaction networks,,76275,BDMA,Biodata Management and Analysis Study Section,,5,255769,
7752560,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM076360-05,,NIGMS:272570;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DAVIS,UNITED STATES,CHEMISTRY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHEN, XI ;",8038661;,5R01GM076360,01/01/2006,12/31/2010,"Acetylation; Acylneuraminate Cytidylyltransferase; Acylneuraminyl hydrolase; Anabolism; Animals; Antigenic Determinants; Binding; Binding (Molecular Function); Binding Determinants; Binding Proteins; Biochemical; Biological; Biological Function; Biological Process; C element; CMP Acetylneuraminic Acid; CMP Sialate Pyrophosphorylase; CMP Sialate Synthase; CMP-N-Acetylneuraminic Acid Synthetase; CMP-NANA; CMP-Sialic Acid; CMP-Sialic Acid Synthetase; CTP[{..}]N-acylneuraminate cytidylyltransferase; Cancers; Carbohydrates; Carbon; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell Surface Glycoproteins; Cell-to-Cell Interaction; Cells; Charge; Chemicals; Cytidine 5'-Monophosphosialic Acid Synthetase; Cytidine 5-Monophosphosialate Synthase; Cytidine Monophosphate N-Acetylneuraminic Acid; D-Mannose; D-glycero-beta-D-galacto-2-Nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-, 2-(hydrogen 5'-cytidylate); DSCSPG; Degradation Pathway; Degradative Pathway; Development; Disease; Disorder; E coli; Enzymes; Epitopes; Escherichia coli; Family; Glycoconjugates; Glycolipids; Glycoproteins; Glycosaminoglycans; Goals; Grant; Hemagglutinin; Heparin; Heparinic Acid; Human; Human, General; INFLM; In element; Indium; Infection; Inflammation; Inflammatory; Inorganic Sulfates; Intracellular Communication and Signaling; Investigators; Keratin; Lactams; Lactone Compound; Lactones; Lead; Libraries; Ligand Binding Protein; Ligands; Link; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mannopyranose; Mannopyranoside; Mannose; Membrane Glycoproteins; Methods; Methylation; Microorganisms, General; Modification; Molecular Interaction; Monosaccharides; Mucopolysaccharides; N-Acetylneuraminate lyase; N-Acetylneuraminic Acids; N-Acylneuraminate Cytidylyltransferase; N-Acylneuraminate Glycohydrolases; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NANA-aldolase; Nature; Neu-5-Ac lyase; NeuAc lyase; Neuraminidase; Oligosaccharide Sialidase; Oligosaccharides; Pasteurella multocida; Pathologic Processes; Pathological Processes; Pb element; Phosphorylation; Physical condensation; Physiologic; Physiological; Physiology; Pituitary Hormones; Play; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Protein Methylation; Protein Phosphorylation; Protein-Carbohydrate Interaction; Proteins; Proteoglycan; Pyruvate; Pyruvates; Reaction; Research; Research Personnel; Researchers; Role; Selectins; Sialic Acids; Sialidase; Sialyltransferases; Signal Transduction; Signal Transduction Systems; Signaling; Source; Structure; Structure-Activity Relationship; Substrate Specificity; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; Sulfatides; Sulfatoglycosphingolipids; Sulfoglycosphingolipids; Surface Glycoproteins; System; System, LOINC Axis 4; Unspecified or Sulfate Ion Sulfates; Vertebrate Animals; Vertebrates; Viral; Virus; Viruses, General; acylneuraminate pyruvate lyase; analog; analytical method; base; biological signal transduction; biosynthesis; carbohydrate structure; chemical structure function; chemical synthesis; condensation; dermatan sulfate chondroitin sulfate; disease/disorder; exo alpha sialidase; gene product; heavy metal Pb; heavy metal lead; human disease; malignancy; microorganism; molecular recognition; neoplasm/cancer; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathogenic bacteria; programs; seminolipid; sialic acid aldolase; social role; structure function relationship; sugar; sulfate; sulfation; vertebrata",Studies of naturally occurring structurally modified carbohydrates,,76360,SBCA,Synthetic and Biological Chemistry A Study Section,,5,272570,
7753643,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM076561-05,,NIGMS:243774;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"GOTTARDI, CARA J;",1933968;,5R01GM076561,01/01/2006,12/31/2010,"Adherens Junction; Adhering Junction; Adhesions; Adhesive Junction; Adhesives; Affect; Affinity; Anchoring Junction; Anti-Oncogenes; Antibodies; Antioncogenes; Assay; Automobile Driving; Back; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; C-terminal; Cadherins; Cancers; Cell Adhesion; Cell Attachment; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Adhesion; Cellular Function; Cellular Physiology; Cellular Process; Cellular Transformation; Complex; Cytoplasmic Domain; Cytoplasmic Tail; Data; Development; Dorsum; Drivings, Automobile; Emerogenes; Exhibits; Gene Targeting; Gene Transcription; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genetic Transcription; Genetics-Mutagenesis; In Vitro; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; LEF Transcription Factor; Liver Cell Adhesion Molecules; Lymphoid Enhancer Factor; Malignant Neoplasms; Malignant Tumor; Maps; Measures; Mediating; Methods and Techniques; Methods, Other; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Morphogenesis; Mutagenesis; N-terminal; NH2-terminal; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenic; PPIase; Pathway interactions; Peptidyl-Prolyl cis-trans-Isomerase; Peptidylproline cis-trans-isomerase; Peptidylprolyl Isomerase; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphopeptides; Phosphoric Monoester Hydrolases; Phosphorylation; Phylogenetic Analysis; Phylogenetics; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-Translational Modifications; Post-Translational Protein Processing; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Proline Isomerase; Proline Rotamase; Prolyl Isomerase; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Relative; Relative (related person); Reporter; Research Personnel; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Structure; Subcellular Process; T Cell Factor; TCF Transcription Factor; Targetings, Gene; Techniques; Testing; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Tumor Suppressing Genes; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Genes; Tumor Suppressor Proteins; Up-Regulation; adhesion receptor; base; biological signal transduction; cancer progression; conformation; conformational state; cyclophilin; dimer; driving; experiment; experimental research; experimental study; gene product; immunophilin; in vivo; insight; liver cell adhesion molecule; malignancy; metaplastic cell transformation; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; oncosuppressor gene; pathway; programs; research study; social role; transcription factor; tumor initiation; tumor progression; tumor suppressor",Mechanism of b-catenin targeting to adhesive or transcriptional complexes,,76561,ZRG1,Special Emphasis Panel,,5,243774,
7752865,R01,GM,5,,01/01/2010,12/31/2010,PAR-03-106,5R01GM076569-04,,NIGMS:233209;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PITTSBURGH,UNITED STATES,BIOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"ZUCKERMAN, DANIEL M;",6159844;,5R01GM076569,01/15/2007,12/31/2010,"Accounting; Address; Affect; Affinity; Agonist; Alcohols, Octyl; Algorithms; Area; Back; Benchmarking; Best Practice Analysis; Binding; Binding (Molecular Function); Binding Site Domain; Binding Sites; Biological; Biological Models; Biophysics; C element; Cancer of Breast; Carbon; Cardiovascular Agents; Cardiovascular Drugs; Chemicals; Clinical; Collaborations; Combining Site; Complex; Computer Programs; Computer software; Computers; Cost Savings; Data; Distant; Docking; Dorsum; Drug Design; Drugs; Engineering; Engineerings; Ensure; Equilibrium; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Family; Free Energy; Freezing; Goals; Heptylcarbinols; Hydroxyoctanes; Individual; Investigators; Isoforms; Lead; Libraries; Ligand Binding Domain; Ligands; Location; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measures; Medication; Methods; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Models, Molecular; Molecular; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Models; Molecular Stereochemistry; Motivation; Nature; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Nucleic Acid Biochemistry, Molecular Modeling; Octanols; Octylic Alcohols; Osteoporosis; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Position; Positioning Attribute; Preparation; Principal Investigator; Procedures; Production; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Isoforms; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Receptor Protein; Relative; Relative (related person); Research; Research Personnel; Researchers; Roentgen Rays; Role; Sampling; Saving, Cost; Scheme; Series; Site; Software; Solubility; Solutions; Speed; Speed (motion); Spinal Column; Spine; Statistical Mechanics; Structure; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic Estrogen; Time; Universities; Update; Vertebral column; Washington; Work; X-Radiation; X-Rays; Xrays; backbone; balance; balance function; base; chemical group; clinical relevance; clinically relevant; computational studies; computer program/software; computer studies; computing resources; conformation; conformational state; cost; design; designing; drug candidate; drug/agent; experience; flexibility; gene product; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interest; malignant breast neoplasm; molecular dynamics; molecular mechanics; molecular modeling; novel; pathway; programs; receptor; receptor binding; scaffold; scaffolding; simulation; small molecule; social role; virtual; willingness","Toward Practical, Rigorous Binding Affinity Calculations",,76569,ZRG1,Special Emphasis Panel,,4,233209,
7745442,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM076710-04,,NIGMS:494418;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"WALKER, SUZANNE L.;",2210538;,5R01GM076710,01/11/2007,12/31/2010,"Animal Model; Animal Models and Related Studies; Anti-Infective Agents; Anti-Infective Drugs; Anti-Infectives; Anti-infective Preparation; AntiInfective Drugs; AntiInfectives; Antibiotic Agents; Antibiotic Drugs; Antibiotic Resistance; Antibiotics; Antiinfective Agents; Assay; Bacillus subtilis; Bacteria; Bambermycins; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Factors; Biology; Carbohydrates; Cell Function; Cell Process; Cell Wall; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemistry; Dependence; Development; Disaccharides; Drug Kinetics; E. faecalis; E.faecalis; Engineering; Engineerings; Enterococcus faecalis; Enzymes; Factor, Biologic; Family; Flavophospholipols; Fluorescence Polarization; Genetic Alteration; Genetic Change; Genetic defect; Glycans; High Throughput Assay; IC50; Individual; Inhibitory Concentration 50; Ions; Killings; Kinetic; Kinetics; Laboratories; Lead; Length; Libraries; Ligands; Measurement; Measures; Menomycin; Metals; Methods; Microorganisms, General; Miscellaneous Antibiotic; Moenomycins; Molecular Interaction; Murein; Mutation; Natural Products; Organism; Pb element; Peptidoglycan; Pharmacokinetics; Polysaccharides; Property; Property, LOINC Axis 2; Protein Region; Reporting; Research; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; S. aureus; S. faecalis; S.aureus; S.faecalis; Science of Chemistry; Scientist; Site; Staging; Staphylococcus aureus; Streptococcus Group D; Streptococcus faecalis; Structure; Subcellular Process; TM Domain; Transmembrane Domain; Transmembrane Region; Vancomycin; Work; antibiotic resistant; base; combat; communicable disease control agent; design; designing; enzyme biosynthesis; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; high throughput screening; inhibitor; inhibitor/antagonist; insight; living system; microorganism; model organism; polymerization; research study; resistant; small molecule",Mechanism and Inhibition of Bacterial Transglycosylases,,76710,SBCA,Synthetic and Biological Chemistry A Study Section,,4,494418,
7758724,R01,GM,5,,02/01/2010,01/31/2011,PA-06-119,5R01GM077176-04,,NIGMS:334399;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BUFFALO,UNITED STATES,,28,074025479,US,NY,14203,HAUPTMAN-WOODWARD MEDICAL RESEARCH INST,"MALKOWSKI, MICHAEL G;",1903452;,5R01GM077176,02/01/2007,01/31/2012,"(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor[{..}]oxygen oxidoreductase; 2-(Acetyloxy)benzoic Acid; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; Acetylation; Acetylsalicylic Acid; Active Sites; Adverse effects; Affect; Amino Acids; Anabolism; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Arachidonic Acid Cyclooxygenase; Arachidonic Acids; Arthritis; Aspergum; Aspirin; Autoregulation; Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; Bextra; Binding; Binding (Molecular Function); Biological; C element; COX; COX-1; COX-1 protein; COX-2 protein; COX1; COX2; COX2 enzyme; COX3; CYP; Cahill May Roberts brand of rofecoxib; Carbon; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Caribbean; Caribbean Sea Region; Caribbean region; Catalysis; Chemicals; Chemistry; Clinical; Complex; Crystallization; Cyclo-Oxygenase; Cyclo-Oxygenase-1; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 3; Cytochromes; Data; Detergents; Development; Dioxygenases; Disease; Disorder; Ecotrin; Eicosanoids; Empirin; Entericin; Enzymes; Exhibits; Extren; Family; Fatty Acid Cyclo-Oxygenase; Fatty Acid Cyclooxygenase; Fatty Acids; Fatty Acids, Polyunsaturated; Food; Generations; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; HETE; Health; Heumann brand of celecoxib; Homeostasis; Homology Modeling; Human; Human, General; Hydroperoxide Cyclase; Hydroxyeicosatetraenoic Acids; Immune response; Inflammatory; Invertebrata; Invertebrates; Invertebrates, General; Investigation; Investigators; Leukotrienes; Life Style; Lifestyle; Linoleate-Oxygen Oxidoreductase; Linoleate[{..}]oxygen 13-oxidoreductase; Linoleic Acids; Lipids; Lipoxidase; Lipoxins; Lipoxygenase; MSD brand of rofecoxib; Mack brand of celecoxib; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurin; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Merck Frosst brand of rofecoxib; Merck Sharp & Dhome brand of rofecoxib; Merck brand of rofecoxib; Methods; Mice; Modeling; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Murine; Mus; Mutagenesis; Mutagenesis, Site-Directed; Mutation; NSAIDs; Non-Steroidal Anti-Inflammatory Agents; Nonsteroidal Anti-Inflammatory Agents; Nonsteroidal Antiinflammatory Drug; O element; O2 element; Organ System, Cardiovascular; Organism-Level Process; Organismal Process; Oryza sativa; Oxygen; Oxygenases; PGH Synthase; PGH Synthase 1; PGH Synthase 2; PGH(2); PGH2; PGH2 Synthetase; PGHS-1; PGHS-2; PGHS2; PHS II; PHS1; PTGS1; PTGS2; Parke Davis brand of celecoxib; Perception; Pfizer brand of celecoxib; Pfizer brand of valdecoxib; Pharmacia Spain brand of celecoxib; Pharmacia brand of celecoxib; Pharmacia brand of valdecoxib; Physiologic Processes; Physiological Homeostasis; Physiological Processes; Plants; Plants, General; Play; Polyunsaturated Fatty Acids; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 9,11-epidioxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin G/H Synthase 1; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H Synthase; Prostaglandin H2; Prostaglandin H2 Synthase; Prostaglandin H2 Synthase 1; Prostaglandin H2 Synthase 2; Prostaglandin H2 Synthetase; Prostaglandin Production; Prostaglandin Synthase; Prostaglandin Synthetase; Prostaglandin-Endoperoxide Synthase; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostanoids; Proteins; Reaction; Renal function; Reproduction; Research Personnel; Researchers; Resolution; Rofecoxib; Role; Science of Chemistry; Searle brand of celecoxib; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Specificity; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Treatment Side Effects; Vascular, Heart; Vioxx; Vioxx Dolor; West Indies Region; aminoacid; arthritic; base; biosynthesis; carboxylate; carotene oxidase; celebrex; celecoxib; circulatory system; conformation; conformational state; coral; cyclo-oxygenase I; cyclo-oxygenase II; cyclooxygenase 1; cyclooxygenase 2; disease/disorder; gene product; genome mutation; host response; immunoresponse; inhibitor; inhibitor/antagonist; insight; interest; kidney function; lipid mediator; membrane structure; mutant; nonsteroidal anti-inflammatory drugs; novel; pathogen; polyunsaturated fatty acid; programs; prostaglandin H synthase-1; prostaglandin H synthase-2; protoporphyrin IX; side effect; social role; stereochemistry; structural biology; therapy adverse effect; treatment adverse effect; vascular inflammation",Structural Biology of Oxylipin Biosynthesis,,77176,BBM,Biochemistry and Biophysics of Membranes Study Section,,4,334399,
7753139,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM077197-04,,NIGMS:246917;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"MCGINNIS, WILLIAM JAMES;",1862384;,5R01GM077197,01/01/2007,12/31/2010,"Affect; Animals; Applications Grants; Assay; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Signaling; Cells; Chitin Synthase; Chitin-UDP Acetylglucosaminyltransferase; Cicatrix; Code; Coding System; Combining Site; DNA Binding; DNA Binding Interaction; DNA Molecular Biology; Defect; Drosophila; Drosophila genus; Embryo; Embryonic; Enhancers; Environment; Epidermis; Epistasis; Epistasis, Genetic; Epistatic Deviation; Fruit Fly, Drosophila; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Epistasis; Genetic Models; Genetic Screening; Genetic Transcription; Genetic defect; Genetic screening method; Genetics, Human; Glutaminyl-Peptide Gamma-Glutamyltransferases; Grant Proposals; Grants, Applications; Head; Healed; Health; Hereditary Disease; Horny Layer; Human; Human Genetics; Human, General; Injuries, Multiple; Injury; Insecta; Insects; Interaction Deviation; Intracellular Communication and Signaling; Invertebrates, Insects; Investigators; Larva; Learning; Liquid substance; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Models, Genetic; Molecular Biology; Molecular Disease; Multiple Trauma; Murine; Mus; Mutation; Pathway interactions; Prevention; Proepithelin Conversion to Epithelin and Wound Repair Control; Protein-Glutamine gamma-Glutamyltransferases; Protein-glutamine[{..}]amine gamma-glutamyltransferase; RNA Expression; Reactive Site; Receptor Signaling; Regulation; Regulatory Element; RegulatoryElement; Reporter; Research Personnel; Researchers; Response Elements; Scars; Sepsis; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Skin; Stratum corneum; Structure; TGM1 gene product; Testing; Transcription; Transcription, Genetic; Transglutaminases; UDP-N-acetyl-D-glucosamine[{..}]chitin 4-beta-N-acetylglucosaminyltransferase; Work; Wound Healing; Wound Repair; Wound Repair Pathway; Wounds, Multiple; biological signal transduction; bloodstream infection; epidermal type I transglutaminase; experiment; experimental research; experimental study; fluid; fruit fly; gene x gene interaction; genetic disorder; genetic epistases; genetic testing; genome mutation; healing; hereditary disorder; improved; keratinocyte; keratinocyte transglutaminase K; liquid; microbial; mutant; novel; pathogen; pathway; repair; repaired; research study; response; soft tissue; tissue repair; trans-N-Acetylglucosaminosylase; transcription factor; transglutaminase 1; transglutaminase K; transglutaminase TGM1; transglutaminase Type I; transglutaminase i; transglutaminase1; wound",Regulation of epidermal barrier wound repair,,77197,DEV1,Development - 1 Study Section,,4,246917,
7760967,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM077452-03,,NIGMS:318733;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,,02,064367329,US,PA,191112434,INSTITUTE FOR CANCER RESEARCH,"TULIN, ALEXEI V;",8349371;,5R01GM077452,03/15/2008,01/31/2013,"ADP ribosylation; ADP-Ribosyltransferase (Polymerizing); Address; Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose, homopolymer; Affinity; Affinity Chromatography; Agarose; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Bos taurus PARP protein; Casein Kinase TS; Casein Kinase-2; Cell Death, Programmed; Cells; Chimera Protein; Chimeric Proteins; Chromatin; Chromatography, Affinity; Complex; Confocal Microscopy; Core Protein; Coupled; DNA Damage Repair; DNA Repair; Data; Detection; Developmental Gene; Drosophila; Drosophila genus; Drugs; Enzymes; Flies; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Fruit Fly, Drosophila; Fusion Protein; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Gene, Developmental; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Processes; Genetic Transcription; Genetic defect; Goals; Growth and Development; Growth and Development function; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Heterochromatin; Histone H2A; Histones; In Vitro; Individual; Intermediary Metabolism; Isoforms; Knowledge; L-Serine; Liquid Chromatography; METBL; Maps; Mass Spectrum; Mass Spectrum Analysis; Measures; Medication; Metabolic Processes; Metabolism; Methods; Microscopy, Confocal; Modeling; Molecular Interaction; Mutate; Mutation; N-terminal; NAD+[{..}]poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase; NH2-terminal; Organism; PARP Polymerase; PARP protein; PARP protein, Bos taurus; PARS; Pathogenesis; Peptide Domain; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Photometry/Spectrum Analysis, Mass; Point Mutation; Poly ADP Ribose; Poly Adenosine Diphosphate Ribose; Poly(ADP-Ribose) Synthase; Poly(ADP-Ribose) Transferase; Poly(ADP-ribose) Polymerases; Poly(ADPR) Polymerase; Poly(ADPribose) Polymerase; Poly-ADPR; Process; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Cleavage; Protein Domains; Protein Isoforms; Protein Kinase CK2; Protein Kinase CKII; Protein Phosphorylation; Proteins; Proteolysis; Public Health; RNA Expression; Recombinants; Regulation; Relative; Relative (related person); Research Resources; Resources; Role; Saccharose; Sepharose; Serine; Site; Solutions; Specific qualifier value; Specified; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sucrose; System; System, LOINC Axis 4; Tail; Tertiary Protein Structure; Testing; Transcription; Transcription Activation; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Control; Transcriptional Regulation; Transgenic Organisms; Unscheduled DNA Synthesis; Up-Regulation; Variant; Variation; Work; affinity purification; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; casein kinase II; cross-link; crosslink; drug/agent; experiment; experimental research; experimental study; fly; fruit fly; gene product; genome mutation; in vitro Assay; in vivo; insight; living system; mutant; novel; poly ADP polymerase; poly ADP ribose synthetase; poly ADP-ribose glycohydrolase; programs; proline-arginine rich protein; protein activation; protein complex; protein structure; public health medicine (field); research study; social role; tandem mass spectrometry; therapeutic development; transgenic",Poly ADP-ribose Polymerase in Chromatin and Transcriptional Regulation,,77452,MGC,Molecular Genetics C Study Section,,3,318733,
7763236,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM077465-05,,NIGMS:473089;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,,08,623544785,US,MA,021421401,"BROAD INSTITUTE, INC.","MOOTHA, VAMSI KRISHNA;",8481417;,5R01GM077465,02/01/2007,01/31/2012,"Affect; Aging Process; Aging-Related Process; Apoptosis; Apoptosis Pathway; Atlases; Autoregulation; Body Tissues; Candidate Disease Gene; Candidate Gene; Cataloging; Catalogs; Causality; Cell Body; Cell Death, Programmed; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Clinical Medicine; Complement; Complement Proteins; Complex; Computational Biology; Cytosol; Data; Defect; Detection; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dysfunction; Equipment and supply inventories; Etiology; Foundations; Functional disorder; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genomics; Goals; Haplotypes; Health; Heart failure; Hereditary; Hereditary Metabolic Disorder; Homeostasis; Human; Human, General; Image; Inborn Errors of Metabolism; Inherited; Inventory; Investigators; Ions; Label; Link; MODY; Man (Taxonomy); Man, Modern; Maps; Maturity-Onset Diabetes Mellitus; Measures; Medical Sciences, Clinical; Metabolic Diseases; Metabolic Disorder; Metabolism, Inborn Errors; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Method LOINC Axis 6; Methodology; Microscopy; Mind; Mitochondria; Mitochondrial Diseases; Mitochondrial Disorders; Mitochondrial Proteins; Mutation; NIDDM; Nerve Degeneration; Neuron Degeneration; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nuclear; Nucleus; Organ System; Organelles; Pathogenesis; Pathway interactions; Pattern; Peptides; Physiological Homeostasis; Physiopathology; Play; Prevention; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biochemistry; Protein/Amino Acid Biochemistry; Proteins; Proteomics; Research Personnel; Research Resources; Researchers; Resources; Role; Shapes; Source; Stable Isotope Labeling; Steroid Compound; Steroids; Structure; Subcellular Process; Survey Instrument; Surveys; System; System, LOINC Axis 4; T2D; T2DM; Technology; Thesaurismosis; Tissues; Type 2 diabetes; Type II diabetes; Variant; Variation; Work; adult onset diabetes; base; body system; cardiac failure; cell body (neuron); cell type; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; fat metabolism; gene discovery; gene product; genome mutation; genome sequencing; genome, mammalian; human disease; imaging; inborn metabolism disorder; insight; interdisciplinary approach; interest; ketosis resistant diabetes; lipid metabolism; mammalian genome; maturity onset diabetes; metabolism disorder; mitochondrial; mitochondrial disease/disorder; mitochondrial dysfunction; neural cell body; neural degeneration; neurodegeneration; neuronal cell body; neuronal degeneration; novel; pathophysiology; pathway; programs; protein expression; social role; soma; tandem mass spectrometry; therapeutic target",A Comprehensive Proteomic Map of Mammalian Mitochondria,,77465,GCAT,"Genomics, Computational Biology and Technology Study Section",,5,473089,
7760194,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM077582-04,,NIGMS:155678;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ARLINGTON,UNITED STATES,BIOLOGY,24,064234610,US,TX,760190145,UNIVERSITY OF TEXAS ARLINGTON,"FESCHOTTE, CEDRIC ;",8231552;,5R01GM077582,02/01/2007,01/31/2012,"Address; Assay; Bioassay; Biologic Assays; Biological Assay; Callithrix; Candidate Disease Gene; Candidate Gene; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chromosomal Rearrangement; Chromosome Fragile Sites; DNA Recombination; DNA Transposons; DNA recombination (naturally occurring); Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Elements; Environment; Evolution; Evolution, Molecular; Expression Profiling; Expression Signature; Family; Fragile Site; GWAS; Gene variant; Genes; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Recombination; Genetic Variation; Genetic defect; Genome; Genome, Human; Genomics; Goals; Hapale; History; Human; Human Genome; Human, General; In Vitro; Macaca mulatta; Mammals, Primates; Man (Taxonomy); Man, Modern; Marmoset, Short-Tusked; Marmosets; Mediating; Molecular Evolution; Molecular Fingerprinting; Molecular Profiling; Movement; Mutation; Mutation Spectra; Orang-utan; Orangutan; Pongo pygmaeus; Population; Primates; Proteins; Proteome; Radiation; Recombination; Recombination, Genetic; Recording of previous events; Recruitment Activity; Research; Rhesus; Rhesus Macaque; Rhesus Monkey; SEQ-AN; Sequence Analyses; Sequence Analysis; Shapes; Source; Subcellular Process; Testing; Time; Transposase; Transposons, DNA; Variation (Genetics); allelic variant; body movement; clinical data repository; clinical data warehouse; comparative; comparative genomics; computational tools; computerized tools; data repository; gene product; genome mutation; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; human DNA; human tissue; in vivo; innovate; innovation; innovative; interest; molecuar profile; molecular signature; ray (radiation); recruit; relational database; transposon element; whole genome association studies; whole genome association study",Human DNA transposons: evolutionary history and genomic impact,,77582,GVE,Genetic Variation and Evolution Study Section,,4,155678,
7762834,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM077689-04,,NIGMS:306735;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"GILL, GRACE B;",1903416;,5R01GM077689,02/01/2007,01/31/2011,"APF-1; ATP-Dependent Proteolysis Factor 1; Address; Affinity Chromatography; Assay; Bacterial Infections; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Bone; Bone and Bones; Bones and Bone Tissue; CHIP assay; Cancers; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Structure; Chromatography, Affinity; Combining Site; Complex; Covalent Interaction; DNA-Dependent RNA Polymerase II; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Diabetes Mellitus; Disease; Disorder; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Foundations; Gene Action Regulation; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Genes; Genes, Reporter; Genetic Polymorphism; Genetic Transcription; Gills; HMG-20; Health; Hematopoietic; High Mobility Protein 20; Histones; Human; Human, General; Infection; Ligand Binding Protein; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modification; Molecular; Molecular Analysis; Molecular Interaction; Murine; Mus; Mutate; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; NuRD; NuRD complex; Osteoporosis; Pathogenesis; Pattern; Polymorphism (Genetics); Polymorphism, Genetic; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Post-Translational Modifications; Post-Translational Protein Processing; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Posttranslational Modifications; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Quelling; RNA Expression; RNA Interference; RNA Polymerase B; RNA Polymerase II; RNA Silencing; RNA Silencings; RNAi; Reactive Site; Recruitment Activity; Regulation; Reporter Genes; Reporting; Repression; Research; Role; SPR-2; SUMO Proteins; Sentrin Proteins; Sentrins; Sequence-Specific Posttranscriptional Gene Silencing; Small Ubiquitin-Related Modifier Proteins; Sp3 Transcription Factor; Structure; Targetings, Gene; Testing; Tooth; Tooth structure; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Ubiquitin; Viral; affinity purification; bacterial disease; base; bone; chromatin immunoprecipitation; cofactor; design; designing; diabetes; disease risk; disease/disorder; disorder risk; gene product; gene repression; human disease; in vivo; insight; malignancy; neoplasm/cancer; neurodegenerative illness; new therapeutics; next generation therapeutics; novel therapeutics; polymorphism; programs; recruit; social role; teeth; transcription factor",Mechanisms of transcriptional repression by SUMO,,77689,MGA,Molecular Genetics A Study Section,,4,306735,
7760191,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM079182-03,,NIGMS:321750;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,BIOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"EMERY, PATRICK ;",7034794;,5R01GM079182,04/01/2008,01/31/2012,"Accidents; Address; Affect; Affective Disorders; Algae, Blue-Green; Animal Model; Animal Models and Related Studies; Animals; Attention; Behavior; Behavioral; Behavioral Genetics; Blue-Green Bacteria; Circadian Rhythms; Complex; Cues; Cyanobacterium; Cyanophyceae; Cyanophyta; Data; Disease; Disorder; Diurnal Rhythm; Drosophila; Drosophila genus; Drosophila melanogaster; Elements; Environment; Eukaryota; Eukaryote; Flies; Fruit Fly, Drosophila; Future; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinants of Behavior; Genetic defect; Genetics, Behavioral; Health; Human; Human, General; Jet Lag; Jet Lag Syndrome; Jetlag; Jetlag Syndrome; Life; Light; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Medical; Mental disorders; Mental health disorders; Molecular; Molecular Genetic; Molecular Genetics; Mood Disorders; Mutation; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurosciences; Nyctohemeral Rhythm; Organism; Pace Stimulators; Pacemakers; Pathway interactions; Phase; Photoradiation; Physiologic; Physiological; Physiology; Play; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Regulation; Role; Seasonal Affective Disorder; Seasonal Mood Disorder; Solutions; Stimulators, Electrical, Pace; Stimulus; Structure; Temperature; Testing; Thermoreceptors; Time; Time Zone Change Syndrome; Time Zone Syndrome; Twenty-Four Hour Rhythm; Unspecified Mental Disorder; Variant; Variation; Work; abstracting; base; behavior genetics; circadian; circadian behavioral rhythms; circadian clock; circadian pacemaker; circadian process; daily biorhythm; day length; day shift; disease/disorder; diurnal variation; eukaryotida; fly; fruit fly; genome mutation; intervention design; light intensity; living system; mental illness; model organism; neuronal; night shift; night work; novel; pathway; psychological disorder; response; seasonal depression; shift work; social role; temperature receptor; therapy design; treatment design",Synchronization of Drosophila Circadian Rhythms by temperature cycles,,79182,ZRG1,Special Emphasis Panel,,3,321750,
7760873,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM079207-04,,NIGMS:383997;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLACKSBURG,UNITED STATES,BIOLOGY,09,003137015,US,VA,24060,VIRGINIA POLYTECHNIC INST AND ST UNIV,"TYSON, JOHN J;",1947101;,5R01GM079207,02/01/2007,01/31/2011,"0-6 weeks old; Accounting; Address; Adenovirus E1A-Associated Protein p60; Affect; Biochemistry; Biological; Birth Defects; CDK; Cancer Induction; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Cycle Stage; Cell Division Cycle; Cell Signaling; Cell Size; Cell division; Cells; Cellular Expansion; Cellular Growth; Chemistry, Biological; Chromosomes; Computing Methodologies; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Consult; Cyclin A; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; DNA; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; Data; Deoxyribonucleic Acid; Development; Disease; Disorder; E1A p60; EC 2.7; Embryo Development; Embryogenesis; Embryonic Development; Endomycetales; Equilibrium; Eukaryota; Eukaryote; Eukaryotic Cell; Event; Family; Fission Yeast; Foundations; Frog; GFAC; GWAS; Gene Expression; Gene Proteins; Generalized Growth; Genes; Genetic; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Health; Hereditary; Human; Human, General; Individual; Infant, Newborn; Inherited; Institutes; Intracellular Communication and Signaling; Investigators; Kinases; Laboratories; Life; M Phase; M phase (cell cycle); Mad1 protein; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Maps; Math Models; Measures; Metaphase; Methods; Mitosis; Mitosis Stage; Mitotic; Mitotic Metaphase; Mitotic spindle; Modeling; Molecular; Molecular Genetic; Molecular Genetic Abnormality; Molecular Genetics; Newborn Infant; Newborns; Nutritional status; Organism; Pathway interactions; Pattern; Phase; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiologic; Physiological; Plant Roots; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Gene Products; Proteins; Rana; Rana (genus); Relative; Relative (related person); Reproduction; Research Personnel; Researchers; Role; S cerevisiae; S pombe; Saccharomyces cerevisiae; Saccharomycetales; Schizosaccharomyces pombe; Science; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solid; System; System, LOINC Axis 4; Testing; Theoretical Studies; Time; Tissue Growth; Translating; Translatings; Transphosphorylases; Uncertainty; Universities; Virginia; Wound Healing; Wound Repair; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeast, Fission; YeastModel; Yeasts; balance; balance function; base; biological signal transduction; carcinogenesis; cdk Proteins; cell growth; cell type; computational methodology; computational methods; computational studies; computer methods; computer studies; cost; disease/disorder; doubt; eukaryotida; experiment; experimental research; experimental study; gene product; genome sequencing; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; improved; language translation; living system; mad1 gene product; malignancy; mathematical model; mathematical modeling; mitotic arrest deficient protein 1; molecular oncology; neoplasm/cancer; newborn human (0-6 weeks); novel; ontogeny; p60 (cyclin A); pathway; programs; protein complex; regenerate new tissue; regenerating damaged tissue; research study; response; root; simulation; social role; success; theories; tissue regeneration; tissue repair; tool; whole genome association studies; whole genome association study",Experimental and Computational Studies of Exit from Mitosis in Budding Yeast,,79207,MABS,Modeling and Analysis of Biological Systems Study Section,,4,383997,
7759140,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM079242-04,,NIGMS:265073;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATLANTA,UNITED STATES,ANATOMY/CELL BIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"MOBERG, KENNETH H;",1883305;,5R01GM079242,02/01/2007,01/31/2011,"ATF; Antimorphic mutation; Binding; Binding (Molecular Function); Biochemical Genetics; Biological; Biological Models; Blood Vessels; Body Tissues; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Chemoattractants; Chemotactic Factors; Chemotaxins; Crossmatching, Tissue; Cyclin E; DNA Synthesis Factor; Data; Defect; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drosophila; Drosophila genus; Drosophila melanogaster; Duct; Duct (organ) structure; E3 Ligase; E3 Ubiquitin Ligase; ECGF; Embryo; Embryonic; Endothelial Cell Growth Factor; Epithelial; Eye; Eyeball; F-Box Domain Protein; F-Box Protein Family; F-Box Proteins; FGF; Family; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Flies; Fruit Fly, Drosophila; Genes; Genetic Techniques; Genetic screening method; Genetic, Biochemical; Goals; HBGF; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Histocompatibility Testing; Human; Human, General; Hypoxia Inducible Factor; Investigators; Knowledge; Ligase; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mitotic; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Morphogenesis; Morphology; O element; O2 element; Oncogenesis; Oncogenic; Ortholog; Orthologous Gene; Oxygen; Pathway interactions; Play; Process; Programs (PT); Programs [Publication Type]; Proteins; Recruitment Activity; Research Personnel; Researchers; Role; Specificity; Synthetases; System; System, LOINC Axis 4; Technics, Genetic; Testing; Tissue Crossmatchings; Tissue Typing; Tissues; Transgenes; Tube; Ubiquitilation; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Unpublished Works (PT); Unpublished Works [Publication Type]; Work; activating transcription factor; base; complement chemotactic factor; expectation; fly; fruit fly; gene function; gene product; genetic testing; histocompatibility typing; hypoxia inducible factor 1; knock-down; lung development; member; mutant; novel; pathway; programs; recruit; social role; transcription factor; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase; unpublished works; vascular",Role of the Archipelago gene in Drosophila tracheal morphogenesis,,79242,DEV2,Development - 2 Study Section,,4,265073,
7772282,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM079431-05,,NIGMS:302445;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WORCESTER,UNITED STATES,BIOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"BAEHRECKE, ERIC H;",1866347;,5R01GM079431,02/01/2007,01/31/2011,"1-Phosphatidylinositol 4-Kinase; 21+ years old; ATP[{..}]1-phosphatidyl-1D-myo-inositol-4-phosphotransferase; Adult; Animals; Apoptosis; Apoptosis Pathway; Autophagocytosis; Autoregulation; Biological Metamorphosis; Body Tissues; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Death; Cell Death Process; Cell Death, Programmed; Cell Division Cycle; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cell-Death Protease; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Morphology; Cellular Physiology; Cellular Process; Cessation of life; Death; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Disease; Disorder; Drosophila; Drosophila genus; Drosophila melanogaster; EC 2.7; EC 2.7.1.67; Esteroproteases; Flies; Fruit Fly, Drosophila; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genotype; Growth; Head and Neck, Salivary Glands; Homeostasis; Homolog; Homologous Gene; Homologue; Human; Human, Adult; Human, General; ICE-like protease; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigators; Kinases; Larva; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Man (Taxonomy); Man, Modern; Metamorphosis, Biological; Modeling; Mutation; NPIK; Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Organism; PI 4-Kinase; PI4K-Beta; PI4K92; PI4KBeta; PIK4CB; Pathway interactions; Peptidases; Peptide Hydrolases; Phosphatidyl Inositol; Phosphatidylinositiol Kinase; Phosphatidylinositol 4-Kinase; Phosphatidylinositol 4-Kinase Beta; Phosphatidylinositol 4-Kinase, Catalytic, Beta; Phosphatidylinositol 4-Kinase, Type III, Beta; Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive; Phosphatidylinositol Kinase Type II; Phosphatidylinositols; Phosphoinositide Kinase; Phosphoinositide-4-Kinase Catalytic Beta Polypeptide; Phosphoinositides; Phosphotransferases; Physiological Homeostasis; Play; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; PtdIns; PtdIns 4-Kinase; Regulation; Research Personnel; Researchers; Role; Salivary Glands; Signal Transduction; Signal Transduction Systems; Signaling; Steroid Compound; Steroids; Subcellular Process; Therapeutic Steroid Hormone; Time; Tissue Growth; Tissues; Transphosphorylases; Yeasts; adult human (21+); animal tissue; autophagy; biological signal transduction; caspase; cell growth; cell morphology; cystein protease; cystein proteinase; cysteine endopeptidase; disease/disorder; fly; fruit fly; gene function; genome mutation; living system; malignancy; metamorphosis; mutant; necrocytosis; neoplasm/cancer; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; ontogeny; pathway; prevent; preventing; programs; social role; steroid hormone",Genetic regulation of autophagic cell death,,79431,ZRG1,Special Emphasis Panel,,5,302445,
7765560,R01,GM,5,,02/01/2010,01/31/2011,PAR-03-045,5R01GM079613-04,,NIGMS:251609;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBIA,UNITED STATES,NONE,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"GU, LI-QUN ;",8605036;,5R01GM079613,02/01/2007,01/31/2012,"AIDS Virus; Address; Affinity; Aptamer Technology; Area; Binding; Binding (Molecular Function); Biological Function; Biological Process; Biomedical Engineering; Biomedical Technology; Biotechnology; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemical Engineering; Complex; DISSEC; DNA Fingerprinting; DNA Profiling; DNA Profilings; DNA Typing; Detection; Dimensions; Disease; Disorder; Dissection; Engineering; Engineerings; Environmental Engineering technology; Fingerprintings, DNA; Frequencies (time pattern); Frequency; Gene Expression; Gene Products, RNA; Generations; Goals; Grippe; HIV-1; HIV-1 Reverse Transcriptase; HIV-I; HIV1; High Throughput Assay; Human immunodeficiency virus 1; IgE; Immunodeficiency Virus Type 1, Human; Immunoglobulin E; Influenza; Ions; Laboratories; Lead; Life; Ligands; Light; Mediating; Modeling; Molecular; Molecular Interaction; Nanoscale Science; Nanotechnology; Nucleic Acids; Osmosis; Pb element; Photoradiation; Property; Property, LOINC Axis 2; Proteins; RNA; RNA, Non-Polyadenylated; Reagent; Receptor Protein; Research; Ribonucleic Acid; Science; Solutions; Subcellular Process; Surface; Technology; Testing; V (voltage); Viral; aptamer; base; bioengineering; bioengineering/biomedical engineering; biological systems; bionano technology; bionanotechnology; chemical reaction; design; designing; detector; disease/disorder; environmental engineering; flu infection; gene product; heavy metal Pb; heavy metal lead; high throughput screening; human T cell leukemia virus III; human T lymphotropic virus III; improved; influenza infection; molecular scale; nano; nano biotechnology; nano fabricate; nano fabrication; nano medicine; nano meter scale; nano meter sized; nano pore; nano scale; nano scale Science; nano tech; nano technology; nanobiotechnology; nanofabricate; nanofabrication; nanomedicine; nanometer scale; nanometer sized; nanopore; nanoscale; nanotech; new therapeutics; next generation therapeutics; novel therapeutics; particle; pathogen; protein protein interaction; receptor; single molecule; success; tool; voltage",Programmable Multi-Target Detection Using an Aptamer-Integrated Nanopore,,79613,ZRG1,Special Emphasis Panel,,4,251609,
7758272,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM079663-04,,NIGMS:245057;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,AMES,UNITED STATES,BIOCHEMISTRY,04,005309844,US,IA,500112207,IOWA STATE UNIVERSITY,"SHOGREN-KNAAK, MICHAEL AARON;",8552675;,5R01GM079663,02/01/2007,01/31/2012,"APF-1; ATP-Dependent Proteolysis Factor 1; Acetylation; Address; Affect; Area; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Models; Biological Process; Birth Defects; C-terminal; Cancers; Charge; Chemicals; Chromatin; Chromatin Assembly; Chromatin Modeling; Chromatin Structure; Closure by Ligation; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cysteine; DNA Damage Repair; DNA Repair; Data; Development; Disease; Disorder; Enzyme Kinetics; Exhibits; Gene Transcription; Genetic; Genetic Transcription; Goals; HMG-20; Half-Cystine; High Mobility Protein 20; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Histone Acetylation; Histone H2A; Histone H2B; Histone H3; Histone H4; Histones; In Vitro; Individual; Investigators; L-Cysteine; L-Lysine; Label; Lead; Ligation; Lysine; Malignant Neoplasms; Malignant Tumor; Mediating; Methods; Methods and Techniques; Methods, Other; Methylation; Model System; Models, Biologic; Modification; Molecular Genetic Abnormality; Molecular Interaction; Monoubiquitination; Nucleosomes; Pattern; Pb element; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Protein Methylation; Proteins; RNA Expression; Regulation; Research; Research Personnel; Researchers; Role; SAGA; SPT/ADA/Gcn5 Acetyltransferase; Site; Structure; Tail; Techniques; Testing; Transcription; Transcription, Genetic; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Unscheduled DNA Synthesis; Work; Yeasts; cartilage link protein; chromatin modification; disease diagnosis; disease/disorder; enzyme activity; experience; gene product; heavy metal Pb; heavy metal lead; histone modification; in vivo; link protein; malignancy; neoplasm/cancer; novel; programs; social role; ubiquination; ubiquitin conjugation",Histone Modifications and Higher-Order Chromatin Structure,,79663,MGA,Molecular Genetics A Study Section,,4,245057,
7755390,R01,GM,5,,02/01/2010,01/31/2011,PAR-03-106,5R01GM079688-04,,NIGMS:248003;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EAST LANSING,UNITED STATES,ENGINEERING (ALL TYPES),08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"CHAN, CHRISTINA ;",7145526;,5R01GM079688,02/01/2007,01/31/2011,"Algorithms; Animals; Bayesian Networks; Cell Culture System; Cell Culture Techniques; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Common Rat Strains; Computer Simulation; Computerized Models; Data; Diet; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Environment; Fats; Fatty acid glycerol esters; Feedback; Gene Expression; Gene Inactivation; Gene Silencing; Genes; Genes, Regulator; INFLM; Inflammation; Knowledge; Liver; Mammals, Rats; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Metabolic; Modeling; Models, Computer; Ontology; Pathway interactions; Phenotype; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rat; Rattus; Regulator Genes; Sequence-Specific Posttranscriptional Gene Silencing; Series; Simulation, Computer based; Structure; Subcellular Process; TXT; Text; Time; Transcriptional Regulatory Elements; Transfection; Triacylglycerol; Triglycerides; body system, hepatic; computational modeling; computational models; computational simulation; computer based models; computer based statistical methods; computerized modeling; computerized simulation; cost effectiveness; discovery mining; disease/disorder; experiment; experimental research; experimental study; feeding; improved; in silico; in vivo; literature mining; literature searching; new approaches; nonalcoholic steatohepatitis; novel approaches; novel strategies; novel strategy; organ system, hepatic; pathway; reconstruction; regulatory gene; research study; response; statistical methods, computer based; text mining; text searching; trans acting element; virtual simulation",Develop a Dynamic Model that Incoporates Text-mining to Reconstruct Networks,,79688,BDMA,Biodata Management and Analysis Study Section,,4,248003,
7754050,R01,GM,5,,01/01/2010,12/31/2010,,5R01GM080214-11,,NIGMS:309672;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"LYBRAND, TERRY P;",1894948;,5R01GM080214,06/01/1995,12/31/2010,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 5,6,7,8-Tetrahydrofolate[{..}]NADP+ oxidoreductase; Active Sites; Affinity; Behavior; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Biological Models; Biology; Biotin; Calorimetry; Carbamoyl Transferases; Catalysis; Characteristics; Collection; Combining Site; Complex; Coupled; Covalent Interaction; DHFR; Dihydrofolate Dehydrogenase; Dihydrofolate Reductase; Dissociation; Distal; Drug Design; EC 1.5.1.3; Enzymes; Equilibrium; Event; Folic Acid Reductase; Free Energy; Funding; GeneHomolog; Genetic Alteration; Genetic Change; Genetic defect; Hemoglobin; Homolog; Homologous Gene; Homologue; Hydrogen Oxide; Investigators; Lead; Ligand Binding; Ligand Binding Protein; Ligands; Maps; Measurable; Measurement; Measures; Model System; Models, Biologic; Molecular Dynamics Simulation; Molecular Interaction; Mutation; Pb element; Play; Point Mutation; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Reaction; Reactive Site; Research Personnel; Researchers; Resolution; Role; Site; Sites, Active; Strepavidin; Streptavidin; Structural Protein; Structure; System; System, LOINC Axis 4; Temperature; Testing; Tetrahydrofolate Dehydrogenase; Thermodynamic; Thermodynamics; Vitamin H; Water; balance; balance function; base; biotin-streptavidin complex; carbamoyltransferase; coenzyme R; design; designing; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; molecular dynamics; molecular recognition; mutant; programs; protein structure; research study; simulation; social role; transcarbamoylase",Molecular recognition in the streptavidin-biotin system,,80214,ZRG1,Special Emphasis Panel,,11,309672,
7748963,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM080506-02,,NIGMS:239256;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,CHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"SHEA, KENNETH J;",1883875;,5R01GM080506,01/01/2009,12/31/2012,"Affinity; Amino Acid Sequence; Amino Acids; Animals; Antibodies; Antibody-Producing Cells; Antigenic Determinants; Binding; Binding (Molecular Function); Binding Determinants; Bio-Informatics; Bioinformatics; Biological; Biomedical Research; Biosensor; Blood Plasma; Buffers; Cancers; Cell Line; Cell Lines, Strains; CellLine; Characteristics; Cherries; Cherry - dietary; Clinical; Collaborations; Complex; DNA; Deoxyribonucleic Acid; Development; Diagnostic; Dialysis; Dialysis procedure; Disease; Disorder; Enzymes; Epitopes; Exhibits; Film; Gamma Globulin, 7S; Genomics; Glass; Goals; IgG; Immunoglobulin G; Immunoglobulin-Producing Cells; In Vitro; Infection; Institutes; Lead; Length; Life; Malignant Neoplasms; Malignant Tumor; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Interaction; Pb element; Peptide Domain; Peptide Fragments; Peptide Receptor; Peptides; Performance; Plasma; Plastics; Polymers; Precipitation; Preparation; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Domains; Protein Structure Databases; Protein Structure, Primary; Proteins; Quartz; Quartz (SiO2); Reaction; Reagent; Receptor Protein; Research; Reticuloendothelial System, Serum, Plasma; Serum, Plasma; Si element; Silicon; Site; Solutions; Specificity; Structure; Structure Databases, Protein; Surface; Suspension substance; Suspensions; System; System, LOINC Axis 4; Techniques; Tertiary Protein Structure; Therapeutic; Toxin; aminoacid; aminoacid sequence of peptide; aminoacid sequence of protein; analytical tool; base; biomarker; cost; cultured cell line; design; designing; dialysis therapy; disease diagnosis; disease/disorder; gene product; heavy metal Pb; heavy metal lead; imprint; macromolecule; malignancy; monomer; nano particle; nano sized; nanoparticle; nanosized; neoplasm/cancer; particle; peptide sequence; peptide structure; polymerization; professor; programs; protein aminoacid sequence; protein purification; protein sequence; protein structure; public health relevance; receptor; sensor (biological); suspension",Selective Protein Capture by Epitope Imprinting," Project Narrative  Antibodies are important reagents that are used in biomedical research, in diagnosis of diseases, and in treatment of such diseases as infections and cancer. Antibodies are produced by cell lines or clones obtained from animals that have been immunized with the substance that is the target of study. We propose to develop a method for producing robust, inexpensive, non-biological polymer antibodies that can be used as substitutes for native antibodies.",80506,SBCA,Synthetic and Biological Chemistry A Study Section,,2,239256,
7760533,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM080568-03,,NIGMS:265949;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,BIOCHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"CAMPBELL, SHARON L;",1902899;,5R01GM080568,02/15/2008,01/31/2012,"ATP[{..}]protein-tyrosine O-phosphotransferase; Actins; Adaptor Protein; Adaptor Signaling Protein; Adhesion Molecule; Adhesion Plaques; Adhesions; Affinity; Animal Welfare; Anoikis; Bacteriophages; Bibliography; Binding; Binding (Molecular Function); Binding Site Domain; Biochemical; Biological; Budgets; C-terminal; Cell Adhesion; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Mobility; Cell Movement; Cell Protection; Cell Signaling; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cells; Cellular Adhesion; Cellular Migration; Cellular Mobility; Chemicals; Collaborations; Country; Coupled; Cytoprotection; DNA Sequence Rearrangement; Data; EC 2.7; ECM; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Ecological impact; Environment; Environmental Impact; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Equipment; Ethics Committees, Research; Event; Extracellular Matrix; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinase Gene; FAK; FAK1; Florida; Focal Adhesion Kinase 1; Focal Adhesions; Focal Contacts; Funding; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; H element; HEK3; Human Cancer Pathology; Human Resources; Hydrogen; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Integrins; International; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinases; Kinetic; Kinetics; L-Tyrosine; Label; Libraries; Ligand Binding; Ligand Binding Domain; Light; Link; MAP Kinase Gene; MAPK; Manpower; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediating; Metastatic to; Method LOINC Axis 6; Methodology; Minor; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; Monitor; Motility; Motility, Cellular; Mutagenesis, Site-Directed; Mutation; Nature; Nuclear Magnetic Resonance; PTK; PTK Receptors; PTK2; PTK2 Protein Tyrosine Kinase 2; Peptides; Phages; Phenotype; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Photoradiation; Physiologic; Physiological; Play; Preparation; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RTK; Rearrangement; Receptor Protein-Tyrosine Kinases; Regulation; Relaxation; Research; Research Ethics Committees; Research Resources; Resources; Role; Route; Sampling; Series; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Solutions; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spinal Column; Spine; Structure; TYR; Targeted DNA Modification; Targeted Modification; Time; Transmembrane Receptor Protein Tyrosine Kinase; Transmission; Transphosphorylases; Tyrosine; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Phosphorylation; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; Vascular Diseases; Vascular Disorder; Vertebral column; Vertebrate Animals; Vertebrates; abstracting; backbone; bacterial virus; base; biological signal transduction; blood vessel disorder; cell adhesion protein; cell motility; computational studies; computer studies; conformation; conformational state; conformer; data exchange; design; designing; drug development; endogenous substrate pp120; experiment; experimental research; experimental study; expiration; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; gene product; genome mutation; human subject; hydroxyaryl protein kinase; in vivo; interest; interventional strategy; molecular dynamics; mutant; novel; p125(FAK); p125FAK; para-Tyrosine; paxillin; personnel; phosphatase inhibitor; pp125(FAK); pp125FAK; prevent; preventing; programs; protein protein interaction; protein structure; research study; response; scaffold; scaffolding; social role; transmission process; tyrosyl protein kinase; vertebrata",Conformational dynamics and focal adhesion kinase function,,80568,ZRG1,Special Emphasis Panel,,3,265949,
7759527,R01,GM,5,,02/01/2010,01/31/2011,,5R01GM080751-23,,NIGMS:265592;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,OMAHA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"RIZZINO, ARNOLD ANGIE;",1867858;,5R01GM080751,08/01/1985,01/31/2011,"Binding Sites; Cancer Biology; Cells; Combining Site; DNA Binding; DNA Binding Interaction; Development; Developmental Biology; ES cell; Embryo Development; Embryogenesis; Embryonic Development; Enhancers; Ensure; Exhibits; FGF-4; FGF4; Feedback; Fibroblast Growth Factor 4; GFAC; Gene Targeting; Gene Transcription; Genes; Genes, Regulator; Genetic Transcription; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF-4; K-FGF; K-fgf proto-oncogene; Kaposi fibroblast growth factor; Kaposi's sarcoma FGF; Molecular; Mother Cells; Play; Progenitor Cells; RNA Expression; Reactive Site; Regenerative Medicine; Regulation; Regulator Genes; Role; Stem cells; Targetings, Gene; Testing; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Transforming Protein KS3; Work; base; embryonic stem cell; heparin secretory transforming protein-1; hst-1 (heparin secretory transforming protein-1); insight; novel; oncogene protein hst-1; overexpression; proto-oncogene protein kfgf; regulatory gene; self-renewal; social role; stem cell of embryonic origin; trans acting element; transcription factor",Regulation of Growth Factors and Embryogenesis,,80751,DEV2,Development - 2 Study Section,,23,265592,
7759575,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM080754-02,,NIGMS:276210;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATLANTA,UNITED STATES,BIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"CROUSE, GRAY F.;",1895575;,5R01GM080754,02/01/2009,01/31/2013,"Active Oxygen; Affect; Aging; Animal Model; Animal Models and Related Studies; Assay; Base Pair Mismatch; Base Pairing; Base-Base Mismatch; Bioassay; Biochemistry; Biologic Assays; Biological Assay; Bypass; Cancers; Cells; Chemistry, Biological; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Proofreading; DNA Repair; DNA Replication; DNA Replication Proofreading; DNA Synthesis; DNA biosynthesis; Defect; Deoxyribonucleic Acid; Diagnostic; Disease; Disorder; Electromagnetic Radiation, Ionizing; Eukaryota; Eukaryote; Eukaryotic Cell; Frame Shift Mutation; Frameshift Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genome; Genome Instability; Genome Stability; Genomic Instability; Goals; Health; Hereditary; Human; Human, General; In Vitro; Inherited; Ionizing radiation; Lead; Lesion; Literature; Location; MMR; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mismatch Repair; Molecular Biology, Mutagenesis; Mutagenesis; Mutation; Nature; Oligo; Oligonucleotides; Outcome; Oxygen Radicals; Pathway interactions; Pb element; Play; Post-Replication Mismatch Repair; Pro-Oxidants; Process; Radiation; Radiation induced damage; Radiation-Ionizing Total; Reactive Oxygen Species; Reading Frame Shift Mutation; Replication Origin; Research; Role; S cerevisiae; Saccharomyces cerevisiae; Senescence; Stability, Genomic; System; System, LOINC Axis 4; Time; Translating; Translatings; Unscheduled DNA Synthesis; Yeast, Baker's; Yeast, Brewer's; Yeasts; base; design; designing; disease/disorder; eukaryotida; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; human disease; in vivo; interest; language translation; malignancy; model organism; neoplasm/cancer; novel; ori Region; oxidative damage; pathway; prevent; preventing; public health relevance; ray (radiation); repair; repaired; research study; response; senescent; social role; tool",Cellular Responses to Radiation and Other Types of Damage," Inherited defects in mismatch repair are responsible for the most common form of inherited colon cancer and defects in mismatch repair are found in many other cancers. Oxidative damage is one of the most common forms of damage to DNA and has been implicated in aging, cancer, and other diseases. Understanding how oxidative damage causes mutations, and the repair processes that act on it, such as mismatch repair, is extremely important in developing diagnostics and treatments.",80754,RTB,Radiation Therapeutics and Biology Study Section,,2,276210,
7760586,R01,GM,5,,02/01/2010,01/31/2011,HL-05-019,5R01GM080783-04,,NIGMS:290615;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"MCMANUS, MICHAEL T;",7019851;,5R01GM080783,02/01/2007,01/31/2012,"Adoption; Biology; Body Tissues; Bypass; Cell Nucleus; Cells; Complex; DICER1; DICER1 Protein; DICER1 protein, human; DNA; DNA Helicases; DNA Sequence; DNA Unwinding Proteins; DNA unwinding enzyme; Data; Dcr-1 Homolog; Deoxyribonucleic Acid; Dicer; Dicer Enzyme; Dicer1, Dcr-1 homolog (Drosophila) protein, human; Double-Stranded RNA; EC 3.1.26.-; Endoribonuclease Dicer; Enzyme, Dicer; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; Genes; Goals; HERNA; HERNA protein, human; Heart; Helicase with RNase Motif; Helicase-MOI; Heterochromatin; Homolog of Drosophila Dicer; Intervention; Intervention Strategies; Investigators; K12H4.8-Like; KIAA0928; Laboratories; Language; Libraries; Mammals, Mice; Mediating; Methods; Mice; Micro RNA; MicroRNAs; Modeling; Murine; Mus; Nucleus; ORFs; Open Reading Frames; Organism; Pathway interactions; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Coding Region; Quelling; RNA Interference; RNA Interference Pathway; RNA Silencing; RNA Silencings; RNA polymerase III transcription; RNA, Double-Stranded; RNA, Small Interfering; RNAi; Reporting; Repression; Research Personnel; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Site; Small Interfering RNA; Small RNA; System; System, LOINC Axis 4; Technology; Therapeutic; Therapeutic Intervention; Time; Tissues; Translational Inhibition; Translational Repression; design; designing; dsRNA; experiment; experimental research; experimental study; frontier; helicase; human DICER1 protein; human disease; insight; intervention therapy; interventional strategy; living system; miRNA; mouse model; novel; pathway; prevent; preventing; reagent testing; research study; sensor; shRNA; short hairpin RNA; siRNA; small hairpin RNA; social role; therapeutic development; tool; uptake",New Frontiers for Small RNA Therapies,,80783,ZRG1,Special Emphasis Panel,,4,290615,
7796815,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM081420-02,,NIGMS:305648;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CLEVELAND,UNITED STATES,BIOCHEMISTRY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"CAREY, PAUL R;",1902265;,5R01GM081420,04/01/2009,01/31/2013,"1,3,5,7-Tetraazatricyclo(3.3.1.13,7)decane; 1H-Purin-6-amine; 2-Amino-6-Hydroxypurine; 3-D structure; 3-dimensional structure; 3D structure; 6H-Purin-6-one, 2-amino-1,7-dihydro-; 7S RNA; 7S RNA, signal recogniton particle; 7SL RNA; Active Sites; Adenine; Bacteriophages; Binding; Binding (Molecular Function); Binding Sites; Biological Function; Biological Process; CIS protein; CIS-1 Protein; CISH; CISH Protein; Catalysis; Catalytic RNA; Cations; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chemicals; Chemistry; Clinic; Clinical; Co element; Cobalt; Collaborations; Combining Site; Complex; Crystallographies; Crystallography; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytokine Inducible SH2-Containing Protein; Cytokine-Inducible Inhibitor of Signaling Type 1B; Cytoplasm; DNA; Data; Delta Agent; Delta Virus; Deoxyribonucleic Acid; Dependency; Dependency (Psychology); Disease; Disorder; Drug Design; Electromagnetic, Laser; Electrostatics; Endoplasmic Reticulum; Enzymes; Ergastoplasm; Foundations; Frequencies (time pattern); Frequency; Functional RNA; G18; Gene Probes, RNA; Gene Products, RNA; Genetic Alteration; Genetic Change; Genetic Code; Genetic defect; Goals; Guanine; Guanosine; Heart; Hepatitis D Virus; Hepatitis Delta Virus; Hexamethylenetetramine; Hexamine; Imidazole; Individual; Intervening Sequences; Intracellular Communication and Signaling; Introns; Ions; Isotopes; Knowledge; Label; Laboratories; Lasers; Lead; Libraries; Life; Link; Location; Low Molecular Weight Nuclear RNA; Magnesium; Measures; Membrane; Messenger RNA; Metals; Methenamine; Methods; Methods and Techniques; Methods, Other; Mg element; Microscope; Microscopy; Modality; Modeling; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Mutate; Mutation; Nature; Non-Coding; Non-Coding RNA; Nucleotides; Nucleus; Pb element; Peptide Biosynthesis, Ribosomal; Phages; Phase; Phe-tRNA; Phenylalanine-Specific tRNA; Phosphates; Play; Population; Position; Positioning Attribute; Pre-mRNA; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; RNA; RNA Binding; RNA Probes; RNA Splicing; RNA, Messenger; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; RNA, Transfer, Phe; Radiation, Laser; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Raman Spectroscopy; Raman Spectrum Analysis; Raman spectrometry; Reaction; Reactive Site; Regulation; Relative; Relative (related person); Research; Research Technics; Resolution; Ribonucleic Acid; Ribosomal RNA; Ribosomes; Ribozymes; Roentgen Rays; Role; Running; SOCS; SRP; Samarium; Science of Chemistry; Signal Recognition Particle; Signal Transduction; Signal Transduction Systems; Signaling; Single Crystal Diffraction; Site; Sites, Active; Small Molecular Weight RNA; Small Nuclear RNA; Small RNA; Solutions; Spectroscopy; Spectroscopy, IR/UV/Raman; Spectrum Analyses; Spectrum Analysis; Spectrum Analysis, Raman; Spinal Column; Spine; Splicing; Stretching; Structure; Suppressor of Cytokine Signaling; Surface; System; System, LOINC Axis 4; Techniques; Techniques, Research; Testing; Time; Titrations; Translating; Translatings; Vertebral column; Vitamin B4; Work; X Ray Crystallographies; X-Radiation; X-Ray Crystallography; X-Rays; Xrays; analog; backbone; bacterial virus; base; biological signal transduction; catalyst; chemical reaction; chemical synthesis; conformation; conformational state; disease/disorder; emotional dependency; enzyme mechanism; experiment; experimental research; experimental study; functional group; gene function; genome mutation; group I ribozyme; heavy metal Pb; heavy metal lead; inorganic phosphate; insight; language translation; light scattering; mRNA; mRNA Precursor; membrane structure; new approaches; novel; novel approaches; novel strategies; novel strategy; phenylalanine-tRNA; phenylalanyl-tRNA; phosphodiester; phosphorothioate; premRNA; programs; protein synthesis; protonation; public health relevance; rRNA; research study; scaffold; scaffolding; shape analysis; shape description; signal recognition particle 7S RNA; snRNA; social role; tRNA(Phe); tRNA, phenylalanine-; tRNAPhe; three dimensional structure; tool; uRNA",Characterizing RNA-metal binding by Raman spectroscopy," PROJECT NARRATIVE Although RNA is a close relative of DNA it is far more versatile and plays many roles in the life of the cell. Thus, an understanding of the properties of RNA lies at the heart of our knowledge of the processes of life and to be able to control them when mal-function leads to disease states. The present proposal sets out to determine how RNA acts as a catalyst to bring about chemical reactions. The research involves following chemical reactions in very small RNA crystals using a laser light scattering technique.",81420,MSFA,Macromolecular Structure and Function A Study Section,,2,305648,
7760186,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM081554-03,,NIGMS:292050;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ATHENS,UNITED STATES,GENETICS,12,004315578,US,GA,306027411,UNIVERSITY OF GEORGIA (UGA),"KUSHNER, SIDNEY R.;",1863402;,5R01GM081554,03/15/2008,01/31/2012,"2',3'-exoribonuclease; 3' exonuclease; 3'-exoribonuclease; Accounting; Animal Model; Animal Models and Related Studies; Antibiotic Resistance; Bacteria; Bio-Informatics; Biochemical; Biochemistry; Bioinformatics; Biological; Cells; Chemistry, Biological; Collection; DNA Molecular Biology; DROSHA; Decay, mRNA; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E coli; Endoribonucleases; Enzymes; Escherichia coli; Eukaryota; Eukaryote; Exoribonuclease II; Exoribonucleases; Family; Gene Products, RNA; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Genome; Genomics; Intermediary Metabolism; Knowledge; METBL; Metabolic Processes; Metabolism; Modeling; Molecular; Molecular Biology; Mutation; Nuclear RNase III Drosha; Nucleases, RNA; Pancreatic RNase; Pancreatic ribonuclease; Pathway interactions; Polynucleotide Phosphorylase; Polyribonucleotide Nucleotidyltransferase; Polyribonucleotide[{..}]orthophosphate nucleotidyltransferase; Pre-tRNA; Prevalence; Process; Prokaryotae; Prokaryotic Cells; Proteins; RN3; RNA; RNA endonuclease; RNA, Non-Polyadenylated; RNA, Transfer, Precursors; RNASE3L; RNase; RNase A; RNase D; RNase E; RNase I; RNase II; RNase III; RNase O; RNase P; RNase Z; Reaction; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Ribonuclease A; Ribonuclease D; Ribonuclease Family Protein; Ribonuclease I; Ribonuclease III; Ribonuclease P; Ribonucleases; Ribonucleic Acid; Ribonucleic acids, transfer; Ribosomal RNA; Role; Series; System; System, LOINC Axis 4; Transfer RNA; Triplet Codon-Amino Acid Adaptor; Work; antibiotic resistant; design; designing; endonuclease; endoribonuclease; eukaryotida; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; mRNA Decay; model organism; mutant; p241; pathway; phosphodiesterase II; poly A specific exoribonuclease; prokaryote; rRNA; research study; ribonuclease E; ribonuclease II; social role; spleen exonuclease; spleen phosphodiesterase; tRNA; tRNA Precursor",Analysis of E. coli ribonucleases and RNA metabolism,,81554,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,3,292050,
7750525,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM081567-02,,NIGMS:393072;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PISCATAWAY,UNITED STATES,BIOCHEMISTRY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"INOUYE, MASAYORI ;",1866100;,5R01GM081567,01/01/2009,12/31/2012,"ATP-protein phosphotransferase; Affect; Anti-Sense RNA; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antisense RNA; Antitoxins; Apoptosis; Apoptosis Pathway; Bacteria; Bacterial Physiology; Bacterial Toxins; Biochemical; Biological; Biotechnology; Cell Death; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Cellular Regulation; Cessation of life; Chromosomes; Clinical; Complex; Death; Development; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug resistance; E coli; Endoribonucleases; Escherichia coli; Generalized Growth; Genes; Genetic; Genome; Goals; Growth; Habitats; Human; Human, General; Individual; Investigation; Laboratories; Lead; Life; M. tb; M. tuberculosis; M.tb; M.tuberculosis; Man (Taxonomy); Man, Modern; Medical; Messenger RNA; Microbial Biofilms; Miscellaneous Antibiotic; Modeling; Multi-Drug Resistance; Multidrug Resistance; Mycobacterium tuberculosis; Myxococcus xanthus; Nature; Operon; Outcomes Research; Pathogenicity; Pb element; Phase; Phenotype; Play; Production; Property; Property, LOINC Axis 2; Protein Kinase; Proteins; RNA endonuclease; RNA, Messenger; RNase; Relative; Relative (related person); Research; Research, Outcomes; Resistance; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Science; Stress; Subcellular Process; Suicide; System; System, LOINC Axis 4; Targeted Toxins; Time; Tissue Growth; Toxic effect; Toxicities; Toxin; Toxins, Targeted; Work; biofilm; cell growth; cell growth regulation; cellular targeting; drug resistant; endoribonuclease; fascinate; fatal attempt; fatal suicide; gene product; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; human tissue; hydroxyalkyl protein kinase; insight; intent to die; mRNA; multi-drug resistant; multidrug resistant; necrocytosis; new technology; novel; ontogeny; pathogen; pathogenic bacteria; phosphorylase b kinase kinase; public health relevance; resistance to Drug; resistant; resistant to Drug; social role; suicidal; suicidality; suicide gene; tool development",Deciphering of the Toxin-Antitoxin Systems in E. coli," Project Narrative Bacteria, including most of human pathogens, contain the TA (toxin-antitoxin) systems, which regulate their own cell growth and determine their own life and death. Research on the TA Systems has revealed their important roles in persisting drug-resistance and pathogenicity of human pathogens. The proposed search is to characterize all the TA systems in E. coli elucidating cellular targets of individual toxins, their mechanisms of action and their roles in bacterial physiology. The outcome from this research has a wide, important implication to our understanding of the basic principle of bacterial physiology, the roles of the TA systems in human pathogens and provides crucial insights into a novel technology to suppress cell growth of human pathogens or to lead them to death.",81567,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,2,393072,
7760597,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM081776-03,,NIGMS:247401;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHICAGO,UNITED STATES,,05,074438755,US,IL,606143394,CHILDREN'S MEMORIAL HOSPITAL (CHICAGO),"LI, HONGLIN ;",1898376;,5R01GM081776,04/01/2008,01/31/2013,"A-T protein; APO2 Ligand; APO2L; AT Mutated; AT mutated protein; ATM Protein; ATM Serine/Threonine Protein Kinase; ATM kinase; ATM protein kinase; Affect; Animals; Apo-2 Ligand; Apo-2L; Apoptosis; Apoptosis Pathway; Apoptotic; Ataxia Telangiectasia Mutated; Ataxia Telangiectasia Protein; Ataxia-Telangiectasia-Mutated protein kinase; Autoregulation; Behavior; Binding Proteins; CDC2 Protein Kinase; CDK1; Cancer Treatment; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Cycle Control; Cell Cycle Controller cdc2; Cell Cycle Progression; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death; Cell Death, Programmed; Cell Division Control Protein 2 Homolog; Cell Division Cycle; Cell Division Cycle 2; Cell Division Cycle 2 Protein; Cell Signaling; Cell division; Cell-Death Protease; Cells; Cessation of life; Checkpoint kinase 1; Chromatin; Chromosome Segregation; Cyclin-Dependent Kinase 1; Cytokinesis; Cytoplasmic Division; DNA; DNA Damage; DNA Damage Repair; DNA Injury; DNA Repair; DNA Replication; DNA Synthesis; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerase II; DNA Topoisomerases, Type II; DNA Type 2 Topoisomerase; DNA biosynthesis; Death; Defect; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Deoxyribonucleic Acid; Dephosphorylation; Development; Disease; Disorder; EC 2.7; EPEG; Ensure; Eposide; Etoposide; Event; Foundations; Genes, p53; Genetic Alteration; Genetic Change; Genetic Materials; Genetic defect; Genome Instability; Genome Stability; Genomic Instability; Genotoxins; Goals; HeLa; Hela Cells; Homeostasis; Hour; ICE-like protease; Intracellular Communication and Signaling; Kinases; Lastet; Lead; Ligand Binding Protein; Ligands; Light; M Phase; M phase (cell cycle); Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Materials, Genetic; Mediating; Mitosis; Mitosis Stage; Mitotic; Mutagens; Mutation; Normal Cell; Normal Tissue; Normal tissue morphology; Oncogenesis; P53; Pathogenesis; Pathway interactions; Pb element; Phase; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Photoradiation; Physical condensation; Physiological Homeostasis; Play; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dephosphorylation; Protein Phosphorylation; Proteins; Receptor Protein; Regulation; Reporting; Resistance; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stability, Genomic; System; System, LOINC Axis 4; TL2; TNF-Related Apoptosis Inducing Ligand TRAIL; TNF-related apoptosis-inducing ligand; TNFSF10; TNFSF10 Protein; TP53; TP53 gene; TRAIL Protein; TRP53; Testing; Topo II; Topoisomerase II; Transducers; Transmission; Transphosphorylases; Tumor Cell; Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor Protein p53 Gene; Unscheduled DNA Synthesis; Vepesid; Work; anticancer therapy; ataxia telangiectasia mutated protein; base; biological signal transduction; cancer cell; cancer therapy; caspase; cdc2 gene product; cdc2+ Protein; cdc25 Phosphatase; cdk1 Kinase; chk1 kinase; chk1 protein kinase; condensation; cystein protease; cystein proteinase; cysteine endopeptidase; daughter cell; disease/disorder; driving force; fighting; gene product; genome mutation; genotoxic agent; heavy metal Pb; heavy metal lead; human disease; in vitro Assay; inhibitor; inhibitor/antagonist; insight; irradiation; malignancy; necrocytosis; neoplasm/cancer; neoplastic cell; new approaches; new therapeutic target; novel; novel approaches; novel strategies; novel strategy; novel therapeutic intervention; overexpression; p34 (cdc2); p34 Protein Kinase; p34CDC2; pathway; phosphatase inhibitor; premature; public health relevance; receptor; repair; repaired; resistant; response; sensor; social role; therapeutic target; tissue culture; transmission process; tumorigenesis",Functional study of C53 protein as a novel regulator of checkpoint kinases,,81776,CSRS,Cellular Signaling and Regulatory Systems Study Section,,3,247401,
7760602,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM081878-03,,NIGMS:308880;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PISCATAWAY,UNITED STATES,GENETICS,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"LI, HONGHUA ;",1872195;,5R01GM081878,04/01/2008,01/31/2012,"18p; Alleles; Allelomorphs; Arm; Assay; Bioassay; Biologic Assays; Biological Assay; Biological Function; Biological Process; Chromosome 18 Proximal Arm; Chromosome 18 Short Arm; DNA Recombination; DNA recombination (naturally occurring); Data; Detection; Disease; Disease Association; Disorder; Ethnic group; Family; Generations; Genetic Condition; Genetic Diseases; Genetic Markers; Genetic Recombination; Genetic Structures; Genome; Genome, Human; Genotype; Hereditary Disease; Homo sapiens; Human; Human Genome; Human, General; Individual; Laboratories; Learning; Length; Location; Man (Taxonomy); Man, Modern; Maps; Meiosis; Meiotic Recombination; Methods; Molecular Disease; Pedigree; Phase; Polymorphism, Single Base; Process; Recombination; Recombination Fraction; Recombination, Genetic; Reporting; Resolution; SNP; SNPs; Sampling; Single Nucleotide Polymorphism; Site; Sperm; Spermatozoa; Spottings; Study Subject; System; System, LOINC Axis 4; Testing; Time; Upper arm; abstracting; base; density; design; designing; disease/disorder; genetic disorder; genetic pedigree; hereditary disorder; human disease; human male; meiotic; pedigree structure; sperm cell; success; technology development; zoosperm",Conservation of Meiotic Recombination Sites in the Human Genome,,81878,GCAT,"Genomics, Computational Biology and Technology Study Section",,3,308880,
7765576,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM082961-03,,NIGMS:234440;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,EAST LANSING,UNITED STATES,CHEMISTRY,08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"BORHAN, BABAK ;",6385425;,5R01GM082961,02/01/2008,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; Acetylene; Alcohols; Alkenes; Animal Welfare; Area; Assay; Azacyclopropanes; Azacyclopropanes, Saturated; Aziridines; Bibliography; Bioassay; Biologic Assays; Biological Assay; Cells; Chemical Class, Alcohol; Chemistry; Complex; Country; Cyclization; Dimethyleneimines; Ecological impact; Environment; Environmental Impact; Epoxides; Epoxy Compounds; Equipment; Ethics Committees, Research; Ethyleneimines; Ethylenimine Compound; Ethyne; Glycols; IACUC; IRBs; Impact, Environmental; Inorganic Sulfates; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Lead; Left; Libraries; Macropain; Macroxyproteinase; Metals; Method LOINC Axis 6; Methodology; Methods; Multicatalytic Proteinase; Names; Olefins; One Step; One-Step dentin bonding system; Pb element; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibitor; Proteosome; Pyrrolidines; Reaction; Research; Research Ethics Committees; Research Resources; Resources; Science of Chemistry; Secure; Structure; Sulfates; Sulfates, Inorganic; Sulfates, Unspecified or Sulfate Ion; System; System, LOINC Axis 4; Tumor Cell; Unspecified or Sulfate Ion Sulfates; Vertebrate Animals; Vertebrates; Work; abstracting; acetogenin; analog; base; cellular targeting; chiral molecule; cross-link; crosslink; design; designing; diene; expiration; functional group; heavy metal Pb; heavy metal lead; human subject; lactacystin; multicatalytic endopeptidase complex; neoplastic cell; novel; oxone; peroxymonosulfuric acid potassium salt; potassium peroxomonosulfate; potassium peroxymonosulfuric acid; programs; pyrrolidine; salinosporamide A; stereochemistry; sulfate; vertebrata; ylide",Regio and Stereoselective Reactions in Synthesis of Heterocycles,,82961,SBCB,Synthetic and Biological Chemistry B Study Section,,3,234440,
7796755,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM082962-02,,NIGMS:333816;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,PATHOLOGY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"REMICK, DANIEL G.;",1876217;,5R01GM082962,04/01/2009,01/31/2013,"4q Chemokine; Acute; Address; Animal Model; Animal Models and Related Studies; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Antibody Repertoire; Antigenic Determinants; Antiinflammatories; Antiinflammatory Agents; Assay; Attention; Bacteria; Bacterial Infections; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood Neutrophil; Blood Plasma; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Boston; C-X-C Chemokines; CXC Chemokines; Cessation of life; Chronic Phase; City of Boston; Clinical; Clinical Trials; Clinical Trials, Unspecified; Closure by Ligation; Coliform Bacilli; Complex; Cytokines, Chemotactic; DIF; Death; Disease; Disorder; Dose; EMAP; EMAP-2 protein, human; EMAPL2 protein, human; EML2 protein, human; Elements; Ensure; Enteric Bacteria; Enterobacteria; Enterobacteriaceae; Epitopes; Exhibits; Gamma Globulin, 19S; Glucocorticoids; Greater sac of peritoneum; Heterophil Granulocyte; Homologous Chemotactic Cytokines; Hour; HuEMAP-2 protein, human; Human; Human, General; IL-1; IL1; INFLM; IgM; Immune response; Immune system; Immunoglobulin M; Immunomodulators; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Effect; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Injury; Intercrines; Interleukin I; Interleukin-1; Investigation; Killings; Language; Ligation; Living Wills; Lung; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Methods; Mice; Miscellaneous Antibiotic; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Natural immunosuppression; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organ; Outcome; PERNUM; Patients; Peritoneal; Peritoneal Cavity; Peritoneum; Phagocytosis; Phase; Plasma; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Probability; Process; Puncture procedure; Punctures; Respiratory System, Lung; Reticuloendothelial System, Serum, Plasma; Risk; Role; SIS cytokines; Sepsis; Sepsis Syndrome; Serum, Plasma; Site; Staging; Suggestion; Syndrome; Systemic Inflammatory Response Syndrome; T Helper Factor; TNF; TNF A; TNF gene; TNFSF2; Technology; Therapeutic; Therapeutic Glucocorticoid; Time; Toxic effect; Toxicities; Trauma; Tumor Necrosis Factor Gene; Universities; Work; alpha-Chemokines; bacterial disease; biomarker; bloodstream infection; body system, allergic/immunologic; chemoattractant cytokine; chemokine; clinical investigation; clinical relevance; clinically relevant; cost efficient; cytokine; disease/disorder; echinoderm MT-associaated protein -like protein 70, human; echinoderm microtubule associated protein like 2 protein, human; effective therapy; experiment; experimental research; experimental study; host response; human EML2 protein; immunoresponse; immunosuppression; improved; inhibitor; inhibitor/antagonist; injured; innovate; innovation; innovative; insight; lymphocyte activating factor; model organism; neutralizing antibody; neutrophil; novel; organ system, allergic/immunologic; pathogen; prevent; preventing; public health relevance; pulmonary; research study; response; septic; social role; treatment strategy",Role of Cytokines in Sepsis and Trauma," Project Narrative Many patients still die from severe bacterial infections even when they are treated with the correct antibiotics. It is not clear why these patients die, or the best method to treat the patients. We will use an animal model to help us understand how bacteria kill patients and how to prevent this.",82962,SAT,"Surgery, Anesthesiology and Trauma Study Section",,2,333816,
7753891,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM083024-02,,NIGMS:267234;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAPEL HILL,UNITED STATES,BIOCHEMISTRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"COOK, JEANETTE GOWEN;",6872632;,5R01GM083024,01/01/2009,12/31/2013,"ATP-protein phosphotransferase; Address; Antioncogene Protein p53; Apoptosis; Apoptosis Pathway; CDK; Cancer cell line; Cancers; Cdk-activating kinase; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cellular Stress; Cellular Stress Response; Cellular Tumor Antigen P53; Checkpoint kinase 1; Chromatin; Classification; Complex; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; DNA; DNA Damage; DNA Injury; DNA Replication; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; DNA damage checkpoint; DNA damage checkpoint response; DNA damage response, signal transduction resulting in cell cycle arrest; DNA-Protein Interaction; Defect; Deoxyribonucleic Acid; Development; Diagnosis; Disease; Disorder; EC 2.7.2-; Ensure; Environment; Extracellular Signal-Regulated Kinases; First Gap Phase; G1 Arrest; G1 Block; G1 Phase; G1 period; Gap Phase 1; Genome; Genome Instability; Genome Stability; Genome, Human; Genomic Instability; Human; Human Genome; Human, General; Individual; Intracellular Communication and Signaling; Investigation; JNK; JNK1; JNK1A2; JNK21B1/2; Licensing; Licensing Factor; Link; M Phase; M phase (cell cycle); MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK8; MAPK8 gene; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Metastatic to; Methods; Mitogen-Activated Protein Kinases; Mitosis; Mitosis Stage; Modeling; Normal Cell; ORC protein; Oncogenesis; Oncoprotein p53; PRKM8; Pathway interactions; Phase; Phase Transition; Phosphoprotein P53; Phosphoprotein pp53; Phosphorylation; Proliferating; Protein Kinase; Protein Phosphorylation; Protein TP53; Protein p53; Proteins; Regulation; Replication Initiation; Replication Licensing; Risk; Role; SAPK1; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stability, Genomic; Stress; Systematics; TP53; Testing; Tumor Protein p53; biological signal transduction; cancer cell; cdk Proteins; chk1 kinase; chk1 protein kinase; controlled release; cyclin-dependent kinase-activating kinase; design; designing; disease/disorder; environmental change; extracellular; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; insight; malignancy; mitogen-activated protein kinase p38; neoplasm/cancer; novel; origin recognition complex; p38 MAP Kinase; p38 MAPK; p38 Protein Kinase; p38 SAPK; p53 Antigen; p53 Tumor Suppressor; pathway; phosphorylase b kinase kinase; prevent; preventing; protein protein interaction; public health relevance; response; social role; tumorigenesis",Replication licensing and cell cycle checkpoints," 7. Project Narrative:  Although it is clear that cancer cells proliferate inappropriately, it is still not fully understood how these cells differ from normal cells or what controls their progression to metastatic disease. Errors in the regulation of DNA replication are major contributors to cancer development, and this proposal is designed to gain new insight into the regulation of the first step in DNA replication, the localization of essential replication proteins to DNA. The specific focus is on the coordination of this initial step with the cellular responses to perturbations in the intracellular or extracellular environment.",83024,CSRS,Cellular Signaling and Regulatory Systems Study Section,,2,267234,
7759509,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM083050-03,,NIGMS:286405;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HOCHSTRASSER, MARK ;",1905686;,5R01GM083050,02/01/2008,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 26 S proteasome complex; 26S ATP-Dependent Protease; 26S ATP-Dependent Proteasome; 26S Proteasome Complex; 26S Proteosome; 26S protease; 26S proteasome; ATP Hydrolysis; ATP phosphohydrolase; ATPase; ATPase Domain; Address; Adenosine Triphosphatase; Adenosinetriphosphatase; Affect; Animal Welfare; Bibliography; Binding; Binding (Molecular Function); Biochemical; Biogenesis; Biosynthetic Proteins; Cancer Treatment; Cells; Complex; Core Particle; Country; E coli; Ecological impact; Environment; Environmental Impact; Equipment; Escherichia coli; Esteroproteases; Ethics Committees, Research; Eukaryota; Eukaryote; Eukaryotic Cell; Genetic; Goals; Housing; Human; Human, General; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Laboratories; Macropain; Macroxyproteinase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Methods; Modeling; Molecular; Molecular Interaction; Molecular Machines; Multicatalytic Proteinase; Names; Nucleosome Core; Nucleosome Core Particle; Origin of Life; Pathway interactions; Peptidases; Peptide Hydrolases; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosome; Proteases; Proteasome; Proteasome Endopeptidase Complex; Proteinases; Proteins; Proteolytic Enzymes; Proteosome; Recombinant Proteins; Research; Research Ethics Committees; Research Resources; Resources; Role; S cerevisiae; Saccharomyces cerevisiae; Shapes; Staging; Structure; System; System, LOINC Axis 4; Testing; Vertebrate Animals; Vertebrates; Yeast, Baker's; Yeast, Brewer's; Yeasts; abstracting; anticancer therapy; base; cancer therapy; eukaryotida; experiment; experimental research; experimental study; expiration; gene product; human subject; in vivo; interventional strategy; macromolecule; multicatalytic endopeptidase complex; mutant; new approaches; novel approaches; novel strategies; novel strategy; particle; pathway; programs; reconstitute; reconstitution; research study; social role; vertebrata",Function and Assembly of  Eukaryotic Proteasome,,83050,MBPP,Membrane Biology and Protein Processing Study Section,,3,286405,
7784464,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM083143-02,,NIGMS:295367;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MIAMI,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"HARHAJ, EDWARD W;",2103442;,5R01GM083143,04/01/2009,01/31/2013,"A20 protein; APF-1; ATGN; ATP-Dependent Proteolysis Factor 1; Adult T-Cell Leukemia-Lymphoma Virus I; Antigens; Autoimmune Status; Autoimmunity; Automobile Driving; Binding; Binding (Molecular Function); Cachectin; Cachectin-Tumor Necrosis Factor; Cachexia; Cancers; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Cellular Expansion; Cellular Growth; Chronic; Complex; Data; Defect; Deubiquitinating Enzyme; Development; Disease; Disorder; Drivings, Automobile; E3 Ligase; E3 Ubiquitin Ligase; EC 2.7; Embryo; Embryonic; Enzymes; Event; Exhibits; Family; Feedback; Fibroblasts; Future; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Goals; HMG-20; HTLV-1; HTLV-I; HTLV-I tax Gene Product; HTLV-I tax Protein; HTLV1; High Mobility Protein 20; Human T-Cell Leukemia Virus Type I tax Gene Product; Human T-Cell Leukemia Virus Type I tax Protein; Human T-Lymphotropic Virus, Type I; Human T-lymphotropic virus 1; Hybrids; IL-1; IL1; INFLM; Immunity; Immunoglobulin Enhancer-Binding Protein; Inflammation; Inflammatory; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; Investigation; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; Kinases; Knock-out; Knockout; Knockout Mice; LPS; Lead; Lipopolysaccharides; Lymphocyte-Stimulating Hormone; MAP Kinase 8; MAPK8 Mitogen-Activated Protein Kinase; MGC[{..}]3310; MGC[{..}]45012; Macrophage Cell Factor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mice; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Molecular; Molecular Interaction; Molecular Target; Multienzyme Complexes; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Oncogene Products; Oncogene Proteins; Oncogenesis; Oncoproteins; Pathologic; Pathway interactions; Pb element; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Play; Principal Investigator; Protein Phosphorylation; Proteins; Reagent; Recruitment Activity; Regulation; Research; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Specificity; Stimulus; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; T Helper Factor; T-Cell Leukemia Virus I, Human; TNF (unspecified); TNF Receptor Ligands; TNF Receptor-Associated Factor 6 Gene; TNF-alpha; TRAF2; TRAF2 gene; TRAF6; TRAF6 gene; TRAP3; Taxes; Trans-Activator Protein, HTLV-I; Transcription Factor NF-kB; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumor Suppressor Proteins; Ubiquitilation; Ubiquitin; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Up-Regulation; Up-Regulation (Physiology); Upregulation; Virus-HTLV-I; Yeasts; base; biological signal transduction; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cell growth; cytokine; disease/disorder; driving; enzyme complex; gene product; heavy metal Pb; heavy metal lead; human T cell lymphoma virus I; human T cell lymphoma virus type I; human T cell lymphotropic virus 1; human T cell lymphotropic virus type 1; human T lymphotropic virus I; human T-cell leukemia virus type 1; immunogen; inhibitor; inhibitor/antagonist; insight; intervention design; jun-NH2-Terminal Kinase; kappa B Enhancer Binding Protein; lymphocyte activating factor; malignancy; neoplasm/cancer; novel; nuclear factor kappa beta; pathway; protein complex; public health relevance; recruit; response; self recognition (immune); social role; stress-activated protein kinase 1; therapy design; transcription factor; treatment design; tumor necrosis factor (unspecified); tumor suppressor; tumorigenesis; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",Negative regulation of NF-kB and inflammation by TAX1BP1,"  Persistent activation of the transcription factor NF-kB is associated with autoimmunity, chronic inflammation and malignancy. We have found that the cellular proteins TAX1BP1 and Itch are pivotal negative regulators of persistent NF-kB activation by functioning as subunits of an A20 ubiquitin editing enzyme complex. This proposal will provide mechanistic insight into how TAX1BP1, Itch and A20 function together to inactivate key signaling molecules and restrict inflammatory signaling pathways.",83143,CSRS,Cellular Signaling and Regulatory Systems Study Section,,2,295367,
7752552,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM083303-03,,NIGMS:318830;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"LAHAV, GALIT ;",8481063;,5R01GM083303,03/01/2008,01/31/2013,"ATM Signaling Pathway; ATM pathway; ATM signaling; Affect; Age; Alleles; Allelomorphs; Anti-Estrogens; Apoptosis; Apoptosis Pathway; Behavior; Biological; Cancers; Cell Communication and Signaling; Cell Count; Cell Cycle; Cell Cycle Arrest; Cell Cycle Stage; Cell Death, Programmed; Cell Division Cycle; Cell Number; Cell Signaling; Cells; Commit; DNA Damage; DNA Damage Repair; DNA Double Strand Break; DNA Injury; DNA Repair; Data; Development; Diagnostic; Dose; Drugs; Estrogen Antagonists; Estrogenic Agents; Estrogenic Compounds; Estrogens; Feedback; Female; Frequencies (time pattern); Frequency; Gene Targeting; Genes; Genes, p53; Genetic Polymorphism; Goals; Gonadal Steroid Hormones; Height; Human; Human, General; Image; Individual; Intracellular Communication and Signaling; Knowledge; Life; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Masks; Math Models; Measurement; Measures; Medication; Methods; Modeling; Molecular; Outcome; P53; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic pulse; Polymorphism (Genetics); Polymorphism, Genetic; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postdoc; Postdoctoral Fellow; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Pulse; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation; Radiation Sensitivity; Radiation Tolerance; Radiosensitivity; Relative; Relative (related person); Reporting; Research Associate; Role; Sequence-Specific Posttranscriptional Gene Silencing; Series; Sex Hormones; Sex Steroid Hormones; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Targetings, Gene; Test Result; Testing; Therapeutic Estrogen; Time; Tumor Protein p53 Gene; Unscheduled DNA Synthesis; antiestrogen; antiestrogenic; biological signal transduction; cell imaging; cell type; cellular imaging; chemical genetics; computer based prediction; drug/agent; estrogen inhibitor; gene product; gonadal steroids; imaging; imaging modality; inhibitor; inhibitor/antagonist; insight; malignancy; mathematical model; mathematical modeling; neoplasm/cancer; novel; p53 Signaling Pathway; pathway; polymorphism; post-doc; post-doctoral; predictive modeling; programs; prototype; ray (radiation); repair; repaired; response; sex; sex steroid; social role",Dynamics of Signaling Pathways: Mechanism and Function,,83303,ZRG1,Special Emphasis Panel,,3,318830,
7753888,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM084103-02,,NIGMS:283091;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SALT LAKE CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"KADRMAS, JULIE L;",1956923;,5R01GM084103,01/01/2009,12/31/2013,"1D8 antigen; Actins; Address; Adhesions; Affect; Affinity; Antigenic Surface Determinant Protein OA3; Binding; Binding (Molecular Function); Binding Proteins; Biological Function; Biological Process; Body Tissues; CD47 Antigen; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer); CD47 Glycoprotein; CRR Domain; Cancers; Cell Adhesion; Cell Communication and Signaling; Cell Locomotion; Cell Mediated Immunology; Cell Migration; Cell Movement; Cell Nucleus; Cell Signaling; Cell membrane; Cell-Extracellular Matrix; Cell-Mediated Immunity; Cells; Cellular Adhesion; Cellular Immunity; Cellular Migration; Complement; Complement Proteins; Complex; Coupled; Coupling; Cultured Cells; Cysteine Rich Region; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Cytosol; Data; Defect; Deposit; Deposition; Disease; Disorder; Disseminated Malignant Neoplasm; Drosophila; Drosophila genus; EC 2.7; ECM; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Event; Exhibits; Export, Nuclear; Extracellular Matrix; Extracellular Matrix, Integrins; Fruit Fly, Drosophila; Gene Expression; Goals; Human; Human Pathology; Human, General; IAP-50 antigen; ILK; Immune response; Immunity, Cellular; Inflammatory; Inflammatory Response; Integrin-Associated Protein; Integrins; Intracellular Communication and Signaling; Kinases; LHX1; LHX1 gene; LIM Domain; LIM homeo box gene 1; LIM-1; LIM1; LIMS1; LIMS1 gene; LRR; LRR protein; Learning; Leucine-Rich Repeat; Leukocyte Surface Antigen CD47; Ligand Binding Protein; Location; MER6; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mediating; Membrane; Metastasis; Metastasize; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm; Metastatic Tumor; Molecular; Molecular Interaction; Molecular Mechanisms of Action; Motility; Motility, Cellular; Neoplasm Metastasis; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nuclear; Nuclear Export; Nuclear Translocation; Nucleus; OA3; OA3 antigen; OVTL3 protein, human; Oncogenic; PINCH; PINCH1; Phenotype; Phosphotransferases; Plasma Membrane; Play; Prevention strategy; Preventive strategy; Process; Protein Binding; Protein Binding Domain; Protein Binding Motif; Protein-Protein Interaction Domain; Proteins; RAS Family Oncogene; Receptor Protein; Recruitment Activity; Regulation; Regulatory Pathway; Regulatory Protein; Relative; Relative (related person); Research; Retrovirus Associated Sequence Oncogene; Right-Handed Beta-Alpha Superhelix; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Stimulus; Structure; Surface Antigen Identified by Monoclonal Antibody 1D8; Therapeutic Intervention; Tissues; Transphosphorylases; Tumor Cell Invasion; Tumor Cell Migration; Tumor Invasion; Work; Wound Healing; Wound Repair; biological signal transduction; cancer metastasis; cancer progression; cell motility; cohort; disease/disorder; experiment; experimental research; experimental study; fruit fly; gene product; genetic regulatory protein; host response; immunoresponse; insight; integrin-associated protein IAP, human; integrin-associated protein p50; integrin-linked kinase; interest; intervention therapy; leucine-rich repeat protein; malignancy; membrane structure; migration; mutant; neoplasm progression; neoplasm/cancer; neoplastic progression; neuronal; novel; null mutation; p59(ILK); plasmalemma; public health relevance; ras Oncogene; receptor; recruit; regulatory gene product; research study; scaffold; scaffolding; social role; therapeutic target; thrombospondin-1 receptor CD47; tissue repair; tumor; tumor progression",Mechanisms for regulation of cell adhesion and migration," Project Narrative Cell adhesion and migration are critical components of many biological processes including embryonic development, inflammatory and immune response, wound healing, and tumor invasion and metastasis. Cell adhesion and migration are controlled by an intricate network of regulatory circuits. This research will define new molecular mechanisms by which protein interactions regulate adhesion and migration, with the ultimate goal of identifying potential therapeutic targets for diseases arising from aberrant cell migration, such as the malignant progression of tumors.",84103,ICI,Intercellular Interactions,,2,283091,
7748008,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM084175-02,,NIGMS:294854;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"LI, RENHAO ;",6956659;,5R01GM084175,01/01/2009,12/31/2012,"Address; Affect; Amyloid A4 Protein Precursor; Amyloid Protein Precursor; Amyloid beta-Protein Precursor; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Blood leukocyte; C-terminal; CD62L Antigens; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cell Adhesion; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cell surface; Cells; Cellular Adhesion; Cleaved cell; Coagulation Factor IV; Complex; Cytokine Receptors; Cytoplasm; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Disease; Disorder; Dissociation; Environment; External Domain; Extracellular Domain; Factor IV; Fluorescence; Fluorescence Spectroscopy; GFAC; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hydrogen Oxide; Inflammatory; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; L-Selectin; LAM-1; LECAM-1; Lead; Leu-8 Antigen; Leukocyte Adhesion Molecule, LAM-1; Leukocytes; Lipids; Lymphocyte Adhesion Molecule 1; Marrow leukocyte; Mediating; Mel-14 Antigen; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; Mutation; Pb element; Peptides; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Plasma Membrane; Position; Positioning Attribute; Process; Proteins; Proteoglycan; Public Health; Receptors, Cytokine; Regulation; Relative; Relative (related person); Reticuloendothelial System, Leukocytes; Role; SEQ-AN; Sequence Analyses; Sequence Analysis; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solutions; Spectroscopy, Fluorescence; Surface; Surface Proteins; TM Domain; TQ1 Antigen; Testing; Thermodynamic; Thermodynamics; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; VESCL; Vesicle; Water; White Blood Cells; White Cell; adhesion receptor; amyloid precursor protein; aqueous; base; biological signal transduction; cleaved; conformation; conformational state; disease/disorder; extracellular; gene product; genome mutation; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; insight; membrane structure; new therapeutics; next generation therapeutics; novel therapeutics; peptide C; plasmalemma; polypeptide C; public health medicine (field); public health relevance; social role; stoichiometry; white blood cell; white blood corpuscle",Transmembrane Regulation of Ectodomain Shedding, PROJECT NARRATIVE Relevance to public health: Ectodomain shedding affects a variety of biologically important proteins. It malfunction often leads to diseases. Elucidating the mechanism underlying calmodulin regulation of L- selectin shedding will contribute to a better understanding of shedding regulation. Our findings may lead to novel therapeutic strategies.,84175,BBM,Biochemistry and Biophysics of Membranes Study Section,,2,294854,
7747970,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM084251-02,,NIGMS:308326;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,STONY BROOK,UNITED STATES,PHARMACOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"FROHMAN, MICHAEL A;",1883401;,5R01GM084251,01/01/2009,12/31/2012,"1,2-diacylglycerol; Acid, Phosphatidic; Acute; Agonist; Assay; Axon Terminals; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biology; Cell Communication and Signaling; Cell Signaling; Cells; Chemicals; Confocal Microscopy; D-Glucose; DAG; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diacylglycerols; Diglycerides; Disease; Disorder; Environment; Enzymes; FLR; Face; Failure (biologic function); Generations; Genetic Alteration; Genetic Change; Genetic defect; Glucose; Human; Human, General; Intracellular Communication and Signaling; Lead; Link; Lipids; Lipodystrophy; Location; MODY; Mammals, Mice; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Methods; Mice; Microscopy, Confocal; Mitochondria; Molecular; Morphology; Murine; Mus; Mutation; NIDDM; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Organelles; Outer Mitochondrial Membrane; Pb element; Phosphatases; Phosphatidic Acid; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiological; Presynaptic Terminals; Process; Production; Proteomics; Pyruvate Metabolism; Pyruvate Metabolism Pathway; Reader; Regulation; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stimulus; Surface; Synaptic Boutons; Synaptic Terminals; T2D; T2DM; Time; Transfection; Type 2 diabetes; Type II diabetes; Unpublished Works (PT); Unpublished Works [Publication Type]; adult onset diabetes; biological signal transduction; diabetes; diacylglycerol; diglyceride; disease/disorder; experiment; experimental research; experimental study; extracellular; facial; failure; genome mutation; heavy metal Pb; heavy metal lead; human disease; in vivo; insight; insulin signaling; ketosis resistant diabetes; lipin; lipine; maturity onset diabetes; mitochondrial; neurodegenerative illness; neuronal; novel; novel therapeutic intervention; public health relevance; research study; response; social role; tissue culture; tool development; unpublished works","Lipid signaling pathways regulating mitochondrial morphology, energetics, and mov"," Mitochondria are the ""powerhouse"" of the cell, generating energy from the chemical processing of glucose. Mitochondria function autonomously much of the time, but are also responsive to signals send from outside of the cell that direct them to increase their level of energy production, in part by increasing in size, and to move to sites within the cell where the energy demand is most acute. Failures in the ability of mitochondria to respond appropriate to these signals and generate adequate amounts of energy at the necessary location in the cell results in several types of human disease including Type II diabetes and neurodegenerative diseases. We are studying the molecular mechanisms that link the external signals to the mitochondrial responses, in hopes of obtaining insights that lead to the ability to pharmacologically manipulate them in the context of different disease settings.",84251,MBPP,Membrane Biology and Protein Processing Study Section,,2,308326,
7777769,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM084356-02,,NIGMS:325978;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BALTIMORE,UNITED STATES,BIOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"VAN DOREN, MARK B;",1933232;,5R01GM084356,03/01/2009,12/31/2012,"0-11 years old; Adhesion Molecule; Adhesions; Behavior; CAM 120/80; Cadherin-1; Cadherins; Cannot achieve a pregnancy; Cell Adhesion Molecules; Cell Body; Cell-Cell Adhesion; Child; Child Youth; Children (0-21); Chromatin; Data; Defect; Development; Difficulty conceiving; Disease; Disorder; Drosophila; Drosophila genus; E-Cadherin; Ensure; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Exhibits; Family; Fecundability; Fecundity; Female; Fertility; Flies; Fruit Fly, Drosophila; Gametes; Gene Expression; Genes; Genes, Regulator; Genital System, Female, Ovary; Genital System, Male, Testis; Germ Cells; Germ-Line Cells; Gonadal structure; Gonads; Human; Human, Child; Human, General; Infertility; Lead; Left; Liver Cell Adhesion Molecules; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Morphogenesis; Mother Cells; N-Cadherin; Ovary; Pb element; Primordium; Production; Progenitor Cells; Proteins; Recruitment Activity; Regulator Genes; Reproduction; Reproductive Cells; Role; Sex Cell; Sexual Development; Stem Cell Development; Stem cells; Syndrome; Testicles; Testing; Testis; Time; Transcriptional Regulatory Elements; Uvomorulin; Work; adult stem cell; base; cell adhesion protein; cell behavior; cell body (neuron); children; disease/disorder; fly; fruit fly; gene product; heavy metal Pb; heavy metal lead; infertile; initial cell; liver cell adhesion molecule; male; member; mutant; neural cell body; neuronal cell body; novel; public health relevance; recruit; regulatory gene; sex; sex determination; sex development; sex dimorphism; sexual cell; sexual dimorphism; social role; soma; stem cell niche; stem cell population; trans acting element; unable to bear children; youngster",Sexual development of the Drosophila gonad,"  Project Narrative  In this proposal, we will study how proper sexual development of the germ cells and somatic gonad combine to regulate germline stem cell formation and fertility. This is relevant to the many human syndromes that exhibit infertility and/or improper sexual development. Further, an understanding of how stem cell niches form and regulate their stem cell population is relevant for understanding how adult stem cells normally function and how their misregulation can result in disease.",84356,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,2,325978,
7760864,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM085796-03,,NIGMS:324546;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"UNDERHILL, DAVID M.;",1936404;,5R01GM085796,04/01/2008,01/31/2012,"ATGN; Actinin; Actins; Adjuvant; Affect; Agonist; Antigen Presentation; Antigen Presentation Pathway; Antigen Processing and Presentation; Antigens; Autophagocytosis; Binding; Binding (Molecular Function); Biological; Blood leukocyte; Cell Communication and Signaling; Cell Signaling; Cell-Death Protease; Cells; Cellular Matrix; Clinical; Complement Receptor; Coupled; Crohn's disease; Crohn's disorder; Cytokines, Chemotactic; Cytoplasmic Protein; Cytoskeletal System; Cytoskeleton; Dendritic Cells; Diathesis; Disease susceptibility; Eating; Enteritis, Granulomatous; Fc Receptor; FcR; Food Intake; Gene Proteins; Genes; Genetic Alteration; Genetic Change; Genetic defect; Genome; Homologous Chemotactic Cytokines; ICE-like protease; INFLM; Immune; Immune response; Immunity, Mucosal; Immunologic Receptors; Immunological Receptors; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Intercrines; Intracellular Communication and Signaling; Intracellular Membranes; Killings; Lead; Leukocytes; Link; Macrophage Activation; Marrow leukocyte; Mediating; Membrane; Microbe; Molecular; Molecular Interaction; Movement; Mucosal Immunity; Mutation; Nuclear; Organelles; Pathway interactions; Pb element; Peptide Domain; Phagocytosis; Phagolysosome; Phagosomes; Predisposition gene; Process; Production; Property; Property, LOINC Axis 2; Protein Binding Domain; Protein Binding Motif; Protein Domains; Protein Gene Products; Protein-Protein Interaction Domain; Proteins; Receptor Protein; Receptors, Immunologic; Recruitment Activity; Reticuloendothelial System, Leukocytes; Role; Route; SIS cytokines; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Susceptibility Gene; Tertiary Protein Structure; Veiled Cells; White Blood Cells; White Cell; abstracting; antibody receptor; autophagy; beta-glucan receptor; biological signal transduction; body movement; caspase; chemoattractant cytokine; chemokine; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; dectin 1; disease/disorder proneness/risk; eleocolitis; gene product; genome mutation; granulomatous enterocolitis; heavy metal Pb; heavy metal lead; host response; immune receptor; immunogen; immunoresponse; in vivo; intracellular skeleton; liability to disease; macrophage; mannose receptor; membrane structure; microbial; novel; particle; pathway; predisposing gene; protein protein interaction; receptor; recruit; regional enteritis; social role; white blood cell; white blood corpuscle",Phagosomal targeting of CARD proteins,,85796,III,Innate Immunity and Inflammation Study Section,,3,324546,
7751334,R01,GM,5,,01/01/2010,12/31/2010,PAR-07-249,5R01GM086238-02,,NIGMS:324772;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PITTSBURGH,UNITED STATES,BIOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"BAHAR, IVET ;",6910089;,5R01GM086238,01/01/2009,12/31/2012,"ATPase, Actin-Activated; Adenosine Triphosphatase, Myosin; Administrator; Algorithms; Allosteric Regulation; Analysis, Data; Area; Automobile Driving; Bears; Benchmarking; Best Practice Analysis; Bio-Informatics; Bioinformatics; Biological; Biological Function; Biological Process; Biology; Biomedical Computing; Biomedical Engineering; Biomedical Research; Body Tissues; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cereals; Chaperone; Chaperonin Family; Chemicals; Code; Coding System; Collaborations; Communication; Communities; Complement; Complement Proteins; Complex; Computational Biology; Computer Programs; Computer Simulation; Computer Software Development; Computer Software Engineering; Computer software; Computerized Models; Computing Methodologies; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Degradation Pathway; Degradative Pathway; Development; Disease; Disorder; Disorder of muscle, unspecified; Doctor of Philosophy; Documentation; Drivings, Automobile; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Elements; Engineering; Engineering, Software; Engineerings; Environment; Equation; Exhibits; Faculty; Family member; Fostering; Funding; Future; Gene Products, RNA; Generations; Genetic Medicine; Goals; Grain; Grant; Graph; Graphical interface; Hybrids; Imagery; Individual; Information Sciences; Infrastructure; Institutes; Institution; Internet; Intracellular Communication and Signaling; Investigation; Investigators; Knowledge; Lead; Learning, Machine; Length; Libraries; Licensing; Link; Literature; Machine Learning; Macromolecular Structure; Maps; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Mechanics; Mediating; Medical Device; Medical Research; Medication; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mission; Modeling; Models, Computer; Modification; Molecular; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Dynamics Simulation; Molecular Machines; Molecular Stereochemistry; Molecular Structure; Motion; Motor; Movement; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Newsletter; Non-linear Dynamic; Non-linear Dynamics; Nonlinear Dynamic; Nonlinear Dynamics; Operation; Operative Procedures; Operative Surgical Procedures; Organ System; Organ System, Cardiovascular; Organism; Outcome; Paper; Pathway interactions; Pattern; Pb element; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Physics; Physiologic; Physiological; Play; Polymers; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Dynamics; Proteins; Publishing; R01 Mechanism; R01 Program; RNA; RNA Folding; RNA, Non-Polyadenylated; RPG; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research, Medical; Researchers; Resolution; Ribonucleic Acid; Role; SEQ-AN; Scheme; Scientist; Sequence Analyses; Sequence Analysis; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; Site; Software; Software Engineering; Source; Statistical Mechanics; Structure; Students; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Technology; Testing; Time; Tissues; Training; Translating; Translatings; United States National Institutes of Health; Universities; Ursidae; Ursidae Family; Validation; Vascular, Heart; Visualization; WWW; Work; advanced simulation; analytical tool; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; biological systems; biomedical computation; biomedical scientist; body movement; body system; chaperone machinery; chaperonin; circulatory system; clinical data repository; clinical data warehouse; commercialization; computational framework; computational methodology; computational methods; computational modeling; computational models; computational simulation; computational tools; computer based models; computer framework; computer methods; computer program/software; computer science; computerized modeling; computerized simulation; computerized tools; conformation; conformational state; data modeling; data repository; design; designing; develop software; developing computer software; disease/disorder; dissemination research; driving; drug/agent; experiment; experimental research; experimental study; flexibility; gene product; graphic user interface; graphical user interface; heavy metal Pb; heavy metal lead; image visualization; improved; in silico; innovate; innovation; innovative; insight; interest; intermolecular interaction; kernel methods; language translation; living system; macromolecule; mathematical model; mathematical modeling; meetings; member; models and simulation; molecular dynamics; muscular disorder; myosin ATP phosphohydrolase (actin translocating); nano meter; nanometer; network models; neuromuscular; novel; open source; pathway; programs; protein folding; protein function; prototype; relational database; repository; research study; response; sharing data; simulation; social role; software development; statistical learning; structural genomics; support vector machine; surgery; theories; tool; user-friendly; virtual simulation; web; web site; world wide web",Structural Dynamics of Biomolecular Systems,,86238,ZRG1,Special Emphasis Panel,,2,324772,
7787501,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM086448-02,,NIGMS:452383;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BELMONT,UNITED STATES,,07,046514535,US,MA,02478,"MC LEAN HOSPITAL (BELMONT, MA)","RUDOLPH, UWE ;",8668680;,5R01GM086448,04/01/2009,01/31/2013,"1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-; 4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-; 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Amnesia; Amnesia-Memory Loss; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Anesthetics, General; Animal Model; Animal Models and Related Studies; Awareness; Awarenesses; Behavior; Behavioral; Behavioral Genetics; Benzodiazepine Compounds; Benzodiazepines; Brain region; CNS plasticity; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cornu Ammonis; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dendrites; Dentate Fascia; Dentate Gyrus; Development; Diazepam; Drug effect disorder; Drugs; Ethomidate; Etomidate; Event; Excitatory Synapse; Extinction; Extinction (Psychology); Fascia Dentata; Fear; Feedback; Fright; Funding; GABA-A Receptor; General Anesthesia; General anesthetic drugs; Generations; Genetic; Genetic Determinants of Behavior; Genetics, Behavioral; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Hydrogen Oxide; Incidence; Knock-out; Knockout; Laboratories; Lead; Learning; Long-Term Potentiation; Mammals, Mice; Measurement; Measures; Mediating; Medication; Memory; Methods; Methods and Techniques; Methods, Other; Mice; Midazolam; Modeling; Murine; Mus; Nerve Cells; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neuronal Plasticity; Neurons; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; PTSD; Pattern; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Play; Point Mutation; Position; Positioning Attribute; Post-Traumatic Stress Disorders; Primary Senile Degenerative Dementia; Process; Pyramidal Cells; Pyramidal neuron; Receptor Protein; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; Regulation; Role; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Structure of dentate gyrus; Study models; Subcellular Process; Synapses; Synaptic; Synaptic Transmission; Techniques; Testing; Time; Translating; Translatings; United States; Universities; Valium; Water; Wild Type Mouse; base; behavior genetics; behavioral extinction; conditioned fear; dementia of the Alzheimer type; dentate gyrus; drug action; drug/agent; experience; experiment; experimental research; experimental study; fear conditioning; granule cell; heavy metal Pb; heavy metal lead; hippocampal; hippocampal pyramidal neuron; hippocampal subregions; hypnotic; improved; information processing; language translation; learning extinction; memory encoding; memory recall; model organism; morris water maze; morris watermaze; neural plasticity; neuronal; neuroplasticity; new therapeutics; next generation therapeutics; novel; novel therapeutics; object recognition; primary degenerative dementia; public health relevance; receptor; research study; sedative; senile dementia of the Alzheimer type; social role; synapse inhibition; synaptic inhibition; traumatic neurosis",Regional actions of general anesthetics in inhibitory hippocampal networks," Relevance Intraoperative awareness during general anesthesia has been suggested to occur with an incidence of 0.13% translating to approximately 26,000 cases per year in the United States. The proposal is directed at elucidating the mechanism of action of general anesthetics on learning and memory and the hippocampal inhibitory networks mediating this effect and is expected to lead to novel therapeutic strategies for the development of amnestic drugs to be used in general anesthesia, for the treatment of posttraumatic stress disorder, and potentially also for the development of memory-enhancing drugs e.g. for the treatment of Alzheimer's disease.",86448,ZRG1,Special Emphasis Panel,,2,452383,
7747963,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM086456-02,,NIGMS:250034;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ROCHESTER,UNITED STATES,GENETICS,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"PORTMAN, DOUGLAS S;",7947400;,5R01GM086456,01/01/2009,12/31/2012,"Address; Affect; Affective Disorders; Afferent Neurons; Animals; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Binding Sites; Biological; Blood Coagulation Factor IV; C elegans; C.elegans; Ca++ element; Caenorhabditis elegans; Calcium; Candidate Disease Gene; Candidate Gene; Cells; Cellular Regulation; Characteristics; Chemotherapy-Hormones/Steroids; Coagulation Factor IV; Combining Site; Consensus; Coupled; Development; Drosophila; Drosophila genus; Endocrine Gland Secretion; Factor IV; Family; Fruit Fly, Drosophila; Gender Bias; Gene Expression; Gene Family; Genes; Genetic; Hormones; Human; Human, General; Kanner's Syndrome; Light; Link; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mental Health; Mental Hygiene; Modeling; Modification; Molecular; Molecular Genetic; Molecular Genetics; Mood Disorders; NRVS-SYS; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System Diseases; Nervous System Physiology; Nervous system structure; Neural Cell; Neural Development; Neurobiology; Neurocyte; Neurologic; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurologic function; Neurological; Neurological Disorders; Neurological function; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology - biologic function; Olfaction; Olfactions; Pattern; Photoradiation; Predisposition; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychological Health; Reactive Site; Regulation; Regulatory Pathway; Research; Resolution; Role; Sensory Cell Afferent Neuron; Sex Bias; Sex Characteristics; Sex Differences; Sexism; Sexual Development; Shapes; Smell; Smell Perception; Soil; Stimulus; Susceptibility; Syndrome; Therapeutic Hormone; Work; cell growth regulation; cell type; chronic pain; chronic painful condition; combinatorial; design; designing; fruit fly; gender difference; genome-wide; innovate; innovation; innovative; insight; interest; male; member; nervous system disorder; nervous system function; neural; neural control; neural function; neural mechanism; neural regulation; neurobiological; neurodevelopment; neurological disease; neuromechanism; neuronal; neuroregulation; preference; programs; public health relevance; relating to nervous system; response; roundworm; sex; sex development; sexual dimorphism (noncellular); social role; synapse function; synaptic function; transcription factor",Genetic control of sex differences in the nervous system,,86456,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,2,250034,
7749048,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM086560-02,,NIGMS:310860;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DALLAS,UNITED STATES,PHARMACOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"MUMBY, MARC C.;",1887187;,5R01GM086560,01/01/2009,12/31/2012,"ATP-protein phosphotransferase; Affect; Affinity; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Back; Binding Sites; Blood Coagulation Factor IV; CDT1; Ca++ element; Calcium; Calcium Binding; Calcium Ion Signaling; Calcium Signaling; Cancers; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Proteins; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Division Cycle Proteins; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell division; Cell-Cycle Regulatory Proteins; Cells; Cellular Proliferation; Chromatin; Coagulation Factor IV; Combining Site; Complex; DNA Replication; DNA Replication Factor; DNA Replication Initiation; DNA Synthesis; DNA biosynthesis; Dephosphorylation; Dorsum; Double Parked, Drosophila, Homolog of; Ensure; Factor IV; Gene Expression; Goals; HCDT1; Intracellular Communication and Signaling; Malignant Neoplasms; Malignant Tumor; Mammalian Cell; Mediating; Molecular; P105-RB; PP110; Pathway interactions; Phase; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pre-Replication Complex; Protein Dephosphorylation; Protein Kinase; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Quelling; RB1; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rb Gene Product; Rb Protein; Rb1 Gene Product; Reactive Site; Regulation; Replication Initiation; Resistance; Retinoblastoma Associated Protein; Retinoblastoma Protein; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Staging; Structure; Testing; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; cdc Proteins; dimer; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; malignancy; neoplasm/cancer; novel; pRB; pathway; phosphorylase b kinase kinase; pre-RC; public health relevance; research study; resistant; social role",Cell cycle regulation by protein phosphatase 2A, Inappropriate cell proliferation occurs in many pathological settings including cancer and atherosclerosis. The mammalian cell cycle is regulated by a network of signaling pathways that ensure cell division occurs with high fidelity and only under appropriate conditions. Recent evidence has shown that a calcium-regulated subunit of of a cellular protein phosphatase (PP2A) is involved in dephosphorylation of proteins that are critical for regulating the cell cycle. The goals of this proposal are to test the hypothesis that PP2A mediates calcium-dependent regulation of the cell cycle through actions on these proteins.,86560,MIST,Molecular and Integrative Signal Transduction Study Section,,2,310860,
7763157,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM086617-02,,NIGMS:245938;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,GAINESVILLE,UNITED STATES,,03,134136394,US,FL,32604,FOUNDATION FOR APPLIED MOLECULAR EVOLUTN,"LYONS, THOMAS J;",1903616;,5R01GM086617,02/01/2009,01/31/2014,"ATF; Accounting; Address; Adverse effects; Affect; Agonist; Anti-Progestin; Anti-progesterones; Assay; Barbiturates; Behavior; Binding; Binding (Molecular Function); Bioassay; Bioavailability; Biochemical; Biochemistry; Biologic Assays; Biologic Availability; Biological; Biological Assay; Biological Availability; Biological Models; Biology; Cancer Treatment; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chemicals; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Classification; Contraception; Contraceptive methods; Corlutina; Corluvite; Corpus Luteum Hormone; Cyclogest; Cytoplasmic Membrane; Delta4-pregnene-3,20-dione; Drug Prescribing; Drug Prescriptions; Drugs; Elements; Emergencies; Emergency Situation; Endocrine Gland Secretion; Endometriosis; Endometriosis, site unspecified; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Family; Fertility Control; Fishes; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gene Expression; Gene Targeting; Gene Transcription; Genetic Transcription; Genomics; Gestagenic Agents; Gestagens; Gestation; Gestiron; Gestone; Goals; Half-Life; Half-Lifes; Homologous Protein; Hormone Receptor; Hormone Replacement Rx; Hormone replacement therapy; Hormones; Human; Human Figure; Human body; Human, General; Individual; Inhibition of Fertilization; Integral Membrane Protein; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Intracellular Signaling Proteins; Intrinsic Membrane Protein; Investigators; Lead; Libraries; Ligand Binding; Ligands; Light; Lipo-Lutin; Luteohormone; Lutocyclin; Lutocylin M; Lutogyl; Lutromone; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane; Model System; Modeling; Models, Biologic; Molecular Interaction; Moods; Names; Nuclear; Organism; Paint; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacology; Photoradiation; Physiologic; Physiologic Availability; Physiological; Physiology; Plasma Membrane; Play; Pregn-4-ene-3,20-dione; Pregnancy; Pregnenedione; Prescriptions, Drug; Progestagenic Agents; Progestasert; Progestational Agents; Progestational Compounds; Progestational Hormones; Progesterone; Progesterone Agents; Progesterone Receptors; Progesterone-Binding Globulin; Progesterone-Binding Protein; Progestins; Progestogel; Progestogens; Progestol; Progeston; Prolidon; Proluton; Property; Property, LOINC Axis 2; Protein Binding; Protein Homolog; ProteinHomolog; Proteins; Public Health; RNA Expression; Receptor Protein; Receptors, Progesterone; Receptors, Progestin; Reproduction; Research Personnel; Researchers; Role; S cerevisiae; Saccharomyces cerevisiae; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Proteins, Intracellular; Sphingolipids; Steroid Compound; Steroids; Structure; Structure-Activity Relationship; Study models; Syngesterone; System; System, LOINC Axis 4; Systematics; Targetings, Gene; Testing; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Therapeutic Progestin; Therapeutic Steroid Hormone; Transcription; Transcription, Genetic; Transmembrane Protein; Transprogestin; Treatment Side Effects; Uncertainty; Utrogestan; Vertebrate Animals; Vertebrates; Yeast, Baker's; Yeast, Brewer's; Yeasts; activating transcription factor; anticancer therapy; barbiturate; barbituric acid salt; base; bioavailability of drug; biological signal transduction; biological systems; birth control; cancer therapy; chemical structure function; design; designing; doubt; drug/agent; endometriosis; experiment; experimental research; experimental study; extracellular; gene product; heavy metal Pb; heavy metal lead; in vivo; living system; membrane structure; neurosteroids; non-genomic; nongenomic; novel; pathway; plasmalemma; progesterone receptor; public health medicine (field); receptor; receptor function; research study; response; second messenger; side effect; social role; steroid hormone; structure function relationship; therapy adverse effect; treatment adverse effect; vertebrata",Biochemical and pharmacological studies of human membrane progesterone receptors," Project Narrative The steroid hormone, progesterone, and molecules that modulate its effects are of critical pharmaceutical and environmental importance. We have established a system through which we can investigate how such molecules affect a new family of hormone receptors that is largely unstudied. The studies outlined in this proposal will significantly expand our understanding of how human cells sense and respond to steroid hormones.",86617,MIST,Molecular and Integrative Signal Transduction Study Section,,2,245938,
7749041,R01,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R01GM086808-02,,NIGMS:273317;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MIAMI,UNITED STATES,PHYSIOLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"MOY, VINCENT T;",1940298;,5R01GM086808,01/01/2009,12/31/2012,"1H-Pyrrole-2,5-dione, 1-ethyl-; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Action Potentials; Address; Aminalon; Aminalone; Arts; Atomic Force Microscope; Atomic Force Microscopy; Axon Terminals; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biological Neural Networks; Blood Coagulation Factor IV; Butanoic acid, 4-amino-; Ca++ element; Calcium; Calcium Binding; Calcium Channel; Calcium Channel Antagonist Receptor; Catecholamines; Cell Communication and Signaling; Cell Signaling; Cell membrane; Charge; Chemical Synapse; Coagulation Factor IV; Collaborations; Complex; Coupled; Coupling; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Tail; Docking; Ethylmaleimide; Exocytosis; Factor IV; Force Microscopy; GABA; Glutamates; Hydration; Hydration status; Individual; Intracellular Communication and Signaling; Ion Channels, Calcium; L-Glutamate; Laboratories; Leucine Zippers; Ligand Binding Protein; Lipid Bilayers; Measurement; Measures; Mechanics; Mediating; Membrane; Membrane Fusion; Methods; Methods and Techniques; Methods, Other; Microscopy, Atomic Force; Molecular; Molecular Interaction; N ethylmaleimide; N-Ethylmaleimide; NEM; NSF attachment protein receptor; Nerve Cells; Nerve Endings, Presynaptic; Nerve Transmitter Substances; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurotransmitters; Phosphatides; Phospholipids; Plasma Membrane; Play; Presynaptic Terminals; Procedures; Process; Property; Property, LOINC Axis 2; Proteins; Reagent; Receptor Protein; Receptors, Calcium Channel Blocker; Research; Role; SNAP receptor; SNARE; Scanning Force Microscopy; Secretory Granules; Secretory Vesicles; Signal Transduction; Signal Transduction Systems; Signaling; Surface; Sympathins; Synaptic Boutons; Synaptic Cleft; Synaptic Terminals; TM Domain; Techniques; Testing; Therapeutic; Transmembrane Domain; Transmembrane Region; Transmission; Universities; VDCC; VESCL; Vesicle; Voltage-Dependent Calcium Channels; Wisconsin; Work; biological signal transduction; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; gene product; lipid bilayer membrane; membrane structure; nervous system disorder; neural network; neurological disease; neuronal; neurotransmitter release; plasmalemma; prevent; preventing; public health relevance; receptor; reconstitute; reconstitution; research study; response; single molecule; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; stem; synaptotagmin; syntaxin; syt (synaptotagmin); t-SNARE; target SNARE proteins; target membrane SNARE proteins; transmission process",AFM studies of SNARE-mediated membrane fusion, Project Narrative The proposed research applies biophysical methods toward elucidating the underlying mechanism of Ca2+ triggered exocytosis of neurotransmitters during signal transmission at chemical synapses of neural networks. The fundamental problem to be addressed is how do neurons regulate the fusion of vesicles with the plasma membrane. A detailed molecular understanding of Ca2+ triggered exocytosis is important because components of vesicle machinery are potential targets of many therapeutic reagents for a plethora of neurological disorders.  ,86808,BBM,Biochemistry and Biophysics of Membranes Study Section,,2,273317,
7782696,R01,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R01GM087016-02,,NIGMS:293294;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,WEST LAFAYETTE,UNITED STATES,CHEMISTRY,04,072051394,US,IN,479072114,PURDUE UNIVERSITY WEST LAFAYETTE,"THOMPSON, DAVID H;",1862409;,5R01GM087016,04/01/2009,01/31/2013,"Acids; Adsorption; Assay; Behavior; Bioassay; Bioavailability; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Biology; Biophysics; Body Tissues; Cell Membrane Lipids; Cell division; Cells; Cellular biology; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Complex; Confocal Microscopy; Cytofluorometry, Flow; Cytoplasm; Defect; Development; Dimensions; Drug Formulations; Electromagnetic, Laser; Endosomes; Environment; Equilibrium; Exposure to; Family; Fertility/Fertilization; Fertilization; Film; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Formulation; Formulations, Drug; Goals; HPLC; High Pressure Liquid Chromatography; Hydrogen Bonding; Kinetic; Kinetics; Laboratories; Lasers; Libraries; Lipids; Macrogols; Masks; Mediating; Membrane; Membrane Fusion; Membrane Lipids; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microfluorometry, Flow; Microscopy, Confocal; Molecular; Molecular Dynamics Simulation; Monitor; Nature; Neural Transmission; Non-Viral Vector; Nucleic Acids; PEG; Peptide Domain; Peptides; Phase; Phase Transition; Physiologic Availability; Play; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polyoxyethylenes; Process; Protein Domains; Radiation, Laser; Receptosomes; Research; Rod; Rod Photoreceptors; Rods (Eye); Rods (Retina); Role; Shapes; Synaptic Transmission; Synthesis Chemistry; Synthetic Chemistry; System; System, LOINC Axis 4; Techniques; Temperature; Tertiary Protein Structure; Testing; Therapeutic; Tissues; VESCL; Vesicle; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; balance; balance function; base; bioavailability of drug; cell biology; design; designing; divinyl ether; divinyl oxide; experiment; experimental research; experimental study; flow cytophotometry; folate carrier; folate receptor; folate-binding protein; folate-methotrexate transporter; folic acid binding protein; folic acid receptor; improved; membrane model; membrane structure; methotrexate-binding protein; molecular dynamics; monolayer; nano particle; nanoparticle; novel; performance tests; plasmid DNA; polycation; public health relevance; receptor mediated endocytosis; research study; rod cell; social role; theories; trafficking; transgene expression; vinyl ether; virus protein",Development of Bioresponsive Lipids for Intracellular Delivery," The primary objective of the proposed research is to synthesize new compounds that can be used to control lipid-mediated membrane fusion. An interdisciplinary project is described that will expand the range of materials available for accelerating this fundamentally important process. The proposed materials will be incorporated within guest membrane vesicles as masked, nonfusogenic compounds that will become fusogenic upon exposure to acidic or oxidative environments--a triggering process that is conceptually similar to pH-induced viral protein-based membrane fusion within acidic endosomes. The most efficient fusogens will be assayed, using flow cytometry and laser confocal microscopy techniques, for their ability to effect cytoplasmic release of plasmid DNA cargo in cells targeted to internalize these carriers via receptor mediated endocytosis.",87016,ZRG1,Special Emphasis Panel,,2,293294,
7761196,R01,HD,5,,02/01/2010,01/31/2011,PA-07-027,5R01HD041527-10,,NICHD:610640;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"GOODMAN, ELIZABETH ;",7890987;,5R01HD041527,02/01/2002,01/31/2012,"12-20 years old; 21+ years old; Active Follow-up; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Animal Welfare; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bibliography; Blood Circulation; Bloodstream; Brain; Cachectin; Cachectin-Tumor Necrosis Factor; Causality; Cessation of life; Childhood; Circulation; Cognition; Cohort Studies; Concurrent Studies; Country; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Collection; Death; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Differentiation Factor, B-Cell; Disadvantaged; Disease Frequency Surveys; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equation; Equipment; Ethics Committees, Research; Ethnic Origin; Ethnicity; Ethnicity aspects; Etiology; Factors, Psychological; Family; Fostering; Goals; Grant; HDL Cholesterol; HPGF; Health; Hepatocyte-Stimulating Factor; High Density Lipoprotein Cholesterol; Human, Adult; Hybridoma Growth Factor; IACUC; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; IRBs; Impact, Environmental; Individual; Inflammation; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Insulin Resistance; Interleukin 6 (Interferon, Beta 2); Interleukin-6; International; Intervention; Intervention Strategies; Life Cycle; Life Cycle Stages; Link; Lipoproteins, HDL Cholesterol; MGI-2; MODY; Maturity-Onset Diabetes Mellitus; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Metabolic syndrome; Minority; Modeling; Morbidity; Morbidity - disease rate; Myeloid Differentiation-Inducing Protein; NIDDM; Nervous System, Brain; Neuroendocrine; Neuroendocrine System; Neurogenic Inflammation; Neurosecretory Systems; Non-Hispanic; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Paper; Pathway interactions; Perception; Physiologic; Physiological; Plasmacytoma Growth Factor; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Prospective Studies; Psychological Factors; Race; Racial Group; Research; Research Design; Research Ethics Committees; Research Resources; Resistance; Resources; Role; SUBGP; Schools; Shapes; Social status; Societies; Socio-economic status; Socioeconomic Status; Status, Socioeconomic; Stocks, Racial; Stress; Study Type; Subgroup; T2D; T2DM; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Time; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Type 2 diabetes; Type II diabetes; Vertebrate Animals; Vertebrates; Work; Youth; Youth 10-21; abstracting; adiposity; adolescence (12-20); adult human (21+); adult onset diabetes; alpha-Lipoprotein Cholesterol; base; biomarker; cohort; corpulence; corpulency; corpulentia; cytokine; design; designing; diabetes; disease causation; disease etiology; disease/disorder etiology; disorder etiology; emerging adult; experience; expiration; follow-up; health disparities; health disparity; human subject; insulin resistant; insulin signaling; interferon beta 2; interventional strategy; juvenile; juvenile human; ketosis resistant diabetes; life course; low socioeconomic status; maturity onset diabetes; obese; obese people; obese person; obese population; obesity risk; pathway; pediatric; programs; prospective; psychologic; psychological; resistant; response; social; social role; study design; teenage; trait; tumor necrosis factor (unspecified); vertebrata",Understanding Social Status' Impact on Adolescent Health,,41527,KNOD,"Kidney, Nutrition, Obesity and Diabetes Study Section",,10,610640,
7749527,R01,HD,5,,02/01/2010,08/31/2010,,5R01HD043869-07,,NICHD:146923;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BOSTON,UNITED STATES,,08,076593722,US,MA,021155737,CHILDREN'S HOSPITAL BOSTON,"GORDON, CATHERINE M;",1939231;,5R01HD043869,04/01/2004,08/31/2010,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 3beta-Hydroxyandrost-5-en-17-one; 5-Androsten-3-beta-hydroxy-17-one; ADRGND; Address; Adolescent; Adolescent Youth; Adrenal Glands; Adrenals; Aeroseb-HC; Aged 65 and Over; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Androst-5-en-17-one, 3-hydroxy-, (3beta)-; Androstenolone; Anorexia Nervosa; Area; Blood Coagulation Factor IV; Blood Serum; Bone; Bone Density; Bone Formation; Bone Mineral Density; Bone Resorption; Bone and Bones; Bones and Bone Tissue; Ca++ element; Calcium; Cetacort; Coagulation Factor IV; Complication; Corlutina; Corluvite; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Coxa; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Cyclogest; DHEA; Data; Dehydroisoandrosterone; Delta4-androsten-17beta-ol-3-one; Dermacort; Disease Frequency Surveys; Eldecort; Elderly; Elderly, over 65; Estrogen Replacements; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exercise; Exercise, Physical; Exhibits; Factor IV; Fracture; Gestagenic Agents; Gestagens; Gestiron; Gestone; Goals; Gonadal Steroid Hormones; Hip; Hip region structure; Hormonal; Hydrocortisone; Hydrocortone; Hytone; IGF-1; IGF-I; IGF-I-SmC; IGF1; Injection of therapeutic agent; Injections; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Investigators; Lipo-Lutin; Luteohormone; Lutocyclin; Lutocylin M; Lutogyl; Lutromone; Measurement; Measures; Mechanics; Mediating; Nervosas, Anorexia; Nutracort; Oral; Osteoclastic Bone Loss; Osteogenesis; Osteoporosis; PBO; Patients; Placebos; Prasterone; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Proctocort; Progestagenic Agents; Progestasert; Progestational Agents; Progestational Compounds; Progestational Hormones; Progesterone Agents; Progestins; Progestogel; Progestogens; Progestol; Progeston; Programs (PT); Programs [Publication Type]; Prolidon; Proluton; Randomized Controlled Trials; Regimen; Replacement Therapy; Research; Research Personnel; Researchers; Risk; Role; Serum; Sex Hormones; Sex Steroid Hormones; Sham Treatment; Somatomedin C; Structure; Syngesterone; System; System, LOINC Axis 4; Teen; Teenagers; Teens; Testing; Testosterone; Therapeutic; Therapeutic Androgen; Therapeutic Dehydroepiandrosterone; Therapeutic Estrogen; Therapeutic Hydrocortisone; Therapeutic Progestin; Therapeutic Testosterone; Trans-Testosterone; Utrogestan; VIT D; Vitamin D; Weight; Weight Gain; Weight Increase; Woman; advanced age; body weight gain; body weight increase; bone; bone fracture; bone loss; bone mass; bone strength; bone turnover; critical period; dehydroepiandrosterone; density; elders; geriatric; gonadal steroids; indexing; juvenile; juvenile human; late life; later life; new approaches; novel approaches; novel strategies; novel strategy; older adult; older person; programs; randomized controlled study; response; senior citizen; sex steroid; sham therapy; skeletal; social role; standard measure; suprarenal gland; teen years; urinary; wt gain",Effects of Adrenal and Gonadal HR in Young Women with AN,,43869,SBSR,Skeletal Biology Structure and Regeneration Study Section,,7,146923,
7730844,R01,HD,5,,12/01/2009,11/30/2010,PA-07-070,5R01HD046236-07,,NICHD:581369;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW YORK,UNITED STATES,BIOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"GUNSALUS, KRISTIN C;PIANO, FABIO  (contact);",1904599;8165394 (contact);,5R01HD046236,12/01/2003,11/30/2013,"Address; Affect; Alleles; Allelomorphs; Analysis, Data; Architecture; Archives; Area; Assay; Award; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Biology; Budgets; Buffers; C elegans; C. elegans genome; C.elegans; Caenorhabditis elegans; Cell Polarity; Cell division; Chromosome Mapping; Code; Coding System; Complex; Data; Data Analyses; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Developmental Process; Disease; Disorder; Educational process of instructing; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Engineering / Architecture; Enhancers; Ensure; Event; Evolution; Fertility/Fertilization; Fertilization; Funding; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Models; Genetic analyses; Genetic screening method; Genetics, Gene Mapping; Genome; Genome, Human; Goals; Human; Human Genome; Human, General; Image; Kinetochores; Laboratories; Lead; Link; Linkage Mapping; M Phase; M phase (cell cycle); Man (Taxonomy); Man, Modern; Maps; Meiosis; Mitosis; Mitosis Stage; Modeling; Models, Genetic; Molecular; Molecular Genetic; Molecular Genetics; Nuclear Envelope; Nuclear Membrane; Organism; Outcome; Pathway interactions; Pattern; Pb element; Phenotype; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Program Development; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Resolution; Role; Sequence-Specific Posttranscriptional Gene Silencing; Staging; System; System, LOINC Axis 4; Teaching; Testing; Time; Work; Yeasts; base; cellular polarity; clinical data repository; clinical data warehouse; combinatorial; data integration; data repository; disease/disorder; experience; functional genomics; gene interaction; gene product; genetic analysis; genetic mapping; genetic testing; genome sequencing; genome, C elegans; genome, C. elegans; genome, C.elegans; genome, Caenorhabditis elegans; genome-wide; heavy metal Pb; heavy metal lead; human disease; imaging; in vivo; insight; living system; meiotic; pathway; programs; protein protein interaction; relational database; scaffold; scaffolding; social role; tool",A Systematic RNAi-based Map of C. elegans Embryogenesis,,46236,GCAT,"Genomics, Computational Biology and Technology Study Section",,7,581369,
7761218,R01,HD,5,,02/01/2010,01/31/2011,,5R01HD049767-04,,NICHD:210989;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,SEATTLE,UNITED STATES,NONE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"HERRENKOHL, TODD I;",2122932;,5R01HD049767,04/01/2007,01/31/2011,"0-11 years old; 12-20 years old; 21+ years old; AOD use; Adolescence; Adolescent; Adolescent Development; Adolescent Youth; Adult; Age; Age-Years; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; Attention; Behavior; Child; Child Abuse; Child Abuse and Neglect; Child Welfare; Child Youth; Childhood; Childhood Abuse; Childhood maltreatment; Children (0-21); Collaborations; Communities; Conflict; Conflict (Psychology); Crime; Data; Data Collection; Development; Domestic Violence; Drugs; Economic Income; Economical Income; Effects, Longterm; Emotional; Employment; Equilibrium; EtOH drinking; Exposure to; Family; Family Violence; Funding; Gender; Housing; Human, Adult; Human, Child; Income; Individual; Interpersonal Interaction; Interpersonal Relations; Investments; Life; Link; Long-Term Effects; Longitudinal Studies; Medication; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; Neighborhoods; Nursery Schools; Outcome; Parent-Child Relations; Parent-Child Relationship; Parenting; Parenting behavior; Parents; Participant; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Abuse of Child; Physical child abuse; Policies; Poverty; Problem Solving; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychological abuse; Qualifying; Records; Recovery; Research; Research Resources; Resources; Risk Factors; Risk-Taking; Sampling; School-Age Population; Schools, Nursery; Sex Characteristics; Sex Differences; Sexual abuse; Site; Social Problems; Social support; Source; Staging; Survey Instrument; Surveys; Time; Unemployment; Unspecified Mental Disorder; Violence; Violence, Family; abuse mental; abuse neglect; adolescence (12-20); adolescent welfare; adult human (21+); adult youth; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; balance; balance function; child maltreatment; child physical abuse; children; drug/agent; emerging adult; emotional abuse; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; gender difference; jobless; joblessness; juvenile; juvenile human; long-term study; mental illness; neglect; neglect and abuse; out of work; parent child interaction; parent offspring interaction; pediatric; peer; physical conditioning; prospective; psychological disorder; psychosocial; residence; resilience; school age; sex abuse; sexual dimorphism (noncellular); social disturbance; social support network; stressor; substance use; teenage; unemployed; violent; violent behavior; young adult; youngster",Longitudinal Study of Exposure to Family Violence,,49767,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,4,210989,
7759208,R01,HD,5,,02/01/2010,01/31/2011,,5R01HD050287-04,,NICHD:331045;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"GOLLAN, TAMAR H;",2923993;,5R01HD050287,02/20/2007,01/31/2012,"0-11 years old; Accounting; Affect; Age; Aged 65 and Over; Aging; Aging Process; Aging-Related Process; Apex of tongue; Back; Characteristics; Child; Child Youth; Children (0-21); Cognitive; Concept Formation; Cues; Disadvantaged; Dorsum; Elderly; Elderly, over 65; Environment; Equilibrium; Face; Frequencies (time pattern); Frequency; Generalized Growth; Goals; Growth; Human, Child; Investigators; Knowledge; Language; Language Development; Learning; Link; Mind; Modeling; Names; Participant; Pattern; Performance; Process; Production; Psycholinguistic; Psycholinguistics; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Retrieval; Senescence; Sound; Sound - physical agent; Speech; System; System, LOINC Axis 4; Testing; Tip of the Tongue; Tissue Growth; Translations; Variant; Variation; Vocabulary; Vocabulary Words; Work; acquiring language skills; advanced age; age dependent; age effect; age related; aging effect; balance; balance function; base; bilingualism; children; cognitive control; cognitive system; conceptual processes; cost; design; designing; elders; experience; experiment; experimental research; experimental study; facial; geriatric; interest; language acquisition; language learning; language processing; late life; later life; lexical; older adult; older person; ontogeny; performance tests; phonological; phonology; research study; senescent; senior citizen; sound; syntactic; syntax; theories; tongue apex; tool; youngster",The Bilingual Effect on Speaking,,50287,ZRG1,Special Emphasis Panel,,4,331045,
7753235,R01,HD,5,,01/01/2010,12/31/2010,PA-07-070,5R01HD051951-02,,NICHD:303650;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LOMA LINDA,UNITED STATES,PHYSIOLOGY,41,009656273,US,CA,92350,LOMA LINDA UNIVERSITY,"DUCSAY, CHARLES A;",1924714;,5R01HD051951,01/01/2009,12/31/2013,"0-6 weeks old; 21+ years old; ACTH; ACTH (1-39); ADRGND; Adenohypophysis; Adipose tissue; Adrenal Cortex; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Adult; Aeroseb-HC; Altitude; Anabolism; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Attenuated; Birth; Blood Plasma; CPT7; CYP11A; CYP11A1; CYP11A1 gene; CYP17; CYP17A1; CYP17A1 gene; Cetacort; Chronic; Chronic stress; Clinical; Cort-Dome; Cortef; Cortenema; Cortex of adrenal gland; Corticotropin; Corticotropin (1-39); Cortisol; Cortispray; Cortril; Coupled; Data; Dermacort; Development; Disease; Disorder; Eldecort; Enzymes; Face; Fatty Tissue; Fetal Age; Fetal Growth Restriction; Fetal Growth Retardation; Fetal Maturity, Chronologic; Fetus; Generalized Growth; Genes; Gestation; Gestational Age; Glucocorticoids; Growth; HuB219; Human, Adult; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hypoxia; Hypoxic; Hytone; IUGR; In Vitro; In element; Indium; Infant, Newborn; Intrauterine Growth Retardation; LEP-R; LEPR; LEPR Protein; Labor Onset; Laboratories; Leptin; Life; Maintenance; Maintenances; Mediating; Modeling; Neonatal; Nervous System, Pituitary; Newborn Infant; Newborns; Nutracort; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Organ; Ovis; Oxygen Deficiency; P450C17; P450SCC; Pars Anterior Pituitary Gland; Parturition; Physiologic; Physiological; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Plasma; Play; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Premature Birth; Preterm Birth; Process; Proctocort; Production; Programs (PT); Programs [Publication Type]; Recombinants; Reticuloendothelial System, Serum, Plasma; Role; S17AH; Serum, Plasma; Sheep; Stress; Testing; Therapeutic Glucocorticoid; Therapeutic Hydrocortisone; Tissue Growth; Work; acute stress; adipose; adult human (21+); base; biosynthesis; clinical relevance; clinically relevant; disease/disorder; facial; fetal; fetal hypoxia; fetus hypoxia; hypothalamic; in vivo; intrauterine growth restriction; leptin receptor; leptin-binding protein; newborn human (0-6 weeks); novel; ob/ob mouse; ontogeny; pregnant; premature; premature childbirth; premature delivery; prenatal; prenatal growth disorder; preterm delivery; prevent; preventing; programs; public health relevance; receptor expression; response; social role; stressor; suprarenal gland; unborn; white adipose tissue; yellow adipose tissue",Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus," PROJECT NARRATIVE The proposed studies are critical to our basic understanding of fetal adaptive mechanisms to chronic stress. Results from these studies will also have great potential for understanding the physiologic basis for clinical problems such as delayed development, intrauterine growth retardation, disease in the fetus and newborn, prenatal ""programming"" of the fetus to develop disease as an adult, and occult diseases that occur at high altitude.",51951,PN,Pregnancy and Neonatology Study Section,,2,303650,
7755045,R01,HD,5,,01/01/2010,12/31/2010,PA-07-070,5R01HD051999-03,,NICHD:331341;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,PHILADELPHIA,UNITED STATES,OBSTETRICS & GYNECOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GERTON, GEORGE L.;",1871157;,5R01HD051999,03/04/2008,12/31/2012,"2-Amino-6-Hydroxypurine; 2D PAGE; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; 6H-Purin-6-one, 2-amino-1,7-dihydro-; AKT; ATP pyrophosphate-lyase (cyclizing); ATP-protein phosphotransferase; Abbreviations; Ablation; Acrosome Reaction; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Akt protein; Animals; Artificial Insemination; Assisted Reproduction Technology; Assisted Reproductive Technology; Blood Serum; Cannot achieve a pregnancy; Capacitation of Spermatozoa; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Clear Cell; Competence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Development; Difficulty conceiving; EC 2.7; Environment; Epididymis; Epithelium; Eutelegenesis; Event; Family; Fertility/Fertilization; Fertilization; Fertilization in Vitro; Fertilized Egg; Fertilized Ovums; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP Exchange Factors; GDP-GTP Exchange Protein; GDP-GTP Reversing Factors; GEF; GSK-3; GTP GDP exchange factor; Gametes; Genes; Genetic; Genital System, Male, Testis; Genotype; Germ Cells; Germ-Line Cells; Glucocorticoids; Glycogen Synthase Kinase 3; Goals; Guanine; Guanine Nucleotide Exchange Factors; Guanine Nucleotide Exchange Protein; Guanine Nucleotide Releasing Factors; Guanyl-Nucleotide Exchange Factor; Guanyl-Nucleotide Releasing Factor; Hydrochloride; Hydrochloride Salt; ICSI; IVF; In Vitro; Infertility; Infertility, Male; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Intracellular Second Messengers; Intracytoplasmic Sperm Injections; Kinases; Light; Male Infertility; Mammals, Mice; Mass Spectrum; Mass Spectrum Analysis; Maturation of Spermatozoa; Membrane; Method LOINC Axis 6; Methodology; Mice; Molecular; Motility; Motility, Cellular; Murine; Mus; Ovum, Fertilized; PDE; PDK1; PDPK1; PDPK1 gene; PKA; PKB protein; PRO0461; Pathway interactions; Pattern; Phenotype; Phosphatidyl Inositol; Phosphatidylinositols; Phosphodiesterases; Phosphoinositides; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Photoradiation; Polyacrylamide Gel Electrophoresis, 2-D; Polyacrylamide Gel Electrophoresis, 2D; Polyacrylamide Gel Electrophoresis, Two-Dimensional; Process; Protein Analysis; Protein Kinase; Protein Kinase A; Protein Kinase B; Proteins; Proteomics; Proto-Oncogene Proteins c-akt; PtdIns; Public Health; RAC-PK protein; Reproductive Cells; Research; Role; Second Messenger Systems; Second Messengers; Serum; Sex Cell; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sperm; Sperm Capacitation; Sperm Injections, Intracytoplasmic; Sperm Maturation; Sperm Motility; Spermatogenesis; Spermatozoa; Structure of zygote; TCEP; Technology, Assisted Reproductive; Test-Tube Fertilization; Testicles; Testing; Testis; Therapeutic Glucocorticoid; Transphosphorylases; Transplantation; Two-Dimensional Polyacrylamide Gel Electrophoresis; Tyrosine Phosphorylation; Zygote; acrosomal reaction; adenosine 3'5' monophosphate; adenylcyclase; analog; base; biological signal transduction; c-akt protein; cAMP; cAMP-Dependent Protein Kinases; calcium bicarbonate; cell motility; clinical significance; clinically significant; contraceptive target; exchange factor; gene product; glycogen synthase a kinase; gsk-3 Gene Product; homologous recombination; hydroxyalkyl protein kinase; improved; infertile; initial cell; male; membrane structure; mutant; novel; oxidation; pathway; phosphoric diester hydrolase; phosphorylase b kinase kinase; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health medicine (field); rac protein kinase; related to A and C-protein; response; second messenger; sexual cell; social role; sperm cell; sperm function; sperm mobility; sperm protein; transplant; tris(2-carboxyethyl)phosphine; unable to bear children; zoosperm; zygote",Cyclic AMP Action During Sperm Function,,51999,CMIR,"Cellular, Molecular and Integrative Reproduction Study Section",,3,331341,
7764652,R01,HD,5,,02/01/2010,01/31/2011,PA-07-070,5R01HD055655-03,,NICHD:321874;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,STORRS-MANSFIELD,UNITED STATES,BIOCHEMISTRY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"LOTURCO, JOSEPH J;",1908560;,5R01HD055655,03/01/2008,01/31/2013,"0-11 years old; Adhesions; Affect; Binding; Binding (Molecular Function); Cell Adhesion; Cell Communication and Signaling; Cell Culture Techniques; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell physiology; Cellular Adhesion; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Child; Child Youth; Children (0-21); Collaborations; Deletion Mutation; Dendrites; Development; Dyslexia; Electroporation; Fiber; Functional impairment; Gene Targeting; GeneHomolog; Generalized Growth; Genes; Genetic; Growth; Homolog; Homologous Gene; Homologue; Human; Human, Child; Human, General; Image; Immigrations; In-Migration; Intracellular Communication and Signaling; Learning Disorders; Link; Mammals, Rodents; Man (Taxonomy); Man, Modern; Methods; Micro-tubule; Microtubules; Molecular Interaction; Motility; Motility, Cellular; Neocortex; Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurocyte; Neurons; Pathway interactions; Peptide Domain; Phenotype; Play; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Predisposition gene; Process; Protein Binding Domain; Protein Binding Motif; Protein Domains; Protein-Protein Interaction Domain; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radial; Reading Disabilities; Reading disability; Rodent; Rodentia; Rodentias; Role; SEQ-AN; Sequence Analyses; Sequence Analysis; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Subcellular Process; Susceptibility; Susceptibility Gene; Targetings, Gene; Tertiary Protein Structure; Testing; Tissue Growth; Word Blindness; Work; axon growth; axonal growth; biological signal transduction; cell motility; children; combinatorial; experiment; experimental research; experimental study; extracellular; functional disability; gain of function; gene function; gene product; homotypical cortex; imaging; in utero; isocortex; migration; neocortical; neopallium; neurobiological; neuron development; neuronal; novel; ontogeny; overexpression; pathway; predisposing gene; protein protein interaction; research study; social role; youngster",DYSLEXIA SUSCEPTIBILITY GENES AND MECHANISMS OF NEURONAL DEVELOPMENT,,55655,ZRG1,Special Emphasis Panel,,3,321874,
7905059,R01,HD,5,,02/01/2010,01/31/2011,PA-07-070,5R01HD057173-04,,NICHD:299259;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"PELPHREY, KEVIN A.;",6584226;,5R01HD057173,04/10/2008,01/31/2013,"0-11 years old; 21+ years old; 4 year old; 5 year old; 7 year old; 8 year old; Academic achievement; Achievement; Achievement Attainment; Address; Adult; Angular Gyrus; Animals; Biological; Brain; Brain region; Child; Child Youth; Childhood; Children (0-21); Cognition; Color; Comparative Study; Curriculum; Data; Dependency; Dependency (Psychology); Development; Disease; Disorder; Education for Intervention; Educational Curriculum; Educational Intervention; Encephalon; Encephalons; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Human; Human, Adult; Human, Child; Human, General; Image; Impairment; Individual Differences; Infant; Inferior; Instruction Intervention; Intelligence; Intraparietal Sulcus; LBUL; Laboratories; Lead; Learning; Link; Lobule; Longitudinal Studies; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Mathematics; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Neural Development; Neurobiology; Nuclear Magnetic Resonance Imaging; Numerical value; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Pattern; Pb element; Perception; Process; Programs (PT); Programs [Publication Type]; Reading; Recruitment Activity; Research; Research Design; Risk; Sampling; Scanning; Shapes; Staging; Structure; Structure of angular gyrus; Structure of intraparietal sulcus; Study Type; Sum; Training Intervention; Visual; Work; Zeugmatography; adult human (21+); angular gyrus; base; behavior measurement; behavioral measure; behavioral measurement; children; design; designing; disease/disorder; early childhood; eight year old; emotional dependency; fMRI; five year old; four year old; heavy metal Pb; heavy metal lead; imaging; instructional intervention; intervention program; intraparietal sulcus; long-term study; mathematical ability; mathematics disability; neural; neural circuit; neural circuitry; neural mechanism; neurobiological; neurodevelopment; neuroimaging; neuromechanism; novel; number sense; numerousy; parietal cortex; pediatric; programs; recruit; relating to nervous system; remediation; seven year old; spelling; standardize measure; study design; youngster",Neuroimaging of the Development of Neural Mechanisms for Number Processing,,57173,CP,Cognition and Perception Study Section,,4,299259,
7753237,R01,HD,5,,12/01/2009,11/30/2010,PA-07-070,5R01HD057871-02,,NICHD:300948;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,GAINESVILLE,UNITED STATES,PHARMACOLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"KELLER-WOOD, MAUREEN ;",1882570;,5R01HD057871,12/29/2008,11/30/2013,"ACTH; ACTH (1-39); ADRGND; Acceleration; Addison's disease; Adipose tissue; Adrenal Cortex Hormones; Adrenal Gland Excision; Adrenal Gland Hyperfunction; Adrenal Glands; Adrenal Hormone; Adrenal hormone preparation; Adrenalectomy; Adrenals; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Affect; Attenuated; Autoregulation; Birth; Blood Glucose; Blood Plasma; Blood Plasma Volume; Blood Sugar; Blood flow; Body Tissues; Body Weight, Fetal; Cardiac Output; Cetacort; Chronic stress; Clinical; Control Groups; Cort-Dome; Cortef; Cortenema; Corticoids; Corticosteroids; Corticotropin; Corticotropin (1-39); Cortisol; Cortispray; Cortril; Cushing Syndrome; Cushing's basophilism; D-Glucose; Data; Dermacort; Dextrose; Disease; Disorder; Eating; Eldecort; Fats; Fatty Tissue; Fatty acid glycerol esters; Fetal Growth; Fetal Heart; Fetal Weight; Fetus; Food Intake; GFAC; Gene Expression; Generalized Growth; Genes; Gestation; Glucose; Glucose Plasma Concentration; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Growth, Fetal; Homeostasis; Humulin R; Hydrocortisone; Hydrocortone; Hyperadrenalism; Hyperadrenocorticism; Hypercorticism; Hypoadrenalisms, Primary; Hytone; IGF-1; IGF-I; IGF-I-SmC; IGF1; Infant, Small for Gestational Age; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intermediary Metabolism; Ketones; Laboratories; Life; Liver; METBL; Maintenance; Maintenances; Malnutrition; Maternal Physiology; Metabolic Processes; Metabolism; Modeling; Muscle, Skeletal; Muscle, Voluntary; Neonatal; Normal Range; Normal Values; Novolin R; Nutracort; Nutrient; Nutritional Deficiency; Obesity; Organ; Ovis; Parturition; Perfusion; Physiological Homeostasis; Physiology; Plasma; Plasma Volume; Play; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Primary Adrenal Insufficiency; Primary Adrenocortical Insufficiency; Primary Hypoadrenalism; Proctocort; Production; Regulation; Relative; Relative (related person); Reporting; Reticuloendothelial System, Serum, Plasma; Role; Secondary to; Serum, Plasma; Sheep; Skeletal Muscle Tissue; Skeletal muscle structure; Small for Gestational Age Infant; Somatomedin C; Testing; Therapeutic Corticosteroid; Therapeutic Hydrocortisone; Time; Tissue Growth; Tissues; Triacylglycerol; Triglycerides; Undernutrition; Viscera; Visceral; adipose; adiposity; body system, hepatic; cardiac dimension; cardiac size; corpulence; corpulency; corpulentia; dietary deficiency; disease/disorder; experiment; experimental research; experimental study; feeding; fetal; fetal blood; glucose metabolism; glucose tolerance; heart dimension; heart dimension/size; heart output; heart size; hypercortisolism; improved; intrauterine growth; maternal stress; neonate; obese; obese people; obese person; obese population; ontogeny; organ system, hepatic; pituitary basophilism; postnatal; pregnant; public health relevance; research study; response; skeletal; skeletal muscle growth; small for gestational age; social role; stressed mothers; suprarenal gland; white adipose tissue; yellow adipose tissue",Effects of maternal cortisol on fetal and neonatal growth and metabolism," Project Narrative Diseases associated with either excess or deficient maternal secretion of the adrenal hormone cortisol have been found to be associated with reduction in fetal growth. Excess secretion of cortisol due to maternal stress has also been suggested as a contributing factor in small for gestational age babies; however, little is known about how changes in maternal cortisol influence either maternal physiology or fetal growth and metabolism. These studies will improve our understanding of the role of the normal increase in maternal cortisol that occurs in healthy pregnancies and how increases or decreases impact both fetal and neonatal growth and metabolism.",57871,ZRG1,Special Emphasis Panel,,2,300948,
7713981,R01,HD,5,,12/01/2009,11/30/2010,PA-07-070,5R01HD058880-02,,NICHD:319254;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,MEDFORD,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,07,073134835,US,MA,02155,TUFTS UNIVERSITY MEDFORD,"SLONIM, DONNA ;",8530919;,5R01HD058880,12/02/2008,11/30/2012,"0-6 weeks old; 21+ years old; Address; Adult; Amniotic Fluid; Analysis, Data; Aqua Amnii; Area; Arts; Bio-Informatics; Bioinformatics; Biology; Biomedical Research; Bite; Blood; Cancers; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Proliferation; Classification; Clinical Management; Collection; Computing Methodologies; Data; Data Analyses; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Detection; Development; Developmental Gene; Developmental Process; Diagnosis; Diagnosis, Antenatal; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Dimensions; Disease; Disorder; Environment; Expression Profiling; Expression Signature; Fetal Development; Fetal development of the mammalian embryo or fetus; Fetus; Gene Expression; Gene Products, RNA; Gene, Developmental; Genes; Genomics; Gestation; Goals; Hand; Health; Health Care Costs; Health Costs; Healthcare Costs; Human; Human Development; Human, Adult; Human, General; INFLM; Immune response; Infant; Infant, Newborn; Inflammation; Information Sciences; Infrastructure; Intrauterine Diagnosis; Knowledge; Lead; Learning; Learning, Machine; Life; Liquor Amnii; Machine Learning; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medical; Medicine; Metabolic Diseases; Metabolic Disorder; Methods; Methods and Techniques; Methods, Other; Modeling; Molecular Fingerprinting; Molecular Profiling; Monitor; Nature; Neonatal; Newborn Infant; Newborns; Outcome; Pathway interactions; Patients; Pb element; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Process; Public Health; RNA; RNA, Non-Polyadenylated; Rare Diseases; Rare Disorder; Research; Research Infrastructure; Reticuloendothelial System, Blood; Ribonucleic Acid; Sampling; Science of Medicine; Seminal; Sight; Source; Staging; System; System, LOINC Axis 4; Systematics; Systems Biology; Techniques; Technology; Testing; Thesaurismosis; Training; Translating; Translatings; Vision; Waters (Amniotic Fluid); Work; adult human (21+); analytical method; antepartum diagnosis; base; clinical data repository; clinical data warehouse; clinical relevance; clinically relevant; computational methodology; computational methods; computer methods; computer science; data repository; design; designing; developmental disease/disorder; developmental disorder; discovery mining; disease/disorder; fetal; heavy metal Pb; heavy metal lead; host response; human data; immunoresponse; in utero; innovate; innovation; innovative; interest; kernel methods; language translation; literature mining; literature searching; malignancy; member; metabolism disorder; minimally invasive; molecuar profile; molecular signature; neonate; neoplasm/cancer; new approaches; new diagnostics; newborn human (0-6 weeks); next generation diagnostics; novel; novel approaches; novel diagnostics; novel strategies; novel strategy; pathway; prenatal; public health medicine (field); public health relevance; relational database; statistical learning; success; support vector machine; text mining; text searching; tool; translational medicine; unborn",Translational Bioinformatics for Human Developmental Genomics,,58880,BDMA,Biodata Management and Analysis Study Section,,2,319254,
7916635,R01,HD,5,,01/01/2010,12/31/2010,PAR-07-420,5R01HD059762-02,,NICHD:341860;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,LOS ANGELES,UNITED STATES,INTERNAL MEDICINE/MEDICINE,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"HONG, YOUNG-KWON ;",7933232;,5R01HD059762,01/15/2009,12/31/2013,"ARP1 protein; Aberrant Chromosome; Ablation; Abnormalities, Chromosomal; Adopted; Aneuploid; Aneuploidy; Animal Model; Animal Models and Related Studies; Autoregulation; Back; Blood Vessels; Body Tissues; COUP transcription factor II; COUP-TF II; COUP-TFII; Cell Communication and Signaling; Cell Signaling; Cells; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome abnormality; Cytogenetic Aberrations; Cytogenetic Abnormalities; Data; Defect; Development; Diagnosis, Ultrasound; Diagnostic Factor; Dorsum; Down Syndrome; Down's Syndrome; Down-Regulation; Down-Regulation (Physiology); Downregulation; Downs Syndrome; Dropsy; Echography; Echotomography; Ectopic Expression; Edema; Embryo; Embryonic; Embryonic Fluid; Embryonic Tissue; Embryonic Tissue, Fluids, Secretions; Endothelial Cells; Endothelial Cells, Lymphatic; Exhibits; Fetus; Gene Copy Number; Gene Dosage; Gene Down-Regulation; Gene Targeting; Genes; Genetic; Gestation; Homeostasis; Human; Human Development; Human, General; Hydrops; Intracellular Communication and Signaling; Knockout Mice; Langdon Down syndrome; Link; Liquid substance; Lymphatic; Lymphatic Endothelial Cells; Lymphatic System; Lymphatic system (all sites); Lymphatic vessel; Man (Taxonomy); Man, Modern; Measurement; Mediating; Medical Imaging, Ultrasound; Messenger RNA; Methods; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Models, Molecular; Molecular; Molecular Models; Mongolism; Neck; Nuchal Translucency Measurement; Nuchal Translucency Screening; Nuclear Receptors; Nucleic Acid Biochemistry, Molecular Modeling; Null Mouse; Outcome; Phenotype; Physiological Homeostasis; Play; Pregnancy; Programs (PT); Programs [Publication Type]; Protein/Amino Acid Biochemistry, Molecular Modeling; RNA, Messenger; Regulation; Reporting; Repression; Reticuloendothelial System, Lymphatic System; Risk; Risk Assessment; Role; Screening procedure; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Swelling; Targetings, Gene; Tissues; Transcription Repression; Transcriptional Repression; Transgenic Mice; Trisomy 16 DS mouse; Trisomy 21; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Veins; Venous; apoAI regulatory protein-1; apolipoprotein AI regulatory protein 1; base; biological signal transduction; cell fate specification; chicken ovalbumin upstream promoter-transcription factor II; chromosome 21 trisomy syndrome; congenital acromicria syndrome; diagnostic ultrasound; embryo tissue; fluid; gene repression; insight; liquid; mRNA; model organism; molecular modeling; morbus Down; mouse Trisomy 16; mouse model; notch; notch protein; notch receptors; novel; nuclear receptor subfamily 2, group F, member 2; overexpression; prenatal; programs; pseudohypertrophic progressive muscular dystrophy; public health relevance; screening; screenings; social role; sonogram; sonography; sound measurement; trisomy 21 syndrome; ultrasound; ultrasound imaging; ultrasound scanning; unborn; vascular",Molecular Basis of Nuchal Edema,,59762,ZRG1,Special Emphasis Panel,,2,341860,
7756673,R01,HD,5,,01/01/2010,12/31/2010,PA-07-070,5R01HD059814-02,,NICHD:447796;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CLEVELAND,UNITED STATES,BIOMEDICAL ENGINEERING,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"KNUTSON, JAYME S.;",8645478;,5R01HD059814,01/10/2009,12/31/2013,"Active Follow-up; Activities of Daily Living; Activities of everyday life; Affect; Alternative Therapies; Animals; Apoplexy; Arm; Bilateral; Care, Health; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Clinical Research; Clinical Study; Contralateral; Control Groups; Coupling; Development; Disabled Persons; Disabled Population; Dose; Effectiveness; Electric Stimulation; Electrical Stimulation; Electrodes; Environment; Extremities; FES; FPS; FPS-FES Oncogene; Fingers; Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene; Funding; Goals; Hand; Hand functions; Handicapped; Health; Healthcare; Hemipareses; Hemiplegia; Impairment; Individual; Intention; Intervention; Intervention Strategies; Lead; Learning; Limb structure; Limbs; Link; Measurable; Membrum superius; Methods and Techniques; Methods, Other; Motor; Motor output; Movement; Muscle; Muscle Tissue; Non-Trunk; Occupational Therapy; Oncogene FES; Oncogene, FPS-FES; Palsy; Paralysed; Patients; Pb element; People with Disabilities; Persons with Disabilities; Physical Health Services / Rehabilitation; Pilot Projects; Plegia; Population; Prevalence; Principal Investigator; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recovery; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Severities; Site; Solid; Stimulus; Stroke; Study Section; Surface; Survivors; Techniques; Testing; Therapeutic; Thumb; Thumb structure; Time; Training; Treatment Efficacy; Treatment Period; Trials, Randomized Clinical; United States; Upper Extremity; Upper Limb; Upper arm; Using hands; Vascular Accident, Brain; Work; body movement; brain attack; cerebral vascular accident; chronic stroke; daily living functionality; design; designing; disability; disabled; disabled people; effective therapy; follow-up; function improvement; functional ability; functional capacity; functional improvement; functional restoration; heavy metal Pb; heavy metal lead; hemiparetic; instrument; intervention design; intervention development; interventional strategy; motor impairment; neuromuscular; novel; paralysis; paralytic; pilot study; post stroke; poststroke; public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; rehabilitative; restore function; restore functionality; restore lost function; sensory feedback; stroke; stroke rehab; stroke rehabilitation; therapeutic efficacy; therapeutically effective; therapy design; therapy development; time interval; treatment days; treatment design; treatment development; treatment duration; treatment effect; treatment response; upper limb hemiparesis",Contralaterally Controlled FES for Chronic Arm/Hand Hemiplegia: Single-Site RCT,,59814,MRS,Musculoskeletal Rehabilitation Sciences Study Section,,2,447796,
7769532,R01,HG,5,,02/01/2010,01/31/2011,PAR-07-344,5R01HG004708-02,,NHGRI:264190;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,NEW BRUNSWICK,UNITED STATES,PHYSICS,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"MOROZOV, ALEXANDRE V;",8896591;,5R01HG004708,02/13/2009,01/31/2013,"Affect; Affinity; Amino Acids; Animal Model; Animal Models and Related Studies; Assay; Base Pairing; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biological Models; Biology; Biomedical Engineering; Cells; Chemical Models; Chemotherapy-Hormones/Steroids; Chromatin; Chromatin Assembly; Chromatin Modeling; Chromatin Structure; Collaborations; Combining Site; Complex; D-Glucose; DNA; DNA Binding; DNA Binding Interaction; DNA Sequence; DNA-Binding Proteins; Data Set; Dataset; Degradation, mRNA; Deoxyribonucleic Acid; Dextrose; Digestion; Dinucleoside Phosphates; Drug Design; Elements; Endocrine Gland Secretion; Environment; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equilibrium; Eukaryota; Eukaryote; Eukaryotic Cell; Exercise; Exercise, Physical; Free Energy; GWAS; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genome; Genomics; Glucose; Heat Shock; Heat-Shock Reaction; Heat-Shock Response; Histones; Hogness Box; Homologous Protein; Hormones; In Vitro; Large-Scale Sequencing; Left; Libraries; Link; Location; Maps; Measures; Mechanics; Medicine; Model System; Modeling; Models, Biologic; Models, Chemical; Modification; Molecular Interaction; Motor; Mutation; Nucleosomes; Nucleotides; Pathway interactions; Pattern; Play; Position; Positioning Attribute; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Homolog; ProteinHomolog; Proteins; Reactive Site; Relaxation; Research; Role; Science of Medicine; Screening procedure; Shapes; Structure; TATA Box; Therapeutic Agents; Therapeutic Hormone; Training; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Translating; Translatings; Universities; Work; Yeasts; aminoacid; balance; balance function; base; bioengineering; bioengineering/biomedical engineering; chromatin remodeling; density; design; designing; dinucleotide; eukaryotida; experiment; experimental research; experimental study; flexibility; gene product; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide; genome-wide analysis; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; improved; in vivo; insight; language translation; mRNA Transcript Degradation; model organism; neglect; novel; pathway; preference; public health relevance; reconstitute; reconstitution; research study; response; screening; screenings; social role; synthetic biology; transcription factor; whole genome association studies; whole genome association study",Biophysical Models for Prediction and Design of Eukaryotic Chromatin Structure an," Project Narrative The ability to predict how chromatin structure affects gene expression will open a novel pathway towards numerous applications in biology and medicine, including rational drug design and new, chromatin-based approaches to rewiring cellular networks. The ability to exercise precise transcriptional control over the amount and the type of proteins produced by the cell through making directed changes in chromatin structure will find many uses in bioengineering and synthetic biology, including production of synthetic hormones, enzymes, and therapeutic agents.",4708,MSFD,Macromolecular Structure and Function D Study Section,,2,264190,
7760073,R01,HG,5,,01/01/2010,12/31/2010,PA-07-458,5R01HG004845-02,,NHGRI:347088;,2010,NATIONAL HUMAN GENOME RESEARCH INSTITUTE,,ITHACA,UNITED STATES,BIOCHEMISTRY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"LIS, JOHN THOMAS;",1867285;,5R01HG004845,01/24/2009,12/31/2011,"Active Sites; Analysis, Data; Animal Model; Animal Models and Related Studies; Assay; Basic Research; Basic Science; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; CHIP assay; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; ChIP (chromatin immunoprecipitation); Chromosomes; Code; Coding System; Coupled; DNA; DNA-Dependent RNA Polymerase I; DNA-Dependent RNA Polymerase II; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Data Analyses; Deoxyribonucleic Acid; Development; Diagnostic; Disease; Disorder; Drosophila; Drosophila genus; EC 2.7.7.6; ES cell; Embryo; Embryonic; Eukaryota; Eukaryote; Fruit Fly, Drosophila; Gene Expression; Gene Products, RNA; Gene Transcription; Generations; Genes; Genetic Transcription; Genome; Genome, Human; Goals; Hormonal; Human; Human Cell Line; Human Genome; Human, General; Infection; International; Intracellular Communication and Signaling; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Methods; Mice; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Monitor; Mother Cells; Mouse Cell Line; Murine; Mus; Nuclear; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleotides; Nutritional; Organism; Pattern; Play; Polymerase; Polymers; Position; Positioning Attribute; Procedures; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA; RNA Expression; RNA Polymerase A; RNA Polymerase B; RNA Polymerase I; RNA Polymerase II; RNA Polymerases; RNA, Non-Polyadenylated; Reading; Regulation; Relative; Relative (related person); Resolution; Ribonucleic Acid; Role; Run-On Assays; Running; Signal Transduction; Signal Transduction Systems; Signaling; Sites, Active; Stem cells; Testing; Transcription; Transcription Elongation; Transcription Initiation Site; Transcription Regulation; Transcription Start Site; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Variant; Variation; abstracting; biological signal transduction; chromatin immunoprecipitation; disease/disorder; embryonic stem cell; eukaryotida; fruit fly; genome-wide; interest; living system; model organism; novel; response; social role; stem cell of embryonic origin; tool; transcription factor; ultra high resolution",Quantifying the Genome-wide Distribution of Transcriptionally-engaged RNA Polymer,,4845,MGB,Molecular Genetics B Study Section,,2,347088,
7755007,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL020605-29,,NHLBI:226500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,PHYSIOLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"BOHLEN, HAROLD G;",1903404;,5R01HL020605,04/01/1977,01/31/2011,"ATRC1; Absorption; Affect; Amino Acids; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Arginine; Arginine, L-Isomer; Arteries; Arterioles; Blood; Blood Coagulation Factor IV; Blood Vessels; Blood capillaries; Body Tissues; Bradykinin; Brain; CAT-1 Transport Protein; CAT-1 Transporter; CNOS; Ca++ element; Calcium; Calcium ion; Capillaries; Capillary; Capillary, Unspecified; Cationic Amino Acid Transporter 1; Cells; Cerebrum; Coagulation Factor IV; Communication; Constitutive NOS; Data; Distal; ECNOS; ENOS; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Derived Relaxing Factor; Extravasation; Factor IV; Feedback; Generations; Grant; Hemoglobin; In Vitro; Intestinal; Intestinal Absorption; Intestines; Investigators; Ion Channels, Sodium; Ions; L-Arginine; L-Lysine; Leakage; Lysine; Measurement; Metabolic; Methods and Techniques; Methods, Other; Molecular Transport; Mononitrogen Monoxide; Movement; Muscle, Smooth, Vascular; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Na element; Na(+)-Ca(2+) Antiporter; Na(+)-Ca(2+) Exchanger; Na+ element; Nervous System, Brain; Nitric Oxide; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nutrient; O element; O2 element; Organ; Oxygen; Oxygen measurement, partial pressure, arterial; Pilot Projects; Process of absorption; Production; Regulation; Research Personnel; Researchers; Resistance; Rest; Reticuloendothelial System, Blood; SLC7A1 Transporter; Sodium; Sodium Channel; Sodium-Calcium Antiporter; Sodium-Calcium Carrier; Sodium-Calcium Exchanger; Solute Carrier Family 7-(Cationic Amino Acid Transporter, y+ System), Member 1; Source; Spillage; Structure of arteriole; Structure of venule; System; System, LOINC Axis 4; Techniques; Time; Tissues; Transport Process; Venules; absorption; aminoacid; antiport; arterial pO2; arteriole; base; body movement; bowel; capillary; constriction; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; extracellular; gastrointestinal absorption; human NOS3 protein; in vivo; kallidin 9; kallidin I; oxygen tension; pilot study; resistant; response; sodium ion; vascular; vascular bed; venule",Microvascular Regulation During Intestinal Absorption,,20605,HM,Hypertension and Microcirculation Study Section,,29,226500,
7754386,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL025739-26,,NHLBI:221475;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,PHYSIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"FORSTER, HUBERT V;",1867004;,5R01HL025739,06/01/1986,01/31/2011,"21+ years old; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT-2A Gene; 5-HT2A; 5-Hydroxytryptamine; 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene; 5-Hydroxytryptamine Receptor 2A Gene; 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-; 5HT; Abdomen; Abdominal; Acute; Address; Adolescent; Adolescent Youth; Adult; Agonist; Air Conditioning; Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; Apnea, Central; Apnea, Sleep; Area; Aspiration, Respiratory; Behavior; Bilateral; Blood gas; Brain; Brain Stem; Brainstem; Breathing; Caprine Species; Central Sleep Apnea; Central Sleep Apnea Syndrome; Chronic; Common Rat Strains; Complex; Conditionings, Air; Conflict; Conflict (Psychology); Contralateral; Cot Death; Coupled; Crib Death; Cytochrome Oxidase; Cytochrome-c Oxidase (Complex IV); D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin; D-Ala2-NMe-Phe4-Gly-ol Enkephalin; DAGO; DAGOL; DAMGE; DAMGO; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disadvantaged; Disease; Disorder; Electron Transport Complex IV; Encephalon; Encephalons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; Enteramine; Face; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Generations; Glutamate Receptor; Goat; HTR2; HTR2 Gene; HTR2A; HTR2A gene; Hippophaine; Human; Human, Adult; Human, General; Hybrids; Hypoventilation, Central Alveolar; Hypoxia; Hypoxic; Ibotenic Acid; Implant; In Vitro; Inhalation; Inhaling; Injection of therapeutic agent; Injections; Inspiration, Respiratory; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-nalpha-methyl-; Lead; Lesion; Life; Lung diseases; Mammalia; Mammals; Mammals, General; Mammals, Goats; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Metabolic Marker; Micro-tubule; Microtubules; Muscle; Muscle Tissue; NK-1 Receptors; NK1R; NKIR; Neonatal; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neurotoxins; Ondine Syndrome; Opioid Receptor; Oxygen Deficiency; Pace Stimulators; Pacemakers; Pattern; Pb element; Phase; Physiologic; Physiological; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Preparation; Pulmonary Diseases; Pulmonary Disorder; Pump; Rat; Rattus; Receptors, Neurokinin-1; Receptors, Opiate; Recovery; Respiration; Respiratory Disease; Respiratory Disorder; Respiratory Muscles; Respiratory System Disease; Respiratory System Disorder; Role; SIDS; SP-P Receptors; Serotonin; Serotonin 5-HT-2 Receptor Gene; Side; Site; Sleep; Sleep Apnea Syndromes; Sleep Apnea, Central; Sleep Hypopnea; Sleep-Disordered Breathing; Sleep-Disordered Breathing, Central; Sleep-Disordered Breathings, Central; Stimulators, Electrical, Pace; Substance P Receptor; Sudden Infant Death; Sudden Unexpected Death of Infant; Sudden Unexpected Infant Death; Sudden infant death syndrome; Synapses; Synaptic; TAC1R; TACR1; Tachykinin Receptor 1; Testing; Time; Tyr-Ala-Gly-(NMe)Phe-Gly-ol; Ventilatory Muscles; adult human (21+); attenuation; awake; base; cytochrome c oxidase; disease/disorder; experience; facial; heavy metal Pb; heavy metal lead; immunoreactivity; in vivo; inspiration; juvenile; juvenile human; lung disorder; neurodegenerative illness; neuronal; neurotoxic; neurotoxicant; neurotrophic factor; neurotrophin; neurotropic; neutrophin; novel; respiratory; respiratory mechanism; response; restoration; social role",Control of breathing during physiological conditions,,25739,RIBT,Respiratory Integrative Biology and Translational Research Study Section,,26,221475,
7765485,R01,HL,5,,03/01/2010,02/28/2011,,5R01HL030260-25,,NHLBI:348346;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"BUSIJA, DAVID W;",1864987;,5R01HL030260,01/01/1991,02/28/2011,"Animal Neonates; Animals; Animals, Newborn; Astrocytes; Astrocytus; Astroglia; Blood Coagulation Factor IV; Blood Vessels; Body Tissues; Brain; C protein; CBP protein (citrate-binding); Ca++ element; Calcium; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cerebrovascular Circulation; Cerebrum; Cessation of life; Chemicals; Coagulation Factor IV; Data; Death; Encephalon; Encephalons; Endothelial Cells; Event; Factor IV; Generations; Hour; Hypoxia; Hypoxic; In Vitro; Injury; Ischemia; K element; Laboratories; Lead; Link; Medical; Mitochondria; Mitochondrial Swelling; Neonatal; Nerve Cells; Nerve Unit; Nervous; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neurological Damage; Neurological Injury; Neurological trauma; Neurons; Newborn Animals; Oxygen Deficiency; PKC; Pb element; Peptide Biosynthesis, Ribosomal; Phase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Potassium; Production; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase C; Protein Synthesis, Ribosomal; Proteins; Protocols, Treatment; RGM; Regimen; Regulation; Reperfusion Therapy; Role; Severities; Signal Pathway; Stress; Swelling; Testing; Tissues; Trauma, Nervous System; Treatment Protocols; Treatment Regimen; Treatment Schedule; adult animal; brain tissue; cerebral blood flow; cerebral circulation; cerebrocirculation; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; gene product; heavy metal Pb; heavy metal lead; in vivo; intervention development; mature animal; mitoK(ATP); mitoKATP; mitochondrial; mitochondrial K(ATP) channel; neonatal animal; neonate; neural; neuronal; novel; novel therapeutic intervention; preconditioning; protein synthesis; relating to nervous system; reperfusion; response; social role; therapy development; treatment development; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; vascular",Regulation of Cerebral Blood Flow,,30260,VCMB,Vascular Cell and Molecular Biology Study Section,,25,348346,
7749550,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL032257-26,,NHLBI:440636;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,SURGERY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"DAMIANO, RALPH J;",1902056;,5R01HL032257,08/08/1983,12/31/2013,"A-V Node; AF 2; AF2; AV Node; Ablation; Accounting; Active Follow-up; Admission; Admission activity; Adoption; Affect; Age; American; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animals; Anti-Arrhythmia Agents; Anti-Arrhythmia Drugs; Anti-Arrhythmics; Antiarrhythmia Agents; Antiarrhythmia Drugs; Antiarrhythmic Drugs; Arrhythmia; Atrial; Atrial Fibrillation; Atrial Function, Right; Atrio-Ventricular Node; Atrioventricular Node; Atrium, Left; Au element; Auricle of Heart; Auricular Fibrillation; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cardiac Arrhythmia; Cardiac Atrium; Cardiac Diseases; Cardiac Disorders; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cardioscopes; Characteristics; Clinical Research; Clinical Study; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Country; Development; Diagnosis; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Drops; Drug Therapy; Drugs; EMI scan; Electrophysiology; Electrophysiology (science); FLR; Failure (biologic function); Funding; Future; Goals; Gold; Grant; HOSP; Hand; Heart Arrhythmias; Heart Atrium; Heart Diseases; Hospitals; Human; Human, General; Image; Individual; Investigation; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Laboratories; Left; Left Atrium of Heart; Left atrial structure; Lesion; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Modification; Monitor; Myocardial Ischemia; Neurophysiology / Electrophysiology; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiologic; Physiological; Population; Prevalence; Procedures; Public Health; Pulmonary veins; Recurrence; Recurrent; Research Personnel; Researchers; Right Atrial Function; Science of Anatomy; Series; Structure of atrioventricular node; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Symptoms; Tachyarrhythmias; Techniques; Testing; Therapeutic; Time; Tomodensitometry; Tomography, Xray Computed; Translating; Translatings; United States; Unnecessary Procedures; Ventricular Arrhythmia; WPW Syndrome; Wolf-Parkinson-White Syndrome; Wolff-Parkinson-White Syndrome; Work; X-Ray Computed Tomography; aging population; anatomy; antiarrhythmic agent; arrhythmic agent; atrioventricular node; atrium; base; cardiac rhythm; catscan; clinical efficacy; clinical practice; comparative; computed axial tomography; computerized axial tomography; computerized tomography; design; designing; drug/agent; electrocardiographic monitor; experiment; experimental research; experimental study; failure; follow-up; heart disorder; heart function; heart ischemia; heart rhythm; heart surgery; hemodynamics; imaging; improved; innovate; innovation; innovative; language translation; model organism; myocardial ischemia/hypoxia; myocardium ischemia; novel; patient population; public health medicine (field); public health relevance; randomized trial; research study; success; surgery; tachyrhythmia",SURGICAL TREATMENT OF CARDIAC ARRHYTHMIAS," Atrial fibrillation affects over two million Americans and drug therapy is ineffective. Previously, this grant has resulted in the development of a curative procedure called the Cox-Maze procedure. The present proposal is design to improve and simplify this surgical treatment, maintain the high cure rate, and minimize the effects on heart function, thus making it available to a wider patient population.",32257,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,26,440636,
7765555,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL034161-22,,NHLBI:342000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,ANATOMY/CELL BIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"NERBONNE, JEANNE M.;",1866984;,5R01HL034161,04/01/1986,01/31/2011,"21+ years old; Actins; Action Potentials; Adult; C-terminal; Cardiac; Cardiac Myocytes; Cardiocyte; Cell surface; Cell-Extracellular Matrix; Cellular Matrix; Complexes, Macromolecular; Cytoskeletal System; Cytoskeleton; ECM; Extracellular Matrix; Generations; Goals; Heart myocyte; Human, Adult; In Situ; In Vitro; Individual; Investigators; Ion Channel; Ionic Channels; KCNK2 gene product; Laboratories; Macromolecular Complexes; Macromolecular Protein Complexes; Mammals, Mice; Mediating; Membrane Channels; Mice; Mink; Molecular; Molecular Genetic; Molecular Genetics; Multiprotein Complexes; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardium; Myocytes; Myocytes, Cardiac; Physiologic; Physiological; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Regulation; Regulatory Protein; Research; Research Personnel; Researchers; Role; System; System, LOINC Axis 4; TREK gene product; TREK-1; TREK-1 gene product; TREK-1 potassium channel; TREK1 gene product; Testing; Time; V (voltage); Ventricular; adult human (21+); base; cardiac muscle; cardiomyocyte; experiment; experimental research; experimental study; gene product; genetic regulatory protein; heart muscle; in vivo; insight; intracellular skeleton; potassium channel protein TREK-1; programs; regulatory gene product; research study; social role; voltage",Ion Channel Regulation and Modulation in Cardiac Muscle,,34161,ZRG1,Special Emphasis Panel,,22,342000,
7768456,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL036783-23,,NHLBI:338000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PHYSIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"GADSBY, DAVID C;",1881084;,5R01HL036783,04/01/1987,01/31/2012,"ATP phosphohydrolase (Na+ K+ transporting); Acocantherin; Acolongifloroside K; Assay; Axon; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-1,5,11,14,19-pentahydroxy-, (1beta,3beta,5beta,11alpha)-; Cardiac Glycosides; Cardiac Myocytes; Cardiocyte; Cardiotonic Steroids; Cavia; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Characteristics; Charge; Chemicals; Combining Site; Core Protein; Coupled; Coupling; Cysteine; Cytoplasmic Membrane; Dystonia 12; Embryo; Embryonic; Familial Hemiplegic Migraine; Funding; G-Strophanthin; Gated Ion Channel; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; Guinea Pigs; Half-Cystine; Heart myocyte; Hereditary; Homology Modeling; Human; Human, General; Inherited; Intracellular Communication and Signaling; Ion Channel; Ion Channel Gating; Ion Channel Gatings; Ion Pumps; Ion Transport; Ionic Channels; Ions; L-Cysteine; Learning; Life; Ligands; Light; Link; Location; Mammals, Guinea Pigs; Man (Taxonomy); Man, Modern; Marine Toxins; Measurement; Measures; Membrane; Membrane Channels; Membrane Potentials; Methods; Models, Structural; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Monitor; Movement; Msec; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Mutagenesis, Site-Directed; Mutation; Myocytes; Myocytes, Cardiac; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Na+ K+ ATPase; Nucleotides; Oocytes; Ouabain; Ovocytes; Pathway interactions; Photoradiation; Physiologic; Physiological; Plasma Membrane; Potassium Pump; Proteins; Pump; Rapid onset Dystonia Parkinsonism; Reaction; Reactive Site; Reagent; Relaxation; Renal Cell; Resistance; Resolution; Resting Potentials; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump; Solutions; Squid; Structural Models; Structure; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Time; Transmembrane Potentials; Transport Reaction; V (voltage); Ventricular; Work; Xenopus; Xenopus oocyte; base; biological signal transduction; body movement; cardiomyocyte; conformation; conformational conversion; conformational state; conformational transition; digoxin receptor; experiment; experimental research; experimental study; extracellular; gene product; genome mutation; heart cell; kidney cell; marine biotoxin; membrane structure; millisecond; mutant; novel; palytoxin; pathway; plasmalemma; reagent testing; research study; resistant; sodium potassium exchanging ATPase; stoichiometry; tool; voltage; voltage clamp",Na/K Pump Current in Isolated Heart Cells,,36783,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,23,338000,
7758227,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL046457-18,,NHLBI:433659;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"MICHEL, THOMAS ;",1862371;,5R01HL046457,07/01/1997,01/31/2012,"1-Phosphatidylinositol 3-Kinase; 3-Hydroxy-3-methylglutaryl CoA Reductase; 3-hydroxy-3-methylglutaryl coenzyme A Inhibitors; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Actins; Active Oxygen; Acylation; Agonist; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoregulation; Bizzozero's corpuscle/cell; Blood Platelets; Blood Pressure; Blood Vessels; CNOS; Caveolae; Caveolas; Caveolin Proteins; Caveolins; Cell Communication and Signaling; Cell Culture System; Cell Signaling; Cell Surface Receptors; Cellular Matrix; Cellular Regulation; Constitutive NOS; Cytoskeletal System; Cytoskeleton; Deetjeen's body; Dephosphorylation; Disease; Disorder; Dysfunction; EC 1.14.13.39; EC 2.7; ECNOS; EDRF Synthase; ENOS; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Functional disorder; Funding; GTP Phosphohydrolases; GTPases; Generations; Goals; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Guanylyl Cyclase-Activating Factor Synthase; HMG CoA Reductases; HMG-CoA Reductase Inhibitors; Hayem's elementary corpuscle; Health; Homeostasis; Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA reductase; Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase; Inhibitors, Hydroxymethylglutaryl-CoA; Inhibitors, Hydroxymethylglutaryl-Coenzyme A; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Investigators; Isoforms; Kinases; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Link; Marrow platelet; Methods; Mice, Transgenic; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Mononitrogen Monoxide; NADPH Oxidase; NADPH-Diaphorase; NIH; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; National Institutes of Health; National Institutes of Health (U.S.); Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Oxidation-Reduction; Oxidative Stress; Oxygen Radicals; PI-3 Kinase; PI-3K; PI3-Kinase; Pathway interactions; Pb element; Phosphatases; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Physiopathology; Platelet aggregation; Platelets; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Preparation; Pro-Oxidants; Production; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Isoforms; Protein Localization; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Trafficking; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; PtdIns 3-Kinase; RNA, Small Interfering; Reactive Oxygen Species; Receptor Protein; Receptors, Cell Surface; Redox; Regulation; Regulatory Pathway; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Rest; Reticuloendothelial System, Platelets; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Small G-Proteins; Small GTPases; Small Interfering RNA; Sphingolipids; Staging; Statins, HMG-CoA; Subcellular Protein Targeting; Subcellular Targeting, Physiological; Syndrome; System; System, LOINC Axis 4; TC-25 GTP-Binding Protein; Testing; Thrombocytes; Transgenic Mice; Transgenic Model; Transphosphorylases; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; United States National Institutes of Health; VEGFs; Vascular Endothelial Growth Factors; Vegf; Work; angiogenesis; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; cell growth regulation; disease/disorder; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; enzyme activity; experiment; experimental research; experimental study; gene product; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; human NOS3 protein; interventional strategy; intracellular protein transport; intracellular skeleton; knock-down; mutant; new technology; novel; oxidation reduction reaction; pathophysiology; pathway; programs; rac1 GTP-Binding Protein; rac1 Protein; ras-Related C3 Botulinum Toxin Substrate 1; receptor; research study; response; siRNA; social role; sphingosine 1-phosphate; thrombocyte/platelet; vascular",Endothelial nitric oxide synthase,,46457,VCMB,Vascular Cell and Molecular Biology Study Section,,18,433659,
7762714,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL049989-16,,NHLBI:383750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"RODEN, DAN M;",1885740;,5R01HL049989,08/01/1994,01/31/2012,"Address; Antigenic Determinants; Arrhythmia; Binding Determinants; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cell Surface Proteins; Cell surface; Complementary DNA; DNA, Complementary; Data; Development; Disease; Disorder; Drugs; Dysfunction; ECG; EKG; ES cell; Electrocardiogram; Electrocardiography; Electrophysiology; Electrophysiology (science); Epitopes; Exhibits; Functional disorder; Generations; Genes; Genetic Alteration; Genetic Change; Genetic defect; Heart; Heart Arrhythmias; Heart Diseases; Heterozygote; Human; Human, General; In Vitro; Individual; Intervention; Intervention Strategies; Intracellular Second Messengers; Investigation; Investigators; Ion Channel; Ion Channels, Sodium; Ionic Channels; Isoforms; Laboratories; Link; Long QT Syndrome; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane Channels; Methods; Methods and Techniques; Methods, Other; Mice; Modification; Murine; Mus; Mutation; Na element; Neurophysiology / Electrophysiology; Organism; Outcomes Research; Penetrance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiology; Physiopathology; Predisposition; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins, Cell Surface; Public Health; Research; Research Personnel; Research Resources; Research, Outcomes; Researchers; Resources; Second Messenger Systems; Second Messengers; Sodium; Sodium Channel; Structure; Surface; Susceptibility; Syndrome; System; System, LOINC Axis 4; Techniques; Technology; Testing; Therapeutic; Time; Variant; Variation; animal model development; base; cDNA; cardiac rhythm; clinical phenotype; disease/disorder; drug/agent; embryonic stem cell; experiment; experimental research; experimental study; genome mutation; heart disorder; heart rhythm; in vivo; interventional strategy; living system; loss of function; mouse model; mutant; mutation carrier; pathophysiology; programs; public health medicine (field); recombinase; research study; second messenger; stem cell of embryonic origin",Modulation of Cardiac Repolarization,,49989,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,16,383750,
7763904,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL052585-14,,NHLBI:315000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,PATHOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"NICOSIA, ROBERTO ;",1905567;,5R01HL052585,04/01/1995,01/31/2011,"21+ years old; ANG1; ANGPT1; Adult; Angiopoietin 1 Receptor; Angiopoietin Receptor Tie-2; Angiopoietin-1; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Vessels; CD14; CD14 Antigen; CD14 Monocyte Differentiation Antigen; CD14 gene; CD14 molecule; CD14 receptor; CD202B Antigen; CSBP1; CSBP2; CSPB1; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Patient; Cancers; Cardiac artery; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Isolation; Cell Locomotion; Cell Migration; Cell Movement; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Cellular Migration; Common Rat Strains; Confocal Microscopy; Coronary artery; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Cytokines, Chemotactic; Dependency; Dependency (Psychology); Disease; Disorder; Dose; ELISA; EXIP; Electromagnetic, Laser; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Epithelial-Specific Protein Receptor Tyrosine Kinase TIE-2; FLR; Failure (biologic function); Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Goals; Grant; Heart artery; Homologous Chemotactic Cytokines; Human, Adult; Immune; Immune response; Immune system; In Vitro; Injury; Intercrines; Investigators; Knowledge; Lasers; Life; Ligands; MAPK14; MAPK14 gene; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Mediating; Methods; Mice; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Microscopy; Microscopy, Confocal; Modeling; Molecular; Molecular Interaction; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Motility; Motility, Cellular; Murine; Mus; Mxi2; Myeloid Cell-Specific Leucine-Rich Glycoprotein; Organ; Organ Culture; Organ Culture Techniques; Organ System, Cardiovascular; PRKM14; PRKM15; PTK Receptors; Pathway interactions; Pattern; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Play; Process; Production; RT-PCR; RTK; RTPCR; Radiation, Laser; Rat; Rattus; Receptor Protein-Tyrosine Kinases; Receptor, LPS; Receptor, Lipoglycan; Receptor, TIE-2; Receptors, Lipopolysaccharide; Recombinants; Regulation; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; SAPK2A; SIS cytokines; Signal Pathway; Signaling Molecule; Small Inducible Cytokine A2; System; System, LOINC Axis 4; TEK Tyrosine Kinase; TEK Tyrosine Kinase, Endothelial; TIE-2 Receptor; TIE-2 Receptor Tyrosine Kinase; TIE-2-RTK; TIE2 Tyrosine Kinase; TIL4; TLR2; TLR2 receptor; TLR4; TLR4 gene; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TNF-binding protein I, human; TNFR55 protein, human; TNFRSF1A; TNFRSF1A protein, human; TNFalpha receptor; TOLL; Tek Receptor; Tie2 Receptor; Time; Toll-Like Receptor 2; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; Transgenic Mice; Transgenic Organisms; Transmembrane Receptor Protein Tyrosine Kinase; Tumor Necrosis Factor; Tumor Necrosis Factor Binding Protein 1; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Receptor Superfamily, Member 1A; Tumor Necrosis Factor Receptor Type 1; Tumor Necrosis Factor-Alpha Receptor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tunica Interna Endothelial Cell Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase Receptor TEK; Tyrosine-Protein Kinase Receptor TIE-2; Up-Regulation; Up-Regulation (Physiology); Upregulation; VEGFs; Vascular Endothelial Growth Factors; Vascular, Heart; Vegf; Work; Wound Healing; Wound Repair; adult human (21+); angiogenesis; angiogenesis therapy; atheromatosis; atherosclerotic vascular disease; base; body system, allergic/immunologic; cancer progression; cell motility; cell sorting; chemoattractant cytokine; chemokine; circulatory system; cytokine; design; designing; disease/disorder; emotional dependency; experiment; experimental research; experimental study; failure; hToll; host response; human TNFRSF1A protein; immunocytochemistry; immunoresponse; in vivo Model; injury response; insight; macrophage; malignancy; microarray technology; neoplasm progression; neoplasm/cancer; neoplastic progression; neutralizing antibody; novel; organ system, allergic/immunologic; p140 TEK; p38; p38 MAPK Gene; p38Alpha; paracrine; pathway; peripheral blood vessel disorder; precursor cell; research study; response; response to injury; reverse transcriptase PCR; social role; therapeutic angiogenesis; therapeutic development; tissue repair; transgenic; tumor necrosis factor (unspecified); tumor necrosis factor alpha receptor; tumor necrosis factor binding protein 1, human; tumor necrosis factor receptor 1 (55kD) protein, human; tumor necrosis factor receptor superfamily, member 1A protein, human; tumor progression; vascular",PARACRINE REGULATION OF ANGIOGENESIS BY MURAL CELLS,,52585,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,14,315000,
7755870,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL054826-14,,NHLBI:375459;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,TUCSON,UNITED STATES,BIOCHEMISTRY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"WALKER, FRANCES ANN;",1867711;,5R01HL054826,07/01/1995,01/31/2013,"1H-Imidazole-4-ethanamine; Affect; American; American Trypanosomiasis; Apoproteins; Arg-Lys; Bed Bugs; Bedbugs; Binding; Binding (Molecular Function); Biological; Biosynthetic Proteins; Blood; Bryophyta; Bryophyte; Cause of Death; Cell Death; Cells; Chagas Disease; Charge; Chemical Dynamics; Cimex; Cleaved cell; Codon, Initiation; Codon, Initiator; Codon, Start; Collaborations; Complex; Distant; E coli; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Escherichia coli; Fe element; Feces; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Gastrointestinal Tract, Feces; Goals; Grant; Head and Neck, Saliva; Head and Neck, Salivary Glands; Heme; Heme Proteins; Heme b; Hemeproteins; Histamine; Histamine Liberation; Histamine Release; Human; Human, General; Individual; Initiator Codon; Insecta; Insects; Invertebrates, Insects; Investigation; Iron; Kinetic; Kinetics; Laboratories; Latin America; Ligand Binding; Ligands; Lung; Man (Taxonomy); Man, Modern; Measures; Metalloproteins; Molecular Interaction; Mononitrogen Monoxide; Mosses; Muscle, Cardiac; Muscle, Heart; Myocardium; N-terminal; NH2-terminal; NP protein; Names; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Parasites; Physicians; Platelet aggregation; Play; Property; Property, LOINC Axis 2; Prosthesis; Prosthetic device; Prosthetics; Protein Dynamics; Proteins; Protoheme; Protoheme IX; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Recombinant Proteins; Recombinants; Resolution; Respiratory System, Lung; Reticuloendothelial System, Blood; Rhodnius; Rivers; Roentgen Rays; Role; Saliva; Salivary Glands; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Stream; Structure; Surface; Symptoms; Thermodynamic; Thermodynamics; Transmission; Trypanosoma; Trypanosome; Trypanosomiasis, South American; Vascular blood supply; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasorelaxation; Work; X-Radiation; X-Rays; Xrays; amino group; arginine-lysine; arginyllysine; blood supply; carboxylate; cardiac muscle; cleaved; design; designing; endothelial cell derived relaxing factor; ferriheme; ferroheme; gene product; heart muscle; hemoprotein; migration; mutant; necrocytosis; nitrophorin; nitrophorin 4; novel; prevent; preventing; protein function; protein structure; public health relevance; pulmonary; response; social role; stool; sucking; transmission process; vascular supply; vector",Nitric Oxide Interaction with Insect Nitrophorins," The saliva of the blood-sucking insect, Rhodnius prolixus, originally from the Amazon river basin, which carries the parasite Trypanasoma cruzi, the vector of Chagas' disease, contains a suite of heme proteins that we have named Nitrophorins (NPs). The NPs act as vasodilators, anti-platelet aggregation and anti-histaminic agents when injected into the victim. These properties aid the insect in obtaining an ample blood meal, and thus make more likely the transmission of the trypanosome from the insect feces to humans. The information obtained in the work proposed will allow understanding the roles of the N-terminus of the nitrophorins, the dynamics of these proteins and their response to both heme and ligand binding, and the roles of the charged protein residues of the NPs in protein function.",54826,MSFA,Macromolecular Structure and Function A Study Section,,14,375459,
7761674,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL056028-13,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,PATHOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"KURTZ, THEODORE W;",1886745;,5R01HL056028,01/01/1997,01/31/2013,"ATP biosynthesis (oxidative); Address; Affect; Amino Acid Substitution; Animal Model; Animal Models and Related Studies; Approaches to prevention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biochemical; Blood Pressure; Blood Pressure, High; Body Weight decreased; Candidate Disease Gene; Candidate Gene; Carbohydrates; Cardiac Diseases; Cardiac Disorders; Cardiovascular Diseases; Cell Line; Cell Lines, Strains; CellLine; Conditioning Therapy; Cytochrome Oxidase; Cytochrome-c Oxidase (Complex IV); D-Glucose; DNA; DNA, Mitochondrial; Deoxyribonucleic Acid; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dyslipidemias; Electron Transport Complex IV; Essential Hypertension; Exercise; Exercise, Physical; Exhibits; Experimental Models; Experimental Models, Other; Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Gene Expression; Gene variant; General Population; General Public; Genetic; Genetic Diversity; Genetic Models; Genetic Variation; Genome; Glucose; Haplotypes; Heart Diseases; Hereditary; Hour; Human; Human, General; Hypertension; Inbred SHR Rats; Inherited; Insulin Resistance; Intermediary Metabolism; Life Style Modification; Link; METBL; MODY; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediating; Metabolic; Metabolic Processes; Metabolic syndrome; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mitochondria; Mitochondrial DNA; Modeling; Models, Experimental; Models, Genetic; Molecular; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Norway; Nuclear; Obesity; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Pathogenesis; Patients; Phenotype; Play; Position; Positioning Attribute; Prevention; Prevention approach; Prevention therapy; Proteins; Rats, Inbred SHR; Rats, Norway; Rats, SHR; Rats, Spontaneously Hypertensive; Rattus norvegicus; Reporting; Risk; Risk Factors; Rodent; Rodentia; Rodentias; Role; T2D; T2DM; Techniques; Testing; Transgenic Model; Type 2 diabetes; Type II diabetes; Variant; Variation; Variation (Genetics); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weight Loss; Weight Reduction; adiposity; adult onset diabetes; allelic variant; base; behavior intervention; behavioral intervention; body weight loss; cardiovascular disorder; clinical practice; congenic; corpulence; corpulency; corpulentia; cultured cell line; cytochrome c oxidase; design; designing; diabetes; disease/disorder; fat metabolism; gene product; glucose metabolism; heart disorder; hemodynamics; hyperpiesia; hyperpiesis; hypertensive disease; idiopathic hypertension; insulin resistant; insulin sensitivity; interest; ketosis resistant diabetes; lipid metabolism; maturity onset diabetes; mitochondrial; mitochondrial genome; model organism; mtDNA; new approaches; novel; novel approaches; novel strategies; novel strategy; obese; obese people; obese person; obese population; primary hypertension; progenitor; social role; spontaneous hypertensive rat; wt-loss",New Experimental Models of Hypertension,,56028,HM,Hypertension and Microcirculation Study Section,,13,386250,
7756664,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL056069-11,,NHLBI:402500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"MENDELSOHN, MICHAEL E;",1871743;,5R01HL056069,01/15/1997,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 21+ years old; APOE [{C0003595}]; ATF; Accounting; Address; Adult; Age; Agonist; Animal Welfare; Animals; Apo-E; ApoE; ApoE knockout mouse; Apolipoprotein E; Area; Arterial Fatty Streak; Arterioles; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attention; Bibliography; Biology; Blood Pressure; Blood Vessels; Body Tissues; Breeding; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular system; Cardiovascular system (all sites); Cell Body; Cell-Death Protease; Cells; Change of Life, Female; Chemotherapy-Hormones/Steroids; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Conceptions; Confusion; Confusional State; Contractile Proteins; Controlled Study; Coronary; Country; Data; Deposit; Deposition; Disease; Disorder; Ecological impact; Editorial Comment; Editorial Comment (PT); Embryo; Embryonic; Endocrine Gland Secretion; Endocrine Therapy; Endothelial Cells; Environment; Environmental Impact; Equipment; Estrogen Receptors; Estrogen Therapy; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Ethics Committees, Research; Female; Figs; Figs - dietary; France; Funding; Gene Expression; Genes; Genomics; Hand; Hormonal Therapy; Hormone Replacement Rx; Hormone replacement therapy; Hormones; Human, Adult; IACUC; ICE-like protease; IRBs; Image; Impact, Environmental; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Isoforms; Jobs; Journals; Knock-out; Knockout; Knockout Mice; Laboratories; Leiomyocyte; Ligands; Magazine; Mammals, Mice; Medial; Mediating; Medical center; Menopause; Mental Confusion; Mesenteric; Mesenteric Arteries; Mesentery; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mutant Strains Mice; Myocytes, Smooth Muscle; Nature; New England; Northeastern United States; Null Mouse; Observational Study; Occupations; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Paper; Pathway interactions; Perimenopausal; Perimenopause; Peripheral; Phenotype; Population; Principal Investigator; Process; Production; Productivity; Professional Postions; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Isoforms; Publications; Published Comment; Publishing; Reading; Regulation; Relaxation; Reporting; Reports, Progress; Research; Research Ethics Committees; Research Institute; Research Personnel; Research Resources; Researchers; Resistance; Resources; Role; Scientific Publication; Series; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Societies; Streaks, Arterial Fatty; Structure of arteriole; Study models; Suggestion; Surgical; Surgical Interventions; Surgical Procedure; TAM; TXT; Tamoxifen; Testing; Text; Therapeutic Agents; Therapeutic Estrogen; Therapeutic Hormone; Time; Tissues; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell; Vascular, Heart; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Wild Type Mouse; Woman; Work; abstracting; activating transcription factor; adult human (21+); arteriole; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; blood vessel disorder; caspase; cell body (neuron); cerebrovascular; circulatory system; clinical investigation; constriction; cystein protease; cystein proteinase; cysteine endopeptidase; design; designing; disease/disorder; expiration; hormone therapy; human subject; imaging; in vivo; injury response; interest; knockout animal; macrophage; menopausal; mouse model; mouse mutant; neural cell body; neuronal cell body; new therapeutics; next generation therapeutics; non-genomic; nongenomic; novel therapeutics; pathway; programs; protective effect; resistant; response; response to injury; social role; soma; surgery; vascular; vascular smooth muscle cell proliferation; vertebrata; vulnerable plaque",Vascular Surgery - Estrogen and the Injury Response,,56069,SAT,"Surgery, Anesthesiology and Trauma Study Section",,11,402500,
7760982,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL056687-13,,NHLBI:376263;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"ROCKMAN, HOWARD A;",1886965;,5R01HL056687,08/01/1996,01/31/2011,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adrenaline; Adrenergic Receptor; Adrenoceptors; Antimorphic mutation; Cardiac; Cardiac infarction; Catecholamines; Cell Communication and Signaling; Cell Signaling; Chronic; Cyclic AMP-Dependent Protein Kinases; Deterioration; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; EC 2.7; EGFR; ERBB Protein; ERBB1; Epi; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epinephrine; Evaluation; Functional disorder; G-Proteins; GRK; GTP-Binding Proteins; GTP-Regulatory Proteins; Generalized Growth; Goals; Growth; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HER1; Heart; Heart failure; In Vitro; Individual; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Investigation; Kinases; Knockout Mice; Levarterenol; Levonorepinephrine; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular; Myocardial Infarct; Myocardial Infarction; Nerve Transmitter Substances; Neurotransmitters; Noradrenaline; Norepinephrine; Null Mouse; PKA; Peptides; Phenotype; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiopathology; Play; Pressure; Pressure- physical agent; Process; Protein Kinase A; Protein Phosphorylation; PtdIns; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Epinephrine; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Sympathins; System; System, LOINC Axis 4; Testing; Therapeutic Epinephrine; Tissue Growth; Trans-Activation (Genetics); Transactivation; Transforming Growth Factor alpha Receptor; Transgenic Mice; Transphosphorylases; adenoreceptor; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cAMP-Dependent Protein Kinases; cardiac failure; cardiac infarct; coronary attack; coronary infarct; coronary infarction; desensitization; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; heart attack; heart infarct; heart infarction; in vivo; mutant; novel; ontogeny; overexpression; pathophysiology; pressure; protein protein interaction; proto-oncogene protein c-erbB-1; receptor; response; social role",Mechanisms of Maladaptation in Heart Failure,,56687,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,13,376263,
7763811,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL057181-15,,NHLBI:466080;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAN FRANCISCO,UNITED STATES,,08,099992430,US,CA,94158,J. DAVID GLADSTONE INSTITUTES,"SRIVASTAVA, DEEPAK ;",1978469;,5R01HL057181,01/10/1997,01/31/2011,"21+ years old; Adult; Algorithms; Area; Cardiac; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac Myocytes; Cardiac defect; Cardiocyte; Cell Cycle; Cell Death; Cell Division Cycle; Computer Simulation; Computerized Models; Congenital Heart Defects; Data; Development; Elements; Embryo Development; Embryogenesis; Embryonic Development; Equilibrium; Genetic Translation; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; Heart myocyte; Human, Adult; In Vitro; Investigators; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mathematical Model Simulation; Mathematical Models and Simulations; Messenger RNA; Mice; Mice, Transgenic; Micro RNA; MicroRNAs; Models, Computer; Molecular; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Skeletal; Muscle, Voluntary; Myocytes; Myocytes, Cardiac; Organogenesis; Programs (PT); Programs [Publication Type]; Proteins; RNA, Messenger; Regulation; Regulatory Protein; Research Personnel; Researchers; Role; Simulation, Computer based; Skeletal Muscle Tissue; Skeletal muscle structure; Testing; Trans-Acting Factors; Trans-Activators; Transactivators; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transgenic Mice; Ventricular; Work; adult human (21+); balance; balance function; cardiogenesis; cardiomyocyte; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; dosage; gene product; genetic regulatory protein; heart defect; heart development; in silico; in vitro Model; in vivo; loss of function; mRNA; mRNA Translation; miRNA; myogenesis; necrocytosis; novel; overexpression; postnatal; premature; prenatal; programs; regulatory gene product; skeletal; skeletal muscle differentiation; social role; trans acting factor (genetic); unborn; virtual simulation",Cardiogenesis: Molecular Mechanisms,,57181,CDD,Cardiovascular Differentiation and Development Study Section,,15,466080,
7756578,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL058231-13,,NHLBI:368980;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,PHARMACOLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"BRAYDEN, JOSEPH ELLIOTT;",1922321;,5R01HL058231,04/01/1997,01/31/2011,"Agonist; Animals; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Arteries; Arterioles; Arts; Autoregulation; BK channels; Behavior; Big K channels; Blood Coagulation Factor IV; Blood Vessels; Blood capillaries; Blood flow; Body Tissues; Brain; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Channels, L-Type; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Caliber; Capillaries; Capillary; Capillary, Unspecified; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cations; Cations, Monovalent; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Cerebral Arteries; Cerebrospinal Fluid; Cerebrovascular Circulation; Cerebrum; Coagulation Factor IV; Communication; Coupling; Cytoplasmic Membrane; Data; Diameter; Dilator; Encephalon; Encephalons; Endothelial Cells; Endothelium; Endothelium-Dependent Relaxing Factors; Endothelium-Dependent Vasodilators; Endothelium-Derived Relaxant Factor; Endothelium-Derived Relaxing Factor; Event; Factor IV; Family; Fingerprint; G-kinase; Gene Expression Inhibitor; Gene Inactivation; Gene Silencing; Homeostasis; Hormonal; In Vitro; Intracellular Communication and Signaling; Investigators; Ion Channel; Ion Channels, Calcium; Ionic Channels; K element; Knockout Mice; L-Type Calcium Channels; L-Type VDCC; L-Type Voltage-Dependent Calcium Channels; Leiomyocyte; Life; Link; Long-Lasting Calcium Channels; MaxiK channels; Measurement; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Channels; Membrane Potentials; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Monovalent Cations; Muscle Cells; Muscle Cells, Mature; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes; Myocytes, Smooth Muscle; Nature; Nervous; Nervous System, Brain; Normal Tissue; Normal tissue morphology; Null Mouse; Oligonucleotides, Antisense; Organ System, Cardiovascular; PKC; Pathway interactions; Perfusion; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physiologic; Physiological; Physiological Homeostasis; Plasma Membrane; Play; Position; Positioning Attribute; Potassium; Pressure; Pressure- physical agent; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Kinase C; Receptor Activation; Receptor Protein; Receptors, Calcium Channel Blocker; Regulation; Research Personnel; Researchers; Resistance; Resting Potentials; Role; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Structure of arteriole; Structure of cerebral artery; System; System, LOINC Axis 4; TRP3 channel; TRP3 protein; TRPC3 channel; TRPC3 ion channel; TRPC3 protein; TRPV channel; Techniques; Tissues; Translating; Translatings; Transmembrane Potentials; VDCC; VR1 receptor; Vascular Endothelial Cell; Vascular constriction (function); Vascular, Heart; Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasomotor; Vasopressor Agents; Vasorelaxation; Voltage-Dependent Calcium Channels; Work; arteriole; base; biological signal transduction; blood flow measurement; brain circulation; cGMP-dependent protein kinase Ibeta; capillary; capsaicin receptor; cerebral artery; cerebral blood flow; cerebral circulation; cerebrocirculation; cerebrovascular; circulatory system; experiment; experimental research; experimental study; expression cloning; in vivo; knowledge base; language translation; large-conductance calcium-activated potassium channels; maxi-K channels; member; membrane structure; neural; novel; pathway; plasmalemma; pressure; programs; protein expression; receptor; relating to nervous system; research study; resistance mechanism; resistant; resistant mechanism; response; slowpoke protein; social role; spinal fluid; vanilloid receptor VR1; vanilloid receptors; vascular; vasopressor",Mechanisms of resistance artery contraction,,58231,VCMB,Vascular Cell and Molecular Biology Study Section,,13,368980,
7758226,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL058883-12,,NHLBI:486216;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"GETZOFF, ELIZABETH D;",1887264;,5R01HL058883,08/15/1997,01/31/2012,"5,6,7,8-tetrahydrobiopterin; Active Sites; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Affect; Affinity; Apoplexy; Arginine; Arginine, L-Isomer; Arthritis; BH4; BP control; BPH4; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Biological; Biological Function; Biological Process; Biology; C-terminal; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cancers; Catalysis; Caveolin Proteins; Caveolins; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chromatography, Molecular Sieve; Coenzyme II; Combining Site; Complement; Complement Proteins; Complex; Crystallographies; Crystallography; Cytotoxic agent; Cytotoxic drug; Cytotoxin; DNA Molecular Biology; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dehydrogenases; Deuterium; Diabetes Mellitus; Digestion; Disulfide Linkage; Docking; EC 1.14.13.39; EDRF Synthase; Electron Transport; Electrons; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Equilibrium; FMN; FMN Oxidoreductase; FMN reductase; FRET; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Flavin Mononucleotide; Flavin Mononucleotide Reductase; Fluorescence; Fluorescence Resonance Energy Transfer; Genetics-Mutagenesis; Goals; Guanylyl Cyclase-Activating Factor Synthase; H element; H2 isotope; H4B; H4biopterin; Heme; Heme b; Hydrogen; Inflammatory; Intracellular Communication and Signaling; Ions; Isoenzymes; Isoforms; Isozymes; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Length; Literature; Long-Term Potentiation; Malignant Neoplasms; Malignant Tumor; Mass Spectrum; Mass Spectrum Analysis; Measurement; Medical; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Biology; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Sieve Chromatography; Mononitrogen Monoxide; Motion; Movement; Mutagenesis; NAD phosphate; NAD(H) phosphate; NAD(P)H Dehydrogenase (FMN); NAD(P)H dehydrogenase; NAD(P)H-FMN Oxidoreductase; NAD(P)H-Flavin Oxidoreductase; NADH phosphate; NADH-FMN Oxidoreductase; NADH-Flavin Oxidoreductase; NADP; NADPH; NADPH-Diaphorase; NADPH-Flavin Reductase; NO Synthase; Negative Beta Particle; Negatrons; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuronal Transmission; Neurons; Nicotinamide-Adenine Dinucleotide Phosphate; Nitric Oxide; Nitric Oxide Signaling Pathway; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Outcome; Oxidation-Reduction; Oxidoreductase; Oxygenases; Parasites; Peptides; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Photometry/Spectrum Analysis, Mass; Platelet aggregation; Production; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Phosphorylation; Proteins; Protoheme; Protoheme IX; Pterins; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Redox; Reductases; Regulation; Research; Resolution; Riboflavin 5'-(dihydrogen phosphate); Riboflavin 5'-Monophosphate; Riboflavin 5'-Phosphate; Riboflavin Mononucleotide; Roentgen Rays; Sepsis; Septic Shock; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sites, Active; Size Exclusion Chromatography; Specificity; Spectrometry, Mass; Spectroscopy; Spectroscopy, Mass; Spectrum Analyses; Spectrum Analyses, Mass; Spectrum Analysis; Spectrum Analysis, Mass; Stroke; Structural Biochemistry; Structural Chemistry; Structure; Surface Plasmon Resonance; System; System, LOINC Axis 4; THBP; Tail; Techniques; Testing; Therapeutic; Tripcellim; Triphosphopyridine Nucleotide; Trypsin; Tumor Cell; Vascular Accident, Brain; X-Radiation; X-Rays; Xrays; arthritic; balance; balance function; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; bloodstream infection; body movement; brain attack; cerebral vascular accident; cofactor; design; designing; diabetes; dimer; electron transfer; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; ferroheme; flexibility; gene product; improved; inhibitor; inhibitor/antagonist; light scattering; malignancy; mutant; neoplasm/cancer; neoplastic cell; neurodegenerative illness; neuronal; neurotransmission; oxidation reduction reaction; research study; stroke; tetrahydro-6-biopterin; tetrahydrobiopterin",Structural Metallobiochemistry of Nitric Oxide Synthases,,58883,MSFA,Macromolecular Structure and Function A Study Section,,12,486216,
7760169,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL059655-12,,NHLBI:372375;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,PATHOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SHADEL, GERALD S;",2097823;,5R01HL059655,09/30/1997,01/31/2012,"ATP biosynthesis (oxidative); Active Oxygen; Address; Aging; Animal Welfare; Bibliography; Body Tissues; Brain; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Death; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; CellLine; Cells; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; DNA, Mitochondrial; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Defect; Disease; Disorder; EC 2.7.7.6; Ecological impact; Editorial Comment; Editorial Comment (PT); Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Figs; Figs - dietary; Gene Expression; Gene Transcription; Genetic Transcription; Goals; HeLa; Heart; Heart Diseases; Hela Cells; Housing; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Mammalian Cell; Man (Taxonomy); Man, Modern; Mitochondria; Mitochondria RNA; Mitochondrial DNA; Mitochondrial RNA; Muscle, Skeletal; Muscle, Voluntary; Nature; Nervous System, Brain; Nuclear; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleus; Organelles; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxidative Stress; Oxygen Radicals; Pathology; Polymerase; Principal Investigator; Pro-Oxidants; Process; Production; Programs (PT); Programs [Publication Type]; Proteins; Published Comment; RNA Expression; RNA Polymerases; Reactive Oxygen Species; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Tissues; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Translations; Up-Regulation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; age dependent; age related; biological signal transduction; cultured cell line; disease/disorder; expiration; gene product; heart disorder; human disease; human subject; mitochondrial; mitochondrial dysfunction; mtDNA; mtRNA; necrocytosis; overexpression; programs; response; senescent; transcription factor; vertebrata",Nuclear Control of Mitochondrial Gene Expression,,59655,MGB,Molecular Genetics B Study Section,,12,372375,
7754387,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL059873-12,,NHLBI:430401;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,NEUROSCIENCES,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"JACKSON, F. ROB ;",1873474;,5R01HL059873,08/01/1997,01/31/2012,"Affect; Algae, Blue-Green; Assay; Award; Band Shift Mobility Assay; Bandshift Mobility Assay; Behavior; Behavior Control; Behavioral; Behavioral Assay; Behavioral Manipulation; Binding; Binding (Molecular Function); Binding Sites; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Blue-Green Bacteria; CCAP; CCP I; Casein Kinase TS; Casein Kinase-2; Causality; Cell Function; Cell Nucleus; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Circadian Rhythms; Combining Site; Complex; Consensus Sequence; ConsensusSequence; Coupled; Cyanobacterium; Cyanophyceae; Cyanophyta; Cyclicity; Cytoplasm; DNA Alteration; DNA mutation; Defect; Disease; Disorder; Diurnal Rhythm; Drosophila; Drosophila FMR1 protein; Drosophila genus; Electrophoretic Mobility Shift Assay; Elements; Escalante syndrome; Etiology; Exhibits; Experimental Organism; FMR1 protein, Drosophila; FXR protein, Drosophila; Flies; Fragile X; Fragile X Syndrome; Fruit Fly, Drosophila; Funding; Gene Alteration; Gene Mutation; Gene Products, RNA; Gene Transcription; Genes; Genetic; Genetic Models; Genetic Techniques; Genetic Transcription; Genetic mutation; Genetics, in situ Hybridization; Glean; Grant; Human; Human, General; Immune Precipitation; Immunoprecipitation; Import, Nuclear; In Situ Hybridization; In element; Indium; Individual; Insecta; Insects; Invertebrates, Insects; Investigation; Jet Lag; Jet Lag Syndrome; Jetlag; Jetlag Syndrome; Katacalcin (human); Laboratory Organism; Lead; Locomotor Activity; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Mediating; Methods; Methods and Techniques; Methods, Other; Mobility Shift Assay; Models, Genetic; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Motor Activity; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Nuclear Import; Nucleus; Nyctohemeral Rhythm; Organism; Organism-Level Process; Organismal Process; Output; Pace Stimulators; Pacemakers; Pathway interactions; Pb element; Periodicity; Phase; Phenotype; Physiologic Processes; Physiological Processes; Physiology; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Procedures; Progress Reports; Protein Kinase CK2; Protein Kinase CKII; Proteins; Protocol; Protocols documentation; Publishing; Quelling; RNA; RNA Binding; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA Stability; RNA, Non-Polyadenylated; RNA-Binding Proteins; RNAi; Reactive Site; Renpenning syndrome 2; Reports, Progress; Rhythmicity; Ribonucleic Acid; Ribosomal Protein S6 Kinase; Role; S6 Kinase; S6-H4 Kinase; Sequence Alteration; Sequence-Specific Posttranscriptional Gene Silencing; Site; Sleep; Stimulators, Electrical, Pace; Structure; Subcellular Process; Surface Plasmon Resonance; System; System, LOINC Axis 4; Technics, Genetic; Techniques; Testing; Time; Time Zone Change Syndrome; Time Zone Syndrome; Transcription; Transcription, Genetic; Transgenes; Twenty-Four Hour Rhythm; UTRs; United States National Institutes of Health; Untranslated Regions; Work; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; base; behavioral control; calcitonin carboxyl-terminal flanking peptide; casein kinase II; cell type; circadian; circadian clock; circadian pacemaker; circadian process; cross-link; crosslink; dFMR1 protein, Drosophila; dFXR protein, Drosophila; dFmr1 protein; dFmrp; daily biorhythm; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; diurnal variation; experiment; experimental research; experimental study; fly; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; fruit fly; gel shift assay; gene function; gene product; hCCAP; heavy metal Pb; heavy metal lead; human CCAP; in situ Hybridization Staining Method; in vivo; insight; katacalcin; living system; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; mar(X) syndrome; marker X syndrome; mental retardation-macroorchidism syndrome; mutant; neural; neuronal; novel; overexpression; pathway; peptide (aspartic acid-asparagine); preprocalcitonin carboxyl-terminal region peptide; protein function; relating to nervous system; research study; response; social role; synapse function; synaptic function",Studies of a Neural Pacemaker Output Pathway,,59873,ZRG1,Special Emphasis Panel,,12,430401,
7803687,R01,HL,5,,03/01/2010,02/28/2011,PA-07-070,5R01HL060742-10,,NHLBI:474750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"RUF, WOLFRAM ;",1866918;,5R01HL060742,07/01/1998,02/28/2013,"APC receptor; Address; Angiogenic Switch; Antibodies; Attenuated; Bleeding; Blood Coagulation Factor III; Blood Coagulation Factor VII, Activated; Breast Cancer Cell; Breast Cancer Model; CD142 Antigens; CF2R; Cancer of Breast; Cancers; Carcinoma; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell model; Cell surface; Cellular Migration; Cellular model; Clinic; Clinical Trials; Clinical Trials, Unspecified; Clotting; Coagulants; Coagulation; Coagulation Factor III; Coagulation Factor VIIa; Coagulation Process; Coagulin; Complex; Cytoplasmic Domain; Cytoplasmic Tail; Data; Development; Epidemiology; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Esteroproteases; Event; Extracellular Matrix, Integrins; F2R; F2R gene; Factor III; Factor VII, Activated; Factor VIIa; Funding; Genetic; Genetic Models; Glomerular Procoagulant Activity; Goals; Hemorrhage; Human; Human Breast Cancer Cell; Human, General; Integrins; Interruption; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Ligand Binding; Link; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Models, Genetic; Motility; Motility, Cellular; Murine; Mus; Neoplasm Metastasis; Normal Cell; Oncogenic; Operation; Operative Procedures; Operative Surgical Procedures; PAR1; Pathway interactions; Peptidases; Peptide Hydrolases; Pre-Clinical Model; Preclinical Models; Proteases; Proteinases; Proteolytic Enzymes; Prothrombinase; Publishing; Receptor Protein; Receptor Signaling; Relative; Relative (related person); Role; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Surgical; Surgical Interventions; Surgical Procedure; Testing; Thrombase; Thrombin; Thromboplastin; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Translations; Tumor Cell; Tumor Cell Migration; Urothromboplastin; Work; Xenograft Model; activated protein C receptor; angiogenesis; base; biological signal transduction; blood loss; cancer cell; cancer metastasis; cancer progression; cell motility; clinical investigation; cytokine; endothelial cell protein C receptor; epithelial carcinoma; experiment; experimental research; experimental study; fibrinogenase; in vivo; inhibitor; inhibitor/antagonist; insight; interventional strategy; knock-down; malignancy; malignant breast neoplasm; mammary cancer model; mammary tumor model; mouse model; neoplasm progression; neoplasm/cancer; neoplastic cell; neoplastic progression; novel; paracrine; pathway; public health relevance; receptor; research study; social role; surgery; tool; tumor; tumor growth; tumor progression; tumorigenic",Functional Cooperation of Tissue Factor and Integrins," Relevance The role of coagulation activation and cancer progression is well documented by epidemiology and clinical trials. This application addresses a novel pathway by which coagulation signaling promotes tumor progression. Because a prototypic inhibitor of this pathway is effective to attenuate tumor growth in preclinical models, the proposed basic mechanistic studies facilitate a rational translation of this novel concept into the clinic.",60742,ZRG1,Special Emphasis Panel,,10,474750,
7748915,R01,HL,5,,01/15/2010,12/31/2010,PA-07-070,5R01HL061298-11,,NHLBI:402500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"KARAS, RICHARD H;",1880706;,5R01HL061298,01/01/1999,12/31/2012,"ATF; Animal Welfare; Assay; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biology; Blood Pressure, High; Blood Vessels; CNOS; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chemotherapy-Hormones/Steroids; Co-Immunoprecipitations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Consensus; Constitutive NOS; Country; Cytoplasmic Membrane; Data; Development; EC 2.7; ECNOS; ENOS; Ecological impact; Editorial Comment; Editorial Comment (PT); Endocrine Gland Secretion; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Environment; Environmental Impact; Equipment; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethics Committees, Research; Event; Family member; Figs; Figs - dietary; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Genomics; Grant; HOSP; Hormones; Hospitals; Hypertension; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Kinases; Laboratories; Left; Ligands; Literature; Mammals, Mice; Manuscripts; Mediating; Methods; Mice; Mice, Transgenic; Mining; Minings; Molecular; Molecular Interaction; Murine; Mus; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide Synthase 3; Nuclear Hormone Receptor Superfamily; Nuclear Hormone Receptors; Organ System, Cardiovascular; Pathway interactions; Peptide Domain; Peptides; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiologic; Physiological; Physiology; Plasma Membrane; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Domains; Protein Phosphorylation; Proteins; Published Comment; RIP; RIP Protein Kinase; RIPK1; RIPK1 protein, human; RNA Expression; RNA, Small Interfering; Receptor Protein; Receptor Signaling; Receptor-Interacting Protein; Receptor-Interacting Serine/Threonine Kinase 1; Regulation; Reporter; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Response Elements; Role; Scaffolding Protein; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Suggestion; Tail; Tertiary Protein Structure; Testing; Therapeutic Agents; Therapeutic Estrogen; Therapeutic Hormone; Time; Transcription; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Regulation; Transcription, Genetic; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Transfection; Transgenic Mice; Transphosphorylases; Up-Regulation; Vascular Endothelial Cell; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular System; Vascular, Heart; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; activating transcription factor; activator protein 3; base; biological signal transduction; circulatory system; clinical relevance; clinically relevant; cohort; eNOS enzyme; endothelial constitutive nitric oxide synthase; expiration; gene product; human NOS3 protein; human RIPK1 protein; human subject; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; insight; interest; knock-down; member; mutant; new therapeutics; next generation therapeutics; non-genomic; nongenomic; novel; novel therapeutics; pathway; plasmalemma; prevent; preventing; programs; protein complex; receptor; response; siRNA; social role; vascular; vertebrata",Vascular Estrogen Receptor Signaling Pathways,,61298,VCMB,Vascular Cell and Molecular Biology Study Section,,11,402500,
7805617,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL061656-12,,NHLBI:510600;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PATTERSON, WINSTON C;",1882671;,5R01HL061656,04/15/2009,01/31/2013,"21+ years old; ATPase, Actin-Activated; Address; Adenosine Triphosphatase, Myosin; Adhesions; Adopted; Adult; Angioblast; Arts; Autoregulation; BMP4; BMP6; BMP6 gene; Binding Proteins; Biological; Birth; Blood Diseases; Blood Vessels; Blood monocyte; Body Tissues; Bone Morphogenetic Proteins; Bronchioles; Bronchiolus; Candidate Disease Gene; Candidate Gene; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Cues; Data; Defect; Development; Differentiation and Growth; Disease; Disorder; Dysfunction; ES cell; Embryo Development; Embryogenesis; Embryonic Development; Endocytosis; Endothelial Cells; Endothelium; Endothelium, Vascular; Event; Functional disorder; Funding; GFAC; Gene Delivery; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Generalized Growth; Genes; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Health; Hematologic Diseases; Hematological Disease; Hematological Disorder; Hemostasis; Hemostatic function; Homeostasis; Human, Adult; INFLM; Inflammation; Inflammatory; Inflammatory Response; Injury; Intracellular Communication and Signaling; Ischemia; Knowledge; Ligand Binding Protein; Lung; Mammals, Mice; Marrow monocyte; Mediating; Mice; Molecular; Molecular Biology Techniques; Morphogenesis; Mother Cells; Motor; Murine; Mus; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; Natural regeneration; Organ System, Cardiovascular; Parturition; Pathologic; Pathologic Processes; Pathological Processes; Pathology; Pathway interactions; Pattern Formation; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Play; Process; Profilings, Gene Expression; Progenitor Cells; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding; Proteins; Regeneration; Regulation; Reporting; Respiratory System, Lung; Role; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Molecule; Stem cells; Subcellular Process; Testing; Tissue Growth; Tissues; Transcript Expression Analyses; Transcript Expression Analysis; VG1-Related Sequence; VGR1 Gene; Vascular Diseases; Vascular Disorder; Vascular Endothelium; Vascular System; Vascular, Heart; Vasomotor; adult human (21+); angiogenesis; base; biological signal transduction; blood disorder; blood vessel disorder; cell type; circulatory system; disease/disorder; embryonic stem cell; experiment; experimental research; experimental study; gene product; in vivo; interest; member; migration; monocyte; myosin ATP phosphohydrolase (actin translocating); novel; ontogeny; pathophysiology; pathway; pleiotropism; pleiotropy; programs; public health relevance; pulmonary; regenerate; research study; response; social role; stem cell differentiation; stem cell of embryonic origin; transcription factor; vascular; vascular inflammation; vasculogenesis",Signaling in Endothelial Growth and Angiogenesis,,61656,ZRG1,Special Emphasis Panel,,12,510600,
7750537,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL063313-10,,NHLBI:382500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,IRVINE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"LONGHURST, JOHN C;",1891410;,5R01HL063313,09/20/2000,12/31/2013,"1-phenylbiguanide; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-; 5-HT; 5-Hydroxytryptamine; 5HT; Abdomen; Abdominal; Acupoints; Acupuncture Points; Acupuncture procedure; Adverse effects; Afferent Pathways; Aminalon; Aminalone; Aminobutyric Acids; Anhydroglucochloral; Animals; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Apoplexy; Arrhythmia; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; Bradycardia; Butanoic Acids; Butanoic acid, 4-amino-; Butyric Acids; C Fiber; Cardiac; Cardiac Arrhythmia; Cardiac Failure Congestive; Cardiopulmonary; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cats; Cell Nucleus; Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemoreceptors; Chest; Ching Lo; Chloralose; Chronotropism, Cardiac; Chronotropisms, Cardiac; Clinical; Common Rat Strains; Communities; Complementary and alternative medicine; Congestive Heart Failure; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cutaneous; Data; Depressed mood; Depression; Disease; Disorder; Domestic Cats; Dorsal; Dorsal Horn of the Spinal Cord; Dynorphins; Electroacupuncture; Endorphins; Enkephalins; Enteramine; Fainting; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fiber; Fibular Nerve; Figs; Figs - dietary; Frequencies (time pattern); Frequency; Funding; GABA; Gall Bladder; Gallbladder; Gallbladder / Biliar; Gallbladder/Biliary system; Gastrointestinal Tract, Gall Bladder; Glucochloral; Glucochloralose; Glutamates; Grant; Heart; Heart Arrhythmias; Heart Decompensation; Heart Failure, Congestive; Heart Rate; Hippophaine; Hypertension; Hypotension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Hypothalamic structure; Hypothalamus; Imagery; Incidence; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Jing Luo; Jingluo; Ketamine; L-Glutamate; Mammals, Cats; Mammals, Rats; Manuals; Medial; Mediating; Medical; Medulla Spinalis; Mental Depression; Meridians; Mesencephalon; Methods and Techniques; Methods, Other; Mid-brain; Midbrain; Midbrain structure; Modality; Modeling; Molecular; Myocardial Ischemia; N-phenyl-N'-guanylguanidine; NCCAM; Names; National Center for Complementary and Alternative Medicine; Nausea and Vomiting; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Neurotransmitters; Nucleus; Nucleus Ambiguus; Nucleus Tractus Solitarii; Nucleus solitarius; Opioid; Opioid Receptor; Organ System, Cardiovascular; Pain; Painful; Pathway interactions; Patients; Peptide Receptor; Pericardial; Pericardial body location; Peripheral; Peroneal Nerve; Physicians; Radial Nerve; Rat; Rattus; Receptor Protein; Receptors, Opiate; Reflex; Reflex action; Regulation; Relative; Relative (related person); Research; Risk Factors; Role; Serotonin; Site; Skin; Solitary Nucleus; Specificity; Spinal; Spinal Cord; Spinal Cord Column; Spinal cord posterior horn; Stomach; Stroke; Structure of common peroneal nerve; Structure of nucleus ambiguus; Structure of radial nerve; Syncope; System; System, LOINC Axis 4; TXT; Techniques; Text; Therapeutic; Thorace; Thoracic; Thoracic Portion of Spinal Cord; Thoracic Spinal Cord; Thoracic spinal cord structure; Thorax; Treatment Side Effects; United States; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vascular, Heart; Visceral; Visualization; Work; Xylaxine; Xylazine; acupuncture; alpha-Chloralose; alpha-D-Glucofuranose, 1,2-O-(2,2,2-trichloroethylidene)-, (R)-; brain attack; cardiovascular disorder; cardiovascular function; cerebral vascular accident; chronotropic; circulatory system; clinical relevance; clinically relevant; depressed; design; designing; disease/disorder; dorsal horn; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; gastric; heart ischemia; hyperpiesia; hyperpiesis; hypertensive disease; hypothalamic; imidodicarbonimidic diamide, N-phenyl-; improved; interest; myocardial ischemia/hypoxia; myocardium ischemia; neural; neural mechanism; neuromechanism; neuronal; nociceptin; nucleus ambiguus; orphanin FQ; pathway; peroneal nerve; phenyl biguanide; phenyl diguanide; phenylbiguanide; phenyldiguanide; public health relevance; raphe nuclei; receptor; relating to nervous system; research study; response; sadness; side effect; social role; solitary tract nucleus; stroke; therapy adverse effect; treatment adverse effect",Mechanims of CNS Autonomic Regulation by EA," Project Narrative Blood pressure abnormalities are major risk factors for coronary artery disease, stroke, congestive heart failure and syncope. However, both hypertension and hypotension are poorly treated because many patients often are unwilling to use standard medical therapy. Today in the US, patients increasingly are lookingforintegrativetherapiesthataremoreacceptablefortreatmentoftheirbloodpressureabnormality. Althoughacupuncturemaybeaviableinexpensivealternativethathasaverylowincidenceofsideeffects, physicians generally are reluctant to recommend this therapy because little data are available on its efficacy and particularly on its mechanisms of action. The current application will provide important new information on both efficacy and mechanism of action in acupuncture treatment of either elevated or low blood pressure.",63313,ZRG1,Special Emphasis Panel,,10,382500,
7765486,R01,HL,5,,03/01/2010,02/28/2011,PA-07-070,5R01HL064793-11,,NHLBI:413750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,PHARMACOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"SESSA, WILLIAM C.;",1866896;,5R01HL064793,03/07/2000,02/28/2012,"AMP Kinase; APOE [{C0003595}]; ATP-AMP Phosphotransferase; ATP-AMP Transphosphorylase; ATP-protein phosphotransferase; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenylokinase; Apo-E; ApoE; Apolipoprotein E; Apoptosis; Apoptosis Pathway; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autoregulation; Blood Pressure, High; Blood Vessels; Blood flow; Blood monocyte; Bone Marrow Transplant; Bone Marrow Transplantation; Bovine Species; Breeding; CAV1; CNOS; Cardiac Diseases; Cardiac Disorders; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cattle; Caveolae Protein, 22kD; Caveolin 1, Caveolae Protein, 22kD; Cell Death, Programmed; Cell Survival; Cell Viability; Cells; Constitutive NOS; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cyclic AMP-Dependent Protein Kinases; D Aspartate; Diet; Drugs; Dysfunction; EC 2.7; ECNOS; ENOS; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Relaxing Factor; Functional disorder; Grafting, Bone Marrow; Grant; Heart Diseases; Hindlimb; Homeostasis; Human; Human, General; Hypertension; In Vitro; Injury; Ischemia; Kinases; L-Serine; Lesion; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Marrow monocyte; Medication; Mice; Modeling; Molecular; Mononitrogen Monoxide; Murine; Mus; Myokinase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nitric Oxide; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; PKA; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Physiopathology; Production; Protein Kinase; Protein Kinase A; Protein Phosphorylation; Public Health; QOL; Quality of life; Regional Blood Flow; Regulation; Relaxation; Research; Research Support; Role; Serine; Serine Phosphorylation Site; Site; Testing; Transphosphorylases; VEGFs; VIP21; VIP21 protein; Vascular Endothelial Growth Factors; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Vegf; Work; Wound Healing; Wound Repair; adenylate kinase; angiogenesis; atherogenesis; atheromatosis; atherosclerotic vascular disease; bovid; bovine; cAMP-Dependent Protein Kinases; cardiovascular disorder; caveolin; caveolin 1; circulatory system; congenic; cow; drug/agent; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; feeding; gain of function mutation; glycogen synthase a kinase; heart disorder; human NOS3 protein; hydroxyalkyl protein kinase; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vitro testing; in vivo; insight; macrophage; migration; monocyte; neointima formation; neointimal thickening; pathophysiology; phosphorylase b kinase kinase; postnatal; protein protein interaction; public health medicine (field); research study; response; social role; tissue repair; vascular; vascular inflammation; vesicular integral membrane protein 21 kDa",Phosphorylation and Endothelial Nitric Oxide Production,,64793,VCMB,Vascular Cell and Molecular Biology Study Section,,11,413750,
7760649,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL065567-08,,NHLBI:344546;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BROSIUS, FRANK C;",1869574;,5R01HL065567,07/01/2000,01/31/2012,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT Receptors; 5-Hydroxytryptamine; 5-Hydroxytryptamine Receptors; 5HT; Affect; Agonist; Animal Model; Animal Models and Related Studies; Animals; Arteries; Blood Coagulation Factor IV; Blood Pressure; Blood Pressure, High; Blood Vessels; Body Tissues; CAV1; Ca++ element; Calcium; Calponin Phosphatase; Caveolae; Caveolae Protein, 22kD; Caveolas; Caveolin 1, Caveolae Protein, 22kD; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Characteristics; Chronic; Coagulation Factor IV; Coupled; D-Glucose; Data; Development; Dextrose; Enteramine; Factor IV; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; GLUT4; GLUT4 gene; GPCR Signaling; Glucose; Hippophaine; Human; Human, General; Humulin R; Hypertension; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Intermediary Metabolism; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Investigators; Knock-out; Knockout; Knockout Mice; Lead; Leiomyocyte; Lipid Rafts, Cell Membrane; METBL; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Membrane Microdomains; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Murine; Mus; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Novolin R; Null Mouse; Pathway interactions; Patients; Pb element; Phenotype; Play; Protein Trafficking; Receptor Protein; Research Personnel; Researchers; Rho-associated kinase; Rho-kinase; Rodent; Rodentia; Rodentias; Role; Serotonin; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Myosins; Smooth Muscle Tissue Cell; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Study Section; Testing; Tissues; Traffickings, Protein; Transgenic Mice; Transgenic Organisms; VIP21; VIP21 protein; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; biological signal transduction; caveolin; caveolin 1; glucose transport; glucose uptake; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; insulin resistant; interventional strategy; knockout animal; lipid raft; model organism; morphometry; myosin phosphatase; pathway; prevent; preventing; protective effect; protein transport; receptor; response; rho; serotonin receptor; social role; sugar; transgenic; vascular; vesicular integral membrane protein 21 kDa",GLUT4 Determines Vascular Responses in Hypertension,,65567,HM,Hypertension and Microcirculation Study Section,,8,344546,
7763878,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL065680-08,,NHLBI:345375;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"HANCK, DOROTHY A;",1922388;,5R01HL065680,09/30/2000,01/31/2011,"1,4-dihydropyridine; 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, P-oxide, monohydrochloride; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, P-oxide, hydrochloride; Action Potentials; Adverse effects; Affect; Affinity; Amlodipine; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antigenic Determinants; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Apoplexy; Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-; Binding; Binding (Molecular Function); Binding Determinants; Blood Pressure; Blood Pressure, High; Blood Pressure, Low; COX2 inhibitor; CP33; CP34; CYP3; CYP3A; CYP3A13; CYP3A3; CYP3A4; CYP3A4 gene; CYPIIIA4; Cahill May Roberts brand of rofecoxib; Calcium Antagonists, Exogenous; Calcium Blockaders, Exogenous; Calcium Channel Binding; Calcium Channel Blockers; Calcium Channel Blocking Drugs; Calcium Channels, L-Type; Calcium Channels, T-Type; Calcium Inhibitors, Exogenous; Cardiac; Cardiac Diseases; Cardiac Disorders; Cause of Death; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Charge; Clinical; Clinical Trials; Clinical Trials, Unspecified; Coronary Disease; Coronary heart disease; Country; Coxibs; Cyclooxygenase 2 Inhibitors; Dependence; Dihydropyridines; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Interactions; Drug Targeting; Drug Targetings; Drugs; Electrophysiology; Electrophysiology (science); Enzymes; Epitopes; Fluorescence; Generations; Genetics-Mutagenesis; Goals; Grant; HLP; Heart; Heart Diseases; Hypertension; Hypotension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Ion Channel; Ionic Channels; Iproveratril; Kinetic; Kinetics; L-Type Calcium Channels; L-Type VDCC; L-Type Voltage-Dependent Calcium Channels; Laboratories; Link; Location; Long-Lasting Calcium Channels; MSD brand of rofecoxib; Marketing; Mechanics; Medication; Membrane Channels; Membrane Potentials; Merck Frosst brand of rofecoxib; Merck Sharp & Dhome brand of rofecoxib; Merck brand of rofecoxib; Methods and Techniques; Methods, Other; Mibefradil; Modeling; Models, Molecular; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Models; Molecular Stereochemistry; Movement; Muscle, Involuntary; Muscle, Smooth; Mutagenesis; NF-25; Neurophysiology / Electrophysiology; Nucleic Acid Biochemistry, Molecular Modeling; P450-PCN1; P450C3; P450PCN1; Paroxysmal Atrial Tachycardia; Pharmaceutic Preparations; Pharmaceutical Preparations; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein/Amino Acid Biochemistry, Molecular Modeling; Reporting; Resting Potentials; Risk; Rofecoxib; Site; Smooth muscle (tissue); Specificity; Stroke; T-Type Calcium Channels; T-Type VDCC; T-Type Voltage-Dependent Calcium Channels; Techniques; Testing; Therapeutic Agents; Transient-Type Calcium Channels; Transmembrane Potentials; Treatment Side Effects; V (voltage); Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Vascular System; Verapamil; Vioxx; Vioxx Dolor; base; body movement; brain attack; calcium antagonist; cerebral vascular accident; clinical investigation; comparative; computerized; conformation; conformational state; coronary disorder; cross reactivity; dihydropyridine; disease/disorder; drug/agent; effective therapy; efonidipine; experience; heart disorder; hyperpiesia; hyperpiesis; hypertensive disease; molecular modeling; phenylalkylamine; programs; prototype; side effect; stroke; therapy adverse effect; treatment adverse effect; voltage",Cardiac Channels: Targets of Drugs that Affect Kinetics,,65680,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,8,345375,
7763813,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL066231-08,,NHLBI:365000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLESTON,UNITED STATES,ANATOMY/CELL BIOLOGY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"MJAATVEDT, COREY H;",6491215;,5R01HL066231,12/01/2000,01/31/2013,"21+ years old; 3-D structure; 3-dimensional structure; 3D structure; Address; Adult; Affect; Alternate Splicing; Alternative Splicing; Animal Welfare; Be element; Be++ element; Beryllium; Bibliography; Bioassay, in vitro; Birth Defects; Body Tissues; Breeding; Cardiac; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cell Communication and Signaling; Cell Density; Cell Signaling; Cell-Extracellular Matrix; Cells; Childhood; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Heart Defects; Congenital Malformation; Congenital malformation of cardiac septum; Country; Critiques; Data; Defect; Density, Cell; Development; Developmental Biology; ECM; EGF; EGF gene; EGFR; ERBB Protein; ERBB1; Ecological impact; Embryo; Embryonic; Embryonic Heart; Endocardium; Environment; Environmental Impact; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Equipment; Ethics Committees, Research; Event; Extracellular Matrix; FLR; Failure (biologic function); Funding; Gene Proteins; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth; HER1; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; Heart Septal Defects; Human, Adult; Hyaluronan; IACUC; IRBs; Image; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Knockout Mice; Lap18 protein; Length; Live Birth; Mammals, Mice; Manuscripts; Mediating; Mesenchymal; Mesenchymas; Mesenchyme; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Genetic Abnormality; Morphogenesis; Morphology; Murine; Mus; Mutation; Myocardial; Null Mouse; Phenotype; Play; Preparation; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Cleavage; Protein Gene Products; Proteins; Proteoglycan; Proteolysis; Proteome; Proteomics; Publishing; Pulmonary Artery; Pulmonary artery structure; RNA Splicing; RNA Splicing, Alternative; RNA, Messenger; Reagent; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Role; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Staging; Techniques; Testing; Tissue Growth; Tissues; Transforming Growth Factor alpha Receptor; Tube; URG; Ventricular; Vertebrate Animals; Vertebrates; Work; abstracting; adult human (21+); biological signal transduction; c-erbB-1; c-erbB-1 Protein; cardiac septal defect; cardiac septal deformity; cardiac septum defect; cardiac septum deformity; cardiogenesis; clinical relevance; clinically relevant; congenital cardiac septum defect; congenital heart septum defect; congenital malformation of septum; design; designing; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; expiration; failure; gene product; genome mutation; heart defect; heart development; heart septal deformity; heart septum defects; heart septum deformity; human subject; imaging; in vitro Bioassay; in vivo; in vivo Model; insight; leukemia-associated phosphoprotein p18; mRNA; metablastin; mouse model; mutant; nestin; nestin protein; novel; oncoprotein 18; ontogeny; pediatric; phosphoprotein p18; phosphoprotein p19; programs; prosolin; protein expression; proto-oncogene protein c-erbB-1; receptor; research study; septal defect; septum defect; social role; stathmin; three dimensional structure; vector; versican; vertebrata",CSPG2 GENE AND CARDIAC OUTLET MORPHOGENESIS,,66231,CDD,Cardiovascular Differentiation and Development Study Section,,8,365000,
7767702,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL067748-07,,NHLBI:253750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,BIOMEDICAL ENGINEERING,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"FAST, VLADIMIR G;",6412057;,5R01HL067748,08/10/2001,01/31/2013,"Action Potentials; Address; Affect; Affinity; Arrhythmia; Blood Coagulation Factor IV; Body Tissues; Ca++ element; Calcium; Cardiac; Cardiac Arrhythmia; Cardioversion; Catecholamines; Cell Culture Techniques; Cells; Circulatory Collapse; Coagulation Factor IV; Coloring Agents; Defibrillation, Electric; Detection; Dyes; Dysfunction; Electric Countershock; Electrodes; Electroporation; Electroversion, Cardiac; Electroversions, Cardiac; Endocardium; Epicardium; FLR; Factor IV; Failure (biologic function); Family suidae; Fiber Optics; Foundations; Functional disorder; Goals; Heart; Heart Arrhythmias; Heart failure; Individual; Ischemia; Knowledge; Left; Maps; Measurement; Measures; Mechanics; Membrane; Membrane Potentials; Methods; Methods and Techniques; Methods, Other; Muscle, Cardiac; Muscle, Heart; Myocardium; Optics; Pain; Painful; Patients; Phase; Physiopathology; Pigs; Play; Preparation; Reperfusion Therapy; Resting Potentials; Role; Shock; Suidae; Swine; Sympathins; System; System, LOINC Axis 4; Techniques; Technology; Testing; Tissues; Transmembrane Potentials; Ventricular; Ventricular Fibrillation; base; cardiac failure; cardiac muscle; circulatory shock; defibrillation; electric countershock heart resuscitation; failure; heart cell; heart muscle; improved; membrane structure; novel; pathophysiology; porcine; prevent; preventing; public health relevance; reperfusion; response; restoration; seal; social role; suid; uptake; virtual",Mechanisms of Defibrillation & Shock-Induced Arrhythmias," Project Narrative Cardiac defibrillation using electrical shocks can be painful, damaging to the heart or it may fail, especially after prolonged fibrillation. The goal of this project is to understand the effects of electrical shocks on the heart and the role of the calcium-handling system in shock failure using novel methods for intramural optical measurements of membrane potential and intracellular calcium. The successful fulfillment of this project will improve understanding of both ventricular fibrillation and defibrillation which may provide foundation for targeted improvement of defibrillation therapy.",67748,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,7,253750,
7755372,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL067795-08,,NHLBI:389913;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PROVIDENCE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,001785542,US,RI,02912,BROWN UNIVERSITY,"HARRINGTON, ELIZABETH O;",1906511;,5R01HL067795,08/01/2001,01/31/2012,"ATP-protein phosphotransferase; Actins; Actomyosin; Acute; Acute Pulmonary Injury; Adherens Junction; Adhering Junction; Adhesion Plaques; Adhesions; Adhesive Junction; Adhesives; Agonist; Alveolar; Anchoring Junction; Aspiration, Respiratory; Basal Cell; Blood Vessels; Blood capillaries; Breathing; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Junctions; Cell Signaling; Cell surface; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cells; Chemicals; Cold-Insoluble Globulins; Complex; Data; Dysfunction; ECM; Endothelium; Exposure to; Extracellular Matrix; Extracellular Matrix, Integrins; FN1; FNZ; Fibronectin 1; Fibronectins; Figs; Figs - dietary; Filament; Focal Adhesions; Focal Contacts; Functional disorder; Generations; Goals; In Vitro; Infiltration; Inflammatory; Inhalation; Inhaling; Injury; Inspiration, Respiratory; Integrins; Intercellular Junctions; Intracellular Communication and Signaling; Investigation; Investigators; Isoforms; LETS Proteins; LIM Domain Kinase 1; LIM kinase; LIMK protein; LIMK-1; LIMK1; Large External Transformation-Sensitive Protein; Lead; Left; Liquid substance; Lung; Lung Injury, Acute; Maintenance; Maintenances; Mediating; Molecular; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Pathway interactions; Patients; Pb element; Permeability; Physiopathology; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Kinase; Proteins; Pulmonary Edema; Recovery; Research; Research Personnel; Researchers; Respiratory System, Lung; Respiratory physiology; Rho-associated kinase; Rho-kinase; Role; Signal Transduction; Signal Transduction Systems; Signaling; Speed; Speed (motion); Stress Fibers; Surface; Thrombase; Thrombin; Trauma; Work; acute lung injury; alpha 2-Surface Binding Glycoprotein; biological signal transduction; capillary; cofilin; effective therapy; fibrinogenase; fluid; gene product; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hydroxyalkyl protein kinase; in vivo; inhibitor; inhibitor/antagonist; inspiration; intervention development; liquid; lung edema; lung function; lung injury; monolayer; new approaches; novel; novel approaches; novel strategies; novel strategy; overexpression; pathophysiology; pathway; phosphorylase b kinase kinase; prevent; preventing; programs; protein structure; pulmonary; respiratory function; rottlerin; social role; therapy development; treatment development; vascular",Endothelial Barrier Function Modulation by PKCDelta,,67795,RIBT,Respiratory Integrative Biology and Translational Research Study Section,,8,389913,
7759168,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL068130-09,,NHLBI:376788;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"ITALIANO, JOSEPH E;",3093367;,5R01HL068130,07/01/2001,12/31/2011,"280 kDa actin-binding protein; ABP 280; Actin Filaments; Actin-Binding Protein; Actins; Address; Adenosine Triphosphatase, Dynein; Antimorphic mutation; Biogenesis; Biological; Bizzozero's corpuscle/cell; Blood; Blood Platelets; Blood megakaryocyte; Bone Marrow; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cells; Cellular Matrix; Cellular biology; Cytoplasmic Granules; Cytoskeletal System; Cytoskeleton; DCTN-50 protein, human; DCTN2 protein, human; Data; Deetjeen's body; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Dysfunction; Electron Microscopy; Event; Fluorescence; Functional disorder; Funding; Goals; Hayem's elementary corpuscle; Health; Hemostasis; Hemostatic function; Immunoelectron Microscopy; Individual; Knock-out; Knockout; Knockout Mice; Knowledge; Laboratories; Lead; Length; Life; Location; Mammals, Mice; Marrow platelet; Mechanics; Megakaryocytes; Megalokaryocyte; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microfilaments; Microscopy; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Microtubule Bundle; Microtubules; Modeling; Molecular; Molecular Motors; Morphology; Murine; Mus; Myofilaments; Nature; Null Mouse; Organ System, Cardiovascular; Organelles; Origin of Life; Pathway interactions; Patients; Pb element; Peripheral; Physiopathology; Platelets; Play; Process; Production; Proteins; Pseudopodia; RBP50 protein, human; Regulation; Research; Research Proposals; Rest; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Platelets; Role; Slide; Staging; Structure; Surface; System; System, LOINC Axis 4; Testing; Thrombocytes; Thrombocytopenia; Thrombopenia; Thrombosis; Time; Time Study; Tubulin; VWF receptor; Vascular, Heart; Von Willebrand binding site; Work; base; cell biology; circulatory system; disease/disorder; dynactin 2 (p50) protein, human; dynamitin; dynein ATP phosphohydrolase (tubulin translocating); experiment; experimental research; experimental study; filamin; filamin 1; filamin A; gene product; granule; heavy metal Pb; heavy metal lead; human p50 dynamitin protein; improved; intracellular skeleton; knock-down; membrane structure; overexpression; p50 dynamitin protein, human; pathophysiology; pathway; prevent; preventing; research study; social role; thrombocyte/platelet; treatment strategy; von Willebrand factor receptor",Cytoskeletal Mechanisms of Platelet Formation,,68130,HT,Hemostasis and Thrombosis Study Section,,9,376788,
7754428,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL068702-08,,NHLBI:412038;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,PEDIATRICS,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"ABMAN, STEVEN HERBERT;",1902094;,5R01HL068702,06/20/2001,01/31/2011,"0-6 weeks old; Angiogenesis Inhibition; Angiogenic Factor; Angiogenic Inhibition; Animals; BPD; Biological Preservation; Birth; Blood Circulation; Blood Pressure, High; Blood Vessels; Bloodstream; Bronchopulmonary Dysplasia; CNOS; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell-Extracellular Matrix; Cellular Expansion; Cellular Growth; Chronic; Circulation; Clinical; Common Rat Strains; Congenital diaphragmatic hernia; Constitutive NOS; Data; Development; Differentiation and Growth; Disease; Disorder; Dysfunction; EC 1.14.13.39; ECM; ECNOS; EDRF Synthase; ENOS; Embryo; Embryonic; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Experimental Models; Experimental Models, Other; Extracellular Matrix; FLR; Factor, Angiogenesis; Failure (biologic function); Fetal Circulation, Persistent; Fetal Growth; Fetus; Functional disorder; Generalized Growth; Genetic; Genetics, Other; Gestation; Grant; Growth; Growth, Fetal; Guanylyl Cyclase-Activating Factor Synthase; Hyperplasia; Hyperplastic; Hypertension; Hypertension, Pulmonary; Hypoxia; Hypoxic; INFLM; In Vitro; Infant, Newborn; Inflammation; Injury; Intracellular Communication and Signaling; Investigators; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Leiomyocyte; Life; Lung; MTGN; Mammals, Rats; Mediating; Mitogens; Modeling; Models, Experimental; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; Myocytes, Smooth Muscle; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Newborn Infant; Newborns; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Other Genetics; Ovis; Oxygen Deficiency; Parturition; Pathogenesis; Patients; Pb element; Perinatal; Perinatal Pulmonary Hypertension; Persistent Fetal Circulation Syndrome; Persistent Pulmonary Hypertension of Newborn; Physiopathology; Play; Pregnancy; Preservation, Biologic; Preservation, Biological; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Publishing; Pulmonary Artery; Pulmonary Circulation; Pulmonary Hypertension; Pulmonary Vascular Resistance; Pulmonary artery structure; Rat; Rattus; Receptor Protein; Regulation; Reporting; Research Personnel; Researchers; Respiratory Circulation; Respiratory System, Lung; Role; Sheep; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Staging; Stem cells; Stress; Structure; Syndrome; Testing; Therapeutic; Tissue Growth; VEGFs; Vascular Endothelial Growth Factors; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Resistance, Pulmonary; Vascular remodeling; Vasoactive Agonists; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasopressor Agents; Vasorelaxation; Vegf; angiogenesis; base; biological signal transduction; cell growth; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; density; disease/disorder; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; failure; falls; fetal; heavy metal Pb; heavy metal lead; hemodynamics; human NOS3 protein; hyperpiesia; hyperpiesis; hypertensive disease; iNO; improved; improved functioning; in utero; infant chronic lung disease; inhaled nitric oxide; inhibitor; inhibitor/antagonist; insight; intrauterine growth; lung development; model development; mouse model; neonatal chronic lung disease; neonatal pulmonary hypertension; neonate; newborn chronic lung disease; newborn human (0-6 weeks); newborn pulmonary hypertension; novel; ontogeny; pathophysiology; postnatal; preservation; programs; pulmonary; pulmonary artery endothelial cell; pulmonary hypertension in neonate; pulmonary hypertension in newborn; pulmonary hypertension of neonate; pulmonary hypertension of newborn; receptor; social role; treatment strategy; vascular; vasculogenesis; vasopressor",Role of VEGF in Perinatal Pulmonary Hypertension,,68702,ZRG1,Special Emphasis Panel,,8,412038,
7754459,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL068878-10,,NHLBI:454100;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"CHEN, YUQING E;",6103136;,5R01HL068878,01/01/2002,12/31/2010,"3-mononitrotyrosine; 3-nitrotyrosine; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Acids; Adenoviral Vector; Adenovirus Vector; Affect; Affinity; Agonist; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Attenuated; BUdR; Back; Binding; Binding (Molecular Function); Binding Site Domain; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blood Circulation; Blood Vessels; Bloodstream; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Carbohydrates; Cardiovascular Diseases; Carotid Arteries; Cell Communication and Signaling; Cell Cycle Progression; Cell Death, Programmed; Cell Signaling; Cells; Chromatin; Circulation; Cleaved cell; Clinical; Collaborations; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Common Rat Strains; Complex; Computer Simulation; Computerized Models; Cytosolic Phospholipase A2; Cytosolic Phospholipase A2 Group IV; Cytosolic Phospholipase A2G4; Cytosolic Phospholipase A2IV; DNA; DNA Replication; DNA Synthesis; DNA biosynthesis; Deoxyribonucleic Acid; Development; Diabetes Mellitus; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Dose; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 3.1.1.4; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Enzymes; Exhibits; Fatty Acids; Fatty Acids, Unsaturated; GADD45; Gene Deletion; Gene Targeting; Generalized Growth; Generations; Genetic Alteration; Genetic Change; Genetic defect; Gifts; Growth; Human; Human, General; Hydrolysis; IRF-1; IRF1; IRF1 gene; Immunologic, Luciferase; In Situ Nick-End Labeling; In Vitro; Institutes; Intracellular Communication and Signaling; Investigators; Ketones; Knock-in; Knock-in Mouse; Knock-out; Knockout; Knowledge; L-Tyrosine; Laboratories; Lecithinase A2; Length; Lesion; Ligand Binding Domain; Ligands; Linoleic Acids; Lipids; Luciferases; MYH11; MYH11 protein, human; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Methods; Mice; Mice, Mutant Strains; Mice, Transgenic; Model System; Modeling; Models, Biologic; Models, Computer; Molecular; Molecular Interaction; Mononitrogen Monoxide; Morphology; Murine; Mus; Mutant Strains Mice; Mutate; Mutation; Myosin Heavy Chain, Smooth Muscle Isoform; Myosin, Heavy Polypeptide 11, Smooth Muscle; Nitrates; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear; Obesity; PLA(2)-IV; PLA2; PLA2-IV; PPAR; PPAR gamma; PPARG; PPARG1; PPARG2; PPARgamma; Pathogenesis; Pathway interactions; Peroxisome Proliferative Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor gamma; Peroxisome Proliferator-Activated Receptors; Phosphatides; Phospholipase A2; Phospholipase A2G4; Phospholipase A2IV; Phospholipids; Phosphorofluoridate; Physiologic; Physiological; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Rat; Rattus; Receptor Protein; Regulation; Reporter; Research; Research Institute; Research Personnel; Researchers; Role; SMHC; SMMHC; Schools, Medical; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Simulation, Computer based; Smooth Muscle Myosin Heavy Chain 11; Staining method; Stainings; Stains; Structure; TUNEL; TYR; Targetings, Gene; Testing; Thiazolidinedione Receptor; Time; Tissue Growth; Transgenic Mice; Transgenic Organisms; Tyrosine; Tyrosine, L-isomer; Universities; Unsaturated Fatty Acids; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uridine, 5-bromo-2'-deoxy-; Vascular Diseases; Vascular Disorder; Work; adeno vector; adenovector; adiposity; analog; biological signal transduction; blood vessel disorder; cPLA2; cardiovascular disorder; cleaved; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; corpulence; corpulency; corpulentia; defined contribution; denitration; design; designing; diabetes; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; fluorophosphate; gain of function; gene deletion mutation; gene product; genetic manipulation; genome mutation; human MYH11 protein; in silico; in vitro Model; in vivo Model; inhibitor; inhibitor/antagonist; injured; insight; lecithinase A; loss of function; mRNA; medical schools; model organism; mouse mutant; mutant; new therapeutics; next generation therapeutics; nitration; nitroalkene; nitrotyrosine; novel; novel therapeutics; obese; obese people; obese person; obese population; ontogeny; overexpression; para-Tyrosine; pathway; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; phospholipase A2 IV; programs; receptor; receptor structure function; recombinase; research study; response; social role; structural biology; success; terminal nick end labeling; transcription factor; transgenic; vascular; vascular inflammation; virtual simulation",PPARgamma and Vascular Lesion Formation,,68878,VCMB,Vascular Cell and Molecular Biology Study Section,,10,454100,
7760172,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL069000-08,,NHLBI:388750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PISCATAWAY,UNITED STATES,PHYSIOLOGY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"MA, JIANJIE ;",1867627;,5R01HL069000,12/01/2001,01/31/2012,"4-3 Hydrophobic Repeat; Ablation; Address; Affect; Aging; Animal Model; Animal Models and Related Studies; Architecture; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Boxing; Ca Release Channel-Ryanodine Receptor; Calcium Ion Signaling; Calcium Signaling; Calcium-Ryanodine Receptor Complex; Cardiac; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cell surface; Cells; Co-Immunoprecipitations; Coiled-Coil Domain; Complexes, Macromolecular; Confocal Microscopy; Coupling; Cytoplasmic Membrane; DNA Molecular Biology; DPYK1 protein, Dictyostelium discoideum; Dependence; Dictyostelium discoideum SplA protein; Dihydropyridine Receptors; Dysfunction; Electron Microscopy; Engineering / Architecture; Ensure; Event; Exercise; Exercise, Physical; Exhibits; Functional disorder; Funding; Gene Combinations; Genetic; Heart myocyte; Image; Intracellular Communication and Signaling; Investigators; L-Type VDCC alpha-1 Subunit; Lead; Left-Handed Twist; Libraries; Life; M-caveolin; Macromolecular Complexes; Mammals, Mice; Measurement; Mediating; Membrane; Membrane Protein Traffic; Membrane Traffic; Mice; Microscopy, Confocal; Molecular; Molecular Biology; Molecular Interaction; Murine; Mus; Muscle; Muscle Cell Contraction; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle Contraction; Muscle Fatigue; Muscle Fibers; Muscle Tissue; Muscle function; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Fatigue; Myocytes; Myocytes, Cardiac; Myotubes; Names; Nature; Pathway interactions; Pb element; Performance; Phenotype; Physiology; Physiopathology; Plasma Membrane; Play; Process; Programs (PT); Programs [Publication Type]; Protein Biochemistry; Protein Family; Protein/Amino Acid Biochemistry; Proteins; Proteomics; RBCC/TRIM Motif; RNA, Small Interfering; Receptors, Ryanodine; Regulation; Regulatory Protein; Research; Research Personnel; Researchers; Rhabdomyocyte; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Sarcolemma; Sarcoplasmic Reticulum; Screening procedure; Senescence; Series; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Small Interfering RNA; SplA protein, Dictyostelium discoideum; Staining method; Stainings; Stains; Striated Muscle Tissue; Striated Muscles; Structure; TRIM Motif; Testing; Therapeutic; Triad; Triad Acrylic Resin; Triad resin; Tripartite Motif; Tubular; Tubular formation; V (voltage); VESCL; Vesicle; base; biological signal transduction; cardiomyocyte; caveolin-3; cell imaging; cellular imaging; computerized data processing; data processing; experiment; experimental research; experimental study; extracellular; gene product; genetic regulatory protein; heavy metal Pb; heavy metal lead; imaging; imaging modality; indexing; insight; junctophilin; junctophilin-1; junctophilin-2; junctophilin-3; membrane structure; model organism; novel; overexpression; patch clamp; pathophysiology; pathway; plasmalemma; programs; regulatory gene product; research study; screening; screenings; senescent; siRNA; signal processing; skeletal; social role; splA kinase, Dictyostelium discoideum; spore lysis A protein, Dictyostelium discoideum; voltage",Bi-directional Calcium Signaling in Striated Muscles,,69000,ZRG1,Special Emphasis Panel,,8,388750,
7743399,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL069182-07,,NHLBI:376250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PORTLAND,UNITED STATES,,01,071732663,US,ME,041023175,MAINE MEDICAL CENTER,"LINDNER, VOLKHARD ;",1965839;,5R01HL069182,10/01/2001,01/31/2014,"Adventitia; Adventitial Cell; Affect; Alleles; Allelomorphs; Amino Acids; Antibodies; Antisera; Arteries; Assay; Bioassay; Biochemical; Biogenesis; Biologic Assays; Biological; Biological Assay; Birth; Bleeding; Blood Vessels; Blotting, Northern; Body Tissues; Bone; Bone Injury; Bone Matrix; Bone and Bones; Bone-Derived Transforming Growth Factor; Bones and Bone Tissue; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cessation of life; Characteristics; Chordata; Chordates; Chronic Disease; Chronic Illness; Collagen; Collagen Type I; Common Rat Strains; Cytoplasm; Cytoplasmic Protein; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Development; Disease; Disorder; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Family member; Fibrinolysin; Fibrosis; Funding; Future; Gametes; Gene Expression; Gene Targeting; Generations; Genes; Genetic; Genetics, in situ Hybridization; Germ Cells; Germ-Line Cells; Glu-Plasmin; Goals; Golgi; Golgi Apparatus; Golgi Complex; Hemorrhage; Human; Human, General; Immune Sera; Immunoblotting; In Situ Hybridization; In Vitro; Injury; Intracellular Communication and Signaling; Laboratories; Leiomyocyte; Length; Lesion; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Messenger RNA; Methods; Mice; Mice, Mutant Strains; Mice, Transgenic; Milk Growth Factor; Modeling; Molecular Weight; Mouse Strains; Murine; Mus; Muscle, Involuntary; Muscle, Smooth; Mutant Strains Mice; Myocytes, Smooth Muscle; Nomenclature; Northern Blotting; Northern Blottings; Origin of Life; Parturition; Penetrance; Peptide Signal Sequences; Pericapillary Cell; Pericytes; Perivascular Cell; Phenotype; Physiologic; Physiological; Plasmin; Platelet Transforming Growth Factor; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protease F; Proteins; Proteolytic Clipping; Proteolytic Processing; RNA blot analysis; RNA blotting; RNA, Messenger; Rat; Rattus; Regulation; Reporting; Reproductive Cells; Resistance; Role; Rouget Cells; Rupture; Secondary to; Sex Cell; Signal Pathway; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Subcellular Process; TGF B; TGF-beta; TGFbeta; Targetings, Gene; Testing; Tissues; Trans-Activation (Genetics); Transactivation; Transcript; Transforming Growth Factor beta; Transgenic Mice; Trees; Tunica Adventitia; Type 1 Collagen; VESCL; Vesicle; aminoacid; arterial remodeling; biological signal transduction; blood loss; bone; cell type; chronic disease/disorder; chronic disorder; clinical data repository; clinical data warehouse; data repository; design; designing; disease/disorder; gain of function; gene product; in situ Hybridization Staining Method; in vivo; initial cell; injured; interest; interstitial; loss of function; mRNA; male; mouse model; mouse mutant; mutant; mutant mouse model; novel; novel marker; overexpression; postnatal; protein signal sequence; public health relevance; recombinase; relational database; repair; repaired; resistant; sexual cell; social role; trafficking; triple helix; vascular",Cthrc1 function as a novel TGF-beta antagonist in the vasculature," We identified the novel protein Cthrc1 and discovered its ability to potently suppress collagen production. Excessive collagen production is a hallmark of all fibrosing disorders associated with chronic diseases, and 45% of all deaths in the USA are ultimately attributable to such disorders. With its ability to inhibit collagen production, Cthrc1 could be very suitable for the development of future antifibrotic therapies.",69182,VCMB,Vascular Cell and Molecular Biology Study Section,,7,376250,
7765504,R01,HL,5,,01/01/2010,12/31/2010,PA-07-012,5R01HL069438-07,,NHLBI:423750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"FRENETTE, PAUL S;",2089342;,5R01HL069438,09/30/2001,12/31/2011,"Adhesions; Affect; Alpha-Fucosyltransferases; Animal Model; Animal Models and Related Studies; Animal Welfare; Bibliography; Blood Flow Velocity; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Precursor Cell; Blood Segmented Neutrophil; Blood Vessels; Blood erythrocyte; Blood leukocyte; Blood normocyte; C57BL/6 Mouse; CD162 antigen; CD44; CD44 gene; CD62E Antigens; CR3; CR3 Receptor; Cell Adhesion Molecule E-Selectin; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Chronic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Communication, Personal; Country; Data; Defect; Down-Regulation; Down-Regulation (Physiology); Downregulation; E-Selectin; ELAM-1; Ecological impact; Endothelial Adhesion Molecule 1; Endothelial Leukocyte Adhesion Molecule-1; Environment; Environmental Impact; Equipment; Erythrocytes; Erythrocytic; Ethics Committees, Research; Extracellular Matrix, Integrins; Fluorescence Microscopy; Fucosyltransferase; Funding; Generalized Growth; Generations; Genetic; Glycoproteins; Golgi; Golgi Apparatus; Golgi Complex; Growth; Hb SS disease; HbSS disease; Hematologic Body System; Hematopoietic; Hematopoietic Body System; Hematopoietic System; Hematopoietic stem cells; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hemolysis; Heterophil Granulocyte; IACUC; IRBs; IVM; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Integrin alpha-M beta-2; Integrin alphaMbeta2; Integrins; International; Interpersonal Communication; Intracellular Communication and Signaling; Knockout Mice; LECAM-2; Laboratories; Lead; Leukocyte Endothelial Cell Adhesion Molecule 2; Leukocytes; Life; Ligands; MDU3; Mac 1; Mac-1 Adhesive Receptor; Mac-1 Antigen; Mac-1 Receptor; Macrophage-1 Antigen; Mammals, Mice; Marrow Neutrophil; Marrow erythrocyte; Marrow leukocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Microscopy, Video; Modeling; Molecular; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Organ; Organ System, Hematologic; P-selectin glycoprotein ligand-1; P-selectin ligand protein; PSGL-1; Pathology; Patients; Pb element; Personal Communication; Pgp1; Phenotype; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Radiation Chimera; Receptor Protein; Receptor, Complement 3; Receptor, Mo1 Antigen; Receptor, Mo1 Glycoprotein; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Leukocytes; Role; Selectins; Sequence-Specific Posttranscriptional Gene Silencing; Sickle Cell; Sickle Cell Anemia; Signal Transduction; Signal Transduction Systems; Signaling; Speed; Speed (motion); Stream; Structure of venule; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Time; Tissue Growth; Venules; Vertebrate Animals; Vertebrates; Video Microscopy; Videomicrography; Videomicroscopy; White Blood Cells; White Cell; abstracting; biological signal transduction; blood corpuscles; cell transduction; cellular transduction; clinical investigation; clinical relevance; clinically relevant; digital; drepanocyte; endothelial leukocyte adhesion molecule; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; human subject; improved; in vivo; insight; intervention therapy; intravital microscopy; knockout animal; lentiviral-mediated; leukocyte activation; model organism; neutrophil; new therapeutics; next generation therapeutics; novel; novel therapeutics; ontogeny; preclinical study; prevent; preventing; programs; receptor; reconstitute; reconstitution; research study; sickle RBC; sickle cell disease; sickle disease; sickle erythrocyte; sickle red blood cell; sicklemia; sickling; skeletal; social role; therapeutic target; transduced cells; vascular; venule; vertebrata; white blood cell; white blood corpuscle",Adhesion mechanisms mediating sickle cell vasoocclusion in vivo,,69438,ELB,Erythrocyte and Leukocyte Biology Study Section,,7,423750,
7758761,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL070101-05,,NHLBI:356843;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,KANSAS CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"DILEEPAN, KOTTARAPPAT N;",1961506;,5R01HL070101,02/01/2006,01/31/2011,"1H-Imidazole-4-ethanamine; 3-10C; AMCF-I; APOE [{C0003595}]; Adhesion Molecule; Adhesions; Apo-E; ApoE; Apolipoprotein E; Applications Grants; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basophilic Histiocyte; Basophils, Tissue; Blood Coagulation Factor IV; Blood leukocyte; Blood monocyte; Blotting, Western; C. pneumoniae; C.pneumoniae; CCL2; CCL2 gene; CMV; COX-2 protein; COX2; COX2 enzyme; CXCL8; Ca++ element; Calcium; Cardiac artery; Cell Adhesion Molecules; Cell Degranulation; Cell Wall; Cells; Chlamydia pneumoniae; Chlamydophila pneumoniae; Chymase; Coagulation Factor IV; Communication; Confocal Microscopy; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Circulation; Coronary artery; Cyclo-Oxygenase-2; Cyclooxygenase; Cytofluorometry, Flow; Cytomegalovirus; Development; Differentiation Factor, B-Cell; Disease; Disorder; EC 2.7.2-; ELISA; Endothelial Cells; Endothelium; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Event; Extracellular Signal-Regulated Kinases; Factor IV; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Foam Cells; G-Proteins; GCP-1; GCP1; GDCF-2; GDCF-2 HC11; GTP-Binding Proteins; GTP-Regulatory Proteins; Gene Deletion; Genetic Polymorphism; Gram-Positive Bacteria; Grant Proposals; Grants, Applications; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HC11; HCMV; HPGF; Heart artery; Hepatocyte-Stimulating Factor; Histamine; Histamine Receptor; Histidine Carboxy-Lyase; Histidine Decarboxylase; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL-8; IL6 Protein; IL8; IL8 gene; INFLM; Immune; Immune system; Immunofluorescence; Immunofluorescence Immunologic; Immunoglobulin Enhancer-Binding Protein; Immunologic, Immunofluorescence; In Vitro; Infection; Infectious Agent; Inflammation; Inflammatory Response; Interleukin 6 (Interferon, Beta 2); Interleukin-6; K60; Knockout Mice; L-Histidine carboxy-lyase; LECT; LPS; LUCT; LYNAP; Lead; Leiomyocyte; Leukocytes; Ligands; Lipopolysaccharides; MAP kinase; MAPK; MCAF; MCP-1; MCP1; MDNCF; MGC9434; MGI-2; MMCP-1; MONAP; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Marrow leukocyte; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microfluorometry, Flow; Microorganisms, General; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Molecular; Murein; Murine; Mus; Myeloid Differentiation-Inducing Protein; Myocytes, Smooth Muscle; NAF; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; PAR-2 Receptor; PAR2 Receptor; PGH Synthase 2; PGHS-2; PGHS2; PGI2; PGX; PHS II; PTGS2; Participant; Pathogenesis; Pathway interactions; Patients; Pattern; Pb element; Peptidoglycan; Plasmacytoma Growth Factor; Polymorphism (Genetics); Polymorphism, Genetic; Production; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostacyclins; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase 2; Prostaglandin I(2); Prostaglandin I2; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins I; Protease-Activated Receptor 2; Proteinase Activated Receptor 2; Pylorus; RNA, Messenger; Receptor, PAR-2; Reticuloendothelial System, Leukocytes; Risk; Role; SCYA2; SCYB8; SMC-CF; Salivary Gland Viruses; Scheme; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Streaks, Arterial Fatty; TIL4; TLR protein; TLR2; TLR2 gene; TLR2 receptor; TLR4; TLR4 gene; TOLL; TSG-1; Techniques; Teichoic acid, lipo-; Testing; Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Thromboxane A2; Time; Toll-Like Receptor 2; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin 1 Receptor-Like Protein 4; Transcription Factor NF-kB; Trypsin Receptor; Tryptase; Umbilical vein; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Diseases; Vascular Disorder; Western Blotting; Western Blottings; Western Immunoblotting; White Blood Cells; White Cell; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; b-ENAP; blood vessel disorder; body system, allergic/immunologic; calcification; cell adhesion protein; chymase-1; chymotrypsin-like protease; cyclo-oxygenase II; cyclooxygenase 2; cytokine; cytomegalovirus group; disease/disorder; flow cytophotometry; gene deletion mutation; hToll; heavy metal Pb; heavy metal lead; human cytomegalovirus; in vivo; infectious organism; interest; interferon beta 2; kappa B Enhancer Binding Protein; lipoteichoic acid; lung tryptase; mRNA; mast cell; mast cell protease; mast cell protease 1; mast cell protease I; mast cell protease II; mast cell proteinase-1; mast cell tryptase; mastocyte; microorganism; monocyte; mouse model; novel; nuclear factor kappa beta; organ system, allergic/immunologic; pathogen; pathway; polymorphism; prostaglandin H synthase-2; prostaglandin X; protein blotting; response; skeletal muscle protease; skin tryptase; social role; vascular inflammation; vulnerable plaque; white blood cell; white blood corpuscle",Mast Cell-Induced Inflammation in Vascular Disease,,70101,VCMB,Vascular Cell and Molecular Biology Study Section,,5,356843,
7760145,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL070244-08,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SYRACUSE,UNITED STATES,ANATOMY/CELL BIOLOGY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"TURNER, CHRISTOPHER E;",1887218;,5R01HL070244,02/15/2007,01/31/2011,"Actins; Adhesion Plaques; Adhesions; Antibodies; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phospho-Specific; Antigenic Determinants; Assay; Binding; Binding (Molecular Function); Binding Determinants; Binding Sites; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blotting, Western; Body Tissues; Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication; Cell Communication and Signaling; Cell Growth in Number; Cell Interaction; Cell Locomotion; Cell Migration; Cell Migration Assay; Cell Movement; Cell Multiplication; Cell Polarity; Cell Proliferation; Cell Signaling; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cell-to-Cell Interaction; Cells; Cellular Matrix; Cellular Migration; Cellular Proliferation; Chimera Protein; Chimeric Proteins; Co-Immunoprecipitations; Combining Site; Complex; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Defect; Deletion Mutagenesis; ECM; Embryo Development; Embryogenesis; Embryonic Development; Endocytosis; Epitopes; Event; Extracellular Matrix; Extracellular Matrix, Integrins; FRET; Family; Fibroblasts; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; Focal Adhesions; Focal Contacts; Funding; Fusion Protein; GFAC; GTP Phosphohydrolases; GTPases; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; In Vitro; Integrin Signaling Pathway; Integrins; Intracellular Communication and Signaling; K element; MAP-ERK Kinase; MAPK ERK Kinases; MEKs; Maintenance; Maintenances; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Microscopy, Video; Migration Assay; Molecular; Molecular Interaction; Monitor; Motility; Motility, Cellular; Musculoskeletal; Myosin Light Chains; Neoplasm Metastasis; Nocodazole; Oncodazole; Organ System, Cardiovascular; Phospho-Specific Antibodies; Phosphopeptide-Specific Antibodies; Phosphorylation; Phosphorylation State-Specific Antibodies; Phosphospecific Antibody; Physiologic; Physiological; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Potassium; Precipitation; Process; Protein Binding Domain; Protein Binding Motif; Protein Phosphorylation; Protein-Protein Interaction Domain; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Reactive Site; Regulation; Role; Scaffolding Protein; Secondary Neoplasm; Secondary Tumor; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Testing; Time; Tissues; Transfection; Tumor Cell Migration; Vascular, Heart; Video Microscopy; Videomicrography; Videomicroscopy; Western Blotting; Western Blottings; Western Immunoblotting; actopaxin; biological signal transduction; cancer metastasis; cell behavior; cell motility; cellular polarity; circulatory system; cofilin; gene product; guanosinetriphosphatase; insight; intersectin; intersectin 1; intracellular skeleton; mimetics; mutant; p21 activated kinase; paxillin; protein blotting; protein protein interaction; repair; repaired; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; scaffold; scaffolding; siRNA; social role; wound",ILK-Actopaxin Interactions in Cell Signaling,,70244,ICI,Intercellular Interactions,,8,392500,
7762716,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL070320-08,,NHLBI:423750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,BIOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"YELLEN, GARY I;",1891111;,5R01HL070320,04/01/2002,01/31/2012,"3'5'-cyclic ester of AMP; Accounting; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Articular Range of Motion; Behavior; Binding; Binding (Molecular Function); Brain; CD 2+; CD2+; Cells; Charge; Complement; Complement Proteins; Complication; Coupling; Crosslinker; Cyclic AMP; Cyclic Nucleotides; Cysteine; Data; Distance Learning; Disulfides; Encephalon; Encephalons; Equilibrium; Extravasation; Family member; Future; Gated Ion Channel; Generations; Genetic Alteration; Genetic Change; Genetic defect; Geography; Grant; Half-Cystine; Heart; Investigators; Ion Channel; Ionic Channels; Ions; Joint Range of Motion; L-Cysteine; Leakage; Learning; Learning, Distance; Length; Life; Measurement; Measures; Mechanics; Membrane; Membrane Channels; Modification; Molecular; Molecular Interaction; Movement; Mutation; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nucleotides, Cyclic; Operation; Operative Procedures; Operative Surgical Procedures; Organism-Level Process; Organismal Process; Pace Stimulators; Pacemakers; Peptide Domain; Physiologic Processes; Physiological Processes; Physiology; Population; Position; Positioning Attribute; Probability; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Domains; Range of Motion, Articular; Research Personnel; Researchers; Site; Spillage; Stimulators, Electrical, Pace; Surgical; Surgical Interventions; Surgical Procedure; Tertiary Protein Structure; V (voltage); Variant; Variation; Work; adenosine 3'5' monophosphate; balance; balance function; base; body movement; brain cell; cAMP; cadmium ion; genome mutation; interest; member; membrane structure; mutant; neuronal; programs; range of motion; response; sensor; surgery; tool; voltage; voltage gated channel",Molecular physiology of pacemaker channels,,70320,BPNS,Biophysics of Neural Systems Study Section,,8,423750,
7762717,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL071078-07,,NHLBI:398253;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,STANFORD,UNITED STATES,BIOPHYSICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"KOBILKA, BRIAN K;",1886292;,5R01HL071078,09/15/2002,01/31/2013,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 21+ years old; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; AKT; Address; Adrenaline; Adrenergic Receptor; Adrenoceptors; Adult; Affect; Affinity; Agonist; Akt protein; Animal Welfare; Assay; Behavior; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; C 4c; C4c; Cardiac; Cardiac Myocytes; Cardiocyte; Catecholamines; Caveolae; Caveolas; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cellular Matrix; Chemotherapy-Hormones/Steroids; Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Co-culture; Cocultivation; Coculture; Coculture Techniques; Complex; Country; Critiques; Cultured Cells; Cytoskeletal System; Cytoskeleton; Data; Detergents; Ecological impact; Electrophysiology; Electrophysiology (science); Endocrine Gland Secretion; Endocytic Vesicle; Endocytotic Vesicle; Environment; Environmental Impact; Epi; Epinephrine; Equipment; Ethics Committees, Research; Family; Funding; Fusion Protein; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-Proteins; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Genetic Alteration; Genetic Change; Genetic defect; Genome, Human; Goals; Grant; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HDL; Hand; Health; Heart; Heart failure; Heart myocyte; Heavy Lipoproteins; High Density Lipoproteins; High density lipoprotein; Hormones; Human Genome; Human, Adult; IACUC; IRBs; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigation; Investigators; Levarterenol; Levonorepinephrine; Ligand Binding; Ligands; Lipid Rafts, Cell Membrane; Lipoproteins, HDL; Location; Measurement; Membrane; Membrane Microdomains; Methods; Model System; Models, Biologic; Molecular Interaction; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Mutagenesis, Site-Directed; Mutation; Myocytes; Myocytes, Cardiac; Neonatal; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neuromediator Receptors; Neurons; Neurophysiology / Electrophysiology; Neuroregulator Receptors; Neurotransmitter Receptor; Noradrenaline; Norepinephrine; PKB protein; Pathogenesis; Phosphorylation; Physiologic; Physiological; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Kinase B; Protein Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; Quelling; RAC-PK protein; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Receptor Signaling; Receptors, Epinephrine; Receptors, Neurohumor; Recycling; Regulation; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Scaffolding Protein; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specificity; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stream; Structure; Sympathetic Ganglia; Sympathins; Synapses; Synaptic; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Therapeutic Epinephrine; Therapeutic Hormone; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; United States; Vertebrate Animals; Vertebrates; abstracting; adenoreceptor; adult human (21+); alpha-Lipoproteins; base; biological signal transduction; c-akt protein; cardiac failure; cardiomyocyte; cell type; complement 4c; complement C4c; d-Numb; design; designing; experiment; experimental research; experimental study; expiration; gene product; genome mutation; human subject; in vivo; innervation; interest; intracellular skeleton; lipid raft; membrane structure; mutant; nano disk; nanodisk; nerve supply; neuronal; novel; numb protein; patch clamp; programs; protein complex; protein expression; protein protein interaction; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; receptor; receptor function; receptor internalization; related to A and C-protein; research study; response; social role; synapse formation; synaptogenesis; trafficking; vertebrata",Beta Adrenoceptor Signaling Complexes in Innervated Cardiac Myocytes,,71078,BPNS,Biophysics of Neural Systems Study Section,,7,398253,
7762742,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL071207-08,,NHLBI:457780;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PEDIATRICS,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"GELB, BRUCE D;",1892756;,5R01HL071207,08/01/2002,01/31/2013,"Accounting; Address; Alleles; Allelomorphs; Animal Welfare; BPTP3; Bibliography; Biochemical; C-K-RAS; CFC; Candidate Disease Gene; Candidate Gene; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Congenital Heart Defects; Country; DNA Resequencing; Data; Defect; Development; Disease; Disorder; Drosophila; Drosophila genus; EC 2.7.2-; Ecological impact; Embryonic Heart; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Extracellular Signal-Regulated Kinases; Fruit Fly, Drosophila; Future; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genotype; HC phosphatase; Hcph gene product; HePTP; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Italy; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; LEOPARD Syndrome; Left; Lentiginosis; Lentigo; MAP kinase; MAPK; Mammals, Mice; Mental Retardation; Methods; Mice; Mill Hill-2 Viral Oncogene Homolog; Missense Mutation; Mitogen-Activated Protein Kinases; Modeling; Molecular; Multiple Lentigines Syndrome; Murine; Mus; Mutate; Mutation; Mutation, Missense; NS1; Noonan Syndrome; Oncogene K-Ras; Oncogene, K-Ras-2; PTP-1D; PTP2C; PTPN11; PTPN11 gene; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; RAF-1; RAF1; RAF1 gene; RASK2; Research; Research Design; Research Ethics Committees; Research Resources; Resequencing; Resources; Role; SH-PTP1; SH-PTP2; SH-PTP3; SHP PTPase; SHP-1; SHP-1 phosphatase; SHP-1 tyrosine phosphatase; SHP-2; SHP1 gene product, phosphatase; SHP1 phosphatase; SHP1 protein tyrosine phosphatase; SHP2; SHPTP1; Side; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Stream; Study Type; Testing; Time; Transgenic Organisms; Turner phenotype with normal karyotype; Turner syndrome in female with X chromosome; Turner-like syndrome; Ullrich-Noonan syndrome; Update; Vertebrate Animals; Vertebrates; Wing; abstracting; autosomal dominant trait; biological signal transduction; cardiogenesis; cohort; congenital cardiac disorder; congenital heart disease; congenital heart disorder; disease/disorder; experiment; experimental research; experimental study; expiration; familial Turner syndrome; fascinate; fruit fly; gain of function; gene product; genome mutation; haematopoietic cell phosphatase; heart defect; heart development; hematopoietic cell-specific tyrosine phosphatase SHP-1; human hematopoietic tyrosine phosphatase; human subject; insight; loss of function; male Turner syndrome; mutant; new therapeutics; next generation therapeutics; novel; novel therapeutics; programs; protein-tyrosine phosphatase SHP; pseudo-Ullrich-Turner syndrome; research study; social role; study design; transgenic; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; v-RAF-1 Murine Leukemia Viral Oncogene Homolog 1; vertebrata",Molecular studies of Noonan syndrome and related disorders,,71207,CDD,Cardiovascular Differentiation and Development Study Section,,8,457780,
7751904,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL071798-06,,NHLBI:390836;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"KNOWLES, MICHAEL R;",2077872;,5R01HL071798,12/01/2002,12/31/2012,"Adenosine Triphosphatase, Dynein; Adverse effects; Affect; Alleles; Allelomorphs; Amish; Arkansas; Arm; Asthma; Bronchial Asthma; Bronchitis, Chronic; COAD; COPD; Candidate Disease Gene; Candidate Gene; Causality; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Migration; Chronic Bronchitis; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Cilia; Clinical; Complex; DNA Alteration; DNA mutation; Data; Defect; Diagnosis; Diagnostic; Disease; Disorder; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Effectiveness; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Epithelium; Epithelium, Respiratory; Etiology; Family; Frequencies (time pattern); Frequency; Future; Gases; Gene Alteration; Gene Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genetic mutation; Genetic screening method; Genetics, Human; Goals; Hereditary Disease; Human; Human Genetics; Human, General; Kartagener Syndrome; Kartagener Triad; Lead; Life; Lung; Lung diseases; Man (Taxonomy); Man, Modern; Microscopy, Video; Missouri; Molecular; Molecular Disease; Mononitrogen Monoxide; Motility; Motility, Cellular; Mucociliary Clearance; Mucociliary Transport; Mutation; Nasal; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nose; Nose, Nasal Passages; Pathogenesis; Patients; Pb element; Pennsylvania; Phase; Phenotype; Polynesian bronchiectasis; Predisposition; Primary Ciliary Dyskinesias; Production; Proteomics; Pulmonary Disease, Chronic Obstructive; Pulmonary Diseases; Pulmonary Disorder; Radial; Research; Residual; Residual state; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory System, Nose, Nasal Passages; Respiratory physiology; Role; Sequence Alteration; Situs Inversus; Speed; Speed (motion); Structure; Structure of respiratory epithelium; Susceptibility; TEM; Testing; Transmission Electron Microscopy; Treatment Side Effects; Upper arm; Video Microscopy; Videomicrography; Videomicroscopy; Work; base; cell motility; clinical phenotype; design; designing; disease causation; disease control; disease etiology; disease-causing mutation; disease/disorder; disease/disorder etiology; disorder control; disorder etiology; dynein ATP phosphohydrolase (tubulin translocating); endothelial cell derived relaxing factor; genetic disorder; genetic testing; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; heterotaxia syndrome; heterotaxy; insight; inversion of viscera; laterality sequence; lung disorder; lung function; mutant; novel; primary ciliary dyskinesia; public health relevance; pulmonary; respiratory; respiratory function; side effect; situs abnormality; situs inversus viscerum; social role; stroke recovery; therapy adverse effect; transposition of viscera; treatment adverse effect; visceral heterotaxy; visceral transposition",Pathogenesis of PCD Lung Disease," Project Narrative The overall short-term goals of this project are to 1) study genes that are key to the function of respiratory cilia to protect the normal lung, and 2) define the effects of adverse genetic mutations that reduce the effectiveness of ciliary function and mucociliary clearance, and cause Primary Ciliary Dyskinesia (PCD), which results in life-shortening lung disease. The long-term goal of this project is to develop better understanding of the underlying genetic variability that adversely affects ciliary function, and predisposes to common airway diseases, such as asthma and chronic obstructive pulmonary disease.",71798,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,6,390836,
7762729,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL072841-07,,NHLBI:489908;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WATERTOWN,UNITED STATES,,07,058893371,US,MA,02472,BOSTON BIOMEDICAL RESEARCH INSTITUTE,"IKEMOTO, NORIAKI ;",1877021;,5R01HL072841,04/01/2003,01/31/2012,"(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; ANF; ANH; ANP; Acetates; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Animal Welfare; Antibodies; Arrhythmia; Arrhythmogenic Right Ventricular Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia; Atrial Natriuretic Factor; Atriopeptins; Auriculin; Australia; Benzophenones; Bibliography; Binding; Binding (Molecular Function); Binding Proteins; Bovine Serum Albumin; Ca Release Channel-Ryanodine Receptor; Ca(2+)-Calmodulin Dependent Protein Kinase; CaM KII; CaM PK II; CaM kinase II; CaMKII; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium-Ryanodine Receptor Complex; Calmodulin; Calmodulin-Dependent Protein Kinases; Calmodulin-Kinase; Calsequestrin; Carboxylic Acids; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Central Core Disease; Central Core Myopathy; Country; Coupled; Coupling; Cresol; Cresols; Cyan Fluorescent Protein; Cyclic AMP-Dependent Protein Kinases; Data; Defect; Dihydropyridine Receptors; Disease model; Dysfunction; EDN1; ET-1; ET-1 (Endothelin-1); Ecological impact; Endothelin Type 1; Endothelin-1; Environment; Environmental Impact; Equipment; Ethanedial; Ethanedione; Ethics Committees, Research; FK-506-Binding Protein; FK506 Binding Proteins; FKBP; FKBP Rotamase; FRET; Fluorescence Resonance Energy Transfer; Functional disorder; GFP; Genetic Alteration; Genetic Change; Genetic defect; Glyoxal; Goals; Green Fluorescent Proteins; HTRPY; Heart Arrhythmias; Heart Diseases; Heart failure; Hypertrophy; IACUC; IC50; IP3R; IP3R1; IRBs; ITPR1; ITPR1 gene; Impact, Environmental; Inhibitory Concentration 50; Insp3r1; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Ion Channels, Calcium; Japan; KBP; L-Type VDCC alpha-1 Subunit; Lead; Ligand Binding Protein; Link; Malignant Hyperpyrexia; Malignant Hyperpyrexias; Malignant Hyperthermia; Malignant hyperpyrexia due to anesthesia; Mediation; Molecular; Molecular Interaction; Muscle, Cardiac; Muscle, Heart; Muscle, Skeletal; Muscle, Voluntary; Mutation; Myocardium; Myopathy, Central Core; Natriuretic Peptides, Atrial; Negotiating; Negotiation; PKA; Pb element; Peptide Domain; Peptides; Phenylephrine; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Physiologic; Physiological; Physiopathology; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Domains; Protein Kinase A; Proteins; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, Ryanodine; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Rest; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; SERCA3; Serum Albumin, Bovine; Shy-Magee Syndrome; Skeletal Muscle Tissue; Skeletal muscle structure; Tacrolimus Binding Proteins; Tertiary Protein Structure; United Kingdom; VDCC; Ventricular; Vertebrate Animals; Vertebrates; Voltage-Dependent Calcium Channels; Work; abstracting; anesthesia related hyperthermia; atrial natriuretic hormone; cAMP-Dependent Protein Kinases; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cardiac failure; cardiac muscle; disorder model; expiration; gene product; genome mutation; heart disorder; heart muscle; heavy metal Pb; heavy metal lead; human subject; hyperthermia of anesthesia; pathophysiology; programs; receptor; sarcoplasmic reticulum calcium ATPase; social role; spatial relationship; tricresol; vertebrata",Regulation of Normal and Diseased Cardiac Ca2+ Channels,,72841,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,7,489908,
7763898,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL073328-08,,NHLBI:445725;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,PHARMACOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"TREJO, JOANN ;",1916402;,5R01HL073328,04/01/2003,12/31/2012,"APF-1; ATP-Dependent Proteolysis Factor 1; Accounting; Adaptor Protein; Adaptor Signaling Protein; Antimorphic mutation; Arrestins; Assay; Back; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Bizzozero's corpuscle/cell; Blood Clot; Blood Clotting; Blood Platelets; Blood Vessels; Blood coagulation; Cell Communication and Signaling; Cell Signaling; Cell surface; Cells; Clathrin; Clathrin Adaptors; Clathrin Assembly Proteins; Clathrin-Associated Adaptors; Clathrin-Associated Proteins; Clotting; Coagulants; Coagulation; Coagulation Factor II Receptor; Coagulation Process; Couples; Deetjeen's body; Dephosphin; Deposit; Deposition; Deubiquitinating Enzyme; Deubiquitination; Development; Diffuse; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Dynamin; Endopeptidase-Activated Receptors; Endothelial Cells; Enzymes; Esteroproteases; Event; F2R; Family; Fibrin; Fibroblasts; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-Proteins; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Generations; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; HMG-20; Hayem's elementary corpuscle; HeLa; Hela Cells; Hemostasis; Hemostatic function; High Mobility Protein 20; Human; Human, General; INFLM; Inflammation; Inflammatory Response; Injury; Intracellular Communication and Signaling; Leiomyocyte; Life; Ligand Binding; Ligands; Lysosomes; Man (Taxonomy); Man, Modern; Marrow platelet; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Modification; Molecular; Molecular Interaction; Myocytes, Smooth Muscle; PAR-1 Receptor; PAR1 Receptor; Pathway interactions; Peptidases; Peptide Hydrolases; Phosphorylation; Platelet Activation; Platelets; Prevention strategy; Preventive strategy; Process; Programs (PT); Programs [Publication Type]; Protease-Activated Receptor 1; Protease-Activated Receptors; Proteases; Protein Phosphorylation; Proteinase-Activated Receptor 1; Proteinase-Activated Receptors; Proteinases; Proteins; Proteolytic Enzymes; RNA, Small Interfering; Receptor Protein; Receptor Signaling; Receptor, PAR-1; Receptors, Proteinase-Activated; Recycling; Regulation; Research; Resistance; Reticuloendothelial System, Platelets; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Sorting - Cell Movement; Testing; Thrombase; Thrombin; Thrombocytes; Thrombosis; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; Vascular Diseases; Vascular Disorder; base; biological signal transduction; blood vessel disorder; cancer progression; desensitization; disease/disorder; epsin; experiment; experimental research; experimental study; fibrinogenase; gene product; insight; mutant; neoplasm progression; neoplastic progression; novel; pathway; programs; prototype; public health relevance; receptor; receptor internalization; research study; resistant; response; siRNA; social role; sorting; thrombocyte/platelet; trafficking; tumor progression; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-specific protease; vascular; vascular inflammation",Regulation of Protease-activated Receptor-1 Signaling,,73328,MBPP,Membrane Biology and Protein Processing Study Section,,8,445725,
7755011,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL073396-09,,NHLBI:347625;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,SURGERY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"ELICEIRI, BRIAN PATRICK;",1886926;,5R01HL073396,08/01/2002,01/31/2012,"21+ years old; Adult; Adventitial Cell; Affect; Animal Model; Animal Models and Related Studies; Assay; Astrocytes; Astrocytic Neoplasm; Astrocytic Tumor; Astrocytoma; Astrocytoma, Grade IV; Astrocytus; Astroglia; Astroglioma; BMK1; Basement membrane; Bioassay; Biologic Assays; Biological Assay; Biopsy; Biopsy Sample; Biopsy Specimen; Blood - brain barrier anatomy; Blood Vessels; Blood-Brain Barrier; Body Tissues; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Breast Carcinoma; Breast Neoplasms; Breast Tumors; Cancers; Carcinoma Cell; Cell Communication and Signaling; Cell Signaling; Cellular biology; Characteristics; Data; Defect; ERK4; ERK5; Encephalon; Encephalons; Endothelial Cells; Endothelium; Extravasation; FADK; FAK; FAK1; GFAC; Gene Delivery; Generalized Growth; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Glioma, Astrocytic; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hemato-Encephalic Barrier; Heterograft; Human; Human, Adult; Human, General; Infiltration; Injection of therapeutic agent; Injections; Intracarotid; Intracellular Communication and Signaling; Intracranial Central Nervous System Neoplasms; Intracranial Central Nervous System Tumors; Intracranial Neoplasms; Intracranial Tumor; Investigators; Isoforms; Knock-out; Knockout; Knockout Mice; L-Tyrosine; Leakage; Lung; MAPK7; MAPK7 gene; Maintenance; Maintenances; Malignant; Malignant - descriptor; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammary Cancer; Mammary Carcinoma; Mammary Neoplasms; Man (Taxonomy); Man, Modern; Mediating; Metastasis; Metastasis to the Lung; Metastasize; Metastatic Neoplasm; Metastatic Neoplasm to the Lung; Metastatic Tumor; Metastatic Tumor to the Lung; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Murine; Mus; Neoplasm Metastasis; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Null Mouse; PRKM7; PTK2; PTK2 gene; Pathway interactions; Pericapillary Cell; Pericytes; Perivascular Cell; Permeability; Phenotype; Phosphorylation; Protein Isoforms; Protein Phosphorylation; Protein-Tyrosine Kinases, src; Proteins; Regulation; Research Personnel; Researchers; Resistance; Respiratory System, Lung; Role; Rouget Cells; Sampling; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spillage; Staging; TYR; Testing; Tissue Growth; Tissues; Transplantation, Heterologous; Tumor Cell; Tumor Cell Migration; Tumors of Neuroglia; Tyrosine; Tyrosine Phosphorylation; Tyrosine, L-isomer; VEGFs; Vascular Endothelial Growth Factors; Vascular Permeabilities; Vegf; Viral; Xenograft; Xenograft Model; Xenograft procedure; Xenotransplantation; adult human (21+); base; biological signal transduction; brain metabolism; cancer metastasis; cell biology; cell type; gene product; glioblastoma multiforme; in vivo; insight; malignancy; mammary tumor; model organism; mouse model; neoplasm/cancer; neoplastic cell; novel; ontogeny; para-Tyrosine; pathway; pp125FAK; pulmonary; pulmonary metastasis; resistant; response; social role; spongioblastoma multiforme; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; tumor; tumor growth; tumors in the brain; vascular",Role of Src family kinases in endothelial cell biology,,73396,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,9,347625,
7760969,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL073525-07,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"AYALA, ALFRED ;",1864730;,5R01HL073525,09/01/2003,01/31/2012,"Acute Pulmonary Injury; Address; Adoptive Transfer; Agreement; Alveolar Macrophages; Animal Welfare; Animals; Antibodies; Apoptosis; Apoptosis Pathway; Apoptotic; Bibliography; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Body Tissues; CD11b; CD11c; CD8; CD8 Cell; CD8 lymphocyte; CD8+ T-Lymphocyte; CD8-Positive Lymphocytes; CD8-Positive T-Lymphocytes; CD8B; CD8B1; CD8B1 gene; CR3A; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular injury; Cessation of life; Characteristics; Chemosensitization; Chemosensitization/Potentiation; Circulatory Collapse; Closure by Ligation; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Corynebacterium Diphtheriae Toxin; Country; Critiques; Cytokines, Chemotactic; Data; Death; Dendritic Cells; Diphtheria Toxin; Dysfunction; Ecological impact; Editorial Comment; Editorial Comment (PT); Endothelial Cells; Endothelium; Environment; Environmental Impact; Epithelial Cells; Equipment; Ethics Committees, Research; Evaluation; Functional disorder; Genes; Hemorrhagic Shock; Heterophil Granulocyte; Homologous Chemotactic Cytokines; IACUC; INFLM; IRBs; ITGAM; ITGAM gene; ITGAX; ITGAX gene; Immune; Impact, Environmental; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Response; Inhibition of Apoptosis; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; International; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; LYT3; Ligation; Literature; Lung; Lung Injury, Acute; Lymphocyte; Lymphocytic; MAC-1; MAC1A; MO1A; Macrophage Activation; Macrophages, Alveolar; Mammals, Mice; Marrow Neutrophil; Mediating; Mice; Mice, Transgenic; Mind; Minor; Modeling; Molecular; Murine; Mus; Nature; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Organ; Peptides; Physiopathology; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Potentiation; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Published Comment; Pulmonary Macrophages; RNA, Small Interfering; Receptor Protein; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Respiratory System, Lung; Role; SIS cytokines; Series; Shock; Shock, Hemorrhagic; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Source; T-Cells; T-Lymphocyte; T8 Cells; T8 Lymphocytes; TXT; Testing; Text; Thymus-Dependent Lymphocytes; Tissues; Toxin; Transgenic Mice; Veiled Cells; Vertebrate Animals; Vertebrates; Veterans; Viewpoint; Viewpoint (PT); Work; Writing; abstracting; acute lung injury; biological signal transduction; cell damage; cell injury; chemoattractant cytokine; chemokine; circulatory shock; clinical relevance; clinically relevant; cultured cell line; cytokine; design; designing; expiration; human subject; in vivo; injured; lymph cell; macrophage; neutrophil; pathophysiology; programs; pulmonary; receptor; response; septic; siRNA; social role; thymus derived lymphocyte; vertebrata",Regulatory Mechanisms of Acute Lung Injury,,73525,ZRG1,Special Emphasis Panel,,7,386250,
7760629,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL075040-05,,NHLBI:336928;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBUS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"DOSEFF, ANDREA ;",2089689;,5R01HL075040,02/09/2006,01/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Asthma; Besnier-Boeck Disease; Biological; Biological Function; Biological Process; Biosynthetic Proteins; Blood monocyte; Boeck's Sarcoid; Bronchial Asthma; Bronchitis; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Complex; Cysteine Protease CPP32; Data; Development; Disease; Disorder; EC 2.7; Effector Cell; Family; Goals; INFLM; Immune response; Immune system; In Vitro; Inflammation; Inflammatory; Intracellular Communication and Signaling; Kinases; LPS; Label; Lead; Length of Life; Life; Lipopolysaccharides; Location; Longevity; Lung; Maps; Marrow monocyte; Modeling; Molecular; PARP Cleavage Protease; PKC; Pathogenesis; Pathway interactions; Pb element; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphoproteins; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Position; Positioning Attribute; Protein Kinase C; Protein Phosphorylation; Proteins; RNA, Small Interfering; Recombinant Proteins; Regulation; Resolution; Respiratory System, Lung; Respiratory physiology; Role; SCA-1; SREBP Cleavage Activity 1; Sarcoidosis; Schaumann's Disease; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Stimulus; Transphosphorylases; Yama; Yama protein; base; biological signal transduction; body system, allergic/immunologic; caspase-3; cysteine protease P32; disease/disorder; gene product; heavy metal Pb; heavy metal lead; host response; immunoresponse; improved; in vivo; life span; lifespan; lung function; lymphogranulomatosis; lymphogranulomatosis (benign); macrophage; member; model organism; monocyte; mutant; new therapeutic target; organ system, allergic/immunologic; pathway; pulmonary; respiratory function; siRNA; social role",Molecular Mechanisms of Apoptosis in Monocytes,,75040,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,5,336928,
7749969,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL076438-04,,NHLBI:591099;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"HUNDLEY, WILLIAM GREGORY;",6859698;,5R01HL076438,02/01/2007,12/31/2011,"1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-; Accounting; Admission; Admission activity; Affect; Age; Arts; Blood Pressure, High; Blood Vessels; Breathlessness; Cardiac Failure Congestive; Cardiac artery; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Clinical; Clinical Management; Congestive Heart Failure; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary artery; Data; Development; Diabetes Mellitus; Disease; Disorder; Dobutamine; Drugs; Dysfunction; Dyspnea; Dyspneas; Event; Exercise; Exercise, Physical; Exhibits; Functional disorder; Future; Gender; HOSP; HTRPY; Health Care Costs; Health Costs; Health Expenditures; Health Sciences; Healthcare; Healthcare Costs; Heart Decompensation; Heart Failure, Congestive; Heart Valve Diseases; Heart artery; Hospitalization; Hospitals; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; Image; Individual; Injury; Institution; Intervention; Intervention Strategies; Intravenous; Investigators; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; LV Mass; Left; Left Ventricles; Left Ventricular Function; Left Ventricular Hypertrophy; Left Ventricular Mass; Left ventricular structure; Low Cardiac Output; Lung; Magnetic Resonance; Measurement; Medication; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial Contraction; Myocardial Ischemia; Nested Case-Control Study; Organ System, Cardiovascular; Outcome; Participant; Patients; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Population; Prevalence; Procedures; Programs (PT); Programs [Publication Type]; Pulmonary Edema; Randomized Controlled Trials; Recruitment Activity; Research Design; Research Personnel; Researchers; Respiratory System, Lung; Rest; Risk; Risk Factors; Stress; Stress Tests; Stroke Volume; Study Type; Study, Nested Case-Control; Testing; Thick; Thickness; Time; Time Study; United States; Universities; Valvular Heart Diseases; Valvular Heart Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Ventricular; Ventricular Function, Left; Work; base; cardiac valve disease; cardiac valve disorder; cardiac valvular disease; cardiovascular disease risk; cardiovascular disorder risk; circulatory system; cohort; data acquisition; design; designing; diabetes; disease/disorder; drug/agent; experience; forest; health care expenditure; heart contraction; heart ischemia; heart valve disorder; high risk; hyperpiesia; hyperpiesis; hypertensive disease; imaging; information gathering; innovate; innovation; innovative; insight; interventional strategy; lung edema; myocardial ischemia/hypoxia; myocardium ischemia; novel; pathophysiology; population based; prevent; preventing; programs; prospective; pulmonary; randomized controlled study; recruit; study design; vascular",Vascular Stiffness and Pulmonary Congestion,,76438,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,4,591099,
7576833,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL077428-04,,NHLBI:543964;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LOSORDO, DOUGLAS W;",6901832;,5R01HL077428,02/01/2006,12/31/2011,"Adverse effects; Age; Alternative Therapies; Amputation; Anatomic; Anatomical Sciences; Anatomy; Arterial Obstruction; Arterial Occlusion; Artery Obstruction; Autologous; Biosynthetic Proteins; Blood; Blood Vessels; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bypass; CD34; CD34 gene; Catheters; Cell Communication and Signaling; Cell Signaling; Cell Therapy; Cells; Charcot's syndrome; Clinical; Clinical Data; Clinical Protocols; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Data; Data Set; Dataset; Diagnostic Findings; Disabled Persons; Disabled Population; Disease; Disorder; Distal; Endothelial Cells; Equilibrium; Exhibits; Extremities; FLR; Failure (biologic function); Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Intervention; Goals; HPCA1; Handicapped; Healed; Human; Human, General; Injection of therapeutic agent; Injections; Intermittent Claudication; Intervention; Intervention Strategies; Intervention, Genetic; Intracellular Communication and Signaling; Intramuscular Injections; Investigation; Investigators; Ischemia; Laboratories; Lead; Limb structure; Limbs; Lower Extremity; Lower Limb; Man (Taxonomy); Man, Modern; Mechanics; Medical; Membrum inferius; Methods and Techniques; Methods, Other; Molecular Biology, Gene Therapy; Mother Cells; Non-Trunk; Operation; Operative Procedures; Operative Surgical Procedures; Pain; Painful; Patients; Pb element; People with Disabilities; Perfusion; Peripheral arterial disease; Persons with Disabilities; Phase; Physiology; Pilot Projects; Population; Prevalence; Process; Progenitor Cells; Protocol; Protocols documentation; Recombinant Proteins; Research Personnel; Researchers; Rest; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Safety; Science of Anatomy; Seminal; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signs and Symptoms; Site; Stem cells; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Techniques; Testing; Therapeutic Agents; Therapy, Cell; Therapy, DNA; Tissues; Translating; Translatings; Treatment Side Effects; ULCN; Ulcer; Ulceration; Walking; Work; anatomy; angiogenesis therapy; artery occlusion; balance; balance function; base; biological signal transduction; cell-based therapy; claudication; clinical investigation; cytokine; design; designing; disabled; disabled people; disease/disorder; failure; gene therapy; genetic therapy; healing; heavy metal Pb; heavy metal lead; improved; insight; interventional strategy; intramuscular administration of drug; language translation; meetings; neovascularization; new therapeutics; next generation therapeutics; novel therapeutic intervention; novel therapeutics; phase 2 study; pilot study; pre-clinical; preclinical; preclinical study; randomized trial; side effect; surgery; therapeutic angiogenesis; therapy adverse effect; treatment adverse effect; vascular",Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PAD,,77428,ZRG1,Special Emphasis Panel,,4,543964,
7761763,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL077490-05,,NHLBI:352017;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,OKLAHOMA CITY,UNITED STATES,PHYSIOLOGY,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"SUN, ZHONGJIE ;",2097960;,5R01HL077490,02/01/2006,01/31/2011,"Adhesion Molecule; Aldosterone Receptor; Animal Model; Animal Models and Related Studies; Apoplexy; Area; Arts; Attenuated; BP control; Balance, Fluid; Blood Plasma; Blood Pressure; Blood Pressure, High; Blood Vessels; Body Tissues; Cardiac; Cardiac infarction; Cardiovascular Diseases; Cell Adhesion Molecules; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemotherapy-Hormones/Steroids; Chronic; Collagen; Common Rat Strains; Cortical Portion of the Kidney; Data; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; ECE-1; EDN1; ET-1; ET-1 (Endothelin-1); Endocrine Gland Secretion; Endothelin; Endothelin Receptor; Endothelin Type 1; Endothelin-1; Endothelin-converting enzyme 1; Endothelium; Endothelium-Derived Vasoconstrictor Factors; Environment; Exposure to; Fluid Balance; Goals; HTRPY; Heart; Heart Hypertrophy; Hormones; Hypertension; Hypertrophy; In Vitro; Investigators; Kidney Cortex; Laboratories; Life; MCR; MLR; Maintenance; Maintenances; Mammals, Rats; Measures; Mediating; Medication; Messenger RNA; Methods and Techniques; Methods, Other; Mineralocorticoid Receptor; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial; Myocardial Infarct; Myocardial Infarction; NR3C2; Nature; Nuclear Receptor Subfamily 3 Group C Member 2; Operation; Operative Procedures; Operative Surgical Procedures; Pathogenesis; Patients; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiology; Pilot Projects; Plasma; Play; Position; Positioning Attribute; Preproendothelin; Preproendothelin 1; Prevalence; Prevention; Preventive; Process; Production; Proendothelin-1 Precursor; Programs (PT); Programs [Publication Type]; RNA, Messenger; Rat; Rattus; Receptor Protein; Receptors, Endothelium-Derived Vasoconstrictor Factor; Regulation; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Serum, Plasma; Role; Seasons; Serum, Plasma; Severities; Stroke; Structure of cortex of kidney; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Temperature; Testing; Therapeutic; Therapeutic Hormone; Therapeutic Intervention; Thick; Thickness; Time; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vasoactive Agonists; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Weight; Work; base; blood pressure control; blood pressure homeostasis; blood pressure regulation; brain attack; cardiac hypertension; cardiac hypertrophy; cardiac infarct; cardiovascular disorder; cell adhesion protein; cerebral vascular accident; cold temperature; coronary attack; coronary infarct; coronary infarction; disease/disorder; drug/agent; endothelin-converting enzyme; expectation; genetic manipulation; heart attack; heart disease hypertension; heart disorder hypertension; heart hypertension; heart infarct; heart infarction; hyperpiesia; hyperpiesis; hypertensive cardiomyopathy; hypertensive disease; hypertensive heart disease; hypertensive heart disorder; in vivo; innovate; innovation; innovative; insight; intervention therapy; kidney cortex; low temperature; mRNA; model organism; novel; pilot study; programs; protein expression; receptor; receptor binding; receptor expression; renal cortex; response; social role; stroke; surgery; vascular; vasopressor",Intermittent Cold Exposure on the Endothelin System,,77490,HM,Hypertension and Microcirculation Study Section,,5,352017,
7758763,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL078869-05,,NHLBI:406250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,BIOCHEMISTRY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"LAYNE, MATTHEW D;",1862608;,5R01HL078869,02/01/2007,01/31/2012,"5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Angioplasty; Animals; Aortocoronary Bypass; Arterial Fatty Streak; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; BUdR; Band Shift Mobility Assay; Bandshift Mobility Assay; Binding; Binding (Molecular Function); Biology; Blood Vessels; Body Tissues; Boxing; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Carboxypeptidase; Cardiac infarction; Cell Communication and Signaling; Cell Count; Cell Differentiation; Cell Differentiation process; Cell Number; Cell Signaling; Cell-Extracellular Matrix; Cellular biology; Collagen; Complex; Contractile Proteins; Coronary Artery Bypass; Coronary Artery Bypass Grafting; Coronary Artery Bypass Surgery; Cytoskeletal Proteins; Data; Development; Disease; Disease model; Disorder; ECM; Electrophoretic Mobility Shift Assay; Elements; Exhibits; Extracellular Matrix; Extracellular Matrix Proteins; Femoral Artery; Fibrillar Collagen; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genes, LacZ; Genetic Transcription; Goals; Growth Factor Interaction; Hypercholesteremia; In Vitro; Injury; Intracellular Communication and Signaling; Investigators; Ischemia; Knockout Mice; Knowledge; LacZ; LacZ Genes; Lead; Leiomyocyte; Mammals, Mice; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Mobility Shift Assay; Modeling; Molecular; Molecular Interaction; Murine; Mus; Muscle, Smooth, Vascular; Myocardial Infarct; Myocardial Infarction; Myocytes, Smooth Muscle; Myosin Heavy Chains; Null Mouse; PDGF; PDGF-BB; Pattern; Pb element; Phenotype; Platelet-Derived Growth Factor; Prevention; Process; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Publishing; RNA Expression; Regulation; Regulatory Element; RegulatoryElement; Reporter; Research Personnel; Researchers; Role; Serum Response Factor; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Myosins; Smooth Muscle Tissue Cell; Streaks, Arterial Fatty; Structure of femoral artery; Tissues; Transcription; Transcription Factor SRF; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transfection; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uridine, 5-bromo-2'-deoxy-; Vascular Diseases; Vascular Disorder; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; biological signal transduction; blood vessel disorder; c-fos Serum Response Factor; calponin; cardiac infarct; cell biology; coronary attack; coronary bypass; coronary infarct; coronary infarction; discoidin domain receptor; discoidin receptor; disease/disorder; disorder model; experiment; experimental research; experimental study; femoral artery; gain of function; gel shift assay; gene product; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; hypercholesterolemia; in vivo; injury response; insight; intraluminal angioplasty; myosin heavy chain; neointima formation; neointimal thickening; novel; overexpression; platelet-derived growth factor BB; programs; protein expression; research study; response; response to injury; restenosis; scaffold; scaffolding; social role; transcription factor; transgene expression; vascular; vascular smooth muscle cell proliferation; vulnerable plaque",Role of ACLP in Vascular Smooth Muscle Biology,,78869,VCMB,Vascular Cell and Molecular Biology Study Section,,5,406250,
7750516,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL079166-05,,NHLBI:337565;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MEMPHIS,UNITED STATES,PHARMACOLOGY,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"OSTROM, RENNOLDS S;",7324078;,5R01HL079166,01/27/2006,12/31/2010,"15-deoxy-16-hydroxy-17-cyclobutylprostaglandin E1 methyl ester; 3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; ATP pyrophosphate-lyase (cyclizing); Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adrenergic Receptor; Adrenoceptors; Agonist; Allergic asthma; Animals; Asthma; Biochemical; Blood Coagulation Factor IV; Body Tissues; Bronchial Asthma; Ca++ element; Calcium; Caveolae; Caveolas; Cell Communication and Signaling; Cell Signaling; Cell membrane; Chemotherapy-Hormones/Steroids; Coagulation Factor IV; Collaborations; Cyclic AMP; Cyclopentaneheptanoic acid, 3-hydroxy-2-(4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl)-5-oxo-, methyl ester, (1R-(1alpha,2beta(1E,4R*),3alpha))-; Cytoplasmic Membrane; DOH-CB-PGE1; Data; Dependence; EP2 receptor; Endocrine Gland Secretion; Enzymes; Exclusion; Extrinsic asthma; Factor IV; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; GPCR Signaling; Gastrointestinal Diseases; Gastrointestinal Diseases and Manifestations; Gene Transfer; Goals; Hormones; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Investigators; Isoforms; Isoprenaline; Isopropyl Noradrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isuprel; Leiomyocyte; Lipid Rafts, Cell Membrane; M2 receptor; M3 receptor; Mammals, Mice; Measures; Mediating; Membrane Microdomains; Mice; Molecular; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinic M2 Receptor; Muscarinic M3 Receptor; Muscle Cell Contraction; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle function; Muscle relaxation phase; Muscle, Involuntary; Muscle, Smooth; Muscular Contraction; Myocytes, Smooth Muscle; Nerve Transmitter Substances; Neurotransmitters; Pathway interactions; Plasma Membrane; Play; Production; Programs (PT); Programs [Publication Type]; Prostaglandins; Prostanoids; Protein Isoforms; Receptor Protein; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Epinephrine; Receptors, Muscarinic; Regulation; Relative; Relative (related person); Relaxation; Research Personnel; Researchers; Role; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Testing; Therapeutic Hormone; Tissues; Trachea; Trachea Proper; Universities; Work; acetylcholine receptor agonist; adenoreceptor; adenosine 3'5' monophosphate; adenylcyclase; airway smooth muscle; asthmatic airway; atopic asthma; biological signal transduction; butaprost; cAMP; experience; extracellular; extrinsic allergic asthma; gastrointestinal; gastrointestinal disorder; ileum; in vivo Model; insight; lipid raft; muscle tone; mutant; new therapeutics; next generation therapeutics; novel therapeutics; overexpression; pathway; plasmalemma; programs; prostaglandin EP2 receptor; receptor; receptor coupling; respiratory smooth muscle; response; social role; transfer of a gene; treatment strategy; windpipe",Adenylyl cyclases in airway and GI smooth muscle,,79166,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,5,337565,
7780032,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL080137-05,,NHLBI:366553;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LOSORDO, DOUGLAS W;",6901832;,5R01HL080137,02/01/2006,01/31/2011,"4q Chemokine; Abbreviations; Acute; Anatomic; Anatomical Sciences; Anatomy; Apoptosis; Apoptosis Pathway; Balsams; Biological Models; Blood Precursor Cell; Blood Vessels; Body Tissues; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Bovine Species; C-X-C Chemokines; CXC Chemokines; CXC-R4; CXCL12 protein; CXCR-4; CXCR4; CXCR4 gene; Cardiac; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cattle; Cell Death, Programmed; Cells; Chemokine (C-X-C Motif) Ligand 12; Chronic; Clinical Trials; Clinical Trials, Unspecified; D2S201E; Data; Diabetes Mellitus; Disease; Disorder; EC 1.14.13.39; EDRF Synthase; Endothelial Cells; Endothelium-Derived Growth Factor Synthase; Erinaceidae; Exhibits; FB22; Fluorescence-Activated Cell Sorting; Fractionation, Fluorescence Activated Cell Sorting; Future; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes, LacZ; Genetic Intervention; Goals; Grafting, Bone Marrow; Guanylyl Cyclase-Activating Factor Synthase; HM89; HSY3RR; Hedgehogs; Hematopoietic stem cells; Homing; Human; Human, General; Intervention, Genetic; Ischemic Heart; Ischemic Heart Disease; Ischemic Preconditioning; Ischemic myocardium; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); LAP3; LCR1; LESTR; Laboratories; LacZ; LacZ Genes; Leiomyocyte; Literature; Lower Extremity; Lower Limb; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mediating; Medicine; Membrum inferius; Model System; Models, Biologic; Molecular Biology, Gene Therapy; Mononuclear; Mother Cells; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Smooth Muscle; NADPH-Diaphorase; NO Synthase; NPY3R; NPYR; NPYRL; NPYY3R; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Organ System, Cardiovascular; Outcome; PBMC; Participant; Pathologic; Peripheral Blood Mononuclear Cell; Phenotype; Physiologic; Physiological; Pre-B Cell Growth Stimulating Factor; Pre-Clinical Model; Preclinical Models; Preconditionings, Ischemic; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Receptor Protein; Recovery; Recruitment Activity; Reporting; Reticuloendothelial System, Bone Marrow; Retina; Retina Neoplasm; Retinal Neoplasms; Role; SDF-1; SDF-1alpha; Science of Anatomy; Science of Medicine; Sdf1 protein; Series; Site; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Sortings, Fluorescence-Activated Cell; Stem cells; Stromal Cell-Derived Factor 1; Structure; Testing; Therapeutic; Therapy, DNA; Tissues; Transplantation; Tumor Tissue; Tumor of the Retina; Tumors, Retinal; Umbilical vein; VEGFs; Vascular Endothelial Growth Factors; Vascular, Heart; Vegf; Wound Healing; Wound Repair; alpha-Chemokines; anatomy; angiogenesis therapy; beta-D-Galactosidase; beta-D-Galactoside galactohydrolase; beta-Galactosidase; bovid; bovine; cardiac infarct; cardiac muscle; cell type; circulatory system; clinical investigation; coronary attack; coronary infarct; coronary infarction; cow; design; designing; diabetes; disease/disorder; experiment; experimental research; experimental study; gene therapy; genetic therapy; hIRH; heart attack; heart infarct; heart infarction; heart ischemia; heart muscle; improved; in vitro Model; in vivo; lac Z Protein; macrophage; myocardial ischemia/hypoxia; myocardium ischemia; neovascularization; progenitor; programs; receptor; recruit; repair; repaired; research study; response; restenosis; social role; stromal cell-derived factor-1alpha; therapeutic angiogenesis; tissue repair; transplant; tumor; vascular",Role of Progenitor Cells in Cardiovascular Medicine,,80137,MIM,Myocardial Ischemia and Metabolism Study Section,,5,366553,
7765544,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL080518-05,,NHLBI:367244;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,ENGINEERING (ALL TYPES),53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"CHIEN, SHU ;",1880613;,5R01HL080518,02/01/2006,01/31/2011,"Apoptosis; Apoptosis Pathway; Arteries; Autoregulation; Bears; Biological Function; Biological Process; Cell Communication and Signaling; Cell Components; Cell Culture Techniques; Cell Death, Programmed; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Structure; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Cellular Stress; Cellular Structures; Cytometry; Endothelial Cells; Endothelium; Event; Extracellular Signal-Regulated Kinase Gene; Feedback; Fiber; Figs; Figs - dietary; Generations; Homeostasis; In Vitro; Ink; Intracellular Communication and Signaling; MAP Kinase Gene; MAPK; Magnetism; Measurement; Measures; Mechanics; Mitogen-Activated Protein Kinase Gene; Modeling; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Myosin Light Chains; Pathway interactions; Phosphorylation; Physiological Homeostasis; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Protein Phosphorylation; Research; Rho-associated kinase; Rho-kinase; Role; Signal Transduction; Signal Transduction Systems; Signaling; Small G-Proteins; Small GTPases; Stress Fibers; Stretching; Subcellular Process; System; System, LOINC Axis 4; Testing; Time; Ursidae; Ursidae Family; Vascular Endothelial Cell; base; biological signal transduction; design; designing; experiment; experimental research; experimental study; insight; magnetic; particle; pathway; pressure; research study; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; social role",Mechanical Feedback on Cell Structure and Signaling,,80518,VCMB,Vascular Cell and Molecular Biology Study Section,,5,367244,
7754424,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL080624-04,,NHLBI:396250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BUFFALO,UNITED STATES,BIOCHEMISTRY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"GRONOSTAJSKI, RICHARD M;",1898968;,5R01HL080624,03/03/2007,01/31/2012,"Address; Affect; Alleles; Allelomorphs; Binding; Binding (Molecular Function); Biochemical; Biochemical Genetics; Biochemical Pathway; Birth; Body Tissues; CCAAT-Box Binding Transcription Factor; CTF; Candidate Disease Gene; Candidate Gene; Cells; Defect; Development; Epithelial; Epithelial Cells; Epithelium; FLR; Failure (biologic function); Family; Family member; Fetal Lung; Fibroblasts; Gene Expression; Gene Targeting; Generalized Growth; Generations; Genes; Genetic; Genetic, Biochemical; Genomics; Glucocorticoids; Grant; Growth; Human; Human, General; In Vitro; Infant, Premature; Knock-out; Knockout; Knockout Mice; Lung; Lung diseases; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical; Mesenchymal; Mesenchymas; Mesenchyme; Metabolic Networks; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Murine; Mus; NF-I Protein; NF-I/B; NF-IB; NF-IB Protein; NF1-B; NFI; NFI Transcription Factor; NFI-B; NFI-RED; NFIB; NFIB protein, human; NFIB2; NFIB3; Nuclear Factor 1 B-Type; Nuclear Factor I; Nuclear Factor I/B; Null Mouse; Organ; Parturition; Pathway interactions; Perinatal; Phenotype; Population; Premature Infant; Property; Property, LOINC Axis 2; Proteins; Pulmonary Diseases; Pulmonary Disorder; Regulatory Element; RegulatoryElement; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory physiology; Role; Staging; System; System, LOINC Axis 4; TGGCA-Binding Protein; Targetings, Gene; Testing; Therapeutic Glucocorticoid; Time; Tissue Growth; Tissues; cell type; failure; gene product; human NFIB protein; insight; lung development; lung disorder; lung function; lung maturation; novel; nuclear factor 1; nuclear factor I/B protein, human; ontogeny; pathway; postnatal; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; prevent; preventing; pulmonary; respiratory function; social role; standard care; transcription factor",Roles of NFI Genes in Mouse Lung Development,,80624,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,4,396250,
7762718,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL080682-04,,NHLBI:371250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW ORLEANS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,053785812,US,LA,70118,TULANE UNIVERSITY OF LOUISIANA,"DELAFONTAINE, PATRICE ;",6882897;,5R01HL080682,01/15/2007,12/31/2011,"1-Phosphatidylinositol 3-Kinase; 20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 70-kDa Ribosomal Protein S6 Kinases; AFBP; ANG-(1-8)Octapeptide; APF-1; ATP-Dependent Proteolysis Factor 1; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Abbreviations; Actins; Age; Agglutinins; Aldosterone; Alpha-Pregnancy-Associated Endometrial Globulin; Amniotic Fluid Binding Protein; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensin-Forming Enzyme; Angiotensinogenase; Anterior Descending Coronary Artery; Antimorphic mutation; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Atrophic; Atrophy; Atrophy, Muscle; Autocrine Systems; Binding Protein-25; Binding Protein-26; Binding Protein-28; Body Weight; Boxing; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cardiac Failure Congestive; Cardiac artery; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cells; Chronic; Closure by Ligation; Common Rat Strains; Congestive Heart Failure; Coronary artery; Cysteine Protease CPP32; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; ELISA; Electroporation; Enzyme-Linked Immunosorbent Assay; F Box; F Box Domain; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fiber; Gene Transfer; Grant; Growth Hormone Independent-Binding Protein; HMG-20; Heart Decompensation; Heart Failure, Congestive; Heart artery; Heart failure; High Mobility Protein 20; Humulin R; IBP-1; ICE-like protease; IGF-1; IGF-1 Receptor; IGF-Binding Protein 1; IGF-Binding Protein 3; IGF-Binding Protein 5; IGF-I; IGF-I-SmC; IGF1; IGF1R; IGFBP-1; IGFBP-3; IGFBP-5; IGFBP1; IGFBP3; IGFBP5; Infusion; Infusion procedures; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor 1 Receptor; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Insulin-Like Growth-Factor Binding Protein 1; Insulin-Like Somatomedin Peptide I; Insulin-Like-Growth Factor I Receptor; Intracellular Communication and Signaling; Investigators; Isoforms; L-Serine; Left; Ligation; Macropain; Macroxyproteinase; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Mediating; Mice; Modeling; Molecular; Mononuclear; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mother Cells; MuRF1 protein; Multicatalytic Proteinase; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Myocytes; Novolin R; Organ System, Cardiovascular; Outcome; PARP Cleavage Protease; PI-3 Kinase; PI-3K; PI3-Kinase; PP12; Pathway interactions; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Plasmids; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Pressure; Pressure- physical agent; Prevention; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Proteasome Inhibition; Protein Cleavage; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Isoforms; Protein Phosphorylation; Protein Turnover; Proteins; Proteolysis; Proteosome; PtdIns 3-Kinase; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Rat; Rattus; Receptor, IGF Type 1; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor Type 1; Renin; Renin-Angiotensin-Aldosterone System; Research Personnel; Researchers; Ribosomal Protein S6 Kinases, 70-kDa; Rodent; Rodentia; Rodentias; Role; SCA-1; SREBP Cleavage Activity 1; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Somatomedin C; Stem cells; Superoxide Anion; Superoxide Radical; Superoxides; System; System, LOINC Axis 4; System, Renin-Angiotensin-Aldosterone; Transgenes; Transgenic Organisms; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Ubiquitin; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Vascular, Heart; Vent; Yama; Yama protein; autocrine; base; biological signal transduction; cardiac failure; caspase; caspase-3; circulatory system; constriction; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; disease/disorder; gene product; human FRAP1 protein; insight; mTOR; multicatalytic endopeptidase complex; muscle RING finger 1; new therapeutics; next generation therapeutics; novel; novel therapeutics; overexpression; p70 S6 Kinase; p70s6k; pathway; placental protein 12; pressure; prevent; preventing; programs; protein degradation; rapamycin and FKBP12 target 1 protein, human; ring finger protein 28; satellite cell; social role; stem; transcription factor; transfer of a gene; transgenic; ubiquitin ligase; wasting","Angiotensin II, IGF-1 and Skeletal Muscle Atrophy",,80682,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,4,371250,
7569404,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL081186-04,,NHLBI:377500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MINNEAPOLIS,UNITED STATES,PEDIATRICS,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"KYBA, MICHAEL ;",8140830;,5R01HL081186,01/18/2007,12/31/2011,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; 21+ years old; Adult; Alleles; Allelomorphs; Amino Acid Sequence; Blood; Blood (Leukemia); Blood Precursor Cell; Bone Marrow Transplant; Bone Marrow Transplantation; Candidate Disease Gene; Candidate Gene; Cell Count; Cell Line; Cell Lines, Strains; Cell Number; CellLine; Cells; Chimera Protein; Chimeric Proteins; Code; Coding System; Data; Development; Doxycycline; ES Cell Line; ES cell; Elements; Embryo; Embryonic; Embryonic Stem Cell Line; Engineering; Engineerings; Engraftment; Evolution; Fusion Protein; Gene Family; Gene Targeting; Genes; Goals; Grafting, Bone Marrow; Hematologic Body System; Hematopoietic; Hematopoietic Body System; Hematopoietic System; Hematopoietic stem cells; Human, Adult; In Vitro; Investigators; Leukemias, General; Lymphoid; Mammals, Mice; Marrow Transplantation; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Molecular; Molecular Biology, Protein Sequencing; Mother Cells; Murine; Mus; Myelogenous; Myeloid; Organ System, Hematologic; Pattern; Peptide Domain; Peptide Sequence Determination; Population; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Programs (PT); Programs [Publication Type]; Protein Domains; Protein Sequencing; Protein Structure, Primary; Research Personnel; Researchers; Reticuloendothelial System, Blood; Role; Self-Help Groups; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Source; Stem cells; Support Groups; System; System, LOINC Axis 4; Targetings, Gene; Tertiary Protein Structure; Testing; Translating; Translatings; Transplantation; Vibramycin; Work; adult human (21+); alpha-6-Deoxyoxytetracycline; base; cultured cell line; daughter cell; embryonic stem cell; experiment; experimental research; experimental study; gain of function; in vitro Assay; insight; language translation; leukemia; loss of function; member; overexpression; paralog; paralogous gene; programs; protein sequence; research study; response; retroviral transduction; self help organization; self-renewal; social role; stem cell division; stem cell of embryonic origin; transplant",Probing the Hematopoietic Hox Code,,81186,HP,Hematopoiesis Study Section,,4,377500,
7415172,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL081380-03,,NHLBI:577165;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"FRIEDMAN, ROBERT H;",1886754;,5R01HL081380,07/01/2006,12/31/2011,"Active Follow-up; Affect; American Heart Association; Area; Arm; Behavior; Behavioral; Booklets; Boston; Brochures; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cessation of smoking; Characteristics; City of Boston; Communication; Computers; Consumption; Control Groups; Diet; Dietary Intervention; Digit; Digit structure; Dimensions; Disease; Disorder; Eating; Effectiveness; Effectiveness of Interventions; Evaluation; Food Intake; Fruit; Goals; Health Care Professional; Health Professional; Health behavior; Health behavior change; Health profession; Healthcare professional; Healthcare worker; Individual; Intake; Internet; Intervention; Intervention Strategies; Investigation; Investigators; Link; Maintenance; Maintenances; Mediation; Medical center; Modality; Modeling; Negotiating; Negotiation; Nutrition; Nutrition Interventions; Nutritional Interventions; Nutritional Science; On-Line Systems; Online Systems; Organ System, Cardiovascular; Outcome; Pamphlets; Pathway interactions; Patients; Perception; Persons; Phone; Population; Prevalence; Printing; Programs (PT); Programs [Publication Type]; Public Health; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Research Personnel; Researchers; Rhode Island; Sampling; Schools; Science of nutrition; Secondary Prevention; Severities; Sound; Sound - physical agent; Structure; Study Subject; System; System, LOINC Axis 4; TXT; Technology; Telecommunications; Telephone; Testing; Text; Time; Trials, Randomized Clinical; Universities; Upper arm; Vascular, Heart; WWW; base; behavior change; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cease smoking; circulatory system; communication theory; comparative efficacy; cost; design; designing; dietary fruit; disease/disorder; effect of intervention; follow-up; fruits and vegetables; improved; instrument; intervention design; intervention effect; interventional strategy; nutrition; online computer; pathway; population based; programs; public health medicine (field); randomisation; randomization; randomly assigned; recruit; saturated fat; smoking cessation; sound; theories; therapy design; treatment design; web; web based; world wide web",Improving Dietary Behavior Through Tailored Messages,,81380,PRDP,Psychosocial Risk and Disease Prevention Study Section,,3,577165,
7759616,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL081569-05,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"RADICE, GLENN LAWRENCE;",1900593;,5R01HL081569,02/15/2007,01/31/2012,"A Mouse; Actins; Adherens Junction; Adhering Junction; Adhesive Junction; Adhesives; Alleles; Allelomorphs; Anchoring Junction; Animals; Anti-Arrhythmia Agents; Anti-Arrhythmia Drugs; Anti-Arrhythmics; Antiarrhythmia Agents; Antiarrhythmia Drugs; Antiarrhythmic Drugs; Arrhythmia; Arrhythmogenic Right Ventricular Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia; Binding; Binding (Molecular Function); Body Tissues; Cadherins; Cardiac; Cardiac Arrhythmia; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cardiomyopathies; Cardiomyopathy, Dilated; Cell Adhesion; Cell membrane; Cell-Cell Adhesion; Cellular Adhesion; Cellular Matrix; Communicating Junction; Complex; Congestive Cardiomyopathy; Connexin 43; Connexin43; Coupling; Cx43; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Death, Sudden; Death, Sudden, Cardiac; Defect; Desmoplakin III; Development; Dilated Cardiomyopathy; Disease; Disorder; Exhibits; Family; Gap Junctions; Gene Targeting; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; HTRPY; Heart Arrhythmias; Heart Diseases; Heart myocyte; Herpes Zoster; Herpes zoster disease; Heterozygote; Hypertrophy; Incidence; Intercalated disc; Investigators; Ischemia; JUP; Junction Plakoglobin; Knock-out; Knockout; Knockout Mice; Knowledge; Lead; Length of Life; Liver Cell Adhesion Molecules; Longevity; Low-resistance Junction; Maintenance; Maintenances; Mammals, Mice; Mechanics; Mediating; Methods; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Molecular Target; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes; Myocytes, Cardiac; N-Cadherin; Nexus; Nexus Junction; Null Mouse; Pathway interactions; Patients; Pb element; Persons; Phenotype; Plasma Membrane; Play; Property; Property, LOINC Axis 2; Research; Research Personnel; Researchers; Risk; Role; Screening procedure; Shingles; Stress; Structure; Sudden Death; Targetings, Gene; Testing; Tissues; United States; Ventricular; Work; Zona; Zoster; adhesion receptor; antiarrhythmic agent; arrhythmic agent; cardiac muscle; cardiomyocyte; design; designing; disease/disorder; experiment; experimental research; experimental study; gamma catenin; genome mutation; heart disorder; heart muscle; heavy metal Pb; heavy metal lead; herpes zona; insight; intracellular skeleton; life span; lifespan; liver cell adhesion molecule; loss of function; mouse model; mutant; myocardium disorder; novel; pathway; plakoglobin; plasmalemma; research study; screening; screenings; social role",Cadherin/Catenin Function in Arrhythmogenesis,,81569,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,5,386250,
7762730,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL081700-04,,NHLBI:372013;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,BIOCHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"CHEN, JAU-NIAN ;",6978369;,5R01HL081700,02/01/2007,01/31/2011,"ATP phosphohydrolase (Na+ K+ transporting); Address; Affect; Animal Model; Animal Models and Related Studies; Ankyrins; Architecture; Bilateral; Binding; Binding (Molecular Function); Biochemical; Biological Function; Biological Process; Body Tissues; Brachydanio rerio; Cardiac; Cardiac Myocytes; Cardiocyte; Cell Communication and Signaling; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Shape; Cell Signaling; Cellular Matrix; Cellular Proliferation; Critical Paths; Critical Pathways; Cultured Cells; Cytoskeletal System; Cytoskeleton; DNA Sequence Rearrangement; Danio rerio; Data; Defect; Development; Developmental Process; Embryo; Embryonic; Embryonic Heart; Engineering / Architecture; Event; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Goals; Growth; Health; Heart; Heart myocyte; Hour; Human; Human, General; Intracellular Communication and Signaling; Investigators; Lead; Lesion; Life; Man (Taxonomy); Man, Modern; Mind; Molecular; Molecular Genetic; Molecular Genetics; Molecular Interaction; Morphogenesis; Muscle Cells, Cardiac; Muscle Cells, Heart; Mutation; Myocardial; Myocytes, Cardiac; N-terminal; NH2-terminal; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Na+ K+ ATPase; Nature; Pattern; Pb element; Phenotype; Potassium Pump; Process; Processed Genes; Proteins; Rearrangement; Reporting; Research Personnel; Researchers; Riots; Role; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump; Structure; Time; Tissue Growth; Tissues; Tube; Tubular; Tubular formation; Vertebrate Animals; Vertebrates; Zebra Danio; Zebra Fish; Zebrafish; biological signal transduction; cardiogenesis; cardiomyocyte; clinical relevance; clinically relevant; embryo cell culture; embryonic cell culture; experiment; experimental research; experimental study; gene function; gene product; genome mutation; heart development; heavy metal Pb; heavy metal lead; insight; intracellular skeleton; loss of function; model organism; mutant; ontogeny; positional cloning; research study; reverse genetics; social role; sodium potassium exchanging ATPase; success; vertebrata",Patterning of the Primitive Heart Tube in Zebrafish,,81700,CDD,Cardiovascular Differentiation and Development Study Section,,4,372013,
7752781,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL081825-06,,NHLBI:364125;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"KIM, KWANG CHUL;",1902079;,5R01HL081825,02/03/2006,12/31/2010,"3-10C; AMCF-I; ATP-protein phosphotransferase; Abbreviations; Accounting; Adaptor Protein; Adaptor Signaling Protein; Agrin; Air; Airway Obstruction; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antimorphic mutation; Attenuated; Binding; Binding (Molecular Function); Binding Proteins; Binding Sites; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Blotting, Far-Western; Blotting, West-Western; Boxing; Bronchioalveolar Lavage; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; CD62E Antigens; CF airway; CHO Cells; CXCL8; Cachectin; Cachectin-Tumor Necrosis Factor; Causality; Cell Adhesion Molecule E-Selectin; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell Surface Receptors; Cells; Chimera Protein; Chimeric Proteins; Chinese Hamster Ovary Cell; Co-Immunoprecipitations; Combining Site; Cricetinae; Cystic Fibrosis; Cytoplasmic Domain; Cytoplasmic Tail; Deletion Mutagenesis; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; E-Selectin; EC 2.7; EC 2.7.2-; EGF; EGF gene; EGFR; ELAM-1; ERBB Protein; ERBB1; ERK MAP Kinases; Endothelial Adhesion Molecule 1; Endothelial Leukocyte Adhesion Molecule-1; Engineering; Engineerings; Enterokinase; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epithelial; Epithelial Cells; Etiology; Exhibits; External Domain; Extracellular Domain; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Far-Western Blotting; Far-Western Blottings; Flagella; Flagellin; Fusion Protein; GCP-1; GCP1; GFAC; Genetics-Mutagenesis; Genital System, Female, Ovary; Glycoproteins; Gray; Gray unit of radiation dose; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HER1; Hamsters; Heterophil Granulocyte; IL-8; IL8; IL8 gene; INFLM; Immune Precipitation; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunoprecipitation; Individual; Infection; Inflammation; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; K60; Kinases; Kinetic; Kinetics; Knock-out; Knockout; Knockout Mice; LECAM-2; LECT; LUCT; LYNAP; Label; Laboratories; Lavage, Bronchopulmonary; Leu-CAM Receptor Family; Leukocyte Adhesion Molecules; Leukocyte Endothelial Cell Adhesion Molecule 2; Leukocyte-Adhesion Receptor Family; Leukocyte-Adhesion Receptors; Leukocytes; Ligand Binding Protein; Liquid substance; Lung; Lung Lavage; Lung diseases; MAP Kinase 8; MAP Kinase Kinases; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MAPK Kinases; MAPK8 Mitogen-Activated Protein Kinase; MAPKKs; MDNCF; MEKs; MONAP; MTGN; MUC1; Malignant Cell; Mammals, Hamsters; Mammals, Mice; Marrow Neutrophil; Marrow leukocyte; Mediating; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Molecular Biology, Mutagenesis; Molecular Interaction; Molecules, Leukocyte Adhesion; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucin-1 Staining Method; Mucins; Mucous body substance; Mucoviscidosis; Mucus; Mucus Glycoprotein; Murine; Mus; Mutagenesis; NAF; Natural Immunity; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Ovary; P. aeruginosa; P.aeruginosa; Pathway interactions; Patients; Phenotype; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phosphorylation; Phosphotransferases; Physiologic; Physiological; Plasmid Cloning Vector; Plasmid Vector; Pneumonia; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Protein Kinase; Protein Phosphorylation; Pseudomonas aeruginosa; Pseudomonas pyocyanea; PtdIns; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; RNA, Small Interfering; Reactive Site; Receptor Cross-Talk; Receptor Protein; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Cell Surface; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Leukocyte-Adhesion; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SCYB8; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Staging; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Surface; System; System, LOINC Axis 4; TIL3; TLR protein; TLR5; TLR5 gene; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TSG-1; Tandem Repeat Sequences; Tandem Repeats; Testing; Thick; Thickness; Threonine/Tyrosine Protein Kinase; Toll-like receptors; Transfection; Transforming Growth Factor alpha Receptor; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; URG; West-Western Blottings; White Blood Cells; White Cell; Wild Type Mouse; b-ENAP; base; biological signal transduction; bronchopulmonary lavage therapy; c-erbB-1; c-erbB-1 Protein; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cancer cell; cystic fibrosis airway; cytokine; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; endothelial leukocyte adhesion molecule; enteropeptidase; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; extracellular; extracellular signal related kinase; fluid; glycogen synthase a kinase; hydroxyalkyl protein kinase; in vivo; inhibitor; inhibitor/antagonist; insight; jun-NH2-Terminal Kinase; knockout animal; leukocyte adhesion molecule; liquid; lung disorder; macrophage; mucous; mutant; neutrophil; novel; pathogen; pathway; phosphorylase b kinase kinase; programs; proto-oncogene protein c-erbB-1; pulmonary; receptor; research study; response; siRNA; social role; sperm protein; stress activated protein kinase; stress-activated protein kinase 1; theories; tumor necrosis factor (unspecified); white blood cell; white blood corpuscle",Anti-inflammatory role of MUC1 mucin,,81825,ZRG1,Special Emphasis Panel,,6,364125,
7770825,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL081860-02,,NHLBI:366900;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,PHARMACOLOGY,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"SOWA, GRZEGORZ ;",7643238;,5R01HL081860,02/15/2009,01/31/2013,"Affect; Angiogenesis, Pathologic; Angiogenesis, Pathological; Angiogenesis, Physiologic; Angiogenesis, Physiological; Blood Vessels; Blood capillaries; Body Tissues; CAV2; Cancers; Capillaries; Capillary; Capillary Endothelial Cell; Capillary, Unspecified; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Caveolae Protein, 20-kD; Cell Adhesion; Cell Communication and Signaling; Cell Cycle Progression; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Growth in Number; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell physiology; Cellular Adhesion; Cellular Function; Cellular Physiology; Cellular Process; Cellular Proliferation; Collagen; Data; Endothelial Cell, Capillary; Endothelial Cells; Extracellular Matrix, Integrins; GFAC; Gel; Generalized Growth; Goals; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Growth and Development; Growth and Development function; Human; Human, General; In Vitro; Injury; Integrins; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Knowledge; L-Serine; L-Tyrosine; Lung; Lung diseases; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane Proteins; Membrane-Associated Proteins; Mice; Mice, Knock-out; Mice, Knockout; Mitotic; Molecular; Morphogenesis; Murine; Mus; N-terminal; NH2-terminal; Neovascularization, Pathological; Neovascularization, Physiologic; Neovascularization, Physiological; Null Mouse; Organ System, Cardiovascular; Pathologic Neovascularization; Phase; Phenotype; Phosphorylation; Phosphorylation Site; Physiologic; Physiologic Neovascularization; Physiological; Process; Proliferating; Protein Phosphorylation; Pulmonary Diseases; Pulmonary Disorder; RNA, Small Interfering; Research; Research Proposals; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Structure; Subcellular Process; Surface Proteins; System; System, LOINC Axis 4; TYR; Testing; Tissue Growth; Tissues; Tumor Cell; Tyrosine; Tyrosine Phosphorylation; Tyrosine, L-isomer; Vascular, Heart; Work; Wound Healing; Wound Repair; angiogenesis; base; biological signal transduction; capillary; caveolin-2; cell type; circulatory system; implantation; in vitro Model; in vivo; lung disorder; malignancy; matrigel; migration; mutant; neoplasm/cancer; neoplastic cell; ontogeny; para-Tyrosine; postnatal; public health relevance; pulmonary; siRNA; social role; subcutaneous; tissue repair; tumor; tumor growth; vascular",Caveolin-2 and Endothelial Cell Function," Project Narrative The overall goal of this research proposal is to understand the role of the membrane protein called caveolin-2 in regulating endothelial cell proliferation, differentiation and their combined contribution to angiogenesis. Angiogenesis is the process of new blood vessel formation, which is essential for physiological growth, development, wound healing, as well as pathological tumor growth. Thus, understanding the molecular mechanisms controlling angiogenesis is of key significance. The knowledge gained from this research will facilitate the treatment of cardiovascular and pulmonary disease, injuries, and cancer.",81860,VCMB,Vascular Cell and Molecular Biology Study Section,,2,366900,
7755006,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL082772-04,,NHLBI:366250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LEXINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"TANNOCK, LISA R;",3127449;,5R01HL082772,02/15/2007,01/31/2012,"AGTR2; AGTR2 gene; AT2; Angiotensins; Animals; Apo-B; ApoB; Apolipoproteins; Apolipoproteins B; Apoplexy; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Bgn protein; Binding; Binding (Molecular Function); Blood Vessels; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical Trials; Clinical Trials, Unspecified; Data; Death; Development; Diabetes Mellitus; Employee Strikes; Event; Foam Cells; Goals; Grant; High Prevalence; Human; Human, General; In Vitro; Infusion; Infusion procedures; Intervention; Intervention Strategies; Investigators; Kidney Failure; Kidney Insufficiency; LDL; Leiomyocyte; Link; Lipoproteins; Lipoproteins, LDL; Low-Density Lipoproteins; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Modeling; Molecular Interaction; Murine; Mus; Myocardial Infarct; Myocardial Infarction; Myocytes, Smooth Muscle; Organ System, Cardiovascular; OxLDL; PG-S1; Peptides; Play; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteoglycan; Receptor Protein; Relative; Relative (related person); Renal Failure; Renal Insufficiency; Renin-Angiotensin System; Research Personnel; Researchers; Risk; Risk Factors; Role; Saline; Saline Solution; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Strikes; Strikes, Employee; Stroke; Testing; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Vascular Accident, Brain; Vascular, Heart; atheromatosis; atherosclerotic vascular disease; beta-Lipoproteins; biglycan; bone proteoglycan I; brain attack; cardiac infarct; cardiovascular disorder; cerebral vascular accident; circulatory system; clinical investigation; coronary attack; coronary infarct; coronary infarction; diabetes; experiment; experimental research; experimental study; heart attack; heart infarct; heart infarction; in vivo; interventional strategy; macrophage; mouse model; novel; ox-LDL; oxidation; oxidized LDL; oxidized low density lipoprotein; prevent; preventing; programs; protective effect; proteoglycan I; proteoglycan S1; receptor; research study; response; social role; stroke; vascular",Angiotensin Induced Proteoglycans in Atherosclerosis,,82772,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,4,366250,
7760985,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL082846-05,,NHLBI:292270;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAMPAIGN,UNITED STATES,PHYSIOLOGY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"XIANG, YANG ;",8244752;,5R01HL082846,02/01/2006,01/31/2011,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; ADRGND; Address; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenoviridae; Adenoviruses; Adrenal Glands; Adrenaline; Adrenals; Adrenergic Receptor; Adrenoceptors; Agonist; Animals; Apoptosis; Apoptosis Pathway; Behavior; Binding; Binding (Molecular Function); Biochemical; Biological Models; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiovascular Diseases; Cardiovascular Physiology; Catecholamines; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chronic; Chronotropism, Cardiac; Chronotropisms, Cardiac; Complex; Coupling; Cyclic AMP-Dependent Protein Kinases; Degradation Pathway; Degradative Pathway; Drug Design; Effects, Longterm; Epi; Epinephrine; Fear; Fright; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Genes; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heart; Heart Rate; Heart failure; Heart myocyte; Intracellular Communication and Signaling; Kinetic; Kinetics; Knock-out; Knockout; Knockout Mice; Levarterenol; Levonorepinephrine; Life; Ligand Binding; Ligands; Long-Term Effects; Mammals, Mice; Measurement; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Modification; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Myocytes; Myocytes, Cardiac; Neonatal; Noradrenaline; Norepinephrine; Null Mouse; PKA; Phosphorylation; Property; Property, LOINC Axis 2; Protein Kinase A; Protein Phosphorylation; Proteins; Receptor Protein; Receptor Signaling; Receptors, Epinephrine; Regulation; Relative; Relative (related person); Role; SNS; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Structure; Sympathetic Nervous System; Sympathins; Therapeutic Epinephrine; Ubiquitilation; Ubiquitination; Ubiquitinoylation; Yang; adenoreceptor; biological signal transduction; cAMP-Dependent Protein Kinases; cardiac failure; cardiomyocyte; cardiovascular disorder; cardiovascular function; cell imaging; cell type; cellular imaging; clinical applicability; clinical application; clinical relevance; clinically relevant; conformation; conformational state; density; desensitization; gene product; in vivo; mutant; receptor; receptor recycling; response; social role; suprarenal gland; trafficking; ubiquination; ubiquitin conjugation",BETA1 AND BETA2 ADRENOCEPTOR SIGNALING IN CARDIAC MYOCYTE,,82846,MIM,Myocardial Ischemia and Metabolism Study Section,,5,292270,
7758824,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL082896-04,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"COHEN, JONATHAN C;",1870384;,5R01HL082896,02/01/2007,01/31/2012,"Address; Aged 65 and Over; Allele Frequency; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Bioassay; Biologic Assays; Biological Assay; Blood; Blood Plasma; Blood Pressure; Blood Pressure, High; C-reactive protein; Cause of Death; Cholest-5-en-3-ol (3beta)-; Cholesterol; Communities; Complex; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary heart disease; Country; DNA Sequence; Data; Development; Diabetes Mellitus; Disease; Disorder; Dyslipidemias; Elderly; Elderly, over 65; Epidemiology, Family Medical History; Family Medical History; Family history of; GWAS; Gene Frequency; Genes; Genetic; Genetic Determinism; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genome, Human; Genomics; Goals; Grant; Heart; Heterogeneity; Human Genome; Hypertension; Inherited Predisposition; Inherited Susceptibility; Insulin Resistance; Investigators; Lipids; Lipoproteins; Maps; Measures; Methods; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Pathogenesis; Pathway interactions; Phenotype; Plasma; Polymorphism (Genetics); Polymorphism, Genetic; Population; Predisposition; Prevention; Programs (PT); Programs [Publication Type]; Proprotein Convertases; Proteins, specific or class, C-reactive; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; SNP Map; Sampling; Screening procedure; Serum, Plasma; Single Nucleotide Polymorphism Map; Smoking; Susceptibility; Testing; Variant; Variation; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; advanced age; allelic frequency; atheromatosis; atherosclerotic vascular disease; cardiovascular risk; cardiovascular risk factor; case control; cohort; coronary disorder; density; diabetes; disease phenotype; disease/disorder; elders; gene function; genetic determinant; genetic etiology; genetic mechanism of disease; genetic vulnerability; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; geriatric; hyperpiesia; hyperpiesis; hypertensive disease; insulin resistant; late life; later life; meetings; new therapeutic target; novel; older adult; older person; pathway; polymorphism; population based; premature; programs; screening; screenings; senior citizen; whole genome association studies; whole genome association study",Genetic Determinants of Coronary Atherosclerosis,,82896,CASE,Cardiovascular and Sleep Epidemiology Study Section,,4,392500,
7755016,R01,HL,5,,01/27/2010,12/31/2010,,5R01HL082927-04,,NHLBI:382500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"AIRD, WILLIAM C;",2085483;,5R01HL082927,01/19/2007,12/31/2010,"Adhesion Molecule; Adhesions; Animal Model; Animal Models and Related Studies; Animals; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Attenuated; Autoregulation; Avastin; BB2; Band Shift Mobility Assay; Bandshift Mobility Assay; Blood Vessels; Blood leukocyte; Body Tissues; CD106; CD106 Antigens; CD54; CD54 (ICAM 1); CD54 Antigens; CHIP assay; Cancers; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; ChIP (chromatin immunoprecipitation); Clotting; Coagulation; Coagulation Process; Coupled; DNA-Protein Interaction; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Electrophoretic Mobility Shift Assay; Endothelial Cells; Endothelium; Foundations; Gene Delivery; Gene Expression; Gene Proteins; Gene Targeting; Gene Transcription; Genes; Genetic Transcription; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Goals; Harvest; Health; Heart; Hemostasis; Hemostatic function; Homeostasis; Human; Human, General; ICAM-1; ICAM-1 Gene; ICAM1; ICAM1 gene; INCAM-110; INFLM; Immunoglobulin Enhancer-Binding Protein; Inducible Cell Adhesion Molecule 110; Inflammation; Inflammatory; Intercellular adhesion molecule 1; Intracellular Communication and Signaling; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Knockout Mice; Lead; Leukocytes; Link; Lung; MTGN; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Marrow leukocyte; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Microvascular Permeability; Mitogens; Mobility Shift Assay; Modality; Modeling; Murine; Mus; Myocardial Ischemia; NADPH Oxidase; NF-AT proteins; NF-kB; NF-kappa B; NF-kappaB; NFAT proteins; NFATC proteins; NFKB; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Pathway interactions; Pattern; Pb element; Permeability; Phenotype; Physiological Homeostasis; Play; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Protein Gene Products; RNA Expression; RNA, Small Interfering; Research Personnel; Researchers; Respiratory System, Lung; Reticuloendothelial System, Leukocytes; Role; Sentinel; Sepsis; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Subcellular Process; Targetings, Gene; Testing; Therapeutic; Time; Tissues; Transact; Transcription; Transcription Factor NF-kB; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transgenic Organisms; VCAM; VCAM-1; VEGF Receptors; VEGFR; VEGFs; VPF Receptor; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vegf; White Blood Cells; White Cell; Wild Type Mouse; Wound Healing; Wound Repair; angiogenesis; biological signal transduction; blood vessel disorder; bloodstream infection; cell adhesion protein; chromatin immunoprecipitation; disease/disorder; experiment; experimental research; experimental study; gel shift assay; heart ischemia; heavy metal Pb; heavy metal lead; in vivo; insight; intervention development; intraperitoneal; kappa B Enhancer Binding Protein; malignancy; model organism; myocardial ischemia/hypoxia; myocardium ischemia; neoplasm/cancer; nuclear factor kappa beta; nuclear factor of activated T-cells, cytoplasmic; nuclear factors of activated T-cells; pathway; programs; pulmonary; research study; siRNA; social role; therapy development; tissue repair; transcription factor; transcription factor NF-AT; transgenic; treatment development; tumor growth; vascular; vascular inflammation; white blood cell; white blood corpuscle","VEGF, Transcriptional Networks and Vascular Inflammation",,82927,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,4,382500,
7765554,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL083155-04,,NHLBI:390000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,GENETICS,04,044387793,US,NC,27705,DUKE UNIVERSITY,"MARCHUK, DOUGLAS A;",1922527;,5R01HL083155,02/20/2007,01/31/2011,"Ablation; Accounting; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Biological; Calsequestrin; Candidate Disease Gene; Candidate Gene; Cardiac; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic Obstructive; Causality; Cause of Death; Chromosome Mapping; Clinical; Complex; Congenic Strain; Congestive Cardiomyopathy; Data; Development; Dilated Cardiomyopathy; Disease; Disease Progression; Disorder; Dysfunction; Etiology; Evaluation; Forecast of outcome; Functional disorder; Future; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetics, Gene Mapping; Genome, Human; Goals; Haplotypes; Heart; Heart failure; Human; Human Genome; Human, General; Hypertrophic Cardiomyopathy; Inbred Strain; Investigation; Investigators; Knock-out; Knockout; Knowledge; Light; Linkage Mapping; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Metabolic; Mice; Mice, Transgenic; Modeling; Molecular; Murine; Mus; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pathway interactions; Patients; Pattern; Phenotype; Photoradiation; Physiopathology; Population; Pressure; Pressure- physical agent; Primary idiopathic dilated cardiomyopathy; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; QTL; Quantitative Trait Loci; Recombinants; Refractory; Research Personnel; Researchers; Risk; Role; Series; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Syndrome; Testing; Therapeutic Intervention; Transgenes; Transgenic Mice; Transgenic Organisms; Translating; Translatings; Validation; Variant; Variation; Work; cardiac failure; clinical relevance; clinically relevant; cohort; congenic; constriction; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; gain of function; gene product; genetic mapping; genetic risk factor; heart function; hypertrophic myocardiopathy; idiopathic dilated cardiomyopathy; idiopathic dilative cardiomyopathy; inherited factor; intervention therapy; language translation; loss of function; meetings; model organism; mouse model; myocardium disorder; novel; outcome forecast; pathophysiology; pathway; pressure; programs; social role; surgery; transgenic",Identification of genetics modifiers of heart diease,,83155,GHD,Genetics of Health and Disease Study Section,,4,390000,
7763912,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL083385-03,,NHLBI:390000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"KONTOS, CHRISTOPHER D;",1906589;,5R01HL083385,02/15/2008,01/31/2012,"21+ years old; Adenoviridae; Adenoviruses; Adult; Apoptosis; Apoptosis Pathway; Assay; BZS; Bioassay; Biologic Assays; Biological Assay; Biology; Biosynthetic Proteins; Blood Vessels; Blood capillaries; Blotting, Western; Cancers; Capillaries; Capillary; Capillary, Unspecified; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Cycle Arrest; Cell Death, Programmed; Cell Signaling; Cell membrane; Cells; Cellular Expansion; Cellular Growth; Cellular Regulation; Closure by Ligation; Co-Immunoprecipitations; Cytoplasmic Membrane; Data; Development; Diabetes Mellitus; Disease; Disorder; EC 2.7; EP300; EP300 gene; Electromagnetic, Laser; Endothelial Cells; Endothelium; Enzymes; Extremities; Femoral Artery; GFAC; Gene Expression; Gene Inactivation; Gene Silencing; Gene Transcription; Generalized Growth; Genes, Reporter; Genes, p53; Genetic Transcription; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Hindlimb; Human, Adult; Hypoxia; Hypoxia Inducible Factor; Hypoxic; Image; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Immunologic, Luciferase; In Vitro; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Ischemia; Kinases; Lasers; Lead; Ligation; Light; Limb structure; Limbs; Lipids; Luciferases; MHAM; MMAC1; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mediating; Mice; Modeling; Murine; Mus; Non-Trunk; Nuclear; Organ System, Cardiovascular; Oxygen Deficiency; P53; PTEN; PTEN gene; PTEN1; PTK Receptors; Pathway interactions; Pb element; Perfusion; Phosphatase and Tensin Homolog; Phosphatases; Phosphatides; Phosphatidyl Inositol; Phosphatidylinositols; Phosphohydrolases; Phosphoinositides; Phospholipids; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Photoradiation; Plasma Membrane; Position; Positioning Attribute; Process; Proteins; PtdIns; RNA Expression; RTK; Radiation, Laser; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Reporter Genes; Response Elements; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure of femoral artery; System; System, LOINC Axis 4; TP53; TP53 gene; TRP53; Tail; Testing; Tet; Tetanus Helper Peptide; Tissue Growth; Transcription; Transcription, Genetic; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Tumor Angiogenesis; Tumor Cell; Tumor Protein p53 Gene; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular, Heart; Vegf; Western Blotting; Western Blottings; Western Immunoblotting; Yeasts; adult human (21+); angiogenesis; biological signal transduction; blood vessel disorder; capillary; cell growth; cell growth regulation; cell type; circulatory system; congenic; density; diabetes; disease/disorder; femoral artery; gene product; heavy metal Pb; heavy metal lead; hypoxia inducible factor 1; imaging; in vivo; malignancy; migration; mutant; neoplasm/cancer; neoplastic cell; new approaches; new growth; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; p300; pathway; plasmalemma; protein blotting; response; social role; subcutaneous; tumor; tumor growth; vascular",The Role of PTEN in Endothelial Biology,,83385,VCMB,Vascular Cell and Molecular Biology Study Section,,3,390000,
7800964,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL084086-04,,NHLBI:344532;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,PEDIATRICS,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"DIPAOLA, JORGE A;",6379645;,5R01HL084086,02/01/2007,01/31/2012,"ABH Blood Group; ABO blood group system; ABO blood groups; ABO(H) blood groups; Affect; Alleles; Allelomorphs; Amish; Angiohemophilia; Angiohemophilias; Biochemical; Biological; Bleeding; Canada; Candidate Disease Gene; Candidate Gene; Chromosome Mapping; Collaborations; Collection; DNA Alteration; DNA Sequence; DNA mutation; Diagnosis; Disease; Disorder; Europe; Exhibits; Family; GWAS; Gene Alteration; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Determinism; Genetic defect; Genetic mutation; Genetics, Gene Mapping; Genetics, Human; Genome Scan; Goals; H Blood Group; H Blood Group System; Hemophilia, Vascular; Hemorrhage; Hereditary; Human; Human Genetics; Human, General; Indiana; Individual; Inherited; Iowa; Linkage Analysis; Linkage Disequilibrium; Linkage Disequilibriums; Linkage Mapping; Lod Score; Man (Taxonomy); Man, Modern; Maps; Mutation; Nuclear Family; Parents; Patients; Pedigree; Penetrance; Phenotype; Play; Racial Segregation; Recruitment Activity; Research Resources; Resources; Rest; Ristocetin Cofactor; Ristocetin-Willebrand Factor; Role; Sequence Alteration; Severities; Testing; Thrombosis; Triad; Triad Acrylic Resin; Triad resin; Variant; Variation; Von willebrand factor, deficiency of; Willebrand disease; Willebrand disease, acquired; base; blood loss; clinical phenotype; disease/disorder; family based linkage study; gene discovery; genetic determinant; genetic linkage analyses; genetic linkage analysis; genetic mapping; genetic pedigree; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide linkage; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; insight; linkage analyses; member; patient population; pedigree structure; recruit; sample collection; segregation; social role; specimen collection; vWF; von Willebrand Disease; von Willebrand Factor; von Willebrand Protein; whole genome association studies; whole genome association study",Genetic Modifiers of von Willebrand Disease,,84086,ZRG1,Special Emphasis Panel,,4,344532,
7765492,R01,HL,5,,03/01/2010,02/28/2011,PA-07-070,5R01HL084159-03,,NHLBI:330750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MOBILE,UNITED STATES,PHYSIOLOGY,01,172750234,US,AL,366880002,UNIVERSITY OF SOUTH ALABAMA,"WEBER, DAVID S;",2085745;,5R01HL084159,03/07/2008,02/28/2013,"Actins; Active Oxygen; Address; Adenoviral Vector; Adenovirus Vector; Adhesion Plaques; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biochemical; Blood Pressure, High; Blood Vessels; CYBA protein, human; Caveolae; Caveolas; Cell Communication and Signaling; Cell Culture System; Cell Locomotion; Cell Migration; Cell Migration Assay; Cell Movement; Cell Signaling; Cell-Matrix Adherens Junctions; Cells; Cellular Matrix; Cellular Migration; Chemotaxis; Confocal Microscopy; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Dephosphorylation; Disease; Disorder; Event; Focal Adhesions; Focal Contacts; G Actin; Generations; Globular Actin; Hypertension; In Vitro; Injury; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Leiomyocyte; Life; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Transgenic; Microscopy, Confocal; Migration Assay; Modeling; Molecular; Mortality; Mortality Vital Statistics; Motility; Motility, Cellular; Movement; Murine; Mus; Myocytes, Smooth Muscle; NADPH oxidase-light chain; Oxidases; Oxidative Stress; Oxygen Radicals; Pathology; Patients; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Pro-Oxidants; Process; Production; Protein Dephosphorylation; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Proteins; RNA, Small Interfering; Reactive Oxygen Species; Regulation; Reporting; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Stimulus; Stress Fibers; Structure; Testing; Time; Transgenic Mice; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; adeno vector; adenovector; atheromatosis; atherosclerotic vascular disease; biological signal transduction; body movement; cell motility; chronic granulomatous disease protein 22K; cofilin; cytochrome b-245, alpha polypeptide, human; defined contribution; depolymerization; design; designing; disease/disorder; gene product; human CYBA protein; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; interventional strategy; intracellular skeleton; migration; monomer; novel; overexpression; p21 activated kinase; p22-phox; p22phox; phosphoinositide-dependent kinase 1; protein activation; repair; repaired; response; restenosis; siRNA; social role; therapeutic target; upstream kinase; vascular; vascular smooth muscle cell migration",Reactive Oxygen Species Regulation of Vascular Smooth Muscle Cell Migration,,84159,VCMB,Vascular Cell and Molecular Biology Study Section,,3,330750,
7760574,R01,HL,5,,02/01/2010,01/31/2011,PA-04-038,5R01HL084172-04,,NHLBI:292000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MEMPHIS,UNITED STATES,OTHER BASIC SCIENCES,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"FITZPATRICK, ELIZABETH ANN;",1942933;,5R01HL084172,02/01/2007,01/31/2011,"ATGN; Alveolitis; Animal Model; Animal Models and Related Studies; Antigens; Aspiration, Respiratory; Automobile Driving; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Breathing; Cells; Cytokines, Chemotactic; Detection; Development; Diagnostic; Disease; Disorder; Drivings, Automobile; Educational workshop; Environment; Exposure to; Extrinsic allergic alveolitis; Fibrosis; Goals; Granuloma; Granulomatous Lesion; Heterophil Granulocyte; Homologous Chemotactic Cytokines; IFN; ILD; Immune; Immune response; Inhalation; Inhaling; Inspiration, Respiratory; Intercrines; Interferons; Interstitial Lung Diseases; Laboratories; Lead; Lung; Lung Diseases, Interstitial; Mammals, Mice; Marrow Neutrophil; Mediating; Mice; Molecular; Morbidity; Morbidity - disease rate; Murine; Mus; NIH; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institutes of Health (U.S.); Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pathogenesis; Patients; Pattern recognition receptor; Pb element; Play; Pneumonitis, Hypersensitivity; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Production; Rare Diseases; Rare Disorder; Recruitment Activity; Respiratory System, Lung; Role; SIS cytokines; Saccharopolyspora; Shapes; Source; Staging; Symptoms; T-Cells; T-Lymphocyte; TIL4; TLR2; TLR2 receptor; Testing; Th-1 Cell; Th1 Cells; Thymus-Dependent Lymphocytes; Toll-Like Receptor 2; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; Type 1 Helper Cell; United States National Institutes of Health; Workshop; allergic pneumonitis; chemoattractant cytokine; chemokine; cytokine; disease/disorder; driving; genetic risk factor; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; improved; inherited factor; insight; inspiration; intervention development; model organism; neutrophil; pulmonary; recruit; response; social role; therapy development; thymus derived lymphocyte; treatment development",The Role of Neutrophils in Hypersensitivity Pneumonitis,,84172,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,4,292000,
7760582,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL084201-04,,NHLBI:261625;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MINNEAPOLIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"ARNDT, PATRICK G;",6628659;,5R01HL084201,02/09/2007,01/31/2012,"3-10C; AMCF-I; Acute; Adaptor Protein; Adaptor Signaling Protein; Adherence; Adherence (attribute); Adhesions; Antibodies, Blocking; Area; Binding; Binding (Molecular Function); Blocking Antibodies; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood monocyte; C-X-C Chemokine Receptor Type 4; CD184 Antigen; CDw128b; CDw128b Antigens; CMKAR2; CSBP1; CSBP2; CSPB1; CXC Chemokine Receptor 2; CXC-R4; CXCL8; CXCR-4; CXCR2; CXCR2 Protein; CXCR4; CXCR4 Receptors; CXCR4 gene; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Adhesion; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell Surface Proteins; Cell surface; Cell-Extracellular Matrix; CellLine; Cells; Cellular Adhesion; Chemicals; Chemokine (C-X-C Motif) Receptor 4; Chemokine (C-X-C) Receptor 2; Chemokine, CXC Motif, Receptor 4; Cytokines, Chemotactic; D2S201E; Dependence; Discs Large (Drosophila) Homolog 4; Discs Large Homolog 4; EC 2.7.2-; ECM; EXIP; Exposure to; Extracellular Matrix; Extracellular Signal-Regulated Kinases; FB22; Family; Fusin; GCP-1; GCP1; GRO/MGSA Receptor; HM89; HSY3RR; HeLa; Hela Cells; Heparan Sulfate; Heparin Binding; Heparin Eliminase; Heparin Lyase; Heparinase; Heparinase I; Heparitin Sulfate; Heterophil Granulocyte; High Affinity Interleukin 8 Receptor Type B; Homologous Chemotactic Cytokines; Human; Human, General; IL-8; IL-8RB; IL-8Rbeta; IL8; IL8 Receptor Type 2; IL8 gene; IL8R2; IL8RB; IL8RB gene; INFLM; Inflammation; Inflammatory; Inflammatory Response; Intercrines; Interleukin 8 Receptor Beta; Interleukin 8 Receptor Type 2; Interleukin-8 Receptor Type B; Interleukin-8 Receptors B; Interleukin-8B Receptor; Intracellular Communication and Signaling; Investigators; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; K60; LAP3; LCR1; LECT; LESTR; LPS-Associated Protein 3; LUCT; LYNAP; Lead; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Ligands; Lipopolysaccharide-Associated Protein 3; Lung; Lung Inflammation; MAP Kinase 8; MAP kinase; MAPK; MAPK14; MAPK14 gene; MAPK8 Mitogen-Activated Protein Kinase; MDNCF; MONAP; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow monocyte; Mediating; Membrane Proteins; Membrane-Associated Proteins; Methods and Techniques; Methods, Other; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Modeling; Molecular Interaction; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Murine; Mus; Mxi2; NAF; NPY3R; NPYR; NPYRL; NPYY3R; Neuropeptide Y Receptor Y3; Neutralase; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; PKC; PKC(alpha); PKCA; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PRKCA; PRKM14; PRKM15; PSD-95; PTPA; Pathway interactions; Pb element; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphotyrosyl Phosphatase Activator; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Postsynaptic Density-95; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Kinase C; Protein Kinase C Alpha; Protein Kinase Calpha; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Proteins, Cell Surface; Proteoglycan; RNA, Small Interfering; Receptor Protein; Receptor, LESTR; Receptors, CXCR2; Regulation; Research Personnel; Researchers; Respiratory System, Lung; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SAPK2A; SCYB8; SDF-1 Receptor; SDF1/PBSF Receptor CXCR4; SIS cytokines; Scheme; Seven-Transmembrane-Segment Receptor, Spleen; Side; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A2; Small Interfering RNA; Staging; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Stromal Cell-Derived Factor 1 Receptor; Surface Proteins; TSG-1; Techniques; Up-Regulation; Up-Regulation (Physiology); Upregulation; b-ENAP; biological signal transduction; c jun; c-jun Amino-Terminal Kinase; c-jun Gene; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; chemoattractant cytokine; chemokine; chemokine receptor; cultured cell line; gene product; heavy metal Pb; heavy metal lead; improved; inhibitor; inhibitor/antagonist; insight; jun-NH2-Terminal Kinase; monocyte; neutrophil; novel; p38; p38 MAPK Gene; p38Alpha; pathway; presynaptic density protein 95; programs; pulmonary; receptor; siRNA; social role; stress-activated protein kinase 1; syndecan; syndecan-4; zonula occludens-1 protein",The role of syndecan-4 in the regulation of JNK activation in human neutrophils,,84201,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,4,261625,
7760666,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL084387-04,,NHLBI:371250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,PHYSIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"ANTALIS, TONI M.;",7044506;,5R01HL084387,02/10/2007,01/31/2011,"Adhesions; Anchors, Glycosylphosphatidylinositol; Angiogenesis, Pathologic; Angiogenesis, Pathological; Animal Model; Animal Models and Related Studies; Architecture; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Bizzozero's corpuscle/cell; Blood; Blood Clotting; Blood Coagulation Factor II; Blood Platelets; Blood Vessels; Blood capillaries; Blood coagulation; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Components; Cell Migration Assay; Cell Signaling; Cell Structure; Cell surface; Cells; Cellular Structures; Clotting; Coagulation; Coagulation Factor II; Coagulation Factor II Receptor; Coagulation Process; Coupled; Data; Deetjeen's body; Differentiation Reversal Factor; Disease; Disorder; Endothelial Cells; Engineering / Architecture; Esteroproteases; F2R; Factor II; G-Proteins; GPI Membrane Anchors; GTP-Binding Proteins; GTP-Regulatory Proteins; Glycoinositol Phospholipid Membrane Anchor; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Hayem's elementary corpuscle; Immune; In Vitro; Individual; Inflammatory Response; Injury; Intracellular Communication and Signaling; Knockout Mice; Laboratories; Link; Mammals, Mice; Marrow platelet; Mediating; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Migration Assay; Molecular; Morphogenesis; Morphology; Murine; Mus; Neovascularization, Pathological; Null Mouse; PAR-1 Receptor; PAR1 Receptor; PRSS21 gene product; Participant; Pathologic Neovascularization; Pathology; Peptidases; Peptide Hydrolases; Permeability; Physiologic; Physiological; Platelets; Protease-Activated Receptor 1; Proteases; Protein Cleavage; Proteinase-Activated Receptor 1; Proteinases; Proteolysis; Proteolytic Enzymes; Proteomics; Prothrombin; Receptor, PAR-1; Regulation; Reporter; Rest; Reticuloendothelial System, Blood; Reticuloendothelial System, Platelets; Role; Serine Endopeptidases; Serine Protease; Serine Protein Hydrolases; Serine Proteinases; Signal Transduction; Signal Transduction Systems; Signaling; Testing; Therapeutic Intervention; Thrombase; Thrombin; Thrombin Receptor; Thrombocytes; Tumor Angiogenesis; VEGFs; Vascular Diseases; Vascular Disorder; Vascular Endothelial Growth Factors; Vascular Permeabilities; Vascular remodeling; Vegf; angiogenesis; base; biological signal transduction; blood vessel disorder; capillary; capillary bed; disease/disorder; fibrinogenase; in vitro Assay; in vivo; intervention therapy; matrigel; membrane structure; migration; model organism; mouse model; novel therapeutic intervention; prothrombin activator; response; social role; testisin; thrombocyte/platelet; tumor; tumor growth; vascular; vascular bed",Vascular Remodeling by Membrane Serine Proteases,,84387,ZRG1,Special Emphasis Panel,,4,371250,
7762210,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL084487-04,,NHLBI:380000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MERCED,UNITED STATES,NONE,18,113645084,US,CA,95343,"UNIVERSITY OF CALIFORNIA, MERCED","ESCOBAR, ARIEL L;",6982552;,5R01HL084487,02/01/2007,01/31/2012,"Action Potentials; Address; Animal Model; Animal Models and Related Studies; Binding; Binding (Molecular Function); Binding Proteins; Biological Models; Buffers; Calsequestrin; Cardiac; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Chronotropism, Cardiac; Chronotropisms, Cardiac; Data; Death, Sudden, Cardiac; Defect; Diffusion; Dysfunction; ECG; EKG; Electrocardiogram; Electrocardiography; Endocardium; Epicardium; Experimental Models; Experimental Models, Other; Fluorescence Microscopy; Functional disorder; Heart; Heart Rate; Immune; Intermediary Metabolism; Intracellular Communication and Signaling; Intraventricular Pressure; Investigators; Lead; Left; Ligand Binding Protein; Link; METBL; Mammals, Mice; Maps; Measurement; Measures; Membrane Potentials; Metabolic; Metabolic Processes; Metabolic stress; Metabolism; Methods; Mice; Mice, Transgenic; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Model System; Modeling; Models, Biologic; Models, Experimental; Models, Theoretic; Molecular; Molecular Interaction; Monitor; Murine; Mus; Organ; Pathology; Pb element; Phase; Physiologic intraventricular pressure; Physiologic pulse; Physiopathology; Predisposition; Process; Programs (PT); Programs [Publication Type]; Pulse; Pump; Reaction; Relaxation; Research Personnel; Researchers; Residual; Residual state; Resolution; Resting Potentials; Sarcoplasmic Reticulum; Signal Transduction; Signal Transduction Systems; Signaling; Site; Surface; Susceptibility; Tachycardia; Testing; Theoretical model; Time; Transgenic Animals; Transgenic Mice; Transmembrane Potentials; Ventricular; Ventricular Pressure; Work; biological signal transduction; cultured cell line; heavy metal Pb; heavy metal lead; model organism; novel; pathophysiology; programs; reuptake; uptake",Subcellular Origin of T-wave Alternans in the Beating Mouse Heart,,84487,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,4,380000,
7763875,R01,HL,5,,02/01/2010,01/31/2011,PAR-03-106,5R01HL084502-04,,NHLBI:393750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BARBIERI, RICCARDO ;",8372435;,5R01HL084502,02/01/2007,01/31/2012,"Address; Agreement; Algorithms; Anesthesia; Anesthesia procedures; Area; Autonomic nervous system; Biological; Brain; Cardiac Failure Congestive; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Chronotropism, Cardiac; Chronotropisms, Cardiac; Circadian Rhythms; Clinical Research; Clinical Study; Computer Programs; Computer software; Congestive Heart Failure; Data; Data Set; Dataset; Detection; Diagnosis; Diurnal Rhythm; Dysfunction; ECG; EKG; Electrocardiogram; Electrocardiography; Encephalon; Encephalons; Event; Fetus; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Functional disorder; Generations; HOSP; Health; Heart; Heart Decompensation; Heart Failure, Congestive; Heart Rate; Hospitals; Human; Human, General; Intensive Care Units; Investigators; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Inspection; Meditation; Methods; Modeling; Monitor; Nervous System, Brain; Nyctohemeral Rhythm; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Patients; Physical Examination; Physiologic; Physiological; Physiology; Physiopathology; Process; Regulation; Research; Research Personnel; Researchers; Series; Simulate; Sleep; Software; Statistical Methods; Structure; Surgical; Surgical Interventions; Surgical Procedure; Testing; Time; Treatment Efficacy; Twenty-Four Hour Rhythm; Vascular, Heart; Woman; base; cardiovascular disorder; circadian; circadian process; circulatory system; clinical practice; computer program/software; daily biorhythm; design; designing; diurnal variation; experiment; experimental research; experimental study; fMRI; heart rate variability; mindfulness; pathophysiology; research study; surgery; theories; therapeutic efficacy; therapeutically effective; web site",Point Process Models of Human Heart Beat Interval Dynamics,,84502,MABS,Modeling and Analysis of Biological Systems Study Section,,4,393750,
7762719,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL084529-03,,NHLBI:374051;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,INDIANAPOLIS,UNITED STATES,BIOMEDICAL ENGINEERING,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"KASSAB, GHASSAN S;",6413643;,5R01HL084529,02/01/2008,01/31/2013,"Acute; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Affect; Age; American; Animal Welfare; Animals; Area; Bibliography; Bioavailability; Biochemical; Biologic Availability; Biological Availability; Biomedical Engineering; Blood Pressure; Blood Vessels; Blood flow; CNOS; Cardiac; Cardiac Failure Congestive; Cardiac Output; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cellular Matrix; Chronotropism, Cardiac; Chronotropisms, Cardiac; Coenzyme II; Congestive Heart Failure; Constitutive NOS; Country; Cytoskeletal System; Cytoskeleton; Data; Deterioration; Diagnosis; Disease; Disorder; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; EFRAC; ENOS; Ecological impact; Ejection Fraction; Endogenous Nitrate Vasodilator; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Engineering; Engineerings; Environment; Environmental Impact; Enzymes; Equilibrium; Equipment; Erythrocuprein; Ethics Committees, Research; Functional disorder; Generations; Guanylyl Cyclase-Activating Factor Synthase; Heart; Heart Decompensation; Heart Failure, Congestive; Heart Rate; Heart failure; Hemocuprein; IACUC; IRBs; Impact, Environmental; Incidence; Institutional Animal Care and Use Committee; Institutional Review Boards; International; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Laboratories; Lead; Leiomyocyte; Manuscripts; Measurement; Mediating; Methods; Microcirculation; Modeling; Molecular; Mononitrogen Monoxide; Myocytes, Smooth Muscle; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NADPH-Diaphorase; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; National Heart, Lung, and Blood Institute; Nature; Nicotinamide-Adenine Dinucleotide Phosphate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; Oxidases; Oxidative Stress; Oxides; Paper; Patients; Pb element; Peripheral; Peripheral Resistance; Physiologic Availability; Physiology; Physiopathology; Population; Pressure; Pressure- physical agent; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; PubMed; Publications; Publishing; Relaxation, Vascular Endothelium-Dependent; Research; Research Ethics Committees; Research Resources; Resistance, Total Peripheral; Resources; Role; SOD; Scientific Publication; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Source; Stimulus; Stroke Volume; Superoxide Anion; Superoxide Dismutase; Superoxide Radical; Superoxide[{..}]superoxide oxidoreductase; Superoxides; System; System, LOINC Axis 4; Testing; Triphosphopyridine Nucleotide; Uncertainty; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Endothelial Cell; Vascular Endothelium-Dependent Relaxation; Vascular Resistance, Systemic; Vascular System; Vascular, Heart; Vertebrate Animals; Vertebrates; Western World; Work; abstracting; awake; balance; balance function; bioavailability of drug; bioengineering; bioengineering/biomedical engineering; cardiac failure; circulatory system; cytocuprein; disease/disorder; doubt; eNOS enzyme; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; expiration; heart output; heavy metal Pb; heavy metal lead; hemodynamics; human NOS3 protein; human subject; in vivo; intracellular skeleton; novel; pathophysiology; physical state; pressure; programs; protein expression; response; shear stress; social role; stem; vascular; vertebrata",The Role of Shear Stress in Heart Failure,,84529,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,3,374051,
7765553,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL084553-04,,NHLBI:423750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"SEIDMAN, JONATHAN G;",6918616;,5R01HL084553,02/01/2007,01/31/2012,"ANF; ANH; ANP; Address; Aged 65 and Over; Asymmetric Septal Hypertrophy, Familial; Atrial Natriuretic Factor; Atriopeptins; Auriculin; Biochemical; Body Tissues; Candidate Disease Gene; Candidate Gene; Cardiac; Cardiac Remodeling, Ventricular; Cardiomyopathies; Cardiomyopathy, Hypertrophic Obstructive; Cardiomyopathy, Hypertrophic, Familial; Cell Communication and Signaling; Cell Signaling; Cells; Childhood; Clinical; Complex; DNA Alteration; DNA mutation; Data; Development; Disease; Disorder; Elderly; Elderly, over 65; Environmental Factor; Environmental Risk Factor; Expression Profiling; Expression Signature; Fibrosis; Framingham Heart Study; Galactosidase; Gene Alteration; Gene Expression; Gene Mutation; Gene Products, RNA; Gene Targeting; Gene Transcription; Genes; Genes, LacZ; Genes, Reporter; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic mutation; HTRPY; Heart; Histopathology; Homeo Boxes; Homeobox; Hop protein; Human; Human, General; Hypertrophic Cardiomyopathy; Hypertrophy; Hypertrophy, Left Ventricular; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; LV Mass; LacZ; LacZ Genes; Left Ventricles; Left Ventricular Hypertrophy; Left Ventricular Mass; Left ventricular structure; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Molecular; Molecular Fingerprinting; Molecular Genetic; Molecular Genetics; Molecular Profiling; Monitor; Murine; Mus; Muscle Cells; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardial Remodeling, Ventricular; Myocardiopathies; Myocardium; Myocytes; Myosin Heavy Chains; Natriuretic Peptides, Atrial; Participant; Pathologic; Pathway interactions; Population; Predisposing Factor; Prevalence; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA; RNA Expression; RNA, Non-Polyadenylated; Reporter Genes; Ribonucleic Acid; Role; Sampling; Sarcomeres; Sequence Alteration; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Targetings, Gene; Techniques; Technology; Tissues; Transcription; Transcription, Genetic; Variant; Variation; Ventricle Remodeling; Ventricular; Ventricular Hypertrophy, Familial; Ventricular Remodeling; advanced age; atrial natriuretic hormone; base; biological signal transduction; cardiac muscle; cardiovascular risk; cardiovascular risk factor; disease/disorder; elders; environmental risk; experiment; experimental research; experimental study; gene product; genome mutation; geriatric; heart muscle; hemodynamics; hop gene product; hopscotch protein; hypertrophic myocardiopathy; late life; later life; molecuar profile; molecular marker; molecular signature; mouse model; myocardial remodeling; myocardium disorder; myosin heavy chain; new technology; older adult; older person; pathway; pediatric; research study; response; senior citizen; social role; trait; transcription factor",Molecular Signaling in Hypertrophic Cardiomyopathy,,84553,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,4,423750,
7754125,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL084615-04,,NHLBI:363740;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MADISON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KAMP, TIMOTHY J;",1889105;,5R01HL084615,01/15/2007,12/31/2010,"2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide; 3,5,3',5'-Tetraiodothyronine; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Active Oxygen; Acute; Anaplastic; Animal Model; Animal Models and Related Studies; Antioxidants; Assay; Athymic Nude Mouse; BUdR; Benefits and Risks; Bioassay; Biologic Assays; Biological Assay; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; Cardiac; Cardiac Myocytes; Cardiac Remodeling, Ventricular; Cardiac infarction; Cardiocyte; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Respiration; Cell Survival; Cell Therapy; Cell Transplantation; Cell Transplants; Cell Viability; Cell fusion; Cell model; Cell surface; Cell/Tissue, Immunohistochemistry; Cells; Cellular Proliferation; Cellular Respiration; Cellular model; Commit; Coronary Thrombosis; Data; Diazoxide; ES cell; Echocardiogram; Echocardiography; Effects, Longterm; Electrophysiology; Electrophysiology (science); Embryo; Embryonic; Embryonic Stem Cell Transplantation; Engraftment; Environment; Exhibits; Genetic Markers; Goals; Heart; Heart myocyte; Histology; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Infarction; Injection of therapeutic agent; Injections; Institutes; Investigators; Ischemia; Ischemic Preconditioning; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; LV remodeling; Label; Left Ventricular Remodeling; Levothyroxine; Long-Term Effects; Longitudinal Studies; Mammals, Mice; Mesoderm; Methods and Techniques; Methods, Other; Mice; Mice, Athymic; Mice, Nude; Mitochondria; Modeling; Mother Cells; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle Tissue; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Remodeling, Ventricular; Myocardium; Myocytes; Myocytes, Cardiac; Myosin Light Chains; Natural regeneration; Neurophysiology / Electrophysiology; Nude Mice; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Oncogenesis; Outcome; Oxidative Stress; Oxygen Radicals; Pathology; Patients; Pattern; Phenotype; Population; Preconditionings, Ischemic; Pro-Oxidants; Progenitor Cells; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RT-PCR; RTPCR; Reactive Oxygen Species; Regeneration; Relative; Relative (related person); Reliance; Reperfusion Therapy; Reporter; Research; Research Personnel; Researchers; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Risk; Role; Safety; Scanning; Stem Cell Transplantation, Embryonic; Stem cells; Stress; Structure; T4 Thyroid Hormone; Techniques; Technology; Testing; Therapeutic Levothyroxine; Therapy, Cell; Thymosin; Thyroxine; Time; Transplantation; Transplants, Cell; Transthoracic Echocardiography; Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-; Undifferentiated; Uridine, 5-bromo-2'-deoxy-; Ventricle Remodeling; Ventricle Remodelings, Left; Ventricular; Ventricular Remodeling; aerobic metabolism; aerobic respiration; anti-oxidant; cardiac infarct; cardiac muscle; cardiomyocyte; cell preparation; cell type; cell-based therapy; clinical applicability; clinical application; coronary attack; coronary infarct; coronary infarction; electrical property; embryonic stem cell; experiment; experimental research; experimental study; function improvement; functional improvement; functional loss; gene product; hESC; heart attack; heart infarct; heart infarction; heart muscle; heart sonography; human ES cell; human ESC; human embryonic stem cell; improved; improved functioning; in vitro Model; infarct; injured; insight; long-term study; minimal risk; mitochondrial; model organism; myocardial remodeling; novel therapeutic intervention; oxidative metabolism; paracrine; patient population; preclinical study; preconditioning; progenitor; protein expression; regenerate; repair; repaired; reperfusion; research study; resistant; reverse transcriptase PCR; social role; sound measurement; stem cell of embryonic origin; stem cell population; thyroxin; transplant; tumor; tumorigenesis; tumorigenic",Embryonic Stem Cell-based Therapies for Myocardial Infarction,,84615,MIM,Myocardial Ischemia and Metabolism Study Section,,4,363740,
7760166,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL085061-04,,NHLBI:425930;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,OMAHA,UNITED STATES,PHARMACOLOGY,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"BIDASEE, KESHORE R;",1874256;,5R01HL085061,02/01/2007,01/31/2011,"0-11 years old; 1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 21+ years old; 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-; ATP phosphohydrolase (Ca(2+)-transporting); Acetylformaldehyde; Address; Adenosine Diphosphate Ribose, Cyclic; Adenosine Triphosphatase, Calcium; Adenosine Triphosphate, Magnesium Salt; Adhesions; Adolescent; Adolescent Youth; Adult; Amines; Amino Acids; Animal Model; Animal Models and Related Studies; Animals; Arginine; Arginine, L-Isomer; Arrhythmia; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Blood Plasma; Blood Vessels; Blotting, Western; Body Tissues; Ca Release Channel-Ryanodine Receptor; Ca(2+)-Transporting ATPase; Ca++ element; Ca2+ ATPase; Ca2+ transporting ATPase; Caffeine; Calcium; Calcium ATPase; Calcium Adenosinetriphosphatase; Calcium Pump; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium-Ryanodine Receptor Complex; Calmodulin; Cardiac; Cardiac Arrhythmia; Caring; Causality; Cell Culture Techniques; Cells; Charge; Child; Child Youth; Children (0-21); Coagulation Factor IV; Common Rat Strains; Complex; Confocal Microscopy; Contracting Opportunities; Contracts; Coupling; Cyclic ADP-Ribose; Cyclic ADPribose; Data; Death, Sudden, Cardiac; Defect; Depressed mood; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type I; Diabetes Mellitus, Type II; Dissociation; Dysfunction; Echocardiogram; Echocardiography; Enzymes; Epidemic; Etiology; Exercise; Exercise, Physical; Exhibits; FK506-binding protein 1B; FKBP12.6; Factor IV; Frequencies (time pattern); Frequency; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Gln; Glutamine; Heart; Heart Arrhythmias; Heart failure; Histidine; Histidine, L-isomer; Human, Adult; Human, Child; IDD; IDDM; Impairment; In Vitro; Incubated; Individual; Insulin-Dependent Diabetes Mellitus; Intraventricular Pressure; Investigators; Knowledge; L-Arginine; L-Glutamine; L-Histidine; L-Lysine; Laboratories; Left; Life; Ligands; Lysine; M-Mode Echocardiography; MODY; Magnesium Adenosine Triphosphate; Mammals, Rats; Mass Spectrum; Mass Spectrum Analysis; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Mediating; Membrane; Metabolic syndrome; Methylglyoxal; MgATP; Microscopy, Confocal; Modeling; Molecular; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle Cells; Muscle Cells, Mature; Mutagenesis, Site-Directed; Mutation; Myocardial; Myocardial depression; Myocardial dysfunction; Myocytes; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Oxidants; Oxidizing Agents; Patients; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Photometry/Spectrum Analysis, Mass; Physiologic intraventricular pressure; Physiopathology; Plasma; Probability; Production; Programs (PT); Programs [Publication Type]; Propanal, 2-oxo-; Protein Phosphorylation; Proteins; Pyridoxamine; Pyruvaldehyde; Pyruvic Aldehyde; Q. Levoglutamide; QOL; Quality of life; Rat; Rat model of diabetes; Rattus; Receptors, Ryanodine; Recombinants; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Role; RyR2; Ryanodine; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Ryanodol, 3-(1H-pyrrole-2-carboxylate); SERCA2a; STZ; Sarcoplasmic Reticulum; Semicarbazides; Serum, Plasma; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Streptozocin; Streptozotocin; Stress; Syndrome; T1 diabetes; T1D; T1DM; T2D; T2DM; TXT; Targeted DNA Modification; Targeted Modification; Testing; Text; Therapeutic; Time; Tissues; Training; Transthoracic Echocardiography; Type 1 diabetes; Type 2 diabetes; Type II diabetes; Ventricular; Ventricular Pressure; Western Blotting; Western Blottings; Western Immunoblotting; Work; Zanosar; adduct; adult human (21+); adult onset diabetes; amine oxidase; aminoacid; cADP-Ribose; cADPR; calcium transporting ATPase; calstabin 2 protein, human; cardiac failure; children; depressed; design; designing; diabetes; diabetic; diabetic cardiomyopathy; diabetic cardiopathy; diabetic cardiopathy disease; diabetic cardiopathy disorder; diabetic cardiovascular disease; diabetic cardiovascular disorder; diabetic patient; diabetic rat; diabetic rat model; disease causation; disease etiology; disease/disorder etiology; disorder etiology; economic cost; electron acceptor; gene product; genome mutation; heart sonography; hemodynamics; improved; in vivo; insight; insulin dependent diabetes; juvenile; juvenile diabetes; juvenile diabetes mellitus; juvenile human; ketosis prone diabetes; ketosis resistant diabetes; maturity onset diabetes; membrane structure; model organism; mutant; new therapeutics; next generation therapeutics; novel therapeutics; pathophysiology; programs; protein blotting; prototype; response; sadness; social role; sound measurement; stem; tacrolimus binding protein 1B; type I and type II diabetes; type I diabetes; vascular; youngster",Role of Ryanodine Receptors in Diabetic Cadiomyopathy,,85061,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,4,425930,
7758765,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL085311-03,,NHLBI:304000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"HARPER, RICHART W;",7599376;,5R01HL085311,02/01/2008,01/31/2013,"Acids; Acute; Address; Animal Welfare; Anti-Viral Response; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Apical; Asthma; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bibliography; Binetrakin; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Bronchial Asthma; Center for Translational Science Activities; Clinical; Consult; Country; Critiques; Ecological impact; Environment; Environmental Impact; Epithelial Cells; Epithelium; Equipment; Ethics Committees, Research; Event; Future; Generations; Genes; H2O2; Head; Health Sciences; Host Defense; Hour; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; IACUC; IL-13; IL-4; IL13; IL4; IL4 Protein; IRBs; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; International; Knowledge; Literature; Lung; Lymphocyte Stimulatory Factor 1; MCGF-2; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Mediating; Modeling; Patients; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Proteins; Public Health; Pulmonary Body System; Pulmonary Organ System; Reactive Nitrogen Species; Research; Research Ethics Committees; Research Resources; Resources; Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Rhinovirus; Services; Signal Pathway; System; System, LOINC Axis 4; T-Cell Growth Factor 2; Testing; Time; Tracts, Respiratory; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Viral; Viral Diseases; Virus Diseases; W 7; W7 (Calmodulin Antagonist); abstracting; airway epithelium; asthmatic patient; cytokine; expiration; gene product; human subject; novel; pathogen; professor; programs; public health medicine (field); pulmonary; respiratory tract; statistics/biometry; vertebrata; viral infection; virus infection",Duox2 Modulation of Viral Infection in Airway Epithelium,,85311,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,3,304000,
7761680,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL085439-03,,NHLBI:397500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,VALHALLA,UNITED STATES,PHARMACOLOGY,18,041907486,US,NY,10595,NEW YORK MEDICAL COLLEGE,"FERRERI, NICHOLAS R;",1899930;,5R01HL085439,02/01/2008,01/31/2012,"Address; Affect; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Antimorphic mutation; Area; Assay; Attenuated; BP control; Back; Bioassay; Biologic Assays; Biological; Biological Assay; Blood Pressure; Blood Pressure, High; COX-2; COX2; Cachectin; Cachectin-Tumor Necrosis Factor; Cardiovascular; Cardiovascular Body System; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cells; Confusion; Confusional State; Dinoprostone; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Dose; Electrolytes; Excretory function; Exhibits; Feedback; Genetic; Hydrogen Oxide; Hypertension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; In Vitro; Infusion; Infusion procedures; Interruption; Isoforms; Kidney Neoplasms; Laboratories; Laser Scanning Cytometry; Link; Measurement; Measures; Mediating; Mental Confusion; Minor; Modeling; Molecular; Molecular Transport; Natriuresis; Organ System, Cardiovascular; PGE2; PGE2 alpha; PGE2alpha; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Pressure; Pressure- physical agent; Production; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Protein Isoforms; Protocol; Protocols documentation; Receptor Protein; Regulation; Renal Neoplasms; Renal Tumor; Renal function; Reporter; Sodium Chloride; Sodium chloride (NaCl); TNF-alpha; Telemetries; Telemetry; Testing; Transfection; Transport Process; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor of the Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Water; basolateral membrane; blood pressure control; blood pressure homeostasis; blood pressure regulation; cardiovascular function; circulatory system; cytokine; excretion; experiment; experimental research; experimental study; extracellular; hCOX-2; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; kidney function; pressure; prevent; preventing; receptor; research study; response; salt; urinary",Regulation of Renal TNF Production and Function,,85439,HM,Hypertension and Microcirculation Study Section,,3,397500,
7763812,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL085708-03,,NHLBI:425670;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BARNETT, JOEY V;",1866889;,5R01HL085708,02/01/2008,01/31/2012,"21+ years old; Accounting; Address; Adult; Animal Welfare; Animal growth regulators, transforming growth factors; Animals; Antisera; Appearance; Assay; Basic Research; Basic Science; Beta-Glycan; Betaglycan; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood Vessels; Body Tissues; Cardiovascular Diseases; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Lineage; Cell Signaling; Cells; Cessation of life; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Vessels; Country; Data; Death; Derivation; Derivation procedure; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Ecological impact; Editorial Comment; Editorial Comment (PT); Embryo; Embryonic; Endothelial Cells; Environment; Environmental Impact; Epicardium; Epithelial; Equipment; Ethics Committees, Research; FLR; Failure (biologic function); Generations; Genes, LacZ; Hand; Human; Human, Adult; Human, General; IACUC; IRBs; Immune Sera; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigators; Laboratories; LacZ; LacZ Genes; Left; Lymphocytes, Null; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Modeling; Murine; Mus; Muscle, Cardiac; Muscle, Heart; Muscle, Involuntary; Muscle, Smooth; Myocardial; Myocardium; Nature; Null Cells; Null Lymphocytes; Pathway interactions; Principal Investigator; Programs (PT); Programs [Publication Type]; Published Comment; Receptor Protein; Regulation; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth muscle (tissue); Specificity; Stream; TGF beta type III receptor; TGFBR3; TGFR3; Testing; Therapeutic; Tissues; Transforming Growth Factor Beta Receptor III; Transforming Growth Factor Beta Receptor Type III; Transforming Growth Factors; Tumor Growth Factors; United States; Venous; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; adult human (21+); biological signal transduction; cardiac muscle; cardiovascular disorder; cell behavior; disease/disorder; experiment; experimental research; experimental study; expiration; failure; heart muscle; human subject; immortalized cell; improved; in vitro testing; in vivo; injured; insight; meetings; novel; pathway; programs; protein expression; receptor; repair; repaired; research study; social role; type III TGFbeta receptor; vascular; vascular bed; vasculogenesis; vertebrata",Type III Transforming Growth Factor beta Receptor in Coronary Vessel Development,,85708,CDD,Cardiovascular Differentiation and Development Study Section,,3,425670,
7763877,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL085727-03,,NHLBI:380000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHIAMVIMONVAT, NIPAVAN ;",6559113;,5R01HL085727,02/01/2008,01/31/2012,"Acids; Animal Welfare; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Apoptotic; Arrhythmia; Bibliography; Biochemical; Biological; Cardiac; Cardiac Arrhythmia; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Chest; Clinical; Country; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Data; Deterioration; Development; Echocardiogram; Echocardiography; Ecological impact; Endothelium; Environment; Environmental Impact; Epoxide Hydrases; Epoxide Hydratases; Epoxide hydrolase; Equipment; Ethics Committees, Research; Experimental Designs; FLR; Failure (biologic function); Figs; Figs - dietary; Gene Transcription; Generalized Growth; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Goals; Growth; Hand; Heart; Heart Arrhythmias; Heart Hypertrophy; Heart failure; Heart myocyte; Histology; Hypotensive Agent; Hypotensive Drugs; Hypotensives; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigation; Laboratories; Literature; Malignant; Malignant - descriptor; Measurement; Mediating; Medical Imaging, Positron Emission Tomography; Molecular; Muscle Cells, Cardiac; Muscle Cells, Heart; Mutation; Myocardial Infarct; Myocardial Infarction; Myocytes, Cardiac; Noise; Nuclear; P450; PET; PET Scan; PET imaging; PETSCAN; PETT; Pathologic; Pathway interactions; Patients; Physiologic; Physiological; Positron Emission Tomography Scan; Positron-Emission Tomography; Pressure; Pressure- physical agent; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Proton Magnetic Resonance Spectroscopic Imaging; RNA Expression; Rad.-PET; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Risk; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Stress; Testing; Therapeutic; Thorace; Thoracic; Thorax; Tissue Growth; Transcription; Transcription, Genetic; Transthoracic Echocardiography; Uncertainty; Vertebrate Animals; Vertebrates; abstracting; base; biological signal transduction; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiomyocyte; clinical significance; clinically significant; constriction; coronary attack; coronary infarct; coronary infarction; cytokine; doubt; experiment; experimental research; experimental study; expiration; failure; gene product; genome mutation; heart attack; heart infarct; heart infarction; heart sonography; hemodynamics; human subject; improved; in vivo; inhibitor; inhibitor/antagonist; insight; mouse model; new therapeutic target; novel; ontogeny; pathway; pressure; prevent; preventing; programs; research study; response; sound measurement; tool; ventricular hypertrophy; vertebrata",Mechanisms and Treatment of Cardiac Arrhythmias,,85727,ZRG1,Special Emphasis Panel,,3,380000,
7760163,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL085738-03,,NHLBI:328500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLESTON,UNITED STATES,PEDIATRICS,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BAATZ, JOHN E;",1868433;,5R01HL085738,02/01/2008,01/31/2012,"A549; Acute; Address; Affect; Alveolar; Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Animal Welfare; Animals; Antibodies; BP control; Bibliography; Binding; Binding (Molecular Function); Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Pressure; Blood Segmented Neutrophil; Body Tissues; CD143 Antigens; Carboxycathepsin; Cause of Death; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular injury; Co-culture; Cocultivation; Coculture; Coculture Techniques; Complex; Country; Cristobalite; Critiques; Data; Dependency; Dependency (Psychology); Development; Developmental Biology; Dipeptidyl Peptidase A; Disease; Disorder; ELISA; Ecological impact; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium-Derived Relaxing Factor; Environment; Environmental Impact; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Equipment; Erythroid; Erythroid Cells; Ethics Committees, Research; Exposure to; Fiber; Gases; Gene Chips; Gene Expression; Gene Expression Chip; Genes; Genetic; Globin; Hematology; Hemoglobin; Heterophil Granulocyte; Human; Human, General; Hypertension, Pulmonary; Hypoxia; Hypoxic; IACUC; INFLM; IRBs; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Impact, Environmental; Individual; Infant, Premature; Inflammation; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Ischemia; Isotope Labeling; Kininase A; Kininase II; L-NAME; LC/MS; Lead; Lung; Lung Alveolar Epithelia; Lung Surfactant; METBL; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Measures; Mesenchymal; Metabolic Processes; Metabolism; Mice; Molecular Interaction; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Murine; Mus; N omega-Nitro-L-arginine Methyl Ester; N(G)-Nitro-L-arginine Methyl Ester; N(G)-Nitroarginine Methyl Ester; NG-Nitro-L-Arginine Methyl Ester; NG-Nitroarginine Methyl Ester; Natural Immunity; Natural regeneration; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Ni element; Nickel; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Outcome; Oxidative Stress; Oxygen Deficiency; Paper; Pathology; Pb element; Peptides; Peptidyl-Dipeptidase A; Physiology; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Premature Infant; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Pulmonary Fibrosis; Pulmonary Hypertension; Pulmonary Surfactants; Regeneration; Reperfusion Therapy; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Respiratory System, Lung; Respiratory distress; Rodent; Rodentia; Rodentias; Role; Sand; Silica; Silicon Dioxide; Structure of alveolar epithelium; Subcellular Process; Testing; Therapeutic Agents; Time; Tissues; Tridymite; Type II Pneumocyte; Vertebrate Animals; Vertebrates; abstracting; alveolar epithelium; alveolar type II cell; blood pressure control; blood pressure homeostasis; blood pressure regulation; cell damage; cell injury; cultured cell line; disease/disorder; emotional dependency; endothelial cell derived relaxing factor; enzyme activity; experiment; experimental research; experimental study; expiration; gene product; heavy metal Pb; heavy metal lead; human subject; in vivo; in vivo Model; liquid chromatography mass spectrometry; neutrophil; nitrosative stress; novel; p-Globin; preconditioning; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; programs; protective effect; protein degradation; pulmonary; regenerate; reperfusion; research study; social role; surfactant; vertebrata",Expression and Function of Hemoglobin in Alveolar Epithelial Cells,,85738,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,3,328500,
7755041,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL086322-03,,NHLBI:413049;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOS ANGELES,UNITED STATES,,31,052277936,US,CA,900276062,CHILDREN'S HOSPITAL LOS ANGELES,"BELLUSCI, SAVERIO ;",6953994;,5R01HL086322,02/01/2008,01/31/2013,"21+ years old; Adult; Alveolar; Animal Welfare; Animals; Apert syndrome; Autocrine Systems; Autoregulation; Bibliography; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Signaling; Country; DNA Synthesis Factor; Data; Defect; Distal; ECGF; Ecological impact; Embryo; Embryonic; Endothelial Cell Growth Factor; Environment; Environmental Impact; Epithelial; Epithelium; Equipment; Ethics Committees, Research; Exhibits; FGF; FGF10; FGF10 gene; FGFR2b; Family; Feedback; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Future; GFAC; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HBGF; Health; Homeostasis; Human, Adult; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Keratinocyte Growth Factor 2 Gene; Leiomyocyte; Lobe; Lung; Mammals, Mice; Mediating; Mesenchymal; Mesenchymal Differentiation; Mesenchymas; Mesenchyme; Mice; Modeling; Murine; Mus; Myocytes, Smooth Muscle; Neonatal; Patients; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Reporting; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Respiratory System, Lung; Respiratory physiology; Role; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Study Type; Testing; Vertebrate Animals; Vertebrates; abstracting; adult human (21+); autocrine; biological signal transduction; expiration; fibroblast growth factor receptor 2b; human subject; in vivo; lung development; lung function; member; mouse model; neonatal death; prevent; preventing; progenitor; programs; pulmonary; repair; repaired; respiratory function; social role; study design; vertebrata",Growth Factors in Lung Development,,86322,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,3,413049,
7765496,R01,HL,5,,03/01/2010,02/28/2011,,5R01HL086392-05,,NHLBI:390828;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PHYSIOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"ZHOU, MING ;",6715123;,5R01HL086392,03/15/2006,02/28/2011,"Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Architecture; Binding; Binding (Molecular Function); Catalysis; Cell membrane; Cells; Chemotherapy-Hormones/Steroids; Coenzyme II; Communication; Complex; Coupled; Coupling; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasmic Membrane; Dehydrogenases; Diffuse; Endocrine Gland Secretion; Engineering / Architecture; Family; Goals; Heart; Hormones; Hypoxia; Hypoxic; Integral Membrane Protein; Intrinsic Membrane Protein; Investigators; Ion Channels, Potassium; K channel; K+ element; Membrane; Membrane Potentials; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nicotinamide-Adenine Dinucleotide Phosphate; Organism-Level Process; Organismal Process; Oxidation-Reduction; Oxidative Stress; Oxidoreductase; Oxygen Deficiency; Physiologic Processes; Physiological Processes; Physiology; Plasma Membrane; Potassium Channel; Programs (PT); Programs [Publication Type]; Proteins; Reagent; Redox; Reductases; Research Personnel; Researchers; Resolution; Rest; Resting Potentials; Side; Single Crystal Diffraction; Structure; Testing; Therapeutic; Therapeutic Hormone; Transmembrane Potentials; Transmembrane Protein; Triphosphopyridine Nucleotide; V (voltage); X Ray Crystallographies; X-Ray Crystallography; base; cofactor; conformation; conformational state; gene product; macromolecule; member; membrane structure; neuronal; oxidation reduction reaction; plasmalemma; potassium ion; programs; response; therapeutic development; voltage",Structural mechanism of K channel modulation by cellular redox state,,86392,ESTA,"Electrical Signaling, Ion Transport, and Arrhythmias Study Section",,5,390828,
7760619,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL086549-04,,NHLBI:380000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BURLINGTON,UNITED STATES,PATHOLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"HUBER, SALLY A.;",1863893;,5R01HL086549,02/01/2007,01/31/2011,"ATGN; Adenoviridae; Adenoviridae Infections; Adenovirus Infections; Adenoviruses; Adoptive Transfer; Amino Acids; Animals; Antigens; Autoimmune Status; Autoimmunity; Blood; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CSIF; CSIF-10; Capsid Proteins; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cells; Cells, CD4; Clinical; Coat Proteins; Coxsackie Viruses; Coxsackievirus; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Dendritic Cells; Disease; Disorder; Endothelial Cells; Enterovirus; Family Picornaviridae; Generations; Genetic Alteration; Genetic Change; Genetic defect; Glycolipids; Heart myocyte; Histocompatibility Complex; Histocompatibility Complices; IL-10; IL10; IL10A; INFLM; Immune; Immunity; Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; Infection; Inflammation; Interleukin 10 Precursor; Interleukin-10; Lymphocyte; Lymphocytic; MHC Receptor; Major Histocompatibility Complex; Major Histocompatibility Complex Receptor; Major Histocompatibility Complices; Mammals, Mice; Mediating; Mice; Modeling; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Mutation; Myocarditis; Myocardium; Myocytes, Cardiac; Natural immunosuppression; Nature; Organ System, Cardiovascular; Pathogenicity; Picornaviridae; Picornaviruses; Population; Predisposition; Receptors, Antigen, T-Cell; Recombinants; Regulatory T-Lymphocyte; Relative; Relative (related person); Reporting; Resistance; Reticuloendothelial System, Blood; Reticuloendothelial System, Spleen; Role; Spleen; Susceptibility; T-Cell Receptor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Thymus-Dependent Lymphocytes; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Vascular, Heart; Veiled Cells; Viral; Viral Coat Proteins; Viral Diseases; Viral Outer Coat Protein; Virus; Virus Diseases; Viruses, General; aminoacid; base; cardiac muscle; cardiomyocyte; circulatory system; cytokine; disease/disorder; experience; genome mutation; heart muscle; helper T cell; immunogen; immunosuppression; immunosuppressive; in vivo; killer T cell; lymph cell; macrophage; microbial; mutant; protein activation; resistant; self recognition (immune); social role; thymus derived lymphocyte; viral infection; virus infection",T reg Cells in Myocarditis,,86549,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,4,380000,
7809481,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL086719-04,,NHLBI:387815;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KAWUT, STEVEN M;",6674666;,5R01HL086719,01/01/2007,12/31/2010,"Active Follow-up; American; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood Plasma; Blood Pressure, High; Blood Vessels; C-reactive protein; Cardiac; Cardiovascular Diseases; Clinical; Coagulation Factor I; Coagulation Factor One; Cohort Studies; Concurrent Studies; Diagnosis; Differentiation Factor, B-Cell; Disease; Disorder; Dysfunction; Echocardiogram; Echocardiography; Endothelium; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethnic Origin; Ethnicity; Ethnicity aspects; FLR; Factor I; Factor One; Failure (biologic function); Fibrinogen; Functional disorder; Gender; HPGF; Heart; Heart failure; Hemostasis; Hemostatic Agents; Hemostatic function; Hemostatics; Hepatocyte-Stimulating Factor; Hybridoma Growth Factor; Hypercoagulability; Hypertension; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Inflammation; Inflammatory; Injury; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Investigators; Knowledge; Left; Left Ventricular Hypertrophy; Lung; Lung diseases; MGI-2; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Minority; Morbidity; Morbidity - disease rate; Morphology; Mortality; Mortality Vital Statistics; Myeloid Differentiation-Inducing Protein; NMR Imaging; NMR Tomography; National Heart, Lung, and Blood Institute; Nuclear Magnetic Resonance Imaging; Outcome; Participant; Pathway interactions; Patients; Phlebotomy; Physiopathology; Plasma; Plasmacytoma Growth Factor; Population; Pressure; Pressure- physical agent; Prevalence; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins, specific or class, C-reactive; Pulmonary Artery; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Hypertension; Pulmonary artery structure; Race; Racial Group; Reading; Research Personnel; Researchers; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Reticuloendothelial System, Serum, Plasma; Right Ventricular Dysfunction; Right Ventricular Function; Right Ventricular Hypertrophy; Right-On; Ristocetin Cofactor; Ristocetin-Willebrand Factor; Sampling; Serum, Plasma; Stocks, Racial; Symptoms; Syndrome; Thrombomodulin; Thrombophilia; Transthoracic Echocardiography; Vascular Diseases; Vascular Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Venous blood sampling; Ventricular; Ventricular Dysfunction, Right; Ventricular Ejection Fractions; Ventricular Function, Right; Zeugmatography; atheromatosis; atherosclerotic vascular disease; attributable death; attributable mortality; biomarker; blood vessel disorder; cardiac failure; cardiovascular disorder; cohort; cost; disease/disorder; failure; follow-up; heart sonography; hyperpiesia; hyperpiesis; hypertensive disease; improved; indexing; insight; interferon beta 2; lung disorder; medical attention; pathophysiology; pathway; pressure; prevent; preventing; programs; prospective; pulmonary; sound measurement; vWF; vascular; von Willebrand Factor; von Willebrand Protein; working group",Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis,,86719,CASE,Cardiovascular and Sleep Epidemiology Study Section,,4,387815,
7756677,R01,HL,5,,01/05/2010,12/31/2010,PA-07-070,5R01HL086879-02,,NHLBI:469656;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,,53,020520466,US,CA,92037,BURNHAM INSTITUTE FOR MEDICAL RESEARCH,"RUIZ-LOZANO, PILAR ;",2099842;,5R01HL086879,01/15/2009,12/31/2012,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 21+ years old; ATRA; Ablation; Adult; Agonist; All-trans retinoic acid; Antimorphic mutation; Asses; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Blood Vessels; Body Tissues; Breeding; Ca++ element; Calcium; Cardiac; Cardiac Myocytes; Cardiocyte; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Cells; Chemicals; Coagulation Factor IV; Collection; Congestive Cardiomyopathy; Development; Dilated Cardiomyopathy; Disease; Disorder; Disorder of muscle, unspecified; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Donkey; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysfunction; Equus asinus; Factor IV; Fibroblasts; Functional disorder; G Protein-Coupled Receptor Genes; G Protein-Coupled Receptor Signaling; GPCR; GPCR Signaling; GPR; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genotype; HTRPY; Heart failure; Heart myocyte; Histology; Human, Adult; Hyperplasia; Hyperplastic; Hypertrophy; Individual; Intracellular Communication and Signaling; Intracellular Second Messengers; Leiomyocyte; Ligands; Link; Mammals, Mice; Mediating; Mice; Mice, Mutant Strains; Modeling; Molecular; Molecular Interaction; Morphology; Murine; Mus; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscle, Cardiac; Muscle, Heart; Muscular Diseases; Mutant Strains Mice; Mutation; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes; Myocytes, Cardiac; Myocytes, Smooth Muscle; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Names; Nuclear Receptors; Orphan; Pathway interactions; Phenotype; Physiopathology; Play; Precipitation; Receptor Protein; Regulation; Repression; Retinoic Acid; Retinoic Acid Agent; Retinoic Acid and Derivatives; Retinoid Receptor; Retinoids; Role; Second Messenger Systems; Second Messengers; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Specificity; System; System, LOINC Axis 4; Testing; Therapeutic; Tissues; Trans Vitamin A Acid; Transducers; Tretinoin; Tretinoinum; Ventricular; Vitamin A Acid; adult human (21+); all-trans-Retinoic Acid; all-trans-Vitamin A acid; base; biological signal transduction; cardiac failure; cardiac muscle; cardiomyocyte; cardiovascular disorder; disease/disorder; genome mutation; heart muscle; in vivo; insight; mouse model; mouse mutant; muscular disorder; mutant; myocardium disorder; new therapeutic target; novel; pathophysiology; pathway; public health relevance; receptor; second messenger; social role; trans-Retinoic Acid; vascular",Genetic Rescue of Retinoid-Induced Dysfunction, Project Narrative Here we propose the study of the molecular mechanism by which reduction in GPCR signaling rescues abnormal cardiac function. Completion of this proposal will set up the groundwork for novel therapies to cardiovascular disease.,86879,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,2,469656,
7760973,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL086883-03,,NHLBI:390000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"ALTEMEIER, WILLIAM A;",2125248;,5R01HL086883,02/01/2008,01/31/2013,"AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; ARDS; ARDS, Human; ARDSs, Human; ATF; Activator Protein-1; Acute; Acute Pulmonary Injury; Adult RDS; Adult Respiratory Distress Syndrome; Agonist; Alveolar; Animal Welfare; Assay; Attenuated; Bacteremia; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cell Communication and Signaling; Cell Signaling; Cell Wall; ChIP (chromatin immunoprecipitation); Country; Critical Illness; Critically Ill; Cytokines, Chemotactic; DNA Binding; DNA Binding Interaction; Data; Defect; Development; Differential Gene Expression; Distal; Dose; EC 2.7; EC 2.7.2-; Ecological impact; Enhancer-Binding Protein AP1; Environment; Environmental Impact; Environmental air flow; Epithelial Cells; Equipment; Ethics Committees, Research; Exposure to; Extracellular Signal-Regulated Kinases; Figs; Figs - dietary; Future; Gene Targeting; Gene Transcription; Generations; Genes; Genetic Transcription; Goals; Gram-Negative Bacteria; Homologous Chemotactic Cytokines; IACUC; IFN; IL1 Receptors; INFLM; IRBs; Immune response; Immunomodulation; Impact, Environmental; Individual; Inflammation; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; Interferons; Interleukin-1 Receptors; International; Intervention; Intervention Strategies; Intracellular Communication and Signaling; JN kinase kinase; JNK; JNK kinase; JNK-activating protein kinase; JNK1; JNK1A2; JNK21B1/2; JNKK; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Jun amino-terminal kinase kinase; Kinases; Knowledge; LPS; Lead; Ligands; Link; Lipopolysaccharides; Literature; Lung; Lung Injury, Acute; MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK8; MAPK8 gene; Mammals, Mice; Measures; Mechanical ventilation; Messenger RNA; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Modeling; Molecular; Molecular Interaction; Murine; Mus; Myelogenous; Myeloid; Myeloid Cells; Nuclear Translocation; PRKM8; Pathogenesis; Pathway interactions; Patients; Pattern; Pattern Recognition; Pattern Recognition/Display/Analysis; Pb element; Phosphotransferases; Pneumonia; Pneumonitis; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Protein Subunits; Pulmonary Inflammation; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; Receptor Signaling; Receptors, IL-1; Receptors, Interleukin-1; Recruitment Activity; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System, Lung; Role; SAPK1; SIS cytokines; Safety; Sequence-Specific Posttranscriptional Gene Silencing; Shock Lung; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; TIL4; TLR protein; TLR2; TLR2 receptor; TLR3; TLR3 protein, human; TLR3 receptor; TLR4 receptor; Targetings, Gene; Testing; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Toll-4 receptor; Toll-Like Receptor 2; Toll-Like Receptor 3; Toll-like receptor 3, human; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; Transcription; Transcription Factor AP-1; Transcription, Genetic; Transgenic Mice; Transphosphorylases; Ventilation; Ventilator; Ventilator-induced lung injury; Vertebrate Animals; Vertebrates; abstracting; activating transcription factor; acute lung injury; adapter protein; bacteraemia; base; biological signal transduction; c jun; c-jun Gene; cell type; chemoattractant cytokine; chemokine; chromatin immunoprecipitation; design; designing; experiment; experimental research; experimental study; expiration; genetic promoter element; heavy metal Pb; heavy metal lead; host response; human TLR3 protein; human subject; immune modulation; immunologic reactivity control; immunoregulation; immunoresponse; improved; in vivo; injured; interventional strategy; lung injury; mRNA; mechanical respiratory assist; microbial; mouse model; novel; pathogen; pathway; programs; pulmonary; recruit; research study; response; social role; standard of care; toll-like receptor 4; transcription factor; vertebrata",Mechanisms of innate immune response modulation by mechanical ventilation,,86883,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,3,390000,
7797510,R01,HL,5,,02/01/2010,01/31/2011,PA-05-046,5R01HL086934-04,,NHLBI:370000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,PSYCHOLOGY,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"EASTMAN, CHARMANE I;",1900580;,5R01HL086934,02/05/2007,01/31/2011,"Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Advanced Sleep Phase Syndrome; Advanced Sleep Phase Syndrome (ASPS); Advertisements; Aged 65 and Over; Aves; Avian; Beds; Birds; Body Temperature; Boxing; Broken sleep; Chronic Insomnia; Circadian Rhythms; Clinic; Delayed Sleep Phase Syndrome; Difficulty in sleep maintenance; Difficulty staying asleep; Distress; Diurnal Rhythm; Dose; Elderly; Elderly, over 65; Fitful sleep; Future; General Population; General Public; Home; Home Remedy; Home environment; Human; Human, General; Industry; Insomnia, Chronic; Interrupted sleep; Jet Lag; Jet Lag Syndrome; Jetlag; Jetlag Syndrome; Light; Man (Taxonomy); Man, Modern; Measures; Melatonin; Middle Insomnia; Night waking; Nyctohemeral Rhythm; Out-patients; Outpatients; Owls; Patients; Phase; Phase response curves; Photoradiation; Photoreceptor Cell; Photoreceptors; Photoreceptors, Vertebrate; Photosensitive Cell; Pill; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Recommendation; Relative; Relative (related person); Remedy, Home; Rods and Cones; Running; SCHED; Schedule; Schools; Seasonal Affective Disorder; Seasonal Mood Disorder; Shapes; Shift-Work Sleep Disorder; Sleep; Sleep Deprivation; Sleep Disorder, Shift-Work; Sleep Disorders; Sleep Wake Cycle; Sleep maintenance insomnia; Societies; Stimulus; Strigiformes; Symptoms; System; System, LOINC Axis 4; Testing; Time; Time Zone Change Syndrome; Time Zone Syndrome; Travel; Twenty-Four Hour Rhythm; Vertebrate Photoreceptors; Visual Receptor; Work; adult youth; advanced age; alertness; application in practice; base; circadian; circadian clock; circadian pacemaker; circadian process; cost; daily biorhythm; day shift; diurnal variation; elders; gastrointestinal; geriatric; innovate; innovation; innovative; late life; later life; light treatment; night shift; night work; novel; older adult; older person; onset of sleep; pill (pharmacologic); practical application; programs; response; seasonal depression; senior citizen; shift work; sleep onset; sleep problem; young adult",Phase response curves for home remedies to treat circadian misalignment,,86934,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,4,370000,
7751811,R01,HL,5,,01/01/2010,12/31/2010,,5R01HL086959-04,,NHLBI:357968;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,IRVINE,UNITED STATES,BIOCHEMISTRY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"HUGHES, CHRISTOPHER C. W.;",1895684;,5R01HL086959,01/19/2007,12/31/2010,"Acute; Address; Antimorphic mutation; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Blood; Blood Vessels; Blood capillaries; CLG4; CLG4A; Cancers; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Signaling; Cell surface; CellLine; Cells; Chromatin Structure; Collagen; DIF; Data; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down-Regulation; Down-Regulation (Physiology); Downregulation; Elements; Embryo; Embryonic; Endothelial Cells; Event; Extracellular Matrix, Integrins; Fetal Liver Kinase-1; Fibrin; Figs; Figs - dietary; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Gel; Gene Expression; Gene Targeting; Genes; INFLM; Implant; In Vitro; Inflammation; Inflammation Mediators; Integrins; Intracellular Communication and Signaling; Investigators; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Knowledge; Ligands; MMP2; MMP2 gene; MMPs; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Maps; Matrix Metalloproteinases; Mice; Mining; Minings; Modeling; Molecular Interaction; Murine; Mus; Nucleus; Operation; Operative Procedures; Operative Surgical Procedures; Peptide Domain; Phenotype; Plug-in; Process; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Domains; Proteins; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Blood; Role; Signal Transduction; Signal Transduction Systems; Signaling; Surgical; Surgical Interventions; Surgical Procedure; TBE-1; TNF; TNF A; TNF gene; TNFSF2; Targetings, Gene; Tertiary Protein Structure; Testing; Tumor Necrosis Factor Gene; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptors; VEGFR; VEGFR-2; VEGFR2; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-2; Vascular Permeability Factor Receptor; Work; adapter protein; angiogenesis; biological signal transduction; capillary; cultured cell line; falls; fight against; gene product; in vivo; jagged-1; jagged1 protein; malignancy; matrigel; neoplasm/cancer; new growth; notch; notch protein; notch receptors; programs; social role; surgery; vascular",Bidirectional Notch Signaling and Angiogenesis,,86959,CDD,Cardiovascular Differentiation and Development Study Section,,4,357968,
7760966,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL087017-05,,NHLBI:275000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,TYLER,UNITED STATES,NONE,01,800772337,US,TX,75708,UNIVERSITY OF TEXAS HLTH CTR AT TYLER,"JI, HONG-LONG ;",7930348;,5R01HL087017,02/01/2007,01/31/2012,"21+ years old; Adult; Alveolar; Alveolar Cell; Amiloride; Amino Acids; Arts; Biochemical; Biological; Biotinylation; Cardiac Diseases; Cardiac Disorders; Cations; Cell surface; Cells; Confocal Microscopy; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Data; Depression; Development; Dropsy; ENaC; ENaC (epithelial Na+ channel); Edema; Electrodes; Epithelial; Epithelial Cells; GUCY; Gases; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Heart Diseases; Human; Human, Adult; Human, General; Hydrops; Hydrostatic Pressure; Investigators; Ion Channels, Sodium; Ions; Liquid substance; Lung; Lung Alveolar Epithelia; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Mental Depression; Methods and Techniques; Methods, Other; Mice; Microscopy, Confocal; Molecular; Murine; Mus; Oocytes; Ovocytes; PKG; Patch-Clamp Technics; Patch-Clamp Techniques; Pathway interactions; Patients; Permeability; Physiologic; Physiological; Plasma Proteins; Probability; Property; Property, LOINC Axis 2; Protein Kinase G; Proteins; Pulmonary Edema; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-; RNA Splicing; RNA, Small Interfering; Regulation; Research; Research Personnel; Researchers; Respiratory System, Lung; Site; Small Interfering RNA; Sodium Channel; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase; Splicing; Structure of alveolar epithelium; Techniques; Testing; Time; Transfection; Variant; Variation; Xenopus oocyte; Zinc; Zn element; adult human (21+); alveolar epithelium; aminoacid; base; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; combat; epithelial Na+ channel; fetal; fluid; gene product; guanosine 3'5' monophosphate; heart disorder; in vivo; interest; liquid; lung edema; monolayer; mutant; new therapeutics; next generation therapeutics; nitric oxide receptor; nitric oxide-sensitive guanylyl cyclase; novel therapeutics; pathway; protein expression; pulmonary; sGC; sGC protein; siRNA; voltage clamp",Regulation of lung epithelial sodium channels by cGMP,,87017,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,5,275000,
7763819,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL087136-04,,NHLBI:257250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,KANSAS CITY,UNITED STATES,ANATOMY/CELL BIOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"CZIROK, ANDRAS ;",8583167;,5R01HL087136,02/01/2007,01/31/2012,"3-D structure; 3-dimensional structure; 3D structure; Angioblast; Antibodies; Area; Assay; Behavior; Bioassay; Biologic Assays; Biological Assay; Blood Vessels; Cell Adhesion; Cell Attachment; Cell Locomotion; Cell Migration; Cell Movement; Cell-Extracellular Matrix; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Adhesion; Cellular Migration; Clinical; Cold-Insoluble Globulins; Complex; Computer Simulation; Computerized Models; Confocal Microscopy; Cues; Data; Development; Distal; Dysfunction; ECM; Embryo Development; Embryogenesis; Embryonic Development; Endothelial Cells; Extracellular Matrix; Extracellular Matrix, Integrins; FN1; FNZ; Fibronectin 1; Fibronectins; Filament; Fluorescence; Functional disorder; Generalized Growth; Goals; Growth; Image; Integrins; Invaded; Investigators; LETS Proteins; Label; Large External Transformation-Sensitive Protein; Maintenance; Maintenances; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Microscopy; Microscopy, Confocal; Microscopy, Differential Interference Contrast; Microscopy, Nomarski Interference Contrast; Modeling; Models, Computer; Molecular; Motility; Motility, Cellular; Nomarski Interference Contrast Microscopy; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Optics; Pattern; Physiologic; Physiological; Physiopathology; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Reagent; Receptor Protein; Research Personnel; Researchers; Resolution; Role; Simulation, Computer based; Spatial Distribution; Speed; Speed (motion); Structure; System; System, LOINC Axis 4; Therapeutic; Tissue Engineering; Tissue Growth; Vascular Endothelial Cell; Vascularization; Width; alpha 2-Surface Binding Glycoprotein; cell assembly; cell motility; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; engineered tissue; imaging; improved; in silico; in vivo; mathematical model; mathematical modeling; ontogeny; particle; pathophysiology; progenitor; programs; receptor; response; self organization; social role; three dimensional structure; tumor growth; vascular; vasculogenesis; virtual simulation",Role of fibronectin in vascular plexus self-organization during embryogenesis,,87136,CDD,Cardiovascular Differentiation and Development Study Section,,4,257250,
7760164,R01,HL,5,,02/01/2010,01/31/2011,,5R01HL087166-04,,NHLBI:371250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BALTIMORE,UNITED STATES,PEDIATRICS,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"VISCARDI, ROSE MARIE;",1925188;,5R01HL087166,02/01/2007,01/31/2012,"0-6 weeks old; 3-10C; AMCF-I; ASPR; Acute; Acute Pulmonary Injury; Agonist; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Archives; Aspirate; Aspirate substance; BPD; Baboons; Bacteria; Blood; Blood monocyte; Bone Marrow; Bronchopulmonary Dysplasia; CXCL8; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chronic; Chronic lung disease; DKFZp547I0610; DKFZp564I0682; Data; Defect; Development; Eperythrozoon; Fibrosis; Frequencies (time pattern); Frequency; GCP-1; GCP1; Generations; Genes; Genetic Polymorphism; Genital; Genital system; Haemobartonella; Heterogeneity; Human; Human, General; IL-8; IL8; IL8 gene; INFLM; Immune response; Immune system; In Vitro; Infant, Newborn; Infant, Premature; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Institution; Intracellular Communication and Signaling; Investigators; K60; KIAA0012; LECT; LPS; LUCT; LYNAP; Laboratories; Lead; Life; Lipopolysaccharides; Lung; Lung Inflammation; Lung Injury, Acute; Lung diseases; MDNCF; MONAP; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Mice; Modeling; Molecular; Morphology; Murine; Mus; Mycoplasma; NAF; Neutrophil Infiltration; Neutrophil Recruitment; Newborn Infant; Newborns; Papio; Papios; Pb element; Pneumonia; Pneumonitis; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Predisposition; Premature Infant; Process; Production; Programs (PT); Programs [Publication Type]; Public Health; Pulmonary Body System; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; Pulmonary Organ System; Receptor Gene; Receptor Protein; Receptor Signaling; Research Personnel; Researchers; Respiratory Disease; Respiratory Disorder; Respiratory System; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Reticuloendothelial System, Blood; Reticuloendothelial System, Bone Marrow; Risk; Risk Factors; Role; Rosa; Rose; SCYB8; SNP; SNPs; Savanna Baboons; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Susceptibility; T-Mycoplasma; TIL4; TLR protein; TLR1; TLR1 gene; TLR2; TLR2 gene; TLR2 receptor; TLR4; TLR4 gene; TLR6; TLR6 gene; TOLL; TSG-1; Testing; Toll-Like Receptor 2; Toll-like receptors; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like 4 Gene; Toll/Interleukin 1 Receptor-Like Protein 4; Tracts, Respiratory; Ureaplasma; Ureaplasma Infections; Ureaplasma urealyticum; Ureaplasma urealyticum biovar 2; acute lung injury; angiogenesis; b-ENAP; biological signal transduction; body system, allergic/immunologic; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; cohort; cultured cell line; cytokine; fighting; functional outcomes; hToll; heavy metal Pb; heavy metal lead; host response; immunoresponse; in vivo; infant chronic lung disease; interstitial; lung development; lung disorder; lung injury; macrophage; monocyte; neonatal chronic lung disease; neonatal lung injury; neonate; newborn chronic lung disease; newborn human (0-6 weeks); novel therapeutic intervention; organ system, allergic/immunologic; overexpression; pathogen; polymorphism; premature; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; prevent; preventing; programs; public health medicine (field); pulmonary; receptor; respiratory tract; rsc786; social role; tool; ureaplasma infected; urogenital system (genital part)",Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung Injury,,87166,ZRG1,Special Emphasis Panel,,4,371250,
7747956,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL087308-03,,NHLBI:371828;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBIA,UNITED STATES,PHARMACOLOGY,09,153890272,US,MO,65211,UNIVERSITY OF MISSOURI-COLUMBIA,"DAVIS, GEORGE E;",1871485;,5R01HL087308,01/01/2008,12/31/2011,"Address; Adherens Junction; Adhering Junction; Adhesive Junction; Adventitial Cell; Anchoring Junction; Animal Welfare; Antiproteases; Area; Assay; Attention; Basement membrane; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biological Models; Biology; Blood; Blood Vessels; Body Tissues; Brachydanio rerio; CD44; CD44 gene; Cancers; Cannulas; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell membrane; Cell surface; Cell-Extracellular Matrix; CellLine; Cells; Chimera; Chimera organism; Collagen; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Computer Programs; Computer software; Country; Cytoplasmic Membrane; Danio rerio; Data; Development; Diabetes Mellitus; Distal; ECM; Ear; Ear structure; Ecological impact; Editorial Comment; Editorial Comment (PT); Endopeptidase Inhibitors; Endothelial Cells; Endothelial Cells, Lymphatic; Environment; Environmental Impact; Equilibrium; Equipment; Esteroproteases; Ethics Committees, Research; Event; Extracellular Matrix; Extracellular Matrix, Integrins; Fibrin; Figs; Figs - dietary; Filopodia; Fluorescence Microscopy; GFP; Genes; Green Fluorescent Proteins; Human; Human TIMP-3; Human Tissue Inhibitor of Metalloproteinase-3; Human, General; IACUC; IRBs; Image; Immune Precipitation; Immunoprecipitation; Impact, Environmental; In Vitro; Individual; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; Integrin Binding; Integrins; International; Intracellular Communication and Signaling; Investigation; Knock-out; Knockout; Knockout Mice; Laboratories; Leiomyocyte; Link; Lymphatic; Lymphatic Endothelial Cells; MDU3; MMP-X1; MMP14 gene; MMPs; MT1-MMP; MTMMP1; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Membrane; Mesenteric; Mesentery; Metallopeptidases; Metalloproteases; Metalloproteinases; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Model System; Modeling; Models, Biologic; Molecular; Molecular Interaction; Morphogenesis; Movement; Murine; Mus; Myocytes, Smooth Muscle; Neck; Null Mouse; Omental Fat; Omentum; Pathogenesis; Pathway interactions; Peptidase Inhibitors; Peptidases; Peptide Hydrolase Inhibitors; Peptide Hydrolases; Peptide Peptidohydrolase Inhibitors; Pericapillary Cell; Pericytes; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Perivascular Cell; Pgp1; Phenotype; Plasma Membrane; Play; Position; Positioning Attribute; Postcapillary Venule; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protease Antagonists; Protease Inhibitor; Proteases; Protein Cleavage; Proteinase Inhibitors; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Proteomics; Published Comment; Publishing; Pump; RNA, Small Interfering; Reagent; Recombinants; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Blood; Role; Rouget Cells; Series; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Software; Structure; Structure of postcapillary venule; System; System, LOINC Axis 4; TIMP-3; Techniques; Testing; Time; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases; Tissues; Tube; Tubular; Tubular formation; Vacuole; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; Zebra Danio; Zebra Fish; Zebrafish; abstracting; angiogenesis; balance; balance function; base; biological signal transduction; body movement; cell type; computer program/software; cultured cell line; diabetes; experiment; experimental research; experimental study; expiration; gene product; hTIMP; human disease; human subject; imaging; in vivo; in vivo Model; interest; knock-down; knockout animal; malignancy; membrane structure; metalloproteinase (general); neoplasm/cancer; new technology; pathway; peripheral blood vessel disorder; plasmalemma; postcapillary venule; programs; protein expression; research study; response; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; siRNA; social role; subcutaneous; tool; vascular; vasculogenesis; vertebrata",Molecular Control of EC Lumen Formation by MT1-MMP,,87308,VCMB,Vascular Cell and Molecular Biology Study Section,,3,371828,
7626008,R01,HL,5,,01/01/2010,12/31/2010,HL-06-012,5R01HL087681-03,,NHLBI:740842;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"STEINBERG, MARTIN H.;",2416414;,5R01HL087681,05/25/2007,12/31/2010,"100+ years old; Abbreviations; Academic Medical Centers; Affect; Age; Aging; Amentia; Apoplexy; Assay; Bayesian Networks; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Blood Pressure; Blood Pressure, High; Bone necrosis; Boston; Candidate Disease Gene; Candidate Gene; Cardiovascular Diseases; Centenarian; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; City of Boston; Clinical; Complex Genetic Trait; DISSEC; DNA Alteration; DNA mutation; Data; Dehydrogenases; Dementia; Development; Disease; Disorder; Dissection; Elements; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Equilibrium; Fetal Hemoglobin; Framingham Heart Study; GWAS; Gene Alteration; Gene Mutation; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Variation; Genetic mutation; Genotype; Globin; Glomerular Filtration Rate; Hb SS disease; HbSS disease; Hemoglobin; Hemoglobin F; Hemoglobin S; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hereditary; Heterogeneity, Population; Hydroxycarbamid; Hydroxycarbamide; Hypertension; Hypertension, Pulmonary; Inherited; Investigators; Laboratories; Leg Ulcer; Length of Life; Linkage Disequilibrium; Linkage Disequilibriums; Longevity; Lower Extremity Ulcer; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Modeling; Mononitrogen Monoxide; Multicenter Studies; Nature; New England; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Northeastern United States; Osteonecrosis; Oxidoreductase; Participant; Pathway interactions; Patients; Phenotype; Planning Methodology; Planning Technic; Planning Techniques; Play; Polymorphism, Single Base; Population; Population Heterogeneity; Population Study; Predisposition; Premature Mortality; Priapism; Programs (PT); Programs [Publication Type]; Pulmonary Hypertension; Reductases; Relative; Relative (related person); Research; Research Personnel; Researchers; Risk; Role; SNP; SNPs; Senescence; Sequence Alteration; Severities; Severity of illness; Sickle Cell Anemia; Sickle Hemoglobin; Single Nucleotide Polymorphism; Stroke; Study Subject; Susceptibility; Techniques; Transcend; University Medical Centers; Urea, hydroxy-; Validation; Variant; Variation; Variation (Genetics); Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; abstracting; age dependent; age related; allelic variant; association test; balance; balance function; base; brain attack; cardiac hypertension; cardiovascular disorder; centenarian human (100+); cerebral vascular accident; cognitive function; cohort; computer based statistical methods; cooperative study; disease risk; disease severity; disease/disorder; disorder risk; diverse populations; endothelial cell derived relaxing factor; functional status; genetic association; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heart disease hypertension; heart disorder hypertension; heart hypertension; heterogeneous population; hydroxyurea; hyperpiesia; hyperpiesis; hypertensive cardiomyopathy; hypertensive disease; hypertensive heart disease; hypertensive heart disorder; indexing; life span; lifespan; network models; novel; offspring; p-Globin; pathway; prognostic; programs; senescent; sickle cell disease; sickle disease; sicklemia; social role; statistical methods, computer based; stroke; whole genome association studies; whole genome association study",Genome-Wide Association Studies in Sickle Cell Anemia and in Centenarians,,87681,ZHL1,Special Emphasis Panel,,3,740842,
7755443,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL087862-03,,NHLBI:150000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ROBBINS, JEFFREY ;",1886744;,5R01HL087862,02/01/2008,01/31/2011,"21+ years old; APAF1 Protein; Ablation; Address; Adult; Age; Age Group Unspecified; Amyloid; Amyloid Substance; Animal Welfare; Animals; Antibodies; Apaf-1; Apaf-1 protein; Apaf-1L protein; Apaf-3 protein; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Apoptotic Protease Activating Factor; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; Back; Bibliography; Biological; Biological Models; Breeding; CASP-3; CASP3; CASP9 Protein; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Cardiac Diseases; Cardiac Disorders; Cardiac Myocytes; Cardiocyte; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiovascular Diseases; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase 9, Apoptosis-Related Cysteine Protease; Causality; Cell Death, Programmed; Cell-Death Protease; Childhood; Collection; Congestive Cardiomyopathy; Control Animal; Country; Crystallins; Cysteine Protease CPP32; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Desmin; Dilated Cardiomyopathy; Disease; Disorder; Disorder of muscle, unspecified; Dorsum; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Etiology; FLR; Face; Failure (biologic function); Ferricytochrome c; Ferrocytochrome c; Figs; Figs - dietary; Gender; Gene Transcription; Generations; Genetic; Genetic Transcription; Goals; Heart; Heart Diseases; Heart failure; Heart myocyte; Human; Human, Adult; Human, General; IACUC; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; ICE-like protease; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knock-out; Knockout; Knockout Mice; Lens Proteins; Link; Literature; Mammals, Mice; Man (Taxonomy); Man, Modern; Mch6 protein; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mitochondria; Modality; Model System; Modeling; Models, Biologic; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscular Diseases; Mutant Strains Mice; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocytes, Cardiac; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Natural regeneration; Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Null Mouse; PARP Cleavage Protease; Pathway interactions; Patients; Peripheral; Phase; Play; Population; Prevention program; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Proteins; RNA Expression; Race; Racial Group; Recovery; Regeneration; Research; Research Ethics Committees; Research Resources; Resources; Role; SCA-1; SREBP Cleavage Activity 1; Sampling; Skeletin; Staging; Stocks, Racial; Structure; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicities; Transcription; Transcription, Genetic; Transgenic Organisms; Vertebrate Animals; Vertebrates; Yama; Yama protein; abstracting; adult human (21+); age group; apoptotic protease-activating factor 1; base; cardiac failure; cardiomyocyte; cardiovascular disorder; caspase; caspase-3; caspase-9; clinical data repository; clinical data warehouse; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; cytochrome c; data repository; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; expiration; facial; failure; gene product; heart disorder; human subject; insight; knockout animal; mitochondrial; mitochondrial membrane; mouse mutant; muscular disorder; mutant; myocardium disorder; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; pathway; pediatric; pre-s proteins; prevent; preventing; pro-apoptotic protein; programs; protein S precursor; regenerate; relational database; social role; therapeutic target; transgene expression; transgenic; vertebrata; vitamin K-dependent protein S precursor",Cardiomyocyte Toxicity and Heart Failure in Desmin Related Cardiomyopathy,,87862,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,3,150000,
7761681,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL087867-03,,NHLBI:378750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHARLOTTESVILLE,UNITED STATES,PHYSIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"OWENS, GARY K;",6402591;,5R01HL087867,02/01/2008,01/31/2013,"AGEPC receptor; Actins; Address; Animal Welfare; Antigens, Differentiation; Arterial Fatty Streak; Assay; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Bibliography; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Blood Vessels; Blood monocyte; Blotting, Western; Boxing; CCL2; CCL2 gene; Carotid Arteries; Cell Culture System; Cell Differentiation; Cell Differentiation process; Cell-Extracellular Matrix; Choline Chloride Dihydrogen Phosphate; Choline Phosphate; Choline Phosphate Chloride; Chromatin Structure; Clinical; Collagen; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Cues; DIF; Development; Differentiation Antigens; Differentiation Markers; Differentiation and Growth; Disease; Disorder; ECM; ELK-1; ELK1; ELK1 gene; Ecological impact; Editorial Comment; Editorial Comment (PT); Elements; Endothelial Cells; Environment; Environmental Factor; Environmental Impact; Environmental Risk Factor; Equilibrium; Equipment; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride; Ethics Committees, Research; Extracellular Matrix; Figs; Figs - dietary; GDCF-2; GDCF-2 HC11; Gene Down-Regulation; Genes; Goals; HC11; Hybrids; IACUC; IRBs; Impact, Environmental; In element; Indium; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Laboratories; Lead; Leiomyocyte; Lesion; Ligand Binding Protein; MCAF; MCP-1; MCP1; MGC9434; MMPs; MTGN; Marker Antigens; Markers, Differentation; Marrow monocyte; Matrix Metalloproteinases; Mediating; Mice, Transgenic; Mitogens; Molecular; Molecular Interaction; Myocytes, Smooth Muscle; Nature; PAF receptors; PDGF; PTAFR protein; Pathogenesis; Pattern; Pb element; Phosphatides; Phosphocholine; Phospholipids; Phosphorylation; Phosphorylcholine; Phosphorylcholine Chloride; Platelet-Derived Growth Factor; Play; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Published Comment; RNA, Small Interfering; Receptor Signaling; Recommendation; Regulatory Element; RegulatoryElement; Research; Research Ethics Committees; Research Resources; Resources; Role; Rupture; SCYA2; SMC-CF; Screening procedure; Series; Signal Pathway; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Staging; Streaks, Arterial Fatty; TNF; TNF A; TNF gene; TNFSF2; Testing; Thrombosis; Time; Tissue Inhibitor of Metalloproteinases; Transcription Regulation; Transcription Repression; Transcriptional Control; Transcriptional Regulation; Transcriptional Repression; Transgenic Mice; Transgenic Organisms; Tumor Necrosis Factor Gene; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Western Blotting; Western Blottings; Western Immunoblotting; Yeasts; abstracting; atherogenesis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; balance; balance function; calponin; disease/disorder; end stage disease; environmental risk; experiment; experimental research; experimental study; expiration; gene repression; heavy metal Pb; heavy metal lead; human subject; improved; in vivo; inhibitor; inhibitor/antagonist; insight; macrophage; migration; monocyte; myocardin; new therapeutic target; novel; platelet activating factor receptor; programs; protein blotting; research study; response; screening; screenings; siRNA; social role; transgenic; vascular; vertebrata; vulnerable plaque",Role of Oxidized Phospholipids in Phenotypic Switching of Smooth Muscle Cells (SM,,87867,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,3,378750,
7765497,R01,HL,5,,03/01/2010,02/28/2011,PA-07-070,5R01HL088128-03,,NHLBI:366000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,NONE,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"MARTIN, EMIL ;",8648745;,5R01HL088128,03/07/2008,02/28/2013,"1,2,3-Propanetriol, trinitrate; Activity Cycles; Affect; Affinity; Automobile Driving; BP control; Binding; Binding (Molecular Function); Biochemical; Blood Pressure; Blood Pressure, High; Blood Vessels; Cell Communication and Signaling; Cell Signaling; Cells; Closure by Ligation; Complex; Conflict; Conflict (Psychology); Confusion; Confusional State; Coupled; Coupling; Cyclic GMP; D-Glucitol, 1,4[{..}]3,6-dianhydro-; Data; Devices; Distal; Drivings, Automobile; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Elements; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Enzyme Activation; Enzymes; Event; Exogenous Factors; Factor Analyses; Factor Analysis; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Fluorescence; GTP; GUCY; Gases; Glyceryl Trinitrate; Goals; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine Triphosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Heme; Heme Iron; Heme Proteins; Heme b; Hemeproteins; Hypertension; In Vitro; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Isosorbide; Kinetic; Kinetics; Knowledge; Ligands; Ligation; Literature; Mammals, Mice; Measurement; Mental Confusion; Methods; Mice; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Mono-S; MonoS; Mononitrogen Monoxide; Murine; Mus; Muscle Relaxation; Muscle relaxation phase; Muscle, Involuntary; Muscle, Smooth; Neural Transmission; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nitroglycerin; O element; O2 element; Optics; Organism; Outcome; Output; Oxidation-Reduction; Oxygen; Oxyhemoglobin; Paramagnetic Resonance; Pathway interactions; Patients; Phase; Physiologic; Physiological; Physiology; Platelet aggregation; Process; Property; Property, LOINC Axis 2; Proteins; Protocols, Treatment; Protoheme; Protoheme IX; Purine Nucleotides; RGM; Receptor Protein; Redox; Regimen; Regulation; Rest; Role; Science; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Smooth muscle (tissue); Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase; Specificity; Spectrometry; Spectroscopy, ESR; Staging; Students; Synaptic Transmission; Testing; Therapeutic; Thinking; Thinking, function; Training; Treatment Protocols; Treatment Regimen; Treatment Schedule; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; age dependent; age related; angiogenesis; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; cGMP; cGMP production; conformation; conformational state; design; designing; driving; electron paramagnetic resonance spectroscopy; endothelial cell derived relaxing factor; enzyme activity; extracellular; ferroheme; gene product; graduate student; guanosine 3'5' monophosphate; hemoprotein; hyperpiesia; hyperpiesis; hypertensive disease; iNO; improved; inhaled nitric oxide; innovate; innovation; innovative; insight; interest; interventional strategy; isocyanide; living system; mutant; nano sensing; nano sensors; nanosensing; nanosensors; neonatal pulmonary hypertension; newborn pulmonary hypertension; nitric oxide receptor; nitric oxide-sensitive guanylyl cyclase; novel; oxidation reduction reaction; pathway; post-doctoral training; postdoctoral training; protein complex; pulmonary hypertension in neonate; pulmonary hypertension in newborn; pulmonary hypertension of neonate; pulmonary hypertension of newborn; receptor; response; sGC; sGC protein; scaffold; scaffolding; sensor; social role; vascular",Modulation of soluble guanylyl cyclase by endogenous elements and exogenous facto,,88128,HM,Hypertension and Microcirculation Study Section,,3,366000,
7758225,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL088435-03,,NHLBI:345375;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,ANESTHESIOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"MARRELLI, SEAN P;",2089169;,5R01HL088435,02/01/2008,01/31/2013,"5-Oxazolecarboxylic acid, 2-(6-(bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-; ATP; Adenosine 5'-(tetrahydrogen triphosphate); Adenosine Triphosphate; Adenylpyrophosphate; Agonist; Animal Welfare; Apoplexy; Arteries; Bibliography; Blood Coagulation Factor IV; Blood Serum; Blood Vessels; Blood flow; Brain; Burn injury; Burns; Ca++ element; Calcium; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cations; Cations, Divalent; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cerebral Arteries; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Coagulation Factor IV; Coloring Agents; Common Rat Strains; Confusion; Confusional State; Country; Coupling; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Data; Divalent Cations; Dyes; EC 3.1.1.4; ECSF; Ecological impact; Encephalon; Encephalons; Endothelial Cells; Endothelium; Environment; Environmental Impact; Epoetin; Equipment; Erythropoietin; Ethics Committees, Research; Experimental Designs; Factor IV; Female; Fura-2; GFAC; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Heart; Heating; IACUC; IHC; IRBs; Immunohistochemistry; Immunohistochemistry Staining Method; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigators; Lead; Lecithinase A2; Mammals, Rats; Manuscripts; Measures; Mediating; Membrane Potentials; Mental Confusion; Methods and Techniques; Methods, Other; Middle Cerebral Artery; Nervous System, Brain; Organ Culture; Organ Culture Techniques; Organ System, Cardiovascular; PLA2; Pathway interactions; Pb element; Phospholipase A2; Physiologic; Physiological; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; RT-PCR; RTPCR; Rat; Rattus; Receptor Protein; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Resting Potentials; Reverse Transcriptase Polymerase Chain Reaction; Role; Sequence-Specific Posttranscriptional Gene Silencing; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Source; Specific qualifier value; Specified; Stroke; Structure of cerebral artery; Structure of middle cerebral artery; Suggestion; Survey Instrument; Surveys; System; System, LOINC Axis 4; Techniques; Testing; Transcript; Transmembrane Potentials; Vascular Accident, Brain; Vascular, Heart; Vertebrate Animals; Vertebrates; abstracting; biological signal transduction; brain attack; cerebral artery; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; cerebrovascular; channel blockers; circulatory system; erythrocyte colony stimulating factor; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; hematopoietin; human subject; lecithinase A; member; middle cerebral artery; new therapeutics; next generation therapeutics; novel therapeutics; patch clamp; pathway; phosphatidase; phosphatidolipase; phosphatidylcholine 2 acylhydrolase; programs; receptor; research study; response; reverse transcriptase PCR; siRNA; social role; stroke; tool; vascular; vascular bed; vertebrata",Mechanisms of Endothelial Cell Hyperpolarization,,88435,VCMB,Vascular Cell and Molecular Biology Study Section,,3,345375,
7754395,R01,HL,5,,01/05/2010,12/31/2010,PA-07-070,5R01HL088643-02,,NHLBI:372571;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WEISER-EVANS, MARY CM;",1920745;,5R01HL088643,01/15/2009,12/31/2012,"1-Phosphatidylinositol 3-Kinase; ATF; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Actins; Affect; Agonist; Alleles; Allelomorphs; Angioplasty; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Arterial Injury; Arterial Intimas; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attenuated; Autocrine Systems; Automobile Driving; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); BZS; Biological Function; Biological Process; Blood Vessels; Blood monocyte; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; CD11b; CD34; CD34 gene; CR3A; Cardiac Diseases; Cardiac Disorders; Cause of Death; Cell Communication and Signaling; Cell Function; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Process; Cell Proliferation; Cell Signaling; Cell Wall; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Migration; Cellular Physiology; Cellular Process; Cellular Proliferation; Chemoattractants; Chemotactic Factors; Chemotaxins; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cytokines, Chemotactic; DNA Recombination; DNA recombination (naturally occurring); Data; Dephosphorylation; Development; Differentiation Factor, B-Cell; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drivings, Automobile; Dysfunction; Embryo Development; Embryogenesis; Embryonic Development; Event; Exhibits; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family; Functional disorder; GFAC; Generalized Growth; Genes, LacZ; Genetic Recombination; Germ Layers; Grafting, Bone Marrow; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HPCA1; HPGF; Hand; Heart Diseases; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; Hybridoma Growth Factor; Hyperplasia; Hyperplastic; IFN-beta 2; IFNB2; IL-6; IL6 Protein; ITGAM; ITGAM gene; In Vitro; Inflammatory; Inflammatory Response; Injury; Intercrines; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intervention; Intervention Strategies; Intimas, Arterial; Intracellular Communication and Signaling; Knockout Mice; Label; LacZ; LacZ Genes; Lead; Leiomyocyte; Lesion; Link; Lipids; MAC-1; MAC1A; MGI-2; MHAM; MMAC1; MMAC1 protein; MO1A; Mammals, Mice; Maps; Marrow Transplantation; Marrow monocyte; Medial; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Modeling; Molecular; Mother Cells; Motility; Motility, Cellular; Murine; Mus; Mutant Strains Mice; Myeloid Differentiation-Inducing Protein; Myocytes, Smooth Muscle; Nuclear Receptors; Null Mouse; PDGF; PI-3 Kinase; PI-3K; PI3-Kinase; PPAR; PTEN; PTEN gene; PTEN protein; PTEN1; Paracrine Communication; Paracrine Signaling; Pathogenesis; Pathway interactions; Pb element; Peroxisome Proliferator-Activated Receptors; Phenotype; Phosphatase and Tensin Homolog; Phosphatases; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Physiologic; Physiological; Physiopathology; Plasmacytoma Growth Factor; Platelet-Derived Growth Factor; Procedures; Process; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Protein Dephosphorylation; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; PtdIns 3-Kinase; Publishing; RAFT1 protein, human; RAPT1 protein, human; Rapamycin Target Protein; Recombination; Recombination, Genetic; Recruitment Activity; Regulation; Relative; Relative (related person); Research Design; Reticuloendothelial System, Bone Marrow; Role; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Societies; Specificity; Staging; Stem cells; Stents; Study Type; Subcellular Process; System; System, LOINC Axis 4; Techniques; Technology; Testing; Tissue Growth; Transplantation; Tumor Suppressor Proteins; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular remodeling; Work; activating transcription factor; atheromatosis; atherosclerotic vascular disease; autocrine; base; biological signal transduction; cancer progression; cell growth; cell motility; chemoattractant cytokine; chemokine; clinical relevance; clinically relevant; complement chemotactic factor; cytokine; driving; heart disorder; heavy metal Pb; heavy metal lead; human FRAP1 protein; in vivo; inhibitor; inhibitor/antagonist; injured; injury response; interferon beta 2; interventional strategy; intraluminal angioplasty; mTOR; migration; monocyte; mouse mutant; mutated in multiple advanced cancers 1 protein; neointima formation; neointimal thickening; neoplasm progression; neoplastic progression; novel; ontogeny; paracrine; pathophysiology; pathway; phosphatase and tensin homologue on chromosome ten; post intervention; progenitor; programs; protective effect; public health relevance; rapamycin and FKBP12 target 1 protein, human; recruit; response; response to injury; restenosis; restoration; social role; study design; transcription factor; transplant; tumor progression; tumor suppressor; vascular",Role of PTEN in Vascular Lesion Formation," PROJECT NARRATIVE Complications of heart disease remain the leading cause of death in Western societies. While angioplasty/stent deployment and graft transplantations have been widely used for the treatment of atherosclerosis, a significant proportion of these procedures fail due to post-procedure restenosis, characterized by significant cell growth and inflammatory responses that lead to vessel blockage. Therefore, a great deal of effort has gone into defining the underlying mechanisms regulating these processes to reduce post-intervention vascular occlusion. Our studies are designed to test the role and mechanisms of action of a protein, PTEN, expressed by vascular cells in actively blocking the expression of a family of chemokines that otherwise promote vascular cell growth and an inflammatory response following vascular interventions.",88643,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,2,372571,
7761677,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL089012-03,,NHLBI:361125;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LOMA LINDA,UNITED STATES,PHYSIOLOGY,41,009656273,US,CA,92350,LOMA LINDA UNIVERSITY,"ZHANG, LUBO ;",1905562;,5R01HL089012,02/01/2008,01/31/2013,"Actins; Animal Welfare; Animals; Arteries; Attenuated; Bibliography; Biological Models; Blood Circulation; Blood Vessels; Blood flow; Bloodstream; Cardiovascular Diseases; Circulation; Circulation, Uteroplacental; Clinical; Corpus Luteum Hormone; Country; Critiques; Data; Delta4-pregnene-3,20-dione; Development; Ecological impact; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Environmental Impact; Equipment; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethics Committees, Research; Gene Expression; Genomics; Gestation; Goals; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Isoenzymes; Isozymes; Mediating; Model System; Models, Biologic; Mononitrogen Monoxide; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Pathway interactions; Pattern; Physiologic; Physiological; Pregn-4-ene-3,20-dione; Pregnancy; Pregnenedione; Pressure; Pressure- physical agent; Principal Investigator; Progesterone; Programs (PT); Programs [Publication Type]; Regulation; Research; Research Ethics Committees; Research Resources; Resistance; Resources; Role; Signal Pathway; Suggestion; Testing; Therapeutic Estrogen; Therapeutic Progesterone; Therapeutic Steroid Hormone; Uteroplacental Circulation; Vertebrate Animals; Vertebrates; abstracting; base; cardiovascular disorder; endothelial cell derived relaxing factor; expectation; expiration; fetal; human subject; in vivo; insight; novel; pathway; polymerization; pregnant; pressure; programs; resistant; social role; steroid hormone; tissue culture; vascular; vertebrata",Steroid Hormones and Uterine Vascular Adaptation to Pregnancy,,89012,ZRG1,Special Emphasis Panel,,3,361125,
7759606,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL089514-02,,NHLBI:365875;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,ANESTHESIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"STOWE, DAVID F;",2088168;,5R01HL089514,02/01/2009,12/31/2012,"2 Dimensional Gel Electrophoresis; Active Oxygen; Agonist; Anions; Apoptosis; Apoptosis Pathway; Atrial; Auricle of Heart; Autoregulation; Bioenergetic; Bioenergetics; Blotting, Western; Body Tissues; Cardiac; Cardiac Atrium; Cardiac Myocytes; Cardiocyte; Cavia; Cell Death, Programmed; Cell Protection; Cells; Cellular injury; Characteristics; Charge; Chromatography, Gas-Liquid-Mass Spectrometry; Complement; Complement Proteins; Complex; Consumption; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coupled; Cytoprotection; Data; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; EC 2.7; Electron Transport; Electrons; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Event; Exposure to; Feedback; Figs; Figs - dietary; GC MS; GCMS; Generations; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Guinea Pigs; H(+) Pump; H2O2; Hand; Heart; Heart Atrium; Heart myocyte; Homeostasis; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Hydroperoxide; In Situ; Infarction; Inner mitochondrial membrane; Ion Channels, Potassium; Ischemia; Ischemia-Reperfusion Injury; K channel; Kinases; Lead; Link; Lipid Bilayers; MALD-MS; MALDI; MALDI-MS; Mammals, Guinea Pigs; Mass Fragmentographies; Mass Fragmentography; Mass Spectrum; Mass Spectrum Analysis; Measures; Mechanics; Mediating; Medication; Membrane; Membrane Potentials; Memory; Metabolic; Methods and Techniques; Methods, Other; Mitochondria; Mitochondrial Matrix; Modeling; Molecular; Muscle Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle Cells, Mature; Muscle, Smooth, Vascular; Myocytes; Myocytes, Cardiac; NADH; Necrosis; Necrotic; Negative Beta Particle; Negatrons; Oxidation-Reduction; Oxygen Radicals; Pathway interactions; Patients; Pb element; Peptides; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiologic pulse; Physiological Homeostasis; Play; Potassium Channel; Pro-Oxidants; Proteins; Proton Pump; Public Health; Pulse; Reaction; Reactive Oxygen Species; Redox; Regulation; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Research; Respiration; Respiratory Chain; Resting Potentials; Role; Scheme; Source; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrometry, Mass-Gas Chromatography; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spectrum Analysis, Mass-Gas Chromatography; Stimulus; Superoxide Anion; Superoxide Radical; Superoxides; Swelling; Techniques; Testing; Tissues; Transmembrane Potentials; Transphosphorylases; V (voltage); Western Blotting; Western Blottings; Western Immunoblotting; application in practice; atrium; cardiomyocyte; catalase; cell damage; cell injury; cell type; conditioning; drug/agent; electron transfer; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; heavy metal Pb; heavy metal lead; improved; improved functioning; indexing; infarct; inhibitor; inhibitor/antagonist; ion trap mass spectrometry; lipid bilayer membrane; mass fragmentometry; matrix assisted laser desorption ionization; membrane structure; mimetics; mitochondrial; new approaches; novel approaches; novel strategies; novel strategy; oxidation reduction reaction; pathway; practical application; preconditioning; protective effect; protein blotting; public health medicine (field); public health relevance; reperfusion; respiratory; respiratory mechanism; skills; social role; tool; voltage",Mitochondrial Ca-sensitive K channel-induced superoxide and cardiac protection," Project Narrative Importance to Public Health: These studies will result in a better understanding of the regulation of mitochondrial bioenergetic function by Ca2+, K+, and ROS, and selection of the mitochondrion as a target for pharmacologic manipulation. This research should lead to the practical application of mitochondrial-targeted drugs to prophylactically treat patients with coronary artery disease using novel approaches.",89514,SAT,"Surgery, Anesthesiology and Trauma Study Section",,2,365875,
7758214,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL089742-02,,NHLBI:367000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,ANATOMY/CELL BIOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"GRAY, PAUL ;",8731318;,5R01HL089742,02/01/2009,01/31/2014,"21+ years old; Adult; Affect; Age; Allatostatin Receptor protein, Drosophila; AlstR protein, Drosophila; Anatomic; Anatomical Sciences; Anatomy; Animal Genetics; Apnea; Apnea, Sleep; Aspiration, Respiratory; Atlases; Behavior; Behavioral; Birth; Brain; Brain Stem; Brainstem; Breathing; Cell/Tissue, Immunohistochemistry; Characteristics; Cot Death; Crib Death; Cyclic Somatostatin; DAR-1 protein, Drosophila; Data; Development; Diagnosis; Disease; Disorder; Drosophila allatostatin receptor; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Exercise; Exercise, Physical; Fire - disasters; Fires; Gene Expression; Generations; Genes; Genetic; Genetic Identity; Genetic analyses; Genetics, in situ Hybridization; Genome; Glutamates; Goals; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; Health; Heterogeneity; Heterogeneity, Population; Human; Human, Adult; Human, General; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; In Vitro; Infant; Inhalation; Inhaling; Inspiration, Respiratory; L-Glutamate; Label; Lesion; Life; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Modeling; Molecular Genetic; Molecular Genetics; Murine; Mus; NK-1 Receptors; NK1R; NKIR; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Opioid; Organism; Output; Parturition; Parvalbumins; Pattern; Peptides; Phenotype; Physiologic; Physiological; Population; Population Group; Population Heterogeneity; Property; Property, LOINC Axis 2; Receptor Protein; Receptors, Neurokinin-1; Receptors, Somatotropin Release Inhibiting Hormone; Reporter; Resolution; Respiration; Role; SIDS; SP-P Receptors; SRIH; SRIH Receptors; SRIH-14; Science of Anatomy; Sleep Apnea Syndromes; Sleep Hypopnea; Sleep-Disordered Breathing; Slice; Somatostatin; Somatostatin Receptor; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; Speech; Substance P Receptor; Sudden Infant Death; Sudden Unexpected Death of Infant; Sudden Unexpected Infant Death; Sudden infant death syndrome; TAC1R; TACR1; TACR1 gene; Tachykinin Receptor 1; Target Populations; Testing; Thick; Thickness; Time; Toxin; Transgenic Animals; Transgenic Mice; Transgenic Model; Transgenic Organisms; Work; adult human (21+); allatostatin receptor, Drosophila; anatomy; base; developmental genetics; digital; disease/disorder; diverse populations; experiment; experimental research; experimental study; flexibility; genetic analysis; growth hormone release inhibiting factor; heterogeneous population; in situ Hybridization Staining Method; inspiration; living system; meetings; molecular marker; neonate; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal excitability; neuronal loss; novel; preBotzinger complex; premature; progenitor; public health relevance; receptor; recombinase; research study; respiratory; respiratory mechanism; selective expression; selectively expressed; social role; tool; transcription factor; transgenic",GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM, PROJECT NARRATIVE A number of disorders of human health are directly related to the brainstem networks underlying breathing such as apnea of prematurity and Sudden Infant Death Syndrome in infants or sleep apnea in adults. Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders.,89742,RIBT,Respiratory Integrative Biology and Translational Research Study Section,,2,367000,
7787435,R01,HL,5,,03/01/2010,02/28/2011,PA-07-070,5R01HL090712-02,,NHLBI:380000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,PEDIATRICS,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"RAMCHANDRAN, RAMANI ;",8836742;,5R01HL090712,03/16/2009,02/28/2013,"Address; Age related macular degeneration; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Appearance; Area; Assay; Autoregulation; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Serum; Blood Vessels; Blotting, Western; Brachydanio rerio; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Migration Assay; Cell Movement; Cell Signaling; Cell Surface Receptors; Cell surface; CellLine; Cells; Cellular Migration; Clinical; Complex; Cues; Cytoplasmic Domain; Cytoplasmic Tail; Danio rerio; Diabetic Retinopathy; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Targeting; Drug Targetings; Drugs; Endothelial Cells; Extravasation; Family; Figs; Figs - dietary; Filopodia; GTP; Gene Expression Inhibitor; Generalized Growth; Goals; Growth; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Homeostasis; Immigrations; Immune Precipitation; Immunoprecipitation; In Vitro; In-Migration; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Intracellular Signaling Proteins; Laboratories; Leakage; Ligands; Maculopathy, Age-Related; Mediating; Medication; Migration Assay; Molecular; Motility; Motility, Cellular; Oligonucleotides, Antisense; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; RNA, Small Interfering; Receptors, Cell Surface; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Signaling Proteins, Intracellular; Site; Small Interfering RNA; Spillage; Testing; Tissue Growth; Tumor Angiogenesis; Western Blotting; Western Blottings; Western Immunoblotting; Zebra Danio; Zebra Fish; Zebrafish; angiogenesis; axon growth cone guidance; axon guidance; base; biological signal transduction; cell motility; cultured cell line; disease/disorder; drug/agent; experiment; experimental research; experimental study; imaging modality; in vivo; interest; member; migration; ontogeny; protein blotting; protein complex; public health relevance; research study; response; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; selective expression; selectively expressed; senile macular disease; siRNA; therapeutic development; tumor; tumor growth; vascular; vascular bed",Roundabout4 signaling in endothelial cells," Tumor growth is angiogenesis dependant. We are interested in identifying vascular targets preferably cell surface molecules that are differentially expressed in tumor versus normal endothelial cells. This proposal studies one such target namely Robo4. Robo4 is highly expressed in tumor vessels. Tumor vessels are leaky, and the vascular bed often has a chaotic appearance. The first step in tumor angiogenesis is endothelial cell activation and directional migration of endothelial cells towards the tumor. Therefore, understanding the mechanisms of directional migration is critical for development of therapeutics that can selectively target tumor endothelial cells from taking this first step. This proposal will identify the mechanisms utilized by Robos in mediating directional migration in endothelial cells. We propose two aims to investigate mechanisms used by Robos to mediate directional migration. Accomplishing both aims will determine how Robo1 and Robo4 mechanistically assemble a signaling complex inside endothelial cells in response to Slit2 ligand, thereby co-ordinating directional migration of endothelial cells. This study will identify intracellular molecules common to the Robo1 and Robo4 signaling apparatus that serve as targets for drug design benefiting conditions associated with deregulated endothelial cell migration such as those associated with tumor growth.",90712,VCMB,Vascular Cell and Molecular Biology Study Section,,2,380000,
7762710,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL090804-02,,NHLBI:325000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PHILADELPHIA,UNITED STATES,PHARMACOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"BRAILOIU, EUGEN ;",8259170;,5R01HL090804,02/01/2009,01/31/2013,"Address; Agonist; Androstenedione Aromatase; Aquadiol; Aromatase; Aromatase Cytochrome P450; Blood Coagulation Factor IV; Blood Pressure; Blood Pressure Monitors; Bradycardia; Brain Stem; Brainstem; CYP 19; CYP19 Protein; CYPXIX; Ca++ element; Calcium; Cardiac; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Chronotropism, Cardiac; Chronotropisms, Cardiac; Clinical; Coagulation Factor IV; Common Rat Strains; Conjugated Equine Estrogens; Corpus Luteum Hormone; Cranial Nerve X; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); Delta4-pregnene-3,20-dione; Development; Dimenformon; Diogyn; Diogynets; Equine Estrogens, Conjugated; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Nuclear Receptor; Estrogen Receptors; Estrogen Synthase; Estrogen Synthetase; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethyl Carbamate; Ethyl Urethan; Factor IV; Goals; Heart; Heart Rate; Hormone Replacement Rx; Hormone replacement therapy; Hypothalamic structure; Hypothalamus; IHC; IV drip; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Intracellular Communication and Signaling; Intravenous Drip; Intravenous Infusion; Knowledge; Label; Link; Mammals, Rats; Measurable; Measurement; Mediating; Membrane; Methods and Techniques; Methods, Other; Microinjections; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nuclear Receptors; Nucleus Ambiguus; Organ System, Cardiovascular; Ovocyclin; Ovocylin; P450AROM; Pathway interactions; Pneumogastric Nerve; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Pre-Menopause; Pre-menopausal Period; Pregn-4-ene-3,20-dione; Pregnenedione; Premenopausal; Premenopausal Period; Premenopause; Pressure; Pressure- physical agent; Progesterone; Progynon; Property; Property, LOINC Axis 2; Rat; Rattus; Receptor, Estrogen Nuclear; Regulation; Relative; Relative (related person); Role; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Source; Sphygmomanometers, Continuous; Staining method; Stainings; Stains; Structure of nucleus ambiguus; Synapses; Synaptic; Techniques; Tenth Cranial Nerve; Testing; Therapeutic; Therapeutic Agents; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Progesterone; Urethane; Vagus Nerve; Vagus nerve structure; Vascular, Heart; Woman; biological signal transduction; calcium flux; calcium mobilization; carbamic acid, ethyl ester; cardiovascular disorder; cardiovascular function; cholinergic neuron; circulatory system; design; designing; drip infusion; experiment; experimental research; experimental study; extracellular; hypothalamic; imaging; immunocytochemistry; in vivo; insight; interdisciplinary approach; intravenous administration; membrane structure; neural circuit; neural circuitry; neuronal; novel; nucleus ambiguus; patch clamp; pathway; post-menopausal; postmenopausal; pre-menopausal; pressure; protective effect; public health relevance; release of sequestered calcium ion into cytoplasm; research study; response; social role; vein infusion",Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons, NARRATIVE We will study the role of a new estrogen receptor in the central control of cardiovascular function. A better understanding of the mechanisms of action of estrogen is critical for the development of new treatments for cardiovascular disease.,90804,HM,Hypertension and Microcirculation Study Section,,2,325000,
7759512,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL090823-03,,NHLBI:328500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,PATHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"HOMEISTER, JONATHON ;",8539421;,5R01HL090823,02/01/2008,01/31/2013,"3-fucosyltransferase; APOE [{C0003595}]; Adhesion Molecule; Adhesions; Adhesives; Alpha-Fucosyltransferases; Animal Welfare; Apo-E; ApoE; Apolipoprotein E; Arterial Fatty Streak; Assay; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attention; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood leukocyte; Blood monocyte; Breeding; CD62P Antigens; Cause of Death; Cell Adhesion; Cell Adhesion Molecules; Cellular Adhesion; Country; Dependence; Development; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Disease; Disorder; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fucosyltransferase; GMP-140; Gene Targeting; Gene Transfer Techniques; Genotype; Goals; Histology; IACUC; IRBs; Impact, Environmental; In Vitro; Inbred Strain; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; LECAM-3; Lesion; Leukocytes; Lewis-negative alpha-3-fucosyltransferase; Ligands; Lipoprotein LDL Receptors; Low Density Lipoprotein Receptor; Mammals, Mice; Marrow leukocyte; Marrow monocyte; Measures; Mediating; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Names; P-Selectin; Pathology; Platelet alpha-Granule Membrane Protein; Prevention strategy; Preventive strategy; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Reagent; Receptors, LDL; Recruitment Activity; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Leukocytes; Role; Selectins; Staining method; Stainings; Stains; Streaks, Arterial Fatty; Targetings, Gene; Techniques; Testing; Therapeutic; Transgenesis; United States; Vertebrate Animals; Vertebrates; White Blood Cells; White Cell; abstracting; atherogenesis; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; cell adhesion protein; disease/disorder; experiment; experimental research; experimental study; expiration; galactoside 3-fucosyltransferase; human subject; improved; in vivo; macrophage; monocyte; mouse model; novel; peripheral blood; programs; reconstitute; reconstitution; recruit; research study; shear stress; social role; trafficking; vertebrata; vulnerable plaque; white blood cell; white blood corpuscle",Selectin-dependent lineage-specific leukocyte recruitment in atherogenesis.,,90823,AICS,Atherosclerosis and Inflammation of the Cardiovascular System Study Section,,3,328500,
7760158,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL090851-03,,NHLBI:387500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"SORESCU, DAN ;",7846848;,5R01HL090851,02/01/2008,01/31/2013,"ANG-(1-8)Octapeptide; Acetylation; Actins; Active Oxygen; Admission; Admission activity; Affect; AngII; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensin-Forming Enzyme; Angiotensinogenase; Animal growth regulators, transforming growth factors; Antiheparin Factor; Binding; Binding (Molecular Function); Blood Platelet Factor IV; Blood Pressure, High; Blood platelet factor 4; CTGF; Cardiac; Cardiac Failure Congestive; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell-Extracellular Matrix; Chemokine (C-X-C motif) Ligand 4; Chronic; Cicatrix; Cold-Insoluble Globulins; Collagen; Complex; Congestive Heart Failure; Cysteine; Cytosolic Protein Tyrosine Phosphastase; Data; Development; EC 2.7; ECM; Enzymes; Extracellular Matrix; FN1; FNZ; FOXO3A; FOXO3A gene; Factor 4; Fibroblasts; Fibronectin 1; Fibronectins; Fibrosis; Free Radical Formation; GTP Phosphohydrolases; GTPases; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; HOSP; HTRPY; Half-Cystine; Heart; Heart Decompensation; Heart Failure, Congestive; Heart Hypertrophy; Heart failure; Heart myocyte; Heparin Neutralizing Protein; Homeo Boxes; Homeobox; Hospitalization; Human; Human, General; Hypertension; Hypertrophy; IGF-binding protein-related protein-2; IGFBP-8; IGFBP-rP2; INFLM; In Vitro; Inflammation; Infusion; Infusion procedures; Isoforms; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Kinases; Knock-out; Knockout; L-Cysteine; LETS Proteins; Laboratories; Large External Transformation-Sensitive Protein; Link; Location; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Molecular Interaction; Molecular Weight; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Mothers; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Nuclear; Nuclear Translocation; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Organ System, Cardiovascular; Oxidases; Oxidation-Reduction; Oxygen Radicals; PTPase; Pathway interactions; Patients; Pattern; Phenotype; Phosphotransferases; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Platelet Factor 4; Play; Pressure; Pressure- physical agent; Pro-Oxidants; Process; Production; Protein Isoforms; Protein Tyrosine Phosphatase; Proteins; Publishing; Reactive Oxygen Species; Recombinant Platelet Factor 4; Redox; Renin; Role; Scars; Small G-Proteins; Small GTPases; Small Inducible Cytokine B4; Small Inducible Cytokine Subfamily B, Member 4; Source; Testing; Transforming Growth Factors; Transphosphorylases; Tumor Growth Factors; Tyrosine Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; alpha 2-Surface Binding Glycoprotein; angiogenesis; base; c jun; c-jun Gene; cardiac failure; cardiac hypertrophy; cardiac infarct; cardiac muscle; cardiomyocyte; circulatory system; connective tissue growth factor; coronary attack; coronary infarct; coronary infarction; cytokine; fisp12 protein; gamma-Thromboglobulin; gene product; guanosinetriphosphatase; heart attack; heart cell; heart infarct; heart infarction; heart muscle; hyperpiesia; hyperpiesis; hypertensive disease; in vivo; inhibitor; inhibitor/antagonist; insulin-like growth factor binding protein 8; novel; overexpression; oxidation reduction reaction; pathway; platelet factor IV; pressure; prevent; preventing; protein expression; protein tyrosine phosphate phosphohydrolase; response; rho; social role; transcription factor",Nox4 and Cardiac Fibrosis,"Congestive heart failure is a major cause of hospitalization (over 500,000 admissions  per year) and affect over 5 million patients in US. In the current application we will study  the mechanism of development and progression of heart failure. Heart failure has two  major causes: one is due to weakness of heart muscle caused by prior heart attacks or  high blood pressure in which the heart muscle is replaced with scar and the other due to  inappropriate accumulation of scar in the heart muscle which creates heart stiffness and  increased pressures inside the heart. In our proposal we plan to identify the mechanisms  by which the excessive scar forms as a consequence of increased free radicals  formation in the heart. We have currently identified a key enzyme called Nox4, which is  present in heart cells and is required for scar formation during the development of heart  failure.",90851,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,3,387500,
7749545,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL090948-04,,NHLBI:371486;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AUGUSTA,UNITED STATES,PHYSIOLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"STERN, JAVIER E;",6801338;,5R01HL090948,01/15/2008,12/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Aminalon; Aminalone; Animals; Arts; Astrocytes; Astrocytus; Astroglia; Blood Plasma; Blood Pressure, High; Brain; Butanoic acid, 4-amino-; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Chronic; Cleaved cell; Common Rat Strains; Communication; Complex; Consensus; Disease; Disorder; Dysfunction; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Equilibrium; Excitatory Amino Acids; Forecast of outcome; Functional disorder; GABA; Glutamate Receptor; Glutamates; Goals; Health; Heart failure; Hormonal; Hypertension; Hypothalamic structure; Hypothalamus; Intracellular Communication and Signaling; Investigators; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Isoforms; Kidney; L-Glutamate; Laboratories; Lead; Mammals, Rats; Mediating; Methods and Techniques; Methods, Other; Modeling; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Myocardial Ischemia; Names; Nature; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Neurotransmitters; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; Output; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathway interactions; Patients; Pb element; Physiopathology; Plasma; Play; Principal Investigator; Probability; Production; Prognosis; Programs (PT); Programs [Publication Type]; Protein Isoforms; Public Health; Rat; Rattus; Receptor Protein; Reflex; Reflex action; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Risk; Role; Secondary to; Series; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Source; Structure of paraventricular nucleus; Synapses; Synaptic; Synaptic Cleft; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Urinary System, Kidney; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Work; balance; balance function; biological signal transduction; cardiac failure; cardiovascular disorder; cardiovascular function; circulatory system; cleaved; conformation; conformational state; density; disease/disorder; endothelial cell derived relaxing factor; excitatory aminoacid; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; heart ischemia; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; hypothalamic; improved; innovate; innovation; innovative; intercellular communication; interdisciplinary approach; multidisciplinary; myocardial ischemia/hypoxia; myocardium ischemia; neuronal; neuronal circuitry; neuronal excitability; novel; outcome forecast; paraventricular nucleus; pathophysiology; pathway; postsynaptic; presynaptic; prevent; preventing; programs; public health medicine (field); receptor; renal; research study; single molecule; social role; synapse function; synaptic function",Altered CNS intercellular signaling mechanisms in cardiovascular disease,,90948,HM,Hypertension and Microcirculation Study Section,,4,371486,
7759170,R01,HL,5,,02/01/2010,01/31/2011,PA-07-138,5R01HL090975-02,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"HONG, SUZI ;",8862530;,5R01HL090975,02/01/2009,01/31/2014,"21+ years old; ACRP30 protein; ATGN; Active Follow-up; Adhesion Molecule; Adult; Affect; American; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antigens; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Apoplexy; Applications Grants; Articulation; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Attention; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Biological; Biology; Blood Neutrophil; Blood Plasma; Blood Polymorphonuclear Neutrophil; Blood Pressure; Blood Pressure, High; Blood Segmented Neutrophil; Blood Vessels; Blood leukocyte; Blood monocyte; Body fat; Boxing; Brachial Artery; CD11b; CR3A; Caliber; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Adhesion Molecules; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Communities; Conditioning Therapy; Control Groups; DEXA; DIF; Data; Detection; Development; Diameter; Differentiation Factor, B-Cell; Drugs; Dysfunction; EDN1; ET-1; ET-1 (Endothelin-1); Endothelial Cells; Endothelin Type 1; Endothelin-1; Endothelium, Vascular; Epidemiology; Evaluation; Event; Exercise; Exercise, Physical; Functional disorder; Future; Grant Proposals; Grants, Applications; HPGF; Health; Hepatocyte-Stimulating Factor; Heterophil Granulocyte; High Prevalence; Human, Adult; Hybridoma Growth Factor; Hypertension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; ITGAM; ITGAM gene; Immune; Immune Cell Activation; Immune system; Individual; Inflammation; Inflammatory; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Investigation; Joints; Laboratories; Lead; Leptin; Leukocytes; Life Style Modification; Light; Link; Literature; Longitudinal Studies; MAC-1; MAC1A; MGI-2; MO1A; Marrow Neutrophil; Marrow leukocyte; Marrow monocyte; Mediating; Medication; Modeling; Myeloid Differentiation-Inducing Protein; Names; Nature; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Neutrophil Activation; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Obesity; Organ System, Cardiovascular; Oxidative Burst; PBMC; Pathology; Pathway interactions; Pb element; Peripheral Blood Mononuclear Cell; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Physiopathology; Plasma; Plasmacytoma Growth Factor; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population; Population Study; Prevention; Process; Production; Public Health; Reporting; Respiratory Burst; Rest; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Serum, Plasma; Risk; Risk Factors; Role; Serum, Plasma; Spottings; Staging; Stress; Stress Tests; Stroke; Structure of brachial artery; T-Cells; T-Lymphocyte; TNF; TNF A; TNF gene; TNFSF2; Thymus-Dependent Lymphocytes; Trier Social Stress Test; Tumor Necrosis Factor Gene; Vascular Accident, Brain; Vascular Endothelium; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Weight; White Blood Cells; White Cell; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adiposity; adult human (21+); apM-1 protein; apM1 (adipose-specific) protein; atheromatosis; atherosclerotic vascular disease; base; behavior intervention; behavioral intervention; body system, allergic/immunologic; brachial artery; brain attack; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cell adhesion protein; cerebral vascular accident; circulatory system; corpulence; corpulency; corpulentia; cytokine; drug/agent; follow-up; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; immunogen; inflammatory marker; interferon beta 2; leukocyte oxidative burst; long-term study; monocyte; neutrophil; normotensive; novel; ob/ob mouse; obese; obese people; obese person; obese population; obesity prevention; organ system, allergic/immunologic; pathophysiology; pathway; psychologic; psychological; public health medicine (field); public health relevance; resistin; respiratory burst (leukocyte); response; social role; stressor; stroke; thymus derived lymphocyte; vascular; vascular endothelial dysfunction; vascular inflammation; waist circumference; white blood cell; white blood corpuscle",Role of obesity on vascular inflammation and immune cell activation in prehyperte," PROJECT NARRATIVE Prehypertension is recognized as a risk factor for cardiovascular disease (CVD), but little is known of the vascular biology of this ""prelude"" to hypertension. We propose to investigate the degree to which adiposity contributes to vascular inflammation that may underlie future development of hypertension and CVD in prehypertensive individuals. This study of underlying vascular pathology in obesity-related prehypertension will have a significant public health impact by providing the evidence for the need for behavioral modifications to reduce obesity for the prevention of hypertension and by providing a mechanistic understanding of the contributions of obesity to immune and vascular biology (""bench-to-community, beyond bedside"").",90975,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,2,386250,
7760147,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL091157-03,,NHLBI:377650;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"KWONG, RAYMOND Y;",7853381;,5R01HL091157,02/05/2008,01/31/2013,"Acute myocardial infarct; Acute myocardial infarction; Affect; Age; Animal Welfare; Anisotropy; Arrhythmia; Bibliography; Body Tissues; Cardiac; Cardiac Arrhythmia; Cardiac Death; Cardiac infarction; Cardioversion; Cell Communication and Signaling; Cell Signaling; Clinical; Clinical Trials Design; Complication; Control Groups; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Country; Criteria, Selection; Death, Cardiac; Death, Sudden, Cardiac; Defibrillation, Electric; Defibrillators, Implantable; Digital Signal Processing; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Ecological impact; Electric Countershock; Electroversion, Cardiac; Electroversions, Cardiac; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Exhibits; Fatty Acids, Omega-3; Favorable Clinical Outcome; Fibrosis; Forecast of outcome; Generations; Healed; Heart Arrhythmias; Heart Muscle tissue; Heterogeneity; IACUC; IRBs; Impact, Environmental; Implantable Cardioverter-Defibrillators; Implantable Defibrillators; Incidence; Infarction; Institutional Animal Care and Use Committee; Institutional Review Boards; Intake; International; Intracellular Communication and Signaling; LVEF; Left Ventricular Ejection Fraction; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant; Malignant - descriptor; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane; Methods and Techniques; Methods, Other; Mortality; Mortality Vital Statistics; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Muscle Cells; Muscle Cells, Mature; Muscle, Cardiac; Muscle, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial tissue; Myocardium; Myocytes; Myristica fragrans; NMR Imaging; NMR Tomography; Names; Nuclear Magnetic Resonance Imaging; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Oral; PBO; Patients; Placebo Control; Placebos; Principal Investigator; Prognosis; Programs (PT); Programs [Publication Type]; Publishing; Randomized; Randomized Clinical Trials; Reporting; Research; Research Ethics Committees; Research Resources; Resources; Risk; Secondary to; Selection Criteria; Sham Treatment; Side; Signal Transduction; Signal Transduction Systems; Signaling; Supplementation; Tachycardia, Ventricular; Techniques; Testing; Therapeutic; Tissues; Translating; Translatings; Trials, Randomized Clinical; Ventricular; Ventricular Arrhythmia; Ventricular Function; Ventricular Tachycardia; Vertebrate Animals; Vertebrates; Zeugmatography; abstracting; base; biological signal transduction; cardiac infarct; cardiac muscle; cohort; coronary attack; coronary infarct; coronary infarction; defibrillation; design; designing; electric countershock heart resuscitation; expiration; healing; heart attack; heart infarct; heart infarction; heart muscle; high risk; human subject; improved; infarct; language translation; mace; membrane structure; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; n-3 Fatty Acids; novel; omega-3; outcome forecast; pre-clinical; preclinical; prognostic; programs; protective effect; randomisation; randomization; randomized placebo controlled study; randomized placebo controlled trial; randomly assigned; sham therapy; tool; vertebrata",Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI,,91157,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,3,377650,
7753653,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL091244-03,,NHLBI:717606;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"SISCOVICK, DAVID ;",1875274;,5R01HL091244,03/07/2008,12/31/2012,"Accounting; Acyl CoA; Acyl Coenzyme A; Acylation; Address; Affect; African American; Afro American; Afroamerican; Alleles; Allelomorphs; American; Asystole; Attention; Black Populations; Black or African American; Blood; Blood Sample; Blood erythrocyte; Blood normocyte; Blood specimen; Candidate Disease Gene; Candidate Gene; Cardiac; Cardiac Arrest; Cardiac Diseases; Cardiac Disorders; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Causality; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Cessation of life; Clinical; Clinical Data; CoA; Coenzyme A; Cohort Studies; Collection; Communities; Complex; Concurrent Studies; Coronary Disease; Coronary heart disease; County; Cytoplasmic Membrane; DNA; Data; Death; Deoxyribonucleic Acid; Development; Dietary intake; Disease; Disorder; Eicosanoid Production; Eicosanoids; Environmental Factor; Environmental Risk Factor; Erythrocytes; Erythrocytic; Essential Fatty Acids; Etiology; European; Fatty Acid Metabolism Pathway; Fatty Acids; Fatty Acids, Essential; Fatty Acids, Polyunsaturated; Fatty Acyl CoA; Gene variant; Generations; Genes; Genetic; Genetic Diversity; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetics, Human; Genomics; Goals; HOSP; Health; Heart Arrest; Heart Diseases; Hospitals; Human; Human Genetics; Human, General; Individual; Inherited Predisposition; Inherited Susceptibility; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Ions; Knowledge; Label; Life; Long-Chain Acyl CoA; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Mediating; Medicine; Membrane; Membrane Channels; Metabolic Pathway; Methodology, Research; Methods; Modeling; Molecular Genetic; Molecular Genetics; Mortality; Mortality Vital Statistics; Nuclear; Nuclear Receptors; Organ System, Cardiovascular; Paramedic; Paramedical Personnel; Pathway interactions; Patients; Pattern; Plasma Membrane; Polyunsaturated Fatty Acids; Population; Population Study; Position; Positioning Attribute; Predisposition; Prevention; Production; Public Health; Receptor Protein; Receptor Signaling; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Research; Research Design; Research Methodology; Research Methods; Research Resources; Research Specimen; Resources; Reticuloendothelial System, Blood; Reticuloendothelial System, Erythrocytes; Risk; Science of Medicine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Stratification; Study Type; Susceptibility; Trans Fatty Acids; United States; Variant; Variation; Variation (Genetics); Vascular, Heart; Ventricular Arrhythmia; Ventricular Fibrillation; Washington; Work; allelic variant; biological signal transduction; black American; blood corpuscles; cardiac electrical activity; cardiovascular disorder; circulatory system; coronary disorder; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environment effect on gene; environmental risk; family influence; fatty acid metabolism; fatty acid oxidation; gene environment interaction; gene interaction; genetic epidemiology; genetic etiology; genetic mechanism of disease; genetic vulnerability; heart disorder; heart electrical activity; high risk; insight; membrane structure; novel; pathway; plasmalemma; polyunsaturated fatty acid; population based; public health medicine (field); receptor; repository; study design; uptake",HUMAN GENETIC VARIATION IN FATTY ACID METABOLISM AND SUDDEN CARDIAC ARREST,,91244,CICS,Clinical and Integrative Cardiovascular Sciences Study Section,,3,717606,
7760965,R01,HL,5,,02/01/2010,01/31/2011,HL-07-009,5R01HL091754-03,,NHLBI:367822;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SALT LAKE CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"WEYRICH, ANDREW SCOTT;",1916182;,5R01HL091754,02/01/2008,01/31/2012,"Acute Pulmonary Injury; Animal Welfare; Basic Research; Basic Science; Bibliography; Bizzozero's corpuscle/cell; Blood Coagulation Factor III; Blood Platelets; Blood leukocyte; Blood megakaryocyte; CD142 Antigens; Cell Communication and Signaling; Cell Signaling; Clinical; Clotting; Coagulation; Coagulation Factor III; Coagulation Process; Coagulin; Code; Coding System; Country; Data; Deetjeen's body; Development; Dysfunction; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Factor III; Functional disorder; Gene Expression Profile; Glomerular Procoagulant Activity; Hayem's elementary corpuscle; IACUC; INFLM; IRBs; Impact, Environmental; Incidence; Inflammation; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukins; International; Intervening Sequences; Intracellular Communication and Signaling; Introns; Investigation; Knowledge; Leukocytes; Lung Injury, Acute; Marrow leukocyte; Marrow platelet; Megakaryocytes; Megalokaryocyte; Messenger RNA; Molecular; Mortality; Mortality Vital Statistics; Names; Nuclear; Pathologic; Patients; Pattern; Physiopathology; Platelets; Pre-mRNA; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Prothrombinase; RNA Splicing; RNA, Messenger; RNA, Messenger, Precursors; RNA, Messenger, Splicing; Research; Research Ethics Committees; Research Resources; Resources; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Platelets; Risk; Risk Factors; Role; Sepsis; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Splicing; Therapeutic Intervention; Thrombocytes; Thromboplastin; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Transcript; Translating; Translatings; Urothromboplastin; Vertebrate Animals; Vertebrates; White Blood Cells; White Cell; abstracting; acute lung injury; biological signal transduction; bloodstream infection; cytokine; disease severity; expiration; gene expression signature; gene product; human subject; insight; intervention therapy; language translation; mRNA; mRNA Precursor; novel; pathophysiology; premRNA; programs; response; social role; thrombocyte/platelet; transcriptome; unspecified interleukin; vertebrata; white blood cell; white blood corpuscle",Novel Activities of Platelets in Acute Lung Injury,,91754,ZHL1,Special Emphasis Panel,,3,367822,
7761670,R01,HL,5,,02/01/2010,01/31/2011,PAR-07-102,5R01HL091767-02,,NHLBI:353670;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MERCED,UNITED STATES,NONE,18,113645084,US,CA,95343,"UNIVERSITY OF CALIFORNIA, MERCED","ORTIZ, RUDY M;",7801728;,5R01HL091767,02/01/2009,01/31/2014,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one; 15-F(2t)-IsoP; 15-F(2t)-isoprostane; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 3-mononitrotyrosine; 3-nitrotyrosine; 4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; 8-F(2t)-isoprostane; 8-iso-PGF(2alpha); 8-iso-PGF2alpha; 8-isoprostaglandin F2alpha; 8-isoprostane; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; ACTH; ACTH (1-39); ANG-(1-8)Octapeptide; Aacidexam; Address; Adexone; Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Age; Age-Months; Aknichthol Dexa; Alba-Dex; Aldosterone; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anemul mono; AngII; Angiotensin II; Angiotensin Receptor; Angiotensin-(1-8) Octapeptide; Angiotensin-Forming Enzyme; Angiotensinogenase; Animals; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Antimicotico; Antioxidants; Apnea, Sleep; Aquapred; Auxiloson; Azona; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Baycuten; Baycuten N; Behavior; Body Tissues; Breeding; C-reactive protein; Cachectin; Cachectin-Tumor Necrosis Factor; California; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cetacort; Chronic; Constitution; Corson; Cort-Dome; Cortef; Cortenema; Corticotropin; Corticotropin (1-39); Cortidexason; Cortisol; Cortispray; Cortisumman; Cortril; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dehydration; Dekacort; Deltafluorene; Dermacort; Deronil; Desamethasone; Desameton; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Differentiation Factor, B-Cell; Dinormon; Diving; Drug Interactions; EC 2.5.1.18; Effectiveness; Eldecort; Electrolytes; Enzymes; Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-; Event; Exhibits; Experimental Water Deprivation; Fasting; Female; Film; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Food; Food Deprivation; Food deprivation (experimental); Fortecortin; GST; Gammacorten; Gases; Gender; Glucocorticoid Receptor; Glucocorticoids; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Alkyltransferase; Glutathione S-Aralkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Glutathione S-Transferase; Glutathione Transferase; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Goals; HPGF; Heme Transfer Protein; Hepatocyte-Stimulating Factor; Hexadecadrol; Hexadrol; Human; Human, General; Hybridoma Growth Factor; Hydrocortisone; Hydrocortone; Hydrogen Oxide; Hydrogen-peroxide[{..}]hydrogen-peroxide oxidoreductase; Hypoxia; Hypoxic; Hytone; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; IPO-B; Inflammation; Inflammatory; Inflammatory Response; Infusion; Infusion procedures; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Life; Ligandins; Lipid Peroxidation; Lokalison-F; Loverine; Lung diseases; MGI-2; MNSOD; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Methylfluorprednisolone; Mifegyne; Mifeprex; Mifepristone; Millicorten; Mirounga; Mitochondrial Superoxide Dismutase; Mitochondrial Superoxide Dismutase 2; Mn Superoxide Dismutase; Modeling; Mothers; Muscle; Muscle Tissue; Myeloid Differentiation-Inducing Protein; Mymethasone; Nitrates; Nitrites; Nurses; Nutracort; Ocasa; Orgadrone; Organ System; Organ System, Cardiovascular; Oxidative Stress; Oxygen Deficiency; Oxygen measurement, partial pressure, arterial; Partner in relationship; Personnel, Nursing; Physiologic; Physiological; Plasmacytoma Growth Factor; Predni-F; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Proctocort; Protein C; Proteins; Proteins, specific or class, C-reactive; Pulmonary Diseases; Pulmonary Disorder; RX[{..}]glutathione R-transferase; Receptor Signaling; Renin; Renin-Angiotensin System; Research; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; S-Hydroxyalkyl Glutathione Lyase; SOD2; SOD2 gene; SOD2 protein; SOD2 protein, human; Sea; Seals, Elephant; Seasons; Sleep; Sleep Apnea Syndromes; Sleep Hypopnea; Sleep-Disordered Breathing; Spersadex; Spersadox; Superoxide Dismutase 2; Surface; TNF-alpha; Therapeutic Glucocorticoid; Therapeutic Hydrocortisone; Therapeutic Intervention; Time; Tissues; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Universities; Vascular, Heart; Visumetazone; Water; Water Deprivation; Weaning; anti-oxidant; arterial pO2; auricularum; biomarker; body system; body water dehydration; catalase; circulatory system; deprived of food; design; designing; experience; fasted; fasts; fighting; gene product; glutathione aralkyltransferase; glutathione aryltransferase; glutathione peroxidase; human SOD2 protein; indexing; inflammatory marker; interferon beta 2; intervention therapy; isoprostaglandin F2alpha type-III; life history; lung disorder; male; mate; member; new therapeutic target; nitrosative stress; nitrotyrosine; novel; oxygen tension; prevent; preventing; public health relevance; pup; resistant; respiratory; response; seal",Mechanisms of Oxidative Stress and Inflammation during Prolonged Fasting and Slee,,91767,ZRG1,Special Emphasis Panel,,2,353670,
7754061,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL091905-02,,NHLBI:364968;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,FORT COLLINS,UNITED STATES,VETERINARY SCIENCES,04,785979618,US,CO,80523,COLORADO STATE UNIVERSITY-FORT COLLINS,"EARLEY, SCOTT ;",6558438;,5R01HL091905,01/01/2009,12/31/2013,"1,2-diacylglycerol; Acute; Address; Agonist; Apoplexy; Arteries; Arterioles; Blood Pressure; Blood Pressure, High; Blood Vessels; Blood flow; C protein; CBP protein (citrate-binding); Calcium Ion Signaling; Calcium Phospholipid-Dependent Protein Kinase; Calcium Signaling; Calcium-Activated Phospholipid-Dependent Kinase; Caliber; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; Cell membrane; CellLine; Cells; Cerebral Arteries; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chiro-Inositol; Cleaved cell; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Cytoplasmic Membrane; DAG; Development; Diacylglycerols; Diameter; Diglycerides; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Electrodes, Miniaturized; Electrophysiology; Electrophysiology (science); Event; Generations; Goals; Health; Human; Human, General; Hypertension; Image; Inositide Phospholipids; Inositol; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigation; Ion Channel Protein; Isoforms; Lecithinase C; Leiomyocyte; Length; Life; Man (Taxonomy); Man, Modern; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Potentials; Mesoinositol; Methods and Techniques; Methods, Other; Microcirculation; Microelectrodes; Microscopy, Video; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Proteins; Muscle Tissue; Muscle, Involuntary; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes; Myocytes, Smooth Muscle; Neurophysiology / Electrophysiology; Organ System, Cardiovascular; Outcome; PIP2; PKC; Pathology; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphatidyl Inositol; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphatidylinositols; Phosphoinositides; Phospholipase C; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physiologic; Physiological; Plasma Membrane; Pressure; Pressure- physical agent; Property; Property, LOINC Axis 2; Protein Isoforms; Protein Kinase C; Proteins; PtIns 4,5-P2; PtdIns; PtdIns(4,5)P2; PtdInsP2; RNA, Small Interfering; Receptor Protein; Regulation; Resting Potentials; Role; Sarcoplasmic Reticulum; Second Messenger Systems; Second Messengers; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Small Interfering RNA; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Stimulus; Stroke; Structure of arteriole; Structure of cerebral artery; Techniques; Technology; Testing; Transmembrane Potentials; Travel; V (voltage); Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular constriction (function); Vascular resistance; Vascular, Heart; Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasopressor Agents; Video Microscopy; Videomicrography; Videomicroscopy; arteriole; biological signal transduction; brain attack; cerebral artery; cerebral vascular accident; circulatory system; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; cleaved; constriction; cultured cell line; diacylglycerol; diglyceride; disease/disorder; drug discovery; experiment; experimental research; experimental study; gene product; hyperpiesia; hyperpiesis; hypertensive disease; imaging; improved; in vivo; lipophosphodiesterase I; membrane structure; novel; patch clamp; phosphatidylcholine cholinephosphohydrolase; phosphatidylinositol phosphate, PtdIns(4,5)P2; plasmalemma; pressure; prevent; preventing; public health relevance; receptor; research study; response; second messenger; siRNA; social role; stroke; trafficking; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; vascular; vasopressor; voltage",TRP Channel-Dependent Regulation of Arterial Tone," Project Narrative: Experiments described in this proposal will examine how TRPM4, an ion channel protein present in smooth muscle cells that line the walls of blood vessels, controls the diameter of small arteries and arterioles. This is important because these small blood vessels regulate blood flow and pressure, and impaired control of their diameter contributes to cardiovascular-related disease, such as hypertension, stroke, and coronary artery disease. The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases.",91905,VCMB,Vascular Cell and Molecular Biology Study Section,,2,364968,
7767014,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL092473-02,,NHLBI:358000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PALO ALTO,UNITED STATES,,14,624218814,US,CA,943040038,"PALO ALTO INSTITUTE FOR RES & EDU, INC.","AZHAR, SALMAN ;",1869144;,5R01HL092473,02/15/2009,01/31/2014,"21+ years old; 4,4'-(2,3 Dimethyl-1,4-butanediyl)bis(1,2-benzenediol); ACC1 enzyme; Abdominal obesity; Adult; Affect; Android fat distribution; Animals; Anti-atherogenic; Antiatherogenic; Apo-B; ApoB; Apolipoproteins B; Assay; Atherogenic Diet; Attenuated; Band Shift Mobility Assay; Bandshift Mobility Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood Glucose; Blood Plasma; Blood Pressure; Blood Pressure, High; Blood Sugar; Blotting, Western; Body Weight decreased; Cancers; Cannot achieve a pregnancy; Cardiovascular Diseases; Cell model; Cellular model; Central obesity; Centripetal obesity; Cholelithiasis; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical; Combined Modality Therapy; Common Rat Strains; Creosote Bush; D-Glucose; Developing Countries; Developing Nations; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet, Atherogenic; Difficulty conceiving; Dihydronorguaiaretic Acid; Drug Combinations; Drugs; Dyslipidemias; Electrophoretic Mobility Shift Assay; Enzymes; Epidemic; Event; FABP1; FABP1 gene; FABPL; Fat body with thin limbs; Fatty Acids; Fatty Acids, Nonesterified; Follow-Up Studies; Followup Studies; Free Fatty Acids; Fructose; Gallbladder Calculus; Gallbladder Stone; Gallstones; Glucose; Glucose Intolerance; Goals; Gobernadora; Gout; HDL Cholesterol; Health; Hepatic; Hepatic Cells; Hepatic Disorder; Hepatic Parenchymal Cell; Hepatocyte; High Density Lipoprotein Cholesterol; Human, Adult; Hyperlipemia; Hyperlipidemia; Hypertension; In Vitro; Incidence; Individual; Infertility; Inflammatory; Insulin Resistance; Intervention; Intervention Strategies; Kidney Diseases; L-FABP; LDL; Laboratories; Laboratory Study; Larrea; Lead; Less-Developed Countries; Less-Developed Nations; Levulose; Life Style; Lifestyle; Linoleate-Oxygen Oxidoreductase; Linoleate[{..}]oxygen 13-oxidoreductase; Lipids; Lipoproteins, HDL Cholesterol; Lipoproteins, LDL; Lipoproteins, VLDL; Lipoxidase; Lipoxygenase; Lipoxygenase Inhibitors; Liver; Liver Cells; Liver diseases; Low-Density Lipoproteins; MODY; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Medication; Mental disorders; Mental health disorders; Messenger RNA; Metabolic; Metabolic syndrome; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Methods and Techniques; Methods, Other; Mice; Mice, Transgenic; Mitochondria; Mobility Shift Assay; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Murine; Mus; NAFLD; NASH; NDGA; NIDDM; Nephropathy; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-alcoholic steatohepatitis; Nonesterified Fatty Acids; Nordihydroguaiaretic Acid; Nuclear; Nuclear Receptors; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Ovarian; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical activity; Plants; Plants, General; Plasma; Population; Prebeta-Lipoproteins; Prevalence; Production; Proteins; Psychiatric Disease; Psychiatric Disorder; RNA, Messenger; RT-PCR; RTPCR; Rat; Rattus; Renal Disease; Reporter; Reticuloendothelial System, Serum, Plasma; Reverse Transcriptase Polymerase Chain Reaction; Risk; Risk Factors; Rodent Model; Role; Serum, Plasma; Syndrome; T2D; T2DM; Techniques; Testing; Therapeutic Agents; Third-World Countries; Third-World Nations; Trans-Activation (Genetics); Transactivation; Transgenic Mice; Triacylglycerol; Triglycerides; Truncal obesity; Type 2 diabetes; Type II diabetes; Under-Developed Countries; Under-Developed Nations; United States; Unspecified Mental Disorder; VLDL; VLDL triacylglycerol; VLDL triglyceride; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Very low density lipoprotein; Weight Loss; Weight Reduction; Western Blotting; Western Blottings; Western Immunoblotting; Work; adipogenesis; adiposity; adult human (21+); adult onset diabetes; alpha-Lipoprotein Cholesterol; aminoglycoside N1-acetyltransferase; attenuation; beta-Lipoproteins; blood lipid; body system, hepatic; body weight loss; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; carotene oxidase; cholelith; combination therapy; combined modality treatment; combined treatment; coping; corpulence; corpulency; corpulentia; diabetes; diabetes risk; drug/agent; excess adiposity in midsection; fat metabolism; fatty acid-transport protein; feeding; gel shift assay; gene product; heavy metal Pb; heavy metal lead; hepatopathy; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vivo; infertile; insulin resistant; insulin sensitivity; interventional strategy; ketosis resistant diabetes; kidney disorder; lipid biosynthesis; lipid metabolism; lipogenesis; lipoprotein, VLDL triglyceride; liver disorder; mRNA; male-type obesity; malignancy; maturity onset diabetes; mental illness; mitochondrial; multimodality therapy; neoplasm/cancer; non-alcohol fatty liver; non-alcohol induced steatohepatitis; non-alcoholic fatty liver; non-alcoholic steato-hepatitis; nonalcohol fatty liver; nonalcoholic fatty liver; nonalcoholic steato-hepatitis; nonalcoholic steatohepatitis; obese; obese people; obese person; obese population; organ system, hepatic; overexpression; oxidation; paromomycin acetyl transferase; particle; protein blotting; psychological disorder; public health relevance; renal disorder; reverse transcriptase PCR; social role; tool; transcription factor; trunk obesity; unable to bear children; uptake; very low density lipoprotein triglyceride; visceral obesity; waist-predominant obesity; wt-loss",Hypo-Lipidemic Actions of Creosote Bush-Derived NDGA," PROJECTIVE NARRATIVE Metabolic syndrome has emerged as a constellation of risk factors that markedly increase the risk of type 2 diabetes and cardiovascular disease (CVD). Because the prevalence of diabetes and obesity is rising at an alarming rate, the incidence of this morbid syndrome is expected to continue to grow both in the United States and worldwide, and thus, there is a greater need for the development of new safe and effective combinations of drugs, more efficacious drugs as well as multifunctional drugs that can be used as valuable clinical tools in the management of this syndrome. The goal of this project is to elucidate the molecular mechanism by which NDGA lowers elevated blood lipids by improving the lipid metabolism in the liver. A greater understanding of the molecular mechanism(s) by which NDGA exerts its hypolipidemic action is likely to provide important clues which eventually may lead to the development of NDGA (or some form of its derivative) as a new, effective therapeutic agent in the management of dyslipidemia and possibly other central components of the metabolic syndrome.",92473,ZRG1,Special Emphasis Panel,,2,358000,
7777884,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL092963-02,,NHLBI:381250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,ANATOMY/CELL BIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"BUDINGER, GR SCOTT ;JONES, JONATHAN C. (contact);",1867293 (contact);1916929;,5R01HL092963,04/01/2009,01/31/2014,"500-kDa HD1 protein; ARDS; ARDS, Human; ARDSs, Human; Accelerated interstitial pneumonitis; Acute; Acute Interstitial Pneumonitis; Acute Pulmonary Injury; Adenoviridae; Adenoviruses; Adhesions; Adult RDS; Adult Respiratory Distress Syndrome; Alveolar; Animal Model; Animal Models and Related Studies; Animals; Assay; Basal lamina; Behavior; Bioassay; Biologic Assays; Biological Assay; Bleo; Bleomycin; Bleomycin Antibiotic; Body Tissues; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell Signaling; Cell Surface Receptors; Cell physiology; Cell-Extracellular Matrix; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Cessation of life; Collagen; Connective Tissue; Cranin; Data; Death; Deposit; Deposition; Desquamative interstitial pneumonitis; Determinants, Mortality; Development; Disease; Disease Progression; Disorder; Dystroglycan; Dystroglycans; ECM; Environment; Epithelial; Epithelial Cells; Exhibits; Extracellular Matrix; Fibrosing Alveolitis; Fibrosis; Future; GFAC; Glycoprotein GP-2; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hamman-Rich syndrome; Idiopathic ARDS; Idiopathic Interstitial Pneumonia; In Situ; In Vitro; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Laminin; Lundbeck Brand of Bleomycin Sulfate; Lung; Lung Alveolar Epithelia; Lung Injury, Acute; Lung Parenchyma; Lung Tissue; Lung diseases; Mammals, Mice; Mediating; Mesenchymal; Mice; Mice, Knock-out; Mice, Knockout; Mortality Determinants; Motility; Motility, Cellular; Murine; Mus; Myofibroblast; Non-specific interstitial neumonia/fibrosis; Null Mouse; Outcome; Patients; Phenotype; Proteins; Publishing; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Fibrosis; Receptor Protein; Receptors, Cell Surface; Resolution; Respiratory Disease; Respiratory Disorder; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory physiology; Role; Scaffolding Protein; Series; Shock Lung; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure of alveolar epithelium; Structure of parenchyma of lung; Subcellular Process; Testing; Tissues; Usual Interstitial Pneumonia; Usual Interstitial Pneumonitis; acute lung injury; alveolar epithelium; base; biological signal transduction; cell behavior; cell motility; cell type; diffuse interstitial pulmonary fibrosis; disease/disorder; gene product; hemidesmosomal protein HD1; idiopathic pulmonary fibrosis; in vivo; injured; insight; lung disorder; lung function; lung injury; migration; model organism; mouse model; novel; plectin; public health relevance; pulmonary; receptor; repair; repaired; respiratory function; social role",Substrate stiffness regulates alveolar epithelial cell behavior," In certain pulmonary diseases, lung tissue becomes fibrotic and stiffens. We propose to assay how the stiffness of the lung regulates the function of its cellular components. Our results will provide novel insight into the mechanisms of disease progression and has implications for future therapies.",92963,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,2,381250,
7779980,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL092994-02,,NHLBI:390000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"MARSHALL, HARVEY E;",1863780;,5R01HL092994,04/01/2009,01/31/2013,"ARDS; ARDS, Human; ARDSs, Human; Active Oxygen; Acute; Acute Pulmonary Injury; Adaptor Protein; Adaptor Signaling Protein; Address; Adult RDS; Adult Respiratory Distress Syndrome; Alveolar Macrophages; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Apoptosis; Apoptosis Pathway; Aspiration, Respiratory; Attenuated; Autoregulation; BPD; Bp50; Breathing; Bronchopulmonary Dysplasia; CD40; CDW40; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Common Rat Strains; Complex; DNA Binding; DNA Binding Interaction; Data; Dehydrogenases; Development; Disease; Disorder; Dose; Dysfunction; EC 1.14.13.39; EC 2.7; EDRF Synthase; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Evolution; Functional disorder; Gases; Genetic; Guanylyl Cyclase-Activating Factor Synthase; Harvest; Hepatocyte Nitric Oxide Synthase; Homeostasis; INFLM; INOS; Immune response; Immunoglobulin Enhancer-Binding Protein; In Vitro; Incidence; Inducible Nitric Oxide Synthase; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Inhalation; Inhaling; Injury; Inspiration, Respiratory; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; Knowledge; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Liquid substance; Lung; Lung Inflammation; Lung Injury, Acute; Lung Parenchyma; Lung Tissue; Lung diseases; METBL; MGC9013; Macrophage Nitric Oxide Synthase; Macrophages, Alveolar; Mammals, Mice; Mammals, Rats; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Mercaptans; Mercapto Compounds; Metabolic Processes; Metabolism; Mice; Modeling; Modification; Molecular; Mononitrogen Monoxide; Mortality; Mortality Vital Statistics; Murine; Mus; NADPH-Diaphorase; NF-kB; NF-kappa B; NF-kappaB; NFKB; NO Synthase; NOS Type II; NOS2; NOS2A; NOS2A gene; NOS2A protein, human; NOS3; NOS3 gene; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; O element; O2 element; Oxidoreductase; Oxygen; Oxygen Radicals; Pathway interactions; Pb element; Phosphotransferases; Physiological Homeostasis; Physiopathology; Play; Pneumonia; Pneumonitis; Population; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Prevention; Pro-Oxidants; Production; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; Pulmonary Macrophages; Rat; Rattus; Reaction; Reactive Oxygen Species; Reductases; Regulation; Research Proposals; Respiratory Disease; Respiratory Disorder; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Shock Lung; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Structure of parenchyma of lung; Sulfhydryl Compounds; Supportive Therapy; Supportive care; TLR4; TLR4 gene; TNFRSF5; TNFRSF5 gene; TOLL; Testing; Therapeutic; Thiols; Transcription Factor NF-kB; Translating; Translatings; Transphosphorylases; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; United States; Wild Type Mouse; acute lung injury; aerosolized; airway epithelium; airway epithelium infalmmation; airway inflammation; base; biological signal transduction; chemical property; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; clinical significance; clinically significant; cytokine; denitration; disease/disorder; endothelial cell derived relaxing factor; ethyl nitrite; extracellular; fluid; gene product; hToll; heavy metal Pb; heavy metal lead; host response; human NOS2A protein; iNO; iNOS enzyme; immunoresponse; infant chronic lung disease; inhaled nitric oxide; inspiration; kappa B Enhancer Binding Protein; language translation; liquid; lung disorder; lung injury; macrophage; neonatal chronic lung disease; new therapeutics; newborn chronic lung disease; next generation therapeutics; nitration; nitric oxide synthase, Type II; novel therapeutics; nuclear factor kappa beta; p50; p65; pathophysiology; pathway; public health relevance; pulmonary; response; social role; sulfhydryl group; transcription factor; treatment effect","S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury"," Relevance: Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a disease with an annual incidence in the United States of approximately 190,000 cases and a mortality rate between 40-50%. Despite its clinical significance, the pathophysiology of ALI/ARDS remains poorly understood with treatment limited to supportive care. This research proposal will address the importance of endogenously-produced molecules termed S-nitrosothiols, in controlling the inflammation that is associated with ALI/ARDS. The knowledge gained from the proposed studies could lead to the development of new therapies that target inflammation in ALI/ARDS and other pulmonary disorders.",92994,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,2,390000,
7780038,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL093535-02,,NHLBI:392500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DALLAS,UNITED STATES,PEDIATRICS,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"SAVANI, RASHMIN C;",1864983;,5R01HL093535,04/01/2009,01/31/2013,"0-11 years old; 0-6 weeks old; 21+ years old; A1PI; ABC Transport Protein; ABC Transporter Protein; ABC Transporters; AGTR2; AGTR2 gene; AT2; ATP-Binding Cassette Transporters; Acids; Adult; Adverse effects; Alveolar; Antibodies, Blocking; Binding; Binding (Molecular Function); Birth; Bleo; Bleomycin; Bleomycin Antibiotic; Blocking Antibodies; CD168 Antigen; CD44; CD44 Adhesion Receptor; CD44 Antigens; CD44 gene; CD44 molecule; Cardiorespiratory distress syndrome of newborn; Cell-Extracellular Matrix; Cells; Cessation of life; Chaperone; Chemicals; Child; Child Youth; Childhood; Children (0-21); Chronic lung disease; Congenital alveolar dysplasia; Data; Death; Development; Disease; Disorder; ECM; Endoplasmic Reticulum; Epithelial Cells; Ergastoplasm; Extracellular Matrix; FLR; Failure (biologic function); Fibrosis; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, Human; Glycosaminoglycans; HMMR; HMMR protein, human; HUTCH-1; Hermes Antigen; Heterozygote; Human; Human Genetics; Human, Adult; Human, Child; Human, General; Hyaluronan; Hyaluronan-Binding Protein; Hyaluronan-Mediated Motility Receptor; Hyaluronic Acid; Hyaluronic Acid Binding Protein; Hyperoxia; ILD; INFLM; IRDS of newborn; Idiopathic respiratory distress syndrome; Idiopathic respiratory distress syndrome of newborn; In Vitro; Infant, Newborn; Inflammation; Injury; Interstitial Lung Diseases; Intracellular Hyaluronic Acid Binding Protein; Knockout Mice; Lamellar Body; Liver; Lundbeck Brand of Bleomycin Sulfate; Lung; Lung Diseases, Interstitial; Lung diseases; Lysosomes; MDU3; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular Chaperones; Molecular Interaction; Morphology; Mortality; Mortality Vital Statistics; Mucopolysaccharides; Murine; Mus; Mutation; Neonatal; Neonatal Respiratory Distress Syndrome; Newborn Infant; Newborn RDS; Newborn Respiratory Distress Syndrome; Newborns; Null Mouse; Parturition; Pathogenesis; Peptides; Pgp1; Phenotype; Phosphatides; Phospholipids; Predisposition; Process; Proteins; Publishing; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein SP-B; Pulmonary hypoperfusion syndrome of newborn; Quality Control; RDS, type I; Receptor Protein; Receptors, Hyaluronan; Resolution; Respiratory Disease; Respiratory Disorder; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome, Perinatal; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Respiratory distress; Role; SP-B Protein; SP-B peptide; Secretory Granules; Secretory Vesicles; Stress; Surfactant Protein SP-B; Surfactant deficiency syndrome neonatal; Surfactant protein B; Susceptibility; System; System, LOINC Axis 4; Testing; Therapeutic; Transgenic Mice; Transgenic Organisms; Treatment Side Effects; Trypsin Inhibitor, alpha 1-Antitrypsin; Type II Pneumocyte; Wet lung disease of newborn; adult human (21+); alpha 1 Antiprotease; alpha 1-Antiproteinase; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; alpha 1-Protease Inhibitor; alpha 1-Proteinase Inhibitor; alveolar lamellar body; alveolar type II cell; biological adaptation to stress; body system, hepatic; children; cystic fibrosis of the liver; disease/disorder; distress; respiratory, newborn; endoplasmic reticulum stress; experiment; experimental research; experimental study; failure; gene product; genome mutation; gp85; human HMMR protein; human disease; idiopathic respiratory distress of newborn; improved; insight; interest; liver cystic fibrosis; lung disorder; lung injury; macrophage; membrane structure; mouse model; mutant; neonatal RDS; neonatal death; neonate; newborn human (0-6 weeks); organ system, hepatic; oxygen stress (breathing); pediatric; public health relevance; pulmonary; reaction; crisis; receptor; reconstitute; reconstitution; research study; respiratory distress syndrome; response; side effect; social role; stress response; stress; reaction; surfactant; surfactant deficiency; therapy adverse effect; trafficking; transgenic; treatment adverse effect; youngster",ABCA3 and the Response to Lung Injury," Mutations in the gene for the ABCA3 transporter cause a variety of lung diseases that result in either death in the immediate newborn period or chronic lung disease in children and into adulthood. We want to develop mouse models of the human mutations in this gene so as to study their susceptibility to lung injury, the mechanisms of disease, and to test potential therapies. Since they have been implicated in inflammation after lung injury, we are also interested in studying the role of the extracellular matrix molecule hyaluronan (HA) and its receptors in the disease processes associated with ABCA3 mutations. We believe that the data from these studies will have implications for the pathogenesis of genetic lung diseases as well as provide vital information in the development of potential therapies. Further, the findings emanating from these studies will be relevant to other severe conditions of the lung (e.g. cystic fibrosis) and liver (e.g. alpha-1-antitrypsin deficiency) that have similar mechanisms of disease.",93535,ZRG1,Special Emphasis Panel,,2,392500,
7754077,R01,HL,5,,01/01/2010,12/31/2010,PAR-08-023,5R01HL094317-02,,NHLBI:342000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MILWAUKEE,UNITED STATES,PHYSIOLOGY,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"BEARD, DANIEL A;",1869171;,5R01HL094317,01/01/2009,12/31/2012,"ATP Synthesis; ATP Synthesis Pathway; ATP biosynthesis (oxidative); Accounting; Acetoacetates; Acetyl CoA; Acetyl Coenzyme A; Acute; Affect; Analysis, Data; Biochemical Pathway; Biological Models; Blood; Blood Pressure, High; Body Tissues; Brain Hypoxia-Ischemia; Carbohydrates; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiomyopathies; Cells; Citric Acid Cycle; Coenzyme A, S-acetate; Common Rat Strains; Computer Simulation; Computerized Models; D-Glucose; Data; Data Analyses; Development; Dextrose; Disease; Disease model; Disorder; Disorder of muscle, unspecified; Dysfunction; Electrophysiology; Electrophysiology (science); Energy Expenditure; Energy Metabolism; Engineering; Engineerings; Enzymes; Equilibrium; Exercise; Exercise, Physical; Fats; Fatty Acids; Fatty acid glycerol esters; Functional disorder; Genetic Models; Glucose; Glycolysis; Goals; Heart; Heart Diseases; Heart failure; Heterogeneity; Hormonal; Hydroxybutyrates; Hypertension; Hypoxia-Ischemia, Brain; Intermediary Metabolism; Intervention; Intervention Strategies; Ischemia; Ketone Bodies; Kinetic; Kinetics; Krebs Cycle; Lead; METBL; Mammals, Rats; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Metabolic; Metabolic Networks; Metabolic Processes; Metabolism; Mitochondria; Model System; Modeling; Models, Biologic; Models, Computer; Models, Genetic; Molecular; Muscle Cells; Muscle Cells, Mature; Muscle Disease; Muscle Disorders; Muscle disease or syndrome; Muscle, Cardiac; Muscle, Heart; Muscular Diseases; Mycocardium Disease; Myocardial; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; Myocardium; Myocytes; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Network-based; Neurophysiology / Electrophysiology; O element; O2 element; Organ; Organelles; Outcome; Oxidative Phosphorylation; Oxidative Phosphorylation Pathway; Oxygen; PDH kinase; Pathway interactions; Pb element; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiological; Physiopathology; Pressure; Pressure- physical agent; Protocol; Protocols documentation; Pyruvate; Pyruvates; Rat; Rattus; Recovery; Reticuloendothelial System, Blood; Simulation, Computer based; Source; Starvation; Stress; Suspension substance; Suspensions; System; System, LOINC Axis 4; TCA cycle; Tars; Therapeutic; Therapeutic Effect; Time; Tissues; Translating; Translatings; Tricarboxylic Acid Cycle; Validation; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Work; balance; balance function; base; cardiac failure; cardiac muscle; case control; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; dehydrogenation; design; designing; disease/disorder; disorder model; enzyme activity; experiment; experimental research; experimental study; fatty acid oxidation; fatty acid transport; flexibility; glycogenolysis; heart disorder; heart hypoxia; heart muscle; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; hypoxia ischemia; improved; improved functioning; in silico; in vivo; interventional strategy; language translation; mitochondrial; model development; models and simulation; muscular disorder; myocardial hypoxia; myocardium disorder; oxidation; oxygen transport; pathophysiology; pathway; pressure; pyruvate dehydrogenase kinase; reconstitute; reconstitution; research study; respiratory; response; simulation; suspension; tool; virtual simulation",Mechanisms of Metabolic Dysfunction in Heart Disease,,94317,ZRG1,Special Emphasis Panel,,2,342000,
7749984,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL094585-02,,NHLBI:334966;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,,05,074438755,US,IL,606143394,CHILDREN'S MEMORIAL HOSPITAL (CHICAGO),"HARRIS, ANN ;",7845023;,5R01HL094585,01/01/2009,12/31/2012,"Address; Affect; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Binding; Binding (Molecular Function); Bio-Informatics; Bioinformatics; Body Tissues; Boundary Elements; CF patients; CFTR; CFTR Protein; CHIP assay; Canal of Wirsung; Cell Communication and Signaling; Cell Line; Cell Lineage; Cell Lines, Strains; Cell Signaling; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chloride Channels; Chromatin; Chromatin Structure; Clinical; Complex; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Methylation; DNA-Protein Interaction; DNase; Deoxyribonucleases; Development; Disease; Disorder; Elements; Elements, Boundary; Environment; Epithelial; Epithelial Cells; Epithelium; Epithelium, Intestinal; Gastrointestinal Tract, Pancreas; Gene Action Regulation; Gene Cluster; Gene Delivery; Gene Expression; Gene Expression Regulation; Gene Proteins; Gene Regulation; Gene Regulation Process; Gene Therapy Vectors; Gene Transduction Agent; Gene Transduction Vectors; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genes, Regulator; Genetic Alteration; Genetic Change; Genetic Intervention; Genetic defect; Genome; Genomics; Globin; Goals; Hematologic Body System; Hematopoietic; Hematopoietic Body System; Hematopoietic System; Histone Acetylation; Human; Human, General; In Vitro; Individual; Infection; Intercistronic Sequence; Intergenic Sequence; Intervention, Genetic; Intestinal; Intestines; Intracellular Communication and Signaling; Ion Channels, Chloride; Knowledge; Lead; Length of Life; Longevity; Lung; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Methylation; Miscellaneous Antibiotic; Molecular; Molecular Biology, Gene Therapy; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Mucoviscidosis; Mutate; Mutation; Nucleases, DNA; Organ System, Hematologic; Pancreas; Pancreatic; Pancreatic duct; Pattern; Pb element; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Prevention; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Gene Products; Protein Methylation; Proteins; Protocol; Protocols documentation; RNA, Messenger; Recurrence; Recurrent; Regulation; Regulator Genes; Regulatory Element; Regulatory Pathway; RegulatoryElement; Research; Respiratory Failure; Respiratory System, Lung; Route; Sequence, Intergenic; Signal Transduction; Signal Transduction Systems; Signaling; Specialized Epithelial Cell; Specificity; Structure of intestinal epithelium; Techniques; Testing; Therapeutic; Therapy, DNA; Time; Tissues; Trans-Acting Factors; Trans-Activators; Transact; Transactivators; Transcriptional Regulatory Elements; Transgenes; Work; airway epithelium; base; biological signal transduction; bowel; cell type; chromatin immunoprecipitation; clinical significance; clinically significant; conformation; conformational state; cultured cell line; cystic fibrosis patients; cystic fibrosis transmembrane regulator; design; designing; disease/disorder; effective therapy; experiment; experimental research; experimental study; gene product; gene therapy; genetic element; genetic therapy; genome mutation; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; insight; intestinal epithelium; life span; lifespan; lung development; mRNA; new therapeutics; next generation therapeutics; novel; novel therapeutic intervention; novel therapeutics; p-Globin; patients with CF; patients with cystic fibrosis; prevent; preventing; programs; public health relevance; pulmonary; regulatory gene; research study; respiratory; respiratory insufficiency/failure; success; tool; trans acting element; trans acting factor (genetic); transcription factor; vector",Tissue-specific regulation of a gene essential for normal airway epithelia," The cystic fibrosis transmembrane conductance regulator gene (CFTR), that when mutated causes CF, has a complex pattern of tissue-specific and temporal regulation. The elements that control this are, in general, poorly characterized. Our team has made substantial progress on identifying and elucidating the control mechanisms for CFTR. The current research program builds upon this progress and concentrates on elucidating novel regulatory mechanisms that may be particularly relevant to CFTR expression in the airway. Translational opportunities that may arise from this work include modulating CFTR expression in vivo and the construction of efficient, tissue-specific gene therapy vectors.",94585,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,2,334966,
7775097,R01,HL,5,,01/01/2010,12/31/2010,PA-07-070,5R01HL094849-02,,NHLBI:449820;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,MIAMI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"HARE, JOSHUA M;",1897640;,5R01HL094849,02/15/2009,12/31/2013,"Active Oxygen; Adrenergic Agents; Adrenergic Drugs; Adrenergics; Apoptosis; Apoptosis Pathway; Attention; Autoregulation; Binding; Binding (Molecular Function); Bioavailability; Biologic Availability; Biological Availability; Bizzozero's corpuscle/cell; Blood Coagulation Factor IV; Blood Platelets; Ca++ element; Calcium; Cardiac Myocytes; Cardiac infarction; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cause of Death; Caveolae; Caveolas; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Coagulation Factor IV; Cysteine; Deetjeen's body; Dehydrogenases; Disease; Disorder; Dysfunction; EC 1.1.3.22; EC 1.14.13.39; EDRF Synthase; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Energy Expenditure; Energy Metabolism; Enzymes; Equilibrium; Factor IV; Functional disorder; GSNOR, mouse; Generations; Grant; Guanylyl Cyclase-Activating Factor Synthase; Half-Cystine; Hayem's elementary corpuscle; Health; Heart; Heart failure; Heart myocyte; Homeostasis; Human; Human, General; Hypoxanthine Dehydrogenase; Hypoxanthine Oxidase; Hypoxanthine-Xanthine Oxidase; In Vitro; Injury; Intracellular Communication and Signaling; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Isoforms; Knock-out; Knockout; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Cysteine; LV remodeling; Left Ventricular Function; Left Ventricular Remodeling; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow platelet; Mediating; Mercaptans; Mercapto Compounds; Methods; Mice; Modeling; Molecular Interaction; Mononitrogen Monoxide; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocytes, Cardiac; NADPH-Diaphorase; NO Synthase; NOS1; NOS1 gene; NOS3; NOS3 gene; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Organ System, Cardiovascular; Organelles; Outcome; Oxidases; Oxidation-Reduction; Oxidative Stress; Oxidoreductase; Oxygen Radicals; Pathway interactions; Patients; Phenotype; Physiologic Availability; Physiological Homeostasis; Physiopathology; Platelets; Play; Pro-Oxidants; Production; Protein Isoforms; Proteins; Publishing; Purine-Xanthine Oxidase; Reactive Oxygen Species; Redox; Reductases; Regulation; Relaxation; Reporting; Reticuloendothelial System, Platelets; Role; S-nitrosoglutathione reductase, mouse; SKIL; SKIL gene; SNO; Sarcolemma; Sarcoplasmic Reticulum; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Source; Sulfhydryl Compounds; Testing; Thiols; Thrombocytes; Vascular blood supply; Vascular, Heart; Ventricle Remodelings, Left; Ventricular Function, Left; Work; Xanthine Oxidase; Xanthine[{..}]oxygen oxidoreductase; adrenergic; balance; balance function; base; bioavailability of drug; biological signal transduction; blood supply; cardiac failure; cardiac infarct; cardiomyocyte; cardiovascular disorder; circulatory system; coronary attack; coronary infarct; coronary infarction; disease/disorder; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; gene product; heart attack; heart infarct; heart infarction; heart ischemia; improved; in vivo; inhibitor; inhibitor/antagonist; insight; mouse S-nitrosoglutathione reductase; myocardial ischemia/hypoxia; myocardium ischemia; new therapeutics; next generation therapeutics; novel; novel therapeutics; oxidation reduction reaction; pathophysiology; pathway; public health relevance; research study; social role; sulfhydryl group; thrombocyte/platelet; vascular supply",Nitroso/redox balance in myocardial infarction," Project Narrative Myocardial infarction occurs when blood supply to the heart is inadequate and this represents the leading cause of death worldwide. In this Grant, we will explore the mechanisms through which the heart protects itself against injury. Our findings will have implications for developing new therapeutic strategies for myocardial infarction and other related common diseases.",94849,MIM,Myocardial Ischemia and Metabolism Study Section,,2,449820,
7795922,R01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5R01HL095716-02,,NHLBI:381100;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,DERMATOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"XU, JINGSONG ;",9495566;,5R01HL095716,04/01/2009,01/31/2014,"ARDS; ARDS, Human; ARDSs, Human; ATP-protein phosphotransferase; ATP[{..}]myosin-light-chain O-phosphotransferase; Actins; Acute; Acute Pulmonary Injury; Address; Adult RDS; Adult Respiratory Distress Syndrome; Affinity; Avidity; Blood Coagulation Factor IV; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Vessels; Body Tissues; C-terminal Src kinase; CSK; CSK Protein Kinase; CSK-src; Ca++ element; Calcium; Calcium Ion Signaling; Calcium Signaling; Cell Attachment; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Matrix Adhesions; Cell-Matrix Junction; Cellular Matrix; Cellular Migration; Coagulation Factor IV; Cytoskeletal System; Cytoskeleton; DNA Sequence Rearrangement; Data; Development; EC 2.7.1.117; Endothelial Cells; Endothelium; Equilibrium; Extracellular Matrix, Integrins; FLJ12216; Factor IV; Feedback; Figs; Figs - dietary; Generations; Goals; H2O2; Heterophil Granulocyte; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; INFLM; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Integrins; Intracellular Communication and Signaling; Isoforms; KRP; Killings; LPS; Link; Lipopolysaccharides; Lung; Lung Inflammation; Lung Injury, Acute; Lung diseases; MAC393 antigen; MLCK; MLCK108; MLCK210; MYLK; MYLK gene; MYLK2; Mammals, Mice; Marrow Neutrophil; Mediating; Mice; Modeling; Molecular; Motility; Motility, Cellular; Murine; Mus; Muscle; Muscle Tissue; Myosin II; Myosin Kinase; Myosin LCK; Myosin Light Chain Kinase; Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes; Myosin Light Chains; Myosin Light Polypeptide Kinase; Myosin Regulatory Light-Chain Kinase; Myosin Type II; Myosin light chain kinase 2, skeletal/cardiac muscle; NADPH Oxidase; Neutrophil Activation; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Oxidants; Oxidizing Agents; Pathogenesis; Pathway interactions; Permeability; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Prevention; Production; Protein Isoforms; Protein Kinase; Protein-Tyrosine Kinase CYL; Protein-Tyrosine Kinases, src; Pulmonary Diseases; Pulmonary Disorder; Rearrangement; Respiratory Disease; Respiratory Disorder; Respiratory Distress Syndrome, Acute; Respiratory Distress Syndrome, Adult; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; SGP-2 protein; SGP2; SP 40,40 protein; Shock Lung; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; TLR4; TLR4 gene; TOLL; TRPM-2 protein; TRPM2; Testing; Tissues; Tyrosine-Protein Kinase CSK; X-ray-inducible protein 8; XIP8 protein; acute lung injury; anti-microbial; antimicrobial; apoJ protein; apolipoprotein J; balance; balance function; base; biological signal transduction; c-src Kinase; c-src Tyrosine Kinase; carboxy-terminal Src kinase; cell motility; clusterin; complement lysis inhibitor; complement-associated protein SP-40,40 protein; electron acceptor; experiment; experimental research; experimental study; glycogen synthase a kinase; hToll; hydroxyalkyl protein kinase; in vivo; intracellular skeleton; ionizing radiation-induced protein-8; lung disorder; lung injury; microbial; migration; neutrophil; novel; pathway; phosphorylase b kinase kinase; polymerization; protein-tyrosine kinase C-terminal Src kinase; protein-tyrosine kinase c-src; public health relevance; pulmonary; research study; smooth muscle myosin light chain kinase; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; sulfated glycoprotein 2; testosterone-repressed prostate message-2 protein; vascular",Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury," We propose to study the role of a protein kinase, non-muscle myosin light chain kinase (MLCK) in bacterial induced inflammatory lung injury, the primary cause of the acute respiratory distress syndrome (ARDS). We hope that through the understanding of the novel function of this MLCK isoform, more effective strategies will be developed for the prevention and treatment of lung inflammation and the resultant injury.",95716,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,2,381100,
7753660,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH036295-25,,NIMH:365835;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"BRUDER, GERARD E;",1882507;,5R01MH036295,09/28/1982,12/31/2012,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Accounting; Acute; Affective Disorders; Amfebutamone; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Auditory; Behavioral; Brain; Bupropion; Cell Nucleus; Characteristics; Chronic; Clinical; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Cognitive; Combined Modality Therapy; Common Rat Strains; Dependence; Depressed mood; Depression; Development; Diagnostic; Disease remission; Dopamine Reuptake Inhibitors; Dopamine Uptake Inhibitors; Dorsal; Drugs; Emotional Depression; Encephalon; Encephalons; Enteramine; Escitalopram; Evaluation; Event; Event-Related Potentials; Goals; Hippophaine; Human; Human, General; Individual; Investigators; Levarterenol; Levonorepinephrine; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medication; Mental Depression; Mood Disorders; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocognitive; Neurocyte; Neurons; Noradrenaline; Norepinephrine; Nucleus; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Prospective Studies; RMSN; Randomized; Rat; Rattus; Remission; Research; Research Personnel; Researchers; Rest; SSRI; Sample Size; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Serotonin; Services; Specificity; Stimulus; Symptoms; Symptoms of depression; Testing; Therapeutic; Therapeutic Trials; Therapy Clinical Trials; Translating; Translatings; base; behavior test; behavioral test; buproprion; clinical investigation; combination therapy; combined modality treatment; combined treatment; comparative efficacy; depressed; depressive; depressive symptoms; drug/agent; event related potential; interest; language translation; multimodality therapy; neurocognitive test; neuronal; novel; pre-clinical; preclinical; preclinical study; public health relevance; randomisation; randomization; randomly assigned; response; sadness; serotonin reuptake inhibitor; trait; treatment response; trial comparing",Behavioral ERP and EEG Asymmetry in Affective Disorders,,36295,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,25,365835,
7764737,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH049698-18,,NIMH:344094;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CINCINNATI,UNITED STATES,PSYCHIATRY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"HERMAN, JAMES P;",1866795;,5R01MH049698,09/15/1992,01/31/2013,"Acute; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anatomic; Anatomical Sciences; Anatomy; Area; Bed Nucleus of Stria Terminalis; Behavioral; Cell Communication and Signaling; Cell Signaling; Cognitive; Common Rat Strains; Cornu Ammonis; Data; Depression; Development; Disease; Disorder; Emotional; Emotional Depression; FLR; Failure (biologic function); Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Image; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Label; Lead; Lesion; Link; Major Depressive Disorder; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Mediating; Mental Depression; Methods; Modeling; Moods; Nerve Cells; Nerve Unit; Nervous; Nervous System, Pituitary; Neural Cell; Neural Pathways; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Nucleic Acid Regulatory Sequences; Nucleus Tractus Solitarii; Nucleus solitarius; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pathology; Pathway interactions; Pb element; Physiologic; Physiological; Pituitary; Pituitary Gland; Play; Position; Positioning Attribute; Prefrontal Cortex; Process; Psychological Stress; Rat; Rattus; Regulation; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Resolution; Rodent; Rodentia; Rodentias; Role; Science of Anatomy; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solitary Nucleus; Stimulus; Stress; Stress, Psychological; Stria Terminalis Nucleus; Structure of paraventricular nucleus; Structure of terminal stria nuclei of preoptic region; Symptoms of depression; Testing; Work; acute stress; amygdaloid nuclear complex; anatomy; biological adaptation to stress; biological signal transduction; depressive; depressive symptoms; disease/disorder; failure; genetic regulatory element; heavy metal Pb; heavy metal lead; hippocampal; hypothalamic; imaging; improved; intervention design; interventional strategy; major depression; neural; neuroimaging; neuronal; paraventricular nucleus; parvocellular; pathway; psychologic; psychological; reaction; crisis; relating to nervous system; response; social role; solitary tract nucleus; stress response; stress; reaction; stressor; therapy design; treatment design",Functional Anatomy of Limbic-Neuroendocrine Circuits,,49698,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,18,344094,
7759141,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH049981-16,,NIMH:390688;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"DOUGLAS, STEVEN DANIEL;",1891276;,5R01MH049981,07/01/1995,01/31/2013,"(2R)-(1R)-3,5-bis(trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine; 3-10C; AIDS; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS Virus Receptors; AMCF-I; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affect; Agonist; Amino Acid Sequence; Amino Acids, Basic; Anti-HIV Positivity; Arg-Lys; Astrocytes; Astrocytus; Astroglia; Autocrine Systems; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basic Amino Acids; Blood Coagulation Factor IV; Blood Plasma; Blood monocyte; Body Tissues; Brain; Brain region; C-C CKR-5; C-C CKR-5 Gene; C-C Chemokine Receptor Type 5; C-C Chemokine Receptor Type 5 Gene; CC Chemokine Receptor 5; CC-CKR-5; CC-CKR-5 Gene; CC-CKR5; CCCKR5; CCCKR5 Gene; CCL5; CCR-5; CCR-5 Gene; CCR5; CCR5 Protein; CCR5 gene; CD195 Antigen; CD195 Antigen Gene; CHEMR13; CHEMR13 Gene; CKR-5; CKR-5 Gene; CKR5; CKR5 Gene; CMKBR5; CMKBR5 Gene; CX(3)C protein; CXCL8; Ca++ element; Calcium; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Cellular biology; Chemokine (C-C Motif) Ligand 5; Chemokine (C-C Motif) Receptor 5; Chemokine (C-C) Receptor 5; Chemokine (C-C) Receptor 5 Gene; Chemokine (C-X3-C Motif) Ligand 1; Coagulation Factor IV; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Coupling; Cytokines and Inflammatory Response; Cytokines, Chemotactic; D17S136E; Defect; Depression; Differentiation Factor, B-Cell; Disease; Disorder; Disturbance in cognition; Down-Regulation; Down-Regulation (Physiology); Downregulation; Encephalon; Encephalons; Endocytosis; Euler-Gaddum Substance P; FKN protein; Factor IV; Fractalkine; GCP-1; GCP1; Gene Expression; Gene Products, RNA; Glycine cleavage system P-protein; Glycine dehydrogenase (decarboxylating); Goals; HIV; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Receptors; HIV Seroconversion; HIV Seropositivity; HIV-1; HIV-1 Fusion Co-Receptor; HIV-1 Fusion Co-Receptor Gene; HIV-I; HIV1; HPGF; HTLV-III; HTLV-III Infections; HTLV-III Receptors; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Hepatocyte-Stimulating Factor; Homologous Chemotactic Cytokines; Hortega cell; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL-8; IL6 Protein; IL8; IL8 gene; Immune; Immune system; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Impaired cognition; In Vitro; Individual; Infection; Inflammatory Response Pathway; Intercrines; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracellular Communication and Signaling; Investigation; Investigators; K60; LAV-HTLV-III; LECT; LUCT; LYNAP; Lead; Length; Life Stress; Ligands; Lymphadenopathy-Associated Virus; Lymphocyte; Lymphocytic; MDNCF; MGC17164; MGI-2; MONAP; Man (Taxonomy); Man, Modern; Marrow monocyte; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Mental Depression; Messenger RNA; Microglia; Mononuclear; Myeloid Differentiation-Inducing Protein; NAF; NK-1 Receptors; NK1R; NKIR; NRVS-SYS; Nervous System; Nervous System, Brain; Nervous system structure; Neurocognitive; Neurologic Body System; Neurologic Organ System; Neuropeptides; P-protein; P-protein, glycine decarboxylase; PBMC; Pathogenesis; Pathway interactions; Pb element; Peptides; Peripheral; Peripheral Blood Mononuclear Cell; Phagocytes; Phagocytic Cell; Phenotype; Plasma; Plasmacytoma Growth Factor; Prevalence; Production; Programs (PT); Programs [Publication Type]; Progress Reports; Protein Structure, Primary; Proteins; Public Health; RANTES; RANTES Protein, T-Cell; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Receptor Protein; Receptors, CCR5; Receptors, CKR5; Receptors, HIV; Receptors, Neurokinin-1; Regulation; Reports, Progress; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Ribonucleic Acid; Role; SCYA5; SCYB8; SIS cytokines; SIS delta; SIS-delta; SISd; SP(1-11); SP-P Receptors; Sampling; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Small Inducible Cytokine A5; Small Inducible Cytokine D1; Source; Substance P; Substance P Receptor; System; System, LOINC Axis 4; T-Cell Specific Protein p288; T-Lymphotropic Virus Type III Infections, Human; TAC1R; TACR1; TACR1 gene; TCP228; TSG-1; Tachykinin; Tachykinin Receptor 1; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral Burden; Viral Load; Viral Load result; Virus; Virus-HIV; Viruses, General; Woman; amebocyte; antibody positive AIDS test; antigen positive AIDS test; aprepitant; arginine-lysine; arginyllysine; autocrine; b-ENAP; base; biological signal transduction; body system, allergic/immunologic; calcium flux; calcium mobilization; cell biology; chemoattractant cytokine; chemokine; chemokine receptor; cingulate cortex; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cultured cell line; design; designing; disease/disorder; feeding; gene product; gitter cell; glycine decarboxylase; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; in vitro Model; interferon beta 2; lymph cell; mRNA; mRNA Expression; macrophage; membrane structure; men; men's; mesoglia; microglial cell; microgliocyte; monocyte; neurokinin 1; neuropathology; novel; novel therapeutic intervention; organ system, allergic/immunologic; pathway; peripheral blood; perivascular glial cell; programs; protein expression; protein sequence; public health medicine (field); receptor; receptor function; release of sequestered calcium ion into cytoplasm; response; seropositive (AIDS test); social role",Tachykinins Mononuclear Phagocytes and HIV-1 Infection,,49981,ZRG1,Special Emphasis Panel,,16,390688,
7766239,R01,MH,5,,01/20/2010,12/31/2010,PA-07-070,5R01MH057368-12,,NIMH:383738;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"MAYFORD, MARK R;",1905490;,5R01MH057368,07/01/1997,12/31/2012,"21+ years old; Address; Adult; Aging; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animals; Behavioral; Benign; Biochemical; Brain; Brain Part; Cell Communication and Signaling; Cell Signaling; Cells; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cornu Ammonis; Defect; Degenerative Disorder; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; Development; Disease; Disorder; Disturbance in cognition; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elements; Encephalon; Encephalons; Fore-Brain; Forebrain; Gene Expression; Genes; Genetic; Genetic Condition; Genetic Diseases; Genetic Techniques; Genetics, Human; Grant; Hereditary Disease; Hippocampus; Hippocampus (Brain); Hour; Human; Human Genetics; Human, Adult; Human, General; Impaired cognition; Impairment; Individual; Intracellular Communication and Signaling; Learning; Lesion; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Memory; Mental Depression; Mental Retardation; Mental disorders; Mental health disorders; Mice; Mice, Transgenic; Molecular; Molecular Disease; Murine; Mus; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Nuclear; PTSD; Performance; Phase; Post-Traumatic Stress Disorders; Primary Senile Degenerative Dementia; Process; Prosencephalon; Psychiatric Disease; Psychiatric Disorder; Recruitment Activity; Relapse; Research; Retrieval; Rodent; Rodentia; Rodentias; Role; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Senescence; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Structure; Synapses; Synaptic; System; System, LOINC Axis 4; Taybi syndrome; Technics, Genetic; Temporal Lobe; Testing; Tetracycline Antibiotic; Tetracyclines; Time; Time Study; Training; Transgenes; Transgenic Mice; Unspecified Mental Disorder; Work; addiction; adult human (21+); amygdaloid nuclear complex; analog; anatomy; biological signal transduction; brain cell; cognitive dysfunction; cognitive loss; cognitively impaired; degenerative condition; degenerative disease; dementia of the Alzheimer type; dementia praecox; disease/disorder; gene function; genetic disorder; hereditary disorder; hippocampal; long term memory; memory recall; memory retrieval; mental illness; model organism; molecular marker; mouse model; neuronal; neuronal patterning; normal aging; otopalatodigital (OPD) syndrome I; otopalatodigital syndrome I; primary degenerative dementia; psychological disorder; public health relevance; recruit; schizophrenic; senescent; senile dementia of the Alzheimer type; social role; temporal cortex; temporal lobe/cortex; traumatic neurosis",Regulated Genetics Studies of Memory Formation,,57368,LAM,Neurobiology of Learning and Memory Study Section,,12,383738,
7759147,R01,MH,5,,01/14/2010,12/31/2010,,5R01MH059259-11,,NIMH:587414;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,STANFORD,UNITED STATES,PSYCHOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GOTLIB, IAN H.;",1964363;,5R01MH059259,01/01/1999,12/31/2011,"Accounting; Affect; Affective; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anterior; Area; Attenuated; Behavioral; Biological; Biological Factors; Brain; Characteristics; Cognitive; Depressed mood; Depression; Development; Diagnosis; Diagnostic; Disease; Disorder; Dorsal; Drug Formulations; Dysfunction; Emotional; Emotional Depression; Emotions; Encephalon; Encephalons; Event; Exhibits; FLR; Factor, Biologic; Failure (biologic function); Feedback; Formulation; Formulations, Drug; Functional disorder; Generations; Individual; Investigation; Investigators; Lead; Maintenance; Maintenances; Major Depressive Disorder; Medial; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; Mental disorders; Mental health disorders; Modeling; Natural Products; Nervous; Nervous System, Brain; Participant; Pattern; Pb element; Persons; Physiologic; Physiological; Physiopathology; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Recovery; Regulation; Research; Research Design; Research Personnel; Researchers; Role; Series; Severities; Short-Term Memory; Stimulus; Striatum, Ventral; Structure; Study Type; Symptoms; Symptoms of depression; Testing; Unspecified Mental Disorder; Ventral Striatum; Work; amygdaloid nuclear complex; base; cingulate cortex; cognitive function; depressed; depressive; depressive symptoms; design; designing; disease/disorder; economic cost; emotion regulation; emotional stimulus; experience; failure; heavy metal Pb; heavy metal lead; improved functioning; information processing; long term memory; major depression; mental illness; negative mood; neural; neural patterning; pathophysiology; prevent; preventing; programs; psycho-physiological; psychobiologic; psychobiological; psychological disorder; relating to nervous system; repair; repaired; response; reward circuitry; reward processing; sadness; social role; stimulus processing; study design; symptomatic improvement; theories; working memory",Neural and Behavioral Aspects of Information-Processing Biases in Depression,,59259,ZRG1,Special Emphasis Panel,,11,587414,
7765510,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH059391-13,,NIMH:289137;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PISCATAWAY,UNITED STATES,PEDIATRICS,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"LEWIS, MICHAEL ;",1881436;,5R01MH059391,09/30/1996,01/31/2011,"0-11 years old; 12-20 years old; 21+ years old; 9 year old; Accounting; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Age; Aggression; Aggressive behavior; Alcohols; Anxiety; Awareness of self; Behavior; Behavioral; Belief; Biological; Biological Factors; Chemical Class, Alcohol; Child; Child Abuse and Neglect; Child Behavior; Child Sexual Abuse; Child Youth; Childhood; Childhood maltreatment; Children (0-21); Cognition; Cognitive; Complex; Conscious; Consciousness; Data; Depression; Development; Drug usage; Emotional; Emotional Depression; Emotions; Environmental Factor; Environmental Risk Factor; Event; Exhibits; Expressed Emotion; FLR; Factor, Biologic; Failure (biologic function); Family; Figs; Figs - dietary; Funding; Future; Goals; Grant; History; Hormonal Change; Human, Adult; Human, Child; Individual Differences; Intervention; Intervention Strategies; Life; Link; Longitudinal Studies; Maternal Behavior; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mental Depression; Modeling; Molestation, Sexual, Child; Moods; Mothers; Natural Products; Outcome; Parenting; Parenting behavior; Pathology; Patient Self-Report; Pattern; Personal awareness; Problem behavior; Process; Progress Reports; Puberty; Public Health; Punishment; RFP; Recording of previous events; Recruitment Activity; Relative; Relative (related person); Reliance; Reporting; Reports, Progress; Request for Proposals; Research; Research Resources; Resources; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Sampling; Self Perception; Self image; Self view; Self-Report; Severities; Sex Behavior; Sex Characteristics; Sex Differences; Sex Maturation; Sexual Activity; Sexual Behavior; Sexual Maturation; Sexual abuse; Shame; Social Development; Social Problems; Social support; Staging; Stress; Symptoms; Symptoms of depression; Testing; Time; Variant; Variation; Visit; Work; adolescence (12-20); adult human (21+); at risk behavior; behavioral problem; boys; child maltreatment; childhood sexual abuse; children; cohort; coping; cost; depressive; depressive symptoms; drug use; early adolescence; early childhood; emotion regulation; emotional distress; emotional reaction; environmental risk; externalizing behavior; failure; feeling distress; feeling upset; gender difference; girls; high risk behavior; human puberty; interest; interventional strategy; juvenile; juvenile human; juvenile sex abuse; long-term study; maltreated children; maltreatment; mistreatment; nine year old; pediatric; psychologic; psychological; public health medicine (field); recruit; response; self awareness; self knowledge; sex; sex abuse; sex activity; sexual dimorphism (noncellular); skills; social; social disturbance; social support network; success; teenage; youngster",Maltreated Children's Emotions and Self-Cognitions,,59391,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,13,289137,
7788119,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH060379-09,,NIMH:330000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CAMBRIDGE,UNITED STATES,MISCELLANEOUS,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"GRAYBIEL, ANN M;",1882632;,5R01MH060379,08/03/2000,01/31/2012,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Addictive Behavior; Address; Affect; Analysis, Data; Animals; Anxiety Disorders; Arm; Association Learning; Auditory; Basal Ganglia; Basal Nuclei; Behavior; Behavioral; Behavioral Model; Brain; Brain Diseases; Brain Disorders; CNS plasticity; Causality; Chronic; Cognitive; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Cues; Data; Data Analyses; Depression; Development; Disease; Disorder; Dopamine; Electrodes; Encephalon; Encephalon Diseases; Encephalons; Etiology; Exhibits; Fire - disasters; Fires; Gilles de la Tourette syndrome; Gilles de la Tourette's Disease; Goals; Guinon's disease; Habits; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hydroxytyramine; Idiopathic Parkinson Disease; Instruction; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigators; Learning; Lewy Body Parkinson Disease; Mammals, Rats; Man (Taxonomy); Man, Modern; Maze Learning; Medial; Memory; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Mesencephalon; Methods; Mid-brain; Midbrain; Midbrain structure; Mission; Modeling; Motor; Movement; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neuronal Plasticity; Neurons; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pattern; Primary Parkinsonism; Probability; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychological reinforcement; Rat; Rattus; Reinforcement; Reinforcement (Psychology); Research Personnel; Researchers; Rewards; SCHED; Schedule; Series; Site; Stimulus; Striate Body; Striatum; Tactile; Testing; Tic Disorder, Combined Vocal and Multiple Motor; Time; Tourette Syndrome; Tourette's; Tourette's Disease; Tourette's Disorder; Tourette's Syndrome; Training; Uncertainty; United States National Institute of Mental Health; Unspecified Mental Disorder; Upper arm; Work; analog; base; body movement; cognitive function; conditioning; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; doubt; experiment; experimental research; experimental study; habit learning; maladie des tics; mental illness; nervous system disorder; neural; neural mechanism; neural plasticity; neurological disease; neuromechanism; neuronal; neuroplasticity; neuropsychiatric; neuropsychiatry; prevent; preventing; programs; psychological disorder; relating to nervous system; research study; response; striatal; tic de Guinon",Ensemble Activity in Rat Striatum During Habit Learning,,60379,SMI,Sensorimotor Integration Study Section,,9,330000,
7765480,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH060698-09,,NIMH:371717;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,FLUSHING,UNITED STATES,PSYCHOLOGY,08,619346146,US,NY,113671597,QUEENS COLLEGE,"HALPERIN, JEFFREY M;",1868621;,5R01MH060698,12/01/1999,01/31/2012,"0-11 years old; 11 year old; 21+ years old; AD/HD; ADHD; Accounting; Active Follow-up; Address; Adolescent; Adolescent Youth; Adult; Affect; Area; Arousal; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Basal Ganglia; Basal Nuclei; Behavioral; Brain; Brain Stem; Brainstem; Causality; Cerebellum; Characteristics; Child; Child Youth; Childhood; Children (0-21); Clinical; Cognitive; Comorbidity; Corpus Striatum; Corpus striatum structure; Data; Development; Developmental Process; Diagnosis; Disease remission; Dysfunction; Encephalon; Encephalons; Etiology; Functional Magnetic Resonance Imaging; Functional disorder; Functional impairment; Generalized Growth; Grant; Growth; Heart; Heterogeneity; Hind Brain; Human, Adult; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Impairment; Impulsivity; Individual; Inferior Frontal Convolution; Inferior frontal gyrus; Investigators; Longitudinal Studies; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mesencephalon; Mid-brain; Midbrain; Midbrain structure; Modeling; Motor; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Neurocognitive; Nuclear Magnetic Resonance Imaging; Outcome; Partial Remission; Pathway interactions; Patients; Performance; Physiopathology; Position; Positioning Attribute; Probability; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Public Health; RMSN; Recovery; Recruitment Activity; Remission; Reporting; Reports, Progress; Research; Research Personnel; Researchers; Residual; Residual state; Resolution; Reticular Formation; Rhombencephalon; Sampling; Severities; Striate Body; Striatum; Symptoms; System; System, LOINC Axis 4; Technology; Testing; Thalamic structure; Thalamus; Time; Tissue Growth; Zeugmatography; adolescent substance use; adult human (21+); adult youth; attention deficit hyperactive disorder; base; children; cost; disease causation; disease control; disease etiology; disease subtype; disease/disorder etiology; disorder control; disorder etiology; disorder subtype; eleven year old; executive control; executive function; fMRI; follow-up; functional disability; hindbrain; inattention; inattentiveness; indexing; innervation; innovate; innovation; innovative; juvenile; juvenile human; long-term study; meetings; nerve supply; neural; neural circuit; neural circuitry; neuropsychological; ontogeny; pathophysiology; pathway; pediatric; proband; programs; public health medicine (field); recruit; relating to nervous system; response; striatal; thalamic; theories; young adult; youngster; youth substance use",ADHD: Neural Correlates of Adult Outcomes,,60698,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,9,371717,
7766997,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH061465-10,,NIMH:300222;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"ALREJA, MEENAKSHI ;",1895452;,5R01MH061465,04/01/2000,01/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3'5'-cyclic ester of AMP; Acetylcholine; Acetylcholinesterase Inhibitors; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antiphosphodiesterases; Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-; Brain; Brain region; CRF receptor type 1; CRF-R1; CRF1 receptor; CRH-1; Clinical Research; Clinical Study; Cognition; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Corticotropin Releasing-Factor Receptors; Corticotropin-Releasing Hormone Receptors; Crh1 receptor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotides; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyguanylate Cyclase; Depression; Disease; Disorder; Disturbance in cognition; EC 1.14.13.39; EC 2.7; EDRF Synthase; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Enzymes; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Fiber; GTP pyrophosphate-lyase (cyclizing); Glutamates; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanyl Cyclase; Guanylate Cyclase; Guanylyl Cyclase-Activating Factor Synthase; Health; Human; Human, General; Hydrolysis; Hyoscine; Image; Imagery; Impaired cognition; Inhibitors, Acetylcholinesterase; Inosinate Cyclase; Investigators; Kinases; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Glutamate; Label; Learning; Literature; Mammals, Rodents; Man (Taxonomy); Man, Modern; Memory; Mental Depression; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Mononitrogen Monoxide; Muscarinic Acetylcholine Receptor; NADPH-Diaphorase; NO Synthase; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nucleotides, Cyclic; Oxides; PDE; PDE2; PDE2 phosphodiesterase; PKA; PKG; Pathway interactions; Phosphodiesterase Antagonists; Phosphodiesterase Inhibitors; Phosphodiesterases; Phosphoric Diester Hydrolase Inhibitors; Phosphotransferases; Physiologic; Physiological; Population; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Protein Kinase A; Protein Kinase G; Psychiatric Disease; Psychiatric Disorder; Receptors, CRF; Receptors, CRH; Receptors, Corticotropin-Releasing Hormone; Receptors, Muscarinic; Recruitment Activity; Research Personnel; Researchers; Rodent; Rodentia; Rodentias; Role; Schizophrenia; Schizophrenic Disorders; Scopolamine; Slice; Stress; Techniques; Testing; Transphosphorylases; United States; Unspecified Mental Disorder; Visualization; acetylcholineesterase inhibition; acetylcholineesterase inhibitor; adenosine 3'5' monophosphate; analog; base; cAMP; cAMP-Dependent Protein Kinases; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; cholinergic; cholinergic neuron; cognitive dysfunction; cognitive loss; cognitively impaired; corticotropin-releasing factor receptor 1; dementia of the Alzheimer type; dementia praecox; disease/disorder; endothelial cell derived relaxing factor; guanosine 3'5' monophosphate; guanylyl cyclase; imaging; innervation; mental illness; nerve supply; neural; neuronal; normal aging; pathway; phosphoric diester hydrolase; prevent; preventing; primary degenerative dementia; programs; psychological disorder; recruit; relating to nervous system; schizophrenic; senile dementia of the Alzheimer type; septohippocampal; social role",Cholinergic and GABAergic Mechanisms in the Septohippocampal Pathway,,61465,MNPS,Molecular Neuropharmacology and Signaling Study Section,,10,300222,
7787442,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH062527-08,,NIMH:386250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"MARKOU, ATHINA ;",1895483;,5R01MH062527,12/01/2000,01/31/2014,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 1-(1-Phenylcyclohexyl)piperidine; 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-; 5HT; Abbreviations; Acetylcholine; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Affect; Affinity; Aminalon; Aminalone; Angel Dust; Animal Model; Animal Models and Related Studies; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Attention; Attenuated; Behavioral; Brain; Butanoic acid, 4-amino-; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chronic; Clozapine; Coenzyme II; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive Manifestations; Cognitive Symptoms; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Common Rat Strains; Communities; Cues; Development; Dialysis; Dialysis procedure; Disease; Disorder; Disturbance in cognition; Drugs; Encephalon; Encephalons; Enteramine; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Exhibits; Functional impairment; GABA; Glutamates; HPLC; High Pressure Liquid Chromatography; Hippophaine; Human; Human, General; Impaired cognition; L-Glutamate; Levarterenol; Levonorepinephrine; Literature; Location; Major Tranquilizers; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Mediating; Medical; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental disorders; Mental health disorders; Metabotropic Glutamate Receptors; Methods; Methods and Techniques; Methods, Other; Microdialysis; Modeling; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Transmitter Substances; Nervous; Nervous System, Brain; Neurobehavioral Manifestations; Neurobiology; Neurochemistry; Neurocognition; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neuromediator Receptors; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Nicotinamide-Adenine Dinucleotide Phosphate; Noradrenaline; Norepinephrine; Nucleus Accumbens; Oxidases; Pathology; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Phencyclidine; Population; Prefrontal Cortex; Prevention; Problem Solving; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychiatric Disease; Psychiatric Disorder; Rat; Rattus; Reaction Time; Receptor Protein; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Receptors, Neurohumor; Regimen; Research; Research Design; Response RT; Response Time; Reversal Learning; Role; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Self Stimulation; Serotonin; Short-Term Memory; Signs and Symptoms, Neurobehavioral; Site; Societies; Study Type; Symptoms; System; System, LOINC Axis 4; Techniques; Tranquilizing Agents, Major; Triphosphopyridine Nucleotide; Unspecified Mental Disorder; Work; atypical antipsychotic; base; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cost; dementia praecox; dialysis therapy; disease/disorder; drug/agent; experiment; experimental research; experimental study; flexibility; functional disability; gamma-Aminobutyric Acid; glycine transporter; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; mental illness; model organism; monoamine; multidisciplinary; neural; neural mechanism; neurobiological; neurochemistry; neuromechanism; neuropathology; new therapeutic target; novel; phencyclidine intoxication; prevent; preventing; processing speed; programs; psychological disorder; psychomotor reaction time; quetiapine; receptor; relating to nervous system; research study; response; schizophrenic; social role; study design; subcutaneous; vigilance; working memory",Negative Symptoms of Schizophrenia: Animal Models," Narrative Schizophrenia is a chronic mental illness that results in tremendous human suffering and monetary costs to society. Cognitive impairments are core symptoms of schizophrenia that are not adequately treated by available medications and greatly contribute to profound functional impairment. The results of the proposed studies will promote our understanding of the neurobiology of cognitive deficits in schizophrenia, will elucidate specific neurotransmitter actions of atypical antipsychotics that may mediate their differential effects on various cognitive domains, and finally aid in the discovery of novel therapeutic targets for these poorly treated cognitive deficits.",62527,NMB,Neurobiology of Motivated Behavior Study Section,,8,386250,
7787532,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH062646-11,,NIMH:316729;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CONN, P JEFFREY;",1886557;,5R01MH062646,02/15/2001,01/31/2011,"Address; Affinity; Agonist; Animal Model; Animal Models and Related Studies; Animals; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Astrocytes; Astrocytus; Astroglia; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Blood - brain barrier anatomy; Blood Coagulation Factor IV; Blood-Brain Barrier; Brain; Ca++ element; Calcium; Cell Communication and Signaling; Cell Signaling; Cells; Chemosensitization; Chemosensitization/Potentiation; Coagulation Factor IV; Cognition; Combining Site; Common Rat Strains; Coupling; Data; Development; Encephalon; Encephalons; Environment; Factor IV; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Genetic Alteration; Genetic Change; Genetic defect; Glutamates; Half-Life; Half-Lifes; Hemato-Encephalic Barrier; Image; Intracellular Communication and Signaling; Investigators; L-Glutamate; Macromolecular Structure; Major Tranquilizers; Mammals, Mice; Mammals, Rats; Mediating; Metabotropic Glutamate Receptors; Mice; Modeling; Molecular; Molecular Interaction; Molecular Structure; Murine; Mus; Mutagenesis, Site-Directed; Mutation; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neurologic Disorders; Neurological Disorders; Neurons; Physiologic; Physiological; Population; Potentiation; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Rat; Rattus; Reactive Site; Receptor Activation; Receptor Protein; Receptors, Metabotropic Glutamate; Regulation; Research Personnel; Researchers; Rodent Model; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Slice; Synapses; Synaptic; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Testing; Therapeutic; Therapeutic Agents; Thinking; Thinking, function; Tranquilizing Agents, Major; analog; base; biological signal transduction; cognitive function; genome mutation; imaging; in vivo; model organism; nervous system disorder; neurological disease; neuronal; new approaches; novel; novel approaches; novel strategies; novel strategy; patch clamp; programs; receptor; receptor coupling; response; theories; treatment strategy",Regulation of Signaling by mGluR5,,62646,MNPS,Molecular Neuropharmacology and Signaling Study Section,,11,316729,
7772385,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH063232-10,,NIMH:316729;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"COLBRAN, ROGER J;",1869960;,5R01MH063232,05/15/2001,01/31/2011,"Abscission; Actinin; Actins; Acute; Affinity; Alleles; Allelomorphs; Ammon Horn; Binding; Binding (Molecular Function); Biochemical; Blood Coagulation Factor IV; Body Tissues; Brain; Brain Diseases; Brain Disorders; CRE Recombinase; Ca++ element; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium; Calcium Ion Signaling; Calcium Signaling; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium/calmodulin-dependent protein kinase; Calmodulin; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cellular Matrix; Cellular Morphology; Coagulation Factor IV; Complex; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Cre recombinase, Enterobacteria phage P1; Cytoskeletal System; Cytoskeleton; DLG1; DLG1 gene; Data; Depression; Development; EC 2.7; Encephalon; Encephalon Diseases; Encephalons; Enterobacteria phage P1 Cre recombinase; Epilepsy; Epileptic Seizures; Epileptics; Excision; Extirpation; Factor IV; Feedback; Funding; Glutamate Receptor; Goals; HDLG; Hippocampus; Hippocampus (Brain); Holoenzymes; Idiopathic Parkinson Disease; Immunologic Techniques; Immunological Technics; Immunological Techniques; In Vitro; Intracellular Communication and Signaling; Intracellular Second Messengers; Intracellular Structure; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Kinases; Knock-out; Knockout; Knockout Mice; Knowledge; LRR; Laboratories; Learning; Leucine-Rich Repeat; Lewy Body Parkinson Disease; Link; Mammals, Mice; Memory; Mental Depression; Messenger RNA; Mice; Mice, Knock-out; Mice, Knockout; Microscopic; Modeling; Molecular; Molecular Interaction; Murine; Mus; Mutate; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NR1; NR1 gene; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Null Mouse; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Peptide Domain; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Primary Parkinsonism; Property; Property, LOINC Axis 2; Protein Domains; Protein Phosphorylation; Proteins; RNA Splicing; RNA, Messenger; Receptors, N-Methylaspartate; Receptors, Neurohumor; Recombinants; Regulation; Removal; Right-Handed Beta-Alpha Superhelix; Role; SAP97; Schizophrenia; Schizophrenic Disorders; Second Messenger Systems; Second Messengers; Seizure Disorder; Shapes; Sialoglycoproteins; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slice; Splicing; Striate Body; Striatum; Subcellular structure; Surface; Surgical Removal; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Technics, Immunologic; Tertiary Protein Structure; Testing; Therapeutic Intervention; Tissues; Translations; Transphosphorylases; Variant; Variation; Work; addiction; bacteriophage P1 recombinase Cre; biological signal transduction; biological systems; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; cartilage link protein; cell morphology; cross-link; crosslink; dementia praecox; densin-180; density; desensitization; epilepsia; epileptiform; epileptogenic; gene product; hippocampal; improved; insight; intervention therapy; intracellular skeleton; link protein; mRNA; microtubule associated protein 2 kinase; nervous system disorder; neurological disease; neuron development; neuronal; novel; postsynaptic; protein complex; protein kinase II; resection; schizophrenic; second messenger; social role; striatal; therapeutic target; trafficking; treatment strategy",Mechanisms of CaM Kinase II signal Transduction,,63232,MNPS,Molecular Neuropharmacology and Signaling Study Section,,10,316729,
7768490,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH064043-08,,NIMH:350437;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PRINCETON,UNITED STATES,PSYCHOLOGY,12,002484665,US,NJ,085440036,PRINCETON UNIVERSITY,"KASTNER, SABINE ;",6729791;,5R01MH064043,07/01/2001,12/31/2012,"AD/HD; ADHD; Apoplexy; Architecture; Area; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Attentional deficit; Behavior; Brain; Brain imaging; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cognitive; Computer Architectures; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Engineering / Architecture; Environment; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Human; Human, General; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Individual; Intracellular Communication and Signaling; Laboratories; Lateral Geniculate Body; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Mammals, Primates; Man (Taxonomy); Man, Modern; Mediating; Methods; Monkeys; Nervous; Nervous System, Brain; Neurophysiology / Electrophysiology; Parietal; Physiology; Primates; Process; Programs (PT); Programs [Publication Type]; Research; Resolution; Schizophrenia; Schizophrenic Disorders; Selective inattention; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stroke; Vascular Accident, Brain; Visual; Visual Cortex; Visual System; Visual attention; Visual system structure; Work; attention deficit hyperactive disorder; attentional modulation; base; behavior measurement; behavioral measure; behavioral measurement; biological signal transduction; brain attack; brain visualization; cerebral vascular accident; dementia praecox; effective therapy; fMRI; imaging modality; innovate; innovation; innovative; lateral geniculate; lateral geniculate nucleus; magnocellular; network architecture; neural; neural mechanism; neuromechanism; parvocellular; perceptual organization; programs; relating to nervous system; schizophrenic; selective attention; stroke; theories; treatment strategy; visual cortical",Neural basis of Visual Attention,,64043,CP,Cognition and Perception Study Section,,8,350437,
7778186,R01,MH,5,,01/01/2010,12/31/2010,PA-07-092,5R01MH064541-07,,NIMH:355500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,OAKLAND,UNITED STATES,,09,150829349,US,CA,94612,KAISER FOUNDATION RESEARCH INSTITUTE,"CLARKE, GREGORY N;",1878188;,5R01MH064541,12/01/2001,12/31/2012,"0-11 years old; 12-20 years old; 17 year old; 5HT transporter; 5HTT protein; Absenteeism; Active Follow-up; Acute; Address; Adolescence; Adolescent; Adolescent Youth; Adoption; Affective Disorders; Age; Age of Onset; Angiotensins; Anxiety; Area; BMI percentile; BMI z-score; Behavioral; Benchmarking; Best Practice Analysis; Biological; Blood Pressure, High; Blood Pressure, Low; Body mass index; Boston; Candidate Disease Gene; Candidate Gene; Child; Child Abuse; Child Youth; Childhood Abuse; Children (0-21); Chronic; City of Boston; Cognitive; Competence; Costs and Benefits; DNA; Data; Data Collection; Data Coordinating Center; Data Coordination Center; Deoxyribonucleic Acid; Depressed mood; Depression; Depression, Unipolar; Depressive disorder; Development; Diet; Disease; Disorder; Divorce; Doctor of Philosophy; Early Diagnosis; Economics; Education; Educational aspects; Effectiveness of Interventions; Effects, Longterm; Emotional Depression; Employment; Enrollment; Environment; Environmental Factor; Environmental Risk Factor; Enzymes; Epidemiology, Family Medical History; Evaluation; Event; Family; Family Medical History; Family history of; Family member; Foundations; Funding; Future; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Risk; Genetic analyses; Goals; Health; Health Benefit; Health Care Costs; Health Costs; Health Psychology; Health Status; Healthcare Costs; History; Hostility; Human, Child; Hypertension; Hypotension; Impairment; Incidence; Individual; Individual Differences; Intervention; Intervention Strategies; Intervention Studies; Interview; Job Environment; Job Location; Job Place; Job Setting; Job Site; Knowledge; Lead; Level of Health; Life; Link; Literature; Long-Term Effects; Longitudinal Studies; Measures; Mediating; Medical; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; Modeling; Molecular; Mood Disorders; Morbidity; Morbidity - disease rate; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neuroses; Neurosis, Depressive; Neurotic Disorders; Occupational; Outcome; Over weight; Overweight; Parents; Participant; Patient Self-Report; Pb element; Personality; Ph.D.; PhD; Phone; Physical activity; Polymorphism (Genetics); Polymorphism, Genetic; Population; Prevalence; Prevention; Prevention program; Prevention strategy; Preventive; Preventive Intervention; Preventive strategy; Procedures; Productivity; Program Development; Programs (PT); Programs [Publication Type]; Progress Reports; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psyche structure; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychology, Health; Psychoneuroses; Psychopathology; Psychosocial Factor; Public Health; Quetelet index; R01 Mechanism; R01 Program; RPG; Randomized; Recording of previous events; Recurrence; Recurrent; Relative; Relative (related person); Relative Risks; Reporting; Reports, Progress; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Risk; Risk Behaviors; Risk Factors; Risks, Relative; Risky Behavior; Role; SUBGP; Sample Size; Sampling; Schools; Self-Report; Severities; Site; Sleep; Smoking; Social Policies; Source; Specific qualifier value; Specified; Stress; Subgroup; Substance abuse problem; Suicide; Symptoms of depression; Teen; Teenagers; Teens; Telephone; Training; Unemployment; Unipolar Depression; United States National Institute of Mental Health; Universities; Unspecified Mental Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; Youth; Youth 10-21; abnormal psychology; abuse neglect; abuse of substances; adolescence (12-20); adolescent trauma; adult youth; at risk behavior; cardiovascular disease risk; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; childhood trauma; children; cohort; cost; cost effectiveness; critical period; depressed; depressive; depressive symptoms; design; designing; disability; disease prevention; disease/disorder; disorder prevention; early childhood; early detection; economic impact; economic outcome; effect of intervention; emerging adult; emerging adulthood; enroll; environmental risk; experience; fatal attempt; fatal suicide; follow-up; genetic analysis; health care organization; health care service organization; heavy metal Pb; heavy metal lead; high risk; human capital; hyperpiesia; hyperpiesis; hypertensive disease; improved; indexing; innovate; innovation; innovative; intent to die; intervention development; intervention effect; intervention program; interventional strategy; jobless; joblessness; juvenile; juvenile human; long-term study; meetings; mental; mental illness; multi-site trial; neglect and abuse; neurotic; neuroticism; next generation; novel; offspring; out of work; pediatric trauma; performance site; physical conditioning; polymorphism; prevent; preventing; preventional intervention strategy; proband; programs; psychologic; psychological; psychological disorder; psychosocial; psychosocial variables; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; response; sadness; serotonin transporter; service intervention; seventeen year old; social role; sodium-dependent serotonin transporter; stressor; substance abuse; suicidal risk; suicidality; suicide risk; teen years; teenage; therapy development; trait; treatment as usual; treatment development; treatment effect; unemployed; work environment; work setting; young adult; youngster",4/4-Prevention of Depression: Impact on Transition to Early Adulthood," 7. Project Narrative In our original study, we found that we can prevent depression among at-risk youth, but we do not yet know if this prevention lasts and whether it improves youths' schooling, employment, and relationships with others. The proposed study will be the first to examine whether depression continues to be prevented as these teens become young adults. This study also will identify youth who are most likely to benefit from this program, and will inform us about how to create future prevention programs that help those youth who did not benefit.",64541,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,7,355500,
7753913,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH064700-07,,NIMH:328338;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,FORT COLLINS,UNITED STATES,VETERINARY SCIENCES,04,785979618,US,CO,80523,COLORADO STATE UNIVERSITY-FORT COLLINS,"PARTIN, KATHRYN MCKAY;",1905011;,5R01MH064700,09/21/2001,12/31/2012,"AD/HD; ADHD; AMPA Receptors; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Binding Sites; Biotinylation; Cell Communication and Signaling; Cell Signaling; Cleaved cell; Clinical; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Combining Site; Computer Simulation; Computerized Models; Country; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; Disease; Disorder; Disturbance in cognition; Drug usage; Drugs; Electrophysiology; Electrophysiology (science); Energy Transfer; Fluorescence; Future; Gelineau Syndrome; Genetic Alteration; Genetic Change; Genetic defect; Glutamate Receptor; Glutamates; Goals; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Idiopathic Parkinson Disease; Impaired cognition; Individual; Intracellular Communication and Signaling; Kanner's Syndrome; L-Glutamate; Lewy Body Parkinson Disease; Ligand Binding; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Mental Depression; Mental disorders; Mental health disorders; Metabolic; Method LOINC Axis 6; Methodology; Models, Computer; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Mutation; Narcolepsy; Narcoleptic Syndrome; Neurologic; Neurological; Neurophysiology / Electrophysiology; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Paroxysmal Sleep; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Primary Parkinsonism; Primary Senile Degenerative Dementia; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Progressive Disease; Proteins; Psychiatric Disease; Psychiatric Disorder; Pyrrolidinones; Pyrrolidones; QOL; Quality of life; Reactive Site; Receptor Protein; Receptors, AMPA; Schizophrenia; Schizophrenic Disorders; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Symptoms; Unspecified Mental Disorder; attention deficit hyperactive disorder; biological signal transduction; cleaved; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; dementia of the Alzheimer type; dementia praecox; desensitization; design; designing; disease/disorder; drug use; drug/agent; gene product; genome mutation; improved; in silico; mental illness; mild cognitive disorder; mild cognitive impairment; mild neurocognitive disorder; patch clamp; primary degenerative dementia; programs; protein complex; psychological disorder; public health relevance; receptor; schizophrenic; senile dementia of the Alzheimer type; stargazin; structural biology; tool; virtual simulation",GLUTAMATE RECEPTOR DESENSITIZATION AND ITS MODULATION," Reduced glutamatergic signaling is a final common denominator of a number of disorders that reduce cognitive ability, including mild cognitive impairment, Alzheimer's disease, schizophrenia, ADHD, narcolepsy, autism, depression, schizophrenia and Parkinson's disease. AMPA receptor modulators show promise in the treatment of diseases resulting in the loss of cognitive function. A biophysical approach to study modulation of deactivation and desensitization using drugs that have intrinsically different modes of action may better direct future efforts to design AMPA-selective, cognition-enhancing drugs.",64700,MNPS,Molecular Neuropharmacology and Signaling Study Section,,7,328338,
7778184,R01,MH,5,,01/01/2010,12/31/2010,PA-07-092,5R01MH064735-06,,NIMH:387500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,SOCIAL SCIENCES,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"GARBER, JUDY ;",6066589;,5R01MH064735,12/01/2001,12/31/2012,"0-11 years old; 12-20 years old; 17 year old; 5HT transporter; 5HTT protein; Absenteeism; Active Follow-up; Acute; Address; Adolescence; Adolescent; Adolescent Youth; Adoption; Affective Disorders; Age; Age of Onset; Angiotensins; Anxiety; Area; BMI percentile; BMI z-score; Behavioral; Benchmarking; Best Practice Analysis; Biological; Blood Pressure, High; Blood Pressure, Low; Body mass index; Boston; Candidate Disease Gene; Candidate Gene; Child; Child Abuse; Child Youth; Childhood Abuse; Children (0-21); Chronic; City of Boston; Cognitive; Competence; Costs and Benefits; DNA; Data; Data Collection; Data Coordinating Center; Data Coordination Center; Deoxyribonucleic Acid; Depressed mood; Depression; Depression, Unipolar; Depressive disorder; Development; Diet; Disease; Disorder; Divorce; Doctor of Philosophy; Early Diagnosis; Economics; Education; Educational aspects; Effectiveness of Interventions; Effects, Longterm; Emotional Depression; Employment; Enrollment; Environment; Environmental Factor; Environmental Risk Factor; Enzymes; Epidemiology, Family Medical History; Evaluation; Event; Family; Family Medical History; Family history of; Family member; Foundations; Funding; Future; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Risk; Genetic analyses; Goals; Health; Health Benefit; Health Care Costs; Health Costs; Health Psychology; Health Status; Healthcare Costs; History; Hostility; Human, Child; Hypertension; Hypotension; Impairment; Incidence; Individual; Individual Differences; Intervention; Intervention Strategies; Intervention Studies; Interview; Job Environment; Job Location; Job Place; Job Setting; Job Site; Knowledge; Lead; Level of Health; Life; Link; Literature; Long-Term Effects; Longitudinal Studies; Measures; Mediating; Medical; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; Modeling; Molecular; Mood Disorders; Morbidity; Morbidity - disease rate; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neuroses; Neurosis, Depressive; Neurotic Disorders; Occupational; Outcome; Over weight; Overweight; Parents; Participant; Patient Self-Report; Pb element; Personality; Ph.D.; PhD; Phone; Physical activity; Polymorphism (Genetics); Polymorphism, Genetic; Population; Prevalence; Prevention; Prevention program; Prevention strategy; Preventive; Preventive Intervention; Preventive strategy; Procedures; Productivity; Program Development; Programs (PT); Programs [Publication Type]; Progress Reports; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psyche structure; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychology, Health; Psychoneuroses; Psychopathology; Psychosocial Factor; Public Health; Quetelet index; R01 Mechanism; R01 Program; RPG; Randomized; Recording of previous events; Recurrence; Recurrent; Relative; Relative (related person); Relative Risks; Reporting; Reports, Progress; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Risk; Risk Behaviors; Risk Factors; Risks, Relative; Risky Behavior; Role; SUBGP; Sample Size; Sampling; Schools; Self-Report; Severities; Site; Sleep; Smoking; Social Policies; Source; Specific qualifier value; Specified; Stress; Subgroup; Substance abuse problem; Suicide; Symptoms of depression; Teen; Teenagers; Teens; Telephone; Training; Unemployment; Unipolar Depression; United States National Institute of Mental Health; Universities; Unspecified Mental Disorder; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; Youth; Youth 10-21; abnormal psychology; abuse neglect; abuse of substances; adolescence (12-20); adolescent trauma; adult youth; at risk behavior; cardiovascular disease risk; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; childhood trauma; children; cohort; cost; cost effectiveness; critical period; depressed; depressive; depressive symptoms; design; designing; disability; disease prevention; disease/disorder; disorder prevention; early childhood; early detection; economic impact; economic outcome; effect of intervention; emerging adult; emerging adulthood; enroll; environmental risk; experience; fatal attempt; fatal suicide; follow-up; genetic analysis; health care organization; health care service organization; heavy metal Pb; heavy metal lead; high risk; human capital; hyperpiesia; hyperpiesis; hypertensive disease; improved; indexing; innovate; innovation; innovative; intent to die; intervention development; intervention effect; intervention program; interventional strategy; jobless; joblessness; juvenile; juvenile human; long-term study; meetings; mental; mental illness; multi-site trial; neglect and abuse; neurotic; neuroticism; next generation; novel; offspring; out of work; pediatric trauma; performance site; physical conditioning; polymorphism; prevent; preventing; preventional intervention strategy; proband; programs; psychologic; psychological; psychological disorder; psychosocial; psychosocial variables; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; response; sadness; serotonin transporter; service intervention; seventeen year old; social role; sodium-dependent serotonin transporter; stressor; substance abuse; suicidal risk; suicidality; suicide risk; teen years; teenage; therapy development; trait; treatment as usual; treatment development; treatment effect; unemployed; work environment; work setting; young adult; youngster",1/4-Prevention of Depression: Impact on the Transition to Early Adulthood," 7. Project Narrative In our original study, we found that we can prevent depression among at-risk youth, but we do not yet know if this prevention lasts and whether it improves youths' schooling, employment, and relationships with others. The proposed study will be the first to examine whether depression continues to be prevented as these teens become young adults. This study also will identify youth who are most likely to benefit from this program, and will inform us about how to create future prevention programs that help those youth who did not benefit.",64735,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,6,387500,
7775034,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH064821-06,,NIMH:419553;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAINT LOUIS,UNITED STATES,PSYCHIATRY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SHELINE, YVETTE I;",1864636;,5R01MH064821,12/01/2001,01/31/2013,"Affect; Affective; After Care; After-Treatment; Aftercare; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Anxiety; Applications Grants; Behavior Therapy, Cognitive; Behavioral Therapy; Brain; Brain region; Cognitive; Cognitive Therapy; Conflict; Conflict (Psychology); Data; Depressed mood; Depression; Dorsal; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Dysfunction; Emotional; Emotions; Encephalon; Encephalons; Escitalopram; FLR; Failure (biologic function); Fear; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Grant Proposals; Grants, Applications; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Impairment; Individual; Laboratories; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Major Depressive Disorder; Medial; Medication; Mental Depression; Methods; Middle Frontal Gyrus; Middle frontal gyrus structure; Modeling; Motor Cortex; Nervous System, Brain; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Prefrontal Cortex; Process; Progress Reports; Psychotherapy, Cognitive; Randomized; Recurrence; Recurrent; Regulation; Reports, Progress; Research; Rest; Site; Source; Stimulus; Structure; System; System, LOINC Axis 4; Testing; Therapeutic Effect; Therapy, Cognition; Visual; Work; amygdaloid nuclear complex; base; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; cognitive control; cognitive function; comparative; depressed; design; designing; drug/agent; emotion regulation; emotional reaction; experiment; experimental research; experimental study; fMRI; failure; major depression; mood regulation; novel; pathophysiology; public health relevance; randomisation; randomization; randomly assigned; research study; sadness",FMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION, Project Narrative In this project we will conduct functional magnetic resonance imaging studies in 60 depressed patients and 30 matched comparison subjects. We will examine changes in brain regions following cognitive behavioral therapy (CBT) or antidepressant treatment during three different conditions. One is an emotionally negative conflict task. The second is a task in which people regulate their emotional reaction to negative pictures. The third is during the resting state. Brain activity will be compared before and after treatment for these tasks in both CBT and antidepressant medication. This will add to our understanding of treatment mechanisms for major depression.,64821,ZRG1,Special Emphasis Panel,,6,419553,
7770841,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH065252-09,,NIMH:347581;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CAMBRIDGE,UNITED STATES,OTHER BASIC SCIENCES,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"MILLER, EARL K;",1912978;,5R01MH065252,04/01/2002,01/31/2012,"Address; Advocate; Area; Artifacts; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Paradigm; Behavioral Therapy; Behavioral Treatment; Brain; Categories; Cognition; Cognitive; Conditioning Therapy; Data; Disease; Disorder; Dorsal; Drugs; Dysfunction; Educational process of instructing; Electrodes; Electrodes, Miniaturized; Employee Strikes; Encephalon; Encephalons; Fingers; Foundations; Functional disorder; Funding; General Practitioners; Generalists; Goals; Human; Human, General; Implant; Inferior; Investigators; Kanner's Syndrome; Lateral; Learning; Life Style Modification; Link; Man (Taxonomy); Man, Modern; Medication; Microelectrodes; Modeling; Monkeys; Morphologic artifacts; Motor; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Parietal Lobe; Parietal Lobe of the Brain; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Population; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Research Personnel; Researchers; Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Sensory; Shapes; Slice; Specialist; Specificity; Stimulus; Strikes; Strikes, Employee; Structure; Survey Instrument; Surveys; Teaching; Temporal Lobe; Testing; Training; Visual; abstracting; base; behavior intervention; behavioral intervention; cognitive function; dementia praecox; disease/disorder; drug/agent; experience; extrastriate visual cortex; flexibility; meetings; neural; neuronal; neurophysiology; neuropsychiatric; neuropsychiatry; novel; parietal cortex; pathophysiology; programs; relating to nervous system; schizophrenic; sensory cortex; temporal cortex; temporal lobe/cortex; theories; tool",Neural Basis of Categories,,65252,ZRG1,Special Emphasis Panel,,9,347581,
7782827,R01,MH,5,,02/01/2010,01/31/2011,PA-07-083,5R01MH068791-07,,NIMH:396000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ATLANTA,UNITED STATES,BIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"PARR, LISA A.;",2242521;,5R01MH068791,09/01/2003,01/31/2014,"3D image; Accounting; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Apes; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Back; Behavior; Behavioral; Biology; Brain region; Buccal Cavity; Categories; Cavitas Oris; Chimp; Chimpanzee; Cognitive; Cognitive Discrimination; Comparative Study; Complex; Computers; Conflict; Conflict (Psychology); Cues; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Diagnostic; Discrimination; Discrimination (Psychology); Disease; Disorder; Dorsum; Emotional; Evolution; Eye; Eyeball; Face; Face Expression Recognition; Face Processing; Facial Expression; Facial Expression Recognition; Gender Identity; Goals; Head; Head and Neck, Buccal Cavity; Human; Human, General; Images, 3-D; Individual; Kanner's Syndrome; Life Stress; Macaca mulatta; Mammals, Primates; Man (Taxonomy); Man, Modern; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Monkeys; Mouth; Nasal; Nervous; Neurobiology; Neuropsychologies; Neuropsychology; Nose; Nose, Nasal Passages; Oral cavity; Paired Comparison; Pan; Pan Genus; Pan Species; Perception; Performance; Phenotype; Pongidae; Primary Senile Degenerative Dementia; Primates; Procedures; Process; Progress Reports; Reading; Reporting; Reports, Progress; Research; Respiratory System, Nose, Nasal Passages; Rhesus; Rhesus Macaque; Rhesus Monkey; Sampling; Seminal; Series; Social Perception; Stimulus; Study models; System; System, LOINC Axis 4; Techniques; Testing; Three-Dimensional Image; Visual; base; cognitive system; comparative; dementia of the Alzheimer type; disease/disorder; experiment; experimental research; experimental study; face expression; facial; flexibility; gaze; great ape; human disease; information processing; neural; neurobiological; neuroimaging; neuropsychologic; neuropsychological; non-human primate; nonhuman primate; primary degenerative dementia; public health relevance; relating to nervous system; research study; senile dementia of the Alzheimer type; skills; social cognition; visual process; visual processing",Behavioral and neural processing of faces and expressions in nonhuman primates," Project Narrative Among humans, there are numerous disorders that include deficits of social cognition, such as face recognition and/or producing and responding to facial expressions. In order to better understand these disorders, nonhuman primates are often used as models for the human condition. However, extremely little is known about the basic behavior and biology of socio-cognitive processes in nonhuman primates. Therefore, it is the goal of these studies to compare directly the ability of monkeys and apes to process facial stimuli in order to better understand and treat human diseases.",68791,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,7,396000,
7762781,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH069119-05,,NIMH:393583;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"CHOI, KYUNG-HEE ;",2692257;,5R01MH069119,02/03/2005,01/31/2011,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; African American; Afro American; Afroamerican; Age; Anal; Anus; Asians; Black Populations; Black or African American; Characteristics; Color; Computer Assisted; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Discrimination, Social; Disease Frequency Surveys; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Ethnography; Exhibits; Focus Groups; Glossary; HIV; HIV Infections; HIV Prevention; HIV Seroprevalence; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hand; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Intervention; Intervention Strategies; Interview; Investigators; Knowledge; LAV-HTLV-III; Latino; Link; Literature; Los Angeles; Lymphadenopathy-Associated Virus; Maps; Measures; Modeling; Nature; Orientation, Sexual; Pacific Island Americans; Pacific Islander; Pacific Islander American; Pathway interactions; Pattern; Persons; Phase; Poverty; Prevalence; Prevention Research; Prevention strategy; Preventive strategy; Process; Programs (PT); Programs [Publication Type]; Questionnaires; Race; Racial Group; Reader; Reporting; Research; Research Personnel; Researchers; Respondent; Risk; Risk Behaviors; Risky Behavior; STD; Sampling; Sex Orientation; Sexual Partners; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Social Discrimination; Social Network; Societal Factors; Socio-economic status; Socioeconomic Status; Specific qualifier value; Specified; Status, Socioeconomic; Stocks, Racial; Survey Instrument; Surveys; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Validity and Reliability; Variant; Variation; Venereal Diseases; Venereal Disorders; Venereal Infections; Virus-HIV; Work; acronyms; at risk behavior; base; black American; computer aided; demographics; ethnic difference; ethnic minority; ethnic minority population; ethnographic; insight; interest; interventional strategy; meetings; member; men; men who have sex with men; men who have sex with other men; men's; next generation; oriental; pathway; programs; racism; sex partner; sex risk; social",Social/Sexual Networks & HIV Risk: Men of Color,,69119,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,5,393583,
7771726,R01,MH,5,,02/01/2010,01/31/2011,PAR-06-039,5R01MH069806-04,,NIMH:286931;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,AURORA,UNITED STATES,FAMILY MEDICINE,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"WEST, DAVID R.;",8485495;,5R01MH069806,02/01/2007,01/31/2011,"Acute; Address; Adopted; Adoption; Affect; Arm; Assessment, Process; Attention; Belief; Care, Health; Care, Managed; Caring; Ch'i; Characteristics; Chronic; Chronic Care; Chronic Disease; Chronic Illness; Chronic depressive disorder; Chronic depressive personality disorder; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Communities; Data; Depression; Detection; Development; Diabetes Mellitus; Disease; Disorder; Effectiveness; Emotional; Environment; Feedback; Guidelines; Healthcare; Human Resources; Individual; Intention; Intervention; Intervention Strategies; Interview; Investigators; Lead; Life-Breath (Philosophy); Major Depressive Disorder; Managed Care; Manpower; Measurement; Measures; Medical; Mental Depression; Mental Health; Mental Hygiene; Methods; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motivation; Nature; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Outcome; Patient Care; Patient Care Delivery; Patients; Pb element; Physicians; Populations at Risk; Preventive; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Procedures; Process; Process Assessment (Health Care); Programs (PT); Programs [Publication Type]; Psychological Health; QOC; Qi; Qualitative Methods; Quality of Care; Randomized; Recruitment Activity; Relative; Relative (related person); Research Personnel; Research Resources; Researchers; Resources; Self Management; Services; Sound; Sound - physical agent; Stress; Structure; Surgical; Surgical Interventions; Surgical Procedure; Survey Instrument; Surveys; System; System, LOINC Axis 4; Testing; Time; Upper arm; Vital Energy (Philosophy); Work; base; care systems; chronic care model; chronic depression; chronic disease/disorder; chronic disorder; clinical investigation; design; designing; diabetes; disease/disorder; evidence base; flexibility; heavy metal Pb; heavy metal lead; improved; information processing; innovate; innovation; innovative; intervention effect; interventional strategy; major depression; patient centered; patient oriented; personnel; population based; prevent; preventing; programs; prospective; randomisation; randomization; randomized trial; randomly assigned; recruit; sound; success; surgery; systems of care; tool; treatment as usual",Practice Redesign to Improve Depression Care - PRIDE Care,,69806,SRNS,Mental Health Services in Non-Specialty Settings,,4,286931,
7799920,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH069893-05,,NIMH:368750;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LINCOLN,UNITED STATES,BIOLOGY,01,555456995,US,NE,685880430,UNIVERSITY OF NEBRASKA LINCOLN,"BOND, ALAN BRANDON;",9081585;,5R01MH069893,09/01/2003,01/31/2013,"Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; American; Ammon Horn; Amnesia; Amnesia-Memory Loss; Animals; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Aves; Avian; Baboons; Basil; Behavioral; Biological Models; Birds; Categories; Characteristics, Social; Cognition; Cognition Disorders; Cognitive; Complex; Cornu Ammonis; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Development; Diagnosis; Dimensions; Disease; Disorder; Family Relations; Family Relationship; Food; Group Structure; Hierarchy, Social; Hippocampal Formation; Hippocampus; Hippocampus (Brain); History; Human; Human, General; Individual; Intelligence; Investigation; Kanner's Syndrome; Laboratories; Lesion; Life; Man (Taxonomy); Man, Modern; Memory; Mental disorders; Mental health disorders; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Natural History; Nervous; Neurobiology; Ocimum basilicum; Operation; Operative Procedures; Operative Surgical Procedures; Papio; Papios; Patients; Performance; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Recording of previous events; Recovery; Relative; Relative (related person); Research; Role; Savanna Baboons; Schizophrenia; Schizophrenic Disorders; Site; Social Behavior; Social Characteristics; Social Hierarchy; Social Network; Societies; Staging; Stimulus; Structure; Surgical; Surgical Interventions; Surgical Procedure; Sweet Basil; Techniques; Testing; Unspecified Mental Disorder; Update; Work; base; cognitive disease; cognitive disorder; comparative; dementia of the Alzheimer type; dementia praecox; disease/disorder; experiment; experimental research; experimental study; flexibility; hippocampal; insight; interest; member; mental illness; mental representation; neural; neurobiological; primary degenerative dementia; programs; psychological disorder; public health relevance; relating to nervous system; research study; schizophrenic; senile dementia of the Alzheimer type; social; social cognition; social group; social role; sociobehavior; sociobehavioral; surgery",Mechanisms of Social Cognition,"       PROJECT NARRATIVE    A variety of mental disorders, including autism, schizophrenia, and Alzheimer's disease, degrade the patients'  ability to understand and make inferences about social relationships. By integrating operant, observational,  and neurobiological approaches, the proposed research provides a unique opportunity to investigate the  mechanism of social cognition directly and to evaluate the relationship between natural social cognition and  performance on laboratory tests. The methodology will be applicable to the study of transitive inference and  social cognition in humans, providing significant benefits for the diagnosis and treatment of cognitive  disorders.   ",69893,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,5,368750,
7756687,R01,MH,5,,01/01/2010,12/31/2010,,5R01MH070830-05,,NIMH:221470;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,PSYCHIATRY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"KEANE, MARGARET M;",1941676;,5R01MH070830,03/01/2005,12/31/2010,Affect; Amnesia; Amnesia-Memory Loss; Area; Classification; Cognition; Cognitive; Exposure to; Investigation; Investigators; Medial; Mediating; Memory; Nature; Participant; Patients; Performance; Performance Status; Price; Process; Programs (PT); Programs [Publication Type]; Research Personnel; Researchers; Source; Specific qualifier value; Specified; Stimulus; Systematics; Task Performances; Temporal Lobe; Testing; cost; experience; frontal lobe function; implicit memory; memory process; pricing; programs; response; temporal cortex; temporal lobe/cortex; theories,Memory-Induced Performance Costs in Amnesia,,70830,CP,Cognition and Perception Study Section,,5,221470,
7761201,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH071852-05,,NIMH:503147;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOS ANGELES,UNITED STATES,GENETICS,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"NELSON, STANLEY F.;",1875784;,5R01MH071852,02/01/2006,01/31/2011,"0-11 years old; 16p; 17p; AD/HD; ADHD; Accounting; Active Follow-up; Affect; Allele Frequency; Alleles; Allelomorphs; Amino Acids; Area; Assay; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Base Sequence; Behavior; Behavior Disorders; Bioassay; Biologic Assays; Biological Assay; Blood capillaries; Boston; Capillaries; Capillary; Capillary, Unspecified; Child; Child Youth; Childhood; Children (0-21); Chromosome 16 Proximal Arm; Chromosome 16 Short Arm; Chromosome 17 Proximal Arm; Chromosome 17 Short Arm; Chromosome 17p; Chromosome Mapping; City of Boston; Code; Coding System; Collection; Colombia; Criteria, Selection; Custom; DNA; DNA Resequencing; Deoxyribonucleic Acid; Diagnosis; Diagnostic; Diathesis; Disease; Disease susceptibility; Disorder; Environmental Factor; Environmental Risk Factor; Exons; Family; Finland; GWAS; Gene Frequency; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetics, Gene Mapping; Genomics; Genotype; Haplotypes; Heterozygote; Human, Child; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Individual; Investigators; Knowledge; Learning; Life; Link; Linkage Disequilibrium; Linkage Disequilibriums; Linkage Mapping; Los Angeles; Maps; Methods; Molecular; Mutation; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Netherlands; Nonsense Mutation; Nucleotide Sequence; Oligo; Oligonucleotides; Parents; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Predisposition; Process; Programs (PT); Programs [Publication Type]; Promoter Regions; Promoter Regions (Genetics); Promotor Regions; Promotor Regions (Genetics); Public Health; Research Design; Research Personnel; Researchers; Resequencing; Risk; SNP; SNPs; Sample Size; Sampling; School-Age Population; Screening procedure; Selection Criteria; Siblings; Single Nucleotide Polymorphism; Societies; Study Type; Survey Instrument; Surveys; Susceptibility; Testing; Transmission; United States National Institute of Mental Health; Validation; Variant; Variation; Work; allelic frequency; aminoacid; attention deficit hyperactive disorder; base; behavioral disorder; capillary; children; cohort; density; design; designing; disease risk; disease/disorder; disease/disorder proneness/risk; disorder risk; environmental risk; follow-up; genetic mapping; genetic promoter element; genome mutation; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; improved; interest; intervention development; liability to disease; meetings; nucleic acid sequence; pediatric; polymorphism; population based; programs; public health medicine (field); school age; screening; screenings; study design; therapy development; tool; transmission process; treatment development; whole genome association studies; whole genome association study; youngster",SNP studies in ADHD linked regions,,71852,GHD,Genetics of Health and Disease Study Section,,5,503147,
7769454,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH072933-05,,NIMH:306412;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"DASH, PRAMOD K;",1883363;,5R01MH072933,04/01/2006,01/31/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 90-kDa Ribosomal Protein S6 Kinases; Abbreviations; Acquired brain injury; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Age; Agonist; Ammon Horn; Associative Learning; Attention; Band Shift Mobility Assay; Bandshift Mobility Assay; Behavior; Behavioral; Blood Coagulation Factor IV; Blotting, Western; Brain Injuries; CRE; CRE Binding Protein; CREB; CREB Protein; CREB1; CREB1 gene; Ca++ element; Calcium; Causality; Cell Communication and Signaling; Cell Signaling; Coagulation Factor IV; Cognitive; Common Rat Strains; Complex; Conditioned Stimulus; Conditioning, Classical; Conditionings, Classical; Cornu Ammonis; Cyclic AMP Response Element; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic AMP-Responsive DNA-Binding Protein; D1 receptor; Data; Dependency; Dependency (Psychology); Depression; Development; Disease; Disorder; Dopamine; Dopamine Antagonists; Dopamine D1 Receptor; Dopamine Receptor; Dopamine Receptor Antagonists; Dopaminergic Antagonists; Dysfunction; EC 2.7.2-; EMSA; ERK MAP Kinases; Electrophoretic Mobility Shift Assay; Etiology; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Factor IV; Fear; Fright; Functional disorder; Gene Expression; Goals; Hippocampus; Hippocampus (Brain); Hydroxytyramine; Impairment; Information Storage; Infusion; Infusion procedures; Intracellular Communication and Signaling; Investigation; Investigators; Learning; Levarterenol; Levonorepinephrine; MAP kinase; MAP-Kinase-Activated Kinase 1; MAP-Kinase-Activated Protein Kinase 1; MAPK; MAPKAP Kinase-1; MAPKAP-K1; MAPKAPK1; Maintenance; Maintenances; Mammals, Rats; Medial; Memory; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; Mental disorders; Mental health disorders; Methods and Techniques; Methods, Other; Mitogen-Activated Protein Kinases; Mobility Shift Assay; Molecular; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Neocortex; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurons; Noradrenaline; Norepinephrine; PKA; Pavlovian conditioning; Peptide Biosynthesis, Ribosomal; Performance; Pharmacological Treatment; Phase; Phosphorylation; Physiopathology; Play; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase A; Protein Phosphorylation; Protein Synthesis Antagonists; Protein Synthesis Inhibitors; Protein Synthesis, Ribosomal; Psyche structure; Psychiatric Disease; Psychiatric Disorder; Rat; Rattus; Research Personnel; Researchers; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Role; Schizophrenia; Schizophrenic Disorders; Serum Response Factor; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Storage, Data; Structure; Techniques; Testing; Threonine/Tyrosine Protein Kinase; Time; Training; Transcription Factor SRF; Transmission; Unspecified Mental Disorder; Ventral Tegmental Area; Western Blotting; Western Blottings; Western Immunoblotting; base; biological signal transduction; brain damage; brain lesion (from injury); c-fos Serum Response Factor; cAMP Response Element; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; cAMP-Dependent Protein Kinases; classical conditioning; conditioned fear; conditioning; dementia praecox; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; emotional dependency; executive control; executive function; extracellular signal related kinase; fear conditioning; gel shift assay; hippocampal; homotypical cortex; inhibitor; inhibitor/antagonist; insight; isocortex; long term memory; memory process; mental; mental illness; neopallium; nervous system disorder; neurological disease; neuronal; neuropsychiatric; neuropsychiatry; neurotransmitter release; novel; p90 Ribosomal S6 Kinase; p90(rsk); pathophysiology; pp90(rsk); programs; protein blotting; protein synthesis; psychological disorder; response; schizophrenic; social role; transmission process; treatment strategy; ventral tegmentum; working memory",Prefrontal cortex and memory storage,,72933,LAM,Neurobiology of Learning and Memory Study Section,,5,306412,
7796540,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH072935-05,,NIMH:338636;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PSYCHIATRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"CARTER, CAROL SUE;",1878034;,5R01MH072935,04/01/2006,01/31/2011,"21+ years old; Adult; Aggression; Aggressive behavior; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Area; Argipressin; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bed Nucleus of Stria Terminalis; Behavior; Behavioral; Birth; Blood; Brain; Chemotherapy-Hormones/Steroids; Corticosterone; Data; Depression; Development; Emotions; Encephalon; Encephalons; Endocrine; Endocrine Gland Secretion; Exposure to; Fear; Female; Fright; Future; Gender; Gestation; Goals; HPA; Health Benefit; Hormonal Change; Hormones; Human, Adult; Individual Differences; Infant; Kanner's Syndrome; Lactation; Lateral; Mammals, Rodents; Measures; Mediating; Mental Depression; Mental disorders; Mental health disorders; Microdialysis; Microtus; Neglect of Child; Nervous; Nervous System, Brain; Neurobiology; Neuroendocrine; Neuroendocrine System; Neurohormones; Neuropeptides; Neurosecretory Systems; Nucleus Accumbens; OXT; Ocytocin; Oxytocin; Pair Bond; Parenting; Parenting behavior; Partner in relationship; Parturition; Pattern; Peptides; Physiologic; Physiological; Physiology; Play; Postpartum; Postpartum Period; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Pregnancy; Prevention; Process; Psyche structure; Psychiatric Disease; Psychiatric Disorder; Recombinant Oxytocin; Regulation; Research; Reticuloendothelial System, Blood; Rodent; Rodentia; Rodentias; Role; Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Sex Characteristics; Sex Differences; Social Behavior; Social Interaction; Social support; Stimulus; Stress; Stria Terminalis Nucleus; Structure of terminal stria nuclei of preoptic region; Substance abuse problem; System; System, LOINC Axis 4; Testing; Therapeutic Hormone; Time; Unspecified Mental Disorder; Vasopressin, 8-L-arginine-; Vasopressin, Arginine; Vasopressin-Neurophysin II-Copeptin; Vole; abuse of substances; adult human (21+); amygdaloid nuclear complex; base; behavior measurement; behavioral measure; behavioral measurement; child neglect; dementia praecox; experience; field mouse; gender difference; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; immunocytochemistry; interest; male; mate; mental; mental illness; model organism; neural; neurobiological; neurophysiology; novel; physical conditioning; prairie vole; preference; psychological disorder; pup; relating to nervous system; response; schizophrenic; sex dimorphism; sexual dimorphism; sexual dimorphism (noncellular); social; social attachment; social bonding; social role; social support network; sociobehavior; sociobehavioral; stress buffering; stress management; stressor; substance abuse",Neurobiology of Social Support,,72935,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,5,338636,
7760043,R01,MH,5,,02/01/2010,01/31/2011,PA-03-135,5R01MH073019-04,,NIMH:563868;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ROCHESTER,UNITED STATES,PSYCHIATRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"O CONNOR, THOMAS G;",6799204;,5R01MH073019,02/01/2007,01/31/2012,"0-11 years old; 21+ years old; ADRGND; Adrenal Glands; Adrenals; Adult; Aeroseb-HC; Affect; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animals; Anxiety; Area; Behavioral; Biological; Cell Body; Cetacort; Child; Child Development; Child Youth; Children (0-21); Cognitive; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Data; Dermacort; Development; Diagnostic; Discipline of obstetrics; Eldecort; Emotional; Exhibits; Gestation; HPA; Hepatitis B; Hepatitis B Infection; High Prevalence; Human; Human, Adult; Human, Child; Human, General; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; Immune; Immune Function, Cellular; Impairment; Infant; Infant and Child Development; Link; Longitudinal Studies; Man (Taxonomy); Man, Modern; Measures; Mediating; Mental Health; Mental Hygiene; Nature; Nervous System, Pituitary; Nutracort; Obstetrics; Outcome; Parent-Child Relations; Parent-Child Relationship; Parents; Perinatal; Physiologic; Physiological; Pituitary; Pituitary Gland; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Proctocort; Programs (PT); Programs [Publication Type]; Psychological Health; Public Health; Research; Role; Stress; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Testing; Tetanus; Therapeutic Hydrocortisone; Thymus-Dependent Lymphocytes; Translations; Viral Hepatitis B; Woman; Work; adult human (21+); biological adaptation to stress; cell body (neuron); children; clostridial tetanus; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; immune function; in utero; long-term study; maternal stress; meetings; model organism; multidisciplinary; neural cell body; neuronal cell body; offspring; parent child interaction; parent offspring interaction; postnatal; prenatal; prevent; preventing; programs; prospective; psychologic; psychological; public health medicine (field); reaction; crisis; response; serum hepatitis; social role; soma; stress response; stress; reaction; stressed mothers; suprarenal gland; thymus derived lymphocyte; unborn; youngster",Prenatal Anxiety and its Effects on Child Development,,73019,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,4,563868,
7760544,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073080-05,,NIMH:427908;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"BROWN, ALAN STEWART;",1905515;,5R01MH073080,02/16/2006,01/31/2011,"21+ years old; Active Follow-up; Adult; Affective Disorders; Affective Psychosis, Bipolar; Alcohol Drinking; Alcohol consumption; Archives; Area; Assay; BMI percentile; BMI z-score; Bioassay; Biologic Assays; Biological Assay; Bipolar Disorder; Birth; Blood Serum; Body mass index; California; Caring; Causality; Child health care; Cohort Analyses; Cohort Analysis; Cohort Studies; Concurrent Studies; Data; Development; Diagnosis; Disease; Disorder; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; EtOH drinking; Etiology; Fetal Age; Fetal Growth Restriction; Fetal Growth Retardation; Fetal Maturity, Chronologic; Freezing; Gestation; Gestational Age; Grippe; HOSP; Health, Child; Hospitals; Human, Adult; IUGR; Immunologic, Immunochemical; Immunologics; Infection; Influenza; Interview; Intrauterine Growth Retardation; Investigation; Mediating; Medical; Mood Disorders; Parturition; Pathogenesis; Pathway interactions; Perinatal; Perinatal Exposure; Postpartum; Postpartum Period; Predisposition gene; Pregnancy; Prevention strategy; Preventive strategy; Psychosis, Manic-Depressive; Quetelet index; Research; Research Specimen; Risk; Risk Factors; Sampling; Schizophrenia; Schizophrenic Disorders; Serum; Specimen; Structure; Susceptibility Gene; T. gondii infection; Time; Toxoplasma gondii Infection; Toxoplasmosis; adult human (21+); alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; bipolar affective disorder; case control; cohort; cytokine; dementia praecox; design; designing; disease causation; disease etiology; disease risk; disease/disorder; disease/disorder etiology; disorder etiology; disorder risk; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; fetal exposure; flu infection; follow-up; in utero; in utero exposure; influenza infection; intra-uterine environmental exposure; intrauterine environmental exposure; intrauterine growth restriction; manic depressive disorder; manic depressive illness; maternal cigarette smoking; maternal serum; maternal smoking; pathway; predisposing gene; prenatal; prenatal growth disorder; prenatal risk factor; schizophrenic; unborn",Prenatal Factors and Risk of Bipolar Disorder,,73080,ZRG1,Special Emphasis Panel,,5,427908,
7771776,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073156-05,,NIMH:312165;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,BIOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"RICHMOND, JANET E;",3060263;,5R01MH073156,04/01/2006,01/31/2011,"Affect; Aldicarb; Animal Model; Animal Models and Related Studies; Animals; Behavioral; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Biochemical Pathway; Blood Coagulation Factor IV; Body Tissues; Brain; C elegans; C-terminal; C.elegans; Ca++ element; Caenorhabditis elegans; Calcium; Cell membrane; Coagulation Factor IV; Common Rat Strains; Complement; Complement Proteins; Complex; Cytoplasmic Membrane; Cytosol; Data; Deletion Mutation; Disease; Disorder; Encephalon; Encephalons; Event; Exhibits; Exocytosis; Factor IV; Foundations; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic Screening; Genetic analyses; Genetic defect; Goals; Homolog; Homologous Gene; Homologue; Investigators; Isoforms; Knock-out; Knockout; Ligand Binding Protein; Mammals, Rats; Membrane; Membrane Proteins; Membrane-Associated Proteins; Metabolic Networks; Modeling; Models, Genetic; Molecular; Molecular Interaction; Mutation; N-terminal; NH2-terminal; NSF attachment protein receptor; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuronal Transmission; Neurons; Organism; Pattern; Peptide Domain; Phenotype; Plasma Membrane; Process; Propanal, 2-methyl-2-(methylthio)-, O-((methylamino)carbonyl)oxime; Protein Domains; Protein Isoforms; Proteins; RNA Splicing; Rat; Rattus; Regulation; Regulation of Exocytosis; Research Personnel; Researchers; Role; SNAP receptor; SNARE; Series; Splicing; Staging; Structure-Activity Relationship; Surface Proteins; Synapses; Synaptic; Synaptic Transmission; Synaptic Vesicles; Tertiary Protein Structure; Testing; Tissues; Transcript; VESCL; Vesicle; base; chemical structure function; disease/disorder; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; improved; insight; living system; loss of function; membrane structure; model organism; mutant; nervous system disorder; neurological disease; neuronal; neurotransmission; neurotransmitter release; overexpression; plasmalemma; protein function; research study; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; structure function relationship; synapse function; synaptic function; synaptobrevin; syntaxin; trafficking; vesicle-associated membrane protein",The role of tomosyn in synaptic transmission,,73156,ZRG1,Special Emphasis Panel,,5,312165,
7755391,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073673-05,,NIMH:292474;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HOFFMAN, RALPH EDWARD;",1864960;,5R01MH073673,02/01/2006,01/31/2011,"Active Follow-up; Algorithms; Area; Area, Wernicke; Auditory Cortex; Auditory Hallucination; Auditory area; Behavioral; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Cerebrum; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Data; Diagnosis; Distant; Distress; Drugs; Dysfunction; Encephalon; Encephalons; Enrollment; Equipment and supply inventories; Follow-Up Studies; Followup Studies; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Functional disorder; Functional impairment; Generations; Hallucination, Auditory; Hallucinations; Handedness; Individual; Inpatients; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Inventory; Investigators; Language; Laterality; Left; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Maps; Masks; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; NIMH; NMR Imaging; NMR Tomography; National Institute of Mental Health; National Institute of Mental Health (U.S.); Nervous System, Brain; Neuropsychologic Tests; Neuropsychological Tests; Nuclear Magnetic Resonance Imaging; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Pilot Projects; Play; Position; Positioning Attribute; Prefrontal Cortex; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; QOL; Quality of life; Questionnaires; Randomized; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; Resistance; Role; SCHED; Safety; Schedule; Schizoaffective Disorders; Schizophrenia; Schizophrenic Disorders; Series; Severities; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Speech; Speech Perception; Superior temporal gyrus; Surface; Symptoms; Syndrome; Temporal Lobe; Testing; Translational Research; Translational Research Enterprise; Translational Science; United States National Institute of Mental Health; Voice; Wernicke Area; Zeugmatography; base; behavior measurement; behavioral measure; behavioral measurement; biological signal transduction; clinical efficacy; clinical investigation; dementia praecox; design; designing; dosage; drug/agent; enroll; experience; fMRI; falls; follow-up; functional disability; insight; interventional strategy; neuropsychiatric; neuropsychiatry; open label; pathophysiology; pilot study; primary outcome; programs; public health medicine (field); randomisation; randomization; randomly assigned; repetitive transcranial magnetic stimulation; resistant; response; schizophrenic; secondary outcome; simulation; social role; speech processing; temporal cortex; temporal lobe/cortex; translation research enterprise",rTMS Clinical Trial for Auditory Hallucinations,,73673,ZMH1,Special Emphasis Panel,,5,292474,
7755444,R01,MH,5,,01/01/2010,12/31/2010,,5R01MH073676-05,,NIMH:316729;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CONN, P JEFFREY;",1886557;,5R01MH073676,01/01/2006,12/31/2010,"(3-O-hexyloxy)-TZTP; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3-(3-O-hexyl-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine; 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride; AC-42; AC42; Acetylcholine; Acetylcholine Agents; Adverse effects; Agonist; Allosteric Site; Ammon Horn; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Assay; Behavioral; Binding Sites; Bioassay; Biologic Assays; Biological Assay; Cells; Chemicals; Cholinergic Agents; Cholinergic Agonists, Muscarinic; Cholinergic Drugs; Cholinergics; Clinical; Clinical Research; Clinical Study; Cognitive; Combining Site; Cornu Ammonis; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Drugs; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; FOS gene; Fore-Brain; Forebrain; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G0S7; High Throughput Assay; Hippocampus; Hippocampus (Brain); Industry; Investigators; Knockout Mice; Laboratories; Libraries; M1 receptor; Major Tranquilizers; Mammals, Mice; Measures; Mediating; Medication; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinic Agonists; Muscarinic M1 Receptor; Nerve Transmitter Substances; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurotransmitters; Nucleus Accumbens; Null Mouse; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Protooncogene FOS; Psychoses; Psychotic Disorders; Reactive Site; Receptor Activation; Receptor Protein; Receptor Signaling; Receptor, Muscarinic M1; Receptors, Muscarinic; Relative; Relative (related person); Research Personnel; Researchers; Role; Schizophrenia; Schizophrenic Disorders; Site; Specificity; Structure; Symptoms; Technology; Testing; Tranquilizing Agents, Major; Transmission; Treatment Side Effects; Wild Type Mouse; atypical antipsychotic; c fos; c-fos Gene; c-fos Proto-Oncogenes; cholinergic; clinical effect; cognitive function; dementia praecox; drug/agent; high throughput screening; hippocampal; immunoreactivity; improved; neurodegenerative illness; new approaches; novel; novel approaches; novel strategies; novel strategy; patch clamp; programs; receptor; response; schizophrenic; side effect; small molecule; small molecule libraries; social role; therapy adverse effect; tool; transmission process; treatment adverse effect; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; xanomeline",Muscarinic receptor activators as novel antipsychotic agents,,73676,ZRG1,Special Emphasis Panel,,5,316729,
7767747,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073689-05,,NIMH:333284;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,NEUROSCIENCES,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"SHAPIRO, MATTHEW L;",6472253;,5R01MH073689,02/01/2006,01/31/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Amnesia; Amnesia-Memory Loss; Animals; Apoplexy; Arm; Behavior; Behavioral; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Code; Coding System; Cods; Cognitive; Cognitive Discrimination; Common Rat Strains; Consensus; Cornu Ammonis; Cues; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Development; Discrimination; Discrimination (Psychology); Encephalon; Encephalons; Environment; Episodic memory; Episodic memory, function; Event; Food; Functional RNA; Future; Gadidae; Goals; Habits; Hippocampal Formation; Hippocampus; Hippocampus (Brain); Human; Human, General; Hunger; Intracellular Communication and Signaling; Investigators; Learning; Lesion; Location; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropsychologies; Neuropsychology; Non-Coding; Non-Coding RNA; Outcome; Pattern; Performance; Physiology; Population; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Pus; Rat; Rattus; Research; Research Personnel; Researchers; Residual; Residual state; Rodent; Rodentia; Rodentias; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stimulus; Stroke; Structure; Task Performances; Testing; Thirst; Training; Upper arm; Vascular Accident, Brain; base; biological signal transduction; brain attack; cerebral vascular accident; dementia of the Alzheimer type; deprivation; design; designing; episodic like memory; experiment; experimental research; experimental study; flexibility; hippocampal; memory retrieval; neural; neural prosthesis; neural prosthetic; neuronal; neuropsychologic; new approaches; novel; novel approaches; novel strategies; novel strategy; primary degenerative dementia; programs; prospective; prospective memory; relating to nervous system; research study; senile dementia of the Alzheimer type; skills; stroke; working memory",Prospective memory coding by the hippocampus,,73689,LAM,Neurobiology of Learning and Memory Study Section,,5,333284,
7761235,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073765-05,,NIMH:340821;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"RAPAPORT, MARK HYMAN;",1912737;,5R01MH073765,02/01/2006,01/31/2011,"21+ years old; A(1)-Acid Seromucoid; Acid Seromucoid; Acids; Acute-Phase Proteins; Address; Adhesives; Adult; Affective Disorders; Alternative Medicine; American Heart Association; Analysis, Data; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Apolipoproteins; Arachidonic Acids; Area; Arm; Award; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biochemical; Biological; Blood Plasma; Blood Sample; Blood erythrocyte; Blood normocyte; Blood specimen; Budgets; C-reactive protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cardiac Diseases; Cardiac Disorders; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell membrane; Characteristics; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Consumption; Coordination and Collaboration; Country; Cytoplasmic Membrane; Data; Data Analyses; Data Banks; Data Bases; Data Reporting; Databank, Electronic; Databanks; Database, Electronic; Databases; Depressed mood; Depression; Depressive disorder; Development; Diet; Dietary Supplementation; Dietary intake; Differentiation Factor, B-Cell; Disease; Disease remission; Disorder; Doctor of Philosophy; Documentation; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Dysfunction; ELIG; Eligibility; Eligibility Determination; Epidemiology; Erythrocytes; Erythrocytic; Fatty Acids; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Polyunsaturated; Fishes; Food; Functional disorder; General Hospitals; Goals; Guidelines; HAM-D; HPGF; Hamilton Depression Scale; Hamilton Rating Scale for Depression; Head; Heart Diseases; Hepatocyte-Stimulating Factor; History; Hospitals, General; Human Resources; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-1 beta; IL-1-b; IL-6; IL1-Beta; IL1B Protein; IL1F2; IL6 Protein; Immune; Immune Markers; Immune system; Immunologic Factors; Immunologic Markers; Immunological Factors; Incidence; Individual; Inflammatory; Intake; Interleukin 1, Beta Proprotein; Interleukin 1beta; Interleukin 6 (Interferon, Beta 2); Interleukin-1 beta; Interleukin-6; Investigators; Lead; Leadership; Life Style; Lifestyle; Lipids; Lipoproteins; Literature; MGI-2; Major Depressive Disorder; Manpower; Markers, Surrogate; Marrow erythrocyte; Massachusetts; Measurement; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Medical center; Mental Depression; Mentors; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Monitor; Mood Disorders; Moods; Myeloid Differentiation-Inducing Protein; N-6 Fatty Acids; NCCAM; NIMH; National Center for Complementary and Alternative Medicine; National Institute of Mental Health; National Institute of Mental Health (U.S.); Natural Remedy; Negotiating; Negotiation; Neurosis, Depressive; Normal Range; Normal Values; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Omega-6 Fatty Acids; Omega-6 PUFAs; Organ System, Cardiovascular; Orosomucoid; Outcome; PBO; Pathogenesis; Pathway interactions; Patients; Pb element; Persons; Ph.D.; PhD; Phone; Physiologic; Physiological; Physiopathology; Placebo Control; Placebos; Plasma; Plasma Membrane; Plasmacytoma Growth Factor; Play; Policies; Polyunsaturated Fatty Acids; Population Study; Predisposition; Preinterleukin 1 Beta; Preparation; Prevalence; Prevention therapy; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protein C; Proteins, specific or class, C-reactive; Protocol; Protocol Screening; Protocols documentation; Psychiatry; Publications; Publishing; Qualifying; Quality Control; R01 Mechanism; R01 Program; RMSN; RPG; Randomized; Reactants, Acute-Phase; Recording of previous events; Recruitment Activity; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relative; Relative (related person); Remedy, Natural; Remission; Reporting; Reporting, Data; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rest; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Serum, Plasma; Role; SCHED; Schedule; Science; Scientific Publication; Seromucoid; Serum Sialomucin; Serum, Plasma; Sham Treatment; Shipping; Ships; Site; Site Visit; Societies; Stress; Supplementation; Surrogate Markers; Susceptibility; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Telephone; Testing; Textbooks; Time; Traction; Training; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); United States National Institute of Mental Health; Upper arm; Vascular, Heart; Visit; Work; Writing; adult human (21+); alpha 1-Acid Glycoprotein; alpha 1-Acid Seromucoid; base; blood corpuscles; body system, allergic/immunologic; cardiovascular disorder; cell type; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical practice; clinical significance; clinically significant; computerized data processing; conference; control trial; cytokine; data processing; data repository; depressed; design; designing; disease/disorder; efficacy trial; eicosapentanoic acid; experience; fat metabolism; heart disorder; heavy metal Pb; heavy metal lead; human TNF protein; immunologic substance; immunological substance; interferon beta 2; lipid metabolism; major depression; meetings; member; n-3 Fatty Acids; omega-3; organ system, allergic/immunologic; pathophysiology; pathway; personnel; plasmalemma; polyunsaturated fatty acid; programs; psychoimmunology; quality assurance; randomisation; randomization; randomly assigned; recruit; relational database; response; sadness; sham therapy; signal processing; social role; symposium; treatment response; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",Omega-3 Fatty Acids for Treatment of Major Depressive Disorder,,73765,ZMH1,Special Emphasis Panel,,5,340821,
7761721,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH073856-05,,NIMH:389965;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAINT LOUIS,UNITED STATES,PSYCHIATRY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"BLACK, KEVIN J;",1886609;,5R01MH073856,02/15/2006,01/31/2011,"(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid; (--)-3-(3,4-Dihydroxyphenyl)-L-alanine; 0-11 years old; 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)-; 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole; 2-amino-6-propylaminotetrahydrobenzothiazole; 21+ years old; 3,4-Dihydroxyphenethylamine; 3-Hydroxy-L-tyrosine; 4-(2-Aminoethyl)-1,2-benzenediol; AD/HD; ADHD; Adult; Affect; Agonist; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate, (S)-; Blood Plasma; Brain; Brain region; Carbidopa; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Children (0-21); Chronic; Clinical; Cognitive; Comorbidity; Data; Development; Dopamine; Dopamine Agonists; Dopamine Receptor; Dopamine Receptor Agonists; Dopaminergic Agonists; Dose; Drugs; Dysfunction; Education; Educational aspects; Employment; Encephalon; Encephalons; Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Future; Genetic; Gilles de la Tourette syndrome; Gilles de la Tourette's Disease; Guinon's disease; History; Human, Adult; Human, Child; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Image; Individual; Infusion; Infusion procedures; Intracellular Communication and Signaling; Investigators; L-3,4-Dihydroxyphenylalanine; L-Dopa; Levodopa; MRI, Functional; Magnetic Resonance Imaging, Functional; Major Tranquilizers; Medial; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methyldopahydrazine; Nervous System, Brain; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; PBO; Parietal Lobe; Parietal Lobe of the Brain; Performance; Pergolide; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Physiologic Imaging; Physiopathology; Placebo Effect; Placebos; Plasma; Programs (PT); Programs [Publication Type]; Receptor Activation; Recording of previous events; Research; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Saline; Saline Solution; Sampling; Scanning; Schools; Serum, Plasma; Severities; Sham Treatment; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Symptoms; Testing; Thalamic structure; Thalamus; Tic Disorder, Combined Vocal and Multiple Motor; Tic disorder; Time; Tourette Syndrome; Tourette's; Tourette's Disease; Tourette's Disorder; Tourette's Syndrome; Tranquilizing Agents, Major; adult human (21+); attention deficit hyperactive disorder; beta-(3,4-Dihydroxyphenyl)-L-alanine; biological signal transduction; children; disability; drug/agent; endophenotype; expectancy effect; expectation effect; fMRI; frontal cortex; frontal lobe; imaging; improved; maladie des tics; neuroimaging; nocebo; parietal cortex; pathophysiology; placebo response; pramipexol; pramipexole; programs; response; sham therapy; social; thalamic; tic de Guinon; working memory; youngster",Dopaminergic Effects on Cortical Function in Tourette's,,73856,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,5,389965,
7776936,R01,MH,5,,03/01/2010,02/28/2011,PA-01-123,5R01MH074085-05,,NIMH:344099;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"MISCHOULON, DAVID ;",3040290;,5R01MH074085,03/09/2006,02/28/2011,"21+ years old; A(1)-Acid Seromucoid; Acid Seromucoid; Acids; Acute-Phase Proteins; Address; Adhesives; Adult; Affective Disorders; Alternative Medicine; American Heart Association; Analysis, Data; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Apolipoproteins; Arachidonic Acids; Area; Arm; Award; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biochemical; Biological; Blood Plasma; Blood Sample; Blood Serum; Blood erythrocyte; Blood normocyte; Blood specimen; Budgets; C-reactive protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cardiac Diseases; Cardiac Disorders; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell membrane; Characteristics; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Consumption; Coordination and Collaboration; Country; Cytoplasmic Membrane; Data; Data Analyses; Data Banks; Data Bases; Data Reporting; Databank, Electronic; Databanks; Database, Electronic; Databases; Depressed mood; Depression; Depressive disorder; Development; Diet; Dietary Supplementation; Dietary intake; Differentiation Factor, B-Cell; Disease; Disease remission; Disorder; Doctor of Philosophy; Documentation; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Dysfunction; ELIG; Eligibility; Eligibility Determination; Epidemiology; Erythrocytes; Erythrocytic; Fatty Acids; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Polyunsaturated; Fishes; Food; Functional disorder; General Hospitals; Goals; Guidelines; HAM-D; HPGF; Hamilton Depression Scale; Hamilton Rating Scale for Depression; Head; Heart Diseases; Hepatocyte-Stimulating Factor; History; Hospitals, General; Human Resources; Human, Adult; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-1 beta; IL-1-b; IL-6; IL1-Beta; IL1B Protein; IL1F2; IL6 Protein; Immune; Immune Markers; Immune system; Immunologic Factors; Immunologic Markers; Immunological Factors; Incidence; Individual; Inflammatory; Intake; Interleukin 1, Beta Proprotein; Interleukin 1beta; Interleukin 6 (Interferon, Beta 2); Interleukin-1 beta; Interleukin-6; Investigators; Lead; Leadership; Life Style; Lifestyle; Lipids; Lipoproteins; Literature; MGI-2; Major Depressive Disorder; Manpower; Markers, Surrogate; Marrow erythrocyte; Massachusetts; Measurement; Measures; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Medical center; Mental Depression; Mentors; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Monitor; Mood Disorders; Moods; Myeloid Differentiation-Inducing Protein; N-6 Fatty Acids; NCCAM; NIMH; National Center for Complementary and Alternative Medicine; National Institute of Mental Health; National Institute of Mental Health (U.S.); Natural Remedy; Negotiating; Negotiation; Neurosis, Depressive; Normal Range; Normal Values; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Omega-6 Fatty Acids; Omega-6 PUFAs; Organ System, Cardiovascular; Orosomucoid; Outcome; PBO; Pathogenesis; Pathway interactions; Patients; Pb element; Persons; Ph.D.; PhD; Phone; Physiologic; Physiological; Physiopathology; Placebo Control; Placebos; Plasma; Plasma Membrane; Plasmacytoma Growth Factor; Play; Policies; Polyunsaturated Fatty Acids; Population Study; Predisposition; Preinterleukin 1 Beta; Preparation; Prevalence; Prevention therapy; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protein C; Proteins, specific or class, C-reactive; Protocol; Protocol Screening; Protocols documentation; Psychiatry; Publications; Publishing; Qualifying; Quality Control; R01 Mechanism; R01 Program; RMSN; RPG; Randomized; Reactants, Acute-Phase; Recording of previous events; Recruitment Activity; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relative; Relative (related person); Remedy, Natural; Remission; Reporting; Reporting, Data; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rest; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Serum, Plasma; Role; SCHED; Schedule; Science; Scientific Publication; Seromucoid; Serum; Serum Sialomucin; Serum, Plasma; Sham Treatment; Shipping; Ships; Site; Site Visit; Societies; Stress; Supplementation; Surrogate Markers; Susceptibility; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Telephone; Testing; Textbooks; Time; Traction; Training; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); United States National Institute of Mental Health; Upper arm; Vascular, Heart; Visit; Work; Writing; adult human (21+); alpha 1-Acid Glycoprotein; alpha 1-Acid Seromucoid; base; blood corpuscles; body system, allergic/immunologic; cardiovascular disorder; cell type; circulatory system; clinical data repository; clinical data warehouse; clinical investigation; clinical practice; clinical significance; clinically significant; computerized data processing; conference; control trial; cytokine; data processing; data repository; depressed; design; designing; disease/disorder; efficacy trial; eicosapentanoic acid; experience; fat metabolism; heart disorder; heavy metal Pb; heavy metal lead; human TNF protein; immunologic substance; immunological substance; interferon beta 2; lipid metabolism; major depression; meetings; member; n-3 Fatty Acids; omega-3; organ system, allergic/immunologic; pathophysiology; pathway; personnel; plasmalemma; polyunsaturated fatty acid; programs; psychoimmunology; quality assurance; randomisation; randomization; randomly assigned; recruit; relational database; response; sadness; sham therapy; signal processing; social role; symposium; treatment response; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human",Omega-3 Fatty Acids for Treatment of Major Depression,,74085,ZMH1,Special Emphasis Panel,,5,344099,
7751789,R01,MH,5,,01/01/2010,12/31/2010,,5R01MH074374-05,,NIMH:629866;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEWARK,UNITED STATES,PSYCHOLOGY,00,059007500,US,DE,19716,UNIVERSITY OF DELAWARE,"DOZIER, MARY ;",1897374;,5R01MH074374,02/01/2006,12/31/2010,"0-11 years old; Behavioral; Birth; Care Givers; Caregivers; Caring; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Children (0-21); Community Services; Control Groups; Development; Domestic Violence; Early treatment; Education; Educational aspects; Educational process of instructing; Effectiveness of Interventions; Emotional; Environment; Family; Housing; Human, Child; Infant; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Lead; Learning; Life; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Mothers; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Outcome; Parenting; Parenting behavior; Parents; Participant; Parturition; Pb element; Pennsylvania; Position; Positioning Attribute; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Randomized; Regulation; Research Personnel; Researchers; Services; Signal Transduction; Signal Transduction Systems; Signaling; Substance abuse problem; System; System, LOINC Axis 4; Teaching; Testing; Time; Toddler; Trust; Unspecified Mental Disorder; abuse of substances; alternative treatment; anti social; antisocial; biobehavior; biobehavioral; biological signal transduction; care giving; caregiving; child protection services; child protective service; children; coping; design; designing; early experience; effect of intervention; experience; heavy metal Pb; heavy metal lead; high risk; interventional strategy; maltreated children; maltreatment; mental illness; mistreatment; neglect; perpetrators; post intervention; psychological disorder; randomisation; randomization; randomly assigned; skills; substance abuse; youngster",Specialized services for high-risk birth parents,,74374,SRV,Services Research Review Committee,,5,629866,
7755360,R01,MH,5,,01/01/2010,12/31/2010,,5R01MH074692-04,,NIMH:302406;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHOLOGY,08,041968306,US,NY,100122331,NEW YORK UNIVERSITY,"DAVACHI, LILA ;",6435810;,5R01MH074692,01/01/2007,12/31/2011,"Address; Aging; Agreement; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Architecture; Binding; Binding (Molecular Function); Brain; Cell Communication and Signaling; Cell Signaling; Complex; Consensus; Cornu Ammonis; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Depression; Disease; Disease Progression; Disorder; Dysfunction; Encephalon; Encephalons; Engineering / Architecture; Episodic memory; Episodic memory, function; Event; Exhibits; Familiarity; Functional Magnetic Resonance Imaging; Functional disorder; Glean; Hippocampus; Hippocampus (Brain); Human; Human, General; Influentials; Intracellular Communication and Signaling; Investigation; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Medial; Memory; Mental Depression; Methods and Techniques; Methods, Other; Modeling; Molecular Interaction; Nature; Nervous System, Brain; Operation; Operative Procedures; Operative Surgical Procedures; Performance; Physiologic; Physiological; Physiopathology; Position; Positioning Attribute; Primary Senile Degenerative Dementia; Process; Psychopathology; Public Health; Research; Resolution; Retrieval; Role; Schizophrenia; Schizophrenic Disorders; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stimulus; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Temporal Lobe; Testing; Time; abnormal psychology; association cortex; base; biological signal transduction; dementia of the Alzheimer type; dementia praecox; design; designing; disease/disorder; experiment; experimental research; experimental study; fMRI; hippocampal; insight; memory retrieval; neural mechanism; neuromechanism; neuropsychiatric; neuropsychiatry; pathophysiology; primary degenerative dementia; public health medicine (field); research study; role model; schizophrenic; senescent; senile dementia of the Alzheimer type; social role; surgery; temporal cortex; temporal lobe/cortex",Medial temporal lobe contributions to episodic memory,,74692,LAM,Neurobiology of Learning and Memory Study Section,,4,302406,
7770826,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH074794-04,,NIMH:354375;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"WESTIN, CARL-FREDRIK ;",6972801;,5R01MH074794,02/15/2007,01/31/2012,"Affective Disorders; Algorithms; Anisotropy; Applications Grants; Area; Articulation; Atlases; Automation; Award; Behavioral; Body of uterus; Brain; Brain Diseases; Brain Disorders; Brain imaging; Brain region; Causality; Characteristics; Chronic; Clinical; Cluster Analyses; Cluster Analysis; Cognitive; Collaborations; Communities; Companions; Complex; Corpus; Corpus Callosum; Corpus Callosums; Corpus Uteri; Data; Data Set; Dataset; Diagnosis; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Dysfunction; Early Diagnosis; Encephalon; Encephalon Diseases; Encephalons; Etiology; Fiber; Figs; Figs - dietary; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Grant; Grant Proposals; Grants, Applications; Graph; Grouping; Human; Human, General; Image; Image Analyses; Image Analysis; Imagery; Imaging Procedures; Imaging Techniques; Infant; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigators; Joints; Knowledge; Left; Letters; Limbic System; Literature; MR Imaging; MR Tomography; MRI; MRI, Functional; MS Lesions; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Manuals; Maps; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medicine; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Mood Disorders; Multiple Sclerosis Lesions; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); National Library of Medicine; National Library of Medicine (U.S.); National Medical Library; Neighborhoods; Nervous; Nervous System, Brain; Neurosciences; Neurosurgical Procedures; Nuclear Magnetic Resonance Imaging; Patients; Physiopathology; Population; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Psychoses; Psychotic Disorders; ROC Analysis; Reporting; Research; Research Personnel; Researchers; Scanning; Schizophrenia; Schizophrenic Disorders; Science of Medicine; Specific qualifier value; Specified; Structure; Surgery, Neurological; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Technology; Testing; Uncertainty; United States National Institutes of Health; United States National Library of Medicine; Uterine Body; Visualization; Weight; Work; Zeugmatography; base; brain visualization; computerized; dementia praecox; diffusion tensor imaging; disease causation; disease etiology; disease/disorder etiology; disorder etiology; doubt; early detection; experience; fMRI; first episode schizophrenia; frontal cortex; frontal lobe; gray matter; groupings; image evaluation; image processing; imaging; imaging modality; improved; in vivo; insight; interest; neural; new approaches; new technology; novel; novel approaches; novel strategies; novel strategy; open source; pathophysiology; patient population; programs; relating to nervous system; schizophrenic; substantia alba; substantia grisea; tool; water diffusion; white matter; white matter damage",Novel DT-MRI Analyses of White Matter in Schizophrenia,,74794,ZRG1,Special Emphasis Panel,,4,354375,
7779987,R01,MH,5,,03/01/2010,02/28/2011,,5R01MH075025-04,,NIMH:272770;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,INDIANAPOLIS,UNITED STATES,PSYCHIATRY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"ANAND, AMIT ;",2289277;,5R01MH075025,03/17/2007,02/28/2011,"5HT transporter; 5HTT protein; Acute; Affect; Affective Psychosis, Bipolar; After Care; After-Treatment; Aftercare; Age; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Area; Arm; Arts; BDNF; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Characteristics; Chronic; Control Groups; Data; Depressed mood; Depression, Unipolar; Disease; Disorder; Dysfunction; Emotions; Encephalon; Encephalons; Ethnic Origin; Ethnicity; Ethnicity aspects; Exhibits; Face; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Gender; Genetic; Genetic Polymorphism; Genetics, Other; Genotype; Imaging Procedures; Imaging Techniques; Investigation; Knowledge; Lead; Li+ element; Link; Literature; Lithium; MGC34632; MRI, Functional; Magnetic Resonance Imaging, Functional; Manias; Manic; Manic State; Measures; Medial; Methods and Techniques; Methods, Other; Mood stabilizers; Moods; Nervous System, Brain; Other Genetics; Patients; Pattern; Pb element; Phase; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Principal Investigator; Programs (PT); Programs [Publication Type]; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Psychosis, Manic-Depressive; Publishing; Rest; SUBGP; Scanning; Severity of illness; Side; Stimulus; Striatum, Ventral; Subgroup; Technics, Imaging; Techniques; Thalamic structure; Thalamus; Time; Unipolar Depression; Upper arm; Variant; Variation; Ventral Striatum; amygdaloid nuclear complex; bipolar affective disorder; blood oxygen level dependent; cingulate cortex; depressed; disease severity; disease subtype; disease/disorder; disorder subtype; fMRI; facial; genetic promoter element; heavy metal Pb; heavy metal lead; interest; manic depressive disorder; manic depressive illness; mood regulation; novel; pathophysiology; polymorphism; programs; response; sadness; serotonin transporter; sodium-dependent serotonin transporter; thalamic; time use; treatment effect",Dysfunctional Cortico-Limbic Activity and Connectivity in Bipolar Disorder and Li,,75025,ZRG1,Special Emphasis Panel,,4,272770,
7758717,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH076051-03,,NIMH:568619;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,15,167204994,US,NY,10032,NEW YORK STATE PSYCHIATRIC INSTITUTE,"BLANCO, CARLOS ;",6069137;,5R01MH076051,02/01/2008,01/31/2013,"Algorithms; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Arm; Clinical; Data; Depressed mood; Depression; Disadvantaged; Dropout; Drug Therapy; Drugs; Evidence based treatment; Face; Foundations; Hispanic Populations; Hispanics; Hispanics or Latinos; Insurance; Intervention; Intervention Strategies; Latino Population; Literature; Major Depressive Disorder; Medicaid; Medication; Mental Depression; Mental Health Services; Mental Hygiene Services; Methods; Non-Hispanic; Not Hispanic or Latino; Outcome; PYMT; Patient Preferences; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phone; Population; Preferences, Patient; Principal Investigator; Programs (PT); Programs [Publication Type]; Psychotherapy; Public Health; Randomized; Regimen; Services; Spanish Origin; Telephone; Texas; Treatment Effectiveness; Treatment Efficacy; Upper arm; Visit; base; care delivery; delivery of care; depressed; drug/agent; facial; hispanic community; improved; intervention development; interventional strategy; major depression; patient centered; patient oriented; payment; programs; psychologic; psychological; public health medicine (field); randomisation; randomization; randomized trial; randomly assigned; sadness; satisfaction; socioeconomic; socioeconomically; socioeconomics; successful intervention; therapeutic efficacy; therapeutically effective; therapy development; treatment development",Improving the Effectiveness of Treatment for Depression in Hispanics,,76051,SRNS,Mental Health Services in Non-Specialty Settings,,3,568619,
7766920,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH076090-05,,NIMH:315697;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ATLANTA,UNITED STATES,GENETICS,05,066469933,US,GA,30322,EMORY UNIVERSITY,"JIN, PENG ;",7081055;,5R01MH076090,02/01/2006,01/31/2011,"Affect; Behavior; Behavioral; Biochemical Genetics; Biological Models; Brain; CNS plasticity; Cells; Circadian Rhythms; Cloning; Collection; Complex; Courtship; DICER1; DICER1 Protein; DICER1 protein, human; Dcr-1 Homolog; Defect; Dendritic Spines; Dicer; Dicer1, Dcr-1 homolog (Drosophila) protein, human; Diurnal Rhythm; Drosophila; Drosophila FMR1 protein; Drosophila genus; EC 3.1.26.-; Encephalon; Encephalons; Endoribonuclease Dicer; Escalante syndrome; Eye; Eyeball; FMR-1 Protein; FMR1 Protein; FMR1 protein, Drosophila; FMR1 protein, fragile X; FMRP protein; FXR protein, Drosophila; Family; Flies; Fragile X; Fragile X Mental Retardation Protein; Fragile X Syndrome; Fruit Fly, Drosophila; Genes; Genetic; Genetic Screening; Genetic, Biochemical; Goals; HERNA; HERNA protein, human; Helicase with RNase Motif; Helicase-MOI; Hereditary; Homolog of Drosophila Dicer; Human; Human, General; In Vitro; Inherited; Investigators; K12H4.8-Like; KIAA0928; Laboratories; Ligands; Man (Taxonomy); Man, Modern; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Mediating; Mental Retardation; Messenger RNA; Micro RNA; Micro-tubule; MicroRNAs; Microtubules; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Development; Neurites; Neurocyte; Neuronal Plasticity; Neurons; Nyctohemeral Rhythm; P element; Pathogenesis; Pathway interactions; Patients; Peptide Biosynthesis, Ribosomal; Peptide Domain; Phenotype; Phosphorus; Polyribosomes; Polysomes; Process; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Domains; Protein Synthesis, Ribosomal; Proteins; Protocol; Protocols documentation; RNA, Messenger; RNA, Noncoding; RNA, Nontranslated; RNA, Untranslated; RNA-Binding Proteins; Regulation; Renpenning syndrome 2; Reporting; Research Personnel; Researchers; Role; Series; Small RNA; Synapses; Synaptic; Tertiary Protein Structure; Testing; Translational Regulation; Translations; Twenty-Four Hour Rhythm; Untranslated RNA; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; base; circadian; circadian process; compound eye; dFMR1 protein, Drosophila; dFXR protein, Drosophila; dFmr1 protein; dFmrp; daily biorhythm; dendrite spine; diurnal variation; fly; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X mental retardation-1 protein; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; fruit fly; gene product; human DICER1 protein; in vivo; mRNA; mRNP; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; mar(X) syndrome; marker X syndrome; member; mental retardation-macroorchidism syndrome; messenger ribonucleoprotein; miRNA; mouse model; mutant; neural plasticity; neurodevelopment; neuronal; neuroplasticity; novel; pathway; programs; protein synthesis; social role",Dissecting the molecular basis of fragile X syndrome in Drosophila,,76090,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,5,315697,
7760112,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH077047-04,,NIMH:581406;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,STANFORD,UNITED STATES,PSYCHIATRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"CHANG, KIKI D;",2220248;,5R01MH077047,02/08/2007,01/31/2012,"0-11 years old; 12-20 years old; 21+ years old; 5HT transporter; 5HTT protein; AD/HD; ADHD; AOD use; Active Follow-up; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Affective; Affective Disorders; Affective Psychosis, Bipolar; Age; Alcohol or Other Drugs use; Alleles; Allelomorphs; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anxiety Disorders; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; BDGF; Behavior; Behavior Disorder, Disruptive; Behavioral; Biologic Marker; Biological; Biological Markers; Bipolar Disorder; Blood; Blood Coagulation Factor V, Activated; Blood-coagulation factor Va; Brain; Candidate Disease Gene; Candidate Gene; Causality; Characteristics; Child; Child Support; Child Youth; Childhood; Children (0-21); Chronic; Coagulation Factor Va; Code; Coding System; Collaborations; Comorbidity; Control Groups; Cornu Ammonis; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Depression; Development; Disease; Disease Frequency Surveys; Disorder; Disruptive Behavior Disorder; Drugs; Dysfunction; Early identification; Encephalon; Encephalons; Environment; Environmental Factor; Environmental Risk Factor; Epidemiology, Family Medical History; Etiology; Evaluation; Event; Factor V, Activated; Factor Va; Family; Family Medical History; Family Study; Family history of; First Degree Relative; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; GFAC; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetic analyses; Genotype; Growth Agents; Growth Factor; Growth Factor Gene; Growth Factors, Proteins; Growth Substances; Health Care Costs; Health Costs; Healthcare Costs; Hereditary; Heritability; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, Child; Human, General; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Individual; Inherited; Inherited Predisposition; Inherited Susceptibility; Intervention; Intervention Strategies; Interview; Investigators; Laboratories; Lead; Life; Life Stress; Link; Longitudinal Studies; MRI, Functional; Magnetic Resonance Imaging, Functional; Major Depressive Disorder; Man (Taxonomy); Man, Modern; Manias; Manic; Manic State; Medication; Mental Depression; Molecular Marker; Mood Disorders; Moods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, Brain; Neurobiology; Neuromediator Receptors; Neuroregulator Receptors; Neurotransmitter Receptor; Normal Range; Normal Values; Outcome; Parents; Pathogenesis; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Study; Position; Positioning Attribute; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Proto-Oncogene, Growth Factor; Psychiatry; Psychosis, Manic-Depressive; Psychosocial Factor; Questionnaires; Receptors, Neurohumor; Recurrence; Recurrent; Relative; Relative (related person); Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Retrospective Studies; Risk; Risk Factors; Risk Marker; Sampling; Scanning; Severities; Severity of illness; Siblings; Signature Molecule; Stress; Structure; Substance abuse problem; Suicide; Suicide attempt; Support, Child; Symptoms; Testing; Twin Multiple Birth; Twins; United States National Institutes of Health; Variation (Genetics); Work; abuse of substances; accomplished suicide; adolescence (12-20); adult human (21+); allelic variant; amygdaloid nuclear complex; attention deficit hyperactive disorder; base; biomarker; bipolar affective disorder; brain growth promoting activity; brain trophin; brain-derived growth factor; childhood bipolar disorder; children; cohort; commit suicide; completed suicide; design; designing; disease causation; disease etiology; disease severity; disease/disorder; disease/disorder etiology; disorder etiology; disruptive behavioral disorder; drug/agent; early onset; endophenotype; environmental risk; executive control; executive function; experience; fMRI; fatal attempt; fatal suicide; follow-up; genetic analysis; genetic etiology; genetic mechanism of disease; genetic vulnerability; gray matter; heavy metal Pb; heavy metal lead; high risk; hippocampal; intent to die; interventional strategy; juvenile; juvenile human; long-term study; major depression; manic depressive disorder; manic depressive illness; neural circuit; neural circuitry; neurobiological; neuroimaging; non fatal attempt; offspring; pathophysiology; patient population; pediatric; polymorphism; prevent; preventing; proband; programs; psychosocial; psychosocial variables; receptor density; repository; response; serotonin transporter; sodium-dependent serotonin transporter; stressor; substance abuse; substance use; substantia grisea; suicidal attempt; suicidal risk; suicidality; suicide risk; teenage; tool; trait; youngster",Genetic and Neurobiologic Risk Factors for Bipolar Disorder Development,,77047,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,4,581406,
7760959,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH077073-03,,NIMH:344250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"PRESS, DANIEL Z.;",6150974;,5R01MH077073,01/08/2008,12/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine; Address; Affect; Age; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; American; Anti-Cholinesterases; Anticholinesterase Agents; Anticholinesterase Drugs; Anticholinesterases; Area; Atrophic; Atrophy; Attention Deficit Disorder; Behavioral; Brain imaging; Brain region; Budgets; Cells; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Crossover Design; Data; Delirium; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Designs, Cross-Over; Disease; Disorder; Disturbance in cognition; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Dysfunction; Economic Inflation; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Idiopathic Parkinson Disease; Image; Imaging Procedures; Imaging Techniques; Impaired cognition; Impairment; Inflation; Lateral; Lead; Lewy Body Parkinson Disease; MR Imaging; MR Tomography; MRI; MRI Scans; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Measures; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Method LOINC Axis 6; Methodology; Methods; Monitor; Motor; NMR Imaging; NMR Tomography; Nerve Transmitter Substances; Nervous; Neurochemistry; Neurotransmitters; Nuclear Magnetic Resonance Imaging; Occupational; PBO; PET; PET Scan; PET imaging; PETSCAN; PETT; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Participant; Patients; Pb element; Perfusion; Physiologic Imaging; Physiopathology; Placebo Control; Placebos; Play; Population Control; Positron Emission Tomography Scan; Positron-Emission Tomography; Primary Parkinsonism; Primary Senile Degenerative Dementia; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; QOL; Quality of life; Rad.-PET; Recruitment Activity; Role; Scans, MRI; Science of neurochemistry; Series; Sham Treatment; Suggestion; System; System, LOINC Axis 4; Technics, Imaging; Testing; Zeugmatography; base; behavior test; behavioral test; brain atrophy; brain visualization; cerebral atrophy; cerebral blood flow; cerebral circulation; cerebrocirculation; cholinergic; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cortical atrophy; delirious; dementia of the Alzheimer type; design; designing; disease/disorder; donepezil; executive control; executive function; experiment; experimental research; experimental study; fMRI; frontal cortex; frontal lobe; gray matter; heavy metal Pb; heavy metal lead; imaging; insight; mild cognitive disorder; mild cognitive impairment; mild neurocognitive disorder; neural; neurochemistry; pathophysiology; primary degenerative dementia; recruit; relating to nervous system; research study; senile dementia of the Alzheimer type; sham therapy; social role; substantia grisea",Regional and Cholinergic Basis of Executive Dysfunction in Parkinson's Disease,,77073,CND,Clinical Neuroscience and Disease Study Section,,3,344250,
7762242,R01,MH,5,,02/01/2010,01/31/2011,,5R01MH077541-04,,NIMH:522882;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,HARTFORD,UNITED STATES,,01,024371270,US,CT,061065218,INSTITUTE FOR COMMUNITY RESEARCH,"WEEKS, MARGARET R;",1964808;,5R01MH077541,02/01/2007,01/31/2012,"AIDS; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adoption; Affect; Africa; African; Application Context; Area; Asians; Award; Beauty; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior assessment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Characteristics; China; Chinese; Chinese People; Cities; Collaborations; Communities; Community Health; Conditioning Therapy; Conditions, Economic; Conditions, Economical; Condom; Condoms, Female; Condoms, Male; Condoms, Unspecified; Country; County; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Development; Development, Economic; Development, Economical; Disease; Disease Frequency Surveys; Disorder; Documentation; Economic Conditions; Economic Development; Economics; Effectiveness; Environment; Epidemic; Epidemiology; Ethnography; Evaluation; Experimental Designs; Exposure to; Factor Analyses; Factor Analysis; Female; Female Condoms; Generalized Growth; Government; Growth; HIV; HIV Prevention; HIV/AIDS prevention; HIV/STD; HTLV-III; Health; Health Promotion; Home; Home environment; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Industry; Infection; Institutes; International; Intervention; Intervention Strategies; Investigators; Knowledge; LAV-HTLV-III; Life Style Modification; Location; Lymphadenopathy-Associated Virus; Mainland China; Male Condoms; Marketing; Massage; Measures; Methods; Migrant; Natural regeneration; Nature; Nomads; Outcome; PROV; Participant; Pattern; Phase; Population; Prevention; Prevention Measures; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Prophylactic treatment; Prophylaxis; Prostitution; Province; Public Health; Regeneration; Research; Research Personnel; Research Resources; Researchers; Resources; Restaurants; Risk; Running; Rural; Salutogenesis; Sample Size; Sampling; Schools, Medical; Site; Social Change; Social Environment; Social Problems; Social Values; Social modification; Social transformation; Testing; Time; Tissue Growth; Transmission; Treatment Efficacy; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Variant; Variation; Virus-HIV; Woman; Work; base; behavior intervention; behavioral assessment; behavioral intervention; commercial sex; commercial sex work; community intervention; comparative; condoms; contextual factors; cost; design; designing; disease/disorder; enhancing factor; ethnographic; experience; fight against; high risk; innovate; innovation; innovative; intervention design; interventional strategy; male; massage therapy; medical schools; microbicidal; microbicide; model design; ontogeny; oriental; phase 2 study; population migration; prevent; preventing; programs; public health medicine (field); regenerate; sex; social; social climate; social context; social disturbance; socioenvironment; survival sex; therapeutic efficacy; therapeutically effective; therapy design; tool; transmission process; treatment design; willingness",High-risk Establishments and Women's HIV Prevention in Southern China,,77541,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,4,522882,
7756615,R01,MH,5,,02/01/2010,01/31/2011,PA-07-163,5R01MH077650-03,,NIMH:346500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LAVRETSKY, HELEN ;",2285569;,5R01MH077650,02/01/2008,01/31/2013,"2-Piperidineacetic acid, alpha-phenyl-, methyl ester; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT; 5-HT-2A Gene; 5-HT2A; 5-Hydroxytryptamine; 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene; 5-Hydroxytryptamine Receptor 2A Gene; 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-; 5HT; Active Follow-up; Acute; Address; Admission; Admission activity; Adverse effects; Advertising; Affective; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Aging; Allele Frequency; Ambulatory Care; Ambulatory Care Facilities; Amentia; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Asians; Attention Concentration; Behavior; Behavioral; Black Populations; Black or African American; Brain; Butter; Candidate Disease Gene; Candidate Gene; Care Givers; Care, Health; Caregivers; Case Study; Chronic; Chronic depressive disorder; Chronic depressive personality disorder; Citalopram; Clinic; Clinical; Clinical Management; Code; Coding System; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive Manifestations; Cognitive Symptoms; Cognitive decline; Cognitive function abnormal; Collaborations; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communities; Consent Documents; Consent Forms; Consultations; Controlled Clinical Trials; County; County Hospitals; Cytalopram; D(2C) Dopamine Receptor Gene; D(4) Dopamine Receptor Gene; D4DR Gene; DAT; DAT dopamine transporter; DRD4; DRD4 gene; Data; Dementia; Depressed mood; Depression; Development; Diabetes Mellitus; Diagnosis; Disease; Disease remission; Disorder; Disturbance in cognition; Dopamine; Dopamine Agents; Dopamine Drugs; Dopamine Receptor; Dopamine Receptor D4 Gene; Dopaminergic Agents; Dopaminergic Drugs; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Dropout; Drug Therapy; Dysfunction; Editorial Comment; Editorial Comment (PT); Elderly; Elderly depression; Elderly, over 65; Emotional Depression; Emotional well being; Encephalon; Encephalons; Enrollment; Enteramine; Ethnic Origin; Ethnicity; Ethnicity aspects; European; Family member; Feeling suicidal; Feels well; Freedom; Functional disorder; Functional impairment; Gene Frequency; Gene Organization; Gene Structure; Gene Structure/Organization; Genes; Genetic; Genetic Polymorphism; Genetic screening method; Genomics; Genotype; Geriatric Psychiatry; HAM-D; HOSP; HTR2; HTR2 Gene; HTR2A; HTR2A gene; Hamilton Depression Scale; Hamilton Rating Scale for Depression; Haplotypes; Healthcare; Heritability; Hippophaine; Hispanic Populations; Hispanics; Hispanics or Latinos; Hospitalization; Hospitals; Hospitals, County; Housing; Hydroxytyramine; IADL; Impaired cognition; Impairment; Individual; Informed Consent Documents; Informed Consent Forms; International; Intervention; Intervention Strategies; Investigators; Latino; Latino Population; Lead; Lectures; Lectures (PT); Lectures [Publication Type]; Left; Liberty; Light; Literature; Los Angeles; Major Depressive Disorder; Medical; Medical Specialities; Mental Depression; Mental Health; Mental Hygiene; Mental well-being; Method LOINC Axis 6; Methodology; Methylphenidate; Minority; Monitor; Moods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motivation; Nature; Nerve Impulse Transmission; Nerve Transmission; Nervous System, Brain; Neurobehavioral Manifestations; Neurobiology; Neuronal Transmission; Newspapers; Normal mental condition; Normal mental state; Normal psyche; Nucleotides; Olives; Olives - dietary; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Outpatient Care; Outpatient Clinics; PBO; Participant; Pathway interactions; Patient Recruitments; Patient Self-Report; Patients; Pattern; Pb element; Performance; Pharmacogenomics; Pharmacotherapy; Photoradiation; Physiopathology; Pilot Projects; Placebo Control; Placebos; Polymorphism (Genetics); Polymorphism, Genetic; Population; Principal Investigator; Probability; Programs (PT); Programs [Publication Type]; Psychiatrist; Psychiatry for older adults; Psychiatry for older people; Psychiatry for seniors; Psychiatry for the elderly; Psychogeriatrics; Psychological Health; Psychological Well Being; Published Comment; RMSN; Race; Racial Group; Randomized; Receptor Gene; Recommendation; Recovery of Function; Recruitment Activity; Recruitments, Patient; Regulation; Relapse; Relative; Relative (related person); Remission; Reporting; Research; Research Design; Research Personnel; Research Resources; Research Subjects; Researchers; Residual; Residual state; Resources; Review Literature; Risk; Role; Sampling; Self-Report; Senescence; Sense of well-being; Serotonergic Agents; Serotonergic Drugs; Serotonin; Serotonin 5-HT-2 Receptor Gene; Serotonin Agents; Serotonin Drugs; Severities; Sham Treatment; Signs and Symptoms, Neurobehavioral; Site; Source; Spanish Origin; Specialties, Medical; Specialty; Stocks, Racial; Stratification; Stress; Structure; Study Subject; Study Type; Suicidal thoughts; Suicide; Surgeon; Symptoms; Symptoms of depression; Syndrome; System; System, LOINC Axis 4; Testing; Therapeutic Studies; Therapy Research; Thinking; Thinking, function; Time; Training; Transmission; Treatment Side Effects; Utah; Viewpoint; Viewpoint (PT); Visit; Well in self; Withdrawal; Woman; Work; advanced age; alertness; allelic frequency; base; black American; case report; chronic depression; cognitive dysfunction; cognitive function; cognitive impairment no dementia; cognitive loss; cognitively impaired; conference; depressed; depressive; depressive symptoms; design; designing; diabetes; disability; disease/disorder; dopamine transporter; dopamine transporter proteins; elderly patient; elders; enroll; executive control; executive function; fatal attempt; fatal suicide; follow-up; frailty; functional disability; functional recovery; genetic testing; geriatric; geriatric depression; geriatric psychology; geropsychiatry; geropsychology; geropsychopharmacology; health disparities; health disparity; heavy metal Pb; heavy metal lead; hispanic community; improved; insight; instrumental activity of daily living; intent to die; interest; interventional strategy; late life; late life depression; later life; lectures; major depression; medical specialties; meetings; monoamine; neurobiological; neurocognitive test; neuroimaging; neuropsychiatric; neuropsychiatry; neurotransmission; older adult; older patient; older person; open label; oriental; outreach; pathophysiology; pathway; pilot study; placebo controlled study; placebo controlled trial; polymorphism; programs; psychological wellness; psychostimulant; randomisation; randomization; randomized placebo controlled study; randomized placebo controlled trial; randomly assigned; recruit; response; reuptake; sadness; self wellness; senescent; senior citizen; sham therapy; side effect; social role; study design; suicidal ideation; suicidal thinking; suicidality; suicide ideation; symposium; therapy adverse effect; thoughts about suicide; trait; transmission process; treatment adverse effect; treatment response; treatment strategy; treatment trial",Methylphenidate Use to Improve Outcomes in Geriatric Depression,,77650,APDA,Adult Psychopathology and Disorders of Aging Study Section,,3,346500,
7760549,R01,MH,5,,02/01/2010,01/31/2011,PA-07-092,5R01MH077730-03,,NIMH:529536;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,TALLAHASSEE,UNITED STATES,PSYCHOLOGY,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"WETHERBY, AMY M;",6478299;,5R01MH077730,02/07/2008,01/31/2013,"0-11 years old; Adaptive Behaviors; Address; Age; Age-Months; American Psychological Association; Analysis, Data; Appointment; Arbitrating; Arbitration; Articulation; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Award; Behaviors, Adaptive; Budgets; C 1 Esterase; C1 Esterase; C1 s; C1s; Categories; Child; Child Youth; Children (0-21); Clinical; Clinical Trials Data Monitoring Committees; Code; Codes of Ethics; Coding System; Cognitive; Collaborations; Communication; Communities; Complement 1 Esterase; Complement 1s; Complement component C1s; Computers; Confidence Intervals; Crossover Design; Data; Data Analyses; Data Banks; Data Bases; Data Monitoring Committees; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Designs, Cross-Over; Development; Diagnosis; Diagnostic; E-Mail; Early identification; Early treatment; Education; Educational aspects; Educational process of instructing; Electronic Mail; Electronics; Elements; Email; Ensure; Environment; Ethical Codes; Evaluation; FTP; Family; Florida; Funding; Generalized Growth; Grant; Growth; Health; Hour; Housing; Human, Child; Individual; Internet; Intervention; Intervention Strategies; Intervention Studies; Investigation; Investigators; Joints; Kanner's Syndrome; Language; Life; Linear Models; Link; Mails; Measurement; Measures; Michigan; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Research Council; National Research Council (U.S.); Outcome; Outcome Measure; Parents; Pattern; Phone; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publications; Randomized; Recruitment Activity; Regulation; Relative; Relative (related person); Research; Research Personnel; Research Resources; Researchers; Resources; Rights; Role; Running; SCHED; Safety Monitoring Boards; Sample Size; Sampling; Schedule; Scientific Publication; Screening procedure; Secure; Self-Help Groups; Severities; Site; Social Interaction; Staging; Support Groups; Symptoms; Teaching; Technology; Telephone; Time; TimeLine; Tissue Growth; Toddler; Training; United States National Institute of Mental Health; Universities; Update; Video Recording; Videorecording; Videotape; WWW; Work; Writing; adaptation behavior; adaptive behavior; autism spectrum disorder; base; children; clinical data repository; clinical data warehouse; compare effectiveness; conference; cost efficient; data repository; design; designing; digital; dissemination research; effective intervention; evidence base; experience; financial incentive; formycin 5'-triphosphate; formycin A 5'-triphosphate; formycin triphosphate; human subject protection; improved; interest; interventional strategy; meetings; ontogeny; programs; randomisation; randomization; randomly assigned; recruit; relational database; response; screening; screenings; self help organization; sharing data; skills; social communication; social role; symposium; video recording system; web; web site; world wide web; youngster",1/2-Effects of Parent-Implemented Intervention for Toddlers with Autism Spectrum,,77730,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,3,529536,
7761735,R01,MH,5,,02/01/2010,01/31/2011,PA-07-081,5R01MH077838-03,,NIMH:576414;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAPEL HILL,UNITED STATES,PSYCHIATRY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PEDERSEN, CORT A;",1864637;,5R01MH077838,04/28/2008,01/31/2013,"16-Hydroxyestradiol; 16-alpha-Hydroxy-Estradiol; 3,5,3',5'-Tetraiodothyronine; Accounting; Aeroseb-HC; Anxiety; Anxiety Disorders; Aquadiol; Birth; Cetacort; Chemotherapy-Hormones/Steroids; Corpus Luteum Hormone; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Data; Delta4-pregnene-3,20-dione; Depressed mood; Depression; Depression, Postpartum; Dermacort; Diagnosis; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Drops; Eldecort; Emotional Depression; Endocrine Gland Secretion; Endogenous depression; Equipment and supply inventories; Estra-1,3,5(10)-triene-3,16,17-triol, (16alpha,17beta)-; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estriol; Event; FTI; Farnesyl Transferase Inhibitor; Farnesyltransferase Inhibitors; General Population; General Public; Gestation; Goals; Gonadal Steroid Hormones; HAM-D; Hamilton Depression Scale; Hamilton Rating Scale for Depression; Head and Neck, Thyroid; History; Hormones; Hydrocortisone; Hydrocortone; Hypothalamic structure; Hypothalamus; Hytone; Interview; Interviewer; Inventory; Investigators; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; Levothyroxine; Life; Major Depressive Disorder; Measures; Mental Depression; Mothers; Normal Range; Normal Values; Nutracort; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; Ovocyclin; Ovocylin; Parturition; Perinatal; Post-Natal Depression; Post-Partum Depression; Postnatal Depression; Postpartum; Postpartum Depression; Postpartum Period; Postpartum Women; Pregn-4-ene-3,20-dione; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Pregnenedione; Proctocort; Progesterone; Progynon; Protein Farnesyltransferase Inhibitors; Puerperium; Recording of previous events; Research Personnel; Researchers; Risk Factors; Sex Hormones; Sex Steroid Hormones; Social support; Stress; Symptoms; Symptoms of depression; T4 Thyroid Hormone; Testing; Therapeutic Estradiol; Therapeutic Hormone; Therapeutic Hydrocortisone; Therapeutic Levothyroxine; Therapeutic Progesterone; Thyroid; Thyroid Function Tests; Thyroid Gland; Thyroid Gland Function Tests; Thyroid Gland Hormone; Thyroid Hormones; Thyroxine; Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-; Woman; Women, Postpartum; base; clinical depression; cohort; depressed; depressive; depressive symptoms; design; designing; disease/disorder; falls; gonadal steroids; hypothalamic; improved; indexing; major depression; meetings; minor depression; minor depressive disorder; physical abuse; physical maltreatment; pituitary thyroid axis; pregnant; prenatal; public health relevance; sadness; sex steroid; social support network; theories; thyroid function; thyroxin; unborn",Perinatal Depression & Anxiety: Relationships with Late Pregnancy Thyroid Status,,77838,APDA,Adult Psychopathology and Disorders of Aging Study Section,,3,576414,
7758703,R01,MH,5,,02/01/2010,01/31/2011,PA-07-078,5R01MH078033-03,,NIMH:648723;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PROVIDENCE,UNITED STATES,,02,069851913,US,RI,029052499,WOMEN AND INFANTS HOSPITAL-RHODE ISLAND,"SALISBURY, AMY L;",6826073;,5R01MH078033,02/01/2008,01/31/2013,"0-11 years old; 0-6 weeks old; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 21+ years old; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Address; Adult; Aeroseb-HC; Affect; Ammon Horn; Animal Neonates; Animals, Newborn; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Area; Behavioral; Birth; Blood Serum; Brain; Cetacort; Child; Child Youth; Children (0-21); Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Cornu Ammonis; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Critiques; Data; Dermacort; Development; Diagnosis, Ultrasound; Drug Exposure; Drugs; Drugs, Illicit; Echography; Echotomography; Editorial Comment; Editorial Comment (PT); Eldecort; Emotional; Encephalon; Encephalons; Enteramine; Exposure to; Fetal Age; Fetal Heart Rate; Fetal Maturity, Chronologic; Fetus; Future; Generations; Gestation; Gestational Age; Guidelines; Hand; Health, Infant; Hippocampus; Hippocampus (Brain); Hippophaine; Human; Human, Adult; Human, Child; Human, General; Hydrocortisone; Hydrocortone; Hytone; Illicit Drugs; Infant; Infant Health; Infant, Newborn; Interview; Investigators; Last Trimester; Lead; Levarterenol; Levonorepinephrine; Life; Limbic System; Major Depressive Disorder; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medical; Medical Imaging, Ultrasound; Medication; Method LOINC Axis 6; Methodology; Modeling; Monitor; Neonatal; Nerve Transmitter Substances; Nervous System, Brain; Neural Growth; Neuronal Growth; Neurotransmitters; Newborn Animals; Newborn Infant; Newborns; Noradrenaline; Norepinephrine; Nutracort; Outcome Measure; Paradoxical Sleep; Parturition; Pb element; Perinatal Exposure; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Physiologic; Physiological; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregnancy; Pregnancy Trimester, Third; Proctocort; Production; Psychiatric Diagnosis; Published Comment; REM Sleep; Rat; Rattus; Research; Research Design; Research Personnel; Researchers; Rhombencephalic Sleep; SSRI; Selective Serotonin Reuptake Inhibitor; Selective serotonin re-uptake inhibitor; Serotonin; Serum; Sleep; Sleep, Fast-Wave; Sleep, REM; Social Problems; Study Type; Substance Withdrawal Syndrome; Symptoms; System; System, LOINC Axis 4; Therapeutic Hydrocortisone; Third Pregnancy Trimester; Toxic effect; Toxicities; Transmission; Trimester, Third; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States; Viewpoint; Viewpoint (PT); Withdrawal; Withdrawal Syndrome; Woman; adult human (21+); base; children; depressed mother; diagnostic ultrasound; dreaming sleep; drug withdrawal; drug/agent; experience; fetal; fetal exposure; heavy metal Pb; heavy metal lead; hippocampal; hypothalamic pituitary axis; improved; in utero; in utero exposure; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; intra-uterine environmental exposure; intrauterine environmental exposure; major depression; maternal depression; multidisciplinary; neonatal animal; neurobehavior; neurobehavioral; neurogenesis; newborn human (0-6 weeks); prenatal; prenatal exposure; prenatally exposed; rapid eye movement sleep; repair; repaired; reuptake; serotonin reuptake inhibitor; social disturbance; sonogram; sonography; sound measurement; study design; transmission process; ultrasound; ultrasound imaging; ultrasound scanning; unborn; youngster",Fetal and Neonatal Neurobehavior and Prenatal Antidepressant Exposure,,78033,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,3,648723,
7903394,R01,MH,5,,03/01/2010,02/28/2011,PA-07-070,5R01MH078049-03,,NIMH:338639;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"TAGAMETS, MALLE ANNE;",6803797;,5R01MH078049,04/08/2008,02/29/2012,"Affect; Area; Attention; Automated Indexing; Behavioral; Behavioral Model; Biological; Brain; Clinical Trial Overviews; Cognitive; Cognitive deficits; Collection; Complex; Data; Data Banks; Data Bases; Data Pooling; Data Poolings; Databank, Electronic; Databanks; Database, Electronic; Databases; Delusions; Dependence; Disease; Disease Marker; Disorder; Dysfunction; Early Diagnosis; Encephalon; Encephalons; Environment; FLR; Failure (biologic function); Family member; First Degree Relative; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hallucinations; Image; Indexing, Automated; Indexing, Computer-based; Inferior; Interview; Language; Language Disorders; Language disability; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Maintenance; Maintenances; Measures; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Meta-Analyses; Meta-Analysis; Methods; Modeling; Monitor; Nature; Nervous System, Brain; Outcome; Paranoia; Paranoid Disorders; Pattern; Performance; Persons; Phrases (PT); Phrases [Publication Type]; Physiologic; Physiological; Physiopathology; Population; Process; Production; Public Health; Relative; Relative (related person); Retrieval; Review Literature; Risk; Sampling; Schizophrenia; Schizophrenic Disorders; Semantic; Semantics; Sensory; Severities; Short-Term Memory; Societies; Speech; Staging; Symptoms; System; System, LOINC Axis 4; TXT; Testing; Text; To specify; Update; Visual; behavior measurement; behavioral measure; behavioral measurement; biological systems; biomarker; clinical data repository; clinical data warehouse; cohort; data repository; dementia praecox; disease risk; disease/disorder; disorder risk; early detection; executive control; executive function; fMRI; failure; falls; frontal cortex; frontal lobe; healthy volunteer; imaging; indexing; language deficit; language processing; pathophysiology; phrases; public health medicine (field); relational database; response; schizophrenic; semantic processing; theories; working memory",Brain Correlates of Executive Function during Semantic Retrieval in Schizophrenia,,78049,LCOM,Language and Communication Study Section,,3,338639,
7766260,R01,MH,5,,02/01/2010,01/31/2011,PA-05-019,5R01MH078052-03,,NIMH:769011;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,HANOVER,UNITED STATES,PSYCHIATRY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"BARTELS, STEPHEN J;",1895110;,5R01MH078052,05/31/2007,01/31/2013,"21 year old; 21+ years old; Accident and Emergency department; Acute; Address; Adult; Affective Disorders; Age; Aged 65 and Over; Behavior; Biological; Blood Serum; Clinical; Communities; Comorbidity; Consumer Preferences; Development; Diagnostic; Diet; Diet Modification; Diet good; Disease; Disorder; Drugs; Education; Educational Materials; Educational aspects; Effectiveness; Elderly; Elderly, over 65; Emergency Department; Emergency room; Emotional Depression; Equipment; Exercise; Exercise, Physical; Feedback; General Population; General Public; Goals; HOSP; Health; Health Benefit; Health Club; Health Instruction; Health Promotion; Health Promotion and Education; Health Promotion and Instruction; Health Promotion and Training; Health Services; Health Status; Health Training; Health Tutoring; Health behavior; Health behavior change; Health education; Healthy diet; Home; Home environment; Hospitalization; Human, Adult; Incentives; Individual; Intervention; Intervention Strategies; Investigators; Laboratories; Learning; Length of Life; Level of Health; Life Expectancy; Life Style; Lifestyle; Lipids; Longevity; Maintenance; Maintenances; Measures; Medical; Medication; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Mentors; Metabolic; Modeling; Modifications, Dietary; Mood Disorders; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Obesity; Outcome; Participant; Patient Self-Report; Performance; Personal Satisfaction; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physical Fitness; Pilot Projects; Populations at Risk; Preferences, Consumer; Prevalence; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychological reinforcement; Public Health; Public Sector; Randomized; Randomized Controlled Trials; Recommendation; Reinforcement; Reinforcement (Psychology); Research Personnel; Researchers; Salutogenesis; Schizophrenia; Schizophrenic Disorders; Self Efficacy; Self-Report; Serum; Services; Shapes; Site; Symptoms; Symptoms of depression; Testing; Training; Triacylglycerol; Triglycerides; Unspecified Mental Disorder; Visit; Walking; Weight; adiposity; adult human (21+); advanced age; base; behavior change; compare effectiveness; corpulence; corpulency; corpulentia; dementia praecox; depressive; depressive symptoms; design; designing; diet and exercise; disease/disorder; drug/agent; elders; fitness; geriatric; health belief; health care service; health training; health-related belief; improved; incentive; inducement; interventional strategy; late life; later life; life span; lifespan; meetings; mental illness; novel; obese; obese people; obese person; obese population; older adult; older person; pilot study; primary outcome; programs; psychological disorder; psychosocial; public health medicine (field); randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; schizophrenic; secondary outcome; sedentary; senior citizen; serious mental illness; severe mental illness; social; trial comparing; twenty-one year old; waist circumference; well-being",Health Promotion and Fitness for Younger and Older Adults With SMI,,78052,PRDP,Psychosocial Risk and Disease Prevention Study Section,,3,769011,
7758705,R01,MH,5,,02/01/2010,01/31/2011,PA-07-092,5R01MH078165-03,,NIMH:929381;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ANN ARBOR,UNITED STATES,PSYCHOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LORD, CATHERINE ;",1880306;,5R01MH078165,02/01/2008,01/31/2013,"0-11 years old; Adaptive Behaviors; Address; Age; Age-Months; American Psychological Association; Analysis, Data; Appointment; Arbitrating; Arbitration; Articulation; Authorship; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Award; Behaviors, Adaptive; Budgets; C 1 Esterase; C1 Esterase; C1 s; C1s; Categories; Child; Child Youth; Children (0-21); Clinical; Clinical Trials Data Monitoring Committees; Code; Codes of Ethics; Coding System; Cognitive; Collaborations; Communication; Communities; Complement 1 Esterase; Complement 1s; Complement component C1s; Computers; Confidence Intervals; Crossover Design; Data; Data Analyses; Data Banks; Data Bases; Data Monitoring Committees; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Designs, Cross-Over; Development; Diagnosis; Diagnostic; E-Mail; Early identification; Early treatment; Education; Educational aspects; Educational process of instructing; Electronic Mail; Electronics; Elements; Email; Ensure; Environment; Ethical Codes; Evaluation; FTP; Family; Florida; Funding; Generalized Growth; Grant; Growth; Health; Hour; Housing; Human, Child; Individual; Internet; Intervention; Intervention Strategies; Intervention Studies; Investigation; Investigators; Joints; Kanner's Syndrome; Language; Life; Linear Models; Link; Mails; Measurement; Measures; Michigan; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Research Council; National Research Council (U.S.); Outcome; Outcome Measure; Parents; Pattern; Phone; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Publications; Randomized; Recruitment Activity; Regulation; Relative; Relative (related person); Research; Research Personnel; Research Resources; Researchers; Resources; Rights; Role; Running; SCHED; Safety Monitoring Boards; Sample Size; Sampling; Schedule; Scientific Publication; Screening procedure; Secure; Self-Help Groups; Severities; Site; Social Interaction; Staging; Support Groups; Symptoms; Teaching; Technology; Telephone; Time; TimeLine; Tissue Growth; Toddler; Training; United States National Institute of Mental Health; Universities; Update; Video Recording; Videorecording; Videotape; WWW; Work; Writing; adaptation behavior; adaptive behavior; autism spectrum disorder; base; children; clinical data repository; clinical data warehouse; compare effectiveness; conference; cost efficient; data repository; design; designing; digital; dissemination research; effective intervention; evidence base; experience; financial incentive; formycin 5'-triphosphate; formycin A 5'-triphosphate; formycin triphosphate; human subject protection; improved; interest; interventional strategy; meetings; ontogeny; programs; randomisation; randomization; randomly assigned; recruit; relational database; response; screening; screenings; self help organization; sharing data; skills; social communication; social role; symposium; video recording system; web; web site; world wide web; youngster",2/2-Effects of Parent-Implemented Intervention for Toddlers with Autism Spectrum,,78165,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,3,929381,
7761731,R01,MH,5,,02/01/2010,01/31/2011,PAR-07-155,5R01MH080066-03,,NIMH:650296;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"GOLD, JAMES M.;",2095067;,5R01MH080066,02/25/2008,01/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Accounting; Address; Adverse effects; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Area; Basal Ganglia; Basal Nuclei; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Behavioral Paradigm; Cell Communication and Signaling; Cell Signaling; Chronic Schizophrenia; Clinical; Clinical Research; Clinical Study; Cognition; Cognitive; Computer Simulation; Computerized Models; Data; Decision Making; Dopamine; Drugs; Dysfunction; Exposure to; FLR; Failure (biologic function); Feedback; Functional disorder; Goals; Hydroxytyramine; Impairment; Inferior; Intracellular Communication and Signaling; Lateral; Lead; Learning; Lesion; Major Tranquilizers; Mathematical Model Simulation; Mathematical Models and Simulations; Medial; Mediating; Medication; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Modeling; Models, Computer; Motivation; Nature; Negative Reinforcements; Neurobiology; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neurosciences; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Plant Roots; Positive Reinforcements; Prefrontal Cortex; Process; Programs (PT); Programs [Publication Type]; Psychological reinforcement; Punishment; Reinforcement; Reinforcement (Psychology); Reinforcements, Negative; Reinforcements, Positive; Relative; Relative (related person); Research Design; Rewards; Role; Sampling; Schizophrenia; Schizophrenic Disorders; Series; Short-Term Memory; Side; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Simulation, Computer based; Structure; Study Type; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Therapeutic; Tranquilizing Agents, Major; Translating; Translatings; Treatment Side Effects; Universities; Update; Work; base; behavioral control; biological signal transduction; computational framework; computational modeling; computational models; computational simulation; computational studies; computer based models; computer framework; computer studies; computerized modeling; computerized simulation; dementia praecox; design; designing; disability; dopamine system; drug/agent; experience; experiment; experimental research; experimental study; failure; frontal cortex; frontal lobe; habit learning; heavy metal Pb; heavy metal lead; in silico; language translation; motivational processes; neurobiological; novel; pathophysiology; programs; research study; response; reward processing; role model; root; schizophrenic; side effect; simulation; social role; study design; surgery; therapy adverse effect; treatment adverse effect; virtual simulation; working memory",Clinical and Computational Studies of Dopamine Function in Schizophrenia,,80066,APDA,Adult Psychopathology and Disorders of Aging Study Section,,3,650296,
7797309,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH080323-02,,NIMH:290886;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,JOHNSON CITY,UNITED STATES,PHARMACOLOGY,01,051125037,US,TN,37614,EAST TENNESSEE STATE UNIVERSITY,"ZHU, MENG-YANG ;",7370942;,5R01MH080323,04/01/2009,01/31/2013,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; ADRGND; Acetyl-CoA-chloramphenicol 3-O-acetyltransferase; Activities of Daily Living; Activities of everyday life; Adrenal Glands; Adrenals; Affect; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Area; Band Shift Mobility Assay; Bandshift Mobility Assay; Behavior; Binding; Binding (Molecular Function); Biological; Brain; Brain region; CAT Enzyme; CAT I; CAT II; CAT III; CRE Binding Protein; CREB; CREB Protein; Carrier Proteins; Catecholamines; Cell Line; Cell Lines, Strains; Cell model; CellLine; Cells; Cellular model; Chemotherapy-Hormones/Steroids; Chloramphenicol Acetyl Transferase; Chloramphenicol Acetyltransferase; Chloramphenicol O-Acetyltransferase; Chloramphenicol Transacetylase; Chronic; Chronic stress; Cognition; Common Rat Strains; Cornu Ammonis; Corticosteroid Receptors; Corticosterone; Cultured Cells; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; DNA Alteration; DNA mutation; Data; Depression; Development; Disease; Disorder; Dose; Drug Therapy; Dysfunction; EC 2.3.1.28; Electrophoretic Mobility Shift Assay; Emotional Depression; Emotions; Encephalon; Encephalons; Endocrine Gland Secretion; Exposure to; Functional disorder; Gene Alteration; Gene Mutation; Gene Transcription; Genes; Genes, Regulator; Genetic Transcription; Genetic mutation; Glucocorticoids; Goals; HPA; Hippocampus; Hippocampus (Brain); Hormones; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; In Vitro; Knockout Mice; Lead; Levarterenol; Levonorepinephrine; Link; Locus Coeruleus; Major Depressive Disorder; Mammals, Rats; Measurement; Measures; Mediating; Memory; Mental Depression; Mental disorders; Mental health disorders; Messenger RNA; Methods and Techniques; Methods, Other; Mice, Knock-out; Mice, Knockout; Microdialysis; Mobility Shift Assay; Modeling; Molecular; Molecular Interaction; NET protein, neuronal; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Nervous System, Pituitary; Neural Cell; Neurobiology; Neurocyte; Neuronal Transmission; Neurons; Noradrenaline; Norepinephrine; Nucleus Pigmentosus Pontis; Null Mouse; Patients; Pb element; Pharmacotherapy; Phase; Physiopathology; Pituitary; Pituitary Gland; Precipitation; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Preventive; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Psychiatric Disease; Psychiatric Disorder; Psychosocial Stress; RNA Expression; RNA, Messenger; Rat; Rattus; Regulation; Regulator Genes; Reporter; Research; Response Elements; Rodent Model; Role; Sequence Alteration; Signal Pathway; Stress; Structure; Structure of locus ceruleus; Suspension, Tail; Swimming; Sympathins; Symptoms of depression; Synapses; Synaptic; Synaptic Cleft; System; System, LOINC Axis 4; Tail Suspension; Techniques; Testing; Therapeutic Effect; Therapeutic Glucocorticoid; Therapeutic Hormone; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Transcriptional Regulatory Elements; Transgenes; Transmission; Transport Proteins; Transporter Protein; Unspecified Mental Disorder; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; amygdaloid nuclear complex; base; blue nucleus; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; cultured cell line; daily living functionality; depressive; depressive symptoms; disease/disorder; extracellular; functional ability; functional capacity; gel shift assay; gene product; heavy metal Pb; heavy metal lead; hippocampal; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; improved; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; locus ceruleus structure; mRNA; major depression; mental illness; neurobiological; neuronal; neurotransmission; noradrenaline transporter; noradrenergic; norepinephrine transporter; norepinephrine transporter protein; novel; pathophysiology; psychological disorder; regulatory gene; slc6a2 protein; slc6a5 protein; social; social role; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5; suprarenal gland; theories; trans acting element; transmission process; uptake",Neurobiological Correlates of Stress and Norepinephrine Transporter," Project Narrative:  Chronic stress is one possible cause of major depression. During stress, there is an increase in release of hormones such as corticosterone. These hormones affect many brain areas functionally and structurally. Norepinephrine transporter is a key protein in the brain and is related to the function of the noradrenergic system which controls emotion, memory and cognition. The goal of this project is to elucidate the regulatory effects of stress, stress hormones on the norepinephrine transporter, as well as underlying molecular mechanisms. A rat stress model of chronic social defeat and the cell models treated with corticosterone will be used. The results will improve our understanding of causal roles of stress and noradrenergic dysfunction in depression, and ultimately may lead to novel pharmacotherapies for this disorder.",80323,NMB,Neurobiology of Motivated Behavior Study Section,,2,290886,
7772380,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH080898-03,,NIMH:592584;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,IOWA CITY,UNITED STATES,PSYCHIATRY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"PHILIBERT, ROBERT A;",1913949;,5R01MH080898,07/01/2008,01/31/2013,"0-11 years old; 11 year old; 21+ years old; 5HT transporter; 5HTT protein; AOD use; Active Follow-up; Address; Adult; Adult Children; Adult Daughters; Adult Sons; Affect; African American; Afro American; Afroamerican; Aggregated Data; Aggregation, Data; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; American; Anxiety; Applications Grants; Articulation; Attention; Behavior; Behavioral; Behavioral Genetics; Biocompatible Materials; Biological; Biomaterials; Black Populations; Black or African American; Blood; Blood Pressure, High; Blood Sample; Blood specimen; Candidate Disease Gene; Candidate Gene; Care Givers; Caregivers; Caring; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Censuses; Characteristics; Child; Child Youth; Children (0-21); Cognitive; Collaborations; Collection; Communities; Companions; Complex; Consent; DNA; DSM-IV; DSM4; Data; Data Aggregation; Data Collection; Demographic Factors; Deoxyribonucleic Acid; Depression; Development; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Disease; Disorder; Distress; Economic Income; Economical Income; Emergent Technologies; Emerging Technologies; Emotional well being; Environment; Environmental Factor; Environmental Risk Factor; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; EtOH drinking; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; European; Event; Exclusion; Family; Family and Community Health Study; Feels well; Female; Foundations; Funding; Future; Gene variant; Genes; Genetic; Genetic Determinants of Behavior; Genetic Diversity; Genetic Markers; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic Variation; Genetic analyses; Genetics, Behavioral; Genotype; Gibbons; Grant; Grant Proposals; Grants, Applications; Haplotypes; Head and Neck, Saliva; Health; History; Household; Human, Adult; Human, Child; Hylobates; Hylobates Genus; Hypertension; Income; Individual; Inherited Predisposition; Inherited Susceptibility; Institution; Interview; Investigation; Investigators; Iowa; Joints; Lead; Length of Life; Life; Life Cycle; Life Cycle Stages; Link; Literature; Longevity; Measures; Mediating; Mental Depression; Mental Health; Mental Hygiene; Mental well-being; Method LOINC Axis 6; Methodology; Methods; Minisatellite Repeats; Minisatellites; Modeling; Models, Theoretic; Molecular; Molecular Genetic; Molecular Genetics; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neighborhoods; Neuroses; Neurotic Disorders; Nicotine; Nomascus; Normal mental condition; Normal mental state; Normal psyche; Obesity; Occidental; Offspring, Adult; Outcome; Parents; Participant; Patient Self-Report; Pb element; Personality; Phase; Phenotype; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Study; Poverty; Prevention; Primary Care; Primary Health Care; Primary Healthcare; Principal Investigator; Procedures; Process; Psychological Health; Psychological Well Being; Psychologist; Psychoneuroses; Psychopathology; Psychosocial Assessment and Care; Psychosocial Factor; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Qualifying; R01 Mechanism; R01 Program; RPG; Recording of previous events; Recruitment Activity; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Risk; Role; SNP genotyping; Saliva; Sampling; Self-Report; Sense of well-being; Shapes; Simple Repetitive Sequence; Single-Parent Family; Source; Staging; Statistical Methods; Stratification; Stress; Structure; Substance Use Disorder; Survival Analyses; Survival Analysis; Symphalangus; Testing; Theoretical model; Thinking; Thinking, function; Time; United States National Institute of Mental Health; VNTR; VNTR Loci; VNTR Region; VNTR Sequences; Variable Number of Tandem Repeats; Variable Tandem Repeats; Variant; Variation; Variation (Genetics); Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Well in self; Woman; Work; abnormal psychology; adiposity; adult human (21+); adult youth; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic variant; base; behavior genetics; black American; case control; children; corpulence; corpulency; corpulentia; disease/disorder; eleven year old; environment effect on gene; environmental risk; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; experience; family structure; follow-up; gene environment interaction; genetic analysis; genetic etiology; genetic mechanism of disease; genetic vulnerability; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; inner city; innovate; innovation; innovative; insight; interest; life course; life span; lifespan; male; member; men; men's; mid life; mid-life; middle age; middle aged; midlife; neurotic; neuroticism; obese; obese people; obese person; obese population; polymorphism; primary outcome; psychologic; psychological; psychological wellness; psychosocial; psychosocial assessment; psychosocial care; psychosocial studies; psychosocial support; psychosocial variables; public health relevance; racism; recruit; repository; resilience; response; rural area; self wellness; serotonin transporter; social role; sodium-dependent serotonin transporter; substance use; success; trait; translational study; white race; young adult; youngster",Examination of Genetic and GxE Effects in the Family and Community Health Studies,,80898,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,3,592584,
7789629,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH080910-02,,NIMH:386250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,PSYCHIATRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"FEIFEL, DAVID ;",1864176;,5R01MH080910,03/20/2009,01/31/2014,"1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-; 5HT; Abbreviations; Accounting; Affinity; Agonist; Aminalon; Aminalone; Amphetamines; Animal Model; Animal Models and Related Studies; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Area; Attenuated; Blood - brain barrier anatomy; Blood-Brain Barrier; Body of uterus; Brain; Butanoic acid, 4-amino-; Bypass; Cells; Central Nervous System; Chemicals; Clinical; Clozapine; Cognitive deficits; Common Rat Strains; Complement; Complement Proteins; Corpus; Corpus Uteri; Development; Discrimination, Social; Disease; Disorder; Dopamine; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Elements; Encephalon; Encephalons; Enteramine; Exhibits; Future; GABA; Globus Pallidus; Goals; Haldol; Haloperidol; Hemato-Encephalic Barrier; Hippophaine; Hydroxytyramine; Knockout Mice; Knowledge; Laboratories; Lead; Major Tranquilizers; Mammals, Mice; Mammals, Rats; Medial; Mediating; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Microdialysis; Murine; Mus; NIH; NT1-R protein; NTR-1 protein; National Institutes of Health; National Institutes of Health (U.S.); Nerve Transmitter Substances; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurochemistry; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neuropeptides; Neurotensin; Neurotensin Receptors; Neurotransmitters; Norway; Nucleus Accumbens; Null Mouse; Pathway interactions; Pb element; Peptides; Peripheral; Pharmaceutical Resources; Population; Prefrontal Cortex; Principal Investigator; Process; Psychoses; Psychotic Disorders; Rat; Rats, Norway; Rattus; Rattus norvegicus; Receptor Protein; Receptors, Neurotensin; Relative; Relative (related person); Research; Role; Saline; Saline Solution; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Serotonin; Short-Term Memory; Site; Social Discrimination; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Therapeutic Effect; Tranquilizing Agents, Major; Transmission; United States National Institutes of Health; Uterine Body; Visual attention; Work; base; brain pathway; computer based prediction; dementia praecox; design; designing; disease/disorder; drug development; drug efficacy; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; genetic manipulation; heavy metal Pb; heavy metal lead; improved; interest; intraperitoneal; mimetics; model organism; neurochemistry; neurotensin type 1 receptor; novel; overexpression; pallidum; pathway; postsynaptic; pre-clinical; preclinical; predictive modeling; prepulse inhibition; processing speed; public health relevance; receptor; research study; response; schizophrenic; social; social role; subcutaneous; theories; therapeutic target; tool; transmission process; working memory",Neurotensin-1 Receptor as a Therapeutic Target for Schizophrenia," NARRATIVE  Schizophrenia is a debilitating disorder for which current treatments are unsatisfactory. We propose studies aimed at investigating the possibility of developing novel treatments that target neurotensin, a natural chemical in the brain. The proposed experiments may help lead to completely novel and superior treatments for schizophrenia.",80910,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,2,386250,
7816833,R01,MH,5,,02/01/2010,01/31/2011,PA-07-085,5R01MH081023-02,,NIMH:369635;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN DIEGO,UNITED STATES,PSYCHOLOGY,53,073371346,US,CA,92182,SAN DIEGO STATE UNIVERSITY,"MUELLER, RALPH-AXEL ;",6569854;,5R01MH081023,05/01/2009,01/31/2014,"0-11 years old; Affect; Age; Anatomic; Anatomical Sciences; Anatomy; Anisotropy; Architecture; Auditory; Auditory Cortex; Auditory area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavioral; Biochemical; Brain; Cerebral cortex; Cerebrum; Child; Child Youth; Childhood; Children (0-21); Cognition; Cognitive; Complex; Consensus; Data; Defect; Development; Diagnostic; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Dysfunction; Encephalon; Encephalons; Engineering / Architecture; Event; Fiber; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Generalized Growth; Genes; Genetic; Genetic Risk; Growth; Health; Human, Child; Image; Impairment; Individual; Inferior; Kanner's Syndrome; Language; Left; Link; Literature; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods and Techniques; Methods, Other; Modeling; Motor; Motor Cortex; NMR Imaging; NMR Tomography; Nervous; Nervous System, Brain; Neurocognitive; Neurodevelopmental Disorder; Neurological Development Disorder; Neuropsychologic Tests; Neuropsychological Tests; Noise; Nuclear Magnetic Resonance Imaging; Participant; Pathogenesis; Pathologic Processes; Pathological Processes; Pathology; Pathway interactions; Performance; Phenotype; Physiologic; Physiological; Physiopathology; Play; Population; Process; Process Measure; Property; Property, LOINC Axis 2; Public Health; Radial; Research; Role; Sampling; Science of Anatomy; Semantic; Semantics; Sensory; Series; Site; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Time; Tissue Growth; Variant; Variation; Visual; Zeugmatography; anatomy; autism spectrum disorder; behavioral impairment; children; design; designing; diffusion tensor imaging; disease/disorder; endophenotype; experiment; experimental research; experimental study; fMRI; frontal cortex; frontal lobe; imaging; insight; neural; neuropathology; neuropsychological; ontogeny; pathophysiology; pathway; pediatric; public health medicine (field); public health relevance; relating to nervous system; research study; social role; substantia alba; white matter; youngster",Linking Local Activity and Functional Connectivity in Autism," Narrative Autism is a pediatric health issue of growing urgency. Genetic approaches require the identification of biologically defined subtypes (endophenotypes), to which this project will contribute by examining links between local cortical organization, brain connectivity, and cognition in children with autism, using several types of magnetic resonance imaging.",81023,DBD,Developmental Brain Disorders Study Section,,2,369635,
7765523,R01,MH,5,,12/01/2009,11/30/2010,PA-07-070,5R01MH081049-02,,NIMH:479299;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PSYCHIATRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"FRAZIER, STACY L;",6946868;,5R01MH081049,02/05/2009,11/30/2012,"0-11 years old; Age; Behavior; Chicago; Child; Child Behavior; Child Mental Health; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Communities; Consultations; Data; Development; Effectiveness; Funding; Goals; Human, Child; Intervention; Intervention Strategies; Life; Link; Literature; Manuals; Measures; Mental Health; Mental Hygiene; Mission; Modeling; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Outcome; PROV; Parents; Patient Self-Report; Perception; Poverty; Process; Programs (PT); Programs [Publication Type]; Provider; Psychological Health; Randomized; Reporting; Research; Research Resources; Resources; Risk; Self-Report; Services; Site; Social Environment; Structure; Testing; Training; United States National Institute of Mental Health; Work; after-school program; child mental health service; children; clinical investigation; experience; health practice; improved; intervention development; interventional strategy; meetings; programs; public health relevance; randomisation; randomization; randomly assigned; response; satisfaction; social; social climate; social context; socioenvironment; theories; therapy development; treatment development; youngster",Organizational Context and Children's Mental Health in Urban After School Program," The proposed study will examine relationships among organizational features of after school programs, child and parent reports of program experiences, and children's behavior toward the further development of an intervention to impact on the ability of after school programs to promote children's adaptive functioning. The study will be conducted at 84 organized after school programs directed by the Chicago Park District. This application is the next step in a program of research that examines the capacity of publicly-funded after-school programs to promote children's mental health in urban, poor communities.",81049,SRNS,Mental Health Services in Non-Specialty Settings,,2,479299,
7769456,R01,MH,5,,02/01/2010,01/31/2011,PAS-07-192,5R01MH081060-03,,NIMH:353250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DALLAS,UNITED STATES,PSYCHIATRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"MONTEGGIA, LISA M;",3123061;,5R01MH081060,04/15/2008,01/31/2013,"2(1H)-Pyrimidinone, 4-amino-; Active Follow-up; Address; Affect; Ammon Horn; Area; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome; Binding; Binding (Molecular Function); Cerebroatrophic Hyperammonemia; Complement; Complement Proteins; Complex; Cornu Ammonis; Cytosine; Disease; Disorder; Drugs; Electrophysiology; Electrophysiology (science); Frequencies (time pattern); Frequency; Gait; Gene Down-Regulation; Gene Expression; Gene Targeting; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Grant; HD1; HDAC; HDAC Agent; HDAC Proteins; HDAC1; HDAC1 gene; HDAC2; HDAC2 gene; Hand; Hippocampus; Hippocampus (Brain); Histone Deacetylase; Histone Deacetylase Inhibitor; Histone deacetylase inhibition; Histones; Individual; Knock-out; Knockout; Link; Macromolecular Protein Complexes; Mammals, Mice; MeCP-2 protein; MeCP2; MeCP2 protein; Mediating; Medication; Mental Retardation; Methods; Methyl CpG Binding Protein 2; Methyl CpG binding protein (MeCP2); Methyl CpG binding protein MeCP2; Methyl-CpG binding protein 2; Methyl-CpG-Binding Protein 2; Methyl-DNA binding protein MECP2; Mice; Molecular; Molecular Interaction; Movement; Multiprotein Complexes; Murine; Mus; Mutation; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neurodevelopmental Disorder; Neurologic; Neurological; Neurological Development Disorder; Neuronal Transmission; Neurons; Neurophysiology / Electrophysiology; Optical Methods; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Problem behavior; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA Expression; RPD3; RPD3L1; Regulation; Relative; Relative (related person); Rett Disorder; Rett Syndrome; Rett syndrome (RS, RTS); Role; Symptoms; Synapses; Synaptic; Synaptic Transmission; Synaptic Vesicles; Synaptic plasticity; Syndrome; Targetings, Gene; Transcription; Transcription Corepressor; Transcription Repression; Transcription Repressor; Transcription Repressor/Corepressor; Transcription, Genetic; Transcriptional Corepressor; Transcriptional Repression; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transmission; Work; YAF1; behavioral problem; body movement; disease-causing mutation; disease/disorder; drug/agent; experiment; experimental research; experimental study; follow-up; gene product; gene repression; genome mutation; girls; hippocampal; insight; interest; male; methyl-CpG (cytosine-guanine dinucleotide) binding protein 2; neuronal; neurotransmission; overexpression; public health relevance; research study; social role; synapse formation; synapse function; synaptic depression; synaptic function; synaptogenesis; trafficking; transmission process",MeCP2 Dependent Transcriptional Repression & Neurotransmission,,81060,ZRG1,Special Emphasis Panel,,3,353250,
7789531,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH081817-02,,NIMH:334850;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,NEUROSCIENCES,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"RINAMAN, LINDA M;",1902013;,5R01MH081817,03/20/2009,01/31/2014,"21+ years old; 3,4-Dihydroxyphenethylamine, ascorbate[{..}]oxygen oxidoreductase (beta-hydroxylating); Acute; Address; Adult; Affect; Animal Experimental Use; Animal Experimentation; Animal Research; Anxiety; Assay; Attention; Aujeszky's Disease Virus; Aujeszkys Disease Virus; Behavior; Behavioral; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Blood Sample; Blood specimen; Brain; Brain Stem; Brainstem; Care Givers; Caregivers; Caring; Cell Communication and Signaling; Cell Signaling; Common Rat Strains; Corticosterone; DBH; Data; Development; Disease; Disorder; Dopamine beta-Hydroxylase; Dopamine-beta-monooxygenase; EGFP protein; Emotional; Emotional Stress; Emotions; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Event; Exposure to; Fear; Female; Fishes; Fixatives; Fore-Brain; Forebrain; Fright; Growth and Development; Growth and Development function; Health; Herpesvirus 1 (alpha), Suid; Herpesvirus 1, Suid; Herpesvirus Suis; History; Hormonal; Human; Human, Adult; Human, General; Hypothalamic structure; Hypothalamus; Individual; Infant; Intracellular Communication and Signaling; Label; Laboratory Rat; Learning; Lentiviral Vector; Lentivirus Vector; Life; Life Experience; Link; Lithium Chloride; Lithium chloride (LiCl); Mammals, Rats; Man (Taxonomy); Man, Modern; Methods; Modeling; Monitor; Mothers; Motivation; Motor; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurocyte; Neurons; Odors; Outcome; Pathway interactions; Physiologic; Physiological; Plasma; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Price; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prosencephalon; Pseudorabies virus; Rat; Rat, Laboratory; Rattus; Recording of previous events; Reporting; Research; Reticuloendothelial System, Serum, Plasma; Screening procedure; Sensory; Septic Toxemia; Serum, Plasma; Sex Characteristics; Sex Differences; Sex Maturation; Sexual Maturation; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Stress; Stress, Emotional; Stressful Event; Suid Herpesvirus 1; Swine Herpesvirus 1; Testing; Toxemia; Variant; Variation; Visceral; Weaning; Work; acute stress; adult human (21+); adult youth; animal facility; biological signal transduction; comparative; density; developmental plasticity; disease/disorder; dopamine beta hydroxylase; early experience; emotional expression; enhanced green fluorescent protein; experience; experiment; experimental research; experimental study; expression of emotion; gender difference; hypothalamic; insight; male; maternal separation; neural; neural circuit; neural circuitry; neural control; neural regulation; neuronal; neuroregulation; noradrenergic; offspring; pathway; postnatal; pricing; pup; relating to nervous system; research study; response; restraint; restraint stress; screening; screenings; sensory feedback; sex; sexual dimorphism (noncellular); showing emotion; stressor; tissue fixing; young adult",Early Life Experience Shapes Visceral Circuits," Project Narrative Interactions between infants and their mother (or primary caregiver) are critical for normal growth and development, and perturbations can disrupt physiological and behavioral functions in the offspring. The proposed research will use anatomical and physiological methods in rats to test the hypothesis that the influence of early life events on later responses to stress and emotional events is linked to developmental plasticity of circuits that provide visceral sensory feedback to the brain and generate emotional expression.",81817,NMB,Neurobiology of Motivated Behavior Study Section,,2,334850,
7767662,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH081860-03,,NIMH:321436;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PORTLAND,UNITED STATES,OBSTETRICS & GYNECOLOGY,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"MAYLIE, JAMES G;",1889791;,5R01MH081860,07/01/2008,01/31/2013,"A kinase anchoring protein; AKAP; AMPA Receptors; Abscission; Acquired brain injury; Action Potentials; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Animal Model; Animal Models and Related Studies; Apamin; Back; Behavioral; Binding; Binding (Molecular Function); Biochemical; Brain; Brain Injuries; Calcineurin; Calcium-Activated Potassium Channel; Cell Body; Cell Communication and Signaling; Cell Signaling; Chemicals; Chemosensitization; Chemosensitization/Potentiation; Clathrin; Co-Immunoprecipitations; Cognition Disorders; Complex; Cornu Ammonis; Coupled; Coupling; Cyclic AMP-Dependent Protein Kinases; DLG1; DLG1 gene; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dendritic Spines; Dephosphin; Development; Dorsum; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dynamin; EPSP; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Endocytosis; Endosomes; Excision; Excitatory Postsynaptic Potentials; Extirpation; FLR; Failure (biologic function); Family; Feedback; Glutamate Receptor; HDLG; Hippocampus; Hippocampus (Brain); Image; Immunoelectron Microscopy; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Ions; K+ Channels, Ca2+-Activated; K+ Channels, Calcium-Activated; Label; Learning; Long-Term Potentiation; Mammals, Mice; Mediating; Membrane; Membrane Channels; Memory; Mice; Mice, Transgenic; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Molecular; Molecular Interaction; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; PKA; PP2B; Pathology; Pathway interactions; Physiologic; Physiological; Population; Potentiation; Primary Senile Degenerative Dementia; Property; Property, LOINC Axis 2; Protein Kinase A; Protein Phosphatase-2B; Receptors, AMPA; Receptors, N-Methylaspartate; Receptosomes; Recycling; Removal; Research; Role; SAP97; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Spinal Column; Spine; Structure; Surgical Removal; Synapses; Synaptic; Synaptic plasticity; Testing; Therapeutic Intervention; Transgenic Mice; Trauma; VESCL; Vertebral column; Vesicle; Whole-Cell Recordings; aging brain; backbone; base; biological signal transduction; brain damage; brain lesion (from injury); cAMP-Dependent Protein Kinases; cell body (neuron); cognitive disease; cognitive disorder; dementia of the Alzheimer type; dendrite spine; density; experience; experiment; experimental research; experimental study; failure; hippocampal; imaging; in vivo; information processing; intervention therapy; late endosome; membrane structure; model organism; neural cell body; neuronal; neuronal cell body; normal aging; overexpression; pathway; postsynaptic; primary degenerative dementia; public health relevance; research study; resection; senile dementia of the Alzheimer type; social role; soma; success; trafficking",SK channels: Roles and mechanisms for dendritic excitability and plasticity,,81860,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,3,321436,
7761304,R01,MH,5,,12/01/2009,11/30/2010,PA-07-070,5R01MH081917-02,,NIMH:368300;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BIRMINGHAM,UNITED STATES,PHYSIOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"WANG, QIN ;",8543762;,5R01MH081917,01/27/2009,11/30/2013,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; AD/HD; ADHD; Abbreviations; Absence of pain sensation; Absence of sensibility to pain; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adrenaline; Adrenergic Receptor; Adrenoceptors; Agonist; Antibodies; Anxiety; Arrestins; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-; Biochemical; Blood Pressure, High; Blood Pressure, Low; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Clinic; Clinical; Clonidine; Cognition; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Cyclic AMP-Dependent Protein Kinases; Data; Depression; Disease; Disorder; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Editorial Comment; Editorial Comment (PT); Endocytosis; Epi; Epinephrine; Exhibits; Family; Feels no pain; Future; G Protein-Complex Receptor; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-Proteins; GPCR Signaling; GTP-Binding Proteins; GTP-Regulatory Proteins; Genetic Models; Goals; Guanfacine; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Hypertension; Hypotension; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kinetic; Kinetics; Klofenil; Knock-in; Knock-in Mouse; Knockout Mice; Knowledge; Ligands; Linear Models; Mammals, Mice; Mediating; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; Mice; Mice, Knock-out; Mice, Knockout; Models, Genetic; Molecular; Murine; Mus; N-terminal; NH2-terminal; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; No sensitivity to pain; Null Mouse; PKA; Pain; Painful; Pathogenesis; Perception; Pharmacology; Phosphorylation; Physiologic; Physiological; Play; Position; Positioning Attribute; Protein Kinase A; Protein Phosphorylation; Proteins; Published Comment; Receptor Mediated Signal Transduction; Receptor Protein; Receptor Signaling; Receptors, Epinephrine; Regulation; Role; Sedation procedure; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Surface; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Epinephrine; Time; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Viewpoint; Viewpoint (PT); adenoreceptor; analgesia; attention deficit hyperactive disorder; base; biological signal transduction; cAMP-Dependent Protein Kinases; desensitization; design; designing; disease/disorder; drug development; functional outcomes; gene product; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vivo; insight; interventional strategy; member; neurabin II; neuronal; novel; public health relevance; receptor; receptor coupling; response; sedation; social role; spinophilin; stoichiometry; therapeutic target; tool; trafficking; working memory",Regulation of alpha2A-adrenergic receptor signaling and trafficking by spinophili," Project Narrative G protein-coupled receptors (GPCRs) are members of the largest family of surface receptors and represent the most abundant class of therapeutic targets. The ¨2- adrenergic receptor (¨2AR) subfamily mediates a wide range of critical physiological/pharmacological responses which include lowering blood pressure, evoking sedation, reducing pain perception, and improving working memory. Using genetic models and molecular and cellular strategies, our studies aim to understand how ¨2AAR functions are tightly regulated by the interacting protein, spinophilin. Information obtained from our studies will advance our understanding of endogenous cellular mechanisms underlying ¨2AAR functions, and thus provide novel insight into therapeutic strategies aimed at the treatment of attention deficit and hyperactivity disorder (ADHD), depression, hypertension and other clinical settings where use of ¨2AR-agonists may be warranted.",81917,MNPS,Molecular Neuropharmacology and Signaling Study Section,,2,368300,
7795986,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH081935-03,,NIMH:373500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BRONX,UNITED STATES,NEUROSCIENCES,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CASTILLO, PABLO E;",6999145;,5R01MH081935,07/01/2008,01/31/2013,"Acquired brain injury; Acute; Addiction, Drug; Affect; Ammon Horn; Apoplexy; Area; Axon; Brain; Brain Injuries; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemical Dependence; Chemosensitization; Chemosensitization/Potentiation; Cloning; Cornu Ammonis; Data; Dependence, Drug; Depression; Drug Addiction; Drug Dependency; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Event; Excitatory Synapse; Future; Generations; Glutamate Receptor; Glutamates; Hippocampal Mossy Fibers; Hippocampus; Hippocampus (Brain); Idiopathic Parkinson Disease; Image; Intracellular Communication and Signaling; Investigation; Ion Channel; Ionic Channels; Ischemia; L-Glutamate; Laboratories; Learning; Lewy Body Parkinson Disease; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Mediating; Membrane Channels; Memory; Mental Depression; Methods and Techniques; Methods, Other; Modification; Molecular; Mossy Fibers, Hippocampal; Motion; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuronal Transmission; Neurons; Output; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pattern; Physiologic; Physiological; Physiology; Play; Potentiation; Predisposition; Primary Parkinsonism; Process; Protocol; Protocols documentation; Pyramidal Cells; Receptor Protein; Receptors, N-Methylaspartate; Recombinants; Regulation; Role; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Slice; Source; Stroke; Susceptibility; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Techniques; Testing; Transmission; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); Vascular Accident, Brain; Work; base; biological signal transduction; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; chronic pain; chronic painful condition; dementia praecox; design; designing; epilepsia; epileptiform; epileptogenic; experience; experiment; experimental research; experimental study; granule cell; hippocampal; imaging; inhibitor; inhibitor/antagonist; long term depression; mossy fiber; nervous system disorder; neural; neurological disease; neuronal; neurotransmission; novel; postsynaptic; prevent; preventing; public health relevance; receptor; receptor function; relating to nervous system; research study; response; schizophrenic; social role; stroke; synapse formation; synapse function; synaptic function; synaptogenesis; therapeutic development; transmission process; voltage",Activity-Dependent Synaptic Plasticity Expressed by NMDA Receptors,,81935,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,3,373500,
7761678,R01,MH,5,,02/01/2010,01/31/2011,PA-07-079,5R01MH081947-02,,NIMH:545011;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,DURHAM,UNITED STATES,PSYCHIATRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"GOLDSTON, DAVID B.;",1884198;,5R01MH081947,02/01/2009,01/31/2013,"0-11 years old; 21+ years old; Active Follow-up; Address; Adolescent; Adolescent Youth; Adolescent, Hospitalized; Adult; Affect; Anxiety; Anxiety Disorders; Area; Behavior; Behavioral; Cessation of life; Child; Child Youth; Children (0-21); Communities; Data; Daughter; Death; Depression; Depressive disorder; Diagnosis; Discipline; Distress; Drops; Drug Therapy; Emotional; Epidemiology, Family Medical History; Ethnic Origin; Ethnicity; Ethnicity aspects; Family; Family Medical History; Family Therapy; Family history of; Family psychotherapy; Feeling suicidal; HOSP; History; Hospitalization; Hospitalized Adolescent; Hostility; Human, Adult; Human, Child; Individual; Insurance Coverage; Insurance Status; Interview; Length; Light; Medical; Medical Specialities; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; Morbidity; Morbidity - disease rate; Mothers; NIH Program Announcements; Nature; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Neurosis, Depressive; PTSD; Parenting; Parenting behavior; Parents; Pathway interactions; Pattern; Pharmacotherapy; Photoradiation; Positive Reinforcements; Post-Traumatic Stress Disorders; Predictive Factor; Prevention of suicide; Program Announcement; Psychiatric Disease; Psychiatric Disorder; Psychiatric therapeutic procedure; Psychological Health; Reaction; Recommendation; Recording of previous events; Recurrence; Recurrent; Reinforcements, Positive; Relative; Relative (related person); Research; Resolution; Risk; Role; Services; Severities; Social support; Son; Specialties, Medical; Specialty; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Suicidal thoughts; Suicide; Suicide attempt; Suicide precaution; Suicide prevention; Supervision; Survivors; Symptoms; Techniques; Teen; Teenagers; Teens; Time; Unspecified Mental Disorder; Youth; Youth 10-21; acute stress; adolescent mother; adult human (21+); base; children; clinical significance; clinically significant; depressed mother; design; designing; emotional distress; experience; fatal attempt; fatal suicide; feeling distress; feeling upset; follow-up; help seeking; help-seeking behavior; high risk; intent to die; juvenile; juvenile human; maternal depression; medical specialties; meetings; mental illness; non fatal attempt; pathway; premature; prevent; preventing; psychiatric care; psychiatric therapy; psychiatric treatment; psychological disorder; response; social role; social support network; suicidal; suicidal adolescent; suicidal attempt; suicidal behavior; suicidal ideation; suicidal morbidity; suicidal thinking; suicidal youth; suicidality; suicide behavior; suicide death; suicide ideation; suicide intervention; suicide morbidity; teen mom; teen mother; teen years; teenage mom; teenage mother; thoughts about suicide; traumatic neurosis; youngster",Impact of Adolescent Suicide Attempts on Parents," Project Narrative This project will help us to understand the mental health and treatment needs of mothers of adolescents who have attempted suicide. The results of this study will help shed light on the best strategies for meeting parental needs following adolescent suicide attempts, and involving parents in their son's and daughter's treatment.",81947,SRSP,Mental Health Services in MH Specialty Settings,,2,545011,
7759187,R01,MH,5,,01/01/2010,12/31/2010,PA-07-083,5R01MH081975-02,,NIMH:649292;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN JUAN,UNITED STATES,PSYCHIATRY,,948108063,US,PR,00936,UNIVERSITY OF PUERTO RICO MED SCIENCES,"QUIRK, GREGORY J.;",1909370;,5R01MH081975,01/16/2009,12/31/2013,"21+ years old; AMPA Receptors; Adult; Affective Disorders; Animals; Anterior; Anxiety Disorders; Area; Brain; Brain imaging; Brain region; Clinical; Collaborations; Common Rat Strains; Conceptions; Data; Disease; Disorder; Dorsal; Dysfunction; Encephalon; Encephalons; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Extinction; Extinction (Psychology); FLR; Failure (biologic function); Fear; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Future; GeneHomolog; General Hospitals; Goals; Grant; Homolog; Homologous Gene; Homologue; Hospitals, General; Human; Human, Adult; Human, General; Image; Intervention; Intervention Strategies; Lead; MRI, Functional; Magnetic Resonance Imaging, Functional; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Massachusetts; Medial; Mediating; Medical Imaging, Positron Emission Tomography; Mood Disorders; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurons; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; PET; PET Scan; PET imaging; PETSCAN; PETT; PTSD; Patients; Pb element; Persons; Physiopathology; Play; Population; Positron Emission Tomography Scan; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Proton Magnetic Resonance Spectroscopic Imaging; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Puerto Rico; R21 Award; Rad.-PET; Rat; Rattus; Receptors, AMPA; Research; Rest; Rodent; Rodentia; Rodentias; Role; Schools, Medical; Science of neurophysiology; Screening procedure; Site; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Structure; Testing; Training; Training Activity; Translating; Translatings; Trauma; United States National Institute of Mental Health; addiction; adult human (21+); base; behavioral extinction; brain visualization; cingulate cortex; conditioned fear; conditioning; disease/disorder; fMRI; failure; fear conditioning; fluorodeoxyglucose; heavy metal Pb; heavy metal lead; high risk; imaging; improved; interventional strategy; language translation; medical schools; neurobiological; neuronal; neurophysiology; novel; pathophysiology; psycho-physiological; public health relevance; response; screening; screenings; social role; success; tool; translational study; traumatic neurosis",Translational Studies of Prefrontal Control of Fear Extinction," Project Narrative  Approximately 13% of the adult population in the U.S. suffer from an anxiety disorder, in which it is difficult to control or extinguish fear responses. This proposal will translate findings on the brain mechanisms of extinction from rats to humans, using neuronal recording and functional brain imaging, in order to identify neurobiological markers of extinction success or failure. If successful, this approach could lead to a screening tool for identifying persons at high risk for developing an anxiety disorder and could augment existing extinction-based therapies.",81975,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,649292,
7765537,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH082017-03,,NIMH:326025;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"SALZMAN, C. DANIEL;",1901417;,5R01MH082017,04/10/2008,01/31/2013,"Accounting; Affective; Air; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Anxiety; Appearance; Area; Association Learning; Associative Learning; Aversive Stimulus; Behavior; Behavioral; Blinking; Brain; Cell Communication and Signaling; Cell Signaling; Cognitive; Complex; Conditioning, Classical; Conditionings, Classical; Cues; Data; Disease; Disorder; Doctor of Medicine; Doctor of Philosophy; Dysfunction; Emotional; Encephalon; Encephalons; Environment; Face; Functional disorder; Future; Goals; Human; Human, General; Individual; Intracellular Communication and Signaling; Learning; Link; Liquid substance; M.D.; Mammals, Primates; Man (Taxonomy); Man, Modern; Maps; Measures; Mental disorders; Mental health disorders; Monkeys; Moods; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurosciences; Organism; Outcome; Pavlovian conditioning; Ph.D.; PhD; Physiologic; Physiological; Physiology; Physiopathology; Play; Population; Primates; Procedures; Process; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Psychological reinforcement; Punishment; Regulation; Reinforcement; Reinforcement (Psychology); Relative; Relative (related person); Research; Reversal Learning; Rewards; Role; Science of neurophysiology; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Structure; Testing; Time; Unspecified Mental Disorder; Update; Visual; Work; amygdaloid nuclear complex; base; biological signal transduction; classical conditioning; conditioning; disease/disorder; experience; eye blink; eyeblink; facial; flexibility; fluid; liquid; living system; mental illness; neural; neural circuit; neural circuitry; neural control; neural regulation; neuronal; neurophysiology; neuroregulation; pathophysiology; perceptual stimulus; physicochemical phenomena related to the senses; psychological disorder; reinforcer; relating to nervous system; response; sensory stimulus; social role; visual stimulus",Neurophysiology underlying neural representations of value,,82017,COG,Cognitive Neuroscience Study Section,,3,326025,
7789613,R01,MH,5,,02/01/2010,01/31/2011,PA-07-284,5R01MH082042-02,,NIMH:375119;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,IRVINE,UNITED STATES,ANATOMY/CELL BIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"GALL, CHRISTINE M (contact);LAUTERBORN, JULIE C;",1868414 (contact);1915527;,5R01MH082042,04/01/2009,01/31/2013,"21+ years old; AMPA Receptors; ATP[{..}]protein-tyrosine O-phosphotransferase; Actin Filaments; Actinin; Actins; Acute; Adult; Affect; Agonist; Ammon Horn; Amplaxin; Behavior; CTTN; CaM KII; CaM PK II; CaM kinase II; CaMKII; Cell Communication and Signaling; Cell Signaling; Cellular Matrix; Chemosensitization; Chemosensitization/Potentiation; Cognition; Cognitive; Complement 4; Complement component C4; Cornu Ammonis; Cttn protein; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Defect; Dendritic Spines; Disease; Disorder; Drugs; EC 2.7; EMS1; EMS1 Protein; EMS1 protein, human; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Escalante syndrome; Extracellular Matrix, Integrins; F-Actin; FLR; FMR1 Gene; Failure (biologic function); Filamentous Actin; Fmr1 gene,; Fragile X; Fragile X Mental Retardation 1 Gene; Fragile X Syndrome; Genetic Alteration; Genetic Change; Genetic defect; HEK3; Hippocampus; Hippocampus (Brain); Human, Adult; Impairment; Integrins; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Knockout Mice; Label; Lead; Learning; Length; Level of Evidence; Link; Long-Term Potentiation; Mammals, Mice; Mammary Tumor and Squamous Cell Carcinoma-Associated Protein; Martin-Bell Syndrome; Martin-Bell-Renpenning syndrome; Measures; Medication; Memory; Mental Retardation; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Microfilaments; Modeling; Morphology; Murine; Mus; Mutant Strains Mice; Mutation; Myofilaments; Neocortex; Null Mouse; PTK; Pattern; Pb element; Peptide Biosynthesis, Ribosomal; Peptide Domain; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphorylation; Phosphotransferases; Pilot Projects; Play; Potentiation; Production; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Domains; Protein Phosphorylation; Protein Synthesis, Ribosomal; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Pyramidal Cells; Receptor Protein; Receptors, AMPA; Regulation; Regulatory Protein; Relative; Relative (related person); Renpenning syndrome 2; Research; Role; SRC Substrate Cortactin; SRC8; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Somatosensory Cortex; Spectrin; Spinal Column; Spine; Structure; Synapses; Synaptic; Synaptic plasticity; Syndrome; Techniques; Tertiary Protein Structure; Testing; Therapeutic; Translations; Transphosphorylases; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vertebral column; Work; X-linked mental deficiency-megalotestes syndrome; X-linked mental retardation with fragile X syndrome; X-linked mental retardation-fragile site 1 syndrome; adult human (21+); autism spectrum disorder; autism-fragile X (AFRAX) syndrome; autism-fragile X syndrome; backbone; biological signal transduction; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cartilage link protein; cortactin; cross-link; crosslink; dendrite spine; disease/disorder; drug detection; drug testing; drug/agent; experiment; experimental research; experimental study; failure; fra(X) syndrome; fra(X)(28) syndrome; fra(X)(q27) syndrome; fra(X)(q27-28) syndrome; fragile X mental retardation 1; fragile X-mental retardation syndrome; fragile Xq syndrome; fragile site mental retardation 1; fragile x [{C0016667}]; fragile x syndromes; gene product; genetic regulatory protein; genome mutation; heavy metal Pb; heavy metal lead; hippocampal; homotypical cortex; human EMS1 protein; hydroxyaryl protein kinase; improved; in vivo; inhibitor; inhibitor/antagonist; intracellular skeleton; isocortex; link protein; macro-orchidism-marker X (MOMX) syndrome; macro-orchidism-marker X syndrome; mar(X) syndrome; marker X syndrome; mental retardation-macroorchidism syndrome; mouse model; mouse mutant; mutant; neopallium; novel; p80/85 SRC Substrate; pilot study; profilin; protein synthesis; public health relevance; pyridine; receptor; regulatory gene product; research study; restoration; social role; somatosensory; somesthetic sensory cortex; synapse function; synaptic function; tyrosyl protein kinase",Fragile X and Synaptic Plasticity," Efforts to identify causes of mental retardation associated with Fragile X Syndrome led to the discovery of synaptic plasticity impairments in a mouse model of the disorder. The present studies will test the hypothesis that impairments are due to abnormal levels of actin regulatory proteins, which are critical for changes in synaptic function during learning. Studies will also test potential therapeutics for correcting these synaptic defects that might improve learning in this syndrome and other autism spectrum disorders.",82042,DBD,Developmental Brain Disorders Study Section,,2,375119,
7758275,R01,MH,5,,02/01/2010,01/31/2011,PA-07-338,5R01MH082633-03,,NIMH:523016;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,STORRS-MANSFIELD,UNITED STATES,PSYCHOLOGY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"KALICHMAN, SETH C;",1895055;,5R01MH082633,02/15/2008,01/31/2013,"18 year old; AIDS; AIDS Drugs; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS/HIV; AIDS/HIV problem; AOD use; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adherence; Adherence (attribute); Alcohol or Other Drugs use; Anti-AIDS Agents; Anti-AIDS Drugs; Anti-HIV Agents; Anti-HIV Drugs; Anti-HIV Positivity; Anti-Human Immunodeficiency Virus Agents; Anti-Retroviral Agents; Antiretroviral Agents; Area; Attention; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Research; Behavioral Therapy; Behavioral Treatment; Caring; Clinic; Clinical; Communicable Diseases; Communities; Community Health Services; Comprehension; Conditioning Therapy; Counseling; Drugs; Education; Educational aspects; Elements; Gender; HIV; HIV Antibody Positivity; HIV Infections; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Health; Health Status; Health behavior change; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Informed Consent; Instruction; Intervention; Intervention Strategies; Investigation; Knowledge; LAV-HTLV-III; Lead; Level of Health; Life; Life Style Modification; Low Literacy Population; Lymphadenopathy-Associated Virus; Maintenance; Maintenances; Measures; Mediation; Medical; Medication; Mental Health; Mental Hygiene; Modeling; Motivation; NIH RFA; Negotiating; Negotiation; Outcome; Participant; Patient Self-Report; Patients; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Psychological Health; RGM; Randomized; Randomized Clinical Trials; Reading; Recruitment Activity; Regimen; Relative; Relative (related person); Request for Applications; Research; Research Resources; Resistance; Resources; Risk; Screening procedure; Self-Report; Services; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; Treatment outcome; Trials, Randomized Clinical; Viral; Viral Burden; Viral Load; Viral Load result; Virus-HIV; Woman; anti-retroviral; antiAIDS agent; antibody positive AIDS test; antigen positive AIDS test; antiretroviral; antiretroviral therapy; base; behavior change; behavior intervention; behavioral intervention; drug/agent; educationally disadvantaged; effective intervention; eighteen year old; experience; genetic variant; health literacy; heavy metal Pb; heavy metal lead; improved; intervention design; intervention development; intervention effect; interventional strategy; literacy; medication adherence; medication compliance; meetings; men; men's; metropolitan; patient population; post intervention; programs; randomisation; randomization; randomly assigned; recruit; resistant; screening; screenings; seropositive (AIDS test); skills; standard of care; substance use; success; theories; therapy design; therapy development; treatment adherence; treatment design; treatment development",HIV Treatment Adherence Intervention for People with Poor Literacy Skills,,82633,ZRG1,Special Emphasis Panel,,3,523016,
7778210,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH082783-02,,NIMH:275625;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,PSYCHIATRY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"GUR, RAQUEL E;",8502119;,5R01MH082783,03/01/2009,12/31/2011,"Academia; Address; Adverse effects; Agreement; Analysis, Data; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Anxiety; Applications Grants; Area; Arts; Behavior; California; Care Givers; Care giver Burden; Caregiver Burden; Caregivers; Characteristics; Charge; Clinical; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Cognition; Collaborations; Communities; Conduct Clinical Trials; Consensus; Consensus Development Conferences; Data; Data Analyses; Data Collection; Development; Disease; Disorder; Distress; Drug Industry; Drug Therapy; Drugs; Emotional; Ensure; Evaluation; FDA; Factor Analyses; Factor Analysis; Food and Drug Administration; Food and Drug Administration (U.S.); Gender; Generations; Government Agencies; Grant Proposals; Grants, Applications; Gur; Impairment; Industry; Industry, Pharmaceutic; Infrastructure; Interviewer; Investigators; Lead; Los Angeles; Major Tranquilizers; Manuals; Maryland; Measurement; Measures; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Moods; Motivation; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neurocognitive; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Occupational; Out-patients; Outcome; Outpatients; Participant; Patient Self-Report; Patients; Pb element; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmacotherapy; Phase; Play; Position; Positioning Attribute; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychology; Psychometric; Psychometrics; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Priority; Researchers; Role; Sampling; Schizoaffective Disorders; Schizophrenia; Schizophrenic Disorders; Self-Report; Severities; Sex Characteristics; Sex Differences; Site; Social Functioning; Sound; Sound - physical agent; Source; Structure; Symptoms; Techniques; Testing; Therapeutic Trials; Therapy Clinical Trials; Training; Tranquilizing Agents, Major; Treatment Side Effects; USFDA; United States Food and Drug Administration; United States National Institute of Mental Health; Universities; Validity and Reliability; Woman; Work; base; care giver stress; caregiver stress; clinical investigation; conference; dementia praecox; design; designing; disability; disease/disorder; drug/agent; emotional experience; functional outcomes; gender difference; heavy metal Pb; heavy metal lead; improved; instrument; intervention development; meetings; member; men; men's; method development; next generation; novel; programs; public health relevance; quality assurance; recruit; response; schizophrenic; sexual dimorphism (noncellular); side effect; social; social role; sound; success; symposium; theories; therapy adverse effect; therapy development; treatment adverse effect; treatment development",2/4-Collaboration to Advance Negative Symptom Assessment In Schizophrenia," Project Narrative Negative symptoms are major determinants of poor functional outcome in schizophrenia, and available treatments are largely ineffective for these symptoms. The proposed Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS) will carry out the main recommendation of the recent NIMH Consensus Development Conference to create and validate a new assessment instrument, the Negative Symptom Rating Scale, for use in clinical trials and other types of research. This state-of-the art instrument will play a central role in the NIMH initiative to stimulate the development of new treatments aimed at reducing the disability associated with negative symptoms.",82783,ZRG1,Special Emphasis Panel,,2,275625,
7760595,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH082784-03,,NIMH:337791;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ANN ARBOR,UNITED STATES,PHARMACOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"ELLINGROD, VICKI L;",2112832;,5R01MH082784,05/01/2008,01/31/2013,"2-amino-4-mercaptobutyric acid; 5,10-Methylenetetrahydrofolate Reductase (NADPH); 5-methyltetrahydrofolate[{..}]NADP oxidoreductase; Adverse effects; Alleles; Allelomorphs; Attenuated; Brachial Artery; Butanoic acid, 4,4'-dithiobis(2-amino)-; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Clinical Research; Clinical Study; Community Health; Data; Death, Sudden, Cardiac; Dehydrogenases; Development; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Dysfunction; EC 1.5.1.20; Environment; Epidemic; Face; Folate; Folate Metabolism; Folic Acid Metabolosm; Functional disorder; Funding; Future; General Population; General Public; Genetic; Genetics, Other; Genotype; Goals; Health Expenditures; History; Homocysteine; Homocysteine, L-Isomer; Homocystine; Incidence; Insulin Resistance; Intake; Intermediary Metabolism; Investigation; K-Awards; K-Series Research Career Programs; L-Methionine; Laboratories; Learning; Lifestyle Factors, Unspecified; Ligase; Link; METBL; MODY; MTHFR; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Medicine; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Metabolic; Metabolic Pathway; Metabolic Processes; Metabolic syndrome; Metabolism; Methionine; Methionine, L-Isomer; Methylene Tetrahydrofolate Reductase; Methylene-THF Reductase (NADPH); Methylenetetrahydrofolate Reductase; Methylenetetrahydrofolate Reductase (NADPH2); Methylenetetrahydrofolate reductase (NADPH); Morbidity; Morbidity - disease rate; NIDDM; NIH; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ System, Cardiovascular; Other Genetics; Oxidoreductase; Patients; Pharmacies; Pharmacogenetics; Pharmacogenomics; Pharmacy facility; Physicians; Physiopathology; Population; Proxy; Psychiatric Disease; Psychiatric Disorder; Psychological Health; QOL; Quality of life; Recording of previous events; Reductases; Research; Research Career Program; Research Career Programs, K-Series; Risk; Risk Factors; Role; Schizophrenia; Schizophrenic Disorders; Science of Medicine; Structure of brachial artery; Syndrome; Synthetases; T2D; T2DM; Therapeutic Uses; Treatment Side Effects; Type 2 diabetes; Type II diabetes; United States National Institute of Mental Health; United States National Institutes of Health; Unspecified Mental Disorder; Variant; Variation; Vascular Diseases; Vascular Disorder; Vascular, Heart; Weight Gain; Weight Increase; Work; adiposity; adult onset diabetes; attenuation; atypical antipsychotic; base; blood vessel disorder; body weight gain; body weight increase; brachial artery; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; circulatory system; clinical practice; college; corpulence; corpulency; corpulentia; dementia praecox; diabetes; experience; facial; folic acid metabolism; genetic variant; health care expenditure; health organization; innovate; innovation; innovative; insulin resistant; ketosis resistant diabetes; lifestyle factors; maturity onset diabetes; meetings; mental illness; obese; obese people; obese person; obese population; open label; pathophysiology; psychological disorder; public health relevance; schizophrenic; side effect; social role; therapy adverse effect; tool; treatment adverse effect; waist circumference; wt gain",Folate Pharmacogenomics and Risk of Atypical Antipsychtoic Metabolic Side Effects,,82784,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,3,337791,
7843471,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH082839-02,,NIMH:230648;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,COLLEGE PARK,UNITED STATES,PSYCHOLOGY,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"BLANCHARD, JACK J.;",1886186;,5R01MH082839,03/01/2009,12/31/2011,"Academia; Address; Adverse effects; Agreement; Analysis, Data; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Anxiety; Applications Grants; Area; Arts; Behavior; California; Care Givers; Care giver Burden; Caregiver Burden; Caregivers; Characteristics; Charge; Clinical; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Cognition; Collaborations; Communities; Conduct Clinical Trials; Consensus; Consensus Development Conferences; Data; Data Analyses; Data Collection; Development; Disease; Disorder; Distress; Drug Industry; Drug Therapy; Drugs; Emotional; Ensure; Evaluation; FDA; Factor Analyses; Factor Analysis; Food and Drug Administration; Food and Drug Administration (U.S.); Gender; Generations; Government Agencies; Grant Proposals; Grants, Applications; Gur; Impairment; Industry; Industry, Pharmaceutic; Infrastructure; Interviewer; Investigators; Lead; Los Angeles; Major Tranquilizers; Manuals; Maryland; Measurement; Measures; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Moods; Motivation; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neurocognitive; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Occupational; Out-patients; Outcome; Outpatients; Participant; Patient Self-Report; Patients; Pb element; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmacotherapy; Phase; Play; Position; Positioning Attribute; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychology; Psychometric; Psychometrics; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Priority; Researchers; Role; Sampling; Schizoaffective Disorders; Schizophrenia; Schizophrenic Disorders; Self-Report; Severities; Sex Characteristics; Sex Differences; Site; Social Functioning; Sound; Sound - physical agent; Source; Structure; Symptoms; Techniques; Testing; Therapeutic Trials; Therapy Clinical Trials; Training; Tranquilizing Agents, Major; Treatment Side Effects; USFDA; United States Food and Drug Administration; United States National Institute of Mental Health; Universities; Validity and Reliability; Woman; Work; base; care giver stress; caregiver stress; clinical investigation; conference; dementia praecox; design; designing; disability; disease/disorder; drug/agent; emotional experience; functional outcomes; gender difference; heavy metal Pb; heavy metal lead; improved; instrument; intervention development; meetings; member; men; men's; method development; next generation; novel; programs; public health relevance; quality assurance; recruit; response; schizophrenic; sexual dimorphism (noncellular); side effect; social; social role; sound; success; symposium; theories; therapy adverse effect; therapy development; treatment adverse effect; treatment development",1/4 Collaboration to Advance Negative Symptom Assessment in Schizophrenia," Project Narrative Negative symptoms are major determinants of poor functional outcome in schizophrenia and available treatments are largely ineffective for these symptoms. The proposed Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS) will carry out the main recommendation of the recent NIMH Consensus Development Conference to create and validate a new assessment instrument, the Negative Symptom Rating Scale, for use in clinical trials and other types of research. This state-of-the art instrument will play a central role in the NIMH initiative to stimulate the development of new treatments aimed at reducing the disability associated with negative symptoms.",82839,ZRG1,Special Emphasis Panel,,2,230648,
7778222,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH082890-02,,NIMH:245486;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BERKELEY,UNITED STATES,PSYCHOLOGY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"KRING, ANN M;",8874198;,5R01MH082890,03/01/2009,12/31/2011,"Academia; Address; Adverse effects; Agreement; Analysis, Data; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Anxiety; Applications Grants; Area; Arts; Behavior; California; Care Givers; Care giver Burden; Caregiver Burden; Caregivers; Characteristics; Charge; Clinical; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Cognition; Collaborations; Communities; Conduct Clinical Trials; Consensus; Consensus Development Conferences; Data; Data Analyses; Data Collection; Development; Disease; Disorder; Distress; Drug Industry; Drug Therapy; Drugs; Emotional; Ensure; Evaluation; FDA; Factor Analyses; Factor Analysis; Food and Drug Administration; Food and Drug Administration (U.S.); Gender; Generations; Government Agencies; Grant Proposals; Grants, Applications; Gur; Impairment; Industry; Industry, Pharmaceutic; Infrastructure; Interviewer; Investigators; Lead; Los Angeles; Major Tranquilizers; Manuals; Maryland; Measurement; Measures; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Moods; Motivation; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neurocognitive; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Occupational; Out-patients; Outcome; Outpatients; Participant; Patient Self-Report; Patients; Pb element; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmacotherapy; Phase; Play; Position; Positioning Attribute; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Psychology; Psychometric; Psychometrics; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Priority; Researchers; Role; Sampling; Schizoaffective Disorders; Schizophrenia; Schizophrenic Disorders; Self-Report; Severities; Sex Characteristics; Sex Differences; Site; Social Functioning; Sound; Sound - physical agent; Source; Structure; Symptoms; Techniques; Testing; Therapeutic Trials; Therapy Clinical Trials; Training; Tranquilizing Agents, Major; Treatment Side Effects; USFDA; United States Food and Drug Administration; United States National Institute of Mental Health; Universities; Validity and Reliability; Woman; Work; base; care giver stress; caregiver stress; clinical investigation; conference; dementia praecox; design; designing; disability; disease/disorder; drug/agent; emotional experience; functional outcomes; gender difference; heavy metal Pb; heavy metal lead; improved; instrument; intervention development; meetings; member; men; men's; method development; next generation; novel; programs; public health relevance; quality assurance; recruit; response; schizophrenic; sexual dimorphism (noncellular); side effect; social; social role; sound; success; symposium; theories; therapy adverse effect; therapy development; treatment adverse effect; treatment development",4/4 Collaboration to Advance Negative Symptom Assessment in Schizophrenia," Project Narrative Negative symptoms are major determinants of poor functional outcome in schizophrenia, and available treatments are largely ineffective for these symptoms. The proposed Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS) will carry out the main recommendation of the recent NIMH Consensus Development Conference to create and validate a new assessment instrument, the Negative Symptom Rating Scale, for use in clinical trials and other types of research. This state-of-the art instrument will play a central role in the NIMH initiative to stimulate the development of new treatments aimed at reducing the disability associated with negative symptoms.",82890,ZRG1,Special Emphasis Panel,,2,245486,
7766950,R01,MH,5,,01/01/2010,12/31/2010,PA-07-070,5R01MH083246-02,,NIMH:657855;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,PSYCHIATRY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"CASTELLANOS, FRANCISCO XAVIER;",6882159;,5R01MH083246,02/15/2009,12/31/2011,"21+ years old; AD/HD; ADHD; Accounting; Address; Adult; Affective Psychosis, Bipolar; Age; Anatomic; Anatomical Sciences; Anatomy; Anisotropy; Anterior; Antisocial Personality; Antisocial Personality Disorder; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Awareness; Awarenesses; Behavior; Behavioral; Bipolar Disorder; Brain; Brain imaging; Characteristics; Childhood; Clinical; Clinical Data; Comorbidity; Complex; Conduct Disorder; Corpus Striatum; Corpus striatum structure; DSM-IV; DSM4; Data; Dependence; Development; Diagnosis; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Dorsal; Drugs, Illicit; Dysfunction; Educational process of instructing; Encephalon; Encephalons; Event; Exhibits; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Hand; Handedness; History; Human, Adult; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Illicit Drugs; Impairment; Individual; Inferior Frontal Convolution; Inferior frontal gyrus; Investigators; Laterality; Learning Disorders; Link; Literature; MRI, Functional; Magnetic Resonance Imaging, Functional; Maps; Matched Group; Measures; Medial; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods; Middle Frontal Gyrus; Middle frontal gyrus structure; Modeling; Motor; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Parietal; Participant; Performance; Pervasive Development Disorder; Pervasive Developmental Disorder; Physiopathology; Prefrontal Cortex; Process; Psyche structure; Psychopathology; Psychoses; Psychosis, Manic-Depressive; Psychotic Disorders; Reaction Time; Recording of previous events; Relative; Relative (related person); Reporting; Reproduction; Research Personnel; Researchers; Response RT; Response Time; Rest; Sampling; Scanning; Science of Anatomy; Science of neurophysiology; Short-Term Memory; Socio-economic status; Socioeconomic Status; Sociopathic Personality; Specific qualifier value; Specified; Status, Socioeconomic; Striate Body; Striatum; Task Performances; Teaching; Time; Variant; Variation; abnormal psychology; adult human (21+); alertness; anatomy; attention deficit hyperactive disorder; base; bipolar affective disorder; blood oxygen level dependent; brain behavior; brain visualization; cingulate cortex; cognitive control; diffusion tensor imaging; disease/disorder; executive control; executive function; experiment; experimental research; experimental study; fMRI; healthy aging; improved; indexing; manic depressive disorder; manic depressive illness; meetings; mental; mental set; neural; neural circuit; neural circuitry; neuroimaging; neuronal; neurophysiology; neuropsychological; new approaches; novel; novel approaches; novel strategies; novel strategy; pathophysiology; pediatric; psychomotor reaction time; public health relevance; relating to nervous system; research study; response; sex; striatal; substantia alba; white matter; working memory",Functional and Structural Connectivity in Adult Attention Deficit Hyperactivity D," We propose to apply novel neuroimaging methods to better understand the brain mechanisms involved in Attention-Deficit/Hyperactivity Disorder (ADHD). Individuals with ADHD are highly inconsistent in their responses, and we will study a brain circuit that is associated with such inconsistency in 50 adults with ADHD and 50 healthy subjects. We will also measure key mental abilities that are suspected of being involved in ADHD, including alertness, working memory, ability to suppress unwanted responses, ability to shift mental set, and ability to time brief intervals. The proposed study has the potential to teach us about function and dysfunction of specific brain circuits in ADHD, a common and impairing condition. This information is needed to improve methods of diagnosis and to develop new treatments.",83246,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,2,657855,
7827967,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH083647-02,,NIMH:626266;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"SWARTZ, HOLLY A;",2093809;,5R01MH083647,05/08/2009,01/31/2014,"0-11 years old; Active Follow-up; Acute; Address; Affect; Age; Anxiety Disorders; Area; Child; Child Youth; Children (0-21); Communication; Conflict; Conflict (Psychology); Controlled Clinical Trials, Randomized; DSM-IV; DSM4; Data; Depressed mood; Depression; Depressive disorder; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Dysfunction; Emotional Depression; Exposure to; Family; Functional disorder; Generations; Human, Child; Lead; Link; Major Depressive Disorder; Maternal Exposure; Mediator; Mediator of Activation; Mediator of activation protein; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Mothers; Neurosis, Depressive; Outcome; Parenting; Parenting behavior; Parents; Pb element; Physiopathology; Population; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychotherapy; Public Health; Randomized; Randomized Controlled Clinical Trials; Recruitment Activity; Relative; Relative (related person); Risk; Risk Factors; Socio-economic status; Socioeconomic Status; Status, Socioeconomic; Symptoms; Symptoms of depression; Testing; Time; Translating; Translatings; Transmission; Trauma; Treatment outcome; Unspecified Mental Disorder; Youth; Youth 10-21; children; depressed; depressed mother; depressive; depressive symptoms; experience; follow-up; functional outcomes; heavy metal Pb; heavy metal lead; high risk; improved; intergenerational; language translation; major depression; maternal depression; meetings; mental illness; offspring; pathophysiology; psychological disorder; psychosocial; public health medicine (field); public health relevance; randomisation; randomization; randomized trial; randomly assigned; recruit; sadness; transmission process; treatment strategy; youngster",Interpersonal Psychotherapy for Depressed Mothers of Psychiatrically Ill Children," PROJECT NARRATIVE When psychiatrically ill children have mothers who suffer from depression, they do not recover from their own illnesses. Thus, the public health consequences of maternal depression are enormous not only for the mothers themselves, but also for their psychiatrically ill offspring. We will test a psychotherapy for maternal depression that directly targets factors that have been implicated in transmitting psychiatric illness risk to children-specifically, poor maternal functioning in interpersonal relationships and poor mother-child communication. We will compare the effects of this psychotherapy with a non-specific psychotherapy (supportive psychotherapy) on psychiatric outcomes in children and their mothers.",83647,ITMA,Interventions Committee for Adult Mood and Anxiety Disorders,,2,626266,
7789474,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH083710-02,,NIMH:386250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEWARK,UNITED STATES,NONE,10,130029205,US,NJ,07102,RUTGERS THE STATE UNIV OF NJ NEWARK,"PARE, DENIS ;",6690269;,5R01MH083710,03/19/2009,01/31/2014,"Adverse effects; Affect; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Anxiety Disorders; Area; Axon; Bed Nucleus of Stria Terminalis; Behavioral; Brain Stem; Brainstem; Cell Nucleus; Cells; Chemosensitization; Chemosensitization/Potentiation; Clinical; Common Rat Strains; Conditioned Stimulus; Connector Neuron; Dark Cell; Dependence; Extinction; Extinction (Psychology); Fear; Freezing; Fright; Glutamates; Human; Human, General; Hypothalamic structure; Hypothalamus; In Vitro; Intercalary Neuron; Intercalated Cell; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; L-Glutamate; Learning; Lesion; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Memory; Methods; Modeling; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleus; Pharmacological Treatment; Phase; Phobias; Phobic Disorders; Phobic Neuroses; Phobic anxiety disorder; Play; Population; Potentiation; Process; Rat; Rattus; Research; Role; Slice; Stimulus; Stria Terminalis Nucleus; Structure of terminal stria nuclei of preoptic region; Synapses; Synaptic; Testing; Training; Treatment Side Effects; amygdaloid nuclear complex; base; behavioral extinction; conditioned fear; design; designing; extracellular; fear conditioning; feeding; hypothalamic; improved; learning extinction; neurobiotin; neuronal; perceptual stimulus; physicochemical phenomena related to the senses; postsynaptic; presynaptic; prevent; preventing; public health relevance; response; sensory stimulus; side effect; social role; therapy adverse effect; treatment adverse effect; treatment strategy",Role of intercalated amygdala neurons in the extinction of conditioned fear,"  Although anxiety disorders affect close to 13% of the population, most available pharmacological treatments have a limited efficacy and entail important side effects. It is thus imperative that we improve our understanding of the mechanisms underlying anxiety disorders to design better treatment strategies. If supported, the hypothesis tested here would open new strategies for the treatment of anxiety disorders.",83710,ZRG1,Special Emphasis Panel,,2,386250,
7799956,R01,MH,5,,02/01/2010,01/31/2011,PA-07-085,5R01MH083712-02,,NIMH:413750;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"KLIN, AMI ;",6876377;,5R01MH083712,04/06/2009,01/31/2014,"0-11 years old; 2 year old; Acute; Address; Adolescent; Adolescent Youth; Adopted; Affect; Affective; Age; Area; Attention; Auditory; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Behavior; Biological; Bp50; Brain; Buccal Cavity; CD40; CDW40; Care Givers; Caregivers; Cartoons; Case Study; Cavitas Oris; Child; Child Development Disorders, Specific; Child Youth; Children (0-21); Cognitive; Collection; Complement; Complement Proteins; Cues; Development; Developmental Delay; Developmental Delay Disorders; Diagnosis; Diagnostic; Early Diagnosis; Early treatment; Encephalon; Encephalons; Environment; Event; Exhibits; Eye; Eyeball; Face; Fixation; Fixation, Ocular; Focusing, Ocular; Foundations; Future; Goals; Head and Neck, Buccal Cavity; Human; Human, Child; Human, General; Impairment; Individual; Infant; Kanner's Syndrome; Laboratories; Lead; Learning; Light; Lip; Lip structure; MGC9013; Man (Taxonomy); Man, Modern; Measures; Methods; Mind; Modality; Motion; Mouth; Movement; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nervous; Nervous System, Brain; Neurodevelopmental Disorder; Neurological Development Disorder; Ocular Fixation; Oral cavity; Outcome; Outcome Measure; Pattern; Pb element; Perception; Persons; Photoradiation; Physical Capacity; Predisposition; Process; Protocol; Protocols documentation; Public Health; Recruitment Activity; Relative; Relative (related person); Research; Role; Scanning; Screening procedure; Sensory; Series; Social Environment; Social Perception; Socialization; Socializations; Sound; Sound - physical agent; Speech; Speech Sound; Stimulus; Structure; Susceptibility; TNFRSF5; TNFRSF5 gene; Technology; Testing; Therapeutic; Time; Toddler; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; United States National Institutes of Health; Visual; Visual attention; Work; autism spectrum disorder; base; body movement; case report; children; cognitive function; cohort; disability; early detection; experience; experiment; experimental research; experimental study; facial; heavy metal Pb; heavy metal lead; indexing; insight; juvenile; juvenile human; neural; neuroimaging; p50; peer; public health medicine (field); public health relevance; recruit; relating to nervous system; research study; sample fixation; screening; screenings; skills; social; social climate; social context; social role; socioenvironment; sound; tool; two year old; visual fixation; youngster",Perception of Social and Physical Contingencies in Infants with ASD," 7. Project Narrative Relevance:  Our ability to diagnose and treat individuals with Autism Spectrum Disorders relies on the development of effective practical tools for quantifying and remedying the social and communicative disabilities that characterize this group. The research in this project will significantly further our understanding of the mechanisms underlying visual attention to social stimuli in infants with autism, and will show how quantification of visual scanning behavior in infants using eye-tracking technology may potentially provide tools for diagnosis and treatment. This research addresses several key action items of the NIH Interagency Autism Committee, emphasizing developmental markers and screening in infants, as well as neurodevelopmental processes, and is, therefore, highly relevant to public health.",83712,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,2,413750,
7789538,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH083807-02,,NIMH:269876;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAMPAIGN,UNITED STATES,PSYCHOLOGY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"RHODES, JUSTIN S;",6581975;,5R01MH083807,03/19/2009,01/31/2014,"5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Affect; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Arm; BUdR; Behavior; Biological; Blood capillaries; Brain; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CNS plasticity; Capillaries; Capillary; Capillary, Unspecified; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cognitive; Cognitive aging; Cornu Ammonis; Craniocerebral Trauma; Cues; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, Genetic; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dentate Fascia; Dentate Gyrus; Deposit; Deposition; Encephalon; Encephalons; Environment; Environmental Factor; Environmental Risk Factor; Exercise; Exercise, Physical; Fascia Dentata; Future; GFAC; Gamma Rays; Gene Organization; Gene Structure; Gene Structure/Organization; Genes; Genetic; Genetic Data Banks; Genetic Data Bases; Genetic Databanks; Genetic Databases; Genetic Information Databases; Genetic analyses; Genotype; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Gyrus Dentatus; Head Injuries; Head Trauma; Hippocampus; Hippocampus (Brain); Housing; Hydrogen Oxide; Individual; Injuries, Craniocerebral; Label; Laboratories; Learning; Mammals, Mice; Mammals, Rodents; Measures; Methods; Mice; Motor; Murine; Mus; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Growth; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neuronal Growth; Neuronal Plasticity; Neurons; Performance; Physiology; Procedures; Radial; Radiation, Gamma; Recovery; Reporting; Rodent; Rodentia; Rodentias; Rotation; Running; Sampling; Sensory; Specific qualifier value; Specified; Stroke; Structure of dentate gyrus; Testing; Transgenic Organisms; Upper arm; Uridine, 5-bromo-2'-deoxy-; Vascular Accident, Brain; Water; brain attack; capillary; cerebral vascular accident; clinical data repository; clinical data warehouse; conditioned fear; data repository; dentate gyrus; environmental risk; experience; experiment; experimental research; experimental study; fear conditioning; genetic analysis; hippocampal; innovate; innovation; innovative; interest; irradiation; model organism; morris water maze; morris watermaze; neural; neural plasticity; neurodegenerative illness; neurogenesis; neuronal; neuroplasticity; new growth; newborn neuron; phenome; physical conditioning; public health relevance; relating to nervous system; relational database; research study; response; sedentary; sex; stroke; transgenic",Mouse genetic differences in exercise-induced hippocampal neurogenesis & learning, Project Narrative The goal of this project is to discover mechanisms for pro-cognitive effects of exercise at multiple levels of biological organization from genes to physiology to behavior.,83807,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,2,269876,
7789636,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH083973-02,,NIMH:331500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PORTLAND,UNITED STATES,,01,050973098,US,OR,97232,EMANUEL HOSPITAL AND HEALTH CENTER,"BOISON, DETLEV ;",8464811;,5R01MH083973,03/20/2009,01/31/2014,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; ATP[{..}]adenosine 5'-phosphotransferase; Address; Adenosine; Adenosine A(2A) Receptor; Adenosine A2A Receptor; Adenosine Kinase; Adverse effects; Affect; Agonist; Ammon Horn; Animals; Assay; Behavioral; Behavioral Assay; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Brain; Brain region; Cell Communication and Signaling; Cell Signaling; Cognitive Manifestations; Cognitive Symptoms; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Development; Disease; Disorder; Dopamine; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Therapy; Drugs; Dysfunction; Encephalon; Encephalons; Engineering; Engineerings; Evaluation; Financial cost; Fore-Brain; Forebrain; Functional disorder; Future; Genetic; Glutamates; Hippocampus; Hippocampus (Brain); Human; Human, General; Hydroxytyramine; Individual; Infusion; Infusion procedures; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knockout Mice; L-Glutamate; Lead; Link; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Medication; Mental disorders; Mental health disorders; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modification; Molecular; Mother Cells; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nervous; Nervous System, Brain; Neurobehavioral Manifestations; Neurochemistry; Neuromodulator; Neuronal Transmission; Neurotransmitters; Null Mouse; Outcome; Outcome Study; P1 Purinoceptors; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Physiopathology; Play; Population; Position; Positioning Attribute; Progenitor Cells; Prosencephalon; Psychiatric Disease; Psychiatric Disorder; Public Health; Purinergic P1 Receptors; Receptor Protein; Receptors, Adenosine; Receptors, N-Methylaspartate; Receptors, Purinergic P1; Regulation; Relative; Relative (related person); Research; Role; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Signal Transduction; Signal Transduction Systems; Signaling; Signs and Symptoms, Neurobehavioral; Societies; Stem cells; Striate Body; Striatum; Study, Outcome; Symptoms; System; System, LOINC Axis 4; Testing; Therapeutic; Transgenic Mice; Transplantation; Treatment Side Effects; Unspecified Mental Disorder; Validation; Wild Type Mouse; base; behavior test; behavioral test; biological signal transduction; clinical efficacy; comparative; dementia praecox; disease/disorder; dopamine system; drug/agent; endophenotype; experiment; experimental research; experimental study; genetic manipulation; heavy metal Pb; heavy metal lead; hippocampal; improved; in vivo; interventional strategy; kinase inhibitor; mental illness; neural; neural control; neural regulation; neurochemistry; neuroregulation; neurotransmission; new approaches; novel; novel approaches; novel strategies; novel strategy; overexpression; pathophysiology; pathway; psychological disorder; psychopharmacologic; psychopharmacological; public health medicine (field); public health relevance; receptor; receptor function; relating to nervous system; research study; schizophrenic; side effect; social; social role; striatal; theories; therapy adverse effect; transplant; treatment adverse effect",Adenosine and schizophrenia: mechanisms and therapies," Project Narrative Relevance to public health Schizophrenia is a devastating mental disorder to the individual and society alike, yet the efficacy of current drug treatment remains poor, and the development of novel drugs is limited to either blocking dopamine or enhancing glutamate neurotransmission. This proposal will examine a novel drug target for schizophrenia-therapy -adenosine: Given adenosine'suniquepositiontointeractinparalelwithdopamineandglutamate neurotransmission, adenosine-modulating drugs are hypothesized to confer therapeutic potential against multiple SZ symptoms.",83973,ZRG1,Special Emphasis Panel,,2,331500,
7795043,R01,MH,5,,02/01/2010,01/31/2011,PAR-07-249,5R01MH084795-02,,NIMH:336355;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SALT LAKE CITY,UNITED STATES,PSYCHIATRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"LAINHART, JANET ELIZABETH;",6230265;,5R01MH084795,04/01/2009,01/31/2014,"0-11 years old; 20 year old; 21+ years old; Acute; Address; Adolescent; Adolescent Youth; Adult; Advanced Development; Age; Alcohols; Algorithms; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Architecture; Area; Arts; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Automobile Driving; Back; Base of the Brain; Behavior; Behavioral; Benchmarking; Best Practice Analysis; Biological; Biological Neural Networks; Biology; Biomedical Computing; Biopsy, Needle; Brain; Brain imaging; CNS lupus; California; Canada; Cancer Intervention; Cancer of Prostate; Cancer, Oncology; Care, Health; Causality; Cells; Central Nervous System Lupus; Characteristics; Chemical Class, Alcohol; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical; Clinical Evaluation; Clinical Research; Clinical Study; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Collaborations; Communities; Community Practice; Comorbidity; Complex; Computational algorithm; Computer Programs; Computer Software Development; Computer Software Engineering; Computer software; Computers; Computing Methodologies; Control Groups; Data; Data Banks; Data Bases; Data Set; Data Sources; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Designing computer software; Development; Diagnosis; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Dorsum; Drivings, Automobile; EEG; Early treatment; Education; Educational aspects; Electroencephalography; Elements; Encephalon; Encephalons; Engineering; Engineering / Architecture; Engineering, Software; Engineerings; Ensure; Environment; Epilepsy; Epileptic Seizures; Epileptics; Equation; Equipment and supply inventories; Etiology; Evaluation; Event; Evolution; Forecast of outcome; Fostering; Functional Magnetic Resonance Imaging; Funding; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Models; Genetic Variation; Genital System, Male, Prostate; Genomics; Goals; HOSP; Head circumference; Healthcare; Heterogeneity; Hospitals; Human Prostate; Human Prostate Gland; Human, Adult; Human, Child; Image; Image Analyses; Image Analysis; Imagery; Impairment; Individual; Infrastructure; Institutes; Interdisciplinary Research; Interdisciplinary Study; Internet; Intervention; Intervention Strategies; Inventory; Investigators; Iowa; Journals; Kanner's Syndrome; Knowledge; Language; Length; Lesion; Licensing; Life; Link; Liver neoplasms; Local Therapy; Localized Therapy; Location; Lupus; MR Imaging; MR Tomography; MRI; MRI, Functional; MS (Multiple Sclerosis); Macaca mulatta; Magazine; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Measurement; Measures; Medical; Medical Imaging; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Medical Research; Medicine; Mentally Disabled; Mentally Disabled Persons; Mentally Handicapped; Mentally Retarded; Metabolic; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Microscopic; Mind; Mission; Modality; Modeling; Models, Genetic; Modification; Monitor; Multidisciplinary Collaboration; Multidisciplinary Research; Multimodal Imaging; Multimodality; Multiple Sclerosis; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Needle biopsy procedure; Neoplasms, Hepatic; Nervous; Nervous System, Brain; Neural Development; Neuropsychiatric Systemic Lupus Erythematosus; North Carolina; Nuclear Magnetic Resonance Imaging; Ontario; Organ; Outcome; PET; PET Scan; PET imaging; PETSCAN; PETT; Participant; Pathogenesis; Patients; Pattern; Persons; Phenotype; Philosophy; Population; Positron Emission Tomography Scan; Positron-Emission Tomography; Preventive Intervention; Primary Senile Degenerative Dementia; Procedures; Process; Production; Prognosis; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Proton Magnetic Resonance Spectroscopic Imaging; Public Health; Publications; RF ablation; ROC Analysis; Rad.-PET; Radio Frequency Ablation; Radiofrequency Ablation; Radiofrequency Interstitial Ablation; Receptor Protein; Research; Research Infrastructure; Research Personnel; Research Resources; Research, Medical; Researchers; Resolution; Resources; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk; Robotics; Schizophrenia; Schizophrenic Disorders; Science of Medicine; Scientific Publication; Scientist; Sclerosis, Disseminated; Sedlackova syndrome; Segmentation, imaging; Seizure Disorder; Self Administration; Services; Severities; Shapes; Shprintzen syndrome; Software; Software Design; Software Engineering; Software Validation; Software Verification; Solutions; Sources, Data; Statistical Methods; Stereotyping; Stress; Structure; Study, Interdisciplinary; Syndrome; System; System, LOINC Axis 4; Systemic Lupus Erythematosis, Central Nervous System; Techniques; Technology; Testing; Thick; Thickness; Time; Training; United States National Institutes of Health; Universities; Utah; Validation; Variant; Variation; Variation (Genetics); Visualization; WWW; Weight; Woman; Work; Zeugmatography; adult human (21+); age dependent; age related; allelic variant; autism spectrum disorder; base; biomedical computation; brain tissue; brain visualization; children; clinical data repository; clinical data warehouse; clinical investigation; clinical phenotype; clinical test; cohort; computational methodology; computational methods; computational tools; computer methods; computer program/software; computerized tools; conference; data repository; dementia of the Alzheimer type; dementia praecox; design; designing; diffusion tensor imaging; direct application; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; driving; empowered; epilepsia; epileptiform; epileptogenic; experience; fMRI; file format; forest; gray matter; hepatic neoplasia; hepatic neoplasm; image evaluation; imaging; imaging Segmentation; imaging modality; improved; innovate; innovation; innovative; insular sclerosis; interest; interoperability; interventional strategy; juvenile; juvenile human; liver tumor; male; meetings; member; morphometry; neural; neural circuit; neural circuitry; neural network; neurobiological mechanism; neurodevelopment; neuroimaging; neuropathology; neuropsychological; novel; oncology; open source; outcome forecast; pediatric; prenatal; preventional intervention strategy; primary degenerative dementia; public health medicine (field); quality assurance; receptor; relating to nervous system; relational database; research clinical testing; schizophrenic; senile dementia of the Alzheimer type; shape analysis; shape description; social; substantia alba; substantia grisea; success; symposium; technology development; time use; tool; tool development; twenty year old; unborn; velo-cardio-facial syndrome; velocardiofacial syndrome; velocardiofacial syndrome (VCF, VCFS); velofacial hypoplasia; web; white matter; wiki; world wide web; youngster",The Microstructural Basis of Abnormal Connectivity in Autism,,84795,ZRG1,Special Emphasis Panel,,2,336355,
7799858,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH085320-02,,NIMH:371250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN ANTONIO,UNITED STATES,OTHER BASIC SCIENCES,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"BOYER, THOMAS G;",7038135;,5R01MH085320,04/07/2009,01/31/2014,"Affect; Area; Autoregulation; Behavioral; Biochemical; Biological Function; Biological Process; Causality; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Central Nervous System; Cognitive; DNA Alteration; DNA mutation; DNA-Dependent RNA Polymerase II; Defect; Development; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Etiology; FG Syndrome; G9a histone methyltransferase; Gene Action Regulation; Gene Alteration; Gene Down-Regulation; Gene Expression; Gene Expression Regulation; Gene Inactivation; Gene Mutation; Gene Regulation; Gene Regulation Process; Gene Silencing; Gene Targeting; Gene Transcription; Gene variant; Genes; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Transcription; Genetic Variation; Genetic defect; Genetic mutation; Glia; Glial Cells; Goals; Health; Homeostasis; Human; Human, General; Intracellular Communication and Signaling; Investigators; Keller syndrome; Kolliker's reticulum; Link; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Mental Retardation, X-Linked; Missense Mutation; Molecular; Mutation; Mutation, Missense; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System Diseases; Nervous System, CNS; Nervous system structure; Neural Cell; Neural Stem Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neuronal Differentiation; Neurons; Non-neuronal cell; Opitz-Kaveggia syndrome; Organism-Level Process; Organismal Process; Pathologic; Physiologic Processes; Physiological Homeostasis; Physiological Processes; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; RE1-silencing transcription factor; RNA Expression; RNA Polymerase B; RNA Polymerase II; Regulation; Replacement Therapy; Repression; Repressor Proteins; Research Personnel; Researchers; Role; SCHED; Schedule; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Syndrome; Targetings, Gene; Therapeutic; Transcription; Transcription Repression; Transcription, Genetic; Transcriptional Repression; Variation (Genetics); X-Linked Mental Retardation; X-Linked Mental Retardation Disorders; X-Linked Mental Retardation Syndromes; Xq13; allelic variant; base; biological signal transduction; cell fate specification; cell growth; cognitive function; disease causation; disease etiology; disease/disorder etiology; disorder etiology; gene repression; genome mutation; insight; nerve cement; nerve stem cell; nervous system disorder; neural progenitor cells; neurological disease; neuron development; neuronal; neuronal progenitor; neuronal progenitor cells; neuropsychiatric; neuropsychiatry; programs; prospective; public health relevance; social role; stem cell biology; stem cell differentiation; transcription factor",Mediator and epigenetic control of neuronal gene expression and differentiation," PROJECT NARRATIVE We expect these studies to have important implications for cell replacement therapy in neurological disease as well as the etiology of developmental and cognitive defects in humans. First, studies proposed herein to elucidate the mechanism (Aim 1) and regulation (Aim 2) of MED12/Mediator in control of neuronal gene expression and differentiation are expected to break new ground and illuminate fundamental aspects of neural stem cell biology that will be essential to guide prospective cell-based therapeutic approaches to repopulate damaged or diseased areas of the nervous system. Second, studies proposed herein to evaluate the impact of XLMR-associated mutations in MED12 on its basic biochemical properties and functional interactions relevant to neuronal gene repression and neural stem cell differentiation (Aim 3) should reveal new mechanistic insight concerning the etiology of XLMR and possibly identify new avenues for therapeutic or remedial intercession.",85320,ZRG1,Special Emphasis Panel,,2,371250,
7782792,R01,MH,5,,02/01/2010,01/31/2011,PA-07-089,5R01MH085597-02,,NIMH:342751;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAPEL HILL,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MARGOLIS, DAVID M.;",1959449;,5R01MH085597,04/01/2009,01/31/2014,"AIDS; AIDS Dementia; AIDS Dementia Complex; AIDS Virus; AIDS with dementia; AIDS-related dementia; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immune Deficiency Syndrome related dementia; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Affinity; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Anti-Retroviral Agents; Antiretroviral Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Antiviral Drugs; Antivirals; Arm; Au element; Autopsy; Behavioral; Biological Models; Blood - brain barrier anatomy; Blood-Brain Barrier; Body Tissues; Caliber; Cell Culture Techniques; Cell Nucleus; Cells; Central Nervous System; Characteristics; Chemicals; Chemistry; Clinical; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Consensus; Consequences of HIV; Cytoplasm; D-Glucose; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Dextrose; Diameter; Discipline; Disease; Disorder; Disturbance in cognition; Drug Formulations; Drug or chemical Tissue Distribution; Drug resistance; Drugs; Encephalitis; Figs; Figs - dietary; Flexibility; Formulation; Formulations, Drug; Frequencies (time pattern); Frequency; Glucose; Goals; Gold; Guidelines; HAART; HIV; HIV Dementia; HIV Infections; HIV associated dementia; HIV therapy; HIV-1; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-I; HIV-related dementia; HIV/AIDS; HIV/AIDS problem; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hemato-Encephalic Barrier; Highly Active Antiretroviral Therapy; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Hybrids; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Impaired cognition; Incidence; Individual; Infection; Inflammation, Brain; Integrase Inhibitors; LAV-HTLV-III; Ligands; Lymphadenopathy-Associated Virus; Mammals, Mice; Medical; Medication; Medicine; Metric; Mice; Minor; Model System; Modeling; Models, Biologic; Molecular and Cellular Biology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motor; Murine; Mus; NRVS-SYS; Nervous System; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, CNS; Nervous system structure; Neuraxis; Neurocognitive; Neurologic Body System; Neurologic Manifestations; Neurologic Organ System; Neurologic Signs and Symptoms; Neurological Damage; Neurological Injury; Neurological Manifestations; Neurological trauma; Nucleus; Patients; Penetration; Pharmaceutic Preparations; Pharmaceutical Preparations; Pliability; Prevalence; Property; Property, LOINC Axis 2; Proteins; Recording of previous events; Research; Salts; Science of Anatomy; Science of Chemistry; Science of Medicine; Science of Virology; Surface; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Testing; Therapeutic; Tissue Distribution; Tissues; Toxic effect; Toxicities; Trauma, Nervous System; Upper arm; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virology; Virus-HIV; anatomy; anti-retroviral; anti-retroviral therapy, highly active; antiretroviral; antiretroviral therapy; base; cognitive dysfunction; cognitive loss; cognitively impaired; density; design; designing; disease/disorder; drug resistant; drug/agent; gene product; human T cell leukemia virus III; human T lymphotropic virus III; improved; in vivo; in vivo Model; meetings; model organism; motor disease; motor disorder; nano crystal; nano meter scale; nano meter sized; nano scale; nano therapeutic; nanocrystal; nanometer scale; nanometer sized; nanoscale; nanotherapeutic; necropsy; neural manifestation; new therapeutics; next generation therapeutics; novel; novel therapeutics; particle; postmortem; protein protein interaction; public health relevance; resistance to Drug; resistant to Drug; scaffold; scaffolding; small molecule; virology; virus protein",Nanocrystal delivery to the CNS to improve HIV therapy," Highly active antiretroviral therapy (ART) has led to a significant decrease in the morbidity and mortality of HIV- infected individuals, but poor penetration of ART into the CNS allows continued HIV replication in the CNS. Our approach to target the CNS aims to take advantage of the chemical pliability of gold nanocrystals, allowing them to be armed with chemical moieties that confer antiviral properties and allow the crystals to access the CNS. We will test novel nanotherapeutics in cell culture and animal model systems of the blood-brain barrier and of HIV infection.",85597,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,2,342751,
7812225,R01,MH,5,,02/01/2010,01/31/2011,PA-07-070,5R01MH085602-02,,NIMH:356250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PHILADELPHIA,UNITED STATES,NEUROSCIENCES,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"LANGFORD, TERESA DIANNE;",7817018;,5R01MH085602,05/01/2009,01/31/2014,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acquired brain injury; Address; Adhesion Plaques; Amentia; Amino Acid Sequence; Binding; Binding (Molecular Function); Biological; Brain; Brain Injuries; CNS Diseases; CNS disorder; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cell-Matrix Adherens Junctions; Cells; Central Nervous System Diseases; Central Nervous System Disorders; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Communication; Cysteine; Data; Dementia; Disease; Disease Progression; Disorder; Disturbance in cognition; Drugs; ECM; Encephalon; Encephalons; Export, Nuclear; Exposure to; Extracellular Matrix; Extracellular Matrix, Integrins; Focal Adhesions; Focal Contacts; GFAC; Glia; Glial Cells; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HIV; HIV Infections; HRG; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Half-Cystine; Hand; Hives; Host Factor; Host Factor Protein; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; ILK; Impaired cognition; Impairment; In Vitro; Individual; Infection; Inflammatory; Injury; Integration Host Factors; Integrins; Intracellular Communication and Signaling; Isoforms; Kolliker's reticulum; L-Cysteine; LAV-HTLV-III; Life; Lymphadenopathy-Associated Virus; MALD-MS; MALDI; MALDI-MS; Mediating; Medication; Molecular Biology, Protein Sequencing; Molecular Interaction; Mutagenesis, Site-Directed; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurites; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurological; Neurons; Non-neuronal cell; Nuclear; Nuclear Export; Pathway interactions; Patients; Pattern; Peptide Sequence Determination; Peptide Signal Sequences; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Sequencing; Protein Structure, Primary; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; QOL; Quality of life; RNA, Small Interfering; Recovery; Recruitment Activity; Reporting; Research; Role; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Severities; Signal Pathway; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Small Interfering RNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Synapses; Synaptic; T-Lymphotropic Virus Type III Infections, Human; Targeted DNA Modification; Targeted Modification; Testing; Time; Urticaria; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus-HIV; adapter protein; biological signal transduction; brain cell; brain damage; brain lesion (from injury); cognitive dysfunction; cognitive loss; cognitively impaired; disease/disorder; drug/agent; fitness; gene product; histatins; histidine-rich proteins; improved; integrin-linked kinase; interest; laser capture microdissection; matrix assisted laser desorption ionization; nerve cement; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal survival; p59(ILK); pathway; protein complex; protein expression; protein function; protein sequence; protein signal sequence; public health relevance; recruit; release factor; repair; repaired; response; siRNA; social role; trafficking; virus protein",Role of PINCH in neuronal response to HIV infection of the CNS," RELEVANCE HIV patients are much living longer due to effective anti-HIV medications. Anti-HIV medications are less effective at treating HIV in the brain. So, many HIV patients suffer from neurological impairments. In this context, PINCH protein may contribute to neuron recovery during HIV infection of the brain. Understanding mechanisms by which PINCH functions will contribute to improved therapies to protect the brain from damage by HIV, and may improve the quality of life in HIV patients.",85602,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,2,356250,
7758853,R01,NR,5,,02/01/2010,01/31/2011,PAS-03-168,5R01NR010004-05,,NINR:406122;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,INDIANAPOLIS,UNITED STATES,PEDIATRICS,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"ZIMET, GREGORY D.;",1964124;,5R01NR010004,04/01/2006,01/31/2011,"AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS test; AIDS/HIV; AIDS/HIV problem; AIDS/HIV test; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Advocate; African American; Afro American; Afroamerican; Analysis, Data; Anti-HIV Positivity; Arm; Attitude; Behavior; Behavioral; Belief; Black Populations; Black or African American; Clinic; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Community Health; Computer Assisted; Data Analyses; Development; Drug usage; Education Level; Educational Background; Enrollment; Equation; Equilibrium; Ethnic Origin; Ethnicity; Ethnicity aspects; Female Groups; Focus Groups; Group Interviews; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV test; HIV vaccine; HIV/AIDS; HIV/AIDS Vaccines; HIV/AIDS problem; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Individual; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Intervention Studies; Interview; Interviews, Group; Investigators; LAV-HTLV-III; Latina; Lead; Link; Literature; Logistic Regressions; Lymphadenopathy-Associated Virus; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Minority; Modeling; Non-Hispanic; Not Hispanic or Latino; Outcome; Participant; Pb element; Perception; Persuasion; Persuasive Communication; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Planning Theory; Preventive; Process; Programs (PT); Programs [Publication Type]; Public Health; Race; Racial Group; Randomized; Recording of previous events; Recruitment Activity; Regressions, Logistic; Research; Research Personnel; Researchers; Services; Side; Source; Stocks, Racial; Structure; Survey Instrument; Surveys; Testing; Theory, Planning; Upper arm; Vaccination; Vaccine Clinical Trial; Vaccines; Virus-HIV; Woman; Women's Group; antibody positive AIDS test; antigen positive AIDS test; balance; balance function; black American; clinical investigation; computer aided; design; designing; drug use; enroll; group intervention; health belief; health-related belief; heavy metal Pb; heavy metal lead; human immunodeficiency virus vaccine; improved; interventional strategy; phase 3 study; phase 3 trial; phase III trial; programs; protocol, phase III; public health medicine (field); randomisation; randomization; randomly assigned; recruit; response; seropositive (AIDS test); study, phase III; theories; treatment trial; willingness",HIV Testing and Women's Attitudes on HIV Vaccine Trials,,10004,BSCH,Behavioral and Social Consequences of HIV/AIDS Study Section,,5,406122,
7761729,R01,NR,5,,02/01/2010,01/31/2011,PA-07-070,5R01NR010015-03,,NINR:403684;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,KINGSTON,UNITED STATES,NONE,02,796475382,US,RI,028810811,UNIVERSITY OF RHODE ISLAND,"MERCER, JUDITH SMITH;",8580205;,5R01NR010015,02/01/2008,01/31/2013,"Accident and Emergency department; Acquired brain injury; Active Follow-up; Address; Adopted; Affect; Analysis, Data; Animal Welfare; Behavioral; Bibliography; Birth; Blinded; Blood Volume; Body Tissues; Brain Injuries; Budgets; Cerebral Palsy; Child Development Disorders, Specific; Clinical; Cognitive; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Computers; Confounding Factor, Epidemiologic; Confounding Factors (Epidemiology); Confounding Variables; Country; Critiques; Data; Data Analyses; Development; Developmental Delay; Developmental Delay Disorders; Discipline; Ecological impact; Editorial Comment; Editorial Comment (PT); Embryonic Tissue, Placenta; Emergency Department; Emergency room; Enrollment; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Future; Generalized Growth; Gestation; Goals; Grouping; Growth; HOSP; Hospitalization; Human Resources; Hypovolemia; IACUC; IRBs; Impact, Environmental; Infant; Infant, Premature; Infant, Very Low Birth Weight; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Ischemia; Knowledge; Left; Light; Manpower; Manuals; Measures; Medical center; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mothers; Neonatal; Neural Development; Nurseries; Nurses; Operation; Operative Procedures; Operative Surgical Procedures; Organizations, Professional; Outcome; Parturition; Perfusion; Personnel, Nursing; Phase; Photoradiation; Physiologic; Physiological; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Policies; Population; Posters; Posters [Publication Type]; Pregnancy; Premature Infant; Principal Investigator; Professional Organizations; Programs (PT); Programs [Publication Type]; Published Comment; Randomized; Randomized Controlled Trials; Regression Analyses; Regression Analysis; Regression Diagnostics; Reporting; Research; Research Ethics Committees; Research Resources; Resources; SCHED; Sampling; Schedule; Schools; Sepsis; Statistical Regression; Surgical; Surgical Interventions; Surgical Procedure; Time; Tissue Growth; Tissues; Umbilical Cord; Umbilical cord structure; United States; Vertebrate Animals; Vertebrates; Very Low Birth Weight Infant; Viewpoint; Viewpoint (PT); Visit; abstracting; bloodstream infection; brain damage; brain lesion (from injury); cytokine; design; designing; enroll; expiration; fetal; follow up assessment; follow-up; groupings; high risk infant; human subject; innovate; innovation; innovative; interest; interventional strategy; intraventricular hemorrhage; male; meetings; neurodevelopment; ontogeny; personnel; posters; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; programs; protective effect; randomisation; randomization; randomized controlled study; randomized trial; randomly assigned; secondary outcome; surgery; tertiary care; vertebrata; very low birth weight infant human",PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTS,,10015,NSCF,Nursing Science:  Children and Families Study Section,,3,403684,
7763217,R01,NR,5,,02/01/2010,01/31/2011,,5R01NR010127-03,,NINR:350762;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,UNIVERSITY PARK,UNITED STATES,OTHER HEALTH PROFESSIONS,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"PENROD, JANICE L;",2889476;,5R01NR010127,02/01/2008,01/31/2012,"21+ years old; ALS; Address; Adult; Amyotrophic Lateral Sclerosis; Belief; Cancer of Lung; Care Givers; Care giver Burden; Caregiver Burden; Caregivers; Caring; Cell Communication and Signaling; Cell Signaling; Cessation of life; Clinic Visits; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cognitive; Complex; Death; Disease; Disorder; Distress; Effectiveness; End of Life Care; Ethnography; Family; Family Care Giver; Family Caregiver; Fostering; Gehrig's Disease; Goals; Hand; Health Care Providers; Health Personnel; Health Status; Healthcare Providers; Healthcare worker; Heart failure; Human, Adult; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Knowledge; Level of Health; Life; Longitudinal Studies; Lou Gehrig Disease; Love; Malignant Tumor of the Lung; Malignant neoplasm of lung; Mental Health; Mental Hygiene; Modeling; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Nature; Out-patients; Outcome; Outpatients; PROV; Pattern; Persons; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Provider; Psychological Health; Pulmonary Cancer; Pulmonary malignant Neoplasm; QOL; Quality of life; Reading; Research; Research Personnel; Researchers; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Supportive Therapy; Supportive care; System; System, LOINC Axis 4; Time; Translating; Translatings; Uncertainty; Visits, Clinic; Work; adult human (21+); base; biological signal transduction; cardiac failure; care delivery; care giver stress; care giving; care systems; caregiver stress; caregiving; clinical investigation; delivery of care; disease/disorder; doubt; efficacy testing; end of life; ethnographic; ethnographic method; experience; health care personnel; health care worker; health provider; healthcare personnel; improved; innovate; innovation; innovative; interventional strategy; language translation; long-term study; lung cancer; medical personnel; programs; prospective; psychologic; psychological; response; social role; systems of care; theories; treatment provider",Exploring the Formal/Informal Caregiver Interface across 3 Death Trajectories,,10127,NSAA,Nursing Science:  Adults and Older Adults Study Section,,3,350762,
7759504,R01,NR,5,,02/01/2010,01/31/2011,,5R01NR010939-03,,NINR:510768;,2010,NATIONAL INSTITUTE OF NURSING RESEARCH,,ANN ARBOR,UNITED STATES,NONE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"CIMPRICH, BERNADINE E.;",1891205;,5R01NR010939,02/15/2008,01/31/2012,"Acute; Address; Adjuvant Chemotherapy; Adjuvant Therapy; Adverse effects; Age; Attention; Biological; Brain; Brain imaging; Brain region; Breast Cancer Treatment; Cancer Survivor; Cancer of Breast; Cerebrum; Chemotherapy, Adjuvant; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Decision Making; Development; Distress; Disturbance in cognition; Drug Therapy, Adjuvant; Education; Educational aspects; Effects, Longterm; Encephalon; Encephalons; Event; Fatigue; Foundations; Functional Magnetic Resonance Imaging; Image Analyses; Image Analysis; Imaging technology; Impaired cognition; Impairment; Incidence; Intervention; Intervention Strategies; Investigators; Knowledge; Lack of Energy; Lead; Learning; Life; Link; Long-Term Effects; Longitudinal Studies; MRI, Functional; Magnetic Resonance Imaging, Functional; Malignant Tumor of the Breast; Malignant neoplasm of breast; Measurement; Measures; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Nervous; Nervous System, Brain; Neurophysiology - biologic function; Neuropsychologic Tests; Neuropsychological Tests; Newly Diagnosed; Patient Self-Report; Patients; Pattern; Pb element; Performance; Principal Investigator; Problem Solving; Process; Programs (PT); Programs [Publication Type]; QOL; Quality of life; ROC Analysis; Recovery; Reporting; Research; Research Personnel; Research Priority; Researchers; Role; Self-Report; Severities; Short-Term Memory; Source; Staging; Symptoms; System; System, LOINC Axis 4; Technology; Testing; Time; Treatment Side Effects; Woman; Work; base; brain visualization; chemobrain; chemotherapy; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; daily functioning; design; designing; fMRI; heavy metal Pb; heavy metal lead; image evaluation; improved; interventional strategy; long-term study; malignant breast neoplasm; neural; neural function; physical state; programs; psychologic; psychological; relating to nervous system; side effect; social role; therapy adverse effect; treatment adverse effect; working memory",Altered Brain Function in Chemotherapy for Breast Cancer,,10939,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,3,510768,
7751893,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS007080-43,,NINDS:387161;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"MCEWEN, BRUCE S.;",1891302;,5R01NS007080,09/01/1974,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Actins; Address; Adult; Affect; Agonist; Ammon Horn; Apoplexy; Aquadiol; Behavior; Behavioral; Brain; Brain region; CREB; CREB1; CREB1 gene; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Matrix; Cerebral Stroke; Cerebral cortex; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Change of Life, Female; Chemotherapy-Hormones/Steroids; Cognitive; Common Rat Strains; Confocal Microscopy; Cornu Ammonis; Corpus Luteum Hormone; Cytoskeletal System; Cytoskeleton; Data; Delta4-pregnene-3,20-dione; Dendrites; Dimenformon; Diogyn; Diogynets; Down-Regulation; Down-Regulation (Physiology); Downregulation; Electron Microscopy; Encephalon; Encephalons; Endocrine Gland Secretion; Environment; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogenic Agents; Estrogenic Compounds; Estrogens; Event; Excision; Extirpation; Female; Foundations; Gene Expression; Gene Transcription; Genetic Transcription; Genomics; Golgi; Golgi Apparatus; Golgi Complex; Gonadal Hormones; HMG-20; High Mobility Protein 20; Hippocampus; Hippocampus (Brain); Hormones; Human; Human, Adult; Human, General; Hypothalamic structure; Hypothalamus; In Vitro; Intracellular Communication and Signaling; Investigators; Isoforms; LIM Domain Kinase 1; LIM kinase; LIMK protein; LIMK-1; LIMK1; Laboratories; Laboratory Study; Learning; Life; Light; Location; Macaca mulatta; Macropain; Macroxyproteinase; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Memory; Menopause; Mice; Mice, Transgenic; Microscopy, Confocal; Modification; Molecular; Monkeys; Morphology; Multicatalytic Proteinase; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NRVS-SYS; Nerve Cells; Nerve Tissue; Nerve Unit; Nervous System; Nervous System, Brain; Nervous Tissue; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Nuclear; Operation; Operative Procedures; Operative Surgical Procedures; Ovarian; Ovarian Cycles; Ovarian hormone; Ovocyclin; Ovocylin; Pathway interactions; Peptide Biosynthesis, Ribosomal; Phosphorylation; Photoradiation; Physiologic; Physiological; Prefrontal Cortex; Pregn-4-ene-3,20-dione; Pregnenedione; Process; Progesterone; Progesterone Receptors; Programs (PT); Programs [Publication Type]; Progynon; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Isoforms; Protein Phosphorylation; Protein Synthesis, Ribosomal; Proteosome; RNA Expression; Rat; Rattus; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Progesterone; Receptors, Progestin; Regulation; Removal; Reporting; Reproduction; Research; Research Personnel; Researchers; Rest; Rhesus; Rhesus Macaque; Rhesus Monkey; Rodent; Rodentia; Rodentias; Role; SNK gene product, enzyme; Seizures; Serine/Threonine-Protein Kinase SNK; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spinal Column; Spine; Staining method; Stainings; Stains; Steroid Compound; Steroids; Stroke; Structure; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Synapses; Synaptic; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Transcription; Transcription, Genetic; Transgenic Mice; Ubiquitin; Vascular Accident, Brain; Vertebral column; Wild Type Mouse; adult human (21+); age dependent; age related; backbone; base; biological signal transduction; brain attack; brain cell; cerebral vascular accident; cofilin; cognitive function; deprivation; experiment; experimental research; experimental study; genetic manipulation; hippocampal; hypothalamic; immunocytochemistry; in vivo; intracellular skeleton; menopausal; multicatalytic endopeptidase complex; neuronal; non-genomic; nongenomic; ovulation time; pathway; polymerization; progesterone receptor; programs; protein expression; protein synthesis; receptor; research study; resection; response; serum-inducible kinase; social role; stroke; surgery; synapse formation; synaptogenesis",Gene Expression in Nervous Tissue,,7080,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,43,387161,
7761701,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS015547-29,,NINDS:339324;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PATHOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GERSHON, MICHAEL D;",1866726;,5R01NS015547,12/01/1979,01/31/2011,"5HT transporter; 5HTT protein; Adhesion Molecule; Affect; Afferent Neurons; Aganglionic Megacolon; Age; Alternate Splicing; Alternative Splicing; American; Anatomic Abnormality; Anatomical Abnormality; Animals; Antibodies; Axon; BHLH Protein; Basic HLH Protein; Basic Helix-Loop-Helix Protein; Basic Helix-Loop-Helix Transcription Factors; Behavior; Binding; Binding (Molecular Function); Biochemical; Birth Defects; Brain; Brain Stem; Brainstem; CRC18; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Signaling; Cells; Cellular Migration; Childhood; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Code; Coding System; Colitis, Mucous; Colon; Colon, Irritable; Colorectal Cancer-Related Chromosome Sequence 18; Commit; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Anomalies, Nervous System; Congenital Defects; Congenital Deformity; Congenital Malformation; Congenital Megacolon; Congenital neurologic anomalies; Congenital or Acquired Anatomic Abnormality; Congenital or Acquired Anatomical Abnormality; Constipation; DCC gene; DMN; Data; Defect; Deformity; Deleted in Colorectal Carcinoma; Development; Digestive Diseases; Digestive System Diseases; Digestive System Disorders; Disease; Disorder; Dorsal; Dorsal Motor Nucleus of the Vagus; Dorsal Root Ganglia; Drosophila sli protein; Dyspepsia; Encephalon; Encephalons; Enteral; Enteric; Enteric Nervous System; Esophageal Reflux; Event; F and A; FLR; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Failure (biologic function); Fiber; GERD; GP80-LNGFR; Ganglia; Ganglia, Spinal; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gastro-oesophageal Reflux; Gastroesophageal Reflux; Gastroesophageal reflux disease; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, in situ Hybridization; Glia; Glial Cells; Goals; Growth; HOSP; Heterogeneity; Hirschsprung Disease; Hospitalization; Human; Human, General; INFLM; In Situ Hybridization; In Vitro; Indigestion; Indigestions; Indirect Costs; Infection; Inflammation; Inflammatory; Injury; Intestinal; Intestines; Intracellular Communication and Signaling; Irritable Bowel Syndrome; Isoforms; Knock-out; Knockout; Kolliker's reticulum; L-tryptophan,tetrahydropteridine[{..}]oxygen oxidoreductase (5-hydroxylating); Label; Lead; Life; Maintenance; Maintenances; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Motility; Motility, Cellular; Motor; Murine; Mus; Mutation; Myxoid cyst; NGF Receptor; NGFR; NGFR Protein; Nerve; Nerve Cells; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity; Nerve Unit; Nervous; Nervous System Abnormalities; Nervous System Anomalies; Nervous System Congenital Abnormalities; Nervous System Congenital Malformations; Nervous System Malformations; Nervous System Physiology; Nervous System, Brain; Neural Cell; Neural Crest; Neural Ganglion; Neural Growth; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurologic function; Neurological; Neurological function; Neuronal Growth; Neurons; Neurons, Afferent; Neurons, Sensory; Neurotropin Receptor p75; Nodose Ganglion; Non-neuronal cell; Nucleus; Office Visits; Oils; Pathogenesis; Pathology; Patients; Pb element; Pelvic; Pelvic Region; Pelvis; Peripheral; Peripheral Nerves; Physicians; Play; Pluripotent Stem Cells; Population; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; Proteins; RNA Splicing; RNA Splicing, Alternative; RNA, Small Interfering; Receptor Protein; Receptor, Nerve Growth Factor; Regulation; Reporting; Rodent; Rodentia; Rodentias; Role; Sacral nerve; Sensory; Sensory Cell Afferent Neuron; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Source; Spinal Ganglia; Splicing; Structure; Synapses; Synaptic; Testing; Time; Tissue Growth; To specify; Transcript; Transgenic Mice; Tryptophan 5-monooxygenase; Tryptophan Hydroxylase; Tryptophan Monooxygenase; ULCN; Ulcer; Ulceration; Variant; Variation; Visit; afferent nerve; base; biological signal transduction; bowel; cell adhesion protein; cell motility; congenital nervous system disorder; cost; dSlit protein, Drosophila; deleted in colorectal cancer; digestive disorder; disease/disorder; dorsal motor nucleus; dorsal root ganglion; dysmotility; dysmotility syndrome; failure; gene product; genome mutation; gliogenesis; gp75 NGFR; heavy metal Pb; heavy metal lead; immunocytochemistry; in situ Hybridization Staining Method; in vivo; injury response; innervation; insight; laminin-1; loss of function; motility disorder; nerve cement; nerve supply; nervous system development; nervous system function; neural; neurogenesis; neuron development; neuronal; ontogeny; p75 neurotrophin receptor; p75(NTR); p75NTR; pediatric; pelvirectal achalasia; physician office visit; postsynaptic; precursor cell; presynaptic; prevent; preventing; receptor; recombinase; relating to nervous system; response to injury; sensory nerve; serotonin transporter; siRNA; sli protein, Drosophila; slit protein; social role; sodium-dependent serotonin transporter; spastic colon; synapse formation; synaptogenesis; tryptophan 5 hydroxylase; wdh protein, Drosophila",Microenvironment in Enteric Neuron Development,,15547,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,29,339324,
7754671,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS016996-31,,NINDS:335673;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STONY BROOK,UNITED STATES,NEUROSCIENCES,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"MENDELL, LORNE M.;",8277520;,5R01NS016996,09/01/1980,01/31/2012,"21+ years old; Accounting; Active Follow-up; Acute; Adult; Adverse effects; Age; Axon; Axotomy; Brain; Bruise; CNS plasticity; Cells; Chemosensitization; Chemosensitization/Potentiation; Chronic; Common Rat Strains; Contusions; DNA Sequence Rearrangement; Data; Dependence; Development; Effects, Longterm; Encephalon; Encephalons; Exhibits; Exposure to; Glutamate Receptor; Goals; HDNF; Hand; Human, Adult; In Vitro; Injury; Intramuscular; Investigators; Kainic Acid Receptors; Laboratories; Lead; Long-Term Effects; Mammals, Rats; Mediating; Medulla Spinalis; Methods; Modeling; Motor Cell; Motor Neurons; Myelopathy, Traumatic; N-Methyl-D-Aspartate Receptors; NGF-2; NMDA Receptor-Ionophore Complex; NMDA Receptors; NT3; NTF3; NTF3 gene; Natural regeneration; Neonatal; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neuronal Plasticity; Neurons; Nociceptors; Pain; Painful; Pb element; Peptide Biosynthesis, Ribosomal; Peripheral; Peripheral Nerves; Physiologic; Physiological; Potentiation; Preparation; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Rat; Rattus; Rearrangement; Receptor Protein; Receptors, Kainate; Receptors, Kainic Acid; Receptors, N-Methylaspartate; Recovery; Recovery of Function; Regeneration; Research Personnel; Researchers; Role; Signal Pathway; Spinal; Spinal Cord; Spinal Cord Plasticity; Spinal Cord Trauma; Spinal Injuries; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Time; Transmission; Treatment Side Effects; Work; adult human (21+); clinical significance; clinically significant; critical period; decline in function; experimental analysis; follow-up; functional decline; functional recovery; heavy metal Pb; heavy metal lead; improved; in vivo; interest; kainate; motoneuron; neonate; neural plasticity; neuronal; neuroplasticity; neurotrophic factor; neurotrophin; neutrophin; postnatal; prevent; preventing; programs; protein synthesis; receptor; regenerate; response; side effect; social role; spine injury; therapy adverse effect; transmission process; treatment adverse effect; vertebral injury",Mechanisms of Plasticity in Neuronal Connections,,16996,SMI,Sensorimotor Integration Study Section,,31,335673,
7760104,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS018218-27,,NINDS:334026;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STONY BROOK,UNITED STATES,NEUROSCIENCES,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"HALEGOUA, SIMON ;",1863677;,5R01NS018218,04/01/1982,01/31/2011,"API3; Accounting; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Axon; Axonal Transport; Axoplasmic Transport; BIRC4; BIRC4 gene; Binding; Binding (Molecular Function); Biochemistry; Cell Body; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Chaperone; Chemistry, Biological; Clathrin; Communication; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Disputes; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Down Syndrome; Down's Syndrome; Downs Syndrome; Dysfunction; EGF; EGF gene; EGFR; ERBB Protein; ERBB1; Electron Microscopy; Endosomes; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Functional disorder; Funding; Generalized Growth; Genes; Goals; Grant; Growth; HER1; Half-Life; Half-Lifes; Heart; ILP; Image; Individual; Intracellular Communication and Signaling; Investigators; Langdon Down syndrome; Life; MIHA; MVB; Mediating; Membrane Protein Traffic; Membrane Traffic; Messenger RNA; Molecular; Molecular Chaperones; Molecular Interaction; Mongolism; Multivesicular Body; Nerve; Nerve Cells; Nerve Endings; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neuronal Differentiation; Neurons; PTK Receptors; Pathway interactions; Phenotype; Physiopathology; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Protein Binding; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; RTK; Reagent; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Receptosomes; Relative; Relative (related person); Research Personnel; Researchers; Resolution; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Starvation; System; System, LOINC Axis 4; Testing; Therapeutic; Tissue Growth; Transforming Growth Factor alpha Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Trisomy 21; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; URG; XIAP; base; biological signal transduction; c-erbB-1; c-erbB-1 Protein; cell body (neuron); chromosome 21 trisomy syndrome; combat; computerized data processing; congenital acromicria syndrome; d-Numb; data processing; dementia of the Alzheimer type; design; designing; disease/disorder; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; gene product; imaging; in vivo; mRNA; morbus Down; neural cell body; neuron cell death; neuron loss; neuronal; neuronal cell body; neuronal cell death; neuronal loss; neuronal survival; neurotrophic factor; neurotrophin; neutrophin; novel; numb protein; ontogeny; pathophysiology; pathway; prevent; preventing; primary degenerative dementia; programs; proto-oncogene protein c-erbB-1; pseudohypertrophic progressive muscular dystrophy; receptor; research study; restoration; retrograde transport; senile dementia of the Alzheimer type; signal processing; social role; soma; success; trisomy 21 syndrome",Molecular Mechanisms of Neuronal Differentiation,,18218,NDGB,Neural Degenerative Disorders and Glial Biology Study Section,,27,334026,
7760596,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS018338-26,,NINDS:327010;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MINNEAPOLIS,UNITED STATES,NEUROSCIENCES,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"EBNER, TIMOTHY J;",1869049;,5R01NS018338,04/01/1982,01/31/2013,"Address; Affect; Animal Welfare; Animals; Applications Grants; Arm; Articulation; Behavioral; Bibliography; Cell Communication and Signaling; Cell Count; Cell Nucleus; Cell Number; Cell Signaling; Cells; Central Nervous System; Cerebellar Cortex; Cerebellar Nuclei; Cerebellar cortex structure; Cerebellum; Country; Coupled; Critiques; Cues; Data; Dependence; Development; Dissociation; Ecological impact; Ensure; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Extremities; Eye Movements; FLR; Failure (biologic function); Feedback; Figs; Figs - dietary; Future; Goals; Grant Proposals; Grants, Applications; Hand; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Isometric Exercise; Isometrics; Joints; LBUL; Laboratories; Lateral; Limb structure; Limbs; Lobule; Manuals; Mechanics; Membrum superius; Methods; Modeling; Monitor; Monkeys; Motor; Movement; Muscle; Muscle Tissue; Muscle-Setting Exercise; Nature; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Non-Trunk; Nuclear; Nucleus; Output; Performance; Population; Position; Positioning Attribute; Principal Investigator; Probability; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Publishing; Relative; Relative (related person); Reports, Progress; Research; Research Ethics Committees; Research Resources; Resources; Sensory; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Site; Speed; Speed (motion); Staging; Static Exercise; System; System, LOINC Axis 4; TXT; Testing; Text; Time; Torque; Training; Transducers; Upper Extremity; Upper Limb; Upper arm; Vertebrate Animals; Vertebrates; abstracting; base; biological signal transduction; body movement; expiration; failure; feeding; haptics; human subject; improved; kinematics; limb movement; motor control; neuronal; programs; psycho-physiological; response; vertebrata; visual feedback; visual motor; visuomotor",Cerebellum and Visually Guided Arm Movements,,18338,SMI,Sensorimotor Integration Study Section,,26,327010,
7760113,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS019895-27,,NINDS:324845;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"BYRNE, JOHN H;",1891342;,5R01NS019895,04/01/1983,01/31/2013,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; ATF2; ATF2 gene; Address; Affect; Afferent Neurons; After Care; After-Treatment; Aftercare; Animal Welfare; Antibodies; Antibodies, Blocking; Aplysia; Assay; Behavior; Behavioral; Bibliography; Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Blocking Antibodies; Blotting, Western; Budgets; C10; CNS plasticity; CRE-BP1; CREB; CREB1; CREB1 gene; CREB2; Cell Culture Techniques; Cell Nucleus; Cells; Cellular Morphology; Complement; Complement Proteins; Complex; Coon's Technic; Coon's Technique; Country; Critiques; Data; Defect; Ecological impact; Effectiveness; Effects, Longterm; Enteramine; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Figs; Figs - dietary; Fluorescent Antibody Technic; Fluorescent Antibody Technique; Fluorescent Antinuclear Antibody Test; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Transcription; Goals; HB16; Half-Life; Half-Lifes; Hippophaine; Human; Human, General; IACUC; IRBs; Immunofluorescence Technic; Immunofluorescence Technique; Impact, Environmental; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Lead; Learning; Long-Term Effects; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measures; Mediating; Memory; Memory Disorders; Messenger RNA; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Molecular; Monitor; Motor Cell; Motor Neurons; Myxoid cyst; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Ganglion; Neural Transmission; Neurocyte; Neuronal Plasticity; Neurons; Neurons, Afferent; Neurons, Sensory; Nuclear; Nucleus; Pattern; Pb element; Phase; Phosphorylation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Public Health; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Small Interfering; RNAi; Recombinants; Regulation; Reporter; Research; Research Ethics Committees; Research Resources; Resources; Retention Disorders, Cognitive; Role; Sensory Cell Afferent Neuron; Sequence-Specific Posttranscriptional Gene Silencing; Serotonin; Small Interfering RNA; Synapses; Synapsins; Synaptic; Synaptic Transmission; Synaptic Vesicles; TREB7; Techniques; Testing; Time; Training; Transcription; Transcription, Genetic; Vertebrate Animals; Vertebrates; Western Blotting; Western Blottings; Western Immunoblotting; Work; abstracting; base; cell morphology; design; designing; experiment; experimental research; experimental study; expiration; fluorescent antibody; gene product; heavy metal Pb; heavy metal lead; human subject; improved; long term memory; mRNA; motoneuron; neural; neural control; neural mechanism; neural plasticity; neural regulation; neuromechanism; neuronal; neuroplasticity; neuroregulation; presynaptic; programs; protein blotting; protein expression; public health medicine (field); relating to nervous system; research study; siRNA; social role; synapse formation; synapse function; synaptic function; synaptogenesis; tool; transcription factor; vector; vertebrata",Analysis of the Neural Control of Behavior,,19895,LAM,Neurobiology of Learning and Memory Study Section,,27,324845,
7755900,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS020212-25,,NINDS:377470;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MCCARTHY, KEN DOUGLAS;",1880197;,5R01NS020212,12/01/1983,12/31/2013,"3'5'-cyclic ester of AMP; Adenosine; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Area; Astrocytes; Astrocytus; Astroglia; Attention; Behavior; Behavioral; Biological Models; Blood Coagulation Factor IV; Blood Vessels; Brain; Ca++ element; Calcium; Cell Communication and Signaling; Cell Signaling; Cells; Coagulation Factor IV; Communication; Cyclic AMP; Elements; Encephalon; Encephalons; Exhibits; Factor IV; G Protein-Complex Receptor; G alpha q Protein; G-Protein, Gq; G-Protein, Gq alpha Family; G-Protein-Coupled Receptors; GTP Binding Protein alpha Subunit, Gq; Galphaq Protein; Genetic; Glutamate Receptor; Glutamates; Goals; Gq Protein; INFLM; In Situ; Inflammation; Intracellular Communication and Signaling; Investigation; L-Glutamate; Laboratories; Lead; Ligands; Link; Literature; Mammals, Mice; Mediating; Membrane; Metabotropic Glutamate Receptors; Mice; Mice, Transgenic; Model System; Models, Biologic; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; P1 Purinoceptors; Pb element; Physiologic; Physiological; Play; Process; Publications; Purinergic P1 Receptors; Pyramidal neuron; Receptor Protein; Receptors, Adenosine; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Regulation; Reporting; Role; Science of neurophysiology; Scientific Publication; Series; Signal Transduction; Signal Transduction Systems; Signaling; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Transgenic Mice; adenosine 3'5' monophosphate; biological signal transduction; brain cell; cAMP; caged IP3; chronic pain; chronic painful condition; controlled release; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hippocampal pyramidal neuron; in vivo; knockout gene; membrane structure; nervous system disorder; neurological disease; neuronal; neuropathology; neurophysiology; postsynaptic; presynaptic; public health relevance; receptor; receptor-mediated signaling; research study; social role; vascular",Neuronal-Astrocytic Communication In Vivo,,20212,ZRG1,Special Emphasis Panel,,25,377470,
7761265,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS020561-25,,NINDS:310694;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PULLMAN,UNITED STATES,VETERINARY SCIENCES,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"RITTER, ROBERT C;",1905440;,5R01NS020561,04/01/1984,02/28/2013,"Adipocytes; Adipose Cell; Amino Acids; Antidiabetic Hormone; Artifacts; Barium-Swallow X-ray; Blood Coagulation Factor IV; Blood Plasma; Body Weight; C-terminal; CCK; CCK-58; Ca++ element; Calcium; Cell Body; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapy-Hormones/Steroids; Cholecystokinin; Coagulation Factor IV; Colon; Common Rat Strains; Disease; Disorder; Distal; Dose; Duodenum; Eating; Endocrine; Endocrine Gland Secretion; Factor IV; Fat Cells; Fiber; Food Intake; GCG; GLP-1; GLP-1 receptor; GLP-I receptor; Gastrointestinal Hormones; Gastrointestinal Tract, Small Intestine; Glucagon; Glucagon (1-29); Glukagon; Goals; HG-Factor; Health; Hormones; Hyperglycemic-Glycogenolytic Factor; Image; In Vitro; Infusion; Infusion procedures; Intestinal; Intestines; Intestines, Small; Intracellular Communication and Signaling; Investigation; Ions; L Cells (Cell Line); L cell; Label; Laboratories; Leptin; Lipocytes; Mammals, Rats; Mature Lipocyte; Mature fat cell; Messenger RNA; Morphologic artifacts; Mucosa; Mucosal Tissue; Mucous Membrane; Nerve Cells; Nerve Fibers; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurotoxins; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Operation; Operative Procedures; Operative Surgical Procedures; Pancreozymin; Pathology; Peptides; Peripheral; Physiologic; Physiological; Physiology; Plasma; Process; Progress Reports; Property; Property, LOINC Axis 2; RNA, Messenger; Rat; Rattus; Relative; Relative (related person); Reporting; Reports, Progress; Research; Reticuloendothelial System, Serum, Plasma; Role; Satiation; Satiations; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Small Intestines; Stomach; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Therapeutic Hormone; UPGISER; Upper GI; Upper Gastrointestinal Series; Upper Gastrointestinal Tract Radiography; Uropancreozymin; Visceral Afferents; Weight Gain; Weight Increase; Weight maintenance regimen; Width; Work; aminoacid; biological signal transduction; body weight gain; body weight increase; bowel; cell body (neuron); cholecystokinin 58; cholecystokinin 8; disease/disorder; experiment; experimental research; experimental study; feeding; gastric; gastrointestinal; glucagon-like peptide 1; glucagon-like peptide-1 receptor; ileum; imaging; in vivo; innervation; jejunum; mRNA; nerve supply; neural; neural cell body; neural mechanism; neuromechanism; neuronal; neuronal cell body; neurotoxicant; ob/ob mouse; peptide hormone; premature; proglucagon (72-108); proglucagon (78-107); proglucagon (78-107)amide; public health relevance; ratiometric; relating to nervous system; research study; response; sample collection; satiety; small bowel; social role; soma; specimen collection; surgery; upper GI series; weight control; wt gain",Neural Substrates of Peptide Induced Satiety," PROJECT NARRATIVE This research is intended to characterize the interaction of gastrointestinal hormones with other signals, such as leptin, and to determine the extent to which visceral afferents participate in the cooperative control of food intake and body weight by gastrointestinal hormones and leptin.",20561,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,25,310694,
7765620,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS024014-22,,NINDS:330908;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ROCKVILLE,UNITED STATES,,08,144676566,US,MD,20852,HENRY M. JACKSON FDN FOR THE ADV MIL/MED,"JULIANO, SHARON L;",1909131;,5R01NS024014,07/01/1986,01/31/2011,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Address; Affect; Alcohol, Methyl; Alcohols; Animals; Antimitotic Agents; Antimitotic Drugs; Antimitotics; Axon; Birth; Calcium-Binding Proteins; Carbinol; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Characteristics; Chemical Class, Alcohol; Chromosomal, Gene, or Protein Abnormality; Cocaine; Collection; Complex; Cortical Dysplasia; Cortical Malformation; Cues; Cytogenetic or Molecular Genetic Abnormality; Development; Dysplasia; Embryo; Embryonic; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equilibrium; FLR; Failure (biologic function); Ferrets; Genetic; Genetic Abnormality; Gestation; Human; Human, General; Immigrations; In Vitro; In-Migration; Interruption; Intracellular Communication and Signaling; Lead; Man (Taxonomy); Man, Modern; Maps; Mediating; Methanol; Microtubular Function Inhibitors; Mitosis Inhibitor Agents; Mitosis Inhibitor Drugs; Mitosis Inhibitors; Mitotic Inhibitor Agents; Mitotic Inhibitor Drugs; Mitotic Inhibitors; Modeling; Molecular Abnormality; Mother Cells; Motility; Motility, Cellular; Neocortex; Neonatal; Nerve Cells; Nerve Unit; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neuronal Growth; Neurons; Parturition; Pb element; Population; Position; Positioning Attribute; Pregnancy; Process; Progenitor Cells; Property; Property, LOINC Axis 2; Radiation; Receptor Protein; Route; Schizophrenia; Schizophrenic Disorders; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Somatosensory Cortex; Stem cells; Symptoms; Syndrome; Testing; Thalamic structure; Thalamus; Toxin; Transplantation; Ventricular; Wood Alcohol; alcohol exposed; alcohol exposure; balance; balance function; biological signal transduction; cell motility; cohort; dementia praecox; dyscrasia; ethanol exposed; ethanol exposure; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; failure; heavy metal Pb; heavy metal lead; homotypical cortex; in vivo; information processing; isocortex; lissencephaly; migration; neocortical; neopallium; nerve stem cell; neural progenitor cells; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; novel; perceptual stimulus; physicochemical phenomena related to the senses; pregnant; ray (radiation); receptor; repair; repaired; research study; schizophrenic; sensory stimulus; somesthetic sensory cortex; thalamic; transplant",Structural correlates of cortical information processing,,24014,ZRG1,Special Emphasis Panel,,22,330908,
7755038,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS025304-21,,NINDS:317451;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AURORA,UNITED STATES,BIOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"MACKLIN, WENDY B;",1891129;,5R01NS025304,07/01/1987,12/31/2013,"21+ years old; AMPA Receptors; Adult; Animals; Brain; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Surface Proteins; Cell-Extracellular Matrix; Cells; Cellular Migration; Central Nervous System; Cerebellum; Complex; Cranial Nerve II; Data; Demyelinating Diseases; Demyelinating Disorders; Development; Down-Regulation; Down-Regulation (Physiology); Downregulation; EC 2.7.2-; ECM; EGFP protein; Embryo; Embryonic; Encephalon; Encephalons; Environment; Event; Extracellular Matrix; Extracellular Matrix, Integrins; Extracellular Signal-Regulated Kinases; Figs; Figs - dietary; Folch-Lees Protein; Folch-PI Proteolipid Protein; Funding; Gene Expression; Goals; Grant; Human, Adult; Image; Immigrations; In Vitro; In-Migration; Integrins; Intracellular Communication and Signaling; Knockout Mice; Learning; Lymphocytes, Null; MAP kinase; MAPK; MS (Multiple Sclerosis); Mediating; Membrane; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinases; Mother Cells; Motility; Motility, Cellular; Multiple Sclerosis; Myelin; Myelin PLP; Myelin Proteins; Myelin Proteolipid Protein; NRVS-SYS; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Null Cells; Null Lymphocytes; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Optic Nerve; PLP; Pathway interactions; Progenitor Cells; Protein Binding; Proteins; Proteins, Cell Surface; Proteolipids; Publishing; Receptor Activation; Receptors, AMPA; Receptors, Neurohumor; Regulation; Relative; Relative (related person); Role; Scaffolding Protein; Sclerosis, Disseminated; Second Cranial Nerve; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Stem cells; Surface; Telencephalon; Testing; Time; Transgenes; adult human (21+); biological signal transduction; cell motility; cell type; dysmyelinating; dysmyelination; enhanced green fluorescent protein; gene product; human disease; imaging; in vivo; insight; insular sclerosis; membrane structure; migration; mutant; myelin proteolipid; neuron development; neuronal; novel; null mutation; pathway; postnatal; progenitor; protein complex; protein expression; proteolipid protein of myelin; public health relevance; receptor function; response; social role",Myelin protein gene expression in dysmyelinating mutants," The myelin proteolipid protein (PLP) makes up 50% of the protein in the myelin membrane in the central nervous system. However, it is also expressed in embryos, neurons and other nonmyelinating cells. The current studies investigate the hypothesis that in addition to its apparent structural role in myelin, this protein is also involved in cell signaling, which influences how the oligodendrocyte progenitors and immature neurons migrate in the developing nervous system. We have published studies that demonstrate that PLP interacts with integrins, which are cell surface proteins that influence cell-cell and cell- substrate contact. PLP also interacts with neurotransmitter receptors on the surface of oligodendrocyte progenitor cells, which respond to neurotransmitters. The presence of neurotransmitters in the developing nervous system may influence both oligodendrocytes and neurons as they develop, and the fact the PLP and integrins and neurotransmitter receptors interact and change the way the oligodendrocyte progenitor cells migrate is important for normal brain development. In order to investigate our hypothesis, we will pursue the following studies. We will identify other proteins that are involved in this complex and investigate the signaling pathways that these proteins use to modulate oligodendrocyte progenitor cell and immature neuron migration. We will delete PLP, integrin or the neurotransmitter receptor from oligodendrocytes, and investigate how this impacts oligodendrocyte progenitor migration in culture. We will then study animals that have had these proteins selectively deleted, to learn how oligodendrocyte progenitor cells or immature neurons migrate in the developing nervous system, in embryos, in the developing cerebellum and in the developing optic nerve. These studies will have impact for a number of developmental human diseases and will provide insight into how to induce remyelination in adults, in demyelinating diseases such as multiple sclerosis.",25304,CMBG,Cellular and Molecular Biology of Glia Study Section,,21,317451,
7753192,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS027881-16,,NINDS:342170;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,VALHALLA,UNITED STATES,PHYSIOLOGY,18,041907486,US,NY,10595,NEW YORK MEDICAL COLLEGE,"LEONARD, CHRISTOPHER S;",1908232;,5R01NS027881,12/01/1991,01/31/2012,"Apnea, Sleep; Attenuated; Behavior; Biochemistry; Blood Coagulation Factor IV; Body Tissues; Brain; Ca++ element; Calcium; Cataplexy; Cell Communication and Signaling; Cell Signaling; Cells; Chemistry, Biological; Chronic; Coagulation Factor IV; Coupled; Depression; Doctor of Philosophy; Encephalon; Encephalons; Enzymes; Excessive Daytime Sleepiness; Excessive daytime somnolence; Factor IV; Funding; Gelineau Syndrome; Goals; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Henneberg Syndrome; Idiopathic Parkinson Disease; Insomnia; Insomnia Disorder; Intracellular Communication and Signaling; Investigators; Ion Channel; Ionic Channels; Lewy Body Parkinson Disease; Mammals, Mice; Measures; Membrane Channels; Mental Depression; Messenger RNA; Mice; Molecular; Murine; Mus; Narcolepsy; Narcoleptic Syndrome; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Palsy; Paradoxical Sleep; Paralysed; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Paroxysmal Sleep; Pathology; Peptides; Ph.D.; PhD; Phenotype; Plegia; Primary Parkinsonism; Programs (PT); Programs [Publication Type]; Proteins; REM Sleep; RNA, Messenger; Receptor Protein; Regulation; Research Personnel; Researchers; Rhombencephalic Sleep; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Sleep Hypopnea; Sleep, Fast-Wave; Sleep, REM; Sleep-Disordered Breathing; Sleeplessness; Slice; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Tissues; Tonelessness Syndrome; Transmission; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); Wakefulness; Wakefulnesses; base; behavioral pharmacology; biological signal transduction; cholinergic; cholinergic neuron; dreaming sleep; experiment; experimental research; experimental study; extracellular; gene product; hypocretin; hypocretin/orexin; hypocretins/orexins; imaging modality; mRNA; neural; neural mechanism; neuromechanism; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; novel; orexin; paralysis; paralytic; patch clamp; programs; rapid eye movement sleep; receptor; relating to nervous system; research study; sleep control; sleep problem; sleep regulation; transmission process; voltage",Synaptic modulation of mesopontine cholinergic neurons,,27881,ZRG1,Special Emphasis Panel,,16,342170,
7761312,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS028695-20,,NINDS:352654;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"FORSCHER, PAUL ;",1899915;,5R01NS028695,08/01/1990,01/31/2013,"Actin Filaments; Actins; Acute; Address; Adhesion Molecule; Algorithms; Animal Welfare; Assay; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Cell Adhesion Molecules; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Matrix; Cellular Migration; Characteristics; Complex; Country; Cues; Cytoskeletal Proteins; Cytoskeletal System; Cytoskeleton; Development; Distal; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Feeds; Filopodia; Generations; Growth Cones; Head; IACUC; IRBs; Image; Imagery; Imaging technology; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Life; Math Models; Methods and Techniques; Methods, Other; Micro-tubule; Microfilaments; Microscopy; Microtubule Proteins; Microtubules; Molecular; Molecular Interaction; Motility; Motility, Cellular; Movement; Myofilaments; Myosin II; Myosin Type II; Names; Nerve Cells; Nerve Unit; Neural Cell; Neurites; Neurocyte; Neurons; Play; Polymers; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Analysis; Protein Dynamics; Proteins; Recycling; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Role; Signal Transduction Pathway; Structure; Techniques; Vertebrate Animals; Vertebrates; Visualization; Work; abstracting; base; body movement; cell adhesion protein; cell motility; cofilin; expiration; gene product; human subject; imaging; intracellular skeleton; mathematical model; mathematical modeling; molecular imaging; neuronal; neuronal growth; novel; polarized cell; programs; response; retrograde transport; social role; vertebrata",Regulation of Neuronal Motility: the role of actin filament turnover,,28695,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,20,352654,
7759220,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS028840-20,,NINDS:425581;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"RATNER, NANCY ;",1909133;,5R01NS028840,08/01/1990,01/31/2011,"2',3'-Cyclic-Nucleotide Phosphodiesterases; Affect; Alleles; Allelomorphs; Axon; Basophilic Histiocyte; Basophils, Tissue; Benign; Biological Models; Breeding; CNPase; Cancer stem cell; Cell Culture System; Cell Culture Techniques; Cell Degranulation; Cell Function; Cell Lineage; Cell Locomotion; Cell Migration; Cell Movement; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Migration; Cellular Physiology; Cellular Process; Clonogenic Cell Assay; Collagen; Colony-Forming Units Assay; Coupled; Crosses, Genetic; Data; Development; Disease; Disorder; Dysplasia; EGFR; ERBB Protein; ERBB1; Embryo; Embryonic; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Event; Fibroblasts; Fibrosis; Genetic Alteration; Genetic Change; Genetic Crosses; Genetic defect; Grant; HER1; HTRPY; Hereditary; Human; Human, General; Hypertrophy; In Vitro; Individual; Inherited; Malignant; Malignant - descriptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Mast Cell; Mice; Mice, Transgenic; Microarray Analysis; Microarray-Based Analysis; Model System; Modeling; Models, Biologic; Molecular; Monitor; Mother Cells; Motility; Motility, Cellular; Multiple Neurofibromas; Murine; Mus; Mutation; NRVS-SYS; Nerve; Nerve Sheath Tumors, Peripheral; Nervous; Nervous System; Nervous system structure; Neurilemma Cell; Neurilemmal Cell; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis 1; Neurofibromatosis I; Neurofibromatosis Syndrome; Neurofibromatosis, Peripheral, NF 1; Neurofibromatosis, Peripheral, NF1; Neurofibromatosis, Type 1; Neurofibromatosis, Type I; Neurologic Body System; Neurologic Organ System; Oncogenesis; Peripheral Nerve Sheath Neoplasm; Peripheral Nerves; Peripheral Neurofibromatosis; Phase; Phenotype; Play; Population; Progenitor Cells; Progress Reports; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Recklinghausen Disease of Nerve; Recklinghausen's disease; Recklinghausen's neurofibromatosis; Recruitment Activity; Reports, Progress; Role; Sampling; Schwann Cells; Secondary to; Sorting - Cell Movement; Stem Cell Assay; Stem cells; Subcellular Process; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Intervention; Time; Transforming Growth Factor alpha Receptor; Transgenic Mice; Transgenic Model; Tumor Cell; Tumor Suppressor Proteins; base; c-erbB-1; c-erbB-1 Protein; cell motility; cell type; disease/disorder; dyscrasia; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; genome mutation; inhibitor; inhibitor/antagonist; intervention therapy; loss of function; mast cell; mastocyte; microarray technology; mouse model; mutant; neoplastic cell; neurofibroma; novel; progenitor; proto-oncogene protein c-erbB-1; receptor expression; recruit; social role; sorting; therapeutic target; tumor; tumor suppressor; tumorigenesis; tumorigenic; von Recklinghausen Disease",Mitogenic Activities in Neurofibromatosis,,28840,NCF,Neurogenesis and Cell Fate Study Section,,20,425581,
7758751,R01,NS,5,,02/15/2010,01/31/2011,PA-07-070,5R01NS029029-18,,NINDS:681966;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"GROSSMAN, ROBERT I.;",8479749;,5R01NS029029,08/19/1991,02/14/2013,"2-Hydroxy-N,N,N-trimethylethanaminium; Acquired brain injury; Active Follow-up; Acute; Age; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amentia; Animal Welfare; Apoplexy; Atrophic; Atrophy; Attention Concentration; Au element; Autoregulation; Axon; Basal Ganglia; Basal Nuclei; Bibliography; Blood Vessels; Blood Volume; Body Tissues; Brain; Brain Injuries; Brain Ischemia; CBF; CNS Injury; Causality; Cell Nucleus; Cell Respiration; Cellular Respiration; Central Nervous System Injury; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Chiro-Inositol; Choline; Chronic; Clinical; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Core-Binding Factor; Country; Craniocerebral Trauma; Creatine; Crossmatching, Tissue; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Diagnosis; Diffuse; Diffusion; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Disturbance in cognition; Dysfunction; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Ethics Committees, Research; Etiology; Exhibits; Fatigue; Fe element; Frequencies (time pattern); Frequency; Functional disorder; Gliosis; Glycine, N-(aminoiminomethyl)-N-methyl-; Goals; Gold; H+ element; Head Injuries; Head Trauma; Histocompatibility Testing; Homeostasis; Hydrogen Ions; Hypoxia; Hypoxic; IACUC; INFLM; IQ Deficit; IRBs; Impact, Environmental; Impaired cognition; Impairment; In element; Incidence; Indium; Infiltration; Inflammation; Inflammatory; Injuries, Craniocerebral; Injury; Injury of central nervous system; Inositol; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Iron; Ischemia; Ischemic Encephalopathy; Judgment; Lack of Energy; Lead; Legal patent; Lesion; Link; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; MS (Multiple Sclerosis); MS Lesions; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Markers, Surrogate; Measures; Mediating; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane; Memory; Mesoinositol; Metabolic; Methods; Methods and Techniques; Methods, Other; Metric; Microcirculation; Morbidity; Morbidity - disease rate; Multiple Sclerosis; Multiple Sclerosis Lesions; Multiple Sclerosis, Relapsing-Remitting; Myelin Sheath; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; NMR Imaging; NMR Tomography; Nature; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocognitive; Neurocognitive Deficit; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neuron Degeneration; Neuronal Injury; Neurons; Nuclear Magnetic Resonance Imaging; Nucleus; Outcome Assessment (Health Care); Outcomes Assessment; Oxygen Deficiency; Patents; Pathology; Pathway interactions; Patients; Pb element; Perfusion; Physiological Homeostasis; Physiopathology; Play; Predisposition; Prevalence; Primary Senile Degenerative Dementia; Principal Investigator; Process; Productivity; Programs (PT); Programs [Publication Type]; Protons; Recruitment Activity; Relapsing-Remitting Multiple Sclerosis; Relative; Relative (related person); Reporting; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Risk Factors; Role; Sclerosis, Disseminated; Secondary to; Series; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Stroke; Structure; Surrogate Markers; Susceptibility; Symptoms; T-Cells; T-Lymphocyte; Techniques; Testing; Thalamic structure; Thalamus; Thymus-Dependent Lymphocytes; Time; Tissue Crossmatchings; Tissue Typing; Tissues; Trauma; United States; Vascular Accident, Brain; Venous; Vertebrate Animals; Vertebrates; Wallerian Degeneration; Zeugmatography; abstracting; adult youth; aerobic metabolism; aerobic respiration; axonal degeneration; base; brain attack; brain damage; brain lesion (from injury); central nervous system injury; cerebral blood flow; cerebral circulation; cerebral hypoperfusion; cerebral vascular accident; cerebrocirculation; cognitive dysfunction; cognitive loss; cognitively impaired; cost; dementia of the Alzheimer type; diffusion tensor imaging; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experience; experiment; experimental research; experimental study; expiration; follow-up; gray matter; heavy metal Pb; heavy metal lead; hemodynamics; histocompatibility typing; human subject; improved; in vivo; indexing; innovate; innovation; innovative; insight; insular sclerosis; macrophage; magnetic field; membrane structure; mitochondrial dysfunction; nervous system disorder; neural degeneration; neurodegeneration; neurodegenerative illness; neurological disease; neuron cell death; neuron injury; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; new approaches; normal aging; novel; novel approaches; novel strategies; novel strategy; oxidative damage; oxidative metabolism; pathophysiology; pathway; primary degenerative dementia; programs; recruit; research study; response; secondary degeneration; senile dementia of the Alzheimer type; sex; social role; stroke; substantia alba; substantia grisea; thalamic; theories; thymus derived lymphocyte; tool; vascular; vascular inflammation; vertebrata; white matter; young adult",Quantitative MR Imaging and Proton Spectroscopy in MS,,29029,MEDI,Medical Imaging Study Section,,18,681966,
7769545,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS031826-17,,NINDS:270751;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"DAVIS, BRIAN M;",1901031;,5R01NS031826,05/01/1993,01/31/2012,"21+ years old; Acute; Address; Adult; Affect; Afferent Neurons; Allergy; Autoregulation; BDNF; Behavioral; Blood Coagulation Factor IV; Brain-Derived Neurotrophic Factor; Ca++ element; Calcium; Cell Line; Cell Lines, Strains; CellLine; Cells; Coagulation Factor IV; Data; Development; Dose; Embryo Development; Embryogenesis; Embryonic Development; Exhibits; Exposure to; Factor IV; Family; Family member; Freund's Adjuvant; Freund's Complete Adjuvant; GDNF; GDNF gene; GFAC; Ganglia, Sensory; Gene Products, RNA; Glia; Glial Cells; Goals; Growth Agents; Growth Factor; Growth Factor Receptors; Growth Factors, Proteins; Growth Substances; Heating; Homeostasis; Human, Adult; Hyperalgesia; Hyperalgesic Sensations; Hypersensitivity; INFLM; Image; Immune Targeting; Immunostimulants, adjuvants, Freund's; In Vitro; Inflammation; Injury; Investigators; Kolliker's reticulum; Laboratories; MGC34632; Mammals, Mice; Messenger RNA; Mice; Mice, Transgenic; Murine; Mus; NT-4; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neurons, Afferent; Neurons, Sensory; Nociception; Nociceptors; Non-neuronal cell; Pain; Painful; Persistent pain; Phenotype; Physiological Homeostasis; Play; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proto-Oncogene, Growth Factor Receptor; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Receptor Protein; Research; Research Personnel; Researchers; Ribonucleic Acid; Role; Sensory Cell Afferent Neuron; Sensory Ganglia; Severities; Signal Pathway; Stimulus; Testing; Time; Transgenic Mice; adult human (21+); critical period; cultured cell line; experiment; experimental research; experimental study; heat stimulus; hyperalgia; imaging; in vivo; inflammatory pain; mRNA; member; nerve cement; neuron development; neuronal; neurotrophic factor; neurotrophin; neurotrophin 4; neurturin; neutrophin; nociceptive; nrtn protein; overexpression; patch clamp; persephin; postnatal; prenatal; programs; receptor; receptor expression; research study; response; social role; unborn",Role of Growth Factors in Persistent Pain,,31826,ZRG1,Special Emphasis Panel,,17,270751,
7760610,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS032123-15,,NINDS:367074;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROSURGERY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"CHESLER, MITCHELL ;",1899220;,5R01NS032123,09/01/1993,01/31/2013,"2S-isocapryloyl-3S-hydroxymethyl-gamma-butyrolactone; A-factor; A-factor (Streptomyces); ATP Dependent Proton Translocase; ATP phosphohydrolase (H+-transporting); Acidosis; Acids; Address; Adenosine Triphosphatase Complex; Alkalinization; Alkalosis; Ammon Horn; Animal Welfare; Apoplexy; Astrocytes; Astrocytus; Astroglia; Asystole; Automobile Driving; Behavior; Bibliography; Bicarbonates; Blood Coagulation Factor IV; Body Tissues; Brain; Brain Hypoxia-Ischemia; Buffers; CO2; Ca++ element; Calcium; Carbon Dioxide; Carbonate hydro-lyase; Carbonic Anhydrases; Carbonic Anhydride; Cardiac Arrest; Catalysis; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chloride; Chloride Ion; Chlorides; Cl- element; Coagulation Factor IV; Common Rat Strains; Complement; Complement Proteins; Cornu Ammonis; Country; Cytosol; Data; Dependence; Drivings, Automobile; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Enzymes; Equilibrium; Equipment; Ethics Committees, Research; Evolution; Extracellular Fluid; Extracellular Space; F(0)F(1)-ATP Synthase; F(1)F(0)-ATPase; F0F1 ATPase; F1F0 ATPase Complex; Factor IV; Feedback; Gene Deletion; Genes; Glia; Glial Cells; H(+)-ATPase; H(+)-Transporting ATP Synthase; H(+)-Transporting ATPase; H(+)ATPase Complex; H+-Translocating ATPase; HCO3; Heart Arrest; Hippocampus; Hippocampus (Brain); Hirudinea; Hydration; Hydration status; Hydrogen Carbonates; Hypoxia; Hypoxia-Ischemia, Brain; Hypoxic; IACUC; IRBs; Image; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercellular Fluid; Intercellular Space; Intermediary Metabolism; International; Interstitial Fluids; Kinetic; Kinetics; Knock-out; Knockout; Kolliker's reticulum; L-factor (Streptomyces); Leeches; Liquid substance; METBL; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rats; Masks; Membrane; Membrane Potentials; Metabolic Processes; Metabolism; Methods; Methods and Techniques; Methods, Other; Mice; Murine; Mus; Na element; Names; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Oxygen Deficiency; PCR; Phylogeny; Physiology; Play; Polymerase Chain Reaction; Predisposition; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Proton-Translocating ATPase Complexes; Proton-Translocating ATPases; Rat; Rattus; Reaction; Regulation; Relative; Relative (related person); Research; Research Ethics Committees; Research Resources; Resources; Resting Potentials; Role; Sodium; Stroke; Surface; Susceptibility; Synapses; Synaptic; System; System, LOINC Axis 4; Techniques; Testing; Time; Tissues; Transmembrane Potentials; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Vertebrate Animals; Vertebrates; Whole-Cell Recordings; abstracting; balance; balance function; base; brain attack; carbonate dehydratase; cerebral vascular accident; driving; experiment; experimental research; experimental study; expiration; extracellular; falls; fluid; gene deletion mutation; hippocampal; human subject; hydrogen transporting ATP synthase; hypoxia ischemia; imaging; insight; liquid; membrane structure; mitochondrial ATPase; nerve cement; neural; neuronal; programs; relating to nervous system; research study; response; social role; stem; stroke; traumatic brain damage; vertebrata",Dynamics of pH Regulation in the Brain,,32123,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,15,367074,
7767658,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS032151-15,,NINDS:306002;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RANSOHOFF, RICHARD M;",1864157;,5R01NS032151,05/01/1994,01/31/2014,"Address; Affect; Alleles; Allelomorphs; Antibodies; Biscyclohexanone Oxaldihydrazone; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood leukocyte; Blood monocyte; Body Tissues; Bone Marrow; Brain; CDw128b; CDw128b Antigens; CMKAR2; CNS Diseases; CNS disorder; CXC Chemokine Receptor 2; CXCR2; CXCR2 Protein; Cell Communication and Signaling; Cell Signaling; Cells; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Chemokine (C-X-C) Receptor 2; Chimera; Chimera organism; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Complement; Complement Proteins; Complex; Cuprizone; Cytokines, Chemotactic; Data; Demyelinations; Drug usage; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Encephalon; Encephalons; Ethanedioic acid, bis(cyclohexylidenehydrazide); Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; GRO/MGSA Receptor; Genetic; Glia; Glial Cells; Grant; Hematogenous; Heterophil Granulocyte; High Affinity Interleukin 8 Receptor Type B; Homologous Chemotactic Cytokines; IL-8RB; IL-8Rbeta; IL8 Receptor Type 2; IL8R2; IL8RB; IL8RB gene; INFLM; In Vitro; Individual; Inflammation; Inflammatory; Intercrines; Interleukin 8 Receptor Beta; Interleukin 8 Receptor Type 2; Interleukin-8 Receptor Type B; Interleukin-8 Receptors B; Interleukin-8B Receptor; Intracellular Communication and Signaling; Kolliker's reticulum; Lesion; Leukocytes; Ligands; Liposomal; Liposomes; Lung diseases; Lysolecithins; Lysophosphatidylcholines; MS (Multiple Sclerosis); Mammals, Mice; Marrow Neutrophil; Marrow leukocyte; Marrow monocyte; Mediating; Mice; Modeling; Molecular; Mother Cells; Multiple Sclerosis; Murine; Mus; Myelin; Myeloencephalitis; Myelogenous; Myeloid; Myeloid Cells; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Non-neuronal cell; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Outcome; Pathway interactions; Performance; Peripheral; Phenotype; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Progenitor Cells; Protocol; Protocols documentation; Pulmonary Diseases; Pulmonary Disorder; Receptor Protein; Receptors, CXCR2; Relative; Relative (related person); Reporting; Research; Resistance; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Leukocytes; Role; SIS cytokines; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Stem cells; Tissues; White Blood Cells; White Cell; autoimmune encephalomyelitis; base; biological signal transduction; brain cell; cell type; chemoattractant cytokine; chemokine; chemokine receptor; clinical investigation; drug use; experiment; experimental research; experimental study; in vitro Model; in vivo; insight; insular sclerosis; lung disorder; macrophage; monocyte; nerve cement; neuronal; neutrophil; novel; pathway; progenitor; public health relevance; receptor; repair; repaired; research study; resistant; response; social role; white blood cell; white blood corpuscle",Chemokines in CNS inflammation," This grant focuses on CXCR2, a cellular receptor present both on inflammatory white blood cells and brain cells. CXCR2 both promotes myelin destruction and hinders myelin repair. Our studies will address the fundamental role of CXCR2 in demyelination and remyelination, by using novel models including in-vitro brain slices and genetically modified mice, allowing the receptor to be removed either from inflammatory white blood cells or from CNS cells. Ongoing clinical trials for pulmonary disease use drugs that block CXCR2 and our studies will provide essential data for designing clinical trials of CXCR2 blockade in MS.",32151,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,15,306002,
7763941,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS033221-12,,NINDS:330118;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NEUROSURGERY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"FRIED, ITZHAK ;",1886531;,5R01NS033221,09/16/1996,01/31/2012,"Abscission; Achievement; Achievement Attainment; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Applications Grants; Area; Association Learning; Brain; Categories; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Code; Coding System; Complex; Cornu Ammonis; Cues; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Doctor of Medicine; Doctor of Philosophy; Electrodes; Electrodes, Implanted; Encephalon; Encephalons; Entorhinal Area; Entorhinal Cortex; Environment; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Episodic memory; Episodic memory, function; Event; Excision; Extirpation; Face; Fire - disasters; Fires; Free Association; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Grant Proposals; Grants, Applications; Health; Hippocampus; Hippocampus (Brain); Human; Human, General; Implanted Electrodes; Individual; Intracellular Communication and Signaling; Investigators; Light; Literature; M.D.; MRI, Functional; Magnetic Resonance Imaging, Functional; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Memory; Memory Deficit; Memory impairment; Modeling; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurosciences; Patients; Pattern; Performance; Persons; Ph.D.; PhD; Phase; Photoradiation; Position; Positioning Attribute; Prevalence; Primary Senile Degenerative Dementia; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Relative; Relative (related person); Removal; Research; Research Personnel; Research Resources; Researchers; Resolution; Resources; Retrieval; Rodent; Rodentia; Rodentias; Role; Seizure Disorder; Seizures; Series; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Stimulus; Structure; Structure of entorhinal cortex; Surgical Removal; Temporal Lobe; Temporal Lobe Epilepsy; Testing; Time; Work; abstracting; base; biological signal transduction; dementia of the Alzheimer type; disease/disorder; entorhinal cortex; epilepsia; epileptiform; epileptogenic; experience; fMRI; facial; flexibility; hippocampal; human subject; interest; memory process; model organism; nervous system disorder; neural; neurological disease; neuronal; neuronal patterning; non-human primate; nonhuman primate; novel; primary degenerative dementia; programs; relating to nervous system; relational memory; resection; response; senile dementia of the Alzheimer type; social role; spatial navigation; success; temporal cortex; temporal lobe/cortex; virtual reality; visual memory; visual stimulus; way finding; wayfinding",Neuronal Correlates of Memory in the Human Temporal Lobe,,33221,LAM,Neurobiology of Learning and Memory Study Section,,12,330118,
7753165,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS033323-12,,NINDS:327260;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NASHVILLE,UNITED STATES,PHARMACOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"EMESON, RONALD B.;",1894946;,5R01NS033323,06/01/1995,01/31/2011,"3' Untranslated Regions; 3'UTR; ADAR2; ADARB1 protein; Ablation; Address; Adenosine; Adrenal Gland Hyperfunction; Adrenocortical Hyperfunction; Affect; Alternate Splicing; Alternative Splicing; Animals; Behavioral; Biochemical; Biological Models; Body Tissues; Brain; Brain region; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Central Nervous System; Chemicals; DRADA2b protein; Deaminase; Degradation, RNA; Encephalon; Encephalons; Energy Expenditure; Energy Metabolism; Enzymes; Eukaryota; Eukaryote; Event; Expression Profiling; Expression Signature; Feeding behaviors; Functional RNA; Gated Ion Channel; Gene Expression; Gene Expression Profile; Gene Products, RNA; Generalized Growth; Growth; Human; Human, General; Hyperadrenalism; Hyperadrenocorticism; Hypercorticism; Hyperglycemia; Hyperphagia; Ingestive Behavior; Injury; Inosine; Intermediary Metabolism; Ion Channel; Ionic Channels; Ions; Isoforms; Kinetic; Kinetics; Laboratories; Lead; Ligands; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Membrane Channels; Messenger RNA; Metabolic Processes; Metabolism; Mice; Mice, Mutant Strains; Mice, Transgenic; Model System; Modeling; Models, Biologic; Modification; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mutant Strains Mice; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System Physiology; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurologic function; Neurological function; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Non-Coding; Non-Coding RNA; Nuclear; Obesity; Overeating; Pathway interactions; Pattern; Pb element; Peripheral; Physiologic; Physiological; Play; Pre-mRNA; Predisposition; Production; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; RED1 (enzyme); RNA; RNA Degradation; RNA Editing; RNA Editings; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA Splicing, Alternative; RNA Stability; RNA, Messenger; RNA, Messenger, Editing; RNA, Messenger, Precursors; RNA, Non-Polyadenylated; Receptor Protein; Receptors, Neurohumor; Regulation; Repetitive Element; Repetitive Regions; Repetitive Sequence; Ribonucleic Acid; Role; Seizures; Subcellular Process; Susceptibility; System; System, LOINC Axis 4; Tissue Growth; Tissues; Transcript; Transgenes; Transgenic Animals; Transgenic Mice; V (voltage); adenosine deaminase that acts on RNA; adiposity; base; corpulence; corpulency; corpulentia; dADAR; double-stranded RNA-specific adenosine deaminase; dsRNA adenosine deaminase; dsRNA-specific adenosine deaminase; energy balance; eukaryotida; feeding; feeding-related behaviors; gene expression signature; gene product; heavy metal Pb; heavy metal lead; hypercortisolism; hyperglycemic; insight; kainate; mRNA; mRNA Precursor; molecuar profile; molecular signature; mouse model; mouse mutant; mutant; nervous system function; neuronal; novel; nutrient intake activity; obese; obese people; obese person; obese population; ontogeny; overexpression; pathway; polyphagia; premRNA; protein expression; receptor; social role; transcriptome; transgene expression; voltage",Regulation of RNA Editing in the CNS,,33323,ZRG1,Special Emphasis Panel,,12,327260,
7758269,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS033997-13,,NINDS:302566;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,NEUROLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"FERRIERO, DONNA M.;",6113692;,5R01NS033997,04/01/1996,01/31/2012,"0-11 years old; 0-6 weeks old; 21+ years old; Acquired brain injury; Active Oxygen; Address; Adult; Affect; Age; Ammon Horn; Animals; Apoptotic; Binding; Binding (Molecular Function); Biological Preservation; Blood Vessels; Blood flow; Blotting, Western; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Cell Communication and Signaling; Cell Death; Cell Signaling; Cells; Cerebral Palsy; Child; Child Youth; Children (0-21); Cornu Ammonis; D-Glucose; Dextrose; ECSF; EMSA; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Epilepsy; Epileptic Seizures; Epileptics; Epoetin; Equilibrium; Erythropoietin; GFAC; Gel; Gene Expression; Gene Targeting; Gene Transcription; Generalized Growth; Genes; Genetic; Genetic Transcription; Glucose; Glutathione[{..}]hydrogen-peroxide oxidoreductase; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H2O2; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Hippocampus; Hippocampus (Brain); Human, Adult; Human, Child; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypoxia; Hypoxia-Ischemia, Brain; Hypoxic; Immunologic, Luciferase; In Vitro; Infant, Newborn; Injury; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Ischemia; Ischemic Preconditioning; Literature; Luciferases; METBL; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Mental Retardation; Messenger RNA; Metabolic Processes; Metabolism; Molecular Interaction; Mononitrogen Monoxide; Necrosis; Necrotic; Neonatal; Neonatal Brain Injury; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Injury; Neurons; Newborn Infant; Newborns; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Outcome; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidizing Agents; Oxygen; Oxygen Deficiency; Oxygen Radicals; Pathway interactions; Peptidyl Prolyl Hydroxylase; Phosphorylation; Preconditionings, Ischemic; Preservation, Biologic; Preservation, Biological; Pro-Oxidants; Process; Procollagen Prolyl 4-Hydroxylase; Procollagen-L-proline,2-oxoglutarate[{..}]oxygen oxidoreductase; Procollagen-Proline Dioxygenase; Production; Programs (PT); Programs [Publication Type]; Proline Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Prolyl 4-Hydroxylase; Prolyl Hydroxylase; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Phosphorylation; Proteins; Protocollagen Prolyl Hydroxylase; Public Health; RNA Expression; RNA, Messenger; RNA, Small Interfering; Reactive Oxygen Species; Recovery; Redox; Regulation; Research Personnel; Researchers; Role; Running; Seizure Disorder; Severities; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Molecule; Small Interfering RNA; Targetings, Gene; Testing; Therapeutic; Time; Tissue Growth; Toxic effect; Toxicities; Trans-Activation (Genetics); Transactivation; Transcription; Transcription, Genetic; Up-Regulation; Up-Regulation (Physiology); Upregulation; VEGFs; Vascular Endothelial Growth Factors; Vegf; Western Blotting; Western Blottings; Western Immunoblotting; Work; adult human (21+); balance; balance function; behavior test; behavioral test; biological signal transduction; brain damage; brain lesion (from injury); brain volume; children; disability; electron acceptor; endothelial cell derived relaxing factor; epilepsia; epileptiform; epileptogenic; erythrocyte colony stimulating factor; experiment; experimental research; experimental study; gene product; glutathione peroxidase; hematopoietin; hippocampal; hypoxia inducible factor 1; hypoxia ischemia; hypoxic ischemic encephalopathy; in vivo; inhibitor; inhibitor/antagonist; injury response; kinase inhibitor; knock-down; mRNA; necrocytosis; neonatal hypoxia-ischemia; neonatal hypoxic-ischemic brain injury; neuron injury; neuronal; neuroprotection; newborn human (0-6 weeks); ontogeny; overexpression; oxidation reduction reaction; pathway; preconditioning; preservation; programs; protein blotting; public health medicine (field); repair; repaired; research study; response; response to injury; siRNA; social role; trend; vascular; youngster",Oxidant Mechanisms in Neonatal Brain Injury,,33997,DBD,Developmental Brain Disorders Study Section,,13,302566,
7760195,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS034435-15,,NINDS:330562;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW BRUNSWICK,UNITED STATES,BIOCHEMISTRY,06,001912864,US,NJ,08901,RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK,"DRISCOLL, MONICA A.;",1886506;,5R01NS034435,08/01/1995,01/31/2014,"Acidosis; Affect; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Apoptotic; Autoregulation; Biological; Biological Models; Blood Coagulation Factor IV; Brain; C elegans; C.elegans; Ca++ element; Ca2+-Activated Protease; Caenorhabditis elegans; Calcium; Calcium Binding; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Binding Proteins; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cathepsins; Cations; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell membrane; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Clinical Treatment; Coagulation Factor IV; Cytoplasmic Membrane; DISSEC; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Desminase; Development; Disease; Disorder; Dissection; Dysfunction; EF Hand Motifs; EF Hands; ENaC; ENaC (epithelial Na+ channel); Encephalon; Encephalons; Enhancers; Esteroproteases; Experimental Models; Experimental Models, Other; Factor IV; Family; Foundations; Functional disorder; GeneHomolog; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic Screening; Genetic defect; Goals; Homeostasis; Homolog; Homologous Gene; Homologue; Human; Human Identifications; Human, General; Identifications, Human; Image; Individual; Injury; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigation; Ion Channel; Ionic Channels; Ischemia; Life; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Membrane Channels; Mice; Model System; Modeling; Models, Biologic; Models, Experimental; Models, Genetic; Molecular; Molecular Genetic; Molecular Genetics; Monitor; Murine; Mus; Mutation; Necrosis; Necrotic; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neuronal Injury; Neurons; Neuroses; Neurotic Disorders; Organism; Outcome; Papain-Like Cysteine Protease; Pathology; Pathway interactions; Peptidases; Peptide Hydrolases; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Plasma Membrane; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Psychoneuroses; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Relative; Relative (related person); Reporter; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Societies; Stimulus; Stroke; System; System, LOINC Axis 4; Testing; Toxic effect; Toxicities; Translating; Translatings; Vascular Accident, Brain; Work; biological signal transduction; brain attack; cerebral vascular accident; combat; design; designing; disease/disorder; effective intervention; effective therapy; epithelial Na+ channel; experiment; experimental research; experimental study; gene product; genome mutation; genome-wide; imaging; in vivo; interventional strategy; language translation; living system; model organism; mutant; necrocytosis; nervous system disorder; neurodegenerative illness; neurological disease; neuron cell death; neuron injury; neuron loss; neuron toxicity; neuronal; neuronal cell death; neuronal loss; neuronal toxicity; neurotic; neuroticism; neurotoxicity; new approaches; novel; novel approaches; novel strategies; novel strategy; parallel processing; pathophysiology; pathway; plasmalemma; public health relevance; research study; roundworm; social role; stroke; trial regimen; trial treatment",Mechanisms of Degenerative Cell Death in C. elegans," Stroke, ischemia, acidosis, physical injury to neurons, and neurodegenerative disease can induce a type of neuronal death called necrosis. Necrotic neuronal loss is a thus major clinical problem--yet there are currently no effective treatments that combat neuronal necrosis, in part because necrosis mechanisms are not well defined. We work with a simple genetic animal model for channel hyperactivation-induced necrosis to identify genes that are essential for, promote, or diminish neuronal necrosis. There is strong evidence that necrosis mechanisms are conserved from simple animals to humans (for example, the mammalian homolog of the channel we study is a major contributor to neuronal loss in mouse stroke models). Molecularly identifying necrosis modulator genes and determining how they work to affect necrosis outcomes will provide much needed understanding of basic necrosis mechanisms and should inspire novel approaches toward potential anti-necrosis therapies.",34435,NOMD,Neural Oxidative Metabolism and Death Study Section,,15,330562,
7760968,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS034661-13,,NINDS:424153;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,NONE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"RUBENSTEIN, JOHN L. R.;",1891058;,5R01NS034661,09/01/1996,01/31/2011,"Agonist; Applications Grants; Bone-Derived Transforming Growth Factor; Brain; Cell Communication and Signaling; Cell Death; Cell Signaling; Cognition; DNA Synthesis Factor; Development; Developmental Process, Multicellular; Disease; Disorder; ECGF; Ectopic Expression; Emotions; Encephalon; Encephalons; Endothelial Cell Growth Factor; FGF; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Gene Expression; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Grant Proposals; Grants, Applications; HBGF; Housing; Intracellular Communication and Signaling; Investigation; Mammals, Mice; Mice; Mice, Mutant Strains; Milk Growth Factor; Molecular; Morphogenesis; Motor Cortex; Murine; Mus; Mutant Strains Mice; Mutation; Nature; Neocortex; Nervous System, Brain; Pattern; Phenotype; Platelet Transforming Growth Factor; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure; TGF B; TGF-beta; TGFbeta; Telencephalon; Testing; Tissue Development Process; Transforming Growth Factor beta; biological signal transduction; disease/disorder; dosage; emx2; emx2 gene product; emx2 protein; emx2 protein, vertebrate; experiment; experimental research; experimental study; frontal cortex; frontal lobe; genome mutation; histogenesis; homotypical cortex; insight; isocortex; motor control; mouse mutant; mutant; necrocytosis; neopallium; neuroepithelium; neuropsychiatric; neuropsychiatry; research study; social role; transcription factor",Genetic Studies of Cortex Structure and Development,,34661,NCF,Neurogenesis and Cell Fate Study Section,,13,424153,
7769522,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS034709-14,,NINDS:334045;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,NEUROSURGERY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"KEEP, RICHARD F;",1897193;,5R01NS034709,07/25/1996,01/31/2014,"Address; Affect; Alteplase; Antioxidants; Apoplexy; Astrocytes; Astrocytus; Astroglia; Blood; Blood - brain barrier anatomy; Blood Vessels; Blood leukocyte; Blood-Brain Barrier; Brain; Brain Hemorrhage, Cerebral; Cells; Cellular injury; Cerebral Hemorrhage; Cerebral Ischemia; Cerebral Parenchymal Hemorrhage; Cerebral Stroke; Cerebral hemisphere hemorrhage; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Chlorohemin; Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-; Cruciform Vegetables; Cystine; D-Glucose; DHQU; DIA4; DTD; Data; Defense Mechanisms; Dehydrogenases; Dextrose; Disease; Disorder; Dropsy; Dysfunction; Edema; Encephalon; Encephalons; Endothelial Cells; Endothelium; Event; Exposure to; Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-5-13)-; Ferriheme Chloride; Ferriprotoporphyrin IX Chloride; Ferritin; Fibroblasts; Free Radicals; Functional disorder; Glucose; Glutamates; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; H ferritin; HO-1 enzyme; HO1; HO2; HSP32; Haem Oxygenase; Hemato-Encephalic Barrier; Heme Oxygenase (Decyclizing); Heme,hydrogen-donor[{..}]oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating); Hemin; Hemoglobin; Hemorrhage, Cerebrum; Hydrops; INFLM; In Vitro; Inflammation; Inflammation Mediators; Injury; Intracerebral Hemorrhage; Ischemia; Ischemic Preconditioning; Ischemic Stroke; Killings; L-Cystine; L-Glutamate; LPS; Leukocytes; Link; Lipopolysaccharides; Marrow leukocyte; Messenger RNA; Methods; Molecular; NF-E2-related factor 2; NMOR1; NMORI; NQO1; NQO1 gene; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Nrf2 protein; O element; O2 element; Occluding Junctions; Oxidative Stress; Oxidoreductase; Oxygen; PLAT; Peptide Biosynthesis, Ribosomal; Physiopathology; Preconditionings, Ischemic; Production; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Proteins; Protohemin; Protohemin IX; QR1; Quinine; RNA, Messenger; RNA, Small Interfering; Recombinant Tissue Plasminogen Activator; Reductases; Regulation; Reperfusion Therapy; Reticuloendothelial System, Blood; Reticuloendothelial System, Leukocytes; Role; Small Interfering RNA; Stimulus; Stress; Stroke; Sulfaforaphane; Sulforaphane; System; System, LOINC Axis 4; T-Plasminogen Activator; TTPA; Therapeutic; Tight Junctions; Tissue Activator D-44; Tissue Plasminogen Activator; Tissue-Type Plasminogen Activator; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; White Blood Cells; White Cell; Zonula Occludens; anti-oxidant; brain attack; cell damage; cell injury; cell type; cerebral vascular accident; cruciferous vegetable; deprivation; design; designing; disease/disorder; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; heme oxygenase-1; hemeoxygenase 1; in vivo; interest; mRNA; methylsulfoxybutylisothiocyanate; migration; nervous system disorder; neurological disease; neurotoxic; neurovascular unit; pathophysiology; preconditioning; prevent; preventing; protective effect; protein synthesis; psychological defense mechanism; public health relevance; reperfusion; siRNA; social role; stroke; sulforafan; sulforophane; t-PA; therapeutic target; transcription factor; uptake; vascular; white blood cell; white blood corpuscle",Endogenous and exogenous protection of the BBB in stroke," Lay Summary Brain blood vessels have very specialized functions, forming a blood-brain barrier. Disuption of that barrier occurs in many neurological disorders and injuries, contributing to brain dysfunction. This proposal examines natural defense mechanisms that may protect the blood-brain barrier, how to activate those mechanisms or prevent their inactivation therapeutically.",34709,BINP,Brain Injury and Neurovascular Pathologies Study Section,,14,334045,
7778385,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS034994-13,,NINDS:301130;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEWARK,UNITED STATES,NONE,10,130029205,US,NJ,07102,RUTGERS THE STATE UNIV OF NJ NEWARK,"BUZSAKI, GYORGY ;",1894917;,5R01NS034994,06/01/1995,02/28/2014,"Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Animals; Behavior; Behavioral; Brain; Cells; Cephalic; Cognition Disorders; Cognitive; Common Rat Strains; Cornu Ammonis; Cranial; Cues; Custom; Decision Making; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dysfunction; Encephalon; Encephalons; Entorhinal Area; Entorhinal Cortex; Epilepsy; Epileptic Seizures; Epileptics; Episodic memory; Episodic memory, function; Functional disorder; Future; Goals; Hippocampus; Hippocampus (Brain); Human; Human, General; Length; Life; Light; Link; Mammals, Primates; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Memory; Mind; Modeling; Motion; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Output; Pattern; Performance; Phase; Photoradiation; Physiopathology; Population; Primary Senile Degenerative Dementia; Primates; Process; Property; Property, LOINC Axis 2; Psyche structure; Rat; Rattus; Rodent; Rodentia; Rodentias; Role; Route; Running; Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Seizure Disorder; Shapes; Source; Spatial Behavior; Structure; Structure of entorhinal cortex; Synapses; Synaptic; Testing; Time; Work; cell assembly; cell behavior; cognitive disease; cognitive disorder; cognitive function; dementia of the Alzheimer type; dementia praecox; design; designing; entorhinal cortex; epilepsia; epileptiform; epileptogenic; experience; experiment; experimental research; experimental study; hippocampal; in vivo; insight; internal control; memory recall; mental; neuronal; neurophysiology; neuropsychological; pathophysiology; primary degenerative dementia; public health relevance; research study; schizophrenic; senile dementia of the Alzheimer type; social role",Network cooperation in the hippocampus in vivo," Using large-scale recording of neuronal activity in the rat, we will examine the hypothesis that self-organized sequences of neuronal assemblies in the hippocampus underlie memory recall and/or planning. Similar internally generated cell assembly sequences may be responsible for several other cognitive functions, including planning and logical reasoning. Dysfunction of self-organized cellular-synaptic mechanisms may underline Alzheimer's disease, schizophrenia and other cognitive diseases. 1",34994,LAM,Neurobiology of Learning and Memory Study Section,,13,301130,
7759148,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS035032-14,,NINDS:271974;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,UNIVERSITY PARK,UNITED STATES,MISCELLANEOUS,05,003403953,US,PA,16802,PENNSYLVANIA STATE UNIVERSITY-UNIV PARK,"LATASH, MARK L.;",1873010;,5R01NS035032,02/01/1997,01/31/2011,"Address; Articulation; Back; Be element; Be++ element; Beryllium; Biological Models; Central Nervous System; Characteristics; Clinical; Complement; Complement Proteins; Data; Development; Digit; Digit structure; Disease; Disorder; Dorsum; Down Syndrome; Down's Syndrome; Downs Syndrome; Drops; Elements; Evolution; Fingers; Generations; Goals; Grips; Hand; History; Human; Human, General; Idiopathic Parkinson Disease; Impairment; In element; Indium; Individual; Instruction; Investigators; Joints; Journals; Langdon Down syndrome; Lewy Body Parkinson Disease; Life; Magazine; Man (Taxonomy); Man, Modern; Mechanics; Model System; Modeling; Models, Biologic; Modification; Mongolism; Monitor; Motor; Movement; Muscle; Muscle Tissue; Nervous; Nervous System, CNS; Neuraxis; Output; Paper; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Pattern; Performance; Persons; Phase; Physiologic pulse; Pilot Projects; Population; Posture; Pressure; Pressure- physical agent; Primary Parkinsonism; Process; Production; Productivity; Programs (PT); Programs [Publication Type]; Pulse; Reaction Time; Recording of previous events; Research; Research Personnel; Researchers; Response RT; Response Time; Role; Simulate; Slice; Staging; Stimulus; Structure; Surface; System; System, LOINC Axis 4; Testing; Time; Time Study; Trisomy 21; Variant; Variation; base; body movement; chromosome 21 trisomy syndrome; congenital acromicria syndrome; design; designing; disease/disorder; experiment; experimental research; experimental study; feeding; grasp; indexing; instrument; member; morbus Down; neural; pilot study; pressure; programs; pseudohypertrophic progressive muscular dystrophy; psychomotor reaction time; relating to nervous system; research study; response; sensor; social role; tool; trisomy 21 syndrome",THE ORGANIZATION OF A SIMPLE SYNERGY,,35032,ZRG1,Special Emphasis Panel,,14,271974,
7763814,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS035107-12,,NINDS:314016;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,PATHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"ROTH, KEVIN AARON;",1897184;,5R01NS035107,05/01/1996,01/31/2011,"0-11 years old; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-; APAF1 Protein; Absolute ethanol; Acute; Affect; Agonist; Alcohol, Ethyl; Anesthestic Drugs; Anesthetic Agents; Anesthetic Drugs; Anesthetics; Apaf-1; Apaf-1 protein; Apaf-1L protein; Apaf-3 protein; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Apoptotic Cysteine Protease MCH2; Apoptotic Protease Activating Factor; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; Apoptotic Protease Mch-2; Attenuated; Autophagocytosis; BH3 Domain; Brain; CASP-3; CASP3; CASP6 Protein; CASP9 Protein; CASPASE 6, Apoptosis-Related Cysteine Protease; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase 9, Apoptosis-Related Cysteine Protease; Causality; Cell Communication and Signaling; Cell Culture Techniques; Cell Death, Programmed; Cell Signaling; Cell-Death Protease; Cells; Cessation of life; Child; Child Youth; Children (0-21); Complement; Complement Proteins; Cysteine Protease CPP32; Data; Death; Development; Dorsal Root Ganglia; Drugs; ETOH; Embryo; Embryonic; Embryonic Nervous System; Encephalon; Encephalons; Ethanol; Etiology; Event; Exhibits; Exposure to; Family member; Fetal Alcohol Syndrome; Funding; Ganglia, Spinal; Gasser's Ganglion; Gasserian Ganglion; Gene Targeting; Genes; Genes, p53; Genetic; Genotoxins; Goltz-Gorlin syndrome; Grain Alcohol; Grant; Human; Human, Child; Human, General; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; ICE-like protease; In Vitro; Intracellular Communication and Signaling; Investigation; Investigators; Link; MK 801; MK801; Mammals, Mice; Man (Taxonomy); Man, Modern; Mch6 protein; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Medulla Spinalis; Methylcarbinol; Mice; Mitochondria; Modeling; Molecular; Morphogenesis; Murine; Mus; Mutagens; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA receptor antagonist; NRVS-SYS; Neonatal; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; P53; PARP Cleavage Protease; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Play; Population; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Receptor Protein; Receptor Signaling; Relative; Relative (related person); Reporting; Reports, Progress; Research Personnel; Researchers; Resistance; Role; SCA-1; SREBP Cleavage Activity 1; Seizures; Semilunar Ganglion; Series; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Spinal Ganglia; Staurosporine; Stimulus; Structure of trigeminal ganglion; TP53; TP53 gene; TRP53; Targetings, Gene; Testing; Trigeminal Ganglias; Trigeminal Ganglion; Tumor Protein p53 Gene; Up-Regulation; Up-Regulation (Physiology); Upregulation; Withdrawal; Yama; Yama protein; alcohol effect; alcohol exposed; alcohol exposure; alcoholic embryopathy; apoptosis of neuronal cells; apoptotic protease-activating factor 1; autophagy; base; biological signal transduction; caspase; caspase-3; caspase-6; caspase-9; children; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; disease causation; disease etiology; disease/disorder etiology; disorder etiology; dorsal root ganglion; drug/agent; embryofetal alcohol syndrome; embryofetal alcohol syndrome (EFAS); embryopathia alcoholica; ethanol effect; ethanol exposed; ethanol exposure; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; fetal alcohol syndrome (FAS); genotoxic agent; in vivo; insight; mRNA Expression; member; mitochondrial; neonate; nervous system development; neural precursor cell; neuron apoptosis; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal apoptosis; neuronal cell death; neuronal loss; neuronal toxicity; neuropathology; neurotoxic; neurotoxicity; neurotrophic factor; neurotrophin; neutrophin; pathway; prevent; preventing; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; receptor; research study; resistant; response; social role; youngster",Bcl-X Dependent Neuropathology,,35107,ZRG1,Special Emphasis Panel,,12,314016,
7760554,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS035130-06,,NINDS:334590;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"YUE, GUANG H;",1871725;,5R01NS035130,02/01/1997,01/31/2013,"Address; Aged 65 and Over; Aging; Animal Welfare; Artifacts; Automobile Driving; Bibliography; Blinking; Brain; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive; Contracting Opportunities; Contracts; Country; Critiques; Data; Decision Trees; Development; Dose; Drivings, Automobile; Drops; Drugs; EEG; Ecological impact; Elbow; Elderly; Elderly, over 65; Electrodes; Electroencephalography; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Exclusion Criteria; Exhibits; Eye; Eyeball; Face; Feedback; Frail Elderly; Frail Elders; Frail Older Adults; Frail Seniors; Frequencies (time pattern); Frequency; HOSP; Home; Home environment; Hospitals; IACUC; IRBs; Imagery; Impact, Environmental; Information Processing, Human; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigators; Mediating; Medication; Mental Processes; Methods; Mind; Monitor; Morphologic artifacts; Morphology; Movement; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscle Weakness; Muscle, Skeletal; Muscle, Voluntary; Muscular Contraction; Muscular Weakness; Neck; Nervous System, Brain; Neurologist; Nurses; Older Adults, Frail; Outcome; Output; Patients; Personnel, Nursing; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Health Services / Rehabilitation; Population; Posture; Principal Investigator; Programs (PT); Programs [Publication Type]; Psyche structure; Qualifying; Recruitment Activity; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Scalp; Scalp structure; Science of neurophysiology; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skeletal Muscle Tissue; Skeletal muscle structure; Specific qualifier value; Specified; Staging; Study Section; Suggestion; Training; Vertebrate Animals; Vertebrates; Visual; Visualization; abstracting; advanced age; biological signal transduction; body movement; bruxing; driving; drug/agent; elders; experiment; experimental research; experimental study; expiration; eye blink; eyeblink; facial; frail older adult; geriatric; human subject; late life; later life; mental; mental imagery; muscle strength; neural mechanism; neuroadaptation; neuromechanism; neurophysiology; novel; older adult; older person; programs; recruit; rehabilitative; research study; senescent; senior citizen; spelling; stem; strength training; teeth clenching; vertebrata",Effects of Mental Training on Voluntary Muscle Strength in Aging,,35130,ZRG1,Special Emphasis Panel,,6,334590,
7763952,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS035533-13,,NINDS:337412;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SEATTLE,UNITED STATES,NEUROSURGERY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"MORRISON, RICHARD S;",1901024;,5R01NS035533,04/01/1997,01/31/2011,"ATF; Actin Filaments; Actins; Acute; Affect; Anti-Oncogenes; Antioncogene Protein p53; Antioncogenes; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; CFL2 gene product; Cell Death; Cell Death, Programmed; Cell Line; Cell Lines, Strains; CellLine; Cellular Matrix; Cellular Tumor Antigen P53; Cessation of life; Chronic; Complement; Complement Proteins; Cytoskeletal Modeling; Cytoskeletal Organization; Cytoskeletal Organization Process; Cytoskeletal Reorganization; Cytoskeletal System; Cytoskeleton; Cytosol; DNA Damage; DNA Injury; DNM1 Gene Product, Dynamin; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dephosphin; Disease; Disorder; Dyn1; Dynamin; Dynamin D100; Dynamin I; Dynamin-1; Dysfunction; Emerogenes; Epilepsy; Epileptic Seizures; Epileptics; Functional disorder; Gene Expression; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, p53; Genotoxic Stress; Glia; Glial Cells; Growth; Individual; Injury; Investigators; Ischemia; Kolliker's reticulum; Laboratories; Ligand Binding Protein; Mediating; Microfilaments; Mitochondria; Mitochondrial Membrane Protein; Mitochondrial Proteins; Modeling; Molecular; Molecular Interaction; Myofilaments; N-Bak protein; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neurons; Non-neuronal cell; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncoprotein p53; P53; Patients; Phosphoprotein P53; Phosphoprotein pp53; Physiopathology; Play; Process; Programs (PT); Programs [Publication Type]; Protein TP53; Protein p53; Proteins; Proteome; Proteomics; RNA Splicing; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Role; Seizure Disorder; Splicing; Stress; Stress, Genotoxic; TP53; TP53 gene; TRP53; Testing; Tissue Growth; Tissue Sample; Tumor Protein p53; Tumor Protein p53 Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Up-Regulation; Up-Regulation (Physiology); Upregulation; activating transcription factor; apoptosis of neuronal cells; brain tissue; cofilin; cofilin 2; cultured cell line; disease/disorder; epilepsia; epileptiform; epileptogenic; gene product; inhibitor; inhibitor/antagonist; injury response; intracellular skeleton; mitochondrial; mitochondrial dysfunction; necrocytosis; nerve cement; neurodegenerative illness; neuron apoptosis; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal apoptosis; neuronal cell death; neuronal loss; neuronal survival; neuronal toxicity; neurotoxicity; oncosuppressor gene; ontogeny; p53 Antigen; p53 Tumor Suppressor; pathophysiology; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; protein distribution; protein expression; response; response to injury; social role; transcription factor",Regulation of Neuronal Survival,,35533,ZRG1,Special Emphasis Panel,,13,337412,
7758753,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS035712-13,,NINDS:368213;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,BIOMEDICAL ENGINEERING,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"MEANEY, DAVID F;",1962738;,5R01NS035712,05/01/1997,01/31/2011,"Actins; Acute; Ammon Horn; Biomechanics; Body Tissues; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular Matrix; Cessation of life; Cornu Ammonis; Coupling; Cytoskeletal System; Cytoskeleton; Data; Death; Dentate Fascia; Dentate Gyrus; Environment; Fascia Dentata; Functional impairment; Grant; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Injury; Intracellular Communication and Signaling; Investigators; JNK; JNK1; JNK1A2; JNK21B1/2; Lead; MAP Kinase 8 Gene; MAPK8; MAPK8 gene; Measures; Mechanics; Mediating; Memory; Modeling; Motion; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; PRKM8; Pathway interactions; Pb element; Phase; Play; Population; Preparation; Programs (PT); Programs [Publication Type]; Pyramidal Cells; Receptor Activation; Receptor Protein; Receptors, N-Methylaspartate; Recombinants; Research; Research Personnel; Researchers; Role; SAPK1; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Stretching; Structure of dentate gyrus; Synapses; Synaptic; Testing; Therapeutic; Tissues; Translating; Translatings; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Work; biological signal transduction; dentate gyrus; experience; functional disability; granule cell; heavy metal Pb; heavy metal lead; hippocampal; in vivo; injured; intracellular skeleton; language translation; necrocytosis; neuronal; pathway; programs; receptor; social role; traumatic brain damage; treatment strategy",Biomechanical Analysis of Traumatic Brain Injury Models,,35712,CND,Clinical Neuroscience and Disease Study Section,,13,368213,
7763238,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS035714-12,,NINDS:308602;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOZEMAN,UNITED STATES,ANATOMY/CELL BIOLOGY,00,625447982,US,MT,59717,MONTANA STATE UNIVERSITY (BOZEMAN),"LEFCORT, FRANCES ;",1879583;,5R01NS035714,07/01/1996,01/31/2014,"Achievement; Achievement Attainment; Afferent Neurons; Autonomic nervous system; Aves; Avian; Behavior; Binding; Binding (Molecular Function); Birds; Blood Pressure; CO2; Carbon Dioxide; Carbonic Anhydride; Causality; Cells; Computer Systems Development; Cues; Data; Detection; Development; Development, Computer Systems; Disease; Disorder; Dorsal; Dorsal Root Ganglia; Dysautonomia, Familial; Dysautonomias; Embryo; Embryonic; Emigrations; Esthesia; Etiology; Event; Familial dysautonomia; Ganglia, Spinal; Gene variant; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Diversity; Genetic Variation; Genetic defect; Goals; HSAN; HSAN Type III; Hereditary Disease; Hereditary Sensory and Autonomic Neuropathy Type III; Hereditary-Sensory and Autonomic Neuropathy Type III; Image; Imaging technology; Lateral; Learning; Life; Mammals, Mice; Medial; Mediating; Mice; Molecular; Molecular Disease; Molecular Interaction; Mother Cells; Murine; Mus; Mutation; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Crest; Neural Crest Cell; Neural tube; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neuropathy, Hereditary and Autonomic, Type III; O element; O2 element; Organism; Oxygen; PNS Diseases; Pain; Painful; Pathology; Peripheral Nerve Diseases; Peripheral Nervous System; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Phenotype; Plasmids; Population; Position; Positioning Attribute; Progenitor Cells; Proteins; Quail; Reagent; Reporter; Reporting; Retroviridae; Retroviruses; Riley-Day Syndrome; Role; Sensation; Sensory; Sensory Cell Afferent Neuron; Sodium Chloride; Sodium chloride (NaCl); Spinal Ganglia; Stem cells; Stereotyping; Stimulus; Sympathetic Ganglia; Systems Development; Technology; Temperature; Time; Transfection; Transgenic Organisms; Type 3 Hereditary Sensory Neuropathy, Dominant; Type III Hereditary Sensory Neuropathy, Dominant; Variant; Variation; Variation (Genetics); Viral; Virus-Retrovirus; Work; allelic variant; autonomic neuropathy; cell type; diabetic; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; dorsal root ganglion; familial autonomic nervous dysfunction; gene product; genetic disorder; genome mutation; hereditary disorder; imaging; in vivo; knock-down; living system; loss of function; migration; mouse model; neural; neuron development; neuronal; precursor cell; progenitor; public health relevance; relating to nervous system; salt; social role; stem; transgenic",DRG Progenitor: Role of extrinsic and intrinsic cues, Our work is focused on understanding how pain-sensing neurons are born and mature. These neurons are essential for life as protection against noxious stimuli that could harm the organism. Achievement of the aims of our proposal will identify cellular and molecular mechanisms that can be applied to the treatment of both developmental and degenerative peripheral neuropathies including Familial dysautonomia and diabetic peripheral neuropathy.,35714,NCF,Neurogenesis and Cell Fate Study Section,,12,308602,
7760180,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS036647-09,,NINDS:337838;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PISCATAWAY,UNITED STATES,NEUROSCIENCES,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"DREYFUS, CHERYL F;",1863661;,5R01NS036647,06/01/1998,01/31/2013,"(Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine; 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; Address; Affect; BDNF; BDNF Receptor; BDNF/NT-3 Growth Factors Receptor; BUdR; Basic Fibroblast Growth Factor Gene; Biscyclohexanone Oxaldihydrazone; Brain-Derived Neurotrophic Factor; BrdU; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CSPG4; CSPG4 gene; Candidate Disease Gene; Candidate Gene; Cells; Cessation of life; Corpus Callosum; Corpus Callosums; Cuprizone; DNA Replication; DNA Synthesis; DNA biosynthesis; Data; Death; Defect; Demyelinating Diseases; Demyelinating Disorders; Demyelinations; Development; Disease; Disorder; Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-; Ethanedioic acid, bis(cyclohexylidenehydrazide); Exhibits; Extracellular Signal-Regulated Kinase Gene; FGF2; FGF2 gene; FGFB; Fibroblast Growth Factor 2 Gene; Funding; GFAC; GP145-TRKB; Gamma interferon; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; IFN-Gamma; IFN-g; IFNG; IL-7; IL7 Protein; Injury; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 7 Precursor; Interleukin-7; Knockout Mice; Lead; Lesion; Life; Literature; Lymphopoietin-1; MAG Protein; MAP Kinase Gene; MAPK; MCSP; MCSPG; MEL-CSPG; MGC34632; MSK16; Mammals, Mice; Mediating; Mediation; Mice; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinase Gene; Modeling; Mother Cells; Murine; Mus; Myelin; Myelin Associated Glycoprotein; Myelin Basic Proteins; NG2; NTRK2; NTRK2 Receptor; Natural regeneration; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurotrophic Factor, Brain-Derived, Receptor; Neurotrophic Tyrosine Kinase Receptor Type 2; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; PDGF; Pathway interactions; Pb element; Phase; Platelet-Derived Growth Factor; Play; Pleural Glycoproteins; Population; Position; Positioning Attribute; Predisposition; Process; Progenitor Cells; Proteins; Proteolipids; Receptor, trkB; Recovery; Regeneration; Research; Research Design; Role; Stem cells; Study Type; Susceptibility; TAM; TRKB; TRKB Tyrosine Kinase; Tamoxifen; Testing; Therapeutic; Therapeutic Agents; Uridine, 5-bromo-2'-deoxy-; Vulnerable Populations; White Matter Disease; Work; basal forebrain; base; design; designing; disease/disorder; gene product; heavy metal Pb; heavy metal lead; in vivo; insight; lFN-Gamma; myelin glycoprotein; neuronal; neurotrophic factor; neurotrophin; neutrophin; oligodendrocyte lineage; pathway; progenitor; public health relevance; regenerate; repair; repaired; response; social role; study design; trait; trkB(gp145) Protein",The Role of Neurotrophins in Oligodendrocyte Function," PROJECT NARRATIVE In demyelinating diseases there is a loss of oligodendrocytes, cells that provide insulating sheaths to neurons. Studies of this application are designed to evaluate roles of the growth factor BDNF in promoting development, survival and function of oligodendrocyte lineage cells during and after a demyelinating lesion. This work may lead to the development of BDNF as a therapeutic agent and to the identification of potential candidate genes for geneticists to test as susceptibility loci for these devastating diseases.",36647,CMBG,Cellular and Molecular Biology of Glia Study Section,,9,337838,
7759214,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS036736-12,,NINDS:295283;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,NEUROLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"CHEN, JUN ;",2088995;,5R01NS036736,06/16/1997,11/30/2012,"AP Endonuclease; AP Lyase; Acquired brain injury; Ammon Horn; Animal Model; Animal Models and Related Studies; Antimorphic mutation; Apoplexy; Apurine-Apyrimidine Endonuclease; Apurinic DNA Endonuclease; Apurinic Endonuclease; Base Excision Repairs; Behavioral; Brain; Brain Injuries; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Culture Techniques; Cell Death; Cells; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Chimera Protein; Chimeric Proteins; Clinical; Common Rat Strains; Complement; Complement Proteins; Cornu Ammonis; D-Glucose; DNA; DNA Base Excision Repair; DNA Damage; DNA Damage Repair; DNA Injury; DNA Lyase (Apurinic or Apyrimidinic); DNA N-glycosidase; DNA Polymerases; DNA Repair; DNA glycosylase; DNA lesion; DNA ligase I; DNA ligase III; DNA-(apurinic or apyrimidinic site) lyase; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Death; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxyribonucleic Acid; Development; Dextrose; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2.7.7.7; Encephalon; Encephalons; Endodeoxyribonuclease (Apurinic or Apyrimidinic); Enzymes; Fusion Protein; Future; Gene Delivery; Gene Transcription; Genes; Genetic Transcription; Genomics; Glucose; Hippocampus; Hippocampus (Brain); In Vitro; Injury; Ischemia; Ischemic Brain Injury; Ischemic Neuronal Injury; Ischemic Preconditioning; Ischemic Stroke; Knockout Mice; L-Serine; Lead; Lesion; Mammals, Rats; Mediating; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear; Null Mouse; O element; O2 element; Outcome; Oxidation-Reduction; Oxidative Stress; Oxygen; PKC; Pathway interactions; Pb element; Peptides; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Preconditionings, Ischemic; Predisposition; Process; Protein Kinase C; Proteins; RNA Expression; RNA, Small Interfering; Rat; Rattus; Redox; Regulation; Repairs, Base Excision; Reperfusion Therapy; Role; Serine; Signal Pathway; Site; Small Interfering RNA; Stimulus; Stroke; Susceptibility; Testing; Transcription; Transcription, Genetic; Transgenic Organisms; Unscheduled DNA Synthesis; Vascular Accident, Brain; Work; base; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; cytotoxic; deprivation; gene product; heavy metal Pb; heavy metal lead; hippocampal; in vitro Model; in vivo; inhibitor; inhibitor/antagonist; ischemic brain damage; model organism; mutant; necrocytosis; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal survival; neuroprotection; new therapeutics; next generation therapeutics; novel; novel therapeutics; overexpression; oxidation reduction reaction; oxidative DNA damage; oxidative damage; pathway; prevent; preventing; repair; repair endonuclease; repair enzyme; repaired; reperfusion; shRNA; short hairpin RNA; siRNA; small hairpin RNA; social role; stroke; transgenic; treatment strategy",Inducible DNA repair in cerebral ischemia,,36736,BINP,Brain Injury and Neurovascular Pathologies Study Section,,12,295283,
7755842,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS036812-12,,NINDS:389803;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,FARMINGTON,UNITED STATES,NEUROSCIENCES,05,022254226,US,CT,06030,UNIVERSITY OF CONNECTICUT SCH OF MED/DNT,"HEWETT, SANDRA J;",1899502;,5R01NS036812,09/01/1997,12/31/2013,"15-LOX; 15-Lipoxygenase; 15-Lipoxygenase, Reticulocyte Arachidonate; ALOX15; Acquired brain injury; Ammon Horn; Animals; Animals, Wild; Apoplexy; Arachidonate 15-Lipoxygenase; Arachidonate Omega-6 Lipoxygenase; Arachidonate[{..}]oxygen 15-oxidoreductase; Arachidonic Acid 15-Lipoxygenase; Biochemical; Blood leukocyte; Brain; Brain Injuries; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Complement; Complement Proteins; Cornu Ammonis; Data; Development; EAA receptor; Economic Burden; Emotional; Encephalon; Encephalons; Engineering; Engineerings; Excitatory Amino Acid Receptors; Glutamate Receptor; Goals; Grant; Hippocampus; Hippocampus (Brain); INFLM; In Vitro; Inflammation; Inflammatory; Injection of therapeutic agent; Injections; Injury; Ischemic Neuronal Injury; Knowledge; Leukocytes; Link; Lipoxygenase Inhibitors; Literature; Marrow leukocyte; Measures; Mediating; Microinjections; Middle Cerebral Artery Occlusion; Molecular; Morbidity; Morbidity - disease rate; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nervous System, Brain; Neuronal Injury; Occlusion, Middle Cerebral Artery; Oxidative Stress; Pathway interactions; Predisposition; Public Health; Receptors, Excitatory Amino Acid; Relative; Relative (related person); Research; Reticuloendothelial System, Leukocytes; Staging; Stroke; Susceptibility; Therapeutic; Therapeutic Studies; Therapy Research; Time; Vascular Accident, Brain; White Blood Cells; White Cell; Wild Animals; Wild Type Mouse; base; brain attack; brain damage; brain lesion (from injury); cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; excitatory aminoacid receptor; excitotoxicity; hippocampal; in vivo; inhibitor; inhibitor/antagonist; mutant; neuron injury; new therapeutic target; novel; pathway; prevent; preventing; public health medicine (field); public health relevance; stroke; white blood cell; white blood corpuscle",Excitotoxicity and Inflammation, PROJECT NARRATIVE Morbidity associated with stroke remains a huge emotional and economic burden due in large part to a void in treatment options to protect against secondary injury. It is our contention that successful completion of this proposal will advance and refine our knowledge about an important new therapeutic target (L-12/15 LO) that complements other ongoing efforts to reduce injury following cerebral ischemic insult.,36812,NOMD,Neural Oxidative Metabolism and Death Study Section,,12,389803,
7765538,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS037313-11,,NINDS:435416;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,ANESTHESIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"FADEN, ALAN IRA;",1873011;,5R01NS037313,02/03/1999,01/31/2014,"Active Oxygen; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Attenuated; Body Tissues; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; Cell model; CellLine; Cells; Cellular model; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Enzymes; Event; Hortega cell; INFLM; Idiopathic Parkinson Disease; In Vitro; Incidence; Inflammation; Inflammatory; Injury; Intracellular Communication and Signaling; Investigation; Knockout Mice; Laboratories; Lewy Body Parkinson Disease; Mediating; Mice, Knock-out; Mice, Knockout; Microglia; Modeling; Multienzyme Complexes; NADPH Oxidase; NADPH Oxidase 1; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neurologic Dysfunctions; Neuron Degeneration; Neurons; Null Mouse; Oxygen Radicals; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients with traumatic brain injury; Pilot Projects; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Pro-Oxidants; Production; Proteins; Reactive Oxygen Species; Receptor Protein; Relative; Relative (related person); Role; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Syndrome; TBI Patients; Tissues; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Work; attenuation; biological signal transduction; cultured cell line; dementia of the Alzheimer type; disease/disorder; enzyme complex; functional outcomes; gene product; gitter cell; improved; knockout animal; mesoglia; microglial cell; microgliocyte; neural degeneration; neurodegeneration; neurological dysfunction; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuronal toxicity; neurotoxicity; novel therapeutic intervention; perivascular glial cell; pilot study; prevent; preventing; primary degenerative dementia; public health relevance; receptor; senile dementia of the Alzheimer type; social role; traumatic brain damage",mGluR5 inhibits microglial activation and neuronal cell death after TBI," There are 1 million incidences of traumatic brain injury (TBI) per year nationally. Patients with TBI demonstrate evidence of prolonged microglial activation that lasts at least 3 weeks post-injury. The proposed work, in which we will investigate the neuroprotective effects of microglial and neuronal mGluR5, will provide initial investigation to a novel therapeutic approach for TBI.",37313,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,11,435416,
7763200,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS037462-10,,NINDS:534728;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"BELLIVEAU, JOHN W;",1871118;,5R01NS037462,07/23/1998,01/31/2014,"Algorithms; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Analysis, Data; Apoplexy; Area; Attention; Behavior; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Brain imaging; Causality; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Clinical; Cognition; Collection; Complex; Cortical Synchronization; Data; Data Analyses; Data Sources; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Development; Disease; Disorder; EEG; Electroencephalography; Encephalon; Encephalons; Equation; Etiology; Frequencies (time pattern); Frequency; Functional Magnetic Resonance Imaging; Goals; Head; Human; Human, General; Image; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; In element; Indium; Investigation; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Magnetoencephalography; Man (Taxonomy); Man, Modern; Maps; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Modeling; Msec; NMR Imaging; NMR Tomography; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear Magnetic Resonance Imaging; Pattern; Perception; Phase; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; ROC Analysis; Research; Resolution; Sampling; Science of neurophysiology; Series; Site; Source; Sources, Data; Stroke; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Testing; Time; Variant; Variation; Vascular Accident, Brain; Visual; Visual Cortex; Visual System; Visual attention; Visual system structure; Weight; Work; Zeugmatography; base; brain attack; brain behavior; brain visualization; cerebral vascular accident; data acquisition; dementia of the Alzheimer type; developmental disease/disorder; developmental disorder; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; fMRI; image evaluation; imaging; imaging modality; improved; innovate; innovation; innovative; millimeter; millisecond; neural; neural mechanism; neural model; neuroimaging; neuromechanism; neuronal; neurophysiology; novel; primary degenerative dementia; programs; public health relevance; relating to nervous system; research study; response; senile dementia of the Alzheimer type; simulation; spatiotemporal; stroke; tumors in the brain; visual cortical; visual motor; visual process; visual processing; visuomotor",Spatiotemporal Imaging of Human Visual System Processing, PROJECT NARRATIVE We will develop spatiotemporal brain imaging methods that will enable non-invasive studies of the human visual system at a higher resolution than previously achieved. These techniques may also help studies on various clinical abnormalities and developmental disorders.,37462,BMIT,Biomedical Imaging Technology Study Section,,10,534728,
7761704,R01,NS,5,,02/01/2010,01/31/2011,PA-06-544,5R01NS038261-11,,NINDS:294308;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,GALVESTON,UNITED STATES,NEUROSCIENCES,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"NEUGEBAUER, VOLKER ;",1871306;,5R01NS038261,07/01/1999,01/31/2012,"Abbreviations; Action Potentials; Address; Affect; Affective; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Area; Arthritis; Arthritis, Experimental; Arts; Aves; Avian; Behavior; Behavioral; Bicuculline; Birds; Brain; Carrageenan; Carrageenin; Cell Nucleus; Cells; Cellular Membrane; Cerebrospinal Fluid; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Common Rat Strains; Control Animal; Control Groups; Data; Decision Making; Disinhibition; Disturbance in cognition; Drugs; Electric Stimulation; Electrical Stimulation; Electrophysiology; Electrophysiology (science); Emotional; Emotions; Encephalon; Encephalons; Experimental Arthritis; Figs; Figs - dietary; Food; Funding; GABA Antagonists; GABA Receptor Antagonists; Gambling; Gamblings; Goals; Hindlimb; Human; Human, General; Impaired cognition; Impairment; In Vitro; In element; Indium; Injection of therapeutic agent; Injections; Injections, Intra-Articular; Intervention; Intervention Strategies; Intra-Articular Injections; Intraarticular Injections; Investigators; Iowa; Kaolin; Knee; Knee joint; Lateral; Literature; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medial; Mediating; Medication; Microdialysis; Modeling; NIH; NMDA receptor antagonist; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Nociception; Nucleus; Outcome Measure; Pain; Pain Control; Pain Therapy; Pain management; Painful; Patients; Pattern; Persistent pain; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Prefrontal Cortex; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Receptor Protein; Reflex; Reflex action; Relative; Relative (related person); Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Rewards; Risk; Risk Behaviors; Risky Behavior; Role; Saline; Saline Solution; Slice; Source; Spinal; Structure; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Time; Translational Research; Translational Research Enterprise; Translational Science; Transmission; Ultrasonic; Ultrasonics; United States National Institutes of Health; Withdrawal; Work; amygdaloid nuclear complex; arthritic; at risk behavior; awake; base; behavior test; behavioral disinhibition; behavioral test; clinical relevance; clinically relevant; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; drug/agent; experiment; experimental research; experimental study; extracellular; gamma-Aminobutyric Acid Antagonists; high risk; high risk behavior; improved; in vivo; indexing; innovate; innovation; innovative; interdisciplinary approach; intervention effect; interventional strategy; neural mechanism; neurobiological mechanism; neuromechanism; neuronal; neuronal excitability; nociceptive; novel; pain behavior; patch clamp; perceptual stimulus; physicochemical phenomena related to the senses; postsynaptic; preference; presynaptic; programs; receptor; research study; response; sensory stimulus; social role; spinal fluid; translation research enterprise; transmission process; vocalization","Pain, Nociception, and the Amygdal",,38261,SCS,Somatosensory and Chemosensory Systems Study Section,,11,294308,
7752481,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS038752-09,,NINDS:355678;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STORRS-MANSFIELD,UNITED STATES,PHYSIOLOGY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"DE BLAS, ANGEL L;",1866712;,5R01NS038752,04/01/2000,01/31/2011,"Affect; Ammon Horn; Antibodies; Assay; Axon; Bioassay; Biologic Assays; Biological Assay; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Common Rat Strains; Complex; Connector Neuron; Cornu Ammonis; Data; Development; Electron Microscopy; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Exocytosis; External Domain; Extracellular Domain; Family; Family member; Figs; Figs - dietary; GABA-A Receptor; GRIP1; Glutamates; Grant; Gray; Gray unit of radiation dose; Heterogeneity; Hippocampus; Hippocampus (Brain); Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Knowledge; L-Glutamate; Link; Mammals, Rats; Mass Spectrum; Mass Spectrum Analysis; Mental disorders; Mental health disorders; Methods and Techniques; Methods, Other; Molecular; NCOA2; NCOA2 gene; Names; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neurons; Photometry/Spectrum Analysis, Mass; Play; Proteins; Psychiatric Disease; Psychiatric Disorder; Pyramidal neuron; RIP; RIP Protein Kinase; RIPK1; RIPK1 protein, human; RNA Splicing; RNA, Small Interfering; Rat; Rattus; Receptor Protein; Receptor-Interacting Protein; Receptor-Interacting Serine/Threonine Kinase 1; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; Role; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Splicing; Structure; Subcellular Fractions; Synapses; Synaptic; Synaptic Vesicles; Synaptic plasticity; TIF2; Techniques; Testing; Time; Two Hybrid; Unspecified Mental Disorder; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; biological signal transduction; density; epilepsia; epileptiform; epileptogenic; gene product; gephyrin; hippocampal; hippocampal pyramidal neuron; human RIPK1 protein; immunocytochemistry; innervation; light microscopy; member; mental illness; nerve supply; neuronal; novel; postsynaptic; presynaptic; psychological disorder; receptor; siRNA; social role; synapse function; synaptic function; trafficking; yeast two hybrid system",GABAA Receptor-Interacting Proteins,,38752,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,9,355678,
7761726,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS038937-08,,NINDS:296998;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AURORA,UNITED STATES,PHYSIOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"RIBERA, ANGELES B;",1908250;,5R01NS038937,07/01/2000,01/31/2011,"Accounting; Affect; Afferent Neurons; Axon; Brachydanio rerio; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cells; Cellular Migration; Code; Coding System; Communities; Danio rerio; Data; Defect; Development; Dorsal Root Ganglia; Duplicate Genes; Embryo; Embryonic; Embryonic Nervous System; Event; Ganglia, Spinal; Gated Ion Channel; GeneHomolog; Genes; Genes, Duplicate; Genetic; Goals; Guidelines; History; Homolog; Homologous Gene; Homologue; Image; Immigrations; In-Migration; Intracellular Communication and Signaling; Investigators; Ion Channels, Sodium; Life; Mammalia; Mammals; Mammals, General; Mediating; Medulla Spinalis; Methods; Modeling; Molecular Genetic; Molecular Genetics; Morphology; Motility; Motility, Cellular; Motor Cell; Motor Neurons; Multigene Family; Muscle; Muscle Tissue; NRVS-SYS; Na element; Names; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neural Crest; Neural Crest Cell; Neurocyte; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurons; Neurons, Afferent; Neurons, Sensory; Nomenclature; Pathway interactions; Pattern; Peripheral; Phenotype; Phylogeny; Physiologic; Physiological; Play; Population; Programs (PT); Programs [Publication Type]; Proteins; Recording of previous events; Research; Research Personnel; Researchers; Role; Secondary to; Sensory; Sensory Cell Afferent Neuron; Signal Transduction; Signal Transduction Systems; Signaling; Sodium; Sodium Channel; Spinal Cord; Spinal Ganglia; Staging; System; System, LOINC Axis 4; Testing; Time; Translations; Transplantation; V (voltage); Zebra Danio; Zebra Fish; Zebrafish; biological signal transduction; cell motility; cell type; design; designing; dorsal root ganglion; experiment; experimental research; experimental study; gene product; imaging; in vivo; knock-down; migration; motoneuron; motor neuron development; mutant; nervous system development; neuron development; neuronal; neuronal excitability; pathway; postnatal; programs; research study; social role; teleost; transplant; voltage",Neuronal Excitability in Wild Type and Mutant Zebrafish,,38937,ZRG1,Special Emphasis Panel,,8,296998,
7751291,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS039050-10,,NINDS:324845;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,ANATOMY/CELL BIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"ERZURUMLU, REHA S;",1884166;,5R01NS039050,04/01/2000,12/31/2013,"21+ years old; 3,5 cyclic AMP synthetase; ATP pyrophosphate-lyase (cyclizing); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adult; Area; Axon; Axon Terminals; Biological Models; Brain; Brain Stem; Brainstem; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Central Nervous System; Data; Defect; Dendrites; Development; Elements; Encephalon; Encephalons; Face; Funding; Gene Deletion; Genes; Grant; Human, Adult; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Laboratories; Lateral; Learning; Lesion; Literature; Mammals, Mice; Mammals, Rodents; Maps; Mediating; Memory; Mice; Mice, Knock-out; Mice, Knockout; Model System; Modeling; Models, Biologic; Molecular; Molecular Genetic; Molecular Genetics; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NR1; NR1 gene; NRVS-SYS; Neocortex; Neonatal; Nerve Endings, Presynaptic; Nervous; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Development; Neuraxis; Neurologic Body System; Neurologic Organ System; Neurosciences; Nucleus; Null Mouse; Pathway interactions; Pattern; Pattern Formation; Peripheral Nerves; Play; Presynaptic Terminals; Process; Receptor Signaling; Receptors, N-Methylaspartate; Rodent; Rodentia; Rodentias; Role; Sensory; Sensory Deprivation; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Somatosensory Cortex; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Testing; Thalamic structure; Thalamus; Time; Vibrissae; Whiskers; adenylcyclase; adult animal; adult human (21+); barrel cortex; base; biological signal transduction; body map; critical period; excitatory neuron; excitotoxicity; experiment; experimental research; experimental study; facial; gene deletion mutation; homotypical cortex; interest; isocortex; knock-down; mature animal; mouse model; neopallium; neural; neural circuit; neural circuitry; neural patterning; neurodevelopment; pathway; postnatal; postsynaptic; presynaptic; public health relevance; receptor function; receptor-mediated signaling; relating to nervous system; research study; social role; somatosensory; somesthetic sensory cortex; thalamic; tool",Somatosensory Cortical Development and Plasticity," Narrative: N-methyl D Aspartate (NMDA) receptors (NMDARs) play a major role in development of neural connections and their plasticity, learning and memory, as well as during excitotoxicity in pathological states of the mature nervous system. In this proposal we shall test the role of NMDARs in the development and plasticity of somatosensory neural circuits by examining neural defects in NMDAR-deficient mouse models.",39050,SCS,Somatosensory and Chemosensory Systems Study Section,,10,324845,
7777246,R01,NS,5,,02/01/2010,11/30/2010,,5R01NS039355-10,,NINDS:335250;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,PHYSIOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"ZHANG, JI-FANG ;",2095483;,5R01NS039355,12/01/1999,11/30/2010,"ATP-protein phosphotransferase; Adaptor Protein; Adaptor Signaling Protein; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Axon; Binding; Binding (Molecular Function); Biochemical; Biochemistry; Brain; Calcium Channel; Calcium Channel Antagonist Receptor; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cellular biology; Chemistry, Biological; Complex; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dendrites; Dephosphorylation; Dolphins; Dolphins - mammal; EC 2.7; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Family; Gene Action Regulation; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Goals; Grant; Image; Integral Membrane Protein; Intracellular Communication and Signaling; Intracellular Second Messengers; Intrinsic Membrane Protein; Investigators; Ion Channels, Calcium; Kinases; Learning; Light; Link; Membrane; Memory; Molecular; Molecular Interaction; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System Physiology; Nervous System, Brain; Neural Cell; Neural Development; Neurocyte; Neurologic Disorders; Neurologic function; Neurological Disorders; Neurological function; Neurons; Neurophysiology / Electrophysiology; Peptide Biosynthesis, Ribosomal; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Photoradiation; Physiologic; Physiological; Play; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Protein Binding; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Dephosphorylation; Protein Kinase; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Synthesis, Ribosomal; Protein phosphatase; Proteins; RNA-Binding Proteins; Receptors, Calcium Channel Blocker; Receptors, N-Methylaspartate; Regulation; Research Personnel; Researchers; Role; Screening procedure; Second Messenger Systems; Second Messengers; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Subcellular Process; Synaptic plasticity; Testing; Transmembrane Protein; Transphosphorylases; Two Hybrid; V (voltage); VDCC; Voltage-Dependent Calcium Channels; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; biological signal transduction; cell biology; dementia of the Alzheimer type; design; designing; experiment; experimental research; experimental study; gene product; glycogen synthase a kinase; hydroxyalkyl protein kinase; imaging; inhibitor; inhibitor/antagonist; membrane structure; nervous system disorder; nervous system function; neurodevelopment; neurological disease; neuronal; neurotransmitter release; novel; phosphorylase b kinase kinase; primary degenerative dementia; programs; protein protein interaction; protein synthesis; research study; screening; screenings; second messenger; senile dementia of the Alzheimer type; social role; voltage; voltage gated channel; yeast two hybrid system",Specificity of calcium channels in neuronal signaling,,39355,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,10,335250,
7760079,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS039444-09,,NINDS:285781;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,ANATOMY/CELL BIOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"WEINBERG, RICHARD J;",1884156;,5R01NS039444,10/01/1999,01/31/2011,"Actin Filaments; Actins; Address; Ammon Horn; Architecture; Biochemical; Brain; Cell Communication and Signaling; Cell Signaling; Cellular Matrix; Communication; Cornu Ammonis; Cytoskeletal Proteins; Cytoskeletal System; Cytoskeleton; Development; Disease; Disorder; Dysfunction; Encephalon; Encephalons; Engineering / Architecture; Epilepsy; Epileptic Seizures; Epileptics; Functional disorder; Goals; Hippocampus; Hippocampus (Brain); Individual; Intracellular Communication and Signaling; Knowledge; Learning; Mammals, Rodents; Maps; Mediating; Memory; Mental disorders; Mental health disorders; Microfilaments; Molecular; Morphology; Myofilaments; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurological; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Physiopathology; Play; Postsynaptic Membrane; Process; Proteins; Psychiatric Disease; Psychiatric Disorder; Receptors, N-Methylaspartate; Receptors, Neurohumor; Research; Research Proposals; Resolution; Rodent; Rodentia; Rodentias; Role; Seizure Disorder; Shapes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Column; Spine; Structure; Synapses; Synaptic; Time; Unspecified Mental Disorder; Vertebral column; Work; backbone; biological signal transduction; density; developmental disease/disorder; developmental disorder; disease/disorder; electron tomography; epilepsia; epileptiform; epileptogenic; gene product; hippocampal; improved; insight; intracellular skeleton; mental illness; neuronal; neuropsychiatric; neuropsychiatry; pathophysiology; postsynaptic; psychological disorder; social role",Supramolecular Organization of the Postsynaptic Density,,39444,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,9,285781,
7752796,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS039456-11,,NINDS:353031;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROSCIENCES,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KNIERIM, JAMES J;",1929315;,5R01NS039456,12/01/1999,01/31/2013,"Accounting; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Amnesia; Amnesia-Memory Loss; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Area; Binding; Binding (Molecular Function); Biological Models; Biological Neural Networks; Brain; Brain Diseases; Brain Disorders; Brain region; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cognitive; Common Rat Strains; Complex; Conscious; Consciousness; Cornu Ammonis; Cues; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dentate Fascia; Dentate Gyrus; Disease; Disorder; Dissociation; Distal; Dorsal; Electrodes; Encephalon; Encephalon Diseases; Encephalons; Entorhinal Area; Entorhinal Cortex; Epilepsy; Epileptic Seizures; Epileptics; Episodic memory; Episodic memory, function; Event; Fascia Dentata; Gyrus Dentatus; Head; Hippocampal Formation; Hippocampus; Hippocampus (Brain); Human; Human, General; IT Systems; Individual; Information Systems; Information Technology Systems; Injury; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Knowledge; Lateral; Lesion; Life; Location; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Memory; Memory Loss; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Molecular Interaction; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pattern; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Rat; Rattus; Recurrence; Recurrent; Relative; Relative (related person); Resolution; Role; Rotation; Seizure Disorder; Series; Services; Site; Stream; Stroke; Structure; Structure of dentate gyrus; Structure of entorhinal cortex; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; Syndrome; System; System, LOINC Axis 4; Systems, Data; Techniques; Testing; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Vascular Accident, Brain; Work; base; brain attack; cerebral vascular accident; cognitive neuroscience; computer-based representation; dementia of the Alzheimer type; density; dentate gyrus; disease/disorder; entorhinal cortex; epilepsia; epileptiform; epileptogenic; experience; experiment; experimental research; experimental study; frame-based representation; hippocampal; information organization; information processing; insight; knowledge representation; memory retrieval; model organism; neural; neural network; neuronal; parallel processing; primary degenerative dementia; relating to nervous system; research study; response; senile dementia of the Alzheimer type; social role; stroke; surgery; traumatic brain damage; treatment strategy",Multi-Site Analysis of Hippocampal Neuronal Ensembles," Project Narrative Profound memory loss is a hallmark of such degenerative brain disorders as Alzheimer's Disease, which originates in an area called the entorhinal cortex, progresses into the hippocampus, and eventually progresses throughout the brain's cortical regions. The experiments in this proposal will address fundamental issues regarding the nature of information processing and functions in the entorhinal cortex and hippocampus, generating insight into how these brain regions work normally and how they may go awry when the regions are damaged by Alzheimer's epilepsy, stroke, or traumatic injury.",39456,ZRG1,Special Emphasis Panel,,11,353031,
7760577,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS039951-10,,NINDS:409424;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,TUCSON,UNITED STATES,OTHER BASIC SCIENCES,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"HANDA, ROBERT J;",1893370;,5R01NS039951,02/01/2009,01/31/2014,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 17beta-Hydroxy-5alpha-Androstan-3-One; 21+ years old; 25-HC 7alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7alpha-hydroxylase; 3 beta-hydroxysteroid 7-alpha-hydroxylase; 5 alpha-Dihydrotestosterone; 5 alpha-androstane 3 beta,17 beta-diol 7 alpha-hydroxylase; 5-alpha-DHT; 5alpha-androstane-3beta,17beta-diol 7-alpha-hydroxylase; ACTH; ACTH (1-39); ACTH-Releasing Factor; ADRGND; Address; Adenohypophysis; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Adult; Agonist; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-; Androstanes; Androstanolone; Animal Model; Animal Models and Related Studies; Animals; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Antidiuretic Hormone; Antidiuretic Hormones; Aquadiol; Area; Assay; Autoregulation; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Brain; Brain Stem; Brain region; Brainstem; CHIP assay; CRF-41; CRH; CYP7B1; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Cells; ChIP (chromatin immunoprecipitation); Chemotherapy-Hormones/Steroids; Common Rat Strains; Corticoliberin; Corticosterone; Corticotropin; Corticotropin (1-39); Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; DHEA 7-alpha-hydroxylase; DHT; Data; Dehydrogenases; Delta4-androsten-17beta-ol-3-one; Dihydrotestosterone; Dimenformon; Diogyn; Diogynets; ERalpha; ERbeta; Encephalon; Encephalons; Endocrine Gland Secretion; Enzymes; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol Receptor alpha; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exhibits; F-SRC-1; FOS gene; Feedback; Female; Future; G0S7; GRIP1; Gene Transcription; Genes; Genes, Reporter; Genetic Transcription; Genetics, in situ Hybridization; Glean; Glucocorticoid Receptor; Glucocorticoids; Glycols; Goals; Gonadal Steroid Hormones; Histone Acetylation; Homeostasis; Hormonal; Hormones; Human; Human, Adult; Human, General; Hydroxysteroid Dehydrogenases; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; In Situ Hybridization; Infusion; Infusion procedures; Intermediary Metabolism; Knock-out; Knockout; Knockout Mice; Ligand Binding; Ligands; Location; METBL; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Messenger RNA; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Molecular Interaction; Murine; Mus; Mutagenesis, Site-Directed; NCOA1; NCOA2; NCOA2 gene; NCoA-1; NCoA-1 protein; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, Pituitary; Neural Cell; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neuropeptides; Neurosecretory Systems; Nucleus; Null Mouse; OXT; Ocytocin; Output; Ovocyclin; Ovocylin; Oxidoreductase; Oxytocin; Oxytocin Receptor; Paraventricular Hypothalamic Nucleus; Paraventricular Nucleus; Pars Anterior Pituitary Gland; Pathway interactions; Physiological Homeostasis; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Pituitary-Adrenal System; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Progynon; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protooncogene FOS; Publishing; RNA Expression; RNA, Messenger; Rat; Rattus; Receptors, Steroid; Recombinant Oxytocin; Recruitment Activity; Reductases; Regulation; Regulatory Element; RegulatoryElement; Reporter; Reporter Genes; Role; SRC-1; SRC1; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Son; Stanolone; Steroid Compound; Steroid Receptors; Steroids; Stress; Structure of paraventricular nucleus; TIF2; Targeted DNA Modification; Targeted Modification; Testing; Testosterone; Therapeutic Androgen; Therapeutic Androstanolone; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Glucocorticoid; Therapeutic Hormone; Therapeutic Testosterone; Trans-Testosterone; Transcription; Transcription, Genetic; Transgenic Mice; Vasopressins; adult human (21+); androstane compound; beta-Hypophamine; biological adaptation to stress; c fos; c-fos Gene; c-fos Proto-Oncogenes; chromatin immunoprecipitation; chromatin modification; corticotropin releasing hormone; cultured cell line; cytochrome P-450 CYP7B1; dehydroepiandrosterone 7-alpha-hydroxylase; gender difference; gonadal steroids; hypothalamic; in situ Hybridization Staining Method; interest; mRNA; mRNA Expression; male; model organism; mouse model; neural circuit; neural circuitry; neurobiological mechanism; neuronal; novel; nuclear receptor coactivator 1; oxysterol 7-alpha-hydroxylase; paraventricular nucleus; pathway; pituitary adrenal axis; prevent; preventing; psychological stressor; public health relevance; reaction; crisis; recombinase; recruit; reproductive; reproductive hormone; response; sex; sex steroid; sexual dimorphism (noncellular); social role; steroid receptor coactivator 1; stress response; stress; reaction; suprarenal gland; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis, NARRATIVE Sex differences exist in the hormonal response of animals to physical and psychological stressors. These sex differences arise as a result of the actions of estrogen and androgen acting upon neural circuits within the hypothalamus. In this application we will test the hypothesis that the actions of testosterone act to inhibit neuroendocrine responses to stress through metabolism to 3¨-Diol and subsequent binding to estrogen receptor beta found in oxytocin neurons of the hypothalamus.,39951,ZRG1,Special Emphasis Panel,,10,409424,
7743995,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS040471-10,,NINDS:290046;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","WINDEBANK, ANTHONY JOHN;",1870044;,5R01NS040471,06/01/2000,12/31/2010,"(SP-4-2)-Diamminedichloroplatinum; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex; 1,2-diaminocyclohexane platinum oxalate; 1,2-diamminocyclohexane(trans-1)oxolatoplatinum(II); 1-OHP; 2',3'-Dideoxycytidine; Acute; Adenoviral Vector; Adenovirus Vector; Adverse effects; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; CBDCA; CCND1 Protein; CDDP; Cancer Treatment; Carboplatin; Carboplatino; Carcinogen-DNA Adducts; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Cycle; Cell Death; Cell Death, Programmed; Cell Division Cycle; Cessation of life; Chronic; Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical; Cyclin D1; Cysplatyna; Cysteine; Cytidine, 2',3'-dideoxy-; DDP; DNA; DNA Adducts; DNA Binding; DNA Binding Interaction; DNA Damage; DNA Injury; DNA Replication; DNA Synthesis; DNA Synthesis Inhibitors; DNA biosynthesis; DNA lesion; DNA, Mitochondrial; Death; Deoxyribonucleic Acid; Diaminocyclohexane Oxalatoplatinum; Dichlorodiammineplatinum; Dideoxycytidine; Dorsal Root Ganglia; Dose; Dose-Limiting; Drugs; EC 6.3.2.2; Exhibits; Exposure to; G1/S-Specific Cyclin D1; GFAC; Gamma-Glutamylcysteine Synthetase; Gamma-Glutamylcysteinyl Synthetase; Ganglia, Spinal; Gene Transcription; Genetic Transcription; Glutamate-Cysteine Ligase; Glutamylcysteine Synthetase; Glutathione; Glutathione Synthetase; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Half-Cystine; Hivid; Hour; In Vitro; Inhibitors, DNA Synthesis; Investigators; Knockout Mice; L-Cysteine; L-Glutamate[{..}]L-cysteine gamma-ligase (ADP-forming); L-OHP cpd; Lead; Ligase; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Mammals, Mice; Mammals, Rodents; Measures; Mediating; Medication; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Mitochondrial DNA; Molecular Interaction; Murine; Mus; Nerve Cells; Nerve Growth Factors; Nerve Unit; Neural Cell; Neurocyte; Neuronal Injury; Neuronotrophic Factors; Neurons; Neuropathy; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Nuclear; Null Mouse; Oxalatoplatin; Oxalatoplatinum; PCR; PRAD1 Protein; Pathway interactions; Pb element; Peripheral Sensory Neuropathy; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Pigment Epithelium; Platinum; Platinum Agents; Platinum Black; Platinum Compounds; Platinum Compounds, Inorganic; Platinum Diamminodichloride; Platinum adduct; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Polymerase Chain Reaction; Programs (PT); Programs [Publication Type]; Proto-Oncogene Proteins c-bcl-1; Pt element; R-DNA; RNA Expression; RNA chemical synthesis; RNA synthesis; RT-PCR; RTPCR; Research Personnel; Researchers; Respiratory Chain; Reverse Transcriptase Polymerase Chain Reaction; Rodent; Rodentia; Rodentias; Spinal Ganglia; Synthetases; Testing; Therapeutic; Time; Transcription; Transcription, Genetic; Treatment Side Effects; Viral; Viral Vector; Zalcitabine; [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum; adeno vector; adenovector; anticancer therapy; base; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; c-bcl-1 Proteins; cancer therapy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diammine(cyclobutanedicarboxylato)platinum II; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II); clinical relevance; clinically relevant; cyclin D; ddC; ddC (Antiviral); dorsal root ganglion; drug withdrawal; drug/agent; gamma-Glutamyl-Cysteine Synthetase; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gamma-L-Glutamyl-L-cysteine[{..}]glycine ligase (ADP-forming); glutathione synthase; heavy metal Pb; heavy metal lead; in vivo; mitochondrial; mitochondrial genome; model organism; mtDNA; necrocytosis; neuron cell death; neuron injury; neuron loss; neuronal; neuronal cell death; neuronal loss; neuropathic; neuroprotection; neurotoxic; new approaches; novel; novel approaches; novel strategies; novel strategy; oxalato (1R,2R-cyclohexanediamine)platinum(II); oxalato (trans-l-1,2-diaminocyclohexane)platinum(II); oxalato-(1,2-cyclohexanediamine)platinum II; oxaliplatin; oxaliplatine; pathway; platinum(II)-1,2-cyclohexanediamine oxalate; platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2); prevent; preventing; programs; repair; repaired; reverse transcriptase PCR; sensory neuropathy; side effect; therapy adverse effect; trans-l DACH oxalatoplatinum; trans-l diaminocyclohexane oxalatoplatinum; treatment adverse effect",Mechanisms of Neuronal Death and Neuroprotection,,40471,ZRG1,Special Emphasis Panel,,10,290046,
7768379,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS040944-10,,NINDS:409922;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DALLAS,UNITED STATES,BIOCHEMISTRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"RIZO-REY, JOSE ;",1884146;,5R01NS040944,01/25/2001,01/31/2014,"1,2-diacylglycerol; Affect; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Function; Biological Process; Brain; C 1 Esterase; C-terminal; C1 Domain; C1 Esterase; C1 s; C1s; C2 Domain; Cell membrane; Cells; Central Nervous System; Characteristics; Collaborations; Complement; Complement 1 Esterase; Complement 1s; Complement Proteins; Complement component C1s; Complex; Cryo-electron Microscopy; Cryoelectron Microscopy; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytoplasmic Membrane; DAG; DAG Binding Domain; DAG/PE-Binding Domain; Data; Development; Diacylglycerol Binding Domain; Diacylglycerols; Diglycerides; Disease; Disorder; Docking; Drugs; Electron Cryomicroscopy; Encephalon; Encephalons; Exhibits; Exocytosis; Fluorescence Spectroscopy; GeneHomolog; Genetic; Goals; Grant; Homolog; Homologous Gene; Homologue; In Vitro; Intracellular Membranes; Isoforms; Knowledge; Laboratories; Left; Light; Lipids; Mediating; Medication; Membrane; Membrane Fusion; Membrane Protein Traffic; Membrane Traffic; Methods; Molecular; Molecular Interaction; NMR Spectroscopy; NSF attachment protein receptor; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neural Transmission; Neuraxis; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology - biologic function; Peptide Domain; Pharmaceutic Preparations; Pharmaceutical Preparations; Phorbol Ester Binding Domain; Phosphatides; Phospholipids; Photoradiation; Plasma Membrane; Play; Process; Property; Property, LOINC Axis 2; Protein Domains; Protein Isoforms; Protein Kinase C Conserved Region 1 Domain; Proteins; Reaction; Regulation; Research; Resolution; Role; SNAP receptor; SNARE; Single Crystal Diffraction; Spectroscopy, Fluorescence; Spectroscopy, NMR; Structure; Synaptic Transmission; Synaptic Vesicles; Tertiary Protein Structure; Testing; Time; VESCL; Vesicle; Work; X Ray Crystallographies; X-Ray Crystallography; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; base; controlled release; cryoEM; diacylglycerol; diglyceride; disease/disorder; drug/agent; experiment; experimental research; experimental study; gene product; in vivo; information processing; insight; intervention development; macromolecular assembly; membrane structure; nervous system disorder; neural function; neurological disease; neuronal; neurotransmitter release; new approaches; novel approaches; novel strategies; novel strategy; nuclear magnetic resonance spectroscopy; p65 protein; plasmalemma; presynaptic; public health relevance; research study; sensor; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; synaptic vesicle protein p65; synaptotagmin; synaptotagmin 1; synaptotagmin I; syt (synaptotagmin); therapy development; treatment development",Synaptotagmin and C2-domains: structure and function," The research proposed in this application will yield key insights into fundamental molecular mechanisms that underlie synaptic transmission and some forms of information processing in the brain. This knowledge is critical to understand how the brain and the nervous system in general function. Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders.",40944,ZRG1,Special Emphasis Panel,,10,409922,
7750496,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS041319-09,,NINDS:325516;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DETROIT,UNITED STATES,NEUROLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"SHY, MICHAEL E;",1872526;,5R01NS041319,04/05/2001,12/31/2010,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; Adhesion Molecule; Adhesions; Adult; Age; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Axon; Back; Biopsy; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cell surface; Cells; Charcot Marie Disorder; Charcot Marie Muscular Atrophy; Charcot Marie Tooth Disorder; Charcot Marie Tooth muscular atrophy; Charcot-Marie Disease; Charcot-Marie-Tooth; Charcot-Marie-Tooth Disease; Charcot-Marie-Tooth neuropathy; Cytoplasmic Domain; Cytoplasmic Tail; Data; Development; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dorsum; Evaluation; Family; Genetic Alteration; Genetic Change; Genetic defect; Genotype; Glia; Glial Cells; Glycoproteins; Grant; Human; Human, Adult; Human, General; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; In Vitro; Intracellular Communication and Signaling; Kolliker's reticulum; Macropain; Macroxyproteinase; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Molecular; Multicatalytic Proteinase; Murine; Mus; Mutation; Myelin; Nerve; Nerve Conduction; Nervous; Neural Conduction; Neurilemma Cell; Neurilemmal Cell; Neuroglia; Neuroglial Cells; Neuropathy; Non-neuronal cell; Onset of illness; Pathology; Pathway interactions; Patients; Peripheral; Peripheral Nerves; Peroneal Muscular Atrophy; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteosome; Schwann Cells; Severity of illness; Signal Transduction; Signal Transduction Systems; Signaling; Structural Protein; Structure; Testing; adult human (21+); biological signal transduction; cell adhesion protein; clinical phenotype; disease onset; disease severity; disease/disorder; disorder onset; dysmyelinating; dysmyelination; early onset; extracellular; falls; gain of function; gene product; genome mutation; homologous recombination; in vivo; infancy; infantile; inhibitor; inhibitor/antagonist; late disease onset; late onset disorder; mouse model; multicatalytic endopeptidase complex; mutant; myelination; nerve cement; neuropathic; pathway; protein degradation; response",Early and Late Onset CMT1B,,41319,NDBG,Neurodegeneration and Biology of Glia Study Section,,9,325516,
7760110,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS041497-09,,NINDS:293289;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROSCIENCES,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"BREZINA, VLADIMIR ;",1934841;,5R01NS041497,06/15/2001,01/31/2011,"Address; Animal Behavior; Animal Feed; Animals; Aplysia; Apoplexy; Behavior; Behavior, Animal; Biological Models; Biological Neural Networks; Bite; Brain; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Coupled; Data; Deglutition; Encephalon; Encephalons; Environment; Feeding behaviors; Generations; Goals; Ingestive Behavior; Marines; Math Models; Mediating; Model System; Modeling; Models, Biologic; Motor; Motor output; Movement; NRVS-SYS; Nervous System; Nervous System, Brain; Nervous system structure; Neurologic Body System; Neurologic Organ System; Organ System; Performance; Preparation; Process; Property; Property, LOINC Axis 2; Research; Role; Sampling; Sensory; Stroke; Swallowing; System; System, LOINC Axis 4; Testing; Uncertainty; Vascular Accident, Brain; Work; animal food; body movement; body system; brain attack; central pattern generator; cerebral vascular accident; doubt; experiment; experimental research; experimental study; feeding; feeding-related behaviors; human disease; mathematical model; mathematical modeling; motor control; neural network; neuromotor system; neuromuscular; neuromuscular system; nutrient intake activity; research study; social role; stroke; theories",Functional dynamics of motor control,,41497,SMI,Sensorimotor Integration Study Section,,9,293289,
7754034,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS041548-09,,NINDS:363566;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLLEGE STATION,UNITED STATES,PSYCHOLOGY,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"GRAU, JAMES W;",8016182;,5R01NS041548,04/01/2001,01/31/2011,"Address; Adverse effects; Affect; Ammon Horn; Arts; Assay; Attenuated; BDNF; BDNF Receptor; BDNF/NT-3 Growth Factors Receptor; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Model; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bioassay; Biologic Assays; Biological Assay; Biological Models; Blotting, Western; Body Tissues; Brain; Brain-Derived Neurotrophic Factor; Bruise; Cellular Assay; Chest; Circulatory Collapse; Clinic; Clinical; Common Rat Strains; Communication; Complement; Complement Proteins; Conditioning Therapy; Confocal Microscopy; Contusions; Cornu Ammonis; Coupled; Couples; Coupling; Data; Development; Drug usage; ELISA; Effectiveness; Electric Stimulation; Electrical Stimulation; Encephalon; Encephalons; Environment; Enzyme-Linked Immunosorbent Assay; Equipment; Exercise; Exercise, Physical; Exhibits; Exposure to; Extremities; FES; FPS; FPS-FES Oncogene; Fiber; Fostering; Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene; GP145-TRKB; Gamma Globulin, 7S; Genetics, in situ Hybridization; Goals; Grant; Hindlimb; Hippocampus; Hippocampus (Brain); Human; Human, General; IgG; Immunoglobulin G; In Situ Hybridization; Injury; Instrumental Learning; Intractable Pain; Investigators; Laboratories; Learning; Leg; Life Style Modification; Limb structure; Limbs; Long-Term Potentiation; Loss of Sensation; MGC34632; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Methods and Techniques; Methods, Other; Microscopy, Confocal; Model System; Modeling; Models, Biologic; Myelopathy, Traumatic; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NTRK2; NTRK2 Receptor; National Institute of Neurological Disorders and Stroke; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Neurotrophic Factor, Brain-Derived, Receptor; Neurotrophic Tyrosine Kinase Receptor Type 2; Non-Trunk; Numbness; Oncogene FES; Oncogene, FPS-FES; Operant Conditioning; Operant Conditionings; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pain, Intractable; Palsy; Paralysed; Patients; Pharmacological Treatment; Physical Health Services / Rehabilitation; Physiologic; Physiological; Play; Plegia; Position; Positioning Attribute; Procedures; Programs (PT); Programs [Publication Type]; Proteins; RT-PCR; RTPCR; Rat; Rattus; Receptor, trkB; Receptors, N-Methylaspartate; Recovery; Recovery of Function; Refractory Pain; Regimen; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Relative; Relative (related person); Research; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; Science of neurochemistry; Shapes; Shock; Signal Pathway; Spinal; Spinal Cord; Spinal Cord Plasticity; Spinal Cord Trauma; Spinal Injuries; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stream; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; TRKB; TRKB Tyrosine Kinase; Techniques; Testing; Therapeutic Effect; Thorace; Thoracic; Thorax; Time; Tissues; Training; Translating; Translatings; Treatment Effectiveness; Treatment Side Effects; Western Blotting; Western Blottings; Western Immunoblotting; Work; behavior intervention; behavioral intervention; behavioral pharmacology; circulatory shock; clinical significance; clinically significant; design; designing; drug use; functional recovery; gene product; hippocampal; in situ Hybridization Staining Method; innervation; innovate; innovation; innovative; instrumental conditioning; intractable pain syndrome; language translation; mRNA Expression; nerve supply; neural; neural growth; neural patterning; neurobiological; neurobiological mechanism; neurochemistry; neuronal; neurotrophic factor; neurotrophin; neutrophin; novel; paralysis; paralytic; prevent; preventing; programs; protective effect; protein blotting; rehabilitative; relating to nervous system; response; reverse transcriptase PCR; side effect; social role; spine injury; surgery; therapy adverse effect; treatment adverse effect; trkB(gp145) Protein; vertebral injury",Learning Within the Spinal Cord: Clinical Implications,,41548,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,9,363566,
7760915,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS041962-07,,NINDS:314016;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,PATHOLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"ROTH, KEVIN AARON;",1897184;,5R01NS041962,07/01/2001,01/31/2013,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Adexone; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amplidermis; Anemul mono; Animal Welfare; Antimicotico; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Aquapred; Autophagocytosis; Auxiloson; Awareness; Awarenesses; Azona; Baycuten; Baycuten N; Bibliography; Brain; Brain Hypoxia-Ischemia; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Causality; Cell Death; Cell Death, Programmed; Cell Lineage; Cell Transformation, Neoplastic; Cell-Death Protease; Cells; Cerebral Palsy; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Childhood; Corson; Cortidexason; Cortisumman; Country; Data; Death; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Deronil; Desamethasone; Desameton; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Ecological impact; Encephalon; Encephalons; Engraftment; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Etiology; Family; Family member; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Foundations; Gammacorten; Gene Combinations; Gene Transcription; Genes; Genes, p53; Genetic Transcription; Genotoxic Stress; Glucocorticoids; Goals; Grant; Hexadecadrol; Hexadrol; Human; Human, General; Hypoxia; Hypoxia-Ischemia, Brain; Hypoxic; Hypoxic-Ischemic Brain Injury; IACUC; ICE-like protease; IRBs; Idiopathic Parkinson Disease; Impact, Environmental; In Vitro; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Investigators; Ischemic-Hypoxic Encephalopathy; Lead; Lewy Body Parkinson Disease; Link; Lokalison-F; Loverine; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Medulla Spinalis; Mental disorders; Mental health disorders; Methylfluorprednisolone; Mice; Millicorten; Mitochondria; Modeling; Molecular; Multiple Sclerosis; Murine; Mus; Myelopathy, Traumatic; Mymethasone; NRVS-SYS; Neonatal; Neoplastic Cell Transformation; Nerve Degeneration; Nervous; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neural Stem Cell; Neurologic; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological; Neurological Disorders; Neuron Degeneration; Ocasa; Orgadrone; Oxygen Deficiency; P53; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Pb element; Perinatal; Perinatal Brain Injury; Perinatal brain damage; Physiologic; Physiological; Play; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Premature Birth; Preterm Birth; Primary Parkinsonism; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Psychiatric Disease; Psychiatric Disorder; Puma; Puma (Felidae); RNA Expression; Recovery of Function; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Sclerosis, Disseminated; Series; Spersadex; Spersadox; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stimulus; Stress; Stress, Genotoxic; Stroke; TP53; TP53 gene; TRP53; Testing; Therapeutic Agents; Therapeutic Glucocorticoid; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Transplantation; Tumor Protein p53 Gene; Unspecified Mental Disorder; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; Vertebrate Animals; Vertebrates; Visumetazone; abstracting; auricularum; autophagy; base; brain attack; caspase; cerebral vascular accident; cystein protease; cystein proteinase; cysteine endopeptidase; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; expiration; functional recovery; gene product; heavy metal Pb; heavy metal lead; human subject; hypoxia ischemia; in vivo; insight; insular sclerosis; malformation; member; mental illness; mitochondrial; mouse model; necrocytosis; neonatal human; neoplastic; neoplastic transformation; nerve stem cell; nervous system development; nervous system disorder; neural; neural degeneration; neural precursor cell; neural progenitor cells; neurodegeneration; neurological disease; neuronal degeneration; neuronal progenitor; neuronal progenitor cells; neuropathology; neuropsychiatric; neuropsychiatry; novel; pathway; pediatric; premature childbirth; premature delivery; preterm delivery; programs; psychological disorder; relating to nervous system; research study; response; social role; stem; stroke; transplant; tumors in the brain; vertebrata",Molecular Characterization of Neural Stem Cell Apoptosis,,41962,NOMD,Neural Oxidative Metabolism and Death Study Section,,7,314016,
7760198,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS042213-08,,NINDS:252207;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"GARRIGA, GIAN ;",1915543;,5R01NS042213,09/01/2001,01/31/2011,Adopted; Apoptotic; C elegans; C.elegans; Caenorhabditis elegans; Cancers; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell division; Cells; Development; Event; Family suidae; GRP-1; Genes; Genetic Alteration; Genetic Change; Genetic defect; Goals; Intracellular Communication and Signaling; Malignant Neoplasms; Malignant Tumor; Mediating; Modeling; Mutation; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Nucleus; Pathway interactions; Pigs; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Protein; Research; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Suidae; Swine; Testing; biological signal transduction; cell type; daughter cell; experiment; experimental research; experimental study; gastrin-releasing peptide 1; genome mutation; human disease; interest; malignancy; neoplasm/cancer; neural precursor cell; neuroblast; neuronal; pathway; porcine; receptor; research study; social role; suid,Genes controlling asymmetric cell divisions during C. elegans development,,42213,NCF,Neurogenesis and Cell Fate Study Section,,8,252207,
7754648,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS042304-09,,NINDS:358412;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"STRITTMATTER, STEPHEN M;",1876743;,5R01NS042304,07/01/2001,01/31/2011,"21+ years old; APP Secretase; ASY protein, human; Ablation; Acute; Address; Adult; After Care; After-Treatment; Aftercare; Alleles; Allelomorphs; Amyloid Precursor Protein Secretase; Apoplexy; Assay; Axon; Behavioral; Bioassay; Biologic Assays; Biological Assay; Brain; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cataloging; Catalogs; Cell Communication and Signaling; Cell Signaling; Cells; Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Complex; Conflict; Conflict (Psychology); Corticospinal Tracts; Craniocerebral Trauma; Cytochrome Oxidase; Cytochrome-c Oxidase (Complex IV); DNA Sequence Rearrangement; Data; Dependence; Dominance, Ocular; EGFR; ERBB Protein; ERBB1; Electron Transport Complex IV; Electrophysiology; Electrophysiology (science); Elements; Encephalon; Encephalons; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Exhibits; Expression Profiling; Expression Signature; Eye Dominance; FLR; Failure (biologic function); Ferricytochrome-c[{..}]oxygen oxidoreductase; Ferrocytochrome c Oxygen Oxidoreductase; Fiber; GP80-LNGFR; Gene Deletion; Gene Expression; Gene Targeting; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Intervention; Glia; Glial Cells; Growth; HER1; Head Injuries; Head Trauma; Homolog; Homologous Gene; Homologue; Human, Adult; In Vitro; Injuries, Craniocerebral; Injury; Integral Membrane Protein; Intervention, Genetic; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Investigators; Knockout Mice; Knowledge; Kolliker's reticulum; Ligand Binding; Ligands; MS (Multiple Sclerosis); Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Molecular; Molecular Biology, Gene Therapy; Molecular Fingerprinting; Molecular Profiling; Motor; Multiple Sclerosis; Murine; Mus; Mutant Strains Mice; Myelin; Myelopathy, Traumatic; NGF Receptor; NGFR; NGFR Protein; NI-220 protein; NI-250 protein; NI-35 protein; NI-35-250; NRVS-SYS; Natural regeneration; Nerve Cells; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity; Nerve Unit; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neural Cell; Neuraxis; Neurite Growth Inhibitor 220; Neurite Outgrowth Inhibitor; Neurocyte; Neuroendocrine-Specific Protein C Like (foocen); Neuroglia; Neuroglial Cells; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurons; Neurophysiology / Electrophysiology; Neurotropin Receptor p75; Nogo protein; Nogo-A; Nogo-A protein; Nogo-B protein; Nogo-C protein; Non-neuronal cell; Null Mouse; Ocular Dominance; PKC; Pathway interactions; Pharmacological Treatment; Phenotype; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physiologic; Physiological; Programs (PT); Programs [Publication Type]; Protein Kinase C; Proteins; Publishing; RTN-x protein, human; RTN4 protein, human; Rearrangement; Receptor Gene; Receptor Protein; Receptor Signaling; Receptor, EGF; Receptor, Nerve Growth Factor; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; Recovery; Regeneration; Research Personnel; Researchers; Reticulon 4; Role; Sclerosis, Disseminated; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Somatosensory Cortex; Specificity; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Staining method; Stainings; Stains; Stroke; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic; Therapeutic Intervention; Therapy, DNA; Time; Tissue Growth; Transforming Growth Factor alpha Receptor; Translating; Translatings; Transmembrane Protein; Variant; Variation; Vascular Accident, Brain; Vibrissae; Visual Cortex; Whiskers; Work; adult human (21+); axon growth; axonal growth; axonal sprouting; barrel cortex; base; biological signal transduction; brain attack; c-erbB-1; c-erbB-1 Protein; cerebral vascular accident; critical period; cytochrome c oxidase; desensitization; dorsal column; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experience; failure; gene deletion mutation; gene product; gene therapy; genetic therapy; gp75 NGFR; human RTN4 protein; imaging modality; improved; in vivo; inhibitor; inhibitor/antagonist; insight; insular sclerosis; intervention therapy; language translation; loss of function; molecuar profile; molecular signature; mouse mutant; nerve cement; neurite growth inhibitor 35-350; neuronal; ontogeny; p75 neurotrophin receptor; p75(NTR); p75NTR; pathway; post stroke; posterior column; poststroke; prevent; preventing; programs; proto-oncogene protein c-erbB-1; receptor; receptor function; reconstitute; reconstitution; regenerate; response; reticulon 4 protein, human; secretase; social role; somesthetic sensory cortex; stroke; success; tissue culture; visual cortical",Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration,,42304,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,9,358412,
7762844,R01,NS,5,,03/01/2010,02/28/2011,,5R01NS042719-07,,NINDS:334590;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NEUROLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HAVTON, LEIF A;",1909648;,5R01NS042719,12/01/2001,02/28/2011,"2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-; 21+ years old; Acute; Adult; Apopain; Apoptotic; Bilateral; Bladder; C 5b-9; C5b-9; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Cauda Equina; Cell Death; Cell/Tissue, Immunohistochemistry; Cessation of life; Clinical; Combined Modality Therapy; Common Rat Strains; Complement; Complement Activation; Complement Complex C5b-9; Complement Inactivators; Complement Inhibitors; Complement Membrane Attack Complex; Complement Proteins; Complement Receptor; Conus Medullaris; Conus Medullaris Syndromes; Cysteine Protease CPP32; Cytolytic Terminal Complement Complex; Death; Development; Electron Microscopy; Exhibits; Grant; Human, Adult; IHC; INFLM; Immunohistochemistry; Immunohistochemistry Staining Method; Impairment; Implant; Inflammation; Injury; Intestinal; Intestines; Investigators; Knowledge; Lesion; Light; Lower Extremity; Lower Limb; Lower urinary tract; Lytic; MAC393 antigen; Mammals, Rats; Mediating; Medulla Spinalis; Membrane Attack Complex; Membrum inferius; Methods and Techniques; Methods, Other; Minocycline; Modeling; Motor; Motor Cell; Motor Neurons; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Myelopathy, Traumatic; Nerve; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neuron Degeneration; Neurons; Operation; Operative Procedures; Operative Surgical Procedures; Outcome Measure; PARP Cleavage Protease; Pain; Painful; Palsy; Paralysed; Paralysis, Legs; Paralysis, Lower Extremities; Paralysis, Lower Limbs; Paraparesis; Paraplegia; Patients; Pharmacological Treatment; Photoradiation; Plant Roots; Plegia; Programs (PT); Programs [Publication Type]; Rat; Rattus; Recombinants; Reflex; Reflex action; Research; Research Personnel; Researchers; SCA-1; SGP-2 protein; SGP2; SP 40,40 protein; SREBP Cleavage Activity 1; Sensory; Sex Disorders; Sexual Dysfunction; Spinal; Spinal Column; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Spine; Structure of conus medullaris; Study models; Surface; Surgical; Surgical Interventions; Surgical Procedure; Syndrome; Syndromes, Conus Medullaris; System; System, LOINC Axis 4; TRPM-2 protein; TRPM2; Techniques; Terminal Complement Complex; Tetracycline Antibiotic; Tetracyclines; Therapeutic; Time; Translational Research; Translational Research Enterprise; Translational Science; Trauma; Urethral sphincter; Urinary System, Bladder; Urodynamic; Urodynamics; Ventral Nerve Root; Ventral Roots; Vertebral column; X-ray-inducible protein 8; XIP8 protein; Yama; Yama protein; adult human (21+); apoJ protein; apolipoprotein J; axon regeneration; axonal regeneration; backbone; bowel; caspase-3; clinical relevance; clinically relevant; clusterin; combination therapy; combined modality treatment; combined treatment; complement lysis inhibitor; complement pathway regulation; complement-associated protein SP-40,40 protein; conus medullaris; cysteine protease P32; implantation; improved; inhibitor; inhibitor/antagonist; injury and repair; ionizing radiation-induced protein-8; motoneuron; multimodality therapy; necrocytosis; neural; neural degeneration; neurodegeneration; neuronal; neuronal degeneration; neuropathic pain; neuroprotection; painful neuropathy; paralysis; paralytic; paraplegic; programs; regenerative; reinnervation; relating to nervous system; repair; repaired; response; root; root implantation; sulfated glycoprotein 2; surgery; testosterone-repressed prostate message-2 protein; translation research enterprise; treatment strategy; urinary bladder",Repair of Bladder Function after Cauda Equina Injury,,42719,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,7,334590,
7766958,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS042867-08,,NINDS:226656;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,NONE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HOPKINS, WILLIAM D;",1864622;,5R01NS042867,06/01/2002,01/31/2011,"Acetylcholine Hydrolase; Acetylcholinesterase; Acoustic; Acoustics; Apes; Area; Area, Broca; Area, Wernicke; Astrocytes; Astrocytus; Astroglia; Behavior; Behavioral; Body Tissues; Brain; Brain region; Broca's area; Brodmann's area; Buccal Cavity; Cavitas Oris; Cerebral Dominance; Cessation of life; Communication; Connector Neuron; Data; Death; Development; Dominance, Cerebral; Dominances, Cerebral; Encephalon; Encephalons; Evolution; Facial asymmetry; Goals; Hand; Handedness; Head and Neck, Buccal Cavity; Hemifacial Microsomia; Individual; Individual Differences; Inferior Frontal Convolution; Inferior frontal gyrus; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Language; Laterality; Left; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Primates; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Molecular; Motor; Mouth; Movement; NFP; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurofilament Proteins; Neurons; Nuclear Magnetic Resonance Imaging; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oral cavity; Parvalbumins; Pongidae; Population; Primates; Production; Pyramidal neuron; Scanning; Sound; Sound - physical agent; Speech; Staining method; Stainings; Stains; Stimulus; Structure of Broca's area; Temporal Lobe; Testing; Tissues; Variant; Variation; Wernicke Area; Work; Zeugmatography; acetylcholine acetylhydrolase; body movement; brain laterality; brain tissue; cerebral lateralization; choline esterase I; cognitive function; density; great ape; hemifacial microsomia (HM); hemispheric specialization; hippocampal pyramidal neuron; interest; neurobiological mechanism; neuronal; preference; sound; species difference; temporal cortex; temporal lobe/cortex",Hemispheric Specialization and Communication,,42867,COG,Cognitive Neuroscience Study Section,,8,226656,
7751895,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS043038-08,,NINDS:330366;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROLOGY,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"SHASHIDHARAN, PULLANIPALLY ;",1884155;,5R01NS043038,07/01/2001,01/31/2013,"0-11 years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Affect; Animal Welfare; Animals; Basal Ganglia; Basal Nuclei; Base Pairing; Behavioral; Bibliography; Blepharospasm; Brain; Brain Stem; Brainstem; Budgets; Cell Nucleus; Cervical Dystonia; Child; Child Youth; Childhood Onset Dystonias; Children (0-21); Clinical; Common Rat Strains; Corpus Striatum; Corpus striatum structure; Country; DYT1 gene; Data; Disease; Disorder; Documentation; Dopamine; Dysfunction; Dyskinesia Syndromes; Dystonia; Dystonias, Childhood Onset; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Eye Movements; Frequencies (time pattern); Frequency; Functional disorder; Genetic Alteration; Genetic Change; Genetic defect; Glutamates; Glutamic Acid; Goals; Human; Human, Child; Human, General; Hydroxytyramine; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Knockout Mice; Knowledge; L-Glutamate; L-Glutamic Acid; Laboratories; Lead; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microdialysis; Modeling; Movement Disorder Syndromes; Movement Disorders; Murine; Mus; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Dystonia; Muscle Tissue; Muscle, Involuntary; Muscle, Smooth; Muscular Contraction; Mutation; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neuron-Specific Enolase; Neuronal Transmission; Neurons; Nucleus; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Pathology; Patients; Pattern; Pb element; Phenotype; Physiopathology; Position; Positioning Attribute; Posture; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Rat; Rattus; Reports, Progress; Research; Research Ethics Committees; Research Resources; Resources; Role; Science of neurochemistry; Screening procedure; Severities; Smooth muscle (tissue); Stream; Striate Body; Striatum; Structure; Surgical; Surgical Interventions; Surgical Procedure; Syndrome; Thalamic structure; Thalamus; Therapeutic Agents; Torsin A; TorsinA; Transgenic Mice; Transgenic Model; Two Hybrid; Vertebrate Animals; Vertebrates; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; abstracting; base; children; cost; disease/disorder; expiration; extracellular; gene product; genome mutation; heavy metal Pb; heavy metal lead; human subject; improved; insight; interest; mouse model; mutant; neurochemistry; neuronal; neurotransmission; new therapeutics; next generation therapeutics; novel therapeutics; overexpression; pathophysiology; programs; rapid eye movement; screening; screenings; social role; striatal; surgery; thalamic; vertebrata; yeast two hybrid system; youngster",Brain TorsinA and childhood-onset Dystonia,,43038,ZRG1,Special Emphasis Panel,,8,330366,
7760590,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS043142-11,,NINDS:481774;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,NEUROSCIENCES,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"HAYDON, PHILIP G;",1864459;,5R01NS043142,07/15/2001,01/31/2011,"1,2-diacylglycerol; Adenosine; Afferent Pathways; Arm; Astrocytes; Astrocytus; Astroglia; Attenuated; Behavioral; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Convulsants; DAG; Detection; Development; Diacylglycerols; Diglycerides; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Funding; Glutamates; Hand; Hydrolysis; Intracellular Communication and Signaling; Investigation; Investigators; L-Glutamate; L-Serine; Lecithinase C; Long-Term Potentiation; Mammals, Mice; Mediating; Mice; Mice, Transgenic; Molecular Genetic; Molecular Genetics; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Neurotransmitters; Nucleosides; Pathway interactions; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phospholipase C; Photons; Population; Position; Positioning Attribute; Potentials, Synaptic; Preparation; Programs (PT); Programs [Publication Type]; Purines; Pyramidal neuron; Receptor Protein; Receptors, N-Methylaspartate; Receptors, Synaptic; Research Personnel; Researchers; Role; Seizure Disorder; Seizures; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Source; Synapses; Synaptic; Synaptic Potentials; Synaptic Receptors; Synaptic Transmission; Testing; Transgenes; Transgenic Animals; Transgenic Mice; Upper arm; Work; adult animal; awake; biological signal transduction; chemical release; diacylglycerol; diglyceride; epilepsia; epileptiform; epileptogenic; extracellular; genetic manipulation; hippocampal pyramidal neuron; insight; lipophosphodiesterase I; mature animal; neuronal; neuronal excitability; neurotransmitter release; novel; pathway; phosphatidylcholine cholinephosphohydrolase; postsynaptic; presynaptic; prevent; preventing; programs; purine; receptor; social role; therapeutic target",Reciprocal signaling between synapses and astrocytes,,43142,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,11,481774,
7735570,R01,NS,5,,12/01/2009,11/30/2010,,5R01NS043174-08,,NINDS:341087;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,NEUROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SCHERER, STEVEN S;",1888784;,5R01NS043174,04/01/2002,11/30/2011,"4-Aminopyridine; 4-Pyridinamine; ATP phosphohydrolase (Na+ K+ transporting); Action Potentials; Address; Affect; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Autoregulation; Axon; Belief; Birth; Cellular biology; Charcot Marie Disorder; Charcot Marie Muscular Atrophy; Charcot Marie Tooth Disorder; Charcot Marie Tooth muscular atrophy; Charcot-Marie Disease; Charcot-Marie-Tooth; Charcot-Marie-Tooth Disease; Charcot-Marie-Tooth neuropathy; Common Rat Strains; Connexins; Data; Demyelinating Diseases; Demyelinating Disorders; Demyelinations; Disease; Disorder; Electrophysiology; Electrophysiology (science); Enzymes; Event; FLR; Failure (biologic function); Gamstorp-Wohlfart Syndrome; Gap Junction Proteins; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glia; Glial Cells; Hereditary; Homeostasis; Immunoelectron Microscopy; Inherited; Investigators; Ion Channels, Potassium; Ions; Isaacs syndrome; Isaacs-Mertens Syndrome; Isoforms; K channel; Knockout Mice; Kolliker's reticulum; Kv1.2' channel; Link; Mammals, Mice; Mammals, Rats; Membrane; Mice; Mice, Knock-out; Mice, Knockout; Microscopy, Immuno-Electron; Microscopy, Immunoelectron; Molecular; Murine; Mus; Mutation; Myelin; Myokymia, Continuous; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Na+ K+ ATPase; Nerve; Nervous; Neuroglia; Neuroglial Cells; Neuromyotonia; Neuropathy; Neurophysiology / Electrophysiology; Nodal; Non-neuronal cell; Null Mouse; Optics; Parturition; Pathway interactions; Peripheral Nerves; Peroneal Muscular Atrophy; Physiological Homeostasis; Potassium Channel; Potassium Pump; Programs (PT); Programs [Publication Type]; Protein Isoforms; Pseudomyotonia; Pseudomyotonia Syndrome of Isaacs; Pymadine; Quantal Squander; Racial Segregation; Ranvier's Nodes; Rat; Rattus; Research Personnel; Researchers; Role; Science of Anatomy; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump; Structure; Syndrome of Continuous Muscle Activity; Time; Unpublished Works (PT); Unpublished Works [Publication Type]; Work; anatomy; cell biology; channel blockers; dendrotoxin; disease/disorder; experiment; experimental research; experimental study; failure; genome mutation; human disease; membrane structure; model organism; mutant; myelination; nerve cement; neuropathic; neuropathic pain; novel; novel therapeutic intervention; painful neuropathy; pathway; programs; research study; segregation; social role; sodium potassium exchanging ATPase; unpublished works",Axonal alterations in demyelinating diseases,,43174,NDGB,Neural Degenerative Disorders and Glial Biology Study Section,,8,341087,
7763174,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS043196-06,,NINDS:333507;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"ARNOLD, ARTHUR P;",1892395;,5R01NS043196,04/01/2002,02/28/2014,"21+ years old; Absence of pain sensation; Absence of sensibility to pain; Adult; Analgesia Tests; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Behavior; Behavioral; Biological; Biological Factors; Brain; Brain Diseases; Brain Disorders; Cell Communication and Signaling; Cell Signaling; Cells; Contin, MS; DNA Content; DNA Index; DNA Ploidy; Development; Disease; Disorder; Effectiveness; Encephalon; Encephalon Diseases; Encephalons; Factor, Biologic; Feels no pain; Gene variant; Genes; Genetic Diversity; Genetic Variation; Genome; Genomics; Genotype; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Gonosomes; Health; Hormonal; Human, Adult; Individual; Infumorph; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigation; Kadian; Lead; Light; Link; Locomotor Activity; MSir; Mammals, Mice; Measures; Mice; Modeling; Molecular; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Motor; Motor Activity; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Natural Products; Nervous; Nervous System, Brain; Neuropathy; No sensitivity to pain; Nociception; Nociception Tests; Nociceptive Impulse; Nociceptive Stimulus; Opioid; Opioid Analgesics; Oramorph; Oramorph SR; Pain Assessment; Pain Measurement; Pb element; Phenotype; Photoradiation; Ploidies; Predisposition; Protected Sex; Recombinant Inbred Strain; Research; Responsible Sex; Responsible sexual behavior; Roxanol; Safe Sex; Sex Characteristics; Sex Chromosomes; Sex Differences; Sex Hormones; Sex Steroid Hormones; Signal Transduction; Signal Transduction Systems; Signaling; Site; Statex SR; Steroid Compound; Steroids; Stress; Susceptibility; System; System, LOINC Axis 4; Testing; Transgenic Organisms; Variation (Genetics); Woman; Work; Y Chromosome; adult human (21+); allelic variant; analgesia; base; behavior test; behavioral test; biological signal transduction; brain behavior; chromosome complement; disease/disorder; gastrointestinal; gastrointestinal function; gender difference; gonadal steroids; heavy metal Pb; heavy metal lead; men; men's; mouse model; neural; neuropathic; nociceptive; novel; public health relevance; relating to nervous system; response; sex; sex steroid; sexual dimorphism (noncellular); transgenic",Sex chromosome effects on neural developement," Narrative Men and women show significant differences in behavior, and in their susceptiblity to diseases of the brain. The proposed research aims to understand the biological origins of such sex differences, especially those differences that are caused by the sex differences in genomic representation of X and Y genes. Understanding the molecular basis of sex differences will shed light on factors that protect the brain from disease.",43196,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,6,333507,
7753628,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS043277-08,,NINDS:328093;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,BIOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"AIZENMAN, ELIAS ;",1905414;,5R01NS043277,04/01/2002,12/31/2012,"Acute; Affect; Apoplexy; Area; Autoregulation; Binding Proteins; Brain; Buffers; CSAIDS Binding Protein; CSBP; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Cell Communication and Signaling; Cell Death; Cell Death Process; Cell Death Signaling; Cell Death Signaling Process; Cell Signaling; Cell Survival; Cell Viability; Cell-Death Protease; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Common Rat Strains; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; EC 2.7.2-; ERK MAP Kinases; Embryo; Embryonic; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Event; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Funding; Gene Expression; Generations; Goals; Grant; Homeostasis; Hortega cell; ICE-like protease; In Vitro; Injury; Intracellular Communication and Signaling; Investigation; Ion Channels, Potassium; K channel; Lead; Ligand Binding Protein; Link; MAP Kinase 14; MAP Kinase Mxi2; MAP kinase; MAPK; MAPK14 protein, human; MAX-Interacting Protein 2; Mammals, Rats; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Metallothionein; Metals; Microglia; Mitogen-Activated Protein Kinase p38Alpha; Mitogen-Activated Protein Kinases; Modeling; Molecular; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neuron Degeneration; Neuronal Injury; Neurons; Oxidants; Oxidizing Agents; PKC; Pathway interactions; Pb element; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Physiological Homeostasis; Position; Positioning Attribute; Potassium Channel; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Kinase C; Public Health; Publications; Rat; Rattus; Research; Role; Scientific Publication; Seizure Disorder; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Stimulus; Stress-Activated Protein Kinase 2A; Stroke; Synapses; Synaptic; System; System, LOINC Axis 4; Thalamic structure; Thalamus; Therapeutic Intervention; Threonine/Tyrosine Protein Kinase; Trauma; V (voltage); Vascular Accident, Brain; Work; Zinc; Zn element; biological signal transduction; brain attack; caspase; cerebral vascular accident; computerized data processing; cystein protease; cystein proteinase; cysteine endopeptidase; data processing; electron acceptor; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; extracellular signal related kinase; gitter cell; heavy metal Pb; heavy metal lead; human MAPK14 protein; in vivo; in vivo Model; intervention therapy; mesoglia; microglial cell; microgliocyte; necrocytosis; nervous system disorder; neural degeneration; neurodegeneration; neurodegenerative illness; neurological disease; neuron cell death; neuron injury; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; new therapeutic target; new therapeutics; next generation therapeutics; nitrosative stress; novel; novel therapeutics; p38 MAP Kinase; p38 MAPK; p38 Mitogen Activated Protein Kinase; p38Alpha EXIP; pathway; perivascular glial cell; prevent; preventing; programs; public health medicine (field); public health relevance; research study; signal processing; social role; stroke; thalamic; voltage",Liberation of Intracellular Zinc and Neuronal Cell Death," RELEVANCE TO PUBLIC HEALTH Results from these studies will provide fundamental information about the cellular mechanisms responsible for a host of neurological disorders, including stroke, trauma and epilepsy. With this information, we hope to uncover novel therapeutic strategies to prevent or halt the progression of these and other neurodegenerative conditions.",43277,NOMD,Neural Oxidative Metabolism and Death Study Section,,8,328093,
7752778,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS043288-07,,NINDS:327690;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"RICHERSON, GEORGE B;",1886840;,5R01NS043288,04/01/2002,01/31/2012,"4-Amino-5-hexenoic Acid; 4-Aminobutanoate[{..}]2-oxoglutarate aminotransferase; 4-Aminobutanoic Acid; 4-Aminobutyrate Transaminase; 4-Aminobutyrate aminotransferase; 4-Aminobutyric Acid; Action Potentials; Address; Affect; Affinity; Aminalon; Aminalone; Aminobutyrate Aminotransferase; Ammon Horn; Anions; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Apoplexy; Assay; Astrocytes; Astrocytus; Astroglia; Behavior; Bioassay; Biologic Assays; Biological Assay; Blood Coagulation Factor IV; Brain; Butanoic acid, 4-amino-; CHO Cells; Ca++ element; Calcium; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chinese Hamster Ovary Cell; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Coagulation Factor IV; Complex; Cornu Ammonis; Coupled; Data; Dependence; Disease; Disorder; Elements; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Equilibrium; Extracellular Fluid; Factor IV; Far Go; FarGo; Figs; Figs - dietary; Floor; Frequencies (time pattern); Frequency; GABA; GABA Aminotransferase; GABA Transaminase; GABA transporter; GABA-alpha-Ketoglutarate Aminotransferase; Glia; Glial Cells; Goals; HPLC; Health; High Pressure Liquid Chromatography; Hippocampus; Hippocampus (Brain); Intracellular Communication and Signaling; Ischemia; Knock-out; Knockout; Knockout Mice; Kolliker's reticulum; Lead; Link; Mammals, Mice; Measurement; Measures; Mediating; Membrane; Membrane Potentials; Methods; Mice; Mice, Knock-out; Mice, Knockout; Models, Theoretic; Murine; Mus; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurological Disorders; Neuronal Transmission; Neurons; Neurotransmitters; Non-neuronal cell; Null Mouse; Pb element; Physiologic; Physiological; Physiology; Play; Proteins; Receptor Protein; Regulation; Relative; Relative (related person); Rest; Resting Potentials; Ringer's solution; Role; Seizure Disorder; Seizures; Side; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Slice; Source; Stimulus; Stroke; Swelling; Synapses; Synaptic; Synaptic Transmission; Synaptic Vesicles; System; System, LOINC Axis 4; Testing; Theoretical model; Time; Transmembrane Potentials; VESCL; Vacuum; Vascular Accident, Brain; Vesicle; Vigabatrin; Wild Type Mouse; Work; balance; balance function; beta-Alanine Ketoglutarate Aminotransferase; biological signal transduction; brain attack; brain control; cerebral vascular accident; design; designing; disease/disorder; epilepsia; epileptiform; epileptogenic; excitotoxicity; experiment; experimental research; experimental study; extracellular; gamma-Aminobutyric Acid; gamma-Vinyl-GABA; gamma-Vinyl-gamma-Aminobutyric Acid; gene product; heavy metal Pb; heavy metal lead; hippocampal; in vivo; insight; membrane structure; mind control; nerve cement; nervous system disorder; neurological disease; neuronal; neurotransmission; neurotransmitter release; neurotransmitter reuptake; novel; receptor; research study; response; reuptake; social role; stoichiometry; stroke",Non-vesicular GABA release via GABA transporter reversal,,43288,ZRG1,Special Emphasis Panel,,7,327690,
7878589,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS043530-07,,NINDS:663932;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,PEDIATRICS,03,043207562,US,CT,065208047,YALE UNIVERSITY,"GRUEN, JEFFREY R;",1902623;,5R01NS043530,04/01/2002,01/31/2011,"0-11 years old; 15q; 21+ years old; 6p21.3; 6p22; Achievement; Achievement Attainment; Actins; Admixture; Adult; Affect; Age; Alleles; Allelomorphs; Behavior; Birth; Bundling; Characteristics; Child; Child Youth; Children (0-21); Chromosome 15 Distal Arm; Chromosome 15 Long Arm; Clinical; Cognitive; DNA; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dendrites; Deoxyribonucleic Acid; Development; Diagnosis; Early Diagnosis; Early identification; Early treatment; Economics; Enhancers; Environment; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Functional Magnetic Resonance Imaging; Generalized Growth; Genes; Genetic; Genetic Screening; Genotype; Germany; Goals; Growth; Haplotypes; Heritability; Home; Home environment; Human, Adult; Human, Child; Individual; Intelligence; Intervening Sequences; Introns; Italy; Language; Lead; Linkage (Genetics); Literacy Programs; Longitudinal Studies; MRI, Functional; Magnetic Resonance Imaging, Functional; Measures; Medical Records; Modeling; Morbidity; Morbidity - disease rate; Mothers; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Parents; Parturition; Pathogenesis; Pb element; Performance; Population; Population Attributable Risks; Predictive Value; Prevalence; Prevention program; Preventive Intervention; Programs (PT); Programs [Publication Type]; Programs, Literacy; Reading; Reading Disabilities; Reading disability; Reporting; Research Resources; Resources; Risk; Role; Sampling; Schools; Screening procedure; Students; Testing; Tissue Growth; Translating; Translatings; Twin Studies; Work; adult human (21+); association test; attributable fraction; behavior measurement; behavioral measure; behavioral measurement; children; clinical data repository; clinical data warehouse; cohort; cost; cost effectiveness; data repository; demographics; early detection; environment effect on gene; fMRI; gene environment interaction; genetic association; genetic linkage; gray matter; heavy metal Pb; heavy metal lead; intervention program; language translation; long-term study; migration; neuronal; non-genetic; ontogeny; pollutant; prenatal; preventional intervention strategy; programs; public health relevance; relational database; remediation; screening; screenings; social; social role; substantia grisea; tool; unborn; youngster",Discovery of the 6p21.3 Reading Disability Gene,,43530,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,7,663932,
7767659,R01,NS,5,,02/01/2010,01/31/2011,PA-07-199,5R01NS044158-07,,NINDS:436338;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,PHYSIOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"SUREWICZ, WITOLD K;",2428758;,5R01NS044158,06/15/2002,01/31/2014,"Accounting; Amino Acids; Amyloid Fibrils; Animals; Architecture; Biosynthetic Proteins; Bovine Species; Bovine Spongiform Encephalopathy; Brain; C-terminal; CJD; CJDs (Creutzfeldt-Jakob Disease); Cattle; Central Nervous System; Chronic Wasting Disease; Coupled; Creutzfeldt-Jacob Disease; Creutzfeldt-Jakob Disease; Creutzfeldt-Jakob Syndrome; Cricetinae; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deposit; Deposition; Deuterium; Disease; Disorder; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Encephalitis, Bovine Spongiform; Encephalon; Encephalons; Encephalopathies; Encephalopathy, Bovine Spongiform; Endopeptidase K; Engineering / Architecture; Esteroproteases; Fibrils, Amyloid; H element; H2 isotope; Hamsters; Hamsters, Golden; Hamsters, Syrian; Human; Human, General; Hydrogen; Hydroxyl; Hydroxyl Radical; Jakob-Creutzfeldt Disease; Macromolecular Structure; Mad Cow Disease; Mammals, Hamsters; Man (Taxonomy); Man, Modern; Markers, Surrogate; Mass Spectrum; Mass Spectrum Analysis; Mediating; Mesocricetus auratus; Methods; Methods and Techniques; Methods, Other; Mink; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Molecular Structure; N-terminal; NH2-terminal; NMR Spectroscopy; Nature; Nervous System Diseases; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Nucleic Acids; Paramagnetic Resonance; Peptidases; Peptide Hydrolases; Photometry/Spectrum Analysis, Mass; PrP; PrP 33-35; PrP Proteins; PrP Sc; PrP amyloid; PrP(Sc); PrP-res; PrPSc; PrPSc Proteins; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion Proteins; Prion-Induced Disorder; Prions; Procedures; Process; Property; Property, LOINC Axis 2; Protease K; Proteases; Proteinase K; Proteinases; Proteins; Proteolytic Enzymes; Public Health; Reaction; Recombinant Proteins; Recombinants; Research; Resistance; Resolution; Rida; Scrapie; Scrapie PrP; Scrapie PrP 33-35; Site; Sp 33-35; Spectrometry, Mass; Spectroscopy, ESR; Spectroscopy, Mass; Spectroscopy, NMR; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spin Labels; Spongiform Encephalopathies, Transmissible; Spongiform Encephalopathy, Subacute; Structure; Surrogate Markers; Syrian Hamsters, Golden; Techniques; Time; Transmissible Dementias; Transmission; Tritirachium Alkaline Proteinase; Wasting Disease, Chronic; Work; aminoacid; base; bovid; bovine; cervid; conformation; conformational conversion; conformational state; conformational transition; conformer; cow; disease phenotype; disease-associated PrP; disease/disorder; electron paramagnetic resonance spectroscopy; experience; gene product; insight; insoluble aggregate; nervous system disorder; neurodegenerative illness; neurological disease; nuclear magnetic resonance spectroscopy; pathogen; prion hypothesis; protein aggregate; protein misfolding cyclic amplification; protein-only hypothesis; public health medicine (field); recPrP; recombinant PrP; resistant; solid state nuclear magnetic resonance; spongiform degeneration; spongiform encephalopathy; transmission process",Conformational conversions of prion protein," RELEVANCE Prions are infectious proteins that are believed to cause transmissible spongiform encephalopathies (TSEs), a group of fatal neurological disorders including Creutzfeldt-Jakob disease in humans, `mad cow' disease in cattle, and chronic wasting disease in cervids. Understanding the molecular basis of these disorders and the mechanism of their transmissibility is of major importance for public health, especially in view of indications that some animal forms of TSE diseases may cross interspecies transmissibility barriers, posing a threat to humans.",44158,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,,7,436338,
7755366,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS044225-08,,NINDS:243534;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,EDMONTON,CANADA,,,208095844,CA,AB,T6G 2E1,UNIVERSITY OF ALBERTA,"MUSHAHWAR, VIVIAN K.;",2503315;,5R01NS044225,09/01/2002,01/31/2012,"21+ years old; Address; Adult; Affect; Animals; Axon; Body Tissues; Cats; Cells; Clinical; Coupled; Development; Dimensions; Domestic Cats; Effectiveness; Electric Stimulation; Electrical Stimulation; Environment; Extremities; FOS gene; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fiber; Flexor; Future; G0S7; Generations; Goals; Hair; Horns; Human; Human Volunteers; Human, Adult; Human, General; Image; Imaging Procedures; Imaging Techniques; Implant; Individual; Injury; Kinetic; Kinetics; Label; Laboratories; Lead; Leg; Limb structure; Limbs; Load-Bearing; Loadbearing; Location; Locomotion; Lower Extremity; Lower Limb; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Cats; Man (Taxonomy); Man, Modern; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Membrum inferius; Methods; Methods and Techniques; Methods, Other; Modification; Motor; Movement; Myelopathy, Traumatic; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Non-Trunk; Nuclear Magnetic Resonance Imaging; Outcome; Palsy; Paralysed; Pattern; Pb element; Peripheral Nerves; Physical Health Services / Rehabilitation; Physiologic; Physiological; Plegia; Procedures; Protooncogene FOS; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Resolution; Safety; Sensory; Site; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stimulus; Structure; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Testing; Time; Tissues; Ventral Horn of the Spinal Cord; Volunteers, Human; Walking; Weight; Weight-Bearing; Weight-Bearing state; Weightbearing; Zeugmatography; adult human (21+); analog; base; body movement; c fos; c-fos Gene; c-fos Proto-Oncogenes; design; designing; experiment; experimental research; experimental study; extracellular; heavy metal Pb; heavy metal lead; imaging; implantation; improved; in vivo; intraspinal microstimulation; kinematics; limb movement; nervous system disorder; neural circuit; neural circuitry; neurological disease; neuronal; paralysis; paralytic; rehabilitative; research study; spinal cord regeneration; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Intraspinal microstimulation for restoring limb movement,,44225,MTE,Musculoskeletal Tissue Engineering Study Section,,8,243534,
7778266,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS044363-07,,NINDS:330259;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,ANESTHESIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"GARCIA-ANOVEROS, JAIME ;",6993123;,5R01NS044363,07/01/2002,02/28/2014,"Accounting; Address; Afferent Neurons; Anatomic; Anatomical Sciences; Anatomy; Animals; Antibodies; Behavioral; Blood Coagulation Factor IV; Blotting, Western; Body Tissues; Ca++ element; Calcium; Cell Line; Cell Lines, Strains; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Coagulation Factor IV; Cutaneous; Detection; Drugs; Esthesia; Exhibits; Factor IV; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Gene Proteins; Genes; Genetics, in situ Hybridization; IHC; Image; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Ion Channel; Ionic Channels; Ions; Knock-out; Knockout; Knowledge; Mammals, Mice; Measures; Mediating; Medication; Membrane Channels; Messenger RNA; Methods; Mice; Molecular; Murine; Mus; Myxoid cyst; Nerve Cells; Nerve Unit; Neural Cell; Neural Ganglion; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Nociception; Organ; Pain; Painful; Pattern; Perception; Peripheral Nerves; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Position; Positioning Attribute; Property; Property, LOINC Axis 2; Protein Gene Products; Proteins; RNA, Messenger; Receptor Protein; Science of Anatomy; Sensation; Sensory; Sensory Cell Afferent Neuron; Skin; Stimulus; TRP channel; TRP protein; Temperature; Testing; Tissues; Western Blotting; Western Blottings; Western Immunoblotting; anatomy; base; cell type; cold temperature; cultured cell line; drug/agent; gene product; imaging; in situ Hybridization Staining Method; low temperature; mRNA; neuronal; nociceptive; novel; patch clamp; perceptual stimulus; physicochemical phenomena related to the senses; protein blotting; public health relevance; receptor; response; sensory stimulus; somatosensory; warm temperature",Molecular Basis of Somatic Sensation," Project Narrative: relevance Currently known thermosensitive channels do not account for all thermal stimuli we perceive. Furthermore, there is presently no knowledge of how pleasurable or pain- relieving stimuli may be detected other than by decreased activation of nociceptive receptors. The activation of TRPML3 channels by temperature changes when warming from painful cold may contribute to the understanding of both thermal sensation and pain relief.",44363,SCS,Somatosensory and Chemosensory Systems Study Section,,7,330259,
7769523,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS044589-07,,NINDS:303554;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,BIOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"KIM, SEONG-GI ;",1979618;,5R01NS044589,09/10/2002,01/31/2013,"2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; Animal Model; Animal Models and Related Studies; Animal Welfare; Animals; Autoradiography; BOLD response; Bibliography; Blood; Blood Vessels; Blood Volume; Body Tissues; Cats; Cell Communication and Signaling; Cell Signaling; Cerebrovascular Circulation; Cerebrum; Column of Bertini; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Contrast Agent; Contrast Drugs; Contrast Media; Cortical Column; Country; D-arabino-Hexose, 2-deoxy-; Data; Deoxyglucose; Domestic Cats; Ecological impact; Editorial Comment; Editorial Comment (PT); Electrophysiology; Electrophysiology (science); Environment; Environmental Impact; Equipment; Ethics Committees, Research; Event; Eye; Eyeball; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Flavoproteins; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Grant; Human; Human, General; IACUC; IRBs; Image; Imaging Procedures; Imaging Techniques; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigation; Investigators; Journals; Knowledge; Laboratories; MRI, Functional; Magazine; Magnetic Resonance Imaging, Functional; Mammals, Cats; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Measurement; Medical Imaging, Positron Emission Tomography; Metabolic; Methods and Techniques; Methods, Other; Modeling; Moon; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Neurosciences; O element; O2 element; Oxygen; PET; PET Scan; PET imaging; PETSCAN; PETT; Paper; Peer Review; Performance; Perfusion; Physiologic; Physiologic Imaging; Physiological; Physiology; Positron Emission Tomography Scan; Positron-Emission Tomography; Predisposition; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Published Comment; Publishing; Rad.-PET; Radioautography; Radiopaque Media; Rat; Rattus; Relative; Relative (related person); Renal Column of Bertini; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Reticuloendothelial System, Blood; Signal Transduction; Signal Transduction Systems; Signaling; Site; Somatosensory Cortex; Source; Specificity; Structure; Study Type; Susceptibility; Synapses; Synaptic; Technics, Imaging; Techniques; Time; Tissues; United States National Institutes of Health; Universities; Venous; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Visual Cortex; Weight; abstracting; base; biological signal transduction; blood oxygen level dependent; blood oxygenation level dependent response; cerebral blood flow; cerebral circulation; cerebrocirculation; colcothar; experiment; experimental research; experimental study; expiration; fMRI; ferric oxide; hemodynamics; human subject; imaging; improved; insight; iron oxide; magnetic field; model organism; monocular; nano particle; nanoparticle; neural; neuroimaging; neuronal; optic imaging; optical imaging; programs; red iron oxide; relating to nervous system; research study; response; somesthetic sensory cortex; study design; vascular; vertebrata; visual cortical",Neural Correlate of Perfusion Based fMRI,,44589,MEDI,Medical Imaging Study Section,,7,303554,
7763799,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS045130-06,,NINDS:329948;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CAMBRIDGE,UNITED STATES,NONE,08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"MOORE, CHRISTOPHER IRWIN;",1894125;,5R01NS045130,12/01/2002,01/31/2013,"Action Potentials; Air; Anatomic; Anatomical Sciences; Anatomy; Animals; Area; Attention; Au element; Behavior; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; Coagulation Factor IV; Coloring Agents; Common Rat Strains; Connector Neuron; Cyclic Somatostatin; Data; Dependence; Disease; Disorder; Dyes; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Ensure; Environment; Epilepsy; Epileptic Seizures; Epileptics; Evaluation; Factor IV; Frequencies (time pattern); Frequency; Funding; Goals; Gold; Growth Hormone Inhibiting Factors; Growth Hormone-Inhibiting Hormone; Head; Human; Human, General; Image; Imagery; In Vitro; Intercalary Neuron; Intercalated Neurons; Interneuron function; Interneurons; Internuncial Cell; Internuncial Neuron; Label; Laboratories; Literature; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maps; Measures; Mental disorders; Mental health disorders; Methods and Techniques; Methods, Other; Mice; Monitor; Motion; Mouse Strains; Murine; Mus; Neocortex; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Parvalbumins; Perception; Performance; Photons; Play; Preparation; Process; Property; Property, LOINC Axis 2; Psychiatric Disease; Psychiatric Disorder; Rat; Rattus; Resolution; Rodent; Rodentia; Rodentias; Role; SRIH; SRIH-14; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Seizure Disorder; Sensory; Sensory Process; Series; Somatostatin; Somatostatin-14; Somatotropin Release Inhibiting Factors; Somatotropin Release-Inhibiting Hormone; Speed; Speed (motion); Staining method; Stainings; Stains; Stimulus; Surface; System; System, LOINC Axis 4; Techniques; Testing; Time; Unspecified Mental Disorder; Variant; Variation; Vibrissae; Visualization; Whiskers; Work; anatomy; awake; barrel cortex; cell type; dementia praecox; disease/disorder; epilepsia; epileptiform; epileptogenic; excitatory neuron; experiment; experimental research; experimental study; extracellular; flexibility; genetic manipulation; growth hormone release inhibiting factor; homotypical cortex; imaging; in vivo; information processing; innovate; innovation; innovative; insight; isocortex; mental illness; neocortical; neopallium; neural; neuronal; perceptual stimulus; physicochemical phenomena related to the senses; psychological disorder; public health relevance; receptive field; relating to nervous system; remediation; research study; response; schizophrenic; sensory stimulus; sensory system; social role; theories",Systematic Evaluation of Sensory Processing in Distinct Interneuron Types," Project Narrative These studies have direct relevance to understanding basic mechanisms underlying human mental illness. The key hypothesis tested is that distinct types of neocortical interneurons have distinct functions in the in vivo cortex. Maladaptive changes in the exact types we will examine are thought to be causal in Epilepsy and Schizophrenia: Understanding their potentially crucial role in information processing should have direct implications for interpretation of deficits in these maladies, and may potentially suggest avenues for remediation.",45130,SMI,Sensorimotor Integration Study Section,,6,329948,
7753181,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS045684-08,,NINDS:378417;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,CHEMISTRY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"DU BOIS, JUSTIN ;",8912994;,5R01NS045684,02/01/2003,01/31/2012,"1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS-(3aalpha,4alpha,10aR*))-; Animal Welfare; Bibliography; Buccal Cavity; Cavitas Oris; Cells; Complex; Country; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fugu Toxin; Gonyaulax Toxin; Guanidine; Head and Neck, Buccal Cavity; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Ion Channel Protein; Ion Channels, Sodium; Ions; Mitilotoxin; Mouth; Names; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Oral cavity; Poisons; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resources; STX; Saxitonin; Saxitoxin; Sodium Channel; TTX; Tarichatoxin; Tetradotoxin; Tetrodotoxin; Toxic Chemical; Toxic Substance; Toxin; Transmission; V (voltage); Vertebrate Animals; Vertebrates; abstracting; expiration; extracellular; gonyautoxins; guanidinium; human subject; molecular size; neuronal; poison; programs; protein function; puffer fish toxin; small molecule; tool; toxic compound; transmission process; vertebrata; voltage; zetekitoxin AB",Guanidinium Toxins as Tools for Sodium Ion Channel Study,,45684,SBCA,Synthetic and Biological Chemistry A Study Section,,8,378417,
7760956,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS045855-07,,NINDS:250844;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,NEUROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"GELLER, ALFRED I.;",1870081;,5R01NS045855,04/15/2003,01/31/2012,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; AAV vector; Activation of PKC through G protein coupled receptor; Affect; Afferent Neurons; Age; Ammon Horn; Animal Welfare; Animals; Area; Assay; Aujeszky's Disease Virus; Aujeszkys Disease Virus; BNPI protein; Band Shift Mobility Assay; Bandshift Mobility Assay; Behavioral; Bibliography; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Boundary Elements; Brain; Budgets; Chickens; Chromatin; Chromatin Structure; Cloning; Code; Coding System; Cognitive Discrimination; Cognitive deficits; Common Rat Strains; Complex; Convection; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Country; Cytoplasmic Granules; DNA; DNA Binding; DNA Binding Interaction; DNA Methylation; DNA Molecular Biology; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deoxyribonucleic Acid; Development; Discrimination; Discrimination (Psychology); Disease; Disorder; Distal; Dopamine; EBP; Ecological impact; Electrophoretic Mobility Shift Assay; Elements, Boundary; Encephalon; Encephalons; Enhancers; Enkephalin, prepro-; Environment; Environmental Impact; Enzymes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equipment; Ethics Committees, Research; Euchromatin; Evaluation; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gasser's Ganglion; Gasserian Ganglion; Gene Expression; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic; Genetic Intervention; Genome; Globin; Glutamate Carboxy-Lyase; Glutamate Decarboxylase; Glutamates; Glutamic Acid Decarboxylase; Goals; Grant; HHV-1; HSV; HSV-1; HSV-1 vector; HSV1; Helper Viruses; Herpes Simplex Virus; Herpes Simplex Virus 1; Herpes Simplex Virus Type 1; Herpes labialis Virus; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1 (alpha), Suid; Herpesvirus 1, Human; Herpesvirus 1, Suid; Herpesvirus Suis; Herpesvirus hominis; Herpesviruses; Higher Order Chromatin Folding; Higher Order Chromatin Structure; Higher Order Structure; Hippocampus; Hippocampus (Brain); Human; Human herpes simplex virus type 1; Human herpesvirus 1; Human herpesvirus type 1; Human, General; Hybrids; Hydroxytyramine; IACUC; IRBs; Idiopathic Parkinson Disease; Impact, Environmental; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention, Genetic; Investigators; Knowledge; L-Glutamate; L-Glutamate-1-carboxy-lyase; L-Tyrosine,tetrahydrobiopterin[{..}]oxygen oxidoreductase (3-hydroxylating); Learning; Lentiviral Vector; Lentivirinae; Lentivirus; Lentivirus Vector; Lewy Body Parkinson Disease; Life; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Methods; Mobility Shift Assay; Modeling; Molecular Biology; Molecular Biology, Gene Therapy; Molecular Interaction; Monkeys; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neurons; Neurons, Afferent; Neurons, Sensory; Nucleosomes; Paper; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pattern; Phosphate Activated Glutaminase; Physiology; Postdoc; Postdoctoral Fellow; Preparation; Primary Parkinsonism; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Promoter; Promoter Regions; Promoter Regions (Genetics); Promoters (Genetics); Promotor; Promotor (Genetics); Promotor Regions; Promotor Regions (Genetics); Property; Property, LOINC Axis 2; Protein Binding; Protein Kinase C Activation Pathway; Proteins; Pseudorabies virus; Publications; Publishing; Rat; Rattus; Recombinants; Regulation; Reporting; Reports, Progress; Research; Research Associate; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Salaries; Scientific Publication; Semilunar Ganglion; Sensory Cell Afferent Neuron; Simplexvirus; Social Support System; Striate Body; Striatum; Structure of trigeminal ganglion; Subfamily lentivirinae; Suid Herpesvirus 1; Support System; Swine Herpesvirus 1; System; System, LOINC Axis 4; TXT; Testing; Tet; Tetanus Helper Peptide; Text; Therapy, DNA; Time; Trigeminal Ganglias; Trigeminal Ganglion; Tyrosine 3-Monooxygenase; Tyrosine Hydroxylase; Upstream Enhancer; VGLUT1 protein; Vertebrate Animals; Vertebrates; Virion; Virus; Virus Particle; Virus-Lenti; Viruses, General; Wages; Yeasts; abstracting; adeno-associated viral vector; adeno-associated virus vector; adult youth; aged; brain-specific Na-dependent inorganic phosphate cotransporter; deletion analysis; design; designing; disease/disorder; enhancer binding protein; experiment; experimental research; experimental study; expiration; gel shift assay; gene product; gene therapy; genetic promoter element; genetic therapy; granule; herpes simplex i; herpes simplex virus (HSV-1) plasmid vector; herpes virus; herpes virus 1, human; herpesvirus; hippocampal; histone modification; human alphaherpesvirus 1; human herpesvirus 1 group; human subject; improved; in vivo; instructor; monoamine vesicular transport proteins; nervous system disorder; neural; neurodegenerative illness; neurofilament; neurological disease; neuronal; new approaches; novel; novel approaches; novel strategies; novel strategy; overexpression; p-Globin; post-doc; post-doctoral; pre-proenkephalin; preproenkephalin; programs; relating to nervous system; research study; striatal; transcription factor; transfer of a gene; vector; vector control; vector genome; vertebrata; vesicular glutamate transporter 1; vesicular monoamine transporter; virus development; visual learning; young adult",Promoters for Long-term Expression from HSV-1 Vectors,,45855,ZRG1,Special Emphasis Panel,,7,250844,
7762841,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS045940-06,,NINDS:325927;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BURLINGTON,UNITED STATES,NEUROLOGY,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"CIPOLLA, MARILYN J;",2214295;,5R01NS045940,04/01/2003,01/31/2014,"1H-Benz(de)isoquinoline-2(3H)-carboxylic acid, 6-amino-1,3-dioxo-5,8-disulfo-, 2-hydrazide, dilithium salt; Acute; Address; Affect; Animals; Arterioles; Autoregulation; Blindness; Blood - brain barrier anatomy; Blood Circulation; Blood Pressure; Blood Pressure, High; Blood-Brain Barrier; Bloodstream; Brain; Brain Edema; Brain Swelling; Cause of Death; Cell Membrane Permeability; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Cerebral Edema; Cerebrovascular Circulation; Cerebrum; Cessation of life; Chemotherapy-Hormones/Steroids; Circulation; Clinical; Consciousness, Loss of; Convulsions; Cranial Pain; Death; Dilatation; Dilatation - action; Dropsy; Eclampsia; Edema; Emesis; Encephalon; Encephalons; Endocrine Gland Secretion; Endothelial Cells; Event; GFAC; Gestation; Gestosis, EPH; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Head Pain; Headache; Health; Hemato-Encephalic Barrier; Homeostasis; Hormonal; Hormones; Hydrops; Hydrostatic Pressure; Hypertension; Hypertensive Encephalopathy; Impairment; In Vitro; Intracranial Edema; Life; Measurement; Measures; Mediating; Methods and Techniques; Methods, Other; Microbeads; Microspheres; Modeling; Nausea; Nervous System, Brain; Neurologic; Neurological; Occluding Junctions; Organ; PGF; PGF gene; PIFG (factor); PLGF-2; Patients; Permeability; Physiological Homeostasis; PlGF; PlGF protein; Placental Growth Factor; Placental Growth Factor Gene; Pre-Eclampsia; Preeclampsia; Pregnancy; Pregnancy Complications; Pressure; Pressure- physical agent; Production; Property; Property, LOINC Axis 2; Proteinuria-Edema-Hypertension Gestosis; Relaxin; Resistance; Role; Structure; Structure of arteriole; Structure of venule; Techniques; Therapeutic Hormone; Tight Junctions; Time; Toxemias, Pregnancy; Transmission; Unconscious; Unconscious State; Unconsciousness; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular remodeling; Venules; Visual; Vomiting; Woman; Zonula Occludens; arteriole; cerebral blood flow; cerebral circulation; cerebrocirculation; cerebrovascular; clinical relevance; clinically relevant; experiment; experimental research; experimental study; fetal; hemodynamics; hyperpiesia; hyperpiesis; hypertensive disease; in vitro Model; in vivo; in vivo Model; lucifer yellow; medical complication; membrane permeability; neuroimaging; novel; placenta growth factor; placenta growth factor 1, human; pregnancy hypertension; pregnancy toxemia/hypertension; pregnant; pressure; product placenta growth factor; public health relevance; research study; resistant; response; social role; transmission process; venule; wet brain",Cerebrovascular changes in pregnancy and hypertension, Eclampsia is a leading cause of maternal death world-wide. These studies investigate underlying mechanisms by which pregnancy and hypertension during pregnancy affect the cerebral circulation in ways that promote the neurologic complications of eclampsia. This understanding is crucial to effective management and treatment of this devastating condition.,45940,HM,Hypertension and Microcirculation Study Section,,6,325927,
7779975,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS046606-04,,NINDS:364448;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,ANESTHESIOLOGY,07,800772139,US,TX,770304009,UNIVERSITY OF TEXAS MD ANDERSON CAN CTR,"DOUGHERTY, PATRICK M;",1889878;,5R01NS046606,02/15/2007,01/31/2012,"(SP-4-2)-Diamminedichloroplatinum; 2,6-Dioxo-3-phthalimidopiperidine; 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-; 22-Oxovincaleukoblastine; 3-Phthalimidoglutarimide; Abbreviations; Accounting; Active Follow-up; Affect; Alpha-Phthalimidoglutarimide; American; Animals; Anzatax; Asotax; Axonal Transport; Axoplasmic Transport; Back; Behavioral; Blood (Leukemia); Blood Serum; Bristaxol; CDDP; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Patient; Cancer Survivor; Cancer Treatment; Cancer of Breast; Cancers; Cells; Cis-diammine-dichloroplatinum; Cis-diamminedichloridoplatinum; Cis-diamminedichloro Platinum (II); Cis-dichloroammine Platinum (II); Cis-platinous Diamine Dichloride; Cis-platinum II; Cis-platinum II Diamine Dichloride; Cisplatin; Cisplatina; Cisplatinum; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Complement; Complement Proteins; Cysplatyna; DDP; DNA; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Development; Dichlorodiammineplatinum; Disease; Disorder; Distress; Dorsal Root Ganglia; Dorsum; Dose; Dose-Limiting; Drops; Drug usage; Drugs; ELISA; Effectiveness; Enzyme-Linked Immunosorbent Assay; Fiber; Follow-Up Studies; Followup Studies; GM-CSF; GMCSF; Ganglia, Spinal; Generations; Glia; Glial Cells; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; HDNF; Hand; High Dose Chemotherapy; Histamine-Producing Cell-Stimulating Factor; Human; Human, General; Hyperalgesia; Hyperalgesic Sensations; IFN; IGF; Immune; Immunoglobulin Enhancer-Binding Protein; Impairment; In Vitro; Individual; Inflammatory; Insulin-Like Growth Factors; Interferons; Interleukins; Investigators; Kineret; Kolliker's reticulum; LPS; Leukemias, General; Leurocristine; Lipopolysaccharides; Literature; Loss of Sensation; Lung; Lymphocyte; Lymphocytic; Malignant Cell; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Measures; Mechanics; Medication; Medulla Spinalis; Micro-tubule; Microtubules; Minocycline; Modeling; Molecular; Molgramostin; Monocyte Chemoattractant Proteins; Monocyte Chemotactic Proteins; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; NF-kB; NF-kappa B; NF-kappaB; NFKB; NGF-2; NRVS-SYS; NT3; NT3 (neurotropin 3); NTF3; Nerve; Nerve Cells; Nerve Endings; Nerve Growth Factor 2; Nerve Growth Factors; Nerve Unit; Nervous; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neuronotrophic Factors; Neurons; Neuropathy; Neurophysiology - biologic function; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophin 3; Neurotrophins; Non-neuronal cell; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Numbness; PROV; Paclitaxel; Paclitaxel (Taxol); Pain; Painful; Pathogenesis; Patients; Peyrone's Chloride; Peyrone's Salt; Pharmaceutic Preparations; Pharmaceutical Preparations; Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-; Physical Health Services / Rehabilitation; Platinum Diamminodichloride; Platinum, Diaminedichloro-, cis- (8CI); Platinum, diamminedichloro-, (SP-4-2)-; Play; Praxel; Prevention; Production; Productivity; Provider; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Publishing; QOL; Quality of life; Rat; Rattus; Refractory; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research Personnel; Researchers; Respiratory System, Lung; Role; Sedalis; Sensory; Serum; Skin; Somatomedins; Source; Spinal; Spinal Cord; Spinal Ganglia; Sulfation Factor; Symptoms; TC-GM-CSF; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; TXT; Taxol; Taxol (Old NSC); Taxol A; Taxol Konzentrat; Testing; Text; Thalidomide; Therapeutic Intervention; Time; Transcription Factor NF-kB; Tumor Burden; Tumor Load; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Tumor-Cell Human GM Colony-Stimulating Factor; VCR; Vincaleukoblastine, 22-oxo-; Vincristine; Vincrystine; animal data; anticancer therapy; base; cancer care; cancer cell; cancer therapy; cell type; chemotherapy; chemotherapy induced neuropathy; cis dichlorodiammineplatinum; cis platinum compound; cis-Diaminedichloroplatinum; cis-Diamminedichloroplatinum; cis-Diamminedichloroplatinum(II); cis-Dichlorodiammineplatinum(II); cis-Platinum; clinical data repository; clinical data warehouse; clinical investigation; cytokine; data repository; design; designing; disease/disorder; dorsal horn; dorsal root ganglion; drug use; drug/agent; experiment; experimental research; experimental study; follow-up; granulocyte macrophage colony stimulating factor; hippocampus derived neurotrophic factor; hyperalgia; improved; in vivo; indexing; inflammatory pain; insulinlike growth factor; intervention therapy; kappa B Enhancer Binding Protein; leukemia; lymph cell; malignancy; malignant breast neoplasm; neoplasm/cancer; nerve cement; neural function; neuronal; neuropathic; neuropathic pain; novel; nuclear factor kappa beta; oxovincaleukoblastine; painful neuropathy; prevent; preventing; psycho-physiological; pulmonary; rehabilitative; relational database; research study; response; social role; species difference; theories; tumor; tumor necrosis factor (unspecified); unspecified interleukin; volunteer",Mechanisms of Cancer Therapy-Induced Pain,,46606,SCS,Somatosensory and Chemosensory Systems Study Section,,4,364448,
7760958,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS047188-04,,NINDS:330366;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,PATHOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"BONNI, AZAD ;",2114199;,5R01NS047188,02/01/2007,01/31/2011,"Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Apoptosis; Apoptosis Pathway; Apoptotic; Biological; Brain; Brain Diseases; Brain Disorders; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Division Cycle; Cell Signaling; Cerebellar Cortex; Cerebellar cortex structure; Cerebellum; Common Rat Strains; Cytoplasmic Granules; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; EC 2.7; Encephalon; Encephalon Diseases; Encephalons; Foundations; Goals; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigators; Kinases; Lead; Light; Location; Mammals, Rats; Measures; Methods; Mitotic; Molecular; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neurons; Pathogenesis; Pathway interactions; Pb element; Phosphotransferases; Photoradiation; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rat; Rattus; Research; Research Personnel; Researchers; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Testing; Transphosphorylases; apoptosis of neuronal cells; base; biological signal transduction; dementia of the Alzheimer type; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; granule; heavy metal Pb; heavy metal lead; in vivo; insight; loss of function; neurodegenerative illness; neuron apoptosis; neuron cell death; neuron development; neuron loss; neuronal; neuronal apoptosis; neuronal cell death; neuronal loss; neuronal survival; novel; pathway; postnatal; primary degenerative dementia; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; research study; senile dementia of the Alzheimer type; social role; transcription factor",Cell Cycle Regulation of Neuronal Apoptosis,,47188,ZRG1,Special Emphasis Panel,,4,330366,
7760119,R01,NS,5,,02/01/2010,01/31/2011,PAR-07-235,5R01NS047293-06,,NINDS:262009;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"MAKEIG, SCOTT ;",1912740;,5R01NS047293,12/01/2003,01/31/2013,"Analysis, Data; Archives; Bio-Informatics; Bioinformatics; Brain; Brain imaging; Clinical; Code; Coding System; Collaborations; Communities; Community Developments; Complex; Computational Biology; Computer Programs; Computer software; Data; Data Analyses; Data Collection; Data Set; Dataset; Development; Developments, Community; Diagnostic; Documentation; EEG; Educational workshop; Electroencephalography; Electromagnetic; Electromagnetics; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Environment; Event-Related Potentials; Eye; Eyeball; Frequencies (time pattern); Frequency; Functional Imaging; Generalized Growth; Grant; Graphical interface; Growth; Head; Human; Human, General; Image; Imagery; Individual; Investigators; Laboratories; Lead; Libraries; MR Imaging; MR Tomography; MRI; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetoencephalography; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Manuals; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Modeling; Monitor; Motion; NIH; NMR Imaging; NMR Tomography; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, Brain; Neurology; Neurophysiology / Electrophysiology; Nuclear Magnetic Resonance Imaging; On-Line Systems; Online Systems; Pb element; Physiologic; Physiologic Imaging; Physiological; Plug-in; Process; Programs (PT); Programs [Publication Type]; Psychiatry; Publications; Publishing; Reading; Research; Research Personnel; Research Resources; Researchers; Resources; Running; Scalp; Scalp structure; Scientific Publication; Software; Source; Speed; Speed (motion); Stream; Structure; Surface; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Training; United States National Institutes of Health; Visualization; Workshop; Writing; Zeugmatography; base; brain visualization; computer program/software; computerized data processing; computing resources; data processing; design; designing; develop software; developing computer software; event related potential; experience; graphic user interface; graphical user interface; heavy metal Pb; heavy metal lead; imaging; imaging modality; improved; independent component analysis; interoperability; online computer; ontogeny; open source; parallel processing; programs; response; sharing data; signal processing; software development; supercomputer; tool; web based; wiki",EEGLAB: Software for Analysis of Human Brain Dynamics,,47293,ZRG1,Special Emphasis Panel,,6,262009,
7760560,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS047357-07,,NINDS:310768;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DAYTON,UNITED STATES,OTHER BASIC SCIENCES,07,047814256,US,OH,45435,WRIGHT STATE UNIVERSITY,"ALVAREZ, FRANCISCO J;",1905415;,5R01NS047357,12/01/2003,01/31/2013,"0-6 weeks old; 21+ years old; Adult; Axon; Birth; Connector Neuron; Date of birth; Development; Embryo; Embryonic; Human, Adult; Individual; Infant, Newborn; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Mediating; Medulla Spinalis; Motor; Names; Nature; Neurologic; Neurological; Newborn Infant; Newborns; Output; Parturition; Phase; Principal Investigator; Programs (PT); Programs [Publication Type]; Reflex; Reflex action; Renshaw Cell; Research; Specific qualifier value; Specified; Spinal; Spinal Cord; Synapses; Synaptic; Work; adult human (21+); cell type; insight; motor deficit; newborn human (0-6 weeks); programs",Development of synaptic inputs on spinal interneurons,,47357,ZRG1,Special Emphasis Panel,,7,310768,
7751828,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS047578-05,,NINDS:256953;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"BROWN, MELISSA ANN;",1905964;,5R01NS047578,01/01/2006,12/31/2010,"1H-Imidazole-4-ethanamine; ATGN; Affect; Animals; Antigenic Determinants; Antigens; Autoimmune; Autoimmune Process; B blood cells; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cells; B-Lymphocytes; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Basophilic Histiocyte; Basophils, Tissue; Binding Determinants; Binetrakin; Blood - brain barrier anatomy; Blood Vessels; Blood-Brain Barrier; Body Tissues; Bone Marrow; Breeding; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; CD154; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD40L; CD40LG; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; Cell Function; Cell Process; Cell Surface Proteins; Cell physiology; Cells; Cells, CD4; Cellular Function; Cellular Physiology; Cellular Process; Cytofluorometry, Flow; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytokines, Chemotactic; Dendritic Cells; Diathesis; Disease; Disease susceptibility; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Epitopes; Esteroproteases; Event; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Face; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Frequencies (time pattern); Frequency; Generations; Genes; Hemato-Encephalic Barrier; Histamine; Histamine Liberation; Histamine Release; Homing; Homologous Chemotactic Cytokines; IL-10; IL-4; IL10; IL10A; IL4; IL4 Protein; Immune Function, Cellular; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Inflammatory; Intercrines; Interleukin 10 Precursor; Interleukin-10; Interleukin-4; Interleukin-4 Precursor; Investigators; LYT3; Lead; Little's Disease; Lymph node proper; Lymphocyte; Lymphocyte Stimulatory Factor 1; Lymphocytic; Lymphoid; MCGF-2; MOG glycoprotein; MS (Multiple Sclerosis); Mammals, Mice; Marrow Mast Cell; Mast Cell Growth Factor-2; Mediator; Mediator of Activation; Mediator of activation protein; Melissa; Methods; Mice; Microfluorometry, Flow; Modeling; Mouse Strains; Multiple Sclerosis; Murine; Mus; Myelin; Myelin Sheath; Myeloencephalitis; Nerve; Nervous; Organ; Outcome; Pb element; Peptidases; Peptide Hydrolases; Phase; Phenotype; Play; Population; Predisposition; Printing; Procedures; Production; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteins, Cell Surface; Proteolytic Enzymes; Pulmonary Body System; Pulmonary Organ System; R01 Mechanism; R01 Program; RPG; Receptor Protein; Regulation; Relapse; Relative; Relative (related person); Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Respiratory System; Respiratory system (all sites); Respiratory tract structure; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Spleen; Rodent Model; Role; SIS cytokines; SJL Mouse; Sclerosis, Disseminated; Secondary to; Sensitization, Immunologic; Sensitization, Immunological; Severities; Site; Skin; Spastic Diplegia; Spastic Diplegias; Spleen; Staging; Study models; Subcellular Process; Susceptibility; Syndrome; T cell regulation; T-Cell Activation; T-Cell Growth Factor 2; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; TNFSF5; TNFSF5 gene; TRAP Gene; Testing; Thymus-Dependent Lymphocytes; Tissues; Tracts, Respiratory; Transgenic Organisms; Veiled Cells; allergic response; autoimmune encephalomyelitis; autoreactive T cell; base; cerebral spastic infantile paralysis; chemoattractant cytokine; chemokine; cytokine; disease/disorder; disease/disorder proneness/risk; facial; flow cytophotometry; heavy metal Pb; heavy metal lead; helper T cell; immune function; immunogen; insular sclerosis; liability to disease; lymph cell; lymph gland; lymph nodes; macrophage; mast cell; mastocyte; migration; myelin oligodendrocyte glycoprotein; oligodendrocyte-myelin glycoprotein; programs; receptor; reconstitute; reconstitution; respiratory tract; response; restoration; social role; thymus derived lymphocyte; trafficking; transgenic; vascular",Mechanisms of mast cell influence on EAE disease course,,47578,HAI,"Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section",,5,256953,
7767663,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS047603-06,,NINDS:559283;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CINCINNATI,UNITED STATES,ENGINEERING (ALL TYPES),01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"HOLLAND, CHRISTY K.;",2429651;,5R01NS047603,07/01/2004,01/31/2013,"Acoustic; Acoustics; Actins; Acute; Adjuvant; Adjuvant Therapy; After Care; After-Treatment; Aftercare; Alteplase; Animal Model; Animal Models and Related Studies; Antithrombic Drugs; Antithrombotic Agents; Apoplexy; Arteries; Bleeding; Blood Clot; Blood Clotting; Blood Vessels; Blood coagulation; Brain; Brain Hemorrhage, Cerebral; Brain hemorrhage; CLDN1; Caring; Carotid Arteries; Cause of Death; Cerebral Hemorrhage; Cerebral Parenchymal Hemorrhage; Cerebral Stroke; Cerebral hemisphere hemorrhage; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Clotting; Coagulation; Coagulation Process; Contrast Agent; Contrast Drugs; Contrast Media; Cytolysis; Data; Death; Definity; Detection; Development; Diagnosis, Ultrasound; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Echography; Echotomography; Elements; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelial Cells; Endothelium, Vascular; Endothelium-Derived Relaxing Factor; Event; Extravasation; FDA approved; Family suidae; Fibrinolytic Agents; Fibrinolytic Drugs; Fibrinolytic Therapy; Forecast of outcome; Gases; Generations; Goals; Health Care Costs; Health Costs; Healthcare Costs; Hematoma; Hemorrhage; Hemorrhage, Cerebrum; Human; Human, General; In Vitro; Infusion; Infusion procedures; Intracerebral Hemorrhage; Intracranial Hemorrhages; Investigation; Ischemia; Ischemic Stroke; Label; Laboratories; Leakage; Leiomyocyte; Liposomal; Liposomes; Lysis; Man (Taxonomy); Man, Modern; Mechanics; Medical Imaging, Ultrasound; Medication; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; Mononitrogen Monoxide; Myocytes, Smooth Muscle; Nervous System, Brain; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Occluding Junctions; Optics; PLAT; Pathologic; Patients; Penetration; Perfusion; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic pulse; Pigs; Productivity; Prognosis; Proteins; Pulse; Radiopaque Media; Recombinant Tissue Plasminogen Activator; Risk; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Spillage; Staging; Stroke; Strokes, Acute; Suidae; Surface; Survivors; Swine; System; System, LOINC Axis 4; T-Plasminogen Activator; TTPA; Techniques; Testing; Therapeutic; Thrombolysis, Therapeutic; Thrombolytic Agents; Thrombolytic Drugs; Thrombolytic Therapy; Thrombus; Tight Junctions; Tissue Activator D-44; Tissue Plasminogen Activator; Tissue-Type Plasminogen Activator; Transducers; Treatment Period; Ultrasonic; Ultrasonic Imaging; Ultrasonics; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Vascular Accident, Brain; Vascular Endothelium; WHBLOOD; Whole Blood; Zonula Occludens; acute stroke; blood loss; brain attack; brain tissue; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; claudin-1; claudin-1 protein; design; designing; detector; diagnostic ultrasound; disability; dosage; drug efficacy; drug/agent; endothelial cell derived relaxing factor; gastrointestinal; gene product; hemorrhagic stroke; improved; in vitro Model; in vivo; insight; life time cost; lifetime cost; model organism; new approaches; novel approaches; novel strategies; novel strategy; outcome forecast; porcine; public health relevance; restoration; sonogram; sonography; sound measurement; stroke; stroke therapy; suid; t-PA; thrombolysis; time use; tool; treatment days; treatment duration; ultrasound; ultrasound imaging; ultrasound scanning; vascular",Ultrasound-Assisted Thrombolysis for Stroke Therapy," Project Narrative Our long-term objective is to develop a transcranial, ultrasound-enhanced thrombolysis system that minimizes the risk of intracranial hemorrhage, increases the number of stroke survivors, improves long-term prognosis, and reduces health care costs. The development of the agents and techniques listed in this proposal would have far reaching implications in improving directed therapeutic treatment of stroke.",47603,BMIT,Biomedical Imaging Technology Study Section,,6,559283,
7760168,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS047710-07,,NINDS:356315;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"MA, QIUFU ;",6416870;,5R01NS047710,01/01/2004,01/31/2014,"Affect; Afferent Neurons; Alleles; Allelomorphs; Behavior Control; Behavioral; Behavioral Manipulation; Brain; Data; Defect; Depression; Development; Disease Outcome; Dorsal; Dorsal Horn Cells; Encephalon; Encephalons; Exhibits; Funding; Gene Expression; Gene Transcription; Genetic; Genetic Algorithm; Genetic Programming; Genetic Transcription; Genome; Glutamates; Goals; Homeo Boxes; Homeobox; Knock-out; Knockout; Knockout Mice; L-Glutamate; Label; Lead; Locomotion; Mammals, Mice; Maps; Mediating; Medical; Medulla Spinalis; Mental Depression; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Molecular; Murine; Mus; NRVS-SYS; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuronal Transmission; Neurons; Neurons, Afferent; Neurons, Dorsal Horn; Neurons, Posterior Horn; Neurons, Sensory; Neurotransmitters; Nociception; Nociceptors; Null Mouse; Pain; Pain Control; Pain Therapy; Pain management; Painful; Pattern; Pb element; Peptides; Perception; Phenotype; Play; Population; Posterior Horn Cells; Prevention; Process; Programs (PT); Programs [Publication Type]; RNA Expression; Research; Role; Sensory Cell Afferent Neuron; Spinal; Spinal Cord; Staging; Techniques; Testing; Thalamic Nuclei; Time; Transcription; Transcription, Genetic; Work; adult animal; base; behavioral control; chronic pain; chronic painful condition; dorsal horn; excitatory neuron; heavy metal Pb; heavy metal lead; human disease; innervation; insight; mature animal; molecular phenotype; nerve supply; neural circuit; neural circuitry; neuronal; neurotransmission; new therapeutic target; nociceptive; novel; pain behavior; programs; public health relevance; social role; tool; transcription factor",Molecular control of spinal relay sensory neuron phenoypes and pain behaviors," b. Project Narrative Pain management remains a major medical problem in a variety of human diseases. Chronic pain, moreover, is associated with worse disease outcome and depression. In the fullness of time, the work may allow us to determine whether the Tlx3-mediated core transcriptional program is a valid and novel therapeutic target for pain management.",47710,NCF,Neurogenesis and Cell Fate Study Section,,7,356315,
7766942,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS047715-06,,NINDS:384318;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,BIOPHYSICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"GOODMAN, MIRIAM B;",1935408;,5R01NS047715,12/01/2003,02/28/2013,"Actin-Binding Protein; Affect; Alleles; Allelomorphs; Amiloride; Animals; Antimorphic mutation; Behavioral; Biophysics; Bladder Control; Blood Pressure; Body Surface; Boxing; C elegans; C.elegans; Caenorhabditis elegans; Candidate Disease Gene; Candidate Gene; Cell Function; Cell Process; Cell membrane; Cell physiology; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Chronic Disease; Chronic Illness; Complement; Complement Proteins; Complex; Conserved Sequence; Corpuscula Lamellosa; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Dendrites; Devices; Diabetes Mellitus; Diagnostic; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dysfunction; ENaC; ENaC (epithelial Na+ channel); Electron Microscopy; Electrophysiology; Electrophysiology (science); Elements; Esthesia; Event; Figs; Figs - dietary; Functional disorder; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic analyses; Genetic defect; Health Care Costs; Health Costs; Healthcare Costs; Ion Channel; Ion Channel Protein; Ionic Channels; Lamellated Corpuscle; Lateral; Lead; Learning; Mammalia; Mammals; Mammals, General; Measures; Mechanics; Mechanoreceptors; Mediating; Membrane; Membrane Channels; Micro-tubule; Microtubule Bundle; Microtubules; Molecular; Msec; Mutation; Nematoda; Nematodes; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Pacinian Corpuscles; Pb element; Physiopathology; Plants; Plants, General; Plasma Membrane; Play; Point Mutation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Pressure; Pressure- physical agent; Proteins; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Ramp; Receptor Protein; Recombinants; Research; Role; Sensation; Sensory; Sequence-Specific Posttranscriptional Gene Silencing; Skin; Stimulus; Subcellular Process; TM Domain; TXT; Testing; Text; Touch; Touch sensation; Transmembrane Domain; Transmembrane Region; Tubulin; Vater's Corpuscle; Vater-Pacini Corpuscle; Vibration; Vibration - physical agent; Walking; Work; Yeasts; age dependent; age related; base; bladder continence; chronic disease/disorder; chronic disorder; cost; cross-link; crosslink; diabetes; disease/disorder; epithelial Na+ channel; experiment; experimental research; experimental study; gene product; genetic analysis; genome mutation; heavy metal Pb; heavy metal lead; improved; in vivo; insight; interest; intracellular skeleton; loss of function; member; membrane structure; micturition control; millisecond; mutant; neuronal; normal aging; patch clamp; pathophysiology; plasmalemma; pore forming protein; porin; pressure; public health relevance; receptor; research study; response; roundworm; social role; tool; touch panel; touch screen; touch screen panel; touchscreen; touchscreen panel; urinary continence; urinary control; urination control; vibration",Molecular Basis of Sensory Transduction in C. elegans,"  The senses of touch and vibration are compromised in normal aging and by chronic diseases such as diabetes. Recent estimates suggest that the health costs due to diabetes- and age-related dysfunction of touch and vibration sensation are more than $28 billion annually. This proposal seeks to improve understanding of touch sensation by studying the roundworm C. elegans, a simple animal that whose sense of touch is better studied than our own. What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation.",47715,BPNS,Biophysics of Neural Systems Study Section,,6,384318,
7758250,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS048085-05,,NINDS:268546;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,PHARMACOLOGY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"PAK, DANIEL T;",6410684;,5R01NS048085,02/15/2006,01/31/2011,"APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Address; Affect; Amentia; Ammon Horn; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; COS Cells; COS-1; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cellular Migration; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cornu Ammonis; Data; Dementia; Dendritic Spines; Development; Disturbance in cognition; Drosophila polo protein; EC 2.7; Equilibrium; Event; Excision; Excitatory Synapse; Extirpation; Family; Generalized Growth; Growth; HMG-20; High Mobility Protein 20; Hippocampus; Hippocampus (Brain); Human; Human, General; Impaired cognition; In Vitro; Intracellular Communication and Signaling; Kinases; Knowledge; Learning; Life; Man (Taxonomy); Man, Modern; Memory; Methods; Modeling; Molecular; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Morphology; Motility; Motility, Cellular; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurobiology; Neurocyte; Neuron Degeneration; Neurons; Pathway interactions; Peptides; Phosphorylation; Phosphorylation Site; Phosphotransferases; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Potentials, Synaptic; Preparation; Procedures; Process; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Proteins; Public Health; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Regulation; Removal; Role; SNK gene product, enzyme; Screening procedure; Sequence-Specific Posttranscriptional Gene Silencing; Serine Kinase; Serine-Threonine Kinases; Serine/Threonine-Protein Kinase SNK; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Small G-Proteins; Small GTPases; Spinal Column; Spine; Structure; Surgical Removal; Synapses; Synaptic; Synaptic Potentials; Synaptic plasticity; Synaptosomes; Testing; Threonine Kinase; Tissue Growth; Transphosphorylases; Ubiquitin; Vertebral column; Viral; backbone; balance; balance function; base; biological signal transduction; cell motility; clinical significance; clinically significant; cognitive dysfunction; cognitive loss; cognitively impaired; dendrite spine; density; experiment; experimental research; experimental study; gene product; hippocampal; insight; morphogens; neocortical; neural degeneration; neurobiological; neurodegeneration; neurodegenerative dementia; neuron development; neuronal; neuronal degeneration; novel; ontogeny; overexpression; pathway; polo kinase; polo protein; polo protein, Drosophila; postsynaptic; public health medicine (field); research study; resection; screening; screenings; serum-inducible kinase; social role; synapse formation; synaptogenesis; synaptoneurosome",Molecular mechanisms of synapse lose by polo kinases,,48085,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,5,268546,
7752476,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS048557-05,,NINDS:272525;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,NEUROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"CRINO, PETER B;",1993663;,5R01NS048557,01/01/2006,12/31/2010,"0-11 years old; Affect; Allelic Loss; Antibodies; Assay; Astrocytes; Astrocytus; Astroglia; BZS; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain region; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Candidate Disease Gene; Candidate Gene; Catenin, Beta-1; Cell Communication and Signaling; Cell Count; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Number; Cell Proliferation; Cell Signaling; Cell Size; Cell surface; Cells; Cellular Proliferation; Child; Child Youth; Children (0-21); Chimp; Chimpanzee; Closure by Ligation; Complementary DNA; Computer Assisted; Cortical Dysplasia; Cortical Malformation; Cyclins; Cytomegalic Cell; DNA Alteration; DNA mutation; DNA, Complementary; Data; Development; Disease; Disorder; EC 2.7; Encephalon; Encephalons; Event; Exhibits; Exons; Extracellular Signal-Regulated Kinase Gene; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Gene Alteration; Gene Components; Gene Deletion; Gene Expression; Gene Mutation; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Genetic mutation; Genome; Genomics; Glycogen Synthase Kinases; Goals; High Throughput Assay; Human; Human, Child; Human, General; IGF-1; IGF-I; IGF-I-SmC; IGF1; Individual; Insertion Mutation; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Intracellular Communication and Signaling; Intracellular Second Messengers; Intractable Epilepsy; Isoforms; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; Kinases; Label; Lead; Ligation; Loss of Heterozygosity; MAP Kinase 8; MAP Kinase 8 Gene; MAP Kinase Gene; MAPK; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MHAM; MMAC1; Man (Taxonomy); Man, Modern; Membrane; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Gene; Molecular; Morphology; Mutation; Mutation Analysis; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; PRKM8; PRO2286; PTEN; PTEN gene; PTEN1; Pan; Pan Genus; Pan Species; Pathogenesis; Pathway interactions; Pb element; Phosphatase and Tensin Homolog; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphorylation; Phosphotransferases; Play; Point Mutation; Polymorphism, Single Base; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; RAFT1 protein, human; RAPT1 protein, human; RNA Expression; Rapamycin Target Protein; Receptor Protein; Research Specimen; Ribosomal Protein S6; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; SNP; SNPs; Second Messenger Systems; Second Messengers; Sequence Alteration; Signal Transduction; Signal Transduction Systems; Signaling; Single Nucleotide Polymorphism; Somatic Mutation; Somatomedin C; Specimen; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Testing; Tissues; Transcription; Transcription Activation; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription, Genetic; Transcriptional Activation; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transphosphorylases; Up-Regulation; beta catenin; biological signal transduction; brain tissue; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; cDNA; cDNA Arrays; cDNA Microarray; children; computer aided; disease/disorder; experiment; experimental research; experimental study; gene deletion mutation; gene function; gene product; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; high throughput screening; human FRAP1 protein; in vitro Assay; insight; jun-NH2-Terminal Kinase; loss of function mutation; mTOR; malformation; membrane structure; neuronal; pathway; programs; protein expression; rapamycin and FKBP12 target 1 protein, human; receptor; research study; second messenger; selective expression; selectively expressed; social role; stress-activated protein kinase 1; youngster",Molecular pathogenesis of focal cortical dysplasias,,48557,DBD,Developmental Brain Disorders Study Section,,5,272525,
7760545,R01,NS,5,,02/01/2010,01/31/2011,PA-07-089,5R01NS048837-07,,NINDS:395504;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,FORT WORTH,UNITED STATES,ANATOMY/CELL BIOLOGY,12,110091808,US,TX,761072699,UNIVERSITY OF NORTH TEXAS HLTH SCI CTR,"GHORPADE, ANUJA ;",6064975;,5R01NS048837,02/01/2005,01/31/2014,"8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-; AIDS; AIDS Dementia; AIDS Dementia Complex; AIDS Virus; AIDS with dementia; AIDS-related dementia; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immune Deficiency Syndrome related dementia; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Adverse effects; Affect; Age; Amentia; Animal growth regulators, transforming growth factors; Antiretroviral Therapy, Highly Active; Apoptotic; Area; Arts; Assay; Astrocytes; Astrocytus; Astroglia; Astroprotein; Autoregulation; BDNF; Band Shift Mobility Assay; Bandshift Mobility Assay; Behavioral; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Brain-Derived Neurotrophic Factor; CCAAT displacement protein; CDP protein; CLG; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Central Nervous System; Chronic; Clinic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cognitive; Collaborations; Complication; Cues; Cut homeodomain protein; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Development; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drugs; Dysfunction; Edodekin Alfa; Electrophoretic Mobility Shift Assay; Elements; Encapsulated; Encephalon; Encephalons; Exhibits; Fibroblast Collagenase; Foundations; Functional disorder; Funding; Future; GFA-Protein; GFAC; GFAP; Gene Expression; Glial Fibrillary Acid Protein; Glial Fibrillary Acidic Protein; Glial Intermediate Filament Protein; Glutamates; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HAART; HIV; HIV Dementia; HIV associated dementia; HIV-1; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-I; HIV-related dementia; HIV1; HTLV-III; Hand; Highly Active Antiretroviral Therapy; Homeostasis; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; IL-12; IL12; INFLM; Immune; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunologic, Luciferase; In Vitro; In element; Indium; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Interleukin-12; Interstitial Collagenase; Intracellular Communication and Signaling; Intravenous; Investigation; L-Glutamate; LAV-HTLV-III; Lead; Link; Luciferases; Lymphadenopathy-Associated Virus; MGC34632; MMP-1; MMP-1Fibroblast Collagenase; MMP1; MMPs; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-1; Matrix Metalloproteinases; Mediating; Medication; Metallopeptidases; Metalloproteases; Metalloproteinases; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Mice; Mobility Shift Assay; Molecular; Molecular Interaction; Motor; Murine; Mus; NKSF; NOD/SCID mouse; Natural Killer Cell Stimulatory Factor; Neoplasm Metastasis; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocognitive; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neurons; Neurotoxins; Organ; Overexpression; PHEMX; PHEMX Protein; PHEMX protein, human; Pan-Hematopoietic Expression Protein; Pathogenesis; Pathway interactions; Patients; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Physiopathology; Plasmids; Play; Polymers; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Protein Overexpression; Proteins; Receptor Protein; Receptor Signaling; Regulation; Reporter; Repression; Research; Role; Scheme; Secondary Neoplasm; Secondary Tumor; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Protein; Site; Stability, mRNA; Staurosporine; Stimulus; System; System, LOINC Axis 4; TIMP-1; TSSC6; TSSC6 protein, human; Tetraspanin; Therapeutic; Therapeutic Exploratory Study; Time; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinases; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transforming Growth Factors; Treatment Side Effects; Tumor Cell Migration; Tumor Growth Factors; Tumor-Suppressing STF 6 Protein; Two Hybrid; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Viral; Virus; Virus-HIV; Viruses, General; Withdrawal; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; angiogenesis; anti-retroviral therapy, highly active; astrogliosis; base; biological signal transduction; brain tissue; cancer metastasis; clinical data repository; clinical data warehouse; data repository; disease/disorder; drug/agent; experience; experiment; experimental research; experimental study; extracellular; gel shift assay; gene product; heavy metal Pb; heavy metal lead; human PHEMX protein; human T cell leukemia virus III; human T lymphotropic virus III; in vivo; inhibitor; inhibitor/antagonist; injury and repair; insight; mRNA Stability; macrophage; metalloproteinase (general); mutant; nano formulation; nano medicine; nano particle; nanoformulation; nanomedicine; nanoparticle; necrocytosis; neural mechanism; neurodegenerative illness; neuroinflammation; neuromechanism; neuron toxicity; neuronal; neuronal survival; neuronal toxicity; neuroprotection; neurotoxic; neurotoxicant; neurotoxicity; new therapeutic target; novel; overexpress; pan-hematopoietic expression protein, human; pathophysiology; pathway; plasmid DNA; poly(D,L-lactide-co-glycolide); protein activation; protein expression; public health relevance; receptor; receptor-mediated signaling; regenerative; relational database; research study; response; side effect; social role; therapy adverse effect; translational approach; treatment adverse effect; tumor growth; tumor suppressing subtransferable candidate 6 protein, human; yeast two hybrid system","Neuronal survival, HIV-1 and Astrocyte TIMP-1"," Relevance: HIV-1-associated dementia (HAD), now referred to as HIV-1-associated neurocognitive disorder, is an important neurological complication of HIV-1 infection and is characterized by cognitive, behavioral and motor dysfunction. An estimated 10-15% of HIV-seropositive (HIV+) patients progress to develop HAD in developed worlds such as the United States, despite the availability of highly active antiretroviral therapy. Reactive astrogliosis, recruitment to and proliferation of astrocytes at the site of injury, is the pathological hallmark of all neuroinflammatory conditions and is observed in areas of inflammation in HAD. How neuroprotective responses of astrocytes are altered in neuroinflammation and contribute to disease is intriguing and is the focus of our and many other recent investigations. Our studies will provide a better understanding of the specific mechanistic contributions of activated astrocytes to HIV-1-neuropathogensis and neuroinflammation.",48837,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,7,395504,
7752479,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS049091-05,,NINDS:316995;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AUSTIN,UNITED STATES,BIOLOGY,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"AGARWALA, SEEMA ;",7849403;,5R01NS049091,01/01/2006,12/31/2010,"Acute; Addictive Behavior; Affinity; Animal Model; Animal Models and Related Studies; Apoplexy; Assay; BCNS; Bioassay; Biologic Assays; Biological Assay; Brachydanio rerio; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Death; Cell Growth in Number; Cell Multiplication; Cell Nucleus; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Complex; Danio rerio; Data; Defect; Development; Electroporation; Encephalon; Encephalons; Erinaceidae; Extremities; Eye; Eyeball; Floor; GCPS; GLI; GLI gene; GLI-Kruppel Family Member 2; GLI-Kruppel Family Member 3; GLI1; GLI1 Gene; GLI2; GLI2 gene; GLI3; GLI3 gene; Gene Expression; Gene Family; Gene Proteins; Genes; Glioma-Associated Oncogene Homolog; Goals; Gx Protein; HPE7; Hedgehogs; Idiopathic Parkinson Disease; In Vitro; Individual; Intracellular Communication and Signaling; Investigators; Knockout Mice; Lateral; Lewy Body Parkinson Disease; Ligands; Limb structure; Limbs; Mammalia; Mammals; Mammals, General; Mammals, Mice; Medulla Spinalis; Mesencephalon; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mid-brain; Midbrain; Midbrain structure; Molecular; Motor; Movement; Murine; Mus; Mutant Strains Mice; NBCCS; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural tube; Neurocyte; Neurons; Non-Trunk; Nucleus; Nucleus Ruber; Null Mouse; PAP-A; PTC; PTC1; PTCH; PTCH gene; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pattern; Pattern Formation; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Primary Parkinsonism; Process; Programs (PT); Programs [Publication Type]; Protein Gene Products; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Red Nucleus; Red nucleus structure; Research Personnel; Researchers; Role; SMO; SMO protein, human; SMOH; SMOH protein, human; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Smoothened; Smoothened Homolog; Source; Specific qualifier value; Specified; Spinal Cord; Stem Cell Development; Stroke; Substantia Nigra; Substantia nigra structure; THP; Testing; Therapeutic; Vascular Accident, Brain; Ventral Tegmental Area; Zebra Danio; Zebra Fish; Zebrafish; base; biological signal transduction; body movement; brain attack; cell fate specification; cell type; cerebral vascular accident; combat; experiment; experimental research; experimental study; gene function; gene interaction; hedgehog signal transduction; hh signal transduction; human SMO protein; in vivo; knock-down; knockout gene; loss of function; model organism; mouse mutant; mutant; necrocytosis; neural; neuronal; ocular motor; ocularmotor; oculomotor; overexpression; pathway; progenitor; programs; protein expression; relating to nervous system; research study; smoothened homolog (Drosophila), human; social role; stroke; transcription factor; ventral tegmentum",Molecular Mechanisms in Vertebrate Midbrain Development,,49091,NCF,Neurogenesis and Cell Fate Study Section,,5,316995,
7761241,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS049310-05,,NINDS:268200;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STONY BROOK,UNITED STATES,PHYSIOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"SOLOMON, IRENE C;",1903976;,5R01NS049310,01/01/2006,12/31/2010,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Algorithms; Aminalon; Aminalone; Area; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Brain Stem; Brainstem; Butanoic acid, 4-amino-; Cell Nucleus; Central Nervous System; Chemoreceptors; Communicating Junction; Connexins; Coupling; Cranial Nerve XII; Cx36 protein; Diaphragm; Diaphragm (Anatomy); Dorsal; Fourier Transform; Frequencies (time pattern); Frequency; GABA; Gap Junction Proteins; Gap Junctions; Generations; Hypoglossal Nerve; Hypoglossal nerve structure; Immunoblotting; In Situ; In Vitro; Isoforms; Label; Low-resistance Junction; Mammals, Mice; Mediating; Mice; Motor; Murine; Mus; Muscle; Muscle Tissue; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, CNS; Neural Cell; Neural Transmission; Neuraxis; Neurocyte; Neurons; Nexus; Nexus Junction; Nucleus; Parvalbumins; Peripheral; Phrenic Nerve; Physiologic; Physiological; Play; Preparation; Protein Isoforms; Protocol; Protocols documentation; Receptor Protein; Research Proposals; Respiratory Diaphragm; Role; Structure of phrenic nerve; Synapses; Synaptic; Synaptic Transmission; System; System, LOINC Axis 4; Time; Tissue Sample; Tissues; Transform, Fourier; Twelfth Cranial Nerve; Uncoupling Agents; Work; connexin 36; connexin 36 protein; connexin36; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; genetic manipulation; in vivo; indexing; inhibitory neuron; motor control; neural control; neural regulation; neuronal; neuroregulation; receptor; research study; respiratory; social role; synapse inhibition; synaptic inhibition; time use",Mechanisms of Fast Oscillations in Motor Discharges,,49310,SMI,Sensorimotor Integration Study Section,,5,268200,
7769839,R01,NS,5,,03/01/2010,02/28/2011,PAS-03-165,5R01NS049409-05,,NINDS:289073;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NEUROSURGERY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"GRILL, RAYMOND J;",1879340;,5R01NS049409,05/01/2006,02/28/2011,"1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-; 21+ years old; 7B4 Antigen; 7B4 protein; Acute; Adherens Junction; Adhering Junction; Adhesive Junction; Adult; Affect; Age; Albumins; Anchoring Junction; Animals; Antiphosphodiesterases; Assay; Astroprotein; Attenuated; Behavioral; Behavioral Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Bleeding; Blood; Blood Plasma; Blood Serum; Blood Vessels; Blood, Cord; Blotting, Western; Body Tissues; Brain Stem; Brainstem; Bruise; CD144 Antigen; CDH5; Cell-Extracellular Matrix; Cerebrospinal Fluid; Chronic; Chronic Phase; Clinic; Common Rat Strains; Contusions; Data; Development; Dextran 70; Dose; Drug usage; Drugs; Dysfunction; ECM; Elements; Endothelial Cells; Environment; Event; Extracellular Matrix; Extravasation; Functional disorder; GFA-Protein; GFAP; Gamma Globulin, 7S; Gene Expression; Generalized Growth; Glial Fibrillary Acid Protein; Glial Fibrillary Acidic Protein; Glial Intermediate Filament Protein; Goals; Growth; HRP; Hair; Harvest; Hemorrhage; Horseradish Peroxidase; Hour; Human, Adult; Hyperalgesia; Hyperalgesic Sensations; Hypoglycemia; INFLM; IgG; Image; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; Immune; Immunoglobulin G; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Injury; Intervention; Intervention Strategies; Investigators; Ischemia; Killings; Leakage; Lesion; Literature; Locomotion; Longitudinal Studies; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rats; Mechanics; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Medulla Spinalis; Methods and Techniques; Methods, Other; Molecular; Molecular Weight; Motor; Myelopathy, Traumatic; NG2 antigen; NG2 proteoglycan; NMR Imaging; NMR Tomography; Names; Natural regeneration; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurologic outcome; Neurological; Neurological Disorders; Neurological outcome; Neurons; Nuclear Magnetic Resonance Imaging; Occluding Junctions; Outcome; Oxpentifylline; PDE; Palsy; Paralysed; Pathology; Pentoxifylline; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phosphodiesterase Antagonists; Phosphodiesterase Inhibitors; Phosphodiesterases; Phosphoric Diester Hydrolase Inhibitors; Physiopathology; Pilot Projects; Plasma; Plegia; Poisons; Pressure; Pressure- physical agent; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-; ROC Analysis; Rat; Rats, Sprague-Dawley; Rattus; Regeneration; Regimen; Reporting; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Rolipram; Rupture; Saline; Saline Solution; Sampling; Sensory; Serum; Serum Proteins; Serum, Plasma; Site; Spillage; Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Sprague-Dawley Rats; Structure; Tactile; Tag; Technics, Imaging; Techniques; Testing; Tight Junctions; Time; Tissue Growth; Tissues; Toxic Chemical; Toxic Substance; Tracer; Trauma; Trental; Umbilical Cord Blood; VE-Cadherin; Vascular Endothelial Cadherin; Vascular Endothelial Cadherin 1; Vascular Permeabilities; Western Blotting; Western Blottings; Western Immunoblotting; Zeugmatography; Zonula Occludens; adult human (21+); allodynia; base; blood loss; cadherin 5; cytokine; design; designing; drug use; drug/agent; experiment; experimental research; experimental study; fetal cord blood; gene product; hyperalgia; hypoglycemic; hypoglycemic episodes; image evaluation; imaging; improved; in vivo; indexing; inhibitor; inhibitor/antagonist; injured; interventional strategy; long-term study; member; nervous system disorder; neural; neurological disease; neuronal; ontogeny; paralysis; paralytic; pathophysiology; phosphoric diester hydrolase; pilot study; poison; pressure; prevent; preventing; programs; protein blotting; reconstitute; reconstitution; regenerate; relating to nervous system; repair; repaired; research study; response; spinal fluid; toxic compound; vascular","Phosphodiesterase-inhibitors, vascular integrity and SCI",,49409,ZRG1,Special Emphasis Panel,,5,289073,
7761230,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS049436-05,,NINDS:305233;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BLOOMINGTON,UNITED STATES,PSYCHOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"PUCE, AINA ;",7855516;,5R01NS049436,08/03/2006,01/31/2011,"Action Potentials; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Apes; Area; Asperger Syndrome; Asperger's Disorder; Attention; Auditory; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bilateral; Binding; Binding (Molecular Function); Biological; Brain; Buccal Cavity; Cavitas Oris; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Cephalic; Cognitive; Communication; Communication Disorders; Communication impairment; Communicative Disorders; Cranial; Cues; Data; Data Collection; Data Set; Dataset; Development; Disease; Disorder; Electrophysiology; Electrophysiology (science); Elements; Emotional; Encephalon; Encephalons; Event-Related Potentials; Exhibits; Face; Facial Expression; Functional Magnetic Resonance Imaging; Future; Gestures; Goals; Head and Neck, Buccal Cavity; Human; Human, General; Impairment; Intracellular Communication and Signaling; Investigation; Investigators; Kanner's Syndrome; Knowledge; Life; Link; Literature; MR Imaging; MR Tomography; MRI; MRI, Functional; Macaca; Macaca mulatta; Macaque; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Mammals, Primates; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Mind; Modality; Modeling; Molecular Interaction; Monkeys; Motion; Mouth; Movement; Msec; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Nuclear Magnetic Resonance Imaging; Oral cavity; Persons; Physiologic; Physiological; Pongidae; Population; Population Process; Population-Level Process; Primates; Procedures; Process; Programs (PT); Programs [Publication Type]; Reading; Relative; Relative (related person); Research; Research Personnel; Researchers; Resolution; Rhesus; Rhesus Macaque; Rhesus Monkey; Scalp; Scalp structure; Schizophrenia; Schizophrenic Disorders; Science of neurophysiology; Signal Transduction; Signal Transduction Systems; Signaling; Sneezing; Sneezings; Social Environment; Source; Stimulus; Structure; Structure of superior temporal sulcus; Study Subject; Subcellular Process; Superior Temporal Sulcus; Techniques; Time; Translating; Translatings; Visual; Work; Zeugmatography; amygdaloid nuclear complex; base; biological signal transduction; body movement; cognitive neuroscience; dementia praecox; disease/disorder; event related potential; experience; fMRI; face expression; facial; frontal cortex; frontal lobe; gaze; great ape; indexing; innovate; innovation; innovative; language translation; mental state; millimeter; millisecond; multisensory; neocortical; neural; neural mechanism; neural model; neuroimaging; neuromechanism; neuronal; neurophysiology; non-human primate; nonhuman primate; programs; relating to nervous system; response; schizophrenic; skills; social; social climate; social cognition; social communication; social context; socioenvironment; theories; vocalization",The neural basis of social cognition,,49436,ZRG1,Special Emphasis Panel,,5,305233,
7748926,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS049476-05,,NINDS:334170;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"WANG, XIAOYING ;",7130064;,5R01NS049476,01/01/2006,12/31/2010,"3-mononitrotyrosine; 3-nitrotyrosine; AIF protein; Active Oxygen; Acute; Affect; Affinity; Apaf-3 protein; Apopain; Apoplexy; Apoptotic; Apoptotic Protease Activating Factor 3; Apoptotic Protease MCH-6; Assay; Attention; Bioassay; Bioenergetic; Bioenergetics; Biologic Assays; Biological Assay; Blotting, Western; Body Tissues; Brain; Brain Hypoxia-Ischemia; CASP-3; CASP3; CASP9 Protein; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Caspase 9, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death Signaling; Cell Death Signaling Process; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Cysteine Protease CPP32; D-Glucose; Data; Death; Dextrose; Diffusion; Dropsy; Dysfunction; Edema; Encephalon; Encephalons; Extravasation; Ferricytochrome c; Ferrocytochrome c; Functional disorder; Globin; Glucose; Glutamates; Histology; Hydrops; Hypoxia; Hypoxia-Ischemia, Brain; Hypoxic; ICE-LAP6; ICE-LAP6 protein; ICE-Like Apoptotic Protease 6; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Nick-End Labeling; In Vitro; Infarction; Intracellular Communication and Signaling; Investigators; Ischemia; L-Glutamate; Lead; Leakage; Life; Lipid Peroxidation; Lytotoxicity; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malonaldehyde; Malondialdehyde; Malonylaldehyde; Malonyldialdehyde; Mammals, Mice; Markers, Surrogate; Mch6 protein; Measurement; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane Potentials; Mice; Mice, Transgenic; Mitochondria; Modeling; Murine; Mus; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic outcome; Neurological outcome; Neuronal Hypoxia; Neurons; Neurotransmitters; Nitrates; Nitrites; Nuclear Magnetic Resonance Imaging; O element; O2 element; Outcome; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen Deficiency; Oxygen Radicals; PARP Cleavage Protease; Pb element; Perfusion; Physiopathology; Pro-Oxidants; Process; Production; Programs (PT); Programs [Publication Type]; Propanedial; RT-PCR; RTPCR; Reactive Nitrogen Species; Reactive Oxygen Species; Recovery of Function; Redox; Reporting; Research Personnel; Researchers; Respiration; Respiratory Chain; Resting Potentials; Reverse Transcriptase Polymerase Chain Reaction; Role; Rotarod Assay; Rotarod Method; Rotarod Performance Test; Rotarod Test; SCA-1; SREBP Cleavage Activity 1; Signal Transduction; Signal Transduction Systems; Signaling; Spillage; Staging; Staining method; Stainings; Stains; Stress; Stroke; Superoxide Anion; Superoxide Radical; Superoxides; Surrogate Markers; TUNEL; Testing; Time; Tissues; Transgenic Mice; Transgenic Organisms; Transmembrane Potentials; Vascular Accident, Brain; Weight; Western Blotting; Western Blottings; Western Immunoblotting; Wild Type Mouse; Yama; Yama protein; Zeugmatography; apoptosis inducing factor; base; biological signal transduction; biomarker; brain attack; caspase-3; caspase-9; cerebral vascular accident; clinical relevance; clinically relevant; complex IV; cysteine protease P32; cytochrome c; cytotoxicity; deprivation; excitotoxicity; experiment; experimental research; experimental study; functional outcomes; functional recovery; heavy metal Pb; heavy metal lead; hypoxia ischemia; improved; in vivo; infarct; insight; mitochondrial; mitochondrial apoptosis-inducing factor; mitochondrial membrane; morris water maze; morris watermaze; neuroglobin; neurological recovery; neuronal; neuroprotection; new therapeutics; next generation therapeutics; nitrotyrosine; novel; novel therapeutics; oxidation reduction reaction; p-Globin; pathophysiology; programs; protective effect; protein blotting; research study; respiratory mechanism; response; reverse transcriptase PCR; social role; stroke; terminal nick end labeling; transgenic",Neuroprotective Mechanisms of Neuroglobin in Stroke,,49476,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,5,334170,
7773510,R01,NS,5,,03/01/2010,02/28/2011,,5R01NS049517-06,,NINDS:349009;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DALLAS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"MEDIN, PAUL M;",8515991;,5R01NS049517,03/15/2006,02/28/2011,"Adverse effects; Affect; Arm; Biological Function; Biological Process; Bone structure of spine; Brain; Cancer Patient; Cancer Radiotherapy; Cancers; Clinical; Clinical Treatment; Common Rat Strains; Data; Dose; Dose-Rate; Encephalon; Encephalons; Family suidae; Guidelines; History; Human; Human, General; Image; Incidence; Individual; Intervention; Intervention Strategies; Intervention Studies; Intracranial Central Nervous System Neoplasms; Intracranial Central Nervous System Tumors; Intracranial Neoplasms; Intracranial Tumor; Intraspinal Neoplasm; Intraspinal Tumor; Knowledge; Lesion; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Tumor; Mammals, Primates; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Methods and Techniques; Methods, Other; Modeling; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Neoplasm Metastasis; Neoplasms; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Pain; Pain-Free; Painful; Palsy; Paralysed; Patients; Pigs; Plegia; Primates; QOL; Quality of life; Radiation; Radiation Sensitivity; Radiation Surgery; Radiation Tolerance; Radiation therapy; Radiosensitivity; Radiosurgery; Radiotherapeutics; Radiotherapy; Rat; Rattus; Recording of previous events; Regimen; Retreatment; Rodent; Rodentia; Rodentias; Secondary Neoplasm; Secondary Tumor; Sensory; Sound; Sound - physical agent; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Sphincter; Spinal; Spinal Canal Tumors; Spinal Canal and Spinal Cord Neoplasm; Spinal Column; Spinal Cord; Spinal Cord Diseases; Spinal Cord Disorders; Spinal Neoplasms; Spinal Tumors; Spine; Stereotactic External Beam Irradiation; Stereotactic Radiosurgery; Stereotaxic Radiosurgery; Suidae; Swine; Techniques; Technology; Testing; Time; Translating; Translatings; Treatment Side Effects; Tumor Cell Migration; Tumor of the Spinal Canal and Spinal Cord; Tumors; United States; Upper arm; Vertebrae; Vertebral; Vertebral column; Zeugmatography; backbone; base; cancer metastasis; clinical relevance; clinically relevant; experience; fighting; imaging; interventional strategy; irradiation; language translation; malignancy; motor deficit; myelopathy; neoplasia; neoplasm imaging; neoplasm/cancer; neoplastic growth; paralysis; paralytic; porcine; quantum; ray (radiation); repair; repaired; side effect; sound; spine bone structure; suid; therapy adverse effect; treatment adverse effect; trial regimen; trial treatment; tumor",Spinal Cord Tolerance to Radiosurgical Dose Delivery,,49517,RTB,Radiation Therapeutics and Biology Study Section,,6,349009,
7944183,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS050349-05,,NINDS:288387;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NEUROLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"SOTO, CLAUDIO ;",8370505;,5R01NS050349,08/02/2006,01/31/2011,"Acquired brain injury; Address; Affect; Affinity; Age; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Apoptosis; Apoptosis Pathway; Appearance; Area; Assay; Bacteria; Behavior; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological; Biological Assay; Blood; Blood Coagulation Factor IV; Blotting, Western; Body Tissues; Bovine Species; Brain; Brain Injuries; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CJD; CJDs (Creutzfeldt-Jakob Disease); Ca++ element; Calcium; Cattle; Cell Culture Techniques; Cell Death, Programmed; Cell-Death Protease; Cells; Cerebral Stroke; Cerebrospinal Fluid; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Chaperone; Chemistry, Biological; Circular Dichroism; Clinical; Co-Immunoprecipitations; Coagulation Factor IV; Combining Site; Creutzfeldt-Jacob Disease; Creutzfeldt-Jakob Disease; Creutzfeldt-Jakob Syndrome; Data; Death; Deer; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Detection; Detergents; Development; Diagnosis; Digestion; Disease; Disease Progression; Disorder; Disulfide Interchange Enzyme; Disulfide Isomerase; ERp59 PDI; Early Diagnosis; Encephalitis; Encephalon; Encephalons; Endoplasmic Reticulum; Ergastoplasm; Erp59; Esteroproteases; Event; Experimental Models; Experimental Models, Other; FTIR; FTIR spectroscopy; Factor IV; Fourier transform infrared spectroscopy; GSBP; Generations; Glycosylation Site-Binding Protein; Goals; Histology; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; ICE-like protease; Idiopathic Parkinson Disease; In Vitro; Individual; Infection; Inflammation, Brain; Intermediary Metabolism; Jakob-Creutzfeldt Disease; Knock-out; Knockout; Knockout Mice; Lead; Lewy Body Parkinson Disease; Liquid substance; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metabolic Processes; Metabolism; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Models, Experimental; Molecular; Molecular Chaperones; Molecular Interaction; Murine; Mus; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological; Neurological Disorders; Neuron Degeneration; Neurons; Null Mouse; Onset of illness; Organelles; PDI; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Patients; Pb element; Peptidases; Peptide Hydrolases; Peptides; Phase; Phenotype; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; PrP; PrP Proteins; PrP sequence; Predisposition; Primary Parkinsonism; Primary Senile Degenerative Dementia; Principal Investigator; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion Proteins; Prion-Induced Disorder; Prions; Process; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Property; Property, LOINC Axis 2; Proteases; Protein Disulfide Isomerase; Proteinases; Proteins; Proteolytic Enzymes; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Reactive Site; Reagent; Recombinants; Reporting; Resistance; Reticuloendothelial System, Blood; Rida; Role; S-S rearrangase; Sampling; Scrapie; Sequence-Specific Posttranscriptional Gene Silencing; Small Interfering RNA; Solubility; Specificity; Spectroscopy, Fourier Transform Infrared; Spongiform Encephalopathies, Transmissible; Spongiform Encephalopathy, Subacute; Staging; Stress; Stroke; Structure; Sulfhydryl-Disulfide Interchange Enzyme; Susceptibility; Symptoms; System; System, LOINC Axis 4; Technology; Testing; Thiol-Disulfide Transhydrogenase; Time; Tissues; Toxic effect; Toxicities; Transgenic Animals; Transgenic Organisms; Transmissible Dementias; Trypanothione-Glutathione Thioltransferase; Up-Regulation; Up-Regulation (Physiology); Upregulation; Variant; Variation; Vascular Accident, Brain; Western Blotting; Western Blottings; Western Immunoblotting; Work; aberrant protein folding; abnormal protein folding; apoptosis of neuronal cells; astrogliosis; base; bovid; bovine; brain attack; brain cell; brain damage; brain lesion (from injury); caspase; caspase 12; cerebral vascular accident; cow; cystein protease; cystein proteinase; cysteine endopeptidase; dementia of the Alzheimer type; disease diagnosis; disease onset; disease/disorder; disorder onset; dsbA Gene Product; dsbA Protein; dsbC Gene Product; dsbD Gene Product; early detection; endoplasmic reticulum stress; experiment; experimental research; experimental study; fluid; gene product; heavy metal Pb; heavy metal lead; in vivo; infected rodent; infected vector rodent; knock-down; liquid; model organism; mutant; nano; nervous system disorder; neural degeneration; neurodegeneration; neurodegenerative illness; neurological disease; neuron apoptosis; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal apoptosis; neuronal cell death; neuronal degeneration; neuronal loss; neuronal toxicity; neurotoxic; neurotoxicity; new diagnostics; next generation diagnostics; normal aging; novel; novel diagnostics; overexpression; pathologic protein folding; pathway; prevent; preventing; primary degenerative dementia; prion-based; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; protein blotting; protein expression; protein mis-folding; protein misfolding; protein misfolding cyclic amplification; research study; resistant; response; senile dementia of the Alzheimer type; siRNA; social role; spinal fluid; spongiform degeneration; spongiform encephalopathy; stroke; synthetic peptide; transgenic; tumors in the brain; xprA Gene Product",Neurodegeneration in prion diseases: Therapy and diagnosis,,50349,ZRG1,Special Emphasis Panel,,5,288387,
7752480,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS050634-04,,NINDS:367074;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROSCIENCES,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"BENSON, DEANNA L;",1882853;,5R01NS050634,01/15/2007,12/31/2010,"Actins; Address; Adhesions; Axon; Binding; Binding (Molecular Function); Brain; CALL Protein; Calcium Channel; Calcium Channel Antagonist Receptor; CamL1 Gene Product; Cell Surface Glycoprotein L1; Cellular Matrix; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clathrin; Complex; Cone; Cones (Eye); Cones (Retina); Cues; Cytoplasmic Protein; Cytoskeletal System; Cytoskeleton; Data; Development; Encephalon; Encephalons; Endocytosis; Environment; Exposure to; F11 Glycoprotein; Family; Fasciculation; Fasciculation, Muscular; Fasciculation, Neural; Foundations; Generalized Growth; Glia; Glial Cells; Goals; Growth; Growth Cones; Hamartin; Human; Human, General; Integral Membrane Protein; Intrinsic Membrane Protein; Ion Channels, Calcium; Kolliker's reticulum; L1 Cell Adhesion Molecule; L1CAM; Laboratories; Link; Lipid Rafts, Cell Membrane; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Microdomains; Membrane Protein Traffic; Membrane Traffic; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Muscle fasciculation; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nature; Nerve Cells; Nerve Growth Factor-Inducible Large External Glycoprotein; Nerve Unit; Nervous; Nervous System, Brain; Neural Adhesion Molecule L1; Neural Cell; Neural Cell Adhesion Molecule L1; Neurites; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Pathway interactions; Phase; Photoreceptors, Cone; Play; Process; Proteins; Receptor Protein; Receptors, Calcium Channel Blocker; Recruitment Activity; Regulation; Retinal Cone; Role; Signal Pathway; Small G-Proteins; Small GTPases; Source; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Sphingolipids; Surface; TSC1 protein; TSC1 protein, human; Time; Tissue Growth; Translating; Translatings; Transmembrane Protein; VDCC; Voltage-Dependent Calcium Channels; Work; axon growth; axon growth cone guidance; axon guidance; axonal growth; base; cone cell; desensitization; experiment; experimental research; experimental study; ezrin; gene product; human TSC1 protein; in vivo; intracellular skeleton; language translation; lipid raft; member; membrane structure; membrane-organizing extension spike protein; moesin; mutant; nerve cement; neural; neuronal; ontogeny; pathway; phosphoprotein p81; radixin; radixin protein; receptor; recruit; relating to nervous system; research study; response; rho; social role; trafficking",Mechanisms of Axon Outgrowth and Targeting,,50634,ZRG1,Special Emphasis Panel,,4,367074,
7749983,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS051048-05,,NINDS:333087;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DURHAM,UNITED STATES,PSYCHIATRY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"WOLDORFF, MARTY G.;",1979201;,5R01NS051048,01/01/2006,12/31/2010,"Address; Affect; Anterior; Anterior Quadrigeminal Body; Area; Attention; Attentional deficit; Auditory; Auditory Cortex; Auditory area; Binding; Binding (Molecular Function); Brain; Brain imaging; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Cognitive Discrimination; Corpora quadrigemina, superior colliculus; Data; Detection; Discrimination; Discrimination (Psychology); Distraction; Dorsal; Elements; Encephalon; Encephalons; Environment; Event; Event-Related Potentials; Exhibits; Face; Figs; Figs - dietary; Finding of distraction; Functional Magnetic Resonance Imaging; Goals; Grant; Group Processes; Grouping; Hand; Human; Human, General; Illusions; Individual; Intracellular Communication and Signaling; Investigators; Lateral; Lead; Life; Location; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Measures; Mental disorders; Mental health disorders; Modality; Molecular Interaction; Nervous; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Operation; Operative Procedures; Operative Surgical Procedures; Optic Tectum; Parietal; Pathway interactions; Pb element; Persons; Prefrontal Cortex; Process; Psychiatric Disease; Psychiatric Disorder; Receptor Protein; Recruitment Activity; Research Personnel; Research Resources; Researchers; Resources; Sensory; Sensory Process; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Sound; Sound - physical agent; Stimulus; Stream; Sum; Superior Colliculus; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Tectums, Optic; Time; Unspecified Mental Disorder; Vision; Visual; Visual Fields; Visual System; Visual attention; Visual system structure; Voice; Work; auditory stimulus; behavior measurement; behavioral measure; behavioral measurement; biological signal transduction; brain visualization; cingulate cortex; cognitive function; deviancy; deviant; distraction; event related potential; executive control; executive function; experiment; experimental research; experimental study; fMRI; facial; groupings; heavy metal Pb; heavy metal lead; hemodynamics; insight; mental illness; multisensory; nervous system disorder; neural; neural mechanism; neurological disease; neuromechanism; novel; pathway; psychological disorder; receptor; recruit; relating to nervous system; research study; response; sensory cortex; social group process; sound; superior colliculus Corpora quadrigemina; surgery; visual stimulus; visual tectum",Attentional Mechanisms in Multisensory Environments,,51048,COG,Cognitive Neuroscience Study Section,,5,333087,
7760188,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051238-05,,NINDS:366612;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,NEUROSCIENCES,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"PHILLIPS, GREG R;",3095363;,5R01NS051238,08/02/2006,01/31/2011,"Address; Adhesion Molecule; Adhesions; Adhesives; Affinity; Ammon Horn; Area; Assay; Axon; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Blood Coagulation Factor IV; Ca++ element; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cell Function; Cell Interaction; Cell Isolation; Cell Process; Cell Segregation; Cell Separation; Cell Separation Technology; Cell membrane; Cell physiology; Cell surface; Cell-to-Cell Interaction; Cells; Cellular Adhesion; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Code; Coding System; Cornu Ammonis; Cytoplasmic Membrane; Data; Dendrites; Deposit; Deposition; Embryo Development; Embryogenesis; Embryonic Development; Exhibits; External Domain; Extracellular Domain; Factor IV; Family; Gene Cluster; Generations; Genes; Genomics; Golgi; Golgi Apparatus; Golgi Complex; Hippocampus; Hippocampus (Brain); Intracellular Membranes; Life; Ligand Binding Protein; Light; Maps; Mass Spectrum; Mass Spectrum Analysis; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Modeling; Molecular; Molecular Interaction; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurites; Neurocyte; Neurons; Organelles; Pathway interactions; Photometry/Spectrum Analysis, Mass; Photoradiation; Plasma Membrane; Process; Property; Property, LOINC Axis 2; Proteins; Role; Sorting - Cell Movement; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Subcellular Process; Surface Proteins; Synapses; Synaptic; Synaptic Cleft; System; System, LOINC Axis 4; Testing; Time; Work; base; cell adhesion protein; cell sorting; extracellular; gene product; hippocampal; membrane structure; neural; neuronal; novel; pathway; plasmalemma; postsynaptic; relating to nervous system; social role; sorting; synapse formation; synaptogenesis; trafficking",Recognition coding at CNS synapses,,51238,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,5,366612,
7762744,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051241-05,,NINDS:228226;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLOTTESVILLE,UNITED STATES,PHARMACOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"ZHU, J. JULIUS ;",8369256;,5R01NS051241,02/03/2006,01/31/2011,"Abscission; Ammon Horn; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemical Pathway; Biologic Assays; Biological Assay; Biosynthetic Proteins; Cell Communication and Signaling; Cell Signaling; Cornu Ammonis; Dephosphorylation; Depotentiation; Depression; Disease; Disorder; EC 2.7.2-; Enzymes; Excision; Excitatory Synapse; Extirpation; Extracellular Signal-Regulated Kinases; Family; GTP; GTP Binding; GTP Phosphohydrolases; GTPases; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glutamate Receptor; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Guanosinetriphosphatases; Hippocampus; Hippocampus (Brain); Homosynaptic Depression; Image; Intracellular Communication and Signaling; Investigators; JN Kinase; JNK Mitogen-Activated Protein Kinases; JNK1 Kinase; JNK1 protein; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Knockout Mice; Lead; Learning; Link; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; MAP Kinase 8; MAP kinase; MAPK; MAPK8 Mitogen-Activated Protein Kinase; Measures; Mediating; Memory; Mental Depression; Mental Retardation; Metabolic Networks; Methods; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Modeling; Modification; Molecular; Molecular Interaction; Molecular Target; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Mutation; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Neural Development; Null Mouse; Pathway interactions; Pb element; Pharmacology; Phosphorylation; Physiologic; Physiological; Physiology; Preparation; Protein Dephosphorylation; Protein Phosphorylation; Psyche structure; Receptor Protein; Recombinant Proteins; Recombinants; Removal; Reporting; Research Personnel; Researchers; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Slice; Small G-Proteins; Small GTPases; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Surgical Removal; Synapses; Synaptic; Synaptic plasticity; Testing; Work; base; biological signal transduction; c jun; c-jun Amino-Terminal Kinase; c-jun Gene; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; disease/disorder; experiment; experimental research; experimental study; genome mutation; guanosinetriphosphatase; heavy metal Pb; heavy metal lead; hippocampal; imaging; improved; jun-NH2-Terminal Kinase; long term depression; mental; neurodevelopment; novel; pathway; postsynaptic; receptor; research study; resection; response; stress-activated protein kinase 1; synaptic depression; trafficking",Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways,,51241,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,5,228226,
7997194,R01,NS,5,,12/01/2009,11/30/2010,PAS-03-173,5R01NS051336-05,,NINDS:337544;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"JASMIN, LUC ;",1872874;,5R01NS051336,09/22/2006,11/30/2010,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Absence of pain sensation; Absence of sensibility to pain; Adverse effects; Affect; Afferent Neurons; Aminalon; Aminalone; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animals; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Area; Axon; Brain Stem; Brainstem; Butanoic Acids; Butanoic acid, 4-amino-; Butyric Acids; Cancers; Cardiac Diseases; Cardiac Disorders; Care, Health; Cell Nucleus; Cells; Central Nervous System; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Chronic; Clinical; Code; Coding System; Common Rat Strains; Cranial Nerve V; Cranial Pain; Disinhibition; Dose; Drugs; Dysfunction; Enzymes; Esthesia; Face; Face Pain; Facial Pain; Feels no pain; Fifth Cranial Nerve; Functional disorder; GABA; GABA Agonists; GABA Receptor Agonists; Gasser's Ganglion; Gasserian Ganglion; Gene Expression; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Glutamate Carboxy-Lyase; Glutamate Decarboxylase; Glutamic Acid Decarboxylase; Goals; Hand; Head Pain; Headache; Health Care Costs; Health Costs; Healthcare; Healthcare Costs; Heart Diseases; Heating; Human; Human, General; Hyperalgesia; Hyperalgesic Sensations; Individual; Injury; Intervention, Genetic; Isoforms; L-Glutamate-1-carboxy-lyase; Label; Life; Link; Loss of Sensation; Malignant Neoplasms; Malignant Tumor; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medication; Methods; Modeling; Molecular Biology, Gene Therapy; Motor; NK-1 Receptors; NK1R; NKIR; NRVS-SYS; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System; Nervous System, CNS; Nervous system structure; Nervus Trigeminus; Neural Cell; Neuraxis; Neurobiology; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurons, Afferent; Neurons, Sensory; Neurotransmitters; No sensitivity to pain; Nociception; Nucleus; Nucleus of the Fifth Nerve; Numbness; Operation; Operative Procedures; Operative Surgical Procedures; Oral; Pain; Pain Control; Pain Therapy; Pain management; Painful; Patients; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physicians; Physiopathology; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protocol; Protocols documentation; Radiation; Rat; Rattus; Receptor Gene; Receptor Protein; Receptors, Neurokinin-1; Resistance; Route; SP-P Receptors; Semilunar Ganglion; Sensation; Sensory; Sensory Cell Afferent Neuron; Site; Structure of trigeminal ganglion; Substance P Receptor; Surgical; Surgical Interventions; Surgical Procedure; Synaptic Vesicles; TAC1R; TACR1; Tachykinin Receptor 1; Testing; Therapy, DNA; Translations; Treatment Side Effects; Trigeminal Ganglias; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nuclei; Trigeminal nerve structure; Visit; allodynia; analgesia; behavioral disinhibition; chronic pain; chronic painful condition; cost; desensitization; drug/agent; facial; gamma-Aminobutyric Acid; gamma-Aminobutyric Acid Agonists; gene therapy; gene transfer vector; genetic therapy; heart disorder; hyperalgia; injured; innervation; malignancy; neoplasm/cancer; nerve injury; nerve supply; neural injury; neurobiological; neuronal; neuropathic pain; nociceptive; pain behavior; painful neuropathy; pathophysiology; preclinical study; prevent; preventing; programs; ray (radiation); receptor; resistant; side effect; surgery; therapy adverse effect; transfer of a gene; treatment adverse effect",Gene Therapy for Nerve Injury,,51336,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,5,337544,
7760657,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051383-06,,NINDS:307132;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW ORLEANS,UNITED STATES,OTHER BASIC SCIENCES,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"LU, YOUMING ;",8027113;,5R01NS051383,05/15/2006,01/31/2011,"ADAR2; ADARB1 protein; AMPA Receptors; AMPA receptor, GluR2 subunit; Address; Adenosine; Ammon Horn; Area; CRE Binding Protein; CREB; CREB Protein; Cause of Death; Common Rat Strains; Cornu Ammonis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Cytoplasmic Granules; DRADA2b protein; Data; Defect; Dentate Fascia; Dentate Gyrus; Developed Countries; Developed Nations; Disease; Disorder; Enzymes; Epileptogenesis; Fascia Dentata; Fore-Brain; Forebrain; Gene Expression; Gene Inactivation; Gene Products, RNA; Gene Silencing; Generations; Genes; GluR2 protein; GluR2 receptor; GluR2 subunit AMPA receptor; Glutamate Receptor; Glutamates; Gyrus Dentatus; Hippocampus; Hippocampus (Brain); Individual; Industrialized Countries; Industrialized Nations; Investigators; Ischemia; Ischemic Neuronal Injury; Ischemic Stroke; L-Glutamate; Lead; Mammals, Rats; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neuron Degeneration; Neuronal Injury; Neurons; Nuclear; Pattern; Pb element; Permeability; Physiologic; Physiological; Predisposition; Property; Property, LOINC Axis 2; Prosencephalon; Pyramidal neuron; RED1 (enzyme); RNA; RNA Editing; RNA Editings; RNA, Messenger, Editing; RNA, Non-Polyadenylated; RNA, Small Interfering; Rat; Rattus; Receptors, AMPA; Receptors, N-Methylaspartate; Reporting; Research Personnel; Researchers; Resistance; Ribonucleic Acid; Seizures; Site; Small Interfering RNA; Structure of dentate gyrus; Susceptibility; Synapses; Synaptic; Work; adenosine deaminase that acts on RNA; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; dADAR; dentate gyrus; desensitization; disease/disorder; double-stranded RNA-specific adenosine deaminase; dsRNA adenosine deaminase; dsRNA-specific adenosine deaminase; experiment; experimental research; experimental study; granule; heavy metal Pb; heavy metal lead; hippocampal; hippocampal pyramidal neuron; neural degeneration; neurodegeneration; neuron cell death; neuron injury; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuronal survival; research study; resistant; restoration; siRNA; transcription factor; vector",RNA editing of AMPA receptor subunit GluR2 in ischemia,,51383,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,6,307132,
7750494,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS051466-05,,NINDS:327717;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"OWYANG, CHUNG ;",1867698;,5R01NS051466,01/15/2006,12/31/2010,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Acetic Acids; Affective; Albumins; Allergy; Aminalon; Aminalone; Anaphylactic Reaction; Anaphylaxis; Anterior; Area; Brain; Butanoic acid, 4-amino-; CNS plasticity; CaM KII; CaM PK II; CaM kinase II; CaMKII; Causality; Cell Communication and Signaling; Cell Signaling; Colitis, Mucous; Colon or Rectum; Colon, Irritable; Colorectal; Common Rat Strains; Cutaneous; Disease; Disorder; Drugs; Encephalon; Encephalons; Etiology; Event; GABA; Glutamate Receptor; Glutamates; Human; Human, General; Hypersensitivity; Image; Intracellular Communication and Signaling; Irritable Bowel Syndrome; L-Glutamate; Lead; Learning; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Mammals, Rats; Man (Taxonomy); Man, Modern; Medial; Mediating; Mediation; Medication; Memory; Microdialysis; Modeling; Motor; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Negotiating; Negotiation; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Pathways; Neural Transmission; Neurocyte; Neuronal Plasticity; Neurons; Nociception; Pain; Pain Threshold; Pain Tolerance Level; Painful; Patients; Pb element; Pelvic; Pelvic Region; Pelvis; Perception; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Process; Property; Property, LOINC Axis 2; Public Health; Rat; Rattus; Role; Sensory; Shock, Anaphylactic; Signal Transduction; Signal Transduction Systems; Signaling; Splanchnic Nerves; Stimulus; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Testing; Thalamic Nuclei; Transmission; Visceral; Visceral Afferents; avoidance behavior; biological signal transduction; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cingulate cortex; colorectal distension; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; drug/agent; egg; gamma-Aminobutyric Acid; heavy metal Pb; heavy metal lead; imaging; irritation; long term depression; neural plasticity; neuronal; neuronal excitability; neuroplasticity; nociceptive; pain tolerance; public health medicine (field); response; social role; spastic colon; transmission process",ACC Sensitization in Visceral Hypersensitive Rats,,51466,ZRG1,Special Emphasis Panel,,5,327717,
7760071,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051509-05,,NINDS:353092;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROSCIENCES,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"BERGLES, DWIGHT E;",1890077;,5R01NS051509,02/01/2006,01/31/2011,"21+ years old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; AMPA Receptors; Adult; Affinity; Ag element; Agonist; Aminalon; Aminalone; Ammon Horn; Au element; Body Tissues; Brain; Brain region; Butanoic acid, 4-amino-; CSPG4; CSPG4 gene; Capacitance, Electrical; Cell Communication and Signaling; Cell Junctions; Cell Signaling; Cell membrane; Cells; Cerebellum; Cerebral Palsy; Communication; Cornu Ammonis; Corpus Callosum; Corpus Callosums; Cytoplasmic Membrane; Dependence; Development; Disease; Disorder; DsRed; Electric Capacitance; Electromagnetic, Laser; Electron Microscopy; Encephalon; Encephalons; Environment; Event; Fiber; Fracture; Freeze Fracturing; Freeze Fracturings; GABA; GABA Receptor; Glia; Glial Cells; Glutamate Receptor; Glutamates; Gold; Gramicidin; Gray; Gray unit of radiation dose; Hippocampus; Hippocampus (Brain); Human, Adult; Hypoxia; Hypoxic; In Situ; Infant; Injury; Intercellular Junctions; Intracellular Communication and Signaling; Investigators; Ischemia; Kinetic; Kinetics; Kolliker's reticulum; L-Glutamate; Label; Lasers; Lead; Life; Location; MCSP; MCSPG; MEL-CSPG; MSK16; Mammals, Mice; Maps; Measures; Membrane; Membrane Potentials; Methods; Mice; Mice, Transgenic; Mother Cells; Murine; Mus; Myelin; NG2; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neurotransmitters; Non-neuronal cell; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oxygen Deficiency; Pb element; Perinatal; Permeability; Photolyses; Physiologic; Physiological; Plasma Membrane; Play; Predisposition; Prevalence; Progenitor Cells; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Property; Property, LOINC Axis 2; Proteins; Radiation, Laser; Receptor Activation; Receptor Protein; Receptor Signaling; Receptors, AMPA; Receptors, gamma-Aminobutyric Acid; Regulation; Relative; Relative (related person); Research Personnel; Researchers; Resistance; Resolution; Rest; Resting Potentials; Role; Signal Transduction; Signal Transduction Systems; Signaling; Silver; Slice; Spatial Distribution; Stem cells; Structure; Susceptibility; Synapses; Synaptic; Tissues; Transgenic Mice; Transgenic Organisms; Transmembrane Potentials; V (voltage); adult human (21+); base; biological signal transduction; bone fracture; capacitance; cell behavior; density; disease/disorder; gamma-Aminobutyric Acid; gene product; heavy metal Pb; heavy metal lead; hippocampal; injured; membrane structure; nerve cement; neuronal; oligodendrocyte precursor; photolysis; plasmalemma; precursor cell; prevent; preventing; progenitor; programs; quantum; receptor; repair; repaired; resistant; response; social role; substantia alba; transgenic; voltage; white matter",Neuronal Regulation of NG2 Cells,,51509,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,5,353092,
7760080,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051764-05,,NINDS:394130;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"DAWSON, VALINA L.;",6236333;,5R01NS051764,08/15/2006,01/31/2011,"8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-; ALS; Address; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; American; Amyotrophic Lateral Sclerosis; Animal Model; Animal Models and Related Studies; Animals; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Area; Ataxia; Ataxy; Attention; Blood Serum; Body Tissues; Brain; Cause of Death; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Death, Programmed; Cell Signaling; Cell Survival; Cell Viability; Cells; Cellular injury; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Coordination Impairment; Death; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Dyssynergia; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Future; Gehrig's Disease; Genes; Goals; Healed; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Idiopathic Parkinson Disease; Incidence; Individual; Infarction; Injury; Intracellular Communication and Signaling; Investigators; Ischemia; Learning; Lewy Body Parkinson Disease; Lou Gehrig Disease; Lytotoxicity; Mediating; Medical; Mice, Transgenic; Modeling; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Names; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurons; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; QOL; Quality of life; Rare Diseases; Rare Disorder; Regulation; Research Personnel; Researchers; Resistance; Role; Seizure Disorder; Serum; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Staurosporine; Stroke; System; System, LOINC Axis 4; Tissues; Transgenic Mice; Vascular Accident, Brain; WHO; Withdrawal; World Health Organization; biological signal transduction; brain attack; cell damage; cell injury; cerebral vascular accident; cost; cytotoxicity; dementia of the Alzheimer type; disability; disease/disorder; epilepsia; epileptiform; epileptogenic; excitotoxicity; gene product; healing; in vivo; infarct; model organism; mouse model; necrocytosis; nervous system disorder; neural; neurological disease; neuronal; neuroprotection; novel; pathway; preconditioning; primary degenerative dementia; programs; protein expression; protein protein interaction; relating to nervous system; resistant; senile dementia of the Alzheimer type; social role; stroke",The Role of Iduna in Neuroprotection,,51764,ZRG1,Special Emphasis Panel,,5,394130,
7761699,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS051778-05,,NINDS:406146;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,BIOLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"HATTEN, MARY ELIZABETH;",1884917;,5R01NS051778,08/02/2006,01/31/2011,"21+ years old; Acute; Adult; Animals; Anterior; Antimorphic mutation; Apoplexy; Attention; Binding; Binding (Molecular Function); Biological Models; Birth Defects; Body Tissues; Brain; C elegans; C.elegans; Caenorhabditis elegans; Cek5 Ligand; Cek5 RPTK Ligand; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Signaling; Cell division; Cellular Migration; Centrosome; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Coloring Agents; Complex; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cytoplasmic Granules; Defect; Development; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dyes; EFNB1 Gene Product; Efbn2 Gene Product; Electromagnetic, Laser; Elk-L Protein; Encephalon; Encephalons; Eph Family Receptor Interacting Protein B1; Eph Receptor Ligands; Ephrin-B1; Ephrin-B2; Ephrins; Epilepsy; Epileptic Seizures; Epileptics; Eplg5 Gene Product; Eplg5 Protein; Evolution; Family; Fiber; Genes; Genetic; Goals; Human; Human, Adult; Human, General; Immigrations; In Vitro; In-Migration; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; JTB Protein; JTB protein, human; Jumping Translocation Breakpoint Protein; Kinesin; LERK-2 Protein; LERK-5 Gene Product; LERK-5 Protein; Label; Lasers; Learning Disabilities; Learning disability; Ligands; Light; Link; Locomotion; Mammalian Cell; Man (Taxonomy); Man, Modern; Membrane Channels; Mental Retardation; Methods; Mice, Transgenic; Model System; Models, Biologic; Molecular; Molecular Genetic Abnormality; Molecular Interaction; Monitor; Motility; Motility, Cellular; Motion; Movement; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nuclear; Nuclear Translocation; Nucleus; PAR Protein; PAR protein, human; PAR-6 protein; PTK Receptors; Pathway interactions; Photoradiation; Position; Positioning Attribute; Process; Prostate Androgen Regulated Protein; Proteins; Publishing; RTK; Radiation, Laser; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Regulation; Research; Role; Seizure Disorder; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Slice; Stroke; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Tissues; Transgenic Mice; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Vascular Accident, Brain; adult human (21+); axon growth cone guidance; axon guidance; biological signal transduction; body movement; brain attack; cell motility; cerebral vascular accident; chromophore; elk Ligand; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; gene function; gene product; granule; granule cell; human JTB protein; in vivo; insight; loss of function; migration; mutant; neuronal; novel; par-6 gene product; pathway; prostate androgen regulated protein, human; protein complex; receptor; research study; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; shRNA; short hairpin RNA; small hairpin RNA; social role; stroke",Role of mPAR6 Polarity CNS Neuronal Migration,,51778,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,5,406146,
7749966,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS052245-04,,NINDS:323544;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BRONX,UNITED STATES,NEUROSCIENCES,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"SCEMES, ELIANA ;",2095218;,5R01NS052245,01/15/2007,12/31/2011,"ADP Phosphohydrolase; ADPase; ATP Diphosphohydrolase; ATP-ADPase; ATP-Diphosphatase; Adenosine Diphosphatase; Applications Grants; Apyrase; Astrocytes; Astrocytus; Astroglia; Autocrine Systems; Bathing; Baths; Biochemical; Blood Coagulation Factor IV; Ca++ element; Calcium; Calcium Oscillations; Cell Communication and Signaling; Cell Growth in Number; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Migration; Cellular Proliferation; Coagulation Factor IV; Connexins; Connexon; Development; Diffusion; Enzymes; Event; Exocytosis; Factor IV; Gap Junction Proteins; Glia; Glial Cells; Gliosis; Goals; Grant Proposals; Grants, Applications; Image; In Vitro; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Kolliker's reticulum; Lytic; Measurement; Mediating; Mother Cells; Motility; Motility, Cellular; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Neural Cell; Neural Stem Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neuromodulator; Neurons; Neurotransmitters; Non-neuronal cell; Nucleotides; P2X; P2X-receptor; Paracrine Communication; Paracrine Signaling; Pathway interactions; Photons; Play; Progenitor Cells; Property; Property, LOINC Axis 2; Proteins; Purine Receptors; Purinoceptor; Receptor Protein; Receptors, Purinergic; Role; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Signal Transduction; Signal Transduction Systems; Signaling; Source; Staging; Stem cells; System; System, LOINC Axis 4; Time; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Waves, Calcium; autocrine; biological signal transduction; brain repair; cell motility; extracellular; fluorescence imaging; gene product; glial cell development; imaging; luminescence; migration; nerve cement; nerve stem cell; neural progenitor cells; neuronal; neuronal progenitor; neuronal progenitor cells; pathway; prevent; preventing; progenitor; receptor; repair; repaired; social role; traumatic brain damage",Mechanisms of ATP Release from Glial Progenitors,,52245,NDGB,Neural Degenerative Disorders and Glial Biology Study Section,,4,323544,
7760559,R01,NS,5,,03/01/2010,02/28/2011,PA-05-046,5R01NS052287-05,,NINDS:279014;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,NEUROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"SHIROMANI, PRIYATTAM J.;",6776876;,5R01NS052287,03/01/2006,02/28/2011,"1H-Imidazole-4-ethanamine; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Acetylcholine; Adenosine; Adenosine A1 Receptor; Affect; Agonist; Arousal; Automobile Driving; Behavioral; Brain; Brain Stem; Brainstem; Cells; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Conscious; Consciousness; Cortical Desynchronizations; Data; Delta Wave; Delta Wave sleep; Desynchronizations, Cortical; Drivings, Automobile; EEG; Editorial Comment; Editorial Comment (PT); Electroencephalography; Encephalon; Encephalons; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; FOS gene; Fire - disasters; Fires; Fore-Brain; Forebrain; G0S7; Gamma Globulin, 7S; Hcrt protein; Hcrt/ORX; Hcrt2 protein; Hcrts/ORXs; Histamine; Hour; Hypothalamic structure; Hypothalamus; IgG; Immunoglobulin G; In Vitro; Lateral; Lesion; Level of Evidence; Link; Mammals, Rats; Measures; Mediating; Metabolic; Method LOINC Axis 6; Methodology; Microdialysis; Modeling; Monitor; NREM (non rapid eye movement); Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neuropeptides; Paradoxical Sleep; Phenotype; Population; Pressure; Pressure- physical agent; Prosencephalon; Protooncogene FOS; Published Comment; REM Sleep; Rat; Rattus; Receptor Protein; Recovery; Regulation; Rhombencephalic Sleep; Role; Sleep; Sleep Deprivation; Sleep, Fast-Wave; Sleep, REM; Slow-Wave Sleep; System; System, LOINC Axis 4; Testing; Time; Transducers; Transgenic Organisms; Viewpoint; Viewpoint (PT); Wakefulness; Wakefulnesses; Work; awake; basal forebrain; basal forebrain cholinergic neurons; c fos; c-fos Gene; c-fos Proto-Oncogenes; cholinergic; cholinergic neuron; dreaming sleep; driving; experiment; experimental research; experimental study; extracellular; falls; hypocretin; hypocretin 2; hypocretin/orexin; hypocretins/orexins; hypothalamic; innervation; innovate; innovation; innovative; nerve supply; neuronal; non rapid eye movement; non-REM; non-rapid eye movement; nonrapid eye movement; orexin; orexin B; pressure; rapid eye movement sleep; receptor; research study; response; sleep control; sleep regulation; social role; transgenic; transport inhibitor; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",BASAL FOREBRAIN HYPOCRETIN REGULATION OF WAKING,,52287,BRS,Biological Rhythms and Sleep Study Section,,5,279014,
7751917,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS052397-04,,NINDS:368157;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"ROSEN, GLENN D;",1967516;,5R01NS052397,02/01/2007,01/31/2012,"Address; Affective Psychosis, Bipolar; Age; Anatomic; Anatomical Sciences; Anatomy; Area; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bio-Informatics; Bioinformatics; Bipolar Disorder; Brain; Breeding; Candidate Disease Gene; Candidate Gene; Cell Count; Cell Number; Celloidin; Cells; Cerebral cortex; Cognitive; Collection; Complement; Complement Proteins; Corpus Striatum; Corpus striatum structure; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Developmental reading disorder; Disease; Disorder; Dyslexia, Developmental; Encephalon; Encephalons; Expression Profiling; Expression Signature; Fore-Brain; Forebrain; Gene Expression; Gene Expression Profile; Gene Products, RNA; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Variation; Genotype; Gilles de la Tourette syndrome; Gilles de la Tourette's Disease; Glia; Glial Cells; Guinon's disease; Haplotypes; Inbred Strains Mice; Individual; Investigation; Investigators; Kanner's Syndrome; Knowledge; Kolliker's reticulum; Mammals, Mice; Maps; Measures; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Inbred Strains; Microarray Analysis; Microarray-Based Analysis; Molecular Fingerprinting; Molecular Profiling; Motor; Mouse Strains; Movement; Murine; Mus; Names; Neocortex; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Growth; Neurocyte; Neuroglia; Neuroglial Cells; Neuronal Growth; Neurons; Non-neuronal cell; Parents; Phenotype; Play; Population; Process; Programs (PT); Programs [Publication Type]; Prosencephalon; Psychosis, Manic-Depressive; QTL; Quantitative Trait Loci; RNA; RNA, Non-Polyadenylated; Racial Segregation; Reading Disability, Developmental; Recombinants; Relative; Relative (related person); Research Personnel; Research Resources; Researchers; Resources; Ribonucleic Acid; Role; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Specific qualifier value; Specified; Staging; Striate Body; Striatum; Structure; System; System, LOINC Axis 4; Techniques; Telencephalon; Tic Disorder, Combined Vocal and Multiple Motor; Tourette Syndrome; Tourette's; Tourette's Disease; Tourette's Disorder; Tourette's Syndrome; Transcript; Variant; Variation; Variation (Genetics); Work; allelic variant; anatomy; bipolar affective disorder; body movement; clinical data repository; clinical data warehouse; cognitive function; data repository; dementia praecox; design; designing; developmental disease/disorder; developmental disorder; disease/disorder; executive control; executive function; experiment; experimental research; experimental study; gene expression signature; genome-wide; homotypical cortex; isocortex; maladie des tics; manic depressive disorder; manic depressive illness; microarray technology; molecuar profile; molecular signature; neocortical; neopallium; nerve cement; neurogenesis; neuronal; programs; relational database; research study; schizophrenic; segregation; social role; striatal; tic de Guinon; trait; transcriptome",QTL mapping of cell number in the mouse CNS,,52397,ZRG1,Special Emphasis Panel,,4,368157,
7765626,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS052494-05,,NINDS:302115;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,NEUROLOGY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"RAUSCHECKER, JOSEF P;",1971177;,5R01NS052494,08/01/2006,01/31/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Anterior; Apoplexy; Area; Attention; Auditory; Auditory Cortex; Auditory Hallucination; Auditory agnosia; Auditory area; Auditory system; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Back; Behavioral; Biological Models; Categories; Cells; Cerebral Stroke; Cerebral cortex; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Chronic; Cognition; Cognitive; Communication; Complex; Comprehension; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Dorsal; Dorsum; Dyslexia; Electrodes, Miniaturized; Frequencies (time pattern); Frequency; Future; Hallucination, Auditory; Health; Human; Human, General; Injection of therapeutic agent; Injections; Investigators; Kanner's Syndrome; Knowledge; Label; Lateral; Link; Location; Macaca mulatta; Man (Taxonomy); Man, Modern; Mental disorders; Mental health disorders; Microelectrodes; Model System; Models, Biologic; Monkeys; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Noise; Parietal; Perception; Persons; Physiologic; Physiological; Physiology; Play; Position; Positioning Attribute; Prefrontal Cortex; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Reading; Research Personnel; Researchers; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Schizophrenia; Schizophrenic Disorders; Sight; Site; Sound; Sound - physical agent; Source; Space Perception; Spatial Discrimination; Stimulus; Stream; Stroke; Superior temporal gyrus; Symptoms; Systems Analyses; Systems Analysis; Tag; Temporal Lobe; Testing; Thalamic structure; Thalamus; Time; Tracer; Training; Unspecified Mental Disorder; Vascular Accident, Brain; Vision; Visual; Visual Cortex; Word Blindness; auditory discrimination; awake; base; brain attack; cerebral vascular accident; cognitive system; dementia of the Alzheimer type; dementia praecox; design; designing; disease/disorder; experiment; experimental research; experimental study; extrastriate visual cortex; feeding; frontal cortex; frontal lobe; mental illness; multisensory; neural; neural mechanism; neuromechanism; neuronal; non-human primate; nonhuman primate; perceptual spatial orientation; preference; primary degenerative dementia; programs; psychological disorder; relating to nervous system; research study; response; schizophrenic; senile dementia of the Alzheimer type; sensory system; social communication; social role; sound; spatial orientation; spatial orientation (perception); spatial perception; stroke; temporal cortex; temporal lobe/cortex; thalamic; visual cortical; vocalization",Visual and Auditory Processing Streams in the Cerebral Cortex,,52494,COG,Cognitive Neuroscience Study Section,,5,302115,
7750498,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS052495-04,,NINDS:600627;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PSYCHIATRY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"CAMPBELL, SCOTT ;",1868260;,5R01NS052495,02/15/2007,01/31/2012,"Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Address; Affect; Autoregulation; Behavior Control; Behavioral; Behavioral Manipulation; Biological; Biological Rhythm; Biological Rhythm and Oscillation; Blood; Body Temperature; Cell Culture Techniques; Chronic; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Collecting Cell; Cyclicity; Data; Diagnosis; Disease; Disorder; Disturbed Nyctohemeral Rhythm; Diurnal Rhythm; Dysfunction; Elements; Exhibits; Fatigue; Fats; Fatty acid glycerol esters; Fibroblasts; Functional disorder; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Markers; Genetic Polymorphism; Genetic defect; Homeostasis; Human; Human, General; Immunologic, Luciferase; Individual; Insomnia; Insomnia Disorder; Interdisciplinary Research; Interdisciplinary Study; Investigators; Laboratories; Lack of Energy; Length; Light; Luciferases; MT-bound tau; Man (Taxonomy); Man, Modern; Measurement; Measures; Melatonin; Methods; Methods and Techniques; Methods, Other; Molecular; Molecular Genetic; Molecular Genetics; Multidisciplinary Collaboration; Multidisciplinary Research; Mutation; Nature; Nyctohemeral Rhythm; Organism-Level Process; Organismal Process; Periodicity; Phase; Photoradiation; Physiologic; Physiologic Processes; Physiological; Physiological Homeostasis; Physiological Processes; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publishing; QOL; Quality of life; RT-PCR; RTPCR; Regulation; Relative; Relative (related person); Reporter; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reverse Transcriptase Polymerase Chain Reaction; Rhythmicity; Running; Sampling; Sampling Studies; Skin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep disturbances; Sleep-Wake Cycle Disorders; Sleep-Wake Schedule Disorders; Sleeplessness; Structure; Study Subject; Study, Interdisciplinary; System; System, LOINC Axis 4; Techniques; Testing; Time; Twenty-Four Hour Rhythm; Variant; Variation; Work; actigraphy; behavioral control; circadian; circadian clock; circadian pacemaker; circadian process; daily biorhythm; design; designing; disease/disorder; diurnal variation; genetic variant; genome mutation; insight; interdisciplinary approach; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; pathophysiology; polymorphism; programs; reverse transcriptase PCR; sleep control; sleep regulation; tau; tau Proteins; tau factor; virtual",AN INTERDISCIPLINARY STUDY OF DELAYED SLEEP PHASE DISORDER,,52495,ZRG1,Special Emphasis Panel,,4,600627,
7751817,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS053527-05,,NINDS:359549;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WINSTON-SALEM,UNITED STATES,ANATOMY/CELL BIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"OPPENHEIM, RONALD W;",1875608;,5R01NS053527,01/01/2006,12/31/2010,"21+ years old; ALS; Adhesion Molecule; Adult; Affect; Amyotrophic Lateral Sclerosis; Apoptotic; Aran-Duchenne disease; Assay; Aves; Avian; Axon; Bioassay; Biologic Assays; Biological Assay; Birds; Brain Diseases; Brain Disorders; Cell Adhesion Molecules; Cell Communication; Cell Communication and Signaling; Cell Death; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Cells; Cessation of life; Chronic; Cruveilhier disease; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Development; Embryo; Embryonic; Encephalon Diseases; Gehrig's Disease; Goals; Human, Adult; Intracellular Communication and Signaling; Intracellular Second Messenger; Intracellular Second Messengers; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Intramuscular; Lou Gehrig Disease; Mammals, Mice; Mediating; Mice; Molecular; Motor Cell; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Murine; Mus; Muscle; Muscle Tissue; Neonatal; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Onset of illness; Pathway interactions; Primary Lateral Sclerosis; Production; Proteins; Regulation; Role; Sclerosis, Lateral; Second Messenger Systems; Second Messengers; Second Messengers of Signal Transduction; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spinal; Spinal Muscular Atrophy; Synapses; Synaptic; Testing; adult human (21+); biological signal transduction; cell adhesion protein; design; designing; disease onset; disorder onset; experiment; experimental research; experimental study; extracellular; gene product; in vitro Model; in vivo; in vivo Model; mRNA Expression; motoneuron; necrocytosis; neurodegenerative illness; neuromuscular activity; neuronal; neuronal survival; neurotrophic factor; neurotrophin; neutrophin; new approaches; novel; novel approaches; novel strategies; novel strategy; pathway; prenatal; research study; retrograde transport; second messenger; social role; unborn; uptake",Neuromuscular Activity: Development and Survival of Avian and Mammalian Neurons,,53527,ZRG1,Special Emphasis Panel,,5,359549,
7749967,R01,NS,5,,01/01/2010,12/31/2010,PAS-04-072,5R01NS053560-05,,NINDS:378508;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"LO, ENG H.;",1889099;,5R01NS053560,01/01/2006,12/31/2010,"1D8 antigen; 4N1K; 4N1K peptide; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Acquired brain injury; Activator Protein-1; Acute; Adhesion Molecule; Agonist; Alteplase; Antibodies, Blocking; Antigenic Surface Determinant Protein OA3; Antigenic Surface Determinant Protein OA3 Gene; Apoplexy; Binding; Binding (Molecular Function); Blocking Antibodies; Blood; Blood - brain barrier anatomy; Blood Cells; Blood Plasma; Blood Vessels; Blood flow; Blood-Brain Barrier; Body Tissues; Bone Marrow Transplant; Bone Marrow Transplantation; Brain; Brain Hemorrhage, Cerebral; Brain Injuries; CD106; CD106 Antigens; CD36; CD36 gene; CD47; CD47 Antigen; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer); CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) Gene; CD47 Glycoprotein; CD47 Glycoprotein Gene; CD47 gene; CD54 (ICAM 1); CD54 Antigens; CSBP1; CSBP2; CSPB1; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cell-Death Protease; Cells; Cerebral Hemorrhage; Cerebral Ischemia; Cerebral Parenchymal Hemorrhage; Cerebral Stroke; Cerebral hemisphere hemorrhage; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Cessation of life; Clinical Trials; Clinical Trials, Unspecified; D-Glucose; Data; Death; Development; Dextrose; Disease; Disorder; EC 2.7.2-; EXIP; Encephalon; Encephalons; Endothelial Cells; Endothelium; Enhancer-Binding Protein AP1; Extracellular Signal-Regulated Kinases; Extravasation; FDA approved; GP3B; GP4; GPIV; Gelatinase B; Glucose; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Grafting, Bone Marrow; Hemato-Encephalic Barrier; Hemorrhage, Cerebrum; Hypoxia; Hypoxic; IAP Gene; IAP-50 antigen; ICAM-1; ICE-like protease; INCAM-110; INFLM; Immunoglobulin Enhancer-Binding Protein; Inducible Cell Adhesion Molecule 110; Infarction; Infiltration; Inflammation; Inflammation Mediators; Inflammatory; Injury; Integrin-Associated Protein; Integrin-Associated Protein Gene; Intercellular adhesion molecule 1; Intracellular Communication and Signaling; Intracerebral Hemorrhage; Investigators; Ischemic Stroke; JNK; JNK1; JNK1A2; JNK21B1/2; Knock-out; Knockout; Knockout Mice; Lead; Leakage; Leukocyte Surface Antigen CD47; Leukocyte Surface Antigen CD47 Gene; Ligands; MAP Kinase 8 Gene; MAP kinase; MAPK; MAPK14; MAPK14 gene; MAPK8; MAPK8 gene; MER6; MER6 Gene; MMP-9; MMP-9 Protein; MMP9; MMPs; MYD-1 Antigen; Macrophage Gelatinase; Mammals, Mice; Marrow Transplantation; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Mitogen-Activated Protein Kinases; Molecular Interaction; Murine; Mus; Mxi2; NF-kB; NF-kappa B; NF-kappaB; NFKB; NIH Program Announcements; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurologic outcome; Neurological outcome; Neuronal Dysfunction; Neurons; Neutrophil Infiltration; Neutrophil Recruitment; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; O element; O2 element; OA3; OA3 Gene; OA3 antigen; OVTL3 protein, human; Oxidative Stress; Oxygen; Oxygen Deficiency; PLAT; PRKM14; PRKM15; PRKM8; Pathway interactions; Patients; Pb element; Peripheral Blood Cell; Plasma; Program Announcement; Programs (PT); Programs [Publication Type]; Receptor Protein; Recombinant Tissue Plasminogen Activator; Research Personnel; Researchers; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Role; SAPK1; SAPK2A; SCARB3; SHPS-1 protein; SIRP-ALPHA-1; SIRPalpha1; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Spillage; Stroke; Strokes, Acute; Surface Antigen Identified by Monoclonal Antibody 1D8; Surface Antigen Identified by Monoclonal Antibody 1D8 Gene; T-Plasminogen Activator; THBS1; TSP; TSP-1; TSP1; TTPA; Testing; Thrombospondin 1; Tissue Activator D-44; Tissue Plasminogen Activator; Tissue-Type Plasminogen Activator; Tissues; Transcription Factor AP-1; Transcription Factor NF-kB; Type V Collagenase; Up-Regulation; Up-Regulation (Physiology); Upregulation; VCAM; VCAM-1; Vascular Accident, Brain; Vascular Cell Adhesion Molecule; Vascular Cell Adhesion Molecule-1; acute stroke; biological signal transduction; brain attack; brain damage; brain lesion (from injury); brain tissue; caspase; cell adhesion protein; cerebral vascular accident; clinical investigation; cystein protease; cystein proteinase; cysteine endopeptidase; deprivation; disease/disorder; effective therapy; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; in vivo; infarct; integrin-associated protein IAP, human; integrin-associated protein p50; kappa B Enhancer Binding Protein; meetings; mouse model; necrocytosis; neurobiological; neuron toxicity; neuronal; neuronal toxicity; neurotoxicity; neurovascular unit; novel; nuclear factor kappa beta; p38; p38 MAPK Gene; p38Alpha; pathway; programs; receptor; research study; response; signal-regulatory protein; social role; stress activated protein kinase; stroke; stroke therapy; t-PA; thrombolysis; thrombospondin-1 receptor CD47; vascular",CD47 as a neurovascular target for stroke therapy,,53560,CND,Clinical Neuroscience and Disease Study Section,,5,378508,
7760190,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS053575-05,,NINDS:344998;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"MACDERMOTT, AMY B;",2424557;,5R01NS053575,02/03/2006,01/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Action Potentials; Afferent Neurons; Aminalon; Aminalone; Axon Terminals; Body Temperature; Bone; Bone and Bones; Bones and Bone Tissue; Butanoic acid, 4-amino-; C Fiber; Caliber; Cations; Cell Body; Cells; Central Nervous System; Co-culture; Cocultivation; Coculture; Coculture Techniques; Detection; Diameter; Dorsal Root Ganglia; Electrophysiology; Electrophysiology (science); Fiber; GABA; Ganglia, Spinal; Glutamates; Heating; Image; Investigation; Investigators; Kinetic; Kinetics; L-Glutamate; Lead; Lecithinases; Measurable; Mediating; Medulla Spinalis; Membrane; Membrane Potentials; Muscle; Muscle Tissue; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, CNS; Neural Cell; Neural Transmission; Neuraxis; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology / Electrophysiology; Nociceptors; Pain; Painful; Pathway interactions; Pb element; Peripheral; Phospholipase; Physiologic; Physiological; Preparation; Presynaptic Terminals; Programs (PT); Programs [Publication Type]; Receptor Activation; Receptor Protein; Research Personnel; Researchers; Rest; Resting Potentials; Role; Sensory; Sensory Cell Afferent Neuron; Skin; Slice; Spinal; Spinal Cord; Spinal Ganglia; Stimulus; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; System; System, LOINC Axis 4; TRP channel; TRP protein; TRPV1; TRPV1 gene; Temperature; Testing; Training; Transducers; Transmembrane Potentials; Transmission; V (voltage); Viscera; afferent nerve; bone; cell body (neuron); dorsal horn; dorsal root ganglion; gamma-Aminobutyric Acid; heavy metal Pb; heavy metal lead; imaging; insight; membrane structure; neural cell body; neuronal; neuronal cell body; pathway; presynaptic; programs; receptor; receptor coupling; sensor; sensory nerve; social role; soma; transmission process; voltage",Transmitter release from peripheral sensory neurons,,53575,SCS,Somatosensory and Chemosensory Systems Study Section,,5,344998,
7770892,R01,NS,5,,03/01/2010,02/28/2011,,5R01NS053616-05,,NINDS:310619;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,TALLAHASSEE,UNITED STATES,OTHER BASIC SCIENCES,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"LEE, CHOOGON ;",8250845;,5R01NS053616,05/18/2006,02/28/2011,"Active Transport, Cell Nucleus; Affect; Affinity; Affinity Chromatography; Algae, Blue-Green; Antibodies; Antimorphic mutation; Behavioral; Binding; Binding (Molecular Function); Biochemical; Blue-Green Bacteria; Body Tissues; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Nucleus; Cells; Chemotherapy-Hormones/Steroids; Chromatography, Affinity; Chronic depressive disorder; Chronic depressive personality disorder; Circadian Rhythms; Clock protein; Complement; Complement Proteins; Complex; Cues; Cyanobacterium; Cyanophyceae; Cyanophyta; Cyclicity; DISSEC; Defect; Degradation Pathway; Degradative Pathway; Disease; Disorder; Dissection; Diurnal Rhythm; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Drosophila; Drosophila genus; Drosophila supernumerary limbs protein; EC 2.7; Electrophoresis; Endocrine Gland Secretion; Exhibits; Feedback; Flies; Fractionation, Electrophoretic; Fruit Fly, Drosophila; GeneHomolog; Genes; Genetic; Homolog; Homologous Gene; Homologue; Hormones; Human; Human Biology; Human, General; Investigators; Kinases; Knock-out; Knockout; Knockout Mice; Liver Extract; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Manias; Manic; Manic State; Mass Spectrum; Mass Spectrum Analysis; Mediating; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Modeling; Molecular; Molecular Interaction; Murine; Mus; Nuclear Transport; Nucleocytoplasmic Shuttling; Nucleus; Null Mouse; Nyctohemeral Rhythm; Organ System, Cardiovascular; Organism; Pathway interactions; Periodicity; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Physiology; Play; Post-Translational Regulation; Posttranslational Regulation; Process; Production; Programs (PT); Programs [Publication Type]; Protein Cleavage; Protein Phosphorylation; Proteins; Proteolysis; Proteomics; Regulation; Research Personnel; Researchers; Rhythmicity; Role; Seasonal Affective Disorder; Seasonal Mood Disorder; Sleep; Sleep Disorders; Sleep Wake Cycle; Slimb protein, Drosophila; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Testing; Therapeutic Hormone; Time; Tissue Extracts; Tissues; Transgenes; Transgenic Mice; Transphosphorylases; Twenty-Four Hour Rhythm; Vascular, Heart; affinity purification; alertness; casein kinase; chronic depression; circadian; circadian behavioral rhythms; circadian clock; circadian pacemaker; circadian process; circulatory system; combat; daily biorhythm; disease/disorder; diurnal variation; drug efficacy; experiment; experimental research; experimental study; fly; fruit fly; gene product; human disease; in vivo; intervention development; living system; member; mutant; novel; nucleocytoplasmic transport; pathway; positional cloning; programs; protein complex; research study; reverse genetics; seasonal depression; sleep problem; social role; supernumerary limbs protein, Drosophila; therapy development; tool; treatment development",Roles of casein kinase le/d and b-Trcp in the mammalian circadian clock,,53616,BRS,Biological Rhythms and Sleep Study Section,,5,310619,
7760569,R01,NS,5,,02/01/2010,01/31/2011,PAS-04-079,5R01NS053727-05,,NINDS:330924;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"BRAT, DANIEL J;",6724899;,5R01NS053727,04/01/2006,01/31/2011,"ANGPT2; Accounting; Ang-2; Ang2; Angiogenic Factor; Angiopoietin-2; Animal Model; Animal Models and Related Studies; Apoptosis; Apoptosis Pathway; Astrocytic Neoplasm; Astrocytic Tumor; Astrocytoma; Astrocytoma, Grade IV; Astroglioma; BZS; Blood Clot; Blood Clotting; Blood Coagulation Factor III; Blood Vessels; Blood coagulation; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CD142 Antigens; Causality; Cell Communication and Signaling; Cell Death, Programmed; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Migration; Cessation of life; Clotting; Coagulation; Coagulation Factor II Receptor; Coagulation Factor III; Coagulation Process; Coagulin; Data; Death; Development; Disease; Disease Progression; Disorder; ECM; Elements; Encephalon; Encephalons; Esteroproteases; Etiology; Event; Extracellular Matrix; F2R; Factor III; Factor, Angiogenesis; Genetic Alteration; Genetic Change; Genetic defect; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Glioma, Astrocytic; Glomerular Procoagulant Activity; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Heparin, Low-Molecular-Weight; Human; Human, General; Hypoxia; Hypoxic; In Vitro; Injury; Intracellular Communication and Signaling; Investigators; LMWH; Lead; Low-Molecular-Weight Heparin; MHAM; MMAC1; Malignant; Malignant - descriptor; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Mutant Strains; Motility; Motility, Cellular; Murine; Mus; Mutant Strains Mice; Mutation; Necrosis; Necrotic; Neoplasms; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Oxygen Deficiency; PAR-1 Receptor; PAR1 Receptor; PTEN; PTEN gene; PTEN1; Pathologic; Patients; Pattern; Pb element; Peptidases; Peptide Hydrolases; Peripheral; Phosphatase and Tensin Homolog; Primary Brain Neoplasms; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protease-Activated Receptor 1; Proteases; Protein Secretion; Proteinase-Activated Receptor 1; Proteinases; Proteins; Proteolytic Enzymes; Prothrombinase; Receptor Protein; Receptor, PAR-1; Research Personnel; Research Specimen; Researchers; Scheme; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Therapeutic; Thrombase; Thrombin; Thromboplastin; Thrombosis; Time; Tissue Factor; Tissue Factor Procoagulant; Tissue Thromboplastin; Translations; Tumor Cell; Tumor Expansion; Tumors; Tumors of Neuroglia; Urothromboplastin; VEGFs; Vascular Endothelial Growth Factors; Vegf; angiogenesis; base; biological signal transduction; cancer progression; cell motility; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; driving force; experiment; experimental research; experimental study; fibrinogenase; gene product; genome mutation; glioblastoma multiforme; heavy metal Pb; heavy metal lead; in vitro testing; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; migration; model organism; mouse model; mouse mutant; neoplasia; neoplasm progression; neoplastic cell; neoplastic growth; neoplastic progression; novel; offspring; prevent; preventing; programs; receptor; research study; spongioblastoma multiforme; tumor; tumor growth; tumor progression; tumors in the brain; vascular; vessel regression",Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.,,53727,TPM,Tumor Progression and Metastasis Study Section,,5,330924,
7760986,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS053796-04,,NINDS:318274;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,KANSAS CITY,UNITED STATES,PHYSIOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"SMITH, PETER G;",1866685;,5R01NS053796,02/01/2007,01/31/2011,"21+ years old; Actins; Address; Adult; Axon; Axon Terminals; BDNF; Biological Models; Body Tissues; Brain-Derived Neurotrophic Factor; Cell Communication and Signaling; Cell Death; Cell Membrane Permeability; Cell Signaling; Cells; Cellular Matrix; Ceramide (lipids); Ceramides; Chimp; Chimpanzee; Coloring Agents; Common Rat Strains; Cytoskeletal System; Cytoskeleton; Diestrus; Disease; Disorder; Dyes; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrous Cycle; Event; Exclusion; GP80-LNGFR; Genital System, Female, Uterus; Horns; Human, Adult; In Vitro; Intracellular Communication and Signaling; Investigation; Ligands; MGC34632; Mammals, Rats; Mammals, Rodents; Mediating; Membrane; Messenger RNA; Mitochondria; Model System; Models, Biologic; Molecular; Muscle, Involuntary; Muscle, Smooth; Myometrial; NGF Receptor; NGFR; NGFR Protein; NRVS-SYS; Natural regeneration; Nature; Nerve; Nerve Endings, Presynaptic; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity; Nerve Growth Factor Receptors; Nervous; Nervous System; Nervous system structure; Neural Pathways; Neurites; Neurologic Body System; Neurologic Organ System; Neuroreceptors; Neurotrophic Factor Receptor; Neurotropin Receptor p75; Pan; Pan Genus; Pan Species; Pathway interactions; Peripheral; Permeability; Phase; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Physiologic; Physiological; Presynaptic Terminals; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Proteins; RNA, Messenger; Rat; Rattus; Receptor Signaling; Receptor, Nerve Growth Factor; Receptors, NGF; Receptors, Nerve Growth Factor; Receptors, Neural; Receptors, Neurotrophin; Receptors, Sensory; Regeneration; Rodent; Rodentia; Rodentias; Role; Screening procedure; Sensory Receptors; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Smooth muscle (tissue); Sphingomyelin Cholinephosphohydrolase; Sphingomyelin Cleaving Enzyme; Sphingomyelin Phosphodiesterase; Sphingomyelinase; Sphingomyelinase C; Study models; Synaptic Boutons; Synaptic Terminals; Therapeutic Estrogen; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uterine Muscle; Uterus; Work; adult human (21+); axonal degeneration; biological signal transduction; brain-derived neurotrophic factor precursor; cofilin; density; depolymerization; disease/disorder; gene product; gp75 NGFR; in vivo; innervation; insight; intracellular skeleton; mRNA; membrane permeability; membrane structure; mitochondrial; mitochondrial membrane; myometrium; necrocytosis; nerve supply; neurotrimin; neurotrophic factor; neurotrophin; neutrophin; novel; p75 neurotrophin receptor; p75(NTR); p75NTR; pathway; pro-BDNF; regenerate; screening; screenings; social role; womb",Mechanisms of Sympathetic Axon Pruning,,53796,ZRG1,Special Emphasis Panel,,4,318274,
7760603,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS053946-04,,NINDS:325927;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DETROIT,UNITED STATES,NEUROLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"MAIESE, KENNETH ;",1875050;,5R01NS053946,02/01/2007,01/31/2012,"AKT; Akt protein; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Apoplexy; Apoptosis; Apoptosis Pathway; Apoptotic; Astrocytes; Astrocytus; Astroglia; Brain; Breast Neoplasms; Breast Tumors; CNS Diseases; CNS disorder; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Nucleus; Cell Protection; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cellular injury; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Cerebral Stroke; Cerebral cortex; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Common Rat Strains; Cornu Ammonis; Cytokine Activation; Cytoprotection; D-Glucose; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Dextrose; Disease; Disorder; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Family member; Fostering; Gene Inactivation; Gene Silencing; Genes; Genomics; Glucose; Hippocampus; Hippocampus (Brain); Hortega cell; Hour; In Vitro; Individual; Inflammatory; Injury; Intracellular Communication and Signaling; Investigation; Investigators; Ischemia-Reperfusion Injury; Ischemic Brain Injury; Ischemic Stroke; Knowledge; Link; Mammals, Rats; Mammary Cancer; Mammary Neoplasms; Membrane; Methods and Techniques; Methods, Other; Microglia; Middle Cerebral Artery Occlusion; Modeling; Molecular; Mononitrogen Monoxide; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nucleus; O element; O2 element; Occlusion, Middle Cerebral Artery; Oxidative Stress; Oxygen; PKB protein; Pathway interactions; Phosphatidylserines; Phosphorylation; Play; Primary Senile Degenerative Dementia; Protein Kinase B; Protein Phosphorylation; Proto-Oncogene Proteins c-akt; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; RNA, Small Interfering; Rapamycin Target Protein; Rat; Rattus; Reperfusion Damage; Reperfusion Injury; Research Personnel; Researchers; Role; Serine Phosphoglycerides; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Stroke; Techniques; Therapeutic; Transfection; United States; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular Accident, Brain; Wnt proteins; biological signal transduction; brain attack; c-akt protein; cell damage; cell injury; cerebral vascular accident; clinical care; cultured cell line; cytokine; dementia of the Alzheimer type; deprivation; disease/disorder; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; fork head protein; forkhead protein; forkhead transcription factors; gitter cell; hippocampal; human FRAP1 protein; in vivo Model; injured; innovate; innovation; innovative; ischemic brain damage; mTOR; mammary tumor; membrane structure; mesoglia; microglial cell; microgliocyte; neurodegenerative illness; neuronal; new therapeutic target; novel; overexpression; pathway; perivascular glial cell; phosphatidylserine receptor; prevent; preventing; primary degenerative dementia; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; receptor expression; related to A and C-protein; research study; senile dementia of the Alzheimer type; siRNA; social role; stroke; viral carcinogenesis",Impacting Oxidative Stress and Cell Injury through Novel Pathways of the Wnt Gene,,53946,CDIN,Cell Death in Neurodegeneration Study Section,,4,325927,
7751343,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS054022-05,,NINDS:337412;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,DURHAM,UNITED STATES,PHARMACOLOGY,04,044387793,US,NC,27705,DUKE UNIVERSITY,"YAO, TSO-PANG ;",6194085;,5R01NS054022,01/04/2006,12/31/2010,"APF-1; ATP-Dependent Proteolysis Factor 1; Abscission; Acetylation; Address; Adenosine Triphosphatase, Dynein; Binding; Binding (Molecular Function); Biogenesis; Cell Death; Cells; Cellular Inclusions; Chaperone; Clinical; Code; Coding System; Complex; Deacetylase; Deacetylation; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; E3 Ligase; E3 Ubiquitin Ligase; Employee Strikes; Excision; Extirpation; FLR; Failure (biologic function); HDAC6; HDAC6 gene; HMG-20; High Mobility Protein 20; Idiopathic Parkinson Disease; Inclusion Bodies; Investigators; JM21; KIAA0901; Knockout Mice; L-Lysine; Lewy Bodies; Lewy Body Parkinson Disease; Link; Lysine; MTOC; Mediating; Mice, Knock-out; Mice, Knockout; Micro-tubule; Microtubule Proteins; Microtubule-Organizing Center; Microtubules; Modification; Molecular; Molecular Chaperones; Molecular Interaction; Molecular Transport; Motor; NAC precursor; Nature; Nerve Cells; Nerve Degeneration; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Null Mouse; Origin of Life; PARK1 protein; PARK4 protein; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Pathogenesis; Pathway interactions; Physiologic; Physiological; Play; Polyubiquitin; Polyubiquitination; Primary Parkinsonism; Process; Programs (PT); Programs [Publication Type]; Protein Acetylation; Proteins; Removal; Research Personnel; Researchers; Role; SNCA; SNCA protein; Specificity; Stress-Induced Protein; Strikes; Strikes, Employee; Surgical Removal; Testing; Transport Process; Tubulin; Ubiquitilation; Ubiquitin; Ubiquitin Protein Ligase; Ubiquitin, poly-; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; aberrant protein folding; abnormal protein folding; alpha synuclein; alphaSP22; base; clinical relevance; clinically relevant; dynein ATP phosphohydrolase (tubulin translocating); failure; gene product; hD6; histone deacetylase 6; insoluble aggregate; mouse model; mutant; necrocytosis; neural degeneration; neurodegeneration; neurodegenerative illness; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; non A-beta component of AD amyloid; non A4 component of amyloid precursor; novel; novel therapeutic intervention; pathologic protein folding; pathway; prevent; preventing; programs; protein aggregate; protein mis-folding; protein misfolding; resection; response; social role; ubiquination; ubiquitin conjugation; ubiquitin-protein ligase",Histone deacetylase 6 and aggresome-associated neurodegeneration,,54022,ZRG1,Special Emphasis Panel,,5,337412,
7755370,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS054042-05,,NINDS:368846;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STONY BROOK,UNITED STATES,PHARMACOLOGY,01,804878247,US,NY,11794,STATE UNIVERSITY NEW YORK STONY BROOK,"COLOGNATO, HOLLY A;",6276831;,5R01NS054042,08/02/2006,01/31/2011,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antibodies, Blocking; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Binding Sites; Biological Models; Blocking Antibodies; Brain; C-terminal Src kinase; CSK; CSK Protein Kinase; CSK-src; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Co-culture; Cocultivation; Coculture; Coculture Techniques; Combining Site; Cranin; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Demyelinating Diseases; Demyelinating Disorders; Development; Disease; Disorder; Dystroglycan; Dystroglycans; EC 2.7; ECM; Encephalon; Encephalons; Engineering; Engineerings; Environment; Event; Extracellular Matrix; Extracellular Matrix, Integrins; Glycoprotein GP-2; Goals; Holly; Individual; Integrins; Intracellular Communication and Signaling; Investigators; Kanner's Syndrome; Kinases; Laminin; Laminin Receptor; Lead; Learning; MS (Multiple Sclerosis); Mammals, Mice; Mediating; Mice; Model System; Modeling; Models, Biologic; Molecular; Monitor; Multiple Sclerosis; Murine; Mus; Mutate; Myelin; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Pb element; Phenotype; Phosphotransferases; Play; Primary Senile Degenerative Dementia; Process; Programs (PT); Programs [Publication Type]; Protein-Tyrosine Kinase CYL; Reactive Site; Receptor Protein; Receptor Signaling; Regulation; Research; Research Design; Research Personnel; Researchers; Role; Schizophrenia; Schizophrenic Disorders; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Study Type; System; System, LOINC Axis 4; Testing; Transphosphorylases; Tyrosine-Protein Kinase CSK; biological signal transduction; brain cell; c-src Kinase; c-src Tyrosine Kinase; carboxy-terminal Src kinase; computerized data processing; data processing; dementia of the Alzheimer type; dementia praecox; design; designing; disease/disorder; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; in vivo; insular sclerosis; myelination; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal; neuronal degeneration; primary degenerative dementia; programs; protein-tyrosine kinase C-terminal Src kinase; protein-tyrosine kinase c-src; receptor; receptor binding; research study; schizophrenic; senile dementia of the Alzheimer type; shRNA; short hairpin RNA; signal processing; small hairpin RNA; social role; study design",Extracellular matrix regulation of myelination,,54042,NCF,Neurogenesis and Cell Fate Study Section,,5,368846,
7760587,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS054079-05,,NINDS:278951;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"LIN, WEILI ;",1901893;,5R01NS054079,08/07/2006,01/31/2011,"99m-Tc-HSA; 99mTc-HSA; Affect; Albumins; Animals; Apoplexy; Blood Serum; Blood erythrocyte; Blood normocyte; Body Temperature; Body Tissues; Brain region; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Clinical; Common Rat Strains; Coupled; Cyclotrons; Erythrocyte Volume, Packed; Erythrocytes; Erythrocytic; Evolution; Exhibits; Fever; Genetic; Hct; Hematocrit; Hematocrit procedure; Housing; Human; Human, General; Hyperthermia; Hypothermia; Image; Infarction; Injection of therapeutic agent; Injections; Injury; Ischemia; Ischemic Stroke; Knowledge; Label; Lead; Lesion; Life; Long-Evans Rats; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Marrow erythrocyte; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Medical Imaging, Single Photon Emission Computed Tomography; Medical center; Metabolic; Middle Cerebral Artery Occlusion; Modeling; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; O element; O2 element; Occlusion, Middle Cerebral Artery; Outcome; Oxygen; PET; PET Scan; PET imaging; PETSCAN; PETT; Packed Red-Cell Volume; Patients; Pb element; Physiologic; Physiological; Positron Emission Tomography Scan; Positron-Emission Tomography; Predictive Value; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; Pyrexia; Rad.-PET; Radionuclide Tomography, Single-Photon Emission-Computed; Rat; Rat Strains; Rats, Long-Evans; Rats, Wistar; Rattus; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reperfusion Therapy; Reporting; Reticuloendothelial System, Erythrocytes; SPECT; SPECT imaging; Serum; Simulate; Stroke; Strokes, Acute; System; System, LOINC Axis 4; Tag; Tc 99m; Tc 99m-Albumin Colloid; Tc-99m-HAM; Tc-99m-MAA; Tc-HAMM; Technetium 99m; Technetium Tc 99m Aggregated Albumin; Technetium-99m Albumin Colloid; Technology; Testing; Time; Tissue Viability; Tissues; Tomography, Emission-Computed, Single-Photon; Tracer; Vascular Accident, Brain; Viability, Tissue; Weight; Wistar Rats; Zeugmatography; acute stroke; base; blood corpuscles; brain attack; brain tissue; cerebral vascular accident; clinical relevance; clinically relevant; experiment; experimental research; experimental study; febrile; febris; heavy metal Pb; heavy metal lead; hypothermia, natural; imaging; improved; in vivo; indexing; infarct; injured; ischemic lesion; natural hypothermia; programs; reperfusion; research study; response; stroke; success; tool",MR Measured Oxygen Metabolic Index in Ischemic Stroke,,54079,CND,Clinical Neuroscience and Disease Study Section,,5,278951,
7760987,R01,NS,5,,02/01/2010,01/31/2011,PAS-03-092,5R01NS054124-05,,NINDS:334168;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"LOO, SANDRA K;",2059503;,5R01NS054124,02/15/2006,01/31/2011,"0-11 years old; AD/HD; ADHD; Affect; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavior; Behavior Disorders; Behavioral; Behavioral Symptoms; Biological; Blood; Brain; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Child; Child Youth; Children (0-21); Chromosome Mapping; Cognitive; Complex; Data; Data Collection; Data Linkages; Daydreams; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Dreams, Day; EEG; Electroencephalography; Encephalon; Encephalons; Family; Fathers; Freedom; Frequencies (time pattern); Frequency; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Heterogeneity; Genetic Variation; Genetics, Gene Mapping; Genotype; Goals; Grant; Heritability; Heterogeneity; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Impulsivity; Intervention; Intervention Strategies; Interview; Intracellular Communication and Signaling; Investigation; Investigators; Lead; Liberty; Link; Linkage Mapping; Linkages, Data; Measures; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Molecular Genetic; Molecular Genetics; Nervous System, Brain; Neurocognitive; Neuropsychologic Tests; Neuropsychological Tests; Parents; Parietal; Pathway interactions; Pattern; Pb element; Performance; Phenotype; Polymorphic Microsatellite Marker; Polymorphic marker; Predisposition gene; Programs (PT); Programs [Publication Type]; Racial Segregation; Reaction Time; Record Linkage Study; Relative; Relative (related person); Research; Research Personnel; Researchers; Response RT; Response Time; Reticuloendothelial System, Blood; Risk; Sampling; Short-Term Memory; Siblings; Signal Transduction; Signal Transduction Systems; Signaling; Sorting - Cell Movement; Structure; Susceptibility Gene; Testing; United States; Variant; Variation; Variation (Genetics); Work; affection; allelic variant; attention deficit hyperactive disorder; behavioral disorder; biological signal transduction; brain behavior; children; cost; disease subtype; disorder subtype; endophenotype; gene discovery; genetic mapping; heavy metal Pb; heavy metal lead; improved; inattention; inattentiveness; indexing; innovate; innovation; innovative; interventional strategy; offspring; pathway; predisposing gene; processing speed; programs; psychomotor reaction time; response; segregation; sorting; trait; working memory; youngster",Genetics of EEG Patterns in ADHD,,54124,CPDD,Child Psychopathology and Developmental Disabilities Study Section,,5,334168,
7755891,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS054193-04,,NINDS:309901;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,,30,075307785,US,CA,90048,CEDARS-SINAI MEDICAL CENTER,"LOWENSTEIN, PEDRO R;",6810604;,5R01NS054193,02/01/2007,01/31/2012,"Address; Adenoviral Vector; Adenoviridae; Adenovirus Vector; Adenoviruses; Adoptive Transfer; Ammon Horn; Animal Model; Animal Models and Related Studies; Astrocytes; Astrocytoma, Grade IV; Astrocytus; Astroglia; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; Brain; Brain Diseases; Brain Disorders; CD4 Antigen (P55); CD4 Antigens; CD4 Molecule; CD4 Positive T Lymphocytes; CD4 Protein; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; Cancer of Brain; Capsid; Cell Death; Cells; Cells, CD4; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials, Phase III; Clinical Trials, Unspecified; Clinical effectiveness; Code; Coding System; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Doctor of Philosophy; Down-Regulation; Down-Regulation (Physiology); Downregulation; Effectiveness; Effector Cell; Encephalon; Encephalon Diseases; Encephalons; Female; Gene Expression; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Generations; Genes; Genes, Viral; Genetic Intervention; Genome; Glioblastoma; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Hippocampus; Hippocampus (Brain); Hortega cell; Human; Human, General; Idiopathic Parkinson Disease; Immune; Immune response; Immune system; Immunity; Individual; Infection; Intervention, Genetic; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigators; Knockout Mice; LYT3; Lentivirinae; Lentivirus; Lewy Body Parkinson Disease; Life; Lytotoxicity; MS (Multiple Sclerosis); Malignant Tumor of the Brain; Malignant neoplasm of brain; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Medicine; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Microglia; Minor; Modeling; Molecular; Molecular Biology, Gene Therapy; Mouse Strains; Multiple Sclerosis; Murine; Mus; Myelin Proteins; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Null Mouse; OKT4 antigen; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oncolytic; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Ph.D.; PhD; Phase 3 Clinical Trials; Phase III Clinical Trials; Primary Parkinsonism; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Receptors, CD4; Receptors, Surface CD4; Regulation; Research Personnel; Researchers; Role; Safety; Science of Medicine; Sclerosis, Disseminated; Self-Antigens; Striate Body; Striatum; Subfamily lentivirinae; T-Cell Antigen T4/Leu3; T-Cell Surface Antigen T4/Leu-3; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; T4 molecule; Testing; Therapeutic; Therapy, DNA; Thymus-Dependent Lymphocytes; Transgenic Mice; Treatment Efficacy; Viral; Viral Genes; Viral Vector; Virus-Lenti; Work; adeno vector; adenovector; base; body system, allergic/immunologic; brain cell; cell transduction; cell type; cellular transduction; clinical investigation; clinical relevance; clinically relevant; coat (nonenveloped virus); cytolysin; cytotoxic; cytotoxicity; experiment; experimental research; experimental study; gene product; gene therapy; gene therapy clinical trial; genetic therapy; gitter cell; glioblastoma multiforme; gutless adenoviral vector; gutless adenovirus vector; helper T cell; helper T lymphocyte marker; hippocampal; host response; immunoresponse; improved; insular sclerosis; lymphocyte pore-forming protein; macrophage; male; mesoglia; microglial cell; microgliocyte; model organism; necrocytosis; neurodegenerative illness; neuronal; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; perforin; perivascular glial cell; phase 3 study; phase 3 trial; phase III trial; programs; protocol, phase III; research study; self recognition (immune); social role; spongioblastoma multiforme; striatal; study, phase III; therapeutic efficacy; therapeutic transgene; therapeutically effective; thymus derived lymphocyte; transduced cells; transgene expression; trial regimen; trial treatment; vector; vector genome; vector-induced",Gene Therapy and the Brain: Neuroimmune Interactions,,54193,ZRG1,Special Emphasis Panel,,4,309901,
7755369,R01,NS,5,,02/01/2010,01/31/2011,PAS-05-002,5R01NS054194-05,,NINDS:365291;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SONG, SHENG-KWEI ;",1884838;,5R01NS054194,08/15/2006,01/31/2011,"2,4-Imidazolidinedione, 5,5-diphenyl-; 5,5-Diphenylhydantoin; Active Immunization; Acute; Affect; Amino Acids; Amyloid A4 Protein Precursor; Amyloid Protein Precursor; Amyloid beta-Protein Precursor; Animal Model; Animal Models and Related Studies; Animals; Anisotropy; Attention; Autopsy; Axon; Biological Preservation; Body Tissues; Brain; Brain imaging; C.I. solvent blue 38; C57BL/6 Mouse; CNS Diseases; CNS disorder; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Cessation of life; Chronic; Clinical; Clinical Markers; Compensation; Data; Death; Defect; Demyelinations; Detection; Diagnosis; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Dilantin; Diphenylhydantoin; Disease; Disease Management; Disease remission; Disorder; Disorder Management; Dose; Dysfunction; EAE; Effectiveness; Electron Microscopy; Encephalomyelitis; Encephalomyelitis, Allergic; Encephalon; Encephalons; Evaluation; Event; Exhibits; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Fenitoin; Financial compensation; Fixation; Forecast of outcome; Formalin; Functional disorder; Future; H and E; H+ element; Hematoxylin and Eosin; Hematoxylin and Eosin Staining Method; Heterogeneity; Histology; Hour; Human; Human, General; Hydrogen Ions; INFLM; Image; Immersion; Immersion Investigative Technique; Impairment; Inflammation; Inflammatory; Inflammatory Response; Injury; Ink; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Lesion; Literature; Luxol Fast Blue MBS; Luxol fast blue; MOG glycoprotein; MR Imaging; MR Spectroscopy; MR Tomography; MRI; MRS; MRSI; MS (Multiple Sclerosis); Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Spectroscopy; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurement; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Methods; Mice; Modeling; Mouse Strains; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Murine; Mus; Myelin; Myelin Basic Proteins; Myelin Sheath; Myeloencephalitis; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; NMR Imaging; NMR Tomography; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurologic; Neurologic outcome; Neurological; Neurological outcome; Neurons; Nuclear Magnetic Resonance Imaging; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Pathologic; Pathology; Patients; Peptides; Phase; Phenytoin; Physiopathology; Preservation, Biologic; Preservation, Biological; Prognosis; Programs (PT); Programs [Publication Type]; Proteins; Proteolipids; Protocol; Protocols documentation; Protons; RMSN; Radial; Recovery; Recovery of Function; Relapsing-Remitting Multiple Sclerosis; Relative; Relative (related person); Remission; Reporting; Research Design; Research Personnel; Research Specimen; Researchers; SJL Mouse; Sclerosis, Disseminated; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Speed; Speed (motion); Spinal Cord; Staining method; Stainings; Stains; Study Type; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Intervention; Time; Tissues; Translations; Treatment Efficacy; Validation; Water Movements; Weight; Zeugmatography; aminoacid; amyloid precursor protein; autoimmune encephalomyelitis; axonal degeneration; base; biological signal transduction; brain visualization; diffusion anisotropy; diffusion tensor imaging; disability; disease/disorder; drug discovery; functional recovery; gene product; human tissue; imaging; improved; in vivo; indexing; inflammatory marker; injured; insular sclerosis; intervention therapy; methasol fast blue; model organism; mouse model; myelin oligodendrocyte glycoprotein; necropsy; neurofilament; neuronal; oligodendrocyte-myelin glycoprotein; outcome forecast; pathophysiology; postmortem; preservation; programs; prospective; sample fixation; study design; substantia alba; therapeutic efficacy; therapeutically effective; translational study; white matter; white matter injury",Noninvasive Quantification of Axon Damage in EAE and MS,,54194,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,365291,
7866458,R01,NS,5,,02/01/2010,01/31/2011,PAS-04-079,5R01NS054276-05,,NINDS:237704;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,OTHER BASIC SCIENCES,11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"RICH, JEREMY N;",2209328;,5R01NS054276,02/15/2006,01/31/2011,"Astrocytoma, Grade IV; Attenuated; BM 40 Protein; BM-40; Basement Membrane Tumor Protein; Biochemical; Biochemical Pathway; Brain; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Cysteine; Data; Dependence; EC 2.7; ECM; Encephalon; Encephalons; Event; Extracellular Matrix; FAK; FAK1; Focal Adhesion Kinase 1; Foundations; Gene Expression; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Glycoproteins; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Half-Cystine; Human; Human, General; ILK; In Vitro; Intracellular Communication and Signaling; Invaded; Kinases; L-Cysteine; Link; MMPs; Malignant Glial Neoplasm; Malignant Glial Tumor; Malignant Glioma; Malignant Neuroglial Neoplasm; Malignant Neuroglial Tumor; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Mediating; Metabolic Networks; Molecular; Molecular Weight; Neoplasms of Neuroglia; Nervous System, Brain; Neuroglial Neoplasm; Neuroglial Tumor; Osteonectin; Outcome; PTK Receptors; PTK2; PTK2 Protein Tyrosine Kinase 2; Pathway interactions; Patients; Phenotype; Phosphorylation; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Phosphorylation; Proteins; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RTK; Receptor Protein-Tyrosine Kinases; Regulation; Role; SPARC Glycoprotein; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Site; Stress; System; System, LOINC Axis 4; Testing; Transducers; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Treatment Failure; Tumor Cell; Tumor Cell Invasion; Tumor Invasion; Tumors of Neuroglia; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; base; biological signal transduction; conventional therapy; defined contribution; endogenous substrate pp120; focal adhesion kinase; focal adhesion protein tyrosine kinase; focal adhesion-associated protein tyrosine kinase pp125FAK; gene product; glioblastoma multiforme; glioma cell line; improved; in vivo; inhibitor; inhibitor/antagonist; integrin-linked kinase; kinase inhibitor; mutant; neoplastic cell; novel; overexpression; p125(FAK); p125FAK; p59(ILK); pathway; pp125(FAK); pp125FAK; programs; response; small molecule; social role; spongioblastoma multiforme; tumor; upstream kinase",Molecular Mechanisms of SPARC Mediated Glioma Invasion,,54276,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,237704,
7752544,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS054277-04,,NINDS:249480;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"CZEISLER, CHARLES A;",1875275;,5R01NS054277,02/15/2007,01/31/2012,"Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Actinotherapy; Acute; Affect; Arousal; Attention; Attenuated; Behavioral; Blood Plasma; Brain; Characteristics; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Cognitive; Data; Disturbed Nyctohemeral Rhythm; Diurnal Rhythm; EEG; Electroencephalography; Encephalon; Encephalons; Exposure to; Eye Movements; Fatigue; Future; History; Hour; Human; Human, General; Illumination; Incidence; Individual; Industry; Investigation; Investigators; Laboratories; Lack of Energy; Light; Light Therapy; Lighting; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Measures; Mediating; Medical; Melatonin; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuroendocrine; Neuroendocrine System; Neurons; Neurosecretory Systems; Nuclear Power Plants; Nurses; Nyctohemeral Rhythm; Operation; Operative Procedures; Operative Surgical Procedures; Output; Pathway interactions; Patients; Pattern; Performance; Personnel, Nursing; Phase; Photons; Photoradiation; Photoradiation Therapy; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Phototherapy; Plasma; Power Plants, Nuclear; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Reaction Time; Recording of previous events; Regulation; Research; Research Personnel; Researchers; Response RT; Response Time; Reticuloendothelial System, Serum, Plasma; Retina; Safety; Seasons; Serum, Plasma; Sleep Disorders; Sleep Disorders, Circadian Rhythm; Sleep-Wake Cycle Disorders; Sleep-Wake Schedule Disorders; Sn element; Son; Stannum; Stimulus; Structure of suprachiasmatic nucleus; Suprachiasmatic Nucleus; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Time; Tin; Training; Twenty-Four Hour Rhythm; Visual Receptor; alertness; circadian; circadian clock; circadian pacemaker; circadian process; daily biorhythm; density; desensitization; design; designing; diurnal variation; experience; field study; improved; light effects; light intensity; melanopsin; neurobehavioral; neuronal; novel; pathway; programs; psychomotor reaction time; response; sleep problem; suprachiasmatic nucleus; surgery; vigilance",Desensitization of Circadian Responses to Light,,54277,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,4,249480,
7761307,R01,NS,5,,02/01/2010,01/31/2011,PAS-05-024,5R01NS054742-04,,NINDS:300155;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PORTLAND,UNITED STATES,NEUROSCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"GOODMAN, RICHARD H.;",1887538;,5R01NS054742,02/01/2007,01/31/2011,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; Address; Attention; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome; BDNF; BDNF gene; Binding; Binding (Molecular Function); Binding Sites; Biology; Blotting, Northern; Brain; Brain-Derived Neurotrophic Factor; CHIP assay; CREB; CREB1; CREB1 gene; Cell Communication and Signaling; Cell Signaling; Cerebroatrophic Hyperammonemia; ChIP (chromatin immunoprecipitation); Chromatin; Coleonol; Combining Site; Complex; Development; Elements; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Fluorescence; Forskolin; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Transcription; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic Transcription; Genetic defect; Genetics, in situ Hybridization; Glia; Glial Cells; Goals; In Situ Hybridization; Intracellular Communication and Signaling; Investigators; Isoforms; Kolliker's reticulum; Laboratories; MGC34632; Mammals, Mice; MeCP-2 protein; MeCP2; MeCP2 protein; Measurement; Measures; Mediating; Method LOINC Axis 6; Methodology; Methods; Methyl CpG Binding Protein 2; Methyl CpG binding protein (MeCP2); Methyl CpG binding protein MeCP2; Methyl-CpG binding protein 2; Methyl-CpG-Binding Protein 2; Methyl-DNA binding protein MECP2; Mice; Micro RNA; MicroRNAs; Modeling; Modification; Molecular Interaction; Murine; Mus; Mutation; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Development; Neural Stem Cell; Neurocyte; Neurodevelopmental Disorder; Neuroglia; Neuroglial Cells; Neurological Development Disorder; Neurons; Non-neuronal cell; Northern Blotting; Northern Blottings; Nucleotides; Oligo; Oligonucleotides; Oligoribonucleotides; Pathway interactions; Pattern; Physiologic; Physiological; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Isoforms; RNA Expression; RNA blot analysis; RNA blotting; Reactive Site; Regulation; Research Personnel; Researchers; Rett Disorder; Rett Syndrome; Rett syndrome (RS, RTS); Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Specificity; Staging; System; System, LOINC Axis 4; Testing; Time; Transcript; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Regulation; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Translations; UTRs; Untranslated Regions; base; biological signal transduction; chromatin immunoprecipitation; genome mutation; granule cell; in situ Hybridization Staining Method; in vivo; methyl-CpG (cytosine-guanine dinucleotide) binding protein 2; miRNA; nerve cement; nerve stem cell; neural; neural progenitor cells; neurodevelopment; neuronal; neuronal progenitor; neuronal progenitor cells; new technology; novel; pathway; prevent; preventing; programs; protein expression; relating to nervous system; response; transcription factor",Regulation of MeCP2 by CREB-induced microRNAs,,54742,ZRG1,Special Emphasis Panel,,4,300155,
7760663,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS054784-04,,NINDS:323085;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,PEDIATRICS,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MARTIN, DONNA M;",1908820;,5R01NS054784,02/01/2007,01/31/2011,"21+ years old; Abdomen; Abdominal; Abdominal Wall; Abdominal wall structure; Adult; Affect; Alleles; Allelomorphs; Anterior Quadrigeminal Body; Antibodies; Assay; Axon; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Biology; Body Tissues; Brachydanio rerio; Brain; Brain Diseases; Brain Disorders; Brain region; Cardiac; Cardiac Abnormalities; Cardiac Defects, Congenital; Cardiac Malformation; Cardiac defect; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Locomotion; Cell Migration; Cell Movement; Cell Nucleus; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cellular Migration; Chest; Cognitive; Congenital Disorders; Congenital Heart Defects; Corpora quadrigemina, superior colliculus; DNA; Danio rerio; Defect; Deoxyribonucleic Acid; Development; Disorders, Congenital; Embryo; Embryonic; Encephalon; Encephalon Diseases; Encephalons; Exhibits; Eye; Eye Abnormalities; Eyeball; Future; Galactosidase; Gene Expression; Gene Proteins; Genes; Genes, LacZ; Genetics, in situ Hybridization; Heart; Heart Abnormalities; Heart Defects, Congenital; Heart Malformation; Homeo Domain; Human; Human, Adult; Human, General; Hypophysis; Hypophysis Cerebri; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Situ Hybridization; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigators; Isoforms; Knock-in; Knock-in Mouse; LacZ; LacZ Genes; Letters; Location; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mesencephalon; Mice; Mid-brain; Midbrain; Midbrain structure; Molecular Interaction; Motility; Motility, Cellular; Murine; Mus; Mutate; Names; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, Pituitary; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neurologic; Neurological; Neuronal Differentiation; Neuronal Growth; Neurons; Nodal; Nomenclature; Nucleus; Nucleus Subthalamicus; Optic Tectum; Organ; Phenotype; Pituitary; Pituitary Gland; Population; Production; Programs (PT); Programs [Publication Type]; Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Gene Products; Protein Isoforms; Proteins; Relative; Relative (related person); Reporter; Research Personnel; Researchers; Respiratory System, Lung; Rieger anomaly; Rieger malformation; Rieger syndrome; Rieger syndrome (RGS); Role; Signal Transduction; Signal Transduction Systems; Signaling; Structure of subthalamic nucleus; Subthalamic Nucleus; Superior Colliculus; Syndrome; Tectums, Optic; Testing; Thorace; Thoracic; Thorax; Time; Tissues; Tooth; Tooth structure; Umbilical Region; Umbilicus; Umbilicus (Anatomy); Ventral Lateral Nucleus; Ventral Lateral Thalamic Nucleus; Ventrolateral Nucleus of the Thalamus; Ventrolateral Thalamic Nucleus; Work; Zebra Danio; Zebra Fish; Zebrafish; abdominal wall; adult human (21+); biological signal transduction; brain disorder therapy; cell motility; congenital eye disease; congenital eye disorder; craniofacial; craniofacies; experiment; experimental research; experimental study; gene product; goniodysgenesis; heart defect; homeodomain; in situ Hybridization Staining Method; insight; iridodental dysplasia; iridogoniodysgenesis with somatic anomalies; loss of function; member; migration; mutant; nerve stem cell; neural progenitor cells; neurogenesis; neuron cell death; neuron development; neuron loss; neuronal; neuronal cell death; neuronal loss; neuronal progenitor; neuronal progenitor cells; novel; progenitor; programs; pulmonary; research study; social role; stem cell differentiation; superior colliculus Corpora quadrigemina; teeth; transcription factor; visual tectum",Pitx2 Function in Developing Mouse Brain Neurons,,54784,DBD,Developmental Brain Disorders Study Section,,4,323085,
7753187,R01,NS,5,,02/01/2010,01/31/2011,PAS-03-131,5R01NS054864-04,,NINDS:346557;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,15,603503991,US,NY,10031,CITY COLLEGE OF NEW YORK,"GHILARDI, M. FELICE MARINA;",1877590;,5R01NS054864,02/15/2007,01/31/2012,"(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid; (--)-3-(3,4-Dihydroxyphenyl)-L-alanine; 3-Hydroxy-L-tyrosine; Address; Animals; Area; Attention; Autoregulation; Behavioral; Bicycling; Brain region; CNS plasticity; Care Givers; Caregivers; Cerebrum; Characteristics; Collaborations; Computers; Data; Defect; Delta Wave; Delta Wave sleep; Development; Disease; Disease Progression; Disorder; Drugs; EEG; Electroencephalography; Electrophysiology; Electrophysiology (science); Frequencies (time pattern); Frequency; Goals; Heart; Homeostasis; Human; Human, General; Idiopathic Parkinson Disease; Image; Impairment; Intervention; Intervention Strategies; Investigation; Investigators; L-3,4-Dihydroxyphenylalanine; L-Dopa; Laboratories; Learning; Levodopa; Lewy Body Parkinson Disease; Life; Link; Location; Long-Term Potentiation; Man (Taxonomy); Man, Modern; Medication; Memory; Memory Deficit; Memory impairment; Motor; Motor Cortex; Motor Skills; Movement; NREM (non rapid eye movement); National Institute of Neurological Disorders and Stroke; Neuronal Plasticity; Neurophysiology / Electrophysiology; Paradoxical Sleep; Paralysis Agitans; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Physiological Homeostasis; Primary Parkinsonism; Process; Programs (PT); Programs [Publication Type]; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; QOL; Quality of life; REM Sleep; Research Personnel; Researchers; Rhombencephalic Sleep; Role; Rotation; Shoes; Sleep; Sleep Disorders; Sleep, Fast-Wave; Sleep, REM; Slow-Wave Sleep; Staging; Symptoms; Synaptic plasticity; Testing; Therapeutic; Therapeutic Intervention; Time; Training; Transcranial magnetic stimulation; Universities; Wakefulness; Wakefulnesses; Wisconsin; Work; Writing; base; beta-(3,4-Dihydroxyphenyl)-L-alanine; body movement; disease/disorder; dreaming sleep; drug/agent; effective therapy; experience; imaging; implicit memory; improved; indexing; intervention therapy; interventional strategy; kinematics; locomotor learning; motor impairment; motor learning; neural mechanism; neural plasticity; neuromechanism; neuroplasticity; non rapid eye movement; non-REM; non-rapid eye movement; nonrapid eye movement; novel; parietal cortex; programs; psycho-physiological; rapid eye movement sleep; response; skills; sleep control; sleep problem; sleep regulation; social role; visual motor; visuomotor",Consolidation of Motor Skills & Sleep Homeostasis in Parkinson's Disease,,54864,CND,Clinical Neuroscience and Disease Study Section,,4,346557,
7750492,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS054911-04,,NINDS:276440;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,BIOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"PRINZ, ASTRID ANTONIA;",8306201;,5R01NS054911,01/20/2007,12/31/2011,"Animals; Aspiration, Respiratory; Autoregulation; Back; Behavior; Biological Models; Biological Neural Networks; Blood Coagulation Factor IV; Breathing; Ca++ element; Calcium; Cells; Coagulation Factor IV; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dependence; Development; Disease; Disorder; Dorsum; Electrophysiology; Electrophysiology (science); Epilepsy; Epileptic Seizures; Epileptics; FLR; Factor IV; Failure (biologic function); Feedback; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Grant; Homeostasis; Hour; Human; Human, General; Hypoxia; Hypoxic; Inhalation; Inhaling; Inspiration, Respiratory; Investigators; Ion Channel; Ionic Channels; Lead; Life; Lobster; Man (Taxonomy); Man, Modern; Maps; Membrane; Membrane Channels; Model System; Modeling; Models, Biologic; Molecular; Monitor; Myxoid cyst; Nerve Cells; Nerve Unit; Neural Cell; Neural Ganglion; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Output; Oxygen Deficiency; Pathway interactions; Pattern; Pb element; Physiological Homeostasis; Play; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Regulation; Regulatory Pathway; Research Personnel; Researchers; Role; Seizure Disorder; Seizures; Signal Pathway; Simulate; Structure; Synapses; Synaptic; Testing; Time; Trauma; base; brain tissue; clinical data repository; clinical data warehouse; data repository; disease/disorder; environmental change; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; failure; feeding; heavy metal Pb; heavy metal lead; inspiration; membrane structure; network models; neural circuit; neural circuitry; neural network; neuronal; pathway; postsynaptic; presynaptic; programs; relational database; research study; response; sensor; simulation; social role",Activity-dependent homeostatic regulation in neural networks,,54911,SMI,Sensorimotor Integration Study Section,,4,276440,
7743570,R01,NS,5,,01/01/2010,12/31/2010,,5R01NS055015-04,,NINDS:331341;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,NEUROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"RYE, DAVID B;",1865100;,5R01NS055015,01/20/2007,12/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Adaptive Behaviors; Antibodies; Arousal; Autoregulation; Awareness; Awarenesses; Behavior; Behavioral; Behaviors, Adaptive; Brain; CARTPT gene; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cerebrospinal Fluid; Circadian Rhythms; Clinical; Cocaine and Amphetamine Regulated Transcript; Common Rat Strains; Depressed mood; Disease; Disorder; Diurnal Rhythm; Dopamine; Dose; Drugs; Dystrophia Myotonica; Eating; Encephalon; Encephalons; Endocrine; Excessive Daytime Sleepiness; Excessive daytime somnolence; Exhibits; Food Intake; Fostering; Gelineau Syndrome; Genetic; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Homeostasis; Human; Human, General; Hydroxytyramine; Hypersomnolence, Idiopathic; Hypothalamic structure; Hypothalamus; Idiopathic CNS Hypersomnolence; Idiopathic CNS Hypersomnolences; Idiopathic Central Nervous System Hypersomnolence; Idiopathic Hypersomnia; Idiopathic Hypersomnolence; Idiopathic Hypersomnolences; Impairment; Intracellular Communication and Signaling; Investigators; Lateral; Lead; Locomotion; Macaca mulatta; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Medication; Mesencephalon; Metabolic; Mice; Mid-brain; Midbrain; Midbrain structure; Motivation; Murine; Mus; Myotonia Atrophica; Myotonia Dystrophica; Myotonic Dystrophy; Narcolepsy; Narcoleptic Syndrome; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurons; Neuropeptides; Nucleus; Nyctohemeral Rhythm; Organism; Paradoxical Sleep; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Paroxysmal Sleep; Pathway interactions; Pattern; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiological Homeostasis; Programs (PT); Programs [Publication Type]; REM Sleep; Rat; Rattus; Receptor Protein; Regulation; Research Personnel; Researchers; Rewards; Rhesus; Rhesus Macaque; Rhesus Monkey; Rhombencephalic Sleep; Rodent; Rodentia; Rodentias; Role; Rye; Rye cereal; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Deprivation; Sleep Disorders; Sleep, Fast-Wave; Sleep, REM; Steinert Disease; System; System, LOINC Axis 4; Twenty-Four Hour Rhythm; Wakefulness; Wakefulnesses; adaptation behavior; adaptive behavior; alertness; base; biological signal transduction; brain pathway; cholinergic; circadian; circadian process; clinical significance; clinically significant; daily biorhythm; depressed; disease/disorder; diurnal variation; dreaming sleep; drug/agent; feeding; heavy metal Pb; heavy metal lead; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; insight; living system; neurobiological; neuronal; non-human primate; nonhuman primate; orexin; pathway; programs; psychostimulant; rapid eye movement sleep; receptor; sadness; sleep problem; social role; spinal fluid",CART regulation of wakefulness,,55015,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,4,331341,
7755839,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS055083-04,,NINDS:372666;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"BAKSHI, ROHIT ;",6412118;,5R01NS055083,04/01/2007,01/31/2011,"Accounting; Affect; Age; Atrophic; Atrophy; Biologic Marker; Biological Markers; Brain; Clinical; Clinical Trials, Therapy; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Demyelinating Diseases; Demyelinating Disorders; Deterioration; Diffuse; Disease; Disease Frequency Surveys; Disease Progression; Disorder; Disturbance in cognition; Dropsy; Edema; Encephalon; Encephalons; Goals; Gray; Gray unit of radiation dose; Hydrops; INFLM; Image; Impaired cognition; Impairment; Inflammation; Inflammatory; Investigators; Lesion; Link; Longitudinal Studies; MR Imaging; MR Tomography; MRI; MS (Multiple Sclerosis); Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Methods; Molecular Marker; Multiple Sclerosis; NMR Imaging; NMR Tomography; Nerve Degeneration; Nervous System, Brain; Neurologic; Neurological; Neuron Degeneration; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Nuclear Magnetic Resonance Imaging; Outcome Measure; Patients; Phenotype; Predictive Value; Programs (PT); Programs [Publication Type]; Relapse; Relative; Relative (related person); Research; Research Personnel; Researchers; SUBGP; Sclerosis, Disseminated; Secondary Progressive Multiple Sclerosis; Signature Molecule; Spinal Cord; Subgroup; Syndrome; Testing; Therapeutic Trials; Therapy Clinical Trials; Zeugmatography; biomarker; brain atrophy; brain tissue; brain volume; cerebral atrophy; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cortical atrophy; disability; disease/disorder; experience; gray matter; imaging; insular sclerosis; long-term study; neural degeneration; neurodegeneration; neuronal degeneration; programs; sex; substantia alba; substantia grisea; white matter",Gray vs. white matter brain atrophy in multiple sclerosis,,55083,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,4,372666,
7758740,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS055107-05,,NINDS:336040;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MIAMI,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,17,052780918,US,FL,33101,UNIVERSITY OF MIAMI SCHOOL OF MEDICINE,"MAUDSLEY, ANDREW A.;",7691074;,5R01NS055107,06/01/2006,12/31/2012,"1H- Nuclear Magnetic Resonance Spectroscopic Imaging; 2-Hydroxy-N,N,N-trimethylethanaminium; Accounting; Acquired brain injury; Active Follow-up; Affect; Age; Anisotropy; Blast Injuries; Body Tissues; Brain; Brain Concussion; Brain Injuries; Brain region; Cell Communication and Signaling; Cell Signaling; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Cerebral Concussion; Choline; Clinic; Clinical assessments; Closed head injuries; Cognitive; Commotio Cerebri; Cranial Pain; Craniocerebral Trauma; Development; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Dysfunction; Encephalon; Encephalons; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Evaluation; Exhibits; Forecast of outcome; Functional disorder; Gray; Gray unit of radiation dose; H+ element; Head; Head Injuries; Head Injuries, Nonpenetrating; Head Pain; Head Trauma; Head Trauma, Closed; Headache; Hydrogen Ions; Hydrogen Oxide; Image; Image Analyses; Image Analysis; Individual; Injuries, Craniocerebral; Injury; Intermediary Metabolism; Intracellular Communication and Signaling; Lobar; Location; METBL; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Maps; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Membrane; Metabolic; Metabolic Marker; Metabolic Processes; Metabolism; Methods; Minor; N-acetyl aspartate; N-acetyl-L-aspartate; N-acetylaspartate; NMR Imaging; NMR Tomography; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neuronal Dysfunction; Neurons; Normal Range; Normal Values; Nuclear Magnetic Resonance Imaging; Outcome; Outcome Measure; Patients; Pattern; Performance; Physiopathology; Post-Concussion Symptoms; Post-Concussion Syndrome; Post-Concussive Symptoms; Post-Concussive Syndrome; Post-Traumatic Headaches; Prognosis; Proton Magnetic Resonance Spectroscopic Imaging; Protons; Public Health; ROC Analysis; Reaction; Recovery of Function; Relaxation; Reporting; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Sports; Symptoms; Testing; Time; Tissues; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Water; Zeugmatography; base; biological signal transduction; brain damage; brain lesion (from injury); cognitive function; concussion; diffusion tensor imaging; expectation; follow-up; functional outcomes; functional recovery; image evaluation; imaging; improved; magnetic resonance spectroscopic imaging; membrane structure; neuroimaging; neuronal; neuropsychological; outcome forecast; pathophysiology; public health medicine (field); public health relevance; restoration; spectroscopic imaging; substantia alba; traumatic brain damage; white matter",Volumetric MRSI Evaluation of Traumatic Brain Injury," This project will evaluate improved quantitative MR neuroimaging methods for assessment of the metabolic and micro-structural changes associated with mild brain injury. These objective measures will guide treatment and patient management decisions following mild head trauma, as well as providing expectations for long-term consequences of the injury. Patient groups affected by this common injury include sports-related injuries and blast-related concussion.",55107,BMIT,Biomedical Imaging Technology Study Section,,5,336040,
7761705,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS055158-05,,NINDS:409870;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"GOTTESFELD, JOEL M.;",6325124;,5R01NS055158,04/01/2006,01/31/2011,"Adopted; Affect; Affinity; Alanine; Alanine, L-Isomer; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Binding; Binding (Molecular Function); Bioavailability; Biologic Availability; Biological Availability; Blood - brain barrier anatomy; Blood Sample; Blood Serum; Blood donor; Blood specimen; Blood-Brain Barrier; Blotting, Western; Body Tissues; Cell Line; Cell Lines, Strains; Cell Nucleus; CellLine; Cells; Chemistry; Cultured Cells; DNA; DNA Binding; DNA Binding Interaction; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; DNA Sequence; DNA Structure; DNase-I Footprinting; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deoxyribonucleic Acid; Development; Drug Kinetics; Drug or chemical Tissue Distribution; Drugs; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Freidreich's Ataxia; Friedreich Ataxia; Friedreich Disease; Friedreich Spinocerebellar Ataxia; Friedreich's Familial Ataxia; Friedreich's Hereditary Ataxia; Friedreich's tabes; Funding; Gene Expression; Gene Products, RNA; Gene Targeting; Gene Transcription; Generations; Genes; Genetic Condition; Genetic Diseases; Genetic Transcription; Grant; Half-Life; Half-Lifes; Hemato-Encephalic Barrier; Hereditary; Hereditary Disease; Hereditary Spinal Ataxia, Friedreich's; Housekeeping Gene; Human; Human, General; Inherited; Intervening Sequences; Introns; Kinetic; Kinetics; Knock-in; Knock-in Mouse; L-Alanine; Ligands; Link; Lymphoid Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Medication; Messenger RNA; Mice; Microarray Analysis; Microarray-Based Analysis; Microscopy; Mitochondrial Proteins; Modeling; Molecular; Molecular Disease; Molecular Interaction; Monitor; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurological Disorders; Neurons; Nuclear; Nucleus; Nylons; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacokinetics; Physiologic Availability; Polyamides; Property; Property, LOINC Axis 2; Proteins; Pyrroles; RNA; RNA Expression; RNA, Messenger; RNA, Non-Polyadenylated; Repression; Research; Ribonucleic Acid; Science of Chemistry; Sclerosis, Hereditary Spinal; Series; Serum; Short Tandem Repeat; Simple Sequence Repeat; Site; Specificity; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic; Time; Tissue Distribution; Tissues; Toxic effect; Toxicities; Transcription; Transcription Regulatory Protein; Transcription, Genetic; Transcriptional Regulatory Protein; Triplet Multiple Birth; Triplets; United States National Institutes of Health; Western Blotting; Western Blottings; Western Immunoblotting; base; bioavailability of drug; cell type; cultured cell line; dosage; drug/agent; established cell line; experiment; experimental research; experimental study; family ataxia; fluorescent dye/probe; frataxin; gene product; genetic disorder; genome-wide; hereditary disorder; in vivo; mRNA; mRNA Expression; microarray technology; model organism; nervous system disorder; neurodegenerative illness; neurological disease; neuronal; protein blotting; research study; small molecule; synthetic DNA; synthetic construct; uptake",Small Molecular Therapeutics for Friedreich's Ataxia,,55158,ZRG1,Special Emphasis Panel,,5,409870,
7753650,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS055179-03,,NINDS:302104;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PHARMACOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HALL, RANDY A.;",1889844;,5R01NS055179,02/01/2008,01/31/2013,"Address; Animal Welfare; Antibodies; Astrocytes; Astrocytus; Astroglia; Bibliography; Binding; Binding (Molecular Function); Brain; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Country; Data; Ecological impact; Editorial Comment; Editorial Comment (PT); Electron Microscopy; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Glutamate Receptor; Glutamate Translocase; Glutamate Transport Glycoprotein; Glutamate Transporter; Glutamates; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Knockout Mice; L-Glutamate; Language; Mammals, Mice; Metabotropic Glutamate Receptors; Mice; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Murine; Mus; NHE-RF protein; NHERF; Na+-H+ exchanger-regulatory factor; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Neurotransmitters; Null Mouse; Play; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Published Comment; Receptors, Metabotropic Glutamate; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Sorting - Cell Movement; Synapses; Synaptic; Synaptic Cleft; TXT; Text; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); abstracting; biological signal transduction; experiment; experimental research; experimental study; expiration; gene product; human subject; improved; mGluR3; metabotropic glutamate receptor 3; neuronal; programs; research study; scaffold; scaffolding; sodium-hydrogen exchanger regulatory factor; sorting; vertebrata",PDZ scaffold regulation of astrocytic glutamate receptors and transporters,,55179,CMBG,Cellular and Molecular Biology of Glia Study Section,,3,302104,
7754652,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS055256-05,,NINDS:233593;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,MILAN,ITALY,,,440850089,IT,,20132,FONDAZONE CENT/SAN RAFFAELE/DEL MONTE,"WRABETZ, LAWRENCE ;",8316760;,5R01NS055256,04/01/2006,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; Ablation; Accounting; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Antimorphic mutation; Apoptosis; Apoptosis Pathway; Apoptotic; Arm; C/EBP homologous protein; CHOP protein; CHOP-10 protein; Categories; Cell Death; Cell Death, Programmed; Cells; Charcot Marie Disorder; Charcot Marie Muscular Atrophy; Charcot Marie Tooth Disorder; Charcot Marie Tooth muscular atrophy; Charcot-Marie Disease; Charcot-Marie-Tooth; Charcot-Marie-Tooth Disease; Charcot-Marie-Tooth neuropathy; DDIT3 protein; DNA damage-inducible transcript 3 protein; Data; Defect; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Demyelinations; Diabetes Mellitus; Disease; Disorder; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; Dose; Economics; Endoplasmic Reticulum; Ergastoplasm; Fiber; GADD153 protein; Gene Expression; Gene Targeting; Gene Transcription; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Glia; Glial Cells; Half-Life; Half-Lifes; Human; Human, General; Inherited Neuropathy; Investigators; Killings; Knockout Mice; Kolliker's reticulum; Lipids; Location; MPZL1; MPZL1 protein, human; Macropain; Macroxyproteinase; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Modeling; Multicatalytic Proteinase; Murine; Mus; Mutant Strains Mice; Mutation; Myelin; Myelin P0 Protein; Myelin Protein Zero; Myelin Protein Zero-Like 1; Myelin Proteins; Myelin Sheath; Nerve; Nervous; Neurilemma Cell; Neurilemmal Cell; Neuroglia; Neuroglial Cells; Neuropathy; Non-neuronal cell; Nonsense Mutation; Null Mouse; Onions; Onset of illness; P0 Glycoprotein; P0 Protein; PZR; PZR protein, human; Pathogenesis; Peripheral; Peroneal Muscular Atrophy; Phenotype; Physiologic; Physiological; Primary Senile Degenerative Dementia; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Protein Zero, Peripheral Nerve Myelin; Protein Zero-Related; Proteins; Proteosome; RNA Expression; RNA Splicing; Research Personnel; Researchers; Role; Schwann Cells; Splicing; Structural Protein; Syndrome; Targetings, Gene; Testing; Therapeutic; Time; Toxic effect; Toxicities; Transcription; Transcription, Genetic; Transgenic Mice; Upper arm; Weight; aberrant protein folding; abnormal protein folding; biological adaptation to stress; caspase 12; cell killing; dementia of the Alzheimer type; design; designing; diabetes; disability; disease onset; disease/disorder; disorder onset; dosage; functional restoration; gain of function; gene product; genome mutation; hereditary neuropathy; human MPZL1 protein; loss of function; member; mouse model; mouse mutant; multicatalytic endopeptidase complex; mutant; myelin protein zero-like 1, human; myelination; myelinopathy; necrocytosis; nerve cement; neuromuscular; neuropathic; novel; overexpression; pathologic protein folding; primary degenerative dementia; programs; protein degradation; protein expression; protein mis-folding; protein misfolding; reaction; crisis; response; restore function; restore functionality; restore lost function; senile dementia of the Alzheimer type; social role; stress response; stress; reaction; transcription factor; transcription factor CHOP",Pathogenesis of Myelin Protein Zero Neuropathies in Transgenic Mice,,55256,NDBG,Neurodegeneration and Biology of Glia Study Section,,5,233593,
7753155,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS055293-03,,NINDS:324822;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,BIOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"REN, DEJIAN ;",7595974;,5R01NS055293,01/01/2008,12/31/2012,"Address; Ammon Horn; Animal Welfare; Animals; Aspiration, Respiratory; Bibliography; Birth; Blood Coagulation Factor IV; Blotting, Northern; Breathing; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; CatSper; Cell Communication and Signaling; Cell Signaling; Cells; Cesium; Cloning; Coagulation Factor IV; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Cornu Ammonis; Country; Cs element; Defect; Development; Direct Costs; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equipment; Ethics Committees, Research; Euler-Gaddum Substance P; Evaluation; FLR; Factor IV; Failure (biologic function); Family; Funding; Gated Ion Channel; Gene Expression; Genes; Genetics, in situ Hybridization; Grant; Hippocampus; Hippocampus (Brain); Hodgkin Disease; Hodgkin Disorder; Hodgkin lymphoma; Hodgkin's; Hodgkin's Lymphoma; Hodgkin's disease; Hodgkins lymphoma; Hour; IACUC; IRBs; Impact, Environmental; In Situ; In Situ Hybridization; Inhalation; Inhaling; Inspiration, Respiratory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigators; Ion Channel; Ion Channels, Calcium; Ion Channels, Potassium; Ion Channels, Sodium; Ionic Channels; Ions; K channel; Knock-out; Knockout; Left; Lymphogranuloma, Malignant; Manuscripts; Medulla Spinalis; Membrane Channels; Membrane Potentials; Membrane Proteins; Membrane-Associated Proteins; Messenger RNA; Mice, Mutant Strains; Molecular; Mutant Strains Mice; NK-1 Receptors; NK1R; NKIR; NRVS-SYS; Na element; Nature; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurotransmitters; Northern Blotting; Northern Blottings; Palsy; Paper; Paralysed; Parturition; Phenotype; Physiologic; Physiological; Physiology; Plegia; Postdoc; Postdoctoral Fellow; Potassium Channel; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Publications; Published Comment; RNA blot analysis; RNA blotting; RNA, Messenger; Reader; Receptor Protein; Receptors, Calcium Channel Blocker; Receptors, Neurokinin-1; Recruitment Activity; Regulation; Reproduction; Research; Research Associate; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Rest; Resting Potentials; Role; Running; SP(1-11); SP-P Receptors; Science; Scientific Publication; Scientist; Seizure Disorder; Seizures; Signal Transduction; Signal Transduction Systems; Signaling; Sodium; Sodium Channel; Spinal Cord; Structure; Substance P; Substance P Receptor; Surface Proteins; TAC1R; TACR1; TACR1 gene; Tachykinin Receptor 1; Time; Training; Transmembrane Potentials; V (voltage); VDCC; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Voltage-Dependent Calcium Channels; Work; abstracting; biological signal transduction; cost; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; extracellular; failure; gene product; high risk; hippocampal; human subject; in situ Hybridization Staining Method; inspiration; lymphogranulomatosis; lymphogranulomatosis (malignant); mRNA; mouse mutant; mutant; neurokinin 1; neuronal; neuronal excitability; novel; paralysis; paralytic; patch clamp; post-doc; post-doctoral; programs; protein function; receptor; recruit; research study; social role; sperm specific ion channel; vertebrata; voltage",Sodium Leak Channels and Regulation by Neurotransmitters,,55293,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,3,324822,
7754665,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS055658-03,,NINDS:336565;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PROVIDENCE,UNITED STATES,BIOCHEMISTRY,01,001785542,US,RI,02912,BROWN UNIVERSITY,"MCKEOWN, MICHAEL B;",1904105;,5R01NS055658,02/01/2008,01/31/2013,"Address; Alleles; Allelomorphs; Animal Welfare; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Bibliography; Biochemistry; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Cells; Cellular biology; Chemistry, Biological; Coagulation Factor I; Coagulation Factor One; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Complex; Country; Courtship; DNA Molecular Biology; Data; Drosophila; Drosophila genus; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Equipment; Ethics Committees, Research; Factor I; Factor One; Fecundability; Fecundity; Female; Fertility; Fibrinogen; Fruit Fly, Drosophila; Genes; Genes, Overlapping; Genes, Switch; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Human; Human, General; IACUC; IRBs; Impact, Environmental; Individual; Innate Behavior; Instinct; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Man (Taxonomy); Man, Modern; Maps; Mental Health; Mental Hygiene; Mind; Molecular Biology; Mutation; NRVS-SYS; Nature; Nervous; Nervous System; Nervous System Diseases; Nervous system structure; Neural Development; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neurologic Body System; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neurosciences; Overlapping Genes; Partner in relationship; Pattern; Phenotype; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Psychological Health; Published Comment; Research; Research Ethics Committees; Research Resources; Resources; Sex Behavior; Sexual Activity; Sexual Behavior; Switch Genes; System; System, LOINC Axis 4; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; base; behavioral control; cell biology; design; designing; experience; experiment; experimental research; experimental study; expiration; fruit fly; gene function; gene product; genome mutation; human subject; interest; knock-down; male; mate; mutant; nervous system disorder; neural; neurodevelopment; neurological disease; neuromuscular; programs; relating to nervous system; research study; response; sex; sex activity; trait; vertebrata",Dissatisfaction Retained and the Sex Behavior Network,,55658,ZRG1,Special Emphasis Panel,,3,336565,
7752776,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS055746-04,,NINDS:316022;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,PATHOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LIEBERMAN, ANDREW P;",2114395;,5R01NS055746,03/05/2007,01/31/2012,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; 21+ years old; APF-1; ATP-Dependent Proteolysis Factor 1; Abnormal Cell; Address; Adult; Affect; Alleles; Allelomorphs; Androgen Receptor; Animals; Atrophy, Muscle; Biochemical; CAG repeat; Cell Communication; Cell Interaction; Cell-to-Cell Interaction; Cells; Cessation of life; Chemotherapy-Hormones/Steroids; Chronic Disease; Chronic Illness; Code; Coding System; Core Facility; DNA Alteration; DNA mutation; Data; Death; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Development; Disease; Disorder; Disorder of muscle, unspecified; Dysfunction; Endocrine Gland Secretion; Environment; Exons; Functional disorder; Gene Alteration; Gene Mutation; Gene Targeting; Genes; Genetic; Genetic mutation; Glia; Glial Cells; Gln; Glutamine; Goals; HMG-20; High Mobility Protein 20; Hormonal; Hormones; Human, Adult; Impairment; Investigators; Kennedy Syndrome; Knock-in; Knock-in Mouse; Knowledge; Kolliker's reticulum; L-Glutamine; Laboratories; Lead; Length; Link; Macropain; Macroxyproteinase; Mammals, Mice; Mediating; Mice; Modeling; Modification; Molecular; Motor Cell; Motor Neuron Disease; Motor Neurons; Multicatalytic Proteinase; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Embryonic; Muscle Cells, Mature; Muscle Cells, Precursor; Muscle Disease; Muscle Disorders; Muscle Fibers; Muscle Tissue; Muscle disease or syndrome; Muscle satellite cell; Muscle, Skeletal; Muscle, Voluntary; Muscular Atrophy; Muscular Diseases; Myoblasts; Myocytes; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; Myotubes; NRVS-SYS; Nerve; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neuron Degeneration; Neuronopathy, Bulbospinal; Neurons; Non-neuronal cell; Outcome; Partner in relationship; Pathogenesis; Pathology; Pathway interactions; Patients; Pb element; Physiopathology; Play; Poly Q; Programs (PT); Programs [Publication Type]; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Proteosome; Public Health; Q. Levoglutamide; Receptor Gene; Receptor Protein; Research; Research Personnel; Researchers; Rhabdomyocyte; Role; Sequence Alteration; Severity of illness; Site; Skeletal Fiber; Skeletal Muscle Cell; Skeletal Muscle Fiber; Skeletal Muscle Tissue; Skeletal Myocytes; Skeletal muscle structure; Targetings, Gene; Testing; Therapeutic Hormone; Toxic effect; Toxicities; Transgenes; Ubiquitin; Work; X-Linked Bulbo-Spinal Atrophy; adult human (21+); base; cell type; chronic disease/disorder; chronic disorder; degenerative condition; degenerative disease; disease phenotype; disease severity; disease/disorder; effective therapy; gene product; heavy metal Pb; heavy metal lead; human disease; insight; male; mate; member; motoneuron; motor neuron degeneration; mouse model; multicatalytic endopeptidase complex; muscle regeneration; muscle stem cell; muscular disorder; mutant; nerve cement; neural degeneration; neurodegeneration; neurodegenerative illness; neuromuscular; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuronal toxicity; neurotoxicity; new therapeutic target; novel therapeutic intervention; pathophysiology; pathway; poly(glutamine); polyQ; polyglutamine; programs; protein degradation; public health medicine (field); receptor; receptor function; recombinase; regenerative; response; satellite cell; social role; spinal and bulbar muscular atrophy; ubiquitin ligase",Mechanisms of motor neuron toxicity in Kennedy Disease,,55746,CDIN,Cell Death in Neurodegeneration Study Section,,4,316022,
7743572,R01,NS,5,,12/01/2009,11/30/2010,PA-07-282,5R01NS055860-03,,NINDS:337838;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CINCINNATI,UNITED STATES,ANESTHESIOLOGY,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"ZHANG, JUN-MING ;",7751111;,5R01NS055860,12/15/2007,11/30/2012,"21+ years old; Accounting; Acute; Address; Adult; Affect; Afferent Neurons; Animal Welfare; Behavioral; Bibliography; Brain; Capacitance, Electrical; Cell Size; Cells; Chemicals; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Country; Cytokines, Chemotactic; Data; Development; Dorsal Root Ganglia; Drug Administration, Topical; Ecological impact; Editorial Comment; Editorial Comment (PT); Electric Capacitance; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Fiber; Figs; Figs - dietary; Fire - disasters; Fires; Frequencies (time pattern); Frequency; Ganglia; Ganglia, Spinal; Ganglion Cysts; Ganglionic Cysts; Ganglions; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; Herpes Zoster; Herpes zoster disease; Homologous Chemotactic Cytokines; Human, Adult; IACUC; INFLM; IRBs; Impact, Environmental; Incidence; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; International; Investigation; Investigators; Ion Channel; Ionic Channels; Ions; Mammals, Rats; Measures; Mechanics; Mediating; Medulla Spinalis; Membrane; Membrane Channels; Methods; Modeling; Myxoid cyst; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Ganglion; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Pain; Painful; Pathologic; Peripheral; Peripheral Nerves; Peripheral nerve injury; Physiologic; Physiological; Play; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Published Comment; Rat; Rattus; Receptor Protein; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Rupture; SIS cytokines; Screening procedure; Sensory Cell Afferent Neuron; Shingles; Spinal Cord; Spinal Ganglia; Suggestion; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Topical application; Up-Regulation; Up-Regulation (Physiology); Upregulation; V (voltage); Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Viral Diseases; Virus Diseases; Work; Writing; Zona; Zoster; abstracting; adult human (21+); base; capacitance; cell type; chemoattractant cytokine; chemokine; chronic pain; chronic painful condition; cytokine; density; design; designing; dorsal root ganglion; experiment; experimental research; experimental study; expiration; herpes zona; human subject; improved; in vivo; interdisciplinary approach; interest; irritation; membrane structure; nerve injury; neural; neural injury; neuronal; novel; pain behavior; programs; receptor; relating to nervous system; research study; response; screening; screenings; social role; topical administration; topical drug application; topically applied; vertebrata; viral infection; virus infection; voltage; voltage clamp",NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN,,55860,SCS,Somatosensory and Chemosensory Systems Study Section,,3,337838,
7760630,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS055876-04,,NINDS:334590;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"HASHIMOTO, TOMOKI ;",7859112;,5R01NS055876,02/01/2007,01/31/2011,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; 92-kDa Gelatinase; 92-kDa Type IV Collagenase; Aneurysm; Animal Model; Animal Models and Related Studies; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Pressure, High; Blood Segmented Neutrophil; Blood Vessels; Blood flow; Bone Marrow Transplant; Bone Marrow Transplantation; Caliber; Cells; Cerebral Arterial Circle; Circle of Willis; Common carotid artery; Coupled; Data; Development; Diameter; Dimensions; Disease model; Esteroproteases; Future; Gelatinase A; Gelatinase B; Gelatinase Neutrophil; Generalized Growth; Genetic; Grafting, Bone Marrow; Growth; Heterophil Granulocyte; Human; Human, General; Hypertension; INFLM; Incidence; Infiltration; Inflammation; Inflammatory; Inhibition of Matrix Metalloproteinases; Inhibition of Matrix Metalloproteinases Pathway; Intracranial Aneurysm; Investigators; Knockout Mice; Link; Lymphocyte; Lymphocytic; MMP-2; MMP-9; MMP-9 Protein; MMP2; MMP9; MMPs; Macrophage Gelatinase; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow Transplantation; Matrix Metalloproteinase-2; Matrix Metalloproteinase-9; Matrix Metalloproteinases; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Murine; Mus; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PEX; Pathogenesis; Patients; Peptidases; Peptide Hydrolases; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Programs (PT); Programs [Publication Type]; Proteases; Proteinases; Proteolytic Enzymes; Research Personnel; Researchers; Risk; Rodent; Rodentia; Rodentias; Role; Rupture; Stress; Surgical; Surgical Interventions; Surgical Procedure; Thick; Thickness; Tissue Growth; Type V Collagenase; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular remodeling; Wild Type Mouse; angiogenesis; base; cytokine; disorder model; experiment; experimental research; experimental study; hemodynamics; high risk; hyperpiesia; hyperpiesis; hypertensive disease; lymph cell; macrophage; model organism; neutrophil; new therapeutic target; ontogeny; prevent; preventing; primary outcome; programs; proteinase In; research study; response; secondary outcome; social role; surgery; therapeutic target; vascular",Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation,,55876,BINP,Brain Injury and Neurovascular Pathologies Study Section,,4,334590,
7753159,R01,NS,5,,01/01/2010,12/31/2010,PA-07-198,5R01NS055916-03,,NINDS:536204;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,PATHOLOGY,01,053284659,US,PA,191075587,THOMAS JEFFERSON UNIVERSITY,"SCHNEIDER, JAY S;",1891138;,5R01NS055916,01/15/2008,12/31/2012,"(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid; (--)-3-(3,4-Dihydroxyphenyl)-L-alanine; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3,4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 3-Hydroxy-L-tyrosine; 4-(2-Aminoethyl)-1,2-benzenediol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5HT; ABT-418; AD/HD; ADHD; Acetylcholine; Acetylcholine Agents; Address; Adrenergic Agents; Adrenergic Agonists; Adrenergic Drugs; Adrenergic Receptor; Adrenergic Receptor Agonist; Adrenergics; Adrenoceptors; Adrenomimetics; Adverse effects; Affect; Age; Age-Years; Agents, Nicotinic; Aging; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Aminalon; Aminalone; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Animal Welfare; Animals; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Attentional deficit; Behavioral; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-; Bibliography; Biological Models; Brain region; Butanoic acid, 4-amino-; Cholinergic Agents; Cholinergic Agonists, Nicotinic; Cholinergic Drugs; Cholinergic Receptors; Cholinergics; Cholinoceptive Sites; Cholinoceptors; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Clonidine; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Corpus Striatum; Corpus striatum structure; Country; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Disturbance in cognition; Dopamine; Dose; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Therapy; Drug usage; Drugs; Dysfunction; Ecological impact; Editorial Comment; Editorial Comment (PT); Endogenous Opiates; Enteramine; Environment; Environmental Impact; Equipment; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethics Committees, Research; Expression Profiling; Expression Signature; Functional disorder; GABA; GTS-21; Glutamates; Guanfacine; Health; Hippophaine; Human; Human, General; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; IACUC; IRBs; Idiopathic Parkinson Disease; Impact, Environmental; Impaired cognition; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Klofenil; L-3,4-Dihydroxyphenylalanine; L-Dopa; L-Glutamate; Laboratories; Lead; Levarterenol; Levodopa; Levonorepinephrine; Lewy Body Parkinson Disease; Literature; Macaca mulatta; Man (Taxonomy); Man, Modern; Medication; Memory; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental disorders; Mental health disorders; Model System; Modeling; Models, Biologic; Molecular Fingerprinting; Molecular Profiling; Monkeys; Nature; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Neural Cell; Neurochemistry; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurological; Neurons; Neuroses, Post-Traumatic; Neuroses, Posttraumatic; Neurotoxins; Neurotransmitters; Nicotine; Nicotinic Acetylcholine Receptors; Nicotinic Agents; Nicotinic Agonists; Nicotinic Receptors; Noradrenaline; Norepinephrine; Older Population; Opiate Peptides; Opioid Peptide; PTSD; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Pathology; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Physiopathology; Population; Post-Traumatic Stress Disorders; Preclinical Testing; Primary Parkinsonism; Primary Senile Degenerative Dementia; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Published Comment; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; QOL; Quality of life; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Receptors, Epinephrine; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk Factors; Sampling; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Science of neurochemistry; Screening procedure; Senescence; Serotonin; Short-Term Memory; Staging; Stress Disorders, Post-Traumatic; Stress Disorders, Posttraumatic; Striate Body; Striatum; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Agents; Therapeutic Effect; Time; Treatment Efficacy; Treatment Side Effects; Unspecified Mental Disorder; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; acetylcholine receptor agonist; adenoreceptor; adult animal; adult youth; age dependent; age effect; age related; aged; aging effect; aging population; anatomy; attention deficit hyperactive disorder; base; behavioral pharmacology; beta-(3,4-Dihydroxyphenyl)-L-alanine; brain behavior; cholinergic; clinical investigation; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; comparative efficacy; dementia of the Alzheimer type; dementia praecox; design; designing; disease/disorder; drug discovery; drug efficacy; drug use; drug/agent; early onset; economic impact; effective therapy; elderly patient; endogenous opioid; executive control; executive function; expiration; gamma-Aminobutyric Acid; healthy volunteer; heavy metal Pb; heavy metal lead; human subject; improved; insight; juvenile animal; mature animal; mental illness; model organism; molecuar profile; molecular signature; neural; neurobehavioral; neurochemistry; neurodegenerative illness; neuronal; neurotoxicant; non-human primate; nonhuman primate; normal aging; novel; older patient; pathological aging; pathophysiology; preclinical study; primary degenerative dementia; programs; psychological disorder; receptor; receptor expression; relating to nervous system; response; restorative treatment; schizophrenic; screening; screenings; senescent; senile dementia of the Alzheimer type; side effect; striatal; therapeutic efficacy; therapeutic target; therapeutically effective; therapy adverse effect; traumatic neurosis; treatment adverse effect; treatment strategy; vertebrata; working memory; young adult; young animal",Attention and Executive Functioning in Aging and Parkisonism,,55916,CND,Clinical Neuroscience and Disease Study Section,,3,536204,
7766923,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS055963-03,,NINDS:329176;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAINT LOUIS,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"YABLONSKIY, DMITRIY A;",6622019;,5R01NS055963,02/01/2008,01/31/2013,"Address; Agreement; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Analysis, Data; Animal Model; Animal Models and Related Studies; Animal Welfare; Apoplexy; Applications Grants; Arteries; Attention; Au element; Base of the Brain; Bibliography; Blood; Blood Sample; Blood Vessels; Blood Volume; Blood capillaries; Blood flow; Blood specimen; Body Tissues; Bp50; Brain; Brain Diseases; Brain Disorders; Brain Drains; Brain Neoplasia; Brain Neoplasms; Brain Tumors; CD40; CDW40; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Moyamoya Disease; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Cognitive; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Country; Data; Data Analyses; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependency; Dependency (Psychology); Diagnosis, clinical; Diffusion; Disease; Disorder; Doctor of Medicine; Dysfunction; Ecological impact; Editorial Comment; Editorial Comment (PT); Electromagnetic Radiation, Ionizing; Encephalon; Encephalon Diseases; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Functional disorder; Funding; Goals; Gold; Grant Proposals; Grants, Applications; Health; Heterogeneity; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Hydrogen Oxide; Hypoxia; Hypoxic; IACUC; IRBs; Idiopathic Parkinson Disease; Image; Impact, Environmental; Impairment; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigation; Investigators; Ionizing radiation; Lead; Lewy Body Parkinson Disease; Literature; M.D.; MGC9013; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetism; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Math Models; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Positron Emission Tomography; Methods; Methods and Techniques; Methods, Other; Mice; Microscopic; Modality; Modeling; Modification; Molecular; Moya-Moya Disease; Moyamoya Disease; Moyamoya Syndrome; Murine; Mus; NMR Imaging; NMR Tomography; Nature; Nervous System Diseases; Nervous System, Brain; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Noise; Nuclear Magnetic Resonance Imaging; O element; O2 element; Organ; Oxygen; Oxygen Deficiency; PET; PET Scan; PET imaging; PETSCAN; PETT; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathologic; Patients; Pb element; Phlebotomy; Physiopathology; Play; Positron Emission Tomography Scan; Positron-Emission Tomography; Predisposition; Primary Parkinsonism; Primary Senile Degenerative Dementia; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Progressive Chorea, Hereditary, Chronic (Huntington); Progressive Intracranial Occlusive Arteropathy (Moyamoya); Proton Magnetic Resonance Spectroscopic Imaging; Published Comment; Quantitative Evaluations; Rad.-PET; Radiation-Ionizing Total; Rare Diseases; Rare Disorder; Rat; Rattus; Recruitment Activity; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Rest; Reticuloendothelial System, Blood; Role; Sagittal Sinus; Signal Transduction; Signal Transduction Systems; Signaling; Stroke; Structure; Study Section; Suggestion; Susceptibility; TNFRSF5; TNFRSF5 gene; Tag; Techniques; Time; Tissues; Tracer; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Validation; Vascular Accident, Brain; Vascular Diseases; Vascular Disorder; Venous; Venous blood sampling; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Visual; Water; Work; Zeugmatography; abstracting; base; biological signal transduction; blood vessel disorder; brain attack; brain tissue; capillary; cerebral blood flow; cerebral circulation; cerebral vascular accident; cerebrocirculation; clinical Diagnosis; clinical applicability; clinical application; clinical practice; dementia of the Alzheimer type; disease/disorder; emotional dependency; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; hemodynamics; human subject; imaging; in vivo; magnetic; mathematical model; mathematical modeling; member; model organism; nervous system disorder; neurological disease; p50; pathophysiology; primary degenerative dementia; programs; recruit; research study; senile dementia of the Alzheimer type; simulation; social role; stroke; tool; tumors in the brain; vascular; vertebrata; water diffusion",QUANTITATIVE BOLD CONTRAST IN HEALTH AND DISEASE,,55963,MEDI,Medical Imaging Study Section,,3,329176,
7760604,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS056086-03,,NINDS:324492;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,PHARMACOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"LI, LIMING ;",7604822;,5R01NS056086,02/01/2008,01/31/2013,"Anabolism; Analysis, Data; Animal Model; Animal Models and Related Studies; Animal Welfare; Anxiety; Bibliography; Bovine Spongiform Encephalopathy; CJD; CJDs (Creutzfeldt-Jakob Disease); Cells; Chaperone; Chronic Wasting Disease; Complex; Country; Creutzfeldt-Jacob Disease; Creutzfeldt-Jakob Disease; Creutzfeldt-Jakob Syndrome; Data Analyses; Ecological impact; Encephalitis, Bovine Spongiform; Encephalopathy, Bovine Spongiform; Endomycetales; Environment; Environmental Impact; Epidemic; Equipment; Ethics Committees, Research; Evaluation; Goals; HSP; Heat Shock; Heat shock proteins; Heat-Shock Reaction; Heat-Shock Response; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Jakob-Creutzfeldt Disease; Limes; Link; Mad Cow Disease; Maintenance; Maintenances; Methods; Molecular Chaperones; Molecular Configuration; Molecular Conformation; Molecular Stereochemistry; Outcome; PSI; Play; PrP Proteins; Principal Investigator; Prion Proteins; Prions; Production; Programs (PT); Programs [Publication Type]; Protein Structure Initiative; Proteins; Research; Research Ethics Committees; Research Resources; Resources; Role; S cerevisiae; Saccharomyces cerevisiae; Saccharomycetales; Spongiform Encephalopathy, Subacute; Stress; Stress Proteins; Suggestion; Testing; Variant; Variation; Vertebrate Animals; Vertebrates; Wasting Disease, Chronic; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; abstracting; base; biosynthesis; cell type; conformation; conformational state; experiment; experimental research; experimental study; expiration; gene product; human subject; interest; model organism; novel; programs; protein folding; research study; response; social role; vertebrata; yeast prion","Elucidating the Relations of Heat Shock Factors, Molecular Chaperones and Prions",,56086,CMND,Cellular and Molecular Biology of Neurodegeneration Study Section,,3,324492,
7755024,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS056176-05,,NINDS:350872;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BANIK, NAREN L;",1882531;,5R01NS056176,08/15/2006,01/31/2011,"Acute; Acute Disease; Address; Adoptive Transfer; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Arm; Astrocytes; Astrocytus; Astroglia; Attenuated; Biochemical; Blood Coagulation Factor IV; Blotting, Western; C.I. solvent blue 38; CANP-I; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Ca++ element; Ca2+-Activated Protease; Calcium; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain; Cavia; Cell Death; Cell Death, Programmed; Cells; Cells, CD4; Central Nervous System; Cessation of life; Chemicals; Chronic; Clinical; Coagulation Factor IV; Common Rat Strains; Data; Death; Demyelinations; Desminase; Development; Disease; Disease Progression; Disease remission; Disorder; Dose; EAE; Electron Microscopy; Encephalomyelitis; Encephalomyelitis, Allergic; Event; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Factor IV; Glia; Glial Cells; Goals; Guinea Pigs; H and E; Hematoxylin and Eosin; Hematoxylin and Eosin Staining Method; IFN; INFLM; Immune; Immune Cell Activation; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunologic Diseases; Immunological Diseases; In Vitro; Incubated; Infiltration; Inflammation; Inflammatory; Interferons; Investigators; Kolliker's reticulum; Label; Laboratories; Lead; Length; Literature; Luxol Fast Blue MBS; Luxol fast blue; MS (Multiple Sclerosis); Mammals, Guinea Pigs; Mammals, Mice; Mammals, Rats; Mediating; Medulla Spinalis; Mice; Modeling; Molecular; Motor; Multiple Sclerosis; Murine; Mus; Myelin; Myelin Basic Proteins; Myeloencephalitis; Necrosis; Necrotic; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurological; Neuron Degeneration; Neurons; Non-neuronal cell; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Onset of illness; Palsy; Papain-Like Cysteine Protease; Paralysed; Pathway interactions; Pb element; Peptides; Play; Plegia; Polymers; Production; Programs (PT); Programs [Publication Type]; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Turnover; Proteins; Protocols, Treatment; Publishing; RGM; RMSN; Rat; Rattus; Recovery; Regimen; Relapse; Remission; Research Personnel; Researchers; Reticuloendothelial System, Spleen; Role; SJA-6017; SJA6017; SJL/J Mouse; Sclerosis, Disseminated; Severities; Severity of illness; Spectrin; Spinal Cord; Spleen; Staining method; Stainings; Stains; T-Cell Activation; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Tail; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Treatment Protocols; Treatment Regimen; Treatment Schedule; Up-Regulation; Up-Regulation (Physiology); Upper arm; Upregulation; Western Blotting; Western Blottings; Western Immunoblotting; acute disease/disorder; acute disorder; assault; attenuation; autoimmune encephalomyelitis; autoreactive T cell; axonal degeneration; base; calcium green; calcium-activated neutral protease inhibitor; calpain inhibitor; disability; disease onset; disease severity; disease/disorder; disorder onset; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; helper T cell; insular sclerosis; macrophage; methasol fast blue; migration; model organism; mouse model; necrocytosis; nerve cement; neural degeneration; neurodegeneration; neurofilament; neuronal; neuronal degeneration; novel; paralysis; paralytic; pathway; prevent; preventing; pro-apoptotic protein; programs; protein blotting; protein degradation; research study; social role; thymus derived lymphocyte",Attenuation of Axonal Damage and Neuronal Death in EAE,,56176,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,5,350872,
7765628,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS056218-05,,NINDS:369395;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,OKLAHOMA CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,878648294,US,OK,731171213,UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR,"SONNTAG, WILLIAM EDMUND;",1871245;,5R01NS056218,02/15/2007,01/31/2012,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol; ACE Inhibitors; ANG-(1-8)Octapeptide; Acetylcholine; Acquired brain injury; Adverse effects; After Care; After-Treatment; Aftercare; Age; Amentia; Ammon Horn; AngII; Angiotensin I-Converting Enzyme Inhibitors; Angiotensin II; Angiotensin-(1-8) Octapeptide; Angiotensin-Converting Enzyme Inhibitors; Animals; Antagonists, Angiotensin-Converting Enzyme; Anterior; Anxiety; Apoptosis; Apoptosis Pathway; Arterioles; Attenuated; Autoregulation; Blood - brain barrier anatomy; Blood Vessels; Blood capillaries; Blood-Brain Barrier; Brain; Brain Injuries; Brain Metastasis; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Brain region; Breast; Cancer Patient; Cancer of Breast; Cancer of Lung; Cancer of Prostate; Cancers; Capillaries; Capillary; Capillary, Unspecified; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Causality; Cell Death, Programmed; Cerebrovascular Circulation; Cerebrum; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Cornu Ammonis; Cranial Irradiation; Cyclopenta(b)pyrrole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-; D-Glucose; Dementia; Dentate Fascia; Dentate Gyrus; Development; Dextrose; Diagnosis; Disseminated Malignant Neoplasm; Disturbance in cognition; Doctor of Philosophy; Dose; Dysfunction; Effects of radiation; Electrolytes; Encephalon; Encephalons; Endothelial Cells; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Etiology; Fascia Dentata; Functional disorder; Functional impairment; Generations; Glia; Glial Cells; Glucose; Gyrus Dentatus; Hemato-Encephalic Barrier; Hippocampus; Hippocampus (Brain); Homeostasis; Hypoxia; Hypoxic; Impaired cognition; Impairment; Incidence; Injury; Investigators; Kidney; Kininase II Antagonists; Kininase II Inhibitors; Kolliker's reticulum; LTS; Lead; Learning; Liquid substance; Long-Term Survivors; Losartan; Lung; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Lung; Malignant Tumor of the Prostate; Malignant neoplasm of breast; Malignant neoplasm of lung; Malignant neoplasm of prostate; Malignant prostatic tumor; Measures; Memory; Metastatic Cancer; Metastatic Malignant Neoplasm; Metastatic Neoplasm to the Brain; Metastatic Tumor to the Brain; Metastatic malignant neoplasm to brain; Nervous System, Brain; Neuroglia; Neuroglial Cells; Neurologic Manifestations; Neurologic Signs and Symptoms; Neurological Manifestations; Newly Diagnosed; Non-neuronal cell; Organ; Organ System, Cardiovascular; Oxidative Stress; Oxygen Deficiency; Pain; Painful; Patients; Pb element; Perception; Ph.D.; PhD; Physiological Homeostasis; Physiopathology; Prevention strategy; Preventive strategy; Procedures; Process; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Protocol; Protocols documentation; Pulmonary Cancer; Pulmonary malignant Neoplasm; Radiation; Radiation induced damage; Ramipril; Rats, Norway; Rattus norvegicus; Receptor Protein; Renin-Angiotensin System; Research Personnel; Researchers; Respiratory System, Lung; Severities; Site; Stress; Structure of arteriole; Structure of dentate gyrus; Structure of venule; Survivors, Long-Term; System; System, LOINC Axis 4; Testing; Time; Treatment Efficacy; Treatment Side Effects; Urinary System, Kidney; VEGFs; Vascular Endothelial Growth Factors; Vascular, Heart; Vegf; Venules; age dependent; age related; arteriole; base; brain damage; brain irradiation; brain lesion (from injury); brain radiation; capillary; cerebral blood flow; cerebral circulation; cerebrocirculation; cerebrovascular; cingulate cortex; circulatory system; clinical relevance; clinically relevant; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cranial radiation; density; dentate gyrus; disease causation; disease etiology; disease/disorder etiology; disorder etiology; effect, adverse, radiation; fluid; functional disability; glucose metabolism; heavy metal Pb; heavy metal lead; hippocampal; improved; innovate; innovation; innovative; irradiation; liquid; lozartan; lung cancer; malignancy; malignant breast neoplasm; melanoma; mid life; mid-life; middle age; middle aged; midlife; neoplasm/cancer; nerve cement; neural manifestation; paracrine; pathophysiology; prevent; preventing; programs; pulmonary; radiation effect; ray (radiation); receptor; renal; response; side effect; therapeutic efficacy; therapeutically effective; therapy adverse effect; treatment adverse effect; tumors in the brain; vascular; venule",Effects of Radiation on Brain Microvasculature and Cognition,,56218,CND,Clinical Neuroscience and Disease Study Section,,5,369395,
7758267,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS056314-03,,NINDS:243877;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLUMBIA,UNITED STATES,BIOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"SMITH, DEANNA S;",1909137;,5R01NS056314,01/01/2008,12/31/2011,"21+ years old; Adenosine Triphosphatase, Dynein; Adult; Affect; Animal Welfare; Assay; Axon; Bibliography; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Brain; Cell Locomotion; Cell Migration; Cell Movement; Cells; Cellular Migration; Childhood; Country; Data; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equipment; Ethics Committees, Research; Genetic Alteration; Genetic Change; Genetic defect; Goals; Human, Adult; IACUC; IRBs; Immigrations; Impact, Environmental; In Vitro; In-Migration; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intractable Epilepsy; Italy; LIS-1 protein; LIS1 protein; Lead; Ligand Binding Protein; Link; Literature; Lysosomes; M Phase; M phase (cell cycle); Mammals, Mice; Measures; Mice; Micro-tubule; Microtubules; Missense Mutation; Mitosis; Mitosis Stage; Mitotic; Motility; Motility, Cellular; Motor; Murine; Mus; Mutation; Mutation, Missense; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neurons; Organelles; Pb element; Phenotype; Principal Investigator; Programs (PT); Programs [Publication Type]; Proteins; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Role; Seizure Disorder; Seizures; Testing; Vertebrate Animals; Vertebrates; abstracting; adult human (21+); base; cell motility; disease/disorder; dynein ATP phosphohydrolase (tubulin translocating); epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; gene product; genome mutation; heavy metal Pb; heavy metal lead; human subject; in vivo; lissencephaly; lissencephaly protein; lissencephaly-1; mutant; neglect; neurodegenerative illness; neuronal; novel; overexpression; pediatric; programs; receptor; research study; social role; trafficking; vertebrata","Examining the role of the Lissencephaly Protein, Lis1, in Dynein-Based Transport",,56314,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,3,243877,
7765531,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS056315-02,,NINDS:363826;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,ANESTHESIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"HEMMINGS, HUGH C;",1876212;,5R01NS056315,02/15/2009,01/31/2014,"ATP phosphohydrolase (Na+ K+ transporting); ATP-protein phosphotransferase; Address; Ammon Horn; Apoptosis; Apoptosis Pathway; Apoptotic; Asystole; Attention; Attenuated; Brain; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium/calmodulin-dependent protein kinase; Canine Species; Canis familiaris; Cardiac Arrest; Care, Health; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Culture Techniques; Cell Death; Cell Death Process; Cell Death, Programmed; Cell Function; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellular Regulation; Cellular injury; Cerebral Ischemia; Cessation of life; Chromatography, Gas-Liquid-Mass Spectrometry; Clinical; Co-Immunoprecipitations; Complex; Cornu Ammonis; D-Glucose; Death; Development; Dextrose; Dogs; EC 1.14.13.39; EDRF Synthase; Encephalon; Encephalons; Endothelium-Derived Growth Factor Synthase; Enzymes; Esteroproteases; Family suidae; Fore-Brain; Forebrain; Foundations; GC MS; GCMS; Glucose; Glutamate Receptor; Glutamates; Goals; Guanylyl Cyclase-Activating Factor Synthase; H2O2; Healthcare; Heart Arrest; Hippocampus; Hippocampus (Brain); Holoenzymes; Hour; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Impairment; In Vitro; Intracellular Communication and Signaling; Intracellular Second Messengers; Ischemia; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-Glutamate; Lead; Link; MALD-MS; MALDI; MALDI-MS; Mammals, Dogs; Mass Fragmentographies; Mass Fragmentography; Mass Spectrum; Mass Spectrum Analysis; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Medical Economics; Membrane; Modeling; Molecular; N Methyl D aspartic Acid; N element; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; N2 element; NADPH-Diaphorase; NIPP-1; NIPP1 protein; NMDA; NO Synthase; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Na+ K+ ATPase; Necrosis; Necrotic; Nerve Cells; Nerve Unit; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous System, Brain; Neural Cell; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurocyte; Neurologic; Neurological; Neurological Damage; Neurological Injury; Neurological trauma; Neurons; Nitric Oxide Synthase; Nitric-Oxide Synthetase; Nitrogen; O element; O2 element; Oxygen; PKC; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Phosphatases; Phosphohydrolases; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Photometry/Spectrum Analysis, Mass; Physiologic; Physiological; Pigs; Play; Potassium Pump; Property; Property, LOINC Axis 2; Prosencephalon; Proteases; Protein Kinase; Protein Kinase C; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein Serine/Threonine Phosphatase; Protein phosphatase; Proteinases; Proteins; Proteolytic Enzymes; Proteomics; Reagent; Regulation; Regulatory Protein; Reperfusion Therapy; Research Proposals; Resuscitation; Role; Scaffolding Protein; Second Messenger Systems; Second Messengers; Shotguns; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Simulate; Site; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump; Specificity; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrometry, Mass-Gas Chromatography; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Spectrum Analysis, Mass-Gas Chromatography; Subcellular Process; Suidae; Swine; Testing; Translations; Trauma, Nervous System; V (voltage); base; biological signal transduction; brain cell; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; canine; cell damage; cell growth regulation; cell injury; deprivation; design; designing; domestic dog; economic impact; excitotoxicity; experiment; experimental research; experimental study; gene product; genetic regulatory protein; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; hippocampal; hydroxyalkyl protein kinase; in vivo; inhibitor; inhibitor/antagonist; ion trap mass spectrometry; mass fragmentometry; matrix assisted laser desorption ionization; member; membrane structure; microtubule associated protein 2 kinase; necrocytosis; neuronal; novel; nuclear inhibitory polypeptide of protein phosphatase-1; pathway; phosphatase inhibitor 1; phosphorylase b kinase kinase; porcine; prevent; preventing; protein kinase II; protein phosphatase inhibitor-1; public health relevance; reconstitute; reconstitution; regulatory gene product; reperfusion; research study; response; second messenger; serine-threonine phosphatase; small molecule; social; social role; sodium potassium exchanging ATPase; suid; tandem mass spectrometry; therapeutic target; voltage",Role of Protein Phosphatase-1 in Cerebral Ischemia and Cell Death," Narrative Global cerebral ischemia due to cardiac arrest results in debilitating neurological impairment necessitating costly long-term health care. Despite an immense social, medical and economic impact, there is currently no specific pharmacological therapy. The proposed studies will elucidate physiological and pathophysiological mechanisms that regulate native protein phosphatase-1 holoenzymes in brain and determine their role in the control of cell death in global cerebral ischemia. This approach is targeted to the development of rational mechanism-based protein phosphatase-1 inhibitors to attenuate ischemic cell death and neurological injury.",56315,BINP,Brain Injury and Neurovascular Pathologies Study Section,,2,363826,
7760184,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS056415-03,,NINDS:291060;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,AUGUSTA,UNITED STATES,NEUROLOGY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"MEI, LIN ;",8134896;,5R01NS056415,04/01/2008,01/31/2012,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; APC - Adenomatous Polyposis Coli; Abbreviations; Acetyl-CoA[{..}]choline O-acetyltransferase; Acetylcholine; Ache; Actins; Action Potentials; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli, Familial; Adenomatous Polyposis of the Colon; Anatomic structures; BDNF; Bioniche Brand of Carbachol; Blood Coagulation Factor IV; Brain-Derived Neurotrophic Factor; Bungarotoxins; CAAX geranylgeranyl transferase; Ca++ element; CaM KII; CaM PK II; CaM kinase II; CaMK; CaMKII; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium/calmodulin-dependent protein kinase; Carbachol; Carbacholine; Carbocholine; Cats; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Characteristics; Chemical Synapse; Choline Acetylase; Choline Acetyltransferase; Choline O-Acetyltransferase; Coagulation Factor IV; Complex; Congenital Myasthenic Syndromes; Defect; Development; Diagnostic; Disease; Dislocations; Disorder; Docking; Domestic Cats; Dysfunction; EC 1.14.13.39; EDRF Synthase; Electrons; Endothelium-Derived Growth Factor Synthase; Ester Hydrolase; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Exhibits; Factor IV; Familial Adenomatous Polyposis Syndrome; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Fluorescence; Frequencies (time pattern); Frequency; Functional disorder; GDNF; GDNF gene; GGTase-I; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genetic Intervention; Geranylgeranyl Transferase; Geranylgeranyltransferase Type I; Glycogen Synthase Kinases; Goals; Guanylyl Cyclase-Activating Factor Synthase; Hereditary Adenomatous Polyposis Coli; Human; Human, General; Intervention, Genetic; Intracellular Communication and Signaling; Ion Channels, Calcium; JN Kinase; JNK; JNK Mitogen-Activated Protein Kinases; JNK1; JNK1 Kinase; JNK1 protein; JNK1A2; JNK21B1/2; Joint Dislocation; Knock-out; Knockout; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); LEF Transcription Factor; Laboratories; Lymphoid Enhancer Factor; MAP Kinase 8; MAP Kinase 8 Gene; MAPK8; MAPK8 Mitogen-Activated Protein Kinase; MAPK8 gene; MGC34632; MUSK protein, human; MUSK receptor, human; Maintenance; Maintenances; Mammals, Cats; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Mice; Mice, Mutant Strains; Microarray Analysis; Microarray-Based Analysis; Microscopic; Mitogen-Activated Protein Kinase 8; Modeling; Molecular; Molecular Biology, Gene Therapy; Morphology; Motor Cell; Motor Neurons; MuSK kinase; Murine; Mus; Muscle; Muscle Cells; Muscle Cells, Mature; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Mutant Strains Mice; Myasthenia Gravis, Congenital; Myasthenic Syndromes, Congenital; Myocytes; Myoneural Junction; NADPH-Diaphorase; NO Synthase; Negative Beta Particle; Negatrons; Nerve; Nerve Impulse Transmission; Nerve Transmission; Nervous; Nervous System, CNS; Neuraxis; Neuromuscular Diseases; Neuromuscular Junction; Neuronal Transmission; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nitric Oxide Synthase; Nitric-Oxide Synthetase; NutraMax Brand of Carbachol; PKC; PRKM8; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phrenic Nerve; Physiologic pulse; Physiopathology; Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial; Protein Kinase C; Proteins; Pulse; Receptors, Calcium Channel Blocker; Recycling; Rhodamine; Rhodamines; Role; SAP Kinase-1; SAPK/JNK; SAPK1; SAPK1 Mitogen-Activated Protein Kinase; SAPK1/JNK; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; Structure of phrenic nerve; Synapses; Synaptic; Synaptic Membranes; T Cell Factor; TCF Transcription Factor; Techniques; Testing; Therapy, DNA; Transmission; VDCC; VESCL; Vesicle; Voltage-Dependent Calcium Channels; Xenopus; biological signal transduction; c-jun Amino-Terminal Kinase; c-jun Kinase-1; c-jun N-Terminal Kinase; c-jun N-Terminal Kinase 1; calcium-calmodulin-dependent PK; calcium-calmodulin-dependent PK type II; calcium-dependent CaM kinase II; calmodulin dependent protein kinase; calmodulin-dependent protein kinase II; cholinergic synapse; disease/disorder; esterase; experiment; experimental research; experimental study; familial adenomatous polyposis; familial polyposis; gene product; gene therapy; genetic therapy; geranylgeranyl-protein transferase type 1; geranylgeranyltransferase I; glial cell-line derived neurotrophic factor; human MUSK protein; jun-NH2-Terminal Kinase; microarray technology; microtubule associated protein 2 kinase; motoneuron; mouse mutant; muscle-specific kinase MuSK; mutant; myoneural disorder; neuromuscular; neuromuscular disorder; neurotransmission; pathophysiology; presynaptic; protein GGTase; protein expression; protein geranylgeranyltransferase; protein kinase II; ras protein GG transferase; ras protein geranylgeranyltransferase; research study; response; skeletal; social role; stress-activated protein kinase 1; tool; transmission process",Neuromuscular Junction Formation,,56415,SYN,"Synapses, Cytoskeleton and Trafficking Study Section",,3,291060,
7760535,R01,NS,5,,02/01/2010,01/31/2011,PA-04-006,5R01NS056443-05,,NINDS:397735;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,PHYSIOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"NITABACH, MICHAEL NATHAN;",8263930;,5R01NS056443,08/02/2006,01/31/2011,"Affect; Affinity; Animal Model; Animal Models and Related Studies; Animals; Behavior Control; Behavioral; Behavioral Manipulation; Biological Models; Brain; Cell membrane; Cells; Chimera Protein; Chimeric Proteins; Circadian Rhythms; Communities; Cytoplasmic Membrane; Development; Development and Research; Disease; Disorder; Diurnal Rhythm; Drosophila; Drosophila genus; Drosophila melanogaster; Dysfunction; Economics; Encephalon; Encephalons; FTX, spider toxin; Family; Flies; Fruit Fly, Drosophila; Functional disorder; Fusion Protein; GeneHomolog; Genetic Enhancement; Genomics; Goals; Health; Homolog; Homologous Gene; Homologue; Hour; Human; Human, General; In Vitro; Insecta; Insects; Internet; Invertebrates, Insects; Investigators; Ion Channel; Ion Channels, Potassium; Ionic Channels; Ions; K channel; Libraries; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Membrane; Membrane Channels; Model System; Models, Biologic; Molecular; Molecular Target; NIH; NRVS-SYS; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurobiology; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuromediator Receptors; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Nyctohemeral Rhythm; Pain; Painful; Peptides; Phenotype; Physiologic; Physiological; Physiopathology; Plasma Membrane; Potassium Channel; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteomics; R & D; R&D; Reagent; Receptors, Neurohumor; Refractory; Research; Research Personnel; Researchers; Rest; Role; Screening procedure; Side; Source; Specificity; Spiders; Structure; TRP channel; TRP protein; Technology; Testing; Toxin; Transgenic Organisms; Twenty-Four Hour Rhythm; United States National Institutes of Health; Venoms; Vertebrate Animals; Vertebrates; WWW; base; behavioral control; channel blockers; circadian; circadian process; combinatorial; daily biorhythm; disease/disorder; diurnal variation; extracellular; fly; fruit fly; funnel web spider toxin; funnel-web spider venom; in vivo; ion channel blocker; member; membrane structure; model organism; neural circuit; neural circuitry; neurobiological; neuronal; neurotechnology; new technology; novel; pathophysiology; plasmalemma; programs; research and development; response; sFTX; screening; screenings; social role; spider toxin FTX; transgenic; vertebrata; web; world wide web",Transgenic Tethered Spider Toxins,,56443,ZRG1,Special Emphasis Panel,,5,397735,
7760589,R01,NS,5,,02/01/2010,01/31/2011,HL-05-004,5R01NS056485-05,,NINDS:275050;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"STRITTMATTER, STEPHEN M;",1876743;,5R01NS056485,02/15/2006,01/31/2011,"21+ years old; Ablation; Acquired brain injury; Address; Adult; After Care; After-Treatment; Aftercare; Animals; Apoplexy; Binding; Binding (Molecular Function); Blood flow; Brain; Brain Injuries; Brain Ischemia; Cell Communication and Signaling; Cell Signaling; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chimera Protein; Chimeric Proteins; Clinical; Common Rat Strains; Complex; DNA Sequence Rearrangement; Data; Development; Dose; Effectiveness; Encephalon; Encephalons; Fc Receptor; FcR; Fiber; Functional impairment; Fusion Protein; Gene Targeting; Genetic; Human, Adult; Infarction; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Ischemia; Ischemic Encephalopathy; Ischemic Stroke; Knowledge; Ligands; Mammals, Mice; Mammals, Rats; Maps; Mechanics; Mediating; Medulla Spinalis; Methods; Mice; Middle Cerebral Artery Occlusion; Modeling; Molecular; Molecular Interaction; Murine; Mus; Myelin; Myelin Proteins; Myelopathy, Traumatic; NI-220 protein; NI-250 protein; NI-35 protein; NI-35-250; Natural regeneration; Nerve Cells; Nerve Fibers; Nerve Unit; Nervous System Physiology; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic; Neurologic Deficit; Neurologic function; Neurological; Neurological function; Neurons; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Nogo protein; Nogo-A protein; Nogo-B protein; Nogo-C protein; Occlusion, Middle Cerebral Artery; Pathway interactions; Play; Rat; Rattus; Rearrangement; Receptor Protein; Recovery; Recovery of Function; Regeneration; Role; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stroke; System; System, LOINC Axis 4; Targetings, Gene; Therapeutic; Trauma; Vascular Accident, Brain; Work; adult human (21+); adult youth; age dependent; age effect; age related; aging effect; antibody receptor; axon growth; axon regeneration; axonal growth; axonal regeneration; axonal sprouting; base; biological signal transduction; brain attack; brain damage; brain lesion (from injury); brain tissue; cerebral vascular accident; disability; experiment; experimental research; experimental study; functional disability; functional recovery; improved; in vivo; infarct; inhibitor; inhibitor/antagonist; interventional strategy; nervous system function; neurite growth inhibitor 35-350; neuronal; neuroprotection; pathway; receptor; receptor function; regenerate; research study; response; rho; small molecule; social role; stroke; stroke recovery; success; young adult",Nogo Receptor Antagonist for Ischemic Stroke Recovery,,56485,ZHL1,Special Emphasis Panel,,5,275050,
7763199,R01,NS,5,,02/01/2010,01/31/2011,PAR-07-352,5R01NS057128-02,,NINDS:573211;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,LOS ANGELES,UNITED STATES,BIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"BAUDRY, MICHEL ;",1905444;,5R01NS057128,02/02/2009,01/31/2013,"Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Aminoacetic Acid; Ammon Horn; Apical; Back; Basic Research; Basic Science; Bio-Informatics; Bioinformatics; Biological; Biological Models; Biomedical Engineering; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; California; Coagulation Factor IV; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Collaborations; Communication; Complex; Computer Simulation; Computerized Models; Connector Neuron; Cornu Ammonis; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Disturbance in cognition; Dorsum; Dose; Drug Combinations; Drugs; Elements; Encephalon; Encephalons; Environment; Epilepsy; Epileptic Seizures; Epileptics; Event; Factor IV; Frequencies (time pattern); Frequency; GABA Receptor; Glutamates; Glycine; Goals; Head; Hippocampal Formation; Hippocampus; Hippocampus (Brain); Impaired cognition; In Vitro; Individual; Information Storage; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Second Messengers; Ion Channels, Potassium; Jobs; K channel; L-Glutamate; Learning; Life; Link; Long-Term Potentiation; Math Models; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Memory; Memory Deficit; Memory impairment; Metabotropic Glutamate Receptors; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Models, Computer; Models, Molecular; Modification; Molecular; Molecular Models; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NRVS-SYS; Names; Nerve Cells; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Transmission; Neurocyte; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurons; Nucleic Acid Biochemistry, Molecular Modeling; Occupations; Output; Pathway interactions; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacological Treatment; Physiologic pulse; Potassium Channel; Primary Senile Degenerative Dementia; Principal Investigator; Process; Professional Postions; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein/Amino Acid Biochemistry, Molecular Modeling; Pulse; Pyramidal Cells; Pyramidal neuron; Receptor Protein; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Receptors, gamma-Aminobutyric Acid; Research; Role; Scientist; Second Messenger Systems; Second Messengers; Seizure Disorder; Simulation, Computer based; Site; Slice; Spinal Column; Spine; Storage, Data; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic; Theta Rhythm; Training; Translating; Translatings; Universities; Validation; Vertebral column; Work; backbone; base; bioengineering; bioengineering/biomedical engineering; cholinergic; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; dementia of the Alzheimer type; desensitization; design; designing; disease/disorder; drug efficacy; drug/agent; efficacy testing; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; hippocampal; hippocampal pyramidal neuron; improved; in silico; inhibitory neuron; language translation; mathematical model; mathematical modeling; models and simulation; molecular modeling; network models; neuronal; neuropsychiatric; neuropsychiatry; new technology; pathway; postsynaptic; primary degenerative dementia; programs; public health relevance; receptor; reconstruction; research study; response; second messenger; senile dementia of the Alzheimer type; simulation; social role; tool; virtual simulation",Simulation of learning: models and biological validation," Principal Investigator/Program Director (Last, First, Middle): Baudry, Michel Project Narrative Learning and memory impairments are important aspects of numerous neurological and neuropsychiatric diseases. Identifying new pharmacological treatments for cognitive impairment is both urgent and difficult in view of the complexity of the mechanisms involved in memory formation. The proposed work is directed at developing bioinformatics tools to facilitate this process by providing a better understanding of the molecular and cellular events participating in memory formation as well as a platform for testing the efficacy of drugs or combination of drugs for improving memory formation.",57128,ZRG1,Special Emphasis Panel,,2,573211,
7767664,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS057338-03,,NINDS:360209;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"SCHNAAR, RONALD L;",1888787;,5R01NS057338,03/01/2008,02/28/2013,"Acylneuraminyl hydrolase; Animal Model; Animal Models and Related Studies; Astrocytes; Astrocytus; Astroglia; Axon; Behavior; Behavioral; Binding; Binding (Molecular Function); Biology; Brachial Plexus; Brachial plexus structure; Bruise; CNS Injury; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Central Nervous System; Central Nervous System Injury; Chondroitin ABC Lyase; Chondroitin Sulfate Proteoglycan; Chondroitinase ABC; Cicatrix; Common Rat Strains; Contusions; Critiques; Data; Environment; Enzymes; Evaluation; Family; Future; Gangliosides; Glycans; Human; Human, General; Implant; In Vitro; Infusion; Infusion procedures; Injury; Injury of central nervous system; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Intracellular Communication and Signaling; Knowledge; Label; Lecithinase C; Life; Locomotor Recovery; MAG Protein; MOG glycoprotein; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Modeling; Molecular; Molecular Interaction; Molecular Target; Molecular Weight; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motor Cell; Motor Neurons; Myelin; Myelin Associated Glycoprotein; Myelopathy, Traumatic; N-Acylneuraminate Glycohydrolases; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural regeneration; Nerve; Nerve Cells; Nerve Unit; Nervous; Nervous System, CNS; Neural Cell; Neuraminidase; Neuraxis; Neurocyte; Neurons; Oligosaccharide Sialidase; Organ System, Cardiovascular; Outcome; Peptides; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Phospholipase C; Physiologic; Physiological; Pleural Glycoproteins; Polysaccharides; PtdIns; Publishing; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reagent; Receptor Protein; Recovery; Recovery of Function; Reflex; Reflex action; Regeneration; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Residual; Residual state; Scars; Science of neurophysiology; Sialidase; Sialoglycoproteins; Sialoglycosphingolipids; Side; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Specificity; Spinal; Spinal Cord; Spinal Cord Contusions; Spinal Cord Trauma; Spinal Nerves; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Spinal nerve structure; Study Section; Testing; Therapeutic; Time; Treatment Efficacy; United States National Institutes of Health; Vascular, Heart; autonomic reflex; axon regeneration; axonal regeneration; base; behavior test; behavioral test; biological signal transduction; cell type; central nervous system injury; circulatory system; exo alpha sialidase; functional recovery; improved; in vivo; inhibitor; inhibitor/antagonist; injured; lipophosphodiesterase I; loss of function; model organism; motoneuron; myelin glycoprotein; myelin oligodendrocyte glycoprotein; nerve injury; neural injury; neuronal; neurophysiology; neurotrophic factor; neurotrophin; neutrophin; novel; oligodendrocyte-myelin glycoprotein; phosphatidylcholine cholinephosphohydrolase; preclinical study; receptor; regenerate; regenerative; sialoglycolipids; therapeutic development; therapeutic efficacy; therapeutic target; therapeutically effective",Targeting Endogenous Inhibitors to Enhance Spinal Axon Regeneration After Injury,,57338,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,3,360209,
7761315,R01,NS,5,,02/01/2010,01/31/2011,PAS-04-120,5R01NS057412-04,,NINDS:314016;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"BEDWELL, DAVID M;",1885237;,5R01NS057412,02/01/2007,01/31/2012,"Aminoglycosides; Animal Model; Animal Models and Related Studies; Assay; Bioassay; Biochemical; Biologic Assays; Biological Assay; Body Tissues; Categories; Decay, mRNA; Defect; Disease; Disorder; Ellis-Sheldon syndrome; European; Fibroblasts; Garamicin; Garamycin; Genes; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genoptic; Genoptic S.O.P.; Gentamicins; Glycosaminoglycan Degradation; Glycosaminoglycan Degradation Pathway; Glycosaminoglycan alpha-L-iduronohydrolase; Glycosaminoglycans; Hereditary Disease; Human; Human, General; Hurler Syndrome Gargoylism; Hurler syndrome; Hurler's Disease; Hurler's Syndrome; Iduronidase; Investigators; Johnie McL syndrome; Knock-in; Knock-in Mouse; Knowledge; L-Iduronidase; Lipochondrodystrophy; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; Lysosomes; MPS 1; MPS I; MPS I H; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Microscopic; Molecular Disease; Molecular Genetic; Molecular Genetics; Mucopolysaccharides; Mucopolysaccharidoses; Mucopolysaccharidosis; Mucopolysaccharidosis 1; Mucopolysaccharidosis I; Mucopolysaccharidosis I H; Murine; Mus; Mutation; Nonsense Mutation; Patients; Pfaundler-Hurler syndrome; Pharmacogenomics; Phenotype; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; RNA, Messenger; Research Personnel; Researchers; Testing; Tissues; Translations; U-Gencin; alpha-L-Idosiduronase; alpha-L-Iduronidase; alpha-L-iduronidase (IDA, IDUA) deficiency; alpha-L-iduronidase deficiency; base; chondro-osteodystrophy-corneal; disease phenotype; disease/disorder; dysostotic idiocy-gargoylism-lipochondrodystrophy syndrome; gargoylism; genetic disorder; genome mutation; hereditary disorder; iduronidase deficiency disease; in vivo; inborn lysosomal enzyme disorder; mRNA; mRNA Decay; model organism; mouse model; mucopolysaccharide storage disease I; mucopolysaccharidosis (MPS) I; mucopolysaccharidosis type I; new therapeutics; next generation therapeutics; novel therapeutics; opacities-hepatosplenomegaly mental deficiency syndrome; premature; prevent; preventing; programs; restoration; treatment strategy",Suppression of the Idua-W402X mutation in an MPS I-H mouse,,57412,ZRG1,Special Emphasis Panel,,4,314016,
7761309,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS057607-03,,NINDS:331341;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STORRS-MANSFIELD,UNITED STATES,BIOCHEMISTRY,02,614209054,US,CT,06269,UNIVERSITY OF CONNECTICUT STORRS,"O'NEILL, MICHAEL J;",6629630;,5R01NS057607,02/01/2008,01/31/2013,"2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3; Actinomycin A IV; Actinomycin C1; Actinomycin D; Actinomycin I1; Actinomycin IV; Actinomycin X 1; Actinomycin-[thr-val-pro-sar-meval]; Animal Welfare; Assay; Bibliography; Bioassay; Biologic Assays; Biological Assay; CHIP assay; Cancers; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Cognitive; Cosmegen; Country; DACT; DNA Methylation; DNA Polymerase II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II; Dactinomycin; Dactinomycine; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Defect; ES cell; Ecological impact; Elements; Environment; Environmental Impact; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Equipment; Ethics Committees, Research; Fibroblasts; Gene Action Regulation; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Gene Products, RNA; Gene Regulation; Gene Regulation Process; Gene Targeting; Gene Transcription; Generalized Growth; Generations; Genes; Genetic Alteration; Genetic Change; Genetic Imprinting; Genetic Transcription; Genetic defect; Genomic Imprinting; Goals; Growth; Growth and Development; Growth and Development function; HD1; HDAC1; HDAC1 gene; HDAC1 protein, human; Half-Life; Half-Lifes; Hereditary; Histone Deacetylase 1; Histone H1; Histone H1(s); Histones; IACUC; IRBs; Impact, Environmental; Inherited; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Isoforms; Light; Link; Literature; Lyonization; Lyovac cosmegen; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Measures; Meractinomycin; Messenger RNA; Mice; Mice, Mutant Strains; Microarray Analysis; Microarray-Based Analysis; Mining; Minings; Molecular; Murine; Mus; Mutant Strains Mice; Mutation; Neonatal; Parental Imprinting; Parents; Pattern; Photoradiation; Pol II; Predisposition; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Isoforms; RNA; RNA Expression; RNA, Messenger; RNA, Non-Polyadenylated; RPD3; RPD3L1; RPD3L1 protein, human; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Ribonucleic Acid; Stability, mRNA; Susceptibility; Targetings, Gene; Tissue Growth; Transcript; Transcription; Transcription, Genetic; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Work; X Chromosome; X Inactivation; X-Chromosome Inactivation; abstracting; chromatin immunoprecipitation; clinical data repository; clinical data warehouse; data repository; embryonic stem cell; erythrocyte histone deacetylase 1, human; experiment; experimental research; experimental study; expiration; gene expression signature; genome mutation; human HDAC1 protein; human subject; imprint; inhibitor; inhibitor/antagonist; insight; mRNA; mRNA Stability; malignancy; microarray technology; mouse mutant; neoplasm/cancer; null mutation; ontogeny; programs; relational database; research study; stem cell of embryonic origin; transcriptome; vertebrata",Locus-Specific Imprinting on the Mammalian X Chromosome,,57607,MGB,Molecular Genetics B Study Section,,3,331341,
7761696,R01,NS,5,,02/01/2010,01/31/2011,PA-07-140,5R01NS057628-03,,NINDS:378088;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PSYCHIATRY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"CAMPBELL, SCOTT ;",1868260;,5R01NS057628,03/01/2008,01/31/2012,"Accidents; Acute; Age; Architecture; Attention; Awareness; Awarenesses; Behavior; Chronic; Circadian Rhythms; Cognitive; Complex; Control Groups; Decision Making; Delta Wave; Delta Wave sleep; Detection; Development; Diurnal Rhythm; Engineering / Architecture; Fatigue; Financial cost; Hand; Health; Hour; Human; Human, General; Impairment; Injury; Investigators; Knowledge; Laboratories; Lack of Energy; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical; Memory; Modality; Nyctohemeral Rhythm; Paradoxical Sleep; Perception; Performance; Phase; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychomotor Performance; Public Policy; REM Sleep; Randomized; Reaction Time; Recovery; Recovery of Function; Regulation; Relative; Relative (related person); Research; Research Personnel; Researchers; Response RT; Response Time; Rhombencephalic Sleep; Risk; Role; Safety; Sleep; Sleep Architecture; Sleep Deprivation; Sleep, Fast-Wave; Sleep, REM; Slow-Wave Sleep; Societies; Stimulus; System; System, LOINC Axis 4; Testing; Time; Transportation; Twenty-Four Hour Rhythm; Wakefulness; Wakefulnesses; Woman; Work; alertness; circadian; circadian process; cost; daily biorhythm; diurnal variation; dreaming sleep; economic impact; functional recovery; interest; men; men's; neurobehavioral; performance tests; programs; psychomotor function; psychomotor reaction time; randomisation; randomization; randomly assigned; rapid eye movement sleep; response; social role; vigilance",RECOVERY OF SLEEP AND NEUROBEHAVIORAL FUNCTION AFTER SLEEP LOSS,,57628,BRS,Biological Rhythms and Sleep Study Section,,3,378088,
7761694,R01,NS,5,,02/01/2010,01/31/2011,,5R01NS057637-04,,NINDS:161017;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,TUCSON,UNITED STATES,NONE,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"LEVINE, RICHARD B;",1875260;,5R01NS057637,02/01/2007,01/31/2011,"21+ years old; Adult; Animal Model; Animal Models and Related Studies; Apoplexy; Automobile Driving; Axon; Biological Metamorphosis; Biological Models; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Cells; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Coagulation Factor IV; Complex; Culturing, in vitro Vertebrate, Primary; Dendrites; Development; Developmental Process; Disease; Disorder; Drivings, Automobile; Drosophila; Drosophila genus; Drosophila melanogaster; Encephalon; Encephalons; Ensure; Epilepsy; Epileptic Seizures; Epileptics; Factor IV; Fruit Fly, Drosophila; Gated Ion Channel; Generalized Growth; Growth; Health; Human; Human, Adult; Human, General; In Vitro; Ion Channel; Ion Channels, Calcium; Ion Channels, Potassium; Ionic Channels; K channel; K element; Larva; Life; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measurement; Measures; Membrane Channels; Metamorphosis, Biological; Methods and Techniques; Methods, Other; Model System; Models, Biologic; Molecular; Morphology; Motor Cell; Motor Neurons; Nature; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Pathway interactions; Pattern; Potassium; Potassium Channel; Primary Cell Cultures; Property; Property, LOINC Axis 2; Public Health; Receptors, Calcium Channel Blocker; Regulation; Research; Role; Seizure Disorder; Shapes; Signal Pathway; Source; Staging; Stroke; Structure; Techniques; Testing; Therapeutic Steroid Hormone; Tissue Growth; Transgenic Organisms; V (voltage); VDCC; Vascular Accident, Brain; Voltage-Clamp Technics; Voltage-Clamp Technique; Voltage-Dependent Calcium Channels; adult human (21+); brain attack; calcium indicator; cerebral vascular accident; disease/disorder; driving; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; fruit fly; in vivo; insight; metamorphosis; model organism; motoneuron; neuronal; ontogeny; pathway; public health medicine (field); research study; response; social role; steroid hormone; stroke; transgenic; voltage",Postembryonic development of drosophila motoneurons,,57637,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,4,161017,
7763959,R01,NS,5,,02/01/2010,01/31/2011,PA-07-282,5R01NS057704-03,,NINDS:299073;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,PHYSIOLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"APKARIAN, APKAR VANIA;",1871891;,5R01NS057704,02/01/2008,01/31/2013,"AMPA Receptors; Acute; Acute Pain; Address; Adenoviral Vector; Adenovirus Vector; Affect; Affective; Agonist; Aminoacetic Acid; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anatomic; Anatomical Sciences; Anatomy; Animal Welfare; Animals; Area; Arthritis; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Back Ache; Back Pain; Backache; Behavior; Behavioral; Bibliography; Blotting, Western; Brain; Brain Stem; Brain imaging; Brain region; Brainstem; CRPS; CSIF; CSIF-10; Central Nervous System; Chicago; Chronic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Code; Coding System; Cognitive; Collaborations; Common Rat Strains; Complex Regional Pain Syndromes; Consult; Consultations; Consumption; Core Facility; Corpus Striatum; Corpus striatum structure; Country; Cycloserine; Cytokine Receptors; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Data; Differentiation Factor, B-Cell; Drug Controls; Drugs; ELISA; Ecological impact; Emotional; Encephalon; Encephalons; Environment; Environmental Impact; Enzyme-Linked Immunosorbent Assay; Equipment; Ethics Committees, Research; Exhibits; Extinction; Extinction (Psychology); Family; Fear; Fright; Functional Magnetic Resonance Imaging; Germany; Glutamates; Glycine; Glycine, N-methyl-; HPGF; Hand; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IACUC; IFN-beta 2; IFNB2; IL-1; IL-1 inhibitor, urine; IL-10; IL-1ra; IL-6; IL1; IL1 Receptors; IL1 febrile inhibitor; IL10; IL10A; IL1RN; IL6 Protein; IRBs; Imaging Procedures; Imaging Techniques; Impact, Environmental; Impairment; Inflammatory; Infusion; Infusion procedures; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 10 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-1 Receptor Antagonist; Interleukin-1 Receptors; Interleukin-10; Interleukin-6; International; Intervention; Intervention Strategies; Knowledge; L-Glutamate; Lead; Learning; Long-Term Potentiation; Lymphocyte-Stimulating Hormone; MGI-2; MRI, Functional; Macrophage Cell Factor; Magnetic Resonance; Magnetic Resonance Imaging, Functional; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Medial; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Memory; Memory Deficit; Memory impairment; Messenger RNA; Methylglycine; Modeling; Motivation; Myeloid Differentiation-Inducing Protein; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-Aspartate Receptors; N-Methyl-D-aspartate; N-Methylaspartate; N-Methylglycine; NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptors; Neocortex; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuronal Transmission; Neurons; Neuropathy; Nociception; Oral; Outcome; Outcome Study; Pain; Pain Control; Pain Therapy; Pain management; Painful; Patients; Pattern; Pb element; Perception; Peripheral; Persistent pain; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Physiology; Plasmacytoma Growth Factor; Prefrontal Cortex; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Proteins; R-4-Amino-3-isoxazolidinone; RNA, Messenger; RT-PCR; RTPCR; Rat; Rattus; Receptors, AMPA; Receptors, Cytokine; Receptors, IL-1; Receptors, Interleukin-1; Receptors, N-Methylaspartate; Recruitment Activity; Research; Research Ethics Committees; Research Resources; Resources; Reverse Transcriptase Polymerase Chain Reaction; Rewards; Rodent; Rodent Model; Rodentia; Rodentias; Role; Sarcosine; Science of Anatomy; Scientist; Site; Striate Body; Striatum; Study, Outcome; Synaptic plasticity; T Helper Factor; Task Performances; Technics, Imaging; Technology; Testing; Thalamic structure; Thalamus; Therapeutic Agents; Time; Transmission; Universities; Vertebrate Animals; Vertebrates; Visit; Western Blotting; Western Blottings; Western Immunoblotting; Work; abstracting; adeno vector; adenovector; amygdaloid nuclear complex; anakinra; anatomy; arthritic; base; behavioral extinction; brain visualization; central pain; chronic back pain; chronic neuropathic pain; chronic pain; chronic painful condition; clinical investigation; conditioned fear; cortical pain; cost; cytokine; design; designing; drug detection; drug testing; drug/agent; experiment; experimental research; experimental study; expiration; fMRI; fear conditioning; forgetting; gene product; glycine transporter; heavy metal Pb; heavy metal lead; homotypical cortex; human subject; inflammatory neuropathic pain; inflammatory pain; inhibitor; inhibitor/antagonist; injured; interest; interferon beta 2; interleukin 1 inhibitor, urine; interleukin 1 receptor antagonist protein; interventional strategy; isocortex; lymphocyte activating factor; mRNA; memory process; neopallium; neuronal; neuropathic; neuropathic pain; neurotransmission; new therapeutics; next generation therapeutics; nociceptive; novel; novel therapeutics; pain behavior; painful neuropathy; programs; protein blotting; recruit; research study; reverse transcriptase PCR; social role; somatosensory; spatiotemporal; striatal; thalamic; transmission process; urine-derived IL1 inhibitor; vertebrata",Chronic Pain and Emotional Learning and Memory,,57704,ZRG1,Special Emphasis Panel,,3,299073,
7758259,R01,NS,5,,01/01/2010,12/31/2010,PAR-06-459,5R01NS058576-03,,NINDS:601563;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,BIOMEDICAL ENGINEERING,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"NOLL, DOUGLAS C;",1883795;,5R01NS058576,01/01/2008,12/31/2012,"Absorption; Accessory Sinuses; Address; Air; Alcohols; Amplifiers; Artifacts; Automobile Driving; Biomedical Engineering; Blood; Brain; Brain Part; Brain Stem; Brain region; Brainstem; Cell Communication and Signaling; Cell Signaling; Chemical Class, Alcohol; Clinical; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deposit; Deposition; Detection; Development; Disease; Disorder; Drivings, Automobile; Effectiveness; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hyperactive behavior; Hyperactivity; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Image; Imaging Device; Imaging Tool; Imaging technology; Inferior; Intracellular Communication and Signaling; Investigation; Investigators; Lead; Leg; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Magnetism; Medial; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Michigan; Monitor; Morphologic artifacts; NMR Imaging; NMR Tomography; Nasal Sinuses; Nasal cavity/Paranasal; Nasal cavity/Paranasal sinuses; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nuclear Magnetic Resonance Imaging; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Paranasal Sinuses; Patients; Pattern; Pb element; Performance; Physiologic Imaging; Physiologic pulse; Play; Population; Predisposition; Process; Process of absorption; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Pulse; Research; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Blood; Role; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Sinus; Slice; Software Validation; Software Verification; Source; Speed; Speed (motion); Structure; Susceptibility; System; System, LOINC Axis 4; Systems Integration; Techniques; Technology; Temporal Lobe; Testing; Texas; Time; Universities; V (voltage); Validation of Technology; Zeugmatography; absorption; bioengineering; bioengineering/biomedical engineering; biological signal transduction; brain tissue; cost; design; design and construction; designing; disease/disorder; driving; epilepsia; epileptiform; epileptogenic; fMRI; flexibility; frontal cortex; frontal lobe; frontal sinus; heavy metal Pb; heavy metal lead; imaging; improved; interest; magnetic; magnetic field; multidisciplinary; neurodegenerative illness; neuroimaging; neuropsychiatric; neuropsychiatry; new approaches; new technology; novel; novel approaches; novel strategies; novel strategy; patient population; prevent; preventing; programs; radiofrequency; simulation; social role; technology development; technology validation; temporal cortex; temporal lobe/cortex; voltage",MRI Parallel Excitation for Neuroimaging Applications,,58576,ZRG1,Special Emphasis Panel,,3,601563,
7759193,R01,NS,5,,02/01/2010,01/31/2011,PA-07-282,5R01NS058655-03,,NINDS:321596;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN ANTONIO,UNITED STATES,DENTISTRY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"HARGREAVES, KENNETH M;",1902773;,5R01NS058655,02/01/2008,01/31/2013,"6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-; 8-Methyl-N-Vanillyl-6-Nonenamide; Acute; Acute Pain; Address; Afferent Neurons; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animal Welfare; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Aquadiol; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Au element; Bibliography; Biochemical; Biochemical Genetics; Biological; Biopsy; Body Tissues; Bradykinin; Capsaicin; Causality; Cells; Chronic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Colitis, Mucous; Colon, Irritable; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Country; Coupled; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Dental; Dental Pulp; Development; Diffuse Myofascial Pain Syndrome; Dimenformon; Dinoprostone; Diogyn; Diogynets; Disease; Disorder; ERalpha; Ecological impact; Editorial Comment; Editorial Comment (PT); Environment; Environmental Impact; Epidemiology; Epileptiform Neuralgia; Equipment; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol Receptor alpha; Estradiol-17 beta; Estradiol-17beta; Estraldine; Estrogen Receptor alpha; Estrogen Receptors; Estrogenic Agents; Estrogenic Compounds; Estrogens; Ethics Committees, Research; Etiology; Euler-Gaddum Substance P; Evaluation; Female; Fiber; Fibromyalgia; Fibromyositis-Fibromyalgia Syndrome; Fibrositis; Fostering; Fothergill Disease; Fothergill's neuralgia; Future; Gasser's Ganglion; Gasserian Ganglion; Gene Bank; Genetic; Genetic Determinism; Genetic Polymorphism; Genetic, Biochemical; Genotype; Gold; Headache, Migraine; Human; Human, General; IACUC; IRBs; Impact, Environmental; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Irritable Bowel Syndrome; Knee; MPD syndrome; Mammals, Rats; Man (Taxonomy); Man, Modern; Methods; Migraine; Modeling; Molar tooth; Molar, Third; Musculoskeletal Pain; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Nociception; Nociceptors; Operation; Operative Procedures; Operative Surgical Procedures; Oral Surgical Procedures; Orofacial Pain; Ovocyclin; Ovocylin; PGE2; PGE2 alpha; PGE2alpha; Pain; Pain Disorder; Pain, Orofacial; Pain, Postoperative; Painful; Patients; Peripheral; Pharmacogenetics; Phenotype; Policies; Polymorphism (Genetics); Polymorphism, Genetic; Post-operative Pain; Postherpetic neuralgia; Postoperative Pain; Predisposition; Principal Investigator; Programs (PT); Programs [Publication Type]; Progynon; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Published Comment; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Receptor Protein; Receptor Signaling; Regulation; Reporting; Research; Research Ethics Committees; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Rheumatism, Muscular; Risk; Risk Factors; SP(1-11); Semilunar Ganglion; Sensory Cell Afferent Neuron; Signal Pathway; Specific qualifier value; Specified; Stiefel Brand of Capsaicin; Stimulus; Structure of trigeminal ganglion; Structure of wisdom tooth; Substance P; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; Testing; Therapeutic Estradiol; Therapeutic Estrogen; Therapeutic Studies; Therapy Research; Tic Douloureux; Tissues; Tooth Extraction; Tooth, Wisdom; Translational Research; Translational Research Enterprise; Translational Science; Trifacial Neuralgia; Trigeminal Ganglias; Trigeminal Ganglion; Trigeminal Neuralgia; Trigeminal Pain; Trigeminal System; United States National Institutes of Health; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Woman; Work; abstracting; analgesia; cancer pain; clinical data repository; clinical data warehouse; clinical investigation; data repository; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; expiration; fibromyalgia syndrome; genetic determinant; human subject; human tissue; innovate; innovation; innovative; kallidin 9; kallidin I; male; men; men's; molar (dental); myofascial pain dysfunction syndrome; neurokinin 1; neuronal; nociceptive; oral facial pain; oral surgery; polymorphism; post herpetic neuralgia; programs; pulp; rapid method; rapid technique; receptor; relational database; research study; response; sex; sharing data; spastic colon; surgery; surgical pain; translation research enterprise; trifocal neuralgia; trigeminal; vertebrata; wisdom tooth",ESTROGEN MODULATION OF HUMAN NOCICEPTORS,,58655,SCS,Somatosensory and Chemosensory Systems Study Section,,3,321596,
7765500,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS058904-03,,NINDS:314767;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHAPEL HILL,UNITED STATES,PHARMACOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MCCARTHY, KEN DOUGLAS;",1880197;,5R01NS058904,01/01/2008,12/31/2010,"Address; Animal Welfare; Appearance; Astrocytes; Astrocytus; Astroglia; Bibliography; Biological; Brain; Buffers; Calcium Oscillations; Cell Communication and Signaling; Cell Signaling; Cells; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communicating Junction; Communities; Country; Data; Development; Dinoprostone; Drops; Ecological impact; Editorial Comment; Editorial Comment (PT); Elements; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Gap Junctions; Genetic; Glutamates; Grant; Hand; Hortega cell; IACUC; IRBs; Image; Imaging Procedures; Imaging Techniques; Impact, Environmental; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Intracellular Second Messengers; K element; L-Glutamate; L-Serine; Laboratories; Lead; Link; Literature; Low-resistance Junction; Maintenance; Maintenances; Mammals, Mice; Mediating; Medulla Spinalis; Mice; Microglia; Molecular; Murine; Mus; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Nexus; Nexus Junction; Nociception; PGE2; PGE2 alpha; PGE2alpha; Pain; Painful; Paper; Pb element; Play; Potassium; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandins; Prostanoids; Publications; Published Comment; Publishing; Qualifying; Reagent; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Role; Science of neurophysiology; Scientific Publication; Second Messenger Systems; Second Messengers; Serine; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Synapses; Synaptic; Technics, Imaging; Testing; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Waves, Calcium; Work; abstracting; biological signal transduction; chronic pain; chronic painful condition; cytokine; experiment; experimental research; experimental study; expiration; extracellular; gitter cell; heavy metal Pb; heavy metal lead; human subject; imaging; innovate; innovation; innovative; mesoglia; microglial cell; microgliocyte; nervous system disorder; neurological disease; neuronal; neuronal excitability; neurophysiology; nociceptive; perivascular glial cell; programs; research study; response; second messenger; social role; tool; transcription factor; uptake; vertebrata",Role of Spinal Cord Lamina II Astrocytes in Neurophysiology and Chronic Pain,,58904,SCS,Somatosensory and Chemosensory Systems Study Section,,3,314767,
7752539,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS059034-03,,NINDS:299181;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,PHYSIOLOGY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"WU, JIAN-YOUNG ;",1880207;,5R01NS059034,02/15/2008,01/31/2012,"Animal Welfare; Area; Artifacts; Bibliography; Bicuculline; Bioniche Brand of Carbachol; Body Tissues; Brain; Carbachol; Carbacholine; Carbocholine; Cardiac; Cell Communication and Signaling; Cell Signaling; Coloring Agents; Common Rat Strains; Country; Data; Development; Dyes; Ecological impact; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equipment; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethics Committees, Research; Event; Goals; Heart; IACUC; IRBs; Image; Impact, Environmental; Incidence; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Investigators; Lead; Life; Mammals, Rats; Mammals, Rodents; Mission; Modeling; Morphologic artifacts; Motor Cortex; National Institute of Neurological Disorders and Stroke; Nature; Neocortex; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurophysiology / Electrophysiology; Noise; NutraMax Brand of Carbachol; Pattern; Pattern Formation; Pb element; Phase; Play; Population; Principal Investigator; Programs (PT); Programs [Publication Type]; Rat; Rattus; Reporting; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resolution; Resources; Rodent; Rodentia; Rodentias; Role; Science; Seizure Disorder; Seizures; Sensory; Sensory Process; Sensory Seizures; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Slice; Staining method; Stainings; Stains; Stimulus; System; System, LOINC Axis 4; Testing; Therapeutic; Tissues; V (voltage); Vertebrate Animals; Vertebrates; Vibrissae; Whiskers; Work; abstracting; analytical method; barrel cortex; biological signal transduction; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; heavy metal Pb; heavy metal lead; homotypical cortex; human subject; imaging; imaging modality; improved; in vivo; isocortex; neocortical; neopallium; neuronal; prevent; preventing; programs; research study; response; social role; vertebrata; voltage",Spiral dynamics in the cortex during seizure and sensory evoked activity,,59034,ZRG1,Special Emphasis Panel,,3,299181,
7759225,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS059867-03,,NINDS:334590;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,BIOCHEMISTRY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"DAVIS, GRAEME W;",1953092;,5R01NS059867,02/15/2008,01/31/2012,"Animal Welfare; Bibliography; Body Tissues; CD120b; CNS plasticity; Cachectin; Cachectin-Tumor Necrosis Factor; Cachexia; Cactaceae; Cactus; Cancers; Cell Communication and Signaling; Cell Signaling; Central Nervous System; Country; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Denervation; Development; Disease; Disorder; Dorsal; Drosophila; Drosophila genus; EC 2.7; Ecological impact; Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equipment; Ethics Committees, Research; Fruit Fly, Drosophila; Genes; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Glia; Glial Cells; Glutamate Receptor; IACUC; INFLM; IRAK; IRAK1; IRAK1 gene; IRBs; Immunity; Immunoglobulin Enhancer-Binding Protein; Impact, Environmental; Inflammation; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intracellular Communication and Signaling; Kinases; Kolliker's reticulum; Ligands; Malignant Neoplasms; Malignant Tumor; Mammalia; Mammals; Mammals, General; Manuscripts; Molecular; Muscle; Muscle Tissue; Mutation; Myoneural Junction; NF-kB; NF-kappa B; NF-kappaB; NFKB; NRVS-SYS; Nervous; Nervous System; Nervous System, CNS; Nervous system structure; Neuraxis; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neuromuscular Junction; Neuronal Plasticity; Non-neuronal cell; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; P75TNFR; Peripheral; Phosphotransferases; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Source; System; System, LOINC Axis 4; TBPII; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-R-II; TNF-R75; TNF-alpha; TNFA; TNFBR; TNFR2; TNFR80; TNFRSF1B; TNFRSF1B gene; TNFSF2 protein, human; Tissues; Transcription Factor NF-kB; Transphosphorylases; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Vertebrate Animals; Vertebrates; abstracting; base; biological signal transduction; disease/disorder; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; fruit fly; genome mutation; human TNF protein; human subject; kappa B Enhancer Binding Protein; malignancy; neoplasm/cancer; nerve cement; neural; neural plasticity; neurodegenerative illness; neuromuscular; neuromuscular function; neuroplasticity; nuclear factor kappa beta; pelle; postsynaptic; programs; receptor; receptor density; relating to nervous system; research study; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; vertebrata; wasting",TRANS-SYNAPTIC SIGNALING DURING NEUROMUSCULAR DEVELOPMENT,,59867,ZRG1,Special Emphasis Panel,,3,334590,
7760612,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS059882-03,,NINDS:290844;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,ANATOMY/CELL BIOLOGY,02,002604817,US,PA,19104,DREXEL UNIVERSITY,"CASTRO-ALAMANCOS, MANUEL A;",8388316;,5R01NS059882,02/15/2008,01/31/2013,"AMPA Receptors; Animal Welfare; Animals; Area; Behavior; Behavioral; Bibliography; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Country; Disinhibition; Dose; EAA Antagonists; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Excitatory Amino Acid Antagonists; Frequencies (time pattern); Frequency; Glutamate Antagonists; Glutamate Receptor Antagonists; Goals; Human; Human, General; IACUC; IRBs; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Ion Channels, Potassium; K channel; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mediating; Methods; Motor; Motor Cortex; Motor Manifestations; Myoclonic Jerk; Myoclonus; NMDA receptor antagonist; Na element; Neocortex; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurocyte; Neurons; Potassium Channel; Principal Investigator; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pyramidal Cells; R01 Mechanism; R01 Program; RPG; Receptors, AMPA; Research; Research Ethics Committees; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Rodent; Rodentia; Rodentias; Role; Seizures; Slice; Sodium; Somatosensory Cortex; Subcellular Process; Synapses; Synaptic; Testing; Tremor; V (voltage); Vertebrate Animals; Vertebrates; Work; abstracting; behavioral disinhibition; channel blockers; experiment; experimental research; experimental study; expiration; homotypical cortex; human subject; in vivo; ion channel blocker; isocortex; neocortical; neopallium; neural; neuronal; programs; relating to nervous system; research study; social role; somatosensory; somesthetic sensory cortex; vertebrata; voltage",Excitatory Network Oscillations in Somatosensory and Motor Areas of Neocortex,,59882,ZRG1,Special Emphasis Panel,,3,290844,
7760909,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS059893-03,,NINDS:768904;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"ROWITCH, DAVID H;",1866016;,5R01NS059893,02/01/2008,01/31/2013,"Acute; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animal Welfare; Antibodies; Astrocytes; Astrocytus; Astroglia; Bibliography; Brain; Budgets; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Central Nervous System; Chimp; Chimpanzee; Country; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Documentation; Ecological impact; Encephalon; Encephalons; England; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Expression Profiling; Expression Signature; Face; Fibrous Astrocyte; GFP; Gene Expression Profile; Generations; Genetic; Genetic Markers; Glia; Glial Cells; Goals; Green Fluorescent Proteins; Harvest; Heterogeneity; Human; Human, General; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Kolliker's reticulum; Location; London; MS (Multiple Sclerosis); Man (Taxonomy); Man, Modern; Maps; Medulla Spinalis; Mice, Transgenic; Molecular Fingerprinting; Molecular Profiling; Multiple Sclerosis; Nerve Cells; Nerve Unit; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neural Stem Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Non-neuronal cell; Pan; Pan Genus; Pan Species; Primary Senile Degenerative Dementia; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Protoplasmic Astrocyte; Recommendation; Research; Research Ethics Committees; Research Resources; Resources; Role; Sclerosis, Disseminated; Seizures; Spinal Cord; Staging; Testing; Transgenic Mice; Vertebrate Animals; Vertebrates; Work; abstracting; brain cell; cell sorting; cell type; dementia of the Alzheimer type; disease/disorder; expiration; facial; gene expression signature; gray matter; human disease; human subject; insular sclerosis; molecuar profile; molecular signature; nerve cement; nerve stem cell; neural progenitor cells; neuronal; neuronal progenitor; neuronal progenitor cells; primary degenerative dementia; programs; response; senile dementia of the Alzheimer type; social role; substantia alba; substantia grisea; transcription factor; transcriptome; vertebrata; white matter",Cellular and Genetic Origins of Astrocytes,,59893,CMBG,Cellular and Molecular Biology of Glia Study Section,,3,768904,
7752534,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS059934-03,,NINDS:334630;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHICAGO,UNITED STATES,NEUROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"CHETKOVICH, DANE M;",1931679;,5R01NS059934,02/01/2008,01/31/2013,"ATP-protein phosphotransferase; Address; Ammon Horn; Animal Care Assistants; Animal Care Technicians; Animal Technicians; Animal Welfare; Animals; Attenuated; Autoregulation; Bibliography; Binding Proteins; Biochemical; Biochemistry; Biological; CNG channel (rod); CaM KII; CaM PK II; CaM kinase II; CaMKII; Cell Body; Cells; Chemistry, Biological; Chronic; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Cornu Ammonis; Country; Coupled; Critiques; Data; Dendrites; Development; Distal; EEG; Ecological impact; Editorial Comment; Editorial Comment (PT); Electrodes; Electroencephalography; Electrophysiology; Electrophysiology (science); Entorhinal Area; Entorhinal Cortex; Environment; Environmental Impact; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Epileptogenesis; Equipment; Ethics Committees, Research; Evaluation; Exhibits; Figs; Figs - dietary; Goals; Hippocampus; Hippocampus (Brain); Homeostasis; IACUC; IRBs; Impact, Environmental; Implant; Institution; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Left; Life; Ligand Binding Protein; Logistics; Mammals, Rats; Mediating; Membrane Potentials; Methods and Techniques; Methods, Other; Modeling; Monitor; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Neurophysiology / Electrophysiology; Neurosciences; Patients; Phosphorylation; Physiologic; Physiological; Physiological Homeostasis; Physiology; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Protein Kinase; Protein Kinase Inhibitors; Protein Phosphorylation; Published Comment; Pyramidal neuron; Rat; Rattus; Reading; Receptor Activation; Receptors, N-Methylaspartate; Refractory; Research; Research Ethics Committees; Research Resources; Resources; Resting Potentials; Role; Seizure Disorder; Seizures; Slice; Status Epilepticus; Status Epilepticus, Generalized; Structure of entorhinal cortex; Surface; Techniques; Temporal Lobe Epilepsy; Texas; Time; Transmembrane Potentials; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vertebrate Animals; Vertebrates; Veterinary Assistants; Veterinary Nurses; Veterinary Technicians; Viewpoint; Viewpoint (PT); abstracting; austin; calcium-dependent CaM kinase II; calmodulin-dependent protein kinase II; cationic channel protein (rod); cell body (neuron); cyclic-nucleotide gated channel; cyclic-nucleotide gated ion channels; entorhinal cortex; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; glycogen synthase a kinase; hippocampal; hippocampal pyramidal neuron; human subject; hydroxyalkyl protein kinase; improved; neural cell body; neuronal cell body; neuronal excitability; novel; phosphorylase b kinase kinase; prevent; preventing; programs; protein kinase inhibitor; research study; response; social role; soma; trafficking; vertebrata",HCN Channel Trafficking in Epilepsy,,59934,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,3,334630,
7760963,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS060005-02,,NINDS:322211;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,PHYSICAL MEDICINE & REHAB,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"KLINE, ANTHONY E;",1952941;,5R01NS060005,02/01/2009,01/31/2014,"5-HT(1A) Receptor; 5-HT1A Receptor; 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-; Acetyl-CoA[{..}]choline O-acetyltransferase; Acetylcholinesterase Inhibitors; Active Follow-up; Address; Affect; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Animals; Attenuated; Auditory Cortex; Auditory area; Axon; B-50 Protein; Behavioral; Blotting, Western; Buspirone; Care, Health; Caring; Cells; Chemotherapy-Hormones/Steroids; Choline Acetylase; Choline Acetyltransferase; Choline O-Acetyltransferase; Chronic; Clinical; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Combined Modality Therapy; Common Rat Strains; Complex; Cornu Ammonis; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Denervation; Dentate Fascia; Dentate Gyrus; Disturbance in cognition; Drug Therapy; Drugs; Endocrine Gland Secretion; Environment; Estrogenic Agents; Estrogenic Compounds; Estrogens; FDA approved; Fascia Dentata; Female; Figs; Figs - dietary; GAP-43; GAP-43 Protein; GAP43 Protein; Goals; Growth Associated Protein 43; Gyrus Dentatus; Healthcare; Hilar; Hippocampus; Hippocampus (Brain); Home; Home environment; Hormonal; Hormones; Housing; Human; Human, General; Impaired cognition; Individual; Infusion; Infusion procedures; Inhibitors, Acetylcholinesterase; Injection of therapeutic agent; Injections; Injury; Insurance; Intervention; Intervention Strategies; Laboratories; Learning; Left; Lesion; Liquid substance; Living Standards; Maintenance; Maintenances; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measurement; Measures; Medial; Mediating; Mediation; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Memory; Modeling; Motor; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide; Negotiating; Negotiation; Nerve Cells; Nerve Growth Cone Membrane Protein GAP-43; Nerve Unit; Neural Cell; Neurocyte; Neuromodulin; Neurons; Nucleus Basalis Magnocellularis; Optics; Outcome; P38 Membrane Protein, Synaptic Vesicle; Patients; Patients with traumatic brain injury; Percussion; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phosphoprotein B-50; Phosphoprotein F1; Phosphoprotein pp46; Phosphoproteins; Physical Health Services / Rehabilitation; Play; Primary Senile Degenerative Dementia; Process; Protein P38, Synaptic Vesicle; Protocols, Treatment; RGM; Rat; Rattus; Receptor, 5-Hydroxytryptamine 1A; Receptor, Serotonin, 5-HT1A; Recovery; Recovery of Function; Regimen; Rehabilitation; Rehabilitation Centers; Rehabilitation therapy; Rehabilitation, Medical; Reporting; Rodent; Rodentia; Rodentias; Role; Serotonin 1A Receptor; Sex Characteristics; Sex Differences; Staining method; Stainings; Stains; Structure of dentate gyrus; Synapses; Synapsin I; Synaptic; Synaptic plasticity; Synaptophysin; System; System, LOINC Axis 4; TBI Patients; Testing; Therapeutic Estrogen; Therapeutic Hormone; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Treatment Protocols; Treatment Regimen; Treatment Schedule; VAChT protein; Visual; Western Blotting; Western Blottings; Western Immunoblotting; acetylcholine transporter; acetylcholineesterase inhibition; acetylcholineesterase inhibitor; analog; basal forebrain cholinergic neurons; base; behavior test; behavioral test; cholinergic; cholinergic neuron; clinical relevance; clinically relevant; cognitive dysfunction; cognitive loss; cognitive recovery; cognitively impaired; combination therapy; combined modality treatment; combined treatment; controlled cortical impact; dementia of the Alzheimer type; density; dentate gyrus; disability; donepezil; drug/agent; environmental enrichment for laboratory animals; experience; fluid; fluoro jade; follow-up; frontal cortex; frontal lobe; function improvement; functional improvement; functional outcomes; functional recovery; gender difference; hippocampal; improved; intervention development; interventional strategy; liquid; male; morris water maze; morris watermaze; multimodality therapy; neural growth associated protein; neuronal; neuropathology; neurotransmitter release; novel; primary degenerative dementia; protein blotting; public health relevance; rehabilitative; senile dementia of the Alzheimer type; sexual dimorphism (noncellular); social; social role; therapy development; traumatic brain damage; treatment development; treatment strategy; vesicular acetylcholine transporter",Environmental Enrichment and Cholinergic Mechanisms after TBI," Project Narrative Traumatic brain injury is a significant health care issue affecting millions of individuals each year in the US alone. Patients are often left with long lasting physical and cognitive disabilities for which there are no accepted treatments. Pharmacotherapies affecting the cholinergic system have been shown to provide some benefit, as has environmental enrichment. The studies in this proposal seek to evaluate the effects of donepezil and enrichment and their effect on functional outcome after TBI. The study further seeks to test the hypothesis that cholinergic neurons are important mediators of behaviorally induced change after TBI and that there are sex differences in this mediation. The outcome has the potential to provide a novel treatment strategy for rehabilitation of TBI patients.",60005,CND,Clinical Neuroscience and Disease Study Section,,2,322211,
7760193,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS060135-03,,NINDS:358412;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,NEUROSCIENCES,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MCCORMICK, DAVID A;",1901913;,5R01NS060135,02/15/2008,01/31/2012,"3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester; Action Potentials; Adalat; Animal Welfare; Animals; Axon; Axon Terminals; Bibliography; Blood Coagulation Factor IV; Brain; Ca++ element; Calcium; Cell Body; Cells; Cerebral cortex; Coagulation Factor IV; Code; Coding System; Communication; Compensation; Country; Data; Disease; Disorder; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equipment; Ethics Committees, Research; Factor IV; Financial compensation; IACUC; IRBs; Image; Impact, Environmental; In Vitro; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Ion Channel; Ion Channels, Potassium; Ionic Channels; K channel; Knock-out; Knockout; Literature; MS (Multiple Sclerosis); Mammals, Mice; Mediating; Membrane Channels; Membrane Potentials; Mice; Multiple Sclerosis; Murine; Mus; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Neocortex; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nifedipine; Parents; Pattern; Physiologic pulse; Potassium Channel; Potentials, Synaptic; Presynaptic Terminals; Principal Investigator; Procardia; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Pulse; Pyramidal Cells; Receptor Protein; Receptors, N-Methylaspartate; Research; Research Ethics Committees; Research Resources; Resources; Rest; Resting Potentials; Route; Ryanodine; Ryanodol, 3-(1H-pyrrole-2-carboxylate); Sclerosis, Disseminated; Seizure Disorder; Slice; Source; Specificity; Synapses; Synaptic; Synaptic Boutons; Synaptic Potentials; Synaptic Terminals; Testing; Thapsigargin; Time; Toxin; Transmembrane Potentials; Travel; V (voltage); Vertebrate Animals; Vertebrates; Whole-Cell Recordings; abstracting; analog; cell body (neuron); channel blockers; d-APV; digital; disease/disorder; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; expiration; homotypical cortex; human subject; imaging; insular sclerosis; interest; isocortex; neopallium; neural cell body; neuronal; neuronal cell body; patch clamp; presynaptic; programs; receptor; research study; response; soma; tool; two-photon; vertebrata; voltage; voltage clamp",Properties of Axons and Synaptic Communication in the Neocortex,,60135,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,3,358412,
7763869,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS060672-02,,NINDS:328093;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PITTSBURGH,UNITED STATES,NEUROSURGERY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"DIXON, C EDWARD;",6205600;,5R01NS060672,02/15/2009,01/31/2014,"1-Aminoadamantane; 3'5'-cyclic ester of AMP; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Accounting; Adamantylamine; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Age; Amantadine; Attenuated; Behavioral; Behavioral Mechanisms; Binding; Binding (Molecular Function); Biochemical Pathway; CREB; CREB1; CREB1 gene; Calcineurin; Calcineurin antagonist; Calcineurin inhibitor; Cancers; Cardiovascular Diseases; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chronic; Clinical; Clinical Research; Clinical Study; Cognitive; Cognitive deficits; Corpus Striatum; Corpus striatum structure; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Death; Dephosphorylation; Developed Countries; Developed Nations; Development; Disease; Disorder; Dopamine; Dopamine Agonists; Dopamine Receptor Agonists; Dopaminergic Agonists; Drug Therapy; Dysfunction; ERK 1; ERK1 Kinase; Emotional; Enhancers; Experimental Models; Experimental Models, Other; Extracellular Signal-Regulated Kinase 1; FK 506; FK506; Figs; Figs - dietary; Functional disorder; Goals; Human; Human, General; Hydroxytyramine; Individual; Industrialized Countries; Industrialized Nations; Injury; Intracellular Communication and Signaling; Investigators; Job Environment; Job Location; Job Place; Job Setting; Job Site; Knock-out; Knockout; Knockout Mice; L-Threonine; Laboratories; Learning; Life; Limbic System; Location; MAP Kinase 3; MAPK3 Mitogen-Activated Protein Kinase; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Mechanisms of Behavior and Behavior Change; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Meiosis-Activated Myelin Basic Protein Kinase p44(mpk); Memory; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Metabolic Networks; Mice, Knock-out; Mice, Knockout; Microtubule-Associated Protein-2 Kinase; Mitogen-Activated Protein Kinase 3; Modeling; Models, Experimental; Molecular Interaction; Motor; NIPP-1; NIPP1 protein; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Neural Cell; Neurochemistry; Neurocyte; Neuronal Transmission; Neurons; Neurotransmitters; Null Mouse; Outcome; P44MAPK; PDE; PKA; PP2B; PSTkinase p44mpk; Pathway interactions; Performance; Pharmacotherapy; Phase; Phosphatases; Phosphodiesterases; Phosphohydrolases; Phosphomonoesterases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphorylation Site; Physical Health Services / Rehabilitation; Physiopathology; Procedures; Property; Property, LOINC Axis 2; Protein Dephosphorylation; Protein Kinase A; Protein Phosphatase-2B; Protein Phosphorylation; Protein-Serine-Threonine Kinase p44(mpk); Proteins; Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-; Recovery of Function; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research Personnel; Researchers; Residual; Residual state; Response Elements; Role; Rolipram; Science of neurochemistry; Short-Term Memory; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Site; Staging; Striate Body; Striatum; Survivors; System; System, LOINC Axis 4; Testing; Threonine; Threonine Phosphorylation Site; Time; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Tricyclo(3.3.1.13,7)decan-1-amine; United States; Work Location; Work Place; Work-Site; Workplace; Worksite; adenosine 3'5' monophosphate; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cardiovascular disorder; clinical relevance; clinically relevant; cognitive function; cognitive recovery; disability; disease/disorder; dopamine system; experiment; experimental research; experimental study; extracellular; frontal cortex; frontal lobe; functional recovery; gene product; inhibitor; inhibitor/antagonist; injured; injury response; interest; knockout gene; malignancy; mouse model; neoplasm/cancer; neurochemistry; neuronal; neuronal survival; neurotransmission; novel; nuclear inhibitory polypeptide of protein phosphatase-1; p44 (MAPK); p44 MAPK; pathophysiology; pathway; phosphatase inhibitor 1; phosphoric diester hydrolase; pre-clinical; preclinical; protein phosphatase inhibitor-1; public health relevance; rehabilitative; research study; response to injury; social role; striatal; therapeutic target; traumatic brain damage; work environment; work setting; working memory",Dopamine Signaling Mechanisms of Traumatic Brain Injury," PROJECT NARRATIVE In the United States traumatic brain injury (TBI) accounts for over one third of all injury related deaths. In survivors, TBI results in the persistent disturbance of cognitive functioning. This project seeks to examine key neurochemical mechanisms underlying cognitive deficits and to evaluate novel therapies to maximize recovery of function.",60672,ANIE,Acute Neural Injury and Epilepsy Study Section,,2,328093,
7758704,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS060680-02,,NINDS:335673;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"YE, KEQIANG ;",7115022;,5R01NS060680,01/15/2009,12/31/2013,"ARMET Protein; ARMET protein, human; ARP protein, human; ATP-protein phosphotransferase; Acinus organ component; Affect; Alternate Splicing; Alternative Splicing; Apopain; Apoptosis; Apoptosis Pathway; Apoptotic; Arg-rich protein, human; Arginine; Arginine, L-Isomer; Arginine-Rich Mutated in Early Stage Tumors; Arginine-Rich Protein; Back; Binding; Binding (Molecular Function); Biological; Biological Function; Biological Process; C-terminal; CASP-3; CASP3; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death, Programmed; Cell Function; Cell Nucleus; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; Cell-Death Protease; Cellular Function; Cellular Physiology; Cellular Process; Chromatin; Cleaved cell; Common Rat Strains; Cysteine Protease CPP32; DNA Fragmentation; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dorsum; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EC 2.7; Enzymes; Feeds; Goals; Hand; Histones; ICE-like protease; Intracellular Communication and Signaling; Kinases; Knowledge; L-Arginine; L-Serine; Mammals, Rats; Mediating; Molecular; Molecular Interaction; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Nuclear; Nucleus; PARP Cleavage Protease; Patients; Phosphorylation; Phosphotransferases; Physical condensation; Physiologic; Physiological; Play; Process; Protein Kinase; Protein Phosphorylation; Proteins; Putative RNA-Binding Region; Pyramidal neuron; RBD; RNA Binding Domain; RNA Metabolism[{..}] Processing and Transport; RNA Processing; RNA Recognition Motif; RNA Splicing, Alternative; RNP Domain; RNP Motif; RNP-1 Signature; RRM; Rat; Rattus; Regulation; Research; Resistance; Role; SCA-1; SREBP Cleavage Activity 1; Serine; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Stimulus; Subcellular Process; Testing; Transphosphorylases; Two-Hybrid Assay; Two-Hybrid Method; Two-Hybrid System Technics; Two-Hybrid System Techniques; Yama; Yama protein; Yeasts; acinus; arginine-rich protein, human; arginine-rich, mutated in early stage tumors protein, human; biological signal transduction; caspase; caspase-3; cleaved; condensation; cystein protease; cystein proteinase; cysteine endopeptidase; cysteine protease P32; excitotoxicity; experiment; experimental research; experimental study; feeding; gene product; glycogen synthase a kinase; hippocampal pyramidal neuron; human ARMET protein; hydroxyalkyl protein kinase; insight; neurodegenerative illness; neuronal; neuronal survival; novel; phosphorylase b kinase kinase; prevent; preventing; protein kinase C-delta; public health relevance; research study; resistant; social role; upstream kinase",Phosphorylation of Acinus Regulates its Biological Functions," Phosphorylation of Acinus Regulates its Biological Functions Project Narrative Acinus localizes in the specific nuclear compartment, called nuclear speckles, mediating cell survival and RNA processing. Acinus induces chromatin condensation after its cleavage by caspases, which are the enzymes responsible for cutting many cellular proteins. We found that protein kinase Akt, a critical kinase for cell survival and many other cellular functions, phosphorylates acinus, prevents its degradation by caspases, and suppresses chromatin condensation, a process associated with programmed cell death. In our preliminary studies, we also found that protein kinases including PKC-¨ and SRPK2 phosphorylate acinus and modulate its degradation, a process activating acinus. However, whether the phosphorylation by PKC-¨ and SRPK2 plays any role in regulating acinus proteolytic degradation in neurons remains unknown. Further, how these upstream kinases communicate with each other to orchestrate the signaling is unclear. Here, we propose experiments to test the hypothesis that acinus is a physiological substrate of PKC-¨ and SRPK2, and the coordinate phosphorylation by these kinases will delicately define the physiological roles of acinus in neurons. To characterize signaling pathways mediating acinus phosphorylation, proteolytic degradation and programmed cell death activity is essential for understanding not only the physiological functions of acinus, but also the upstream crosstalk dictating the nuclear apoptotic machinery in neurons. This will pave the way for the identification of novel drug targets for the treatment of patients with neurodegenerative diseases.",60680,NOMD,Neural Oxidative Metabolism and Death Study Section,,2,335673,
7770781,R01,NS,5,,02/01/2010,01/31/2011,PAR-06-459,5R01NS060762-03,,NINDS:565774;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,ENGINEERING (ALL TYPES),15,049179401,US,NY,100277003,COLUMBIA UNIV NEW YORK MORNINGSIDE,"JU, JINGYUE ;",8077348;,5R01NS060762,02/01/2008,01/31/2012,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Afferent Neurons; Animal Model; Animal Models and Related Studies; Aplysia; Axon; Axon Terminals; Bio-Informatics; Bioinformatics; Biological; Biology; Biomedical Engineering; Biomedical Research; Brain; CNS plasticity; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cells; Chemistry; Color; DNA Sequence; Development and Research; Distant; Encephalon; Encephalons; Engineering; Engineerings; Enteramine; Eukaryote; Eukaryotic Cell; Event; Experimental Models; Experimental Models, Other; Foundations; Functional Imaging; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profile; Gene Expression Profiling; Gene Products, RNA; Generalized Growth; Genes; Genes, Regulator; Genetics, in situ Hybridization; Genomics; Goals; Growth; Hippophaine; Image; In Situ Hybridization; Intracellular Communication and Signaling; Lead; Learning; Life; Longitudinal Studies; Memory; Messenger RNA; Models, Experimental; Modification; Molecular; Molecular Probes; Monitor; Motor Cell; Motor Neurons; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neural Transmission; Neurites; Neurobiology; Neurocyte; Neurologic Disorders; Neurological Disorders; Neuronal Plasticity; Neurons; Neurons, Afferent; Neurons, Sensory; Neurosciences; Pattern; Pb element; Phase; Phenotype; Physiologic; Physiologic Imaging; Physiological; Population; Presynaptic Terminals; Process; Profilings, Gene Expression; R & D; R&D; RNA; RNA, Messenger; RNA, Non-Polyadenylated; Regulator Genes; Research; Resolution; Ribonucleic Acid; Role; Scheme; Science of Chemistry; Sensory; Sensory Cell Afferent Neuron; Serotonin; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Technology; Testing; Time; Tissue Growth; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Transcriptional Regulatory Elements; Variant; Variation; base; bioengineering; bioengineering/biomedical engineering; biological signal transduction; cost; design; designing; digital; eukaryotida; functional genomics; gene expression signature; gene function; heavy metal Pb; heavy metal lead; imaging; in situ Hybridization Staining Method; innovate; innovation; innovative; long-term study; mRNA; model organism; motoneuron; nervous system disorder; neural plasticity; neurobiological; neurological disease; neuronal; neuronal growth; neuroplasticity; new technology; novel; ontogeny; regulatory gene; research and development; single cell analysis; social role; synapse formation; synaptogenesis; tool; trans acting element; transcriptome; transcriptomics",Molecular Engineering Approach to Study Long Term Synaptic Plasticity,,60762,ZRG1,Special Emphasis Panel,,3,565774,
7766995,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS060801-02,,NINDS:318208;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROSURGERY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"SIMARD, J. MARC ;",1861688;,5R01NS060801,02/15/2009,01/31/2014,"Band Shift Mobility Assay; Bandshift Mobility Assay; Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-; Bleeding; Blood Vessels; Blood capillaries; Body Tissues; Bruise; CHIP assay; Capillaries; Capillary; Capillary Endothelial Cell; Capillary, Unspecified; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cells; Cessation of life; ChIP (chromatin immunoprecipitation); Characteristics; Common Rat Strains; Contusions; Cultured Cells; Data; Death; Electrophoretic Mobility Shift Assay; Employee Strikes; Endothelial Cell, Capillary; Endothelial Cells; Endothelium; Exhibits; FLR; Failure (biologic function); Future; Gene Transcription; Genes; Genes, Reporter; Genetic Transcription; Glibenclamide; Glybenclamide; Glyburide; Hand; Hemorrhage; Histopathology; Human; Human, General; INFLM; Immunoglobulin Enhancer-Binding Protein; In Vitro; Inflammation; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Lead; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Medulla Spinalis; Mice; Mice, Knock-out; Mice, Knockout; Micronase; Mobility Shift Assay; Modeling; Molecular; Murine; Mus; Myelopathy, Traumatic; NF-kB; NF-kappa B; NF-kappaB; NFKB; Necrosis; Necrotic; Nerve Cells; Nerve Unit; Nervous System Physiology; Neural Cell; Neurocyte; Neurologic function; Neurological function; Neurons; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Outcome Measure; Oxidative Stress; Pb element; Physiologic; Physiological; Play; Process; Property; Property, LOINC Axis 2; RNA Expression; Rat; Rattus; Regulation; Reporter Genes; Role; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Strikes; Strikes, Employee; Tissues; Transcription; Transcription Activator; Transcription Coactivator; Transcription Factor Coactivator; Transcription Factor NF-kB; Transcription Regulation; Transcription, Genetic; Transcriptional Activator; Transcriptional Activator/Coactivator; Transcriptional Coactivator; Transcriptional Control; Transcriptional Regulation; Transgenic Organisms; base; biological signal transduction; blood loss; capillary; cell type; chromatin immunoprecipitation; experiment; experimental research; experimental study; failure; gel shift assay; heavy metal Pb; heavy metal lead; improved; in vivo; insight; kappa B Enhancer Binding Protein; knockout gene; mouse model; necrocytosis; nervous system function; neurobehavioral; neuronal; novel; nuclear factor kappa beta; patch clamp; public health relevance; research study; response; social role; transgenic; vascular","Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel"," Project Narrative Using rat and mouse models of spinal cord injury, we discovered that pharmacological inhibition as well as gene suppression of SUR1-regulated NC(Ca-ATP) channels cause a striking reduction in progressive secondary hemorrhage and in hemorrhagic necrosis, and are associated with dramatic improvements in short-term neurological function. In this proposal, we will use gene suppression strategies in rat and mouse models of spinal cord injury to determine short and long-term consequences of SUR1 inhibition and to more fully characterize essential molecular principles governing NC(Ca-ATP) channel expression and function in SCI. These studies will form the basis for novel future therapies for spinal cord injury.",60801,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,2,318208,
7761249,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS060822-03,,NINDS:249231;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLLEGE STATION,UNITED STATES,PSYCHOLOGY,17,078592789,US,TX,77845,TEXAS A&M UNIVERSITY SYSTEM,"MEAGHER, MARY W.;",1911532;,5R01NS060822,02/15/2008,01/31/2012,"Acute; Address; Adolescent; Adolescent Youth; Adverse effects; Aggression; Aggressive behavior; Animal Model; Animal Models and Related Studies; Animal Welfare; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Applications Grants; Assay; Attenuated; Autoimmune; Autoimmune Diseases; Autoimmune Process; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Behavior; Behavioral; Bibliography; Bioassay; Biologic Assays; Biological Assay; Bleeding; Blood Serum; Blood Volume; Body Temperature; Brain; CNS autoimmune disease; Caring; Cellular biology; Chronic; Chronic Disease; Chronic Illness; Chronic Phase of Disease; Consult; Country; Critiques; Cytokines, Chemotactic; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Demyelinations; Development; Development and Research; Differentiation Factor, B-Cell; Disease; Disorder; Dose; ELISA; Ecological impact; Encephalomyelitis; Encephalon; Encephalons; Endocrinology; Environment; Environmental Impact; Enzyme-Linked Immunosorbent Assay; Equipment; Ethics Committees, Research; Exposure to; Frequencies (time pattern); Frequency; Funding; Glucocorticoids; Grant Proposals; Grants, Applications; HPGF; Half-Life; Half-Lifes; Hand; Hemorrhage; Hepatocyte-Stimulating Factor; Home; Home environment; Homologous Chemotactic Cytokines; Human; Human, General; Hybridoma Growth Factor; IACUC; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; IRBs; Immune Function, Cellular; Immune Globulins; Immune response; Immunity; Immunoglobulins; Immunoglobulins / Antibodies; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Impact, Environmental; Individual Differences; Infection; Inflammation; Inflammatory; Institutional Animal Care and Use Committee; Institutional Review Boards; Intercrines; Interdisciplinary Research; Interdisciplinary Study; Interleukin 6 (Interferon, Beta 2); Interleukin-6; International; Laboratories; Leg; MGI-2; MS (Multiple Sclerosis); Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Medulla Spinalis; Metabolism and Endocrinology; Methods; Mice; Modeling; Mortality; Mortality Vital Statistics; Motor; Mouse Polioviruses; Mouse Strains; Multidisciplinary Collaboration; Multidisciplinary Research; Multiple Sclerosis; Murine; Mus; Myelin; Myelitis; Myeloencephalitis; Myeloid Differentiation-Inducing Protein; Myelopathy, Inflammatory; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurosciences; Organ; Outcome; Pain; Painful; Pathogenesis; Phase; Plasmacytoma Growth Factor; Polioviruses, Murine; Preparation; Preventive Intervention; Principal Investigator; Procedures; Process; Programs (PT); Programs [Publication Type]; R & D; R&D; Regimen; Research; Research Design; Research Ethics Committees; Research Resources; Resistance; Resources; Role; SCHED; SIS cytokines; Schedule; Sclerosis, Disseminated; Serum; Severities; Site; Spinal Cord; Spinal Cord Inflammation; Sterility; Stress; Study Type; Study, Interdisciplinary; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; TMEV; TXT; Testing; Text; Theiler Murine Encephalomyelitis Virus; Theiler's Virus; Theiler's encephalomyelitis virus; Therapeutic Glucocorticoid; Thymus-Dependent Lymphocytes; Time; Treatment Side Effects; Vertebrate Animals; Vertebrates; Veterinarians; Viral; Viral Diseases; Virus; Virus Diseases; Viruses, General; WHBLOOD; Whole Blood; abstracting; antibody biosynthesis; autoimmune disease of CNS; autoimmune disorder; base; behavior measurement; behavioral measure; behavioral measurement; blood loss; cell biology; central sensitization; chemoattractant cytokine; chemokine; chronic disease/disorder; chronic disorder; cytokine; design; designing; disease/disorder; dosage; experiment; experimental research; experimental study; expiration; host response; human subject; immune function; immunoglobulin biosynthesis; immunoresponse; insular sclerosis; interferon beta 2; juvenile; juvenile human; mRNA Expression; model organism; motor impairment; neurodegenerative illness; neuroinflammation; neutralizing antibody; novel; preconditioning; prevent; preventing; preventional intervention strategy; programs; research and development; research study; resistant; response; restraint; restraint stress; septic; side effect; social; social role; social stress; sterile; stressor; study design; therapy adverse effect; thymus derived lymphocyte; treatment adverse effect; vertebrata; viral infection; virus infection",Impact of social stress-induced cytokines on an animal model of MS,,60822,NNB,"Neuroendocrinology, Neuroimmunology, and Behavior Study Section",,3,249231,
7751287,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS060910-02,,NINDS:347490;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"CRAINICEANU, CIPRIAN M;",8514422;,5R01NS060910,01/01/2009,12/31/2011,"Area; Biological; Blood Glucose; Blood Sugar; Brain; Cardiovascular Diseases; Cell Communication and Signaling; Cell Signaling; Characteristics; Clinical; Cohort Studies; Complex; Concurrent Studies; Data; Data Quality; Data Set; Dataset; Disease; Disorder; Encephalon; Encephalons; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Functional Magnetic Resonance Imaging; General Population; General Public; Health; Heart; Heterogeneity; Individual; Intracellular Communication and Signaling; Knowledge; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Measurement; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Research; Method LOINC Axis 6; Methodology; Methods; Modeling; Models, Statistical; NMR Imaging; NMR Tomography; Nervous System, Brain; Noise; Nuclear Magnetic Resonance Imaging; Outcome; Policies; Population; Probabilistic Models; Process; Public Health; Quality, Data; Research; Research, Medical; Residual; Residual state; Series; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Architecture; Statistical Methods; Statistical Models; Technology; Time; Uncertainty; Variant; Variation; Visit; Zeugmatography; base; biological signal transduction; cardiovascular disorder; design; designing; disease/disorder; doubt; fMRI; method development; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; public health medicine (field); public health relevance; tool; vector",Statistical Methods for Multilevel Multivariate Functional Studies," Project Narrative  The major benefits of these studies to public health will be to increase our knowledge concerning the effects of sleep on health outcomes. Development of methods to better understand the sleep architecture in the gen- eral population will allow further determination of how medical disorders may disturb sleep and whether sleep disruption is related to health-related consequences.  The methodology proposed is very general and will impact many other areas of scientific research. Two examples of scientific data that would directly benefit from the proposed research are Magnetic Resonance Imaging (MRI) of the brain, heart, etc. and daily blood glucose trajectories recorded at multiple visits.",60910,BMRD,Biostatistical Methods and Research Design Study Section,,2,347490,
7751201,R01,NS,5,,01/19/2010,12/31/2010,PA-07-070,5R01NS061014-03,,NINDS:622098;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BURLINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,066811191,US,VT,05405,UNIVERSITY OF VERMONT & ST AGRIC COLLEGE,"TEUSCHER, CORY ;",2456304;,5R01NS061014,01/19/2008,12/31/2012,"1,2-diacylglycerol; 1H-Imidazole-4-ethanamine; 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol; APC; Amino Acids; Animal Welfare; Antigen-Presenting Cells; Atarax; Autoimmune; Autoimmune Process; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Basophilic Histiocyte; Basophils, Tissue; Bibliography; Binetrakin; Blood - brain barrier anatomy; Blood-Brain Barrier; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CNS Diseases; CNS autoimmune disease; CNS disorder; Cell Communication and Signaling; Cell Signaling; Cells, CD4; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Chiro-Inositol; Chronic; Country; DAG; Data; Development; Diacylglycerols; Diglycerides; Distal; Drug usage; EAE; Ecological impact; Encephalomyelitis; Encephalomyelitis, Allergic; Environment; Environmental Impact; Epidemiology; Equipment; Ethics Committees, Research; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Freund's Adjuvant; Freund's Complete Adjuvant; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Genes; H2R; H3 Receptors; HRH2; HRH2 gene; Hemato-Encephalic Barrier; Histamine; Histamine H1 Receptors; Histamine H2 Receptors; Histamine H3 Receptors; Histamine Receptor; Histamine-Sensitizing Factor; Histidine Carboxy-Lyase; Histidine Decarboxylase; Hybrids; Hydroxyzine; IACUC; IAP Pertussis Toxin; IL-4; IL4; IL4 Protein; IRBs; Immune; Immune response; Immunologic Accessory Cells; Immunostimulants, adjuvants, Freund's; Impact, Environmental; Inflammation Mediators; Inflammatory; Inositol; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin-4; Interleukin-4 Precursor; International; Intracellular Communication and Signaling; Islet-Activating Protein; L-Histidine carboxy-lyase; Length; Literature; Lymphocyte Stimulatory Factor 1; Lymphocytosis-Promoting Factor; MAP2K6; MAP2K6 gene; MAPKK6; MCGF-2; MEK6; MHC Receptor; MKK6; MOG glycoprotein; MS (Multiple Sclerosis); Major Histocompatibility Complex Receptor; Mammals, Mice; Marrow Mast Cell; Mast Cell Growth Factor-2; Mediating; Medulla Spinalis; Mesoinositol; Mice; Mice, Transgenic; Moab, Clinical Treatment; Modeling; Modification; Monoclonal Antibodies; Monocytes / Macrophages / APC; Multiple Sclerosis; Murine; Mus; Myeloencephalitis; Names; Nervous System, CNS; Neuraxis; PRKMK6; Pathogenesis; Patients; Peptides; Permeability; Pertussigen; Pertussis Toxin; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Play; Predisposition; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Publishing; RT-PCR; RTPCR; Receptor Protein; Receptor Signaling; Receptors, Antigen, T-Cell; Receptors, H1; Receptors, H2; Receptors, Histamine H1; Receptors, Histamine H3; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Reverse Transcriptase Polymerase Chain Reaction; Risk; Role; SAPKK3; Sclerosis, Disseminated; Severities; Severity of illness; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Spinal Cord; Susceptibility; T memory cell; T-Cell Growth Factor 2; T-Cell Receptor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Testing; Thymus-Dependent Lymphocytes; Time; Transcript; Transgenic Mice; Transgenic Organisms; Vertebrate Animals; Vertebrates; Vistaril; Wild Type Mouse; Work; abstracting; accessory cell; aminoacid; autoimmune disease of CNS; autoimmune encephalomyelitis; biological signal transduction; cytokine; diacylglycerol; diglyceride; disease severity; drug use; expiration; helper T cell; host response; human subject; immunoresponse; improved; insular sclerosis; intraperitoneal; man; man's; mast cell; mastocyte; memory CD4 T cell; memory CD4 T lymphocyte; memory T lymphocyte; myelin oligodendrocyte glycoprotein; oligodendrocyte-myelin glycoprotein; programs; receptor; response; reverse transcriptase PCR; small molecule; social role; thymus derived lymphocyte; transgenic; treatment strategy; triphosphate; tripolyphosphate; vertebrata",Histamine Receptor Signaling in CNS Autoimmune Disease,,61014,ZRG1,Special Emphasis Panel,,3,622098,
7922556,R01,NS,5,,12/01/2009,11/30/2010,PA-07-070,5R01NS061241-03,,NINDS:334446;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SAN FRANCISCO,UNITED STATES,ANATOMY/CELL BIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"JASMIN, LUC ;",1872874;,5R01NS061241,06/01/2008,11/30/2013,"21+ years old; ATP; Adenosine 5'-(tetrahydrogen triphosphate); Adenosine Triphosphate; Adenylpyrophosphate; Adult; Afferent Neurons; American; Animals; Astroprotein; Behavior; Behavioral; Blood Coagulation Factor IV; Ca++ element; Calcium; Calcium-Activated Potassium Channel; Cell Body; Cell Communication; Cell Communication and Signaling; Cell Interaction; Cell Signaling; Cell-to-Cell Interaction; Chronic; Coagulation Factor IV; Code; Coding System; Common Rat Strains; Communicating Junction; Connexin 43; Connexin43; Cranial Nerve V; Cx43; Deoxyguanylate Cyclase; Double-Stranded RNA; Effects, Longterm; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Environment; Enzymes; Esthesia; Exhibits; Face; Factor IV; Fifth Cranial Nerve; GFA-Protein; GFAP; GTP pyrophosphate-lyase (cyclizing); Ganglia, Sensory; Gap Junctions; Gasser's Ganglion; Gasserian Ganglion; Gene Expression; Gene Inactivation; Gene Silencing; Genes; Genetic; Glia; Glial Cells; Glial Fibrillary Acid Protein; Glial Fibrillary Acidic Protein; Glial Intermediate Filament Protein; Glutamates; Guanyl Cyclase; Guanylate Cyclase; Human, Adult; Individual; Injury; Inosinate Cyclase; Intracellular Communication and Signaling; Intractable Pain; Investigators; Ion Channel; Ion Channels, Potassium; Ion Transport; Ionic Channels; K channel; K element; K+ Channels, Ca2+-Activated; K+ Channels, Calcium-Activated; Kolliker's reticulum; L-Glutamate; Life; Location; Long-Term Effects; Low-resistance Junction; Mammals, Rats; Mediating; Medical center; Membrane Channels; Modeling; Mononitrogen Monoxide; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervus Trigeminus; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neuromediator Receptors; Neurons; Neurons, Afferent; Neurons, Sensory; Neuroregulator Receptors; Neurosurgeon; Neurotransmitter Receptor; Neurotransmitters; Nexus; Nexus Junction; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-neuronal cell; P2Y4 receptors; Pain; Pain, Intractable; Painful; Patients; Perception; Peripheral; Persistent pain; Phenotype; Physiologic; Physiological; Play; Population; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Potassium; Potassium Channel; Principal Investigator; Purine Receptors; Purinoceptor; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Double-Stranded; RNAi; Rat; Rattus; Receptors, Neurohumor; Receptors, Purinergic; Refractory Pain; Regulation; Research; Research Institute; Research Personnel; Researchers; Role; Semilunar Ganglion; Sensation; Sensory; Sensory Cell Afferent Neuron; Sensory Ganglia; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Transduction; Signal Transduction Systems; Signaling; Structure of trigeminal ganglion; Symptoms; Testing; Therapeutic Human Experimentation; Therapeutic Research; Time; Trigeminal Ganglias; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal nerve structure; Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; adult human (21+); behavior test; behavioral test; biological signal transduction; cell body (neuron); cell type; chronic pain; chronic painful condition; constriction; dsRNA; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; facial; gangliocyte; ganglion cell; guanylyl cyclase; improved; injured; intervention development; intractable pain syndrome; member; nerve cement; nerve injury; neural cell body; neural injury; neuronal; neuronal cell body; neuronal excitability; neuropathic pain; neurotransmitter release; painful neuropathy; protein expression; public health relevance; purinoceptor P2Y4; purinoceptors P2Y(4); research study; response; social role; soma; surgeon, neuro-; therapy development; treatment development",Satellite Glial Cells,,61241,CMBG,Cellular and Molecular Biology of Glia Study Section,,3,334446,
7748927,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS061255-03,,NINDS:369976;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"WHALEN, MICHAEL J;",6721731;,5R01NS061255,01/15/2008,12/31/2012,"APO-1 Antigen; APO-1 Cell Surface Antigen; Acute; Animal Welfare; Apoptosis Antigen 1; Bibliography; CD95 Antigens; CD95 molecule; Cachectin; Cachectin-Tumor Necrosis Factor; Cell Death; Cell membrane; Cells; Cellular injury; Cessation of life; Country; Cytoplasmic Membrane; Data; Death; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; IACUC; IRBs; Impact, Environmental; In Vitro; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Iodide, Propidium; Label; Mammals, Mice; Mediating; Membrane; Mice; Modeling; Murine; Mus; Names; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Patients with traumatic brain injury; Permeability; Physiologic pulse; Plasma Membrane; Poloxamer; Poloxamers; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Propidium Diiodide; Protocol; Protocols documentation; Pulse; Research; Research Ethics Committees; Research Resources; Resources; TBI Patients; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFRSF6 Receptor; TNFSF2 protein, human; Testing; Therapeutic Agents; Time; Trauma; Trauma, Brain; Traumatic Brain Injury; Traumatic encephalopathy; Tumor Necrosis Factor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Vertebrate Animals; Vertebrates; abstracting; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene)a block copolymer; base; biomarker; brain cell; cell damage; cell injury; controlled cortical impact; copolymer; expiration; fas Antigens; fas Receptors; functional outcomes; human TNF protein; human subject; improved; in vivo; inhibitor; inhibitor/antagonist; injured; membrane structure; mouse model; necrocytosis; neuronal; neuroprotection; plasmalemma; programs; restoration; therapeutic target; traumatic brain damage; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; vertebrata",Plasmalemma permeability: A therapeutic target for traumatic brain injury?,,61255,BINP,Brain Injury and Neurovascular Pathologies Study Section,,3,369976,
7754035,R01,NS,5,,01/01/2010,12/31/2010,NS-07-005,5R01NS061505-03,,NINDS:361179;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"AYATA, CENK ;",8326480;,5R01NS061505,01/15/2008,12/31/2012,"2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; Animal Welfare; Apoplexy; Area; Arts; Auras; Autoradiography; Bibliography; Blood Vessels; Body Tissues; Brain; CADASIL; Ca(v)2.1; Cav2.1; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Cerebral Ischemia; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Circulation; Cerebrovascular Stroke; Cerebrovascular accident; Chronic; Clinical; Country; Cranial Pain; D-arabino-Hexose, 2-deoxy-; DNA Alteration; DNA mutation; Data; Deoxyglucose; Development; Disease; Disease model; Disorder; Dysfunction; Ecological impact; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Estrus; Ethics Committees, Research; Exhibits; Familial Hemiplegic Migraine; Female; Frequencies (time pattern); Frequency; Functional disorder; Gender; Gene Alteration; Gene Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genetically Engineered Mouse; Gonadal Hormones; Gonadal Steroid Hormones; Head Pain; Headache; Headache, Migraine; Hemiplegia; Hormonal; Human; Human, General; Hypoxia; Hypoxic; IACUC; IRBs; Impact, Environmental; Infarction; Injection of therapeutic agent; Injections; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Intermediary Metabolism; International; Ischemia; Knock-in; Knock-in Mouse; Lead; Leao depression; Lesion; Link; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Processes; Metabolism; Mice; Mice, Mutant Strains; Migraine; Modeling; Molecular; Murine; Mus; Mutant Strains Mice; Mutation; Names; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Netherlands; Neural Cell; Neurocyte; Neurologic; Neurological; Neurons; Neurophysiology / Electrophysiology; Oxygen Deficiency; P-Q type VDCC; Patients; Pb element; Phenotype; Physiologic; Physiological; Physiopathology; Point Mutation; Predisposition; Principal Investigator; Programs (PT); Programs [Publication Type]; Progressive Disease; Proteins; Radioautography; Receptor Protein; Research; Research Ethics Committees; Research Resources; Resources; Risk; Secondary to; Sequence Alteration; Sex Characteristics; Sex Differences; Sex Hormones; Sex Steroid Hormones; Spreading Cortical Depression; Stress; Stroke; Susceptibility; Technology; Testing; Tissue Viability; Tissues; Transgenic Organisms; VEGFs; Vascular Accident, Brain; Vascular Endothelial Growth Factors; Vegf; Vertebrate Animals; Vertebrates; Viability, Tissue; abstracting; aged; base; biomarker; brain attack; cerebral blood flow; cerebral circulation; cerebral hypoperfusion; cerebral vascular accident; cerebrocirculation; clinical relevance; clinically relevant; design; designing; disease/disorder; disorder model; estrous; experiment; experimental research; experimental study; expiration; gender difference; gene product; genome mutation; gonadal steroids; heavy metal Pb; heavy metal lead; high risk; human disease; human subject; imaging modality; infarct; male; mouse model; mouse mutant; mutant; neural; neuronal; novel; omega-agatoxin-IVA-sensitive VDCC; optic imaging; optical imaging; pathophysiology; programs; receptor; relating to nervous system; research study; sex; sex steroid; sexual dimorphism (noncellular); stroke; substantia alba; tool; transgenic; treatment strategy; vascular; vertebrata; voltage-dependent calcium channel (P-Q type); white matter; white matter change",Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models,,61505,ZNS1,Special Emphasis Panel,,3,361179,
7767667,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS061808-02,,NINDS:321596;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROSURGERY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"SIMARD, J. MARC ;",1861688;,5R01NS061808,02/15/2009,01/31/2014,"Apopain; Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-; Bleeding; Blood; Blood - brain barrier anatomy; Blood capillaries; Blood-Brain Barrier; Body Tissues; Brain Hypoxia-Ischemia; CASP-3; CASP3; CNS Injury; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Capillaries; Capillary; Capillary Endothelial Cell; Capillary, Unspecified; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Death; Cells; Central Nervous System Injury; Cerebral Artery Spasm; Cerebral Edema; Cerebrovascular Spasm; Cessation of life; Co-Immunoprecipitations; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Common Rat Strains; Coupled; Cysteine Protease CPP32; Death; Disturbance in cognition; Dropsy; Dysfunction; Edema; Endothelial Cell, Capillary; Forecast of outcome; Functional disorder; Genes; Glibenclamide; Glybenclamide; Glyburide; Grant; Hemato-Encephalic Barrier; Hemorrhage; Hydrops; Hypoxia-Ischemia, Brain; INFLM; Impaired cognition; Inflammation; Inflammatory; Injury of central nervous system; Ion Channel; Ionic Channels; Lead; Link; Mammals, Rats; Measures; Membrane Channels; Messenger RNA; Micronase; Modeling; Molecular; Nature; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Outcome; Outcome Study; PARP Cleavage Protease; Pathway interactions; Patients; Pb element; Physiopathology; Play; Production; Prognosis; Proteins; RNA, Messenger; Rat; Rattus; Reticuloendothelial System, Blood; Rodent Model; Role; SAH; SCA-1; SREBP Cleavage Activity 1; Series; Stimulus; Structure of venule; Study, Outcome; Subarachnoid Hemorrhage; Swelling; Time; Tissues; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vascular constriction (function); Vasoconstriction; Vasospasm; Vasospasm, Cerebral; Venules; Work; Yama; Yama protein; base; blood loss; capillary; caspase-3; central nervous system injury; cognitive dysfunction; cognitive loss; cognitively impaired; cysteine protease P32; cytokine; cytotoxic; experiment; experimental research; experimental study; functional outcomes; gene product; heavy metal Pb; heavy metal lead; hypoxia ischemia; improved; in vivo; inhibitor; inhibitor/antagonist; insight; knock-down; mRNA; necrocytosis; neurobehavioral; neuroinflammation; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal loss; novel; novel therapeutic intervention; outcome forecast; patch clamp; pathophysiology; pathway; prevent; preventing; public health relevance; research study; social role; sulfonylurea receptor; venule",Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara," Project Narrative Subarachnoid hemorrhage (SAH) results in edema, neuronal loss and cognitive dysfunction attributable in part to post-SAH hemotoxicity-induced inflammation independent of vasospasm. Using a rodent model of SAH, we discovered that SUR1 and TRPM4, the molecular subunits of the NC(Ca-ATP) channel, are prominently up-regulated post-SAH. In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH.",61808,BINP,Brain Injury and Neurovascular Pathologies Study Section,,2,321596,
7770895,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS061823-03,,NINDS:311919;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,Menands,UNITED STATES,,21,153695478,US,NY,122042719,WADSWORTH CENTER,"CHEN, XIANG YANG ;WOLPAW, JONATHAN RICKEL (contact);",1886584 (contact);1888816;,5R01NS061823,02/01/2008,01/31/2012,"Adaptive Behaviors; Animal Welfare; Behavior; Behaviors, Adaptive; Bibliography; Brain; Common Rat Strains; Complement; Complement Proteins; Complex; Conditioned Reflex; Country; Disease; Disorder; Ecological impact; Encephalon; Encephalons; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Experimental Models; Experimental Models, Other; Goals; H-Reflex; Human; Human, General; IACUC; IRBs; Impact, Environmental; Individual; Injury; Institutional Animal Care and Use Committee; Institutional Review Boards; Instrumental Learning; International; Laboratories; Lead; Learning; Leg; Life; Locomotion; Maintenance; Maintenances; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medulla Spinalis; Methods; Mice; Models, Experimental; Monkeys; Motor; Motor Skills; Murine; Mus; Muscle; Muscle Tissue; Myelopathy, Traumatic; NRVS-SYS; Names; Nervous System; Nervous System, Brain; Nervous system structure; Neurologic Body System; Neurologic Organ System; Operant Conditioning; Operant Conditionings; Pathway interactions; Pattern; Pb element; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Rat; Rattus; Reflex; Reflex action; Research; Research Ethics Committees; Research Resources; Resources; Somatosensory Evoked Potentials; Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Tendon structure; Tendons; Testing; Therapeutic; Training; Trauma; Vertebrate Animals; Vertebrates; Work; abstracting; adaptation behavior; adaptive behavior; analog; base; conditioning; design; designing; disease/disorder; expiration; heavy metal Pb; heavy metal lead; human subject; improved; improved functioning; instrumental conditioning; neural circuit; neural circuitry; novel; pathway; programs; response; skills; spinal pathway; spinal reflex; stretch reflex; vertebrata",Spinal Reflex Conditioning and Locomotion,,61823,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,3,311919,
7760607,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS061971-03,,NINDS:376818;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BAR HARBOR,UNITED STATES,,02,042140483,US,ME,046091500,JACKSON LABORATORY,"FRANKEL, WAYNE N.;",1870461;,5R01NS061971,02/01/2008,01/31/2013,"Alleles; Allelomorphs; Ammon Horn; Animal Model; Animal Models and Related Studies; Animal Welfare; Architecture; Behavioral; Bibliography; Brain; Brain Diseases; Brain Disorders; CNS Diseases; CNS disorder; Cell Communication and Signaling; Cell Signaling; Central Nervous System Diseases; Central Nervous System Disorders; Clinical; Complex; Cornu Ammonis; Country; Development; Disease; Disorder; Dysfunction; Ecological impact; Encephalon; Encephalon Diseases; Encephalons; Engineering / Architecture; Environment; Environmental Impact; Epilepsy; Epileptic Seizures; Epileptics; Equilibrium; Equipment; Ethics Committees, Research; Family; Functional disorder; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Targeting; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Genotype; Goals; Hereditary Disease; Hippocampus; Hippocampus (Brain); Human; Human, General; IACUC; IRBs; Impact, Environmental; Individual; Insertion Mutation; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Ion Channel; Ionic Channels; Knock-out; Knockout; Lead; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane Channels; Membrane Potentials; Mental disorders; Mental health disorders; Messenger RNA; Mice; Mice, Mutant Strains; Mice, Transgenic; Modeling; Molecular Disease; Murine; Mus; Mutant Strains Mice; Mutation; Names; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Neuromediator Receptors; Neuroregulator Receptors; Neurotransmitter Receptor; Pathology; Pb element; Phenotype; Physiologic; Physiological; Physiopathology; Polygenic Characters; Polygenic Inheritances; Polygenic Traits; Principal Investigator; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Proteins; Psychiatric Disease; Psychiatric Disorder; RNA, Messenger; RNA-Binding Proteins; Receptors, Neurohumor; Regulation; Research; Research Ethics Committees; Research Resources; Resources; Resting Potentials; Role; Schizophrenia; Schizophrenic Disorders; Seizure Disorder; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Synapses; Synaptic; System; System, LOINC Axis 4; Targetings, Gene; Transcript; Transcript Expression Analyses; Transcript Expression Analysis; Transgenic Mice; Transgenic Organisms; Transmembrane Potentials; Unspecified Mental Disorder; Variant; Variation; Vertebrate Animals; Vertebrates; Vision; abstracting; balance; balance function; biological signal transduction; combinatorial; complex biological systems; dementia praecox; disease/disorder; epilepsia; epileptiform; epileptogenic; expiration; gene product; genetic disorder; genetic variant; genome mutation; genome sequencing; heavy metal Pb; heavy metal lead; hereditary disorder; hippocampal; human subject; interest; interventional strategy; mRNA; member; mental illness; model organism; mouse mutant; mutant; nervous system disorder; neurological disease; neuronal excitability; non-genetic; pathophysiology; programs; psychological disorder; schizophrenic; social role; success; synapse function; synaptic function; transgenic; vertebrata",Genetic Regulation of Complex Neurological Disease,,61971,GHD,Genetics of Health and Disease Study Section,,3,376818,
7758790,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS062059-02,,NINDS:611552;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"NYQUIST, PAUL ALAN;",8898728;,5R01NS062059,01/15/2009,12/31/2013,"African American; Afro American; Afroamerican; Age; Aged 65 and Over; Apoplexy; Arteries; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BMI percentile; BMI z-score; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basal Ganglia; Basal Nuclei; Biological Function; Biological Models; Biological Process; Black Populations; Black or African American; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood Pressure; Blood Vessels; Body mass index; Brachial Artery; Brain; Brain Vascular Disorders; CCL2; CCL2 gene; Candidate Disease Gene; Candidate Gene; Cardiac; Cardiac artery; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Disease; Cerebrovascular Disorders; Cerebrovascular Stroke; Cerebrovascular accident; Coagulation Factor I; Coagulation Factor One; Cognitive deficits; Communities; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary artery; Coronary heart disease; D-Glucose; Data; Dextrose; Differentiation Factor, B-Cell; Diffuse; Dilatation; Dilatation - action; Disease; Disorder; Dysfunction; Elderly; Elderly, over 65; Encephalon; Encephalons; Endothelium; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epidemiology, Family Medical History; Event; Exercise; Exercise Thallium; Exercise, Physical; Factor I; Factor One; Family; Family Medical History; Family history of; Family member; Fibrinogen; Functional disorder; Future; GDCF-2; GDCF-2 HC11; Gamma Camera Imaging; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Genetic analyses; Genotype; Glucose; HC11; HPGF; Haplotypes; Heart; Heart artery; Hepatocyte-Stimulating Factor; History; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-6; IL6 Protein; INFLM; Image; Individual; Infarction; Inflammation; Inflammatory; Inherited Predisposition; Inherited Susceptibility; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intracranial Vascular Disorders; Lesion; Lipids; Lipoprotein (a); Lipoprotein Lp(a); Lp(a); MCAF; MCP-1; MCP1; MGC9434; MGI-2; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Mediating; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Model System; Modeling; Models, Biologic; Motion; Myeloid Differentiation-Inducing Protein; NMR Imaging; NMR Tomography; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; PAI-1; PAI1; PLANH1; Perfusion; Persons; Physiopathology; Pilot Projects; Plasmacytoma Growth Factor; Plasminogen Activator Inhibitor 1; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Predisposition; Prevalence; Process; Quetelet index; Race; Racial Group; Radionuclide Imaging; Recording of previous events; Risk; Risk Factors; SCYA2; SMC-CF; SNP; SNPs; Sampling; Scanning, Radioisotope; Scintigraphy; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Siblings; Single Nucleotide Polymorphism; Stocks, Racial; Stress; Stress Thallium Test; Stroke; Structure of brachial artery; Study models; Susceptibility; Thalamic structure; Thalamus; Thallium; Thallium Myocardial Perfusion Imaging Stress Test; Thrombosis; Tl element; Trees; Type 1 Plasminogen Activator Inhibitor; Vascular Accident, Brain; Vascular Diseases; Vascular Diseases, Intracranial; Vascular Disorder; Weight; Zeugmatography; advanced age; atheromatosis; atherosclerotic vascular disease; base; biomarker; black American; blood vessel disorder; brachial artery; brain attack; brain volume; cardiovascular risk; cardiovascular risk factor; cerebral vascular accident; cigarette smoking; coronary disorder; design; designing; disease phenotype; disease risk; disease/disorder; disorder risk; elders; family structure; genetic analysis; genetic etiology; genetic mechanism of disease; genetic profiling; genetic variant; genetic vulnerability; geriatric; high risk; imaging; infarct; inflammatory marker; interferon beta 2; late life; later life; mid life; mid-life; middle age; middle aged; midlife; older adult; older person; pathophysiology; pilot study; polymorphism; population based; pre-clinical; preclinical; premature; proband; public health relevance; radionuclide imaging/scanning; radionuclide scanning; respiratory; senior citizen; sex; smoke cigarette; stroke; substantia alba; thalamic; tomography; trait; vascular; vascular endothelial dysfunction; vascular inflammation; white matter",Occult Small Vessel Cerebrovascular Disease in High Risk Families," This study will focus on the occurrence of vascular disease in the heart and brain and is designed to examine new epidemiologic models of atherosclerosis that include mechanisms such as inflammation, thrombosis and vascular function. It is also focused on the genes that may increase the susceptibility to small vessel disease in high risk families with a history of disease.",62059,NAME,"Neurological, Aging and Musculoskeletal Epidemiology Study Section",,2,611552,
7755837,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS062358-02,,NINDS:268538;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"EVAVOLD, BRIAN D.;",1868103;,5R01NS062358,01/15/2009,12/31/2013,"ATGN; Active Sites; Adverse effects; Affect; Affinity; Animal Model; Animal Models and Related Studies; Antigenic Determinants; Antigens; Autoantigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Responses; Autologous Antigens; Axon; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binding; Binding (Molecular Function); Binding Determinants; Binetrakin; Biological; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Therapy; Cells; Cells, CD4; Central Nervous System; Clinical; Clinical Trials; Clinical Trials, Unspecified; Co-Stimulator; Costimulator; Cysteine; Data; Demyelinations; Disease; Disorder; Drug usage; Drugs; EAE; Encephalomyelitis, Allergic; Enzymes; Epidermal Thymocyte Activating Factor; Epitopes; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; FDA approved; Future; Generations; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; HC phosphatase; HCP; HCPH; HPTP1C; Half-Cystine; Hcph gene product; HePTP; Human; Human, General; IFN; IL-2; IL-4; IL2; IL2 Protein; IL4; IL4 Protein; Immune; Immune response; Immune system; Immunomodulation; Immunosuppressants; Immunosuppressive Agents; Inflammatory Response; Interferons; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukin-4; Interleukin-4 Precursor; Interleukine 2; Interleukine 2 Precursor; Interleukine II; L-Cysteine; Lead; Ligands; Lymphocyte Mitogenic Factor; Lymphocyte Stimulatory Factor 1; MCGF-2; MHC Receptor; MS (Multiple Sclerosis); Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Measures; Mediating; Medication; Methods; Mice; Mitogenic Factor; Modeling; Modification; Molecular Interaction; Multiple Sclerosis; Murine; Mus; Mutate; Mutation; Myelin; Myelin Basic Proteins; Nervous System, CNS; Neuraxis; PTP-1C; PTPN6; PTPN6 gene; Pathogenesis; Pathway interactions; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphorylation; Play; Population; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Production; Protein Modification; Protein Modification, Post-Translational; Protein Phosphorylation; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Receptors, Antigen, T-Cell; Recruitment Activity; Regulation; Regulatory T-Lymphocyte; Reporting; Rodent Model; Role; Role of Tob in T-cell activation; SH-PTP1; SHP PTPase; SHP-1; SHP-1 phosphatase; SHP-1 tyrosine phosphatase; SHP-1L; SHP1 gene product, phosphatase; SHP1 phosphatase; SHP1 protein tyrosine phosphatase; SHPTP1; Sclerosis, Disseminated; Self-Antigens; Severities; Sites, Active; Specificity; Symptoms; T cell growth factor; T cell regulation; T-Cell Activation; T-Cell Activation Pathway; T-Cell Growth Factor; T-Cell Growth Factor 2; T-Cell Proliferation; T-Cell Receptor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; Testing; Therapeutic; Therapy, Cell; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Treatment Side Effects; Tyrosine Phosphorylation; Variant; Variation; analog; anergy; autoimmune disorder; autoimmune encephalomyelitis; base; body system, allergic/immunologic; cell-based therapy; clinical investigation; copolymer 1; design; designing; disease/disorder; drug efficacy; drug use; drug/agent; effective therapy; experiment; experimental research; experimental study; genome mutation; glatiramer acetate; haematopoietic cell phosphatase; heavy metal Pb; heavy metal lead; helper T cell; hematopoietic cell-specific tyrosine phosphatase SHP-1; host response; human hematopoietic tyrosine phosphatase; immune modulation; immunogen; immunologic reactivity control; immunoregulation; immunoresponse; immunosuppressive; improved; insular sclerosis; model organism; new approaches; new therapeutics; next generation therapeutics; novel; novel approaches; novel strategies; novel strategy; novel therapeutics; organ system, allergic/immunologic; overexpression; oxidation; pathway; peptide analog; prevent; preventing; prospective; protein-tyrosine phosphatase SHP; public health relevance; recruit; research study; response; side effect; social role; therapy adverse effect; thymus derived lymphocyte; treatment adverse effect; tumor",Negative Regulatory Mechanisms for Myelin Specific T cells," Narrative The overall goal of this grant is to define the mechanisms of T cell anergy induced using variants of myelin antigens as a means for controlling autoimmune disease in the central nervous system. T cells play a major role in the pathogenesis of Multiple Sclerosis and the related animal model EAE, indicating that the control of the autoimmune T cell responses is paramount for any beneficial therapy. As a result, all current treatments for MS attempt to target T cells in some fashion. We describe a model for regulation of the T cell response through the activation of the tyrosine phosphatase SHP-1 by MHC variant peptides, suggesting that both could form the basis for future therapies effective against MS as well as other autoimmune diseases. We propose to test our hypothesis using murine EAE models, but our results should be rapidly transferable to human cells. Therefore, our findings are highly relevant to MS and could provide a future treatment by specifically limiting the autoimmune T cell response.",62358,CNBT,Clinical Neuroimmunology and Brain Tumors Study Section,,2,268538,
7758706,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS062792-02,,NINDS:329137;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ANN ARBOR,UNITED STATES,BIOCHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"XU, HAOXING ;",9229360;,5R01NS062792,01/15/2009,12/31/2013,"0-11 years old; Adenosine 5'-(trihydrogendiphosphate), 2'-(dihydrogen phosphate), 5'-5'-ester with 3-carboxy-1-beta-D-ribofuranosylpyridinium hydroxide, inner salt; Anemia; Appearance; Assay; Autoregulation; Bacteria; Behavior; Bioassay; Biochemistry; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Cations; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell membrane; Cells; Chelating Agents; Chelators; Chemistry, Biological; Child; Child Youth; Children (0-21); Clinical; Complexons; Cytoplasmic Membrane; Data; Deaf; Defect; Degenerative Diseases, Nervous System; Degenerative Disorder; Degenerative Neurologic Disorders; Disease; Disorder; Dysfunction; Electrophysiology; Electrophysiology (science); Endoplasmic Reticulum; Endosomes; Ergastoplasm; Event; Exhibits; Exocytosis; Family; Fe element; Fibroblasts; Functional disorder; Ganglioside Sialidase Deficiency Disease; Garbage; Garbages; Genetic Alteration; Genetic Change; Genetic defect; Goals; Hard of Hearing Persons; Hearing Impaired Persons; Homeostasis; Human; Human, Child; Human, General; Image; Immunochemistry; Intracellular Communication and Signaling; Ion Channel; Ionic Channels; Ions; Iron; Iron Overload; Iron Staining Method; Iron deficiency anemia; Killings; Lipofuscin; Lysosomes; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mediating; Membrane Channels; Mental Retardation; Methods; Mice; Mice, Mutant Strains; Molecular; Monitor; Motor; Mucolipidoses; Mucolipidosis IV; Mucolipidosis Type IV; Murine; Mus; Mutant Strains Mice; Mutation; NAADP; Nerve Degeneration; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurophysiology / Electrophysiology; Outcome; Oxidative Stress; Pathway interactions; Patients; Persons With Hearing Impairments; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Pigmentation; Pigmentation physiologic function; Plasma Membrane; Play; Proteins; Receptor Protein; Receptosomes; Recycling; Research; Retinal; Retinal Degeneration; Role; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Skin; Testing; Therapeutic; bactericidal; bactericide; base; biological signal transduction; children; degenerative condition; degenerative disease; disease/disorder; fluorescence imaging; gene product; genome mutation; imaging; insight; interdisciplinary approach; iron metabolism; late endosome; macrophage; mouse mutant; necrocytosis; neural degeneration; neurodegeneration; neurodegenerative illness; neuronal degeneration; nicotinate adenine dinucleotide phosphate; nicotinic acid adenine dinucleotide phosphate; patch clamp; pathophysiology; pathway; plasmalemma; public health relevance; receptor; retina degeneration; retinal degenerative; social role; youngster",The Mucolipin TRP Ion Channels,,62792,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,2,329137,
7758759,R01,NS,5,,01/01/2010,12/31/2010,PA-07-070,5R01NS062972-02,,NINDS:355163;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,GENETICS,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"MCCALLION, ANDREW S;",7842776;,5R01NS062972,01/15/2009,12/31/2013,"Accounting; Algorithms; Analysis, Data; Assay; Binding Sites; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Body Tissues; Brachydanio rerio; Central Nervous System; Combining Site; Computer Simulation; Computerized Models; Conserved Sequence; DNA Sequence; Danio rerio; Data; Data Analyses; Data Set; Dataset; Development; Disease; Disorder; Dysfunction; Functional RNA; Functional disorder; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genes, Reporter; Goals; Human; Human, General; Idiopathic Parkinson Disease; In Vitro; Instruction; Lewy Body Parkinson Disease; Light; Location; Maintenance; Maintenances; Mammals, Mice; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mental disorders; Mental health disorders; Mice; Models, Computer; Murine; Mus; Mutate; Mutation Detection; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, CNS; Neural Cell; Neural Growth; Neuraxis; Neurocyte; Neuron Degeneration; Neuronal Growth; Neurons; Non-Coding; Non-Coding RNA; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Photoradiation; Physiopathology; Play; Population; Primary Parkinsonism; Psychiatric Disease; Psychiatric Disorder; Publishing; Reactive Site; Reagent; Regulatory Element; RegulatoryElement; Reporter; Reporter Genes; Role; Simulation, Computer based; System; System, LOINC Axis 4; Testing; Time; Tissues; Transcript; Transgenes; Transgenic Organisms; Unspecified Mental Disorder; Vertebrate Animals; Vertebrates; Zebra Danio; Zebra Fish; Zebrafish; base; cell type; computational modeling; computational models; computational simulation; computational tools; computer based models; computerized modeling; computerized simulation; computerized tools; cost; cost effective; disease/disorder; genome sequencing; genome-wide; improved; in silico; in vivo; markov model; mental illness; nervous system development; neural degeneration; neurodegeneration; neurogenesis; neuron development; neuronal; neuronal degeneration; pathophysiology; psychological disorder; public health relevance; repository; social role; transcription factor; transgenic; vertebrata; virtual simulation",Development of a Neuronal Regulatory Lexicon," We wish to better understand how the regulatory instructions of critical developmental and disease genes are encoded in DNA sequence. We will focus on genes important for the neurons that are lost in disorders like Parkinson's disease. We also aim to establish new computational paradigms, and generate reagents, that will have wide applicability to understanding the wealth of information arising out of genome sequencing efforts.",62972,MNG,Molecular Neurogenetics Study Section,,2,355163,
7763779,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS063878-02,,NINDS:367538;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,OMAHA,UNITED STATES,PHARMACOLOGY,02,168559177,US,NE,681987835,UNIVERSITY OF NEBRASKA MEDICAL CENTER,"XIONG, HUANGUI HANK;",6065001;,5R01NS063878,02/01/2009,01/31/2014,"2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol; AIDS; AIDS Virus; AIDS test; AIDS/HIV test; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acquired brain injury; Affect; Amentia; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Antiretroviral Therapy, Highly Active; Apopain; Apoptotic; Arm; Assay; Astrocytosis; Basal Ganglia; Basal Nuclei; Bathing; Baths; Behavior; Bioassay; Biologic Assays; Biological; Biological Assay; Blood; Blood monocyte; Blotting, Western; Body Tissues; Brain; Brain Injuries; Brain region; CASP-3; CASP3; CD154 Antigens; CD40 Ligand; CD40-L; CPP-32; CPP32; CPP32 protein; CPP32B; CPP32beta; Caspase 3, Apoptosis-Related Cysteine Protease; Cell Communication and Signaling; Cell Death; Cell Death Signaling; Cell Death Signaling Process; Cell Signaling; Cell Survival; Cell Viability; Cell model; Cells; Cellular model; Cessation of life; Chronic; Co-culture; Cocultivation; Coculture; Coculture Techniques; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Coloring Agents; Common Rat Strains; Conditioned Culture Media; Conditioned Medium; Control Animal; Cornu Ammonis; Cues; Culture Media, Conditioned; Cysteine Protease CPP32; Cytokines, Chemotactic; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia; Development; Disease; Disorder; Disturbance in cognition; Dyes; Dysfunction; Electrodes; Encephalon; Encephalons; Exhibits; FLR; Face; Failure (biologic function); Figs; Figs - dietary; Foundations; Frequencies (time pattern); Frequency; Functional disorder; Funding; Genes; Giant Cells; Glia; Glial Cells; Glutamates; Goals; HAART; HIGM1; HIV; HIV encephalitis; HIV test; HIV-1; HIV-I; HIV1; HTLV-III; Highly Active Antiretroviral Therapy; Hippocampus; Hippocampus (Brain); Homologous Chemotactic Cytokines; Hortega cell; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human immunodeficiency virus test; Human, General; Hydrogen Oxide; IL-1; IL1; IMD3; Immune; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Impaired cognition; Impairment; Individual; Indoles; Infection; Inflammatory; Intercrines; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; Iodide, Propidium; Knock-out; Knockout; Kolliker's reticulum; L-Glutamate; LAV-HTLV-III; Laboratories; Laboratory Animal Models; Learning; Link; Location; Long-Term Potentiation; Lymphadenopathy-Associated Virus; Lymphocyte-Stimulating Hormone; MAP2 Microtubule-Associated Protein; MK 801; MK801; Macrophage Activation; Macrophage Cell Factor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Memory; Methods and Techniques; Methods, Other; Mice; Microglia; Microtubule-Associated Protein 2; Modeling; Models, Laboratory Animal; Mononuclear; Morphology; Multinucleated Giant Cells; Murine; Mus; N Methyl D aspartic Acid; N methyl D aspartate; N-Methyl-D-aspartate; N-Methylaspartate; NDUL; NMDA; NR1; NR1 gene; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocognitive; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neuronal Dysfunction; Neuronal Injury; Neurons; Neuropathogenesis; Neurotoxins; Nodule; Non-neuronal cell; Oocytes; Ovocytes; PARP Cleavage Protease; Pathogenesis; Pathway interactions; Patients; Perfusion; Phagocytes; Phagocytic Cell; Physiology; Physiopathology; Play; Polykaryocytes; Prevention; Property; Property, LOINC Axis 2; Propidium Diiodide; Proteins; Proteomics; Protocol; Protocols documentation; RNA, Small Interfering; Radial; Rat; Rattus; Receptor Protein; Relative; Relative (related person); Research; Reticuloendothelial System, Blood; Role; SCA-1; SCID; SCID Mice; SIS cytokines; SREBP Cleavage Activity 1; Scheme; Severe Combined Immunodeficient Mice; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Slice; Small Interfering RNA; Staining method; Stainings; Stains; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; Syncytium; System; System, LOINC Axis 4; T Helper Factor; T-B Cell Activating Molecule; TNF-Related Activation Protein; Techniques; Testing; Therapeutic; Time; Tissues; Toxin; Tumor Necrosis Factor Ligand Superfamily Member 5; Upper arm; Viral; Viral Diseases; Virus; Virus Diseases; Virus Replication; Virus-HIV; Viruses, General; Water; Western Blotting; Western Blottings; Western Immunoblotting; Work; Xenopus oocyte; Yama; Yama protein; alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol; amebocyte; anti-retroviral therapy, highly active; aspartate receptor; aspartic acid receptor; base; behavior test; behavioral test; biological signal transduction; biological systems; brain damage; brain lesion (from injury); caspase-3; channel blockers; chemoattractant cytokine; chemokine; cognitive change; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; cysteine protease P32; cytokine; disease/disorder; excitotoxicity; experiment; experimental research; experimental study; facial; failure; gene product; gitter cell; gp39; gp39 Antigen, T-Cell; hippocampal; human T cell leukemia virus III; human T lymphotropic virus III; human disease; ifenprodil; in vivo; insight; knock-down; lymphocyte activating factor; macrophage; memory process; mesoglia; microglial cell; microgliocyte; model organism; monocyte; mouse model; necrocytosis; nerve cement; neural degeneration; neurodegeneration; neurodegenerative illness; neuron injury; neuronal; neuronal degeneration; neuronal survival; neuropathology; neurotoxic; neurotoxicant; neurotropic; pathophysiology; pathway; perivascular glial cell; postsynaptic; prevent; preventing; protective effect; protein blotting; public health relevance; receptor; release factor; research study; response; severe combined immune deficiency; siRNA; social role; therapeutic target; viral infection; virus infection; virus multiplication; voltage clamp","Macrophages, NR2B-containing NMDA Receptors and HIV Dementia"," Narrative: Synaptic N-methyl-D-aspartic acid (NMDA) receptors (NMDARs), composed, in large part, of NR2A-containing NMDARs (NR2ARs), promote cell survival, whereas extrasynaptic NMDARs, NR2B-containing NMDARs (NR2BRs), induce cell death. This proposal investigates how HIV-1-infected mononuclear phagocytes (brain macrophages and microglia) activate neuronal extrasynaptic NR2BRs, leading to neuronal damage and ultimately neurocognitive dysfunction. By completion of the proposed studies we will not only provide new insights into the mechanisms underlying the neuropathogenesis of HIV-1 infection, but also furnish new target(s) for the development of potential therapies in the prevention and treatment of HIV-1 disease.",63878,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,2,367538,
7762833,R01,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R01NS064025-02,,NINDS:314016;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BIRMINGHAM,UNITED STATES,NEUROSCIENCES,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"OVERSTREET-WADICHE, LINDA ;",8972419;,5R01NS064025,02/01/2009,01/31/2014,"0-6 weeks old; 21+ years old; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Action Potentials; Address; Adult; Aminalon; Aminalone; Ammon Horn; Attention; Behavior; Biological Models; Biological Neural Networks; Brain; Butanoic acid, 4-amino-; Cell Communication and Signaling; Cell Death; Cell Signaling; Cell Survival; Cell Viability; Cells; Communities; Connector Neuron; Cornu Ammonis; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dentate Fascia; Dentate Gyrus; Development; Disease; Disorder; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Exercise; Exercise, Physical; Fascia Dentata; GABA; Gene Expression; Genetic Condition; Genetic Diseases; Goals; Gyrus Dentatus; Hereditary Disease; Hippocampus; Hippocampus (Brain); Human, Adult; Image; Infant, Newborn; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intracellular Communication and Signaling; Kinetic; Kinetics; Learning; Link; Literature; Mammals, Mice; Measures; Mediating; Methods; Methods and Techniques; Methods, Other; Mice; Model System; Models, Biologic; Modification; Molecular; Molecular Disease; Murine; Mus; Natural regeneration; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Growth; Neural Stem Cell; Neurochemistry; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuronal Growth; Neurons; Neurophysiology / Electrophysiology; Neurosciences; Newborn Infant; Newborns; Pattern; Regeneration; Regulation; Reporter; Role; Science of neurochemistry; Signal Transduction; Signal Transduction Systems; Signaling; Source; Staging; Stimulus; Stress; Structure of dentate gyrus; Synapses; Synaptic; Techniques; Testing; Transgenic Organisms; Translating; Translatings; V (voltage); adult human (21+); adult neurogenesis; base; biological signal transduction; critical period; dentate gyrus; disease/disorder; environmental enrichment for laboratory animals; experience; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; genetic disorder; granule cell; hereditary disorder; hippocampal; imaging; improved; in vitro Model; insight; language translation; necrocytosis; nerve stem cell; neural; neural circuit; neural circuitry; neural network; neural progenitor cells; neurochemistry; neurodegenerative illness; neurogenesis; neuronal; neuronal circuitry; neuronal progenitor; neuronal progenitor cells; neuronal survival; newborn human (0-6 weeks); newborn neuron; novel; public health relevance; regenerate; relating to nervous system; research study; response; social role; therapeutic target; transgenic; voltage",Newborn Neurons in the Adult Hippocampal Network," Narrative The goal of this project is to elucidate, at the single cell and circuit level, how experience regulates neurogenesis by controlling the survival of newborn neurons. Impaired survival of adult generated neurons has been implicated in many neuropathological conditions including neurodegenerative diseases and psychiatric illnesses, thus these results will also provide insight into potential therapeutic targets to promote the survival of newborn neurons in disease states.",64025,NCF,Neurogenesis and Cell Fate Study Section,,2,314016,
7760537,R01,NS,5,,03/01/2010,02/28/2011,PA-07-140,5R01NS064030-02,,NINDS:336506;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PHILADELPHIA,UNITED STATES,NEUROLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"RAIZEN, DAVID MENASSAH;",1875475;,5R01NS064030,03/01/2009,02/28/2014,"3'5'-cyclic ester of AMP; Ablation; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Afferent Neurons; Alcohols, Octyl; Animal Model; Animal Models and Related Studies; Animals; Anthelone U; Autoregulation; Behavior; Behavioral; Biological Models; C elegans; C.elegans; Caenorhabditis elegans; Cell Communication and Signaling; Cell Signaling; Chemicals; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Defect; Diagnosis; EGF; Ecdysis; Electromagnetic, Laser; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Figs; Figs - dietary; Gene Arrangement; Gene Order; Gene Position; GeneHomolog; Generalized Growth; Genes; Genetic; Genetic Algorithm; Genetic Alteration; Genetic Change; Genetic Models; Genetic Programming; Genetic Screening; Genetic analyses; Genetic defect; Genetics-Mutagenesis; Goals; Grant; Growth; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase; Guanosine Cyclic Monophosphate; Guanosine Cyclic Monophosphate-Dependent Protein Kinases; Guanosine, cyclic 3',5'-(hydrogen phosphate); Heptylcarbinols; Homeostasis; Homolog; Homologous Gene; Homologue; Human Urinary Gastric Inhibitor; Hydroxyoctanes; Intracellular Communication and Signaling; Lasers; Life Cycle; Life Cycle Stages; Light; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular; Molecular Biology, Mutagenesis; Molting; Mutagenesis; Mutation; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurons, Afferent; Neurons, Sensory; Octanols; Octylic Alcohols; Operation; Operative Procedures; Operative Surgical Procedures; PDE; PKG; Patients; Phase; Phenotype; Phosphodiesterases; Photoradiation; Phylogenetic Analysis; Phylogenetics; Physiological Homeostasis; Property; Property, LOINC Axis 2; Protein Kinase G; Public Health; Radiation, Laser; Regulation; Research; Response Latencies; Rest; Sensory; Sensory Cell Afferent Neuron; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sleep; Sleep Deprivation; Sleep Disorders; Staging; Stream; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Time; Tissue Growth; Transgenic Organisms; Urogastrone; Wakefulness; Wakefulnesses; adenosine 3'5' monophosphate; beta-Urogastrone; biological signal transduction; cAMP; cGMP; cGMP kinase; cGMP-Dependent Protein Kinases; experiment; experimental research; experimental study; gain of function; genetic analysis; genome mutation; guanosine 3'5' monophosphate; improved; life course; model organism; mutant; neuronal; onset of sleep; ontogeny; phosphoric diester hydrolase; public health medicine (field); public health relevance; research study; response; sensory gating; sleep control; sleep onset; sleep problem; sleep regulation; surgery; transgenic",Regulation of sleep-like behavior in C. elegans," PROJECT NARRATIVE Sleep disorders and sleep deprivation are major unmet public health problems. This proposal aims to add to our understanding of sleep regulation, in order to enhance the diagnosis and treatment of patients with sleep disorders.",64030,BRS,Biological Rhythms and Sleep Study Section,,2,336506,
7767671,R01,NS,5,,02/01/2010,01/31/2011,PA-08-052,5R01NS064404-02,,NINDS:342629;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,SEATTLE,UNITED STATES,BIOMEDICAL ENGINEERING,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"PUN, SUZIE H;",8016168;,5R01NS064404,02/15/2009,01/31/2013,"21+ years old; 3' Untranslated Regions; 3'UTR; Adult; Affect; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Anthelone U; Antibodies; Apoplexy; Artificial Genes; Assay; BDNF; Bacterial DNA; Bioassay; Biocompatible; Biodistribution; Biologic Assays; Biological Assay; Brain; Brain Diseases; Brain Disorders; Brain-Derived Neurotrophic Factor; CNS Diseases; CNS disorder; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Locomotion; Cell Migration; Cell Movement; Cell Multiplication; Cell Proliferation; Cell division; Cell/Tissue, Immunohistochemistry; CellLine; Cells; Cellular Migration; Cellular Proliferation; Central Nervous System Diseases; Central Nervous System Disorders; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Charge; Clinical; Confocal Microscopy; Coon's Technic; Coon's Technique; Cytofluorometry, Flow; Cytolysis; DNA; DNA Sequence; DNA, Bacterial; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Development; Disease; Disorder; Dose; EGF; Elements; Encapsulated; Encephalon; Encephalon Diseases; Encephalons; Engineering; Engineerings; Epidermal Growth Factor; Epidermal Growth Factor-Urogastrone; Extravasation; FRET; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Fluorescence; Fluorescence Resonance Energy Transfer; Fluorescent Antibody Technic; Fluorescent Antibody Technique; Fluorescent Antinuclear Antibody Test; Forecast of outcome; GFAC; Gene Delivery; Gene Transfer; Generations; Genes; Genes, Reporter; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human Urinary Gastric Inhibitor; Human, Adult; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; IHC; Idiopathic Parkinson Disease; Image; Immunofluorescence Technic; Immunofluorescence Technique; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Luciferase; In Vitro; Injection of therapeutic agent; Injections; Injections, Intraventricular; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Intraventricular; Intraventricular Injections; Kinetic; Kinetics; Label; Lateral Ventricle of Brain; Lateral Ventricles; Lateral ventricle structure; Leakage; Lewy Body Parkinson Disease; Liposomal; Liposomes; Luciferases; Lysis; MGC34632; MTGN; Macrogols; Mammalian Cell; Mammals, Mice; Mediating; Membrane; Mice; Microfluorometry, Flow; Microscopy, Confocal; Mitogens; Modeling; Molecular Weight; Monitor; Mother Cells; Motility; Motility, Cellular; Murine; Mus; NPC; NRVS-SYS; Natural regeneration; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neural Growth; Neural Stem Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Organ System; Neuronal Differentiation; Neuronal Growth; Neurons; Non-Viral Vector; Nuclear Pore Complex; Nucleic Acids; PEG; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Particle Size; Patients; Peptides; Phenotype; Physical condensation; Plasmid Cloning Vector; Plasmid Vector; Plasmids; Polyethylene Glycols; Polyethylene Oxide; Polyethyleneoxide; Polymers; Polyoxyethylenes; Population; Primary Parkinsonism; Primary Senile Degenerative Dementia; Procedures; Progenitor Cells; Prognosis; Progressive Chorea, Hereditary, Chronic (Huntington); Proliferating; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Pump; Recovery; Regeneration; Relative; Relative (related person); Reporter; Reporter Genes; Safety; Screening procedure; Series; Site; Sodium Chloride; Sodium chloride (NaCl); Spillage; Spinal Column; Spine; Staining method; Stainings; Stains; Stem cells; Stroke; Surface; Synthetic Genes; System; System, LOINC Axis 4; Technology; Testing; Time; Toxic effect; Toxicities; Transfection; Transgenes; Urogastrone; Vascular Accident, Brain; Ventricular; Vertebral column; Viral; Work; adult human (21+); backbone; base; beta-Urogastrone; biocompatibility; biocompatible polymer; biomaterial compatibility; brain attack; brain tissue; cell motility; cell type; cerebral vascular accident; condensation; cultured cell line; dementia of the Alzheimer type; disease/disorder; disulfide bond; flow cytophotometry; fluorescent antibody; fluorophore; imaging; improved; in vivo; interest; lateral ventricle; light scattering; membrane structure; methacrylamide; migration; nano particulate; nanoparticulate; nerve stem cell; neural; neural progenitor cells; neurodegenerative illness; neurogenesis; neuronal; neuronal progenitor; neuronal progenitor cells; non-viral gene delivery; nonviral gene delivery; outcome forecast; palliative; particle; primary degenerative dementia; public health relevance; regenerate; relating to nervous system; salt; screening; screenings; senile dementia of the Alzheimer type; site targeted delivery; stem; stroke; subventricular zone; targeted delivery; therapeutic gene; therapeutic target; trafficking; transfer of a gene; transgene expression; uptake; vector",Non-viral gene delivery to neural progenitor cells in the SVZ," Project Narrative Neurogenerative diseases of the brain, such as Alzheimer's Disease, Huntington's Disease, and Parkinson's Disease, affect over 20 million people worldwide, and most current treatments for these diseases are palliative rather than restorative. One promising treatment approach to neurodegenerative disorders is the manipulation of neural stem and progenitor cells in the adult human nervous system to restore lost neuronal populations. The goal of this work is to develop synthetic gene delivery vectors that can be used to specifically deliver growth factors to neural progenitor cells in the brain in order to stimulate neurogenesis. The proposed approach involves incorporating bioactive peptides in the polymeric vector to promote targeting to the neural progenitor cells and efficient intracellular delivery. The developed technology would have broad significance as vehicles to deliver therapeutic genes for CNS disorders.",64404,GDD,Gene and Drug Delivery Systems Study Section,,2,342629,
7762826,R01,NS,5,,02/15/2010,02/14/2011,PA-07-070,5R01NS064592-02,,NINDS:343252;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BUFFALO,UNITED STATES,ENGINEERING (ALL TYPES),26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"MENG, HUI ;",7611538;,5R01NS064592,02/15/2009,01/31/2014,"Aneurysm; Angiogram; Angiography; Apoptosis; Apoptosis Pathway; Bilateral; Biological; Blood flow; Cell Death, Programmed; Cerebral Arterial Circle; Circle of Willis; Closure by Ligation; Dependence; Development; Diagnostic; Dose; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Evaluation; Event; Generalized Growth; Growth; Hepatocyte Nitric Oxide Synthase; Histology; INOS; Inducible Nitric Oxide Synthase; Intracranial Aneurysm; Leiomyocyte; Ligation; Liquid substance; Location; MMPs; Macrophage Nitric Oxide Synthase; Mammals, Rabbits; Maps; Matrix Metalloproteinases; Measurement; Mediating; Modeling; Molecular; Mononitrogen Monoxide; Morbidity; Morbidity - disease rate; Morphology; Mortality; Mortality Vital Statistics; Myocytes, Smooth Muscle; NOS Type II; NOS2; NOS2A; NOS2A protein, human; Nitric Oxide; Nitric Oxide Synthase 2A; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Operation; Operative Procedures; Operative Surgical Procedures; Oryctolagus cuniculus; Pathogenesis; Pathologic; Patients; Peroxonitrite; Peroxonitrites; Peroxynitrites; Play; Prevention strategy; Preventive strategy; Production; Rabbit, Domestic; Rabbits; Risk Factors; Role; Rupture; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Surgical; Surgical Interventions; Surgical Procedure; Testing; Tissue Growth; Vascular remodeling; base; cerebrovascular; early onset; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; fluid; hemodynamics; human NOS2A protein; iNOS enzyme; improved; in vivo; liquid; nitric oxide synthase, Type II; ontogeny; peroxynitrite; prognostic; public health relevance; research study; response; shear stress; social role; surgery",Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms," Intracranial aneurysms have catastrophic consequences with high morbidity and mortality if they rupture. What causes intracranial aneurysms to develop is unclear, but blood flow (hemodynamics) conditions play an important role. This study seeks to elucidate the specific hemodynamic and biological mechanisms involved in initiating intracranial aneurysms in order to pave the way for improved diagnostic and prognostic capabilities and the development of more effective prevention strategies and less invasive therapies.",64592,BINP,Brain Injury and Neurovascular Pathologies Study Section,,2,343252,
7816672,R01,NS,5,,03/01/2010,02/28/2011,PA-07-070,5R01NS065205-02,,NINDS:310274;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,ENGINEERING (ALL TYPES),07,061364808,US,MD,21250,UNIVERSITY OF MARYLAND BALT CO CAMPUS,"LEACH, JENNIE B;",6672923;,5R01NS065205,05/01/2009,02/28/2013,"2-dimensional; 3-D structure; 3-dimensional structure; 3D structure; Adhesion Molecule; Adhesives; Apoplexy; Architecture; Behavior; Biochemical; Biocompatible; Biocompatible Materials; Biological; Biomaterials; Biopolymers; Body Tissues; Cell Adhesion Molecules; Cell Attachment; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Cell-Extracellular Matrix; Cell-Matrix Adhesions; Cell-Matrix Junction; Cells; Cellular Matrix; Cellular Morphology; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Cold-Insoluble Globulins; Controlled Environment; Cues; Cytoskeletal System; Cytoskeleton; Data; Diffusion; Dorsal Root Ganglia; ECM; Engineering; Engineering / Architecture; Engineerings; Environment; Environment, Controlled; Extracellular Matrix; Extracellular Matrix, Integrins; FADK; FAK; FAK1; FN1; FNZ; Fibronectin 1; Fibronectins; Future; Ganglia, Spinal; Gel; Glycoprotein GP-2; Goals; Hypoxia; Hypoxic; In Vitro; Integrins; Intracellular Communication and Signaling; Investigation; Knowledge; LETS Proteins; Laboratories; Laboratory Study; Laminin; Large External Transformation-Sensitive Protein; Ligands; Mammals, Mice; Measurement; Measures; Methods; Mice; Morphology; Murine; Mus; Myelopathy, Traumatic; Nerve; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neurites; Neurobiology; Neurocyte; Neurons; Normal Tissue; Normal tissue morphology; O element; O2 element; Opsonic Glycoprotein; Opsonic alpha(2)SB Glycoprotein; Outcome; Oxygen; Oxygen Deficiency; PTK2; PTK2 gene; Peptides; Performance; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiology; Play; Process; Property; Property, LOINC Axis 2; Reporter; Role; Science of neurophysiology; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Spinal Cord Trauma; Spinal Ganglia; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stroke; System; System, LOINC Axis 4; Testing; Tissues; Translating; Translatings; VCL; Vascular Accident, Brain; Vinculin; Vinculin (Caenorhabditis elegans clone pRB9.1 protein moiety reduced); Work; Wound Healing; Wound Repair; alpha 2-Surface Binding Glycoprotein; artificial environment; base; biological signal transduction; brain attack; cell adhesion protein; cell morphology; cell type; cerebral vascular accident; density; design; designing; dorsal root ganglion; experiment; experimental research; experimental study; improved; in vivo; intracellular skeleton; language translation; neural; neurobiological; neuronal; neuronal survival; neurophysiology; next generation; novel; physical property; pp125FAK; public health relevance; relating to nervous system; repair; repaired; research study; response; scaffold; scaffolding; social role; stroke; success; three dimensional structure; tissue repair; tool; two-dimensional",Microenivironment Dimensionality Modulates Neuronal Signaling," PROJECT NARRATIVE Much of our current understanding of neurobiology relies on disrupted tissues, laboratory studies in artificial environments, and clinical observations. We hypothesize that the next generation of nerve repair therapies relies on the design of materials that better replicate the three-dimensional structure and physiology of native tissues. The goals of this proposed work is to advance the understanding of neuronal response to three-dimensional environments and to provide new improved materials and tools to study and repair neurons.",65205,NT,Neurotechnology Study Section,,2,310274,
7758240,R03,AG,5,,02/01/2010,12/31/2010,PA-06-180,5R03AG031944-03,,NIA:62103;,2010,NATIONAL INSTITUTE ON AGING,,DAVIS,UNITED STATES,PHARMACOLOGY,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHEN-IZU, YE ;",6304472;,5R03AG031944,01/15/2009,12/31/2010,"21+ years old; ATP phosphohydrolase (Ca(2+)-transporting); Address; Adenosine Triphosphatase, Calcium; Adult; Affect; Age; Aging; Animal Model; Animal Models and Related Studies; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Apoplexy; Blood Pressure, High; Blood Pressure, Low; Blotting, Western; C protein; CALM; CALM1; CALM2; CAM1; CBP protein (citrate-binding); Ca Release Channel-Ryanodine Receptor; Ca(2+)-Transporting ATPase; Ca2+ ATPase; Ca2+ transporting ATPase; Calcium ATPase; Calcium Adenosinetriphosphatase; Calcium Pump; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calcium-Ryanodine Receptor Complex; Calmodulin; Calmodulin 1; Calmodulin 1 (Phosphorylase Kinase, Delta); Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cell/Tissue, Immunohistochemistry; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinical; Coupling; Development; Disease; Disease model; Disorder; EC 2.7; ECG; EKG; Echocardiogram; Echocardiography; Electrocardiogram; Electrocardiography; Essential Hypertension; Freezing; Future; Gender; Gene Transcription; Generalized Growth; Genetic Transcription; Goals; Growth; HTRPY; Heart; Heart Diseases; Heart Hypertrophy; Heart failure; Human; Human, Adult; Human, General; Hypertension; Hypertrophy; Hypotension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; Inbred SHR Rats; Incidence; Ion Channel; Ionic Channels; Isoforms; Kinases; L-Threonine; Man (Taxonomy); Man, Modern; Measurement; Measures; Membrane Channels; Methods; Molecular; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardium; Nuclear; Patients; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phosphorylation; Phosphotransferases; Pilot Projects; Play; Population; Prevalence; Protein Isoforms; Protein Phosphorylation; Proteins; RNA Expression; Rats, Inbred SHR; Rats, SHR; Rats, Spontaneously Hypertensive; Receptors, Ryanodine; Risk Factors; Role; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Senescence; Severities; Site; Staging; Stroke; System; System, LOINC Axis 4; Testing; Threonine; Time; Tissue Growth; Tissue Sample; Transcription; Transcription, Genetic; Translational Research; Translational Research Enterprise; Translational Science; Transphosphorylases; Transthoracic Echocardiography; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular Hypotensive Disorder; Ventricular Arrhythmia; Western Blotting; Western Blottings; Western Immunoblotting; adult human (21+); aging population; brain attack; calcium transporting ATPase; cardiac failure; cardiac hypertension; cardiac hypertrophy; cardiac infarct; cardiac muscle; cerebral vascular accident; citrate carrier; citrate periplasmic carrier protein; citrate transporter; citrate-binding transport protein; clinical relevance; clinically relevant; coronary attack; coronary infarct; coronary infarction; disease/disorder; disorder model; effective therapy; enzyme activity; gene product; heart attack; heart disease hypertension; heart disorder; heart disorder hypertension; heart function; heart hypertension; heart infarct; heart infarction; heart muscle; heart sonography; hemodynamics; high risk; hyperpiesia; hyperpiesis; hypertensive cardiomyopathy; hypertensive disease; hypertensive heart disease; hypertensive heart disorder; idiopathic hypertension; in vivo; inhibitor; inhibitor/antagonist; model organism; new therapeutics; next generation therapeutics; novel therapeutics; ontogeny; phospholamban; pilot study; prevent; preventing; primary hypertension; protein blotting; protein expression; public health relevance; senescent; social role; sound measurement; spontaneous hypertensive rat; stroke; translation research enterprise; treatment effect; treatment strategy; tricarboxylate carrier; tricarboxylate transporter; tricarboxylate-binding C protein; ventricular hypertrophy",CaMKII Inhibition as a New Therapeutic Strategy for Treating Hypertension-induced," NARRATIVE High blood pressure is a major risk factor for developing heart diseases. This project proposes to conduct a pilot study to explore the feasibility and the potential of inhibiting CaMKII in the heart as a new strategy for treating hypertensive heart disease. We will first conduct the pilot study using an animal model (spontaneously hypertensive rat) that mimics human clinical stages. The long term goal is to develop effective treatment for hypertension-induced hypertrophy, arrhythmias, and heart failure in human patients.",31944,CCHF,"Cardiac Contractility, Hypertrophy, and Failure Study Section",,3,62103,
7769492,R03,AG,5,,02/01/2010,01/31/2011,PA-06-180,5R03AG033221-02,,NIA:64538;,2010,NATIONAL INSTITUTE ON AGING,,ITHACA,UNITED STATES,PSYCHOLOGY,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"FERGUSON, MELISSA J;",6303687;,5R03AG033221,02/15/2009,01/31/2011,"Address; Affective; Categories; Development; Diagnosis; Doctor of Philosophy; Evaluation; Food; Funding; Goals; Informal Social Control; Investigators; Knowledge; Length of Life; Longevity; Measures; Melissa; Memory; Mental Health; Mental Hygiene; Motivation; Persons; Ph.D.; PhD; Population; Process; Psychological Health; Reporting; Research; Research Personnel; Researchers; Role; Self Regulation; Social Control, Informal; Stimulus; Time; Universities; Work; abstracting; experience; falls; life span; lifespan; meetings; motivated behavior; psychologic; psychological; public health relevance; social role; success",The Role of Implicit Evaluations in Goal Pursuit and Self-regulation,"  Project Relevance  An increased understanding of the psychological processes underlying effective self-regulation has tremendous implications for the field of mental health (e.g., Baumeister & Heatherton, 1996; Heatherton & Ambady, 1993; Higgins, 1997; Metcalfe & Mischel, 1999). The current proposed work addresses significant theoretical as well as practical questions related to implicit evaluative processing in self-regulation, and holds considerable translational value in terms of applications to both diagnosis and treatment within the mental health field. This work also has the potential to inform the further development of an extensive research agenda on this topic from a lifespan perspective.",33221,SPIP,"Social Psychology, Personality and Interpersonal Processes Study Section",,2,64538,
7900618,R03,AI,5,,02/01/2010,01/31/2011,PA-06-180,5R03AI072538-03,,NIAID:67271;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GALVESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"GARG, NISHA JAIN;",3133113;,5R03AI072538,02/01/2008,01/31/2011,"ASP-1; ATGN; Adjuvant; Alleles; Allelomorphs; American; American Trypanosomiasis; American trypanosome; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Antigenic Determinants; Antigens; Approaches to prevention; Area; Asparaginase II; Asparagine Deaminase; Binding Determinants; Blood; Body Tissues; Canine Species; Canis familiaris; Cardiac; Cardiomyopathies; Cause of Death; Cell Mediated Immunology; Cell-Mediated Immunity; Cellular Immunity; Cessation of life; Chagas Disease; Clinical; Colaspase; Collaborations; Computer Analysis; DNA; DNA Vaccines; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Death; Deoxyribonucleic Acid; Development; Disease; Disorder; Dogs; Edodekin Alfa; Epitopes; Evaluation; Foreign Component; Foreign Subpart; Foreign or Foreign Component; Funding; Future; GM-CSF; GMCSF; Genes; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine-Producing Cell-Stimulating Factor; Household; Housing; Human; Human, General; IL-12; IL12; Immune response; Immunity; Immunity, Cellular; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Incidence; Individual; Infection; Insect Vectors; Insecta; Insects; Interleukin-12; International Activity; International Affairs; International Aspects; Invertebrates, Insects; Knowledge; L asparagine amidohydrolase; L-ASP; L-Asparaginase; LY6E; LY6E gene; Lcf-ASP; Mammalia; Mammals; Mammals, Dogs; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Methods; Mexico; Mice; Modeling; Molgramostin; Monitor; Multinational Aspects; Murine; Mus; Mycocardium Disease; Myocardial Diseases; Myocardial Disorder; Myocardiopathies; NKSF; Naked DNA Vaccines; Natural Killer Cell Stimulatory Factor; Parasitemia; Parasites; Parasitic Diseases; Plasmids; Population; Position; Positioning Attribute; Prevalence; Prevention approach; Proteins; RIG-E; RIGE; Reagent; Recombinant Vaccines; Recombinants; Regulation; Research Resources; Resistance; Resistance to infection; Resources; Reticuloendothelial System, Blood; Risk; Route; SCA-2; SCA2; Sensitization, Immunologic; Sensitization, Immunological; Serasa; Symptoms; T. cruzi; TC-GM-CSF; TSA-1; Testing; Tissues; Transmission; Trypanosoma cruzi; Trypanosomiasis; Trypanosomiasis, South American; Tumor-Cell Human GM Colony-Stimulating Factor; Vaccinated; Vaccination; Vaccines; Vaccines, DNA; Vaccines, Recombinant DNA; Veterinarians; adult youth; animal facility; asparaginase; base; canine; clinical data repository; clinical data warehouse; communicable disease transmission; computational analysis; cytokine; data repository; disability; disease transmission; disease/disorder; domestic dog; efficacy testing; enzootic; experience; field study; gene product; granulocyte macrophage colony stimulating factor; host response; human disease; immunogen; immunogenicity; immunoresponse; infection resistance; infectious disease transmission; model organism; myocardium disorder; new vaccines; next generation vaccines; novel; novel vaccines; parasaetemia; prophylactic; relational database; resistant; response; sucking; transmission process; vaccine candidate; vaccine efficacy; vector; vector control; young adult",Testing DNA Vaccine Against T. cruzi in Large Animal Model (Dogs),,72538,VMD,Vaccines Against Microbial Diseases Study Section,,3,67271,
7758802,R03,AI,5,,02/01/2010,01/31/2011,PA-06-180,5R03AI078001-02,,NIAID:72518;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GAINESVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"LORCA, GRACIELA ;",9047337;,5R03AI078001,02/01/2009,01/31/2011,"ATGN; Adjuvant; Adopted; Affinity; Agreement; Alimentary Canal; Animal Model; Animal Models and Related Studies; Antibiotic Resistance; Antigens; Aromatic Compounds; Bacillus; Bacillus (bacterium); Bacteria; Band Shift Mobility Assay; Bandshift Mobility Assay; Biliary or Urinary Stones; Binding; Binding (Molecular Function); Binding Sites; Calculi; Calorimetry; Chemicals; Clostridium; Collaborations; Combining Site; Computer Simulation; Computerized Models; D-Glucose, 4-O-beta-D-galactopyranosyl-; DNA; DNA Binding; DNA Binding Interaction; DNA-Protein Interaction; Data; Deoxyribonucleic Acid; Development; Digestive Tract; Drug Delivery; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug Targeting; Drug Targetings; Drugs; Electrophoretic Mobility Shift Assay; Environment; Family; Food Industry; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Expression; Gene Targeting; Genome; Genus staphylococcus; Goals; Grant; Health Food; High Throughput Assay; Human; Human, General; Immune response; In Vitro; Infection; Innovative Therapy; Investigators; Lactobacillus; Lactose; Learning; Life; Ligands; Listeria; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Mobility Shift Assay; Models, Computer; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Multi-Drug Resistance; Multi-drug Resistance Induction; Multi-drug Resistant Induction; Multidrug Resistance; Multidrug Resistance Induction; Multidrug Resistant Induction; Outcome; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Population; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Binding; Proteins; Public Health; Publications; R01 Mechanism; R01 Program; RPG; Reactive Site; Recombinants; Regulation; Regulatory Protein; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistance to antibiotics; Resistance, Antibiotic; Resistant to Multiple Drug; Resistant to antibiotics; Resistant to multi-drug; Resistant to multidrug; Resources; Scientific Publication; Screening Result; Screening procedure; Simulation, Computer based; Solutions; Staphylococcus; Stone; Streptococcus; Study Type; System; System, LOINC Axis 4; Targetings, Gene; Technology; Testing; Therapy, Innovative; Titrations; Toxic effect; Toxicities; Training; Vaccine Antigen; Vaccines; Work; alimentary tract; anti-microbial agent; anti-microbial drug; antibiotic resistant; antimicrobial agent; antimicrobial drug; bacteria vector; bacterial vector; base; combat; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; design; designing; digestive canal; drug/agent; efflux pump; experiment; experimental research; experimental study; functional genomics; gel shift assay; gene product; genetic regulatory protein; genome sequencing; high throughput screening; high throughput technology; host response; immunogen; immunoresponse; in silico; in vivo; innovate; innovation; innovative; meetings; model organism; multi-drug resistant; multidrug resistant; pathogenic bacteria; protein purification; public health medicine (field); public health relevance; regulatory gene product; research study; screening; screenings; small molecule; small molecule libraries; study design; tool; transcription factor; vector; virtual simulation",Identification of New Lactobacillus Regulators Responsive to FDA-Approved Drugs, The proposed research is relevant to the public health because our long-term goal is to increase the efficacy with which vaccine antigens can be delivered using Lactobacillus vectors. The finding of new vectors that can be controlled by already-approved small molecules for its use in humans is exceptionally relevant to public health since it will impact in the development of cheaper and safer vaccines that could be easily administer to large populations.,78001,GDD,Gene and Drug Delivery Systems Study Section,,2,72518,
7768502,R03,AI,5,,02/01/2010,01/31/2011,PA-06-180,5R03AI080805-02,,NIAID:75838;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,AURORA,UNITED STATES,BIOCHEMISTRY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"DAVIS, RICHARD E.;",1948513;,5R03AI080805,02/15/2009,01/31/2011,"0-11 years old; Address; Affinity; Area; Ascaris; Assay; Bilharzia; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; C elegans; C.elegans; Caenorhabditis elegans; Cap Binding Proteins; Child; Child Youth; Children (0-21); Cognitive; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Data; Developing Countries; Developing Nations; Development; Drug Delivery; Drug Delivery Systems; Drug Design; Drug Targeting; Drug Targetings; Drug resistance; Economics; Exhibits; Future; Gene Expression; Genetics-Mutagenesis; Goals; Helminths; Homology Modeling; Human, Child; Infection; Initiation Factors; Isoforms; Lead; Less-Developed Countries; Less-Developed Nations; Ligands; Messenger RNA; Molecular Biology, Mutagenesis; Molecular Interaction; Morbidity; Morbidity - disease rate; Mutagenesis; NMR Spectroscopy; Parasites; Parasitic infection; Pb element; Peptide Initiation Factors; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Public Health; RNA Cap-Binding Proteins; RNA Splicing; RNA, Messenger; RNA, Spliced Leader; Resolution; SL RNA; Schistosoma; Schistosome; Sequence Alignment; Single Crystal Diffraction; Social Development; Spectroscopy, NMR; Spliced Leader; Spliced Leader RNA; Spliced Leader Sequences; Splicing; Structure; Substrate Specificity; Testing; Third-World Countries; Third-World Nations; Trans RNA Splicing; Trans Spliced Leader Sequences; Trans-Splicing; Translation Initiation; Translation Initiation Factor; Translational Initiation Factor; Translations; Under-Developed Countries; Under-Developed Nations; Worms, Parasitic; X Ray Crystallographies; X-Ray Crystallography; analog; base; capping of mRNA; children; combat; design; designing; drug resistant; flexibility; gene product; heavy metal Pb; heavy metal lead; insight; mRNA; mRNA Cap Binding Proteins; mRNA capping; new therapeutics; next generation therapeutics; novel therapeutics; nuclear magnetic resonance spectroscopy; public health medicine (field); public health relevance; resistance to Drug; resistant to Drug; socioeconomic; socioeconomically; socioeconomics; youngster",Structural Analysis of Helminth mRNA Cap-Binding Proteins," Narrative  Parasitic helminths remain a significant public health problem in many parts of the world and hinder socioeconomic development in endemic areas. We will carry out structural analyses of an essential parasite protein, eIF4E, with unique substrate specificity for the mRNA cap to evaluate this protein as a potential target for new and novel therapeutics against parasitic helminths.",80805,PTHE,Pathogenic Eukaryotes Study Section,,2,75838,
7772292,R03,AI,5,,02/01/2010,01/31/2011,PA-06-180,5R03AI082316-02,,NIAID:77220;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"TOTTEN, PATRICIA A;",1892927;,5R03AI082316,02/20/2009,01/31/2011,"Abdomen; Abdominal; Abdominal Wall; Abdominal wall structure; Adhesins, Bacterial; Animal Model; Animal Models and Related Studies; Animals; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigen Variation; Antigenic Variability; Antigenic Variation; Archives; Autologous; Bacteria; Bacterial Adhesins; Blood Serum; Body Tissues; Cannot achieve a pregnancy; Cells; Cellular Infiltrate; Cervicitis; Cervix; Cervix Uteri; Chimp; Chimpanzee; Chlamydia trachomatis; Chronic; Cloning; Confocal Microscopy; DNA; Data; Deoxyribonucleic Acid; Detection; Development; Difficulty conceiving; Disease; Disease Association; Disorder; Endometritis; Evaluation; Evolution; Fallopian Tubes; Female; Funding; Future; Generalized Growth; Generations; Genes; Genital; Genital System, Female, Cervix; Genital System, Female, Vagina; Genital system; Gonococcus; Growth; H. ducreyi; H.ducreyi; Haemophilus ducreyi; Harvest; Hemophilus ducreyi; Housing; Immune; Immune response; Immunobiology; Immunoglobulin V; Immunoglobulin Variable Region; Immunophysiology; Implant; In Vitro; Individual; Infection; Infection prevention; Infertility; Inflammatory; Investigators; Laboratories; Lead; Leucocytic infiltrate; Location; M. genitalium; M.genitalium; Macaca; Macaca nemestrina; Macaque; Mammalian Oviducts; Mammals, Primates; Medicine; Methods and Techniques; Methods, Other; Microscopy, Confocal; Modeling; Molecular; Monkey, Pigtail; Monkey, Pigtailed; Mycoplasma genitalium; N. gonorrhoeae; N.gonorrhoeae; Nature; Neisseria gonorrhoeae; Organism; Oviducts; Pan; Pan Genus; Pan Species; Pathogenesis; Pathogenicity Factors; Pb element; Pelvic Inflammatory Disease; Pig-Tailed Monkey; Pigtail Macaque; Premature Birth; Pressure; Pressure- physical agent; Preterm Birth; Prevalence; Prevent infection; Prevention strategy; Preventive strategy; Primates; Proteins; RT-PCR; RTPCR; Reagent; Research; Research Personnel; Research Specimen; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Rickettsia trachomae; Role; Salpingitis; Salpinx; Science of Medicine; Serum; Site; Specimen; Sterility; Study models; Surface; Syndrome; T. vaginalis; Techniques; Testing; Time; Tissue Growth; Tissues; Trichomonas vaginalis; Universities; Urethra; Urethritis; Uterine Cervix; Uterine Tubes; Vagina; Vaginal; Variable Region; Variable Region, Ig; Variant; Variation; Virulence Factors; Washington; Woman; abdominal wall; adhesin; animal Oviduct; antibody biosynthesis; chronic pelvic pain; chronic pelvic pain syndrome; clinical significance; clinically significant; cytokine; disease characteristic; disease/disorder; experiment; experimental research; experimental study; extracellular; fimbria; gene product; heavy metal Pb; heavy metal lead; host response; human disease; immunogenic; immunoglobulin biosynthesis; immunoresponse; in vivo; infertile; living system; microbicidal; microbicide; model development; model organism; novel; ontogeny; oviduct; pathogen; premature childbirth; premature delivery; pressure; preterm delivery; public health relevance; reproductive; research study; response; reverse transcriptase PCR; social role; sterile; subcutaneous; success; unable to bear children; urethral; urogenital system (genital part)",Salpingeal infection model of Mycoplasma genitalium," Project Narrative Mycoplasma genitalium is a newly recognized sexually transmitted pathogen with a prevalence and significance that rivals that of Chlamydia trachomatis and Neisseria gonorrhoeae. Little is known about the mechanisms used by this bacterium to elicit disease, in part because suitable animal models have not been developed for this pathogen. Importantly, this organism has developed a potential mechanism of antigenic variation that may explain its ability to persist in infected individuals to cause chronic infections. We propose to develop a primate model to study the immunobiology of M. genitalium infection, using techniques that have been highly successful for the study of C. trachomatis. This model, developed at the Washington National Primate Research Center (WaNPRC), will provide a unique opportunity to study the host/bacterial interactions of M. genitalium in an animal and in tissues most closely related to human disease. Further, development of this model will provide future opportunity to assess strategies for prevention and treatment of this emerging pathogen.",82316,ZRG1,Special Emphasis Panel,,2,77220,
7777307,R03,AR,5,,01/01/2010,12/31/2010,PAR-06-383,5R03AR057150-02,,NIAMS:68370;,2010,NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES,,IRVINE,UNITED STATES,DERMATOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"GANESAN, ANAND K;",8588234;,5R03AR057150,03/01/2009,12/31/2011,"Age related macular degeneration; Anabolism; Assay; Auditory; Autophagocytosis; Autophagosome; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Cells; Chloasma; Chloasmas; Coupled; Cutaneous Disorder; Dermatoses; Disease; Disorder; Ear, Internal; Electron Microscopy; Eukaryote; Eukaryotic Cell; Event; Eye; Eyeball; Fibroblasts; Gene Targeting; Genes; Genes, Regulator; Human; Human, General; Idiopathic Parkinson Disease; In Vitro; Individual; Labyrinth; Lewy Body Parkinson Disease; Libraries; Lysosomes; Maculopathy, Age-Related; Man (Taxonomy); Man, Modern; Measures; Melanins; Melanogenesis; Melanoma Cell; Melanosomes; Melasma; Methods; Modeling; Monitor; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurons; Normal Cell; Normal Tissue; Normal tissue morphology; Organelles; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathogenesis; Pathway interactions; Physiologic; Physiological; Pigments; Primary Parkinsonism; Process; Production; Proteins; RNA, Small Interfering; Regulation; Regulator Genes; Role; Screening procedure; Skin; Skin Diseases; Skin Diseases and Manifestations; Small Interfering RNA; Sound; Sound - physical agent; Structure; System; System, LOINC Axis 4; Targetings, Gene; Transcriptional Regulatory Elements; UV irradiated; UV irradiation; UV irridated; Validation; Vitiligo; Waardenburg syndrome; Waardenburg's syndrome; abstracting; autophagy; base; biosynthesis; cell behavior; defined contribution; disease/disorder; eukaryotida; functional genomics; gene product; genome-wide; in vivo; inner ear; insight; keratinocyte; loss of function; melanocyte; nervous system disorder; neurological disease; neuronal; novel; pathway; public health relevance; regulatory gene; screening; screenings; senile macular disease; siRNA; skin disorder; social role; sound; therapeutic gene; therapeutic target; trafficking; trans acting element; ultra violet irradiation; ultraviolet irradiation; van der Hoeve Halbertsona Waardenburg syndrome",Dissecting the Impact of Autophagy Regulators on Melanogenesis in Normal Human Ce," Project Narrative (relevance) Melanin protects the skin, eyes, and neurologic system from toxic insults and is aberrantly regulated in skin disorders (melasma and vitiligo), neurologic disorders (Parkinson's disease), auditory disorders (Waardenburg's syndrome) and opthalmologic disorders (age related macular degeneration). Genome-wide siRNAi-based functional genomics recently determined that several known and putative autophagy regulators impact melanogenesis in human cells. In this proposal, we determine how regulators of autophagy also impact melanin production. Through these studies we will gain insight into the regulation of vesicular trafficking in melanocytes and how these processes impact melanogenesis.",57150,ZAR1,Special Emphasis Panel,,2,68370,
7759550,R03,CA,5,,02/01/2010,01/31/2011,PAR-08-055,5R03CA133095-02,,NCI:81860;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,DENTISTRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"WATANABE, KEIKO ;",1876458;,5R03CA133095,02/01/2009,01/31/2011,"ATP[{..}]protein-tyrosine O-phosphotransferase; Anaplastic T-Lymphocyte with Horseshoe-Shaped Nucleus; Anaplastic T-Lymphocyte with Kidney-Shaped Nucleus; Archives; BRK; Benign; Biopsy; Biopsy Sample; Biopsy Specimen; Blotting, Western; Body Tissues; Breast Tumor Kinase; Caliber; Cancer Causing Agents; Cancerous; Cancers; Carcinogens; Carcinoma; Carcinoma Cell; Cell Cycle Progression; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cellular Proliferation; Cellular Regulation; Characteristics; Clinical; Common Neoplasm; Common Tumor; Custom; Data; Development; Diameter; Dysplasia; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Early Diagnosis; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epithelial; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Excision biopsy; Excisional Biopsy; First Gap Phase; Follow-Up Studies; Followup Studies; G1 Phase; G1 period; Gap Phase 1; Goals; HEK3; Hallmark Cell; Hand; Incisional Biopsy; Keratotic Plaque; Kinases; Lesion; Leukoplakia; M Phase; M phase (cell cycle); Malignant; Malignant - descriptor; Malignant Cell; Malignant Epithelial Cell; Malignant Neoplasms; Malignant Oral Cavity Neoplasm; Malignant Oral Cavity Tumor; Malignant Oral Neoplasm; Malignant Tumor; Malignant Tumor of the Mouth; Malignant neoplasm of mouth; Mitosis; Mitosis Stage; Monitor; Mortality; Mortality Vital Statistics; Mouth Cancer; Nuclear; Oncogens; Open Biopsy; Oral; Oral Cancer; Oral Cavity Squamous Cell Carcinoma; Oral squamous cell carcinoma; Outcome; PTK; PTK Receptors; PTK6; PTK6 Protein Tyrosine Kinase 6; PTK6 gene product, human; Pattern; Phase; Phosphotransferases; Pre-Malignant; Premalignant; Prevention of Oral Cancer; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; RNA Binding; RNA-Binding Proteins; RTK; Receptor Protein-Tyrosine Kinases; Relative; Relative (related person); SCC of the Mouth; SCC of the Oral Cavity; SRC-associated p68 protein; Sam 68; Sam 68 protein; Sam68; Sam68 protein; Sampling; Screening for Oral Cancer; Screening procedure; Series; Smoke; Smoking; Squamous cell carcinoma of mouth; Src-associated in mitosis, 68 kDa; Staging; Structure; Testing; Tissue Arrays; Tissue Chip; Tissue Microarray; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Transphosphorylases; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine-Protein Kinase 6; Tyrosine-Protein Kinase BRK; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Western Blotting; Western Blottings; Western Immunoblotting; brk protein, human; cancer cell; cell growth regulation; dyscrasia; early detection; epithelial carcinoma; gene product; human breast tumor kinase; human protein tyrosine kinase brk; hydroxyaryl protein kinase; laser capture microdissection; malignancy; malignant mouth neoplasm; migration; mouth squamous cell carcinoma; neoplasm/cancer; non-receptor PTK brk, human; oral cancer early detection; oral cancer prevention; oral cavity epithelium; oral epithelia; oral epithelium; oral squamous carcinoma; precancerous; protein blotting; protein tyrosine kinase brk, human; screening; screenings; tool; tyrosyl protein kinase",Early Detection of Premalignant Lesions in Oral Cancer, Oral squamous cell carcinoma (oral SCC) is an aggressive cancer that is the sixth most common cancer in the world today. The mortality rate for oral SCC has remained approximately 50% for several decades. Thus the early detection of premalignant lesions is crucial in order to reduce the mortality rate. The current obstacle to early detection of oral cancer is that it is difficult to discriminate white lesions caused by smoking that become malignant from those which remain innocuous. This study will determine if there is a strong correlation between the expression pattern of the BRK/Sik protein and its relevance to progression to malignancy in early stages of oral cancer.,133095,ZCA1,Special Emphasis Panel,,2,81860,
7772382,R03,CA,5,,02/01/2010,01/31/2011,PAR-08-055,5R03CA136113-02,,NCI:77500;,2010,NATIONAL CANCER INSTITUTE,,ATLANTA,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"BOSTICK, ROBERD ;",1901127;,5R03CA136113,02/20/2009,01/31/2011,"(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol; 1 alpha,25-dihydroxycholecalciferol-24-hydroxylase; 1 alpha,25-dihydroxyvitamin D(3)-24-hydroxylase; 1,25-DC-24-hydroxylase; 1,25-dihydroxyvitamin D3 24-hydroxylase; 2'-deoxy-8-hydroxyguanosine; 24-hydroxylase cytochrome P-450; 25(OH)vitamin D-24-hydroxylase; 25-HC-24-hydroxylase; 25-OH-D3 23-hydroxylase; 25-hydroxy vitamin D2 24-hydroxylase; 25-hydroxycholecalciferol 23-hydroxylase; 25-hydroxycholecalciferol-24-hydroxylase; 25-hydroxyvitamin D 23-hydroxylase; 25-hydroxyvitamin D(3)-24-hydroxylase; 25-hydroxyvitamin D(3)-24R-hydroxylase; 25-hydroxyvitamin D3 23-hydroxylase; 8-OH-dG; 8-hydroxy-2'-deoxyguanosine; 8-hydroxydeoxyguanosine; 8-oxodGuo; 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-; Acids, Bile; Address; Analysis, Data; Antigen Identified by Monoclonal Antibody Ki-67; Antigen Ki67; Apoptosis; Apoptosis Pathway; Articulation; Assay; Autocrine Systems; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Basic Research; Basic Science; Bile Acids; Bioassay; Biologic Assays; Biological; Biological Assay; Biopsy; Blood; Blood Coagulation Factor IV; Blood Plasma; Blood Serum; Body Tissues; CAM 120/80; COCA2; COX-2; COX2; CYP24; Ca++ element; Cachectin; Cachectin-Tumor Necrosis Factor; Cadherin-1; Calciol; Calcium; Cancer Cause; Cancer Etiology; Cancers; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell/Tissue, Immunohistochemistry; Cessation of life; Chemoprevention; Chemopreventive; Chemopreventive Agent; Cholecalciferol; Clinical Trials; Clinical Trials, Unspecified; Coagulation Factor IV; Cola; Colon; Colon Cancer; Colon Carcinoma; Colon or Rectum; Colonic Carcinoma; Colorectal; Colorectal Adenoma; Colorectal Adenomatous Polyp; Colorectal Cancer; Colorectal Neoplasms; Consumption; Cysteine; Data; Data Analyses; Death; Development; Diet; Dietary Factors; Dietary Intervention; Differentiation Factor, B-Cell; Disulfides; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; E-Cadherin; Epithelial Calcium-Dependent Adhesion Protein; Epithelial-Cadherin; Epithelium; F2-Isoprostanes; FCC2; Factor IV; Funding; Future; GFAC; Gamma interferon; Genes; Genus Cola; Glutathione; Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HNPCC; HNPCC2; HPGF; Half-Cystine; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IFN-Gamma; IFN-beta 2; IFN-g; IFNB2; IFNG; IHC; IL-6; IL6 Protein; INFLM; Image Analyses; Image Analysis; Immunohistochemistry; Immunohistochemistry Staining Method; Inflammation; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 6 (Interferon, Beta 2); Interleukin-6; Intervention Trial; Joints; KIA; Ki-67 Antigen; L-Cysteine; Laboratories; Large Bowel Adenoma; Large Bowel Adenomatous Polyp; Large Intestine Adenoma; Large Intestine Neoplasm; Large Intestine Tumor; MGC5172; MGI-2; MIB-1; MIB-1 Antigen; MIB-1 Protein; MKI67; MKI67 Protein; MLH1; MLH1 gene; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measurement; Measures; Methods; Mucosa; Mucosal Tissue; Mucous Membrane; Myeloid Differentiation-Inducing Protein; Neoplasm of the Large Bowel; Nutrition Interventions; Nutritional; Nutritional Interventions; Observational Study; Oxidative Stress; PBO; PGG/HS; PGHS-2; PHS-2; PTGS2; PTGS2 gene; Parents; Pathway interactions; Patients; Persons; Pilot Projects; Placebo Control; Placebos; Plasma; Plasmacytoma Growth Factor; Prevention; Preventive; Proliferation-Related Ki-67 Antigen; Proteins; Questionnaires; ROC Analysis; Randomized; Recurrence; Recurrent; Reducing Agents; Reductants; Research; Resected; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Sampling; Serum; Serum, Plasma; Sham Treatment; Supplementation; Surrogate End Points; Surrogate Endpoint; TGF-Beta 1; TGF-Beta1; TGFB1; TGFB1 protein, human; TNF-alpha; Testing; Tissues; Transforming Growth Factor Beta 1; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor of the Large Bowel; Tumors, Colorectal; Uvomorulin; VIT D; Vitamin D; Vitamin D 3; Vitamin D3; Work; anticarcinogenic; autocrine; base; biomarker; calcitriol 24-hydroxylase; clinical investigation; colon carcinogenesis; colorectal neoplasia; cost; cytochrome P450(24); cytochrome P450cc24; disease risk; disorder risk; gamma-L-Glu-L-Cys-Gly; gamma-L-Glutamyl-L-Cysteinylglycine; gene product; hCOX-2; hMLH1; human TGFB1 protein; image evaluation; inflammatory marker; interferon beta 2; lFN-Gamma; malignancy; neoplasm/cancer; neoplastic; novel; paracrine; pathway; pilot study; randomisation; randomization; randomly assigned; rectal; response; sham therapy; transforming growth factor beta1; vitamin D 24-hydroxylase",Vitamin D/Calcium and Oxidative Stress and Inflammation Biomarkers," Narrative This study will allow the first tests of whether calcium and vitamin D can reduce excess oxidative stress and inflammation in humans, and the first tests of the usefulness of new measurements of oxidative stress and inflammation in humans for research on diet and the causes and prevention of colorectal and other cancers. This study offers a unique, cost-effective opportunity to investigate a new diet-colorectal cancer hypothesis in humans, and to validate new biological measurements that will open new opportunities for investigating cancer-preventive effects of calcium and vitamin D and other dietary factors, and whether such dietary factors may reduce risk for colorectal cancer.",136113,ZCA1,Special Emphasis Panel,,2,77500,
7761283,R03,DA,5,,02/01/2010,01/31/2011,PA-06-180,5R03DA022489-02,,NIDA:82665;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,TAMPA,UNITED STATES,,11,139301956,US,FL,336129497,H. LEE MOFFITT CANCER CTR & RES INST,"EVANS, DAVID E;",6768434;,5R03DA022489,02/01/2009,01/31/2011,"Address; Affect; Anterior; Area; Arousal; Attention; Autonomic nervous system; Behavioral; Brain; Brain imaging; Brain region; Cell Communication and Signaling; Cell Signaling; Central Lobe; Characteristics; Chronotropism, Cardiac; Chronotropisms, Cardiac; Cigarette; Cognitive; Cues; Dependence; Dependence, Nicotine; Development; Drug abuse; Drugs; Electrodermal Response; Emotions; Encephalon; Encephalons; Event; Exposure to; Functional Magnetic Resonance Imaging; GSR; Galvanic Skin Response; Heart Rate; Individual; Insula; Insula of Reil; Intracellular Communication and Signaling; Island of Reil; Knowledge; MRI, Functional; Magnetic Resonance Imaging, Functional; Medical Imaging, Positron Emission Tomography; Medication; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Motivation; Msec; Nervous; Nervous System, Brain; Neurobiology; Nicotine Dependence; Non-smoker; PET; PET Scan; PET imaging; PETSCAN; PETT; Participant; Patient Self-Report; Pharmaceutic Preparations; Pharmaceutical Preparations; Positron Emission Tomography Scan; Positron-Emission Tomography; Predisposition; Process; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Reaction Time; Reflex, Psychogalvanic; Relapse; Relative; Relative (related person); Research; Resolution; Response RT; Response Time; Role; Secondary to; Self-Report; Signal Transduction; Signal Transduction Systems; Signaling; Skin Electric Conductance; Smoke; Smoker; Smoking; Smoking Behavior; Source; Specificity; Structure; Susceptibility; Techniques; abuse of drugs; abuses drugs; addiction; base; biological signal transduction; brain visualization; cingulate cortex; craving; cue reactivity; design; designing; drug/agent; fMRI; imaging modality; improved; indexing; millisecond; neural; neurobiological; nicotine addiction; nonsmoker; psychomotor reaction time; public health relevance; relating to nervous system; response; social role; theories; treatment program",Automatic Attention to Smoking Cues: Neural Correlates,,22489,APDA,Adult Psychopathology and Disorders of Aging Study Section,,2,82665,
7759555,R03,DA,5,,02/01/2010,01/31/2011,PAS-07-327,5R03DA025939-02,,NIDA:249498;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MENLO PARK,UNITED STATES,,14,009232752,US,CA,940253493,SRI INTERNATIONAL,"JIANG, FAMING ;",9328494;,5R03DA025939,02/01/2009,01/31/2011,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 7-Azabicyclo(2.2.1)heptane, 2-(6-chloro-3-pyridinyl)-, exo-; Absence of pain sensation; Absence of sensibility to pain; Acetylcholine; Active Sites; Addiction, Drug; Affinity; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Arousal; Benzophenones; Binding; Binding (Molecular Function); Binding Sites; Biology; Biopolymers; Central Nervous System; Chemical Dependence; Chemistry, Pharmaceutical; Combining Site; DNA; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Deoxyribonucleic Acid; Dependence, Drug; Development; Diazirine; Diazomethane; Drug Addiction; Drug Dependency; Epilepsy; Epileptic Seizures; Epileptics; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Feels no pain; Goals; Idiopathic Parkinson Disease; In Vitro; Ion Channel; Ionic Channels; Laboratories; Lead; Learning; Lewy Body Parkinson Disease; Ligand Binding; Ligands; Literature; Maps; Medicinal Chemistry; Membrane Channels; Memory; Methane, diazo-; Molecular Interaction; Nerve Cells; Nerve Unit; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; No sensitivity to pain; Pain; Painful; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pb element; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Pharmacology; Photoaffinity Labels; Physiologic; Physiological; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Proteins; Reactive Site; Reader; Receptor Activation; Receptor Protein; Reporting; Research; Resistance; Rewards; Role; Seizure Disorder; Sequence Homology; Series; Sites, Active; Structure; Structure-Activity Relationship; Testing; analgesia; analog; base; chemical structure function; cognitive function; covalent bond; dementia of the Alzheimer type; design; designing; epibatidine; epilepsia; epileptiform; epileptogenic; fluorescence imaging; gene product; heavy metal Pb; heavy metal lead; homology (molecular); motor control; neurodegenerative illness; neuronal; novel; photoactivation; primary degenerative dementia; prototype; public health relevance; receptor; resistant; senile dementia of the Alzheimer type; social role; structure function relationship; tool; tool development",Development of photoaffinity ligands for the alpha3beta4 nicotinic acetylcholine ," Title: Development of photoaffinity ligands for the ¨3¨4 nicotinic acetylcholine receptors Project Narrative: The ¨3¨4 nicotinic acetylcholine receptor (nAChR) has been shown to play a role in drug addiction. However, its biology and pharmacology are not yet thoroughly understood. The basis of subtype selectivity for nAChR ligands is also not well-understood. This proposed project will develop ¨3¨4 photoaffinity ligands based on our recently discovered selective and potent lead compounds. These photoaffinity ligands will be useful tools to understand the structural basis of selectivity and rational design of ¨3¨4 nAChR for the treatment of drug addiction.",25939,ZRG1,Special Emphasis Panel,,2,249498,
7759556,R03,DA,5,,02/01/2010,01/31/2011,PAS-07-327,5R03DA025947-02,,NIDA:232506;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"PAIGE, MIKELL ;",9367141;,5R03DA025947,02/01/2009,01/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Abnormal Assessment of Metabolism; Acute; Addiction, Drug; Address; Affinity; Agonist; Alcohols; Animals; Area; Associative Learning; Biological; Blood - brain barrier anatomy; Blood-Brain Barrier; Brain Diseases; Brain Disorders; Cell Communication and Signaling; Cell Signaling; Chemical Class, Alcohol; Chemical Dependence; Chemicals; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Chronic; Cocaine; Cognitive Discrimination; Conditioning, Classical; Conditionings, Classical; Cues; Cyclic GMP; DA Neuron; Data; Dependence, Drug; Dependency; Dependency (Psychology); Development; Discrimination; Discrimination (Psychology); Dopamine; Dopamine neuron; Drug Addiction; Drug Dependency; Drug Synthesis and Chemistry; Drug abuse; Drugs; Electronics; Emotional; Encephalon Diseases; Evaluation; Event; Exposure to; Fore-Brain; Forebrain; Funding; Future; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Health; Hemato-Encephalic Barrier; Hydroxytyramine; Intake; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Ligands; Mediating; Medical; Medication; Mesencephalon; Metabolic Studies; Metabolism Studies; Mid-brain; Midbrain; Midbrain structure; Modification; Muscle Rigidity; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nicotine; Nucleus Accumbens; Oils; Pathway interactions; Pavlovian conditioning; Pharmaceutic Preparations; Pharmaceutical Preparations; Principal Investigator; Probability; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Rewards; Rigidity; Rigidity, Muscular; Signal Transduction; Signal Transduction Systems; Signaling; Social Problems; Surface; Symptoms; Therapeutic Agents; Ventral Tegmental Area; abuse of drugs; abused drugs; abuses drugs; addiction; analog; base; biological signal transduction; cGMP; classical conditioning; clinical applicability; clinical application; desensitization; design; designing; dopaminergic neuron; drug candidate; drug development; drug metabolism; drug of abuse; drug synthesis; drug/agent; drugs abused; drugs of abuse; emotional dependency; guanosine 3'5' monophosphate; improved; in vivo; interest; interventional strategy; meetings; melting; metabolic abnormality assessment; neuronal; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathway; physical property; programs; public health relevance; receptor; small molecule; social disturbance; ventral tegmentum",Design and Synthesis of New Neuronal nAChR Silent Desensitizers for Drug Abuse,"  Program Director/Principal Investigator (Last, First, Middle): Paige, Mikell  Drug addiction is a chronic brain disease with devastating societal impact. Since drug addiction has traditionally been viewed as a social problem, not a health problem, there is a disparity in effective medical treatment options. This proposal is directed at addressing this disparity by providing new therapeutic agents for medical intervention of drug abuse. PHS 398/2590 (Rev. 11/07) Page 1 Continuation Format Page",25947,ZRG1,Special Emphasis Panel,,2,232506,
7768413,R03,DA,5,,02/01/2010,01/31/2011,PAS-07-327,5R03DA025948-02,,NIDA:181294;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LEXINGTON,UNITED STATES,PHARMACOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"ZHENG, GUANGRONG ;",9212459;,5R03DA025948,02/15/2009,01/31/2011,"2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-; 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Addiction, Drug; Addiction, Opiate; Affinity; Assay; Behavioral; Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Bioniche Brand of Carbachol; CHO Cells; Carbachol; Carbacholine; Carbocholine; Carboxylic Acids; Cells; Chemical Dependence; Chinese Hamster; Chinese Hamster Ovary Cell; Clinical Research; Clinical Study; Cocaine; Common Rat Strains; Contin, MS; Corpus Striatum; Corpus striatum structure; DA Neuron; Dependence, Drug; Dependence, Opiate; Development; Diacetylmorphine; Diamorphine; Dopamine; Dopamine neuron; Drug Addiction; Drug Dependency; Drug Metabolic Detoxication; Drug abuse; Effectiveness; Esters; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Evaluation; Exhibits; Goals; Hamster, Chinese; Heroin; Human; Human, General; Hydrolysis; Hydroxytyramine; Hyoscine; Individual; Infumorph; Inositide Phospholipids; Inositol Phosphoglycerides; Inositol Phospholipids; Kadian; Ligands; Literature; M1 receptor; MSir; Macaca mulatta; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mediating; Medical; Membrane; Metabolic Detoxication, Drug; Metabolic Detoxification, Drug; Metabolic Drug Detoxications; Metabolism of Toxic Agents; Mice; Modification; Molecular Interaction; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphine; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinic M1 Receptor; Muscle Rigidity; Nucleus Accumbens; NutraMax Brand of Carbachol; Opiate Addiction; Oramorph; Oramorph SR; Ovarian; Oxotremorine; Pathway interactions; Phosphatidyl Inositol; Phosphatidylinositols; Phosphoinositides; Physiologic; Physiological; PtdIns; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Receptor Inhibition; Receptor Protein; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinants; Reporting; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rewards; Rhesus; Rhesus Macaque; Rhesus Monkey; Rigidity; Rigidity, Muscular; Role; Roxanol; Scopolamine; Self Administration; Slice; Statex SR; Striate Body; Striatum; Substantia Nigra; Substantia nigra structure; Testing; Ventral Tegmental Area; Withdrawal; abuse of drugs; abused drugs; abuses drugs; analog; base; compound-1; design; designing; detoxification; dopaminergic neuron; drug of abuse; drugs abused; drugs of abuse; membrane structure; novel; opioid addiction; opioid dependence; pars compacta; pathway; pharmacophore; public health relevance; receptor; receptor binding; receptor function; response; scaffold; scaffolding; social role; striatal; tool; ventral tegmentum",Development of Antagonists for M5 Muscarinic Acetylcholine Receptor, These studies will pioneer the development of selective M5 receptor antagonists which have potential as efficacious treatments for drugs of abuse.,25948,ZRG1,Special Emphasis Panel,,2,181294,
7776977,R03,DA,5,,02/01/2010,01/31/2011,DA-08-017,5R03DA026030-02,,NIDA:148064;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEWARK,UNITED STATES,PHARMACOLOGY,10,623946217,US,NJ,07107,UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL,"KUZHIKANDATHIL, ELDO V;",6093056;,5R03DA026030,03/01/2009,01/31/2011,"3' Untranslated Regions; 3'UTR; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Addiction, Cocaine; Addiction, Drug; Addictive Behavior; Address; Age; Ammon Horn; Animals; Applied Research; Applied Science; Area; Assay; Atlases; BDNF; Basic Research; Basic Science; Behavior; Behavioral; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Biology; Brain; Brain region; Brain-Derived Neurotrophic Factor; Cell Line; Cell Lines, Strains; CellLine; Cells; Chemical Dependence; Chimera Protein; Chimeric Proteins; Chronic; Cocaine; Cocaine Dependences; Combining Site; Consensus; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; D1 receptor; DRD1; DRD1 gene; Dependence, Drug; Dependences, Cocaine; Development; Dopamine; Dopamine D1 Receptor; Dopamine Receptor; Dopamine Receptor D1 Gene; Drug Addiction; Drug Dependency; Dysfunction; Encephalon; Encephalons; Exhibits; Functional disorder; Fusion Protein; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; General Population; General Public; Genes; Genes, Reporter; Goals; Hippocampus; Hippocampus (Brain); Hydroxytyramine; In Vitro; Injection of therapeutic agent; Injections; Knockout Mice; Lead; MGC34632; Mammals, Mice; Mammals, Rodents; Mediating; Messenger RNA; Methods; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Micro RNA; MicroRNAs; Molecular; Molecular Interaction; Murine; Mus; NRVS-SYS; National Institute of Neurological Disorders and Stroke; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurotransmitters; Nucleus Accumbens; Null Mouse; Pathway interactions; Pb element; Physiopathology; Play; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA, Messenger; Reactive Site; Receptor Gene; Receptor Protein; Regulation; Reporter; Reporter Genes; Reporting; Research; Rodent; Rodentia; Rodentias; Role; Self Administration; Striate Body; Striatum; System; System, LOINC Axis 4; Testing; Transgenes; Transgenic Mice; Translational Research; Translational Research Enterprise; Translational Science; Translations; Ventral Tegmental Area; cis acting element; cultured cell line; experience; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hippocampal; improved; mRNA; mRNA Expression; miRNA; neuronal; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathophysiology; pathway; prevent; preventing; protein expression; public health relevance; receptor; receptor expression; research study; reward processing; social role; striatal; translation research enterprise; ventral tegmentum",Regulation of D1 Dopamine Receptor Expression by ncRNA in Cocaine Addiction, The goal of this proposal is to determine the role of microRNAs in mediating regulation of D1 dopamine receptor expression in cocaine addiction. The project will identify the microRNA that is involved and demonstrate how it mediates the post-transcriptional regulation of D1 receptor expression in cocaine- treated animals. The results of this proposal will open a new area of research in dopamine receptor biology and lead to the development of potentially novel therapeutic methods for treating cocaine addiction.,26030,ZDA1,Special Emphasis Panel,,2,148064,
7787099,R03,DA,5,,01/01/2010,12/31/2010,PA-07-349,5R03DA026721-02,,NIDA:142560;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,COLUMBIA,UNITED STATES,PSYCHOLOGY,06,111310249,US,SC,29208,UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA,"ZHU, JUN ;",8842226;,5R03DA026721,04/01/2009,12/31/2010,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AIDS; AIDS Dementia; AIDS Dementia Complex; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS with dementia; AIDS-related dementia; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immune Deficiency Syndrome related dementia; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Animal Experiments; Anti-HIV Positivity; Assay; Attenuated; Behavior; Behavioral; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Brain; CDC; Cardiovascular Diseases; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of smoking; Cocaine; Common Rat Strains; Corpus Striatum; Corpus striatum structure; DAT; DAT dopamine transporter; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Dependence, Nicotine; Depression; Development; Dopamine; Dose; Dysfunction; Encephalon; Encephalons; Experiments, Animal; Exposure to; Functional disorder; Gene Transcription; Genetic Transcription; Goals; HIV; HIV Antibody Positivity; HIV Dementia; HIV Infections; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV associated dementia; HIV-1; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-I; HIV-related dementia; HIV1; HTLV-III; HTLV-III Infections; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-III-LAV Infections; Hazards, Health; Health Hazards; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; Hydroxytyramine; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Impairment; In Vitro; Individual; Infection; Infection-Related Malignancy; Infection-Related Malignant Neoplasm; Infusion; Infusion procedures; Intravenous; LAV-HTLV-III; Locomotor Activity; Lymphadenopathy-Associated Virus; Mammals, Rats; Man (Taxonomy); Man, Modern; Measurement; Mediating; Mental Depression; Microinjections; Molecular Interaction; Motor Activity; Nervous; Nervous System, Brain; Neurobiology; Neurochemistry; Neurologic; Neurological; Nicotine; Nicotine Dependence; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nucleus Accumbens; Pathogenesis; Physiopathology; Play; Population; Programs (PT); Programs [Publication Type]; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; RNA Expression; Rat; Rattus; Research; Research Proposals; Risk; Role; Science of neurochemistry; Side; Smoke; Smoker; Striate Body; Striatum; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; TAT; Testing; Time; Tobacco; Tobacco smoking; Trans-Acting Factors; Trans-Activation of Transcription Protein; Trans-Activator of Transcription of HIV; Trans-Activators; Transactivating Regulatory Protein; Transactivators; Transcription; Transcription, Genetic; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Ventral Tegmental Area; Viral; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus-HIV; Work; antibody positive AIDS test; antigen positive AIDS test; cardiovascular disorder; cease smoking; density; design; designing; dopamine system; dopamine transporter; dopamine transporter proteins; experience; experiment; experimental research; experimental study; human T cell leukemia virus III; human T lymphotropic virus III; in vivo; infection related cancer; insight; mesolimbic system; neural; neurobehavioral; neurobiological; neurobiological mechanism; neurochemistry; neuron toxicity; neuronal toxicity; neurotoxicity; nicotine addiction; nicotine craving; pathophysiology; programs; public health relevance; relating to nervous system; research study; response; seropositive (AIDS test); smoking cessation; smoking prevalence; social role; striatal; tat Protein; trans acting factor (genetic); ventral tegmentum; virus protein",Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization, Project Narrative These results will provide new insights into the underlying neurobehavioral mechanisms through which HIV- positive individuals show increased vulnerability to NIC dependence. Understanding this mechanism will have the potential to facilitate the development of effective smoking cessation programs in HIV-positive population.,26721,ZRG1,Special Emphasis Panel,,2,142560,
7776908,R03,DA,5,,03/01/2010,02/28/2011,PA-07-308,5R03DA026725-02,,NIDA:82113;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"ZULE, WILLIAM A;",3058340;,5R03DA026725,03/01/2009,02/28/2011,"AIDS Virus; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Asia; Belief; Blood; China; Cities; Country; Data; Drug abuse; Eastern Europe; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Europe; Europe, Eastern; General Population; General Public; HCV infection; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; High-Risk Sex; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Incidence Study; India; Individual; Infection; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; Intervention; Intervention Strategies; Investigators; Investments; Knowledge; LAV-HTLV-III; Lead; Link; Low Prevalence; Lymphadenopathy-Associated Virus; Mainland China; Math Models; Modeling; NANBH; Needle Sharing; Needlesharing; One Step; One-Step dentin bonding system; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pb element; Play; Population; Prevalence; Process; Recording of previous events; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Risk; Role; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Sexual Transmission; Site; Study, Incidence; Syringe Sharing; Syringes; T-Lymphotropic Virus Type III Infections, Human; Testing; Time; Transmission; Transmission, Sexual; Unprotected Sex; Unsafe Sex; Virus; Virus-HIV; Viruses, General; abuse of drugs; abuses drugs; comparison group; experience; heavy metal Pb; heavy metal lead; hepatitis non A non B; hepatitis nonA nonB; high risk; interventional strategy; mathematical model; mathematical modeling; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; novel; premature; public health relevance; social role; transmission process",The Role of Dead Space Syringes in HIV Epidemics Amount IDU's - Drug Abuse Aspect," PROJECT NARRATIVE The information obtained in this project may substantially increase our knowledge of HIV transmission among injecting drug users (IDUs). If we find that the types of syringes used by IDUs influence HIV transmission, this could lead to relatively straightforward interventions that could substantially reduce HIV transmission in this high risk group. This in turn could reduce sexual transmission of HIV from IDUs to the general population.",26725,BSPH,Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section,,2,82113,
7771702,R03,DA,5,,02/01/2010,01/31/2011,PA-07-349,5R03DA026731-02,,NIDA:133650;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CARSON,UNITED STATES,SOCIAL SCIENCES,37,103895579,US,CA,90747,CALIFORNIA STATE UNIV-DOMINGUEZ HILLS,"MUTCHLER, MATT GARY;",9599648;,5R03DA026731,02/15/2009,01/31/2011,"21 year old; AIDS; AIDS Virus; AOD use; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; African; African American; Afro American; Afroamerican; Alcohol Drinking; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Black Populations; Black or African American; Chemical Class, Alcohol; County; Crystal Meth; Data; Deoxyephedrine; Desoxyephedrine; Diaries; Diaries (PT); Diaries [Publication Type]; Drug usage; Drugs; EtOH drinking; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; High-Risk Sex; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Interview; Investigation; Investigators; LAV-HTLV-III; Latino; Lead; Life; Los Angeles; Lymphadenopathy-Associated Virus; Marihuana; Medication; Mental Health; Mental Hygiene; Methamphetamine; Method LOINC Axis 6; Methodology; Methods; Methylamphetamine; N-Methylamphetamine; Participant; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Play; Population; Preventive Intervention; Psychological Health; Recruitment Activity; Reporting; Research; Research Personnel; Researchers; Risk; Risk Behaviors; Risky Behavior; Sampling; Sex Behavior; Sexual Activity; Sexual Behavior; Stigmata; Substance abuse problem; Survey Instrument; Surveys; T-Lymphotropic Virus Type III Infections, Human; Target Populations; Training; Unprotected Sex; Unsafe Sex; Virus-HIV; Work; abuse of substances; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; at risk behavior; base; black American; diaries; drug use; drug/agent; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; heavy metal Pb; heavy metal lead; high risk; information gathering; insight; member; men; men who have sex with men; men who have sex with other men; men's; novel; peer; preventional intervention strategy; public health relevance; recruit; sex; sex activity; sex risk; social stigma; stem; stigma; substance abuse; substance abuse prevention; substance use; theories; twenty-one year old",Sex-drugs and HIV: How substances became associated with sex among African Americ," Narrative African American and Latino young men who have sex with men (YMSM) are at particularly high risk of HIV infection. Though the risks associated with these 'sex-drug' connections have been extensively studied in some MSM populations, they have been largely unexplored among African American and Latino YMSM. The study data can be used to inform HIV and substance abuse prevention interventions targeting these specific populations, ultimately, helping to reduce HIV infections among African American and Latino YMSM.",26731,ZRG1,Special Emphasis Panel,,2,133650,
7758727,R03,DC,5,,02/01/2010,01/31/2011,PAR-07-287,5R03DC009050-03,,NIDCD:105064;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,SAN ANTONIO,UNITED STATES,BIOLOGY,23,800189185,US,TX,782490600,UNIVERSITY OF TEXAS SAN ANTONIO,"RATNAM, RAMA ;",8367627;,5R03DC009050,02/15/2008,01/31/2011,"ARO; ARO1; Accounting; Acoustic; Acoustics; Address; Age Group Unspecified; Anesthesia; Anesthesia procedures; Animal Welfare; Animals; Auditory; Bibliography; Biological Models; Budgets; CPV1; CYAR; CYP19; CYP19A1; CYP19A1 gene; Callithrix; Callithrix jacchus; Callithrix jacchus jacchus; Confidence Intervals; Contralateral; Country; Critiques; Data; Disease; Disorder; Ear; Ear structure; Ecological impact; Electrophysiology; Electrophysiology (science); Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Experimental Designs; Frequencies (time pattern); Frequency; Goals; Hapale; Hearing; Hearing Loss; Hour; Human; Human, General; Hypoacuses; Hypoacusis; IACUC; IRBs; Impact, Environmental; Implant; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigation; Longitudinal Studies; Man (Taxonomy); Man, Modern; Marmoset, Common; Marmoset, Short-Tusked; Marmosets; Measurement; Measures; Mentors; Methods; Methods and Techniques; Methods, Other; Minor; Model System; Models, Biologic; Neurophysiology / Electrophysiology; Noise; Otoacoustic Emissions, Spontaneous; P-450AROM; Physiology; Posters; Posters [Publication Type]; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; Reflex; Reflex action; Reproducibility; Research; Research Design; Research Ethics Committees; Research Resources; Resources; SCHED; Sample Size; Schedule; Specific qualifier value; Specified; Spontaneous Otoacoustic Emissions; Study Type; Techniques; Testing; Tympanometry; Vertebrate Animals; Vertebrates; Work; Writing; abstracting; acoustic reflex; age dependent; age effect; age group; age related; aging effect; aural muscle; austin; base; disease/disorder; ear muscle; experience; expiration; hearing impairment; hearing perception; human subject; long-term study; meetings; middle ear; neural mechanism; neuromechanism; otoacoustic emission; posters; programs; sound perception; study design; vertebrata",Effects of aging on evoked otoacoustic emissions in the common marmoset,,9050,ZDC1,Special Emphasis Panel,,3,105064,
7798017,R03,DC,5,,03/01/2010,02/28/2011,PAR-07-287,5R03DC009055-02,,NIDCD:150257;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ANN ARBOR,UNITED STATES,BIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"LIU, HONGXIANG ;",8796847;,5R03DC009055,03/31/2009,02/29/2012,"0-6 weeks old; Afferent Neurons; Apical; Appearance; Area; Attention; Biology; Blastocytes; Blastomeres; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Growth and Maintenance; Cell Lineage; Cell Maintenance; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Common Rat Strains; Culturing, in vitro Organ; Culturing, in vitro Vertebrate, Organ; Data; Derivation; Derivation procedure; Development; Embryo; Embryonic; Embryonic Cell; Epithelial Cells; Epithelium; Esthesia; Event; Feeding behaviors; Fiber; Foundations; Fungiform Papilla; Future; Ganglia, Sensory; Genes, LacZ; Goals; Grant; Gustation; Housing; IHC; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; In element; Indium; Infant, Newborn; Ingestive Behavior; Intracellular Communication and Signaling; Knowledge; Label; Laboratories; LacZ; LacZ Genes; Life; Location; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Mesenchymas; Mesenchyme; Mice; Mice, Transgenic; Murine; Mus; Nature; Nerve Cells; Nerve Unit; Nervous; Neural Cell; Neural Crest; Neural Crest Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Newborn Infant; Newborns; Organ; Organ Culture; Organ Culture Techniques; Papilla of tongue; Peripheral; Phenotype; Publishing; QOL; Quality of life; Rat; Rattus; Reporter; Rodent; Rodentia; Rodentias; Sensation; Sensory; Sensory Cell Afferent Neuron; Sensory Ganglia; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stimulus; Structure of blastomere; System; System, LOINC Axis 4; Taste; Taste Bud Cell; Taste Buds; Taste Perception; Time; Tongue; Transgenes; Transgenic Mice; Tubulin; Vertebrate Animals; Vertebrates; base; biological signal transduction; blastomere structure; cell type; density; experiment; experimental research; experimental study; feeding-related behaviors; immunoreaction; insight; neural; neuronal; newborn human (0-6 weeks); nutrient intake activity; papilla; postnatal; precursor cell; public health relevance; relating to nervous system; research study; tongue papilla; vertebrata",Differentiation of taste papilla epithelium during development," Project Narrative The sense of taste informs our nutritive choices, which are essential for life and quality of life. Knowledge of taste papilla development will contribute to understanding how the distribution and density of tongue taste organs are determined, and therefore, to understanding how taste sensitivity emerges.",9055,ZDC1,Special Emphasis Panel,,2,150257,
7763227,R03,DC,5,,02/01/2010,01/31/2011,PAR-07-287,5R03DC009488-02,,NIDCD:151965;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,NASHVILLE,UNITED STATES,OTOLARYNGOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"POLLEY, DANIEL B.;",8973550;,5R03DC009488,02/15/2009,01/31/2012,"Acoustic; Acoustics; Action Potentials; Animals; Auditory; Auditory system; Behavior; Behavioral; Behavioral Assay; Biochemistry; Biophysics; Brain; Brain Stem; Brainstem; Cell Nucleus; Cell membrane; Cells; Characteristics; Chemistry, Biological; Cognitive Discrimination; Cytoplasmic Membrane; DNA Alteration; DNA mutation; Detection; Discrimination; Discrimination (Psychology); Encephalon; Encephalons; Exhibits; Face; Frequencies (time pattern); Frequency; Gene Alteration; Gene Deletion; Gene Mutation; Generations; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetic mutation; Genotype; Goals; Grant; Hearing; Impairment; In Vitro; Inferior Colliculus; K element; Knock-out; Knockout; Knockout Mice; Light; Mammals, Mice; Measurement; Measures; Membrane Potentials; Mesencephalon; Mice; Mice, Knock-out; Mice, Knockout; Mid-brain; Midbrain; Midbrain structure; Molecular; Murine; Mus; Mutation; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Nucleus; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Pattern; Perception; Phenotype; Photoradiation; Physiologic; Physiological; Plasma Membrane; Play; Posterior Quadrigeminal Body; Potassium; Probability; Process; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Rest; Resting Potentials; Role; Science of neurophysiology; Sequence Alteration; Series; Shapes; Sound; Sound - physical agent; Specificity; Stimulus; Structure; Surgical; Surgical Interventions; Surgical Procedure; Testing; Transmembrane Potentials; V (voltage); Variant; Variation; Wild Type Mouse; Work; audiogenic seizure; auditory stimulus; awake; behavioral impairment; computerized data processing; data processing; experiment; experimental research; experimental study; facial; gene deletion mutation; genome mutation; hearing perception; improved; information processing; neuronal; neuronal excitability; neurophysiology; plasmalemma; receptive field; research study; response; signal processing; social role; sound; sound frequency; sound perception; surgery; voltage",The Auditory Phenotype of Kv Channel Gene Mutations," NARRATIVE  These experiments will further our understanding of the molecular determinants of brain function and behavior. By studying the effects of single gene deletions on the physiological response properties of single cells in the brain and the hearing abilities of animals actively engaged in listening tasks, the proposed experiments may allow us to frame the effects of genetic mutations in a more integrative context of auditory system function. Furthermore, the proposed experiments could shed additional light on the role of intrinsic neuronal excitability in the context of auditory information processing as well as pathological states such as audiogenic seizure.",9488,ZDC1,Special Emphasis Panel,,2,151965,
7764659,R03,DC,5,,02/01/2010,01/31/2011,PAR-07-287,5R03DC009853-02,,NIDCD:148500;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,HOUSTON,UNITED STATES,NEUROSCIENCES,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"FLETCHER, MAX L;",7257014;,5R03DC009853,02/02/2009,01/31/2012,"21+ years old; Address; Adult; Affect; Aldehydes; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Animals; Associative Learning; Behavior; Behavioral; Biological Models; Blood Coagulation Factor IV; Ca++ element; Calcium; Cells; Central Nervous System; Coagulation Factor IV; Code; Coding System; Conditioning, Classical; Conditionings, Classical; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Diagnosis; Disease; Disorder; Dorsal; Dysfunction; Factor IV; Food; Functional disorder; Goals; Grant; Human; Human, Adult; Human, General; Idiopathic Parkinson Disease; Image; Individual; Learning; Lewy Body Parkinson Disease; Life; Mammalia; Mammals; Mammals, General; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maps; Memory; Mice; Mice, Transgenic; Model System; Models, Biologic; Murine; Mus; Neocortex; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Odors; Olfaction; Olfactions; Olfactory Bulb; Olfactory Learning; Olfactory Pathways; Output; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Pattern; Pavlovian conditioning; Perception; Physiopathology; Play; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Receptor Protein; Reproduction; Rodent; Rodentia; Rodentias; Role; Schizophrenia; Schizophrenic Disorders; Sensory; Sensory Process; Series; Shapes; Site; Smell; Smell Perception; Source; Staging; Stimulus; Structure of olfactory bulb; Surface; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Time; Training; Transgenic Mice; adult human (21+); aversive conditioning; base; calcium indicator; classical conditioning; conditioning; dementia of the Alzheimer type; dementia praecox; disease/disorder; experience; homotypical cortex; imaging; imaging modality; imprint; in vivo; interest; isocortex; mouse model; neopallium; nervous system disorder; neural; neural circuit; neural circuitry; neurological disease; neuronal; novel; olfactory bulb; optic imaging; optical imaging; pathophysiology; pathway; perceptual stimulus; physicochemical phenomena related to the senses; postsynaptic; primary degenerative dementia; public health relevance; receptive field; receptor; relating to nervous system; response; schizophrenic; senile dementia of the Alzheimer type; sensor; sensory cortex; sensory stimulus; sensory system; social; social role",In vivo optical imaging of experience-induced olfactory bulb glomerular plasticit," Project Narrative  The sense of smell plays an important role in our daily life. Olfaction dysfunction is often times an early indicator of several major neurological diseases in humans including Alzheimer's disease, Parkinson's disease, and schizophrenia. The general goal of this grant is to understand the neural basis of olfactory processing which could help in the diagnosis and treatment of these diseases.",9853,ZDC1,Special Emphasis Panel,,2,148500,
7763260,R03,ES,5,,02/01/2010,01/31/2011,PA-06-180,5R03ES016606-02,,NIEHS:76230;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,ROCHESTER,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"GASIEWICZ, THOMAS A;",1863150;,5R03ES016606,02/01/2009,01/31/2011,"AHR; Actions, Chemical; Activities of Daily Living; Activities of everyday life; Address; Adolescent; Adolescent Youth; Age; Aging Process; Aging-Related Process; Alleles; Allelomorphs; Animals; Aromatic Polycyclic Hydrocarbons; Aryl Hydrocarbon Receptor; Autoimmune Diseases; Binding; Binding (Molecular Function); Blood (Leukemia); Blood Cells; Blood Precursor Cell; Bone Marrow; Bone Marrow Transplant; Bone Marrow Transplantation; Bone marrow failure; Cancer Treatment; Cancers; Cell Cycle; Cell Division Cycle; Cell Lineage; Cells; Characteristics; Chemical Actions; Clinical; Cytofluorometry, Flow; Data; Development; Dioxin Compound; Dioxins; Disease; Disorder; Equilibrium; Event; Exhibits; Exposure to; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Genes; Grafting, Bone Marrow; Hematopoiesis; Hematopoietic; Hematopoietic Cellular Control Mechanisms; Hematopoietic stem cells; Human; Human, General; Hydrocarbons; Incidence; Kinetic; Kinetics; Leukemias, General; Link; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Transplantation; Mediating; Mice; Microfluorometry, Flow; Modeling; Molecular Interaction; Mother Cells; Murine; Mus; Nuclear Translocator; PAH; Pancytopenia; Peripheral Blood Cell; Physiologic; Physiological; Play; Polycyclic Hydrocarbons, Aromatic; Polynuclear Aromatic Hydrocarbons; Population; Prevention; Process; Progenitor Cells; Progenitor Cells, Hematopoietic; Receptor Activation; Receptor Protein; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Receptors, AH; Receptors, Dioxin; Receptors, Polyaromatic Hydrocarbon; Regulation; Regulatory Protein; Reticuloendothelial System, Bone Marrow; Role; Specificity; Stem cells; Stress; TCDD Receptors; Testing; Transplantation; ahr ligand; anticancer therapy; aryl hydrocarbon receptor ligand; autoimmune disorder; balance; balance function; cancer therapy; daily living functionality; dioxin receptor, nuclear translocator; disease/disorder; exposed human population; flow cytophotometry; functional ability; functional capacity; genetic regulatory protein; human exposure; in vivo; juvenile; juvenile human; leukemia; leukemia/lymphoma; lymphoma/leukemia; malignancy; mouse model; neoplasm/cancer; polynuclear aromatic hydrocarbon; public health relevance; receptor; reconstitute; reconstitution; regenerative; regulatory gene product; self-renewal; social role; stem; transcription factor; transplant",A Role of the Ah Receptor in Hematopoiesis: Model Characterization," RELEVANCE TO HUMAN HEALTH The further understanding of the processes regulating HSC self-renewal and differentiation are fundamental to the prevention and treatment of a variety of leukemias and other hematopoietic diseases in humans. Understanding what regulates the normally incredible regenerative capacity of bone marrow also has clinical implications for bone marrow transplantation, autoimmune disease, and bone marrow failure that may be associated with cancer treatment. Furthermore, these events are intimately tied with the process of aging and a variety of diseases, including cancer, whose incidence increases with age.",16606,HP,Hematopoiesis Study Section,,2,76230,
7765530,R03,NS,5,,02/01/2010,01/31/2011,PA-06-180,5R03NS065299-02,,NINDS:70538;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOZEMAN,UNITED STATES,ANATOMY/CELL BIOLOGY,00,625447982,US,MT,59717,MONTANA STATE UNIVERSITY (BOZEMAN),"LEFCORT, FRANCES ;",1879583;,5R03NS065299,02/15/2009,01/31/2011,"21+ years old; ALK protein; ALS; Adult; Amyotrophic Lateral Sclerosis; Anaplastic Lymphoma Kinase Ki-1; Apoptosis; Apoptosis Pathway; Aran-Duchenne disease; Basic Research; Basic Science; CD246 Antigen; Cause of Death; Cell Death, Programmed; Chick Embryo; Clinical; Communities; Cruveilhier disease; Data; Development; Disease; Disorder; Ectopic Expression; Funding; Gehrig's Disease; Goals; Grant; Human, Adult; Lead; Lou Gehrig Disease; Medulla Spinalis; Motor Cell; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neurons; Myelopathy, Traumatic; Nervous; Neurosciences; Onset of illness; PTK Receptors; Palsy; Paralysed; Pathway interactions; Pattern; Pb element; Peripheral Nervous System; Plegia; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Programs (PT); Programs [Publication Type]; Proteins; Quelling; R01 Mechanism; R01 Program; RNA Interference; RNA Silencing; RNA Silencings; RNAi; RPG; RTK; Receptor Protein-Tyrosine Kinases; Regulation; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Role; Sequence-Specific Posttranscriptional Gene Silencing; Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Muscular Atrophy; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Testing; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Work; adult human (21+); anaplastic lymphoma kinase; apoptosis of neuronal cells; base; developmental disease/disorder; developmental disorder; disease onset; disease/disorder; disorder onset; gene product; heavy metal Pb; heavy metal lead; in vivo; knock-down; loss of function; meetings; motoneuron; neural; neuron apoptosis; neuronal apoptosis; neurotrophic factor; neurotrophin; neutrophin; new therapeutics; next generation therapeutics; novel; novel therapeutics; paralysis; paralytic; pathway; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons; programs; public health relevance; relating to nervous system; social role",The role of Anaplastic Lymphoma Kinase in motor neuron survival," Project Narrative If spinal motor neurons die, paralysis results. Motor neurons die in developmental disorders such as Spinal Muscular Atrophy and in adult-onset disorders such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and following spinal cord injury. We have identified a protein, Anaplastic lymphoma kinase, which is expressed on spinal motor neurons. Our preliminary data indicates that reducing levels of this protein causes the death of spinal motor neurons. The goal of this study is to increase levels of this protein to test whether we can rescue dying spinal motor neurons. This work could lead to novel therapeutics for promoting the survival of motor neurons in neural disease.",65299,NOMD,Neural Oxidative Metabolism and Death Study Section,,2,70538,
7758288,R03,TW,5,,01/01/2010,12/31/2010,PAR-06-436,5R03TW007220-03,,FIC:39738;,2010,FOGARTY INTERNATIONAL CENTER,,GREAT FALLS,UNITED STATES,,00,619471691,US,MT,594054900,MC LAUGHLIN RESEARCH INSTITUTE,"MERCER, JOHN A;",1882389;,5R03TW007220,01/01/2008,12/31/2010,"Address; Animal Welfare; Bibliography; Country; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Hand; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; MYH12 protein, human; MYO5A protein; MYO5A protein, human; Mammals, Mice; Mice; Mice, Transgenic; Murine; Mus; Peptide Biosynthesis, Ribosomal; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Research; Research Ethics Committees; Research Resources; Resources; Transgenic Mice; Uruguay; Vertebrate Animals; Vertebrates; abstracting; dilute protein; expiration; human MYO5A protein; human subject; myosin VA (heavy polypeptide 12, myoxin) protein, human; myosin Va; myoxin; programs; protein synthesis; tool; vertebrata",Myosin-Va and axonal protein synthesis,,7220,ICP1,International and Cooperative Projects - 1 Study Section,,3,39738,
7753219,R03,TW,5,,01/01/2010,12/31/2010,PAR-06-436,5R03TW007446-03,,FIC:26254;,2010,FOGARTY INTERNATIONAL CENTER,,GAINESVILLE,UNITED STATES,MISCELLANEOUS,06,969663814,US,FL,326115500,UNIVERSITY OF FLORIDA,"LOUNIBOS, LEON PHILIP;",1960285;,5R03TW007446,01/01/2008,12/31/2010,"21+ years old; Active Follow-up; Adult; Aedes; Aedes (genus); Affect; Animal Welfare; Arboviruses; Area; Arthropod-Borne Viruses; Behavior; Behavioral; Bibliography; Biology; Blood; Blood Glucose; Blood Sugar; Body Size; Brazil; Censuses; Communities; Complex; Country; Culex pipiens; Culex pipiens mosquito; Culicidae; Data; Dengue; Dengue Fever; Development; Diet; Ecological impact; Ecology; Environment; Environmental Impact; Environmental Science; Equilibrium; Equipment; Ethics Committees, Research; Evolution; Feeds; Female; Florida; Fostering; Frequencies (time pattern); Frequency; Funding; Habitats; Human, Adult; IACUC; IRBs; Impact, Environmental; Infection; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Investigators; Laboratories; Length; Link; Measures; Methods; Modeling; Mosquitoes; Outcome; Population; Population Density; Predatory Behavior; Predisposition; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Public Health; Publications; Relative; Relative (related person); Research; Research Ethics Committees; Research Personnel; Research Resources; Research Specimen; Researchers; Resources; Reticuloendothelial System, Blood; Role; Scientific Publication; Series; Shapes; Sindbis Virus; Site; Specimen; Staging; Stress; Structure; Students; Susceptibility; Temperature; Testing; Time; Transmission; Variant; Variation; Vertebrate Animals; Vertebrates; Wing; Work; abstracting; adult human (21+); balance; balance function; base; breakbone fever; density; egg; emerging adult; experiment; experimental research; experimental study; expiration; feeding; follow-up; geographic difference; geographic variation; human population density; human subject; life history; parent grant; predation; programs; public health medicine (field); research study; social role; sugar; survivorship; transmission process; vector; vertebrata",Invasive Aedes Mosquitoes and Dengue in Brazil,,7446,ICP1,International and Cooperative Projects - 1 Study Section,,3,26254,
7753217,R03,TW,5,,01/01/2010,12/31/2010,PAR-06-436,5R03TW007754-03,,FIC:31798;,2010,FOGARTY INTERNATIONAL CENTER,,OAKLAND,UNITED STATES,,09,076536184,US,CA,94609,CHILDREN'S HOSPITAL & RES CTR AT OAKLAND,"DEAN, DEBORAH ANNE;",1888144;,5R03TW007754,01/01/2008,12/31/2010,"AIDS Virus; Abbreviations; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adolescent; Adolescent Youth; Amino Acid Sequence Homology; Amino Acids; Anabolism; Animal Welfare; Antigen Variation; Antigenic Variability; Antigenic Variation; Assay; Bacterial Vaginosis; Bibliography; Bioassay; Biologic Assays; Biological Assay; Biosynthetic Proteins; Blood Serum; C. pneumoniae; C. psittaci; C.pneumoniae; C.psittaci; Cannot achieve a pregnancy; Care, Health; Cervical; Chlamydia; Chlamydia pneumoniae; Chlamydia psittaci; Chlamydia trachomatis; Chlamydiales; Chlamydophila pneumoniae; Chlamydophila psittaci; Clinic; Clinical; Collaborations; Commit; Communicable Diseases; Confidence Intervals; Country; DNA; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Developing Countries; Developing Nations; Difficulty conceiving; Dioxygenases; Disease; Disorder; Dot Immunoblotting; Ecological impact; Ectopic Pregnancy; Ecuador; Educational process of instructing; Enrollment; Environment; Environmental Impact; Enzymes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Equipment; Ethics Committees, Research; Evolution; Exposure to; Expression Profiling; Expression Signature; Eyelash; Faculty; Family; Foundations; Future; Gamma interferon; Gene Proteins; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genome; Genotype; Goals; Gonococcal Infection; Gonorrhea; Grant; HIV; HPV; HTLV-III; Head; Healthcare; Human Immunodeficiency Viruses; Human Papillomavirus; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IACUC; IFN-Gamma; IFN-g; IFNG; INFLM; IRBs; Immunoblotting, Dot; Impact, Environmental; In Vitro; India; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infectious Human Wart Virus; Infertility; Inflammation; Infrastructure; Institution; Institutional Animal Care and Use Committee; Institutional Review Boards; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; International; Intervention; Intervention Strategies; Investigation; Knowledge; L-Serine hydro-lyase (adding indoleglycerol-phosphate); L-Tryptophan; LAV-HTLV-III; Laboratories; Laboratory Research; Lead; Less-Developed Countries; Less-Developed Nations; Levotryptophan; Link; Location; Lymphadenopathy-Associated Virus; MOMP; Medical; Medical Staff; Medical Students; Membrane; Membrane Proteins; Membrane-Associated Proteins; Messenger RNA; Methods and Techniques; Methods, Other; Mexico; Miyagawanella; Molecular Fingerprinting; Molecular Profiling; Mutation; Nepal; Nucleotides; ORFs; Open Reading Frames; Operon; Organism; Papilloma Virus, Human; Papillomavirus, Human; Pathogenesis; Pathology; Patients; Pattern; Pb element; Pelvic Inflammatory Disease; Phenotype; Physicians; Play; Polymorphism (Genetics); Polymorphism, Genetic; Pregnancy, Ectopic; Principal Investigator; Programs (PT); Programs [Publication Type]; Prostitution; Protein Coding Region; Protein Gene Products; Proteins; Publishing; R. psittaci; R.psittaci; RNA, Messenger; RT-PCR; RTPCR; Recombinant Proteins; Recurrence; Recurrent; Research; Research Ethics Committees; Research Infrastructure; Research Proposals; Research Resources; Research Training; Research, Laboratory; Resources; Reverse Transcriptase Polymerase Chain Reaction; Rickettsia psittaci; Rickettsia trachomae; Risk; Role; STD; Sampling; Scientist; Screening procedure; Sequence Homology, Amino Acid; Sequence Homology, Protein; Serologic; Serological; Serotyping; Serum; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Students; Students, Medical; Surface Proteins; TXT; Teaching; Techniques; Text; Third-World Countries; Third-World Nations; Time; Tryptophan; Tryptophan Synthase; Tryptophan Synthetase; Under-Developed Countries; Under-Developed Nations; Vaginitis, Bacterial; Vaginitis, Nonspecific; Variant; Variation; Venereal Diseases; Venereal Disorders; Venereal Infections; Vertebrate Animals; Vertebrates; Viet Nam; Vietnam; Vietnam, Republic of; Virulence; Virus-HIV; Work; abstracting; adult youth; aminoacid; bedsonia; biosynthesis; clinical data repository; clinical data warehouse; commercial sex; commercial sex work; data repository; design; designing; disease/disorder; dot blotting; enroll; experience; expiration; extrauterine pregnancy; gene product; genetic profiling; genome mutation; genome sequencing; graduate student; heavy metal Pb; heavy metal lead; human subject; immunogenic; in vivo; indoleamine; infertile; innovate; innovation; innovative; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; interest; interventional strategy; juvenile; juvenile human; lFN-Gamma; living system; mRNA; major outer membrane protein; member; membrane structure; microbial; molecuar profile; molecular signature; novel; parent grant; patient population; polyclonal antibody; polymorphism; programs; protein expression; prototype; relational database; reverse transcriptase PCR; screening; screenings; sex; social role; success; survival sex; tool; tryptophan desmolase; unable to bear children; vertebrata; wart virus; young adult",Pathogenesis of persistent C. trachomatis STDs,,7754,ICP1,International and Cooperative Projects - 1 Study Section,,3,31798,
7744033,R03,TW,5,,01/01/2010,12/31/2010,PAR-06-436,5R03TW007807-03,,FIC:25380;,2010,FOGARTY INTERNATIONAL CENTER,,INDIANAPOLIS,UNITED STATES,PEDIATRICS,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"TEPPER, ROBERT S.;",1882798;,5R03TW007807,01/01/2008,12/31/2010,"0-11 years old; Abscission; Address; Age; Age-Months; Altitude; Analysis, Data; Animal Welfare; Animals; Appointment; Area; Argentina; BMI percentile; BMI z-score; Bibliography; Birth; Blood Serum; Body Tissues; Body mass index; Child; Child Youth; Children (0-21); Consumption; Country; Country of Argentina; Data; Data Analyses; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; European; Excision; Extirpation; Faculty; Family; Family Physicians; Female; Funding Mechanisms; GFAC; Generalized Growth; Generations; Grant; Growth; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; HOSP; Hospitals; Hospitals, Maternity; Human; Human, Child; Human, General; Hypoxia; Hypoxic; IACUC; IRBs; Impact, Environmental; Indiana; Infant; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Knowledge; Laboratories; Length; Life; Longitudinal Studies; Lung; Man (Taxonomy); Man, Modern; Maternity Hospitals; Measurement; Measures; Metabolic; Neonatology; Nurses; Out-patients; Outpatients; Oxygen Consumption; Oxygen Deficiency; Parents; Parturition; Pattern; Personnel, Nursing; Physicians; Physicians, Family; Population; Population Study; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Quetelet index; Recruitment Activity; Relative; Relative (related person); Removal; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Respiratory System, Lung; Risk; Secondary to; Serum; Site; Study Type; Surgical Removal; Symptoms; Testing; Time Study; Tissue Growth; Tissues; Toddler; Universities; Vertebrate Animals; Vertebrates; Visit; abstracting; awake; children; critical period; design; designing; expiration; human subject; infant measurement; infant monitoring; long-term study; lung volume; male; member; ontogeny; pediatrician; programs; pulmonary; rapid growth; recruit; repair; repaired; resection; respiratory; study design; vertebrata; youngster",Lung Growth in Infants and Toddlers Residing at High Altitude,,7807,ICP1,International and Cooperative Projects - 1 Study Section,,3,25380,
7763232,R03,TW,5,,01/01/2010,12/31/2010,PAR-07-335,5R03TW007815-02,,FIC:30711;,2010,FOGARTY INTERNATIONAL CENTER,,SANTA BARBARA,UNITED STATES,PSYCHOLOGY,23,094878394,US,CA,93106,UNIVERSITY OF CALIFORNIA SANTA BARBARA,"GRAFTON, SCOTT THOMAS;",1870700;,5R03TW007815,02/01/2009,12/31/2011,"0-11 years old; Affect; Algorithms; Apraxia, Ideokinetic; Apraxia, Ideomotor; Apraxia, Limb Kinetic; Apraxia, Transcortical; Area; Argentina; Arm; Ataxia; Ataxy; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Basal Ganglia; Basal Nuclei; Behavior; Brain Mapping; Brain region; Cell Communication and Signaling; Cell Signaling; Cerebellum; Child; Child Youth; Children (0-21); Classic Apraxia; Code; Coding System; Cognitive; Collaborations; Computers; Coordination Impairment; Country of Argentina; Cues; Development; Devices; Disease; Disorder; Dorsal; Dyspraxia, Ideomotor; Dyssynergia; Environment; Face; Feedback; Forearm; Functional Magnetic Resonance Imaging; Future; Generations; Gestures; Goals; Grant; Human; Human, Child; Human, General; Ideomotor Apraxia; Ideomotor Dyspraxias; Intention; Intracellular Communication and Signaling; Investigators; Kanner's Syndrome; Learning; Link; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Mechanics; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods and Techniques; Methods, Other; Modeling; Modification; Motor; Motor Cortex; Movement; Muscle; Muscle Tissue; Musculoskeletal; NIH; NRVS-SYS; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System Injuries; Nervous System Trauma; Nervous System damage; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurological Damage; Neurological Injury; Neurological trauma; Neurons; Noise; Optics; Outcome; Palsy; Paralysed; Parents; Parietal; Parietal Lobe; Parietal Lobe of the Brain; Patients; Perception; Physiology; Plegia; Position; Positioning Attribute; Prefrontal Cortex; Preparation; Principal Investigator; Process; Production; Programs (PT); Programs [Publication Type]; Proprioception; Prosthesis; Prosthetic device; Prosthetics; R01 Mechanism; R01 Program; RPG; Relative; Relative (related person); Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Resistance; Resolution; Role; Rotation; Schizophrenia; Schizophrenic Disorders; Schools, Medical; Science of neurophysiology; Sensory; Short-Term Memory; Sight; Signal Transduction; Signal Transduction Systems; Signaling; System; System, LOINC Axis 4; Techniques; Testing; Time; Training; Transcranial magnetic stimulation; Trauma, Nervous System; United States National Institutes of Health; Universities; Update; Upper arm; Vision; Visual; base; biological signal transduction; blood oxygen level dependent; body movement; children; dementia praecox; design; designing; disease/disorder; experiment; experimental research; experimental study; fMRI; facial; medical schools; motor control; neural; neuronal; neurophysiology; paralysis; paralytic; parent grant; parietal cortex; programs; public health relevance; rehearsal; relating to nervous system; research study; resistant; response; schizophrenic; sensory feedback; skills; social; social role; visual feedback; visual information; visual motor; visuomotor; working memory; youngster",Role of fronto-parietal cortices in the prediction of self-generated and observed,,7815,ICP1,International and Cooperative Projects - 1 Study Section,,2,30711,
7753673,R03,TW,5,,01/01/2010,12/31/2010,PAR-06-436,5R03TW008023-03,,FIC:25380;,2010,FOGARTY INTERNATIONAL CENTER,,HARTFORD,UNITED STATES,,01,077314268,US,CT,061063322,CONNECTICUT CHILDREN'S MEDICAL CENTER,"SALAZAR, JUAN C;",6790598;,5R03TW008023,01/01/2008,12/31/2010,"Animal Welfare; Bibliography; Colombia; Country; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; IACUC; IRBs; Immune response; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Names; Principal Investigator; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Resources; Resources; Syphilis; Vertebrate Animals; Vertebrates; abstracting; expiration; great pox; host response; human subject; immunoresponse; programs; vertebrata",Systemic Innate Immune Responses in Secondary Syphilis,,8023,ICP1,International and Cooperative Projects - 1 Study Section,,3,25380,
7761260,R03,TW,5,,01/01/2010,12/31/2010,PAR-07-335,5R03TW008037-02,,FIC:31925;,2010,FOGARTY INTERNATIONAL CENTER,,SEATTLE,UNITED STATES,BIOLOGY,07,605799469,US,WA,981959472,UNIVERSITY OF WASHINGTON,"DE LA IGLESIA, HORACIO O;",8150551;,5R03TW008037,02/01/2009,12/31/2011,"Accounting; Address; Affect; American; Animals; Area; Argentina; Assay; Authorship; Behavior; Behavioral; Bioassay; Biochemistry; Biologic Assays; Biological Assay; Biological Clocks; Biological Rhythm; Biological Rhythm and Oscillation; Body Temperature; Body Tissues; Books; Brain; Budgets; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cells; Chemicals; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Chronobiology; Circadian Rhythms; Clock, Biologic; Collaborations; Common Rat Strains; Communication; Communities; Complement; Complement Proteins; Country; Country of Argentina; Coupled; Coupling; Cricetinae; DNA Molecular Biology; Darkness; Darknesses; Data; Development; Disease; Disorder; Dissociation; Diurnal Rhythm; Encephalon; Encephalons; Endocrine; Endocrine Gland Secretion; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Equipment; FISH Technic; FISH Technique; FISH analysis; Fluorescent in Situ Hybridization; Funding; Future; Gene Expression; Generations; Genes; Goals; Hamsters; Histocytochemistry; Hormones; Hour; Housing; Human; Human Resources; Human, General; Hypothalamic structure; Hypothalamus; Immunologic, Luciferase; In Situ Hybridization, Fluorescence; In Vitro; Injection of therapeutic agent; Injections; Intention; Intracellular Communication and Signaling; Investigators; Knowledge; Laboratories; Learning; Left; Light; Locomotor Activity; Luciferases; Mammalia; Mammals; Mammals, General; Mammals, Hamsters; Mammals, Rats; Man (Taxonomy); Man, Modern; Manpower; Mediating; Methods and Techniques; Methods, Other; Modeling; Molecular Biology; Monitor; Mononitrogen Monoxide; Motor Activity; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nucleus; Nyctohemeral Rhythm; Operation; Operative Procedures; Operative Surgical Procedures; Output; Pace Stimulators; Pacemakers; Pathology; Pathway interactions; Phase; Photoradiation; Physiologic; Physiologic pulse; Physiological; Physiology; Procedures; Process; Publications; Pulse; Radioactive; Rat; Rattus; Reading; Regulation; Reporting; Research; Research Personnel; Researchers; Role; Running; SCHED; Schedule; Scientific Publication; Screening procedure; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Signaling Molecule; Sleep Stages; Sleep Wake Cycle; Slice; Societies; Stimulators, Electrical, Pace; Stimulus; Structure of suprachiasmatic nucleus; Students; Suprachiasmatic Nucleus; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Testing; Therapeutic Hormone; Time; Tissues; Touch; Touch sensation; Training; Transmission; Travel; Twenty-Four Hour Rhythm; Universities; Visit; Work; base; biological signal transduction; body clock; career; circadian; circadian behavioral rhythms; circadian clock; circadian pacemaker; circadian process; college; conference; daily biorhythm; day shift; disease/disorder; diurnal variation; endothelial cell derived relaxing factor; experience; experiment; experimental research; experimental study; extracellular; graduate student; histochemistry; histochemistry/cytochemistry; hypothalamic; in vivo; insight; intercellular communication; internal clock; light effects; neural; neurobiological; neuronal; night shift; night work; parent grant; pathway; personnel; public health relevance; relating to nervous system; research study; screening; screenings; shift work; social role; success; suprachiasmatic nucleus; surgery; symposium; tool; transmission process",Communication in the Mammalian Circadian Clock: The Role of Nitric Oxide,,8037,ICP1,International and Cooperative Projects - 1 Study Section,,2,31925,
7768400,R03,TW,5,,02/01/2010,01/31/2011,PAR-07-335,5R03TW008039-02,,FIC:37611;,2010,FOGARTY INTERNATIONAL CENTER,,SYRACUSE,UNITED STATES,PHARMACOLOGY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"PERTSOV, ARKADY M;",1889236;,5R03TW008039,02/15/2009,01/31/2012,"3-D Imaging; 3D imaging; Ablation; Absorption; Acute; Address; Advanced Development; Arrhythmia; Arts; Binding; Binding (Molecular Function); Biomedical Engineering; Blood; Boa; Body Tissues; Cardiac; Cardiac Arrhythmia; Cardiac Myocytes; Cardiocyte; Cell membrane; Charge; Clinical; Collaborations; Coloring Agents; Computer Simulation; Computerized Models; Connecticut; Cycloamylose; Cyclodextrins; Cyclomaltooligosaccharides; Cytoplasmic Membrane; Development; Dyes; Electrophysiology; Electrophysiology (science); Elements; Family; Fluorescence; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; General Hospitals; Generations; Goals; Grant; Health; Heart; Heart Arrhythmias; Heart Muscle tissue; Heart myocyte; Hospitals, General; Human; Human, General; Image; Imagery; Imaging Procedures; Imaging Techniques; Imaging technology; Imaging, Three-Dimensional; International; International Cooperation; Knowledge; Lithuania; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Maps; Massachusetts; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Medical; Medical Imaging, Three Dimensional; Membrane; Membrane Potentials; Methods and Techniques; Methods, Other; Models, Computer; Molecular Interaction; Molecular Probes; Muscle Cells, Cardiac; Muscle Cells, Heart; Muscle, Cardiac; Muscle, Heart; Myocardial tissue; Myocardium; Myocytes, Cardiac; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurophysiology / Electrophysiology; Optical Tomography; Optics; Performance; Phototoxicity; Plasma Membrane; Process of absorption; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; RF ablation; Radio Frequency Ablation; Radiofrequency Ablation; Radiofrequency Interstitial Ablation; Research; Resolution; Resting Potentials; Reticuloendothelial System, Blood; Simulation, Computer based; Solid; Speed; Speed (motion); System; System, LOINC Axis 4; Tail; Technics, Imaging; Techniques; Technology; Testing; Three-Dimensional Imaging; Tissues; Tomography, Optical; Toxic effect; Toxicities; Training; Transmembrane Potentials; United States National Institutes of Health; Universities; V (voltage); Visualization; absorption; base; bioengineering; bioengineering/biomedical engineering; cardiac muscle; cardiomyocyte; clinical applicability; clinical application; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; fluorescent dye/probe; heart muscle; human tissue; imaging; in silico; membrane structure; millimeter; new technology; novel; optic imaging; optical imaging; parent grant; plasmalemma; public health relevance; reconstruction; second harmonic; study characteristics; two-photon; virtual simulation; voltage",Development of new NIR probes to study human cardiac excitation,,8039,ICP1,International and Cooperative Projects - 1 Study Section,,2,37611,
7763233,R03,TW,5,,01/01/2010,12/31/2010,PAR-07-335,5R03TW008052-02,,FIC:32486;,2010,FOGARTY INTERNATIONAL CENTER,,MILWAUKEE,UNITED STATES,BIOPHYSICS,05,937639060,US,WI,532260509,MEDICAL COLLEGE OF WISCONSIN,"SUBCZYNSKI, WITOLD K;",6116526;,5R03TW008052,02/01/2009,12/31/2011,"Affect; Age; Aging; Amino Acids; Area; Attention; Biochemistry; Biophysics; Biotechnology; Blindness; Cataract; Cell Membrane Lipids; Cell Membrane Permeability; Cell Nucleus; Cell membrane; Cell surface; Chemistry, Biological; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cognitive Discrimination; Collaborations; Complement; Complement Proteins; Computer Simulation; Computerized Models; Computers; Country of Poland; Crystalline Lens; Cytoplasmic Membrane; Data; Developing Countries; Developing Nations; Development; Diffuse; Diffusion; Discrimination; Discrimination (Psychology); Disease; Disorder; Doctor of Philosophy; EPR spectroscopy; Electron Paramagnetic Resonance; Electron Spin Resonance; Electron Spin Resonance Spectroscopy; Equilibrium; Evaluation; Event; Evolution; Eye; Eyeball; Faculty; Future; GFRP1; Goals; Grant; HMR; Human; Human, General; Hydrocarbons; Investigators; Japan; Knowledge; Lead; Left; Len, Crystalline; Len, Eye; Lens; Lens Cortex, Crystalline; Lens Fiber; Lens of Eye; Lens, Crystalline; Lens, Eye; Lenses; Less-Developed Countries; Less-Developed Nations; Lipid Bilayers; Lipid Rafts, Cell Membrane; Lipids; Liquid substance; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocyte-Specific Protein-Tyrosine Kinase; Lymphocyte-Specific p56LCK Tyrosine Protein Kinase; MGC9485; Mammalian Cell; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Membrane; Membrane Lipids; Membrane Microdomains; Method LOINC Axis 6; Methodology; Methods; Modeling; Models, Computer; Models, Molecular; Mole the mammal; Molecular; Molecular Dynamics Simulation; Molecular Models; Moles; Motion; N-terminal; N10; NAK-1; NAK1; NGFIB; NH2-terminal; NIH; NP10; NR4A1; NR4A1 gene; NUR77; National Institutes of Health; National Institutes of Health (U.S.); Nuclear; Nucleic Acid Biochemistry, Molecular Modeling; Nucleus; O element; O2 element; Ocular Lens; Oxygen; Paper; Paramagnetic Resonance; Pb element; Peer Review; Peptides; Performance; Permeability; Ph.D.; PhD; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phosphatides; Phospholipids; Physiologic pulse; Plasma Membrane; Play; Poland; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Preparation; Prevention; Process; Property; Property, LOINC Axis 2; Protein Tyrosine Kinase p56(lck); Protein/Amino Acid Biochemistry, Molecular Modeling; Proto-Oncogene Protein c-lck; Proto-Oncogene Protein lck; Proto-Oncogene Tyrosine-Protein Kinase LCK; Protocol; Protocols documentation; Publications; Pulse; Research; Research Associate; Research Personnel; Research Resources; Researchers; Resistance; Resources; Role; Schools, Medical; Science; Scientific Publication; Scientist; Senescence; Side; Simulate; Simulation, Computer based; Specialist; Spectroscopy, ESR; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Spin Labels; Staging; Sterols; Structure; Structure of cortex of lens; Surface; System; System, LOINC Axis 4; T-Cell Specific Protein Tyrosine Kinase; TR3; Temperature; Testing; Third-World Countries; Third-World Nations; Time; Under-Developed Countries; Under-Developed Nations; United States National Institutes of Health; Universities; Visit; Wisconsin; age dependent; age related; aged; aminoacid; balance; balance function; base; biological systems; cataractogenesis; cataractous lenses; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; cross-link; crosslink; design; designing; disease/disorder; electron paramagnetic resonance spectroscopy; experiment; experimental research; experimental study; fiber cell; fluid; heavy metal Pb; heavy metal lead; improved; in silico; insight; interest; lck Kinase; lens; lens cortex; lipid bilayer membrane; lipid raft; liquid; medical schools; membrane model; membrane permeability; membrane structure; molecular dynamics; molecular modeling; oxygen transport; p56 lck; parent grant; physical property; plasmalemma; post-doc; post-doctoral; prevent; preventing; public health relevance; research study; resistant; senescent; simulation; social role; theories; virtual simulation",Is Cholesterol Crystalline Domain a Barrier to Oxygen Transport in the Eye Lens?,,8052,ICP1,International and Cooperative Projects - 1 Study Section,,2,32486,
7760921,R03,TW,5,,01/01/2010,12/31/2010,PAR-07-335,5R03TW008053-02,,FIC:34439;,2010,FOGARTY INTERNATIONAL CENTER,,BOSTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,08,149617367,US,MA,02115,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),"DURAISINGH, MANOJ T;",7628536;,5R03TW008053,02/01/2009,12/31/2011,"ATGN; Address; Affinity; Affinity Chromatography; Alleles; Allelomorphs; Antibodies; Antigens; Apical; Binding Proteins; Biochemical; Biochemical Genetics; Blood Serum; Blood erythrocyte; Blood normocyte; Blood reticulocyte; C-terminal; Cell Communication and Signaling; Cell Signaling; Cells; Charge; Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Chromatography, Affinity; Collaborations; Complement; Complement Proteins; Consultations; Culture Procedure; Cytoplasmic Domain; Cytoplasmic Tail; Data; Development; Diffusely basophilic erythrocyte; Disease; Disorder; Doctor of Philosophy; Drug resistance; Drugs; Epidemiology; Erythrocytes; Erythrocytic; Event; Family; Family member; Fusion Protein; Future; Gene Deletion; Gene Family; GeneHomolog; Generations; Genetic; Genetic Polymorphism; Genetic, Biochemical; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; Grant; HOSP; Head; Homolog; Homologous Gene; Homologue; Hospitals; Human; Human, General; Immune; Immune response; Immune system; Immunity; In Vitro; Infection; Infrastructure; Institution; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Invaded; Knock-out; Knockout; Knowledge; Label; Laboratories; Laboratory culture; Lead; Ligand Binding Protein; Ligands; Malaria; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Marrow reticulocyte; MeSH Descriptors Class 4; Measures; Medication; Membrane; Method LOINC Axis 6; Methodology; Methods; Molecular; Molecular Analysis; Multigene Family; Mutate; Nature; Organelles; Paludism; Parasites; Parents; Pathology; Pathway interactions; Patients; Pb element; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Plasmodium vivax; Play; Polychromatophilic Erythrocyte; Polymorphism (Genetics); Polymorphism, Genetic; Population; Process; Protein Binding; Proteins; Public Health Schools; Receptor Protein; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relative; Relative (related person); Research; Research Infrastructure; Reticulocytes; Reticuloendothelial System, Erythrocytes; Role; Sampling; Schools, Public Health; Scientist; Senegal; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Students; Surface; TM Domain; TXT; Tail; Testing; Text; Training; Transcript; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Transmission; Two Hybrid; Universities; Vaccine Design; Variant; Variation; Virulence; Work; Writing; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; affinity purification; base; biological signal transduction; blood corpuscles; body system, allergic/immunologic; chymotrypsin; clinical research site; clinical site; combat; design; designing; disease/disorder; drug resistant; drug/agent; erythrocyte receptor; experience; field study; functional outcomes; gene deletion mutation; gene product; geographic site; heavy metal Pb; heavy metal lead; host response; immunogen; immunogenicity; immunoresponse; in vivo; insight; international center; member; membrane structure; mutant; novel; organ system, allergic/immunologic; paralog; paralogous gene; parasite invasion; parent grant; pathway; polymorphism; positional cloning; professor; protein complex; public health relevance; receptor; resistance to Drug; resistant to Drug; response; reverse genetics; rhoptry; social role; stem; trafficking; transmission process; vaccine development; yeast two hybrid system",Molecular analysis of erythrocyte invasion in malaria isolates from Senegal,,8053,ICP1,International and Cooperative Projects - 1 Study Section,,2,34439,
7758284,R03,TW,5,,12/01/2009,11/30/2010,PAR-07-335,5R03TW008214-02,,FIC:33788;,2010,FOGARTY INTERNATIONAL CENTER,,SAN ANTONIO,UNITED STATES,PEDIATRICS,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"MELBY, PETER C.;",1948949;,5R03TW008214,01/15/2009,11/30/2011,"A-152E5.1; A-152E5.3; ABCD-1; ABCD-2; ATGN; Achyrocline; Address; American Cutaneous Leishmaniasis; Animal Model; Animal Models and Related Studies; Animals; Antigens; Area; Armed Forces Personnel; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Binetrakin; Biology; Blood monocyte; CCL17; CCL17 gene; CCL22; CCL22 gene; CCL3; CCL3 gene; CSIF; CSIF-10; Cessation of life; Chronic; Clinical; Collaborations; Colombia; Cricetinae; Cutaneous; Cutaneous Leishmaniasis; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); D12S1644; DC/B-CK; Death; Diathesis; Disease; Disease Resistance; Disease susceptibility; Disorder; Drugs; Epidemic; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Fostering; Foundations; G0S19-1; Genes; Grant; Hamsters; Healed; Hepatic Proliferation Inhibitor; Human; Human, General; Hypersensitivity skin testing; IL-10; IL-13; IL-4; IL-4-STAT; IL10; IL10A; IL13; IL4; IL4 Protein; Immune response; Immunity; In Vitro; India; Individual; Infection; Infrastructure; Interleukin 10 Precursor; Interleukin-10; Interleukin-13; Interleukin-4; Interleukin-4 Precursor; Investigation; Investigators; Kala-Azar; Killings; L arginine amidinohydrolase; LD78ALPHA; Leishmania; Leishmania (genus); Leishmaniasis; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Liver Immunoregulatory Protein; Liver-Derived Inhibitory Protein; Lymphocyte Stimulatory Factor 1; MCGF-2; MDC; MGC34554; MIP-1-alpha; MIP1A; Macrophage Activation; Mammals, Hamsters; Mammals, Mice; Man (Taxonomy); Man, Modern; Marcela; Marriage; Marrow monocyte; Mast Cell Growth Factor-2; Mediating; Medication; Metabolic Pathway; Mice; Military; Military Personnel; Modeling; Mucocutaneous leishmaniasis; Murine; Mus; NIH; NOS2; NOS2A; NOS2A gene; National Institutes of Health; National Institutes of Health (U.S.); National Research Council; National Research Council (U.S.); Nature; Parasites; Pathogenesis; Pathway interactions; Patients; Permissivenesses; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Population; Population Study; Position; Positioning Attribute; Predisposition; Preparation; Preventive; Production; Programs (PT); Programs [Publication Type]; Progressive Disease; RNA, Small Interfering; Reaction; Relative; Relative (related person); Research; Research Activity; Research Infrastructure; Research Personnel; Research Proposals; Researchers; Resistance; Resistance, Disease; Role; SCYA17; SCYA22; SCYA3; STAT6; STAT6 gene; STAT6B; STAT6C; STCP-1; Seminal; Skin Tests; Small Interfering RNA; Soldier; Staging; Students; Sudan; Susceptibility; T-Cell Growth Factor 2; TARC; Testing; Therapeutic Intervention; Training; Travel; United States National Institutes of Health; Universities; Up-Regulation; Up-Regulation (Physiology); Upregulation; Vector-borne disease; Vector-borne infectious disease; Vector-transmitted disease; Vector-transmitted infectious disease; Visceral; Visceral Leishmaniasis; Visit; Work; Writing; acquired immunity; arginase; arginine amidinase; canavanase; chemotherapy; cohort; college student; cytokine; design; designing; disease/disorder; disease/disorder proneness/risk; drug/agent; healing; host response; human disease; hypersensitivity test; immunogen; immunologic skin test; immunoresponse; impaired capacity; in vitro Model; in vivo; interest; intervention therapy; liability to disease; macrophage; meetings; member; model organism; monocyte; parent grant; pathway; permissiveness; pre-clinical; preclinical; professor; programs; public health relevance; resistance mechanism; resistance to disease; resistant; resistant disease; resistant mechanism; resistant to disease; response; siRNA; social role; university student",NOS2 and arginase in visceral leishmaniasis-FIRCA supplement,,8214,ICP1,International and Cooperative Projects - 1 Study Section,,2,33788,
7769505,R13,AG,5,,02/01/2010,12/31/2010,PA-06-041,5R13AG029767-02,,NIA:44550;,2010,NATIONAL INSTITUTE ON AGING,,AUSTIN,UNITED STATES,NONE,21,170230239,US,TX,78713,UNIVERSITY OF TEXAS AUSTIN,"ANGEL, JACQUELINE L.;",1912640;,5R13AG029767,02/15/2009,12/31/2010,"African American; Afro American; Afroamerican; Age; Age Group Unspecified; Aged 65 and Over; Aging; Aging Process; Aging-Related Process; American; Americas; Behavior; Biological Factors; Biology; Black Populations; Black or African American; Budgets; Categories; Censuses; Chicanas; Chicanos; Complex; Consensus; Country; Educational workshop; Elderly; Elderly, over 65; Factor, Biologic; Fertility Rates; Goals; Grips; Health; Health system; Healthy People 2010; Hispanic Populations; Hispanics; Hispanics or Latinos; Illness Behavior; Immigrations; In-Migration; Individual; Intervention; Intervention Strategies; Latino Population; Long-Term Care; Medical; Mexican; Mexican Americans; Mexico; Minority; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural Products; Non-Hispanic; Not Hispanic or Latino; Policies; Population; Public Health; Public Policy; Rates, Fertility; Research; Senescence; Series; Shapes; Sick Role; Spanish Origin; Time; United States; United States National Institutes of Health; Vacuum; Workshop; advanced age; age group; black American; conference; design; designing; disability; disease prevention; disorder prevention; elders; extended care; geriatric; grasp; health disparities; health disparity; hispanic community; interventional strategy; knowledge base; late life; later life; older adult; older person; psychologic; psychological; public health medicine (field); senescent; senior citizen; social; symposium",Conference Series on Aging in the America: United States and Mexico," Hispanics, especially those of Mexican ancestry, are re-shaping the demographic composition of the U.S. Hispanics are the fastest growing demographic group in the country, due to high immigration from Mexico and other Latin American countries, as well as higher fertility rates compared with non-Hispanic Whites and African-Americans (Tienda and Mitchell, 2006). In 2000, Hispanics became the nation's largest minority category. The Hispanic population has reached 36 million people, representing nearly 13 percent of the U.S. population. Mexican-origin Hispanics represent over half of that 36 million (U.S. Census Bureau, 2003). Moreover, the Hispanic population is aging, and as a result of their health issues and long-term medical needs, the health and wellbeing of this group is fast becoming a critical public policy concern (Angel and Hogan, 2004). A Conference Series focused specifically on increasing scholarly research into the aging process of the Mexican-origin population is vital. We believe this Conference Series will make a substantive contribution to the knowledge base, filling a significant vacuum of information on an understudied group of aging Americans. The consensus objective of the Series will inform the NIH Healthy People 2010 initiative to create national health objectives designed to identify the most significant preventable threats to health and to establish national goals to reduce these threats.",29767,NIA,National Institute on Aging Initial Review Group,,2,44550,
7753887,R13,AI,5,,02/01/2010,01/31/2011,PAR-03-176,5R13AI066859-05,,NIAID:25000;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WASHINGTON,UNITED STATES,,00,072643117,US,DC,20036,AMERICAN SOCIETY FOR MICROBIOLOGY,"WUBAH, DANIEL A.;",2256040;,5R13AI066859,02/15/2006,01/31/2011,"Age; American; Area; Award; Collaborations; Communication; Curriculum; Education; Educational Curriculum; Educational aspects; Educational process of instructing; Ensure; Ethnic Origin; Ethnic and Racial Minorities; Ethnicity; Ethnicity aspects; Faculty; Funding Agency; Funding Source; Gender; Grant; Institution; Leadership; Learning; Mentors; Microbiology; Minority; Minority Groups; Minority-Serving Institution; Paper; Participant; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Publications; Race; Racial Group; Research; Research Associate; Research Resources; Resources; Science; Science of Microbiology; Scientific Publication; Services; Societies; Stocks, Racial; Students; Teaching; Time; Travel; Underrepresented Minority; base; career; cost; meetings; member; post-doc; post-doctoral; programs; under-represented minority; underserved minority; volunteer; web site",ASM General Meeting Minority Travel Grant Program,,66859,ZAI1,Special Emphasis Panel,,5,25000,
7749045,R13,DA,5,,01/01/2010,12/31/2010,PA-06-041,5R13DA024494-03,,NIDA:24876;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,NONE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HSER, YIH-ING ;",1887833;,5R13DA024494,01/30/2008,12/31/2012,Award; Educational workshop; Ensure; Equipment; Institutes; Investigators; Learning; Methods; Participant; Population; Qualifying; Recruitment Activity; Research; Research Personnel; Researchers; Scholarship; Students; Travel; Workshop; conference; recruit; symposium; web site,CALDAR Institute on Longitudinal Research Findings and Methods,,24494,ZDA1,Special Emphasis Panel,,3,24876,
7755362,R13,DC,5,,02/01/2010,01/31/2011,PA-06-041,5R13DC006616-07,,NIDCD:44400;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,BOYS TOWN,UNITED STATES,,02,073136806,US,NE,68010,FATHER FLANAGAN'S BOYS' HOME,"GORGA, MICHAEL P;",1909223;,5R13DC006616,02/20/2004,01/31/2012,American; Auditory; Basic Research; Basic Science; Clinic; Clinical; Clinical Research; Clinical Study; Communities; Development; Discipline; ENT; Environment; Equilibrium; Feedback; Fostering; Funding; Grant; Hearing; Individual; Industry; Intervention; Intervention Strategies; Investigators; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; NIH; NIH RFA; National Institutes of Health; National Institutes of Health (U.S.); Otolaryngologist; Patient Care; Patient Care Delivery; Physicians; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Request for Applications; Research; Research Associate; Research Personnel; Researchers; Scholarship; Scientist; Seasons; Societies; Staging; Students; Technology; Training; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Travel; United States National Institutes of Health; Work; balance; balance function; career; conference; fundamental research; hearing perception; improved; interest; interventional strategy; language translation; lectures; meetings; member; next generation; post-doc; post-doctoral; programs; sound perception; success; symposium; translation research enterprise,Building the Next Generation of Clinical Researchers - American Auditory Society,,6616,CDRC,Communication Disorders Review Committee,,7,44400,
7761251,R13,GM,5,,02/01/2010,01/31/2011,PA-06-041,5R13GM086957-02,,NIGMS:1;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHARLESTON,UNITED STATES,BIOCHEMISTRY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"HANNUN, YUSUF AWNI;",1873077;,5R13GM086957,02/01/2009,01/31/2014,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-; 4-Sphingenine; Address; Area; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Cancer Biology; Cellular biology; Ceramide (lipids); Ceramides; Cutaneous Disorder; Dermatoses; Development; Dysfunction; Enzymes; Explosion; Faculty; Functional disorder; Funding; INFLM; Inflammation; International; Investigation; Investigators; Lipids; Math Models; Nerve Degeneration; Neuron Degeneration; Pathogenesis; Phosphates; Physiopathology; Postdoc; Postdoctoral Fellow; Research; Research Associate; Research Personnel; Researchers; Role; Skin Diseases; Skin Diseases and Manifestations; Sphingolipids; Sphingosine; Therapeutic; Translational Research; Translational Research Enterprise; Translational Science; Travel; Trees; Work; analog; atheromatosis; atherosclerotic vascular disease; base; cell biology; conference; field study; graduate student; inhibitor; inhibitor/antagonist; inorganic phosphate; insight; mathematical model; mathematical modeling; neural degeneration; neurodegeneration; neuronal degeneration; new approaches; novel; novel approaches; novel strategies; novel strategy; pathophysiology; post-doc; post-doctoral; public health relevance; skeletal disorder; skin disorder; social role; symposium; translation research enterprise",Support for the Charleston Ceramide Conference," PROJECT NARRATIVE This application seeks partial funding for an upcoming international conference, the fifth Charleston Ceramide Conference (CCC5) to be held March 11-14, 2009 at the Double Tree, Charleston, SC with expected 200 attendees (and approximately the same date in 2011 and 2013). ",86957,ZGM1,Special Emphasis Panel,,2,1,
7768434,R13,HL,5,,03/01/2010,02/28/2011,PAR-03-176,5R13HL084893-05,,NHLBI:15000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,PATHOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"RUDEL, LAWRENCE L;",1869588;,5R13HL084893,03/01/2006,02/28/2011,"Activities, Educational; American Heart Association; Applications Grants; Area; Arteriosclerosis; Assimilation; Assimilations; Basic Research; Basic Science; Biology; Blood Vessels; Cardiovascular Diseases; Clinical; Collaborations; Colorado; Communities; Data; Development; Discipline; Educational Activities; Eye; Eyeball; Future; Generalized Growth; Goals; Grant Proposals; Grants, Applications; Growth; History; Individual; Intermediary Metabolism; International; Investigators; Knowledge; METBL; Metabolic Processes; Metabolism; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutrition; Nutritional Science; Oral; Participant; Persons; Physical activity; Posters; Posters [Publication Type]; Recording of previous events; Reporting; Research; Research Personnel; Researchers; Science of nutrition; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Site; Students; Thrombosis; Time; Tissue Growth; Translations; United States National Institutes of Health; Work; abstracting; cardiovascular disorder; clinical applicability; clinical application; conference; design; designing; falls; insight; meetings; member; new technology; nutrition; ontogeny; posters; preclinical study; scientific accomplishments; scientific advances; success; symposium; translational study; trend; vascular","7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology",,84893,ZHL1,Special Emphasis Panel,,5,15000,
7766965,R13,MH,5,,02/01/2010,01/31/2011,PA-06-041,5R13MH079632-04,,NIMH:1;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,WEST KINGSTON,UNITED STATES,,02,075712877,US,RI,02892,GORDON RESEARCH CONFERENCES,"SPRUSTON, NELSON P.;",1891053;,5R13MH079632,02/15/2007,01/31/2012,"Dendrites; Disease; Disorder; Health; Investigators; Methods and Techniques; Methods, Other; NIH RFA; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Request for Applications; Research; Research Personnel; Researchers; Role; Structure; Synapses; Synaptic; Techniques; Work; conference; disease/disorder; graduate student; information processing; meetings; neuronal; social role; symposium","2006 Dendrites: Molecules, Structure and Function (Gordon Research Conference)",,79632,ZMH1,Special Emphasis Panel,,4,1,
7760116,R13,NS,5,,02/01/2010,01/31/2011,PAR-03-176,5R13NS043190-08,,NINDS:9000;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,BIOLOGY,05,837322494,US,GA,303023999,GEORGIA STATE UNIVERSITY,"KATZ, PAUL S;",1900877;,5R13NS043190,03/01/2002,01/31/2011,"Behavior; Educational workshop; Exposure to; Fellowship; Florida; Goals; Institution; International; Interview; Investigators; Laboratories; Location; Nerve Net; Nervous; Neurobiology; Neurosciences; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Research; Research Associate; Research Personnel; Researchers; Scientist; Site; Societies; Southeast U.S.; Southeast US; Southeastern United States; Students; System; System, LOINC Axis 4; Training; Travel; Universities; Woman; Work; Workshop; base; career; comparative; conference; meetings; neural; neurobiological; outreach program; post-doc; post-doctoral; posters; relating to nervous system; skills; success; symposium",South East Nerve Net Conference,,43190,ZNS1,Special Emphasis Panel,,8,9000,
7753908,R21,AA,5,,01/01/2010,12/31/2010,PA-06-295,5R21AA016360-02,,NIAAA:228690;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,INDIANAPOLIS,UNITED STATES,SURGERY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"SCHMIDT, CHRISTIAN MAXIMILLIAN;",8087173;,5R21AA016360,01/01/2009,12/31/2010,"21+ years old; 5-BrdU; 5-Bromo-2'-deoxyuridine; 5-Bromodeoxyuridine; 5-Bromouracil deoxyriboside; 5-Bromouracil-2-deoxyriboside; 5-Budr; ALDH; Adult; Alcohol Drinking; Alcohol consumption; Alcoholism; Alcohols; Animal Model; Animal Models and Related Studies; Animals; Apoptosis; Apoptosis Pathway; BUdR; Blood Alcohol Content; Blood Serum; Blood alcohol level measurement; BrdU; Breeding; Bromodeoxyuridine; Bromodeoxyuridine (BUDR); Bromouracil Deoxyriboside; Broxuridine; CD31; CPE1; CYP2E; CYP2E1; CYP2E1 gene; CYPE1; Cancer Cause; Cancer Etiology; Cancers; Carcinoma of the Liver Cells; Causality; Cause of Death; Cell Communication and Signaling; Cell Death, Programmed; Cell Proliferative Activity; Cell Signaling; Cellular Proliferation Rate; Chemical Class, Alcohol; Common Rat Strains; Development; Diagnosis, Ultrasound; ETOH level; Eating; Echography; Echotomography; Enzymes; EtOH drinking; Etiology; Food; Food Intake; Grant; HCC; Hepatic; Hepatic Cancer; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Histology; Human, Adult; Hydrogen Oxide; Incidence; Intracellular Communication and Signaling; Lesion; Liver; MAP-ERK Kinase; MAPK ERK Kinases; MAPK Signaling Pathway; MAPK Signaling Pathway Pathway; MEKs; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Mammals, Rats; Measures; Medical Imaging, Ultrasound; Metabolic; Mitotic Index; Modeling; NDUL; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neoplasms; Nodule; Nutritional; Oncogenesis; Organ; P450-J; P450C2E; PECAM1; PECAM1 gene; Pathologic; Placebo Control; Primary carcinoma of the liver cells; Proliferation Index; Rat; Rats, Wistar; Rattus; Relative; Relative (related person); Research; Risk Factors; Role; S-Phase Fraction; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Solutions; Testing; Time; Tumors; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; United States National Institutes of Health; Uridine, 5-bromo-2'-deoxy-; Water; Wistar Rats; adult human (21+); alcohol accessibility; alcohol availability; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol level; alcohol measurement; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; aldehyde dehydrogenases; angiogenesis; biological signal transduction; blood alcohol concentration; blood alcohol level; body system, hepatic; diagnostic ultrasound; disease causation; disease etiology; disease/disorder etiology; disorder etiology; ethanol accessibility; ethanol availability; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol measurement; ethanol product use; ethanol use; ethyl alcohol measurements; etoh use; exposed to alcohol; exposure to alcohol; inhibitor; inhibitor/antagonist; liver cancer; male; malignancy; malignant liver tumor; model organism; neoplasia; neoplasm/cancer; neoplastic; neoplastic growth; organ system, hepatic; preference; public health relevance; social role; sonogram; sonography; sound measurement; tool; tumor; tumorigenesis; ultrasound; ultrasound imaging; ultrasound scanning; uptake",Mechanism of Alcohol/Alcoholism-induced Liver Neoplasia, Project Narrative The proposed research will involve characterizing two distinct animal models to show that prolonged alcohol intake leads to the development of liver cancer in the absence of other risk factors. Possible mechanisms involved will also be investigated. Such an animal model will be an invaluable tool for studying the mechanism by which alcohol exposure causes liver cancer and also further our understanding of the mechanisms by which alcohol causes cancer in general.,16360,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,228690,
7763942,R21,AA,5,,02/01/2010,01/31/2011,PA-06-557,5R21AA016531-02,,NIAAA:125483;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,NEW YORK,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"GRIFFIN, KENNETH W;",1915391;,5R21AA016531,02/01/2009,01/31/2011,"12-20 years old; Adaptation, Psychologic; Adaptation, Psychological; Adolescence; Affect; Age; Age of Onset; Alcohol Drinking; Alcohol Intoxication; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Analysis, Data; Automobile Driving; Behavior; Behavioral; Categories; Causality; Chemical Class, Alcohol; Cognitive; Control Groups; Data; Data Analyses; Data Set; Dataset; Development; Drivings, Automobile; Drug usage; Drugs; Drugs, Illicit; Drunkenness; Drunkennesses; ETOH level; Epidemiology; EtOH drinking; EtOH intoxication; Etiology; Expectancy; Factors, Psychological; Goals; Health; Illicit Drugs; Impaired Driving; Individual; Lead; Legal; Mediating; Medication; Minor; Motor Vehicles; New York; Occupational; Outcome; Participant; Patient Self-Report; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Policies; Prevention program; Programs (PT); Programs [Publication Type]; Psychological Factors; Psychological adjustment; Public Health; Records; Research; Risk; Risk Behaviors; Risk Factors; Risky Behavior; Self Management; Self-Report; Self-control as a personality trait; Sex Characteristics; Sex Differences; Social Environment; Societies; Testing; Time; Woman; Work; Youth Drinking; adolescence (12-20); adolescent alcohol use; adolescent drinking; adult youth; alcohol consequences; alcohol ingestion; alcohol intake; alcohol level; alcohol measurement; alcohol prevention; alcohol problem; alcohol product use; alcohol related problem; alcohol use; alcoholic beverage consumption; alcoholic drink intake; at risk behavior; binge alcohol consumption; binge drinking; cohort; design; designing; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drinking; driving; driving while impaired; drug abuse prevention; drug addiction prevention; drug use; drug use prevention; drug/agent; early adolescence; early alcohol use; episodic drinking; ethanol abuse; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol intoxication; ethanol measurement; ethanol product use; ethanol use; ethyl alcohol measurements; etoh use; gender difference; hazardous alcohol use; heavy metal Pb; heavy metal lead; high school; impaired driving performance; improved; men; men's; prevent; preventing; problem drinking; programs; psychologic; psychological; psychosocial; psychosocial adjustment; public health medicine (field); public health relevance; role model; self control; sexual dimorphism (noncellular); skills; social; social climate; social context; socioenvironment; substance abuse prevention; teen drinking; teenage; teenage drinking; treatment program; underage drinking; young adult",Adolescent Alcohol Use and Young Adult Psychosocial Functioning," PROJECT NARRATIVE A central goal of the proposed study is to examine how alcohol use during early adolescence affects subsequent alcohol and drug use/abuse, negative consequences of use, related risk behaviors, and other indicators of psychosocial adjustment during late adolescence and the transition to young adulthood. This will be accomplished via secondary data analyses of control group participants from a larger drug abuse prevention trial that assessed participants over a 13-year span from early adolescence to young adulthood. It is anticipated that the findings will improve public health by identifying key indicators and behavior patterns that place young people at risk for later alcohol-related and other problems, which can in turn be used to identify those individuals who could benefit most from targeted alcohol prevention or treatment programs.",16531,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,125483,
7753907,R21,AA,5,,01/01/2010,12/31/2010,PA-06-181,5R21AA016540-02,,NIAAA:231660;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHICAGO,UNITED STATES,BIOLOGY,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"HANSEL, CHRISTIAN ROBERT;",8547527;,5R21AA016540,01/01/2009,12/31/2010,"3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester; AMPA Receptors; Absolute ethanol; Acute; Affect; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcohols; Ammon Horn; Area; Basswood; Bathing; Baths; Bayer Brand of Nimodipine; Blood Coagulation Factor IV; Brain; CCD camera; Ca++ element; Calcium; Calcium Channel; Calcium Channel Antagonist Receptor; Calcium Ion Signaling; Calcium Phospholipid-Dependent Protein Kinase; Calcium Signaling; Calcium Spikes; Calcium-Activated Phospholipid-Dependent Kinase; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cells; Cerebellar Cortex; Cerebellar cortex structure; Cerebellum; Chemical Class, Alcohol; Coagulation Factor IV; Collaborations; Common Rat Strains; Complex; Cornu Ammonis; Data; Death Rate; Dendrites; Dose; ETOH; Encephalon; Encephalons; EtOH drinking; Ethanol; Excitatory Synapse; Factor IV; Fiber; Financial Support; Grain Alcohol; Hand; Hippocampus; Hippocampus (Brain); Image; Imaging Procedures; Imaging Techniques; Impairment; In Vitro; Intracellular Communication and Signaling; Ion Channels, Calcium; Laboratories; Lead; Learning; Lecithinases; Left; Linden; Location; Long-Term Depression (Neurophysiology); Long-Term Depression (Physiology); Long-Term Potentiation; Long-Term Synaptic Depression; Mammals, Rats; Maps; Measures; Mediating; Memory; Metabotropic Glutamate Receptors; Methods and Techniques; Methods, Other; Methylcarbinol; Mibefradil; Modeling; Monitor; Motor; Movement; N-Methyl-D-Aspartate Receptors; NIAAA; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; National Institute on Alcohol Abuse and Alcoholism; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Transmission; Neurocyte; Neurons; New Mexico; Nimodipine; Nimotop; Organism; Output; PKC; Patch-Clamp Technics; Patch-Clamp Techniques; Pb element; Phospholipase; Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Physiologic pulse; Physiology; Plastics; Play; Preparation; Probability; Process; Protein Kinase C; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein phosphatase; Protocol; Protocols documentation; Pulse; Purkinje Cells; Purkinje's Corpuscles; Rat; Rattus; Receptor Activation; Receptor Protein; Receptors, AMPA; Receptors, Calcium Channel Blocker; Receptors, Metabotropic Glutamate; Receptors, N-Methylaspartate; Reporting; Research; Rest; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Specificity; Speed; Speed (motion); Spikes, Calcium; Structure; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Tilia; Tilia (Plant); Time; Traffic accidents; Transmission; Universities; Update; V (voltage); VDCC; Voltage-Dependent Calcium Channels; Work; alcohol effect; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; biological signal transduction; body movement; cerebellar Purkinje cell; charge coupled device camera; data acquisition; design; designing; environmental change; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol use; etoh use; experience; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hippocampal; imaging; innovate; innovation; innovative; interest; living system; locomotor learning; long term depression; motor impairment; motor learning; neuronal; novel; patch clamp; postsynaptic; presynaptic; public health relevance; receptor; receptor function; research study; response; social role; tool; transmission process; voltage",The effects of alcohol on cerebellar synaotic transmission and plasticity," 7. Project Narrative The cerebellum is a brain structure involved in the fine-adjustment of motorcoordination and in motor learning. These processes can be impaired as a consequence of acute alcohol consumption, and yet acute alcohol effects on cerebellar synaptic transmission and on plasticity within cerebellar networks have not been studied so far. Here, we propose to examine alcohol effects on forms of cerebellar synaptic plasticity as well as the cellular causes for such effects using electrophysiological recording techniques and fluorometric calcium imaging techniques in rat brain slices.",16540,ZAA1,Special Emphasis Panel,,2,231660,
7753911,R21,AA,5,,01/01/2010,12/31/2010,PA-06-181,5R21AA017277-02,,NIAAA:243540;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BALTIMORE,UNITED STATES,NEUROLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"STINS, MONIQUE F.;",6064999;,5R21AA017277,01/01/2009,12/31/2010,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy)-, tetrasodium salt; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Absolute ethanol; Active Oxygen; Acute; Address; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Adexone; Adverse effects; Affect; Air Embolism; Aknichthol Dexa; Alba-Dex; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcohol-Related Disorders; Alcoholic; Alcoholic Beverages; Alcohols; Alin; Alin Depot; Alin Oftalmico; Ambene; Amentia; Amplidermis; Anemul mono; Animals; Antimicotico; Aquapred; Area; Astrocytes; Astrocytus; Astroglia; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Auxiloson; Azona; Azovan Blue; Bacterial Infections; Baycuten; Baycuten N; Behavior Disorders; Biological; Blood - brain barrier anatomy; Blood Plasma; Blood Vessels; Blood-Brain Barrier; Boozer; Brain; Cardiac Diseases; Cardiac Disorders; Cell Communication and Signaling; Cell Membrane Lipids; Cell Signaling; Cellular Matrix; Central Nervous System; Chemical Class, Alcohol; Chronic; Coenzyme II; Complex; Corson; Cortidexason; Cortisumman; Cytoskeletal System; Cytoskeleton; DNA Sequence Rearrangement; Data; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Dementia; Dependent drinker; Deronil; Desamethasone; Desameton; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Dose; Drugs; Dysfunction; ETOH; Electrical Resistance; Embolism, Air; Embolism, Gas; Encephalon; Encephalons; Endothelium; EtOH drinking; Ethanol; Evans Blue; Evans blue stain; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Functional disorder; Funding; Future; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gammacorten; Generations; Genetic Predisposition; Genetic Predisposition to Disease; Genetic Susceptibility; Glia; Glial Cells; Goals; Grain Alcohol; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heart Diseases; Hemato-Encephalic Barrier; Hexadecadrol; Hexadrol; Hortega cell; Human; Human, General; INFLM; Impairment; In Vitro; Inflammation; Inherited Predisposition; Inherited Susceptibility; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Kinetic; Kinetics; Knowledge; Kolliker's reticulum; Laboratories; Lead; Lipid Rafts, Cell Membrane; Lokalison-F; Loverine; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mebubarbital; Mediating; Medication; Membrane Lipids; Membrane Microdomains; Metabolic Processes; Metabolism; Methylcarbinol; Methylfluorprednisolone; Mice; Microglia; Millicorten; Modeling; Murine; Mus; Mymethasone; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Disorders; Neurological Disorders; Neuronal Dysfunction; Neurons; Nicotinamide-Adenine Dinucleotide Phosphate; Non-neuronal cell; Ocasa; Occluding Junctions; Orgadrone; Outcomes Research; Oxygen Radicals; Pathology; Pb element; Pentobarbital; Pentobarbitone; Permeability; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Plasma; Predisposition; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Pro-Oxidants; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protective Agents; Protective Drugs; Publications; Reactive Oxygen Species; Rearrangement; Receptor Protein; Research, Outcomes; Resistance, Electric; Reticuloendothelial System, Serum, Plasma; Scientific Publication; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Spersadex; Spersadox; Sphingolipid Microdomains; Sphingolipid-Cholesterol Rafts; Stimulus; Susceptibility; System; System, LOINC Axis 4; Testing; Therapeutic Intervention; Tight Junctions; Time; Treatment Period; Treatment Side Effects; Triphosphopyridine Nucleotide; Visumetazone; Work; Zonula Occludens; alcohol effect; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol research; alcohol testing; alcohol use; alcoholic beverage consumption; alcoholic drink intake; atheromatosis; atherosclerotic vascular disease; auricularum; bacterial disease; behavioral disorder; binge alcohol consumption; binge drinker; binge drinking; biological signal transduction; bout drinker; brain atrophy; brain research; cerebral atrophy; cognitive function; cortical atrophy; disease/disorder; dosage; drinking; drug/agent; episodic drinker; episodic drinking; ethanol abuse; ethanol consumption; ethanol drinking; ethanol effect; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol testing; ethanol use; ethanol-related disorder; etoh use; genetic etiology; genetic mechanism of disease; genetic vulnerability; gitter cell; hazardous alcohol use; heart disorder; heavy metal Pb; heavy metal lead; in vitro Model; in vivo; in vivo Model; intervention therapy; intracellular skeleton; lipid raft; mesoglia; microglial cell; microgliocyte; mouse model; nerve cement; nervous system disorder; neurobehavioral; neurological disease; neuronal; neurotoxic; novel; pathophysiology; perivascular glial cell; prevent; preventing; problem drinker; problem drinking; programs; public health relevance; receptor; side effect; solute; substantia alba; therapy adverse effect; treatment adverse effect; treatment days; treatment duration; vascular; white matter",Alcohol Mediated Blood Brain Barrier Dysfunction," Narrative  Drinking of alcoholic beverages affects the brain, resulting in behavioral disorders, affects cognitive functions and can even lead to dementia.  We found that alcohol negatively affected properties of the blood vessels in the brain, the so- called blood brain barrier (BBB), leading to an increased permeability to small solutes and this may worsen the effects of alcohol on the neuronal and glial cells inside the brain.  In this exploratory study, we propose to use and in vitro model of the human BBB and an in- vivo mouse model for alcohol use to further investigate the mechanisms whereby alcohol affects the BBB.",17277,ZAA1,Special Emphasis Panel,,2,243540,
7753904,R21,AA,5,,01/01/2010,12/31/2010,PA-06-181,5R21AA017494-02,,NIAAA:175725;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,NEW ORLEANS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,02,782627814,US,LA,70112,LOUISIANA STATE UNIV HSC NEW ORLEANS,"ZHANG, PING ;",7683879;,5R21AA017494,01/01/2009,12/31/2010,"APRF protein; Acute; Acute-Phase Response Factor; Address; Affect; Agranulocytosis; Alcohol abuse; Alcoholic; Alcohols; Animals; Attenuated; Bacterial Infections; Bacterial Pneumonia; Binding; Binding (Molecular Function); Biological Models; Blood granulocytic cell; Body Tissues; Bone Marrow; Boozer; CCND1 Protein; CDK; CDK Inhibitor Protein; CDKI Protein; Cell Communication and Signaling; Cell Cycle; Cell Cycle Arrest; Cell Division Cycle; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; CellLine; Cells; Cellular Proliferation; Cessation of life; Chemical Class, Alcohol; Chronic; Colony Stimulating Factor 3; Consumption; Cyclin D1; Cyclin Kinase Inhibitor; Cyclin-Dependent Kinase Inhibitor; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; D. pneumoniae; D.pneumoniae; Data; Death; Dependent drinker; Diplococcus pneumoniae; EC 2.7.2-; ERK MAP Kinases; Ethanol Metabolism; Extracellular Signal Regulated Kinases; Extracellular Signal-Regulated Kinase Gene; Extracellular Signal-Regulated Kinases; Extracellular Signal-Regulated MAP Kinases; Feedback; G1 Arrest; G1 Block; G1/S-Specific Cyclin D1; Granular Leukocytes; Granulocyte Colony-Stimulating Factor; Granulocytic cell; Granulocytopenia; Health; IL6-response factor; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Impairment; Infection; Intoxication; Intracellular Communication and Signaling; Investigation; Knowledge; LIF-response factor; Leukocytopenia; Leukopenia; Lung; MAP Kinase Gene; MAP kinase; MAP-ERK Kinase; MAPK; MAPK ERK Kinases; MEKs; Mammals, Mice; Marrow; Mice; Mitogen-Activated Protein Kinase Gene; Mitogen-Activated Protein Kinases; Model System; Modeling; Models, Biologic; Molecular Interaction; Mortality; Mortality Vital Statistics; Mother Cells; Murine; Mus; Myeloid Progenitor Cells; Oxidative Stress; PRAD1 Protein; Pathogenesis; Pathway interactions; Patients; Pluripoietin; Pneumococcal Pneumonia; Pneumococcus; Pneumonia; Pneumonia, Bacterial; Pneumonia, Lobar; Pneumonia, Pneumococcal; Pneumonitis; Production; Progenitor Cells; Proto-Oncogene Proteins c-bcl-1; Pulmonary Inflammation; Ras/Raf; Receptor Protein; Respiratory System, Lung; Reticuloendothelial System, Bone Marrow; S. pneumoniae; Signal Transducer and Activator of Transcription 3; Signal Transduction; Signal Transduction Systems; Signaling; Stat3 protein; Stem Cells, Myeloid; Stem cells; Streptococcus pneumoniae; Testing; Therapeutic; Therapeutic Intervention; Threonine/Tyrosine Protein Kinase; Time; Tissues; United States; alcohol effect; alcohol metabolism; alcohol problem; bacterial disease; bcl-1 Proto-Oncogene Products; bcl-1 Proto-Oncogene Proteins; bcl1 Proto-Oncogene Proteins; biological signal transduction; c-bcl-1 Proteins; cdk Proteins; cultured cell line; cyclin D; cytokine; effective therapy; ethanol abuse; ethanol effect; experiment; experimental research; experimental study; extracellular signal related kinase; granulocyte; granulocyte colony stimulating factor; hazardous alcohol use; immunosuppressed patient; in vitro Model; injured; intervention therapy; novel; pathway; problem drinker; problem drinking; pulmonary; receptor; research study; response",Alcohol and Impairment of the Granulopoietic Response to Pneumonia," Narrative Alcohol abuse predisposes the host to pneumonia which is a leading cause of infectious death in the United States. Many alcoholic patients with pneumonia present with leukopenia, which is frequently fatal. This project investigates the mechanisms underlying this serious health problem and will help to identify therapeutic approaches for effective treatment of alcoholic patients with severe lung infection.  ",17494,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,175725,
7767768,R21,AA,5,,02/01/2010,01/31/2011,PA-06-181,5R21AA017544-02,,NIAAA:203311;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,WORCESTER,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"SZABO, GYONGYI ;",1895808;,5R21AA017544,02/10/2009,01/31/2011,"Active Oxygen; Alcohol Drinking; Alcohol consumption; Alcoholic; Alcoholic Liver Diseases; Alcohols; Animals; Award; Body Tissues; Bone Marrow; Boozer; Budgets; Cancers; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Signaling; Cells; Chemical Class, Alcohol; Chemotherapy-Hormones/Steroids; Chimera; Chimera organism; Chronic; Cirrhosis; Complex; Dependent drinker; Development; Doctor of Philosophy; Endocrine Gland Secretion; Enzymes; EtOH drinking; Event; Fats; Fatty Liver; Fatty acid glycerol esters; Fibrosis; Funding; Gene Targeting; Gene Transcription; Generations; Genetic Transcription; Grant; HCC; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Hepatic Cells; Hepatic Disorder; Hepatic Failure; Hepatic Parenchymal Cell; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Hormones; Human; Human, General; Hypoxia; Hypoxia Inducible Factor; Hypoxic; INFLM; Immune; Individual; Inflammation; Inflammatory; Injury; Intracellular Communication and Signaling; Kupffer Cells; Laboratories; Link; Liver; Liver Cells; Liver Failure; Liver Steatosis; Liver diseases; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Messenger RNA; Mice; Mice, Transgenic; Murine; Mus; NADPH Oxidase; Oxygen Deficiency; Oxygen Radicals; Pathogenesis; Pathway interactions; Ph.D.; PhD; Play; Primary carcinoma of the liver cells; Pro-Oxidants; Production; Proteins; RNA Expression; RNA, Messenger; Reactive Oxygen Species; Reagent; Regulation; Reticuloendothelial System, Bone Marrow; Role; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stellate Sinusoidal Macrophage; System; System, LOINC Axis 4; Targetings, Gene; Testing; Therapeutic Hormone; Time; Tissues; Training; Transcription; Transcription, Genetic; Transgenic Mice; Up-Regulation; Up-Regulation (Physiology); Upregulation; Wild Type Mouse; alcohol effect; alcohol induced hepatic injury; alcohol induced liver disorder; alcohol induced liver injury; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcohol-induced hepatic dysfunction; alcohol-induced liver disease; alcohol-induced liver dysfunction; alcohol-mediated liver dysfunction; alcohol-mediated liver injury; alcoholic beverage consumption; alcoholic drink intake; biological signal transduction; body system, hepatic; cell type; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; cost; ethanol consumption; ethanol drinking; ethanol effect; ethanol induced hepatic injury; ethanol induced liver disorder; ethanol induced liver injury; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; ethanol-induced hepatic dysfunction; ethanol-induced liver disease; ethanol-induced liver dysfunction; ethanol-mediated liver dysfunction; ethanol-mediated liver injury; etoh use; experiment; experimental research; experimental study; feeding; gene product; hepatic steatosis; hepatopathy; hypoxia inducible factor 1; liver disorder; liver macrophage; mRNA; malignancy; mouse model; neoplasm/cancer; novel; organ system, hepatic; overexpression; pathway; problem drinker; public health relevance; research study; response; social role; therapeutic target; transcription factor",Hypoxia-inducible factors in alcoholic liver disease," PROJECT NARRATIVE Chronic alcohol consumption leads to fat accumulation and inflammation in the liver which over time leads to liver failure. The mechanisms of these alcohol-induced changes in the liver are only partially understood. In this study we will study the role of the hypoxia-inducible factor (HIF), which is a signal transduction molecule involved in fatty liver changes. We will study which specific cell types play a role in HIF-mediated liver damage. In addition, we will also investigate a enzyme system (NADPH) that produces reactive oxygen radicals after alcohol intake as a potential trigger for HIF activation and liver disease. Our studies will define specific therapeutic targets for potential treatment of alcoholic liver disease.",17544,AA,"Biochemistry, Physiology and Medicine Subcommittee",,2,203311,
7758708,R21,AG,5,,02/01/2010,12/31/2010,PA-06-181,5R21AG030632-02,,NIA:164502;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,SOCIAL SCIENCES,08,149617367,US,MA,02115,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),"KUBZANSKY, LAURA D;",1905062;,5R21AG030632,01/15/2009,12/31/2010,"0-11 years old; 21+ years old; 3beta-Hydroxyandrost-5-en-17-one; 5-Androsten-3-beta-hydroxy-17-one; Adaptation, Physiological; Adaptations, Physiologic; Address; Adult; Aeroseb-HC; Affect; Age; Aged 65 and Over; Aging; Androst-5-en-17-one, 3-hydroxy-, (3beta)-; Androstenolone; Animals; Applications Grants; Area; Biological; Biology; Blood Pressure; Buffers; Cardiac Output; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cetacort; Chemotherapy-Hormones/Steroids; Child; Child Youth; Children (0-21); Communities; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; DHEA; Dehydroisoandrosterone; Dermacort; Development; Disease; Disorder; Distress; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Eldecort; Elderly; Elderly, over 65; Endocrine Gland Secretion; Estrogenic Agents; Estrogenic Compounds; Estrogens; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Frequencies (time pattern); Frequency; Gender; Generalized Growth; Goals; Grant Proposals; Grants, Applications; Growth; Health; Hormones; Human; Human, Adult; Human, Child; Human, General; Hydrocortisone; Hydrocortone; Hytone; Investigation; Investigators; Laboratories; Lactation; Length of Life; Life; Life Cycle; Life Cycle Stages; Literature; Longevity; Man (Taxonomy); Man, Modern; Measures; Molecular; Mothers; Neurobiology; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nutracort; OXT; Ocytocin; Organ System, Cardiovascular; Outcome; Outcome Measure; Oxytocin; PBO; Participant; Pathway interactions; Pattern; Personal Satisfaction; Phenotype; Physiologic; Physiological; Physiological Adaptation; Placebo Control; Placebos; Play; Posterior Pituitary Hormones; Prasterone; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Preventive Intervention; Procedures; Process; Proctocort; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; R21 Award; RPG; Randomized; Recombinant Oxytocin; Recruitment Activity; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Role; Sampling; Senescence; Sham Treatment; Social Interaction; Social support; Solid; Stress; System; System, LOINC Axis 4; Testing; Therapeutic Dehydroepiandrosterone; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Hydrocortisone; Time; Tissue Growth; Vascular resistance; Vascular, Heart; Woman; Work; adult human (21+); adult youth; advanced age; biobehavior; biobehavioral; children; circulatory system; dehydroepiandrosterone; disease/disorder; early life exposure; elders; emotional experience; emotional factor; experience; experiment; experimental research; experimental study; geriatric; heart output; heart rate variability; insight; interdisciplinary approach; late life; later life; life course; life span; lifespan; men; men's; multidisciplinary; neurobiological; neurohypophyseal hormone; novel; older adult; older person; ontogeny; pathway; preventional intervention strategy; programs; protective effect; psychologic; psychological; public health relevance; randomisation; randomization; randomly assigned; recruit; reproductive; research study; resilience; response; senescent; senior citizen; sham therapy; social; social attachment; social bonding; social role; social stress; social support network; stress buffering; stress management; theories; well-being; young adult; youngster","The Biology of Resilience: Oxytocin, Social Relationships and Health"," Project Narrative Relevance The proposed work has the potential to provide new insight into the biological mechanisms underlying the protective effects of positive social relationships on health. This experimental study utilizes a multidisciplinary approach focusing on the interplay between molecular, psychological, and social processes as they relate to aging, and will provide a solid platform from which to launch a larger program of research. Ultimately, a neurobiological understanding of resilience may inform efforts for both prevention and intervention of diseases or problems common in later life.",30632,MESH,"Biobehavioral Mechanisms of Emotion, Stress and Health Study Section",,2,164502,
7759175,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI072461-02,,NIAID:188719;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"SATCHELL, KARLA J. F.;",1932888;,5R21AI072461,02/01/2009,01/31/2011,"Accounting; Adoptive Transfer; Animal Model; Animal Models and Related Studies; Antibodies; Bacteria; Basophilic Histiocyte; Basophils, Tissue; Blood Coagulation Factor I; Blood Coagulation Factor One; Blood Factor One; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Cell Function; Cell Process; Cell Protection; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cholera; Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin; Choleragen; Coagulation Factor I; Coagulation Factor One; Complement; Complement Proteins; Cytoprotection; Data; Defect; Disabled Persons; Disabled Population; Disease; Disorder; Epidemic; Epidemiology; Excretory function; Factor I; Factor One; Fibrinogen; Frequencies (time pattern); Frequency; GALT; Gastrointestinal Tract, Small Intestine; Genetic; Grant; Gut associated lymphoid tissue; HA-protease; Handicapped; Hemalysins; Hemolysin; Heterophil Granulocyte; Host Defense; Immune; Immune Function, Cellular; Immune response; Immune system; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Individual; Infection; Infectious Agent; Intestinal; Intestines; Intestines, Small; Lymph node proper; Mammals, Mice; Marrow Mast Cell; Marrow Neutrophil; Mediating; Mesenteric; Mesentery; Mice; Murine; Mus; Natural Immunity; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Pathogenesis; Pattern; People with Disabilities; Persons; Persons with Disabilities; Peyer's Patches; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Recruitment Activity; Research Design; Reticuloendothelial System, Lymph Node; Role; Severities; Small Intestines; Structure of aggregated lymphoid follicle of small intestine; Study Type; Subcellular Process; Time; Toxin; Transmission; V. cholerae; V. cholerae O1; V. cholerae Serogroup O1; V.cholerae; Vibrio; Vibrio cholerae; Vibrio cholerae O1; Vibrio cholerae Serogroup O1; Vibrio comma; Virulence; body system, allergic/immunologic; bowel; cell type; communicable disease transmission; defined contribution; disabled; disabled people; disease transmission; disease/disorder; excretion; experiment; experimental research; experimental study; hemagglutinin-protease; host response; immune clearance; immune function; immunoresponse; in vivo; infectious disease transmission; infectious organism; lymph gland; lymph nodes; mast cell; mastocyte; model organism; mutant; neutrophil; organ system, allergic/immunologic; pandemic; pandemic disease; public health relevance; recruit; research study; small bowel; social role; study design; transmission process",Accessory toxin-mediated evasion of innate immunity during V. cholerae infection," Lay summary Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide. The epidemiology of modern cholera is distinct from the Classical disease as epidemics are caused by lower virulence strains that induce a high frequency of mild or asymptomatic infections. This prolonged period of vibrio excretion likely contributes to transmission of disease. Using a new animal model of cholera, accessory toxins hemolysin and RTX are shown to be key factors in prolonging intestinal colonization by V. cholerae. This project will investigate key components of the immune response to V. cholerae and identify is accessory toxins are associated with disabling innate immunity.",72461,ZRG1,Special Emphasis Panel,,2,188719,
7760941,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI074791-02,,NIAID:196144;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BUFFALO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,26,038633251,US,NY,14260,STATE UNIVERSITY OF NEW YORK AT BUFFALO,"RUSSELL, MICHAEL W;",1865209;,5R21AI074791,02/01/2009,01/31/2011,"4q Chemokine; ATGN; Acute; Antibiotic Resistance; Antibody Formation; Antibody Production; Antibody Response; Antigen Variation; Antigenic Variability; Antigenic Variation; Antigens; Area; B cell activating factor; B cell differentiation factor; B cell growth factor; B cell stimulating factor 2; B-Cell Differentiation Factor-1; B-Cell Differentiation Factor-2; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; B-Cell Stimulatory Factor-2; BAF; BCDF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF-2; BSF1; BSF1 (B cell stimulating factor 1); BSF2; BSF2 (B cell stimulating factor 2); Bacteria; Bears; Binetrakin; Blood; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood Serum; Body Tissues; C-X-C Chemokines; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CDC; CTLA-8; CTLA8; CXC Chemokines; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Signaling; Cell secretion; Cells; Cells, CD4; Cellular Secretion; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Complement; Complement Proteins; Comprehension; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Defense Mechanisms; Development; Diagnostic; Differentiation Factor, B-Cell; Difficulty conceiving; Disease; Disorder; Ectopic Pregnancy; Edodekin Alfa; Exudate; Female; Future; Generations; Genital; Genital System, Female, Vagina; Genital system; Gonococcal Infection; Gonococcus; Gonorrhea; HPGF; Health Sciences; Health, Reproductive; Helper Cells; Helper T-Cells; Helper-Inducer T-Lymphocyte; Hepatocyte-Stimulating Factor; Heterophil Granulocyte; Human; Human, General; Hybridoma Growth Factor; IFN; IFN-beta 2; IFNB2; IL-12; IL-17; IL-17A; IL-22; IL-23; IL-4; IL-6; IL12; IL17; IL17 Protein; IL17A; IL4; IL4 Protein; IL6 Protein; Immune; Immune response; Immune system; Immunity; Immunology; Immunology (Including BRMP); Immunology (NCI Program); In Vitro; Incidence; Inducer Cells; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infertility; Inflammatory; Inflammatory Response; Interferons; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin Receptor; Interleukin-12; Interleukin-17; Interleukin-4; Interleukin-4 Precursor; Interleukin-6; Interleukins; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Knock-out; Knockout; Lead; Life; Lymphocyte Stimulatory Factor 1; Lymphoid; MCGF-2; MGI-2; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Mast Cell Growth Factor-2; Mediating; Mice; Modeling; Mononuclear; Murine; Mus; Myeloid Differentiation-Inducing Protein; N. gonorrhoeae; N.gonorrhoeae; NKSF; Natural Killer Cell Stimulatory Factor; Neisseria gonorrhoeae; Neutrophil Infiltration; Neutrophil Recruitment; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Outcome; Pathway interactions; Pb element; Pelvic Inflammatory Disease; Phagocytes; Phagocytic Cell; Plasmacytoma Growth Factor; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Pregnancy, Ectopic; Probability; Production; Receptor Protein; Recruitment Activity; Relative; Relative (related person); Reporting; Reproductive Health; Research Specimen; Resistance; Resistance to antibiotics; Resistance, Antibiotic; Resistant to antibiotics; Reticuloendothelial System, Blood; Risk; Role; Secondary to; Serum; Services; Severities; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specimen; T-Cell Growth Factor 2; T-Cells, Helper-Inducer; T-Lymphocytes, Helper; T-Lymphocytes, Inducer; T4 Cells; T4 Lymphocytes; Testing; Th-1 Cell; Th-2 Cell; Th1 Cells; Th2 Cells; Tissues; Type 1 Helper Cell; Type 2 Helper Cell; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Ursidae; Ursidae Family; Vaccines; Vagina; Vaginal; Wild Type Mouse; Woman; alpha-Chemokines; amebocyte; antibiotic resistant; antibody biosynthesis; biological signal transduction; body system, allergic/immunologic; congenic; cytokine; disease/disorder; extrauterine pregnancy; genital secretion; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunoglobulin biosynthesis; immunoresponse; improved; in vivo; infertile; interferon beta 2; interleukin-22; interleukin-23; interventional strategy; male; mouse model; neutrophil; new approaches; novel; novel approaches; novel strategies; novel strategy; organ system, allergic/immunologic; pathogen; pathway; psychological defense mechanism; public health relevance; receptor; recruit; resistant; response; social role; unable to bear children; unspecified interleukin; urogenital system (genital part)",Gonococcal Inflammatory Immune Responses," Project Narrative Gonorrhea is the second-most-frequent, notifiable infectious disease in the United States and the CDC reports over 300,000 cases in recent years [59], although the true incidence is believed to be double that figure; world- wide incidence is estimated to be over 60 million new infections per year [60]. Women bear the brunt of the infection which can lead to serious reproductive health problems including pelvic inflammatory disease, infertility, and risk for ectopic pregnancy, and while it is well known that gonorrhea does not generate immunity to repeated infection, no vaccines exist to control it and antibiotic resistance is spreading. This proposal will apply important new findings from the field of immunology to determine the way in which the immune system interacts with the gonococcus bacterium, an area that is poorly understood at present.",74791,IHD,Immunity and Host Defense Study Section,,2,196144,
7770879,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI075177-02,,NIAID:227254;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,AURORA,UNITED STATES,PHARMACOLOGY,07,041096314,US,CO,800452505,UNIVERSITY OF COLORADO DENVER,"CHURCHILL, MAIR E;",1968529;,5R21AI075177,02/15/2009,01/31/2011,"3-D structure; 3-dimensional structure; 3D structure; Activation, Gene; Adipocytes; Adipose Cell; Amino Acids; Architecture; Assay; B blood cells; B cell receptor; B-Cell Development; B-Cells; B-Lymphocytes; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; C 3-5 Converting Enzyme; C3 Proactivator; C3PA; CVFBb; Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Code; Coding System; Complement 3 Proactivator; Complement Factor B; Complement Factor B, Alternative Pathway; Complement Protein B; Complement Protein Factor B; Complex; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; DNA; DNA Binding; DNA Binding Domain; DNA Binding Interaction; DNA Methylation; Deoxyribonucleic Acid; Development; Dimerization; Disease; Disorder; Elements; Engineering / Architecture; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Factor B; Fat Cells; Flies; Future; Gene Action Regulation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Gene Targeting; Genes; Genes, Regulator; Genetic; Genetics-Mutagenesis; HLH Motifs; HTH DNA Binding Domain; HTH Motifs; Helix-Loop-Helix Domain; Helix-Loop-Helix Motifs; Helix-Turn-Helix Motifs; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; In Vitro; Individual; Knowledge; Laboratories; Lead; Lipocytes; Lymphoid; Lymphopoiesis; Maintenance; Maintenances; Mammals, Mice; Mature B-Cell; Mature B-Lymphocyte; Mature Lipocyte; Mature fat cell; Mediating; Methods; Mice; Modification; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutate; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Nucleosomes; Pb element; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Properdin Factor B; Protein Binding; Protein Dimerization; Protein Motifs, DNA-Binding; Proteins; Public Health; Receptors, Antigen, B-Cell; Recruitment Activity; Regulator Genes; Role; Single Crystal Diffraction; Site; Structure; Targetings, Gene; Therapeutic Intervention; Tissues; Transcription Activation; Transcriptional Activation; Transcriptional Regulatory Elements; Up-Regulation; Vertebrate Animals; Vertebrates; Work; X Ray Crystallographies; X-Ray Crystallography; Zinc; Zn element; aminoacid; base; cell type; chromatin remodeling; demethylation; disease/disorder; fly; gene product; heavy metal Pb; heavy metal lead; helix loop helix; helix turn helix; in vivo; insight; intervention therapy; lymphocytopoiesis; neuronal; novel; progenitor; protein protein interaction; public health medicine (field); public health relevance; recruit; regulatory gene; social role; three dimensional structure; trans acting element; transcription factor; vertebrata",Structural Studies of the Early B-cell Factor (EBF)," Project Narrative  The work is relevant to the public health, because it will lead to a better understanding of how genes are regulated and may be manipulated as part of future therapies. Specifically, many diseases are the result of incorrect gene expression, and the ability to reverse the epigenetic codes that cause gene inactivity, such as DNA methylation, will provide promising approaches for therapeutic intervention. However, to achieve such therapies, it will be necessary to understand at a molecular level how a transcription factor such as EBF initiates transcriptional activity of lymphoid genes through inducing DNA demethylation of the mb-1 promoter.",75177,CMIA,Cellular and Molecular Immunology - A Study Section,,2,227254,
7762695,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI076695-02,,NIAID:194906;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SCHIFFERLI, DIETER M.;",1949888;,5R21AI076695,02/15/2009,01/31/2011,"2-Hydroxy-N,N,N-trimethylethanaminium; ATGN; Adhesins, Bacterial; Adhesions; Adhesives; Aerosols; Animals, Domestic; Antibiotic Agents; Antibiotic Drugs; Antibiotic Therapy; Antibiotic Treatment; Antibiotics; Antibodies; Antigenic Determinants; Antigens; Aphaniptera; Aspiration, Respiratory; Attenuated; Avidity; B blood cells; B-Cells; B-Lymphocytes; Bacteria; Bacterial Adhesins; Bacterial Adhesion; Binding; Binding (Molecular Function); Binding Determinants; Bite; Bordetella pertussis; Bordetella pertussis Bacterium; Breathing; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Categories; Cell Adhesion; Cell membrane; Cellular Adhesion; Choline; Choline Glycerophospholipids; Choline Phosphoglycerides; Containment; Cytoplasmic Membrane; Data; Development; Disease; Disease Outbreaks; Disease Progression; Disorder; Domestic Animals; Drug resistant bacterium; Drugs; Engineering; Engineerings; Epithelial Cells; Epitopes; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Exposure to; FDA approved; Fe element; Fleas; Fluoroquinolones; Future; Generations; Genetics-Mutagenesis; Glycolipids; Goals; Haemophilus pertussis; Hemagglutinin; Human; Human, General; Immune response; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; In Vitro; Incentives; Individual; Infection; Inhalation; Inhaling; Inspiration, Respiratory; Iron; LcrV protein; LcrV protein, Yersinia pestis; Lecithin; Link; Lipids; Lung; Mammals, Mice; Mammals, Primates; Man (Taxonomy); Man, Modern; Mediating; Medication; Membrane Proteins; Membrane-Associated Proteins; Mice; Miscellaneous Antibiotic; Modeling; Molecular Biology, Mutagenesis; Molecular Interaction; Murine; Mus; Mutagenesis; Mutagenesis, Site-Directed; Nature; Outbreaks; Pasteurella pestis; Pathogenesis; Pathogenicity; Pathogenicity Factors; Pertussis; Pertussis Vaccine; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatidylcholines; Plague; Plague Vaccine; Plasma Membrane; Pneumonia; Pneumonic Plague; Pneumonitis; Prevention Measures; Primates; Property; Property, LOINC Axis 2; Prophylactic treatment; Prophylaxis; Proteins; Protocol; Protocols documentation; Pulmonary Body System; Pulmonary Inflammation; Pulmonary Organ System; Relative; Relative (related person); Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Role; Sensitization, Immunologic; Sensitization, Immunological; Siphonaptera; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Structure; Subunit Vaccines; Surface; Surface Proteins; T-Cells; T-Lymphocyte; Targeted DNA Modification; Targeted Modification; Tetanus; Therapeutic; Therapeutic Agents; Therapeutic Studies; Therapy Research; Thymus-Dependent Lymphocytes; Tracts, Respiratory; V antigen (plague virulence); V antigen, Yersinia pestis; Vaccinated; Vaccination; Vaccines; Vaccines, Subunit; Virginia; Virulence; Virulence Factors; Virulent; Whooping Cough; Y. pestis; Y.pestis; Yersinia pestis; Yersinia pestis V antigen; Yersinia pestis disease; adhesin; analog; anti-microbial; antigen V (YP); antimicrobial; base; clostridial tetanus; combat; design; designing; disease/disorder; domesticated animal; drug resistant bacteria; drug/agent; experiment; experimental research; experimental study; extracellular; fimbria; gene product; host response; immunogen; immunogenic; immunoresponse; improved; in vivo; incentive; inducement; inhibitor; inhibitor/antagonist; inspiration; low calcium response locus protein V, Yersinia pestis; mouse model; mutant; novel; pathogen; pertactin; plague virulence antigen W; plasmalemma; prevent; preventing; public health relevance; pulmonary; research study; respiratory tract; response; social role; success; surfactant; therapeutic development; thymus derived lymphocyte; treatment of bacterial diseases; treatment of bacterial infectious disease; vaccine development","The Psa fimbriae of Yersinia pestis, an adhesin with protective immunogenic prope"," This proposal's first goal is to determine the use of a Yersinia pestis surface structure, the Psa fimbriae, as a protective immunogen against plague. A second goal is to characterize the use of inhibitors of Psa, Psa acting as a virulence factor by supporting bacterial colonization of the host and disease progression. The result of these studies will provide a useful basis for future development of vaccines and drugs that support traditional antibiotic therapy.",76695,ZRG1,Special Emphasis Panel,,2,194906,
7759164,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI076721-02,,NIAID:180675;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHARLESTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"WESTWATER, CAROLINE ;",6411158;,5R21AI076721,02/01/2009,01/31/2011,"Accounting; Activation, Gene; Alimentary Canal; Antifungal Agents; Antifungal Drug; Biology; Body Tissues; C. albicans; C.albicans; Candida; Candida albicans; Candida glabrata; Candidiasis; Candidosis; Cells; Characteristics; Chromatin; Data; Defect; Diagnosis; Digestive Tract; Disease; Disorder; Disseminated candidiasis; Disseminated candidosis; Emergent Technologies; Emerging Technologies; Esteroproteases; Expression Profiling; Expression Signature; Fungicides, Therapeutic; Fungus Diseases; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Activation; Gene Expression; Gene Expression Profile; Generalized Growth; Genes; Goals; Growth; Health; Health Care Costs; Health Costs; Healthcare Costs; Human; Human, General; Immune response; In Vitro; Incidence; Infection; Kidney; Knock-out; Knockout; Knowledge; Laboratories; Life; Life Style; Lifestyle; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Molecular; Molecular Fingerprinting; Molecular Profiling; Monilia; Moniliasis; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Mycoses; Nature; Pathogenicity; Pathogenicity Factors; Pattern; Peptidases; Peptide Hydrolases; Process; Production; Proteases; Proteinases; Proteolytic Enzymes; RT-PCR; RTPCR; Regulation; Relative; Relative (related person); Resistance; Reverse Transcriptase Polymerase Chain Reaction; Role; S cerevisiae; Saccharomyces cerevisiae; Sampling; Screening procedure; Site; Staging; Stomach; Stomach Content; Systemic candida; Systemic candida infections; Systemic candidiasis; Systemic infection; T-Cells; T-Lymphocyte; Technology; Testing; Therapeutic Intervention; Thymus-Dependent Lymphocytes; Time; Tissue Growth; Tissues; Torulopsis glabrata; Transcript; Transgenic Organisms; Triazoles; United States; Urinary System, Kidney; Virulence; Virulence Factors; Yeast, Baker's; Yeast, Brewer's; alimentary tract; anti-fungal; antifungals; base; clinical significance; clinically significant; digestive canal; disease/disorder; extracellular; fungal infection; fungus infection; gastric; gene expression signature; host response; immunoresponse; improved; in vivo; insight; intervention therapy; molecuar profile; molecular signature; novel; ontogeny; pathogen; prophylactic; public health relevance; renal; resistant; reverse transcriptase PCR; screening; screenings; social role; therapeutic vaccine; thymus derived lymphocyte; transcriptome; transgenic; treatment strategy",Candida Glabrata Gene Activation During Mucosal Infection," Our findings will impact current treatment strategies by identifying virulence factors that may be targeted for prophylactic and therapeutic intervention. Such knowledge will accelerate our ability to diagnose, treat, and control the number one fungal pathogen of humans.",76721,PTHE,Pathogenic Eukaryotes Study Section,,2,180675,
7764726,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI078240-02,,NIAID:183247;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,CHEMISTRY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"PORTER, MARC D (contact);SIERADZKI, KARL ;SIPERKO, LORRAINE ;",8339229 (contact);8915316;8917332;,5R21AI078240,02/15/2009,01/31/2011,"0-11 years old; 1,2-Ethanediol; 2-Hydroxyethanol; ATGN; Abscission; Accounting; Acids; Address; Adhesions; Adsorption; Aerosols; Affinity; Aged 65 and Over; Alloys; Alumina; Aluminum Oxide; Aluminum oxide (Al2O3); Analytical Chemistry; Antibodies; Antigens; Applications Grants; Arbovirus, Group B; Area; Arizona; Armed Forces Personnel; Arthropoda; Arthropods; Aspiration, Respiratory; Assay; Au element; Back; Benchmarking; Best Practice Analysis; Binding; Binding (Molecular Function); Bioassay; Biocide; Biologic Assays; Biological; Biological Assay; Biological Terrorism; Biomedical Engineering; Bioterrorism; Blood Serum; Breathing; CDC; Caliber; Calicivirus; Calicivirus, Feline; Caprine Species; Capsid; Categories; Cats; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Chemical Engineering; Chemistry; Chemistry, Analytic; Chemistry, Analytical; Child; Child Youth; Children (0-21); Clinical; Communicable Diseases; Communicable Diseases, Emerging; Complication; Coupling; Culicidae; Data; Detection; Development; Diagnostic; Diameter; Diffusion; Digit; Digit structure; Dihydroxyethanes; Dimensions; Disasters; Disease; Disease Marker; Disease Outbreaks; Disorder; Domestic Cats; Dorsum; Drops; EPA; Effectiveness; Egypt 101 virus; Elderly; Elderly, over 65; Electrolytes; Emerging Communicable Diseases; Engineering; Engineerings; Environmental Health; Environmental Health Science; Environmental Protection Agency; Environmental Protection Agency (U.S.); Epidemic; Esters; Ethanediols; Ethene Homopolymers; Ethylene Glycols; Ethylene Homopolymers; Ethylene Polymers; Event; Excision; Extirpation; Face; Feline Calicivirus; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Figs; Figs - dietary; Film; Flavivirus; Fluorescence; Food; Friction; Future; Goat; Gold; Grant Proposals; Grants, Applications; Guidelines; HCV; Health; Heating; Hepatitis A; Hepatitis C virus; Hepatitis, Infectious; Hepatitus C; Hour; Housing; Human; Human Resources; Human, Child; Human, General; Hydrogen Oxide; Immersion; Immersion Investigative Technique; Immunoassay; Individual; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Diseases, Emerging; Infectious Disorder; Ingestion; Inhalation; Inhaling; Inspiration, Respiratory; International; Investigation; Ixodida; Label; Laboratories; Latex Particles; Length; Life; Ligaments; Ligature; Link; Mammals, Cats; Mammals, Goats; Man (Taxonomy); Man, Modern; Manpower; Measurement; Measures; Membrane; Mercaptans; Mercapto Compounds; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Military; Military Personnel; Moab, Clinical Treatment; Modeling; Modification; Molecular Interaction; Monitor; Monoclonal Antibodies; Monoethylene Glycol; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mosquitoes; NIH; National Institutes of Health; National Institutes of Health (U.S.); Norovirus; Norwalk-like Viruses; Oligo; Oligonucleotides; Optics; Outbreaks; Particles, Latex; Parvovirus, Porcine; Pathway interactions; Performance; Phase; Phosphate Buffer; Planets; Polyethylenes; Polymers; Polysiloxane; Porcine Parvovirus; Porosity; Preparation; Pressure; Pressure- physical agent; Prevention; Procedures; Process; Programs (PT); Programs [Publication Type]; Proteins; Protocol; Protocols documentation; Public Health; Quality Control; R01 Mechanism; R01 Program; RPG; Radial; Reaction; Reading; Regulation; Removal; Reporting; Reproducibility; Research; Research Design; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Rest; Rewards; Risk; Role; Rotation; Route; S-1; S-1 Antimetabolite agent; Safety; Saline; Saline Solution; Sampling; Schools; Science of Chemistry; Scientist; Senior Scientist; Serum; Sewage; Siloxanes; Simulate; Solid; Solutions; Source; Specific qualifier value; Specified; Speed; Speed (motion); Staging; Structure; Study Type; Sulfhydryl Compounds; Surface; Surgical Removal; System; System, LOINC Axis 4; Tars; Techniques; Teleconferences; Testing; Thick; Thickness; Thiols; Ticks; Time; Transistors; Translating; Translatings; Transmission; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States Environmental Protection Agency; United States National Institutes of Health; Universities; Upper Respiratory Infections; Upper Respiratory Tract Infection; Urbanization; Utah; Viral; Viral Gastroenteritis; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virion; Virus; Virus Particle; Viruses, General; Viscosity; WNV; Water; Water Supply; West Nile; West Nile virus; Work; Yellow Fever; advanced age; analog; antigen antibody binding; base; bioengineering; bioengineering/biomedical engineering; children; coat (nonenveloped virus); cross reactivity; design; designing; disease/disorder; drinking water; elders; ethylene glycol; expectation; experience; experiment; experimental research; experimental study; facial; fiberglass; fluid flow; food monitoring; food supply monitoring; food supply surveillance; food surveillance; gene product; geriatric; glass fibers; immunogen; improved; innovate; innovation; innovative; inspiration; interest; kinematics; language translation; late life; later life; light scattering; meetings; member; membrane structure; meter; milliliter; monolayer; nano meter scale; nano meter sized; nano particle; nano scale; nano wire; nanometer scale; nanometer sized; nanoparticle; nanoscale; nanowire; older adult; older person; pathogen; pathway; personnel; pressure; prevent; preventing; programs; public health medicine (field); public health relevance; quality assurance; research study; resection; response; self assembly; senior citizen; sensor; small molecule; social role; stem; study design; sulfhydryl group; tool; transmission process; vector; virus protein; water treatment; youngster",Nanoporous Gold: Extractive Substrate for High-Speed Ultrasensitive Bioassays," Nanoporous Gold: Extractive Substrate for High-Speed Ultrasensitive Bioassays Project Narrative This grant proposal seeks to redefine the speed of heterogeneous immunoassays by exploring the potential of nanoporous gold (NPG) membranes to function as flow through capture substrates for the rapid, efficient and selective concentration of nanometrically-sized pathogens (e.g., viruses and proteins). The basis for this strategy rests with: (1) the predicted improvements in the mass transfer rates, and thus the binding rates, for both the capture and labeling steps that may be realized by flow through a nanoporous material; and (2) the high sensitivity of a readout technique that uses modified gold nanoparticles and surface enhanced Raman scattering (SERS). To carry out the above tasks, we have assembled a team of scientists and engineers from the University of Utah Departments of Chemistry, Chemical Engineering, and Bioengineering, and from the Arizona State University School of Materials.",78240,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,2,183247,
7761781,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI078365-02,,NIAID:185625;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PHYSIOLOGY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"ZHANG, LI ;",2280239;,5R21AI078365,02/01/2009,01/31/2011,"APC; ATGN; Adoptive Transfer; Affect; Antibodies, Blocking; Antigen-Presenting Cells; Antigens; Area; Assay; Atrophic Arthritis; Autoimmune Diseases; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Bioassay; Biologic Assays; Biological Assay; Biology; Blocking Antibodies; CD11b; CD11c; CD126 Antigens; CD126 Receptor; CR3; CR3 Receptor; CR3A; CTLA-8; CTLA8; Cell Differentiation; Cell Differentiation process; Cell Function; Cell Lineage; Cell Maturation; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical Trials; Clinical Trials, Unspecified; Cytofluorometry, Flow; Cytotoxic T-Lymphocyte-Associated Antigen 8; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; Data; Dendritic Cells; Development; Differentiation Factor, B-Cell; Equilibrium; Exhibits; Extracellular Matrix, Integrins; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; GeneHomolog; Generations; Genetic; Goals; HPGF; Hepatocyte-Stimulating Factor; Homolog; Homologous Gene; Homologue; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-17; IL-17A; IL-6; IL17; IL17 Protein; IL17A; IL6 Protein; IL6 Receptors; ITGAM; ITGAM gene; ITGAX; ITGAX gene; Immune; Immune Tolerance; Immunologic Accessory Cells; Immunologic Tolerance; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunosuppressants; Immunosuppression Effect; Immunosuppressions (Physiology); Immunosuppressive Agents; Immunosuppressive Effect; In Vitro; Inflammatory Arthritis; Integrin alpha-M beta-2; Integrin alphaMbeta2; Integrins; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17 Precursor; Interleukin 6 (Interferon, Beta 2); Interleukin 6 Receptor; Interleukin-17; Interleukin-6; Leukocyte Trafficking; Light; Lymphoid; MAC-1; MAC1A; MGI-2; MO1A; Mac 1; Mac-1 Adhesive Receptor; Mac-1 Antigen; Mac-1 Receptor; Macrophage-1 Antigen; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Transgenic; Microfluorometry, Flow; Molecular; Monitor; Monocytes / Macrophages / APC; Murine; Mus; Myeloid Differentiation-Inducing Protein; Natural immunosuppression; Organ; Patients; Peripheral; Photoradiation; Plasmacytoma Growth Factor; Play; Population; Production; Rag1; Rag1 Mouse; Receptor Protein; Receptor, Complement 3; Receptor, Mo1 Antigen; Receptor, Mo1 Glycoprotein; Receptors, IL-6; Regimen; Regulatory T-Lymphocyte; Reporting; Research; Reticuloendothelial System, Thymus; Rheumatoid Arthritis; Role; Splenocyte; Structure; Subcellular Process; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; Testing; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Transgenic Mice; Treatment Efficacy; Veiled Cells; accessory cell; autoimmune disorder; balance; balance function; base; clinical applicability; clinical application; clinical investigation; design; designing; experiment; experimental research; experimental study; feeding; flow cytophotometry; immune system tolerance; immune unresponsiveness; immunogen; immunological paralysis; immunosuppression; immunosuppressive; improved; in vivo; insight; interferon beta 2; macrophage; novel; oral tolerance; prevent; preventing; public health relevance; receptor; research study; response; social role; therapeutic efficacy; therapeutically effective; thymus derived lymphocyte; transcription factor",Integrin CD11b and its role in immune suppression," Completion of this study will provide novel insights into the unique role of integrin CD11b in the development of oral tolerance by regulating the balance between Treg and Th17 differentiation. Given the strong association between Th17 cells and various autoimmune diseases in human patients, the information generated may also help us design better oral-tolerance-based regimens that can be used in clinical applications for the treatment of autoimmune diseases.",78365,TTT,"Transplantation, Tolerance, and Tumor Immunology",,2,185625,
7762252,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI078376-02,,NIAID:213469;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ORLANDO,UNITED STATES,BIOCHEMISTRY,24,150805653,US,FL,328263246,UNIVERSITY OF CENTRAL FLORIDA,"CHAKRABARTI, DEBOPAM ;",1906025;,5R21AI078376,02/01/2009,01/31/2011,"0-11 years old; Affect; Anti-Malarials; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Biodiversity; Biological Diversity; Biological Factors; Cessation of life; Chemicals; Child; Child Mortality; Child Youth; Children (0-21); Clinical Treatment; Collection; Country; Data; Death; Development; Disease; Disorder; Dose; Drug Evaluation, Preclinical; Drug Screening; Drug resistance; Drugs; Ecologic Systems; Economics; Ecosystem; Environment; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Exhibits; Factor, Biologic; Florida; Generalized Growth; Goals; Growth; Health; Human, Child; Institutes; Investigators; Killings; Lead; Life; Lytotoxicity; Malaria; Marines; Medication; Methods; Mission; Natural Products; Oceans; Outcome; Paludism; Pb element; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Plants; Plants, General; Plasmodium Infections; Plasmodium falciparum; Population; Preclinical Drug Evaluation; Prevalence; Procedures; Public Health; Rain; Research; Research Personnel; Researchers; Sampling; Source; Structure; Surface; Systems, Ecological; Testing; Therapeutic; Tissue Growth; Universities; children; coral; cytotoxicity; density; disease/disorder; drug discovery; drug resistant; drug/agent; experience; forest; heavy metal Pb; heavy metal lead; human disease; innovate; innovation; innovative; marine natural product; marine organism; meter; new therapeutics; next generation therapeutics; novel; novel therapeutic intervention; novel therapeutics; ontogeny; public health medicine (field); public health relevance; resistance to Drug; resistant strain; resistant to Drug; response; sedentary; small molecule libraries; trial regimen; trial treatment; youngster",Marine Natural Products as Antimalarials, Relevance to Public Health This project will identify novel chemical entities that can be developed into drug leads for malaria therapy.,78376,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,213469,
7761270,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI078417-03,,NIAID:192888;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"GALLUCCI, STEFANIA ;",6703890;,5R21AI078417,02/01/2009,01/31/2011,"Affect; Agonist; Animals; Apoptotic; Autoimmune Status; Autoimmunity; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding; Binding (Molecular Function); Biologic Therapy; Biological Factors; Biological Response Modifier Therapy; Biological Therapy; Body Tissues; Bone-Derived Transforming Growth Factor; C3bi; CD8; CD8B; CD8B1; CD8B1 gene; CR3; CR3 Receptor; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Class Switching; Clinical; Clinical, Transplantation, Organ; Closure by Ligation; Complement; Complement Proteins; Data; Dendritic Cells; Dendritic cell activation; Dermatoplasties; Dermatoplasty; Differentiation Factor, B-Cell; Edodekin Alfa; Experimental Models; Experimental Models, Other; Exploratory/Developmental Grant; FLR; Factor, Biologic; Failure (biologic function); Goals; Graft Rejection; Grafting Procedure; HPGF; Hepatocyte-Stimulating Factor; Heterogeneity, Population; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-12; IL-6; IL12; IL6 Protein; INFLM; ITX; Immune; Immune response; Immune system; Immunization; Immunoglobulin Class Switching; Immunologic Stimulation; Immunological Stimulation; Immunologically Directed Therapy; Immunostimulation; Immunosuppressants; Immunosuppressive Agents; Immunotherapy; In Vitro; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Integrin alpha-M beta-2; Integrin alphaMbeta2; Interleukin 6 (Interferon, Beta 2); Interleukin-12; Interleukin-6; Isotype Switching; LYT3; Lead; Ligation; Link; MGI-2; Mac 1; Mac-1 Adhesive Receptor; Mac-1 Antigen; Mac-1 Receptor; Macrophage-1 Antigen; Mammals, Mice; Mating Type Switch 3; Mediating; Mice; Milk Growth Factor; Minor Histocompatibility Antigens; Minor Histocompatibility Peptides; Moab, Clinical Treatment; Modeling; Models, Experimental; Molecular Interaction; Monoclonal Antibodies; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Myelogenous; Myeloid; Myeloid Differentiation-Inducing Protein; NKSF; Natural Killer Cell Stimulatory Factor; Natural Products; Operation; Operative Procedures; Operative Surgical Procedures; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Patients; Pb element; Plasmacytoma Growth Factor; Platelet Transforming Growth Factor; Population Heterogeneity; Procedures; Production; Progenitor Cell Transplantation; Protocol; Protocols documentation; Psoriasis; R21 Mechanism; R21 Program; Radiation; Receptor Protein; Receptor, Complement 3; Receptor, Mo1 Antigen; Receptor, Mo1 Glycoprotein; Regulatory T-Lymphocyte; Role; S cerevisiae SWI3 protein; SWI/SNF Complex Component Swi3p; SWI/SNF complex component SWI3, S cerevisiae; SWI3 protein, S cerevisiae; Sensitization, Immunologic; Sensitization, Immunological; Skin; Skin Transplantation; Skin graft; Solid; Stem Cell Transplantation; Stem cell transplant; Subcellular Process; Surgical; Surgical Interventions; Surgical Procedure; Swi3p; Switch 3; Switchings, Class; Switchings, Immunoglobulin Class; Switchings, Isotype; System; System, LOINC Axis 4; T-Cell Activation; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; TGF B; TGF-beta; TGFbeta; TYE2 protein, S cerevisiae; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Tissue Transplantation; Tissues; Transcription Factor TYE2; Transcription Regulatory Protein Swi3; Transcription Regulatory Protein Swi3p; Transforming Growth Factor beta; Transplant Rejection; Transplantation; Transplantation Rejection; Transplantation Surgery; Transplantation Tolerance; Veiled Cells; Work; YJL176C protein, S cerevisiae; allogenic skin graft; anergy; biotherapeutics; biotherapy; body system, allergic/immunologic; chemotherapy; conditioning; cytokine; diverse populations; experiment; experimental research; experimental study; failure; grafting, skin; heavy metal Pb; heavy metal lead; heterogeneous population; host response; iC3b; immune therapy; immunogenic; immunoresponse; immunosuppressive; improved; in vivo; interferon beta 2; novel; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; prevent; preventing; psoriasiform; psoriatic; psoriatiform; public health relevance; ray (radiation); receptor; research study; response; self recognition (immune); social role; success; surgery; thymus derived lymphocyte; transcription regulatory protein SWI3, S cerevisiae; transplant",Dendritic Cell Ligation of Complement Receptor 3 in Transplanation Tolerance," PROJECT NARRATIVE: We have recently discovered that the ligation of Complement Receptor 3 by a monoclonal antibody suppresses the immunogenic functions of dendritic cells. This exploratory project will test the role of this novel immunosuppressive agent in preventing and suppressing graft rejection in experimental models of solid organ transplantation. Our long-term goal is to discover biologic factors able to induce a stable tolerogenic function in dendritic cells that can be used in immunotherapy of conditions, such as transplantation and autoimmunity, in which excessive and inappropriate immune responses are causing morbidity and mortality.",78417,TTT,"Transplantation, Tolerance, and Tumor Immunology",,3,192888,
7760636,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI078749-02,,NIAID:187631;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"BARKER, EDWARD  (contact);TENORIO, ALLAN R;",1943878 (contact);9113367;,5R21AI078749,02/01/2009,01/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Sites; Affect; Autologous; Binding Proteins; Blast Transformation; Blastogenesis; Blood Cells; Body Tissues; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; Cell surface; Cell-Mediated Cytolysis; Cell-Mediated Lympholysis; CellLine; Cells; Cellular Cytotoxicity; Cellular Function; Cellular Physiology; Cellular Process; Co-Stimulator; Costimulator; Cytofluorometry, Flow; Cytotoxic cell; Cytotoxicity, Immunologic; Data; Detection; Development; Dysfunction; Edodekin Alfa; Effector Cell; Environment; Epidermal Thymocyte Activating Factor; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Functional disorder; HIV; HIV-1; HIV-2; HIV-I; HIV-II; HIV1; HIV2; HL-A Antigens; HLA Antigens; HTLV-III; HTLV-IV; Hand; Histocompatibility; Human Immunodeficiency Viruses; Human Leukocyte Antigens; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type IV; Human immunodeficiency virus 1; Human immunodeficiency virus 2; IL-12; IL-2; IL12; IL2; IL2 Protein; Immune; Immune system; Immunodeficiency Virus Type 1, Human; Immunodeficiency Virus Type 2, Human; Individual; Inguinal Lymph Node; Inguinal lymph node group; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-12; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; K lymphocyte; Killings; LAV-2; LAV-HTLV-III; Lead; Leukocyte Antigens; Ligand Binding; Ligand Binding Protein; Ligands; Lymph node proper; Lymphadenopathy-Associated Virus; Lymphoblast Transformation; Lymphocyte; Lymphocyte Activation; Lymphocyte Cytotoxicity; Lymphocyte Mitogenic Factor; Lymphocyte Stimulation; Lymphocyte Transformation; Lymphocytic; Lymphocytotoxicity; Lymphoid; Lytotoxicity; Mediating; Microfluorometry, Flow; Mitogenic Factor; NK Cell Activation; NK Cells; NKSF; NTB-A; Natural Killer Cell Activation; Natural Killer Cell Stimulatory Factor; Natural Killer Cells; Pb element; Peripheral Blood Cell; Physiopathology; Population; Predisposition; Production; Receptor Activation; Receptor Protein; Resistance; Reticuloendothelial System, Lymph Node; Signal Transduction; Signal Transduction Systems; Signaling; Site; Sites, Active; Subcellular Process; Surface; Susceptibility; T cell growth factor; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; Testing; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Tissue Compatibility; Tissues; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Viremia; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Virus-HIV; Viruses, General; biological signal transduction; body system, allergic/immunologic; cell killing; cell mediated cytotoxicity; cultured cell line; cytokine; cytotoxic; cytotoxicity; expectation; flow cytophotometry; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; insight; lymph cell; lymph gland; lymph nodes; organ system, allergic/immunologic; pathophysiology; peripheral blood; public health relevance; receptor; resistant; response; thymus derived lymphocyte; treatment strategy; viraemia; viral infection; viral sepsis; virus infection; virus multiplication; virus protein; virusemia",HIV Evasion of NK Cells in Lymph Nodes," This project will determine how HIV evades immune cells called natural killer cells in the lymph nodes, which is a major site for productive HIV infection. The results from this study will provide insights on the mechanisms by which HIV avoids detection and destruction by the immune system. These insights will point the way towards treatment strategies that will enhance the immune system's ability to control HIV.",78749,AIP,AIDS Immunology and Pathogenesis Study Section,,2,187631,
7770886,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI079251-02,,NIAID:222750;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"ZIMMERMANN, NIVES ;",7843740;,5R21AI079251,02/15/2009,01/31/2011,"3'5'-cyclic ester of AMP; Acidity; Acidophilic Leukocyte; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; Allergens; Allergic; Allergic Disease; Allergic inflammation; Apoptosis; Apoptosis Pathway; Applications Grants; Asthma; Biochemical; Blood Eosinophil; Blood leukocyte; Bronchial Asthma; Bronchial Constriction; Bronchoconstriction; Cancers; Causality; Cell Death; Cell Death, Programmed; Clinical Research; Clinical Study; Coughing; Cyclic AMP; Cytoplasmic Granules; Data; Development; Disease; Disease Outcome; Disorder; Dysfunction; Environment; Environmental Factor; Environmental Risk Factor; Eosinophilia; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Etiology; Functional disorder; Future; Goals; Grant Proposals; Grants, Applications; H+ element; Human; Human, General; Hydrogen Ions; Individual; Leukocytes; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Marrow leukocyte; Measurement; Measures; Mediating; Method LOINC Axis 6; Methodology; Methods; Mice; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mucous body substance; Mucus; Murine; Mus; Necrosis; Necrotic; Outcome; Parasitic infection; Pathology; Pathway interactions; Patients; Phenotype; Physiologic; Physiological; Physiopathology; Production; Property; Property, LOINC Axis 2; Protons; Receptor Protein; Reflex; Reflex action; Research; Reticuloendothelial System, Leukocytes; Role; Series; Testing; Therapeutic; Viscosity; White Blood Cells; White Cell; adenosine 3'5' monophosphate; airway epithelium infalmmation; airway inflammation; allergic airway epithelium inflammation; allergic airway inflammation; cAMP; design; designing; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; environmental risk; eosinocyte; eosinophil; eosinophilic inflammation; experiment; experimental research; experimental study; extracellular; granule; innovate; innovation; innovative; malignancy; method development; mouse model; mucous; necrocytosis; neoplasm/cancer; novel; pathophysiology; pathway; public health relevance; receptor; research study; social role; white blood cell; white blood corpuscle",Role of Acidic Environment in Eosinophilic Inflammation," While eosinophils are a rare type of white blood cells in healthy individuals, they accumulate in large numbers in a spectrum of eosinophil-mediated diseases, including asthma, leading to significant morbidity and mortality. This grant application will research the role of acidic environment, that is present in the airways of patients with asthma, on eosinophil viability and function, and ultimately disease outcomes.",79251,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,2,222750,
7768508,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI079364-02,,NIAID:223493;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SALT LAKE CITY,UNITED STATES,DERMATOLOGY,02,009095365,US,UT,84112,UNIVERSITY OF UTAH,"GLEICH, GERALD J;WAGNER, LORI A (contact);",1868248;7839007 (contact);,5R21AI079364,02/15/2009,01/31/2011,"Acidophilic Leukocyte; Allergic Disease; Amino Acid Sequence; Apoptosis Response Protein; Asthma; Atopic Dermatitis; B Cell Differentiation Factor I; B cell growth factor 2; B-Cell Growth Factor-II; BCGF-II; BCGF2; BCGF2 (B cell growth factor 2); Blood Eosinophil; Blood Precursor Cell; Blood leukocyte; Blotting, Western; Body Tissues; Bone Marrow; Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; Bronchial Asthma; CD34; CD34 gene; Cell Communication and Signaling; Cell Signaling; Cell/Tissue, Immunohistochemistry; Cells; Cellulose, methyl ether; Chronic; Citrucel; Dermatitis, Atopic; Development; Disease; Disorder; Drugs; EDF; Eczema, Atopic; Eo-CSF; Eosinophil Differentiation Factor; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Event; Gene Transcription; Genes; Genetic Transcription; Grant; HPCA1; Hematopoietic stem cells; Hives; Hypothetical Protein; IHC; IL-5; IL5; IgA enhancing factor; Immune; Immunity; Immunohistochemistry; Immunohistochemistry Staining Method; Integral Membrane Protein; Interleukin 5 (Colony-Stimulating Factor, Eosinophil); Interleukin 5 Precursor; Interleukin-5; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Leukocytes; Location; Marrow Eosinophil; Marrow leukocyte; Mass Spectrum; Mass Spectrum Analysis; Medication; Messenger RNA; Methyl Cellulose; Methylcellulose; Microscopy; Moab, Clinical Treatment; Molecular Biology, Protein Sequencing; Monoclonal Antibodies; Morphology; Names; Neurodermatitis, Atopic; Neurodermatitis, Disseminated; PAWR; PAWR protein; PRKC, Apoptosis, WT1, Regulator; Peptide Sequence Determination; Pharmaceutic Preparations; Pharmaceutical Preparations; Photometry/Spectrum Analysis, Mass; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Production; Progenitor Cells, Hematopoietic; Prostate Apoptosis Response Protein 4; Protein Sequencing; Protein Structure, Primary; Proteins; Quantitative Microscopy; Quelling; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNAi; RT-PCR; RTPCR; Reaction; Research; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Leukocytes; Reverse Transcriptase Polymerase Chain Reaction; Ribosomes; Role; Saccharose; Sedimentation process; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sucrose; T cell replacing factor; T-Cell Replacing Factor; Time; Tissues; Transcript; Transcription; Transcription, Genetic; Transcriptional Repressor PAR4; Translating; Translatings; Transmembrane Protein; Urticaria; WT1-Interacting Protein; Western Blotting; Western Blottings; Western Immunoblotting; White Blood Cells; White Cell; allergic dermatitis; allergic eczema; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; biological signal transduction; density; disease/disorder; drug/agent; eosinocyte; eosinophil; gene product; language translation; mRNA; mRNA Expression; novel; par-4 protein; polyclonal antibody; protein blotting; protein sequence; public health relevance; reverse transcriptase PCR; sedimentation; social role; white blood cell; white blood corpuscle",TMEM103 in Eosinophil Development," Eosinophils are leukocytes associated with asthma and allergic diseases. This project explores the role of TMEM103, a novel protein, in eosinophils.",79364,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,2,223493,
7764791,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI079370-02,,NIAID:241313;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,DENTISTRY,08,604483045,US,MA,021182340,BOSTON UNIVERSITY MEDICAL CAMPUS,"TANG, XIAOREN ;",7615180;,5R21AI079370,02/05/2009,01/31/2011,"Address; Antioncogene Protein p53; Assay; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atrophic Arthritis; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Blood Vessels; Blood granulocytic cell; Blood leukocyte; Blood monocyte; Body Tissues; CCL2; CCL2 gene; Cachectin; Cachectin-Tumor Necrosis Factor; Cancer Induction; Cancers; Cell Culture Techniques; Cells; Cellular Tumor Antigen P53; Chronic; Chronic Disease; Chronic Illness; Combining Site; Complex; Crohn's disease; Crohn's disorder; Cytokine Gene; DIF; DNA; DNA-Binding Proteins; DNase-I Footprinting; Data; Defense Mechanisms; Deoxyribonucleic Acid; Development; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Differentiation Factor, B-Cell; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; EMSA; Eicosanoids; Enteritis, Granulomatous; GDCF-2; GDCF-2 HC11; Gene Expression; Genes; Genes, p53; Genetic Alteration; Genetic Change; Genetic defect; Granular Leukocytes; Granulocytic cell; HC11; HPGF; Hepatocyte-Stimulating Factor; Human; Human, General; Hybridoma Growth Factor; IDD; IDDM; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; INFLM; Immune; In Vitro; Inflammation; Inflammatory; Inflammatory Arthritis; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Injection of therapeutic agent; Injections; Injury; Insulin-Dependent Diabetes Mellitus; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; LPS; Laboratories; Lead; Length; Leukocytes; Light; Link; Lipopolysaccharides; Lymphocyte-Stimulating Hormone; Lymphocytes, Null; MCAF; MCP-1; MCP1; MGC9434; MGI-2; Macrophage Cell Factor; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuscripts; Marrow leukocyte; Marrow monocyte; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Mice; Murine; Mus; Mutate; Mutation; Myeloid Differentiation-Inducing Protein; Necrosis; Necrotic; Null Cells; Null Lymphocytes; Oncoprotein p53; P53; Parodontosis; Pattern; Pb element; Peptides; Periodontal Diseases; Phosphoprotein P53; Phosphoprotein pp53; Photoradiation; Plasmacytoma Growth Factor; Play; Process; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein TP53; Protein p53; Reactive Site; Regulation; Reticuloendothelial System, Leukocytes; Rheumatoid Arthritis; Role; SCYA2; SMC-CF; Sepsis; Series; Site; Structure; T Helper Factor; T1 diabetes; T1D; T1DM; TNF; TNF A; TNF Alpha; TNF gene; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2; TNFSF2 protein, human; TP53; TP53 gene; TRP53; Techniques; Testing; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transfection; Tumor Necrosis Factor; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Tumor Protein p53; Tumor Protein p53 Gene; Type 1 diabetes; Ulcerated Colitis; Ulcerative Colitis; VEGFs; Vascular Endothelial Growth Factors; Vegf; White Blood Cells; White Cell; Work; animal data; atheromatosis; atherosclerotic vascular disease; bloodstream infection; carcinogenesis; chronic disease/disorder; chronic disorder; cytokine; design; designing; disease/disorder; eleocolitis; genome mutation; granulocyte; granulomatous enterocolitis; heavy metal Pb; heavy metal lead; human TNF protein; human disease; in vitro testing; in vivo; inhibitor; inhibitor/antagonist; insulin dependent diabetes; interferon beta 2; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; lymphocyte activating factor; macrophage; malignancy; monocyte; mutant; neoplasm/cancer; novel; novel therapeutic intervention; p53 Antigen; p53 Tumor Suppressor; periodontal disorder; periodontium disease; periodontium disorder; psychological defense mechanism; public health relevance; reactive oxygen intermediate; regional enteritis; repair; repaired; response; serial analysis of gene expression; social role; synthetic peptide; transcription factor; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; type I diabetes; vascular; white blood cell; white blood corpuscle",Role of P53 in LITAF Process," A common component in various chronic diseases and cancer development is the inflammatory process. The present work proposes to investigate a novel link between p53 and inflammation, and to test a potentially novel interventional approach to control p53-associated inflammatory processes. In addition, since loss or inactivation of p53 plays a key role in cancer development, understanding a link between p53 and the inflammatory process might shed light onto the established but incompletely understood connection between chronic inflammation and carcinogenesis.",79370,III,Innate Immunity and Inflammation Study Section,,2,241313,
7777381,R21,AI,5,,03/01/2010,02/28/2011,PA-06-181,5R21AI079429-02,,NIAID:191070;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLLEGE PARK,UNITED STATES,SOCIAL SCIENCES,05,790934285,US,MD,207425141,UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS,"JACOBS-LORENA, MARCELO ;ST LEGER, RAYMOND J (contact);",1895745;2108382 (contact);,5R21AI079429,03/01/2009,02/28/2011,"21+ years old; Adult; Anopheles gambiae; Anti-Malarials; Antibody Fragments; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Area; Attenuated; Binding; Binding (Molecular Function); Biological Models; Biology; Culicidae; Dengue; Dengue Fever; Dose; Encephalitis, Viral; Engineering; Engineerings; Filariasis; Filarioidea Infections; Goals; Head and Neck, Salivary Glands; Human; Human, Adult; Human, General; Immune system; Immunization; Immunoglobulin Fragments; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Infectious Encephalomyelitis, Viral; Insecta; Insects; Invertebrates, Insects; Killings; Life; MCL1; MCL1 gene; Malaria; Man (Taxonomy); Man, Modern; Membrane Proteins; Membrane-Associated Proteins; Model System; Models, Biologic; Molecular Interaction; Mortality; Mortality Vital Statistics; Mosquito-borne disease; Mosquito-borne infectious disease; Mosquitoes; Myeloid Cell Leukemia Sequence 1 Gene; Outcome; Paludism; Parasites; Peptides; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Population; Prevalence; Probability; Proteins; Recombinants; Reproduction spores; Resistance; Salivary Glands; Scorpions; Screening procedure; Sensitization, Immunologic; Sensitization, Immunological; Spores; Sporozoites; Surface Proteins; System; System, LOINC Axis 4; Testing; Time; Toxin; Transgenic Organisms; Transmission; Vector-borne disease; Vector-borne infectious disease; Vector-transmitted disease; Vector-transmitted infectious disease; Viral Encephalitis; Virulence; Yellow Fever; adult human (21+); base; body system, allergic/immunologic; breakbone fever; circumsporozoite; communicable disease transmission; design and construction; disease transmission; efficacy testing; experiment; experimental research; experimental study; fungus; gene product; human disease; hybrid gene; improved; infectious disease transmission; mutant; novel; organ system, allergic/immunologic; pathogen; public health relevance; research study; resistant; response; screening; screenings; tool; transgenic; transmission process; vector",Vector biology-Using a mosquito pathogen as a delivery system for anti-malarial a," This project aims to design, construct and evaluate recombinant fungal pathogens that target adult mosquitoes and the malaria parasite. The most significant possible outcome of producing an optimized fungal pathogen will be a reduction of human disease as a result of interrupting transmission of the target parasite.",79429,VB,Vector Biology Study Section,,2,191070,
7764768,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI079629-02,,NIAID:209138;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,071037113,US,NY,100656399,ROCKEFELLER UNIVERSITY,"MACDONALD, MARGARET R;",1893007;,5R21AI079629,02/05/2009,01/31/2011,"Alpha Virus; Alphavirus; Alphavirus Infections; Animal Diseases; Animal Feed; Animal Model; Animal Models and Related Studies; Animals; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Arboviruses, Group A; Arthritis; Bacteria; Biological Terrorism; Bioterrorism; C elegans; C. elegans genome; C.elegans; Caenorhabditis elegans; Categories; Cessation of life; Chemicals; Complex; DNA; Death; Deoxyribonucleic Acid; Development; Disease; Disorder; Double-Stranded RNA; Encephalitis; Engineering; Engineerings; Epidemic; Equine; Equine Species; Equus caballus; Equus przewalskii; Exanthem; Exanthema; FLR; Failure (biologic function); Family; Fever; Future; GFP; Gene Products, RNA; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic Transcription; Genetic analyses; Genetic defect; Genetics-Mutagenesis; Genome; Goals; Green Fluorescent Proteins; Heating; Homologous Protein; Horse, Domestic; Horses; Host Factor; Host Factor Protein; Human; Human, General; Hyperthermia; Imagery; Inflammation, Brain; Insect Proteins; Integration Host Factors; Intervention; Intervention Strategies; Lead; Life Cycle; Life Cycle Stages; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Modeling; Models, Genetic; Molecular Biology, Mutagenesis; Monitor; Mutagenesis; Mutation; NIAID; National Institute of Allergy and Infectious Disease; Nematoda; Nematodes; Pb element; Play; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Homolog; ProteinHomolog; Proteins; Proteomics; Pyrexia; RNA; RNA Expression; RNA Viruses; RNA replication; RNA, Double-Stranded; RNA, Non-Polyadenylated; RNA, Viral; Rash; Replication Unit; Replicon; Research Design; Ribonucleic Acid; Role; Sindbis Virus; Skin Rash; Study Type; Symptoms; System; System, LOINC Axis 4; Techniques; Testing; Togaviridae; Togaviruses; Transcription; Transcription, Genetic; Transgenic Animals; Transgenic Organisms; Viral; Virus; Virus Replication; Viruses, General; Visualization; Work; animal food; arthritic; chikungunya; combat; disease/disorder; dsRNA; failure; febrile; febris; feeding; gene product; genetic analysis; genome mutation; genome, C elegans; genome, C. elegans; genome, C.elegans; genome, Caenorhabditis elegans; heavy metal Pb; heavy metal lead; interventional strategy; life course; member; model development; model organism; mutant; novel; pathogen; protein expression; public health relevance; replicase; roundworm; social role; study design; tool; transgenic; treatment of viral infectious disease; viral RNA; virus RNA; virus host interaction; virus multiplication",Development of a genetically tractable nematode model of alphavirus infection," Project Narrative Viruses in the Alphavirus genus cause diseases ranging from fever, rash and arthritis, to encephalitis and death, yet to date no specific therapies exist. This study will develop a small animal (nematode) model of Alphavirus infection, which will be used to take a genetic approach to identify host factors that are required for viral replication. Understanding the virus-host interaction in greater detail may lead to the development of specific therapies.",79629,ZRG1,Special Emphasis Panel,,2,209138,
7767005,R21,AI,5,,03/01/2010,02/28/2011,PA-06-181,5R21AI080279-02,,NIAID:148240;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,VANCOUVER,CANADA,,,251949962,CA,BC,V6T 1Z3,UNIVERSITY OF BRITISH COLUMBIA,"KRONSTAD, JAMES W;",1932947;,5R21AI080279,03/01/2009,02/28/2011,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Antifungal Agents; Antifungal Drug; Antifungal Therapy; Antirejection Therapy; Aspiration, Respiratory; Breathing; CAPS; CNP; Capsules; Cells; Cerebromeningitis; Cerebrospinal Fluid; Cerebrum; Chromosome 13; Chromosome 4; Chromosomes; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 4; Clinical; Copy Number Polymorphism; Cryptococcosis; Cryptococcus neoformans; Cryptococcus neoformans infection; DNA; Deoxyribonucleic Acid; Disease; Disease Outcome; Disorder; Drug resistance; Encephalomeningitis; Environment; Frequencies (time pattern); Frequency; Fungicides, Therapeutic; Fungus Diseases; Generalized Growth; Genetic; Genome; Genomics; Goals; Growth; HIV; HTLV-III; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immune response; Immune system; Immunocompetent; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunologic Deficiency Syndrome, Acquired; Immunosuppressed Host; Immunosuppressive Therapy; Incidence; Infection; Infection by Cryptococcus neoformans; Inhalation; Inhaling; Inspiration, Respiratory; LAV-HTLV-III; Life; Link; Literature; Lymphadenopathy-Associated Virus; Mammals, Mice; Man (Taxonomy); Man, Modern; Melanins; Meningitis; Meningoencephalitis; Mice; Modeling; Murine; Mus; Mycoses; Pathogenicity Factors; Patients; Phenotype; Predisposition; Process; Production; Property; Property, LOINC Axis 2; Relapse; Research; Risk; Sampling; Serotyping; Source; Susceptibility; Temperature; Testing; Therapeutic Intervention; Therapeutic immunosuppression; Therapy, Anti-Rejection; Tissue Growth; Torulosis; Treatment Failure; Variant; Variation; Virulence; Virulence Factors; Virus-HIV; Work; anti-fungal; antifungals; artificial immunosuppression; body system, allergic/immunologic; capsule (pharmacologic); combat; copy number variation; disease/disorder; drug resistant; fungal infection; fungus; fungus infection; host response; immunoresponse; immunosuppressed patient; immunosuppression; inspiration; interest; intervention therapy; mouse model; novel; ontogeny; organ system, allergic/immunologic; pathogen; prevent; preventing; public health relevance; resistance to Drug; resistant to Drug; spinal fluid; trait; treatment of fungal infectious disease",Chromosome copy number variation and AIDS-associated cryptococcosis, Project Narrative. The relevance of this project comes from the pressing need to control fungal infections in humans that have impaired immune systems due to AIDS or immunosuppressive therapy. The 40 million or more people infected with HIV are at particular risk of succumbing to fungal disease. The proposed research will specifically examine the ability of a fungal pathogen to vary its genetic make up during the infection process. Pathogen variation may contribute to persistence during infection and treatment failure.,80279,ZRG1,Special Emphasis Panel,,2,148240,
7765536,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081058-02,,NIAID:224235;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,GALVESTON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,14,800771149,US,TX,77555,UNIVERSITY OF TEXAS MEDICAL BR GALVESTON,"LEMON, STANLEY M;",1888131;,5R21AI081058,02/06/2009,01/31/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; 1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; ATRA; Adaptor Protein; Adaptor Signaling Protein; All-trans retinoic acid; Anti-Viral Response; Antiviral Agents; Antiviral Drugs; Antiviral Response; Antivirals; Archives; Body Tissues; Carcinoma of the Liver Cells; Cell Communication and Signaling; Cell Signaling; Cells; Chimp; Chimpanzee; Chronic; Chronic Hepatitis C; Chronic type C viral hepatitis; Chronic viral hepatitis C; Cirrhosis; Clinical; Conflict; Conflict (Psychology); Data; Dendritic Cells; Development; Disease; Disorder; Double-Stranded RNA; EFP; Esteroproteases; Estrogen-Responsive Finger Protein; Event; Future; Gene Expression; Genes; Genotype; Goals; HCC; HCV; HCV Chronic Infection; HCV infection; Hepatic Cancer; Hepatic Cells; Hepatic Failure; Hepatic Parenchymal Cell; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis C, Chronic; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatocyte; Hepatoma; Human; Human, General; IFN; IFN-regulatory factor 3; IRF-3 protein; IRF3; IRF3 protein, human; Imaging Procedures; Imaging Techniques; Immune; Immune response; Immune system; Immunity; Immunoglobulin Enhancer-Binding Protein; In Situ; In Vitro; Infection; Interferon Regulatory Factor 3; Interferons; Intracellular Communication and Signaling; Laboratories; Liver; Liver Cells; Liver Failure; Location; Malignant neoplasm of liver; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Microscopy; Molecular; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NANBH; NF-kB; NF-kappa B; NF-kappaB; NFKB; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Outcome; PT-NANBH; Pan; Pan Genus; Pan Species; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Pathway interactions; Patients; Pattern; Peptidases; Peptide Hydrolases; Persons; Play; Primary carcinoma of the liver cells; Proteases; Protein Cleavage; Proteinases; Proteins; Proteolysis; Proteolytic Enzymes; Q-Dot; Quantum Dots; R01 Mechanism; R01 Program; RNA, Double-Stranded; RPG; RTCA; Receptor Protein; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Retinoic Acid; Retinoic Acid Receptor; Ribavirin; Ribovirin; Role; Semiconductors; Sensitivity and Specificity; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Source; System; System, LOINC Axis 4; TLR3; TLR3 protein, human; TLR3 receptor; TRIM25; TRIM25 protein, human; Technics, Imaging; Techniques; Tissues; Toll-Like Receptor 3; Toll-like receptor 3, human; Trans Vitamin A Acid; Transcription Factor NF-kB; Tretinoin; Tretinoinum; Tribavirin; Tripartite Motif Protein TRIM25; Tripartite Motif-Containing 25; United States; Veiled Cells; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Virus; Virus Activation; Virus Diseases; Virus Induction; Virus Replication; Viruses, General; Vitamin A Acid; Z147; ZNF147; ZNF147 protein, human; Zinc Finger Protein 147; all-trans-Retinoic Acid; all-trans-Vitamin A acid; biological signal transduction; body system, allergic/immunologic; body system, hepatic; cig5 gene product; cytokine; disease/disorder; dsRNA; efp protein, human; estrogen-responsive finger protein, human; gene product; hepatitis non A non B; hepatitis nonA nonB; host response; human IRF3 protein; human TLR3 protein; human TRIM25 protein; immunoresponse; in vivo; interferon regulatory factor 3 protein, human; interferon regulatory factor-3; intrahepatic; kappa B Enhancer Binding Protein; liver cancer; macrophage; malignant liver tumor; molecular imaging; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; nuclear factor kappa beta; organ system, allergic/immunologic; organ system, hepatic; paracrine; pathogen; pathway; public health relevance; receptor; response; social role; trans-Retinoic Acid; transcription factor; tripartite motif-containing 25 protein, human; viperin; viral infection; virus infection; virus multiplication; virus protein; zinf finger protein 147, human",Intrahepatic IRF-3 and NF-kB Signaling and Interferon Responses in Hepatitis C," LAY NARRATIVE Hepatitis C virus is an increasing cause of liver-specific morbidity and mortality in the United States, and the leading infectious cause of cirrhosis, liver failure and liver cancer. Much of this derives from its ability to cause long-term persistent infections, but how the virus successfully escapes immune responses and accomplishes this is not understood. In this project, we will apply recent advances in molecular imaging techniques to directly examine the interactions of the virus with the innate immune system signaling pathways that induce interferon- mediated antiviral responses within the liver.",81058,HBPP,Hepatobiliary Pathophysiology Study Section,,2,224235,
7760641,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081066-02,,NIAID:227948;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NASHVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"BALLARD, DEAN ;",1888199;,5R21AI081066,02/01/2009,01/31/2011,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; ATP-protein phosphotransferase; Acute; Agonist; Animal Model; Animal Models and Related Studies; Antigen Receptors; Arthritis; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Cachectin Receptors; Cancers; Cell Communication and Signaling; Cell Line, Transformed; Cell Signaling; Cell model; Cell surface; Cell-Free System; Cellfree System; Cells; Cellular model; Chronic; Complex; Cytokine Receptors; DIF; Defect; Dendritic Cells; Disease; Disorder; Docking; EC 2.7; EC 2.7.2-; Engineering; Engineerings; Ensure; Extracellular Signal-Regulated Kinases; Future; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic defect; Growth; HMG-20; Health; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; High Mobility Protein 20; Host Defense; Human; Human, General; Humoral Immunities; IL-1; IL1; INFLM; Immune Globulins; Immune response; Immune system; Immunities, Humoral; Immunity; Immunoglobulins; Immunoglobulins / Antibodies; In Vitro; Infection; Inflammation; Inflammatory; Interleukin 1 Signal Transducer; Interleukin I; Interleukin-1; Intracellular Communication and Signaling; Kinases; Knock-in; Knock-in Mouse; LPS; Laboratories; Lead; Ligand Binding Protein; Ligands; Link; Lipopolysaccharides; Lupus; Lymphocyte; Lymphocyte Function; Lymphocyte-Stimulating Hormone; Lymphocytic; MAP kinase; MAPK; Macropain; Macrophage Cell Factor; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Modification; Molecular Interaction; Multicatalytic Proteinase; Murine; Mus; Mutant Strains Mice; Mutation; Pathology; Pb element; Phagocytes; Phagocytic Cell; Phenotype; Phosphotransferases; Physiologic; Physiological; Play; Point Mutation; Polyubiquitin; Polyubiquitination; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Production; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Kinase; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Proteosome; R01 Mechanism; R01 Program; RIP; RIP Protein Kinase; RIPK1; RIPK1 protein, human; RPG; Receptor Protein; Receptor Signaling; Receptor-Interacting Protein; Receptor-Interacting Serine/Threonine Kinase 1; Receptors, Antigen; Receptors, Cytokine; Regulation; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Staging; Stimulus; T Helper Factor; T-Cells; T-Lymphocyte; TLR protein; TNF; TNF A; TNF Receptor Family Protein; TNF Receptor Superfamily; TNF Receptors; TNF gene; TNF receptor-associated factor 6; TNFR; TNFSF2; TRAF-6 Protein; TRAF6; Testing; Therapeutic Intervention; Thymus-Dependent Lymphocytes; Tissue Growth; Toll-like receptors; Transducers; Transformed Cell Line; Transmission; Transphosphorylases; Tumor Necrosis Factor Gene; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor Receptor Family; Tumor Necrosis Factor Receptor Superfamily; Ubiquitilation; Ubiquitin; Ubiquitin, poly-; Ubiquitination; Ubiquitinoylation; Veiled Cells; amebocyte; antibody-based immunity; apoptosis in lymphocytes; arthritic; base; biological signal transduction; body system, allergic/immunologic; cell transformation; cytokine; disease/disorder; experiment; experimental research; experimental study; gene product; genome mutation; glycogen synthase a kinase; heavy metal Pb; heavy metal lead; host response; human RIPK1 protein; hydroxyalkyl protein kinase; immunoresponse; in vivo; in vivo Model; inhibitor; inhibitor/antagonist; intervention therapy; lymph cell; lymphocyte activating factor; lymphocyte apoptosis; macrophage; malignancy; meetings; member; microbial; migration; model organism; mouse mutant; multicatalytic endopeptidase complex; mutant; neoplasm/cancer; novel; ontogeny; organ system, allergic/immunologic; pathogen; phosphorylase b kinase kinase; protein function; public health relevance; receptor; research study; response; sensor; social role; thymus derived lymphocyte; transcription factor; transformed cells; transmission process; ubiquination; ubiquitin conjugation",In Vivo Function of NEMO As a Sensor of K63-Linked Polyubiquitination," Public health relevance: Signal transmission within cells of the immune system coordinates the host defense against microbial pathogens and must be tightly regulated to avoid chronic inflammation. Recent in vitro experiments suggest that signal transmission involves the interaction of intracellular proteins with ubiquitin chains. New in vivo studies are proposed to investigate the physiologic function of a specific ubiquitin-binding protein, the relevance of this ubiquitin sensing mechanism to human health, and the potential for treating inflammation-based disease at the level of ubiquitination.",81066,CMIA,Cellular and Molecular Immunology - A Study Section,,2,227948,
7766212,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081068-02,,NIAID:233145;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SYRACUSE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,25,058889106,US,NY,13210,UPSTATE MEDICAL UNIVERSITY,"HAYES, SANDRA MARIE;",8550995;,5R21AI081068,02/15/2009,01/31/2011,"ATGN; ATP[{..}]protein-tyrosine O-phosphotransferase; Address; Affect; Antigen Receptors; Antigens; Area; Biological; CD3; CD3 Antigens; CD3 Complex; CD3 molecule; Cell Communication and Signaling; Cell Growth in Number; Cell Lineage; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Cellular biology; Cloning; Complex; Coupled; Defect; Development; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Employee Strikes; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Family; Family member; Foundations; Future; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Goals; HEK3; Immune; Immune response; Immunity; Infection; Intracellular Communication and Signaling; Investigation; Kinases; Knowledge; Learning; Lipids; Lymphocyte; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocyte-Specific Protein-Tyrosine Kinase; Lymphocyte-Specific p56LCK Tyrosine Protein Kinase; Lymphocytic; Lymphoid; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mature T-Cell; Mature T-Lymphocyte; Measures; Mediating; Membrane; Mice; Modeling; Modification; Murine; Mus; OKT3 antigen; PTK; Pattern; Phosphorylation; Phosphotransferases; Play; Population; Process; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Phosphorylation; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase p56(lck); Protein-Tyrosine Kinases, src; Proto-Oncogene Protein c-lck; Proto-Oncogene Protein lck; Proto-Oncogene Tyrosine-Protein Kinase LCK; Receptor Cell; Receptor Gene; Receptor Signaling; Receptors, Antigen; Receptors, Antigen, T-Cell; Research Proposals; Resistance; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Specificity; Strikes; Strikes, Employee; Structure; Surface; T-Cell Development; T-Cell Ontogeny; T-Cell Receptor; T-Cell Specific Protein Tyrosine Kinase; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T3 Antigens; T3 Complex; T3 molecule; Testing; Thymus-Dependent Lymphocytes; Transcript Expression Analyses; Transcript Expression Analysis; Transphosphorylases; Tumor Cell; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Vaccine Design; Wound Healing; Wound Repair; base; biological signal transduction; calcium flux; calcium mobilization; cell biology; cross-link; crosslink; dimer; experiment; experimental research; experimental study; host response; hydroxyaryl protein kinase; immunogen; immunoresponse; improved; lck Kinase; lymph cell; membrane structure; neoplastic cell; p56 lck; pathogen; programs; public health relevance; receptor coupling; release of sequestered calcium ion into cytoplasm; research study; resistant; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; stem; thymocyte; thymus derived lymphocyte; tissue repair; tumor; tyrosyl protein kinase",Role of Blk in gamma delta T cell development and function, NARRATIVE It is expected that this study will provide important information about T cells. This knowledge will aid in the design of vaccines aimed at improving resistance to tumor cells and pathogens by specifically targeting T cells.,81068,CMIB,Cellular and Molecular Immunology - B Study Section,,2,233145,
7769902,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081097-02,,NIAID:238590;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,070967955,US,WA,98109,SEATTLE BIOMEDICAL RESEARCH INSTITUTE,"GARDNER, MALCOLM JOHN;",8273335;,5R21AI081097,02/15/2009,01/31/2011,"2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))-; Abbreviations; Acyl Carrier Protein; Address; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases; Amino Acyl-tRNA Synthetases; Amino Acylation; Aminoacyl Transfer RNA Synthetase; Aminoacyl-tRNA Synthetase; Aminoacylation; Anabolism; Anti-Bacterial Agents; Anti-Malarials; Antibacterial Agents; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Antigenic Determinants; Antimalarial Agents; Antimalarial Drugs; Antimalarials; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Assay; Bacteria; Binding Determinants; Bioassay; Biochemical; Biochemical Pathway; Biologic Assays; Biological Assay; Biosynthetic Proteins; Cells; Cessation of life; Chloroquine resistance; Cytosol; Data; Death; Dependence; Doxycycline; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Therapy; Drugs; E coli; Endoplasmic Reticulum; Enzymes; Epitopes; Ergastoplasm; Escherichia coli; Exhibits; Future; GFP; GeneHomolog; Genes; Genome; Germ; Gln; Gln-tRNA; GlnRS; Glu-tRNA; Glu-tRNA Ligase; Glutamate-tRNA Ligase; Glutamates; Glutamic Acid-Specific tRNA; Glutamine; Glutamine-Specific tRNA; Glutamine-tRNA ligase; Glutamyl T RNA Synthetase; Glutamyl-tRNA Synthetase; Goals; Green Fluorescent Proteins; Homolog; Homologous Gene; Homologue; Human; Human, General; Immunofluorescence; Immunofluorescence Immunologic; Immunologic, Immunofluorescence; Intermediary Metabolism; L-Glutamate; L-Glutamate[{..}]tRNA(Glu) ligase (AMP-forming); L-Glutamine; METBL; Malaria; Mammalian Cell; Man (Taxonomy); Man, Modern; Medication; Metabolic Networks; Metabolic Processes; Metabolism; Miscellaneous Antibiotic; Molecular Genetic; Molecular Genetics; Nuclear; Operon; Ortholog; Orthologous Gene; Paludism; Parasites; Pathway interactions; Peptide Biosynthesis, Ribosomal; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Plasmodium; Plasmodium Infections; Plasmodium falciparum; Plastids; Process; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Synthesis, Ribosomal; Q. Levoglutamide; RNA, Transfer, Gln; RNA, Transfer, Glu; Reaction; Recombinant Proteins; Recombinants; Reporter; Research; Resistance; Ribonucleic acids, transfer; Route; Staging; TLC; Thin Layer Chromatography; Toxic effect; Toxicities; Transfection; Transfer RNA; Transfer RNA Synthetase; Transgenic Organisms; Translations; Triplet Codon-Amino Acid Adaptor; Vibramycin; Wheat; alpha-6-Deoxyoxytetracycline; aminoacid tRNA ligase; anti-bacterial; antibacterial; biosynthesis; chemotherapy; chloroquine resistant; clinical relevance; clinically relevant; comparative; drug/agent; genome sequencing; glutamic acid-tRNA; glutamine-tRNA; glutaminyl-tRNA; glutaminyl-tRNA synthetase; glutamyl-tRNA; inhibitor; inhibitor/antagonist; insight; markov model; novel; pathway; prevent; preventing; programs; protein complex; protein synthesis; public health relevance; resistance to chloroquine; resistant; resistant to chloroquine; tRNA; tRNA Synthetase; tRNA(Gln); tRNA(Glu); tRNA, glutamic acid-; tRNA, glutamine-; tRNAGln; tRNAGlu; transgenic; validation studies",Indirect aminoacylation in the Plasmodium apicoplast, The human malaria parasite Plasmodium falciparum causes over 300 million cases of malaria and 1.3 million deaths annually. New drugs are required to treat and prevent malaria because of resistance to existing anti- malarial drugs. This research program will characterize a novel Plasmodium biochemical pathway that we believe is essential to parasite survival and therefore a potential target for drug therapy of malaria.,81097,PTHE,Pathogenic Eukaryotes Study Section,,2,238590,
7767761,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081167-02,,NIAID:231660;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,GENETICS,01,005421136,US,IL,60637,UNIVERSITY OF CHICAGO,"STORB, URSULA B;",1868206;,5R21AI081167,02/15/2009,01/31/2011,"5'-Adenylic acid, homopolymer; Affect; Affinity; Antibodies; Autoimmune Status; Autoimmunity; B blood cells; B-Cells; B-Lymphocytes; Base Excision Repairs; Biological Function; Biological Process; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Cause; Cancer Etiology; Cancers; Cell Cycle; Cell Division Cycle; Cell Line; Cell Lines, Strains; CellLine; Cells; Chickens; Complex; Constant Region; Constant Region, Ig; Cytidine; Cytidine Aminohydrolase; Cytidine Deaminase; Cytosine Ribonucleoside; Cytosine Riboside; DNA Base Excision Repair; DNA Polymerases; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Single-Stranded; DNA, Supercoiled; DNA, Superhelical; DNA, Supertwisted; DNA-Dependent DNA Polymerases; DNA-Dependent RNA Polymerases; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerase; Deamination; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Disease; Disorder; EC 2.7.7.6; EC 2.7.7.7; Exhibits; First Gap Phase; Frequencies (time pattern); Frequency; G1 Phase; G1 period; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gap Phase 1; Gene Conversion; Gene Transcription; Genes; Genes, Ig; Genes, Immunoglobulin; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic defect; Histones; Ig Somatic Hypermutation; Immune response; Immunoglobulin Constant Region; Immunoglobulin Genes; Immunoglobulin Somatic Hypermutation; Immunoglobulin V; Immunoglobulin Variable Region; Lymphocyte; Lymphocytic; M Phase; M phase (cell cycle); MMR; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Methods; Mice; Mismatch Repair; Mitosis; Mitosis Stage; Modeling; Molecular; Murine; Mus; Mutate; Mutation; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Parents; Pattern; Phase; Poly A; Poly(rA); Polymerase; Position; Positioning Attribute; Post-Replication Mismatch Repair; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); RNA Expression; RNA Polymerases; Recruitment Activity; Repairs, Base Excision; Research; Role; Single-Stranded DNA; Site; Somatic Hypermutation, Immunoglobulin; Somatic Mutation; Superhelical DNA; System; System, LOINC Axis 4; Testing; Time; Transcript; Transcription; Transcription, Genetic; Travel; Urd; Uridine; Variable Region; Variable Region, Ig; Wild Type Mouse; antigen binding; base; cultured cell line; disease/disorder; experiment; experimental research; experimental study; gene terminator; genome mutation; host response; immunoresponse; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; interest; lymph cell; malignancy; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; pathogen; polyadenylate; public health relevance; recruit; repair; repaired; research study; response; self recognition (immune); social role; somatic hypermutation; tool; transcription termination; transition mutation",AID in somatic mutation of immunoglobulin genes," Lay Narrative This is a proposal to study the hypermutation of antibody genes. This process is beneficial, because it can result in highly specific and efficient antibodies against pathogens and cancer. However, it is also dangerous, because it can cause cancer of lymphocytes and autoimmunity.",81167,CMIA,Cellular and Molecular Immunology - A Study Section,,2,231660,
7763172,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI081235-02,,NIAID:286308;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,070967955,US,WA,98109,SEATTLE BIOMEDICAL RESEARCH INSTITUTE,"WHITE, THEODORE C.;",1876443;,5R21AI081235,02/03/2009,01/31/2011,"0-11 years old; Address; Agrobacterium tumefaciens; Animals; Area; Arthrodermataceae; Aspergillus; Athlete's Foot; Candida; Cells; Child; Child Youth; Childhood; Children (0-21); Complex; Cryptococcus; Cutaneous Fungus; DNA; Deoxyribonucleic Acid; Depressed mood; Dermatomyces; Dermatophytes; Detection; Development; Diagnosis; Diagnostic; Drugs; ESTs; Endodermophyton; Esteroproteases; Exhibits; Expressed Sequence Tags; Funding; Fungi, Filamentous; Fungus Diseases; Gene Deletion; Gene Expression; Generalized Growth; Genetics-Mutagenesis; Genotype; Goals; Growth; Head; Healthcare Systems; Human; Human, Child; Human, General; Individual; Infection; Infection prevention; Institutes; Investigators; Larva; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medication; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Modeling; Molds; Molecular; Molecular Biology, Mutagenesis; Monilia; Moths; Mutagenesis; Mycoses; NHEJ; Nail plate; Nails; Non-Homologous End Joining; Nonhomologous DNA End Joining; Pain; Painful; Pathogenicity; Patients; Peptidases; Peptide Hydrolases; Pharmaceutic Preparations; Pharmaceutical Preparations; Phenotype; Population; Prevent infection; Prevention; Prevention Measures; Prevention strategy; Preventive strategy; Prophylactic treatment; Prophylaxis; Proteases; Proteinases; Proteolytic Enzymes; Research; Research Personnel; Researchers; Resistance; Rhizobium radiobacter; Ringworm; Rodent; Rodentia; Rodentias; Route; Scalp; Scalp structure; Skin; Study models; Surface; Symptoms; Systems, Health Care; Techniques; Testing; Tinea; Tinea Capitis; Tinea Pedis; Tissue Growth; Torula; Trichophyton; Trychophyton; United States; Vaccines; Virulence; Waxes; cDNA Arrays; cDNA Microarray; children; depressed; drug/agent; economic impact; fungal infection; fungus; fungus infection; gene deletion mutation; genome sequencing; homologous recombination; improved; keratinocyte; microarray technology; novel; ontogeny; overexpression; pathogen; pediatric; public health relevance; resistant; sadness; theories; tool; youngster",A molecular toolbox for hypothesis testing in the dermatophytes," Dermatophytes are pathogenic fungi responsible for a variety of skin and nail infections, including athlete's foot and tinea capitis, a common fungal infection of the head in patients in socio- economically depressed areas. It is estimated that dermatophytes are the most common fungal infection worldwide. This proposal will develop a set of molecular tools that can be used in combination with the soon-to-be-completed genome sequences to address important questions about dermatophyte prevention, treatment and diagnosis.",81235,PTHE,Pathogenic Eukaryotes Study Section,,2,286308,
7769893,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082143-02,,NIAID:201960;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LEXINGTON,UNITED STATES,OTHER BASIC SCIENCES,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"NAGY, PETER ;",7357058;,5R21AI082143,02/13/2009,01/31/2011,"Affect; Agriculture; Animals; Antiviral Agents; Antiviral Drugs; Antivirals; Arbovirus, Group B; Area; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Breakbone Fever Virus; Cataloging; Catalogs; Cell-Free System; Cellfree System; Cells; Cellular biology; Complex; D-Glyceraldehyde-3-phosphate[{..}]NADP+ oxidoreductase; Data; Data Set; Dataset; Dengue Virus; Development; Disease; Disorder; EC 2.7.7.48; Egypt 101 virus; Enzymes; Evolution; Flavivirus; Food; GAPD; GWAS; Genes; Genome; Glyceraldehyde-3-Phosphate Dehydrogenases; Glyceraldehydephosphate Dehydrogenase; HCV; HHVA; Health; Hepatitis A Virus; Hepatitis C virus; Hepatitus C; Host Factor; Host Factor Protein; Human; Human, General; In Vitro; Integration Host Factors; Knowledge; Lead; Life; Man (Taxonomy); Man, Modern; Metabolic; Model System; Models, Biologic; Molecular Interaction; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (RNA-directed); Organism; Para-Influenza Virus Type 3; Pathogenesis; Pb element; Pestivirus; Phosphoglyceraldehyde Dehydrogenase; Plants; Plants, General; Play; Production; Programs (PT); Programs [Publication Type]; Protein Binding; Proteins; Proteomics; RNA Replicase; RNA Virus Infections; RNA Viruses; RNA replication; RNA, Viral; RNA-Dependent RNA Polymerase; RNA-Directed RNA Polymerase; Recruitment Activity; Research; Risk; Role; Social Welfare; Societies; System; System, LOINC Axis 4; Systems Biology; Tomatoes; Tombusvirus; Triosephosphate Dehydrogenase; Viral; Viral Activity; Viral Function; Viral Pathogenesis; Viral Physiology; Virus; Virus Replication; Viruses, General; WNV; West Nile; West Nile virus; Work; Yeast Model System; YeastModel; Yeasts; agricultural; base; cell biology; disease/disorder; experiment; experimental research; experimental study; gene product; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; heavy metal Pb; heavy metal lead; in vivo; insight; living system; new approaches; novel; novel approaches; novel strategies; novel strategy; parainfluenza virus type 3; pathogen; programs; public health relevance; recruit; replicase; research study; social role; tomato bushy stunt virus; transcription factor; viral RNA; virus RNA; virus host interaction; virus multiplication; welfare; whole genome association studies; whole genome association study; yeast genetics",Functional role of a host metabolic enzyme in viral replication,"  RNA viruses, which pose significant risks to human health and cause major losses for agriculture, depend heavily on host factors to replicate in infected cells. The roles of the subverted host factors in virus replication are currently poorly understood due to the lack of tractable virus-host systems. The PI will use the powerful Tomato bushy stunt virus (TBSV)-yeast model system to dissect the role of a key co-opted host factor, namely GAPDH (glyceraldehyde-3-phosphate dehydrogenase) metabolic protein that binds to the viral RNA and essential for tombusvirus replication in yeast and in the native host plant. The proposed work will lead to deeper understanding of the role of the host in RNA virus infections and likely open new antiviral strategies.",82143,ZRG1,Special Emphasis Panel,,2,201960,
7762204,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082246-02,,NIAID:243540;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PHARMACOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GIBSON, D. WADE;",2196912;,5R21AI082246,02/01/2009,01/31/2011,"AIDS; APF-1; ATP-Dependent Proteolysis Factor 1; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Affinity; Amino Acid Sequence; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Attention; Baculoviruses; Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Function; Biological Process; Birth Defects; CMV; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cells; Chemicals; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Clinical, Transplantation, Organ; Combination Chemotherapy Regimen; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Cysteine Endopeptidases; Cysteine Protease; Cysteine Proteinases; Cytomegalovirus; DNase; Deoxyribonucleases; Environment; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Esteroproteases; Funding; Genetic; Genome; Grafting Procedure; HCMV; HHV 5; HHV5; HMG-20; Herpesviridae; Herpesvirus 5 (beta), Human; Herpesviruses; High Mobility Protein 20; High Throughput Assay; Human Herpesvirus 5; Human Herpesvirus 5 species; Immune system; Immunoassay; Immunologic Deficiency Syndrome, Acquired; In Situ; Infection; Insecta; Insects; Invertebrates, Insects; Length; Libraries; Mass Spectrum; Mass Spectrum Analysis; Medical; Methods; Molecular Genetic Abnormality; Molecular Weight; NIH RFA; Nucleases, DNA; ORFs; Open Reading Frames; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Peptidases; Peptide Hydrolases; Photometry/Spectrum Analysis, Mass; Pilot Projects; Preparation; Process; Proteases; Protein Coding Region; Protein Structure, Primary; Proteinases; Proteins; Proteolytic Enzymes; Protocol; Protocols documentation; Publications; Publishing; Quimioterapia; Recombinants; Reporting; Request for Applications; Research; Research Resources; Resources; Rest; Role; Salivary Gland Viruses; Scientific Publication; Site; Source; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Testing; Thiol Protease; Transplantation Surgery; Ubiquitin; Viral; Virion; Virus; Virus Inhibitors; Virus Particle; Virus Replication; Viruses, General; Work; base; body system, allergic/immunologic; cancer chemotherapy; cytomegalovirus group; design; designing; enzyme activity; enzyme substrate; experiment; experimental research; experimental study; gene product; herpes virus; high throughput screening; human betaherpesvirus 5; human cytomegalovirus; inhibitor; inhibitor/antagonist; intervention design; member; monomer; multidisciplinary; mutant; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; parent grant; pilot study; protein sequence; prototype; public health relevance; research study; social role; success; therapy design; thioester; treatment design; viral inhibitor; virus multiplication",Cytomegalovirus Deubiquitinase pUL48:  Identifying Substrate and Inhibitors," Narrative Cytomegalovirus is a herpes-group virus that is a threat to people with weakened immune systems, including the very young and the very old. This research is directed at a recently discovered protease that removes ubiquitin from proteins, but whose function and potential as an antiviral target are unknown. We propose to identify the substrate(s) of this enzyme and identify inhibitors of its activity in high-throughput assays.",82246,ZRG1,Special Emphasis Panel,,2,243540,
7760971,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082357-02,,NIAID:189956;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BERKELEY,UNITED STATES,BIOCHEMISTRY,09,124726725,US,CA,947045940,UNIVERSITY OF CALIFORNIA BERKELEY,"MCWHIRTER, SARAH ;VANCE, RUSSELL E (contact);",6776403 (contact);9505093;,5R21AI082357,02/01/2009,01/31/2011,"Adjuvant; Bacteria; Bacterial Physiology; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Bone Marrow; Cell Communication and Signaling; Cell Signaling; Cells; Combining Site; Complement; Complement Proteins; DNA; DNA delivery; Data; Deoxyribonucleic Acid; Dinucleoside Phosphates; EC 2.7; Eukaryota; Eukaryote; Eukaryotic Cell; Expression Profiling; Expression Signature; FLJ11330; Gene Expression; Gene Products, RNA; Genes; Genetic; IFN; IRF3; IRF3 gene; Immune; Immune Response Genes; Immune response; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunologic Monitoring; Immunosurveillance; Immunotherapeutic agent; Infection; Interferon Type I; Interferons; Intracellular Communication and Signaling; Intracellular Second Messengers; Ir Gene; Kinases; Knockout Mice; Maps; Mice, Knock-out; Mice, Knockout; Microbe; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Monitoring, Immune; Monitoring, Immunologic; Monitoring, Immunological; NAK; NF-Kb-Activating Kinase Gene; Natural Immunity; Nature; Nucleic Acids; Null Mouse; Pathway interactions; Pattern; Phosphotransferases; Play; Production; Proteins; RNA; RNA, Non-Polyadenylated; Radiolabeled; Reactive Site; Receptor Signaling; Reticuloendothelial System, Bone Marrow; Ribonucleic Acid; Role; Second Messenger Systems; Second Messengers; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; T2K; TBK1; TBK1 gene; TLR protein; Testing; Therapeutic; Toll-like receptors; Transphosphorylases; Vaccine Adjuvant; Vaccines; base; biological signal transduction; bis(3',5')-cyclic diguanylic acid; body system, allergic/immunologic; c-(GpGp); c-di-GMP; cGpGp; cyclic diguanylic acid; design; designing; dinucleotide; eukaryotida; experiment; experimental research; experimental study; expression cloning; gene product; host response; immunologic preparation; immunoresponse; immunotherapeutics; improved; interest; knock-down; macrophage; molecuar profile; molecular signature; mutant; novel; organ system, allergic/immunologic; overexpression; pathogen; pathway; public health relevance; radiolabel; radiotracer; research study; response; second messenger; sensor; social role; transcription factor",A novel cytosolic immunosurveillance pathway, Project Narrative Relevance: Adjuvants are a critical component of safe and effective vaccines. Adjuvants function by stimulating cells of the innate immune system. A better understanding of how adjuvants stimulate innate immunity will allow for the design of more effective and/or safer adjuvants.,82357,III,Innate Immunity and Inflammation Study Section,,2,189956,
7762247,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082406-02,,NIAID:226463;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"STEHLIK, CHRISTIAN ;",7848853;,5R21AI082406,02/05/2009,01/31/2011,"Adaptor Protein; Adaptor Signaling Protein; Address; Adenosine Triphosphatase, Dynein; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Apoplexy; Arthritis; Asthma; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Biological; Body Tissues; Bronchial Asthma; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase-1; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell-Death Protease; Cellular Stress; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Chronic Periodontitis; Communicable Diseases; Cytosol; Data; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Developed Countries; Developed Nations; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dynein; Dynein ATPase; Dynein Adenosinetriphosphatase; EC 3.4.22.36; Edodekin Alfa; Family; Fibrosis; Goals; Grant; HDAC6; HDAC6 gene; Human; Human, General; ICE Protease; ICE-like protease; IFN-gamma-Inducing Factor; IGIF; IL-1 Gamma; IL-1 beta; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-1-b; IL-12; IL-18; IL-1b Converting Enzyme; IL-1g; IL1-Beta; IL12; IL18 Protein; IL1B Protein; IL1B-Convertase; IL1BC; IL1F2; IL1F4; INFLM; Image; Immune; Immune response; Industrialized Countries; Industrialized Nations; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Interferon-gamma-Inducing Factor; Interleukin 1, Beta Proprotein; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin 1beta; Interleukin Activation; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1 Gamma; Interleukin-1 beta; Interleukin-12; Interleukin-18; Interleukin-18 Precursor; Interleukin-1beta Converting Enzyme; Interleukins; Intracellular Communication and Signaling; JM21; KIAA0901; Knowledge; Life; Link; Lung; MGC12320; MODY; MS (Multiple Sclerosis); Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Micro-tubule; Microtubules; Modeling; Molecular; Multiple Sclerosis; NIDDM; NKSF; Natural Killer Cell Stimulatory Factor; Nerve Degeneration; Neuron Degeneration; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nucleus; P45; Pathogenesis; Pathway interactions; Patients; Pattern recognition receptor; Periodontitis; Phagocytes; Phagocytic Cell; Physiologic; Physiological; Position; Positioning Attribute; Preinterleukin 1 Beta; Primary Senile Degenerative Dementia; Process; Production; Proteins; Reaction; Receptor Protein; Recruitment Activity; Research; Research Proposals; Respiratory System, Lung; Sclerosis, Disseminated; Signal Transduction; Signal Transduction Systems; Signaling; Stress; Stroke; Structure; Symptoms; System; System, LOINC Axis 4; T2D; T2DM; Testing; Therapeutic; Time; Time Study; Tissues; Type 2 diabetes; Type II diabetes; Ulcerated Colitis; Ulcerative Colitis; Vascular Accident, Brain; Work; Wound Healing; Wound Repair; adult onset diabetes; amebocyte; arthritic; atheromatosis; atherosclerotic vascular disease; base; biological signal transduction; brain attack; caspase; cerebral vascular accident; combat; cystein protease; cystein proteinase; cysteine endopeptidase; cytokine; dementia of the Alzheimer type; design; designing; disease/disorder; dynein ATP phosphohydrolase (tubulin translocating); effective therapy; gene product; hD6; high risk; host response; imaging; immunoresponse; improved; innovate; innovation; innovative; insular sclerosis; intervention development; ketosis resistant diabetes; macrophage; maturity onset diabetes; neural degeneration; neurodegeneration; neuronal degeneration; new approaches; novel; novel approaches; novel strategies; novel strategy; pathogen; pathway; prevent; preventing; primary degenerative dementia; pro-caspase-1; procaspase-1; protein complex; public health relevance; pulmonary; receptor; recruit; response; senile dementia of the Alzheimer type; social; stroke; therapy development; tissue repair; treatment development; unspecified interleukin",Maturation of IL-1beta and IL-18 in novel macrophage aggresomes," Excessive production of IL-1¨ and IL-18 are directly responsible for the symptoms of a number of inflammatory diseases with destructive pathogenesis, including some of the most common diseases of industrialized nations, including arthritis, asthma, inflammatory bowel disease, ulcerative colitis, atherosclerosis, peridontitis, type 2 Diabetes, lung fibrosis, multiple sclerosis, Alzheimer's disease, or stroke. Currently there are no effective treatments available, causing patients life-long symptoms and a huge economical and financial impact on our social and medical systems. IL-1¨ and IL- 18 require specialized protein complexes, referred to as inflammasomes for release, but the mechanism by which inflammasomes assemble are not well understood, but are expected to provide the basis for the development of treatment options for patients suffering from inflammatory diseases. As a consequence, in this study we propose to address the mechanism of inflammasome formation, and to link inflammasomes to existing cellular ultra structures, which is expected to open new avenues for preventing uncontrolled release of IL-1¨ and IL-18.",82406,III,Innate Immunity and Inflammation Study Section,,2,226463,
7766215,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082437-02,,NIAID:205425;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BRONX,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"CHANDRAN, KARTIK ;",8776893;,5R21AI082437,02/15/2009,01/31/2011,"Achievement; Achievement Attainment; Adhesions; Africa; Animal Model; Animal Models and Related Studies; Animals; Antiviral Agents; Antiviral Drugs; Antiviral Therapy; Antivirals; Benzimidazoles; Binding; Binding (Molecular Function); Biochemical; Biological Terrorism; Biology; Bioterrorism; Breakbone Fever Virus; Cell Membrane Lipids; Cells; Chemicals; Chemistry, Pharmaceutical; Collaborations; Consult; Cysteine Endopeptidases; Cysteine Protease; Cysteine Protease Inhibitors; Cysteine Proteinase Antagonists; Cysteine Proteinase Inhibitors; Cysteine Proteinases; Cytoplasm; DF/HCC; Dana-Farber Cancer Institute; Data; Dengue Virus; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; EBOV GP; Ebola virus; Ebola virus envelope glycoprotein; Ecology; Environmental Science; Equipment; Expertise, Technical; Fluorescence Microscopy; GP Ebola virus; GP gene product, Ebola virus; Glycoproteins; Gray; Gray unit of radiation dose; HOSP; Hand; Hemorrhagic Fevers, Viral; Hospitals; Host Factor; Host Factor Protein; Human; Human Resources; Human, General; Image; Infection; Integration Host Factors; Investigators; Laboratories; Lead; Learning; Letters; Life; Man (Taxonomy); Man, Modern; Manpower; Mass Spectrum; Mass Spectrum Analysis; Mediating; Medicinal Chemistry; Membrane Fusion; Membrane Lipids; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Molecular; Molecular Interaction; Names; Nature; Nucleocapsid; Pathway interactions; Pb element; Pharmaceutic Chemistry; Pharmaceutical Chemistry; Phase; Photometry/Spectrum Analysis, Mass; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Process; Proteins; Public Health; Reagent; Reporting; Research Associate; Research Design; Research Personnel; Researchers; Role; Safety; Schools, Medical; Scientist; Shipping; Ships; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Study Type; Surface; Technical Expertise; Testing; Thiol Protease; Time; Viral; Viral Diseases; Viral Gene Products; Viral Gene Proteins; Viral Hemorrhagic Fevers; Viral Proteins; Virulent; Virus; Virus Diseases; Virus Inhibitors; Viruses, General; Woman; Work; Yang; analog; base; benzimidazole; effective therapy; envelope glycoprotein, Ebola virus; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; hemorrhagic fever; imaging; improved; inhibitor; inhibitor/antagonist; interest; medical schools; model organism; novel; pathway; personnel; post-doc; post-doctoral; public health medicine (field); public health relevance; research study; small molecule; social role; study design; tissue culture; tool; treatment of viral infectious disease; treatment strategy; uptake; viral infection; viral inhibitor; virus host interaction; virus infection; virus protein",Targets of novel Ebola virus entry inhibitors," A. Project narrative Ebola virus causes a highly lethal hemorrhagic fever and is considered to be a bioterrorism threat agent. There are currently no antiviral drugs available to treat infections by Ebola virus. We have discovered new inhibitors that block an early step of Ebola virus infection, and we intend to improve these inhibitors and find out exactly how they work.",82437,DDR,Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section,,2,205425,
7784503,R21,AI,5,,04/01/2010,03/31/2011,PA-06-519,5R21AI082880-02,,NIAID:201613;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,PATHOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"OCONNOR, DAVID H;",3135583;,5R21AI082880,04/01/2009,03/31/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Adoptive Cell Transfers; Adoptive Transfer; Alleles; Allelomorphs; Allogenic; Antigenic Determinants; Binding Determinants; CD8; CD8B; CD8B1; CD8B1 gene; Cell Count; Cell Number; Cell Transfers, Adoptive; Cells; Clinical Trials; Clinical Trials, Unspecified; Development; Epitopes; Future; HIV; HTLV-III; Haplotypes; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Immune response; Immunity; Immunodeficiency Disorder; Immunodeficiency Syndrome; Immunologic Deficiency Syndromes; Immunological Deficiency Syndromes; In Vitro; Individual; Infection; Infusion; Infusion procedures; LAV-HTLV-III; LYT3; Lymphadenopathy-Associated Virus; Lymphocyte; Lymphocytic; Macaca; Macaque; Man (Taxonomy); Man, Modern; Modeling; Nature; Population; SIV; Severities; Simian Immunodeficiency Viruses; Staging; T Cell Specificity; T-Cell Immunologic Specificity; T-Cells; T-Lymphocyte; Testing; Thymus-Dependent Lymphocytes; Time; Vaccine Design; Vaccines; Viral; Viral Diseases; Viral Genetics; Virus; Virus Diseases; Virus-HIV; Viruses, General; clinical investigation; combat; experiment; experimental research; experimental study; host response; hypoimmunity; immune deficiency disorder; immunodeficiency; immunoresponse; in vivo; lymph cell; non-human primate; nonhuman primate; prophylactic; public health relevance; research study; response; thymus derived lymphocyte; tumor; viral infection; virus genetics; virus infection",Exploring in vitro and in vivo T cell immunity to SIV with MHC-identical macaques," PROJECT NARRATIVE There is no definitive evidence that CD8+ T cells alone can reduce the severity of SIV infection, a primary objective of current vaccines. In this proposal we will identify a potent CD8+ T cell re- sponse that suppresses viral replication in vitro, expand these cells to massive numbers, and in- fuse the expanded T cells into macaques immediately before SIV challenge. For the first time we will be able to determine whether adoptively transferred CD8+ T cells alone can control SIV.",82880,AIP,AIDS Immunology and Pathogenesis Study Section,,2,201613,
7768427,R21,AI,5,,02/01/2010,01/31/2011,PA-06-181,5R21AI082916-02,,NIAID:176086;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,MADISON,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"ESCALANTE, JORGE C;",1885216;,5R21AI082916,02/12/2009,01/31/2011,"2-methylcitrate; 5'-deoxyadenosylcobalamin; Acetates; Acyl CoA; Acyl Coenzyme A; Acylation; Address; AdoCbl; Affect; Alimentary Canal; Aminoethanols; Anabolism; Animal Model; Animal Models and Related Studies; Animals; Archaea; Archaebacteria; Archaeobacteria; Archaeon; Bacteria; Biochemical; Biochemical Pathway; Biological; C element; Carbon; Catabolism; Cell Function; Cell Growth Inhibitors; Cell Process; Cell Wall; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Chemistry; Chromosomes; Citrate (si)-Synthase; Citrate Synthase; Citrate oxaloacetate-lyase ((pro-3S)-CH2COO(-)--acetyl-CoA); Citric Acid Cycle; Coenzymes; Cofactors, Enzyme; Communicable Diseases; Complex; D-Glucose; D-Ribose; Data; Dextrose; Digestive Tract; Ensure; Enzymes; Ethanolamines; Eukaryota; Eukaryote; Fatty Acid Metabolism Pathway; Fatty Acids, Short-Chain; Fatty Acids, Volatile; Fatty Acyl CoA; Food Preservatives; GI Tract; Gastrointestinal Tract; Gastrointestinal tract structure; Gene Expression; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gluconeogenesis; Glucose; Growth; Growth Inhibitors; Health; Histones; Human; Human, General; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intermediary Metabolism; Investigators; Isomerism; Knowledge; Krebs Cycle; Laboratories; Learning; Ligase; Light; Long-Chain Acyl CoA; METBL; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Networks; Metabolic Processes; Metabolism; Microbe; Molecular; Molecular Genetic; Molecular Genetics; Mutation; Nucleic Acids; Nutrition; Nutritional Science; Phenotype; Photoradiation; Physiologic; Physiological; Play; Prevention; Prokaryotae; Prokaryotic Cells; Propanediols; Propionates; Propylene Glycols; Proteins; Publishing; Research Personnel; Researchers; Ribose; Role; S. enterica; Salmonella enterica; Science of Chemistry; Science of nutrition; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirtuins; Soil; Solid; Source; Subcellular Process; Substrate Specificity; Synthetases; System; System, LOINC Axis 4; TCA cycle; Tissue Growth; Toxic effect; Toxicities; Tricarboxylic Acid Cycle; Volatile Fatty Acids; Work; adenosylcobalamin; alimentary tract; base; biosynthesis; cell growth; cobamamide; coenzyme B12; coenzyme analog; deacylation; desoxy-5'-adenosine-5' alpha-(dimethyl-5,6-benzimidazolyl)cobamide; desoxyadenosylcobalamine; dibencozide; digestive canal; enzyme activity; eukaryotida; fatty acid metabolism; gene function; gene product; genome mutation; glucose biosynthesis; gut microflora; inhibitor; inhibitor/antagonist; insight; interdisciplinary approach; interest; isomer; model organism; nutrition; ontogeny; pathogen; prevent; preventing; prokaryote; propionyl-CoA; propionyl-coenzyme A; public health relevance; social role; stereochemistry; vitamin B12 coenzyme",Molecular Basis of Propionate Toxicity, PROJECT NARRATIVE The project proposed in this application will provide insights into how propionate (a food preservative) exerts its inhibitory effects on cell growth at the molecular level. This work is relevant to human health and nutrition since propionate affects pathogenic and non-pathogenic microbes alike.,82916,ZRG1,Special Emphasis Panel,,2,176086,
7770863,R21,AI,5,,02/01/2010,01/31/2011,PA-08-053,5R21AI083076-02,,NIAID:193050;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CINCINNATI,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"CONFORTI, LAURA ;",2109403;,5R21AI083076,02/15/2009,01/31/2011,"(2,6)-sialyl T antigen; APC; ATGN; Address; Affect; Antigen-Presenting Cells; Antigens; Au element; Autoimmune; Autoimmune Diseases; Autoimmune Process; Blood Coagulation Factor IV; C element; Ca++ element; Calcium; Carbon; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell membrane; Cell physiology; Cell surface; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Coagulation Factor IV; Complex; Cytoplasmic Membrane; Data; Development; Disease; Disorder; Electrical Impedance; Electrodes; Engineering; Engineerings; Event; Factor IV; Genetic Engineering of Proteins; Gold; Image; Immune response; Immune system; Immunologic Accessory Cells; Immunosuppressants; Immunosuppressive Agents; Impedance; Intracellular Communication and Signaling; Ion Channel; Ion Channels, Potassium; Ionic Channels; K channel; KCNA3 potassium channel; Kv1.3 gene product; Kv1.3 potassium channel; Laboratories; Ligands; Location; Lupus Erythematosus Disseminatus; Lupus Erythematosus, Systemic; Lymphocyte; Lymphocyte Function; Lymphocytic; MHC Receptor; Major Histocompatibility Complex Receptor; Malignant Cell; Measurement; Membrane; Membrane Channels; Membrane Proteins; Membrane-Associated Proteins; Methods; Methods and Techniques; Methods, Other; Microscopy; Molecular; Monitor; Monocytes / Macrophages / APC; Nanoscale Science; Nanotechnology; Outcome; Patients; Pattern; Plasma Membrane; Play; Position; Positioning Attribute; Potassium Channel; Process; Protein Engineering; Proteins; Receptors, Antigen, T-Cell; Regulation; Role; SLE; SLE - Lupus Erythematosus, Systemic; ST antigen; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Structure; Subcellular Process; Surface; Surface Proteins; Synapses; Synaptic; Systemic Lupus Erythematosus; Systemic Lupus Erythmatosus; T Antigens; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; Techniques; Testing; Thymus-Dependent Lymphocytes; Viral T Antigens; Viral Tumor Antigens; Virus Transforming Antigens; Work; accessory cell; autoimmune disorder; biological signal transduction; body system, allergic/immunologic; cancer cell; college; design; designing; disease/disorder; disseminated lupus erythematosus; electric impedance; electrical property; functional outcomes; gene product; host response; imaging; immunogen; immunological synapse; immunological synapse formation; immunoresponse; immunosuppressive; interest; lymph cell; membrane structure; nano scale Science; nano tech; nano technology; nanotech; novel; organ system, allergic/immunologic; pathogen; plasmalemma; public health relevance; response; s-T antigen; sialosyl-T antigen; social role; systemic lupus erythematosis; thymus derived lymphocyte; trafficking; voltage clamp",Potassium Channel Trafficking in Geometrically Patterned Immunological Synapses," T lymphocyte function, and also therefore malfunction, is in part controlled by Kv1.3 channels in the cell membrane. We are interested in studying details of how the location of Kv1.3 channels in the contact point between T cells and antigen presenting cells affects the channels' function. To do this we propose a novel method combining nanotechnology and artificial antigen presenting cell-like surfaces.",83076,NANO,Nanotechnology Study Section,,2,193050,
7759628,R21,AT,5,,02/01/2010,01/31/2011,PA-06-315,5R21AT003677-02,,NCCAM:233145;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,CHICAGO,UNITED STATES,PHARMACOLOGY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"WANG, ZAIJIE JIM ;",1879280;,5R21AT003677,02/01/2009,01/31/2011,"3'5'-cyclic ester of AMP; 3,5 cyclic AMP synthetase; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 5-HT; 5-Hydroxytryptamine; 5HT; ATP pyrophosphate-lyase (cyclizing); Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adenyl Cyclase; Adenylate Cyclase; Adenylyl Cyclase; Adverse effects; Affect; Affective Disorders; Affinity; Agonist; American; American Psychiatric Association; Aminalon; Aminalone; Aminobutyric Acids; Angelica sinensis; Angelica sinensis preparation; Anxiety; Assay; Attenuated; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Botanicals; Bp50; Butanoic acid, 4-amino-; CD40; CDW40; Cells; Change of Life, Female; China; Clinical Research; Clinical Study; Common Rat Strains; Cyclic AMP; Data; Depression; Diet Supplement; Dietary Supplements; Dose; Drug usage; Effectiveness; Endogenous Opiates; Ensure; Enteramine; Exhibits; Female; Female Health; Future; G-Proteins; GABA; GABA-A Receptor; GTP-Binding Proteins; GTP-Regulatory Proteins; Gonadal Steroid Hormones; Grant; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Health; Herb; High Throughput Assay; Hippophaine; Hormonal; Hot flushes; Hyperalgesia; Hyperalgesic Sensations; IC50; Inhibitory Concentration 50; Insomnia; Insomnia Disorder; Ligands; MGC9013; Mainland China; Mammals, Rats; Mammals, Rodents; Measures; Medical; Menopausal Symptom; Menopause; Mental Depression; Methods; Modeling; Molecular; Molecular Interaction; Molecular Mechanisms of Action; Mood Disorders; Moods; Nerve Transmitter Substances; Neurotransmitters; Nutritional Supplement; Opiates; Opioid Receptor; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physiologic; Physiological; Plant Roots; Population; Premenstrual syndrome; Programs (PT); Programs [Publication Type]; Rat; Rattus; Receptor Activation; Receptor Protein; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; Receptors, Opiate; Regulation; Research; Rodent; Rodentia; Rodentias; Series; Serotonin; Sex Hormones; Sex Steroid Hormones; Site; Sleeplessness; Symptoms; Synaptosomes; System; System, LOINC Axis 4; TNFRSF5; TNFRSF5 gene; Testing; Time; Treatment Side Effects; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; United States; Woman; Women's Health; adenosine 3'5' monophosphate; adenylcyclase; base; cAMP; dong quai; drug use; endogenous opioid; experiment; experimental research; experimental study; gamma-Aminobutyric Acid; gonadal steroids; high throughput screening; hot flash; hyperalgia; in vivo; innovate; innovation; innovative; menopausal; p50; premenstrual dysphoric disorder; programs; protein activation; public health relevance; receptor; receptor binding; research study; root; sex steroid; side effect; synaptoneurosome; therapy adverse effect; treatment adverse effect",Molecular mechanisms of Angelica sinensis (Oliv.) Diels in women?s health," A large segment of the female population is affected by premenstrual syndrome (PMS) and menopausal symptoms. Although Angelica sinensis (Oliv.) Diels is one of the most commonly used botanical dietary supplements for the relief of PMS and menopausal symptoms, little is known for its mechanisms. This application aims to apply molecular methods to study mechanisms of action of Angelica sinensis.",3677,ZAT1,Special Emphasis Panel,,2,233145,
7762842,R21,AT,5,,02/01/2010,01/31/2011,PA-06-315,5R21AT003878-02,,NCCAM:195525;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"SCHWABE, ROBERT F.;",8451386;,5R21AT003878,02/01/2009,01/31/2011,"Adverse effects; Antibiotic Agents; Antibiotic Drugs; Antibiotic Therapy; Antibiotic Treatment; Antibiotics; Antibiotics, Combined; Bacteria; Bacterial Translocation; Bile Ducts; Bile duct structure; Blood Serum; Blood leukocyte; Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Chronic; Cirrhosis; Clinical; Closure by Ligation; Combinations, Antibiotic; Combined Antibiotics; Data; Deposit; Deposition; Development; Disease Progression; Drug Combinations, Antibiotic; ECM; Enteral; Enteric; Environment; Experimental Models; Experimental Models, Other; Exposure to; Extracellular Matrix; Fibrosis; Future; Gastrointestinal Tract, Small Intestine; Gram-Negative Bacteria; Hepatic; Hepatic Disorder; Hepatic Fibrogenesis; Hepatic Stellate Cell; INFLM; Infection; Inflammation; Inflammatory; Injection of therapeutic agent; Injections; Injury; Intestinal; Intestinal Motility; Intestines; Intestines, Small; Intracellular Communication and Signaling; Ito Cell; LPS; Lead; Leukocytes; Ligation; Lipopolysaccharides; Liver; Liver Fibrosis; Liver diseases; Mammals, Mice; Marrow leukocyte; Membrane; Mice; Miscellaneous Antibiotic; Modality; Modeling; Models, Experimental; Motility, Intestinal; Motor; Murine; Mus; Pathway interactions; Patients; Pb element; Play; Prevention; Preventive; Probiotics; Production; Receptor Protein; Regimen; Reticuloendothelial System, Leukocytes; Role; Safety; Sequential Treatment; Serum; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Intestines; Staging; Structure; TLR4 receptor; Testing; Toll-4 receptor; Treatment Side Effects; White Blood Cells; White Cell; base; bile duct; bile ductule; biological signal transduction; body system, hepatic; bowel; cell type; fibrogenesis; heavy metal Pb; heavy metal lead; hepatic fibrosis; hepatopathy; injured; liver disorder; liver fibrogenesis; membrane structure; mouse model; novel; organ system, hepatic; pathway; prevent; preventing; public health relevance; receptor; side effect; small bowel; social role; therapy adverse effect; toll-like receptor 4; treatment adverse effect; treatment of bacterial diseases; treatment of bacterial infectious disease; white blood cell; white blood corpuscle",Prevention of Hepatic Fibrosis by Probiotics," Project Narrative This proposal investigates probiotics as a potential treatment option for liver fibrosis. Probiotics have been shown to be a feasible and safe treatment option in patients. Thus, results from experimental murine fibrosis in this study may have clinical implications and lead to future studies that investigate the efficacy of probiotics in patients with chronic liver disease and liver fibrosis.",3878,ZAT1,Special Emphasis Panel,,2,195525,
7788072,R21,AT,5,,01/01/2010,12/31/2010,PA-06-510,5R21AT003939-03,,NCCAM:183150;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"KESHAVARZIAN, ALI ;",1970659;,5R21AT003939,01/01/2008,12/31/2010,"27E10 Antigen; ACTH; ACTH (1-39); Address; Adherence; Adherence (attribute); Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Attention; Attenuated; Attitude; Basophilic Histiocyte; Basophils, Tissue; Belief; Blood; Body Tissues; Brain; Calcium-Binding Myeloid Protein P8,14; Calgranulin; Calprotectin; Cetacort; Clinical; Clinical Trial Overviews; Clinical Trials; Clinical Trials, Unspecified; Complex; Control Groups; Cort-Dome; Cortef; Cortenema; Corticotropin; Corticotropin (1-39); Cortisol; Cortispray; Cortril; Data; Data Pooling; Data Poolings; Dermacort; Development; Disease; Disease remission; Disorder; Dropout; Drops; Drugs; Education; Educational aspects; Educational process of instructing; Eldecort; Encephalon; Encephalons; Enrollment; Equipment and supply inventories; Event; Feces; Flare; Frequencies (time pattern); Frequency; Future; Gastrointestinal Tract, Feces; Goals; Gut Inflammation; Hand; Health; Hydrocortisone; Hydrocortone; Hytone; INFLM; Immune Function, Cellular; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Diseases of the Intestinal Tract; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory Response; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Injury; Intervention; Intervention Strategies; Intestinal; Intestinal Inflammation; Intestines; Inventory; Kentucky; L1 Antigen; Lectures; Lectures (PT); Lectures [Publication Type]; Leukocyte L1 Antigen Complex; Leukocyte L1 Protein; Life; Marrow Mast Cell; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Meditation; Meta-Analyses; Meta-Analysis; Methods; Methods and Techniques; Methods, Other; Migratory Inhibitory Factor-Related Protein MRP; Mind-Body Intervention; Mind-Body Medicine; Mind-Body Medicine (with OBSSR); Minor; Modeling; Mucosal Inflammation; Mucositis; Multicenter Studies; Myelomonocytic Antigen L1; Nervous System, Brain; Nutracort; Outcome Measure; Outcome Study; Participant; Patients; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physiologic; Physiological; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Preparation; Principal Investigator; Probiotics; Proctocort; Programs (PT); Programs [Publication Type]; Proteins; Psychological Stress; Publications; Questionnaires; RMSN; Randomized; Recruitment Activity; Recurrence; Recurrent; Refusal to Participate; Relapse; Remission; Research Design; Resistance; Reticuloendothelial System, Blood; Review Literature; Risk; Risk Reduction; Role; Sample Size; Sampling; Scanning; Scientific Publication; Severities; Stress; Stress, Psychological; Stressful Event; Structure; Study Type; Study, Outcome; Symptoms; TXT; Teaching; Techniques; Testing; Text; Therapeutic Hydrocortisone; Time; Tissues; Toxic effect; Toxicities; Training; Ulcerated Colitis; Ulcerative Colitis; Yoga; attenuation; base; biological adaptation to stress; bowel; clinical investigation; clinical relevance; clinically relevant; conventional therapy; design; designing; disease risk; disease/disorder; disorder risk; double-blind placebo controlled trial; double-masked controlled study; double-masked controlled trial; drug/agent; enroll; experience; gene product; hazard; human subject; immune function; indexing; inflammatory marker; innovate; innovation; innovative; instructor; interventional strategy; lectures; mast cell; mastocyte; mind body approach; mind body medicine skills; mind body method; mind body techniques; mind body therapy; mind body treatments; mind body wellness; mindfulness; mindfulness-based stress reduction; oxidation; prevent; preventing; primary outcome; programs; psychologic; psychological; randomisation; randomization; randomly assigned; reaction; crisis; recruit; resistant; response; secondary outcome; skills; social role; stool; stress response; stress; reaction; stressor; study design; urinary","Mindfulness, Stress, and IBD Flare-Up",,3939,ZAT1,Special Emphasis Panel,,3,183150,
7762734,R21,AT,5,,02/01/2010,01/31/2011,PA-06-315,5R21AT004576-02,,NCCAM:190227;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,NEW YORK,UNITED STATES,PSYCHIATRY,14,121911077,US,NY,10016,NEW YORK UNIVERSITY SCHOOL OF MEDICINE,"GABBAY, VILMA ;",7861828;,5R21AT004576,02/01/2009,01/31/2011,"12-20 years old; 1H- Nuclear Magnetic Resonance Spectroscopic Imaging; 2-Hydroxy-N,N,N-trimethylethanaminium; 21+ years old; 3-aminobutyric acid; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Adverse Experience; Adverse event; Affect; Age; American Psychiatric Association; Aminalon; Aminalone; Aminobutyric Acids; Anterior; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Arm; Atrophic; Atrophy; Basal Ganglia; Basal Nuclei; Bipolar Depression; Blood erythrocyte; Blood normocyte; Brain; Brain Chemistry; Brain region; Butanoic acid, 4-amino-; Cause of Death; Cell Communication and Signaling; Cell Signaling; Cessation of life; Chemicals; Childhood; Choline; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Communities; Complementary and alternative medicine; Corpus Striatum; Corpus striatum structure; Creatine; Cytosol; Data; Death; Depression; Diagnosis; Disease; Disorder; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drugs; Dysfunction; Eating; Encephalon; Encephalons; Enrollment; Erythrocytes; Erythrocytic; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; Exhibits; Face; Fatty Acids; Fatty Acids, Omega-3; Feeling suicidal; Food Intake; Functional disorder; GABA; Glia; Glial Cells; Gliosis; Gln; Glutamates; Glutamine; Glycine, N-(aminoiminomethyl)-N-methyl-; Goals; Human, Adult; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Knowledge; Kolliker's reticulum; L-Glutamate; L-Glutamine; Lead; Left; Literature; METBL; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Major Depressive Disorder; Marrow erythrocyte; Medical; Medication; Membrane; Mental Depression; Metabolic; Metabolic Processes; Metabolism; Methods; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myelin; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neuroglia; Neuroglial Cells; Neurons; Neurotransmitters; Non-neuronal cell; Occipital lobe; Omega-3 Fatty Acids; Omega-3 PUFA; Omega-3 Polyunsaturated Fatty Acid; Onset of illness; PBO; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphates; Phosphatides; Phospholipids; Physiopathology; Pilot Projects; Placebos; Play; Property; Property, LOINC Axis 2; Protocol; Protocols documentation; Proton Magnetic Resonance Spectroscopic Imaging; Public Health; Putamen; Q. Levoglutamide; Randomized; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Relative; Relative (related person); Research; Resolution; Rest; Reticuloendothelial System, Erythrocytes; Role; Sampling; Scanning; Science of neurochemistry; Severities; Sham Treatment; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Striate Body; Striatum; Structure; Structure of putamen; Suicidal thoughts; Testing; Therapeutic; Time; Translations; Upper arm; Work; adolescence (12-20); adult human (21+); base; beta-aminobutyric acid; biological signal transduction; blind; blood corpuscles; children's depression rating scale; cingulate cortex; clinical investigation; control trial; cost; density; disease onset; disease/disorder; disorder onset; double-blind placebo controlled trial; double-masked controlled study; double-masked controlled trial; drug/agent; effective therapy; enroll; expectation; facial; frontal cortex; frontal lobe; gamma-Aminobutyric Acid; heavy metal Pb; heavy metal lead; impression; improved; in vivo; inorganic phosphate; juvenile; juvenile human; magnetic field; magnetic resonance spectroscopic imaging; major depression; membrane structure; n-3 Fatty Acids; nerve cement; neurobiological mechanism; neurochemistry; neuroimaging; neuronal; novel; occipital cortex; omega-3; pathophysiology; pediatric; pilot study; placebo controlled study; placebo controlled trial; public health medicine (field); putamen; randomisation; randomization; randomly assigned; response; sham therapy; social role; striatal; suicidal ideation; suicidal risk; suicidal thinking; suicide ideation; suicide risk; teenage; thoughts about suicide; translational approach; treatment effect; week trial",The Role of Omega-3 Fatty Acids in Adolescent Depression," Project Narrative This work seeks to lay the groundwork for translational approaches aimed at enhancing our understanding of the mechanisms of action of complementary and alternative medicines (CAM's) such as omega-3 fatty acids (FA). This study examines the effects of omega-3FA on brain chemicals in adolescents with major depressive disorder (MDD), a major public health concern. Laying the scientific groundwork for potentially important CAM's such as omega-3FA will accelerate their appropriate incorporation into standard medical practice (bedside to community translation) in specific disorders such as MDD.",4576,ZAT1,Special Emphasis Panel,,2,190227,
7752813,R21,AT,5,,01/01/2010,12/31/2010,PA-06-315,5R21AT004620-02,,NCCAM:188228;,2010,NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE,,TORRANCE,UNITED STATES,,36,069926962,US,CA,90502,LA BIOMED RES INST/ HARBOR UCLA MED CTR,"MA, SHENG-XING ;",8062110;,5R21AT004620,01/01/2009,12/31/2010,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; Absence of pain sensation; Absence of sensibility to pain; Acupoints; Acupuncture Points; Acupuncture Therapy; Acupuncture procedure; Address; Affect; Allergy; Aminalon; Aminalone; Aminobutyric Acids; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Anesthesia and Analgesia; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Arginine; Arginine, L-Isomer; Assay; Autonomic pain; Bioassay; Biochemical; Biologic Assays; Biological Assay; Brain; Brain Stem; Brain Ventricle; Brainstem; Butanoic acid, 4-amino-; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Central gray substance of midbrain; Cerebral Ventricles; Chemicals; Chinese Traditional Medicine; Chronic; Chung I Hsueh; Clinical; Common Rat Strains; Cutaneous; Cyclic GMP; Depressed mood; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Diabetic Neuropathies; Disease; Disorder; Distress; Dorsal; Drugs; Dysfunction; EC 1.14.13.39; EDRF Synthase; Electroacupuncture; Encephalon; Encephalons; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Feels no pain; Foot; Frequencies (time pattern); Frequency; Functional disorder; Future; GABA; Generations; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guanylyl Cyclase-Activating Factor Synthase; Heating; Hindlimb; Human; Human, General; Hyperalgesia; Hyperalgesic Sensations; Hypersensitivity; IDD; IDDM; Impairment; Infusion; Infusion procedures; Insulin-Dependent Diabetes Mellitus; Intracellular Communication and Signaling; Investigators; L-Arginine; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lead; Lesion; Mammals, Rats; Man (Taxonomy); Man, Modern; Mechanics; Mediating; Medical center; Medication; Medicine, Chinese Traditional; Mesencephalic Central Gray; Methods and Techniques; Methods, Other; Midbrain Central Gray; Modeling; Molecular; Mononitrogen Monoxide; NADPH-Diaphorase; NCCAM; NO Synthase; NOS 1 protein; National Center for Complementary and Alternative Medicine; Needles; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neural Pathways; Neural Transmission; Neurochemistry; Neurocyte; Neurons; Neuropathy; Neurotransmitters; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrites; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; No sensitivity to pain; Nociception; Nucleus; Nucleus Tractus Solitarii; Nucleus solitarius; Opioid; Opioid Receptor; Pain; Pain Threshold; Pain Tolerance Level; Painful; Pathway interactions; Patients; Pb element; Periaqueductal Gray; Peripheral; Peripheral Sensory Neuropathy; Pes; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiopathology; Play; Postdoc; Postdoctoral Fellow; Predisposition; Pressure; Pressure- physical agent; Principal Investigator; Process; Public Health; Rat; Rat model of diabetes; Rattus; Receptors, Opiate; Recovery; Reflex; Reflex action; Regulation; Reporting; Research Associate; Research Personnel; Researchers; Role; STZ; Science; Science of neurochemistry; Sensory; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Site; Solitary Nucleus; Stimulus; Streptozocin; Streptozotocin; Structure; Susceptibility; Synaptic Transmission; Syndrome; System; System, LOINC Axis 4; T1 diabetes; T1D; T1DM; Techniques; Temperature; Testing; Thalamic structure; Thalamus; Therapeutic Effect; Type 1 diabetes; Vibration; Vibration - physical agent; Visceral; Visceral pain; Withdrawal; Zanosar; Zhong Yi Xue; acupuncture; afferent nerve; analgesia; annulus of the aqueduct; base; biological signal transduction; cGMP; depressed; diabetes-associated neuropathy; diabetic; diabetic patient; diabetic rat; diabetic rat model; disease/disorder; dorsal column; drug/agent; endothelial cell derived relaxing factor; experience; experiment; experimental research; experimental study; foot; gamma-Aminobutyric Acid; guanosine 3'5' monophosphate; heavy metal Pb; heavy metal lead; hyperalgia; immunoreactivity; improved; inhibitor; inhibitor/antagonist; insight; insulin dependent diabetes; juvenile diabetes; juvenile diabetes mellitus; ketosis prone diabetes; midbrain central gray substance; nNOS enzyme; neurochemistry; neuronal; neuronal nitric oxide synthase; neuropathic; new approaches; nociceptive; novel; novel approaches; novel strategies; novel strategy; pain tolerance; pathophysiology; pathway; periaqueductal gray matter; post-doc; post-doctoral; posterior column; pressure; public health medicine (field); public health relevance; research study; response; sadness; sensory nerve; sensory neuropathy; social role; solitary tract nucleus; somatosensory; thalamic; type I and type II diabetes; type I diabetes; vibration; vibration perception",Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy," Title: Effects of acupuncture-induced nNOS-NO in dorsal medulla on sensory neuropathy Project Narrative These studies should advance our understanding of the biochemical mechanisms of acupuncture-induced nitric oxide on sensory/pain regulation in the dorsal medulla, and reveal a therapeutic effect of acupuncture on improving hyperalgesia and hypersensitivity by affecting nitric oxide release/synthesis in the brain sites. The results should benefit public health by exploring a novel anti-nociceptive mechanism of acupuncture and by establishing a better acupuncture therapy based on scientific evidence of inducing nitric oxide and its synthase in the dorsal medulla for treatmentof of sensory diabetic neuropathies and other pain syndroms.",4620,ZAT1,Special Emphasis Panel,,2,188228,
7774303,R21,CA,5,,03/01/2010,02/28/2011,PA-06-351,5R21CA128779-02,,NCI:180481;,2010,NATIONAL CANCER INSTITUTE,,PHILADELPHIA,UNITED STATES,,02,073724262,US,PA,191112434,FOX CHASE CANCER CENTER,"MANNE, SHARON L;",1864024;,5R21CA128779,03/01/2009,02/28/2011,"Address; Adopted; American Cancer Society; Attitude; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Booklets; Brochures; Cancer Cause; Cancer Etiology; Cancers; Caring; Cessation of life; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Colorectal Cancer; Conditioning Therapy; Couples; Data; Death; Death Rate; Diet; Disease; Disorder; Drugs, Nonproprietary; Exploratory/Developmental Grant; Feasibility Studies; Fecal Occult Blood Test; Fecal occult blood; Feedback; Future; Generic Drugs; Goals; Guaiac Smear Test; Health; Health behavior; Health behavior change; Health system; Healthy People 2010; Hemoccult; Individual; Intervention; Intervention Strategies; Interview; Investigators; Lead; Life Style Modification; Malignant Neoplasms; Malignant Tumor; Marital Relationships; Married Persons; Mate Selections; Modeling; Monitor; Mortality; Mortality Vital Statistics; Motivation; Pamphlets; Participant; Partner in relationship; Pb element; Perception; Physical activity; Pilot Projects; Prevention; Printing; Proctosigmoidoscopy; Psychologic Theory; Psychological Theory; R21 Mechanism; R21 Program; Relationships, Marital; Reporting; Research; Research Personnel; Researchers; Review Literature; Risk; Role; SCHED; Sampling; Schedule; Screening for Colorectal Cancer; Screening procedure; Selections, Mate; Sigmoidoscopy; Smoking; Social Environment; Spouses; Stool guaiac test; Testing; Time; Treatment Efficacy; United States; base; behavior change; behavior intervention; behavioral intervention; cancer risk; colorectal cancer screening; disease/disorder; drinking; early detection of colorectal cancer; efficacy testing; generic; health belief; health-related belief; heavy metal Pb; heavy metal lead; heme occult blood test; improved; information gathering; innovate; innovation; innovative; intervention development; intervention effect; interventional strategy; malignancy; mate; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; pilot study; public health relevance; randomized trial; risk perception; screening; screenings; social; social climate; social context; social role; socioenvironment; successful intervention; theories; therapeutic efficacy; therapeutically effective; therapy development; treatment development; uptake",Couple-Based Intervention for Colorectal Cancer Screening," Public Health Relevance While uptake rates for colorectal cancer screening have been increasing, participation in screening remains relatively low, particularly in comparison with other cancers and when considering prevention objectives set forth in Healthy People 2010. Novel approaches for improving CRCS need to be developed. In the proposed study, we seek to develop and pilot test an innovative, theoretically-guided, couple-based intervention whose goal is to encourage couples to constructively discuss having CRCS, with the ultimate goal of increasing the uptake of CRCS among couples in which neither partner is on-schedule with regard to CRCS.",128779,PRDP,Psychosocial Risk and Disease Prevention Study Section,,2,180481,
7759598,R21,CA,5,,02/01/2010,01/31/2011,PA-06-351,5R21CA129890-02,,NCI:228690;,2010,NATIONAL CANCER INSTITUTE,,MADISON,UNITED STATES,ENGINEERING (ALL TYPES),02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"WISE, MARGARET E;",8246362;,5R21CA129890,02/01/2009,01/31/2011,"0-11 years old; 21+ years old; Address; Adult; Advanced Cancer; Advanced Malignant Neoplasm; Age; Aged 65 and Over; Cancer Patient; Cancers; Care Givers; Caregivers; Cessation of life; Child; Child Youth; Children (0-21); Communication; Communities; Compassion; Comprehensive Cancer Center; Computers; Control Groups; Death; Distress; Early treatment; Education; Educational Materials; Educational aspects; Elderly; Elderly, over 65; Exploratory/Developmental Grant; Family; Family member; Focus Groups; Friends; Fruit; Generalized Growth; Goals; Growth; Health; Heterogeneity, Population; Home; Home environment; Hospices; Human, Adult; Human, Child; Individual; Internet; Intervention; Intervention Strategies; Interview; Knowledge; Learning; Life; Link; Malignant Neoplasms; Malignant Tumor; Manuscripts; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Minority; Mortality; Mortality Vital Statistics; Nature; Needs Assessment; On-Line Systems; Online Systems; Outcome; Pain; Painful; Participant; Patients; Personal Satisfaction; Phone; Physicians; Population; Population Heterogeneity; Process; Protocol; Protocols documentation; Publishing; R21 Mechanism; R21 Program; Randomized; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Resources; Resources; Services; Social Interaction; Social Network; Social Support System; Social support; Source; Spiritualities; Spirituality; Staging; Structure; Support System; Survey Instrument; Surveys; Telephone; Telephone Interviews; Testing; Time; Tissue Growth; Training; Universities; WWW; Wisconsin; Work; Writing; adult human (21+); advanced age; base; children; coping; cost; cost effective; design; designing; dietary fruit; diverse populations; elders; experience; experiment; experimental research; experimental study; geriatric; grandchild; heterogeneous population; hospice environment; improved; intervention design; interventional strategy; late life; later life; loved ones; malignancy; mid life; mid-life; middle age; middle aged; midlife; neoplasm/cancer; older adult; older person; online computer; ontogeny; peer; prototype; psychological distress; public health relevance; randomisation; randomization; randomized controlled study; randomly assigned; recruit; research study; senior citizen; skills; social; social support network; therapy design; tool; treatment design; web; web based; web site; web-based social networking; well-being; world wide web; youngster",Online Narrative Interventions and Family Support for Advanced Cancer Patients," Summary The purpose of this study is evaluate the effects of a narrative intervention that provides middle- aged advanced cancer patients with a telephone interview to elicit a dignity-enhancing life story, a well-honed life story manuscript, and a project-specific personalized website with life review educational resources embedded within a social networking platform. We hypothesize that the My Living Story (MLS} intervention will enhance existential well-being and reduce psychological distress. Exploratory analyses of possible mediators, learning processes and feasibility of implementing this intervention will also be conducted for this R21 research study. We will recruit 100 advanced cancer patients who will be randomized to MLS intervention or to a control group, called My Own Resources (MOR). MOR participants receive a needs assessment telephone interview, a summary of their results with recommended resources, and a personalized website with links to salient information and a peer discussion blog. Both interventions are 2 months. We will survey at 0, 2 and 4 months.",129890,BMIO,"Behavioral Medicine, Interventions and Outcomes Study Section",,2,228690,
7761273,R21,CA,5,,02/01/2010,01/31/2011,PA-06-351,5R21CA131795-02,,NCI:159463;,2010,NATIONAL CANCER INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","BARTON, DEBRA L (contact);ELKINS, GARY R;",7360711;7593078 (contact);,5R21CA131795,02/01/2009,01/31/2011,"1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; Adverse effects; After Care; After-Treatment; Aftercare; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Anxiety; Appetite; Area; Arm; Asialia; Asialias; Bathing; Baths; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Benefits and Risks; Change of Life, Female; Chemotherapy-Hormones/Steroids; Clinical Trials; Clinical Trials, Unspecified; Clothing; Clothings; Conditioning Therapy; Confidence Intervals; Constipation; Corpus Luteum Hormone; Data; Delta4-pregnene-3,20-dione; Desire for food; Diaries; Diaries (PT); Diaries [Publication Type]; Dose; Drug usage; Drugs; Emotions; Endocrine Gland Secretion; Enteramine; Estrogen Therapy; Estrogenic Agents; Estrogenic Compounds; Estrogens; Evaluation; Expectancy; Female Health; Fluoxetin; Fluoxetine; Goals; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare worker; Heart; Hippophaine; Hormone Replacement Rx; Hormone replacement therapy; Hormones; Hot flushes; Hypnosis; Hyposalivation; Hyposalivations; Interruption; Intervention; Intervention Strategies; Intervention Studies; Jobs; Knowledge; Levarterenol; Levonorepinephrine; Life; Life Style Modification; Living Wills; Measures; Medication; Menopausal Symptom; Menopause; Moods; Mouth Dryness; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Nausea; Noradrenaline; Norepinephrine; Occupations; PBO; Palpitations; Panic; Paroxetine; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Pill; Pilot Projects; Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-; Placebos; Porifera; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Pregn-4-ene-3,20-dione; Pregnenedione; Professional Postions; Progesterone; Programs (PT); Programs [Publication Type]; Publications; QOL; Quality of life; Questionnaires; Randomized; Randomized Clinical Trials; Reporting; Research; Role; Scientific Publication; Serotonin; Sham Treatment; Sleep; Sponges; Sponges (Zoology); Sweat; Sweating; Symptoms; Testing; Therapeutic Estrogen; Therapeutic Hormone; Therapeutic Progesterone; Time; Treatment Side Effects; Trials, Randomized Clinical; Upper arm; Woman; Women's Health; Work; Xerostomia; Xerostomias; aptyalism; base; behavior intervention; behavioral intervention; biobehavior; biobehavioral; clinical investigation; diaries; drug use; drug/agent; dry mouth; effective therapy; expectation; experience; health care personnel; health care worker; health provider; health related quality of life; healthcare personnel; hot flash; improved; innovate; innovation; innovative; interventional strategy; medical personnel; meetings; menopausal; novel; patient expectation; perspiration; pill (pharmacologic); pilot study; pilot trial; post-menopausal; postmenopausal; programs; prospective; public health relevance; randomisation; randomization; randomly assigned; secondary outcome; sham therapy; side effect; social role; standard care; symptom management; theories; therapy adverse effect; treatment adverse effect; treatment provider; venlafaxine",Evaluation of a biobehavioral intervention for hot flashes," This project will be the first step to a larger study evaluating the combination of low dose venlafaxine (37.5 mg and 75 mg) with self-hypnosis for reducing hot flashes. This is a novel combination with the potential to reduce hot flashes equal to estrogen based therapy without significant unwanted side effects. The risk/benefit of estrogen therapy has recently been deemed negative with respect to hot flash management, yet hot flashes can significantly negatively impact one's life. Therefore, effective treatments without unwanted side effects are needed. The novelty of combining a pharmacologic with a non-pharmacologic intervention in a large clinical trial for hot flashes is unprecedented. This pilot study will provide the data to go forward with a large, definitive trial. In addition, information regarding moderating variables of expectancy and hypnotizability will be gained.",131795,PRDP,Psychosocial Risk and Disease Prevention Study Section,,2,159463,
7758352,R21,CA,5,,01/29/2010,12/31/2010,PA-06-510,5R21CA132236-02,,NCI:208677;,2010,NATIONAL CANCER INSTITUTE,,PORTLAND,UNITED STATES,NEUROSCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"SHANNON, JACKILEN ;",1876817;,5R21CA132236,01/15/2009,12/31/2011,"Address; Adjuvant Chemotherapy; Adjuvant Therapy; Adverse effects; Alternative Therapies; American; Animal Model; Animal Models and Related Studies; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Attention; Blood; Blood Cells; Blood Plasma; Body Tissues; Breast Cancer Cell; Breast Cancer Model; Breast Tissue; Cancer Patient; Cancer Radiotherapy; Cancer Staging; Cancer of Breast; Cancerous; Cancers; Carcinoma, Intraductal; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell-Death Protease; Cellular Proliferation; Chemopreventive; Chemopreventive Agent; Chemoprotectants; Chemoprotection; Chemoprotective; Chemoprotective Agent; Chemoprotective Drugs; Chemotherapy, Adjuvant; Clinical; Clinical Research; Clinical Study; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Consumption; Cruciform Vegetables; DCIS; Data; Development; Diagnosis; Diagnostic Neoplasm Staging; Diet; Dietary Assessment; Disease; Disease Progression; Disorder; Dose; Drug Therapy, Adjuvant; Ductal; Ductal Breast Carcinoma In Situ; Ductal Carcinoma In Situ; Ductal Hyperplasia; Effectiveness; Emerogenes; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Evaluation; Event; Food; Forecast of outcome; Foundations; Future; Gene Inactivation; Gene Silencing; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genital System, Male, Prostate; Grouping; Growth; Health Care Costs; Health Costs; Healthcare Costs; Histone Acetylation; Histone H4; Histones; Human; Human Breast Cancer Cell; Human Prostate; Human Prostate Gland; Human Volunteers; Human, General; ICE-like protease; In Vitro; Intake; Intervention Studies; Intraductal Carcinoma of the Breast; Intraductal Hyperplasia; Liquid substance; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammary Gland Parenchyma; Mammary Gland Tissue; Mammary Glands, Human; Mammary gland; Man (Taxonomy); Man, Modern; Measurable; Medical; Methods; Methods and Techniques; Methods, Other; Nature; Neoplasm Staging; Nipples; Non-Infiltrating Ductal Breast Adenocarcinoma; Non-Infiltrating Ductal Carcinoma of the Breast; Non-Infiltrating Intraductal Adenocarcinoma; Non-Infiltrating Intraductal Breast Adenocarcinoma; Non-Infiltrating Intraductal Carcinoma; Non-Invasive Ductal Breast Adenocarcinoma; Non-Invasive Ductal Carcinoma of the Breast; Non-Invasive Intraductal Breast Adenocarcinoma; Noninfiltrating Intraductal Carcinoma; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Pathway interactions; Patients; Penetration; Peripheral Blood Cell; Phytochemical; Plasma; Population Study; Prevention; Prognosis; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate Gland; Prostatic Gland; QOL; Qualifying; Quality of life; Radiation therapy; Radiotherapeutics; Radiotherapy; Recommendation; Reporting; Research; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Risk; Role; Serum, Plasma; Staging; Structure; Sulfaforaphane; Sulforaphane; Supplementation; Surgical; Surgical Interventions; Surgical Procedure; Techniques; Testing; Tissue Growth; Tissues; Toxic effect; Toxicities; Treatment Side Effects; Tumor Staging; Tumor Suppressing Genes; Tumor Suppressor Genes; Urinary System, Urine; Urine; Volunteers, Human; Woman; anticarcinogenic; base; biomarker; breast cancer diagnosis; cancer cell; cancer prevention; caspase; combat; cruciferous vegetable; cystein protease; cystein proteinase; cysteine endopeptidase; disease/disorder; effective therapy; fluid; groupings; healthy volunteer; improved; in vivo; inhibitor; inhibitor/antagonist; interest; irradiation; liquid; malignancy; malignant breast neoplasm; mammary; mammary cancer model; mammary tumor model; methylsulfoxybutylisothiocyanate; model organism; neoplasm/cancer; novel; oncosuppressor gene; ontogeny; outcome forecast; pathway; peripheral blood; prevent; preventing; public health relevance; randomized placebo controlled study; randomized placebo controlled trial; resistance to therapy; resistant to therapy; side effect; social role; success; sulforafan; sulforophane; surgery; therapy adverse effect; therapy resistant; treatment adverse effect; tumor growth; tumorigenesis; tumorigenic; urinary",Sulforaphane: A Dietary HDAC Inhibitor and Prevention of DCIS Progression," Sulforaphane, A Dietary HDAC Inhibitor, and Prevention of DCIS Progression PROJECT NARRATIVE Significant advances in the diagnosis and medical management of ductal carcinoma in situ (DCIS) have markedly reduced disease progression and improved long-term survival. However, despite overall good outcomes, the effective treatment of DCIS still requires surgery and radiation therapy, and we need better methods of preventing disease progression. There are limited medically accepted options for neo-adjuvant therapy to improve surgical success, and the typical neo-adjuvant chemotherapy given for invasive disease does not impact DCIS outcome due, in part, to decreased penetration into the ductal space. Thus, it is common for women to seek alternative therapies in an attempt to improve outcome. Hence, there is a need for scientifically directed evaluation of dietary substances that may effectively inhibit the progression of DCIS. A number of epidemiologic studies have reported an inverse association between cruciferous vegetable intake and risk of breast cancer, though not all findings are consistent. Unfortunately, many of the population studies are limited by the imprecision of dietary assessment techniques, and the grouping of all diagnoses of breast cancer, regardless of stage, as a single outcome. It has been suggested that dietary compounds function as chemoprotection agents, by both blocking initiation and suppressing cell proliferation post- initiation and thus slowing disease progression. Sulforaphane (SFN), a phytochemical found in cruciferous vegetables has been demonstrated to inhibit breast cancer cell proliferation and enhance apoptosis, both in vitro and in vivo. More recently, the role of gene silencing via EPIGENETIC alterations such as acetylation of histone structure has emerged an important factor in tumorigenesis and resistance to therapy in several cancers. Pharmacological inhibitors of histone deaceylases (HDAC) have induce apoptosis and decrease cancer cell proliferation in breast cancer cells both in vitro and in vivo. Based on the similarity of SFN and its metabolites to the conserved structure of HDAC inhibitors, we have gone on to demonstrate that dietary consumption of SFN limits tumor growth in animal models and decreases HDAC activity in human volunteers. We propose to conduct a randomized placebo-controlled trial to test the effectiveness of supplemental SFN intake in improving biomarkers for prognosis in DCIS patients and in altering HDAC activity. The research proposed in this application is highly relevant because strategies that target epigenetic pathways have the potential to increase survival of DCIS patients, reduce health care costs associated with breast cancer, and improve the quality of life for thousands of American women. The successful completion of these smaller clinical studies will provide a strong scientific foundation for future large-scale human clinical intervention studies to combat breast cancer. These studies are also significant because of the potential to qualify or change recommendations for breast cancer patients and thereby increase their survival through simple dietary choices incorporating easily accessible and safe food products into a patient's diet.",132236,CDP,Chemo/Dietary Prevention Study Section,,2,208677,
7754062,R21,CA,5,,01/01/2010,12/31/2010,PA-06-351,5R21CA133365-02,,NCI:169400;,2010,NATIONAL CANCER INSTITUTE,,ITHACA,UNITED STATES,SOCIAL SCIENCES,22,872612445,US,NY,148502820,CORNELL UNIVERSITY ITHACA,"KENKEL, DONALD S;",1876502;,5R21CA133365,01/01/2009,12/31/2010,"21+ years old; Adoption; Adult; Affect; Analysis, Policy; Area; Behavior; Behavioral Genetics; Behavioral Research; Businesses; Cancer Control; Cancer Control Science; Cigarette; Consumption; Data; Data Set; Dataset; Eating; Ecological impact; Employee; Environmental Impact; Environmental Tobacco Smoke; Expenditure; Family; Food; Food Intake; Genetic Determinants of Behavior; Genetics, Behavioral; Goals; Grant; Health Benefit; Home; Home environment; Household; Human, Adult; Impact, Environmental; Individual; Industry; NCI; NCI Organization; National Cancer Institute; Non-smoker; Pattern; Perception; Policies; Policy Analyses; Policy Analysis; Politics; Price; Public Health; Reaction; Research; Restaurants; Sampling; Smoke; Smoker; Smoking; Smoking Behavior; Survey Instrument; Surveys; Time; Tobacco Consumption; Tobacco use; Visit; adult human (21+); behavior genetics; consumer behavior; convenience food; environmental tobacco smoke exposure; fast food; food consumption; innovate; innovation; innovative; meetings; nonsmoker; novel; prevent; preventing; pricing; psychosocial; public health medicine (field); public health relevance; public policy on tobacco; reduce tobacco use; second hand smoke; tobacco control; tobacco control policy; tobacco policy",Econometric Study of the Impact of Smoking Bans on Consumer Behavior," Project Narrative Restaurant smoking bans are intended to reduce secondhand smoke exposure for both the customers and employees of restaurants, and they might also discourage smoking more generally. The public health impact of the bans depends partly on their impact on smokers' and nonsmoker's consumption of restaurant food. The proposed project will conduct an integrated study of the impact of the bans on consumer behavior.",133365,ZRG1,Special Emphasis Panel,,2,169400,
7760525,R21,CA,5,,02/01/2010,01/31/2011,PA-06-303,5R21CA137429-02,,NCI:169950;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,ANESTHESIOLOGY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"LIU, BIN ;",7041694;,5R21CA137429,02/01/2009,01/31/2011,"ATGN; Address; Affinity; Antibodies; Antigenic Determinants; Antigens; Area; Artifacts; Bacteriophages; Binding; Binding (Molecular Function); Binding Determinants; Body Tissues; Cancer Staging; Carbohydrates; Carcinoma in Situ; Carcinoma, Intraepithelial; Carcinoma, Preinvasive; Cell Communication and Signaling; Cell Line; Cell Line, Tumor; Cell Lines, Strains; Cell Signaling; Cell Surface Antigens; Cell surface; CellLine; Cells; Chemistry; Clinical; Complex; Detection; Development; Diagnostic Neoplasm Staging; Disease; Disorder; Early Diagnosis; Epitopes; Future; Generalized Growth; Genomics; Growth; Hu-mABs; Human; Human, General; Image; Immune Surveillance; Immunologic Surveillance; Immunological Surveillance; In Situ; In Vitro; Intracellular Communication and Signaling; Libraries; Man (Taxonomy); Man, Modern; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Moab, Clinical Treatment; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monoclonal Antibodies; Morphologic artifacts; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Outcome; PC3 cell line; Pancreas Neoplasms; Pancreatic Tumor; Phage Display; Phages; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Property; Property, LOINC Axis 2; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Research; Research Specimen; Scheme; Science of Chemistry; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Specimen; Staging; Structure; Surface; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Surveillances, Immunologic; Surveillances, Immunological; T-Stage; Techniques; Tissue Growth; Tissues; Tumor Antigens; Tumor Biology; Tumor Cell; Tumor Cell Line; Tumor Cell Migration; Tumor Pathology; Tumor Staging; Tumor Tissue; Tumor of the Pancreas; Tumor stage; Tumor-Associated Antigen; Tumors; Variant; Variation; anticancer research; bacterial virus; base; biological signal transduction; cancer metastasis; cancer progression; cancer research; conformation; conformational state; cultured cell line; design; designing; disease diagnosis; disease/disorder; early detection; experiment; experimental research; experimental study; gene product; human monoclonal antibodies; imaging; immunogen; improved; in situ cancer; laser capture microdissection; mRNA Expression; member; molecular imaging; neoplasia; neoplasm progression; neoplastic; neoplastic cell; neoplastic growth; neoplastic progression; novel; ontogeny; pancreatic neoplasm; prostate cancer cell line; public health relevance; receptor mediated endocytosis; research study; therapeutic target; tumor; tumor progression; tumor-specific antigen",Selection of internalizing human antibodies targeting pancreatic tumor cells in s," Project narrative This project aims to identify by laser capture microdissection internalizing human single chain antibodies that target pancreatic tumor cells in situ. These internalizing scFvs can be used to develop non-invasive imaging strategies that allow sensitive and accurate early tumor detection, and targeted therapies based on intracellular delivery strategies.",137429,CII,Cancer Immunopathology and Immunotherapy Study Section,,2,169950,
7764660,R21,DA,5,,02/01/2010,01/31/2011,PA-06-181,5R21DA023163-02,,NIDA:190387;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,DENTISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"SPIGELMAN, IGOR ;",1963060;,5R21DA023163,02/15/2009,01/31/2011,"2-arachidonoyl-glycerol; 2-arachidonoylglycerol; 2-arachidonyl-glycerol; 2-arachidonylglycerol; 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-; 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-; 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)-; 5,8,11,14-eicosatetraenoylethanolamide; Accounting; Acute; Adverse effects; Affect; Afferent Neurons; Agonist; Ammon Horn; Ammonium; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Analgesics, Opioid; Animals; Anochlesia; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Assay; Basal Ganglia; Basal Nuclei; Bioassay; Biologic Assays; Biological Assay; Blood - brain barrier anatomy; Blood-Brain Barrier; Body Tissues; Brain; Cannabinoids; Cannabinoids, Endogenous; Catalepsy; Cells; Central Nervous System; Central gray substance of midbrain; Cerebellum; Charge; Chung model; Closure by Ligation; Cognitive; Common Rat Strains; Cornu Ammonis; Data; Development; Drugs; Effectiveness; Encephalon; Encephalons; Endocannabinoids; Engineering; Engineerings; Exhibits; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Head; Hemato-Encephalic Barrier; Hippocampus; Hippocampus (Brain); Human; Human, General; Hyperalgesia; Hyperalgesic Sensations; Hypothermia; Immunocompetent; In Vitro; Indenes; Indoles; Laboratories; Learning; Legal; Ligands; Ligation; Lipids; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Medical; Medication; Memory; Mesencephalic Central Gray; Methods and Techniques; Methods, Other; Midbrain Central Gray; Modeling; Modification; N arachidonoyl 2 hydroxyethylamide; N-(2-hydroxyethyl)arachidonamide; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurons, Afferent; Neurons, Sensory; Neuropathy; Opioid; Opioid Analgesics; PNS Diseases; Pain; Painful; Parents; Penetration; Periaqueductal Gray; Peripheral; Peripheral Nerve Diseases; Peripheral Nervous System Diseases; Peripheral Nervous System Disorders; Peripheral Neuropathy; Peripheral nerve injury; Permeability; Persistent pain; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Physiologic; Physiological; Pilot Projects; Plants; Plants, General; Population; Property; Property, LOINC Axis 2; Public Health; R01 Mechanism; R01 Program; RPG; Radioactive; Rat; Rattus; Receptor Activation; Receptor Protein; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Screening procedure; Sensory Cell Afferent Neuron; Site; Source; Spinal; Spinal Nerves; Spinal nerve structure; Structure; Symptoms; System; System, LOINC Axis 4; Tail; Task Performances; Techniques; Testing; Therapeutic; Therapeutic Intervention; Thermal Hyperalgesias; Tissues; Transmission; Treatment Side Effects; allodynia; analgesia; analog; anandamide; anandamide (20.4,n-6); annulus of the aqueduct; arachidonoyl ethanolamide; arachidonoylethanolamide; arachidonylethanolamide; base; cannabinoid receptor; chronic neuropathic pain; chronic pain; chronic painful condition; design; designing; dorsal horn; drug/agent; hippocampal; hyperalgia; hypothermia, natural; in vitro Assay; intervention therapy; member; midbrain central gray substance; natural hypothermia; neuropathic; neuropathic pain; novel; painful neuropathy; periaqueductal gray matter; pilot study; public health medicine (field); public health relevance; receptor; screening; screenings; side effect; social; therapy adverse effect; tool; transmission process; treatment adverse effect",Development of Peripherally-acting Cannabinoid 1 Receptor Ligands," Project narrative: Relevance to Public Health  Neuropathic pain is extremely difficult to treat, in part because available drugs carry a high burden of central nervous system side-effects. Here we propose to design and test analogs of cannabinoid receptor ligands that are unable to cross the blood-brain barrier by virtue of their being charged compounds. As a result, we expect these drugs to exhibit analgesic properties with minimal psychotropic side-effects.",23163,SCS,Somatosensory and Chemosensory Systems Study Section,,2,190387,
7779400,R21,DA,5,,03/01/2010,02/28/2011,PA-06-319,5R21DA023489-02,,NIDA:213564;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"DUNLAP, LAURA J.;",8740338;,5R21DA023489,03/01/2009,02/28/2011,"3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-; Accounting; Active Follow-up; Adanon; Affect; Althose; Analysis, Cost; Analysis, Data; Au element; Care, Health; Characteristics; Code; Coding System; Collection; Cost Analyses; Cost Analysis; Data; Data Analyses; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Dolophine; Drug abuse; Drugs; Ensure; Environment; Evaluation; Evaluation Research; Expenditure; Funding Agency; Funding Source; Gold; Government Agencies; Health; Health Care Providers; Health Personnel; Healthcare; Healthcare Providers; Healthcare worker; Human; Human, General; Internet; Intervention; Intervention Strategies; Investigators; Investments; Lead; Mails; Man (Taxonomy); Man, Modern; Measurement; Medication; Methadone; Methadose; Method LOINC Axis 6; Methodology; Methods; On-Line Systems; Online Systems; Outcome; Outcome Measure; PROV; Paper; Patients; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Policy Maker; Preparation; Printing; Process; Programs (PT); Programs [Publication Type]; Provider; Questionnaires; Records; Reporting; Research; Research Personnel; Research Resources; Research, Evaluation; Researchers; Resource Allocation; Resources; Respondent; Risk; SAMHSA; Sampling; Services; Substance Abuse and Mental Health Services Administration; Substance Abuse and Mental Health Services Administration (U.S.); Substance abuse problem; Survey Instrument; Survey Method; Survey Methodology; Surveys; System; System, LOINC Axis 4; Time; Training; Treatment Cost; Treatment Effectiveness; United States Substance Abuse and Mental Health Services Administration; Validation; WWW; abuse of drugs; abuse of substances; abuses drugs; clinical data repository; clinical data warehouse; cost; cost effectiveness; data repository; design; designing; drug/agent; experiment; experimental research; experimental study; follow-up; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; improved; instrument; interventional strategy; medical personnel; online computer; programs; public health relevance; relational database; research study; response; service utilization; substance abuse; treatment program; treatment provider; web; web based; world wide web",Evaluation of a Web-based Instrument for Service-Level Cost Estimation in Drug Ab,,23489,NIDA,Neuropharmacology Research Subcommittee,,2,213564,
7649443,R21,DA,5,,02/01/2010,01/31/2011,PA-06-181,5R21DA024228-02,,NIDA:210128;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"KRYSTAL, JOHN H;",1863201;,5R21DA024228,07/01/2008,01/31/2011,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; AOD use; Abbreviations; Abuse, Cocaine; Active Follow-up; Addiction, Cocaine; Affect; Alcohol or Other Drugs use; Animals; Brodmann's area; Build-it; Cerebrovascular Circulation; Cocaine; Cocaine Abuse; Cocaine Dependences; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Comorbidity; Crime; D1 receptor; D2 receptor; DRD2; DRD2 Receptor; Data; Dependence; Dependences, Cocaine; Diagnosis; Disease; Disorder; Disturbance in cognition; Doctor of Philosophy; Dopamine; Dopamine D1 Receptor; Dopamine D2 Receptor; Drugs; Dysfunction; Frequencies (time pattern); Frequency; Frontal gyrus; Functional Magnetic Resonance Imaging; Functional disorder; HOSP; History; Hospitalization; Human; Human, General; Hydroxytyramine; Impaired cognition; Impairment; Impulsive Behavior; Independent Living; Individual; Inferior; Inferior Frontal Convolution; Inferior frontal gyrus; Jail; Knowledge; LBUL; Life; Light; Living, Independent; Lobule; MRI, Functional; Magnetic Resonance Imaging, Functional; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Measures; Medial; Medication; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Modeling; Monkeys; Nature; Outcome; Parietal; Patients; Pattern; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Photoradiation; Physiologic; Physiological; Physiopathology; Prefrontal Cortex; Property; Property, LOINC Axis 2; Psychiatrist; Psychoses; Psychotic Disorders; Public Health; QOL; Quality of life; Recording of previous events; Relative; Relative (related person); Research Resources; Resources; Risk; Schizophrenia; Schizophrenic Disorders; Severities; Short-Term Memory; Symptoms; Testing; Validation; Work; base; blood oxygen level dependent; cerebral blood flow; cerebral circulation; cerebrocirculation; cocaine use; cognitive dysfunction; cognitive function; cognitive loss; cognitive neuroscience; cognitively impaired; dementia praecox; design; designing; disability; disease/disorder; drug/agent; fMRI; follow-up; in vivo; interest; novel; pathophysiology; pre-clinical; preclinical; psychostimulant; public health medicine (field); public health relevance; receptor function; response; schizophrenic; substance use; working memory",The Interactive Impact of Cocaine and Schizophrenia on Prefrontal Function,,24228,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,210128,
7626480,R21,DA,5,,02/01/2010,01/31/2011,PA-06-181,5R21DA024388-02,,NIDA:223256;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW HAVEN,UNITED STATES,PSYCHIATRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"ESTERLIS, IRINA ;",10218800;,5R21DA024388,06/01/2008,01/31/2011,"Abstinence; Antibodies; Binding; Binding (Molecular Function); Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Brain imaging; Cholinergic Agonists, Nicotinic; Dependence, Nicotine; Dose; Encephalon; Encephalons; Ensure; Hemato-Encephalic Barrier; Human; Human, General; Image; Immunization, Booster; Immunization, Secondary; Individual; Life; Mammals, Rodents; Man (Taxonomy); Man, Modern; Measures; Medical Imaging, Single Photon Emission Computed Tomography; Molecular Interaction; Nervous System, Brain; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Nicotinic Acetylcholine Receptors; Nicotinic Agonists; Nicotinic Receptors; Participant; Pathway interactions; Prevention; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Questionnaires; Radionuclide Tomography, Single-Photon Emission-Computed; Residual; Residual state; Rewards; Rodent; Rodentia; Rodentias; SPECT; SPECT imaging; Scanning; Secondary Immunization; Smoke; Smoker; Smoking; Tobacco smoking; Tomography, Emission-Computed, Single-Photon; Vaccinated; Vaccination; Vaccines; Visual; Withdrawal Symptom; addiction; analog; base; booster vaccination; brain visualization; craving; experience; imaging; nicotine addiction; pathway; preclinical study; satisfaction; vaccine development",Nicotine Vaccine & Nicotine Occupancy of Brain Nicotinic Receptors,,24388,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,223256,
7772359,R21,DA,5,,02/01/2010,01/31/2011,PA-06-181,5R21DA024765-02,,NIDA:222750;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,COLUMBUS,UNITED STATES,NONE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"AHIJEVYCH, KAREN L;",1910356;,5R21DA024765,03/01/2009,01/31/2011,"2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-; 21+ years old; 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-; 6-Propyl-2-Thiouracil; Abstinence; Addiction, Drug; Address; Adherence; Adherence (attribute); Adult; Area; CDC; Carbon Monoxide; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Cessation of smoking; Characteristics; Chemical Dependence; Cigarette Smoker; Clinical; Clinical effectiveness; Cotinine; Country; Data; Dependence, Drug; Development; Disease; Disorder; Drug Addiction; Drug Dependency; Drug Therapy; Drugs; Experimental Designs; FLR; Failure (biologic function); General Population; General Public; Gustation; Human, Adult; Individual; Individual Differences; Inhalators; Inhaler; Institute of Medicine; Institute of Medicine (U.S.); Knowledge; Lead; Measurement; Measures; Medication; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Mission; Monitor; NAS/IOM; NIDA; National Institute of Drug Abuse; Nicotine; Nicotine Inhaler; Nicotine Replacement Therapy; Nicotrol Inhaler; Oral; Outcome; Participant; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Policies; Population; Prevention; Procedures; Process; Propylthiouracil; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Randomized; Reporting; Research; Risk Factors; Sampling; Scotine; Sensory; Smoke; Smokeless Nicotine Inhaler; Smoker; Smoking; Smoking Status; Stratification; Taste; Taste Perception; Techniques; Testing; Tobacco; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; adult human (21+); base; cease smoking; cigarette smoking; disease/disorder; drug/agent; experience; experiment; experimental research; experimental study; failure; heavy metal Pb; heavy metal lead; improved; nicotine replacement; public health relevance; randomisation; randomization; randomly assigned; reduce tobacco use; research study; smoke cigarette; smoking cessation; smoking prevalence; social stress; success; therapy adherence; tobacco control; treatment adherence",Bitter taste phenotype as a risk factor of oral nicotine replacement nonadherence," Project Narrative It is critical to reduce the 45 million cigarette smokers in the United States and smoking cessation pharmacotherapy doubles or triples one s chances of successful quitting. However, these products such as oral nicotine replacement therapies are not fully utilized with one potential factor being whether the smoker is a bitter taster or non-taster of bitter. Since nicotine contained in oral nicotine replacement medication has a bitter taste and 70% of the population taste bitter, using a simple technique in the clinical setting to match an individual s bitter taste type to appropriate nicotine or non-nicotine smoking cessation medications may be relevant to increase smoking cessation success.",24765,RPIA,"Risk, Prevention and Intervention for Addictions Study Section",,2,222750,
7754131,R21,DA,5,,01/01/2010,12/31/2010,PA-06-181,5R21DA024769-02,,NIDA:182531;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LINCOLN,UNITED STATES,PSYCHOLOGY,01,555456995,US,NE,685880430,UNIVERSITY OF NEBRASKA LINCOLN,"WIEBE, SANDRA A.;",9082129;,5R21DA024769,01/01/2009,12/31/2010,"0-11 years old; 1-5 years old; 3 year old; AD/HD; ADHD; Address; Affect; Age; Aggression; Aggressive behavior; Anxiety; Arts; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavior; Behavior Control; Behavior Disorder, Disruptive; Behavioral Manipulation; Biochemical; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Child Development; Child Youth; Child, Preschool; Childhood; Children (0-21); Clinical; Cognitive; Conduct Disorder; Development; Diagnosis; Disease; Disorder; Disruptive Behavior Disorder; Dose; Dysfunction; Emotional; Emotions; Enrollment; Exposure to; Fetal Alcohol Exposure; Fetal ETOH Exposure; Fetal Ethanol Exposure; Fetal Smoke Exposure; Functional disorder; Funding; Gestation; Gestational cigarette smoke exposure; Goals; Health Campaign; Home; Home environment; Human, Child; Hyperactive behavior; Hyperactivity; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperactivity, Motor; Hyperkinesia; Hyperkinesis; Hyperkinetic Movements; Hyperkinetic Syndrome; Impulsivity; In Utero Alcohol Exposure; In Utero ETOH Exposure; In Utero Ethanol Exposure; Individual Differences; Infant; Infant and Child Development; Informal Social Control; Intervention; Intervention Strategies; Laboratories; Link; Low Birth Weight Infant; Measures; Mediating; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods; Modeling; Nervous; Nicotine; Outcome; Parenting; Parenting behavior; Pathway interactions; Perinatal; Physiopathology; Pregnancy; Premature Birth; Prenatal Alcohol Exposure; Prenatal ETOH Exposure; Prenatal Ethanol Exposure; Prenatal Tobacco Smoke; Preschool Child; Preterm Birth; Preventive Intervention; Problem behavior; Process; Psychopathology; Public Health; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Regulation; Relative; Relative (related person); Reporting; Research; Risk; Risk Factors; Sampling; School-Age Population; Self Regulation; Short-Term Memory; Smoker; Social Control, Informal; Source; System; System, LOINC Axis 4; Time; Tobacco; Tobacco smoke; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; VLBW (human); Woman; abnormal psychology; alcohol-exposed pregnancy; attention deficit hyperactive disorder; behavioral control; behavioral problem; children; clinical relevance; clinically relevant; cohort; disease/disorder; disruptive behavioral disorder; early childhood; emotion regulation; enroll; executive control; executive function; experience; exposed to alcohol prenatally; externalizing behavior; fetal tobacco exposure; gestation ETOH exposure; gestation alcohol exposure; gestation ethanol exposure; improved; in utero; inattention; inattentiveness; indexing; interventional strategy; low birth weight infant human; low birthweight; maternal cigarette smoking; maternal smoking; neural; neurotoxic; nicotine use in pregnancy; pathophysiology; pathway; pediatric; peer; postnatal; pregnancy ETOH exposure; pregnancy alcohol exposure; pregnancy ethanol exposure; pregnant cigarette smoker; pregnant smoker; premature childbirth; premature delivery; prenatal cigarette smoking; prenatal exposure; prenatal nicotine exposure; prenatal tobacco exposure; prenatally alcohol exposed; prenatally exposed; prenatally exposed to alcohol; prenatally tobacco exposed; preschool child (1-5); preterm delivery; preventional intervention strategy; prospective; public health medicine (field); public health relevance; relating to nervous system; response; school age; skills; three year old; tobacco exposure; tobacco use in pregnancy; tool; working memory; youngster","Prenatal Tobacco Exposure, Self Regulation, and Externalizing Behaviors in Early "," Prenatal tobacco exposure (PTE) affects more than 500,000 infants per year, and has been linked to increased disruptive behavior in young children (Day, 2000; Wakschlag, 2006a). This project will examine the mechanisms underlying this link by examining self-regulation, or the ability to control behavior and emotions in prenatally tobacco-exposed and non-exposed preschool children. Understanding the specific deficits associated with PTE will drive development of targeted interventions for at-risk preschoolers, and improve public health efforts to assist women smokers to quit during pregnancy.",24769,ZRG1,Special Emphasis Panel,,2,182531,
7758801,R21,DA,5,,01/01/2010,12/31/2010,PA-07-309,5R21DA024966-02,,NIDA:222846;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,RESEARCH TRIANGLE PARK,UNITED STATES,,04,004868105,US,NC,277092194,RESEARCH TRIANGLE INSTITUTE,"KRAL, ALEXANDER H;",6781453;,5R21DA024966,01/15/2009,12/31/2010,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Attitude; Caring; Communities; Country; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Collection; Development; Disease Frequency Surveys; Feasibility Studies; Future; Goals; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; India; Injecting drug user; Injection Drug User; International; Intervention; Intervention Strategies; Intervention Trial; Interview; Investigation; Investigators; LAV-HTLV-III; Law Enforcement; Lead; Link; Location; Lymphadenopathy-Associated Virus; Methods; NIDA; National Institute of Drug Abuse; Needles; Outcome; PROV; Pb element; Personal Satisfaction; Pharmaceutical Services; Pharmacies; Pharmacists; Pharmacy facility; Policies; Policy Maker; Preparation; Preventive Intervention; Provider; Public Health; Public Health Service; Public Health Service (U.S.); Randomized; Research; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Sales; San Francisco; Services; Services, Pharmaceutic; Services, Pharmacy; Site; Sterility; Syringes; Testing; Training; Transmission; USPHS; United States; United States Public Health Service; Viet Nam; Vietnam; Vietnam, Republic of; Virus-HIV; Work; base; control trial; effective intervention; heavy metal Pb; heavy metal lead; improved; informant; interventional strategy; prevention service; preventional intervention strategy; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; response; social role; sterile; transmission process; well-being",International Feasibility Study of Pharmacy-based HIV Prevention: San Francisco," PROJECT NARRATIVE This research seeks to provide evidence supporting an expanded role for pharmacists as public health practitioners in the realm of HIV prevention for injection drug users globally, going beyond mere sales to customer engagement aimed at improved well-being. The public's health will benefit from this study in that the outcome will facilitate the development of partnerships between pharmacists, clinicians, and other public health service providers that provide HIV prevention services to injection drug users in resource-poor settings. Findings could lead to increased access to HIV care and treatment, as well as reduced HIV risk and secondary transmission.",24966,ZRG1,Special Emphasis Panel,,2,222846,
7797624,R21,DA,5,,01/01/2010,12/31/2010,PA-06-181,5R21DA024986-02,,NIDA:192810;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CAMBRIDGE,UNITED STATES,,08,043397520,US,MA,02138,"ABT ASSOCIATES, INC.","SELIGMAN, BARBARA ;",10384741;,5R21DA024986,01/01/2009,12/31/2010,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adopted; Attitude; Blood; Caring; Censuses; Characteristics; Communities; Country; Data; Data Collection; Drug usage; Elements; Environment; Epidemic; Feasibility Studies; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Health Services; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; India; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; International; Intervention; Intervention Strategies; Intervention Trial; Interview; Investigators; LAV-HTLV-III; Law Enforcement; Learning; Legal; Link; Location; Lymphadenopathy-Associated Virus; Method LOINC Axis 6; Methodology; Methods; Needles; Outcome Measure; Pharmaceutical Services; Pharmacies; Pharmacists; Pharmacy facility; Policies; Policy Maker; Population; Preparation; Public Health; Randomized; Research Personnel; Researchers; Reticuloendothelial System, Blood; Risk; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Sampling; Services; Services, Pharmaceutic; Services, Pharmacy; Site; Sterility; Survey Instrument; Surveys; Syringes; Testing; Training; Transmission; Viet Nam; Vietnam; Vietnam, Republic of; Virus; Virus-HIV; Viruses, General; WHO; Work; World Health Organization; base; communicable disease transmission; control trial; disease transmission; drug use; effective intervention; health care service; infectious disease transmission; informant; innovate; innovation; innovative; interventional strategy; multi-site trial; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; response; scale up; social; sterile; transmission process; willingness","Feasibility of Pharmacy-Based HIV Interventions among IDUs: Ha Giang, Vietnam"," Project Narrative This project is highly relevant to public health in that it will help to develop innovative, replicable, and sustainable HIV prevention and care interventions for injection drug users. In many developing and transitional countries there are growing HIV epidemics that are concentrated among IDUs but there are few scaled-up interventions to reach this important population. The interventions to be developed through project will utilize pharmacies, which are the most widespread settings for health services in the world.",24986,ZRG1,Special Emphasis Panel,,2,192810,
7763258,R21,DA,5,,02/01/2010,01/31/2011,PA-07-309,5R21DA025010-02,,NIDA:230776;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,BOSTON,UNITED STATES,,08,072366156,US,MA,02215,FENWAY COMMUNITY HEALTH CENTER,"CASE, PATRICIA L;",1985236;,5R21DA025010,02/15/2009,01/31/2011,"AIDS Virus; AIDS prevention; AIDS/HIV prevention; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Adopted; Area; Attitude; Availability of Health Services; Blood; Boston; Cities; City of Boston; Communities; Country; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; Data; Data Collection; Development; Disease Frequency Surveys; Drug usage; Elements; Environment; Epidemic; Feasibility Studies; Future; Goals; HCV Transmission; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Health Services Accessibility; Hepatitis C Transmission; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; India; Injecting drug user; Injection Drug User; Injection of therapeutic agent; Injections; International; Intervention; Intervention Strategies; Intervention Trial; Interview; Investigation; Investigators; LAV-HTLV-III; Law Enforcement; Learning; Link; Location; Lymphadenopathy-Associated Virus; Method LOINC Axis 6; Methodology; Methods; Needles; Neighborhoods; New England; Northeastern United States; Outcome Measure; Pattern; Pharmaceutical Services; Pharmacies; Pharmacists; Pharmacy facility; Policies; Policy Maker; Preparation; Public Health; Randomized; Research Personnel; Researchers; Reticuloendothelial System, Blood; Risk; Risk Behaviors; Risky Behavior; Russia; Russian Federation (Europe); Russian S.F.S.R.; Russian SFSR; Sales; Sampling; Services; Services, Pharmaceutic; Services, Pharmacy; Site; Sterility; Survey Instrument; Surveys; Syringes; Testing; Training; Transmission; Viet Nam; Vietnam; Vietnam, Republic of; Virus; Virus-HIV; Viruses, General; WHO; Work; World Health Organization; access to services; access to treatment; at risk behavior; availability of services; base; communicable disease transmission; control trial; density; disease transmission; drug use; effective intervention; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; infectious disease transmission; informant; interventional strategy; multi-site trial; public health medicine (field); public health relevance; randomisation; randomization; randomized trial; randomly assigned; response; social; sterile; transmission process; willingness",Feasibility of Pharmacy-Based HIV Interventions among IDUs: 2 New England Cities," The purpose of this study is to assess the feasibility of using pharmacies as public health venues to provide HIV-related services to injection drug users in U.S. and international settings in preparation for a large-scale, multi-site randomized controlled intervention trial. This is one of five linked R21 proposals. Each study will assess the feasibility of using their site for a future trial and all sites will contribute data to a Coordinating Center for a cross-site assessment. The overarching public health goal of this proposal is to reduce injection related HIV and HCV transmission and risk behaviors through careful development and testing of a pharmacy-based intervention.",25010,ZRG1,Special Emphasis Panel,,2,230776,
7779399,R21,DA,5,,03/01/2010,02/28/2011,PA-06-319,5R21DA025139-02,,NIDA:177293;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PULLMAN,UNITED STATES,MISCELLANEOUS,05,041485301,US,WA,99164,WASHINGTON STATE UNIVERSITY,"HILL, LAURA ;ROSENMAN, ROBERT EDWARD (contact);",8336415;9234555 (contact);,5R21DA025139,03/15/2009,02/28/2011,"Address; Affect; Analysis, Data; Care Givers; Caregivers; Characteristics; Communities; Community based prevention; Data; Data Analyses; Data Set; Dataset; Development; Econometric Models; Effectiveness, Program; Error Sources; Financial cost; Goals; Individual; Investigators; Knowledge; Measurement; Measures; Methods; Methods and Techniques; Methods, Other; Models, Econometric; Outcome; Parents; Participant; Policy Maker; Population; Predisposition; Prevention program; Program Effectiveness; Programs (PT); Programs [Publication Type]; Randomized; Research Personnel; Research Resources; Researchers; Resources; Risk Assessment; Sampling; Schools; Selection Bias; Source; Sources, Error; Survey Instrument; Surveys; Susceptibility; Techniques; Testing; Weight; Youth; Youth 10-21; base; community setting; evidence base; improved; innovate; innovation; innovative; intervention program; new approaches; novel approaches; novel strategies; novel strategy; programs; public health relevance; randomisation; randomization; randomly assigned; social; substance abuse prevention; trait; universal interventions; universal prevention; universal preventive interventions; universal preventive measure",Development of Econometric Models for Improved Estimation of Prevention Program B, PROJECT NARRATIVE The proposed project will provide new methods of estimating program benefits with greater accuracy. This will enable researchers to calculate whether the benefits of community-based prevention programs outweight their financial costs. Such knowledge is helpful to policy makers as they decide how to prioritize limited resources for social programs.,25139,NIDA,Neuropharmacology Research Subcommittee,,2,177293,
7777420,R21,DA,5,,01/01/2010,12/31/2010,PA-06-181,5R21DA025837-02,,NIDA:181395;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CHARLESTON,UNITED STATES,NEUROSCIENCES,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"ASTON-JONES, GARY S.;",1864154;,5R21DA025837,03/01/2009,12/31/2010,"5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-; Agonist; Animals; Antibodies; Arousal; Basic Research; Basic Science; Behavioral; Brain; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Clinical; Clozapine; Common Rat Strains; Coupled; Customized Drugs; Designer Drugs; Effectiveness; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Future; GFP; Gelineau Syndrome; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genes, Immediate-Early; Genetic Intervention; Genetic Materials; Goals; Green Fluorescent Proteins; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Health; Human; Human, General; Hypothalamic structure; Hypothalamus; Immediate-Early Genes; Infection; Injection of therapeutic agent; Injections; Intervention, Genetic; Label; Lateral; Lead; Lentiviral Vector; Lentivirus Vector; Mammals, Rats; Man (Taxonomy); Man, Modern; Materials, Genetic; Mediating; Methods; Microinjections; Molecular Biology, Gene Therapy; Narcolepsy; Narcoleptic Syndrome; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology - biologic function; Neurophysiology / Electrophysiology; Neurosciences Research; Oxides; Paroxysmal Sleep; Pb element; Peptides; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; Rat; Rattus; Receptor Protein; Regulation; Research; Rewards; Role; Site; Sleep Disorders; Staining method; Stainings; Stains; Subcellular Process; System; System, LOINC Axis 4; Technology; Therapy, DNA; Viral; Viral Diseases; Viral Vector; Virus; Virus Diseases; Viruses, General; addiction; cell type; experiment; experimental research; experimental study; gene product; gene therapy; genetic therapy; heavy metal Pb; heavy metal lead; hypocretin; hypocretin/orexin; hypocretins/orexins; hypothalamic; in vivo; nervous system disorder; neural function; neurological disease; neuronal; new technology; new therapeutics; next generation therapeutics; novel therapeutics; orexin; public health relevance; receptor; receptor expression; research study; selective expression; selectively expressed; sleep problem; social role; therapeutic development; tool; transfer of a gene; vector; viral infection; virus infection",Gene Transfer Into Selected Brain Neurons In Vivo," RELEVANCE The proposed research is relevant to human health because it will develop new tools for more selective and specific manipulation of genes in brain neurons. These new tools not only will be important for basic research into the functions of specific brain neurons with consequences for new therapeutic development, but will also lead the way for new clinical approaches in gene therapy for a large number of disorders of the nervous system. Given the roles of the orexin system in addiction and in sleep disorders, the specific method proposed will lead to new ways to control orexin neuron activity for treating addiction or sleep disorders such as narcolepsy.",25837,BRS,Biological Rhythms and Sleep Study Section,,2,181395,
7799278,R21,DA,5,,03/01/2010,02/28/2011,PA-07-334,5R21DA026513-02,,NIDA:122473;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LOS ANGELES,UNITED STATES,FAMILY MEDICINE,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"HEINZERLING, KEITH GREGORY;",8661481;,5R21DA026513,04/15/2009,02/28/2011,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; 21+ years old; AD/HD; ADHD; Active Follow-up; Address; Adolescent; Adolescent Youth; Adult; Adverse Experience; Adverse event; Amfebutamone; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Auditory Hallucination; Behavior; Behavior Therapy, Cognitive; Behavioral Therapy; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Bupropion; Characteristics; Clinical; Clinical Trials; Clinical Trials, Phase II; Clinical Trials, Unspecified; Clinical assessments; Cognitive Therapy; Complement; Complement Proteins; Crystal Meth; DNA; DNA Library; DNA bank; Data; Deoxyephedrine; Deoxyribonucleic Acid; Deposit; Deposition; Desoxyephedrine; Dose; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Drug Kinetics; Drug Therapy; Drugs; Emotional Depression; Enrollment; Feeling suicidal; Frequencies (time pattern); Frequency; Future; Genetic analyses; Hallucination, Auditory; History; Human, Adult; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; K23 Award; K23 Mechanism; K23 Program; Medication; Mental disorders; Mental health disorders; Mentored Patient-Oriented Research Career Development Award; Mentored Patient-Oriented Research Career Development Award (K23); Methamphetamine; Methamphetamine dependence; Methods; Methylamphetamine; Monitor; N-Methylamphetamine; PBO; Participant; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacogenomics; Pharmacokinetics; Pharmacotherapy; Phase 2 Clinical Trials; Phase II Clinical Trials; Pilot Projects; Placebos; Population; Prevalence; Procedures; Psychiatric Disease; Psychiatric Disorder; Psychotherapy, Cognitive; Public Health; Randomized; Recording of previous events; Recruitment Activity; Reporting; Research; Research Specimen; Respondent; Safety; Sampling; Severities; Sham Treatment; Specimen; Suicidal thoughts; Symptoms of depression; Therapy, Cognition; Unspecified Mental Disorder; Variant; Variation; Violence; adult human (21+); aged; attention deficit hyperactive disorder; buproprion; career; cigarette smoking; clinical investigation; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; contingency management; depressive; depressive symptoms; design; designing; drug/agent; effective therapy; enroll; follow-up; genetic analysis; juvenile; juvenile human; medication adherence; medication compliance; mental illness; methamphetamine abuse; novel; peer; phase 2 study; phase 2 trial; phase II trial; pilot study; pilot trial; protocol, phase II; psychological disorder; psychological distress; public health medicine (field); public health relevance; randomisation; randomization; randomized placebo controlled study; randomized placebo controlled trial; randomly assigned; recruit; response; sex risk; sham therapy; smoke cigarette; study, phase II; suicidal ideation; suicidal thinking; suicide ideation; thoughts about suicide; violent; violent behavior",Pilot Trial of Bupropion versus Placebo for Methamphetamine Abuse in Adolescents," Narrative/Relevance Methamphetamine (MA) abuse among adolescents is a significant public health problem that is associated with psychological distress, depressive symptoms, auditory hallucinations, suicidal ideation, and high rates of violent behavior and HIV-related sexual risk behaviors. No studies have examined pharmacotherapies for MA abuse among adolescents, and therefore studies to identify effective pharmacotherapies for adolescents with MA abuse are urgently needed. The proposed pilot study has significant public health relevance in that it will provide critical data required for the design and implementation of a full scale clinical trial of bupropion, a medication that has shown efficacy for MA dependence in adults, for MA abuse in adolescents.",26513,ZDA1,Special Emphasis Panel,,2,122473,
7752570,R21,DC,5,,01/08/2010,12/31/2010,PA-06-181,5R21DC008969-02,,NIDCD:209138;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,NEW YORK,UNITED STATES,PSYCHIATRY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"ZEVIN, JASON D;",7554000;,5R21DC008969,01/01/2009,12/31/2010,"21+ years old; Adult; Analysis, Data; Basic Research; Basic Science; Behavioral; Biological Neural Networks; Brain; Categories; Classification; Communication Disorders; Communication impairment; Communicative Disorders; Complex; Connectionist Models; Data; Data Analyses; Development; Dimensions; Disease; Disorder; Dyslexia; Encephalon; Encephalons; Event; Functional Magnetic Resonance Imaging; Goals; Human; Human, Adult; Human, General; Image; Impairment; Individual Differences; Judgment; Language; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Maps; Measures; Methods; Methods and Techniques; Methods, Other; Mining; Minings; Modality; Modeling; Multivariate Analyses; Multivariate Analysis; Nature; Nervous; Nervous System, Brain; Neural Network Models; Neural Network Simulation; Neural Networks (Computer); Pattern; Perception; Perceptrons; Phonetics; Play; Preparation; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Recovery; Research; Resolution; Role; Scanning; Series; Source; Speech; Speech Perception; Speech Sound; Stimulus; Systematics; Techniques; Testing; Training; Translational Research; Translational Research Enterprise; Translational Science; Variant; Variation; Word Blindness; adult human (21+); base; brain behavior; data acquisition; design; designing; disease/disorder; experiment; experimental research; experimental study; fMRI; imaging; insight; interest; language processing; neural; neural network; neural network (computer simulation of nervous system); neural patterning; neuroimaging; new approaches; novel; novel approaches; novel strategies; novel strategy; programs; public health relevance; relating to nervous system; research study; response; social role; specific language impairment; tool; translation research enterprise",Distributed Phonetic Representations in the Brain," Project Narrative If successful, the proposed research will provide a new set of analytic tools for the study of the neural basis of speech perception. These techniques will be applicable to research on adult processing, typical development, and a range of communication disorders -- including dyslexia and specific language impairment -- in which speech perception deficits may play a central role. Specifically, it will provide a means to better characterize individual differences in the representation of speech categories, and to explore more detailed hypotheses about the nature of deficits in different disorders than is possible with currently predominant techniques.",8969,LCOM,Language and Communication Study Section,,2,209138,
7772253,R21,DC,5,,02/01/2010,01/31/2011,PA-06-181,5R21DC009505-02,,NIDCD:188001;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"CHUN, JEROLD ;",1897385;,5R21DC009505,02/18/2009,01/31/2011,"AGR16 Protein; Address; Aging; Agonist; Assay; Attenuated; Auditory; Bioassay; Biologic Assays; Biological Assay; Biological Models; Cell Communication and Signaling; Cell Death; Cell Growth and Maintenance; Cell Maintenance; Cell Signaling; Cell Survival; Cell Viability; Cells; Cessation of life; Chemicals; Cochlea; Cochlear Hearing Loss; Cochlear Organ; Cochlear structure; Corti Cell; Cortis Organ; Data; Deafness; Death; Defect; Development; Drugs; EDG5 Protein; Ear, Internal; Edg Receptors; Edg-5 Receptor; Equilibrium; Equilibrium Hair Cell; Esthesia; Exposure to; Family; Florida; G Protein-Complex Receptor; G-Protein Coupled Receptor H218; G-Protein-Coupled Receptors; Genetic; Goals; H218 Protein; Hair Cells; Hair Cells, Vestibular; Hearing; Hearing Loss; Hypoacuses; Hypoacusis; Individual; Infection; Intracellular Communication and Signaling; Knock-out; Knockout; Knockout Mice; Laboratories; Labyrinth; Lead; Lipids; Maintenance; Maintenances; Mammals, Mice; Medication; Medicine; Mice; Mice, Knock-out; Mice, Knockout; Model System; Models, Biologic; Molecular Bank; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Natural regeneration; Neurosciences; Noise; Null Mouse; Organ of Corti; Organ of Corti structure; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Play; Prevention; Process; Receptor Protein; Receptor, S1P2; Regeneration; Research; Research Institute; Research Resources; Resources; Risk; Role; S1P Receptor; Science of Medicine; Screening procedure; Senescence; Sensation; Sensory Hair; Signal Transduction; Signal Transduction Systems; Signaling; Sphingosine-1-Phosphate Receptor; Spinning Sensation; Spiral Organ; Spiral Organ of Corti; Structure; System; System, LOINC Axis 4; Testing; United States National Institutes of Health; Validation; Vertigo; Vertigo, Subjective; Vestibular Hair Cells; Vibration; Vibration - physical agent; Work; age dependent; age related; balance; balance function; base; biological signal transduction; drug/agent; ear hair cell; hearing impairment; hearing perception; heavy metal Pb; heavy metal lead; high risk; inner ear; innovate; innovation; innovative; member; mouse model; necrocytosis; novel; prevent; preventing; public health relevance; receptor; regenerate; screening; screenings; senescence; senescent; small molecule; social role; sound perception; sphingosine 1-phosphate; therapeutic target; tool; vibration",Targeting S1P receptors to prevent hearing loss," Project Narrative Non-congenital hearing loss occurs when auditory hair cells die in the inner ear and can be caused by noise, infection, ototoxic medications or aging. Asymmetric hearing loss or death of vestibular hair cells can also lead to balance defects, such as vertigo. Currently there are no medicinal treatments for reversing hearing loss, and sensory hair cells do not regenerate. This proposal will study the function of a small lipid known as sphingosine 1-phosphate (S1P) in the inner ear. Loss of S1P signaling was recently shown to lead to degeneration of auditory and vestibular hair cells leading to hearing loss and disrupted balance in mice, suggesting S1P may play a protective role. Through a combination of neuroscience, genetics and pharmacology, this study aims to test the hypothesis that induced hearing loss can be prevented by pharmacological activation of specific S1P receptors. The goal of this research is to identify novel chemicals that can prevent hair cell loss that results from ototoxic drugs, or loud noise exposure in mouse models. Such findings may eventually lead to new medicines that could prevent hearing loss.",9505,ZRG1,Special Emphasis Panel,,2,188001,
7769460,R21,DC,5,,02/01/2010,01/31/2011,PA-06-278,5R21DC010074-02,,NIDCD:191194;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ANN ARBOR,UNITED STATES,PSYCHIATRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BURMEISTER, MARGIT ;",1893112;,5R21DC010074,02/12/2009,01/31/2011,"Affect; Animal Model; Animal Models and Related Studies; Ataxia; Ataxy; Auditory; Bio-Informatics; Bioinformatics; Biological Function; Biological Process; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chromosome Mapping; Complementary DNA; Complex; Coordination Impairment; DNA; DNA, Complementary; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deafness; Deoxyribonucleic Acid; Development and Research; Diagnosis; Disease; Disorder; Dyssynergia; Epilepsy; Epileptic Seizures; Epileptics; Exons; Familial disease; Family; Family Planning; Family Planning Services; Family Sizes; Foundations; Founder Effect; Future; Gene Chips; Gene Expression; Gene Expression Chip; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic analyses; Genetic defect; Genetics, Gene Mapping; Genome; Genomics; Genotype; Goals; Grant; Haplotypes; Hearing Disorders; Hearing problem; Heterogeneity; Individual; Intercept; Intervening Sequences; Intracellular Communication and Signaling; Introns; Lead; Link; Linkage (Genetics); Linkage Analysis; Linkage Disequilibrium; Linkage Disequilibriums; Linkage Mapping; Literature; Location; Longitudinal Studies; Maps; Merlin; Messenger RNA; Metabolic Pathway; Methods; Moesin-Ezrin-Radixin-Like Protein; Molecular; Mutate; Mutation; NF2 Gene Product; Neurofibromatosis 2 Gene Product; Neurofibromatosis Type 2 Protein; Neurofibromin 2; Neuropathy; Pathway interactions; Pattern; Pb element; Polymorphism (Genetics); Polymorphism, Genetic; Process; R & D; R&D; RNA, Messenger; Rare Diseases; Rare Disorder; Relative; Relative (related person); Research; Schwannomerlin; Schwannomin; Schwannomin Protein; Scientist; Seizure Disorder; Signal Transduction; Signal Transduction Systems; Signaling; Stretching; Testing; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Variant; Variation; biological signal transduction; cDNA; case control; clinical data repository; clinical data warehouse; data repository; disease/disorder; epilepsia; epileptiform; epileptogenic; familial disorder; family based linkage study; genetic analysis; genetic linkage; genetic linkage analyses; genetic linkage analysis; genetic mapping; genetic variant; genome mutation; hearing disease; heavy metal Pb; heavy metal lead; improved; linkage analyses; long-term study; lymphoblastoid cell line; mRNA; member; model organism; mutant; neuropathic; neurotechnology; novel; pathway; polymorphism; positional cloning; public health relevance; relational database; research and development; response; reverse genetics; tool",Comprehensive genomic approach to rare hearing disorders and ataxia," Narrative The genetic cause of many forms of deafness or ataxia is still unknown. Our research will result in the identification of new genes and metabolic pathways involved in these disorders. These findings can improve accurate diagnosis, presymptomatic testing, family planning and personalizing treatment. It may also ultimately lead to new treatments.",10074,GHD,Genetics of Health and Disease Study Section,,2,191194,
7761298,R21,DK,5,,02/01/2010,01/31/2011,PAR-06-113,5R21DK078714-02,,NIDDK:245768;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,NEW HAVEN,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"PARIKH, CHIRAG R;",8270841;,5R21DK078714,02/01/2009,01/31/2011,"72-kDa Gelatinase; 72-kDa Type IV Collagenase; 72kD type IV Collagenase; Accuracy of Diagnosis; Acute Kidney Failure; Acute Kidney Tubular Necrosis; Acute Renal Failure with Tubular Necrosis; Admission; Admission activity; Albumins; Animals; Azotemia; Basic Research; Basic Science; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Bleeding; Blood Pressure, Low; Blood flow; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cirrhosis; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cohort Studies; Complication; Concurrent Studies; Critical Illness; Critically Ill; Development; Diagnosis; Diagnosis, clinical; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Diarrhea; Differential Diagnosis; Diuresis; Diuretics; Dysfunction; Early treatment; Enrollment; Epidemiology; Exclusion; Excretory function; FLR; Failure (biologic function); Forecast of outcome; Functional disorder; Future; GI hemorrhage; Gastrointestinal Hemorrhage; Gelatinase A; Gelatinase Neutrophil; Glomerular disease; Grafting, Liver; Hemodialyses; Hemodialysis; Hemorrhage; Hepatic Disorder; Hepatorenal Syndrome; Human; Human, General; Hypertension, Portal; Hypotension; Hypovolemia; IFN-gamma-Inducing Factor; IGIF; IL-1 Gamma; IL-18; IL-1g; IL18 Protein; IL1F4; Injury; Institutes; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin-1 Gamma; Interleukin-18; Interleukin-18 Precursor; Investigators; Kidney; Kidney Diseases; Kidney Failure; Kidney Failure, Acute; Kidney Insufficiency; Kidney Insufficiency, Acute; Kidney Tubular Necrosis, Acute; Lead; Liver Transplant; Liver diseases; Lower Nephron Nephrosis; MGC12320; MMP-2; MMP2; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinase-2; Measures; Mice; Microscopy; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Na element; Nephropathy; Nephrotoxic; Oliguria; Oligurias; Osmolar Concentration; Osmolarity; Outcome; PEX; Patient Care; Patient Care Delivery; Patients; Pb element; Physicians; Physiopathology; Portal Hypertension; Process; Prognosis; Publications; Renal Disease; Renal Failure; Renal Failure, Acute; Renal Glomerular Diseases and Syndromes; Renal Insufficiency; Renal Insufficiency, Acute; Renal function; Renal glomerular disease; Renal glomerular disease or syndrome; Renal glomerular disorder; Renal glomerular syndrome; Research; Research Personnel; Research Resources; Researchers; Resources; Sampling; Scientific Publication; Sensitivity and Specificity; Sepsis; Sodium; Supportive Therapy; Supportive care; Surgical Procedures, Heart; Testing; Therapeutic; Training; Transplantation; Transplantation of liver; Transplantation, Hepatic; Tubular; Tubular formation; Urinary System, Kidney; Urinary System, Urine; Urine; Vascular Hypotensive Disorder; Vascular constriction (function); Vasoactive Agonists; Vasoconstriction; Vasoconstrictor Agents; Vasoconstrictor Drugs; Vasoconstrictors; Vasodilatation; Vasodilation; Vasopressor Agents; Vasorelaxation; acute tubular necrosis; base; biobank; biomarker; blood loss; bloodstream infection; clinical Diagnosis; clinical investigation; diagnostic accuracy; enroll; excretion; experience; failure; heart surgery; heavy metal Pb; heavy metal lead; hepatopathy; improved; kidney disorder; kidney function; liver disorder; liver transplantation; new diagnostics; next generation diagnostics; novel; novel diagnostics; outcome forecast; pathophysiology; preclinical study; prognostic; prospective; public health relevance; renal; renal disorder; statistics/biometry; tool; transplant; urinary; vasopressor",Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction," Renal failure in patients with hospitalized patients with cirrhosis is common and associated with a grave prognosis. Currently, there are few tools to distinguish between two major forms of renal failure in this setting, namely acute tubular necrosis and Type 1 Hepatorenal Syndrome. Urinary biomarkers, such as IL-18 and NGAL, which are valuable for identifying acute tubular necrosis in other clinical settings, will be tested in patients with renal failure and cirrhosis in this prospective cohort study.",78714,ZRG1,Special Emphasis Panel,,2,245768,
7762176,R21,DK,5,,01/01/2010,12/31/2010,PA-06-181,5R21DK081173-02,,NIDDK:241313;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,ENGINEERING (ALL TYPES),33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"NAYAK, KRISHNA S;",8026997;,5R21DK081173,02/01/2009,12/31/2010,"0-11 years old; 21+ years old; Abdomen; Abdominal; Abdominal Cavity; Abdominal obesity; Adipose tissue; Adolescent; Adolescent Youth; Adult; Affect; American; Android fat distribution; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animal Testing; Animals; Area; Au element; Autopsy; Back; Body Composition; Body Tissues; Body fat; Calibration; Cardiac Diseases; Cardiac Disorders; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cavitas abdominis; Cell Communication and Signaling; Cell Signaling; Central obesity; Centripetal obesity; Chemicals; Child; Child Youth; Children (0-21); Clinical; D-Glucose; Data; Development; Dextrose; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dorsum; Electromagnetic Radiation, Ionizing; Environment; Epidemic; Evaluation; Family suidae; Farm; Farming environment; Fat body with thin limbs; Fats; Fatty Liver; Fatty Tissue; Fatty acid glycerol esters; Gastrointestinal Tract, Pancreas; Glucose; Goals; Gold; H+ element; Health; Heart Diseases; Hepatic Disorder; Hour; Human; Human, Adult; Human, Child; Human, General; Hydrogen Ions; Hydrogen Oxide; Hyperlipemia; Hyperlipidemia; Image; Imaging Procedures; Imaging Techniques; Infiltration; Infrastructure; Insulin Resistance; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Investigators; Ionizing radiation; Link; Liver; Liver Steatosis; Liver diseases; Location; MODY; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetism; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metabolic; Methods; Methods and Techniques; Methods, Other; Metric; Modality; Modeling; Motion; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; NIDDM; NMR Imaging; NMR Tomography; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Magnetic Resonance Imaging; Obese face+trunk sparing limbs; Obesity; Obesity of face and trunk, sparing limbs; Organ; Organ System, Cardiovascular; Outcome; Pancreas; Pancreatic; Patients; Pigs; Procedures; Protocol; Protocols documentation; Protons; Radiation-Ionizing Total; Relative; Relative (related person); Research; Research Infrastructure; Research Personnel; Research Support; Researchers; Resolution; Risk; Risk Assessment; Scanning; Scheme; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Suidae; Swine; T2D; T2DM; Technics, Imaging; Techniques; Testing; Time; Tissues; Translational Research; Translational Research Enterprise; Translational Science; Truncal obesity; Type 2 diabetes; Type II diabetes; United States; Validation; Variant; Variation; Vascular, Heart; Visceral; Water; Zeugmatography; adipose; adiposity; adult human (21+); adult onset diabetes; base; biological signal transduction; body system, hepatic; cardiovascular disorder; children; circulatory system; corpulence; corpulency; corpulentia; cost; density; diabetes; disease/disorder; excess adiposity in midsection; heart disorder; hepatic steatosis; hepatopathy; imaging; imaging modality; improved; in vivo; innovate; innovation; innovative; insulin resistant; interest; interventional strategy; juvenile; juvenile human; ketosis resistant diabetes; liver disorder; magnetic; male-type obesity; maturity onset diabetes; model organism; necropsy; novel; novel therapeutic intervention; obese; obese people; obese person; obese population; organ system, hepatic; porcine; postmortem; public health relevance; rapid method; rapid technique; subcutaneous; suid; tool; translation research enterprise; trunk obesity; visceral obesity; waist-predominant obesity; white adipose tissue; yellow adipose tissue; youngster",Rapid MRI Measures of Absolute Fat Mass in Adipose Tissue and Organs," PROJECT NARRATIVE: Abdominal obesity is a growing problem among Americans, and is linked with increased risks of fatty liver disease, heart disease, and type-2 diabetes, among other things. This proposal will develop a new non-invasive test based on magnetic resonance imaging that determines the mass and location of fat within the abdomen, including critical organs, and may potentially be a useful tool in obesity research.",81173,ZRG1,Special Emphasis Panel,,2,241313,
7756676,R21,EB,5,,02/01/2010,01/31/2011,PA-06-418,5R21EB007821-02,,NIBIB:231642;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,DALLAS,UNITED STATES,MISCELLANEOUS,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"LU, HANZHANG ;",8101677;,5R21EB007821,02/01/2009,01/31/2011,"1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; Active Follow-up; Acute; Algorithms; Arteries; Arteriovenous Angioma; Arteriovenous Hemangioma; Arteriovenous malformation; Back; Blood; Blood Vessels; Blood Volume; Blood capillaries; Blood, Cord; Body Tissues; Brain; Caffeine; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Signaling; Cervical; Characteristics; Chest; Clinical Management; Complex; Contrast Agent; Contrast Drugs; Contrast Media; DETAPAC; DTPA; Data; Detarex; Diagnosis; Diethylenetriamine Pentaacetic Acid; Dimensions; Disease; Disorder; Dorsum; Dysfunction; Encephalon; Encephalons; Equilibrium; Evaluation; Extravasation; Functional disorder; Gadolinium; Gd element; Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-; Goals; Gray; Gray unit of radiation dose; H+ element; Human; Human, General; Hydrogen Ions; Image; Imaging Procedures; Imaging Techniques; Infarction; Ingestion; Intracellular Communication and Signaling; Intraspinal Neoplasm; Intraspinal Tumor; Investigation; Ischemia; Ischemic Myelopathy; Kinetic; Kinetics; Knowledge; Lead; Leakage; Lesion; Lumbar Portion of Spinal Cord; Lumbar Regions; Lumbar Spinal Cord; Lumbar spinal cord structure; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Man (Taxonomy); Man, Modern; Masks; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medulla Spinalis; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Motion; Myelopathy, Traumatic; NMR Imaging; NMR Tomography; Nervous System, Brain; Nuclear Magnetic Resonance Imaging; Outcome; Patients; Pb element; Pentaind; Pentetic Acid; Penthanil; Perfusion; Phase; Phlebothrombosis; Physicians; Physiologic; Physiological; Physiopathology; Protocol; Protocols documentation; Protons; Racemose Angioma; Racemose Hemangioma; Radiopaque Media; Recovery; Recovery of Function; Recruitment Activity; Regions, Lumbar; Reporting; Reproducibility; Research; Resolution; Reticuloendothelial System, Blood; SCI Patients; Signal Transduction; Signal Transduction Systems; Signaling; Spillage; Spinal; Spinal Artery; Spinal Canal; Spinal Canal Tumors; Spinal Canal and Spinal Cord Neoplasm; Spinal Column; Spinal Cord; Spinal Cord Diseases; Spinal Cord Disorders; Spinal Cord Ischemia; Spinal Cord Trauma; Spinal Neoplasms; Spinal Trauma; Spinal Tumors; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Spinal cord injury patients; Spine; Structure; Tablets; Technics, Imaging; Techniques; Testing; Thorace; Thoracic; Thorax; Time; Tissues; Trauma; Tumor of the Spinal Canal and Spinal Cord; Umbilical Cord Blood; Validity of Results; Vascular blood supply; Venous Thrombosis; Vertebral column; Weight; Work; Zeugmatography; backbone; balance; balance function; base; biological signal transduction; biomarker; blood supply; capillary; clinical applicability; clinical application; density; disease/disorder; experiment; experimental research; experimental study; fetal cord blood; follow-up; functional recovery; gray matter; heavy metal Pb; heavy metal lead; hemodynamics; imaging; improved; infarct; myelopathy; pathophysiology; public health relevance; recruit; research study; substantia alba; substantia grisea; tablet (pharmacologic); vascular; vascular supply; vertebral canal; white matter",Quantitative measurement of spinal cord perfusion in humans using MRI," Project Narrative This project will develop a technique that will allow physicians to evaluate the blood supply to the spinal cord. Being able to measure blood supply will help physicians with the diagnosis and treatment of several spinal cord diseases, including spinal cord injury, spinal cord ischemia, and spinal tumor.",7821,ZRG1,Special Emphasis Panel,,2,231642,
7778296,R21,EB,5,,03/01/2010,02/28/2011,PA-06-181,5R21EB008190-02,,NIBIB:237600;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,STANFORD,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"HARGREAVES, BRIAN ANDREW;",8487394;,5R21EB008190,03/01/2009,02/28/2011,"3-D Imaging; 3D imaging; Acceleration; Active Follow-up; Acute; Address; Artifacts; Blood Vessels; Bone Infection; Bone Injury; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cadaver; Cell Communication and Signaling; Cell Signaling; Chronic; Clinical; Clinical Research; Clinical Study; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Conventional X-Ray; Coxa; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Radiology; Diagnostic radiologic examination; EMI scan; FLR; Failure (biologic function); Fats; Fatty acid glycerol esters; Funding; Goals; Hip; Hip region structure; Hydrogen Oxide; Image; Image Reconstructions; Imaging Device; Imaging Procedures; Imaging Techniques; Imaging Tool; Imaging, Three-Dimensional; Implant; Infection; Injury; Intracellular Communication and Signaling; Knee; Lead; Lesion; Location; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Three Dimensional; Medical Imaging, X-Ray; Metals; Methods; Methods and Techniques; Methods, Other; Morphologic artifacts; Myelogram; Myelography; NMR Imaging; NMR Tomography; Necrosis; Necrotic; Nerve Root Compressions; Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Osteomyelitis; Patients; Pb element; Phase; Physiologic pulse; Pilot Projects; Population; Post-Operative; Postoperative; Postoperative Period; Pulse; R01 Mechanism; R01 Program; RPG; Radiography; Radiology, Diagnostic X-Ray; Reconstructions, Image; Recovery; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Roentgenography; Scanning; Signal Transduction; Signal Transduction Systems; Signaling; Slice; Spinal; Spinal Column; Spinal Nerve Roots; Spinal Roots; Spinal Stenosis; Spinal nerve root structure; Spine; Surgery, Unnecessary; Surgical; Surgical Interventions; Surgical Procedure; Surgical complication; System; System, LOINC Axis 4; Technics, Imaging; Techniques; Tendon structure; Tendons; Three-Dimensional Imaging; Time; Tomodensitometry; Tomography, Xray Computed; Unnecessary Surgery; Validation; Variant; Variation; Vertebral column; Water; Weight; Work; X-Ray Computed Tomography; X-Ray Imaging; X-Ray, Diagnostic; Zeugmatography; backbone; base; biological signal transduction; catscan; computed axial tomography; computerized axial tomography; computerized tomography; design; designing; failure; follow-up; heavy metal Pb; heavy metal lead; imaging; imaging modality; improved; in vivo Model; innovate; innovation; innovative; magnetic field; pilot study; prevent; preventing; public health relevance; reconstruction; soft tissue; success; surgery; validation studies; vascular",Magnetic Resonance Imaging Near Metallic Implants," Project Narrative Metallic implants are being used increasingly to treat chronic and acute injuries to the spine, hip and knee. Magnetic resonance imaging (MRI) is commonly used for evaluating orthopedic conditions, but fails near metallic implants due to severe magnetic field inhomogeneities caused by metal. This research project will develop complete 3D correction of metal-induced distortions to radically improve MRI near implants.",8190,ZRG1,Special Emphasis Panel,,2,237600,
7756672,R21,EB,5,,02/01/2010,01/31/2011,PA-06-181,5R21EB008483-02,,NIBIB:186800;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CINCINNATI,UNITED STATES,ENGINEERING (ALL TYPES),01,041064767,US,OH,45221,UNIVERSITY OF CINCINNATI,"MAST, T DOUGLAS ;",2110064;,5R21EB008483,02/01/2009,01/31/2011,"Ablation; Abscission; Accounting; Acoustic; Acoustics; Algorithms; Body Tissues; Boils; Bovine Species; Cancer Treatment; Cancers; Cattle; Cell Communication and Signaling; Cell Signaling; Clinical; Clotting; Coagulation; Coagulation Process; Data; Deposit; Deposition; Development; Diagnosis, Ultrasound; Echography; Echotomography; Excision; Extirpation; Family suidae; Feedback; Frequencies (time pattern); Frequency; Furuncles; Future; Goals; Heating; Hepatic Cancer; Histologic; Histologically; Histology; Image; Imaging technology; In Situ; In Vitro; Individual; Intracellular Communication and Signaling; Investigation; Liver; Location; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Malignant neoplasm of liver; Maps; Measurement; Measures; Medical Imaging, Ultrasound; Methods; Microbubbles; Microscopic; Modality; Modeling; Models, Statistical; Mortality; Mortality Vital Statistics; Necrosis; Necrotic; Outcome; Patients; Pattern; Pigs; Probabilistic Models; Public Health; Recurrence; Recurrent; Removal; Research; Resolution; Safety; Saline; Saline Solution; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Soft Tissue Neoplasms; Sonication; Source; Specific qualifier value; Specified; Statistical Models; Suidae; Surgical Removal; Swine; System; System, LOINC Axis 4; Temperature; Therapeutic; Thermal Ablation Therapy; Time; Tissue Viability; Tissues; Transplantation; Tumor of the Soft Tissue; Ultrasonic; Ultrasonic Imaging; Ultrasonics; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Viability, Tissue; acoustic imaging; anticancer therapy; attenuation; base; biological signal transduction; body system, hepatic; bovid; bovine; cancer therapy; clinical applicability; clinical application; cow; diagnostic ultrasound; experiment; experimental research; experimental study; imaging; imaging modality; improved; in vivo; liver cancer; malignancy; malignant liver tumor; minimally invasive; neoplasm/cancer; new technology; organ system, hepatic; physical model; porcine; pre-clinical; preclinical; public health medicine (field); public health relevance; research study; resection; sonogram; sonography; sound measurement; suid; thermal ablation; transplant; tumor; ultrasound; ultrasound imaging; ultrasound scanning",Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation," Relevance: Liver cancer, both primary and metastatic, is a major public health problem, accounting for the largest cancer- related mortality in the world, with only a small fraction of patients eligible for curative resection or transplantation. Minimally invasive and noninvasive ablation methods provide an important alternative but have significant problems with incomplete treatment, tumor recurrence, and complications caused by imprecise treatment. Ultrasound ablation is a particularly promising approach, potentially offering more precise and reliable treatment, but will not realize its full potential without effective feedback, control and image guidance. Our passive cavitation imaging technology has the potential to greatly improve guidance and control of minimally-invasive and noninvasive ultrasound tumor ablation, providing more precise, selective, predictable, and consistent ablation of liver cancer as well as soft tissue tumors and other clinically important targets, and thus fewer complications, reduced tumor recurrence, and improved patient outcomes.",8483,ZRG1,Special Emphasis Panel,,2,186800,
7759119,R21,EB,5,,02/01/2010,01/31/2011,PA-08-053,5R21EB009180-02,,NIBIB:220636;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,CAMBRIDGE,UNITED STATES,ENGINEERING (ALL TYPES),08,001425594,US,MA,02139,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,"KARNIK, ROHIT N;",9100263;,5R21EB009180,02/01/2009,01/31/2011,"Assay; Back; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Biological Models; Biology; Caliber; Care, Health; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Charge; Clinical Research; Clinical Study; Coulter counter; Cytometry; DNA; DNA Sequence; DNA Viruses; Deoxyribonucleic Acid; Detection; Development; Devices; Diagnostic; Diameter; Digestion; Dorsum; Event; Feedback; Fingerprint; Foundations; Genomics; Goals; Healthcare; Hemalysins; Hemolysin; Intracellular Communication and Signaling; Label; Laboratories; Length; Measurement; Methods and Techniques; Methods, Other; Microscopy; Miniaturisations; Miniaturization; Miniaturizations; Model System; Models, Biologic; Molecular; Molecular Interaction; Nanoscale Science; Nanosphere; Nanotechnology; Noise; Organelles; Physiologic pulse; Process; Proteins; Pulse; Research; Resolution; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Surface; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Techniques; Technology; Therapeutic; Time; V (voltage); Virus; Viruses, General; Work; base; biological signal transduction; biological systems; design; designing; gel electrophoresis; gene product; improved; lithography; nano channel; nano fabricate; nano fabrication; nano fluidic; nano meter scale; nano meter sized; nano particle; nano pore; nano scale; nano scale Science; nano sphere; nano tech; nano technology; nanochannel; nanofabricate; nanofabrication; nanofluidic; nanometer scale; nanometer sized; nanoparticle; nanopore; nanoscale; nanotech; new technology; particle; prevent; preventing; protein complex; public health relevance; sensor; single molecule; voltage",Nanofluidic system for analysis of single biological molecules and particles, Narrative In this project we will develop a nanofluidic system for sizing of large DNA fragments with a nanochannel sensor. This work may result in significant improvement in signal-to-noise ratios for label-free analysis of single biological particles and molecules in the nanoscale size range.,9180,ZRG1,Special Emphasis Panel,,2,220636,
7764683,R21,EB,5,,02/01/2010,01/31/2011,PA-06-181,5R21EB009196-02,,NIBIB:220275;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,BOSTON,UNITED STATES,,08,030811269,US,MA,02115,BRIGHAM AND WOMEN'S HOSPITAL,"KHADEMHOSSEINI, ALI ;",8531188;,5R21EB009196,02/01/2009,01/31/2011,"1,2-Ethanediol; 2-Hydroxyethanol; Address; Antibodies; Apoptosis; Apoptosis Pathway; Apoptotic; Articulation; Assay; Behavior; Bioassay; Biocompatible Materials; Biologic Assays; Biological; Biological Assay; Biomaterials; Cell Death, Programmed; Cells; Cells, Immobilized; Chemicals; Collaborations; Development; Devices; Diffusion; Dihydroxyethanes; Drugs; ELISA; Enzyme-Linked Immunosorbent Assay; Equipment; Ethanediols; Ethylene Glycols; Goals; HOSP; Health Sciences; High Throughput Assay; Hospitals; Hydrogels; Immobilized Cells; Individual; Investigators; Joints; Kinetic; Kinetics; Medication; Methods; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Microfluidic; Microfluidics; Molecular Bank; Monoethylene Glycol; Optics; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Printing; Procedures; Process; Proteins; Reading; Research; Research Personnel; Researchers; Robotics; Sampling; Schools, Medical; Slide; Spottings; Stimulus; Structure; Surface; System; System, LOINC Axis 4; Techniques; Technology; Testing; Time; Tissue Engineering; Woman; base; biological systems; cell behavior; chemical release; controlled release; design; designing; drug discovery; drug/agent; engineered tissue; ethylene glycol; gene product; high throughput analysis; high throughput screening; medical schools; member; microarray technology; multidisciplinary; nano engineering; nanoengineering; public health relevance; response; seal; small molecule libraries; tool",High-Throughput Analysis of Cell Response to Chemical Libraries, PROJECT NARRATIVE We aim to develop microarray systems incorporated with microwells for high-throughput analysis of cell response to chemical libraries.,9196,ISD,Instrumentation and Systems Development Study Section,,2,220275,
7769883,R21,ES,5,,02/01/2010,01/31/2011,PA-06-181,5R21ES014911-02,,NIEHS:136772;,2010,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES,,MONTREAL,CANADA,,,208572446,CA,PQ,H3T 1E2,SIR MORTIMER B. DAVIS JEWISH GEN HOSP,"MANN, KOREN K;",1949462;,5R21ES014911,02/13/2009,01/31/2011,"9-cis-Retinoic Acid Receptor; APOE [{C0003595}]; Activation, Gene; Active Oxygen; Adhesions; Apo-E; ApoE; Apolipoprotein E; Area; Arsenic; Arterial Fatty Streak; Arteries; Atheroma; Atheromatous; Atheromatous degeneration; Atheromatous plaque; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Blood Vessels; Cancer Causing Agents; Cancer Induction; Carcinogens; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cellular Expansion; Cellular Growth; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholesterol Homeostasis; Complement; Complement Proteins; Cytokines, Chemotactic; DNA Binding; DNA Binding Interaction; Data; Development; Dose; EC 2.7; Endothelial Cells; Environment; Environmental Pollution; Environmental Toxin; Exposure to; Family; Gene Activation; Gene Expression; Gene Targeting; Gene Transcription; Genetic Transcription; HDL; Hazards, Health; Health Hazards; Heavy Lipoproteins; Heterodimerization; High Density Lipoproteins; High density lipoprotein; Homologous Chemotactic Cytokines; Human; Human, General; Hydrogen Oxide; INFLM; In Vitro; Individual; Inflammation; Inflammatory; Intercrines; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; JUN Family Gene; JUN Proto-oncogene Family; JUN gene; Kinases; Knockout Mice; Lead; Leiomyocyte; Lesion; Ligands; Link; Lipids; Lipoproteins, HDL; Liver; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Murine; Mus; Myocardial Ischemia; Myocytes, Smooth Muscle; Nuclear Receptors; Null Mouse; Oncogens; Organ System, Cardiovascular; Oxygen Radicals; Pb element; Phenotype; Phosphorylation; Phosphotransferases; Pro-Oxidants; Process; Production; Property; Property, LOINC Axis 2; Protein Phosphorylation; Public Health; RNA Expression; RXR; RXR Protein; Reactive Oxygen Species; Receptor Protein; Receptor Signaling; Recruitment Activity; Retinoic Acid Receptor RXR; Retinoid X Receptors; Risk; Role; SIS cytokines; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Streaks, Arterial Fatty; Stress; Targetings, Gene; Toxic Environmental Agents; Toxic Environmental Substances; Toxic effect; Toxicities; Trans-Activation (Genetics); Transactivation; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transphosphorylases; Up-Regulation; Vascular, Heart; Water; alpha-Lipoproteins; atheromatosis; atherosclerosis plaque; atherosclerotic lesions; atherosclerotic plaque; atherosclerotic vascular disease; biological signal transduction; body system, hepatic; c jun; c-jun Gene; carcinogenesis; cardiovascular disorder; cell growth; cell type; chemoattractant cytokine; chemokine; cholesterol metabolism; circulatory system; design; designing; drinking water; environmental contaminant; environmental contamination; environmental toxicant; experiment; experimental research; experimental study; exposed human population; heart ischemia; heavy metal Pb; heavy metal lead; human exposure; in vivo; insight; interventional strategy; liver metabolism; macrophage; mouse model; myocardial ischemia/hypoxia; myocardium ischemia; organ system, hepatic; public health medicine (field); public health relevance; receptor; receptor expression; receptor function; recruit; research study; social role; vascular; vulnerable plaque",The role of LXR/RXR heterodimers in arsenic-induced atherosclerosis.," Project narrative Arsenic is a widespread environmental contaminant and listed as the number one health hazard by the EPA. Those individuals exposed to arsenic in the environment are at a greater risk for developing cardiovascular disease. Therefore, we propose experiments designed to understand how arsenic is linked to the development of atherosclerosis in the hope to identify potential interventions.",14911,ZRG1,Special Emphasis Panel,,2,136772,
7751243,R21,EY,5,,12/01/2009,11/30/2010,PA-06-181,5R21EY018370-02,,NEI:183769;,2010,NATIONAL EYE INSTITUTE,,MADISON,UNITED STATES,OPHTHALMOLOGY,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"KAUFMAN, PAUL LEON;",1880983;,5R21EY018370,12/01/2008,11/30/2010,"Affect; Age; Anterior; Artifacts; Autopsy; Biological; Body Tissues; Cell Nucleus; Chemicals; Ciliary Body; Ciliary Muscle; Ciliary Process; Ciliary muscle structure; Data; Devices; Dysfunction; Educational process of instructing; Elasticity; Exhibits; Eye; Eyeball; Fiber; Figs; Figs - dietary; Foundations; Functional disorder; Future; Goals; Human; Human, General; Image; Individual; Intervention; Intervention Strategies; Intraocular Pressure; Intraocular lens implant device; Laboratories; Lenses, Intraocular; Life; Macaca mulatta; Mammals, Primates; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Modality; Modeling; Monkeys; Morphologic artifacts; Movement; Muscle; Muscle Tissue; Nucleus; Ocular Tension; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Physiologic Intraocular Pressure; Physiopathology; Plant Leaves; Play; Position; Positioning Attribute; Posters; Posters [Publication Type]; Presbyopia; Presbyopias; Primates; Productivity; Relative; Relative (related person); Research; Rest; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; Sclerosis; Shapes; Solid; Structure; Structure of ciliary processes; Surface; Surgical; Surgical Interventions; Surgical Procedure; Teaching; Techniques; Therapeutic; Time; Tissues; Ultrasonic Biomicroscopy; Ultrasonic bio-microscopy; Ultrasonographic Biomicroscopy; Ultrasound Biomicroscopies; age dependent; age related; base; body movement; cost; experiment; experimental research; experimental study; imaging; in vivo; instrument; interventional strategy; leaf; lens; necropsy; next generation; non-human primate; nonhuman primate; pathophysiology; posters; postmortem; public health relevance; research study; social role; surgery; theories",Extra-lenticular aspects of accommodation and presbyopia," NARRATIVE Our goal is to determine what role the extralenticular tissues play in the pathophysiology of age- related ciliary muscle immobility in the non-human primate, and to determine whether the resulting model is relevant to human presbyopia. This may be crucial in enabling the function of next- generation intraocular lenses (IOLs).",18370,AED,Anterior Eye Disease Study Section,,2,183769,
7754384,R21,EY,5,,01/01/2010,12/31/2010,PAR-06-326,5R21EY019253-02,,NEI:253877;,2010,NATIONAL EYE INSTITUTE,,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"DAMMANN, OLAF ;",2315262;,5R21EY019253,01/01/2009,12/31/2010,"0-11 years old; 0-6 weeks old; 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-; 2-(Acetyloxy)benzoic Acid; Acetylsalicylic Acid; Admission; Admission activity; Analysis, Data; Aspergum; Aspirin; Bacteria; Bacteriology; Blindness; Blood; Body Tissues; CO2; Carbon Dioxide; Carbonic Anhydride; Causality; Characteristics; Child; Child Youth; Childhood; Children (0-21); Chorioamnionitis; Cities; Clinical; Cohort Studies; Concurrent Studies; Consent; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Duct; Duct (organ) structure; Dysfunction; Ecotrin; Embryonic Tissue, Placenta; Empirin; Enrollment; Entericin; Ethics Committees, Research; Etiology; Exposure to; Extren; Eye Exam; Eye Examination; Fetal Age; Fetal Maturity, Chronologic; Functional disorder; Funding; Gestation; Gestational Age; Goals; Histologic; Histologically; Histology; Human, Child; INFLM; IRBs; Impairment; Incidence; Individual; Indocin; Indometacin; Indomethacin; Infant; Infant, Newborn; Infant, Premature; Infection; Infection of amniotic sac and membranes; Inflammation; Inflammatory; Institution; Institutional Review Boards; Intervention; Intervention Strategies; Knowledge; Lead; Legal patent; Logistic Regressions; Low Birth Weight Infant; Measurin; Methods and Techniques; Methods, Other; Microbiology; Modeling; Mothers; NIH; National Eye Institute; National Institutes of Health; National Institutes of Health (U.S.); Neonatal; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Newborn Infant; Newborns; O element; O2 element; Ophthalmic examination and evaluation; Oxygen; Patents; Pathogenesis; Pb element; Physiopathology; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Pregnancy; Premature Infant; Process; R01 Mechanism; R01 Program; RPG; Reaction; Regressions, Logistic; Reporting; Research; Research Ethics Committees; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Reticuloendothelial System, Blood; Retinopathy of Prematurity; Retrolental Fibroplasia; Retrolental Fibroplasias; Risk; Risk Factors; Role; Science of Microbiology; Sight; Solid; Techniques; Testing; Tissues; United States National Institutes of Health; VLBW (human); Vision; Visual; Vitamin E; Woman; acronyms; blood product; children; clinical data repository; clinical data warehouse; data repository; design; designing; disability; disease causation; disease etiology; disease/disorder etiology; disorder etiology; enroll; heavy metal Pb; heavy metal lead; interventional strategy; low birth weight infant human; low birthweight; microorganism culture; nervous system disorder; neurological disease; newborn human (0-6 weeks); pathophysiology; pediatric; peer; preference; premature baby; premature infant human; premature retinopathy; preterm baby; preterm infant; preterm infant human; preterm neonate; relational database; social role; youngster",Placenta bacteriology and histology in the etiology of retinopathy of prematurity,,19253,ZEY1,Special Emphasis Panel,,2,253877,
7754375,R21,EY,5,,01/01/2010,12/31/2010,PA-08-044,5R21EY019383-02,,NEI:189956;,2010,NATIONAL EYE INSTITUTE,,WASHINGTON,UNITED STATES,BIOCHEMISTRY,00,049515844,US,DC,20057,GEORGETOWN UNIVERSITY,"GOLESTANEH, NADY ;",9198381;,5R21EY019383,01/01/2009,12/31/2010,"21+ years old; 4B4 Antigen; Adult; Age related macular degeneration; Anaplastic; Antibodies; Applications Grants; Autograft; Autologous; Autologous Transplantation; Autotransplant; Basement membrane; Biology; Biopsy; Blastocytes; Blastomeres; Blindness; Blood Vessels; Body Tissues; CD29 Antigen; CDw29 Antigen; Cell Lineage; Cell surface; Cells; Central Nervous System; Characteristics; Country; Culture Media; DNA Methylation; Degenerative Disorder; Disease; Disorder; Dysembryoma; ES cell; Electroretinography; Embryo; Embryonic; Embryonic Cell; Ensure; Ethical Issues; Ethics; Eye; Eyeball; Fibroblasts; Future; Gametes; Gene Expression; Genes; Genetic; Genetics, Karyotyping; Genital System, Male, Testis; Genomics; Germ Cells; Germ Layers; Germ Lines; Germ-Line Cells; Glaucoma; Goals; Gonadal structure; Gonads; Grant; Grant Proposals; Grants, Applications; Hand; Human; Human, Adult; Human, General; In Vitro; Infection; Injection of therapeutic agent; Injections; Integrin beta1; Investigators; Issues, Ethical; Karyotype; Karyotype determination procedure; Karyotyping; Laboratories; Literature; Maculopathy, Age-Related; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mice; Mice, Transgenic; Microscopic; Modification; Mother Cells; Murine; Mus; Natural regeneration; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, CNS; Neural Cell; Neural Retina; Neural Stem Cell; Neuraxis; Neurocyte; Neurons; Organ; P38 Membrane Protein, Synaptic Vesicle; Paper; Pattern; Photoreceptor Cell; Photoreceptors; Photoreceptors, Retinal; Photosensitive Cell; Pigmentary Retinopathy; Pilot Projects; Pluripotent Stem Cells; Population; Progenitor Cells; Proliferating; Protein P38, Synaptic Vesicle; Publications; Publishing; Receptor Protein; Regeneration; Reporting; Reproductive Cells; Research Personnel; Research Resources; Researchers; Resources; Retina; Retina Proper; Retinal; Retinal Degeneration; Retinal Photoreceptors; Retinitis Pigmentosa; Retroviridae; Retroviridae Infections; Retroviridae disease; Retrovirus Infections; Retroviruses; Rod-Cone Dystrophy; Rodent; Rodentia; Rodentias; Scientific Publication; Seminiferous Tubules; Seminiferous tubule structure; Sex Cell; Skin; Sorting - Cell Movement; Source; Spermatogonia; Spermatophores; Stem cells; Structure of blastomere; Synaptophysin; Tapetoretinal Degeneration; Telomerase; Teratoid Tumor; Teratoma; Testicles; Testing; Testis; Therapeutic; Therapeutic Agents; Therapeutic Uses; Time; Tissues; Transgenic Mice; Transgenic Model; Transplantation; Transplantation, Autologous; Tumorigenicity; Undifferentiated; United States; Vertebrate Animals; Vertebrates; Virus-Retrovirus; Visual Receptor; Work; adult human (21+); adult stem cell; base; blastomere structure; cell type; degenerative condition; degenerative disease; disease/disorder; electroretinogram; embryonic stem cell; experiment; experimental research; experimental study; glaucomatous; growth media; hESC; human ES cell; human ESC; human embryonic stem cell; in vivo; initial cell; karyogram; male; meetings; mouse model; nerve stem cell; nervous system transplantation; nestin; nestin protein; neural; neural progenitor cells; neurofilament; neuronal; neuronal progenitor; neuronal progenitor cells; novel; organ regeneration; pilot study; pluripotency; progenitor; prospective; public health relevance; receptor; regenerate; relating to nervous system; research study; retina degeneration; retinal degenerative; retinal neuron; retinal progenitor; retinal progenitor cell; retinal stem cell; senile macular disease; sexual cell; sorting; spermatogone; spermatospore; spermigonium; spermospore; stem; stem cell differentiation; stem cell of embryonic origin; transcription factor; transplant; tumorigenic; vascular; vertebrata",Pluripotent Adult Spermatogonial Stem Cells: Prospective for Retinal Degeneration," Project Narrative  Retinal degeneration is the leading cause of blindness in the United States and other first world countries characterized by loss of retinal photoreceptor cells. Recent reports show that retinal progenitor cells can be derived from mouse embryonic stem (ES) cells and may provide an alternative to adult derived retinal stem cells. However, the use of ES cells requires the destruction of the embryos and creates ethical issues and concerns. Recently, we have demonstrated that adult human spermatogonial stem cells (SSCs) can be reprogrammed to pluripotency spontaneously, using appropriate culture media, without genomic modification and retroviral infection. We have reprogrammed the SSCs to pluripotent stem cells capable of differentiating into all three germ layers. We have induced the differentiation of various cell lineages including neuronal precursors expressing neuronal specific markers, such as, nestin, neurofilament, synaptophysin and dopaminergic receptor 2 (Drd2).This approach is of paramount importance since human testicular biopsies may allow the cell-based, autologous organ therapy without the ethical and immunological problems associated with human embryonic stem cells, in the absence of genetic modification and retroviral infection. In this proposal we will examine the biology, the plasticity and therapeutic potential of human spermatogonial stem cells.",19383,ZRG1,Special Emphasis Panel,,2,189956,
7752508,R21,EY,5,,01/01/2010,12/31/2010,PA-06-181,5R21EY019401-03,,NEI:188100;,2010,NATIONAL EYE INSTITUTE,,DETROIT,UNITED STATES,ANATOMY/CELL BIOLOGY,13,001962224,US,MI,48202,WAYNE STATE UNIVERSITY,"THUMMEL, RYAN  (contact);VIHTELIC, THOMAS S;",1937045;8586635 (contact);,5R21EY019401,01/01/2009,12/31/2010,"Affect; Albinism; Animal Model; Animal Models and Related Studies; Behavioral; Birth; Blindness; Body Tissues; Brachydanio rerio; Cell Death; Cells; Ceroid; Complex; Danio rerio; Data; Defect; Development; Doctor of Philosophy; Embryo; Embryonic; Event; Exhibits; Eye; Eyeball; Flies; Frame Shift Mutation; Frameshift Mutation; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics, in situ Hybridization; Gut Epithelium; Hair; Hereditary; Hermanski-Pudlak Syndrome; Hermansky Pudlak syndrome; Hermansky-Pudlak Syndrome; In Situ Hybridization; In Vitro; Individual; Inherited; Maintenance; Maintenances; Mammals, Mice; Messenger RNA; Methods; Methods and Techniques; Methods, Other; Mice; Modeling; Molecular; Murine; Mus; Mutation; Optic tract structure; Outer pigmented layer of retina; Parturition; Pathogenesis; Pathology; Pattern; Persons; Ph.D.; PhD; Phenotype; Photoreceptor Cell; Photoreceptors; Photosensitive Cell; Pigment cell layer of retina; Pigmentation; Pigmentation physiologic function; Pigmented layer of retina; Platinum; Platinum Black; Principal Investigator; Programs (PT); Programs [Publication Type]; Protein Trafficking; Proteins; Pt element; RNA, Messenger; RT-PCR; RTPCR; Reading Frame Shift Mutation; Research; Retinal; Retinal Defect; Retinal Pigment Epithelium; Retinal pigment epithelial cells; Reverse Transcriptase Polymerase Chain Reaction; Role; Sight; Skin; Structure of retinal pigment epithelium; Study models; Techniques; Tissues; Tracts, Optic; Traffickings, Protein; VPS; Vacuolar Protein Sorting; Vision; Visual Acuity; Visual Receptor; Visual System; Visual system structure; Work; Zebra Danio; Zebra Fish; Zebrafish; experiment; experimental research; experimental study; fly; gastrointestinal epithelium; gene product; genome mutation; in situ Hybridization Staining Method; intervention development; knock-down; legally blind; mRNA; model organism; mutant; necrocytosis; novel; overexpression; prevent; preventing; programs; protein function; protein transport; public health relevance; research study; reverse transcriptase PCR; social role; therapy development; treatment development",The platinum zebrafish is a model for studying vision defects caused by albinism," Program Director/Principal Investigator (Last, First, Middle): Ryan Thummel, Ph.D. PROJECT NARRATIVE  All individuals affected with albinism exhibit vision problems and most are legally blind. However, the pathogenesis underlying photoreceptor loss in albinism is complex and poorly understood. We aim to establish the platinum zebrafish mutant as a model for studying the mechanisms underlying vision defects associated with albinism. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page",19401,ZRG1,Special Emphasis Panel,,3,188100,
7761662,R21,EY,5,,02/01/2010,01/31/2011,PA-06-181,5R21EY019406-02,,NEI:194288;,2010,NATIONAL EYE INSTITUTE,,CLEVELAND,UNITED STATES,BIOMEDICAL ENGINEERING,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"VON RECUM, HORST A.;",2053525;,5R21EY019406,02/01/2009,01/31/2011,"ANXA5; Address; Age related macular degeneration; Anchorin CII; Annexin A5 Protein; Annexin V; Anti-Sense Oligonucleotides; Antisense Agent; Antisense Oligonucleotides; Apoptosis; Apoptosis Pathway; Area; Assay; Bioassay; Biologic Assays; Biological; Biological Assay; Blotting, Western; Body Tissues; Bone-Derived Transforming Growth Factor; CBP-I; Calphobindin I; Cataract; Cataract Extraction; Cell Culture Techniques; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Survival; Cell Viability; Cell model; CellLine; Cells; Cellular model; Cicatrix; Clinic; Clinical; Code; Coding System; Compliance behavior; Cornea; DNA; DNA delivery; Data; Dendrimers; Dendritic Compounds; Dendrons; Deoxyribonucleic Acid; Diabetic Retinopathy; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Formulations; Drug Targeting; Drug Targetings; Drugs; Encapsulated; Endonexin II; Environment; Eye; Eye diseases; Eyeball; Familiarity; Fiber; Fibroblasts; Fluorescence; Fluorescence Microscopy; Formulation; Formulations, Drug; Future; GFP; Gene Expression; Gene Expression Inhibitor; Gene Inactivation; Gene Silencing; Glaucoma; Goals; Green Fluorescent Proteins; Half-Life; Half-Lifes; Human; Human, General; Implant; Investigation; Investigators; Kinetic; Kinetics; Laboratories; Lead; Lipocortin-V; Liposomal; Liposomes; Liquid substance; Macular degeneration; Macular degenerative disease; Maculopathy, Age-Related; Man (Taxonomy); Man, Modern; Medication; Micelles; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Milk Growth Factor; Modeling; Nucleic Acids; Oligo; Oligonucleotides; Oligonucleotides, Antisense; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; PAP-I; PP4; Patient Care; Patient Care Delivery; Patient Compliance; Patient Cooperation; Pb element; Peptides; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Placental Anticoagulant Protein I; Placental Protein 4; Platelet Transforming Growth Factor; Polymers; Predisposition; Pressure; Pressure- physical agent; Process; Proliferative Vitreoretinopathy; Public Health; RNA, Small Interfering; Research; Research Personnel; Researchers; Scars; Simulate; Small Interfering RNA; Solutions; Staining method; Stainings; Stains; Surface; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; System; System, LOINC Axis 4; TGF B; TGF-beta; TGFbeta; Testing; Therapeutic; Therapeutic Effect; Thromboplastin Inhibitor; Time; Tissues; Transfection; Transforming Growth Factor beta; Translations; Treatment Compliance; Up-Regulation; Up-Regulation (Physiology); Upregulation; VAC-Alpha; VEGFs; Vascular Anticoagulant-Alpha; Vascular Endothelial Growth Factors; Vegf; Vitreoretinopathy, Proliferative; Western Blotting; Western Blottings; Western Immunoblotting; Work; annexin A5; aptamer; aqueous; base; biodegradable polymer; bioresorbable polymer; cataract surgery; cataractogenesis; cataractous lenses; cicatrix corneal; compliance cooperation; controlled release; corneal; corneal scar; cost; cultured cell line; degradable polymer; disease/disorder; drug/agent; effective therapy; eye disorder; fluid; glaucoma surgery; glaucomatous; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; knock-down; liquid; nano fiber; nano meter scale; nano meter sized; nano scale; nano sized; nanofiber; nanofibrous; nanometer scale; nanometer sized; nanoscale; nanosized; new therapeutics; next generation therapeutics; novel; novel therapeutics; ophthalmopathy; overexpression; patient adherence; pressure; protein blotting; protein expression; public health medicine (field); public health relevance; scaffold; scaffolding; senile macular disease; siRNA; small molecule; success; surgery; therapy compliance; therapy cooperation; vector",DNA Delivery for Treatment of Proliferative Vitreoretinopathy and Ocular Scarring," Project Narrative  This proposal is critically concerned with the issue of public health in that its long term goal is to provide a drug delivery platform for providing sustained release of molecules to treat intraocular diseases. The short term goal is whether polymer nanofibers can deliver DNA to knock down expression of TGF-¨ in cell culture models of intraocular scarring disorders including corneal scarring, post-surgical scarring, and proliferative vitreoretinopathy.",19406,ZRG1,Special Emphasis Panel,,2,194288,
7751341,R21,HD,5,,01/01/2010,12/31/2010,PA-06-181,5R21HD054876-02,,NICHD:185625;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BALTIMORE,UNITED STATES,PEDIATRICS,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"VISCARDI, ROSE MARIE;",1925188;,5R21HD054876,01/01/2009,12/31/2010,"0-6 weeks old; ASPR; Adolescent; Adolescent Youth; Affect; Amniotic Fluid; Animal growth regulators, transforming growth factors; Animals; Aqua Amnii; Archives; Aspirate; Aspirate substance; Autopsy; BPD; Baboons; Bacteria; Barotrauma; Blood Neutrophil; Blood Plasma; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood monocyte; Bronchopulmonary Dysplasia; C3H/HeN Mouse; Cachectin; Cachectin-Tumor Necrosis Factor; Carbamide; Cell Communication and Signaling; Cell Signaling; Cells; Chronic; Chronic lung disease; Data; Detection; Development; Disease; Disorder; Distal; Dysbarism; Elaqua XX; Elastin; Embryonic Tissue, Placenta; Employee Strikes; Eperythrozoon; Epithelial; Event; Exhibits; Experimental Animal Model; Exposure to; Fibrosis; Future; Generations; Genital; Genital system; Gestation; Haemobartonella; Heterophil Granulocyte; Human; Human, General; Hyperoxia; IL-1; IL1; INFLM; Immune response; In Vitro; Infant; Infant, Newborn; Infant, Premature; Infection; Inflammation; Inflammatory; Inflammatory Response; Injury; Interleukin I; Interleukin-1; Interruption; Intracellular Communication and Signaling; Laboratories; Lead; Liquor Amnii; Lung; Lymphocyte-Stimulating Hormone; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Neutrophil; Marrow monocyte; Mechanical ventilation; Mice; Modeling; Morbidity; Morbidity - disease rate; Mouse Strains; Murine; Mus; Mycoplasma; Myofibroblast; Neonatal; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Newborn Infant; Newborns; O element; O2 element; OSM; Organism; Ovis; Oxygen; Papio; Papios; Pathogenesis; Pathogenicity; Pathologic; Pathology; Pb element; Phenotype; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Plasma; Pneumonia; Pneumonitis; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Population Study; Predisposition; Pregnancy; Premature Infant; Process; Pulmonary Body System; Pulmonary Inflammation; Pulmonary Organ System; Recombinant Oncostatin M; Research Specimen; Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; Reticuloendothelial System, Serum, Plasma; Risk Factors; Role; Savanna Baboons; Serum, Plasma; Sheep; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Staging; Stimulus; Strikes; Strikes, Employee; Susceptibility; T Helper Factor; T-Mycoplasma; TNF (unspecified); TNF Receptor Ligands; TNF-alpha; Testing; Tracts, Respiratory; Transforming Growth Factors; Tumor Growth Factors; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Urea; Urea Carbamide; Ureaphil; Ureaplasma; Ureaplasma Infections; Ureaplasma parvum; Ureaplasma urealyticum; Ureaplasma urealyticum biovar 1; Ureaplasma urealyticum biovar 2; Waters (Amniotic Fluid); biological signal transduction; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; cost; cytokine; disease/disorder; genetic manipulation; heavy metal Pb; heavy metal lead; host response; immunoresponse; in utero; infant chronic lung disease; interstitial; juvenile; juvenile human; living system; lung development; lung injury; lymphocyte activating factor; mechanical respiratory assist; model development; monocyte; mouse model; necropsy; neonatal chronic lung disease; neonatal lung injury; neutrophil; newborn chronic lung disease; newborn human (0-6 weeks); novel therapeutic intervention; oncostatin M; oxygen stress (breathing); postmortem; postnatal; premature baby; premature infant human; preterm baby; preterm infant; preterm infant human; preterm neonate; public health relevance; pulmonary; respiratory tract; response; social role; tumor necrosis factor (unspecified); ureaplasma infected; urogenital system (genital part)",Role of Intrauterine Ureaplasma-Infection in BPD Pathogenesis," PROJECT NARRATIVE: Babies who are born prematurely with a lung infection with the Ureaplasma bacteria may develop a chronic lung disease called bronchopulmonary dysplasia (BPD). To better understand this infection, this project will develop a mouse model to mimic the human infection.",54876,LIRR,"Lung Injury, Repair, and Remodeling Study Section",,2,185625,
7760645,R21,HD,5,,01/01/2010,12/31/2010,PA-06-181,5R21HD056316-02,,NICHD:194288;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CLEVELAND,UNITED STATES,ENGINEERING (ALL TYPES),11,135781701,US,OH,44195,CLEVELAND CLINIC LERNER COL/MED-CWRU,"ALBERTS, JAY L;",6071071;,5R21HD056316,01/16/2009,12/31/2010,"(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid; (--)-3-(3,4-Dihydroxyphenyl)-L-alanine; 3-Hydroxy-L-tyrosine; Abnormal Movements; Accounting; Address; Adverse effects; Aerobic; Affect; Agonist; American; Animals; Apoplexy; Area; Arm; Basal Ganglia; Basal Nuclei; Biomechanics; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Clinic; Clinical; Clinical Trial Overviews; Cognition; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Control Groups; Controlled Study; Coupling; Data; Data Pooling; Data Poolings; Deep Brain Stimulation; Development; Disease; Disorder; Disturbance in cognition; Drugs; Dyskinesias; Dyskinetic syndrome; Effectiveness; Evaluation; Exercise; Exercise Therapy; Exercise, Physical; Exhibits; Extremities; Functional Magnetic Resonance Imaging; Funding Mechanisms; Future; Goals; Grips; Guidelines; Home; Home environment; Human; Human, General; Idiopathic Parkinson Disease; Impaired cognition; Individual; Infection; Inpatients; Intervention; Intervention Strategies; L-3,4-Dihydroxyphenylalanine; L-Dopa; Lead; Levodopa; Lewy Body Parkinson Disease; Limb structure; Limbs; Lower Extremity; Lower Limb; MRI, Functional; Magnetic Resonance Imaging, Functional; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medical; Medication; Membrum inferius; Membrum superius; Meta-Analyses; Meta-Analysis; Modality; Modeling; Motor; Movement; Nerve Cells; Nerve Unit; Nervous System Diseases; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Nodal; Non-Trunk; Occupational Therapy; Operation; Operative Procedures; Operative Surgical Procedures; Out-patients; Outcome; Outpatients; Output; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Parkinsons disease; Patients; Pattern; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical therapy exercises; Primary Parkinsonism; Process; Production; QOL; Quality of life; Randomized; Risk; Rodent; Rodentia; Rodentias; Societies; Stimulus; Stroke; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; System; System, LOINC Axis 4; Therapeutic; Time; Training; Translating; Translatings; Treatment Cost; Treatment Side Effects; Triceps; Triceps Muscle; Triceps brachii muscle structure; Upper Extremity; Upper Limb; Upper arm; Vascular Accident, Brain; base; beta-(3,4-Dihydroxyphenyl)-L-alanine; body movement; brain attack; cerebral vascular accident; cognitive dysfunction; cognitive loss; cognitively impaired; cost; design; designing; disease/disorder; drug/agent; fMRI; grasp; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interventional strategy; language translation; motor control; nervous system disorder; neurological disease; neuromuscular; neuronal; non-drug; novel; primary outcome; prospective; public health relevance; randomisation; randomization; randomly assigned; side effect; stroke; surgery; therapy adverse effect; treatment adverse effect",Effects of forced exercise training on Parkinson's motor function," Project Narrative The clinical relevancy of this study is important as it addresses the effectiveness of a novel and innovative exercise intervention for the treatment of Parkinson's disease. Preliminary data will be gathered to assess the efficacy of using forced-exercise in the treatment of Parkinson's disease. The proposed forced-exercise intervention augments the voluntary movements of Parkinson's patients to assist them in achieving a greater rate of exercise. Animal studies suggest exercising at higher rates improves motor performance and has neuroprotective qualities. Comparisons in motor function will be made between patients completing eight weeks of forced, voluntary or no-exercise. It is predicted that forced-exercise will result in greater improvements in motor function than voluntary or no-exercise. The proposed force-exercise intervention is safe and inexpensive. With minimal space and costs the intervention could be replicated in large and small physical and occupational therapy clinics and in the home of the patient. This intervention will potentially lead to better treatment of Parkinson's disease and improve the quality of life of those suffering from Parkinson's. Society will benefit from this project as individuals suffering from other neurological disorders or stroke could also be positively impacted by these results.",56316,MRS,Musculoskeletal Rehabilitation Sciences Study Section,,2,194288,
7754881,R21,HD,5,,01/01/2010,12/31/2010,PA-06-181,5R21HD057684-02,,NICHD:145075;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,MADISON,UNITED STATES,VETERINARY SCIENCES,02,161202122,US,WI,537151218,UNIVERSITY OF WISCONSIN MADISON,"ZIEGLER, TONI ELAINE;",1993236;,5R21HD057684,01/05/2009,12/31/2010,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 21+ years old; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Adenohypophysis; Adult; Androst-4-en-17beta-ol-3-one; Anterior; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Antidiuretic Hormone; Antidiuretic Hormones; Aquadiol; Bears; Behavior; Behavioral; Birth; Brain; Callithrix; Callithrix jacchus; Callithrix jacchus jacchus; Caring; Child Development; Communication; Cues; Delta4-androsten-17beta-ol-3-one; Development; Dimenformon; Diogyn; Diogynets; Disease; Disorder; Dopamine; Dose; Encephalon; Encephalons; Estra-1,3,5(10)-triene-3,17-diol (17beta)-; Estrace; Estradiol; Estradiol-17 beta; Estradiol-17beta; Estraldine; Event; Exhibits; Fathers; Female; Foundations; Gestation; Hapale; Health; Hormonal; Hormonal Change; Human; Human, Adult; Human, General; Hydroxytyramine; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; In Vitro; Infant; Infant Care; Infant and Child Development; LTH; Lactogenic Hormone, Pituitary; Mammalia; Mammals; Mammals, General; Mammals, Primates; Mammals, Rodents; Mammotropic Hormone, Pituitary; Mammotropin; Man (Taxonomy); Man, Modern; Marmoset, Common; Marmoset, Short-Tusked; Marmosets; Maternal Behavior; Monitor; Nervous; Nervous System, Brain; Nervous System, Pituitary; Neuroendocrine; Neuroendocrine System; Neurohypophysis; Neurosecretory Systems; OXT; Ocytocin; Outcome; Ovis; Ovocyclin; Ovocylin; Oxytocin; PRL; PRL (Prolactin); Parenting; Parenting behavior; Pars Anterior Pituitary Gland; Partner in relationship; Parturition; Paternal Behavior; Pathway interactions; Peptides; Peripheral; Pituitary; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Pituitary Hormones; Posterior Lobe of the Pituitary Gland; Posterior Pituitary Gland; Pregnancy; Primates; Production; Progynon; Prolactin; Recombinant Oxytocin; Rodent; Rodentia; Rodentias; Role; Sampling; Sheep; Steroid Compound; Steroids; Stimulus; Study models; Testing; Testosterone; Therapeutic Estradiol; Therapeutic Steroid Hormone; Therapeutic Testosterone; Trans-Testosterone; Ursidae; Ursidae Family; Vasopressins; abuse neglect; adult human (21+); beta-Hypophamine; disease/disorder; experience; experiment; experimental research; experimental study; family structure; hypothalamic; in vitro testing; in vivo; infant health care; intervention development; luteotropic hormone; luteotropin; male; mate; method development; neglect and abuse; neural; novel; offspring; pathway; posterior lobe of pituitary; posterior pituitary; psychosocial; public health relevance; relating to nervous system; reproductive; research study; response; social organization; social role; steroid hormone; therapy development; treatment development",Neuroendocrine Control of Paternal Care in the Common Marmoset," Project Narrative This project seeks to understand the factors underlying quality paternal care in males. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Fathers can contribute significantly to the positive outcome of infant and child development.",57684,BRLE,"Biobehavioral Regulation, Learning and Ethology Study Section",,2,145075,
7755042,R21,HD,5,,01/01/2010,12/31/2010,PAR-06-342,5R21HD059823-02,,NICHD:259875;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"GRABOWSKI, GREGORY A.;",1897200;,5R21HD059823,01/10/2009,12/31/2010,"0-6 weeks old; Acids; Address; Affect; Bears; Biochemical; Brain; CNS Diseases; CNS disorder; Central Nervous System Diseases; Central Nervous System Disorders; Ceramide glucosyltransferase; Cerebroside Lipidosis Syndrome; Chaperone; Chemicals; Defect; Disease; Disease Progression; Disease model; Disorder; Encephalon; Encephalons; Engineering; Engineerings; Exhibits; Future; Gaucher Disease; Gaucher Disease, Neuronopathic; Gauchers Disease; GlcCer synthase; GlcSph; Glucocerebrosidase Deficiency Disease; Glucocerebrosides; Glucosyl Ceramides; Glucosylceramide Beta-Glucosidase Deficiency Disease; Glucosylceramides; Hereditary Metabolic Disorder; Human; Human, General; Inborn Errors of Metabolism; Infant, Newborn; Intermediary Metabolism; Intervention; Intervention Strategies; Investigators; Lead; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Medical; Metabolic Processes; Metabolism; Metabolism, Inborn Errors; Mice; Molecular Chaperones; Murine; Mus; Mutate; Nervous System, Brain; Neuronopathic Gaucher Disease; Newborn Infant; Newborns; Outcome; Pathogenesis; Pathologic Processes; Pathological Processes; Pb element; Phenotype; Research; Research Personnel; Researchers; Residual; Residual state; Screening procedure; Testing; Therapeutic; Time; UDP-glucose-N-acylsphingosine glucosyltransferase; UDP-glucose-ceramide glucosyltransferase; UDPglucose-ceramide glucosyltransferase; Ursidae; Ursidae Family; Variant; Variation; ceramide UDPG glucosyltransferase; cerebroside synthase; disease/disorder; disorder model; early onset; familial splenic anemia; glucocerebroside synthetase; glucocerebrosidosis; glucosidase; glucosylceramidase deficiency; glucosylceramide lipidosis; glucosylceramide synthase; glucosylsphingosine; glycosylceramide synthetase; heavy metal Pb; heavy metal lead; in vivo; inborn lysosomal enzyme disorder; inborn metabolism disorder; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; interventional strategy; lipoid histiocytosis (kerasin type); mouse model; newborn human (0-6 weeks); novel; pre-clinical therapy; preclinical therapy; prevent; preventing; prototype; public health relevance; response; screening; screenings; trafficking",Therapy of Neuronopathic Gaucher Disease, RESEARCH & RELATED Other Project Information 7. Project Narrative: These studies endeavor to address the unmet medical need of treatment for early onset diseases that effect the brain and lead to degeneration. The proposed studies will investigate the use of new chemical treatments for model diseases in specifically engineered mice. The outcomes have implications for the lysosomal storage diseases and related inborn errors of metabolism.,59823,ZHD1,Special Emphasis Panel,,2,259875,
7756590,R21,HD,5,,01/01/2010,12/31/2010,PA-06-181,5R21HD060169-02,,NICHD:201353;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,BALTIMORE,UNITED STATES,PHYSICAL MEDICINE & REHAB,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"CELNIK, PABLO ARIEL;",8496116;,5R21HD060169,01/15/2009,12/31/2010,"Abnormal gait; Address; Apoplexy; Behavior; Behavior assessment; Behavioral; Brain; Brain Part; Central Nervous System; Cerebellum; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cerebrum; Coupling; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Encephalon; Encephalons; Ensure; Environment; Gait; Gait abnormality; Gait disorder; Gait disturbances; Goals; Hand; Impairment; Individual; Intervention; Intervention Strategies; Investigation; Knowledge; Laboratories; Learning; Leg; Lesion; Life; Locomotion; Locomotor adaptation; Methods; Motion; Motor; Movement; Nervous; Nervous System, Brain; Nervous System, CNS; Neuraxis; Neurologic; Neurological; Painless; Pathway interactions; Patients; Pattern; Performance; Physical Health Services / Rehabilitation; Physiologic; Physiological; Physiology; Process; Public Health; Recovery; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; Research; Simulate; Sound; Sound - physical agent; Specificity; Speed; Speed (motion); Stroke; Structure; Survivors; Technology; Testing; Therapeutic Intervention; Training; Transcranial magnetic stimulation; Vascular Accident, Brain; Walking; Work; behavioral assessment; body movement; brain attack; cerebral vascular accident; design; designing; experiment; experimental research; experimental study; flexibility; improved; interest; intervention therapy; interventional strategy; locomotor learning; locomotor tasks; motor learning; neural; novel; novel therapeutic intervention; pathway; public health medicine (field); public health relevance; rehabilitative; relating to nervous system; research study; sound; stroke; theories; visual memory",Non-invasive Cerebellar Stimulation to Improve Locomotion," R21 Project Narrative This proposal will investigate the behavioral and physiological effects of applying transcranial direct current stimulation (tDCS), a form of non-invasive non-painful stimulation, to the cerebellum. The goal is to enhance cerebellar function, which would result in an improvement in locomotor learning. We will test this intervention in healthy individuals and stroke patients with gait impairment. If successful, tDCS could become an easy and inexpensive therapeutic intervention to enhance locomotor training in stroke patients and other neurological conditions.",60169,MRS,Musculoskeletal Rehabilitation Sciences Study Section,,2,201353,
7755804,R21,HL,5,,01/01/2010,12/31/2010,PA-08-084,5R21HL088625-02,,NHLBI:217500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"HALANYCH, JEWELL H;",7911329;,5R21HL088625,01/15/2009,12/31/2010,"Accounting; Affect; African American; Afro American; Afroamerican; American; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Area; BP control; Behavioral; Black Populations; Black or African American; Blood Pressure; Blood Pressure, High; Cardiovascular Diseases; Care, Health; Caring; Cognitive; Cognitive Discrimination; Communication; Delivery of Health Care; Development; Discrimination; Discrimination (Psychology); Drugs; Environment; Environmental Factor; Environmental Risk Factor; Ethics; Ethnic and Racial Minorities; European; Focus Groups; Goals; Health; Health Psychology; Health Sciences, Allied and Health Services Delivery; Healthcare; Healthcare Delivery; Healthcare Systems; High Prevalence; Human; Human, General; Hypertension; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Individual; Intervention; Intervention Strategies; Investigators; Knowledge; Left; Life; Linguistic; Linguistics; Man (Taxonomy); Man, Modern; Measurement; Measures; Medical; Medication; Minority Groups; Models, Theoretic; Nature; PROV; Patients; Perception; Personal Behavior; Personal Conduct; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physicians; Play; Position; Positioning Attribute; Primary Care; Primary Health Care; Primary Healthcare; Process; Property; Property, LOINC Axis 2; Provider; Psychology, Health; Psychometric; Psychometrics; Public Health; Publishing; Qualitative Research; Reporting; Research; Research Personnel; Researchers; Role; Sampling; Sound; Sound - physical agent; Stress; Systems, Health Care; Testing; Theoretical model; Treatment Efficacy; Trust; Validity and Reliability; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Visit; Work; allostatic load; base; black American; blood pressure control; blood pressure homeostasis; blood pressure regulation; cardiovascular disorder; drug/agent; efficacy testing; environmental risk; ethnic discrimination; experience; health care delivery; hyperpiesia; hyperpiesis; hypertensive disease; instrument; interest; interventional strategy; multidisciplinary; primary care setting; public health medicine (field); public health relevance; racial and ethnic; racial/ethnic; response; social; social cognitive theory; social role; sound; theories; therapeutic efficacy; therapeutically effective; tool",Perceived Discrimination in Medical Care," The perception that patients are being discriminated against while receiving health care may be an important contributor to health care disparities. This project will develop an instrument to measure what personal, behavioral, and environmental factors contribute to perceived discrimination in primary care. This instrument will allow the investigators to test the efficacy of interventions focusing on reduction/elimination of perceived discrimination in primary care settings.",88625,CIHB,Community Influences on Health Behavior,,2,217500,
7751330,R21,HL,5,,12/01/2009,11/30/2010,PA-06-181,5R21HL093531-03,,NHLBI:184971;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HERSHEY,UNITED STATES,PHYSIOLOGY,17,129348186,US,PA,170330850,PENNSYLVANIA STATE UNIV HERSHEY MED CTR,"YENGO, CHRISTOPHER M;",6589116;,5R21HL093531,12/15/2008,11/30/2010,"ATP Hydrolysis; ATP phosphohydrolase; ATPase; ATPase, Actin-Activated; ATPase, Actomyosin; Actin Filaments; Actins; Active Sites; Actomyosin; Actomyosin Adenosinetriphosphatase; Adenosine Triphosphatase; Adenosine Triphosphatase, Myosin; Adenosinetriphosphatase; Adenosinetriphosphatase, Actomyosin; Adopted; Affinity; Algorithms; Arm; Asymmetric Septal Hypertrophy, Familial; Binding; Binding (Molecular Function); Biochemical; Biological Function; Biological Process; Biophysics; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cardiomyopathy, Hypertrophic, Familial; Cell division; Chemicals; Cleaved cell; Communication; Computing Methodologies; Coupled; Coupling; DNA Sequence Rearrangement; Data; Disease; Disorder; Dissociation; Doctor of Philosophy; FRET; Fluorescence; Fluorescence Resonance Energy Transfer; Fluorescent Probes; Future; Generations; Genetic Condition; Genetic Diseases; Goals; Hereditary Disease; Intracellular Transport; Kinetic; Kinetics; L-Tryptophan; Lead; Levotryptophan; Measures; Mechanics; Mediating; Methods; Methods and Techniques; Methods, Other; Microfilaments; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Disease; Molecular Dynamics Simulation; Molecular Interaction; Molecular Stereochemistry; Monitor; Monte Carlo Method; Motion; Motor; Movement; Muscle; Muscle Cell Contraction; Muscle Contraction; Muscle Tissue; Muscular Contraction; Myofilaments; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosin II; Myosin Pathway; Myosin Phosphatase Pathway; Myosin Type II; Myosin Type V; Myosin V; Myosins; Nucleotides; PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase; Pathway interactions; Pb element; Ph.D.; PhD; Phosphates; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Point Mutation; Probes, Fluorescent; Process; Production; Property; Property, LOINC Axis 2; Proteins; Rearrangement; Role; Side; Simulate; Sites, Active; Staging; Structure; System; System, LOINC Axis 4; Techniques; Testing; Tryptophan; Upper arm; V-ATPase; V-type ATPase; Ventricular Hypertrophy, Familial; Work; base; body movement; cleaved; computational methodology; computational methods; computer methods; conformation; conformational state; design; designing; disease/disorder; experiment; experimental research; experimental study; flexibility; gene product; genetic disorder; heavy metal Pb; heavy metal lead; hereditary disorder; improved; inorganic phosphate; insight; literature survey; models and simulation; molecular dynamics; myosin ATP phosphohydrolase (actin translocating); pathway; public health relevance; research study; simulation; social role; tool; vacuolar ATPase; vacuolar H+-ATPase; vacuolar membrane H(+)-ATPase",Energy Transduction in Myosin," Energy Transduction in Myosin  Project Narrative  Christopher M. Yengo, Ph.D.  The goal of this project is to determine how myosin converts chemical energy into force and motion to drive the process of muscle contraction. A combination of experimental and computational biophysical tools will be utilized to define the structural pathway of the actomyosin V ATPase cycle, which will fill in critical gaps in what is known about how myosin generates force in muscle contraction. Since point mutations in myosin are associated with genetic diseases such as Familial Hypertrophic Cardiomyopathy, elucidating the structural pathway for energy transduction in myosin may improve our understanding of and lead to future treatments for these diseases",93531,MSFC,Macromolecular Structure and Function C Study Section,,3,184971,
7755353,R21,HL,5,,01/01/2010,12/31/2010,PA-06-181,5R21HL094902-02,,NHLBI:188750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"NG, JASON ;",8676045;,5R21HL094902,01/15/2009,12/31/2010,"3D modeling; Arrhythmia; Asystole; Body Tissues; Cardiac; Cardiac Arrest; Cardiac Arrhythmia; Cardiac ablation; Cardiac infarction; Catheter Ablation; Catheters; Cause of Death; Cells; Cessation of life; Characteristics; Cicatrix; Computer Programs and Programming; Computer Simulation; Computer Software Tools; Computer Work stations; Computer Workstations; Computerized Models; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Data; Data Sources; Death; Death, Sudden; Death, Sudden, Cardiac; Defibrillators; Development; Devices; Electric Shock Cardiac Stimulators; Electrophysiology; Electrophysiology (science); Evaluation; Event; External Defibrillator; Goals; HOSP; Heart; Heart Arrest; Heart Arrhythmias; Hospitals; Image; Implant; Infarction; Left Ventricles; Left ventricular structure; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Morphology; Mortality; Mortality Vital Statistics; Muscle, Cardiac; Muscle, Heart; Myocardial Infarct; Myocardial Infarction; Myocardium; NMR Imaging; NMR Tomography; Neurophysiology / Electrophysiology; Nuclear Magnetic Resonance Imaging; Patients; Physiologic; Physiological; Predisposition; Prevention; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Reading; Resuscitation; Risk; Scars; Science; Sensitivity and Specificity; Simulate; Simulation, Computer based; Site; Software Tools; Sources, Data; Staging; Stimulators, Electrical, Cardiac, Shock; Stratification; Sudden Death; Susceptibility; System; System, LOINC Axis 4; Tachyarrhythmias; Tachycardia, Ventricular; Techniques; Testing; Tissue Viability; Tissues; Tools, Software; Training; United States; Ventricular; Ventricular Arrhythmia; Ventricular Fibrillation; Ventricular Tachycardia; Viability, Tissue; Zeugmatography; base; cardiac electrical activity; cardiac infarct; cardiac muscle; clinical applicability; clinical application; cohort; computational modeling; computational models; computational simulation; computer based models; computer program; computer programming; computerized modeling; computerized simulation; coronary attack; coronary infarct; coronary infarction; experience; healthy volunteer; heart attack; heart electrical activity; heart infarct; heart infarction; heart muscle; high risk; imaging; improved; in silico; infarct; novel; prevent; preventing; programs; public health relevance; tachyrhythmia; three-dimensional modeling; tool; user-friendly; virtual; virtual simulation",Virtual cardiac electrophysiologic testing for sudden death risk stratification," RELEVANCE Effective risk stratification for sudden cardiac death is necessary for timely and appropriate therapy. A non- invasive approach to detect whether a patient has the necessary substrate for arrhythmias could significantly improve the prevention of sudden cardiac death, a leading cause of mortality in the United States.",94902,ZRG1,Special Emphasis Panel,,2,188750,
7827962,R21,MH,5,,02/01/2010,01/31/2011,PAR-06-355,5R21MH082133-02,,NIMH:232055;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PSYCHIATRY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"GOLLAN, JACQUELINE K;",6438962;,5R21MH082133,05/08/2009,01/31/2011,"21+ years old; Active Follow-up; Adult; Affect; Affective; Affective Disorders; After Care; After-Treatment; Aftercare; Anterior; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Sciences; Behavioral Therapy; Behavioral Treatment; Blinking; Brain; Clinical; Clinical Sciences; Collaborations; Conditioning Therapy; Control Groups; Data; Depressed mood; Depression; Discipline; EEG; EMG; Early treatment; Electric Conductivity; Electrical Conductivity; Electrodermal Response; Electroencephalography; Electromyography; Emotional; Emotional Depression; Emotions; Encephalon; Encephalons; Evaluation; Event; Exhibits; Face; Fostering; GSR; Galvanic Skin Response; Goals; Human, Adult; Individual; Individual Differences; International; Interview; Investigation; Investigators; Laboratories; Left; Life Style Modification; Link; Major Depressive Disorder; Measurement; Measures; Mental Depression; Methods; Modeling; Mood Disorders; Muscle; Muscle Tissue; Nervous; Nervous System, Brain; Neurosciences Research; Outcome; Participant; Pathway interactions; Patient Self-Report; Patients; Pattern; Physiologic; Physiological; Process; Psychology, Physiologic; Psychology, Physiological; Psychophysiological; Psychophysiology; Psychotherapy; Reflex, Psychogalvanic; Relapse; Relative; Relative (related person); Reporting; Research; Research Activity; Research Personnel; Researchers; Residual; Residual state; Rest; Risk; Sampling; Scalp; Scalp structure; Science; Self-Report; Site; Skin; Skin Electric Conductance; Staging; Stimulus; Surface; Symptoms; Symptoms of depression; System; System, LOINC Axis 4; Testing; Time; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Translations; Treatment outcome; Work; adult human (21+); affective neuroscience; behavior intervention; behavioral intervention; biomarker; density; depressed; depressive; depressive symptoms; design; designing; electrical conductance; emotional stimulus; encephalography; eye blink; eyeblink; facial; follow-up; heuristics; indexing; information processing; instrument; intervention design; language translation; major depression; neural; neural circuit; neural circuitry; pathway; prognostic; prospective; psycho-physiological; psychologic; psychological; public health relevance; relating to nervous system; response; sadness; theories; therapy design; trait; translation research enterprise; translational approach; treatment design; treatment response",Translating Affective Science to Predict Outcomes of Behavioral Treatment for MDD," Project Narrative Consistent with the directive of PAR-06-355, ""Building Translational Research in Integrative Behavioral Science (R21)"", we will test an approach that integrates the discoveries and experimental methods from the disciplines of affective neuroscience, psychophysiology, and clinical science. Using a prospective treatment outcome design, we aim to test the degree to which physiological and affective processes, linked with activation of neural circuitry, predict clinical outcome and are readily identifiable in the early stages of behavioral treatment of major depression.",82133,ZMH1,Special Emphasis Panel,,2,232055,
7790532,R21,MH,5,,01/15/2010,12/31/2010,PA-06-377,5R21MH082925-02,,NIMH:192500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BLOOMINGTON,UNITED STATES,OBSTETRICS & GYNECOLOGY,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"RUPP, HEATHER ;",9116625;,5R21MH082925,03/21/2009,12/31/2010,"Address; Affective; Affective Disorders; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Model; Animal Models and Related Studies; Anterior; Area; Arousal; Behavioral; Birth; Brain; Brain imaging; Brain region; Breast Feeding; Breastfeeding; Buffers; Caring; Causality; Characteristics; Depressed mood; Depression; Depression, Postpartum; Development; Emotional; Encephalon; Encephalons; Environment; Equilibrium; Etiology; Exhibits; Family; Female; Functional Magnetic Resonance Imaging; Human; Human, General; Infant; Intervention; Intervention Strategies; Left; Life; Limbic System; Literature; MR Imaging; MR Tomography; MRI; MRI, Functional; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Maternal Behavior; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Mental Depression; Mental Health; Mental Hygiene; Mood Disorders; Moods; Mothers; NMR Imaging; NMR Tomography; Nasal; Nervous; Nervous System, Brain; Neural Inhibition; Neuranatomies; Neuranatomy; Neuroanatomies; Neuroanatomy; Neuroendocrinology; Neuropeptides; Nose; Nose, Nasal Passages; Nuclear Magnetic Resonance Imaging; OXT; Ocytocin; Oxytocin; PBO; Parents; Parturition; Pattern; Physiologic; Physiological; Placebos; Play; Post-Natal Depression; Post-Partum Depression; Postnatal Depression; Postpartum; Postpartum Depression; Postpartum Period; Postpartum Women; Prefrontal Cortex; Psychological Health; Recombinant Oxytocin; Respiratory System, Nose, Nasal Passages; Role; SUBGP; Sampling; Sham Treatment; Stimulus; Stress; Subgroup; System; System, LOINC Axis 4; Testing; United States; Woman; Women, Postpartum; Work; Zeugmatography; amygdaloid nuclear complex; balance; balance function; biological adaptation to stress; brain visualization; cingulate cortex; depressed; disease causation; disease etiology; disease/disorder etiology; disorder etiology; emotional stimulus; experience; fMRI; interventional strategy; model organism; motherhood; neural; neural patterning; neuroimaging; psychosocial; public health relevance; reaction; crisis; relating to nervous system; response; sadness; sham therapy; social role; stress response; stress; reaction; vigilance",Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging,"  PROJECT NARRATIVE  The extreme psychosocial and physiological changes inherent to motherhood leave many women vulnerable to mood disorders during the year following the birth of an infant. Maternal mood disorders have negative consequences not only for the mother experiencing the depression, but also for her infant, partner, and family. An understanding of the functional neuroendocrinological changes that occur with motherhood, such as oxytocin-mediated inhibition of neural activity related to negative emotional arousal, is critical to promote optimal maternal care and protection from mood disorders during the postpartum period.",82925,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,192500,
7799933,R21,MH,5,,02/01/2010,01/31/2011,PA-06-181,5R21MH083225-02,,NIMH:201250;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,08,079532263,US,MA,021111526,TUFTS MEDICAL CENTER,"OXENKRUG, GREGORY ;",8555141;,5R21MH083225,04/03/2009,01/31/2011,"3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-Hydroxytryptamine; 5HT; ALS; Adverse effects; Affect; Age; Alferon; Alleles; Allelomorphs; Amyotrophic Lateral Sclerosis; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Anxiety; Benzenebutanoic acid, alpha,2-diamino-gamma-oxo-; Cachectin; Cachectin-Tumor Necrosis Factor; Cancers; Cytokine Gene; Data; Depression; Dioxygenases; Enteramine; Enzymes; Female; Fertilized Egg; Fertilized Ovums; Frequencies (time pattern); Frequency; G-interferon; Gamma interferon; Gehrig's Disease; Gender; Genes; Genetic; Genetic Polymorphism; Genotype; Ginterferon; HCV infection; Hepatitis C; Hepatitis C Therapy; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hippophaine; Homo; IFN Alpha; IFN-Gamma; IFN-g; IFNG; IFNa; Individual; Inflammatory; Interferon Alfa-n3; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon-alpha; Interferon-gamma; Kynurenine; Literature; Lou Gehrig Disease; MS (Multiple Sclerosis); Malignant Neoplasms; Malignant Tumor; Mental Depression; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Multiple Sclerosis; NANBH; Ovum, Fertilized; PBMC; PT-NANBH; Parenterally-Transmitted Non-A, Non-B Hepatitis; Patients; Peripheral Blood Mononuclear Cell; Polymorphism (Genetics); Polymorphism, Genetic; Production; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Psychiatric therapeutic procedure; Psychoses; Psychotic Disorders; Regulation; Retrospective Studies; Risk; Sclerosis, Disseminated; Serotonin; Shunt; Shunt Device; Structure of zygote; TNF; TNF Alpha; TNF protein, human; TNF superfamily, member 2 protein, human; TNF-2 protein, human; TNF-alpha; TNFA; TNFSF2 protein, human; Treatment Side Effects; Tryptophan Metabolism; Tryptophan Metabolism Pathway; Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha (macrophage-derived); Up-Regulation; Up-Regulation (Physiology); Upregulation; Work; Zygote; cytokine; hepatitis non A non B; hepatitis nonA nonB; high risk; human TNF protein; indoleamine; insular sclerosis; lFN-Gamma; malignancy; neoplasm/cancer; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; polymorphism; psychiatric care; psychiatric therapy; psychiatric treatment; public health relevance; response; shunts; side effect; therapy adverse effect; treatment adverse effect; tumor necrosis factor, human; tumor necrosis factor-2 protein, human; tumor necrosis factor-alpha promoter allele-2 protein, human; zygote","Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications o", The proposed study aims to investigate whether analysis of cytokine gene polymorphisms might help to identify hepatitis C patients with high risk of developing psychiatric complications in response to IFN-alpha therapy,83225,NPAS,"Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section",,2,201250,
7769453,R21,MH,5,,01/28/2010,12/31/2010,PA-06-181,5R21MH083902-02,,NIMH:231750;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,PSYCHOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"SERENCES, JOHN ;",9243124;,5R21MH083902,02/12/2009,12/31/2010,"Affect; Afferent Neurons; Anal; Anus; Applied Research; Applied Science; Attention; Attention Deficit Disorder; Automobile Driving; Awareness; Awarenesses; Behavior; Behavioral; Brain; Categories; Characteristics; Code; Coding System; Cognition; Collection; Color; Complex; Computer Simulation; Computerized Models; Conscious; Consciousness; Data; Decision Making; Development; Diagnosis; Diagnostic tests; Disease; Disorder; Drivings, Automobile; Encephalon; Encephalons; Ensure; Environment; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Human; Human, General; Image Analyses; Image Analysis; Information Processing, Human; Information Theory; Intervention; Intervention Strategies; Intuition; Investigators; Knowledge; Lead; Light; Link; Location; MRI, Functional; Magnetic Resonance Imaging, Functional; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Processes; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Motor; Nature; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Noise; Output; Participant; Pattern; Pb element; Perception; Perceptual learning; Photoradiation; Physiologic pulse; Population; Process; Property; Property, LOINC Axis 2; Psychology, Physiologic; Psychology, Physiological; Psychophysic; Psychophysics; Psychophysiological; Psychophysiology; Pulse; ROC Analysis; Research Personnel; Research Proposals; Researchers; Scheme; Science of neurophysiology; Selective inattention; Sensory; Sensory Cell Afferent Neuron; Shapes; Short-Term Memory; Simulation, Computer based; Sorting - Cell Movement; Specific qualifier value; Specified; Stimulus; Task Performances; Techniques; Test Result; Testing; Theoretical Studies; Visual; Visual Cortex; Visual System; Visual system structure; Work; analytical method; base; cognitive neuroscience; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; directed attention; directs attention; disease/disorder; driving; experiment; experimental research; experimental study; extrastriate visual cortex; fMRI; heavy metal Pb; heavy metal lead; image evaluation; imaging modality; improved; in silico; information processing; interdisciplinary approach; interest; interventional strategy; neural; neural mechanism; neural patterning; neuroimaging; neuromechanism; neuronal; neurophysiology; new approaches; non-human primate; nonhuman primate; novel; novel approaches; novel strategies; novel strategy; preference; psycho-physiological; public health relevance; relating to nervous system; research study; response; selective attention; sensory cortex; sorting; success; teacher; tool; virtual simulation; visual cortical; visual search; working memory",Assessing space and feature based attention with fMRI and multivoxel pattern anal," Project Narrative Whether listening to a teacher in a classroom or driving a car down the road, the ability to pay attention to important parts of the environment is critical to our success and survival. In the present research proposal, we seek to understand how patterns of neural activity in the brain support attentive behavior so that an observer may more efficiently understand and represent incoming sensory information. This knowledge will aid in the development of more objective tests for common disorders of attention - such as attention deficit disorder - so that diagnosis can proceed with greater precision and so that interventions can be started earlier.",83902,COG,Cognitive Neuroscience Study Section,,2,231750,
7802980,R21,MH,5,,02/01/2010,01/31/2011,PA-06-181,5R21MH085108-02,,NIMH:151500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"FISH, KENNETH N;",2243796;,5R21MH085108,04/10/2009,01/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Acute; Affect; Aminalon; Aminalone; Ammon Horn; Anabolism; Anatomic; Anatomical Sciences; Anatomy; Antibodies; Autopsy; Axon; Axon Terminals; Body Tissues; Brain region; Butanoic acid, 4-amino-; CCK; Calcium-Binding Proteins; Cannabinoids; Cell Body; Cell Nucleus; Cells; Cholecystokinin; Code; Coding System; Confocal Microscopy; Connector Neuron; Cornu Ammonis; Corpus Striatum; Corpus striatum structure; Data; Dendrites; Dependency; Dependency (Psychology); Detection; Enzymes; Fire - disasters; Fires; Fluorescence; Future; GABA; Genes; Hippocampus; Hippocampus (Brain); Human; Human, General; Impairment; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Isoforms; Knowledge; Label; Lead; Link; M2 receptor; Mammals, Primates; Man (Taxonomy); Man, Modern; Membrane Transport Proteins; Membrane Transporters; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Messenger RNA; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microscopy, Confocal; Monkeys; Muscarinic M2 Receptor; Nerve Cells; Nerve Endings, Presynaptic; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neurocyte; Neuronal Transmission; Neurons; Nucleus; Pancreozymin; Parvalbumins; Pattern; Pb element; Pharmacological Treatment; Physiologic; Physiological; Prefrontal Cortex; Presynaptic Terminals; Primates; Probability; Process; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Pyramidal Cells; RNA, Messenger; Receptor Protein; Receptor, Muscarinic M2; Regulation; Relative; Relative (related person); Reporting; Schizophrenia; Schizophrenic Disorders; Science of Anatomy; Short-Term Memory; Site; Staining method; Stainings; Stains; Striate Body; Striatum; Structure; Surface; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; System; System, LOINC Axis 4; Techniques; Testing; Thalamic structure; Thalamus; Tissues; Transcript; Translations; Uropancreozymin; anatomy; biosynthesis; cell body (neuron); cell type; cognitive function; dementia praecox; density; design; designing; emotional dependency; flexibility; fluorescence imaging; gamma-Aminobutyric Acid; gene product; heavy metal Pb; heavy metal lead; hippocampal; human tissue; immunocytochemistry; improved; insight; mRNA; mRNA Expression; necropsy; neural cell body; neuronal; neuronal cell body; neurotransmission; non-human primate; nonhuman primate; novel; postmortem; postsynaptic; presynaptic; public health relevance; receptor; response; schizophrenic; soma; striatal; thalamic; trafficking; working memory",Differential Terminal Expression of GAD67/GAD65 ? Relevance to Schizophrenia," Project Narrative Deficits in GABA neurotransmission associated with schizophrenia are believed to contribute to the impairments in certain cognitive functions that are core features of the illness. For the most part, current pharmacological treatments for schizophrenia are ineffective at improving cognitive function. These studies will provide much needed information about the key cells, potential pharmacological targets, involved in GABA neurotransmission and how they are affected in schizophrenia.",85108,ZRG1,Special Emphasis Panel,,2,151500,
7827985,R21,MH,5,,02/01/2010,01/31/2011,PA-06-377,5R21MH085176-02,,NIMH:175779;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,MINNEAPOLIS,UNITED STATES,MISCELLANEOUS,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"LEWIS, BETH A;",6774187;,5R21MH085176,05/08/2009,01/31/2011,"0-11 years old; 21+ years old; ACOG; Adherence; Adherence (attribute); Adult; Advertisements; American; American College of Obstetricians and Gynecologists; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Birth; Breast Feeding; Breastfeeding; Child; Child Youth; Children (0-21); Clinic; Clinical; Clinics and Hospitals; Clinics or Hospitals; Conditioning Therapy; Consent; Counseling; Counselor; DSM-IV; DSM4; Depression; Depression, Postpartum; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Disease; Disorder; Emotional Depression; Epidemiology, Family Medical History; Exercise; Exercise, Physical; Family Medical History; Family history of; Gestation; Gynecologist; Health; Health Care Providers; Health Educators; Health Personnel; Healthcare Providers; Healthcare worker; History; Home; Home environment; Human, Adult; Human, Child; Intervention; Intervention Strategies; Intervention Trial; Interview; Life Style Modification; Measures; Mental Depression; Mental Health; Mental Hygiene; Mothers; Newspapers; Nutrition; Nutritional Science; Participant; Parturition; Phone; Physical activity; Pilot Projects; Post-Natal Depression; Post-Partum Depression; Postnatal Depression; Postpartum; Postpartum Depression; Postpartum Period; Postpartum Women; Pregnancy; Pregnant Women; Prevention; Preventive Intervention; Professional counselor; Psychiatry; Psychological Health; Randomized; Recommendation; Recording of previous events; Recruitment Activity; Relative; Relative (related person); Research; Risk; SCHED; Schedule; Science of nutrition; Sleep; Sports Medicine; Stress; Structure; Symptoms of depression; Telephone; Testing; Vaginal birth; Vaginal delivery; Vaginal delivery procedure; Woman; Women, Postpartum; Work; adult human (21+); base; behavior intervention; behavioral intervention; children; college; depressive; depressive symptoms; design; designing; disease/disorder; effective therapy; experience; health care personnel; health care worker; health provider; healthcare personnel; innovate; innovation; innovative; interest; interventional strategy; medical personnel; meetings; nutrition; pilot study; pregnant; prevent; preventing; preventional intervention strategy; psychologic; psychological; public health relevance; randomisation; randomization; randomized trial; randomly assigned; recruit; response; sedentary; theories; treatment provider; youngster",Efficacy of an Exercise Intervention for the Prevention of PostPartum Depression," Recent estimates indicate that approximately 10-15% of women giving birth experience depression during the postpartum period. The purpose of this study is to examine the feasibility and efficacy of an exercise intervention for the prevention of postpartum depression. If efficacious, our intervention could be disseminated in ""real world settings"" in an effort to prevent postpartum depression.",85176,PRDP,Psychosocial Risk and Disease Prevention Study Section,,2,175779,
7782783,R21,MH,5,,02/01/2010,01/31/2011,PA-06-181,5R21MH085610-02,,NIMH:231750;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,LA JOLLA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"LETENDRE, SCOTT L;",2110826;,5R21MH085610,03/09/2009,01/31/2011,"AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acquired brain injury; Acute; Address; Adhesion Molecule; Africa South of the Sahara; Anti-Retroviral Agents; Antigens; Antigens, Viral; Antiretroviral Agents; Antiretroviral Therapy, Highly Active; Area; Astrocytes; Astrocytus; Astroglia; Autoantigens; Autologous Antigens; Autopsy; Behavior; Behavioral; Blood; Blood Sample; Blood specimen; Body Tissues; Brain; Brain Injuries; CD183; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ Cell Counts; CD4+ Counts; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CKR-L2; CMKAR3; CMV; CNS Diseases; CNS disorder; CXCR3; CXCR3 gene; California; Caring; Case Study; Cell Adhesion; Cell Adhesion Molecules; Cell Mediated Immunology; Cell surface; Cell-Mediated Immunity; Cells; Cells, CD4; Cellular Adhesion; Cellular Immunity; Cellular Immunology; Cellular injury; Central Nervous System; Central Nervous System Diseases; Central Nervous System Disorders; Cerebrospinal Fluid; Cerebrum; Cessation of life; Chronic; Co-Stimulator; Cognitive; Cohort Analyses; Cohort Analysis; Communication; Costimulator; Cryptococcus neoformans; Cytokines, Chemotactic; Cytomegalovirus; Data; Death; Development; Disease; Disorder; Dysfunction; Elements; Encephalon; Encephalons; Epidermal Thymocyte Activating Factor; Esteroproteases; Fluorescence; Functional disorder; Funding; Future; GPR9; Gagging; Gliosis; HAART; HCMV; HIV; HIV therapy; HTLV-III; Highly Active Antiretroviral Therapy; Homing; Homologous Chemotactic Cytokines; Hortega cell; Human Immunodeficiency Viruses; Human Polyomavirus JC; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IFN; IL-2; IL2; IL2 Protein; INFLM; IP10; IP10-R; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune Function, Cellular; Immune System Diseases; Immune System Disorder; Immune response; Immune system; Immunity, Cellular; Immunologic Diseases; Immunologic, Immunochemical; Immunological Diseases; Immunologics; In element; Incidence; Indium; Individual; Individual Differences; Infection; Infiltration; Inflammation; Inflammatory; Infrastructure; Injury; Intercrines; Interferons; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intervention Trial; Investigation; JC Virus; Knowledge; LAV-HTLV-III; LYT3; Lead; Learning; Length of Life; Link; Longevity; Lymphadenopathy-Associated Virus; Lymphocyte; Lymphocyte Mitogenic Factor; Lymphocytic; M. tb; M. tuberculosis; M.tb; M.tuberculosis; MS (Multiple Sclerosis); Measurement; Measures; Mediating; Memory; Microglia; Mig-R; MigR; Mitogenic Factor; Multiple Sclerosis; Mycobacterium tuberculosis; Myelin; NDUL; Nerve Cells; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocognitive; Neurocyte; Neurologic; Neurological; Neuronal Injury; Neurons; Neuropsychologic Tests; Neuropsychological Tests; Nodule; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Organ; Pathogenesis; Pathway interactions; Pb element; Peptidases; Peptide Hydrolases; Peptides; Performance; Peripheral; Phenotype; Physiologic; Physiological; Physiopathology; Polyomavirus hominis 2; Polyomavirus, JC; Population; Principal Investigator; Proteases; Proteinases; Proteins; Proteolytic Enzymes; RNA, Viral; Randomized Clinical Trials; Recovery; Reflex, Pharyngeal; Regimen; Reporting; Research; Research Infrastructure; Research Resources; Resources; Reticuloendothelial System, Blood; Role; SIS cytokines; Salivary Gland Viruses; Sampling; Sclerosis, Disseminated; Self-Antigens; Staging; Sub-Saharan Africa; Subsaharan Africa; Surface; Syndrome; T cell growth factor; T memory cell; T-Cell Growth Factor; T-Cell Stimulating Factor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Subsets; T4 Cells; T4 Lymphocyte Count; T4 Lymphocytes; TEM cells; Thymocyte Stimulating Factor; Thymus-Dependent Lymphocytes; Time; Tissues; Trials, Randomized Clinical; Universities; Viral Antigens; Viral Diseases; Virus Diseases; Virus Replication; Virus-HIV; Visit; Work; anti-retroviral; anti-retroviral therapy, highly active; antiretroviral; antiretroviral therapy; base; biomarker; body system, allergic/immunologic; brain damage; brain lesion (from injury); brain tissue; case report; cell adhesion protein; cell damage; cell injury; cell type; chemoattractant cytokine; chemokine; chemokine receptor; clinical significance; clinically significant; cohort; cytokine; cytomegalovirus group; cytotoxic serine protease B; design; designing; disease/disorder; fragmentin 2; gene product; gitter cell; granzyme B; heavy metal Pb; heavy metal lead; helper T cell; host response; human cytomegalovirus; immune function; immunogen; immunoresponse; improved; insight; insular sclerosis; life span; lifespan; lymph cell; macrophage; memory T lymphocyte; mesoglia; microglial cell; microgliocyte; necropsy; neural; neurofilament; neuron injury; neuronal; neuropsychological; organ system, allergic/immunologic; partial recovery; pathogen; pathophysiology; pathway; perivascular glial cell; postmortem; public health relevance; receptor expression; reconstitute; reconstitution; relating to nervous system; response; social role; spinal fluid; terminally differentiated effector memory (TEM) T cells; terminally differentiated effector memory T cells; thymus derived lymphocyte; viral RNA; viral infection; virus RNA; virus antigen; virus infection; virus multiplication; volunteer",Antiretroviral-Induced Immune Recovery and the Central Nervous System," PROJECT NARRATIVE Immune-mediated brain injury has substantial public health relevance. Understanding mild and moderate IRD will also improve understanding of the pathogenesis of the neurological complications of HIV and other neuroinflammatory disorders. This knowledge may improve management of HAND in the U.S. and in more resource-limited settings, such as sub-Saharan Africa. This knowledge will have direct relevance for an important and still controversial question in the HIV/AIDS field, the optimal time to initiate therapy.",85610,NAED,NeuroAIDS and other End-Organ Diseases Study Section,,2,231750,
7803561,R21,MH,5,,02/01/2010,01/31/2011,PA-06-181,5R21MH086020-02,,NIMH:205000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KOLIATSOS, VASSILIS E;",2280650;,5R21MH086020,04/13/2009,01/31/2011,"21+ years old; ARIA; Acetylcholine Receptor Inducing Activity; Adult; Affect; Animal Model; Animal Models and Related Studies; Animals; BACE; BACE1; Behavior; Behavioral; Biological; Breast Cancer Cell Differentiation Factor P45; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive; Connector Neuron; Cortex, Olfactory; Data; Development; Disease; Disorder; ErbB-4; ErbB4; ErbB4 gene; GGF; Gene Deletion; Gene Expression; Generations; Genetic Models; Genotype; HER-4; HER4; Human, Adult; Intercalary Neuron; Intercalated Neurons; Interneurons; Internuncial Cell; Internuncial Neuron; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Lead; Lesion; Limbic System; Link; Maintenance; Maintenances; Mammals, Mice; Mammals, Rodents; Mental disorders; Mental health disorders; Mice; Modeling; Models, Genetic; Molecular; Molecular Target; Murine; Mus; N-Methyl-D-Aspartate Receptors; NDF; NDF Protein; NDF/Heregulin Receptor Gene; NMDA Receptor-Ionophore Complex; NMDA Receptors; NRG Proteins; NRG1; NRG1 Gene Product; NRG1 Protein; Neu-Differentiation Factor; Neural Growth; Neuregulin 1; Neuregulins; Neuronal Growth; Neuronal Plasticity; Olfactory Cortex; Outcome; Patients; Pb element; Phenotype; Predisposition gene; Process; Psychiatric Disease; Psychiatric Disorder; Psychoses; Psychotic Disorders; Pyramidal neuron; Receptors, N-Methylaspartate; Recognition (Psychology); Rodent; Rodentia; Rodentias; Role; Schizophrenia; Schizophrenic Disorders; Sensory And Motor Neuron-Derived Factor; Sensory-and-motor-derived factor; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Study Section; Susceptibility Gene; Symptoms; Transgenic Animals; Unspecified Mental Disorder; Work; adult human (21+); adult youth; basal forebrain; base; beta-secretase 1; beta-site APP cleaving enzyme 1; biological signal transduction; computerized data processing; data processing; dementia praecox; disease/disorder; endophenotype; experiment; experimental research; experimental study; gene deletion mutation; heavy metal Pb; heavy metal lead; hippocampal pyramidal neuron; interventional strategy; memapsin 2; memory recognition; mental illness; migration; model organism; neural plasticity; neurogenesis; neuroplasticity; overexpression; paracrine; piriform cortex; predisposing gene; psychological disorder; public health relevance; reconstitute; reconstitution; research study; schizophrenic; signal processing; social role; young adult",BACE1-NEUREGULIN-ErbB4 SIGNALING IN OLFACTORY MODELS OF PSYCHOSIS,"  PROJECT NARRATIVE Schizophrenia is a debilitating mental illness whose causes and mechanisms have been very difficult to decipher. A major problem in the past was the absence of animal models in which to alter the expression of genes or make lesions and then follow behaviors and study biological links (mechanisms) between interventions and outcomes. This significant obstacle is now starting to yield, with the discovery of susceptibility genes that contribute to the disease cause and the availability of transgenic animals with altered expression of these genes or their downstream molecular targets. In this application, we combine our traditional strengths in neural plasticity of the olfactory limbic system and in transgenic animal models and propose that at least a portion of psychotic symptoms may be modeled on the basis of a stalled plasticity of the olfactory cortex and its connections because of deficient signals in GABAergic cortical interneurons.",86020,ZRG1,Special Emphasis Panel,,2,205000,
7767660,R21,NS,5,,02/01/2010,01/31/2011,PAR-06-189,5R21NS059503-02,,NINDS:162422;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLUMBUS,UNITED STATES,BIOCHEMISTRY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"YOON, SUNG OK ;",6102481;,5R21NS059503,02/15/2009,01/31/2011,"21+ years old; Adult; Adverse effects; Affect; Antibodies; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Attenuated; Autoregulation; BDNF; Behavior; Behavioral; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Blood - brain barrier anatomy; Blood Plasma; Blood-Brain Barrier; Brain; Brain-Derived Neurotrophic Factor; Bruise; CYP; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cessation of life; Characteristics; Charge; Clinical Trials; Clinical Trials, Unspecified; Common Rat Strains; Contusions; Cytochromes; Cytosol; Data; Death; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dorsal Root Ganglia; Dose; Encephalon; Encephalons; Esthesia; Event; Exhibits; FLJ12099; GP80-LNGFR; Ganglia, Spinal; Glia; Glial Cells; Goals; Hair; Hemato-Encephalic Barrier; Homeostasis; Human; Human, Adult; Human, General; IP injection; In Vitro; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Injections, Intraperitoneal; Injury; Intake; Intracellular Communication and Signaling; Intraperitoneal Injections; JNK3; JNK3A; Killings; Knockout Mice; Kolliker's reticulum; Ligand Binding; Ligands; Lytotoxicity; MAPK10; MAPK10 gene; MGC34632; Mammals, Mice; Mammals, Primates; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Mechanics; Mediating; Medulla Spinalis; Mice; Mice, Knock-out; Mice, Knockout; Mitochondria; Modeling; Molecular Interaction; Motor; Movement; Murine; Mus; Myelopathy, Traumatic; NGF Receptor; NGFR; NGFR Protein; Nerve Cells; Nerve Growth Factor Receptor p75; Nerve Growth Factor Receptor, Low-Affinity; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neurotropin Receptor p75; Non-neuronal cell; Null Mouse; Oligodendrocytes; Oligodendrocytus; Oligodendroglia; Oligodendroglia Cell; Oral; PRKM10; Pain; Painful; Peptides; Physiological Homeostasis; Plasma; Play; Primates; Rat; Rattus; Receptor Protein; Receptor Signaling; Receptor, Nerve Growth Factor; Recovery; Recovery of Function; Reporting; Reticuloendothelial System, Serum, Plasma; Role; Route; Sensation; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Site; Spinal Cord; Spinal Cord Trauma; Spinal Ganglia; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Swimming; Testing; Therapeutic; Time; Toxic effect; Toxicities; Translating; Translatings; Treatment Side Effects; Walking; Weight; Work; adult human (21+); base; behavior test; behavioral test; biological signal transduction; body movement; clinical investigation; cold temperature; cytotoxicity; dorsal root ganglion; dosage; efficacy testing; function improvement; functional improvement; functional recovery; gp75 NGFR; improved; in vivo; injured; language translation; low temperature; minimally invasive; mitochondrial; nerve cement; neurodegenerative illness; neuronal; neuropathic pain; novel; p493F12; p54bSAPK; p75; p75 neurotrophin receptor; p75 transcription factor; p75(NTR); p75NTR; painful neuropathy; prevent; preventing; receptor; side effect; small molecule; social role; success; therapy adverse effect; transcriptional coactivator p75; treatment adverse effect",Promoting recovery after spinal cord injury with a targeted small molecule," NARRATIVE The proposed study will assess the potential efficacy of inhibiting death receptor signaling in the overall effort of improving locomotor function and reducing pain sensation after spinal cord injury. The compound is specifically developed based on our extensive biochemical analyses to counteract the initiating event that leads to killing the myelinating glia. This mechanism-based targeted approach suggests that severe side effect is highly unlikely because we know the target. More importantly, the compound is small and without any charge, allowing it to cross blood-brain-barrier with high efficiency. This feature is important since the compound can be delivered to the spinal cord in a non-invasive way, such as daily injections or oral intake. In addition, since myelinating glia continue to die off long after the injury, it allows us to administer therapy long after injury has taken place and potentially achieve a beneficial effect. We anticipate that a trial in primate models will be feasible in 4-5 years.",59503,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,2,162422,
7769508,R21,NS,5,,02/01/2010,01/31/2011,PAR-06-189,5R21NS060940-02,,NINDS:205673;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HANOVER,UNITED STATES,PHARMACOLOGY,02,041027822,US,NH,03755,DARTMOUTH COLLEGE,"SANCHEZ, YOLANDA ;",1879838;,5R21NS060940,02/15/2009,01/31/2011,"0-11 years old; Abscission; Active Follow-up; Address; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Affect; Alleles; Allelomorphs; Arm; Assay; Benign; Bioassay; Biologic Assays; Biological Assay; Biological Models; Cancer Treatment; Cancers; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Growth in Number; Cell Line, Tumor; Cell Migration Assay; Cell Multiplication; Cell Proliferation; Cells; Cellular Proliferation; Chemicals; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Child; Child Youth; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Combination Chemotherapy Regimen; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA Injury; Data; Dermal; Development; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening; Drug Targeting; Drug Targetings; Elephantiasis Neuromatosis; Endomycetales; Essential Genes; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Excision; Exhibits; Extirpation; Extracellular Signal-Regulated Kinase Gene; Future; GAP Proteins; GTPase-Activating Proteins; Gene Products, ras; GeneHomolog; Generalized Growth; Genes; Genes, Essential; Genes, Lethal; Genes, Neurofibromatosis 1; Genes, nf 1; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic Models; Genetic defect; Genome; Genome Instability; Genomic Instability; Goals; Growth; Hereditary; Hereditary Disease; High Throughput Assay; Homolog; Homologous Gene; Homologue; Hospitals, Pediatric; Human; Human, Child; Human, General; In Vitro; Individual; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Inherited; Intervention; Intervention Strategies; Lead; Lethal Genes; Life; Live Birth; MAP Kinase Gene; MAPK; MPNST; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Peripheral Nerve Sheath Tumor; Malignant Schwannoma; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Migration Assay; Mitogen-Activated Protein Kinase Gene; Model System; Modeling; Models, Biologic; Models, Genetic; Molecular Disease; Multiple Neurofibromas; Murine; Mus; Mutate; Mutation; NF1 gene; Nerve; Nerve Endings; Nervous; Neurilemma Cell; Neurilemmal Cell; Neurofibromatoses; Neurofibromatosis; Neurofibromatosis 1; Neurofibromatosis I; Neurofibromatosis Syndrome; Neurofibromatosis, Peripheral, NF 1; Neurofibromatosis, Peripheral, NF1; Neurofibromatosis, Type 1; Neurofibromatosis, Type I; Neuromas, Plexiform; Organ; Ortholog; Orthologous Gene; PKA; Pachydermatocele; Pathway interactions; Patients; Pb element; Pediatric Hospitals; Peripheral Neurofibromatosis; Phenotype; Plexiform Neurofibroma; Preclinical Drug Evaluation; Protein Kinase A; Proteins; Quimioterapia; Recklinghausen Disease of Nerve; Recklinghausen's disease; Recklinghausen's neurofibromatosis; Removal; Research Institute; Research Resources; Resources; S cerevisiae; Saccharomyces cerevisiae; Saccharomycetales; Schwann Cells; Screening procedure; Second Cancer; Second Primary Cancers; Secondary Malignancy; Secondary Malignancy (After Treatment of Primary Cancer); Secondary Malignant Neoplasm; Surgical Removal; System; System, LOINC Axis 4; Therapeutic; Tissue Growth; Tumor Cell; Tumor Cell Line; Tumor Royale; Tumor Tissue; Upper arm; Validation; Work; Xenograft Model; Yeast Model System; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; YeastModel; Yeasts; anticancer therapy; cAMP-Dependent Protein Kinases; cancer chemotherapy; cancer therapy; children; clinical investigation; design; designing; disease/disorder; drug development; feeding; follow-up; gene product; genetic disorder; genome mutation; guanosinetriphosphatase activating protein; heavy metal Pb; heavy metal lead; hereditary disorder; high throughput screening; inhibitor; inhibitor/antagonist; interventional strategy; loss of function mutation; malignancy; migration; mutant; neoplasm/cancer; neoplastic cell; neurofibroma; neurofibromatosis type 1 gene; new approaches; novel approaches; novel strategies; novel strategy; ontogeny; pathway; psychologic; psychological; public health relevance; ras Proteins; resection; screening; screenings; secondary cancer; senescence; therapeutic target; von Recklinghausen Disease; youngster",Identification of Drug Targets for NF1," NF1 is an inherited disease that affects 1:3500 live births in which 95% of carriers develop neurofibromas that include plexiform neurofibromas. Plexiform neurofibromas can cause disfigurement and/or compression of organs with devastating consequences. Despite the fact that NF1 is one of the most frequently inherited genetic disorders and that the gene involved in the disease is known, currently there is no effective pharmacological therapy for NF1. This proposal addresses two hurdles in the identification of therapies for NF1. The first hurdle is the lack of a system that allows identification of therapies specific to cells with NF1 mutations and the second is the need for a resource amenable to high throughput drug screens. The work proposed here takes a two-pronged approach using human cells and a genetic model system, the yeast for the identification of drug targets for NF1. There is no better model than the yeast for these types of screens, thus by combining these two models we present a powerful approach for screening compounds to identify and validate potential drug targets for NF1.",60940,ZNS1,Special Emphasis Panel,,2,205673,
7766940,R21,NS,5,,02/01/2010,01/31/2011,PAR-06-189,5R21NS061069-02,,NINDS:170348;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CHARLOTTESVILLE,UNITED STATES,ANESTHESIOLOGY,05,065391526,US,VA,229044195,UNIVERSITY OF VIRGINIA CHARLOTTESVILLE,"PATEL, MANOJ K;",6984717;,5R21NS061069,02/15/2009,01/31/2011,"2,4-Imidazolidinedione, 5,5-diphenyl-; 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; 5,5-Diphenylhydantoin; 5H-Dibenz(b,f)azepine-5-carboxamide; Action Potentials; Adverse effects; Affect; American; Animal Model; Animal Models and Related Studies; Animals; Anti-epileptic; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Assay; Bioassay; Biologic Assays; Biological Assay; Brain; Carbamazepine; Chronic; Common Rat Strains; Data; Desitin Brand of Lamotrigine; Development; Diagnosis; Dilantin; Diphenylhydantoin; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Epilepsy; Epilepsy, Temporal Lobe; Epileptic Seizures; Epileptics; Epitol; Fenitoin; Generations; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Human; Human, General; Ion Channels, Sodium; Isoforms; Lamictal; Lamiktal; Life; Link; Mammals, Rats; Man (Taxonomy); Man, Modern; Medication; Modeling; Na element; Nerve Cells; Nerve Unit; Nervous System Diseases; Nervous System, Brain; Neural Cell; Neurocyte; Neurologic Disorders; Neurological Disorders; Neurons; Neurophysiology / Electrophysiology; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Phenytoin; Preclinical Testing; Protein Isoforms; Public Health; Rat; Rattus; Refractory; Resistance; Science of Statistics; Screening procedure; Seizure Disorder; Seizures; Series; Slice; Sodium; Sodium Channel; Sodium Channel Blockers; Statistics; Tegretol; Temporal Lobe Epilepsy; Testing; Therapeutic; Therapeutic Index; Therapeutic Uses; Treatment Side Effects; Validation; candidate identification; channel blockers; cost; drug detection; drug testing; drug use screening; drug/agent; epilepsia; epileptiform; epileptogenic; experience; lamotrigine; model organism; nervous system disorder; neurological disease; neuronal; neuronal excitability; novel; pre-clinical; preclinical; public health medicine (field); public health relevance; resistance to therapy; resistant; resistant to therapy; screening; screenings; side effect; statistics; therapy adverse effect; therapy resistant; treatment adverse effect",Development of Novel Antiepileptic Drugs," Epilepsy, a neurological disorder, is a major public health issue affecting over 2 million Americans. Approximately 750,000 Americans experience seizures that cannot be suppressed by currently available drugs. The patients continue to experience un-controlled, life threatening, epileptic seizures. In this exploratory/developmental proposal, we will develop a drug testing screen that will identify drugs that are effective in epileptic neurons. These drugs could be effective in patients that are ""pharmaco-resistant"" to currently available drugs.",61069,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,2,170348,
7675932,R21,NS,5,,12/01/2009,11/30/2010,PA-06-181,5R21NS061998-02,,NINDS:178487;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","KOVTUN, IRINA V;",8574787;,5R21NS061998,12/01/2008,11/30/2010,"Accounting; Affect; Age; Age of Onset; Aging; Alleles; Allelomorphs; Anaplastic; Animal Model; Animal Models and Related Studies; Anticipation, Genetic; Area; Automobile Driving; Bacteria; Brain; Cell Communication and Signaling; Cell Cycle; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Division Cycle; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell division; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; DNA; DNA Damage Repair; DNA Repair; DNA Replication; DNA Synthesis; DNA biosynthesis; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Deoxyribonucleic Acid; Detection; Development; Disease; Disorder; Drivings, Automobile; ES Cell Line; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Embryonic Stem Cell Line; Encephalon; Encephalons; Equilibrium; Event; Expanded Trinucleotide Repeat; Fibroblasts; Gametes; Generations; Genes; Genetic; Genetic Alteration; Genetic Anticipation; Genetic Change; Genetic defect; Genome Stability; Germ; Germ Cells; Germ-Line Cells; Goals; Hand; Hereditary; Hot Spot; Hot Spots (Area of Increased Mortality); Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Inherited; Interphase Cell; Intracellular Communication and Signaling; Knock-in; Knock-in Mouse; Length; Light; M Phase; M phase (cell cycle); MMR; Maintenance; Maintenances; Mammalia; Mammalian Cell; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Measures; Mice; Mismatch Repair; Mitosis; Mitosis Stage; Modeling; Molecular; Molecular Target; Murine; Mus; Mutation; Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Non-dividing Cell; Organism; Parents; Phase; Photoradiation; Plasmids; Play; Post-Replication Mismatch Repair; Process; Progressive Chorea, Hereditary, Chronic (Huntington); Proteins; Reproductive Cells; Research; Resting Cell; Role; Senescence; Severity of illness; Sex Cell; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Somatic Cell; Stability, Genomic; Structure; Subcellular Process; System; System, LOINC Axis 4; Testing; Time; Transgenes; Transgenic Organisms; Trinucleotide Repeat Expansion; Trinucleotide Repeats; Triplet Repeats; Undifferentiated; Unscheduled DNA Synthesis; Yeasts; balance; balance function; biological signal transduction; codon reiteration; cultured cell line; disease severity; disease/disorder; driving; dynamic mutation; experiment; experimental research; experimental study; gene product; genome mutation; in vivo Model; initial cell; insight; living system; model organism; mouse model; mutant; neurodegenerative illness; offspring; prevent; preventing; public health relevance; repair; repair endonuclease; repair enzyme; repaired; research study; senescent; sexual cell; social role; transgenic",Cell Cycle Control of Trinucleotide Instability in Mammalian Cells," Trinucleotide repeat expansion mutation is the cause of a number of inherited neurodegenerative diseases. This is dynamic mutation which worsens in succeeding generations. Expansion has been shown to occur in germ cells of the transmitting parent and in the affected by the disease areas of the brain of the offspring. Two cellular processes have been demonstrated in different model organisms to contribute to repeat expansion, that is DNA replication and DNA repair. These processes are likely differentially used in dividing and non-dividing cells. We have shown previously that repeat expansion occurs in non-dividing cells as they try to repair DNA damage while repeat contraction can occur in dividing cells and involves DNA replication. The latter is limited to a very short time window in early embryogenesis. It is not known how the machinery which regulates cell division,-cell cycle control,-affects stability of the triplet repeats in early development. In this proposal we will determine the role of cell cycle control proteins in triplet repeat instability by establishing mouse embryonic stem cell lines and studying changes in repeat length during cell division (Aim 1). Using this model we will test whether manipulations with cell cycle control machinery (Aim 2) can shift repeat number towards contractions that is advantageous for the survival of the cells which carry long triplet repeats. The proposed experiments will advance our understanding of the mechanism of triplet repeat instability and point towards avenues to explore molecular targets important for preventing expansion.",61998,NDT,Nuclear Dynamics and Transport,,2,178487,
7758296,R21,NS,5,,01/01/2010,12/31/2010,PA-06-181,5R21NS063029-02,,NINDS:134269;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,ATLANTA,UNITED STATES,PHARMACOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"HALL, RANDY A.;",1889844;,5R21NS063029,01/15/2009,12/31/2010,"Adhesions; Agonist; Arrestins; Asperger Syndrome; Asperger's Disorder; Assay; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Bilateral; Bioassay; Biologic Assays; Biological Assay; Cell Communication and Signaling; Cell Culture Techniques; Cell Signaling; Cell membrane; Cells; Cerebral cortex; Cleaved cell; Co-Immunoprecipitations; Cognitive; Complex; Cytoplasmic Membrane; Cytoplasmic Protein; Development; Disease; Disorder; EC 2.7; Exhibits; Family; G Protein-Complex Receptor; G Protein-Coupled Receptor, Family C, Group 5, Member C; G protein coupled receptor kinase; G protein-coupled receptor, family C, group 5, member C, human; G-Protein-Coupled Receptors; GPRC5C; GPRC5C protein, human; Genetic; Genetic Alteration; Genetic Change; Genetic Condition; Genetic Diseases; Genetic defect; Hereditary; Hereditary Disease; Human; Human, General; Image; Inherited; Intracellular Communication and Signaling; Kanner's Syndrome; Kinases; Knowledge; Lead; Length; Ligands; Light; Man (Taxonomy); Man, Modern; Maps; Mediating; Microgyria; Molecular Disease; Mutation; N-terminal; NH2-terminal; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurodevelopmental Disorder; Neurological Development Disorder; Neurons; Orphan; Orphan G-Protein Coupled Receptor; Patients; Pb element; Peptides; Phosphorylation; Phosphotransferases; Photoradiation; Plant Roots; Plasma Membrane; Play; Polymicrogyria; Process; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Proteomics; RAIG-3 protein, human; RNA, Small Interfering; Receptor Activation; Receptor Protein; Receptor Signaling; Regulation; Retinoic Acid Responsive Gene Protein; Role; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Syndrome; Testing; Transfection; Transphosphorylases; biological signal transduction; cleaved; desensitization; developmental disease/disorder; developmental disorder; disease/disorder; experiment; experimental research; experimental study; extracellular; gene product; genetic disorder; genome mutation; heavy metal Pb; heavy metal lead; hereditary disorder; human GPRC5C protein; human disease; imaging; insight; member; mutant; neuronal; peptidomimetics; plasmalemma; public health relevance; receptor; research study; rho; root; scaffold; scaffolding; siRNA; social role; trafficking",Fundamental Mechanisms of GPR56 Activation and Regulation," Project Narrative  Abnormalities in the development of the cerebral cortex can lead to a range of distinct neurodevelopmental disorders, including autism and Asperger's syndrome. To shed light on the factors that contribute to such diseases, we propose to study the fundamental properties of the orphan receptor GPR56, which is believed to play a key role in cortical development since mutations in GPR56 cause a rare genetic disorder in which the development of the cerebral cortex is grossly distorted. Knowledge gained from these studies focused on the normal function of GPR56 will provide fresh insights into the role of GPR56 in human disease and also into the fundamental mechanisms that regulate the development of the cerebral cortex.",63029,MNPS,Molecular Neuropharmacology and Signaling Study Section,,2,134269,
7766209,R21,NS,5,,02/01/2010,01/31/2011,PA-06-181,5R21NS063192-02,,NINDS:177897;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WORCESTER,UNITED STATES,PHYSIOLOGY,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"LEMOS, JOSE R;",1863736;,5R21NS063192,02/15/2009,01/31/2011,"ALS; Affect; Aging; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amyotrophic Lateral Sclerosis; Area; Argipressin; Attention; Blood Coagulation Factor IV; Brain; Ca Release Channel-Ryanodine Receptor; Ca++ element; Calcium; Calcium-Ryanodine Receptor Complex; Capacitance, Electrical; Cells; Central Nervous System; Chemotherapy-Hormones/Steroids; Coagulation Factor IV; Communication; Coupled; Cytosol; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Disease; Disorder; Eaton-Lambert Syndrome; Electric Capacitance; Electron Microscopy; Encephalon; Encephalons; Endocrine Gland Secretion; Event; Exocytosis; Factor IV; Fluo-3; Fluorescence Microscopy; Frequencies (time pattern); Frequency; Gehrig's Disease; Goals; Hormones; Image; Individual; Kinetic; Kinetics; Knowledge; Lambert-Eaton Myasthenic Syndrome; Lipid Bilayers; Location; Lou Gehrig Disease; Mammals, Mice; Measurement; Membrane; Methods and Techniques; Methods, Other; Mice; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Monitor; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Murine; Mus; Muscle; Muscle Tissue; Myopathic-Myasthenic Syndrome of Lambert-Eaton; Nerve; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Nervous System, CNS; Neural Cell; Neuraxis; Neurocyte; Neurons; Neuropeptides; Neurosecretory Granule; Neurotransmitters; OXT; Ocytocin; Oxytocin; Pathology; Peptides; Physiologic; Physiological; Physiology; Play; Preparation; Primary Senile Degenerative Dementia; Process; Receptors, Ryanodine; Recombinant Oxytocin; Resolution; Role; Ryanodine; Ryanodine Receptor; Ryanodine Receptor Calcium Release Channel; Ryanodine Receptors; Ryanodol, 3-(1H-pyrrole-2-carboxylate); Secretory Granules; Secretory Vesicles; Senescence; Source; Stimulus; Synapses; Synaptic; Techniques; Therapeutic Hormone; Time; V (voltage); VESCL; Vasopressin, 8-L-arginine-; Vasopressin, Arginine; Vasopressin-Neurophysin II-Copeptin; Vesicle; Work; capacitance; controlled release; dementia of the Alzheimer type; disease/disorder; extracellular; imaging; immunocytochemistry; lipid bilayer membrane; membrane structure; neuronal; neurotransmitter release; novel; peptide hormone; primary degenerative dementia; public health relevance; senescent; senile dementia of the Alzheimer type; social role; voltage",Peptide Release Regulated by Ca2+ from Neurosecretory Granules," PROJECT NARRATIVE Communication both within the brain and with its targets is via release of transmitters at nerve terminals, and such release is known to be dependent on the entry of extracellular calcium and the subsequent elevation of intraterminal calcium. We have recently shown that nerve terminals have intracellular calcium stores and in this proposal we utilize novel techniques to determine what are these intraterminal stores and whether they can regulate the release of transmitters from nerve terminals. This knowledge could prove to be important for the understanding and treatment of synaptic diseases such Eaton-Lambert Syndrome and Amyotrophic Lateral Sclerosis, as well as Alzheimer's disease and neuronal aging.",63192,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,2,177897,
7751919,R21,NS,5,,01/01/2010,12/31/2010,PA-06-181,5R21NS064381-02,,NINDS:184078;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"STRASSMAN, ANDREW MARK;",1893618;,5R21NS064381,01/01/2009,12/31/2010,"Body Tissues; Brain Stem; Brainstem; Cephalalgia; Cephalgia; Cephalodynia; Cephalodynias; Classification; Clinical; Cornea; Cranial Pain; Cutaneous; Data; Development; Dorsal Horn Cells; Drugs; Dura; Dura Mater; Equilibrium; Ethyl Carbamate; Ethyl Urethan; Event; Face; Frequencies (time pattern); Frequency; Head Pain; Headache; Headache, Migraine; In Vitro; Inflammation Mediators; Injection of therapeutic agent; Injections; Investigation; Label; Lead; Location; Mammals, Mice; Maps; Measurement; Measures; Mechanics; Mediating; Mediation; Medication; Methods and Techniques; Methods, Other; Mice; Migraine; Morphology; Murine; Mus; Negotiating; Negotiation; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neurons; Neurons, Dorsal Horn; Neurons, Posterior Horn; Nociception; Pain; Painful; Pathogenesis; Pattern; Pb element; Peripheral; Pharmaceutic Preparations; Pharmaceutical Preparations; Posterior Horn Cells; Process; Property; Property, LOINC Axis 2; Research; Sensory; Site; Slice; Staining method; Stainings; Stains; Stimulus; Synapses; Synaptic; Systematics; Techniques; Testing; Time; Tissues; Transmission; Trigeminal System; Urethane; V (voltage); allodynia; balance; balance function; base; carbamic acid, ethyl ester; central sensitization; corneal; dorsal horn; drug/agent; experiment; experimental research; experimental study; extracellular; facial; heavy metal Pb; heavy metal lead; in vivo; insight; neuronal; nociceptive; novel; patch clamp; public health relevance; receptive field; research study; response; transmission process; trigeminal; voltage; voltage clamp",In Vivo Patch Clamp Studies of Dorsal Horn Neurons in Relation to Headache," This project will give new insight into the cellular mechanisms underlying the phenomenon of central sensitization of pain-transmitting neurons, which is now thought to be an important component of migraine as well as many other pain conditions. This information will lead to better understanding of migraine headache, and will be important for devising strategies for development of new drug treatments.",64381,SCS,Somatosensory and Chemosensory Systems Study Section,,2,184078,
7760594,R21,NS,5,,02/01/2010,01/31/2011,PA-08-098,5R21NS065091-02,,NINDS:215047;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW HAVEN,UNITED STATES,ANESTHESIOLOGY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"MA, CHAO ;",7888892;,5R21NS065091,02/01/2009,01/31/2011,"ATGN; Acute; Affect; Afferent Neurons; Affinity; Allergic; Ambrosia; Animals; Antigen-Antibody Complex; Antigens; Autoimmune; Autoimmune Process; Behavior; Blood Serum; Body Tissues; Cell Body; Cell/Tissue, Immunohistochemistry; Cells; Common Rat Strains; Communicable Diseases; Control Animal; Cutaneous; Data; Development; Disease; Disorder; Dorsal Root Ganglia; Drug Administration, Topical; Electrophysiology; Electrophysiology (science); Exhibits; Exploratory/Developmental Grant; Fc Receptor; FcR; Future; Gamma Globulin, 7S; Ganglia, Sensory; Ganglia, Spinal; Hyperalgesia; Hyperalgesic Sensations; IHC; INFLM; IgG; IgG Receptors; Immune; Immune Complex; Immune response; Immunoglobulin G; Immunoglobulin G Receptor; Immunohistochemistry; Immunohistochemistry Staining Method; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Location; Mammals, Rats; Measures; Methods; Monitor; Nerve Cells; Nerve Tissue; Nerve Unit; Nervous Tissue; Neural Cell; Neurochemistry; Neurocyte; Neurons; Neurons, Afferent; Neurons, Sensory; Neurophysiology / Electrophysiology; Nociception; Pain; Painful; Peripheral; Phase; Physiologic; Physiological; Pollen; Property; Property, LOINC Axis 2; R21 Mechanism; R21 Program; Ragweed; Rat; Rattus; Receptors, IgG; Role; Science of neurochemistry; Sensory; Sensory Cell Afferent Neuron; Sensory Ganglia; Serum; Skin; Spinal Ganglia; Stimulus; Time; Tissues; Topical application; Up-Regulation; Up-Regulation (Physiology); Upregulation; antibody receptor; behavior test; behavioral test; cell body (neuron); chronic pain; chronic painful condition; disease/disorder; dorsal root ganglion; gamma Fc Receptors; host response; hyperalgia; immunogen; immunoreactivity; immunoresponse; in vivo; neural cell body; neurochemistry; neuronal; neuronal cell body; neuronal excitability; new therapeutics; next generation therapeutics; nociceptive; novel; novel therapeutics; public health relevance; response; social role; soma; topical administration; topical drug application; topically applied",Antigen-specific immune mechanisms of neuronal hyperexcitability and chronic pain, NARRATIVE  This study will reveal a novel mechanism of chronic pain driven by the antigen-specific immune response via the effects of IgG immune complex on the Fc receptors expressed in primary sensory neurons. It will provide potentially new therapeutic strategies in the treatment of chronic pain.,65091,SCS,Somatosensory and Chemosensory Systems Study Section,,2,215047,
7762743,R21,NS,5,,02/01/2010,01/31/2011,PA-06-181,5R21NS065405-02,,NINDS:175849;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,NEW YORK,UNITED STATES,PHYSIOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"BOUDKER, OLGA  (contact);CARTER, NICOLA S.;",8865038 (contact);9506936;,5R21NS065405,02/01/2009,01/31/2011,"3-D structure; 3-dimensional structure; 3D structure; Achievement; Achievement Attainment; Adenosine; Adopted; Affinity; Amino Acids; Antiparasitic Agents; Antiparasitic Drugs; Antiparasitics; Antiviral Agents; Antiviral Drugs; Antivirals; Apoplexy; Binding; Binding (Molecular Function); Biological; Bizzozero's corpuscle/cell; Blood Platelets; Body Temperature; Brain; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cellular Membrane; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Crystallization; Cytoplasmic Membrane; Deetjeen's body; Detergents; Dipyramidole; Dipyridamole; Drugs; Dysfunction; Encephalon; Encephalons; Epilepsy; Epileptic Seizures; Epileptics; Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-; Exhibits; Family; Family member; Functional disorder; GeneHomolog; Genetic Alteration; Genetic Change; Genetic Engineering of Proteins; Genetic defect; Genetics-Mutagenesis; Goals; Hayem's elementary corpuscle; Homolog; Homologous Gene; Homologue; Human; Human, General; Idiopathic Parkinson Disease; Immunosuppressants; Immunosuppressive Agents; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Lewy Body Parkinson Disease; Ligand Binding; Ligands; Lipid Bilayers; Lipids; Location; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Marrow platelet; Mediating; Medical; Medication; Membrane Proteins; Membrane Transport Proteins; Membrane Transporters; Membrane-Associated Proteins; Molecular; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Mutagenesis; Mutate; Mutation; Nature; Nervous System, Brain; Nucleoside Transport Proteins; Nucleoside Transporter; Pain; Painful; Paralysis Agitans; Parasiticides; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Perception; Persantin; Persantine; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiology; Physiopathology; Plasma Membrane; Platelets; Predisposition; Prevention; Primary Parkinsonism; Process; Production; Protein Dynamics; Protein Engineering; Proteins; Protocol; Protocols documentation; Reticuloendothelial System, Platelets; Route; Seizure Disorder; Seizures; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Sleep; Solutions; Stroke; Structure; Supplementation; Surface Proteins; Susceptibility; Synapses; Synaptic; TM Domain; Thrombocytes; Thrombus; Transmembrane Domain; Transmembrane Protein; Transmembrane Region; Variant; Variation; Vascular Accident, Brain; Vasodilatation; Vasodilation; Vasorelaxation; Yeasts; aminoacid; base; biological signal transduction; brain attack; cerebral vascular accident; conformation; conformational state; drug/agent; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; extracellular; gene product; genome mutation; immunosuppressive; inhibitor; inhibitor/antagonist; lipid bilayer membrane; loss of function; milligram; mutant; neurological pathology; nucleoside analog; pathophysiology; plasmalemma; prevent; preventing; public health relevance; research study; reuptake; stroke; structural biology; success; three dimensional structure; thrombocyte/platelet; uptake",Crystallographic studies of equilibrative nucleoside transporters," PROJECT NARRATIVE Adenosine is an important signaling molecule in humans, regulating a wide range of effects such as vasodilatation, thrombus formation, pain perception, sleep cycle, and body temperature. Specialized proteins in the cellular membranes, equilibrative nucleoside transporters control the levels of adenosine available for signaling. They are the targets of many drugs such as dipyridamole, which is widely used to prevent secondary strokes. Here we propose to crystallize these molecules, an essential step toward determination of their atomic structure, which in itself is essential to understand the transporters mechanism and to increase our capacity to pharmacologically control their function.",65405,BBM,Biochemistry and Biophysics of Membranes Study Section,,2,175849,
7786287,R21,RR,5,,03/01/2010,02/28/2011,RR-06-004,5R21RR024439-03,,NCRR:178707;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,EAST LANSING,UNITED STATES,ENGINEERING (ALL TYPES),08,193247145,US,MI,48824,MICHIGAN STATE UNIVERSITY,"WALTON, STEPHEN PATRICK;",6368143;,5R21RR024439,03/06/2008,02/28/2011,"(S)-Lactate[{..}]NAD+ oxidoreductase; 3'5'-cyclic ester of AMP; 9-cis-Retinoic Acid Receptor; AIDS; ATF-1; ATF1; Abbreviations; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affinity; Assay; Band Shift Mobility Assay; Bandshift Mobility Assay; Base Pairing; Behavior; Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Biological Models; CRE; CRE Binding Protein; CREB; CREB Protein; Cachectin; Cachectin-Tumor Necrosis Factor; Cancers; Cell Communication and Signaling; Cell Function; Cell Line; Cell Lines, Strains; Cell Process; Cell Signaling; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Complement; Complement Proteins; Computer Systems Development; Consensus; Consensus Sequence; ConsensusSequence; Cyclic AMP; Cyclic AMP Response Element; Cyclic AMP Response Element-Binding Protein; Cyclic AMP Responsive Element Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; DIF; DNA Binding; DNA Binding Interaction; Detection; Development; Development, Computer Systems; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Dissociation; EC 1.1.1.27; EMSA; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Elements; Environment; Equilibrium; Event; Fatty Acids; Fatty Acids, Nonesterified; Fractionation, Polyacrylamide Gel; Free Fatty Acids; Future; Genetic; Genomics; Global Change; Hepatic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Human; Human, General; Immunoglobulin Enhancer-Binding Protein; Immunologic Deficiency Syndrome, Acquired; In Vitro; Individual; Intracellular Communication and Signaling; L-Lactate Dehydrogenase; L-Lactic Acid Dehydrogenase; LDH; LPS; Label; Lactate Dehydrogenase; Ligand Binding Protein; Lipopolysaccharides; Liver; Liver Cells; Lytotoxicity; MODY; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Methods and Techniques; Methods, Other; Mobility Shift Assay; Model System; Modeling; Models, Biologic; Molecular; NAD-Lactate Dehydrogenase; NF-kB; NF-kappa B; NF-kappaB; NFKB; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Nuclear; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nucleic Acids; PCR; PPAR; Peroxisome Proliferator-Activated Receptors; Phase; Polyacrylamide Gel Electrophoresis; Polymerase Chain Reaction; Predictive Value; Property; Property, LOINC Axis 2; Protein Analysis; Proteins; RXR; RXR Protein; Reading; Receptor Protein; Reproducibility; Research; Retinoic Acid Receptor RXR; Retinoid X Receptors; Sampling; Sensitivity and Specificity; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Specificity; Sterols; Stimulus; Subcellular Process; System; System, LOINC Axis 4; Systems Development; T2D; T2DM; TNF; TNF (unspecified); TNF A; TNF Receptor Ligands; TNF gene; TNF-alpha; TNFSF2; Techniques; Testing; Time; Transcription Factor NF-kB; Translating; Translatings; Triacylglycerol; Triglycerides; Tumor Necrosis Factor; Tumor Necrosis Factor Family Protein; Tumor Necrosis Factor Gene; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Type 2 diabetes; Type II diabetes; Work; activating transcription factor 1; adenosine 3'5' monophosphate; adult onset diabetes; balance; balance function; base; biological signal transduction; body system, hepatic; cAMP; cAMP Response Element; cAMP Response Element-Binding Protein; cAMP Responsive Element Binding Protein; cultured cell line; cytokine; cytotoxicity; disease/disorder; extracellular; gel shift assay; gene product; hepatoma cell; improved; kappa B Enhancer Binding Protein; ketosis resistant diabetes; lactic acid dehydrogenase; language translation; malignancy; maturity onset diabetes; neoplasm/cancer; nuclear factor kappa beta; organ system, hepatic; protein expression; receptor; response; tool; transcription factor; tumor necrosis factor (unspecified)","Development of a parallel, array-based transcription factor expression assay",,24439,ZRR1,Special Emphasis Panel,,3,178707,
7777889,R21,RR,5,,03/01/2010,02/28/2011,RR-08-001,5R21RR024449-02,,NCRR:183026;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,CLEMSON,UNITED STATES,BIOMEDICAL ENGINEERING,03,042629816,US,SC,296345702,CLEMSON UNIVERSITY,"VERTEGEL, ALEXEY A;",8573455;,5R21RR024449,03/01/2009,02/28/2012,"Actin Filaments; Address; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Atomic Force Microscope; Atomic Force Microscopy; Behavior; Biological; Biological Function; Biological Models; Biological Process; Biosensing Technics; Biosensing Techniques; Blood Vessels; Body Tissues; Calcified; Cell Culture Techniques; Cells; Collagen Fibril; Computer Programs; Computer software; Coupling; Culture Media; Development; Diagnosis; Diagnostic; Diagnostic Method; Diagnostic Procedure; Diagnostic Technique; Dysfunction; Electrolytes; Electron Beam; Elements; Environment; Force Microscopy; Functional disorder; Future; Goals; H+ element; Heart; Hydrogen Ions; Image; Individual; Injury; Investigation; Ion Channel; Ionic Channels; Leiomyocyte; Length; Life; Liquid substance; Maps; Mechanics; Medical; Membrane Channels; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Micro-tubule; Microfilaments; Microscopy, Atomic Force; Microscopy, Scanning Probe; Microtubules; Model System; Modeling; Models, Biologic; Molecular; Motor; Muscle Cells; Muscle Cells, Mature; Myocytes; Myocytes, Smooth Muscle; Myofilaments; Operation; Operative Procedures; Operative Surgical Procedures; Patch-Clamp Technics; Patch-Clamp Techniques; Pathologic Processes; Pathological Processes; Phenotype; Physiologic; Physiological; Physiopathology; Play; Process; Property; Property, LOINC Axis 2; Proteins; Protons; Reaction; Resolution; Role; Scanning Force Microscopy; Scanning Probe Microscopy; Sight; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Software; Solutions; Stimulus; Structure; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Techniques; Testing; Tissue Engineering; Tissues; V (voltage); Vision; aqueous; atheromatosis; atherosclerotic vascular disease; base; biological systems; biosensing; cell behavior; cell type; computer program/software; design; designing; electric field; engineered tissue; epiligrin; fluid; gene product; growth media; imaging; instrument; kalinin; laminin-5; liquid; member; molecular shape; nano meter scale; nano meter sized; nano scale; nanometer scale; nanometer sized; nanoscale; new diagnostics; next generation diagnostics; nicein; novel diagnostics; novel therapeutic intervention; pathophysiology; prevent; preventing; public health relevance; response; restenosis; social role; sub micron; submicron; success; surgery; tool; vascular; voltage",Electromechanical Imaging of Live Vascular Smooth Muscle Cells,,24449,ZRR1,Special Emphasis Panel,,2,183026,
7786194,R21,RR,5,,03/01/2010,02/28/2011,PA-07-336,5R21RR025915-02,,NCRR:179966;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,AMES,UNITED STATES,GENETICS,04,005309844,US,IA,500112207,IOWA STATE UNIVERSITY,"ESSNER, JEFFREY J;",7798323;,5R21RR025915,03/01/2009,02/28/2011,"Address; Agriculture; Allelism Test; Animal Model; Animal Models and Related Studies; Animals; Biological Models; Brachydanio rerio; Cells; Chimera Protein; Chimeric Proteins; Cloning; Complementation Test; DNA; DNA Binding Domain; DNA Molecular Biology; DNA Recombination; DNA recombination (naturally occurring); DNA, Single-Stranded; Danio rerio; Deoxyribonucleic Acid; Development; Double Strand Break Repair; ES cell; Embryo; Embryonic; Engineering; Engineerings; Enzymes; Eukaryota; Eukaryote; Event; Filament; Frequencies (time pattern); Frequency; Fusion Protein; Gene Conversion; Gene Targeting; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; GeneHomolog; Generations; Genes; Genes, Reporter; Genetic; Genetic Alteration; Genetic Change; Genetic Complementation Test; Genetic Intervention; Genetic Recombination; Genetic Screening; Genetic defect; Genome; Genome, Human; Genomics; Goals; Grant; Head; Health; Homolog; Homologous Gene; Homologous Recombinational Repair; Homologue; Human; Human Genome; Human, General; Induced DNA Alteration; Induced Mutation; Induced Sequence Alteration; Injection of therapeutic agent; Injections; Intervention, Genetic; Laboratories; Location; Man (Taxonomy); Man, Modern; Mediating; Methods; Methods and Techniques; Methods, Other; Microinjections; Mitotic; Model System; Modeling; Models, Biologic; Modification; Molecular; Molecular Biology; Molecular Biology, Gene Therapy; Mutagenesis, Site-Directed; Mutate; Mutation; NLS Peptide; Names; Nature; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Optics; Pathway interactions; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Principal Investigator; Probability; Production; Programs (PT); Programs [Publication Type]; Protein Motifs, DNA-Binding; Proteins; Rec A Protein; Rec A Recombinases; RecA Protein; Recombination; Recombination Repair; Recombination, Genetic; Reporter Genes; Role; Scientist; Single-Stranded DNA; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Specific qualifier value; Specified; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Targetings, Gene; Techniques; Technology; Testing; Therapy, DNA; Trans Test; Work; Zebra Danio; Zebra Fish; Zebrafish; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; agricultural; base; cost; design; designing; developmental genetics; drug discovery; embryo cell; embryonic stem cell; eukaryotida; experience; experiment; experimental research; experimental study; gene product; gene therapy; genetic therapy; genome mutation; human disease; insertion-deletion; insertion-deletion mutation; insertion/deletion; insertion/deletion mutation; interest; model organism; mutant; next generation; nuclease; pathway; positional cloning; programs; protein purification; public health relevance; recombinase; recombinational repair; repair; repaired; research study; reverse genetics; skills; social role; stem cell of embryonic origin; success; tool; zebrafish genome",Use of RecA to Promote Gene Targeting, We propose to develop methods in zebrafish that utilize the bacterial recombinase protein RecA to create site directed modification of the genome. These techniques have the potential to revolutionize reverse genetic approaches in all animal models of human disease. Successful completion of this proposal will have a profound impact on the identification of pharmaceutical targets for drug discovery and the production of new animal models of human disease.,25915,ZRG1,Special Emphasis Panel,,2,179966,
7753147,R24,DA,5,,12/01/2009,11/30/2010,PAR-02-016,5R24DA018055-05,,NIDA:429901;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,PHYSIOLOGY,15,603503991,US,NY,10031,CITY COLLEGE OF NEW YORK,"FRIEDMAN, EITAN ;",7808606;,5R24DA018055,06/01/2005,11/30/2010,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; American; Area; Biochemistry; Biologic Sciences; Biological; Biological Sciences; Biology; Biomedical Engineering; Biophysics; Brain Diseases; Brain Disorders; CCL7; CCL7 gene; Career Choice; Cell Nucleus; Chemistry; Chemistry, Biological; Cities; Cocaine; Collaborations; Commit; Core Facility; D1 receptor; DNA Molecular Biology; Dedications; Development; Development and Research; Dopamine D1 Receptor; Drug abuse; Dysfunction; EXTMR; Education; Educational aspects; Educational workshop; Encephalon Diseases; Environment; Extracellular Signal-Regulated Kinase Gene; Extramural; Extramural Activities; Faculty; Financial Support; Fostering; Functional disorder; Funding; Future; Goals; History; Immigrant; Individual; Infrastructure; Institution; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; Investigation; Investigators; Laboratories; Leadership; Life Sciences; Location; MAP Kinase Gene; MAPK; MARC; MCP-3; MCP3; Measures; Mentors; Minority; Mission; Mitogen-Activated Protein Kinase Gene; Molecular; Molecular Biology; N-Methyl-D-Aspartate Receptors; NC28; NIDA; NIH; NMDA Receptor-Ionophore Complex; NMDA Receptors; National Institute of Drug Abuse; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Unit; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; New York; Nucleus; Operation; Operative Procedures; Operative Surgical Procedures; Participant; Perinatal Exposure; Pharmacology; Physiology; Physiopathology; Population; Position; Positioning Attribute; Productivity; Program Evaluation; Programs (PT); Programs [Publication Type]; Psychology; R & D; R&D; R01 Mechanism; R01 Program; RPG; Receptors, N-Methylaspartate; Recording of previous events; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Support; Research Training; Researchers; Resources; SCYA7; Schools; Schools, Medical; Science; Science of Chemistry; Science of neurochemistry; Scientist; Secure; Social Sciences; Solid; Structure; Students; Surgical; Surgical Interventions; Surgical Procedure; Training; Training Programs; Training Support; Transcend; Underrepresented Minority; United States National Institutes of Health; Universities; Workshop; abuse of drugs; abused drugs; abuses drugs; addiction; base; bioengineering; bioengineering/biomedical engineering; career; career development; cocaine exposure; college; conference; design; designing; drug of abuse; drugs abused; drugs of abuse; experience; fetal exposure; graduate student; improved; in utero; in utero exposure; interest; intra-uterine environmental exposure; intrauterine environmental exposure; medical schools; neurobiological; neurochemistry; neuronal; pathophysiology; prenatal; programs; research and development; science education; social; structural biology; success; surgery; symposium; unborn; under-represented minority; underserved minority",MIDARP at CCNY,,18055,ZDA1,Special Emphasis Panel,,5,429901,
7761242,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD001691-06,,NCMHD:563199;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,NEW YORK,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,078861598,US,NY,100296574,MOUNT SINAI SCHOOL OF MEDICINE OF NYU,"HOROWITZ, CAROL R;",6728292;,5R24MD001691,09/30/2005,01/31/2013,"0-11 years old; 21+ years old; Address; Adult; Aged 65 and Over; Anniversary; Arm; Back; Bears; Behavior; Body Weight; Body Weight decreased; Child; Child Youth; Children (0-21); Chronic Disease; Chronic Illness; Collaborations; Communities; Community Actions; Community Networks; Consultations; Death Rate; Development; Diabetes Mellitus; Diabetes prevention; Disease; Disorder; Dorsum; Economics; Education; Educational aspects; Educational workshop; Effectiveness; Effectiveness of Interventions; Elderly; Elderly, over 65; Enrollment; Epidemic; Evaluation; Friends; Goals; Hand; Health; High Prevalence; Human, Adult; Human, Child; Intervention; Intervention Strategies; Investigators; Knowledge; Latino; Lead; Learning; Life Style; Lifestyle; Location; Low income; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Methods; Minority; Neighborhoods; New York City; Nutrition; Nutritional Science; Obesity; Over weight; Overweight; Pb element; Phase; Physical activity; Plague; Policies; Prediabetes; Prediabetes syndrome; Prediabetic State; Preparation; Preventive; Preventive Intervention; Programs (PT); Programs [Publication Type]; Publishing; QOL; Quality of life; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Design; Research Personnel; Research Resources; Researchers; Resources; Science of nutrition; Screening procedure; Sight; Site; Sound; Sound - physical agent; Study Type; Testing; Time; TimeLine; Translating; Translatings; Travel; Uninsured; Upper arm; Ursidae; Ursidae Family; Vision; Voice; Walking; Weight; Weight Loss; Weight Reduction; Work; Workshop; Yersinia pestis disease; adiposity; adult human (21+); advanced age; base; body weight loss; children; chronic disease/disorder; chronic disorder; community based participatory research; community organizations; coping; corpulence; corpulency; corpulentia; cost; design; designing; diabetes; diabetic; disease/disorder; dissemination research; effect of intervention; effectiveness trial; efficacy research; elders; enroll; experience; geriatric; health disparities; health disparity; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interventional strategy; language translation; late life; later life; meetings; novel; nutrition; obese; obese people; obese person; obese population; older adult; older person; outreach; peer; prevent; preventing; preventional intervention strategy; primary outcome; programs; randomisation; randomization; randomized controlled study; randomly assigned; recruit; screening; screenings; secondary outcome; senior citizen; skills; social; sound; study design; syndrome x; treatment as usual; wt-loss; youngster",Collaborations for Health Improvement in East Harlem - Project HEED,,1691,ZMD1,Special Emphasis Panel,,6,563199,
7758851,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002757-03,,NCMHD:570775;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,LEXINGTON,UNITED STATES,PSYCHOLOGY,06,939017877,US,KY,405060057,UNIVERSITY OF KENTUCKY,"SCHOENBERG, NANCY E;",8539994;,5R24MD002757,05/22/2008,01/31/2013,"Abstinence; Address; Affect; Cancer Control; Cancer Control Science; Cancer Prevention, Secondary; Cancer Screening for Patients; Cancer of Breast; Cancer of Cervix; Cancer of Lung; Cancer of the Uterine Cervix; Cancers; Cervical; Cervical Cancer; Cervix Cancer; Cessation of smoking; Chronic Disease; Chronic Illness; Collaborations; Colorectal Cancer; Communities; Diet; Diet Modification; Effectiveness of Interventions; Ensure; Evaluation; Event; Fostering; Goals; Health; Health Carnival; Health Fairs; Health Risk Appraisals; Health expo; Health exposition; Incidence; Institution; Intervention; Intervention Strategies; Intervention Studies; Interview; Kentucky; MMG; Malignant Cervical Neoplasm; Malignant Cervical Tumor; Malignant Neoplasm of the Cervix; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Cervix; Malignant Tumor of the Cervix Uteri; Malignant Tumor of the Lung; Malignant Uterine Cervix Neoplasm; Malignant Uterine Cervix Tumor; Malignant neoplasm of breast; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Mammogram; Mammography; Methods; MoAb R24; Modeling; Modifications, Dietary; Monoclonal Antibody R24; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; NCMHD; National Center on Minority Health and Health Disparities; Ohio; Outcome; Pap Test; Pap smear; Papanicolaou Smear; Papanicolaou Test; Participant; Phase; Physical activity; Population; Prevention; Prevention program; Process; Programs (PT); Programs [Publication Type]; Pulmonary Cancer; Pulmonary malignant Neoplasm; R-24 Monoclonal Antibody; R24; Randomized; Regimen; Research; Research Design; Risk Appraisals, Health; Risk Factors; Rural; Rural Health; Screening for Colorectal Cancer; Screening for cancer; Secondary Cancer Prevention; Secondary Prevention; Smears, Cervical; Smoking; Study Type; Testing; Training; Trust; Universities; Vaginal Smears; Work; base; cancer disparity; cancer health disparity; cancer prevention; cancer risk; cease smoking; cervical/vaginal smear; chronic disease/disorder; chronic disorder; colorectal cancer screening; community based participatory research; design; designing; diet and exercise; early cancer detection; early detection of colorectal cancer; effect of intervention; energy balance; health disparities; health disparity; holistic approach; intervention design; interventional strategy; lung cancer; malignancy; malignant breast neoplasm; medically underserved; member; neoplasm/cancer; preference; prevent; preventing; programs; randomisation; randomization; randomly assigned; response; smoking cessation; study design; successful intervention; therapy design; treatment design",Faith Moves Mountains: A CBPR Appalachian Wellness & Cancer Prevention Program,,2757,ZMD1,Special Emphasis Panel,,3,570775,
7766249,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002768-03,,NCMHD:451854;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,SEATTLE,UNITED STATES,,07,075738179,US,WA,98104,"NEIGHBORHOOD HOUSE, INC.","SHARIFY, DENISE TUNG;",8672700;,5R24MD002768,05/22/2008,01/31/2013,"21+ years old; Active Follow-up; Address; Adult; Advocacy; Affect; Area; Arts; Cancers; Cardiovascular Diseases; Collaborations; Color; Communities; Community Health; Community Participation; Community Services; County; Development; Diabetes Mellitus; Economic Income; Economical Income; Effectiveness; Environment; Esthetics; Evaluation; Focus Groups; Goals; Group Interviews; Health; Health Benefit; Health Care Professional; Health Instruction; Health Professional; Health Status; Health Training; Health Tutoring; Health education; Health profession; Healthcare professional; Healthcare worker; Housing; Human, Adult; Immigrant; Impact evaluation; Income; Individual; Intervention; Intervention Strategies; Interviews, Group; Learning; Level of Health; Life; Life Style; Lifestyle; Low income; Malignant Neoplasms; Malignant Tumor; Measures; Mission; Neighborhoods; Obesity; Participation, Community; Perception; Physical activity; Play; Population; Process; Programs (PT); Programs [Publication Type]; Public Health; Public Housing; Refugees; Reporting; Research Resources; Resources; Role; Safety; Services; Social Network; Social support; Walking; Work; adiposity; adult human (21+); base; cancer type; cardiovascular disorder; community based participatory research; corpulence; corpulency; corpulentia; diabetes; ethnic minority; ethnic minority population; fitness; follow-up; health disparities; health disparity; high risk; improved; interventional strategy; malignancy; neoplasm/cancer; obese; obese people; obese person; obese population; obesity prevention; programs; psychosocial; public health medicine (field); public health priorities; social; social capital; social role; social support network; stem",Partnership for Fitness and Healthy Living in Marginalized Communities,,2768,ZMD1,Special Emphasis Panel,,3,451854,
7772354,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002780-03,,NCMHD:576662;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,LAWRENCE,UNITED STATES,OTHER HEALTH PROFESSIONS,03,076248616,US,KS,660457568,UNIVERSITY OF KANSAS LAWRENCE,"FAWCETT, STEPHEN BRUCE;",8254572;,5R24MD002780,06/01/2008,01/31/2013,"21+ years old; Adult; Affect; African American; Afro American; Afroamerican; Black Populations; Black or African American; Cardiovascular Diseases; Cholest-5-en-3-ol (3beta)-; Cholesterol; Chronic Disease; Chronic Illness; Cities; Communities; Community Health; Community Practice; Consumption; Data; Development; Diabetes Mellitus; Disease; Disorder; Documentation; Elements; Evaluation; Feedback; Health; Human, Adult; Intervention; Intervention Strategies; Kansas; Latino; Logic; Methodology, Research; Minority; Mission; Missouri; Modeling; Obesity; Outcome; Physical activity; Policies; Population; Process; Programs (PT); Programs [Publication Type]; Research Methodology; Research Methods; Risk Behaviors; Risk Factors; Risky Behavior; Sampling; Science; Sight; Survey Instrument; Surveys; System; System, LOINC Axis 4; Target Populations; Testing; Universities; Vision; adiposity; adult human (21+); at risk behavior; black American; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; chronic disease/disorder; chronic disorder; community based participatory research; community intervention; corpulence; corpulency; corpulentia; design; designing; diabetes; diabetes risk; disease/disorder; experiment; experimental research; experimental study; fruits and vegetables; health disparities; health disparity; health equity; improved; innovate; innovation; innovative; interventional strategy; member; metropolitan; obese; obese people; obese person; obese population; programs; research study; self reported behavior; working group",Implementing the Health for All Model with Latino Community of Kansas City,,2780,ZMD1,Special Emphasis Panel,,3,576662,
7760977,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002787-03,,NCMHD:568794;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,HATTIESBURG,UNITED STATES,NUTRITION,04,623335775,US,MS,394060001,UNIVERSITY OF SOUTHERN MISSISSIPPI,"YADRICK, KATHLEEN ;",9191297;,5R24MD002787,05/22/2008,01/31/2013,"21+ years old; Address; Adult; African American; Afro American; Afroamerican; American; Arm; Black Populations; Black or African American; Blood Pressure; Blood Pressure, High; Cardiovascular Diseases; Communities; Counseling; Data; Diaries; Diaries (PT); Diaries [Publication Type]; Dietary Intervention; Dimensions; Education; Education for Intervention; Educational Intervention; Educational aspects; Evaluation; Evidence based practice guidelines; Feedback; Food; Health; Human, Adult; Hypertension; Individual; Infrastructure; Instruction Intervention; Intervention; Intervention Strategies; Knowledge; Leadership; Life; Maintenance; Maintenances; Methods; Mississippi; Modeling; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Nutrition Interventions; Nutritional Interventions; Obesity; Outcome; Outcome Measure; Participant; Phase; Phone; Physical activity; Population; Populations at Risk; Prevalence; Process; Process Measure; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Randomized; Research; Research Design; Research Infrastructure; Research Resources; Resources; Social support; Structure; Study Type; Telephone; Testing; Training Intervention; Translational Research; Translational Research Enterprise; Translational Science; Upper arm; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Volunteer Group; Walking; adiposity; adult human (21+); base; black American; cardiovascular disorder; community based participatory research; corpulence; corpulency; corpulentia; design; designing; diaries; evidence based guidelines; evidence based recommendations; group intervention; health disparities; health disparity; hyperpiesia; hyperpiesis; hypertensive disease; improved; instructional intervention; intervention effect; interventional strategy; motivational enhancement therapy; motivational interview; obese; obese people; obese person; obese population; programs; public health medicine (field); randomisation; randomization; randomly assigned; skills; social support network; staff intervention; study design; successful intervention; translation research enterprise; treatment effect; volunteer",A Community Partnership to Reduce Blood Pressure among African American Adults,,2787,ZMD1,Special Emphasis Panel,,3,568794,
7763946,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002803-03,,NCMHD:476609;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,BALTIMORE,UNITED STATES,NONE,07,879941318,US,MD,21251,MORGAN STATE UNIVERSITY,"WAGNER, FERNANDO A;",7745481;,5R24MD002803,06/05/2008,01/31/2013,"21+ years old; Academia; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Accounting; Adopted; Adult; Affect; Americas; Applications Grants; Availability of Health Services; Awareness; Awarenesses; Baltimore; Bears; Behavior; Canada; Cancers; Cardiac Diseases; Cardiac Disorders; Cause of Death; Cessation of life; Cessation of smoking; Characteristics; Collaborations; Color; Communication; Communities; Community Health; Community Health Centers; Consumption; Country; County; Data; Death; Dependence; Development; Disadvantaged; Disease; Disorder; Drops; Drug abuse; Economic Income; Economical Income; Education; Educational Mainstreaming; Educational aspects; Effectiveness; Effectiveness of Interventions; Empirical Research; Ensure; Environment; Evaluation; Evidence based intervention; FLR; Failure (biologic function); Female; Goals; Grant Proposals; Grants, Applications; Habits; Health; Health Services Accessibility; Health Surveys; Heart Diseases; Homelessness; Housing; Human, Adult; IT Systems; Incentives; Income; Individual; Information Systems; Information Technology Systems; Intervention; Intervention Strategies; Intervention Studies; Investigators; Language; Lead; Learning; Life; Low income; Lung diseases; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Manuals; Marketing; Maryland; Mass Media; Medical; Methodology, Research; Methods; Methods and Techniques; Methods, Other; Minority; MoAb R24; Modeling; Monoclonal Antibody R24; Motivation; NCMHD; National Center on Minority Health and Health Disparities; Nicotine Replacement Therapy; Outcome; Participant; Patient Self-Report; Pattern; Pb element; Phase; Play; Pneumonia; Pneumonitis; Policies; Population; Prevention; Principal Investigator; Process; Program Development; Programs (PT); Programs [Publication Type]; Public Health; Publications; Pulmonary Diseases; Pulmonary Disorder; Pulmonary Inflammation; Qualitative Methods; R-24 Monoclonal Antibody; R24; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Design; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Rights; Risk; Role; Satellite Centers; Science of Statistics; Scientific Publication; Self-Report; Series; Services; Sight; Single Parent; Smoke; Smoker; Smoking; Social Marketing; Social Welfare; Solutions; Staging; Statistics; Study Type; Systems, Data; Techniques; Testing; Tobacco; Tobacco Cessation; Tobacco Consumption; Tobacco Use Cessation; Tobacco smoking; Tobacco use; Translating; Translatings; Underemployment; Underserved Population; Universities; Ursidae; Ursidae Family; Vision; West Virginia; Work; abuse of drugs; abuses drugs; access to services; access to treatment; adult human (21+); availability of services; base; behavior change; cease smoking; chronic stroke; community based participatory research; community setting; cost; design; designing; disease/disorder; effect of intervention; effective intervention; experiment; experimental research; experimental study; failure; health care availability; health care service access; health care service availability; health disparities; health disparity; health services availability; healthcare access availability; healthcare service access; healthcare service availability; heart disorder; heavy metal Pb; heavy metal lead; homeless; improved; inattention; inattentiveness; incentive; inducement; informant; innovate; innovation; innovative; insight; instrument; interventional strategy; language translation; low socioeconomic status; lung disorder; male; malignancy; mass information media; member; motivated behavior; multidisciplinary; neoplasm/cancer; nicotine replacement; programs; public education; public health medicine (field); public health relevance; randomized controlled study; recruit; reduce tobacco use; research study; response; smoking cessation; smoking prevalence; social role; standard care; statistics; study design; success; successful intervention; surveillance strategy; tool; treatment strategy; under served population; underemployed; underserved people; unhoused; welfare",CBPR to Reduce Tobacco Smoking among Residents of a Low-Income Urgan Setting,,2803,ZMD1,Special Emphasis Panel,,3,476609,
7770884,R24,MD,5,,02/01/2010,01/31/2011,MD-07-003,5R24MD002807-03,,NCMHD:394506;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,TALLAHASSEE,UNITED STATES,NONE,02,790877419,US,FL,323064166,FLORIDA STATE UNIVERSITY,"RALSTON, PENNY ANN;",9215836;,5R24MD002807,06/03/2008,01/31/2013,"Achievement; Achievement Attainment; Advisory Committees; Affect; African American; Afro American; Afroamerican; American; Apoplexy; Awareness; Awarenesses; Behavior; Black Populations; Black or African American; Blood Coagulation Factor IV; Blood Pressure; Blood Pressure, High; Body Weight; Ca++ element; Calcium; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Church; Clinical; Coagulation Factor IV; Communities; Consumption; Data; Development; Diet Records; Dietary Records; Disease; Disorder; Effectiveness; Elements; Environment; Factor IV; Fats; Fatty acid glycerol esters; Florida; Food; Food Diaries; Frequencies (time pattern); Frequency; Goals; Habits; Health; Health Promotion; Health Status; Hypertension; Intervention; Intervention Strategies; Lead; Learning; Level of Health; Life Style; Lifestyle; Literature; Mediating; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Na element; Organ System, Cardiovascular; Outcome; Pb element; Physical activity; Population; Process; Programs (PT); Programs [Publication Type]; Questionnaires; Research; Risk Factors; Salutogenesis; Sodium; Staging; Stroke; Task Forces; Testing; Time; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; base; behavior change; black American; blood lipid; brain attack; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cerebral vascular accident; circulatory system; disease/disorder; faith-based intervention; fruits and vegetables; heavy metal Pb; heavy metal lead; hyperpiesia; hyperpiesis; hypertensive disease; improved; instrument; interventional strategy; mid life; mid-life; middle age; middle aged; midlife; programs; stroke; sugar",Reducing Cardiovascular Disease Risk in Mid-life and Older African Americans,,2807,ZMD1,Special Emphasis Panel,,3,394506,
7756571,R24,MH,5,,01/01/2010,12/31/2010,PAR-04-015,5R24MH074670-04,,NIMH:474921;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,INDIANAPOLIS,UNITED STATES,PSYCHOLOGY,07,603007902,US,IN,462025167,INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS,"SALYERS, MICHELLE P;",3125111;,5R24MH074670,01/01/2007,12/31/2011,"21+ years old; Address; Adult; Area; Attention; CMHC; Certification; Clinical; Collaborations; Communities; Community Integration; Community Mental Health Centers; Consensus; Consultations; Effectiveness; Emotional well being; Environment; Ethnography; Evidence based practice; Family; Family member; Feels well; Freedom; Funding; Goals; Grant; Hand; Health Care Providers; Health Personnel; Health system; Healthcare Providers; Healthcare worker; Human, Adult; Indiana; Infrastructure; International; Intervention Studies; Investigation; Investigators; Lead; Learning; Liberty; Literature; Measures; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Mental well-being; Methods; Modeling; Models, Organizational; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Normal mental condition; Normal mental state; Normal psyche; Organizational Models; Outcome; PROV; Pb element; Pilot Projects; Prevention; Provider; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychological Well Being; R01 Mechanism; R01 Program; RPG; Randomized; Recovery; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Training; Researchers; Resources; Sense of well-being; Services; Sight; Time; Training; Training Programs; United States National Institute of Mental Health; Universities; Unspecified Mental Disorder; Vision; Well in self; Work; adult human (21+); authority; base; clinical significance; clinically significant; design; designing; ethnographic; evidence base; experience; financial incentive; health care personnel; health care worker; health provider; healthcare personnel; heavy metal Pb; heavy metal lead; improved; infrastructure development; medical personnel; mental illness; pilot study; psychological disorder; psychological wellness; randomisation; randomization; randomly assigned; research to practice; response; self wellness; serious mental illness; severe mental illness; treatment center; treatment program; treatment provider",Recovery Oriented Assertive Community Treatment,,74670,SRSP,Mental Health Services in MH Specialty Settings,,4,474921,
7769526,R24,MH,5,,02/01/2010,01/31/2011,PAR-06-441,5R24MH077192-03,,NIMH:582541;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,SAN FRANCISCO,UNITED STATES,PSYCHIATRY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"AREAN, PATRICIA A.;",1897378;,5R24MH077192,04/01/2008,01/31/2013,"21+ years old; Address; Administrator; Adopted; Adult; African American; Afro American; Afroamerican; Age; Aged 65 and Over; Aging; Black Populations; Black or African American; California; Caring; Charge; Chinese; Chinese People; Client; Clinical; Clinical Management; Clinical Research; Clinical Study; Cognitive; Collaborations; Color; Communities; Computer Software Tools; County; Custom; Data; Data Collection; Depression; Development; Diagnosis; Documentation; Effectiveness; Elderly; Elderly depression; Elderly, over 65; Electronics; Elements; Environment; Ethics Committees, Research; Evaluation; Evidence based intervention; Family; Funding; Goals; Health Care Research; Health Services Evaluation; Health Services Research; Healthcare Research; Heterogeneity, Population; Human, Adult; IRBs; Infrastructure; Institutes; Institutional Review Boards; Intervention; Intervention Strategies; Investigators; Language; Link; Low income; Major Depressive Disorder; Measures; Medical Care Research; Memory Deficit; Memory impairment; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental Patients; Mental disorders; Mental health disorders; Mentally Ill; Mentally Ill Persons; Methods; Minority; Mission; Modeling; Modification; Monitor; Nature; On-Line Systems; Online Systems; Out-patients; Outcome; Outcomes Research; Outpatients; PROV; Performance; Policies; Population Heterogeneity; Preparedness; Procedures; Process; Programs (PT); Programs [Publication Type]; Provider; Psychiatric Diagnosis; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychometric; Psychometrics; Psychotherapy; QOL; Quality of life; R01 Mechanism; R01 Program; RPG; Readiness; Relative; Relative (related person); Research; Research Ethics Committees; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Research, Outcomes; Researchers; San Francisco; Secure; Senescence; Services; Social Service; Social Work; Social work (field); Software Tools; System; System, LOINC Axis 4; Testing; Tools, Software; Training; Training Programs; Underserved Population; Universities; Unspecified Mental Disorder; Validity and Reliability; Work; adult human (21+); advanced age; aged; base; billing data; black American; comparative efficacy; design; designing; disability; diverse populations; elders; evidence base; functional status; geriatric; geriatric depression; geriatric mental health; heterogeneous population; improved; infrastructure development; interest; interventional strategy; late life; late life depression; later life; major depression; member; mental illness; mild cognitive disorder; mild cognitive impairment; mild neurocognitive disorder; older adult; older person; online computer; primary outcome; problem solving therapy; programs; psychological disorder; racial and ethnic; racial/ethnic; randomized trial; response; satisfaction; senescent; senior citizen; services research; success; tool; tool development; treatment as usual; under served population; underserved people; web based",CATALAC: Community-Academic Treatment & Assessment for Low-Income Aged Consumers,,77192,SRNS,Mental Health Services in Non-Specialty Settings,,3,582541,
7764788,R24,RR,5,,02/01/2010,01/31/2011,,5R24RR005090-19,,NCRR:363219;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,DAVIS,UNITED STATES,SOCIAL SCIENCES,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"SMITH, DAVID GLENN;",1862274;,5R24RR005090,09/30/1988,01/31/2012,"Allele Frequency; Animal Model; Animal Models and Related Studies; Animals; Anthropology; Applications Grants; Area; Assay; Bio-Informatics; Bioassay; Bioinformatics; Biologic Assays; Biological Assay; Biomedical Research; Bleeding; Blood Sample; Blood specimen; Breeding; California; Charge; China; Chinese; Chinese People; Client; Collaborations; Competence; Country; Crossbreeding; DNA; DNA, Mitochondrial; Deoxyribonucleic Acid; Distant; Economic Income; Economical Income; Effectiveness; Exclusion; Exhibits; Forensic Medicine; Forensics; Founder Generation; Frequencies (time pattern); Frequency; Functional RNA; Funding; Gene Frequency; Gene variant; Genes; Genetic; Genetic Diversity; Genetic Heterogeneity; Genetic Identity; Genetic Structures; Genetic Variation; Genetic analyses; Genetics, Population; Genome; Genome Mappings; Genotype; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Gills; Grant; Grant Proposals; Grants, Applications; Habitats; Hemorrhage; Human; Human, General; Hybridization, Genetic; Immune; Inbreeding; Income; India; Infrastructure; Institutes; Investigators; Laboratories; Laboratory Research; Letters; Location; Macaca; Macaca mulatta; Macaque; Mainland China; Mammals, Primates; Man (Taxonomy); Man, Modern; Mappings, Genome; Masks; MeSH Descriptors Class 4; Methods; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Minor; Mitochondrial DNA; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Coding; Non-Coding RNA; Nuclear; PROV; Paper; Phylogenetic Analysis; Phylogenetics; Play; Polymorphism Analysis; Polymorphism Detection; Polymorphism, Single Base; Population; Population Genetics; Population Sizes; Primates; Principal Investigator; Probability; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Province; Publications; Reagent; Recommendation; Recovery; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research, Laboratory; Researchers; Review Committee; Rhesus; Rhesus Macaque; Rhesus Monkey; Role; SNP; SNPs; Salaries; Sample Size; Sampling; Scanning; Scientific Publication; Services; Shipping; Ships; Single Nucleotide Polymorphism; Sorting - Cell Movement; Sperm; Spermatozoa; Structure; Study Type; Suggestion; System; System, LOINC Axis 4; TXT; Testing; Text; Time; United States National Institutes of Health; Variation (Genetics); Wages; Writing; X Chromosome; Zoology; allelic frequency; allelic variant; animal colony; autosome; base; blood loss; compare effectiveness; cost; design; designing; evidence base; father role; forest; founder population; genetic analysis; geographic site; member; microchip; model organism; mtDNA; neglect; pathogen; programs; role of father; social role; sorting; sperm cell; study design; tool; web site; zoosperm",Genetic Management of Animal Colonies,,5090,ZRR1,Special Emphasis Panel,,19,363219,
7756686,R24,RR,5,,02/01/2010,01/31/2011,,5R24RR014085-08,,NCRR:452925;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SEATTLE,UNITED STATES,,07,076647908,US,WA,981012795,BENAROYA RESEARCH INST AT VIRGINIA MASON,"AMEMIYA, CHRIS TSUYOSHI;",1892841;,5R24RR014085,04/15/2000,01/31/2013,"1-Ethyl-1-nitrosourea; Address; Animal Model; Animal Models and Related Studies; Applications Grants; Area; Artificial Chromosomes; Base Pairing; Biological Models; Biology; Biomedical Research; Biotechnology; Birth Defects; Brachydanio rerio; Candidate Disease Gene; Candidate Gene; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Segregation; Cell Separation; Cell Separation Technology; CellLine; Cells; Chromosomes, Artificial; Cloning; Communities; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; DNA Molecular Biology; DNA Sequence Rearrangement; Danio rerio; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Disease; Disorder; Drosophila; Drosophila genus; ENU; Embryo; Embryonic; Environment; Equipment; Ethylnitrosourea; Fingerprint; Fruit Fly, Drosophila; Gene Transfer Techniques; Generations; Genes; Genome; Genomics; Goals; Grant; Grant Proposals; Grants, Applications; Hand; Human; Human Resources; Human, General; Immunity; Immunologic, Immunochemical; Immunologics; Individual; Infrastructure; Insertional Mutagenesis; Institutes; Instruction; Investigation; Investigators; Label; Laboratories; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Letters; Libraries; Man (Taxonomy); Man, Modern; Manpower; Maps; Methods; Microinjections; Mission; MoAb R24; Model System; Modeling; Models, Biologic; Molecular Biology; Molecular Genetic Abnormality; Monoclonal Antibody R24; Mutagenesis, Insertional; N-Ethyl-N-nitrosourea; NCRR; NIH; National Center for Research Resources; National Institutes of Health; National Institutes of Health (U.S.); Nitrosoethylurea; Paper; Phenotype; Plasmids; Population; Programs (PT); Programs [Publication Type]; R-24 Monoclonal Antibody; R01 Mechanism; R01 Program; R24; RPG; Reagent; Rearrangement; Reporter; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Role; Running; Science; Screening procedure; Series; Services; Site; Solutions; Specialist; System; System, LOINC Axis 4; T-Cells; T-Lymphocyte; Tars; Technology; Thymus-Dependent Lymphocytes; Training; Training Programs; Transgenesis; Transgenic Animals; Transgenic Organisms; United States National Institutes of Health; Urea, N-ethyl-N-nitroso-; Veterinarians; Work; Zebra Danio; Zebra Fish; Zebrafish; analytical tool; base; case-based; cell sorting; clinical data repository; clinical data warehouse; college; cultured cell line; data repository; density; disease/disorder; experiment; experimental research; experimental study; fruit fly; human disease; improved; interest; lectures; model organism; mutant; personnel; positional cloning; programs; recombinase; relational database; research study; reverse genetics; scaffold; scaffolding; screening; screenings; social role; success; teacher; thymus derived lymphocyte; transgenic; vector; zebrafish genome",Genomics Resources and Infrastucture for the Zebrafish,,14085,RIRG,National Center for Research Resources Initial Review Group,,8,452925,
7743803,R25,DE,5,,02/01/2010,01/31/2011,PAR-06-506,5R25DE018663-03,,NIDCR:162000;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,SAN ANTONIO,UNITED STATES,DENTISTRY,20,800772162,US,TX,78229,UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT,"RUGH, JOHN D;",1898991;,5R25DE018663,02/04/2008,01/31/2012,"Animal Welfare; Attitude; Basic Behavioral Science; Bibliography; Biomedical Research; Clinical; Clinical Research; Clinical Study; Collaborations; Country; Curriculum; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dental; Dental Education; Dental Faculty; Dental Research; Dental Schools; Dental Students; Dentistry; Dentists; Development; Doctor of Philosophy; Ecological impact; Education; Education, Dental; Educational Curriculum; Educational aspects; Educational process of instructing; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evidence based practice; Faculty; Faculty, Dental; Funding; General Population; General Public; Goals; Hand; Health Sciences; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Instruction; International; Investigation; Knowledge; Libraries; Literature; Methodology, Research; NIDR; Names; National Institute of Dental Research; National Institute of Dental and Craniofacial Research; Oral health; Participant; Patient Care; Patient Care Delivery; Ph.D.; PhD; Preparation; Principal Investigator; Private Practice; Program Development; Programs (PT); Programs [Publication Type]; Research; Research Ethics Committees; Research Methodology; Research Methods; Research Resources; Research Training; Residencies; Resources; Role; Schools; Schools, Dental; Science; Students; Students, Dental; Supervision; Teaching; Technology; Testing; Thinking; Thinking, function; Time; Training; Training Programs; Translating; Translatings; Vertebrate Animals; Vertebrates; Writing; abstracting; bench bed side; bench bedside; bench to bed side; bench to bedside; career; clinical data repository; clinical data warehouse; clinical practice; clinical relevance; clinically relevant; data repository; dental health; dentistry education; evidence base; expiration; human subject; innovate; innovation; innovative; interest; language translation; post-doctoral training; postdoctoral training; pre-doc; pre-doctoral; predoc; predoctoral; programs; relational database; science education; social role; tool; vertebrata","Bridging Oral Health Science, Education & Practice:  A CATs Initiative",,18663,ZDE1,Special Emphasis Panel,,3,162000,
7779452,R25,DK,5,,02/01/2010,01/31/2011,PAR-06-554,5R25DK082376-02,,NIDDK:108000;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,NUTRITION,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"BRUNENGRABER, HENRI ;",1872032;,5R25DK082376,03/01/2009,01/31/2014,"Abnormal Assessment of Metabolism; Advisory Committees; Animals; Bio-Informatics; Bioinformatics; Development; Educational process of instructing; Educational workshop; Faculty; Goals; Hand; Human; Human, General; Intermediary Metabolism; Investigation; Investigators; Isotopes; Laboratories; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Metabolic; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Methods and Techniques; Methods, Other; Mice; Murine; Mus; NIDDK; NIH; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Digestive Diseases and Kidney Disorders; National Institutes of Health; National Institutes of Health (U.S.); Phenotype; Proteomics; Research; Research Personnel; Research Training; Researchers; Running; Schools, Medical; Scientist; Series; Task Forces; Teaching; Techniques; Technology; Testing; Texas; Time; Training; Training Activity; United States; United States National Institutes of Health; Universities; Washington; Workshop; graduate student; literacy; measurement of metabolism; medical schools; member; metabolic abnormality assessment; metabolomics",Training in isotopic techniques for metabolic research,,82376,DDK,Diabetes and Digestive and Kidney Diseases Special Grants Review Committee,,2,108000,
7758270,R25,GM,5,,02/01/2010,01/31/2011,PAR-05-132,5R25GM055052-12,,NIGMS:495533;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,CHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"WEISS, RICHARD LOUIS;",1862924;,5R25GM055052,09/30/1996,01/31/2011,"Academic achievement; African American; Afro American; Afroamerican; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; Baccalaureate Degree; Bachelor's Degree; Biomedical Research; Black Populations; Black or African American; CCL7; CCL7 gene; California; Career Counseling; Communities; Complement; Complement Proteins; Counseling; Development; Doctor of Philosophy; Education; Educational aspects; Educational workshop; Ethnic Origin; Ethnic group; Ethnicity; Ethnicity aspects; Face; Faculty; Financial Support; Future Generations; Generations, Future; Goals; Hispanic Americans; History; Investigators; Journals; Latino; Leadership; Life; Literature; MARC; MCP-3; MCP3; Magazine; Measurable; Mentors; Methods and Techniques; Methods, Other; Minority; NC28; NCI Scholars Program; NIH; National Institutes of Health; National Institutes of Health (U.S.); Native Alaskan; Native Americans; Occupational Guidance; Pacific Island Americans; Pacific Islander; Pacific Islander American; Participant; Ph.D.; PhD; Play; Position; Positioning Attribute; Program Development; Programs (PT); Programs [Publication Type]; Puerto Rican; R01 Mechanism; R01 Program; RPG; Reading; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Support; Researchers; Role; SCYA7; Scholars Program; Schools; Science; Science Enrichment; Scientist; Spanish Americans; Students; Sum; System; System, LOINC Axis 4; Techniques; Training; Training Programs; Underrepresented Minority; United States National Institutes of Health; Universities; Vocational Guidance; Work; Workshop; black American; career; cohort; experience; facial; graduate student; interest; meetings; physical science; programs; recruit; role model; skills; social role; success; under-represented minority; underserved minority",Maximizing  Student Diversity Program,,55052,ZGM1,Special Emphasis Panel,,12,495533,
7763825,R25,GM,5,,02/01/2010,01/31/2011,PAR-05-132,5R25GM056806-12,,NIGMS:346879;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOZEMAN,UNITED STATES,OTHER HEALTH PROFESSIONS,00,625447982,US,MT,59717,MONTANA STATE UNIVERSITY (BOZEMAN),"CAMPER, ANNE K;",3141889;,5R25GM056806,02/01/1998,01/31/2011,"Admission; Admission activity; American Indian; American Indians; Biomedical Research; Communities; Discipline; Enrollment; Faculty; Goals; Health; Indians, American; Instruction; Mentors; Montana; Oral; Posters; Posters [Publication Type]; Programs (PT); Programs [Publication Type]; Public Health; Research; Research Resources; Resources; Sampling; Schools; Students; Testing; Universities; Work; career; college student; conference; enroll; experience; graduate student; health disparities; health disparity; high school; improved; interest; posters; programs; public health medicine (field); skills; success; symposium; tribal college; tribal university; university student",Montana Initiative for Maximizing Student Diversity,,56806,ZGM1,Special Emphasis Panel,,12,346879,
7762754,R25,GM,5,,02/01/2010,01/31/2011,PAR-06-548,5R25GM060926-07,,NIGMS:214371;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW ORLEANS,UNITED STATES,CHEMISTRY,02,020857876,US,LA,701251098,XAVIER UNIVERSITY OF LOUISIANA,"KLEIN STEVENS, CHERYL L;",7822332;,5R25GM060926,04/01/2000,01/31/2012,"Abscission; Achievement; Achievement Attainment; African American; Afro American; Afroamerican; Animal Welfare; Benchmarking; Best Practice Analysis; Bibliography; Biochemical; Biology; Biomedical Research; Black Populations; Black or African American; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Competence; Country; Critiques; Data; Development; Discipline; EXTMR; Ecological impact; Editorial Comment; Editorial Comment (PT); Educational process of instructing; Effectiveness; Effectiveness of Interventions; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Excision; Extirpation; Extramural; Extramural Activities; Faculty; Fostering; Funding; Goals; Guidelines; Hand; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Instruction; International; Knowledge; Laboratory Research; Learning; Libraries; Measurable; Measures; Mentors; Methods and Techniques; Methods, Other; National Academy of Sciences; National Academy of Sciences (U.S.); Oral; Outcome; Participant; Plant Embryos; Posters; Posters [Publication Type]; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Published Comment; R01 Mechanism; R01 Program; RPG; Recommendation; Relative; Relative (related person); Removal; Reports, Progress; Research; Research Ethics Committees; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research, Laboratory; Resources; Schools; Science; Seeds; Series; Students; Surgical Removal; System; System, LOINC Axis 4; Teaching; Techniques; Technology; Testing; Thinking; Thinking, function; Time; Training; United States National Academy of Sciences; Universities; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; Zygotes, Plant; abstracting; base; black American; career; design; designing; effect of intervention; experience; expiration; human subject; interest; meetings; posters; programs; resection; seed; skills; technical writing; vertebrata",MBRS RISE Program at Xavier University,,60926,MPRC,Minority Programs Review Committee,,7,214371,
7769882,R25,GM,5,,02/01/2010,01/31/2011,,5R25GM062459-08,,NIGMS:532647;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NASHVILLE,UNITED STATES,PHYSIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"CHALKLEY, G. ROGER;",2411617;,5R25GM062459,10/01/2000,01/31/2011,"Academic Medical Centers; Academy; Address; Admission; Admission activity; Advertising; African; African American; Afro American; Afroamerican; American; Americas; Area; Articulation; Arts; Asian Americans; Asians; Award; Awareness; Awarenesses; Baccalaureate Degree; Bachelor's Degree; Biochemistry; Biomedical Research; Biophysics; Black Populations; Black or African American; Businesses; Caliber; California; Caucasian; Caucasian Race; Caucasians; Caucasoid; Caucasoid Race; Cellular biology; Charge; Chemistry, Biological; Clinic; Country; Data; Dentistry; Dependence; Development; Diameter; Disadvantaged; Discipline; Discipline of Nursing; Doctor of Philosophy; Doctor's Degree; Doctorate Degree; Education; Educational aspects; Educational process of instructing; Engineering; Engineerings; Enrollment; Environment; Ethnic Origin; Ethnic and Racial Minorities; Ethnicity; Ethnicity aspects; Faculty; Family; Fostering; Funding; Graduate Education; Grant; HBCUs; HOSP; Health Care Professional; Health Professional; Health Sciences; Health profession; Healthcare professional; Healthcare worker; Heart; Hispanic Americans; Hispanic Populations; Hispanics; Hispanics or Latinos; Historically Black Colleges; Historically Black Colleges and Universities; Historically Black Institution; History; Hospitals; Hospitals, Pediatric; Hospitals, University; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Institutes; Institution; Instruction; International; Investments; Joints; Laboratories; Latino Population; Laws; Leadership; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Left; Life; Light; Literature; Los Angeles; Medical; Medical Research; Medical center; Medicine; Mentors; Michigan; Microbiology; Minor; Minority; Minority Groups; Mission; Muslim; Muslim population group; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurosciences; New York; Nursing; Nursing Field; Nursing Profession; Occidental; Pediatric Hospitals; Performance; Ph.D.; PhD; Pharmacology; Phase; Photoradiation; Physiology; Play; Position; Positioning Attribute; Principal Investigator; Programs (PT); Programs [Publication Type]; Progress Reports; Race; Racial Group; Recording of previous events; Recruitment Activity; Reports, Progress; Research; Research Resources; Research, Medical; Resources; Rest; Role; Saint Jude Children's Cancer Center; Saint Jude Children's Research Hospital; Scholarship; Schools; Schools, Medical; Science; Science of Medicine; Science of Microbiology; Scientist; Series; Spanish Americans; Spanish Origin; St. Jude; St. Jude Children's Cancer Center; St. Jude Children's Research Hospital; St.Jude Children's Cancer Center; St.Jude Children's Research Hospital; Stocks, Racial; Stress; Structure; Students; Teaching; Tennessee; Texas; Time; Training; Training and Education; Trustees; Underrepresented Minority; United States; United States National Institutes of Health; Universities; University Hospitals; University Medical Centers; Visit; Work; base; biomedical scientist; black American; career; cell biology; college; college student; design; designing; enroll; experience; experiment; experimental research; experimental study; graduate student; hispanic community; improved; interest; lectures; medical schools; molecular pathology; oriental; post-doctoral training; postdoctoral training; profession allied to medicine; programs; prospective; recruit; research study; science education; social role; under-represented minority; underserved minority; university student; white race",Initiative for Maximizing Student Diversity,,62459,ZGM1,Special Emphasis Panel,,8,532647,
7766944,R25,GM,5,,02/01/2010,01/31/2011,PAR-07-432,5R25GM064133-07,,NIGMS:288425;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ROCHESTER,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"LORD, EDITH M.;",1871391;,5R25GM064133,09/01/2001,01/31/2013,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Area; Arthritis; Award; Bacterial/Viral/Mycotic Disease Immunology; Cancers; Cardiovascular Diseases; Clinical; Collaborations; Communication; Communities; Credentialing; Diabetes Mellitus; Doctor of Philosophy; EXTMR; Education; Educational aspects; Enrollment; Environment; Ethnic and Racial Minorities; Extramural; Extramural Activities; Faculty; Foundations; Funding; Future; Goals; HIV; HTLV-III; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Individual; Infectious Disease Immunology; Institutes; Institution; Instruction; LAV-HTLV-III; Laboratories; Laboratory Technicians; Learning; Lung diseases; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Mentors; Microbiology; Minority; Minority Groups; Participant; Ph.D.; PhD; Preparation; Preparedness; Process; Programs (PT); Programs [Publication Type]; Pulmonary Diseases; Pulmonary Disorder; R01 Mechanism; R01 Program; RPG; Readiness; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Science of Microbiology; Science of Virology; Scientist; Social Network; Students; Supervision; Technicians, Laboratory; Technology; Time; Training; Training Programs; Training and Education; Translational Research; Translational Research Enterprise; Translational Science; Underrepresented Minority; Universities; Virology; Virus-HIV; Work; arthritic; base; cardiovascular disorder; career; conference; design; designing; diabetes; enroll; experience; health disparities; health disparity; interest; lung disorder; malignancy; medically disadvantaged; medically disadvantaged population; medically underserved group; medically underserved population; meetings; member; minority trainee; neoplasm/cancer; peer; pre-doc; pre-doctoral; predoc; predoctoral; programs; skills; symposium; translation research enterprise; under-represented minority; underserved minority; virology",Resource in Education in Microbiology and Immunology,,64133,MPRC,Minority Programs Review Committee,,7,288425,
7777821,R25,GM,5,,02/01/2010,01/31/2011,PAR-07-432,5R25GM066534-07,,NIGMS:276635;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BLACKSBURG,UNITED STATES,VETERINARY SCIENCES,09,003137015,US,VA,24060,VIRGINIA POLYTECHNIC INST AND ST UNIV,"SMITH, EDWARD J;",2076600;,5R25GM066534,09/01/2002,01/31/2013,"Admission; Admission activity; Agriculture; Authorship; Awareness; Awarenesses; Behavioral Sciences; Biologic Sciences; Biological Sciences; Biomedical Research; Climate; Commit; Development; Discipline; Doctor of Philosophy; Education; Educational aspects; Educational process of instructing; Educational workshop; Enrollment; Ensure; Environment; Faculty; Goals; Graduate Education; HBCUs; Historically Black Colleges; Historically Black Colleges and Universities; Historically Black Institution; Hour; Institution; Intervention; Intervention Strategies; Interview; Life Sciences; Mentors; Meteorological Climate; Minority; NCI Scholars Program; NIGMS; National Human Genome Research Institute; National Institute of General Medical Sciences; Outcome; Pathway interactions; Peer Review; Ph.D.; PhD; Principal Investigator; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RPG; Recruitment Activity; Research; Research Activity; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Scholars Program; Schools; Science; Scientist; Series; Social Network; Students; Teaching; Texas; Time; Training; Training Programs; Underrepresented Minority; Universities; Virginia; Woman; Workshop; agricultural; career; climatic; cohort; college; conference; enroll; experience; graduate student; improved; interventional strategy; meetings; member; outreach; pathway; programs; recruit; social; success; symposium; under-represented minority; underserved minority",Virginia Tech Post-baccaluareate Research and Education Program,,66534,MPRC,Minority Programs Review Committee,,7,276635,
7771715,R25,GM,5,,02/01/2010,01/31/2011,PAR-06-548,5R25GM082808-02,,NIGMS:406338;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,ELIZABETH CITY,UNITED STATES,OTHER BASIC SCIENCES,01,066024357,US,NC,27909,ELIZABETH CITY STATE UNIVERSITY,"GWEBU, EPHRAIM TOBELA;",8375543;,5R25GM082808,02/18/2009,01/31/2013,"Achievement; Achievement Attainment; Admission; Admission activity; African American; Afro American; Afroamerican; American; Attitude; Authorship; Awareness; Awarenesses; Behavioral Sciences; Biologic Sciences; Biological Sciences; Biology; Biomedical Research; Black Populations; Black or African American; Censuses; Chemistry; Cities; Competence; County; Credentialing; Curriculum; Discipline; Doctor of Philosophy; Economic Income; Economical Income; Education; Educational Curriculum; Educational aspects; Educational workshop; Enrollment; Ensure; Examination, Graduate Records; Faculty; Family; Funding; Generations; Goals; Graduate Records Examination; Income; Institution; Instruction; Investigators; Journals; Laboratories; Leadership; Life Sciences; Magazine; Mathematics; Measurable; Measures; Mentorship; Minority; Mission; Motivation; North Carolina; Outcome; Paper; Participant; Ph.D.; PhD; Physics; Population; Poverty; Preceptorship; Preparation; Principal Investigator; Programs (PT); Programs [Publication Type]; Psychology; Publications; Publishing; Qualifying; Recruitment Activity; Research; Research Personnel; Research Training; Researchers; Rest; Role; Rural; Rural Community; Schools; Science; Science of Chemistry; Science of Statistics; Scientific Publication; Scientist; Series; Statistics; Students; Talents; Training; Universities; Visit; Work; Workshop; black American; career; college; college student; conference; design; designing; enroll; graduate student; interest; meetings; physical science; programs; recruit; role model; skills; social role; statistics; success; symposium; university student",Elizabeth City State University Support Program for Academic and Research Enhance,,82808,MPRC,Minority Programs Review Committee,,2,406338,
7767700,R25,GM,5,,02/01/2010,01/31/2011,PAR-06-553,5R25GM083247-02,,NIGMS:443674;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LITTLE ROCK,UNITED STATES,PEDIATRICS,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"THOMAS, BILLY R;",1948041;,5R25GM083247,02/13/2009,01/31/2013,"Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acute; Address; Advisory Committees; African American; Afro American; Afroamerican; Age; American Indian; American Indians; Area; Arkansas; Availability of Health Services; Award; Awareness; Awarenesses; Baccalaureate Degree; Bachelor's Degree; Basic Research; Basic Science; Behavioral Research; Biochemistry; Biologic Sciences; Biological; Biological Sciences; Biomedical Research; Biophysics; Black Populations; Black or African American; Care, Health; Chemistry, Biological; Commit; DNA Molecular Biology; Data; Development; Doctor of Philosophy; Education; Education, Medical; Educational aspects; Educational process of instructing; Engineering; Engineerings; Enrollment; Ethnic and Racial Minorities; Face; Faculty; Fellowship; Goals; Graduate Education; Grant; Health; Health Occupations; Health Professions; Health Services Accessibility; Healthcare; Hispanic Americans; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Improve Access; Indians, American; Individual; Institution; Investigators; Laboratories; Lead; Learning; Life; Life Sciences; Master's Degree; Medical; Medical Education; Mentors; Mentorship; Methods; Microbiology; Minority; Minority Groups; Molecular Biology; Monitor; Non-Hispanic; Not Hispanic or Latino; Outcome; Pb element; Ph.D.; PhD; Pharmacology; Physiology; Posters; Posters [Publication Type]; Poverty; Programs (PT); Programs [Publication Type]; Public Health; R01 Mechanism; R01 Program; RPG; Recruitment Activity; Reporting; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Role; Rural; Salaries; Schools; Science; Science of Microbiology; Scientist; Series; Services; Solutions; Spanish Americans; Students; Task Forces; Teaching; Teaching Method; Time; Time Management; Toxicology; Underinsured; Underrepresented Minority; Underserved Population; Uninsured; Universities; Wages; access to services; access to treatment; availability of services; base; black American; college; design; designing; developmental neurobiology; enroll; facial; field study; graduate student; health care availability; health care service access; health care service availability; health science profession; health services availability; healthcare access availability; healthcare service access; healthcare service availability; heavy metal Pb; heavy metal lead; improved; member; posters; programs; public health medicine (field); public health relevance; public health research; recruit; role model; skills; social role; success; under served population; under-represented minority; underserved minority; underserved people",The University of Arkansas for Medical Sciences Initiative for Maximizing Student," IMSD Project Narrative Arkansas is primarily a rural state with a growing number of individuals living at or below the poverty level with limited access to health care (uninsured or underinsured). The state's poor, many of whom are members of minority groups, face health care disparities that can be reduced through health care workforce diversity. Diversity among biomedical sciences students and faculty, which the proposed initiatives will help achieve, is indispensable and will result in improved quality of medical education, improved access to health care for underserved populations, and accelerated advances in medical and public health research, resulting in a reduction in health care disparities and improved public health.",83247,MPRC,Minority Programs Review Committee,,2,443674,
7749994,R25,NS,5,,02/01/2010,01/31/2011,,5R25NS054767-05,,NINDS:57101;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,WASHINGTON,UNITED STATES,,00,126528942,US,DC,20005,SOCIETY FOR NEUROSCIENCE,"KRIEGSTEIN, ARNOLD ;",1894999;,5R25NS054767,05/01/2006,01/31/2011,"Addiction, Drug; Advisory Committees; Affective Disorders; Apoplexy; Applications Grants; Area; Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Causality; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chemical Dependence; Clinical; Clinical Research; Clinical Study; Covering disease; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dependence, Drug; Dimensions; Disease; Disorder; Dourine; Dourines; Drug Addiction; Drug Dependency; Educational process of instructing; Educational workshop; Encephalon; Encephalons; Enrollment; Epilepsy; Epileptic Seizures; Epileptics; Etiology; Faculty; Gilles de la Tourette syndrome; Gilles de la Tourette's Disease; Goals; Grant Proposals; Grants, Applications; Guinon's disease; Human; Human, General; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Infection; Investigators; Laboratories; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Link; MS (Multiple Sclerosis); Mal de coit; Man (Taxonomy); Man, Modern; Molecular; Mood Disorders; Multiple Sclerosis; Muscular Dystrophies; Myodystrophica; Myodystrophy; NRVS-SYS; Nervous System; Nervous System Diseases; Nervous System, Brain; Nervous system structure; Neurobiology; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Body System; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurologic Disorders; Neurologic Organ System; Neurological Disorders; Neuromuscular Diseases; Neurophysiology - biologic function; Neurosciences; Obsessive-Compulsive Disorder; Obsessive-Compulsive Neurosis; Organizations, Professional; Pain; Painful; Participant; Pathogenesis; Patients; Prion Disease Pathway; Prion Diseases; Prion Protein Diseases; Prion-Induced Disorder; Professional Organizations; Progressive Chorea, Hereditary, Chronic (Huntington); Research; Research Personnel; Researchers; Rewards; Running; Sampling; Scientist; Sclerosis, Disseminated; Seizure Disorder; Side; Societies; Spongiform Encephalopathies, Transmissible; Stroke; Students; Task Forces; Teaching; Tic Disorder, Combined Vocal and Multiple Motor; Tourette Syndrome; Tourette's; Tourette's Disease; Tourette's Disorder; Tourette's Syndrome; Training; Transmissible Dementias; Vascular Accident, Brain; Work; Workshop; brain attack; cerebral vascular accident; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; enroll; epilepsia; epileptiform; epileptogenic; excitotoxicity; experience; graduate student; insular sclerosis; interest; lectures; maladie des tics; meetings; myoneural disorder; nervous system disorder; neural function; neurobiological; neurodegenerative illness; neurological disease; neuromuscular disorder; spongiform degeneration; spongiform encephalopathy; stroke; tic de Guinon; tumors in the brain",Neurobiology of Disease -- Teaching Workshop,,54767,ZNS1,Special Emphasis Panel,,5,57101,
7761692,R25,RR,5,,02/01/2010,01/31/2011,PAR-06-549,5R25RR024280-03,,NCRR:268000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,01,077469567,US,ME,04103,UNIVERSITY OF SOUTHERN MAINE,"DUBOISE, SAMUEL MONROE;",6197250;,5R25RR024280,02/01/2008,01/31/2013,Collaborations; Curriculum; Disease; Disorder; Educational Curriculum; Electron Microscope; Faculty; Health; Laboratories; Maine; Medical; Microscopy; Names; Participant; Phase; Principal Investigator; Production; Programs (PT); Programs [Publication Type]; Research; Research Resources; Resources; Science; Science of Virology; Sensory; Space Explorations; Students; Transmission; Virology; Visual; Visual Perception; digital; disease/disorder; nano; outreach; programs; teacher; tomography; transmission process; virology,Micro-and Nano-space Explorations of Health and Disease,,24280,ZRR1,Special Emphasis Panel,,3,268000,
7760679,R33,CA,5,,02/01/2010,01/31/2011,CA-07-005,5R33CA126191-04,,NCI:657451;,2010,NATIONAL CANCER INSTITUTE,,RICHLAND,UNITED STATES,,04,032987476,US,WA,99352,BATTELLE PACIFIC NORTHWEST LABORATORIES,"SMITH, RICHARD D;",8084555;,5R33CA126191,09/28/2006,01/31/2011,"Address; Affinity; Antibodies; Assay; Bioassay; Biologic Assays; Biological Assay; Blood Plasma; Cancer, Oncology; Cancers; Cell Communication and Signaling; Cell Signaling; Complex; Coupled; Data; Data Quality; Detection; Development; ESI; Electrospray Ionization; Evaluation; Gases; Human; Human, General; Informatics; Intracellular Communication and Signaling; Investigators; Ions; Liquid Chromatography; Liquid substance; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measurement; Operation; Operative Procedures; Operative Surgical Procedures; Peptides; Performance; Phase; Photometry/Spectrum Analysis, Mass; Plague; Plasma; Plasma Proteins; Play; Production; Programs (PT); Programs [Publication Type]; Proteins; Proteome; Proteomics; Quality, Data; Reagent; Reproducibility; Research Personnel; Researchers; Resolution; Reticuloendothelial System, Serum, Plasma; Role; Running; Sampling; Sensitivity and Specificity; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Source; Specificity; Spectrometry; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Staging; Surgical; Surgical Interventions; Surgical Procedure; Time; Validation; Yersinia pestis disease; base; biological signal transduction; biomarker; candidate validation; capillary liquid chromatography; clinical applicability; clinical application; clinical relevance; clinically relevant; d-Numb; fluid; gene product; improved; instrument; ion mobility; ionization; liquid; malignancy; nano-electrospray; nanoelectrospray; neoplasm/cancer; novel; numb protein; oncology; pre-clinical; preclinical; programs; prototype; social role; surgery; tool; tumor","A Proteomics Platform for Quantitative, Ultra-High Throughput, and Ultra-Sensitiv",,126191,ZCA1,Special Emphasis Panel,,4,657451,
7764646,R33,DC,5,,02/01/2010,01/31/2011,DC-07-002,5R33DC008630-04,,NIDCD:651420;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,PHILADELPHIA,UNITED STATES,,02,073757627,US,PA,191044318,CHILDREN'S HOSPITAL OF PHILADELPHIA,"CRENSHAW, E BRYAN;",1889270;,5R33DC008630,01/01/2007,01/31/2012,"0-11 years old; Address; Area; Authorization; Authorization documentation; Biomedical Computing; Budgets; Care, Health; Cell Line; Cell Lines, Strains; CellLine; Characteristics; Child; Child Youth; Childhood; Children (0-21); Cities; Clinic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Controlled Vocabulary; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, Genetic; Dataset; Development; Disclosure; Effectiveness; Enrollment; Ensure; Environmental Factor; Environmental Risk Factor; Evaluation; Face; Family; Genetic; Genetic Data Banks; Genetic Data Bases; Genetic Databanks; Genetic Databases; Genetic Information Databases; Genetic Materials; Genetics, Other; Genotype; Grant; Guidelines; Healthcare; Hearing; Hearing Loss; Hospitals, Pediatric; Human Resources; Human Subject Research; Human, Child; Hypoacuses; Hypoacusis; Individual; Information Disclosure; Infrastructure; Institution; Instruction; Investigation; Investigators; Last Name; Letters; Literature; Manpower; Manuscripts; Maps; Materials, Genetic; Medical; Medical Specialities; Methods; Minority; Modeling; Monitor; Names; Ontology; Other Genetics; Outcome; Patients; Pediatric Hospitals; Permission; Phase; Philadelphia; Policies; Policy Research; Position; Positioning Attribute; Principal Investigator; Printing; Procedures; Process; Programs (PT); Programs [Publication Type]; Public Health; Publications; R01 Mechanism; R01 Program; RPG; Research; Research Design; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resource Sharing; Resources; Role; Safety; Scientific Publication; Screening procedure; Security; Specialties, Medical; Specialty; Structure; Study Type; Terminology; Testing; Therapeutic Intervention; Time; United States; Vertebrate Animals; Vertebrates; Vocabulary, Controlled; Woman; base; biomedical computation; children; clinical applicability; clinical application; clinical data repository; clinical data warehouse; clinical investigation; cohort; computer infrastructure; computing resources; cultured cell line; data modeling; data repository; early onset; enroll; environmental risk; experiment; experimental research; experimental study; facial; genetic resource; hESC; hearing impairment; hearing perception; high risk; human ES cell; human ESC; human embryonic stem cell; human subject protection; interest; intervention therapy; literature survey; medical specialties; meetings; patient centered; patient oriented; pediatric; performance site; personnel; programs; public health medicine (field); quality assurance; relational database; repository; research study; screening; screenings; social role; sound perception; study design; vertebrata; web based interface; youngster",Audiological and Genetic Resource for Pediatric Hearing Research,,8630,ZDC1,Special Emphasis Panel,,4,651420,
7743371,R34,MH,5,,12/01/2009,11/30/2010,PAR-06-248,5R34MH076966-02,,NIMH:237643;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,EUGENE,UNITED STATES,,04,053615423,US,OR,97403,OREGON RESEARCH INSTITUTE,"SHEEBER, LISA B;",1905492;,5R34MH076966,12/01/2008,11/30/2011,"0-11 years old; 12-20 years old; Accounting; Address; Adherence; Adherence (attribute); Administrator; Adolescence; Adolescent; Adolescent Development; Adolescent Youth; Adopted; Adoption; Affective; After Care; After-Treatment; Aftercare; Age; Behavioral; CMHC; Child; Child Youth; Children (0-21); Clinical; Clinical Trials; Clinical Trials, Unspecified; Clupeidae; Cognitive; Collaborations; Communities; Community Mental Health Centers; Conflict; Conflict (Psychology); Data; Depressed mood; Depression; Depressive disorder; Development; Diamond; Disease; Disorder; Effectiveness of Interventions; Emotional Depression; Emotions; Empirical Research; Evaluation; Experimental Designs; Family; Family Process; Family Relations; Family Relationship; Family Therapy; Family psychotherapy; Goals; Grant; Human, Child; Intervention; Intervention Strategies; Investigators; Laboratories; Left; Literature; Maintenance; Maintenances; Measures; Mediating; Mental Depression; Mental Health; Mental Hygiene; Modeling; Motivation; Neurosis, Depressive; Parenting; Parenting behavior; Parents; Phase; Population; Population Intervention; Position; Positioning Attribute; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychological Health; Psychopathology; Public Health; Publishing; Research; Research Personnel; Research Resources; Researchers; Resources; Scientist; Services; Socialization; Socializations; Staging; Symptoms; Symptoms of depression; Testing; Therapeutic; Time; Treatment Effectiveness; Vulnerable Populations; Work; Youth; Youth 10-21; abnormal psychology; adolescence (12-20); base; children; clinical investigation; clinical practice; community setting; control trial; depressed; depressive; depressive symptoms; design; designing; disease/disorder; effect of intervention; effective intervention; evidence base; experience; herring; improved; intervention design; intervention development; intervention effect; interventional strategy; juvenile; juvenile human; member; parental role; programs; public health medicine (field); response; role of parent; sadness; satisfaction; success; teenage; therapy design; therapy development; treatment as usual; treatment design; treatment development; youngster","Family Therapy for Adolescent Depression: Deployment Focused Development, Phase 1"," Project Narrative  Adolescent depression is a significant public health problem. In this study, we are developing a behavioral-family therapy to treat depressive symptoms and improve family relationships. The treatment will be based on the latest research on adolescent development and depression. Our team of clinicians and researchers seek to develop a treatment that will be appropriate for use in community treatment settings.",76966,ITVC,Interventions Committee for Disorders Involving Children and Their Families,,2,237643,
7753582,R34,MH,5,,01/01/2010,12/31/2010,PAR-06-248,5R34MH080814-03,,NIMH:214624;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BALTIMORE,UNITED STATES,PSYCHIATRY,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"BENNETT, MELANIE E;",6653457;,5R34MH080814,04/01/2008,12/31/2010,"(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; After Care; After-Treatment; Aftercare; Ambulatory Care Facilities; Amfebutamone; Area; Attention; Attitude; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Bupropion; Cancer of Lung; Cardiac Diseases; Cardiac Disorders; Care, Health; Caring; Cessation of life; Cessation of smoking; Client; Clinic Visits; Communities; Conditioning Therapy; Condom; Condoms, Unspecified; Death; Dependence, Nicotine; Diabetes Mellitus; Disabled Persons; Disabled Population; Disease; Disorder; Empirical Research; Environment; Feeling; General Population; General Public; Goals; Guidelines; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Handicapped; Health; Health Care Costs; Health Costs; Health behavior change; Healthcare; Healthcare Costs; Healthcare Systems; Heart Diseases; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Infirmity; Intention; Intervention; Intervention Strategies; LAV-HTLV-III; Learning; Life; Life Style Modification; Lymphadenopathy-Associated Virus; Malignant Tumor of the Lung; Malignant neoplasm of lung; Measures; Medical; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Motivation; Nicotine Dependence; Nicotine Replacement Therapy; Obesity; Outcome; Outpatient Clinics; Patients; People with Disabilities; Perception; Persons with Disabilities; Population; Prevention of relapse; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Psychiatric therapeutic procedure; Psychological Health; Psychological reinforcement; Public Health; Pulmonary Cancer; Pulmonary malignant Neoplasm; Quality of Health Care; Quality of Healthcare; R01 Mechanism; R01 Program; RPG; Recovery; Reinforcement; Reinforcement (Psychology); Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Safety; Self Efficacy; Services; Sexual Partners; Site; Smoke; Smoking; Smoking Cessation Intervention; Smoking and Tobacco Use Cessation Interventions; Staging; Symptoms; System; System, LOINC Axis 4; Systems, Health Care; Testing; Training; Training and Education; United States; Unspecified Mental Disorder; Virus-HIV; Visit; Visits, Clinic; Work; adiposity; base; behavior change; behavior intervention; behavioral health; behavioral intervention; buproprion; cease smoking; clinical applicability; clinical application; condoms; contingency management; corpulence; corpulency; corpulentia; cost; design; designing; diabetes; disabled; disabled people; disease/disorder; disorder later incidence prevention; experience; feelings; financial incentive; follow-up; group intervention; handicapping; handicapping condition; health care quality; heart disorder; high risk; improved; innovate; innovation; innovative; intervention development; intervention effect; interventional strategy; lung cancer; meetings; mental illness; nicotine addiction; nicotine replacement; novel; obese; obese people; obese person; obese population; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; psychiatric care; psychiatric patient care; psychiatric rehabilitation; psychiatric therapy; psychiatric treatment; psychological disorder; public health medicine (field); randomized trial; response; serious mental illness; severe mental illness; sex partner; skills; skills training; smoking cessation; success; theories; therapy development; treatment development; treatment effect",An Integrated Approach to Smoking Cessation in SMI,,80814,SRNS,Mental Health Services in Non-Specialty Settings,,3,214624,
7803734,R34,MH,5,,02/01/2010,01/31/2011,PAR-06-248,5R34MH080978-02,,NIMH:235500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PSYCHIATRY,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"WEIDEN, PETER JOSEPH;",9245787;,5R34MH080978,04/13/2009,01/31/2012,"Address; Adherence; Adherence (attribute); Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Attenuated; Attitude; Behavior; Behavior Therapy, Cognitive; Behavioral Therapy; Belief; Belief System; Cell Communication and Signaling; Cell Signaling; Clinical; Cognitive Therapy; Data; Development; Diagnosis; Diagnostic; Disease model; Drugs; Employee Strikes; Evaluation; Evaluation Studies; FLR; Failure (biologic function); Funding Opportunities; Future; Goals; Grant; Health; Individual; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Label; Major Tranquilizers; Manuals; Medical; Medication; Mental disorders; Mental health disorders; Modeling; NIH Program Announcements; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Outcome; Patients; Pattern; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Pilot Projects; Population; Program Announcement; Psychiatric Disease; Psychiatric Disorder; Psychotherapy, Cognitive; Public Health; R01 Mechanism; R01 Program; RPG; Randomized; Relapse; Relative; Relative (related person); Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Schizophrenia; Schizophrenic Disorders; Services; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Strikes; Strikes, Employee; Symptoms; Testing; Therapeutic; Therapy, Cognition; Thinking; Thinking, function; Time; Tranquilizing Agents, Major; United States National Institute of Mental Health; Unspecified Mental Disorder; Work; base; behavior change; biological signal transduction; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; cohort; dementia praecox; design; designing; disorder model; drug/agent; experiment; experimental research; experimental study; failure; first episode schizophrenia; flexibility; improved; innovate; innovation; innovative; intervention development; interventional strategy; medication adherence; medication compliance; meetings; mental illness; new approaches; novel approaches; novel strategies; novel strategy; patient centered; patient oriented; patient population; pilot study; primary outcome; psychoeducation; psychological disorder; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; research study; response; schizophrenic; serious mental illness; severe mental illness; therapy development; treatment adherence; treatment as usual; treatment development; willingness",Medication Adherence in Schizophrenia: Development of a CBT-Based Intervention," Schizophrenia can be a devastating illness, but better outcomes are possible. Continued treatment with antipsychotic medication is necessary to achieve better outcomes, but nonadherence (stopping medications too soon) remains a serious and unresolved problem. This proposal has 2 main research goals that hopefully will result in new approaches to this problem. The first goal is to finalize an innovative, patient-centered therapy that we believe will help patients stay on their medications, even when the patient does not agree with the doctors about their diagnosis of schizophrenia. Second, we plan to test this treatment in a group of recently stabilized, ""first-episode"" persons diagnosed with schizophrenia who we know from other research studies will be very likely to stop their medications too soon. We will compare what happens in between groups of patients randomized to this treatment with another, more standard psychoeducation treatment, in terms of differences in attitudes towards medications, how long patients remain on medication, and their willingness to resume medications after stopping and symptoms return.",80978,ITSP,"Interventions Committee for Disorders Related to Schizophrenia, Late Life, or Personality",,2,235500,
7760652,R34,MH,5,,02/01/2010,01/31/2011,PAR-06-248,5R34MH082141-03,,NIMH:192500;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ROCHESTER,UNITED STATES,PSYCHIATRY,28,041294109,US,NY,14627,UNIVERSITY OF ROCHESTER,"CHAUDRON, LINDA H;",6199328;,5R34MH082141,02/05/2008,01/31/2011,"0-11 years old; 1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acute; Address; Adherence; Adherence (attribute); Affect; Affective Disorders; Aged 65 and Over; Antidepressant Agent; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Appointment; Availability of Health Services; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Care, Health; Caring; Child; Child Youth; Childhood; Children (0-21); Clinic; Conditioning Therapy; Data; Depression; Development; Diagnosis; Disadvantaged; Effectiveness; Effects, Longterm; Elderly; Elderly, over 65; Emotional; Enrollment; Family; Fear; Friends; Fright; General Population; General Public; Goals; Health Services Accessibility; Healthcare; Human, Child; Individual; Infant; Intervention; Intervention Strategies; Interview; Lead; Left; Life Style Modification; Long-Term Effects; Low income; Measures; Mental Depression; Mental Health; Mental Health Nurse; Mental Health Nursing; Mental Hygiene; Modeling; Mood Disorders; Morbidity; Morbidity - disease rate; Mothers; Names; Nurse Practitioners; Nurse Psychotherapist; Outcome; PROV; Pb element; Perception; Perinatal; Phase; Population; Postpartum; Postpartum Period; Preparation; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Provider; Psychiatric Nurse; Psychiatric Nursing; Psychiatric/Mental Health Nursing; Psychological Health; Psychotherapy; Randomized Controlled Trials; Recruitment Activity; Research; Research Resources; Resources; SCHED; Sample Size; Schedule; Sertraline; Site; Social Workers; Staging; System; System, LOINC Axis 4; Testing; Therapeutic Studies; Therapy Research; Time; Transportation; Vulnerable Populations; Woman; Work; Workers, Social; access to services; access to treatment; advanced age; availability of services; base; behavior intervention; behavioral intervention; care seeking; children; collaborative care; depressed mother; effective therapy; efficacy trial; elders; enroll; experience; geriatric; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; heavy metal Pb; heavy metal lead; improved; informant; intervention development; interventional strategy; late life; later life; maternal depression; model development; novel; older adult; older person; outreach; pediatric; preference; primary care setting; primary outcome; programs; randomized controlled study; recruit; satisfaction; senior citizen; therapy development; treatment adherence; treatment development; trial comparing; youngster",Adapting Collaborative Care Perinatal Depression Treatment to a Pediatric Setting,,82141,SRNS,Mental Health Services in Non-Specialty Settings,,3,192500,
7760974,R37,AA,5,,02/01/2010,01/31/2011,,5R37AA012974-10,,NIAAA:520931;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,BOSTON,UNITED STATES,NEUROLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"CHARNESS, MICHAEL EDWARD;",1882181;,5R37AA012974,05/01/2001,01/31/2011,"0-11 years old; Absolute ethanol; Adhesions; Alcohol, Ethyl; Alcohols; Apoptotic; Assay; Bioassay; Biologic Assays; Biological Assay; Birth Defects; Brain; CALL Protein; CamL1 Gene Product; Cell Adhesion; Cell Aggregation; Cell Death; Cell Surface Glycoprotein L1; Cell-Cell Adhesion; Cell-Cell Adhesion Inhibition; Cells; Cellular Adhesion; Chemical Class, Alcohol; Child; Child Youth; Children (0-21); Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; ETOH; Embryo Development; Embryogenesis; Embryonic Development; Encephalon; Encephalons; Ethanol; F11 Glycoprotein; Fibroblasts; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Goals; Grain Alcohol; Human; Human, Child; Human, General; L1 Cell Adhesion Molecule; L1CAM; Lead; Mammalian Cell; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Methods and Techniques; Methods, Other; Methylcarbinol; Mice; Microscopic; Molecular Biology, Mutagenesis; Molecular Genetic Abnormality; Morphogenesis; Murine; Mus; Mutagenesis; Mutation; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nerve Cells; Nerve Growth Factor-Inducible Large External Glycoprotein; Nerve Unit; Nervous System, Brain; Neural Adhesion Molecule L1; Neural Cell; Neural Cell Adhesion Molecule L1; Neurocyte; Neurons; Pb element; Proteins; Research; Series; Specificity; Structure; Syndrome; Techniques; Transfection; alcohol effect; children; embryo culture; ethanol effect; experiment; experimental research; experimental study; gene product; genome mutation; heavy metal Pb; heavy metal lead; in utero; mouse development; necrocytosis; neuronal; prevent; preventing; research study; youngster",ALCOHOL AND CELL ADHESION,,12974,NSS,,,10,520931,
7760120,R37,AI,5,,02/01/2010,01/31/2011,,5R37AI024643-22,,NIAID:309312;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,08,149617367,US,MA,02115,HARVARD UNIVERSITY (SCH OF PUBLIC HLTH),"HUGHES, MICHAEL DAVID;",10367948;,5R37AI024643,04/01/1987,01/31/2011,"AIDS Virus; AIDS/HIV; AIDS/HIV problem; Accounting; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Assay; Bioassay; Biologic Assays; Biological Assay; Clinical Trials; Clinical Trials, Therapy; Clinical Trials, Unspecified; Data; Diagnostic tests; Dose; Evaluation; Exposure to; Goals; HIV; HIV Infections; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immune system; Incidence; Interruption; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Methods; Modeling; Monitor; Outcome; Perinatal; Persons; Prevalence; Prevention; Protocols, Treatment; RGM; Regimen; Research; Resistance; Risk; Specificity; Staging; Statistical Methods; Structure; Surveillance Methods; T-Lymphotropic Virus Type III Infections, Human; Therapeutic Intervention; Therapeutic Trials; Therapy Clinical Trials; Time; Transmission; Treatment Efficacy; Treatment Protocols; Treatment Regimen; Treatment Schedule; Vertical Disease Transmission; Vertical Transmission; Viral Burden; Viral Load; Viral Load result; Virus-HIV; antiretroviral therapy; base; body system, allergic/immunologic; clinical investigation; design; designing; experiment; experimental research; experimental study; fight against; intervention therapy; mother to child transmission; organ system, allergic/immunologic; phase 1 study; research study; resistant; response; therapeutic efficacy; therapeutically effective; transmission process; treatment effect; vaccine efficacy",STATISTICAL METHODS IN AIDS RESEARCH,,24643,NSS,,,22,309312,
7753220,R37,AI,5,,03/01/2010,02/28/2011,,5R37AI031789-20,,NIAID:363083;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RALEIGH,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,04,042092122,US,NC,27695,NORTH CAROLINA STATE UNIVERSITY RALEIGH,"TSIATIS, ANASTASIOS A;",1869161;,5R37AI031789,07/01/1991,02/28/2013,"AIDS; AIDS Virus; Accounting; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adherence; Adherence (attribute); Adverse effects; Analysis, Data; Articulation; Award; CD4 Lymphocyte Count; CD4+ Cell Counts; CD4+ Counts; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Design; Clinical Trials, Unspecified; Conceptions; Consensus; Data; Data Analyses; Disease; Disease Progression; Disorder; Drug resistance; Evaluation; Event; Face; Foundations; Goals; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Investigators; Joints; LAV-HTLV-III; Lead; Life Style; Lifestyle; Lifestyle Factors, Unspecified; Link; Lymphadenopathy-Associated Virus; Measures; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Patients; Pb element; Process; Programs (PT); Programs [Publication Type]; Randomized; Research; Research Design; Research Personnel; Researchers; Resolution; Risk; Solutions; Statistical Methods; Study Type; Surrogate End Points; Surrogate Endpoint; T-Lymphotropic Virus Type III Infections, Human; T4 Lymphocyte Count; Techniques; Time; Time Study; Toxic effect; Toxicities; Translating; Translatings; Treatment Side Effects; Uncertainty; Viral; Viral Burden; Viral Load; Viral Load result; Virus-HIV; Work; abstracting; antiretroviral therapy; biomarker; clinical investigation; cost; design; designing; disease/disorder; doubt; drug resistant; facial; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interest; language translation; lifestyle factors; new approaches; novel; novel approaches; novel strategies; novel strategy; programs; randomisation; randomization; randomly assigned; resistance to Drug; resistant to Drug; response; side effect; study design; success; therapy adverse effect; tool; treatment adverse effect; treatment effect; treatment strategy; willingness",Statistical Methods for AIDS Clinical Trials,,31789,NSS,,,20,363083,
7753629,R37,AI,5,,02/01/2010,01/31/2011,,5R37AI032011-18,,NIAID:370138;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DALLAS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"HANSEN, ERIC JOHN;",7688469;,5R37AI032011,01/01/1992,01/31/2011,"Affect; Animals; Bacteria; Chimera Protein; Chimeric Proteins; Communicable Diseases; Data; Defense Mechanisms; Dermal; Development; Disease; Disorder; Experimental Models; Experimental Models, Other; Fusion Protein; Genital; Genital system; Gram-Negative Bacteria; H. ducreyi; H.ducreyi; Haemophilus ducreyi; Hemophilus ducreyi; Host Defense; Host Defense Mechanism; Human; Human Figure; Human body; Human, General; In Vitro; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Ingestion; Killings; Knowledge; Lesion; Liquid substance; Man (Taxonomy); Man, Modern; Models, Experimental; Molecular; Phagocytes; Phagocytic Cell; Phagocytosis; Phagocytosis Inhibition; Production; Proteins; Public Health; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Signal Pathway; Structure; ULCN; Ulcer; Ulceration; Virulence; amebocyte; disease/disorder; experiment; experimental research; experimental study; fluid; gene product; in vivo; liquid; macrophage; mutant; paralog; paralogous gene; prevent; preventing; psychological defense mechanism; public health medicine (field); research study; urogenital system (genital part)",Haemophilus ducreyi Inhibits Phagocytosis,,32011,BACP,Bacterial Pathogenesis Study Section,,18,370138,
7753584,R37,AI,5,,02/01/2010,01/31/2011,,5R37AI033493-17,,NIAID:373725;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"SEIFERT, H. STEVEN;",1885309;,5R37AI033493,05/01/1994,01/31/2013,"Accounting; Active Oxygen; Affect; Alleles; Allelomorphs; Anabolism; Antigen Variation; Antigenic Variability; Antigenic Variation; Area; Asorbicap; Assay; Award; Bacteria; Bacterial Genes; Bioassay; Biologic Assays; Biological Assay; Biology; C-Long; Ce-Vi-Sol; Cecon; Cells; Cenolate; Cetane; Cevalin; Characteristics; Competence; Conversion Hysterical Neurosis; Conversion Reaction; Conversion disorder; Cruciform DNA; DNA; DNA Recombination; DNA Repair Pathway; DNA Sequence; DNA Sequence Rearrangement; DNA recombination (naturally occurring); DNA, Cruciform; Deoxyribonucleic Acid; Disease; Disorder; Epithelial; Epithelial Cells; Event; Exhibits; Fe element; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Fimbriae Proteins; Frequencies (time pattern); Frequency; Gel; Gene Conversion; Gene Expression Profile; Gene Family; Gene Transcription; GeneHomolog; Generalized Growth; Genes; Genes, Bacterial; Genetic; Genetic Alteration; Genetic Change; Genetic Recombination; Genetic Screening; Genetic Transcription; Genetic defect; Genetics-Mutagenesis; Genomics; Goals; Gonococcal Infection; Gonococcus; Gonorrhea; Grant; Growth; H2O2; Helicase Gene; Heme; Heme b; Holliday Junction DNA; Holliday Junctions; Homolog; Homologous Gene; Homologue; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hysteria, Conversion; Immune; Immunity; Infection; Insertion Mutation; Investigators; Iron; Island; L-Threonine; Leadership; Man (Taxonomy); Man, Modern; Measurement; Mediating; Membrane; Models, Molecular; Molecular; Molecular Biology, Mutagenesis; Molecular Models; Mutagenesis; Mutation; N. gonorrhoeae; N.gonorrhoeae; Neisseria; Neisseria gonorrhoeae; Nucleic Acid Biochemistry, Molecular Modeling; Nucleic Acids; Organism; Oxygen Radicals; Paper; Pathogenesis; Pathogenicity Factors; Pathway interactions; Peer Review; Peer Review, Research; Phase; Pili Structural Proteins; Pilin; Pilum; Polyploid; Polyploidy; Position; Positioning Attribute; Principal Investigator; Pro-Oxidants; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Protein Binding; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Protoheme; Protoheme IX; Publications; Publishing; RNA Expression; RT-PCR; RTPCR; Reactive Oxygen Species; Rearrangement; Recombination; Recombination, Genetic; Reports, Progress; Research Peer Review; Research Personnel; Researchers; Reverse Transcriptase Polymerase Chain Reaction; Role; STD; Scientific Publication; Secretin; Sexually Transmitted Diseases; Sexually Transmitted Disorder; Sexually Transmitted Infection; Site; Structure; System; System, LOINC Axis 4; Threonine; Time; Tissue Growth; Transcription; Transcription, Genetic; Tumor Antigens; Tumor-Associated Antigen; Variant; Variation; Venereal Diseases; Venereal Disorders; Venereal Infections; Virulence Factors; anti-microbial; antimicrobial; base; biosynthesis; disease/disorder; ferroheme; fimbriae; gene expression signature; gene product; genome mutation; high risk; homologous recombination; living system; membrane structure; migration; molecular modeling; monolayer; mutant; ontogeny; oxidative damage; pathogen; pathway; pilus; programs; recombinase; response; reverse transcriptase PCR; social role; trafficking; transcriptome; tumor-specific antigen; uptake",Mechanisms of Gonococcal Pilin Antigenic & Phase Variation,,33493,NSS,,,17,373725,
7766910,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI034206-17,,NIAID:469260;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"RUDENSKY, ALEXANDER Y.;",1884576;,5R37AI034206,09/01/1992,01/31/2014,"APC; ATGN; Accounting; Adoptive Transfer; Affinity; Antigen-Presenting Cells; Antigens; Autoimmune; Autoimmune Diseases; Autoimmune Process; Autoimmune Status; Autoimmunity; Avidity; Binding; Binding (Molecular Function); Body Tissues; Bone Marrow; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Protection; Cell Signaling; Cells; Cells, CD4; Class II Antigens; Class II Major Histocompatibility Antigens; Commit; Complex; Cytoprotection; Dendritic Cells; Development; Distal; Epithelial Cells; Funding; Generations; Genes, Class II; Genes, HLA Class II; Genes, MHC Class II; Genetic; Hand; Histocompatibility Antigens Class II; I-A Antigen; INFLM; Ia Antigens; Ia-Like Antigens; Immune; Immune Response Antigens; Immune response; Immune-Response-Associated Antigens; Immunologic Accessory Cells; Inflammation; Intracellular Communication and Signaling; Lead; Lesion; Ligands; Lymph node proper; MHC Class II; MHC Class II Genes; MHC Class II Molecule; MHC Class II Protein; MHC class II antigen; Maintenance; Maintenances; Major Histocompatibility Complex Class II; Mammals, Mice; Mediating; Mice; Molecular Interaction; Monocytes / Macrophages / APC; Murine; Mus; Organ; Parasitic infection; Pb element; Peptide-MHC; Peptide-Major Histocompatibility Protein Complex; Peptide/MHC Complex; Peptides; Peripheral; Play; Population; Quality Control; Regulatory T-Lymphocyte; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Lymph Node; Reticuloendothelial System, Thymus; Role; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; T-Cell Receptor Interaction; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TCR Activation; TCR Interaction; Testing; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Tissues; Tumor Immunity; Veiled Cells; Viral; Work; accessory cell; autoimmune disorder; autoreactive T cell; base; biological signal transduction; cell type; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; helper T cell; host response; immunogen; immunoresponse; insight; lymph gland; lymph nodes; migration; novel; novel therapeutic intervention; pMHC; prevent; preventing; public health relevance; research study; self recognition (immune); social role; thymocyte; thymus derived lymphocyte; tool; transcription factor",Self Peptides Bound to MHC Class II In T Cell Selection," Project Narrative Regulatory T cells recently emerged as a key mechanism preventing autoimmunity and excessive tissue damage in the course of the immune response to viral, bacterial, and parasitic infections. Furthermore, these cells greatly diminish anti-tumor immunity. In studies described in this application, we will investigate the ways a functional protective repertoire of regulatory T cells is shaped during their differentiation. This work will lead to a better understanding of powerful protection against immune-inflicted damage of specific organs and tissues afforded by regulatory T cells and facilitate development of novel therapeutic approaches to treatment of autoimmune diseases.",34206,CMIB,Cellular and Molecular Immunology - B Study Section,,17,469260,
7758299,R37,AI,5,,02/01/2010,01/31/2011,,5R37AI036040-22,,NIAID:518658;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,HOUSTON,UNITED STATES,BIOCHEMISTRY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"PRASAD, BIDADI V VENKATARAM;",8284528;,5R37AI036040,12/01/1988,01/31/2013,"0-11 years old; Abscission; Address; Animals; Antibodies; BCAR3; BCAR3 gene; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Biochemical Genetics; Capsid; Cells; Child; Child Youth; Children (0-21); Collaborations; Combining Site; Complex; Crystallization; DISSEC; Data; Development; Disease; Disorder; Dissection; Double-Stranded RNA; EC 2.7; Electron Microscope; Electrons; Esteroproteases; Excision; Exhibits; Extirpation; Gastroenteritis; Gene Products, RNA; Gene Transcription; Genetic Transcription; Genetic, Biochemical; Genome; Grant; Human, Child; IFN; In Vitro; Interferons; Kinases; Life; Ligands; Medical; Methods; Methods and Techniques; Methods, Other; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecular Virology; Morphogenesis; NSP1; NSP2; NTPase; Negative Beta Particle; Negatrons; Nucleoside Triphosphate Phosphohydrolase; Nucleosidetriphosphatase; Pathway interactions; Peptidases; Peptide Hydrolases; Phosphotransferases; Process; Proteases; Proteinases; Proteins; Proteolytic Enzymes; RNA; RNA Binding; RNA Expression; RNA, Double-Stranded; RNA, Non-Polyadenylated; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Receptor Protein; Recombinants; Regulation; Removal; Research Resources; Resolution; Resources; Ribonucleic Acid; Roentgen Rays; Role; Rotavirus; SH2D3A; SH2D3A gene; SH2D3B; Site; Staining method; Stainings; Stains; Structural Protein; Structure; Surgical Removal; Techniques; Transcription; Transcription Activation; Transcription, Genetic; Transcriptional Activation; Transphosphorylases; Tripcellim; Trypsin; Up-Regulation; V (voltage); Virus; Virus Assembly; Viruses, General; X-Radiation; X-Rays; Xrays; base; children; coat (nonenveloped virus); conformation; conformational state; design; designing; dimer; disease prevention; disease/disorder; disorder prevention; dsRNA; gene product; immunogenicity; inhibitor; inhibitor/antagonist; insight; novel; nucleoside triphosphatase; particle; pathway; prevent; preventing; receptor; resection; response; social role; voltage; youngster",Structural Studies on Rotaviruses,,36040,NSS,,,22,518658,
7756669,R37,AI,5,,01/01/2010,12/31/2010,,5R37AI041239-12,,NIAID:414874;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PASADENA,UNITED STATES,NONE,29,009584210,US,CA,91125,CALIFORNIA INSTITUTE OF TECHNOLOGY,"BJORKMAN, PAMELA J;",1929583;,5R37AI041239,04/01/1997,12/31/2013,"3D image; ATGN; Address; Antibodies; Antigens; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Blood; Caliber; Cell Communication and Signaling; Cell Signaling; Cells; Chimera; Chimera Protein; Chimera organism; Chimeric Proteins; Combining Site; Common Rat Strains; Complex; Confocal Microscopy; Cryo-electron Microscopy; Cryoelectron Microscopy; Cytoplasm; Cytoplasmic Domain; Cytoplasmic Tail; Destinations; Diameter; Dimensions; Dimerization; Electron Cryomicroscopy; Electron Microscopy; Endocytosis; Endosomes; Ensure; Epithelial Cells; FRET; Face; Fc Fragments; Fc Immunoglobulins; Fc receptor, neonatal; FcRn; FcRn neonatal transfer protein; FcRn protein, human; Fluorescence Resonance Energy Transfer; Fusion Protein; Gamma Globulin, 7S; IgG; IgG Receptors; Image; Imagery; Images, 3-D; Immune Precipitation; Immunoglobulin G; Immunoglobulin G Receptor; Immunoglobulins, Fc; Immunoprecipitation; In Vitro; Intestinal; Intestines; Intracellular Communication and Signaling; Label; Life; Ligand Binding; Ligands; Liposomal; Liposomes; Location; MDCK cell; Madin Darby canine kidney cell; Mammals, Rats; Maternal antibody; Mediating; Membrane; Microscopy, Confocal; Molecular Interaction; Pathway interactions; Phosphorylation; Phosphorylation Site; Printing; Protein Dimerization; Protein Phosphorylation; Proteins; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reactive Site; Receptor Protein; Receptors, IgG; Receptosomes; Recycling; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Resolution; Reticuloendothelial System, Blood; Role; Route; Signal Transduction; Signal Transduction Systems; Signaling; Structure; System; System, LOINC Axis 4; Testing; Three-Dimensional Image; Transport Vesicles; VESCL; Vesicle; Virus; Viruses, General; Visualization; antigen binding; biological signal transduction; bowel; cryoEM; dimer; electron tomography; facial; gamma Fc Receptors; gene product; imaging; immunogen; membrane structure; mutant; nano gold; nanoGold; neonatal Fc receptor; offspring; pathogen; pathway; receptor; reconstruction; social role; trafficking",Analysis of the Neonatal Fc Receptor/IgG Interaction,,41239,NSS,,,12,414874,
7754430,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI042767-12,,NIAID:371250;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,IOWA CITY,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,02,062761671,US,IA,52242,UNIVERSITY OF IOWA,"HARTY, JOHN T.;",1892883;,5R37AI042767,04/01/1998,01/31/2013,"Animal Welfare; Bibliography; CD8; CD8B; CD8B1; CD8B1 gene; Country; Ecological impact; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Exhibits; Funding; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; International; LYT3; Memory; Names; Phenotype; Principal Investigator; Programs (PT); Programs [Publication Type]; Regulation; Research; Research Ethics Committees; Research Resources; Resources; T memory cell; T-Cells; T-Lymphocyte; Thymus-Dependent Lymphocytes; Vertebrate Animals; Vertebrates; abstracting; expiration; human subject; memory CD4 T cell; memory CD4 T lymphocyte; memory T lymphocyte; programs; thymus derived lymphocyte; vertebrata",Regulation of primary and secondary CD4 and CD8 T cell memory,,42767,ZRG1,Special Emphasis Panel,,12,371250,
7771790,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI048638-10,,NIAID:435600;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,ATLANTA,UNITED STATES,PATHOLOGY,05,066469933,US,GA,30322,EMORY UNIVERSITY,"PULENDRAN, BALI ;",6193176;,5R37AI048638,03/01/2001,01/31/2014,"APC; ATGN; Adaptor Protein; Adaptor Signaling Protein; Address; Adjuvant; Administration, Oral; Antigen-Presenting Cells; Antigens; Autoantigens; Autoimmune Status; Autoimmunity; Autologous Antigens; Cell Communication and Signaling; Cell Signaling; Color; Complex; Consensus; Cytofluorometry, Flow; Decision Making; Dendritic Cells; Drug Administration, Oral; Elements; Equilibrium; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Food; Germ; Grant; INFLM; Immune; Immune response; Immune system; Immunity; Immunity, Mucosal; Immunologic Accessory Cells; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Inflammation; Intestinal; Intestines; Intracellular Communication and Signaling; Invaded; Laboratories; Lamina Propria; Large Intestine; Lymph node proper; Mammals, Mice; Mesenteric; Mesentery; Mice; Microbe; Microfluorometry, Flow; Microorganisms, General; Monocytes / Macrophages / APC; Mucosal Immune Responses; Mucosal Immunity; Murine; Mus; Nature; Oral; Oral Administration; Peyer's Patches; Plastics; Play; Process; Property; Property, LOINC Axis 2; Reporting; Reticuloendothelial System, Lymph Node; Role; Self Tolerance; Self-Antigens; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Stromal Cells; Structure of aggregated lymphoid follicle of small intestine; Vaccine Adjuvant; Vaccines; Veiled Cells; Work; accessory cell; balance; balance function; biological signal transduction; body system, allergic/immunologic; bowel; cell fixing; cell type; commensal bacteria; commensal microbes; conditioning; flow cytophotometry; host response; immunogen; immunoresponse; infection mouth; insight; intraoral drug delivery; large bowel; lymph gland; lymph nodes; macrophage; microorganism; oral infection; oral infectious; oral vaccine; organ system, allergic/immunologic; pathogen; public health relevance; response; self recognition (immune); social role",Understanding the role of mucosal antigen presenting cells in regulating immune r," Project Narrative The immune system has the dichotomous property of being able to launch effective immunity against pathogens, while being tolerant to host antigens. This property is particularly important in the intestine, where the immune system is confronted with trillions of commensal bacteria and food antigens, which must be tolerated, whilst it remains vigilant for harmful intestinal pathogens. Although this property has been appreciated for over a century, the mechanisms by which it occurs remains poorly defined. Recently we have identified a macrophage cell type in the intestine, which suppresses inflammation. In contrast, a different cell type known as the dendritic cell seems to promote inflammation. The focus of the present proposal is to understand how these cell types regulate the decision making process with respect to immunity versus tolerance in the intestine.",48638,III,Innate Immunity and Inflammation Study Section,,10,435600,
7760633,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI050529-08,,NIAID:521752;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"HAHN, BEATRICE H;",1973980;,5R37AI050529,08/01/2001,01/31/2013,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Africa; Apes; Area; Biological; Blood Plasma; Blood Serum; Blotting, Western; Budgets; Cameroon; Cameroons; Cells; Cercocebus atys; Chimp; Chimpanzee; Cloning, Molecular; Communicable Diseases; Communities; Congo; Congo (Brazzaville); Detection; Disease; Disorder; Documentation; ELISA; Envelope Glycoprotein gp120, HIV; Enzyme-Linked Immunosorbent Assay; Epidemic; Equatorial Guinea; Evolution; Floor; Future; Gagging; Gene variant; Generalized Growth; Genetic; Genetic Diversity; Genetic Variation; Genome; Glycoproteins; Goals; Gorilla (species); Gorilla gorilla; Gorillas; Grant; Growth; HIV; HIV Envelope Protein gp120; HIV-1; HIV-2; HIV-I; HIV-II; HIV/AIDS; HIV/AIDS problem; HIV1; HIV2; HTLV-III; HTLV-III gp120; HTLV-IV; History; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type IV; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Human, General; Immunoassay; Immunodeficiency Virus Type 1, Human; Immunodeficiency Virus Type 2, Human; Immunologic Deficiency Syndrome, Acquired; In Vitro; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; LAV-2; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Mammals, Primates; Man (Taxonomy); Man, Modern; Mediating; Methods; Microbeads; Microspheres; Molecular; Molecular Cloning; Monkeys; Natural History; Nature; PBMC; Pan; Pan Genus; Pan Species; Pattern; Peptides; Peripheral Blood Mononuclear Cell; Phenotype; Phylogenetic Analysis; Phylogenetics; Plasma; Play; Pongidae; Population; Prevalence; Primates; Property; Property, LOINC Axis 2; Proteins; Public Health; Receptor Protein; Recombinants; Recording of previous events; Reflex, Pharyngeal; Relative; Relative (related person); Republic of the Congo; Research; Research Design; Research Specimen; Reticuloendothelial System, Serum, Plasma; Risk; Role; SIV; Sampling; Science; Science of Virology; Serum; Serum, Plasma; Simian Immunodeficiency Viruses; Site; Sooty Mangabey; Source; Spanish Guinea; Specimen; Study Type; Survey Instrument; Surveys; Time; Tissue Growth; Tonsil; Transmission; Tropism; United Republic of Cameroon; Vaccines; Variation (Genetics); Viral; Viral Genome; Virology; Virus; Virus-HIV; Viruses, General; Western Blotting; Western Blottings; Western Immunoblotting; Work; Zoonoses; Zoonotic Infection; allelic variant; base; disease/disorder; env Protein gp120, HIV; gene product; gp120; gp120 ENV Glycoprotein; gp120(HIV); great ape; human T cell leukemia virus III; human T lymphotropic virus III; macrophage; mouse model; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; pandemic; pandemic disease; pathogen; protein blotting; public health medicine (field); receptor; social role; study design; tonsillar; transmission process; virology",Natural SIV Reservoirs and Human Zoonotic Risk,,50529,AMCB,AIDS Molecular and Cellular Biology Study Section,,8,521752,
7768459,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI051530-08,,NIAID:411291;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,PATHOLOGY,08,047006379,US,MA,02115,HARVARD UNIVERSITY (MEDICAL SCHOOL),"BENOIST, CHRISTOPHE O;",6178589;,5R37AI051530,04/01/2002,01/31/2014,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; AKT; ATGN; ATRA; Address; Adipose tissue; Affect; Akt protein; Aldesleukin Gene; All-trans retinoic acid; Antigens; Apoptotic; Autoimmune; Autoimmune Process; Autoimmune Responses; Autoregulation; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biochemical; Body Tissues; Bone Marrow; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication and Signaling; Cell Signaling; Cells; Cells, CD4; Chimera; Chimera organism; Chronic; Clonal Deletion; Co-Stimulator; Complement; Complement Proteins; Costimulator; Data; Differentiation Factor, B-Cell; Elements; Environment; Epidermal Thymocyte Activating Factor; Equilibrium; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fatty Tissue; Frequencies (time pattern); Frequency; Funding; GALT; Gene Expression Profile; Gene variant; Genetic; Genetic Diversity; Genetic Variation; Gut associated lymphoid tissue; HPGF; Hepatocyte-Stimulating Factor; Homeostasis; Human; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFNB2; IL-2; IL-2 Gene; IL-6; IL2; IL2 Protein; IL2 gene; IL6 Protein; Immune; Immune Tolerance; Immune system; Immunologic Tolerance; Immunomodulation; In Vitro; Inbred Strain; Inbred Strains Mice; Individual; Interleukin 2; Interleukin 2 Precursor; Interleukin 2 Precursor Gene; Interleukin 6 (Interferon, Beta 2); Interleukin II; Interleukin-2; Interleukin-2 Gene; Interleukin-6; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Kinetic; Kinetics; Lead; Location; Logic; Lymphocyte; Lymphocyte Mitogenic Factor; Lymphocytic; Lymphocytopenia; Lymphoid; Lymphopenia; MGI-2; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Memory; Mice; Mice, Inbred Strains; Mitogenic Factor; Molecular; Murine; Mus; Myeloid Differentiation-Inducing Protein; Organ; PKB protein; Pathology; Pathway interactions; Pb element; Peripheral; Phenotype; Physiological Homeostasis; Plasmacytoma Growth Factor; Play; Population; Population Dynamics; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Process; Protein Kinase B; Proto-Oncogene Proteins c-akt; Quelling; RAC-PK protein; RAFT1 protein, human; RAPT1 protein, human; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Rapamune; Rapamycin; Rapamycin Target Protein; Receptor Protein; Regulation; Regulatory Pathway; Regulatory T-Lymphocyte; Reimplantation; Replantation; Reticuloendothelial System, Bone Marrow; Reticuloendothelial System, Thymus; Retinoic Acid; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Site; Skin; Specificity; Splenocyte; Stromal Cells; Surgical Replantation; T cell growth factor; T-Cell Growth Factor; T-Cell Growth Factor Gene; T-Cell Stimulating Factor; T-Cells; T-Lymphocyte; T-Lymphocyte, Regulatory; T4 Cells; T4 Lymphocytes; TCGF Gene; Testing; Thymocyte Stimulating Factor; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Tissues; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Variant; Variation; Variation (Genetics); Vitamin A Acid; Work; adipose; all-trans-Retinoic Acid; all-trans-Vitamin A acid; allelic variant; autoreactive T cell; autoreactivity; balance; balance function; biological signal transduction; body system, allergic/immunologic; c-akt protein; cytokine; day shift; experiment; experimental research; experimental study; gene expression signature; heavy metal Pb; heavy metal lead; helper T cell; human FRAP1 protein; immune modulation; immune system tolerance; immune unresponsiveness; immunogen; immunologic reactivity control; immunological paralysis; immunoregulation; in vitro testing; in vivo; insight; interferon beta 2; lymph cell; mTOR; meetings; night shift; night work; organ system, allergic/immunologic; pathway; prevent; preventing; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; public health relevance; rac protein kinase; rapamycin and FKBP12 target 1 protein, human; receptor; related to A and C-protein; research study; shift work; social role; thymocyte; thymus derived lymphocyte; trans-Retinoic Acid; transcription factor; transcriptome; tumor; white adipose tissue; yellow adipose tissue",Naive T cell homeostasis: Treg selection and survival, PROJECT NARRATIVE  These experiments will explore the cellular mechanisms and regulatory pathways that lead to variations in the differentiation and homeostasis of FoxP3+ T regulatory cells. The results should lead to a better understanding of this population that is key to immune and autoimmune regulation.,51530,CMIA,Cellular and Molecular Immunology - A Study Section,,8,411291,
7748021,R37,AI,5,,01/01/2010,12/31/2010,,5R37AI053102-08,,NIAID:630324;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"VON BOEHMER, HARALD ;",3134449;,5R37AI053102,12/01/2002,12/31/2012,"ATGN; Allergy; Antigens; Autoimmune Status; Autoimmunity; Binding; Binding (Molecular Function); CD8; CD8B; CD8B1; CD8B1 gene; Cells; Cross Presentation; Deposit; Deposition; Effector Cell; Epithelial Cells; FTOC; Fetal Thymic Organ Culture; GVHD; Gene Expression; Generations; Goals; Graft Rejection; Graft-Versus-Host Disease; Graft-vs-Host Disease; Hemagglutinin; Homologous Wasting Disease; Hypersensitivity; Immune response; Influenza HA; Influenza Hemagglutinin; Intervention; Intervention Strategies; LYT3; Ligands; Lymphatic Tissue; Lymphoid Tissue; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Mediating; Mice; Mice, Transgenic; Molecular; Molecular Interaction; Murine; Mus; Peptides; Peripheral; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Receptor Protein; Receptors, Antigen, T-Cell; Recruitment Activity; Regulation; Role; Runt Disease; Site; Specificity; T cell regulation; T-Cell Receptor; T-Cells; T-Lymphocyte; Therapeutic; Thymic epithelial cell; Thymus-Dependent Lymphocytes; Transgenic Mice; Transgenic Organisms; Translations; Transplant Rejection; Transplantation Rejection; host response; immunogen; immunoresponse; in vivo; interventional strategy; receptor; recruit; self recognition (immune); social role; thymocyte; thymus derived lymphocyte; transcription factor; transgenic",Generation of antigen-specific regulation T cells,,53102,NSS,,,8,630324,
7758731,R37,AI,5,,02/01/2010,01/31/2011,,5R37AI054636-08,,NIAID:627394;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BOSTON,UNITED STATES,,08,059709394,US,MA,02115,"IMMUNE DISEASE INSTITUTE, INC.","RAJEWSKY, KLAUS ;",7042099;,5R37AI054636,02/15/2003,01/31/2013,"ARAM; Address; Ag Recognition Activation Motif; Alleles; Allelomorphs; Antigen Presentation; Applications Grants; Area; B blood cells; B lymphoma; B-Cell Activation; B-Cell Development; B-Cell Lymphomas; B-Cell Non-Hodgkin's Lymphoma; B-Cell NonHodgkins Lymphoma; B-Cell Subsets; B-Cells; B-Lymphocyte Subsets; B-Lymphocytes; Biochemical; Budgets; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Growth and Maintenance; Cell Maintenance; Cell Signaling; Cells; Cytoplasmic Domain; Cytoplasmic Tail; EC 2.7.2-; Extracellular Signal-Regulated Kinases; Face; Feedback; Funding; Gene Targeting; Generations; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Germinal Center; Grant; Grant Proposals; Grants, Applications; HC phosphatase; Hand; Hcph gene product; HePTP; ITAM; Immunoreceptor Tyr-Based Activation Motif; Immunoreceptor Tyrosine-Based Activation Motif; Intracellular Communication and Signaling; L-Tyrosine; Label; MAP kinase; MAPK; Maintenance; Maintenances; Mature B-Cell; Mature B-Lymphocyte; Mediating; Memory B Cell; Memory B-Lymphocyte; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Molecular; Molecular Biology, Mutagenesis; Mutagenesis; Mutant Strains Mice; Mutate; Mutation; Nature; Pathogenesis; Pathway interactions; Phase; Play; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Progress Reports; Reaction; Relative; Relative (related person); Reports, Progress; Research; Role; SH-PTP1; SHP PTPase; SHP-1; SHP-1 phosphatase; SHP-1 tyrosine phosphatase; SHP1 gene product, phosphatase; SHP1 phosphatase; SHP1 protein tyrosine phosphatase; SHPTP1; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specificity; Specified; Structure of germinal center of lymph node; System; System, LOINC Axis 4; TYR; Targetings, Gene; Tyrosine; Tyrosine, L-isomer; Work; abstracting; base; biological signal transduction; cross-link; crosslink; experiment; experimental research; experimental study; facial; genome mutation; haematopoietic cell phosphatase; hematopoietic cell-specific tyrosine phosphatase SHP-1; human hematopoietic tyrosine phosphatase; in vivo; loss of function; mouse mutant; mutant; para-Tyrosine; pathway; programs; protein-tyrosine phosphatase SHP; recombinase; research study; response; social role; vector",BCR signaling during B cell development and maintenance,,54636,NSS,,,8,627394,
7769458,R37,AI,5,,02/01/2010,01/31/2011,PA-07-070,5R37AI055332-07,,NIAID:1121138;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"BURTON, DENNIS R.;",1878685;,5R37AI055332,05/15/2003,01/31/2014,"ADCC; AIDS Antibodies; AIDS Virus; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Antibodies; Antibody -dependent cell cytotoxicity; Antibody Formation; Antibody Production; Antibody Response; Antibody Specificity; Antibody-Dependent Cellular Cytotoxicity; Antigenic Determinants; Antigens; Antisera; Assay; Binding; Binding (Molecular Function); Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Blood Serum; Blood leukocyte; Cell Cytoxicity, Antibody-Dependent; Cells; Complement; Complement Proteins; Complex Mixtures; Consensus; Data; Development; Drug or chemical Tissue Distribution; Engineering; Engineerings; Ensure; Epitopes; Evaluation; Event; Fc Receptor; FcR; Gamma Globulin, 7S; Genital System, Female, Vagina; HIV; HIV Antibodies; HIV Infections; HIV vaccine; HIV-1; HIV-Associated Antibodies; HIV-I; HIV/AIDS Vaccines; HIV1; HTLV-III; HTLV-III Antibodies; HTLV-III Infections; HTLV-III-LAV Antibodies; HTLV-III-LAV Infections; Hand; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; IgG; IgG1; Immune; Immune Sera; Immune system; Immunodeficiency Virus Type 1, Human; Immunoglobulin G; In Vitro; Infection; Investigation; Killings; LAV Antibodies; LAV-HTLV-III; Laboratories; Learning; Leukocytes; Lymphadenopathy-Associated Antibodies; Lymphadenopathy-Associated Virus; Macaca; Macaque; Man (Taxonomy); Man, Modern; Marrow leukocyte; Measurement; Measures; Mediating; Metric; Modeling; Molecular Interaction; Monkeys; Phagocytes; Phagocytic Cell; Phagocytosis; Phase; Play; Property; Property, LOINC Axis 2; Receptor Protein; Reticuloendothelial System, Leukocytes; Role; Serum; Site; Source; Specificity; T-Lymphotropic Virus Type III Antibodies, Human; T-Lymphotropic Virus Type III Infections, Human; Tissue Distribution; Transmission; Vaccine Design; Vaccines; Vagina; Vaginal; Variant; Variation; Viral; Viral Activity; Viral Diseases; Viral Function; Viral Physiology; Viral Vaccines; Virus; Virus Diseases; Virus-HIV; Viruses, General; White Blood Cells; White Cell; amebocyte; antibody biosynthesis; antibody dependent cell mediated cytotoxicity; antibody receptor; body system, allergic/immunologic; design; designing; expectation; experiment; experimental research; experimental study; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunogen; immunoglobulin biosynthesis; in vitro Assay; in vivo; neutralizing antibody; neutralizing mAb; neutralizing monoclonal antibodies; organ system, allergic/immunologic; prevent; preventing; protective effect; public health relevance; receptor; research study; response; social role; transmission process; vaccine candidate; viral infection; virus infection; white blood cell; white blood corpuscle",Antibody effector function in protection against HIV-1, 7. PROJECT NARRATIVE/RELEVANCE This proposal seeks to understand how antibodies prevent HIV infection with HIV in a monkey model that is believed to mirror human infection. This understanding will help us greatly in designing vaccines that protect humans against HIV infection.,55332,ZRG1,Special Emphasis Panel,,7,1121138,
7763933,R37,CA,5,,02/01/2010,01/31/2011,PA-07-070,5R37CA008759-44,,NCI:790724;,2010,NATIONAL CANCER INSTITUTE,,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"KORNFELD, STUART A;",1870223;,5R37CA008759,09/01/1979,01/31/2014,"2-Acetamido-2-Deoxy-D-Glucose; 2-Acetamido-2-Deoxyglucose; Acetylglucosamine; Acid Maltase Deficiency Disease; Acids; Affinity; Anabolism; Animals; Binding; Binding (Molecular Function); Binding Proteins; Body Tissues; Capsid Proteins; Cell Isolation; Cell Segregation; Cell Separation; Cell Separation Technology; Cells; Clathrin; Coat Proteins; Complement; Complement Proteins; D-Glucose, 2-(acetylamino)-2-deoxy-; D-Mannose; Defect; EC 2; EC 2.7; Ear; Ear structure; Endosomes; Enzymes; Eukaryote; Eukaryotic Cell; Family; Fibroblasts; GGA adaptor protein; Generalized Glycogenosis; Genes; Genetic Alteration; Genetic Change; Genetic defect; Glycans; Glycogen storage disease type II; Glycogenosis 2; Glycogenosis Type II; Glycoproteins; Golgi; Golgi Apparatus; Golgi Complex; Golgi GGAs; Grant; Hydrolase; Individual; Kinases; Ligand Binding Protein; Lysosomal Enzyme Disorders; Lysosomal Storage Diseases; Lysosomal alpha-1,4-Glucosidase Deficiency Disease; Lysosomes; Mammals, Mice; Mannopyranose; Mannopyranoside; Mannose; Mannosidase; Mediating; Mice; Missense Mutation; Modeling; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Murine; Mus; Mutation; Mutation, Missense; N acetylglucosamine; N-Acetyl-D-Glucosamine; Nature; Oligosaccharides; Pathway interactions; Patients; Phosphorylation; Phosphotransferases; Polysaccharides; Pompe Disease; Process; Production; Protein Localization; Protein Phosphorylation; Protein Replacement Therapy; Protein Trafficking; Proteins; Receptor Protein; Receptosomes; Recombinants; Relative; Relative (related person); Research; Research Proposals; Role; Structure; Subcellular Protein Targeting; Subcellular Targeting, Physiological; Surface Plasmon Resonance; System; System, LOINC Axis 4; TGN; Testing; Time; Tissues; Transferase; Transphosphorylases; Transport Vesicles; Viral Coat Proteins; Viral Outer Coat Protein; Work; acid maltase deficiency; alpha 1,4 glucosidase deficiency; biosynthesis; cell sorting; conformation; conformational state; design; designing; enzyme replacement therapy; enzyme substrate; eukaryotida; gene cloning; gene product; genome mutation; golgi associated, gamma adaptin homologous, ADP-ribosylation factor interacting protein; in vitro Assay; inborn lysosomal enzyme disorder; intracellular protein transport; pathway; public health relevance; receptor; social role; tissue/cell culture; trans-Golgi Network","STRUCTURE, BIOSYNTHESIS & FUNCTION OF GLYCOPROTEINS", Project Narrative  This research is directly relevant to the understanding of two serious lysosomal storage diseases termed MLII and MLIII. Both are caused by mutations in the ¨/¨ and ¨ genes of Ptase. The work is also relevant to the production of lysosomal enzymes used for enzyme replacement therapy in the treatment of individuals with lysosomal storage diseases such as Fabry and Pompe disease.,8759,MBPP,Membrane Biology and Protein Processing Study Section,,44,790724,
7756593,R37,CA,5,,02/01/2010,01/31/2011,,5R37CA016303-35,,NCI:792960;,2010,NATIONAL CANCER INSTITUTE,,HOUSTON,UNITED STATES,ANATOMY/CELL BIOLOGY,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"ROSEN, JEFFREY ;",7357771;,5R37CA016303,08/01/1978,01/31/2012,"Alleles; Allelomorphs; BEK; BFR-1; Biology; Breast Milk; Cancer of Breast; Caseins; Cell Communication and Signaling; Cell Culture Techniques; Cell Polarity; Cell Signaling; Cell Survival; Cell Viability; Cells; Chemotherapy-Hormones/Steroids; Development; Dimerization; Ductal; Endocrine Gland Secretion; Enhancers; Epithelial Cells; FGF-R; FGFBR; FGFR; FGFR1; FGFR1 gene; FGFR2; FGFR2 gene; FLG Gene; FLT2 Gene; FMS-Like Gene; FMS-Like Tyrosine Kinase 2 Gene; Fibroblast Growth Factor Receptor 1 Gene; Fibroblast Growth Factor Receptor 2 Gene; Fibroblast Growth Factor Receptor Family; Fibroblast Growth Factor Receptors; Gene Expression; Genetic; Genome Instability; Genomic Instability; Goals; Hormone Receptor; Hormones; Human Milk; Human Mother's Milk; In Situ; Inflammatory; Intracellular Communication and Signaling; KGFR Gene; KSAM-1; Keratinocyte Growth Factor Receptor Gene; Knock-out; Knockout; Knockout Mice; Limulus factor C; M Phase; M phase (cell cycle); Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Mammary Gland Milk; Mammary Glands, Human; Mammary gland; Mice; Mice, Knock-out; Mice, Knockout; Mice, Transgenic; Milk Proteins; Milk, Human; Mitosis; Mitosis Stage; Modeling; Molecular; Morphogenesis; Mother Cells; Murine; Mus; NCI; NCI Organization; National Cancer Institute; Null Mouse; Pathway interactions; Pattern; Process; Progenitor Cells; Program Review Group; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Dimerization; Receptors, FGF; Role; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Staging; Stem cells; System; System, LOINC Axis 4; TK14; Therapeutic Hormone; Transgenic Mice; Transgenic Organisms; Transplantation; anticancer research; biological signal transduction; cancer progression; cancer research; cellular polarity; chromatin remodeling; developmental genetics; experiment; experimental research; experimental study; factor C; hormonal regulation; hormone regulation; horseshoe crab factor C; malignant breast neoplasm; mammary; migration; mouse model; neoplasm progression; neoplastic progression; paracrine; pathway; prevent; preventing; progenitor; research study; self-renewal; social role; stem; transcription factor; transgenic; transplant; tumor progression",Hormonal Regulation of Breast Cancer,,16303,NSS,,,35,792960,
7764783,R37,CA,5,,02/01/2010,01/31/2011,,5R37CA026504-32,,NCI:731385;,2010,NATIONAL CANCER INSTITUTE,,BRONX,UNITED STATES,ANATOMY/CELL BIOLOGY,15,110521739,US,NY,10461,ALBERT EINSTEIN COL OF MED YESHIVA UNIV,"STANLEY, E RICHARD;",1901262;,5R37CA026504,07/01/1979,01/31/2012,"ATP[{..}]protein-tyrosine O-phosphotransferase; Arthritis; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Autocrine Systems; Blood granulocytic cell; Blood leukocyte; Body Tissues; Bright Disease; CD115 Antigens; CSF-1; CSF-1-R; CSF1; CSF1R Gene Product; Cell Communication and Signaling; Cell Signaling; Cells; Chemotherapy-Hormones/Steroids; Chronic; Colony Stimulating Factor 1 Receptor; Colony-Stimulating Factor 1; Complex; Cytosolic Protein Tyrosine Phosphastase; Development; Disease; Disorder; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Endocrine Gland Secretion; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; F-Actin; Family member; Filamentous Actin; Genes, c-fms; Genital System, Female; Glomerulonephritis; Grant; Granular Leukocytes; Granulocytic cell; HCP; HCPH; HEK3; HPTP1C; Heymann Nephritis; Hormones; Inflammatory; Intracellular Communication and Signaling; L-Tyrosine; Leukocytes; Lymphoid; M-CSF; MCSF; Macrophage Colony Stimulating Factor I Receptor; Macrophage Colony-Stimulating Factor; Macrophage Colony-Stimulating Factor Receptor; Marrow leukocyte; Mediating; Metastasis; Metastasize; Metastatic Neoplasm; Metastatic Tumor; Molecular; Mononuclear; Myelogenous; Myeloid; Neoplasm Metastasis; Neoplasms; Obesity; Osteoclasts; PTK; PTP-1C; PTPN6; PTPN6 gene; PTPase; Phagocytes; Phagocytic Cell; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Play; Production; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Phosphatase; Proteins; Proto-Oncogene Protein fms; Public Health; Receptor, CSF-1; Receptors, M-CSF; Regulation; Reticuloendothelial System, Leukocytes; Role; SH-PTP1; SHP-1; SHP-1L; Secondary Neoplasm; Secondary Tumor; Signal Transduction; Signal Transduction Systems; Signaling; Structure; TYR; Therapeutic Hormone; Tissues; Tumor Cell Migration; Tumors; Tyrosine; Tyrosine Kinase; Tyrosine Phosphatase; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosyl Phosphoprotein Phosphatase; Tyrosylprotein Kinase; White Blood Cells; White Cell; adiposity; amebocyte; arthritic; atheromatosis; atherosclerotic vascular disease; autocrine; biological signal transduction; body system, reproductive, female; c fms; c-fms Protein; c-fms Proto-Oncogenes; cancer metastasis; cancer progression; corpulence; corpulency; corpulentia; disease/disorder; female reproductive system; gene product; granulocyte; gynecologic body system; hydroxyaryl protein kinase; macrophage; neoplasia; neoplasm progression; neoplastic growth; neoplastic progression; novel; obese; obese people; obese person; obese population; organ system, female reproductive; organ system, gynecologic; para-Tyrosine; paracrine; protein tyrosine phosphate phosphohydrolase; public health medicine (field); response; social role; tumor; tumor progression; tyrosyl protein kinase; white blood cell; white blood corpuscle",Regulation of Granulocyte and Macrophage Production,,26504,NSS,,,32,731385,
7760844,R37,CA,5,,02/01/2010,01/31/2011,,5R37CA030488-30,,NCI:191877;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,BIOCHEMISTRY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"GOFF, STEPHEN PAINE;",1871800;,5R37CA030488,08/01/1981,01/31/2014,"Alleles; Allelomorphs; Antimorphic mutation; Antiviral Agents; Antiviral Drugs; Antivirals; Assay; Authorization; Authorization documentation; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biochemical; Biologic Assays; Biological Assay; Burn injury; Burns; Capsid; Capsid Proteins; Cell Culture Techniques; Cell Line; Cell Lines, Strains; CellLine; Cells; Cellular Matrix; Cities; Coat Proteins; Complex; Cytoskeletal System; Cytoskeleton; Dependence; Disclosure; Doctor of Philosophy; Dominant Negative; Dominant-Negative Mutant; Dominant-Negative Mutation; EC 2; Event; Face; Family; Funding; Fusion Proteins, gag-pol; Gagging; Gel; Gene Products, RNA; Gene Products, gag; Gene Products, pol; Genes; Genes, Viral; Genetic; Genetic Alteration; Genetic Change; Genetic analyses; Genetic defect; Golf; Human Resources; Immunologic, Luciferase; In Vitro; Information Disclosure; Instruction; Intervention; Intervention Strategies; Investigators; Last Name; Libraries; Life Cycle; Life Cycle Stages; Ligand Binding Protein; Link; Luciferases; M-MuLV; Manpower; Mediating; Membrane; Method LOINC Axis 6; Methodology; Methods; MoMuLV; Modification; Molecular Interaction; Moloney Leukemia Virus; Moloney Murine Virus; Moloney Virus; Moloney murine leukemia virus; Mutation; Names; New York; Nuclear; Performance; Permission; Ph.D.; PhD; Play; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Printing; Programs (PT); Programs [Publication Type]; Protein Binding; Proteins; Quelling; R01 Mechanism; R01 Program; RNA; RNA Binding; RNA Interference; RNA Silencing; RNA Silencings; RNA, Non-Polyadenylated; RNA-Binding Proteins; RNAi; RPG; Reagent; Recombinants; Reflex, Pharyngeal; Reporter; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Resistance; Retroviral Antigen gag Protein; Retroviridae; Retroviruses; Ribonucleic Acid; Ribosomal Proteins; Role; Sequence-Specific Posttranscriptional Gene Silencing; Site; Specificity; Staging; Structure; System; System, LOINC Axis 4; Testing; Transferase; Translations; Two Hybrid; Universities; Viral; Viral Coat Proteins; Viral Diseases; Viral Genes; Viral Genome; Viral Outer Coat Protein; Viral gag Proteins; Virion; Virus; Virus Diseases; Virus Particle; Virus Replication; Virus-Retrovirus; Viruses, General; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yeasts; base; coat (nonenveloped virus); cultured cell line; experiment; experimental research; experimental study; facial; gag Antigens; gag Gene Products; gag Polyproteins; gag Protein; gag-pol Fused Protein; gag-pol Fusion Proteins; gag-pol Protein; gene product; gene replacement; genetic analysis; genome mutation; group specific antigen; in vivo; insight; interventional strategy; intracellular skeleton; knock-down; life course; membrane structure; mutant; novel; overexpression; particle; personnel; pol Gene Products; pol Polyproteins; pol Protein; pol gene product (retrovirus); programs; research study; resistant; restoration; social role; viral infection; viral resistance; virus infection; virus multiplication; yeast two hybrid system",Construction and Analysis of Retrovirus Mutants,,30488,NSS,,,30,191877,
7778340,R37,CA,5,,02/01/2010,01/31/2011,,5R37CA031798-30,,NCI:1004907;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,059709394,US,MA,02115,"IMMUNE DISEASE INSTITUTE, INC.","SPRINGER, TIMOTHY A;",1880594;,5R37CA031798,07/01/1981,01/31/2014,"ATGN; Affinity; Antibodies; Antigens; Autoimmune Diseases; Binding; Binding (Molecular Function); Binding Site Domain; Blood Vessels; CD54 (ICAM 1); CD54 Antigens; Cell surface; Chimera; Chimera organism; Clinical; Clinical Trials; Clinical Trials, Unspecified; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Extracellular Matrix, Integrins; Glycoprotein ICAM 1 (human clone pHRVr1 deblocked protein moiety reduced); Grant; Homing; ICAM-1; Immune response; Integrin alphaLbeta2; Integrins; Intercellular Adhesion Molecules; Intercellular adhesion molecule 1; LFA; Label; Leg; Leukocyte Function Associated Antigen-1; Leukocyte Trafficking; Ligand Binding Domain; Ligands; Lymphocyte Function-Associated Antigen-1; Measures; Medication; Molecular; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Molecules, Intercellular Adhesion; Pharmaceutic Preparations; Pharmaceutical Preparations; Psoriasis; Raptiva; Structure; autoimmune disorder; clinical investigation; conformation; conformational state; drug/agent; efalizumab; flexibility; host response; immunogen; immunoresponse; inhibitor; inhibitor/antagonist; lymphocyte function associated antigen; mutant; psoriasiform; psoriatic; psoriatiform; small molecule; tumor; vascular",LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS,,31798,NSS,,,30,1004907,
7752838,R37,CA,5,,01/28/2010,12/31/2010,,5R37CA058596-18,,NCI:436192;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"HABER, DANIEL A.;",1886076;,5R37CA058596,01/01/1993,12/31/2011,"0-11 years old; Affect; Anti-Oncogenes; Antioncogenes; C elegans; C.elegans; CHIP assay; Caenorhabditis elegans; Cancers; Candidate Disease Gene; Candidate Gene; ChIP (chromatin immunoprecipitation); Child; Child Youth; Childhood; Childhood Neoplasm; Childhood Tumor; Children (0-21); Classification; Comparative Genome Hybridization; Development; Elements; Embryonic Tissue, Placenta; Emerogenes; Epithelial Cells; Evolution; GFAC; GUD; Gene Targeting; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, WT1 Wilms Tumor; Genes, Wilm's; Genes, Wilms; Genes, Wilms Tumor; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Human; Human WT1 Genes; Human, Child; Human, General; Isoforms; Kidney; Kidney Cancer; Kidney Carcinoma; Lead; Link; Malignant; Malignant - descriptor; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Modeling; Mutation; Nephroblastoma; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Organ; Ortholog; Orthologous Gene; Pb element; Pediatric Neoplasm; Pediatric Tumor; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Polycomb; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Isoforms; Public Health; R01 Mechanism; R01 Program; RNA Splicing; RPG; Regulation; Renal Cancer; Renal Wilms' Tumor; Renal carcinoma; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Specimen; Role; Site; Specimen; Splicing; Stromal Cells; Systematics; Targetings, Gene; Tumor Suppressing Genes; Tumor Suppressor Genes; Urinary System, Kidney; Variant; Variation; WAGR; WT1; WT1 Genes, Human; WT1 gene; WT33; Wilm's Tumor; Wilms Tumor; Wilms Tumor 1; Wilms Tumor Genes; Wilms' Tumor of the Kidney; Zinc Finger Domain; Zinc Finger Motifs; Zinc Fingers; children; chromatin immunoprecipitation; comparative genomic hybridization; fork head protein; forkhead protein; forkhead transcription factors; genome mutation; heavy metal Pb; heavy metal lead; improved; malignancy; neoplasm/cancer; novel; oncosuppressor gene; pediatric; precursor cell; programs; public health medicine (field); renal; social role; transcription factor; tumor; tumorigenesis; youngster",Functional Properties of the Wilms' Tumor Gene WT1,,58596,NSS,,,18,436192,
7777859,R37,CA,5,,03/01/2010,02/28/2011,,5R37CA058976-18,,NCI:410916;,2010,NATIONAL CANCER INSTITUTE,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"GIANCOTTI, FILIPPO G;",1884497;,5R37CA058976,01/01/1994,02/28/2011,"1-Phosphatidylinositol 3-Kinase; A9 Antigen; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Adhesions; Award; Basal lamina; Basement membrane; Binding; Binding (Molecular Function); Breast Neoplasms; Breast Tumors; C-terminal; Cell Communication and Signaling; Cell Signaling; Cytoplasmic Domain; Cytoplasmic Tail; Data; Defect; Dephosphorylation; Endothelial Cells; Extracellular Matrix, Integrins; Generalized Growth; Glycoprotein GP-2; Growth; Hemidesmosomes; Integrin Binding; Integrin alpha6beta4; Integrins; Intracellular Communication and Signaling; Laminin; Laminin-5 Receptor (alpha6beta4 Integrin); Lymphangiogeneses; Lymphangiogenesis; Mammals, Mice; Mammary Cancer; Mammary Neoplasms; Mammary Tumorigenesis; Mediating; Mice; Molecular Analysis; Molecular Interaction; Murine; Mus; PI-3 Kinase; PI-3K; PI3-Kinase; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Phosphorylation; Play; Protein Dephosphorylation; Protein Phosphorylation; Protein-Tyrosine Kinases, src; Proteins; PtdIns 3-Kinase; Role; Signal Transduction; Signal Transduction Systems; Signaling; TSP-180; Tail; Tissue Growth; Tumor Angiogenesis; Tumor Specific Protein-180 Complex; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Wound Healing; Wound Repair; alpha(6)beta(4) Epithelial Integrin; alpha(6)beta(4) Integrin; alpha6 beta4 Integrin; angiogenesis; biological signal transduction; epiligrin; experiment; experimental research; experimental study; gene product; kalinin; laminin-5; mammary tumor; neuronal guidance; nicein; ontogeny; research study; response; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; tissue repair",Molecular Analysis of the alpha6beta4 Integrin,,58976,NSS,,,18,410916,
7769465,R37,CA,5,,01/22/2010,12/31/2010,,5R37CA071692-14,,NCI:348711;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,071723621,US,MA,02215,BETH ISRAEL DEACONESS MEDICAL CENTER,"PANDOLFI, PIER PAOLO ;",1881582;,5R37CA071692,09/15/1996,12/31/2010,"5q Deletion; 5q-; AML - Acute Myeloid Leukemia; Acute Promyelocytic Leukemia; Apoptosis; Apoptosis Pathway; B23; BING2; Biochemical; Biological Function; Biological Process; Biology; Blood (Leukemia); Cancers; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Death, Programmed; Cell Signaling; Cells; Chimera Protein; Chimeric Proteins; Chromosome 17; Chromosomes, Human, Pair 17; Cytosol; DAP6; DAXX; DAXX gene; DNA Alteration; DNA mutation; Data; Development; Disease; Disorder; Dysmyelopoietic Syndromes; EAP1; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Fibroblasts; Fusion Protein; Gene Alteration; Gene Mutation; Gene Proteins; Gene Targeting; Gene Transcription; GeneHomolog; Generations; Genes; Genes, p53; Genetic Transcription; Genetic mutation; Germ; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; Homolog; Homologous Gene; Homologue; Human; Human, General; In Vitro; Intracellular Communication and Signaling; Isoforms; Knock-out; Knockout; Knockout Mice; Leukemia, Myelocytic, Acute; Leukemias, General; Leukemogenesis/Lymphomagenesis; Loss of Chromosome 5q; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Man (Taxonomy); Man, Modern; Maps; Methods and Techniques; Methods, Other; Mice; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Molecular; Mother Cells; Murine; Mus; Mutant Strains Mice; Myeloblastic Leukemia, Acute; Myelodysplastic Syndromes; Myelogenous Leukemia, Acute; Myeloid Leukemia, Acute, M3; NLS Peptide; NPM; NPM1; NPM1 gene; NUMATRIN; Nuclear; Nuclear Localization Signal; Nuclear Localization Signal Peptide; Null Mouse; Oncogene Products; Oncogene Proteins; Oncogenesis; Oncogenic; Oncoproteins; P53; PLZF; Pathogenesis; Pathway interactions; Patients; Play; Predisposition; Progenitor Cells; Progranulocytic Leukemia; Property; Property, LOINC Axis 2; Protein Gene Products; Protein Isoforms; Proteins; RAR alpha; RARA; RARalpha; RNA Expression; Reciprocal Translocation; Recurrent disease; Relapsed Disease; Role; Sampling; Sequence Alteration; Series; Signal Transduction; Signal Transduction Systems; Signaling; Smoldering Leukemia; Sonic Hedgehog (Shh) Pathway; Sonic Hedgehog Pathway; Staging; Stem Cell Leukemia; Stem cells; Susceptibility; Syndrome; TP53; TP53 gene; TRP53; Targetings, Gene; Techniques; Testing; Transcription; Transcription, Genetic; Translating; Translatings; Tumor Protein p53 Gene; Tumor Suppression; Tumor Suppression, Molecular; ZNF145; ZNF145 gene; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; biological signal transduction; chromosome 5q loss; cofactor; del(5q); disease/disorder; fusion gene; gene product; hDAXX; in vivo; language translation; leukemia; leukemogenesis; malignancy; mouse mutant; mutant; myelodysplasia; neoplasm/cancer; novel; pathway; promyelocytic leukemia; protein function; retinoic acid receptor alpha; self-renewal; social role; stem cell biology; transcription factor; tumor; tumor growth; tumorigenesis",X-RAR alpha proteins: Molecualr Pathogenesis of Acute Promyelocytic Leukemia,,71692,CAMP,Cancer Molecular Pathobiology Study Section,,14,348711,
7755812,R37,CA,5,,02/01/2010,01/31/2011,,5R37CA072614-14,,NCI:310254;,2010,NATIONAL CANCER INSTITUTE,,SAN FRANCISCO,UNITED STATES,PEDIATRICS,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"SHANNON, KEVIN M;",6381554;,5R37CA072614,02/15/1997,01/31/2012,"Adoptive Transfer; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Award; BCR-ABL; BCR-ABL Oncoprotein; BCR-ABL Protein Tyrosine Kinase; BCR/ABL; BPTP3; Behavior; Biochemical; Blood (Leukemia); Bone Marrow Blood-Deriving Cell; Bone Marrow Blood-Forming Cell; Bone Marrow Cells; C-K-RAS; CFC; Cancer Biology; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Emerogenes; Enzymes; FLR; Failure (biologic function); Family; Fusion Proteins, bcr-abl; GAP Proteins; GM-CSF; GMCSF; GTPase-Activating Proteins; Generalized Growth; Generations; Genes; Genes, Cancer Suppressor; Genes, Neurofibromatosis 1; Genes, Onco-Suppressor; Genes, nf 1; Genetic; Genetic Alteration; Genetic Change; Genetic Models; Genetic defect; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Growth; Hematopoietic; Hepatic Cells; Hepatic Parenchymal Cell; Hepatocyte; Histamine-Producing Cell-Stimulating Factor; Imatinib mesylate; In Vitro; Insertional Mutagenesis; Intracellular Communication and Signaling; Investigation; K-RAS2A; K-RAS2B; K-Ras 2A; KRAS; KRAS2; KRAS2 gene; Ki-RAS; Knock-in; Knock-in Mouse; Lesion; Leukemia, Granulocytic; Leukemias, General; Leukemogenesis/Lymphomagenesis; Liver Cells; Malignant; Malignant - descriptor; Malignant Cell; Mammals, Mice; Mice; Modeling; Models, Genetic; Molgramostin; Mother Cells; Mouse Strains; Murine; Mus; Mutagenesis, Insertional; Mutation; Myelocytic Leukemia; Myelogenous; Myelogenous Leukemia; Myeloid; Myeloid Cells; Myeloid Disease; Myeloid Leukemia; Myeloid Malignancy; Myeloid Neoplasm; Myeloid Tumor; Myeloproliferative Disorders; Myeloproliferative Tumors; Myeloproliferative disease; NF1 gene; NS1; Non-Lymphoblastic Leukemia; Non-Lymphocytic Leukemia; Oncogene K-Ras; Oncogene, K-Ras-2; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenic; PTP-1D; PTP2C; PTPN11; PTPN11 gene; Pathway interactions; Play; Point Mutation; Process; Progenitor Cells; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RASK2; Ras Inhibitor; Role; SH-PTP2; SH-PTP3; SHP-2; SHP2; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Stem cells; TC-GM-CSF; Testing; Therapeutic; Therapeutic Intervention; Tissue Growth; Transplantation; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor-Cell Human GM Colony-Stimulating Factor; bcr-abl Fusion Proteins; biological signal transduction; cancer cell; cultured cell line; drug discovery; failure; gene product; genome mutation; granulocyte macrophage colony stimulating factor; guanosinetriphosphatase activating protein; immortalized cell; in vivo; inhibitor; inhibitor/antagonist; intervention therapy; leukemia; leukemogenesis; mouse model; mutant; myeloid granulocytic leukemia; myeloproliferative neoplasm; myelosis; neurofibromatosis type 1 gene; novel; oncosuppressor gene; ontogeny; pathway; preclinical study; ras GTPase-Activating Proteins; ras-GAPs; response; social role; stem; transplant; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog",Translational Investigation of KRas & NF1 in Myeloid Leukemia,,72614,CAMP,Cancer Molecular Pathobiology Study Section,,14,310254,
7780021,R37,CA,5,,03/01/2010,02/28/2011,,5R37CA089441-10,,NCI:666343;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,BIOCHEMISTRY,08,039318308,US,MA,02111,TUFTS UNIVERSITY BOSTON,"COFFIN, JOHN M;",1892708;,5R37CA089441,02/05/2001,02/28/2011,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Antigen Variation; Antigenic Variability; Antigenic Variation; Antiviral Agents; Antiviral Drugs; Antivirals; Area; Assay; Back; Bioassay; Biologic Assays; Biological Assay; Biology; Cancer Genes; Cancer of Breast; Cancer-Promoting Gene; Cancers; Canine Species; Canis familiaris; Cells; Chickens; Complex; DNA Recombination; DNA Sequence Rearrangement; DNA recombination (naturally occurring); Disease; Disorder; Dogs; Dorsum; Drug resistance; ENV; Employee Strikes; Event; Evolution; Exhibits; Family; Fossils; Future; Gallus domesticus; Gallus gallus; Gallus gallus domesticus; Gene Therapy Vectors; Gene Transcription; Gene Transduction Agent; Gene Transduction Vectors; Gene Transfer Clinical; Gene Transfer Procedure; Gene variant; Gene-Tx; Generations; Genes; Genes, env; Genetic Alteration; Genetic Change; Genetic Diversity; Genetic Intervention; Genetic Phenomena; Genetic Polymorphism; Genetic Recombination; Genetic Transcription; Genetic Variation; Genetic defect; Genome; Genome Instability; Genomic Instability; HERVs; HIV; HTLV-III; History; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; In Vitro; Infection; Intervention, Genetic; Investigation; LAV-HTLV-III; Laboratories; Left; Location; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Dogs; Mammals, Mice; Mammals, Primates; Man (Taxonomy); Man, Modern; Math Models; Mediating; Mice; Modeling; Molecular Biology, Gene Therapy; Murine; Mus; Mutation; Oncogenes; Phylogenetic Analysis; Phylogenetics; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Sizes; Pressure; Pressure- physical agent; Primates; Process; Property; Property, LOINC Axis 2; Proteins; Proviruses; Public Health; Quail; RNA Expression; Rearrangement; Receptor Cell; Receptor Protein; Recombination; Recombination, Genetic; Recording of previous events; Relative; Relative (related person); Resistance; Retroviridae; Retroviruses; Retroviruses, Human Endogenous; Role; SUBGP; Science; Specificity; Strikes; Strikes, Employee; Subgroup; System; System, LOINC Axis 4; Testing; Therapy, DNA; Time; Transcription; Transcription, Genetic; Transforming Genes; Vaccine Design; Variant; Variation; Variation (Genetics); Viral; Virulence; Virus; Virus Replication; Virus-HIV; Virus-Retrovirus; Virus-like particle; Viruses, General; Work; allelic variant; canine; cell type; disease/disorder; domestic dog; drug development; drug resistant; env Genes; experiment; experimental research; experimental study; gene product; gene therapy; genetic therapy; genome mutation; hazard; in vitro Model; in vivo; interest; malignancy; malignant breast neoplasm; mathematical model; mathematical modeling; member; mutant; neoplasm/cancer; polymorphism; pressure; public health medicine (field); receptor; receptor binding; research study; resistance to Drug; resistant; resistant to Drug; response; social role; theories; tool; virus multiplication; viruslike particle",Retrovirus Evolution,,89441,VIRA,Virology - A Study Section,,10,666343,
7763922,R37,DA,5,,01/01/2010,12/31/2010,PA-07-070,5R37DA005147-22,,NIDA:613587;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,PSYCHOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"IACONO, WILLIAM G;",1892474;,5R37DA005147,09/30/1987,12/31/2013,"12-20 years old; 21+ years old; AOD use; Accounting; Active Follow-up; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Affect; Age; Alcohol or Other Drugs use; Alcohols; Biological; Brain; Chemical Class, Alcohol; Childhood; Controlled Study; Cross Sectional Analysis; Cross-Sectional Analyses; Cross-Sectional Studies; Cross-Sectional Survey; DSM; Data; Data Set; Dataset; Development; Developmental Process; Diagnosis; Diagnostic and Statistical Manual; Disease Frequency Surveys; Drug usage; Drugs, Illicit; Dysfunction; EEG; Effects, Longterm; Electroencephalography; Employment; Encephalon; Encephalons; Ensure; Epidemiology, Family Medical History; Evaluation; Event; Event-Related Potentials; Exposure to; FLR; Failure (biologic function); Family; Family Medical History; Family Study; Family history of; Functional disorder; Genes; Genetic; Hereditary; Human, Adult; Illicit Drugs; Individual; Inherited; Life; Link; Literature; Long-Term Effects; Marriage; Measures; Mental Health; Mental Hygiene; Methods; Minnesota; Modeling; Nature; Nervous System, Brain; Neurocognitive; Nicotine; Occupational; Outcome; Parents; Participant; Personality Traits; Persons; Physiopathology; Preventive; Process; Protocol; Protocols documentation; Psychological Health; Psychology, Physiologic; Psychology, Physiological; Psychopathology; Psychophysiological; Psychophysiology; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Recruitment Activity; Research; Rest; Risk; Risk Factors; Social Development; Social support; Stress; Substance Use Disorder; Substance abuse problem; Testing; Tobacco; Twin Multiple Birth; Twin Studies; Twins; abnormal psychology; abuse of substances; adolescence (12-20); adolescent substance abuse; adolescent substance use; adult human (21+); adult youth; cohort; design; designing; disinhibitory psychopathology; drug use; early adolescence; emerging adult; event related potential; failure; follow up assessment; follow-up; high risk; indexing; informant; juvenile; juvenile human; male; neuropsychological; neurotoxic; pathophysiology; pediatric; peer; population based; prospective; psycho-physiological; public health relevance; recruit; social; social support network; substance abuse; substance abuser; substance use; success; teacher; teenage; young adult; youth substance abuse; youth substance use",Twin Family Study of Vulnerability to Substance Abuse," PROJECT NARRATIVE Adolescent substance abuse is a powerful predictor of adult adjustment and mental health, but the mechanisms linking early abuse to later maladjustment are not fully understood. Using twins studied prospectively from age 11 to 29, we will examine how adolescent-onset substance abuse affects the development of mental health in young adulthood.",5147,BGES,Behavioral Genetics and Epidemiology Study Section,,22,613587,
7755365,R37,DA,5,,01/01/2010,12/31/2010,,5R37DA006668-17,,NIDA:456927;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,CINCINNATI,UNITED STATES,,01,071284913,US,OH,452293039,CHILDREN'S HOSPITAL MED CTR (CINCINNATI),"DEY, SUDHANSU K;",1867098;,5R37DA006668,07/01/1990,12/31/2012,"5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-; 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)-; 5,8,11,14-eicosatetraenoylethanolamide; Adrenergic Agents; Adrenergic Drugs; Adrenergics; Affect; Biological; Blastocyst; Blastocyst structure; Blastosphere; Cannabinoids, Endogenous; Cell Communication and Signaling; Cell Signaling; Cells; Complex; Development; Embryo; Embryo Development, Preimplantation; Embryo, Preimplantation; Embryonic; Endocannabinoids; Event; Fallopian Tubes; Fecundability; Fecundity; Fertility; Gene Expression; Genital System, Female, Uterus; Gestation; Goals; Health, Reproductive; Intracellular Communication and Signaling; Mammalian Oviducts; Molecular Genetic; Molecular Genetics; N arachidonoyl 2 hydroxyethylamide; N-(2-hydroxyethyl)arachidonamide; Pattern; Physiologic; Physiological; Population; Pre-implantation Embryo Development; Pregnancy; Pregnancy Outcome; Process; Regulation; Reproductive Health; Research; Role; Salpinx; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Time; Uterine Tubes; Uterus; Woman; abused drugs; adrenergic; anandamide; anandamide (20.4,n-6); arachidonoyl ethanolamide; arachidonoylethanolamide; arachidonylethanolamide; biological signal transduction; blastocyst; blastula; drug of abuse; drugs abused; drugs of abuse; implantation; improved; lipid mediator; mouse model; oviduct; preimplantation; social role; womb",Endocannabinoid Signaling During Early Pregnancy,,6668,NSS,,,17,456927,
7769557,R37,DA,5,,02/01/2010,01/31/2011,,5R37DA007304-19,,NIDA:336353;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,MINNEAPOLIS,UNITED STATES,PHARMACOLOGY,05,555917996,US,MN,554552070,UNIVERSITY OF MINNESOTA TWIN CITIES,"THAYER, STANLEY A;",1881488;,5R37DA007304,03/15/1992,01/31/2014,"AIDS; AIDS Dementia; AIDS Dementia Complex; AIDS Virus; AIDS with dementia; AIDS-related dementia; Abscission; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immune Deficiency Syndrome related dementia; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Acute; Affect; Ammon Horn; Anti-emetics; Antiemetic Agents; Antiemetic Drugs; Antiemetics; ApoE Receptor; Appetite Stimulants; Appetite-Stimulating Drugs; Assay; Automobile Driving; Axon Terminals; Back; Bioassay; Biologic Assays; Biological Assay; Cannabinoids; Cell Death; Cell Death Process; Cell Survival; Cell Viability; Cells; Chronic; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Cornu Ammonis; DLG4; DLG4 gene; Data; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Detection; Disease; Disorder; Dissociation; Disturbance in cognition; Dorsum; Drivings, Automobile; Drugs; Electromagnetic, Laser; Envelope Glycoprotein gp120, HIV; Equilibrium; Excision; Excitatory Neurotoxins; Excitotoxin; Exposure to; Extirpation; FP593; Foundations; Funding; GFP; Glutamates; Green Fluorescent Proteins; HIV; HIV Dementia; HIV Envelope Protein gp120; HIV associated dementia; HIV-1; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-I; HIV-related dementia; HIV1; HTLV-III; HTLV-III gp120; Hippocampus; Hippocampus (Brain); Hortega cell; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Image; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Impaired cognition; In Vitro; Inflammatory; Investigators; Knowledge; L-Glutamate; LAV-HTLV-III; LDL-Receptor Related Protein 1; Lasers; Lead; Li+ element; Lipoproteins; Lithium; Location; Low Density Lipoprotein Receptor-Related Protein; Low-Density-Lipoprotein Receptor-Related Protein-1; Lymphadenopathy-Associated Virus; Medication; Microglia; Morphology; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; Nerve Cells; Nerve Endings, Presynaptic; Nerve Unit; Neural Cell; Neurocognitive; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Neurotoxins; P38 Membrane Protein, Synaptic Vesicle; PSD-95; PSD95; Pathway interactions; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Presynaptic Terminals; Process; Programs (PT); Programs [Publication Type]; Protein Binding; Protein P38, Synaptic Vesicle; Proteins; Radiation, Laser; Receptor Protein; Receptor, Apo E; Receptor, Apolipoprotein E; Receptors, N-Methylaspartate; Recovery; Removal; Research Personnel; Researchers; SAP90; Scaffolding Protein; Scanning; Signal Pathway; Site; Stimulus; Surgical Removal; Synapses; Synaptic; Synaptic Boutons; Synaptic Terminals; Synaptophysin; TAT; Testing; Trans-Activation of Transcription Protein; Trans-Activator of Transcription of HIV; Transactivating Regulatory Protein; Treatment Period; Virus-HIV; abused drugs; alpha-2-Macroglobulin Receptor; alpha2-Macroglobulin Signaling Receptor; balance; balance function; base; cognitive dysfunction; cognitive loss; cognitively impaired; density; disease/disorder; drFP583; driving; drug development; drug of abuse; drug/agent; drugs abused; drugs of abuse; ds red protein; dsFP593; env Protein gp120, HIV; excitotoxicity; experiment; experimental research; experimental study; gene product; genetic inhibitor; gitter cell; gp120; gp120 ENV Glycoprotein; gp120(HIV); heavy metal Pb; heavy metal lead; hippocampal; human T cell leukemia virus III; human T lymphotropic virus III; imaging; improved; improved functioning; insight; mesoglia; microglial cell; microgliocyte; necrocytosis; neurodegenerative illness; neuron toxicity; neuronal; neuronal survival; neuronal toxicity; neurotoxic; neurotoxicant; neurotoxicity; pathway; perivascular glial cell; postsynaptic; prevent; preventing; programs; protein complex; receptor; red fluorescent protein; release factor; research study; resection; synapse formation; synapse function; synaptic function; synaptogenesis; tat Protein; tool; treatment days; treatment duration; ubiquitin ligase",HIV Neurotoxicity-Mechanism & Modulation by Cannabinoids,,7304,NSS,,,19,336353,
7764735,R37,DA,5,,03/01/2010,02/28/2011,,5R37DA007348-17,,NIDA:423002;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"WEISS, FRIEDBERT ;",1866402;,5R37DA007348,08/15/1991,02/28/2014,"8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Acute; Addiction, Cocaine; Addiction, Drug; Address; Affect; Agonist; Ammon Horn; Animal Model; Animal Models and Related Studies; Animals; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anxiety; Anxiolytic Agents; Anxiolytics; Attenuated; Award; Behavior; Behavioral; Brain; Brain region; CNS plasticity; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Chronic; Circulatory Collapse; Clinical; Cocaine; Cocaine Dependences; Common Rat Strains; Complement; Complement Proteins; Cornu Ammonis; Cues; Data; Dependence, Drug; Dependences, Cocaine; Development; Dopamine Reuptake Inhibitors; Dopamine Uptake Inhibitors; Dorsal; Dose; Drug Addiction; Drug Dependency; Drug Interactions; Drugs; Encephalon; Encephalons; Exposure to; Extinction; Extinction (Psychology); FOS gene; Family; Figs; Figs - dietary; Funding; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G0S7; GPRC1E; GRM5; GRM5 gene; Glutamates; Goals; Grant; Hand; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Hippocampus; Hippocampus (Brain); History; Human; Human, General; Incentives; Individual; Instruction; Intake; Intracellular Communication and Signaling; Intravenous; Investigation; Investigators; L-Glutamate; Lead; Left; Ligands; Location; MGLUR5; MGLUR5A; MGLUR5B; Maintenance; Maintenances; Mammals, Rats; Man (Taxonomy); Man, Modern; Maps; Measures; Mediating; Medication; Mental disorders; Mental health disorders; Metabotropic Glutamate Receptors; Methods; Milk; Modeling; Modification; Moods; Nature; Nervous; Nervous System, Brain; Neurobiology; Neuronal Plasticity; Neurosciences; Operation; Operative Procedures; Operative Surgical Procedures; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Play; Positive Reinforcer; Predisposition; Prefrontal Cortex; Prevention of relapse; Principal Investigator; Probability; Procedures; Process; Programs (PT); Programs [Publication Type]; Protooncogene FOS; Psychiatric Disease; Psychiatric Disorder; Psychological reinforcement; Rat; Rattus; Receptor Activation; Receptor Protein; Receptors, Metabotropic Glutamate; Recording of previous events; Recovery; Reinforcement; Reinforcement (Psychology); Relapse; Reporting; Research; Research Personnel; Researchers; Rewards; Risk Factors; Role; Self Administration; Self-Administered; Shock; Signal Transduction; Signal Transduction Systems; Signaling; Specific qualifier value; Specified; Stimulus; Stress; Sum; Surgical; Surgical Interventions; Surgical Procedure; Susceptibility; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Therapeutic; Therapeutic Effect; Time; Training; Tranquilizing Agents, Minor; Unspecified Mental Disorder; Withdrawal; Work; addiction; antianxiety agent; approach behavior; attenuation; base; behavior test; behavioral extinction; behavioral test; biological signal transduction; c fos; c-fos Gene; c-fos Proto-Oncogenes; circulatory shock; clinical relevance; clinically relevant; cocaine exposure; cocaine prevention; cocaine relapse prevention; cocaine use; conditioning; craving; density; design; designing; disorder later incidence prevention; drug addict; drug detection; drug testing; drug/agent; effective therapy; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hedonic; hippocampal; hypocretin; hypocretin/orexin; hypocretins/orexins; improved; incentive; inducement; interest; mGlu5; meetings; mental illness; model organism; motivated behavior; neural; neural plasticity; neurobiological; neuroplasticity; novel; orexin; postsynaptic; presynaptic; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; protective effect; protein expression; psychological disorder; receptor; receptor function; reinforcer; relating to nervous system; research study; response; social role; surgery; transcription factor; trend; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog",Novel Treatments for Cocaine Dependence,,7348,NSS,,,17,423002,
7794859,R37,DA,5,,03/01/2010,02/28/2011,,5R37DA010572-15,,NIDA:480924;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN FRANCISCO,UNITED STATES,PSYCHIATRY,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"WEISNER, CONSTANCE M.;",1881451;,5R37DA010572,09/20/1996,02/28/2011,"AOD use; Abstinence; Active Follow-up; Address; Admission; Admission activity; After Care; After-Treatment; Aftercare; Age; Alcohol or Other Drugs use; Area; Arm; Caring; Catchment Area; Change of Life; Characteristics; Chemicals; Chronic; Client; Climacteric; Clinical Research; Clinical Study; Comorbidity; Costs, Medical Care; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Dependence, Substance; Dependency; Dependency (Psychology); Diagnosis; Disease; Disorder; Drug abuse; Drug abuser; Drug usage; Drugs; Effectiveness; Effects, Longterm; Electronics; Enrollment; Ensure; Epidemiology; Generalized Growth; Grant; Growth; HMO; Health Care Utilization; Health Maintenance Organizations; Health Planning; Health Services; High Prevalence; Individual; Inpatients; Intake; Interview; Length; Length of Stay; Life Style; Lifestyle; Literature; Long-Term Effects; Longitudinal Studies; Measures; Mediating; Medical; Medical Care Costs; Medication; Mental Health; Mental Hygiene; Methods and Techniques; Methods, Other; Misuses drugs; Modeling; NIDA; NIH Program Announcements; National Institute of Drug Abuse; Number of Days in Hospital; Out-patients; Outcome; Outpatients; Participant; Patient Self-Report; Patients; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Population; Prepaid Group Health Organizations; Preventive; Primary Care; Primary Health Care; Primary Healthcare; Principal Investigator; Problem drug user; Program Announcement; Psychological Health; Public Health; Randomized; Relapse; Reporting; Role; Sampling; Self-Help Groups; Self-Report; Services; Severities; Shapes; Social Functioning; Social Network; Social support; Substance Addiction; Substance abuse problem; Support Groups; System; System, LOINC Axis 4; Techniques; Time; Tissue Growth; Treatment Factor; Treatment outcome; Upper arm; Visit; Work; World Health; abuse of drugs; abuse of substances; abuses drugs; base; clinical data repository; clinical data warehouse; cohort; computerized; cost; cost effectiveness; data repository; disease/disorder; drinking; drug use; drug/agent; emotional dependency; enroll; follow-up; health care service; health care service utilization; health services utilization; healthcare service utilization; healthcare utilization; hospital days; hospital length of stay; hospital stay; indexing; inpatient service; long-term study; member; non-drug; ontogeny; prevention service; public health medicine (field); randomisation; randomization; randomly assigned; relational database; response; self help organization; service intervention; service utilization; sex; social role; social support network; substance abuse; substance use; treatment as usual; treatment effect; treatment utilization",Integrated Drug and Medical Care-Cost and Effectiveness,,10572,NSS,,,15,480924,
7776979,R37,DA,5,,02/01/2010,01/31/2011,,5R37DA010711-14,,NIDA:322703;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,SAN FRANCISCO,UNITED STATES,NONE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"VON ZASTROW, MARK E.;",1867818;,5R37DA010711,01/15/1997,01/31/2014,"APF-1; ATP-Dependent Proteolysis Factor 1; Adaptation, Physiological; Adaptations, Physiologic; Alternate Splicing; Alternative Splicing; Biochemical; Biology; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cell model; Cell surface; Cellular model; Corpus Striatum; Corpus striatum structure; Cytoplasmic Domain; Cytoplasmic Membrane; Cytoplasmic Protein; Cytoplasmic Tail; Down-Regulation; Down-Regulation (Physiology); Downregulation; Drug effect disorder; Drugs; Endocytosis; Endosomes; Event; G Protein-Complex Receptor; G-Protein-Coupled Receptors; HMG-20; High Mobility Protein 20; Intracellular Communication and Signaling; Intracellular Membranes; L-Lysine; Lysine; Lysosomes; Mediating; Medication; Membrane; Membrane Protein Traffic; Membrane Proteins; Membrane Traffic; Membrane-Associated Proteins; Modification; Molecular; NRVS-SYS; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Opiates; Opioid Receptor; Pathway interactions; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Physiological Adaptation; Plasma Membrane; Play; Population; Property; Property, LOINC Axis 2; RNA Splicing, Alternative; Receptor Gene; Receptor Protein; Receptors, Opiate; Receptors, Opioid, mu; Receptors, mu; Receptosomes; Recovery of Function; Recycling; Regulation; Role; Signal Transduction; Signal Transduction Systems; Signaling; Sorting - Cell Movement; Striate Body; Striatum; Surface Proteins; Ubiquitilation; Ubiquitin; Ubiquitination; Ubiquitinoylation; addiction; attenuation; biological signal transduction; drug action; drug/agent; functional recovery; insight; membrane structure; neuronal; novel; pathway; plasmalemma; receptor; receptor recycling; response; social role; sorting; striatal; trafficking; ubiquination; ubiquitin conjugation",MEMBRANE TRAFFICKING OF OPIOID RECEPTORS,,10711,NSS,,,14,322703,
7764732,R37,DE,5,,02/01/2010,01/31/2011,,5R37DE012354-13,,NIDCR:549632;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"ROSEN, ANTONY ;",1862489;,5R37DE012354,05/01/1998,01/31/2012,"ATGN; Affect; Antibodies; Antigens; Apoptosis; Apoptosis Pathway; Atrophic Arthritis; Attention; Autoantibodies; Autoantigens; Autoimmune; Autoimmune Process; Autologous Antigens; Biopsy; Body Tissues; C 1 Esterase; C1 Esterase; C1 s; C1s; CENP-C; CENPC protein; Cell Death, Programmed; Cessation of life; Cleaved cell; Complement 1 Esterase; Complement 1s; Complement component C1s; Cytoplasmic Granules; Data; Death; Diagnostic Findings; Disease; Disorder; Dysfunction; Effectiveness; Ensure; Epithelial Cells; Ethics Committees, Research; Experimental Designs; Functional disorder; Funding; Gland; Golgi; Golgi Apparatus; Golgi Complex; Head and Neck, Salivary Glands; Human; Human, General; IRBs; Individual; Inflammatory Arthritis; Institutional Review Boards; Laboratories; Limited Scleroderma; Lymphocyte; Lymphocytic; Man (Taxonomy); Man, Modern; Methods; Methods and Techniques; Methods, Other; Minor salivary gland structure; Muscarinic Acetylcholine Receptor; Musculoskeletal Pain Disorder; NIDR; National Institute of Dental Research; National Institute of Dental and Craniofacial Research; Oral; Pathogenesis; Pathway interactions; Patients; Phenotype; Physiopathology; Prevalence; Protocol; Protocols documentation; Reagent; Receptors, Muscarinic; Relative; Relative (related person); Reporting; Research; Research Ethics Committees; Rheumatic Diseases; Rheumatism; Rheumatoid Arthritis; Ro antigen; Ro autoantigen; Ro ribonucleoprotein; Ro-SSA antigen; Ro52 antigen; Role; SS-A antigen; Salivary; Salivary Glands; Salivary Glands, Minor; Self-Antigens; Severities; Severity of illness; Signs and Symptoms; Sjogren syndrome type A antigen; Sjogren's Syndrome; Sjogrens; Specificity; Syndrome; Techniques; Tissues; alpha, gamma brain spectrin; autoimmune antibody; centromere protein C; cleaved; clinical phenotype; cohort; cytotoxic; cytotoxic serine protease B; disease severity; disease/disorder; fodrin; fragmentin 2; granule; granzyme B; immunogen; insight; lymph cell; novel; pathophysiology; pathway; prospective; response; self reactive antibody; social role",Apoptosis in Sjogrens Syndrome,,12354,NSS,,,13,549632,
7763919,R37,DK,5,,01/01/2010,12/31/2010,PA-07-070,5R37DK017776-35,,NIDDK:438075;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"AVRUCH, JOSEPH ;",1892278;,5R37DK017776,06/01/1977,12/31/2013,"21+ years old; 5' Untranslated Regions; 5'UTR; ATP-protein phosphotransferase; Acid, Phosphatidic; Adipocytes; Adipose Cell; Adult; Affect; Amino Acids; Assay; Beta Cell; Binding; Binding (Molecular Function); Bioassay; Biogenesis; Biologic Assays; Biological Assay; Birds of Prey; Bourneville Disease; Bourneville syndrome; Bourneville-Brissaud disease; Bourneville-Pringle syndrome; Cataloging; Catalogs; Catalytic Core; Catalytic Domain; Catalytic Region; Catalytic Site; Catalytic Subunit; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Expansion; Cellular Growth; Charge; Complex; Dependence; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; EC 2.7; Elements; Epiloia; Epiloias; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FK506 binding protein 12-rapamycin associated protein 1, human; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein, human; FKBP12 Rapamycin Complex Associated Protein 1; FRAP1 protein, human; Fat Cells; GTP; GTP Phosphohydrolase Activators; GTPase Activators; Gene Transcription; General Population; General Public; Generalized Growth; Genes; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic Translation; Genetic defect; Growth; Growth and Development; Growth and Development function; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine Triphosphate; Human, Adult; Humulin R; IGF2; IGF2 gene; In Vitro; In element; Indium; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Cell; Insulin Secreting Cell; Insulin, Regular; Intermediary Metabolism; Intracellular Communication and Signaling; Kinases; Knockout Mice; L-Leucine; Leucine; Leucine, L-Isomer; Life; Lipocytes; METBL; MODY; Mammalian Cell; Maps; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Messenger RNA; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Molecular Interaction; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Muscle, Skeletal; Muscle, Voluntary; Mutation; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Novolin R; Null Mouse; Nutrient; Origin of Life; Phakomatosis, Bourneville; Phosphatidic Acid; Phosphopeptides; Phosphorylation; Phosphotransferases; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Predisposition; Pringle disease; Process; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Kinase; Protein Phosphorylation; Protein Turnover; Proteins; Quelling; RAFT1 protein, human; RAPT1 protein, human; RNA Binding; RNA Expression; RNA Interference; RNA Silencing; RNA Silencings; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins; RNAi; Rapamycin Target Protein; Raptors; Regulation; Rhabdomyosarcoma; Ribosomal Protein S6; Role; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Small G-Proteins; Small GTPases; Small Interfering RNA; Susceptibility; System; System, LOINC Axis 4; T2D; T2DM; Tissue Growth; Transcript; Transcription; Transcription, Genetic; Translational Regulation; Translations; Transphosphorylases; Tuberous Sclerosis; Type 2 diabetes; Type II diabetes; Variant; Variation; Withdrawal; Yeasts; adenoma sebaceum; adult human (21+); adult onset diabetes; aminoacid; biological signal transduction; cell growth; cerebral sclerosis; cohort; domain mapping; epiploia; fetal; gene product; genome mutation; genome-wide; glycogen synthase a kinase; hereditary multiple system hamartomatosis; human FRAP1 protein; hydroxyalkyl protein kinase; ketosis resistant diabetes; mRNA; mRNA Leader Sequences; mRNA Translation; mTOR; mTOR Inhibitor; man; man's; maturity onset diabetes; neurinomatosis centralis; neuromatosis universalis; neurospongioblastosis diffusa; novel; ontogeny; phacomatosis; phosphorylase b kinase kinase; polypeptide; protein degradation; public health relevance; rapamycin and FKBP12 target 1 protein, human; reconstitute; reconstitution; response; sclerosis tuberosa; siRNA; social role; spongioblastosis circumscripta; tuberose sclerosis",Phosphopeptide Metabolism in Adipocytes," 7. PROJECT NARRATIVE The TOR complex 1 is a protein kinase that is major determinant of the development and growth of both skeletal muscle and beta cells. We will define how insulin and the amino acid leucine jointly control the activity of TOR complex 1. We will also determine how TOR complex 1 controls the translation of RNAs that bind to the protein IMP2, variants of whose gene appear to confer susceptibility to type 2 diabetes.",17776,CADO,Cellular Aspects of Diabetes and Obesity Study Section,,35,438075,
7743590,R37,DK,5,,12/01/2009,11/30/2010,,5R37DK027619-26,,NIDDK:545020;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LOS ANGELES,UNITED STATES,PHYSIOLOGY,33,072933393,US,CA,90033,UNIVERSITY OF SOUTHERN CALIFORNIA,"BERGMAN, RICHARD NATHAN;",1880598;,5R37DK027619,02/01/1980,11/30/2011,"2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose; ACRP30 protein; AKT; Abnormal Assessment of Metabolism; Adipocytes; Adipose Cell; Adipose tissue; Akt protein; Animals; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Blood; Blood Plasma; Calories; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Signaling; Cells; Chronic Disease; Chronic Illness; Conscious; Consciousness; D-Glucose-6-phosphate phosphohydrolase; Defect; Deposit; Deposition; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Differentiation Factor, B-Cell; Disease; Disorder; Dogs; Dose; Dysfunction; Enzymes; Exhibits; Extremities; Fat Cells; Fats; Fatty Acids, Nonesterified; Fatty Tissue; Fatty acid glycerol esters; Free Fatty Acids; Functional disorder; Funding; Gastrointestinal Tract, Pancreas; Genes; Glucose-6-Phosphate Phosphohydrolase; HPGF; Hepatic; Hepatocyte-Stimulating Factor; Hour; Humulin R; Hybridoma Growth Factor; Hyperinsulinemia; Hyperinsulinism; IFN-beta 2; IFNB2; IL-1; IL-6; IL1; IL6 Protein; Individual; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Resistance; Insulin, Regular; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-6; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Limb structure; Limbs; Link; Lipids; Lipocytes; Lipolysis; Liver; Lymphocyte-Stimulating Hormone; MGI-2; MODY; Macrophage Cell Factor; Mammals, Dogs; Mature Lipocyte; Mature fat cell; Maturity-Onset Diabetes Mellitus; Measures; Metabolic Studies; Metabolic syndrome; Metabolism Studies; Modeling; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Muscle; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Myeloid Differentiation-Inducing Protein; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Non-Trunk; Nonesterified Fatty Acids; Novolin R; Obesity; Omental Fat; Omentum; Organ; Orthophosphate[{..}]oxaloacetate carboxy-lyase (phosphorylating); PAI-1; PAI1; PEPCK; PKB protein; PLANH1; Pancreas; Pancreatic; Pathogenesis; Peripheral; Peripheral Resistance; Phosphoenolpyruvate Carboxylase; Physiologic; Physiological; Physiopathology; Plasma; Plasmacytoma Growth Factor; Plasminogen Activator Inhibitor 1; Play; Protein Kinase B; Proto-Oncogene Proteins c-akt; RAC-PK protein; Relative; Relative (related person); Resistance; Resistance, Total Peripheral; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; Retroperitoneal; Retroperitoneal Cavity; Retroperitoneal Space; Retroperitoneum; Risk; Role; SNS; SRE-1 binding protein; SREBP-1; STZ; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Skeletal Muscle Tissue; Skeletal muscle structure; Societies; Source; Streptozocin; Streptozotocin; Sympathetic Nervous System; Syndrome; T Helper Factor; T2D; T2DM; Testing; Time; Triacylglycerol; Triglycerides; Type 1 Plasminogen Activator Inhibitor; Type 2 diabetes; Type II diabetes; Vascular Resistance, Systemic; Visceral; Work; Zanosar; adipocyte complement-related protein 30-kDa; adipocyte, C1q and collagen domain containing protein; adipokines; adiponectin; adipose; adiposity; adult onset diabetes; apM-1 protein; apM1 (adipose-specific) protein; base; biological signal transduction; body system, hepatic; c-akt protein; calorie (nutrition); canine; chronic disease/disorder; chronic disorder; corpulence; corpulency; corpulentia; diabetic; disease/disorder; domestic dog; glucose-6-phosphatase; insulin resistant; insulin signaling; interferon beta 2; interventional strategy; intraperitoneal; islet; ketosis resistant diabetes; lymphocyte activating factor; mRNA Expression; man; man's; maturity onset diabetes; metabolic abnormality assessment; obese; obese people; obese person; obese population; organ system, hepatic; pathophysiology; phosphoenolpyruvate carboxykinase; prevent; preventing; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; rac protein kinase; related to A and C-protein; resistant; resistin; saturated fat; social role; sterol regulatory element-binding protein 1; subcutaneous; white adipose tissue; yellow adipose tissue",Quantitative Studies of Metabolic Organ Dynamics,,27619,IPOD,Integrative Physiology of Obesity and Diabetes Study Section,,26,545020,
7749533,R37,DK,5,,12/01/2009,11/30/2010,,5R37DK030344-27,,NIDDK:346048;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,CLEVELAND,UNITED STATES,PHYSIOLOGY,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"BORON, WALTER F.;",8727520;,5R37DK030344,01/01/1982,11/30/2011,"Acid-Base Balance; Acid-Base Equilibrium; Acids; Antibodies; Autoregulation; Award; Binding; Binding (Molecular Function); Binding Sites; Brain; Cells; Choroid Plexus; Combining Site; Dependence; Disease; Disorder; Encephalon; Encephalons; Equilibrium; Evolution; Genetic Alteration; Genetic Change; Genetic defect; Health; Homeostasis; Human; Human, General; Kidney; Knockout Mice; Man (Taxonomy); Man, Modern; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Molecular Interaction; Mutation; Nervous System, Brain; Null Mouse; Oocytes; Ovocytes; Physiologic; Physiological; Physiological Homeostasis; Physiology; Play; Property; Property, LOINC Axis 2; RNA Splicing; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Renal function; Renal tubular acidosis; Roentgen Rays; Role; Side; Solutions; Splicing; Staging; Structure; Structure of choroid plexus; Testing; Urinary System, Kidney; Variant; Variation; Work; X-Radiation; X-Rays; Xrays; balance; balance function; base; disease/disorder; extracellular; genome mutation; kidney function; renal; renal tubule acidosis; social role; stoichiometry; structural biology; tool",Physiology of Electrogenic Na/HCO3 Cotransporters,,30344,NSS,,,27,346048,
7760562,R37,DK,5,,02/01/2010,01/31/2011,PA-07-070,5R37DK033209-28,,NIDDK:317666;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,TUCSON,UNITED STATES,PEDIATRICS,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"GHISHAN, FAYEZ KHALAF;",1867704;,5R37DK033209,12/01/1983,01/31/2013,"1H-Purin-6-amine; Acute; Address; Adenine; Affect; Aging; Ailmentary System; Alimentary System; Animal Model; Animal Models and Related Studies; Animal Welfare; Animals; Autoregulation; Bibliography; Binding; Binding (Molecular Function); Blood Coagulation Factor IV; Bone; Bone Density; Bone Diseases; Bone Formation; Bone Matrix; Bone Mineral Density; Bone Mineralization; Bone and Bones; Bones and Bone Tissue; CSIF; CSIF-10; Ca++ element; Calcification, Physiological; Calcium; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Chronic; Clinical; Co-Transporters; Coagulation Factor IV; Colitis; Complex; Complication; Country; Crohn's disease; Crohn's disorder; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytoplasmic Membrane; DNA Synthesis Factor; Data; Defect; Deposit; Deposition; Development; Digestive System; Digestive System (All Sites); Disease; Disorder; Distal Convoluted Tubule; Distal convoluted renal tubule structure; Down-Regulation; Down-Regulation (Physiology); Downregulation; ECGF; Ecological impact; Economic Burden; Elements; Endothelial Cell Growth Factor; Enteritis, Granulomatous; Environment; Environmental Impact; Epithelial Cells; Equilibrium; Equipment; Ethics Committees, Research; FGF; Factor IV; Fibroblast Growth Factor; Fibroblast Growth Regulatory Factor; Funding; Gastrointestinal Body System; Gene Expression; Gene Transcription; Genes; Genetic Transcription; Germ-Free; Goals; Gut Inflammation; HBGF; Health; Homeostasis; IACUC; IL-10; IL10; IL10A; IRBs; Immune; Immune Diseases; Immune Disorders; Immune Dysfunction; Immune System Diseases; Immune System Disorder; Immunologic Diseases; Immunological Diseases; Impact, Environmental; In Vitro; Inflammation Mediators; Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Diseases of the Intestinal Tract; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Inflammatory disease of the intestine; Inflammatory disorder of the intestine; Institutional Animal Care and Use Committee; Institutional Review Boards; Interleukin 10 Precursor; Interleukin-10; International; Intestinal; Intestinal Inflammation; Intestines; Intracellular Communication and Signaling; Investigators; Kidney; Kidney Tubules, Distal; Lead; Link; Lymphocyte; Lymphocytic; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Messenger RNA; Mice; Minerals; Modeling; Molecular; Molecular Interaction; Mononuclear; Murine; Mus; Names; Organ; Organ System, Gastrointestinal; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; P element; Pathogen Frees, Specific; Pathogenesis; Pathway interactions; Patients; Pb element; Phosphates; Phosphorus; Physiologic; Physiologic calcification; Physiological; Physiological Homeostasis; Plasma Membrane; Principal Investigator; Process; Productivity; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Trafficking; Proteins; Public Health; Publishing; RNA Expression; RNA, Messenger; Regulation; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resource Sharing; Resources; Role; Senescence; Series; Signal Transduction; Signal Transduction Systems; Signaling; Specific Pathogen Frees; Specificity; Testing; Traffickings, Protein; Transcription; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Ulcerated Colitis; Ulcerative Colitis; Urinary System, Kidney; Vertebrate Animals; Vertebrates; Vitamin B4; Withdrawal; abstracting; balance; balance function; base; biological signal transduction; bone; bone disorder; bone health; bone loss; bone metabolism; bowel; cytokine; design; designing; disease/disorder; eleocolitis; experiment; experimental research; experimental study; expiration; gastrointestinal system; gene product; germ free condition; granulomatous enterocolitis; health economics; heavy metal Pb; heavy metal lead; human subject; in vivo; inorganic phosphate; lymph cell; mRNA; microbial colonization; mineralization; model organism; novel; pathway; plasmalemma; prevent; preventing; programs; protein transport; public health medicine (field); regional enteritis; renal; research study; senescent; skeletal; social role; sodium phosphate; specific pathogen free; symporter; symporter (molecular); vertebrata",Development of Intestinal Transport of Ca++ and Pi,,33209,CIGP,Clinical and Integrative Gastrointestinal Pathobiology Study Section,,28,317666,
7755809,R37,DK,5,,01/01/2010,12/31/2010,,5R37DK035524-24,,NIDDK:586426;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,OAKLAND,UNITED STATES,,09,150829349,US,CA,94612,KAISER FOUNDATION RESEARCH INSTITUTE,"GLASGOW, RUSSELL E;",1866464;,5R37DK035524,09/01/1984,12/31/2011,"21+ years old; Active Follow-up; Address; Adoption; Adult; Adverse effects; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Pressure; CD-I; CDI; Care, Health; Caring; Characteristics; Chronic Disease; Chronic Illness; Communities; Compact Disc-Interactive; Compact Disk Interactive; Computers; Conditioning Therapy; Cost Effective Analyses; Cost Effectiveness Analysis; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dietary Practices; Dimensions; Distress; Drugs; Effectiveness; Effectiveness, Program; Elements; Evaluation; Generations; Glycohemoglobin A; Glycosylated hemoglobin A; Goals; Grant; Hb A1; Hb A1a+b; Hb A1c; HbA1; HbA1c; Health behavior; Health behavior change; Healthcare; Hemoglobin A(1); Human, Adult; Interactive CD; Internet; Intervention; Intervention Strategies; Life Style Modification; Link; Lipids; Literature; MODY; Maintenance; Maintenances; Maturity-Onset Diabetes Mellitus; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metric; Modeling; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Outcome; PROV; Participant; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phone; Physical activity; Prevention of relapse; Prevention strategy; Preventive; Preventive strategy; Primary Care; Primary Health Care; Primary Healthcare; Process Measure; Program Effectiveness; Programs (PT); Programs [Publication Type]; Provider; QOL; Quality of life; Randomized; Research; Research Resources; Resources; Risk; Risk Factors; Sampling; Science; Self Management; Smoking; Smoking Status; Survey Instrument; Surveys; System; System, LOINC Axis 4; T2D; T2DM; Technology; Telephone; Translating; Translatings; Translational Research; Translational Research Enterprise; Translational Science; Treatment Side Effects; Type 2 diabetes; Type II diabetes; Voice; WWW; adult human (21+); adult onset diabetes; base; behavior change; behavior intervention; behavioral intervention; cardiac disease risk; cardiac disorder risk; chronic disease/disorder; chronic disorder; cost; cost effectiveness; cost efficient analysis; design; designing; diabetes; disease risk; disorder later incidence prevention; disorder risk; drug/agent; effective intervention; effectiveness trial; efficacy research; experience; follow-up; health disparities; health disparity; health literacy; heart disease risk; heart disorder risk; hemoglobin A1c; innovate; innovation; innovative; interventional strategy; ketosis resistant diabetes; language translation; maturity onset diabetes; medication adherence; medication compliance; peer; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; primary care setting; primary outcome; programs; randomisation; randomization; randomly assigned; real world application; research to practice; response; secondary outcome; side effect; social; success; theories; therapy adverse effect; translation research enterprise; treatment adverse effect; treatment as usual; user-friendly; web; world wide web",Linking Self-Management and Primary Care for Diabetes,,35524,PRDP,Psychosocial Risk and Disease Prevention Study Section,,24,586426,
7744020,R37,DK,5,,01/01/2010,12/31/2010,,5R37DK036425-25,,NIDDK:275301;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PISCATAWAY,UNITED STATES,PATHOLOGY,06,617022384,US,NJ,088548021,UNIV OF MED/DENT NJ-R W JOHNSON MED SCH,"YURCHENCO, PETER DANA;",1873147;,5R37DK036425,01/01/1986,12/31/2012,"Address; Affect; Agonist; Apical; Architecture; Arg-Lys; Arm; Award; Back; Basement membrane; Binding; Binding (Molecular Function); Body Tissues; Cell Communication; Cell Differentiation; Cell Differentiation process; Cell Interaction; Cell surface; Cell-to-Cell Interaction; Cells; Cranin; Defect; Deposit; Deposition; Disease; Disorder; Dorsum; Dystroglycan; Dystroglycans; Embryo Development; Embryogenesis; Embryonic Development; Engineering / Architecture; Epiblast; Epithelial; Extracellular Matrix, Integrins; Funding; GFAC; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Glycoprotein GP-2; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; ILK; Integrins; Kidney; Kidney Collecting Ducts; Kidney Tubules, Collecting; Laminin; Maintenance; Maintenances; Mammals, Mice; Mediating; Mice; Modeling; Molecular Interaction; Murine; Mus; Mutation; Phase; Process; Proteins; Receptor Protein; Recombinants; Role; Signal Induction; Solid; Structure; Structure of collecting tubule; Structure-Activity Relationship; Sulfatides; Sulfatoglycosphingolipids; Sulfoglycosphingolipids; Tissues; Tubular; Tubular formation; Upper arm; Urinary System, Kidney; arginine-lysine; arginyllysine; chemical structure function; collecting tubule structure; disease/disorder; extracellular; gene product; genome mutation; implantation; integrin-linked kinase; membrane assembly; neuromuscular; p59(ILK); polymerization; receptor; renal; scaffold; scaffolding; self assembly; social role; structure function relationship; sulfated glycolipids; sulfoglycolipids",Basement Membrane Self-assembly and Structure,,36425,NSS,,,25,275301,
7760546,R37,DK,5,,02/01/2010,01/31/2011,,5R37DK036823-27,,NIDDK:363805;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,LITTLE ROCK,UNITED STATES,BIOCHEMISTRY,02,122452563,US,AR,72205,UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK,"MOCK, DONALD M;",7744031;,5R37DK036823,07/01/1985,01/31/2012,"1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-; 21+ years old; Acetyl Coenzyme A Carboxylase; Acetyl-CoA Carboxylase; Acetyl-CoA[{..}]carbon-dioxide ligase (ADP-forming); Adult; Affect; Affinity Chromatography; Alkaline Phosphatase; Amino Acid Sequence; Antibodies; Arachidonic Acids; Assay; Avidin; Bioassay; Biologic Assays; Biological Assay; Biotin; Biotinylation; Blood Plasma; Blood erythrocyte; Blood normocyte; Blood, Cord; Body Tissues; Bone Formation; Carrier Proteins; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Cell Count; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Number; Cell membrane; Cell surface; CellLine; Cells; Chromatography, Affinity; Cleft Palate; Coenzyme A, S-(hydrogen propanedioate); Custom; Cytoplasmic Membrane; DNA Content; DNA Index; DNA Ploidy; Data; Defect; Dependency; Dependency (Psychology); Development; Diet Monitoring; Dinoprostone; Drops; Egg White; Enzymes; Erythrocytes; Erythrocytic; Eukaryote; Eukaryotic Cell; Excretory function; Experimental Designs; Extremities; Fatty Acids; Fetal Activity; Fetal Movement; Fetal Skeleton; Fetus; Gel; Gene Chips; Gene Expression; Gene Expression Chip; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Gestation; Goals; Harvest; Histones; Human; Human, Adult; Human, General; Humulin R; Individual; Infant; Inpatients; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intravenous Glucose Tolerance; Intravenous Glucose Tolerance Test; Investigators; L-Leucine; Leucine; Leucine, L-Isomer; Limb Bud; Limb structure; Limbs; Literature; Lymphocyte; Lymphocytic; MCT-1; MCT-1 gene; Malonyl CoA; Malonyl Coenzyme A; Man (Taxonomy); Man, Modern; Marrow erythrocyte; Measures; Methods; Modification; Molecular; Molecular Biology, Protein Sequencing; Mutation; Nature; Non-Trunk; Novolin R; Nutrition; Nutritional Science; Orthophosphoric-monoester phosphohydrolase (alkaline optimum); Osteogenesis; Out-patients; Outpatients; PGE2; PGE2 alpha; PGE2alpha; Palate; Peptide Sequence Determination; Plasma; Plasma Membrane; Ploidies; Pregnancy; Procedures; Production; Programs (PT); Programs [Publication Type]; Progress Reports; Propionyl-CoA Carboxylase; Propionyl-Coenzyme A Carboxylase; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandins; Prostanoids; Protein Sequencing; Protein Structure, Primary; Proteins; Proteomics; RNA, Small Interfering; RT-PCR; RTPCR; Red Blood Cells; Red Cell; Red blood corpuscule; Red cell of marrow; Reports, Progress; Research; Research Personnel; Researchers; Reticuloendothelial System, Erythrocytes; Reticuloendothelial System, Serum, Plasma; Reverse Transcriptase Polymerase Chain Reaction; Role; Sampling; Science of nutrition; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Serum, Plasma; Small Interfering RNA; Staging; Staining method; Stainings; Stains; Testing; Time; TimeLine; Tissues; Transport Proteins; Transporter Protein; Umbilical Cord Blood; Vitamin H; adult human (21+); affinity purification; alkaline phosphomonoesterase; aminoacid sequence of peptide; aminoacid sequence of protein; biotin symporter; biotin transporter; biotin-binding protein; blood corpuscles; blood glucose regulation; chromosome complement; coenzyme R; cultured cell line; design; designing; dietary monitoring; emotional dependency; eukaryotida; excretion; fetal; fetal cord blood; gene product; genome mutation; glucose control; glucose homeostasis; glucose regulation; glycerophosphatase; improved; interest; intravenous glucose tolerance test; lymph cell; lymphoblast; malformation; methylmalonyl-CoA decarboxylase; monomer; mouse model; nutrition; peptide sequence; plasmalemma; programs; protein aminoacid sequence; protein sequence; response; reverse transcriptase PCR; sample collection; scale up; siRNA; social role; specimen collection; urinary; volunteer",Aspects of Biotin Nutrition,,36823,NSS,,,27,363805,
7743765,R37,DK,5,,12/01/2009,11/30/2010,,5R37DK041122-19,,NIDDK:288124;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ANN ARBOR,UNITED STATES,PHYSIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"WILLIAMS, JOHN A;",1869147;,5R37DK041122,01/01/1989,11/30/2010,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3'5'-cyclic ester of AMP; ATPase, Actin-Activated; Acetylcholine; Acinar Cell; Aciner Cells; Actins; Acute; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Triphosphatase, Myosin; Adenosine, cyclic 3',5'-(hydrogen phosphate); Apical; Area; Assimilation; Assimilations; Blood Coagulation Factor IV; CCK; Ca++ element; Calcium; Cell membrane; Cellular Matrix; Chemotherapy-Hormones/Steroids; Cholecystokinin; Coagulation Factor IV; Complex; Coupling; Cyclic AMP; Cytoplasmic Granules; Cytoplasmic Membrane; Cytoskeletal System; Cytoskeleton; Disease; Disorder; Docking; EC 2.7; Endocrine Gland Secretion; Enzymes; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Exocytosis; Factor IV; Family; Food; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Gastrointestinal Hormones; Gastrointestinal Tract, Pancreas; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Hormones; Inflammatory; Kinases; Lead; Ligands; Mediating; Membrane; Modeling; Molecular; Monomeric G-Proteins; Monomeric GTP-Binding Proteins; Movement; Myosin ATPase; Myosin Adenosinetriphosphatase; Myosins; NSF attachment protein receptor; Nerve Transmitter Substances; Neurotransmitters; Nutrient; Organ; Pancreas; Pancreatic; Pancreatic Secretion; Pancreatitis; Pancreozymin; Pb element; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Plasma Membrane; Process; Proteins; Proteomics; Public Health; Receptor Activation; Regulation; Regulatory Protein; Research; Role; SNAP receptor; SNARE; Series; Site; Small G-Proteins; Small GTPases; Stimulus; Therapeutic Hormone; Transphosphorylases; Uropancreozymin; Work; Zymogen Granules; adenosine 3'5' monophosphate; apical membrane; body movement; cAMP; disease/disorder; gene product; genetic regulatory protein; granule; heavy metal Pb; heavy metal lead; intracellular skeleton; membrane structure; myosin ATP phosphohydrolase (actin translocating); pancreatic juice; plasmalemma; public health medicine (field); regulatory gene product; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; social role; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; trafficking",Calcium and Pancreatic Stimulus-Secretion Coupling,,41122,ZRG1,Special Emphasis Panel,,19,288124,
7746357,R37,DK,5,,01/01/2010,12/31/2010,,5R37DK042495-21,,NIDDK:356400;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,BALTIMORE,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,188435911,US,MD,212011508,UNIVERSITY OF MARYLAND BALTIMORE,"PALLONE, THOMAS L;",1881269;,5R37DK042495,09/01/1990,12/31/2013,"(1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione; (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; 1-Heptanol; 1H-Benz(de)isoquinoline-2(3H)-carboxylic acid, 6-amino-1,3-dioxo-5,8-disulfo-, 2-hydrazide, dilithium salt; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 3'5'-cyclic ester of AMP; 5-Isothiocyanatofluorescein; Abscission; Acetylcholine; Acids; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine, cyclic 3',5'-(hydrogen phosphate); Adventitial Cell; Albumins; Alcohol, Heptyl; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Bathing; Baths; Blood flow; Bradykinin; Capacitance, Electrical; Carbamide; Cell Communication and Signaling; Cell Signaling; Cells; Chemicals; Communicating Junction; Communication; Confocal Microscopy; Connexins; Cyclic AMP; Cytoplasm; Deposit; Deposition; Diffusion; Dilator; Docking; Elaqua XX; Electric Capacitance; Electromagnetic, Laser; Electrophysiology; Electrophysiology (science); Endothelial Cells; Endothelium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Excision; Extirpation; FITC; FITC-dextran; Fluo 4; Fluorescein-5-isothiocyanate; Fluorescence; Fluorescent Probes; Gap Junction Proteins; Gap Junctions; Geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-; Generations; Giant Cells; Heptanol; Herbimycin; Herbimycin A; Hydrogen Oxide; IRK1 channel; Image; Image Analyses; Image Analysis; In Vitro; Injection of therapeutic agent; Injections; Injury; Instruction; Intracellular Communication and Signaling; Investigators; Inward Rectifier K+ Channels; Inwardly Rectifying Postassium Channels; Ion Channel; Ionic Channels; Ions; Isoforms; K+ Channels, Inwardly Rectifying; Kidney Medulla; L-NAME; Lasers; Letters; Low-resistance Junction; Measures; Mediating; Medullary Portion of the Kidney; Membrane Channels; Membrane Potentials; Methods; Microscopy, Confocal; Microscopy, Video; Modeling; Multinucleated Giant Cells; Muscle, Involuntary; Muscle, Smooth; N omega-Nitro-L-arginine Methyl Ester; N(G)-Nitro-L-arginine Methyl Ester; N(G)-Nitroarginine Methyl Ester; NG-Nitro-L-Arginine Methyl Ester; NG-Nitroarginine Methyl Ester; Nephrons; Neurophysiology / Electrophysiology; Nexus; Nexus Junction; Organism-Level Process; Organismal Process; Oxygen measurement, partial pressure, arterial; Peptides; Perfusion; Pericapillary Cell; Pericytes; Perivascular Cell; Permeability; Phenylephrine; Physiologic Processes; Physiologic pulse; Physiological Processes; Play; Polykaryocytes; Potassium Channels, Inwardly Rectifying; Principal Investigator; Probes, Fluorescent; Programs (PT); Programs [Publication Type]; Protein Isoforms; Protein-Tyrosine Kinases, src; Pulse; ROC Analysis; Radiation, Laser; Rectum; Regulation; Removal; Research Personnel; Researchers; Resistance; Resting Potentials; Role; Rouget Cells; Rupture; Series; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Molecule; Smooth muscle (tissue); Sodium Chloride; Sodium chloride (NaCl); Source; Structure of medulla of kidney; Study Subject; Surgical Removal; Syncytium; System; System, LOINC Axis 4; Testing; Transmembrane Potentials; Urea; Urea Carbamide; Ureaphil; Urinary System, Urine; Urine; Uriniferous Tube; Variant; Variation; Vasodilatation; Vasodilating Agent; Vasodilation; Vasodilator Agents; Vasodilator Drugs; Vasodilators; Vasorelaxation; Video Microscopy; Videomicrography; Videomicroscopy; Water; adenosine 3'5' monophosphate; arterial pO2; base; biological signal transduction; cAMP; capacitance; cell type; extracellular; fluorescein isothiocyanate dextran; fluoresceinthiocarbamoyl dextrans; image evaluation; imaging; inhibitor; inhibitor/antagonist; inward rectifier potassium channel; kallidin 9; kallidin I; kidney medulla; lucifer yellow; migration; n-Heptanol; oxygen tension; patch clamp; prevent; preventing; programs; renal medulla; resection; resistant; response; salt; social role; solute; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; wortmannin",Microvascular Transport in the Renal Medulla,,42495,NSS,,,21,356400,
7740214,R37,DK,5,,12/01/2009,11/30/2010,,5R37DK051193-15,,NIDDK:286788;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,UROLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"WANG, ZHOU ;",1861744;,5R37DK051193,12/18/1996,11/30/2010,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; AML - Acute Myeloid Leukemia; Affect; Age; Age-Months; Allelic Loss; American; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Antigens, Differentiation; Apoptosis; Apoptosis Pathway; Athymic Nude Mouse; Autoregulation; Benign Prostatic Hypertrophy; Binding; Binding (Molecular Function); Blood (Leukemia); Breeding; Cancer Model; Cancer of Prostate; CancerModel; Cancers; Carcinoma; Carcinoma of the Liver Cells; Cell Death, Programmed; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Size; Cellular Proliferation; Chromosomal dislocation; Chromosomal translocation; Collection; Common Rat Strains; Crossbreeding; Cultured Cells; Delta4-androsten-17beta-ol-3-one; Differentiation Antigens; Differentiation Markers; Disease; Disorder; Down-Regulation; Down-Regulation (Physiology); Downregulation; Dysplasia; EAF1 protein, human; ELL associated factor 1 protein, human; ELL-associated factor; ELL-associated factor, human; Epithelial; Epithelial Cell Proliferation; Epithelial Cells; Epithelial Neoplasms, Malignant; Epithelial Tumors, Malignant; Epithelium; Event; Exhibits; Foundations; Generalized Growth; Genes; Genital System, Male, Prostate; Germinoblastoma; Growth; HCC; Hepatocellular Carcinoma; Hepatocellular cancer; Hepatoma; Heterograft; Homeostasis; Human; Human Prostate; Human Prostate Gland; Human, General; Hybridization, Genetic; Hyperplasia; Hyperplasia of Prostate Gland; Hyperplastic; Induction of Apoptosis; Investigation; Investigators; Knock-out; Knockout; Knockout Mice; L-Lysine; Leukemia, Myelocytic, Acute; Leukemias, General; Loss of Heterozygosity; Lung Adenocarcinoma; Lymphoma; Lymphoma (Hodgkin's and Non-Hodgkin's); Lymphoma, Malignant; Lysine; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Marker Antigens; Markers, Differentation; Mice; Mice, Athymic; Mice, Knock-out; Mice, Knockout; Mice, Nude; Mice, Transgenic; Molecular; Molecular Interaction; Murine; Mus; Myeloblastic Leukemia, Acute; Myelogenous Leukemia, Acute; Names; Nude Mice; Null Mouse; Organ; Pathogenesis; Pathway interactions; Physiologic; Physiological; Physiological Homeostasis; Play; Prevention; Primary carcinoma of the liver cells; Programs (PT); Programs [Publication Type]; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostate Neoplasms; Prostatic Cancer; Prostatic Gland; Prostatic Hyperplasia; Prostatic Hyperplasia, Benign; Prostatic Hypertrophy, Benign; Prostatic Neoplasia; Prostatic Neoplasms; Prostatic hypertrophy; Rat; Rattus; Research; Research Personnel; Research Specimen; Researchers; Reticulolymphosarcoma; Role; Sarcoma, Germinoblastic; Specimen; Testing; Testosterone; Therapeutic Androgen; Therapeutic Testosterone; Tissue Growth; Trans-Testosterone; Transfection; Transgenic Mice; Translocation, Genetic; Transplantation, Heterologous; Tumor Suppression; Tumor Suppression, Molecular; Tumor Suppressor Proteins; Tumor of the Prostate; Wild Type Mouse; Xenograft; Xenograft procedure; Xenotransplantation; acute granulocytic leukemia; acute myeloid leukemia; acute nonlymphocytic leukemia; base; benign prostate hyperplasia; cancer cell; cancer initiation; chromosome dislocation; chromosome translocation; disease/disorder; dyscrasia; eleven nineteen lysine-rich leukemia gene-associated factor 1 protein, human; epithelial carcinoma; human EAF1 protein; in vivo; insight; knockout gene; leukemia; malignancy; men; men's; mouse model; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; overexpression; pathway; programs; prostate hyperplasia; social role; tumor growth; tumor suppressor",Role of U19/Eaf2 in androgen-dependent prostate homeostasis,,51193,UKGD,Urologic and Kidney Development and Genitourinary Diseases Study Section,,15,286788,
7764798,R37,DK,5,,02/01/2010,01/31/2011,,5R37DK054824-11,,NIDDK:276685;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,INTERNAL MEDICINE/MEDICINE,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"BIRDER, LORI A;",1909106;,5R37DK054824,02/15/1999,01/31/2012,"(1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-; 8-Methyl-N-Vanillyl-6-Nonenamide; ATP Receptors; Abbreviations; Acetic Acids; Acetylcholine; Acute; Address; Affect; Age; Agents, Muscarinic; Agonist; Apical; Area; Atropine; Attention; Autocrine Systems; Benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester endo-(+-)-; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-; Bladder; Bladder Dysfunction; Bladder Transitional Cell; Bladder Transitional Cell Epithelium; Bladder Urothelial Cell; Bladder Urothelium; Bladder mucosa; Body Tissues; Botulin; Botulinum Toxins; CTX; CYCLO-cell; Calcium Oscillations; Capsaicin; Carloxan; Cell Communication; Cell Communication and Signaling; Cell Function; Cell Interaction; Cell Process; Cell Signaling; Cell Surface Receptors; Cell physiology; Cell surface; Cell to Cell Communication and Signaling; Cell-Cell Signaling; Cell-to-Cell Interaction; Cells; Cellular Function; Cellular Physiology; Cellular Process; Characteristics; Chemicals; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; Clinical Management; Clinical Trials; Clinical Trials, Unspecified; Clostridium botulinum Toxins; Co-culture; Cocultivation; Coculture; Coculture Techniques; Collaborations; Coloring Agents; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Common Rat Strains; Communicating Junction; Communication; Complex; Coupled; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamide; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cystitis; Cytophosphan; Cytophosphane; Cytoxan; Data; Detection; Dinoprostone; Dyes; E-Mail; EC 2.7; Editorial Comment; Editorial Comment (PT); Electronic Mail; Email; Endogenous Nitrate Vasodilator; Endothelium-Derived Relaxing Factor; Endoxan; Endoxana; Enduxan; Epithelial; Epithelial Cells; Epoprostenol; Equipment; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Euler-Gaddum Substance P; Evaluation; Event; Exhibits; Exocytosis; Experimental Designs; FOS gene; Floor; Fluorescence Agents; Fluorescent Agents; Fluorescent Dyes; Fosfaseron; Funding; Future; G0S7; Ganglionic Blockaders; Ganglionic Blockers; Ganglionic Blocking Agents; Ganglioplegic Agents; Gap Junctions; Genoxal; Genuxal; Goals; Guidelines; Heterogeneity, Population; Hour; INFLM; Image; Imaging Procedures; Imaging Techniques; In Vitro; Inflammation; Injury; Intracellular Communication and Signaling; Investigators; Ion Channel; Ionic Channels; Kinases; Laboratories; Lead; Ledoxina; Light; Link; Location; Low-resistance Junction; Lower urinary tract; Mammals, Mice; Mammals, Rats; Maps; Mecamylamine; Mechanical Stimulation; Mechanics; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Membrane; Membrane Channels; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Mice; Minor; Mitoxan; Molecular; Mononitrogen Monoxide; Morphology; Movement; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinics; Myelopathy, Traumatic; NK2; NKA; NKNA; NRVS-SYS; Neosar; Nerve; Nerve Cells; Nerve Fibers; Nerve Growth Factors; Nerve Unit; Nervous; Nervous System; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neuronotrophic Factors; Neurons; Neurotrophic Factors; Neurotrophic Proteins; Neurotrophins; Nexus; Nexus Junction; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nociception; PGE2; PGE2 alpha; PGE2alpha; PGI2; PGX; PPADS; Paper; Pathology; Pathway interactions; Pb element; Permeability; Persons; Pharmacology; Phone; Phosphotransferases; Photoradiation; Physical environment; Physiologic; Physiological; Play; Population; Population Heterogeneity; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Principal Investigator; Procytox; Productivity; Programs (PT); Programs [Publication Type]; Progress Reports; Property; Property, LOINC Axis 2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostaglandin E2; Prostaglandin E2 alpha; Prostaglandin E2alpha; Prostaglandin I(2); Prostaglandin I2; Proteins; Protooncogene FOS; Published Comment; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNA, Small Interfering; RNAi; Rat; Rattus; Reader; Reading; Receptor Cell; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Receptors, Cell Surface; Receptors, Muscarinic; Recycling; Reports, Progress; Research; Research Activity; Research Personnel; Researchers; Response to stimulus physiology; Role; SP(1-11); Sampling; Scheme; Sendoxan; Sensory; Sequence-Specific Posttranscriptional Gene Silencing; Series; Signal Transduction; Signal Transduction Systems; Signaling; Small Interfering RNA; Spinal Cord Trauma; Spinal Cord transection injury; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Stiefel Brand of Capsaicin; Stimulus; Stretching; Structure; Subcellular Process; Substance P; Suggestion; Syklofosfamid; TAC1; TAC1 gene; TAC2; TRPV1; TRPV1 gene; TXT; Technics, Imaging; Techniques; Telephone; Text; Time; Tissue Sample; Tissues; Toxin; Transducers; Transections, Spinal Cord; Translating; Translatings; Transphosphorylases; Urinary System, Bladder; Urothelial Cell; Urothelium; VESCL; Vesicle; Viewpoint; Viewpoint (PT); Waves, Calcium; Work; Writing; Zytoxan; autocrine; biological signal transduction; body movement; c fos; c-fos Gene; c-fos Proto-Oncogenes; cell type; cellular targeting; chemical addition; chemical release; clinical investigation; desensitization; detector; diverse populations; dl-Hyoscyamine; endothelial cell derived relaxing factor; environmental change; experiment; experimental research; experimental study; extracellular; fluorescent dye/probe; gene product; heavy metal Pb; heavy metal lead; heterogeneous population; imaging; imaging modality; insight; intercellular communication; interdisciplinary approach; intravesical; language translation; loris; membrane structure; neural; neurokinin 1; neuronal; nociceptive; novel; optic imaging; optical imaging; patch clamp; pathway; programs; prostaglandin X; protein function; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; receptor; relating to nervous system; research study; response; sensor; sensory mechanism; sex; siRNA; social role; spelling; stimulus/response; urinary bladder; urinary bladder epithelium; v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog; wortmannin",Nitric Oxide in Bladder Neural-Epithelial Signaling,,54824,ZRG1,Special Emphasis Panel,,11,276685,
7763797,R37,EB,5,,02/01/2010,01/31/2011,,5R37EB000803-19,,NIBIB:538559;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,TUCSON,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"BARRETT, HARRISON H;",1885546;,5R37EB000803,07/01/1990,01/31/2012,"Medical Imaging, Single Photon Emission Computed Tomography; Radionuclide Tomography, Single-Photon Emission-Computed; SPECT; SPECT imaging; Tomography, Emission-Computed, Single-Photon; parallel computation; parallel computing",SPECT Imaging and Parallel Computing,,803,DMG,Diagnostic Imaging Study Section,,19,538559,
7762799,R37,EB,5,,02/01/2010,01/31/2011,PA-07-070,5R37EB003320-13,,NIBIB:409516;,2010,NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING,,ANN ARBOR,UNITED STATES,CHEMISTRY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"KENNEDY, ROBERT T;",1959646;,5R37EB003320,05/05/1999,01/31/2013,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; Aacidexam; Acute; Addiction, Drug; Adexone; Aknichthol Dexa; Alba-Dex; Alin; Alin Depot; Alin Oftalmico; Ambene; Amino Acids; Amphetamines; Amplidermis; Anemul mono; Animal Welfare; Antimicotico; Aquapred; Arts; Assay; Auxiloson; Azona; Baycuten; Baycuten N; Behavior; Behavioral; Bibliography; Bioassay; Biologic Assays; Biological Assay; Blood capillaries; Body Tissues; Brain; Brain Chemistry; Brain region; Capillaries; Capillary; Capillary, Unspecified; Cell Communication and Signaling; Cell Signaling; Cells; Chemical Dependence; Chemicals; Chromatography, Gas-Liquid-Mass Spectrometry; Circadian Rhythms; Common Rat Strains; Communities; Complex; Corson; Cortidexason; Cortisumman; Country; Coupled; Coupling; Cues; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dekacort; Deltafluorene; Dependence, Drug; Deronil; Desamethasone; Desameton; Detection; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Disease; Disorder; Diurnal Rhythm; Dopamine; Drug Addiction; Drug Dependency; Ecological impact; Electrophoresis; Encephalon; Encephalons; Endorphins; Enkephalins; Environment; Environmental Impact; Equipment; Ethics Committees, Research; FK 506; FK506; Feeding behaviors; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Fractionation, Electrophoretic; GC MS; GCMS; Gammacorten; Generations; Glia; Glial Cells; Gliosis; Goals; Hexadecadrol; Hexadrol; Hour; HuB219; Human; Human, General; Hydroxytyramine; IACUC; IRBs; Immunoassay; Immunosuppressants; Immunosuppressive Agents; Impact, Environmental; Ingestive Behavior; Injection of therapeutic agent; Injections; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Kolliker's reticulum; LEP-R; LEPR; LEPR Protein; Learning; Leptin; Lokalison-F; Loverine; Mammals, Rats; Man (Taxonomy); Man, Modern; Mass Fragmentographies; Mass Fragmentography; Measurement; Medical Imaging, Positron Emission Tomography; Methods; Methylfluorprednisolone; Microdialysis; Microfluidic; Microfluidics; Millicorten; Modeling; Monitor; Mymethasone; Names; Nerve Cells; Nerve Tissue; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Nervous Tissue; Neural Cell; Neurochemistry; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neuroglia; Neuroglial Cells; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neurons; Neuropeptides; Neurosciences; Neurosciences Research; Neurotensin; Neurotransmitters; Nicotine; Non-neuronal cell; Nyctohemeral Rhythm; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Ocasa; Oils; Opiate Peptides; Opioid Peptide; Orgadrone; PET; PET Scan; PET imaging; PETSCAN; PETT; Peptides; Phenotype; Physiologic pulse; Positron Emission Tomography Scan; Positron-Emission Tomography; Predni-F; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Principal Investigator; Problem Solving; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Pulse; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Rad.-PET; Rat; Rattus; Reaction; Receptor Protein; Recovery; Research; Research Ethics Committees; Research Resources; Resolution; Resources; Rewards; Role; Sampling; Scheme; Science of neurochemistry; Signal Transduction; Signal Transduction Systems; Signaling; Spectrometry, Mass-Gas Chromatography; Spectrum Analysis, Mass-Gas Chromatography; Spersadex; Spersadox; Stream; System; System, LOINC Axis 4; Systems Analyses; Systems Analysis; Technology; Testing; Time; Tissues; Twenty-Four Hour Rhythm; Vertebrate Animals; Vertebrates; Visumetazone; Work; abstracting; abused drugs; addiction; aminoacid; aqueous; auricularum; base; biological signal transduction; capillary; capillary liquid chromatography; circadian; circadian process; daily biorhythm; disease/disorder; diurnal variation; drug of abuse; drugs abused; drugs of abuse; experiment; experimental research; experimental study; expiration; feeding-related behaviors; human subject; immunosuppressive; improved; in vivo; interest; interventional strategy; ion trap mass spectrometry; leptin receptor; leptin-binding protein; mass fragmentometry; miniaturize; nerve cement; neural; neurochemistry; neurodegenerative illness; neuronal; neurotransmitter release; neurotrophic factor; neurotrophin; neutrophin; novel; nutrient intake activity; ob/ob mouse; prevent; preventing; programs; psychostimulant; receptor; relating to nervous system; research study; social role; tool; vertebrata",In vivo chemical monitoring using capillary separations,,3320,EBT,Enabling Bioanalytical and Biophysical Technologies Study Section,,13,409516,
7747960,R37,GM,5,,01/01/2010,12/31/2010,,5R37GM034557-27,,NIGMS:670898;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,,14,064931884,US,NY,10065,SLOAN-KETTERING INSTITUTE FOR CANCER RES,"MARIANS, KENNETH J;",1891824;,5R37GM034557,07/01/1984,12/31/2010,"Assay; Bacteria; Bioassay; Biochemical Pathway; Biologic Assays; Biological Assay; Cancers; Characteristics; DNA Helicases; DNA Recombination; DNA Unwinding Proteins; DNA recombination (naturally occurring); DNA unwinding enzyme; Double Strand Break Repair; Eukaryota; Eukaryote; Event; FLR; Failure (biologic function); Genetic Alteration; Genetic Change; Genetic Recombination; Genetic defect; Goals; Grant; Homologous Recombinational Repair; Malignant Neoplasms; Malignant Tumor; Metabolic Networks; Mutation; Nature; Pathway interactions; Predisposition; Prokaryotae; Prokaryotic Cells; Proteins; Recombination; Recombination Repair; Recombination, Genetic; Susceptibility; Syndrome; base; design; designing; eukaryotida; failure; gene product; genome mutation; helicase; malignancy; neoplasm/cancer; pathway; prokaryote; recombinational repair; repair; repaired; response; single molecule",MECHANISMS OF DNA REPLICATION,,34557,NSS,,,27,670898,
7751204,R37,GM,5,,01/01/2010,12/31/2010,,5R37GM041049-22,,NIGMS:422212;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LA JOLLA,UNITED STATES,,53,781613492,US,CA,920371000,SCRIPPS RESEARCH INSTITUTE,"GOODIN, DAVID B.;",1882807;,5R37GM041049,01/01/1989,12/31/2010,"6-DEB hydroxylase; 6-DET-hydroxylase; 6-deoxyerythronolide B hydroxylase; Abscission; Active Sites; Adamantane; Affinity; Amino Acids; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Antibodies; Arachidonic Acids; Architecture; Attention; Bacteriophages; Behavior; Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-; Binding; Binding (Molecular Function); Binding Sites; Biological Models; CYP; CYP101; CYP107A1; CYPCVIIA1; Camphor; Camphor 5-Monooxygenase; Catalysis; Characteristics; Chemicals; Chemistry; Combining Site; Complex; Crystallography, X-Ray; Crystallography, X-Ray Diffraction; Crystallography, X-Ray/Neutron; Crystallography, Xray; Cytochrome P-450; Cytochrome P-450 101; Cytochrome P-450 Enzyme System; Cytochrome P-450(cam); Cytochrome P450; Cytochrome P450(cam); Cytochrome c Peroxidase; Cytochromes; Development; Diamantane; Distal; Engineering; Engineering / Architecture; Engineerings; Environment; Enzymes; Evolution; Excision; Exhibits; Extirpation; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferrocytochrome c[{..}]hydrogen-peroxide oxidoreductase; Ferroprotoporphyrin; Filamentous Bacteriophages; Funding; Goals; Heme; Heme Proteins; Heme b; Hemeproteins; Humanities; Hydroxylases; In Vitro; Inovirus; Investigators; Learning; Libraries; Ligand Binding; Ligands; Methods; Miscellaneous Antibiotic; Mixed Function Oxidases; Mixed Function Oxygenases; Model System; Modeling; Models, Biologic; Molecular Interaction; Mono-S; MonoS; Monooxygenases; Oxygenases; P450; P450cam; P450eryF; Phage Display; Phages; Phase; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Conformation; Proteins; Protoheme; Protoheme IX; Randomized; Reaction; Reactive Site; Recruitment Activity; Removal; Research Personnel; Researchers; Role; Route; Scaffolding Protein; Scheme; Science of Chemistry; Side; Single Crystal Diffraction; Site; Sites, Active; Specific qualifier value; Specificity; Specified; Structure; Substrate Specificity; Surface; Surgical Removal; System; System, LOINC Axis 4; Testing; Tricyclo(3.3.1.1(3,7))decane; Variant; Variation; Work; X Ray Crystallographies; X-Ray Crystallography; aminoacid; bacterial virus; base; catalyst; chemical reaction; chemical synthesis; cofactor; cytochrome P-450 CYP107A1; cytochrome P450eryF; directed evolution; drug candidate; erythomycin A biosynthesis hydrolase; falls; ferroheme; flexibility; gene product; hemoprotein; insight; mutant; nitrophorin 1; novel; oxidation; programs; protein structure; randomisation; randomization; randomly assigned; recruit; resection; scaffold; scaffolding; small molecule; social role",Novel Substrate Oxidation by Enzyme Engineering,,41049,MSFA,Macromolecular Structure and Function A Study Section,,22,422212,
7744649,R37,GM,5,,01/01/2010,12/31/2010,,5R37GM043214-20,,NIGMS:716025;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CAMBRIDGE,UNITED STATES,CHEMISTRY,08,082359691,US,MA,02138,HARVARD UNIVERSITY,"JACOBSEN, ERIC N;",1883872;,5R37GM043214,01/01/1991,12/31/2011,"Binding Sites; C element; Carbon; Catalysis; Coin; Combining Site; Complex; Development; Epoxides; Epoxy Compounds; Generations; Grant; Hand; Imines; Investigation; Lead; Ligands; Metals; Nature; Organic Synthesis; Pb element; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Prevalence; Programs (PT); Programs [Publication Type]; Public Health; Reaction; Reactive Site; Research; Screening procedure; Synthesis Chemistry; Synthetic Chemistry; System; System, LOINC Axis 4; Transition Elements; base; catalyst; design; designing; heavy metal Pb; heavy metal lead; programs; public health medicine (field); screening; screenings; transition metal",Chiral Catalysts Designed to Catalyze Organic Reactions,,43214,NSS,,,20,716025,
7758201,R37,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R37GM046904-20,,NIGMS:359719;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW HAVEN,UNITED STATES,BIOCHEMISTRY,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HOCHSTRASSER, MARK ;",1905686;,5R37GM046904,02/01/1992,01/31/2014,"20S Catalytic Proteasome; 20S Core Proteasome; 20S Proteasome; 20S Proteosome; APF-1; ATP-Dependent Proteolysis Factor 1; Active Follow-up; Address; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Area; Assay; Bears; Behavior; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological; Biological Assay; Cancers; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cells; Chaperone; Closure by Ligation; Complex; Coupled; Cystic Fibrosis; Cytosol; DNA Binding; DNA Binding Interaction; Defect; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E3 Ligase; E3 Ubiquitin Ligase; ER-associated degradation Pathway; ERAD; Endoplasmic Reticulum; Endoplasmic Reticulum Degradation Pathway; Enzymes; Ergastoplasm; Eukaryota; Eukaryote; Generalized Growth; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genetics-Mutagenesis; Genomics; Goals; Growth; HMG-20; High Mobility Protein 20; Homeo Domain; Human; Human, General; Idiopathic Parkinson Disease; In Vitro; Integral Membrane Protein; Intracellular Communication and Signaling; Intrinsic Membrane Protein; Lewy Body Parkinson Disease; Life; Ligase; Ligation; Macropain; Macroxyproteinase; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Membrane; Methods; Modeling; Molecular Biology, Mutagenesis; Molecular Chaperones; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mucoviscidosis; Multicatalytic Proteinase; Mutagenesis; Mutation; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Nuclear; Nuclear Envelope; Nuclear Membrane; Nuclear Protein; Nuclear Proteins; Nucleus; Ortholog; Orthologous Gene; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Pathway interactions; Patients; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Prosome; Proteasome; Proteasome Endopeptidase Complex; Protein Cleavage; Proteins; Proteolysis; Proteomics; Proteosome; Quality Control; Regulatory Protein; Research; Role; S cerevisiae; Saccharomyces cerevisiae; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Structure; Synthetases; System; System, LOINC Axis 4; Temperature; Tissue Growth; Transcription Corepressor; Transcription Repressor; Transcription Repressor/Corepressor; Transcriptional Corepressor; Transcriptional Repressor; Transcriptional Repressor/Corepressor; Transmembrane Protein; Ubiquitilation; Ubiquitin; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligase E3; Ubiquitination; Ubiquitinoylation; Ursidae; Ursidae Family; Viral; Work; Yeast, Baker's; Yeast, Brewer's; Yeasts; aberrant protein folding; abnormal protein folding; biological signal transduction; cofactor; dementia of the Alzheimer type; diabetes; disease/disorder; eukaryotida; experiment; experimental research; experimental study; follow-up; gene product; genetic regulatory protein; genome mutation; homeodomain; intervention development; malignancy; membrane structure; multicatalytic endopeptidase complex; mutant; neoplasm/cancer; neurodegenerative illness; ontogeny; pathologic protein folding; pathway; primary degenerative dementia; protein complex; protein mis-folding; protein misfolding; prototype; public health relevance; regulatory gene product; research study; senile dementia of the Alzheimer type; social role; therapy development; transcription factor; treatment development; ubiquination; ubiquitin conjugation; ubiquitin ligase; ubiquitin-protein ligase",Degradation of Short Lived Regulatory Protein in Yeast," A small protein called ubiquitin regulates the growth and behavior of all human cells; ubiquitin is attached to specific cell proteins, and this directs these proteins to a large protein complex that then degrades them. Defects in the enzymes controlling these processes are known to cause neurodegenerative disorders, developmental abnormalities, and various cancers. This project aims to deepen our understanding of the enzymes that attach ubiquitin to damaged proteins as well as to important regulatory proteins, with the long-term goal of developing therapies to treat patients suffering from Alzheimer's disease, diabetes, cancer and other diseases.",46904,MBPP,Membrane Biology and Protein Processing Study Section,,20,359719,
7751303,R37,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R37GM048405-18,,NIGMS:398648;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"KINGSTON, ROBERT ;",1897803;,5R37GM048405,01/01/1993,12/31/2013,"Antisera; Applications Grants; Binding Proteins; CHIP assay; Cancers; Cataloging; Catalogs; Cell Nucleus; Cells; ChIP (chromatin immunoprecipitation); Chromatin; Chromatin Remodeling Complex; Chromatin Remodeling Factor; Chromatin Structure; Communicable Diseases; DNA; DNA Recombination; DNA Sequence; DNA recombination (naturally occurring); Deoxyribonucleic Acid; Development; Digestion; Disease; Disorder; Emergent Technologies; Emerging Technologies; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Flooding; Floods; Gene Expression; Gene Transcription; Genes; Genetic Recombination; Genetic Transcription; Genome; Genome, Human; Genomics; Grant Proposals; Grants, Applications; Histones; Human; Human Genome; Human, General; ISWI; ISWI protein; Imitation Switch; Immune Sera; In Vitro; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Ligand Binding Protein; Location; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Methods and Techniques; Methods, Other; Modeling; Modification; Molecular; Nature; Normal Cell; Nucleosomes; Nucleus; Play; Population; Position; Positioning Attribute; Process; Proteins; RNA Expression; RNA-Binding Proteins; Recombination; Recombination, Genetic; Regulation; Role; Staining method; Stainings; Stains; Structure; T-Cells; T-Lymphocyte; Techniques; Technology; Testing; Thymus-Dependent Lymphocytes; Transcription; Transcription, Genetic; Variant; Variation; Viral Diseases; Virus Diseases; base; cell type; chromatin immunoprecipitation; design; designing; disease/disorder; experiment; experimental research; experimental study; gene product; histone modification; in vivo; malignancy; neoplasm/cancer; public health relevance; research study; social role; telomere; thymus derived lymphocyte; transcription factor; viral infection; virus infection",Transcription Factor Interactions with Nucleosomes," Project Narrative:  Epigenetic mechanisms impact the expression of the human genome by altering the ability of individual genes to be expressed in different cell types, and are known to contribute strongly to normal development and to many disease processes including cancer. These mechanisms rely in large part upon mechanisms to modify chromatin structure, the focus of this grant application. This application proposes experiments to understand how human chromatin structure might be regulated to effect changes in gene expression and as such is directly relevant to an understanding of numerous disease processes from cancer to infectious disease.",48405,NDT,Nuclear Dynamics and Transport,,18,398648,
7756599,R37,GM,5,,01/01/2010,12/31/2010,,5R37GM053256-17,,NIGMS:322156;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,PATHOLOGY,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"KORETZKY, GARY A.;",6068510;,5R37GM053256,01/01/1995,12/31/2010,"ARAM; ATP[{..}]protein-tyrosine O-phosphotransferase; Abscission; Address; Adhesions; Ag Recognition Activation Motif; Amino Acids; Animals; Antigen Receptors; Binding; Binding (Molecular Function); Binding Sites; Biochemical; Blood Vessels; Blood leukocyte; C-terminal; Cell Communication and Signaling; Cell Death; Cell Function; Cell Line; Cell Lines, Strains; Cell Maturation; Cell Process; Cell Signaling; Cell Survival; Cell Viability; Cell physiology; CellLine; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cellularity; Co-Stimulator; Combining Site; Complex; Costimulator; Critical Paths; Critical Pathways; Cytosol; Defect; Development; Disease; Disorder; EC 2.7; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Elements; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Epidermal Thymocyte Activating Factor; Event; Excision; Exclusion; Extirpation; Extracellular Matrix, Integrins; Funding; Gel; GeneHomolog; Generations; Genes; Goals; Grant; HEK3; Hematopoietic; Homolog; Homologous Gene; Homologue; Human; Human, General; IL-2; IL2; IL2 Protein; ITAM; Immune; Immune response; Immune system; Immunoreceptor Tyr-Based Activation Motif; Immunoreceptor Tyrosine-Based Activation Motif; Integrin Signaling Pathway; Integrins; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-2; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Intracellular Communication and Signaling; Investigators; Jurkat Cells; Kinases; Knock-in; Knock-in Mouse; Knockout Mice; L-Tyrosine; LTK; LTK protein, human; Learning; Lecithinases; Leukocyte Tyrosine Kinase; Leukocyte Tyrosine Kinase Receptor; Leukocytes; Location; Lymphocyte Mitogenic Factor; MHC Receptor; Major Histocompatibility Complex Receptor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mature T-Cell; Mature T-Lymphocyte; Mediating; Memory; Mice; Mice, Knock-out; Mice, Knockout; Mitogenic Factor; Modeling; Molecular Genetic; Molecular Genetics; Molecular Interaction; Movement; Murine; Mus; Myelogenous; Myeloid; N-terminal; NH2-terminal; Normal Cell; Null Mouse; PTK; Pathologic; Pathway interactions; Peptides; Peripheral; Phospholipase; Phosphoproteins; Phosphotransferases; Process; Programs (PT); Programs [Publication Type]; Proline-Rich Domain; Proline-Rich Region; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein Tyrosine Kinase-1; Proteins; Reactive Site; Receptor Protein; Receptor Signaling; Receptors, Antigen; Receptors, Antigen, T-Cell; Regulatory T-Lymphocyte; Removal; Reporter; Research Personnel; Researchers; Reticuloendothelial System, Leukocytes; Reticuloendothelial System, Thymus; Retinoic Acid Receptor; Role; SH2 Domains; SH3 Domains; SRC Homology Region 3 Domain; Series; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Site; Staging; Stimulus; Structure; Subcellular Process; Surface; Surgical Removal; T cell growth factor; T-Cell Activation; T-Cell Development; T-Cell Growth Factor; T-Cell Ontogeny; T-Cell Receptor; T-Cell Stimulating Factor; T-Cell Subsets; T-Cells; T-Lymphocyte; T-Lymphocyte Development; T-Lymphocyte Subsets; T-Lymphocyte, Regulatory; TYR; Testing; Therapeutic; Thymocyte Development; Thymocyte Stimulating Factor; Thymus; Thymus Gland; Thymus Proper; Thymus-Dependent Lymphocytes; Time; Transgenic Organisms; Translating; Translatings; Transphosphorylases; Tyrosine; Tyrosine Kinase; Tyrosine, L-isomer; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Variant; Variation; Vav guanine-nucleotide exchange factor; White Blood Cells; White Cell; Work; adapter protein; aminoacid; biological signal transduction; body movement; body system, allergic/immunologic; combat; cultured cell line; disease/disorder; experiment; experimental research; experimental study; gene product; host response; human LTK protein; hydroxyaryl protein kinase; immunoresponse; in vivo; inhibitor; inhibitor/antagonist; insight; intermolecular interaction; language translation; leukocyte tyrosine kinase protein, human; loss of function; mutant; necrocytosis; novel; organ system, allergic/immunologic; overexpression; para-Tyrosine; pathway; prevent; preventing; programs; receptor; receptor binding; receptor-mediated signaling; reconstitute; reconstitution; research study; resection; response; social role; src Homology Region 2 Domain; thymocyte; thymus derived lymphocyte; trafficking; transgenic; tyrosyl protein kinase; vascular; white blood cell; white blood corpuscle",Novel substrates of the TCR kinase,,53256,CMI,Cellular and Molecular Immunology - A,,17,322156,
7746455,R37,GM,5,,02/01/2010,01/31/2011,PA-07-070,5R37GM055382-16,,NIGMS:446717;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,CHAMPAIGN,UNITED STATES,CHEMISTRY,15,041544081,US,IL,61820,UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN,"HARTWIG, JOHN F;",1867196;,5R37GM055382,02/01/1999,01/31/2014,"1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-; Acids; Adopted; Air; Alcohols; Alkanesulfonates; Alkenes; Alkyl Sulfonates; Alkylsulfonate Compound; Amides; Amination; Amines; Ammonia; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antihypertensive Agents; Antihypertensive Drugs; Antihypertensives; Antiinflammatories; Antiinflammatory Agents; Aromatic Amines; Arylamines; Aspiration, Respiratory; Azoles; Biological Factors; Breathing; C element; Carbamates; Carbohydrate Chemistry; Carbon; Chemical Class, Alcohol; Chemistry; Chemistry, Pharmaceutical; Chloride; Chloride Ion; Chlorides; Cl- element; Complex; Copper; Coupling; Cu element; Data; Development; Drug Discovery Groups; Drugs; Electrons; Equilibrium; Esters; Ethers; Experimental Designs; Factor, Biologic; Foundations; Future; Generations; Grant; H element; HDL; Health; Heavy Lipoproteins; High Density Lipoproteins; High density lipoprotein; Human; Human, General; Hydrogen; Hydrogen Bonding; Hypotensive Agent; Hypotensive Drugs; Hypotensives; Imidates; Individual; Inhalation; Inhaling; Inspiration, Respiratory; Ir element; Iridium; Kinetic; Kinetics; Lanthanides; Lanthanoid Series Elements; Lanthanoids; Lead; Ligands; Lipoproteins, HDL; Man (Taxonomy); Man, Modern; Medication; Medicinal Chemistry; Mercaptans; Mercapto Compounds; Metals; Method LOINC Axis 6; Methodology; Methods; Modification; N element; N2 element; Natural Products; Negative Beta Particle; Negatrons; Nitrogen; Nucleic Acids; O element; O2 element; Olefins; Organic Synthesis; Organometallic Chemistry; Oxygen; Palladium; Pathway interactions; Pb element; Pd element; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Process; Programs (PT); Programs [Publication Type]; Publishing; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reaction; Reagent; Reflux; Relative; Relative (related person); Research; Research Support; Rest; Rh element; Rhodium; Roentgen Rays; Route; S element; Science of Chemistry; Series; Sertraline; Spinal Column; Spine; Sulfhydryl Compounds; Sulfides; Sulfur; System; System, LOINC Axis 4; Temperature; Thiols; Vertebral column; Work; X-Radiation; X-Rays; Xrays; Zoloft; alpha-Lipoproteins; aryl halide; backbone; balance; balance function; base; catalyst; design; designing; drug candidate; drug discovery; drug/agent; experiment; experimental research; experimental study; functional group; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; insight; inspiration; meetings; next generation; pathway; piperidine; programs; public health relevance; research study; sulfhydryl group; sulfonate; tool; torcetrapib","Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S"," Project Narrative Some of the catalysts that have resulted from this project dramatically improve methods to prepare pharmaceutical intermediates and new catalysts that will result from the proposed research promise to be equally important for the synthesis of these and other biologically active materials. Thus, successful development of the proposed research will significantly increase the accessibility of compounds that improve human health.",55382,SBCB,Synthetic and Biological Chemistry B Study Section,,16,446717,
7750521,R37,GM,5,,01/01/2010,12/31/2010,PA-07-070,5R37GM060398-11,,NIGMS:301102;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,BIOCHEMISTRY,30,092530369,US,CA,90095,UNIVERSITY OF CALIFORNIA LOS ANGELES,"JACOBSEN, STEVEN E;",1900854;,5R37GM060398,01/01/2000,12/31/2013,"2(1H)-Pyrimidinone, 4-amino-; Adopted; Alleles; Allelomorphs; Animal Model; Animal Models and Related Studies; Anti-Oncogenes; Antioncogenes; Arabidopsis; Arabidopsis thaliana; Assay; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological Assay; Body Tissues; C elegans; C.elegans; Caenorhabditis elegans; Cancer Biology; Cancer Cause; Cancer Etiology; Chemicals; Chromatin; Chromosomes; Cress, Mouse-ear; Cytosine; DNA; DNA Methylation; DNA Methyltransferase; DNA Modification Methylases; DNA Modification Methyltransferases; DNA Sequence; DNA-Binding Proteins; DNA-Methyltransferases; Defect; Deoxyribonucleic Acid; Developmental Biology; Dnmt; Drosophila; Drosophila genus; EC 2.1.1; EC 2.1.1.113; Emerogenes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Eukaryota; Eukaryote; Feedback; Fruit Fly, Drosophila; Gene Action Regulation; Gene Expression Regulation; Gene Inactivation; Gene Regulation; Gene Regulation Process; Gene Silencing; GeneHomolog; Generations; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Regulator; Genetic; Genetic Alteration; Genetic Change; Genetic Imprinting; Genetic Screening; Genetic analyses; Genetic defect; Genetic screening method; Genome; Genomic Imprinting; Genomics; Grant; Histone H3; Histones; Homolog; Homologous Gene; Homologue; Hypermethylation; Inverted Repeat Sequences; Lead; Light; Lyonization; Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Methods; Methylation; Methyltransferase; Modification; Modification Methylases; Molecular Genetic; Molecular Genetics; Molecular Interaction; Mouse-ear Cress; Mutation; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Organism; Parental Imprinting; Pattern; Pb element; Photoradiation; Plant Model; Plants; Plants, General; Play; Process; Protein Methylation; Proteins; RNA, Small Interfering; Recruitment Activity; Regulator Genes; Repeat Sequences, Inverted; Research; Role; Series; Site; Site-Specific DNA-methyltransferase; Small Interfering RNA; Small RNA; Specificity; Study models; System; System, LOINC Axis 4; Tissues; Transcriptional Regulatory Elements; Tumor Suppressing Genes; Tumor Suppressor Genes; Work; X Inactivation; X-Chromosome Inactivation; Yeasts; abstracting; demethylation; eukaryotida; experiment; experimental research; experimental study; fruit fly; gene function; gene product; genetic analysis; genetic testing; genome mutation; genome-wide; heavy metal Pb; heavy metal lead; histone H3 methyltransferase; histone methylase; histone methyltransferase; human disease; imprint; insight; interest; living system; loss of function; methylase; model organism; mutant; oncosuppressor gene; positional cloning; prevent; preventing; public health relevance; recruit; regulatory gene; research study; reverse genetics; siRNA; social role; tool; trans acting element; transmethylase; tumor",Genetics of DNA methylation patterning of arabidopsis.," Project Narrative This research aims at understanding the basic mechanisms that control DNA methylation, which is a chemical modification that occurs on certain genes and prevents these genes from functioning in a particular tissue. When DNA methylation patterns are not properly maintained, this can cause inappropriate regulation of genes and is a major cause of cancer. Thus a further understanding of the DNA methylation may someday lead to methods for correcting DNA methylation patterning defects.",60398,MGB,Molecular Genetics B Study Section,,11,301102,
7760667,R37,HL,5,,02/01/2010,01/31/2011,,5R37HL087062-04,,NHLBI:420000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PHARMACOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"GROSS, STEVEN S;",7098524;,5R37HL087062,02/01/2007,01/31/2012,"2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-; 5,6,7,8-tetrahydrobiopterin; 7,8-dihydrobiopterin; Affinity; Amputation; Animal Model; Animal Models and Related Studies; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; BH4; BP control; BPH4; Basic Research; Basic Science; Binding; Binding (Molecular Function); Biopterin; Blindness; Blood Vessels; Body Tissues; Bovine Species; CNOS; Cattle; Cell Communication and Signaling; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cessation of life; Chronic; Complications of Diabetes Mellitus; Constitutive NOS; D-Glucose; Death; Development; Dextrose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diabetes-Related Complications; Diabetic Complications; Diffusion; Drug Therapy; Dysfunction; EC 1.14.13.39; ECNOS; EDRF Synthase; ENOS; Electron Transport; Endogenous Nitrate Vasodilator; Endopeptidase K; Endothelial Cells; Endothelial NOS; Endothelial Nitric Oxide Synthase; Endothelial Nitric Oxide Synthase 3; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Engineering; Engineerings; Equilibrium; Exhibits; Face; Functional disorder; Generations; Genetic Models; Glucose; Goals; Golgi; Golgi Apparatus; Golgi Complex; Guanylyl Cyclase-Activating Factor Synthase; H4B; H4biopterin; Health; Hyperglycemia; Intracellular Communication and Signaling; Isoforms; Kidney Diseases; Kidney Failure; Kidney Insufficiency; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); L-erythro-dihydrobiopterin; L-erythro-q-dihydrobiopterin; Lesion; MODY; Mammals, Mice; Maturity-Onset Diabetes Mellitus; Measurement; Mediating; Membrane; Mice; Mitochondria; Modeling; Models, Genetic; Modification; Molecular; Molecular Interaction; Mononitrogen Monoxide; Murine; Mus; NADPH-Diaphorase; NIDDM; NO Synthase; NOS Type III; NOS3; NOS3 protein, human; NOSIII; Nephropathy; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase 3; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Oxidants; Oxidizing Agents; Parents; Pathogenesis; Peptides; Peroxonitrite; Peroxonitrites; Peroxynitrites; Pharmacotherapy; Physiologic; Physiological; Physiopathology; Play; Position; Positioning Attribute; Production; Protease K; Protein Isoforms; Proteinase K; Proteins; Proteomics; Ramp; Reaction; Regulation; Relative; Relative (related person); Renal Disease; Renal Failure; Renal Insufficiency; Renal function; Reporting; Research; Role; SKIL; SKIL gene; SNO; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Stress; Superoxide Anion; Superoxide Radical; Superoxides; T2D; T2DM; THBP; Testing; Tissues; Translations; Tritirachium Alkaline Proteinase; Type 2 diabetes; Type II diabetes; Vascular Diseases; Vascular Disorder; Vascular Endothelial Cell; adult onset diabetes; aminoacid sequence of peptide; aminoacid sequence of protein; balance; balance function; base; biological signal transduction; blood pressure control; blood pressure homeostasis; blood pressure regulation; blood vessel disorder; bovid; bovine; cofactor; cow; cultured cell line; diabetes; diabetes mellitus therapy; diabetes therapy; diabetic; dihydrobiopterin; eNOS enzyme; electron acceptor; electron transfer; endothelial cell derived relaxing factor; endothelial constitutive nitric oxide synthase; experiment; experimental research; experimental study; facial; feeding; gene product; human NOS3 protein; hyperglycemic; ketosis resistant diabetes; kidney disorder; kidney function; maturity onset diabetes; membrane structure; mitochondrial; model organism; novel; oxidation; pathophysiology; peptide sequence; peroxynitrite; premature; protein aminoacid sequence; protein protein interaction; q-BH2; quinonoid dihydrobiopterin; renal disorder; research study; restoration; social role; tetrahydro-6-biopterin; tetrahydrobiopterin; type I and type II diabetes; vascular",Diabetic Vasculopathy and Mitochondrial eNOS,,87062,PBKD,Pathobiology of Kidney Disease Study Section,,4,420000,
7760106,R37,MH,5,,02/01/2010,01/31/2011,,5R37MH043784-21,,NIMH:750749;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,PSYCHIATRY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"LEWIS, DAVID A;",3141929;,5R37MH043784,09/30/1988,01/31/2011,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Accounting; Affect; Aminalon; Aminalone; Axon Terminals; Butanoic acid, 4-amino-; Cognitive Manifestations; Cognitive Symptoms; Dorsal; Dorsomedial Nucleus; Dorsomedial Nucleus of the Thalamus; Dorsomedial Thalamic Nucleus; Dysfunction; Functional disorder; GABA; GABA-A Receptor; Genes; Human; Human, General; Lesion; Macaca; Macaque; Man (Taxonomy); Man, Modern; Medial Dorsal Nucleus; Mediodorsal Nucleus; Mediodorsal Thalamic Nucleus; Molecular; Monkeys; Nerve Cells; Nerve Endings, Presynaptic; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neurobehavioral Manifestations; Neurocyte; Neuronal Transmission; Neurons; Pattern; Physiopathology; Prefrontal Cortex; Presynaptic Terminals; Protein Subunits; Pyramidal neuron; Receptors, GABA-Benzodiazepine; Receptors, Muscimol; Schizophrenia; Schizophrenic Disorders; Signs and Symptoms, Neurobehavioral; Specificity; Synaptic Boutons; Synaptic Terminals; Testing; Thalamic structure; Thalamus; base; dementia praecox; design; designing; gamma-Aminobutyric Acid; hippocampal pyramidal neuron; neural circuit; neural circuitry; neuronal; neurotransmission; non-human primate; nonhuman primate; pathophysiology; postsynaptic; presynaptic; schizophrenic; thalamic",GABA Neurons and Cortical Circuitry in Schizophrenia,,43784,NSS,,,21,750749,
7787487,R37,MH,5,,02/01/2010,01/31/2011,,5R37MH045361-23,,NIMH:360614;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ANN ARBOR,UNITED STATES,ANESTHESIOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"BAGHDOYAN, HELEN A;",1897438;,5R37MH045361,09/01/1989,01/31/2014,"(3-O-hexyloxy)-TZTP; 1,2-Benzenedicarboxaldehyde; 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-Mercaptoethanol; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; 3-(3-O-hexyl-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine; 4-Aminobutanoic Acid; 4-Aminobutyric Acid; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-; Accounting; Acetylcholine; Acids; Address; Adverse effects; Affect; Affective Psychosis, Bipolar; Agents, Muscarinic; Agonist; American; Aminalon; Aminalone; Amino Acids; Analytical Chemistry; Anesthesia; Anesthesia procedures; Animals; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Anxiety; Apnea; Apnea, Sleep; Area; Arousal; Arts; Aspartate; Atropine; Behavioral; Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-; Benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester endo-(+-)-; Bicuculline; Binding; Binding (Molecular Function); Bipolar Disorder; Blood capillaries; Brain; Brain Diseases; Brain Disorders; Brain region; Butanoic acid, 4-amino-; Capillaries; Capillary; Capillary Electrophoresis; Capillary, Unspecified; Cardiac artery; Cardiopulmonary; Cats; Cell Communication and Signaling; Cell Signaling; Cessation of life; Characteristics; Chemistry, Analytic; Chemistry, Analytical; Cholest-5-en-3-ol (3beta)-; Cholesterol; Cholinergic Receptors; Cholinoceptive Sites; Cholinoceptors; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chronic; Clinical; Clozapine; Cognitive; Cognitive deficits; Collecting Tube; Common Rat Strains; Coronary artery; Coupled; Data; Data Collection; Data Reporting; Death; Delta Wave; Delta Wave sleep; Depression; Detection; Development; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Dialysis; Dialysis procedure; Disease remission; Doctor of Philosophy; Domestic Cats; Drops; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drug Therapy; Drugs; Dysfunction; EEG; Electroencephalogram; Electroencephalography; Electromagnetic, Laser; Electrophoresis, Capillary; Encephalon; Encephalon Diseases; Encephalons; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Ethanesulfonic acid, 2-amino-; Ethanol, 2-mercapto-; Event; Excessive Daytime Sleepiness; Excessive daytime somnolence; Feline Species; Felis catus; Felis domestica; Felis domesticus; Felis sylvestris catus; Figs; Figs - dietary; Fluorescence; Flushing; Flushings; Fractionation, Capillary Electrophoresis; Functional disorder; Funding; Future; GABA; Generations; Genetic; Genotype; Gln; Glutamates; Glutamine; Goals; Grant; HPLC; Haldol; Haloperidol; Hcrt protein; Hcrt/ORX; Hcrts/ORXs; Health; Heart artery; High Pressure Liquid Chromatography; History; Human; Human, General; Hyperglycemia; Hyperlipemia; Hyperlipidemia; Injection of therapeutic agent; Injections; Intracellular Communication and Signaling; Intracranial CNS Disorders; Intracranial Central Nervous System Disorders; L-Aspartate; L-Glutamate; L-Glutamine; Laboratories; Lasers; Learning; Letters; Light; Link; Liquid substance; MODY; Major Tranquilizers; Mammals, Cats; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Maturity-Onset Diabetes Mellitus; Measurement; Measures; Mediating; Medication; Memory; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mental Depression; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Mentors; Mercaptoethanol; Methods; Methods and Techniques; Methods, Other; Mice; Mice, Obese; Microdialysis; Microinjections; Mission; Molecular Interaction; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinics; NIDDM; NIH; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); National Institutes of Health; National Institutes of Health (U.S.); Neostigmine; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Neural Cell; Neurochemistry; Neurocyte; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Neuromediator Receptors; Neuronal Transmission; Neurons; Neuroregulator Receptors; Neurotransmitter Receptor; Neurotransmitters; Nipecotic Acids; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obese Mice; Obesity; Orthophthaldialdehyde; Paper; Paradoxical Sleep; Patients; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Phase; Phenotype; Photoradiation; Physiopathology; Play; Pons; Pons Cerebelli; Pons Varolii; Pontine; Pontine structure; Postdoc; Postdoctoral Fellow; Prefrontal Cortex; Pressure; Pressure- physical agent; Principal Investigator; Programs (PT); Programs [Publication Type]; Proserine; Prozerin; Psyche structure; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Psychosis, Manic-Depressive; Public Health; Publishing; Pump; Q. Levoglutamide; REM Sleep; RMSN; Radiation, Laser; Ramp; Rat; Rats, Sprague-Dawley; Rattus; Receptor Protein; Receptors, ACh; Receptors, Acetylcholine; Receptors, Muscarinic; Receptors, Neurohumor; Recording of previous events; Recovery; Remission; Reporting; Reporting, Data; Research; Research Associate; Resolution; Reticular Formation; Rhombencephalic Sleep; Ringer's solution; Risk; Risk Factors; Risperidone; Rodent; Rodentia; Rodentias; Role; Sampling; Schizophrenia; Schizophrenic Disorders; Science of neurochemistry; Series; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Hypopnea; Sleep Wake Cycle; Sleep, Fast-Wave; Sleep, REM; Sleep-Disordered Breathing; Slow-Wave Sleep; Solutions; Sprague-Dawley Rats; Straight Tube; Strategic Planning; Symptoms; Synstigmin; System; System, LOINC Axis 4; T2D; T2DM; Tauphon; Taurine; Techniques; Technology; Testing; Thalamic structure; Thalamus; Time; Tranquilizing Agents, Major; Translational Research; Translational Research Enterprise; Translational Science; Transmission; Treatment Side Effects; Tube; Type 2 diabetes; Type II diabetes; United States National Institute of Mental Health; United States National Institutes of Health; Unspecified Mental Disorder; V (voltage); WHO; Wakefulness; Wakefulnesses; Weight; Weight Gain; Weight Increase; Work; World Health Organization; adiposity; adult onset diabetes; adult youth; aminoacid; atypical antipsychotic; awake; basal forebrain; biological signal transduction; bipolar affective disorder; body weight gain; body weight increase; brain research; brain size; brain tissue; capillary; cholinergic; combat; corpulence; corpulency; corpulentia; dementia praecox; dialysis therapy; dl-Hyoscyamine; dreaming sleep; drug/agent; experiment; experimental research; experimental study; fluid; gamma-Aminobutyric Acid; hyperglycemic; hypocretin; hypocretin/orexin; hypocretins/orexins; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; insight; instrument; ketosis resistant diabetes; liquid; manic depressive disorder; manic depressive illness; maturity onset diabetes; mental; mental illness; migration; neurochemistry; neuronal; neurotransmission; neurotransmitter release; new approaches; novel; novel approaches; novel strategies; novel strategy; o-Phthalaldehyde; o-Phthaldialdehyde; obese; obese people; obese person; obese population; obesity risk; olanzapine; orexin; ortho-Phthalaldehyde; ortho-Phthalic Aldehyde; pathophysiology; photomultiplier; post-doc; post-doctoral; premature; pressure; programs; psychological disorder; public health medicine (field); rapid eye movement; rapid eye movement sleep; receptor; research study; resperidone; response; schizophrenic; side effect; sleep abnormalities; sleep control; sleep problem; sleep regulation; social role; thalamic; therapy adverse effect; trait; translation research enterprise; transmission process; treatment adverse effect; uptake; voltage; wasting; working memory; wt gain; xanomeline; young adult",CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION,,45361,NSS,,,23,360614,
7777404,R37,NS,5,,02/01/2010,01/31/2011,,5R37NS025713-23,,NINDS:386134;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,CLEVELAND,UNITED STATES,NEUROSCIENCES,11,077758407,US,OH,441067015,CASE WESTERN RESERVE UNIVERSITY,"SILVER, JERRY ;",1959041;,5R37NS025713,02/01/1988,01/31/2012,"21+ years old; Adult; Affect; After Care; After-Treatment; Aftercare; Animals; Astrocytes; Astrocytus; Astroglia; Axon; Behavior; Biology; Brain; CNS Injury; Caliber; Cell Body; Cells; Central Nervous System Injury; Chondroitinases; Chronic; Cicatrix; Data; Dendrites; Diameter; Duran-Reynals Permeability Factor; Elements; Encephalon; Encephalons; Environment; Equipment; FLR; Failure (biologic function); Fiber; Fostering; GL Enzyme; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Generalized Growth; Goals; Growth; Growth Cones; Human, Adult; Hyaglosidase; Hyaluronate 4-glycanohydrolase; Hyaluronate Hydrolase; Hyaluronidase; Hyaluronoglucosaminidase; INFLM; In Vitro; Inflammation; Injection of therapeutic agent; Injections; Injury; Injury of central nervous system; Intrinsic drive; Lesion; Mediating; Medulla Spinalis; Microinjections; Modeling; Molecular; Myxoid cyst; Natural regeneration; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neural Ganglion; Neurocyte; Neurons; Pattern; Peripheral Nerves; Plant Roots; Reflex; Reflex action; Regeneration; Role; Scars; Sensory; Spinal Cord; Sterility; Testing; Time; Tissue Growth; Viral; Withdrawal; Zymosan; adult human (21+); axon regeneration; axonal regeneration; base; cell body (neuron); central nervous system injury; chondroitinase; clinical relevance; clinically relevant; combinatorial; experiment; experimental research; experimental study; failure; his-PG; in vitro Model; in vivo; neural cell body; neuronal; neuronal cell body; neurotrophic factor; neurotrophin; neutrophin; novel; ontogeny; progesterone 11-hemisuccinate-(2-iodohistamine); regenerate; research study; root; social role; soma; sterile",Factors Affecting Regeneration Through the Glial Scar,,25713,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,23,386134,
7751209,R37,NS,5,,02/01/2010,01/31/2011,PA-02-060,5R37NS028471-20,,NINDS:596223;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,STANFORD,UNITED STATES,BIOPHYSICS,14,009214214,US,CA,943056203,STANFORD UNIVERSITY,"KOBILKA, BRIAN K;",1886292;,5R37NS028471,04/01/1990,01/31/2012,"1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 1-acyl-sn-glycerol-3-phosphate; 1-oleoyl-lysophosphatidic acid; 3,4-Dihydroxyphenethylamine; 3-D structure; 3-dimensional structure; 3D structure; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; 4-(2-Aminoethyl)-1,2-benzenediol; Adrenaline; Adrenergic Receptor; Adrenoceptors; Agonist; Antibodies; Antistrumin; Arrestins; Arts; Behavior; Binding; Binding (Molecular Function); Biological Models; Catecholamines; Cells; Chemotherapy-Hormones/Steroids; Collaborations; Complex; Computer Simulation; Computerized Models; Coupling; Crystallization; Crystallographies; Crystallography; Cysteine; Detergents; Development; Dopamine; Drug Design; Drugs; Endocrine Gland Secretion; Energy Transfer; Epi; Epinephrine; FRET; Family; Fluorescein; Fluoresceins; Fluorescence Microscopy; Fluorescence Resonance Energy Transfer; G Protein-Complex Receptor; G-Protein-Coupled Receptors; G-Proteins; GTP-Binding Proteins; GTP-Regulatory Proteins; Genetics-Mutagenesis; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Half-Cystine; Hormones; Hydroxytyramine; L-Cysteine; L-Lysine; LPA; Label; Laboratories; Levarterenol; Levonorepinephrine; Ligands; Lysine; Lysophosphatidic Acids; Lysophospholipids; MOPA; Maleimides; Maps; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Membrane; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Model System; Models, Biologic; Models, Computer; Molecular Biology, Mutagenesis; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Stereochemistry; Monitor; Mutagenesis; Nerve Transmitter Substances; Neurotransmitters; Noradrenaline; Norepinephrine; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphatides; Phospholipids; Potassium Iodide; Potassium iodide (KI); Property; Property, LOINC Axis 2; Proteins; Receptor Protein; Receptors, Epinephrine; Resolution; Screening procedure; Simulation, Computer based; Site; Solutions; Spin Labels; Structure; Sympathins; Techniques; Technology; Tet; Tetanus Helper Peptide; Therapeutic Epinephrine; Therapeutic Hormone; adenoreceptor; base; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; conformation; conformational state; drug development; drug/agent; experiment; experimental research; experimental study; extracellular; fluorophore; gene product; in silico; interest; lysophosphatidic acid; member; membrane structure; monoamine; monooleylphosphatidate; monooleylphosphatidic acid; receptor; research study; screening; screenings; tetramethylrhodamine maleimide; three dimensional structure; virtual simulation",Beta2 Adrenoceptor Structure and Mechanism of Activation,,28471,MNPS,Molecular Neuropharmacology and Signaling Study Section,,20,596223,
7759223,R37,NS,5,,02/01/2010,01/31/2011,PA-07-070,5R37NS030853-18,,NINDS:572878;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,KANSAS CITY,UNITED STATES,PHYSIOLOGY,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"NUDO, RANDOLPH J;",1899710;,5R37NS030853,06/01/1993,01/31/2012,"Acquired brain injury; Apoplexy; Area; Behavior; Behavior assessment; Behavioral; Biological; Brain Injuries; CNS plasticity; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Common Rat Strains; Data; Development; Gene Expression; Grant; Infarction; Intervention; Intervention Strategies; Mammals, Rats; Maps; Methods and Techniques; Methods, Other; Molecular; Motor; Motor Cortex; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; Neuronal Plasticity; Neurons; Parietal Lobe; Parietal Lobe of the Brain; Pathway interactions; Pattern; Physiatric Procedure; Physical Medicine Procedure; Physical Therapeutics; Physical Therapy Procedure; Physical Therapy Techniques; Physical therapy; Physiotherapy; Physiotherapy (Techniques); Physiotherapy Procedure; Rat; Rattus; Recovery; Role; Science of neurophysiology; Secondary Lesion; Series; Somatosensory Cortex; Stroke; Structure; Techniques; Time; Training; Vascular Accident, Brain; Work; behavioral assessment; brain attack; brain damage; brain lesion (from injury); cerebral vascular accident; experience; experiment; experimental research; experimental study; frontal cortex; frontal lobe; improved; infarct; insight; interventional strategy; neural plasticity; neuronal; neurophysiology; neuroplasticity; non-human primate; nonhuman primate; novel; parietal cortex; pathway; post stroke; poststroke; research study; social role; somesthetic sensory cortex; stroke; stroke recovery",Reorganization of motor cortex following brain injury,,30853,CND,Clinical Neuroscience and Disease Study Section,,18,572878,
7743567,R37,NS,5,,01/01/2010,12/31/2010,,5R37NS035165-15,,NINDS:438408;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,BALTIMORE,UNITED STATES,NEUROSCIENCES,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"KOLODKIN, ALEX L;",1901891;,5R37NS035165,05/01/1996,12/31/2011,"3'5'-cyclic ester of AMP; A kinase anchoring protein; AKAP; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Award; B2 antigen, Xenopus; C 1 Esterase; C1 Esterase; C1 s; C1s; Cancers; Cell Communication and Signaling; Cell Signaling; Cellular Matrix; Clinical; Complement 1 Esterase; Complement 1s; Complement component C1s; Complex; Cues; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotides; Cytoplasmic Protein; Cytoskeletal System; Cytoskeleton; Development; Drosophila; Drosophila genus; Environment; Event; Family; Fruit Fly, Drosophila; Funding; Genes; Genetic Screening; Goals; Growth Cones; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Immune system; Individual; Injury; Intracellular Communication and Signaling; Intracellular Second Messengers; Invertebrata; Invertebrates; Invertebrates, General; Investigators; Link; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Mammals, Rodents; Mediating; Membrane; Motor; Nerve Cells; Nerve Unit; Neural Cell; Neural Development; Neurocyte; Neurons; Nucleotides, Cyclic; PKA; Play; Process; Protein Family; Protein Kinase A; Proteins; Receptor Protein; Regulation; Research Personnel; Researchers; Rodent; Rodentia; Rodentias; Role; Second Messenger Systems; Second Messengers; Semaphorins; Signal Transduction; Signal Transduction Systems; Signaling; Work; adenosine 3'5' monophosphate; axon growth cone guidance; axon guidance; biological signal transduction; body system, allergic/immunologic; cAMP; cAMP-Dependent Protein Kinases; cGMP; experiment; experimental research; experimental study; extracellular; fruit fly; gene product; guanosine 3'5' monophosphate; in vivo; insight; intracellular skeleton; malignancy; membrane structure; neoplasm/cancer; neurodevelopment; neuronal; neuronal growth; neuronal guidance; novel; organ system, allergic/immunologic; plexin; receptor; research study; response; scaffold; scaffolding; second messenger; social role",Semaphorin-Mediated Neuronal Growth Cone Guidance,,35165,NDPR,"Neurodifferentiation, Plasticity, and Regeneration Study Section",,15,438408,
7778362,R41,DE,5,,03/01/2010,02/28/2011,PA-06-008,5R41DE019335-02,,NIDCR:171844;,2010,NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH,,BIRMINGHAM,UNITED STATES,,07,105914159,US,AL,352031821,"VISTA ENGINEERING, INC.","THOMPSON, RAYMOND G.;",9316195;,5R41DE019335,03/01/2009,02/28/2011,"Adhesions; Affect; Air; Alloys; Applications Grants; Architecture; Arthroplasty, Replacement; Articulation; Arts; Biological; Biomedical Engineering; Body Tissues; Brain; Chemical Engineering; Chemicals; Clinical; Co element; Cobalt; Collaborations; Collection; Common Rat Strains; Couples; Dental; Deposit; Deposition; Deterioration; Development; Device Designs; Devices; Diamond; Dimensions; Disease; Disorder; Ear; Ear structure; Elements; Encephalon; Encephalons; Engineering; Engineering / Architecture; Engineerings; Ethene Homopolymers; Ethylene Homopolymers; Ethylene Polymers; Eye; Eyeball; FLR; Failure (biologic function); Fixation; Fossa; Friction; Grant; Grant Proposals; Grants, Applications; Implant; Industry; Jaw Joint; Joint Prosthesis; Joint Prosthesis Implantation; Joints; Lead; Legal patent; Licensing; Load-Bearing; Loadbearing; Mammals, Rats; Mandibular joint; Masticatory muscles; Mechanics; Medical; Metals; Methods; Miniature Swine; Minipigs; Modeling; Muscle of the Mastication; NIH Program Announcements; Nanoscale Science; Nanotechnology; Nerve; Nervous; Nervous System, Brain; Operation; Operative Procedures; Operative Surgical Procedures; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Osseointegration; Osteolysis; Outcome Study; Pain; Painful; Particulate; Patents; Pathway interactions; Patients; Pb element; Performance; Phase; Polyethylenes; Process; Program Announcement; Property; Property, LOINC Axis 2; Prosthesis; Prosthetic device; Prosthetics; Rat; Rattus; Reaction; Recurrence; Recurrent; Replacement Arthroplasty; Research; Resistance; Route; Shapes; Structure; Study, Outcome; Surface; Surgical; Surgical Interventions; Surgical Procedure; Swine, Miniature; Symptoms; TMJ; TMJ Diseases; TMJ Disorders; TMJD; Technology; Temporo-mandibular joint disorder; Temporomandibular Disorders; Temporomandibular Joint; Temporomandibular Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular joint disorder; Testing; Ti element; Tissues; Titanium; United States; Weight-Bearing; Weight-Bearing state; Weightbearing; base; bioengineering; bioengineering/biomedical engineering; biomedical implant; commercial application; commercialization; design; designing; disease/disorder; failure; heavy metal Pb; heavy metal lead; implant device; implantable device; implantation; improved; in vivo; indwelling device; joint replacement; mini pig; nano; nano scale Science; nano structured; nano tech; nano technology; nanostructured; nanotech; novel; pathway; public health relevance; resistant; response; restoration; sample fixation; scale up; simulation; success; surgery; technological innovation; tool; vapor",Nanotechnology Enabled Temporomandibular Joint (TMJ) Prosthesis," Project Narrative  We propose the use of nanotechnology approaches for controlling interfaces between Temporomandibular Joint (TMJ) implants and the surrounding tissues. It is estimated that more than 10 million people suffer from the TMJ-related disorder symptoms in the Unites States alone. The primary focus of this grant application is to improve the fixation, durability and osseointegration for long-term success of TMJ implants and lower the need for recurrent multiple surgical procedures. Also, development of new nanotechnology tools and methods will lead to a new class of functionalized nanostructured surfaces for titanium and cobalt chrome alloys for use in biomedical implant industry. One benefit of the diamond-diamond components will be reductions in overall device size that will ultimately allow for a clinically less-invasive route to joint restoration and longer implant lifetime in vivo. We also propose a clear pathway for commercialization of the nanotechnology enabled TMJ prosthesis.",19335,ZRG1,Special Emphasis Panel,,2,171844,
7765502,R42,DA,5,,01/31/2010,01/30/2011,PA-07-281,5R42DA021455-04,,NIDA:400286;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,Langhorne,UNITED STATES,,08,143621105,US,PA,19047,"POLARIS HEALTH DIRECTIONS, INC.","BOUDREAUX, EDWIN D;",7366422;,5R42DA021455,04/01/2006,01/30/2011,"AOD use; Abstinence; Abuse Reporting; Accident and Emergency department; Address; Administrator; Adopted; Advisory Committees; Alcohol or Other Drugs use; Alcohols; Ambulatory Care Facilities; American; American Medical Association; Anxiety; Articulation; Auditory; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Businesses; Cardiology; Cardiovascular Disease (Specialty); Care, Health; Caring; Centers for Medicare and Medicaid Services; Centers for Medicare and Medicaid Services (U.S.); Characteristics; Chemical Class, Alcohol; Clinical; Clinical Services; Codes, CPT; Computer Hardware; Computer Programs; Computer software; Conditioning Therapy; Cost Savings; Counseling; Critiques; Current Procedural Terminology Codes; Data; Decision Making; Depression; Detection; Development; Development and Research; Documentation; Domestic Violence; Drug Evaluation, Preclinical; Drug Screening; Drug abuse; Drug usage; Drugs; Drugs, Illicit; Education; Educational aspects; Effectiveness; Electronic Health Record; Electronics; Emergencies; Emergency Department; Emergency Medicine; Emergency Situation; Emergency room; Enrollment; Evaluation; Evaluation Studies; Evaluation Studies, Drug, Pre-Clinical; Evaluation Studies, Drug, Preclinical; Evidence based practice; Exercise; Exercise, Physical; Family Practice; Fax; Federal Government; Feedback; Foundations; Frequencies (time pattern); Frequency; Generations; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Health; Health Care Costs; Health Care Financing Administration; Health Care Financing Administration (U.S.); Health Care Providers; Health Care Utilization; Health Costs; Health Insurance for Aged and Disabled, Title 18; Health Insurance for Aged, Title 18; Health Insurance for Disabled Title 18; Health Personnel; Health behavior; Healthcare; Healthcare Costs; Healthcare Providers; Healthcare worker; Healthy People 2010; Human; Human, General; Illicit Drugs; Individual; Inpatients; Insurance; Insurance Coverage; Insurance Status; Internet; Intervention; Intervention Strategies; Interview; Investments; JCAHO; Joint Commission on Accreditation of Healthcare Organizations; Joint Commission on Accreditation, Health Care Organizations; Joints; Killings; Laboratories; Lead; Letters; Libraries; Life Style Modification; Link; Man (Taxonomy); Man, Modern; Marketing; MeSH Descriptors Class 4; Medical; Medical Specialities; Medicare; Medication; Mental Depression; Mental Health; Mental Hygiene; Methods; Modeling; Morbidity; Morbidity - disease rate; Motivation; National Committee for Quality Assurance; National Government; On-Line Systems; Online Systems; Out-patients; Outcome; Outpatient Clinics; Outpatients; PROV; Patients; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Physicians; Preclinical Drug Evaluation; Premature Mortality; Preparedness; Preventive; Printing; Process; Programs (PT); Programs [Publication Type]; Provider; Psychiatrist; Psychological Health; Psychologist; Public Health; R & D; R&D; Readiness; Recommendation; Registries; Reporting; Reporting, Abuse; Research; Research Institute; Research Resources; Resources; SCHED; STTR; Saving, Cost; Schedule; Schools, Medical; Screening procedure; Self-Administered; Services; Site; Small Business Technology Transfer Research; Software; Specialties, Medical; Specialty; Substance abuse problem; Summary Reports; System; System, LOINC Axis 4; Task Forces; Telefacsimile; Telefax; Test Result; Testing; Title 18; Tobacco; United States; United States Centers for Medicare and Medicaid Services; United States Health Care Financing Administration; Update; Victimization; Visit; WWW; Wireless Technology; Wood; Wood material; Work; abuse of drugs; abuse of substances; abuses drugs; alcohol and other drug; base; behavior intervention; behavioral intervention; clinical care; commercialization; computer program/software; computer system hardware; computerized; design; designing; drug use; drug/agent; enroll; falls; family medicine; flexibility; geographic site; health care personnel; health care service utilization; health care worker; health insurance for disabled; health provider; health services utilization; healthcare personnel; healthcare service utilization; healthcare utilization; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interest; interventional strategy; medical personnel; medical schools; medical specialties; online computer; programs; psychosocial; public health medicine (field); public health relevance; research and development; response; screening; screening and brief intervention; screening, brief intervention, referral, and treatment; screenings; self help; substance abuse; substance use; tobacco abuse; tool; treatment as usual; treatment provider; treatment response; treatment utilization; ward; web; web based; wireless; world wide web",Dynamic Assessment and Referral System for Substance Abuse (DARSSA) Phase 2,,21455,ZRG1,Special Emphasis Panel,,4,400286,
7763167,R42,HL,5,,02/01/2010,01/31/2011,PA-08-051,5R42HL083531-03,,NHLBI:420475;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,Tucker,UNITED STATES,,06,361719755,US,GA,30084,EXPRESSION THERAPEUTICS,"DOERING, CHRISTOPHER BRADLEY (contact);SPENCER, H TRENT;",1943684;2127597 (contact);,5R42HL083531,11/01/2005,01/31/2011,"A Mouse; Affect; Anabolism; Animal Model; Animal Models and Related Studies; Animal Testing; Animals; Antihemophilic Factor; Arthropathies NOS; Articulation; Arts; Bleeding; Blood Clot; Blood Clotting; Blood Coagulation Factor VIII; Blood Plasma; Blood Precursor Cell; Blood Proteins; Blood coagulation; Blood-coagulation factor VIII, complex; CD34; CD34 gene; Canine Species; Canis familiaris; Cell Line; Cell Lines, Strains; CellLine; Cells; Chaperone; Clinical; Clinical Trials; Clinical Trials, Phase I; Clinical Trials, Unspecified; Coagulation Factor VIII; Coagulation Factor VIIIc; Complementary DNA; Cyclic GMP; DNA Alteration; DNA mutation; DNA, Complementary; Development; Disease; Disorder; Dogs; Drip Infusions; Drip, Intravenous; Drugs, Investigational; Early-Stage Clinical Trials; Effectiveness; Elements; Endoplasmic Reticulum; Ergastoplasm; Evaluation Research; F8 protein, human; F8B protein, human; FVIII protein, human; Factor VIII; Factor VIII Deficiency; Factor VIII F8B; Family suidae; Gene Alteration; Gene Copy Number; Gene Dosage; Gene Mutation; Gene Transfer; Gene Transfer Clinical; Gene Transfer Procedure; Gene-Tx; Genes; Genetic Intervention; Genetic mutation; Goals; Guanosine Cyclic 3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine, cyclic 3',5'-(hydrogen phosphate); Guidelines; HPCA1; HSC transplantation; Hematopoietic; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hemophilia; Hemophilia A; Hemophilia As; Hemorrhage; Human; Human, General; Hybrids; IV Infusion; Immune response; In Vitro; Individual; Infusion; Infusion procedures; Infusions, Intravenous; Intervention, Genetic; Intravenous infusion procedures; Investigational Drugs; Investigational New Drugs; Joint Diseases; Joints; Laboratories; Lead; Lentiviral Vector; Lentivirus Vector; Mammals, Dogs; Mammals, Mice; Man (Taxonomy); Man, Modern; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Methods; Mice; Mission; Modification; Molecular Biology, Gene Therapy; Molecular Chaperones; Morbidity; Morbidity - disease rate; Murine; Mus; NOD/SCID mouse; New Drug Approvals; Outcome; Patients; Pb element; Phase; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Pigs; Plasma; Plasma Proteins; Procoagulant Component; Production; Progenitor Cells, Hematopoietic; Property; Property, LOINC Axis 2; Recombinants; Regimen; Research; Research, Evaluation; Reticuloendothelial System, Serum, Plasma; STTR; Sequence Alteration; Serum, Plasma; Small Business Technology Transfer Research; Suidae; Swine; Technology; Testing; Therapeutic; Therapy, DNA; Thromboplastinogen; Toxicology; Transgenes; Transplantation; Treatment Efficacy; Universities; Viral Vector; antihemophilic factor A; arthropathic; arthropathies; base; biosynthesis; blood loss; cDNA; cGMP; canine; clinical efficacy; clinical investigation; clinical relevance; clinically relevant; coagulation factor VIII, procoagulant component (hemophilia A) protein, human; conditioning; cost; cultured cell line; design; designing; disease/disorder; domestic dog; factor VIII, human; gene therapy; gene therapy clinical trial; genetic therapy; genetically modified cells; guanosine 3'5' monophosphate; heavy metal Pb; heavy metal lead; host response; human F8 protein; immunoresponse; improved; in vivo; inhibitor; inhibitor/antagonist; joint disorder; model organism; mouse model; phase 1 study; phase 1 trial; phase I trial; platelet cofactor I; porcine; pre-clinical; preclinical; preclinical study; protocol, phase I; public health relevance; rFVIII; recombinant antihemophilic factor VIII; recombinant factor VIII; recombinant virus; reconstitute; reconstitution; standard care; suid; therapeutic efficacy; therapeutically effective; thromboplastinogen A; transfer of a gene; transplant; vector",Ex Vivo Gene Therapy for Hemophilia A," PROJECT NARRATIVE Current treatment for hemophilia A, which is a bleeding disorder caused by genetic mutations affecting a blood protein, termed factor VIII (fVIII), relies on infusion of plasma-derived or recombinant fVIII to restore circulating fVIII activity. This therapy is extremely expensive and difficult to maintain, and is, therefore, only offered to 30% of hemophilia A patients worldwide. Gene therapy can cure the disease and this proposal focuses on overcoming the obstacles that limit successful gene therapy for hemophilia A.",83531,ZRG1,Special Emphasis Panel,,3,420475,
7761206,R43,AI,5,,02/01/2010,01/31/2011,PA-08-001,5R43AI081531-02,,NIAID:288512;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Madison,UNITED STATES,,50,199748000,US,WI,53719,"BIOSENTINEL, LLC","TUCKER, WARD C;",3081256;,5R43AI081531,02/01/2009,01/31/2011,"Accounting; Activity Cycles; Adverse Experience; Adverse event; Animals; Antibodies; Assay; B blood cells; B-Cells; B-Lymphocytes; Bacteria; Bacterial Toxins; Bioassay; Biologic Assays; Biological; Biological Assay; Biological Terrorism; Bioterrorism; Blepharospasm; Bontoxilysin; Botulinum A Toxin; Botulinum Neurotoxin A; Botulinum Toxin Type A; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Categories; Cell Isolation; Cell Line; Cell Lines, Strains; Cell Segregation; Cell Separation; Cell Separation Technology; CellLine; Cells; Cervical Dystonia; Cessation of life; Characteristics; Chemicals; Cleaved cell; Clinical; Clostridium; Clostridium Botulinum Toxin Type A; Clostridium botulinum A Toxin; Clostridium botulinum B toxin; Collaborations; Cosmetics; Cranial Nerve VII Diseases; Cranial Nerve VII Disorders; Cytoplasm; Cytosol; DOD; Death; Department of Defense; Detection; Development; Development and Research; Devices; Diagnostic; Disease; Disorder; Disorder of muscle, unspecified; Energy Transfer; Engineering; Engineerings; Esteroproteases; Evaluation; Event; FDA approved; FLR; Facial Nerve Diseases; Facial Nerve Disorders; Facial Neuropathy; Failure (biologic function); Fluorescence; Fluorescence Microscopy; Generalized Growth; Goals; Government; Growth; Half-Life; Half-Lifes; Hand; Health; High Throughput Assay; Human; Human, General; In Vitro; Industry; Infection; Intoxication; Investigators; Lead; Letters; Life; Mammals, Mice; Man (Taxonomy); Man, Modern; Marketing; Measures; Medical Research; Methods; Mice; Microscopy, Fluorescence; Microscopy, Light, Fluorescence; Monitor; Murine; Mus; Muscle Cell Contraction; Muscle Contraction; Muscle Disease; Muscle Disorders; Muscle Tension; Muscle disease or syndrome; Muscular Contraction; Muscular Diseases; Muscular Tension; Myopathic Conditions; Myopathic Diseases and Syndromes; Myopathic disease or syndrome; Myopathy; Myopathy, unspecified; N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive fusion protein; N-ethylmaleimide-sensitive protein; NEM-sensitive fusion protein; NRVS-SYS; NSF attachment protein receptor; Nerve Cells; Nerve Unit; Nervous System; Nervous system structure; Neural Cell; Neuroblastoma; Neuroblastoma (Schwannian Stroma-Poor); Neurocyte; Neuroendocrine; Neuroendocrine System; Neurologic; Neurologic Body System; Neurologic Organ System; Neurological; Neurons; Neurosecretory Systems; Pain; Painful; Pb element; Peptidases; Peptide Hydrolases; Performance; Persons; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Poisoning; Poisons; Preparation; Pressure; Pressure- physical agent; Process; Production; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Quality Control; R & D; R&D; Reader; Receptor Cell; Receptor Protein; Reporter; Reporting; Research; Research Institute; Research Personnel; Research, Medical; Researchers; Respiratory Failure; SNAP receptor; SNARE; Screening procedure; Serotyping; Seventh Cranial Nerve Diseases; Specificity; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Time; Tissue Growth; Toxic Chemical; Toxic Substance; Toxin; Training; Universities; VESCL; Validation; Vesicle; Wisconsin; Work; base; botulinum B toxin; botulinum neurotoxin; botulinum neurotoxin B; botulinum toxin type B; cell engineering; cell sorting; cellular engineering; cleaved; conventional therapy; cosmetic product; cultured cell line; disease/disorder; emergency service personnel; emergency service responder; emergency service/first responder; failure; first responder; fluorescence imaging; fluorophore; gene product; heavy metal Pb; heavy metal lead; high throughput screening; improved; in vivo; instrument; meetings; muscular disorder; neuronal; neurotoxin receptor; neurotransmitter release; next generation; novel; ontogeny; overexpression; poison; poisoned; pressure; public health relevance; receptor; receptor binding; receptor expression; receptor function; research and development; respiratory insufficiency/failure; screening; screenings; soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; stable cell line; success; toxic compound; uptake",A Cell-based Assay for Botulinum Neurotoxin Detection and Development," Project Narrative Botulinum neurotoxins are extremely lethal bacterial toxins that attack the nervous system and are considered a significant bioterrorism threat. Botulinum neurotoxins are also widely used for cosmetic and pharmaceutical applications providing relief of muscle contraction and pain. BioSentinel proposes to develop a high-throughput assay for measuring botulinum neurotoxin activity in living cells, providing a much needed platform for screening antagonists to BoNT and developing new BoNT-based therapies.",81531,ZRG1,Special Emphasis Panel,,2,288512,
7768469,R43,AI,5,,02/01/2010,01/31/2011,PA-06-134,5R43AI082799-02,,NIAID:313028;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,,03,158864715,US,MA,01605,"MICROBIOTIX, INC","BOWLIN, TERRY L;",8018767;,5R43AI082799,02/11/2009,01/31/2011,"1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine; 1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine; 2'-Nor-2'-deoxyguanosine; 2'NDG; 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 21+ years old; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-; 9-((2-Hydroxyethoxy)methyl)guanine; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; AIDS Dementia; AIDS Dementia Complex; AIDS with dementia; AIDS-related dementia; ATP[{..}]thymidine 5'-phosphotransferase; Acicloftal; Aclovir; Acquired Immune Deficiency Syndrome related dementia; Acycloguanosine; Acyclovir; Adult; Animals; Antiviral Agents; Antiviral Drugs; Antivirals; Bone Marrow; Burkitt Herpesvirus; Burkitt Lymphoma Virus; CMV; Carcinoma of Nasopharynx; Cargosil; Cells; Chemicals; Chemistry, Pharmaceutical; Chicken Pox; Chickenpox; Chickenpox Virus; Childhood; Cidofovir; Clinical; Clinical Research; Clinical Study; Clinical, Transplantation, Organ; Communicable Diseases, Emerging; Cytomegalovirus; DHPG; DNA Polymerases; DNA Sequence; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Data; Dementia Complex, AIDS-Related; Dementia Complex, Acquired Immune Deficiency Syndrome; Dementia Due to HIV Disease; Dementia associated with AIDS; Dementia in human immunodeficiency virus (HIV) disease; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Deoxypyrimidine Kinase; Deoxythymidine Kinase; Development; Development and Research; Dose-Limiting; Drug resistance; Drugs; E-B Virus; EB virus; EBV; EC 2.7; EC 2.7.1.21; EC 2.7.7.7; Emerging Communicable Diseases; Epilepsy; Epileptic Seizures; Epileptics; Epstein Barr Virus; Epstein-Barr Virus; Evaluation; Exanthema Subitum; Exhibits; Family; Foscarnet; Future; Ganciclovir; Gancyclovir; Generations; Genital; Genital system; Glandular Fever; Glaxo Wellcome Brand of Aciclovir; Glaxo Wellcome Brand of Aciclovir Sodium Salt; Goals; Grafting Procedure; HBLV; HCMV; HHV-1; HHV-2; HHV-3; HHV-4; HHV-6; HHV-6A; HHV-6B; HHV-7; HHV-8; HHV6; HHV8; HIV Dementia; HIV associated dementia; HIV-1 associated dementia; HIV-1 dementia; HIV-Associated Cognitive Motor Complex; HIV-related dementia; HPMPC; HSV-1; HSV-2; HSV1; HSV2; Health; Herpes Simplex Virus 1; Herpes Simplex Virus 2; Herpes Simplex Virus Type 1; Herpes Simplex Virus Type 2; Herpes Zoster; Herpes zoster Virus; Herpes zoster disease; Herpesviridae; Herpesvirus 1 (alpha), Human; Herpesvirus 1, Human; Herpesvirus 2 (alpha), Human; Herpesvirus 2, Human; Herpesvirus 3 (alpha), Human; Herpesvirus 4 (gamma), Human; Herpesvirus 4, Human; Herpesvirus 6, Human; Herpesvirus 7, Human; Herpesvirus progenitalis; Herpesvirus varicellae; Herpesviruses; Human; Human (alpha) herpes virus 2; Human B-Lymphotropic Virus; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 6; Human Herpesvirus 6A; Human Herpesvirus 6B; Human Herpesvirus 7; Human herpes simplex virus type 1; Human herpes simplex virus type 2; Human herpesvirus 1; Human herpesvirus 3; Human herpesvirus type 1; Human, Adult; Human, General; Immunocompromised; Immunocompromised Host; Immunocompromised Patient; Immunosuppressed Host; Individual; Infection; Infectious Diseases, Emerging; Infectious Mononucleosis; Infectious Mononucleosis Virus; Isomerism; KSHV; Kaposi - Kaposi's Sarcoma; Kaposi Sarcoma; Kaposi Sarcoma-Associated Herpes Virus; Kaposi Sarcoma-Associated Herpesvirus; Kaposi?s Sarcoma; Kinases; Lead; Lesion; Life; Lytotoxicity; Man (Taxonomy); Man, Modern; Medication; Medicinal Chemistry; Modification; Multiple Hemorrhagic Sarcoma; Nasopharyngeal Carcinoma; Nasopharynx Carcinoma; New Agents; Nordeoxyguanosine; Ocular Herpes zoster Virus; Oncogenic; Oral; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Parke Davis Brand of Aciclovir; Pb element; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Preparations; Phase; Phosphinecarboxylic acid, dihydroxy-, oxide; Phosphonoformic Acid; Phosphotransferases; Polymerase Gene; Population; Poviral; Purine Nucleosides; R & D; R&D; Reticuloendothelial System, Bone Marrow; Roseola Infantum; SBIR; SBIRS (R43/44); Salivary Gland Viruses; Seizure Disorder; Series; Shingles; Sixth Disease; Small Business Innovation Research; Small Business Innovation Research Grant; Solid; Structure-Activity Relationship; Thymidine Kinase; Toxic effect; Toxicities; Toxicology; Transphosphorylases; Transplantation Surgery; VZ Virus; Variant; Variation; Varicella; Varicella-Zoster Virus; Viral; Virorax; Virus; Virus-HHV6; Virus-HHV8; Viruses, General; Warner Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir Sodium Salt; Zona; Zoster; Zovirax; Zovirax for Injection; adult human (21+); analog; chemical structure function; clinical epidemiology; cytomegalovirus group; cytotoxicity; drug resistant; drug/agent; epilepsia; epileptiform; epileptogenic; gammaherpesvirus; heavy metal Pb; heavy metal lead; herpes simplex i; herpes simplex ii; herpes virus; herpes virus 1, human; herpes zona; human alphaherpesvirus 1; human alphaherpesvirus 2; human alphaherpesvirus 3; human cytomegalovirus; human herpesvirus 4 group; human herpesvirus 8; immunosuppressed patient; improved; in vivo; inhibitor; inhibitor/antagonist; isomer; member; mononucleosis; novel; nucleoside analog; organ allograft; organ graft; organ xenograft; pathogen; pediatric; public health relevance; research and development; resistance to Drug; resistant to Drug; structure function relationship; urogenital system (genital part)",Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents, PROJECT NARRATIVE The hypothesis of this proposal is that extensive chemical modification of the MP compounds will identify new molecules with even greater potency and efficacy specifically against HHV-6 and HHV-8. Proven medicinal chemistry structure activity relationship (SAR) approaches will be used to improve the potency of the MP compound series against HHV-6 and HHV-8. The overall goal of this proposal is to develop novel therapies for the emerging infectious diseases HHV-6 and HHV-8.,82799,ZRG1,Special Emphasis Panel,,2,313028,
7754064,R43,GM,5,,01/01/2010,12/31/2010,PAR-07-160,5R43GM083346-02,,NIGMS:149998;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN DIEGO,UNITED STATES,,50,170727486,US,CA,92128,"BIOFORMATIX, INC.","WROBLEWSKI, DARIUSZ ;",8437843;,5R43GM083346,01/01/2009,12/31/2010,"Address; Analysis, Data; Benchmarking; Best Practice Analysis; Biological; Biological Neural Networks; Body Tissues; Cells; Clinical; Cognitive Discrimination; Common Rat Strains; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Data Analyses; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Detection; Development; Diagnostic; Differential Gene Expression; Discrimination; Discrimination (Psychology); Disease; Disorder; Effectiveness; Elements; Expression Profiling; Expression Signature; Feasibility Studies; Forecast of outcome; Foundations; Gaussian Distribution; Gene Action Regulation; Gene Expression; Gene Expression Microarray Analysis; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genomics; Gray; Gray unit of radiation dose; Institutes; Mammals, Mice; Mammals, Rats; Methods; Mice; Microarray Analysis; Microarray-Based Analysis; Modeling; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Noise; Normal Distribution; Normal Statistical Distribution; Normal Tissue; Normal tissue morphology; Organ; Organism; PCR; Pattern; Performance; Pharmacogenomics; Phase; Polymerase Chain Reaction; Principal Component Analyses; Principal Component Analysis; Prognosis; Rat; Rattus; Research; Sampling; Statistical Methods; Stress; Structure; Students; Technology; Testing; Tissue Differentiation; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Toxicogenomics; Transcript; Validation; base; biomarker; clinical data repository; clinical data warehouse; computational framework; computer framework; cost; data repository; disease/disorder; experiment; experimental research; experimental study; improved; living system; microarray technology; molecuar profile; molecular signature; neural network; new approaches; novel; novel approaches; novel strategies; novel strategy; outcome forecast; public health relevance; relational database; research study; response; tool",Computational framework for analysis of microarray gene expression data,,83346,ZRG1,Special Emphasis Panel,,2,149998,
7760133,R43,MH,5,,02/01/2010,01/31/2011,PA-06-015,5R43MH081554-02,,NIMH:175588;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,PITTSBURGH,UNITED STATES,,14,602425949,US,PA,152382940,"PHFR, INC.","MCCLURE, RICHARD JAMES;",8841422;,5R43MH081554,02/01/2009,01/31/2011,"1H- Nuclear Magnetic Resonance Spectroscopic Imaging; Alcoholism; Analysis, Data; Basal Ganglia; Basal Nuclei; Bayesian Method; Bilateral; Brain; Brain imaging; Brain region; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chronic; Chronic Disease; Chronic Illness; Chronic Schizophrenia; Clinical; Code; Coding System; Cognition; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Color; Computer Programs; Computer software; Creatine; Creatine Phosphate; Data; Data Analyses; Data Set; Dataset; Disease; Disorder; Disturbance in cognition; Encephalon; Encephalons; Evaluation; Female; Funding; Future; Gangliosides; Glutamates; Glycine, N-(aminoiminomethyl)-N-methyl-; Glycine, N-(imino(phosphonoamino)methyl)-N-methyl-; Goals; Government; High Prevalence; History; Impaired cognition; Impairment; Individual; Inferior; Intermediary Metabolism; L-Glutamate; Lead; Left; Life; METBL; MR Spectroscopy; MRS; MRSI; Magnetic Resonance Spectroscopy; Measures; Membrane; Metabolic; Metabolic Processes; Metabolism; Method, Bayesian; Methods; Molecular; Monitor; Morbidity; Morbidity - disease rate; N-acetyl aspartate; N-acetyl-1-Asp-Glu; N-acetyl-L-aspartate; N-acetyl-aspartyl-glutamate; N-acetylaspartate; N-acetylaspartylglutamate; NIAAA; NIH; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Institutes of Health (U.S.); Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurobiology; Neurocognition; Neurocyte; Neuron Degeneration; Neurons; Neuropsychologic Tests; Neuropsychological Tests; Nicotine; Non-smoker; Occipital lobe; Outcome; Parietal Lobe; Parietal Lobe of the Brain; Patients; Pb element; Persons; Phase; Phosphates; Phosphatides; Phosphocreatine; Phospholipid Metabolism; Phospholipids; Phosphorylcreatine; Pilot Projects; Population Control; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopic Imaging; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Recording of previous events; Risk; STTR; SUBGP; Schizophrenia; Schizophrenic Disorders; Sensitivity and Specificity; Sialoglycosphingolipids; Small Business Technology Transfer Research; Smoke; Smoker; Smoking; Software; Specificity; Statistical Methods; Structure; Subcellular Process; Subgroup; Symptoms; Synapses; Synaptic; TXT; Temporal Lobe; Testing; Text; Therapeutic; Time; Training; United States National Institutes of Health; Work; base; biomarker; brain visualization; chronic disease/disorder; chronic disorder; cognitive change; cognitive dysfunction; cognitive loss; cognitively impaired; computer program/software; dementia praecox; design; designing; disease/disorder; heavy metal Pb; heavy metal lead; in vivo; inorganic phosphate; insight; magnetic resonance spectroscopic imaging; male; membrane structure; mid life; mid-life; middle age; middle aged; midlife; neural; neural degeneration; neurobiological; neurodegeneration; neuron cell death; neuron loss; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuropsychiatric; neuropsychiatry; neuropsychological; nonsmoker; novel; occipital cortex; parietal cortex; phosphodiester; phosphomonoester; pilot study; prevent; preventing; public health relevance; relating to nervous system; repair; repaired; response; schizophrenic; sugar; temporal cortex; temporal lobe/cortex",Biomarker for Cognitive Impairment in Chronic Schizophrenia, 7. Project Narrative  A brain molecular biomarker such as proposed in this application could be used to guide further understanding of the molecular underpinnings of cognitive impairment in chronic schizophrenia. This will enhance future therapeutic and preventative approaches designed to repair or prevent neural membrane damage observed in schizophrenia. The molecular biomarker will be used to develop a software package that will analyze individual 31P and 1H magnetic resonance spectroscopic imaging data and produce a color-coded brain image showing how that subject compares to a control population.,81554,ZRG1,Special Emphasis Panel,,2,175588,
7777763,R43,MH,5,,01/01/2010,12/31/2010,PA-07-424,5R43MH085370-02,,NIMH:243564;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NEW YORK,UNITED STATES,,08,927851295,US,NY,100103509,SOCIAL SCIENCES INNOVATIONS CORPORATION,"ECKHARDT, ELIZABETH A;",9428334;,5R43MH085370,03/01/2009,12/31/2010,"Accident and Emergency department; Active Follow-up; Advisory Committees; American Sign Language; CD-ROM; CD-ROM (Compact Disc-Read Only Memory); CDROM; Caring; Clinical; Communication; Communities; Compact Disk Read-Only Memory; Confidentiality; DSM-IV; DSM4; Deaf; Depression; Depression screen; Diagnosis; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Disadvantaged; Disease; Disorder; Early identification; Emergencies; Emergency Department; Emergency Situation; Emergency room; Emotional Depression; English Language; Ensure; Face; Fear; Focus Groups; Fright; General Population; General Public; Hard of Hearing Persons; Health; Health Care Providers; Health Personnel; Health Services; Healthcare Providers; Healthcare Systems; Healthcare worker; Hearing; Hearing Impaired Persons; Individual; Interview; Investigators; Language; Linguistic; Linguistics; Medical; Mental Depression; Mental Health; Mental Health Services; Mental Hygiene; Mental Hygiene Services; Mental disorders; Mental health disorders; Methodology, Research; Methods; Nature; Patients; Persons; Persons With Hearing Impairments; Phase; Physicians; Pilot Projects; Population; Preventive; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Privacy; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Reading; Research; Research Methodology; Research Methods; Research Personnel; Researchers; Role; SBIR; SBIRS (R43/44); Screening procedure; Self-Administered; Sensitivity and Specificity; Services; Sign Language; Small Business Innovation Research; Small Business Innovation Research Grant; Stigmata; Symptoms of depression; Systems, Health Care; Task Forces; Testing; Time; Underserved Population; Unspecified Mental Disorder; Visit; Work; Writing; base; computerized; depression screening; depressive; depressive symptoms; disability; disease/disorder; effective therapy; experience; facial; follow-up; functional status; health care personnel; health care service; health care worker; health provider; healthcare personnel; hearing perception; instrument; literacy; medical personnel; meetings; mental illness; pilot study; privacy of information; prototype; psychological disorder; public health priorities; public health relevance; screening; screenings; skills; social role; social stigma; sound perception; stigma; treatment provider; under served population; underserved people",A Culturally and Linguistically Specific Deaf Depression Screener," Public Health Relevance Statement Depression is the most prevalent form of mental illness in the US, causing disability and loss of work time comparable to major physical illness. The identification of depression in underserved populations, such as the deaf population, at the time of visits to primary care is a public health priority. The proposed project will develop a culturally and linguistically specific depression screener in American Sign Language, for use in primary care and other health and service settings.",85370,ZRG1,Special Emphasis Panel,,2,243564,
7776993,R44,AI,5,,03/01/2010,02/28/2011,PA-06-134,5R44AI064045-04,,NIAID:470619;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,Newport,UNITED STATES,,04,137313813,US,NC,28570,"ALDERON BIOSCIENCES, INC.","HENKENS, ROBERT W;",6276032;,5R44AI064045,11/01/2004,02/28/2012,"0-11 years old; AIDS; AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Anti-HIV Positivity; Assay; Bioassay; Biologic Assays; Biological Assay; Care, Health; Caring; Child; Child Youth; Children (0-21); Clinical; Clinical Trials, Phase III; Complex; Consult; DNA Molecular Biology; Deoxynucleotide-triphosphate[{..}]DNA deoxynucleotidyltransferase (RNA-directed); Detection; Development; Development Plans; Development and Research; Diagnosis; Diagnostic; Diagnostic tests; Diamond; Disasters; Disease; Disorder; Drugs; EC 2.7.7.49; Engineering; Engineerings; Environment; Enzymes; FDA approved; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Goals; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Seroconversion; HIV Seropositivity; HIV-1; HIV-2; HIV-I; HIV-II; HIV1; HIV2; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; HTLV-IV; Healthcare; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type IV; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Human, Child; Immunodeficiency Virus Type 1, Human; Immunodeficiency Virus Type 2, Human; Immunologic Deficiency Syndrome, Acquired; Individual; Instrumentation, Other; LAV-2; LAV-HTLV-III; Laboratories; Laboratory Research; Lead; Letters; Life; Lymphadenopathy-Associated Virus; MeSH Descriptors Class 4; Measurement; Measures; Medication; Methods; Molecular Biology; Monitor; NIAID; National Institute of Allergy and Infectious Disease; Optics; Patients; Pb element; Performance; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase; Phase 3 Clinical Trials; Phase III Clinical Trials; Plans, Development; Play; Poverty; Predisposition; Primary Care; Primary Health Care; Primary Healthcare; Procedures; Product Approvals; Protocol; Protocols documentation; Quality of Health Care; Quality of Healthcare; R & D; R&D; R01 Mechanism; R01 Program; RNA Transcriptase; RNA, Viral; RNA-Dependent DNA Polymerase; RNA-Directed DNA Polymerase; RPG; Reagent; Relative; Relative (related person); Research; Research Grants; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research, Laboratory; Resources; Reverse Transcriptase; Revertase; Role; SBIR; SBIRS (R43/44); Sales; Sampling; Science of Virology; Series; Small Business Innovation Research; Small Business Innovation Research Grant; Staging; Susceptibility; System; System, LOINC Axis 4; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; TimeLine; Validation; Viral; Viral Activity; Viral Burden; Viral Function; Viral Load; Viral Load result; Viral Physiology; Viral load measurement; Virology; Virus-HIV; WHO; Work; World Health Organization; antibody positive AIDS test; antigen positive AIDS test; base; children; commercialization; cost; disease/disorder; drug/agent; geographic site; health care quality; heavy metal Pb; heavy metal lead; human T cell leukemia virus III; human T lymphotropic virus III; improved; innovate; innovation; innovative; instrument; instrumentation; intervention therapy; new diagnostics; next generation diagnostics; novel diagnostics; phase 3 study; phase 3 trial; phase III trial; point of care; prevent; preventing; product development; protocol, phase III; public health relevance; research and development; research facility; sensor; seropositive (AIDS test); social role; study, phase III; success; tool; viral RNA; virology; virus RNA; virus load; youngster",Electrochemical RT Activity Assay for Measuring HIV Load," Narrative An estimated 33.2 million people are now living with HIV disease worldwide and in 2007 it claimed the lives 2.1 million people, including 330,000 children (World Health Organization). To address the urgent need for better treatment and diagnostic testing of HIV infected people, Alderon Biosciences, Inc. proposes to further develop a low-cost and easy-to-use electrochemical testing system (eSystem) for determinations of HIV viral load in clinical samples. Alderon's approach will make it possible to perform viral load testing in primary care or point-of-care (POC) environments and aid in monitoring and treating HIV positive patients in resource-limited environments.",64045,ZRG1,Special Emphasis Panel,,4,470619,
7759597,R44,AI,5,,02/01/2010,01/31/2011,PA-06-134,5R44AI071733-04,,NIAID:1149641;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SEATTLE,UNITED STATES,,07,154453018,US,WA,98119,ETUBICS CORPORATION,"JONES, FRANK R.;",9184083;,5R44AI071733,08/01/2006,01/31/2012,"AIDS; AIDS Virus; ATGN; Abscission; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adenoviral Vector; Adenoviridae; Adenoviridae Infections; Adenovirus Infections; Adenovirus Vector; Adenoviruses; Animals; Antigens; Cell Line; Cell Lines, Strains; CellLine; Cells; Characteristics; Clinical Trials; Clinical Trials, Unspecified; Communicable Diseases; DNA Polymerases; DNA Replication; DNA Synthesis; DNA biosynthesis; DNA, Viral; DNA-Dependent DNA Polymerases; DNA-Directed DNA Polymerase; Deoxynucleoside-triphosphate[{..}]DNA deoxynucleotidyltransferase (DNA-directed); Development; EC 2.7.7.7; Excision; Extirpation; FLR; Failure (biologic function); Frequencies (time pattern); Frequency; Gagging; Gene Delivery; Gene Products, gag; Generations; Genetic; Goals; HIV; HIV vaccine; HIV-1; HIV-1 vaccine; HIV-I; HIV/AIDS Vaccines; HIV1; HIV1 vaccine; HTLV-III; Head; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, General; IFN; Immune; Immune response; Immune system; Immunity; Immunization; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Immunologic Stimulation; Immunologic, Immunochemical; Immunological Stimulation; Immunologics; Immunostimulation; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Interferons; Intramuscular; Intravenous; LAV-HTLV-III; Lead; Light; Lymphadenopathy-Associated Virus; Lymphocyte; Lymphocytic; Lytotoxicity; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Murine; Mus; Pb element; Phase; Photoradiation; Polymerase; Production; Proteins; Reflex, Pharyngeal; Regimen; Removal; Retroviral Antigen gag Protein; Route; SBIR; SBIRS (R43/44); SCHED; SIV; Saccharose; Sampling; Schedule; Sensitization, Immunologic; Sensitization, Immunological; Simian Immunodeficiency Viruses; Small Business Innovation Research; Small Business Innovation Research Grant; Sucrose; Surgical Removal; System; System, LOINC Axis 4; Transgenes; Triad; Triad Acrylic Resin; Triad resin; Vaccinated; Vaccination; Vaccines; Viral Gene Products; Viral Gene Proteins; Viral Proteins; Viral gag Proteins; Virus; Virus-HIV; Viruses, General; adeno vector; adenovector; alpha-D-Glucopyranoside, beta-D-fructofuranosyl; base; body system, allergic/immunologic; clinical investigation; cultured cell line; cytotoxicity; failure; gag Antigens; gag Gene Products; gag Polyproteins; gag Protein; gene product; group specific antigen; heavy metal Pb; heavy metal lead; host response; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; immunogen; immunogenicity; immunoresponse; in vivo; intraperitoneal; lymph cell; new vaccines; next generation vaccines; novel vaccines; organ system, allergic/immunologic; phase 2 study; plasmid vaccine; pre-clinical; preclinical; preclinical study; public health relevance; resection; response; safety testing; transgene expression; vector; vector vaccine; vector-based vaccine; vector-induced; viral DNA; virus DNA; virus protein","Development of an Ad5 [E1-, E2b-] HIV-1 vaccine for use in Ad5 Immunized Vaccinee"," Sec.7* Narrative  Withapproximatel1y5,000newHIV-1infectionsoccurringdailyandthefailureoftheMerck'STEP"" HIVvacoinetrial,theneedforaviableHIV-1vaccineisurgent.Duringthisstudy,wewillfudherdevelopour advancedadenoviravl ectordeliverysystemforHIVvaccines.Thesystemis neededto breakthroughthe barrierpresentedbyvaccineeswhohavehadprioradenovirusinfectionswhichincludesmanyhumans worldwide.",71733,VACC,HIV/AIDS Vaccines Study Section,,4,1149641,
7767720,R44,CA,5,,02/01/2010,01/31/2011,CA-07-010,5R44CA130026-03,,NCI:913767;,2010,NATIONAL CANCER INSTITUTE,,WOBURN,UNITED STATES,,07,147950828,US,MA,018011003,CAMBRIDGE RESEARCH AND INSTRUMENTATION,"HOYT, CLIFFORD C;",1887114;,5R44CA130026,09/28/2007,01/31/2012,"AKT; ATGN; Abscission; Active Follow-up; Address; Affect; Akt protein; Algorithms; Animals; Antibodies; Antigenic Determinants; Antigens; Antigens, Nuclear; Archives; Area; Assay; Attention; Automation; Avastin; BAY 43-9006 Tosylate Salt; BAY 43-9006 tosylate (BAY 54-9085); BAY 54-9085; BBC1; BCL2-Interacting Killer Gene; BIK; BIK gene; BIP1; BP4; BZS; Benign; Bik/Nbk Gene; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Biological Preservation; Biology; Biometrics; Biometry; Biometry and Biostatistics; Biopsy; Biostatistics; Blotting, Western; Body Tissues; British Columbia; CD34; CD34 gene; Calibration; Cancer of Breast; Cancers; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cell Surface Receptors; Cell/Tissue, Immunohistochemistry; Cells; Certification; Classification; Clinical; Clinical Laboratory Information Systems; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Cognitive Discrimination; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Computer Programs; Computer software; Computers; Correlative Study; Coupled; Crossmatching, Tissue; Data; Detection; Development; Diagnosis, Ultrasound; Diaphanoscopy; Discrimination; Discrimination (Psychology); Disease; Disorder; Drug Industry; Drugs; EGFR; ERBB Protein; ERBB1; Echography; Echotomography; Electromagnetic, Microwave; Elements; Employment; Energy Transfer; Engineering; Engineerings; Ensure; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epitopes; Evaluation; Event; Excision; Extirpation; Fetal Liver Kinase-1; Fixation; Fixatives; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Fluorescence; Forecast of outcome; Formalin; Funding; Future; Genentech brand of trastuzumab; Generations; Goals; Guidelines; HER1; HPCA1; Harvest; Head and Neck, Thyroid; Herceptin; Histocompatibility Testing; Hoffman-La Roche brand of trastuzumab; Hour; Human; Human, General; IHC; Illumination; Image; Image Analyses; Image Analysis; Imagery; Imaging technology; Immunofluorescence; Immunofluorescence Immunologic; Immunohistochemistry; Immunohistochemistry Staining Method; Immunologic, Immunofluorescence; Individual; Industry; Industry, Pharmaceutic; Instrumentation, Other; Intracellular Communication and Signaling; KDR Tyrosine Kinase; Kidney; Kinase Insert Domain Receptor; Label; Laboratory Information Systems; Learning; Learning, Machine; Length; Life; Light; Lighting; Location; MAP-ERK Kinase; MAPK ERK Kinases; MEKs; MHAM; MMAC1; Machine Learning; Malignant; Malignant - descriptor; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Mammals, Mice; Man (Taxonomy); Man, Modern; Manuals; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Medical Imaging, Ultrasound; Medication; Medicine; Membrane; Metabolic; Methods; Methods and Techniques; Methods, Other; Mice; Microwaves; Modality; Modeling; Molecular; Monitor; Murine; Mus; NBK; Nuclear Antigens; Nuclear Protein; Nuclear Proteins; Nucleus; Operation; Operative Procedures; Operative Surgical Procedures; Optics; Outcome; PKB protein; PTEN; PTEN gene; PTEN1; Paraffin Embedding; Pathologist; Pathology; Pathway interactions; Patient Care; Patient Care Delivery; Patient Focused Care; Patients; Penetration; Pennsylvania; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phosphatase and Tensin Homolog; Phosphoproteins; Photoradiation; Pilot Projects; Play; Polymers; Predisposition; Preservation, Biologic; Preservation, Biological; Procedures; Process; Prognosis; Protein Kinase B; Proteins; Proto-Oncogene Proteins c-akt; Protocol; Protocols documentation; RAC-PK protein; ROC Analysis; Reaction; Reading; Reagent; Receptor Activation; Receptor, EGF; Receptor, TGF-alpha; Receptor, Urogastrone; Receptors, Cell Surface; Receptors, Epidermal Growth Factor-Urogastrone; Removal; Reporting; Research Design; Research Resources; Research Specimen; Resources; Risk; Roche brand of trastuzumab; Role; Sampling; Scanning; Science of Medicine; Science of Statistics; Segmentation, imaging; Shapes; Side; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Slide; Software; Sorafenib; Source; Specificity; Specimen; Staining method; Stainings; Stains; Statistics; Study Type; Surgical; Surgical Interventions; Surgical Procedure; Surgical Removal; Susceptibility; System; System, LOINC Axis 4; Systematics; Techniques; Technology; Testing; Thick; Thickness; Thyroid; Thyroid Gland; Time; Tissue Arrays; Tissue Chip; Tissue Crossmatchings; Tissue Fixation; Tissue Microarray; Tissue Sample; Tissue Typing; Tissues; Toxic effect; Toxicities; Training; Transforming Growth Factor alpha Receptor; Transillumination; Translating; Translatings; Tumor Tissue; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; Urinary System, Kidney; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptors; VEGFR; VEGFR-2; VEGFR2; VEGFs; VPF Receptor; Validation; Variant; Variation; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Permeability Factor Receptor; Vegf; Visualization; Weight; Western Blotting; Western Blottings; Western Immunoblotting; Work; abstracting; angiogenesis; base; biological signal transduction; c-akt protein; c-erbB-1; c-erbB-1 Protein; clinical investigation; clinical material; clinical practice; commercialization; computer program/software; design; designing; diagnostic ultrasound; disease/disorder; drug development; drug/agent; erbB-1; erbB-1 Proto-Oncogene Protein; erbBl; experiment; experimental research; experimental study; flexibility; follow-up; gene product; histocompatibility typing; image evaluation; image processing; imaging; imaging Segmentation; immunogen; improved; instrumentation; interest; kernel methods; language translation; lapatinib; malignancy; malignant breast neoplasm; melanoma; member; membrane structure; method development; microwave electromagnetic radiation; microwave radiation; molecular pathology; mouse model; nano particle; nanoparticle; neoplasm/cancer; new technology; novel; outcome forecast; pathway; pilot study; preservation; prospective; protein blotting; protein expression; protein folding; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; proto-oncogene protein c-erbB-1; rac protein kinase; related to A and C-protein; renal; research study; resection; response; sample fixation; social role; sonogram; sonography; sound measurement; statistical learning; statistics; statistics/biometry; study design; subcutaneous; support vector machine; surgery; tissue culture; tissue processing; tissue/cell culture; tool; treatment response; tumor; ultrasound; ultrasound imaging; ultrasound scanning; validation studies",Cellularly resolved molecular pathway assessment in biopsies via spectral imaging,,130026,ZCA1,Special Emphasis Panel,,3,913767,
7766240,R44,DA,5,,01/01/2010,12/31/2010,PA-07-280,5R44DA025366-03,,NIDA:419942;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,ENGLEWOOD,UNITED STATES,,09,019939545,US,NJ,076312807,"BIOSTATISTICAL PROGRAMMING ASSOC, INC.","BORENSTEIN, MICHAEL ;",8224156;,5R44DA025366,06/01/2008,12/31/2010,"20 year old; ANOVA; Accounting; Address; Advertising; Affect; Aged 65 and Over; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Am 80; Am80; Ambulances; American; Analysis of Variance; Analysis, Data; Apoplexy; Area; Au element; Benzoic acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-; Caring; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of smoking; Clinic; Clinical Trials Design; Clinics and Hospitals; Clinics or Hospitals; Cluster Analyses; Cluster Analysis; Communities; Complex; Computer Programs; Computer software; Data; Data Analyses; Data Banks; Data Bases; Data Collection; Databank, Electronic; Databanks; Database, Electronic; Databases; Dimensions; Drops; Drug usage; Drugs, Illicit; Editorial; Editorial (PT); Editorial [Publication Type]; Elderly; Elderly, over 65; Enrollment; Epidemic Acute Poliomyelitis; Equilibrium; EtOH drinking; Event; Fall prevention; Frequencies (time pattern); Frequency; Funding Agency; Funding Source; Gerontology; Goals; Gold; Graph; Grips; HOSP; Health; Heart; Home; Home environment; Hospitals; Illicit Drugs; Individual; Intervention; Intervention Strategies; Investigators; Job Environment; Job Location; Job Place; Job Setting; Job Site; Journals; Lead; Life; Literature; Magazine; Medical; Medicine; Methods and Techniques; Methods, Other; Minnesota; Modeling; Mortality; Mortality Vital Statistics; Negative Finding; Output; PROV; Palliative Care; Palliative Treatment; Patients; Pb element; Persons; Play; Policy Research; Polio; Poliomyelitis; Poliomyelitis, Acute; Preventive Medicine; Primary Care; Primary Health Care; Primary Healthcare; Procedures; Process; Programs (PT); Programs [Publication Type]; Provider; PubMed; Public Health; Publishing; Randomized; Recruitment Activity; Reporting; Research; Research Design; Research Personnel; Research Resources; Researchers; Resources; Risk; Role; Sample Size; Sampling; Schools; Science of Medicine; Series; Services; Side; Social Policies; Social Sciences; Software; Stroke; Structure; Students; Study Type; Sum; Survey Instrument; Surveys; Survival Analyses; Survival Analysis; Tail; Techniques; Testing; Therapy, Palliative; Time; Vaccines; Variance Analyses; Vascular Accident, Brain; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; advanced age; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; balance; balance function; biogerontology; brain attack; cease smoking; cerebral vascular accident; clinical data repository; clinical data warehouse; comfort care; computer program/software; cooking; cost; data repository; design; designing; develop software; developing computer software; drug use; editorial; elders; enroll; ethanol abuse; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; geriatric; grasp; hazardous alcohol use; heavy metal Pb; heavy metal lead; improved functioning; interventional strategy; late life; later life; motivational enhancement therapy; motivational interview; older adult; older person; preventative medicine; problem drinking; programs; public health medicine (field); public health relevance; randomisation; randomization; randomized trial; randomly assigned; recruit; relational database; senior citizen; simulation; smoking cessation; social role; software development; stroke; study design; substance abuse prevention; treatment effect; trend; twenty year old; wasting; work environment; work setting",Power Analysis for Cluster Randomized Trials," Project narrative Cluster randomized trials are trials in which intact units such as hospitals, clinics, or schools, are randomly assigned to a condition such as Treatment or Control. These kinds of trials play a prominent role in medicine, health, and social policy research, with as many as 1,000 such trials being planned each year. The goal of this project is to develop software to perform a power analysis for cluster randomized trials, and enable researchers to design these trials in a manner that yields maximum power for the smallest cost.",25366,ZRG1,Special Emphasis Panel,,3,419942,
7744642,R44,EY,5,,01/01/2010,12/31/2010,PA-08-050,5R44EY017228-03,,NEI:411321;,2010,NATIONAL EYE INSTITUTE,,Maple Grove,UNITED STATES,,03,140696332,US,MN,55369,KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT,"LICHTER, PATRICK ALLAN;",7669852;,5R44EY017228,05/01/2006,12/31/2010,"Access to Information; Aged 65 and Over; Algorithms; Awareness; Awarenesses; Behavioral; Biomedical Technology; Blindness; Canes; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Phone; Cell Signaling; Cellular Phone; Characteristics; Clip; Cognitive; Computer Programs; Computer software; Cues; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Destinations; Development; Devices; Disadvantaged; Distal; Dogs; Elderly; Elderly, over 65; Environment; Evaluation; Freedom; GIS; Geographic Information Systems; Goals; Government; Head; Hearing; Human; Human, General; IT Systems; Individual; Information Systems; Information Technology Systems; Instruction; Intracellular Communication and Signaling; Investigators; Left; Liberty; Life; Literature; Location; Mammals, Dogs; Man (Taxonomy); Man, Modern; Maps; Marketing; Measures; Modification; Movement; Navigation System; Obstruction; Olfaction; Olfactions; Operation; Operative Procedures; Operative Surgical Procedures; Partial Sight; Perception; Performance; Persons; Phase; Pilot Projects; Population; Position; Positioning Attribute; Process; Production; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Reading; Recommendation; Research; Research Personnel; Researchers; Route; SBIR; SBIRS (R43/44); Services; Sight; Signal Transduction; Signal Transduction Systems; Signaling; Small Business Innovation Research; Small Business Innovation Research Grant; Smell; Smell Perception; Social Support System; Societies; Software; Solutions; Specific qualifier value; Specified; Speech; Support System; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Technology; Telephone, Cellular; Testing; Time; Touch; Touch sensation; Travel; Update; Vision; Vision Disorders; Vision, Diminished; Vision, Low; Vision, Reduced; Vision, Subnormal; Visual Disorder; Visual impairment; Visually Impaired Persons; Voice; WHO; Walking Sticks; Work; World Health Organization; advanced age; age dependent; age related; attenuation; base; biological signal transduction; blind; blind individual; blind people; blind person; body movement; cane, includes canes of all materials, adjustable or fixed, with tip; canine; clinical data repository; clinical data warehouse; commercialization; computer program/software; cost; data repository; design; designing; domestic dog; elders; evaluation/testing; geographic information system; geriatric; hearing perception; improved; input device; late life; later life; meetings; navigation aid; navigation aide; new technology; older adult; older person; outreach to information; pilot study; programs; prototype; public health relevance; relational database; senior citizen; sound perception; spatial navigation; stem; surgery; visually impaired; visually impaired people; way finding; wayfinding",Indoor Personal NavigationSystem for the Blind Using Augmented GPS, Project Narrative The goal of this project is to develop a personal indoor navigation device using high-sensitive GPS augmented with dead-reckoning technology.,17228,ZRG1,Special Emphasis Panel,,3,411321,
7643132,R44,HL,5,,01/01/2010,12/31/2010,PA-07-280,5R44HL072547-03,,NHLBI:332704;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,AURORA,UNITED STATES,,07,780997065,US,CO,80045,"VALVEXCHANGE, INC.","VESELY, IVAN ;",7895723;,5R44HL072547,07/01/2008,12/31/2010,"Abate; Abscission; Address; Adhesions; Age; Age-Years; Animal Model; Animal Models and Related Studies; Animals; Anticoagulant Agents; Anticoagulant Drugs; Anticoagulants; Anticoagulation; Apex of the Heart; Apoplexy; Artificial Heart; Au element; Autopsy; Biocompatible Materials; Biomaterials; Bioprosthesis; Bioprosthesis device; Bioprosthetic; Bleeding; Body Tissues; Bypass; C element; Carbon; Cardiac; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cardiac Valves; Cardiac artery; Cardiac conduction system; Catheters; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Chromium; Chronic; Clinical; Clip; Co element; Cobalt; Control Groups; Coronary artery; Cr element; Devices; Docking; Excision; Extirpation; Fibrosis; Figs; Figs - dietary; Generations; Gold; Grant; Graphite; Hand; Healed; Heart; Heart Conduction System; Heart Valves; Heart artery; Heart, Artificial; Hemorrhage; Hour; Immune response; Implant; Incidence; Investigators; LTIC; Life; Life Style; Lifestyle; Manufacturer; Manufacturer Name; Marketing; Measurement; Measures; Mechanics; Medical Device; Metals; Mo element; Modeling; Molybdenum; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Natural graphite; Octadecanoates; Operation; Operative Procedures; Operative Surgical Procedures; Otomy; Ovis; Partner in relationship; Patients; Pericardial; Pericardial body location; Phase; Plant Roots; Position; Positioning Attribute; Pressure; Pressure- physical agent; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Prosthesis; Prosthetic device; Prosthetics; QOL; Quality of life; Removal; Reoperation; Repeat Surgery; Research Personnel; Research Specimen; Researchers; Risk; SBIR; SBIRS (R43/44); Sheep; Small Business Innovation Research; Small Business Innovation Research Grant; Specimen; Sports; Stearates; Steel; Stroke; Surface; Surgeon; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Surgical Removal; Surgical Revision; Surgical incisions; Surgical sutures; Sutures; System; System, LOINC Axis 4; Testing; Thromboembolism; Thrombosis; Time; Tissues; United States; Vascular Accident, Brain; Welding; Weldings; animal tissue; base; blood loss; blood thinner; brain attack; cardiac prosthesis; cerebral vascular accident; design; designing; elderly patient; experiment; experimental research; experimental study; healing; heart prosthesis; heart surgery; host response; immunoresponse; implantation; improved; incision; low temperature isotropic carbon; mate; mechanical heart; minimally invasive; model organism; necropsy; novel; older patient; phase 1 study; postmortem; pressure; prevent; preventing; programs; prototype; pyrolytic carbon; research study; resection; response; root; stroke; surgery; thrombopoiesis inhibitor; valve replacement",Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve,,72547,ZRG1,Special Emphasis Panel,,3,332704,
7752792,R44,MH,5,,01/21/2010,11/30/2010,PA-08-050,5R44MH080463-03,,NIMH:392579;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHAPEL HILL,UNITED STATES,,04,946517232,US,NC,27514,"TELESAGE, INC.","BRODEY, BENJAMIN B;",2093518;,5R44MH080463,05/26/2007,11/30/2010,"Accuracy of Diagnosis; Adoption; Au element; Clinical; Complex; Computer Assisted; Computer Programs; Computer software; DSM; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Disease; Disorder; Funding; Gold; HIPAA; Health Care Professional; Health Insurance Portability and Accountability Act; Health Professional; Health profession; Healthcare professional; Healthcare worker; Imagery; Individual; Internet; Interview; Interviewer; Investigators; Judgment; Kennedy Kassebaum Act; Knowledge; Learning; Length; Life; Logic; Medicine; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Methods; PL 104-191; PL104-191; Paper; Patients; Performance; Phase; Physiologic; Physiological; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Psychiatric Diagnosis; Psychiatric Disease; Psychiatric Disorder; Psychiatry; Psychological Health; Public Law 104-191; Publishing; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; SBIR; SBIRS (R43/44); Sampling; Science of Medicine; Side; Simulate; Small Business Innovation Research; Small Business Innovation Research Grant; Software; Software Validation; Software Verification; Structure; Symptoms; Technology; Testing; Training; Treatment outcome; United States Health Insurance Portability and Accountability Act; Unspecified Mental Disorder; Variant; Variation; Visualization; WWW; Work; base; clinical care; clinical data repository; clinical data warehouse; clinical practice; computer aided; computer program/software; computerized; cost; data repository; design; designing; diagnostic accuracy; disease/disorder; experience; flexibility; improved; instrument; mental illness; programs; prototype; psychological disorder; public health relevance; relational database; response; satisfaction; tool; usability; web; world wide web",Development and validation of software for Internet and PC SCID administration," NARRATIVE The Structured Clinical Interview for DSM-IV-TR (SCID), a lengthy and complex paper-and-pencil instrument, yields more accurate and reliable psychiatric diagnoses than do the type of unstructured patient interviews that predominate in clinical settings. The SCID, however, remains an unattractive option to most clinicians, in part because of the extensive training necessary to learn to administer it correctly, and because it is costly and cumbersome to reproduce and store. The objective of the proposed project, therefore, is to develop an Internet-based computer-assisted version of the SCID (Net SCID) that will facilitate more widespread adoption of this gold-standard diagnostic instrument by making the SCID easier and less expensive to use.",80463,ZRG1,Special Emphasis Panel,,3,392579,
7791401,R44,RR,5,,02/01/2010,01/31/2011,PA-08-050,5R44RR019780-03,,NCRR:394249;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,SAN MATEO,UNITED STATES,,12,608176715,US,CA,94404,"STOTTLER HENKE ASSOCIATES, INC.","EARL, CHARLES C;",7797768;,5R44RR019780,05/15/2004,01/31/2011,"Analysis, Data; Animals; Award; Behavior; Behavior Control; Behavioral; Behavioral Manipulation; Belief; Candy; Caring; Choices and Control; Collaborations; Companions; Competence; Computer Programs; Computer software; Computers; Confection; Consumption; Control Groups; Controlled Study; Curriculum; Data Analyses; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diagnosis; Diet good; Eating; Educational Curriculum; Environment; Evaluation; Feedback; Focus Groups; Food; Food Intake; Fostering; Frequencies (time pattern); Frequency; Grant; Group Interviews; Health; Health Care Costs; Health Costs; Health Sciences; Healthcare Costs; Healthy diet; Hydrogen Oxide; Intake; Intention; Interview; Interviews, Group; Learning; Life; Link; MODY; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Methods; Motivation; NCRR; NIDDM; NIH; National Center for Research Resources; National Institutes of Health; National Institutes of Health (U.S.); New York City; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Nutrition; Nutritional Science; Outcome; Participant; Phase; Physical activity; Play; Pre-Post Tests; Prevention; Process; Programs (PT); Programs [Publication Type]; Questionnaires; Randomized; Reporting; SBIR; SBIRS (R43/44); Schools; Science; Science of nutrition; Self Determination; Self Efficacy; Series; Simulate; Small Business Innovation Research; Small Business Innovation Research Grant; Societies; Software; Students; Survey Instrument; Surveys; T2D; T2DM; Testing; Tests, Pre-Post; Type 2 diabetes; Type II diabetes; United States National Institutes of Health; Universities; Visit; Water; Work; Youth; Youth 10-21; adult onset diabetes; aged; base; behavioral control; college; computer program/software; convenience food; drinking; fast food; flexibility; fruits and vegetables; improved; instrument; ketosis resistant diabetes; maturity onset diabetes; middle school; nutrition; obesity in children; population health; post intervention; programs; public health relevance; randomisation; randomization; randomly assigned; science education; screen time; skills; sweetened beverage; teacher; television watching; tv watching; usability; virtual",LiFESim: Software for Health Science Education, The principal benefit that we hope to achieve in LifeSim is to influence changes in eating and physical activity behaviors of the students using LifeSim to aid in the prevention of childhood obesity. We are looking at influencing the following specific behaviors and their influences:1) eat more fruit and vegetables; 2) drink fewer sweetened beverages and more water; 3) eat less frequently at fast food establishments; 4) eat fewer prepackaged snacks; 5) increase moderate and vigorous physical activity; and 6) decrease recreational screen-time. Society will benefit from this by having healthier youth and potential reduction in healthcare costs.,19780,ZRG1,Special Emphasis Panel,,3,394249,
7767730,S06,GM,5,,02/01/2010,01/31/2011,PAR-04-001,5S06GM008107-35,,NIGMS:87607;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,KINGSVILLE,UNITED STATES,BIOLOGY,27,868154089,US,TX,78363,TEXAS A&M UNIVERSITY-KINGSVILLE,"MASSA, ENRIQUE ;",8740071;,5S06GM008107,03/01/1997,01/31/2011,,MBRS SCORE Program at Texas A&M University-Kingsville,,8107,MPRC,Minority Programs Review Committee,,35,87607,
8019539,S06,GM,5,,02/01/2010,01/31/2011,,5S06GM008107-35,0001,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,KINGSVILLE,UNITED STATES,,27,868154089,US,TX,78363,TEXAS A&M UNIVERSITY-KINGSVILLE,"MASSA, ENRIQUE ;",8740071;,5S06GM008107,,,"Advisory Committees; Arts; Data; E-Mail; Electronic Mail; Email; Faculty; Grant; Human Resources; Individual; Infrastructure; Manpower; Organization Charts; Paper; Policies; Process; Programs (PT); Programs [Publication Type]; Progress Reports; R01 Mechanism; R01 Program; RPG; Reporting; Reports, Progress; Research; Research Grants; Research Infrastructure; Research Project Grants; Research Projects; Research Projects, R-Series; Scheme; Science; Supervision; System; System, LOINC Axis 4; Task Forces; Texas; Universities; Work; college; design; designing; organizational structure; personnel; programs",ADMINISTRATIVE CORE,,8107,MPRC,Minority Programs Review Committee,,35,,10440
8019540,S06,GM,5,,02/01/2010,01/31/2011,,5S06GM008107-35,0002,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,KINGSVILLE,UNITED STATES,,27,868154089,US,TX,78363,TEXAS A&M UNIVERSITY-KINGSVILLE,"LAURENZ, JAMIE C;",6163406;,5S06GM008107,,,"ADRGND; Acute-Phase Reaction; Acute-Phase State; Address; Adrenal Glands; Adrenals; Adrenergic Agonists; Adrenergic Antagonists; Adrenergic Blockaders; Adrenergic Blockers; Adrenergic Receptor; Adrenergic Receptor Agonist; Adrenergic Receptor Blockaders; Adrenergic-Blocking Agents; Adrenoceptors; Adrenolytic Agents; Adrenolytic Drugs; Adrenolytics; Adrenomimetics; Adverse effects; Affect; Agonist; Animal Model; Animal Models and Related Studies; Anti-Adrenergics; Antiadrenergic Agents; Antiadrenergics; Behavior Conditioning Therapy; Behavior Disorders; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Cancers; Cardiology; Cardiovascular Disease (Specialty); Chronic Disease; Chronic Illness; Clinical; Clinical, Transplantation, Organ; Collaborations; Common Rat Strains; Communicable Diseases; Conditioning Therapy; Development; Diabetic Diet; Diathesis; Disease; Disease susceptibility; Disorder; Employee Strikes; Endocrine; Family suidae; Future; Genetic; Gestation; Glucocorticoids; Goals; Grafting Procedure; HPA; Health; Hematopoiesis; Hematopoietic Cellular Control Mechanisms; History; Human; Human, General; INFLM; Immune; Immune Function, Cellular; Immune System Dysfunction; Immune System and Related Disorders; Immune system; Immunity; Immunocompetence; Immunodeficiency and Immunosuppression Disorders; Immunologic Competence; Immunological Competence; Immunological Dysfunction; Immunological System Dysfunction; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Inflammation; Inflammatory; Intervention; Intervention Strategies; Investigation; Knowledge; LPS; Lead; Life; Life Stress; Life Style Modification; Lipopolysaccharides; Malignant Neoplasms; Malignant Tumor; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Mediating; Mental Health; Mental Hygiene; Mice; Mission; Modeling; Mothers; Murine; Mus; NICHD; NIH; National Institute of Child Health and Human Development; National Institutes of Health; National Institutes of Health (U.S.); Neuroendocrine; Neuroendocrine System; Neuroimmune Mechanisms; Neuroimmune Processes; Neuroimmunomodulation; Neurosecretory Systems; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Outcome; Pb element; Personal Satisfaction; Physiologic; Physiological; Pigs; Predisposition; Pregnancy; Preventive Intervention; Process; Programs (PT); Programs [Publication Type]; Psychological Health; Rat; Rattus; Receptor Antagonists, Adrenergic; Receptor Protein; Receptors, Epinephrine; Recording of previous events; Research; Response, Acute-Phase; SNS; Science; Stress; Strikes; Strikes, Employee; Suidae; Susceptibility; Swine; Sympathetic Nervous System; System; System, LOINC Axis 4; Testing; Texas; Therapeutic Glucocorticoid; Transplantation Surgery; Treatment Side Effects; United States National Institutes of Health; Universities; Work; adenoreceptor; base; behavior intervention; behavioral disorder; behavioral intervention; biological adaptation to stress; body system, allergic/immunologic; chronic autoimmune disease; chronic disease/disorder; chronic disorder; conference; diabetes nutrition; disease/disorder; disease/disorder proneness/risk; fetal stress; genetic manipulation; heavy metal Pb; heavy metal lead; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; immune function; improved; in vivo; innovate; innovation; innovative; insight; intervention design; interventional strategy; liability to disease; malignancy; maternal stress; model organism; neoplasm/cancer; novel; organ allograft; organ graft; organ system, allergic/immunologic; organ xenograft; pathogen; porcine; postnatal; prenatal stress; preventional intervention strategy; programs; reaction; crisis; receptor; side effect; stress response; stress; reaction; stressed mothers; stressor; suid; suprarenal gland; symposium; therapy adverse effect; therapy design; treatment adverse effect; treatment design; well-being",Maternal Programming and Immune Function,,8107,MPRC,Minority Programs Review Committee,,35,,40381
8019541,S06,GM,5,,02/01/2010,01/31/2011,,5S06GM008107-35,0003,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,KINGSVILLE,UNITED STATES,,27,868154089,US,TX,78363,TEXAS A&M UNIVERSITY-KINGSVILLE,"GARCIA, MICHELLE R;",7867864;,5S06GM008107,,,"ANG1; ANG1 Gene; ANGPT1; ANGPT1 gene; AP-1; AP-1 Enhancer-Binding Protein; AP1; AP1 protein; Abortion, Habitual; Abortion, Recurrent; Accounting; Activator Protein-1; Adenohypophysis; Adipocytes; Adipose Cell; Angiogenic Factor; Angiopoietin 1 Gene; Angiopoietin-1; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Basement membrane; Basic Fibroblast Growth Factor Gene; Biochemical; Biomedical Research; Blood Vessels; Blood capillaries; Body Tissues; Body of uterus; Brain; Cannot achieve a pregnancy; Capillaries; Capillary; Capillary, Unspecified; Caprine Species; Cell Communication and Signaling; Cell Signaling; Chemotherapy-Hormones/Steroids; Corpus; Corpus Luteum; Corpus Luteum Hormone; Corpus Uteri; DNA; DNA Synthesis Factor; Data; Defect; Delta4-pregnene-3,20-dione; Deoxyribonucleic Acid; Development; Difficulty conceiving; Discontinuous Capillary; Dissociation; ECGF; Elements; Encephalon; Encephalons; Endocrine Gland Secretion; Endothelial Cell Growth Factor; Enhancer-Binding Protein AP1; Environment; Estrous Cycle; Experimental Models; Experimental Models, Other; Exposure to; FGF; FGF-2; FGF2; FGF2 gene; FGFB; Factor, Angiogenesis; Family suidae; Farm Animal; Fat Cells; Female; Fibroblast Growth Factor; Fibroblast Growth Factor 2; Fibroblast Growth Factor 2 Gene; Fibroblast Growth Factor, Basic; Fibroblast Growth Regulatory Factor; Gene Expression; Gene Proteins; Gene Transcription; Genetic Transcription; Genital System, Female, Ovary; Goat; Graafian Follicles; HBGF; HBGF-2; Habitual Abortion; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Histologic; Histologically; Hormones; HuB219; Human; Human, General; Infertility; Interna, Theca; Interstitial Cell Stimulating Hormone; Interstitial Cell-Stimulating Hormone; Intracellular Communication and Signaling; KIAA0003; LEP-R; LEPR; LEPR Protein; LTH; Lactogenic Hormone, Pituitary; Leptin; Leuteinizing Hormone; Lipocytes; Livestock; Livestocks; Luteal Phase; Luteinizing Hormone; Lutropin; Mammals, Goats; Mammals, Primates; Mammals, Rodents; Mammotropic Hormone, Pituitary; Mammotropin; Man (Taxonomy); Man, Modern; Mature Follicle; Mature Lipocyte; Mature fat cell; Mediating; Menstrual Cycle, Luteal Phase; Menstrual Cycle, Secretory Phase; Menstrual Secretory Phase; Messenger RNA; Metabolic; Miscarriage, Recurrent; Modeling; Models, Experimental; Nervous System, Brain; OB Receptor; OB-R; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein; Orthopedic; Orthopedic Surgical Profession; Orthopedics; Ovarian; Ovarian Tissue; Ovary; Ovulation; PRL; PRL (Prolactin); Pars Anterior Pituitary Gland; Photoperiod; Physiologic; Physiological; Physiology; Pigs; Pituitary Gland, Anterior; Pituitary Lutenizing Hormone; Play; Postovulatory Phase; Pregn-4-ene-3,20-dione; Pregnancy Maintenance; Pregnenedione; Primates; Process; Production; Progesterone; Programs (PT); Programs [Publication Type]; Prolactin; Property; Property, LOINC Axis 2; Prostate Epithelial Cell Growth Factor; Prostatropin; Protein Gene Products; Proteins; Psychology; RNA Expression; RNA, Messenger; Recombinant Luteinizing Hormone; Regulation; Reporting; Research; Rodent; Rodent Model; Rodentia; Rodentias; Role; Satiation; Satiations; Signal Transduction; Signal Transduction Systems; Signaling; Sinusoid; Sinusoidal Capillary; Site; Source; South Texas; Staging; Structure; Structure of corpus luteum of ovary; Suidae; Swine; Texas; Theca folliculi structure; Therapeutic Hormone; Therapeutic LH; Therapeutic Progesterone; Therapeutic Steroid Hormone; Tissues; Transcription; Transcription Activation; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Universities; Up-Regulation; Up-Regulation (Physiology); Upregulation; Uterine Body; VEGFs; Vascular Endothelial Growth Factors; Vascularization; Vegf; Woman; angiogenesis; bFGF; biological signal transduction; capillary; chronic spontaneous abortion; corpus luteum; cost; experiment; experimental research; experimental study; gene product; in vivo; infertile; leptin receptor; leptin-binding protein; luteotropic hormone; luteotropin; mRNA; ob/ob mouse; porcine; programs; protein expression; reproductive; research study; satiety; social role; steroid hormone; suid; unable to bear children; vascular",The Role of Leptin in Luteal Angiogenesis (pilot),,8107,MPRC,Minority Programs Review Committee,,35,,18393
8019542,S06,GM,5,,02/01/2010,01/31/2011,,5S06GM008107-35,0004,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,KINGSVILLE,UNITED STATES,,27,868154089,US,TX,78363,TEXAS A&M UNIVERSITY-KINGSVILLE,"STANKO, RANDY L;",7867890;,5S06GM008107,,,"0-11 years old; 12-20 years old; 21+ years old; Acceleration; Adipose tissue; Adolescence; Adult; Affect; African American; Afro American; Afroamerican; Age; Age of Onset; Agonist; Alternative Therapies; Animal Model; Animal Models and Related Studies; Autoregulation; BMI percentile; BMI z-score; Black Populations; Black or African American; Body Tissues; Body mass index; Bone; Bone Growth; Bone and Bones; Bones and Bone Tissue; Bovine Species; CCP; Cattle; Cell Communication and Signaling; Cell Signaling; Characteristics; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical; Clinical Treatment; Complement Control Protein Module; Complex; D-His-6-Pro-8-NEt-LHRH; Data; Delayed Puberty; Development; Diet; Disease; Disorder; Economics; Editorial; Editorial (PT); Editorial [Publication Type]; Employee Strikes; Endocrine; Endocrinology; Estrogenic Agents; Estrogenic Compounds; Estrogens; Estrous Cycle; Event; Exhibits; FSH-Releasing Hormone; Family suidae; Fatty Tissue; Female; Fertility/Fertilization; Fertilization; Future; GHN; Generalized Growth; Genetic; Genotype; GnRH (gonadotropin releasing hormone); Goals; Gonadal Steroid Hormones; Gonadoliberin; Gonadorelinum; Gonadotropin Hormone Releasing Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Growth; Growth Hormone; Growth Hormone 1; Hispanic Populations; Hispanics; Hispanics or Latinos; Hoe- 471; Homeostasis; Human; Human, Adult; Human, Child; Human, General; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Intracellular Communication and Signaling; Investigation; Knowledge; LH-FSH Releasing Hormone; LH-Releasing Hormone; LHFSH Releasing Hormone; Latino Population; Lead; Link; Liver; Luliberin; Luteinizing Hormone-Releasing Factor; Luteinizing Hormone-Releasing Hormone; Luteinizing hormone-releasing factor (pig); Maintenance; Maintenances; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Measures; Menarche; Metabolic; Metabolism and Endocrinology; Modeling; Nervous System, Pituitary; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nutrition; Nutritional Science; Nutritional status; Obesity; Ovarian; Ovulation; Pathology; Patients; Pb element; Peripheral; Physiologic; Physiological; Physiological Homeostasis; Pigs; Pilot Projects; Pituitary; Pituitary Gland; Pituitary Growth Hormone; Population; Population Study; Postpartum; Postpartum Period; Precocious Puberty; Pregnancy Maintenance; Programs (PT); Programs [Publication Type]; Puberty; Puberty, Delayed; Puberty, Precocious; Pulsti; Pump; Quetelet index; R01 Mechanism; R01 Program; RPG; Race; Racial Group; Recombinant Gonadorelin; Regulation; Reporting; Reproduction; Reproductive Endocrinology; Reproductive system; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Review Literature; SCR Repeat; STH; Science; Science of nutrition; Sex Characteristics; Sex Differences; Sex Hormones; Sex Maturation; Sex Steroid Hormones; Sexual Development; Sexual Maturation; Short Consensus Repeat; Signal Transduction; Signal Transduction Systems; Signaling; Somatotropin; Spanish Origin; Stocks, Racial; Strikes; Strikes, Employee; Study models; Suidae; Sushi Domain; Swine; Testing; Texas; Therapeutic Estrogen; Therapeutic GRH; Time; Tissue Growth; Tissues; Universities; Weaning; Work; adipose; adiposity; adolescence (12-20); adult human (21+); base; biological signal transduction; black American; body system, hepatic; bone; bovid; bovine; children; corpulence; corpulency; corpulentia; cow; design; designing; disease/disorder; editorial; feeding; follicle stimulating hormone-releasing factor; gender difference; girls; gonadal steroids; gonadotropin releasing factor; hGHN; heavy metal Pb; heavy metal lead; hispanic community; human puberty; hypothalamic; hypothalamic pituitary gonadal axis; implantation; in utero; in vivo Model; innovate; innovation; innovative; male; meetings; model organism; normal aging; nutrition; obese; obese people; obese person; obese population; ontogeny; organ system, hepatic; pediatric; pilot study; porcine; premature; prevent; preventing; programs; psychosocial; race differences; racial difference; reproductive; reproductive axis; reproductive development; reproductive success; response; sex development; sex steroid; sexual dimorphism (noncellular); socioeconomic; socioeconomically; socioeconomics; somatotropic hormone; suid; teenage; trial regimen; trial treatment; white adipose tissue; yellow adipose tissue; youngster",Endocrine Relationships Preceding Precocious Puberty (pilot),,8107,MPRC,Minority Programs Review Committee,,35,,18393
7753854,S06,GM,5,,01/01/2010,12/31/2010,PAR-04-001,5S06GM044796-19,,NIGMS:98473;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MANGILAO,UNITED STATES,NONE,,779908151,US,GU,96923,UNIVERSITY OF GUAM,"SCHUPP, PETER J;",8085297;,5S06GM044796,09/01/1997,12/31/2010,,Biomedical Research at the University of Guam,,44796,MPRC,Minority Programs Review Committee,,19,98473,
8015286,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM044796-19,0001,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MANGILAO,UNITED STATES,,,779908151,US,GU,96923,UNIVERSITY OF GUAM,"SCHUPP, PETER J;",8085297;,5S06GM044796,,,"Address; Adopted; Agar; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Aquaculture; Arts; Assay; Bacteria; Bioassay; Biologic Assays; Biological Assay; Biomedical Research; Body Tissues; Cancer Center; Cancers; Chemicals; Chemistry; Chromatography, Gas-Liquid-Mass Spectrometry; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Clinical Research; Clinical Study; Collection; Communicable Diseases; Communities; Culture Techniques; DGGE; Detection; Development; Diffusion; Disease; Disorder; Drug Resistance, Multiple; Drug Resistant, Multiple; Drug resistant bacterium; Drugs; Evaluation; GC MS; GCMS; General Practitioners; Generalists; Generalized Growth; Germany; Grant; Growth; Guam; HPLC; High Pressure Liquid Chromatography; Human; Human, General; In Situ; In Vitro; Incubated; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Libraries; Life; Light; Liquid substance; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Fragmentographies; Mass Fragmentography; Medication; Membrane; Methods; Methods and Techniques; Methods, Other; Microorganisms, General; Miscellaneous Antibiotic; Molecular; Monitor; Multi-Drug Resistance; Multidrug Resistance; Pattern; Pharmaceutic Preparations; Pharmaceutical Preparations; Photoradiation; Polymers; Porifera; Production; Programs (PT); Programs [Publication Type]; Research; Resistance to Multi-drug; Resistance to Multidrug; Resistance to Multiple Drug; Resistant to Multiple Drug; Resistant to multi-drug; Resistant to multidrug; Role; Sampling; Science of Chemistry; Screening procedure; Sea Water; Seawater; Series; Simulate; Source; Specialist; Spectrometry, Mass-Gas Chromatography; Spectrum Analysis, Mass-Gas Chromatography; Sponges; Sponges (Zoology); Structure; Symbiosis; Techniques; Temperature; Testing; Tissue Growth; Tissues; Tuberculosis; Universities; Variant; Variation; Work; commensalism; denaturing gradient gel electrophoresis; disease/disorder; disseminated TB; disseminated tuberculosis; drug candidate; drug development; drug discovery; drug resistant bacteria; drug/agent; fluid; fungus; in vitro Assay; in vivo; innovate; innovation; innovative; insight; interest; ion trap mass spectrometry; liquid; malignancy; marine culture; marine natural product; marine organism; mass fragmentometry; membrane structure; microbial; microbial community; microorganism; multi-drug resistant; multidrug resistant; neoplasm/cancer; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; pathogenic bacteria; programs; screening; screenings; social role; tuberculous spondyloarthropathy",New Approaches to Sponge-Microbial Symbioses,,44796,MPRC,Minority Programs Review Committee,,19,,98473
7751328,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,,NIGMS:1657551;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,BIOLOGY,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"MARQUEZ-MAGANA, LETICIA MARIA;",1891628;,5S06GM052588,01/01/1997,12/31/2010,,MBRS SCORE at San Francisco State University,,52588,MPRC,Minority Programs Review Committee,,15,1657551,
8015298,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0001,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"MARQUEZ-MAGANA, LETICIA MARIA;",1891628;,5S06GM052588,,,"Accounting; Active Follow-up; Address; Administrator; Advisory Committees; Apparatus and Instruments; Applications Grants; Archives; Award; Biology; Biomedical Research; Budgets; Committee Members; Communication; Complex; Consultations; Critiques; Curriculum; Data; Data Collection; Data Element; Development; Discipline; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Engineering; Engineerings; Ensure; Equilibrium; Equipment and Supplies; Expenditure; Faculty; Funding; Funding Agency; Funding Source; Grant; Grant Proposals; Grants, Applications; Head; Human Resources; IT Systems; Individual; Information Systems; Information Technology Systems; Infrastructure; Institutional Policy; Investigators; Laboratories; Manpower; Mathematics; Measures; Mediation; Members, Committee; Mentors; Monitor; Negotiating; Negotiation; Peer Review; Pilot Projects; Play; Policies; Policy, Institutional; Position; Positioning Attribute; Preparation; Principal Investigator; Procedures; Process; Productivity; Program Evaluation; Program Reviews; Programs (PT); Programs [Publication Type]; Progress Reports; Publications; R01 Mechanism; R01 Program; RPG; Recruitment Activity; Reporting; Reports, Progress; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Role; Running; SCHED; Salaries; San Francisco; Schedule; Science; Scientific Publication; Scientist; Services; Source; Staging; Structure; Students; Systems, Data; Task Forces; Teaching; Time; TimeLine; Training; Travel; Underrepresented Minority; Universities; Update; Vendor; Wages; Work; Work Load; Workload; Workshop; Writing; balance; balance function; base; college; computer science; experience; falls; follow-up; meetings; member; personnel; pilot study; programs; recruit; repair; repaired; response; social role; success; under-represented minority; underserved minority; web site",Administrative Budget,,52588,MPRC,Minority Programs Review Committee,,15,,198573
8015299,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0003,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"BURRUS, LAURA W.;",8431360;,5S06GM052588,,,"21+ years old; Acylation; Address; Adult; Antibodies; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biologic Assays; Biological Assay; Biological Models; Biology; Body Tissues; Cancers; Cartilage; Cartilagenous Tissue; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Growth in Number; Cell Line; Cell Lines, Strains; Cell Multiplication; Cell Proliferation; Cell Signaling; Cell Survival; Cell Viability; CellLine; Cells; Cellular Proliferation; Collaborations; Colorectal Cancer; Connective Tissue Sarcoma; Cysteine; Data; Diffusion; Dorsal; Drosophila; Drosophila genus; EC 2; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Endoplasmic Reticulum; Enzymes; Equilibrium; Ergastoplasm; Family; Fruit Fly, Drosophila; Functional Imaging; Gene Expression; Generations; Glycoproteins; Goals; Half-Cystine; Half-Life; Half-Lifes; Hematopoietic; Hexadecanoates; Human; Human, Adult; Human, General; Image; Intracellular Communication and Signaling; Knowledge; L-Cysteine; Letters; Life; Ligands; Lipids; Malignant Melanoma; Malignant Mesothelial Neoplasm; Malignant Mesothelial Tumor; Malignant Neoplasm of the Mesothelium; Malignant Neoplasms; Malignant Soft Tissue Neoplasm; Malignant Tumor; Malignant Tumor of the Mesothelium; Malignant Tumor of the Soft Tissue; Malignant mesothelioma; Man (Taxonomy); Man, Modern; Mediating; Membrane; Model System; Models, Biologic; Molecular; Molecular Interaction; Mother Cells; Movement; Muscle; Muscle Tissue; Nerve Cells; Nerve Unit; Neural Cell; Neural tube; Neurocyte; Neurons; Oncogenesis; Palmitates; Pattern; Peptide Signal Sequences; Physiologic Imaging; Play; Porcupines; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Process; Progenitor Cells; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein/Amino Acid Biochemistry, Post-Translational Modification; Protocol; Protocols documentation; Public Health; Reagent; Regulation; Research; Role; San Francisco; Sarcoma of the Soft Tissue and Bone; Sarcoma, Soft Tissue; Signal Peptide; Signal Sequences; Signal Sequences, Peptide; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Protein; Site; Specificity; Stem cells; System; System, LOINC Axis 4; Therapeutic; Tissue Engineering; Tissues; Transferase; Universities; Wnt proteins; Work; adult human (21+); balance; balance function; biological signal transduction; body movement; cell fate specification; cultured cell line; engineered tissue; experiment; experimental research; experimental study; fruit fly; imaging; in vivo; innovate; innovation; innovative; intervention development; malignancy; melanoma; membrane structure; morphogens; neoplasm/cancer; neuronal; palmitoylation; protein signal sequence; public health medicine (field); research study; response; sarcoma; social role; therapeutic development; therapeutic target; therapy development; treatment development; tumorigenesis",Regulation of Wnt Gradient Formation by Palmitoylation,,52588,MPRC,Minority Programs Review Committee,,15,,222614
8015300,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0004,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"CHU, DIANA S;",1907306;,5S06GM052588,,,"Antibodies; Biochemistry; Biology; C elegans; C.elegans; Caenorhabditis elegans; Cannot achieve a pregnancy; Cell Communication and Signaling; Cell Signaling; Chemistry, Biological; Chromatin; Chromosomal, Gene, or Protein Abnormality; Chromosome Condensation; Chromosome Segregation; Chromosomes; Cytogenetic or Molecular Genetic Abnormality; Cytology; DNA; Data; Defect; Deoxyribonucleic Acid; Dephosphorylation; Development; Diagnosis; Diagnostic tests; Difficulty conceiving; EC 2.7; Embryo; Embryonic; FLR; Failure (biologic function); Family member; Fecundability; Fecundity; Fertility; Genes; Genetic Abnormality; Genetic analyses; Goals; Human; Human, General; Infertility; Infertility, Male; Intracellular Communication and Signaling; Kinases; Kinetochores; Laboratories; M Phase; M phase (cell cycle); Male Infertility; Mammalia; Mammals; Mammals, General; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Mechanics; Meiosis; Methods; Methods and Techniques; Methods, Other; Mitosis; Mitosis Stage; Molecular; Molecular Abnormality; Molecular Target; Nematoda; Nematodes; Oocytes; Outcome; Ovocytes; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Protein Dephosphorylation; Protein Phosphatase C; Protein Phosphatase-1; Protein Phosphatase-2A; Protein Phosphorylation; Protein phosphatase; Proteins; Proteomics; Public Health; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Racial Segregation; Regulatory Protein; Research; Research Resources; Resources; Role; San Francisco; Sequence-Specific Posttranscriptional Gene Silencing; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Sperm; Spermatogenesis; Spermatozoa; Techniques; Testing; Time; Transphosphorylases; Universities; Work; base; biological signal transduction; cohesion; experiment; experimental research; experimental study; failure; feeding; gene product; genetic analysis; genetic regulatory protein; human male; infertile; loss of function; male; meiotic; member; mutant; protein function; public health medicine (field); regulatory gene product; reproductive; reproductive success; research study; roundworm; segregation; social role; sperm cell; sperm function; tool; unable to bear children; zoosperm",Defining Roles of PP1 Phosphatases in Sperm Meiosis,,52588,MPRC,Minority Programs Review Committee,,15,,190639
8015301,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0005,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"ESQUERRA, RAYMOND M.;",1975347;,5S06GM052588,,,"5,6,7,8-tetrahydrobiopterin; Absorption; Active Sites; Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt; Affect; Amino Acids; Area; Artificial Erythrocytes; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; BH4; BPH4; Binding; Binding (Molecular Function); Biology; Biomedical Research; Blood Pressure, High; Blood Substitutes; Blood, Artificial; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Carbon Monoxide; Catalysis; Chemistry; Coenzyme II; Complex; DNA Recombination; DNA recombination (naturally occurring); Dehydrogenases; Diabetes Mellitus; EC 1.14.13.39; EDRF Synthase; Electromagnetic, Laser; Electron Transport; Electrons; Elements; Endogenous Nitrate Vasodilator; Endothelium-Derived Growth Factor Synthase; Endothelium-Derived Relaxing Factor; Environment; Enzymes; Erythrocyte Substitutes; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-; Ferroprotoporphyrin; Genetic Recombination; Goals; Guanylyl Cyclase-Activating Factor Synthase; H4B; H4biopterin; Hb SS disease; HbSS disease; Health; Heme; Heme b; Hemoglobin S Disease; Hemoglobin sickle cell disease; Hemoglobin sickle cell disorder; Hypertension; Immune system; In element; Indium; Investigation; Isoforms; Kinetic; Kinetics; Knowledge; L-Arginine,NADPH[{..}]oxygen oxidoreductase (nitric-oxide-forming); Lasers; Ligand Binding; Ligands; Mammalia; Mammals; Mammals, General; Measures; Method LOINC Axis 6; Methodology; Methods; Molecular; Molecular Interaction; Monitor; Mononitrogen Monoxide; N element; N2 element; NAD phosphate; NAD(H) phosphate; NADH phosphate; NADP; NADPH; NADPH-Diaphorase; NO Synthase; NOS 1 protein; Negative Beta Particle; Negatrons; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neural Constitutive Nitric Oxide Synthase; Neurocyte; Neuronal Transmission; Neurons; Nicotinamide-Adenine Dinucleotide Phosphate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide, Endothelium-Derived; Nitric-Oxide Synthetase; Nitrogen; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; O element; O2 element; Organism-Level Process; Organismal Process; Outcome; Oxidoreductase; Oxygen; Oxygenases; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Photolyses; Physiologic; Physiologic Processes; Physiologic pulse; Physiological; Physiological Processes; Physiology; Play; Principal Investigator; Process; Process of absorption; Production; Property; Property, LOINC Axis 2; Protein Isoforms; Proteins; Protoheme; Protoheme IX; Public Health; Pulse; Radiation, Laser; Reaction; Recombination; Recombination, Genetic; Red Cell Substitutes; Reductases; Regulation; Research; Role; San Francisco; Science of Chemistry; Septic Shock; Sickle Cell Anemia; Signaling Molecule; Sites, Active; Source; Spectroscopy; Spectrum Analyses; Spectrum Analysis; Students; THBP; Testing; Therapeutic; Therapeutic Agents; Time; Triphosphopyridine Nucleotide; Universities; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vasodilatation; Vasodilation; Vasorelaxation; Work; absorption; aminoacid; atheromatosis; atherosclerotic vascular disease; base; body system, allergic/immunologic; cofactor; cytokine; cytotoxic; design; designing; diabetes; drug development; electron transfer; endothelial cell derived relaxing factor; ferroheme; gene product; hyperpiesia; hyperpiesis; hypertensive disease; insight; mutant; nNOS enzyme; nano second; nanosecond; neuronal; neuronal nitric oxide synthase; neurotransmission; organ system, allergic/immunologic; oxidation; photolysis; public health medicine (field); sickle cell disease; sickle disease; sicklemia; social role; tetrahydro-6-biopterin; tetrahydrobiopterin; ultraviolet",Fast Kinetic Investigations of Nitric Oxide Synthase,,52588,MPRC,Minority Programs Review Committee,,15,,199391
8015302,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0006,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"HE, ZHENG-HUI ;",8431386;,5S06GM052588,,,"Affect; Animals; Arabidopsis; Arabidopsis thaliana; Bio-Informatics; Biochemical Genetics; Bioinformatics; Blood; Body Tissues; Cell Communication and Signaling; Cell Signaling; Cell Wall; Cell membrane; Cell-Extracellular Matrix; Cells; Communication; Cress, Mouse-ear; Cytoplasmic Membrane; DISSEC; Data; Diet; Dietary Zinc; Dissection; EC 2.7; ECM; Edible Plants; Environment; Extracellular Matrix; Family; Family member; Food Plants; Foundations; Generalized Growth; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Screening; Genetic defect; Genetic, Biochemical; Goals; Growth; Health; Human; Human, General; Intracellular Communication and Signaling; Kinases; Knock-out; Knockout; Knowledge; Left; Link; Man (Taxonomy); Man, Modern; Mediating; Membrane; Micronutrients; Minerals; Molecular; Molecular Genetic; Molecular Genetics; Monitor; Mouse-ear Cress; Mutation; Nutrition; Nutritional Science; Organ; Organism; Phosphotransferases; Plant Model; Plant Roots; Plants; Plants, Edible; Plants, General; Plasma Membrane; Play; Production; Public Health; Publishing; Receptor Protein; Regulation; Reproduction; Research; Reticuloendothelial System, Blood; Role; San Francisco; Science of nutrition; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Solid; Source; Testing; Tissue Growth; Tissues; Transgenic Organisms; Transphosphorylases; Universities; Work; Wound Healing; Wound Repair; Zinc; Zinc decreased; Zinc deficiency; Zinc low; Zn deficiency; Zn element; Zn levels low; Zn++ low; base; biological signal transduction; experience; extracellular; genome mutation; improved; innovate; innovation; innovative; living system; loss of function; low Zinc level; member; membrane structure; mutant; nutrition; ontogeny; plasmalemma; public health medicine (field); receptor; response; root; screening; screenings; social role; tissue repair; transgenic; zinc binding ligand; zinc transporter; zinc-binding protein",Role of a Cell Wall-Associated Kinase in Zinc Sensing,,52588,MPRC,Minority Programs Review Committee,,15,,198059
8015303,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0007,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"SIMONIS, URSULA ;",7674310;,5S06GM052588,,,"Actinotherapy; Adjuvant; Affinity; Age related macular degeneration; Al element; Aluminum; Apoptosis; Apoptosis Pathway; Apoptotic; Body Tissues; Breast; Cancer of Bladder; Cancer of Urinary Bladder; Cancers; Cardiac artery; Cause of Death; Cell Death; Cell Death, Programmed; Cells; Cellular injury; Cessation of life; Characteristics; Clinical; Coloring Agents; Communicable Diseases; Communities; Complex; Coronary artery; Death; Detection; Development; Diagnosis; Disease; Disorder; Drug Design; Drugs; Dyes; Esophagus; Eye; Eyeball; Ga element; Gallium; Gastrointestinal Tract, Esophagus; Goals; Head and Neck; Head and neck structure; Heart artery; In Vitro; In element; Indium; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Lead; Lesion; Light Therapy; Lung; Maculopathy, Age-Related; Malignant; Malignant - descriptor; Malignant Bladder Neoplasm; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Bladder; Malignant neoplasm of urinary bladder; Measures; Medication; Mitochondria; Modality; Molecular; O element; O2 element; Organelles; Outcome; Oxygen; Partition Coefficient; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Photochemotherapy; Photodynamic Therapy; Photoradiation Therapy; Photosensitizers; Photosensitizing Agents; Phototherapy; Pigments; Porphyrins; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocols, Treatment; Public Health; RGM; Radiation, Visible; Radiation, Visible Light; Reaction; Regimen; Reporting; Research; Respiratory System, Lung; Role; San Francisco; Scheme; Scientist; Screening procedure; Singlet Dioxygen; Singlet Oxygen; Skin; Testing; Therapeutic; Tissues; Treatment Efficacy; Treatment Protocols; Treatment Regimen; Treatment Schedule; United States; Universities; Urinary Bladder Malignant Tumor; VESCL; Vesicle; Visible Light; Visible Radiation; Zinc; Zn element; amphiphilicity; base; cancer cell; cell damage; cell injury; chlorin; clinical practice; conference; conventional therapy; cytotoxic; design; designing; disease/disorder; drug candidate; drug/agent; empowered; fight against; fluorescence imaging; heavy metal Pb; heavy metal lead; improved; interstitial; malignancy; metal complex; minimally invasive; mitochondrial; necrocytosis; neoplasm/cancer; neoplasm/cancer photoradiation therapy; neoplastic; oxidative damage; palliative; pathway; phthalocyanine; porphyrin a; programs; public health medicine (field); pulmonary; response; screening; screenings; senile macular disease; skin lesion; social role; symposium; therapeutic efficacy; therapeutically effective; tumor; uptake; water solubility; weapons",Porphyrinic Sensitizers Aimed at Mitochondrial Targeting,,52588,MPRC,Minority Programs Review Committee,,15,,240286
8015304,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0008,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"WU, WEIMING ;",8431426;,5S06GM052588,,,"1,3 diazine; 3-ribofuranosylorotic acid; 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-; 5'-Uridylic acid; 5-(dihydrogen phosphate)orotidine; 6-carboxyuridine; Accounting; Affinity; Anabolism; Antiviral Agents; Antiviral Drugs; Antivirals; Binding; Binding (Molecular Function); Binding Sites; Carboxy-Lyases; Catalysis; Chemistry, Organic; Chemotherapy Protocol; Chemotherapy Regimen; Chemotherapy, Cancer, General; Chemotherapy-Oncologic Procedure; Cocarboxylase; Combination Chemotherapy Regimen; Combining Site; D-Ribose; DNA; Decarboxylases; Decarboxylation; Deoxyribonucleic Acid; Electrons; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Goals; H+ element; Hydrogen Ions; Knowledge; Lead; Measures; Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids; Modeling; Molecular Interaction; Negative Beta Particle; Negatrons; Nucleosides; Nucleotide Synthesis; Nucleotides; Organic Chemistry; Organism; Outcome; Pathway interactions; Pb element; Play; Protons; Public Health; Pyridoxal 5-Phosphate; Pyridoxal Phosphate; Pyridoxal-P; Pyrimidine; Pyrimidine Antagonist; Pyrimidines; Quimioterapia; Reaction; Reactive Site; Reporting; Research; Ribose; Role; San Francisco; Structure; Study models; TPP; Testing; Therapeutic; Thiamine Diphosphate; Thiamine Pyrophosphate; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, P,P'-dioxide; UMP; Universities; Uridine 5'-Monophosphate; Uridine Monophosphate; Uridylic Acid; Work; alkalinity; analog; base; basicity; biosynthesis; cancer chemotherapy; chemotherapy; cofactor; design; designing; drug candidate; enzyme model; enzyme structure; functional group; heavy metal Pb; heavy metal lead; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; interest; living system; novel; nucleic acid biosynthesis; nucleotide metabolism; orotidine; orotidine 5'-monophosphate; orotidylic acid; pathway; public health medicine (field); pyrimidine analog; reaction rate; social role",Mechanism of Orotidine-5'-Monophosphate Decarboxylase,,52588,MPRC,Minority Programs Review Committee,,15,,186649
8015305,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0009,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"ARSUAGA, FRANCISCO JAVIER ;",8443956;,5S06GM052588,,,"Aberrant Chromosome; Abnormalities, Chromosomal; Algorithms; Allergy; Assay; Binding; Binding (Molecular Function); Binding Proteins; Bioassay; Biologic Assays; Biological Assay; Cancer Induction; Cancer Radiotherapy; Cancers; Cell Nucleus; Cells; Cellular injury; Chemicals; Chromatin; Chromatin Assembly; Chromatin Modeling; Chromosomal Aberrations; Chromosomal Alterations; Chromosomal Instability; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome Instability; Chromosome abnormality; Chromosomes; Collaborations; Computer Programs; Computer Simulation; Computer software; Computerized Models; Computing Methodologies; Cytogenetic Aberrations; Cytogenetic Abnormalities; DNA Double Strand Break; DNA Recombination; DNA Sequence Rearrangement; DNA recombination (naturally occurring); DNA repair protein; Data; Data Set; Dataset; Diffuse; Diffusion; Double Strand Break Repair; Eukaryote; Eukaryotic Cell; Event; Exposure to; Fluorescence; Fluorescence Photobleaching Recovery; Fluorescence Recovery After Photobleaching; Free Radicals; Genetic Condition; Genetic Diseases; Genetic Recombination; Genome; Genome Instability; Genomic Instability; Goals; H2A Histone Family, Member X; H2A histone family, member X protein, human; H2A.X protein, human; H2A/X; H2AFX; H2AFX protein, human; H2AX; H2AX protein, human; Hereditary Disease; Histone H2A.X; Histone H2AX; Histones; Hypersensitivity; Individual; Investigators; Label; Ligand Binding Protein; Malignant Neoplasms; Malignant Tumor; Mathematical Model Simulation; Mathematical Models and Simulations; Measures; Metabolic; Modeling; Models, Computer; Molecular Disease; Molecular Interaction; Nucleus; Occupational Exposure; Phosphorylation; Photobleaching; Physics; Play; Polymers; Position; Positioning Attribute; Predisposition; Process; Property; Property, LOINC Axis 2; Protein Phosphorylation; Proteins; Protocol; Protocols documentation; Public Health; Publishing; Radiation; Radiation Biology; Radiation Sensitivity; Radiation Tolerance; Radiation therapy; Radiobiology; Radiosensitivity; Radiotherapeutics; Radiotherapy; Reaction; Rearrangement; Recombination; Recombination, Genetic; Recruitment Activity; Research; Research Personnel; Researchers; Role; San Francisco; Simulate; Simulation, Computer based; Sister Chromatid; Software; Susceptibility; Testing; Universities; Work; base; biodosimetry; cancer genetics; cancer progression; cancer risk; carcinogenesis; cell damage; cell injury; cohesin; cohesion; computational methodology; computational methods; computational modeling; computational models; computational simulation; computer based models; computer methods; computer program/software; computerized modeling; computerized simulation; develop software; developing computer software; eukaryotida; experiment; experimental research; experimental study; flexibility; gene product; genetic disorder; hereditary disorder; human H2AX protein; improved; in silico; interest; irradiation; malignancy; neoplasm progression; neoplasm/cancer; neoplastic progression; public health medicine (field); ray (radiation); recruit; repair; repaired; research study; response; social role; software development; tumor; tumor progression; virtual simulation",Computer Modeling of DNA Double-Strand Break Repair (pilot),,52588,MPRC,Minority Programs Review Committee,,15,,73780
8015306,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0010,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"STILLMAN, JONATHON ;",8443906;,5S06GM052588,,,"(S)-Lactate[{..}]NAD+ oxidoreductase; Acidosis; Active Sites; Affect; Amino Acids; Animal Model; Animal Models and Related Studies; Articulation; Body Tissues; Brachyura; Cancer Treatment; Cancerous; Cancers; Cardiac; Cell division; Cells; Characteristics; Claw; Co-Immunoprecipitations; Complex; Crabs; Crabs, Short-Tailed; Crabs, True; Crustacea; Data; Development; EC 1.1.1.27; EST Library; Elements; Enzymes; Fingerprint; Gene Expression; Gene Expression Microarray Analysis; Gene Proteins; GeneHomolog; Generations; Genes; Genes, Regulator; Genome; Glycolysis; Goals; HIF 1; HIF-1 protein; HIF1; HIF1 protein; Homolog; Homologous Gene; Homologue; Hypoxia; Hypoxia Inducible Factor; Hypoxic; Institutes; Ischemia; Isoforms; Joints; L-Lactate Dehydrogenase; L-Lactic Acid Dehydrogenase; LDH; Lactate Dehydrogenase; Lactic acid; Lead; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Medicine; Metabolic; Modification; Molecular; Molecular Genetic; Molecular Genetics; Muscle; Muscle Tissue; NAD-Lactate Dehydrogenase; Nerve Tissue; Nervous Tissue; Oxygen Deficiency; Pathway interactions; Patients; Pb element; Peptides; Phenotype; Physiologic; Physiological; Post-Translational Modifications; Post-Translational Protein Processing; Posttranslational Modifications; Protein Gene Products; Protein Isoforms; Protein Modification; Protein Modification, Post-Translational; Protein Processing, Post-Translational; Protein Processing, Posttranslational; Protein Region; Protein/Amino Acid Biochemistry, Post-Translational Modification; Proteins; Public Health; RT-PCR; RTPCR; Recovery; Regulator Genes; Relative; Relative (related person); Research; Reverse Transcriptase Polymerase Chain Reaction; San Francisco; Science of Medicine; Sites, Active; Solid Neoplasm; Solid Tumor; Structure; System; System, LOINC Axis 4; Testing; Therapeutic Agents; Tissues; Transcriptional Regulatory Elements; Tumor Cell; Universities; Variant; Variation; Work; aminoacid; anticancer therapy; base; cDNA Arrays; cDNA Microarray; cancer therapy; chemotherapeutic agent; expectation; gene product; heavy metal Pb; heavy metal lead; hypoxia inducible factor 1; improved; in vivo; innovate; innovation; innovative; lactic acid dehydrogenase; malignancy; model organism; modulator protein; neoplasm/cancer; neoplastic cell; new therapeutics; next generation therapeutics; novel; novel therapeutics; pathway; phosphatase inhibitor 2; phosphoprotein phosphatase inhibitor-2; polyclonal antibody; protein phosphatase inhibitor-2; protein protein interaction; protein structure; public health medicine (field); regulatory gene; response; reverse transcriptase PCR; trans acting element; tumor; tumor growth",Intrinsic and Extrinsic Modulators of Protein Stability (pilot),,52588,MPRC,Minority Programs Review Committee,,15,,73780
8015307,S06,GM,5,,01/01/2010,12/31/2010,,5S06GM052588-15,0011,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"VAZQUEZ, MARIEL ;",8443929;,5S06GM052588,,,"2 Dimensional Gel Electrophoresis; Address; Anti-Bacterial Agents; Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antibacterial Agents; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Arts; Assay; Bacterial Typing; Bacteriophages; Bioassay; Biologic Assays; Biological Assay; Cancer Drug; Capsid; Catenanes; Cell Death; Cell Function; Cell Process; Cell division; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapeutic Agents, Neoplastic Disease; Chromosomes; Circular DNA; Computer Analysis; Computer Simulation; Computerized Models; Computers; DNA; DNA Molecular Biology; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerase II; DNA Topoisomerase IV; DNA Topoisomerases II, Eukaryotic; DNA Topoisomerases, Type II; DNA Topoisomerases, Type II, Eukaryotic; DNA Type 2 Topoisomerase; DNA, Circular; Data; Deoxyribonucleic Acid; Effectiveness; Electron Microscopy; Electrophoresis, Gel, 2-D; Electrophoresis, Gel, 2D; Electrophoresis, Gel, Two-Dimensional; Ensure; Environment; Enzymes; Equilibrium; Funding; Goals; History; Human; Human, General; International; Investigators; Lead; Length; Life; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mathematics; Measures; Mentors; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Computer; Molecular; Molecular Biology; Monte Carlo Method; Organism; Paste substance; Pastes; Pathway interactions; Pb element; Phages; Physics; Polymers; Process; Public Health; Racial Segregation; Recording of previous events; Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Sampling; San Francisco; Scientist; Simulate; Simulation, Computer based; Solutions; Students; Subcellular Process; Techniques; Testing; Theoretical Studies; Time; Topo II; Topo IV; Topoisomerase; Topoisomerase II; Topoisomerase IV; Topoisomerase-II Inhibitor; Topoisomerases II, Eukaryotic; Tumor-Specific Treatment Agents; Typing, Bacterial; Underrepresented Minority; Universities; Validation; Woman; Work; Yeasts; anti-bacterial; anti-microbial agent; anti-microbial drug; antibacterial; anticancer agent; anticancer drug; antimicrobial agent; antimicrobial drug; bacterial virus; balance; balance function; base; coat (nonenveloped virus); computational analysis; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; in silico; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; interdisciplinary approach; interest; living system; necrocytosis; novel; pathway; public health medicine (field); research study; segregation; simulation; social role; success; theories; under-represented minority; underserved minority; virtual simulation",Computer Analysis of DNA Unknotting by Topoisomerase (pilot),,52588,MPRC,Minority Programs Review Committee,,15,,73780
7769887,S06,GM,5,,02/01/2010,01/31/2011,PAR-04-001,5S06GM073765-04,,NIGMS:61022;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DOVER,UNITED STATES,BIOLOGY,00,114337629,US,DE,19901,DELAWARE STATE UNIVERSITY,"DAVIS, LEONARD GEORGE;",8864451;,5S06GM073765,02/05/2007,01/31/2011,,Building Research Capacity for the 21st Century: an MBRS SCORE Proposal,,73765,MPRC,Minority Programs Review Committee,,4,61022,
8019004,S06,GM,5,,02/01/2010,01/31/2011,,5S06GM073765-04,0001,,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DOVER,UNITED STATES,,00,114337629,US,DE,19901,DELAWARE STATE UNIVERSITY,"HARRINGTON, MELISSA A;",8864458;,5S06GM073765,,,"Algorithms; Analysis, Data; Behavior; Biological Models; Brain; Cell Communication and Signaling; Cell Signaling; Cells; Cerebrum; Computer Architectures; Computer Simulation; Computerized Models; Connectionist Models; Data; Data Analyses; Decision Making; Development; EEG; Electrodes; Electroencephalography; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Epithelium; Frequencies (time pattern); Frequency; Ganglia; Ganglion Cysts; Ganglionic Cysts; Ganglions; Human; Human, General; Individual; Intracellular Communication and Signaling; Invertebrata; Invertebrates; Invertebrates, General; Man (Taxonomy); Man, Modern; Mathematical Biology; Mathematical Model Simulation; Mathematical Models and Simulations; Methods and Techniques; Methods, Other; Model System; Modeling; Models, Biologic; Models, Computer; Myxoid cyst; NRVS-SYS; Nerve; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Ganglion; Neural Network Models; Neural Network Simulation; Neural Networks (Computer); Neurologic Body System; Neurologic Organ System; Neurophysiology / Electrophysiology; Pattern; Perceptrons; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Science of neurophysiology; Sense Organs; Sensory; Sensory Process; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Snails; Sorting - Cell Movement; Source; Stimulus; Students; Techniques; Technology; Underrepresented Minority; biological signal transduction; cell type; computational modeling; computational models; computational network modeling; computational simulation; computer based models; computerized modeling; computerized simulation; experiment; experimental research; experimental study; in silico; independent component analysis; insight; network architecture; network models; neural; neural model; neural network (computer simulation of nervous system); neural patterning; neurophysiology; programs; relating to nervous system; research study; response; sorting; tool; under-represented minority; underserved minority; virtual simulation",Recording Snail Brain Activity with a Multi-electrode Array,,73765,MPRC,Minority Programs Review Committee,,4,,61022
7749947,SC1,GM,5,,01/01/2010,12/31/2010,PAR-08-026,5SC1GM082718-02,,NIGMS:252875;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN ANTONIO,UNITED STATES,CHEMISTRY,23,800189185,US,TX,782490600,UNIVERSITY OF TEXAS SAN ANTONIO,"ZHAO, CONG-GUI ;",7866001;,5SC1GM082718,01/01/2009,01/01/2012,"3-hydroxybutanal; 3-hydroxybutyraldehyde; Acids; Adverse effects; Affect; Aldehydes; Amino Acids; Anti-Bacterial Agents; Antibacterial Agents; Applications Grants; Area; Benign; Biological; C element; Cancers; Carbon; Chemistry, Pharmaceutical; Collaborations; Data; Development; Drug Industry; Electrons; Environment; Enzyme Antagonist; Enzyme Inhibitor; Enzyme Inhibitor Agent; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Funding; Goals; Grant; Grant Proposals; Grants, Applications; Hypophosphorous Acids; Imines; In Situ; Industry, Pharmaceutic; Investigation; Ketones; L-Proline; Malignant Neoplasms; Malignant Tumor; Medicinal Chemistry; Method LOINC Axis 6; Methodology; Methods; NIH; National Institutes of Health; National Institutes of Health (U.S.); Negative Beta Particle; Negatrons; Pharmaceutic Chemistry; Pharmaceutical Agent; Pharmaceutical Chemistry; Pharmaceutical Industry; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphinic Acids; Problem Solving; Productivity; Proline; Property; Property, LOINC Axis 2; R01 Mechanism; R01 Program; RPG; Reaction; Research; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Research Support; Screening procedure; Secure; Staging; Structure; Students; Testing; Training; Treatment Side Effects; United States National Institutes of Health; Withdrawal; Work; acetaldol; aldol; aminoacid; analog; anti-bacterial; antibacterial; base; carbonyl group; career; catalyst; cost; design; designing; enantiomer; malignancy; neoplasm/cancer; novel; research facility; screening; screenings; side effect; success; therapy adverse effect; treatment adverse effect",Enantioselective Synthesis of Phosphinate Derivatives,,82718,ZGM1,Special Emphasis Panel,,2,252875,
7743085,SC1,GM,5,,01/01/2010,12/31/2010,PAR-08-026,5SC1GM086240-02,,NIGMS:326430;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN JUAN,UNITED STATES,CHEMISTRY,,143960193,US,PR,009311790,UNIVERSITY OF PUERTO RICO RIO PIEDRAS,"GRIEBENOW, KAI H;",6618412;,5SC1GM086240,01/01/2009,12/31/2012,"Adsorption; Adverse effects; Aggregated Data; Aggregation, Data; Air; Applications Grants; Binding; Binding (Molecular Function); Biochemical; Biological; Blood capillaries; Calorimetry, Differential Scanning; Capillaries; Capillary; Capillary, Unspecified; Characteristics; Chemicals; Computing Methodologies; DNA Endonuclease; DNase; DNase I; Data; Data Aggregation; Deoxyribonuclease I; Development; Devices; Dextrans; Differential Scanning Calorimetry; Differential Thermal Analysis, Calorimetric; Disaccharides; Drug Formulations; Electrophoresis; Encapsulated; Environment; Enzyme Kinetics; Enzyme Stability; Enzymes; Equipment; Event; Exposure to; FTIR; FTIR spectroscopy; Fluorescence Spectroscopy; Formulation; Formulations, Drug; Fourier transform infrared spectroscopy; Fractionation, Electrophoretic; Gases; Glycans; Glycoconjugates; Goals; Grant Proposals; Grants, Applications; Humidity; Humulin R; Hydrophobicity; Immune; Infusion; Infusion Pumps; Infusion procedures; Infusors; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Kinetic; Kinetics; Knowledge; Light; Liquid substance; Longitudinal Studies; Lung; Measurement; Measures; Mechanics; Medical; Metabolic Glycosylation; Methods; Methods and Techniques; Methods, Other; Microbeads; Microscopy; Microspheres; Modeling; Models, Molecular; Molecular; Molecular Dynamics Simulation; Molecular Interaction; Molecular Models; Monosaccharides; Nature; Novolin R; Nucleic Acid Biochemistry, Molecular Modeling; Organic Solvents; Organic solvent product; Pancreatic DNase; Perfusion Pumps; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Photoradiation; Plastics; Polyesters; Polymers; Polysaccharides; Powder dose form; Powders; Prevention; Productivity; Property; Property, LOINC Axis 2; Protein Dynamics; Protein Glycosylation; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Pump; Reaction; Research; Residual; Residual state; Respiratory System, Lung; Solid; Spectroscopy, Fluorescence; Spectroscopy, Fourier Transform Infrared; Stress; Structural Protein; Structure; Surface; Techniques; Temperature; Testing; Therapeutic; Thermodynamic; Thermodynamics; Thymonuclease; Time; Treatment Side Effects; Work; base; capillary; chemical stability; chymotrypsin; clinical applicability; clinical application; computational methodology; computational methods; computer methods; design; designing; dextran; experiment; experimental research; experimental study; fluid; gene product; glycosylation; improved; insight; insoluble aggregate; liquid; liquid formulation; long-term study; molecular dynamics; molecular modeling; nano materials; nanomaterials; network models; new technology; novel; prevent; preventing; protein aggregate; protein structure; protein structure function; pulmonary; research study; side effect; simulation; solid state; therapeutic protein; therapy adverse effect; thermolability; thermostability; treatment adverse effect",Chemical Protein Glycosylation,,86240,ZGM1,Special Emphasis Panel,,2,326430,
7746413,SC1,GM,5,,01/01/2010,12/31/2010,PAR-08-026,5SC1GM086268-03,,NIGMS:269050;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,PHYSICS,10,620127691,US,NY,11210,BROOKLYN COLLEGE,"BOUTIS, GREGORY ;",10233401;,5SC1GM086268,01/01/2009,12/31/2012,"Anisotropy; Atomic Force Microscope; Atomic Force Microscopy; Behavior; Biomolecular Nuclear Magnetic Resonance; Biopolymers; Body Tissues; Cell Communication and Signaling; Cell Nucleus; Cell Signaling; Cities; Collaborations; Communities; Coupled; Deuterium; Development; Disease; Disorder; Educational workshop; Elastic Fiber; Elasticity; Elastin; Elastin Fiber; Faculty; Force Microscopy; Fruit; Funding; Goals; Grant; H+ element; H2 isotope; Heart; Hydration; Hydration status; Hydrogen Ions; Hydrogen Oxide; Image; Institution; Intracellular Communication and Signaling; Investigation; Investigators; Journals; Knowledge; Laboratories; Life; MR Imaging; MR Tomography; MRI; Magazine; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Mechanics; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Methods and Techniques; Methods, Other; Microscopy; Microscopy, Atomic Force; Modeling; Molecular; Motion; NIH; NMR Imaging; NMR Tomography; NMR, Biomolecular; National Institutes of Health; National Institutes of Health (U.S.); Nature; New York; Nuclear; Nuclear Magnetic Resonance; Nuclear Magnetic Resonance Imaging; Nuclear Magnetic Resonance, Biomolecular; Nucleus; Organism; Peer Review; Physiologic pulse; Play; Probability; Programs (PT); Programs [Publication Type]; Progress Reports; Proteins; Protons; Publishing; Pulse; Reports, Progress; Research; Research Personnel; Researchers; Resolution; Role; SIS; Sampling; Scanning Force Microscopy; Scheme; Signal Transduction; Signal Transduction Systems; Signaling; Sister; Slice; Spinal Column; Spine; Staging; Stress; Structure; Structure-Activity Relationship; Surface; Surface Tension; Techniques; Temperature; Testing; Tissues; United States National Institutes of Health; Universities; Vertebral column; Water; Work; Workshop; Writing; Zeugmatography; backbone; base; biological signal transduction; burden of disease; burden of illness; chemical structure function; college; conference; density; dietary fruit; disability; disease burden; disease/disorder; experience; experiment; experimental research; experimental study; forging; fundamental research; gene product; imaging; living system; meetings; member; novel; programs; quantum; radiofrequency; research study; skills; social role; solid state; solid state nuclear magnetic resonance; structure function relationship; symposium; theories; years of life lost to disability; years of life lost to disease",Probing dynamics of water in elastin by q-space imaging and multiple quantum NMR,,86268,ZGM1,Special Emphasis Panel,,3,269050,
7742628,SC1,GM,5,,01/01/2010,12/31/2010,PAR-08-026,5SC1GM086344-02,,NIGMS:319500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,POMONA,UNITED STATES,BIOLOGY,38,028929438,US,CA,917682557,CALIFORNIA STATE POLY U POMONA,"ESKANDARI, SEPEHR ;",6602709;,5SC1GM086344,01/01/2009,12/31/2012,"4-Aminobutanoic Acid; 4-Aminobutyric Acid; Address; Affinity; Aminalon; Aminalone; Aminobutyric Acids; Anti-epileptic; Antiepileptic Agents; Antiepileptic Drugs; Antiepileptics; Apoplexy; Applications Grants; Assay; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biologic Assays; Biological Assay; Body Tissues; Brain; Butanoic acid, 4-amino-; Cell Communication and Signaling; Cell Signaling; Cell membrane; Cells; Central Nervous System; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Charge; Chemosensitization; Chemosensitization/Potentiation; Co-Transporters; Combining Site; Computer Simulation; Computerized Models; Cytoplasmic Membrane; Dependence; Development; Docking; Drugs; Educational workshop; Electron Microscopy; Electrons; Encephalon; Encephalons; Ensure; Epilepsy; Epileptic Seizures; Epileptics; Event; Exhibits; Experimental Designs; Experimental Models; Experimental Models, Other; Family; Family member; Freeze Fracturing; Freeze Fracturings; Funding; Future; GABA; GABA Transporter 1; GABA transporter 3; GAT; GAT-1 transporter; GAT-3 transporter; GAT1 transporter; GAT3 transporter; Genetic Engineering of Proteins; Genetics-Mutagenesis; Glean; Goals; Grant; Grant Proposals; Grants, Applications; Heart; Homology Modeling; Individual; Intracellular Communication and Signaling; Investigators; Isoforms; Kinetic; Kinetics; Knowledge; L-Leucine; L-glutamic acid, polymer with L-alanine & L- tyrosine; Lead; Leucine; Leucine, L-Isomer; Mathematical Model Simulation; Mathematical Models and Simulations; Measurement; Measures; Mediating; Medication; Membrane; Methods; Methods and Techniques; Methods, Other; Microscopic; Modeling; Models, Computer; Models, Experimental; Models, Molecular; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Molecular Models; Mutagenesis; Mutagenesis, Site-Directed; N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid; NIGMS; NRVS-SYS; Na element; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Negative Beta Particle; Negatrons; Nerve; Nerve Impulse Transmission; Nerve Transmission; Nerve Transmitter Substances; Nervous; Nervous System; Nervous System, Brain; Nervous System, CNS; Nervous system structure; Neuraxis; Neurologic Body System; Neurologic Organ System; Neuronal Transmission; Neurotransmitters; Nucleic Acid Biochemistry, Molecular Modeling; Oocytes; Ovocytes; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacology; Phenotype; Physiologic; Physiological; Physiology; Plasma Membrane; Platanna; Play; Potentiation; Principal Investigator; Property; Property, LOINC Axis 2; Protein Engineering; Protein Isoforms; Protein Trafficking; Protein/Amino Acid Biochemistry, Molecular Modeling; Publications; Reactive Site; Receptor Protein; Research; Research Personnel; Researchers; Resolution; Role; SLC6A11 protein; Scientific Publication; Screening procedure; Seizure Disorder; Shapes; Signal Transduction; Signal Transduction Systems; Signaling; Simulation, Computer based; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sodium; Specificity; Stroke; Structure; Synapses; Synaptic; System; System, LOINC Axis 4; Targeted DNA Modification; Targeted Modification; Techniques; Temperature; Therapeutic; Time; Tissues; Traffickings, Protein; V (voltage); Vascular Accident, Brain; Work; Workshop; Writing; Xenopus laevis; analog; biological signal transduction; brain attack; cerebral vascular accident; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; design; designing; drug/agent; epilepsia; epileptiform; epileptogenic; experiment; experimental research; experimental study; extracellular; gamma-Aminobutyric Acid; glutamic acid-alanine-tyrosine terpolymer; heavy metal Pb; heavy metal lead; in silico; inhibitor; inhibitor/antagonist; insight; meetings; membrane structure; molecular modeling; mutant; neurotransmission; novel; pharmacophore; plasmalemma; poly(Glu(60)Ala(30)Tyr(10)); poly(L-glutamic acid(60)-L-alanine(30)-L-tyrosine(10)); prevent; preventing; protein transport; receptor; research study; screening; screenings; social role; solute carrier family 6 (neurotransmitter transporter, GABA), member 1; solute carrier family-6 (neurotransmitter transporter, GABA), member 11; stroke; symporter; symporter (molecular); tiagabine; virtual simulation; voltage",Molecular Physiology of y-Aminobutyric Acid Transporters,,86344,ZGM1,Special Emphasis Panel,,2,319500,
7760539,SC2,AI,5,,02/01/2010,01/31/2011,PAR-08-027,5SC2AI083925-02,,NIGMS:145035;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NASHVILLE,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,05,041438185,US,TN,37208,MEHARRY MEDICAL COLLEGE,"NDE, PIUS N;",9037808;,5SC2AI083925,02/01/2009,01/31/2012,"Abscission; Affect; Affinity Chromatography; American Trypanosomiasis; American trypanosome; Amino Acids; Applications Grants; Area; Award; Binding; Binding (Molecular Function); Biology; Biosynthetic Proteins; Blood; Body Tissues; Cardiac; Cardiac Diseases; Cardiac Disorders; Cardiac infarction; Cardiovascular Pathology; Causality; Cell Communication; Cell Interaction; Cell-Extracellular Matrix; Cell-to-Cell Interaction; Cells; Chagas Disease; Chromatography, Affinity; Chronic; DNA; Data; Deoxyribonucleic Acid; Development; Disease; Disorder; ECM; Etiology; Excision; Expression Profiling; Expression Signature; Extirpation; Extracellular Matrix; Extracellular Matrix Proteins; Faculty; Funding; Gene Expression; Genes; Goals; Grant; Grant Proposals; Grants, Applications; Heart; Heart Diseases; Individual; Infection; Infection prevention; International; Intervention; Intervention Strategies; Investigation; Investigators; Journals; Knowledge; Laboratories; Lead; Link; MALD-MS; MALDI; MALDI-MS; MALDI-TOF Mass Spectrometry; Magazine; Mammals, Mice; Matrix-Assisted Laser Desorption Ionization Time-of-Flight MS; Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry; Mice; Minority; Modeling; Molecular; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Molecular Target; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Murine; Mus; Myocardial Infarct; Myocardial Infarction; Oligosaccharides; Parasites; Pathogenesis; Pathology; Pb element; Play; Position; Positioning Attribute; Post-Transcriptional Gene Silencing; Post-Transcriptional Gene Silencings; Postdoc; Postdoctoral Fellow; Posttranscriptional Gene Silencing; Posttranscriptional Gene Silencings; Prevent infection; Process; Programs (PT); Programs [Publication Type]; Proteins; Public Health; Publications; Publishing; Quelling; RNA Interference; RNA Silencing; RNA Silencings; RNAi; Receptor Cell; Receptor Protein; Recombinant Proteins; Removal; Research; Research Associate; Research Personnel; Researchers; Reticuloendothelial System, Blood; Role; Schools, Medical; Science; Scientific Publication; Scientist; Secure; Sequence-Specific Posttranscriptional Gene Silencing; Series; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Staging; Surface; Surgical Removal; T-Stage; T. cruzi; THBS1; THBS1 gene; TSP; TSP Gene; TSP-1; TSP1; TSP1 Gene; Testing; Thrombospondin 1; Thrombospondin-1 Gene; Tissues; Training; Trypanosoma; Trypanosoma cruzi; Trypanosome; Trypanosomiasis, South American; Tumor stage; Universities; Wild Type Mouse; Wisconsin; Work; affinity purification; aminoacid; base; cardiac infarct; coronary attack; coronary infarct; coronary infarction; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experiment; experimental research; experimental study; gene product; graduate student; heart attack; heart cell; heart disorder; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; in vivo; inhibitor; inhibitor/antagonist; innovate; innovation; innovative; interest; interventional strategy; matrix assisted laser desorption ionization; medical schools; meetings; microbial; molecuar profile; molecular signature; mouse model; new approaches; novel; novel approaches; novel strategies; novel strategy; pathogen; post-doc; post-doctoral; prevent; preventing; programs; public health medicine (field); public health relevance; receptor; receptor binding; research study; resection; social role; sugar",Novel trypanosome receptor for thrombospondin-1,,83925,ZGM1,Special Emphasis Panel,,2,145035,
7755049,SC2,GM,5,,02/01/2010,01/31/2011,PAR-08-027,5SC2GM082336-02,,NIGMS:154000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,BIOLOGY,15,603503991,US,NY,10031,CITY COLLEGE OF NEW YORK,"JANAKIRAMAN, ANURADHA ;",8870977;,5SC2GM082336,02/01/2009,01/31/2012,"Address; Amino Acids; Anti-Bacterial Agents; Antibacterial Agents; Assay; Bacteria; Bacterial Gene Proteins; Bacterial Proteins; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biological Models; Catabolic Gene Activators; Catabolite Activator Protein; Catabolite Gene Activator Proteins; Cell Function; Cell Process; Cell division; Cell membrane; Cell physiology; Cells; Cellular Function; Cellular Matrix; Cellular Physiology; Cellular Process; Co-Immunoprecipitations; Complex; Cyclic AMP Receptor Protein; Cytokinesis; Cytoplasmic Division; Cytoplasmic Membrane; Cytoskeletal Proteins; Cytoskeletal System; Cytoskeleton; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; E coli; Escherichia coli; Essential Genes; Future; Gene Combinations; Gene Products, Bacterial; GeneHomolog; Generations; Genes, Essential; Genetic Screening; Genetics-Mutagenesis; Goals; Homolog; Homologous Gene; Homologue; Human; Human, General; Laboratories; Libraries; Life; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Membrane; Membrane Proteins; Membrane-Associated Proteins; Methods; Model System; Models, Biologic; Molecular; Molecular Biology, Mutagenesis; Molecular Interaction; Mothers; Murein; Mutagenesis; Nature; Organism; Pattern; Peptidoglycan; Periplasmic Space; Plasma Membrane; Play; Process; Proteins; Regulation; Regulator Proteins, Catabolite; Reporter; Role; Salmonella; Shigella; Site; Subcellular Process; Surface Proteins; Tubulin; Two Hybrid; Vibrio; Work; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yersinia; aminoacid; anti-bacterial; anti-microbial agent; anti-microbial drug; antibacterial; antimicrobial agent; antimicrobial drug; base; cAMP Receptor Proteins; cell envelope; daughter cell; gene product; genome-wide; insight; intracellular skeleton; living system; membrane structure; mutant; novel; pathogen; periplasm; periplasmic; plasmalemma; premature; protein complex; protein protein interaction; social role; spatiotemporal; yeast two hybrid system",Characterization of the Molecular Mechanisms of Cell Division In Escherichia coli,,82336,ZGM1,Special Emphasis Panel,,2,154000,
7761203,SC2,GM,5,,02/01/2010,01/31/2011,PAR-08-027,5SC2GM086343-02,,NIGMS:160018;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,NEW YORK,UNITED STATES,CHEMISTRY,06,620128822,US,NY,11451,YORK COLLEGE,"CHANG, EMMANUEL JOEL;",9328811;,5SC2GM086343,02/01/2009,01/31/2012,"ATP; Address; Adenosine 5'-(tetrahydrogen triphosphate); Adenosine Triphosphate; Adenylpyrophosphate; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Assay; Binding; Binding (Molecular Function); Bioassay; Biochemistry; Biologic Assays; Biologic Phenomena; Biological; Biological Assay; Biological Phenomena; CDC2 Protein Kinase; CDK; CDK1; Cancers; Cell Cycle; Cell Cycle Controller cdc2; Cell Division Control Protein 2 Homolog; Cell Division Cycle; Cell Division Cycle 2; Cell Division Cycle 2 Protein; Cell Proliferation Regulation; Cell division; Cells; Characteristics; Chemistry, Biological; Collaborations; Complex; Coupled; Cyclin-Dependent Kinase 1; Cyclin-Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclins; DISSEC; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Dependence; Development; Dissection; EC 2.7; Embryo Development; Embryogenesis; Embryonic Development; Endomycetales; Enzymes; Eukaryota; Eukaryote; Family; Funding; Future; Glycogen Synthase Kinases; Goals; Human; Human Biology; Human, General; INFLM; In Vitro; Inflammation; Investigators; Kinases; Kinetic; Kinetics; Knowledge; Label; MALD-MS; MALDI; MALDI-MS; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediating; Mentors; Metabolic; Methods; Methods and Techniques; Methods, Other; Mission; Modeling; Molecular Interaction; Mutate; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Nervous System Diseases; Neurologic Disorders; Neurological Disorders; Peptides; Phosphates; Phosphorylation; Phosphorylation Site; Phosphotransferases; Photometry/Spectrum Analysis, Mass; Pilot Projects; Population; Primary Senile Degenerative Dementia; Process; Property; Property, LOINC Axis 2; Protein Dynamics; Protein Phosphorylation; Proteins; Proteomics; Public Health; Publications; Publishing; Reaction; Reagent; Regulation; Research; Research Personnel; Researchers; S cerevisiae; Saccharomyces cerevisiae; Saccharomycetales; Scientific Publication; Site; Specificity; Spectrometry, Mass; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Mass; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Stable Isotope Labeling; System; System, LOINC Axis 4; Techniques; Technology; Temperature; Time; Transphosphorylases; United States National Institutes of Health; Variant; Variation; Work; Yeast, Baker's; Yeast, Brewer's; Yeast, Budding; Yeasts; base; casein kinase; cdc2 gene product; cdc2+ Protein; cdk Proteins; cdk1 Kinase; dementia of the Alzheimer type; dissemination research; eukaryotida; gene product; in vitro Assay; in vivo; innovate; innovation; innovative; inorganic phosphate; insight; malignancy; matrix assisted laser desorption ionization; mutant; neoplasm/cancer; nervous system disorder; neurological disease; p34 (cdc2); p34 Protein Kinase; p34CDC2; pilot study; primary degenerative dementia; protein complex; public health medicine (field); senile dementia of the Alzheimer type; skills",Using stable isotope labeling/mass spectrometry to probe Cdk1 multisite phosphory,,86343,ZGM1,Special Emphasis Panel,,2,160018,
7800326,SC2,MH,5,,02/01/2010,01/31/2011,PAR-08-027,5SC2MH087466-02,,NIGMS:145000;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,NORTHRIDGE,UNITED STATES,PSYCHOLOGY,27,055752331,US,CA,913308232,CALIFORNIA STATE UNIVERSITY NORTHRIDGE,"KANG, SUN-MEE ;",8151821;,5SC2MH087466,04/07/2009,01/31/2012,"0-11 years old; 21+ years old; Address; Adolescent; Adolescent Youth; Adopted; Adult; Age; Area; Asperger Syndrome; Asperger's Disorder; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Child; Child Youth; Children (0-21); Clinical; Clinical Assessment Tool; Clip; Cognitive; Communities; Computers; Conceptions; Data; Development; Diagnosis; Emotions; Facial Expression; Feeling; Foundations; Future; Goals; Human, Adult; Human, Child; Impairment; Individual; Individual Differences; Intelligence; Intelligence Tests; Kanner's Syndrome; Longitudinal Studies; Measures; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Paper; Pilot Projects; Process; Psyche structure; Research; Sampling; Short-Term Memory; Simulate; Social Adjustment; Social Interaction; Social Service; Social Work; Social work (field); Testing; Work; adult human (21+); base; children; college; college student; computerized; face expression; feelings; innovate; innovation; innovative; interpersonal competence; interpersonal competency; intervention program; juvenile; juvenile human; long-term study; mental; peer; pilot study; social; social adaptation; social competence; social competency; social skills; theories; tool; university student; working memory; youngster",Mutliple Social Tasks and Social Adjustment,,87466,ZGM1,Special Emphasis Panel,,2,145000,
7761222,SC3,GM,5,,02/01/2010,01/31/2011,PAR-06-493,5SC3GM082291-03,,NIGMS:111150;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN JOSE,UNITED STATES,BIOLOGY,16,056820715,US,CA,95112,SAN JOSE STATE UNIVERSITY,"OUVERNEY, CLEBER COSTA;",8768796;,5SC3GM082291,02/01/2008,01/31/2012,"21+ years old; Adult; Affect; Autoradiography; Bacteria; Buccal Cavity; Cavitas Oris; Cells; Chronic Periodontitis; Confocal Microscopy; DNA Sequence; DNA, Ribosomal; Data; Disease by Site; Disorder by Site; Environment; Environmental sludge; FISH Technic; FISH Technique; FISH analysis; Filament; Fluorescent in Situ Hybridization; Fresh Water; Freshwater; Genes; Genetics, in situ Hybridization; Goals; Habitats; Head and Neck, Buccal Cavity; Human; Human, Adult; Human, General; In Situ; In Situ Hybridization; In Situ Hybridization, Fluorescence; Individual; Investigation; Knowledge; Length; Man (Taxonomy); Man, Modern; Measures; Metabolic; Methods; Methods and Techniques; Methods, Other; Microbe; Microscopy, Confocal; Modeling; Molecular; Mouth; Nutrient; Nutritional Requirements; Oral; Oral cavity; Parodontosis; Periodontal Diseases; Periodontitis; Population; Radioautography; Relative; Relative (related person); Reproducibility; Research; Resistance; Ribosomal DNA; Role; SEQ-AN; Sampling; Sea Water; Seawater; Sequence Analyses; Sequence Analysis; Site; Sludges; Soil; Source; Students; Survey Instrument; Surveys; Techniques; Temperature; Testing; Time; Validation; adult human (21+); base; human subject; in situ Hybridization Staining Method; innovate; innovation; innovative; insight; microautoradiography; microbial community; novel; nutrient requirement; oral pathogen; oral plaque; pathogen; periodontal disorder; periodontium disease; periodontium disorder; rDNA; resistant; sample collection; social role; soil sampling; specimen collection; success; uptake",Environmental Uncultivable Bacteria Model for Understanding Human Periodontitis,,82291,ZGM1,Special Emphasis Panel,,3,111150,
7755856,SC3,GM,5,,02/01/2010,01/31/2011,PAR-06-493,5SC3GM082302-03,,NIGMS:115125;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN FRANCISCO,UNITED STATES,BIOLOGY,12,942514985,US,CA,941321722,SAN FRANCISCO STATE UNIVERSITY,"RAMIREZ, ROBERT ;",8431397;,5SC3GM082302,02/01/2008,01/31/2011,"1,2,3-Propanetriol; 1,2,3-Trihydroxypropane; 1-Alkyl-2-acetyl-sn-glycerophosphocholine; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; 2 lysophosphatidylcholine acylhydrolase; 3'5'-cyclic ester of AMP; AGEPC; Address; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Amino Acid Substitution; Arachidonic Acids; Area; Betaine; Brain; Carbamide; Catabolism; Cell Communication and Signaling; Cell Extracts; Cell Function; Cell Process; Cell Signaling; Cell Volumes; Cell membrane; Cell physiology; Cells; Cellular Expansion; Cellular Function; Cellular Growth; Cellular Physiology; Cellular Process; Chiro-Inositol; Choline Glycerophospholipids; Choline Phosphoglycerides; Coupled; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Membrane; D glucitol; Data; Deletion Mutation; Development; Diuresis; Elaqua XX; Embryo; Embryonic; Encephalon; Encephalons; Enzymes; Equilibrium; Ester Hydrolase; Eukaryota; Eukaryote; Event; Funding; Generalized Growth; Genetic Alteration; Genetic Change; Genetic defect; Glucitol; Glycerin; Glycerol; Glycine Betaine; Goals; Growth; Human; Human, General; Hydrogen Oxide; Individual; Inositol; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Kidney; Laboratories; Lead; Lecithin; Lecithinase B; Lecithinases; Left; Letters; Life; Link; Lipid Trafficking; Lipids; Lycine; Lysolecithin-Lysolecithin Acyltransferase; Lysolecithinase; Lysophospholipase; METBL; Man (Taxonomy); Man, Modern; Manuscripts; Mediating; Mesoinositol; Metabolic Processes; Metabolism; Methanaminium, 1-carboxy-N,N,N-trimethyl-, inner salt; Methylamines; Microorganisms, General; Modeling; Molecular Weight; Mutation; Nervous System, Brain; Neuropathy; Organism; Organophosphates; Osmolar Concentration; Osmolarity; Osmoregulation; Oxyneurine; PAF; PAF-Acether; PKA; Palsy; Paralysed; Pb element; Peptide Biosynthesis, Ribosomal; Pesticides; Phenotype; Phosphates; Phosphatides; Phosphatidylcholines; Phospholipase; Phospholipase B; Phospholipids; Phosphorylation; Phosphorylcholine, Acetyl Glyceryl Ether; Physiologic; Physiological; Physiology; Plasma Membrane; Platelet Activating Factor; Platelet-Activating Substance; Plegia; Population; Post-Translational Regulation; Posttranslational Regulation; Pressure; Pressure- physical agent; Process; Productivity; Property; Property, LOINC Axis 2; Protective Agents; Protective Drugs; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Kinase A; Protein Phosphorylation; Protein Synthesis, Ribosomal; Public Health; Publishing; Regulation; Renal Cell; Reporting; Research; Research Personnel; Research Training; Researchers; Role; S cerevisiae; Saccharomyces cerevisiae; San Francisco; Senior Scientist; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Sorbitol; Stress; Students; Subcellular Process; Testing; Tissue Growth; Training; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Universities; Urea; Urea Carbamide; Ureaphil; Urinary System, Kidney; Volumes, Cell; Water; Yeast, Baker's; Yeast, Brewer's; Yeasts; adenosine 3'5' monophosphate; aminomethane; balance; balance function; base; betaine compound; biological signal transduction; cAMP; cAMP-Dependent Protein Kinases; cell growth; deacylation; esterase; eukaryotida; experience; experiment; experimental research; experimental study; genome mutation; heavy metal Pb; heavy metal lead; in vivo; innovate; innovation; innovative; inorganic phosphate; insight; kidney cell; lipid transport; living system; man; man's; methanamine; methylamine; methylamine bisulfite; microorganism; monomethylamine; neuropathic; neuropathy target esterase; novel; ontogeny; paralysis; paralytic; plasmalemma; pressure; prevent; preventing; protein synthesis; public health medicine (field); renal; research study; response; social role",Physiology of Osmotic Stress in Saccharmyces cerevisiae,,82302,ZGM1,Special Emphasis Panel,,3,115125,
7755821,SC3,GM,5,,02/01/2010,01/31/2011,PAR-06-493,5SC3GM082343-03,,NIGMS:111000;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN MARCOS,UNITED STATES,BIOLOGY,50,176262681,US,CA,920784362,CALIFORNIA STATE UNIVERSITY SAN MARCOS,"MOTHE, BIANCA ROMINA;",7742296;,5SC3GM082343,02/01/2008,01/31/2012,"21+ years old; AIDS Virus; APC; ATGN; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Address; Adult; Animals; Antigen-Presenting Cells; Antigenic Determinants; Antigens; Apoptosis; Apoptosis Pathway; Appearance; Assay; Binding Determinants; Bioassay; Biologic Assays; Biological Assay; Biology; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; CD8; CD8B; CD8B1; CD8B1 gene; CSIF; CSIF-10; CTL; Cell Death, Programmed; Cell-Mediated Lympholytic Cells; Cells, CD4; Cessation of life; Chronic; Class II Antigens; Class II Major Histocompatibility Antigens; Containment; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); Cytolytic T-Cell; Cytotoxic T Cell; Cytotoxic T-Lymphocytes; Data; Death; Development; Dysfunction; ELISPOT; Educational process of instructing; Epitopes; Epitopes, T-Lymphocyte; FLR; Failure (biologic function); Functional disorder; Funding; Genetic Alteration; Genetic Change; Genetic defect; Goals; Grant; HCV; HIV; HTLV-III; Hepatitis C virus; Hepatitus C; Histocompatibility Antigens Class II; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; I-A Antigen; IL-10; IL10; IL10A; ITX; Ia Antigens; Ia-Like Antigens; Immune Response Antigens; Immune response; Immune-Response-Associated Antigens; Immunity; Immunization; Immunocompetent; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunologically Directed Therapy; Immunostimulation; Immunotherapy; Impairment; Infection; Interleukin 10 Precursor; Interleukin-10; LAV-HTLV-III; LCM Viruses; LCMV; LYT3; Lead; Lymphadenopathy-Associated Virus; Lymphocyte Mediators; Lymphocytic choriomeningitis virus; Lymphokines; MHC Class II Molecule; MHC Class II Protein; MHC class II antigen; Maintenance; Maintenances; Major Histocompatibility Complex Class II; Mammals, Mice; Mediating; Mice; Modeling; Monocytes / Macrophages / APC; Murine; Mus; Mutation; Pathogenesis; Pb element; Phase; Physiologic pulse; Physiopathology; Pilot Projects; Play; Production; Programs (PT); Programs [Publication Type]; Publications; Pulse; Research; Role; Scientific Publication; Sensitization, Immunologic; Sensitization, Immunological; Staging; Staining method; Stainings; Stains; T-Cell Epitopes; T-Cells; T-Lymphocyte; T-Lymphocyte Epitopes; T-Lymphocytes, Cytotoxic; T4 Cells; T4 Lymphocytes; Teaching; Thymus-Dependent Lymphocytes; Variant; Variation; Viral; Viral Diseases; Viremia; Virus; Virus Diseases; Virus-HIV; Viruses, General; Work; accessory cell; adult human (21+); anergy; cytokine; enzyme linked immunospot assay; exhaustion; failure; genome mutation; heavy metal Pb; heavy metal lead; helper T cell; host response; immune therapy; immunogen; immunoresponse; insight; overexpression; pathophysiology; peer; pilot study; programs; response; social role; thymus derived lymphocyte; viraemia; viral infection; viral sepsis; virus infection; virusemia",The role of CD4+ Cell Responses in LCMV Infection,,82343,ZGM1,Special Emphasis Panel,,3,111000,
7749943,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM083671-02,,NIGMS:72250;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,MIAMI,UNITED STATES,PHYSICS,21,071298814,US,FL,33199,FLORIDA INTERNATIONAL UNIVERSITY,"BONE, RICHARD A.;",7752210;,5SC3GM083671,01/01/2009,12/31/2012,"Address; Affect; Age related macular degeneration; Antioxidants; Area; Automobile Driving; Blindness; Causality; Computers; Data; Defense Mechanisms; Development; Diet; Diet Supplement; Dietary Supplements; Disease; Disorder; Drivings, Automobile; Environment; Environmental Factor; Environmental Risk Factor; Etiology; Exposure to; Eye; Eyeball; Genetic; Goals; Human; Human, General; Image; Image Analyses; Image Analysis; Incidence; Intake; Intention; Investigation; Knowledge; Light; Macular degeneration; Macular degenerative disease; Maculopathy, Age-Related; Man (Taxonomy); Man, Modern; Measurement; Measures; Mentors; Methods; Methods and Techniques; Methods, Other; Modeling; Monitor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutritional Supplement; O element; O2 element; Oxygen; Peripheral; Photoradiation; Photosensitizers; Photosensitizing Agents; Pigments; Play; Position; Positioning Attribute; Prevention; Procedures; Pupil; ROC Analysis; Research; Retina; Risk; Risk Factors; Role; Spatial Distribution; Stress; Students; System; System, LOINC Axis 4; TV; Techniques; Technology; Television; Time; United States National Institutes of Health; Visual attention; Work; Writing; Xanthophyll Carotenoids; Xanthophylls; anti-oxidant; base; cell type; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; driving; environmental risk; experience; experiment; experimental research; experimental study; falls; gaze; image evaluation; imaging; innovate; innovation; innovative; light effects; macula; macular; modifiable risk; movie; novel; oxidative damage; psychological defense mechanism; research study; senile macular disease; social role; success; sunglasses",The distribution of light on the human retina,,83671,ZGM1,Special Emphasis Panel,,2,72250,
7753190,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086245-02,,NIGMS:107625;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PRAIRIE VIEW,UNITED STATES,CHEMISTRY,10,008730355,US,TX,77446,PRAIRIE VIEW AGRI & MECH UNIVERSITY,"OKI, ADEREMI R;",1874003;,5SC3GM086245,01/01/2009,12/31/2012,"3-D; 3-Dimensional; Affect; Allografting; Apatites; Area; Autograft; Autologous Transplantation; Autotransplant; Biocompatible; Bioglass; Biomedical Research; Body Fluids; Bone; Bone Diseases; Bone Regeneration; Bone Tissue; Bone and Bones; Bones and Bone Tissue; Buckytubes; COO-; Carbon Nanotubes; Cells; Cellular biology; Ceramic; Ceramics; Chemicals; Collagen; Development; Engineering; Engineerings; Ethene Homopolymers; Ethylene Homopolymers; Ethylene Polymers; Exhibits; FLR; Failure (biologic function); Fracture; Funding; Gel; Glass; Human; Human, General; Hybrids; Hydroxyapatites; Hydroxyl; Hydroxyl Radical; Individual; Investigators; Lead; Load-Bearing; Loadbearing; Man (Taxonomy); Man, Modern; Mechanics; Methods and Techniques; Methods, Other; Mind; Minerals; Nanotubes, Carbon; Pb element; Performance; Phase; Phosphonic Acids; Phosphoric Acids; Polyesters; Polyethylenes; Polymers; Porosity; Process; Productivity; Property; Property, LOINC Axis 2; Publications; Research; Research Personnel; Researchers; Scholarship; Science; Scientific Publication; Side; Silanes; Simulate; Sodium Chloride; Sodium chloride (NaCl); Solutions; Stress; Structure; Students; Surface; Techniques; Tissue Engineering; Transplantation, Autologous; Tube; Weight-Bearing; Weight-Bearing state; Weightbearing; Work; base; bone; bone disorder; bone fracture; bone repair; bone repair material; carboapatite; carbon dioxide ion; carbonate apatite; carboxyl radical; cell biology; clinical applicability; clinical application; dahllite; engineered tissue; failure; fetal; heavy metal Pb; heavy metal lead; improved; interest; interfacial; light (weight); nano apatite; nano composite; nano tubes, Carbon; nanoapatite; nanocomposite; particle; poly(propylene fumarate); poly(propylenefumarate); repair; repaired; salt; scaffold; scaffolding; silane",Hybrid Organic-Inorganic Composite Materials for Bone Repairs,,86245,ZGM1,Special Emphasis Panel,,2,107625,
7749942,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086249-02,,NIGMS:108375;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,LOS ANGELES,UNITED STATES,NONE,32,066697590,US,CA,90032,CALIFORNIA STATE UNIVERSITY LOS ANGELES,"WEN, XIN ;",9216826;,5SC3GM086249,01/01/2009,12/31/2011,"Activities, Educational; Adsorption; Affinity; Antifreeze; Antifreeze Peptides; Antifreeze Proteins; Appointment; Assay; Award; Beetles; Binding; Binding (Molecular Function); Bioassay; Biologic Assays; Biological; Biological Assay; Biomedical Research; C element; Calorimetry; Calorimetry, Differential Scanning; Canada; Carbon; Cations; Charge; Chemicals; Circular Dichroism; Citrates; Clinical, Transplantation, Organ; Coleoptera; Commit; Computer Simulation; Computerized Models; Conflict; Conflict (Psychology); Cryoablation; Cryofixation; Cryopreservation; Cryosurgery; Data; Depressed mood; Development; Differential Scanning Calorimetry; Differential Thermal Analysis, Calorimetric; Doctor of Philosophy; Educational Activities; Educational Mainstreaming; Educational workshop; Enhancers; Exhibits; Faculty; Fish Type I APF; Fishes; Fluorescence Spectroscopy; Freezing; Frozen Foods; Funding; Future; Generalized Growth; Goals; Grafting Procedure; Grant; Growth; Hydrogen Bonding; Hydrophobic Interactions; Ice; Insecta; Insects; Interactions, Hydrophobic; Invertebrates, Insects; Investigators; Journals; Knowledge; Laboratories; Laboratory Research; Lead; Learning; Length; Letters; Ligands; Magazine; Mainstream Education, achievement; Mainstreaming; Mainstreaming (Education); Mathematical Model Simulation; Mathematical Models and Simulations; Mentors; Mentorship; Methods; Methods and Techniques; Methods, Other; Minority; Models, Computer; Molecular; Molecular Interaction; Molecular Weight; Nature; Order Coleoptera; Organ Transplantation; Organ Transplants; Organ Transplants, Including Bone Marrow for DCT; Organism; Pb element; Peer Review; Ph.D.; PhD; Plants; Plants, General; Play; Postdoc; Postdoctoral Fellow; Procedures; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protein Binding; Proteins; Public Health; Publications; Publishing; Recruitment Activity; Relative; Relative (related person); Research; Research Activity; Research Associate; Research Personnel; Research, Laboratory; Researchers; Role; Running; Salts; Scientific Publication; Scientist; Secure; Series; Simulation, Computer based; Solutions; Specificity; Spectroscopy, Fluorescence; Staging; Structure; Students; Surface; Techniques; Temperature; Testing; Thermal Hysteresis Proteins; Time; Tissue Growth; Titrations; Training; Transplantation Surgery; Type I Fish Antifreeze Proteins; Underrepresented Minority; Universities; Work; Workshop; Writing; base; biological systems; biophysical chemistry; career; cold preservation; cold storage; computational modeling; computational models; computational simulation; computer based models; computerized modeling; computerized simulation; depressed; design; designing; electron donor; experience; experiment; experimental research; experimental study; gene product; heavy metal Pb; heavy metal lead; improved; in silico; innovate; innovation; innovative; insight; interest; living system; meetings; melting; new approaches; novel; novel approaches; novel strategies; novel strategy; ontogeny; organ allograft; organ graft; organ xenograft; plasmid DNA; post-doc; post-doctoral; programs; protein expression; protein structure; public health medicine (field); recruit; research study; sadness; skills; social role; teacher; tool; under-represented minority; underserved minority; virtual simulation",Identification and Molecular Basis for Efficient Antifreeze Protein Enhancers,,86249,ZGM1,Special Emphasis Panel,,2,108375,
7753228,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086265-02,,NIGMS:98700;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,DURHAM,UNITED STATES,NONE,04,072026321,US,NC,27707,NORTH CAROLINA CENTRAL UNIVERSITY,"ZHENG, WEIFAN ;",8775524;,5SC3GM086265,01/01/2009,12/31/2012,"3-D structure; 3-dimensional structure; 3D structure; Academia; Address; Affect; Algorithms; Applications Grants; Appointment; Aran-Duchenne disease; Area; Benchmarking; Best Practice Analysis; Binding Sites; Bio-Informatics; Bioinformatics; Biological; Biotechnology; Brain; Chemical Structure; Chemicals; Chicago; Collaborations; Combining Site; Communities; Complement; Complement Proteins; Computer Simulation; Computer Vision Systems; Computerized Models; Computing Methodologies; Cruveilhier disease; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Descriptor; Development; Disease; Disorder; Drug Design; Drug Industry; Drugs; Encephalon; Encephalons; Ensure; Family; Foundations; Funding; Future; Genomics; Goals; Grant; Grant Proposals; Grants, Applications; HDAC; HDAC Proteins; Histone Deacetylase; Huntington Chorea; Huntington Disease; Huntington's; Huntington's Disease; Huntington's Disease Pathway; Huntingtons Disease; Illinois; Individual; Industry; Industry, Pharmaceutic; Informatics; Infrastructure; Internet; Investigators; Letters; Libraries; Ligands; Marketing; Mathematical Model Simulation; Mathematical Models and Simulations; Medication; Medicine; Methods; Methods and Techniques; Methods, Other; Mission; Modeling; Models, Computer; Models, Molecular; Molecular; Molecular Models; NIH; Names; National Institutes of Health; National Institutes of Health (U.S.); Nervous System, Brain; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; North Carolina; Nucleic Acid Biochemistry, Molecular Modeling; Orphan; PDE; PDE 5 enzyme; PDE4 enzyme; PDase IV; Pain; Painful; Patients; Pattern; Performance; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Industry; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Phosphodiesterases; Productivity; Progressive Chorea, Hereditary, Chronic (Huntington); Protein Binding; Protein Family; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; Protocol; Protocols documentation; Publications; QSAR; Quantitative Structure-Activity Relationship; Reactive Site; Research; Research Infrastructure; Research Personnel; Research Resources; Research Support; Research Training; Researchers; Resource Informatics; Resources; Role; Science; Science of Medicine; Scientific Publication; Scientist; Screening procedure; Shapes; Sight; Simulation, Computer based; Solid; Speed; Speed (motion); Spinal Muscular Atrophy; Staging; Structure; Structure Activity Relationship, Quantitiative; Structure-Activity Relationship; Techniques; Technology; Testing; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Universities; Validation; Vision; Vision Systems, Computer; WWW; Work; base; career; chemical informatics; chemical structure function; cheminformatics; clinical data repository; clinical data warehouse; computational methodology; computational methods; computational modeling; computational models; computational simulation; computational tools; computer based models; computer based prediction; computer infrastructure; computer methods; computer science; computer vision; computerized modeling; computerized simulation; computerized tools; computing resources; conformer; data repository; design; designing; disease/disorder; drug candidate; drug discovery; drug/agent; experiment; experimental research; experimental study; gene product; in silico; innovate; innovation; innovative; method development; model development; molecular modeling; neurodegenerative illness; novel; pharmacophore; phosphodiesterase 4; phosphodiesterase IV; phosphodiesterase V; phosphodiesterase-5; phosphoric diester hydrolase; predictive modeling; relational database; research study; screening; screenings; social role; structure function relationship; success; three dimensional structure; tool; translation research enterprise; type 4 cyclic nucleotide phosphodiesterase; virtual; virtual simulation; web; web-accessible; world wide web",Integrated Cheminformatics Resource for Orphan Neurodegenerative Diseases,,86265,ZGM1,Special Emphasis Panel,,2,98700,
7749941,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086303-02,,NIGMS:106500;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,POMONA,UNITED STATES,BIOLOGY,38,028929438,US,CA,917682557,CALIFORNIA STATE POLY U POMONA,"LIN, WEI-JEN ;",1950574;,5SC3GM086303,01/01/2009,12/31/2012,"Abscission; Allergan Brand of Botulinum A Toxin; Animals; Award; Bacteria; Bacterial Physiology; Biological; Biology; Bontoxilysin; Botox; Botulinum A Toxin; Botulinum Neurotoxin A; Botulinum Toxin Type A; Botulism; C 1 Esterase; C1 Esterase; C1 s; C1s; Cancer Center; Categories; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Cities; Clostridium; Clostridium Botulinum Toxin Type A; Clostridium botulinum; Clostridium botulinum A; Clostridium botulinum A Toxin; Clostridium botulinum type A; Collaborations; Communities; Complement 1 Esterase; Complement 1s; Complement component C1s; Complex; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Development; Discipline; Educational process of instructing; Environment; Evolution; Excision; Expert Opinion; Expression Profiling; Expression Signature; Extirpation; Faculty; Gene Cluster; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Gene Pool; Gene Transcription; Gene Transfer; Generalized Growth; Genes; Genetic Transcription; Genetics-Mutagenesis; Genome; Genomics; Genotype; Goals; Grant; Growth; Hour; Human; Human, General; Institutes; Institution; Knowledge; Laboratories; Laboratory Research; Laboratory Study; Link; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Master's Degree; Mentors; Merz Brand of Botulinum A Toxin; Methods and Techniques; Methods, Other; Microarray Analysis; Microarray-Based Analysis; Molecular Biology Techniques; Molecular Biology, Mutagenesis; Molecular Fingerprinting; Molecular Profiling; Mutagenesis; NIAID; National Institute of Allergy and Infectious Disease; Neurotoxins; Opinion, Expert; Organism; Organism-Level Process; Organismal Process; Phase; Phenotype; Physiologic Processes; Physiological Processes; Physiology; Procedures; Process; Production; Profilings, Gene Expression; Programs (PT); Programs [Publication Type]; Proteins; RNA Expression; Removal; Reproduction spores; Research; Research Activity; Research Institute; Research Resources; Research, Laboratory; Resources; Role; Salaries; Scientist; Serotyping; Slide; Spores; Students; Subcellular Process; Surgical Removal; System; System, LOINC Axis 4; Teaching; Techniques; Time; Tissue Growth; Toxic effect; Toxicities; Toxico-Infectious Botulism; Toxin; Training; Transcript Expression Analyses; Transcript Expression Analysis; Transcription; Transcription, Genetic; Underrepresented Minority; Universities; Update; Wages; Wisconsin; Work; base; biodefense; botulinum; botulinum neurotoxin; career; comparative genomics; court; deletion analysis; experience; experiment; experimental research; experimental study; functional genomics; gene product; genome sequencing; graduate student; improved; interest; living system; microarray technology; molecuar profile; molecular assembly; molecular assembly/self assembly; molecular self assembly; molecular signature; mutant; neurotoxicant; new approaches; new therapeutics; next generation therapeutics; novel approaches; novel strategies; novel strategy; novel therapeutics; ontogeny; pathogen; prevent; preventing; programs; public health relevance; research study; resection; response; social role; tool; transfer of a gene; under-represented minority; underserved minority; weapons",DNA Microarray analysis of Clostridium botulinum,,86303,ZGM1,Special Emphasis Panel,,2,106500,
7747927,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086305-02,,NIGMS:108375;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SAN ANTONIO,UNITED STATES,BIOSTATISTICS & OTHER MATH SCI,23,800189185,US,TX,782490600,UNIVERSITY OF TEXAS SAN ANTONIO,"RUAN, JIANHUA ;",9218618;,5SC3GM086305,01/01/2009,12/31/2012,"Accounting; Address; Algorithms; Animal Model; Animal Models and Related Studies; Behavior; Bio-Informatics; Bioinformatics; Biological; Biological Function; Biological Process; Biology; Bone Formation; Brain; Cancers; Cells; Characteristics; Collaborations; Comb animal structure; Combs; Communities; Community Networks; Complex; Computer Programs and Programming; Data; Development; Diabetes Mellitus; Disease; Disorder; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Drugs; Encephalon; Encephalons; Future; Gene Expression; Genes; Goals; Grant; Graph; Human; Human, General; Imagery; Infrastructure; Knowledge; Lead; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medication; Methods; Modeling; Nervous System, Brain; Noise; Osteogenesis; Pattern; Pb element; Peer Review; Pharmaceutic Preparations; Pharmaceutical Preparations; Phylogenetic Analysis; Phylogenetics; Physics; Prevention; Productivity; Property; Property, LOINC Axis 2; Publications; Research; Research Infrastructure; Research Proposals; Research Resources; Resources; Scientific Publication; Social Network; Structure; Students; System; System, LOINC Axis 4; Testing; Underrepresented Minority; Visualization; biological systems; complex biological systems; computational tools; computer program; computer programming; computer science; computerized tools; data mining; datamining; diabetes; disease classification; disease/disorder; disease/disorder classification; disorder classification; drug/agent; effective therapy; flexibility; heavy metal Pb; heavy metal lead; improved; insight; interest; malignancy; model organism; neoplasm/cancer; nosology; open source; protein protein interaction; tool; under-represented minority; underserved minority",Computational Discovery and Analysis of Community Structures in Biology Networks,,86305,ZGM1,Special Emphasis Panel,,2,108375,
7753639,SC3,GM,5,,01/01/2010,12/31/2010,PAR-08-028,5SC3GM086322-02,,NIGMS:105916;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBIA,UNITED STATES,BIOLOGY,06,073727943,US,SC,29204,BENEDICT COLLEGE,"FRAIJ, BASSAM M;",1971808;,5SC3GM086322,01/01/2009,12/31/2012,"2,2'-Dithiobisethanamine; A 23187; A23187; ANXA5; Active Sites; Affinity; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Amino Acid Sequence; Anchorin CII; Annexin A5 Protein; Annexin V; Antibiotic A23187; Apoptosis; Apoptosis Pathway; Apoptotic; Assay; Avidin; BAX; BAX Isoform Alpha; BCL2-Associated X Protein; Bax protein; Binding; Binding (Molecular Function); Bioassay; Biochemical; Biochemistry; Biologic Assays; Biological Assay; Biological Function; Biological Process; Biology; Blood Coagulation Factor IV; Blood Serum; Blotting, Western; CBP-I; Ca++ element; Calcium; Calphobindin I; Cancer Center; Cancer of Breast; Cancers; Causality; Cell Death; Cell Death Induction; Cell Death, Programmed; Cells; Chemistry; Chemistry, Biological; Coagulation Factor IV; Collaborations; Complementary DNA; Culture Media, Serum-Free; Cystamine; Cysteinamine Disulfide; Cystineamine; DNA Molecular Biology; DNA, Complementary; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Decarboxycystine; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Disease; Disorder; Educational process of instructing; Endonexin II; Environment; Enzymes; Equipment; Ethanamine, 2,2'-dithiobis-; Etiology; Factor IV; Fluorescence-Activated Cell Sorting; Fostering; Fractionation, Fluorescence Activated Cell Sorting; Gel; Gln; Glutamine; Glutaminyl-Peptide Gamma-Glutamyltransferases; Human; Human, General; In Situ; In Vitro; Induction of Apoptosis; Industry; Institution; Interdisciplinary Research; Interdisciplinary Study; Iodides; Ionophores; Isoforms; L-Glutamine; Label; Lead; Learning; Letters; Lipocortin-V; MCF-7; MCF-7 Cell; MCF7; MCF7 cell; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Measures; Membrane; Methods and Techniques; Methods, Other; Minority; Mitochondria; Mitochondrial Proteins; Modeling; Molecular; Molecular Biology; Molecular Biology, Protein Sequencing; Molecular Interaction; Molecular Weight; Multidisciplinary Collaboration; Multidisciplinary Research; Mutagenesis, Site-Directed; Mutate; N-terminal; NH2-terminal; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; PAP-I; PP4; Pb element; Peptide Fingerprinting; Peptide Mapping; Peptide Sequence Determination; Peptides; Placental Anticoagulant Protein I; Placental Protein 4; Play; Polyamine Compound; Polyamines; Preparation; Primary Senile Degenerative Dementia; Principal Investigator; Protein Isoforms; Protein Sequencing; Protein Structure, Primary; Protein-Free Media; Protein-Glutamine gamma-Glutamyltransferases; Protein-glutamine[{..}]amine gamma-glutamyltransferase; Proteins; Proteome; Q. Levoglutamide; RNA, Small Interfering; Reaction; Research; Research Resources; Resources; Role; Schools; Schools, Medical; Science; Science of Chemistry; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Serum; Serum-Free Culture Media; Serum-Free Media; Silver Staining; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Sites, Active; Small Interfering RNA; Sorting - Cell Movement; Sortings, Fluorescence-Activated Cell; South Carolina; Specificity; Staging; Staining method; Stainings; Stains; Students; Study, Interdisciplinary; System; System, LOINC Axis 4; T47D; Targeted DNA Modification; Targeted Modification; Teaching; Techniques; Testing; Thromboplastin Inhibitor; Training; Transfection; Transglutaminases; VAC-Alpha; Vascular Anticoagulant-Alpha; Western Blotting; Western Blottings; Western Immunoblotting; Work; aminoacid sequence of peptide; aminoacid sequence of protein; annexin A5; anticancer research; cDNA; cDNA Expression; cancer research; career; cartilage link protein; clinical data repository; clinical data warehouse; college; cross-link; crosslink; data repository; dementia of the Alzheimer type; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experience; expression vector; gene product; heavy metal Pb; heavy metal lead; improved; in vivo; indexing; inhibitor; inhibitor/antagonist; interest; link protein; maitotoxin; malignancy; malignant breast neoplasm; medical schools; membrane structure; mitochondrial; mitochondrial membrane; mutant; necrocytosis; neoplasm/cancer; neurodegenerative illness; peptide sequence; primary degenerative dementia; protein aminoacid sequence; protein blotting; protein sequence; relational database; science education; senile dementia of the Alzheimer type; siRNA; silver impregnation; social role; sorting",Identification of transamidated proteins involved in cell death induction,,86322,ZGM1,Special Emphasis Panel,,2,105916,
7774352,T32,CA,5,,01/01/2010,12/31/2010,PA-06-468,5T32CA009523-26,,NCI:559128;,2010,NATIONAL CANCER INSTITUTE,,LA JOLLA,UNITED STATES,CHEMISTRY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"DONOGHUE, DANIEL J;",1864364;,5T32CA009523,03/01/1993,12/31/2012,"Biochemistry; Chemistry, Biological; Generalized Growth; Growth; Oncogenesis; Regulation; Tissue Growth; ontogeny; tumorigenesis",Biochemistry of Growth Regulation and Oncogenesis,,9523,NCI,Subcommittee E - Prevention & Control,,26,559128,
7752789,T32,EY,5,,01/01/2010,12/31/2010,,5T32EY007024-30,,NEI:167848;,2010,NATIONAL EYE INSTITUTE,,HOUSTON,UNITED STATES,OPHTHALMOLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"MASSEY, STEPHEN C.;",1905741;,5T32EY007024,07/01/1975,12/31/2010,Area; Sight; Training Programs; Vision,Houston Area Vision Training Program,,7024,ZEY1,Special Emphasis Panel,,30,167848,
7805450,T32,EY,5,,12/01/2009,11/30/2010,PA-02-109,5T32EY013359-09,,NEI:105834;,2010,NATIONAL EYE INSTITUTE,,COLUMBUS,UNITED STATES,NONE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"ZADNIK, KARLA S;",1876323;,5T32EY013359,04/01/2001,11/30/2011,Optometrist; Training,Advanced Graduate Training for Optometrists,,13359,ZEY1,Special Emphasis Panel,,9,105834,
7758224,T32,HL,5,,02/01/2010,01/31/2011,PA-02-109,5T32HL007088-35,,NHLBI:358730;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,SAINT LOUIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,068552207,US,MO,631304899,WASHINGTON UNIVERSITY,"SADLER, J EVAN;",1881136;,5T32HL007088,07/01/1975,01/31/2011,Hematology; Molecular; Training,Pre-and Postgraduate Training in Molecular Hematology,,7088,ZHL1,Special Emphasis Panel,,35,358730,
7765501,T32,HL,5,,03/01/2010,02/28/2011,,5T32HL066991-08,,NHLBI:123966;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,HOUSTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,051113330,US,TX,770303498,BAYLOR COLLEGE OF MEDICINE,"CHAN, LAWRENCE ;",7358143;,5T32HL066991,04/01/2001,02/28/2013,Grant; Molecular Medicine; Training,Molecular Medicine Scholars Training Grant,,66991,NITM,NHLBI Institutional Training Mechanism Review Committee,,8,123966,
7799190,T32,HL,5,,04/01/2010,03/31/2011,,5T32HL069768-09,,NHLBI:368398;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,CHAPEL HILL,UNITED STATES,PATHOLOGY,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"MAEDA, NOBUYO ;",1865159;,5T32HL069768,04/01/2002,03/31/2012,Biology; Blood Vessels; Training Programs; pre-doc; pre-doctoral; predoc; predoctoral; vascular,Pre-doctoral Training Program in Integrative Vascular Biology,,69768,ZHL1,Special Emphasis Panel,,9,368398,
7765503,T32,HL,5,,03/01/2010,02/28/2011,PA-06-468,5T32HL086350-03,,NHLBI:284580;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DAVIS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,01,047120084,US,CA,95618,UNIVERSITY OF CALIFORNIA DAVIS,"CHIAMVIMONVAT, NIPAVAN ;",6559113;,5T32HL086350,03/01/2008,02/28/2013,"Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Organ System, Cardiovascular; Science; Training Programs; Vascular, Heart; circulatory system",Training Program in Basic and Translational Cardiovascular Science,,86350,NITM,NHLBI Institutional Training Mechanism Review Committee,,3,284580,
7799926,T32,HL,5,,04/01/2010,03/31/2011,,5T32HL091797-03,,NHLBI:179690;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,WINSTON-SALEM,UNITED STATES,PATHOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"PARKS, JOHN S;",1905561;,5T32HL091797,04/01/2008,03/31/2013,"Chronic Disease; Chronic Illness; INFLM; Inflammation; Metabolism, Lipids/Lipoproteins/Membrane Constituents; chronic disease/disorder; chronic disorder; fat metabolism; lipid metabolism","Integrative Lipid Metabolism, Inflammation, and Chronic Diseases",,91797,ZHL1,Special Emphasis Panel,,3,179690,
7755810,T35,EY,5,,12/01/2009,11/30/2010,PA-05-117,5T35EY013937-09,,NEI:36398;,2010,NATIONAL EYE INSTITUTE,,BLOOMINGTON,UNITED STATES,NONE,09,006046700,US,IN,474021847,INDIANA UNIVERSITY BLOOMINGTON,"VISWANATHAN, SURESH ;",7515308;,5T35EY013937,09/30/2001,11/30/2011,"Active Follow-up; Amblyopia; Area; Candy; Clinical; Communities; Confection; Contact Lenses; Cornea; Data; Data Collection; Development; Disease remission; Doctor of Philosophy; Dysfunction; Epidemiology; Ethical Issues; Ethics; Eye; Eye Movements; Eyeball; FLR; Faculty; Failure (biologic function); Fees; Functional disorder; Funding; Future; Ganglion Cells (Retina); Generations; Glaucoma; Graduate Education; Grant; Hand; Human; Human, General; Indiana; Individual; Industry; Infant; Institution; International; Investigators; Ion Transport; Issues, Ethical; Laboratories; Lead; Learning; Literature; Man (Taxonomy); Man, Modern; Mentors; Metabolic; Mountain Ash; Myopia; Nearsightedness; Nearsightednesses; Optics; Optometries; Optometrist; Optometry; Paper; Pb element; Ph.D.; PhD; Physiopathology; Preparation; Principal Investigator; Private Practice; Process; Program Development; Programs (PT); Programs [Publication Type]; R01 Mechanism; R01 Program; RMSN; RPG; Reading; Regulation; Remission; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Researchers; Residencies; Retinal; Retinal Ganglion Cells; Rowan; SCHED; Salaries; Schedule; Schools; Science; Scientist; Shoulder; Sight; Social Functioning; Sorbus; Source; Structure; Students; Thinking; Thinking, function; Time; TimeLine; Trabecular Meshwork; Trabecular meshwork structure; Training; Training Programs; Universities; Vision; Vision Tests; Vision research; Visit; Wages; Work; Writing; abstracting; adaptive optics; career; corneal; cost; design; designing; experience; failure; falls; follow-up; glaucomatous; graduate student; heavy metal Pb; heavy metal lead; interest; meetings; near vision; ocular surface; pathophysiology; peer; programs; retinal ganglion; role model; success; vision development; vision science; visual development; visual system development",Short-Term Research Training for Optometry Students,,13937,ZEY1,Special Emphasis Panel,,9,36398,
7765505,T35,HL,5,,03/01/2010,02/28/2011,PA-05-117,5T35HL086346-03,,NHLBI:39974;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DALLAS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"MCPHAUL, MICHAEL J;",1892280;,5T35HL086346,03/01/2008,02/28/2013,"Area; Awareness; Awarenesses; Basic Research; Basic Science; Biomedical Research; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Clinical; Clinical Research; Clinical Study; Development; Faculty; Fellowship; Funding; Institution; Institutional Award; Institutional National Research Service Award; Medical Students; Medical center; Mentors; National Heart, Lung, and Blood Institute; Organ System, Cardiovascular; Programs (PT); Programs [Publication Type]; Research; Research Activity; Students; Students, Medical; T32 Mechanism; T32 Program; Training; Training Programs; United States; Vascular, Heart; abstracting; base; circulatory system; experience; interest; pre-doc; pre-doctoral; predoc; predoctoral; programs",R.L. Kirschstein T-35 to Support NHLBI-focused Short-term Predoctoral Training,,86346,ZHL1,Special Emphasis Panel,,3,39974,
7765507,T35,HL,5,,03/01/2010,02/28/2011,PA-05-117,5T35HL090555-03,,NHLBI:82231;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NASHVILLE,UNITED STATES,PATHOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"SWIFT, LARRY L.;",1884937;,5T35HL090555,03/01/2008,02/28/2013,"Academy; Accounting; Active Follow-up; Address; Admission; Admission activity; American; Analysis, Data; Animals; Aptitude; Area; Arts; Atmosphere; Atmosphere, planetary; Attitude; Basic Research; Basic Science; Biology; Biomedical Research; Blood Vessels; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Career Choice; Chalk; Clinical; Clinical Faculty; Clinical Investigator; Clinical Nurse Educator; Clinical Research; Clinical Study; Collaborations; Collection; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Computer Assisted; Consultations; Control Groups; Criteria, Selection; Critiques; Curriculum; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Diabetes Mellitus; Editorial Comment; Editorial Comment (PT); Educational Curriculum; Educational process of instructing; Electronics; Elements; Ensure; Ethics; Evaluation; Event; Experimental Designs; Faculty; Faculty, Nursing; Fax; Fellowship; Foundations; Funding; Future; Genes; Goals; HOSP; Heart; Hospitals; Hour; Human Subject Research; Individual; Infrastructure; Institutes; Institution; Instruction; Internet; Investigation; Investigators; Jobs; Knockout Mice; Knowledge; Laboratories; Laboratory Research; Leadership; Lectures; Lectures (PT); Lectures [Publication Type]; Letters; Link; Lung; Mails; Manufactured Visual Aid; Medical; Medical Students; Medicine; Mentors; Methodology, Research; Methods; Mice, Knock-out; Mice, Knockout; NCI Scholars Program; NIH; National Institutes of Health; National Institutes of Health (U.S.); Notification; Null Mouse; Nurse Educator; Nursing Faculty; Nursing Staff Developer; Nursing Staff Development Specialist; Occupations; Oocytes; Oral; Organ System, Cardiovascular; Outcome; Outcome Study; Ovocytes; Participant; Pathway interactions; Patients; Pattern; Physicians; Plague; Play; Position; Positioning Attribute; Principal Investigator; Printing; Procedures; Process; Productivity; Professional Postions; Program Description; Programs (PT); Programs [Publication Type]; Published Comment; Publishing; Questionnaire Designs; Questionnaires; R01 Mechanism; R01 Program; RPG; Randomized; Recruitment Activity; Reporting; Research; Research Design; Research Grants; Research Infrastructure; Research Methodology; Research Methods; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Subjects; Research Technics; Research Training; Research, Laboratory; Researchers; Resources; Respiratory System, Lung; Respondent; Role; SCHED; Schedule; Scholars Program; Schools; Schools, Medical; Science; Science of Medicine; Scientist; Selection Criteria; Senior Scientist; Series; Site; Slide; Source; Specific qualifier value; Specified; Statistical Methods; Structure; Students; Students, Medical; Study Type; Study, Outcome; Suggestion; System; System, LOINC Axis 4; Teaching; Techniques, Research; Telefacsimile; Telefax; Tennessee; Time; Training; Training Programs; Transgenic Animals; Transgenic Organisms; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Disorder; Vascular, Heart; Viewpoint; Viewpoint (PT); Visit; Visual Aid; Visual Aide; WWW; Work; Yersinia pestis disease; abstracting; animal facility; base; blood vessel disorder; career; circulatory system; clinical data repository; clinical data warehouse; computer aided; data repository; design; designing; diabetes; expectation; experience; falls; flexibility; follow-up; graduate student; impression; improved; insight; interest; knockout gene; lecturer; lectures; medical schools; meetings; member; pathway; patient oriented research; patient oriented study; planetary Atmosphere; professor; programs; pulmonary; randomisation; randomization; randomly assigned; recruit; relational database; role model; satisfaction; social; social role; study design; transgenic; vascular; web; web page; willingness; world wide web","Summer Research Training Program in Heart, Lung and Vascular Biology",,90555,ZHL1,Special Emphasis Panel,,3,82231,
7780369,T36,GM,5,,02/01/2010,01/31/2011,,5T36GM008285-22,,NIGMS:1253683;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,SANTA CRUZ,UNITED STATES,,17,797779584,US,CA,950618526,SOCIETY FOR THE ADV CHICANOS/NATIVE AMER,"LINTON, MARIGOLD L.;",1995286;,5T36GM008285,12/20/1988,01/31/2013,"Address; Administrator; African American; Afro American; Afroamerican; Alaska Indian; Alaska Native; Alaskan; Alaskan American; Alaskan Indian; Alaskan Native; Behavioral; Behavioral Research; Behavioral Sciences; Black Populations; Black or African American; Caribbean; Caribbean Sea Region; Caribbean region; Chicanas; Chicanos; Communication; Communities; Data; Development; Discipline; Educational workshop; Effectiveness; Evaluation; Faculty; Focus Groups; Funding; Government Agencies; Hawaiian; Hawaiian population; Hispanic Americans; Individual; Industry; Internet; Internships; Intervention; Intervention Strategies; Interview; Investigators; Latin America; Latino; Leadership; Mentors; Methodology, Research; Mexican Americans; Mexico; NIH; National Institutes of Health; National Institutes of Health (U.S.); Native Alaskan; Native Americans; Outcome; Pacific Island Americans; Pacific Islander; Pacific Islander American; Participant; Pathway interactions; Plant Roots; Preparation; Process; Programs (PT); Programs [Publication Type]; Publications; Puerto Rico; Qualifying; Research; Research Methodology; Research Methods; Research Personnel; Research Resources; Researchers; Resources; Schools; Science; Scientific Publication; Scientist; Site; Societies; Spanish Americans; Staging; Structure; Students; Survey Instrument; Surveys; System; System, LOINC Axis 4; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Update; WWW; West Indies Region; Work; Workshop; acronyms; base; black American; career; career development; conference; design; designing; experience; interventional strategy; meetings; member; pathway; programs; role model; root; science and society; skills; success; symposium; teacher; tool; under-represented minority; underserved minority; web; world wide web",SACNAS: Initiatives for Equity in Science,,8285,MPRC,Minority Programs Review Committee,,22,1253683,
7800380,T37,MD,5,,01/04/2010,12/31/2010,MD-08-006,5T37MD001376-06,,NCMHD:241514;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,EL PASO,UNITED STATES,NONE,16,132051285,US,TX,79968,UNIVERSITY OF TEXAS EL PASO,"CURTIS, KATHLEEN ;",6730356;,5T37MD001376,07/08/2005,12/31/2013,"Advisory Committees; Advocate; Affect; Agreement; Applications Grants; Award; Biology; Budgets; Cities; Collaborations; Communities; Curriculum; Dental; Development; Discipline of Nursing; Ecuador; Education; Educational Curriculum; Educational aspects; Effectiveness; Elements; Enrollment; Ensure; Ethical Issues; Evaluation; Expenditure; Faculty; Fees; Fostering; Funding; Future; Grant; Grant Proposals; Grants, Applications; Health; Health Sciences; Hispanic Populations; Hispanics; Hispanics or Latinos; History; Institutes; Institution; Interdisciplinary Research; Interdisciplinary Study; International; Investigators; Issues, Ethical; Journals; Knowledge; Latino Population; Leadership; Length of Life; Longevity; Magazine; Medicine; Mentors; Method LOINC Axis 6; Methodology; Methods; Mexico; Minority; Minority Health and Health Disparities International Research Training; Mission; Modeling; Monitor; Multidisciplinary Collaboration; Multidisciplinary Research; Nursing; Nursing Field; Nursing Profession; On-Line Systems; Online Systems; Operation; Operative Procedures; Operative Surgical Procedures; Outcome; Peer Review; Pilot Projects; Population; Posters; Posters [Publication Type]; Principal Investigator; Professional Meetings and Conferences; Programs (PT); Programs [Publication Type]; Psychology; Public Health; R01 Mechanism; R01 Program; RPG; Recording of previous events; Recruitment Activity; Reporting; Research; Research Grants; Research Institute; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Researchers; Resource Sharing; School Health Nursing; School Nursing; Science of Medicine; Scientist; Spanish Origin; Staging; Students; Study, Interdisciplinary; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Texas; Training; Training Programs; Universities; Utilization Review; Work; abstracting; base; career; catalyst; college; community organizations; data collection methodology; data management; design; designing; enroll; experience; geographic population; graduate student; health disparities; health disparity; hispanic community; innovate; innovation; innovative; interest; knowledge base; life span; lifespan; meetings; member; minority health; online computer; pilot study; posters; programs; public health medicine (field); recruit; role model; shared decision making; success; surgery; training project; web based; working group",U. S. Mexico Interdisciplinary Research Training Program,,1376,ZMD1,Special Emphasis Panel,,6,241514,
7796843,T37,MD,5,,01/05/2010,12/31/2010,MD-08-006,5T37MD001427-17,,NCMHD:162159;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,TUCSON,UNITED STATES,VETERINARY SCIENCES,07,806345617,US,AZ,857223308,UNIVERSITY OF ARIZONA,"STERLING, CHARLES R.;",1868181;,5T37MD001427,09/01/1996,12/31/2013,"A33; Active Follow-up; Address; Animals; Area; Arizona; Arm; Awareness; Awarenesses; Behavioral Research; Biomedical Research; Budgets; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Circulatory Collapse; Collaborations; Counseling; Country; Coupled; Data; Enrollment; Environment; Ethical Issues; Ethics Committees, Research; Ethics, Research; Face; Faculty; Feedback; Feeling; Food; Friends; Funding; Future; GPA33; GPA33 gene; Health; Health Occupations; Health Professions; History; Home; Home environment; Homesickness; Hour; Human; Human, General; IRBs; Immersion; Immersion Investigative Technique; Immunization; Immunologic Stimulation; Immunological Stimulation; Immunostimulation; Individual; Institution; Institutional Review Boards; Instruction; International; Investigators; Issues, Ethical; Journals; Laboratories; Language; Learning; Letters; Link; Loneliness; Magazine; Mails; Man (Taxonomy); Man, Modern; Mentors; Metaphor; Methods and Techniques; Methods, Other; Minority; Minority Health and Health Disparities International Research Training; Modeling; Nature; Newsletter; Outcomes Research; Parents; Participant; Persons; Plague; Position; Positioning Attribute; Preparation; Problem Solving; Procedures; Program Reviews; Programs (PT); Programs [Publication Type]; Public Health; Qualifying; R01 Mechanism; R01 Program; RPG; Recommendation; Recording of previous events; Research; Research Ethics; Research Ethics Committees; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research, Outcomes; Researchers; SCHED; Schedule; Schools; Science; Scientist; Seasons; Secure; Security; Sensitization, Immunologic; Sensitization, Immunological; Shapes; Shock; Site; Students; Techniques; Thinking; Thinking, function; Time; Training; Translating; Translatings; Travel; Underrepresented Minority; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Upper arm; Visit; Work; Yersinia pestis disease; circulatory shock; college student; coping; enroll; expectation; experience; facial; falls; feelings; flexibility; follow-up; foreign language; graduate student; health disparities; health disparity; health science profession; high school; human subject protection; improved; language translation; meetings; member; minority trainee; outreach program; preference; programs; psychologic; psychological; public health medicine (field); skills; tool; under-represented minority; underserved minority; university student",Biomedical Research Abroad:  Vistas Open! /MHIRT (BRAVO!MHIRT),,1427,ZMD1,Special Emphasis Panel,,17,162159,
7800386,T37,MD,5,,01/06/2010,12/31/2010,MD-08-006,5T37MD001810-06,,NCMHD:242920;,2010,NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES,,ELIZABETH CITY,UNITED STATES,NONE,01,066024357,US,NC,27909,ELIZABETH CITY STATE UNIVERSITY,"GWEBU, EPHRAIM TOBELA;",8375543;,5T37MD001810,07/08/2005,12/31/2013,"Affect; Africa; African; African American; Afro American; Afroamerican; Bechuanaland; Behavioral Research; Bioethics; Biology; Black Populations; Black or African American; Botswana; Cancer of Prostate; Caribbean; Caribbean Sea Region; Caribbean region; Chemistry; Cities; Communities; Data; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Disease; Disorder; Educational workshop; Ethics, Biomedical; Ethnic and Racial Minorities; Goals; International; Investigators; MODY; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Maturity-Onset Diabetes Mellitus; Medical; Mentors; Minority; Minority Groups; Minority Health and Health Disparities International Research Training; Modality; Morbidity; Morbidity - disease rate; NIDDM; Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Physics; Population; Programs (PT); Programs [Publication Type]; Prostate CA; Prostate Cancer; Prostatic Cancer; Psychology; Republic of South Africa; Research; Research Personnel; Research Training; Researchers; Risk Factors; Rural; Science of Chemistry; Series; Site; Social Service; Social Work; Social work (field); Sociology; South Africa; Students; T2D; T2DM; Training; Training Programs; Travel; Type 2 diabetes; Type II diabetes; Union of South Africa; Universities; West Indies Region; Workshop; adult onset diabetes; behavioral/social science; black American; career; combat; conference; diabetes; disease/disorder; drug discovery; experience; health disparities; health disparity; ketosis resistant diabetes; maturity onset diabetes; medically disadvantaged; medically disadvantaged population; medically underserved group; medically underserved population; meetings; member; minority health; programs; psychosocial; symposium",Elizabeth City State University Minority International Research Training Program,,1810,ZMD1,Special Emphasis Panel,,6,242920,
7778378,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA013499-09,,NIAAA:342494;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,MEMPHIS,UNITED STATES,ANATOMY/CELL BIOLOGY,09,941884009,US,TN,38163,UNIVERSITY OF TENNESSEE HEALTH SCI CTR,"WILLIAMS, ROBERT W. W;",1867541;,5U01AA013499,02/05/2002,01/31/2012,"Absolute ethanol; Addictive Behavior; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Alcohols; Amazon Dolphins; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Bayesian Networks; Bed Nucleus of Stria Terminalis; Behavioral; Bio-Informatics; Bioinformatics; Boutos; Brain; Brain region; Chemical Class, Alcohol; Code; Coding System; Collaborations; Common Rat Strains; Communities; Complex; Computer Programs; Computer software; Critiques; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Development; ETOH; Encephalon; Encephalons; Ensure; Environment; Environmental Factor; Environmental Risk Factor; EtOH drinking; Ethanol; Ethanol dependence; Fore-Brain; Forebrain; Gene Expression; Gene Expression Profile; Gene variant; Generations; Genetic; Genetic Diversity; Genetic Structures; Genetic Variation; Genetic screening method; Genomics; Genotype; Goals; Grain Alcohol; Graphical interface; Human; Human, General; Hybrids; Inbred Strain; Individual Differences; Informatics; Inia; Investigators; Java; Knowledge; Lateral; Lead; Libraries; Link; Mammals, Mice; Mammals, Rats; Mammals, Rodents; Man (Taxonomy); Man, Modern; Medial; Messenger RNA; Methods; Methylcarbinol; Mice; Modeling; Models, Statistical; Molecular; Molecular Genetic; Molecular Genetics; Mouse Strains; Murine; Mus; NIAAA; National Institute on Alcohol Abuse and Alcoholism; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous System, Brain; Network Analysis; Neural Cell; Neurocyte; Neurons; Neurotransmitters; Nucleus Accumbens; Pathway Analysis; Pattern; Pb element; Physiologic; Physiological; Plant Embryos; Population; Prefrontal Cortex; Probabilistic Models; Procedures; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Protocol; Protocols documentation; Publications; Publishing; Quality Control; RNA, Messenger; Rat; Rat Strains; Rattus; Recombinants; Relapse; Reporting; Research Personnel; Research Resources; Researchers; Resolution; Resources; Rodent; Rodentia; Rodentias; Role; Scientific Publication; Seeds; Severities; Site; Software; Solid; Source Code; Statistical Methods; Statistical Models; Stress; Stria Terminalis Nucleus; Structure; Structure of terminal stria nuclei of preoptic region; Survey Instrument; Surveys; Synapses; Synaptic; System; System, LOINC Axis 4; Testing; Transcript; Validation; Variant; Variation; Variation (Genetics); Withdrawal; Work; Writing; Zygotes, Plant; addiction; alcohol ingestion; alcohol intake; alcohol product use; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic variant; amygdaloid nuclear complex; base; biological adaptation to stress; clinical data repository; clinical data warehouse; computer based statistical methods; computer program/software; data repository; environmental risk; ethanol addiction; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol use; etoh use; experiment; experimental research; experimental study; gene expression signature; genetic testing; graphic user interface; graphical user interface; heavy metal Pb; heavy metal lead; interest; mRNA; mRNA Expression; member; network models; neuronal; open source; programs; reaction; crisis; relational database; research study; response; response to alcohol; response to ethanol; seed; sex; small molecule; social role; statistical methods, computer based; stress response; stress; reaction; stressor; synapse function; synaptic function; tool; trait; transcriptome; working group",INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS,,13499,ZAA1,Special Emphasis Panel,,9,342494,
7760980,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA013510-10,,NIAAA:581084;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"GRANT, KATHLEEN A;",1899169;,5U01AA013510,02/01/2002,01/31/2012,"ACTH; ACTH (1-39); ADRGND; Absolute ethanol; Abstinence; Address; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Aeroseb-HC; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcohols; Alleles; Allelomorphs; Animals; Behavior; Candidate Disease Gene; Candidate Gene; Cetacort; Chemical Class, Alcohol; Chemotherapy-Hormones/Steroids; Chronic; Cort-Dome; Cortef; Cortenema; Corticotropin; Corticotropin (1-39); Cortisol; Cortispray; Cortril; Crab-Eating Macaque; Dermacort; ETOH; Eldecort; Endocrine; Endocrine Gland Secretion; EtOH drinking; Ethanol; Funding; Genes; Genetic Polymorphism; Grain Alcohol; Heavy Drinking; Hormones; Housing; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; Individual; Individual Differences; Length; Macaca fascicularis; Macaca mulatta; Measurable; Measures; Methylcarbinol; Monkey, Crab-Eating; Monkey, Cynomolgus; Monkeys; Nature; Nervous System, Pituitary; Nutracort; Output; Phenotype; Pituitary; Pituitary Gland; Polymorphism (Genetics); Polymorphism, Genetic; Population; Population Distributions; Predictive Value; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Procedures; Proctocort; Reaction Time; Recovery; Research; Response RT; Response Time; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk; Role; Screening procedure; Self Administration; Self-Administered; Social status; Stress; Stressful Event; Therapeutic Hormone; Therapeutic Hydrocortisone; abstaining from alcohol; abstaining from ethanol; abstinence from alcohol; abstinence from ethanol; alcohol abstinence; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; biological adaptation to stress; drink heavily; endophenotype; ethanol abstinence; ethanol abuse; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; hazardous alcohol use; heavy alcohol use; hypothalamic; polymorphism; problem drinking; psychomotor reaction time; reaction; crisis; response; response to alcohol; response to ethanol; screening; screenings; social role; stress response; stress; reaction; suprarenal gland",Stress and Ethanol Self-Administration in Monkeys,,13510,ZAA1,Special Emphasis Panel,,10,581084,
7761302,U01,AA,5,,02/01/2010,01/31/2011,,5U01AA013514-09,,NIAAA:315511;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,NASHVILLE,UNITED STATES,ANESTHESIOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"DELPIRE, ERIC J;",1861968;,5U01AA013514,01/01/2002,01/31/2012,"21+ years old; Adult; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Animal Model; Animal Models and Related Studies; Anxiety; Area; Aspiration, Respiratory; Behavior; Behavioral; Biological; Birth; Body Tissues; Breathing; Breeding; Bypass; Cancer Center; Cations; Chemical Class, Alcohol; Childhood; Chloride; Chloride Ion; Chlorides; Chronic; Cl- element; Collaborations; Communities; Complex; Cryofixation; Cryopreservation; Development; Dominance Hierarchy; ES Cell Line; ES cell; Embryo; Embryonic; Embryonic Stem Cell Line; Endocrine; Environmental Factor; Environmental Risk Factor; EtOH drinking; Exhibits; Fore-Brain; Forebrain; Funding; Gene Deletion; Gene Targeting; Generations; Genetic; Genotype; Goals; Heavy Drinking; History; Human; Human, Adult; Human, General; Inhalation; Inhaling; Inspiration, Respiratory; Investigation; Investigators; Knock-out; Knockout; Knockout Mice; Mammals, Mice; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mice; Mice, Knock-out; Mice, Knockout; Modeling; Monkeys; Murine; Mus; Nature; Neurosciences; Neurosciences Research; Null Mouse; Parturition; Pattern; Phenotype; Programs (PT); Programs [Publication Type]; Prosencephalon; Protocol; Protocols documentation; Receptors, Synaptic; Recording of previous events; Research; Research Personnel; Research Resources; Researchers; Resources; Rodent; Rodentia; Rodentias; Role; Self Administration; Social Dominance; Specificity; Stress; Synaptic Receptors; System; System, LOINC Axis 4; Targetings, Gene; Time; Tissues; Transgenic Organisms; Trauma; Universities; Withdrawal; adult human (21+); alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; cold preservation; cold storage; drink heavily; embryonic stem cell; environmental risk; ethanol abuse; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experience; exposed to alcohol; exposure to alcohol; extreme drinking; falls; functional genomics; gene deletion mutation; hazardous alcohol use; heavy alcohol use; indexing; inspiration; interest; male; model organism; neurosteroids; novel; pediatric; problem drinking; programs; social role; stem cell of embryonic origin; transgenic",Gene-Targeted Mouse Core,,13514,ZAA1,Special Emphasis Panel,,9,315511,
7761303,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA013641-10,,NIAAA:687888;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,PORTLAND,UNITED STATES,OTHER BASIC SCIENCES,01,096997515,US,OR,972393098,OREGON HEALTH AND SCIENCE UNIVERSITY,"GRANT, KATHLEEN A;",1899169;,5U01AA013641,02/10/2002,01/31/2012,"Absolute ethanol; Abstinence; Administrative Management; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Alcohols; Amazon Dolphins; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anti-Anxiety Agents; Anti-Anxiety Drugs; Anxiety; Anxiolytic Agents; Anxiolytics; Area; Bed Nucleus of Stria Terminalis; Behavioral; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Boutos; Brain; Chemical Class, Alcohol; Collaborations; Cornu Ammonis; Data; Dependence; Development; ETOH; Educational workshop; Encephalon; Encephalons; EtOH drinking; Ethanol; Future; Gene Targeting; Gene variant; Genetic; Genetic Diversity; Genetic Variation; Goals; Grain Alcohol; Grant; Heavy Drinking; Hippocampus; Hippocampus (Brain); Individual; Informatics; Inia; Intervention; Intervention Strategies; Investigators; Leadership; Link; Mammals, Mice; Mediating; Methylcarbinol; Mice; Monkeys; Murine; Mus; Nervous System, Brain; Neuromediator Receptors; Neuroregulator Receptors; Neurosciences; Neurotransmitter Receptor; Nucleus Accumbens; Office of Administrative Management; Outcome; Physiologic; Physiological; Pilot Projects; Prefrontal Cortex; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Receptors, Neurohumor; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resource Sharing; Resources; Risk; Services; Stress; Stria Terminalis Nucleus; Structure of terminal stria nuclei of preoptic region; System; System, LOINC Axis 4; TXT; Targetings, Gene; Text; Tranquilizing Agents, Minor; Variation (Genetics); Walkers; Workshop; acute stress; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol response; alcohol use; alcoholic beverage consumption; alcoholic drink intake; allelic variant; amygdaloid nuclear complex; antianxiety agent; biological adaptation to stress; conference; consomic; drink heavily; drinking; ethanol abuse; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol response; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; exposed to alcohol; exposure to alcohol; extreme drinking; hazardous alcohol use; heavy alcohol use; hippocampal; interest; interventional strategy; meetings; mutant; neural circuit; neural circuitry; neurosteroids; neurotransmitter release; novel; pilot study; problem drinking; programs; reaction; crisis; response; response to alcohol; response to ethanol; sharing data; statistics/biometry; stress response; stress; reaction; symposium; synapse function; synaptic function; synergism","INIA: Stress, Anxiety and Alcohol Abuse",,13641,ZAA1,Special Emphasis Panel,,10,687888,
7763961,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA014091-08,,NIAAA:270366;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"JONES, SARA R;",1879052;,5U01AA014091,02/01/2003,01/31/2012,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; 5-HT(1A) Receptor; 5-HT1A Receptor; Absolute ethanol; Abstinence; Acute; Address; Alcohol Drinking; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcohol, Ethyl; Alcoholic; Alcoholism; Alcohols; Amazon Dolphins; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Anabolism; Area; Autoreceptors; Behavior; Behavioral; Boozer; Boutos; Brain; Brain region; Characteristics; Chemical Class, Alcohol; Chronic; Collaborations; Consumption; D2 receptor; DBA/2 Mouse; DRD2; DRD2 Receptor; Dependent drinker; Disease; Disorder; Dopamine; Dopamine D2 Receptor; Dose; Drug abuse; ETOH; ETOH level; Encephalon; Encephalons; Environment; EtOH drinking; Ethanol; Ethanol dependence; Exposure to; Gene Deletion; Gene Expression; Genes; Goals; Grain Alcohol; Hydroxytyramine; Inbred DBA Mice; Inbred Mouse; Inbred Strains Mice; Individual; Inia; Investigators; Knock-out; Knockout; Knockout Mice; Lead; Mammals, Mice; Measures; Methylcarbinol; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knock-out; Mice, Knockout; Mice, Mutant Strains; Microdialysis; Molecular; Mouse Strains; Mouse, DBA; Murine; Mus; Mutant Strains Mice; Mutate; Nervous System, Brain; Neurobiology; Nucleus Accumbens; Null Mouse; Pattern; Pb element; Phenotype; Play; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Receptor, 5-Hydroxytryptamine 1A; Receptor, Serotonin, 5-HT1A; Recombinants; Recovery; Relapse; Relative; Relative (related person); Research; Research Personnel; Researchers; Role; Serotonin 1A Receptor; Services; Slice; Stress; Testing; Ventral Tegmental Area; Withdrawal; abuse of drugs; abuses drugs; addiction; alcohol addiction; alcohol avoiding mice; alcohol dependency; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol level; alcohol measurement; alcohol product use; alcohol response; alcohol reward; alcohol use; alcohol withdrawal; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; amygdaloid nuclear complex; base; biosynthesis; disease/disorder; dopamine system; drinking; drinking behavior; environmental stressor; ethanol addiction; ethanol avoiding mice; ethanol consumption; ethanol dependency; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol measurement; ethanol product use; ethanol response; ethanol reward; ethanol use; ethanol withdrawal; ethanol-dependent; ethyl alcohol measurements; etoh use; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; extracellular; gene deletion mutation; heavy metal Pb; heavy metal lead; in vivo; interest; mRNA Expression; mouse model; mouse mutant; neurobiological; preference; problem drinker; programs; public health medicine (field); receptor function; research study; response; response to alcohol; response to ethanol; social role; uptake; vapor; ventral tegmentum; withdrawal from alcohol","Ethanol, Stress and Dopamine",,14091,ZAA1,Special Emphasis Panel,,8,270366,
7764622,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA014095-08,,NIAAA:419448;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,CHARLESTON,UNITED STATES,PSYCHIATRY,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BECKER, HOWARD C.;",1959504;,5U01AA014095,03/01/2003,01/31/2012,"3 alpha-Hydroxy-5 alpha-pregnan-20-one; Absolute ethanol; Abstinence; Acute; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Alcohols; Allopregnanolone; Amazon Dolphins; Animals; Behavior; Biological; Blood Plasma; Boutos; Brain; Chemical Class, Alcohol; Chronic; Communities; Complement; Complement Proteins; Complex; Consumption; Corticosterone; Dependence; Development; ETOH; Encephalon; Encephalons; Environmental Factor; Environmental Risk Factor; EtOH drinking; Ethanol; Ethanol dependence; Event; Funding; Goals; Grain Alcohol; History; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Inia; Investigators; Lead; Link; Literature; Mammals, Mice; Measures; Mediating; Methylcarbinol; Mice; Modeling; Murine; Mus; Nervous System, Brain; Nervous System, Pituitary; Neuroendocrine; Neuroendocrine System; Neuropeptides; Neurosecretory Systems; Pathway interactions; Pb element; Peripheral; Pituitary; Pituitary Gland; Plasma; Play; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Pregnanolone, (3alpha,5alpha)-isomer; Process; Programs (PT); Programs [Publication Type]; Recording of previous events; Relapse; Research; Research Personnel; Research Proposals; Researchers; Reticuloendothelial System, Serum, Plasma; Rewards; Role; Self Administration; Serum, Plasma; Stress; System; System, LOINC Axis 4; Withdrawal; Work; acute stress; addiction; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol relapse; alcohol research; alcohol seeking; alcohol seeking behavior; alcohol use; alcoholic beverage consumption; alcoholic drink intake; drinking; drinking behavior; environmental risk; environmental stressor; ethanol abuse; ethanol addiction; ethanol consumption; ethanol drinking; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol relapse; ethanol research; ethanol seeking; ethanol use; ethanol-seeking behavior; etoh use; experience; exposed to alcohol; exposure to alcohol; hazardous alcohol use; heavy metal Pb; heavy metal lead; hypothalamic; mouse model; neurosteroids; novel; pathway; problem drinking; programs; social role",Ethanol Dependence and Stress Effects on Ethanol Drinking: CRF & Neurosteroids,,14095,ZAA1,Special Emphasis Panel,,8,419448,
7764621,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA014106-08,,NIAAA:340718;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,WINSTON-SALEM,UNITED STATES,PHYSIOLOGY,05,937727907,US,NC,27157,WAKE FOREST UNIVERSITY HEALTH SCIENCES,"FRIEDMAN, DAVID P;",1910020;,5U01AA014106,02/01/2003,01/31/2012,"21+ years old; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; 5-HT(1A) Receptor; 5-HT-2A Gene; 5-HT1A Receptor; 5-HT2A; 5-Hydroxytryptamine; 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene; 5-Hydroxytryptamine Receptor 2A Gene; 5HT; 5HT transporter; 5HTT protein; Absolute ethanol; Address; Adenohypophysis; Adult; Alcohol Drinking; Alcohol abuse; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Alcohols; Ammon Horn; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animals; Anterior Lobe of Pituitary; Anterior Lobe of the Pituitary Gland; Anterior Pituitary Gland; Anterior pituitary; Area; Autoradiography; Banking, Tissue; Behavioral; Birth; Body Tissues; Brain; Brain Part; Brain region; CRF receptor type 2; CRF-R2; CRF2 receptor; Cataloging; Catalogs; Chemical Class, Alcohol; Childhood; Chronic stress; Cognitive; Complex; Cornu Ammonis; Corticotropin Releasing-Factor Receptors; Corticotropin-Releasing Hormone Receptors; DRN; Development; Dorsal; Dose; Drugs; ETOH; Effects, Longterm; Encephalon; Encephalons; Enteramine; Environment; EtOH drinking; Ethanol; Event; Exposure to; Fore-Brain; Forebrain; Funding; Future; Grain Alcohol; HTR2; HTR2 Gene; HTR2A; HTR2A gene; Heavy Drinking; Hippocampus; Hippocampus (Brain); Hippophaine; Human, Adult; Hypothalamic structure; Hypothalamus; In Vitro; In element; Indium; Infant; Investigators; Lead; Life; Link; Long-Term Effects; Macaca mulatta; Mammals, Primates; Measures; Medial; Mediating; Medication; Methylcarbinol; Modeling; Monkeys; Mothers; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System, Brain; Neural Cell; Neurobiology; Neurocyte; Neuroendocrine; Neuroendocrine System; Neuronal Transmission; Neurons; Neurosecretory Systems; Nurseries; Parents; Pars Anterior Pituitary Gland; Parturition; Pathway interactions; Pattern; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiologic; Physiological; Pituitary Gland, Anterior; Play; Prefrontal Cortex; Primates; Process; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Prosencephalon; Public Health; Radioautography; Receptor Protein; Receptor, 5-Hydroxytryptamine 1A; Receptor, Serotonin, 5-HT1A; Receptors, CRF; Receptors, CRH; Receptors, Corticotropin-Releasing Hormone; Research; Research Design; Research Personnel; Research Resources; Researchers; Residual; Residual state; Resources; Rest; Rewards; Rhesus; Rhesus Macaque; Rhesus Monkey; Risk; Role; Self Administration; Self-Administered; Series; Serotonin; Serotonin 1A Receptor; Serotonin 5-HT-2 Receptor Gene; Societies; Stress; Structure; Study Type; Study models; Substance abuse problem; System; System, LOINC Axis 4; Testing; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Tissues; abuse of substances; abused drugs; adult human (21+); adult youth; alcohol effect; alcohol exposed; alcohol exposure; alcohol ingestion; alcohol intake; alcohol problem; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; amygdaloid nuclear complex; base; biological adaptation to stress; corticotropin-releasing-factor receptor 2; density; design; designing; dorsal raphe nucleus; drink heavily; drinking; drinking behavior; drug of abuse; drug/agent; drugs abused; drugs of abuse; early childhood; ethanol abuse; ethanol consumption; ethanol drinking; ethanol effect; ethanol exposed; ethanol exposure; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; experience; experiment; experimental research; experimental study; exposed to alcohol; exposure to alcohol; extreme drinking; hazardous alcohol use; heavy alcohol use; heavy metal Pb; heavy metal lead; hippocampal; hypothalamic; maternal separation; neural circuit; neural circuitry; neurobiological; neuronal; neurosteroids; neurotransmission; pathway; pediatric; problem drinking; programs; public health medicine (field); raphe nuclei; reaction; crisis; receptor; research study; response; reward circuitry; serotonin transporter; social role; sodium-dependent serotonin transporter; stress response; stress; reaction; study design; substance abuse; traumatized children; young adult",Early Stress & Alcoholism: Neurobiological Analysis,,14106,ZAA1,Special Emphasis Panel,,8,340718,
7764810,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA016662-04,,NIAAA:383888;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"MILES, MICHAEL F.;",1893128;,5U01AA016662,02/20/2007,01/31/2012,"Alcohols; Algorithms; Amazon Dolphins; Analysis, Data; Archives; Bio-Informatics; Bioinformatics; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Boutos; Chemical Class, Alcohol; Clinical Trial Overviews; Collaborations; Communication; Communities; Complex; Computer Simulation; Computerized Models; Data; Data Analyses; Data Analysis, Statistical; Data Banks; Data Base Management; Data Bases; Data Interpretation, Statistical; Data Pooling; Data Poolings; Data Set; Data Storage and Retrieval; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Development; Discipline; Documentation; Evolution; Experimental Designs; Generations; Genes; Goals; IT Systems; Individual; Informatics; Information Systems; Information Technology Systems; Infrastructure; Inia; Institution; Investigators; Laboratories; Mathematical Model Simulation; Mathematical Models and Simulations; Meta-Analyses; Meta-Analysis; Methods; Mice, Mutant Strains; Models, Computer; Mutant Strains Mice; On-Line Systems; Online Systems; Pathway interactions; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Infrastructure; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Support; Researchers; Resources; Role; Sampling; Secure; Services; Simulation, Computer based; Site; Statistical Data Analyses; Statistical Data Interpretation; Stress; Systems, Data; Tennessee; Testing; Universities; Virginia; alcohol research; base; clinical data repository; clinical data warehouse; computational modeling; computational models; computational simulation; computational tools; computer based models; computerized modeling; computerized simulation; computerized tools; data integration; data repository; data retrieval; data storage; design; designing; ethanol research; experiment; experimental research; experimental study; improved; in silico; member; mouse mutant; novel; online computer; pathway; programs; relational database; research study; social role; statistics/biometry; tool; tool development; virtual simulation; web based; web site; web-accessible",INIA-STRESS: Informatics and Analysis Core,,16662,ZAA1,Special Emphasis Panel,,4,383888,
7761305,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA016666-04,,NIAAA:242752;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,VANCOUVER,CANADA,,,251949962,CA,BC,V6T 1Z3,UNIVERSITY OF BRITISH COLUMBIA,"GOLDOWITZ, DANIEL ;",1871718;,5U01AA016666,03/01/2007,01/31/2012,"Acute; Alcohol Drinking; Alcohol consumption; Alcohols; Amazon Dolphins; Anxiety; Behavior; Behavioral; Boutos; Chemical Class, Alcohol; Chronic; Communities; Complement; Complement Proteins; Convulsions; Corticosterone; Cryofixation; Cryopreservation; Data; Data Banks; Data Base Management; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Elements; Embryo; Embryonic; Equipment and supply inventories; EtOH drinking; Exhibits; Generations; Genetic; Genetics-Mutagenesis; Genotype; High Throughput Assay; Individual; Informatics; Information Dissemination; Inia; Inventory; Investigators; Knock-out; Knockout; Knowledge; Maintenance; Maintenances; Mammals, Mice; Measures; Mice; Mice, Mutant Strains; Microsatellite Markers; Microsatellite Repeats; Microsatellites; Modeling; Molecular; Molecular Biology, Mutagenesis; Murine; Mus; Mutagenesis; Mutant Strains Mice; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Operation; Operative Procedures; Operative Surgical Procedures; Phenotype; Polymorphism, Single Base; Population; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Production; Programs (PT); Programs [Publication Type]; Quality Control; Recombinants; Research Personnel; Research Resources; Researchers; Resources; SNP; SNPs; Screening procedure; Self Administration; Services; Single Nucleotide Polymorphism; Stress; Surgical; Surgical Interventions; Surgical Procedure; Testing; Withdrawal; alcohol ingestion; alcohol intake; alcohol product use; alcohol research; alcohol use; alcoholic beverage consumption; alcoholic drink intake; clinical data repository; clinical data warehouse; cold preservation; cold storage; consomic; data repository; dependence relapse; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol research; ethanol use; etoh use; experience; high throughput screening; mouse model; mouse mutant; mutant; novel; programs; relational database; screening; screenings; surgery",INIA: Mouse Resources Core,,16666,ZAA1,Special Emphasis Panel,,4,242752,
7764809,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA016667-04,,NIAAA:241782;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,RICHMOND,UNITED STATES,PHARMACOLOGY,03,105300446,US,VA,232980568,VIRGINIA COMMONWEALTH UNIVERSITY,"MILES, MICHAEL F.;",1893128;,5U01AA016667,02/10/2007,01/31/2012,"1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide; 3 alpha-Hydroxy-5 alpha-pregnan-20-one; ACTH-Releasing Factor; Absolute ethanol; Affect; Alcohol Drinking; Alcohol consumption; Alcohol, Ethyl; Alcoholism; Allopregnanolone; Amazon Dolphins; Animal Housing; Animals; Anxiety; Behavioral; Behavioral Assay; Behavioral Model; Bio-Informatics; Bioinformatics; Blood Plasma; Blotting, Western; Boutos; Brain; Brain region; C57BL/6 Mouse; CRF-41; CRH; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chronic; Collaborations; Corticoliberin; Corticosterone; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; ES Cell Line; ES cell; ETOH; Embryonic Stem Cell Line; Encephalon; Encephalons; Environmental Factor; Environmental Risk Factor; EtOH drinking; Ethanol; Exposure to; Expression Profiling; Expression Signature; Gene Expression; Gene Targeting; Genes; Genes, A; Genes, Q; Genes, vif; Genetic; Genome; Genomics; Goals; Grain Alcohol; Grant; Heavy Drinking; Hierarchy, Social; House mice; Housing; Housing, Animal; Human; Human, General; Inbred Mouse; Individual; Individual Differences; Inia; Intake; Intracellular Communication and Signaling; Investigators; Knock-out; Knockout; Knockout Mice; Laboratories; Liquid substance; Mammals, Mice; Mammals, Primates; Man (Taxonomy); Man, Modern; Measures; Methylcarbinol; Mice; Mice, Knock-out; Mice, Knockout; Microinjections; Molecular; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Mus musculus; Nervous System, Brain; Neurochemistry; Null Mouse; Pattern; Pharmacology; Phase; Plasma; Population; Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-; Pregnanolone, (3alpha,5alpha)-isomer; Primates; Procedures; Programs (PT); Programs [Publication Type]; Recombinant Inbred Strain; Recombinants; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Serum, Plasma; Risk; Role; SUBGP; Saccharin; Sampling; Scheme; Science of neurochemistry; Serum, Plasma; Siblings; Signal Transduction; Signal Transduction Systems; Signaling; Social Hierarchy; Social Interaction; Stress; Subgroup; Targetings, Gene; Testing; Variant; Variation; Viral Vector; Western Blotting; Western Blottings; Western Immunoblotting; abstaining from alcohol; abstaining from ethanol; abstinence from alcohol; abstinence from ethanol; alcohol abstinence; alcohol ingestion; alcohol intake; alcohol product use; alcohol use; alcoholic beverage consumption; alcoholic drink intake; base; biological signal transduction; clinical data repository; clinical data warehouse; corticotropin releasing hormone; data repository; drink heavily; drinking; drinking behavior; embryonic stem cell; environment effect on gene; environmental risk; environmental stressor; ethanol abstinence; ethanol consumption; ethanol drinking; ethanol ingestion; ethanol intake; ethanol product use; ethanol use; etoh use; excess alcohol consumption; excess alcohol ingestion; excess ethanol ingestion; excessive alcohol consumption; excessive alcohol ingestion; excessive alcohol intake; excessive drinking; excessive ethanol ingestion; extreme drinking; fluid; gene environment interaction; heavy alcohol use; immunocytochemistry; liquid; molecuar profile; molecular signature; neurochemistry; neurosteroids; novel; programs; protein blotting; relational database; response; social; social role; social stress; sor Genes; stem cell of embryonic origin; stressor; vif Genes",Genomics analysis of social stress and individual variation in ethanol drinking,,16667,ZAA1,Special Emphasis Panel,,4,241782,
7764808,U01,AA,5,,02/01/2010,01/31/2011,AA-06-101,5U01AA016668-04,,NIAAA:343748;,2010,NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM,,DALLAS,UNITED STATES,PSYCHIATRY,30,800771545,US,TX,753909105,UNIVERSITY OF TEXAS SW MED CTR/DALLAS,"ADINOFF, BRYON H;",1890153;,5U01AA016668,05/20/2007,01/31/2012,"(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1-24-Corticotropin; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione; 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone; 16Alpha-methyl-9alpha-fluoroprednisolone; 21+ years old; 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha- methylprednisolone; ACTH; ACTH (1-39); ACTH 1-24; ACTH-Releasing Factor; ADRGND; Aacidexam; Abstinence; Address; Adexone; Adrenal Cortex; Adrenal Glands; Adrenals; Adrenocorticotropic Hormone; Adrenocorticotropin; Adult; Aeroseb-HC; Aknichthol Dexa; Alba-Dex; Alcohol Drinking; Alcohol Intoxication; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic Intoxication; Alcoholism; Alcohols; Alin; Alin Depot; Alin Oftalmico; Amazon Dolphins; Ambene; Amplidermis; Anemul mono; Antimicotico; Aquapred; Auxiloson; Azona; Baycuten; Baycuten N; Behavioral; Biological; Boutos; Brain; CRF-41; CRH; Central Nervous System; Cetacort; Chemical Class, Alcohol; Childhood; Chronic stress; Clinical; Cognition; Corson; Cort-Dome; Cortef; Cortenema; Cortex of adrenal gland; Corticoliberin; Corticotropin; Corticotropin (1-24)-Peptide; Corticotropin (1-24)-Tetracosapeptide; Corticotropin (1-39); Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone-41; Cortidexason; Cortisol; Cortispray; Cortisumman; Cortril; Cosyntropin; Decacort; Decadrol; Decadron; Decalix; Decameth; Decasone R.p.; Dectancyl; Deenar; Dekacort; Deltafluorene; Dermacort; Deronil; Desamethasone; Desameton; Development; Dex-4; Dexa-Mamallet; Dexa-Rhinosan; Dexa-Scheroson; Dexa-sine; Dexace; Dexacortal; Dexacortin; Dexafarma; Dexafluorene; Dexalocal; Dexamecortin; Dexameth; Dexamethasone; Dexamethasonum; Dexamonozon; Dexapos; Dexinoral; Dexone; Dinormon; Drunkenness; Drunkennesses; Dysfunction; Eldecort; Emotions; Encephalon; Encephalons; Equilibrium; EtOH drinking; EtOH intoxication; Ethanol dependence; Feedback; Fluoro-9alpha Methyl-16alpha Prednisolone; Fluorodelta; Fortecortin; Functional disorder; Gammacorten; Glucocorticoids; HPA; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare worker; Heart; Hexadecadrol; Hexadrol; Human; Human, Adult; Human, General; Hydrocortisone; Hydrocortone; Hypophysis; Hypophysis Cerebri; Hypothalamic structure; Hypothalamus; Hytone; Immune Function, Cellular; Individual; Inia; Intervention; Intervention Strategies; Investigators; Laboratories; Link; Lokalison-F; Loverine; Man (Taxonomy); Man, Modern; Measures; Mediating; Methods; Methylfluorprednisolone; Millicorten; Mymethasone; Nervous System, Brain; Nervous System, CNS; Nervous System, Pituitary; Neuraxis; Neuroendocrine; Neuroendocrine System; Neurosecretory Systems; Nutracort; Ocasa; Orgadrone; Organism; Patients; Physiologic; Physiological; Physiopathology; Pituitary; Pituitary Gland; Pituitary-Adrenal System; Play; Population; Predni-F; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-; Probability; Process; Proctocort; Programs (PT); Programs [Publication Type]; Public Speaking; Recovery; Regulation; Relapse; Relative; Relative (related person); Research Personnel; Researchers; Rewards; Risk; Risk Factors; Role; Speaking, Public; Spersadex; Spersadox; Stress; Substance Use Disorder; Synthetic ACTH; System; System, LOINC Axis 4; Tetracosactide; Tetracosactrin; Tetracosapeptide; Therapeutic Glucocorticoid; Therapeutic Hydrocortisone; Trauma; Trier Social Stress Test; Visumetazone; Vulnerable Populations; Work; adult human (21+); alcohol addiction; alcohol dependency; alcohol ingestion; alcohol intake; alcohol product use; alcohol relapse; alcohol use; alcohol withdrawal; alcohol-dependent; alcoholic beverage consumption; alcoholic drink intake; alpha-1,24-Corticotropin; alpha1-24-Corticotropin; auricularum; balance; balance function; biological adaptation to stress; chronic EtOH drinking; chronic alcohol consumption; chronic alcohol drinking; chronic alcohol ingestion; chronic alcohol use; chronic ethanol consumption; chronic ethanol drinking; chronic ethanol ingestion; corticotropin releasing hormone; drinking; drinking behavior; environmental stressor; ethanol addiction; ethanol consumption; ethanol dependency; ethanol drinking; ethanol ingestion; ethanol intake; ethanol intoxication; ethanol product use; ethanol relapse; ethanol use; ethanol withdrawal; ethanol-dependent; etoh use; health care personnel; health care worker; health provider; healthcare personnel; hypothalamic; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-adrenal axis; hypothalmus-pituitary-adrenal axis; immune function; interventional strategy; living system; medical personnel; meetings; neurosteroids; pathophysiology; pediatric; pituitary adrenal axis; prevent; preventing; programs; prospective; psychologic; psychological; reaction; crisis; response; social role; stress response; stress; reaction; stressor; suprarenal gland; treatment provider; withdrawal from alcohol","Stress, HPA Axis Dysfunction, and Relapse in Alcoholism",,16668,ZAA1,Special Emphasis Panel,,4,343748,
7753906,U01,AI,5,,01/01/2010,12/31/2010,AI-07-004,5U01AI031834-18,,NCI:166666;NIAID:2820680;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BROOKLYN,UNITED STATES,OBSTETRICS & GYNECOLOGY,11,040796328,US,NY,11203,SUNY DOWNSTATE MEDICAL CENTER,"MINKOFF, HOWARD ;",1885499;,5U01AI031834,03/01/1992,12/31/2012,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Analysis, Data; Area; Behavior; Behavioral; Behavioral Sciences; Blood Specimen Collection; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Clinical; Collaborations; Collection; Color; Colposcopy; Compliance, Protocol; Country; Data; Data Analyses; Drug Kinetics; Enrollment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Fasting; Goals; HIV; HIV Infections; HPV; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hair; Human Immunodeficiency Viruses; Human Papillomavirus; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Infection; Infectious Human Wart Virus; Infrastructure; Investigators; Knowledge; LAV-HTLV-III; Language; Left Ventricular Dysfunction; Logistics; Lymphadenopathy-Associated Virus; Manuscripts; Measurement; Measures; Minority; National NeuroAids Tissue Consortium; Neurocognition; Neuropathy; Organ System, Cardiovascular; Papilloma Virus, Human; Papillomavirus, Human; Participant; Pharmacokinetics; Population; Position; Positioning Attribute; Programs (PT); Programs [Publication Type]; Protocol; Protocol Compliance; Protocols documentation; Publications; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Research Resources; Research Specimen; Researchers; Residual; Residual state; Resources; Science; Scientific Advances and Accomplishments; Scientific Publication; Site; Specimen; Substance abuse problem; T-Lymphotropic Virus Type III Infections, Human; Vascular, Heart; Ventricular Dysfunction, Left; Virus-HIV; Visit; Woman; Writing; abuse of substances; cancer specimen resource; circulatory system; cohort; effective therapy; enroll; fasted; fasts; improved; insight; interest; neuropathic; programs; psychosocial; recruit; sample collection; scientific accomplishments; scientific advances; specimen collection; substance abuse; success; wart virus; working group",Brooklyn Women's Interagency HIV Study (WIHS) IV,,31834,ZAI1,Special Emphasis Panel,,18,2987346,
7753214,U01,AI,5,,01/01/2010,12/31/2010,AI-07-004,5U01AI034989-17,,NCI:166666;NIAID:2866686;NIDA:146723;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SAN FRANCISCO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,12,094878337,US,CA,941430962,UNIVERSITY OF CALIFORNIA SAN FRANCISCO,"GREENBLATT, RUTH MARTHA;",1885498;,5U01AI034989,12/01/1997,12/31/2012,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Age; Analysis, Data; California; Cancers; Change of Life, Female; Clinic; Clinical; Collaborations; Communities; Complex; Data; Data Analyses; Data Collection; Endocrinology; Funding; Genetic; Goals; HIV; HTLV-III; Hepatology; High Risk Woman; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Institution; Instruction; Investigator-Initiated Research; Investigators; LAV-HTLV-III; Leadership; Link; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Menopause; Metabolism and Endocrinology; Methodology, Research; Methods; Participant; Pathogenesis; Pharmacology; Procedures; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Reporting; Research; Research Grants; Research Methodology; Research Methods; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Risk; San Francisco; Science; Science of Statistics; Scientist; Site; Source; Specimen Handling; Specimen Handlings; Specimen Processing; Statistics; Structure; Training; United States; Universities; Virus-HIV; Woman; biopsy of liver; career; career development; cohort; liver biopsy; malignancy; member; menopausal; neoplasm/cancer; statistics; women at high risk",The Connie Wofsy Women's HIV Study,,34989,ZAI1,Special Emphasis Panel,,17,3180075,
7753863,U01,AI,5,,01/01/2010,12/31/2010,AI-07-004,5U01AI034993-17,,NCI:166666;NIAAA:99000;NIAID:2780553;NIDA:103029;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,,07,068625136,US,IL,60612,HEKTOEN INSTITUTE FOR MEDICAL RESEARCH,"COHEN, MARDGE H;",6766041;,5U01AI034993,01/01/1994,12/31/2012,"21+ years old; AIDS; AIDS Virus; AIDS clinical trial group; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Adult; Aging; Analysis, Data; Area; B Virus; Behavioral; Brain; Cancers; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cercopithecid herpesvirus 1; Cercopithecine Herpesvirus 1; Cessation of life; Change of Life, Female; Chicago; Clinical; Clinics and Hospitals; Clinics or Hospitals; Cohort Studies; Collaborations; Concurrent Studies; Consequences of HIV; County; County Hospitals; Data Analyses; Data Quality; Death; Disease; Disease Progression; Disorder; Encephalon; Encephalons; Enrollment; Ensure; Epidemiology; Fostering; Genetic; Genital; Genital system; Grant; HBV; HCV; HCV infection; HIV; HIV Infections; HIV therapy; HOSP; HPV; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Services; Hepatic Disorder; Hepatitis B Virus; Hepatitis C; Hepatitis C virus; Hepatitis C virus infection; Hepatitis Virus, Homologous Serum; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Hepatitus C; Herpes Virus B; Herpes simiae; Herpesvirus 1 (alpha), Cercopithecine; Herpesvirus 1, Cercopithecine; Herpesvirus B; Herpesvirus simiae; History; Hormonal; Hospitals; Hospitals, County; Hospitals, University; Housing; Human Immunodeficiency Viruses; Human Papillomavirus; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Illinois; Immunologic Deficiency Syndrome, Acquired; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Impairment; Infection; Infectious Human Wart Virus; Institutes; Investigators; LAV-HTLV-III; Laboratories; Laboratory Markers; Leadership; Liver diseases; Lymphadenopathy-Associated Virus; Malignant Neoplasms; Malignant Tumor; Medical Research; Medical center; Menopause; Metabolic; Minority; Monkey B Virus; Morbidity; Morbidity - disease rate; NANBH; Nervous System, Brain; Neurocognitive; Organ System, Cardiovascular; PT-NANBH; Papilloma Virus, Human; Papillomavirus, Human; Parenterally-Transmitted Non-A, Non-B Hepatitis; Participant; Pathogenesis; Physical Function; Presbyterian Church; Presbyterians; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Psychosocial Factor; Publications; Quality, Data; R01 Mechanism; R01 Program; RPG; Recording of previous events; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Specimen; Research, Medical; Researchers; Retrovirology; Risk; Science; Science of Virology; Scientific Publication; Senescence; Services; Shipping; Ships; Simian Herpesvirus; Site; Specimen; Specimen Handling; Specimen Handlings; Specimen Processing; Structure; T-Lymphotropic Virus Type III Infections, Human; Toxic effect; Toxicities; United States; University Hospitals; Vascular, Heart; Virology; Virus-HIV; Wit; Woman; adult human (21+); age effect; aging effect; antiretroviral therapy; cardiovascular disorder; circulatory system; clinical research site; clinical site; cohort; cooking; data management; disease/disorder; enroll; follow-up; health care service; hepatitis non A non B; hepatitis nonA nonB; hepatopathy; interest; liver disorder; malignancy; menopausal; metropolitan; neoplasm/cancer; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; performance site; programs; prospective; psychosocial variables; response; senescent; treatment effect; urogenital system (genital part); viral resistance; virology; wart virus; working group","Women's Interagency HIV Study (WIHS) IV, Chicago Consortium",,34993,ZAI1,Special Emphasis Panel,,17,3149248,
7754091,U01,AI,5,,01/01/2010,12/31/2010,AI-07-004,5U01AI035004-17,,NCI:166666;NIAID:3007878;NIDA:245248;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,,17,041581026,US,NY,104672490,"MONTEFIORE MEDICAL CENTER (BRONX, NY)","ANASTOS, KATHRYN M;",1864062;,5U01AI035004,08/01/1993,12/31/2012,"AIDS Virus; AOD use; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Alcohol or Other Drugs use; Analysis, Data; Antiretroviral Therapy, Highly Active; Area; Collaborations; Collection; Communities; Data; Data Analyses; Data Quality; Development; Disease Progression; Ensure; Epidemic; HAART; HCV infection; HIV; HTLV-III; Hepatitis C; Hepatitis C virus infection; Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted; Highly Active Antiretroviral Therapy; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; International; Investigation; Investigators; LAV-HTLV-III; Leadership; Lymphadenopathy-Associated Virus; Manuscripts; Metabolic; Monitor; NANBH; NIH; National Institutes of Health; National Institutes of Health (U.S.); Organization Charts; PT-NANBH; Paper; Parenterally-Transmitted Non-A, Non-B Hepatitis; Pathogenesis; Productivity; Quality, Data; Recording of previous events; Research; Research Personnel; Research Specimen; Researchers; Ruanda; Rwanda; SIS; Sight; Sister; Site; Specimen; Therapeutic; United States National Institutes of Health; Virus-HIV; Vision; Visit; Woman; Work; anti-retroviral therapy, highly active; cohort; cost effectiveness; flexibility; hepatitis non A non B; hepatitis nonA nonB; interest; non A non B hepatitis; non A, non B hepatitis; non-A non-B hepatitis; non-A, non-B hepatitis; organizational structure; response; sharing data; substance use; success",Women's Interagency HIV Study (WIHS) IV,,35004,ZAI1,Special Emphasis Panel,,17,3419792,
7760849,U01,AI,5,,01/01/2010,12/31/2010,AI-07-004,5U01AI042590-13,,NIAID:1983598;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"GANGE, STEPHEN JOHN;",1936970;,5U01AI042590,11/01/1997,12/31/2012,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Antiretroviral Therapy, Highly Active; Archives; Biological; Characteristics; Cohort Studies; Communication; Concurrent Studies; Data; Data Banks; Data Bases; Data Collection; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Discipline; Documentation; Epidemiology; HAART; HIV; HIV Infections; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Investigators; LAV-HTLV-III; Leadership; Lymphadenopathy-Associated Virus; Method LOINC Axis 6; Methodology; Methods; Monitor; Natural History; On-Line Systems; Online Systems; Operation; Operative Procedures; Operative Surgical Procedures; Pathogenesis; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; Reporting; Research; Research Design; Research Personnel; Research Specimen; Researchers; Scientific Publication; Specimen; Study Type; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Training; Transmission; Virus-HIV; Woman; anti-retroviral therapy, highly active; clinical data repository; clinical data warehouse; clinical research site; clinical site; cohort; data management; data repository; design; designing; novel; online computer; programs; quality assurance; relational database; repository; study design; surgery; transmission process; web based; working group",WIHS Data Management and Analysis Center (WDMAC),,42590,ZAI1,Special Emphasis Panel,,13,1983598,
7761755,U01,AI,5,,02/01/2010,01/31/2011,,5U01AI051986-07,,NIAID:388769;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PHILADELPHIA,UNITED STATES,,02,075524595,US,PA,191044265,WISTAR INSTITUTE,"MONTANER, LUIS J.;",1959455;,5U01AI051986,07/01/2003,01/31/2011,Clinic; HIV therapy; Interruption; Research Resources; Resources,HIV Therapy & Interruption RCT in Resource Poor Clinic,,51986,ZRG1,Special Emphasis Panel,,7,388769,
7763182,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069399-04,,NIAID:984268;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHIANG MAI,THAILAND,,,660994984,TH,,50202,CHIANG MAI UNIVERSITY,"SIRISANTHANA, THIRA ;",7042757;,5U01AI069399,03/15/2007,01/31/2014,"0-11 years old; AIDS; AIDS Virus; AIDS clinical trial group; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adolescent; Adolescent Youth; Armed Forces Personnel; Asia; Blood donor; Child; Child Youth; Children (0-21); China; Clinic; Clinical; Clinical Cooperative Groups; Clinical Management; Clinical Trial Groups; Clinical Trials Cooperative Group; Clinical Trials Unit; Communicable Diseases; Communities; Country; County; Couples; Discipline of obstetrics; Disease Marker; Epidemic; Faculty; Foundations; Grant; HIV; HIV Infections; HIV Prevention; HIV Vaccine Trials Network; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Sciences; Housing; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Child; Immunologic Deficiency Syndrome, Acquired; India; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infrastructure; Injecting drug user; Injection Drug User; LAV-HTLV-III; Laboratories; Lead; Lymphadenopathy-Associated Virus; Mainland China; Medicine; Military; Military Personnel; Monitor; NIAID; NICHD; NIDA; NIMH; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Mental Health (U.S.); Obstetrics; Patients; Pb element; Pharmacies; Pharmacy facility; Population; Pregnant Women; Principal Investigator; Process; Public Health; R01 Mechanism; R01 Program; RPG; Research; Research Grants; Research Infrastructure; Research Institute; Research Priority; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Science of Medicine; Shipping; Ships; Site; Study of epidemiology; T-Lymphotropic Virus Type III Infections, Human; Thailand; Translational Research; Translational Research Enterprise; Translational Science; United States National Institute of Mental Health; Universities; Vertical Disease Transmission; Vertical Transmission; Viet Nam; Vietnam; Vietnam, Republic of; Virus-HIV; Walking; children; clinical research site; clinical site; data management; epidemiology study; experience; heavy metal Pb; heavy metal lead; juvenile; juvenile human; male; mother to child transmission; public health medicine (field); sample collection; sex; specimen collection; translation research enterprise; youngster",Chiang Mai University HIV/AIDS Clinical Trials Unit,,69399,ZAI1,Special Emphasis Panel,,4,984268,
7752812,U01,AI,5,,01/01/2010,12/31/2010,AI-05-002,5U01AI069409-04,,NIAID:50082;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,KINGSTON,JAMAICA,,,873270800,JM,,876,EPIDEMIOLOGY RESEARCH AND TRAINING UNIT,"FIGUEROA, JOHN P;",8380993;,5U01AI069409,02/01/2007,12/31/2013,"0-11 years old; 21+ years old; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Adolescent; Adolescent Youth; Adult; Agreement; Antiretroviral Therapy, Highly Active; Caribbean Islands; Child; Child Youth; Childhood; Children (0-21); Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Network; Clinical Trials, Unspecified; Data Set; Dataset; Drugs; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Ethics; HAART; HIV; HIV Vaccine Trials Network; HIV vaccine; HIV/AIDS; HIV/AIDS Vaccines; HIV/AIDS problem; HTLV-III; Health; Highly Active Antiretroviral Therapy; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Infant; International; Investigators; Jamaica; LAV-HTLV-III; Laboratories; Lead; Lymphadenopathy-Associated Virus; Medication; Minority; Pb element; Perinatal; Pharmaceutic Preparations; Pharmaceutical Preparations; Population; Pregnant Women; Preparedness; Prevalence; Preventive; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Readiness; Regimen; Regulation; Research; Research Personnel; Research Training; Researchers; Safety; System; System, LOINC Axis 4; Universities; Vaccines; Virus-HIV; West Indies; Woman; adult human (21+); anti-retroviral therapy, highly active; base; children; clinical investigation; clinical practice; clinical research site; clinical site; cohort; cost efficient; drug/agent; experience; heavy metal Pb; heavy metal lead; high risk men; human immunodeficiency virus vaccine; immunogenicity; improved; juvenile; juvenile human; men at high risk; microbicidal; microbicide; pediatric; pregnant; professor; programs; public health medicine (field); youngster",HIV/AIDS Clinical Trials in Jamaica,,69409,ZAI1,Special Emphasis Panel,,4,50082,
7762852,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069417-04,,NIAID:1405928;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PUNE,INDIA,,,915223064,IN,,411026,NATIONAL AIDS RESEARCH INSTITUTE,"MEHENDALE, SANJAY M;",8382503;,5U01AI069417,08/15/2007,01/31/2014,"AIDS; AIDS Vaccines; AIDS Virus; AIDS clinical trial group; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Acute; Applied Research; Applied Science; Award; Basic Research; Basic Science; Cities; Clinical; Clinical Management; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Clinical Trials, Unspecified; Conduct Clinical Trials; Coupled; Descriptive Epidemiology; Development and Research; Documentation; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epidemiology, Descriptive; Funding; Grant; HIV; HIV Infections; HIV Vaccine Trials Network; HIV prevention trials network; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health, Reproductive; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Incidence; India; Individual; Infrastructure; International; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Medical Research; Morbidity; Morbidity - disease rate; NIH; NIH RFA; National Institutes of Health; National Institutes of Health (U.S.); Nodal; Phase; Population; Preparation; Prevalence; Prevention; R & D; R&D; Reproduction; Reproductive Health; Request for Applications; Research; Research Infrastructure; Research Institute; Research Priority; Research, Medical; Risk Factors; Sexual Health; Site; T-Lymphotropic Virus Type III Infections, Human; Transmission; United States National Institutes of Health; V75; VNT; VTN; VTN gene; Vaccine Research; Vaccines; Virus-HIV; Vitronectin Gene; Work; clinical investigation; clinical research site; clinical site; experience; follow-up; microbicidal; microbicide; research and development; response; transmission process; vaccine evaluation; vaccine screening; vaccine testing","National AIDS Research Institute (NARI), Pune, INDIA: Clinical Trials Unit",,69417,ZAI1,Special Emphasis Panel,,4,1405928,
7763830,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069422-04,,NIAID:7068878;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CAPE TOWN,SOUTH AFRICA,,,635909489,SF,,,MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA,"RAMJEE, GITA ;",6613452;,5U01AI069422,03/01/2007,01/31/2014,"AIDS Seroconversion; AIDS Seropositivity; AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Address; Affect; Anti-HIV Positivity; Behavioral Research; Caring; Clinical; Clinical Trials Unit; Communities; Counseling; Data; Ensure; Epidemic; Ethics; HIV; HIV Antibody Positivity; HIV Positive; HIV Positivity; HIV Prevention; HIV Seroconversion; HIV Seropositivity; HIV prevention trial; HIV/AIDS; HIV/AIDS prevention; HIV/AIDS problem; HIV/STD; HTLV-III; HTLV-III Seroconversion; HTLV-III Seropositivity; Home; Home environment; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, General; Incidence; Individual; Intervention; Intervention Strategies; LAV-HTLV-III; Leadership; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Operation; Operative Procedures; Operative Surgical Procedures; Organization Charts; Population; Populations at Risk; Position; Positioning Attribute; Prevalence; Prevention; Prevention education; Programs (PT); Programs [Publication Type]; Republic of South Africa; Research; Research Resources; Resources; Screening procedure; South Africa; Surgical; Surgical Interventions; Surgical Procedure; Training and Infrastructure; Union of South Africa; Virus-HIV; antibody positive AIDS test; antigen positive AIDS test; base; clinical research site; clinical site; flexibility; interdisciplinary approach; interventional strategy; organizational structure; prevention clinical trial; programs; response; screening; screenings; seropositive (AIDS test); surgery",South Africa MRC HIV Prevention Trials Unit,,69422,ZAI1,Special Emphasis Panel,,4,7068878,
7764724,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069429-04,,NIAID:136242;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PARIS,FRANCE,,,492499660,FR,,75010,INSTITUTE OF RESEARCH AND DEVELOPMENT,"LALLEMANT, MARC J;",1900185;,5U01AI069429,05/01/2007,01/31/2014,"0-11 years old; 21+ years old; AIDS; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Active Follow-up; Address; Adolescent; Adolescent Youth; Adult; Affect; Anti-Retroviral Agents; Antiretroviral Agents; Area; Child; Child Youth; Children (0-21); Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Collaborations; Communities; Environment; Guidelines; HIV; HIV Infections; HIV Prevention; HIV/AIDS prevention; HOSP; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Care Providers; Health Personnel; Healthcare Providers; Healthcare Systems; Healthcare worker; Hospitals; Hospitals, Public; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; IMPAACT; Immunologic Deficiency Syndrome, Acquired; Infrastructure; International; Investigators; Knowledge; LAV-HTLV-III; Leadership; Lymphadenopathy-Associated Virus; Methods; Mission; Monitor; Patients; Population; Programs (PT); Programs [Publication Type]; Public Health; Public Hospitals; Research; Research Activity; Research Infrastructure; Research Personnel; Researchers; Site; Structure; Systems, Health Care; T-Lymphotropic Virus Type III Infections, Human; Thailand; Vertical Disease Transmission; Vertical Transmission; Virus-HIV; adult human (21+); anti-retroviral; antiretroviral; base; care giving; caregiving; children; clinical investigation; clinical research site; clinical site; cohort; follow-up; health care personnel; health care worker; health provider; healthcare personnel; improved; juvenile; juvenile human; medical personnel; mother to child transmission; prevent; preventing; programs; public health medicine (field); scale up; treatment program; treatment provider; youngster","Program for HIV Prevention and Treatment-Clinical Trial Unit, Thailand",,69429,ZAI1,Special Emphasis Panel,,4,136242,
7764678,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069443-04,,NIAID:368149;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,LAUSANNE,SWITZERLAND,,,481700292,SZ,,1011,CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS,"PANTALEO, GIUSEPPE ;",2103409;,5U01AI069443,02/01/2007,01/31/2014,"AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Antiviral Agents; Antiviral Drugs; Antivirals; Cellular Immunology; Clinical; Clinical Immunology; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Clinics and Hospitals; Clinics or Hospitals; Commit; Communicable Diseases; Country; Development; Development and Research; Ethnic Origin; Ethnicity; Ethnicity aspects; European; Future; HIV; HIV Infections; HIV Vaccine Trials Network; HIV vaccine; HIV-1; HIV-I; HIV/AIDS Vaccines; HIV1; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; International; Italy; LAV-HTLV-III; Laboratories; Laboratory Research; Link; Location; Lymphadenopathy-Associated Virus; Malaria; Monitor; NIAID; NIH; National Institute of Allergy and Infectious Disease; National Institutes of Health; National Institutes of Health (U.S.); Paludism; Phase; Plasmodium Infections; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; R & D; R&D; Records; Research, Laboratory; Risk; Solutions; Spain; Switzerland; T-Cells; T-Lymphocyte; T-Lymphotropic Virus Type III Infections, Human; Thymus-Dependent Lymphocytes; Tuberculosis; United States National Institutes of Health; Universities; Vaccine Clinical Trial; Vaccines; Virus-HIV; Woman; clinical investigation; cohort; disseminated TB; disseminated tuberculosis; experience; human T cell leukemia virus III; human T lymphotropic virus III; human immunodeficiency virus vaccine; improved; pandemic; pandemic disease; programs; research and development; response; thymus derived lymphocyte; tuberculous spondyloarthropathy; vaccin; vaccin protein; vaccine candidate; volunteer",South-West European HIV Vaccine Clinical Trial Unit,,69443,ZAI1,Special Emphasis Panel,,4,368149,
7762763,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069453-04,,NIAID:4814166;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,JOHANNESBURG,SOUTH AFRICA,,,639391218,SF,,,"WITS HEALTH CONSORTIUM (PTY), LTD","GRAY, GLENDA ;",10394601;,5U01AI069453,02/15/2007,01/31/2014,"0-11 years old; 21+ years old; AIDS; AIDS Virus; AIDS clinical trial group; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adolescent; Adolescent Youth; Adult; Africa, Southern; Area; Articulation; Caring; Child; Child Youth; Childhood; Children (0-21); Chronic; Clinical Management; Clinical Trials; Clinical Trials Unit; Clinical Trials, Therapy; Clinical Trials, Unspecified; Communities; Disadvantaged; Disease; Disorder; Epidemic; Funding; Gender; HIV; HIV Vaccine Trials Network; HIV-1; HIV-I; HIV/AIDS; HIV/AIDS problem; HIV1; HTLV-III; Health; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus 1; Human, Adult; Human, Child; IMPAACT; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Industry; Infection; Intervention; Intervention Strategies; Investigators; Joints; LAV-HTLV-III; Leadership; Life; Lymphadenopathy-Associated Virus; Meningeal; Morbidity; Morbidity - disease rate; NIH; National Institutes of Health; National Institutes of Health (U.S.); Perinatal; Phase; Population; Prevention; Prevention Research; Preventive; Recording of previous events; Republic of South Africa; Research; Research Personnel; Research Priority; Researchers; Site; South Africa; Southern Africa; Therapeutic; Therapeutic Human Experimentation; Therapeutic Research; Therapeutic Trials; Therapy Clinical Trials; Time; Translational Research; Translational Research Enterprise; Translational Science; Union of South Africa; United States National Institutes of Health; Universities; Vaccine Research; Virus-HIV; adult human (21+); antiretroviral therapy; base; burden of disease; burden of illness; children; clinical investigation; disease burden; disease/disorder; drug development; experience; high risk; human T cell leukemia virus III; human T lymphotropic virus III; innovate; innovation; innovative; interventional strategy; juvenile; juvenile human; pathogen; pediatric; prevent; preventing; respiratory; therapeutic vaccine; translation research enterprise; treatment strategy; vaccine development; years of life lost to disability; years of life lost to disease; youngster",Soweto Clinical Trials Unit,,69453,ZAI1,Special Emphasis Panel,,4,4814166,
7760897,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069463-04,,NIAID:3607545;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,JOHANNESBURG,SOUTH AFRICA,,,639391218,SF,,,"WITS HEALTH CONSORTIUM (PTY), LTD","SANNE, IAN MATTHIAS;",8623491;,5U01AI069463,03/15/2007,01/31/2014,"0-11 years old; 21+ years old; AIDS Virus; AIDS clinical trial group; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Acute; Adolescent; Adolescent Youth; Adult; Area; Child; Child Youth; Children (0-21); Clinical Management; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Clinical Trials, Unspecified; Collaborations; Commit; Data Quality; Development; Development and Research; Ethics Committees, Research; HIV; HIV Infections; HIV Prevention; HIV Vaccine Trials Network; HIV vaccine; HIV/AIDS; HIV/AIDS Vaccines; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; IMPAACT; IRBs; Institution; Institutional Review Boards; International; Investigators; LAV-HTLV-III; Leadership; Letters; Link; Lymphadenopathy-Associated Virus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Pharmacies; Pharmacy facility; Prevention; Protocol; Protocols documentation; Quality, Data; R & D; R&D; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Site; T-Lymphotropic Virus Type III Infections, Human; Therapeutic Clinical Trial; Training; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Universities; Vaccine Research; Vaccines; Vertical Disease Transmission; Vertical Transmission; Virus-HIV; Wit; Work; adult human (21+); children; clinical investigation; clinical research site; clinical site; drug development; human immunodeficiency virus vaccine; juvenile; juvenile human; microbicidal; microbicide; mother to child transmission; research and development; translation research enterprise; youngster",Units for HIV/AIDS Clinical Trials Networks,,69463,ZAI1,Special Emphasis Panel,,4,3607545,
7764742,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069466-04,,NIAID:29226;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,NEW YORK,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"EL-SADR, WAFAA M.;",1875355;,5U01AI069466,03/01/2007,01/31/2014,"AIDS; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affect; African American; Afro American; Afroamerican; Behavioral; Black Populations; Black or African American; Blood; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Communities; Community Education; Community Health Education; Community Health Taining; Community HealthTutoring; Data Collection; Dentistry; Discipline; Ensure; Epidemic; Ethics; HIV; HIV Infections; HIV Prevention; HIV prevention trial; HIV/AIDS prevention; HOSP; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health Education, Community; Hispanic Populations; Hispanics; Hispanics or Latinos; Hospitals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Intervention; Intervention Strategies; Investigators; LAV-HTLV-III; Latino Population; Lebanon; Lymphadenopathy-Associated Virus; Medicine; Methods; Microbicide Trials Network; New Jersey; New York; New York City; Participant; Population; Populations at Risk; Prevention; Process; Protocol; Protocols documentation; Public Health Schools; Research; Research Personnel; Researchers; Reticuloendothelial System, Blood; Schools, Public Health; Science of Medicine; Scientific Advances and Accomplishments; Site; Spanish Origin; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Trust; Universities; Virus-HIV; Woman; Work; black American; clinical investigation; clinical research site; clinical site; experience; high risk; hispanic community; innovate; innovation; innovative; interventional strategy; microbicidal; microbicide; prevent; preventing; quality assurance; scientific accomplishments; scientific advances; skills; working group",Centers for Innovative Research to Control AIDS,,69466,ZAI1,Special Emphasis Panel,,4,29226,
7762804,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069469-04,,NIAID:4427390;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,DURBAN,SOUTH AFRICA,,,637360244,SF,,3630,UNIVERSITY OF KWAZULU-NATAL,"ABDOOL KARIM, SALIM S;",6521145;,5U01AI069469,03/01/2007,01/31/2014,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Adherence; Adherence (attribute); Adolescent; Adolescent Youth; Advisory Committees; African; Area; Au element; Beds; Bioethics; Clinic; Clinical Management; Clinical Trials; Clinical Trials Unit; Clinical Trials, Monitoring; Clinical Trials, Phase I; Clinical Trials, Unspecified; Communication; Communities; Country; Early-Stage Clinical Trials; Ensure; Ethics, Biomedical; Gestation; Gold; HIV; HIV Vaccine Trials Network; HIV/AIDS; HIV/AIDS problem; HOSP; HTLV-III; Health; Hospitals; Human Immunodeficiency Viruses; Human Resources; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; IMPAACT; Immunologic Deficiency Syndrome, Acquired; Incidence; Infrastructure; Institution; Investigators; LAV-HTLV-III; Laboratories; Lead; Leadership; Lymphadenopathy-Associated Virus; Manpower; Medical Research; Monitor; Monitoring Clinical Trials; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Pb element; Performance; Persons; Pharmacies; Pharmacy facility; Phase 1 Clinical Trials; Phase I Clinical Trials; Phase I Study; Pregnancy; Prevalence; Prevention; Programs (PT); Programs [Publication Type]; Recruitment Activity; Republic of South Africa; Research; Research Infrastructure; Research Institute; Research Personnel; Research Priority; Research, Medical; Researchers; Risk; Rural Community; Science of Statistics; Site; South Africa; Statistics; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Task Forces; Time; Training; Training Programs; Union of South Africa; Universities; Vaccines; Virus-HIV; Woman; base; behavioral health; clinical investigation; cohort; data management; experience; health economics; heavy metal Pb; heavy metal lead; implementation trial; juvenile; juvenile human; meetings; microbicidal; microbicide; personnel; phase 1 study; phase 1 trial; phase I trial; programs; protocol, phase I; quality assurance; recruit; sex; statistics; surgery; treatment trial",University of KwaZulu-Natal - CAPRISA HIV/AIDS Clinical Trials Unit,,69469,ZAI1,Special Emphasis Panel,,4,4427390,
7762789,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069482-04,,NIAID:1386714;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"JACKSON, JAY B;",1903068;,5U01AI069482,07/01/2007,01/31/2014,"0-11 years old; 21+ years old; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adult; Area; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Child; Child Youth; Children (0-21); China; Chinese; Chinese People; Cities; Clinic; Clinical Management; Clinical Trials Unit; Collaborations; Conduct Clinical Trials; County; Data; Ethics Committees, Research; HIV; HIV Infections; HIV Prevention; HIV Seroprevalence; HIV prevention trial; HIV vaccine; HIV/AIDS Vaccines; HIV/AIDS prevention; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; IRBs; IVDU; Infrastructure; Institutional Review Boards; Intervention Trial; Investigators; LAV-HTLV-III; Laboratories; Lymphadenopathy-Associated Virus; Mainland China; Morbidity; Morbidity - disease rate; PROV; Persons; Pharmacies; Pharmacy facility; Phase; Population; Principal Investigator; Province; Randomized; Research Ethics Committees; Research Infrastructure; Research Personnel; Researchers; SCHED; Schedule; Site; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; Training; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Universities; Users, IV Drug; Viet Nam; Vietnam; Vietnam, Republic of; Viral Burden; Viral Load; Viral Load result; Virus-HIV; adult human (21+); base; children; clinical research site; clinical site; cost; data management; human immunodeficiency virus vaccine; intravenous drug user; prevent; preventing; randomisation; randomization; randomly assigned; youngster","Johns Hopkins University-Guangxi, China Clinical Trials Unit",,69482,ZAI1,Special Emphasis Panel,,4,1386714,
7749031,U01,AI,5,,01/01/2010,12/31/2010,AI-05-002,5U01AI069486-04,,NIAID:437324;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,SANTO DOMINGO,DOMINICAN REP,,,871477162,DR,,01090,INSTITUTO DERMATOLOGICO CIRUGIA DE PIEL,"DONASTORG, YEYCY A.;",8708476;,5U01AI069486,02/15/2007,12/31/2013,"AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Awareness; Awarenesses; Behavior; Behavioral; Clinical; Clinical Trials; Clinical Trials, Unspecified; Cognitive Discrimination; Communities; Community Education; Community Health Education; Community Health Taining; Community HealthTutoring; Conduct Clinical Trials; Development; Discrimination; Discrimination (Psychology); Dominican Republic; Epidemic; HIV; HIV Prevention; HIV Vaccine Trials Network; HIV vaccine; HIV/AIDS; HIV/AIDS Vaccines; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; Health Education, Community; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Incidence; Investigation; Investigators; LAV-HTLV-III; Laboratories; Leadership; Life; Lymphadenopathy-Associated Virus; Mission; NIH; National Institutes of Health; National Institutes of Health (U.S.); Phase; Population; Population Group; Prevention; Preventive; Programs (PT); Programs [Publication Type]; Public Health; Research Personnel; Researchers; Risk; Risk-Taking; Running; Safety; Site; Stigmata; Structure; Target Populations; United States; United States National Institutes of Health; Vaccine Clinical Trial; Vaccine Research; Vaccines; Virus-HIV; clinical investigation; high risk; human immunodeficiency virus vaccine; immunogenicity; improved; programs; public health medicine (field); social; social stigma; stigma; vaccine candidate",Development of HIV Vaccine Clinical Trials Phase I-II-III in Dominican Republic,,69486,ZAI1,Special Emphasis Panel,,4,437324,
7765616,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069503-04,,NIAID:3304724;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WASHINGTON,UNITED STATES,INTERNAL MEDICINE/MEDICINE,00,043990498,US,DC,20052,GEORGE WASHINGTON UNIVERSITY,"GORDIN, FRED M;",2409100;,5U01AI069503,06/15/2007,01/31/2014,"AIDS; AIDS Virus; AIDS/HIV; AIDS/HIV problem; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Affect; Anti-Retroviral Agents; Antiretroviral Agents; Behavioral; Brazil; Canada; Cardiovascular Diseases; Caring; Clinical Management; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Cocaine Users; Collaborations; Communities; Disease; Disorder; District of Columbia; Drugs; Enrollment; HIV; HIV Infections; HIV prevention trial; HIV prevention trials network; HIV/AIDS; HIV/AIDS problem; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Hepatitis Viruses; Heterogeneity, Population; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Immunologic Deficiency Syndrome, Acquired; Individual; Infection; Institution; International Network for Strategic Initiatives in Global HIV Trials; LAV-HTLV-III; Life; Lymphadenopathy-Associated Virus; Medical center; Medication; Medicine; Opportunistic Infections; Outcome; Patients; Persons; Peru; Pharmaceutic Preparations; Pharmaceutical Preparations; Population Heterogeneity; Prevention; Principal Investigator; Programs (PT); Programs [Publication Type]; Public Health; Randomized Clinical Trials; Republic of South Africa; Research; Risk; Risk Behaviors; Risky Behavior; Science of Medicine; Site; South Africa; T-Lymphotropic Virus Type III Infections, Human; Target Populations; Therapeutic Intervention; Training and Education; Transmission; Trials, Randomized Clinical; Union of South Africa; United States; Universities; Users, Cocaine; Veterans; Virus-HIV; Washington; Washington, D.C.; Washington, DC; anti-retroviral; antiretroviral; at risk behavior; base; cardiovascular disorder; clinical investigation; clinical relevance; clinically relevant; disease/disorder; diverse populations; drug/agent; enroll; experience; heterogeneous population; high risk; intervention therapy; member; programs; public health medicine (field); transmission process",CPCRA Clinical Trials Unit,,69503,ZAI1,Special Emphasis Panel,,4,3304724,
7743498,U01,AI,5,,12/01/2009,11/30/2010,AI-05-002,5U01AI069516-04,,NIAID:765163;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,WORCESTER,UNITED STATES,PEDIATRICS,03,603847393,US,MA,01655,UNIV OF MASSACHUSETTS MED SCH WORCESTER,"LUZURIAGA, KATHERINE F;",1892938;,5U01AI069516,02/01/2007,11/30/2013,"0-11 years old; AIDS; AIDS Virus; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Youth; Child; Child Youth; Childhood; Children (0-21); Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Clinical Trials, Unspecified; Connecticut; Development; Funding; Goals; HIV-1; HIV-I; HIV1; Human immunodeficiency virus 1; Human, Child; Immunodeficiency Virus Type 1, Human; Immunologic Deficiency Syndrome, Acquired; Infection; International; Investigators; Leadership; Massachusetts; Medical center; Mentorship; Morbidity; Morbidity - disease rate; Mothers; New England; Northeastern United States; Pathogenesis; Performance; Play; Prevention; Prevention strategy; Preventive; Preventive strategy; Protocol; Protocols documentation; Research Personnel; Researchers; Role; Schools, Medical; Site; Toxic effect; Toxicities; Training; Translational Research; Translational Research Enterprise; Translational Science; Transmission; Universities; Vaccines; Work; base; children; clinical care; clinical investigation; clinical research site; clinical site; design; designing; drug development; experience; human T cell leukemia virus III; human T lymphotropic virus III; improved; juvenile; juvenile human; medical schools; pediatric; pediatric human immunodeficiency virus; response; social role; translation research enterprise; transmission process; treatment strategy; youngster",Western New England Maternal Pediatric Adolescent AIDS Clinical Trials Unit,,69516,ZAI1,Special Emphasis Panel,,4,765163,
7763159,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069519-04,,NIAID:1;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,RONDEBOSCH,SOUTH AFRICA,,,568227214,SF,,7700,UNIVERSITY OF CAPE TOWN,"WOOD, ROBIN ;",7551736;,5U01AI069519,04/01/2007,01/31/2014,"AIDS Virus; AIDS prevention; AIDS/HIV; AIDS/HIV prevention; AIDS/HIV problem; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Administrative Management; Adolescent; Adolescent Youth; Area; Award; Caring; Clinical Management; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Collaborations; Communities; Complement; Complement Proteins; Conduct Clinical Trials; Development and Research; Funding; Grant; HIV; HIV Prevention; HIV Vaccine Trials Network; HIV vaccine; HIV/AIDS; HIV/AIDS Vaccines; HIV/AIDS prevention; HIV/AIDS problem; HTLV-III; History; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Infectious Disease Epidemiology; Infectious Epidemiology; LAV-HTLV-III; Laboratories; Leadership; Link; Location; Lymphadenopathy-Associated Virus; Mentors; Morbidity; Morbidity - disease rate; Office of Administrative Management; Operation; Operative Procedures; Operative Surgical Procedures; Perinatal; Phase; Preventive Intervention; Psychiatry; R & D; R&D; Recording of previous events; Republic of South Africa; Research; Research Activity; Robin; Robin bird; Science of Virology; Site; South Africa; Structure; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Training; Union of South Africa; Universities; Vaccine Research; Virology; Virus-HIV; Wood; Wood material; antiretroviral therapy; base; clinical investigation; clinical research site; clinical site; data management; human immunodeficiency virus vaccine; juvenile; juvenile human; microbicidal; microbicide; preventional intervention strategy; professor; research and development; surgery; virology",Cape Town Clinical Trials Unit (CT-CTU) for HIV/AIDS Prevention & Treatment,,69519,ZAI1,Special Emphasis Panel,,4,1,
7769914,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069521-04,,NIAID:835675;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,TYGERBERG,SOUTH AFRICA,,,569118040,SF,,7505,STELLENBOSCH UNIVERSITY TYGERBERG CAMPUS,"COTTON, MARK FREDRIC;",8629697;,5U01AI069521,04/15/2007,01/31/2014,"0-11 years old; 12-20 years old; 21+ years old; 4-Pyridinecarboxylic acid, hydrazide; AIDS; AIDS Virus; AIDS clinical trial group; AIDS in Pediatric Population; AIDS test; AIDS/HIV; AIDS/HIV problem; AIDS/HIV test; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immune Deficiency Syndrome Virus; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome Virus; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Anti-Retroviral Agents; Antiretroviral Agents; Cell Nucleus; Child; Child Youth; Childhood; Children (0-21); Clinic; Clinical Trials Unit; Colorado; Communicable Diseases; Community Health; Discipline of obstetrics; Enrollment; Faculty; Funding; HBV Vaccine; HIV; HIV test; HIV/AIDS; HIV/AIDS problem; HOSP; HTLV-III; Health Sciences; Hepatitis B Vaccines; Hepatitis B virus vaccine; High Prevalence; Hospitals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human immunodeficiency virus test; Human, Adult; Human, Child; IMPAACT; Immunologic Deficiency Syndrome, Acquired; Incidence; Industry; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Investigators; Isonicotinic Acid Hydrazide; LAV-HTLV-III; Lymphadenopathy-Associated Virus; Mentors; NNRTI; Neonatology; Nucleus; Obstetrics; Patients; Pediatric Neurology; Perinatal; Phase Transition; Population; Pregnant Women; Prevention; Programs (PT); Programs [Publication Type]; Recruitment Activity; Republic of South Africa; Research; Research Personnel; Researchers; Role; Site; South Africa; System; System, LOINC Axis 4; Time; Tuberculosis; Union of South Africa; Universities; Vertical Disease Transmission; Vertical Transmission; Virus-HIV; Wife; Woman; adolescence (12-20); adult human (21+); anti-retroviral; antiretroviral; antiretroviral therapy; children; clinical research site; clinical site; disseminated TB; disseminated tuberculosis; enroll; isoniazid; juvenile; juvenile human; metropolitan; mother to child transmission; non-nucleoside RT inhibitors; non-nucleoside reverse transcriptase inhibitors; nonnucleoside reverse transcriptase inhibitors; pediatric; pediatric AIDS; prevent; preventing; programs; protocol development; recruit; social role; teenage; tertiary care; trial comparing; tuberculous spondyloarthropathy; youngster","Stellenbosch University Clinical Trial Unit, Cape Town, South Africa",,69521,ZAI1,Special Emphasis Panel,,4,835675,
7763899,U01,AI,5,,02/01/2010,01/31/2011,AI-05-002,5U01AI069530-04,,NIAID:3405405;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BALTIMORE,UNITED STATES,PATHOLOGY,07,001910777,US,MD,21218,JOHNS HOPKINS UNIVERSITY,"FOWLER, MARY GLENN;",8772391;,5U01AI069530,02/05/2007,01/31/2014,"0-11 years old; 21+ years old; AIDS Virus; AIDS prevention; AIDS/HIV prevention; Access to Care; Access to Health Care; Access to Healthcare; Accessibility of health care; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Adult; Area; Availability of Health Services; Breast Feeding; Breastfeeding; Child; Child Youth; Children (0-21); Clinic; Clinical Data; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Collaborations; Communicable Diseases; Communities; Coupled; Disadvantaged; Education; Educational aspects; Enrollment; Epidemic; Ethics; Ethics Committees, Research; Funding; Gestation; Goals; HIV; HIV Infections; HIV Prevention; HIV therapy; HIV vaccine; HIV/AIDS Vaccines; HIV/AIDS prevention; HOSP; HTLV-III; HTLV-III Infections; HTLV-III-LAV Infections; Health; Health Services Accessibility; Hospitals; Human; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Human, Adult; Human, Child; Human, General; IMPAACT; IRBs; Infection; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Infrastructure; Institutes; Institutional Review Boards; Investigators; LAV-HTLV-III; Laboratories; Lymphadenopathy-Associated Virus; Man (Taxonomy); Man, Modern; Medical; Participant; Pregnancy; Programs (PT); Programs [Publication Type]; Public Health; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Site; T-Lymphotropic Virus Type III Infections, Human; Transmission; Uganda; Universities; Virus-HIV; Woman; access to services; access to treatment; adult human (21+); availability of services; base; children; clinical investigation; clinical research site; clinical site; data management; enroll; experience; health care availability; health care service access; health care service availability; health services availability; healthcare access availability; healthcare service access; healthcare service availability; human immunodeficiency virus vaccine; international center; microbicidal; microbicide; neonate; prevent; preventing; programs; public health medicine (field); response; transmission process; treatment trial; youngster","Makerere Univ.-Johns Hopkins Univ. HIV Clinical Trials Unit-Kampala, Uganda",,69530,ZAI1,Special Emphasis Panel,,4,3405405,
7751847,U01,AI,5,,01/01/2010,12/31/2010,AI-05-002,5U01AI069554-04,,NIAID:588324;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHICAGO,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,098987217,US,IL,60612,UNIVERSITY OF ILLINOIS AT CHICAGO,"NOVAK, RICHARD M;",2455041;,5U01AI069554,02/01/2007,12/31/2013,"AIDS Virus; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; African American; Afro American; Afroamerican; Agreement; Area; Black Populations; Black or African American; Chicago; Clinic; Clinical Trials; Clinical Trials Unit; Clinical Trials, Unspecified; Drugs, Investigational; Funding; HIV; HIV Vaccine Trials Network; HIV vaccine; HIV/AIDS Vaccines; HOSP; HTLV-III; High Risk Woman; Hospitals; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Illinois; Immunity, Mucosal; Incidence; Investigational Drugs; Investigational New Drugs; LAV-HTLV-III; Laboratories; Laboratories, Hospital; Leadership; Letters; Lymphadenopathy-Associated Virus; Medical center; Mucosal Immunity; PBMC; Peripheral Blood Mononuclear Cell; Pharmaceutical Services; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Records; Research; Research Priority; Sampling; Services; Services, Pharmaceutic; Services, Pharmacy; Target Populations; Universities; Virus-HIV; Woman; black American; clinical investigation; clinical research site; clinical site; hospital laboratories; human immunodeficiency virus vaccine; microbicidal; microbicide; programs; vaccine effectiveness; women at high risk",Targeting High-Risk Women for HVTN and Microbicide Trials,,69554,ZAI1,Special Emphasis Panel,,4,588324,
7784500,U01,AI,5,,03/01/2010,02/28/2011,AI-08-003,5U01AI082457-02,,NIAID:730719;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,PALO ALTO,UNITED STATES,,14,624218814,US,CA,943040038,"PALO ALTO INSTITUTE FOR RES & EDU, INC.","LIAO, JOSEPH C;",7598926;,5U01AI082457,03/15/2009,02/28/2014,"Assay; Bioassay; Biologic Assays; Biological Assay; Biometrics; Biometry; Biometry and Biostatistics; Biosensor; Biostatistics; Care Technology Points; Care, Health; Centrifugation; Clinical; Clinical Microbiology; Collaborations; Cytolysis; Detection; Development Plans; Diagnosis; Diagnostic; Electrodes; Figs; Figs - dietary; Fractionation, Centrifugation; Future; Goals; Healthcare; Industry; Laboratories; Lysis; Manuals; Microfluidic; Microfluidics; Molecular; Operation; Operative Procedures; Operative Surgical Procedures; Patients; Plans, Development; Principal Investigator; Process; Reagent; Research; Research Proposals; Ribosomal RNA; Sampling; Speed; Speed (motion); Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems Integration; Technology; Technology Points, Care; Time; UTI; Urinary System, Urine; Urinary tract infection; Urinary tract infectious disease; Urine; Urology; Uropathogen; Validation; biochip; detector; industry partner; innovate; innovation; innovative; pathogen; point of care; point of care technology; product development; rRNA; sensor (biological); statistics/biometry; surgery; technology development",An Integrated Diagnostic Biochip for Point of Care Pathogen Identification,,82457,ZAI1,Special Emphasis Panel,,2,730719,
7766912,U01,DC,5,,02/01/2010,01/31/2011,PAR-07-128,5U01DC008423-03,,NIDCD:711176;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,ANN ARBOR,UNITED STATES,OTOLARYNGOLOGY,15,073133571,US,MI,481091274,UNIVERSITY OF MICHIGAN AT ANN ARBOR,"MILLER, JOSEF MAYER;",1871197;,5U01DC008423,02/01/2008,01/31/2012,"Address; Adverse Experience; Adverse effects; Adverse event; Animal Welfare; Animals; Antioxidants; Arts; Bibliography; Clinical; Clinical Evaluation; Clinical Testing; Clinical Trials; Clinical Trials, Unspecified; Combined Modality Therapy; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Communication Disorders; Communication impairment; Communicative Disorders; Consumption; Country; Critiques; Data; Doctor of Philosophy; Dose; Drug Formulations; Drugs; Ecological impact; Editorial Comment; Editorial Comment (PT); Engineering; Engineerings; Environment; Environmental Impact; Equipment; Ethics Committees, Research; Evaluation; Faculty; Florida; Formulation; Formulations, Drug; Funding; Hearing; Hearing Loss; Hearing Loss, Noise-Induced; History; Human; Human, General; Hypoacuses; Hypoacusis; IACUC; IRBs; Impact, Environmental; Individual; Institutional Animal Care and Use Committee; Institutional Review Boards; International; Intervention; Intervention Strategies; Investigators; Ischemia; Literature; Man (Taxonomy); Man, Modern; Measurement; Medical; Medical center; Medication; Micronutrients; Monitor; Multimodal Therapy; Multimodal Treatment; Multimodality Treatment; Music; Musics; N-Methyl-D-Aspartate Receptors; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDA receptor antagonist; Noise; Noise-Induced Hearing Loss; Oto/Rhino/Laryngology; Otolaryngology; Ph.D.; PhD; Pharmaceutic Preparations; Pharmaceutical Preparations; Play; Population; Position; Positioning Attribute; Principal Investigator; Procedures; Programs (PT); Programs [Publication Type]; Published Comment; Publishing; Receptors, N-Methylaspartate; Recording of previous events; Reflex; Reflex action; Research; Research Design; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Role; Site; Spain; Speech; Structure of tensor tympani muscle; Study Type; Supervision; Sweden; Tensor Tympani; Testing; Toxic effect; Toxicities; Treatment Side Effects; Tympanus, Tensor; Universities; Vasodilatation; Vasodilation; Vasorelaxation; Vertebrate Animals; Vertebrates; Viewpoint; Viewpoint (PT); Work; abstracting; acoustic reflex; animal data; anti-oxidant; base; clinical effect; clinical investigation; clinical test; combination therapy; combined modality treatment; combined treatment; cost; design; designing; drug/agent; expectation; expiration; hearing impairment; hearing perception; human subject; interest; interventional strategy; multimodality therapy; musician; novel; otorhinolaryngology; professor; programs; research clinical testing; response; side effect; social role; sound perception; study design; tensor tympani muscle; therapy adverse effect; treatment adverse effect; vertebrata",Micronutrient intervention to reduce noise-induced hearing loss,,8423,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,3,711176,
7769514,U01,DK,5,,01/01/2010,12/31/2010,,5U01DK056943-10,,NIDDK:289974;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,KANSAS CITY,UNITED STATES,INTERNAL MEDICINE/MEDICINE,03,016060860,US,KS,66160,UNIVERSITY OF KANSAS MEDICAL CENTER,"GRANTHAM, JARED JAMES;",1873378;,5U01DK056943,02/01/2000,12/31/2010,"ADPKD; Adult Polycystic Kidney Disease; Affect; Age; Alabama; Albuminuria; Autosomal Dominant Polycystic Kidney; Bears; Blood Pressure; Blood Pressure, High; CRISP; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Cyst; Cystic kidney; DNA; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deoxyribonucleic Acid; Disease Progression; Dominant Polycystic Kidney Disease; ESRD; End stage renal failure; End-Stage Kidney Disease; Event; Excretory function; Family member; Flow, Renal Blood; Future; Generalized Growth; Genetic; Genotype; Goals; Growth; Hematuria; Hepatic; Hour; Hypertension; Imaging Procedures; Imaging Techniques; Individual; Intervention; Intervention Strategies; Investigation; Investigators; Kansas; Kidney; Kidney Calculi; Kidney Cyst; Kidney Failure; Kidney Insufficiency; Kidney Stones; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metric; Modeling; Monitor; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Pain; Painful; Participant; Phenotype; Polycystic Kidney; Polycystic Kidney Disease, Autosomal Dominant; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; Programs (PT); Programs [Publication Type]; Renal Blood Flow; Renal Calculi; Renal Cyst; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal Stone; Renal function; Renin-Angiotensin-Aldosterone System; Reproducibility; Research Personnel; Researchers; Sampling; Small Inducible Cytokine A2; System, Renin-Angiotensin-Aldosterone; Technics, Imaging; Technology; Testing; Time; Tissue Growth; UTI; Universities; Urinary System, Kidney; Urinary tract infection; Urinary tract infectious disease; Ursidae; Ursidae Family; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Washington; Zeugmatography; biomarker; clinical data repository; clinical data warehouse; clinical investigation; data repository; excretion; hyperpiesia; hyperpiesis; hypertensive disease; interventional strategy; kidney function; kidney imaging; nephrolith; ontogeny; primary outcome; programs; relational database; renal; sex; urinary",Kansas Polycystic Kidney Imaging Program (CRISPII),,56943,ZDK1,Special Emphasis Panel,,10,289974,
7762853,U01,DK,5,,01/01/2010,12/31/2010,DK-05-501,5U01DK056956-10,,NIDDK:313329;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ATLANTA,UNITED STATES,INTERNAL MEDICINE/MEDICINE,05,066469933,US,GA,30322,EMORY UNIVERSITY,"CHAPMAN, ARLENE B;",2453584;,5U01DK056956,02/01/2000,12/31/2010,"ADPKD; Adult Polycystic Kidney Disease; Affect; Age; Alabama; Albuminuria; Aldosterone; Angiotensin-Forming Enzyme; Angiotensinogenase; Autosomal Dominant Polycystic Kidney; Bears; Blood Plasma; Blood Pressure; Blood Pressure, High; CRISP; Clinic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Cyst; Cystic kidney; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease Progression; Dominant Polycystic Kidney Disease; ESRD; End stage renal failure; End-Stage Kidney Disease; Event; Excretory function; Family member; Flow, Renal Blood; Future; Generalized Growth; Genetic; Genotype; Goals; Growth; Hematuria; Hepatic; Hour; Hypertension; Imaging Procedures; Imaging Techniques; Individual; Intervention; Intervention Strategies; Investigation; Investigators; Kansas; Kidney; Kidney Calculi; Kidney Cyst; Kidney Failure; Kidney Insufficiency; Kidney Stones; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metric; Modeling; Monitor; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Pain; Painful; Participant; Phenotype; Plasma; Polycystic Kidney; Polycystic Kidney Disease, Autosomal Dominant; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-; Renal Blood Flow; Renal Calculi; Renal Cyst; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal Stone; Renal function; Renin; Renin-Angiotensin-Aldosterone System; Reproducibility; Research Personnel; Researchers; Reticuloendothelial System, Serum, Plasma; Sampling; Serum, Plasma; Severity of illness; Small Inducible Cytokine A2; System, Renin-Angiotensin-Aldosterone; Technics, Imaging; Technology; Testing; Time; Tissue Growth; UTI; Universities; Urinary System, Kidney; Urinary tract infection; Urinary tract infectious disease; Ursidae; Ursidae Family; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Washington; Zeugmatography; clinical data repository; clinical data warehouse; clinical investigation; data repository; disease severity; excretion; hyperpiesia; hyperpiesis; hypertensive disease; interventional strategy; kidney function; nephrolith; ontogeny; primary outcome; relational database; renal; sex; urinary","""The Early Collaborative Clinical Studies in PKD: The C*",,56956,ZDK1,Special Emphasis Panel,,10,313329,
7769540,U01,DK,5,,01/01/2010,12/31/2010,DK-05-501,5U01DK056957-10,,NIDDK:334788;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","TORRES, VICENTE E;",1881254;,5U01DK056957,02/01/2000,12/31/2010,"ADPKD; Adult Polycystic Kidney Disease; Affect; Age; Alabama; Albuminuria; Autosomal Dominant Polycystic Kidney; Bears; Blood Pressure; Blood Pressure, High; CRISP; Characteristics; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Cyst; Cystic kidney; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease Progression; Dominant Polycystic Kidney Disease; ESRD; End stage renal failure; End-Stage Kidney Disease; Event; Excretory function; Family member; Flow, Renal Blood; Future; Generalized Growth; Genetic; Genotype; Goals; Growth; Hematuria; Hepatic; Hour; Hypertension; Image; Imaging Procedures; Imaging Techniques; Individual; Intervention; Intervention Strategies; Investigation; Investigators; Kansas; Kidney; Kidney Calculi; Kidney Cyst; Kidney Failure; Kidney Insufficiency; Kidney Stones; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metric; Monitor; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Pain; Painful; Participant; Pattern; Phenotype; Polycystic Kidney; Polycystic Kidney Disease, Autosomal Dominant; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; Renal Blood Flow; Renal Calculi; Renal Cyst; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal Stone; Renal function; Renin-Angiotensin-Aldosterone System; Reproducibility; Research Personnel; Researchers; Sampling; Severity of illness; Small Inducible Cytokine A2; System, Renin-Angiotensin-Aldosterone; Technics, Imaging; Technology; Testing; Time; Tissue Growth; UTI; Universities; Urinary System, Kidney; Urinary tract infection; Urinary tract infectious disease; Ursidae; Ursidae Family; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Washington; Zeugmatography; clinical data repository; clinical data warehouse; clinical investigation; data repository; disease severity; excretion; hyperpiesia; hyperpiesis; hypertensive disease; imaging; innovate; innovation; innovative; interventional strategy; kidney function; nephrolith; ontogeny; primary outcome; relational database; renal; sex; urinary",Polycystic Kidney Disease: Innovative Imaging to Assess Progression (PCC),,56957,ZDK1,Special Emphasis Panel,,10,334788,
7762855,U01,DK,5,,01/01/2010,12/31/2010,DK-05-501,5U01DK056961-11,,NIDDK:513151;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,PITTSBURGH,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,14,004514360,US,PA,15213,UNIVERSITY OF PITTSBURGH AT PITTSBURGH,"BAE, KYONGTAE T;",6667397;,5U01DK056961,09/30/1999,12/31/2010,"ADPKD; Adult Polycystic Kidney Disease; Affect; Age; Alabama; Albuminuria; Autosomal Dominant Polycystic Kidney; Bears; Blood Pressure; Blood Pressure, High; CRISP; Characteristics; Clinic; Clinical; Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Cyst; Cystic kidney; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Disease Progression; Dominant Polycystic Kidney Disease; ESRD; End stage renal failure; End-Stage Kidney Disease; Event; Excretory function; Family member; Flow, Renal Blood; Future; Generalized Growth; Genetic; Genotype; Goals; Growth; Hematuria; Hepatic; Hour; Hypertension; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; Individual; Intervention; Intervention Strategies; Investigation; Investigators; Kansas; Kidney; Kidney Calculi; Kidney Cyst; Kidney Failure; Kidney Insufficiency; Kidney Stones; Life; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Measurement; Measures; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Metric; Monitor; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Factor; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Morbidity; Morbidity - disease rate; NMR Imaging; NMR Tomography; Nuclear Magnetic Resonance Imaging; Pain; Painful; Participant; Pattern; Phenotype; Polycystic Kidney; Polycystic Kidney Disease, Autosomal Dominant; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; ROC Analysis; Renal Blood Flow; Renal Calculi; Renal Cyst; Renal Disease, End-Stage; Renal Failure; Renal Insufficiency; Renal Stone; Renal function; Renin-Angiotensin-Aldosterone System; Reproducibility; Research Personnel; Researchers; Sampling; Severity of illness; Small Inducible Cytokine A2; System, Renin-Angiotensin-Aldosterone; Technics, Imaging; Technology; Testing; Time; Tissue Growth; UTI; Universities; Urinary System, Kidney; Urinary tract infection; Urinary tract infectious disease; Ursidae; Ursidae Family; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Washington; Zeugmatography; clinical data repository; clinical data warehouse; clinical investigation; data repository; disease severity; excretion; hyperpiesia; hyperpiesis; hypertensive disease; image evaluation; interventional strategy; kidney function; nephrolith; ontogeny; primary outcome; relational database; renal; sex; urinary",Data Coordinating and Image Analysis for CRISP-II,,56961,ZDK1,Special Emphasis Panel,,11,513151,
7766233,U01,GM,5,,02/01/2010,01/31/2011,GM-05-011,5U01GM076426-05,,NIGMS:259027;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,PHILADELPHIA,UNITED STATES,OTHER CLINICAL SCIENCES,02,042250712,US,PA,19104,UNIVERSITY OF PENNSYLVANIA,"SMITH, GARY ;",1974061;,5U01GM076426,02/01/2006,01/31/2011,"Accounting; Adulterated Food; Adverse effects; Animals; Au element; Aves; Avian; Avian Influenza; Behavior; Bird Flu; Birds; Bovine Species; Businesses; Cattle; Code; Coding System; Commerce; Commerces; County; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Deer; Disease; Disease model; Disorder; Domestic Fowls; Economics; Epidemic; Family; Family suidae; Farm; Farm Animal; Farming environment; Foot-and-Mouth Disease; Force of Gravity; Fowl Pest; Fowl Plague; Fowls, Domestic; Gold; Gravities; Heterogeneity; Human; Human, General; Individual; Infection; Infection Control; Influenza, Avian; Literature; Livestock; Livestocks; Location; Man (Taxonomy); Man, Modern; Maps; Measures; Method LOINC Axis 6; Methodology; Methods; Modeling; Movement; Outcome; Ovis; Pattern; Pennsylvania; Pigs; Population; Poultry; Prevention; Prevention program; Prevention strategy; Preventive strategy; Quarantine; Recovery; Resolution; Sheep; Social Well-Being; Speed; Speed (motion); Suidae; Swine; System; System, LOINC Axis 4; Testing; Therapy, Vaccine; Treatment Side Effects; VAC-TX; Vaccination; Vaccine Therapy; Work; agroterrorism; avian flu; base; body movement; bovid; bovine; clinical data repository; clinical data warehouse; comparative; cow; data repository; deliberate food contamination; deliberate food tampering; density; disease control; disease/disorder; disorder control; disorder model; evidence base; feral; food terrorism; influenza in birds; instrument; intentional food contamination; intentional food tampering; intentionally adulterated food; interest; isolation/quarantine; porcine; relational database; response; side effect; social; success; suid; therapy adverse effect; tool; treatment adverse effect",Hierarchical models for the spatio-temporal dynamics in*,,76426,ZGM1,Special Emphasis Panel,,5,259027,
7766237,U01,GM,5,,02/01/2010,01/31/2011,GM-05-011,5U01GM076499-05,,NIGMS:293193;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,IRVINE,UNITED STATES,BIOLOGY,48,046705849,US,CA,926977600,UNIVERSITY OF CALIFORNIA IRVINE,"BUSH, ROBIN M.;",1923171;,5U01GM076499,02/01/2006,01/31/2011,"Archives; Aves; Avian; Base Sequence; Birds; CDC; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Charge; Computer Simulation; Computerized Models; Computing Methodologies; Data; Epidemic; Evolution; Future; Grippe; Homology Modeling; Human; Human, General; Immunity; Influenza; Investigators; Man (Taxonomy); Man, Modern; Mathematical Model Simulation; Mathematical Models and Simulations; Mediating; Methods; Modeling; Models, Computer; Molecular; Nucleotide Sequence; Pattern; Population; Population Dynamics; Process; Programs (PT); Programs [Publication Type]; Relative; Relative (related person); Research; Research Personnel; Researchers; Risk; Robin; Robin bird; Sampling; Screening procedure; Simulation, Computer based; Sorting - Cell Movement; Testing; Time; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; Vaccinated; Vaccination; Vaccine Design; Vaccines; Viral; Virus; Viruses, General; Work; Zoonoses; base; computational chemistry; computational methodology; computational methods; computational modeling; computational models; computational simulation; computer based models; computer based prediction; computer methods; computerized modeling; computerized simulation; cross immunity; cross reactivity; design; designing; flu infection; flu outbreak; improved; in silico; influenza infection; influenza outbreak; model development; molecular shape; nucleic acid sequence; pandemic; pandemic disease; pathogen; predictive modeling; programs; screening; screenings; sorting; success; surveillance data; vaccination strategy; vaccine efficacy; virtual simulation",Computational Models of Pathogen Evolution and Vaccinat*,,76499,ZGM1,Special Emphasis Panel,,5,293193,
7762709,U01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5U01HL089645-02,,NHLBI:264425;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","ROBB, RICHARD A;",1961924;,5U01HL089645,02/01/2009,01/31/2015,"Ablation; Accessory Sinuses; After Care; After-Treatment; Aftercare; Age; Age-Years; Algorithms; Anti-Arrhythmia Agents; Anti-Arrhythmia Drugs; Anti-Arrhythmics; Antiarrhythmia Agents; Antiarrhythmia Drugs; Antiarrhythmic Drugs; Apoplexy; Arm; Arrhythmia; Arts; Asystole; Atrial; Atrial Fibrillation; Atrial Function; Atrium, Left; Auricle of Heart; Auricular Fibrillation; Bleeding; Body Tissues; Caliber; Cardiac Arrest; Cardiac Arrhythmia; Cardiac Atrium; Cardiac Diseases; Cardiac Disorders; Cardiac Surgery; Cardiac Surgery procedures; Cardiac Surgical Procedures; Cardiac ablation; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Catheter Ablation; Catheters; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Chest; Cicatrix; Clinical Trials; Clinical Trials, Unspecified; Communication; Computer Programs; Computer software; Constriction, Pathologic; Constriction, Pathological; Data Coordinating Center; Data Coordination Center; Diameter; Drug Controls; Drug Therapy; Drugs; Dysfunction; EFRAC; ELIG; Ejection Fraction; Eligibility; Eligibility Determination; Esophageal injury; Esophagus; FLR; Failure (biologic function); Functional disorder; Gastrointestinal Tract, Esophagus; Goals; Graphical interface; Health Care Costs; Health Costs; Health Policy; Healthcare; Healthcare Costs; Heart Arrest; Heart Arrhythmias; Heart Atrium; Heart Diseases; Hemorrhage; Holter Electrocardiography; Holtmon; Image; Image Analyses; Image Analysis; Incidence; Injury to Esophagus; Investigation; Investigators; Left; Left Atrium of Heart; Left atrial structure; Link; Living Costs; Measurement; Measures; Medical; Medication; Methods; Methods and Techniques; Methods, Other; Monitor; Monitoring, Holter; Morbidity; Morbidity - disease rate; Morphology; Mortality; Mortality Vital Statistics; Myocardial; Nasal Sinuses; Nasal cavity/Paranasal; Nasal cavity/Paranasal sinuses; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; Pace Stimulators; Pacemakers; Paranasal Sinuses; Patients; Performance; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Pharmacotherapy; Phase; Physiopathology; Prevalence; Process; Protocol; Protocol Screening; Protocols documentation; Public Health; Pulmonary veins; QOL; Quality of life; ROC Analysis; Radiofrequency Catheter Ablation; Randomized; Recurrence; Recurrent; Relative; Relative (related person); Reporting; Research Personnel; Researchers; Risk; Risk Factors; Role; Scanning; Scars; Shapes; Sinus; Software; Stenosis; Stimulators, Electrical, Pace; Stroke; Structure; Surgical; Surgical Interventions; Surgical Procedure; Surgical Procedures, Heart; Symptoms; System; System, LOINC Axis 4; Techniques; Testing; Thorace; Thoracic; Thorax; Tissues; Upper arm; Validation; Variant; Variation; Vascular Accident, Brain; Vascular, Heart; aging population; antiarrhythmic agent; arrhythmic agent; atrium; base; blood loss; brain attack; cerebral vascular accident; circulatory system; clinical investigation; computer program/software; cost; cost effectiveness; drug/agent; evidence base; failure; graphic user interface; graphical user interface; health care policy; heart disorder; heart surgery; image evaluation; imaging; improved; insight; interest; minimally invasive; modifiable risk; pathophysiology; public health medicine (field); randomisation; randomization; randomly assigned; response; social role; stroke; surgery; treatment effect; treatment strategy",Cabana Image Analysis Lab," PROJECT NARRATIVE The rapidly increasing incidence of cardiac arrhythmias, and particularly atrial fibrillation (AF), in an aging population has become a major public health problem. Current prevalent treatments for atrial fibrillation are medication (pharmaceuticals), pacemakers, catheter-based myocardial ablation, and open chest heart surgery. Pacemakers are ineffective in many patients, especially those with AF, and due to the risk and morbidity of surgery, the potential for effective, less invasive treatments has become of high interest. However, no compelling quantitative comparison of performance and outcomes for pharmaceutical versus ablative treatment has been accomplished. This proposal, one of four linked in a synergistic coalition to conduct a large clinical trial, will provide exactly the quantitative measures required to settle the issue and produce a ""winner"". That method will become the compelling first choice for effective minimally invasive treatment for millions of people who have serious atrial fibrillation.",89645,ZHL1,Special Emphasis Panel,,2,264425,
7762707,U01,HL,5,,02/01/2010,01/31/2011,PA-07-070,5U01HL089907-02,,NHLBI:222470;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,DURHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,04,044387793,US,NC,27705,DUKE UNIVERSITY,"MARK, DANIEL B;",1888432;,5U01HL089907,02/01/2009,01/31/2015,"Ablation; Absenteeism; Accessory Sinuses; Active Follow-up; Age; Age-Years; Anti-Arrhythmia Agents; Anti-Arrhythmia Drugs; Anti-Arrhythmics; Antiarrhythmia Agents; Antiarrhythmia Drugs; Antiarrhythmic Drugs; Apoplexy; Arm; Arts; Asystole; Atrial; Atrial Fibrillation; Auricle of Heart; Auricular Fibrillation; Bleeding; Cardiac Arrest; Cardiac Atrium; Cardiac Diseases; Cardiac Disorders; Cardiac ablation; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Care, Health; Catheter Ablation; Catheters; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Characteristics; Clinical; Comment; Comment (PT); Comment [Publication Type]; Commentary; Commentary (PT); Companions; Data; Drug Controls; Drug Therapy; Drugs; ELIG; Economic Policy; Economics; Editorial Comment; Editorial Comment (PT); Eligibility; Eligibility Determination; Enrollment; FLR; Failure (biologic function); Goals; Health Care Costs; Health Costs; Health Policy; Healthcare; Healthcare Costs; Heart Arrest; Heart Atrium; Heart Diseases; Hemorrhage; Holter Electrocardiography; Holtmon; Image; Image Analyses; Image Analysis; Investigators; Laboratories; Left; Life; Life Expectancy; Living Costs; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Medical; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medication; Methods; Monitor; Monitoring, Holter; Morbidity; Morbidity - disease rate; Morphology; Mortality; Mortality Vital Statistics; Multicenter Trials; NMR Imaging; NMR Tomography; Nasal Sinuses; Nasal cavity/Paranasal; Nasal cavity/Paranasal sinuses; Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Paranasal Sinuses; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacotherapy; Pilot Projects; Policy, Economic; Productivity; Protocol Screening; Published Comment; QOL; Quality of life; Quality-Adjusted Life Years; ROC Analysis; Radiofrequency Catheter Ablation; Randomized; Randomized Clinical Trials; Recurrence; Recurrent; Relative; Relative (related person); Research Personnel; Researchers; Risk Factors; Role; Shapes; Sinus; Stroke; Suggestion; Surgical; Surgical Interventions; Surgical Procedure; Symptoms; TXT; Testing; Text; Time; Trials, Randomized Clinical; Uncertainty; Upper arm; Validation; Vascular Accident, Brain; Vascular, Heart; Viewpoint; Viewpoint (PT); Work; Zeugmatography; antiarrhythmic agent; arrhythmic agent; atrium; base; blood loss; brain attack; cardiac rhythm; cerebral vascular accident; circulatory system; cost; cost effectiveness; doubt; drug standard; drug/agent; enroll; evidence base; failure; follow-up; health care policy; health related quality of life; heart disorder; heart rhythm; image evaluation; imaging; interest; modifiable risk; pilot study; policy implication; productivity loss; prospective; randomisation; randomization; randomly assigned; response; social role; stroke; surgery; treatment effect; treatment strategy; trial comparing",CABANA EQOL Trial," This project is a randomized clinical trial comparing two methods of treating atrial fibrillation, a common and serious type of heart rhythm abnormality with a catheter based treatment versus standard drug treatment to evaluate which one is associated with longer life expectancy. This part of the project will examine the cost and quality of life consequences of these two treatments.",89907,ZHL1,Special Emphasis Panel,,2,222470,
7806619,U01,MH,5,,01/01/2010,12/31/2010,PA-01-123,5U01MH070009-05,,NIMH:170280;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,BOSTON,UNITED STATES,,09,073130411,US,MA,02199,MASSACHUSETTS GENERAL HOSPITAL,"GOFF, DONALD C.;",1891221;,5U01MH070009,02/01/2006,12/31/2010,"4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; Accident and Emergency department; Address; Adherence; Adherence (attribute); Adverse effects; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Bed Occupancy; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical Research; Clinical Study; Consent; Country; D-Glucose; Data; Day Care; Development; Dextrose; Drugs; Effectiveness; Emergency Department; Emergency room; Generations; Glucose; HOSP; Health Benefit; History; Hospitalization, Partial; Hospitals; Injectable; Intervention; Intervention Strategies; LTH; Lactogenic Hormone, Pituitary; Major Tranquilizers; Mammotropic Hormone, Pituitary; Mammotropin; Masks; Measures; Medication; Metabolic; Microbeads; Microspheres; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Oral; PRL; PRL (Prolactin); Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physicians; Prevention of relapse; Programs (PT); Programs [Publication Type]; Prolactin; Protocol; Protocols documentation; Psychopathology; Public Health; QOL; Quality of life; Randomized; Recording of previous events; Recruitment Activity; Regimen; Relapse; Relative; Relative (related person); Rest; Risperidone; Safety; Schizophrenia; Schizophrenic Disorders; Self Administration; Site; Stigmata; Symptoms; Time; Tranquilizing Agents, Major; Translating; Translatings; Treatment Day Care; Treatment Side Effects; Triacylglycerol; Triglycerides; United States; Visit; Weight Gain; Weight Increase; abnormal psychology; atypical antipsychotic; bed days; blind; body weight gain; body weight increase; dementia praecox; design; designing; discontinuation study; discontinuation trial; disorder later incidence prevention; drug/agent; effectiveness trial; experience; innovate; innovation; innovative; intervention design; interventional strategy; language translation; luteotropic hormone; luteotropin; non-compliance; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; psychoeducational intervention; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; recruit; resperidone; response; schizophrenic; service utilization; side effect; social stigma; stigma; therapy adverse effect; therapy design; treatment adherence; treatment adverse effect; treatment design; wt gain",Relapse Prevention: Long-Acting Atypical Antipsychotics,,70009,ZMH1,Special Emphasis Panel,,5,170280,
7762162,U01,MH,5,,01/01/2010,12/31/2010,PA-01-123,5U01MH070011-05,,NIMH:440542;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,AUGUSTA,UNITED STATES,PSYCHIATRY,12,966668691,US,GA,30912,MEDICAL COLLEGE OF GEORGIA (MCG),"BUCKLEY, PETER F;",2298269;,5U01MH070011,02/27/2006,12/31/2010,"4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; Accident and Emergency department; Address; Adherence; Adherence (attribute); Adverse effects; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Bed Occupancy; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical Research; Clinical Study; Consent; Country; D-Glucose; Data; Day Care; Development; Dextrose; Drugs; Effectiveness; Emergency Department; Emergency room; Generations; Glucose; HOSP; Health Benefit; History; Hospitalization, Partial; Hospitals; Injectable; Intervention; Intervention Strategies; LTH; Lactogenic Hormone, Pituitary; Major Tranquilizers; Mammotropic Hormone, Pituitary; Mammotropin; Masks; Measures; Medication; Metabolic; Microbeads; Microspheres; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Oral; Outcome; PRL; PRL (Prolactin); Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physicians; Prevention of relapse; Programs (PT); Programs [Publication Type]; Prolactin; Protocol; Protocols documentation; Psychopathology; Public Health; QOL; Quality of life; Randomized; Recording of previous events; Recruitment Activity; Regimen; Relapse; Relative; Relative (related person); Rest; Risperidone; Safety; Schizophrenia; Schizophrenic Disorders; Self Administration; Site; Stigmata; Symptoms; Time; Tranquilizing Agents, Major; Translating; Translatings; Treatment Day Care; Treatment Side Effects; Triacylglycerol; Triglycerides; United States; Visit; Weight Gain; Weight Increase; abnormal psychology; atypical antipsychotic; bed days; blind; body weight gain; body weight increase; dementia praecox; design; designing; discontinuation study; discontinuation trial; disorder later incidence prevention; drug/agent; effectiveness trial; experience; innovate; innovation; innovative; intervention design; interventional strategy; language translation; luteotropic hormone; luteotropin; non-compliance; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; psychoeducational intervention; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; recruit; resperidone; response; schizophrenic; service utilization; side effect; social stigma; stigma; therapy adverse effect; therapy design; treatment adherence; treatment adverse effect; treatment design; wt gain",Relapse Prevention: Long-Acting Atypical Antipsychotics,,70011,ZMH1,Special Emphasis Panel,,5,440542,
7775053,U01,MH,5,,01/01/2010,12/31/2010,PA-01-123,5U01MH070016-05,,NIMH:201408;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,OMAHA,UNITED STATES,PSYCHIATRY,02,053309332,US,NE,68178,CREIGHTON UNIVERSITY,"WILSON, DANIEL R;",7648322;,5U01MH070016,02/01/2006,12/31/2010,"4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl-; Accident and Emergency department; Address; Adherence; Adherence (attribute); Adverse effects; Antipsychotic Agents; Antipsychotic Drugs; Antipsychotics; Bed Occupancy; Cholest-5-en-3-ol (3beta)-; Cholesterol; Clinical Research; Clinical Study; Consent; Country; D-Glucose; Data; Day Care; Development; Dextrose; Drugs; Effectiveness; Emergency Department; Emergency room; Generations; Glucose; HOSP; Health Benefit; History; Hospitalization, Partial; Hospitals; Injectable; Intervention; Intervention Strategies; LTH; Lactogenic Hormone, Pituitary; Major Tranquilizers; Mammotropic Hormone, Pituitary; Mammotropin; Masks; Measures; Medication; Metabolic; Microbeads; Microspheres; Neuroleptic Agents; Neuroleptic Drugs; Neuroleptics; Oral; Outcome; PRL; PRL (Prolactin); Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Physicians; Prevention of relapse; Programs (PT); Programs [Publication Type]; Prolactin; Protocol; Protocols documentation; Psychopathology; Public Health; QOL; Quality of life; Randomized; Recording of previous events; Recruitment Activity; Regimen; Relapse; Relative; Relative (related person); Rest; Risperidone; Safety; Schizophrenia; Schizophrenic Disorders; Self Administration; Site; Stigmata; Symptoms; Time; Tranquilizing Agents, Major; Translating; Translatings; Treatment Day Care; Treatment Side Effects; Triacylglycerol; Triglycerides; United States; Visit; Weight Gain; Weight Increase; abnormal psychology; atypical antipsychotic; bed days; blind; body weight gain; body weight increase; dementia praecox; design; designing; discontinuation study; discontinuation trial; disorder later incidence prevention; drug/agent; experience; innovate; innovation; innovative; intervention design; interventional strategy; language translation; luteotropic hormone; luteotropin; non-compliance; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; psychoeducational intervention; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; recruit; resperidone; response; schizophrenic; service utilization; side effect; social stigma; stigma; therapy adverse effect; therapy design; treatment adherence; treatment adverse effect; treatment design; wt gain",Relapse Prevention: Long-Acting Atypical Antipsychotics,,70016,ZMH1,Special Emphasis Panel,,5,201408,
7752848,U01,NS,5,,12/01/2009,11/30/2010,NS-01-012,5U01NS043127-10,,NINDS:549981;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,HOUSTON,UNITED STATES,NONE,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"TILLEY, BARBARA C;",1864664;,5U01NS043127,09/30/2001,11/30/2011,"Analysis, Data; Chicago; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials, Unspecified; Collaborations; Data; Data Analyses; Data Banks; Data Bases; Data Monitoring Committees; Data Quality; Data and Safety Monitoring Boards; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Ensure; Idiopathic Parkinson Disease; Institutes; Journals; Lewy Body Parkinson Disease; Magazine; Medical; Medical center; Monitor; National Institute of Neurological Disorders and Stroke; Neuroprotectants; Neuroprotective Agents; Neuroprotective Drugs; Outcome Measure; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson's; Parkinson's disease; Parkinsons disease; Participant; Patients; Peer Review; Pilot Projects; Presbyterian Church; Presbyterians; Primary Parkinsonism; Procedures; Protocol; Protocols documentation; Publications; Quality Control; Quality, Data; Reporting; Research Design; Safety; Safety Monitoring Boards; Scientific Publication; Solutions; South Carolina; Study Type; Technology; Universities; adjudication; adjudicative process and procedure; clinical data repository; clinical data warehouse; clinical investigation; data repository; design; designing; neuroprotection; pilot study; randomized trial; relational database; statistical center; study design",Parkinson's Disease Clinical Trial: Statistical Center,,43127,ZNS1,Special Emphasis Panel,,10,549981,
7677330,U01,NS,5,,01/01/2010,12/31/2010,PAR-05-158,5U01NS057496-02,,NINDS:626492;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PALO ALTO,UNITED STATES,,14,624218814,US,CA,943040038,"PALO ALTO INSTITUTE FOR RES & EDU, INC.","WYSS-CORAY, TONY ;",2208848;,5U01NS057496,09/01/2008,12/31/2013,"1-(3-(dimethylamino)propyl)-4-((hydroxyimino)methyl)pyridinium, chloride; 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-; 4-hydroxyiminomethyl-1-(3-N,N-dimethylaminopropyl)pyridinium chloride; Abnormal Assessment of Metabolism; Absorption; Acquired brain injury; Activation, Gene; Age; Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Ammon Horn; Amyloid; Amyloid Substance; Animal growth regulators, transforming growth factors; Assay; Attorneys; Behavioral; Bioassay; Bioavailability; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Bioluminescence; Blood - brain barrier anatomy; Blood-Brain Barrier; Bone-Derived Transforming Growth Factor; Brain; Brain Injuries; Canine Species; Canis familiaris; Cell Communication and Signaling; Cell Culture Techniques; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Characteristics; Chemicals; Chemistry, Pharmaceutical; Chromatography, High Performance Liquid; Chromatography, High Pressure Liquid; Chromatography, High Speed Liquid; Chronic; Clinical Trials; Clinical Trials, Unspecified; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Collaborations; Common Rat Strains; Cornu Ammonis; Counseling; Cytochrome P-450; Cytochrome P-450 Enzyme System; Cytochrome P450; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Digenic Acid; Disturbance in cognition; Dogs; Dose; Drug Interactions; Drug Kinetics; Drugs; Drugs, Investigational; ELIG; Eligibility; Eligibility Determination; Encephalon; Encephalons; Evaluation; FLR; Failure (biologic function); Gene Activation; Genes; Genes, Reporter; Genetic Toxicology; HPLC; Hemato-Encephalic Barrier; High Pressure Liquid Chromatography; Hippocampus; Hippocampus (Brain); Human; Human, General; Hydrogen Oxide; Image; Immune response; Impaired cognition; In Vitro; Injury; Intellectual Property; International; Intracellular Communication and Signaling; Investigational Drugs; Investigational New Drug Application; Investigational New Drugs; Investigators; Kainic Acid; Knowledge; Lawyers; Lead; Legal patent; Libraries; Licensing; Life; Liver; MT-bound tau; Mammals, Dogs; Mammals, Mice; Mammals, Rats; Man (Taxonomy); Man, Modern; Materials Testing; Maximal Tolerated Dose; Maximally Tolerated Dose; Maximum Tolerated Dose; Measures; Medication; Medicinal Chemistry; Metabolic; Metabolic Studies; Metabolism Studies; Mice; Mice, Transgenic; Milk Growth Factor; Modeling; Monitor; Murine; Mus; NOAEL; Nerve Cells; Nerve Degeneration; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocyte; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Neuron Degeneration; Neurons; No-Observed-Adverse-Effect Level; Oral; P450; Patents; Pathogenesis; Pathology; Pathway interactions; Patients; Pb element; Permeability; Pharmaceutic Chemistry; Pharmaceutic Preparations; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacokinetics; Pharmacology; Pharmacology and Toxicology; Phase; Physiologic Availability; Platelet Transforming Growth Factor; Primary Senile Degenerative Dementia; Principal Investigator; Process; Process of absorption; Production; Programs (PT); Programs [Publication Type]; Property; Property, LOINC Axis 2; Protocol Screening; Rat; Rattus; Recombinant Transforming Growth Factor; Reporter; Reporter Genes; Reporting; Research Personnel; Researchers; Route; SCHED; Safety; Schedule; Screening procedure; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Structure; Structure-Activity Relationship; System; System, LOINC Axis 4; TGF B; TGF-beta; TGFbeta; Technology; Testing; Therapeutic; Time; Toxic effect; Toxicities; Toxicogenetics; Toxicokinetics; Toxicology; Toxicology Genetics; Transforming Growth Factor beta; Transforming Growth Factors; Transgenic Mice; Transgenic Organisms; Tumor Growth Factors; Water; absorption; analog; base; bioavailability of drug; biological signal transduction; body system, hepatic; brain damage; brain lesion (from injury); canine; chemical structure function; clinical investigation; cognitive dysfunction; cognitive loss; cognitively impaired; compound 30; compound-1; conditioned fear; cultured cell line; cytokine; dementia of the Alzheimer type; design; designing; domestic dog; drug/agent; effective therapy; efficacy testing; excitotoxicity; experiment; experimental research; experimental study; failure; fear conditioning; heavy metal Pb; heavy metal lead; hippocampal; host response; imaging; immunoresponse; improved; in vitro Assay; in vivo; in vivo Model; injury response; meetings; metabolic abnormality assessment; microtubule associated protein tau; microtubule bound tau; microtubule-associated protein tau; microtubule-bound tau; mouse model; mutant; neural degeneration; neurodegeneration; neurodegenerative illness; neurofibrillary degeneration; neurofibrillary lesion; neurofibrillary pathology; neuron cell death; neuron loss; neuron toxicity; neuronal; neuronal cell death; neuronal degeneration; neuronal loss; neuronal toxicity; neuroprotection; neurotoxicity; neurotrophic factor; neurotrophin; neutrophin; novel; organ system, hepatic; overexpression; pathway; pharmacokinetic characteristic; pre-clinical; preclinical; preclinical safety; preclinical toxicity; prevent; preventing; primary degenerative dementia; programs; receptor expression; research study; response; response to injury; scaffold; scaffolding; scale up; screening; screenings; senile dementia of the Alzheimer type; small molecule; small molecule libraries; structure function relationship; success; tangle; tau; tau Proteins; tau factor; transgenic",Development of an Agonist of the TGF-beta Signaling Pathway to Treat Alzheimer's,,57496,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,2,626492,
8013582,U01,NS,5,,09/01/2009,08/31/2010,,5U01NS057496-02,0001,,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,PALO ALTO,UNITED STATES,,14,624218814,US,CA,943040038,"PALO ALTO INSTITUTE FOR RES & EDU, INC.","WYSS-CORAY, TONY ;",2208848;,5U01NS057496,,,"Agonist; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer's; Alzheimer's Disease; Alzheimers Dementia; Alzheimers disease; Bone-Derived Transforming Growth Factor; Cell Communication and Signaling; Cell Signaling; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Intracellular Communication and Signaling; Milk Growth Factor; Platelet Transforming Growth Factor; Primary Senile Degenerative Dementia; Signal Transduction; Signal Transduction Systems; Signaling; TGF B; TGF-beta; TGFbeta; Transforming Growth Factor beta; biological signal transduction; dementia of the Alzheimer type; primary degenerative dementia; senile dementia of the Alzheimer type",Development of an Agonist of the TGF-beta Signaling Pthway to Treat Alzheimer's,,57496,NSD,National Institute of Neurological Disorders and Stroke Initial Review Group,,2,,626492
7758355,U10,CA,5,,12/01/2009,11/30/2010,,5U10CA011488-40,,NCI:422853;,2010,NATIONAL CANCER INSTITUTE,,BRUSSELS,BELGIUM,,,763839466,BE,,1200,EUROPEAN ORG/RES/TREATMENT/CANCER,"SYLVESTER, RICHARD ;",8725956;,5U10CA011488,12/01/1981,11/30/2010,"Anti-Cancer Agents; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antiproliferative Agents; Antiproliferative Drugs; Applications Grants; Area; Arts; Body Tissues; Cancer Drug; Cancer Patient; Cancer Radiotherapy; Cancer Treatment; Cancer, Oncology; Cancers; Chemotherapeutic Agents, Neoplastic Disease; Clinical; Clinical Research; Clinical Study; Clinical Trial Overviews; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Combination Drug Therapy; Communities; Computers; Congresses; Country; Cytotoxic agent; Cytotoxic drug; Data; Data Pooling; Data Poolings; Development; EORTC; Education; Educational aspects; Educational workshop; Ensure; Europe; European; European Organization for Research and Treatment of Cancer; Faculty; Goals; Grant; Grant Proposals; Grants, Applications; Health Care Professional; Health Professional; Health profession; Healthcare professional; Healthcare worker; Human; Human, General; Iatrogenic Cancer; Individual; International; Interruption; Investigators; Knowledge; Laboratories, Hospital; Laws; Legislation; Link; Logistics; Malignant Neoplasm Therapy; Malignant Neoplasm Treatment; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medical; Meta-Analyses; Meta-Analysis; Method LOINC Axis 6; Methodology; Methods; Modality; Modeling; Mortality; Mortality Vital Statistics; Operation; Operative Procedures; Operative Surgical Procedures; Policies; Polychemotherapy; Procedures; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; QOL; Quality of life; R01 Mechanism; R01 Program; RPG; Radiation therapy; Radiotherapeutics; Radiotherapy; Randomized; Regulation; Regulatory Affairs; Research; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Subjects; Researchers; Safety; Science; Science of Statistics; Scientific Publication; Services; Speed; Speed (motion); Statistics; Statutes and Laws; Surgical; Surgical Interventions; Surgical Procedure; Surrogate End Points; Surrogate Endpoint; Therapeutic; Therapy Related Malignant Neoplasm; Therapy Related Malignant Tumor; Therapy-Associated Cancers; Therapy-Related Cancer; Tissues; Translational Research; Translational Research Enterprise; Translational Science; Treatment outcome; Treatment-Associated Cancer; Treatment-Related Cancer; Tumor Bank; Tumor-Specific Treatment Agents; Work; Workshop; anticancer agent; anticancer drug; anticancer research; anticancer therapy; base; cancer research; cancer therapy; clinical investigation; combination pharmacotherapy; data management; design; designing; hospital laboratories; improved; irradiation; malignancy; member; multidisciplinary; neoplasm/cancer; oncology; programs; prospective; quality assurance; randomisation; randomization; randomly assigned; statistical center; statistics; surgery; translation research enterprise; virtual",EORTC DATA CENTER,,11488,NCI,Subcommittee E - Prevention & Control,,40,422853,
7763780,U10,DD,5,,02/02/2010,02/01/2011,DD-07-001,5U10DD000230-05,,NCBDD:;,2010,CENTERS FOR DISEASE CONTROL AND PREVENTION,,AARHUS,DENMARK,,,309365849,DA,,8000,AARHUS UNIVERSITY HOSPITAL,"KJAERGAARD, SOEREN K;",10224361;,5U10DD000230,05/01/2007,02/01/2012,,Epidemiologic Studies of Reproductive and Developmental Outcomes - Denmark,,230,ZCD1,Special Emphasis Panel,,5,700000,
7754433,U10,EY,5,,01/01/2010,12/31/2010,,5U10EY011751-14,,NEI:6092440;,2010,NATIONAL EYE INSTITUTE,,TAMPA,UNITED STATES,,09,957043193,US,FL,336471642,"JAEB CENTER FOR HEALTH RESEARCH, INC.","KRAKER, RAYMOND ;",9051425;,5U10EY011751,05/01/1997,12/31/2013,"0-11 years old; Adherence; Adherence (attribute); Adverse Experience; Adverse event; Affect; Amblyopia; Analysis, Data; Ancillary Study; Arthritis, Juvenile Chronic; Arthritis, Juvenile Rheumatoid; Budgets; Caring; Certification; Child; Child Youth; Childhood; Children (0-21); Chronic Childhood Arthritis; Clinic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Committee Members; Communication; Communities; Cornea; Cross-Eye; Data; Data Analyses; Data Collection; Development; Electronics; Equipment and supply inventories; Esodeviation; Esotropia; Ethics Committees, Research; Evaluation; Eye; Eye diseases; Eyeball; Funding; Goals; Grant; Human, Child; IRBs; IT Systems; Information Systems; Information Technology Systems; Infrastructure; Institutional Review Boards; Inventory; Investigators; JRA; Manuals; Manuscripts; Measurement; Members, Committee; Method LOINC Axis 6; Methodology; Methods; Minority; Monitor; Myopia; Nasolacrimal Duct; Nasolacrimal duct structure; Nearsightedness; Nearsightednesses; Obstruction; On-Line Systems; Online Systems; Operation; Operative Procedures; Operative Surgical Procedures; Ophthalmologist; Ophthalmology; Optometries; Optometrist; Optometry; Patients; Phorias; Pilot Projects; Play; Population; Preparation; Procedures; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Publications; QOL; Quality Control; Quality of life; Questionnaires; Reporting; Research Ethics Committees; Research Infrastructure; Research Personnel; Researchers; Review Committee; Role; Safety; Scientific Publication; Site; Site Visit; Specific qualifier value; Specified; Squint; Strabismus; Strabismus, Convergent; Strabismus, Internal; Students; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Systems, Data; Testing; Thick; Thickness; Time; Training; Universities; Validation; Visual Acuity; Writing; abstracting; base; children; clinical investigation; clinical research site; clinical site; computerized; corneal; cost; data management; eye disorder; flexibility; instrument; juvenile arthritis; juvenile idiopathic arthritis; near vision; online computer; ophthalmopathy; pediatric; pilot study; programs; quality assurance; routine practice; social role; surgery; web based; web site; youngster",Pediatric Eye Disease Investigator Group Coordinating Center,,11751,ZEY1,Special Emphasis Panel,,14,6092440,
7780365,U10,EY,5,,01/01/2010,12/31/2010,,5U10EY014231-09,,NEI:4500000;NIDDK:1000000;,2010,NATIONAL EYE INSTITUTE,,TAMPA,UNITED STATES,,09,957043193,US,FL,336471642,"JAEB CENTER FOR HEALTH RESEARCH, INC.","GLASSMAN, ADAM ;",10304781;,5U10EY014231,09/30/2002,12/31/2013,"Accountability; Adherence; Adherence (attribute); Adverse Experience; Adverse event; Analysis, Data; Ancillary Study; Blindness; Budgets; Certification; Clinic; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Committee Members; Communication; Contracting Opportunities; Contracts; Data; Data Analyses; Data Collection; Data Set; Dataset; Dedications; Development; Diabetic Retinopathy; Disease; Disorder; Electronics; Ethics Committees, Research; Fellowship; Funding; Goals; Grant; IRBs; Image; Image Analyses; Image Analysis; Impairment; Industry; Institutional Review Boards; Investigation; Investigators; Laboratories; Manuals; Manuscripts; Medical; Members, Committee; Mentors; Method LOINC Axis 6; Methodology; Methods; Minor; Minority; Monitor; Operation; Operative Procedures; Operative Surgical Procedures; Performance; Play; Preparation; Procedures; Programs (PT); Programs [Publication Type]; Progress Reports; Protocol; Protocols documentation; Publications; Quality Control; ROC Analysis; Reading; Reporting; Reports, Progress; Research Ethics Committees; Research Personnel; Researchers; Retina; Retinal; Review Committee; Role; Safety; Scientific Advances and Accomplishments; Scientific Publication; Sight; Site; Site Visit; Specialist; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Time; Training; United States; Universities; Validation; Vision; Visual Acuity; abstracting; base; clinical investigation; clinical research site; clinical site; community based practice; data management; diabetic; disease/disorder; drug distribution; electronic data; flexibility; image evaluation; imaging; macular edema; non-diabetic; nondiabetic; programs; quality assurance; scientific accomplishments; scientific advances; social role; surgery; web site; working group",Diabetic Retinopathy Clinical Research Network Coordinating Center,,14231,ZEY1,Special Emphasis Panel,,9,5500000,
7754377,U10,EY,5,,01/01/2010,12/31/2010,,5U10EY018810-02,,NEI:687998;,2010,NATIONAL EYE INSTITUTE,,ROCHESTER,UNITED STATES,,01,006471700,US,MN,55905,"MAYO CLINIC COLL OF MEDICINE, ROCHESTER","HOLMES, JONATHAN M;",1890612;,5U10EY018810,01/01/2009,12/31/2013,"0-11 years old; Address; Affect; Amblyopia; Applications Grants; Arthritis, Juvenile Chronic; Arthritis, Juvenile Rheumatoid; Caring; Child; Child Youth; Childhood; Children (0-21); Chronic Childhood Arthritis; Clinic; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Communities; Cornea; Cross-Eye; Data; Data Collection; Development; Enrollment; Esodeviation; Esotropia; Exodeviation; Exotropia; Eye; Eye diseases; Eyeball; Fellowship; Funding; Future; Grant; Grant Proposals; Grants, Applications; Human, Child; Infrastructure; Investigators; JRA; Measurement; Mentors; Methods; Myopia; NIH RFA; Nasolacrimal Duct; Nasolacrimal duct structure; Natural History; Nearsightedness; Nearsightednesses; Observational Study; Obstruction; Operation; Operative Procedures; Operative Surgical Procedures; Ophthalmologist; Ophthalmology; Optometries; Optometrist; Optometry; Outcome Measure; Patients; Phorias; Pilot Projects; Prevention; Procedures; Protocol; Protocols documentation; QOL; Quality of life; Randomized Clinical Trials; Request for Applications; Research Infrastructure; Research Personnel; Research Resources; Researchers; Resources; Retinopathy of Prematurity; Retrolental Fibroplasia; Retrolental Fibroplasias; Site; Specific qualifier value; Specified; Squint; Strabismus; Strabismus, Convergent; Strabismus, Divergent; Strabismus, Internal; Structure; Surgical; Surgical Interventions; Surgical Procedure; System; System, LOINC Axis 4; Testing; Thick; Thickness; Time; Training; Trials, Randomized Clinical; Universities; Visual Acuity; base; children; clinical investigation; computerized; corneal; cost; enroll; eye disorder; impression; improved; instrument; juvenile arthritis; juvenile idiopathic arthritis; near vision; ophthalmopathy; pediatric; pilot study; premature retinopathy; prospective; randomized trial; routine practice; surgery; youngster",Pediatric Eye Disease Investigator Group: Chair's Office,,18810,ZEY1,Special Emphasis Panel,,2,687998,
7809464,U10,HD,5,,12/01/2009,11/30/2010,HD-04-023,5U10HD040485-10,,NICHD:292013;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,NEW YORK,UNITED STATES,OBSTETRICS & GYNECOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"WAPNER, RONALD ;",8385906;,5U10HD040485,04/01/2001,03/31/2011,"Aminoacetic Acid; Basic Research; Basic Science; Behavioral; Clinical; Community Hospitals; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Faculty; Genetic Polymorphism; Genotype; Gestation; Glycine; Heterogeneity, Population; Hospitals, Community; Incidence; Infrastructure; Institution; Labor, Premature; NICHD; National Institute of Child Health and Human Development; Nursing Research; Participant; Patients; Perinatal; Perinatal Epidemiology; Polymorphism (Genetics); Polymorphism, Genetic; Population Heterogeneity; Position; Positioning Attribute; Pregnancy; Premature Birth; Premature Labor; Premature Obstetric Labor; Preterm Birth; Preterm Labor; Protocol; Protocols documentation; Receptor Protein; Recruitment Activity; Research; Research Infrastructure; Research Resources; Resources; Services; Site; Specialist; Time; Tocolysis; Tocolytic Agents; Tocolytic Therapy; Tocolytic Treatment; Tocolytics; Universities; Variant; Variation; Woman; clinical data repository; clinical data warehouse; data repository; design; designing; diverse populations; experience; fetal medicine; heterogeneous population; mimetics; polymorphism; premature childbirth; premature delivery; preterm delivery; protocol development; psychosocial; receptor; recruit; relational database; response",NICHD Maternal Fetal Medicine Units Network,,40485,ZHD1,Special Emphasis Panel,,10,292013,
7798157,U10,HD,5,,12/01/2009,11/30/2010,HD-04-023,5U10HD040545-10,,NICHD:267618;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,HOUSTON,UNITED STATES,OBSTETRICS & GYNECOLOGY,07,800771594,US,TX,77225,UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON,"BLACKWELL, SEAN C;",8258811;,5U10HD040545,04/01/2001,03/31/2011,"0-6 weeks old; ACOG; Active Follow-up; Adrenal Cortex Hormones; American College of Obstetricians and Gynecologists; Ancillary Study; Area; BPD; Binding Sites; Birth Weight; Brain; Bronchopulmonary Dysplasia; Characteristics; Cities; Clinical; Clinical Trials; Clinical Trials, Unspecified; Combining Site; Communities; Conduct Clinical Trials; Corticoids; Corticosteroids; County Hospitals; Data; Data Collection; Diabetes Mellitus, Gestational; Diabetes, Gestational; Diabetes, Pregnancy-Induced; Discipline of obstetrics; Encephalon; Encephalons; Enrollment; Enterocolitis, Necrotizing; Equipment; Ethics Committees, Research; Evidence Based Medicine; Extremely Low Birth Weight Infant; Faculty; Fetal Age; Fetal Heart Rate; Fetal Maturity, Chronologic; Fetus; Flooding; Floods; Fostering; General Hospitals; Gestational Age; Gestational Diabetes; Grant; Gynecologic; Gynecology; HOSP; High-Risk Pregnancy; Hospitals; Hospitals, County; Hospitals, General; Human Resources; IRBs; Infant, Extremely Low Birth Weight; Infant, Newborn; Infant, Very Low Birth Weight; Institution; Institutional Review Boards; Intensive Care Units; Investigation; Investigators; Knowledge; Labor, Premature; Laboratory Assistant; Manpower; Medical center; Minority; Monitor; NICHD; National Institute of Child Health and Human Development; Nature; Necrotizing Enterocolitis; Neonatal; Nervous System, Brain; Newborn Infant; Newborns; Nursing Research; Observational Study; Obstetrics; Out-patients; Outpatients; Parents; Patient Recruitments; Patients; Performance; Population; Position; Positioning Attribute; Pregnancy Outcome; Premature Birth; Premature Labor; Premature Obstetric Labor; Preterm Birth; Preterm Labor; Principal Investigator; Productivity; Programs (PT); Programs [Publication Type]; Proteins; Randomized; Randomized Clinical Trials; Reactive Site; Recruitments, Patient; Research; Research Ethics Committees; Research Personnel; Research Resources; Researchers; Resources; Safety; Schools, Medical; Science; Social Support System; Societies; Support System; System; System, LOINC Axis 4; Texas; Therapeutic Corticosteroid; Time; Trials, Randomized Clinical; Universities; Vaginal Birth after Cesarean; Very Low Birth Weight Infant; Woman; Work; chronic lung disease in infants; chronic lung disease in neonatal infants; chronic lung disease in neonates; chronic lung disease in newborns; chronic lung disease in prematurity; clinical investigation; data management; diabetes of pregnancy; enroll; extremely low birth weight; extremely low birthweight; fetal medicine; follow-up; gene product; high risk; infant chronic lung disease; medical schools; member; neonatal chronic lung disease; newborn chronic lung disease; newborn human (0-6 weeks); personnel; population based; premature childbirth; premature delivery; preterm delivery; preterm premature rupture of membranes; programs; racial and ethnic; racial/ethnic; randomisation; randomization; randomly assigned; reproductive; surfactant; very low birth weight infant human",NICHD Maternal Fetal Medicine Units Network,,40545,ZHD1,Special Emphasis Panel,,10,267618,
7681515,U13,DP,5,,09/01/2009,08/31/2010,DP-05-031,5U13DP000618-04,,NCCDPHP:;,2010,NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO,,CALI,COLOMBIA,,,,CO,,,UNIVERSIDAD DEL VALLE,"DE SALAZAR, LIGIA ;",8756102;,5U13DP000618,09/01/2006,08/31/2010,,Workshop-Seminars Program of Evaluation in Health Promotion in Latin America,,618,ZDP1,Special Emphasis Panel,,4,100,
7780442,U13,RR,5,,03/01/2010,02/28/2011,PAR-03-176,5U13RR021994-05,,NCRR:40023;NIBIB:32000;,2010,NATIONAL CENTER FOR RESEARCH RESOURCES,,BALTIMORE,UNITED STATES,,07,155342439,US,MD,21205,HUGO W. MOSER RES INST KENNEDY KRIEGER,"VAN ZIJL, PETER CM;",1866642;,5U13RR021994,03/15/2006,02/28/2011,Address; Biomedical Research; Collaborations; Complex; Emergent Technologies; Emerging Technologies; Focus Groups; Fostering; Funding; Goals; Human Resources; Individual; Institutes; Lectures; Lectures (PT); Lectures [Publication Type]; Manpower; Maps; Maryland; NCRR; NIH; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; National Institutes of Health (U.S.); Posters; Posters [Publication Type]; Principal Investigator; Programs (PT); Programs [Publication Type]; Science; Scientist; Technology; Time; United States National Institutes of Health; lectures; meetings; personnel; posters; programs,Annual Meeting of the NCRR/NIBIB Principal Investigators,,21994,ZRR1,Special Emphasis Panel,,5,72023,
7763809,U19,AI,5,,03/01/2010,02/28/2011,AI-07-002,5U19AI077437-03,,NIAID:1565263;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,PEDIATRICS,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PEDEN, DAVID B;",1990813;,5U19AI077437,03/01/2008,02/28/2013,,Immunobiology of Acute Environmental Asthma,,77437,ZAI1,Special Emphasis Panel,,3,1565263,
8019512,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8451,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TING, JENNY P.Y.;",1886514;,5U19AI077437,,,"21+ years old; A Mouse; APP Secretase; APS Brand of Allopurinol; ATGN; ATP phosphohydrolase; ATPase; Acute; Adenock; Adenosine Triphosphatase; Adenosinetriphosphatase; Adhesion Molecule; Adult; Affect; Allergens; Allo-Puren; Allozym; Allural; Aloprim; Aloral; Alositol; Amyloid Precursor Protein Secretase; Animal Model; Animal Models and Related Studies; Animals; Anoprolin; Antigens; Anzief; Apoptotic; Apulonga; Apurin; Apurol; Aspiration, Respiratory; Asthma; Azupharma Brand of Allopurinol; BASF Brand of Allopurinol; Bacteria; Basic Research; Basic Science; Binding; Binding (Molecular Function); Binding Proteins; Biochemical; Bleminol; Bloxanth; Boehringer Mannheim Brand of Allopurinol; Boots Brand of Allopurinol; Breathing; Bronchial Asthma; Caplenal; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase-1; Cathepsin B1; Cathepsins B; Cell Adhesion Molecules; Cell Line; Cell Lines, Strains; CellLine; Cellidrin; Cells; Characteristics; Childhood; Clinical; Complex; Cosuric; Cytokines, Chemotactic; Dabroson; Data; Disease; Disease Resistance; Disorder; Dorsch Brand of Allopurinol; EC 2.7; EC 3.4.22.1; EC 3.4.22.36; Embarin; Endotoxins; Enzymes; Epidropal; Exhibits; Extravasation; Family; Family member; Foligan; Geapur; Gene Family; Genes; Genes, R; Genes, rap; Genes, vpr; Genomics; Gichtex; Glaxo Wellcome Brand of Allopurinol; Goals; Hamarin; Hennig Brand of Allopurinol; Henning Berlin Brand of Allopurinol; Hexanurat; Homologous Chemotactic Cytokines; Housedust Mites; Human; Human, Adult; Human, General; ICE Protease; IFN-gamma-Inducing Factor; IGIF; IL-1; IL-1 Gamma; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-18; IL-1b Converting Enzyme; IL-1g; IL1; IL18 Protein; IL1B-Convertase; IL1BC; IL1F4; INFLM; Immune; Immune response; Immune system; Immunobiology; Immunoglobulin Enhancer-Binding Protein; Immunologic, Immunochemical; Immunologics; Immunophysiology; In Vitro; Individual; Infection; Inflammation; Inflammatory Response; Inhalation; Inhaling; Inspiration, Respiratory; Intercrines; Interferon-gamma-Inducing Factor; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin I; Interleukin-1; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1 Gamma; Interleukin-18; Interleukin-18 Precursor; Interleukin-1beta Converting Enzyme; K. pneumoniae; Ketanrift; Ketobun-A; Kinases; Klebsiella pneumonia bacterium; Klebsiella pneumoniae; L-Leucine; LRR; Leakage; Ledopur; Leucine; Leucine, L-Isomer; Leucine-Rich Repeat; Ligand Binding Protein; Linkage (Genetics); Lopurin; Lymphocyte-Stimulating Hormone; Lysuron; MEFV gene product; MGC12320; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Merckle Brand of Allopurinol; Mice; Mining; Minings; Miniplanor; Mites, House Dust; Modeling; Molecular Interaction; Monarch; Multipharma Brand of Allopurinol; Murine; Mus; NF-kB; NF-kappa B; NF-kappaB; NFKB; Names; Necrosis; Necrotic; Nektrohan; Nicholas Brand of Allopurinol; Nuclear Factor kappa B; Nuclear Transcription Factor NF-kB; Nucleotides; P45; Pan Quimica; Pathway interactions; Phosphorylation; Phosphotransferases; Plants; Plants, General; Process; Production; Property; Property, LOINC Axis 2; Protein Binding Domain; Protein Binding Motif; Protein Phosphorylation; Protein-Protein Interaction Domain; Proteins; Proteoglycan; Pyroglyphidae; Receptor Protein; Relative; Relative (related person); Remid; Reporting; Resistance, Disease; Rh?'ne-Poulenc Rorer Brand of Allopurinol; Riball; Right-Handed Beta-Alpha Superhelix; Roche Brand of Allopurinol; Role; SIS cytokines; SUBGP; Sampling; Spillage; Sputum; Subgroup; Suspendol; System; System, LOINC Axis 4; T Helper Factor; T-Cells; T-Lymphocyte; TAD Brand of Allopurinol; Takanarumin; Thymus-Dependent Lymphocytes; Transcription Factor NF-kB; Translating; Translatings; Transphosphorylases; Urbol; Uricemil; Uripurinol; Urosin; Urtias; VPR; Walkers; Wellcome Brand of Allopurinol; Work; Xanturat; Zyloprim; Zyloric; adult human (21+); asthmatic patient; body system, allergic/immunologic; cell adhesion protein; chemoattractant cytokine; chemokine; combat; cultured cell line; disease/disorder; drug discovery; dust mite; experiment; experimental research; experimental study; gene product; genetic linkage; gepepharm Brand of Allopurinol; host response; immunogen; immunoresponse; in vivo; inspiration; kappa B Enhancer Binding Protein; language translation; lymphocyte activating factor; macrophage; marenostrin; model organism; novel; nuclear factor kappa beta; organ system, allergic/immunologic; pathogen; pathway; pediatric; pro-caspase-1; procaspase-1; protein function; protein structure; pyrin; pyroglyphid; receptor; reconstitute; reconstitution; research study; resistance to disease; resistant disease; resistant to disease; response; social role; thymus derived lymphocyte; vpr Genes",Novel Innate Immune Genes and Asthma,,77437,ZAI1,Special Emphasis Panel,,3,,314169
8019513,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8455,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"KOLLER, BEVERLY H;",1881083;,5U19AI077437,,,"Abscission; Acute; Animals; Apoptosis; Apoptosis Pathway; Apoptotic; Asthma; Basophilic Histiocyte; Basophils, Tissue; Binding; Binding (Molecular Function); Bronchial Asthma; Caspase 1, Apoptosis-Related Cysteine Protease; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Caspase-1; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Surface Receptors; CellLine; Cells; Complex; Cytoplasmic Protein; Cytosol; Development; Disease; Disorder; EC 3.4.22.36; Endotoxins; Event; Excision; Extirpation; Family; Fungi, Filamentous; Gene Family; Genes; ICE Protease; IFN-gamma-Inducing Factor; IGIF; IL-1; IL-1 Gamma; IL-1 beta Convertase; IL-1 beta-Converting Enzyme; IL-18; IL-1b Converting Enzyme; IL-1g; IL1; IL18 Protein; IL1B-Convertase; IL1BC; IL1F4; Immune response; Immunobiology; Immunophysiology; Inflammatory Response; Interferon-gamma-Inducing Factor; Interleukin 1-B Converting Enzyme; Interleukin 1-Beta Convertase; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin I; Interleukin-1; Interleukin-1 Beta Converting Enzyme; Interleukin-1 Converting Enzyme; Interleukin-1 Gamma; Interleukin-18; Interleukin-18 Precursor; Interleukin-1beta Converting Enzyme; Ion Channel; Ionic Channels; L-Leucine; Lead; Leucine; Leucine, L-Isomer; Lung; Lung Inflammation; Lymphocyte-Stimulating Hormone; MEFV gene product; MGC12320; Macrophage Cell Factor; Mammals, Mice; Marrow Mast Cell; Mediating; Membrane Channels; Mice; Modeling; Molds; Molecular Interaction; Murine; Mus; Necrosis; Necrotic; Nuclear; P45; Pathogenesis; Pathway interactions; Pattern Recognition; Pattern Recognition/Display/Analysis; Pb element; Physiology; Play; Production; Receptor Protein; Receptors, Cell Surface; Recruitment Activity; Removal; Resolution; Respiratory System, Lung; Role; Stimulus; Surgical Removal; T Helper Factor; Testing; allergic airway disease; cultured cell line; cytokine; d-Numb; disease characteristic; disease/disorder; environmental agent; heavy metal Pb; heavy metal lead; host response; immunoresponse; lymphocyte activating factor; macrophage; marenostrin; mast cell; mastocyte; novel; numb protein; pathway; pulmonary; pyrin; receptor; recruit; resection; response; social role",P2X7 and the Inflammasome Pathways in Lung Inflammation,,77437,ZAI1,Special Emphasis Panel,,3,,302409
8019514,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8456,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PEDEN, DAVID B;",1990813;,5U19AI077437,,,"3-10C; AMCF-I; APS Brand of Allopurinol; ATGN; Acidophilic Leukocyte; Acute; Adenock; Adrenal Cortex Hormones; Air; Airway Hyper-responsiveness; Airway Obstruction; Allergens; Allergic; Allergic asthma; Allergic inflammation; Allo-Puren; Allozym; Allural; Aloprim; Aloral; Alositol; Anoprolin; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antigens; Antiinflammatories; Antiinflammatory Agents; Anzief; Apulonga; Apurin; Apurol; Aspiration, Respiratory; Asthma; Azupharma Brand of Allopurinol; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BASF Brand of Allopurinol; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Biological; Biology; Bleminol; Blood Eosinophil; Blood Neutrophil; Blood Polymorphonuclear Neutrophil; Blood Segmented Neutrophil; Blood granulocytic cell; Blood monocyte; Bloxanth; Boehringer Mannheim Brand of Allopurinol; Boots Brand of Allopurinol; Breathing; Bronchial Asthma; Bronchial Constriction; Bronchoconstriction; CD14; CD14 gene; CXCL8; Caplenal; Cell Communication and Signaling; Cell Signaling; Cellidrin; Cells; Closure by Ligation; Corticoids; Corticosteroids; Cosuric; Coupled; Cytofluorometry, Flow; Cytokines, Chemotactic; Dabroson; Data; Dendritic Cells; Deposit; Deposition; Development; Differentiation Factor, B-Cell; Disease; Disorder; Dorsch Brand of Allopurinol; Embarin; Endotoxins; Environmental Irritants; Eosinophilic Granulocyte; Eosinophilic Leukocyte; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epidropal; Epithelial Cells; Event; Exhalation; Exhaling; Expiration, Respiratory; Extrinsic asthma; Face; Family; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Foligan; GCP-1; GCP1; Geapur; Gene Expression; Gene Expression Monitoring; Gene Expression Pattern Analysis; Gene Expression Profiling; Genes; Gichtex; Glaxo Wellcome Brand of Allopurinol; Granular Leukocytes; Granulocytic cell; HPGF; Hamarin; Hennig Brand of Allopurinol; Henning Berlin Brand of Allopurinol; Hepatocyte-Stimulating Factor; Heterophil Granulocyte; Hexanurat; Homologous Chemotactic Cytokines; Human; Human Biology; Human Volunteers; Human, General; Hybridoma Growth Factor; IFN-beta 2; IFN-gamma-Inducing Factor; IFNB2; IGIF; IL-1; IL-1 Gamma; IL-18; IL-1g; IL-6; IL-8; IL1; IL18 Protein; IL1F4; IL6 Protein; IL8; IL8 gene; INFLM; IgE; Immune; Immune response; Immunity; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunobiology; Immunoglobulin E; Immunophysiology; Infection; Inflammation; Inflammatory; Inhalation; Inhaling; Inspiration, Respiratory; Intercrines; Interferon-gamma-Inducing Factor; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18 Proprotein; Interleukin 6 (Interferon, Beta 2); Interleukin I; Interleukin-1; Interleukin-1 Gamma; Interleukin-18; Interleukin-18 Precursor; Interleukin-6; Intracellular Communication and Signaling; K60; Ketanrift; Ketobun-A; Knowledge; LECT; LUCT; LYNAP; Label; Lead; Ledopur; Ligands; Ligation; Liquid substance; Lopurin; Lung; Lymphocyte-Stimulating Hormone; Lysuron; MDNCF; MGC12320; MGI-2; MONAP; Macrophage Cell Factor; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow Eosinophil; Marrow Neutrophil; Marrow monocyte; Measures; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Merckle Brand of Allopurinol; Messenger RNA; Mice; Microfluorometry, Flow; Miniplanor; Mites; Modeling; Modification; Molecular; Monarch; Mucociliary Clearance; Mucociliary Transport; Mucous body substance; Mucus; Multipharma Brand of Allopurinol; Murine; Mus; Myeloid Differentiation-Inducing Protein; NAF; Natural Immunity; Nektrohan; Network Analysis; Neutrophilic Granulocyte; Neutrophilic Leukocyte; Nicholas Brand of Allopurinol; Pan Quimica; Particulate Matter; Pathogenesis; Pathway Analysis; Pathway interactions; Pattern; Pb element; Peripheral; Phase; Physiology; Plasmacytoma Growth Factor; Play; Polymorph; Polymorphonuclear Cell; Polymorphonuclear Leukocytes; Polymorphonuclear Neutrophils; Process; Profilings, Gene Expression; Proteins; Protocol; Protocols documentation; Publishing; Purines; RNA, Messenger; Radiolabeled; Receptor Protein; Regulation; Regulatory Protein; Remid; Reporting; Respiratory System, Lung; Respiratory physiology; Rh?'ne-Poulenc Rorer Brand of Allopurinol; Riball; Risk Factors; Roche Brand of Allopurinol; Role; SCYB8; SIS cytokines; Signal Transduction; Signal Transduction Pathway; Signal Transduction Systems; Signaling; Source; Spirometry; Sputum; Stimulus; Suspendol; T Helper Factor; TAD Brand of Allopurinol; TSG-1; Takanarumin; Testing; Therapeutic Corticosteroid; Transcript Expression Analyses; Transcript Expression Analysis; Urbol; Uricemil; Uripurinol; Urosin; Urtias; Veiled Cells; Volunteers, Human; Wellcome Brand of Allopurinol; Wheezing; Wheezings; Xanturat; Zyloprim; Zyloric; acquired immunity; airway epithelium infalmmation; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway inflammation; airway injury; allergic response; atopic asthma; b-ENAP; biological signal transduction; chemoattractant cytokine; chemokine; cytokine; disease/disorder; environmental endotoxin; environmental particulate; eosinocyte; eosinophil; extrinsic allergic asthma; facial; flow cytophotometry; fluid; gene product; genetic regulatory protein; gepepharm Brand of Allopurinol; granulocyte; heavy metal Pb; heavy metal lead; host response; immunogen; immunoresponse; injured airway; inspiration; interferon beta 2; knowledge translation; liquid; lung function; lymphocyte activating factor; mRNA; macrophage; member; monocyte; mucous; neutrophil; novel; novel therapeutic intervention; particle; pathogen; pathway; pollutant; pulmonary; purine; radiolabel; radiotracer; receptor; regulatory gene product; respiratory function; response; social role; volunteer; wheeze",Airway Biology of Acute Environmental Asthma in Humans,,77437,ZAI1,Special Emphasis Panel,,3,,379351
8019515,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8457,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TING, JENNY P.Y.;",1886514;,5U19AI077437,,,"Acute; Affect; Air Pollutants; Allergens; Allergic; Analysis, Data; Antibodies; Asthma; Award; BRM; Binding; Binding (Molecular Function); Bio-Informatics; Bioinformatics; Biological; Biological Function; Biological Models; Biological Process; Biological Response Modifiers; Biomodulators; Body Tissues; Bronchial Asthma; Cell Death; Cells; Collaborations; Complementary DNA; Computer Programs and Programming; Custom; Cytokines, Chemotactic; DNA, Complementary; Data; Data Analyses; Development; Differential Display; Differential Gene Expression; Disease; Disorder; Displays, mRNA Differential; ESTs; Environmental Pollutants; Equipment; Expressed Sequence Tags; Expression Profiling; Expression Signature; Future; Gene Expression Profile; Gene Targeting; Genes; Goals; Grant; Homologous Chemotactic Cytokines; Human; Human, General; Immune; Immune Mediators; Immune Mediators/Modulators; Immune Regulators; Immunity; Immunobiology; Immunophysiology; Individual; Instrumentation, Other; Intercrines; Investigators; Lung; Mammals, Mice; Man (Taxonomy); Man, Modern; Membrane; Mice; Model System; Models, Biologic; Molecular Fingerprinting; Molecular Interaction; Molecular Profiling; Murine; Mus; Network Analysis; Oxidative Stress; Pathway Analysis; Pathway interactions; Patients; Programs (PT); Programs [Publication Type]; Protein Array; Proteins; Publishing; Pulmonary Body System; Pulmonary Organ System; Research; Research Personnel; Researchers; Respiratory System; Respiratory System, Lung; Respiratory system (all sites); Respiratory tract structure; SIS cytokines; Sampling; Signal Pathway; Slide; Source; System; System, LOINC Axis 4; Systems Biology; Targetings, Gene; Technology; Tissue-Specific Differential Gene Expression; Tissue-Specific Gene Expression; Tissues; Tracts, Respiratory; base; biological adaptation to stress; cDNA; cDNA Arrays; cDNA Microarray; chemoattractant cytokine; chemokine; computer program; computer programming; cytokine; disease/disorder; experiment; experimental research; experimental study; gene expression signature; gene product; instrumentation; mRNA Differential Displays; membrane structure; molecuar profile; molecular signature; mouse model; necrocytosis; novel; pathway; programs; protein profiling; pulmonary; reaction; crisis; representational difference analysis; research study; respiratory tract; response; serial analysis of gene expression; stress response; stress; reaction; transcriptome; user-friendly",Innate Immune Gene Profiling Core,,77437,ZAI1,Special Emphasis Panel,,3,,199976
8019516,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8458,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"TILLEY, STEPHEN LLOYD;",6189697;,5U19AI077437,,,"ATGN; Acute; Airway Hyper-responsiveness; Airway Resistance; Allergens; Allergic; Allergic inflammation; Animal Model; Animal Models and Related Studies; Animals; Antigens; Asthma; Biochemical; Biology; Blood Serum; Body Tissues; Breeding; Bronchial Asthma; Bronchial Lavage Fluid; Cell Count; Cell Number; Chronic; Computers; Data; Development; Disease; Disease model; Disorder; ES cell; Endotoxins; Environmental Pollutants; Eosinophilia; Evaluation; Expertise, Technical; Exposure to; Formalin; Freezing; Genes; Genetic; Goals; Harvest; Histology; Human; Human, General; Immunobiology; Immunophysiology; Individual; Intervention; Intervention Strategies; Investigators; Laboratory mice; Lavage Fluids, Alveolar; Lipids; Lung; Lung Inflammation; Lung Lavage Fluid; Lung Parenchyma; Lung Tissue; Lung diseases; Mammals, Mice; Man (Taxonomy); Man, Modern; Measurable; Measurement; Measures; Mechanics; Messenger RNA; Mice; Mission; Modeling; Mouse Strains; Mucous body substance; Mucus; Murine; Mus; NIAID; National Institute of Allergy and Infectious Disease; Obstruction; Palsy; Paralysed; Pathogenesis; Peripheral; Phase; Phenotype; Physiologic; Physiological; Plegia; Production; Proteins; Protocol; Protocols documentation; Public Health; Pulmonary Diseases; Pulmonary Disorder; RNA, Messenger; Research Personnel; Research Resources; Researchers; Resistance; Resources; Respiratory Disease; Respiratory Disorder; Respiratory System Disease; Respiratory System Disorder; Respiratory System, Lung; Role; Serum; Services; Signal Pathway; Structure of parenchyma of lung; Technical Expertise; Testing; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Tissues; Toxic effect; Toxicities; Transgenic Organisms; Ventilator; Wild Type Mouse; Work; airway epithelium infalmmation; airway hyper-reactivity; airway hyperreactivity; airway hyperresponsiveness; airway inflammation; airway remodeling; design; designing; disease/disorder; disorder model; efficacy testing; embryonic stem cell; environmental agent; gene product; genetic technology; human disease; immunogen; improved; in vivo; interest; interventional strategy; lung disorder; mRNA; meetings; methacholine; model organism; molecular phenotype; mouse model; mucous; novel; paralysis; paralytic; protein expression; public health medicine (field); pulmonary; resistant; response; social role; stem cell of embryonic origin; transgenic",Lung Desease Models Core,,77437,ZAI1,Special Emphasis Panel,,3,,224697
8019517,U19,AI,5,,03/01/2010,02/28/2011,,5U19AI077437-03,8461,,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,CHAPEL HILL,UNITED STATES,,04,608195277,US,NC,27599,UNIVERSITY OF NORTH CAROLINA CHAPEL HILL,"PEDEN, DAVID B;",1990813;,5U19AI077437,,,"Acute; Asthma; Biology; Biostatistics Core; Blood Cells; Bronchial Asthma; Budgets; Clinical Research Protocols; Core Facility; Cytofluorometry, Flow; Development; Environmental Medicine; Ethics Committees, Research; Evaluation; Flow Cytofluorometries; Flow Cytometry; Flow Microfluorimetry; Funding; Head; IRBs; Immunobiology; Immunophysiology; Institutional Review Boards; Liquid substance; Lung; Maryland; Microfluorometry, Flow; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nucleotides; Peripheral Blood Cell; Principal Investigator; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Reporting; Research Ethics Committees; Research Protocols, Clinical; Respiratory System, Lung; SCHED; Sampling; Schedule; Travel; United States National Institutes of Health; animal data; clinical relevance; clinically relevant; data management; flow cytophotometry; fluid; liquid; meetings; programs; protein profiling; protocol development; pulmonary; repository",Administrative Core,,77437,ZAI1,Special Emphasis Panel,,3,,144661
7753142,U24,CA,5,,01/01/2010,12/31/2010,,5U24CA075362-13,,NCI:482375;,2010,NATIONAL CANCER INSTITUTE,,BOSTON,UNITED STATES,,08,076580745,US,MA,02115,DANA-FARBER CANCER INSTITUTE,"GELBER, RICHARD D;",1904157;,5U24CA075362,09/30/1997,12/31/2010,"Active Follow-up; Adjuvant Therapy; Area; Award; Banking, Tissue; Cancer Patient; Cancer of Breast; Characteristics; Clinical; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Development; Diagnosis; Endocrine Therapy; Enrollment; Evaluation; Forecast of outcome; Fostering; Funding; Goals; Grant; Hormonal Therapy; IBCSG; International; International Breast Cancer Study Group; Investigation; Investigators; Link; Maintenance; Maintenances; Malignant Tumor of the Breast; Malignant neoplasm of breast; Medical; Pathogenesis; Pathology; Patients; Prognosis; Programs (PT); Programs [Publication Type]; QOL; Quality of life; Randomized Clinical Trials; Recurrence; Recurrent; Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Time; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Trials, Randomized Clinical; United States; Woman; base; chemotherapy; clinical data repository; clinical data warehouse; clinical investigation; cohort; cytotoxic; data management; data repository; design; designing; enroll; follow-up; hormone therapy; improved; malignant breast neoplasm; outcome forecast; patient population; programs; relational database; response; social role; statistical center; tumor",IBCSG STATISTICAL CENTER--A BREAST CANCER STUDY RESOURCE,,75362,NCI,Subcommittee E - Prevention & Control,,13,482375,
7776863,U24,CA,5,,03/01/2010,02/28/2011,CA-07-004,5U24CA126588-04,,NCI:432762;,2010,NATIONAL CANCER INSTITUTE,,NASHVILLE,UNITED STATES,RADIATION-DIAGNOSTIC/ONCOLOGY,05,004413456,US,TN,372036869,VANDERBILT UNIVERSITY,"GORE, JOHN C;",1894945;,5U24CA126588,05/04/2007,02/28/2012,"Algorithms; Analysis, Data; Animal Cancer Model; AnimalModel; Animals; Arts; Biological; Breast; CAT Scan, X-Ray; CAT scan; CT X Ray; CT scan; Cancer Center; Cancers; Colon or Rectum; Colorectal; Computed Tomography; Computerized Axial Tomography (Computerized Tomography); Computerized Tomography, X-Ray; Computers; Contrast Agent; Contrast Drugs; Contrast Media; Conventional X-Ray; Data Analyses; Data Set; Dataset; Development; Diagnosis, Ultrasound; Diagnostic Radiology; Diagnostic radiologic examination; EMI scan; Echography; Echotomography; Educational workshop; Electronics; Equipment; Evaluation; Faculty; Funding; Gastrointestinal Tract, Pancreas; Genital System, Male, Prostate; Heterograft; Histology; Housing; Human Prostate; Human Prostate Gland; Human Resources; Image; Image Analyses; Image Analysis; Imaging Procedures; Imaging Techniques; Imaging technology; Infrastructure; Instrumentation, Other; Laboratories; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Malignant Neoplasms; Malignant Skin Neoplasm; Malignant Tumor; Malignant Tumor of the Skin; Manpower; Mass Spectrum; Mass Spectrum Analysis; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Medical Imaging, Ultrasound; Medical Imaging, X-Ray; Melanoma and Non-Melanoma Skin Cancer; Methods; Methods and Techniques; Methods, Other; Modality; Molecular; Monitor; NMR Imaging; NMR Tomography; Nuclear; Nuclear Magnetic Resonance Imaging; Optics; Pancreas; Pancreatic; Pathway interactions; Photometry/Spectrum Analysis, Mass; Preparation; Process; Prostate; Prostate Gland; Prostatic Gland; R01 Mechanism; R01 Program; ROC Analysis; RPG; Radiography; Radiology, Diagnostic X-Ray; Radiopaque Media; Research; Research Grants; Research Infrastructure; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Roentgenography; Scientist; Skin Cancer; Skin Cancer, Including Melanoma; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Technics, Imaging; Techniques; Tomodensitometry; Tomography, Xray Computed; Training; Transgenic Organisms; Transplantation, Heterologous; Tumor Biology; Ultrasonic Imaging; Ultrasonogram; Ultrasonography; Ultrasound Test; Ultrasound, Medical; Universities; Workshop; X-Ray Computed Tomography; X-Ray Imaging; X-Ray, Diagnostic; Xenograft; Xenograft procedure; Xenotransplantation; Zeugmatography; cancer imaging; catscan; computed axial tomography; computerized axial tomography; computerized tomography; computing resources; diagnostic ultrasound; image evaluation; image processing; imaging; imaging modality; improved; in vivo; instrument; instrumentation; malignancy; molecular imaging; mouse model; neoplasm/cancer; novel; optic imaging; optical imaging; pathway; personnel; sonogram; sonography; sound measurement; square foot; transgenic; ultrasound; ultrasound imaging; ultrasound scanning",South-Eastern Center for Imaging Animal Models of Cancer,,126588,ZCA1,Special Emphasis Panel,,4,432762,
7806398,U2G,PS,5,,12/15/2009,12/14/2010,PS-07-749,5U2GPS000939-03,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,PHNOM PENH,CAMBODIA,,,,CB,,,NATIONAL INSTITUTE OF PUBLIC HEALTH,"SAVOEUN, NGY ;",9223740;,5U2GPS000939,12/15/2007,12/14/2012,,IMPROVING LABORATORY CAPACITY AND QUALITY FOR HIV/AIDS PROGRAMMING IN THE KINGDOM,,939,ZPS1,Special Emphasis Panel,,3,229000,
7658213,U2G,PS,5,,09/01/2009,08/31/2010,PS-07-724,5U2GPS001084-02,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,WASHINGTON,UNITED STATES,,00,066769738,US,DC,20037,PAN AMERICAN HEALTH ORGANIZATION,"DEL RIEGO, AMALIA ;",9757552;,5U2GPS001084,09/01/2008,08/31/2011,,IMPROVING CAPACITY TO MONITOR THE HIV/AIDS EPIDEMIC IN THE CARIBBEAN,,1084,ZPS1,Special Emphasis Panel,,2,500000,
7806405,U2G,PS,5,,01/15/2010,01/14/2011,PS-07-750,5U2GPS001092-03,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,PHNOM PENH,CAMBODIA,,,,CB,,,NATIONAL CENTER FOR HIV/AIDS/DERMA/STDS,"VUN, MEAN CHHI;",9367532;,5U2GPS001092,01/15/2008,01/14/2013,,EXPANDING HIV/AIDS PROGRAM ACTIVITITES OF THE MINISTRY OF HEALTH OF THE KINGDOM,,1092,ZPS1,Special Emphasis Panel,,3,860000,
7682963,U2G,PS,5,,09/30/2009,09/29/2010,PS-08-810,5U2GPS001134-02,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,GREATER GEORGETOWN,GUYANA,,,,GY,,,CARIBBEAN COMMUNITY (CARICOM),"BROWNE, CARL F;",9473990;,5U2GPS001134,09/30/2008,09/29/2013,,Programme on Coordination and Harmonization of HIV and AIDS activities in the Car,,1134,ZPS1,Special Emphasis Panel,,2,500000,
7753865,U2G,PS,5,,12/15/2009,12/14/2010,PS-08-851,5U2GPS001326-02,,NCHHSTP:;,2010,"NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION",,DAR ES SALAAM,TANZANIA U REP,,,565438611,TZ,,65001,MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS,"KWESIGABO, PAUL ;",9588637;,5U2GPS001326,12/15/2008,12/14/2013,,BUILDING CAPACITY FOR HIV/AIDS HUMAN RESOURCES AT THE MUHIMBILI PUBLIC HEALTH,,1326,ZPS1,Special Emphasis Panel,,2,350000,
7792490,UH1,HL,5,,12/01/2009,11/30/2010,HL-02-012,5UH1HL073461-07,,NHLBI:695800;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ATLANTA,UNITED STATES,,05,102005451,US,GA,30310,MOREHOUSE SCHOOL OF MEDICINE,"DIN-DZIETHAM, REBECCA ;",7047617;,5UH1HL073461,05/15/2003,11/30/2010,"Address; African American; Afro American; Afroamerican; Alabama; American; Area; Arts; Award; Basic Research; Basic Science; Behavioral; Biochemical; Biology; Biomedical Research; Biometrics; Biometry; Biometry and Biostatistics; Biostatistics; Black Populations; Black or African American; Blood Vessels; CDC; COBRE; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Center of Biomedical Research Excellence; Centers for Disease Control; Centers for Disease Control (U.S.); Centers for Disease Control and Prevention; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Clinical Research; Clinical Sciences; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Commit; Communities; Community Health; Complement; Complement Proteins; Cooperative Agreements; Cooperative Agreements, U-Series; Development; Development and Research; Disease; Disorder; Doctor of Philosophy; Education; Educational aspects; Elements; Ensure; Environment; Epidemiologist; Epidemiology; Evaluation; Faculty; Fostering; Future; Gender; Generalized Growth; Genomics; Geographic Area; Geographic Locations; Geographic Region; Geographical Location; Gibbons; Goals; Grant; Growth; Health; Hylobates; Hylobates Genus; Institutes; Institution; Intervention Studies; Investigators; Knowledge; Leadership; Location; M.P.H.; Master of Public Health; MeSH Descriptors Class 4; Medical; Medical Students; Mentors; Minority; Molecular; Molecular Genetic; Molecular Genetics; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nature; Neurosciences; Nomascus; Organ System, Cardiovascular; Organization Charts; Ph.D.; PhD; Phase; Physiologic; Physiological; Pilot Projects; Play; Population; Population Sciences; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Prevention Research; Preventive Intervention; Preventive Medicine; Primary Care; Primary Care Physician; Primary Health Care; Primary Healthcare; Principal Investigator; Process; Productivity; Programs (PT); Programs [Publication Type]; Public Health; Public Health Practice; Qualifying; R & D; R&D; Recruitment Activity; Research; Research Activity; Research Associate; Research Institute; Research Personnel; Research Resources; Research Training; Researchers; Resolution; Resources; Role; Schools, Medical; Science; Scientist; Series; Shapes; Sight; Source; South Carolina; Strategic Planning; Structure; Students; Students, Medical; Surgeon; Symphalangus; Technology; Tissue Growth; Training Programs; U-Series Cooperative Agreements; United States; United States Centers for Disease Control; United States Centers for Disease Control and Prevention; United States National Institutes of Health; Universities; Vascular, Heart; Vision; base; black American; cardiovascular disorder; circulatory system; clinical investigation; disease/disorder; expectation; experience; genetic epidemiology; geographic site; graduate student; health disparities; health disparity; innovate; innovation; innovative; intervention program; medical schools; member; next generation; novel; ontogeny; organizational structure; pilot study; population based; post-doc; post-doctoral; prevent; preventative medicine; preventing; preventional intervention strategy; programs; public health medicine (field); recruit; research and development; role model; social role; statistics/biometry; success; vascular; working group",Cardiovascular Disease Preventive Intervention Program,,73461,ZHL1,Special Emphasis Panel,,7,695800,
7764620,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001518-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,COLUMBUS,UNITED STATES,,15,,US,OH,432296282,OHIO DOMESTIC VIOLENCE NETWORK,"CLINE, REBECCA ;",9005798;,5US4CE001518,01/30/2009,01/29/2012,,"THE OHIO DELTA PROJECT PROVIDES PRIMARY PREVENTION FOCUSED MATERIALS, TRAINING, A",,1518,ZCE1,Special Emphasis Panel,,2,303123,
7764624,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001519-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,WARWICK,UNITED STATES,,02,,US,RI,028881539,RHODE ISLAND COALITION AGAINST DOM VIOL,"RIOS, LUCY ;",8996621;,5US4CE001519,01/30/2009,01/29/2012,,DOMESTIC VIOLENCE PREVENTION ENHANCEMENT AND LEADERSHIP THROUGH ALLIANCES (DELTA),,1519,ZCE1,Special Emphasis Panel,,2,241751,
7764625,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001520-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,MADISON,UNITED STATES,,02,171537392,US,WI,53703,WISCONSIN COALITION AGAINST DOMESTIC VIO,"SEGER, PATTI ;",9596982;,5US4CE001520,01/30/2009,01/29/2012,,WISCONSIN DELTA III PROJECT,,1520,ZCE1,Special Emphasis Panel,,2,356200,
7764627,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001521-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,TALLAHASSEE,UNITED STATES,,02,053274101,US,FL,32301,FLORIDA COALITION AGAINST DOMESTIC VIOL,"CARLSON, BRANDY E;",9802339;,5US4CE001521,01/30/2009,01/29/2012,,"FLORIDA'S DELTA INITIATIVE: UTILIZING PRIMARY PREVENTION PRINCIPLES, CONCEPTS, AN",,1521,ZCE1,Special Emphasis Panel,,2,395155,
7764628,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001522-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,JUNEAU,UNITED STATES,,00,,US,AK,998011234,ALASKA NETWORK/DOM VIOL/SEXUAL  ASSAULT,"GRASSGREEN, LORI ;",9686081;,5US4CE001522,01/30/2009,01/29/2012,,ALASKA DOMESTIC VIOLENCE PREVENTION ENHANCEMENT AND LEADERSHIP TRHOUGH ALLIANCES,,1522,ZCE1,Special Emphasis Panel,,2,322030,
7764631,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001523-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,SACRAMENTO,UNITED STATES,,05,,US,CA,958143608,CALIFORNIA PARTNERSHIP TO END DOM VIOL,"SHABAZZ, TARA ;",9010751;,5US4CE001523,01/30/2009,01/29/2012,,CALIFORNIA DELTA PROGRAM,,1523,ZCE1,Special Emphasis Panel,,2,405969,
7764632,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001524-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,DURHAM,UNITED STATES,,04,,US,NC,277013694,NORTH CAROLINA COALTN AGNST DOM VIOLENCE,"BURGESS-JOHNSON, APRIL ;",9596685;,5US4CE001524,01/30/2009,01/29/2012,,NCCADV DELTA PROJECT III,,1524,ZCE1,Special Emphasis Panel,,2,250673,
7764633,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001525-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,RICHMOND,UNITED STATES,,03,,US,VA,232304911,VA SEXUAL/DOMESTIC VIOLENCE ACTION ALLIA,"CASCONE, LIZ ;",9686125;,5US4CE001525,01/30/2009,01/29/2012,,VIRGINIA SEXUAL AND DOMESTIC VIOLENCE ACTION ALLIANCE DELTA III,,1525,ZCE1,Special Emphasis Panel,,2,337887,
7764634,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001526-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,TOPEKA,UNITED STATES,,02,,US,KS,66603,KANSAS COALITION AGAINST SEXUAL/DOM VIOL,"BARNETT, SANDRA C;",9009103;,5US4CE001526,01/30/2009,01/29/2012,,KANSAS DELTA PROJECT,,1526,ZCE1,Special Emphasis Panel,,2,264824,
7764635,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001527-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,WILMINGTON,UNITED STATES,,00,025256293,US,DE,19801,DELAWARE COALITION AGAINST DOMESTIC VIOL,"DUCKWORTH, NOEL ;",9686147;,5US4CE001527,01/30/2009,01/29/2012,,DELTA IPV PRIMARY PREVENTION PROJECT OF THE DELAWARE COALITION AGAINST DOMESTIC V,,1527,ZCE1,Special Emphasis Panel,,2,218979,
7764636,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001528-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,HELENA,UNITED STATES,,00,036541035,US,MT,596015750,MONTANA COALITION AGNST DOM/SEXUAL VIOL,"LANE, KAREN ;",9009793;,5US4CE001528,01/30/2009,01/29/2012,,DOMESTIC VIOLENCE PREVENTION ENHANCEMENT AND LEADERSHIP THROUGH ALLIANCES DELTA ,,1528,ZCE1,Special Emphasis Panel,,2,265897,
7764637,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001529-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,OKEMOS,UNITED STATES,,08,,US,MI,48864,MI COALITION AGAINST DOMESTIC/SEX VIOLNC,"LEMMER, TAMMY ;",9005814;,5US4CE001529,01/30/2009,01/29/2012,,MICHIGAN PARTICIPATION IN DELTA 3,,1529,ZCE1,Special Emphasis Panel,,2,322117,
7764638,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001530-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,ALBANY,UNITED STATES,,21,790031702,US,NY,12208,NYS COALITION AGAINST DOMESTIC VIOLENCE,"CASTELLE, LORIEN ;",9686181;,5US4CE001530,01/30/2009,01/29/2012,,DOMESTIC VIOLENCE PREVENTION ENHANCEMENT AND LEADERSHIP THROUGH ALLIANCES DELTA ,,1530,ZCE1,Special Emphasis Panel,,2,351652,
7764639,US4,CE,5,,01/30/2010,01/29/2011,CE-09-901,5US4CE001531-02,,NCIPC:;,2010,NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL,,BISMARCK,UNITED STATES,,00,,US,ND,585014046,NORTH DAKOTA CNCL/ABUSED WOMEN'S SRVCS,"MOE LITKE, KELLY ;",9693987;,5US4CE001531,01/30/2009,01/29/2012,,A COLLABORATIVE AGREEMENT TO BUILD CAPACITY TO IMPLEMENT AND EVALUATE INTIMATE PA,,1531,ZCE1,Special Emphasis Panel,,2,218979,
7758847,R01,AI,7,,02/01/2010,01/31/2011,,7R01AI066208-04,,NIAID:364197;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"GUNN, JOHN S;",1950573;,7R01AI066208,02/01/2007,01/31/2012,"Affect; Area; Bacteria; Bile; Bile Juice; Bile Salt; Bile fluid; Binding; Binding (Molecular Function); Body Tissues; Carrier State; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell-Extracellular Matrix; Cells; Cellular Migration; Cholelithiasis; Chronic; Cities; Data; Detergents; Development; Digestion; ECM; Enteric Fever; Environment; Epithelial Cells; Epithelium; Eukaryote; Eukaryotic Cell; Extracellular Matrix; Gall Bladder; Gallbladder; Gallbladder / Biliar; Gallbladder Calculus; Gallbladder Stone; Gallbladder/Biliary system; Gallstones; Gastrointestinal Tract, Gall Bladder; Gene Expression Alteration; Gene Transcription; Genes; Genetic Transcription; Goals; Human; Human, General; In Vitro; Individual; Infection; Intracellular Communication and Signaling; Invaded; Killings; Knowledge; Life; Lipids; Location; Maintenance; Maintenances; Man (Taxonomy); Man, Modern; Mediating; Mexico; Microbial Biofilms; Modeling; Molecular; Molecular Interaction; Motility; Motility, Cellular; Organ; Organism; Pathogenesis; Phenotype; Play; Population; Process; Property; Property, LOINC Axis 2; Proteins; RNA Expression; Regulatory Pathway; Reporter; Resistance; Risk; Role; S. typhi; S. typhosa; S.Typhi; Salmonella; Salmonella enterica serovar Typhi; Salmonella typhi; Salmonella typhosa; Salts, Bile; Sensory; Signal Transduction; Signal Transduction Systems; Signaling; Site; Surface; Testing; Therapeutic; Tissues; Transcription; Transcription, Genetic; Translating; Translatings; Transmission; Typhoid; Typhoid Fever; Typhoids; Typhus, Abdominal; Virulence; Work; anti-microbial; antimicrobial; base; bile salts; biofilm; biological signal transduction; cell motility; cholelith; disease carrier state; eukaryotida; experiment; experimental research; experimental study; gene product; interest; language translation; living system; microbial; mutant; prevent; preventing; research study; resistant; response; sensory mechanism; sensory system; social role; transmission process","Bile, Biofilms and Salmonella Gallbladder Carriage",,66208,ZRG1,Special Emphasis Panel,,4,364197,
7763885,R01,CA,7,,02/01/2010,01/31/2011,PA-07-070,7R01CA095512-07,,NCI:250821;,2010,NATIONAL CANCER INSTITUTE,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"PERROTTI, DANILO ;",6882757;,7R01CA095512,04/01/2002,01/31/2013,"1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-; A1 protein; ATP[{..}]protein-tyrosine O-phosphotransferase; Affect; Apoptosis; Apoptosis Pathway; Automobile Driving; BCR-ABL; BCR-ABL Oncoprotein; BCR-ABL Protein Tyrosine Kinase; BCR/ABL; Biology; Blast Cell; Blast Crisis; Blast Phase; Blast Phase CML; Blast Phase Chronic Granulocytic Leukemia; Blast Phase Chronic Myelocytic Leukemia; Blast Phase Chronic Myelogenous Leukemia; Blast Phase Chronic Myeloid Leukemia; Blastic Phase CML; Blastic Phase Chronic Granulocytic Leukemia; Blastic Phase Chronic Myelocytic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myeloid Leukemia; Blasts; Blood (Leukemia); Bone Marrow; C-EBP Nuclear Protein; C-EBP Proteins; C/EBP; CAAT-Enhancer-Binding Proteins; CCAAT Sequence-Specific DNA-Binding Proteins; CCAAT-Enhancer-Binding Proteins; CD117 Antigens; CD34; CD34 gene; Cancers; Cell Communication and Signaling; Cell Death, Programmed; Cell Line; Cell Lines, Strains; Cell Signaling; CellLine; Cells; Chronic Myeloid Leukemia; Chronic Phase CML; Chronic Phase Chronic Granulocytic Leukemia; Chronic Phase Chronic Myelocytic Leukemia; Clinical Trials; Clinical Trials, Unspecified; Coleonol; Dasatinib; Development; Disease; Disease Progression; Disorder; Drivings, Automobile; Drugs; Dysfunction; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Export, Nuclear; Ferrata cell; Forskolin; Functional disorder; Fusion Proteins, bcr-abl; Gene Expression; Genes, Regulator; Goals; Granulocytic Leukemia, Chronic, Stable-Phase; HEK3; HPCA1; Hematohistioblast; Hematopoietic; Hemocytoblast; Hemohistioblast; Imatinib; In Vitro; Intermediary Metabolism; Intracellular Communication and Signaling; Investigation; Knowledge; LEUKCL; Leukemia, Granulocytic, Chronic; Leukemia, Granulocytic, Chronic-Phase; Leukemia, Myelogenous, Chronic-Phase; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Stable-Phase; Leukemias, General; Leukemic Cell; Leukemogenesis/Lymphomagenesis; Link; MDM 2; MDM2; MDM2 gene; METBL; Malignant Cell; Malignant Neoplasms; Malignant Tumor; Marrow; Mast Cell Growth Factor Receptor; Medication; Messenger RNA; Metabolic Processes; Metabolism; Micro RNA; MicroRNAs; Modeling; Molecular; Mother Cells; Myelocytic Leukemia, Chronic; Myelogenous Leukemia, Chronic; Myelogenous Leukemia, Chronic, Chronic-Phase; Myeloid Leukemia, Chronic; Myeloid Leukemia, Chronic, Chronic-Phase; Myeloid Leukemia, Chronic, Stable-Phase; Nuclear; Nuclear Export; Oncogenic; Outcome; PP2A; PP2A Subunit B Prime; PPP2R4; PR53; PTK; PTPA; Pathway interactions; Patient Care; Patient Care Delivery; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Phosphotyrosyl Phosphatase Activator; Physiopathology; Process; Progenitor Cells; Protein Phosphatase 2A Regulatory Subunit B Prime; Protein Phosphatase 2A Regulatory Subunit PR53; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Proteins; Proto-Oncogene Protein c-kit; RF-C protein; RNA Binding; RNA, Messenger; RNA-Binding Proteins; Regulation; Regulator Genes; Reporting; Research; Research Specimen; Resistance; Reticuloendothelial System, Bone Marrow; Role; SCF Receptor; Signal Transduction; Signal Transduction Systems; Signaling; Specimen; Staging; Stem Cell Factor Receptor; Stem cells; Therapeutic Intervention; Transcriptional Regulatory Elements; Translating; Translatings; Translations; Tumor Suppressor Proteins; Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; Work; activator 1 protein; anticancer research; base; bcr-abl Fusion Proteins; biological signal transduction; c kit; c-kit Protein; c-kit Receptor; cancer cell; cancer research; clinical investigation; cultured cell line; disease/disorder; driving; drug/agent; gene product; hydroxyaryl protein kinase; in vivo; intervention therapy; kinase inhibitor; kit Proto-Oncogene Protein; language translation; leukemia; leukemogenesis; loss of function; mRNA; malignancy; miRNA; mouse model; neoplasm/cancer; p145(c-kit); p145c-kit; p53-Binding Protein Gene; pathophysiology; pathway; prevent; preventing; progenitor; protein K; protein expression; public health relevance; regulatory gene; replication factor C; resistant; response; social role; stem; therapeutic target; trans acting element; tumor suppressor; tyrosyl protein kinase",Role of RNA Binding Proteins in BCR/ABL Leukemogenesis,,95512,CAMP,Cancer Molecular Pathobiology Study Section,,7,250821,
7761223,R01,CA,7,,02/01/2010,01/31/2011,PA-07-070,7R01CA122163-03,,NCI:540339;,2010,NATIONAL CANCER INSTITUTE,,COLUMBUS,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"SCHWARTZBAUM, JUDITH ;",1938878;,7R01CA122163,04/01/2008,01/31/2013,"Accounting; Adult Glioma; Affect; Age; Allergic; Allergy; Anti-Inflammatories; Anti-Inflammatory Agents; Anti-inflammatory; Antiinflammatories; Antiinflammatory Agents; Asthma; Astrocytes; Astrocytoma, Grade IV; Astrocytus; Astroglia; B cell activating factor; B cell growth factor; B-Cell Differentiation Factor-1; B-Cell Growth Factor-1; B-Cell Growth Factor-I; B-Cell Proliferating Factor; B-Cell Stimulating Factor; B-Cell Stimulating Factor-1; B-Cell Stimulation Factor-1; B-Cell Stimulatory Factor-1; BAF; BCDF-1; BCGF; BCGF-1; BCSF 1; BSF-1; BSF1; BSF1 (B cell stimulating factor 1); Bayesian Networks; Binetrakin; Bone-Derived Transforming Growth Factor; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Bronchial Asthma; CSIF; CSIF-10; Cancer Patient; Cancer of Brain; Cancers; Case-Base Studies; Case-Comparison Studies; Case-Compeer Studies; Case-Control Studies; Case-Referent Studies; Case-Referrent Studies; Causality; Cause of Death; Cells; Central Nervous System; Co-Stimulator; Code; Coding System; Common Rat Strains; Computer Programs; Computer software; Costimulator; Country; Cytokine Synthesis Inhibitory Factor; Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced); DNA; Data; Deoxyribonucleic Acid; Development; Diagnosis; Drugs; Encephalitis; Environment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology Research; Epidermal Thymocyte Activating Factor; Etiology; Forecast of outcome; Gamma interferon; Genes; Genetic Polymorphism; Genotype; Glial Cell Tumors; Glial Neoplasm; Glial Tumor; Glioblastoma; Glioma; Goals; Grade IV Astrocytic Neoplasm; Grade IV Astrocytic Tumor; Hematopoietic Cell Tumor; Hematopoietic Malignancies; Hematopoietic Neoplasms; Hematopoietic Neoplasms including Lymphomas; Hematopoietic Tumor; Hematopoietic and Lymphoid Cell Neoplasm; Hematopoietic and Lymphoid Neoplasms; Hematopoietic, Including Myeloma; Hortega cell; Human; Human, General; Hypersensitivity; IFN-Gamma; IFN-g; IFNG; IL-10; IL-13; IL-2; IL-4; IL10; IL10A; IL13; IL2; IL2 Protein; IL4; IL4 Protein; INFLM; Immune; Immune Function, Cellular; Immune system; Immunosuppressants; Immunosuppressive Agents; Inflammation; Inflammation, Brain; Inflammatory; Interferon Gamma; Interferon Type II; Interferon gamma (human lymphocyte protein moiety reduced); Interferon, Immune; Interferon-gamma; Interleukin 10 Precursor; Interleukin 2; Interleukin 2 Precursor; Interleukin II; Interleukin-10; Interleukin-13; Interleukin-2; Interleukin-4; Interleukin-4 Precursor; Interleukine 2; Interleukine 2 Precursor; Interleukine II; Interleukins; Interview; Literature; Logistics; Lymphocyte Mitogenic Factor; Lymphocyte Stimulatory Factor 1; MCGF-2; Malignant Hematopoietic Neoplasm; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Brain; Malignant neoplasm of brain; Mammals, Rats; Man (Taxonomy); Man, Modern; Mast Cell Growth Factor-2; Medication; Microglia; Milk Growth Factor; Mitogenic Factor; Neoplasms of Neuroglia; Nervous System, CNS; Neuraxis; Neuroglial Neoplasm; Neuroglial Tumor; Participant; Pathway interactions; Patient Self-Report; Patients; Pharmaceutic Preparations; Pharmaceutical Preparations; Platelet Transforming Growth Factor; Polymorphism (Genetics); Polymorphism, Genetic; Polymorphism, Single Base; Population; Predisposition; Prevention; Probability; Production; Prognosis; Property; Property, LOINC Axis 2; Public Health; Rat; Rattus; Regulatory T-Lymphocyte; Relative; Relative (related person); Research; Risk; Role; SNP; SNPs; Sampling; Screening procedure; Self-Report; Single Nucleotide Polymorphism; Site; Software; Susceptibility; Symptoms; T cell growth factor; T-Cell Growth Factor; T-Cell Growth Factor 2; T-Cell Stimulating Factor; T-Lymphocyte, Regulatory; TGF B; TGF-beta; TGFbeta; Testing; Thymocyte Stimulating Factor; Time; Transforming Growth Factor beta; Tumor Immunity; Tumors of Neuroglia; Variant; Variation; angiogenesis; base; biomarker; blood cancer; body system, allergic/immunologic; brain cell; cohort; computer based statistical methods; computer program/software; cytokine; disease causation; disease etiology; disease/disorder etiology; disorder etiology; drug/agent; forest; genetic variant; gitter cell; glioblastoma multiforme; hazard; immune function; immunosuppressive; improved; insight; lFN-Gamma; malignancy; mesoglia; microglial cell; microgliocyte; neoplasm/cancer; organ system, allergic/immunologic; outcome forecast; pathway; peripheral blood; perivascular glial cell; polymorphism; population based; prevent; preventing; public health medicine (field); public health relevance; screening; screenings; self tolerance (immune); sex; social role; spongioblastoma multiforme; statistical methods, computer based; stem; tumor; tumor growth; tumors in the brain; unspecified interleukin; years of life lost",Allergic Condition Susceptibility Polymorphisms and Glioma Risk,"The public health relevance of the attached application is two-fold. First, it will allow understanding of the role of the immune system in glioma etiology. Although this tumor is rare, it accounts for more years of life lost than any other tumor. Second, it will determine whether treatment for allergies blocks their natural glioma- preventing properties. This second point has application to the large number of people who use medication to treat their allergies.",122163,EPIC,Epidemiology of Cancer Study Section,,3,540339,
7758822,R01,CA,7,,02/01/2010,01/31/2011,PA-07-070,7R01CA124541-03,,NCI:336489;,2010,NATIONAL CANCER INSTITUTE,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"CROCE, CARLO M;",1872221;,7R01CA124541,04/01/2008,01/31/2013,"13q14; ALL - Acute Lymphocytic Leukemia; Aberrant Chromosome; Abnormalities, Chromosomal; Acute Lymphoid Leukemia; Anti-Cancer Agents; Anti-Oncogenes; Anti-Tumor Agents; Anti-Tumor Drugs; Antineoplastic Agents; Antineoplastic Drugs; Antineoplastics; Antioncogenes; Antiproliferative Agents; Antiproliferative Drugs; Apoptosis; Apoptosis Pathway; B blood cells; B cell tumor; B-Cell CLL; B-Cell CLL/Lymphoma 2 Gene; B-Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphogenous Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Cell Lymphocytic Neoplasm; B-Cell Neoplasm; B-Cells; B-Lymphocytes; B-Lymphocytic Leukemia; B-Lymphocytic Leukemia, Chronic; B-lineage tumor; BCL2; BCL2 gene; Birth; Body Tissues; Breast; Burkitt Lymphoma; Burkitt Tumor; Burkitt's Lymphoma/Leukemia; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cancer Cause; Cancer Drug; Cancer Etiology; Cancer Genes; Cancer of Breast; Cancer of Lung; Cancer of the Fundus of the Stomach; Cancer of the Gastric Body; Cancer of the Gastric Cardia; Cancer of the Gastric Fundus; Cancer of the Gastric Pylorus; Cancer of the Pylorus of the Stomach; Cancer-Promoting Gene; Cancers; Cell Death, Programmed; Cell Function; Cell Process; Cell physiology; Cellular Function; Cellular Physiology; Cellular Process; Chemotherapeutic Agents, Neoplastic Disease; Chromosomal Aberrations; Chromosomal Alterations; Chromosome Aberrations; Chromosome Alterations; Chromosome Anomalies; Chromosome Mapping; Chromosome abnormality; Chronic B-Cell Leukemias; Chronic Lymphatic Leukemia; Chronic Lymphocytic Leukemia; Chronic Lymphogenous Leukemia; Colon Cancer; Colon Carcinoma; Colonic Carcinoma; Cytogenetic Aberrations; Cytogenetic Abnormalities; DLBCL; DNA Sequence Rearrangement; Degradation, mRNA; Development; Diffuse Large B-Cell Lymphoma; Diffuse non-Hodgkin's lymphoma, large cell; Down-Regulation; Down-Regulation (Physiology); Downregulation; Emerogenes; Enhancers; Expression Profiling; Expression Signature; Family; Gastric Cancer; Gene Action Regulation; Gene Chips; Gene Expression; Gene Expression Chip; Gene Expression Regulation; Gene Localization; Gene Mapping; Gene Mapping, Total Human and Non-Human; Gene Regulation; Gene Regulation Process; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, bcl-2; Genetic Translation; Genetics, Gene Mapping; Human; Human, General; Immune Globulins; Immunoglobulins; Immunoglobulins / Antibodies; Indolent; Leukemia, B-Cell; Leukemia, Lymphocytic, Acute; Leukemogenesis/Lymphomagenesis; Linkage Mapping; Liquid substance; Lung; Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Chronic; Lymphocytic Leukemia, B-Cell; Lymphocytic Leukemia, Chronic, B-Cell; Malignant; Malignant - descriptor; Malignant Gastric Neoplasm; Malignant Gastric Tumor; Malignant Neoplasms; Malignant Pancreatic Neoplasm; Malignant Thyroid Gland Neoplasm; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Lung; Malignant Tumor of the Stomach; Malignant Tumor of the Thyroid; Malignant Tumor of the Thyroid Gland; Malignant neoplasm of breast; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of stomach; Malignant neoplasm of thyroid; Mammals, Mice; Man (Taxonomy); Man, Modern; Mice; Mice, Transgenic; Micro RNA; MicroRNAs; Molecular Fingerprinting; Molecular Profiling; Murine; Mus; Nucleotides; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Oncogenesis; Oncogenic; Pancreas Cancer; Pancreatic Cancer; Parturition; Pathogenesis; Phenotype; Precursor Cell Lymphoblastic Leukemia; Precursor Lymphoblastic Leukemia; Prevention; Prevention strategy; Preventive strategy; Process; Pulmonary Cancer; Pulmonary malignant Neoplasm; Rearrangement; Respiratory System, Lung; Role; Small Non-Cleaved Cell Lymphoma, Burkitt's Type; Small RNA; Solid; Solid Neoplasm; Solid Tumor; Stomach Cancer; Subcellular Process; T-Cell Neoplasm; T-Cell and NK-Cell Neoplasm; Testing; Thyroid Cancer; Tissues; Transforming Genes; Transgenic Mice; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor-Specific Treatment Agents; Up-Regulation; Up-Regulation (Physiology); Upregulation; acute lymphatic leukemia; acute lymphogenous leukemia; acute lymphomatic leukemia; anticancer agent; anticancer drug; base; biological adaptation to stress; ced9 homolog; chronic lymphoid leukemia; fluid; genetic mapping; large cell Diffuse non-Hodgkin's lymphoma; leukemogenesis; liquid; lung cancer; mRNA Transcript Degradation; mRNA Translation; malignancy; malignant breast neoplasm; malignant stomach neoplasm; miRNA; molecuar profile; molecular signature; neoplasm/cancer; oncosuppressor gene; overexpression; prevent; preventing; public health relevance; pulmonary; reaction; crisis; social role; stress response; stress; reaction; tumorigenesis",Role of miR155 in Leukemogenesis,,124541,CAMP,Cancer Molecular Pathobiology Study Section,,3,336489,
7751241,R01,DA,7,,12/01/2009,11/30/2010,PA-07-070,7R01DA012815-11,,NIDA:351312;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,PHILADELPHIA,UNITED STATES,PATHOLOGY,01,057123192,US,PA,19122,TEMPLE UNIVERSITY,"HO, WENZHE ;",2139021;,7R01DA012815,02/01/2000,11/30/2013,"AIDS Virus; AIDS neuropathy; Address; Antiviral Agents; Antiviral Drugs; Antivirals; Ants; Astrocytes; Astrocytus; Astroglia; Blood; Blood monocyte; Brain; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cells; Cells, CD4; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Complex; Contin, MS; Data; Defense Mechanisms; Development; Diacetylmorphine; Diamorphine; Disease; Disorder; Disturbance in cognition; Drug abuse; Elements; Encephalon; Encephalons; Euler-Gaddum Substance P; Figs; Figs - dietary; Goals; HIV-1; HIV-I; HIV1; Heroin; Hortega cell; Host Defense Mechanism; Human; Human immunodeficiency virus 1; Human, General; IFN; Immune; Immune system; Immunity, Innate; Immunity, Native; Immunity, Natural; Immunity, Non-Specific; Immunodeficiency Virus Type 1, Human; Impaired cognition; Impairment; In Vitro; Infection; Infumorph; Injury; Interferons; Investigation; Kadian; Link; MSir; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Messenger RNA; Microglia; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester); Morphine; Natural Immunity; Nerve Cells; Nerve Unit; Nervous System, Brain; Neural Cell; Neurocognitive; Neurocyte; Neuronal Injury; Neurons; Neuropeptides; Opioid; Oramorph; Oramorph SR; PBMC; Peripheral Blood Mononuclear Cell; Play; Predisposition; RNA, Messenger; Regulation; Research Specimen; Reticuloendothelial System, Blood; Risk Factors; Role; Roxanol; SP(1-11); Series; Specimen; Statex SR; Substance P; Susceptibility; System; System, LOINC Axis 4; T4 Cells; T4 Lymphocytes; abuse of drugs; abuses drugs; base; body system, allergic/immunologic; brain tissue; cell type; cofactor; cognitive dysfunction; cognitive loss; cognitively impaired; disease/disorder; gitter cell; helper T cell; human T cell leukemia virus III; human T lymphotropic virus III; in vivo; mRNA; macrophage; mesoglia; microglial cell; microgliocyte; monocyte; neuroAIDS; neurokinin 1; neuron injury; neuronal; organ system, allergic/immunologic; peripheral blood; perivascular glial cell; protein expression; psychological defense mechanism; public health relevance; social role","Drug Abuse, Sustance P and HIV",,12815,ZRG1,Special Emphasis Panel,,11,351312,
7752524,R01,DA,7,,12/01/2009,11/30/2010,PA-07-226,7R01DA025036-02,,NIDA:277720;,2010,NATIONAL INSTITUTE ON DRUG ABUSE,,NEW YORK,UNITED STATES,ANESTHESIOLOGY,15,621889815,US,NY,100323702,COLUMBIA UNIVERSITY HEALTH SCIENCES,"MORON-CONCEPCION, JOSE A;",8347790;,7R01DA025036,01/01/2009,11/30/2013,"21+ years old; AMPA Receptors; Addiction, Drug; Addiction, Opiate; Adult; Ammon Horn; Analgesic Agents; Analgesic Drugs; Analgesic Preparation; Analgesics; Animal Model; Animal Models and Related Studies; Anodynes; Antinociceptive Agents; Antinociceptive Drugs; Behavior; Behavior Disorders; Behavioral; Biochemical; CNS plasticity; Cells; Chemical Dependence; Chronic; Contin, MS; Cornu Ammonis; Dependence, Drug; Dependence, Opiate; Development; Drug Addiction; Drug Dependency; Drug usage; Drugs; Dysfunction; Effects, Longterm; Electron Microscopy; Exposure to; Functional disorder; Glutamate Receptor; Glutamates; Goals; Hippocampus; Hippocampus (Brain); Human; Human, Adult; Human, General; Incentives; Infumorph; Intervention; Intervention Strategies; Investigation; Kadian; L-Glutamate; Lead; Learning; Long-Term Effects; MSir; Man (Taxonomy); Man, Modern; Medication; Memory; Morphia; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-; Morphine; Motor; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Neural Cell; Neural Transmission; Neurocyte; Neuronal Plasticity; Neuronal Transmission; Neurons; Opiate Addiction; Opiates; Opioid; Oramorph; Oramorph SR; Pathway interactions; Pb element; Pharmaceutic Preparations; Pharmaceutical Preparations; Physiopathology; Process; Property; Property, LOINC Axis 2; Receptors, AMPA; Relapse; Research; Role; Roxanol; Statex SR; Stimulus; Synapses; Synaptic; Synaptic Transmission; Synaptic plasticity; System; System, LOINC Axis 4; Testing; Time; Transmission; abused drugs; addiction; adult human (21+); analgesia; behavioral disorder; behavioral sensitization; drug of abuse; drug relapse; drug use; drug/agent; drugs abused; drugs of abuse; experiment; experimental research; experimental study; heavy metal Pb; heavy metal lead; hippocampal; incentive; inducement; innovate; innovation; innovative; insight; interest; interventional strategy; model organism; neural plasticity; neuroadaptation; neuronal; neuroplasticity; neurotransmission; new approaches; novel; novel approaches; novel strategies; novel strategy; opiate abuse; opioid abuse; opioid addiction; opioid dependence; pathophysiology; pathway; public health relevance; research study; response; social role; synapse function; synaptic function; tool; trafficking; transmission process; treatment strategy",Mechanisms underlying opiate-induced neuroplasticity at the synapse," Project Narrative The long-term effects of repeated exposure to drugs of abuse are a major point of interest in the study of the pathophysiology of drug addiction. The repeated administration of a variety of potentially addictive drugs, such as morphine, produces increases in their motor-stimulant effects (called behavioral sensitization) and their incentive-motivational properties that persist many months after cessation of drug administration, thus mimicking long-term sensitivity to drugs observed in human addicts. The present proposal will analyze the mechanisms underlying morphine-induced sensitization by characterizing the modulation and alteration of hippocampus neurotransmission at the synaptic level upon repeated morphine administration.",25036,NTRC,"Neurotransporters, Receptors, and Calcium Signaling Study Section",,2,277720,
7762745,R01,DK,7,,02/01/2010,01/31/2011,PA-07-070,7R01DK081654-02,,NIDDK:327902;,2010,NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES,,COLUMBUS,UNITED STATES,NEUROSCIENCES,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"ZHU, MICHAEL X;",1968292;,7R01DK081654,02/01/2009,01/31/2013,"2-(Acetyloxy)-N,N,N-trimethylethanaminium; Abbreviations; Acetylcholine; Acute; Agents, Muscarinic; Ailmentary System; Alimentary Canal; Alimentary System; Binding; Binding (Molecular Function); Binding Sites; Biochemistry; Blood Coagulation Factor IV; C Cell; C-terminal; Ca++ element; Calcium; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Calmodulin; Cations; Cavia; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell Surface Receptors; Cells; Cellular Matrix; Cellular Migration; Characteristics; Chemistry, Biological; Cholinergic Agonists, Muscarinic; Coagulation Factor IV; Codependence; Codependency; Colitis, Mucous; Colon, Irritable; Combining Site; Complex; Coupling; Cytoskeletal System; Cytoskeleton; DISSEC; DNA Molecular Biology; Dependence; Digestive System; Digestive System (All Sites); Digestive Tract; Dissection; Dysfunction; Electrophysiology; Electrophysiology (science); Enteral; Enteric; Environment; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Factor IV; Family; Functional disorder; G-Protein Signaling Pathway; G-Proteins; GI Tract; GTP-Binding Proteins; GTP-Regulatory Proteins; Gastrointestinal Body System; Gastrointestinal Tract; Gastrointestinal tract structure; Genetic; Goals; Guanine Nucleotide Coupling Protein; Guanine Nucleotide Regulatory Proteins; Guinea Pigs; Heterotrimeric G-Proteins; Heterotrimeric GTP-Binding Proteins; Histamine-Sensitizing Factor; IAP Pertussis Toxin; ICC (Interstitial cell of Cajal); Inflammatory Bowel Diseases; Inflammatory Bowel Disorder; Inflammatory Intestinal Disease; Inflammatory Intestinal Disorder; Interstitial Cell of Cajal; Interstitial cell of Cajal (ICC); Intestinal; Intestines; Intracellular Communication and Signaling; Irritable Bowel Syndrome; Islet-Activating Protein; Isoforms; Knock-out; Knockout; Knowledge; Learning; Lecithinase C; Leiomyocyte; Light; Lymphocytosis-Promoting Factor; Mammals, Guinea Pigs; Mammals, Mice; Mediating; Membrane; Mice; Mice, Transgenic; Minor; Models, Molecular; Molecular; Molecular Biology; Molecular Interaction; Molecular Models; Motility; Motility, Cellular; Motor Cell; Motor Neurons; Murine; Mus; Muscarinic Acetylcholine Receptor; Muscarinic Agonists; Muscarinics; Muscle Cell Contraction; Muscle Cells; Muscle Cells, Mature; Muscle Contraction; Muscle, Involuntary; Muscle, Smooth; Muscular Contraction; Mutagenesis, Site-Directed; Myocytes; Myocytes, Smooth Muscle; Nerve; Nerve Transmitter Substances; Nervous; Neural Development; Neural Transmission; Neurites; Neurophysiology / Electrophysiology; Neurotransmitters; Nucleic Acid Biochemistry, Molecular Modeling; Organ System, Gastrointestinal; PIP2; Parafollicular Cell; Pathogenesis; Pertussigen; Pertussis Toxin; Phosphatidylinositol 4,5-Biphosphate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol-4,5-Bisphosphate; Phosphodiesterase Activating Factor; Phosphodiesterase Protein Activator; Phospholipase C; Photoradiation; Physiologic; Physiological; Physiology; Physiopathology; Play; Property; Property, LOINC Axis 2; Protein Isoforms; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; PtIns 4,5-P2; PtdInsP2; Reactive Site; Receptor Protein; Receptors, Cell Surface; Receptors, Muscarinic; Regulation; Relaxation; Research; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Signaling Pathway from G-Protein Families; Site; Site-Directed Mutagenesis; Site-Specific Mutagenesis; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Smooth muscle (tissue); Structure of thyroid parafollicular cell; Synaptic Transmission; System; System, LOINC Axis 4; TRP channel; TRP protein; TRP4 channel; TRP4 ion channel; TRP4 protein; TRPC4 ion channel; TRPC4 protein; Targeted DNA Modification; Targeted Modification; Transgenic Mice; Transmission; Urge Incontinence; Vascular constriction (function); Vasoconstriction; Visceral; Work; alimentary tract; base; biological signal transduction; bowel; cell motility; cholinergic; desensitization; digestive canal; gastrointestinal; gastrointestinal system; gene product; human disease; interdisciplinary approach; interest; intracellular skeleton; lipophosphodiesterase I; member; membrane structure; molecular modeling; motoneuron; mutant; neurodevelopment; neurotransmitter release; overexpression; pathophysiology; phosphatidylcholine cholinephosphohydrolase; protein complex; protein protein interaction; public health relevance; receptor; receptor coupling; receptor operated channel; social role; spastic colon; transmission process",Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells," This project focuses on the molecular mechanism of activation and regulation of muscarinic acetylcholine receptor-evoked cation current found in intestinal smooth muscle cells. The study is aimed to provide a better understanding on how neurotransmitters trigger membrane depolarization and the subsequent intracellular calcium increase to cause smooth muscle contraction in the gastrointestinal system. This will shed light on the pathogenesis and new treatment of a wide range of human diseases caused by smooth muscle dysfunctions, such as inflammatory bowel disease, irritable bowel syndrome, and urge incontinence.",81654,GCMB,Gastrointestinal Cell and Molecular Biology Study Section,,2,327902,
7784532,R01,GM,7,,02/01/2010,01/31/2011,PA-07-070,7R01GM067153-07,,NIGMS:369765;,2010,NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"ARTSIMOVITCH, IRINA ;",7047725;,7R01GM067153,02/01/2003,01/31/2013,"Address; Affect; Animal Model; Animal Models and Related Studies; Antibiotic Agents; Antibiotic Drugs; Antibiotics; Assay; Attenuated; Bacteria; Bacterial Gene Proteins; Bacterial Proteins; Bacteriophages; Binding; Binding (Molecular Function); Binding Sites; Bioassay; Biochemical; Biochemical Genetics; Biologic Assays; Biological Assay; Bypass; C-terminal; CAPS; Capsules; Catalysis; Cell Communication and Signaling; Cell Signaling; Cell Wall; Cells; Chromatin; Combining Site; Complex; DISSEC; DNA; DNA Sequence; DNA lesion; DNA-Binding Proteins; DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; Data; Deoxyribonucleic Acid; Dissection; E coli; E coli K12; EC 2.7.7.6; Elongation Factor; Enzymes; Erwinia chrysanthemi; Escherichia coli; Escherichia coli K12; Evolution; Factor, Elongation; Family; Fecundability; Fecundity; Fertility; Fluorescence; Gene Expression; Gene Expression Profile; Gene Products, Bacterial; Gene Products, RNA; Gene Proteins; Gene Transcription; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic Transcription; Genetic Translation; Genetic defect; Genetic, Biochemical; Genome, Human; Goals; Grant; Human; Human Genome; Human, General; In Vitro; In element; Indium; Insecta; Insects; Intracellular Communication and Signaling; Invertebrates, Insects; K. pneumoniae; Kinetic; Kinetics; Klebsiella pneumonia bacterium; Klebsiella pneumoniae; Life; Man (Taxonomy); Man, Modern; Measurement; Mediating; Microarray Analysis; Microarray-Based Analysis; Miscellaneous Antibiotic; Models, Molecular; Modification; Molecular; Molecular Biology Techniques; Molecular Configuration; Molecular Conformation; Molecular Interaction; Molecular Models; Molecular Stereochemistry; Movement; Mutation; N-terminal; NH2-terminal; Nucleic Acid Biochemistry, Molecular Modeling; Nucleic Acids; Nucleoside-triphosphate[{..}]RNA nucleotidyltransferase (DNA-directed); Nucleotides; Operon; Ortholog; Orthologous Gene; Pasteurella pestis; Pathogenicity Factors; Pectobacterium chrysanthemi; Phages; Plants; Plants, General; Precipitation; Property; Property, LOINC Axis 2; Protein Family; Protein Gene Products; Protein/Amino Acid Biochemistry, Molecular Modeling; Proteins; RNA; RNA Expression; RNA Polymerases; RNA, Non-Polyadenylated; Radiation, X-Rays; Radiation, X-Rays, Gamma-Rays; Reactive Site; Recruitment Activity; Regulatory Protein; Regulon; Research; Research Resources; Resources; Ribonucleic Acid; Ribosomes; Roentgen Rays; Role; S. enterica; Salmonella enterica; Serratia; Side; Signal Transduction; Signal Transduction Systems; Signaling; Site; Specificity; Structure; Testing; Time; Transcript; Transcription; Transcription Elongation; Transcription Regulation; Transcription, Genetic; Transcriptional Control; Transcriptional Regulation; Translations; Two Hybrid; V. cholerae; V.cholerae; Vibrio cholerae; Vibrio comma; Virulence; Virulence Factors; Work; X-Radiation; X-Rays; Xrays; Y. pestis; Y.pestis; Yeast One Hybrid System; Yeast One/Two-Hybrid System; Yersinia pestis; bacterial virus; base; biological signal transduction; body movement; capsule (pharmacologic); conformation; conformational state; cross-link; crosslink; density; design; designing; experiment; experimental research; experimental study; gene expression signature; gene product; genetic regulatory protein; genome mutation; in vitro activity; in vivo; mRNA Translation; microarray technology; model organism; molecular modeling; mutant; novel; paralog; paralogous gene; pathogen; prevent; preventing; public health relevance; recruit; regulatory gene product; research study; social role; success; transcription factor; transcriptome; yeast two hybrid system",Mechanism of transcript elongation control by RfaH," This  project  aims  to  elucidate  the  mechanism  by  which  transcription  factor  RfaH  regulates  gene  expression.  The  rfaH  genes  are  present  in  human,  insect,  and  plant  pathogens; moreover, RfaH is essential for virulence in animal models. These studies  will  reveal  the  mechanism  of  RfaH  action,  elucidate  the  unique  role  of  the  its  DNA  target site in transcriptional control, and identify cellular RfaH targets which may be  uncharacterized virulence factors. ",67153,PCMB,Prokaryotic Cell and Molecular Biology Study Section,,7,369765,
8011832,R01,HD,7,,01/11/2010,12/31/2010,HD-07-005,7R01HD059215-03,,NICHD:486486;,2010,EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT,,COLUMBUS,UNITED STATES,OTHER HEALTH PROFESSIONS,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"PETRILL, STEPHEN A;",1890482;,7R01HD059215,01/01/2009,12/31/2012,"0-11 years old; 12-20 years old; Accounting; Address; Adolescence; Affect; Age; Award; Behavioral Genetics; Causality; Child; Child Youth; Childhood; Children (0-21); Cognition; Cognitive; Complex; Curriculum; Data; Development; Disease; Disorder; Educational Curriculum; Environment; Etiology; Exhibits; Fostering; Funding; GWAS; Genes; Genetic; Genetic Determinants of Behavior; Genetic Risk; Genetic analyses; Genetics, Behavioral; Goals; Home; Home environment; Human, Child; Impairment; Incidence; Individual; Internet; Job Environment; Job Location; Job Place; Job Setting; Job Site; Language; Learning; Learning Disabilities; Learning disability; Link; Literature; Math disability; Mathematics; Measures; Mediating; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Modeling; Outcome; Performance; Prevalence; Problem Solving; Problem behavior; Process; Process Measure; Programs (PT); Programs [Publication Type]; Psychometric; Psychometrics; Quantitative Genetics; Reading; Recruitment Activity; Relative; Relative (related person); Research; Sample Size; Sampling; Short-Term Memory; System; System, LOINC Axis 4; Time; Twin Multiple Birth; Twin Studies; Twins; WWW; Work; Work Location; Work Place; Work-Site; Workplace; Worksite; adolescence (12-20); base; behavior genetics; behavioral problem; children; cost; design; designing; disability; disease causation; disease etiology; disease/disorder; disease/disorder etiology; disorder etiology; experience; genetic analysis; genome wide association scan; genome wide association studies; genome wide association study; genome-wide scan; genomewide association scan; genomewide association studies; genomewide association study; genomewide scan; indexing; innovate; innovation; innovative; insight; meetings; pediatric; prevent; preventing; processing speed; programs; recruit; response; sex; skills; teacher; teenage; web; whole genome association studies; whole genome association study; work environment; work setting; working memory; world wide web; youngster",Genetics of Mathematical Cognition and Disabilities,,59215,ZHD1,Special Emphasis Panel,,3,486486,
7760556,R01,HL,7,,02/01/2010,01/31/2011,,7R01HL067176-08,,NHLBI:375000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,COLUMBUS,UNITED STATES,INTERNAL MEDICINE/MEDICINE,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"MARSH, CLAY B;",1871348;,7R01HL067176,06/05/2001,01/31/2012,"1-Phosphatidylinositol 3-Kinase; 47KDa platelet protein; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Affect; Animals; Apoptotic; Autoregulation; Binding; Binding (Molecular Function); Binding Sites; Biochemical Pathway; Bleo; Bleomycin; Bleomycin Antibiotic; Blood monocyte; CAP20 protein; CD115 Antigens; CDK-Interacting Protein 1; CDK2-associated protein 20 kDa; CDKN1 protein; CDKN1A; CDKN1A Protein; CIP-1 Protein; CREB; CREB1; CREB1 gene; CSF-1; CSF-1-R; CSF1; CSF1R Gene Product; Cdk2 inhibitor protein; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Signaling; Cell Survival; Cell Viability; Cell-Death Protease; Cells; Chemotaxis; Cip1 protein; Colony Stimulating Factor 1 Receptor; Colony-Stimulating Factor 1; Combining Site; Cyclin-Dependent Kinase Inhibitor 1A; Cyclins; Cytokines, Chemotactic; Data; Dimerization; Environment; Event; Exhibits; Female; Fibrosis; Funding; GFAC; Gene Transcription; Genetic Transcription; Goals; Grant; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Homeostasis; Homologous Chemotactic Cytokines; Host Defense; Human; Human, General; Humulin R; ICE-like protease; INFLM; In Vitro; Inflammation; Injury; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin, Regular; Intercrines; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Isoforms; L-Serine; L-Threonine; L-Tyrosine; Leiomyocyte; Lundbeck Brand of Bleomycin Sulfate; Lung; M-CSF; MCSF; MDA 6; Macrophage Colony Stimulating Factor I Receptor; Macrophage Colony-Stimulating Factor; Macrophage Colony-Stimulating Factor Receptor; Mammalia; Mammals; Mammals, General; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow monocyte; Mediating; Membrane; Metabolic Networks; Mice; Molecular; Molecular Interaction; Mononuclear; Murine; Mus; Myocytes, Smooth Muscle; Novolin R; P21; PI(3,4,5)P3; PI-3 Kinase; PI-3K; PI3-Kinase; PTK Receptors; Pathologic Processes; Pathological Processes; Pathway interactions; Patients; Phagocytes; Phagocytic Cell; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3-Hydroxykinase; Physiologic; Physiological; Physiological Homeostasis; Pic-1 protein (cyclin); Play; Production; Programs (PT); Programs [Publication Type]; Proliferating; Protein Dimerization; Protein Isoforms; Protein-Serine Kinase; Protein-Serine-Threonine Kinases; Protein-Threonine Kinase; Protein-Tyrosine Kinases, src; Proteins; Proto-Oncogene Protein fms; PtdIns 3-Kinase; RNA Expression; RTK; Rapamune; Rapamycin; Reactive Site; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor, CSF-1; Receptors, M-CSF; Regulation; Research Personnel; Researchers; Respiratory System, Lung; Role; SIS cytokines; Scheme; Second Messenger Systems; Second Messengers; Serine; Serine Kinase; Serine-Threonine Kinases; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sirolimus; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Symptoms; TYR; Threonine; Threonine Kinase; Transcription; Transcription, Genetic; Transmembrane Receptor Protein Tyrosine Kinase; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Tyrosine; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine, L-isomer; WAF-1 Protein; WAF1 CIP1; WAF1 protein; amebocyte; biological signal transduction; blood glucose regulation; c-fms Protein; caspase; cdn1 protein; cell type; chemoattractant cytokine; chemokine; cyclin-dependent kinase Inhibitor p21; cystein protease; cystein proteinase; cysteine endopeptidase; gene product; glucose control; glucose homeostasis; glucose regulation; in vivo; lung injury; macrophage; mda-6 protein; membrane structure; monocyte; oncoprotein p21; p21 cell cycle regulator; p21 cyclin kinase inhibitor; p21(cip1); p21(waf1-cip1); p21-WAF1; para-Tyrosine; pathway; phosphoinositide-3,4,5-triphosphate; platelet 47k protein; platelet protein P47; pleckstrin; programs; protein p21; pulmonary; pulmonary function; receptor; reproductive; response; second messenger; senescent cell-derived inhibitor protein 1; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases",Intracellular pathways of monocyte survival,,67176,LCMI,"Lung Cellular, Molecular, and Immunobiology Study Section",,8,375000,
7817092,R01,HL,7,,02/01/2010,01/31/2011,PA-07-070,7R01HL069024-08,,NHLBI:386250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,PROVIDENCE,UNITED STATES,,02,075710996,US,RI,029034923,RHODE ISLAND HOSPITAL,"SELLKE, FRANK W;",1920981;,7R01HL069024,12/01/2001,01/31/2012,"3,4',5-stilbenetriol; 3,5,4'-trihydroxystilbene; ANG1; ANGPT1; ANGPT2; ATP[{..}]protein-tyrosine O-phosphotransferase; Active Oxygen; Administration, Oral; Affect; Ang-2; Ang2; Angiogenic Factor; Angiopoietin-1; Angiopoietin-2; Angiostatin; Angiostatins; Animal Model; Animal Models and Related Studies; Animals; Animals, Laboratory; Antioxidants; Assay; BEK fibroblast growth factor receptor; BEK protein tyrosine kinase; Bioassay; Biologic Assays; Biological Assay; Blood Pressure, High; Blood Vessels; Blood flow; Body Tissues; COL18A1; Cell Communication and Signaling; Cell Signaling; Chronic; Clinical Trials; Clinical Trials, Unspecified; Coronary; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary heart disease; DNA Synthesis Factor; Data; Development; Diabetes Mellitus; Diet Modification; Disease; Disorder; Drug Administration, Oral; Dysfunction; ECGF; EPH- and ELK-Related Tyrosine Kinase; EPH-and ELK-Related Kinase; EPHA8; Effectiveness; Endogenous Nitrate Vasodilator; Endostatins; Endothelial Cell Growth Factor; Endothelium; Endothelium-Derived Relaxing Factor; EphA8 Protein; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; Event; Exposure to; FGF; FGF-1 receptor tyrosine kinase; FGF-2; FGF-2 receptor; FGF2; FGFR-1; FGFR-2; FGFR1; FGFR1 protein; FGFR1 tyrosine kinase; FGFR2; FLR; FLT1; FLT1 RTK; FLT1 Receptor Tyrosine Kinase; Factor, Angiogenesis; Failure (biologic function); Family suidae; Fetal Liver Kinase-1; Fibroblast Growth Factor; Fibroblast Growth Factor 2; Fibroblast Growth Factor Receptor 1; Fibroblast Growth Factor Receptor 2; Fibroblast Growth Factor, Basic; Fibroblast Growth Regulatory Factor; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; Flt-1; Free Radicals; Functional disorder; GFAC; Genes; Goals; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; H2O2; HBGF; HBGF-2; HEK3; Heparin-Binding Growth Factor 2; Heparin-Binding Growth Factor Class II; Histologic; Histologically; Human; Human, General; Hydrogen Peroxide; Hydrogen Peroxide (H2O2); Hydroperoxide; Hypercholesteremia; Hypertension; In Vitro; Intracellular Communication and Signaling; Intracellular Second Messengers; Ischemia; Ischemia-Reperfusion Injury; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; Kringles 1-4 of Plasminogen; Laboratories; Laboratory Animals; Left; Left Ventricular Function; MMPs; MR Imaging; MR Tomography; MRI; Magnetic Resonance Imaging; Magnetic Resonance Imaging Scan; Mammals, Mice; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance; Methods; Mice; Modeling; Modifications, Dietary; Molecular; Mononitrogen Monoxide; Murine; Mus; Myocardial; Myocardial Ischemia; Myocardial perfusion; NMR Imaging; NMR Tomography; Nitric Oxide; Nitric Oxide, Endothelium-Derived; Nitrogen Monoxide; Nitrogen Protoxide; Nitrogen oxide; Nuclear; Nuclear Magnetic Resonance Imaging; Operation; Operative Procedures; Operative Surgical Procedures; Oral Administration; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidizing Agents; Oxygen Radicals; PTK; PTK Receptors; Pathway interactions; Patients; Phenol, 4,4'-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl))-; Physiologic; Physiological; Physiopathology; Pigs; Play; Pro-Oxidants; Probucol; Process; Production; Prostate Epithelial Cell Growth Factor; Prostatropin; Protein Tyrosine Kinase; Protein Tyrosine Kinase EEK; Protein-Tyrosine Kinases, src; Proto-Oncogene Protein flt; RTK; Reactive Oxygen Species; Receptor Protein; Receptor Protein-Tyrosine Kinases; Receptor Tyrosine Kinase,Class V; Redox; Regulation; Reperfusion Damage; Reperfusion Injury; Reperfusion Therapy; Research; Resveratrol; Risk Factors; Role; Second Messenger Systems; Second Messengers; Secondary to; Series; Signal Transduction; Signal Transduction Systems; Signaling; Study Section; Suidae; Surgical; Surgical Interventions; Surgical Procedure; Swine; Testing; Therapeutic; Tissues; Transmembrane Receptor Protein Tyrosine Kinase; Tyrosine Kinase; Tyrosine Kinase Growth Factor Receptor; Tyrosine Kinase Linked Receptors; Tyrosine Kinase Receptors; Tyrosine Protein Kinase FRT; Tyrosine Protein Kinase Receptor FLT; Tyrosine-Protein Kinase Receptor EEK; Tyrosine-Specific Protein Kinase; Tyrosylprotein Kinase; VEGF Receptor Flk-1; VEGF Receptor KDR; VEGF Receptor flt-1 Protein; VEGF Receptor, FLT; VEGFR-1; VEGFR-2; VEGFR1; VEGFR2; VEGFs; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vegf; Ventricular; Ventricular Function, Left; Vitamin E; Work; Zeugmatography; ameroid; angiogenesis; angiogenesis therapy; anti-oxidant; antioxidant therapy; bFGF; base; bek fgf receptor kinase; bek fibroblast growth factor receptor kinase; biological signal transduction; clinical investigation; clinical relevance; clinically relevant; coronary disorder; density; diabetes; disease/disorder; electron acceptor; endothelial cell derived relaxing factor; experiment; experimental research; experimental study; failure; fms-Like Tyrosine Kinase; heart ischemia; hydroxyaryl protein kinase; hypercholesterolemia; hyperpiesia; hyperpiesis; hypertensive disease; improved; in vivo; intraoral drug delivery; model organism; myocardial ischemia/hypoxia; myocardium ischemia; oxidant stress; oxidation reduction reaction; pathophysiology; pathway; porcine; receptor; receptor-1, bek-related fibroblast growth factor; reperfusion; research study; response; second messenger; social role; src Kinases; src Tyrosine Kinases; src-Family Kinases; src-Family Tyrosine Kinases; suid; surgery; syndecan-4; therapeutic angiogenesis; transcription factor; tyrosyl protein kinase; vascular",Surgical Intramyocardial Angiogenesis in a Model of Endothelial Dysfunction,,69024,BTSS,"Bioengineering, Technology and Surgical Sciences Study Section",,8,386250,
7781369,R01,HL,7,,02/01/2010,01/31/2011,,7R01HL069594-08,,NHLBI:309000;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,LA JOLLA,UNITED STATES,BIOLOGY,53,804355790,US,CA,920930934,UNIVERSITY OF CALIFORNIA SAN DIEGO,"YELON, DEBORAH L;",1953753;,7R01HL069594,07/01/2002,01/31/2011,"(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; ATRA; All-trans retinoic acid; Animal Model; Animal Models and Related Studies; Atrial; Auricle of Heart; Birth Defects; Brachydanio rerio; Cardiac; Cardiac Atrium; Cardiac Myocytes; Cardiocyte; Cardiomegaly; Cell Communication and Signaling; Cell Signaling; Cells; Characteristics; Collection; Comprehension; Congenital Abnormality; Congenital Anatomic Abnormality; Congenital Anatomical Abnormality; Congenital Defects; Congenital Deformity; Congenital Malformation; Danio rerio; Data; Development; Embryo; Embryo Development; Embryogenesis; Embryonic; Embryonic Development; Enlarged Heart; Exhibits; Forelimb; Gene Expression; Generations; Genes; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Goals; Heart; Heart Atrium; Heart Enlargement; Heart myocyte; Histologic; Histologically; Intracellular Communication and Signaling; Investigators; Maps; Mediator; Mediator of Activation; Mediator of activation protein; Methods and Techniques; Methods, Other; Modeling; Molecular; Molecular Genetic Abnormality; Mother Cells; Muscle Cells, Cardiac; Muscle Cells, Heart; Mutation; Myelogenous; Myeloid; Myocytes, Cardiac; Organ; Organogenesis; Pathway interactions; Pattern; Population; Production; Progenitor Cells; Programs (PT); Programs [Publication Type]; Regulation; Relative; Relative (related person); Research; Research Personnel; Researchers; Resolution; Retinoic Acid; Role; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Staging; Stem cells; Techniques; Testing; Therapeutic; Trans Vitamin A Acid; Tretinoin; Tretinoinum; Ventricular; Vitamin A Acid; Zebra Danio; Zebra Fish; Zebrafish; all-trans-Retinoic Acid; all-trans-Vitamin A acid; atrium; biological signal transduction; cardiogenesis; cardiomyocyte; experiment; experimental research; experimental study; gain of function; gastrulation; genome mutation; heart development; improved; insight; model organism; pathway; progenitor; programs; research study; social role; trans-Retinoic Acid",Genetic Regulation of Cardiac Patterning in Zebrafish,,69594,CDD,Cardiovascular Differentiation and Development Study Section,,8,309000,
7755853,R01,HL,7,,01/15/2010,12/31/2010,PA-07-070,7R01HL074190-06,,NHLBI:413750;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW HAVEN,UNITED STATES,NONE,03,043207562,US,CT,065208047,YALE UNIVERSITY,"HWA, JOHN ;",6872681;,7R01HL074190,07/01/2003,12/31/2013,"3'5'-cyclic ester of AMP; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; Accounting; Adenosine Cyclic 3',5'-Monophosphate; Adenosine Cyclic Monophosphate; Adenosine Cyclic Monophosphate-Dependent Protein Kinases; Adenosine, cyclic 3',5'-(hydrogen phosphate); Affect; African American; Afro American; Afroamerican; Arachidonic Acids; Atheroscleroses; Atherosclerosis; Atherosclerotic Cardiovascular Disease; Banking, Tissue; Binding; Binding (Molecular Function); Bio-Informatics; Biochemical; Bioinformatics; Biology; Black Populations; Black or African American; Blood Vessels; Budgets; COX; COX-1; COX-1 protein; COX-2 protein; COX1; COX2; COX2 enzyme; COX2 inhibitor; COX3; Cahill May Roberts brand of rofecoxib; Cancer, Oncology; Cardiology; Cardiovascular; Cardiovascular Body System; Cardiovascular Disease (Specialty); Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cellular biology; Clinical; Clinical Data; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Collaborations; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Coronary Disease; Coronary heart disease; Coxibs; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclo-Oxygenase-1; Cyclo-Oxygenase-2; Cyclooxygenase; Cyclooxygenase 2 Inhibitors; Cyclooxygenase 3; DNA Alteration; DNA Molecular Biology; DNA mutation; Defect; Development; Disease; Disorder; Dysfunction; Early identification; Endothelium, Vascular; Ensure; Epoprostenol; Epoprostenol Receptors; Ethics; Ethics Committees, Research; Event; Exhibits; Fatty Acid Cyclooxygenase; Feedback; Frequencies (time pattern); Frequency; Functional disorder; Gene Alteration; Gene Mutation; Genetic; Genetic Alteration; Genetic Change; Genetic Polymorphism; Genetic defect; Genetic mutation; Genome, Human; Genomics; Health; Hematology; Heterodimerization; Human; Human Genome; Human, General; Hyperplasia; Hyperplastic; IRBs; In Vitro; Individual; Institutional Review Boards; Intermediary Metabolism; International; Intervention; Intervention Strategies; Intracellular Communication and Signaling; Italy; Knockout Mice; Laboratories; Lead; Leiomyocyte; Ligand Binding; Link; METBL; MSD brand of rofecoxib; Man (Taxonomy); Man, Modern; Maryland; Medical center; Medicine; Merck Frosst brand of rofecoxib; Merck Sharp & Dhome brand of rofecoxib; Merck brand of rofecoxib; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Missense Mutation; Molecular; Molecular Biology; Molecular Interaction; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Mutation; Mutation, Missense; Myocytes, Smooth Muscle; Netherlands; Nomenclature; Null Mouse; Operation; Operative Procedures; Operative Surgical Procedures; Organ System, Cardiovascular; Outcome; PGH Synthase; PGH Synthase 1; PGH Synthase 2; PGHS-1; PGHS-2; PGHS2; PGI2; PGI2 Receptor; PGX; PHS II; PHS1; PKA; PTGIR protein, human; PTGS1; PTGS2; Pathway interactions; Patients; Pb element; Pennsylvania; Pharmacogenetics; Pharmacology; Pharmacology and Toxicology; Phenotype; Physiopathology; Play; Polymorphism (Genetics); Polymorphism, Genetic; Population; Position; Positioning Attribute; Prevention; Production; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Prostacyclin; Prostacyclins; Prostaglandin G/H Synthase 1; Prostaglandin G/H Synthase 2; Prostaglandin G/H Synthase and Cyclooxygenase; Prostaglandin H2 Synthase; Prostaglandin H2 Synthase 1; Prostaglandin H2 Synthase 2; Prostaglandin I(2); Prostaglandin I2; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin-Endoperoxide Synthase 2; Prostaglandins; Prostaglandins I; Prostaglandins X Receptors; Prostanoids; Protein Kinase A; Receptor Protein; Receptor, Prostaglandin I2; Receptors, Epoprostenol; Receptors, Prostacyclin; Recruitment Activity; Research Ethics Committees; Risk; Rofecoxib; Role; Safety; Sampling; Science of Medicine; Screening procedure; Sequence Alteration; Severities; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Smooth Muscle Cells; Smooth Muscle Myocytes; Smooth Muscle Tissue Cell; Structure; Surgical; Surgical Interventions; Surgical Procedure; Testing; Thrombosis; Tissue Banking; Tissue Banks; Tissue Collection; Tissue/Specimen Collection; Universities; Variant; Variation; Vascular Endothelium; Vascular Smooth Muscle Tissue; Vascular, Heart; Vioxx; Vioxx Dolor; Withdrawal; adenosine 3'5' monophosphate; aging population; atherogenesis; atheromatosis; atherosclerotic vascular disease; atherothrombosis; base; biological signal transduction; black American; cAMP; cAMP-Dependent Protein Kinases; cardiovascular disorder; cell biology; circulatory system; clinical investigation; cohort; coronary disorder; cost; cyclo-oxygenase I; cyclo-oxygenase II; cyclooxygenase 1; cyclooxygenase 2; disease/disorder; genetic variant; genome mutation; heavy metal Pb; heavy metal lead; human PTGIR protein; human tissue; inhibitor; inhibitor/antagonist; insight; interest; interventional strategy; mutant; novel; oncology; paracrine; pathophysiology; pathway; polymorphism; prevent; preventing; prostacyclin receptor, human; prostaglandin H synthase-1; prostaglandin H synthase-2; prostaglandin I2 (prostacyclin) receptor protein, human; prostaglandin X; prostanoid IP receptor, human; public health relevance; receptor; receptor function; recruit; restenosis; screening; screenings; social role; surgery; vascular",Pharmacogenetics of the human prostacyclin receptor.," 7. PROJECT NARRATIVE Cardiovascular disease remains the single greatest cause of morbidity and mortality in the USA. With the recent sequencing of the human genome we are now poised to uncover many of the predisposing genetic contributors to cardiovascular disease. We have strong evidence that the prostacyclin receptor and its signaling pathways will play a critical role in the prevention of atherosclerosis, and as such, dysfunctional genetic variants will predispose patients to accelerated disease.",74190,MIST,Molecular and Integrative Signal Transduction Study Section,,6,413750,
7810730,R01,HL,7,,02/01/2010,01/31/2011,,7R01HL074259-08,,NHLBI:366250;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,BIRMINGHAM,UNITED STATES,INTERNAL MEDICINE/MEDICINE,07,063690705,US,AL,35294,UNIVERSITY OF ALABAMA AT BIRMINGHAM,"YOUNG, MARTIN ELLIOT;",6680928;,7R01HL074259,07/01/2003,01/31/2013,"Address; Aging; Animal Model; Animal Models and Related Studies; Arrhythmia; Attenuated; Autoregulation; Blood Pressure; Carbohydrates; Cardiac Arrhythmia; Cardiac Myocytes; Cardiac Output; Cardiac infarction; Cardiocyte; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cardiovascular system (all sites); Cell Communication and Signaling; Cell Signaling; Cell-Extracellular Matrix; Cells; Chronic; Chronotropism, Cardiac; Chronotropisms, Cardiac; Circadian Rhythms; Coupling; D-Glucose; Death, Sudden, Cardiac; Development; Dextrose; Diabetes Mellitus; Diurnal Rhythm; Dysfunction; ECM; Environment; Event; Exhibits; Extracellular Matrix; Fats; Fatty Acids; Fatty acid glycerol esters; Foundations; Functional disorder; Gene Expression; Glucose; Glycolysis; HTRPY; Heart; Heart Arrhythmias; Heart Rate; Heart myocyte; Homeostasis; Hour; Human; Human, General; Hypertrophy; Impairment; In Vitro; Individual; Intermediary Metabolism; Intracellular Communication and Signaling; Investigators; Ions; Ischemia; Ischemic Heart; Ischemic Heart Disease; Ischemic myocardium; Life; Link; METBL; Mammals, Mice; Man (Taxonomy); Man, Modern; Mediating; Metabolic; Metabolic Processes; Metabolism; Metabolism, Lipids/Lipoproteins/Membrane Constituents; Mice; Molecular; Murine; Mus; Muscle Cells, Cardiac; Muscle Cells, Heart; Myocardial; Myocardial Infarct; Myocardial Infarction; Myocardial Ischemia; Myocardial depression; Myocardial dysfunction; Myocytes, Cardiac; Nyctohemeral Rhythm; Organ; Organ System, Cardiovascular; Organism; Pathogenesis; Pathway interactions; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Play; Pressure; Pressure- physical agent; Process; Programs (PT); Programs [Publication Type]; Publishing; Pyruvate; Pyruvates; Reperfusion Therapy; Research Personnel; Researchers; Role; Senescence; Signal Transduction; Signal Transduction Systems; Signaling; Simulate; Stimulus; Testing; Time; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Triacylglycerol; Triglycerides; Twenty-Four Hour Rhythm; Vascular, Heart; Work; base; biological signal transduction; cardiac infarct; cardiomyocyte; cardiovascular disorder; cardiovascular function; circadian; circadian clock; circadian pacemaker; circadian process; circulatory system; coronary attack; coronary infarct; coronary infarction; daily biorhythm; day shift; diabetes; diabetic; diurnal variation; fat metabolism; feeding; glucose transport; glycogenesis; glycogenolysis; heart attack; heart infarct; heart infarction; heart ischemia; heart output; in vivo Model; insight; lipid metabolism; living system; model organism; mouse model; mutant mouse model; myocardial ischemia/hypoxia; myocardium ischemia; night shift; night work; novel; oxidation; pathophysiology; pathway; pressure; programs; reperfusion; response; senescent; shift work; social role",Role of the Molecular Circadian Clock within the Heart,,74259,MIM,Myocardial Ischemia and Metabolism Study Section,,8,366250,
7765499,R01,HL,7,,03/01/2010,02/28/2011,PA-07-070,7R01HL089934-03,,NHLBI:422500;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PATHOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"HLA, TIMOTHY TUN;",1880593;,7R01HL089934,03/07/2008,02/28/2013,"APF-1; ATP-Dependent Proteolysis Factor 1; Address; Adhesion Molecule; Adventitial Cell; Angiogenesis, Pathologic; Angiogenesis, Pathological; Angiogenesis, Physiologic; Angiogenesis, Physiological; Attenuated; Autoregulation; BZS; Biological; Blood Plasma; Blood Vessels; Body Tissues; CSBP1; CSBP2; CSPB1; Cell Adhesion Molecules; Cell Communication and Signaling; Cell Culture System; Cell Junctions; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cell membrane; Cell-Cell Adhesion; Cells; Cellular Migration; Cellular biology; Clinic; Clinical Trials, Phase III; Coupling; Cytoplasmic Membrane; Development; Drug Delivery; Drug Delivery Systems; Drug Targeting; Drug Targetings; Dysfunction; EXIP; Edg Receptors; Endosomes; Endothelial Cells; Endothelium; Endothelium, Vascular; Functional disorder; Gene Copy Number; Gene Dosage; Gene Expression; Generations; Genetic; Goals; Graft Rejection; HMG-20; High Mobility Protein 20; Homeostasis; INFLM; Immune system; In Vitro; Inflammation; Inflammatory; Intercellular Junctions; Intracellular Communication and Signaling; Ligands; Logic; MAPK14; MAPK14 gene; MHAM; MMAC1; MS (Multiple Sclerosis); Mediating; Molecular; Motility; Motility, Cellular; Multiple Sclerosis; Mxi2; Neovascularization, Pathological; Neovascularization, Physiologic; Neovascularization, Physiological; Organelles; PRKM14; PRKM15; PTEN; PTEN gene; PTEN1; Pathologic Neovascularization; Pathology; Pathway interactions; Pericapillary Cell; Pericytes; Perivascular Cell; Phase 3 Clinical Trials; Phase III Clinical Trials; Phenotype; Phosphatase and Tensin Homolog; Phosphatases; Phosphohydrolases; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Physiologic; Physiologic Neovascularization; Physiological; Physiological Homeostasis; Physiopathology; Plasma; Plasma Membrane; Programs (PT); Programs [Publication Type]; Receptor Protein; Receptor Signaling; Receptosomes; Recycling; Regulation; Research; Reticuloendothelial System, Serum, Plasma; Retina; Role; Rouget Cells; S1P Receptor; SAPK2A; Sclerosis, Disseminated; Serum, Plasma; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Sphingosine-1-Phosphate Receptor; Testing; Therapeutic; Tissues; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transplant Rejection; Transplantation Rejection; Tumor Angiogenesis; Tumor Suppressor Proteins; Ubiquitin; Vascular Endothelial Cell; Vascular Endothelium; Vascular Permeabilities; Vascular System; Work; angiogenesis; base; biological signal transduction; body system, allergic/immunologic; cell adhesion protein; cell biology; cell motility; genome, mouse; in vivo; insight; insular sclerosis; lipid mediator; mouse genome; mouse model; mutant; novel; organ system, allergic/immunologic; p38; p38 MAPK Gene; p38Alpha; pathophysiology; pathway; phase 3 study; phase 3 trial; phase III trial; plasmalemma; programs; protocol, phase III; receptor; receptor coupling; response; rho; rho G-Proteins; rho GTP-Binding Proteins; rho GTPases; rho Protein P21; rho Small GTP-Binding Proteins; social role; sphingosine 1-phosphate; study, phase III; tool; tumor suppressor; vascular; vascular bed; vascular inflammation",Sphingosine 1-phosphate receptors in vascular homeostasis and pathology,,89934,VCMB,Vascular Cell and Molecular Biology Study Section,,3,422500,
8000591,R01,MH,7,,01/01/2010,12/31/2010,PA-07-070,7R01MH065304-07,,NIMH:513258;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,ALBUQUERQUE,UNITED STATES,PSYCHIATRY,01,868853094,US,NM,87131,UNIVERSITY OF NEW MEXICO,"CANIVE, JOSE MIGUEL;",2407117;,7R01MH065304,08/05/2002,12/31/2013,"3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Accounting; Address; Affect; Algorithms; Analysis, Data; Animals; Area; Artifacts; Arts; Attention; Auditory; Auditory Cortex; Auditory area; Autoregulation; Bilateral; Biologic Marker; Biological; Biological Markers; Bp50; Brain; CD40; CDW40; COMT; Catechol Methyltransferase; Catechol O-Methyltransferase; Cell Communication and Signaling; Cell Signaling; Characteristics; Clinical; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Compensation; Complex; Data; Data Analyses; Disturbance in cognition; Dopamine; Dysfunction; EC 2.1.1.6; Electrodes; Electroencephalogram; Employee Strikes; Encephalon; Encephalons; Evaluation; Event; Event-Related Potentials; Exhibits; Family member; Financial compensation; First Degree Relative; Functional disorder; Funding; Genetic; Genetic Polymorphism; Genotype; Goals; Heritability; Homeostasis; Hydroxytyramine; Impaired cognition; Individual; Intracellular Communication and Signaling; Investigation; Knowledge; L-valyl-L-valine; Lateral; Left; Lesion; Link; Literature; MGC9013; Magnetism; Magnetoencephalography; Measurement; Measures; Medial; Mediating; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Methods and Techniques; Methods, Other; Methyltransferase Gene; Modeling; Molecular; Molecular Genetic; Molecular Genetics; Molecular Marker; Morphologic artifacts; Nervous; Nervous System, Brain; Neuropsychologic Tests; Neuropsychological Tests; New Territories; Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Noise; Patients; Pattern; Performance; Persons; Phenotype; Physiologic; Physiological; Physiological Homeostasis; Physiopathology; Polymorphism (Genetics); Polymorphism, Genetic; Position; Positioning Attribute; Prefrontal Cortex; Procedures; Process; Proxy; Psychology, Physiologic; Psychology, Physiological; Psychometric; Psychometrics; Psychophysiological; Psychophysiology; Publishing; Receptor Gene; Recruitment Activity; Regulation; Relative; Relative (related person); Reporting; Research; Research Resources; Resolution; Resources; Role; S-Adenosyl-L-methionine[{..}]catechol O-methyltransferase; Sampling; Scalp; Scalp structure; Schizophrenia; Schizophrenic Disorders; Short-Term Memory; Signal Transduction; Signal Transduction Systems; Signaling; Signature Molecule; Site; Source; Stimulus; Strikes; Strikes, Employee; Study of magnetics; Sum; Superior temporal gyrus; TNFRSF5; TNFRSF5 gene; Techniques; Testing; Time; Tumor Necrosis Factor Receptor Superfamily Member 5 Gene; Val-Val; Work; auditory stimulus; base; biological signal transduction; biomarker; clinical significance; clinically significant; cognitive dysfunction; cognitive loss; cognitively impaired; dementia praecox; endophenotype; event related potential; improved; magnetic; meetings; member; neural; neural circuit; neural circuitry; neural mechanism; neuromechanism; neuropsychological; novel; p50; pathophysiology; polymorphism; psycho-physiological; public health relevance; recruit; relating to nervous system; response; schizophrenic; sensory gating; social role; stem; stimulus interval; trait; valylvaline; vector; working memory",Schizophrenia Gating Deficit Mechanisms: Extending the Circuit,,65304,APDA,Adult Psychopathology and Disorders of Aging Study Section,,7,513258,
7766922,R01,MH,7,,02/01/2010,01/31/2011,PA-07-070,7R01MH082830-02,,NIMH:678867;,2010,NATIONAL INSTITUTE OF MENTAL HEALTH,,CHICAGO,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,005436803,US,IL,60611,NORTHWESTERN UNIVERSITY,"WAKSCHLAG, LAUREN S;",1882963;,7R01MH082830,02/10/2009,01/31/2014,"0-11 years old; 1-5 years old; 4-dimensional; 5 year old; AD/HD; ADHD; Active Follow-up; Adolescent; Adolescent Youth; African American; Afro American; Afroamerican; Age; Aggression; Aggressive behavior; Anger; Arts; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Behavior; Behavior Disorder, Disruptive; Behavioral; Black Populations; Black or African American; Calibration; Causality; Characteristics; Child; Child Behavior; Child Youth; Child, Preschool; Childhood; Children (0-21); Classification; Clinic; Clinical; Cognitive Discrimination; Competence; Conduct Disorder; Consensus; Cues; DSM-IV; DSM4; Defiant Disorder, Oppositional; Development; Diagnostic and Statistical Manual of Mental Disorders, 4th edition; Diagnostic and Statistical Manual of Mental Disorders-IV; Dimensions; Discrimination; Discrimination (Psychology); Disruptive Behavior Disorder; Early identification; Effectiveness of Interventions; Ethnic Origin; Ethnicity; Ethnicity aspects; Etiology; FLR; Failure (biologic function); Family; Fear; Foundations; Four-dimensional; Fright; Functional impairment; General Population; General Public; Gibbons; Goals; Heterogeneity; Human, Child; Hylobates; Hylobates Genus; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Impairment; Individual Differences; Intervention; Intervention Strategies; Investigation; Laboratories; Latino; Length of Life; Life; Link; Longevity; Mental disorders; Mental health disorders; Methods; Modeling; Neurocognitive; Nomascus; Non-Hispanic; Not Hispanic or Latino; Nursery Schools; Oppositional Defiant Disorder; Parents; Pattern; Plant Roots; Poverty; Preschool Child; Prevention; Process; Psychiatric Disease; Psychiatric Disorder; Psychopathology; Recruitment Activity; Reporting; Research; Risk Marker; Sampling; Schools, Nursery; Sensitivity and Specificity; Severities; Symphalangus; Symptoms; Systematics; Testing; Time; Unspecified Mental Disorder; Validation; Variant; Variation; abnormal psychology; angers; angry; attention deficit hyperactive disorder; base; behavior disorder diagnosis; black American; boys; children; clinical significance; clinically significant; design; designing; disease causation; disease classification; disease etiology; disease risk; disease/disorder classification; disease/disorder etiology; disorder classification; disorder etiology; disorder risk; disruptive behavioral disorder; early childhood; effect of intervention; failure; five year old; follow-up; functional disability; girls; improved; informant; interventional strategy; juvenile; juvenile human; life span; lifespan; mental illness; non-compliance; nosology; pediatric; preschool child (1-5); psychological disorder; public health relevance; recruit; response; root; sex; theories; youngster",Developmental Characterization of Preschool Disruptive Behavior," Project Narrative While there is growing consensus that disruptive behavior disorders (DBDs) are present in preschool children, there is also increasing recognition that the current DBD nosology is misspecified for early childhood. Establishing a developmentally-sensitive approach to characterizing preschool disruptive behavior will improve early identification and provide a foundation for studies that identify distinct causal processes and targeted prevention efforts.",82830,PDRP,"Psychosocial Development, Risk and Prevention Study Section",,2,678867,
7767661,R01,NS,7,,02/01/2010,01/31/2011,PA-07-070,7R01NS047175-07,,NINDS:326188;,2010,NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE,,COLUMBUS,UNITED STATES,MICROBIOLOGY/IMMUN/VIROLOGY,15,832127323,US,OH,43210,OHIO STATE UNIVERSITY,"POPOVICH, PHILLIP G;",1877671;,7R01NS047175,09/30/2003,01/31/2014,"ATGN; Active Biological Transport; Active Transport; Animals; Antibodies; Antibody Formation; Antibody Production; Antibody Response; Antigen Targeting; Antigens; Area; Arts; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmune Process; Axon; B blood cells; B-Cell Activation; B-Cells; B-Lymphocytes; BCMA; Behavioral; Binding; Binding (Molecular Function); Biologic Transport, Active; Biological; Biological Transport, Active; Blood Circulation; Blood Serum; Blood leukocyte; Bloodstream; Body Tissues; Bruise; Bursa-Dependent Lymphocytes; Bursa-Equivalent Lymphocyte; Cell Communication and Signaling; Cell Signaling; Cell Survival; Cell Viability; Cells; Cerebrospinal Fluid; Chimera Protein; Chimeric Proteins; Chronic; Circulation; Clinical; Closure by Ligation; Complement; Complement Proteins; Contusions; DIF; Data; Demyelinations; Diffusion; Family; Fc Receptor; FcR; Figs; Figs - dietary; Fusion Protein; GFAC; Gamma Globulin, 19S; Gamma Globulin, 7S; Glia; Glial Cells; Grant; Gray; Gray unit of radiation dose; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Hortega cell; Human; Human, General; IgG; IgM; Immune; Immunoglobulin G; Immunoglobulin M; Inflammatory; Infusion; Infusion procedures; Injection of therapeutic agent; Injections; Injury; Intracellular Communication and Signaling; Intrathecal Space; Kolliker's reticulum; Lesion; Leukocytes; Ligands; Ligation; Lymphocyte Function; Mammals, Mice; Man (Taxonomy); Man, Modern; Marrow leukocyte; Mediating; Medulla Spinalis; Methods and Techniques; Methods, Other; Mice; Microglia; Modeling; Molecular Interaction; Murine; Mus; Myelopathy, Traumatic; Nerve Cells; Nerve Unit; Nervous; Nervous System Diseases; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic; Neurologic Disorders; Neurological; Neurological Disorders; Neurons; Non-neuronal cell; Outcome Measure; Palsy; Paralysed; Pathology; Pattern; Peripheral; Plegia; Proteins; Proteomics; Receptor Protein; Recovery; Recovery of Function; Reticuloendothelial System, Leukocytes; Role; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Site; Source; Specificity; Spinal; Spinal Cord; Spinal Cord Trauma; Spinal Trauma; Spinal cord injured; Spinal cord injuries; Spinal cord injury; Structure; T-Cells; T-Lymphocyte; TNF; TNF A; TNF gene; TNFSF2; Techniques; Testing; Therapeutic; Thymus-Dependent Lymphocytes; Time; Tissues; Toxic effect; Toxicities; Tumor Necrosis Factor Gene; Uphill Transport; White Blood Cells; White Cell; Wild Type Mouse; antibody biosynthesis; antibody receptor; antigen antibody binding; autoimmune antibody; autoimmune disorder; biological signal transduction; bis(3-bis(4-chlorophenyl)methyl-4-dimethylaminophenyl)amine; clinical relevance; clinically relevant; experiment; experimental research; experimental study; functional recovery; gene product; gitter cell; immunogen; immunoglobulin biosynthesis; improved; macrophage; mesoglia; microglial cell; microgliocyte; nerve cement; nervous system disorder; neural; neurological disease; neuron toxicity; neuronal; neuronal toxicity; neuropathology; neurotoxic; neurotoxicity; new therapeutic target; novel; paralysis; paralytic; perivascular glial cell; public health relevance; receptor; relating to nervous system; research study; response; self reactive antibody; social role; spatiotemporal; spinal fluid; stem; substantia alba; thymus derived lymphocyte; white blood cell; white blood corpuscle; white matter",Lymphocyte Functions in the Injured Spinal Cord," This proposal will determine the identities of proteins that activate B cells, causing them to produce pathogenic autoantibodies after spinal cord injury (SCI). Moreover, the mechanisms responsible for autoantibody-mediated injury in the spinal cord will be determined and new strategies to block SCI-mediated B cell activation will be developed. Data from these studies will be used to develop novel clinical therapies to treat SCI in humans.",47175,CNNT,Clinical Neuroplasticity and Neurotransmitters Study Section,,7,326188,
7770878,R03,CA,7,,03/01/2010,02/28/2011,PAR-06-458,7R03CA139857-02,,NCI:75000;,2010,NATIONAL CANCER INSTITUTE,,CHICAGO,UNITED STATES,PUBLIC HEALTH & PREV MEDICINE,07,068610245,US,IL,60612,RUSH UNIVERSITY MEDICAL CENTER,"APPELHANS, BRADLEY M.;",9555896;,7R03CA139857,03/01/2009,02/28/2011,"21+ years old; Accounting; Address; Adherence; Adherence (attribute); Adult; Affect; Behavioral; Behavioral Assay; Behavioral Sciences; Body Weight decreased; Caloric Intake; Cancers; Causality; Cessation of life; Counseling; Coupled; Death; Development; Diet; Diet Modification; Dietary Intervention; Eating; Eating Behavior; Energy Expenditure; Energy Intake; Energy Metabolism; Etiology; Fats; Fatty acid glycerol esters; Feeding behaviors; Food; Food Intake; Goals; Guidelines; Gustation; Human; Human, Adult; Human, General; Hunger; Individual; Individual Differences; Ingestive Behavior; Intake; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Measures; Metabolic; Methods; Minority; Modeling; Models, Theoretic; Modifications, Dietary; Mortality; Mortality Vital Statistics; Neurosciences; Nutrition Interventions; Nutritional; Nutritional Interventions; Obesity; Obesity associated cancer; Obesity related cancer; Over weight; Overweight; Participant; Patient Self-Report; Pattern; Play; Population; Prevalence; Prevention; Principal Investigator; Process; Property; Property, LOINC Axis 2; Publishing; Recommendation; Records; Research; Rewards; Risk; Role; Sampling; Science of Statistics; Self-Report; Series; Smoking; Statistics; Taste; Taste Perception; Testing; Theoretical model; Weight; Weight Loss; Weight Reduction; Woman; abstracting; adiposity; adult human (21+); body weight loss; caloric dietary content; cancer prevention; computerized; corpulence; corpulency; corpulentia; discount; discounting; disease causation; disease etiology; disease/disorder etiology; disorder etiology; feeding-related behaviors; food consumption; fruits and vegetables; innovate; innovation; innovative; malignancy; neoplasm/cancer; neurobehavioral; new approaches; novel approaches; novel strategies; novel strategy; nutrient intake activity; obese; obese people; obese person; obese population; pleasure; prevent; preventing; psychologic; psychological; response; saturated fat; social role; statistics; weight loss intervention; wt-loss",Neurobehavioral predictors of diet adherence, Project Narrative  This project aims to determine whether adherence to a weight loss diet is influenced by psychological responses to the immediately rewarding properties of food. Study findings would suggest new approaches for reducing the prevalence of obesity and obesity-related cancers in the US population.,139857,ZCA1,Special Emphasis Panel,,2,75000,
7751909,R03,DC,7,,01/01/2010,12/31/2010,PAR-07-287,7R03DC008403-03,,NIDCD:146025;,2010,NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS,,CHARLESTON,UNITED STATES,OTHER HEALTH PROFESSIONS,01,183710748,US,SC,29425,MEDICAL UNIVERSITY OF SOUTH CAROLINA,"BONILHA, HEATHER SHAW;",8455752;,7R03DC008403,01/01/2008,12/31/2010,"Abscission; Accounting; Address; Animal Welfare; Anterior; Area; Automation; Behavior; Bibliography; Biomechanics; Body Tissues; Bolus; Bolus Infusion; Characteristics; Clinical; Coughing; Country; D-Glucose; Data; Deglutition; Dextrose; Diffuse; Dropsy; Ecological impact; Edema; Environment; Environmental Impact; Equipment; Esthesia; Ethics Committees, Research; Excision; Extirpation; Future; Glucose; Goals; Head and Neck, Larynx; Head and Neck, Pharynx; Hydration; Hydration status; Hydrops; Hygiene; IACUC; IRBs; Impact, Environmental; Institutional Animal Care and Use Committee; Institutional Review Boards; Instrumentation, Other; International; Judgment; Knowledge; Laryngeal; Laryngeal Diseases; Laryngeal Disorder; Larynx; Larynx Diseases; Liquid substance; Literature; Location; Logistic Regressions; Logistics; Logit Models; Measurement; Measures; Mechanics; Medial; Methods; Methods and Techniques; Methods, Other; Modeling; Models, Logit; Movement; Mucous body substance; Mucus; National Institute on Deafness and Other Communication Disorders; Nature; Outcome; Participant; Patients; Pattern; Persons; Pharyngeal structure; Pharynx; Pharynxs; Phonation; Physiologic; Physiological; Pilot Projects; Principal Investigator; Procedures; Production; Programs (PT); Programs [Publication Type]; Proteins; Publishing; Regressions, Logistic; Removal; Reporting; Research; Research Design; Research Ethics Committees; Research Resources; Resources; Risk; Sampling; Science of Statistics; Screening procedure; Sensation; Specific Gravity; Speed; Speed (motion); Statistics; Stroboscopy; Study Subject; Study Type; Surgical Removal; Swallowing; Swelling; Symptoms; Techniques; Testing; Thick; Thickness; Throat; Time; Tissues; Treatment Efficacy; True Vocal Cord; United States; Urinary System, Urine; Urine; Vertebrate Animals; Vertebrates; Vibration; Vibration - physical agent; Visual; Vocal Cords; Vocal Fold; Vocal cord structure; Voice; Voice Disorders; Voice Quality; abstracting; base; body movement; clinical significance; clinically significant; expiration; fluid; gene product; human subject; in vivo; instrumentation; kinematics; larynx disorder; liquid; mucous; novel; pilot study; programs; resection; screening; screenings; statistics; study design; therapeutic efficacy; therapeutically effective; trend; vertebrata; vibration; vocal cord; voice box","Throat Clearing, Coughing, and Alternative Behaviors",,8403,ZDC1,Special Emphasis Panel,,3,146025,
7807913,R37,HL,7,,12/01/2009,11/30/2010,,7R37HL067330-10,,NHLBI:410248;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,NEW YORK,UNITED STATES,PATHOLOGY,14,060217502,US,NY,10065,WEILL MEDICAL COLLEGE OF CORNELL UNIV,"HLA, TIMOTHY TUN;",1880593;,7R37HL067330,03/05/2001,11/30/2010,"4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))-; 4-Sphingenine; Adenomatous Polyps; Affect; Autoregulation; Blood; Blood Plasma; Blood Vessels; Body Tissues; Cell Communication and Signaling; Cell Cycle; Cell Division Cycle; Cell Growth in Number; Cell Multiplication; Cell Proliferation; Cell Signaling; Cells; Cellular Proliferation; Chimera Protein; Chimeric Proteins; Clinical Trials, Phase III; Data; Drugs; Dysfunction; EC 2.7; Enzymes; Functional disorder; Fusion Protein; G Protein-Complex Receptor; G-Protein-Coupled Receptors; Generalized Growth; Genes; Grant; Growth; Hematopoietic; Homeostasis; Immune; Immunomodulators; Immunosuppressants; Immunosuppressive Agents; Intermediary Metabolism; Intestinal Neoplasia; Intestinal Neoplasms; Intestinal Tumor; Intestines Neoplasms; Intracellular Communication and Signaling; Isoenzymes; Isoforms; Isozymes; Kinases; Knockout Mice; Life; Location; Logic; METBL; Mediator; Mediator of Activation; Mediator of activation protein; Medication; Metabolic Processes; Metabolism; Mice, Knock-out; Mice, Knockout; Modeling; Molecular; Null Mouse; Pharmaceutic Preparations; Pharmaceutical Preparations; Phase 3 Clinical Trials; Phase III Clinical Trials; Phosphorylation; Phosphotransferases; Physiological Homeostasis; Physiopathology; Plasma; Protein Isoforms; Protein Phosphorylation; Receptor Activation; Receptor Protein; Reticuloendothelial System, Blood; Reticuloendothelial System, Serum, Plasma; SPHK1 enzyme; Serum, Plasma; Signal Transduction; Signal Transduction Systems; Signaling; Source; Sphingolipids; Sphingosine; System; System, LOINC Axis 4; Testing; Tissue Growth; Tissues; Transphosphorylases; Tumor Cell; Tumor Tissue; Tumor of the Intestines; Vascular Permeabilities; analog; angiogenesis; base; biological signal transduction; drug/agent; extracellular; immunosuppressive; inhibitor; inhibitor/antagonist; interstitial; intestine growth; lipid mediator; mouse model; neoplastic cell; ontogeny; pathophysiology; phase 3 study; phase 3 trial; phase III trial; polypoid adenoma; protocol, phase III; receptor; response; sphingosine 1-phosphate; sphingosine kinase; sphingosine kinase-1; study, phase III; trafficking; vascular",Sphingolipid modulators of vascular growth & homeostasis,,67330,VCMB,Vascular Cell and Molecular Biology Study Section,,10,410248,
7782606,R01,AG,9,,02/01/2010,01/31/2011,PA-07-070,9R01AG037193-06,,NIA:452083;,2010,NATIONAL INSTITUTE ON AGING,,BOSTON,UNITED STATES,,08,005492160,US,MA,02118,BOSTON MEDICAL CENTER,"BHASIN, SHALENDAR ;",8093710;,9R01AG037193,09/30/2004,01/31/2015,"(17Beta)-17-hydroxyandrost-4-en-3-one; 17-beta-Hydroxy-4-Androsten-3-one; 17beta-Hydroxy-5alpha-Androstan-3-One; 21+ years old; 5 alpha-Dihydrotestosterone; 5-alpha-DHT; Activin-Binding Protein; Adult; Affect; Age; Amino Acids; Androgen Receptor; Androgenic Agents; Androgenic Compounds; Androgens; Androst-4-en-17beta-ol-3-one; Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-; Androstanolone; Body Composition; Bone-Derived Transforming Growth Factor; COAD; COPD; CTNNB1; CUL-2; Cadherin-Associated Protein, Beta; Cadherin-Associated Protein, Beta 1 (88kD); Cancer of Prostate; Catenin, Beta-1; Cell Communication and Signaling; Cell Differentiation; Cell Differentiation process; Cell Nucleus; Cell Signaling; Cells; Chronic Disease; Chronic Illness; Chronic Obstructive Airway Disease; Chronic Obstructive Lung Disease; Clinical Trials; Clinical Trials, Unspecified; Communication; DHT; Data; Delta4-androsten-17beta-ol-3-one; Development; Dihydrotestosterone; Dose; ESRD; End stage renal failure; End-Stage Kidney Disease; Epithelial Cells; Family member; Fats; Fatty acid glycerol esters; Follistatin; Funding; Gene Targeting; Generalized Growth; Genetic; Genital System, Male, Prostate; Grant; Growth; HIV Infections; HTLV-III Infections; HTLV-III-LAV Infections; Health; Human Prostate; Human Prostate Gland; Human, Adult; In Vitro; Individual; Intracellular Communication and Signaling; Investigation; Label; Ligands; Link; MADH7; MADH7 gene; MADH8; Malignant Cell; Malignant Tumor of the Prostate; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammals, Mice; Mediating; Mediator; Mediator of Activation; Mediator of activation protein; Mesenchymal; Mesenchymal Differentiation; Mesenchymal Progenitor Cell; Mesenchymal Stem Cells; Mice; Milk Growth Factor; Molecular; Mother Cells; Multipotent Stem Cells; Murine; Mus; Muscle; Muscle Proteins; Muscle Tissue; Muscle, Skeletal; Muscle, Voluntary; Nucleus; PRO2286; Pathway interactions; Peptide Biosynthesis, Ribosomal; Performance; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phosphorylation; Physical Function; Platelet Transforming Growth Factor; Play; Principal Investigator; Progenitor Cells; Programs (PT); Programs [Publication Type]; Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Protein Biosynthesis; Protein Biosynthesis, Ribosomal; Protein Degradation, Metabolic; Protein Degradation, Regulatory; Protein Phosphorylation; Protein Synthesis, Ribosomal; Protein Turnover; Pulmonary Disease, Chronic Obstructive; Receptor Signaling; Regulation; Renal Disease, End-Stage; Role; SMAD7; Sales; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skeletal Muscle Tissue; Skeletal muscle structure; Societies; Stanolone; Stem cells; Stream; Supplementation; System; System, LOINC Axis 4; T-Lymphotropic Virus Type III Infections, Human; TCF-4; TCF4; TCF7L2; TCF7L2 gene; TGF B; TGF-beta; TGFbeta; Targetings, Gene; Testing; Testosterone; Therapeutic Androgen; Therapeutic Androstanolone; Therapeutic Testosterone; Tissue Growth; Trans-Testosterone; Transforming Growth Factor beta; Up-Regulation; Up-Regulation (Physiology); Upregulation; Visceral; adipogenesis; adult human (21+); aminoacid; beta catenin; biological signal transduction; cancer cell; chronic disease/disorder; chronic disorder; clinical investigation; deprivation; hormonal regulation; hormone regulation; improved; in vivo; interest; lipid biosynthesis; lipogenesis; men; men's; multipotent cell; multipotent progenitor; muscle form; muscle strength; myogenesis; myostatin; novel; older men; ontogeny; pathway; programs; protein degradation; protein synthesis; public health relevance; selective androgen receptor modulator; social role; socioeconomic; socioeconomically; socioeconomics; stem cell differentiation; translational study",Mechanisms of Testosterone Action," Program Director/Principal Investigator: Bhasin, Shalender Narrative Aging-associated limitations of physical function impose an enormous health and socioeconomic burden on the individual and the society; therefore, there is substantial unmet need for the development of function promoting anabolic therapies. The proposed translational studies will elucidate the signaling mechanisms by which testosterone increases skeletal muscle mass and provide novel leads for the discovery of more selective anabolic molecules, such as follistatin, that might increase skeletal muscle mass and function without affecting the prostate. The proposed project also provides an outstanding opportunity to further our understanding of hormonal regulation of stem cell differentiation and cell fate.",37193,ASG,Aging Systems and Geriatrics Study Section,,6,452083,
8014329,N01,AI,,,,,,N01AI15441-12-0-1,,NIAID:30870;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,,,,,932325574,,,,,"HELMS, RONALD W.;",8624049;,N01AI15441-12-0-1,05/01/2001,12/31/2008,,Bacteriology and Mycology Biostatistical and Operations Unit (BAMBU),,0,,,,,30870,
8014328,N01,AI,,,,,,N01AI30047-12-0-1,,NIAID:967812;,2010,NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES,,BIRMINGHAM,UNITED STATES,,06,006900526,US,AL,35205,SOUTHERN RESEARCH INSTITUTE,"MURRAY, MICHAEL ;",10485096;,N01AI30047-12-0-1,09/30/2003,09/29/2010,,In Vitro Antiviral Screening Program,,0,,,,,967812,
8014393,N01,HL,,,,,,N01HV48196-8-0-1,,NHLBI:287702;,2010,"NATIONAL HEART, LUNG, AND BLOOD INSTITUTE",,ROCKVILLE,UNITED STATES,,08,076364392,US,MD,20850,"J. CRAIG VENTER INSTITUTE, INC.","KIRKNESS, EWEN ;",10484880;,N01HV48196-8-0-1,09/30/2004,09/29/2010,,NHLBI DNA Re-sequencing and Genotyping Program,,0,,,,,287702,